Miracle-dz/UniFAR-FTUs huggingface dataset:
Serotype 5 Pneumococci Causing Invasive Pneumococcal Disease Outbreaks in Barcelona, Spain (1997 to 2011)

ABSTRACT In this study, we analyzed the clinical and molecular epidemiology of invasive serotype 5 (Ser5) pneumococcal isolates in four teaching hospitals in the Barcelona, Spain, area (from 1997 to 2011). Among 5,093 invasive pneumococcal isolates collected, 134 (2.6%) Ser5 isolates were detected. Although the overall incidence of Ser5-related invasive pneumococcal disease (IPD) was low (0.25 cases/100,000 inhabitants), three incidence peaks were detected: 0.63/100,000 in 1999, 1.15/100,000 in 2005, and 0.37/100,000 in 2009. The rates of Ser5 IPD were higher among young adults (18 to 64 years old) and older adults (>64 years old) in the first two peaks, whereas they were higher among children in 2009. The majority (88.8%) of the patients presented with pneumonia. Comorbid conditions were present in young adults (47.6%) and older adults (78.7%), the most common comorbid conditions being chronic obstructive pulmonary disease (20.6% and 38.3%, respectively) and cardiovascular diseases (11.1% and 38.3%, respectively). The mortality rates were higher among older adults (8.5%). All Ser5 pneumococci tested were fully susceptible to penicillin, cefotaxime, erythromycin, and ciprofloxacin. The resistance rates were 48.5% for co-trimoxazole, 6.7% for chloramphenicol, and 6% for tetracycline. Two major related sequence types (STs), ST1223 (n = 65) and ST289 (n = 61), were detected. The Colombia5-ST289 clone was responsible for all the cases in the Ser5 outbreak in 1999, whereas the ST1223 clone accounted for 73.8% and 61.5% of the isolates in 2005 and 2009, respectively. Ser5 pneumococci are a frequent cause of IPD outbreaks in the community and involve children and adults with or without comorbidities. The implementation of the new pneumococcal conjugated vaccines (PCV10 and PCV13) might prevent such outbreaks.
The Effect of Radioiodine on the Intima Media Thickness of the Carotid Artery

Aim: The radiation can induce vessel injury. The result of this injury can be severe and life-threatening. There are a few studies demonstrating an increase in intima-media thickness (IMT) of the common carotid artery (CCA) after radiotherapy, especially in head and neck cancers. We evaluated the effect of I-131 to the IMT of the CCA in the patients who were treated for hyperthyroidism. Methods: 38 patients (25M, 13W) referred to our department for radioiodine treatment with the diagnosis of nodular goitre (25 patients) and diffuse hyperplasia (Graves disease (GD), 13 patients) were included to the prospective study. An USG was performed for all the patients before therapy, 3, 6 and 12 months after radioiodine therapy in order to measure IMT of CCA and the femoral artery (FA). The IMT was measured at the level of proximal part of bulbus anteriorly on the left and right side. The IMT of FA was measured just before the bifurcation. Results: There was a statistically significant increase in IMT of both CCA and FA bilaterally in nodular hyperthyroid patients. However, in the patients with Graves disease, there was only statistically significant increase in the left IMT of CCA at 0-3rd, 0-6th month measurements and in the right IMT of FA at 0-3rd month measurements. Conclusion: Though the limitation of the study is the interobserver and intraobserver variability, it was seen that I-131 therapy might affect the IMT of CCA in the patients with NG. I-131 effect on the IMT of CCA in patients with nodular goitre was higher than the IMT of CCA in patients with GD. I-131 effect on the IMT of CCA might be due to administered dose and adjacency. The interesting point of our study was the increased thickness of IMT in FA. We think that the increase in IMT is due to the systemic effect of radioactivity circulating in the blood vessel. I-131 effect on the IMT of FA in patients with nodular goitre was higher than the IMT of FA in the patients with GD due to I-131 uptake of thyroid gland. Because I-131 uptake was lower in patients with nodular goitre, I-131 in systemic circulation was higher. Conflict of interest:None declared.
Differential bud activation by a net positive root signal explains branching phenotype in prostrate clonal herbs: a model

