Miracle-dz/UniFAR-FTUs huggingface dataset:
Update on the Pathology and Diagnosis of Interstitial Cystitis/Bladder Pain Syndrome: A Review

Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by bladder discomfort, urinary frequency, urgency, and pelvic pain. The etiology and pathogenesis of this condition is still unknown and remains diagnosed by exclusion. The histologic findings are also neither specific for diagnosis nor correlated with symptoms. However, the definition and diagnostic criteria for the condition was established in the last decade. In this paper, we review the changes in the definition, terminology, and diagnostic scheme of IC/BPS, and summarize the histologic findings. We also briefly discuss some new pathologic suggestions and new urinary markers, focusing on the most promising ones.
Are Prisons Any Better?: Twenty Years of Correctional Reform

The Prison - Clemens Bartollas Disorder Personified Legal Mandates and Changes in Prisons - Dennis L Peck and John O Smykla Changes in Prison Facilities as a Function of Correctional Philosophy - Randall I Atlas and Roger G Dunham Developments in Prison Administration - David England Philosophical Issues Related to Prison Reform - Algis Mickunas The Idea of Community Correctional Reform - Dan A Lewis and Cheryl Darling How Rhetoric and Reality Join The Privatization of Prisons - T Don Hutto Behavioral and Psychological Considerations in the Success of Prison Reform - Edward Zamble Treatment Modalities Within Prison - T Paul Louis and Jerry R Sparger Conclusion - John W Murphy and Jack E Dison
Perspectives of Young Emerging Adults With Serious Mental Health Conditions on Vocational Peer Mentors

For early emerging adults with serious mental health conditions, vocational services with peer mentors are a promising adaptation of adult system evidence-based practices. Peer mentors were added to the Individual Placement and Support model of supported employment for 17- to 20-year-olds receiving residential and psychiatric care. To explore the feasibility of vocational peer mentors, open-ended satisfaction surveys and the Working Alliance Inventory were administered to mentees at 12 months. Thematic analysis of surveys reveals the importance of peer mentor authenticity, flexibility, and being a graduate of the mental health program where vocational services were based. Valued relational processes include the act of talking in the community, feeling understood, and forming a bond with peer mentors. Mentees with positive peer mentoring experiences reported stronger working alliances. This study sheds light onto near-age mentoring relational processes for this population, which can inform future research of mentoring processes and intervention design.
A Review and Evaluation of Meta-Analysis Practices in Management Research

Meta-analysis has become increasingly popular in management research to quantitatively integrate research findings across a large number of studies. In an effort to help shape future applications of meta-analysis in management, this study chronicles and evaluates the decisions that management researchers made in 69 meta-analytic studies published between 1980 and 2007 in 14 management journals. It performs four meta-analyses of relationships that have been studied with varying frequency in management research, to provide empirical evidence that meta-analytical decisions influence results. The implications of the findings are discussed with a focus on the changes that seem appropriate.
Limit theorems for theta sums

For almost all values of x 2 R, the classical theta sum S N (x) = N ? 1=2 N X n=1 e 2i n 2 x exhibits an extremely irregular behaviour, as N tends to innnity. This limit is investigated by exploiting a connection to the ergodic properties of ows on the unit tangent bundle of a surface of constant negative curvature.
Research self‐efficacy, publication output, and early career development

Purpose – This paper has two aims: to investigate the relationship of self‐efficacy beliefs in terms of research on publication output; and, to identify the relationship of self‐efficacy beliefs about research to the publishing outputs of neophyte lecturers.Design/methodology/approach – A questionnaire was utilised to obtain responses from lecturers working full‐time at two large Australian universities (n=343). The data from this sample were analysed using factor analysis, correlation, and multiple regression analysis. Data from two sub‐samples of neophyte lecturer (n1=47; n2=78) were then subjected to a multivariate analysis of variance.Findings – Four research self‐efficacy subscales were derived from a factor analysis. These subscales were positively and significantly related and accounted for 46 percent of the total variance in total publications accrued. Significant differences were found between two groups of neophyte lecturer on nearly all items forming the respective research self‐efficacy subsca.
Turnover Intentions and Voluntary Turnover: The Moderating Role of Network Centrality

