Miracle-dz/UniFAR-FTUs huggingface dataset:
Unifying Theories of Psychedelic Drug Effects

How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of psychedelic-assisted therapies? Efforts to understand psychedelic phenomena date back more than a century in Western science. In this article I review theories of psychedelic drug effects and highlight key concepts which have endured over the last 125 years of psychedelic science. First, I describe the subjective phenomenology of acute psychedelic effects using the best available data. Next, I review late 19th-century and early 20th-century theories—model psychoses theory, filtration theory, and psychoanalytic theory—and highlight their shared features. I then briefly review recent findings on the neuropharmacology and neurophysiology of psychedelic drugs in humans. Finally, I describe recent theories of psychedelic drug effects which leverage 21st-century cognitive neuroscience frameworks—entropic brain theory, integrated information theory, and predictive processing—and point out key shared features that link back to earlier theories. I identify an abstract principle which cuts across many theories past and present: psychedelic drugs perturb universal brain processes that normally serve to constrain neural systems central to perception, emotion, cognition, and sense of self. I conclude that making an explicit effort to investigate the principles and mechanisms of psychedelic drug effects is a uniquely powerful way to iteratively develop and test unifying theories of brain function.
Prognostic Significance of Plasma High‐Sensitivity C‐Reactive Protein in Patients With Hypertrophic Cardiomyopathy

Background Elevated high‐sensitivity C‐reactive protein (hsCRP) has been associated with increased risks of adverse outcomes of various cardiovascular diseases. The relationship between hsCRP and the prognosis of hypertrophic cardiomyopathy remains to be evaluated. Methods and Results The study used an observational cohort methodology. A total of 490 patients were enrolled in the Fuwai Hospital from 2001 to 2011 and were followed for 3.7±2.0 years. According to the risk category of hsCRP, subjects in the high hsCRP group (>3.0 mg/L) had a higher risk of developing adverse events than the low hsCRP group (<1.0 mg/L): cardiovascular death (adjusted hazard ratios[HR] 5.41, 95% CI 1.96–14.93, P=0.001), all‐cause mortality (adjusted HR 4.78, 95% CI 1.99–11.47, P<0.001), sudden cardiac death (adjusted HR 11.29, 95% CI 1.38–92.20, P=0.024), and heart failure–related death (adjusted HR 4.38, 95% CI 1.15–16.60, P=0.030). Similarly, the continuous variable of hsCRP was also an independent predictor for adverse outcomes: cardiovascular death (adjusted HR 1.15, 95% CI 1.06–1.25, P=0.001), all‐cause mortality (adjusted HR 1.17, 95% CI 1.09–1.26, P<0.001), sudden cardiac death (adjusted HR 1.20, 95% CI 1.06–1.36, P=0.003), and heart failure–related death (adjusted HR 1.15, 95% CI 1.02–1.30, P=0.020). Conclusions Our results indicate that elevated plasma hsCRP is associated with increased risk for adverse outcomes in patients with hypertrophic cardiomyopathy.
Valid statistical inference methods for a case–control study with missing data

The main objective of this paper is to derive the valid sampling distribution of the observed counts in a case–control study with missing data under the assumption of missing at random by employing the conditional sampling method and the mechanism augmentation method. The proposed sampling distribution, called the case–control sampling distribution, can be used to calculate the standard errors of the maximum likelihood estimates of parameters via the Fisher information matrix and to generate independent samples for constructing small-sample bootstrap confidence intervals. Theoretical comparisons of the new case–control sampling distribution with two existing sampling distributions exhibit a large difference. Simulations are conducted to investigate the influence of the three different sampling distributions on statistical inferences. One finding is that the conclusion by the Wald test for testing independency under the two existing sampling distributions could be completely different (even contradictory) from the Wald test for testing the equality of the success probabilities in control/case groups under the proposed distribution. A real cervical cancer data set is used to illustrate the proposed statistical methods.
Drug resistance and R factors among enterobacteria isolated from eggs.

