Miracle-dz/UniFAR-FTUs huggingface dataset:
TRANSURETHRAL RESECTION OF THE PROSTATE

4 6 4 J O U R N A L C O M P I L A T I O N © 2 0 0 7 B J U I N T E R N A T I O N A L | 9 9 , 4 6 4 – 4 6 6 | doi:10.1111/j.1464-410X.2007. 06746.x and almost half of patients were aged > 65 years. Poor renal function has been a contraindication for platinum-based combination chemotherapy and thus these patients were obviously not included. (iv) There is no information on toxicity. How high is the price to pay? How much is lost in terms of quality of life and toxicity? The toxicity data were reported in the separate trials, e.g. “There was no unexpected morbidity and no mortality related to chemotherapy administration” in our second trial. Qualityof-life issues were not commonly analysed in trials at that time. (v) Are the results with single-agent cisplatin relevant, as combined therapy is superior and considered as standard; I agree that the latter is standard, but as single-agent administration had been evaluated in several trials it was of interest to also show these results. (iv) Newer chemotherapeutic agents are not included; I do not understand how they could be evaluated when these drugs were not available when the trials began.
Traversing the Web: mobility heuristics for visually impaired surfers

Movement, or mobility, is a key to the accessibility, design, and usability of many Web sites. While some peripheral mobility issues have been addressed few have centered on the mobility problems of visually impaired users. We use our past work to address these issues and derive mobility heuristics from mobility models, use these heuristics to place mobility objects within a Web page, and describe the construction of a prototype mobility instrument, in the form of a Netscape plug-in, to process these objects. Our past work extends the notion of movement to include environment, feedback and the purpose of the current travel task. Specifically, we likened web use to travelling in a virtual space, compared it to travelling in a physical space, and introduced the idea of mobility - the ease of travel - as opposed to travel opportunity.
Lymph Node Yield in Therapeutic Neck Dissection: Impact of Dissection Levels and Prior Radiotherapy

Objective: Lymph node yield in therapeutic neck dissection is clinically significant and incompletely studied. We quantified node yield based on extent of neck dissection and presence of preoperative radiation. We also evaluated factors affecting incidence of extracapsular spread (ECS). Methods: Retrospective review of 499 patients undergoing therapeutic neck dissection; 414 patients met inclusion criteria and were divided into 2 groups: neck dissection alone or before radiation (surgery first: 280 patients; 385 dissections) and primary radiation before surgery (radiation first: 134 patients; 157 dissections). Node yield relative to levels dissected and incidence of ECS were examined. Results: Dissection-specific node yield was greater in the surgery first group for dissection of levels I-V (31.1 ± 16.7 vs 24.0 ± 14.7, P < .001) and levels II-V (26.7 ± 14.4 vs 21.1 ± 10.7). Extracapsular spread incidence was 32.1% (98/305) in the surgery first group and 15.4% (23/149) in the radiation first group (P < .001). Conclusion: This study clarifies anticipated node yield based on number of levels dissected and presence of preoperative radiation. Node yield and incidence of ECS are lower in patients undergoing preoperative radiation.
An unexpected RNA distal interaction mode found in an essential region of the hepatitis C virus genome

Abstract The 3’X tail is a functionally essential 98-nt sequence located at the 3′-end of the hepatitis C virus (HCV) RNA genome. The domain contains two absolutely conserved dimer linkage sequence (DLS) and k nucleotide segments involved in viral RNA dimerization and in a distal base-pairing interaction with stem-loop 5BSL3.2, respectively. We have previously shown that domain 3’X forms an elongated structure comprising two coaxially stacked SL1’ and SL2’ stem-loops. This conformation favors RNA dimerization by exposing a palindromic DLS segment in an apical loop, but buries in the upper stem of hairpin SL2’ the k nucleotides involved in the distal contact with 5BSL3.2. Using nuclear magnetic resonance spectroscopy and gel electrophoresis experiments, here we show that the establishment of the complex between domain 3’X and stem-loop 5BSL3.2 only requires a rearrangement of the nucleotides forming the upper region of subdomain SL2’. The results indicate that the interaction does not occur through a canonical kissing loop mechanism involving the unpaired nucleotides of two terminal loops, but rather involves a base-paired stem and an apical loop and may result in a kissing three-way junction. On the basis of this information we suggest how the 3’X tail switches between monomer, homodimer and heterodimer states to regulate the HCV viral cycle.
Contagion in Mass Killings and School Shootings

