Miracle-dz/UniFAR-FTUs huggingface dataset:
Semantic and Phonological Ability to Adjust Recoding: A Unique Correlate of Word Reading Skill?

ABSTRACT This study addresses whether reading involves a process termed semantic and phonological ability to adjust recoding (SPAAR). It was hypothesized that SPAAR helps readers link inaccurate pronunciations to lexical entries (e.g., spynitch to spinach). Psychometric properties of the Mispronunciation Correction Task (MCT), a measure of SPAAR, were investigated using a sample of 206 elementary-age children. The 25-item MCT appeared to measure a single construct, and the items discriminated well across the range of ability. Based on a sample of 94 children, construct validity analyses indicated that phonological awareness and decoding skill predicted MCT performance. Hierarchical regressions were used to test the relationship between SPAAR and word reading. After controlling for other skills, SPAAR showed a relationship with both timed and untimed word reading. Phonological awareness did not. These data suggest that SPAAR may be a reading-related ability involving phonological processing and some form of semantic processing.
The Variation of Magnesium Depletion with Line-of-Sight Conditions

In this paper we report on the gas-phase abundance of singly ionized magnesium (Mg II) in 44 lines of sight, using data from the Hubble Space Telescope (HST). We measure Mg II column densities by analyzing medium- and high-resolution archival Space Telescope Imaging Spectrograph (STIS) spectra of the 1240 Å doublet of Mg II. We find that Mg II depletion is correlated with many line-of-sight parameters [e.g., f(H2), EB-V, EB-V/r, AV, and AV/r] in addition to the well-known correlation with ⟨nH⟩. These parameters should be more directly related to dust content and thus have more physical significance with regard to the depletion of elements such as magnesium. We examine the significance of these additional correlations as compared to the known correlation between Mg II depletion and ⟨nH⟩. While none of the correlations are better predictors of Mg II depletion than ⟨nH⟩, some are statistically significant even assuming fixed ⟨nH⟩. We discuss the ranges over which these correlations are valid, their strength at fixed ⟨nH⟩, and physical interpretations.
Multibeam Selection for Indoor MIMO Systems: Two Cases of Study

The performance of multiple-input multiple-output (MIMO) systems using beam selection is investigated in this paper. Based on the results of a channel sounding campaign carried out at the University of Manitoba for line-of-sight (LOS) and non-line-of-sight (NLOS) scenarios, it was possible to contrast the results of transmitter, receiver and joint beam selection in rich scattering environments. The channel was characterized in the 1-2.4 GHz frequency band with a multipath delay resolution better than 5.8 ns. The beam selection was performed by exhaustive search method. The results led us to important conclusions regarding the beam selection procedure and its potential to improve the indoor channel capacity. In LOS, the single input single output (SISO) system that favours the maximum power direction of arrival (DOA) maximizes the capacity. Capacity improvements are observed by increasing the number of receiver beams (RBs) only at high signal-to-noise ratios (SNRs) for omnidirectional transmission. The best performance in transmitter beam selection in LOS is observed by increasing the number of transmitter beams (TBs) for high SNRs. In the case of NLOS, the capacity performance is improved when more than a single beam is used in either, transmitter or receiver side. The joint transmitter-receiver beam selection exhibits best capacity performance only for large SNRs in LOS while the SISO systems outperforms any joint beam selection alternative for low SNRs. In contrast, in NLOS environments, the use of joint beam selection shows a constant capacity performance improvement starting from lower SNR than in the LOS case
Antiviral Activity of a Small Molecule Deubiquitinase Inhibitor Occurs via Induction of the Unfolded Protein Response

