Miracle-dz/UniFAR-FTUs huggingface dataset:
Adolescents of the US National Longitudinal Lesbian Family Study: the impact of having a known or an unknown donor on the stability of psychological adjustment.

BACKGROUND The current study is based on the US National Longitudinal Lesbian Family Study (NLLFS), which was designed to document the development of the first generation of lesbian families with children conceived through donor insemination. Data were collected in five waves, first at insemination or during pregnancy, and subsequently when the index children were 2, 5, 10 and 17 years old. The study is ongoing, with a 93% retention rate to date. The purpose of the current investigation was to assess changes in psychological adjustment of the index offspring between the time that they were 10 and 17 years old (T4 and T5) and to examine the effects of having a known or an as-yet-unknown donor. METHODS The total T5 sample consisted of 78 adolescents. The mothers in 74 families completed a Child Behaviour Checklist (CBCL) on their offspring at both T4 and T5: 26 of these offspring had been conceived through known sperm donors and 48 through unknown donors. Changes in psychological adjustment were assessed through computations of stability coefficients between T4 and T5 on all CBCL subscales, and by means of a general linear model (GLM). RESULTS On 10 out of 11 CBCL subscales, the stability coefficients were not significantly different for adolescents with known and unknown donors. Findings from the GLM showed that no main effect for donor type was found; for offspring in both donor groups thought problems and rule-breaking behaviour were higher and scores on social problems and aggressive behaviour were lower at T5 than T4. CONCLUSIONS The development of psychological well-being in the offspring of lesbian mothers over a 7-year period from childhood through adolescence is the same for those who were conceived through known and unknown donors.
Dynamic User Task Scheduling for Mobile Robots

We present our efforts to deploy mobile robots in office environments, focusing in particular on the challenge of planning a schedule for a robot to accomplish user-requested actions. We concretely aim to make our CoBot mobile robots available to execute navigational tasks requested by users, such as telepresence, and picking up and delivering messages or objects at different locations. We contribute an efficient web-based approach in which users can request and schedule the execution of specific tasks. The scheduling problem is converted to a mixed integer programming problem. The robot executes the scheduled tasks using a synthetic speech and touch-screen interface to interact with users, while allowing users to follow the task execution online. Our robot uses a robust Kinect-based safe navigation algorithm, moves fully autonomously without the need to be chaperoned by anyone, and is robust to the presence of moving humans, as well as non-trivial obstacles, such as legged chairs and tables. Our robots have already performed 15km of autonomous service tasks.
Explanation and Progress in Security Studies: Bridging Theoretical Divides in International Relations

Explanation and Progress in Security Studies asks why Security Studies, as a central area of International Relations, has not experienced scientific progress in the way natural sciences have-and answers by arguing that the underlying reason is that scholars in Security Studies have advanced a range of different notions of "explanation" or different criteria of "explanatory superiority" to show that their positions are better than rival positions. To demonstrate this, the author engages in in-depth content analysis of the generally recognized exemplars of explanation and explanatory superiority in three of the core debates in the disciplines: Why do states pursue policies of nuclear proliferation? Why do states choose to form the alliances they do? And why do liberal democratic states behave the way they do toward other liberal democracies? The book reveals that authors in the debates that have shown the most progress use similar criteria in arguing for and against the key explanations. In the nuclear proliferation debate, there is wide divergence in the criteria the most visible authors use, and there is wide divergence in the explanations offered. In the alliance formation/balance-of-power debate, there is some overlap of criteria the most important authors use, and there has been some limited movement toward consensus. In the democratic peace debate there has been much more overlap of criteria the most prominent authors use, and there is agreement on both some positive and negative conclusions.
Difficulties that elderly people encounter and their life satisfaction