Regulation of branching within perennial prostrate clonal herbs differs from the annual orthotropic species, Arabidopsis and pea, as the dominant signal transported from roots is a branching promoter, not an inhibitor. Trifolium repens, an exemplar of such prostrate species, was used to investigate the interaction between roots and branch development. This study tests whether or not current knowledge when synthesized into a predictive model is sufficient to simulate the branching pattern developing on the shoot distal to a basal root. The major concepts underpinning the model are: (i) bud outgrowth (activation) is stimulated in a dose-dependent manner by branching promoter signals from roots, (ii) the distribution of this net root stimulus (NRS) is uniform throughout the shoot system distal to the basal root but declines geometrically in intensity upon continued enlargement of this shoot system, and (iii) each bud has an outgrowth potential, equal to the activation level of the apical bud in which it forms, that moderates its response to NRS. The validity of these concepts was further tested by running simulations of the branching of a phylogenetically-distanced prostrate perennial monocotyledonous species, Tradescantia fluminensis. For both species the model reasonably accounted for the observed pattern of branching. The outgrowth potential of buds plays an important role in limiting the number of hierarchies of branching that can develop on a plant. In conclusion, for both species, the model accounted for the major factors involved in the correlative regulation of branching and is possibly also pertinent for all prostrate clonal species.
Measuring Social Support in Battered Women

Social support is related to mental health outcomes among battered women. It is unclear, however, whether researchers should measure social support as a unidimensional or multidimensional concept. Efforts to identify the latent dimensions underlying a common measure of social support, the Interpersonal Support Evaluation List (ISEL), have yielded inconsistent results. This study used exploratory factor analytic procedures to determine the most appropriate factor structure for the ISEL. The ISEL was completed by two samples (one help seeking, one non–help seeking) of primarily African American, low-income battered women who had experienced intimate partner violence (IPV) within the previous year. Results indicated that social support in battered women is best conceptualized as unidimensional.
Shape optimization for a sharp interface model of distortion compensation

A mechanical equilibrium problem for a material consisting of two components with different densities is considered. Due to the heterogeneous material densities, the outer shape of the underlying workpiece can be changed by shifting the interface between the subdomains. In this paper, the problem is modeled as a shape design problem for optimally compensating unwanted workpiece changes. The associated control variable is the interface. Regularity results for transmission problems are employed for a rigorous derivation of suitable first-order optimality conditions based on the speed method. The paper concludes with several numerical results based on a spline approximation of the interface.
CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial.

BACKGROUND Adjuvant tamoxifen therapy is effective for postmenopausal women with endocrine-responsive breast cancer. Cytochrome P450 2D6 (CYP2D6) enzyme metabolizes tamoxifen to clinically active metabolites, and CYP2D6 polymorphisms may adversely affect tamoxifen efficacy. In this study, we investigated the clinical relevance of CYP2D6 polymorphisms. METHODS We obtained tumor tissues and isolated DNA from 4861 of 8010 postmenopausal women with hormone receptor-positive breast cancer who enrolled in the randomized, phase III double-blind Breast International Group (BIG) 1-98 trial between March 1998 and May 2003 and received tamoxifen and/or letrozole treatment. Extracted DNA was used for genotyping nine CYP2D6 single-nucleotide polymorphisms using polymerase chain reaction-based methods. Genotype combinations were used to categorize CYP2D6 metabolism phenotypes as poor, intermediate, and extensive metabolizers (PM, IM, and EM, respectively; n = 4393 patients). Associations of CYP2D6 metabolism phenotypes with breast cancer-free interval (referred to as recurrence) and treatment-induced hot flushes according to randomized endocrine treatment and previous chemotherapy were assessed. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. RESULTS No association between CYP2D6 metabolism phenotypes and breast cancer-free interval was observed among patients who received tamoxifen monotherapy without previous chemotherapy (P = .35). PM or IM phenotype had a non-statistically significantly reduced risk of breast cancer recurrence compared with EM phenotype (PM or IM vs EM, HR of recurrence = 0.86, 95% CI = 0.60 to 1.24). CYP2D6 metabolism phenotype was associated with tamoxifen-induced hot flushes (P = .020). Both PM and IM phenotypes had an increased risk of tamoxifen-induced hot flushes compared with EM phenotype (PM vs EM, HR of hot flushes = 1.24, 95% CI = 0.96 to 1.59; IM vs EM, HR of hot flushes = 1.23, 95% CI = 1.05 to 1.43). CONCLUSIONS CYP2D6 phenotypes of reduced enzyme activity were not associated with worse disease control but were associated with increased hot flushes, contrary to the hypothesis. The results of this study do not support using the presence or absence of hot flushes or the pharmacogenetic testing of CYP2D6 to determine whether to treat postmenopausal breast cancer patients with tamoxifen.
Empirically assessing the continued applicability of the IUIPC construct

