Miracle-dz/UniFAR-FTUs huggingface dataset:
Tobacco smoking and risk of multiple myeloma: A meta‐analysis of 40 observational studies

This meta‐analysis aims to quantitatively synthesize all available data on the association between tobacco smoking and multiple myeloma (MM) risk. Eligible studies were identified and pooled effect estimates (odds ratios and relative risks) were calculated regarding ever, current and former smoking. Separate analyses were performed on case–control and cohort studies, as well as on males and females. Meta‐regression analysis with percentage of males, mean age, years of smoking, pack‐years, cigarettes per day, years since quit and age at onset was performed. Forty articles were deemed eligible; of them 27 used a case–control design (4,625 cases and 21,591 controls) and 13 used a cohort design (2,228 incident cases among a total cohort size equal to 1,852,763 subjects). Ever smoking was not associated with MM risk (pooled effect estimate = 0.92, 95% confidence interval (CI): 0.85–1.00); similar results were obtained for current (pooled effect estimate = 0.87, 95% CI: 0.74–1.03) and former smoking (pooled effect estimate = 1.04, 95% CI: 0.96–1.13). Regarding ever smoking, the null association was reproducible upon cohort studies (pooled effect estimate = 1.01, 95%CI: 0.89–1.15), whereas the inverse association in case–control studies (pooled effect estimate = 0.87, 95% CI: 0.78–0.96) was particularly due to the bias‐prone hospital‐based ones. Meta‐regression analysis did not yield statistically significant results. In conclusion, MM does not seem to be associated with tobacco smoking. There is a need to further explore how molecular mechanisms are involved in the resistance of MM progenitor cells toward smoking.
Whole genomewide linkage screen for neural tube defects reveals regions of interest on chromosomes 7 and 10

Neural tube defects (NTDs) are the second most common birth defects (1 in 1000 live births) in the world. Periconceptional maternal folate supplementation reduces NTD risk by 50–70%; however, studies of folate related and other developmental genes in humans have failed to definitively identify a major causal gene for NTD. The aetiology of NTDs remains unknown and both genetic and environmental factors are implicated. We present findings from a microsatellite based screen of 44 multiplex pedigrees ascertained through the NTD Collaborative Group. For the linkage analysis, we defined our phenotype narrowly by considering individuals with a lumbosacral level myelomeningocele as affected, then we expanded the phenotype to include all types of NTDs. Two point parametric analyses were performed using VITESSE and HOMOG. Multipoint parametric and nonparametric analyses were performed using ALLEGRO. Initial results identified chromosomes 7 and 10, both with maximum parametric multipoint lod scores (Mlod) >2.0. Chromosome 7 produced the highest score in the 24 cM interval between D7S3056 and D7S3051 (parametric Mlod 2.45; nonparametric Mlod 1.89). Further investigation demonstrated that results on chromosome 7 were being primarily driven by a single large pedigree (parametric Mlod 2.40). When this family was removed from analysis, chromosome 10 was the most interesting region, with a peak Mlod of 2.25 at D10S1731. Based on mouse human synteny, two candidate genes (Meox2, Twist1) were identified on chromosome 7. A review of public databases revealed three biologically plausible candidates (FGFR2, GFRA1, Pax2) on chromosome 10. The results from this screen provide valuable positional data for prioritisation of candidate gene assessment in future studies of NTDs.
Alterations in tissue aerobic capacity may play a role in premigratory fattening in shorebirds

