Miracle-dz/UniFAR-FTUs huggingface dataset:
Benchmarking iron dextran sensitivity: reactions requiring resuscitative medication in incident and prevalent patients.

BACKGROUND Reliable information on the incidence of severe reactions to iron dextran is limited. Administration of agents of resuscitation in acute anaphylaxis may serve as a marker to quantify life-threatening adverse drug reactions. METHODS To determine the incidence of the most serious reactions to intravenous (i.v.) iron dextran, we searched the Gambro Healthcare US medical database for evidence of same-day administration of both i.v. iron dextran and parenteral adrenaline, corticosteroids or antihistamines. We confirmed each case as an iron dextran sensitivity reaction by direct inquiry. We also determined the total reported number of suspected adverse iron dextran reactions. RESULTS During the 16 month study period, we determined that 1,066,099 doses of i.v. iron dextran were given to 48,509 patients, including 20,213 patients who had not previously received iron dextran (iron dextran naïve). We identified seven patients who experienced reactions requiring resuscitative agents, all in response to a test dose (five patients) or first therapeutic dose (two patients), and therefore all in the iron-naïve (incident) group. Thus, we found the incidence of iron dextran reactions requiring resuscitative agents to be 0.035% (7 out of 20,213). No reaction was fatal. In a combined group of incident and prevalent patients, we found 337 total reports of suspected adverse reactions to iron dextran, without regard to severity of reaction, yielding an overall per patient adverse drug event (ADE) rate of 0.69% (337 out of 48,509) and per exposure rate of 0.03% (337 out of 1,066,099). CONCLUSIONS The incidence of reactions to iron dextran requiring resuscitative medications, per exposure or per patient, is approximately 0.035%. Reactions of this severity occur after either the test dose or first dose of iron dextran.
Do measures of working memory predict academic proficiency better than measures of intelligence

It is often asserted that working memory predicts more variance in academic proficiency than do measures of intelligence. We used data from three studies to show that the validity of this assertion is highly dependent on the method of analysis. Using the same measures of intelligence, but different measures of working memory and algebraic proficiency, we found working memory provided better explanatory power only when analysis was conducted on the observed variable level. When the same data were analysed using structural equation models, only measures of intelligence had a direct effect on algebraic proficiency. From a theoretical viewpoint, our findings are consistent with a claim that working memory is a constituent component of (fluid) intelligence.
PBP5 Complementation of a PBP3 Deficiency in Enterococcus hirae

ABSTRACT The low susceptibility of enterococci to β-lactams is due to the activity of the low-affinity penicillin-binding protein 5 (PBP5). One important feature of PBP5 is its ability to substitute for most, if not all, penicillin-binding proteins when they are inhibited. That substitution activity was analyzed in Enterococcus hirae SL2, a mutant whose pbp5 gene was interrupted by the nisRK genes and whose PBP3 synthesis was submitted to nisin induction. Noninduced SL2 cells were unable to divide except when plasmid-borne pbp5 genes were present, provided that the PBP5 active site was functional. Potential protein-protein interaction sites of the PBP5 N-terminal module were mutagenized by site-directed mutagenesis. The T167-L184 region (designated site D) appeared to be an essential intramolecular site needed for the stability of the protein. Mutations made in the two globular domains present in the N-terminal module indicated that they were needed for the suppletive activity. The P197-N209 segment (site E) in one of these domains seemed to be particularly important, as single and double mutations reduced or almost completely abolished, respectively, the action of PBP5.
Convergent Effects of Resveratrol and PYK2 on Prostate Cells

