Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of aquatic exercises on primary dysmenorrhoea in nonathlete girls

Background: Primary dysmenorrhoea without any specific pelvic disease is one of the common complaints in women`s medicine. The general purpose of this research is to define the effects of 12-week aquatic exercises on nonathletic girls’ primary dysmenorrhoea. Materials and Methods: This quasi-experimental was conducted on 40 nonathletic girls aged 18-25 years. Data gathering tools were: Evaluation form of primary dysmenorrhoea and the pain evaluation tool based on the McGill standard pain questionnaire completed before and after the intervention in 3 months (first, second, and third run). Then, 20 subjects were assigned to aquatic exercise group and the other 20 to control group. The subjects in experimental group did aquatic exercise for three sessions a week for 60 minutes for 12 weeks between two menstruations. Kruskal — Wallis and one way analysis of variance (ANOVA) tests were used to analyze the data. Results: The results of this research indicated that severity and duration of pain decreased after 12 weeks of aquatic exercises. Comparison of the two groups showed a significant difference in pain intensity based on visual analogue scale (VAS) scale after these exercises (first, second, and third runs). Present pain intensity (PPI) scale after these exercises (second and third runs) showed a significant difference. Comparison of the two groups showed a significant difference in length of pain after these exercises (third run). Conclusions: Totally, the findings of the present study showed that 12-week regular aquatic exercises are effective on decrease of the severity of the symptoms of primary dysmenorrhoea.
Coping patterns as predictors of burnout: the function of control and escapist coping patterns

The paper attempts to bring concepts developed in cognitive approaches to stress and coping to a model which predicts burnout as a function of organizational demands and resources. Workers in a mental hospital (N = 177) provided information regarding coping patterns, burnout, and organizational commitment as well as various demands and resources in the work environment. A LISREL analysis confirmed that burnout is best considered a function of coping patterns as well as a function of organizational demands and resources. Control coping cognitions and actions were associated with decreased burnout, while escapist coping strategies were associated with increased burnout. The analysis indicated relationships of coping patterns with organizational commitment could be operating indirectly through the relationships of both coping patterns and commitment with the burnout. The paper discusses implications of these findings for interventions designed to alleviate or prevent burnout.
Classification and evolution of type II CRISPR-Cas systems

The CRISPR-Cas systems of archaeal and bacterial adaptive immunity are classified into three types that differ by the repertoires of CRISPR-associated (cas) genes, the organization of cas operons and the structure of repeats in the CRISPR arrays. The simplest among the CRISPR-Cas systems is type II in which the endonuclease activities required for the interference with foreign deoxyribonucleic acid (DNA) are concentrated in a single multidomain protein, Cas9, and are guided by a co-processed dual-tracrRNA:crRNA molecule. This compact enzymatic machinery and readily programmable site-specific DNA targeting make type II systems top candidates for a new generation of powerful tools for genomic engineering. Here we report an updated census of CRISPR-Cas systems in bacterial and archaeal genomes. Type II systems are the rarest, missing in archaea, and represented in ∼5% of bacterial genomes, with an over-representation among pathogens and commensals. Phylogenomic analysis suggests that at least three cas genes, cas1, cas2 and cas4, and the CRISPR repeats of the type II-B system were acquired via recombination with a type I CRISPR-Cas locus. Distant homologs of Cas9 were identified among proteins encoded by diverse transposons, suggesting that type II CRISPR-Cas evolved via recombination of mobile nuclease genes with type I loci.
Dose dependence of CTL precursor frequency induced by a DNA vaccine and correlation with protective immunity against influenza virus challenge.

