Miracle-dz/UniFAR-FTUs huggingface dataset:
Computer-based critics

The authors describe computer-based critics and articulate some of the general principles learned from their system-building experience. They propose a general framework for critics, present specific requirements, and describe two prototypical critic systems: LISP-CRITIC, which criticizes Lisp programs, and CRACK, a system that assists the user in designing a kitchen. The authors illustrate the generalized main components of the critic systems and discuss their evaluation. It is concluded that computer-based critics incorporate many powerful ideas from human-computer communications and artificial intelligence into a system that makes use of the best aspects of human and computational cognition. They have the potential to provide a symbiotic relationship between a user and a knowledge-based system. The results should be applicable to the entire class of cooperative problem-solving systems. <<ETX>>
Risk of surgical delivery to deep nuclei: A meta‐analysis

Many novel strategies aimed at neuroprotection or neurorestoration involve surgical delivery of agents to deep nuclei along multiple trajectories. Using intracerebral hemorrhage on a per‐trajectory basis as our primary end point, we quantified the level of surgical risk associated with agent delivery to deep nuclei. Secondarily, we quantified other event rates and examined relationships between intracerebral hemorrhage and 8 variables related to patient and practice characteristics. Meta‐analytic techniques were used to pool complication rates reported in published articles involving deep brain stimulator electrode implantation or infusion of vectors, tissues, or trophic factors. One hundred nine studies were included in our analysis, comprising 6237 patients and 9890 trajectories to deep nuclei. The estimated per‐trajectory intracerebral hemorrhage rate was 1.57% (95% confidence interval, 1.26%–1.95%). The proportion of trajectories leading to permanent or serious neurological deficits was 0.41% (0.28%–0.60%). The estimated mortality rate per trajectory was 0.14% (0.07%–0.29%). No relationship between intracerebral hemorrhage and sex, age, duration of disease, or exclusion of patients with surgical complications was observed; a significant positive relationship was observed with the use of microelectrode recording and a significant negative relationship with putamenal delivery. Our results show a significant difference in intracerebral hemorrhage rates between inoculations and electrode implantation. Our findings suggest that studies involving multiple trajectories to deep nuclei involve a high level of risk. However, inoculations may be significantly safer than electrode implantation. Our analysis has implications for the ethics of preclinical research, independent review of risk, subject selection, and adverse event reporting. © 2011 Movement Disorder Society
Functional domains of Agrobacterium tumefaciens single-stranded DNA-binding protein VirE2

The transferred DNA (T-DNA) portion of the Agrobacterium tumefaciens tumor-inducing (Ti) plasmid enters infected plant cells and integrates into plant nuclear DNA. Direct repeats define the T-DNA ends; transfer begins when the VirD2 endonuclease produces a site-specific nick in the right-hand border repeat and attaches to the 5' end of the nicked strand. Subsequent events liberate the lower strand of the T-DNA from the Ti plasmid, producing single-stranded DNA molecules (T strands) that are covalently linked to VirD2 at their 5' ends. A. tumefaciens appears to transfer T-DNA into plant cells as a T-strand-VirD2 complex. The bacterium also transports VirE2, a cooperative single-stranded DNA-binding protein, into plant cells during infection. Both VirD2 and VirE2 contain nuclear localization signals that may direct these proteins, and bound T strands, into plant nuclei. Here we report the locations of functional regions of VirE2 identified by eight insertions of XhoI linker oligonucleotides, and one deletion mutation, throughout virE2. We examined the effects of these mutations on virulence, single-stranded DNA (ssDNA) binding, and accumulation of VirE2 in A. tumefaciens. Two of the mutations in the C-terminal half of VirE2 eliminated ssDNA binding, whereas two insertions in the N-terminal half altered cooperativity. Four of the mutations, distributed throughout virE2, decreased the stability of VirE2 in A. tumefaciens. In addition, we isolated a mutation in the central region of VirE2 that decreased tumorigenicity but did not affect ssDNA binding or VirE2 accumulation. This mutation may affect export of VirE2 into plant cells or nuclear localization of VirE2, or it may affect an uncharacterized activity of VirE2.
Over-Reporting in Handwashing Self-Reports: Potential Explanatory Factors and Alternative Measurements

