Miracle-dz/UniFAR-FTUs huggingface dataset:
The Resiliency Scales for Children and Adolescents, Psychological Symptoms, and Clinical Status in Adolescents

The Resiliency Scales for Children and Adolescents (RSCA) are three scales for assessing the relative strength of three aspects of personal resiliency as a profile in children and adolescents. This article presents preliminary evidence to support the use of the RSCA in preventive screening. First, this article examines associations between the RSCA Global scale and index scores and psychological symptoms as assessed by the Beck Youth Inventory—II in a normative sample of adolescents. A normative sample was chosen as screening would presumably occur in a nonclinical setting. Findings suggest associations between psychological symptoms and the RSCA scale and index scores. Specifically, positive associations were found between psychological symptoms and the RSCA Vulnerability Index and the Emotional Reactivity scale score. Negative associations were found between psychological symptoms and the RSCA Resource Index, Sense of Mastery, and Sense of Relatedness scale scores. Second, the RSCA is examined as a potential predictor of clinical status differentiating the normative sample from a clinical sample. Results support the use of the RSCA in screening protocols for the identification of vulnerability that does not rely on the presence of an identified disorder or clearly defined psychological symptoms. Les Resiliency Scales for Children and Adolescents (RSCA), constituées de trois échelles, servent à évaluer la force relative de trois aspects de la résilience personnelle en tant que profil chez les enfants et les adolescents. Nous présentons ici des données préliminaires qui soutiennent l'emploi des RSCA lors de dépistages préventifs. Dans un premier temps, nous examinons, dans un échantillon normatif d'adolescents, des associations entre l'échelle globale des RSCA et des symptômes psychologiques établis selon l'Inventaire Beck-II pour adolescents. Notre choix a porté sur un groupe normatif, car le dépistage se ferait probablement dans un cadre non clinique. Les résultats suggèrent des associations entre les symptômes psychologiques et les scores sur l'échelle et les index des RSCA. Plus précisément, on note des associations positives entre les symptômes et l'index de Vulnérabilité et le score de l'échelle de Réactivité émotionnelle des RSCA. Des associations négatives apparaissent entre les symptômes psychologiques et l'index de Ressource, l'échelle du Sens de la maîtrise et celle du Sens de connexion des RSCA. Dans un deuxième temps, nous évaluons les RSCA en tant que prédicteurs potentiels de l'état clinique, pour différencier un échantillon normatif d'un groupe clinique. Les résultats soutiennent l'emploi des RSCA dans les protocoles de dépistage destinés à identifier la vulnérabilité en l'absence d'un trouble identifié ou de symptômes psychologiques clairement définis.
Interactive Metal Fatigue: A Conceptual Contribution to Social Critique in Mobilities Research

Abstract The ‘mobilities turn’ has reinvigorated the social critique on the automobility system. Theorizing its profound reconfigurations of social life, relationist commitments invite a certain silence regarding the associated social pathologies, however. This article explores a critical-theoretical interpretation of the mobilities paradigm. It proposes the ‘interactive metal fatigue’ (IMF) concept, which theorizes the emergence of ‘interpassive’ social relations as socio-technical dialectics. Taking into account the contradictions that surround the critical-theoretical project, IMF paves the way for balanced critiques of mobilities. This will be shown through the case of Shared Space, an attempt to free public space from traffic management colonization.
Writing Up Research: Experimental Research Report Writing for Students of English

