Miracle-dz/UniFAR-FTUs huggingface dataset:
When more is less: the paradox of choice in search engine use

In numerous everyday domains, it has been demonstrated that increasing the number of options beyond a handful can lead to paralysis and poor choice and decrease satisfaction with the choice. Were this so-called paradox of choice to hold in search engine use, it would mean that increasing recall can actually work counter to user satisfaction if it implies choice from a more extensive set of result items. The existence of this effect was demonstrated in an experiment where users (N=24) were shown a search scenario and a query and were required to choose the best result item within 30 seconds. Having to choose from six results yielded both higher subjective satisfaction with the choice and greater confidence in its correctness than when there were 24 items on the results page. We discuss this finding in the wider context of "choice architecture"--that is, how result presentation affects choice and satisfaction.
The clinical utility of aflibercept for diabetic macular edema

The treatment of center-involving diabetic macular edema (DME) has improved because of the proven efficacy of drugs that inhibit the effects of vascular endothelial growth factor (VEGF). The newest anti-VEGF drug, aflibercept, has recently been approved by the United States Food and Drug Administration for the treatment of center-involving DME and for diabetic retinopathy in eyes with DME. In the pivotal Phase III VISTA and VIVID trials, intravitreal aflibercept 2 mg injections every 4 or 8 weeks (after 5 monthly loading doses) produced superior gains in BCVA compared to laser/sham injections. In the Diabetic Retinopathy Clinical Research Network Protocol T trial, which featured monthly anti-VEGF monotherapy for 6 months, followed by monthly pro re nata anti-VEGF injections with laser rescue therapy from months 6 through 12, aflibercept 2 mg monthly was superior to bevacizumab 1.25 mg and ranibizumab 0.5 mg in eyes with BCVA of 20/50 or worse (aflibercept versus bevacizumab: P<0.001; aflibercept versus ranibizumab: P=0.003), but the three regimens were comparable for eyes with VA of 20/40 or better. Only in the 20/50 or worse subgroup did aflibercept achieve clinical superiority (>5 letter difference) to bevacizumab. Each treatment regimen led to significant macular thinning, with aflibercept being superior to bevacizumab in both visual acuity subgroups (P<0.001 for each), but it was not statistically superior to ranibizumab in either group. In diabetic patients, aflibercept has an excellent safety profile that does not appear to differ from laser/sham or other VEGF inhibitory drugs.
Hunger promotes acquisition of nonfood objects

Significance Hunger is assumed to motivate eating, which satisfies the caloric needs underlying the motivation. However, hunger’s influence extends beyond food consumption to the acquisition of nonfood items that cannot satisfy the underlying need (e.g., binder clips), suggesting that domain-specific motives can influence behavior in unrelated domains that are irrelevant to the motive. This is likely to occur when the domain-specific response includes concepts and behaviors that can also guide decisions in other domains. Hunger motivates people to consume food, for which finding and acquiring food is a prerequisite. We test whether the acquisition component spills over to nonfood objects: Are hungry people more likely to acquire objects that cannot satisfy their hunger? Five laboratory and field studies show that hunger increases the accessibility of acquisition-related concepts and the intention to acquire not only food but also nonfood objects. Moreover, people act on this intention and acquire more nonfood objects (e.g., binder clips) when they are hungry, both when these items are freely available and when they must be paid for. However, hunger does not influence how much they like nonfood objects. We conclude that a basic biologically based motivation can affect substantively unrelated behaviors that cannot satisfy the motivation. This presumably occurs because hunger renders acquisition-related concepts and behaviors more accessible, which influences decisions in situations to which they can be applied.
High Spectral and Spatial Resolution Observations of Shocked Molecular Hydrogen at the Galactic Center

