Miracle-dz/UniFAR-FTUs huggingface dataset:
The Instructional Use and Teaching Preparation of Graduate Students in U.S. Ph.D.-Granting Economics Departments

Graduate students are employed extensively in the teaching of economics at the undergraduate level, but little is known about how they are used for instruction and how they are prepared for their teaching duties. To investigate this topic, we prepared a survey and sent it to the chairs of all 100 Ph.D.-granting economics departments. The survey was designed to elicit information on (i) the size of Ph.D. economics programs and the uses of graduate students for undergraduate instruction, (ii) the provision of credit and noncredit courses in teaching for economics graduate student instructors, (iii) teaching programs for international graduate students serving as economics instructors, and (iv) the uses of teaching evaluation for graduate-student instructors in economics. Two members of the AEA Committee on Economic Education reviewed initial drafts of the survey. Several economists with extensive experience in survey work and the teaching preparation of economics graduate students also provided constructive criticism. It underwent five revisions before it was sent to department chairs via regular mail in mid-August 2002. We received 85 of 100 surveys mailed. This high response rate was achieved through two follow-up mailings to nonresponding chairs, and by assuring all respondents that only the aggregate findings would be reported. The response rate was also high across departments, regardless of research ranking (see Thursby, 2000). It was 88 percent for the top third of departments, 97 percent for the middle third, and 71 percent for the lowest third. The higher response rate for the middle third is probably because more graduate students teach at these mostly large, public universities. The lower response rate for the bottom-third departments reflects some difficulty in contacting their chairs; but it might also indicate less activity to report.
Sensory Coding and Sensitivity to Local Estrogens Shift during Critical Period Milestones in the Auditory Cortex of Male Songbirds

Visual Abstract Abstract Vocal learning occurs during an experience-dependent, age-limited critical period early in development. In songbirds, vocal learning begins when presinging birds acquire an auditory memory of their tutor’s song (sensory phase) followed by the onset of vocal production and refinement (sensorimotor phase). Hearing is necessary throughout the vocal learning critical period. One key brain area for songbird auditory processing is the caudomedial nidopallium (NCM), a telencephalic region analogous to mammalian auditory cortex. Despite NCM’s established role in auditory processing, it is unclear how the response properties of NCM neurons may shift across development. Moreover, communication processing in NCM is rapidly enhanced by local 17β-estradiol (E2) administration in adult songbirds; however, the function of dynamically fluctuating E2 in NCM during development is unknown. We collected bilateral extracellular recordings in NCM coupled with reverse microdialysis delivery in juvenile male zebra finches (Taeniopygia guttata) across the vocal learning critical period. We found that auditory-evoked activity and coding accuracy were substantially higher in the NCM of sensory-aged animals compared to sensorimotor-aged animals. Further, we observed both age-dependent and lateralized effects of local E2 administration on sensory processing. In sensory-aged subjects, E2 decreased auditory responsiveness across both hemispheres; however, a similar trend was observed in age-matched control subjects. In sensorimotor-aged subjects, E2 dampened auditory responsiveness in left NCM but enhanced auditory responsiveness in right NCM. Our results reveal an age-dependent physiological shift in auditory processing and lateralized E2 sensitivity that each precisely track a key neural “switch point” from purely sensory (pre-singing) to sensorimotor (singing) in developing songbirds.
Quantifying the Effects of Historical Land Cover Conversion Uncertainty on Global Carbon and Climate Estimates

Previous studies have examined land use change as a driver of global change, but the translation of land use change into land cover conversion has been largely unconstrained. Here we quantify the effects of land cover conversion uncertainty on the global carbon and climate system using the integrated Earth System Model. Our experiments use identical land use change data and vary land cover conversions to quantify associated uncertainty in carbon and climate estimates. Land cover conversion uncertainty is large, constitutes a 5 ppmv range in estimated atmospheric CO2 in 2004, and generates carbon uncertainty that is equivalent to 80% of the net effects of CO2 and climate and 124% of the effects of nitrogen deposition during 1850–2004. Additionally, land cover uncertainty generates differences in local surface temperature of over 1°C. We conclude that future studies addressing land use, carbon, and climate need to constrain and reduce land cover conversion uncertainties.
Psychophysiological and Modulatory Interactions in Neuroimaging

