Miracle-dz/UniFAR-FTUs huggingface dataset:
Idiosyncratic Shocks, Geographic Spillover, and Asset Prices∗

This paper shows that idiosyncratic shocks to the top 100 U.S. companies (as identified in Gabaix (2011)) contain systematic information. Specifically, productivity shocks to the top 100 firms predict future shocks to geographically close companies. State income tax payments and implicit vertical connections are the dominant channels through which the shocks propagate. This geographic spillover is not restricted to firms’ explicit interactions, such as intra-sector, intraproduct market, or direct customer-supplier links. Market participants, including equity analysts, do not fully incorporate the geographic information contained in shocks to top 100 firms. Consequently, a trading strategy that exploits the slow diffusion of information generates an annual risk-adjusted performance of 7.3%.
The Tap42-Protein Phosphatase Type 2A Catalytic Subunit Complex Is Required for Cell Cycle-Dependent Distribution of Actin in Yeast

ABSTRACT In Saccharomyces cerevisiae, the Tor proteins mediate a wide spectrum of growth-related cellular processes in response to nutrients. The pleiotropic role of the Tor proteins is mediated, at least in part, by type 2A protein phosphatases (PP2A) and 2A-like protein phosphatases. Tor-mediated signaling activity promotes the interaction of phosphatase-interacting protein Tap42 with PP2A and 2A-like protein phosphatases. The distinct complexes formed between Tap42 and different phosphatases mediate various cellular events and modulate phosphorylation levels of many downstream factors in the Tor pathway in a Tor-dependent and rapamycin-sensitive manner. In this study, we demonstrate that the interaction between Tap42 and the catalytic subunits of PP2A (PP2Ac) is required for cell cycle-dependent distribution of actin. We show that mutations in PP2Ac and Tap42 that perturb the interaction cause random distribution of actin during the cell cycle and that overexpression of the Rho2 GTPase suppresses the actin defects associated with the mutants. Our findings suggest that the Tap42-PP2Ac complex regulates the actin cytoskeleton via a Rho GTPase-dependent mechanism. In addition, we provide evidence that PP2A activity plays a negative role in controlling the actin cytoskeleton and, possibly, in regulation of the G2/M transition of the cell cycle.
Improving the implementation of nutrition guidelines in childcare centres improves child dietary intake: findings of a randomised trial of an implementation intervention

Abstract Objective Evidence suggests that improvements to the childcare nutrition environment can have a positive impact on child dietary intake. The primary aim of the present study was to assess, relative to usual care, the effectiveness of a multi-strategy implementation intervention in improving childcare compliance with nutrition guidelines. As a secondary aim, the impact on child dietary intake was assessed. Design Parallel-group, randomised controlled trial design. The 6-month intervention was designed to overcome barriers to implementation of the nutrition guidelines that had been identified by applying the theoretical domains framework. Setting Hunter New England region, New South Wales, Australia. Subjects Forty-five centre-based childcare services. Results There were no differences between groups in the proportion of services providing food servings (per child) compliant with nutrition guideline recommendations for all five (5/5) food groups at follow-up (i.e. full compliance). Relative to control services, intervention services were more likely to be compliant with guidelines (OR; 95 % CI) in provision of fruit (10·84; 1·19, 551·20; P=0·0024), meat and meat alternatives (8·83; 1·55, –; P=0·023), dairy (8·41; 1·60, 63·62; P=0·006) and discretionary foods (17·83; 2·15, 853·73; P=0·002). Children in intervention services consumed greater servings (adjusted difference; 95 % CI) of fruit (0·41; 0·09, 0·73; P=0·014) and vegetables (0·70; 0·33, 1·08; P<0·001). Conclusions Findings indicate that service-level changes to menus in line with dietary guidelines can result in improvements to children’s dietary intake. The study provides evidence to advance implementation research in the setting as a means of enhancing child public health nutrition.
INGESTED NITRATE AND NITRITE 235 3 . Studies of Cancer in Experimental Animals

