Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic Determinants of Cardiovascular Events among Women with Migraine: A Genome-Wide Association Study

Background Migraine is associated with an increased risk for cardiovascular disease (CVD). Both migraine and CVD are highly heritable. However, the genetic liability for CVD among migraineurs is unclear. Methods We performed a genome-wide association study for incident CVD events during 12 years of follow-up among 5,122 migraineurs participating in the population-based Women's Genome Health Study. Migraine was self-reported and CVD events were confirmed after medical records review. We calculated odds ratios (OR) and 95% confidence intervals (CI) and considered a genome-wide p-value <5×10−8 as significant. Results Among the 5,122 women with migraine 164 incident CVD events occurred during follow-up. No SNP was associated with major CVD, ischemic stroke, myocardial infarction, or CVD death at the genome-wide level; however, five SNPs showed association with p<5×10−6. Among migraineurs with aura rs7698623 in MEPE (OR = 6.37; 95% CI 3.15–12.90; p = 2.7×10−7) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66–9.62; p = 7.7×10−7) appeared to be associated with ischemic stroke, rs2143678 located close to MDF1 with major CVD (OR = 3.05; 95% CI 1.98–4.69; p = 4.3×10−7), and the intergenic rs1406961 with CVD death (OR = 12.33; 95% CI 4.62–32.87; p = 5.2×10−7). Further, rs1047964 in BACE1 appeared to be associated with CVD death among women with any migraine (OR = 4.67; 95% CI 2.53–8.62; p = 8.0×10−7). Conclusion Our results provide some suggestion for an association of five SNPs with CVD events among women with migraine; none of the results was genome-wide significant. Four associations appeared among migraineurs with aura, two of those with ischemic stroke. Although our population is among the largest with migraine and incident CVD information, these results must be treated with caution, given the limited number of CVD events among women with migraine and the low minor allele frequencies for three of the SNPs. Our results await independent replication and should be considered hypothesis generating for future research.
Introduction to Modern Cryptography, Second Edition

Cryptography is ubiquitous and plays a key role in ensuring data secrecy and integrity as well as in securing computer systems more broadly. Introduction to Modern Cryptography provides a rigorous yet accessible treatment of this fascinating subject. The authors introduce the core principles of modern cryptography, with an emphasis on formal definitions, clear assumptions, and rigorous proofs of security. The book begins by focusing on private-key cryptography, including an extensive treatment of private-key encryption, message authentication codes, and hash functions. The authors also present design principles for widely used stream ciphers and block ciphers including RC4, DES, and AES, plus provide provable constructions of stream ciphers and block ciphers from lower-level primitives. The second half of the book covers public-key cryptography, beginning with a self-contained introduction to the number theory needed to understand the RSA, Diffie-Hellman, and El Gamal cryptosystems (and others), followed by a thorough treatment of several standardized public-key encryption and digital signature schemes. Integrating a more practical perspective without sacrificing rigor, this widely anticipated Second Edition offers improved treatment of: Stream ciphers and block ciphers, including modes of operation and design principles Authenticated encryption and secure communication sessions Hash functions, including hash-function applications and design principles Attacks on poorly implemented cryptography, including attacks on chained-CBC encryption, padding-oracle attacks, and timing attacks The random-oracle model and its application to several standardized, widely used public-key encryption and signature schemes Elliptic-curve cryptography and associated standards such as DSA/ECDSA and DHIES/ECIES Containing updated exercises and worked examples, Introduction to Modern Cryptography, Second Edition can serve as a textbook for undergraduate- or graduate-level courses in cryptography, a valuable reference for researchers and practitioners, or a general introduction suitable for self-study.
Population-Based Sequencing of the V3-loop Can Predict the Virological Response to Maraviroc in Treatment-Naive Patients of the MERIT Trial