The intention to leave a job has been shown to be the best predictor of turnover, but rarely explains more than 20% of this behavior. This article explores how centrality in social networks moderates the relationship between turnover intentions and turnover behavior, and provides insight into why some employees translate turnover intentions into turnover behavior, while others do not. Results indicate that higher levels of centrality in friendship and advice networks weaken the intentions-turnover relationship, while lower levels of centrality strengthen this linkage. These findings extend the theory of planned behavior by showing that attachment and obligation may prevent the translation of intentions into behavior. This paper also contributes to the turnover literature by re-positioning social network centrality in the decision process. Practical implications are also discussed.
CYP1A2 Activity as Measured by a Caffeine Test Predicts Clozapine and Active Metabolite Norclozapine Steady-State Concentration in Patients With Schizophrenia

Clozapine is an atypical antipsychotic drug and displays efficacy in 30% to 60% of patients with schizophrenia who do not respond to traditional antipsychotics. A clozapine concentration greater than 1,150 nmol/L increases the probability of antipsychotic efficacy. However, plasma clozapine concentration can vary more than 45-fold during long-term treatment. The aim of this study was to assess the contribution of CYP1A2 to variability in steady-state concentration of clozapine and its active metabolite norclozapine. Patients with schizo-phrenia or schizoaffective disorder were prospectively monitored during clozapine treatment (N = 18). The in vivo CYP1A2 activity was measured using the caffeine metabolic ratio (CMR) in overnight urine. Trough plasma samples were drawn after at least 5 days of treatment with a constant regimen of clozapine. A significant negative association was found between the CMR and the dose-corrected clozapine (r s = −0.87, p < 0.01) and norclozapine (r s = −0.76, p < 0.01) concentrations. Nonsmokers displayed a higher clozapine (3.2-fold) and norclozapine (2.3-fold) concentration than smokers (p < 0.05). Furthermore, there was marked person-to-person variation in CYP1A2 activity during multiple-dose clozapine treatment (coefficient of variation = 60%). Age, weight, serum creatinine, and grapefruit juice consumption did not significantly contribute to variability in clozapine and norclozapine concentration (p > 0.05). In conclusion, CYP1A2 is one of the important contributors to disposition of clozapine during multiple-dose treatment. Although further in vitro experiments are necessary, the precise metabolic pathways catalyzed by CYP1A2 seem to be subsequent to the formation of norclozapine, hitherto less recognized quantitatively important alternate disposition routes, or both. From a clinical perspective, an environmentally induced or constitutively high CYP1A2 expression can lead to a decrease in steady-state concentration of clozapine as well as its active metabolite norclozapine. Thus, interindividual variability in CYP1A2 activity may potentially explain treatment resistance to clozapine in some patients. CYP1A2 phenotyping with a simple caffeine test may contribute to individualization of clozapine dosage and differentiate between treat ment noncompliance and high CYP1A2 activity.
Glucagon as a target for the treatment of Type 2 diabetes

Glucagon is the key counter-regulatory hormone that opposes the action of insulin. In states of relative hypoglycaemia, glucagon acts to increase blood glucose by stimulating hepatic glycogen breakdown and gluconeogenesis to achieve euglycaemia. Type 2 diabetes is characterised by inappropriate regulation of hepatic glucose production, which is due, at least in part, to an imbalance in the bihormonal relationship between plasma levels of glucagon and insulin. The glucose-lowering effects of glucagon peptide antagonists and antiglucagon neutralising antibodies first demonstrated the potential of glucagon receptor (GCGR) antagonism as a treatment for hyperglycaemia. In recent years, the development of GCGR antisense oligonucleotides and small molecular weight GCGR antagonists have been pursued as possible therapeu-tic agents to target glucagon action as a treatment for Type 2 diabe-tes.
A Generic Individual-Based Spatially Explicit Model as a Novel Tool for Investigating Insect-Plant Interactions: A Case Study of the Behavioural Ecology of Frugivorous Tephritidae

