Miracle-dz/UniFAR-FTUs huggingface dataset:
Practice-based versus telemedicine-based collaborative care for depression in rural federally qualified health centers: a pragmatic randomized comparative effectiveness trial.

OBJECTIVE Practice-based collaborative care is a complex evidence-based practice that is difficult to implement in smaller primary care practices that lack on-site mental health staff. Telemedicine-based collaborative care virtually co-locates and integrates mental health providers into primary care settings. The objective of this multisite randomized pragmatic comparative effectiveness trial was to compare the outcomes of patients assigned to practice-based and telemedicine-based collaborative care. METHOD From 2007 to 2009, patients at federally qualified health centers serving medically underserved populations were screened for depression, and 364 patients who screened positive were enrolled and followed for 18 months. Those assigned to practice-based collaborative care received evidence-based care from an on-site primary care provider and a nurse care manager. Those assigned to telemedicine-based collaborative care received evidence-based care from an on-site primary care provider and an off-site team: a nurse care manager and a pharmacist by telephone, and a psychologist and a psychiatrist via videoconferencing. The primary clinical outcome measures were treatment response, remission, and change in depression severity. RESULTS Significant group main effects were observed for both response (odds ratio=7.74, 95% CI=3.94-15.20) and remission (odds ratio=12.69, 95% CI=4.81-33.46), and a significant overall group-by-time interaction effect was observed for depression severity on the Hopkins Symptom Checklist, with greater reductions in severity over time for patients in the telemedicine-based group. Improvements in outcomes appeared to be attributable to higher fidelity to the collaborative care evidence base in the telemedicine-based group. CONCLUSIONS Contracting with an off-site telemedicine-based collaborative care team can yield better outcomes than implementing practice-based collaborative care with locally available staff.
Rock Typing: Keys to Understanding Productivity in Tight Gas Sands

This paper presents a work-flow process to describe and characterize tight gas sands. The ultimate objective of this work-flow is to provide a consistent methodology to systematically integrate both large-scale geologic elements and small-scale rock petrology with the physical rock properties for low-permeability sandstone reservoirs. To that end, our work-flow integrates multiple data evaluation techniques and multiple data scales using a core-based rock typing approach that is designed to capture rock properties characteristic of tight gas sands. Fundamental to this process model are identification and comparison of three different rock types — depositional, petrographic, and hydraulic. These rock types are defined as: ● Depositional — These are rock types that are derived from core-based descriptions of genetic units which are defined as collections of rocks grouped according to similarities in composition, texture, sedimentary structure, and stratigraphic sequence as influenced by the depositional environment. These rock types represent original large-scale rock properties present at deposition. ● Petrographic — These are rock types which are also described within the context of the geological framework, but the rock type criteria are based on pore-scale, microscopic imaging of the current pore structure — as well as the rock texture and composition, clay mineralogy, and diagenesis. ● Hydraulic — These are rock types that are also defined at the pore scale, but in this case we define "hydraulic" rock types as those that quantify the physical flow and storage properties of the rock relative to the native fluid(s) — as controlled by the dimensions, geometry, and distribution of the current pore and pore throat structure. Each rock type represents different physical and chemical processes affecting rock properties during the depositional and paragenetic cycles. Since most tight gas sands have been subjected to post-depositional diagenesis, a comparison of all three rock types will allow us to assess the impact of diagenesis on rock properties. If diagenesis is minor, the depositional environment (and depositional rock types) as well as the expected rock properties derived from those depositional conditions will be good predictors of rock quality. However, if the reservoir rock has been subjected to significant diagenesis, the original rock properties present at deposition will be quite different than the current properties. More specifically, use of the depositional environment and the associated rock types (in isolation) to guide field development activities may result in ineffective exploitation.
Absorption Spectra and Electron-Vibration Coupling of Ti:Sapphire From First Principles