3.1 Nitrate 3.1. 1 Mouse Oral administration In a study of the effects of concurrent administration of sodium nitrate and piperazine, one group of 40 male strain A mice, 7–9 weeks of age, was given 12.3 g/L sodium nitrate in the drinking-water for 25 weeks and was killed 13 weeks later. Controls were untreated. Other groups were fed piperazine (18.75 g/kg) alone in the diet or received piperazine and nitrate. The incidence of lung adenomas did not differ statistically between the sodium nitrate-treated mice (7/40), untreated controls (12/37), mice fed piperazine alone (7/33) or mice fed piperazine and treated with nitrate (15/37). The authors noted that less than 2.5% of the administered nitrate was reduced to nitrite in vivo in mice (Greenblatt & Mirvish, 1973). Groups of 10 male and 10 female ICR mice, 8 weeks of age, were fed an experimental diet containing 0, 2.5 or 5.0% sodium nitrate for 2 years. No significant differences in food intake, body weight or tumour incidence were observed between untreated control and treated animals (Sugiyama et al., 1979). [The Working Group noted the small number of animals per group. ] Groups of 100 female NMRI mice, weighing 27–31 g, were given drinking-water that contained 0, 100 or 1000 mg/L (0, 30 or 300 mg/kg body weight (bw)) calcium nitrate daily for 18 months. Survival of the high-dose group was lower than that of controls. No increase in tumour incidence was observed in the nitrate-treated groups (Mascher & Marth, 1993). 3.1. 2 Rat Oral administration Groups of 15 male and 15 female MRC-derived rats, 8–10 weeks of age, were given 0 or 5 g/L sodium nitrate in the drinking-water for 84 weeks and served as controls in a study of nitrilotriacetic acid. The animals were killed 20 weeks later. Tumour incidences did not differ between nitrate-treated males and females and the untreated control groups (Lijinsky et al., 1973a). [The Working Group noted the short duration of exposure. ] Groups of 10 male Sprague-Dawley rats, 2 months of age, received 0 or 4000 mg/L sodium nitrate in the drinking-water for 14 months. Body weights of the nitrate-treated group were lower than those of untreated controls. The nitrate-treated rats had a higher incidence of lung lesions compared with controls (4/4 versus 1/5). The nature of lung lesions was not described (Chow et al., 1980). [The Working Group noted the small
Improvisation and Performance in Software Development Teams : The Role of Geographic Dispersion

Software development teams are increasingly faced with unanticipated obstacles to effectiveness that require extemporaneous actions. Team improvisation has been identified as an important team situated response to emergent challenges to team effectiveness. However, the efficacy of team improvisation is not well understood in the context of software development teams—which perform complex, knowledge intensive tasks. We examine the efficacy of team improvisation in enhancing team effectiveness and identify team geographic dispersion as an important boundary condition. We test our hypotheses using data from 299 team leaders and members belonging to 71 teams. We find that team improvisation positively affects team performance, and that the degree of team geographic dispersion moderates the relationship between improvisation and team effectiveness. Theoretical and practical implications are offered.
Biblical Foundationalism and Religious Reflection: Polarization of Faith and Intellect Oriented Epistemologies within a Christian Ideological Surround

Among other things, the Ideological Surround Model (ISM) argues that greater objectivity can be achieved through an empiricism that brings emic religious and etic social scientific perspectives into formal dialog. In this project, 421 undergraduates responded to a Christian Religious Reflection Scale along with an etic Religious Fundamentalism and an emic Biblical Foundationalism scale. Christian Religious Reflection proved to be polarized with Faith and Intellect Oriented factors correlating negatively. Faith Oriented Reflection, Religious Fundamentalism, and Biblical Foundationalism displayed negative linkages with Quest and Openness to Experience. Intellect Oriented Reflection was incompatible with Christian commitments and predicted higher Quest and Openness to Experiences. Statistical controls for the etic language of Religious Fundamentalism demonstrated that the emic language of Biblical Foundationalism could support both Faith and Intellect Oriented epistemologies and was not incompatible with Quest or Openness to Experience. Participants displayed higher scores on Biblical Foundationalism than on Religious Fundamentalism. These data illustrated how a dialogical empiricism can promote objectivity.
Post‐Tonsillectomy bleeding: An evaluation of risk factors

