Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk of deep vein thrombosis and pulmonary embolism in asthma

Increasing evidence suggests that patients with asthma have activated coagulation within the airways. Whether this leads to an increase in venous thromboembolic events is unknown. We therefore assessed the incidence of venous thromboembolic events in patients with mild-to-moderate and severe asthma as compared with an age- and sex-matched reference population. 648 patients with asthma (283 with severe and 365 patients with mild-to-moderate asthma) visiting three Dutch outpatient asthma clinics were studied. All patients completed a questionnaire about a diagnosis of deep vein thrombosis and pulmonary embolism in the past, their risk factors, history of asthma and medication use. All venous thromboembolic events were objectively verified. In total, 35 venous thromboembolic events (16 deep vein thrombosis and 19 pulmonary embolism) occurred at a median age of 39 (range 20–63) years. The incidence of pulmonary embolism in patients with severe asthma was 0.93 (95% CI 0.42–1.44) per 1000 person-years, 0.33 (95% CI 0.07–0.60) in mild-to-moderate asthma and 0.18 (95% CI 0.03–0.33) in the general population, respectively. Severe asthma and oral corticosteroid use were independent risk factors of pulmonary embolism (hazard ratios 3.33 (1.16–9.93) and 2.82 (1.09–7.30), respectively). Asthma was not associated with deep vein thrombosis. Severe asthma greatly enhances the risk of pulmonary embolism, particularly if chronic corticosteroids are used. Severe asthma greatly enhances the risk of pulmonary embolism, particularly if chronic corticosteroids are used http://ow.ly/moNaO
A Measurement Study of Data-Intensive Network Traffic Patterns in a Private Cloud

In this work we investigate the impact of virtualization on the raw network performance attainable by "data-intensive" applications deployed in a private cloud. To this end we developed a new software tool, called OSMeF, to take repeatable measurements on our Open Stack-based platform. We also discuss the implications of our measurement results toward informed deployments of distributed applications such as Hadoop.
Optogenetic Activation of Cajal-Retzius Cells Reveals Their Glutamatergic Output and a Novel Feedforward Circuit in the Developing Mouse Hippocampus

Cajal-Retzius cells orchestrate the development of cortical circuits by secreting the glycoprotein reelin. However, their computational functions are still unknown. In fact, the nature of their postsynaptic targets, major neurotransmitter released, as well as the class of postsynaptic receptors activated by their firing remain unclear. Here, we have addressed these questions by activating Cajal-Retzius cells optogenetically in mouse hippocampal slices. Light delivered to stratum lacunosum-moleculare triggered EPSCs both on local interneurons and on pyramidal cells. Responses recorded under voltage-clamp conditions had identical short latencies and similar amplitudes, but were kinetically different (i.e., faster in interneurons vs pyramidal cells). In both cases, responses were blocked by TTX, indicating that they were generated by action potential-dependent release. Responses in interneurons were rescued by the addition of 4-AP to TTX, and decreased when presynaptic firing in Cajal-Retzius cells was reduced by the chemokine CXCL12, indicating the existence of a direct Cajal-Retzius cell-interneuron monosynaptic connection. Although the combined application of 4-AP and TTX did not rescue responses in pyramidal cells, neither were they affected by the GABAA receptor blocker gabazine, which would be expected if they were polysynaptic. Both connections showed physiological and pharmacological properties indicating the involvement of AMPA- and NMDA-type glutamate receptors. The connectivity from presynaptic Cajal-Retzius cells to interneurons was strong enough to generate long-latency feedforward GABAergic input onto pyramidal cells. We propose that this newly defined Cajal-Retzius cell-dependent microcircuit may regulate synaptic plasticity and dendritic development in stratum lacunosum-moleculare, thus impacting the integrative properties of the developing hippocampus.
Political Competition, Tax Salience and Accountability: Theory and Some Evidence from Italy

This paper argues that high political competition does not necessarily induce policy makers to perform better as previous research has shown. We develop a political economy model and we show that when political competition is tight, and elected politicians can rely on more tax instruments, they will substitute salient taxes with less salient ones, which are not necessarily preferable. These predictions are largely confirmed using a dataset on Italian municipal elections and taxes.
Detection and apparent survival of PIT‐tagged stream fish in winter

