Miracle-dz/UniFAR-FTUs huggingface dataset:
‘New’ Scottish Gaelic speakers in Glasgow: A phonetic study of language revitalisation

Abstract This article analyses phonetic variation among young people who have learned a minority language in immersion schooling as part of revitalisation measures. Such speakers are increasingly referred to as ‘new speakers’ in an expanding body of literature. The variable phonetic features analysed are vowels, laterals, and intonation in the speech of new Gaelic speakers from Glasgow and the Isle of Lewis. Results support previous work suggesting that new speakers will sound different from ‘traditional speakers’. These results are discussed in terms of language contact, modes of acquisition in revitalisation situations, and the differing perceptions and ideologies surrounding how new speakers use Gaelic. The data also necessitate an examination of some of the assumptions in sociolinguistic models of change and their applicability to contexts of rapid social evolution. (New speakers, language revitalisation, minority languages, Scottish Gaelic, laterals, vowels, intonation)*
Progenitors of interstitial cells of cajal in the postnatal murine stomach.

BACKGROUND & AIMS Maintaining the integrity of networks of interstitial cells of Cajal (ICC) is essential to preserve orderly contractile activity and neuroregulation in the gastrointestinal tract and to restore these functions after tissue damage or surgeries. Maintenance of ICC requires insulin-dependent or insulin-like growth factor I (IGF-I)-dependent production of membrane-bound stem cell factor (SCF) and may involve regeneration from local progenitors. Our goal was to identify ICC precursors in postnatal murine gastric muscles. METHODS We used flow cytometry and immunohistochemistry to examine freshly dissected and cultured muscles for cells expressing CD34, an adhesion molecule expressed by stromal tumors; CD44, which occurs on mesenchymal stem cells; and receptors for SCF (Kit), insulin (Insr), and IGF-I (Igf1r). Slow waves were studied by intracellular recording. RESULTS In gastric muscles, we identified rare, Kit(low)CD44(+)CD34(+)Insr(+)Igf1r(+) cells resembling common embryonic precursors of ICC and smooth muscle. These putative progenitors were absent from organotypic cultures lacking mature ICC (Kit(+)CD44(+)CD34(-)Insr(-)Igf1r(-)) due to prolonged insulin/IGF-I deprivation but were rescued by IGF-I that also prevented ICC loss. Soluble SCF failed to prevent the loss of mature ICC but dramatically expanded the putative progenitors, which supported robust slow wave activity despite retaining an immature, Kit(+)CD44(+)CD34(+)Insr(+)Igf1r(+) phenotype. Differentiation of these cells into mature, network-forming ICC required IGF-I. Conversely, restoration of ICC networks by IGF-I after prolonged insulin and IGF-I deprivation required the survival of the presumed progenitors. CONCLUSIONS Kit(low)CD44(+)CD34(+)Insr(+)Igf1r(+) cells may be local progenitors for gastric ICC and stromal tumors. Loss of these cells may contribute to gastrointestinal dysmotilities.
The phosphoinositide‐3 kinase signaling is involved in neuroinflammation in hypertensive rats

It has been demonstrated that neuroinflammation is associated with cardiovascular dysfunction. The phosphoinositide‐3 kinase (PI3K) signaling in the rostral ventrolateral medulla (RVLM), a key region for sympathetic outflow, is upregulated and contributes to increased blood pressure (BP) and sympathetic outflow in hypertension. This study was designed to determine the role of the PI3K signaling in neuroinflammation in the RVLM of hypertension.
Population genetic structure of North American thinhorn sheep (Ovis dalli)