Abstract The incidence of Escherichia coli and Salmonellae on eggs from 20 chicken and 20 turkey flocks in Ohio was determined. Cultures isolated from 734 chicken and 412 turkey eggs were tested for drug resistance to nine antimicrobial agents by a standardized single disc method. The isolates resistant to chlortetracycline and/or dihydrostreptomycin were tested for the ability to transfer drug resistance to E. coli K-12NA in vitro. E. coli was isolated from 294 (25.5%) of the chicken and turkey eggs examined during this study. Only four cultures of Salmonella (three species) were isolated and only one of these was drug-resistant (to dihydrostreptomycin only). This single resistant culture did have R factor. Of the 294 isolates of E. coli, 180 (61.2%) were found to be resistant to one or more antimicrobial agents. Among the resistant isolates, 82.8 percent were multiple resistant and 17.2 percent were resistant to only one drug. Over half (55.4%) of the “resistant” E. coli isolates transferred all or a part of their resistance patterns to the drug-sensitive recipient strain. A higher percentage of E. coli strains were resistant to dihydrostreptomycin (49.6%) and to the tetracyclines (46.6%) than to any other antimicrobial used in this study. The drug resistance patterns of the R factor-carrying E. coli cultures isolated from the four flocks from which Salmonellae were also isolated were not found in the Salmonella species.
Sensitivity of chickpea and faba bean to root-zone hypoxia, elevated ethylene, and carbon dioxide.

During soil waterlogging, plants experience O2 deficits, elevated ethylene, and high CO2 in the root-zone. The effects on chickpea (Cicer arietinum L.) and faba bean (Vicia faba L.) of ethylene (2 μL L-1 ), CO2 (2-20% v/v) or deoxygenated stagnant solution were evaluated. Ethylene and high CO2 reduced root growth of both species, but O2 deficiency had the most damaging effect and especially so for chickpea. Chickpea suffered root tip death when in deoxygenated stagnant solution. High CO2 inhibited root respiration and reduced growth, whereas sugars accumulated in root tips, of both species. Gas-filled porosity of the basal portion of the primary root of faba bean (23%, v/v) was greater than for chickpea (10%), and internal O2 movement was more prominent in faba bean when in an O2 -free medium. Ethylene treatment increased the porosity of roots. The damaging effects of low O2 , such as death of root tips, resulted in poor recovery of root growth upon reaeration. In conclusion, ethylene and high CO2 partially inhibited root extension in both species, but low O2 in deoxygenated stagnant solution had the most damaging effect, even causing death of root tips in chickpea, which was more sensitive to the low O2 condition than faba bean.
Adaptive Random Testing by Exclusion through Test Profile

One major objective of software testing is to reveal software failures such that program bugs can be removed. Random testing is a basic and simple software testing technique, but its failure-detection effectiveness is often controversial. Based on the common observation that program inputs causing software failures tend to cluster into contiguous regions, some researchers have proposed that an even spread of test cases should enhance the failure-detection effectiveness of random testing. Adaptive random testing refers to a family of algorithms to evenly spread random test cases based on various notions. Restricted random testing, an algorithm to implement adaptive random testing by the notion of exclusion, defines an exclusion region around each previously executed test case, and selects test cases only from outside all exclusion regions. Although having a high failure-detection effectiveness, restricted random testing has a very high computation overhead, and it rigidly discards all test cases inside any exclusion region, some of which may reveal software failures. In this paper, we propose a new method to implement adaptive random testing by exclusion, where test cases are simply selected based on a well-designed test profile. The new method has a low computation overhead and it does not omit any possible program inputs that can detect failures. Our experimental results show that the new method not only spreads test cases more evenly but also brings a higher failure-detection effectiveness than random testing.
Prevention of foot pad dermatitis in poults with methionine.