Abstract Environmental fluctuations exert strong control on behavior, survival, and fitness of stream biota. Technical improvements increasingly allow for tracking the response of large numbers of individuals to environmental fluctuations, for instance, by remote detection of animals equipped with PIT (passive integrated transponder) tags. PIT tags were implanted into 393 juvenile and adult brown trout Salmo trutta L. and European sculpin Cottus gobio L. in a boreal stream subjected to considerable ice formation. With weekly trackings over 6 months, we quantified apparent survival and detection probability in relation to biological, environmental, and methodological factors. Individuals with a higher physical condition in autumn showed a higher apparent survival; this pattern was consistent across all species and age classes. Detection probability decreased with increasing thickness of the surface ice layer; this effect was most pronounced for juvenile trout and benthic‐living sculpin, both tagged with smaller‐sized tags. Detection probability was reduced in structurally complex habitats. Our study demonstrates that apparent survival and particularly detection probability may show pronounced spatiotemporal variation. In order to compare results from different sampling occasions and sites, a good knowledge of the study site and of the regulating factors is crucial.
Conserved Regulators of Mating Are Essential for Aspergillus fumigatus Cleistothecium Formation

ABSTRACT Sexual reproduction of the human pathogen Aspergillus fumigatus (teleomorph: Neosartorya fumigata) was assumed to be absent or cryptic until recently, when fertile crosses among geographically restricted environmental isolates were described. Here, we provide evidence for mating, fruiting body development, and ascosporogenesis accompanied by genetic recombination between unrelated, clinical isolates of A. fumigatus, and this evidence demonstrates the generality and reproducibility of this long-time-undisclosed phase in the life cycle of this heterothallic fungus. Successful mating requires the presence of both mating-type idiomorphs MAT1-1 and MAT1-2, as does expression of genes encoding factors presumably involved in this process. Moreover, analysis of an A. fumigatus mutant deleted for the nsdD gene suggests a role of this conserved regulator of cleistothecium development in hyphal fusion and hence heterokaryon formation.
Bio‐inspired Design of Submerged Hydrogel‐Actuated Polymer Microstructures Operating in Response to pH

IO N Responsive and reversibly actuating surfaces have attracted signifi cant attention recently due to their promising applications as dynamic materials [ 1 ] that may enable microfl uidic mixing, [ 2 ] particle propulsion and fl uid transport, [ 3 ] capture and release systems, [ 4 ] and antifouling. [ 5 ] Analogs in nature serve as inspiration for the design of such advanced adaptive materials systems—microorganisms use fl agella for propulsion, [ 6 ] cilia line the human respiratory tract to sweep mucus from the lungs and prevent bacterial accumulation, [ 7 ] and echinoderms use pedicellariae for body cleaning and food capture. [ 8 ] Signifi cant characteristics of these biological systems include functionality in a fl uidic environment, controllable actuation direction or pattern, and the ability to translate chemical signals or stimulus into mechanical motion. Researchers have taken various approaches to fabricating biomimetic actuators, among which are biomorph actuators made using microelectromechanical systems (MEMS) technology, [ 9 ] magnetically actuated polydimethylsiloxane (PDMS) structures, [ 10 ] and artifi cial cilia or actuators made from responsive gel. [ 11 , 12 ] However, most fabricated actuators, such as MEMS or magnetically actuated PDMS posts, must be driven by an external force or fi eld and are not responsive to chemical stimuli. Actuating structures that have been made from responsive hydrogel are either low aspect ratio and their motion is not patternable, [ 11 ] or the movement is irreversible. [ 12 ] Microscale actuation systems which exhibit reversible chemo-mechanical response and control of actuation direction or pattern have proven diffi cult to achieve. Inspired by biological actuators, which can be broadly interpreted as composites consisting of an active “muscle” component coupled with a passive “bone” structure, we recently developed a hybrid actuation system in which a crosslinked polyacrylamide-based hydrogel, acting as an analog to muscle, drives the movement of embedded silicon [ 13 , 14 ] or polymer [ 15 ]
Risk Estimation Based on Chromosomal Aberrations Induced by Radiation

