Miracle-dz/UniFAR-FTUs huggingface dataset:
A Rare Case of Composite Dural Extranodal Marginal Zone Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Background Primary extranodal marginal zone lymphoma (MZL) of the dura is a rare neoplastic entity in the central nervous system (CNS). Methods We used literature searches to identify previously reported cases of primary dural MZL. We also reviewed clinical, pathologic, and radiographic data of an adult patient with concurrent dural MZL and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Results We identified 104 cases of dural MZL in the literature. None of them presented concurrently with another type of non-Hodgkin lymphoma. This is the first report of composite lymphoma consisting of dural MZL and CLL/SLL in the bone marrow and lymph nodes. Conclusion Primary dural MZL is a rare, indolent low-grade CNS lymphoma, with a relatively good prognosis. Its treatment is multidisciplinary and often requires surgical intervention due to brain compression, along with low to moderate doses of radiotherapy and/or systemic chemotherapy.
Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells

Hepatic arterial infusion (HAI) chemotherapy is expected to be a more effective and safer method to treat the hepatic metastasis of pancreatic cancer than intravenous (iv) administration because of higher tumor exposure and lower systemic exposure. To clarify the uptake mechanism of nucleoside anticancer drugs, including gemcitabine (GEM), in pancreatic cancer, we investigated the uptakes of radiolabeled uridine (a general substrate of nucleoside transporters) and GEM in pancreatic cancer cell lines MIA‐PaCa2 and As‐PC1. Uridine uptake was inhibited by non‐labeled GEM and also by S‐(4‐nitrobenzyl)‐6‐thioinosine (NBMPR; an inhibitor of equilibrative nucleoside transporters, ENTs) in a concentration‐dependent manner, suggesting that ENTs contribute to uridine uptake in pancreatic cancer cells. As for GEM, saturable uptake was mediated by high‐ and low‐affinity components with Km values of micromolar and millimolar orders, respectively. Uptake was inhibited in a concentration‐dependent manner by NBMPR and was sodium ion‐independent. Moreover, the concentration dependence of uptake in the presence of 0.1 μM NBMPR showed a single low‐affinity site. These results indicated that the high‐ and low‐affinity sites correspond to hENT1 and hENT2, respectively. The results indicated that at clinically relevant hepatic concentrations of GEM in GEM‐HAI therapy, the metastatic tumor exposure of GEM is predominantly determined by hENT2 under unsaturated conditions, suggesting that hENT2 expression in metastatic tumor would be a candidate biomarker for indicating anticancer therapy with GEM‐HAI.
Perceptual-Cognitive Expertise in Elite Volleyball Players

The goal of the current study was to investigate the relationship between sport expertise and perceptual and cognitive skills, as measured by the component skills approach. We hypothesized that athletes would outperform non-athlete controls in a number of perceptual and cognitive domains and that sport expertise would minimize gender differences. A total of 154 individuals (87 professional volleyball players and 67 non-athlete controls) participated in the study. Participants performed a cognitive battery, which included tests of executive control, memory, and visuo-spatial attention. Athletes showed superior performance speed on three tasks (two executive control tasks and one visuo-spatial attentional processing task). In a subset of tasks, gender effects were observed mainly in the control group, supporting the notion that athletic experience can reduce traditional gender effects. The expertise effects obtained substantiate the view that laboratory tests of cognition may indeed enlighten the sport-cognition relationship.
Socio-economic inequalities in child health: Recent evidence from India

Abstract This paper analyses the Indian National Family Health Survey (2005–2006) data to present certain broad descriptive features of child health inequalities in India and their distribution across well-defined socio-economic groups classified by gender and sector-of-origin, and their dispersal across space. This study finds that poorer sections of the population are beleaguered with ill health whether in the quest for child survival or due to anxieties pertaining to child nutrition. The concentration index value for the indicators of under-five mortality, full immunisation and underweight outcomes at the national level is calculated to be −0.159, 0.204 and −0.158, respectively. The other disturbing finding here is that there are reigning regional and gender disadvantages irrespective of the developmental status of the State. This study would not only help policymakers to recognise these persistent inequalities but also would help understand health performance at the state and regional levels thus facilitating targeting intervention.
Fluorescence-aided caries excavation