The presence of OH (1720 MHz) masers and the absence of counterparts at 1665/1667 MHz has proved to be a clear diagnostic of shocked molecular gas associated with Galactic supernova remnants. This suggests that shocked molecular gas should be associated with the OH (1720 MHz) masers that have been detected in the circumnuclear disk (CND) and Sgr A East at the Galactic center. In order to test this hypothesis, we observed the H2 1-0 S(1) and Brγ lines using NICMOS on the Hubble Space Telescope (HST) and the University of New South Wales Infrared Fabry-Perot (UNSWIRF) etalon at the Anglo-Australian Telescope (AAT), near the regions where OH (1720 MHz) masers are detected in the CND and Sgr A East. We present the distribution of H2 in the north and south lobes of the CND and in Sgr A East. H2 emission accompanies almost all the maser spots detected at the Galactic center. In particular, we find a striking filamentary structure near the northwest of the CND and evidence that shocked molecular gas is associated with the 70 km s-1 molecular cloud at the Galactic center. We argue that the emission from the CND could arise in gas heated by the dissipation of the random motion of clumps by collisions or the dissipation of turbulence in a more homogeneous medium. In addition, highly redshifted gas of up to 140 km s-1 close to the eastern edge of the Sgr A East shell is detected. These observations combined with OH (1720 MHz) results suggest that the H2 gas is shocked and accelerated by the expansion of Sgr A East into the 50 and the 70 km s-1 clouds and into the lobes of the CND.
Elliptical and Archimedean copulas in Estimation of Distribution Algorithm with model migration

Estimation of distribution algorithms (EDAs) are stochastic optimization techniques that are based on building and sampling a probability model. Copula theory provides methods that simplify the estimation of a probability model. An island-based version of copula-based EDA with probabilistic model migration (mCEDA) was tested on a set of well-known standard optimization benchmarks in the continuous domain. We investigated two families of copulas - Archimedean and elliptical. Experimental results confirm that this concept of model migration (mCEDA) yields better convergence as compared with the sequential version (sCEDA) and other recently published copula-based EDAs.
A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus

Although central to pathogenesis, the molecular mechanisms used by microbes to regulate virulence factor production in specific environments during host–pathogen interaction are poorly defined. Several recent ex vivo and in vivo studies have found that the level of group A Streptococcus (GAS) virulence factor gene transcripts is temporally related to altered expression of genes encoding carbohydrate utilization proteins. These findings stimulated us to analyze the role in pathogenesis of catabolite control protein A (CcpA), a GAS ortholog of a key global regulator of carbohydrate metabolism in Bacillus subtilis. Inasmuch as the genomewide effects of CcpA in a human pathogen are unknown, we analyzed the transcriptome of a ΔccpA isogenic mutant strain grown in nutrient-rich medium. CcpA influences the transcript levels of many carbohydrate utilization genes and several well characterized GAS virulence factors, including the potent cytolysin streptolysin S. Compared with the wild-type parental strain, the ΔccpA isogenic mutant strain was significantly less virulent in a mouse model of invasive infection. Moreover, the isogenic mutant strain was significantly impaired in ability to colonize the mouse oropharynx. When grown in human saliva, a nutrient-limited environment, CcpA influenced production of several key virulence factors not influenced during growth in nutrient-rich medium. Purified recombinant CcpA bound to the promoter region of the gene encoding streptolysin S. Our discovery that GAS virulence and complex carbohydrate utilization are directly linked through CcpA provides enhanced understanding of a mechanism used by a Gram-positive pathogen to modulate virulence factor production in specific environments.
Agreement between a brief food frequency questionnaire and diet records using two statistical methods

Abstract Objective To compare intra- and inter-method reliability of a semi-quantitative food frequency questionnaire (FFQ) designed specifically to measure beta carotene (BC) and retinol intake, using two methods – the limits of agreement (LOA) and the correlation coefficient. Design A cross-sectional study of dietary intake. Setting A randomized trial of vitamin A supplements in 2769 subjects with past asbestos exposure. Subjects Data from 57 men and 26 women, aged 28–72 years, living in Western Australia. Methods The FFQ was administered at baseline (FFQ1) and repeated 1 year later (FFQ2). Four 1-week diet records (DRs) were completed during the year. Results Mean agreement between FFQ2 and FFQ1 was 120% for BC and 98% for retinol. LOA were 47–306% and 21–459%, respectively. Mean agreement between FFQ2 and the DR was 149% for BC and 63% for retinol; LOA were 50–447% and 11–349%, respectively. Mean agreement and LOA varied across energy intakes. Between the DR and FFQ2, correlation coefficients were 0.36 for BC and 0.51 for retinol. These varied considerably across age, gender and energy intakes and were not in accordance with limits of agreement findings. Conclusion Although correlation coefficients were positive and significant, there was less than ideal intra-method and inter-method reliability shown by the limits of agreement method. Bias was uneven across the range of intakes, the LOA were wide and, compared with the DR, the FFQ significantly over-estimated BC and under-estimated retinol. This shows the limitations of calculating correlation coefficients alone, for assessing reliability and validity.
Discovering multirelational structure in social media streams

