Miracle-dz/UniFAR-FTUs huggingface dataset:
Unsteady MHD free convective heat transfer flow along a vertical porous flat plate with internal heat generation

In this study, a similarity analysis is made for an unsteady two-dimensional MHD free convective and heat trans- fer flow of a viscous incompressible fluid along a vertical flat plate with internal heat generation/absorption. The governing time-dependent boundary-layer equations are reduced to non-linear ordinary differential equations by introducing a similarity transformation. The obtained similarity equation for both steady and unsteady cases have been compared with previously published work and excellent agreement is found. The resulting local sim- ilarity equations for the unsteady flow have been solved numerically by applying Nachtsheim-Swigert shooting iteration technique along with sixth order Runge-Kutta integration scheme. Numerical results for the dimen- sionless velocity and temperature profiles as well as the local skin-friction coefficient and local Nusselt number are displayed both by graphically and numerically for different values of the physical parameters entering into the problem.The significance of the physical parameters on the flow field is discussed in detail.The results shows that the velocity profile and the temperature profile is much pronounced with the increasing value of heat gen- eration and unsteadiness parameter but the opposite effect can be found for suction parameter and Prandlt number. Also, the result shows that the values of skin-friction and wall heat transfer are strongly influenced by unstediness and heat generation parameter. MSC: 76M55 65L10
Price Discovery in Holdr Security Baskets and the Underlying Stocks

HOLDRs, a type of basket security, enable investors to purchase an entire industry sector with one transaction. We examine the link between HOLDR basket securities and the underlying stocks. Contrary to the findings of studies using other basket securities, with HOLDRs we find that the price of the portfolio of underlying securities is more informative than and leads the HOLDR (basket) price. Our results are the first empirical confirmation of Subrahmanyam's (1991) theoretical model of the interaction of the redundant security with its underlying assets.
The software value map — an exhaustive collection of value aspects for the development of software intensive products

In software intensive products such as cars or telecom systems, software has traditionally been associated with cost, and there has been no real perception of its value in relation to the entire product offering. However, because software is becoming a larger part of the main competitive advantage, driving innovation and product differentiation, hardware is becoming more standardized, thus the valuation of software is becoming critical. In existing literature, several value constructs and corresponding valuation/measurement solutions needed for making decisions about software product development are presented. However, the contributions are often isolated with respect to a certain perspective such as focusing on product's internal or external quality aspects only. Consequently, a complete view of value constructs relevant from different perspectives required for making decisions about software product development is missing. This paper presents a consolidated view of the software value concept utilizing the major perspectives and introduces a software value map. The created value map was evaluated through an industry case study through the development of impact evaluation patterns, which were subsequently used by professionals in industry, and experiences gathered. During industry evaluation, practitioners found substantial benefits of having a consolidated, vastly improved, and extended value aspect's view of software. Copyright © 2012 John Wiley & Sons, Ltd.
Scanning-helium-ion-beam lithography with hydrogen silsesquioxane resist

A scanning-helium-ion-beam microscope is now commercially available. This microscope can be used to perform lithography similar to, but of potentially higher resolution than, scanning electron-beam lithography. This article describes the control of this microscope for lithography via beam steering/blanking electronics and evaluates the high-resolution performance of scanning helium-ion-beam lithography. The authors found that sub-10nm-half-pitch patterning is feasible. They also measured a point-spread function that indicates a reduction in the micrometer-range proximity effect typical in electron-beam lithography.
Multi-layer Representation Learning for Medical Concepts

Proper representations of medical concepts such as diagnosis, medication, procedure codes and visits from Electronic Health Records (EHR) has broad applications in healthcare analytics. Patient EHR data consists of a sequence of visits over time, where each visit includes multiple medical concepts, e.g., diagnosis, procedure, and medication codes. This hierarchical structure provides two types of relational information, namely sequential order of visits and co-occurrence of the codes within a visit. In this work, we propose Med2Vec, which not only learns the representations for both medical codes and visits from large EHR datasets with over million visits, but also allows us to interpret the learned representations confirmed positively by clinical experts. In the experiments, Med2Vec shows significant improvement in prediction accuracy in clinical applications compared to baselines such as Skip-gram, GloVe, and stacked autoencoder, while providing clinically meaningful interpretation.
The photometric properties of isolated early‐type galaxies