The number of elderly people in Turkey is increasing. The purpose of this study was to examine the life satisfaction levels of elderly people who live in the Ankara, Kocatepe region. Most of the participants had migration experience, and an occupation, and lived in their own houses. Approximately one third of the participants had serious health problems and encountered difficulties in sustaining their daily life. Life satisfaction of the elderly who have an occupation and their own house was found to be high, but those who had health problems encountered difficulties in activities such as paying bills, performing small repairs, shopping, reading, and organizing transport. Moreover, the life satisfaction of people whose income levels were low was found to be significantly lower than for those with higher income levels.
Regulation of Murine Intestinal Inflammation by Reactive Metabolites of Oxygen and Nitrogen

Several reports have implicated reactive oxygen and nitrogen metabolites (RONS) in the initiation and/or progression of inflammatory bowel diseases (IBDs). We have investigated the role of three key RONS-metabolizing enzymes (inducible nitric oxide synthase [iNOS], superoxide dismutase [SOD], nicotinamide adenine dinucleotide phosphate [NADPH] oxidase) in a murine model of IBD. Mice genetically deficient (−/−) in either iNOS or the p47phox subunit of NADPH oxidase, transgenic (Tg) mice that overexpress SOD, and their respective wild-type (WT) littermates were fed dextran sulfate sodium (DSS) in drinking water for 7 days to induce colitis. In addition, the specific iNOS inhibitor 1400W was used in DSS-treated WT and p47phox−/− mice. WT mice responded to DSS feeding with progressive weight loss, bloody stools, elevated serum NOX and colonic mucosal injury with neutrophil infiltration. Both the onset and severity of colitis were significantly attenuated in iNOS−/− and 1400W-treated WT mice. While the responses to DSS did not differ between WT and p47phox−/− mice, enhanced protection was noted in 1400W-treated p47phox−/− mice. Interestingly, SODTg mice exhibited more severe colitis than their WT littermates. These findings reveal divergent roles for superoxide and iNOS-derived NO in intestinal inflammation.
Complications of systemic juvenile idiopathic arthritis: risk factors and management recommendations

Systemic juvenile idiopathic arthritis (SJIA) is an inflammatory condition characterized by fever, lymphadenopathy, arthritis, rash and serositis. Systemic inflammation has been associated with dysregulation of the innate immune system, suggesting that SJIA is an autoinflammatory disorder. IL-1 and IL-6 play a major role in the pathogenesis of SJIA, and treatment with IL-1 and IL-6 inhibitors has shown to be highly effective. However, complications of SJIA, including macrophage activation syndrome, limitations in functional outcome by arthritis and long-term damage from chronic inflammation, continue to be a major issue in SJIA patients’ care. Translational research leading to a profound understanding of the cytokine crosstalk in SJIA and the identification of risk factors for SJIA complications will help to improve long-term outcome.
Combining Structure‐Based Pharmacophore and In Silico Approaches to Discover Novel Selective Serotonin Reuptake Inhibitors

Inhibition of human serotonin transporter (hSERT) has been reported to be a potent strategy for the treatment for depression. To discover novel selective serotonin reuptake inhibitors (SSRIs), a structure‐based pharmacophore model (SBPM) was developed using the docked conformations of six highly active SSRIs. The best SBPM, consisting of four chemical features: two ring aromatics (RAs), one hydrophobic (HY), and one positive ionizable (PI), was further validated using Gunner‐Henry (GH) scoring and receiver operating characteristic (ROC) curve methods. This well‐validated SBPM was then used as a 3D‐query in virtual screening to identify potential hits from National Cancer Institute (NCI) database. These hits were subsequently filtered by absorption, distribution, metabolism, excretion, and toxicity (ADMET) prediction and molecular docking, and their binding stabilities were validated by 20‐ns MD simulations. Finally, only two compounds (NSC175176 and NSC705841) were identified as potential leads, which exhibited higher binding affinities in comparison with the paroxetine. Our results also suggest that cation–π interaction plays a crucial role in stabilizing the hSERT‐inhibitor complex. To our knowledge, the present work is the first structure‐based virtual screening study for new SSRI discovery, which should be a useful guide for the rapid identification of novel therapeutic agents from chemical database.
ATTITUDES OF VICTIMS AND REPEAT VICTIMS TOWARD THE POLICE : RESULTS OF THE INTERNATIONAL CRIME VICTIMS SURVEY by

