Miracle-dz/UniFAR-FTUs huggingface dataset:
THE RELATION BETWEEN "WORKAHOLISM" and "OCCUPATIONAL STRESS": A CASE STUDY ABOUT "WELFARE ORGANIZATION PERSONNEL" OF KERMAN, IRAN

“Workaholism” is a psychological dependency which could be satisfying or problematic for the people. This difficulty is called “Karoshi” in Japanese culture that means fatality because of too much working (Oates, 1971). The main objective followed by the present study is to verify the Relation between “Workaholism” and Occupational Stress among Welfare Organization’s Personnel of Kerman. The research method is composed of Data Correlation and Accumulation type through “Workaholism” and “Occupational Stress” questionnaires. The statistical population of the study was randomly selected among the personnel who had BA degrees or higher University Degrees. The volume of the sample has been extracted through “Kokran” relation and reported as 174. The data accumulation tools were two questionnaires in which the “Workaholism” questionnaire contained 28 questions with the validity of 0.93% and Stability of 0.98 % and the “Occupational Stress” questionnaire contained 23 Questions with the validity of 0.95 % and the stability of 0.86 %. Generally, the results of the study show a significant relation between “Workaholism” and “Occupational Stress” among Welfare Organization’s Personnel of Kerman, and also it was found a meaningful relation between “Occupational Stress” and related aspects of “Workaholism” (as; Pleasure of Working, Working Enthusiasm, Molding in Work, Idealism). But, there was seen no considerable relation between the feeling of “Working Enthusiasm” and “Occupational Stress”.
In silico design of context-responsive mammalian promoters with user-defined functionality

Abstract Comprehensive de novo-design of complex mammalian promoters is restricted by unpredictable combinatorial interactions between constituent transcription factor regulatory elements (TFREs). In this study, we show that modular binding sites that do not function cooperatively can be identified by analyzing host cell transcription factor expression profiles, and subsequently testing cognate TFRE activities in varying homotypic and heterotypic promoter architectures. TFREs that displayed position-insensitive, additive function within a specific expression context could be rationally combined together in silico to create promoters with highly predictable activities. As TFRE order and spacing did not affect the performance of these TFRE-combinations, compositions could be specifically arranged to preclude the formation of undesirable sequence features. This facilitated simple in silico-design of promoters with context-required, user-defined functionalities. To demonstrate this, we de novo-created promoters for biopharmaceutical production in CHO cells that exhibited precisely designed activity dynamics and long-term expression-stability, without causing observable retroactive effects on cellular performance. The design process described can be utilized for applications requiring context-responsive, customizable promoter function, particularly where co-expression of synthetic TFs is not suitable. Although the synthetic promoter structure utilized does not closely resemble native mammalian architectures, our findings also provide additional support for a flexible billboard model of promoter regulation.
Investigating the Causes of the Response of the Thermohaline Circulation to Past and Future Climate Changes

The Atlantic thermohaline circulation (THC) is an important part of the earth’s climate system. Previous research has shown large uncertainties in simulating future changes in this critical system. The simulated THC response to idealized freshwater perturbations and the associated climate changes have been intercompared as an activity of World Climate Research Program (WCRP) Coupled Model Intercomparison Project/Paleo-Modeling Intercomparison Project (CMIP/PMIP) committees. This intercomparison among models ranging from the earth system models of intermediate complexity (EMICs) to the fully coupled atmosphere–ocean general circulation models (AOGCMs) seeks to document and improve understanding of the causes of the wide variations in the modeled THC response. The robustness of particular simulation features has been evaluated across the model results. In response to 0.1-S v( 1 Sv 10 6 m 3 s 1 ) freshwater input in the northern North Atlantic, the multimodel ensemble mean THC weakens by 30% after 100 yr. All models simulate some weakening of the THC, but no model simulates a complete shutdown of the THC. The multimodel ensemble indicates that the surface air temperature could present a complex anomaly pattern with cooling south of Greenland and warming over the Barents and Nordic Seas. The Atlantic ITCZ tends to shift southward. In response to 1.0-Sv freshwater input, the THC switches off rapidly in all model simulations. A large cooling occurs over the North Atlantic. The annual mean Atlantic ITCZ moves into the Southern Hemisphere. Models disagree in terms of the reversibility of the THC after its shutdown. In general, the EMICs and AOGCMs obtain similar THC responses and climate changes with more pronounced and sharper patterns in the AOGCMs.
Subunit‐specific desensitization of heteromeric kainate receptors