Resveratrol, a dietary polyphenol, is under consideration as chemopreventive and chemotherapeutic agent for several diseases, including cancer. However, its mechanisms of action and its effects on non-tumor cells, fundamental to understand its real efficacy as chemopreventive agent, remain largely unknown. Proline-rich tyrosine kinase 2 (PYK2), a non-receptor tyrosine kinase acting as signaling mediator of different stimuli, behaves as tumor-suppressor in prostate. Since, PYK2 and RSV share several fields of interaction, including oxidative stress, we have investigated their functional relationship in human non-transformed prostate EPN cells and in their tumor-prone counterpart EPN-PKM, expressing a PYK2 dead-kinase mutant. We show that RSV has a strong biological activity in both cell lines, decreasing ROS production, inducing morphological changes and reversible growth arrest, and activating autophagy but not apoptosis. Interestingly, the PYK2 mutant increases basal ROS and autophagy levels, and modulates the intensity of RSV effects. In particular, the anti-oxidant effect of RSV is more potent in EPN than in EPN-PKM, whereas its anti-proliferative and pro-autophagic effects are more significant in EPN-PKM. Consistently, PYK2 depletion by RNAi replicates the effects of the PKM mutant. Taken together, our results reveal that PYK2 and RSV act on common cellular pathways and suggest that RSV effects on prostate cells may depend on mutational-state or expression levels of PYK2 that emerges as a possible mediator of RSV mechanisms of action. Moreover, the observation that resveratrol effects are reversible and not associated to apoptosis in tumor-prone EPN-PKM cells suggests caution for its use in humans.
Towards 'operating within' the field: doctoral students' views of supervisors' discipline expertise

Aim/Purpose: This paper considers the role of supervisors’ discipline expertise in doctoral learning from a student perspective. Background: Doctoral students need to develop expertise in a particular field of study. In this context, developing expertise requires doctoral students to master disciplinary knowledge, conventions and scholarship under the guidance of supervisors. Methodology: The study draws on a mixed-method approach, using an online survey and semi-structured interviews conducted with doctoral students. Contribution: The paper brings to the fore the role of supervisors’ discipline expertise on doctoral students’ research progress. Findings: The survey data suggest that doctoral students nominate their supervisors on the basis of their discipline expertise. They also view supervisors’ expertise as key to the development of ‘insider’ knowledge of their doctoral research. Recommendations for Practitioners: Supervisors play a pivotal role in helping doctoral students overcome intellectual barriers by imparting their discipline knowledge as well as balancing satisfactory doctoral completion rate and high quality student experience. Impact on Society: Doctoral supervision equips doctoral students with the right arsenal to be able to competently operate within their field and prepares them for their future research or professional career that demands a high level of discipline expertise. Future Research: The scope of the findings leaves open a discussion about the experiences of doctoral students matched with non-discipline expert supervisory teams; for example, the extent of the mismatch and its ramifications.
Occupational stress, supervisor support, job satisfaction, and work-related burnout: perceptions of Turkish National Police (TNP) members

Abstract The present study examines whether, and to what degree, occupational stress in law enforcement is associated with job satisfaction, work-related burnout, and supervisor support. A total of 538 Turkish National Police (TNP) members form seven cities in Turkey completed the study survey. The results of the study indicate that the more TNP members experience their organization as stress inducing, the lower their job satisfaction levels, and the higher their burnout levels. Perceived operational stress was found to be significantly associated with their work-related burnout, but not with their job satisfaction. This study also suggests that there is an indirect causal effect of both organizational and operational stress on job satisfaction via supervisor support as mediator. Overall, the findings of this study illustrate a need for internal policy reform and managerial change in how the executives of TNP organize their agency and policies since organizational stressors are the most prevalent factors determining the work-related wellbeing of TNP members.
Taiwanese EFL undergraduates’ self-regulated learning with and without technology

