Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of Pediatric Ulcerative Colitis: Joint ECCO and ESPGHAN Evidence-based Consensus Guidelines

Background and Aims: Pediatric ulcerative colitis (UC) shares many features with adult-onset disease but there are some unique considerations; therefore, therapeutic approaches have to be adapted to these particular needs. We aimed to formulate guidelines for managing UC in children based on a systematic review (SR) of the literature and a robust consensus process. The present article is a product of a joint effort of the European Crohn's and Colitis Organization (ECCO) and the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). Methods: A group of 27 experts in pediatric IBD participated in an iterative consensus process including 2 face-to-face meetings, following an open call to ESPGHAN and ECCO members. A list of 23 predefined questions were addressed by working subgroups based on a SR of the literature. Results: A total of 40 formal recommendations and 68 practice points were endorsed with a consensus rate of at least 89% regarding initial evaluation, how to monitor disease activity, the role of endoscopic evaluation, medical and surgical therapy, timing and choice of each medication, the role of combined therapy, and when to stop medications. A management flowchart, based on the Pediatric Ulcerative Colitis Activity Index (PUCAI), is presented. Conclusions: These guidelines provide clinically useful points to guide the management of UC in children. Taken together, the recommendations offer a standardized protocol that allows effective, timely management and monitoring of the disease course, while acknowledging that each patient is unique.
Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude.

High altitude decreases birth weight, but this effect is diminished in long vs. short-resident, high-altitude populations. We asked whether women from long vs. short-resident, high-altitude populations had higher arterial oxygenation levels by comparing 42 Andean and 26 European residents of La Paz, Bolivia (3,600 m), serially during pregnancy (weeks 20, 30, and 36) and again 4 mo postpartum. Pregnancy raised hypoxic ventilatory sensitivity threefold, resting ventilation (.Ve), and arterial O(2) saturation (Sa(O2)) in both groups. Ancestry, as identified using 81 genetic markers, correlated with respiratory pattern, such that greater Andean ancestry was associated with higher respiratory frequency and lower tidal volume. Pregnancy increased total blood and plasma volume approximately 40% in both groups without changing red blood cell mass relative to body weight; hence, hemoglobin fell. The hemoglobin decline was compensated for by the rise in . Ve and Sa(O2) with the result that arterial O2 content (Ca(O2)) was maintained near nonpregnant levels in both groups. Birth weights were similar for all Andean and European babies, but after adjusting for variation in gestational age, maternal height and parity, Andeans weighed 209 g more than Europeans. Babies with heavier birth weights and greater ponderal indices were born to Andean women with higher Ve during pregnancy. We concluded that while maternal . Ve and arterial oxygenation were important, some factor other than higher Ca(O2) was responsible for protecting Andeans from altitude-associated reductions in fetal growth.
Prevalence of smoking and high blood pressure, two major risk factors for non-communicable diseases: the SuRF NCD (surveillance of risk factors of non-communicable disease) report 2012

Introduction: In recent years non-communicable diseases (NCDs) risk factors such as tobacco consumption and high blood pressure (BP) have been increased. This study aimed to determine the frequency of risk factors of the main NCDs among inhabitants of Rafsanjan city. Methods: Our study is a part of NCD surveillance in Iran (SuRF NCD). A total of 640 people enrolled and divided in four age groups in urban and rural areas in Rafsanjan (a city in Kerman province). Data were collected using the standardized stepwise protocol for NCD risk factor surveillance of the World Health Organization (WHO). This study focused on hypertension (HTN) and smoking. Results: A total of 640 people (46.9% male and 53.1% female) participated in this cross-sectional study. The prevalence of HTN was 198 per 1000 population. 4.8% of those were below the age of 44, and 15% between 45 and 70 years old. Mean systolic BP was 127 ± 15.6 in male and 118 ± 19.65 in female and the statistical difference was significant (t = 5.55, P < 0.001). 79 (14.1%) of hypertensive live in urban and 32 (5.7%) live in rural areas (χ2 = 8.004, P = 0.005). The prevalence of current smokers was 112 per 1000 population; among them 56 (88.9%) were daily smokers. The mean age for starting smoking was 21.11 ± 7.16 years. Conclusion: Modifying risk factors such as HTN and smoking behavior through primary and secondary prevention programs by enhancing awareness and knowledge of lay people, improvement screening and treatment interventions, particularly for the youth is highly recommended.
Examining the tectono-stratigraphic architecture, structural geometry, and kinematic evolution of the Himalayan fold-thrust belt, Kumaun, northwest India