While tonsillectomy is usually a safe operation, it is always accompanied by the risk of immediate postoperative bleeding. Despite continued efforts to eliminate this problem, it remains a persistent risk. In reviewing 775 consecutive cases of tonsillectomy, immediate postoperative bleeding occurred in 21 (2.7%). Diagnostic, demographic, hematologic, hemodynamic and surgical management factors were evaluated. The role of local anesthesia for tonsillectomy was also examined. Postoperative bleeders were more likely to have abnormal preoperative clotting studies, greater elevations of their mean postoperative blood pressures, and unusual surgical indications. Local anesthetic cases were, shorter, had less intraoperative bleeding and were not associated with greater postoperative bleeding. We conclude that local anesthesia is safe and efficient and that identifiable factors are associated with primary post‐tonsillectomy bleeding. An awareness of these factors can help identify potential postoperative bleeders.
Cognitive Performance in a Subclinical Obsessive-Compulsive Sample 1: Cognitive Functions

Individuals who are not clinically diagnosed with obsessive-compulsive disorder (OCD) but still display obsessive-compulsive (OC) tendencies may show cognitive impairments. The present study investigated whether there are subgroups within a healthy group showing characteristic cognitive and emotional performance levels similar to those found in OCD patients and whether they differ from OCD subgroups regarding performance levels. Of interest are those cases showing subclinical symptomatology. The results revealed no impairments in the subclinical OC participants on the neuropsychological tasks, while evidence suggests that there exist high and low scores on two standardised clinical instruments (Yale-Brown Obsessive Compulsive Scale and Cognitive Assessment Instrument of Obsessions and Compulsions) in a healthy sample. OC symptoms may diminish the quality of life and prolong sustainable return to work. It may be that occupational rehabilitation programmes are more effective in rectifying subclinical OC tendencies compared to the often complex symptoms of diagnosed OCD patients. The relationship between cognitive style and subclinical OC symptoms is discussed in terms of how materials and information might be processed. Although subclinical OC tendencies would not seem to constitute a diagnosis of OCD, the quality of treatment programmes such as cognitive behavioural therapy can be improved based on the current investigation.
Investigation of the histological development of the frontal ganglion in Locusta migratoria L. 1758 (Orthoptera, Acrididae)

The frontal ganglion plays a critical role in insect feeding and molting-related behaviors. It is present in all insect orders at all developmental stages. In this study, the histological development of the frontal ganglion of Locusta migratoria, the African migratory locust, was investigated. Ganglia were dissected at 3 distinct developmental stages and their histological structure was evaluated at the light microscope level. The development of the cells generating the ganglion in the first and fifth nymphal stages and in adults was determined using the variance analysis method. Total width and length of the ganglion cells as well as width and length of the nucleus were measured. A significant expansion of the cell and nucleus diameter was observed during development from the youngest stage toward adulthood.
Improved Aqueous Solubility and Antihypercholesterolemic Activity of Ezetimibe on Formulating with Hydroxypropyl-β-Cyclodextrin and Hydrophilic Auxiliary Substances

The purpose of this study was to improve the aqueous solubility, dissolution, and pharmacodynamic properties of a BCS class II drug, ezetimibe (Eze) by preparing ternary cyclodextrin complex systems. We investigated the potential synergistic effect of two novel hydrophilic auxiliary substances, d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) and l-ascorbic acid-2-glucoside (AA2G) on hydroxypropyl-β-cyclodextrin (HPBCD) solubilization of poorly water-soluble hypocholesterolemic drug, Eze. In solution state, the binary and ternary systems were analyzed by phase solubility studies and Job’s plot. The solid complexes prepared by freeze-drying were characterized by Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), nuclear magnetic resonance (NMR), and scanning electron microscopy (SEM). The log P values, aqueous solubility, dissolution, and antihypercholesterolemic activity of all systems were studied. The analytical techniques confirmed the formation of inclusion complexes in the binary and ternary systems. HPBCD complexation significantly (p < 0.05) reduced the log P and improved the solubility, dissolution, and hypocholesterolemic properties of Eze, and the addition of ternary component produced further significant improvement (p < 0.05) even compared to binary system. The remarkable reduction in log P and enhancement in solubility, dissolution, and antihypercholesterolemic activity due to the addition of TPGS or AA2G may be attributed to enhanced wetting, dispersibility, and complete amorphization. The use of TPGS or AA2G as ternary hydrophilic auxiliary substances improved the HPBCD solubilization and antihypercholesterolemic activity of Eze.
Getting To Know Third-Graders.

