Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment persistence and cost-effectiveness of latanoprost/latanoprost–timolol, bimatoprost/bimatoprost–timolol, and travoprost/travoprost–timolol in glaucoma: an analysis based on the United Kingdom general practitioner research database

Objective: To compare treatment persistence and costs with 3 glaucoma treatment sequences (first-line/second-line): latanoprost/latanoprost–timolol (LLT), bimatoprost/bimatoprost–timolol (BBT), and travoprost/travoprost–timolol (TTT), derived from the UK General Practitioner Research Database (UK-GPRD). Methods: Patient records referring to ocular hypertension, topical glaucoma treatment, surgery, or laser therapy were extracted. Patients prescribed LLT, BBT, or TTT sequences were selected. Treatment failure was inferred from glaucoma prescription change (adding or removing a topical treatment, surgery, or laser therapy). Treatment durations preceding failure were compared by applying Wilcoxon’s test to survival curves. Adjustment on confounding variables was performed with a Cox model and a propensity score method. Unit costs were estimated from a UK National Health Service perspective. Results: A total of 1592 patients received LLT, 110 BBT, and 114 TTT. Their mean age was 68 years and the sex ratio almost 1 male:1 female. No significant demographic or comorbidity differences were observed between treatment sequences. Treatment persistence at 36 months was achieved in 60.0% of LLT, 55.5% of BBT, and 70.3% of TTT patients (P = 0.005). Resources consumed and associated monthly costs were significantly less for the TTT group (£17.74) compared with BBT (£21.30) and LLT (£22.37) groups. Conclusion: Analysis of data obtained from the UK-GPRD suggests that the TTT treatment sequence achieved longer treatment persistence at lower cost than LLT and BBT.
The Effects Of User Participation On System Success: Toward A Contingency Theory Of User Satisfaction

User participation is an important construct in IS research. It is also a frequently employed practical implementation strategy. However, research findings concerning the effects of user participation on system success are mixed and inconclusive. This study reviews a contingency theory of attitude change, proposes competing models and empirically tests the models in end-user computing involving multiple end-user user groups. Results lend support to the Cognition Fit Model. This suggests that managing the fit of user's desired participation and the actual amount of participation contributed more consistently toward user satisfaction than simply controlling the actual amount of participation. Other models receive only partial support.
Effect of various levels of date palm kernel on growth performance of broilers

Aim: The aim of this study was the assessment of various levels of date palm kernel (DPK) on the growth performance of broilers. Materials and Methods: A 250-day-old broiler chicks were randomly selected and categorized into five groups (50 chicks/group) contained A (control), B, C, D and E fed with 0%, 1%, 2%, 3% and 4% levels of DPK in balanced ration, respectively, for 6 weeks. Feed and water intake were recorded daily in the morning and evening. The data for feed intake, water intake, live body weight, and feed conversion ratio (FCR) were recorded from all birds regularly. The carcass weight and percentage obtained via six slaughtered birds were randomly selected from each group. Finally, economic aspects of the rations evaluated. Results: The most feed intakes of broilers were recorded in Group A (3915.1 g) that was significantly higher than Groups D and E. The highest water intake was in Group E (9067.78 ml) that was significantly higher than Group A and control group. Live body weight was highest in Group E (979.85 g) than Groups B, C, and control group. The best growth weights were determined significantly in Groups D (1921.96 g) and E (1935.95 g). The lowest FCRs were indicated significantly in Groups D (1.97 g/g) and E (1.92 g/g) than Groups B and A. The highest carcass weights were recorded in Groups D (1214.01 g) and E (1230.88 g) that were significantly more than other groups. Dressing percentages in Groups D (61.76%) and E (62.17%) were higher than other groups (p<0.05). The net profits (Rs.) in Groups A, B, C, D and E were indicated 27.01, 32.77, 36.78, 43.47 and 44.51 per broiler, respectively. Conclusion: It was concluded that the high levels of DPK (3-4%) significantly decreased broiler feed intake and increased water intake, live body weight, growth weight, carcass weight, dressing percentage, net profit per bird and also had positive effects on growth of broilers.
Antibacterial and Antioxidant Activities of Derriobtusone A Isolated from Lonchocarpus obtusus

