Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Video Simulated Presence to reduce resistance to care and increase participation of adults with dementia

Background: Cognitive and functional decline in dementia generally impairs performance of basic care activities. Staff assistance during these activities frequently results in confusion, anxiety, and distress, expressed through resistance to care (RTC). Methods: A single-system ABA withdrawal design (n = 1) evaluated the effect of video-simulated presence (VSP) for decreasing RTC and increasing participation. A family member pre-recorded videos for use during episodes of RTC, in which the family member spoke directly to the participant to encourage participation. Results: Introduction of the VSP significantly reduced RTC during the basic care tasks of feeding and talking medication. This effect was reversed when the intervention was withdrawn. Participation increased following VSP, demonstrating clear trends toward clinical significance. Conclusions: This person-centered intervention, based on VSP of a family member, provides encouraging results for reducing RTC and increasing participation of adults with dementia in basic care tasks.
HYPOTHALAMIC LESIONS IN HEAD INJURY

cells were depleted. From the levels of metabolite concentrations it was not clear if the cause of the decrease in the energy-rich phosphates and the increased anaerobic glycolysis could be found in a specific disturbance of oxidative phosphorylization-for example, ferment inhibition-or in insufficiency of oxygen supply. The latter seamed the most likely explanation. On the basis of these investigations it was concluded that the twin aims of the therapy of cerebral oedema were the removal of increased extracellular fluid in the white matter and restitution of normal vascular permeability. It was also pointed out that oxygen deficiency, due to respiratory embarrassment, shock, or hyperthermia was likely to cause irreversible damage to oedematous tissue more readily than to normal tissue. The preceding two papers were discussed by W. Wesemann (Giessen) and A. R. Taylor (Belfast).
Spatio-temporal Remodeling of Functional Membrane Microdomains Organizes the Signaling Networks of a Bacterium

Lipid rafts are membrane microdomains specialized in the regulation of numerous cellular processes related to membrane organization, as diverse as signal transduction, protein sorting, membrane trafficking or pathogen invasion. It has been proposed that this functional diversity would require a heterogeneous population of raft domains with varying compositions. However, a mechanism for such diversification is not known. We recently discovered that bacterial membranes organize their signal transduction pathways in functional membrane microdomains (FMMs) that are structurally and functionally similar to the eukaryotic lipid rafts. In this report, we took advantage of the tractability of the prokaryotic model Bacillus subtilis to provide evidence for the coexistence of two distinct families of FMMs in bacterial membranes, displaying a distinctive distribution of proteins specialized in different biological processes. One family of microdomains harbors the scaffolding flotillin protein FloA that selectively tethers proteins specialized in regulating cell envelope turnover and primary metabolism. A second population of microdomains containing the two scaffolding flotillins, FloA and FloT, arises exclusively at later stages of cell growth and specializes in adaptation of cells to stationary phase. Importantly, the diversification of membrane microdomains does not occur arbitrarily. We discovered that bacterial cells control the spatio-temporal remodeling of microdomains by restricting the activation of FloT expression to stationary phase. This regulation ensures a sequential assembly of functionally specialized membrane microdomains to strategically organize signaling networks at the right time during the lifespan of a bacterium.
Scaling of N-body calculations

We report results of collisional N-body simulations aimed at studying the N dependence of the dynamical evolution of star clusters. Our clusters consist of equal-mass stars and are in virial equilibrium. Clusters moving in external tidal fields and clusters limited by a cut-off radius are simulated. Our main focus is to study the dependence of the lifetimes of the clusters on the number of cluster stars and the chosen escape condition.
Risk factors for incidental prostate cancer—who should not undergo vaporization of the prostate for benign prostate hyperplasia?

