Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of Prognostic Genes for Recurrent Risk Prediction in Triple Negative Breast Cancer Patients in Taiwan

Discrepancies in the prognosis of triple negative breast cancer exist between Caucasian and Asian populations. Yet, the gene signature of triple negative breast cancer specifically for Asians has not become available. Therefore, the purpose of this study is to construct a prediction model for recurrence of triple negative breast cancer in Taiwanese patients. Whole genome expression profiling of breast cancers from 185 patients in Taiwan from 1995 to 2008 was performed, and the results were compared to the previously published literature to detect differences between Asian and Western patients. Pathway analysis and Cox proportional hazard models were applied to construct a prediction model for the recurrence of triple negative breast cancer. Hierarchical cluster analysis showed that triple negative breast cancers from different races were in separate sub-clusters but grouped in a bigger cluster. Two pathways, cAMP-mediated signaling and ephrin receptor signaling, were significantly associated with the recurrence of triple negative breast cancer. After using stepwise model selection from the combination of the initial filtered genes, we developed a prediction model based on the genes SLC22A23, PRKAG3, DPEP3, MORC2, GRB7, and FAM43A. The model had 91.7% accuracy, 81.8% sensitivity, and 94.6% specificity under leave-one-out support vector regression. In this study, we identified pathways related to triple negative breast cancer and developed a model to predict its recurrence. These results could be used for assisting with clinical prognosis and warrant further investigation into the possibility of targeted therapy of triple negative breast cancer in Taiwanese patients.
PERSONALITY DISORDERS AND THE PERSISTENCE OF ANXIETY DISORDERS IN A NATIONALLY REPRESENTATIVE SAMPLE

Among individuals with anxiety disorders, comorbid personality disorders (PDs) increase cross‐sectional symptom severity and decrease functioning. Little is known, however, about how PDs influence the course of anxiety disorders over time. The purpose of this study was to examine the effect of PDs on the persistence of four anxiety disorders in a nationally representative sample in the United States.
Genome size variation and species diversity in salamanders

Salamanders (Urodela) have among the largest vertebrate genomes, ranging in size from 10 to 120 pg. Although changes in genome size often occur randomly and in the absence of selection pressure, non-random patterns of genome size variation are evident among specific vertebrate lineages. Several reports suggest a relationship between species richness and genome size, but the exact nature of that relationship remains unclear both within and across different taxonomic groups. Here we report i) a negative relationship between haploid genome size (C-value) and species richness at the family taxonomic level in salamander clades; ii) a correlation of C-value and species richness with clade crown-age but not with diversification rates; iii) strong associations between C-value and either geographical area or climatic niche rate. Finally, we report a relationship between C-value diversity and species diversity at both the family and genus level clades in urodeles.
D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis

AbstractNo early serum marker of disease severity contributes to the treatment decision-making process of acute superior mesenteric venous thrombosis (ASMVT). This study aims to assess the value of serum D-dimer level in the first 3 days after admission as a severity marker of ASMVT patients.From May 2010 to June 2014, 50 consecutive patients of ASMVT were enrolled in this observational study. The serum D-dimer level was measured on a daily basis during the first 3 days after admission as well as other laboratory-testing parameters, clinical score, and outcome variables recorded during the same period. The maximum and mean D-dimer values were analyzed and compared with other potential markers for prediction of multiple-organ dysfunction syndrome (MODS) and short-bowel syndrome (SBS). The correlation of D-dimer level with other potential severity markers and inflammation parameters were also studied.Both maximum and mean D-dimer level during the first 3 days of admission were significantly higher in patients with several clinical variables such as death within 30 days, bowel resection, sepsis, abdominal compartment syndrome, MODS, and SBS. In addition, serum D-dimer level showed precise prediction for MODS and SBS, greater than L-lactate and intestinal-type fatty acid-binding protein (I-FABP). The D-dimer level was correlated well with L-lactate, I-FABP, and APACHE II score on the first 3 days of admission. Poor correlation of D-dimer level and inflammation parameters, white blood cell count, and C-reactive protein level, was detected.D-dimer level could be an effective, early, and specific serum marker indicating the clinical evolution and outcome of ASMVT.
CryptoScan: A Secured Scan Chain Architecture

Scan based testing is a powerful and popular test technique. However the scan chain can be used by an attacker to decipher the cryptogram. The present paper shows such a side-channel attack on LFSR-based stream ciphers using scan chains. The paper subsequently discusses a strategy to build the scan chains in a tree based pattern with a selfchecking compactor. It has been shown that such a structure prevents such scan based attacks but does not compromise on fault coverage.
Dosage is more than just counting program hours: The importance of role-playing in treatment outcomes