Intramuscular injection of BALB/c mice with a DNA plasmid encoding nucleoprotein (NP) from influenza virus A/PR/8/34 (H1N1) provides cross-strain protection against lethal challenge with influenza virus A/HK/68 (H3N2). CTL specific for the H-2Kd-restricted epitope NP147-155 are present in these mice and are thought to play a role in the protection. To assess the effectiveness of NP DNA immunization in comparison with influenza virus infection in the induction of CTL responses, we monitored the frequency of CTL precursors (CTLp) in mice following i.m. injection with NP DNA or intranasal infection with influenza virus and showed that the CTLp frequency in NP DNA-immunized mice can reach levels found in mice that had been infected with influenza virus. We also measured the CTLp frequency, anti-NP Ab titers, and T cell proliferative responses in mice that were injected with titrated dosages of NP DNA and documented a correlation of the CTLp frequency and the Ab titers, but not proliferative responses, with the injection dose. Furthermore, we observed a positive correlation between the frequency of NP147-155 epitope-specific CTLp and the extent of protective immunity against cross-strain influenza challenge induced by NP DNA injection. Collectively, these results and our early observations from adoptive transfer experiments of in vitro activated lymphocytes from NP DNA-immunized mice suggest a protective function of NP-specific CTLp in mice against cross-strain influenza virus challenge.
Perceptions of the first family physicians to adopt advanced access in the province of Quebec, Canada

In Quebec, several primary care physicians have made the transition to the advanced access model to address the crisis of limited access to primary care. The objectives are to describe the implementation of the advanced access model, as perceived by the first family physicians; to analyze the factors influencing the implementation of its principles; and to document the physicians' perceptions of its effects on their practice, colleagues and patients. Qualitative methods were used to explore, through semi-structured interviews, the experiences of 21 family physicians who had made the transition to advanced access. Of the 21 physicians, 16 succeeded in adopting all five advanced access principles to varying degrees. Core implementation issues revolved around the dynamics of collaboration between physicians, nurses and other colleagues. Secretaries' functions, in particular, had to be expanded. Facilitating factors were mainly related to the physicians' leadership and the professional resources available in the organizations. Impediments related to resource availability and team functioning were also encountered. This is the first exploratory study to examine the factors influencing the adoption of the advanced access model conducted with early-adopter family physicians. The lessons drawn will inform discussions on scaling up to other settings experiencing the same problems. Copyright © 2016 John Wiley & Sons, Ltd.
Kinetics of oxygen uptake at the onset of exercise in boys and men.

The objective of this study was to compare the O2 uptake (VO2) kinetics at the onset of heavy exercise in boys and men. Nine boys, aged 9-12 yr, and 8 men, aged 19-27 yr, performed a continuous incremental cycling task to determine peak VO2 (VO2 peak). On 2 other days, subjects performed each day four cycling tasks at 80 rpm, each consisting of 2 min of unloaded cycling followed twice by cycling at 50% VO2 peak for 3.5 min, once by cycling at 100% VO2 peak for 2 min, and once by cycling at 130% VO2 peak for 75 s. O2 deficit was not significantly different between boys and men (respectively, 50% VO2 peak task: 6.6 +/- 11.1 vs. 5.5 +/- 7.3 ml . min-1 . kg-1; 100% VO2 peak task: 28.5 +/- 8.1 vs. 31.8 +/- 6.3 ml . min-1 . kg-1; and 130% VO2 peak task: 30.1 +/- 5.7 vs. 35.8 +/- 5.3 ml . min-1 . kg-1). To assess the kinetics, phase I was excluded from analysis. Phase II VO2 kinetics could be described in all cases by a monoexponential function. ANOVA revealed no differences in time constants between boys and men (respectively, 50% VO2 peak task: 22. 8 +/- 5.1 vs. 26.4 +/- 4.1 s; 100% VO2 peak task: 28.0 +/- 6.0 vs. 28.1 +/- 4.4 s; and 130% VO2 peak task: 19.8 +/- 4.1 vs. 20.7 +/- 5. 7 s). In conclusion, O2 deficit and fast-component VO2 on-transients are similar in boys and men, even at high exercise intensities, which is in contrast to the findings of other studies employing simpler methods of analysis. The previous interpretation that children rely less on nonoxidative energy pathways at the onset of heavy exercise is not supported by our findings.
Acute toxicity of potassium permanganate to fingerlings of the African catfish, Clarias gariepinus (Burchell, 1822)