Dental caries is a bacteria-infected disease. After being illuminated by an excitation light, the by-products of oral bacteria, mainly porphyrins, can emit visible auto-fluorescence, which can be used as a marker for bacteria-infected dentin. Thus the auto-fluorescence signals have been employed as an aid for the differentiation between infected and affected dentin and monitoring caries excavation. In 2002 fluorescence-aided caries excavation (FACE) was invented as an excavation device to improve the efficiency and accuracy of caries removal.This study has investigated a recent version of FACE.
Tweezing of Magnetic and Non‐Magnetic Objects with Magnetic Fields

Although strong magnetic fields cannot be conveniently “focused” like light, modern microfabrication techniques enable preparation of microstructures with which the field gradients – and resulting magnetic forces – can be localized to very small dimensions. This ability provides the foundation for magnetic tweezers which in their classical variant can address magnetic targets. More recently, the so‐called negative magnetophoretic tweezers have also been developed which enable trapping and manipulations of completely nonmagnetic particles provided that they are suspended in a high‐magnetic‐susceptibility liquid. These two modes of magnetic tweezing are complimentary techniques tailorable for different types of applications. This Progress Report provides the theoretical basis for both modalities and illustrates their specific uses ranging from the manipulation of colloids in 2D and 3D, to trapping of living cells, control of cell function, experiments with single molecules, and more.
Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain

Capsule Comparative analysis of gene expression signatures from endometriosis and mouse models shows that CACNAα2δs calcium-channel components involved in nociception are targets for the treatment of endometriosis-associated pain. Context Differential gene expression analyses comparing endometriotic lesions to eutopic endometrium have shown that the transcription factors DLX5 and DLX6 are drastically down-regulated in the ectopic implants. These finding suggests that regulatory cascades involving DLX5/6 might be involved in the origin of endometriosis symptoms such as chronic pelvic pain. We have shown that mice in which Dlx5 and Dlx6 are selectively inactivated in the uterus present an endometrial phenotype reminiscent of endometriosis implants. Objective Identify new targets for the treatment of endometriosis. Design To better focus the search for endometriosis targets we have compared the profile of genes deregulated in normal and ectopic women endometrium to those deregulated in the uterus of normal and Dlx5/Dlx6-null mice. Settings Academic research unit and University Hospital research laboratory Animals Mice carrying a uterus-specific deletion of Dlx5/Dlx6. Interventions Analysis of archive sections from normal endometrium and endometriosis implants. Main Outcome A novel endometriosis signature suggests that α2δs subunits of voltage-gated calcium channel are targets for the management of endometriosis-associated pain. Results We identify a signature of 30 genes similarly deregulated in human endometriosis implants and in Dlx5/6-null mouse uteri reinforcing the notion that the down-regulation of Dlx5/6 is an early event in the progress of endometriosis. CACNA2D3, a component of the voltage-dependent calcium channel complex is strongly overexpressed both in endometriosis implants and in mutant mouse uteri; other members of the alfa2delta family, CACNA2D1 and CACNA2D2, are also overexpressed in endometriosis. Conclusion CACNA2D1, CACNA2D2 and CACNA2D3 are directly involved in pain perception. In particular, CACNA2D3 has been associated to pain sensitization and heat nociception in animal models while, in patients, variants of this gene are associated to reduced sensitivity to acute noxious stimuli. As CACNA2Ds are targets of gabapentinoids analgesics, our results suggest to consider the use of these drugs for the treatment of endometriosis-associated pain. Indeed, recent small-scale clinical studies have shown that gabapentin can be effective in the treatment of women chronic pelvic pain. Our findings reinforce the need for a large definitive trial.
The Ameliorative Effect of Pectin-Insulin Patch On Renal Injury in Streptozotocin-Induced Diabetic Rats

