Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term Outcomes of Primary Percutaneous Coronary Intervention with Second-generation Drug-eluting Stents in ST-elevation Myocardial Infarction Patients Caused by Very Late Stent Thrombosis

Background: The ST-segment elevation myocardial infarction (STEMI) patients due to stent thrombosis (ST) remain a therapeutic challenge for a clinician. Till date, very few researches have been conducted regarding the safety and effectiveness of primary percutaneous coronary intervention (PCI) with second-generation drug-eluting stents (DES) for STEMI caused by very late ST (VLST). This retrospective study evaluated the safety, efficacy, and outcomes of primary PCI with second-generation DES for STEMI due to VLST compared with primary PCI for STEMI due to de novo lesion. Methods: Between January 2007 and December 2013, STEMI patients with primary PCI in Fuwai Hospital had only second-generation DES implanted for de novo lesion (558 patients) and VLST (50 patients) were included in this retrospective study. The primary end points included cardiac death and reinfarction. The secondary end points included cardiac death, reinfarction, and target lesion revascularization. Continuous variables were expressed as mean (standard deviation) or median (interquartile range) and compared by Student's t-test or Mann-Whitney U-test as appropriate. Categorical variables were expressed as counts and percentages, and comparison of these variables was performed with Chi-square or Fisher's exact test. A two-tailed value of P < 0.05 was considered statistically significant for all comparisons. Statistical analyses were performed by SAS software (version 9.4, SAS Institute Inc., Cary, USA) for Windows. Results: In-hospital primary end point and the secondary end point were no significant differences between two groups (P = 1.000 and P = 1.000, respectively). No significant differences between two groups were observed according to the long-term primary end point and the secondary end point. Kaplan-Meier survival curves showed no significant difference between the two groups in the primary end point and the secondary end point at 2 years (P = 0.340 and P = 0.243, respectively). According to Cox analysis, female, intra-aortic balloon pump support, and postprocedural thrombolysis in myocardial infarction flow 3 were found to be independent predictors for long-term follow-up. Conclusion: Primary PCI with second-generation DES is a reasonable choice for STEMI patients caused by VLST.
Hepatitis C virus (HCV) status in newborns born to HCV positive women performing intracytoplasmic sperm injection.

BACKGROUND A low risk of HCV vertical transmission has been reported especially in those born to women with viraemia. Intracytoplasmic sperm injection (ICSI) being an assisted reproduction technique includes procedures that may increase risk of transmission. OBJECTIVE To determine the rate of vertical transmission of HCV to newborns born to HCV positive mothers in ICSI cycles. METHODS In a cross-sectional observational study, serum samples have were collected within the first week after birth from newborns of two groups of ICSI cycles females. Group one: 30 women HCV antibody (Ab) positive/HCV RNA negative. Group two: 30 women HCV Ab positive/HCV RNA positive. Newborn sera were subjected to HCV antibody testing, and detection of HCV viral RNA by PCR. RESULTS None of the newborns born to PCR negative females undergoing ICSI cycles showed positive results neither for HCV antibody, or for HCV RNA. Only one out of the 30 newborns born to PCR positive females was positive for HCV antibody and HCV RNA. CONCLUSION HCV vertical transmission in ICSI cycles seemed to be of low incidence in PCR positive women, while in the case of HCV PCR negative/sero-positive women, it appeared to be completely absent. This observation could have an impact on the clinicians' counseling for HCV positive females seeking ICSI.
Optimization of the magnetic potential for α-Fe