Background Several past studies have found that media reports of suicides and homicides appear to subsequently increase the incidence of similar events in the community, apparently due to the coverage planting the seeds of ideation in at-risk individuals to commit similar acts. Methods Here we explore whether or not contagion is evident in more high-profile incidents, such as school shootings and mass killings (incidents with four or more people killed). We fit a contagion model to recent data sets related to such incidents in the US, with terms that take into account the fact that a school shooting or mass murder may temporarily increase the probability of a similar event in the immediate future, by assuming an exponential decay in contagiousness after an event. Conclusions We find significant evidence that mass killings involving firearms are incented by similar events in the immediate past. On average, this temporary increase in probability lasts 13 days, and each incident incites at least 0.30 new incidents (p = 0.0015). We also find significant evidence of contagion in school shootings, for which an incident is contagious for an average of 13 days, and incites an average of at least 0.22 new incidents (p = 0.0001). All p-values are assessed based on a likelihood ratio test comparing the likelihood of a contagion model to that of a null model with no contagion. On average, mass killings involving firearms occur approximately every two weeks in the US, while school shootings occur on average monthly. We find that state prevalence of firearm ownership is significantly associated with the state incidence of mass killings with firearms, school shootings, and mass shootings.
Parsing Tweets into Universal Dependencies

We study the problem of analyzing tweets with universal dependencies (UD). We extend the UD guidelines to cover special constructions in tweets that affect tokenization, part-of-speech tagging, and labeled dependencies. Using the extended guidelines, we create a new tweet treebank for English (Tweebank v2) that is four times larger than the (unlabeled) Tweebank v1 introduced by Kong et al. (2014). We characterize the disagreements between our annotators and show that it is challenging to deliver consistent annotation due to ambiguity in understanding and explaining tweets. Nonetheless, using the new treebank, we build a pipeline system to parse raw tweets into UD. To overcome the annotation noise without sacrificing computational efficiency, we propose a new method to distill an ensemble of 20 transition-based parsers into a single one. Our parser achieves an improvement of 2.2 in LAS over the un-ensembled baseline and outperforms parsers that are state-of-the-art on other treebanks in both accuracy and speed.
Evaluation of the added value of 1H-magnetic resonance spectroscopy for the diagnosis of pediatric brain lesions in clinical practice

Abstract Background Magnetic resonance spectroscopy (MRS) aids noninvasive diagnosis of pediatric brain tumors, but use in clinical practice is not well documented. We aimed to review clinical use of MRS, establish added value in noninvasive diagnosis, and investigate potential impact on patient care. Methods Sixty-nine children with lesions imaged using MRS and reviewed by the tumor board from 2014 to 2016 met inclusion criteria. Contemporaneous MRI diagnosis, spectroscopy analysis, histopathology, and clinical information were reviewed. Final diagnosis was agreed on by the tumor board at study end. Results Five cases were excluded for lack of documented MRI diagnosis. The principal MRI diagnosis by pediatric radiologists was correct in 59%, increasing to 73% with addition of MRS. Of the 73%, 19.1% (95% CI, 9.1%-33.3%) were incorrectly diagnosed with MRI alone. MRS led to a significant improvement in correct diagnosis over all tumor types (P = .012). Of diagnoses correctly made with MRI, confidence increased by 37% when adding MRS, with no patients incorrectly re-diagnosed. Indolent lesions were diagnosed noninvasively in 85% of cases, with MRS a major contributor to 91% of these diagnoses. Of all patients, 39% were managed without histopathological diagnosis. MRS contributed to diagnosis in 68% of this group, modifying it in 12%. MRS influenced management in 33% of cases, mainly through avoiding and guiding biopsy and aiding tumor characterization. Conclusion MRS can improve accuracy and confidence in noninvasive diagnosis of pediatric brain lesions in clinical practice. There is potential to improve outcomes through avoiding biopsy of indolent lesions, aiding tumor characterization, and facilitating earlier family discussions and treatment planning.
OpenStreetCab: Exploiting Taxi Mobility Patterns in New York City to Reduce Commuter Costs