Kainate receptor subunits can form functional channels as homomers of GluK1, GluK2 or GluK3, or as heteromeric combinations with each other or incorporating GluK4 or GluK5 subunits. However, GluK4 and GluK5 cannot form functional channels by themselves. Incorporation of GluK4 or GluK5 into a heteromeric complex increases glutamate apparent affinity and also enables receptor activation by the agonist AMPA. Utilizing two‐electrode voltage clamp of Xenopus oocytes injected with cRNA encoding kainate receptor subunits, we have observed that heteromeric channels composed of GluK2/GluK4 and GluK2/GluK5 have steady state concentration–response curves that were bell‐shaped in response to either glutamate or AMPA. By contrast, homomeric GluK2 channels exhibited a monophasic steady state concentration–response curve that simply plateaued at high glutamate concentrations. By fitting several specific Markov models to GluK2/GluK4 heteromeric and GluK2 homomeric concentration–response data, we have determined that: (a) two strikingly different agonist binding affinities exist; (b) the high‐affinity binding site leads to channel opening; and (c) the low‐affinity agonist binding site leads to strong desensitization after agonist binding. Model parameters also approximate the onset and recovery kinetics of desensitization observed for macroscopic currents measured from HEK‐293 cells expressing GluK2 and GluK4 subunits. The GluK2(E738D) mutation lowers the steady state apparent affinity for glutamate by 9000‐fold in comparison to GluK2 homomeric wildtype receptors. When this mutant subunit was expressed with GluK4, the rising phase of the glutamate steady state concentration–response curve overlapped with the wildtype curve, whereas the declining phase was right‐shifted toward lower affinity. Taken together, these data are consistent with a scheme whereby high‐affinity agonist binding to a non‐desensitizing GluK4 subunit opens the heteromeric channel, whereas low‐affinity agonist binding to GluK2 desensitizes the whole channel complex.
Comparative MD Simulations Indicate a Dual Role for Arg1323.50 in Dopamine-Dependent D2R Activation

Residue Arg3.50 belongs to the highly conserved DRY-motif of class A GPCRs, which is located at the bottom of TM3. On the one hand, Arg3.50 has been reported to help stabilize the inactive state of GPCRs, but on the other hand has also been shown to be crucial for stabilizing active receptor conformations and mediating receptor-G protein coupling. The combined results of these studies suggest that the exact function of Arg3.50 is likely to be receptor-dependent and must be characterized independently for every GPCR. Consequently, we now present comparative molecular-dynamics simulations that use our recently described inactive-state and Gα-bound active-state homology models of the dopamine D2 receptor (D2R), which are either bound to dopamine or ligand-free, performed to identify the function of Arg1323.50 in D2R. Our results are consistent with a dynamic model of D2R activation in which Arg1323.50 adopts a dual role, both by stabilizing the inactive-state receptor conformation and enhancing dopamine-dependent D2R-G protein coupling.
The person as moralist account and its alternatives

Abstract The commentators offer helpful suggestions at three levels: (1) explanations for the particular effects discussed in the target article; (2) implications of those effects for our understanding of the role of moral judgment in human cognition; and (3) more theoretical questions about the overall relationship between ordinary cognition and systematic science. The present response takes up these three issues in turn.
Prevalence of sleep problems and quality of life in an older population.

