Miracle-dz/UniFAR-FTUs huggingface dataset:
YIELD AND ECONOMIC DYNAMICS OF INTERCOPPING IN SUMMER VEGETABLES

Research project entitled “Yield and economic dynamics of intercropping in summer vegetables ” was con ducted at Horticultural Research Farm, NWFP Agricultural University, Peshawar (Pakistan) during 1999 and 2000. Summer vegetables were evaluated alone and in various combinations for their yield, land equivalent ratio and income in intercrop combi nations. Each plot was 4x4 m 2 whereas number of rows varied depending on kind of vegetables. Tomato was intercropped with okra, pot ato, corn, chili and eggplant. Vegetables showed more yield when grown as a single crop than their respective yields in int ercropping except tomato grown in okra and corn. The maximum LER of 2.41 from intercropping of tomato with okra indicates that these two summer vegetables are the best companions and resulted in maximum income of Rs. 196393 ha -1 due to maximum yield of tomato (27.61 t ha -1 ) compared to that of as a sole crop (20.34 t ha -1 ) and high market price of both vegetables. Tomato + corn combination, resulted second highest income of Rs 180700 due to high yields of tomato in intercropping and stabilit y of corn yield in both years. The maximum income was also due to market price of tomato and corn. The least income (Rs.1155 06 ha -1 ) has been recorded from intercropping tomato with potato due to high reduction in yield of both vegetables and h igh cost of production.
Euglycemic Infusion of Insulin Detemir Compared With Human Insulin Appears to Increase Direct Current Brain Potential Response and Reduces Food Intake While Inducing Similar Systemic Effects

OBJECTIVE In the treatment of diabetic patients, the long-acting insulin analog insulin detemir is less prone to induce weight gain than other insulin formulations. Assuming that because of its pharmacologic properties, detemir displays stronger central nervous anorexigenic efficacy than human insulin, we compared acute effects of human insulin and detemir on electroencephalography (EEG) measures and food intake. RESEARCH DESIGN AND METHODS Frontocortical EEG direct current (DC) potentials were recorded in 15 healthy men during two hyperinsulinemic-euglycemic clamps that included an insulin bolus injection (human insulin, 17.75 mU/kg body wt; detemir, 90 mU/kg body wt) followed by a steady 90-min infusion (1.0 vs. 2.0 mU · kg−1 · min−1). A higher dosage was chosen for detemir to compensate for its delay in impact relative to human insulin and to elicit similar systemic effects. At 20 min after infusion, subjects were allowed to eat ad libitum from a test buffet. RESULTS Mean glucose infusions to maintain euglycemia (P > 0.93) and blood glucose concentrations (P > 0.34) did not differ between conditions. Detemir infusion induced a negative DC-potential shift, averaging −372.2 μV from 21 to 90 min that was not observed during human insulin infusion (146.5 μV, P = 0.02). Detemir, in comparison with human insulin, reduced subsequent food intake by 303 kcal (1,257 vs. 1,560, P < 0.04). CONCLUSIONS While inducing comparable peripheral effects, detemir exerts stronger acute effects on brain functions than human insulin and triggers a relative decrease in food consumption, suggesting an enhanced anorexigenic impact of detemir compared with human insulin on central nervous networks that control nutrient uptake.
Comparison between replacement at 4 days and 7 days of the infection rate for pulmonary artery catheters in an intensive care unit*

