Miracle-dz/UniFAR-FTUs huggingface dataset:
Similarity-based evolution control for fitness estimation in particle swarm optimization

Evolution control in the surrogate-assisted evolutionary and other meta-heuristic optimization algorithms is essential for their success in efficiently achieving the global optimum. In order to further reduce the number of fitness evaluations, a similarity-based evolution control method is introduced into the fitness estimation strategy for particle swarm optimization (FESPSO) [1]. In the proposed method, the fitness of a particle is either estimated or evaluated, depending on its similarity to the particle whose fitness is known. The performance of the proposed algorithm is examined on eight benchmark problems, and the simulation results show that the proposed algorithm is highly competitive on reducing the number of required fitness evaluations using the computationally expensive fitness function.
Predicting Bankruptcy with Robust Logistic Regression

Using financial ratio data from 2006 and 2007, this study uses a three-fold cross validation scheme to compare the classification and pre- diction of bankrupt firms by robust logistic regression with the Bianco and Yohai (BY) estimator versus maximum likelihood (ML) logistic regression. With both the 2006 and 2007 data, BY robust logistic regression improves both the classification of bankrupt firms in the training set and the prediction of bankrupt firms in the testing set. In an out of sample test, the BY robust logistic regression correctly predicts bankruptcy for Lehman Brothers; however, the ML logistic regression never predicts bankruptcy for Lehman Brothers with either the 2006 or 2007 data. Our analysis indicates that if the BY robust logistic regression significantly changes the estimated regression coefficients from ML logistic regression, then the BY robust logistic regression method can significantly improve the classification and prediction of bankrupt firms. At worst, the BY robust logistic regression makes no changes in the estimated regression coefficients and has the same classification and prediction results as ML logistic regression. This is strong evidence that BY robust logistic regression should be used as a robustness check on ML logistic regression, and if a difference exists, then BY robust logistic regression should be used as the primary classifier.
Skeleton-based gyri sulci separation for improved assessment of cortical thickness

In order to improve classification of neurological diseases involving cortical thinning, this work proposes an approach for separating gyral and sulcal regions of the human cortex. Using data from magnetic resonance imaging, the skeleton of the brain's white matter was reconstructed and a geodesic distance measure was applied to separate gyri and sulci. Cortical thickness per subregion was measured for the entire cortex and for gyri and sulci individually in 21 patients with Alzheimer's disease, 10 patients with frontotemporal lobar degeneration composed of two subgroups and 13 control subjects. For discrimination using logistic regressions, which was assessed using leave-one-out cross-validation, improved results were obtained in five out of six group comparisons when cortical thickness measurements were constrained to gyral or sulcal regions.
A Study of Information Retrieval Weighting Schemes for Sentiment Analysis

Most sentiment analysis approaches use as baseline a support vector machines (SVM) classifier with binary unigram weights. In this paper, we explore whether more sophisticated feature weighting schemes from Information Retrieval can enhance classification accuracy. We show that variants of the classic tf.idf scheme adapted to sentiment analysis provide significant increases in accuracy, especially when using a sublinear function for term frequency weights and document frequency smoothing. The techniques are tested on a wide selection of data sets and produce the best accuracy to our knowledge.
Physical, chemical, and mineralogical properties of some salt affected soils of Rajasthan, India /

3. When a map, drawing or chart, etc., was part of the material being photographed the photographer followed a definite method in "sectioning" the material. It is customary to begin photoing at the upper left hand corner of a targe sheet and to continue photoing from left to right in equal sections with a small overlap. If necessary, sectioning is continued again — beginning below the first row and continuing on until complete.
The Facebook Paths to Happiness: Effects of the Number of Facebook Friends and Self-Presentation on Subjective Well-Being

