Miracle-dz/UniFAR-FTUs huggingface dataset:
Sustained Hemodynamic Effects of Intravenous Levosimendan

Background—The short-term infusion of levosimendan (Levo) improves hemodynamic function in patients with decompensated heart failure. The metabolites of Levo have a prolonged half-life, and one is hemodynamically active. The goal of this study was to determine whether the hemodynamic effects of Levo are sustained during a long-term infusion and beyond the discontinuation of drug infusion. Methods and Results—Patients with decompensated heart failure received escalating infusion rates of intravenous Levo (n=98) or placebo (n=48) for 6 hours. At the end of 6 hours, 85 of the Levo-treated patients were continued on open-label drug for a total of 24 hours, at which time they were randomized 1:1 to an additional 24 hours of Levo (n=43) or placebo (n=42). The hemodynamic effects observed at 24 hours were maintained at 48 hours in both the continuation and withdrawal groups and did not differ between groups. Although the plasma concentration of Levo decreased rapidly in the withdrawal group, concentrations of the active metabolite OR-1896 were similar in the continuation and withdrawal groups at 24 hours and increased further (3.5-fold to 4-fold) and to a similar extent in both groups at 48 hours. Conclusions—The hemodynamic effects of Levo were maintained during a 48-hour continuous infusion and for at least 24 hours after discontinuation of a 24-hour infusion. The active metabolite OR-1896 increased for at least 24 hours after cessation of drug infusion and may account for the prolonged hemodynamic effects of Levo.
Knowledge of and Attitude Toward Repetitive Transcranial Magnetic Stimulation Among Psychiatrists in Saudi Arabia

Objectives The aims of this study were to assess psychiatrists' knowledge of and attitudes toward repetitive transcranial magnetic stimulation (rTMS) in Saudi Arabia and to determine the contributing factors. Methods A quantitative observational cross-sectional study was conducted using an online survey. The sample consisted of 96 psychiatrists in Saudi Arabia. A new valid and reliable questionnaire was developed. Results A total of 96 psychiatrists enrolled in the study, 81% of whom were men. Half of the participants were consultants. The sample mainly consisted of general psychiatrists (65%). The mean age of the participants was 37 years. The results showed that 80% of the psychiatrists had a sufficient level of knowledge about rTMS. Consultants had greater knowledge than residents. Training abroad was not significantly associated with the level of knowledge or the type of attitude. Most psychiatrists (79%) had a positive attitude toward rTMS. Only 53% of the psychiatrists said they would agree to receive rTMS if they experienced a psychotic depressive condition. A minority of psychiatrists (7%) said they would not refer their patients for rTMS. Conclusions Most of the psychiatrists surveyed had good knowledge of and a positive attitude toward rTMS. Those who had a high level of training and experience showed higher levels of knowledge. Articles were reported to be a better source for improving physician knowledge than textbooks. Having a family member or relative who was treated with rTMS positively affected psychiatrists' attitudes toward rTMS.
Foraging bumblebees avoid flowers already visited by conspecifics or by other bumblebee species

Honey bees, Apis mellifera, use short-lived repellent scent marks to distinguish and reject flowers that have recently been visited by themselves or by siblings, and so save time that would otherwise be spent in probing empty flowers. Conversely, both honey bees and bumblebees, Bombus spp. , can mark rewarding flowers with scent marks that promote probing by conspecifics. We examined detection of recently visited flowers in a mixed community of bumblebees foraging on comfrey, Symphytum officinale, in southern England. When foraging among inflorescences on a plant, three abundant species of Bombus probed fewer inflorescences more than once than would be expected from random foraging. Bees frequently encountered inflorescences but departed without probing them for nectar. Examination of the incidence of such rejections in the two most common species, B. terrestris and B. pascuorum, revealed that the low incidence of multiple probing visits was due to two factors: bees both foraged systematically and selectively rejected inflorescences that they had previously visited. When presented with inflorescences of known history, bees selectively rejected those that had been recently visited by themselves or by conspecifics compared with randomly selected inflorescences. They were also able to distinguish inflorescences that had been visited by other Bombus species. Bees were unable to distinguish and reject inflorescences from which the nectar had been removed artificially. We conclude that these Bombus species are probably using scent marks left by previous visitors. The significance of deposition and detection of interspecific scent marks for competitive interactions between species is discussed. Copyright 1998 The Association for the Study of Animal Behaviour.
Recent developments in the molecular discrimination of formae speciales of Fusarium oxysporum.

