Miracle-dz/UniFAR-FTUs huggingface dataset:
Toward Improved Data on Student Mobility in Europe: Findings and Concepts of the Eurodata Study

This article on student mobility data in Europe has a double objective: First, it investigates which data on international mobility of students are being compiled and made available—and which are not—both at the international, the national, and the programme level. Second, it presents some of the student mobility data identified, and—based on an analysis of these data—it tries to depict a picture of the main trends in international student mobility into and out of 32 European countries. Next to analysing and presenting the availability and quality of data on international student mobility, the article also makes recommendations for the improvement of student mobility statistics both at the national and international levels.
Task type and task processing conditions as influences on foreign language performance

This paper examines the effects of planning and post-task activity on task-based performance. It is motivated by the need, given recent claims that task-based instruction has desirable pedagogic qualities, to investigate the effects of choosing different types of tasks, as well as different task implementation conditions, on the fluency, accuracy and complexity of the language which is produced when tasks are carried out. Three tasks are investigated: a personal task, a narrative task and a decision task. A 2-by-2 research design was used, with two planning conditions (10 minutes' planning time vs no planning time) and two post-task conditions (plus or minus knowledge of a post-task). Performance was assessed through the number of pauses (as a measure of fluency), the percentage of error-free clauses (to measure accuracy) and the level of subordination (as a measure of complexity). Confirming hypotheses and previous research, planning had clear effects on almost all measures. The hypothesis that foreknowledge of a post-task activity would selectively influence accuracy received only partial confirmation. Data from the present study was also related to results reported in an earlier study. This revealed that there is strong evidence of trade-off effects between the different dependent variables used, in that fluency, accuracy and complexity seem to enter into competition with one another, given the limited attentional capacities of second language users. Finally, there are indications that task characteristics interact with planning time and lead to selective improvements in particular areas. Tasks which contain clearer inherent structure, when planned, seem to favour accuracy, whereas tasks which require more on-line processing or which have complex outcomes, when planned, produce greater complexity.
Consensus transcriptome signature of perineural invasion in pancreatic carcinoma

Perineural invasion, the growth of tumor cells along nerves, is a key feature of pancreatic cancer. The cardinal symptom of pancreatic cancer, abdominal pain often radiating to the back, as well as the high frequency of local tumor recurrence following resection are both attributed to the unique ability of pancreatic tumor cells to invade the neuronal system. The molecular mechanisms underlying the neuroaffinity of pancreatic tumors are not completely understood. In this study, we developed a novel method to monitor ex vivo perineural invasion into surgically resected rat vagal nerves by different human pancreatic tumor cell lines. Genome-wide transcriptional analyses were employed to identify the consensus set of genes differentially regulated in all highly nerve-invasive (nerve invasion passage 3) versus less invasive (nerve invasion passage 0) pancreatic tumor cells. The critical involvement of kinesin family member 14 (KIF14) and Rho-GDP dissociation inhibitor β (ARHGDIβ) in perineural invasion was confirmed on RNA and protein levels in human pancreatic tumor specimens. We found significant up-regulation of KIF14 and ARHGDIβ mRNA levels in patients with pancreatic cancer, and both proteins were differentially expressed in tumor cells invading the perineural niche of pancreatic cancer patients as detected by immunohistochemistry. Moreover, functional knockdown of KIF14 and ARHGDIβ using small interfering RNA resulted in altered basal and/or perineural invasion of pancreatic tumor cells. Our work provides novel insights into the molecular determinants of perineural invasion in pancreatic cancer. The established nerve invasion model and the consensus signature of perineural invasion could be instrumental in the identification of novel therapeutic targets of pancreatic cancer as exemplified by KIF14 and ARHGDIβ. [Mol Cancer Ther 2009;8(6):1494–1504]
Sticky Masculinity

