Miracle-dz/UniFAR-FTUs huggingface dataset:
Relations between Unsociability and Peer Problems in Chinese Children: Moderating Effect of Behavioural Control

Unsociable children are likely to develop adjustment difficulties in Chinese society. The primary goal of the present study was to examine the moderating effect of behavioural control on the relation between unsociability and peer problems in Chinese children. Participants were fourth to eighth grade students in urban China (N = 787). Assessments of unsociability, shyness, peer problems and behavioural control were obtained from peer nominations and teacher ratings. Results indicated that unsociability was positively related to peer problems in Chinese children after controlling for shyness. Also, the relation between unsociability and peer problems was attenuated among children with higher behavioural control. Thus, behavioural control may be a buffering factor that serves to protect unsociable children from developing peer problems. Gender and age also moderated these associations. Results are discussed in terms of the meaning and implications of unsociability and behavioural control in Chinese culture. Copyright © 2014 John Wiley & Sons, Ltd.
An activator of glutamate decarboxylase genes regulates the expression of enteropathogenic Escherichia coli virulence genes through control of the plasmid‐encoded regulator, Per

Enteropathogenic Escherichia coli (EPEC) is a major cause of infantile diarrhoea in a number of developing countries and is the prototype of pathogenic bacteria that cause attaching and effacing (A/E) intestinal lesions. A chromosomal pathogenicity island, termed the locus of enterocyte effacement (LEE), contains all the genes necessary for the A/E phenotype as well as genes for a type III secretion system and intimate adhesion. Genes in the LEE and genes involved in the synthesis of bundle‐forming pili (BFP) are positively regulated by the plasmid‐encoded regulator (Per) and comprise the per regulon. In order to identify factors that control the per regulon, we screened an EPEC genomic library for clones that modulate the expression of per. A plasmid clone that decreased the expression of per was isolated using a lacZ reporter gene fused to the per promoter. Subcloning revealed that YhiX, a putative AraC/XylR family transcriptional regulator, was the effector of per repression. Through downregulation of per, a plasmid overproducing YhiX reduced the synthesis of intimin, BfpA, Tir, and CesT, factors important for EPEC virulence. yhiX is located downstream of gadA, which encodes glutamate decarboxylase, an enzyme involved in acid resistance of E. coli. YhiX was found to be an activator of gadA, and the cloned yhiX gene increased production of glutamate decarboxylases (GAD) and activated the transcription of the gadA and gadB promoters. Therefore, yhiX was renamed gadX. Analysis of a gadX mutant grown in the different culture media with acidic and alkaline pH showed that regulation of perA, gadA and gadB by GadX was altered by the external pH and the culture media condition. Under conditions in which EPEC infects cultured epithelial cells, GadX negatively regulated perA expression, and the derepression in the gadX mutant increased translocation of Tir into epithelial cells relative to wild‐type EPEC. DNA mobility shift experiments showed that purified GadX protein bound to the perA, gadA and gadB promoter regions in vitro, indicating that GadX is a transcriptional regulator of these genes. On the basis of these results, we propose that GadX may be involved in the appropriate expression of genes required for acid resistance and virulence of EPEC. Our data are consistent with a model in which environmental changes resulting from passage from the stomach to the proximal small intestine induce the functional effect of GadX on per and GAD expression in order to prevent inappropriate expression of the products of these two systems.
Work engagement of older registered nurses: the impact of a caring-based intervention.