Rapid and reliable detection and identification of potential plant pathogens is required for taking appropriate and timely disease management measures. For many microbial species of which all strains generally are plant pathogens on a known host range, this has become quite straightforward. However, for some fungal species this is quite a challenge. One of these is Fusarium oxysporum Schlechtend:Fr. , which, as a species, has a very broad host range, while individual strains are usually highly host-specific. Moreover, many strains of this fungus are non-pathogenic soil inhabitants. Thus, with regard to effective disease management, identification below the species level is highly desirable. So far, the genetic basis of host specificity in F. oxysporum is poorly understood. Furthermore, strains that infect a particular plant species are not necessarily more closely related to each other than to strains that infect other hosts. Despite these difficulties, recently an increasing number of studies have reported the successful development of molecular markers to discriminate F. oxysporum strains below the species level.
Spatial variation in N 2 -fixation rate and diazotroph activity in the Tropical Atlantic

Abstract. A variety of N2-fixers occur in oligotrophic waters and these diazotrophs make a substantial contribution to the nitrogen budget of the upper water column. A synthesis of previously published and new rate measurements for the North Atlantic provides insight into the role of two different groups of N2-fixers (Trichodesmium and small diazotrophs) in supporting N2 fixation in the tropical Atlantic. The highest rates of N2 fixation occurred in the western part of the basin, but the full data set showed no significant difference between the eastern and western parts of the basin in overall rates of N2-fixation by the two groups of diazotrophs. N2-fixation by Trichodesmium was strongly dominant in the western part of the basin while small diazotrophs played a much larger role to the east of 40° W. The reasons for this shift in dominance are unclear, as is the identity of the small organisms fixing N2 in the water column.
Web of Things-Based Remote Monitoring System for Coal Mine Safety Using Wireless Sensor Network

Frequent accidents have occurred in coal mine enterprises; therefore, raising the technological level of coal mine safety monitoring systems is an urgent problem. Wireless sensor networks (WSN), as a new field of research, have broad application prospects. This paper proposes a Web of Things- (WoT-) based remote monitoring system that takes full advantage of wireless sensor networks in combination with the CAN bus communication technique that abstracts the underground sensor data and capabilities into WoT resources to offer services using representational state transfer (REST) style. We also present three different implemented scenarios forWoT-basedremotemonitoringsystemsforcoalminesafety,forwhichthesystemperformancehasbeenmeasuredandanalyzed.Finally,wedescribeourconclusionsandfuturework.
Recurrent Neural Associative Learning of Forward and Inverse Kinematics for Movement Generation of the Redundant PA-10 Robot

We present a connectionist approach to learn forward and redundant inverse kinematics in a single recurrent network. The network architecture extends the reservoir computing idea, i.e. to read out the state of a fixed dynamic system, into an associative setting, which learns the forward and backward mapping simultaneously. For output learning we use efficient Backpropagation-Decorrelation learning while the recurrent dynamics is adjusted by an unsupervised biologically inspired learning rule based on intrinsic plasticity. Including linear connections between input and output allows to train the network for autonomous movement generation. We show results for the 7-DOF redundant PA-10 robot arm in simulation.
Electrocardiographic Findings in 122,043 Individuals