In this article, we present a novel algorithm to discover multirelational structures from social media streams. A media item such as a photograph exists as part of a meaningful interrelationship among several attributes, including time, visual content, users, and actions. Discovery of such relational structures enables us to understand the semantics of human activity and has applications in content organization, recommendation algorithms, and exploratory social network analysis. We are proposing a novel nonnegative matrix factorization framework to characterize relational structures of group photo streams. The factorization incorporates image content features and contextual information. The idea is to consider a cluster as having similar relational patterns; each cluster consists of photos relating to similar content or context. Relations represent different aspects of the photo stream data, including visual content, associated tags, photo owners, and post times. The extracted structures minimize the mutual information of the predicted joint distribution. We also introduce a relational modularity function to determine the structure cost penalty, and hence determine the number of clusters. Extensive experiments on a large Flickr dataset suggest that our approach is able to extract meaningful relational patterns from group photo streams. We evaluate the utility of the discovered structures through a tag prediction task and through a user study. Our results show that our method based on relational structures, outperforms baseline methods, including feature and tag frequency based techniques, by 35%--420%. We have conducted a qualitative user study to evaluate the benefits of our framework in exploring group photo streams. The study indicates that users found the extracted clustering results clearly represent major themes in a group; the clustering results not only reflect how users describe the group data but often lead the users to discover the evolution of the group activity.
Utility of diffusion‐weighted MRI in distinguishing benign and malignant hepatic lesions

To evaluate apparent diffusion coefficient (ADC) values for characterization of a variety of focal liver lesions and specifically for differentiation of solid benign lesions (focal nodular hyperplasia [FNH] and adenomas) from solid malignant neoplasms (metastases and hepatocellular carcinoma [HCC]) in a large case series.
Is there an association between ossification of the cartilages of the foot and collateral desmopathy of the distal interphalangeal joint or distal phalanx injury?

REASONS FOR PERFORMING STUDY Associations between degree of ossification of the cartilages of the foot and injuries to other structures of the foot have been suggested, but have not been investigated by large scale studies. OBJECTIVES To describe the frequency of grade >3 ossification of the cartilages of the foot (possibly significant ossification, PSO), mediolateral symmetry of ossification and left-right symmetry between feet; and to investigate associations between PSO and injury of either the collateral ligaments (CLs) of the distal interphalangeal (DIP) joint or the distal phalanx. HYPOTHESES Possibly significant ossification of the cartilages of the foot is associated with CL and distal phalanx injury. Distal phalanx injury is associated with a mediolateral difference in ossification grade of > or =2. METHODS Horses were examined for lameness localised to the foot by perineural analgesia, and underwent radiographic and magnetic resonance imaging examinations. Age, breed, occupation, duration of lameness, lame(st) limb, primary cause of lameness, and presence or absence of CL injury were recorded. Dorsopalmar (dorsoplantar) radiographs were examined and ossification of the cartilages of the foot graded using a modification of a previously published scale. RESULTS One foot from each of 462 horses was included for analysis. There was left-right symmetry of ossification between feet, and significant association between grades of each foot, with lateral > or =medial cartilages. Possibly significant ossification occurred in the maximally ossified cartilage in 59 (12.8%) feet. There were significant associations between PSO of the maximally ossified cartilage of the foot and injuries of both the CLs of the DIP joint and the distal phalanx. There was no association between distal phalanx injury and marked asymmetry of the ossified cartilages of the foot. CONCLUSIONS AND CLINICAL RELEVANCE Extensively ossified cartilages of the foot are significantly associated with CL or distal phalanx injury. Markedly asymmetric ossification did not increase the likelihood of distal phalanx injury and should be considered at a prepurchase examination.
Breaking All the Rules: The Compact Symmetric Object 0402+379

