Miracle-dz/UniFAR-FTUs huggingface dataset:
The principle of synthesizing HRRP based on a new OFDM phase-coded stepped-frequency radar signal

Orthogonal Frequency-Division Multiplexing (OFDM) phase-coded pulse is a wideband signal, of which the range resolution is inversely proportional to the bandwidth. However, it is a challenge to synthesize large bandwidth for OFDM phase-coded pulse since wide instantaneous bandwidth and high sampling rate requirements. To solve this problem, this paper proposes a new radar signal called OFDM phase-coded stepped-frequency (OFDM-PCSF) signal, of which the pulse train is stepped frequency, and each pulse is implemented with OFDM phase-coded chips. The property of OFDM-PCSF signal is analyzed at first. And then, the mathematical expressions of the high resolution range profiles (HRRP) are derived, assuming an elementary scenario of point-scattering targets. It mainly presents the influence of velocity on HRRP and investigates the parameter design and velocity compensation, which is helpful for the realization of OFDM imaging radar. Finally, the simulation results demonstrate the validity of the conclusions.
In vitro cytotoxicity and hemocompatibility studies of Ti-Nb, Ti-Nb-Zr and Ti-Nb-Hf biomedical shape memory alloys

The in vitro cytotoxicity and hemocompatibility of the Ti-Nb, Ti-Nb-Zr and Ti-Nb-Hf biomedical shape memory alloys (SMAs) were investigated by cell culture (L-929 fibroblast cell), hemolytic test and platelet adhesion test, with CP Ti as a reference material. The cytotoxicity test indicates that all the Ti-Nb, Ti-Nb-Zr and Ti-Nb-Hf SMAs show over 94% cell viability for different incubation times (2, 4 and 7 days) in comparison with a negative control and CP Ti. The cell morphology observation shows good polygon-like adherent growth and proliferation of L-929 in the extracts of all the test samples and CP Ti. These results suggest excellent cytocompatibility for the Ti-Nb, Ti-Nb-Zr and Ti-Nb-Hf SMAs. The hemolytic test reveals that the hemolysis ratios of the Ti-Nb, Ti-Nb-Zr and Ti-Nb-Hf alloys are far less than 5%, so they cannot give rise to acute hemolysis. The platelet morphology observation shows almost the same adhered platelet morphology and activation ratio for the test samples in comparison with CP Ti, except the Ti-22Nb-6Hf alloy, which shows a lower activation ratio of platelets, indicating excellent blood compatibility. Therefore, it is proposed that the Ti-Nb, Ti-Nb-Zr and Ti-Nb-Hf SMAs will be candidates to replace Ti-Ni for biomedical applications.
Posterior Hip Dislocation with Ipsilateral Femoral Head and Shaft Fracture - Using a Temporary External Fixator as a Method for Closed Reduction

Introduction: Complex fractures are increasing because of various traumatic mechanisms. They drift from standard classifications, and their treatment is controversial. Of such cases are hip dislocations with associated fractures of the ipsilateral femur. Case Report: This case report describes the condition of a 30-year-old man involved in a motor vehicle collision. Clinical examination, X-rays, and computed tomography scan revealed a posterior hip dislocation with an ipsilateral femoral head and mid-shaft fractures. The patient was treated by closed reduction of hip dislocation using a temporarily applied external fixator followed by intramedullary nailing of the femoral shaft. Achieving a closed reduction is a challenge with ipsilateral fractures but it should be favored over open reduction due to a lower risk of complications. The type of femoral head fracture, in this case, may have aided in an easier reduction. Conclusion: Hip dislocation is an orthopedic emergency and its treatment is challenging if associated with ipsilateral fractures. The decision of a closed versus an open approach should be made after considering the management plans of other injuries.
Deprivation linked to malnutrition risk and mortality in hospital