A second generation of empirical potentials is produced for α-Fe within the framework of the magnetic potential formalism (Dudarev and Derlet 2005 J. Phys.: Condens. Matter 17 7097). A materials database that, in addition to ab initio-derived point defect formation energies, now includes third-order elastic constant and ab initio-derived string potential data controlling, respectively, the thermal expansion properties and the core structure of the 1/2⟨111⟩ screw dislocation. Three parameterizations are presented in detail, all of which exhibit positive thermal expansion and produce a non-degenerate configuration for the relaxed 1/2⟨111⟩ screw dislocation easy core structure. These potentials, along with two other published potentials, are investigated in terms of defect formation volume, early stage dislocation loop clustering energetics, ⟨110⟩ dumbbell interstitial diffusion, and the zero-stress 1/2⟨111⟩ screw dislocation Peierls barrier and its corresponding kink formation energies.
The aftermath of the intermediate value theorem

The solvability of nonlinear equations has awakened great interest among mathematicians for a number of centuries, perhaps as early as the Babylonian culture (3000-300 B.C.E.). However, we intend to bring to our attention that some of the problems studied nowadays appear to be amazingly related to the time of Bolzano's era (1781-1848). Indeed, this Czech mathematician or perhaps philosopher has rigorously proven what is known today as the intermediate value theorem, a result that is intimately related to various classical theorems that will be discussed throughout this work.
Parental Attachment, School Attachment and Life Satisfaction in Early Adolescence

This study examined the relationships between parental attachments, school attachments and life satisfaction, and whether school attachment served as a mediator between parental attachment and life satisfaction in a sample of early adolescents (n= 153; mean age= 12.71 years). Results indicated that both maternal and paternal attachment positively related to life satisfaction; among the school attachment dimensions only attachment to teacher associated with life satisfaction of adolescents. Hierarchical regression analyses provided evidence that school attachment partially mediated the link between parental attachment and life satisfaction for both maternal and paternal models. Implications for intervention programs are discussed.
AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster

Clathrin adaptor protein complex-1 (AP-1) and its accessory proteins play a role in the sorting of integral membrane proteins at the trans-Golgi network and endosomes. Their physiological functions in complex organisms, however, are not fully understood. In this study, we found that CG8538p, an uncharacterized Drosophila protein, shares significant structural and functional characteristics with Aftiphilin, a mammalian AP-1 accessory protein. The Drosophila Aftiphilin was shown to interact directly with the ear domain of γ-adaptin of Drosophila AP-1, but not with the GAE domain of Drosophila GGA. In S2 cells, Drosophila Aftiphilin and AP-1 formed a complex and colocalized at the Golgi compartment. Moreover, tissue-specific depletion of AP-1 or Aftiphilin in the developing eyes resulted in a disordered alignment of photoreceptor neurons in larval stage and roughened eyes with aberrant ommatidia in adult flies. Furthermore, AP-1-depleted photoreceptor neurons showed an intracellular accumulation of a Notch regulator, Scabrous, and downregulation of Notch by promoting its degradation in the lysosomes. These results suggest that AP-1 and Aftiphilin are cooperatively involved in the intracellular trafficking of Notch during eye development in Drosophila.
Performance constraints and vocal complexity in birdsong: Evidence from a vocal mimic

The diverse vocal performances of oscine songbirds are produced by coordinated patterns of activity in muscles controlling separate sound generators on the right and left sides of their duplex vocal organ, the syrinx. But how do songbirds use these two sound sources to produce their acoustically and temporally complex vocal communication signals? I used northern mockingbirds (Mimus polyglottos) as a model species to investigate peripheral sources of vocal complexity, and to test hypotheses about putative constraints on vocal production. In these experiments, I show that when a vocal mimic accurately copies the song of another species it must also use the same vocal motor pattern employed by the model species. Vocal motor “mistakes” or deviations from the stereotyped motor patterns associated with the most acoustically similar mimicries of each sound type, resulted in predictable deviations from accurate copies of tutor sounds. I present physiological evidence supporting previous hypotheses for mechanical and acoustic coupling between the two sides of the syrinx. Mockingbird mimicries of synthesized tutor sounds designed to test the ability of the two sides of the syrinx to simultaneously generate different sounds, reveal that although the two sides of the syrinx are theoretically independent, there are significant constraints on how different the contribution from the two sides can be. Finally, I found that nonlinear dynamics within the syrinx can give rise to phenomena such as subharmonics, frequency jumps, biphonation and chaos that further increase the acoustic complexity of mockingbird song. By identifying the features of song most difficult for mockingbirds to produce, we can gain insights into the physical and physiological limitations on song production and further the understanding of the types of selective forces that may drive the evolution of vocal communication signals.
Design of Amperometric Biosensors and Biofuel Cells by the Reconstitution of Electrically Contacted Enzyme Electrodes