Using 400 autobiographical accounts offered by third graders, this study examined children's inner lives. Subjects were a stratified (by gender and by ethnicity at each school) random sample from eight elementary schools in a large urban Midwestern school district. The autobiographical sample analyzed consisted of information from 144 African American students (86 female and 58 male), 46 Caucasian students (32 female and 14 male), and 11 Hispanic students (7 female and 4 male). Findings include the following: (1) children want to do well in school--girls especially associate a sense of accomplishment with academics: (2) Hispanic and Caucasian students associated more negative thoughts with school more so than did African American students; (3) self-esteem seemed not to be an issue since most students would not change themselves or their family and self-esteem is tied to academic, physical, and social competence; (4) when asked about how they might change the world, regardless of race, students hoped to decrease violence; (5) students expressed a need fr their own personal space at home; (6) family concerns were greatest among Hispanic students; (7) students were most afraid of death; and (8) students regarded math and language arts as being most important to their future; and finally, (9) students' goals were fairly well-defined with sports being in the future for all except the girls who envisioned themselves in the arts. Contains 17
Self-Configuring and Optimizing Mobile Ad Hoc Networks

We present he design and implementation of a working system that enables self-configuration and self-optimization in mobile ad hoc networks (MANETs) by exploiting context awareness and cross-layer design principles, combined with simple network management policies and network programmability. We propose the collaborative management of the MANET through a proactively constructed body of nodes in order to overcome the inherently dynamic nature of MANETs
In Vivo Identification of Solar Radiation-Responsive Gene Network: Role of the p38 Stress-Dependent Kinase

Solar radiation is one of the most common threats to the skin, with exposure eliciting a specific protective cellular response. To decrypt the underlying mechanism, we used whole genome microarrays (Agilent 44K) to study epidermis gene expression in vivo in skin exposed to simulated solar radiation (SSR). We procured epidermis samples from healthy Caucasian patients, with phototypes II or III, and used two different SSR doses (2 and 4 J/cm2), the lower of which corresponded to the minimal erythemal dose. Analyses were carried out five hours after irradiation to identify early gene expression events in the photoprotective response. About 1.5% of genes from the human genome showed significant changes in gene expression. The annotations of these affected genes were assessed. They indicated a strengthening of the inflammation process and up-regulation of the JAK-STAT pathway and other pathways. Parallel to the p53 pathway, the p38 stress-responsive pathway was affected, supporting and mediating p53 function. We used an ex vivo assay with a specific inhibitor of p38 (SB203580) to investigate genes the expression of which was associated with active p38 kinase. We identified new direct p38 target genes and further characterized the role of p38. Our findings provide further insight into the physiological response to UV, including cell-cell interactions and cross-talk effects.
Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model

In pre-clinical studies, combination therapy with gemcitabine and targeted radioimmunotherapy (RIT) using 212Pb-trastuzumab showed tremendous therapeutic potential in the LS-174T tumor xenograft model of disseminated intraperitoneal disease. To better understand the underlying molecular basis for the observed cell killing efficacy, gene expression profiling was performed after a 24 h exposure to 212Pb-trastuzumab upon gemcitabine (Gem) pre-treatment in this model. DNA damage response genes in tumors were quantified using a real time quantitative PCR array (qRT-PCR array) covering 84 genes. The combination of Gem with α-radiation resulted in the differential expression of apoptotic genes (BRCA1, CIDEA, GADD45α, GADD45γ, IP6K3, PCBP4, RAD21, and p73), cell cycle regulatory genes (BRCA1, CHK1, CHK2, FANCG, GADD45α, GTSE1, PCBP4, MAP2K6, NBN, PCBP4, and SESN1), and damaged DNA binding and repair genes (BRCA1, BTG2, DMC1, ERCC1, EXO1, FANCG, FEN1, MSH2, MSH3, NBN, NTHL1, OGG1, PRKDC, RAD18, RAD21, RAD51B, SEMA4G, p73, UNG, XPC, and XRCC2). Of these genes, the expression of CHK1, GTSE1, EXO1, FANCG, RAD18, UNG and XRCC2 were specific to Gem/212Pb-trastuzumab administration. In addition, the present study demonstrates that increased stressful growth arrest conditions induced by Gem/212Pb-trastuzumab could suppress cell proliferation possibly by up-regulating genes involved in apoptosis such as p73, by down-regulating genes involved in cell cycle check point such as CHK1, and in damaged DNA repair such as RAD51 paralogs. These events may be mediated by genes such as BRCA1/MSH2, a member of BARC (BRCA-associated genome surveillance complex). The data suggest that up-regulation of genes involved in apoptosis, perturbation of checkpoint genes, and a failure to correctly perform HR-mediated DSB repair and mismatch-mediated SSB repair may correlate with the previously observed inability to maintain the G2/M arrest, leading to cell death.
Interleukin-1 gene cluster variants in hemodialysis patients with end stage renal disease: An association and meta-analysis

