Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving vibrotactile pattern identification for mobile devices using perceptually transparent rendering

At present, vibration feedback is widely used to improve the limited user interface of a mobile device. Despite recent advances of miniature actuator technology, a vibration motor is still a dominant actuator for commercial mobile devices. In this paper, we present a new vibration rendering method which can enhance the identification of mobile device vibrations produced by a vibration motor. Whereas the traditional method separates vibrations in voltage applied to the motor, we partition vibrations in their perceived intensity using perceptually transparent rendering. An empirical evaluation using absolute identification showed that our rendering method can improve perception performance in terms of correct identification rate and the amount of information transfer. The results suggest that perceptually transparent rendering can contribute to increasing the number of discrete vibrations that can be used for information delivery via a mobile device, e.g., for the priorities of phone calls.
Effect of pesticide exposure on HER-2/neu overexpression seen in patients with extensive stage small cell lung carcinoma.

PURPOSE The aim of this study was to evaluate the relationship, if any, between pesticide exposure and overexpression of the HER-2/neu oncoprotein in extensive stage small cell lung cancer (ESSCLC). EXPERIMENTAL DESIGN The records of all patients with a diagnosis of ESSCLC from January 1991 through April 2001 were reviewed in our retrospective study. Pesticide risk (herbicide and insecticide) was assessed by telephone interviews using a predetermined questionnaire with emphasis on type of exposure, use of protective measures, and duration of exposure. An exposure index was calculated (h/day x days/year x years), and patients with an index > 2400 h were considered as exposed. HER-2/neu overexpression was assessed by immunohistochemistry using the Hercep test developed by Dako. Statistical analysis was performed using SPSS-10. RESULTS A total of 193 patients (84 females and 109 males), with a mean age of 68.5 years (range, 42-90 years) were included in the study. Of these, 57 (29.5%) revealed HER-2/neu overexpression by immunohistochemistry. After adjusting for age, smoking, Eastern Cooperative Oncology Group score, and treatment, HER-2/neu overexpression was associated with a statistically significant diminished survival (P < 0.001; Mann-Whitney U test). We contacted 53 of 57 patients with overexpression and 121 of 136 patients without HER-2/neu overexpression to ascertain a history of pesticide exposure. Forty-one of 53 (77.4%) patients with HER-2/neu overexpression and 47 of the 121 patients without overexpression (38.8%) were exposed to pesticides. We found that patients with history of pesticide exposure had a higher risk of having HER-2/neu overexpression (odds ratio, 5.38; P < 0.01, 95% confidence interval, 2.5-11.2) CONCLUSIONS HER-2/neu is overexpressed in approximately 30% patients with ESSCLC and is associated with decreased survival. Also, pesticide exposure seems to be related to HER-2/neu overexpression seen in our patient population. Future studies are needed to validate our findings and also to determine which pesticide(s)/pesticide components are actually responsible for HER-2/neu overexpression seen in ESSCLC.
Retroviral DNA Integration

SUMMARY DNA integration is a unique enzymatic process shared by all retroviruses and retrotransposons. During integration, double-stranded linear viral DNA is inserted into the host genome in a process catalyzed by the virus-encoded integrase (IN). The mechanism involves a series of nucleophillic attacks, the first of which removes the terminal 2 bases from the 3′ ends of the long terminal repeats and of the second which inserts the viral DNA into the host genome. IN specifically recognizes the DNA sequences at the termini of the viral DNA, juxtaposing both ends in an enzyme complex that inserts the viral DNA into a single site in a concerted manner. Small duplications of the host DNA, characteristic of the viral IN, are found at the sites of insertion. At least two host proteins, HMG-I(Y) and BAF, have been shown to increase the efficiency of the integration reaction.
Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes

Neural precursor cells of the ventricular zone give rise to all neurons and glia of the central nervous system and rely for maintenance of their precursor characteristics on the closely related SoxB1 transcription factors Sox1, Sox2 and Sox3. We show in mouse spinal cord that, whereas SoxB1 proteins are usually downregulated upon neuronal specification, they continue to be expressed in glial precursors. In the oligodendrocyte lineage, Sox2 and Sox3 remain present into the early phases of terminal differentiation. Surprisingly, their deletion does not alter precursor characteristics but interferes with proper differentiation. Although a direct influence on myelin gene expression may be part of their function, we provide evidence for another mode of action. SoxB1 proteins promote oligodendrocyte differentiation in part by negatively controlling miR145 and thereby preventing this microRNA from inhibiting several pro-differentiation factors. This study presents one of the few cases in which SoxB1 proteins, including the stem cell factor Sox2, are associated with differentiation rather than precursor functions.
Mobile Services Acceptance Project Evaluation by Consumer: Toward an Integrated View