The rise of Uber as the global alternative taxi operator has attracted a lot of interest recently. Aside from the media headlines which discuss the new phenomenon, e.g. on how it has disrupted the traditional transportation industry, policy makers, economists, citizens and scientists have engaged in a discussion that is centred around the means to integrate the new generation of the sharing economy services in urban ecosystems. In this work, we aim to shed new light on the discussion, by taking advantage of a publicly available longitudinal dataset that describes the mobility of yellow taxis in New York City. In addition to movement, this data contains information on the fares paid by the taxi customers for each trip. As a result we are given the opportunity to provide a first head to head comparison between the iconic yellow taxi and its modern competitor, Uber, in one of the world's largest metropolitan centres. We identify situations when Uber X, the cheapest version of the Uber taxi service, tends to be more expensive than yellow taxis for the same journey. We also demonstrate how Uber's economic model effectively takes advantage of well known patterns in human movement. Finally, we take our analysis a step further by proposing a new mobile application that compares taxi prices in the city to facilitate traveller's taxi choices, hoping to ultimately to lead to a reduction of commuter costs. Our study provides a case on how big datasets that become public can improve urban services for consumers by offering the opportunity for transparency in economic sectors that lack up to date regulations.
Proximal Junctional Kyphosis

Proximal junctional kyphosis (PJK) is a common complication following adult spinal deformity surgery. It is defined by two criteria: a proximal junctional sagittal Cobb angle (1) ≥10° and (2) at least 10° greater than the preoperative measurement. PJK is multifactorial in origin and likely stems from surgical, radiographic, and patient-related risk factors. The diagnosis of PJK represents a broad spectrum of disease ranging from asymptomatic patients with recurrence of deformity to those presenting with increased pain, functional deficit, and, in the most severe cases, neurologic deficits. Recent studies have demonstrated increased pain levels in select patients with PJK. In keeping with the broad spectrum of the disease, classification schemes are needed to better describe and stratify the severity of PJK. The most severe form is proximal junctional failure. A consensus on a uniform definition of proximal junctional failure is needed to allow for more systematic study of this phenomenon.
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.

BACKGROUND & AIMS Some studies have indicated that dietary cholesterol has a role in the progression of liver fibrosis. We investigated the mechanisms by which dietary cholesterol might contribute to hepatic fibrogenesis. METHODS C57BL/6 mice were fed a high-cholesterol diet or a control diet for 4 weeks; liver fibrosis then was induced by bile-duct ligation or carbon tetrachloride administration. Hepatic stellate cells (HSCs) were isolated from mice fed high-cholesterol diets or from Niemann-Pick type C1-deficient mice, which accumulate intracellular free cholesterol. RESULTS After bile-duct ligation or carbon tetrachloride administration, mice fed high-cholesterol diets had significant increases in liver fibrosis and activation of HSCs compared with mice fed control diets. There were no significant differences in the degree of hepatocellular injury or liver inflammation, including hepatocyte apoptosis or Kupffer cell activation, between mice fed high-cholesterol or control diets. Levels of free cholesterol were much higher in HSCs from mice fed high-cholesterol diets than those fed control diets. In cultured HSCs, accumulation of free cholesterol in HSCs increased levels of Toll-like receptor 4 (TLR4), leading to down-regulation of bone morphogenetic protein and activin membrane-bound inhibitor (a pseudoreceptor for transforming growth factor [TGF]β); the HSCs became sensitized to TGFβ-induced activation. Liver fibrosis was not aggravated by the high-cholesterol diet in C3H/HeJ mice, which express a mutant form of TLR4; HSCs that express mutant TLR4 were not activated by accumulation of free cholesterol. CONCLUSIONS Dietary cholesterol aggravates liver fibrosis because free cholesterol accumulates in HSCs, leading to increased TLR4 signaling, down-regulation of bone morphogenetic protein and activin membrane-bound inhibitor, and sensitization of HSC to TGFβ. This pathway might be targeted by antifibrotic therapies.
Psychosocial and behavioral correlates of anxiety symptoms in a sample of HIV-positive, methamphetamine-using men who have sex with men