ABSTRACT The risk principle directs correctional practitioners to provide greater amounts of correctional treatment to higher-risk offenders, while the responsivity principle directs practitioners to target criminogenic needs using treatment modalities that have been shown to be the most effective at reducing recidivism for offenders as a group. One such treatment modality is cognitive-behavioral treatment. Consequently, more studies are attempting to identify the most effective amounts of cognitive-behavioral treatment to provide to offenders of varying risk levels in an effort to maximize recidivism reductions. This article builds upon prior dosage research by examining whether time spent on a specific strategy commonly employed in cognitive-behavioral programs—the use of role-play—serves as a moderator of the risk–dosage relationship. It does so using a sample of 980 male offenders who received treatment in a community-based correctional program in Ohio. The results indicate that practitioners should continue to match treatment dosage to risk, strive to provide the optimal amount of dosage suggested by previous studies, and maximize use of behavioral rehearsal techniques such as role-play.
Geometric and elastostatic calibration of robotic manipulator using partial pose measurements

The paper deals with the geometric and elastostatic calibration of robotic manipulator using partial pose measurements, which do not provide the end-effector orientation. The main attention is paid to the efficiency improvement of identification procedure. In contrast to previous works, the developed calibration technique is based on the direct measurements only. To improve the identification accuracy, it is proposed to use several reference points for each manipulator configuration. This allows avoiding the problem of non-homogeneity of the least-square objective, which arises in the classical identification technique with the full pose information (position and orientation). Its efficiency is confirmed by the comparison analysis, which deals with the accuracy evaluation of different identification strategies. The obtained theoretical results have been successfully applied to the geometric and elastostatic calibration of a serial industrial robot employed in a machining work cell for aerospace industry. Graphical Abstract
Design and modeling of a micromachined high-Q tunable capacitor with large tuning range and a vertical planar spiral inductor

In wireless communication systems, passive elements including tunable capacitors and inductors often need high quality factor (Q-factor). In this paper, we present the design and modeling of a novel high Q-factor tunable capacitor with large tuning range and a high Q-factor vertical planar spiral inductor implemented in microelectromechanical system (MEMS) technology. Different from conventional two-parallel-plate tunable capacitors, the novel tunable capacitor consists of one suspended top plate and two fixed bottom plates. One of the two fixed plates and the top plate form a variable capacitor, while the other fixed plate and the top plate are used to provide electrostatic actuation for capacitance tuning. For the fabricated prototype tunable capacitors, a maximum controllable tuning range of 69.8% has been achieved, exceeding the theoretical tuning range limit (50%) of conventional two-parallel-plate tunable capacitors. This tunable capacitor also exhibits a very low return loss of less than 0.6 dB in the frequency range from 45 MHz to 10 GHz. The high Q-factor planar coil inductor is first fabricated on a silicon substrate and then assembled to the vertical position by using a novel three-dimensional microstructure assembly technique called plastic deformation magnetic assembly (PDMA). Inductors of different dimensions are fabricated and tested. The S-parameters of the inductors before and after PDMA are measured and compared, demonstrating superior performance due to reduced substrate loss and parasitics. The new vertical planar spiral inductor also has the advantage of occupying much smaller silicon areas than the conventional planar spiral inductors.
Neuroimage: Clinical Specific Brain Morphometric Changes in Spinal Cord Injury with and without Neuropathic Pain

Why only certain patients develop debilitating pain after spinal chord injury and whether structural brain changes are implicated remain unknown. The aim of this study was to determine if patients with chronic, neuropathic below-level pain have specific cerebral changes compared to those who remain pain-free. Voxel-based morphometry of high resolution, T1-weighted images was performed on three subject groups comprising patients with pain (SCI-P, n = 18), patients without pain (SCI-N, n = 12) and age-and sex-matched controls (n = 18). The SCI-P group was first compared directly with the SCI-N group and then subsequently with controls. Overall, grey and white matter changes dependent on the presence of pain were revealed. Significant changes were found within the somatosensory cortex and also in corticospinal tracts and visual-processing areas. When the SCI-P group was directly compared with the SCI-N group, reduced grey matter volume was found in the deafferented leg area of the somatosensory cortex bilaterally. This region negatively correlated with pain intensity. Relative to controls, grey matter in this paracentral primary sensory cortex was decreased in SCI-P but conversely increased in SCI-N. When compared with controls, discrepant corticospinal tract white matter reductions were found in SCI-P and in SCI-N. In the visual cortex, SCI-N showed increased grey matter, whilst the SCI-N showed reduced white matter. In conclusion, structural changes in SCI are related to the presence and degree of below-level pain and involve but are not limited to the sensorimotor cortices. Pain-related structural plasticity may hold clinical implications for the prevention and management of refractory neuropathic pain.
Modeling Buying Motives for Personalized Product Bundle Recommendation