The current study investigates whether and how Facebook increases college-age users' subjective well-being by focusing on the number of Facebook friends and self-presentation strategies (positive vs. honest). A structural equation modeling analysis of cross-sectional survey data of college student Facebook users (N=391) revealed that the number of Facebook friends had a positive association with subjective well-being, but this association was not mediated by perceived social support. Additionally, we found that there was a negative curvilinear (inverted U-shape curve) relationship between Facebook friends and perceived social support. As for self-presentation strategies, whereas positive self-presentation had a direct effect on subjective well-being, honest self-presentation had a significant indirect effect on subjective well-being through perceived social support. Our study suggests that the number of Facebook friends and positive self-presentation may enhance users' subjective well-being, but this portion of happiness may not be grounded in perceived social support. On the other hand, honest self-presentation may enhance happiness rooted in social support provided by Facebook friends. Implications of our findings are discussed in light of affirmation of self-worth, time and effort required for building and maintaining friendships, and the important role played by self-disclosure in signaling one's need for social support.
Extensive Tonotopic Mapping across Auditory Cortex Is Recapitulated by Spectrally Directed Attention and Systematically Related to Cortical Myeloarchitecture

Auditory selective attention is vital in natural soundscapes. But it is unclear how attentional focus on the primary dimension of auditory representation—acoustic frequency—might modulate basic auditory functional topography during active listening. In contrast to visual selective attention, which is supported by motor-mediated optimization of input across saccades and pupil dilation, the primate auditory system has fewer means of differentially sampling the world. This makes spectrally-directed endogenous attention a particularly crucial aspect of auditory attention. Using a novel functional paradigm combined with quantitative MRI, we establish in male and female listeners that human frequency-band-selective attention drives activation in both myeloarchitectonically estimated auditory core, and across the majority of tonotopically mapped nonprimary auditory cortex. The attentionally driven best-frequency maps show strong concordance with sensory-driven maps in the same subjects across much of the temporal plane, with poor concordance in areas outside traditional auditory cortex. There is significantly greater activation across most of auditory cortex when best frequency is attended, versus ignored; the same regions do not show this enhancement when attending to the least-preferred frequency band. Finally, the results demonstrate that there is spatial correspondence between the degree of myelination and the strength of the tonotopic signal across a number of regions in auditory cortex. Strong frequency preferences across tonotopically mapped auditory cortex spatially correlate with R1-estimated myeloarchitecture, indicating shared functional and anatomical organization that may underlie intrinsic auditory regionalization. SIGNIFICANCE STATEMENT Perception is an active process, especially sensitive to attentional state. Listeners direct auditory attention to track a violin's melody within an ensemble performance, or to follow a voice in a crowded cafe. Although diverse pathologies reduce quality of life by impacting such spectrally directed auditory attention, its neurobiological bases are unclear. We demonstrate that human primary and nonprimary auditory cortical activation is modulated by spectrally directed attention in a manner that recapitulates its tonotopic sensory organization. Further, the graded activation profiles evoked by single-frequency bands are correlated with attentionally driven activation when these bands are presented in complex soundscapes. Finally, we observe a strong concordance in the degree of cortical myelination and the strength of tonotopic activation across several auditory cortical regions.
MX2, a morpholino anthracycline, as a new antitumor agent against drug-sensitive and multidrug-resistant human and murine tumor cells.

MX2, a new morpholino anthracycline, showed similar or superior chemotherapeutic effects to Adriamycin (ADM) against several experimental murine tumors. i.v. administration of MX2 against L1210-bearing mice induced a prolongation of life-span by twice or more compared to ADM. MX2 was equally or slightly more effective against Lewis lung carcinoma and colon adenocarcinomas 26 and 38 than ADM when either drug was given i.v. The antitumor activity of MX2 against human tumor xenografts was similar to that of ADM, and the compound was effective against three out of four gastric adenocarcinomas, one out of two non-small-cell lung carcinomas, and two out of two mammary adenocarcinomas. In particular, this compound exhibited a marked effect against MX-1, a human mammary adenocarcinoma. MX2, in contrast to ADM, was effective against sublines of P388 leukemia resistant to ADM or aclacinomycin A in vivo as well as in vitro. A maximum percentage increase in life-span of about 90% was obtained in mice bearing these resistant tumors. MX2 is a unique anthracycline antibiotic effective on drug-sensitive as well as multidrug-resistant murine and human cells.
Non-Invasive Monitoring of Cardiac Output in Critical Care Medicine

