Miracle-dz/UniFAR-FTUs huggingface dataset:
Mitral valve leaflet remodelling during pregnancy: insights into cell-mediated recovery of tissue homeostasis

Little is known about how valvular tissues grow and remodel in response to altered loading. In this work, we used the pregnancy state to represent a non-pathological cardiac volume overload that distends the mitral valve (MV), using both extant and new experimental data and a modified form of our MV structural constitutive model. We determined that there was an initial period of permanent set-like deformation where no remodelling occurs, followed by a remodelling phase that resulted in near-complete restoration of homeostatic tissue-level behaviour. In addition, we observed that changes in the underlying MV interstitial cell (MVIC) geometry closely paralleled the tissue-level remodelling events, undergoing an initial passive perturbation followed by a gradual recovery to the pre-pregnant state. Collectively, these results suggest that valvular remodelling is actively mediated by average MVIC deformations (i.e. not cycle to cycle, but over a period of weeks). Moreover, tissue-level remodelling is likely to be accomplished by serial and parallel additions of fibrillar material to restore the mean homeostatic fibre stress and MVIC geometries. This finding has significant implications in efforts to understand and predict MV growth and remodelling following such events as myocardial infarction and surgical repair, which also place the valve under altered loading conditions.
Retinal ganglion cells in Alzheimer's disease and aging

Optic nerve and retinal gangliion cell (GC) degeneration are possible explanations for the poor visul function reported in patients with Alzheimer's disease (AD). We investigated whether GC loss could be attributed to AD compared with control subjects by measuring the spatial density of GC(vells/mm2) with methods previously used to analyze the GC distribution of young normal retinas. Retinas from 4 autopsy‐confirmed, severely demented partients with AD and 4 age and sex‐matched control subjects (ages, 66‐86 yr for both groups) withould history of dementing or ocular disease were prepared as unstained whold mounts. Therer was no evidence for loss of GC within the central 43 degrees of vision in patients with AD. The densityof GC subserving the central 11 degrees of vision was reduced by one‐fourth in both AD and control eyes compared with retinas from young adults, as was GC density in a wedge of nasal retina. This loss may contribute to deficits in visual function found in aged individuals, whether or not they have dementia.
Non-tuberculous mycobacteria in patients with bronchiectasis

Background: Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms. Patients with pre-existing lung damage are susceptible to NTM, but their prevalence in bronchiectasis is unknown. Distinguishing between lung colonisation and disease can be difficult. Methods: A prospective study of 100 patients with bronchiectasis was undertaken to evaluate the prevalence of NTM in sputum, and a retrospective analysis of clinical, microbiological, lung function and radiology data of our clinic patients with NTM sputum isolates over 11 years was performed. Results: The prevalence of NTM in this population of patients with bronchiectasis was 2%. Patients in the retrospective study were divided into three groups: bronchiectasis + multiple NTM isolates (n = 25), bronchiectasis + single isolates (n = 23), and non-bronchiectasis + multiple isolates (n = 22). Mycobacterium avium complex (MAC) species predominated in patients with bronchiectasis compared with non-bronchiectasis lung disease (72% v 9%, p<0.0001). Single isolates were also frequently MAC (45.5%). Multiple isolates in bronchiectasis were more often smear positive on first sample than single isolates (p<0.0001). NTM were identified on routine screening samples or because of suggestive radiology. No particular bronchiectasis aetiology was associated with an NTM. Pseudomonas aeruginosa and Staphylococcus aureus were frequently co-cultured. Six (25%) of multiple NTM patients had cavities of which five were due to MAC. Half the patients with multiple isolates were treated, mostly due to progressive radiology. Conclusions: NTM are uncommon in non-cystic fibrosis bronchiectasis. Routine screening identifies otherwise unsuspected patients. MAC is the most frequent NTM isolated.
The measurement of alexithymia in children and adolescents: Psychometric properties of the Alexithymia Questionnaire for Children and the twenty-item Toronto Alexithymia Scale in different non-clinical and clinical samples of children and adolescents