Electrocardiograms on 122,043 apparently healthy male subjects aged 16 years to over 50 years have been studied. Of this group 5,773 subjects (4.72 per cent) had electrocardiographic abnormalities. The more common abnormalities were expressed in terms of rate per thousand subjects for each 5-year age group. This provides a means of relating incidence to age. Each abnormality and its clinical significance is discussed. In 54,668 subjects incidental findings such as notched P waves, amplitude, and wave forms were tabulated.
Gamma-ray bursts spectral correlations and their cosmological use

The correlations involving the long-gamma-ray bursts (GRBs) prompt emission energy represent a new key to understand the GRB physics. These correlations have been proved to be the tool that makes long-GRBs a new class of standard candles. Gamma Ray Bursts, being very powerful cosmological sources detected in the hard X-ray band, represent a new tool to investigate the Universe in a redshift range, which is complementary to that covered by other cosmological probes (SNIa and CMB). A review of the , , and correlations is presented. Open issues related to these correlations (e.g. presence of outliers and selection effects) and to their use for cosmographic purposes (e.g. dependence on model assumptions) are discussed. Finally, the relevance of thermal components in GRB spectra is discussed in the light of some of the models recently proposed for the interpretation of the spectral-energy correlations.
Determinants of Long-Term Care Services among the Elderly: A Population-Based Study in Taiwan

Objectives The aim of the study was to investigate determinants of long-term care use and to clarify the differing characteristics of home/community-based and institution-based services users. Design Cross-sectional, population-based study. Setting Utilizing data from the 2005 National Health Interview Survey conducted in Taiwan. Participants A national sample of 2,608 people (1,312 men, 1,296 women) aged 65 and older. Measurements The utilization of long-term care services (both home/community- and institution-based services) was measured. A χ2 analysis tested differences in baseline characteristics between home/community-based and institution-based long-term care users. The multiple-logistic model was adopted with a hierarchical approach adding the Andersen model’s predisposing, enabling, and need factors sequentially. Multiple logistic models further stratified data by gender and age. Results Compared with users of home/community-based care, those using institution-based care had less education (p = 0.019), greater likelihood of being single (p = 0.001), fewer family members (p = 0.002), higher prevalence of stool incontinence (p = 0.011) and dementia (P = .025), and greater disability (p = 0.016). After adjustment, age (compared with 65–69 years; 75–79 years, odds ratio [OR] = 2.08, p = 0.044; age ≥80, OR = 3.30, p = 0.002), being single (OR = 2.16, p = 0.006), urban living (OR = 1.68, p = 0.037), stroke (OR = 2.08, p = 0.015), dementia (OR = 2.32, p = 0.007), 1–3 items of activities of daily living (ADL) disability (OR = 5.56, p<0.001), and 4–6 items of ADL disability (OR = 21.57, p<0.001) were significantly associated with long-term care use. Conclusion Age, single marital status, stroke, dementia, and ADL disability are predictive factors for long-term care use. The utilization was directly proportional to the level of disability.
Classification of rigid and deformable objects using a novel tactile sensor

In this paper, we present a novel tactile-array sensor for use in robotic grippers based on flexible piezoresistive rubber. We start by describing the physical principles of piezoresistive materials, and continue by outlining how to build a flexible tactile-sensor array using conductive thread electrodes. A real-time acquisition system scans the data from the array which is then further processed. We validate the properties of the sensor in an application that classifies a number of household objects while performing a palpation procedure with a robotic gripper. Based on the haptic feedback, we classify various rigid and deformable objects. We represent the array of tactile information as a time series of features and use this as the input for a k-nearest neighbors classifier. Dynamic time warping is used to calculate the distances between different time series. The results from our novel tactile sensor are compared to results obtained from an experimental setup using a Weiss Robotics tactile sensor with similar characteristics. We conclude by exemplifying how the results of the classification can be used in different robotic applications.
Nonlinear constrained tracking of targets on roads

