Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimisation of process parameters for lattice structures

Purpose – This paper aims to develop a set of process parameters tailored for lattice structures and test them against standard process (SP) parameters. Selective laser melting (SLM) is a commonly known and established additive manufacturing technique and is a key technology in generating intricately shaped lattice structures. However, SP parameters used in this technology have building time and accuracy disadvantages for structures with a low area-to-perimeter ratio, such as thin struts. Design/methodology/approach – In this research work, body-centred cubic structure specimens are manufactured using adapted process parameters. Central to the adapted process parameters is the positioning of the laser beam, the scan strategy and the linear energy density. The specimens are analysed with X-ray micro-computed tomography for dimensional accuracy. The final assessment is a comparison between specimens manufactured using adapted process parameters and those using SP parameters. Findings – Standard parameters f.
Bias Against Novelty in Science: A Cautionary Tale for Users of Bibliometric Indicators

Research which explores unchartered waters has a high potential for major impact but also carries a high uncertainty of having minimal impact. Such explorative research is often described as taking a novel approach. This study examines the complex relationship between pursuing a novel approach and impact. We measure novelty by examining the extent to which a published paper makes first time ever combinations of referenced journals, taking into account the difficulty of making such combinations. We apply this newly developed measure of novelty to a set of one million research articles across all scientific disciplines. We find that highly novel papers, defined to be those that make more (distinct) new combinations, have more than a triple probability of being a top 1% highly cited paper when using a sufficiently long citation time window to assess impact. Moreover, follow-on papers that cite highly novel research are themselves more likely to be highly cited. However, novel research is also risky as it has a higher variance in the citation performance. These findings are consistent with the “high risk/high gain” characteristic of novel research. We also find that novel papers are typically published in journals with a lower than expected Impact Factor and are less cited when using a short time window. Our findings suggest that science policy, in particular funding decisions which are over reliant on traditional bibliometric indicators based on short-term direct citation counts and Journal Impact Factors, may be biased against novelty.
Prediction of the aerobic demand of walking in children.

PURPOSE The purpose of this study was to develop a generalized equation to predict VO2 during level treadmill walking in young boys and girls. METHODS On an annual basis from ages 6 to 10, 23 able-bodied children (14 girls, 9 boys) completed six 5-min walking bouts at speeds ranging from 40.2 to 107.2 m x min(-1). Before testing, each child received 60 min of treadmill walking practice. During the last 2 min of each walking trial, a 2-min sample of expired gas was collected in a meteorological balloon and analyzed to determine VO2. RESULTS Stepwise regression analyses indicated that the following equation was best suited to predict walking VO2: VO2 = 24.852 + 0.003214 (walking speed in m x min(-1))2 - 0.995 (age in yr) - 0.263 (walking speed); R = 0.95; SEE = 1.74 mL x kg(-1) x min(-1). Bland-Altman analysis revealed that 95% of the differences between actual and predicted VO2 values fell within a range of 3.39 to -3.43 mL x kg(-1) x min(-1). CONCLUSION We conclude that VO2 during level treadmill walking can be predicted accurately in healthy young children.
Automatic synthesis of interfaces between incompatible protocols

At the system level, reusable Intellectual Property (or IP) blocks can be represented abstractly as blocks that exchange messages. The concrete implementations of these IP blocks must exchange the messages through complex signaling protocols. Interfacing between IP that use different signaling protocols is a tedious and error prone design task. We propose using regular expression based protocol descriptions to show how to map the message onto a signaling protocol. Given two protocols, an algorithm is proposed to build an interface machine. We have implemented our algorithm in a program named PIG that synthesizes a Verilog implementation based on a regular expression protocol description.
Narrow Band Region-Based Active Contours Model for Noisy Color Image Segmentation

