Miracle-dz/UniFAR-FTUs huggingface dataset:
ACE inhibitors captopril and enalapril induce regression of left ventricular hypertrophy in hypertensive patients with chronic renal failure.

BACKGROUND Left ventricular hypertrophy is frequently noted in patients with moderate to severe chronic renal failure not requiring dialysis. Recently, several studies have shown reversal of myocardial hypertrophy in end-stage renal disease with long-term pharmacological control of blood pressure, but it is unclear whether left ventricular mass regresses or normalizes with antihypertensive treatment of patients with earlier stages of chronic renal failure. METHODS Seventy-two undialysed patients with chronic renal failure, chronic mild-to-moderate hypertension, and left ventricular hypertrophy were randomly assigned in a prospective study to either the captopril (n = 36) or enalapril group (n = 36). Blood pressure measurements, echocardiographic and Doppler parameters were evaluated before treatment and at 6 and 12 months of therapy. RESULTS During follow-up, six patients developed side-effects including dry cough, taste disturbances, skin rash and gastric intolerance. In the captopril group there was a decrease in mean left ventricular mass index by 12% after 6 months of treatment, which decreased by 20% after 12 months treatment. For enalapril, the average reduction of myocardial mass after 6 months treatment was 14% and after 12 months treatment, the decrease was 19%. In both treatment groups there was significant improvement of left ventricular filling dynamics. No deterioration of left ventricular systolic function was observed. CONCLUSIONS Our results confirm that antihypertensive monotherapy with the ACE inhibitors, captopril and enalapril, in patients with chronic renal failure results in regression of left ventricular mass index associated with a significant improvement in the diastolic function of the left ventricle without a demonstrable deterioration in left ventricular systolic performance.
Virus infection stages and distinct Th1 or Th17/Th22 T-cell responses in malaria/SHIV coinfection correlate with different outcomes of disease.

BACKGROUND Malaria and AIDS represent 2 leading causes of death from infectious diseases worldwide, and their high geographic overlap means coinfection is prevalent. It remains unknown whether distinct immune responses during coinfection with malaria and human immunodeficiency virus (HIV) affect clinical outcomes. METHODS We tested this hypothesis by employing macaque models of coinfection with malaria and simian-human immunodeficiency virus (SHIV). RESULTS Plasmodium fragile malaria coinfection of acutely SHIV-infected macaques induced hyperimmune activation and remarkable expansion of CD4+ and CD8+ T effector cells de novo producing interferon γ or tumor necrosis factor α. Malaria-driven cellular hyperactivation/expansion and high-level Th1-cytokines enhanced SHIV disease characterized by increasing CD4+ T-cell depletion, profound lymphoid depletion or destruction, and even necrosis in lymph nodes and spleens. Importantly, malaria/SHIV-mediated depletion, destruction, and necrosis in lymphoid tissues led to bursting parasite replication and fatal virus-associated malaria. Surprisingly, chronically SHIV-infected macaques without AIDS employed different defense mechanisms during malaria coinfection, and mounted unique ∼200-fold expansion of interleukin 17+/interleukin 22+ T effectors with profound Th1 suppression. Such remarkable expansion of Th17/Th22 cells and inhibition of Th1 response coincided with development of immunity against fatal virus-associated malaria without accelerating SHIV disease. CONCLUSIONS These novel findings suggest that virus infection status and selected Th1 or Th17/Th22 responses after malaria/AIDS-virus coinfection correlate with distinct outcomes of virus infection and malaria.
Cellulose synthase interactive protein 1 (CSI1) links microtubules and cellulose synthase complexes

Cellulose synthase (CESA) complexes can be observed by live-cell imaging to move with trajectories that parallel the underlying cortical microtubules. Here we report that CESA interactive protein 1 (CSI1) is a microtubule-associated protein that bridges CESA complexes and cortical microtubules. Simultaneous in vivo imaging of CSI1, CESA complexes, and microtubules demonstrates that the association of CESA complexes and cortical microtubules is dependent on CSI1. CSI1 directly binds to microtubules as demonstrated by in vitro microtubule-binding assay.
Six months of maintenance chemotherapy after intensified treatment for acute lymphoblastic leukemia of childhood.