Existing structural models of the Himalayan fold-thrust belt in Kumaun, northwest India, are based on a tectono-stratigraphy that assigns different stratigraphy to the Ramgarh, Berinag, Askot, and Munsiari thrusts and treats the thrusts as separate structures. We reassess the tectono-stratigraphy of Kumaun, based on new and existing U-Pb zircon ages and whole-rock Nd isotopic values, and present a new structural model and deformation history through kinematic analysis using a balanced cross section. This study reveals that the rocks that currently crop out as the Ramgarh, Berinag, Askot, and Munsiari thrust sheets were part of the same, once laterally continuous stratigraphic unit, consisting of Lesser Himalayan Paleoproterozoic granitoids (ca. 1850 Ma) and metasedimentary rocks. These Paleoproterozoic rocks were shortened and duplexed into the Ramgarh-Munsiari thrust sheet and other Paleoproterozoic thrust sheets during Himalayan orogenesis. Our structural model contains a hinterland-dipping duplex that accommodates ∼541–575 km or 79%–80% of minimum shortening between the Main Frontal thrust and South Tibetan Detachment system. By adding in minimum shortening from the Tethyan Himalaya, we estimate a total minimum shortening of ∼674–751 km in the Himalayan fold-thrust belt. The Ramgarh-Munsiari thrust sheet and the Lesser Himalayan duplex are breached by erosion, separating the Paleoproterozoic Lesser Himalayan rocks of the Ramgarh-Munsiari thrust into the isolated, synclinal Almora, Askot, and Chiplakot klippen, where folding of the Ramgarh-Munsiari thrust sheet by the Lesser Himalayan duplex controls preservation of these klippen. The Ramgarh-Munsiari thrust carries the Paleoproterozoic Lesser Himalayan rocks ∼120 km southward from the footwall of the Main Central thrust and exposed them in the hanging wall of the Main Boundary thrust. Our kinematic model demonstrates that propagation of the thrust belt occurred from north to south with minor out-of-sequence thrusting and is consistent with a critical taper model for growth of the Himalayan thrust belt, following emplacement of midcrustal Greater Himalayan rocks. Our revised stratigraphy-based balanced cross section contains ∼120–200 km greater shortening than previously estimated through the Greater, Lesser, and Subhimalayan rocks.
ON SPECIAL GENERALIZED CALABI-YAU MANIFOLDS

We construct examples of special generalized Calabi-Yau manifolds on compact quotients of solvable Lie groups. We prove that the CalabiYau structures are not rigid in the class of special generalized Calabi-Yau structures. Moreover, we provide an example of a compact 6-dimensional special generalized Calabi-Yau manifold whose real part of the complex volume form is d-exact. Finally we discuss the 4-dimensional case.
Creativity in problem solving: Uncovering the origin of new ideas

Innovation and enterprise depend for their success on the development of new ideas. But from where do new ideas come? How do they arise? Finding solutions to such questions is at the heart of creativity research and the solving of novel problems. Reflection, not only in cognitive processes but also in the non-cognitive ones used in solving novel mathematics problems, is uncovering a way in which the origins of new ideas occur. A study involving protocol analysis of five expert problem solvers identifies three critical elements. These elements have been employed to construct a framework of creative problem solving which may be used to foster creativity among young people under instruction and provide a cognitive explanation of the origin of new ideas.
Is There a Role for Probiotics in Liver Disease?