Despite the consolidation of “critical studies on men” or “masculinity studies” in recent years, critics have pointed to a kind of feminist theory deficit due to the relative lack of engagement with contemporary developments of feminist theory. By focusing on post-structuralist feminist and feminist phenomenological accounts of subjectivity, this article seeks to contribute to the emerging body of work that brings such theories into critical studies on men. I argue that making use of these perspectives is not only a matter of replacing dominant theories, but rather offers possibilities for creative rereading of earlier work on masculinity, which may not have been sufficiently appreciated from the viewpoint of dominant structural perspectives. My argument proceeds through a reading of John Stoltenberg as a post-structuralist feminist, and a reading of Victor Seidler as a feminist phenomenologist. I suggest that the study of masculinity can benefit from both traditions, and as an example I consider Jonathan Salisbury’s and David Jackson’s work on “boys’ work. ” Drawing in particular on Sara Ahmed’s innovative combination of post-structuralism and phenomenology, I suggest an understanding of masculinity as “sticky. ”
Indoor air pollution from solid biomass fuels combustion in rural agricultural area of Tibet, China.

UNLABELLED In this study, we are trying to investigate the indoor air pollution and to estimate the residents' pollution exposure reduction of energy altering in rural Tibet. Daily PM(2.5) monitoring was conducted in indoor microenvironments like kitchen, living-room, bedroom, and yard in rural Tibet from December 2006 to March 2007. For kitchen air pollution, impact of two fuel types, methane and solid biomass fuels (SBFs), were compared. Questionnaire survey on the domestic energy pattern and residents' daily activity pattern was performed in Zha-nang County. Daily average PM(2.5) concentrations in kitchen, living-room, bedroom, and yard were 134.91 microg/m(3) (mean, n = 45, 95%CI 84.02, 185.80), 103.61 microg/m(3) (mean, n = 21, 95%CI 85.77, 121.45), 76.13 microg/m(3) (mean, n = 18, 95%CI 57.22, 95.04), and 78.33 microg/m(3) (mean, n = 34, 95%CI 60.00, 96.65) respectively. Using SBFs in kitchen resulted in higher indoor pollution than using methane. PM(2.5) concentrations in kitchen with dung cake, fuel wood and methane use were 117.41 microg/m(3) (mean, n = 18, 95%CI 71.03, 163.79), 271.11 microg/m(3) (mean, n = 12, 95%CI 104.74, 437.48), and 46.96 microg/m(3) (mean, n = 15, 95%CI 28.10, 65.82) respectively. Family income has significant influence on cooking energy choice, while the lack of commercial energy supply affects the energy choice for heating more. The effects of two countermeasures to improve indoor air quality were estimated in this research. One is to replace SBFs by clean energy like methane, the other is to separate the cooking place from other rooms and by applying these countermeasures, residents' exposure to particulate matters would reduce by 25-50% (methane) or 20-30% (separation) compared to the present situation. PRACTICAL IMPLICATIONS Indoor air pollution caused by solid biomass fuels is one of the most important burdens of disease in the developing countries, which attracts the attention of environment and public health researchers, as well as policy makers. This paper gives a pilot research on the indoor air pollution and estimated the effects of some intervention policies in Tibet of China, where the living habits of the residents are quite different from other parts of the world. This work would be an important supply to the indoor air pollution studies, and would be helpful in policy making.
The generalized LASSO

In the last few years, the support vector machine (SVM) method has motivated new interest in kernel regression techniques. Although the SVM has been shown to exhibit excellent generalization properties in many experiments, it suffers from several drawbacks, both of a theoretical and a technical nature: the absence of probabilistic outputs, the restriction to Mercer kernels, and the steep growth of the number of support vectors with increasing size of the training set. In this paper, we present a different class of kernel regressors that effectively overcome the above problems. We call this approach generalized LASSO regression. It has a clear probabilistic interpretation, can handle learning sets that are corrupted by outliers, produces extremely sparse solutions, and is capable of dealing with large-scale problems. For regression functionals which can be modeled as iteratively reweighted least-squares (IRLS) problems, we present a highly efficient algorithm with guaranteed global convergence. This defies a unique framework for sparse regression models in the very rich class of IRLS models, including various types of robust regression models and logistic regression. Performance studies for many standard benchmark datasets effectively demonstrate the advantages of this model over related approaches.
Drug Use by Small Town Mexican American Youth: A Pilot Study