The thinhorn sheep (Ovis dalli ssp.) provides a rare example of a North American large mammal that occupies most of its native range and maintains close to ancestral population size. There are currently two recognized subspecies, Dall's sheep (O. d. dalli) and Stone's sheep (O. d. stonei), the validity of which remains uncertain. We investigated the spatial genetic structure of thinhorn sheep populations representing both subspecies by genotyping individuals (n = 919) from across the species range at 12 variable microsatellite loci. We found high levels of genetic diversity within (HE = 0.722) and significant genetic structure among the 24 sampled areas (FST = 0.160). Genetic distance measures and Bayesian clustering analyses revealed the presence of at least eight subpopulations that are delineated by mountain range topology. A strong overall pattern of isolation‐by‐distance is evident across the sampling range (r = 0.75, P < 0.001) suggesting limited dispersal and extensive philopatry. Partial Mantel tests of this relationship showed mountain range distinctions represent significant barriers to gene flow (P = 0.0001), supporting the Bayesian analyses. Genetic structure was more strongly pronounced in southern Yukon and Alaska than elsewhere. We also show evidence for genetic differences between the two currently recognized thinhorn subspecies.
Physical-Layer Authentication

Authentication is the process where claims of identity are verified. Most mechanisms of authentication (e.g., digital signatures and certificates) exist above the physical layer, though some (e.g., spread-spectrum communications) exist at the physical layer often with an additional cost in bandwidth. This paper introduces a general analysis and design framework for authentication at the physical layer where the authentication information is transmitted concurrently with the data. By superimposing a carefully designed secret modulation on the waveforms, authentication is added to the signal without requiring additional bandwidth, as do spread-spectrum methods. The authentication is designed to be stealthy to the uninformed user, robust to interference, and secure for identity verification. The tradeoffs between these three goals are identified and analyzed in block fading channels. The use of the authentication for channel estimation is also considered, and an improved bit-error rate is demonstrated for time-varying channels. Finally, simulation results are given that demonstrate the potential application of this authentication technique.
The Ly-1 B cell lineage.

INTRODUCTION The murine Ly-1 lymphocyte surface glycoprotein was defined initially with conventional antisera in cytotoxic assays. As such, it appeared to be expressed exclusively on helper T cells. Later, however, Fluorescence Acitivated Cell Sorter (FACS) analyses and sorting studies with monoclonal antibody reagents showed that all T cells express Ly-1, regardless of functional subclass° Furthermore, these studies2'3' showed that Ly-1 is expressed on several murine B cell tumors and introduced evidence suggesting that this glycoprotein may also expressed on a small proportion of normal murine splenic B cells4.5' Similar studies with human lymphocytes demonstrated the homologous (Leu-1) cell surface antigen on all normal T cells6), on some B cell tumors (particularly chronic lymphocytic leukemias) 7) and, as in the mouse, on a small proportion of apparently normal B cells"). Thus, a series of earlier findings foreshadowed contemporary evidence demonstrating Ly-1 and Leu-1, respectively, on subsets of murine and human B cells and showing further that Ly-1 marks functionally distinct B cells that play a major role in autoimmunity in the mouse. Here we summarize the physical and functional characteristics that distinguish Ly-1 B cells from the majority of splenic and lymph node B cells. We focus on data from cell transfer and antibody treatment studies, which locate Ly-1 B cells in a separate developmental lineage that branches off from the lymphocyte developmental lineage during prenatal or early neonatal life. We then consider various genetic defects that influence autoantibody production and Ly-1 B representation and, finally, we discuss potential homologies between Ly-1 B and B cells in other species and the possible role (s)that Ly-1 B cells may play as producers of *Department of Genetics, Stanford Universily,
LimitLESS directories: A scalable cache coherence scheme

Caches enhance the performance of multiprocessors by reducing network traffic and average memory access latency. However, cache-based systems must address the problem of cache coherence. We propose the LimitLESS directory protocol to solve this problem. The LimitLESS scheme uses a combination of hardware and software techniques to realize the performance of a full-map directory with the memory overhead of a limited directory. This protocol is supported by Alewife, a large-scale multiprocessor. We describe the architectural interfaces needed to implement the LimitLESS directory, and evaluate its performance through simulations of the Alewife machine.
Exploring the Impact of Assistive Technologies in the Classroom for Students with Disabilities