A narrow band active contour model for color image segmentation is proposed, which applies local statistics to improve the robustness against noise. The crux of our approach is to use intensity mean of local region to define the force function within a level set framework, within which a narrow band is implemented to further improve the computational efficiency. In addition, the image is segmented from channel-to-channel, which shows superior performance when the intensities of the object and background are similar. Furthermore, a multichannel segmentation combination method is used to integrate the information of multiple level sets. The proposed model has been applied to both synthetic and real images with expected results, and the comparison with the state-of-the-art approaches demonstrates the accuracy and superiority of our approach.
Tube thoracostomy training with a medical simulator is associated with faster, more successful performance of the procedure

Objective Tube thoracostomy (TT) is a commonly performed intensive care procedure. Simulator training may be a good alternative method for TT training, compared with conventional methods such as apprenticeship and animal skills laboratory. However, there is insufficient evidence supporting use of a simulator. The aim of this study is to determine whether training with medical simulator is associated with faster TT process, compared to conventional training without simulator. Methods This is a simulation study. Eligible participants were emergency medicine residents with very few (≤3 times) TT experience. Participants were randomized to two groups: the conventional training group, and the simulator training group. While the simulator training group used the simulator to train TT, the conventional training group watched the instructor performing TT on a cadaver. After training, all participants performed a TT on a cadaver. The performance quality was measured as correct placement and time delay. Subjects were graded if they had difficulty on process. Results Estimated median procedure time was 228 seconds in the conventional training group and 75 seconds in the simulator training group, with statistical significance (P=0.040). The difficulty grading did not show any significant difference among groups (overall performance scale, 2 vs. 3; P=0.094). Conclusion Tube thoracostomy training with a medical simulator, when compared to no simulator training, is associated with a significantly faster procedure, when performed on a human cadaver.
DEX METHODOLOGY : THIRTY THREE YEARS OF QUALITATIVE MULTI-ATTRIBUTE MODELING

DEX is a qualitative multi-attribute decision modeling methodology, which is based on an integration of multicriteria decision modeling with rule-based expert systems. The method was conceived 33 years ago. In its lifespan, it has been implemented in a wide range of computer programs that have been used in hundreds of practical applications. In this paper we report on its main methodological concepts, contributions to the theory and practice of decision support, and present a history of its development and evolution.
Usefulness of salivary alpha amylase as a biomarker of chronic stress and stress related oral mucosal changes – a pilot study

Introduction: Salivary biomarkers are suggested to provide a reliable, noninvasive and objective measurement of chronic psychosocial stress and helps in assessment of pivotal role of stress in causation or precipitation of multitude of health problems. Objectives: To evaluate the usefulness of salivary alpha amylase activity as an objective indicator of chronic stress and to find out any correlation between stress- related mucosal complaints and its levels. Study Design: Study was conducted among 50 subjects suffering from chronic stress related problems and 50 non-stressed individuals who were screened with a psychometric questionnaire. Brief case history and oral examination was carried out and about one ml of unstimulated saliva was collected. Salivary alpha amylase levels estimated were compared between study and control group and between subjects with and without oral mucosal changes using non parametric Mann Whitney U test. Results: There was statistically significant higher salivary alpha amylase levels in study group (p =.002) and salivary alpha amylase between the oral mucosal complaints group and without oral mucosal complaints group within the total study population were found to be statistically significant (p=0.045). Conclusions: Salivary amylase activity increases in patients with chronic psychosocial stress and may be used as a biomarker of chronic stress, but it may not be an indicator to suggest the development of stress related oral mucosal changes. Key words:Salivary biomarker, salivary alpha amylase, psychosocial stress, sympathetic nervous system, oral mucosal changes.
Economic Examination of Cefoperazone Therapy