Isolated galaxies are important because they probe the lowest density regimes inhabited by galaxies. We define a sample of 36 nearby isolated early-type galaxies for further study. Our isolation criteria require them to have no comparable-mass neighbours within 2 B-band magnitudes, 0.67 Mpc in the plane of the sky and 700 km s -1 in recession velocity. New wide-field optical imaging of 10 isolated galaxies with the Anglo-Australian Telescope confirms their early-type morphology and relative isolation. We also present imaging of four galaxy groups as a control sample. The isolated galaxies are shown to be more gravitationally isolated than the group galaxies. We find that the isolated early-type galaxies have a mean effective colour of (B - R) e = 1.54 ± 0.14, similar to their high-density counterparts. They reveal a similar colour-magnitude relation slope and small intrinsic scatter to cluster ellipticals. They also follow the Kormendy relation of surface brightness versus size for luminous cluster galaxies. Such properties suggest that the isolated galaxies formed at a similar epoch to cluster galaxies, such that the bulk of their stars are very old. However, our galaxy modelling reveals evidence for dust lanes, plumes, shells, boxy and disc isophotes in four out of nine galaxies. Thus at least some isolated galaxies have experienced a recent merger/accretion event, which may have induced a small burst of star formation. We derive luminosity functions for the isolated galaxies and find a faint slope of -1.2, which is similar to the 'universal' slope found in a wide variety of environments. We examine the number density distribution of galaxies in the field of the isolated galaxies. Only the very faintest dwarf galaxies (M R ≥ -15.5) appear to be associated with the isolated galaxies, whereas any intermediate-luminosity galaxies appear to lie in the background. Finally, we discuss possible formation scenarios for isolated early-type galaxies. Early epoch formation and a merger/accretion of galaxies are possible explanations. The collapse of a large, virialized group is an unlikely explanation, but that of a poor group remains viable.
Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness

Gulf War Illness (GWI) is a multi‐symptom disorder with features characteristic of persistent sickness behavior. Among conditions encountered in the Gulf War (GW) theater were physiological stressors (e.g., heat/cold/physical activity/sleep deprivation), prophylactic treatment with the reversible AChE inhibitor, pyridostigmine bromide (PB), the insect repellent, N,N‐diethyl‐meta‐toluamide (DEET), and potentially the nerve agent, sarin. Prior exposure to the anti‐inflammatory glucocorticoid, corticosterone (CORT), at levels associated with high physiological stress, can paradoxically prime the CNS to produce a robust proinflammatory response to neurotoxicants and systemic inflammation; such neuroinflammatory effects can be associated with sickness behavior. Here, we examined whether CORT primed the CNS to mount neuroinflammatory responses to GW exposures as a potential model of GWI. Male C57BL/6 mice were treated with chronic (14 days) PB/ DEET, subchronic (7–14 days) CORT, and acute exposure (day 15) to diisopropyl fluorophosphate (DFP), a sarin surrogate and irreversible AChE inhibitor. DFP alone caused marked brain‐wide neuroinflammation assessed by qPCR of tumor necrosis factor‐α, IL6, chemokine (C‐C motif) ligand 2, IL‐1β, leukemia inhibitory factor, and oncostatin M. Pre‐treatment with high physiological levels of CORT greatly augmented (up to 300‐fold) the neuroinflammatory responses to DFP. Anti‐inflammatory pre‐treatment with minocycline suppressed many proinflammatory responses to CORT+DFP. Our findings are suggestive of a possible critical, yet unrecognized interaction between the stressor/environment of the GW theater and agent exposure(s) unique to this war. Such exposures may in fact prime the CNS to amplify future neuroinflammatory responses to pathogens, injury, or toxicity. Such occurrences could potentially result in the prolonged episodes of sickness behavior observed in GWI. Gulf War (GW) veterans were exposed to stressors, prophylactic medicines and, potentially, nerve agents in theater. Subsequent development of GW Illness, a persistent multi‐symptom disorder with features characteristic of sickness behavior, may be caused by priming of the CNS resulting in exaggerated neuroinflammatory responses to pathogens/insults. Nerve agent, diisopropyl fluorophosphate (DFP), produced a neuroinflammatory response that was exacerbated by pre‐treatment with levels of corticosterone simulating heightened stressor conditions. While prophylactic treatments reduced DFP‐induced neuroinflammation, this effect was negated when those treatments were combined with corticosterone.
A Study of Relatıonship between Perceived Organızational Justice and Individualism Collectivism Values Among Academic Staff

