Miracle-dz/UniFAR-FTUs huggingface dataset:
Results of a large retrospective analysis of the effect of intended dose intensity of R‐CHOP on outcome in a cohort of consecutive, unselected elderly patients with de novo diffuse large B cell lymphoma

showed that uric acid levels were similar in samples sent to the laboratory on ice to those measured at room temperature immediately after sampling. A 1-h transport delay resulted in a 20% reduction in uric acid levels. Given that our guideline recommends a de-escalation in rasburicase dose and duration of therapy, particularly for adults, we believe it is sensible to exercise caution in uric acid monitoring, thus avoiding the risk of falsely low levels inappropriately guiding therapy. Ayed et al suggest that a strategy of ‘preventive’ admission to intensive care units is warranted if patients are considered at risk of TLS development. They also suggest that fluid and electrolyte management will be improved by admission to intensive care. Whilst this may well be the case for some patients, such as those with pre-existing cardiac or renal dysfunction for example, it is unlikely to improve outcome for all at-risk patients. We agree that patients transferred to intensive care without significant organ failure do better than those transferred once organ failure has developed (Hampshire et al, 2009). We also agree, as stated in the guideline, that close team working between haematologists, intensive care specialists and nephrologists is central to the management of TLS. We advocate proactive transfer of high-risk patients into haematology units where appropriate intensive care facilities are available, if intensive care input is not available locally. Once patients are being managed in a haematology facility offering the appropriate level of care (Matthey et al, 2010), we would suggest the use of the National Early Warning Score, a ‘track and trigger’ tool derived from the monitoring of physiological variables (Royal College of Physicians, 2012), along with frequent biochemical monitoring to allow early recognition of the deteriorating patient. Such track and trigger systems have been shown to increase early referrals to intensive care though their impact on survival remains unclear. Clearly, there are likely to be international differences in the use of intensive care facilities and in patient selection criteria for intensive care admission. These BCSH guidelines were inevitably written from a UK standpoint; modifications are likely to be required if they are to be applied in other healthcare settings.
Bronchoalveolar Lavage Fluid Cytology in Patients with Pneumocystis carinii Pneumonia

OBJECTIVE To evaluate bronchoalveolar lavage (BAL) cytology and organism burden in patients with Pneumocystis carinii pneumonia (PCP) who were infected with the human immunodeficiency virus (HIV) and in those with other immunodeficiencies. STUDY DESIGN BAL fluid samples from patients with PCP were selected (HIV-infected patients, n = 15; patients with other immunodeficiencies, n = 11). May-Grünwald-Giemsa-stained cytocentrifuge preparations were evaluated. Foamy alveolar casts (FACs) and P carinii clusters were counted. RESULTS The numbers of FACs and P carinii clusters in BAL fluid samples of HIV-infected patients were significantly higher as compared to those in samples from patients with other immunodeficiencies. Striking cytologic findings observed in half the samples from both patient groups included the presence of foamy alveolar macrophages, activated lymphocytes, plasma cells and reactive type II pneumocytes. Furthermore, a peculiar cell type, "nonidentified cell" (NIC), was observed almost exclusively in BAL fluid samples from HIV-infected patients. CONCLUSION BAL fluid samples from HIV-infected patients with PCP displayed higher organism burdens as compared to those from patients with other immunodeficiencies. Moreover, cytologic findings suggestive of noninfectious lung conditions were common in BAL fluid samples obtained from patients with PCP. Further study is required to elucidate the identity of the NIC cell type.
LecRK‐V, an L‐type lectin receptor kinase in Haynaldia villosa, plays positive role in resistance to wheat powdery mildew