PURPOSE We postulated that intensification of chemotherapy immediately after remission induction might reduce the leukemic cell burden sufficiently to allow an abbreviated period of antimetabolite therapy. PATIENTS AND METHODS Three hundred forty-seven children (ages 1 to 15 years) with previously untreated acute lymphoblastic leukemia (ALL) were enrolled onto the Tokyo L92-13 study, which excluded patients with mature B-cell ALL and patients less than 1 year old. One hundred twenty-four patients were classified as standard risk, 122 as high risk, and 101 as extremely high risk, according to age, peripheral-blood leukocyte count, selected genetic abnormalities, and immunophenotype. All subjects received four drugs for remission induction, followed by a risk-directed multidrug intensification phase and therapy for presymptomatic leukemia in the CNS. Maintenance chemotherapy with oral mercaptopurine and methotrexate was administered for 6 months, with all treatment stopped by 1 year after diagnosis. RESULTS The mean (+/- SD) event-free survival (EFS) and overall survival rates for all patients were 59.5% +/- 3.4% and 81.5% +/- 2.2%, respectively, at 5. 5 years after diagnosis. EFS rates by risk category were similar (60. 2% +/- 6.0% for standard risk, 57.7% +/- 5.6% for high risk, and 62. 5% +/- 5.7% for extremely high risk), whereas overall survival rates differed significantly (91.2% +/- 2.7%, 80.0% +/- 4.1%, and 72.1% +/- 4.5%, respectively, P <.0001 by the log-rank test). There were 107 relapses. Eighty-five (79.4%) of these 107 patients achieved second complete remissions, with subsequent EFS rates of 61.5% +/- 7. 9% (standard risk), 42.6% +/- 8.1% (high risk), and 9.6% +/- 6.4% (extremely high risk). Of the five risk factors analyzed, only the response to prednisolone monotherapy among extremely high-risk patients proved important. CONCLUSION Early treatment intensification did not compensate for a truncated phase of maintenance chemotherapy in children with standard- or high-risk ALL. However, 6 months of antimetabolite treatment seemed adequate for extremely high-risk patients who were good responders to prednisolone and received intensified chemotherapy that included high-dose cytarabine early in the clinical course.
Empirical mode reduction in a model of extratropical low-frequency variability

This paper constructs and analyzes a reduced nonlinear stochastic model of extratropical low-frequency variability. To do so, it applies multilevel quadratic regression to the output of a long simulation of a global baroclinic, quasigeostrophic, three-level (QG3) model with topography; the model’s phase space has a dimension of O(10 4 ). The reduced model has 45 variables and captures well the non-Gaussian features of the QG3 model’s probability density function (PDF). In particular, the reduced model’s PDF shares with the QG3 model its four anomalously persistent flow patterns, which correspond to opposite phases of the Arctic Oscillation and the North Atlantic Oscillation, as well as the Markov chain of transitions between these regimes. In addition, multichannel singular spectrum analysis identifies intraseasonal oscillations with a period of 35–37 days and of 20 days in the data generated by both the QG3 model and its low-dimensional analog. An analytical and numerical study of the reduced model starts with the fixed points and oscillatory eigenmodes of the model’s deterministic part and uses systematically an increasing noise parameter to connect these with the behavior of the full, stochastically forced model version. The results of this study point to the origin of the QG3 model’s multiple regimes and intraseasonal oscillations and identify the connections between the two types of behavior.
Femoral osteochondritis of the knee: prognostic value of the mechanical axis