The purpose of this study is to investigate the relationship between the individuals’ perceptions of justice in the organizations they work in and the personality tendencies of individualism or collectivism they have. For that reason, firstly the concept of organizational justice and the values of collectivism and individualism were explained; their relationship was mentioned through theoretical and empirical studies in the literature. As measurement tool, survey method was used. The surveys were conducted on 133 academicians working at Bartin University which is one of the state universities in Turkey. As a result of doing reliability analysis and factor analysis, the last form of scale was given. The perceived organizational justice handled in the scale was composed of three dimensions which are distributive justice, procedural justice and interactional justice; and despite individualism and collectivism have four sub-dimensions (horizontal individualism, vertical individualism, horizontal collectivism and vertical collectivism) this was not taken into account in the study and they were discussed from only individualism and collectivism dimensions. In consequence of ANOVA analyses performed, it is found that there is a low relation between collectivism value and distributive justice as well as between individualism value and interactional justice. The findings of ANOVA analysis showed that in the demographic characteristics only the title variable groups showed significant differences between interactional justice and individualism. By multi-regression analysis, it is seen that as much as procedural justice increases the exhibited collectivism characteristic increases, in similar way as much as distributive justice increases the collectivism characteristic increases. There was no obvious significant correlation between individualism variable and justice dimensions.
Intra-Arterial Chemotherapy as Primary Therapy for Retinoblastoma in Infants Less than 3 Months of Age: A Series of 10 Case-Studies

Purpose Retinoblastoma is the most common primary malignant intra-ocular tumor in children. Although intra-arterial chemotherapy (IAC) by selectively infusing chemotherapy through the ophthalmic artery has become an essential technique in the treatment of advanced intra-ocular retinoblastoma in children, the outcome of IAC as primary therapy for infants less than 3 months of age remains unknown. In this retrospective study, we reviewed the outcome of IAC as primary therapy for retinoblastoma in infants less than 3 months of age. Methods We retrospectively reviewed ten retinoblastoma patients attending our center from January 2009 to September 2015 and beginning primary IAC before the age of 3 months. The patient characteristics, overall outcomes and therapy-related complications were assessed. Results The mean patient age at the first IAC treatment was 10.4 weeks (range 4.9–12.9 weeks). These eyes were classified according to the International Classification of Retinoblastoma (ICRB) as group A (n = 0), B (n = 2), C (n = 0), D (n = 9), or E (n = 2). A total of 28 catheterizations were performed, and the procedure was stopped in one patient because of internal carotid artery spasm. Each eye received a mean of 2.6 cycles of IAC (range 2–4 cycles). After IAC with a mean follow-up of 28.3 months (range 9–65 months), tumor regression was observed in 12 of 13 eyes. One eye was enucleated due to tumor progression. All patients are alive and no patient has developed metastatic disease or other malignancies. Conclusions Our experience suggests IAC as primary therapy is a feasible and promising treatment for retinoblastoma in infants less than 3 months of age.
Improved circular straight cone channel model for high altitude platform in urban environment