Background:MERIT was a randomized trial comparing maraviroc (MVC) + Combivir versus efavirenz (EFV) + Combivir in drug-naive patients screened as having R5 HIV-1 by the original Trofile assay (OTA). We retrospectively evaluated treatment response after rescreening for viral tropism using population-based V3-loop sequencing. Methods:HIV env V3-loop was amplified in triplicate using reverse transcriptase–polymerase chain reaction from stored screening plasma and sequenced. Automated base calling was performed using custom software (RECall) and tropism inferred by geno2pheno (5.75% false-positive rate). Tropism results by genotype were compared with those of OTA and Enhanced Sensitivity Trofile assay (ESTA), where all results were available (n = 876). Results:Approximately 8% of patients screened as having R5 virus by OTA were classified as having non-R5 virus by V3-loop genotyping. These patients were less likely to have early or sustained week-48 treatment response to MVC, but not EFV. When restricted to patients with R5 virus by genotype, reanalysis of the primary study endpoint (plasma viral load <50 copies/mL at week 48) showed noninferiority of MVC twice daily to EFV (67% vs. 68%). Rescreening by genotype and ESTA had 84% concordance; patients receiving MVC twice daily rescreened as having R5 virus had greater than 1 log10 copies per milliliter decrease in viral load over those rescreened as having non-R5 virus. Where genotype and ESTA screening results were discordant outcomes were similar. Conclusions:The exclusion of ∼8% of patients with CXCR4-using virus by population-based sequencing would likely have resulted in noninferior responses in the MVC twice-daily and EFV arms. Rescreening by ESTA and population-based sequencing predicted similar virological response.
Structural neuroplasticity in the sensorimotor network of professional female ballet dancers

Evidence suggests that motor, sensory, and cognitive training modulates brain structures involved in a specific practice. Functional neuroimaging revealed key brain structures involved in dancing such as the putamen and the premotor cortex. Intensive ballet dance training was expected to modulate the structures of the sensorimotor network, for example, the putamen, premotor cortex, supplementary motor area (SMA), and the corticospinal tracts. We investigated gray (GM) and white matter (WM) volumes, fractional anisotropy (FA), and mean diffusivity (MD) using magnetic resonance‐based morphometry and diffusion tensor imaging in 10 professional female ballet dancers compared with 10 nondancers. In dancers compared with nondancers, decreased GM volumes were observed in the left premotor cortex, SMA, putamen, and superior frontal gyrus, and decreased WM volumes in both corticospinal tracts, both internal capsules, corpus callosum, and left anterior cingulum. FA was lower in the WM underlying the dancers' left and right premotor cortex. There were no significant differences in MD between the groups. Age of dance commencement was negatively correlated with GM and WM volume in the right premotor cortex and internal capsule, respectively, and positively correlated with WM volume in the left precentral gyrus and corpus callosum. Results were not influenced by the significantly lower body mass index of the dancers. The present findings complement the results of functional imaging studies in experts that revealed reduced neural activity in skilled compared with nonskilled subjects. Reductions in brain activity are accompanied by local decreases in GM and WM volumes and decreased FA. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.
Diet and exercise effects on aerobic fitness and body composition in seriously mentally ill adults

Abstract Low exercise capacity and high obesity levels are the main characteristics of people with serious mental illness (SMI). We conducted a pilot study on the effects of a 3-month exercise and dietary intervention on the aerobic capacity and body composition of obese adults with SMI taking Olanzapine, a second generation antipsychotic medication known to induce weight increments. Fifty adults with SMI (15 males and 35 females) followed a 3-month weight loss intervention programme based on exercise and diet. Pre- and post-intervention, a submaximal O2 exercise test was performed in order to assess O2max anthropometric and body composition measurements were also performed. All participants were obese (body mass index (BMI): 33.61 ± 0.91 kg/m2). Pre- and post-intervention, a submaximal O2 exercise test on the treadmill was performed in order to assess O2max anthropometric and body composition measurements were also performed. Significant reductions in body weight, BMI, body fat and waist circumference were found from pre to post (p < 0.01). O2max was significantly improved in both genders (males: pre: 30.63 ± 2.06 vs. post: 33.19 ± 1.77 ml.kg−1 min−1, females: pre: 25.93 ± 1.01 vs. post: 29.51 ± 1.06 ml.kg−1 min−1, p < 0.01). A significant correlation was found between the change in O2max and the change in body weight and BMI (p < 0.05). Multiple regression analysis revealed that the relative change in O2max explained approximately 26% of the variance in the changes for both BMI (p = 0.07) and body weight (p = 0.06). A treatment of exercise and diet improves the aerobic capacity and body composition of obese adults with SMI, despite the use of Olanzapine.
Shear assessment and strengthening of reinforced concrete T-beams with externally bonded CFRP sheets

