Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiovascular Mortality in Overweight Subjects: The Key Role of Associated Risk Factors

The role of obesity and overweight as independent risk factors for cardiovascular disease is still debated. The aim of this study was to evaluate the impact of overweight on cardiovascular mortality according to the presence or absence of associated risk factors. This study included 139 562 men and 104 236 women, aged 18 to 95 years, who had a standard health checkup at the IPC Center between 1972 and 1988. The follow-up period for mortality ended in December 1997. In both genders, the prevalence of hypertension, diabetes, and hypercholesterolemia increased with body mass index (P<0.001). When compared with subjects with a body mass index <25 kg/m2 without associated risk factors, overweight subjects without associated risk factors did not have an increased risk of cardiovascular mortality. Risk of cardiovascular death increased significantly when overweight was associated with hypertension alone [hazard ratio: 2.05 (1.71 to 2.46) in men; 2.15 (1.48 to 3.11) in women]. In both genders, the association of overweight with diabetes alone or hypercholesterolemia alone did not increase the risk. By contrast, in the presence of hypertension, cardiovascular mortality dramatically increased in overweight subjects with hypercholesterolemia [hazard ratio: 2.65 (2.20 to 3.19) in men, 2.57 (1.80 to 3.68) in women] or diabetes [hazard ratio: 3.01 (2.29 to 3.95) in men; 4.50 (2.67 to 7.58) in women]. The data suggest that the presence of high blood pressure in overweight subjects is the key factor leading to a significant increase in cardiovascular mortality. Because overweight significantly increases the prevalence of associated risk factors, especially hypertension, it should be considered as a major cardiovascular risk determinant.
Classifying EEG for Brain-Computer Interface: Learning Optimal Filters for Dynamical System Features

Classification of multichannel EEG recordings during motor imagination has been exploited successfully for brain-computer interfaces (BCI). In this paper, we consider EEG signals as the outputs of a networked dynamical system (the cortex), and exploit novel features from the collective dynamics of the system for classification. Herein, we also propose a new framework for learning optimal filters automatically from the data, by employing a Fisher ratio criterion. Experimental evaluations comparing the proposed dynamical system features with the CSP and the AR features reveal their competitive performance during classification. Results also show the benefits of employing the spatial and the temporal filters optimized using the proposed learning approach.
Uma proposta de incorporação dos estudos sobre inovação nas pesquisas em jornalismo

The term ‘innovation’ is commonly used in the productive sector because it indicates a movement of knowledge generation linked to the production. In the same way, agencies of research promotion support projects that connect science with the development of knowledge applied to the productive environment. Although the idea of innovation brings in its core an identity with the investigation, the discovery and the know growth that is found in the academy, journalism studies barely incorporate this applied perspective of the scientific knowledge shaped in a terminology and conception that is appropriate to the advance of the studies about the journalistic activity. This article aims to investigate the reasons for this estrangement, although the journalism is a social activity that could directly benefit from the application of the scientific knowledge. We will also pursue to develop the term ‘innovation’ by going beyond its fragile conceptual formulation that has characterized its use. We will indicate that, in journalism, a more complex dimension of the idea of innovation demands the consideration of three aspects – technological, organizational and social innovation. That way we will make it possible to achieve a greater conceptual denseness in order to surpass an excessively technological bias in its approaches.
Tupac Shakur: Understanding the Identity Formation of Hyper-Masculinity of a Popular Hip-Hop Artist

widely criticized by the public as well in numerous political (liberal and conservative) and religious arenas (Fried, 1999). Many critics declare that this type of music is not only extremely vulgar, but that it also perpetuates physical and sexual violence, and promotes sexism. One gangsta rapper in particular, the late Tupac Shakur (19711996), is said to encapsulate all of the above. In the mid-1990s he was one of the most
Nonreplicating Influenza A Virus Vaccines Confer Broad Protection against Lethal Challenge