We evaluated whether polymorphisms in interleukin (IL-1) gene cluster (IL-1 alpha [IL-1A], IL-1 beta [IL-1B], and IL-1 receptor antagonist [IL-1RN]) are associated with end stage renal disease (ESRD). A total of 258 ESRD patients and 569 ethnicity matched controls were examined for IL-1 gene cluster. These were genotyped for five single-nucleotide gene polymorphisms in the IL-1A, IL-1B and IL-1RN genes and a variable number of tandem repeats (VNTR) in the IL-1RN. The IL-1B − 3953 and IL-1RN + 8006 polymorphism frequencies were significantly different between the two groups. At IL-1B, the T allele of − 3953C/T was increased among ESRD (P = 0.0001). A logistic regression model demonstrated that two repeat (240 base pair [bp]) of the IL-1Ra VNTR polymorphism was associated with ESRD (P = 0.0001). The C/C/C/C/C/1 haplotype was more prevalent in ESRD = 0.007). No linkage disequilibrium (LD) was observed between six loci of IL-1 gene. We further conducted a meta-analysis of existing studies and found that there is a strong association of IL-1 RN VNTR 86 bp repeat polymorphism with susceptibility to ESRD (odds ratio = 2.04, 95% confidence interval = 1.48-2.82; P = 0.000). IL-1B − 5887, +8006 and the IL-1RN VNTR polymorphisms have been implicated as potential risk factors for ESRD. The meta-analysis showed a strong association of IL-1RN 86 bp VNTR polymorphism with susceptibility to ESRD.
Orthologous Allergens and Diagnostic Utility of Major Allergen Alt a 1

Purpose Hypersensitivity to fungi is associated with rhinoconjunctivitis and asthma. For some fungi, such as Alternaria alternata (A. alternata), the symptoms of asthma are persistent, increasing disease severity and the risk of fatal outcomes. There are a large number of species of fungi but knowledge of them remains limited. This, together with the difficulties in obtaining adequate standardized extracts, means that there remain significant challenges in the diagnosis and immunotherapy of allergy associated with fungi. The type of indoor fungi related to asthma/allergy varies according to geographic, climatic, and seasonal factors, making their study difficult. The aim of this study was to determine hypersensitivity to indoor fungi in a population from Cuenca, Spain. Methods Thirty-five patients with symptoms compatible with rhinitis or asthma who showed clear worsening of their symptoms in their homes or workplace were included. In vivo and in vitro tests were made with a battery of fungal allergens, including the species isolated in the home or workplace. Results Ulocladium botrytis (U. botrytis) and A. alternata were the most representative species as a source of home sensitization. These species showed very high concordance in skin tests, specific IgE, and histamine release. The allergen Alt a 1, which was recognized in all patients, was detected in A. alternata, U. botrytis, and Stemphylium botryosum (S. botryosum). Conclusions U. botrytis and A. alternata were the most representative species as a source of home sensitization. Alt a 1 was recognized in all patients and may be considered a non-species-specific allergen that could be used as a diagnostic source of sensitization to some species of the Pleosporaceae family.