Ground targets are constrained to move on the Earth's surface and are most likely to travel along a road network. For targets on road, their interaction with the environment and with each other particularly at intersections is more structured, thus useful to tracking algorithms. Indeed, the knowledge of terrain database and road maps can be used as constraints and incorporated into the tracking algorithms. In this paper, we set forth a nonlinear formulation of tracking multiple interacting targets along road networks and apply nonlinear filtering techniques (namely, the extended Kalman filter, the unscented Kalman filter, the particle filter, and a hybrid Kalman particle filter) to the problem for such scenarios as air-to-ground surveillance. Simulation results are present to illustrate the performance of the nonlinear filters with the nonlinear formulation as compared to conventional ones.
Electrophysiological Evidence of Implicit and Explicit Categorization Processes

Event-related brain potentials (ERPs), which provide on-line measures of categorization processes, were used to assess the implicit and explicit categorization of stimuli along evaluative (positive and negative) and nonevaluative (people and no-people) dimensions. Participants were exposed to stimuli that simultaneously varied along both dimensions, but were explicitly instructed to categorize along only one of them. Consistent with prior research, the late positive potential (LPP) of the ERP was sensitive to participants' explicit categorization task. However, the LPP also revealed implicit categorization along the non-task-relevant dimension. Additionally, there was evidence of an implicit negativity bias in which negative stimuli spontaneously received greater processing than positive stimuli and a people/no-people analog in which stimuli containing people received greater processing than stimuli without people. Results suggest the operation of adaptively beneficial implicit categorization processes, triggered by significant proximal stimuli, serving broad, cross-situational goals.
Wander Join: Online Aggregation via Random Walks

Joins are expensive, and online aggregation over joins was proposed to mitigate the cost, which offers users a nice and flexible tradeoff between query efficiency and accuracy in a continuous, online fashion. However, the state-of-the-art approach, in both internal and external memory, is based on ripple join, which is still very expensive and even needs unrealistic assumptions (e.g., tuples in a table are stored in random order). This paper proposes a new approach, the wander join algorithm, to the online aggregation problem by performing random walks over the underlying join graph. We also design an optimizer that chooses the optimal plan for conducting the random walks without having to collect any statistics a priori. Compared with ripple join, wander join is particularly efficient for equality joins involving multiple tables, but also supports θ-joins. Selection predicates and group-by clauses can be handled as well. Extensive experiments using the TPC-H benchmark have demonstrated the superior performance of wander join over ripple join. In particular, we have integrated and tested wander join in the latest version of PostgreSQL, demonstrating its practicality in a full-fledged database system.
Capital regulation and macroeconomic activity: Implications for macroprudential policy

This paper studies the macroeconomic effect of changes in the capital requirements set by microprudential bank regulators. The central result is that unanticipated increases in capital requirements lower lending to firms and households, reduce aggregate expenditure and raise credit spreads. A financial accelerator effect is found to amplify the macroeconomic responses to shifts in bank credit supply. Results from a counterfactual experiment that links capital requirements to house prices and mortgage spreads indicate that a counter cyclical capital buffer could be an effective macroprudential tool. The reported simulations show that tighter macroprudential policy would have lowered house prices and mortgage lending in the early 2000s, with easier monetary policy acting to offset the contractionary effects on output.
Universality in Elementary Cellular Automata

The purpose of this paper is to prove that one of the simplest one dimensional cellular automata is computationally universal, implying that many questions concerning its behavior, such as whether a particular sequence of bits will occur, or whether the behavior will become periodic, are formally undecidable. The cellular automaton we will prove this for is known as “Rule 110” according to Wolfram’s numbering scheme [2]. Being a one dimensional cellular automaton, it consists of an infinitely long row of cells "Ci # i $ ! %. Each cell is in one of the two states "0, 1%, and at each discrete time step every cell synchronously updates itself according to the value of itself and its nearest neighbors: &i, Ci ( F(Ci)1, Ci, Ci*1), where F is the following function:
Blood S-adenosylmethionine concentrations and lymphocyte methylenetetrahydrofolate reductase activity in diabetes mellitus and diabetic nephropathy.

