Miracle-dz/UniFAR-FTUs huggingface dataset:
Fabry Disease in a Renal Allograft

Incidental findings of rare diseases in organ donors can be seen in allograft biopsies that may have profound implications for the recipient and for the donor and their family. Fabry disease is an X‐linked recessive lipid storage disease with cardiovascular, renal and lenticular abnormalities. Phenotypic expression in female heterozygote carriers depends on lyonization. Minimal data exists on outcomes of transplanted kidneys from carriers of Fabry disease.
Ethics Training, Ethical Context, and Sales and Marketing Professionals’ Satisfaction with Supervisors and Coworkers

Because organizational support for ethical conduct is valued highly in personal selling and sales management, ethics training, functioning through a company’s ethical values and culture, should prompt greater satisfaction with supervisors and coworkers because these individuals play a part in the ethical practices that impact job satisfaction in others. Using a national sample of 324 sales and marketing professionals representing a variety of organizations, this study examined the mediating role of perceived ethical context in the proposed relationships between hours of ethics training and satisfaction with supervisors and coworkers. The results indicated that the focal variables were indeed related, with either full or partial mediation identified, using two separate measures of perceived ethical context. Organizational leaders in the sales and marketing professions should consider using ethics training to institutionalize an ethical environment in sales organizations, as well as involving sales managers and other professionals in this institutionalization process. Such efforts could yield greater employee satisfaction for supervisors and coworkers.
Customer Deviance in Resort Hotels: The Case of Turkey

This study aims to investigate customer deviance directed against employees working in the hotel industry. First, the literature about the dark side of customers is reviewed. Second, the source of deviant behavior is discussed. Third, the methodology is explained. Finally, the research findings are presented. The assessment of findings is based on 21 semistructured interviews. Although there are some serious deviant behaviors such as stabbing and physical sexual harassment, the deviant behaviors are generally seen as yelling at employees and behaving impolitely, which made employees questioning their status of work and dispirited. The study findings also suggest that the customers from different countries have different deviant behaviors.
When Personal and Professional Values Conflict: Trainee Perspectives on Tensions Between Religious Beliefs and Affirming Treatment of LGBT Clients

At times the personal beliefs or values of graduate students in training programs for professional psychology can create complications in their providing therapy for certain patient populations. This issue has been brought to national attention recently through several prominent legal cases in which students have contested their expulsion from graduate programs due to their assertions that they were unable to treat clients in same-sex relationships because of their own religious beliefs. The goals of the current article are to (a) review the literature on values conflicts, (b) provide an analysis of how portions of our professional Ethics Code directly relate to this issue, (c) describe a developmentally sensitive theoretical framework that is designed to foster the growth of ethical reasoning over time, and (d) provide a forum for trainee perspectives on this issue based on trainees’ responses to an ethical vignette describing an intern struggling with a values conflict. The trainee quotations are used to structure a discussion of practical recommendations for how to handle values conflicts within the context of training and clinical supervision in professional psychology.
Hispanic American Students' Cultural Orientation: Does Geographic Location, Institutional Type, or Level of Stress have an Effect?

This article looks at 370 Hispanic college students from institutional locations where Hispanics are significantly present in the population and from areas were Hispanics are not a critical mass. The Bicultural Orientation Model was used as a framework to determine whether geographic location influenced the students’ level of acculturation and/or level of ethnic identification. The findings indicate that students in areas where Hispanic Americans do not have a critical mass adjusting to the majority culture at a higher level than students in critical mass locales. No difference was found in their level of ethnic identity. Cultural orientation was not found to be associated with institutional type or scores on the College Stress Inventory.
Nitrogen partitioning, energy use efficiency and isotopic fractionation measurements from cows differing in genetic merit fed low-quality pasture in late lactation

The study was carried out to evaluate energy and nitrogen (N) use efficiencies of high and low breeding worth (BW) cow groups relative to N isotopic fractionation (Δ15N). Eight high- and eight low-BW cows (mean BW index = 198 and 57, respectively) in late lactation were used to conduct an N balance study with all cows fed autumn pasture. Individual cow pasture DM intake, N intake and N outputs of milk, urine and faeces were quantified. Plasma sample from each cow was harvested. Feed, plasma, faeces, urine and milk samples were measured for δ15N and calculated for Δ15N. Urea N in milk and plasma, and urinary excretion of purine derivatives were also measured. The metabolisable energy (ME) intake, milk energy output, and energy and N use efficiencies of high-BW cows were greater on average than low-BW cows. Conversely, the ratios of urinary N excretion to faecal N excretion and urinary N excretion to N intake were greater for low-BW cows than high-BW cows. There was no effect of BW groups on manure N output, apparent N digestibility, retained N, purine derivatives excretion or ratio of purine derivatives excretion to ME intake. No relationships were found between N and energy efficiencies and δ15N measurements. Regression analysis with individual cow measurement showed plasma δ15N – feed δ15N was negatively correlated with DM intake. N use efficiency was positively correlated with BW. High genetic merit cows are more efficient in N and energy use than lower genetic merit cows when fed low quality pasture in late lactation. Plasma δ15N – feed δ15N was proved to be a potential indicator of DM intake for individual cows when identical feed was offered. BW may be used to predict N use efficiency for individual cows.
The roles of monkey M1 neuron classes in movement preparation and execution