Handwashing interventions are a priority in development and emergency aid programs. Evaluation of these interventions is essential to assess the effectiveness of programs; however, measuring handwashing is quite difficult. Although observations are considered valid, they are time-consuming and cost-ineffective; self-reports are highly efficient but considered invalid because desirable behaviour tends to be over-reported. Socially desirable responding has been claimed to be the main cause of inflated self-reports, but its underlying factors and mechanisms are understudied. The present study investigated socially desirable responding and additional potential explanatory factors for over-reported handwashing to identify indications for measures which mitigate over-reporting. Additionally, a script-based covert recall, an alternative interview question intended to mitigate recall errors and socially desirable responding, was developed and tested. Cross-sectional data collection was conducted in the Borena Zone, Ethiopia, through 2.5-hour observations and 1-hour interviews with the primary caregivers in households. A total sample of N = 554 was surveyed. Data were analysed with correlation and multiple regression analyses and dependent t-tests. Over-reporting of handwashing was associated with factors assumed to be involved in (1) socially desirable responding, (2) encoding and recall of information, and (3) dissonance processes. The latter two factor groups explained over-reported handwashing beyond socially desirable responding. The alternative interview question—script-based covert recall—reduced over-reporting compared to conventional self-reports. Although the difficulties involved in measuring handwashing by self-reports and observations are widely known, the present study is the first to investigate the factors which explain over-reporting of handwashing. This research contributes to the limited evidence base on a highly important subject: how to evaluate handwashing interventions efficiently and accurately.
Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients

Purpose: FoxP3+ Tregs inhibit immune responses against tumors. KW-0761 is a humanized anti-human CCR4 monoclonal antibody (mAb) that has antibody-dependent cellular cytotoxicity activity. Depletion of CCR4-expressing FoxP3+ CD4 Tregs by KW-0761 infusion was investigated in solid cancer patients. Experimental Design: We conducted a phase Ia clinical trial of KW-0761 infusion in 7 lung and 3 esophageal cancer patients. Toxicity, clinical efficacy, changes in lymphocyte subpopulations, including Tregs, and induction of immune responses were analyzed. Results: The results showed that KW-0761 infusion in a dose range between 0.1 mg/kg and 1.0 mg/kg was safe and well tolerated. No dose-limiting toxicity was observed. Four of 10 patients showed stable disease during treatment and were long survivors. The monitoring of FoxP3+ Tregs in the peripheral blood mononuclear cells during treatment indicated efficient depletion of those cells, even at the lowest dose of 0.1 mg/kg used. The reduction in Th 1 CD4 T cells and CD8 T cells was limited, whereas a significant reduction was observed with Th 2 and Th 17 CD4 T cells. Immune responses to cancer/testis (CT) antigens and an autoantibody response to thyroid peroxidase were observed in some patients. Conclusions: The findings showed Tregs depletion and the possible occurrence of an immune response following KW-0761 infusion. Combined use of KW-0761 to deplete FoxP3+ Tregs with other immunotherapies, such as cancer vaccines or checkpoint inhibitors, is a promising approach to augment immune responses. Clin Cancer Res; 21(19); 4327–36. ©2015 AACR.
Nielsen: Involving Patients with E-health – The Dialogic Dynamics of Information Filtration Work