The erythrocyte concentrations of the body's chief physiologic methyl donor S-adenosylmethionine (SAM) and of its metabolite and inhibitor S-adenosylhomocysteine (SAH), the plasma concentrations of total homocysteine (tHcy), and the activity of N(5,10) methylenetetrahydrofolate reductase (MTHFR) in lymphocytes were determined in healthy subjects and patients with diabetes mellitus without complications and at various stages of diabetic nephropathy, categorized according to the degree of progression of the disease. These groups were as follows: 1, control; 2, diabetics with no complications; 3, patients with albuminuria; 4, patients with an elevated plasma creatinine; and 5, patients on dialysis. No parameter studied exhibited significant differences between the type 1 and the type 2 diabetics. In control subjects, the blood concentrations of SAM were proportional to the activity of MTHFR; in diabetics, it was not. Consistent with previous observations, progression of nephropathy was accompanied by increased concentrations of tHcy. Increased erythrocyte concentrations of SAH, decreased erythrocyte concentrations of SAM, SAM/SAH ratios, and lymphocyte MTHFR activity also accompanied disease progression. The blood concentrations of SAH paralleled those of tHcy, while the concentrations of SAM showed a bimodal relationship with those of tHcy. These results provide further evidence that alterations in the blood concentrations of SAM and related compounds are abnormal in patients with diabetes, particularly in those with nephropathy. The deficiency of SAM may lead to methyl deficiencies, which may contribute to the high morbidity and mortality in patients with diabetic nephropathy. We have also demonstrated a decrease in lymphocyte MTHFR activity in patients with advanced nephropathy, suggesting that hyperhomocysteinemia in these patients may be due to a generalized metabolic abnormality. Further studies are needed to determine the pathogenesis of these abnormalities and whether they are present in renal failure due to causes other than diabetes or whether they are specific to diabetic nephropathy.
Environmental constraints drive the partitioning of the soundscape in fishes

Significance More and more studies stress the potential deleterious effect of anthropogenic sounds on fish acoustic communication. Paradoxically, how the communication between fishes in a community is organized remains extremely poorly known, as studies using passive acoustic recordings are typically restricted to one or two species. At a single site, we were able to follow 16 different vertebrate sounds for 15 days. We demonstrate that the fish population can be distributed into two groups: one diurnal and one nocturnal. Most interestingly, fish calling at night do not show overlap at the level of the main calling frequency, in contrast to fish calling during the day. This shows that at night, in the absence of visual cues, sound communication is more important. The underwater environment is more and more being depicted as particularly noisy, and the inventory of calling fishes is continuously increasing. However, it currently remains unknown how species share the soundscape and are able to communicate without misinterpreting the messages. Different mechanisms of interference avoidance have been documented in birds, mammals, and frogs, but little is known about interference avoidance in fishes. How fish thus partition the soundscape underwater remains unknown, as acoustic communication and its organization have never been studied at the level of fish communities. In this study, passive acoustic recordings were used to inventory sounds produced in a fish community (120 m depth) in an attempt to understand how different species partition the acoustic environment. We uncovered an important diversity of fish sounds, and 16 of the 37 different sounds recorded were sufficiently abundant to use in a quantitative analysis. We show that sonic activity allows a clear distinction between a diurnal and a nocturnal group of fishes. Moreover, frequencies of signals made during the day overlap, whereas there is a clear distinction between the different representatives of the nocturnal callers because of a lack of overlap in sound frequency. This first demonstration, to our knowledge, of interference avoidance in a fish community can be understood by the way sounds are used. In diurnal species, sounds are mostly used to support visual display, whereas nocturnal species are generally deprived of visual cues, resulting in acoustic constraints being more important.