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How compilers and tools differ for embedded systems

Compiler technology includes language design, parsing, analysis, optimization, resource allocation, scheduling, and code generation. Associated tools include assemblers, linkers, debuggers, profilers, 'make', IDEs, optimized libraries, and more. While much of the technology developed over the past 50 years applies directly to embedded programming, there are key differences. Some are due to the limits of the embedded system, in particular memory size and power. Some are due to specialized architectures, such as DSPs. Others arise because of the different programming community and programming style, which is partially due to the economics of the marketplace. Here we explore some of these differences at three levels: the market, the programming environment, and the compiler.The compilers and tools marketplace for high performance workstation and cluster (HPC) systems is split between programmers and groups developing applications for internal use, and ISVs developing applications for resale. The marketplace for embedded systems is almost entirely for OEM applications, and many (or most) of the actual programmers work for the compiler vendor. This affects the forces that drive compiler and tool development and improvement.The goal for an HPC compiler is faster performance; in an embedded application, speed is not the only criterion. Getting the right mix of performance and other characteristics in an embedded system is important enough that programmers are more willing to tune the application by adjusting compiler options, performing limited rewrites, and even coding essential parts in assembler. In some instances, the target system itself is variable, and can be tuned.Focusing on just the compiler, we find many of the compiler techniques for the most performance critical embedded systems bear remarkable similarity to those used 20 or 30 years ago for the highest performance supercomputers. We also look in detail at the effectiveness of whole program analysis in both HPC and embedded compilers.
Multiple protostellar systems II. A high resolution near-infrared imaging survey in nearby star-forming regions ⋆

Context. Multiple systems are the product of protostellar core fragmentation. Studying their statistical properties in young stellar populations therefore probes the physical processes at play during star formation. Aims. Our project endeavors to obtain a robust view of multiplicity among embedded Class I and Flat Spectrum protostars in a wide array of nearby molecular clouds to disentangle "universal" from cloud-dependent processes. Methods. We have used near-infrared adaptive optics observations at the VLT through the H, Ks and Lfilters to search for tight companions to 45 Class I and Flat Spectrum protostars located in 4 different molecular clouds (Taurus-Auriga, Ophiuchus, Serpens and L1641 in Orion). We complemented these observations with published high-resolution surveys of 13 additional objects in Taurus and Ophiuchus. Results. We found multiplicity rates of 32 ± 6% and 47 ± 8% over the 45-1400 AU and 14-1400 AU separation ranges, respectively. These rates are in excellent agreement with those previously found among T Tauri stars in Taurus and Ophiuchus, and represent an excess of a factor ∼1.7 over the multiplicity rate of solar-type field stars. We found no non-hierarchical triple systems, nor any quadruple or higher-order systems. No significant cloud-to-cloud difference has been found, except for the fact that all companions to low-mass Orion protostars are found within 100 AU of their primaries whereas companions found in other clouds span the whole range probed here. Conclusions. Based on this survey, we conclude that core fragmentation always yields a high initial multiplicity rate, even in giant molecular clouds such as the Orion cloud or in clustered stellar populations as in Serpens, in contrast with predictions of numerical simulations. The lower multiplicity rate observed in clustered Class II and Class III populations can be accounted for by a universal set of properties for young systems and subsequent ejections through close encounters with unrelated cluster members.
An integral field spectroscopic survey for high redshift damped Lyman-alpha galaxies