STUDY OBJECTIVES To determine the prevalence of insomnia traits in a population and the effect of these traits on health-related quality of life. DESIGN The Epidemiology of Hearing Loss Study is a population-based study in Beaver Dam, Wisconsin. SETTING Participants were interviewed as part of the 5-year follow-up examination (1998-2000) of the Epidemiology of Hearing Loss Study. Participants were interviewed at the study office in Beaver Dam, WI, by telephone, or at their residence. PARTICIPANTS 2800 adults aged 53-97 years. INTERVENTIONS N/A. MEASUREMENTS AND RESULTS Participants were asked to what extent they experienced difficulty getting to sleep, waking up at night and having a hard time getting back to sleep, and waking up repeatedly during the night for any reason. A response of "often" or "almost always" was coded as positive for an insomnia trait. The SF-36 was administered to assess mental and physical function. Twenty-six percent of the population reported one insomnia trait, 13% reported two, and 10% reported three. All eight domains and the Mental and Physical Component Summary scores of the SF-36 decreased significantly (F-test for linear trend statistically significant at p<0.0001) as the number of reported insomnia traits increased. CONCLUSIONS These results indicate that symptoms of insomnia are common among older adults and are associated with a decrease in health related quality of life.
Emotions about crime and attitudes to punishment

Various polls and surveys seem to indicate that a substantial proportion of the Canadian public desires harsher penalties for crime. While various explanations have been offered for this punitiveness, emotional reactions to crime have been under-researched. The present research draws on a Canadian data set to test the hypothesis that the emotions of fear and particularly anger about crime are significant predictors of punitive attitudes once crime victimization, economic insecurity, internal attributions of crime causation and other variables are controlled for. This research also examines the possible indirect effects of economic insecurity, victimization and internal attributions of crime causation on punitiveness through their impact on fear and anger. The multiple regression results support the role of emotions, particularly anger, in explaining punitive attitudes. While indirect effects of victimization and economic insecurity were insignificant, 14 per cent of the effect of internal attributions was through anger.
Designing Business Models for Platform as a Service: Towards a Design Theory

Platform as a Service (PaaS) solutions are changing the way that software is produced, distributed, consumed, and priced. Unlike Software as a Service or Infrastructure as a Service, PaaS allows for value co-creation by offering complementary components and applications that are developed in emerging ecosystems of third-party developers. Despite increasing interest among practitioners and researchers, there has been little work in understanding how PaaS business models should be designed to establish a flourishing ecosystem. We aim at developing a design theory that facilitates the design of PaaS business models, taking into account the specifics of multisided business models. Four meta-requirements describe the purpose and scope of our design theory, and six design principles guide PaaS providers in designing effective business models. By focusing on designing business models, our research goes beyond previous approaches for studying PaaS.
Cultural Identity and Place in Adult Korean-American Intercountry Adoptees

ABSTRACT This study explores the interrelationship between cultural identity and place in the lives of adult Korean adoptees living primarily in the Twin Cities area of Minnesota. Using life histories derived through multiple semi-structured interviews, a web of related themes emerged which reveal the interplay between ethnicity, identity, gender, and place. From childhood to adulthood, most Korean adoptees followed a similar developmental trajectory of denial, self-awareness, and emerging cultural consciousness about their Korean heritage, particularly upon their departure from their adoptive homes after high school. These journeys were mediated and nuanced by environmental factors including -but not limited to -places adoptees lived or visited in Korea, the U.S. or elsewhere abroad. This study highlights the limitations of previous studies that focused only on adoptive parents or adoptees as children, an approach which loses the life course perspective of inter-country adoptees' search for identity, bel.
Challenges and Opportunities in Pediatric Heart Failure and Transplantation Right Versus Left Ventricular Failure Differences, Similarities, and Interactions

