Miracle-dz/UniFAR-FTUs huggingface dataset:
How Persistent are Shocks to GDP ? Evidence from the Forecasting Community

This paper uses forecast revisions to provide direct evidence on the persistence of shocks to GDP. The evidence from the forecasting record of professional, academic and government economists suggests that innovations in GDP exhibit far greater persistence than would be implied by simple trend stationary models. Instead, the persistence matches or exceeds the levels of persistence generated by low-order ARIMA models. Preliminary and incomplete. Suggestions and comments needed. 1 Associate Professor, University of Nebraska-Lincoln, Department of Economics, 352 College of Business Administration, P.O. Box 880489, Lincoln, NE 68588-0489, (402) 472-2323, FAX (402) 472-9700, mcushing1@unl.edu.
The amygdala and the relevance detection theory of autism: an evolutionary perspective

In the last few decades there has been increasing interest in the role of the amygdala in psychiatric disorders and, in particular, in its contribution to the socio-emotional impairments in autism spectrum disorders (ASDs). Given that the amygdala is a component structure of the “social brain,” several theoretical explanations compatible with amygdala dysfunction have been proposed to account for socio-emotional impairments in ASDs, including abnormal eye contact, gaze monitoring, face processing, mental state understanding, and empathy. Nevertheless, many theoretical accounts, based on the Amygdala Theory of Autism, fail to elucidate the complex pattern of impairments observed in this population, which extends beyond the social domain. As posited by the Relevance Detector theory (Sander et al., 2003), the human amygdala is a critical component of a brain circuit involved in the appraisal of self-relevant events that include, but are not restricted to, social stimuli. Here, we propose that the behavioral and social–emotional features of ASDs may be better understood in terms of a disruption in a “Relevance Detector Network” affecting the processing of stimuli that are relevant for the organism’s self-regulating functions. In the present review, we will first summarize the main literature supporting the involvement of the amygdala in socio-emotional disturbances in ASDs. Next, we will present a revised version of the Amygdala Relevance Detector hypothesis and we will show that this theoretical framework can provide a better understanding of the heterogeneity of the impairments and symptomatology of ASDs. Finally, we will discuss some predictions of our model, and suggest new directions in the investigation of the role of the amygdala within the more generally disrupted cortical connectivity framework as a model of neural organization of the autistic brain.
A Socioecological Model for Advanced Service Discovery in Machine-to-Machine Communication Networks

The new development of embedded systems has the potential to revolutionize our lives and will have a significant impact on future Internet of Thing (IoT) systems if required services can be automatically discovered and accessed at runtime in Machine-to-Machine (M2M) communication networks. It is a crucial task for devices to perform timely service discovery in a dynamic environment of IoTs. In this article, we propose a Socioecological Service Discovery (SESD) model for advanced service discovery in M2M communication networks. In the SESD network, each device can perform advanced service search to dynamically resolve complex enquires and autonomously support and co-operate with each other to quickly discover and self-configure any services available in M2M communication networks to deliver a real-time capability. The proposed model has been systematically evaluated and simulated in a dynamic M2M environment. The experiment results show that SESD can self-adapt and self-organize themselves in real time to generate higher flexibility and adaptability and achieve a better performance than the existing methods in terms of the number of discovered service and a better efficiency in terms of the number of discovered services per message.
Reproduction in male rats is vulnerable to treatment with the flavonoid‐rich seed extracts of Vitex negundo

A partially puriﬁed ﬂavonoid‐rich extract was prepared from the seed of Vitex negundo. The effect of this extract on the reproductive system of male rats was investigated at four different concentrations. All the major accessory sex organs shed weight when the preparation was administered at doses of ≥15 mg/rat/day after 15 days of treatment. The drop in weight was also reﬂected in disturbed tissue biochemistry. Secretory products such as citric acid in the prostate, fructose in seminal vesicles and epididymal α‐glucosidase activity, indices of accessory sex organ function in males, diminished. Microscopic examination of the sperm derived from the cauda epididymides of treated animals showed only a marginal change in vitality. However, sperm numbers dwindled and slackness in their motility was observed, factors that may impede fertility. Toxicity testing in blood did not point to distress in any of the vital organs. Taken together, it is inferred that the seed extracts of V. negundo interfere with male reproductive function without producing adverse toxicity in other vital organs. Copyright © 2004 John Wiley & Sons, Ltd.
High Energy Emission from Rotation-Powered Pulsars: Outer-gap vs. Slot-gap Models