ABSTRACT New vaccine technologies are being investigated for their ability to elicit broadly cross-protective immunity against a range of influenza viruses. We compared the efficacies of two intranasally delivered nonreplicating influenza virus vaccines (H1 and H5 S-FLU) that are based on the suppression of the hemagglutinin signal sequence, with the corresponding H1N1 and H5N1 cold-adapted (ca) live attenuated influenza virus vaccines in mice and ferrets. Administration of two doses of H1 or H5 S-FLU vaccines protected mice and ferrets from lethal challenge with homologous, heterologous, and heterosubtypic influenza viruses, and two doses of S-FLU and ca vaccines yielded comparable effects. Importantly, when ferrets immunized with one dose of H1 S-FLU or ca vaccine were challenged with the homologous H1N1 virus, the challenge virus failed to transmit to naive ferrets by the airborne route. S-FLU technology can be rapidly applied to any emerging influenza virus, and the promising preclinical data support further evaluation in humans. IMPORTANCE Influenza viruses continue to represent a global public health threat, and cross-protective vaccines are needed to prevent seasonal and pandemic influenza. Currently licensed influenza vaccines are based on immunity to the hemagglutinin protein that is highly variable. However, T cell responses directed against highly conserved viral proteins contribute to clearance of the virus and confer broadly cross-reactive and protective immune responses against a range of influenza viruses. In this study, two nonreplicating pseudotyped influenza virus vaccines were compared with their corresponding live attenuated influenza virus vaccines, and both elicited robust protection against homologous and heterosubtypic challenge in mice and ferrets, making them promising candidates for further evaluation in humans. Influenza viruses continue to represent a global public health threat, and cross-protective vaccines are needed to prevent seasonal and pandemic influenza. Currently licensed influenza vaccines are based on immunity to the hemagglutinin protein that is highly variable. However, T cell responses directed against highly conserved viral proteins contribute to clearance of the virus and confer broadly cross-reactive and protective immune responses against a range of influenza viruses. In this study, two nonreplicating pseudotyped influenza virus vaccines were compared with their corresponding live attenuated influenza virus vaccines, and both elicited robust protection against homologous and heterosubtypic challenge in mice and ferrets, making them promising candidates for further evaluation in humans.
Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal‐1 locus

Disruption of the murine Mop3 (also known as Bmal1 or Arntl) locus results in a loss of behavioral and molecular circadian rhythms. Although Mop3 null mice do not display anomalies in early development, they do display reduced activity as they age. In an effort to explain this decreased activity, we characterized the physiological and anatomical changes that occurred with age. We observed that Mop3 null mice display an increased mortality after 26 weeks of age and a phenotype best described as a progressive noninflammatory arthropathy. Although little pathology is observed prior to 11 weeks of age, by 35 weeks of age essentially all Mop3 null animals develop joint ankylosis due to flowing ossification of ligaments and tendons and almost complete immobilization of weight‐bearing and nonweight‐bearing joints. This pathology appears to explain the decreased activity of Mop3 null mice and suggests that MOP3 is an inhibitor of ligament and tendon ossification. genesis 41:122–132, 2005. © 2005 Wiley‐Liss, Inc.
Model-checking continuous-time Markov chains

We present a logical formalism for expressing properties of continuous-time Markov chains. The semantics for such properties arise as a natural extension of previous work on discrete-time Markov chains to continuous time. The major result is that the verification problem is decidable; this is shown using results in algebraic and transcendental number theory.
Optimal control of wastewater treatment plants using economic-oriented model predictive dynamic strategies

This paper addresses the implementation of economic-oriented model predictive controllers for the dynamic real-time optimization of the operation of wastewater treatment plants (WWTP). Both the economic-optimizing controller (pure-EMPC) and the economic-oriented tracking controller (Hybrid-EMPC, or HEMPC) formulations are validated in the benchmark simulation model (BSM1) platform that represents the behavior of a characteristic activated sludge process. The objective of the controllers is to ensure the appropriate operation of the plant, while minimizing the energy consumption and the fines for violations of the limits of the ammonia concentration in the effluent along the full operating period. A non-linear reduced model of the activated sludge process is used for predictions to obtain a reasonable computing effort, and techniques to deal with model-plant mismatch are incorporated in the controller algorithm. Different designs and structures are compared in terms of process performance and energy costs, which show that the implementation of the proposed control technique can produce significant economic and environmental benefits, depending on the desired performance criteria.
A SEARCH FOR HYDROXYLAMINE (NH2OH) TOWARD SELECT ASTRONOMICAL SOURCES

