Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental Study of Debonded Sandwich Panels under Compressive Loading

An experimental study of the in-plane compression failure of sandwich panels consisting of glass/epoxy face sheets over a range of PVC foam cores (H45, H100, and H200) and a balsa wood core containing one or two circular or square interfacial debonds is conducted. For the great majority of the specimens, failure occurred by local buckling of the debonded face sheet followed by rapid debond growth towards the panel edges, perpendicular to the applied load. Panels with the largest debond (10 cm diameter or 9 cm length) displayed some post-buckling strength. Examination of the face and core failure surfaces after total separation showed that the tendency for interface (core/resin) failure increases with increasing core density. It was found that the compression strength strongly decreases with decreasing core stiffness and increasing debond size. The compression strength of panels with H45 core decreased with reduced core thickness. Failure loads for panels with symmetric debonds at both face/core interfaces were practically the same as those for panels containing a single debond. Panels with square debonds failed at lower loads than those with circular debonds of the same area. Circular debonds of 50 mm diameter and square debonds of 45 mm length set the threshold for debond failure of the panels considered here.
Impact of bevacizumab (BEV) on efficacy of second-line chemotherapy (CT) for triple-negative breast cancer (TNBC): Analysis of RIBBON-2.

1010 Background: The efficacy of first-line BEV-containing therapy for metastatic breast cancer (MBC) has been proven in three randomized trials. BEV combined with CT resulted in longer progression-free survival (PFS, primary endpoint) and higher objective response rates (RRs) than with CT alone. In the second-line MBC setting, the RIBBON-2 trial demonstrated significantly improved PFS in patients (pts) receiving BEV combined with CT vs CT alone. We present a prespecified analysis of subgroup data in pts with TNBC. METHODS RIBBON-2 enrolled pts with MBC that had progressed on first-line non-BEV-containing CT. After CT was selected from a prespecified list (taxane, gemcitabine, capecitabine, or vinorelbine), pts were randomized 2:1 to receive CT with either BEV (10 mg/kg q2w or 15 mg/kg q3w) or placebo. Crossover to BEV at progression was permitted. The primary endpoint was PFS. RESULTS Of 684 pts treated in RIBBON-2, 159 (23%) had TNBC. Baseline characteristics were reasonably balanced in the two treatment groups. Baseline characteristics and efficacy results are summarized below. CONCLUSIONS Pts with TNBC derive significant RR and PFS benefit from the combination of BEV with second-line CT. Despite the small sample size, there was a trend (HR 0.624; p=0.0534) towards OS benefit. Larger prospective randomized trials of BEV in TNBC are ongoing. [Table: see text].
DTDs versus XML schema: a practical study

Among the various proposals answering the shortcomings of Document Type Definitions (DTDs), XML Schema is the most widely used. Although DTDs and XML Schema Definitions (XSDs) differ syntactically, they are still quite related on an abstract level. Indeed, freed from all syntactic sugar, XML Schemas can be seen as an extension of DTDs with a restricted form of specialization. In the present paper, we inspect a number of DTDs and XSDs harvested from the web and try to answer the following questions: (1) which of the extra features/expressiveness of XML Schema not allowed by DTDs are effectively used in practice; and, (2) how sophisticated are the structural properties (i.e. the nature of regular expressions) of the two formalisms. It turns out that at present real-world XSDs only sparingly use the new features introduced by XML Schema: on a structural level the vast majority of them can already be defined by DTDs. Further, we introduce a class of simple regular expressions and obtain that a surprisingly high fraction of the content models belong to this class. The latter result sheds light on the justification of simplifying assumptions that sometimes have to be made in XML research.
Early or delayed provision of an ankle-foot orthosis in patients with acute and subacute stroke: a randomized controlled trial