Critically ill patients require close hemodynamic monitoring to titrate treatment on a regular basis. It allows administering fluid with parsimony and adjusting inotropes and vasoactive drugs when necessary. Although invasive monitoring is considered as the reference method, non-invasive monitoring presents the obvious advantage of being associated with fewer complications, at the expanse of accuracy, precision, and step-response change. A great many methods and devices are now used over the world, and this article focuses on several of them, providing with a brief review of related underlying physical principles and validation articles analysis. Reviewed methods include electrical bioimpedance and bioreactance, respiratory-derived cardiac output (CO) monitoring technique, pulse wave transit time, ultrasound CO monitoring, multimodal algorithmic estimation, and inductance thoracocardiography. Quality criteria with which devices were reviewed included: accuracy (closeness of agreement between a measurement value and a true value of the measured), precision (closeness of agreement between replicate measurements on the same or similar objects under specified conditions), and step response change (delay between physiological change and its indication). Our conclusion is that the offer of non-invasive monitoring has improved in the past few years, even though further developments are needed to provide clinicians with sufficiently accurate devices for routine use, as alternative to invasive monitoring devices.
Maximum entropy distributions on graphs

Inspired by the problem of sensory coding in neuroscience, we study the maximum entropy distribution on weighted graphs with a given expected degree sequence. This distribution on graphs is characterized by independent edge weights parameterized by vertex potentials at each node. Using the general theory of exponential family distributions, we prove the existence and uniqueness of the maximum likelihood estimator (MLE) of the vertex parameters. We also prove the consistency of the MLE from a single graph sample, extending the results of Chatterjee, Diaconis, and Sly for unweighted (binary) graphs. Interestingly, our extensions require an intricate study of the inverses of diagonally dominant positive matrices. Along the way, we derive analogues of the Erd}os-Gallai criterion of graphical sequences for weighted graphs.
Biological diversity versus risk for mosquito nuisance and disease transmission in constructed wetlands in southern Sweden

Abstract. In southern Sweden, many wetlands have been constructed, and maintaining or increasing biological diversity is often included in the aims. Some wetlands are constructed near human settlements, thus raising the problem of wetlands being associated with mosquitoes (Diptera: Culicidae). Increased biodiversity (including mosquito diversity) is considered desirable, whereas mosquito nuisance from a human point of view is not. Adult mosquito abundance, diversity and species assemblages of constructed wetlands were compared to natural wetlands. The potential of constructed wetlands for mosquito nuisance and transmission of mosquito‐borne viruses was evaluated. The study areas included five constructed and four natural wetlands. Mosquito abundance and species richness were higher in the natural than in the constructed wetlands, and showed a positive correlation with wetland size. Mosquito species assemblages formed three clusters, which were not explained by origin, size and water permanence of wetlands. In a redundancy analysis, however, mosquito faunas showed significant relationships with these variables, and size and origin of wetlands were most important. Major nuisance species (multivoltine species feeding on mammals and laying eggs on soil) were found in all wetlands, although in relatively low numbers. Risk assessment for Sindbis virus transmission showed moderate risk for two constructed wetlands near human settlements. It is concluded that small size of constructed wetlands has the advantage of low mosquito numbers from a human point of view. The use of functional groups is recommended as a tool for presenting mosquito data to the public, and for helping communication between scientists and administrative decision makers.
Sea-ice area variability and trends in Arctic sectors of different morphology, 1996–2015

ABSTRACT This study presents a comparison of the sea-ice cover of the whole Arctic Ocean with two arctic sectors of different morphology: the Greenland Sea, as a typical “open sea”, and the Beaufort Sea, as a typical “closed sea”. The study refers to the period January 1996–December 2015 and makes use of the Arctic sea-ice concentration data set produced, on a daily basis, by the Institute of Environmental Physics of the University of Bremen. From the whole Arctic data set, two subsets, covering the Greenland Sea and the Beaufort Sea, were extracted. The extent of sea-ice cover was obtained by the sea-ice area (SIA) parameter, which was computed according to the conventional NASA method. Our analysis shows that the strong summer decline of the Arctic SIA in the last 20 years is not observed in the Greenland Sea (the trend of SIA minimum values is ) while it is even greater in the Beaufort Sea.
Combined dorsal and volar plate fixation of complex fractures of the distal part of the radius.