Observations of 14 rotational transitions of hydroxylamine (NH2OH) using the NRAO 12 m telescope on Kitt Peak are reported toward IRC+10216, Orion KL, Orion S, Sgr B2(N), Sgr B2(OH), W3IRS5, and W51M. Although recent models suggest the presence of NH2OH in high abundance, these observations resulted in non-detection. Upper limits are calculated to be as much as six orders of magnitude lower than those predicted by models. Possible explanations for the lower-than-expected abundance are explored.
DISORDERED SALIVARY IMMUNOGLOBULIN SECRETION AND SODIUM TRANSPORT IN HUMAN CHRONIC GRAFT‐VERSUS-HOST DISEASE

Whole saliva samples and lip biopsies were collected from 12 allogeneic bone marrow transplant recipients who developed extensive chronic graft-versus-host disease (GVHD) and from 10 healthy allogeneic and syngeneic recipients without GVHD. Six of ten biopsies from patients with chronic GVHD had lichenoid stomatitis or sialadenitis, or both, with sialodochitis. Seven of nine biopsies from patients free of chronic GVHD were entirely normal, and two had either mild glandular or mucosal changes. Salivary gland involvement in chronic GVHD was associated with decreased or absent levels of salivary IgA and inorganic phosphate, decreased salivary flow rates, and increased concentrations of salivary sodium, albumin, and IgG. The most striking abnormalities were found in patients with histologic evidence of sialadenitis. In contrast, marrow transplant recipients without chronic GVHD had normal salivary immunoglobulin and electrolyte levels. Secretory IgA deficiency may contribute to the frequent sinobronchial infections observed in patients with chronic GVHD.
Endoscopic ultrasonography versus endoscopic retrograde cholangiopancreatography in acute biliary pancreatitis: a systematic review

Background Acute biliary pancreatitis (ABP) is a clinical condition that can rapidly evolve into a life-threatening one. Endoscopic retrograde cholangiopancreatography (ERCP) has been considered the standard treatment of ABP for many years, though it entails the risk of morbidity and mortality. Endoscopic ultrasonography (EUS) can reliably diagnose choledocholithiasis avoiding unnecessary ERCP in patients with no stones in the biliary tract. Aim We undertook a systematic review of the randomized controlled trials and clinical trials comparing EUS and ERCP to evaluate procedure performance, complication rates, clinical course of pancreatitis, and hospital stay according to the treatment given. Methods A computerized bibliographic search was performed from 1994 to April 2010. Two reviewers assessed the methodological quality of eligible trials and independently extracted data from the included trials. Results Seven studies enrolled 545 patients with acute pancreatitis of suspected biliary origin. Only one was a randomized controlled trial. EUS had a lower failure rate than ERCP in all the studies included, avoiding ERCP in 71.2% of cases. No complications were related to EUS, whereas sphincterotomy was associated with bleeding in up to 22% of patients. The procedures did not influence the clinical course of pancreatitis. Conclusion A strategy based on EUS before ERCP in patients with ABP may be an effective alternative to diagnostic ERCP.
HYPOTrace: Image Analysis Software for Measuring Hypocotyl Growth and Shape Demonstrated on Arabidopsis Seedlings Undergoing Photomorphogenesis1[OA]