Intestinal microbiota plays an important role in health and disease. Alteration in its healthy homeostasis may result in the development of numerous liver disorders including complications of liver cirrhosis. On the other hand, restoration and modulation of intestinal flora through the use of probiotics is potentially an emerging therapeutic strategy. There is mounting evidence that probiotics are effective in the treatment of covert and overt hepatic encephalopathy, as well as in the prevention of recurrence of encephalopathy. The beneficial effect of probiotics also extends to liver function in cirrhosis, nonalcoholic fatty liver disease, and alcoholic liver disease. On the other hand, data associating probiotics and portal hypertension is scanty and conflicting. Probiotic therapy has also not been shown to prevent primary or secondary spontaneous bacterial peritonitis. Larger clinical studies are required before probiotics can be recommended as a treatment modality in liver diseases.
Localization of Brain-Derived Neurotrophic Factor to Distinct Terminals of Mossy Fiber Axons Implies Regulation of Both Excitation and Feedforward Inhibition of CA3 Pyramidal Cells

Hippocampal dentate granule cells directly excite and indirectly inhibit CA3 pyramidal cells via distinct presynaptic terminal specializations of their mossy fiber axons. This mossy fiber pathway contains the highest concentration of brain-derived neurotrophic factor (BDNF) in the CNS, yet whether BDNF is positioned to regulate the excitatory and/or inhibitory pathways is unknown. To localize BDNF, confocal microscopy of green fluorescent protein transgenic mice was combined with BDNF immunohistochemistry. Approximately half of presynaptic granule cell-CA3 pyramidal cell contacts were found to contain BDNF. Moreover, enhanced neuronal activity virtually doubled the percentage of BDNF-immunoreactive terminals contacting CA3 pyramidal cells. To our surprise, BDNF was also found in mossy fiber terminals contacting inhibitory neurons. These studies demonstrate that mossy fiber BDNF is poised to regulate both direct excitatory and indirect feedforward inhibitory inputs to CA3 pyramdal cells and reveal that seizure activity increases the pool of BDNF-expressing granule cell presynaptic terminals contacting CA3 pyramidal cells.
Regulation of Solute Flux through Plasmodesmata in the Root Meristem1[W][OA]

Plasmodesmata permit solutes to move between cells nonspecifically and without having to cross a membrane. This symplastic connectivity, while straightforward to observe using fluorescent tracers, has proven difficult to quantify. We use fluorescence recovery after photobleaching, combined with a mathematical model of symplastic diffusion, to assay plasmodesmata-mediated permeability in the Arabidopsis (Arabidopsis thaliana) root meristem in wild-type and transgenic lines, and under selected chemical treatments. The permeability measured for the wild type is nearly 10-times greater than previously reported. Plamodesmal permeability remains constant in seedlings treated with auxin (30 nm indoleacetic acid for 2 and 24 h; 100 nm indoleacetic acid for 2 h); however, permeability is diminished in two lines previously reported to have impaired plasmodesmal function as well as in wild-type seedlings treated for 24 h with 0.6 mm tryptophan. Moreover, plasmodesmal permeability is strongly altered by applied hydrogen peroxide within 2 h of treatment, being approximately doubled at a low concentration (0.6 mm) and nearly eliminated at a higher one (6 mm). These results reveal that the plasmodesmata in the root meristem carry a substantial flux of small molecules and that this flux is subject to rapid regulation.
Switching angle optimization based Genetic algorithms for harmonic reduction in three-phase PWM inverters

A simple but powerful design method based on real-coded Genetic algorithms (GAs) to solve the minimization of the Total Harmonic Distortion (THD) criterion is obtained. GAs provides a much simpler approach to off-line tuning of Pulse width Modulation (PWM) switching angles than the rather complicated non-genetic optimization algorithms. Genetic algorithms are exploratory search and optimization procedures that were devised on the principles of natural evolution and population genetics.
Response of Tundra Ecosystem in Southwestern Alaska to Younger-dryas Climatic Oscillation

