Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Radiation on Gene Expression of Rat Liver Chemokines: In Vivo and In Vitro Studies

Abstract Moriconi, F. , Christiansen, H. , Raddatz, D. , Dudas, J., Hermann, R. M. , Rave-Fränk, M. , Sheikh, N. , Saile, B. , Hess, C. F. and Ramadori, G. Effect of Radiation on Gene Expression of Rat Liver Chemokines: In Vivo and In Vitro Studies. Radiat. Res. 169, 162–169 (2008). The aim of the study was to analyze the effect of a single irradiation on chemokine gene expression in the rat liver and in isolated rat hepatocytes. RNA extracted from livers and from hepatocytes within the first 48 h after irradiation was analyzed by real-time PCR and the Northern blot assay. The chemokine concentrations in the serum of irradiated rats were measured quantitatively by ELISA. A significant radiation-induced increase of CINC1, IP10, MCP1, MIP3α, MIP3β, MIG and ITAC gene expression could be detected at the RNA level in the liver. CINC1, MCP1 and IP10 serum levels were significantly increased. In rat hepatocytes in vitro, only MIP3α showed a radiation-induced increase in expression, while CINC1, IP10, MIP3β, MIG, MIP1α, ITAC and SDF1 RNA levels were significantly down-regulated. However, incubation of irradiated hepatocytes in vitro with either TNF-α, IL1β, or IL6 plus TNF-α led to up-regulation of MCP1, IP10 and MCP1 or CINC1 and MIP3β, respectively. Irradiation of the liver induces up-regulation of the genes of the main proinflammatory chemokines, probably through the action of locally synthesized proinflammatory cytokines. The reason for the lack of liver inflammation in this model has still to be clarified.
Women's status within the household as a determinant of maternal health care use in Nigeria.

BACKGROUND Although gender inequality is often cited as a barrier to improving maternal health in sub-saharan Africa, there is lack of empirical data on how women's socio-cultural characteristics may influence use of health services in Nigeria. OBJECTIVE To describe how women's position in the household affects receipt of maternity care services. METHODS Secondary data analysis of 10,052 and 4,590 currently married women aged 15 to 49 years from the 2008 Nigerian DHS who receive skilled antenatal and delivery care at least till pregnancy was done. RESULTS Receipt of skilled delivery care was by 37.9% while, natal care was by 98.4%. Education, residence and wealth index all significantly influenced receipt of maternal health care. Women who were involved in decision making on their own health (aOR=1.97; 95%CI=1.88-2.06) and were employed throughout the year (aOR=1.11; 95%CI=1.01-1.23) were more likely to receive skilled antenatal care, while those who justified physical intimate partner violence were less likely to receive both skilled antenatal care (aOR=0.92; 95%CI=0.85-0.98) and delivery services (aOR 0.54; 95% CI 0.33-0.87). CONCLUSION Interventions aimed at improving maternal care should promote women empowerment (decision making, self worth, educational and economic) and should involve partners.
The acoustic behaviour of resident bottlenose dolphins in Fiordland, New Zealand