The electrical contacting of redox enzymes with electrodes is the most fundamental requirement for the development of amperometric biosensors and biofuel cell elements. For the effective electrical communication of redox enzymes with electrodes the use of electron relay units that transport the electrons between the enzyme redox center and the conducting surface is essential. Also, the structural alignment of the redox enzyme units in respect to the electrode in a configuration where the enzyme redox center is in close proximity to the conductive surface is needed. The present report summarizes the reconstitution paradigm developed by our laboratory in the last decade as a versatile method to electrically contact redox enzymes with electrodes, and as a generic approach to develop amperometric biosensors and biofuel cell elements. The process is based on the reconstitution of the apo-enzyme on a relay-cofactor monolayer on thin film-functionalized electrode. Different relay units were used to electrically communicate flavin adenine dinucleotide (FAD)-containing enzymes (flavoenzymes) or pyrroloquinoline quinone (PQQ)-containing enzymes with electrodes. This included molecular redox-active relays, molecular redox-active ‘shuttles’, redox-active polymers (e.g., polyaniline), Au nanoparticles, and carbon nanotubes. The reconstitution of different apo-enzymes on these relay-cofactor-functionalized electrodes led to unprecedented efficient electrical contacting between the redox centers of the enzymes and the electrodes. Besides very sensitive amperometric biosensors that emerged from this method, the resulting amperometric biosensors revealed high selectivity and specificity. A related approach to establish electrical contact between redox enzymes dependent on diffusional cofactors and electrodes and to develop an integrated bioelectrocatalytically active enzyme electrode was developed. The method involved assembly of a relay-cofactor diad on the electrode, and the surface crosslinking of an affinity complex generated between the enzyme and the surface-confined cofactor units. This method was successfully applied to electrically contact nicotinamide adenine dinucleotide (phosphate) NAD(P)+-dependent enzymes and cytochrome c-dependent enzymes. For example, enzyme-modified electrodes for the bioelectrocatalyzed oxidation of alcohol, lactate and malate were fabricated by the electrical contacting of the respective NAD(P)+-dependent dehydrogenases. Similarly, the bioelectrocatalytic reduction of O2 was accomplished by an integrated cytochrome c/cytochrome oxidase-functionalized electrode. The electrically contacted enzyme electrodes were also used to develop noncompartmentalized biofuel cell elements. Biofuel cell elements consisting of electrically contacted reconstituted enzyme electrodes were constructed. Glucose or alcohol were used in these systems as fuel substrates and O2 as oxidizer.
Amyloid Beta‐Induced Neuronal Death is Bax‐Dependent but Caspase‐Independent

Fibrillar amyloid beta (Aβ) peptides are major constituents of senile plaques in Alzheimer disease (AD) brain and cause neuronal apoptosis in vitro. Bax and caspase-3 have been implicated in the pathogenesis of AD and are components of a well-defined molecular pathway of neuronal apoptosis. To determine whether Aβ-induced neuronal apoptosis involves bax and/or caspase-3 activation, we examined the effect of Aβ on wild-type, bax-deficient, and caspase-3-deficient telencephalic neurons in vitro. In wild-type cultures, Aβ produced time- and concentration-dependent caspase-3 activation, apoptotic nuclear changes, and neuronal death. These neurotoxic effects of Aβ were not observed in bax-deficient cultures. Caspase-3 deficiency, or pharmacological inhibition of caspase activity, prevented caspase-3 activation and blocked the appearance of apoptotic nuclear features but not Aβ-induced neuronal death. Neither calpain inhibition nor microtubule stabilization with Taxol protected telencephalic neurons from Aβ-induced caspase activation or apoptosis. These results have potential implications regarding the underlying pathophysiology of AD and towards AD treatment strategies.
Long life solid-state RF powered light sources for projection display and general lighting applications.