We search for galaxy counterparts to damped Lyman-alpha absorbers (DLAs) at z>2 towards nine quasars, which have 14 DLAs and 8 sub-DLAs in their spectra. We use integral field spectroscopy to search for Ly-alpha emission line objects at the redshifts of the absorption systems. Besides recovering two previously confirmed objects, we find six statistically significant candidate Ly-alpha emission line objects. The candidates are identified as having wavelengths close to the DLA line where the background quasar emission is absorbed. In comparison with the six currently known Ly-alpha emitting DLA galaxies the candidates have similar line fluxes and line widths, while velocity offsets between the emission lines and systemic DLA redshifts are larger. The impact parameters are larger than 10 kpc, and lower column density systems are found at larger impact parameters. Assuming that a single gas cloud extends from the QSO line of sight to the location of the candidate emission line, we find that the average candidate DLA galaxy is surrounded by neutral gas with an exponential scale length of ~5 kpc.
Two alternative models of health behaviour and recovery from activity limitations due to acute injury: A prospective study

Cognitions influence recovery from activity limitations. In this study we aimed to independently test, compare and combine the common sense self-regulation model (CS-SRM) and social cognitive theory (SCT) in predicting recovery from activity limitations due to acute injury. Measures were gathered at two time points 5–6 weeks apart. The sample consisted of 146 university students (Mean age: 21.86, SD: 4.83, 62% female) with a heterogeneous range of injuries that limited their participation in physical activity. The dependent variable was recovery from activity limitations (Physical Functioning – Short Form-36). The predictor variables were measured using the Brief Illness Perception Questionnaire and SCT items designed according to theoretical recommendations. Time-line (TL) and self-efficacy (SE) were significant predictors of recovery in a multivariate analysis, controlling for reported pain at Time 1. A combined model including the best predictors from both models, TL (β = −0.25, p < 0.05, R 2 change = 0.17, p < 0.01) and SE (β =0.31, p < 0.05, R 2 change = 0.05, p < 0.05), accounted for a significant amount of the variance in recovery from activity limitations. A combination of key variables from both models may be particularly useful for understanding the cognitive factors that influence recovery from activity limitations.
Screening of Different Media and Substrates for Cultural Variability and Mass Culture of Arthrobotrys dactyloides Drechsler

Variability in growth and sporulation of five isolates of Arthrobotrys dactyloides was studied on five agar, 6 bran and 5 grain media. Potato dextrose agar (PDA) supported maximum growth of isolate A, C and E, while growth of isolate B and D was significantly lower on this medium. On Czapek’s agar and yeast glucose agar media the differentiation in the isolates in relation to growth was poor than PDA. The other two media showed much poorer differentiation. On Czapek’s agar medium, sporulation was recorded in isolate B only, whereas other isolates showed rare sporulation. Among the bran media, pea bran agar medium supported maximum growth of all the isolates except isolate B. Gram and rice bran agar media were next best. However, the growth of isolate B on the gram bran agar medium was more or less equal as other isolates. On pigeon pea bran agar medium, isolate E failed to grow while other isolates recorded poor growth. On lentil bran agar medium, only isolate B and D recorded little growth, whereas other isolates failed to grow. All the isolates recorded good sporulation on bran agar media except pigeon pea and lentil bran agar media. The grain agar media supported moderate to very good growth of all the isolates. In general isolate B remained slow growing on these media except gram grain and sorghum grain agar media on which growth of this isolate was comparable to other isolates. Sporulation in general, was good on all the grain agar media. Among different substrates screened, barley grain and pea bran were found superior to others for mass culture of isolate A of A. dactyloides.
The role of isolated Cu2+ location in structural stability of Cu-modified SAPO-34 in NH3-SCR of NO