This study evaluated the effect of derriobtusone A, a flavonoid isolated from Lonchocarpus obtusus, on two important pathogenic bacteria, Staphylococcus aureus and Escherichia coli, as well as its antioxidant activity and toxicity. Planktonic growth assays were performed, and the inhibition of biofilm formation was evaluated. In addition, antioxidant activity was assessed by DPPH radical scavenging assay, ferrous ion chelating assay, ferric-reducing antioxidant power assay, and β-carotene bleaching assay. Toxicity was evaluated by the brine shrimp lethality test. Results showed that derriobtusone A completely inhibited the planktonic growth of S. aureus at 250 and 500 μg/mL; however, it did not have the same activity on E. coli. Derriobtusone A reduced the biomass and colony-forming unit (cfu) of S. aureus biofilm at concentrations of 250 and 500 μg/mL. In various concentrations, it reduced the biofilm biomass of E. coli, and, in all concentrations, it weakly reduced the cfu. Derriobtusone A showed highly efficient antioxidant ability in scavenging DPPH radical and inhibiting β-carotene oxidation. The compound showed no lethality to Artemia sp. nauplii. In conclusion, derriobtusone A may be an effective molecule against S. aureus and its biofilm, as well as a potential antioxidant compound with no toxicity.
The Effects of Vocational Rehabilitation for People with Cognitive Impairments

This article utilizes administrative data to examine both short‐ and long‐term employment impacts for people with cognitive impairments who applied for vocational rehabilitation services in Virginia in 2000. These data provide long‐term quarterly information on services and employment outcomes. We model behavior, allow for multiple service choices, use long‐run labor market data, and use valid instruments. Results imply that services generally have positive long‐run labor market outcome effects that appear to substantially exceed the cost of providing services.
Is the crisis problem growing more severe

Financial crises Lessons from the last 120 years The crisis problem is one of the dominant macroeconomic features of our age. Its prominence suggests questions like the following: Are crises growing more frequent? Are they becoming more disruptive? Are economies taking longer to recover? These are fundamentally historical questions, which can be answered only by comparing the present with the past. To this end, this paper develops and analyses a data base spanning 120 years of financial history. We find that crisis frequency since 1973 has been double that of the Bretton Woods and classical gold standard periods and is rivalled only by the crisis‐ridden 1920s and 1930s. History thus confirms that there is something different and disturbing about our age. However, there is little evidence that crises have grown longer or output losses have become larger. Crises may have grown more frequent, in other words, but they have not obviously grown more severe. Our explanation for the growing frequency and chronic costs of crises focuses on the combination of capital mobility and the financial safety net, including the implicit insurance against exchange risk provided by an ex ante credible policy of pegging the exchange rate, which encourages banks and corporations to accumulate excessive foreign currency exposures. We also provide policy recommendations for restoring stability and growth. — Michael Bordo, Barry Eichengreen, Daniela Klingebiel and Maria Soledad Martinez‐Peria
Simulating mobile and distributed systems with DEUS and ns-3

Mobile and distributed systems are characterized by decentralized goals and control, with high levels of concurrency and asynchronous interaction. Their qualitative and quantitative analysis is usually based on discrete event modeling and simulation. As most simulation tools target a specific class of problems, only a few of them may be considered truly general-purpose, yet they can hardly support the analysis of distributed systems with thousands of nodes, characterized by a high level of churn (node joins and departures) and reconfiguration of connections among nodes. To fill this gap, a few years ago we started developing an open-source, general-purpose and discrete event simulation tool, called DEUS, which is application-level oriented, Java-based, and characterized by ease of use and flexibility. However, it does not provide any package for simulating networking layers and their implementation is not foreseen, since a number of specialized tools are already available. In this paper, we present a general methodology for achieving a more realistic DEUS-based simulation of mobile and distributed systems, by leveraging on ns-3, which is generally known as a highly reliable and complete open-source tool for the discrete event simulation of Internet systems. In particular, we describe our positive experience in using ns-3's LTE-EPC package to support the simulation of a peer-to-peer overlay scheme called Distributed Geographic Table (DGT), which allows mobile nodes to efficiently share information without centralized control.
Approximating optimal spare capacity allocation by successive survivable routing