Ubiquitin (Ub) is a vital regulatory component in various cellular processes, including cellular responses to viral infection. As obligate intracellular pathogens, viruses have the capacity to manipulate the ubiquitin (Ub) cycle to their advantage by encoding Ub-modifying proteins including deubiquitinases (DUBs). However, how cellular DUBs modulate specific viral infections, such as norovirus, is poorly understood. To examine the role of DUBs during norovirus infection, we used WP1130, a small molecule inhibitor of a subset of cellular DUBs. Replication of murine norovirus in murine macrophages and the human norovirus Norwalk virus in a replicon system were significantly inhibited by WP1130. Chemical proteomics identified the cellular DUB USP14 as a target of WP1130 in murine macrophages, and pharmacologic inhibition or siRNA-mediated knockdown of USP14 inhibited murine norovirus infection. USP14 is a proteasome-associated DUB that also binds to inositol-requiring enzyme 1 (IRE1), a critical mediator of the unfolded protein response (UPR). WP1130 treatment of murine macrophages did not alter proteasome activity but activated the X-box binding protein-1 (XBP-1) through an IRE1-dependent mechanism. In addition, WP1130 treatment or induction of the UPR also reduced infection of other RNA viruses including encephalomyocarditis virus, Sindbis virus, and La Crosse virus but not vesicular stomatitis virus. Pharmacologic inhibition of the IRE1 endonuclease activity partially rescued the antiviral effect of WP1130. Taken together, our studies support a model whereby induction of the UPR through cellular DUB inhibition blocks specific viral infections, and suggest that cellular DUBs and the UPR represent novel targets for future development of broad spectrum antiviral therapies.
Peg-Interferon Plus Ribavirin with or without Boceprevir or Telaprevir for HCV Genotype 1: A Meta-Analysis on the Role of Response Predictors

Background & aim To compare the efficacy of pegylated-interferon (Peg-IFN) α-2a or α-2b and ribavirin given as dual therapy versus triple therapy (Peg-IFN and ribavirin plus boceprevir or telaprevir) in patients with HCV-1 chronic hepatitis naïve for anti-HCV therapy or relapsers to dual therapy in relation to the presence of constitutional, clinical and virological predictors of treatment response. Methods Included in the meta-analysis were studies meeting these criteria: original data from randomized trials on the efficacy of dual versus triple therapy in therapy-naïve patients or relapsers; at least one primary outcome clearly defined: sustained virological response in patients with or without rapid virological response (RVR), with genotype 1a or 1b, low or high HCV load, IL28-B CC or non-CC genotype, mild or severe fibrosis; odds ratio estimates of relative risk (RR) and 95% confidence intervals; English language; and published up to the end of June 2013. Results Seven original studies met the inclusion criteria, allowing a meta-analysis on 3,652 patients. Triple therapy was more effective than dual, regardless of IL-28B genotype, HCV sub-genotype, liver fibrosis, and baseline HCV load. In 1,045 patients who achieved RVR, SVR was more frequently achieved with dual therapy (RR = 1.11; p = 0.002) than triple. The same results were achieved when only the therapy-naïve patients were considered. Conclusions Triple therapy provides a significantly higher SVR rate than dual therapy, but dual therapy obtains a significantly higher SVR rate in patients with RVR. The data stress the clinical importance of a 4-week lead-in phase in direct-acting antiviral-based treatment.
Three-year evolution of physical fitness and bmi in schoolchildren aged 12-16 years with extreme bmi

The aim of this study was to investigate a three-year development in BMI and physical fitness of schoolchildren aged 12-16 years with extreme weight status. Taiwan Physical Fitness Test Battery, assessing aerobic fitness (1600-meter walk/run test), power (standing long jump), muscular endurance (sit-up), and flexibility (sit-and-reach) in 16,945 boys, was implemented in September from the year 2006 till 2008. Overweight and underweight were defined by the baseline BMI data values that fall within the highest and lowest 5% of their age population, whereas the BMI data values that fall within one standard deviation of the mean was considered “normal” in this study. The results showed that BMI of schoolchildren in 2006 was ~2–3 kg/m 2 above the national average reported in 1993. All physical fitness components in the overweight group were substantially poorer than those in the normal group. Yet, these fitness parameters were improved over the three years in all groups. BMI in the underweight group increased at a faster rate than that in the normal and overweight groups. No difference was found in the jumping distance between the underweight and normal groups. Aerobic fitness in the underweight group was superior but flexibility and muscular endurance were slightly lower than those in the normal group. BMI of Taiwan schoolchildren increased substantially from 1993 to 2006 but leveled off from 2006 to 2008. Underweight schoolchildren during the growing period should not a priori be considered as physically weaker or unfit individuals.
Understanding Suicidal Behavior Among Latin Adolescent Girls Living in the United States