This research briefly introduces the Theory of Planned Behavior and the Technology Acceptance Model, extends the Technology Acceptance Model with Perceived Credibility based on the mobile services' characteristics. An Integrated Technology Acceptance Model, which comes from the Theory of Planned Behavior and the improved Technology Acceptance Model, is used to identify the factors that affect consumer intention to use mobile services. The results generated by Structural equation model indicate that the Integrated Technology Acceptance Model has significant effect on explaining behavioral intention to use mobile services.
The Capital Stock and Equilibrium Unemployment: A New Theoretical Perspective

By assuming Cobb-Douglas production technology, many well-known imperfectly competitive macroeconomic models of the labour market (e.g. Layard, Nickell and Jackman, 1991) imply that equilibrium unemployment is independent of the capital stock. This paper introduces a new notion of capacity into the standard framework. Specifically, we adapt the Cobb-Douglas production function so that when the capital-labour ratio drops below a certain threshold, the returns to labour fall while the returns to capital increase. Using this assumption, we show that equilibrium unemployment depends on the capital stock over a certain range. We also briefly discuss the generalisation for an endogenous capital stock.
Conversion of Human Umbilical Cord Mesenchymal Stem Cells in Wharton’s Jelly to Dopamine Neurons Mediated by the Lmx1a and Neurturin In Vitro: Potential Therapeutic Application for Parkinson’s Disease in a Rhesus Monkey Model

hUC-MSCs hold great promise in vitro neuronal differentiation and therapy for neurodegenerative disorders including Parkinson’s disease. Recent studies provided that Lmx1α play an important role in the midbrain dopamine cells differentiation. Neurturin is desired candidate gene for providing a neuroprotective to DA neurons. In this study, we investigated a novel neuronal differentiation strategy in vitro with Lmx1α and NTN. We transferred these two genes to hUC-MSCs by recombinant adenovirus combined with Lmx1α regulatory factor and other inductor to improve the efficiency of inducing. Then those induced cells were implanted into the striatum and substantia nigra of MPTP lesioned hemi-parkinsonian rhesus monkeys. Monkeys were monitored by using behavioral test for six months after implantation. The result showed that cells isolated from the umbilical cord were negative for CD45, CD34 and HLA-DR, but were positive for CD44, CD49d, CD29. After those cells were infected with recombinant adenovirus, RT-PCR result shows that both Lmx1α and NTN genes were transcribed in hUC-MSCs. We also observed that the exogenous were highly expressed in hUC-MSCs from immunofluorescence and western blot. Experiments in vitro have proved that secretion NTN could maintain the survival of rat fetal midbrain dopaminergic neurons. After hUC-MSCs were induced with endogenous and exogenous factors, the mature neurons specific gene TH, Pitx3 was transcripted and the neurons specific protein TH, β-tubulinIII, NSE, Nestin, MAP-2 was expressed in those differentiated cells. In addition, the PD monkeys, transplanted with the induced cells demonstrated the animals’ symptoms amelioration by the behavioral measures. Further more, pathological and immunohistochemistry data showed that there were neuronal-like cells survived in the right brain of those PD monkeys, which may play a role as dopaminergic neurons. The findings from this study may help us to better understand the inside mechanisms of PD pathogenesis and may also help developing effective therapy for Parkinson’s disease.
Latex Allergy Desensitization by Exposure Protocol: Five Case Reports

Two clinical reports dealing with subcutaneous desensitization to latex are available, but these treatments were reported to have significant side effects. To investigate an alternative method for latex desensitization, we present five cases of immunoglobulin E-mediated latex allergy in which a specific desensitization was successfully performed by means of an original exposure protocol. Five female patients with proven latex allergy underwent an original contact desensitization by wearing latex gloves daily, progressively increasing exposure to latex. All patients reached a final latex exposure time of 60 min in both hands. The desensitization protocol was completely successful in all patients. Twelve months after the beginning of the desensitization program, all the treated subjects were able to wear latex gloves daily without any clinical manifestations. This study provides evidence that a successful contact desensitization to latex is possible with no side effects. The adopted exposure protocol seems to be completely safe and effective. However, further studies in larger groups of subjects are necessary to fully confirm these preliminary results.
A compact high power wideband system

A number of recent efforts have been made to develop high power wideband sources for test and evaluation and general electronic disruption. Applied Physical Electronics, L.C. has developed technology covering 100 MHz to 400 MHz, and is continually working to broaden this area of coverage. The system is based on a single compact pulse power source, capable of delivering 1.7 GW peak power with repetition rates up to 200 Hz. Interchangeable dipole antennas are connected to the pulse power source via high voltage cabling, and are capable of radiating electric field strengths of several hundred kV/m. This paper presents the basic characteristics of the system, followed by experimental data.
Determinants of child health and development: the contribution of ALSPAC—a personal view of the birth cohort study