We explore particle accelerator electrodynamics in the magnetosphere of a rapidly rotating neutron star (NS). We address the importance of a self-consistent treatment of pair production, solving the Poisson equation describing the acceleration electric field, the Boltzmann equations for produced electrons and positrons, and the radiative transfer equation simultaneously. It is demonstrated that the accelerator solution is obtained if we only specify the NS spin period, magnetic dipole moment, magnetic inclination angle with respect to the rotation axis, and the NS surface temperature, and that the solution corresponds to a quantitative extension of previous outer-gap models. We apply the scheme to the Crab pulsar and show that the predicted pulse profiles and phase-resolved spectrum are roughly consistent with observations. Applying the same scheme to the slot-gap model, we show that this alternative model predicts too small photon flux to reproduce observations, because the gap trans-field thickness is significantly restricted by its pair-free condition.
Revisiting the Nystrom Method for Improved Large-scale Machine Learning

We reconsider randomized algorithms for the low-rank approximation of SPSD matrices such as Laplacian and kernel matrices that arise in data analysis and machine learning applications. Our main results consist of an empirical evaluation of the performance quality and running time of sampling and projection methods on a diverse suite of SPSD matrices. Our results highlight complementary aspects of sampling versus projection methods, and they point to differences between uniform and nonuniform sampling methods based on leverage scores. We complement our empirical results with a suite of worst-case theoretical bounds for both random sampling and random projection methods. These bounds are qualitatively superior to existing bounds--e.g., improved additive-error bounds for spectral and Frobenius norm error and relative-error bounds for trace norm error.
The Importance of Integration of Stakeholder Views in Core Outcome Set Development: Otitis Media with Effusion in Children with Cleft Palate

Background Approximately 75% of children with cleft palate (CP) have Otitis Media with Effusion (OME) histories. Evidence for the effective management of OME in these children is lacking. The inconsistency in outcome measurement in previous studies has led to a call for the development of a Core Outcome Set (COS). Despite the increase in the number of published COS, involvement of patients in the COS development process, and methods to integrate the views of patients and health professionals, to date have been limited. Methods and Findings A list of outcomes measured in previous research was identified through reviewing the literature. Opinion on the importance of each of these outcomes was then sought from key stakeholders: Ear, Nose and Throat (ENT) surgeons, audiologists, cleft surgeons, speech and language therapists, specialist cleft nurses, psychologists, parents and children. The opinion of health professionals was sought in a three round Delphi survey where participants were asked to score each outcome using a bespoke online system. Parents and children were also asked to score outcomes in a survey and provided an in-depth insight into having OME through semi-structured interviews. The results of the Delphi survey, interviews and parent/patient survey were brought together in a final consensus meeting with representation from all stakeholders. A final set of eleven outcomes reached the definition of “consensus in” to form the recommended COS: hearing; chronic otitis media (COM); OME; receptive language skills; speech development; psycho social development; acute otitis media (AOM); cholesteatoma; side effects of treatment; listening skills; otalgia. Conclusions We have produced a recommendation about the outcomes that should be measured, as a minimum, in studies of the management of OME in children with CP. The development process included input from key stakeholders and used novel methodology to integrate the opinion of healthcare professionals, parents and children.
Are Environmental Levels of Bisphenol A Associated with Reproductive Function in Fertile Men?

Background Rodent and in vitro studies have demonstrated the estrogenicity of bisphenol A (BPA). However, few studies have examined the relationship between human exposure to BPA and male reproductive function. Objectives We investigated the relationships between environmental BPA exposure and reproductive parameters, including semen quality and male reproductive hormones, in prospectively recruited fertile men. Methods Participants (n = 375) were partners of pregnant women who participated in the Study for Future Families in four U.S. cities, and all of the men provided blood, semen, and urine samples. BPA was measured in urine. Serum samples were analyzed for reproductive hormones, including follicle-stimulating hormone, luteinizing hormone (LH), testosterone, inhibin B, estradiol, and sex hormone–binding globulin (SHBG), as well as the free androgen index (FAI). Semen analyses were performed according to World Health Organization criteria. Pearson correlations were used for unadjusted analyses, and multiple linear regression analyses were used to examine associations controlling for age, body mass index, smoking, ethnicity, urinary creatinine concentration, time of sample collection, and duration of abstinence. Results After multivariate adjustment, we observed no significant associations between any semen parameter and urinary BPA concentration. However, a significant inverse association was found between urinary BPA concentration and FAI levels and the FAI/LH ratio, as well as a significant positive association between BPA and SHBG. Conclusions Our results suggest that, in fertile men, exposure to low environmental levels of BPA may be associated with a modest reduction in markers of free testosterone, but any effects on reproductive function are likely to be small, and of uncertain clinical significance.
Particle Size Effects of TiO2 Layers on the Solar Efficiency of Dye-Sensitized Solar Cells