Abstract Durante, M. , Bonassi, S. , George, K. and Cucinotta, F. A. Risk Estimation based on Chromosomal Aberrations Induced by Radiation. Radiat. Res. 156, 662–667 (2001). The presence of a causal association between the frequency of chromosomal aberrations in peripheral blood lymphocytes and the risk of cancer has been substantiated recently by epidemiological studies. Cytogenetic analyses of crew members of the Mir Space Station have shown that a significant increase in the frequency of chromosomal aberrations can be detected after flight, and that such an increase is likely to be attributed to the radiation exposure. The risk of cancer can be estimated directly from the yields of chromosomal aberrations, taking into account some aspects of individual susceptibility and other factors unrelated to radiation. However, the use of an appropriate technique for the collection and analysis of chromosomes and the choice of the structural aberrations to be measured are crucial in providing sound results. Based on the fraction of aberrant lymphocytes detected before and after flight, the relative risk after a long-term Mir mission is estimated to be about 1.2–1.3. The new technique of mFISH can provide useful insights into the quantification of risk on an individual basis.
Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum

The bifunctional proline catabolic flavoenzyme, proline utilization A (PutA), catalyzes the oxidation of proline to glutamate via the sequential activities of FAD-dependent proline dehydrogenase (PRODH) and NAD+-dependent Δ1-pyrroline-5-carboxylate dehydrogenase (P5CDH) domains. Although structures for some of the domains of PutA are known, a structure for the full-length protein has not previously been solved. Here we report the 2.1 Å resolution crystal structure of PutA from Bradyrhizobium japonicum, along with data from small-angle x-ray scattering, analytical ultracentrifugation, and steady-state and rapid-reaction kinetics. PutA forms a ring-shaped tetramer in solution having a diameter of 150 Å. Within each protomer, the PRODH and P5CDH active sites face each other at a distance of 41 Å and are connected by a large, irregularly shaped cavity. Kinetics measurements show that glutamate production occurs without a lag phase, suggesting that the intermediate, Δ1-pyrroline-5-carboxylate, is preferably transferred to the P5CDH domain rather than released into the bulk medium. The structural and kinetic data imply that the cavity serves both as a microscopic vessel for the hydrolysis of Δ1-pyrroline-5-carboxylate to glutamate semialdehyde and a protected conduit for the transport of glutamate semialdehyde to the P5CDH active site.
Fedosov quantization in algebraic context

We consider the problem of quantization of smooth symplectic varieties in the algebro-geometric setting. We show that, under appropriate cohomological assumptions, the Fedosov quantization procedure goes through with minimal changes. The assumptions are satisfied, for example, for affine and for projective varieties. We also give a classification of all possible quantizations.
Providing High and Controllable Performance in Multicore Systems Through Shared Resource Management

Multiple applications executing concurrently on a multicore system interfere with each other at different shared resources such as main memory and shared caches. Such inter-application interference, if uncontrolled, results in high system performance degradation and unpredictable application slowdowns. While previous work has proposed application-aware memory scheduling as a solution to mitigate inter-application interference and improve system performance, previously proposed memory scheduling techniques incur high hardware complexity and unfairly slowdown some applications. Furthermore, previously proposed memory-interference mitigation techniques are not designed to precisely control application performance. This dissertation seeks to achieve high and controllable performance in multicore systems by mitigating and quantifying the impact of shared resource interference. First, towards mitigating memory interference and achieving high performance, we propose the Blacklisting memory scheduler that achieves high performance and fairness at low complexity. Next, towards quantifying the impact of memory interference and achieving controllable performance in the presence of memory bandwidth interference, we propose the Memory Interference induced Slowdown Estimation (MISE) model. We propose and demonstrate two use cases that can leverage MISE to provide soft performance guarantees and high overall performance/fairness. Finally, we seek to quantify the impact of shared cache interference on application slowdowns, in addition to memory bandwidth interference. Towards this end, we propose the Application Slowdown Model (ASM). We propose and demonstrate several use cases of ASM that leverage it to provide soft performance guarantees and improve performance and fairness.
Sympathy for the sensor network debugger