First-principles calculations are performed to study the absorption spectra and electronvibration coupling of titanium-doped sapphire (Ti:Al2O3). Geometry optimization shows a local structure relaxation after the doping of Ti. Electronic band structure calculation shows that five additional dopant energy bands are observed around the band gap of Al2O3, and are attributed to the five localized d orbitals of the Ti dopant. The optical absorption spectra are then predicted by averaging the oscillator strength during a 4 ps first-principles molecular dynamics (MD) trajectory, and the spectra agree well with the experimental results. Electron-vibration coupling is further investigated by studying the response of the ground and excited states to the Eg vibrational mode, for which a configuration coordinate diagram is obtained. Stokes shift effect is observed, which confirms the red shift of emission spectra of Ti:sapphire. This work offers a quantitative understanding of the optical properties and crystal-field theory of Ti-doped sapphire. The firstprinciples calculation framework developed here can also be followed to predict the optical properties and study the electron-vibration coupling in other doped materials. [DOI: 10.1115/1.4032177]
Economic Report of the President

Abstract : I am pleased to report that the American economy today is strong. We are enjoying the longest economic expansion ever recorded, with more than 22 million new jobs since 1993, the lowest unemployment rate in 30 years, the lowest female unemployment rate in 40 years, the lowest Hispanic and African-American unemployment rates ever recorded, and the highest home ownership rate on record. This economic expansion has been not only unusually long, but also broad and deep. For the first time in decades, wages are rising at all income levels. We have the lowest child poverty in 20 years and the lowest poverty rate for single mothers ever recorded. Since 1993 the median family income has gone up more than $6,000, and for African-American families it has risen even more. The number of families who own stock has grown by 40 percent. Our current economic strength is the result not of chance, but of a choice the American people made 8 years ago. At that time, 10 million of our fellow citizens were out of work. Interest rates were high. The Federal budget deficit was $290 billion and rising. And the Federal debt had quadrupled in the previous 12 years, imposing a crushing burden on our economy and on our children.
Better Safe Than Sorry? The Safety Margin Surrounding the Body Is Increased by Anxiety

The defensive peripersonal space represents a “safety margin” advantageous for survival. Its spatial extension and the possible relationship with personality traits have never been investigated. Here, in a population of 15 healthy human participants, we show that the defensive peripersonal space has a sharp boundary, located between 20 and 40 cm from the face, and that within such space there is a thin, “highest-risk area” closest to the face (i.e., an “ultra-near” defensive space). Single-subject analysis revealed clear interindividual differences in the extension of such peripersonal space. These differences are positively related to individual variability in trait anxiety. These findings point to the potential for measuring a range of defensive behaviors in relation to individual levels of anxiety. Such measures will allow developing procedures to test risk assessment abilities, particularly in professions that require reacting quickly to aversive stimuli near the body, such as firemen, policemen, and military officers. This may also lead to possible interventions to improve their performance under pressure.
Managing capital flows and exchange rates, perspectives from the Pacific Basin. Essays originally prepared for a conference sponsored by the Center for Pacific Basin Monetary and Economic Studies at the Federal Reserve Bank of San Francisco, held Sept. 26-27, 1996

1. Managing capital flows and exchange rates: overview Reuven Glick Part I. Determinants of Capital Flows and Exchange Rates: 2. US portfolio investment in Asian capital markets Henning Bohn and Linda L. Tesar 3. FDI, trade, and real exchange rate linkages in developing countries Linda S. Goldberg and Michael Klein 4. Capital inflows and the real exchange rate: analytical framework and econometric evidence Pierre-Richard Agenor and Alexander Hoffmaister 5. Risk and financial development: a comparative case study of Mexico and Indonesia Theo S. Eicher and Stephen J. Turnovsky Part II. Exchange Rate Crisis and Contagion: 6. Exchange rate instability: determinants and predictability Richard A. Meese and Andrew K. Rose 7. Derivative products in exchange rate crisis Peter Garber and Subir Lall 8. Crisis, contagion, and country funds: effects on East Asia and Latin America Jeffrey A. Frankel and Sergio L. Schmukler 9. Co-movements among emerging equity markets Holger Wolf Part III. Effects of Capital Inflows: 10. Net capital inflows: how much to accept, how much to resist? Helmut Reisen 11. The overborrowing syndrome: are East Asian economies different? Ronald I. McKinnon and Huw Pill 12. Capital inflows, financial intermediation, and aggregate demand: empirical evidence from Mexico and other Pacific Basin countries Steven Kamin and Paul Wood Part IV. Policy Responses to Capital Inflows: 13. Speculative capital inflows and exchange rates targeting in the Pacific Basin: theory and evidence Kenneth Kletzer and Mark Spiegel 14. Too much of a good thing: the macroeconomic effects of taxing capital inflows Carmen M. Reinhart and R. Todd Smith 15. Exchange rate policies and capital account management: Chile in the 1990s Kevin Cowen and Jose De Gregorio.
A smart actuator-based underwater microrobot with two motion attitudes