Britain has a unique experience of national longitudinal birth cohorts, but the Avon Longitudinal Study of Parents and Children differed in two major respects—it was based in one area rather than being a national sample, and it started in pregnancy rather than at birth or later in the first year. This paper outlines a personal selection of 10 topics, highlighting results from some of the 400+ papers that have already been published from this study. It indicates in particular how many childcare and domestic fashions were neither of benefit to the children (or their parents), the importance of pregnancy in regard to childhood conditions and the likely dangers of some common chemicals, whether in medications or domestic products.
Self-Face Recognition in Schizophrenia: An Eye-Tracking Study

Self-face recognition has been shown to be impaired in schizophrenia (SZ), according to studies using behavioral tasks implicating cognitive demands. Here, we employed an eye-tracking methodology, which is a relevant tool to understand impairments in self-face recognition deficits in SZ because it provides a natural, continuous and online record of face processing. Moreover, it allows collecting the most relevant and informative features each individual looks at during the self-face recognition. These advantages are especially relevant considering the fundamental role played by the patterns of visual exploration on face processing. Thus, this paper aims to investigate self-face recognition deficits in SZ using eye-tracking methodology. Visual scan paths were monitored in 20 patients with SZ and 20 healthy controls. Self, famous, and unknown faces were morphed in steps of 20%. Location, number, and duration of fixations on relevant areas were recorded with an eye-tracking system. Participants performed a passive exploration task (no specific instruction was provided), followed by an active decision making task (individuals were explicitly requested to recognize the different faces). Results showed that patients with SZ had fewer and longer fixations compared to controls. Nevertheless, both groups focused their attention on relevant facial features in a similar way. No significant difference was found between groups when participants were requested to recognize the faces (active task). In conclusion, using an eye tracking methodology and two tasks with low levels of cognitive demands, our results suggest that patients with SZ are able to: (1) explore faces and focus on relevant features of the face in a similar way as controls; and (2) recognize their own face.
Horizontal coseismic deformation of the 1999 Chi-Chi earthquake measured from SPOT satellite images: Implications for the seismic cycle along the western foothills of central Taiwan

[1] The 1999 Chi-Chi earthquake, Mw = 7.6, broke a major thrust fault along the western foothills of the Central Range of Taiwan. We have measured the horizontal coseismic displacement field by correlating optical satellite images acquired before and after the earthquake. These data reveal the fault trace and a clockwise rotation of surface displacements toward the north with much larger displacements and strain in the hanging wall. At the surface, coseismic slip increases from 5–6 m near the epicenter to 10–11 m to the north. In the epicentral area, we observe a left-lateral strike-slip zone trending N125� E, and farther north, a fault zone trending N-S with a right-lateral component. The data were modeled using elastic dislocations. The fault geometry consists of a shallow
Assessing the computational complexity of multilayer subgraph detection

Abstract Multilayer graphs consist of several graphs, called layers, where the vertex set of all layers is the same but each layer has an individual edge set. They are motivated by real-world problems where entities (vertices) are associated via multiple types of relationships (edges in different layers). We chart the border of computational (in)tractability for the class of subgraph detection problems on multilayer graphs, including fundamental problems such as maximum-cardinality matching, finding certain clique relaxations, or path problems. Mostly encountering hardness results, sometimes even for two or three layers, we can also spot some islands of computational tractability.
Subjective and objective evaluation of frontal smile esthetics in patients with facial asymmetry-a comparative cross-sectional study.

AIM AND OBJECTIVES To analyze the relationship between subjective and objective evaluations of pre-treatment posed smiles in patients with facial asymmetry and to assess the influence of dentofacial structures involved in asymmetry on the perception of smile attractiveness. SAMPLE Thirty-five patients (25 males and 10 females) between 18 and 25 years of age with facial asymmetry were selected. MATERIALS AND METHODS Pre-treatment clinical photographs of posed smiles were subjectively evaluated by a panel of 20 orthodontists, 20 oral surgeons, and 20 laypersons. A customized Smile Mesh program was used for objective evaluation of the same smiles. Direct comparison among three smile groups (unattractive, slightly attractive, and attractive) for different Smile Mesh measurements was carried out using two-way anova test. Additionally, linear regression was performed to evaluate whether these measurements could predict the attractiveness of captured smiles. RESULTS Patients with 'slightly attractive' smiles had a significantly greater distance between the incisal margin of the maxillary central incisor and the lower lip during smiling. The Smile Index was significantly greater in attractive smiles. However, based on the coefficients of linear regression, no objectively gathered measurement could predict smile attractiveness. CONCLUSIONS Attractiveness or unattractiveness of smiles in patients with facial asymmetry could not be predicted by any measurement of Smile Mesh. The presence of facial asymmetry did not significantly influence the perception of smile esthetics.
Role of the Mouse Retinal Photoreceptor Ribbon Synapse in Visual Motion Processing for Optokinetic Responses