The bottlenose dolphin Tursiops truncatus is an extremely well-studied species. We have an extensive knowledge of certain aspects of their vocal behaviour, particularly from captive contexts. Bottlenose dolphins produce a rich tapestry of vocalisations, however, which have historically received minimal attention. Resident groups of bottlenose dolphins frequent the waterways of Fiordland in southwest New Zealand. These deep, sheltered fiords are ideally suited for acoustic studies. This thesis presents the first detailed study of bottlenose dolphin acoustics in New Zealand. Both narrowband and broadband systems were used to record the vocalisations of two resident groups. Effort was distributed evenly over three years for both Doubtful Sound and Milford Sound. From 875 recordings, I proposed a repertoire of 15 discrete calls. These categories were subsequently compared using parameters measured from almost 2000 individual vocalisations. Various multivariate techniques revealed some redundancy in the proposed repertoire, and it was subsequently reduced to 12 calls. The 12 call repertoire was compared between the potentially interbreeding populations of Doubtful Sound and Milford Sound. Fiord-specificity was revealed for many of the calls, particularly the sequenced calls and whistles. These differences suggest bottlenose dolphins use dialects, in keeping with studies of killer whales and sperm whales. As Fiordland dolphins are out of sight for 90% of the time, acoustic techniques allow inference in to subsurface behaviour. I investigated sequential relationships among sounds and between sounds and behaviours. Many calls were strongly implicated in social interactions. The vocalisations ratchet, orca and the sequenced calls were associated with periods of conflict. A number of the click-based calls were linked to diving and presumed foraging events. Inference on the functional significance of sounds allowed an interpretation of habitat use. This appears to be the first study relating the entire vocal repertoire of a cetacean population to a complete home range. Areas important for socialising, foraging and resting are proposed. Local management decisions may be well served by this information. This study uses benign techniques to build on previous research in Fiordland, and adds a new dimension to the study of these populations. -------········---------·-----------·--·-·-·----__;;1V
Chemical and Biological Analyses of the Essential Oils and Main Constituents of Piper Species

The essential oils obtained from leaves of Piper duckei and Piper demeraranum by hydrodistillation were analyzed by gas chromatography-mass spectrometry. The main constituents found in P. demeraranum oil were limonene (19.3%) and β-elemene (33.1%) and in P. duckei oil the major components found were germacrene D (14.7%) and trans-caryophyllene (27.1%). P. demeraranum and P. duckei oils exhibited biological activity, with IC50 values between 15 to 76 μg mL−1 against two Leishmania species, P. duckei oil being the most active. The cytotoxicity of the essential oils on mice peritoneal macrophage cells was insignificant, compared with the toxicity of pentamidine. The main mono- and sesquiterpene, limonene (IC50 = 278 μM) and caryophyllene (IC50 = 96 μM), were tested against the strains of Leishmania amazonensis, and the IC50 values of these compounds were lower than those found for the essential oils of the Piper species. The HET-CAM test was used to evaluate the irritation potential of these oils as topical products, showing that these oils can be used as auxiliary medication in cases of cutaneous leishmaniasis, with less side effects and lower costs.
Work Values, Job Involvement, and Organizational Commitment in Taiwanese Nurses

Employees' belief in the traditional work ethics of hard work and diligence as virtues in their own right has significantly declined in recent times in Taiwan. Job involvement as a mediator of the influence of work values on organiza- tional commitment remains unclear, and needs to be explored in a non-western work context. In addition, the degree of or- ganizational commitment has not been shown to be related to the actual amount of nursing work or labor intensity required in any nursing care environment. This study investigates the relationship between work values, job involvement and organiza- tional commitment in a sample of 1047 Taiwanese nurses from Taiwan. The study utilizes a cross-sectional survey design. The sample consisted of Registered Nurses (RNs) (N=1,047) recruited from a convenience sample in nine regional and teaching hospitals in Taiwan. Results showed that work values were positively related to job involvement and organizational commitment, and job involvement is positively related to organizational commitment. Subsequent analyses revealed that job involvement could play an important role in mediation, and that establishing a higher level of job involvement may be more important than focusing only on organizational commitment. This study has implications for organizations attempting to enhance organizational commitment through increased job involvement. It is anticipated that by improving these various factors, the turnover and absenteeism will be reduced and the organizations become more effective and productive.
Electric field control of magnetism in multiferroic heterostructures

We review the recent developments in the electric field control of magnetism in multiferroic heterostructures, which consist of heterogeneous materials systems where a magnetoelectric coupling is engineered between magnetic and ferroelectric components. The magnetoelectric coupling in these composite systems is interfacial in origin, and can arise from elastic strain, charge, and exchange bias interactions, with different characteristic responses and functionalities. Moreover, charge transport phenomena in multiferroic heterostructures, where both magnetic and ferroelectric order parameters are used to control charge transport, suggest new possibilities to control the conduction paths of the electron spin, with potential for device applications.
Immunophenotypic pattern and cytokine profiles of dry type cutaneous leishmaniasis.