Being embedded in the physical world, sensor networks present a wide range of bugs and misbehavior qualitatively different from those in most distributed systems. Unfortunately, due to resource constraints, programmers must investigate these bugs with only limited visibility into the application. This paper presents the design and evaluation of Sympathy, a tool for detecting and debugging failures in sensor networks. Sympathy has selected metrics that enable efficient failure detection, and includes an algorithm that root-causes failures and localizes their sources in order to reduce overall failure notifications and point the user to a small number of probable causes. We describe Sympathy and evaluate its performance through fault injection and by debugging an active application, ESS, in simulation and deployment. We show that for a broad class of data gathering applications, it is possible to detect and diagnose failures by collecting and analyzing a minimal set of metrics at a centralized sink. We have found that there is a tradeoff between notification latency and detection accuracy; that additional metrics traffic does not always improve notification latency; and that Sympathy's process of failure localization reduces.
Uptake and distribution of carotenoids, retinol, and tocopherols in human colonic epithelial cells in vivo.

Studies suggest that micronutrients such as the tocopherols, retinol, and the carotenoids have a chemopreventive action against colonic carcinogenesis and that they may be essential for the functioning and structural integrity of the gastrointestinal epithelium. In this study, we have determined the concentrations of tocopherols, retinol, and the carotenoids in human colonic epithelial cells using a noninvasive procedure developed in this laboratory (G.P. Albaugh et al., Int. J. Cancer, 52: 347-350, 1992). In subjects on a normal diet, almost all of these micronutrients were restricted to cells in the density range of rho 1.065-1.090 and rho 1.090-1.110. The lighter fraction (rho 1.033-1.064), representing the most senescent subpopulation, retained these micronutrients only when the subjects were on diets rich in vegetables. Cells isolated from subjects on their usual diets gave the following values expressed as ng/10(7) cells: alpha-tocopherol, 93-151; gamma-tocopherol, 152-280; retinol, 12-20; lutein, 4-18; cryptoxanthin, not detected; lycopene, 0-17; alpha-carotene, 3-7; and beta-carotene, 6-9. Peak responses in specific micronutrients following 5 days on a high carotenoid diet showed a lag period of at least 5 days, corresponding to the turnover rates of the epithelium itself. The evidence suggests that uptake of these micronutrients by the colonic mucosa occurs in the deep cryptal zone where the actively proliferating cells extract the nutrients from the systemic circulation.
Hypofractionated Irradiation Has Immune Stimulatory Potential and Induces a Timely Restricted Infiltration of Immune Cells in Colon Cancer Tumors

In addition to locally controlling the tumor, hypofractionated radiotherapy (RT) particularly aims to activate immune cells in the RT-modified microenvironment. Therefore, we examined whether hypofractionated RT can activate dendritic cells (DCs), induce immune cell infiltration in tumors, and how the chronology of immune cell migration into tumors occurs to gain knowledge for future definition of radiation breaks and inclusion of immunotherapy. Colorectal cancer treatments offer only limited survival benefit, and immunobiological principles for additional therapies need to be explored with preclinical models. The impact of hypofractionated RT on CT26 colon cancer tumor cell death, migration of DCs toward supernatants (SN) of tumor cells, and activation of DCs by SN were analyzed. The subcutaneous tumor of a BALB/c-CT26 mouse model was locally irradiated with 2 × 5 Gy, the tumor volume was monitored, and the infiltration of immune cells in the tumor was determined by flow cytometry daily. Hypofractionated RT induced a mixture of apoptotic and necrotic CT26 cells, which is known to be in particular immunogenic. DCs that migrated toward SN of CT26 cells particularly upregulated the activation markers CD80 and CD86 when in contact with SN of irradiated tumor cells. After hypofractionated RT, the tumor outgrowth was significantly retarded and in the irradiated tumors an increased infiltration of macrophages (CD11bhigh/F4-80+) and DCs (MHC-II+), but only between day 5 and 10 after the first irradiation, takes place. While CD4+ T cells migrated into non-irradiated and irradiated tumors, CD8+ T cells were only found in tumors that had been irradiated and they were highly increased at day 8 after the first irradiation. Myeloid-derived suppressor cells and regulatory T cells show regular turnover in irradiated and non-irradiated tumors. Tumor cell-specific anti-IgM antibodies were enhanced in the serum of animals with irradiated tumors. We conclude that hypofractionated RT suffices to activate DCs and to induce infiltration of innate and adaptive immune cells into solid colorectal tumors. However, the presence of immune cells in the tumor which are beneficial for antitumor immune responses is timely restricted. These findings should be considered when innovative multimodal tumor treatment protocols of distinct RT with immune therapies are designed and clinically implemented.
Self-reported measures of mindfulness in meditators and non-meditators: A cross-sectional study

