Miracle-dz/UniFAR-FTUs huggingface dataset:
Sensory gating of an embryonic zebrafish interneuron during spontaneous motor behaviors

In all but the simplest monosynaptic reflex arcs, sensory stimuli are encoded by sensory neurons that transmit a signal via sensory interneurons to downstream partners in order to elicit a response. In the embryonic zebrafish (Danio rerio), cutaneous Rohon-Beard (RB) sensory neurons fire in response to mechanical stimuli and excite downstream glutamatergic commissural primary ascending (CoPA) interneurons to produce a flexion response contralateral to the site of stimulus. In the absence of sensory stimuli, zebrafish spinal locomotor circuits are spontaneously active during development due to pacemaker activity resulting in repetitive coiling of the trunk. Self-generated movement must therefore be distinguishable from external stimuli in order to ensure the appropriate activation of touch reflexes. Here, we recorded from CoPAs during spontaneous and evoked fictive motor behaviors in order to examine how responses to self-movement are gated in sensory interneurons. During spontaneous coiling, CoPAs received glycinergic inputs coincident with contralateral flexions that shunted firing for the duration of the coiling event. Shunting inactivation of CoPAs was caused by a slowly deactivating chloride conductance that resulted in lowered membrane resistance and increased action potential threshold. During spontaneous burst swimming, which develops later, CoPAs received glycinergic inputs that arrived in phase with excitation to ipsilateral motoneurons and provided persistent shunting. During a touch stimulus, short latency glutamatergic inputs produced cationic currents through AMPA receptors that drove a single, large amplitude action potential in the CoPA before shunting inhibition began, providing a brief window for the activation of downstream neurons. We compared the properties of CoPAs to those of other spinal neurons and propose that glycinergic signaling onto CoPAs acts as a corollary discharge signal for reflex inhibition during movement.
Facing Human Capital Challenges of the 21st Century: Education and Labor Market Initiatives in Lebanon, Oman, Qatar, and the United Arab Emirates

This title describes the education and labor market initiatives implemented or under way in four countries in the Arab region - Lebanon, Oman, Qatar, and the United Arab Emirates - to address the human resource issues they each face as they prepare their countries for a place in the 21st century global economy. Together, these countries highlight the variety of challenges faced by countries in the region and responses to those challenges.
Shock compression of molten silicate: Results for a model basaltic composition

A technique has been developed for measurement of the shock wave, pressure-density equation of state of molten silicates initially at temperatures of up to ∼2000 K. A 40-mm propellant gun apparatus accelerates metal flyer plates to speeds of up to 2.5 km s^(−1); these flyer plates are capable of driving shock waves with amplitudes of 35–40 GPa (350–400 kbar) into molten silicate samples. Modifications to the standard equation of state experiments that are described here include design of a molybdenum sample container for the molten silicate; use of a 10-kW radio frequency induction heater to melt the sample prior to impact; implementation of shuttering systems to protect the optical system and prevent preexposure of the film in the rotating-mirror, continuously writing, streak camera; and reduction of Hugoniot data taking into account the effect of the sample capsule. Data for a model basaltic liquid (36 mol % anorthite, 64 mol % diopside) at an initial temperature of 1673 K and initial density of 2.61 Mg m^(−3), yield a shock velocity-particle velocity (U_(S)-U_(P)) relation given by U_S = 3.06 + 1.36 UP km s^(−1) up to values of U_P = 1.7 km s^(−1). The zero-pressure, bulk sound speed is in good agreement with ultrasonic measurements. The best fit Birch-Murnaghan equation of state for this model basaltic liquid is K_(0S) = 24.2 GPa and K′ = 4.85 based on Hugoniot points at low pressures (<25 GPa). Within the resolution of our data set, density increases smoothly with pressure over the 0–25 GPa pressure range, suggesting that structural rearrangements take place gradually in response to pressure in this pressure interval. At high pressures (≳ 25 GPa) the Hugoniot data suggest that the liquid stiffens considerably. This may indicate that the gradual structural changes characteristic of the lower-pressure regime, such as changes of Al3+ and Si4+ coordination by oxygen from fourfold to sixfold, are essentially complete by ∼25 GPa. These high-pressure Hugoniot data are fit by US = 0.85 + 2.63 Up km s^(−1). The high-pressure regime is similar to that obtained in initially solid silicates upon shock compression. Shock temperature calculations yield values of 2400–2600 K at 25 GPa, and the states achieved are believed to lie metastably in the liquid field.
Identification of recurrence-related serum microRNAs in hepatocellular carcinoma following hepatectomy