BACKGROUND Dry type localized cutaneous leishmaniasis, one of the most prevalent cutaneous parasitic infections in Kerman Province, is presented as a polarized disease in which cytokine profiles secreted by immune cells play a major role in its presentation. In order to clarify the idea, immunohistochemical study of skin biopsies were performed to elucidate the cytokine release capabilities of immune cells. METHODS Skin biopsies of acute, chronic nonlupoid, and chronic lupoid recidivans lesions of dry type localized cutaneous leishmaniasis were studied by immunohistochemical staining methods for immunophenotypic patterns (CD4, CD8, CD14, CD19, CD56, CD11a, CD18, CD1a, HLA-DR, CD54) and cytokines (INF-gamma, IL-12, IL-4, TNF-alpha) released by immune inflammatory cells. RESULTS The descriptive analysis of data showed that the mean percentage of positive immunostained cells of CD4, CD8, and CD14; antigen-presenting cells (CD1a, HLA-DR); and markers of the extravasated positive memory T cells (CD11a, CD18, CD54) are more frequent in lupoid recidivans than in acute active and chronic nonlupoid lesions, in order of frequency. CONCLUSION Based on the results, it seems that Th1-like response is predominant in acute active form and lupoid recidivans while Th2-like response is predominant in chronic nonlupoid lesions. It seems that lupoid recidivans is a type IV hypersensitivity reaction to the reactivation of hidden antigens.
Semen quality of 324 fertile Japanese men.

BACKGROUND A number of studies have indicated regional differences in semen quality. To examine the current status in Japan, we undertook a cross-sectional study on the semen quality of fertile Japanese men for comparison with recent European results. METHODS Semen parameters of 324 fertile men from the Kawasaki/Yokohama area were investigated. The semen parameters were compared with those published for fertile men from four European cities, Copenhagen, Paris, Edinburgh and Turku. RESULTS When adjusting for confounders such as ejaculation abstinence period and age, the lowest sperm concentrations were detected in men from Kawasaki/Yokohama followed by men from Copenhagen, Paris, Edinburgh and Turku, but only the differences between men from Kawasaki/Yokohama and men from Edinburgh and Turku were significant (P=0.0008 and P<0.0001, respectively). Total sperm count, percentage of motile sperm and percentage of normal sperm observed in Kawasaki/Yokohama were significantly lower than those from all European centres except for motile sperm in men from Paris. CONCLUSIONS Japanese fertile men had a semen quality at the level of Danish men, who have been reported to have the lowest among investigated men in Europe. The low level of semen quality of the fertile Japanese men may be due to lifestyle or other environmental factors; however, ethnic differences caused by different genetic variation or combinations cannot be ruled out by this study.
Intravenous clonidine as a part of balanced anaesthesia for controlled hypotension in functional endoscopic sinus surgery: A randomised controled trial

Background and Aims: Controlled hypotension with balanced anaesthesia minimises blood loss. This study was done to evaluate the effectiveness of intravenous clonidine as a single bolus dose to establish controlled hypotension during functional endoscopic sinus surgery (FESS). Methods: This randomised, double-blind, placebo-controlled study was done in a tertiary hospital in India. Sixty American Society of Anesthesiologists physical status I and II patients (18–65 years) undergoing FESS were randomly allocated to one of the two groups. Placebo group (group A, n = 30) received sterile water whereas the clonidine group (group B, n = 30) received 3μg/kg of clonidine intravenously, 30 min prior to induction of anaesthesia. The primary outcome was to achieve a target mean arterial blood pressure (MAP) of 55–65 mmHg intraoperatively. The secondary outcomes measured were requirement of additional fentanyl and metoprolol, intra-operative blood loss, surgeon's opinion on the surgical field, pain, sedation score and complications requiring treatment. Results: Target MAP was easily achieved in clonidine group as against the placebo group (P < 0.001). Significant reduction in intra-operative blood loss (P = 0.0449), a better surgical site scoring (P = 0.02), less requirement of additional hypotensive drugs and good analgesia (P = 0.01) were seen in clonidine group. The complication rates were similar in both the groups. Conclusion: Clonidine is effective in achieving controlled hypotension in patients undergoing FESS. It reduces intra-operative blood loss, requirement of additional hypotensive drugs, improves the surgical field and offers good analgesia without significant side effects.
The Inventory of Motivations for Hospice Palliative Care Volunteerism: A Tool for Recruitment and Retention