Suicide in adolescents between the age of 10 and 24 years old is the second cause of death in the United States. This rate differentiates by ethnic and racial groups within the same country; Latino/Hispanic adolescent girls have the highest rate of suicide behavior. Considering that Latino/Hispanic is the fastest growing minority group in the nation, with an expected population of 30% by 2060, this issue should be a public health priority. This paper answers the following question: what are the conditions operating among Latin adolescent girls living in the United States that cause significantly higher suicidal behavior rates in the U.S. and compared with their peers in Latin American countries? And, how adequate are treatments such as Dialectical Behavioral Therapy and prevention programs in tackling the specific risk factors affecting this population? The paper is divided into five chapters; the first four are based on a comprehensive literature review of statistics of suicide, risk and protective factors, treatment, and prevention programs. The last chapter offers an analysis of the sociological phenomenon of suicidal behavior in this population and three brief narratives of attempters and non-­‐attempters. Studies show that subjective distress, familism and immigration issues are the key risk factors of suicidal behavior in Latina adolescent girls. Understanding the risk factors is key in order to design promotion and prevention programs that are culturally relevant and that can have a positive impact in the reduction of this alarming phenomenon.
I-O Practice in Action: Solving the Leadership Potential Identification Challenge in Organizations

In 2008, we saw an emerging business need to accurately identify and develop individuals early in their careers who have the potential to be effective leaders in later organizational positions. We decided early on to take a comprehensive and systematic approach to the challenge in order to build effective solutions with real organizational impact that are sustainable over time. We knew that this was a complex problem and that there was little agreement in industrial–organizational (I-O) psychology on how to approach this critical business need and what approaches would be most effective. Since then, we moved through the following process stages to arrive at effective solutions that are now being used in numerous organizations.
accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca2+ pump SERCA1

When wild-type zebrafish embryos are touched at 24 hours post-fertilization (hpf), they typically perform two rapid alternating coils of the tail. By contrast, accordion (acc) mutants fail to coil their tails normally but contract the bilateral trunk muscles simultaneously to shorten the trunk, resulting in a pronounced dorsal bend. Electrophysiological recordings from muscles showed that the output from the central nervous system is normal in mutants, suggesting a defect in muscles is responsible. In fact, relaxation in acc muscle is significantly slower than normal. In vivo imaging of muscle Ca2+ transients revealed that cytosolic Ca2+ decay was significantly slower in acc muscle. Thus, it appears that the mutant behavior is caused by a muscle relaxation defect due to the impairment of Ca2+ re-uptake. Indeed, acc mutants carry a mutation in atp2a1 gene that encodes the sarco(endo)plasmic reticulum Ca2+-ATPase 1 (SERCA1), a Ca2+ pump found in the muscle sarcoplasmic reticulum (SR) that is responsible for pumping Ca2+ from the cytosol back to the SR. As SERCA1 mutations in humans lead to Brody disease, an exercise-induced muscle relaxation disorder, zebrafish accordion mutants could be a useful animal model for this condition.
Duplication and adaptive evolution of the chalcone synthase genes of Dendranthema (Asteraceae).

Chalcone synthase (CHS) is a key enzyme in the biosynthesis of flavonoids, which are important for the pigmentation of flowers and act as attractants to the pollinators. Genes encoding CHS constitute a multigene family in which the copy number varies among plant species and functional divergence appears to have occurred repeatedly. Plants of the Dendranthema genus have white, yellow, and pink flowers, exhibiting considerable variation in flower color. In this article, 18 CHS genes from six Dendranthema species were sequenced. Two of them were found to be pseudogenes. The functional Dendranthema CHS genes formed three well-supported subfamilies: SF1, SF2, and SF3. The inferred phylogeny of the CHS genes of Dendranthema and Gerbera suggests that those genes originated as a result of duplications before divergence of these two genera, and the function of Dendranthema CHS genes have diverged in a similar fashion to the Gerbera CHS genes; i.e., the genes of SF1 and SF3 code for typical CHS enzymes expressed during different stages of development, whereas the genes of SF2 code for another enzyme that is different from CHS in substrate specificity and reaction. Relative rate tests revealed that the Dendranthema CHS genes significantly deviated from clocklike evolution at nonsynonymous sites. Maximum likelihood analysis showed that the nonsynonymous-synonymous (omega = d(N)/d(S)) rate ratio for the lineage ancestral to SF2 was much higher than for other lineages, with some sites having a ratio well above one. Positive selective pressure appears to have driven the divergence of SF2 from SF1 and SF3.
Evaluation of methods used in assessing the accuracy of InSAR-derived DEMs