Repeat victims in the West report crimes more often than other victims in order to see the offender arrested and/or to stop what is happening. Repeat victims know or assume that the same offender(s) are victimising them again and again. Repeat victims contact the police with more demanding aims than other victims. The reporting patterns of repeat victims in the West resemble those of all victims in poorer countries. Like the victims in these countries, Western repeat victims are less inclined to report at all. This finding suggests that they are less certain that the police can satisfy their needs. Repeat victims in the West do not refrain from reporting because they consider their victimisation not serious enough. They are more likely than one-time victims to refrain because they feel the police could not or would not do anything to help them. In this respect, too, they resemble victims from poorer countries. Repeat victims are less often satisfied with the police response in all regions. The differences are most pronounced among victims from industrialised countries. The reduced level of satisfaction of repeat victims with overall police performance is rooted in negative personal experiences with the police. Crime Prevention Studies, volume 12, pp. 27-52 28 — Jan J.M. van Dijk
The Decline in B Lymphopoiesis in Aged Mice Reflects Loss of Very Early B-Lineage Precursors 1

The primary age-related loss in B cell progenitors is thought to be at the pro- to pre-B cell transition. However, we show that the frequencies and absolute numbers of all progenitor populations for the B cell lineage, including B-lineage-committed pro-B cells and multipotent B-lymphoid progenitors, decline in aged C57BL/6 mice. Moreover, when derived from aged mice, lymphoid progenitors within every population examined exhibited suboptimal IL-7 responsiveness, demonstrating that age-associated suboptimal IL-7R signaling is a general property of all early B-lineage precursors. Collectively, these data indicate that aging results in a previously unappreciated decline in the earliest stages of B cell development.
Clinical symptoms according to genotype amongst patients with hereditary haemorrhagic telangiectasia

Background. Hereditary haemorrhagic telangiectasia (HHT) is a dominantly inherited disease, characterized by a wide variety of clinical manifestations, including epistaxis, gastrointestinal (GI) bleeding, pulmonary arteriovenous malformations (PAVMs) and neurological symptoms. HHT is a genetically heterogeneous disorder involving at least two loci; HHT1 mapping to chromosome 9q34.1 (ENG) and HHT2 mapping to chromosome 12q31 (ALK‐1).
Biochemical markers of bone metabolism in children with cow's milk allergy

Introduction Patients with cow's milk allergy (CMA) and following a cow milk protein-free diet for a long time are potentially at risk of developing bone abnormalities. To assess the balance between bone formation and resorption processes, we determined serum concentrations of osteocalcin (OC), bone alkaline phosphatase (BALP), C-terminal telopeptide of type I collagen (CTX), fetuin-A, osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL) in children with CMA. Material and methods The study included 50 prepubertal children with diagnosed cow's milk allergy, who were under systematic medical and nutritional care at the Institute of Mother and Child and 40 healthy counterparts as a control group. The concentrations of bone metabolism markers were determined by immunoenzymatic assays. Results The diets of all investigated children were correct in terms of phosphorus and magnesium contents but deficient in terms of calcium and vitamin D. Serum OC and CTX as well as fetuin-A concentrations were similar in both studied groups. The BALP activity was significantly (p < 0.05) higher in children with cow's milk allergy than in the controls. Serum OPG concentration was comparable in both groups, but the RANKL level was higher (p < 0.05) in CMA children than in healthy ones. Hence, the ratio of OPG/RANKL was lower in children with CMA. Conclusions Our study demonstrates slight disturbances in the profile of bone metabolism markers in growing children with CMA. The increase in RANKL level and decrease in OPG/RANKL ratio may contribute to intensification of bone resorption in these patients.
Adaptive radial rule based cubature Kalman filter