Purpose Femoral osteochondritis dissecans (OCD) is a disorder of unknown aetiology and variable prognosis that causes knee pain. In this paper, the authors study the impact of lower limb malalignment on the development and prognosis of OCD. Methods After anteroposterior (AP) and lateral radiograph and MRI of the knee, 53 cases of OCD were diagnosed. All patients were studied by standing full-length AP radiograph of the lower extremities in order to analyse the relationship between the femorotibial and mechanical axis and the location and stability of the osteochondritis. Results The OCD lesion was located in the medial condyle (zone 2) in 75.5% of cases (40 cases). The lateral condyle was affected in 24.5% of cases (zone 4 in nine cases and zone 5 in four cases). The femorotibial angle (anatomical axis) was normally aligned in 68% of cases. A valgus deformity was observed in 9.5% of cases and a varus deformity in 22.5%. The mechanical axis of the limb appeared normal in only 32% of cases, with medial deviation in 53%, and lateral deviation in 15% of cases. When the OCD lesion was located in the medial condyle (40 cases), the mechanical axis also crossed the knee through the medial zone in 28 cases. When the OCD lesion was located in the lateral condyle (13 cases), the mechanical axis crossed the knee through zones 1 or 2 in four cases. In stable OCD, the mechanical axis and location of the lesion coincided in 19 of 36 cases (52%), compared with 16 of 17 cases (94%) in unstable OCD. Conclusions There is a high correlation between OCD location and lower limb mechanical axis deviation. The convergence of the mechanical axis with the location of the OCD lesion may be considered an associated factor in fragment instability. This convergence is more common in unstable OCD.
Message Forwarding in Sparsely Connected Wireless Networks Using Rateless Codes

Rateless codes can reduce retransmission costs over erasure channels. Existing routing algorithms using rateless codes assume densely connected networks and predecide the forwarder nodes, which subsequently participate in message forwarding. Using a rateless code, which is easy to analyze and implement, we propose practically implementable opportunistic message forwarding algorithms for sparsely connected networks, in which all the nodes can potentially participate in forwarding, and study their performance through simulations.
Systematically Evaluating Security and Privacy for Consumer IoT Devices

Internet-of-Things (IoT) devices such as smart bulbs, cameras, and health monitors are being enthusiastically adopted by consumers, with numbers projected to rise to the billions. However, such devices are also easily attacked, or used for launching attacks, at large scale and at increasing frequency. This paper is an attempt at developing a systematic method to identify the security and privacy shortcomings of various IoT devices, with a view towards alerting consumers, manufacturers, and regulators to the associated risks. We categorize the threats along four dimensions: confidentiality of private data sent to/from the IoT device; integrity of data from the IoT device to internal/external entities; access control of the IoT device; and reflective attacks that can be launched from an IoT device. We develop scripts to automate the security testing along each of these dimensions, subject twenty market-ready consumer IoT devices to our test suite, and reveal findings that give a fairly comprehensive picture of the security/privacy posture of these devices. Our methodology can be used as a basis for a star-based security ratings system for IoT devices being brought to market.
Comparison of Renal Transplantation Outcomes in Patients After Peritoneal Dialysis and Hemodialysis – A Case Control Study and Literature Review

A very interesting point became obvious when analyzing data obtained from the Dialysis Morbidity and Mortality Study Wave 2, a national random sample of more than 4000 new dialysis patients in the USA enrolled during 1996 and 1997 and followed up until 2001. There, it was shown, that transplantation rates were significantly higher for patients reporting the greatest contribution to modality selection. These results support the association of patient
Comparison of cardiovascular response to laryngoscopy and tracheal intubation after induction of anesthesia by Propofol and Etomidate

Background: Etomidate and Propofol are common anesthetic agents. Previous studies say that Etomidate can be used in patients with limited hemodynamic reserve and Propofol can lead to more hemodynamic instabilities. This study was performed to explore the cardiovascular response during the induction of anesthesia with Etomidate or for comparison, Propofol in elective orthopedic surgeries. Materials and Methods: This study was a double-blinded randomized clinical trial study including patients 18-45 years of age that were admitted for elective orthopedic surgeries in 2012. 25consenting, ASA I (American Society of Anaesthesiologists), patients were evaluated randomly in two groups, and their cardiovascular responses including: systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and O2 saturation (O2 sat) were measured before the laryngoscopy, during the anesthesia induction with Etomidate (0.3 mg/kg) in group A and propfol (2-2.5 mg/kg) in group B and at 1, 3, 5,10 min after the induction. Results: There were no statistical differences between both groups regarding gender, age, body mass index, and laryngoscopic grade of patients (P > 0.05). Changes of SBP in the group B was significantly higher (P = 0.019). Furthermore, changes of the DBP was significantly higher in the group B (P = 0.001). The changes of MAP was higher in group B (P = 0.008). Hypotension happened in 26.1% of group B and 8% of group A (P = 0.09). There were no significant differences among groups A and B in terms of HR (P = 0.47) and O2 sat (P = 0.21), tachycardia (P = 0.6), bradycardia (P = 0.66) and hypertension (P = 0.95). Conclusion: Since, patients receiving Etomidate have more stable hemodynamic condition, if there would be no contraindications, it could be preferred over Propofol for general anesthesia.
Instance-driven TBox Revision in DL-Lite