In this study, three different methods (ion exchange, wet mixing and impregnation) were employed to prepare Cu-modified SAPO-34 molecular sieves. All these freshly prepared catalysts showed excellent activities towards the selective catalytic reduction (SCR) of NO with NH3 (NH3-SCR) no matter which preparation method was used. However, hydrothermal ageing significantly reduced the catalytic activities of those catalysts prepared by the wet-mixing and impregnation methods, respectively. The results of X-ray powder diffraction, H2-TPR and electron paramagnetic resonance measurements for these catalysts suggested that the decrease in catalytic activity may be attributed to the migration of Cu2+ ion to the centre of the hexagonal prism (site III), the formation of CuxOy and the collapse of the molecular framework during hydrothermal ageing. The degrees of structural collapse of each Cu-modified molecular sieve were different, probably due to Cu2+ species in different sites (in the ellipsoidal cavity (site I) for ion-exchange sample, near the eight-ring window (site IV) for the wet-mixing and impregnation samples). Cu2+ located at site I was more stable than that located at site IV. GRAPHICAL ABSTRACT
Analysis of the Effect of Channel Parameters between Filaments and Single Fabric Parameters on Air Permeability, Water Vapour Resistance and Thermal Resistance

The work presented is a continuation of research on the interthread channels of single fabric taking into account the parameters of fabric structure. The stereographic method of threedimensional structure analysis of a single fabric, the method of 3D microscopy of fabric fragments in structural light and analysis of microscopic images of the 4th generation were introduced. Statistical analysis of the air permeability, water vapour resistance and thermal resistance indicators for flat textile products showed significant dependences of these flow rates on channel parameters as well as other fabric parameters. The correlation between the parameters measured and the flow indicators was determined. Very strong correlations of the air permeability indicator were found with the channel clearance area, warp count and approximate channel volume. A strong correlation with the thickness of fabrics was obtained for the water vapour resistance indicator. For heat resistance there was a strong correlation with the diameter of channel inlets. Strong correlations between fabric parameters and channel parameters were obtained for the channel clearance area and approximate channel volume, warp and channel ground area, weft count and fabric thickness, channel inlet diameter, and fabric thickness.
Oncotargets and Therapy Dovepress Prognostic Implications of Kindlin Proteins in Human Osteosarcoma

hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms Abstract: The Kindlin protein family, comprising Kindlin-1, Kindlin-2 and Kindlin-3, play important roles in various human cancers. Here, to explore the clinical significance of Kindlins in human osteosarcomas, quantitative real-time PCR and Western blot analyses were performed to detect the expression of Kindlin-1, Kindlin-2 and Kindlin-3 mRNAs and proteins in 20 self-pairs of osteosarcoma and adjacent noncancerous tissues. Then, immunohistochemistry was performed to examine subcellular localizations and expression patterns of Kindlin proteins in 100 osteosarcoma and matched adjacent noncancerous tissues. Kindlin-1, Kindlin-2 and Kindlin-3 protein immunostainings were localized in the cytoplasm, nucleus and cytoplasm, respectively, of tumor cells in primary osteosarcoma tissues. Statistically, the expression levels of Kindlin-1 and Kindlin-2 mRNAs and proteins in osteosarcoma tissues were all significantly higher (both P,0.01), but those of Kindlin-3 mRNA and protein were both dramatically lower (both P,0.05), than in matched adjacent noncancerous tissues. In addition, the overexpressions of Kindlin-1 and Kindlin-2 proteins were both significantly associated with high tumor grade (both P=0.01), presence of metastasis (both P=0.006), recurrence (both P=0.006) and poor response to chemotherapy (both P=0.02). Moreover, Kindlin-1 and Kindlin-2 expressions were both identified as independent prognostic factors for overall (both P=0.01) and disease-free (P=0.02 and 0.01, respectively) survivals of osteosarcoma patients. However, no associations were observed between Kindlin-3 expression and various clinicopathologic features and patients' prognosis. In conclusion, aberrant expression of Kindlin-1 and Kindlin-2 may function as reliable markers for progression and prognosis in osteosarcoma patients, especially for tumor recurrence.