We present results of multifrequency Very Long Baseline Array (VLBA) observations of the compact symmetric object (CSO) 0402+379. The parsec-scale morphology of 0402+379 allows us to confirm it as a CSO, while VLA data clearly show the presence of kiloparsec-scale structure. Thus, 0402+379 is only the second known CSO to possess large-scale structure. Another puzzling morphological characteristic found from our observations is the presence of two central, compact, flat-spectrum components, which we identify as possible active nuclei. We also present the discovery of neutral hydrogen absorption along the southern hot spot of 0402+379 with a central velocity ~1000 km s-1 greater than the systemic velocity. Multiepoch observations from the VLA archive, the Caltech-Jodrell Bank Survey, and the VLBA Calibrator Survey allow us to further analyze these anomalous features. Results of this analysis reveal significant motion in the northern hot spot, as well as appreciable variability in both of the core candidates. We consider the possibility that 0402+379 was formed during a recent merger. In this case, the two candidate cores could be interpreted as binary supermassive black holes that have not yet coalesced, whereas the large-scale radio emission could be attributed to interactions directly linked to the merger or to previous activity associated with one of the cores.
The Response of Carbon Metabolism and Antioxidant Defenses of Alfalfa Nodules to Drought Stress and to the Subsequent Recovery of Plants12[W][OA]

Alfalfa (Medicago sativa) plants were exposed to drought to examine the involvement of carbon metabolism and oxidative stress in the decline of nitrogenase (N2ase) activity. Exposure of plants to a moderate drought (leaf water potential of −1.3 MPa) had no effect on sucrose (Suc) synthase (SS) activity, but caused inhibition of N2ase activity (−43%), accumulation of succinate (+36%) and Suc (+58%), and up-regulation of genes encoding cytosolic CuZn-superoxide dismutase (SOD), plastid FeSOD, cytosolic glutathione reductase, and bacterial MnSOD and catalases B and C. Intensification of stress (−2.1 MPa) decreased N2ase (−82%) and SS (−30%) activities and increased malate (+40%), succinate (+68%), and Suc (+435%). There was also up-regulation (mRNA) of cytosolic ascorbate peroxidase and down-regulation (mRNA) of SS, homoglutathione synthetase, and bacterial catalase A. Drought stress did not affect nifH mRNA level or leghemoglobin expression, but decreased MoFe- and Fe-proteins. Rewatering of plants led to a partial recovery of the activity (75%) and proteins (>64%) of N2ase, a complete recovery of Suc, and a decrease of malate (−48%) relative to control. The increase in O2 diffusion resistance, the decrease in N2ase-linked respiration and N2ase proteins, the accumulation of respiratory substrates and oxidized lipids and proteins, and the up-regulation of antioxidant genes reveal that bacteroids have their respiratory activity impaired and that oxidative stress occurs in nodules under drought conditions prior to any detectable effect on SS or leghemoglobin. We conclude that a limitation in metabolic capacity of bacteroids and oxidative damage of cellular components are contributing factors to the inhibition of N2ase activity in alfalfa nodules.
Premature Atrial Contractions in the General Population: Frequency and Risk Factors