Context: Mindfulness forms an important component of meditation practice and has been increasingly popular around the world. There has been growing interest in studying the mindful component of various meditation techniques. One of the various forms of mindfulness is the practice of a unique technique called cyclic mediation (CM). We aimed at ascertaining the level of mindfulness in experienced practitioners of CM using a Mindfulness Attention Awareness Scale (MAAS). Materials and Methods: MAAS was administered anonymously in a classroom setup and two of the project coordinators were present to supervise the administration and to assist the participants where necessary. We executed a cross sectional design. One hundred and thirty-three (n = 133) healthy male volunteers (66 meditators and 67 non-meditators) with ages ranging from 25 to 35 years participated in the study. Meditators had a minimum 3 years experience of meditation. Results: Data were analyzed using IBM SPSS 20. The data were checked for normality and an independent samples t-test was employed to compare the means of both the groups. MAAS scores were significantly higher in meditators as compared with the non-meditators (P < 0.001). We found a positive correlation (r = 0.620) between the years of meditation practice and the levels of trait mindfulness. Conclusions: CM can lead to development of higher levels of mindfulness and may have the ability to positively impact mental states and attention, thereby offering the potential for prevention of clinical levels of psychopathology and improving overall psychological well-being in healthy individuals.
Using WhatsApp and Facebook Online Social Groups for Smoking Relapse Prevention for Recent Quitters: A Pilot Pragmatic Cluster Randomized Controlled Trial

Background Quit attempters often have episodes of smoking relapse before they eventually quit. Interactive text messaging through mobile phones has been shown to increase abstinence. This service can be potentially applied on the platform of a social networking service to help quitters maintain abstinence. Objective Our aim was to determine if the group discussion and reminders via the WhatsApp or Facebook social group were effective to prevent smoking relapse in quitters who had stopped smoking recently. Methods This was a single-blinded, parallel, 3-arm pilot cluster randomized controlled trial allocating recent quitters, who had completed an 8-week treatment and reported abstinence for at least 7 days, to WhatsApp (n=42), Facebook (n=40), and a control group (n=54). The 2 intervention groups participated in a 2-month online group discussion with either WhatsApp or Facebook moderated by a trained smoking cessation counselor and received a self-help booklet on smoking cessation. The control group only received the booklet. The primary outcome was the 2- and 6-month relapse rates, defined as the proportion of participants who smoked at least 5 cigarettes in 3 consecutive days. Results Fewer participants in the WhatsApp group (17%, 7/42) reported relapse than the control group (42.6%, 23/54) at 2-month (OR 0.27, 95% CI 0.10-0.71) and 6-month (40.5%, 17/42 vs 61.1%, 33/54; OR 0.43, 95% CI 0.19-0.99) follow-ups. The Facebook group (30.0%, 12/40) had an insignificantly lower relapse rate than the control group (42.6%, 23/54) at 2-month (OR 0.58, 95% CI 0.24-1.37) and 6-month (52.5%, 13/40 vs 61.1%, 33/54; OR 0.70, 95% CI 0.31-1.61) follow-ups. The WhatsApp social groups had more moderators’ posts (median 60, IQR 25 vs median 32, IQR 7; P=.05) and participants’ posts (median 35, IQR 50 vs median 6, IQR 9; P=.07) than their Facebook counterparts, but the difference was insignificant. Conclusions The intervention via the WhatsApp social group was effective in reducing relapse probably because of enhanced discussion and social support. Inactive discussion in the Facebook social group might have attributed to the lower effectiveness. ClinicalTrial Clinicaltrials.gov NCT02007369; https://clinicaltrials.gov/show/NCT02007369 (Archived by WebCite® at http://www.webcitation.org/6c3RbltQG)