Medical records of 1137 patients from 35 hospitals were reviewed to examine the total cost of care for patients receiving cefoperazone as initial therapy compared to a control group receiving alternative agents. The direct costs of care measurable through a retrospective review of patient records were examined, including the cost of antibiotic acquisition, drug administration, laboratory testing, and room and board. Results of a regression analysis show that cefoperazone as initial therapy is associated with lower costs for all factors studied except acquisition cost. Antibiotic acquisition averaged $24 per patient mora for the cefoperazone group (p < 0.01). However, for cefoperazone patients drug administration was $63 less (p <0.0001), laboratory testing costs averaged $9 less (p = 0.22), and costs associated with room and board charges were $80 less (p = 0.40). Total costs averaged $3073 per cefoperazone patient and $3228 per control patient (p = 0.20). These data suggest that the previously accepted definitions of antimicrobial costs (i.e., cost per gram, cost per dose, cost per day) may no longer be adequate in this era of cost containment. In order to make sound clinical decisions with lowest total costs, practitioners should identify how and where costs are incurred.
Time-dependent injection as a model for rapid blazar flares

Time-dependent injection can cause non-linear cooling effects, which lead to a faster energy loss of the electrons in jets. The most obvious result is the appearance of unique breaks in the SED, which would normally be attributed to a complicated electron distribution. The knowledge of the observation time and duration is important to interpret the observed spectra, because of the non-trivial evolution of the SED. Intrinsic gamma-gamma absorption processes in the emission region are only of minor importance.
Calibrating Redshift Distributions beyond Spectroscopic Limits with Cross-Correlations

We describe a new method that can measure the true redshift distribution of any set of objects that are studied only photometrically. Measuring the angular cross-correlation between objects in the photometric sample with objects in some spectroscopic sample as a function of the spectroscopic z, along with other, standard correlation measurements, provides sufficient information to reconstruct the redshift distribution of the photometric sample. The spectroscopic sample need not resemble the photometric sample in galaxy properties, but must fall within its sky coverage. We test this hybrid, photometric-spectroscopic cross-correlation technique with Monte Carlo simulations based on realistic error estimates (including sample variance). The rms errors in recovering both the mean redshift and σ of the redshift distribution for a single photometric redshift bin with true distribution given by a Gaussian are 1.4 × 10−3(σz/0.1)(Σp/10)−0.3(dNs/dz/25,000)−1/2, where σz is the true Gaussian σ , Σp is the surface density of the photometric sample in galaxies arcmin −2, and dNs/dz is the number of galaxies with a spectroscopic redshift per unit z. We test the impact of non-Gaussian redshift outliers and of systematic errors due to unaccounted-for bias evolution, errors in measuring autocorrelations, photometric zero-point variations, or mistaken cosmological assumptions, and find that none will dominate measurement uncertainties in reasonable scenarios. The true redshift distributions of even arbitrarily faint photometric samples may be determined to the precision required by proposed dark energy experiments (Δ⟨z⟩ ≲ 3 × 10−3 at z ∼ 1) with this method.
Right- and left-sided colon cancer – clinical and pathological differences of the disease entity in one organ

Introduction Some researchers suggest that cancers located in the right vs. the left side of the colon are different and they can be regarded as distinct disease entities. The aim of this study was to analyze differences in clinical, epidemiological and pathological features of patients with right-sided (RCC) and left-sided (LCC) colon cancer. Material and methods One thousand two hundred and twenty-four patients were operated on due to colorectal cancer. A group of 477 patients (254 women, mean age 65.5 ±11 for the whole group) with colon cancer was included (212 RCC vs. 265 LCC). Results Right colon cancer patients were older (67.8 ±11.3 vs. 63.2 ±11.2; p = 0.0087). Left colon cancer patients underwent surgery for urgent indications more often (17.0% vs. 8.5%; p = 0006). Tumor diameter was greater in the RCC group (55 ±60 mm vs. 38 ±21 mm; p = 0.0003). Total number of removed lymph nodes was higher in the RCC group (11.7 ±6 vs. 8.3 ±5; p = 0.0001). Lymph node ratio was higher in the LCC group (0.45 ±0.28 vs. 0.30 ±0.25; p = 0.0063). We found a strong positive correlation between tumor diameter and the number of removed lymph nodes in the LCC group (r = 0.531). Conclusions These differences may result from the fact that RCC patients are diagnosed at an older age. The smaller number of removed lymph nodes in LCC patients may result in incorrect staging. It is still necessary to find other biological dissimilarities of adenocarcinoma located on different sides of the colon.
Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles

Certain properties of the highly specialized synaptic transmitter vesicles are shared by constitutively occurring vesicles. We and others have thus identified a cDNA in various nonneuroendocrine cell types of rat and human that is related to synaptophysin, one of the major synaptic vesicle membrane proteins, which we termed pantophysin. Here we characterize the gene structure, mRNA and protein expression, and intracellular distribution of pantophysin. Its mRNA is detected in murine cell types of nonneuroendocrine as well as of neuroendocrine origin. The intron/exon structure of the murine pantophysin gene is identical to that of synaptophysin except for the last intron that is absent in pantophysin. The encoded polypeptide of calculated mol wt 28,926 shares many sequence features with synaptophysin, most notably the four hydrophobic putative transmembrane domains, although the cytoplasmic end domains are completely different. Using antibodies against the unique carboxy terminus pantophysin can be detected by immunofluorescence microscopy in both exocrine and endocrine cells of human pancreas, and in cultured cells, colocalizing with constitutive secretory and endocytotic vesicle markers in nonneuroendocrine cells and with synaptophysin in cDNA-transfected epithelial cells. By immunoelectron microscopy, the majority of pantophysin reactivity is detected at vesicles with a diameter of < 100 nm that have a smooth surface and an electron-translucent interior. Using cell fractionation in combination with immunoisolation, these vesicles are enriched in a light fraction and shown to contain the cellular vSNARE cellubrevin and the ubiquitous SCAMPs in epithelial cells and synaptophysin in neuroendocrine or cDNA-transfected nonneuroendocrine cells and neuroendocrine tissues. Pantophysin is therefore a broadly distributed marker of small cytoplasmic transport vesicles independent of their content.
Bilateral motor cortex disinhibition in complex regional pain syndrome (CRPS) type I of the hand

Background: Complex regional pain syndrome type I (CRPS I) develops as a consequence of trauma affecting the limbs, without obvious nerve lesion. Its features include pain, edema, autonomic dysfunction, movement disorder, and trophic changes. CNS involvement is suggested by the symptoms, but the pathophysiology of CRPS I is unknown. Objective: To assess excitability changes in the motor cortex in patients with CRPS I. Methods: The authors studied 25 patients with unilateral CRPS I involving the hand by means of transcranial magnetic stimulation using a paired-pulse paradigm. Motor threshold (MT) and intracortical inhibition and facilitation were determined on the affected and the clinically unaffected side. A control group of 20 healthy subjects was studied. Results: The authors found a significant reduction of intracortical inhibition on both sides of patients with CRPS compared with control subjects, whereas intracortical facilitation and MT did not differ significantly. However, in the patients’ group, the presence of allodynia significantly decreased MT. Conclusions: The authors showed a bilateral disinhibition of the motor cortex in patients with complex regional pain syndrome.
Invasive cervical resorption: treatment challenges

Invasive cervical resorption is a relatively uncommon form of external root resorption. It is characterized by invasion of cervical region of the root by fibrovascular tissue derived from the periodontal ligament. This case presents an invasive cervical resorption occurring in maxillary lateral incisor, following damage in cervical cementum from avulsion and intracoronal bleaching procedure. Flap reflection, debridement and restoration with glass ionomer cement were performed in an attempt to repair the defect. But after 2 mon, more resorption extended apically. Considering root stability and recurrence potential, we decided to extract the tooth. Invasive cervical resorption in advanced stages may present great challenges for clinicians. Therefore, prevention and early detection must be stressed when dealing with patients presenting history of potential predisposing factors.
Analysis of Vocal Tract Characteristics for Near-term Suicidal Risk Assessment