Vaporization of the prostate (e.g., using laser devices) for treatment of benign prostatic hyperplasia does not allow for subsequent histological examination. Therefore, patients should be counseled about the risk of missing an incidental prostate cancer (incPCa). In this study the risk of an incPCa was determined based on all preoperative parameters.
Platform for Distributed 3D Gaming

Video games are typically executed on Windows platforms with DirectX API and require high performance CPUs and graphics hardware. For pervasive gaming in various environments like at home, hotels, or internet cafes, it is beneficial to run games also on mobile devices and modest performance CE devices avoiding the necessity of placing a noisy workstation in the living room or costly computers/consoles in each room of a hotel. This paper presents a new cross-platform approach for distributed 3D gaming in wired/wireless local networks. We introduce the novel system architecture and protocols used to transfer the game graphics data across the network to end devices. Simultaneous execution of video games on a central server and a novel streaming approach of the 3D graphics output to multiple end devices enable the access of games on low cost set top boxes and handheld devices that natively lack the power of executing a game with high-quality graphical output.
The Compromised Recognition of Turnip Crinkle Virus1 Subfamily of Microrchidia ATPases Regulates Disease Resistance in Barley to Biotrophic and Necrotrophic Pathogens1[C][W][OPEN]

Barley microrchidia ATPases bind to DNA, have endonuclease activity, and regulate plant immunity. MORC1 and MORC2, two of the seven members of the Arabidopsis (Arabidopsis thaliana) Compromised Recognition of Turnip Crinkle Virus1 subfamily of microrchidia Gyrase, Heat Shock Protein90, Histidine Kinase, MutL (GHKL) ATPases, were previously shown to be required in multiple layers of plant immunity. Here, we show that the barley (Hordeum vulgare) MORCs also are involved in disease resistance. Genome-wide analyses identified five MORCs that are 37% to 48% identical on the protein level to AtMORC1. Unexpectedly, and in clear contrast to Arabidopsis, RNA interference-mediated knockdown of MORC in barley resulted in enhanced basal resistance and effector-triggered, powdery mildew resistance locus A12-mediated resistance against the biotrophic powdery mildew fungus (Blumeria graminis f. sp. hordei), while MORC overexpression decreased resistance. Moreover, barley knockdown mutants also showed higher resistance to Fusarium graminearum. Barley MORCs, like their Arabidopsis homologs, contain the highly conserved GHKL ATPase and S5 domains, which identify them as members of the MORC superfamily. Like AtMORC1, barley MORC1 (HvMORC1) binds DNA and has Mn2+-dependent endonuclease activities, suggesting that the contrasting function of MORC1 homologs in barley versus Arabidopsis is not due to differences in their enzyme activities. In contrast to AtMORCs, which are involved in silencing of transposons that are largely restricted to pericentromeric regions, barley MORC mutants did not show a loss-of-transposon silencing regardless of their genomic location. Reciprocal overexpression of MORC1 homologs in barley and Arabidopsis showed that AtMORC1 and HvMORC1 could not restore each other’s function. Together, these results suggest that MORC proteins function as modulators of immunity, which can act negatively (barley) or positively (Arabidopsis) dependent on the species.
Swarms of Femtosats for Synthetic Aperture Applications

The Silicon Wafer Integrated Femtosatellites (SWIFT) Swarm Project presents a new paradigm-shifting definition of spacecraft technology that can enable flight of swarms of fully capable femtosats. One of the most important applications of SWIFT is a distributed aperture array. New swarm Golay array configurations are introduced and shown to dramatically increase the effective diameter derived from optical performance metrics. A system cost analysis based on this comparison justifies deploying a large number of spacecraft for sparse aperture applications.
Effects of Pioglitazone on Lipoproteins, Inflammatory Markers, and Adipokines in Nondiabetic Patients with Metabolic Syndrome