Analysis of time series of images can quantify plant growth and development, including the effects of genetic mutations (phenotypes) that give information about gene function. Here is demonstrated a software application named HYPOTrace that automatically extracts growth and shape information from electronic gray-scale images of Arabidopsis (Arabidopsis thaliana) seedlings. Key to the method is the iterative application of adaptive local principal components analysis to extract a set of ordered midline points (medial axis) from images of the seedling hypocotyl. Pixel intensity is weighted to avoid the medial axis being diverted by the cotyledons in areas where the two come in contact. An intensity feature useful for terminating the midline at the hypocotyl apex was isolated in each image by subtracting the baseline with a robust local regression algorithm. Applying the algorithm to time series of images of Arabidopsis seedlings responding to light resulted in automatic quantification of hypocotyl growth rate, apical hook opening, and phototropic bending with high spatiotemporal resolution. These functions are demonstrated here on wild-type, cryptochrome1, and phototropin1 seedlings for the purpose of showing that HYPOTrace generated expected results and to show how much richer the machine-vision description is compared to methods more typical in plant biology. HYPOTrace is expected to benefit seedling development research, particularly in the photomorphogenesis field, by replacing many tedious, error-prone manual measurements with a precise, largely automated computational tool.
Enabling energy efficient reliability in embedded systems through smart cache cleaning

Incessant and rapid technology scaling has brought us to a point where today's, and future transistors are susceptible to transient errors induced by energy carrying particles, called soft errors. Within a processor, the sheer size and nature of data in the caches render it most vulnerable to electrical interference on data stored in the cache. Data in the cache is vulnerable to corruption by soft errors, for the time it remains actively unused in the cache. Write-through and early-write-back [Li et al. 2004] cache configurations reduce the time for vulnerable data in the cache, at the cost of increased memory writes and thereby energy. We propose a smart cache cleaning methodology, that enables copying of only specific vulnerable cache blocks into the memory at chosen times, thereby ensuring data cache protection with minimal memory writes. In this work, we first propose a hybrid (software-hardware) methodology. We then propose an improved software solution that utilizes cache write-back functionality available in commodity processors; thereby reducing the hardware overhead required to implement smart cache cleaning for such systems. The parameters involved in the implementation of our Smart Cache Cleaning (SCC) technique enable a means to provide for customizable energy-efficient soft error reduction in the L1 data cache. Given the system requirements of reliability, power-budget and runtime priority of the application, appropriate parameters of the SCC can be customized to trade-off power consumption and L1 data cache reliability. Our experiments over LINPACK and Livermore benchmarks demonstrate 26% reduced energy-vulnerability product (energy-efficient vulnerability reduction) compared to that of hardware based cache reliability techniques. Our software-only solution achieves same levels of reliability with an additional 28% performance improvement.
Auditory Frequency and Intensity Discrimination Explained Using a Cortical Population Rate Code

The nature of the neural codes for pitch and loudness, two basic auditory attributes, has been a key question in neuroscience for over century. A currently widespread view is that sound intensity (subjectively, loudness) is encoded in spike rates, whereas sound frequency (subjectively, pitch) is encoded in precise spike timing. Here, using information-theoretic analyses, we show that the spike rates of a population of virtual neural units with frequency-tuning and spike-count correlation characteristics similar to those measured in the primary auditory cortex of primates, contain sufficient statistical information to account for the smallest frequency-discrimination thresholds measured in human listeners. The same population, and the same spike-rate code, can also account for the intensity-discrimination thresholds of humans. These results demonstrate the viability of a unified rate-based cortical population code for both sound frequency (pitch) and sound intensity (loudness), and thus suggest a resolution to a long-standing puzzle in auditory neuroscience.
RNA folding with soft constraints: reconciliation of probing data and thermodynamic secondary structure prediction