Large particle sizes having a strong light scattering lead to a significantly decreased surface area and small particle sizes having large surface area lack light-scattering effect. How to combine large and small particle sizes together is an interesting work for achieving higher solar efficiency. In this work, we investigate the solar performance influence of the dye-sensitized solar cells (DSSCs) by the multiple titanium oxide (TiO2) layers with different particle sizes. It was found that the optimal TiO2 thickness depends on the particle sizes of TiO2 layers for achieving the maximum efficiency. The solar efficiency of DSSCs prepared by triple TiO2 layers with different particle sizes is higher than that by double TiO2 layers for the same TiO2 thickness. The choice of particle size in the bottom layer is more important than that in the top layer for achieving higher solar efficiency. The choice of the particle sizes in the middle layer depends on the particle sizes in the bottom and top layers. The mixing of the particle sizes in the middle layer is a good choice for achieving higher solar efficiency.
Health-related social disengagement in elderly diabetic patients: association with subsequent disability and survival.

OBJECTIVE We examined the relationship between health-related social disengagements, as opposed to disengagements related to financial and other non-health-related factors, and subsequent risk of disability and death among initially nondisabled elderly diabetic patients enrolled in Medicare Managed Care plans. RESEARCH DESIGN AND METHODS We used data from the Medicare Health Outcomes Survey (HOS) Cohort 1 Baseline (1998) and Cohort 1 Follow-Up (2000). Through mail and telephone surveys, trained interviewers collected information on sociodemographic variables, physical and mental health functioning (using Medical Outcomes Study Short Form-36 [SF-36]), activities of daily living (ADL), and medical conditions. This study reported on diabetic subjects aged >or=65 years with no ADL disability at baseline (n = 8949). Health-related social disengagement (degree to which physical health or emotional problems interfere with social activities) was derived from the social functioning subscale of SF-36 (range 0-100; higher scores depicting better social functioning). RESULTS For each 10-point increase in social functioning score at baseline, older diabetic subjects in our study experienced an 18% less chance of any ADL disability (odds ratio [OR] 0.82, 95% CI 0.75-0.89; P < 0.001) and a 12% less chance of death (0.88, 0.78-1.00; P = 0.043) over a 2-year period, adjusting for demographic factors, comorbidities, depression, and general health (assessed by the SF-36). CONCLUSIONS Among initially nondisabled older diabetic subjects, health-related interferences with social activities at baseline may be early warning signs of subsequent ADL disability and premature death, independent of other measures of health status.
Pathological Correlates of Late Drug-Eluting Stent Thrombosis: Strut Coverage as a Marker of Endothelialization

Background— Late stent thrombosis (LST) after Cypher and Taxus drug-eluting stent placement has emerged as a major concern. Although the clinical predictors of LST have been reported, specific morphological and histological correlates of LST remain unknown. Methods and Results— From a registry totaling 81 human autopsies of drug-eluting stents, 46 (62 lesions) had a drug-eluting stent implanted >30 days. We identified 28 lesions with thrombus and compared those with 34 of similar duration without thrombosis using computer-guided morphometric and histological analyses. LST was defined as an acute thrombus within a coronary artery stent in place >30 days. Multiple logistic generalized estimating equations modeling demonstrated that endothelialization was the best predictor of thrombosis. The morphometric parameter that best correlated with endothelialization was the ratio of uncovered to total stent struts per section. A univariable logistic generalized estimating equations model of occurrence of thrombus in a stent section versus ratio of uncovered to total stent struts per section demonstrated a marked increase in risk for LST as the number of uncovered struts increased. The odds ratio for thrombus in a stent with a ratio of uncovered to total stent struts per section >30% is 9.0 (95% CI, 3.5 to 22). Conclusions— The most powerful histological predictor of stent thrombosis was endothelial coverage. The best morphometric predictor of LST was the ratio of uncovered to total stent struts. Heterogeneity of healing is a common finding in drug-eluting stents with evidence of LST and demonstrates the importance of incomplete healing of the stented segment in the pathophysiology of LST.
The role of food standards in international trade: assessing the brazilian beef chain

The purpose of this paper is to identify how Brazilian beef managers have responded to a rapid expansion and intensification of standards for beef exports. This issue relates to how some Brazilian beef exporters are strategically repositioning themselves in the supply chains. The literature of this study reviews global chain governance and international standards. The method uses case studies consisting of six medium and large scale beef exporters who export fresh beef to the European Union. The main findings describe the kinds of governance that stimulate upgrading and transferral of the best practices and, consequently, full compliance with mandatory standards. This study suggests that standards do matter for companies trying to increase international competitiveness. These results contribute an understanding of the Brazilian beef chain, and also of other supply chains coping with demanding and changing international markets. Managerial implications show the challenges facing Brazilian beef exporters in their efforts to sustain exports to the European Union and how they are using chain governance to improve their compliance with international standards and increase competitiveness.
Helicobacter hepaticus Triggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism

ABSTRACT Mice rendered deficient in interleukin-10 (IL-10) by gene targeting (IL-10−/− mice) develop chronic enterocolitis resembling human inflammatory bowel disease (IBD) when maintained in conventional animal facilities. However, they display a minimal and delayed intestinal inflammatory response when reared under specific-pathogen-free (SPF) conditions, suggesting the involvement of a microbial component in pathogenesis. We show here that experimental infection with a single bacterial agent, Helicobacter hepaticus, induces chronic colitis in SPF-reared IL-10−/− mice and that the disease is accompanied by a type 1 cytokine response (gamma interferon [IFN-γ], tumor necrosis factor alpha, and nitric oxide) detected by restimulation of spleen and mesenteric lymph node cells with a soluble H. hepaticusantigen (Ag) preparation. In contrast, wild-type (WT) animals infected with the same bacteria did not develop disease and produced IL-10 as the dominant cytokine in response to Helicobacter Ag. Strong H. hepaticus-reactive antibody responses as measured by Ag-specific total immunoglobulin G (IgG), IgG1, IgG2a, IgG2b, IgG3, and IgA were observed in both WT and IL-10−/− mice. In vivo neutralization of IFN-γ or IL-12 resulted in a significant reduction of intestinal inflammation in H. hepaticus-infected IL-10−/− mice, suggesting an important role for these cytokines in the development of colitis in the model. Taken together, these microbial reconstitution experiments formally establish that a defined bacterial agent can serve as the immunological target in the development of large bowel inflammation in IL-10−/− mice and argue that in nonimmunocompromised hosts IL-10 stimulated in response to intestinal flora is important in preventing IBD.
Health‐Promotion Behaviors of Undergraduate Nursing Students: A Survey Analysis

AIM To examine health promotion behaviors and barriers to health promotion in traditional and nontraditional nursing students in an associate degree nursing program in the northeastern United States. BACKGROUND Nursing students are exposed to concepts of health promotion in the nursing curriculum, but do not necessarily apply them to their own lives. Examining the variables affecting the health behaviors of nursing students may provide the information required to motivate lifestyle changes in this population. METHOD A cross‐sectional descriptive design was used to examine the relationship between study variables. RESULTS Nontraditional nursing students participate in health promoting behaviors less often than traditional nursing students and experience more barriers to health promotion. CONCLUSION Implementation of health promotion programs targeting nontraditional students may lead to improved health among these individuals, which may result in increased success in nursing programs.
Improved control of epilepsy by monitoring plasma ethosuximide.

Plasma ethosuximide level was monitored in 70 patients with absence (petit mal) seizures. Levels were linearly related to administered dose. Of 37 ambulatory patients with uncontrolled attacks, 38% (14) had levels below the 95% tolerance limit in contrast to 9% (5) of the controlled group. This difference, due to noncompliance with therapy, was eliminated by regular monitoring. Appropriate adjustment of plasma ethosuximide levels resulted in a reduction of seizures in 48% (18) of previously uncontrolled patients. Practical control of epilepsy increased from 64% (45) to 81% (57). Monitoring of plasma ethosuximide increases the effectiveness of therapy by the recognition of noncompliance and the individualization of drug requirements.
Too Masculine, Too Bad

This study challenges researchers and practitioners in the field of leadership to consider communion as a relevant variable for (male) leadership effectiveness. We suggest that communal traits influence the ability of male leaders to engender cooperation and that this effect is stronger in male-dominated contexts. We argue that this is because relevant traits and leadership behaviors that underscore a sense of community are associated with stereotypically feminine roles and identity. In a series of three studies, experimental as well as survey-based, using Spanish, Dutch, and American samples, we examined such gendered construction of male leadership and its effects on cooperation. Among others, results are discussed in terms of how stereotypically masculine constructions of male leadership may create barriers to effective leadership.
Litigating Socio-Economic Rights in South Africa : A Choice between Corrective and Distributive Justice, Christopher Mbazira Constitutional Deference, Courts and Socio-Economic Rights in South Africa, Kirsty McLean : book review

Christopher Mbazira and Kirsty McLean's books, both adapted from doctoral theses and published by Pretoria University Law Press, are welcome additions to the growing scholarship on socio-economic rights litigation in South Africa. Both books are very readable, while being well-researched and academically rigorous, and are likely to appeal to law students and practitioners alike.