Laboratory static bioassays were conducted to determine the 96-h LC50 and the lethal levels of concentrations of the aquaculture therapeutant, potassium permanganate (KMnO4) on fingerlings (mean weight, 6.24 ± 0.15 g and mean length, 4.25 ± 0.07 cm) of the African catfish, Clarias gariepinus. A total number of one hundred and eighty (180) fingerlings of mixed sex and brood stock were used for the toxicity bioassay. The 96-h median lethal concentration (LC50) value obtained for treatment of the fingerlings of the catfish C. gariepinus with potassium permanganate was 3.02 mg/L KMnO4 with lower and upper 95% confidence limits of 0.40 and 3.73 mg/L KMnO4, respectively. There was very strong and positive correlation between the variables (r = 0.96) with 93% (r2) association. Toxicity curve revealed 11.20 mg/L KMnO4 at 8.20 h as the threshold value for the 96 h assay of potassium permanganate on fingerlings of C. gariepinus. The 96 h LT50for 10, 8 and 6 mg/L KMnO4 to the test fish were also determined to be 10.40, 11.30 and 17.80 h, respectively. Varying behavioural patterns were observed in the fish, which included erratic swimming, loss of reflexes, total loss of equilibrium, paleness of skin and gasping for air. The value of water quality parameters monitored during the exposure period did not differ significantly (P>0.05) within the various concentrations of the therapeutant (KMnO4) as well as with the control. However, pH and total alkalinity tended to increase with increasing concentration of the toxicant. Key words: Potassium permanganate, acute toxicity, LC50, LT50, behaviour,Clarias gariepinus, Nigeria.
Political Participation and Civic Courage: The Negative Effect of Transparency on Making Small Campaign Contributions

AbstractThis study assesses whether public disclosure of campaign contributions affects citizens’ willingness to give money to candidates. In the American states, campaign finance laws require disclosure of private information for contributors at relatively low thresholds ranging from $1 to $300. The Internet has made it relatively easy to publicize such information in a way that changes the social context for political participation. Drawing on social influence theory, the analysis suggests that citizens are sensitive to divulging private information, especially those who are surrounded by people with different political views. Using experimental data from the 2011 Cooperative Congressional Election Studies, it demonstrates how individuals refrain from making small campaign contributions or reduce their donations to avoid disclosing their identities. The conclusion discusses the implications of transparency laws for political participation, especially for small donors.
Quantifiable Evidence, Reading Pedagogy, and Puppets

To advance the America Reads Initiative, the Clarice Smith Performing Arts Center (CSPAC) approved special puppet theatre projects to improve reading in local elementary schools. The following provides an overview of the America Reads Chal lenge and CSPAC's education projects, analyses the joint CSPAC/America Reads puppet project, and considers its efficacy. A consideration of debates between what might be called 'theatre education' (curriculum that develops the student as theatre artist) and 'educational theatre' (curriculum that utilises theatrical practices to develop 'other' skills), and a reconsideration of these very distinctions, based in pedagogical practices and cognitive theory, precedes direct analysis of the project. Systems for analysing educational theatre's efficacy are limited; material data of reading development cannot be linked causally to individual programmes. As an alternative to experiential knowledge, programme leaders adopted the pedagogical strategy 'rereading', which documents reading development in small groups. This author proposes that immediate, focused evaluation helps demonstrate quantitatively the local impact of an educational theatre project, while still maintaining the qualitative value of puppet theatre.
A Prevalence Study of Psychosocial Distress in Adolescents and Young Adults With Cancer