Abstract Studies show high rates of psychiatric symptoms among methamphetamine users; however, little information exists regarding methamphetamine use and anxiety. This study investigated psychosocial and behavioral correlates of anxiety symptoms in a sample of 245 HIV-positive men having sex with men (MSM) who were enrolled in a sexual risk-reduction intervention. In a multiple regression analysis, anxiety symptoms were associated with homelessness, recent experience of HIV symptoms, injection drug use, lifetime sexual abuse, engaging in risky sexual behaviors, and seeking out partners at risky sexual venues when “high” on methamphetamine. These findings can be used to inform and refine sexual risk-reduction interventions and substance-use treatment programs for HIV-positive methamphetamine-using MSM.
Spatial Pattern of Land Use Change and Its Driving Force in Jiangsu Province

Scientific interpretation of the mechanism of land use change is important for government planning and management activities. This study analyzes the land use change in Jiangsu Province using three land use maps of 2000, 2005 and 2008. The study results show that there was a significant change in land use. The change was mainly characterized by a continuous built-up land expansion primarily at the expense of cropland loss, and the trend became increasingly rapid. There was an obvious regional difference, as most of the cropland loss or built-up land expansion took place in southern Jiangsu, where the rate of built-up land expansion was faster than in central and northern Jiangsu. Meanwhile, the spatial pattern changed remarkably; in general, the number of patches (NumP) showed a declining trend, and the mean patch size (MPS) and patch size standard deviation (PSSD) displayed increase trends. Furthermore, the relative importance of selected driven factors was identified by principal component analysis (PCA) and general linear model (GLM). The results showed that not only the relative importance of a specific driving factor may vary, but the driven factors may as well. The most important driven factor changed from urban population (UP), secondary gross domestic product (SGDP) and gross domestic product (GDP) during 2000–2005 to resident population (RP), population density (POD) and UP during 2005–2008, and the deviance explained (DE) decreased from 91.60% to 81.04%. Policies also had significant impacts on land use change, which can be divided into direct and indirect impacts. Development policies usually had indirect impacts, particularly economic development policies, which promote the economic development to cause land use change, while land management policies had direct impacts. We suggest that the government should think comprehensively and cautiously when proposing a new development strategy or plan.
Oxydative phosphorylation in sciatic nerve myelin and its impairment in a model of dysmyelinating peripheral neuropathy