With e-health technologies, patients are invited as co-producers of data and information. The invitation sparks new expectations, yet often results in disappointments. With persistent ambitions to involve patients by means of e-health, it seems crucial to gain a better understanding of the nature, sources and workings of the expectations that come with being invited. I analyse the use of an e-health system for ICD-patients, focusing on how patients sought to serve as information providers. Continuing STS-research on invisible work in technology use, I show how using the system involved complex work of filtering information. I argue that this ‘filtration work’ was inherently dialogic, that is, characterized by receiver-orientation and the anticipation of response and guided by different communicative projects. For the patients, filtration work thus, first of all, required certain skills and knowledge about the infrastructure of care. Secondly, it entailed the expectation that the system? " for better or for worse? "would facilitate not just information sharing but open up a dialogue, which glaringly contrasted with the clinicians’ expectations of being able to better manage dialogue. I suggest that understanding the dialogic dynamics and ‘overflows’ of information filtration work can help unpack the challenges of facilitating (patient) participation with e-health and other filtration devices.
Conductive-AFM tomography for 3D filament observation in resistive switching devices

In this paper we demonstrate a novel characterization technique for the observation of the conductive filament in conductive bridging memory devices (CBRAM). The conductive filament is observed for a scaled memory element programmed under 10μA operative current. After the electrical programing, the C-AFM tomography enables the 3D analysis of the conductive filament within the switching layer.
Predictive wind turbine simulation with an adaptive lattice Boltzmann method for moving boundaries

Operating horizontal axis wind turbines create large-scale turbulent wake structures that affect the power output of downwind turbines considerably. The computational prediction of this phenomenon is challenging as efficient low dissipation schemes are necessary that represent the vorticity production by the moving structures accurately and that are able to transport wakes without significant artificial decay over distances of several rotor diameters. We have developed a parallel adaptive lattice Boltzmann method for large eddy simulation of turbulent weakly compressible flows with embedded moving structures that considers these requirements rather naturally and enables first principle simulations of wake-turbine interaction phenomena at reasonable computational costs. The paper describes the employed computational techniques and presents validation simulations for the Mexnext benchmark experiments as well as simulations of the wake propagation in the Scaled Wind Farm Technology (SWIFT) array consisting of three Vestas V27 turbines in triangular arrangement.
Analyst Hype in Ipos: Explaining the Popularity of Bookbuilding

The bookbuilding IPO procedure has captured significant market share from auction alternatives recently, despite the significantly lower costs related to the auction mechanism. In France, where both mechanisms were used in the 1990s, the ostensible advantages of bookbuilding were advertising-related benefits. Book-built issues were more likely to be followed and positively recommended by lead underwriters. Even nonunderwriters' analysts promote book-built issues more in order to curry favor with the IPO underwriter for allocations of future deals. Yet we do not observe valuation or post-IPO return differentials that suggest these types of promotion have any value to the issuing firm.
Maximizing the Sum-Rate of Amplify-and-Forward Two-Way Relaying Networks

This letter addresses the problem of beamforming design for an amplify-and-forward (AF) based two-way relaying network (TWRN) which consists of two terminal nodes and several relay nodes. Considering a two-time-slot relaying scheme, we design the optimal beamforming coefficients to maximize the sum-rate of AF-based TWRN under total relay power constraint (TRPC). Although the optimization problem is neither convex nor concave, we show that the global optimal solution can be obtained by the branch-and-bound algorithm. To address the computational complexity concern, we also propose a low-complexity suboptimal solution which is obtained by optimizing a cost function over one real variable only. Simulation results show that the proposed optimal solution outperforms existing schemes significantly. Moreover, we show that the suboptimal solution only suffers small sum-rate losses compared to the optimal solution.
Effects of emotion and perspective on remembering events: An eye-tracking study