Summary Plant sense potential microbial pathogen using pattern recognition receptors (PRRs) to recognize pathogen‐associated molecular patterns (PAMPs). The Lectin receptor‐like kinase genes (LecRKs) are involved in various cellular processes mediated by signal transduction pathways. In the present study, an L‐type lectin receptor kinase gene LecRK‐V was cloned from Haynaldia villosa, a diploid wheat relative which is highly resistant to powdery mildew. The expression of LecRK‐V was rapidly up‐regulated by Bgt inoculation and chitin treatment. Its transcript level was higher in the leaves than in roots, culms, spikes and callus. Single‐cell transient overexpression of LecRK‐V led to decreased haustorium index in wheat variety Yangmai158, which is powdery mildew susceptible. Stable transformation LecRK‐V into Yangmai158 significantly enhanced the powdery mildew resistance at both seedling and adult stages. At seedling stage, the transgenic line was highly resistance to 18 of the tested 23 Bgt isolates, hypersensitive responses (HR) were observed for 22 Bgt isolates, and more ROS at the Bgt infection sites was accumulated. These indicated that LecRK‐V confers broad‐spectrum resistance to powdery mildew, and ROS and SA pathways contribute to the enhanced powdery mildew resistance in wheat.
Lightweight Concrete Modification Factor for Shear Friction

This report describes the results of a study initiated to examine the influence of concrete unit weight on the direct shear transfer across an interface of concretes cast at different times. This type of interface is common with structural precast concrete connections, such as corbels, for which shear friction design provisions are commonly used. Increasing use of lightweight aggregate concretes prompted this investigation to determine the appropriateness of current shear friction design provisions with respect to all-lightweight and sand-lightweight concrete. The experimental investigation included 36 push-off test specimens, each of which was constructed with a cold-joint at the interface shear plane. Test variables included unit weight of concrete (108, 120, and 145 pcf), target compressive strength of concrete (5000 and 8000 psi), and interface condition (smooth or roughened). A constant amount of reinforcing steel was provided across the shear plane. Results suggest that concrete unit weight did not play a significant role in the interface shear strength for the cold-joint specimens in this study. Results were also compared with shear friction design provisions in both the ACI 318 code and the PCI Design Handbook. Shear strengths computed using the coefficient of friction µ approach were conservative for the sand-lightweight and all-lightweight cold-joint specimens in this study. The value of the effective coefficient of friction µₑ computed using the PCI Design Handbook approach was found to be conservative for both roughened and smooth non-monolithic interfaces for each concrete type. Finally, the use of the lightweight concrete modification factor in the calculation for the effective coefficient of friction µₑ was found to be conservative for the sand-lightweight and all-lightweight cold-joint specimens in this study.
Fluorescence in situ hybridization for detecting erbB-2 amplification in breast tumor fine needle aspiration biopsies.

OBJECTIVE To evaluate the feasibility of erbB-2 amplification analysis of fine needle aspiration (FNA) biopsies. STUDY DESIGN FNA smears and dissociated nuclei from 58 breast cancer samples were examined by dual-labeling fluorescence in situ hybridization (FISH) with probes for centromere 17 and the erbB-2 gene. The results were compared with the outcome of erbB-2 immunohistochemistry. RESULTS Tumors were categorized according to the erbB-2/centromere 17 signal ratio. There were 23 tumors with high-level amplification, four cases with a low-level erbB-2 gain and 27 tumors with normal erbB-2 content. Four tumors showed an erbB-2 deletion, all in patients < or = 42 years of age. ErbB-2 amplification was strongly associated with positive erbB-2 immunostaining (P < .0001). Comparison of FISH analysis on dissociated cells and on FNA biopsies showed high correspondence (P < .0001). CONCLUSION FISH allows reliable detection of erbB-2 gene amplification on FNA biopsies.
Resting state functional magnetic resonance imaging processing techniques in stroke studies

Abstract In recent years, there has been considerable research interest in the study of brain connectivity using the resting state functional magnetic resonance imaging (rsfMRI). Studies have explored the brain networks and connection between different brain regions. These studies have revealed interesting new findings about the brain mapping as well as important new insights in the overall organization of functional communication in the brain network. In this paper, after a general discussion of brain networks and connectivity imaging, the brain connectivity and resting state networks are described with a focus on rsfMRI imaging in stroke studies. Then, techniques for preprocessing of the rsfMRI for stroke patients are reviewed, followed by brain connectivity processing techniques. Recent research on brain connectivity using rsfMRI is reviewed with an emphasis on stroke studies. The authors hope this paper generates further interest in this emerging area of computational neuroscience with potential applications in rehabilitation of stroke patients.
Neural Network–Assisted Analysis and Microscopic Rescreening in Presumed Negative Cervical Cytologic Smears