ABSTRACT This study explored 42 English as a foreign language (EFL) undergraduates’ self-regulated learning with and without technology in a university in northwest Taiwan. Based on the conceptual framework on Zimmerman’s (Zimmerman, B. J. 2000. “Attaining Self-regulation: A Social Cognitive Perspective.” In Handbook of Self-Regulation: Theory, Research, and Applications, edited by M. Boekaerts, P. R. Pintrich, and M. Zeidner, 13–39. San Diego, CA: Academic Press) self-regulated learning model, the data analysis of the participants’ final projects, videos of self-regulated learning, and questionnaire concluded the following two major findings. First, participants’ instructional strategies for self-regulated learning followed the 3Ps, presentation, practice, and production. Second, participants regarded instructional strategies without technology as more effective, compared to those implemented with online resources and Apps. Third, age, gender, English proficiency, and age that participants began to learn English did not affect the effectiveness of instructional strategies designed without technology, with online resources and Apps. Suggestions on effective designs for instructional strategies based on without technology, with online resources, and with Apps were provided.
Managing police personnel for effective crime control in Nigeria

This study examines the ways in which police authorities manage their personnel, as well as the factors militating against police authorities in managing their personnel for effective crime control and prevention in Nigeria. The study used both quantitative and qualitative designs to attempt to identify the criteria used in posting police officers. Data were obtained through questionnaires from 360 randomly selected respondents complemented by 15 in-depth interviews (IDI) undertaken in three geo-political regions in Nigeria namely: southeast, southwest and north central. The three geo-political regions were purposively chosen based on the incidences of armed robbery recorded in each. The study also used secondary data sourced from the National Bureau of Statistics and the Nigeria Police Force as reference materials. Simple percentages and chi-squared tests were employed to analyse the collected data. The qualitative data were content analysed. The findings revealed that factors such as crime rate, population size, industrial development and land mass or political interference were not clearly defined criteria used in the posting of personnel. The number of police in a region does not equate to more or less crime; effective crime control and prevention depend on proper and effective utilization, as well as management, of police personnel. Police authorities are culpable of mismanagement of police personnel for personal gain to the detriment of citizens; most states are under-policed and under-staffed. This study also found that factors militating against the effective utilization and management of police personnel include: corruption, political interference, ethno-religious consideration, lack of funds and lack of facilities. Thus, the study recommends among other things, that the distribution of police personnel should be anchored to the population size, industrialization and volume of criminality in a particular place; there should be a gross reduction in the numbers of personnel attached to political officials, whereas those attached to individuals who are not entitled to personal police protection must be withdrawn and efforts made to recruit more people into the police force.
Method to assess the temporal persistence of potential biometric features: Application to oculomotor, gait, face and brain structure databases

We introduce the intraclass correlation coefficient (ICC) to the biometric community as an index of the temporal persistence, or stability, of a single biometric feature. It requires, as input, a feature on an interval or ratio scale, and which is reasonably normally distributed, and it can only be calculated if each subject is tested on 2 or more occasions. For a biometric system, with multiple features available for selection, the ICC can be used to measure the relative stability of each feature. We show, for 14 distinct data sets (1 synthetic, 8 eye-movement-related, 2 gait-related, and 2 face-recognition-related, and one brain-structure-related), that selecting the most stable features, based on the ICC, resulted in the best biometric performance generally. Analyses based on using only the most stable features produced superior Rank-1-Identification Rate (Rank-1-IR) performance in 12 of 14 databases (p = 0.0065, one-tailed), when compared to other sets of features, including the set of all features. For Equal Error Rate (EER), using a subset of only high-ICC features also produced superior performance in 12 of 14 databases (p = 0. 0065, one-tailed). In general, then, for our databases, prescreening potential biometric features, and choosing only highly reliable features yields better performance than choosing lower ICC features or than choosing all features combined. We also determined that, as the ICC of a group of features increases, the median of the genuine similarity score distribution increases and the spread of this distribution decreases. There was no statistically significant similar relationships for the impostor distributions. We believe that the ICC will find many uses in biometric research. In case of the eye movement-driven biometrics, the use of reliable features, as measured by ICC, allowed to us achieve the authentication performance with EER = 2.01%, which was not possible before.
Tarak Chandra Das: A Marginalised Anthropologist