BACKGROUND Fractures of the distal part of the radius that are associated with complex comminution of both the articular surface and the metaphysis (subgroup C3.2 according to the Comprehensive Classification of Fractures) are a challenge for surgeons using standard operative techniques. METHODS Twenty-five patients with subgroup-C3.2 fractures that had been treated with combined dorsal and volar plate fixation were evaluated at an average of twenty-six months after the injury. Subsequent procedures included implant removal in twenty-one patients and reconstruction of a ruptured tendon in two patients. RESULTS An average of 54 degrees of extension, 51 degrees of flexion, 79 degrees of pronation, and 74 degrees of supination were achieved. The grip strength in the involved limb was an average of 78% of that in the contralateral limb. The average radiographic measurements were 2 degrees of dorsal angulation, 21 degrees of ulnar inclination, 0.8 mm of positive ulnar variance, and 0.7 mm of articular incongruity. Seven patients had radiographic signs of arthrosis during the follow-up period. A good or excellent functional result was achieved for twenty-four patients (96%) according to the rating system of Gartland and Werley and for ten patients (40%) according to the more stringent modified system of Green and O'Brien. CONCLUSIONS Combined dorsal and volar plate fixation of the distal part of the radius can achieve a stable, mobile wrist in patients with very complex fractures. The results are limited by the severity of the injury and may deteriorate with longer follow-up. A second operation for implant removal is common, and there is a small risk of tendon-related complications.
Tenascin-C expression by fibroblasts is elevated in stressed collagen gels

Chick embryo fibroblasts cultured on a collagen matrix exert tractional forces leading to the contraction of unrestrained, floating collagen gels and to the development of tension in attached, restrained gels. On a restrained, attached collagen gel the fibroblasts synthesize large quantities of tenascin-C, whereas in a floating, contracting gel tenascin-C synthesis is decreased. This regulation of tenascin-C synthesis can be observed by the secretion of metabolically labeled tenascin-C into the conditioned medium, as well as by the deposition of tenascin-C into the collagen matrix as judged by immunofluorescence. Regulation appears to occur at the transcriptional level, because when cells on attached or floating collagen gels are transfected with promoter constructs of the tenascin-C gene, luciferase expression driven by the tenascin-C promoter parallels the effects measured for endogenous tenascin-C synthesis, whereas luciferase expression under the control of the SV40 promoter does not depend on the state of the collagen gel. The promoter region responsible for tenascin-C induction on attached collagen gels is distinct from the region important for the induction of tenascin-C by serum, and may define a novel kind of response element. By joining this tenascin-C sequence to the SV40 promoter of a reporter plasmid, its activity can be transferred to the heterologous promoter. We propose that the tenascin-C promoter is directly or indirectly activated in fibroblasts generating and experiencing mechanical stress within a restrained collagen matrix. This may be an important aspect of the regulation of tenascin-C expression during embryogenesis as well as during wound healing and other regenerative and morphogenetic processes.
Using administrative databases to measure waiting times for patients undergoing major cancer surgery in Ontario, 1993-2000.