This study aimed to investigate the link between deprivation and in-hospital malnutrition and to assess any independent and interrelated effects of deprivation and malnutrition on clinical outcome in hospital. One thousand patients (mean age 71 (sd 19) years, mean BMI 25·6 (sd 5·4) kg/m2) were screened for malnutrition (using the Malnutrition Universal Screening Tool (‘MUST’)) and their clinical outcome assessed prospectively. The deprivation of patients' locality of residence prior to admission was recorded using the Index of Multiple Deprivation 2000 (IMD). Patients with medium and high malnutrition risk (42 %, n 420) were admitted from areas with significantly greater deprivation (lower ranks) than low-risk patients (IMD 3731 v. 3946; P<0·02). The prevalence of malnutrition increased by multiples of 1·14 (95 % CI 1·02, 1·28) for each increment in quartile of IMD rank. The odds of malnutrition of the most deprived quartile were greater than those of the least deprived quartile by a factor of 1·59 (95 % CI 1·11, 2·28). They were also greater for five of the six components of IMD deprivation (and by a factor of 1·73 (95 % CI 1·20, 2·49) for income and 1·69 (95 % CI 1·18, 2·42) for employment). Greater in-hospital mortality was associated with malnutrition, independently of IMD (or its individual components; odds ratio 2·04 (95 % CI 1·22, 3·44)). Length of stay was associated only with malnutrition risk (P<0·0005). This study highlights that in-hospital malnutrition and deprivation are interrelated, yet have independent, adverse associations with patient outcome. Effective strategies are required to tackle these common health inequalities in both clinical and public health settings.
Study of AC Pollution Flashover Performance of Porcelain Insulators at High Altitude Sites of 2800  $\sim$ 4500 m

The external insulation of electric equipments will be affected by the atmospheric conditions in the high altitude regions. However, a few investigations at the high altitude sites of 3000 m and above have been conducted. This paper reports on the laboratory tests of artificially polluted cap-and-pin porcelain insulators performed at the high altitudes of 2800 m to 4500 m. The test results and analysis show that the pollution flashover voltages in high altitude regions are affected not only by the pollution grades but also by the atmospheric parameters. The exponent characterizing the influence of equivalent salt deposit density is 0.26 to 0.29 and the one characterizing the influence of nonsoluble deposit density is 0.09 to 0.15. The ac pollution flashover voltage U f will decrease with the decrease of air pressure P and increase with the decrease of ambient temperature t . U f is a power function of the ration of air pressure P/P 0 and also is a power function of the ambient temperature coefficient (1 + 0.02(t - 20)). The average exponent characterizing the influence of air pressure is about 0.56 and the exponent characterizing the influence of ambient temperature is about 0.21 for the three types of insulators in the paper.
The cost-effectiveness of diagnostic testing strategies for Helicobacter pylori

OBJECTIVE:Several noninvasive methods are now available for diagnosing Helicobacter pylori infection. Because the prevalence of H. pylori infection is variable in patients requiring testing, the optimal testing strategies may vary under different conditions. The aim of this study was to evaluate the cost-effectiveness of competing diagnostic strategies for H. pylori in patients with varying H. pylori prevalence.METHODS:A decision analysis was performed comparing the costs per number of correct diagnoses achieved by alternative sequential testing strategies. Estimates of H. pylori prevalence and test characteristics were derived from a systematic review of the MEDLINE bibliographic database. Cost estimates were derived from the 2000 Medicare Fee Schedule.RESULTS:The enzyme-linked immunosorbent assay (ELISA) test had the lowest cost per correct diagnosis at low (30%), intermediate (60%), and high (90%) prevalence ($90–$95/correct diagnosis), but its diagnostic accuracy was low (80–84%). At low and intermediate prevalence the stool test was more accurate (93%), with an average cost of $126–$127 per correct diagnosis. Additional confirmatory testing of positive or negative tests increased the diagnostic accuracy of the stool test, but had high incremental costs. ELISA testing was preferable when prevalence rates were very high (90%), and using a confirmatory urea breath test for negative ELISA tests increased the diagnostic accuracy to 96%, with modest incremental costs. If the cost of the breath test was <$50 or if the cost of the stool test is >$82, breath testing became preferable to stool testing. If the cost of the stool test fell to <$20, it became preferable to ELISA. Similarly, if the cost of the ELISA serology was >$39 then stool testing became preferable at all prevalence rates. Fingerstick whole blood tests were not cost-effective.CONCLUSIONS:The choice of an initial test for H. pylori detection depends on the prevalence of H. pylori infection and the value placed on increased diagnostic accuracy. Although ELISA results in the lowest cost-effectiveness ratios, in patients at low-intermediate pretest probability of infection, the stool test provides increased accuracy, with modest incremental costs.
Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post‐Hoc Analysis of the GISSI‐HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca‐Heart Failure) Trial