The development and maintenance of large and complex ontologies are often time-consuming and error-prone. Thus, automated ontology learning and revision have attracted intensive research interest. In data-centric applications where ontologies are designed or automatically learnt from the data, when new data instances are added that contradict to the ontology, it is often desirable to incrementally revise the ontology according to the added data. This problem can be intuitively formulated as the problem of revising a TBox by an ABox. In this paper we introduce a model-theoretic approach to such an ontology revision problem by using a novel alternative semantic characterisation of DL-Lite ontologies. We show some desired properties for our ontology revision. We have also developed an algorithm for reasoning with the ontology revision without computing the revision result. The algorithm is efficient as its computational complexity is in coNP in the worst case and in PTIME when the size of the new data is bounded.
Rightcania and Kvacekispermum: Early Cretaceous Seeds From Eastern North America and Portugal Provide Further Evidence of the Early Chloranthoid Diversification

Abstract Abundant flowers, fruits, seeds and stamens that are closely related to extant Chloranthaceae have been reported from the Early Cretaceous floras of Portugal. Among these are small berries with endotestal seeds assigned to the extinct genera Canrightia and Canrightiopsis. Here we describe two new genera, each including a single species, based on fossil fruits and seeds from the Early Cretaceous of eastern North America and Portugal. Both genera have pendent, orthotropous, bitegmic and endotestal ovules/seeds, in which the endotesta consists of a layer of cubic to palisade-shaped crystal cells with endoreticulate fibrous infillings, a combination of features that also characterize Canrightia and Canrightiopsis and that among extant angiosperms are known only for members of the Chloranthaceae. Rightcania kvacekii gen. et sp. nov. from the early to middle Albian Puddledock mesofossil flora of Virginia, USA, is the first representative in the Early Cretaceous floras of North America of a chloranthaceous fossil related to Canrightia and Canrightiopsis. It has three- to five-seeded fruits very similar to fruits and seeds of Canrightia, also with a pronounced tegmen that probably functioned as a nutritive tissue for the developing embryo. Fruits and seeds of Rightcania are larger than those of Canrightia, and also differ in details of the seed coat. Kvacekispermum rugosum gen. et sp. nov. is rare in the late Aptian to early Albian Portuguese mesofossil flora from Vale de Água. It differs from Canrightiopsis in the coarsely rugulate outer surface of the endotesta and its larger size, but is closely similar in the general structure of seed coat and nutritive tissue. Together, Rightcania and Kvacekispermum provide further evidence of the early diversity achieved by chloranthoid angiosperms before the end of the Early Cretaceous.
The use of elicited imitation as a measure of expressive grammar: a question of validity.

Elicited imitation has been suggested as an alternative to Developmental Sentence Scoring (DSS) as a means of measuring grammatical performance. Numerous investigators, however, have demonstrated that short-term memory is a confounding variable during elicited imitation. In the first experiment the imitative skills of 4 year old were assessed as a function of sentence comprehension and delayed imitation. The second experiment examined the relationship between the Carrow Elicited Language Inventory (CELI) and DSS under three imitative conditions; 0, 3, and 5 second delays. Results indicated that subjects were able to accurately repeat sentences which they did not understand as long as imitation was immediate. Delaying imitation 3 seconds adversely affected imitation of noncomprehended sentences while having no significant effect on comprehended sentences. A 3 second delay on the CELI also improved its correlation with DSS from -. 77 (standard procedures) to -. 90. The validity of elicited imitation as a test of expressive grammar is challenged.
Cell Wall Assembly and Intracellular Trafficking in Plant Cells Are Directly Affected by Changes in the Magnitude of Gravitational Acceleration