Background— Premature atrial contractions (PACs) are independent predictors of atrial fibrillation, stroke, and death. However, little is known about PAC frequency in the general population and its association with other cardiovascular risk factors. Methods and Results— We performed a cross-sectional analysis among participants of the population-based Swiss cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA). 24-hour Holter electrocardiograms to assess PAC prevalence and frequency were performed in a random sample of 1742 participants aged ≥50 years. The median (interquartile range) number of PACs per hour was 0.8 (0.4–1.8), 1.1 (0.5–2.4), 1.4 (0.7–4.6), 2.3 (0.8–6.9), and 2.6 (1.2–6.5) among participants aged 50 to 55, 55 to 60, 60 to 65, 65 to 70, and ≥70 years, respectively (P<0.0001). Only 18 (1.0%) participants did not have at least 1 PAC during Holter monitoring. In multivariable negative binomial regression models, PAC frequency was significantly associated with age (risk ratio [RR] per SD 1.80; P<0.0001), height (RR per SD 1.52; P<0.0001), prevalent cardiovascular disease (RR 2.40; P<0.0001), log-transformed N-terminal pro B-type natriuretic peptides (RR per SD 1.27; P<0.0001), physical activity ≥2 hours per day (RR 0.69; P=0.002), and high-density lipoprotein cholesterol (RR per SD 0.80; P=0.0002). Hypertension and body mass index were not significantly related to PAC frequency. Conclusions— To our knowledge, this is the first study to assess risk factors for PAC frequency in the general population aged ≥50 years. PACs are common, and their frequency is independently associated with age, height, history of cardiovascular disease, natriuretic peptide levels, physical activity, and high-density lipoprotein cholesterol. The underlying mechanisms of these relationships need to be addressed in future studies.
An analysis of technology usage for streaming digital video in support of a preclinical curriculum

Usage of streaming digital video of lectures in preclinical courses was measured by analysis of the data in the log file maintained on the web server. We observed that students use the video when it is available. They do not use it to replace classroom attendance but rather for review before examinations or when a class has been missed. Usage of video has not increased significantly for any course within the 18 month duration of this project.
A Comparative Study of the Effects of the Intravenous Self-Administration or Subcutaneous Minipump Infusion of Nicotine on the Expression of Brain Neuronal Nicotinic Receptor Subtypes

Long-term nicotine exposure changes neuronal acetylcholine nicotinic receptor (nAChR) subtype expression in the brains of smokers and experimental animals. The aim of this study was to investigate nicotine-induced changes in nAChR expression in two models commonly used to describe the effects of nicotine in animals: operant (two-lever presses) intravenous self-administration (SA) and passive subcutaneous nicotine administration via an osmotic minipump (MP). In the MP group, α4β2 nAChRs were up-regulated in all brain regions, α6β2* nAChRs were down-regulated in the nucleus accumbens (NAc) and caudate-putamen, and α7 nAChRs were up-regulated in the caudal cerebral cortex (CCx); the up-regulation of α4β2α5 nAChRs in the CCx was also suggested. In the SA group, α4β2 up-regulation was lower and limited to the CCx and NAc; there were no detectable changes in α6β2* or α7 nACRs. In the CCx of the MP rats, there was a close correlation between the increase in α4β2 binding and α4 and β2 subunit levels measured by means of Western blotting, demonstrating that the up-regulation was due to an increase in α4β2 proteins. Western blotting also showed that the increase in the β2 subunit exceeded that of the α4 subunit, suggesting that a change in α4β2 stoichiometry may occur in vivo as has been shown in vitro. These results show that nicotine has an area-specific effect on receptor subtypes, regardless of its administration route, but the effect is quantitatively greater in the case of MP administration.
Optimal mechanisms for selling information

The buying and selling of information is taking place at a scale unprecedented in the history of commerce, thanks to the formation of online marketplaces for user data. Data providing agencies sell user information to advertisers to allow them to match ads to viewers more effectively. In this paper we study the design of optimal mechanisms for a monopolistic data provider to sell information to a buyer, in a model where both parties have (possibly correlated) private signals about a state of the world, and the buyer uses information learned from the seller, along with his own signal, to choose an action (e.g., displaying an ad) whose payoff depends on the state of the world. We provide sufficient conditions under which there is a simple one-round protocol (i.e. a protocol where the buyer and seller each sends a single message, and there is a single money transfer) achieving optimal revenue. In these cases we present a polynomial-time algorithm that computes the optimal mechanism. Intriguingly, we show that multiple rounds of partial information disclosure (interleaved by payment to the seller) are sometimes necessary to achieve optimal revenue if the buyer is allowed to abort his interaction with the seller prematurely. We also prove some negative results about the inability of simple mechanisms for selling information to approximate more complicated ones in the worst case.