Background The independent prognostic impact of diabetes mellitus (DM) and prediabetes mellitus (pre‐DM) on survival outcomes in patients with chronic heart failure has been investigated in observational registries and randomized, clinical trials, but the results have been often inconclusive or conflicting. We examined the independent prognostic impact of DM and pre‐DM on survival outcomes in the GISSI‐HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca‐Heart Failure) trial. Methods and Results We assessed the risk of all‐cause death and the composite of all‐cause death or cardiovascular hospitalization over a median follow‐up period of 3.9 years among the 6935 chronic heart failure participants of the GISSI‐HF trial, who were stratified by presence of DM (n=2852), pre‐DM (n=2013), and non‐DM (n=2070) at baseline. Compared with non‐DM patients, those with DM had remarkably higher incidence rates of all‐cause death (34.5% versus 24.6%) and the composite end point (63.6% versus 54.7%). Conversely, both event rates were similar between non‐DM patients and those with pre‐DM. Cox regression analysis showed that DM, but not pre‐DM, was associated with an increased risk of all‐cause death (adjusted hazard ratio, 1.43; 95% CI, 1.28–1.60) and of the composite end point (adjusted hazard ratio, 1.23; 95% CI, 1.13–1.32), independently of established risk factors. In the DM subgroup, higher hemoglobin A1c was also independently associated with increased risk of both study outcomes (all‐cause death: adjusted hazard ratio, 1.21; 95% CI, 1.02–1.43; and composite end point: adjusted hazard ratio, 1.14; 95% CI, 1.01–1.29, respectively). Conclusions Presence of DM was independently associated with poor long‐term survival outcomes in patients with chronic heart failure. Clinical Trial Registration URL: http://www.clinicaltrials. gov. Unique identifier: NCT00336336.
Effects of acute exposure to bifenthrin on some haematological, biochemical and histopathological parameters of rainbow trout (Oncorhynchus mykiss).

Abstr Act : The effect of the pyrethroid, bifenthrin, on rainbow trout (Oncorhynchus mykiss) was assessed based on biochemical, haematological and histopathological examination of fish exposed to Talstar 10 EC pes ticide preparation (active substance 100 g/l bifenthrin) at a concentration of 14.7 µg/l. There was a significant (P < 0.01) decrease in plasma ammonia, and significant (P < 0.01) increase in glucose, creatine kinase, alkaline phosphatase and lactate dehydrogenase. Haematologically, fish showed a significant (P < 0.01) decrease in mean erythrocyte volume, erythrocyte haemoglobin, and band neutrophil granulocytes compared to controls. Degeneration of hepatocytes was observed histologically. The bifenthrin-based Talstar 10 EC pesticide preparation was therefore classified as a substance strongly toxic to fish.
Deep Reinforcement Learning for Dialogue Generation

Recent neural models of dialogue generation offer great promise for generating responses for conversational agents, but tend to be shortsighted, predicting utterances one at a time while ignoring their influence on future outcomes. Modeling the future direction of a dialogue is crucial to generating coherent, interesting dialogues, a need which led traditional NLP models of dialogue to draw on reinforcement learning. In this paper, we show how to integrate these goals, applying deep reinforcement learning to model future reward in chatbot dialogue. The model simulates dialogues between two virtual agents, using policy gradient methods to reward sequences that display three useful conversational properties: informativity (non-repetitive turns), coherence, and ease of answering (related to forward-looking function). We evaluate our model on diversity, length as well as with human judges, showing that the proposed algorithm generates more interactive responses and manages to foster a more sustained conversation in dialogue simulation. This work marks a first step towards learning a neural conversational model based on the long-term success of dialogues.
The Effectiveness of Bilateral Cochlear Implants for Severe-to-Profound Deafness in Adults: A Systematic Review