This study had two aims. Firstly, the psychometric properties of the 20-item Toronto Alexithymia Scale (TAS-20) and the Alexithymia Questionnaire for Children (AQC) that measure the three dimensions of alexithymia (DIF, difficulty identifying feelings; DDF, difficulty describing feelings; EOT, externally-oriented thinking) were explored in various samples of children, adolescents or young adults to detect the best factor-structure and to examine if the Externally-Oriented Thinking (EOT) factor must be deleted or not. Secondly, the capacity for adolescents to distinguish between alexithymia and depression was studied using factorial analyses of items of self-report of alexithymia and depression scales. Four groups were examined (80 healthy children, 105 adolescents with various psychiatric disorders, 333 healthy older adolescents and 505 young adults recruited from universities). The first two groups filled out the AQC and the latter two the TAS-20. Confirmatory factorial analyses (CFA) showed that the two-factor model (DIF, DDF) provided acceptable fits and had significant advantages over the three-factor model (DIF, DDF, EOT). Low alpha coefficients for the EOT subscale were reported (range from 0.18–0.61). Except for the children sample, exploratory factorial analyses (EFA) were performed on the items of the TAS-20 or AQC without the EOT items and the Beck depression inventory-II (BDI-II) or the Zung Self-Rating Depression Scale (SDS). The items of the AQC and BDI-II or items of the TAS-20 and SDS loaded on separate factors with only a minor overlap suggesting that adolescents were able to differentiate alexithymia and depression when self-assessments were used. Alexithymia can be reliably assessed in adolescents using the TAS-20 or AQC without the eight items rating the EOT dimension.
Ventricular Dilation and Electrical Dyssynchrony Synergistically Increase Regional Mechanical Nonuniformity But Not Mechanical Dyssynchrony: A Computational Model

Background—Heart failure (HF) in combination with mechanical dyssynchrony is associated with a high mortality rate. To quantify contractile dysfunction in patients with HF, investigators have proposed several indices of mechanical dyssynchrony, including percentile range of time to peak shortening (WTpeak), circumferential uniformity ratio estimate (CURE), and internal stretch fraction (ISF). The goal of this study was to compare the sensitivity of these indices to 4 major abnormalities responsible for cardiac dysfunction in dyssynchronous HF: dilation, negative inotropy, negative lusitropy, and dyssynchronous activation. Methods and Results—All combinations of these 4 major abnormalities were included in 3D computational models of ventricular electromechanics. Compared with a nonfailing heart model, ventricles were dilated, inotropy was reduced, twitch duration was prolonged, and activation sequence was changed from normal to left bundle branch block. In the nonfailing heart, CURE, ISF, and WTpeak were 0.97±0.004, 0.010±0.002, and 78±1 milliseconds, respectively. With dilation alone, CURE decreased 2.0±0.07%, ISF increased 58±47%, and WTpeak increased 31±3%. With dyssynchronous activation alone, CURE decreased 15±0.6%, ISF increased 14-fold (±3), and WTpeak increased 121±4%. With the combination of dilation and dyssynchronous activation, CURE decreased 23±0.8%, ISF increased 20-fold (±5), and WTpeak increased 147±5%. Conclusions—Dilation and left bundle branch block combined synergistically decreased regional cardiac function. CURE and ISF were sensitive to this combination, but WTpeak was not. CURE and ISF also reflected the relative nonuniform distribution of regional work better than WTpeak. These findings might explain why CURE and ISF are better predictors of reverse remodeling in cardiac resynchronization therapy.
Prevention of Colorectal Cancer by Targeting Obesity-Related Disorders and Inflammation