– The purpose of this paper is to revisit the internet users’ information privacy concerns (IUIPC) construct, a research model, and hypotheses based on Malhotra et al. (2004) to assess the continued applicability of this construct. The relationship among privacy concerns, trusting beliefs, and risk beliefs continues to be unclear. Empirical evidence about the impact of privacy concerns on behavior is mixed. , – A paper-based questionnaire was distributed and collected from 63 part-time graduate students of a private university in the mid-Atlantic USA. These respondents have an average of six years of full-time professional work experience and the vast majority (88.9 percent) has over seven years of experience on the internet. Questionnaire items measured the constructs of the IUIPC instrument. All measurement scales were validated using factor analysis, Cronbach's α, and reliability analysis. For hypothesis testing, multiple regression analysis was used. , – The results partially support those of Malhotra et al. (2004). Consistent are the findings that the higher the trust a consumer holds for an online company, the less likely that consumer is to view providing personal information as risky. Also consistent is that the higher the trust a consumer holds for an online company, the more likely is that consumer to intend to provide personal information online. Finally, the greater risk a consumer has for providing personal information, the less willing that consumer is to reveal such information online. However, the results did not support a negative relationship between the IUIPC construct and consumer trust in an online company or a positive relationship between IUIPC and consumer risk in providing personal information to an online company. The paper concludes that the IUIPC is not the valid scale to employ in measuring information privacy concerns. , – The main limitation of the findings is the use of a small convenience sample, limiting the insights into interrelationships between various dimensions of privacy concerns and the generalizability of the results. , – The results may provide guidance to online retailers in addressing the dimensions of privacy concerns related to trusting beliefs and risk beliefs. , – IUIPC were measured using the IUIPC instrument. This responds to Malhotra et al.'s (2004) call to use the IUIPC scale and the associated research framework to further investigate consumer privacy concerns and the suggestion by Belanger and Crossler (2011) that more studies should explore this scale. Further, both Westin (1967), and Smith et al. (1996) recognize that privacy attitudes and concerns may change over time, providing motivation to revisit IUIPC.
Molecular characterization of atoxigenic strains for biological control of aflatoxins in Nigeria

Aflatoxins are highly toxic carcinogens produced by several species in Aspergillus section Flavi. Strains of A. flavus that do not produce aflatoxins, called atoxigenic strains, have been used commercially in North America as tools for limiting aflatoxin contamination. A similar aflatoxin management strategy is being pursued in Nigeria. In the current study, loci across the 68 kb aflatoxin biosynthesis gene cluster were compared among 18 atoxigenic and two aflatoxin-producing vegetative compatibility groups (VCGs) from Nigeria and an atoxigenic VCG used commercially in North America. Five of the atoxigenic VCGs had large deletions (37–65 kb) extending from the teleomeric side of the aflatoxin biosynthesis cluster. In one VCG (AV0222) the deletion extended through the cluster to the adjacent sugar cluster. The remaining twelve atoxigenic VCGs, including the VCG used for aflatoxin management in North America, contained all the aflatoxin pathway genes, but with defects. Two observations support the long-term persistence of atoxigenicity within A. flavus: first, a comparison of pathway genes revealed more changes in atoxigenic than in aflatoxin-producing isolates relative to the aflatoxin-producing strain NRRL 3357; and second, several non-synonymous changes are unique to atoxigenics. Atoxigenic VCG diversity was assessed with phylogenetic analyses. Although some atoxigenics share relatively recent ancestry, several are more closely related to aflatoxin producers than to other atoxigenics. The current study demonstrates VCGs of A. flavus in West Africa with diverse mechanisms of atoxigenicity and potential value in aflatoxin management programmes.
Partial body weight support with treadmill locomotion to improve gait after incomplete spinal cord injury: a single-subject experimental design.

BACKGROUND AND PURPOSE Gait training with partial body weight support has been used to improve gait. In this study, changes in gait relative to speed, cadence, stride length, and percentages of stance and swing for both lower extremities (LEs) during comfortable walking, fast walking, and running were studied in a subject with an incomplete C-5 on C-6 spinal cord injury. SUBJECT AND METHODS A single-subject experimental design was used. Following a 6-week period of baseline measurements taken at various intervals (phase AI), the subject ambulated on a treadmill three times a week for 6 weeks with 32% of his body weight supported (phase B). Phase B was followed by a 3-week period without treatment during which measurements were taken at various intervals (phase AII). Gait variables were measured once a week during comfortable walking, fast walking, and running. Heart rate was monitored during treadmill training. RESULTS During comfortable walking, fast walking, and running, improvements were seen in gait speed. During running, improvements also were seen in stride length and percentages of stance and swing for the right LE. The largest changes were recorded during running. Smaller changes were recorded during comfortable walking and fast walking. CONCLUSION AND DISCUSSION These results justify testing the efficacy of this technique with larger groups of subjects with neurological impairments.
Contribution of hepatitis B virus X protein-induced aberrant microRNA expression to hepatocellular carcinoma pathogenesis