Objective—The purpose of this research was to evaluate the short-term effects of pioglitazone (PIO) on high-density lipoprotein cholesterol (HDL-C) and other metabolic parameters in nondiabetic patients with metabolic syndrome (MetSyn). Methods and Results—Sixty nondiabetic adults with low HDL-C and MetSyn were randomized to PIO or matching placebo for 12 weeks. PIO increased HDL-C by 15% and 14% at 6 and 12 weeks, respectively, compared with placebo (P<0.001). Changes in HDL-C were correlated to changes in adiponectin (r=0.34; P=0.01) but not to changes in insulin resistance. PIO did not affect serum triglycerides or low-density lipoprotein (LDL) cholesterol concentrations but reduced the number of small LDL particles by 18% (P<0.001). PIO reduced median C-reactive protein levels by 31% (P<0.001) and mean resistin levels by 10% (P=0.02) while increasing mean serum levels of adiponectin by 111% (P<0.001) compared with placebo. PIO did not affect weight and modestly decreased insulin resistance. Conclusions—In nondiabetic patients with low HDL-C and MetSyn, PIO significantly raised HDL-C and favorably affected lipoprotein particle size, markers of inflammation, and adipokines without changes in triglycerides, LDL-C, or weight. These results suggest that PIO has direct effects on HDL, which may contribute to its antiatherogenic effects.
Seasonal variation of haemoglobin A1c in a Portuguese adult population.

OBJECTIVE Haemoglobin A1c (Hb A1c) is routinely used for monitoring glycemic control in patients with diabetes. Hb A1c seasonal fluctuations can be directly related to different biological, geographical and cultural influences. Our purpose was to evaluate seasonal variation of Hb A1c in a hospital-based adult population over a period of 5 years. MATERIALS AND METHODS We analyzed retrospectively monthly Hb A1c mean values (DCCT, %) based on all the assays performed to adult patients at a tertiary care university Portuguese hospital between 2008-2012. RESULTS We obtained 62,384 Hb A1c valid measurements, with a peak level found in January-February (7.1%), a trough in August-October (6.8%) and an average peak-to-trough amplitude value of 0.3%. This trend was observed in both genders and age subgroups evaluated. CONCLUSIONS There is a Hb A1c circannual seasonal pattern with peak levels occurring in winter months in this Portuguese population. This finding should be recognized in daily clinical practice to warrant better clinical and epidemiological interpretation of Hb A1c values.
Online grocery systems design through task analysis

Purpose – Modelling users' interactions online is envisaged to allow developers to increase the usability of online systems and will aid system developers in building better systems to meet users' needs, hereby creating better system design processes. This paper aims to investigate this issue.Design/methodology/approach – The normative task model that was developed in this paper was created through an expert review of 14 online grocery stores, using a reverse engineering technique to model the features of the stores' ordering process.Findings – The research identified three main areas of user experience when undertaking the process of adding a product to an online trolley: attempting to retrieve the product, receiving the results of the retrieval attempt, and adding the product to the trolley. These three classifications were used as the basis for an analysis of errors.Practical implications – The findings present a model that can be used to further understand the processes of customers as they engage in .
Proteomic study of human bronchoalveolar lavage fluids from smokers with chronic obstructive pulmonary disease by combining surface‐enhanced laser desorption/ionization‐mass spectrometry profiling with mass spectrometric protein identification

Bronchoalveolar lavage fluid (BALF) is an important diagnostic source to investigate cellular and molecular changes in the course of lung disorders. The pattern of soluble proteins in BALF obtained from patients at different stages of respiratory disorders may provide deeper insights in the molecular mechanisms of the disease. We used surface‐enhanced laser desorption/ionization mass spectrometry (MS) for differential protein display combined with reversed‐phase chromatography and subsequent matrix‐assisted laser desorption/ionization‐MS or nanoliquid chromatography MS/MS analysis for protein identification to compare the protein pattern of BALF samples obtained from ten smokers suffering from chronic obstructive pulmonary disease (COPD), eight clinically asymptomatic smokers, and eight nonsmokers without pulmonary disease. In this context, we were able to identify small proteins and peptides, either differentially expressed or secreted in the course of COPD or in a direct response to cigarette smoke. The concentrations of neutrophil defensins 1 and 2, S100A8 (calgranulin A), and S100A9 (calgranulin B) were elevated in BALFs of smokers with COPD when compared to asymptomatic smokers. Increased concentrations in S100A8 (Calgranulin A), salivary proline‐rich peptide P‐C, and lysozyme C were detected in BALFs of asymptomatic smokers when compared to nonsmokers, whereas salivary proline‐rich peptide P‐D and Clara cell phospholipid‐binding protein (CC10) were reduced in their concentration. The identified proteins and peptides might be useful in the future as diagnostic markers for smoke‐induced lung irritations and COPD.
Vigilante: end-to-end containment of internet worms