The main objective of this study is to investigate the effects of the emotional content of an event and participants’ perspective on the memory and eye-tracking measurements for central and peripheral de-tails. The data have been collected from 130 undergraduate male students (18- 33 ages). Three series of seven different emotional thematic photographs (positive, negative, neutral) were used. Participants were subjected to only one of the three series, either in his own perspective condition or observer perspective condition. During the presentation of thematic photograph series participants’ eye movements were re-corded. All analysis for memory and eye-tracking measurements were carried out with 3 (Emotional Content: Positive, Negative, Neutral) X 2 (Participants’ perspective: Own perspective, observer perspec-tive) between-subjects factorial ANOVA. The results indicated that although central and peripheral de-tails took almost equal attention in both negative and neutral events, only details of the negative event was remembered better. In addition, when compared to negative and neutral events participants looked longer at positive event’s central details as well as peripheral details, only details of negative event were remembered better. Consequently, memory enhancement effect occured only in negative emotional event both for central and peripheral details, even though participants paid less or equal attention these details. In addition to effects of emotion, it was seen that like autobiographical memory (Nigro and Neisser, 1983) participants’ perspective has also an effect on event memory and attention measured by eye-tracking. According to eye-tracking results looking with his own perspective to the event causes narrowing of attention while looking with observer’s perspective to event causes extending of attention. In memory results it was seen that participants in his own perspective condition remembered central details better than participants in the observer condition. In conclusion, it is observed that enhanced memory for neg-ative emotional event can occur independently of attention, so it could be said that attention is not suffi-cient by itself to remember an event with details, emotional dimension of the event has a decisive role. Additionally, perspective have an effect on attention as well as event memory.
Phylogeny of mycoplasmalike organisms (phytoplasmas): a basis for their classification

A global phylogenetic analysis using parsimony of 16S rRNA gene sequences from 46 mollicutes, 19 mycoplasmalike organisms (MLOs) (new trivial name, phytoplasmas), and several related bacteria placed the MLOs definitively among the members of the class Mollicutes and revealed that MLOs form a large discrete monophyletic clade, paraphyletic to the Acholeplasma species, within the Anaeroplasma clade. Within the MLO clade resolved in the global mollicutes phylogeny and a comprehensive MLO phylogeny derived by parsimony analyses of 16S rRNA gene sequences from 30 diverse MLOs representative of nearly all known distinct MLO groups, five major phylogenetic groups with a total of 11 distinct subclades (monophyletic groups or taxa) could be recognized. These MLO subclades (roman numerals) and designated type strains were as follows: i, Maryland aster yellows AY1; ii, apple proliferation AP-A; iii, peanut witches'-broom PnWB; iv, Canada peach X CX; v, rice yellow dwarf RYD; vi, pigeon pea witches'-broom PPWB; vii, palm lethal yellowing LY; viii, ash yellows AshY; ix, clover proliferation CP; x, elm yellows EY; and xi, loofah witches'-broom LfWB. The designations of subclades and their phylogenetic positions within the MLO clade were supported by a congruent phylogeny derived by parsimony analyses of ribosomal protein L22 gene sequences from most representative MLOs. On the basis of the phylogenies inferred in the present study, we propose that MLOs should be represented taxonomically at the minimal level of genus and that each phylogenetically distinct MLO subclade identified should represent at least a distinct species under this new genus.
On the Nonexistence of Perfect Codes in the Johnson Scheme

Although it was conjectured by Delsarte in 1973 that no nontrivial perfect codes exist in the Johnson scheme, only very partial results are known. In this paper we considerably reduce the range in which perfect codes in the Johnson scheme can exist; e.g., we show that there are no nontrivial perfect codes in the Johnson graph $J(2w+p,w)$, $p$ prime. We give theorems about the structure of perfect codes if they exist. This involved structure gives more evidence in support of the belief that no nontrivial perfect codes exist in the Johnson scheme.
Episodic memory—From brain to mind