To revise the fallacies of the straight circular cone channel model for high altitude platform (HAP), an improved model is proposed by introducing the concept of blockage theory. The improved model successfully revised the wrong delay spread in the straight circular cone channel model and provided the revised delay spread, which is consistent with measured data. The improved model also gives the existing probability of single bounce echoes in three-dimensional space, which is also useful in other analysis of multipath effects. The revised cumulative distribution function, the power spread profile and the coherence bandwidth is obtained by applying the improved model, which proves the new model is more approximate to actual situations and more accurate in the analysis of the channel for HAP.
An Evaluation of Predicate Argument Clustering using Pseudo-Disambiguation

Schulte im Walde et al. (2008) presented a novel approach to semantic verb classication. The predicate argument model (PAC) presented in their paper models selectional preferences by using soft clustering that incorporates the Expectation Maximization (EM) algorithm and the MDL principle. In this paper, I will show how the model handles the task of differentiating between plausible and implau- sible combinations of verbs, subcategorization frames and arguments by applying the pseudo-disambiguation evaluation method. The predicate argument clustering model will be evaluated in comparison with the latent semantic clustering model by Rooth et al. (1999). In particular, the influences of the model parameters, data frequency, and the individual components of the predicate argument model are examined. The results of these experiments show that (i) the selectional preference model overgeneralizes over arguments for the purpose of a pseudo-disambiguation task and that (ii) pseudo-disambiguation should not be used as a universal indicator for the quality of a model.
Basal cytokeratin as a potential marker of low risk of invasion in ductal carcinoma in situ

OBJECTIVES: Biological markers that predict the development of invasive breast cancer are needed to improve personalized therapy for patients diagnosed with ductal carcinoma in situ. We investigated the role of basal cytokeratin 5/6 in the risk of invasion in breast ductal carcinoma in situ. METHODS: We constructed tissue microarrays using 236 ductal carcinoma in situ samples: 90 pure samples (group 1) and 146 samples associated with invasive carcinoma (group 2). Both groups had similar nuclear grades and were obtained from patients of similar ages. The groups were compared in terms of estrogen (ER) and progesterone receptor (PR) status, human epidermal growth factor receptor 2 (HER2) expression, cytokeratin 5/6 immunostaining, human epidermal growth factor receptor 1 (EGFR) membrane staining and molecular subtype, as indicated by their immunohistochemistry profiles. RESULTS: ER/PR-negative status was predictive of invasion, whereas HER2 superexpression and cytokeratin 5/6-positive status were negatively associated with invasion. Among the high-grade ductal carcinoma in situ cases, a triple-positive profile (positive for estrogen receptor, progesterone receptor, and HER2) and cytokeratin 5/6 expression by neoplastic cells were negatively associated with invasion. In the low-grade ductal carcinoma in situ subgroup, only cytokeratin 5/6 expression exhibited a negative association with the probability of invasion. CONCLUSION: The immunohistochemical expression of cytokeratin 5/6 by ductal carcinoma in situ epithelial cells may provide clinically useful information regarding the risk of progression to invasive disease.
Response of RF Networks to Transient Waveforms: Interference in Frequency-Hopped Communications

The long-tail transient responses of a bandpass network to pulsed and switched-tone stimuli are examined and a time-domain closed-form expression of the envelope response is developed. It is shown that the long-tail response leads to interference in frequency-hopping communication systems. Interference, and in particular co-site interference, can result in any radar, communication, or RF sensor system becoming exposed to unintentional pulsed RF signals. In the experimental study, 900-MHz Chebyshev bandpass filters are considered.
Exploring PHD Fingers and H3K4me0 Interactions with Molecular Dynamics Simulations and Binding Free Energy Calculations: AIRE-PHD1, a Comparative Study