Objective: (1) To study the effects of providing ankle-foot orthoses in subjects with (sub)acute stroke; and (2) to study whether the point in time at which an ankle-foot orthosis is provided post-stroke (early or delayed) influences these effects. Design: Randomized controlled trial. Setting: Rehabilitation centre. Subjects: Unilateral hemiparetic stroke subjects with indication for use of an ankle-foot orthosis and maximal six weeks post-stroke. Interventions: Subjects were randomly assigned to: early provision (at inclusion; Week 1) or delayed provision (eight weeks later; Week 9). Outcome measures: 10-metre walk test, 6-minute walk test, Timed Up and Go Test, stairs test, Functional Ambulation Categories, Berg Balance Scale, Rivermead Mobility Index and Barthel Index; assessed in Weeks 1, 3, 9 and 11. Results: A total of 33 subjects were randomized (16 early, 17 delayed). Positive effects of ankle-foot orthoses were found two weeks after provision, both when provided early (significant effects on all outcomes) or delayed (Berg Balance Scale p = 0.011, Functional Ambulation Categories p = 0.008, 6-minute walk test p = 0.005, Timed Up and Go Test p = 0.028). Comparing effects after early and delayed provision showed that early provision resulted in increased levels of improvement on Berg Balance Scale (+5.1 points, p = 0.002), Barthel Index (+1.9 points, p = 0.002) and non-significant improvements on 10-metre walk test (+0.14 m/s, p = 0.093) and Timed Up and Go Test (–5.4 seconds, p = 0.087), compared with delayed provision. Conclusions: We found positive effects of providing ankle-foot orthoses in (sub)acute stroke subjects that had not used these orthoses before.
Development of a Panel of Genome-Wide Ancestry Informative Markers to Study Admixture Throughout the Americas

Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors. Complex historical factors have resulted in varying proportions of ancestral contributions between individuals within and among ethnic groups. We developed a panel of 446 ancestry informative markers (AIMs) optimized to estimate ancestral proportions in individuals and populations throughout Latin America. We used genome-wide data from 953 individuals from diverse African, European, and Native American populations to select AIMs optimized for each of the three main continental populations that form the basis of modern Latin American populations. We selected markers on the basis of locus-specific branch length to be informative, well distributed throughout the genome, capable of being genotyped on widely available commercial platforms, and applicable throughout the Americas by minimizing within-continent heterogeneity. We then validated the panel in samples from four admixed populations by comparing ancestry estimates based on the AIMs panel to estimates based on genome-wide association study (GWAS) data. The panel provided balanced discriminatory power among the three ancestral populations and accurate estimates of individual ancestry proportions (R2>0.9 for ancestral components with significant between-subject variance). Finally, we genotyped samples from 18 populations from Latin America using the AIMs panel and estimated variability in ancestry within and between these populations. This panel and its reference genotype information will be useful resources to explore population history of admixture in Latin America and to correct for the potential effects of population stratification in admixed samples in the region.
AnchorNet: A Weakly Supervised Network to Learn Geometry-Sensitive Features for Semantic Matching

Despite significant progress of deep learning in recent years, state-of-the-art semantic matching methods still rely on legacy features such as SIFT or HoG. We argue that the strong invariance properties that are key to the success of recent deep architectures on the classification task make them unfit for dense correspondence tasks, unless a large amount of supervision is used. In this work, we propose a deep network, termed AnchorNet, that produces image representations that are well-suited for semantic matching. It relies on a set of filters whose response is geometrically consistent across different object instances, even in the presence of strong intra-class, scale, or viewpoint variations. Trained only with weak image-level labels, the final representation successfully captures information about the object structure and improves results of state-of-the-art semantic matching methods such as the Deformable Spatial Pyramid or the Proposal Flow methods. We show positive results on the cross-instance matching task where different instances of the same object category are matched as well as on a new cross-category semantic matching task aligning pairs of instances each from a different object class.
Reciprocal Relations Between Harsh Discipline and Children's Externalizing Behavior in China: A 5-Year Longitudinal Study.