The motor cortices exhibit substantial activity while preparing movements, yet the arm remains still during preparation. We investigated whether a subpopulation of presumed inhibitory neurons in primary motor cortex (M1) might be involved in “gating” motor output during preparation, while permitting output during movement. This hypothesis predicts a release of inhibition just before movement onset. In data from M1 of two monkeys, we did not find evidence for this hypothesis: few neurons exhibited a clear pause during movement, and these were at the tail end of a broad distribution. We then identified a subpopulation likely to be enriched for inhibitory interneurons, using their waveform shapes. We found that the firing rates of this subpopulation tended to increase during movement instead of decreasing as predicted by the M1 gating model. No clear subset that might implement an inhibitory gate was observed. Together with previous evidence against upstream inhibitory mechanisms in premotor cortex, this provides evidence against an inhibitory “gate” for motor output in cortex. Instead, it appears that some other mechanism must likely exist.
FGFR3 Translocations in Bladder Cancer: Differential Sensitivity to HSP90 Inhibition Based on Drug Metabolism

Activating mutations and/or overexpression of FGFR3 are common in bladder cancer, making FGFR3 an attractive therapeutic target in this disease. In addition, FGFR3 gene rearrangements have recently been described that define a unique subset of bladder tumors. Here, a selective HSP90 inhibitor, ganetespib, induced loss of FGFR3-TACC3 fusion protein expression and depletion of multiple oncogenic signaling proteins in RT112 bladder cells, resulting in potent cytotoxicity comparable with the pan-FGFR tyrosine kinase inhibitor BGJ398. However, in contrast to BGJ398, ganetespib exerted pleiotropic effects on additional mitogenic and survival pathways and could overcome the FGFR inhibitor–resistant phenotype of FGFR3 mutant–expressing 97-7 and MHG-U3 cells. Combinatorial benefit was observed when ganetespib was used with BGJ398 both in vitro and in vivo. Interestingly, two additional FGFR3 fusion-positive lines (RT4 and SW480) retained sensitivity to HSP90 inhibitor treatment by the ansamycins 17-AAG and 17-DMAG yet displayed intrinsic resistance to ganetespib or AUY922, both second-generation resorcinol-based compounds. Both cell lines, compared with RT112, expressed considerably higher levels of endogenous UGT1A enzyme; this phenotype resulted in a rapid glucuronidation-dependent metabolism and subsequent efflux of ganetespib from SW780 cells, thus providing a mechanism to account for the lack of bioactivity. Implications: Pharmacologic blockade of the molecular chaperone HSP90 represents a promising approach for treating bladder tumors driven by oncogenic gene rearrangements of FGFR3. Furthermore, UDP-glucuronosyltransferase enzyme expression may serve as a predictive factor for clinical response to resorcinol-based HSP90 inhibitors. Mol Cancer Res; 12(7); 1042–54. ©2014 AACR.
The Land Ethic and Callicott's Ethical System (1980-2001): An Overview and Critique

This article analyzes the evolution of the land ethic re-presented by J. Baird Callicott over the last two decades under pressure from the charge of misanthropy and ecofascism. It also traces the development of Callicott? s own ethical system, and examines its most current phase both in itself and in relation to his other theoretical commitments, including his particular version of moral monism, and his communitarian critique of egalitarianism. It concludes that Callicott? s communitarianism is by itself insufficient to fund an adequate environmental ethic, and that for the sake of self-consistency he should either discard his moral monism or else further revise his ethical system.
Developing blended learning resources and strategies to support academic reading: a student‐centred approach