In this paper we introduce the idea of explaining responses, in one cortical area, in terms of an interaction between the influence of another area and some experimental (sensory or task-related) parameter. We refer to these effects as psychophysiological interactions and relate them to interactions based solely on experimental factors (i.e., psychological interactions), in factorial designs, and interactions among neurophysiological measurements (i.e., physiological interactions). We have framed psychophysiological interactions in terms of functional integration by noting that the degree to which the activity in one area can be predicted, on the basis of activity in another, corresponds to the contribution of the second to the first, where this contribution can be related to effective connectivity. A psychophysiological interaction means that the contribution of one area to another changes significantly with the experimental or psychological context. Alternatively these interactions can be thought of as a contribution-dependent change in regional responses to an experimental or psychological factor. In other words the contribution can be thought of as modulating the responses elicited by a particular stimulus or psychological process. The potential importance of this approach lies in (i) conferring a degree of functional specificity on this aspect of effective connectivity and (ii) providing a model of modulation, where the contribution from a distal area can be considered to modulate responses to the psychological or stimulus-specific factor defining the interaction. Although distinct in neurobiological terms, these are equivalent perspectives on the same underlying interaction. We illustrate these points using a functional magnetic resonance imaging study of attention to visual motion and a position emission tomography study of visual priming. We focus on interactions among extrastriate, inferotemporal, and posterior parietal regions during visual processing, under different attentional and perceptual conditions.
Circuit Complexity, Proof Complexity, and Polynomial Identity Testing

We introduce a new and natural algebraic proof system, which has tight connections to (algebraic) circuit complexity. In particular, we show that any super-polynomial lower bound on any Boolean tautology in our proof system implies that the permanent does not have polynomial-size algebraic circuits (VNP≠VP). As a corollary, super-polynomial lower bounds on the number of lines in Polynomial Calculus proofs (as opposed to the usual measure of number of monomials) imply the Permanent versus Determinant Conjecture. Note that, prior to our work, there was no proof system for which lower bounds on an arbitrary tautology implied any computational lower bound. Our proof system helps clarify the relationships between previous algebraic proof systems, and begins to shed light on why proof complexity lower bounds for various proof systems have been so much harder than lower bounds on the corresponding circuit classes. In doing so, we highlight the importance of polynomial identity testing (PIT) for understanding proof complexity.
Behind the Scenes of Online Attacks: an Analysis of Exploitation Behaviors on the Web

Web attacks are nowadays one of the major threats on the Internet, and several studies have analyzed them, providing details on how they are performed and how they spread. However, no study seems to have sufficiently analyzed the typical behavior of an attacker after a website has been compromised. This paper presents the design, implementation, and deployment of a network of 500 fully functional honeypot websites, hosting a range of different services, whose aim is to attract attackers and collect information on what they do during and after their attacks. In 100 days of experiments, our system automatically collected, normalized, and clustered over 85,000 files that were created during approximately 6,000 attacks. Labeling the clusters allowed us to draw a general picture of the attack landscape, identifying the behavior behind each action performed both during and after the exploitation of a web application.
Within, but not between hands interactions in vibrotactile detection thresholds reflect somatosensory receptive field organization

Detection of a tactile stimulus on one finger is impaired when a concurrent stimulus (masker) is presented on an additional finger of the same or the opposite hand. This phenomenon is known to be finger-specific at the within-hand level. However, whether this specificity is also maintained at the between hand level is not known. In four experiments, we addressed this issue by combining a Bayesian adaptive staircase procedure quick estimation of threshold (QUEST) with a two-interval forced choice (2IFC) design in order to establish threshold for detecting 200 ms, 100 Hz sinusoidal vibrations applied to the index or little fingertip of either hand (targets). We systematically varied the masker finger (index, middle, ring, or little finger of either hand), while controlling the spatial location of the target and masker stimuli. Detection thresholds varied consistently as a function of the masker finger when the latter was on the same hand (Experiments 1 and 2), but not when on different hands (Experiments 3 and 4). Within the hand, detection thresholds increased for masker fingers closest to the target finger (i.e., middle > ring when the target was index). Between the hands, detection thresholds were higher only when the masker was present on any finger as compared to when the target was presented in isolation. The within hand effect of masker finger is consistent with the segregation of different fingers at the early stages of somatosensory processing, from the periphery to the primary somatosensory cortex (SI). We propose that detection is finger-specific and reflects the organization of somatosensory receptive fields in SI within, but not between the hands.
Kinetics of Human B Cell Behavior and Amplification of Proliferative Responses following Stimulation with IL-211

Although recent studies indicated that IL-21 is an important regulator of human B cell activation, detailed comparison of the effects of IL-21 on distinct B cell subsets have not been performed. Our studies revealed that IL-21R is expressed by naive and germinal center B cells, but not memory or plasma cells. IL-21R was increased on naive and memory B cells following in vitro activation. Investigation into the kinetics and magnitude of responses of human B cells to IL-21 revealed that IL-21 potently augmented proliferation of CD40L-stimulated neonatal, splenic naive, and memory and tonsil germinal center B cells. This response exceeded that induced by IL-4, IL-10, and IL-13, cytokines that also induce B cell proliferation. Remarkably, CD40L/IL-21-stimulated naive B cells underwent the same number of divisions as memory cells and exhibited a greater enhancement in their response compared with CD40L alone than memory B cells. Therefore, IL-21 is a powerful growth factor for naive B cells. This may result from the higher expression of IL-21R on naive, compared with memory, B cells. Stimulation of human B cells with CD40L/IL-21 also induced IL-10 production and activation of STAT3. We propose that IL-21 may have therapeutic application in conditions of immunodeficiency where it could expand naive B cells, the predominant B cell subset in such patients. Conversely, because IL-21 is increased in murine models of lupus, dysregulated IL-21 production may contribute to perturbed B cell homeostasis observed in systemic lupus erythematosus. Thus, antagonizing IL-21 may be a novel strategy for treating Ab-mediated autoimmune diseases.
Albumin Adducts of Electrophilic Benzene Metabolites in Benzene-Exposed and Control Workers