Spare capacity allocation (SCA) is an important part of a fault tolerant network design. In the spare capacity allocation problem one seeks to determine where to place spare capacity in the network and how much spare capacity must be allocated to guarantee seamless communications services survivable to a set of failure scenarios (e.g., any single link failure). Formulated as a multi-commodity flow integer programming problem, SCA is known to be NP-hard. We provide a two-pronged attack to approximate the optimal SCA solution: unravel the SCA structure and find an effective algorithm. First, a literature review on the SCA problem and its algorithms is provided. Second, a integer programming model for SCA is provided. Third, a simulated annealing algorithm using the above INP model is introduced. Next, the structure of SCA is modeled by a matrix method. The per-flow based backup path information are aggregated into a square matrix, called the spare provision matrix (SPM). The size of the SPM is the number of links. Using the SPM as the state information, a new adaptive algorithm is then developed to approximate the optimal SCA solution termed successive survivable routing (SSR). SSR routes link-disjoint backup paths for each traffic flow one at a time. Each flow keeps updating its backup path according to the current network state as long as the backup path is not carrying any traffic. In this way, SSR can be implemented by shortest path algorithms using advertised state information with complexity of O( Link/sup 2/). The analysis also shows that SSR is using a necessary condition of the optimal solution. The numerical results show that SSR has near optimal spare capacity allocation with substantial advantages in computation speed.
Plant Mediated Green Synthesis of CuO Nanoparticles: Comparison of Toxicity of Engineered and Plant Mediated CuO Nanoparticles towards Daphnia magna

Research on green production methods for metal oxide nanoparticles (NPs) is growing, with the objective to overcome the potential hazards of these chemicals for a safer environment. In this study, facile, ecofriendly synthesis of copper oxide (CuO) nanoparticles was successfully achieved using aqueous extract of Pterospermum acerifolium leaves. P. acerifolium-fabricated CuO nanoparticles were further characterized by UV-Visible spectroscopy, field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and dynamic light scattering (DLS). Plant-mediated CuO nanoparticles were found to be oval shaped and well dispersed in suspension. XPS confirmed the elemental composition of P. acerifolium-mediated copper nanoparticles as comprised purely of copper and oxygen. DLS measurements and ion release profile showed that P. acerifolium-mediated copper nanoparticles were more stable than the engineered CuO NPs. Copper oxide nanoparticles are used in many applications; therefore, their potential toxicity cannot be ignored. A comparative study was performed to investigate the bio-toxic impacts of plant-synthesized and engineered CuO nanoparticles on water flea Daphnia. Experiments were conducted to investigate the 48-h acute toxicity of engineered CuO NPs and plant-synthesized nanoparticles. Lower EC50 value 0.102 ± 0.019 mg/L was observed for engineered CuO NPs, while 0.69 ± 0.226 mg/L was observed for plant-synthesized CuO NPs. Additionally, ion release from CuO nanoparticles and 48-h accumulation of these nano CuOs in daphnids were also calculated. Our findings thus suggest that the contribution of released ions from nanoparticles and particles/ions accumulation in Daphnia needs to be interpreted with care.
Remote Ischemic Limb Preconditioning After Subarachnoid Hemorrhage: A Phase Ib Study of Safety and Feasibility