Given the essential role of volunteers in hospice palliative care, it would be beneficial to have a recruitment and retention tool that is reliable and valid. To address this gap, the current investigation sought to adapt and extend the Inventory of Motivations for Palliative Care Volunteerism (IMPCV) of Claxton-Oldfield, Jefferies, Fawcett, Wasylkiw, and Claxton-Oldfield.1 The purpose of study 1 was to address methodological concerns of the IMPCV using 141 undergraduate students. After conceptually relevant items were added to the IMPCV, participants indicated the degree of influence each of the motivations would have on their, and another person’s, decision to become a hospice palliative care volunteer. In both cases, 5 internally consistent subscales were identified through principal components analysis: altruism, civic responsibility, self-promotion, leisure, and personal gain. Convergent and discriminant validity were demonstrated using an established measure of empathy. In study 2, 141 hospice palliative care volunteers completed the revised and renamed Inventory of Motivations for Hospice Palliative Care Volunteerism (IMHPCV). Confirmatory factor analysis provided support for the 5-factor structure of the IMHPCV. The authors encourage other researchers to use the IMHPCV as a measurement tool in studying the motivations of hospice palliative care volunteers.
High-Density Lipoprotein and Cardiovascular Risk

Low serum levels of high-density lipoprotein (HDL) are commonly encountered in patients with coronary artery disease (CAD). An example of this type of patient is a 42-year-old white man with a history of sudden-onset angina secondary to a 90% obstructive lesion along the proximal left anterior descending coronary artery. The family history was significant for his father, who died of a myocardial infarction (MI) at age 44 years. The patient underwent percutaneous transluminal angioplasty with stenting but developed in-stent restenosis. He underwent cutting balloon angioplasty and brachytherapy and was asymptomatic for approximately 6 months. The stent then developed a high-grade occlusion with recurrence of angina, and the patient required single-vessel bypass surgery. The patient’s baseline serum lipid profile revealed low-density lipoprotein (LDL) 128 mg/dL, HDL 27 mg/dL, and triglycerides 92 mg/dL. His lipoprotein(a), C-reactive protein, and homocysteine levels were normal. He was not hypertensive, had no impairment of glycemic control, and did not smoke. With a combination of simvastatin 40 mg and niacin (Niaspan; Kos Pharmaceuticals) 1000 mg daily, the patient’s lipid profile improved, with LDL 78 mg/dL, HDL 43 mg/dL, and triglycerides 60 mg/dL. Follow-up stress testing demonstrated normal myocardial perfusion, and the patient has been asymptomatic for 2 years. With few exceptions, low HDL is an independent risk factor for CAD in case-control and prospective observational studies. In contrast, high HDL levels are associated with longevity and are protective against the development of atherosclerotic disease. In the Framingham Study, risk for CAD increases sharply as HDL levels fall progressively below 40 mg/dL.1 In the Quebec Cardiovascular Study, for every 10% reduction in HDL, risk for CAD increased 13%. 2 Many clinicians believe that low HDL is associated with increased CAD risk because it is a marker for hypertriglyceridemia and elevated remnant particle concentrations. The Prospective Cardiovascular Munster …
A methodology for the design of an integrated air stripping/biofiltration process to clean contaminated aquifers