Objective Assessment of the clinical effectiveness of bilateral cochlear implantation compared with unilateral cochlear implantation or bimodal stimulation, in adults with severe-to-profound hearing loss. In 2007, the National Institute for Health and Clinical Excellence (NICE) in the U.K. conducted a systematic review on cochlear implantation. This study forms an update of the adult part of the NICE review. Data Sources The electronic databases MEDLINE and Embase were searched for English language studies published between October 2006 and March 2011. Study Selection Studies were included that compared bilateral cochlear implantation with unilateral cochlear implantation and/or with bimodal stimulation, in adults with severe-to-profound sensorineural hearing loss. Speech perception in quiet and in noise, sound localization and lateralization, speech production, health-related quality of life, and functional outcomes were analyzed. Data Extraction Data extraction forms were used to describe study characteristics and the level of evidence. Data Synthesis The effect size was calculated to compare different outcome measures. Conclusion Pooling of data was not possible because of the heterogeneity of the studies. As in the NICE review, the level of evidence of the included studies was low, although some of the additional studies showed less risk of bias. All studies showed a significant bilateral benefit in localization over unilateral cochlear implantation. Bilateral cochlear implants were beneficial for speech perception in noise under certain conditions and several self-reported measures. Most speech perception in quiet outcomes did not show a bilateral benefit. The current review provides additional evidence in favor of bilateral cochlear implantation, even in complex listening situations.
Tachycardic Responses During the Development Renal Hypertension

Basal heart rate (HR) of conscious rats under resting conditions was measured daily electrocardiogram (ECG) during the development of one-kidney, one clip (1K1C) hypertension. progressive increase in HR (mean ± SEM) was observed from Day 1 to 7: 318 ± 11; 330 ± 18, 338 18; 344 ± 19; 372 ± 14; 374 ± 11, and 388 ± 12 bpm, respectively. During the same period, mean arterial pressure (MAP) also increase progressively: 126 ± 2; 129 ± 2; 134 ± 4; 135 ± 7; 144 ± 2 and 157 ± 4 mm Hg, respectively. From Day 7 onward, the HR declined, reaching values of 336 ± 13 bpm on Day 9, with no further alterations for the next 21 days. The MAP continued to rise, however, being 158 ± 4 on Day 8 and 175 ± 7 mm Hg on Day 30. Sham-operated rats showed no changes in HR MAP. During the development of hypertension, blockade of converting enzyme with captopril (10 mg/kg, i.v.) caused a significant blood pressure fall on Day 1 (−27 ± 1 mm Hg) and Day 3 (−18 ± 2 Hg), whereas on Day 6 (−9 ± 3 mm Hg) and Day 14 (−8 ± 3 mm Hg) the fall was not different from that of the normotensive control rats (NCR) (−6 ± 1 mm Hg). Reflex bradycardia, produced increasing doses of phenylephrine which elevated the MAP by 10 to 40 mm Hg, was studied conscious NCR and renal hypertensive rats (RHR) 3 and 7 days after surgery during the development of renal hypertension. Impaired baroreflex function was demonstrable on Day 3 for RHR, with sensitivity of 0.425 ± 0.05 vs 0.954 ± 0.11 msec/mm Hg for NCR, but baroreflex function was normal in RHR on the Day 7 (0.932 ± 0.12 msec/mm Hg). Electrical stimulation of the vagus nerve (5 V, msec, 1–128 Hz) under chloralose anesthesia produced bradycardia of the same intensity in NCR and in RHR 3 days after clipping the renal artery, but RHR showed a decreased bradycardia response Day 7. These data show that, during the early development phase of hypertension, rats exhibited transitory tachycardia, which indicated an impaired baroreflex control of the HR.
Element-free Galerkin modeling of giant magnetostrictive thin films

A meshless method called the element-free Galerkin method (EFGM) is introduced into the calculation of magnetostrictive thin film. With the finite element method (FEM), the distortion of the elements will decrease the precision, so EFGM is used to solve this problem. Two different magnetomechanical coupling models are proposed and a thin film cantilever is simulated with these two modeling methods. At last, the results are compared with the experiment data to illustrate the performance of EFGM and the correctness of the models.
Those edibles hit hard ” : Exploration of Twitter data on cannabis dibles in the U . S rancois