Thermodynamic folding algorithms and structure probing experiments are commonly used to determine the secondary structure of RNAs. Here we propose a formal framework to reconcile information from both prediction algorithms and probing experiments. The thermodynamic energy parameters are adjusted using ‘pseudo-energies’ to minimize the discrepancy between prediction and experiment. Our framework differs from related approaches that used pseudo-energies in several key aspects. (i) The energy model is only changed when necessary and no adjustments are made if prediction and experiment are consistent. (ii) Pseudo-energies remain biophysically interpretable and hold positional information where experiment and model disagree. (iii) The whole thermodynamic ensemble of structures is considered thus allowing to reconstruct mixtures of suboptimal structures from seemingly contradicting data. (iv) The noise of the energy model and the experimental data is explicitly modeled leading to an intuitive weighting factor through which the problem can be seen as folding with ‘soft’ constraints of different strength. We present an efficient algorithm to iteratively calculate pseudo-energies within this framework and demonstrate how this approach can be used in combination with SHAPE chemical probing data to improve secondary structure prediction. We further demonstrate that the pseudo-energies correlate with biophysical effects that are known to affect RNA folding such as chemical nucleotide modifications and protein binding.
Altered Processing of Acoustic Stimuli during Sleep: Reduced Auditory Activation and Visual Deactivation Detected by a Combined fMRI/EEG Study

Although there is evidence that acoustic stimuli are processed differently during sleep and wakefulness, little is known about the underlying neuronal mechanisms. In the present study, the processing of an acoustic stimulus was investigated during different non rapid eye movement (NREM) sleep stages using a combined EEG/fMRI approach in healthy human volunteers: A text stimulus was presented to sleep-deprived subjects prior to and after the onset of sleep, and single-slice silent fMRI were acquired. We found significantly different blood oxygenation level-dependent (BOLD) contrast responses during sleep compared to wakefulness. During NREM sleep stages 1 and 2 and during slow wave sleep (SWS) we observed reduced activation in the auditory cortex and a pronounced negative signal in the visual cortex and precuneus. Acoustic stimulation during sleep was accompanied by an increase in EEG frequency components in the low delta frequency range. Provided that neurovascular coupling is not altered during sleep, the negative transmodal BOLD response which is most pronounced during NREM sleep stages 1 and 2 reflects a deactivation predominantly in the visual cortex suggesting that this decrease in neuronal activity protects the brain from the arousing effects of external stimulation during sleep not only in the primary targeted sensory cortex but also in other brain regions.
Study of Erythrocyte Aggregation by Blood Viscometry at Low Shear Rates Using a Balance Method

Abalance method was used to investigate the viscometric behavior and aggregation properties of blood at very low shear rates. The system was essentially a parallel-plate viscometer, consisting of a thin brass plate suspended by a fine wire from one end of an analytical beam balance. The yield shear stress of a sample was obtained directly by recording stress relaxation curves. Results were obtained for homogeneous Newtonian and non-Newtonian fluids and for blood and various red cell suspensions. It was found that human and canine blood behave as fluids exhibiting a yield stress. Suspensions of red cells in saline had much smaller values of yield stress, which is consistent with greatly diminished erythrocyte aggregation when fibrinogen is lacking. Measured values of the yield stress were in the range of 0.001 to 0.1 dynes/cm2.
Deletion of the MGMT gene in familial melanoma

The DNA repair gene MGMT (O‐6‐methylguanine‐DNA methyltransferase) is important for maintaining normal cell physiology and genomic stability. Alterations in MGMT play a critical role in the development of several types of cancer, including glioblastoma, lung cancer, and colorectal cancer. The purpose of this study was to explore the function of genetic alterations in MGMT and their connection with familial melanoma (FM). Using multiplex ligation‐dependent probe amplification, we identified a deletion that included the MGMT gene in one of 64 families with a melanoma predisposition living in western Sweden. The mutation segregated with the disease as a heterozygous deletion in blood‐derived DNA, but a homozygous deletion including the promoter region and exon 1 was seen in tumor tissue based on Affymetrix 500K and 6.0 arrays. By sequence analysis of the MGMT gene in the other 63 families with FM from western Sweden, we identified four common polymorphisms, nonfunctional, as predominantly described in previous studies. We conclude that inherited alterations in the MGMT gene might be a rare cause of FM, and we suggest that MGMT contributes to melanoma predisposition. © 2014 Wiley Periodicals, Inc.