Miracle-dz/UniFAR-FTUs huggingface dataset:
Pain Management of Pediatric Musculoskeletal Injury in the Emergency Department: A Systematic Review

Background. Pain management for children with musculoskeletal injuries is suboptimal and, in the absence of clear evidence-based guidelines, varies significantly. Objective. To systematically review the most effective pain management for children presenting to the emergency department with musculoskeletal injuries. Methods. Electronic databases were searched systematically for randomized controlled trials of pharmacological and nonpharmacological interventions for children aged 0–18 years, with musculoskeletal injury, in the emergency department. The primary outcome was the risk ratio for successful reduction in pain scores. Results. Of 34 studies reviewed, 8 met inclusion criteria and provided data on 1169 children from 3 to 18 years old. Analgesics used greatly varied, making comparisons difficult. Only two studies compared the same analgesics with similar routes of administration. Two serious adverse events occurred without fatalities. All studies showed similar pain reduction between groups except one study that favoured ibuprofen when compared to acetaminophen. Conclusions. Due to heterogeneity of medications and routes of administration in the articles reviewed, an optimal analgesic cannot be recommended for all pain categories. Larger trials are required for further evaluation of analgesics, especially trials combining a nonopioid with an opioid agent or with a nonpharmacological intervention.
The Angiogenic Activity of Ascites in the Course of Ovarian Cancer as a Marker of Disease Progression

Ovarian cancer cells are able to create invasive implants in the peritoneum and their growth is directly associated with the angiogenetic potential. This effect is probably stimulated by vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), which are both found in ascites. The aim of this study was to assess the influence of ascites produced by ovarian cancer on the angiogenesis. Peritoneal fluid was collected from patients with advanced ovarian cancer; cancer cells were separated from CD45+ leukocytes. Angiogenesis was assessed in mice, after intradermal injection of full cellular suspension together with supernatant or phosphate buffered saline, purified cancer cells suspension, or CD45+ leukocytes suspension. The angiogenesis index (AI) was assessed after 72 hours. VEGF and Il-8 were measured in the supernatant and cellular suspension. AI was the highest in the isolated cancer cells suspensions as well in the group stimulated with supernatant. Both VEGF and IL-8 were high in supernatants from ascites rich in cancer cells (>45%). A significant correlation was revealed between IL-8 concentration and AI. We conclude that ascites in patients with advanced ovarian cancer stimulates angiogenesis and this mechanism is dependent mostly on cancer cells activity and enhanced by cooperation with infiltrating leukocytes.
A French Version of the Balanced Time Perspective Scale: Factor Structure and Relation to Cognitive Reappraisal

A frequent and equal tendency to think positively about one’s past and future has been conceptualised as a balanced time perspective (TP). Such a dispositional temporal orientation has been associated with higher life satisfaction and happiness. The aim of the present study was to develop and to validate a French version of the Balanced Time Perspective Scale (BTPS; Webster, 2011), which has been specifically designed to assess the combined use of positive future and past mental representations as resources for the self. Data were collected from an online survey in a sample of 622 French-speaking individuals from the general population. Results indicated that the French version of the BTPS replicated the 2-factor structure of the original questionnaire, and showed excellent internal consistency. External validity was supported by specific relationships with measures of TP and positive affect. In addition, a high propensity to project oneself positively both in the future and the past was associated with greater use of cognitive reappraisal. La tendance fréquente et soutenue à avoir des pensées positives au sujet de son passé et de son avenir a été conceptualisée en la notion de perspective de temps équilibrée. Une telle perspective temporelle a été associée à une plus grande satisfaction à l’égard de la vie ainsi qu’à un plus grand bonheur. Le but de la présente étude était d’établir et de valider une version française de la Balanced Time Perspective Scale (BTPS; Webster, 2011), qui a été conçue spécifiquement pour évaluer l’usage combiné des représentations mentales futures et passées positives en tant que ressources pour soi. Des données ont été amassées au moyen d’un questionnaire en ligne auprès d’un échantillon de 622 francophones dans la population en général. Les résultats ont révélé que la version française de la BTPS répliquait la structure à 2 facteurs du questionnaire original et qu’elle présentait une excellente consistance interne. Sa validité externe a été confirmée par des relations précises avec des mesures de la perspective de temps et d’affects positifs. De plus, une forte propension à se projeter positivement à la fois dans l’avenir et dans le passé a été associée à une plus grande utilisation de la réévaluation cognitive.
Traumatic Atlanto-Occipital Dislocation Presenting With Dysphagia as the Chief Complaint: A Case Report