Worm containment must be automatic because worms can spread too fast for humans to respond. Recent work has proposed network-level techniques to automate worm containment; these techniques have limitations because there is no information about the vulnerabilities exploited by worms at the network level. We propose Vigilante, a new end-to-end approach to contain worms automatically that addresses these limitations. Vigilante relies on collaborative worm detection at end hosts, but does not require hosts to trust each other. Hosts run instrumented software to detect worms and broadcast self-certifying alerts (SCAs) upon worm detection. SCAs are proofs of vulnerability that can be inexpensively verified by any vulnerable host. When hosts receive an SCA, they generate filters that block infection by analysing the SCA-guided execution of the vulnerable software. We show that Vigilante can automatically contain fast-spreading worms that exploit unknown vulnerabilities without blocking innocuous traffic.
The structure of Turkish trait-descriptive adjectives.

This description of the Turkish lexical project reports some initial findings on the structure of Turkish personality-related variables. In addition, it provides evidence on the effects of target evaluative homogeneity vs. heterogeneity (e.g., samples of well-liked target individuals vs. samples of both liked and disliked targets) on the resulting factor structures, and thus it provides a first test of the conclusions reached by D. Peabody and L. R. Goldberg (1989) using English trait terms. In 2 separate studies, and in 2 types of data sets, clear versions of the Big Five factor structure were found. And both studies replicated and extended the findings of Peabody and Goldberg; virtually orthogonal factors of relatively equal size were found in the homogeneous samples, and a more highly correlated set of factors with relatively large Agreeableness and Conscientiousness dimensions was found in the heterogeneous samples.
BIM-supported planning process for sustainable buildings - Process Simulation and Evaluation through Exploratory Research

One of the consequences of increasing complexity of planning and construction process is a large number of disciplines participating in planning process, all of whom use wide spectrum of specialised visualisation, simulation or calculation tools. With the maturing of BIM tools and their increasing presence on the market, the hope for possibility of maximisation of process-integration through joining all of the different building-representation models in one single joint model came up. The planning practice reality however demonstrated a number of upcoming problems with BIM implementation on technical- (heterogonous data, interfaces, large data volumes) but even more so on process-level (question of responsibilities and work-load distribution, lacking standards or conventions on buildingrepresentation). The optimal data management, transfer and synchronisation within very inhomogeneous software context, such as employed within construction projects, require enormous organization, coordination and communication effort in the earliest design-phases. The BIM implementation implies therefore on necessity of fundamental rethinking of the traditional design process; for which the knowledge is still largely lacking. In this paper we will present the first results of the exploratory research carried out at the Vienna University of Technology. We simulated a BIM-supported multi-disciplinary planning process with students of architecture, structural engineering and building physics, using several BIM-software tools. First insights on process-quality, such as team-, process- and technology satisfaction, as well as conflict- and stress levels will be presented. We were able to identify numerous technical problems related to the data transfer and inconsistencies in translation, which resulted in participant dissatisfaction and significant increasing of workloads. The first results imply on the importance of traditional process-design techniques such as face-to face communication, coordination and work-load allocation between the teammembers in order to conduct efficient BIM-supported process; as well as on urgent need for advancement of the tools in terms of data transfer- and exchange. In the next step, using mandatory protocols and timesheets, a detailed statistical analysis of the people-processtechnology issues will be conducted, as well as comparison of „Open-Platform-BIM“ to „OnePlatform-BIM” model.
The Antecedents of Workaholism and other Work Behaviors