The ribbon synapse is a specialized synaptic structure in the retinal outer plexiform layer where visual signals are transmitted from photoreceptors to the bipolar and horizontal cells. This structure is considered important in high-efficiency signal transmission; however, its role in visual signal processing is unclear. In order to understand its role in visual processing, the present study utilized Pikachurin-null mutant mice that show improper formation of the photoreceptor ribbon synapse. We examined the initial and late phases of the optokinetic responses (OKRs). The initial phase was examined by measuring the open-loop eye velocity of the OKRs to sinusoidal grating patterns of various spatial frequencies moving at various temporal frequencies for 0.5 s. The mutant mice showed significant initial OKRs with a spatiotemporal frequency tuning (spatial frequency, 0.09 ± 0.01 cycles/°; temporal frequency, 1.87 ± 0.12 Hz) that was slightly different from the wild-type mice (spatial frequency, 0.11 ± 0.01 cycles/°; temporal frequency, 1.66 ± 0.12 Hz). The late phase of the OKRs was examined by measuring the slow phase eye velocity of the optokinetic nystagmus induced by the sinusoidal gratings of various spatiotemporal frequencies moving for 30 s. We found that the optimal spatial and temporal frequencies of the mutant mice (spatial frequency, 0.11 ± 0.02 cycles/°; temporal frequency, 0.81 ± 0.24 Hz) were both lower than those in the wild-type mice (spatial frequency, 0.15 ± 0.02 cycles/°; temporal frequency, 1.93 ± 0.62 Hz). These results suggest that the ribbon synapse modulates the spatiotemporal frequency tuning of visual processing along the ON pathway by which the late phase of OKRs is mediated.
The deformation of solids by liquid impact at supersonic speeds

A study has been made of the deformation of solids at high rates of strain which are produced by the impact of a small cylinder or jet of liquid on the surface of the solid. A method is developed for projecting this jet against the solid at velocities up to 1200 m/s. The subsequent deformation of the solid under impact and the behaviour of the liquid is observed by high-speed photographic methods. The magnitude and duration of the impact load are also measured by using a piezo-electric transducer. The mode of deformation of the solid has been investigated for plastic, elastic and brittle materials. There is evidence that the liquid jet, on impact, behaves initially in a compressible manner. Part of the deformation is due to these compressible effects and part to the shearing action of the liquid flowing at very high speeds across the surface. If the head of the jet has an appropriate shape (e.g. wedge shaped) the velocity of flow across the surface may be much greater than the velocity of approach. It is found that there are five general types of deformation produced in the solid. There are (i) circumferential surface fractures, (ii) subsurface flow and fractures, (iii) large-scale plastic deformation, (iv) shear deformation around the periphery of the impact zone, and (v) fracture due to the reflexion and interference of stress waves. The predominating mode of deformation depends primarily on the mechanical properties of the solid and on the velocity of impact. The observations have a bearing on the practical problem of the erosion of aircraft flying at high speed through rain and on the erosion of turbine blades.
POWER SERIES SOLUTION OF A NONLINEAR SCHR ¨ ODINGER EQUATION

A slightly modified variant of the cubic periodic one-dimensional non- linear Schrodinger equation is shown to be well-posed, in a relatively weak sense, in certain function spaces wider than L 2 . Solutions are constructed as sums of infinite series of multilinear operators applied to initial data, and these multilinear operators are analyzed directly.
Benefits and barriers among volunteer teaching faculty: comparison between those who precept and those who do not in the core pediatrics clerkship

Background Community-based outpatient experiences are a core component of the clinical years in medical school. Central to the success of this experience is the recruitment and retention of volunteer faculty from the community. Prior studies have identified reasons why some preceptors volunteer their time however, there is a paucity of data comparing those who volunteer from those who do not. Methods A survey was developed following a review of previous studies addressing perceptions of community-based preceptors. A non-parametric, Mann–Whitney U test was used to compare active preceptors (APs) and inactive preceptors (IPs) and all data were analyzed in SPSS 20.0. Results There was a 28% response rate. Preceptors showed similar demographic characteristics, valued intrinsic over extrinsic benefits, and appreciated Continuing Medical Education (CME)/Maintenance of Certification (MOC) opportunities as the highest extrinsic reward. APs were more likely to also precept at the M1/M2 level and value recognition and faculty development opportunities (p<0.05). IPs denoted time as the most significant barrier and, in comparison to APs, rated financial compensation as more important (p<0.05). Conclusions Community preceptors are motivated by intrinsic benefits of teaching. Efforts to recruit should initially focus on promoting awareness of teaching opportunities and offering CME/MOC opportunities. Increasing the pool of preceptors may require financial compensation.