Computational modelling of mechanisms underlying processes in the real world can be of great value in understanding complex biological behaviours. Uptake in general biology and ecology has been rapid. However, it often requires specific data sets that are overly costly in time and resources to collect. The aim of the current study was to test whether a generic behavioural ecology model constructed using published data could give realistic outputs for individual species. An individual-based model was developed using the Pattern-Oriented Modelling (POM) strategy and protocol, based on behavioural rules associated with insect movement choices. Frugivorous Tephritidae (fruit flies) were chosen because of economic significance in global agriculture and the multiple published data sets available for a range of species. The Queensland fruit fly (Qfly), Bactrocera tryoni, was identified as a suitable individual species for testing. Plant canopies with modified architecture were used to run predictive simulations. A field study was then conducted to validate our model predictions on how plant architecture affects fruit flies’ behaviours. Characteristics of plant architecture such as different shapes, e.g., closed-canopy and vase-shaped, affected fly movement patterns and time spent on host fruit. The number of visits to host fruit also differed between the edge and centre in closed-canopy plants. Compared to plant architecture, host fruit has less contribution to effects on flies’ movement patterns. The results from this model, combined with our field study and published empirical data suggest that placing fly traps in the upper canopy at the edge should work best. Such a modelling approach allows rapid testing of ideas about organismal interactions with environmental substrates in silico rather than in vivo, to generate new perspectives. Using published data provides a saving in time and resources. Adjustments for specific questions can be achieved by refinement of parameters based on targeted experiments.
“I’d Say it’s Kind of Unique in a Way”

This article tracks the emergence, maintenance, and evolution of a positive intercultural relationship between a multilingual international student from Vietnam and a monolingual local Australian student in their first year at university. The literature overwhelmingly suggests that in institutions where English is the language of instruction, monolingual local students rarely mix with international students who are not fully proficient in English. This dyad thus provided fertile ground for exploring the development of an unusual intercultural student relationship. Narrative analysis explores the extent to which individual agency and the institutional environment coshaped this relationship over time and in various contexts. In the context of the internationalization of the tertiary education sphere, this study offers a prototypical case highlighting affordances and constraints that may influence the development of productive and amicable intercultural relationships on diverse university campuses.
Use of Oral Contraceptives Blunts the Calciuric Effect of Caffeine in Young Adult Women 1

Caffeine consumption increases the urinary excretion of calcium and other minerals. Factors that affect caffeine metabolism such as steroid hormones may modify this effect. The purpose of this study was to evaluate the inﬂuence of oral contraceptive (OC) use on the 4-h urinary excretion of calcium, phosphorus, magnesium, zinc, sodium, potassium and caffeine metabolites in response to a high caffeine dose given as coffee beverage. Adult women, 20–29 y, users ( (cid:1) OC, n (cid:2) 15) and nonusers ( (cid:3) OC, n (cid:2) 15) of oral contraceptives, with calcium intake (cid:4) 500 mg/d, participated in two tests, caffeine load (5 mg/kg body weight) and no-caffeine control, in a randomized crossover design. The net increase (caffeine load corrected by no caffeine) in urinary excretion of most minerals was signiﬁcantly higher in (cid:3) OC than in (cid:1) OC ( P (cid:5) 0.05), with the larger group difference for calcium (ninefold) followed by magnesium (twofold), zinc (onefold) and potassium (onefold). Net increases in urinary excretion of 1-methylurate and paraxanthine were about three- and ﬁvefold higher, respectively, in (cid:3) OC than in (cid:1) OC ( P (cid:5) 0.05) whereas net increases in urinary excretion of 5-acetylamino-6-formylamino-3-methyluracil (AFMU) and 1,7-dimethylurate were over twofold higher in the (cid:1) OC than in (cid:3) OC ( P (cid:5) 0.05). Following the caffeine load, most urinary minerals showed negative correlation with urinary 1-methylurate in (cid:3) OC (R (cid:1) (cid:3) 0.78, P (cid:5) 0.01), and with urinary AFMU and 1,7-dimethylurate in (cid:1) OC (R (cid:1) (cid:3) 0.84, P (cid:5) 0.01). Oral contraceptives appear to limit the renal effect of caffeine on mineral excretion possibly by reducing paraxanthine excretion, the most active caffeine metabolite. J. Nutr. 133: 393–398, 2003. was used to examine the responses to the caffeine load, with each woman being her own control, and the Mann– Whitney test was used to evaluate the differences by OC use in net increases. The relationship between urinary mineral excretions and caffeine metabolites was examined using the Pearson correlation matrix (minerals vs. minerals), and the Spearman correlation matrix (minerals vs. caffeine metabolites). Values of P (cid:5) 0.05 were considered signiﬁcant. The statistical analysis was performed using Stat- graphics Version 7 for DOS (Manugistics, Cambridge, MA).
Epidemiology of Encapsulating Peritoneal Sclerosis in Japan