AIM The aim of this evaluation research was to measure the impact of a caring-based intervention on the level of work engagement in older nurses. BACKGROUND Every effort is needed to retain older nurses at the bedside by assisting them to revitalise the internal motivation and self- reward that brought them to nursing. METHOD A mixed method evaluation research approach using both qualitative and quantitative measurements was used to determine the impact of a caring-based programme on improving the work engagement scores of older Registered Nurses (RNs). RESULT The results of this study suggest that leadership strategies aimed at improving work engagement using caring theories have a significant positive impact. CONCLUSION The findings contribute to our understanding of how work engagement can be enhanced through building work environments where there is a sense of belonging and teamwork, where staff are allowed time to decompress as well as build positive work relationships. IMPLICATIONS FOR NURSING MANAGEMENT Nurse Leaders (NLs) bear a responsibility to partner with older Registered Nurses (RNs) to build engagement in their work life while enhancing the quality of care. Successful leaders will find ways to meet these unique challenges by creating a healthy work environment.
Individualization, gender and cultural work

In the ‘new’ economy the virtues of creative and cultural industry production are widely promoted and idealized. For women, set free from their‘feudal chains’, the ‘cool creative and egalitarian’ cultural economy — particularly in areas such new media, music, design and fashion — appears to offer paths to workplace freedom. But is this really so? Using evidence from the digital ‘new media’ sector, this article builds on the work of Lash and Adkins that suggests that the ostensibly detraditionalized cultural economy continues to play host to some markedly regressive traditional social structures. In particular it is shown how the new media sector exhibits some clear continuity with the old economy in terms of some enduring gender inequality and discrimination. However, more positively, evidence is presented of how women have been able to take advantage of individualized workplace structures
Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro

Background Hematopoietic stem cells located in the bone marrow interact with a specific microenvironment referred to as the stem cell niche. Data derived from ex vivo co-culture systems using mesenchymal stromal cells as a feeder cell layer suggest that cell-to-cell contact has a significant impact on the expansion, migratory potential and ‘stemness’ of hematopoietic stem cells. Here we investigated in detail the spatial relationship between hematopoietic stem cells and mesenchymal stromal cells during ex vivo expansion. Design and Methods In the co-culture system, we defined three distinct localizations of hematopoietic stem cells relative to the mesenchymal stromal cell layer: (i) those in supernatant (non-adherent cells); (ii) those adhering to the surface of mesenchymal stromal cells (phase-bright cells) and (iii) those beneath the mesenchymal stromal cells (phase-dim cells). Cell cycle, proliferation, cell division and immunophenotype of these three cell fractions were evaluated from day 1 to 7. Results Phase-bright cells contained the highest proportion of cycling progenitors during co-culture. In contrast, phase-dim cells divided much more slowly and retained a more immature phenotype compared to the other cell fractions. The phase-dim compartment was soon enriched for CD34+/CD38− cells. Migration beneath the mesenchymal stromal cell layer could be hampered by inhibiting integrin β1 or CXCR4. Conclusions Our data suggest that the mesenchymal stromal cell surface is the predominant site of proliferation of hematopoietic stem cells, whereas the compartment beneath the mesenchymal stromal cell layer seems to mimic the stem cell niche for more immature cells. The SDF-1/CXCR4 interaction and integrin-mediated cell adhesion play important roles in the distribution of hematopoietic stem cells in the co-culture system.
Learning To Understand Web Site Update Requests

We experimentally evaluate components of a system that learns to analyze natural-language requests to update information on a database-backed website. Our long-term goal is to develop a system which can adapt to changes in the distribution of requests as the underlying database schema changes—in short, a system that performs deep analysis of text in a domain of discourse that is limited, but which grows over time. We describe a scheme for decomposing request-understanding into a sequence of entity recognition and text classification tasks, each of which can be solved using standard learning methods. We then present experimental results that quantify how well these tasks can be learned.
From the SelectedWorks of Marcel Adam Just 2008 fMRI investigation of working memory for faces in autism : Visual coding and underconnectivity with frontal areas