Colorectal cancer is a major healthcare concern worldwide. Many experimental and clinical studies have been conducted to date to discover agents that help in the prevention of this disease. Chronic inflammation in colonic mucosa and obesity, and its related metabolic abnormalities, are considered to increase the risk of colorectal cancer. Therefore, treatments targeting these factors might be a promising strategy to prevent the development of colorectal cancer. Among a number of functional foods, various phytochemicals, including tea catechins, which have anti-inflammatory and anti-obesity properties, and medicinal agents that ameliorate metabolic disorders, might also be beneficial in the prevention of colorectal cancer. In this review article, we summarize the strategies for preventing colorectal cancer by targeting obesity-related disorders and inflammation through nutraceutical and pharmaceutical approaches, and discuss the mechanisms of several phytochemicals and medicinal drugs used in basic and clinical research, especially focusing on the effects of green tea catechins.
Emotional Gestalts: Appraisal, Change, and the Dynamics of Affect

This article interprets emotional change as a transition in a complex dynamical system. We argue that the appropriate kind of dynamical system is one that extends recent work on how neural networks can perform parallel constraint satisfaction. Parallel processes that integrate both cognitive and affective constraints can give rise to states that we call emotional gestalts, and transitions can be understood as emotional gestalt shifts. We describe computational models that simulate such phenomena in ways that show how dynamical and gestalt metaphors can be given a concrete realization.
Epidemiological Trends of Sexually Transmitted Infections Among Women in Cheonan, South Korea, 2011–2017

Sexually transmitted infections (STIs) spread through sexual contact and have a profound impact on sexual and reproductive health worldwide [1]. Accurate diagnosis of STIs is critical because they can cause serious complications such as miscarriage, premature birth, and pelvic infections in pregnant women [1−3]. The causative pathogens of STIs include bacteria, viruses, protozoa, and fungi. The major causative pathogens are Ureaplasma urealyticum (UU), Mycoplasma hominis (MH), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Mycoplasma genitalium (MG), and Trichomonas vaginalis (TV) [3]. UU and MH are frequently found in the commensal flora of the lower genital tract [4−6]. Until the 1970s, UU was considered a non-pathogenic bacterium normally present in the genitourinary tract [5]. However, recent studies have linked UU and MH with maternal complications such as miscarriage, pelvic inflammation, and premature labor in pregnant women. Infection with these organisms during pregnancy can also cause respiratory disease and sepsis in newborns [5, 7]. CT is a major cause of non-gonococcal chlamydial infection [8]. CT infection in the genital tract can cause pelvic inflammation, extra uterine pregnancy, chronic pelvic pain, and epididymitis [8, 9]. Furthermore, CT Sexually transmitted infections (STIs) are a global health concern and can cause serious complications such as miscarriage, premature birth, and pelvic infection in pregnant women. Therefore, accurate diagnosis and information on the epidemiologic trends are critical. However, studies of STI trends in Cheonan, South Korea, have not been conducted since 2012. We examined the STI trends in the Cheonan area after 2012. From January 2011 to September 2017, 3,362 cervical swab specimens from female patients were sampled at the Dankook University Hospital and analyzed by multiplex PCR. Of the 3,362 specimens, 1,281 were positive for pathogens (38.92%). A total of 1,893 pathogens were detected. Ureaplasma urealyticum, Mycoplasma hominis, and Chlamydia trachomatis were the most frequent pathogens, accounting for 36.29% (687/1,893), 30.16% (571/1,893), and 19.97% (378/1,893) of the pathogen-positive samples, respectively. In the 2009–2012 analysis, M. hominis was identified as the predominant pathogen in STI samples, whereas U. urealyticum was identified as the major pathogen in this study. In many countries, including South Korea and the United States, the rate of STIs is increasing, while a decreasing trend was observed in Cheonan.
High-frequency isolated ac-dc converter with stacked architecture