This research examined the overtime reciprocal relations between maternal and paternal harsh discipline and children's externalizing behavior. Seven hundred two father-mother dyads of children (6-9 years of age at baseline) completed measures of parental harsh discipline and children's externalizing behavior at five time points, 1 year apart. Autoregressive latent trajectory models revealed that maternal and paternal corporal punishment predicted subsequent children's externalizing behavior (parent-driven effects), whereas children's externalizing behavior predicted subsequent maternal and paternal psychological aggression (child-driven effects). The parent-driven effects became stronger, whereas the child-driven effects were equally strong across time. Furthermore, the parent-driven effects for corporal punishment were found for both boys and girls, whereas the child-driven effects for psychological aggression were found only for boys.
Ionotropic glutamate receptor antagonists modulate cue-induced reinstatement of ethanol-seeking behavior.

BACKGROUND Glutamatergic neurotransmission has been implicated in drug-environment conditioning, but little is known about the role of glutamate in alcohol seeking maintained by alcohol-associated cues. Therefore, we examined the effects of ionotropic glutamate receptor antagonists on cue-induced ethanol-seeking behavior in the extinction/reinstatement model. METHODS Rats were trained to orally self-administer ethanol (10% w/v) and a nonrewarding (80 microM) quinine solution on randomly alternating days. Ethanol and quinine availability were signaled by olfactory discriminative stimuli (S+/S-). In addition, ethanol delivery was accompanied by a light stimulus (CS+) and quinine delivery by an auditory stimulus (CS-). Thereafter, rats were subjected to extinction training during which responding had no programmed consequences. Reinstatement of responding was tested under three conditions: in the presence of the S-/CS-, S+/CS+, and S+/CS+ together with a small (0.2 ml) response-contingent oral ethanol dose at the beginning of the reinstatement session (S+/CS+/priming). We examined the effects of the noncompetitive NMDA receptor antagonist MK-801 (0, 0.05, 0.15 mg/kg intraperitoneally), the competitive NMDA antagonist CGP39551 (0, 5, 10 mg/kg intraperitoneally), the NMDA/glycine receptor antagonist L-701,324 (0, 2, 4 mg/kg intraperitoneally), the AMPA/kainate receptor antagonist CNQX (0, 0.5, 1.5 mg/kg intraperitoneally), and the opioid receptor antagonist naltrexone (0, 0.3, 1 mg/kg subcutaneously) on ethanol seeking under the S+/CS+/priming condition. RESULTS Presentation of the S+/CS+ stimulus condition reinstated extinguished responding, whereas presentation of the S-/CS- condition did not. Response-contingent ethanol priming enhanced reinstatement further. Under these reinstatement conditions, L-701,324, CNQX, and naltrexone inhibited ethanol-seeking behavior significantly. In contrast, MK-801 and CGP39551 failed to affect reinstated responding. CONCLUSIONS These results show that glutamate antagonism suppresses ethanol-seeking behavior induced by ethanol-paired stimuli. Furthermore, the data suggest that ionotropic glutamate receptors may have differential roles in mediation of this behavior.
Passive transfer of immunity into leprosy patients by transfusion of lymphocytes and by transfusion of Lawrence's transfer factor

About 1,200 million viable lymphocytes from normal but lepromin- and tuberculin-positive human beings were transfused in four patients of lepromatous and one of tuberculoid leprosy three times at monthly intervals. Three patients of lepromatous leprosy suffered from erythema modosum, whereas the other two developed severe reaction whenever put on the smallest dose of dapsone. In one patient of lepromatous leprosy, minimal improvement or none was observed, whereas in the remaining three cases of lepromatous and one of tuberculoid leprosy, clinical, bacteriological, as well as histological improvement occurred. Two of the five patients started to tolerate the dapsone during the period of study. The present study indicates that immunotherapy might have a definite role in the management of the disease especially in cases with erythema nodosum. Lawrence factor, prepared from leucocytes of normal donors, was transfused three times into four lepromatous leprosy patients who were intolerant to anti-leprosy drugs. The donors were healthy but were tuberculin and lepromin (Mitsuda) positive. The clinical, histological, bacteriological (morphological index), and immunological assessments of the patients were performed before and 5 months after starting the immunotherapy. In two patients conversion of Mitsuda reaction occurred, but there was no appreciable improvement in the clinical, histologic, and bacteriologic status of these patients.
A Data Mining Analysis of The Parkinson’s Disease