We report a patient with traumatic atlanto-occipital dislocation who presented with dysphagia as the chief complaint. A 59-year-old man complained of swallowing difficulty for 2 months after trauma to the neck. On physical examination, there was atrophy of the right sternocleidomastoid and upper trapezius muscles, and the tongue was deviated to the right. In a videofluoroscopic swallowing study, penetration and aspiration were not seen, food residue remained in the right vallecula and pyriform sinus, and there was decreased motion of the soft palate, pharynx and larynx. Electromyography confirmed a right spinal accessory nerve lesion. Magnetic resonance imaging confirmed atlanto-occipital dislocation. Dysphagia in atlanto-occipital dislocation is induced by medullary compression and lower cranial nerve injury. Therefore, in survivors who are diagnosed with atlanto-occipital dislocation, any neurological symptoms should be carefully evaluated.
Time Banditry as a Coping Mechanism: Emotion-Focused and Problem-Focused Pathways from Stressors to Counterproductive Work Behaviors

OAKLEY, SONIA LAUREN. Time Banditry as a Coping Mechanism: Emotion-Focused and Problem-Focused Pathways from Stressors to Counterproductive Work Behaviors. (Under the direction of Dr. Samuel Pond, III.) This study investigated the mechanisms linking work stressors to time banditry, or unauthorized time-wasting at work. Integrating research on counterproductive work behavior and the stress process, I proposed that employees waste work time to cope with stressful situations. Specifically, I proposed that work stressors induce the formation of two instrumentality perceptions: the perception that time-wasting can help the individual feel better about the stressor (emotion-focused coping instrumentality), and the perception that time-wasting can help the individual resolve the stressor (problem-focused coping instrumentality). In Study 1, I developed two five-item scales for the two types of coping instrumentality, which can assess the usefulness of any behavior for coping with any stressor. In Study 2, I assessed coping instrumentality perceptions for six stressors, along with stressor intensity and time banditry frequency. Survey data from 259 full-time employees confirmed that for three of the six stressors, emotion-focused coping instrumentality mediated a positive relationship between the stressor and time banditry. For the other three stressors, stressor presence was unrelated to emotion-focused coping instrumentality; however, emotionfocused coping instrumentality positively predicted time banditry. These results suggest that employees use time-wasting behavior to ease the anxiety, anger, and other negative emotions associated with work stressors. In contrast, I found no evidence of mediation through problem-focused coping instrumentality for any of the stressors. Together these two studies suggest ways to enhance work productivity, and provide future directions for investigating time-wasting behavior as a coping response. Time Banditry as a Coping Mechanism: Emotion-Focused and Problem-Focused Pathways from Stressors to Counterproductive Work Behaviors by Sonia Lauren Oakley A dissertation submitted to the Graduate Faculty of North Carolina State University in partial fulfillment of the requirements for the degree of Doctor of Philosophy
Looking but Not Seeing

Posterior cortical atrophy (PCA) is the canonical “visual dementia,” with affected individuals experiencing a progressive disintegration of their visual world owing to dysfunction and atrophy at the back of the brain. The syndrome, which also affects literacy, numeracy, and gesture, is typically caused by Alzheimer’s disease, but is distinguished from more common amnestic presentations by virtue of relatively preserved episodic memory and insight. Although problems with object and space perception are the most widely reported and investigated symptoms, these higher-order perceptual difficulties are often underpinned by an array of changes in more basic visual and oculomotor processes. Here we review recent studies providing insights into these more elementary aspects of vision in PCA, including fixation stability, saccade generation, point localization, excessive crowding, and factors affecting the effective field of vision. We argue that a more detailed appreciation of these fundamental changes in the early visual system not only will improve the characterization and understanding of this rare clinico-radiological syndrome but will also guide the design of visual aids and strategies aimed at maintaining everyday abilities in individuals with PCA.
Inactivation of Socs3 in the Hypothalamus Enhances the Hindbrain Response to Endogenous Satiety Signals via Oxytocin Signaling

Leptin is an adipocyte-derived hormone that controls energy balance by acting primarily in the CNS, but its action is lost in common forms of obesity due to central leptin resistance. One potential mechanism for such leptin resistance is an increased hypothalamic expression of Suppressor of cytokine signaling 3 (Socs3), a feedback inhibitor of the Jak-Stat pathway that prevents Stat3 activation. Ample studies have confirmed the important role of Socs3 in leptin resistance and obesity. However, the degree to which Socs3 participates in the regulation of energy homeostasis in nonobese conditions remains largely undetermined. In this study, using adult mice maintained under standard diet, we demonstrate that Socs3 deficiency in the mediobasal hypothalamus (MBH) reduces food intake, protects against body weight gain, and limits adiposity, suggesting that Socs3 is necessary for normal body weight maintenance. Mechanistically, MBH Socs3-deficient mice display increased hindbrain sensitivity to endogenous, meal-related satiety signals, mediated by oxytocin signaling. Thus, oxytocin signaling likely mediates the effect of hypothalamic leptin on satiety circuits of the caudal brainstem. This provides an anatomical substrate for the effect of leptin on meal size, and more generally, a mechanism for how the brain controls short-term food intake as a function of the energetic stores available in the organism to maintain energy homeostasis. Any dysfunction in this pathway could potentially lead to overeating and obesity.
FPGA implementation of a microcoded elliptic curve cryptographic processor