Background: Psychosocial distress is common among cancer patients. Significant associations between coping and social support with distress and quality of life in adult cancer patients have been identified before, but little is known about the interrelationships between distress, medical coping, and social support in adolescents and young adults (AYAs). Objective: The aims of this study are to investigate the prevalence of psychological distress in Chinese AYAs with cancer and examine the associations among distress, anxiety and depression, medical coping, and social support in the same population. Methods: A total of 610 AYA patients were recruited for this study; 551 patients completed the Chinese version of the National Comprehensive Cancer Network Distress Thermometer (DT), the Hospital Anxiety and Depression Scale, the Medical Coping Modes Questionnaire, and the Social Support Rating Scale. Results: The prevalence of psychological distress was 89.1% in Chinese AYAs with cancer. The DT scores were the highest in the 21- to 25-year-old patients; the DT scores were positively correlated with anxiety and depression (P < .01) but negatively correlated with medical coping and social support (P < .01). Conclusion: The prevalence of psychological distress in AYA cancer patients was higher than that in the general cancer population. Medical coping and social support can lower the prevalence of psychological distress in AYA cancer patients. Implications for Practice: Findings suggest the need for evidence-based intervention strategies to enhance medical coping and social support in AYA cancer patients. Nurses are crucial to implementing psychological interventions in AYA cancer patients.
Genetic Distances of Scallop (Chlamys farreri) Populations investigated by PCR Procedure

ABSTRACT The author performed PCR-based genetic platform to measure the hierarchical dendrogram of Euclidean genetic distances of Korean scallop populations (KSP), particularly for Chlamys farreri, which was further compared with those of the Chinese scallop populations (CSP), by employing the with specifically designed oligonucleotide primer sets. The scallop is economically and ecologically very important bivalves in South Korea. Relatively, individuals of KSP population were fairly distantly related to that of CSP population, as shown in the hierarchical dendrogram of Euclidean genetic distances. Comparatively, individuals of KSP population were fairly distantly related to that of CSP population. Thus analysis of genetic difference between scallop populations could provide important statistics for fishery and aquaculture. Overall the results showed specific and/or conserved genetic loci between scallop populations. Information on the genetic distance of the bivalve would be helpful to understand scallop expansion or conservation in the coastal regions of South Korea. Specific markers developed by the author will be useful for the analysis of scallop population genetics and distribution in coastal region.
Explaining Variations in Co-worker Assistance in Organizations

In an age of flattened hierarchies and networked organizations, lateral processes in organizations take on added significance. Co-worker assistance refers to a key aspect of lateral relations: workers' helping behaviour in relation to their immediate colleagues. Using data from a Dutch survey of public sector and related service employees, we develop and test a model of co-worker assistance. We argue that reciprocity facilitates management-induced co-worker assistance and that this depends on the extent of workers' organizational commitment. This in turn is influenced by the manner in which management exercises control over employees. We find evidence for organizational commitment acting as a partial mediator between co-worker assistance and bureaucratic control, co-worker control, and facilitative supervision respectively. Group cohesion, forged by workers independent of management, has a strong direct effect on co-worker assistance and a particularly strong effect when interacting with co-worker control. We also find that co-worker control is more strongly related to co-worker assistance where tasks are more interdependent.
The Orientation to Life Questionnaire: Validation of a Measure to Assess Older Adults’ Sense of Coherence

Increasingly, the literature suggests that the sense of coherence (SOC) positively influences well-being in later life. This study reports the assessment of the following psychometric properties: distributional properties, construct, criterion and external-related validities, and reliability of the Orientation to Life Questionnaire (OtLQ) in an cross-national population of older adults. We recruited 1291 community-dwelling older adults aged between 75–102 years (M = 83.9; SD = 6.68). Convenience sampling was used to gather questionnaire data. The construct validity was asserted by confirmatory factor analysis and convergent and discriminant validity. Moreover, criterion and external-related validities, as well as distributional properties and reliability, were also tested. Data gathered with the 29-items OtLQ scale showed overall good psychometric properties in terms of distributional properties, construct, criterion, and external-related validities, as well as reliability. Three factors were validated for the OtLQ scale: (a) comprehensibility; (b) manageability; and (c) meaningfulness. We validated the three-factor OtLQ scale, which produced valid and reliable data for a cross-national sample with older adults. Hence, it is an adequate instrument for assessing sense of coherence among older people in health care practice and program development contexts.
A Second Leukotriene B4 Receptor, Blt2