The hepatitis B virus-encoded X (HBX) protein plays important roles in Hepatocellular carcinoma (HCC). Previous studies have demonstrated that HBX can induce alterations in the expression of numerous microRNAs (miRNAs) involved in the carcinogenesis of various tumors. However, the global profile of liver miRNA changes induced by HBX has not been characterized. In this study, we conducted a miRNA microarray analysis to investigate the influence of HBX on the expression of total miRNAs in liver in relation to HCC. Comparative analysis of the data from human normal liver cells (L02) and human HCC cells (HepG2), with or without HBX, identified 19 differentially expressed miRNAs, including 5 with known association to HBX. Target gene prediction for the aberrantly expressed miRNAs identified a total of 304 potential target genes, involved in sundry pathways. Finally, pathway analysis of the HBXinduced miRNAs pathway showed that 5 of the total miRNAs formed an internetwork, suggesting that HBX might exert its pathological effects on hepatic cells through functional synergy with miRNAs that regulated common pathways in liver cells. Therefore, this work provides new insights into the mechanisms of HCC as well as potential diagnostic markers or therapeutic targets for use in clinical management of HCC.
A survey and evaluation of promising approaches for automatic image-based defect detection of bridge structures

Automatic health monitoring and maintenance of civil infrastructure systems is a challenging area of research. Nondestructive evaluation techniques, such as digital image processing, are innovative approaches for structural health monitoring. Current structure inspection standards require an inspector to travel to the structure site and visually assess the structure conditions. A less time consuming and inexpensive alternative to current monitoring methods is to use a robotic system that could inspect structures more frequently. Among several possible techniques is the use of optical instrumentation (e.g. digital cameras) that relies on image processing. The feasibility of using image processing techniques to detect deterioration in structures has been acknowledged by leading experts in the field. A survey and evaluation of relevant studies that appear promising and practical for this purpose is presented in this study. Several image processing techniques, including enhancement, noise removal, registration, edge detection, line detection, morphological functions, colour analysis, texture detection, wavelet transform, segmentation, clustering and pattern recognition, are key pieces that could be merged to solve this problem. Missing or deformed structural members, cracks and corrosion are main deterioration measures that are found in structures, and they are the main examples of structural deterioration considered here. This paper provides a survey and an evaluation of some of the promising vision-based approaches for automatic detection of missing (deformed) structural members, cracks and corrosion in civil infrastructure systems. Several examples (based on laboratory studies by the authors) are presented in the paper to illustrate the utility, as well as the limitations, of the leading approaches.
Odontogenic myxoma of the maxilla: A report of a rare case and review of the literature

Odontogenic myxoma represents an uncommon benign neoplasm comprising of 3–6% of all odontogenic tumors. This article presents a rare case of odontogenic myxoma occurring in the maxilla of a 7-year-old male patient with a brief review of the pathogenesis, clinical, radiological, histopathological, ultrastructural and immunohistochemical characteristics of odontogenic myxoma.
Predictors of quality-of-life improvement following pulmonary resection due to lung cancer.

CONTEXT AND OBJECTIVE There is increasing involvement of health professionals in organizing protocols to determine the impact of lung surgery on functional state and activities of daily living, with the aim of improving quality of life (QoL). The objective of this study was to investigate predictors of QoL improvement among patients undergoing parenchyma resection due to lung cancer. DESIGN AND SETTING Prospective study, at teaching hospital of Universidade Estadual de Campinas (Unicamp). METHODS 36 patients with lung cancer diagnosis were assessed before surgery and on the 30th, 90th and 180th days after surgery. The Short-Form Health Survey (SF-36) was used as the dependent variable. The independent variables were the Hospital Anxiety and Depression (HAD) scale, a six-minute walking test (6-MWT), a visual analogue scale for pain, forced vital capacity (FVC), type of surgery and use of radiotherapy and chemotherapy. Generalized estimation equations (GEE) were utilized. RESULTS The median age for these 20 men and 16 women was 55.5 +/- 13.4 years. Both FVC and 6-MWT were predictors of improvement in the physical dimensions of QoL (p = 0.011 and 0.0003, respectively), as was smaller extent of surgical resection (p = 0.04). The social component of QoL had improved by the third postoperative month (p = 0.0005). CONCLUSION The predictors that affected QoL positively were better FVC and 6-MWT results and less extensive lung resection. Three months after the surgery, an improvement in social life was already seen.