Clinical decision- making needs available information to be the guidance for physicians. Nowadays, data mining method is applied in medical research in order to analyze large volume of medical data. This study attempts to use data mining method to analyze the databank of Parkinson’s disease and explore whether the voice measurement variables can be the diagnostic tool for the Parkinson’s disease.
Acoustic Emission during Hydrogen Charging of a Pipeline Steel

Acoustic emission (AE) during hydrogen-induced cracking (HIC) of low-carbon pipeline steel immersed into H2S containing media was investigated aiming at discriminating between damage mechanisms and getting a better insight on the kinetics of damage. Two kinds of steel samples sensitive and resistant to hydrogen induced cracking were tested. Three different kinds of acoustic emission signals were discriminated by a cluster analysis involving either spectral shape recognition or parametric c-means classifier. It is demonstrated that AE is associated with three primary mechanisms involving hydrogen bubbles evolution, sulfide film formation and fracture due to HIC. Hence, AE is shown to be very efficient for quantitative description of hydrogen induced damage accumulation in steels.
Adding muscle where you need it: non‐uniform hypertrophy patterns in elite sprinters

Sprint runners achieve much higher gait velocities and accelerations than average humans, due in part to large forces generated by their lower limb muscles. Various factors have been explored in the past to understand sprint biomechanics, but the distribution of muscle volumes in the lower limb has not been investigated in elite sprinters. In this study, we used non‐Cartesian MRI to determine muscle sizes in vivo in a group of 15 NCAA Division I sprinters. Normalizing muscle sizes by body size, we compared sprinter muscles to non‐sprinter muscles, calculated Z‐scores to determine non‐uniformly large muscles in sprinters, assessed bilateral symmetry, and assessed gender differences in sprinters' muscles. While limb musculature per height‐mass was 22% greater in sprinters than in non‐sprinters, individual muscles were not all uniformly larger. Hip‐ and knee‐crossing muscles were significantly larger among sprinters (mean difference: 30%, range: 19–54%) but only one ankle‐crossing muscle was significantly larger (tibialis posterior, 28%). Population‐wide asymmetry was not significant in the sprint population but individual muscle asymmetries exceeded 15%. Gender differences in normalized muscle sizes were not significant. The results of this study suggest that non‐uniform hypertrophy patterns, particularly large hip and knee flexors and extensors, are advantageous for fast sprinting.
Profilin Is Essential for Tip Growth in the Moss Physcomitrella patens[W]

The actin cytoskeleton is critical for tip growth in plants. Profilin is the main monomer actin binding protein in plant cells. The moss Physcomitrella patens has three profilin genes, which are monophyletic, suggesting a single ancestor for plant profilins. Here, we used RNA interference (RNAi) to determine the loss-of-function phenotype of profilin. Reduction of profilin leads to a complete loss of tip growth and a partial inhibition of cell division, resulting in plants with small rounded cells and fewer cells. We silenced all profilins by targeting their 3′ untranslated region sequences, enabling complementation analyses by expression of profilin coding sequences. We show that any moss or a lily (Lilium longiflorum) profilin support tip growth. Profilin with a mutation in its actin binding site is unable to rescue profilin RNAi, while a mutation in the poly-l-proline binding site weakly rescues. We show that moss tip growing cells contain a prominent subapical cortical F-actin structure composed of parallel actin cables. Cells lacking profilin lose this structure; instead, their F-actin is disorganized and forms polarized cortical patches. Plants expressing the actin and poly-l-proline binding mutants exhibited similar F-actin disorganization. These results demonstrate that profilin and its binding to actin are essential for tip growth. Additionally, profilin is not needed for formation of F-actin, but profilin and its interactions with actin and poly-l-proline ligands are required to properly organize F-actin.
Reaction of antibiotic sulfadiazine with manganese dioxide in aqueous phase: Kinetics, pathways and toxicity assessment