Background and Purpose— Making a limb transiently ischemic has been shown to induce ischemic tolerance in a distant organ. This phenomenon is known as remote ischemic limb preconditioning. We conducted a Phase IB study of remote ischemic limb preconditioning to determine the safety and feasibility of increasing durations of limb ischemia in patients with subarachnoid hemorrhage. Methods— Patients with aneurysmal subarachnoid hemorrhage underwent limb preconditioning every 24 to 48 hours for 14 days. Limb preconditioning consisted of 3 5-minute inflations of a blood pressure cuff to 200 mm Hg around a limb followed by 5 minutes of reperfusion. In the lead-in phase, we preconditioned the upper extremities, but this proved impractical and we began preconditioning the leg in a similar manner. Ischemia times were then escalated to 7.5 and 10 minutes. After each session, a visual analog scale was obtained and the extremity examined for neurovascular complications. Results— A total of 33 patients completed the study. Mean age was 53±12 years and mean Hunt Hess score was 2.4±0.9. In the lead-in phase, an average of 7.7±2.4 preconditioning sessions was completed with mean visual analog scale 3.6±3.4. In the dose escalation phase, an average of 8.6±2.1 preconditioning sessions was done with mean visual analog scale 1.8±2.2 and 2.5±2.9 for the 7.5- and 10-minute cohorts, respectively. No session was prematurely terminated due to subject discomfort. No objective signs of neurovascular injury were observed. Conclusions— We found limb preconditioning to be safe and well tolerated, even at ischemia times of 10 minutes, in critically ill patients with subarachnoid hemorrhage.
Reliability of Prehospital Real-Time Cellular Video Phone in Assessing the Simplified National Institutes of Health Stroke Scale in Patients With Acute Stroke: A Novel Telemedicine Technology

Background and Purpose— The National Institutes of Health Stroke Scale (NIHSS) is the gold standard to assess patients with acute stroke. We aimed to examine the feasibility and reliability of prehospital real-time cellular video phone (VP) in performing the NIHSS. Methods— Forty physicians prospectively performed a simplified NIHSS (sNIHSS) on a standardized patient remotely using VP with the assistance of a bedside emergency medical technician and later performed a bedside examination. We tested the hypothesis that there is high reliability between these 2 methods. Physicians were timed and sNIHSS scores were recorded. Finally, physicians were asked to rate the VP technology. Results— A total of 480 pair comparisons of the sNIHSS scores between the VP and bedside examination were generated. After adjusting for the physician's specialty, level of training, and certification status, there was a strong positive linear correlation (r=0.97, P<0.01) between the 2 methods with high average physician reliability (0.99; 95% CI, 0.992 to 0.995). The mean sNIHSS scores using VP and bedside examination were not different (6.82±1.06 versus 6.63±0.98; P=0.08). The mean time to perform the sNIHSS using VP was approximately 38 seconds longer than the bedside examination (3.38±0.77 versus 2.93±0.83 minutes; P=0.006). Conclusions— The VP is a feasible, reliable, and timely tool with the potential for remotely assessing the sNIHSS for patients presenting with acute stroke and may expedite the initial evaluation and treatment strategies.
Hierarchical Multiscale Recurrent Neural Networks

Learning both hierarchical and temporal representation has been among the long-standing challenges of recurrent neural networks. Multiscale recurrent neural networks have been considered as a promising approach to resolve this issue, yet there has been a lack of empirical evidence showing that this type of models can actually capture the temporal dependencies by discovering the latent hierarchical structure of the sequence. In this paper, we propose a novel multiscale approach, called the hierarchical multiscale recurrent neural networks, which can capture the latent hierarchical structure in the sequence by encoding the temporal dependencies with different timescales using a novel update mechanism. We show some evidence that our proposed multiscale architecture can discover underlying hierarchical structure in the sequences without using explicit boundary information. We evaluate our proposed model on character-level language modelling and handwriting sequence modelling.
Spontaneous Decay in the Presence of Absorbing Media

After giving a summary of the basic-theoretical concept of quantization of the electromagnetic field in the presence of dispersing and absorbing (macroscopic) bodies, their effect on spontaneous decay of an excited atom is studied. Various configurations such as bulk material, planar half space media, spherical cavities, and microspheres are considered. In particular, the influence of material absorption on the local-field correction, the decay rate, the line shift, and the emission pattern are examined. Further, the interplay between radiative losses and losses due to material absorption is analyzed. Finally, the possibility of generating entangled states of two atoms coupled by a microsphere-assisted field is discussed.
Myosin V