Although microcomputers are now common in classrooms throughout the United States, it is not clear what their most effective role is in the teaching-learning process. This study compared the effects of microcomputer-assisted instruction and traditional lecture-discussion on the performance of graduate students enrolled in an agricultural education course. Students in the control group performed significantly better on a written test than either of the two treatment groups. Students having previous experience with computers did not perform significantly better than FIGURE 1.1 Typical sections of the experimental research report. The Experimental Research Report-An Example To help you understand the basic format of the experimental research report, we present here a report originally published in a profeSSional journal. The report describes a study carried out in the field of agricultural education. The study evaluates the effectiveness of using microcomputers to teach economic principles to university students in a graduate course. Sociology Engineering Business Biology Psychology Language Management Chemistry Animal Science Education Economics Agronomy All these kinds of studies share some common characteristics. First, they are :lesigned around a research question. As a possible answer to the research ques·on, the researcher formulates a hypothesis and then designs the study in such a ay as to reject or support the hypothesis. Also, such studies are usually quantiatiue-that is, they deal with numerical data obtained in carrying out the study. hese data are usually treated with one or more statistical tests to determine how eriously the results should be taken. The reports written to describe these different kinds of studies also have uch in common. Normally, a report includes descriptions of the purpose, ethod, and results of the study. Complete results are usually presented in tables nd graphs. Such a report contains references to other published works in the arne area of study. A bibliography (a list of references) listing these works, along ith all the information needed to find them in a library, is always included at the nd of the report. Finally, a brief summary or an abstract covering the most imortant information in the report is usually attached. The organizational format for all experimental research reports is basically the same, regardless of the field of study in which the author is working. Some of the research fields treated in this book are listed here. The following diagram illustrates the major sections of a typical experimental ~esearch report in the order in which they are usually presented. The diagram ~Iso shows the chapters in this book that deal with each of the sections.
Relative Deep Habits

This paper generalizes the standard habit formation model to an environment in which agents form habits over individual varieties of goods as opposed to over a composite consumption good. We refer to this preference specification as ‘deep habit formation. ’ Under deep habits, the demand function faced by individual producers depends on past sales. This feature is typically assumed ad-hoc in customer market and brand switching cost models. A central result of the paper is that deep habits give rise to countercyclical markups, which is in line with the empirical evidence. This result is important because ad-hoc formulations of customer-market and switching-cost models have been criticized for implying procyclical and hence counterfactual markup movements. Under deep habits, consumption and wages respond procyclically to government spending shocks. The paper provides econometric estimates of the parameters pertaining to the deep habit model. JEL Classification: D10, D12, D42, E30.
Correcting for cancer genome size and tumour cell content enables better estimation of copy number alterations from next-generation sequence data

MOTIVATION Comparison of read depths from next-generation sequencing between cancer and normal cells makes the estimation of copy number alteration (CNA) possible, even at very low coverage. However, estimating CNA from patients' tumour samples poses considerable challenges due to infiltration with normal cells and aneuploid cancer genomes. Here we provide a method that corrects contamination with normal cells and adjusts for genomes of different sizes so that the actual copy number of each region can be estimated. RESULTS The procedure consists of several steps. First, we identify the multi-modality of the distribution of smoothed ratios. Then we use the estimates of the mean (modes) to identify underlying ploidy and the contamination level, and finally we perform the correction. The results indicate that the method works properly to estimate genomic regions with gains and losses in a range of simulated data as well as in two datasets from lung cancer patients. It also proves a powerful tool when analysing publicly available data from two cell lines (HCC1143 and COLO829). AVAILABILITY An R package, called CNAnorm, is available at http://www.precancer. leeds.ac. uk/cnanorm or from Bioconductor. CONTACT a.gusnanto@leeds.ac. uk SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Learning from Complexity: Effects of Prior Accidents and Incidents on Airlines' Learning

Using data on accidents and incidents experienced by U.S. commercial airlines from 1983 to 1997, we investigated variation in firm learning by examining whether firms learn more from errors with heterogeneous or homogeneous causes. We measured learning by a reduction in airline accident and incident rates, while controlling for other factors related to accidents and incidents. Our results show that heterogeneity is generally better for learning, as prior heterogeneity in the causes of errors decreases subsequent accident rates, producing a deeper, broader search for causality than simple explanations like “blame the pilot. ” The benefits of heterogeneity, however, apply mainly to specialist airlines. Generalist airlines learn, instead, from outside factors such as the experience of others and general improvements in technology. These results suggest a theory of learning across organizational forms: complex forms benefit from simple information, and simple forms benefit from complex information. The implications of our study for learning theories and work on organizational errors are discussed.
Tt8 Controls Its Own Expression in a Feedback Regulation Involving Ttg1 and Homologous Myb and Bhlh Factors, Allowing a Strong and Cell-specific Accumulation of Flavonoids in Arabidopsis Thaliana