Hepatocellular carcinoma (HCC) is one of the most deadly tumors. Prognosis of patients with HCC is generally poor due to the high recurrence rate. In the present study, TaqMan Real-time PCR microRNA Array was used to identify differentially expressed miRNAs from 10 tumor tissue samples (5 from recurrence group vs. 5 from non-recurrence group) and the matched serum samples. Four differentially expressed miRNAs (miR-486–5p, miR-422a, miR-125b and miR-139–5p) were further quantified in 20 tumor tissues and 116 HCC patients' serum before they received hepatectomy. Univariate analysis revealed that miR-486–5p, miR-422a and miR-125b were significantly associated with patients' relapse free survival (RFS). Multivariate analysis demonstrated that miR-486–5p, AFP and microvascular invasion (MVI) were the independent prognostic factors associated with RFS in this cohort (p = 0.000, 0.043, 0.000, respectively). Besides, the expression levels of miR-486–5p were positively correlated in tumor tissues and the paired serum samples, so was miR-422a. The probability of the prognostic accuracy of miR-486–5p in predicting postoperative recurrence of HCC within the first year was 76.79% (65.38% specificity and 81.58% sensitivity), which was almost equal to the classifier established by combination of AFP and MVI (75.98% probability, 63.13% specificity and 85.90% sensitivity). Furthermore, the combination of AFP, MVI and miR-486–5p yielded a ROC curve area of 88.02% (69.20% specificity and 92.10% sensitivity). Our study was the first to identify that serum miR-486–5p could be used to stratify the patients with higher recurrence risk before hepatic resection and potentially guide more effective surveillance strategies for them.
MRSA in Africa: Filling the Global Map of Antimicrobial Resistance

We sought to assess the prevalence of methicillin-resistance among Staphylococcus aureus isolates in Africa. We included articles published in 2005 or later reporting for the prevalence of MRSA among S. aureus clinical isolates. Thirty-two studies were included. In Tunisia, the prevalence of MRSA increased from 16% to 41% between 2002–2007, while in Libya it was 31% in 2007. In South Africa, the prevalence decreased from 36% in 2006 to 24% during 2007–2011. In Botswana, the prevalence varied from 23–44% between 2000–2007. In Algeria and Egypt, the prevalence was 45% and 52% between 2003–2005, respectively. In Nigeria, the prevalence was greater in the northern than the southern part. In Ethiopia and the Ivory Coast, the prevalence was 55% and 39%, respectively. The prevalence of MRSA was lower than 50% in most of the African countries, although it appears to have risen since 2000 in many African countries, except for South Africa.
Effect of serum lipoprotein(a) on estimation of low-density lipoprotein cholesterol by the Friedewald formula.

The calculation of serum low-density lipoprotein cholesterol (LDL-C) by the Friedewald formula does not account for the cholesterol associated with lipoprotein(a) [Lp(a)]. To quantify the contribution of Lp(a) cholesterol to total serum cholesterol, we measured concentrations of serum Lp(a) by an ELISA and concentrations of other serum lipids and lipoproteins by standard assays in 23 normolipemic women, ages 50-60 years. In measuring serum high-density lipoprotein we found that polyethylene glycol 6000 precipitated > 99.8% of all Lp(a). When serum Lp(a) concentrations were < or = 300 mg/L, 301-600 mg/L, and > 600 mg/L, the uncorrected serum LDL-C was overestimated, respectively, by a mean of 4.1% (n = 7), 8.5% (n = 8), and 21.4% (n = 8). Serum Lp(a) concentrations were positively correlated with percentage overestimation (P < 0.001), but were not correlated with either corrected or uncorrected serum LDL-C. We conclude that the Friedewald formula should be modified to take into account the contribution of Lp(a) cholesterol to total serum cholesterol.
Traditional Chinese Medicine Induced Liver Injury