Migratory shorebirds show regulated seasonal increases in body mass (BM) even in captivity, consisting primarily, but not exclusively, of fat. We examined whether captive red knot (Calidris canutus) exhibited seasonal alterations in mitochondrial volume (liver, pectoral muscle) and/or succinate dehydrogenase (SDH) activity (liver, pectoral muscle, heart, small intestine) during three distinct life-cycle stages: stable BM, spring peak in BM, and as BM rapidly declined after the spring peak. Mitochondrial volume in liver and pectoral muscle and SDH activity in liver and heart did not alter with life-cycle stage. However, red knot undergoing premigratory fattening exhibited significantly lower pectoral muscle SDH activity in concert with significantly elevated activity in the small intestine compared with the other two time-points, suggesting that tissue metabolic rate alters with life-cycle stage. The increased intestinal SDH activity may indicate an elevation in energy assimilation at a time when intestine hypertrophy occurs, thus maximizing BM increase prior to putative migration. The concomitant decrease in pectoral muscle activity may act to reduce overall metabolic rate, or at least help counter the elevation in intestinal mass-specific metabolic rate. Both tissues hypertrophy prior to migration in wild red knot, but hypertrophy of the intestine precedes that of pectoral muscle. Indeed, it appears that the intestinal mass undergoes atrophy by the time pectoral muscle hypertrophy occurs in wild red knot. Thus, physiological adjustments in tissue metabolism may be an important factor in the life-history strategies of migrating shorebirds.
A survey of inter-domain peering and provisioning solutions for the next generation optical networks

The emergence of carrier grade transport technologies has led to a paradigm shift in inter-domain routing which became an important feature of the transport layer based on optical transmission and switching. While the new technologies have capabilities to provide end-to-end guaranteed quality of service (QoS), the lack of inter-operability between different technologies, administrative areas and control planes makes interdomain peering and provisioning below the conventional Internet Protocol (IP) layer a challenge. In this survey, we analyze various multi-domain routing models for emerging Layer 2 and WDM switched networks which have been proposed till date, and based on that survey, we highlight some open issues and future challenges pertaining to scalability, reliability, multi-domain QoS, control plane interworking and dynamic peering.
Rapid communications Avian influenza A ( H 10 N 7 ) virus involvement in mass mortality of harbour seals ( Phoca vitulina ) in Sweden , March through October 2014

S Zohari (siamak.zohari@sva.se)1, A Neimanis2, T Härkönen3, C Moraeus3, J F Valarcher1 1. Department of Virology, Immunobiology and Parasitology, National Veterinary Institute, Uppsala, Sweden 2. Department of Pathology and Wildlife Diseases, Wildlife Section, National Veterinary Institute, Uppsala, Sweden 3. Department of Environmental Research and Monitoring, Swedish Museum of Natural History, Stockholm, Sweden
Nonlinear nonconservative behavior and modeling of piezoelectric energy harvesters including proof mass effects

Nonlinear piezoelectric effects in flexural energy harvesters have recently been demonstrated for drive amplitudes well within the scope of anticipated vibration environments for power generation. In addition to strong softening effects, steady-state oscillations are highly damped as well. Nonlinear fluid damping was previously employed to successfully model drive dependent decreases in frequency response due to the high-velocity oscillations, but this article instead harmonizes with a body of literature concerning weakly excited piezoelectric actuators by modeling nonlinear damping with nonconservative piezoelectric constitutive relations. Thus, material damping is presumed dominant over losses due to fluid-structure interactions. Cantilevers consisted of lead zirconate titanate (PZT)-5A and PZT-5H are studied, and the addition of successively larger proof masses is shown to precipitate nonlinear resonances at much lower base excitation thresholds while increasing the influence of higher-order nonlinearities. Parameter identification results using a multiple scales perturbation solution suggest that empirical trends are primarily due to higher-order elastic and dissipation nonlinearities and that modeling linear electromechanical coupling is sufficient. This article concludes with the guidelines for which utilization of a nonlinear model is preferred.
A Computational Account of the Development of the Generalization of Shape Information

Abecassis, Sera, Yonas, and Schwade (2001) showed that young children represent shapes more metrically, and perhaps more holistically, than do older children and adults. How does a child transition from representing objects and events as undifferentiated wholes to representing them explicitly in terms of their attributes? According to RBC (Recognition-by-Components theory; Biederman, 1987), objects are represented as collections of categorical geometric parts ("geons") in particular categorical spatial relations. We propose that the transition from holistic to more categorical visual shape processing is a function of the development of geon-like representations via a process of progressive intersection discovery. We present an account of this transition in terms of DORA (Doumas, Hummel, & Sandhofer, 2008), a model of the discovery of relational concepts. We demonstrate that DORA can learn representations of single geons by comparing objects composed of multiple geons. In addition, as DORA is learning it follows the same performance trajectory as children, originally generalizing shape more metrically/holistically and eventually generalizing categorically.
Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): A double-edged sword?