Tarak Chandra Das (1898–1964) was a brilliant social anthropologist who, despite his exemplary social commitment and groundbreaking contributions, remained a marginalised and forgotten personality. The dictionary writers, biographers, and syllabus makers of Indian anthropology have generally neglected Das and his application-oriented contributions on nation-building, ecology, and the Bengal famine that went beyond the simple descriptive studies on tribes, castes, and villages. An evaluation of his contributions is made in this paper.
Elements Of Statistics With Applications To Economics And The Social Sciences

Thank you for downloading elements of statistics with applications to economics and the social sciences. As you may know, people have search numerous times for their favorite readings like this elements of statistics with applications to economics and the social sciences, but end up in harmful downloads. Rather than enjoying a good book with a cup of tea in the afternoon, instead they cope with some malicious bugs inside their computer.
Noncommutative geometry and gravity

We study a deformation of infinitesimal diffeomorphisms of a smooth manifold. The deformation is based on a general twist. This leads to a differential geometry on a noncommutative algebra of functions whose product is a star product. The class of noncommutative spaces studied is very rich. Non-anticommutative superspaces are also briefly considered. The differential geometry developed is covariant under deformed diffeomorphisms and is coordinate independent. The main target of this work is the construction of Einstein's equations for gravity on noncommutative manifolds.
Association between schoolwide positive behavioural interventions and supports and academic achievement: a 9-year evaluation

ABSTRACT This study evaluated the long-term impact of schoolwide positive behavioural interventions and supports (PBIS) on student academic achievement. In this quasi-experimental study, academic achievement data were collected over 9 years. The 21 elementary, middle, and high schools that achieved moderate to high fidelity to the Save & Civil Schools’ PBIS model were matched with 28 control schools to assess academic gains. There were 5 years of baseline data (no intervention in treatment schools) and 4 years of intervention data, including 1 year of maintenance. Results indicate that implementation of the PBIS programme was significantly associated with increased student academic achievement (p = .001) and that the rate of change for students’ academic achievement in treatment schools was greater than for students in control schools. This study suggests that PBIS programmes, such as Safe & Civil Schools’ Foundations, may complement other efforts to improve academic outcomes.
Investigating the Influence of Employee Attitude toward Change and Leadership Style on Change Readiness by SEM (Case Study: Isfahan Municipality)

Change has become a normal occurrence within organizations and especially municipalities, due to the rapid society and economic changes. In a competitive global economy, organizations are forced to stay abreast with environmental changes in order to survive. Employee readiness for change can be a determining factor of successful change. To recognize antecedents of change readiness, the present study has conducted two variables of employee's attitude toward change as individual aspect and leadership style as organizational aspect of change readiness. The hypotheses have been tested by SEM on sample case of Isfahan municipality as a powerful organization which deals with change. The results have indicated that there are positive significant relationships between employee's attitude toward change and employee readiness and also change-oriented leadership style and employee readiness.
Effects of diversity versus segregation on automatic approach and avoidance behavior towards own and other ethnic groups

We present the results of a study in which we measured automatic intergroup behavior and evaluations in ethnic majority and minority group members. We focus our attention on the level of segregation and diversity of immediate life contexts as indicators of outgroup exposure. Specifically, Dutch ethnic minority and majority students enrolled at ethnically segregated and diverse schools completed a measure of automatic approach and avoidance behavior and reported explicit intergroup attitudes. The research is framed into prevailing theories in the field: Social Identity Theory and System Justification Theory. Results of our study suggest that segregation of minority group members' immediate life context may be an important moderator of evaluations as well as approach and avoidance behavior toward ingroup and outgroup. In particular, minority members in segregated schools showed an approach bias towards their ingroup, whereas minority members in diverse schools showed an approach bias towards the majority outgroup.
A Practical Tutorial on Conducting Meta-Analysis in R