Climatic warming during the last glacial±interglacial transition (LGIT) was punctuated by reversals to glacial-like conditions. Palaeorecords of ecosystem change can help document the geographical extent of these events and improve our understanding of biotic sensitivity to climatic forcing. To reconstruct ecosystem and climatic variations during the LGIT, we analyzed lake sediments from southwestern Alaska for fossil pollen assemblages, biogenic-silica content (BSiO 2 %), and organic-carbon content (OC%). Betula shrub tundra replaced herb tundra as the dominant vegetation of the region around 13 600 cal BP (cal BP: 14 C calibrated calendar years before present), as inferred from an increase of Betula pollen percentages from < 5% to > 20% with associated decreases in Cyperaceae, Poaceae, and Artemisia. At c. 13 000 cal BP, a decrease of Betula pollen from 28 to < 5% suggests that shrub tundra reverted to herb tundra. Shrub tundra replaced herb tundra to resume as the dominant vegetation at 11 600 cal BP. Higher OC% and BSiO 2 % values suggest more stable soils and higher aquatic productivity during shrub-tundra periods than during herb-tundra periods, although pollen changes lagged behind changes in the biogeochemical indicators before c. 13 000 cal BP. Comparison of our palaeoecological data with the ice-core d 18 O record from Greenland reveals strikingly similar patterns from the onset through the termination of the Younger Dryas (YD). This similarity supports the hypothesis that, as in the North Atlantic region, pronounced YD climatic oscillations occurred in the North Pacific region. The rapidity and magnitude of ecological changes at the termination of the YD are consistent with greenhouse experiments and historic photographs demonstrating tundra sensitivity to climatic forcing.
High-resolution X-ray imaging and spectroscopy of the core of NGC 4945 with XMM-Newton and Chandra

We utilize the complementary capabilities of XMM-Newton and Chandra to conduct a detailed imaging and spectral study of the nearby galaxy NGC 4945 focusing on its nucleus and immediate surroundings (within ∼1 kpc of the nucleus). A complex morphology is revealed including a predominantly hard, but partially resolved, nuclear source plus a spectrally soft, conically shaped X-ray 'plume', which extends 30 arcsec (500 pc) to the north-west. In NGC 4945 our direct view of the active galactic nucleus (AGN) is blocked below ∼10 keV by extremely heavy line-of-sight absorption, and the observed X-ray spectrum is dominated by multi-temperature thermal emission associated with the nuclear starburst and the X-ray plume. Nevertheless the signature of the AGN is present in the form of a neutral Compton reflection component and a 6.4 keV fluorescent iron Kα line. We conjecture that the site of the continuum reprocessing is the far wall of a highly inclined molecular torus, a geometry which is consistent with the presence of H 2 O megamaser emission in this source. The soft spectrum (∼0.6 keV) and limb-brightened appearance of the X-ray plume suggest an interpretation in terms of a mass-loaded superwind emanating from the nuclear starburst.
Two studies on the language behavior of schizophrenics.

Chapman's hypothesis that contextual constraints are less salient and stronger meaning constraints more salient for schizophrenics than for normals was tested, as was the hypothesis drawn from the work of Salzinger and of Cromwell and Dokecki that schizophrenics are overly constrained by immediate cues relative to distant ones. The Chapman hypothesis was supported only for disorganized schizophrenics and only when the ambiguous element being considered is lexical. The immediacy hypothesis was supported with regard to semantic constraints.
Designing for Citizen Data Analysis: A Cross-Sectional Case Study of a Multi-Domain Citizen Science Platform

Designing an effective and sustainable citizen science (CS)project requires consideration of a great number of factors. This makes the overall process unpredictable, even when a sound, user-centred design approach is followed by an experienced team of UX designers. Moreover, when such systems are deployed, the complexity of the resulting interactions challenges any attempt to generalisation from retrospective analysis. In this paper, we present a case study of the largest single platform of citizen driven data analysis projects to date, the Zooniverse. By eliciting, through structured reflection, experiences of core members of its design team, our grounded analysis yielded four sets of themes, focusing on Task Specificity, Community Development, Task Design and Public Relations and Engagement, supported by two-to-four specific design claims each. For each, we propose a set of design claims (DCs), drawing comparisons to the literature on crowdsourcing and online communities to contextualise our findings.
Indole-3-Carbinol Synergizes with and Restores Fludarabine Sensitivity in Chronic Lymphocytic Leukemia Cells Irrespective of p53 Activity and Treatment Resistances