PHD fingers represent one of the largest families of epigenetic readers capable of decoding post-translationally modified or unmodified histone H3 tails. Because of their direct involvement in human pathologies they are increasingly considered as a potential therapeutic target. Several PHD/histone-peptide structures have been determined, however relatively little information is available on their dynamics. Studies aiming to characterize the dynamic and energetic determinants driving histone peptide recognition by epigenetic readers would strongly benefit from computational studies. Herein we focus on the dynamic and energetic characterization of the PHD finger subclass specialized in the recognition of histone H3 peptides unmodified in position K4 (H3K4me0). As a case study we focused on the first PHD finger of autoimmune regulator protein (AIRE-PHD1) in complex with H3K4me0. PCA analysis of the covariance matrix of free AIRE-PHD1 highlights the presence of a “flapping” movement, which is blocked in an open conformation upon binding to H3K4me0. Moreover, binding free energy calculations obtained through Molecular Mechanics/Poisson-Boltzmann Surface Area (MM/PBSA) methodology are in good qualitative agreement with experiments and allow dissection of the energetic terms associated with native and alanine mutants of AIRE-PHD1/H3K4me0 complexes. MM/PBSA calculations have also been applied to the energetic analysis of other PHD fingers recognizing H3K4me0. In this case we observe excellent correlation between computed and experimental binding free energies. Overall calculations show that H3K4me0 recognition by PHD fingers relies on compensation of the electrostatic and polar solvation energy terms and is stabilized by non-polar interactions.
ATP alters current fluctuations of cystic fibrosis transmembrane conductance regulator: evidence for a three-state activation mechanism

The cystic fibrosis gene product cystic fibrosis transmembrane conductance regulator (CFTR) is a low conductance, cAMP-regulated Cl- channel. Removal of cytosolic ATP causes a cessation of cAMP-dependent kinase-phosphorylated CFTR channel activity that resumes upon ATP addition. (Anderson, M. P., H. A. Berger, D. R. Rich, R. J. Gregory, A. E. Smith, and M. J. Welsh. 1991. Cell. 67:775-784). The aim of this study was to quantify possible effects of ATP on CFTR gating. We analyzed multichannel records since only 1 of 64 patches contained a single channel. ATP increased the channel open probability (Po) as a simple Michaelis-Menten function of concentration; the effect was half maximal at 24 microM, reached a maximum of 0.44, and had a Hill coefficient of 1.13. Since the maximum Po was not 1, the simplest description of the effect of ATP on CFTR gating is the noncooperative three-state mechanism of del Castillo and Katz (1957. Proceedings of the Royal Society of London. B. 146:369-381). We analyzed current fluctuations to quantify possible changes in CFTR gating. The power density spectra appeared to contain a single Lorentzian in the range of 0.096-31 Hz. Analysis of the corner frequency (fc) of this Lorentzian revealed that ATP increased 2 pi fc as a Michaelis-Menten function with a Hill coefficient of 1.08, and it provided estimates of the ATP dissociation constant (44 tau open (154 ms), and the ATP-sensitive tau close [(185 ms) (44 microM/[ATP] + 1)]. These results suggest that the binding reaction is rapid compared to the opening and closing rates. Assuming that there is a single set of closed-to-open transitions, it is possible to verify the outcome of fluctuation analysis by comparing fluctuation-derived estimates of Po with measures of Po from current records. The two values were nearly identical. Thus, noise analysis provides a quantitative description of the effect of ATP on CFTR opening. The noncooperative three-state model should serve as a basis to understand possible alterations in CFTR gating resulting from regulators or point mutations.
Signal bias removal with orthogonal transform for adverse Mandarin speech recognition

A new method for applying orthogonal transforms in signal bias removal (SBR) for adverse Mandarin speech recognition (MSR) is proposed. The orthogonal transform process is performed in a moving window manner to extract features from the input speech. Codewords are then obtained by matching high-order, bias-free features with pre-trained codebooks for bias estimation. The effectiveness of the method has been confirmed by an experiment involving multi-speaker adverse continuous MSR. Significant improvements in the recognition accuracy and computation time were achieved as compared with the conventional SBR method.