ObjectiveTo compare the relationship between the time of pulmonary artery catheter replacement (4 days or 7 days after insertion) and the occurrence of catheter-associated infections. DesignOne-year prospective, randomized, controlled clinical trial. SettingSurgical and medical intensive care units at a 2,700-bed medical center. PatientsA total of 258 patients in critical condition who underwent pulmonary artery catheter insertion were recruited. InterventionsAll patients were randomized into two groups (4 days or 7 days) according to the length of time before the pulmonary artery catheter and pressure monitoring system were replaced. Measurements and Main ResultsOver a 12-month period, 331 catheters were inserted in 258 patients. In the per-protocol analysis, 98 patients (73.7%) in the 4-day group and 85 patients (68%) in the 7-day group were enrolled. Twelve patients (14.1%) in the 7-day group and 5 patients (5.1%) in the 4-day group (odds ratio, 3.06; 95% confidence interval, 0.94–10.48) had pulmonary artery catheter-tip colonization. Nine patients (10.5%) in the 7-day group and 7 patients (7.1%) in the 4-day group (odds ratio, 1.54; 95% confidence interval, 0.50–4.85) had bacteremia. In the 7-day group, pulmonary artery catheter-related bacteremia was found in only one patient (1.1%, 1.1 episodes per 1,000 catheter-days) compared with no patients in the 4-day group. The frequency of positive cultures from different sources between the 4-day and 7-day groups was not significantly different in the intention-to-treat analysis (p > .05). ConclusionsNo statistically significant difference was found for pulmonary artery catheter-associated infection when intervals of 4 or 7 days between insertion and replacement were compared. Patients with prolonged pulmonary artery catheterization must be carefully examined for signs or symptoms of infection. The time until pulmonary artery catheter replacement can be extended to 7 days if there is no evidence of catheter-related infection.
Underpricing of Venture-Backed and Non Venture-Backed Ipos: Germany's Neuer Market

This paper analyzes a comprehensive data set of 160 non venture-backed, 79 venture-backed and 61 bridge financed companies going public at Germany's Neuer Markt between March 1997 and March 2002. I examine whether these three types of issues differ with regard to issuer characteristics, balance sheet data or offering characteristics. Moreover, this empirical study contributes to the underpricing literature by focusing on the complementary or rather competing role of venture capitalists and underwriters in certifying the quality of a company when going public. Companies backed by a prestigious venture capitalist and/or underwritten by a top bank are expected to show less underpricing at the initial public offering (IPO) due to a reduced ex-ante uncertainty. This analysis provides evidence to the contrary: VC-backed IPOs appear to be more underpriced than non VC-backed IPOs.
Robust Mechanisms Under Common Valuation

I construct an informationally robust auction to sell a common‐value good. I examine the revenue guarantee of an auction over all information structures of bidders and all equilibria. As the number of bidders gets large, the revenue guarantee of my auction converges to the full surplus, regardless of how information changes as more bidders are added. My auction also maximizes the revenue guarantee when there is a single bidder.
SAND: Sectored-Antenna Neighbor Discovery Protocol for Wireless Networks

Directional antennas offer many potential advantages for wireless networks such as increased network capacity, extended transmission range and reduced energy consumption. Exploiting these advantages, however, requires new protocols and mechanisms at various communication layers to intelligently control the directional antenna system. With directional antennas, many trivial mechanisms, such as neighbor discovery, become more challenging since communicating parties must agree on where and when to point their directional beams to enable communication. In this paper, we propose a fully directional neighbor discovery protocol called Sectored-Antenna Neighbor Discovery (SAND) protocol. SAND is designed for sectored-antennas, a low-cost and simple realization of directional antennas, that utilize multiple limited beamwidth antennas. Unlike many proposed directional neighbor discovery protocols, SAND depends neither on omnidirectional antennas nor on time synchronization. In addition, SAND performs neighbor discovery in a serialized fashion allowing individual nodes to discover all potential neighbors within a predetermined time. Moreover, SAND guarantees the discovery of the best sector combination on both communication ends allowing more robust and higher reliability links. Finally, SAND gathers the neighborhood information in a centralized location, if needed, to be used by centralized networking protocols. The effectiveness of SAND has been assessed via simulation studies and real hardware implementation.
Investigate the influence of halloysite and activated carbon mixtures in phytostabilization of Pb-contaminated soil with Lolium perenne L.