solid-state RF powered electrodeless light source is presented that has high luminous output and long life, having achieved over 16,000 hours of continuous operation at better than 90% of initial output. The lamp operates around 900 MHz using 160 W of RF power at 65% efficiency. The lamp uses a silicon LDMOS power amplifier in a high-power oscillator configuration, and it converts microwaves into light energy using a novel waveguide cavity resonator to couple power into the bulb. The lamp light spectrum is broadband, and similar to sunlight with CRI≫90. This achievement marks the first ever successful commercialization and mass production of electrodeless light source technology for consumer applications. These lamps have been in volume production at over 10,000 units/month for use in microdisplay-based rear projection televisions, and conform to various reliability standards, including UL and FCC requirements.
Retrieving geo-location of videos with a divide & conquer hierarchical multimodal approach

This paper presents a strategy to identify the geographic location of videos. First, it relies on a multi-modal cascade pipeline that exploits the available sources of information, namely the user's upload history, his social network and a visual-based matching technique. Second, we present a novel divide & conquer strategy to better exploit the tags associated with the input video. It pre-selects one or several geographic area of interest of higher expected relevance and performs a deeper analysis inside the selected area(s) to return the coordinates most likely to be related to the input tags. The experiments were conducted as part of the MediaEval 2012 Placing Task. Our approach, which differs significantly from the other submitted techniques, achieves the best results on this benchmark when considering the same amount of external information, i.e. when not using any gazetteers nor any other kind of external information.
Image Clustering under Domain Shift

We address domain adaptation in the context of clustering where we are given a set of unlabeled data, coming from several domains, and the goal is to group data into different categories regardless of the domain they come from. This is a challenging problem since we do not have any supervision unlike most adaptation scenarios studied earlier, and is very relevant in practical industry applications where labeled data often comes at a premium especially while deploying services that do not have a comparable predecessor. Our philosophy in addressing this problem draws motivation from the concept of dirty paper coding, a communications technique where the signal being transmitted through a noisy channel is encoded with priors on the possible noise patterns to assist reliable decoding of the signal at the receiver. We focus on image applications in this paper, where we encode priors on possible image domain shift factors such as viewpoint, lighting, blur and appearance variations and utilize geometric adaptation mechanisms to perform clustering. We illustrate the utility of our approach on standard datasets involving objects and faces, by obtaining around 18% improvement on average over existing approaches.
A Short Analysis of Discourse Coherence

As an essential element of discourse, coherence has been the focus of study for several decades. Previous researches mainly view discourse coherence as a static product and explore it on linguistic level. However, it is also a dynamic process and can be achieved by the cooperation made by the discourse producer and receiver based on their mutual understanding. It involves both linguistic and non-linguistic factors. In this article, the author reviews previous researches on discourse coherence and presents the nature of discourse coherence from cognitive perspective, aiming at giving an insight into discourse comprehension and teaching.
Cancer hyperthermia using magnetic nanoparticles