Product bundling is a marketing strategy that offers several products/items for sale as one bundle. While the bundling strategy has been widely used, less efforts have been made to understand how items should be bundled with respect to consumers’ preferences and buying motives for product bundles. This article investigates the relationships between the items that are bought together within a product bundle. To that end, each purchased product bundle is formulated as a bundle graph with items as nodes and the associations between pairs of items in the bundle as edges. The relationships between items can be analyzed by the formation of edges in bundle graphs, which can be attributed to the associations of feature aspects. Then, a probabilistic model BPM (Bundle Purchases with Motives) is proposed to capture the composition of each bundle graph, with two latent factors node-type and edge-type introduced to describe the feature aspects and relationships respectively. Furthermore, based on the preferences inferred from the model, an approach for recommending items to form product bundles is developed by estimating the probability that a consumer would buy an associative item together with the item already bought in the shopping cart. Finally, experimental results on real-world transaction data collected from well-known shopping sites show the effectiveness advantages of the proposed approach over other baseline methods. Moreover, the experiments also show that the proposed model can explain consumers’ buying motives for product bundles in terms of different node-types and edge-types.
The Expendables: A Qualitative Study of Police Officers’ Responses to Organizational Injustice

The purpose of this study was to identify events linked to police officers’ assessments of fairness within their departments, identify how officers’ felt about events they perceived as unfair, and record officers’ responses to perceived organizational injustice. This was a qualitative study that applied a phenomenological approach and information was collected from 24 officers through the use of semistructured interviews. The predominant organizational events linked to fairness assessments among participants included disciplinary actions, citizen complaints, blocked career aspirations, and officer–supervisor conflicts. Overwhelmingly, officers reported these events made them feel angry. These events fostered feelings of increased skepticism and not being supported or feeling expendable. Analyses of data revealed two salient forms of negative work outcomes as responses to perceived organizational injustice: production deviance and self-protective behaviors. This study expands our understanding of which events foster negative perceptions of injustice while exposing how police officers react to those experiences. These findings should be of particular interest to individuals interested in policing, organizational justice, or organizational behavior.
Dentigerous Cyst associated with Horizontally Impacted Mandibular Second Premolar

ABSTRACT Dentigerous Cyst/developmental cyst of benign odontogenic origin are ones that surround the crown of impacted, embedded, unerupted or developing teeth. Dentigerous cyst is second most common cyst of the oral cavity after radicular cyst. They are usually solitary in occurrence and mostly associated with the mandibular third molars. Dentigerous cysts involving impacted second premolars are rarely reported in the literatures. We present a rare case of dentigerous cyst in a 12-year-old female patient associated with an impacted mandibular second premolar. How to cite this article: Mishra R, Tripathi AM, Rathore M. Dentigerous Cyst associated with Horizontally Impacted Mandibular Second Premolar. Int J Clin Pediatr Dent 2014;7(1): 54-57.
Associations between school climate, suicidal thoughts, and behaviors and ethnicity among middle school students

The purpose of the current study is to investigate the relationships between suicidal thoughts and behaviors (STBs), school climate, and student demographics among middle school students. The study was conducted with a sample of 152,191 middle school students across 607 schools within 182 school districts in a southeastern state. Results support prior research that positive perceptions of school climate are associated with fewer reports of STB. Participants identified family reasons, bullying, peer problems, and “other” as the most common reasons for STB. Further, older students and males were more likely to engage in STB than their counterparts. When examining cross-sectional interactions, race/ethnicity moderated the relationship between school climate and STB. Findings from the study support the role of school psychologists in advocating for prevention and intervention STB supports for middle school students with particular attention to students who may be at increased risk based on group identification. Implications for future research and practice are discussed.
Family, Identity, and the American Dream: Service Providers’ Perspectives on Families’ Experiences With Foreclosure

This article reports the findings from in-depth qualitative interviews with 18 service providers who worked with families facing foreclosure. The interviews’ purpose was to better understand a broad range of families’ experiences and inductive coding focused on quotes that reflected the meaning of those experiences. The analysis extracted three main themes related to foreclosure representing threat: (a) foreclosure threatened children’s education, (b) foreclosure threatened family memories, and (c) foreclosure threatened clients’ sense of self and attaining the American Dream. Providers reported that families fought to keep their homes and hoped to buy again after foreclosure. The findings suggest that social work services could be beneficial in helping families navigate the emotional and financial impact of the foreclosure experience.
On Nilpotency and Asymptotic Nilpotency of Cellular Automata