Interferometric SAR has been widely used as a source of data for construction of Digital Elevation Models (DEMs) especially since the operation of ERS-2 (launched in July 1995) in tandem with ERS-1. In most publications describing the accuracy of such DEM a single figure, the Root Mean Square (RMS) error is used irrespective of the extent and terrain characteristics of the study area. System characteristics are also important factors to be considered in reporting the achievable accuracy of InSAR DEM. Some reports mention system parameters and terrain characteristics, but the spatial distribution of the error with respect to any influencing factor, such as coherence or terrain slope, are not generally reported. Understanding the spatial distribution of the elevation error is important in assessing the quality of InSAR DEMs in order to avoid any misrepresentation of the potentials and limitations of the technique. In this study, different methods of reporting the RMS error are attempted and assessed. Plotting the cumulative RMS against the percentage of pixels reveals the presence of anomalies. The first derivative and the second derivative of the RMS curve reveal the location of those anomalies that introduce high errors to the final RMS value. RMS error for a regular grid gives an idea of the different accuracy level one would achieve if different image sizes or different test site locations for same image size were chosen for the study. Since it is critical to understand the factors influencing the height error, the spatial distribution of error is analysed to determine its correlation with local slope of the terrain and spatial coherence of the interferometric data. A stratified RMS approach is used to evaluate the spatial relationship of the height error with local slope and coherence. The coherence-stratification shows positive relation with the accuracy of height estimation i.e. negative relation with the RMS error value. But the overall coherence value of the InSAR pair does not show any relationship with the overall achievable accuracy of the DEM. The local slope-stratification does not show any relation with the spatial distribution of the elevation error.
Alphavirus Mutator Variants Present Host-Specific Defects and Attenuation in Mammalian and Insect Models

Arboviruses cycle through both vertebrates and invertebrates, which requires them to adapt to disparate hosts while maintaining genetic integrity during genome replication. To study the genetic mechanisms and determinants of these processes, we use chikungunya virus (CHIKV), a re-emerging human pathogen transmitted by the Aedes mosquito. We previously isolated a high fidelity (or antimutator) polymerase variant, C483Y, which had decreased fitness in both mammalian and mosquito hosts, suggesting this residue may be a key molecular determinant. To further investigate effects of position 483 on RNA-dependent RNA-polymerase (RdRp) fidelity, we substituted every amino acid at this position. We isolated novel mutators with decreased replication fidelity and higher mutation frequencies, allowing us to examine the fitness of error-prone arbovirus variants. Although CHIKV mutators displayed no major replication defects in mammalian cell culture, they had reduced specific infectivity and were attenuated in vivo. Unexpectedly, mutator phenotypes were suppressed in mosquito cells and the variants exhibited significant defects in RNA synthesis. Consequently, these replication defects resulted in strong selection for reversion during infection of mosquitoes. Since residue 483 is conserved among alphaviruses, we examined the analogous mutations in Sindbis virus (SINV), which also reduced polymerase fidelity and generated replication defects in mosquito cells. However, replication defects were mosquito cell-specific and were not observed in Drosophila S2 cells, allowing us to evaluate the potential attenuation of mutators in insect models where pressure for reversion was absent. Indeed, the SINV mutator variant was attenuated in fruit flies. These findings confirm that residue 483 is a determinant regulating alphavirus polymerase fidelity and demonstrate proof of principle that arboviruses can be attenuated in mammalian and insect hosts by reducing fidelity.
MODELING OF TENSILE STRESS-STRAIN RELATION OF PSEUDO STRAIN HARDENING CEMENTITIOUS COMPOSITES