Elliptic curve cryptography (ECC) has been the focus of much recent attention since it offers the highest security per bit of any known public key cryptosystem. This benefit of smaller key sizes makes ECC particularly attractive for embedded applications since its implementation requires less memory and processing power. In this paper a microcoded Xilinx Virtex based elliptic curve processor is described. In contrast to previous implementations, it implements curve operations as well as optimal normal basis field operations in F(2/sup n/); the design is parameterized for arbitrary n; and it is microcoded to allow for rapid development of the control part of the processor. The design was successfully tested on a Xilinx Virtex XCV300-4 and, for n=113 bits, utilized 1290 slices at a maximum frequency of 45 MHz and achieved a thirty-fold speedup over an optimized software implementation.
The Doherty Power Amplifier: Review of Recent Solutions and Trends

In this paper, an extensive review of the most up-to-date papers on microwave Doherty power amplifiers is presented. The main applications are discussed, together with the employed semiconductor technologies. The different research trends, all aimed to improve the advantages of the Doherty scheme and to solve its inherent drawbacks, are presented. The first considered topic is the maximization of efficiency and/or linearity, where analog and digital techniques are exploited. Another important trend is the bandwidth enlargement of the Doherty architecture, that involves a large number of papers. Multi-band, multi-mode solutions are also considered, using either fixed or reconfigurable solutions. The final section is dedicated to the most significant Doherty integrated implementations.
Application of Taguchi Approach for Optimization Roughness for Boring operation of E 250 B0 for Standard IS: 2062 on CNC TC

In this research paper, E 250 B0 as per IS: 2062 steel material are turned on computer numeric controlled (CNC) turning center by using Chemical Vapor Deposition (CVD) coated cemented carbide inserts of 0.8 mm and 1.2 mm. This paper discusses an investigation of effect of process parameters (speed, feed, depth of cut & nose radius) on responding quality parameter (boring operation). This study utilizes a mixed L16 orthogonal array for determining the optimum quality parameters, with an applied noise factor. Excel and Minitab 16.0 software are used for analysis purpose. Analysis of variance (ANOVA) suggested that speed, nose radius and feed are the most significant parameters for boring operation and its percentage contribution 74.92, 11.09 & 11.12 respectively. Mathematical modeling and predication of surface roughness is accomplished by using the regression analysis. The predicted values are conformed by using validation experiments.
An analysis of the role of disgust in five moral domains with relation to gender, religiosity, right-left politics, obsessive beliefs, and cleaning compulsions

V ÖZ. VII ACKNOWLEDGEMENT.IX TABLE OF CONTENTS.XII LIST OF FIGURES.XVI LIST OF TABLES.XVII LIST OF ABBREVIATION.XIX LIST OF SYMBOLS.XX
Can Providing Rubrics for Writing Tasks Improve Developing Writers' Calibration Accuracy?

ABSTRACT Rubric-referenced calibration and the interaction between writing achievement and calibration, a measure of the relationship between one's performance and the accuracy of one's judgments, were investigated. Undergraduate students (N = 596) were assigned to one of three calibration conditions: (a) global, (b) global and general criteria, or (c) global and detailed criteria. Students in all three conditions provided global predictions and postdictions of essay exam scores. Although calibration judgments by condition did not affect calibration accuracy overall, statistically significant main effects were found between calibration accuracy by criteria and prior achievement. High achievers made more-accurate predictions and postdictions by criteria than low achievers. Regardless of achievement level, those students in the detailed rubric condition had higher postdictive accuracy for the organization criteria than did students in the general rubric condition.
When Bigger Is Better (and When It Is Not): Implicit Bias in Numeric Judgments

Numeric ratings for products can be presented using a bigger-is-better format ( 1=bad, 5=good ) or a smaller-is-better format with reversed rating poles ( 1=good, 5=bad ). Seven experiments document how implicit memory for the bigger-is-better format—where larger numbers typically connote something is better—can systematically bias consumers’ judgments without their awareness. This rating polarity effect is the result of proactive interference from culturally determined numerical associations in implicit memory and results in consumer judgments that are less sensitive to differences in numeric ratings. This is an implicit bias that manifests even when people are mindful and focused on the task and across a range of judgment types (auction bids, visual perception, purchase intent, willingness-to-pay). Implicating the role of reliance on implicit memory in this interference effect, the rating polarity effect is moderated by (i) cultural norms that define the implicit numerical association, (ii) construal mindsets that encourage reliance on implicit memory, and (iii) individual propensity to rely on implicit memory. This research identifies a new form of proactive interference for numerical associations, demonstrates how reliance on implicit memory can interfere with explicit memory, and shows how to attenuate such interference.
Adaptive Image-space Stereo View Synthesis