This paper presents a conceptual model of the work effort decision of individuals and thereby advances our understanding of workaholism and other patterns of high or low work involvement and high or low work enjoyment. Researchers have categorized eight main types of work behaviors using the triad (i) quantity of work effort supplied, (ii) psychic need to work, and (iii) enjoyment derived from work. Workaholics (or work addicts), ‘enthusiastic workaholics’ and work enthusiasts’ all work long hours but only the first two groups are driven by a psychic need to work, and only the latter two groups gain high enjoyment from work. While the positive and negative consequences of long work hours have been discussed at considerable length, the antecedents of the individual’s decision to supply work effort have not previously been explored in depth. We build a model that links together the three constructs of the ‘workaholism triad’ and also incorporates the individual’s economic orientation, leisure orientation, and perquisite orientation. Accordingly we distinguish four main drivers of work effort levels, and argue that only one of these is associated with the classic view of workaholism. We identify three distinct types of work enthusiast and thus extend the typology of workers to ten groups, and offer speculative reasons for the high/low work effort and work enjoyment levels associated with each group. We offer a series of propositions that are suggested by the conceptual model for further research into this important area.
A new species of Plesiosorex (Mammalia, Eulipotyphla) from the Early Miocene of Japan: first record of the genus from East Asia

Abstract A nearly complete dentary with preserved i2, p3 and m1 of a relatively large soricomorph from the Dota locality, Kani Basin, Early Miocene (ca. 18.5 Ma), Nakamura Formation of the Mizunami Group in central Japan, is described as a new species of Plesiosorex. It represents the first record of the genus in East Asia. Plesiosorex fejfari sp. nov. has a slender dentary, posteriorly elongated angular and condyloid processes, p3 with two roots, and m1 without hypoconulid or cingulid. Cladistic analysis of Butselia gracilis and seven species of Plesiosorex shows that Butselia is basally positioned with respect to Plesiosorex, and it seems likely that Plesiosorex originated in Europe at the beginning of the Miocene and expanded its distribution to East Asia and North America during the Early Miocene. Two Middle Miocene North American species are more closely related to each other than to European species of the same age.
Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana

Bioassay-guided fractionation of an ethanol extract of the pericarps of Garcinia mangostana led to the isolation of two new prenylated xanthones, named 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-8-(3-hydroxy-3-methylbutyl)-xanthone (1) and 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (2), together with the five known compounds garcinones C (3) and D (4), gartanin (5), xanthone I (6), and γ-mangostin (7). Their structures were elucidated primarily based on MS and NMR data. Compounds 1–7 showed significant cytotoxic activities against various human cancer cell lines.
Diagnostic Accuracy of Lipopolysaccharide-Binding Protein as Biomarker for Sepsis in Adult Patients: A Systematic Review and Meta-Analysis

Introduction Lipopolysaccharide-binding protein (LBP) is widely reported as a biomarker to differentiate infected from non-infected patients. The diagnostic use of LBP for sepsis remains a matter of debate. We aimed to perform a systematic review and meta-analysis to assess the diagnostic accuracy of serum LBP for sepsis in adult patients. Methods We performed a systematic review and meta-analysis to assess the accuracy of LBP for sepsis diagnosis. A systematic search in PubMed and EMBASE for studies that evaluated the diagnostic role of LBP for sepsis through December 2015 was conducted. We searched these databases for original, English language, research articles that studied the diagnostic accuracy between septic and non-septic adult patients. Sensitivity, specificity, and other measures of accuracy, such as diagnostic odds ratio (DOR) and area under the receiver operating characteristic curve (AUC) of LBP were pooled using the Hierarchical Summary Receiver Operating Characteristic (HSROC) method. Results Our search returned 53 reports, of which 8 fulfilled the inclusion criteria, accounting for 1684 patients. The pooled sensitivity and specificity of LBP for diagnosis of sepsis by the HSROC method were 0.64 (95% CI: 0.56–0.72) and 0.63 (95% CI: 0.53–0.73), respectively. The value of the DOR was 3.0 (95% CI: 2.0–4.0) and the AUC was 0.68 (95% CI: 0.64–0.72). Meta-regression analysis revealed that cut-off values accounted for the heterogeneity of sensitivity and sample size (> = 150) accounted for the heterogeneity of specificity. Conclusions Based on the results of our meta-analysis, LBP had weak sensitivity and specificity in the detection of sepsis. LBP may not be practically recommended for clinical utilization as a single biomarker.