The control of TT8 expression was investigated in this study, and it was demonstrated that it constitutes a major regulatory step in the specific activation of the expression of flavonoid structural genes. First, the GUS activity generated in planta from a TT8::uidA construct revealed cell-specific activation of the TT8 promoter consistent with the known involvement of the TT8 bHLH factor in proanthocyanidin, anthocyanin and mucilage biosynthesis. Moreover, the activity of this reporter construct was strongly affected in ttg1, TT2 overexpressers (OE), and PAP1-OE, suggesting interplay between TT2, PAP1, TTG1 and the activation of the TT8 promoter in planta. To further investigate the mechanisms involved, we used 35S::TT2-GR and 35S::TTG1-GR transgenic plants (expressing fusion proteins with the glucocorticoid receptor), as well as one-hybrid experiments, to determine the direct effect of these factors on TT8 expression. Interestingly, in vivo binding of TT2 and PAP1 to the TT8 promoter was dependent on the simultaneous expression of TT8 or the homologous bHLH factors GL3 and EGL3. Consistent with these results, the activity of the TT8::uidA reporter was strongly affected in the seed endothelium of a tt8 mutant. Similarly, a strong decrease in the level of TT8 mRNA was detected in the siliques of a gl3 · egl3 mutant and in plants that express a dominant negative form of the PAP1 protein, suggesting that TT8 expression is controlled by different combinations of MYB and bHLH factors in planta. The importance of this positive feedback mechanism in the strong and specific induction of proanthocyanidin biosynthesis in the seed coat of Arabidopsis thaliana is discussed.
Functional analysis of the periphery effect in human building related areas

Several studies have shown that a region in the anterior collateral sulcus (CoS) and a region in the vicinity of the transverse occipital sulcus (TOS) are preferentially activated by images of buildings and scenes. We have found recently that these regions show a strong activation bias to stimuli located in the peripheral visual field. We explore in detail the source of this “periphery” effect. Our results show that the periphery effect can be generated by a large single object occupying the peripheral visual field as well as by multiple small peripheral objects. We also investigated whether the periphery effect was related to the annular shape used in conventional mapping of the visual field periphery and found that the mere presence of a stimulus in the visual field periphery, regardless of object shape, is sufficient to enhance activation. We also found that a small bias toward the peripheral visual field was shown even when the stimulated areas in the central and peripheral parts of the visual field are equated. Finally, our results demonstrate that the periphery effect shows object selectivity that can be obtained even with face images, which are the non‐optimal stimulus for this region. In summary, our study shows that the building‐related CoS and TOS manifest a true but graded retinotopic bias toward the peripheral visual field. Hum. Brain Mapp. 22:17–28, 2004. © 2004 Wiley‐Liss, Inc.
A survey on parasite management by equine veterinarians highlights the need for a regulation change

Introduction In-depth knowledge of the use of anthelminthics in the field, especially by veterinarians, is required to design more sustainable parasite control strategies. Materials and methods An online survey was sent by e-mail to 940 equine veterinary practitioners to describe their equine practice, their awareness about parasites and the management strategies they apply. Results Gastrointestinal parasites were generally considered (68%) as an issue of moderate importance. Drug efficacy failure was a minor or moderate issue for 47% and 48% of responders, respectively. Parasite management mostly relied on the use of systematic calendar treatments across a wide variety of horse owners (ie, riding schools, studs or hobby horse owners). Almost half of the practitioners (42%) never performed Faecal Egg Count (FEC) before drenching. Horse owners or their employees in charge of equines were reported to be the only person managing drenching in 59% of the collected answers. This was associated with the report of many off-label uses of anthelmintics and the frequent buying of drugs using the internet. Conclusions Given the critical situation regarding anthelmintic resistance, it seems necessary for veterinarians to reclaim parasite management and prevention as a specific topic. Implementation of stricter regulations for use of anthelmintics, like the one applied in Denmark, may make parasitic management in equids more sustainable.
Two-Point L1 Shortest Path Queries in the Plane