Traditional Chinese Medicine (TCM) is popular around the world and encompasses many different practices with particular emphasis on herbal TCM. Using the PubMed database, a literature search was undertaken to assess the extent herbal TCM products exert rare hepatotoxicity. Analysis of reported cases revealed numerous specified herbal TCM products with potential hepatotoxicity. Among these were An Shu Ling, Bai Fang, Bai Xian Pi, Ban Tu Wan, Bo He, Bo Ye Qing Niu Dan, Bofu Tsu Sho San, Boh Gol Zhee, Cang Er Zi, Chai Hu, Chaso, Chi R Yun, Chuan Lian Zi, Ci Wu Jia, Da Chai Hu Tang, Da Huang, Du Huo, Gan Cao, Ge Gen, Ho Shou Wu, Hu Bohe You, Hu Zhang, Huang Qin, Huang Yao Zi, Hwang Geun Cho, Ji Gu Cao, Ji Ji, Ji Xue Cao, Jiguja, Jin Bu Huan, Jue Ming Zi, Kamishoyosan, Kudzu, Lei Gong Teng, Long Dan Xie Gan Tang, Lu Cha, Ma Huang, Mao Guo Tian Jie Cai, Onshido, Polygonum multiflorum, Qian Li Guang, Ren Shen, Sairei To, Shan Chi, Shen Min, Shi Can, Shi Liu Pi, Shou Wu Pian, Tian Hua Fen, White flood, Wu Bei Zi, Xi Shu, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, Zhen Chu Cao, and various unclassified Chinese herbal mixtures. Causality was firmly established for a number of herbal TCM products by a positive reexposure test result, the liver specific scale of CIOMS (Council for International Organizations of Medical Sciences), or both. Otherwise, the quality of case data was mixed, especially regarding analysis of the herb ingredients because of adulteration with synthetic drugs, contamination with heavy metals, and misidentification. In addition, non-herbal TCM elements derived from Agaricus blazei, Agkistrodon, Antelope, Bombyx, Carp, Fish gallbladder, Phellinus, Scolopendra, Scorpio, and Zaocys are also known or potential hepatotoxins. For some patients, the clinical course was severe, with risks for acute liver failure, liver transplantation requirement, and lethality. In conclusion, the use of few herbal TCM products may rarely be associated with hepatotoxicity in some susceptible individuals, necessitating a stringent pretreatment evaluation of the risk/benefit ratio, based on results of multicenter, randomized, double-blind, placebo-controlled clinical trials.
Evaluation of the Sensor Data Record from the nadir instruments of the Ozone Mapping Profiler Suite (OMPS)

This paper evaluates the first 15 months of the Ozone Mapping and Profiler Suite (OMPS) Sensor Data Record (SDR) acquired by the nadir sensors and processed by the National Oceanic and Atmospheric Administration Interface Data Processing Segment. The evaluation consists of an inter‐comparison with a similar satellite instrument, an analysis using a radiative transfer model, and an assessment of product stability. This is in addition to the evaluation of sensor calibration and the Environment Data Record product that are also reported in this Special Issue. All these are parts of synergetic effort to provide comprehensive assessment at every level of the products to ensure its quality. It is found that the OMPS nadir SDR quality is satisfactory for the current Provisional maturity. Methods used in the evaluation are being further refined, developed, and expanded, in collaboration with international community through the Global Space‐based Inter‐Calibration System, to support the upcoming long‐term monitoring.
Modeling tradeoffs in avian life history traits and consequences for population growth

Variation in population dynamics is inherently related to life history characteristics of species, which vary markedly even within phylogenetic groups such as passerine birds. We computed the finite rate of population change ( ) from a matrix projection model and from mark-recapture observations for 23 bird species breeding in northern Arizona. We used sensitivity analyses and a simulation model to separate contributions of different life history traits to population growth rate. In particular we focused on contrasting effects of components of reproduction (nest success, clutch size, number of clutches, and juvenile survival) versus adult survival on . We explored how changes in nest success or adult survival coupled to costs in other life history parameters affected over a life history gradient provided by our 23 Arizona species, as well as a broader sample of 121 North American passerine species. We further examined these effects for more than 200 passeriform and piciform populations breeding across North America. Model simulations indicate nest success and juvenile survival exert the largest effects on population growth in species with moderate to high reproductive output, whereas adult survival contributed more to population growth in long-lived species. Our simulations suggest that monitoring breeding success in populations across a broad geographic area provides an important index for identifying neotropical migratory populations at risk of serious population declines and a potential method for identifying large-scale mechanisms regulating population dynamics. © 2007 Elsevier B.V. All rights reserved.
A Tri-national Study of Accountancy Students' Ethical Attitudes