One of the most interesting aspects in the theory of cellular automata is the study of different typesof nilpotency, that is, different ways in which a cellular automaton can force a particular symbol (usu-ally called 0) to appear frequently in all its spacetime diagrams. The simplest such notion, called sim-ply ‘nilpotency’, is that the cellular automaton c maps every conﬁguration to a uniform conﬁguration:::000:::, on which it behaves as the identity, in a uniformly bounded number of steps, that is, c
Whole-Metagenome-Sequencing-Based Community Profiles of Vitis vinifera L. cv. Corvina Berries Withered in Two Post-harvest Conditions

Vitis vinifera L. cv. Corvina grape forms the basis for the production of unique wines, such as Amarone, whose distinctive sensory features are strongly linked to the post-harvest grape withering process. Indeed, this process increases sugar concentration and changes must characteristics. While microorganisms involved in must fermentation have been widely investigated, few data are available on the microbiota of withered grapes. Thus, in this paper, a whole metagenome sequencing (WMS) approach was used to analyse the microbial consortium associated with Corvina berries at the end of the withering process performed in two different conditions (“traditional withering,” TW or “accelerated withering,” AW), and to unveil whether changes of drying parameters could have an impact on microbial diversity. Samples of healthy undamaged berries were collected and washed, to recover microorganisms from the surface and avoid contamination with grapevine genetic material. Isolated DNA was sequenced and the data obtained were analyzed with several bioinformatics methods. The eukaryotic community was mainly composed by members of the phylum Ascomycota, including Eurotiomycetes, Sordariomycetes, and Dothideomycetes. Moreover, the distribution of the genera Aspergillus and Penicillium (class Eurotiomycetes) varied between the withered berry samples. Instead, Botryotinia, Saccharomyces, and other wine technologically useful microorganisms were relatively scarce in both samples. For prokaryotes, 25 phyla were identified, nine of which were common to both conditions. Environmental bacteria belonging to the class Gammaproteobacteria were dominant and, in particular, the TW sample was characterized by members of the family Pseudomonadaceae, while members of the family Enterobacteriaceae dominated the AW sample, in addition to Sphyngobacteria and Clostridia. Finally, the binning procedure discovered 15 putative genomes which dominated the microbial community of the two samples, and included representatives of genera Erwinia, Pantoea, Pseudomonas, Clostridium, Paenibacillus, and of orders Lactobacillales and Actinomycetales. These results provide insights into the microbial consortium of Corvina withered berries and reveal relevant variations attributable to post-harvest withering conditions, underling how WMS could open novel perspectives in the knowledge and management of the withering process of Corvina, with an impact on the winemaking of important Italian wines.
Rent-Sharing, Holdup, and Wages: Evidence from Matched Panel Data

It is widely believed that rent-sharing reduces the incentives for investment when long term contracts are infeasible because some of the returns to sunk capital are captured by workers. We propose a simple test for the degree of hold-up based on the fraction of capital costs that are deducted from the quasi-rent that determines negotiated wages. We implement the test using a data set that combines Social Security earnings records for workers in the Veneto region of Italy with detailed financial information for employers. We find strong evidence of rent-sharing, with an elasticity of wages with respect to current profitability of the firm of 3-7%, arising mainly from firms in concentrated industries. On the other hand we find little evidence that bargaining lowers the return on investment. Instead, firm-level bargaining appears to split the rents after deducting the full cost of capital.
The Erwin Schrr Odinger International Institute for Mathematical Physics the Euler-poincar E Equations and Double Bracket Dissipation the Euler-poincar E Equations and Double Bracket Dissipation

Available via anonymous ftp or gopher from FTP. Abstract This paper studies the perturbation of a Lie-Poisson (or, equivalently an Euler-Poincar e) system by a special dissipation term that has Brockett's double bracket form. We show that a formally unstable equilibrium of the un-perturbed system becomes a spectrally and hence nonlinearly unstable equilibrium after the perturbation is added. We also investigate the geometry of 1 this dissipation mechanism and its relation to Rayleigh dissipation functions. in which we studied the corresponding problem for systems with symmetry with the dissipation added to the internal variables; here it is added directly to the group or Lie algebra variables. The mechanisms discussed here include a number of interesting examples of physical interest such as the Landau-Lifschitz equations for ferromagnetism, certain models for dissipative rigid body dynamics and geophysical uids, and certain relative equilibria in plasma physics and stellar dynamics.