Abstract A pot experiment was conducted to investigate the effects of halloysite and activated carbon mixtures on the biomass and distribution of macronutrients (Mg, K, Ca, Na, P) in ryegrass grown in Pb-contaminated soil. The soil was spiked with four different levels of lead contamination, i.e. 0 (control), 200, 400, 800 mg·kg−1 were applied in an analytical grade Pb(NO3)2 solution mixed thoroughly with the soil. Raw halloysite (3%) and activated carbon (1% relative to soil mass) mixtures were used to reduce the effect of soil lead contamination. Ryegrass of the Bokser variety was harvested after 42 days, and soil samples were collected for laboratory tests. The mixture of sorbents applied in the experiment which turned out to be most effective at doses of lead amounting to 400 and 800 mg·kg−1 of soil, with the increase in the yield of ryegrass being the highest. Increasing contamination of soil with lead in the series without the mixture of sorbents increased the contents of phosphorus, sodium, calcium and magnesium in ryegrass. The applied mixture of halloysite and activated carbon changed the macronutrient concentration in ryegrass, with the greatest changes found in that of potassium and sodium.
Conformational disturbance in Abl kinase upon mutation and deregulation

Protein dynamics are inextricably linked to protein function but there are few techniques that allow protein dynamics to be conveniently interrogated. For example, mutations and translocations give rise to aberrant proteins such as Bcr-Abl where changes in protein conformation and dynamics are believed to result in deregulated kinase activity that provides the oncogenic signal in chronic myelogeous leukemia. Although crystal structures of the down-regulated c-Abl kinase core have been reported, the conformational impact of mutations that render Abl resistant to small-molecule kinase inhibitors are largely unknown as is the allosteric interplay of the various regulatory elements of the protein. Hydrogen exchange mass spectrometry (HX MS) was used to compare the conformations of wild-type Abl with a nonmyristoylated form and with 3 clinically relevant imatinib resistance mutants (T315I, Y253H and E255V). A HX-resistant core localized to the interface between the SH2 and kinase domains, a region known to be important for maintaining the down-regulated state. Conformational differences upon demyristoylation were consistent with the SH2 domain moving to the top of the small lobe of the kinase domain as a function of activation. There were conformational changes in the T315I mutant but, surprisingly, no major changes in conformation were detected in either the Y253H or the E255V mutants. Taken together, these results provide evidence that allosteric interactions and conformational changes play a major role in Abl kinase regulation in solution. Similar analyses could be performed on any protein to provide mechanistic details about conformational changes and protein function.
Glucose and Fatty Acids Synergize to Promote B-Cell Apoptosis through Activation of Glycogen Synthase Kinase 3β Independent of JNK Activation

Background The combination of elevated glucose and free-fatty acids (FFA), prevalent in diabetes, has been suggested to be a major contributor to pancreatic β-cell death. This study examines the synergistic effects of glucose and FFA on β-cell apoptosis and the molecular mechanisms involved. Mouse insulinoma cells and primary islets were treated with palmitate at increasing glucose and effects on apoptosis, endoplasmic reticulum (ER) stress and insulin receptor substrate (IRS) signaling were examined. Principal Findings Increasing glucose (5–25 mM) with palmitate (400 µM) had synergistic effects on apoptosis. Jun NH2-terminal kinase (JNK) activation peaked at the lowest glucose concentration, in contrast to a progressive reduction in IRS2 protein and impairment of insulin receptor substrate signaling. A synergistic effect was observed on activation of ER stress markers, along with recruitment of SREBP1 to the nucleus. These findings were confirmed in primary islets. The above effects associated with an increase in glycogen synthase kinase 3β (Gsk3β) activity and were reversed along with apoptosis by an adenovirus expressing a kinase dead Gsk3β. Conclusions/Significance Glucose in the presence of FFA results in synergistic effects on ER stress, impaired insulin receptor substrate signaling and Gsk3β activation. The data support the importance of controlling both hyperglycemia and hyperlipidemia in the management of Type 2 diabetes, and identify pancreatic islet β-cell Gsk3β as a potential therapeutic target.
The opioid neuropeptides in uterine fibroid pseudocapsules: a putative association with cervical integrity in human reproduction