ABSTRACT Sulfonamide antibiotics are often detected in terrestrial and aquatic environment, but little is known about abiotic degradation of these antibiotics. In the present study, the degradation of the sulfonamide antibiotic sulfadiazine by a synthesized δ-MnO2 was investigated. The initial reaction rate of sulfadiazine oxidized by manganese dioxide increased as the solution pH decreased by weakening electrostatic attraction between sulfadiazine and MnO2 and enhancing the reduction potential of MnO2. The presence of metal ions (Mn2+, Na+ and Ca2+), especially Mn2+, decreased the initial reaction rate by competitively adsorbing and reacting with MnO2. Two different products were identified during the reaction of sulfadiazine with MnO2 and the transformation of parent compound started with the formation of sulfadiazine radicals. Furthermore, toxicity assay results showed that the toxicity of products produced by bacteria decreased with elapse of reaction time. Results from the present study indicate that manganese dioxides in environmental matrix could be helpful in dissipation of sulfadiazine released into the environment.
Adult learning theories: Implications for learning and teaching in medical education: AMEE Guide No. 83

There are many theories that explain how adults learn and each has its own merits. This Guide explains and explores the more commonly used ones and how they can be used to enhance student and faculty learning. The Guide presents a model that combines many of the theories into a flow diagram which can be followed by anyone planning learning. The schema can be used at curriculum planning level, or at the level of individual learning. At each stage of the model, the Guide identifies the responsibilities of both learner and educator. The role of the institution is to ensure that the time and resources are available to allow effective learning to happen. The Guide is designed for those new to education, in the hope that it can unravel the difficulties in understanding and applying the common learning theories, whilst also creating opportunities for debate as to the best way they should be used.
JOINT EVALUATION OF NONLINEAR DISTORTION EFFECTS AND SIGNAL METRICS IN OFDM BASED TRANSMISSION SYSTEMS

In this contribution, we provide a theoretical characterisation of nonlinear distortion effects in orthogonal frequency division multiplex (OFDM) either in the downlink as well as in the uplink scenario. Previous papers presented on this topic considered OFDM signal as a Gaussian distributed mostly. It will be shown that the discussion must be strictly distinguished in case we observe the downlink or the uplink OFDM scenario. In the uplink scenario, where usually low number of subcarriers are employed for the transmission and Gaussianity does not hold, poorer performance results with than that of downlink scenario are achieved. This effect will be properly explained by theoretical framework and proved by the computer simulations. Moreover, the basic properties of commonly used signal metrics for the predictions of nonlinear distortion in OFDM are introduced.
High Level Synthesis of Recombinant Soluble Urokinase Receptor (CD87) by Ovarian Cancer Cells Reduces Intraperitoneal Tumor Growth and Spread in Nude Mice

Abstract Focussing of the serine protease urokinase (uPA) to the tumor cell surface via interaction with its receptor (uPAR) is an important step in tumor invasion and metastasis. The human ovarian cancer cell line OVMZ 6#8 was stably transfected with expression plasmids either encoding cellassociated uPAR (GPIuPAR) or a soluble form of uPAR (suPAR) lacking its glycan lipid anchor. In vitro, high level synthesis of functionally active recombinant suPAR inhibited cell proliferation and led to reduced cellassociated fibrin matrix degradation, whereas fibrinolytic activity was increased in OVMZ-6#8 cells overexpressing GPIuPAR. Both OVMZ-6#8-derived clones were inoculated into the peritoneum of nude mice and tested for tumor growth and spread. High level synthesis of recombinant suPAR (without altering the physiological expression levels of GPIuPAR and uPA in these cells) resulted in a significant reduction of tumor burden (up to 86%) in the xenogeneic mouse model. In contrast, overexpression of GPIuPAR in tumor cells did not affect tumor growth. Our results demonstrate that high levels of suPAR in the ovarian cancer cell vicinity can act as a potent scavenger for uPA, thereby significantly reducing tumor cell growth and cancer progression in vivo.