In this paper, a new adaptive cubature Kalman filter (ACKF) is proposed to improve the performance of the conventional cubature Kalman filter. The ACKF uses a new cubature rule that combines the third-degree spherical rule with the higher degree radial rule along the directions of larger uncertainty. More accurate and robust results can be achieved with slightly more points than the conventional third-degree cubature Kalman filter (CKF). Compared with the fifth-degree CKF, ACKF uses much fewer points but maintains very close performance. A target tracking benchmark problem is used to demonstrate the enhanced performance of the proposed filter.
Analisis Inklusi Keuangan dan Pemerataan Pendapatan di Indonesia

Recent study showed that increasing access and usage of banking services reduce income inequality. Nowdays banking access in Indonesia is increasing but income equality gap is widening. Therefore, by using secondary data from 33 provinces 2007- 2011, this paper aims to measure the level of access and usage for financial services across provinces in Indonesia by Index of Financial Inclusion, analyze the factors that affect financial inclusion by panel tobit regression, and describe the relationship between financial inclusion and income distribution in Indonesia. The results show that the level of financial inclusion in Indonesia is classified as low. The size of the economy and income inequality positively affect the level of financial inclusion. Opposite the research hypothesis, widening income inequality lead to higher financial inclusion in Indonesia. Moreover, the number of mobile phone and the internet user affect positively the level of financial inclusion in Indonesia. Income inequality and financial inclusion has a one-way relationship, income inequality affects financial inclusion in Indonesia but does not vice versa. Keywords : Financial Inclusion, income inequality
Strategies for Vascularization of Polymer Scaffolds

Biocompatible, degradable polymer scaffolds combined with cells or biological signals are being investigated as alternatives to traditional options for tissue reconstruction and transplantation. These approaches are already in clinical use as engineered tissues that enhance wound healing and skin regeneration. The continued enhancement of these material strategies is highly dependent on the ability to promote rapid and stable neovascularization (new blood vessel formation) within the scaffold. Whereas neovascularization therapies have shown some promise for the treatment of ischemic tissues, vascularization of polymer scaffolds in tissue engineering strategies provides a unique challenge owing to the volume and the complexity of the tissues targeted. In this article, we examine recent advances in research focused on promoting neovascularization in polymer scaffolds for tissue engineering applications. These approaches include the use of growth factors, cells, and novel surgical approaches to both enhance and control the nature of the vascular networks formed. The continued development of these approaches may lead to new tissue engineering strategies for the generation of skin and other tissues or organs.
Development of TLR inhibitors for the treatment of autoimmune diseases

Summary The innate immune system is a critical element of protection from invading pathogens. The specific receptors that recognize various components of the pathogens trigger signals that result in the production of proinflammatory cytokines as well as the activation of antigen‐presenting cells, which activate the adaptive immune system. The discovery of the Toll‐like receptors (TLRs) as important components of pathogen recognition has brought new understanding of the key signaling molecules involves in innate immune activation. Interestingly, it appears that most TLRs can recognize self‐ligands as well and that mechanisms are required to discriminate between self and non‐self ligands. One of these mechanisms is the expression of all the nucleic acid‐specific TLR in endosomal compartments and not on the cell surface. Inappropriate activation of TLRs by self‐components can result in sterile inflammation or autoimmunity. For example, TLR7 and TLR9 activation by endogenous RNA and DNA, transported to the endosomes in the form of immune complexes or non‐covalently associated with cationic peptides, could be an important mechanism involved in promoting diseases such as systemic lupus erythematosus and psoriasis. In this review, we discuss the rationale for self‐recognition by TLR7 and TLR9 as an important part of the development of lupus and other autoimmune diseases. We describe novel inhibitors of these receptors and provide evidence to support their use as novel therapeutic agents for autoimmunity.
Pyocine-typing of hospital strains of Pseudomonas pyocyanea