Abstract Poults fed diets containing isolated soybean protein or soybean meal developed a dermatitis on their foot pads. It could be prevented by the addition of methionine to the diet but was unrelated to the addition of sulfate or extra biotin. This disorder was observed more in White than Bronze poults.
Timing Matters in Hip Fracture Surgery: Patients Operated within 48 Hours Have Better Outcomes. A Meta-Analysis and Meta-Regression of over 190,000 Patients

Background To assess the relationship between surgical delay and mortality in elderly patients with hip fracture. Systematic review and meta-analysis of retrospective and prospective studies published from 1948 to 2011. Medline (from 1948), Embase (from 1974) and CINAHL (from 1982), and the Cochrane Library. Odds ratios (OR) and 95% confidence intervals for each study were extracted and pooled with a random effects model. Heterogeneity, publication bias, Bayesian analysis, and meta-regression analyses were done. Criteria for inclusion were retro- and prospective elderly population studies, patients with operated hip fractures, indication of timing of surgery and survival status. Methodology/Principal Findings There were 35 independent studies, with 191,873 participants and 34,448 deaths. The majority considered a cut-off between 24 and 48 hours. Early hip surgery was associated with a lower risk of death (pooled odds ratio (OR) 0.74, 95% confidence interval (CI) 0.67 to 0.81; P<0.000) and pressure sores (0.48, 95% CI 0.38 to 0.60; P<0.000). Meta-analysis of the adjusted prospective studies gave similar results. The Bayesian probability predicted that about 20% of future studies might find that early surgery is not beneficial for decreasing mortality. None of the confounders (e.g. age, sex, data source, baseline risk, cut-off points, study location, quality and year) explained the differences between studies. Conclusions/Significance Surgical delay is associated with a significant increase in the risk of death and pressure sores. Conservative timing strategies should be avoided. Orthopaedic surgery services should ensure the majority of patients are operated within one or two days.
Controlling Within-Field Sheep Movement Using Virtual Fencing

Simple Summary Virtual fencing has the potential to increase the implementation of spatial grazing management and targeted grazing without the use of conventional fencing. Current virtual fencing that uses an algorithm that is patented through CSIRO involves a collar that emits a warning audio when an animal approaches a set boundary. If the animal continues walking towards the boundary, an electric stimulus is applied. Using manually operated collars to implement a similar virtual fence, a small group of sheep were restricted from accessing a section of a small paddock. Sheep were successfully kept out of the excluded zone of the paddock. By the third day, the sheep were able to avoid receiving an electrical stimulus by turning away from the boundary when the warning audio was applied. When the sheep were allowed full access to the paddock again, then they were quick to use the once restricted area. Abstract Virtual fencing has the potential to greatly improve livestock movement, grazing efficiency, and land management by farmers; however, relatively little work has been done to test the potential of virtual fencing with sheep. Commercial dog training equipment, comprising of a collar and GPS hand-held unit were used to implement a virtual fence in a commercial setting. Six, 5–6 year-old Merino wethers, which were naïve to virtual fencing were GPS tracked for their use of a paddock (80 × 20 m) throughout the experiment. The virtual fence was effective at preventing a small group of sheep from entering the exclusion zone. The probability of a sheep receiving an electrical stimulus following an audio cue was low (19%), and declined over the testing period. It took an average of eight interactions with the fence for an association to be made between the audio and stimulus cue, with all of the animals responding to the audio alone by the third day. Following the removal of the virtual fence, sheep were willing to cross the previous location of the virtual fence after 30 min of being in the paddock. This is an important aspect in the implementation of virtual fencing as a grazing management tool and further enforces that the sheep in this study were able to associate the audio with the virtual fence and not the physical location itself.
Understanding Membership Inferences on Well-Generalized Learning Models

Membership Inference Attack (MIA) determines the presence of a record in a machine learning model's training data by querying the model. Prior work has shown that the attack is feasible when the model is overfitted to its training data or when the adversary controls the training algorithm. However, when the model is not overfitted and the adversary does not control the training algorithm, the threat is not well understood. In this paper, we report a study that discovers overfitting to be a sufficient but not a necessary condition for an MIA to succeed. More specifically, we demonstrate that even a well-generalized model contains vulnerable instances subject to a new generalized MIA (GMIA). In GMIA, we use novel techniques for selecting vulnerable instances and detecting their subtle influences ignored by overfitting metrics. Specifically, we successfully identify individual records with high precision in real-world datasets by querying black-box machine learning models. Further we show that a vulnerable record can even be indirectly attacked by querying other related records and existing generalization techniques are found to be less effective in protecting the vulnerable instances. Our findings sharpen the understanding of the fundamental cause of the problem: the unique influences the training instance may have on the model.
Studying the Effects of Task Notification Policies on Participation and Outcomes in On-the-go Crowdsourcing