Background Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts. Objectives The main purpose of this study was to characterize relationships between levels of albumin adducts of these electrophiles in blood and the corresponding benzene exposures in benzene-exposed and control workers, after adjusting for important covariates. Because second blood samples were obtained from a subset of exposed workers, we also desired to estimate within-person and between-person variance components for the three adducts. Methods We measured albumin adducts and benzene exposures in 250 benzene-exposed workers (exposure range, 0.26–54.5 ppm) and 140 control workers (exposure range < 0.01–0.53 ppm) from Tianjin, China. Separate multiple linear regression models were fitted to the logged adduct levels for workers exposed to benzene < 1 ppm and ≥ 1 ppm. Mixed-effects models were used to estimate within-person and between-person variance components of adduct levels. Results We observed nonlinear (hockey-stick shaped) exposure–adduct relationships in log-scale, with inflection points between about 0.5 and 5 ppm. These inflection points represent air concentrations at which benzene contributed marginally to background adducts derived from smoking and from dietary and endogenous sources. Adduct levels were significantly affected by the blood-collection medium (serum or plasma containing either heparin or EDTA), smoking, age, and body mass index. When model predictions of adduct levels were plotted versus benzene exposure ≥ 1 ppm, we observed marked downward concavity, particularly for adducts of the benzoquinones. The between-person variance component of adduct levels increased in the order 1,2-BQ < 1,4-BQ < BO, whereas the within-person variance components of the three adducts followed the reverse order. Conclusions Although albumin adducts of BO and the benzoquinones reflect exposures to benzene ≥ 1 ppm, they would not be useful biomarkers of exposure at ambient levels of benzene, which tend to be < 0.01 ppm, or in those working populations where exposures are consistently < 1 ppm. The concavity of exposure–adduct relationships is consistent with saturable metabolism of benzene at air concentrations > 1 ppm. The surprisingly large effect of the blood-collection medium on adduct levels, particularly those of the benzoquinones, should be further investigated.
Exploring the Iterated Update Universe

In this paper we investigate the properties of the logical system developped by Baltag, Moss and Solecki [BMS], which is a product of quite lively line of research on update logics. We build on the idea of looking at update logics as dynamical systems, where the issue of asymptotic behavior is paramount. We first give a characterization of action equivalence relation holding between action models (epistemic programs) effecting the same update in terms of acton bisimulation, which is dual to, and generalizes traditional bisimulation. Then we prove "conservative" properties of update with factual action models (models with only propositional prerequisite formulas), and characterize in terms of pebble game the class of frames such that iterated update with factual action model built over them gives rise only to finite update orbits, finite evolution of epistemic states. Finally, after giving some basic insights into "dissipative" nature of update with general action models, we show the distinctive stabilizing nature of epistemically ordered multi-S5 action models action models in which agents can be ordered in terms of how much they know.
Clinical Interventions in Aging Dovepress Effect of 6 Months of Whole Body Vibration on Lumbar Spine Bone Density in Postmenopausal Women: a Randomized Controlled Trial

Background: The issue of osteoporosis-induced fractures has attracted the world's attention. Postmenopausal women are particularly at risk for this type of fracture. The nonmedicinal intervention for postmenopausal women is mainly exercise. Whole body vibration (WBV) is a simple and convenient exercise. There have been some studies investigating the effect of WBV on osteoporosis; however, the intervention models and results are different. This study mainly investigated the effect of high-frequency and high-magnitude WBV on the bone mineral density (BMD) of the lumbar spine in postmenopausal women. Methods: This study randomized 28 postmenopausal women into either the WBV group or the control group for a 6-month trial. The WBV group received an intervention of high-frequency (30 Hz) and high-magnitude (3.2 g) WBV in a natural full-standing posture for 5 minutes, three times per week, at a sports center. Dual-energy X-ray absorptiometry was used to measure the lumbar BMD of the two groups before and after the intervention. Results: Six months later, the BMD of the WBV group had significantly increased by 2.032% (P=0.047), while that of the control group had decreased by 0.046% (P=0.188). The comparison between the two groups showed that the BMD of the WBV group had increased significantly (P=0.016). Conclusion: This study found that 6 months of high-frequency and high-magnitude WBV yielded significant benefits to the BMD of the lumbar spine in postmenopausal women, and could therefore be provided as an alternative exercise.
How Much Can We Gain from Supervised Word Alignment?