This analytical review explores the impact of assistive technology (AT) on academic achievement for students with physical, intellectual, and developmental disabilities in pre-K to 12 th -grade classrooms. Extant scholarly literature from 2010 to 2015 is examined in this analytical review. Findings indicate that when students with physical, intellectual, and developmental disabilities use AT such as iPads®, software, speech generators, electronic notebooks, and computer-assisted instruction, there was an increase in academic achievement (e.g. spelling or writing skills) and an increase in student engagement. AT may be effective for one student; however, it may not be effective for another student with the same disability. When making decisions about AT in the classroom, teachers must consider the unique, individual needs of students.
Exploration, Exploitation, and Growth Through New Product Development: The Moderating Effects of Firm Age and Environmental Adversity

This study investigates how firm age and environmental adversity influence exploration and exploitation and whether the balance between them increases new product development. We also examine if new product development in new and mature firms leads to equivalent growth rates. Empirical results obtained from a survey of small- and medium-sized technology-based manufacturing firms in Korea show that while relative exploration generally remains lower in mature firms than in new firms, it more rapidly increases in mature firms when they operate in adverse environments. Interestingly, our results show that mature firms achieve lower growth rates through new product development than new firms in adverse environments. These empirical findings advance our understanding of the age-dependent antecedents and consequences of new product development.
Large-scale image categorization with explicit data embedding

Kernel machines rely on an implicit mapping of the data such that non-linear classification in the original space corresponds to linear classification in the new space. As kernel machines are difficult to scale to large training sets, it has been proposed to perform an explicit mapping of the data and to learn directly linear classifiers in the new space. In this paper, we consider the problem of learning image categorizers on large image sets (e.g. > 100k images) using bag-of-visual-words (BOV) image representations and Support Vector Machine classifiers. We experiment with three approaches to BOV embedding: 1) kernel PCA (kPCA) [15], 2) a modified kPCA we propose for additive kernels and 3) random projections for shift-invariant kernels [14]. We report experiments on 3 datasets: Cal-tech101, VOC07 and ImageNet. An important conclusion is that simply square-rooting BOV vectors – which corresponds to an exact mapping for the Bhattacharyya kernel – already leads to large improvements, often quite close to the best results obtained with additive kernels. Another conclusion is that, although it is possible to go beyond additive kernels, the embedding comes at a much higher cost.
Social Anxiety Modulates Subliminal Affective Priming

Background It is well established that there is anxiety-related variation between observers in the very earliest, pre-attentive stage of visual processing of images such as emotionally expressive faces, often leading to enhanced attention to threat in a variety of disorders and traits. Whether there is also variation in early-stage affective (i.e. valenced) responses resulting from such images, however, is not yet known. The present study used the subliminal affective priming paradigm to investigate whether people varying in trait social anxiety also differ in their affective responses to very briefly presented, emotionally expressive face images. Methodology/Principal Findings Participants (n = 67) completed a subliminal affective priming task, in which briefly presented and smiling, neutral and angry faces were shown for 10 ms durations (below objective and subjective thresholds for visual discrimination), and immediately followed by a randomly selected Chinese character mask (2000 ms). Ratings of participants' liking for each Chinese character indicated the degree of valenced affective response made to the unseen emotive images. Participants' ratings of their liking for the Chinese characters were significantly influenced by the type of face image preceding them, with smiling faces generating more positive ratings than neutral and angry ones (F(2,128) = 3.107, p<0.05). Self-reported social anxiety was positively correlated with ratings of smiling relative to neutral-face primed characters (Pearson's r = .323, p<0.01). Individual variation in self-reported mood awareness was not associated with ratings. Conclusions Trait social anxiety is associated with individual variation in affective responding, even in response to the earliest, pre-attentive stage of visual image processing. However, the fact that these priming effects are limited to smiling and not angry (i.e. threatening) images leads us to propose that the pre-attentive processes involved in generating the subliminal affective priming effect may be different from those that generate attentional biases in anxious individuals.
In vitro model of attachment of Giardia intestinalis trophozoites to IEC-6 cells, an intestinal cell line