Calcium activates the ATPase activity of tissue-purified myosin V, but not that of shorter expressed constructs. Here, we resolve this discrepancy by comparing an expressed full-length myosin V (dFull) to three shorter constructs. Only dFull has low ATPase activity in EGTA, and significantly higher activity in calcium. Based on hydrodynamic data and electron microscopic images, the inhibited state is due to a compact conformation that is possible only with the whole molecule. The paradoxical finding that dFull moved actin in EGTA suggests that binding of the molecule to the substratum turns it on, perhaps mimicking cargo activation. Calcium slows, but does not stop the rate of actin movement if excess calmodulin (CaM) is present. Without excess CaM, calcium binding to the high affinity sites dissociates CaM and stops motility. We propose that a folded-to-extended conformational change that is controlled by calcium and CaM, and probably by cargo binding itself, regulates myosin V's ability to transport cargo in the cell.
Role of long non‐coding RNA MIAT in proliferation, apoptosis and migration of lens epithelial cells: a clinical and in vitro study

Age‐related cataract is among the most common chronic disorders of ageing and is the world's leading blinding disorder. Long non‐coding RNAs play important roles in several biological processes and complicated diseases. However, the role of lncRNAs in the setting of cataract is still unknown. Here, we extracted total RNAs from the transparent and age‐matched cataractous human lenses, and determined lncRNA expression profiles using microarray analysis. We found that 38 lncRNAs were differentially expressed between transparent and cataractous lenses. 17 of 20 differentially expressed lncRNAs were further verified by quantitative RT‐PCRs. One top abundant lncRNA, MIAT, was specifically up‐regulated both in the plasma fraction of whole blood and aqueous humor of cataract patients. MIAT knockdown could affect the proliferation, apoptosis and migration of Human lens epithelial cells (HLECs) upon oxidative stress. Posterior capsule opacification (PCO) is a common complication of cataract surgery, which is associated with abnormal production of inflammatory factors. MIAT knockdown could repress tumour necrosis factor‐α‐induced abnormal proliferation and migration of HLECs, suggesting a potential role of MIAT in PCO‐related pathological process. Moreover, we found that MIAT acted as a ceRNA, and formed a feedback loop with Akt and miR‐150‐5p to regulate HLEC function. Collectively, this study provides a novel insight into the pathogenesis of age‐related cataract.
92 kDa type IV collagenase (MMP‐9) is expressed in neutrophils and macrophages but not in malignant epithelial cells in human colon cancer

Degradation of the extracellular matrix during cancer invasion is accomplished by the concerted action of several proteolytic enzymes, including matrix metalloproteinases (MMPs). We have studied the immunohistochemical localization of one of these enzymes, 92‐kDa type IV collagenase (MMP‐9), in short‐term fixed specimens of 19 colon adenocarcinomas and 2 biopsies of adjacent normal colon. Staining was confined to neutrophils and macrophages, as identified by double staining. All neutrophils were positive in all cases. Some positively stained tumor‐infiltrating macrophages were seen in 6 (32%) of the tumors, located adjacent to invasive tumor glands. No cancer cells were stained in any of the cases. In normal colon tissue, staining was only seen of scattered neutrophils in vessels and of macrophages in Peyer's patches. Routinely processed specimens from 7 of the 19 carcinomas were analyzed by in situ hybridization. In agreement with previous results, a MMP‐9 mRNA signal was in all cases seen in a subpopulation of tissue macrophages surrounding invasive tumor glands, while no MMP‐9 mRNA was detected in any other cell types, including neutrophils and cancer cells. Our results indicate that in this type of cancer all neutrophils contain MMP‐9, which has been produced before they infiltrate the tumors; that a subpopulation of the tumor‐infiltrating macrophages most likely in all cases produces MMP‐9 but that the content of this protein is low due to a rapid turnover and that malignant epithelial cells do not produce or contain detectable amounts of MMP‐9. These findings extend previous results indicating that stromal cells are actively involved in the generation and regulation of extracellular proteolysis during cancer invasion. © 1996 Wiley‐Liss, Inc.