Background/Aims: Renal damage and dysfunction is attributed to sustained hyperglycaemia in overt diabetes. Subcutaneous insulin injections are beneficial in delaying the progression of renal dysfunction and damage in diabetics. However, the current mode of administration is associated with severe undesirable effects. In this study, we evaluated the ameliorative effects of pectin-insulin dermal patches on renal dysfunction in diabetes. Methods: Pectin-insulin patches (20.0, 40.8 and 82.9 µg/kg) were applied on the skin of streptozotocin-induced diabetic rats, thrice daily for 5 weeks. Blood glucose concentration, blood pressure and urine output volume were recorded on week 5 after which the animals were sacrificed after which the kidneys and plasma were collected. Kidney nephrin expression and urinary nephrin concentration, albumin excretion rate (AER), creatinine clearance (CC) and albumin creatinine ratio (ACR) were assessed. Results: Patch application resulted in reduced blood glucose concentration and blood pressure. Furthermore, pectin-insulin patch treatment resulted in increased kidney nephrin expression and reduced urinary nephrin concentration. AER, CC ACR were also reduced post patch application. Conclusions: The application of pectin-insulin patch limited diabetes associated kidney damaged and improved kidney function. These observations suggest that pectin-insulin patches may ameliorate kidney dysfunction that is associated with chronic subcutaneous insulin administration.
The pole structure of the unitary, crossing symmetric low energy ππ scattering amplitudes

The pole structure of the low energy ππ scattering amplitudes is studied using a proper chiral unitarization method combined with crossing symmetry and the low energy phase shift data. It is found that the σ pole position is at Mσ = 470±50 MeV, Γσ = 570±50 MeV. The existence of the virtual state pole in the IJ=20 channel is reconfirmed. Various threshold parameters are estimated and are found in general in good agreement with the results obtained from the Roy equation analyses.
Too Close and Crowded: Understanding Stress on Mobile Instant Messengers based on Proxemics

Nowadays, mobile instant messaging (MIM) is a necessity for our private and public lives, but it has also been the cause of stress. In South Korea, MIM stress has become a serious social problem. To understand this stress, we conducted four focus groups with 20 participants under MIM stress. We initially discovered that MIM stress relates to how people perceive the territory in MIM. We then applied proxemics-the theory of human use of space-to the thematic analysis as the rationale. The data revealed two main themes: too close and too crowded. The participants were stressed due to design features that let strangers or crowds into their MIM applications and forced them to interact and share their status with them. Based on this finding, we propose a set of implications for designing anti-stress MIM applications.
Symmorphosis and skeletal muscle V̇O2 max : in vivo and in vitro measures reveal differing constraints in the exercise‐trained and untrained human

The concept of symmorphosis predicts that the capacity of each step of the oxygen cascade is attuned to the task demanded of it during aerobic exercise at maximal rates of oxygen consumption ( V̇O2 max ) such that no single process is limiting or in excess at V̇O2 max . The present study challenges the applicability of this concept to humans by revealing clear, albeit very different, limitations and excesses in oxygen supply and consumption among untrained and endurance‐trained humans. Among untrained individuals, V̇O2 max is limited by the capacity of the mitochondria to consume oxygen, despite an excess of oxygen supply, whereas, among trained individuals, V̇O2 max is limited by the supply of oxygen to the mitochondria, despite an excess of mitochondrial respiratory capacity.
Fireplug: Flexible and robust N-version geo-replication of graph databases

The paper describes and evaluates Fireplug, a flexible architecture to build robust geo-replicated graph databases. Fireplug can be configured to tolerate from crash to Byzantine faults, both within and across different datacenters. Furthermore, Fireplug is robust to bugs in existing graph database implementations, as it allows to combine multiple graph databases instances in a cohesive manner. Thus, Fireplug can support many different deployments, according to the performance/robustness tradeoffs imposed by the target application. Our evaluation shows that Fireplug can implement Byzantine fault tolerance in geo-replicated scenarios and still outperform the built-in replication mechanism of Neo4j, which only supports crash faults.
A Conditional Information Inequality and Its Combinatorial Applications