Summary Objectives: Among the many clinical decisions that psychiatrists must make, assessment of a patient’s risk of committing suicide is definitely among the most important, complex and demanding. One of the authors reviewing his clinical experience observed that successful predictions of suicidality were often based on the patient’s voice independent of content. The voices of suicidal patients exhibited unique qualities, which distinguished them from non-suicidal patients. In this study we investigated the discriminating power of lower order mel-cepstral coefficients among suicidal, major depressed, and non-suicidal patients. Methods: Our sample consisted of 10 near-term suicidal patients, 10 major depressed patients, and 10 non-depressed control subjects. Gaussian mixtures were employed to model the class distributions of the extracted features. Results and Conclusions: As a result of two-sample ML classification analyses, first four mel-cepstral coefficients yielded exceptional classification performance with correct classification scores of 80% between near-term suicidal patients and non-depressed controls, 75% between depressed patients and non-depressed controls, and 80% between near-term suicidal patients and depressed patients.
Diffusion of knowledge in social media networks: effects of reputation mechanisms and distribution of knowledge roles

Social media platforms serve as important tools for diffusing knowledge within organizations. The factors affecting knowledge diffusion through social media networks (SMNs) need to therefore be better understood. Accordingly, this paper focuses on two SMN‐specific characteristics – reputation mechanisms and the distribution of knowledge roles – which are argued to enhance and enable, respectively, the smooth transfer of knowledge in a SMN. To examine their effects, we distinguish between two types of reputation mechanisms – adaptive and objective – and across three distinct knowledge roles in SMNs: seekers, contributors and brokers. We argue that the extent of knowledge diffusion in the SMN depends on the type of mechanism and the relative distribution of these three roles. Using data collected through an agent‐based simulation, we find that (a) the distribution of knowledge roles affects knowledge diffusion, with distributions consisted of more brokers outperforming others and (b) objective reputation mechanisms outperform adaptive mechanisms. Furthermore, we find that reputation mechanisms and distribution of knowledge roles interact to influence knowledge diffusion. The study's implications for future research and practice are discussed in the light of its limitations. © 2016 John Wiley & Sons Ltd
Computationally efficient surrogate response models for mechanistic–empirical pavement analysis and design

This paper proposes the use of neural network- (NN-) based pavement structural analysis tools as surrogates for the flexible pavement response analysis in the new mechanistic empirical pavement design guide (MEPDG) developed for the American State Highway and Transportation Officials (AASHTO). Some of the recent successful applications of NN-based structural analysis models for predicting critical flexible pavement responses and nonlinear pavement layer moduli from falling weight deflectometer (FWD) deflection basins are highlighted. Because NNs excel at mapping in higher-order spaces, such models can go beyond the existing univariate relationships between pavement structural responses and performance (such as the subgrade strain criteria for considering flexible pavement rutting). The NN-based rapid prediction models could easily be incorporated into the newer versions of the MEPDG, which will continue to be updated. This can lead to better performance prediction and also reduce the risk of premature pavement failure.
Medium-Level Laser in Chronic Tinnitus Treatment

The purpose of this study was to evaluate the effect of medium-level laser therapy in chronic tinnitus treatment. In a prospective double-blind placebo-controlled trial, either active laser (450 mW, 830 nm combined Ga-Al-As diode laser) or placebo irradiation was applied through the external acoustic meatus of the affected ear towards the cochlea. Fourty-eight patients with chronic tinnitus were studied. The main outcome was measured using the Goebel tinnitus questionnaire, visual analogue scales measuring the perceived loudness of tinnitus, the annoyance associated with tinnitus, and the degree of attention paid to tinnitus as well as psycho-acoustical matches of tinnitus pitch and loudness. The results did show only very moderate temporary improvement of tinnitus. Moreover, no statistically relevant differences between laser and placebo group could be found. We conclude that medium-level laser therapy cannot be regarded as an effective treatment of chronic tinnitus in our therapy regime considering the limited number of patients included in our study.