Leukotriene B4 (LTB4) is a potent chemoattractant and activator of both granulocytes and macrophages. The actions of LTB4 appear to be mediated by a specific G protein–coupled receptor (GPCR) BLT1, originally termed BLT (Yokomizo, T., T. Izumi, K. Chang, Y. Takuwa, and T. Shimizu. 1997. Nature. 387:620–624). Here, we report the molecular cloning of a novel GPCR for LTB4, designated BLT2, which binds LTB4 with a Kd value of 23 nM compared with 1.1 nM for BLT1, but still efficiently transduces intracellular signaling. BLT2 is highly homologous to BLT1, with an amino acid identity of 45.2%, and its open reading frame is located in the promoter region of the BLT1 gene. BLT2 is expressed ubiquitously, in contrast to BLT1, which is expressed predominantly in leukocytes. Chinese hamster ovary cells expressing BLT2 exhibit LTB4-induced chemotaxis, calcium mobilization, and pertussis toxin–insensitive inhibition of adenylyl cyclase. Several BLT1 antagonists, including U 75302, failed to inhibit LTB4 binding to BLT2. Thus, BLT2 is a pharmacologically distinct receptor for LTB4, and may mediate cellular functions in tissues other than leukocytes. BLT2 provides a novel target for antiinflammatory therapy and promises to expand our knowledge of LTB4 function. The location of the gene suggests shared transcriptional regulation of these two receptors.
Estimating Deterministic Trends in the Presence of Serially Correlated Errors

Abstract This paper studies the problems of estimation and inference in the linear trend model yt = α + βt + ut, where ut follows an autoregressive process with largest root ρ and β is the parameter of interest. We contrast asymptotic results for the cases | ρ | < 1 and ρ = 1 and argue that the most useful asymptotic approximations obtain from modeling ρ as local to unity. Asymptotic distributions are derived for the OLS, first-difference, infeasible GLS, and three feasible GLS estimators. These distributions depend on the local-to-unity parameter and a parameter that governs the variance of the initial error term κ. The feasible Cochrane–Orcutt estimator has poor properties, and the feasible Prais–Winsten estimator is the preferred estimator unless the researcher has sharp a priori knowledge about ρ and κ. The paper develops methods for constructing confidence intervals for β that account for uncertainty in ρ and κ. We use these results to estimate growth rates for real per-capita GDP in 128 countries.
The Fluff Test: A simple task to assess body representation neglect

In clinical settings, relatively little attention has been paid to the personal domain in neglect syndrome. This is in contrast to the important role that this aspect can play in rehabilitation training for patients who show neglect syndrome. We propose a simple task, the Fluff Test, which consists of an own body exploration with one's eyes closed. Analyses of 27 brain-damaged patients, 11 left braindamaged patients, and a group of 38 control subjects provide evidence that the Fluff Test can be used to assess deficits of body representation in neglect syndrome. This task has high test-150;retest reliability and is intended to compensate for the lack of measures evaluating patients' defective processing of one side of the body.
Rehabilitation with Brain-Computer Interface Systems

BCI systems let users convert thoughts into actions that do not involve voluntary muscle movement. The systems offer a new means of communication for those with paralysis or severe neuromuscular disorders. BCI technology is a relatively new, fast-growing field of research and applications with the potential to improve the quality of life in severely disabled people. To date, several BCI prototypes exist, but most work only in a laboratory environment. Before a BCI can be used for communication and control at home, research must solve several problems. An important next step is to establish protocols for easily setting up and using BCI systems in a practical environment. Many features, such as electrode positions and frequency components, must be automatically selectable for particular motor imagery. The system must use the fewest number of recording electrodes possible, striving for the optimal single EEG channel. Finally, training time must decrease, perhaps through game-like feedback and automatic detection of artifacts, such as uncontrolled muscle activity. With these improvements, which are on the horizon, we expect to see practical BCI systems for a wide range of users and applications.