Since the first peritoneal dialysis (PD) patients with encapsulating peritoneal sclerosis (EPS) were reported in 1980, EPS has been considered primarily a fatal complication. The incidence of EPS in PD patients has been reported to range from 0.7% to 7.3%, and the rate appears to be higher in patients receiving long-term treatment. The most recent data from Japan show an overall incidence of 2.5%, with a clear impact of extended PD duration, which also augments mortality. The incidence increases and the prognosis worsens with longer durations of PD. The incidences (and mortality rates) for EPS were 0% (0%), 0.7% (0%), 2.1% (8.3%), 5.9% (28.6%), 5.8% (61.5%), and 17.2% (100%) for patients who had undergone PD for 3, 5, 8, 10, 15, and >15 years respectively. Because EPS occurs after withdrawal from PD in more than half of patients with the condition, strict monitoring is necessary when a long-term patient is withdrawn from PD. Maintaining patients on standard PD for more than 8 years using conventional solutions is associated with a substantial risk for the development of EPS.
Marion Island volcanism and glaciation

Abstract Sub-Antarctic Marion Island was the site of extensive volcanism as well as glaciation during both the Quaternary and the Holocene. Initial reconstructions suggested a link between deglaciation and the initiation of faulting which, in turn, facilitated lava eruptions during the interglacials. However, our reassessment of the faulting, volcanic rock, and palaeoglacier distribution indicate that these original interpretations were erroneous. Features thought to be due to faulting are shown to be erosional scarps and this significantly changes interpretations of former glacier distribution. Further, the loss of the former ice cap has revealed new information on former glaciers and their flow directions, thereby allowing reconstruction of palaeoglaciers. Our new reconstruction fits with information from invertebrate genetic mapping that suggest some lava outcrops were nunataks and, therefore, refuges during the Last Glacial period. The new findings of glacial landforms in areas previously covered by snow suggest there was a significant ice advance during the Little Ice Age. Although Holocene volcanic rocks overlie and mask much of the glacial evidence, it has been possible to develop a proposed new reconstruction for glaciation, which is presented together with some of the implications.
Measuring organizational learning from errors: Development and validation of an integrated model and questionnaire

Errors are an inevitable by-product of human labour. Therefore, organizational learning from errors should be regarded as a strategic goal of HR development. Despite a large number of studies on organizational learning from errors, a thorough understanding of error-related learning processes at work is still missing. In the present article, we present the results of a literature review that was used to derive an integrated model of organizational learning processes in the consequence of errors and to develop the questionnaire to assess the error-related learning climate in organizations. The questionnaire was evaluated on a sample of 383 employees of two companies. Confirmatory factor analyses support the suggested structure of error-related learning climate. Further analyses stress the relevance of constructive error handling in organizations by revealing substantial links between error-related learning climate and the effectiveness of error learning, self-perceptions and error-related behaviours of team members, as well as group cohesion and certain aspects of team performance.
Computational Analysis of Candidate Disease Genes and Variants for Salt-Sensitive Hypertension in Indigenous Southern Africans