Identification of cell signaling mechanisms mediating seizure-related neuronal death and epileptogenesis is important for developing more effective therapies for epilepsy. The mammalian target of rapamycin (mTOR) pathway has recently been implicated in regulating neuronal death and epileptogenesis in rodent models of epilepsy. In particular, kainate-induced status epilepticus causes abnormal activation of the mTOR pathway, and the mTOR inhibitor, rapamycin, can decrease the development of neuronal death and chronic seizures in the kainate model. Here, we discuss the significance of these findings and extend them further by identifying upstream signaling pathways through which kainate status epilepticus activates the mTOR pathway and by demonstrating limited situations where rapamycin may paradoxically increase mTOR activation and worsen neuronal death in the kainate model. Thus, the regulation of seizure-induced neuronal death and epileptogenesis by mTOR is complex and may have dual, opposing effects depending on the physiological and pathological context. Overall, these findings have important implications for designing potential neuroprotective and antiepileptogenic therapies that modulate the mTOR pathway.
The Hospital Dementia Services Project: age differences in hospital stays for older people with and without dementia

ABSTRACT Background: People with dementia may have adverse outcomes following periods of acute hospitalization. This study aimed to explore the effects of age upon hospitalization outcomes for patients with dementia in comparison to patients without dementia. Methods: Data extracted from the New South Wales Admitted Patient Care Database for people aged 50 years and over for the period July 2006 to June 2007 were linked to create person-based records relating to both single and multiple periods of hospitalization. This yielded nearly 409,000 multi-day periods of hospitalization relating to almost 253,000 persons. Using ICD-10-AM codes for dementia and other principal diagnoses, the relationship between age and hospitalization characteristics were examined for people with and without dementia. Results: Dementia was age-related, with 25% of patients aged 85 years and over having dementia compared with 0.9% of patients aged 50–54 years. People with dementia were more likely to be admitted for fractured femurs, lower respiratory tract infections, urinary tract infections and head injuries than people without dementia. Mean length of stay for admissions for people with dementia was 16.4 days and 8.9 days for those without dementia. People with dementia were more likely than those without to be re-admitted within three months for another multi-day stay. Mortality rates and transfers to nursing home care were higher for people with dementia than for people without dementia. These outcomes were more pronounced in younger people with dementia. Conclusion: Outcomes of hospitalization vary substantially for patients with dementia compared with patients without dementia and these differences are frequently most marked among patients aged under 65 years.
Quantifying cerebral asymmetries for language in dextrals and adextrals with random-effects meta analysis

Speech and language-related functions tend to depend on the left hemisphere more than the right in most right-handed (dextral) participants. This relationship is less clear in non-right handed (adextral) people, resulting in surprisingly polarized opinion on whether or not they are as lateralized as right handers. The present analysis investigates this issue by largely ignoring methodological differences between the different neuroscientific approaches to language lateralization, as well as discrepancies in how dextral and adextral participants were recruited or defined. Here we evaluate the tendency for dextrals to be more left hemisphere dominant than adextrals, using random effects meta analyses. In spite of several limitations, including sample size (in the adextrals in particular), missing details on proportions of groups who show directional effects in many experiments, and so on, the different paradigms all point to proportionally increased left hemispheric dominance in the dextrals. These results are analyzed in light of the theoretical importance of these subtle differences for understanding the cognitive neuroscience of language, as well as the unusual asymmetry in most adextrals.
Stellar wind–magnetosphere interaction at exoplanets: computations of auroral radio powers