While the quality of drug use data for youth of Spanish origin is improving, there is still inadequate information about Mexican American youth in rural areas of the Southwest. A pilot study is presented in which the youth of a small town in the Southwest were surveyed regarding their drug and alcohol use. Mexican American and Anglo youth within that sample are compared on drug use variables and differences by gender are examined. Further comparisons are made with a national sample and a group of urban barrio youth. The literature is reviewed for studies on drug use among youth of the various Spanish-origin groups, and small town and rural drug use.
Experiencing vaginismus–sufferers beliefs about causes and effects

Abstract The present study examined the experience of vaginismus in 89 sufferers and ex-sufferers using quantitative and qualitative methodologies. The results provide insights into the effects of vaginismus on the sufferers' self perception and on their relationships with important others. It is suggested that vaginismus should not be regarded as a psychosexual problem but as a psychosocial experience in which defences have been created to protect the self, and that the vaginal spasm is only one of the many effects of this defence.
Occurrence of Choline and Glycine Betaine Uptake and Metabolism in the Family Rhizobiaceae and Their Roles in Osmoprotection

ABSTRACT The role of glycine betaine and choline in osmoprotection of various Rhizobium, Sinorhizobium,Mesorhizobium, Agrobacterium, andBradyrhizobium reference strains which display a large variation in salt tolerance was investigated. When externally provided, both compounds enhanced the growth of Rhizobium tropici,Sinorhizobium meliloti, Sinorhizobium fredii,Rhizobium galegae, Agrobacterium tumefaciens,Mesorhizobium loti, and Mesorhizobium huakuii, demonstrating their utilization as osmoprotectants. However, both compounds were inefficient for the most salt-sensitive strains, such asRhizobium leguminosarum (all biovars), Agrobacterium rhizogenes, Rhizobium etli, and Bradyrhizobium japonicum. Except for B. japonicum, all strains exhibit transport activity for glycine betaine and choline. When the medium osmolarity was raised, choline uptake activity was inhibited, whereas glycine betaine uptake was either increased in R. leguminosarum and S. meliloti or, more surprisingly, reduced in R. tropici, S. fredii, and M. loti. The transport of glycine betaine was increased by growing the cells in the presence of the substrate. With the exception ofB. japonicum, all strains were able to use glycine betaine and choline as sole carbon and nitrogen sources. This catabolic function, reported for only a few soil bacteria, could increase competitiveness of rhizobial species in the rhizosphere. Choline dehydrogenase and betaine-aldehyde dehydrogenase activities were present in the cells of all strains with the exception of M. huakuii and B. japonicum. The main physiological role of glycine betaine in the family Rhizobiaceae seems to be as an energy source, while its contribution to osmoprotection is restricted to certain strains.
Retinal pigment epithelial phenotype induced in human adipose tissue-derived mesenchymal stromal cells.

BACKGROUND AIMS The non-exudative form of age-related macular degeneration (ARMD) is characterized by a progressive decay of retinal pigment epithelium cells at the posterior pole of the eye. As mesenchymal stromal cells (MSC) have been shown to differentiate into various cell types from the mesodermal and ectodermal lineages, we investigated whether we can induce a phenotype displaying retinal pigment epithelium (RPE) characteristics. METHODS The differentiation of human lipo-aspirate-derived MSC toward the RPE lineage was triggered by exposure to conditioned medium from either human or porcine RPE cells. In a second approach we tested whether adding vasoactive intestinal peptide (VIP) is capable of further modifying differentiation processes. Resulting cell populations were assessed for expression of RPE-specific markers by immunofluorescence, quantitative real time (RT)-polymerase chain reaction (PCR) and Western blotting. The potential for pigment synthesis was assessed by the response to melanocyte-stimulating hormone (MSH). RESULTS Following culture of undifferentiated MSC with RPE-conditioned medium and/or VIP, expression of typical RPE markers bestrophin, cytokeratins 8 and 18 and RPE 65 was induced. MSH induced the formation of pigmented granula in differentiated MSC. CONCLUSIONS MSC are shown to express RPE markers upon induction with either RPE-conditioned medium and/or VIP. The gain of basic functional features of RPE cells was indicated by melanin synthesis. This alludes to a differentiation potential of MSC into the neuroectodermal lineage, yielding cells with phenotypic characteristics of RPE cells.
GRAIL: a unique mediator of CD4 T‐lymphocyte unresponsiveness