Stereo vision is becoming increasingly popular in feature ﬁlms, visualization and interactive applications such as computer games. However, computation costs are doubled when rendering an individual image for each eye. In this work, we propose to only render a single image, together with a depth buffer and use image-based techniques to generate two individual images for the left and right eye. The resulting method computes a high-quality stereo pair for roughly half the cost of the traditional methods. We achieve this result via an adaptive-grid warping that also involves information from previous frames to avoid artifacts
Tissue-mimicking phantom materials for narrowband and ultrawideband microwave applications

We propose and characterize oil-in-gelatin dispersions that approximate the dispersive dielectric properties of a variety of human soft tissues over the microwave frequency range from 500 MHz to 20 GHz. Different tissues are mimicked by selection of an appropriate concentration of oil. The materials possess long-term stability and can be employed in heterogeneous configurations without change in geometry or dielectric properties due to osmotic effects. Thus, these materials can be used to construct heterogeneous phantoms, including anthropomorphic types, for narrowband and ultrawideband microwave technologies, such as breast cancer detection and imaging systems.
Impact of C-reactive protein and fibrinogen on cardiovascular prognosis in patients with stable angina pectoris: the AtheroGene study.

AIMS C-reactive protein and fibrinogen have been extensively studied and shown to be predictive for a first cardiovascular event in healthy individuals. We evaluated the potential clinical use of C-reactive protein and fibrinogen in patients already suffering from coronary artery disease (CAD). METHODS AND RESULTS In a substudy of the prospective AtheroGene registry, we assessed in 1806 patients with documented CAD and stable angina pectoris, the risk of cardiovascular death and non-fatal myocardial infarction (n=183) over a median follow-up of 3.5 (maximum 7.7) years according to baseline levels of C-reactive protein and fibrinogen. C-reactive protein and fibrinogen were associated with future cardiovascular events, such as an increment in one standard deviation of C-reactive protein is associated with a 1.15-fold (95% CI 1.05-1.27, P=0.002) increase, an increment of one standard deviation of fibrinogen with a 1.27-fold (95% CI 1.12-1.43, P<0.0005) increase in hazard risk in the models adjusted for age and sex. Adjustment for traditional risk factors and clinical confounders did not significantly attenuate this relationship. In a comparison of a basic model (traditional risk factors; AUC=0.68) with models additionally including either C-reactive protein (AUC=0.69) or fibrinogen (AUC=0.70), only little additional predictive information over that obtained from assessment of traditional risk factors was obtained. CONCLUSION In patients with documented CAD, C-reactive protein and fibrinogen were predictive for future cardiovascular risk, but did not provide further information on top of that obtained from models including traditional risk factors. Our data emphasize the clinical importance of traditional risk factors in patients with CAD.
Silencing of XB130 Is Associated with Both the Prognosis and Chemosensitivity of Gastric Cancer

XB130 is a newly characterized adaptor protein that was reported to promote thyroid tumor growth, but its role in the progression of other kinds of cancer such as gastric cancer (GC) remains unknown. Accordingly, we investigated the association between XB130 expression and the prognosis of GC patients. The subjects were 411 patients with GC in stages I to IV. XB130 expression was examined in surgical specimens of GC. Kaplan-Meier analysis and the Cox proportional hazards model were used to assess the prognostic significance of XB130 for survival and recurrence. Moreover, GC cells stably transfected with XB130 short hairpin RNA were established to analyze the effect of XB130 on sensitivity of chemotherapy. The results show that both XB130 mRNA and protein expression were detectable in normal gastric tissues. The overall survival time of stage IV patients and the disease-free period after radical resection of GC in stage I–III patients were significantly shorter when immunohistochemical staining for XB130 was low than when staining was high (both p<0.05). XB130 expression also predicted tumor sensitivity to several chemotherapy agents. Viability of both XB130-silenced SGC7901 cells and wild-type cells was suppressed by 5-fluorouracil (5-FU), cisplatin, and irinotecan in a dose-dependent way, but cisplatin and irinotecan were more sensitive against sXB130-silenced GC cells and 5-FU showed higher sensitivity to wild-type cells. When treated by 5-FU, patients with high expression of XB130 tumors had a higher survival rate than those with low expression tumors. These findings indicate that reduced XB130 protein expression is a prognostic biomarker for shorter survival and a higher recurrence rate in patients with GC, as well as for the response to chemotherapy.