1033 Ventricular failure manifests in many forms, its underlying physiology ranging from overt left ventricular (LV) systolic dysfunction to isolated right ventricular (RV) diastolic dysfunction, and the wide portfolio of resulting symptoms vary from chronic fluid retention to acute multiorgan dysfunction and death. In this review, we discuss the morphological, functional, and molecular similarities and differences in RV and LV responses to adverse loading and failure. We further discuss whether LV and RV function and failure can truly be discussed as separate entities and thereby examine interactions between the ventricles that on one hand contribute to ventricular dysfunction but on the other may be harnessed for therapeutic benefit.
Making ‘The Daily Me’: Technology, economics and habit in the mainstream assimilation of personalized news

The mechanisms of personalization deployed by news websites are resulting in an increasing number of editorial decisions being taken by computer algorithms — many of which are under the control of external companies — and by end users. Despite its prevalence, personalization has yet to be addressed fully by the journalism studies literature. This study defines personalization as a distinct form of interactivity and classifies its explicit and implicit forms. Using this taxonomy, it surveys the use of personalization at 11 national news websites in the UK and USA. Research interviews bring a qualitative dimension to the analysis, acknowledging the influence that institutional contexts and journalists’ attitudes have on the adoption of technology. The study shows how: personalization informs debates on news consumption, content diversity, and the economic context for journalism; and how it challenges the continuing relevance of established theories of journalistic gate-keeping.
Use of Drug Effect Interaction Modeling with Monte Carlo Simulation To Examine the Impact of Dosing Interval on the Projected Antiviral Activity of the Combination of Abacavir and Amprenavir

ABSTRACT The delineation of optimal regimens for combinations of agents is a difficult problem, in part because, to address it, one needs to (i) have effect relationships between the pathogen in question and the drugs in the combination, (ii) have knowledge of how the drugs interact (synergy, antagonism, and additivity), and (iii) address the issue of true between-patient variability in pharmacokinetics for the drugs in the population. We have developed an approach which employs a fully parametric assessment of drug interaction using the equation of W. R. Greco, G. Bravo, and J. C. Parsons (Pharmacol. Rev. 47:331–385, 1995) to generate an estimate of effects for the two drugs and have linked this approach to a population simulator, using Monte Carlo methods, which produce concentration-time profiles for the drugs in combination. This software automatically integrates the effect over a steady-state dosing interval and produces an estimate of the mean effect over a steady-state interval for each simulated subject. In this way, doses and schedules can be easily evaluated. This software allows for a rational choice of dose and schedule for evaluation in clinical trials. We evaluated different schedules of administration for the combination of the nucleoside analogue abacavir plus the human immunodeficiency virus type 1 protease inhibitor amprenavir. Amprenavir was simulated as either 800 mg every 8 h (q8h) or 1,200 mg q12h, each along with 300 mg q12h of abacavir. Both regimens produced excellent effects over the simulated population of 500 subjects, with average percentages of maximal effect (as determined from the in vitro assays) of 90.9% ± 11.4% and 80.9% ± 18.6%, respectively. This difference is statistically significant (P≪ 0.001). In addition, 68.8 and 46.0% of the population had an average percentage of maximal effect which was greater than or equal to 90% for the two regimens. We can conclude that the combination of abacavir plus amprenavir is a potent combination when it is given on either schedule. However, the more fractionated schedule for the protease inhibitor produced significantly better effects in combination. Clinicians need to explicitly balance the improvement in antiviral effect seen with the more fractionated regimen against the loss of compliance attendant to the use of such a regimen. This approach may be helpful in the preclinical evaluation of multidrug anti-infective regimens.
Gastric Cancer Originating from Bone Marrow-Derived Cells

Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow–derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.
A Study of Evoked Potentials From Ear-EEG