Magnetic‐nanoparticle‐mediated intracellular hyperthermia has the potential to achieve localized tumor heating without any side effects. The technique consists of targeting magnetic nanoparticles to tumor tissue followed by application of an external alternating magnetic field that induces heat through Néel relaxation loss of the magnetic nanoparticles. The temperature in tumor tissue is increased to above 43°C, which causes necrosis of cancer cells, but does not damage surrounding normal tissue. Among magnetic nanoparticles available, magnetite has been extensively studied. Recent years have seen remarkable advances in magnetite‐nanoparticle‐mediated hyperthermia; both functional magnetite nanoparticles and alternating‐magnetic‐field generators have been developed. In addition to the expected tumor cell death, hyperthermia treatment has also induced unexpected biological responses, such as tumor‐specific immune responses as a result of heat‐shock protein expression. These results suggest that hyperthermia is able to kill not only local tumors exposed to heat treatment, but also tumors at distant sites, including metastatic cancer cells. Currently, several research centers have begun clinical trials with promising results, suggesting that the time may have come for clinical applications. This review describes recent advances in magnetite nanoparticle‐mediated hyperthermia.
The Role of Emotional Relational Behaviors on Interpersonal Consumer Service Loyalty

This study seeks to examine factors that enhance the development of interpersonal service relationships between consumers and service employees. It focuses on interpersonal service relationships that are extended in duration, affective or emotionally charged, and intimate in distance (EAI), or those which appear to be boundary open (Price and Arnould 1999; Price et al. 1995a, 1995b). It thus emphasizes relationships that are similar to personal acquaintances and friendships, rather than ones that are non-affective, and consist of little or no emotional content, such as professional relationships and casual acquaintances (Johnson and Selnes 2004; Coulter and Ligas 2004). Based on a review of the literature, five factors, namely, mutual understanding, personalization, authenticity, problem-solving behavior, and specialized treatment, are combined to form a parsimonious group of relational behaviors (RBs) that are expected to promote friendship-like relationships. A conceptual model is portrayed that shows interrelationships between the relational behaviors and relationship outcomes, including service quality, satisfaction, emotional trust, and loyalty (Sirdeshmukh et al. 2002). In order to collect data, this study utilizes a self-report survey and crosssectional design, within the context of hair care service. Additionally, web-based survey and sampling are utilized. The sample consists of individuals who are
Validation Study: Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro

Background In a previous publication we introduced a novel approach to identify genes that hold predictive information about treatment outcome. A linear regression model was fitted by using the least angle regression algorithm (LARS) with the expression profiles of a construction set of 18 glioma progenitor cells enhanced for brain tumor initiating cells (BTIC) before and after in vitro treatment with the tyrosine kinase inhibitor Sunitinib. Profiles from treated progenitor cells allowed predicting therapy-induced impairment of proliferation in vitro. Prediction performance was validated in leave one out cross validation. Methods In this study, we used an additional validation set of 18 serum-free short-term treated in vitro cell cultures to test the predictive properties of the signature in an independent cohort. We assessed proliferation rates together with transcriptome-wide expression profiles after Sunitinib treatment of each individual cell culture, following the methods of the previous publication. Results We confirmed treatment-induced expression changes in our validation set, but our signature failed to predict proliferation inhibition. Neither re-calculation of the combined dataset with all 36 BTIC cultures nor separation of samples into TCGA subclasses did generate a proliferation prediction. Conclusion Although the gene signature published from our construction set exhibited good prediction accuracy in cross validation, we were not able to validate the signature in an independent validation data set. Reasons could be regression to the mean, the moderate numbers of samples, or too low differences in the response to proliferation inhibition in the validation set. At this stage and based on the presented results, we conclude that the signature does not warrant further developmental steps towards clinical application.
Uncertainty Representation Method for Open Pit Optimization Results Due to Variation in Mineral Prices

This study proposes a new method to quantitatively represent the uncertainty existing in open pit optimization results due to variations in mineral prices. After generating multiple mineral prices using Monte Carlo simulation with data on past mineral prices, a probability model that represents the uncertainty was developed by integrating multiple open pit optimization results derived from the mineral prices. The results of applying the proposed method to the copper-zinc deposits showed that significant uncertainty exists in open pit optimization results due to the variation in copper prices. It was also found that the method has a potential as a tool for classifying the estimation results of ore reserve based on confidence level.