OBJECTIVE To compare cytologists' detection of abnormalities when using neural network-assisted (NNA) review, as employed by the PAPNET Testing System and to compare the effectiveness of this mode of review to that of unassisted, conventional rescreening of cervical smears initially diagnosed as negative. STUDY DESIGN The study was undertaken as part of a multicenter clinical trial involving over 10,000 smears from 10 investigation sites (9 academic institutions and 1 private laboratory). Using a subset of "negative" control smears from three university laboratories, the false negative detection yields of NNA review (performed using the PAPNET System) and conventional microscopic rescreening (performed as part of routine quality control practice) were compared. The false negative detection yield was defined as the percentage of rescreened negatives reclassified as abnormal. RESULTS The results demonstrate that using NNA review, the detection yield of false negative smears, as a proportion of negative smears reexamined, is statistically significantly greater than that obtained using conventional quality control rescreening. The false negative yield generated using NNA analysis was 6.2% (142/2293) versus 0.6% (82/13761) for conventional rescreening. A statistically significant improvement in identification of abnormality is observed for NNA review as opposed to unassisted rescreening despite constraining the comparison in the following ways: (1) comparing the yields of rescreening of negative smears obtained from the same time intervals for both methods, (2) comparing the yields of rescreening of negative smears obtained from the years after the Clinical Laboratory Improvement Act (1990 and 1991) for both methods, and (3) disregarding the identification of atypical squamous cells of undetermined significance/atypical glandular cells of undetermined significance cases and comparing only the identification of squamous intraepithelial lesions using the two methods. CONCLUSION Using neural network-assisted review, cytologists uncovered a significantly higher proportion of previously undetected cervical abnormalities per smear reexamined than they did using unassisted, conventional rescreening.
Characterization of the Integrated Lens Antenna at Terahertz Frequencies

Results of beam pattern and polarization measurements on quasioptical integrated lens antennae at terahertz frequencies are presented. The integrated antenna consists of a planar spiral antenna mounted on the flat surface of an extended hemispherical lens. The planar antenna used is an equiangular logarithmic spiral, which comprises 1.5 turns with a spiral expansion rate of 3.2 per turn. The RF bandwidth of the antenna is designed to 0.3-2.5 THz. We have investigated the optical performance of such an integrated antenna and observed that the polarization is changing from almost circular at frequencies below 1.4 THz to elliptical with an axial ratio equal to 3 at 2.5 THz. The beam patterns have been measured up to 2.5 THz for two orthogonal polarization directions aligned with the elliptical polarization axes. The main lobes are primarily diffraction limited by the aperture of the lens. The first order sidelobe level equals -16 dB at 0.6 THz and increases to –8-12 dB at 1.4 THz and -7-10 dB at 2.5 THz.
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A polymer [Pd(CH2SO2C6H4Me)2]n is obtained by thermolysis of cis-[Pd(CH2SO2C6H4Me)2(NCMe)2] to release the MeCN ligands. The corresponding coordination sites are then occupied by weak Pd–O bonds, easier to break than the previous Pd–N bonds. This allows to produce from the polymer cis complexes containing ligands weaker than NCMe, such as acetone or water. The complexes (cis-[Pd(CH2SO2C6H4Me)2{OC(CD3)2}2], cis-[Pd(CH2SO2C6H4Me)2(OH2)2], cis[Pd(CH2SO2C6H4Me)2(OH2){OC(CD3)2}], and cyclic dimers [Pd(CH2SO2C6H4Me)2(OH2)]2 with bridging methylsulphone groups are formed. The Pd:PPh3:OH2 1:1:1 reaction of the polymer produces cis-[Pd(CH2SO2C6H4Me)2(PPh3)(OH2)], which isomerizes to trans-[Pd(CH2SO2C6H4Me)2(PPh3)(OH2)], with water O-coordinated to Pd and making hydrogen bonds to the two SO2 groups as seen in its X-ray structure. A similar role is played by RNH2 groups in the structures of trans[Pd(CH2SO2C6H4Me)2(PPh3)(NH3)] and the dimer μ-(N2H4)(trans-[Pd(CH2SO2C6H4Me)2(PPh3)])2. In addition to these interesting intramolecular hydrogen bonding properties provided by the SO2 groups, the structural and H NMR data available suggest that the CH2SO2C6H4Me group is an interesting kind of alkyl strongly σ donor, with high trans influence, and forming very stable Pd complexes extraordinarily reluctant to reductive elimination and to hydrolysis by water at room temperature.
Development of a parent‐reported questionnaire evaluating upper limb activity limitation in children with cerebral palsy