Ethics is an integral part of the accountancy profession. As the profession becomes more internationalized, it is critical to accept that different nations may still advocate differing treatments for similar issues. This study evaluates whether the accountants of tomorrow already display differences in their attitudes, based upon nationality. The attitudes of final year accountancy students from three countries, Malaysia, Australia and Ireland were compared across some ethical scenarios. Significant differences were found to exist based upon nationality. When confronted with bribery/corruption scenarios, Malaysian students were most likely to refuse participation but do nothing about them. Australian students were more likely to inform the relevant authorities. Irish students were more likely to participate than their Malaysian and Australian counterparts. Malaysian students were more likely to cheat in an exam than participate in corruption, whereas Irish and Australian students were more likely to do the opposite. Hence ethical attitudes are affected by nationalistic traits. The ramifications for professional training should therefore be considered.
Nutritional Risk Screening 2002 as a Predictor of Postoperative Outcomes in Patients Undergoing Abdominal Surgery: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

Background The nutritional risk screening (NRS 2002) has been applied increasingly in patients who underwent abdominal surgery for nutritional risk assessment. However, the usefulness of the NRS 2002 for predicting is controversial. This meta-analysis was to examine whether a preoperative evaluation of nutritional risk by NRS 2002 provided prediction of postoperative outcomes in patients undergoing abdominal surgery. Methods A systematic literature search for published papers was conducted using the following online databases: MEDLINE, EMBASE, the Cochrane library, EBSCO, CRD databases, Cinahl, PsycInfo and BIOSIS previews. The pooled odds ratio (OR) or weight mean difference (WMD) was calculated using a random-effect model or a fix-effect model. Results Eleven studies with a total of 3527 patients included in this study. Postoperative overall complications were more frequent in nutritional risk patients versus patients without nutritional risk (the pooled OR 3.13 [2.51, 3.90] p<0.00001). The pooled OR of mortality for the nutritional risk group and non-nutritional risk group was 3.61 [1.38, 9.47] (p = 0.009). Furthermore, the postoperative hospital stay was significant longer in the preoperative nutritional risk group than in the nutritional normal group (WMD 5.58 [4.21, 6.95] p<0.00001). Conclusions The present study has demonstrated that patients at preoperative nutritional risk have increased complication rates, high mortality and prolonged hospital stay after surgery. However, NRS 2002 needs to be validated in larger samples of patients undergoing abdominal surgery by better reference method.
DO NON-R & D INTENSIVE INDUSTRIES BENEFIT FROM PUBLIC RESEARCH SPILLOVERS ? THE CASE OF THE AGRO-FOOD INDUSTRY

The agro-food industry is a sector in which the percentage of firms which have done innovation in the past three years is high, whereas they have a low research capacity. According to an innovation survey (1986-90) in France, 70% of agro-food firms which responded in the Community Innovation Survey (CIS), reported innovations while less than 5% of them had internal research capacities. Our paper models estimates of determinants of innovation in the agro-food industry. Based on the comparison of several French databases (annual survey on firms, on innovation, on R&D in firms, on R&D in academic labs), it explores the determinants of innovation: sources of innovation (as defined in CIS), spillovers from public research and spillovers from other firms. Since agro-food firms have a low absorptive capacity, we assume that the transfer of knowledge from public research or from large firms to agro-food firms is based on geographical proximity. The paper presents three main results: 1. Intensity of innovation (defined as radical innovation versus incremental innovation) is linked with the presence of public research in life science in the same region. 2. Spillovers form academic laboratories do exist even if firms have no absorptive capacity. * The authors wish to thank the Rhône Alpes Region and the INRA/DADP for their financial support for this research. Aupelf/Urelf enabled us to initiate collaboration with UQAM, and we are indebted to them for that assistance. We also benefited from comments by the steering committee and the scientific committee of the INRA/DADP – Rhône-Alpes project, and wish to thank them for their stimulating remarks. We similarly benefited from comments made at the TSER workshop Innovation and Economic Change: Exploring CIS micro data, Delft, 12-13 February 1999. Of course, the usual restrictions about the responsibility of mistakes apply. ha l-0 04 24 28 6, v er si on 1 14 O ct 2 00 9 Author manuscript, published in "Innovation and Firm Performance. Econometric Explorations of Survey Data, A. Kleinknecht et P. Monhen (Ed.) (2001) 23 p."
WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma.

Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4 (4p16.3). The smallest region of overlap between WHS patients, the WHS critical region, has been confined to 165 kb, of which the complete sequence is known. We have identified and studied a 90 kb gene, designated as WHSC1 , mapping to the 165 kb WHS critical region. This 25 exon gene is expressed ubiquitously in early development and undergoes complex alternative splicing and differential polyadenylation. It encodes a 136 kDa protein containing four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain also found in the Drosophila dysmorphy gene ash -encoded protein, and a PHD-type zinc finger. It is expressed preferentially in rapidly growing embryonic tissues, in a pattern corresponding to affected organs in WHS patients. The nature of the protein motifs, the expression pattern and its mapping to the critical region led us to propose WHSC1 as a good candidate gene to be responsible for many of the phenotypic features of WHS. Finally, as a serendipitous finding, of the t(4;14) (p16.3;q32.3) translocations recently described in multiple myelomas, at least three breakpoints merge the IgH and WHSC1 genes, potentially causing fusion proteins replacing WHSC1 exons 1-4 by the IgH 5'-VDJ moiety.
Fashion: A Philosophy

Donatella Versace and Jean-Paul Gaultier, Yves Saint Laurent and Giorgio Armani, Dolce & Gabbana and Gucci: fashion is at once a familiar yet mysteriously elite world that we all experience, whether we're buying a new pair of jeans, reading Vogue, or watching the latest episode of America's Next Top Model. Lars Svendsen dives into this world in "Fashion: A Philosophy", exploring the myths, ideas, and history that makes up haute couture, the must-have trends over the centuries, and the very concept of fashion itself. "Fashion" opens with an exploration of all the possible meanings encompassed by the word fashion', as Svendsen probes its elusive place in art, politics, and history. Ultimately, however, he focuses on the most notable type of fashion: clothing. With his trademark dry wit, he deftly dismantles many of the axioms of the industry and its supporters. For example, he points out that some of the latest fashions shown on catwalks aren't actually fashionable' in any sense of the word, arguing that they're more akin to modern art works, and he argues against the increasingly popular idea that plastic surgery and body modification are part of a new wave of consumerism. Svendsen draws upon the writings of thinkers from Adam Smith to Roland Barthes to analyse fashion as both a historical phenomenon and a philosophy of aesthetics. Whether critiquing a relentless media culture that promotes perfect bodies or parsing the never-ending debate over the merits of conformity versus individual style, Lars Svendsen offers an engaging and intriguing analysis of fashion and the motivations behind its constant pursuit for the new.
The Impact of Bilingualism on Working Memory: A Null Effect on the Whole May Not Be So on the Parts

Abundant research has examined the relationship between bilingualism and working memory (WM), a system that keeps information accessible while dealing with concurrent processes, distractions, or attention shifts (Baddeley and Hitch, 1974; Engle et al., 1999; Conway et al., 2002). Some studies have reported no WM differences between bilinguals and monolinguals (Bialystok et al., 2008; Feng, 2009; Bialystok, 2010; Namazi and Thordardottir, 2010; Bonifacci et al., 2011; Engel de Abreu, 2011), leading top scholars to maintain that this domain is impervious to bilingualism. For instance, Bialystok (2009) first claimed that WM is indifferent to the development of a non-native language (L2). Later, she slightly reframed her position, stating that WM is only occasionally enhanced by the bilingual experience (e.g., Bialystok et al., 2009, 2012). Likewise, in another study, Engel de Abreu (2011: p. 6) concluded that “bilingual experience does not seem to convey any advantage in working memory abilities,” which aligns with recent criticism on the very notion of bilingual benefits (Dunabeitia and Carreiras, 2015; Calvo et al., 2016; Paap et al., 2016).