GRAIL (gene related to anergy in lymphocytes, also known as RNF128), an ubiquitin–protein ligase (E3), utilizes a unique single transmembrane protein with a split‐function motif, and is an important gatekeeper of T‐cell unresponsiveness. Although it may play a role in other CD4 T‐cell functions including activation, survival and differentiation, GRAIL is most well characterized as a negative regulator of T‐cell receptor responsiveness and cytokine production. Here, we review the recent literature on this remarkable E3 in the regulation of human and mouse CD4 T‐cell unresponsiveness.
Visual features involving motion seen from airport control towers

Visual motion cues are used by tower controllers to support both visual and anticipated separation. Some of these cues are tabulated as part of the overall set of visual features used in towers to separate aircraft. An initial analyses of one motion cue, landing deceleration, is provided as a basis for evaluating how controllers detect and use it for spacing aircraft on or near the surface. Understanding cues like it will help determine if they can be safely used in a remote/virtual tower in which their presentation may be visually degraded.
Mobile Learning in a Large Blended Computer Science Classroom: System Function, Pedagogies, and Their Impact on Learning

The computer science classes in China's institutions of higher education often have large numbers of students. In addition, many institutions offer ldquoblendedrdquo classes that include both on-campus and online students. These large blended classrooms have long suffered from a lack of interactivity. Many online classes simply provide recorded instructor lectures to which distance students listen after downloading. This format only reinforces the negative effects of passive nonparticipatory learning. At a major university in Shanghai, researchers and developers actively seek technological interventions that can greatly increase interactivity in blended classes. They have developed a cutting-edge mobile learning system that can deliver live broadcasts of real-time classroom teaching to online students with mobile devices. Their system allows students to customize their means of content-reception, based on when and where the students are tuning into the broadcast. The system also supports short text-messaging and instant polls. Through these features, students can ask questions and make suggestions in real time, and the instructor can respond immediately. This paper describes this system in detail and also reports results from a formal implementation of the system with a blended classroom of 562 students (of whom 90% were online).
Self or group? Cultural effects of training on self-efficacy and performance.

The author gratefully acknowledges the comments and suggestions of Elaine Mosakowski and Anne Tsui on an earlier draft of this paper. Requests for reprints and other correspondence should be addressed to the author at the Graduate School of Management, University of California at Irvine, Irvine, CA 92717. The author would like to thank Bao Ji Ming, Luo Xing-jian, Zou Qiming, and Zhang Yong-lin for their assistance in collecting data in the People's Republic of China as well as Susan Peterson for her assistance in collecting the data in the United States. This paper examines the theoretical and empirical relationship of training and individualism-collectivism to self-efficacy (a person's estimate of his or her ability to perform a task) and performance in studies of managers from Hong Kong, the People's Republic of China, and the United States. A laboratory experiment and a six-month field experiment were used to test hypotheses predicting that for individualists, self-focused training would have a stronger impact on self-efficacy and performance than would group-focused training and, for collectivists, group-focused training would have a stronger impact on self-efficacy and performance than would individual-focused training. The results show consistent support for the hypotheses at both a cultural and an individual level of analysis. A general model of self-efficacy and culture in an organizational environment is discussed. '
Brain–behavior relationships in the experience and regulation of negative emotion in healthy children: Implications for risk for childhood depression