Abstract The myoma pseudocapsule (MP) is a fibro-vascular network rich of neurotransmitters, as a neurovascular bundle, surrounding fibroid and separating myoma from myometrium. We investigated the distribution of the opioid neuropeptides, as enkephalin (ENK) and oxytocin (OXT), in the nerve fibers within MP and their possible influence in human reproduction in 57 women. An histological and immunofluorescent staining of OXT and ENK was performed on nerve fibers of MP samples from the fundus, corpus and isthmian-cervical regions, with a successive morphometric quantification of OXT and ENK. None of the nerve fibers in the uterine fundus and corpus MPs contained ENK and the nerve fibers in the isthmian–cervical region demonstrated an ENK value of up to 94 ± 0.7 CU. A comparatively lower number of OXT-positive nerve fibers were found in the fundal MP (6.3 ± 0.8 CU). OXT-positive nerve fibers with OXT were marginally increased in corporal MP (15.0 ± 1.4 CU) and were substantially higher in the isthmian–cervical region MP (72.1 ± 5.1 CU) (p < 0.01). The distribution of OXY neurofibers showed a slight into the uterine corpus, while are highly present into the cervico-isthmic area, with influence on reproductive system and sexual disorders manifesting after surgical procedures on the cervix.
The fold of human aquaporin 1.

The fold of human aquaporin 1 is determined from cryo-electron microscopic data at 4.5 A resolution. The monomeric structure consists of two transmembrane triple helices arranged around a pseudo-2-fold axis connected by a long flexible extracellular loop. Each triplet contains between its second and third helix a functional loop containing the highly conserved fingerprint NPA motif. These functional loops are assumed to fold inwards between the two triplets, thereby forming the heart of the water channel. The helix topology was determined from the directionality pattern of each of the six transmembrane helices with respect to the membrane, together with constraints defined by the sequence and atomic force microscopy data. The directionality of the helices was determined by collecting the best-fitting orientations resulting from a search through the three-dimensional experimental map for a large number of alpha-helical fragments. Tests on cryo-electron crystallographic bacteriorhodopsin data suggest that our method is generally applicable to determine the topology of helical proteins for which only medium-resolution electron microscopy data are available.
Temporal and Hf isotope geochemical evolution of southern Finnish Lapland from 2.77 Ga to 1.76 Ga

The southern Finnish Lapland area in the central part of the Fennoscandian shield is a geologically complex zone comprising several Archean blocks and Paleoproterozoic supracrustal belts all of which are intruded by voluminous Paleoproterozoic granites (the central Lapland granitoid complex, CLGC). New in-situ single crystal zircon U–Pb age determinations coupled with Lu–Hf isotope data from the same zircons were acquired from five granitoid rocks and one amphibolitic rock sample from the southern Lapland area. The samples represent at least four distinct magmatic events (at ca. 2.77 Ga, 2.12 Ga, 1.81 Ga, and 1.76 Ga). The 2.77 Ga and the 1.81-1.76 Ga events have initial Hf isotope signatures implying that local Archean rocks represent the source for the younger granites. The 2.12 Ga event has a slightly more juvenile Hf isotope composition suggesting either that the source for the 2.12 Ga granites represents a different Archean block or that the source is composed of mixed Archean and Paleoproterozoic components. The Neoarchean source for the Paleoproterozoic granites may be traced through the CLGC all the way to the Jokkmokk area in Sweden and possibly to the Lofoten area in Norway.
Ultrashort echo time imaging using pointwise encoding time reduction with radial acquisition (PETRA)