Purpose: Chronic lymphocytic leukemia (CLL) still is lacking a cure. Relapse and development of refractoriness to current treatments are common. New therapies are needed to improve patient prognosis and survival. Experimental design: Indole-3-carbinol (I3C) is a natural product with antitumor properties already clinically tested. The effect of I3C, F-ara-A, and combinations of both drugs on CLL cells from patients representing different Rai stages, IGHV mutation status, cytogenetic alterations, p53 functionality, and treatment resistances was tested, as well as the toxicity of these treatments in mice. Results: I3C induces cytotoxicity in CLL cells but not in normal lymphocytes. I3C strongly synergized with F-ara-A in all CLL cells tested, including those with p53 deficiency and/or F-ara-A resistance. The mechanism of cell death involved p53-dependent and -independent apoptosis. The combination of I3C + F-ara-A was equally effective in CLL cells irrespective of IGHV mutation stage and patient refractoriness. Moreover, CLL survival and treatment resistance induced by co-culturing CLL cells on stroma cells were overcome by the combinatory I3C + F-ara-A treatment. No toxicity was associated with the combined I3C + fludarabine treatment in mice. Conclusions: I3C in combination with F-ara-A is highly cytotoxic in CLL cells from refractory patients and those with p53 deficiency. The striking dose reduction index for F-ara-A in combination with I3C would reduce fludarabine toxicity while having a similar or better anti-CLL effectiveness. Moreover, the low toxicity of I3C, already clinically tested, supports its use as adjuvant and combinatory therapy in CLL, particularly for patients with relapsed or refractory disease. Clin Cancer Res; 22(1); 134–45. ©2015 AACR.
Perivitelline space granularity: a sign of human menopausal gonadotrophin overdose in intracytoplasmic sperm injection.

The significance of the presence of coarse dark granules in the perivitelline space of oocytes has not been studied before. The study included 2288 intact oocytes [2063 in metaphase II (MII), 136 in metaphase I (MI), and 89 in germinal vesicle (GV)] retrieved in 206 intracytoplasmic sperm injection cycles stimulated by a long agonist protocol. The incidence of granules varied with oocyte maturity. It was detected in 34.3% and 4% of the MII and MI oocytes respectively, while none of the GV oocytes contained granules. The woman's age, hormonal values (oestradiol and progesterone), human chorionic gonadotrophin/oocyte retrieval interval, number of oocytes retrieved, and oocyte retrieval/injection interval were not related to the percentage of granular oocytes. Moreover, there was no correlation between the percentage of granular oocytes and the fertilization and cleavage rates, pregnancy outcome, as well as the implantation rate. Patients were divided into three groups according to the total human menopausal gonadotrophin (HMG) dose they received. There was a statistically significant difference between the three groups in the percentage of granular oocytes [17.4 +/- 5.2% versus 26.7 +/- 3.2% versus 45.4 +/- 4.2% in the low-dose (< 30 ampoules), intermediate dose (31-45 ampoules), and high-dose (> 45 ampoules) groups respectively]. We conclude that granularity in the perivitelline space is probably a physiological phenomenon related to the maturational events in oocytes and enhanced by exposure to high dosages of HMG.
Dynamic Vibrotactile Signals for Forward Collision Avoidance Warning Systems

Objective: Four experiments were conducted in order to assess the effectiveness of dynamic vibrotactile collision-warning signals in potentially enhancing safe driving. Background: Auditory neuroscience research has demonstrated that auditory signals that move toward a person are more salient than those that move away. If this looming effect were found to extend to the tactile modality, then it could be utilized in the context of in-car warning signal design. Method: The effectiveness of various vibrotactile warning signals was assessed using a simulated car-following task. The vibrotactile warning signals consisted of dynamic toward-/away-from-torso cues (Experiment 1), dynamic versus static vibrotactile cues (Experiment 2), looming-intensity- and constant-intensity-toward-torso cues (Experiment 3), and static cues presented on the hands or on the waist, having either a low or high vibration intensity (Experiment 4). Results: Braking reaction times (BRTs) were significantly faster for toward-torso as compared to away-from-torso cues (Experiments 1 and 2) and static cues (Experiment 2). This difference could not have been attributed to differential responses to signals delivered to different body parts (i.e., the waist vs. hands; Experiment 4). Embedding a looming-intensity signal into the toward-torso signal did not result in any additional BRT benefits (Experiment 3). Conclusion: Dynamic vibrotactile cues that feel as though they are approaching the torso can be used to communicate information concerning external events, resulting in a significantly faster reaction time to potential collisions. Application: Dynamic vibrotactile warning signals that move toward the body offer great potential for the design of future in-car collision-warning system.