Abstract Structural and functional alterations in a variety of brain regions have been associated with depression and risk for depression across the life span. A majority of these regions are associated with emotion reactivity and/or regulation. However, it is generally unclear what mechanistic role these alterations play in the etiology of depression. A first step toward understanding this is to characterize the relationships between variation in brain structure/function and individual differences in depression severity and related processes, particularly emotion regulation. To this end, the current study examines how brain structure and function predict concurrent and longitudinal measures of depression symptomology and emotion regulation skills in psychiatrically healthy school-age children (N = 60). Specifically, we found that smaller hippocampus volumes and greater responses to sad faces in emotion reactivity regions predict increased depressive symptoms at the time of scan, whereas larger amygdala volumes, smaller insula volumes, and greater responses in emotion reactivity regions predict decreased emotion regulation skills. In addition, larger insula volumes predict improvements in emotion regulation skills even after accounting for emotion regulation at the time of scan. Understanding brain–behavior relationships in psychiatrically healthy samples, especially early in development, will help inform normative developmental trajectories and neural alterations in depression and other affective pathology.
Plasma sRAGE and N‐(carboxymethyl) lysine in patients with CHF and/or COPD

Knowledge of the role of the receptor for advanced glycation end products (RAGE), particularly its soluble form (sRAGE), and of its advanced glycation end product (AGE) ligand, N‐(carboxymethyl)lysine adducts (CML), is limited in chronic heart failure (CHF) and in chronic obstructive pulmonary disease (COPD). We evaluated whether the AGE/RAGE system is activated in stable CHF and COPD, and whether plasma sRAGE and CML levels are affected by clinical and functional parameters.
A Novel Pathway Analysis Approach Based on the Unexplained Disregulation of Genes

A crucial step in the understanding of any phenotype is the correct identification of the signaling pathways that are significantly impacted in that phenotype. However, most current pathway analysis methods produce both false positives as well as false negatives in certain circumstances. We hypothesized that such incorrect results are due to the fact that the existing methods fail to distinguish between the primary dis-regulation of a given gene itself and the effects of signaling coming from upstream. Furthermore, a modern whole-genome experiment performed with a next-generation technology spends a great deal of effort to measure the entire set of 30000–100000 transcripts in the genome. This is followed by the selection of a few hundreds differentially expressed genes, step that literally discards more than 99% of the collected data. We also hypothesized that such a drastic filtering could discard many genes that play crucial roles in the phenotype. We propose a novel topology-based pathway analysis method that identifies significantly impacted pathways using the entire set of measurements, thus allowing the full use of the data provided by NGS techniques. The results obtained on 24 real data sets involving 12 different human diseases, as well as on 8 yeast knock-out data sets show that the proposed method yields significant improvements with respect to the state-of-the-art methods: SPIA, GSEA, and GSA. Availability: Primary dis-regulation analysis is implemented in R and included in ROntoTools Bioconductor package (versions $\geq$2.0.0). https://www.bioconductor. org/packages/release/bioc/html/ROntoTools.html.
Terrorist Threats and Police Performance: A Study of Israeli Communities

In recent years, scholars and police practitioners have become increasingly concerned with the possible impacts of terrorism on police performance. Some scholars have argued that increased terrorist threats will reduce resources that are devoted to ordinary policing functions such as solving crimes, and that anti-terrorism functions may overshadow traditional police activities. Others have suggested that heightened surveillance due to terrorist threats could have unintended crime prevention benefits. In this study, we examine the impacts of terrorist threats on one aspect of police performance-the clearance of police files. Using Israel during the Second Intifada (2000-04) as a case study, we analyse the impact of level of terrorist threat, while controlling for other possible confounding factors, separating out communities that are primarily Jewish or Arab. Our analyses suggest that terrorist threats have a significant impact upon police performance, though that impact varies strongly by type of community. Higher levels of threat are associated with lower proportions of cleared cases in the majority Jewish communities, and higher proportions in the majority Arab communities.