This article focuses on a blended learning curriculum development project, in which a student was prospectively engaged with teacher educators in developing resources designed to increase support for academic reading. Curriculum development took place at the University of Hertfordshire School of Education through the Change Academy for Blended Learning Enhancement (CABLE) project, which was developed through participation in the UK Higher Education Academy and Joint Information Systems Committee Pathfinder programme. Senior colleagues in the School and members of the University of Hertfordshire Blended Learning Unit, a Centre for Excellence in Teaching and Learning, provided strategic and operational support. The project evaluation framework was based on RUFDATA (reasons and purposes; uses; focus; data and evidence; audience; timing; and agency). The need for support for academic reading had been demonstrated through programme evaluation and review. Gaps in provision were identified following a survey to define the scope of Master's‐level reading and an audit of available resources. Resources and activities for accessing, interacting with and sharing reading materials were developed by teacher educators in consultation with the student (education practitioner) team member and a university information consultant. In addition to the student contribution throughout the project, other participants on the Continuing Professional Development (CPD) programme module contributed to evaluating the resources developed to support their reading. This project provides an example of a learner‐centred approach to programme development. Students' views were valued as part of the design process through identifying learning needs and then developing and trialling resources to support academic reading, and as part of the ongoing development and evaluation.
Histochemical and architectonic differentiation of zones of pretectal and collicular inputs to the pulvinar and dorsal lateral geniculate nuclei in the macaque

The pattern of acetylcholinesterase (AChE) reactivity was studied in the pulvinar and dorsal lateral geniculate nucleus (DLG) of the adult macaque monkey. Discrete islands of AChE reactivity were found that correlated precisely in location with the pattern of projections from the superior colliculus and pretectum. Specifically, AChE overlies terminal fields of superior colliculus projections in the DLG, in four foci in the medial and lateral pulvinar, and in several foci in the inferior pulvinar. All of these tectal projection areas have very high AChE reactivity such that they are easily distinguished. In addition, the pretectum projects to a specific focus in the lateral pulvinar that also has a very dense AChE histochemical reaction. A number of these AChE foci could be further distinguished from other areas in the pulvinar by myeloarchitectonic characteristics. Some of the foci in the lateral and inferior pulvinars could also be distinguished by unique cytoarchitectonic features (as seen with both Nissl and Golgi stains). In an attempt to determine the possible origin of a cholinergic input to the pulvinar, horseradish peroxidase (HRP) injections and choline acetyltransferase immunohistochemistry were also done. The results of this experiment indicate that the AChE reactivity seen in the midbrain projection zones to the thalamus may be due to the precise overlap of terminal projections from the brainstem cholinergic cell groups, Ch5, Ch6, and Ch8. These results, taken together, imply that there are several anatomically and histochemically distinct zones related to extre ageniculate pathways located within classically defined thalamic boundaries.
Depression and Anxiety among Rural Kikuyu in Kenya

depreciation results partly from the assumption that, in an area of the world where infectious and parasitic disease is known to be so common, viruses, bacteria, fungi, and parasites must be the most important hazards facing Africans' physical health and sense of wellbeing. The few studies (Giel and Van Luijk 1969; Mbanefo 1971; German 1972) that attempt to establish what proportion of persons reporting as patients at health care facilities are primarily psychiatric indicate that "psychiatric disorders are one of the com-
MicroRNAs: a macroview into focal segmental glomerulosclerosis.

Focal segmental glomerulosclerosis (FSGS) is a histologic lesion that characterizes a pattern of injury to the kidney with numerous causes, for example, podocyte gene mutations, circulating factors, and certain toxins. Clinically, FSGS is often associated with nephrotic syndrome. As is the case with most kidney diseases, glomerular filtration rate and albuminuria are the primary biomarkers to diagnose, stage, and potentially monitor treatment of patients with FSGS, absent definitive treatments for the cause of disease. Kidney biopsies provide additional information. However, these measures are insufficient, especially whenmonitoring response to therapy and disease progression, and novel biomarkers are needed, not only to improve diagnosis and staging, but also for monitoring therapeutic responses. A report byZhang et al in this issue of AJKD directly addresses this issue by profiling plasma from a cohort of patients with FSGS and identify a circulating microRNA, microRNA-186, as a candidate biomarker for FSGS. MicroRNAs (miRNAs or miRs) are naturally occurring RNAs that regulate gene expression but do not code for proteins themselves. Mature miRNAs are only approximately 22 nucleotides in length and associate with a group of RNA-degrading proteins into an RNA-induced silencing complex (RISC) that mediates degradation of their target messenger RNA (mRNA) transcripts to modulate protein expression in cells. miRNAs sequence-specifically bind the 30untranslated regions of target mRNAs, either perfectly or imperfectly, where they promote mRNA degradation or suppress mRNA translation, thus regulating cellular functions. Because individual miRNAs can target multiple mRNAs in a signaling network, one miRNA can exert control over many cellular pathways. miRNAs and other noncoding RNA molecules have been shown to modulate protein expression in a number of additional ways, including by association with DNA and histone-modifying proteins, transcription factors, and other proteins.
Low-Power chip-scale Rubidium plasma light source for miniature atomic clocks