Plants are able to sense the magnitude and direction of gravity. This capacity is thought to reside in selected cell types within the plant body that are equipped with specialized organelles called statoliths. However, most plant cells do not possess statoliths, yet they respond to changes in gravitational acceleration. To understand the effect of gravity on the metabolism and cellular functioning of non-specialized plant cells, we investigated a rapidly growing plant cell devoid of known statoliths and without gravitropic behavior, the pollen tube. The effects of hyper-gravity and omnidirectional exposure to gravity on intracellular trafficking and on cell wall assembly were assessed in Camellia pollen tubes, a model system with highly reproducible growth behavior in vitro. Using an epi-fluorescence microscope mounted on the Large Diameter Centrifuge at the European Space Agency, we were able to demonstrate that vesicular trafficking is reduced under hyper-gravity conditions. Immuno-cytochemistry confirmed that both in hyper and omnidirectional gravity conditions, the characteristic spatial profiles of cellulose and callose distribution in the pollen tube wall were altered, in accordance with a dose-dependent effect on pollen tube diameter. Our findings suggest that in response to gravity induced stress, the pollen tube responds by modifying cell wall assembly to compensate for the altered mechanical load. The effect was reversible within few minutes demonstrating that the pollen tube is able to quickly adapt to changing stress conditions.
High Signal Intensity on T2‐ Weighted MRI Correlates with Hypoperfusion in Temporal Lobe Epilepsy

Summary: Single‐photon emission computed tomography (SPECT) and [99mTc]HMPAO were used to assess the functional significance of nonspecific magnetic resonance imaging (MRI) abnormalities observed in patients with temporal lobe epilepsy and no focal lesion on CT scan. We studied 18 patients whose MRI was normal or showed high signal intensity on T2‐weighted images (T2WIs) at the site of the EEG focus in 11 and 7 cases, respectively. EEG was monitored during regional cerebral blood flow (rCBF) study. Lateralized hypoperfusion was present in 7 of 17 interictal(41%) and in one Postictal cases; it was located in the temporal lobe on the side of the EEG focus in all, and was significantly more frequent in patients with high signal intensity on T2WI (86%) than in patients with a normal MRI (18%). The degree of temporal perfusion asymmetry measured in each individual was higher in patients whose MRI was abnormal.
Taxonomy and historical inertia: Clidastes (Squamata: Mosasauridae) as a case study of problematic paleobiological taxonomy

I review the taxonomic history of two problematic mosasaur species, Clidastes liodontus and Clidastes moorevillensis. The genus Clidastes is thought to represent an early radiation of a diverse clade known as the Mosasaurinae. However, most phylogenetic analyses recover the genus as paraphyletic with respect to more highly nested mosasaurines such as Mosasaurus, Prognathodon, and Globidens. The fragmentary holotype of Clidastes liodontus was never figured or fully described, and was destroyed in World War II. Over 20 years after destruction of the holotype, relatively complete specimens were referred to Clidastes liodontus based upon a single, variable character. Another taxon, originally designated Clidastes liodontus moorevillensis in a master’s thesis and then elevated to Clidastes moorevillensis in a separate dissertation, has never been formally described and lacks definitive diagnostic characters that differentiate it from the contemporary concept of Clidastes liodontus. Clidastes provides an excellent example of how historical inertia in taxonomic nomenclature can build over decades and skew our interpretations of the diversity, paleobiology, biogeography, and biostratigraphy of a taxon. Clidastes liodontus is a nomen dubium and Clidastes moorevillensis a nomen nudum. I recommend that both names be abandoned. Removal of those names frees us from a burdensome taxonomy and eliminates cognitive biases that hinder objective understanding and exploration of early-diverging mosasaurines, and is a necessary first step toward a taxonomic revision of the lineage(s) involved.