Recent years have seen the growth of physical crowdsourcing systems (e.g., Uber; TaskRabbit) that motivate large numbers of people to provide new and improved physical tasking and delivery services on-demand. In these systems, opportunistically relying on people to make convenient contributions may lead to incomplete solutions, while directing people to do inconvenient tasks requires high incentives. To increase people's willingness to participate and reduce the need to incentivize participation, we study on-the-go crowdsourcing as an alternative approach that suggests tasks along people’s existing routes that are conveniently on their way. We explore as a first step in this paper the design of task notification policies that decide when, where, and to whom to suggest tasks. Situating our work in the context of practical problems such as package delivery and lost-and-found searches, we conducted controlled experiments that show how small changes in task notification policy can influence individual participation and actions in significant ways that in turn affect system outcomes. We discuss the implications of our findings on the design of future on-the-go crowdsourcing technologies and applications.
Wheat middlings as an alternative feedstuff for laying hens.

Three long-term experiments were conducted to evaluate the possibility of using wheat middlings (WM) for laying hens and to study the responses of six strains of commercial laying hens fed WM diet. In Experiment 1,320 layers maintained in floor pens were fed diets containing 45% WM with . 25 or . 75% salt, or 89% WM with . 25% or 1.5% salt. Salt supplementation did not show any beneficial effect on egg production. Hen-day egg production by hens fed the 45% WM diet was significantly higher for hens fed 45% WM than for those fed the 89% WM diet (79 versus 67.5%, 44-wk period). Feed, limestone, and water intakes were increased by the 89% WM diet. Yolk color, Haugh units, hen livability, and reproductive parameters were not different among the dietary treatments. In Experiments 2 and 3, laying hens from six commercial strains (four strains each experiment, 240 hens per strain) were maintained in laying cages in each year, and fed either a corn and soybean meal (CSM) or a 25% WM diet. Results show that neither diet nor strain had effects on hen-day egg production; however, egg weights from Strains A, C, and F were heavier than those from Strains B, D, and E. Feed intakes and feed utilizations were similar among the s trains. The 25% WM diet increased egg weight, feed intake, and feed utilization compared with the CSM diet. Livability of hens was 93.8 to 97.5% and was not affected by either strain or diet. It is concluded that commercial strains of laying hens can be fed diets containing 25 to 45% WM and still have normal hen-day egg production although feed utilization will be poorer.
Pain Management in Patients with Inflammatory Bowel Disease: Translational Approaches from Bench to Bedside

Abstract:Abdominal pain is a common symptom in patients with inflammatory bowel disease (IBD) that negatively affects quality of life and can lead to increased health-seeking behavior. Although abdominal pain has been traditionally attributed to inflammation, there is growing literature demonstrating the existence of functional abdominal pain in patients with IBD, of which there are a variety of potential causes. Thus, when approaching a patient with IBD who has abdominal pain, in addition to IBD-related complications (e.g., inflammation/stricture), it is important to screen for related contributors, including peripheral factors (visceral hypersensitivity, bacterial overgrowth, and bowel dysmotility) and centrally mediated neurobiological and psychosocial underpinnings. These central factors include psychological symptoms/diagnoses, sleep disturbance, and stress. Opioid-induced hyperalgesia (e.g., narcotic bowel syndrome) is also growing in recognition as a potential central source of abdominal pain. This review draws from clinical studies and animal models of colitis and abdominal pain to consider how knowledge of these potential etiologies can be used to individualize treatment of abdominal pain in patients with IBD, including consideration of potential novel treatment modalities for the future. Accurate assessment of the source(s) of pain in patients with IBD can help guide appropriate diagnostic workup and use of disease-modifying therapy.
4-Week consumption of anthocyanin-rich blood orange juice does not affect LDL-cholesterol or other biomarkers of CVD risk and glycaemia compared with standard orange juice: a randomised controlled trial