We present calculations of the auroral radio powers expected from exoplanets with magnetospheres driven by an Earth-like magnetospheric interaction with the solar wind. Specifically, we compute the twin cell-vortical ionospheric flows, currents, and resulting radio powers resulting from a Dungey cycle process driven by dayside and nightside magnetic reconnection, as a function of planetary orbital distance and magnetic field strength. We include saturation of the magnetospheric convection, as observed at the terrestrial magnetosphere, and we present power-law approximations for the convection potentials, radio powers and spectral flux densities. We specifically consider a solar-age system and a young (1 Gyr) system. We show that the radio power increases with magnetic field strength for magnetospheres with saturated convection potential, and broadly decreases with increasing orbital distance. We show that the magnetospheric convection at hot Jupiters will be saturated, and thus unable to dissipate the full available incident Poynting flux, such that the magnetic Radiometric Bode's Law (RBL) presents a substantial overestimation of the radio powers for hot Jupiters. Our radio powers for hot Jupiters are ∼5–1300 TW for hot Jupiters with field strengths of 0.1–10 B J orbiting a Sun-like star, while we find that competing effects yield essentially identical powers for hot Jupiters orbiting a young Sun-like star. However, in particular, for planets with weaker magnetic fields, our powers are higher at larger orbital distances than given by the RBL, and there are many configurations of planet that are expected to be detectable using SKA.
Sexually Transmitted Disease Management in Uganda’s Private-for-Profit Formal and Informal Sector and Compliance With Treatment

Objective: The objective of this study was to investigate the management of sexually transmitted diseases (STDs) in the Ugandan private sector clinics and drug shops. Study: Men with urethral discharge who had consulted clinics (264) or drug shops (141) for treatment in 5 districts were interviewed using a precoded questionnaire 1 to 3 weeks after initiation of treatment. Results: Seventy-seven percent of patients sought treatment within 1 week of onset of symptoms but only 7% were properly managed (treated according to National Guidelines, told to use a condom or abstain, and to refer their partner). The reported cure rate was 47% and only 9% were treated according to National Guidelines. Eighteen percent of patients used condoms during treatment, 36% persuaded their partner to go for treatment, and 87% completed the recommended treatment course. Of patients not reporting cure, 56% would still recommend the treatment to a friend. Conclusion: Quality of STD management by private providers is poor. Improvement should occur concurrently at public and private facilities. Possible strategies include training and social marketing of prepackaged treatment for STDs.
the Internet of Things: a Systematic Literature Review

—In the Internet of Things (IoT) scenario, the block-chain and, in general, Peer-to-Peer approaches could play an important role in the development of decentralized and data-intensive applications running on billion of devices, preserving the privacy of the users. Our research goal is to understand whether the blockchain and Peer-to-Peer approaches can be employed to foster a decentralized and private-by-design IoT. As a ﬁrst step in our research process, we conducted a Systematic Literature Review on the blockchain to gather knowledge on the current uses of this technology and to document its current degree of integrity, anonymity and adaptability. We found 18 use cases of blockchain in the literature. Four of these use cases are explicitly designed for IoT. We also found some use cases that are designed for a private-by-design data management. We also found several issues in the integrity, anonymity and adaptability. Regarding anonymity, we found that in the blockchain only pseudonymity is guaranteed. Regarding adaptability and integrity, we discovered that the integrity of the blockchain largely depends on the high difﬁculty of the Proof-of-Work and on the large number of honest miners, but at the same time a difﬁcult Proof-of-Work limits the adaptability. We documented and categorized the current uses of the blockchain, and provided a few recommendations for future work to address the above-mentioned issues.
Effects of Hand-Rearing on Reproductive Success in Captive Large Cats Panthera tigris altaica, Uncia uncia, Acinonyx jubatus and Neofelis nebulosa