We show that the inequality <inline-formula> <tex-math notation="LaTeX">$H(A | B,X) + H(A | B,Y) \leqslant H(A | B)$ </tex-math></inline-formula> for jointly distributed random variables <inline-formula> <tex-math notation="LaTeX">$A,B,X,Y$ </tex-math></inline-formula>, which does not hold in general case, holds under some natural condition on the support of the probability distribution of <inline-formula> <tex-math notation="LaTeX">$A,B,X,Y$ </tex-math></inline-formula>. This result generalizes a version of the conditional Ingleton inequality: if for some distribution <inline-formula> <tex-math notation="LaTeX">$I(X \mskip 5mu {:} \mskip 5mu Y | A) = H(A | X,Y)=0$ </tex-math></inline-formula>, then <inline-formula> <tex-math notation="LaTeX">$I(A \mskip 5mu {:} \mskip 5mu B) \leqslant I(A \mskip 5mu {:} \mskip 5mu B | X) + I(A \mskip 5mu {:} \mskip 5mu B | Y) + I(X \mskip 5mu {:} \mskip 5mu Y)$ </tex-math></inline-formula>. We present two applications of our result. The first one is the following easy-to-formulate theorem on edge colorings of bipartite graphs: assume that the edges of a bipartite graph are colored in <inline-formula> <tex-math notation="LaTeX">$K$ </tex-math></inline-formula> colors so that each two edges sharing a vertex have different colors and for each pair (left vertex <inline-formula> <tex-math notation="LaTeX">$x$ </tex-math></inline-formula>, right vertex <inline-formula> <tex-math notation="LaTeX">$y$ </tex-math></inline-formula>) there is at most one color <inline-formula> <tex-math notation="LaTeX">$a$ </tex-math></inline-formula> such both <inline-formula> <tex-math notation="LaTeX">$x$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$y$ </tex-math></inline-formula> are incident to edges with color <inline-formula> <tex-math notation="LaTeX">$a$ </tex-math></inline-formula>; assume further that the degree of each left vertex is at least <inline-formula> <tex-math notation="LaTeX">$L$ </tex-math></inline-formula> and the degree of each right vertex is at least <inline-formula> <tex-math notation="LaTeX">$R$ </tex-math></inline-formula>. Then <inline-formula> <tex-math notation="LaTeX">$K \geqslant LR$ </tex-math></inline-formula>. The second application is a new method to prove lower bounds for biclique cover of bipartite graphs.
No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression

Neuroimaging research implicates the hippocampus in the aetiology of major depressive disorder (MDD). Imaging genetics studies have investigated the influence of the serotonin transporter‐linked polymorphic region (5HTTLPR) and brain‐derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD). However, conflicting results have led to inconclusive evidence about the effect of 5HTTLPR or BDNF on hippocampal volume (HCV). We hypothesized that analysis methods based on three‐dimensional (3D) hippocampal shape mapping could offer improved sensitivity to clarify these effects. Magnetic resonance imaging data were collected in parallel samples of 111 healthy individuals and 84 MDD patients. Manual hippocampal segmentation was conducted and the resulting data used to investigate the influence of 5HTTLPR and BDNF Val66Met genotypes on HCV and 3D shape within each sample. Hippocampal volume normalized by intracranial volume (ICV) showed no significant difference between 5HTTLPR S allele carriers and L/L homozygotes or between BDNF Met allele carriers and Val/Val homozygotes in the group of healthy individuals. Moreover, there was no significant difference in normalized HCV between 5HTTLPR diallelic and triallelic classifications or between the BDNF Val66Met genotypes in MDD patients, although there was a relationship between BDNF Val66Met and ICV. Shape analysis detected dispersed between‐group differences, but these effects did not survive multiple testing correction. In this study, there was no evidence of a genetic effect for 5HTTLPR or BDNF Val66Met on hippocampal morphology in either healthy individuals or MDD patients despite the relatively large sample sizes and sensitive methodology.
Asphalt mixtures with a high amount of RAP – case study