We present the development, testing and characterization of a low-power chip-scale Rubidium (Rb) plasma light source designed to serve for optical pumping in miniature atomic clocks. The technique used is electrodeless capacitively coupled plasma (CCP) discharge, driven in a micro-fabricated Rb vapor cell. The device is electrically driven at frequencies between 1 and 36 MHz to emit 140 µW of stable optical power while coupling < 6 mW of electrical power to the discharge cell. To our knowledge this is the first reported Rb plasma emitted from a chip-scale device.
Comparison of Classifiers for Decoding Sensory and Cognitive Information from Prefrontal Neuronal Populations

Decoding neuronal information is important in neuroscience, both as a basic means to understand how neuronal activity is related to cerebral function and as a processing stage in driving neuroprosthetic effectors. Here, we compare the readout performance of six commonly used classifiers at decoding two different variables encoded by the spiking activity of the non-human primate frontal eye fields (FEF): the spatial position of a visual cue, and the instructed orientation of the animal's attention. While the first variable is exogenously driven by the environment, the second variable corresponds to the interpretation of the instruction conveyed by the cue; it is endogenously driven and corresponds to the output of internal cognitive operations performed on the visual attributes of the cue. These two variables were decoded using either a regularized optimal linear estimator in its explicit formulation, an optimal linear artificial neural network estimator, a non-linear artificial neural network estimator, a non-linear naïve Bayesian estimator, a non-linear Reservoir recurrent network classifier or a non-linear Support Vector Machine classifier. Our results suggest that endogenous information such as the orientation of attention can be decoded from the FEF with the same accuracy as exogenous visual information. All classifiers did not behave equally in the face of population size and heterogeneity, the available training and testing trials, the subject's behavior and the temporal structure of the variable of interest. In most situations, the regularized optimal linear estimator and the non-linear Support Vector Machine classifiers outperformed the other tested decoders.
Metacognitive Experience and Transfer of Logical Reasoning

The experiments examine the influence of metacognitive experience on the transfer of logical processes in a problem solving setting. Subjects were presented with two versions of Wason's (1966) selection task. Although they were able to perform successfully on the concrete tasks (following a minimal explanation of the correct solution on an initial trial), the majority were not able to transfer a successful method to the abstract tasks. Verbalization during, or following, the concrete tasks produced substantial transfer effects however. It is suggested that verbalization may lead to an increased awareness of past behaviour, particularly of those aspects necessary for successful solution.
Antibiofilm agents and implant-related infections in orthopaedics: where are we?

Abstract Orthopaedics is currently the largest market of biomaterials worldwide and implant-related infections, although relatively rare, remain among the first reasons for joint arthroplasty and osteosynthesis failure. Bacteria start implant infection by adhering to biomaterials and producing biofilms, which represent a major reason for bacterial persistence, in spite of antibiotic treatment and host’s defence. In the last two decades, a number of different antibiofilm agents have been studied and both in vitro and in vivo results appear now promising, even if their effective role in orthopaedics remains to be assessed. In this review, we introduce an original classification of antibiofilm agents, based on their mechanism of action and examine the available data concerning their possible application to orthopaedic implant-related infections. Molecules that interfere with biofilm production (biofilm prevention agents) include anti-adhesion compounds, quorum sensing inhibitors, non-steroideal anti-inflammatory drugs, and antimicrobial peptides; N-acetylcysteine and specific enzymes promise the greatest therapeutic possibilities by disrupting established biofilms (biofilm disrupting agents). The identification of antimicrobials able to bypass the biofilm barrier (biofilm bypassing agents), and antibiofilm vaccines are further strategies aimed to reduce the impact of biofilm-related infections, opening new pathways in controlling implant-related infections. However, this review shows that still insufficient knowledge is currently available as to regard the efficacy and safety of the investigated antibiofilm strategies to treat infection that involve bone tissue and biomaterials commonly implanted in orthopaedics, pointing out the need for further research in this promising field.
A Perceptual No-Reference Blockiness Metric for JPEG Images

In this paper 1 we present a novel no-reference (NR) metric to measure block impairment (blockiness) in JPEGcoded images. The proposed metric integrates several key human visual sensitivity factors such as edge amplitude, edge length, background activity and background luminance to evaluate the effect of block edge impairment on perceived image quality. The subjective test results of our metric is compared with the Wang-Bovik’s NR blockiness metric [9]. The results show that the proposed metric correlates well with the mean opinion score (MOS) than WangBovik’s blockiness metric. Further this metric can be extended to predict the quality of the MPEG/H.26x compressed videos.