Attachment of giardias to intestinal cells has been difficult to study because of a lack of a convenient in vitro model. We developed an assay for attachment of radiolabeled trophozoites to IEC-6 cells that can be done in microtiter trays. Attachment was confirmed by scanning and transmission electron microscopy. Trophozoites remained attached to the IEC-6 cells for 24 h with little evidence of damage to the IEC-6 cells. Preincubation of trophozoites with cytochalasins A, B, and D reduced attachment to approximately 20% of that of controls, whereas colchicine had no effect. Chelation of divalent cations with EDTA and EGTA [ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid] reduced attachment to 24 and 26% of control values, respectively, and incubation at 4 degrees C reduced attachment to 7% of the value for controls incubated at 37 degrees C. Glutaraldehyde fixation of trophozoites or IEC-6 cells resulted in significantly diminished attachment to the live substrate (17 and 40% of control values, respectively). Coincubation of IEC-6 cells and trophozoites on a rotary shaker resulted in detachment of 40% of trophozoites, but EDTA, EGTA, glutaraldehyde fixation of trophozoites, and low temperature diminished attachment markedly and significantly. Similar results were obtained in selected experiments with three strains of giardia.
A Novel MECP2 Change in an Indian Boy With Variant Rett Phenotype and Congenital Blindness: Implications for Genetic Counseling and Prenatal Diagnosis

Mutations in MECP2 gene are the primary cause of Rett syndrome, a neurodevelopmental disorder that primarily affects girls, and affect 90% to 95% patients with classical Rett syndrome. MECP2 mutations, once thought to be lethal in males, now present a broad spectrum of clinical manifestations in males. This article reports a family with a 9-year-old boy with Rett-like phenotype and congenital blindness, who inherited a novel MECP2 variant (p.P430S) from his asymptomatic mother. The variant was also identified in the asymptomatic maternal grandfather and maternal aunts of the proband, ruling out the possibility that the p.P430S was involved in the phenotype. Findings of the study suggest that a careful evaluation of the pathogenic nature of MECP2 variants identified in males be conducted before proposing genetic counseling or prenatal diagnosis to the family and that the interference of other factors like modifier genes, environment, epigenetics, and mosaicism be taken into account.
Retrospective Study of Hemoparasites in Cattle in Southern Italy by Reverse Line Blot Hybridization

ABSTRACT Tick-borne diseases are widespread in tropical and temperate regions and are responsible for important economic losses in those areas. In order to assess the presence and prevalence of various pathogens in southern Italy, we retrospectively analyzed cattle blood samples collected for a previous study in 2000 using reverse line blot (RLB) hybridization. The study had been carried out in three regions of southern Italy on 1,500 randomly selected and apparently healthy adult cattle. RLB showed that 43.7% of the cattle were positive for nine different species of hemoparasites with either a single infection or a mixed infection. Theileria buffeli was the most common species found, being present in 27.3% of the animals, followed by Anaplasma marginale in 18.1%, Anaplasma centrale in 13.8%, Babesia bigemina and Anaplasma bovis in 4.2%, Anaplasma phagocytophilum in 1.7%, Babesia bovis in 1.6%, Babesia major in 0.2% and Babesia divergens in 0.1%. Complete blood counts showed different degrees of anemia in 363 animals (24.2%) and of these, 169 were RLB-positive for at least one pathogen. Among the ticks that were collected from the cattle, the following species were identified: Rhipicephalus bursa, Ixodes ricinus, Hyalomma marginatum, Boophilus annulatus, Dermacentor marginatus and Haemaphysalis (sulcata, parva, inermis and punctata). The results obtained confirmed the spread of endemic tick-borne pathogens in the regions studied.
Role models, school improvement and the ‘gender gap’—do men bring out the best in boys and women the best in girls?1