A method for brain monitoring based on measuring the electroencephalogram (EEG) from electrodes placed in-the-ear (ear-EEG) was recently proposed. The objective of this study is to further characterize the ear-EEG and perform a rigorous comparison against conventional on-scalp EEG. This is achieved for both auditory and visual evoked responses, over steady-state and transient paradigms, and across a population of subjects. The respective steady-state responses are evaluated in terms of signal-to-noise ratio and statistical significance, while the qualitative analysis of the transient responses is performed by considering grand averaged event-related potential (ERP) waveforms. The outcomes of this study demonstrate conclusively that the ear-EEG signals, in terms of the signal-to-noise ratio, are on par with conventional EEG recorded from electrodes placed over the temporal region.
On the Uncoded BER Performance Bound of the IEEE 802.16d Channel

In this letter, the performance bound of the IEEE 802.16d channel is examined analytically in order to gain an insight into its theoretical potential. Different design strategies, such as orthogonal frequency division multiplexing (OFDM) and single-carrier frequency-domain equalization (SC-FDE), time-domain decision feedback equalization (DFE), and sphere decoder (SD) techniques are discussed and compared to the theoretical bound.
A comparative study of reducing the extracellular potassium concentration in red blood cells by washing and by reduction of additive solution

BACKGROUND: Extracellular potassium concentration (K+) increases in the supernatant of whole and packed red blood cell units (pRBCs) with duration of refrigerated storage in citrate‐phosphate‐dextrose‐adenine (CPDA‐1) and additive solution (AS). Studies have shown that to avoid hyperkalemia, washed pRBCs are preferred if relatively fresh pRBCs are not available. To determine whether a simpler procedure, AS reduction, results in lowering of K+ in pRBCs comparable to that achieved by washing, the K+ levels by both methods were compared.
Through a Glass Darkly: Information Technology Design, Identity Verification, and Knowledge Contribution in Online Communities

A variety of information technology (IT) artifacts, such as those supporting reputation management and digital archives of past interactions, are commonly deployed to support online communities. Despite their ubiquity, theoretical and empirical research investigating the impact of such IT-based features on online community communication and interaction is limited. Drawing on the social psychology literature, we describe an identity-based view to understand how the use of IT-based features in online communities is associated with online knowledge contribution. Specifically, the use of four categories of IT artifacts---those supporting virtual co-presence, persistent labeling, self-presentation, and deep profiling---is proposed to enhance perceived identity verification, which thereafter promotes satisfaction and knowledge contribution. To test the theoretical model, we surveyed more than 650 members of two online communities. In addition to the positive effects of community IT artifacts on perceived identity verification, we also find that perceived identity verification is strongly linked to member satisfaction and knowledge contribution. This paper offers a new perspective on the mechanisms through which IT features facilitate computer-mediated knowledge sharing, and it yields important implications for the design of the supporting IT infrastructure.
Resonance‐thrombography indices of the haemostatic process in relation to risk of incident coronary heart disease: 9 years follow‐up in the Caerphilly Prospective Heart Disease Study

Global assays, such as resonance‐thrombography (RTG), which measure the interaction between platelets, coagulation and fibrinolysis have been used as summary measures of risk for over two decades but have not been evaluated in epidemiological studies. We examined whether RTG indices are risk indicators for incident coronary heart disease (CHD). RTG indices, related haematological variables and other risk factors were measured between 1984 and 1988 in a cohort of 2398 British men. Reaction time (r) and amplitude of fibrin leg (AF) were associated with lifestyle risk factors. During 9 years of follow‐up, 282 (12%) men developed a major new CHD event, as classified by World Health Organization criteria. On adjustment for age, only r and AF measured at baseline were related to risk of incident CHD. On multivariate adjustment in a multiple logistic regression model that included age, diastolic blood pressure, body mass index, total and high‐density lipoprotein cholesterol, lifestyle risk factors and use of prescribed medicine, these associations weakened but remained significant. Additional adjustment for fibrinogen, viscosity, white cell count and fibrin d‐dimer either reduced these associations to non‐significance (AF) or to borderline significance (r).