Aims: Several states in the U.S. have legalized cannabis for recreational or medical uses. In this context, cannabis edibles have drawn considerable attention after adverse effects were reported. This paper investigates Twitter users’ perceptions concerning edibles and evaluates the association edibles-related tweeting activity and local cannabis legislation. Methods: Tweets were collected between May 1 and July 31, 2015, using Twitter API and filtered through the eDrugTrends/Twitris platform. A random sample of geolocated tweets was manually coded to evaluate Twitter users’ perceptions regarding edibles. Raw state proportions of Twitter users mentioning edibles were ajusted relative to the total number of Twitter users per state. Differences in adjusted proportions of Twitter users mentioning edibles between states with different cannabis legislation status were assesed via a permutation test. Results: We collected 100,182 tweets mentioning cannabis edibles with 26.9% (n = 26,975) containing state-level geolocation. Adjusted percentages of geolocated Twitter users posting about edibles were significantly greater in states that allow recreational and/or medical use of cannabis. The differences were statistically significant. Overall, cannabis edibles were generally positively perceived among Twitter users despite some negative tweets expressing the unreliability of edible consumption linked to variability in effect intensity and duration. Conclusion: Our findings suggest that Twitter data analysis is an important tool for epidemiological monitoring of emerging drug use practices and trends. Results tend to indicate greater tweeting activity about cannabis edibles in states where medical THC and/or recreational use are legal. Although the majority of tweets conveyed positive attitudes about cannabis edibles, analysis of experiences expressed in negative tweets confirms the potential adverse effects of edibles and calls for educating edibles-naïve users, g, an improving edibles labelin
Clinical and functional correlates of processing speed in pediatric Attention-Deficit/Hyperactivity Disorder: a systematic review and meta-analysis

ABSTRACT It is well established that processing speed is negatively impacted in children and adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD). Unfortunately, exactly how processing speed vulnerabilities manifest in daily functioning has not been well established. To support clinical care of youth with ADHD, it is important to better understand the functional consequences and relevant outcomes associated with processing speed deficits. This systematic review and meta-analysis sought to identify the association between processing speed and clinical or functional correlates among children or adolescents diagnosed with ADHD. A total of 409 abstracts were screened, of which, 60 full-text articles were identified as potentially relevant, and 8 of these studies met inclusion criteria. Domains evaluated across these studies included reading skills, mathematics skills, written expression, anxiety, self-appraisals of competence, and adaptive functioning. Six studies reported an association between processing speed and reading skills, allowing for meta-analysis. Processing speed difficulties among youth with ADHD appear strongly associated with several clinical and functional correlates including weaker academic skills, poorer adaptive skills, increased self-reported anxiety, and overestimates of social competence. Meta-analytic results for studies reporting the association between processing speed and reading skills indicate a medium overall weighted mean effect size (r = 0.33, 95% CI = 0.28 –0.39) with minimal heterogeneity (I2 = 0.17). Clinical implications of these findings, limitations in the current knowledge base, and suggestions for future research are discussed.
Enhanced killing of human epidermoid carcinoma (KB) cells by treatment with ricin encapsulated into sterically stabilized liposomes in combination with monensin

Ricin was encapsulated in various charged liposomes having 5mol% PEG of different chain length on the surface. The cytotoxicity of ricin entrapped in these liposomal formulations was examined in human epidermoid carcinoma (KB) cells with a view to develop an optimum delivery system for ricin in vivo. It was observed that the cytotoxicity of ricin entrapped in various charged liposomes was significantly dependent on the surface charge as well as chain length of PEG. The maximum cytotoxicity of ricin was observed when it was delivered through negatively charged liposomes having 5 mol% PEG-2000 on the surface. Monensin enhances the cytotoxicity of ricin entrapped in various charged liposomes depending on the surface charge. Maximum potentiation of cytotoxicity of ricin was observed when it was delivered through negatively charged liposomes having 5 mol% PEG-2000 on the surface. Studies on the kinetics of inhibition of protein synthesis by ricin revealed that the lag period of inhibition of protein synthesis is significantly lengthened following its delivery through various charged liposomes. Monensin significantly reduced the lag period of action of ricin. It was also observed that the efficacies of monensin on the enhancement of cytotoxicity of ricin entrapped in various charged PEG-liposomes were highly related to their amount of cell association. The current study has demonstrated that by suitable adjustment of charge, density, and chain length of PEG on the surface of liposomes it would be possible to direct liposomal ricin to human tumor cells for their selective elimination in combination with monensin.