PURPOSE To determine how long patients in Ontario waited for major breast, colorectal, lung or prostate cancer surgery in the years 1993-2000. METHODS "Surgical waiting time" was defined as the interval from date of preoperative surgeon consult to date of hospital admission for surgery. We created patient cohorts by linking appropriate diagnosis and procedure codes from Canadian Institutes of Health Information data. Scrambled unique surgeon identifiers were obtained from Ontario Health Insurance Plan data. Changes in median surgical waiting times were assessed with univariate time-trend analyses and multilevel models. Models were controlled for year of surgery and other patient (age, gender, comorbid conditions, income level, area of residence) and hospital level characteristics (teaching status, procedure volume status). RESULTS Compared with 1993, median surgical waiting times in the year 2000 increased 36% for patients with breast cancer (to 19 d), 46% with colorectal (to 19 d), 36% with lung (to 34 d) and 4% with prostate cancer (to 83 d). Multilevel models confirmed significant increases in waiting times for all procedures. There were no concerning or consistent differences in waiting times among the categories of hospitals and patients examined. DISCUSSION There were significant increases in surgical waiting times among patients undergoing breast, colorectal, lung or prostate cancer surgery in Ontario over years 1993-2000. Administrative databases can be used to efficiently measure such waits.
Tissue plasminogen activator‐mediated PDGF signaling and neurovascular coupling in stroke

Summary. The use of tissue plasminogen activator (tPA) as a thrombolytic treatment in ischemic stroke is limited largely due to concerns for hemorrhagic complications. The underlying mechanisms are still unknown, but evidence is beginning to emerge that tPA interacts with key regulators of the neurovascular unit (NVU), and that these interactions may contribute to the undesirable side effects associated with the use of tPA in ischemic stroke. Understanding these connections and tPA’s normal function within the NVU may offer new insights into future therapeutic approaches.
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma

Aldosterone-producing adenomas (APAs) are benign tumors of the adrenal gland that constitutively produce the salt-retaining steroid hormone aldosterone and cause millions of cases of severe hypertension worldwide. Either of 2 somatic mutations in the potassium channel KCNJ5 (G151R and L168R, hereafter referred to as KCNJ5MUT) in adrenocortical cells account for half of APAs worldwide. These mutations alter channel selectivity to allow abnormal Na+ conductance, resulting in membrane depolarization, calcium influx, aldosterone production, and cell proliferation. Because APA diagnosis requires a difficult invasive procedure, patients often remain undiagnosed and inadequately treated. Inhibitors of KCNJ5MUT could allow noninvasive diagnosis and therapy of APAs carrying KCNJ5 mutations. Here, we developed a high-throughput screen for rescue of KCNJ5MUT-induced lethality and identified a series of macrolide antibiotics, including roxithromycin, that potently inhibit KCNJ5MUT, but not KCNJ5WT. Electrophysiology demonstrated direct KCNJ5MUT inhibition. In human aldosterone-producing adrenocortical cancer cell lines, roxithromycin inhibited KCNJ5MUT-induced induction of CYP11B2 (encoding aldosterone synthase) expression and aldosterone production. Further exploration of macrolides showed that KCNJ5MUT was similarly selectively inhibited by idremcinal, a macrolide motilin receptor agonist, and by synthesized macrolide derivatives lacking antibiotic or motilide activity. Macrolide-derived selective KCNJ5MUT inhibitors thus have the potential to advance the diagnosis and treatment of APAs harboring KCNJ5MUT.
On Development and Evaluation of Prototype Mobile Decision Support for Hospital Triage

Ambiguous triage scenarios in hospital emergency departments are often difficult to assess without decision support. Subjective assessments of such scenarios can either lead to under-triaging or over-triaging for which true conditions of patients are often not addressed within the required time. In this paper, we propose a decision support model that can guide a clinician when identifying the urgency of medical intervention when patient presents with ambiguous triage case. Our model is a heuristic approach that selects the best triage category, identifies corresponding discriminating attribute of the patient, and allows clinician to attach a level of confidence in the decision. We implemented this model as a mobile decision support system, called iTriage. Results of an initial evaluation of iTriage using fourteen paper-based adult triage scenarios showed that our model produced robust decisions for urgent scenarios. For non-urgent scenarios, the proposed model provided guidance especially when the scenarios were ambiguously stated.