Abstract Background and purpose Upper limb activity measures for children with cerebral palsy have a number of limitations, for example, lack of validity and poor responsiveness. To overcome these limitations, we developed the Children's Arm Rehabilitation Measure (ChARM), a parent‐reported questionnaire validated for children with cerebral palsy aged 5–16 years. This paper describes both the development of the ChARM items and response categories and its psychometric testing and further refinement using the Rasch measurement model. Methods To generate valid items for the ChARM, we collected goals of therapy specifically developed by therapists, children with cerebral palsy, and their parents for improving activity limitation of the upper limb. The activities, which were the focus of these goals, formed the basis for the items. Therapists typically break an activity into natural stages for the purpose of improving activity performance, and these natural orders of achievement formed each item's response options. Items underwent face validity testing with health care professionals, parents of children with cerebral palsy, academics, and lay persons. A Rasch analysis was performed on ChARM questionnaires completed by the parents of 170 children with cerebral palsy from 12 hospital paediatric services. The ChARM was amended, and the procedure repeated on 148 ChARMs (from children's mean age: 10 years and 1 month; range: 4 years and 8 months to 16 years and 11 months; 85 males; Manual Ability Classification System Levels I = 9, II = 26, III = 48, IV = 45, and V = 18). Results The final 19‐item unidimensional questionnaire displayed fit to the Rasch model (chi‐square p = .18), excellent reliability (person separation index = 0.95, α = 0.95), and no floor or ceiling effects. Items showed no response bias for gender, distribution of impairment, age, or learning disability. Discussion The ChARM is a psychometrically sound measure of upper limb activity validated for children with cerebral palsy aged 5–16 years. The ChARM is freely available for use to clinicians and nonprofit organisations.
The Benefit of Attention-to-Memory Depends on the Interplay of Memory Capacity and Memory Load

Humans can be cued to attend to an item in memory, which facilitates and enhances the perceptual precision in recalling this item. Here, we demonstrate that this facilitating effect of attention-to-memory hinges on the overall degree of memory load. The benefit an individual draws from attention-to-memory depends on her overall working memory performance, measured as sensitivity (d′) in a retroactive cue (retro-cue) pitch discrimination task. While listeners maintained 2, 4, or 6 auditory syllables in memory, we provided valid or neutral retro-cues to direct listeners’ attention to one, to-be-probed syllable in memory. Participants’ overall memory performance (i.e., perceptual sensitivity d′) was relatively unaffected by the presence of valid retro-cues across memory loads. However, a more fine-grained analysis using psychophysical modeling shows that valid retro-cues elicited faster pitch-change judgments and improved perceptual precision. Importantly, as memory load increased, listeners’ overall working memory performance correlated with inter-individual differences in the degree to which precision improved (r = 0.39, p = 0.029). Under high load, individuals with low working memory profited least from attention-to-memory. Our results demonstrate that retrospective attention enhances perceptual precision of attended items in memory but listeners’ optimal use of informative cues depends on their overall memory abilities.
The Moderating Effect of Self-Reported State and Trait Anxiety on the Late Positive Potential to Emotional Faces in 6–11-Year-Old Children