A number of countries are running role model recruitment drives under the assumption that like is good for like: ethnic minority teachers should teach ethnic minority children, women should teach girls, and so on. The empirical basis for this would appear to be case study and personal reflection. This article will examine quantitative data to test the hypothesis that male teachers produce more positive attitudes amongst boys and female teachers amongst girls. Using data from the Performance Indicators in Primary Schools (PIPS) Project, information from 413 separate classes for 11 year-olds (in England) was examined. One hundred and thirteen were taught by males and 300 by females. All the pupils completed questionnaires that were designed to measure attitude to school, reading, mathematics and science. In addition, background data on those pupils were collected, including cognitive measures, attainment scores, ability measures and home background measures. The data were examined to look at attitudes using multilevel models controlling for background factors. The analysis concentrated on interaction effects between the gender of the teacher and the gender of the pupil and the results gave little support for those who advocate recruitment drives with role models in mind.
PHYSICOCHEMICAL, BIOCHEMICAL, TEXTURAL AND SENSORY PROPERTIES OF TELLI CHEESE - A TRADITIONAL TURKISH CHEESE MADE FROM COW MILK

KESENKAS, H. , N. DINKCI, K. SECKIN, O. GURSOY and O. KINIK, 2012. Physicochemical, biochemical, textural and sensory properties of telli cheese - a traditional Turkish cheese made from cow milk. Bulg. J. Agric. Sci., 18: 763-770 Telli (threaded) cheese is a hard cheese variety produced in the Eastern Black Sea Region of Turkey. Physicochemical, biochemical, textural and sensory properties of cow milk Telli cheese samples were investigated during 90 days of storage. Cheese samples were characterized with their high total solids (54.44%), fat (25.25%) and protein (25.14%) contents. Lactic acid was the first abundant organic acid in cheeses. The most abundant saturated fatty acids were palmitic, stearic and myristic acids while the oleic acid was found to have the highest level among the unsaturated fatty acids. Lipolysis and proteolysis of samples were increased throughout storage.
Comparative study of continuous extrapleural intercostal nerve block and lumbar epidural morphine in post-thoracotomy pain.

OBJECTIVES To compare the efficacy of continuous extrapleural intercostal nerve block with bupivacaine 0.5% in 1:200,000 epinephrine and continuous lumbar epidural block with morphine in controlling post-thoracotomy pain and to measure serum bupivacaine concentrations during extrapleural infusion. DESIGN A prospective, randomized, controlled trial. SETTING St. Joseph's Hospital, Hamilton, Ont. , a tertiary care teaching centre. PATIENTS Sixty-one patients booked for elective thoracotomy were randomized by scaled envelope to two groups. INTERVENTIONS Group A received a continuous extrapleural intercostal nerve block with bupivacaine 0.5% in 1:200,000 epinephrine as a bolus of 0.3 mL/kg followed by an infusion of 0.1 mL/kg every hour for 72 hours. Group B received a continuous lumbar epidural block with morphine as a bolus of 70 g/kg followed by an infusion of 7 g/kg every hour for 72 hours. MAIN OUTCOME MEASURES Pain was assessed by a linear visual analogue scale (VAS) pain score. The cumulative amount of "rescue" intravenous morphine used, and serum bupivacaine concentrations were measured as secondary outcomes. RESULTS Pain control was the same in both groups as assessed by linear VAS score (p = 0.33). The cumulative dose of intravenous morphine for supplemental analgesia was statistically significant between the groups: group A patients used more morphine than group B (p < 0.05). Accumulation of serum bupivacaine was present with no clinical toxicity. CONCLUSIONS There is no significant difference in the degree of post-thoracotomy pain control measured by the VAS score when analgesia is provided by continuous extrapleural intercostal nerve block with bupivacaine 0.5% in 1:200,000 epinephrine or lumbar epidural block with morphine. Larger amounts of rescue analgesia were used by patients in the continuous extrapleural group with bupivacaine than those in the continuous lumbar epidural block with morphine. Serum bupivacaine concentrations rise without clinical toxicity.