A METHODOLOGY FOR THE DESIGN OF AN INTEGRA FED AIR STRIPPING/BIOFILTRATION PROCESS TO CLEAN CONTAMINATED AQUIFERS by Pothitos Ioannis Stamatiadis This thesis deals with the conceptual design of an integrated air stripping/biofiltration process for cleaning aquifers contaminated with volatile organic pollutants. In this technology, the pollutant is transferred from the aquifer to an air stream which is subsequently treated in a biofilter. The work presented here is an effort to develop a design methodology for the integrated process and suggests a general, quantitative approach which can be used in preliminary technology evaluation. This methodology involves relatively simple equations for the stripping process and detailed (oftentimes complex) models for biofiltration under conditions of continuous variation of the properties of the polluted airstream which is fed to the biofilter. In this thesis, conventional biofilters were considered. These units have a porous organic support for the biofilms and do not involve supply of nutrients to the organisms through a liquid phase. The air stripping process was considered to be either under equilibrium distribution conditions for the pollutant between the aquifer and the air sparged through it, or under conditions deviating from equilibrium. This deviation was expressed through the use of a fraction of the Henry's constant. The proposed methodology was applied to eight different situations (case studies). These involved differences in the equilibrium distribution of the pollutant, and the number and extent of the time periods in which the total remediation time is divided. This division is proposed for maintaining relatively constant pollutant concentrations to the inlet of the biofilter over an extended period of time. Sample calculations have been performed assuming that a constant volume aquifer is contaminated with toluene. The results show that the integrated process can be designed based on predictive engineering models, and that the size of the required biofilter bed and the time frame for decontamination of the aquifer can be very reasonable. A METHODOLOGY FOR THE DESIGN OF AN INTEGRATED AIR STRIPPING/BIOFILTRATION PROCESS TO CLEAN CONTAMINATED AQUIFERS by Pothitos Ioannis Stamatiadis A Thesis Submitted to the Faculty of New Jersey Institute of Technology in Partial Fulfillment of the Requirements for the Degree of Master of Science in Environmental Engineering Department of Civil and Environmental Engineering January 1997
Organizational Characteristics of Successful Innovative Health Care Programs Sustained Over Time

Summary: Sustaining a successful program over times is critical in today's rapidly changing health care environment. This study sought to identify the characteristics of organizations that implemented innovative health programs for older adults and sustained those programs over time. The Gerontological Health Section of the American Public Health Association created an award in 1998, endowed by the Archstone Foundation, to recognize innovative programs providing health and related social support services to older adults. The 20 award winners were interviewed in Fall 2002, using a structured questionnaire based on the conceptual model for sustainability articulated by Shediac-Rizkallah and Bone. 1 The findings provided insights into the importance of leadership, financing, organizational structure, governance, marketing, and evaluation/research.
Electro-acupuncture at Conception and Governor vessels and transplantation of umbilical cord blood-derived mesenchymal stem cells for treating cerebral ischemia/reperfusion injury

Mesenchymal stem cell transplantation is a novel means of treating cerebral ischemia/reperfusion, and can promote angiogenesis and neurological functional recovery. Acupuncture at Conception and Governor vessels also has positive effects as a treatment for cerebral ischemia/reperfusion. Therefore, we hypothesized that electro-acupuncture at Conception and Governor vessels plus mesenchymal stem cell transplantation may have better therapeutic effects on the promotion of angiogenesis and recovery of neurological function than either treatment alone. In the present study, human umbilical cord blood-derived mesenchymal stem cells were isolated, cultured, identified and intracranially transplanted into the striatum and subcortex of rats at 24 hours following cerebral ischemia/reperfusion. Subsequently, rats were electro-acupunctured at Conception and Governor vessels at 24 hours after transplantation. Modified neurological severity scores and immunohistochemistry findings revealed that the combined interventions of electro-acupuncture and mesenchymal stem cell transplantation clearly improved neurological impairment and up-regulated vascular endothelial growth factor expression around the ischemic focus. The combined intervention provided a better outcome than mesenchymal stem cell transplantation alone. These findings demonstrate that electro-acupuncture at Conception and Governor vessels and mesenchymal stem cell transplantation have synergetic effects on promoting neurological function recovery and angiogenesis in rats after cerebral ischemia/reperfusion.