Introduction: The emergence of anxiety during childhood is accompanied by the development of attentional biases to threat. However, the neural mechanisms underlying these biases are poorly understood. In addition, previous research has not examined whether state and trait anxiety are independently associated with threat-related biases. Methods: We compared ERP waveforms during the processing of emotional faces in a population sample of 58 6–11-year-olds who completed self-reported measures of trait and state anxiety and depression. Results: The results showed that the P1 was larger to angry than neutral faces in the left hemisphere, though early components (P1, N170) were not strongly associated with child anxiety or depression. In contrast, Late Positive Potential (LPP) amplitudes to angry (vs. neutral) faces were significantly and positively associated with symptoms of anxiety/depression. In addition, the difference between LPPs for angry (vs. neutral) faces was independently associated with state and trait anxiety symptoms. Discussion: The results showed that neural responses to facial emotion in children with elevated symptoms of anxiety and depression were most evident at later processing stages characterized as evaluative and effortful. The findings support cognitive models of threat perception in anxiety and indicate that trait elements of anxiety and more transitory fluctuations in anxious affect are important in understanding individual variation in the neural response to threat in late childhood.
A six-year grazing exclusion changed plant species diversity of a Stipa breviflora desert steppe community, northern China

Excluding grazers is one of most efficient ways to restore degraded grasslands in desert-steppe communities, but may negatively affect the recovery of plant species diversity. However, diversity differences between grazed and fenced grasslands in desert-steppe are poorly known. In a Stipa breviflora desert steppe community in Northern China, we established six plots to examine spatial patterns of plant species diversity under grazed and fenced conditions, respectively. We addressed three aspects of species diversity: (1) The logistic, exponential and power models were used to describe the species-area curve (SAR). Species richness, abundance and Shannon diversity values change differently with increasing sampling areas inside and outside of the fence. The best fitted model for SAR was the logistic model. Excluding grazers had a significant impact on the shape of SAR. (2) Variograms was applied to examine the spatial characteristics of plant species diversity. We found strong spatial autocorrelations in the diversity variables both inside and outside the fence. After grazing exclusion, the spatial heterogeneity decreased in species richness, increased in abundance and did not change in Shannon diversity. (3) We used variance partitioning to determine the relative contributions of spatial and environmental factors to plant species diversity patterns. Environmental factors explained the largest proportion of variation in species diversity, while spatial factors contributed little. Our results suggest that grazing enclosures decreased species diversity patterns and the spatial pattern of the S. breviflora desert steppe community was predictable.
Inter-dependent Categorization of Voices and Segments

Listeners performed speeded two-alternative choice between two unfamiliar and relatively similar voices or between two phonetically close segments, in VC syllables. For each decision type (segment, voice), the non-target dimension (voice, segment) either was constant, or varied across four alternatives. Responses were always slower when a non-target dimension varied than when it did not, but the effect of phonetic variation on voice identity decision was stronger than that of voice variation on phonetic identity decision. Cues to voice and segment identity in speech are processed inter-dependently, but hard categorization decisions about voices draw on, and are hence sensitive to, segmental information.
Characterization of Transcription Factor Gene OsDRAP1 Conferring Drought Tolerance in Rice

HIGHLIGHTS Overexpressing and RNA interfering OsDRAP1 transgenic rice plants exhibited significantly improved and reduced drought tolerance, but accompanied with negative effects on development and yield. The dehydration responsive element binding (DREBs) genes are important transcription factors which play a crucial role in plant abiotic stress tolerances. In this study, we functionally characterized a DREB2-like gene, OsDRAP1 conferring drought tolerance (DT) in rice. OsDRAP1, containing many cis-elements in its promoter region, was expressed in all organs (mainly expressed in vascular tissues) of rice, and induced by a variety of environmental stresses and plant hormones. Overexpressing OsDRAP1 transgenic plants exhibited significantly improved DT; while OsDRAP1 RNA interfering plants exhibited significantly reduced DT which also accompanied with significant negative effects on development and yield. Overexpression of OsDRAP1 has a positive impact on maintaining water balance, redox homeostasis and vascular development in transgenic rice plants under drought stress. OsDRAP1 interacted with many genes/proteins and could activate many downstream DT related genes, including important transcription factors such as OsCBSX3 to response drought stress, indicating the OsDRAP1-mediated pathways for DT involve complex genes networks. All these results provide a basis for further complete understanding of the OsDRAP1 mediated gene networks and their related phenotypic effects.