Let P be a set of h pairwise-disjoint polygonal obstacles with a total of n vertices in the plane. In this paper, we consider the problem of building a data structure that can quickly compute an L1 shortest obstacle-avoiding path between any two query points s and t. We build a data structure of size O(n + h2 · log h · 4√log h) in O(n + h2 · log2 h · 4√log h) time that answers each query in O(log n + k) time, where k is the number of edges of the output path. Note that n + h2 · log2 h · 4√log h = O(n+h2+ϵ) for any constant ϵ > 0. We also extend our techniques to the weighted rectilinear version in which the "obstacles" of P are rectilinear regions with "weights" and allow L1 paths to travel through them with weighted costs. Our algorithm answers each query in O(log n + k) time with a data structure of size O(n2 · log n · 4√log n) that is built in O(n2 · log2 n · 4√log n) time.
Dietary chia seed (Salvia hispanica L.) rich in α-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats

The present study investigates the benefits of the dietary intake of chia seed (Salvia hispanica L.) rich in α-linolenic acid and fibre upon dyslipidaemia and insulin resistance (IR), induced by intake of a sucrose-rich (62·5 %) diet (SRD). To achieve these goals two sets of experiments were designed: (i) to study the prevention of onset of dyslipidaemia and IR in Wistar rats fed during 3 weeks with a SRD in which chia seed was the dietary source of fat; (ii) to analyse the effectiveness of chia seed in improving or reversing the metabolic abnormalities described above. Rats were fed a SRD during 3 months; by the end of this period, stable dyslipidaemia and IR were present in the animals. From months 3–5, half the animals continued with the SRD and the other half were fed a SRD in which the source of fat was substituted by chia seed (SRD+chia). The control group received a diet in which sucrose was replaced by maize starch. The results showed that: (i) dietary chia seed prevented the onset of dyslipidaemia and IR in the rats fed the SRD for 3 weeks – glycaemia did not change; (ii) dyslipidaemia and IR in the long-term SRD-fed rats were normalised without changes in insulinaemia when chia seed provided the dietary fat during the last 2 months of the feeding period. Dietary chia seed reduced the visceral adiposity present in the SRD rats. The present study provides new data regarding the beneficial effect of chia seed upon lipid and glucose homeostasis in an experimental model of dislipidaemia and IR.
Domestic Violence and Child Protection: Partnerships and Collaboration

Abstract The interface between the child protection and domestic violence sectors is often problematic, in that the two sectors operate relatively independently, with little integration. However, it is widely recognised that these sectors need to work more closely to enhance both women's and children's safety. This paper explores the processes needed for the child protection and domestic violence sectors to develop collaborative partnerships that lead to the provision of higher-quality responses to both women and children. Drawing on collaboration theory, a number of barriers to the development of successful partnerships are described, and applied to initiatives that seek to develop integrated approaches between child protection and domestic violence services. It is concluded that there is much scope for the two sectors to work closely together, but that the development of integrated responses involving both child protection and domestic violence services will take a significant commitment, level of determination, and stamina from both parties.
Coorientation of PR Practitioners and News Personnel in Education News

w Since the rise of public relations in the 1920s, news reporters and public relations practitioners have been contemplating each other’s roles and trying to define the boundaries of their relationship. In the process, misunderstandings have occurred, and role stereotypes have taken shape. Reporters, for example, customarily dismiss the public relations trade as “flackery,”’ and PR practitioners and the administrators they work for sometimes see news personnel as incompetent bunglers who quote out of context and sensationalize the negative. * These stereotypes tend to make the PR/reporter relationship a n adversarial one. Yet, Gieber and Johnson found that “despite verbalized differences between sources [in this study, PR practitioners] and reporters of perceptions of the other’s role, the two groups find themselves mutually dependent. ”3
Trastuzumab emtansine: a novel antibody-drug conjugate for HER2-positive breast cancer