A case study of one trial section in the Pilsen region is presented. The pavement in the section was newly constructed in 2015 using one type of an asphalt concrete mixtures with varying RAP content. The constructed surface course comprises of 0% to 50% RAP. In order to restore the aged binder properties and to avoid the embrittlement of the produced mixtures, a rubber-based modifier/rejuvenator was employed. For technological reasons during manufacturing processes, which engage a parallel drying drum, a crude oil-based rejuvenator was also added. This article contains the preliminary data from an on-going project focused on monitoring the properties of bituminous binders contained in asphalt mixtures. The actual bituminous binders were extracted straight after production, after 6 months and after 12 months. The binder characteristics are evaluated using empirical testing as well as functional tests. Low temperature properties are measured by a Bending Beam Rheometer (BBR). The preliminary results show, that the bituminous binders properties change significantly in a relatively short period of time. The progress in binder’ characteristics is contradictory to up-to date knowledge. The probability that the phenomenon of diffusion between aged binder and rejuvenator agents occurs exists. Moreover, the data might indicate that the process of rejuvenator evaporation takes place.
Early‐onset pneumonia after liver transplantation: Microbiological findings and therapeutic consequences

Early‐onset hospital‐acquired pneumonia (E‐HAP) is one of the leading causes of sepsis and mortality after liver transplantation (LT). The appropriate antimicrobial therapy is crucially important for surviving sepsis in this context. The aim of this study was to analyze microbiological findings, associated factors, and optimal antibiotic regimens for E‐HAP after LT. Patients demonstrating E‐HAP in a single‐center cohort of 148 LT recipients were prospectively detected. The diagnosis of pneumonia relied on a combination of supportive clinical findings and a positive culture of a lower respiratory tract sample. E‐HAP was considered present if pneumonia occurred within 6 days of intensive care unit (ICU) admission after LT. Twenty‐three patients (15.5%) developed E‐HAP, which were caused by 36 pathogens (61.1% were gram‐negative bacilli, and 33.3% were classified as hospital‐acquired). For patients who developed E‐HAP, the duration of mechanical ventilation and the ICU stay were significantly longer. Despite a trend toward higher mortality at any time in the E‐HAP group, there was no significant difference in mortality between patients with E‐HAP and patients without E‐HAP. Lactatemia, vasopressor requirements, Simplified Acute Physiology Score II (SAPS II) score on ICU admission, and mechanical ventilation lasting more than 48 hours after LT were associated with E‐HAP. Combinations of broad‐spectrum β‐lactams and aminoglycosides were active against more than 91% of the encountered pathogens. However, antibiotic de‐escalation was possible in more than one‐third of cases after identification of the pathogens. In conclusion, E‐HAP after LT is a severe condition that appears to be influenced by physiological derangements induced by the surgery, such as lactatemia, vasopressor requirements, and mechanical ventilation requirements, as well as the postoperative SAPS II score. At the time of treatment initiation, an antimicrobial regimen usually proposed for late‐onset pneumonia should be followed. Liver Transpl 16:1178–1185, 2010. © 2010 AASLD.
Entrepreneurship and the Socio-Technical Chasm in a Lean Economy

Online technologies are increasingly hailed as enablers of entrepreneurship and income generation. Recent evidence suggests, however, that even the best such tools disproportionately favor those with pre-existing entrepreneurial advantages. Despite intentions, the technology on its own seems far from addressing socio-economic inequalities. Using participatory action research, we investigated why this might be, in an intimate, close-up context. Over a 1-year period, we--a collaborative team of university researchers and residents of Detroit's East Side--worked to establish a neighborhood tour whose initial goal was to raise supplementary income and fundraise for community block clubs. We found that in addition to technical requirements, such as communication tools, a range of non-technological efforts is needed to manage projects, build self-efficacy, and otherwise support community participants. Our findings widen Ackerman's "socio-technical gap" for some contexts and offer a counterpoint to overgeneralized claims about well-designed technologies being able to address certain classes of social challenges.
Validation of an Embedded-Atom Copper Classical Potential via Bulk and Nanostructure Simulations

The validation of classical potentials for describing multicomponent materials in complex geometries and their high temperature structural modifications (disordering and melting) requires to verify both a faithful description of the individual phases and a convincing scheme for the mixed interactions, like it is the case of the embedded atom scheme. The present paper addresses the former task for an embedded atom potential for copper, namely the widely adopted parametrization by Zhou, through application to bulk, surface and nanocluster systems. It is found that the melting point is underestimated by 200 degrees with respect to experiment, but structural and temperature-dependent properties are otherwise faithfully reproduced.