Multiple factors underlie susceptibility to essential hypertension, including a significant genetic and ethnic component, and environmental effects. Blood pressure response of hypertensive individuals to salt is heterogeneous, but salt sensitivity appears more prevalent in people of indigenous African origin. The underlying genetics of salt-sensitive hypertension, however, are poorly understood. In this study, computational methods including text- and data-mining have been used to select and prioritize candidate aetiological genes for salt-sensitive hypertension. Additionally, we have compared allele frequencies and copy number variation for single nucleotide polymorphisms in candidate genes between indigenous Southern African and Caucasian populations, with the aim of identifying candidate genes with significant variability between the population groups: identifying genetic variability between population groups can exploit ethnic differences in disease prevalence to aid with prioritisation of good candidate genes. Our top-ranking candidate genes include parathyroid hormone precursor (PTH) and type-1angiotensin II receptor (AGTR1). We propose that the candidate genes identified in this study warrant further investigation as potential aetiological genes for salt-sensitive hypertension.
Challenges of Capturing Natural Web-Based User Behaviors

It can be difficult to properly understand aspects of user behavior on the Web without examining the behaviors in a realistic setting, such as through field studies. In this article, an overview of the experiences in augmenting logged data with contextual information over the course of two separate research projects conducted in the field is presented. One project investigated the privacy sensitivity of normal Web browsing, and the other examined user behavior during Web-based information-seeking tasks. Throughout both projects, the contextual information was collected through participant annotations of their Web usage. Based on experiences in conducting this research, implications of methodological decisions are considered, unanswered questions are highlighted, and considerations for other researchers are provided. These shared experiences and perspectives will assist future researchers planning similar field studies, allowing them to build upon the lessons learned.
Relationship Between Sonographic Characteristics and Afirma Gene Expression Classifier Results in Thyroid Nodules With Indeterminate Fine-Needle Aspiration Cytopathology.

OBJECTIVE The purpose of this article is to investigate whether specific clinical and sonographic characteristics are predictive of a benign Afirma test result. MATERIALS AND METHODS We conducted a retrospective study of Afirma gene expression classifier analysis performed in 44 patients with 45 indeterminate thyroid fine-needle aspiration (FNA) cytologic results between March 2013 and April 2014. Of these, 33 of 45 nodules (73.3%) were repeat atypia of undetermined significance (AUS) and follicular lesions of undetermined significance (FLUS), or follicular neoplasm (FN) and suspicious for a follicular neoplasm (SFN) before Afirma testing. RESULTS Of the 45 nodules, 21 (46.7%) were cytologically diagnosed as FLUS, 16 (35.6%) were diagnosed as AUS, and eight (17.8%) were diagnosed as FN or SFN. By Afirma testing, 23 of the 45 nodules (51.1%) were benign, 21 (46.7%) were suspicious, and one (2.2%) had nondiagnostic results. The mean (± SD) nodule size was smaller in the Afirma-benign group than in the Afirma-suspicious group (1.8 ± 0.8 cm [95% CI, 1.4-2.1] vs 2.2 ± 0.8 cm [95% CI, 1.8-2.6]; p < 0.035). No sonographic feature was statistically significantly different between the Afirma-benign and -suspicious groups, including nodule solidity (p = 0.225), echogenicity (p = 0.543), calcification (p = 0.542), and hypervascularity (p = 0.976). All nodules were ovoid shaped and had circumscribed margins in both Afirma groups. CONCLUSION Smaller nodule size was the only characteristic associated with a benign diagnosis on Afirma testing. Sonographic characteristics are not helpful in cases that had a repeat indeterminate FNA finding before Afirma testing.
How Online Social Networks Affect my Job Choice Intention: an Empirical Approach

Recent years have witnessed the rapid proliferation of social networking sites, which have gradually changed people’s way to deal with employment and recruitment process. From job seekers’ perspective, their occupational decisions will be consciously or unconsciously affected by information and activities in online social networks. In this study, we focus on job choice intention, which is formed from an impressionable and suggestible state, but has predictive power on the final decision. Since it is a fairly new angle with scant literature, we adopted an exploratory approach and identified two influence mechanisms built upon expectancy theory. We conducted a survey on graduating college students from IT-related majors, and examined how the online social networks serve as information providers and interactive platforms. Our results suggest that online social networks have significant impact on job choice intentions through information seeking behaviors and peer influence.