Neuronal mechanisms of episodic memory, the conscious recollection of autobiographical events, are largely unknown because electrophysiological studies in humans are conducted only in exceptional circumstances. Unit recording studies in animals are thus crucial for understanding the neurophysiological substrate that enables people to remember their individual past. Two features of episodic memory—autonoetic consciousness, the self‐aware ability to “travel through time”, and one‐trial learning, the acquisition of information in one occurrence of the event—raise important questions about the validity of animal models and the ability of unit recording studies to capture essential aspects of memory for episodes. We argue that autonoetic experience is a feature of human consciousness rather than an obligatory aspect of memory for episodes, and that episodic memory is reconstructive and thus its key features can be modeled in animal behavioral tasks that do not involve either autonoetic consciousness or one‐trial learning. We propose that the most powerful strategy for investigating neurophysiological mechanisms of episodic memory entails recording unit activity in brain areas homologous to those required for episodic memory in humans (e.g., hippocampus and prefrontal cortex) as animals perform tasks with explicitly defined episodic‐like aspects. Within this framework, empirical data suggest that the basic structure of episodic memory is a temporally extended representation that distinguishes the beginning from the end of an event. Future research is needed to fully understand how neural encodings of context, sequences of items/events, and goals are integrated within mnemonic representations of autobiographical events. © 2006 Wiley‐Liss, Inc.
Cluster Coding Algorithm for Stochastic Textures Identification

A stochastic texture is a texture whereby the arrangement of the pattern is random in nature. The identification for each of these textures is uncertain and usually involves complex methods to search for the locations of the correlation between these textures. We propose the cluster coding algorithm which could easily classify the stochastic textures in a semantic way based on statistical features. This algorithm is successfully applied in both synthetic and real-life textures for segmentation. In this study, the cluster coding showed a significant improvement over other techniques in terms of classification accuracy and computation time.
Bullying on the pixel playground: Investigating risk factors of cyberbullying at the intersection of children’s online-offline social lives

Although cyberbullying as a serious social problem has received significant attention within the mass media as well as among researchers, experiences of cyberbullying among children in the U.S. are still occurring (Dean, 2012; Salazar, 2010). The purpose of this study was to examine the relationship between social factors (i.e., sociability, social networking site use, Internet use via cell phones), risky online behaviors (i.e., lying about age, sexting, and harassing others), children’s emotional attachment to interactions within SNS, and parental involvement in children’s online social lives on the likelihood of being victims of cyberbullying as well as offline bullying. We found that increased sociability and parental involvement decreased the likelihood of being both cyberbullied and being bullied offline; daily SNS use, Internet use via cell phones, emotional attachment to interactions within SNS, and engaging in risky online behaviors increased the likelihood of being both cyberbullied and bullied offline. The findings suggest (1) cyberbullying is not categorically distinct from offline bullying; (2) future research is necessary to explore the qualitative impact of various risky online behaviors on both online and offline bullying; and (3) research is necessary to further understand the qualitative dimensions of parental involvement and emotional investment in online social life in decreasing online and offline bullying.
Diabetic hepatitis preceding the onset of glucose intolerance

A patient who abstained from alcohol consumption but who had asymptomatic chronic progressive hepatomegaly, mild disturbance of liver function tests and hepatitis resembling alcoholic hepatitis (nonalcoholic steatohepatitis) developed glucose intolerance several years after the hepatitis was diagnosed. The patient had a family history of both diabetes and chronic liver disease. A lesion resembling alcoholic hepatitis in a patient who denies alcohol consumption, may be diabetic or pre‐diabetic in aetiology and such a patient should be followed up with glucose tolerance tests.
The self-serving function of hypochondriacal complaints: physical symptoms as self-handicapping strategies.

The present experiment tested the hypothesis that hypochondriacal individuals commonly use reports of physical illness and symptoms as a strategy to control attributions made about their performances in evaluative settings (i.e., self-handicapping strategies). Specifically, it was predicted that hypochondriacal individuals would report more recent physical illness and complaints and more current physical symptoms in an evaluative setting in which poor health could serve as an alternative explanation for poor performance than would either individuals in an evaluative setting in which poor health was precluded as an excuse or individuals in a nonevaluative setting. As predicted, results supported this self-protective pattern of complaints in a hypochondriacal sample but not in a nonhypochondriacal group. The self-protective role of hypochondriacal behavior is discussed in relation to other theory and research on the nature and treatment of hypochondriasis.