This paper presents a new isolated ac-dc power converter achieving both high power factor and converter miniaturization suitable for many low power ac-dc applications. The proposed ac-dc converter architecture comprises a line-frequency rectifier, a stack of capacitors, a set of regulating converters, and a multi-input isolated bus converter. Among many suitable circuit implementations, the prototype system utilizes the resonant-transition buck converter as a regulating converter, and the capacitively-aided isolated bus converter for the isolated bus converter. The converter is miniaturized by operating at high frequency (1–10 MHz range), and it buffers the ac-line frequency energy with a pair of stacked ceramic capacitors (1 μΕ and 150 μΕ, 100 V rating) without a requirement for electrolytic capacitors. The prototype converter is implemented to operate from 120 Vac to 12 V, and up to 50 W output as an example isolated ac-dc converter for power supply applications. The prototype converter demonstrates with 88 % efficiency and 0.86 power factor, and provides 50 W/in3 power density, which is five times higher than the power density of typical conventional designs.
The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein

The E2 proteins are transcription/replication factors from papillomaviruses. Human papillomaviruses (HPVs) can be broadly divided in two groups; low-risk HPV subtypes cause benign warts while high-risk HPVs give rise to cervical cancer. Although a range of crystal structures of E2 DNA-binding domains (DBD) from both high- and low-risk HPV subtypes have been reported previously, structures of E2 DBD:DNA complexes have only been available for high-risk HPV18 and bovine papillomavirus (BPV1). In the present study we report the unliganded and DNA complex structures of the E2 DBD from the low-risk HPV6. As in the previous E2–DNA structures, complex formation results in considerable bending of the DNA, which is facilitated by sequences with A:T-rich spacers that adopt a pre-bent conformation. The low-risk HPV6 E2–DNA complex differs from the earlier structures in that minimal deformation of the protein accompanies complex formation. Stopped-flow kinetic studies confirm that both high- and low-risk E2 proteins adapt their structures on binding to DNA, although this is achieved more readily for HPV6 E2. It therefore appears that the higher selectivity of the HPV6 E2 protein may arise from its limited molecular adaptability, a property that might distinguish the behaviour of E2 proteins from high- and low-risk HPV subtypes.
A Multi-objective Gravitational Search Algorithm

Recently there has been a great research conducted on diverse variations of multi-objective swarm optimization algorithms each of which might have its own strengths and weaknesses. Due to the high complexity of multi-objective problems the efficiency of these methods has become a matter of concern. In this paper a new multi-objective meta-heuristic algorithm based on gravitational forces is proposed and applied to different test benches. The acquired results proved the superiority of the algorithm comparing with other pioneering techniques such as the MOPSO
Optimized FaeG Expression and a Thermolabile Enterotoxin DNA Adjuvant Enhance Priming of an Intestinal Immune Response by an FaeG DNA Vaccine in Pigs

ABSTRACT One of the problems hindering the development of DNA vaccines is the relatively low immunogenicity often seen in humans and large animals compared to that in mice. In the present study, we tried to enhance the immunogenicity of a pcDNA1/faeG19 DNA vaccine in pigs by optimizing the FaeG expression plasmid and by coadministration of the plasmid vectors encoding the A and B subunits of the Escherichia coli thermolabile enterotoxin (LT). The insertion of a Kozak sequence and optimization of vector (cellular localization and expression) and both vector and codon usage were all shown to enhance in vitro FaeG expression compared to that of pcDNA1/faeG19. Subsequently, pcDNA1/faeG19 and the vector-optimized and the vector-codon-optimized construct were tested for their immunogenicity in pigs. In line with the in vitro results, antibody responses were better induced with increasing expression. The LT vectors additionally enhanced the antibody response, although not significantly, and were necessary to induce an F4-specific cellular response. These vectors were also added because LT has been described to direct the systemic response towards a mucosal immunoglobulin A (IgA) response in mice. Here, however, the intradermal FaeG DNA prime-oral F4 boost immunization resulted in a mainly systemic IgG response, with only a marginal but significant reduction in F4+E. coli fecal excretion when the piglets were primed with pWRGFaeGopt and pWRGFaeGopt with the LT vectors.
Seed Yield and Nutrient Content of Mungbean and Soil Nutrient Status as Influenced by Application of Micronutrients Mixture in a Alfisol