Abstract Elevated circulating cholesterol levels are a risk factor for CVD which is also associated with sub-optimal vascular function. There is emerging evidence that anthocyanins can cause beneficial cardio-protective effects by favourably modulating lipoprotein profiles. We compared the effects of blood orange juice which is rich in anthocyanins and blonde orange juice without anthocyanins on LDL-cholesterol and other biomarkers of CVD risk, vascular function and glycaemia. In all, forty-one participants (aged 25–84 years) with a waist circumference >94 cm (men) and >80 cm (women) completed a randomised, open label, two-arm cross-over trial. For 28 d participants ingested (i) 500 ml blood orange juice providing 50 mg anthocyanins/d and (ii) 500 ml blonde orange juice without anthocyanins. There was a minimum 3-week washout period between treatments. LDL-cholesterol and other biomarkers associated with CVD risk and glycaemia were assessed at the start and end of each treatment period. No significant differences were observed in total, HDL- and LDL-cholesterol, TAG, glucose, fructosamine, nitric oxide, C-reactive protein, aortic systolic blood pressure and diastolic blood pressure or carotid-femoral and brachial-ankle pulse wave velocity after 28 d ingestion of blood orange juice compared with standard orange juice. The lack of effect on LDL-cholesterol may be due to the modest concentration of anthocyanins in the blood orange juice.
Effect of high dietary copper on the ceca of chicks.

Including 120 to 250 mg. /kg. additional copper in practical broiler rations significantly affected the cecal appearance. The ceca were distended and the contents were darker in color and more pasty in consistency, compared to controls. Adding monensin sodium, gentian violet, or ferrous sulfate alone or in combination with copper to the ration did not significantly change the appearance of the ceca. Copper concentrations in the cecal contents reached levels above 5000 mg. /kg. , suggesting that the mechanism of action of copper in changing the appearance of the ceca may be related to an inhibition of normal fermentation that occurs in this part of the gastrointestinal tract. Sulfate, chloride and carbonate forms of copper all significantly changed cecal appearance, but the oxide did not, nor did a non-copper containing sulfate source. Macroscopic appearance of the gizzard lining and the proventriculus was also significantly changed by adding 240 mg. /kg. copper to the diet, and liver weight and lipid content of liver dry matter were significantly increased.
Pertuzumab Plus Chemotherapy for Platinum-Resistant Ovarian Cancer: Safety Run-in Results of the PENELOPE Trial

Objective In platinum-resistant ovarian cancer, adding pertuzumab to gemcitabine improved progression-free survival in the subgroup with low tumor HER3 messenger RNA expression. The 2-part PENELOPE trial (NCT01684878) is prospectively investigating pertuzumab plus chemotherapy in this population. Patients and Methods Part 1 evaluated pertuzumab plus either topotecan or paclitaxel. Patients with platinum-refractory or platinum-resistant recurrent ovarian, primary peritoneal, or fallopian tube cancer and low HER3 messenger RNA expression (concentration ratio ≤2.81 by central quantitative reverse transcriptase-polymerase chain reaction testing on Cobas z480) received intravenous pertuzumab (840 mg loading dose then 420 mg every 3 weeks) with the investigator’s choice of topotecan (1.25 mg/m2 days 1–5 every 3 weeks) or weekly paclitaxel (80 mg/m2) until disease progression or unacceptable toxicity. The primary objective was to assess safety and tolerability. Results Fifty patients were treated in part 1 (22 topotecan; 28 paclitaxel). In both cohorts, disease progression was the most common primary reason for discontinuing pertuzumab, and the most common all-grade adverse events (AEs) were fatigue/asthenia, anemia, and diarrhea. The most common grade ≥3 AEs were anemia (36%), neutropenia (27%), and fatigue/asthenia (18%) for topotecan, and peripheral sensory neuropathy (14%) and anemia (11%) for paclitaxel. Two patients receiving paclitaxel-pertuzumab died from AEs (abdominal infection; unexplained death). Median progression-free survival was 4.1 months (95% confidence interval, 1.9–6.1) with topotecan-pertuzumab and 4.2 months (95% confidence interval, 3.5–6.0) with paclitaxel-pertuzumab. Conclusions Based on part 1 tolerability, the Independent Data Monitoring Committee had no objection to PENELOPE proceeding to part 2, a double-blind randomized comparison of chemotherapy (topotecan, paclitaxel, or gemcitabine) plus pertuzumab or placebo.