This study proposes a new comprehensive theoretical approach for predicting tensile stress-strain relation of Random Short Fiber Reinforced Cement Composites (RSFRCC) showing Pseudo Strain Hardening (PSH). This approach is grounded on solid basis of micromechanics, which describes PSH phenomenon in terms of constitutive properties of fiber, matrix, and fiber/matrix interface. The proposed modeling requires theoretical treatment of inelastic strain due to multiple cracking. This modeling is achieved by employing a probabilistic description of initial flaw size distribution, which should be known for predicting stress-strain relation. This study proposes a practical method for this identification using the tensile test result of a reference composite. Comparison with test data indicates that the proposed model is capable of reasonably reproducing stress-strain relation of “similar” composites. Such composites have configuration (matrix mix proportion, mixing process and age) similar to the reference one but different in fiber volume fraction and fiber length. Finally, it is indicated that the proposed theory can be a potentially powerful tool for tailoring composites in order to satisfy targeted structural performance. 1 Sr. Res. Engr. , Kajima Technical Research Institute, 2-19-1 Tobitakyu, Chofu-shi, Tokyo 182-0036, Japan. 2 Optimal Computer Aided Engineering, Inc., 39555 Orchard Hill Place, Novi, MI 48375 3 Prof. and Dir. , ACE-MRL, Dept. of Civ. and Envir. Engrg. , Univ. of Michigan, Ann Arbor, MI 48109-2125.
Journal of Internet Banking and Commerce Factors Affecting the Adoption of Internet Banking amongst Iium' Students: a Structural Equation Modeling Approach (sem)

This article examines the factors that determine the internet banking adoption amongst International Islamic University Malaysia (IIUM) and its causal effects using a theoretical model based on the Technology Acceptance Model (TAM). The research model consists of four exogenous latent constructs, namely, awareness, perceived usefulness, trust and perceived risk and endogenous latent construct namely Internet banking adoption. Data relating to constructs were collected from 200 university's students in (IIUM) and subjected to structural Equation Modeling (SEM) analysis. Confirmatory Factor Analysis (CFA) was performed to examine the reliability, construct validity, convergent validity and goodness of fit of structural models and measurement models. The hypothesized structural model fits the data well. The results show that the significant factor that leads to the adoption of internet banking is perceived usefulness but awareness, trust and risk have negative significant towards the use of internet banking.
Inflammatory Stress Increases Hepatic CD36 Translational Efficiency via Activation of the mTOR Signalling Pathway

Inflammatory stress is an independent risk factor for the development of non-alcoholic fatty liver disease (NAFLD). Although CD36 is known to facilitate long-chain fatty acid uptake and contributes to NAFLD progression, the mechanisms that link inflammatory stress to hepatic CD36 expression and steatosis remain unclear. As the mammalian target of rapamycin (mTOR) signalling pathway is involved in CD36 translational activation, this study was undertaken to investigate whether inflammatory stress enhances hepatic CD36 expression via mTOR signalling pathway and the underlying mechanisms. To induce inflammatory stress, we used tumour necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) stimulation of the human hepatoblastoma HepG2 cells in vitro and casein injection in C57BL/6J mice in vivo. The data showed that inflammatory stress increased hepatic CD36 protein levels but had no effect on mRNA expression. A protein degradation assay revealed that CD36 protein stability was not different between HepG2 cells treated with or without TNF-α or IL-6. A polysomal analysis indicated that CD36 translational efficiency was significantly increased by inflammatory stress. Additionally, inflammatory stress enhanced the phosphorylation of mTOR and its downstream translational regulators including p70S6K, 4E-BP1 and eIF4E. Rapamycin, an mTOR-specific inhibitor, reduced the phosphorylation of mTOR signalling pathway and decreased the CD36 translational efficiency and protein level even under inflammatory stress resulting in the alleviation of inflammatory stress-induced hepatic lipid accumulation. This study demonstrates that the activation of the mTOR signalling pathway increases hepatic CD36 translational efficiency, resulting in increased CD36 protein expression under inflammatory stress.