Word alignment is a central problem in statistical machine translation (SMT). In recent years, supervised alignment algorithms, which improve alignment accuracy by mimicking human alignment, have attracted a great deal of attention. The objective of this work is to explore the performance limit of supervised alignment under the current SMT paradigm. Our experiments used a manually aligned Chinese-English corpus with 280K words recently released by the Linguistic Data Consortium (LDC). We treated the human alignment as the oracle of supervised alignment. The result is surprising: the gain of human alignment over a state of the art unsuper-vised method (GIZA++) is less than 1 point in BLEU. Furthermore, we showed the benefit of improved alignment becomes smaller with more training data, implying the above limit also holds for large training conditions.
Assessing the use of BreatheSmart® mobile technology in adult patients with asthma: a remote observational study

Introduction Non-adherence to asthma daily controller medications is a common problem, reported to be responsible for 60% of asthma-related hospitalisations. The mean level of adherence for asthma medications is estimated to be as low as 22%. Therefore, objective measurements of adherence to medicine are necessary. This virtual observational study is designed to measure the usability of an electronic monitoring device platform that measures adherence. Understanding how patients use the BreatheSmart mobile technology at home is essential to assess its feasibility as a solution to improve medication adherence. We anticipate this approach can be applied to real-world environments as a cost-effective solution to improve medication adherence. Methods and analysis This is a virtual 6-month observational study of 100 adults (≥18 years) with an asthma diagnosis, using inhaled corticosteroids for at least 3 months. Participants will be recruited in the USA through ad placements online. All participants receive wireless Bluetooth-enabled inhaler sensors that track medication usage and an mSpirometerTM capable of clinical-grade lung function measurements, and download the BreatheSmart mobile application that transmits data to a secure server. All analyses are based on an intention-to-treat. Usability is assessed by patient questionnaires and question sessions. Simple paired t-test is used to assess significant change in Asthma Control Test score, quality of life (EuroQol-5D questionnaire) and lung function. Ethics and dissemination No ethical or safety concerns pertain to the collection of these data. Results of this research are planned to be published as soon as available. Trial registration number NCT03103880.
Possible El Niño–Southern Oscillation-related lacustrine facies developed in southern Lake Poyang during the late Holocene: Evidence from spore-pollen records

In order to explore the impacts of past climate changes on the origin and evolution of Lake Poyang, the biggest freshwater lake in China, eight periods of palaeoenvironmental changes were constructed to depict the history of climate change over the past 3500 years based on the palynological records and carbon isotopic excursions. The climate regime was associated with the presence of a deciduous and evergreen broad-leaved forest/a mixed needle broad-leaved forest and strong/weak solar variability. Palaeohydrology change reconstructed by the percentage of aquatics and stable carbon isotopes demonstrated that the wet episode was associated with the developed lacustrine facies and enhanced El Niño–Southern Oscillation (ENSO) activities. The presence of the united open lake (Lake Poyang) during 2000–1200 cal. a BP was linked to a long wet period caused by the strong ENSO activities. At the decadal-centennial timescales, climate changes together with the ENSO activities might have played a great role on the regional hydrological condition and sedimentary evolution in southern Lake Poyang. The correlations of the palaeotemperature and palaeohydrology with the multi-proxy data from the Northern Hemisphere all suggest that palaeotemperature change with the monsoon intensity is linked to the solar variations, but palaeohydrology change has a striking consistency with the ENSO activities. The distinct hydrothermal diversification (warm-wet, warm-dry, cold-wet, cold-dry) revealed by the palaeotemperature and palaeohydrology changes will provide important clues about the origin and evolution of Lake Poyang in the Holocene and a better understanding of the interactions between solar radiation, ENSO activity and lake deposition in the middle Yangtze River Valley.
Parsing Clinical Finnish: Experiments with Rule-Based and Statistical Dependency Parsers

In this paper, we present a new syntactically annotated corpus consisting of daily notes from an intensive care unit in a Finnish hospital. Using the corpus, we perform experiments with both rule-based and statistical parsers. We apply an existing rule-based parser specifically developed for this clinical language and create a set of conversion rules for transforming the constituency scheme of this parser into the dependency scheme of the corpus. The statistical parser is induced from the corpus using the MaltParser system. We find that even with a modestly-sized corpus, the statistical parser achieves results comparable to those previously reported on a number of languages using considerably larger corpora. The accurate constituency-to-dependency conversion improves the applicability of the rule-based parser by inferring grammatical roles, thus deepening its analyses.