Sequences with ultrashort echo times enable new applications of MRI, including bone, tendon, ligament, and dental imaging. In this article, a sequence is presented that achieves the shortest possible encoding time for each k‐space point, limited by pulse length, hardware switching times, and gradient performance of the scanner. In pointwise encoding time reduction with radial acquisition (PETRA), outer k‐space is filled with radial half‐projections, whereas the centre is measured single pointwise on a Cartesian trajectory. This hybrid sequence combines the features of single point imaging with radial projection imaging. No hardware changes are required. Using this method, 3D images with an isotropic resolution of 1 mm can be obtained in less than 3 minutes. The differences between PETRA and the ultrashort echo time (UTE) sequence are evaluated by simulation and phantom measurements. Advantages of pointwise encoding time reduction with radial acquisition are shown for tissue with a T2 below 1 ms. The signal to noise ratio and Contrast‐to‐noise ratio (CNR) performance, as well as possible limitations of the approach, are investigated. In‐vivo head, knee, ankle, and wrist examples are presented to prove the feasibility of the sequence. In summary, fast imaging with ultrashort echo time is enabled by PETRA and may help to establish new routine clinical applications of ultrashort echo time sequences. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
Courtship rate signals fertility in an externally fertilizing fish

Sperm limitation is widespread across many animal species. Several mechanisms of sperm allocation have been proposed, including optimal allocation according to clutch size and equal allocation across females. However, considerably less effort has been directed at investigating the behavioural signals associated with sperm limitation in males, which may include mating rate and the intensity of courtship. We investigated whether multiple successive spawnings affect individual male fertilization success, mating rates and courtship rates in Japanese medaka (Oryzias latipes). Across an average of 17 spawning events per male, fertilization success decreased from 83.7 per cent for the first spawning to 40 per cent for the last spawning while courtship rate decreased from 3.4 to 1.5 min−1. Females appeared to respond to male sperm depletion by reducing clutch size. Our results suggest that male Japanese medaka are sperm-limited, and that courtship rate may be an honest indication of fertilization ability.
Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity*

Lec13 cells, a variant Chinese hamster ovary cell line, were used to produce human IgG1 that were deficient in fucose attached to the Asn297-linked carbohydrate but were otherwise similar to that found in IgG1 produced in normal Chinese hamster ovary cell lines and from human serum. Lack of fucose on the IgG1 had no effect on binding to human FcγRI, C1q, or the neonatal Fc receptor. Although no change in affinity was found for the His131 polymorphic form of human FcγRIIA, a slight improvement in binding was evident for FcγRIIB and the Arg131 FcγRIIA polymorphic form. In contrast, binding of the fucose-deficient IgG1 to human FcγRIIIA was improved up to 50-fold. Antibody-dependent cellular cytotoxicity assays using purified peripheral blood monocytes or natural killer cells from several donors showed enhanced cytotoxicity, especially evident at lower antibody concentrations. When combined with an IgG1 Fc protein variant that exhibited enhanced antibody-dependent cellular cytotoxicity, the lack of fucose was synergistic.
EEG-Based Learning System for Online Motion Sickness Level Estimation in a Dynamic Vehicle Environment

Motion sickness is a common experience for many people. Several previous researches indicated that motion sickness has a negative effect on driving performance and sometimes leads to serious traffic accidents because of a decline in a person's ability to maintain self-control. This safety issue has motivated us to find a way to prevent vehicle accidents. Our target was to determine a set of valid motion sickness indicators that would predict the occurrence of a person's motion sickness as soon as possible. A successful method for the early detection of motion sickness will help us to construct a cognitive monitoring system. Such a monitoring system can alert people before they become sick and prevent them from being distracted by various motion sickness symptoms while driving or riding in a car. In our past researches, we investigated the physiological changes that occur during the transition of a passenger's cognitive state using electroencephalography (EEG) power spectrum analysis, and we found that the EEG power responses in the left and right motors, parietal, lateral occipital, and occipital midline brain areas were more highly correlated to subjective sickness levels than other brain areas. In this paper, we propose the use of a self-organizing neural fuzzy inference network (SONFIN) to estimate a driver's/passenger's sickness level based on EEG features that have been extracted online from five motion sickness-related brain areas, while either in real or virtual vehicle environments. The results show that our proposed learning system is capable of extracting a set of valid motion sickness indicators that originated from EEG dynamics, and through SONFIN, a neuro-fuzzy prediction model, we successfully translated the set of motion sickness indicators into motion sickness levels. The overall performance of this proposed EEG-based learning system can achieve an average prediction accuracy of ~82%.