A method of typing Pseudomonas pyocyanea is described which makes use of the property of bacteriocine production. The method was applied in an epidemiological study of Ps. pyocyanea infection in a general hospital. It was found that the majority of strains believed on epidemiological grounds to be of common origin were allotted to the same pyocine type. In the course of this study, Ps. pyocyanea was isolated from 219 patients; 474 strains from 149 of these were typed. There was evidence of cross-infection among patients in a urogenital surgical ward, but in other parts of the hospital there appeared to be little cross-infection. A number of individual instances of auto-infection, possibly arising from the bowel flora, were seen.
Accuracy of mothers' recall of birthweight and gestational age

Summary. Information on the birthweight and gestational age of previous siblings is usually dependent upon maternal recall. This information is of importance in assessing the current risk of perinatal morbidity and mortality. The validity of maternal recall of birthweight and gestational age of 880 children born to 97 multiparas was examined by comparison with hospital records. About 75% of all reported birthweights were accurate to within 100 g and a similar proportion of reported gestational ages was correct to within 1 week. Recall was most accurate for most recent births as well as for earliest births and was not related to maternal age or education. There was a tendency for the smallness of low birthweight infants to be exaggerated by mothers. We conclude that within defined limitations, maternal recall of birthweight and gestational age of previous children is sufficiently accurate for clinical and even for epidemiological use.
Research on Internal Migration in the United States: A Survey

This study was begun while the author was on a Brookings Economic Policy Fellowship in the Office of Economic Research of the Economic Development Administration. Acknowledgements are due Paul L. Burgess, Richardj Cebula, James A. Chalmers, Herbert M. Kaufman, Todd Sandler, WalterJ Wadycki, and the referees for this journal, all of whom have made helpful comments on earlier drafts of the paper and none of whom bears any responsibility for remaining shortcomings.
Design and analysis of multiple weight linear compactors of responses containing unknown values

Occurrence of unknown values in scan chains in response to test vectors is a common phenomenon. This paper presents a method for designing matrices for linear test output compactors by using rows of multiple weights. Compared to previously proposed compactors, the method reduces the masking caused by unknowns by an order of magnitude provided that the unknowns are non-uniformally distributed among the scan chains. Also, using multiple rather than single weight compactors increases the compaction ratio and reduces the hardware overhead. The effectiveness of multiple weight compactors is demonstrated through analysis, simulations and experiments with test response from an industrial design
Gastrokine 1 Expression in the Human Gastric Mucosa Is Closely Associated with the Degree of Gastritis and DNA Methylation

Purpose Gastrokine 1 plays an important role in gastric mucosal defense. Additionally, the Gastrokine 1-miR-185-DNMT1 axis has been shown to suppress gastric carcinogenesis through regulation of epigenetic alteration. Here, we investigated the effects of Gastrokine 1 on DNA methylation and gastritis. Materials and Methods Expression of Gastrokine 1, DNMT1, EZH2, and c-Myc proteins, and the presence of Helicobacter pylori CagA protein were determined in 55 non-neoplastic gastric mucosal tissue samples by western blot analysis. The CpG island methylation phenotype was also examined using six markers (p16, hMLH1, CDH1, MINT1, MINT2 and MINT31) by methylation-specific polymerase chain reaction. Histological gastritis was assessed according to the updated Sydney classification system. Results Reduced Gastrokine 1 expression was found in 20 of the 55 (36.4%) gastric mucosal tissue samples and was closely associated with miR-185 expression. The Gastrokine 1 expression level was inversely correlated with that of DNMT1, EZH2, and c-Myc, and closely associated with the degree of gastritis. The H. pylori CagA protein was detected in 26 of the 55 (47.3%) gastric mucosal tissues and was positively associated with the expression of DNMT1, EZH2, and c-Myc. In addition, 30 (54.5%) and 23 (41.9%) of the gastric mucosal tissues could be classified as CpG island methylation phenotype-low and CpG island methylation phenotype-high, respectively. Reduced expression of Gastrokine 1 and miR-185, and increased expression of DNMT1, EZH2, and c-Myc were detected in the CpG island methylation phenotype-high gastric mucosa. Conclusions Gastrokine 1 has a crucial role in gastric inflammation and DNA methylation in gastric mucosa.