Brain activation and functional connectivity were investigated in high functioning autism using functional magnetic resonance imaging in an n-back working memory task involving photographic face stimuli. The autism group showed reliably lower activation compared with controls in the inferior left prefrontal area (involved in verbal processing and working memory maintenance) and the right posterior temporal area (associated with theory of mind processing). The participants with autism also showed activation in a somewhat different location in the fusiform area than the control participants. These results suggest that the neural circuitry of the brain for face processing in autism may be analyzing the features of the face more as objects and less in terms of their human significance. The functional connectivity results revealed that the abnormal fusiform activation was embedded in a larger context of smaller and less synchronized networks, particularly indicating lower functional connectivity with frontal areas. In contrast to the underconnectivity with frontal areas, the autism group showed no underconnectivity among posterior cortical regions. These results extend previous findings of abnormal face perception in autism by demonstrating that the abnormalities are embedded in an abnormal cortical network that manages to perform the working memory task proficiently, using a visually oriented, asocial processing style that minimizes reliance on prefrontal areas.
Sovereign Risk, FDI Spillovers, and Growth

This paper studies the effect of sovereign risk on capital flows from rich to poor nations in the context of a two-country model, where Foreign Direct Investment (FDI) creates positive externalities in domestic production. We show that if externalities are large, a developing country never expropriates foreign assets, and behaves as under perfect enforcement of foreigners' property rights, jumping to the steady state in one period. If externalities are absent, a developing country always expropriates foreign assets and, then, there are no capital flows in equilibrium, as occurs in autarky. If externalities are of a medium size, our model can account for scarce capital flows from rich to poor nations, as well as other key features of the data, such as rising-over-time patterns of foreign capital and FDI in developing countries. In addition, the model offers an economic rationale for the FDI restrictions observed across nations.
Selective Deletion of Astroglial FMRP Dysregulates Glutamate Transporter GLT1 and Contributes to Fragile X Syndrome Phenotypes In Vivo

How the loss of fragile X mental retardation protein (FMRP) in different brain cell types, especially in non-neuron glial cells, induces fragile X syndrome (FXS) phenotypes has just begun to be understood. In the current study, we generated inducible astrocyte-specific Fmr1 conditional knock-out mice (i-astro-Fmr1-cKO) and restoration mice (i-astro-Fmr1-cON) to study the in vivo modulation of FXS synaptic phenotypes by astroglial FMRP. We found that functional expression of glutamate transporter GLT1 is 40% decreased in i-astro-Fmr1-cKO somatosensory cortical astrocytes in vivo, which can be fully rescued by the selective re-expression of FMRP in astrocytes in i-astro-Fmr1-cON mice. Although the selective loss of astroglial FMRP only modestly increases spine density and length in cortical pyramidal neurons, selective re-expression of FMRP in astrocytes significantly attenuates abnormal spine morphology in these neurons of i-astro-Fmr1-cON mice. Moreover, we found that basal protein synthesis levels and immunoreactivity of phosphorylated S6 ribosomal protein (p-s6P) is significantly increased in i-astro-Fmr1-cKO mice, while the enhanced cortical protein synthesis observed in Fmr1 KO mice is mitigated in i-astro-Fmr1-cON mice. Furthermore, ceftriaxone-mediated upregulation of surface GLT1 expression restores functional glutamate uptake and attenuates enhanced neuronal excitability in Fmr1 KO mice. In particular, ceftriaxone significantly decreases the growth rate of abnormally accelerated body weight and completely corrects spine abnormality in Fmr1 KO mice. Together, these results show that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS, presumably through dysregulated astroglial glutamate transporter GLT1 and impaired glutamate uptake. These results suggest the involvement of astrocyte-mediated mechanisms in the pathogenesis of FXS. SIGNIFICANCE STATEMENT Previous studies to understand how the loss of function of fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS) have largely focused on neurons; whether the selective loss of astroglial FMRP in vivo alters astrocyte functions and contributes to the pathogenesis of FXS remain essentially unknown. This has become a long-standing unanswered question in the fragile X field, which is also relevant to autism pathogenesis. Our current study generated astrocyte-specific Fmr1 conditional knock-out and restoration mice, and provided compelling evidence that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS, likely through the dysregulated astroglial glutamate transporter GLT1 expression and impaired glutamate uptake. These results demonstrate previously undescribed astrocyte-mediated mechanisms in the pathogenesis of FXS.
Why do Students Still Bother Coming to Lectures, When Everything is Available Online?