India is recognised as the principal producer, consumer, processor and importer of pulses in the world. Paradoxically, the country pulse production has reached at 19.5 million tonnes from the acreage of 24.5 million hectares. Expectedly, as the countries domestic requirements would be around 26.50 mt by 2030, it necessitates stepping up of production by almost 7.0 mt of additional produce. Pulses are rich source of protein and they maintain soil fertility through biological nitrogen fixation in soil and thus play a vital role in sustainability. The reasons for decreasing productivity are due to decreasing soil fertility especially macro and micronutrients, imbalanced use of fertilizer and occurrences of physiological disorders factors such as inefficient partitioning of assimilates, poor pod setting, excessive flower abscission and lack of nutrients during the critical stages of crop growth leading to nutrient stress, poor growth and productivity were found to be some of the yield barriers of pulse crop. International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 7 Number 09 (2018) Journal homepage: http://www.ijcmas. com
Fixed Point Quantization of Deep Convolutional Networks

In recent years increasingly complex architectures for deep convolution networks (DCNs) have been proposed to boost the performance on image recognition tasks. However, the gains in performance have come at a cost of substantial increase in computation and model storage resources. Fixed point implementation of DCNs has the potential to alleviate some of these complexities and facilitate potential deployment on embedded hardware. In this paper, we propose a quantizer design for fixed point implementation of DCNs. We formulate and solve an optimization problem to identify optimal fixed point bit-width allocation across DCN layers. Our experiments show that in comparison to equal bitwidth settings, the fixed point DCNs with optimized bit width allocation offer > 20%reduction in the model size without any loss in accuracy on CIFAR-10 benchmark. We also demonstrate that fine-tuning can further enhance the accuracy of fixed point DCNs beyond that of the original floating point model. In doing so, we report a new state-of-the-art fixed point performance of 6.78% error-rate on CIFAR-10 benchmark.
A Model for Worldwide Tracking of Distributed Objects

We describe a service forlocating distributed objectsidentified by location-independent object identifiers. An object in our model is physically distributed, with multiple active copies on different machines. Processes must bind to an object in order to invoke its methods. Part of the binding protocol is concerned with contacting the object, which offers one or more contact points. An object can change its contact points in the course of time, thus exhibiting migration behavior. We present a solution to finding an object’s contact points which is based on a worldwide distributed search tree that adapts dynamically to individual migration patterns.
Federal Reserve Bank of New York Staff Reports Preferences and Biases in Educational Choices and Labor Market Expectations: Shrinking the Black Box of Gender Preferences and Biases in Educational Choices and Labor Market Expectations: Shrinking the Black Box of Gender

paper presents preliminary findings and is being distributed to economists and other interested readers solely to stimulate discussion and elicit comments. The views expressed in this paper are those of the authors and are not necessarily reflective of views at the Federal Reserve Bank of New York or the Federal Reserve System. Any errors or omissions are the responsibility of the authors. Abstract Standard observed characteristics explain only part of the differences between men and women in education choices and labor market trajectories. Using an experiment to derive students' levels of overconfidence, and preferences for competitiveness and risk, this paper investigates whether these behavioral biases and preferences explain gender differences in college major choices and expected future earnings. In a sample of high-ability undergraduates, we find that competitiveness and overconfidence, but not risk aversion, are systematically related with expectations about future earnings: Individuals who are overconfident and overly competitive have significantly higher earnings expectations. Moreover, gender differences in overconfidence and competitiveness explain about 18 percent of the gender gap in earnings expectations. These experimental measures explain as much of the gender gap in earnings expectations as a rich set of control variables, including test scores and family background, and they are poorly proxied by these same control variables, underscoring that they represent independent variation. While expected earnings are related to college major choices, the experimental measures are not related with college major choice. The authors thank the NYU Center for Experimental Social Sciences (CESS) for providing assistance in conducting the survey and experiment. They thank participants at presentations at the 2012 North American ESA Meetings and the University of Essex. Grant Graziani and Victoria Gregory provided outstanding research assistance. The views expressed in this paper are those of the authors and do not necessarily reflect the position of the Federal Reserve Bank of New York or the Federal Reserve System.