Meta-analysis is a set of statistical procedures used for providing transparent, objective, and replicable summaries of research findings. This tutorial demonstrates the most common procedures on conducting a meta-analysis using the R statistical software program. It begins with an introduction to meta-analysis along with detailing the preliminary steps involved in completing a research synthesis. Then, a step-by-step tutorial for each of the quantitative components involved for meta-analysis is provided using a fictional set of psychotherapy treatment-control studies as a running example.
Lyα-EMITTING GALAXIES AT REDSHIFT z∼ 4.5 IN THE LALA CETUS FIELD

We present a large sample of Lyα-emitting galaxies (LAEs) spectroscopically confirmed at redshift z ≈ 4.5, based on Inamori-Magellan Areal Camera and Spectrograph spectroscopic observations of candidate z≈ 4.5 Lyα-emitting galaxies in the large area Lyman alpha (LALA) narrowband imaging survey Cetus field. We identify 110 of them as z ≈ 4.5 Lyα emitters based on single-line detections with no continuum emission blueward of the line. Six foreground galaxies are identified, either based on multiple lines or blueward continuum emission. The Lyα confirmation rate varies from <50% to 76% for candidates selected in different narrowband filters at slightly different redshifts. We find a drop in the LAE density at redshift 4.50 ± 0.03 from redshift 4.39 to 4.47 by a factor of 66%, which could be a large-scale void in the distribution of star-forming galaxies (∼18 Mpc along the line of sight and ∼80 Mpc across). The sample includes many objects with equivalent widths (EWs) ≳200 Å. These large EW candidates are spectroscopically confirmed at the same rate as candidates with more modest EWs. A composite spectrum of all 110 confirmed LAEs shows the characteristic asymmetry of the Lyα line. It also places new and stringent upper limits on the C iv 1549 Å/Lyα and He ii 1640 Å/Lyα line ratios, providing a new upper limit on the fraction of active galactic nuclei in Lyα selected galaxy samples, and on the contribution of Pop III populations. Finally, we calculate the Lyα luminosity function for our z ≈ 4.5 sample, which is consistent with those at other redshifts, showing that there is no evolution in Lyα luminosity function from z = 3.1 to 6.6.
A mechanism of restricted human immunodeficiency virus type 1 expression in human glial cells

We characterized in detail the life cycle of human immunodeficiency virus type 1 (HIV-1) in human glioma H4/CD4 cells which stably express transfected CD4 DNA (B. Volsky, K. Sakai, M. Reddy, and D. J. Volsky, Virology 186:303-308, 1992). Infection of cloned H4/CD4 cells with the N1T strain of cell-free HIV-1 (HIV-1/N1T) was rapid and highly productive as measured by the initial expression of viral DNA, RNA, and protein, but all viral products declined to low levels by 14 days after infection. Chronically infected, virus-producing H4/CD4 cells could be obtained by cell cloning, indicating that HIV-1 DNA can integrate and remain expressed in these cells. The HIV-1 produced in H4/CD4 cells was noninfectious to glial cells, but it could be transmitted with low efficiency to CEM cells. Examination of viral protein composition by immunoprecipitation with AIDS serum or anti-gp120 antibody revealed that HIV-1/N1T-infected H4/CD4 cells produced all major viral proteins including gp160, but not gp120. Deglycosylation experiments with three different glycosidases determined that the absence of gp120 was not due to aberrant glycosylation of gp160, indicating a defect in gp160 proteolytic processing. Similar results were obtained in acutely and chronically infected H4/CD4 cells. To determine the generality of this HIV-1 replication phenotype in H4/CD4 cells, nine different viral clones were tested for replication in H4/CD4 cells by transfection. Eight were transiently productive like N1T, but one clone, NL4-3, established a long-lived productive infection in H4/CD4 cells, produced infectious progeny virus, and produced both gp160 and gp120. We conclude that for most HIV-1 strains tested, HIV-1 infection of H4/CD4 is restricted to a single cycle because of the defective processing of gp160, resulting in the absence of gp120 on progeny virus.