Introduction: Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate (ADC) that combines intracellular delivery of the potent cytotoxic agent, DM1 (a derivative of maytansine) with the antitumor activity of trastuzumab. While there are several ADCs in Phase III development, T-DM1 is the only one in which the targeting antibody has antitumor properties. T-DM1 is also the only ADC that is directed toward the human EGFR 2 (HER2). Effective therapies are limited in HER2-positive advanced or metastatic breast cancer (MBC), particularly following progression on available HER2-targeted therapies. Areas covered: The mechanisms of action, preclinical efficacy and clinical profile of T-DM1 are reported. The latest preclinical and clinical data for T-DM1 are examined. Expert opinion: T-DM1 has significant antitumor potency in vitro and in vivo, which is maintained in tumors resistant to trastuzumab or lapatinib. In Phase I and II trials, T-DM1 provided objective tumor responses and was well tolerated across various lines of therapy in patients with HER2-positive MBC. In addition, it showed similar efficacy to trastuzumab plus docetaxel in first-line MBC. Ongoing trials (including two Phase III studies) are investigating T-DM1 as single-agent therapy or combined with other chemotherapeutic or biologic agents, and the results should help to define the place of T-DM1 within current treatment algorithms for HER2-positive disease.
Classification of LHC beam loss spikes using Support Vector Machines

The CERN Large Hadron Collider's (LHC) collimation system is the most complex beam cleaning system ever designed. It requires frequent setups to determine the beam centres and beam sizes at the 86 collimator positions. A collimator jaw is aligned to the beam halo when a clear beam loss spike is detected on a Beam Loss Monitor (BLM) downstream of the collimator. This paper presents a technique for identifying such clear loss spikes with the aid of Support Vector Machines. The training data was gathered from setups held during the first three months of the 2011 LHC run, and the model was tested with data from a machine development period.
Dynamometry for the measurement of grip, pinch, and trunk muscles strength in subjects with subacute stroke: reliability and different number of trials

ABSTRACT Background Muscle strength is usually measured in individuals with stroke with Portable dynamometers (gold standard). However, no studies have investigated the reliability, the standard error of measurement (SEM) and the minimal detectable difference (MDD95%) of the dynamometry for the measurement of hand grip, pinch grip and trunk strength in subjects with subacute stroke. Objective 1) To investigate the intra and inter-rater reliability, the SEM and the MDD95% of the portable dynamometers for the measurement of grip, pinch and trunk strength in subjects with subacute stroke, and 2) to verify whether the use of different number of trials (first trial and the average of the first two and three trials) affected the results. Method 32 subjects with subacute stroke (time since stroke onset: 3.6 months, SD=0.66 months) were evaluated. Hand grip, 3 pinch grips (i.e. pulp-to-pulp/palmar/lateral) and 4 trunk muscles (i.e. flexors, extensors, lateral flexors and rotators) strength were bilaterally assessed (except trunk flexors/extensors) with portable dynamometry by two independent examiners over two sessions (1-2 weeks apart). One-way ANOVAs and intraclass correlation coefficients (ICC2,k) were used for analysis (α=0.05). SEM and MDD95% were also calculated. Results For all muscular groups and sources of outcome values, including one trial, after familiarization, similar results were found (0.01≤F≤0.08; 0.92≤p≤0.99) with significant and adequate values of intra-rater (0.64≤ICC≤0.99; 0.23≤95%CI≤0.99) and inter-rater (0.66≤ICC≤0.99; 0.25≤95%CI≤0.99) reliability. SEM and MDD95% were considered low (0.39≤EPM≤2.21 Kg; 0.96≤MMD95%≤6.12 Kg) for all outcome scores. Conclusion Only one trial, following familiarization, demonstrated adequate intra-rater and inter-rater reliability of the portable dynamometers for the measurement of hand grip, pinch grip and trunk strength in subjects with subacute stroke.