Web-based lecture technologies (WBLTs), which deliver recorded lectures and notes online, are increasingly common. However, there is concern that they may reduce lecture attendance. Since we did not observe a significant drop in attendance following the introduction of WBLTs in the School of Molecular Bioscience at the University of Sydney, we surveyed 563 students to discover why they attended lectures despite the availability of copious online materials. 82 % of responding students reported they always or mostly attend lectures and 74% expressed a negative emotion when asked how they would feel if lectures were abolished. Free-form comments indicated that students attend lectures for reasons either positive about lectures or negative about WBLTs. Students feel that lectures provide a disciplined learning environment where they can concentrate in a scholarly community. Lectures intrinsically contribute to the ‘university experience’ and the social aspect is also important. Some students are motivated to attend through habit, guilt or by financial concerns. Negative comments highlighted perceptions that WBLTs do not fully capture lecture content, can be inefficient and unreliable, and predispose students to procrastination. The majority of students use WBLTs in addition to attending lectures and perceive distinct roles for each mode. Most students who did not attend lectures claimed they were unable to for logistical reasons, although some cited inconvenience, overcrowding or peer-distraction. Students also make strategic decisions to prioritise competing commitments. Only a minority of students prefer WBLTs to attendance. These students prefer the ability to work at a time, place and pace of their choosing. This study supports the contention that WBLTs alone do not reduce lecture attendance, and highlights features of lectures which can be improved to increase attendance and student engagement.
The psychological and social impact of disability

Marinelli and Dell Orto continue the premise of their earlier editions of this widely adopted text and present a realistic perspective on disability. Carefully selected articles and personal narratives capture the unique aspects of the psychological and social effects of disability. Formatted to include thought-provoking study questions and disability awareness exercises, this text is recommended for students in rehabilitation counseling and physical therapy education programs, as well as professionals in rehabilitation, psychology, and social work.
Sustained-release G-CSF microspheres using a novel solid-in-oil-in-oil-in-water emulsion method

Background The main treatments for cancers are still chemotherapy and radiotherapy for intermediate-stage cancer and terminal cancer. However, the therapeutic methods often result in a decreased neutrophilic granulocyte count and other side effects. In this study, in order to improve the neutrophilic granulocyte levels in the blood after radiotherapy and chemotherapy, we developed a sustained-release granulocyte colony–stimulating factor (G-CSF) microsphere formulation using a novel solid-in-oil-in-oil-in-water (S/O/O/W) emulsification method. Methods G-CSF was loaded into dextran nanoparticles by freezing-induced phase separation, and then the G-CSF–loaded nanoparticles were encapsulated into sustained-release poly(lactic-co- glycolic acid) microspheres using S/O/O/W emulsification. The control microspheres were also prepared through W/O/W emulsification. The performance of the two microsphere formulations was investigated both in vitro and in vivo. Results The microspheres for the controlled release of G-CSF in a zero-order or near-zero-order pattern were provided for 2 weeks. The in vitro cumulative G-CSF release kept over 90% of its bioactivity, which was proved by a NFS-60 cell line growth assay. The microspheres of the control group fabricated by W/O/W emulsification maintained less then half of its bioactivity. The in vivo efficacy of microspheres made using the S/O/O/W method was higher than those using the W/O/W method. Conclusion These results suggested that the microspheres prepared by the S/O/O/W method had increased neutrophil activity compared to those prepared by W/O/W.
Decapitation and Dismemberment of the Corpse: A Matricide Case *

Abstract: Dismemberment of a corpse has always been viewed by society to be a more hideous crime than the homicide itself. In this study, we present a case of a 57‐year‐old woman who was decapitated and her right arm and both hands were dismembered. It was determined that the victim was murdered and dismembered by her 33‐year‐old daughter, who had been receiving treatment for schizophrenia for 15 years. On the victim’s head and back there were 71 incised and stab wounds in total. They were superficial, except the five stab wounds which were connected to the right chest cavity and which incapacitated the victim. Although there is not a regulation for the act of dismembering the corpse in the Turkish Penal Code, since this type of case is rare, the crime scene and the autopsy findings were evaluated together with other pertinent data available in the literature.
Uluslararası Öğrencilerin Yaşam Durumları: Kırklareli Ve Trakya Üniversiteleri Örneği