Species Survival Plans and European Endangered Species Programmes have been developed for several species of endangered felids in order to build up captive reserve populations and support their conservation in the wild. The Siberian tiger (Panthera tigris altaica), snow leopard (Uncia uncia), cheetah (Acinonyx jubatus) and clouded leopard (Neofelis nebulosa) are managed in such ex situ conservation programmes. Many zoological institutions hand-rear offspring if rearing by the mother fails. Hand-rearing can cause behavioural problems, resulting in decreased copulation and lower breeding success in some species. In this study, studbook data subsets were examined: from 1901 to 2011; and 2000 to 2011. We analysed records from 4273 Siberian tigers, 2045 snow leopards, 3435 cheetahs, and 804 clouded leopards. We assessed the number of offspring produced, litter size, age at first reproduction, longevity, infant mortality and generational rearing of hand-reared versus parent-reared individuals. Hand-reared Siberian tigers (p<0.01; p = 0.0113), snow leopards (p<0.01), male cheetahs (p<0.01) and female clouded leopards (p<0.01) produced fewer offspring than parent-reared individuals. Hand-reared snow leopard breeding pairs had larger litters than parent-reared pairs (p = 0.0404). Hand-reared snow leopard females reproduced later in life (p<0.01). Hand-reared female Siberian tigers lived shorter lives, while hand-reared cheetahs lived longer (p<0.01; p = 0.0107). Infant mortality was higher in hand-reared snow leopards (p<0.01) and male cheetahs (p = 0.0395) in the 1901–2011 dataset and lower in hand-reared female Siberian tiger and male snow leopard cubs (p = 0.0404; p = 0.0349) in the 2000–2011 dataset. The rearing of the mother and subsequent rearing of offspring showed a significant relationship for all species (p<0.01 for Siberian tiger and snow leopard cubs; p<0.001 for cheetah and snow leopard cubs). Taking into account the limited carrying capacity of zoos, the results of this study highlight that careful consideration should be taken when deciding whether or not to hand-rear individuals that are part of Species Survival Plans and European Endangered Species Programmes.
Scientists' Uncertainty and Disagreement about Global Climate Change: A Psychological Perspective

Abstract Since there are major gaps in scientific knowledge about the greenhouse effect, policy makers are forced to rely on scientists' judgments about the rate of climate change and its effects. It now appears that significant policy decisions will have to be made despite continuing uncertainty and disagreement among scientists. The best that policy makers can do is look for guidance in the best available expert judgment. But when the best experts express great uncertainty and disagree, as seems to be the case with the greenhouse effect, policy makers are unsure about how to proceed. Despite its importance, scientific judgment about the greenhouse effect has not been systematically studied. Psychological research on expert judgment and decision making provides theory, methods, and empirical results that can be used to study judgments based on uncertain and incomplete data and can help to explain the sources of expert uncertainty and disagreement regarding the greenhouse effect. Possible explanations are.
A Comprehensive Model With Fast Solver for Optimal Energy Scheduling in RTP Environment

In the smart grid environment, demand side management makes it possible to encourage consumers participating more actively via proper pricing schemes. In this paper, we analyze previous real-time pricing models and then provide a comprehensive model. A new criterion for designing real-time pricing models is proposed, which can guarantee that the optimal solution obtained from centralized algorithms is the same as that from the distributed algorithms. Furthermore, a fast distributed dual gradient algorithm is proposed to achieve the optimal solution. Compared with the widely used distributed dual sub-gradient algorithm, theoretically, the proposed one does not only accelerate the convergence rate, but also overcome the possible non-convergence during iteration process, which is a demerit in the traditional method. This new solver is of great importance in the application of dynamic pricing mechanism due to real-time requirement. More specifically, this new algorithm can largely reduce the information exchange between the energy provider and its customers, making the proposed method more practical. The simulations also validate its effectiveness and efficiency in solving real-time pricing problems.