Myelin sheath is the proteolipid membrane wrapping the axons of CNS and PNS. We have shown data suggesting that CNS myelin conducts oxidative phosphorylation (OXPHOS), challenging its role in limiting the axonal energy expenditure. Here, we focused on PNS myelin. Samples were: (i) isolated myelin vesicles (IMV) from sciatic nerves, (ii) mitochondria from primary Schwann cell cultures, and (iii) sciatic nerve sections, from wild type or Charcot‐Marie‐Tooth type 1A (CMT1A) rats. The latter used as a model of dys‐demyelination. O2 consumption and activity of OXPHOS proteins from wild type (Wt) or CMT1A sciatic nerves showed some differences. In particular, O2 consumption by IMV from Wt and CMT1A 1‐month‐old rats was comparable, while it was severely impaired in IMV from adult affected animals. Mitochondria extracted from CMT1A Schwann cell did not show any dysfunction. Transmission electron microscopy studies demonstrated an increased mitochondrial density in dys‐demyelinated axons, as to compensate for the loss of respiration by myelin. Confocal immunohistochemistry showed the expression of OXPHOS proteins in the myelin sheath, both in Wt and dys‐demyelinated nerves. These revealed an abnormal morphology. Taken together these results support the idea that also PNS myelin conducts OXPHOS to sustain axonal function.
Rethinking Belady's Algorithm to Accommodate Prefetching

This paper shows that in the presence of data prefetchers, cache replacement policies are faced with a large unexplored design space. In particular, we observe that while Belady's MIN algorithm minimizes the total number of cache misses—including those for prefetched lines—it does not minimize the number of demand misses. To address this shortcoming, we introduce Demand-MIN, a variant of Belady's algorithm that minimizes the number of demand misses at the cost of increased prefetcher traffic. Together, MIN and Demand-MIN define the boundaries of an important design space, with many intermediate points lying between them. To reason about this design space, we introduce a simple conceptual framework, which we use to define a new cache replacement policy called Harmony. Our empirical evaluation shows that for a mix of SPEC 2006 benchmarks running on a 4-core system with a stride prefetcher, Harmony improves IPC by 7.7% over an LRU baseline, compared to 3.7% for the previous state-of-the-art. On an 8-core system, Harmony improves IPC by 9.4% compared to 4.4% for the previous state-of-the-art.
Aging and Decision Making: Driving-Related Problem Solving

We examined age-related effects on decision making in a task environment familiar to most younger and older adults. Participants made route-selection decisions in real time. Participants received information about traffic density and expected speed limits of main and alternative routes, from which they determined the optimality of their present route versus alternative routes. The experiment evaluated the effects of information type, amount of congestion, alternative route speed limit, and age on speed and quality of decision making. Measures of optimal route selection revealed main effects of alternative route speed limit, congestion level, and message type, but there was not a main effect of age, and age did not interact with any variable. In terms of decision speed (but not quality of decision making), older participants were slower, and age interacted with alternative route speed and with message type. The data are interpreted in relation to previous data examining everyday problem solving and aging.
Low-Complexity SIC Detection Algorithms for Multiple-Input Multiple-Output Systems

A new design for successive interference cancellation (SIC) detection for multiple-input multiple-output systems is introduced, and it is developed on the basis of the method of normal equations commonly used to solve the linear least squares problem. On the basis of this design, optimal-ordered and suboptimal-ordered SIC detection algorithms are derived. It is shown that the proposed optimal-ordered SIC detection algorithm offers a complexity reduction ratio of 1.11-1.25 compared to the fastest known optimal-ordered SIC detection algorithm for intermediate and large numbers of antennas and in terms of the average complexity. On the other hand, the proposed suboptimal-ordered SIC detection algorithm requires a lower complexity than the proposed optimal-ordered one and provides a bit-error-rate performance close to that of the optimal-ordered one and better than those of the other suboptimal-ordered SIC detection algorithms.
Very Deep Convolutional Networks for Text Classification

The dominant approach for many NLP tasks are recurrent neural networks, in particular LSTMs, and convolutional neural networks. However, these architectures are rather shallow in comparison to the deep convolutional networks which have pushed the state-of-the-art in computer vision. We present a new architecture (VDCNN) for text processing which operates directly at the character level and uses only small convolutions and pooling operations. We are able to show that the performance of this model increases with the depth: using up to 29 convolutional layers, we report improvements over the state-of-the-art on several public text classification tasks. To the best of our knowledge, this is the first time that very deep convolutional nets have been applied to text processing.