Universiteler dunya capinda uluslararasi kimlik kazanmaya ve ogrenci profilini cok uluslu hale getirmeye calismaktadir. Uluslararasi ogrenciler, universitelere cesitlilik kazandirmakla birlikte, bu ogrencilerin universite yasam deneyimleri, kazanimlarin yonunu, boyutunu ve surdurulebilir olma durumunu belirlemektedir. Bu arastirmada, uluslararasi statudeki ogrencilerin, Edirne ve Kirklareli’nde surdurdukleri ogrenimleri sosyal, akademik ve yasam baglamlari olmak uzere uc baslik altinda ele alinmistir. Calisma grubu, Trakya ve Kirklareli Universitelerinden toplam 38 uluslararasi ogrenciden olusmaktadir. Ogrencilere gorusme teknigi ile her bolumden (akademik, sosyal ve yasam baglamlari) ucer tane olmak uzere toplam dokuz soru yoneltilmistir. Elde edilen veriler icerik analizi ve betimsel analiz yoluyla cozumlenmistir. Calismada elde edilen sonuclar, uluslararasi ogrencilerin genel anlamda universite yasamlarindan, arkadas ve ogretim elemanlarindan memnun olduklarini, okuduklari universitenin akademik beklentilerini karsiladigini; ancak barinma ve ulasim icin herhangi bir yardim almadiklarini gostermektedir. Ayrica Turkce ogretiminin iyilestirilmesinin gerekliligi ortaya cikmistir. Elde edilen bulgular neticesinde uluslararasi ogrencilerin yasam, akademik ve sosyal baglamda halihazirda sahip olduklari memnuniyet duzeylerinin surdurulebilirligi adina bu ogrenciler icin merkezlerin kurulmasi ve bu merkezler araciligiyla oryantasyon calismalarinin yapilmasi saglanmalidir. Bunun yani sira ogrencilerin universiteye geldikleri anda barinma ve ulasim ihtiyaclarinin bu merkez araciligiyla saglanmasi onem tasimaktadir
Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome

Introduction Available data on plasma homocysteine level in patients with nephrotic syndrome (NS) are controversial with increased, decreased and unchanged values reported. Therefore, plasma homocysteine and serum B vitamins in Nigerian children with NS were assessed in this study Methods Fasting blood samples were analysed for plasma homocysteine, serum folate and B vitamins in 42 children with NS and 42 age and sex-matched healthy controls in this case control study. Data were compared between NS and control using t test and Chi square. Relationships were tested with regression analysis with p set at 0.05. Results Prevalence of hyperhomocysteinaemia, low folate and cyanocobalamin in NS was 57.1%, 14.3% and 9.5% respectively. The mean homocysteine level was significantly higher in NS than control (11.3±2.6µmol/L versus 5.5±2.3µmol/L). Also, NS had lower folate and cyanocobalamin than control: 9.1±3.9ng/mL versus 11.2±3.1ng/dL and 268.5±95.7pg/mL versus 316±117.2pg/mL respectively. Weak but significant correlation between homocysteine and serum albumin (r = 0.347), folate (r = -0.607) and vitamin B12 (r = -0.185) were found in the NS group. Significant relationship was also found between homocysteine and vitamin B12 (ß = -0.64, 95% CI = -1.20, -0.08) after controlling for folate and vitamin B6 levels. Conclusion Clinically important hyperhomocysteinaemia and low B vitamins occur in Nigerian children with nephrotic syndrome. This data suggest that potential usefulness of folate and vitamin B supplementation for reducing high homocysteine levels in nephrotic syndrome need to be further investigated