Various microrobots were widely used in the fields of biomedical engineering and underwater operation during the last few years. By having a compact structure, low driving voltage and a simple control system, microrobots could complete a variety of underwater tasks, even in limited spaces. To realize the multifunctionality of the microrobot for adapting to complex underwater environments, we proposed a walking biomimetic microrobot with two kinds of motion attitudes, lying state and standing state. The microrobot used eleven ICPF (ionic conducting polymer film) actuators to move and two SMA (shape memory alloy) actuators to change motion attitude. In the lying state, the microrobot could implement stick insect-inspired walking/rotating motion, fish-like swimming motion, horizontal grasping motion, and floating motion. In the standing state, it could implement inchworm-inspired crawling motion along two directions and vertical grasping motion. Then we developed a prototype of multi-functional biomimetic microrobot and evaluated its walking, rotating and floating speeds experimentally. Experimental results indicated that the robot could obtain a maximal walking speed of 3.6mm/s, a maximal rotating speed of 9deg/s and a maximal floating speed of 7.14mm/s.
Convolutional Neural Network-based Place Recognition

Recently Convolutional Neural Networks (CNNs) have been shown to achieve state-of-the-art performance on various classification tasks. In this paper, we present for the first time a place recognition technique based on CNN models, by combining the powerful features learnt by CNNs with a spatial and sequential filter. Applying the system to a 70 km benchmark place recognition dataset we achieve a 75% increase in recall at 100% precision, significantly outperforming all previous state of the art techniques. We also conduct a comprehensive performance comparison of the utility of features from all 21 layers for place recognition, both for the benchmark dataset and for a second dataset with more significant viewpoint changes.
Central Bank Credibility, Reputation and Inflation Targeting in Historical Perspective

This paper examines the historical evolution of central bank credibility using both historical narrative and empirics for a group of 16 countries, both advanced and emerging. It shows how the evolution of credibility has gone through a pendulum where credibility was high under the classical gold standard before 1914 before being lost and not fully regained until the 1980s. This characterization does not, however, seem to apply to the monetary history in the emerging markets examined in the paper. Nevertheless, credibility in all the economies examined has been enhanced in recent decades thanks to the adoption of inflation targeting. However, the recent financial crisis and the call for central banks to focus more on financial stability relying on macro prudential regulation may pose significant challenges for central bank credibility.
Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells

Neural stem cells (NSCs) are self-renewing cells that can differentiate into multiple neural lineages and repopulate regions of the brain after injury. We have investigated the role of endocannabinoids (eCBs), endogenous cues that modulate neuronal functions including neurogenesis, and their receptors CB1 and CB2 in mouse NSCs. Real-time PCR and Western blot analyses indicated that CB1 is present at higher levels than CB2 in NSCs. The eCB anandamide (AEA) or the CB1-specific agonist ACEA enhanced NSC differentiation into neurons, but not astrocytes and oligodendrocytes, whereas the CB2-specific agonist JWH133 was ineffective. Conversely, the effect of AEA was inhibited by CB1, but not CB2, antagonist, corroborating the specificity of the response. CB1 activation also enhanced maturation of neurons, as indicated by morphometric analysis of neurites. CB1 stimulation caused long-term inhibition of the ERK1/2 pathway. Consistently, pharmacological inhibition of the ERK1/2 pathway recapitulated the effects exerted by CB1 activation on neuronal differentiation and maturation. Lastly, gene array profiling showed that CB1 activation augmented the expression of genes involved in neuronal differentiation while decreasing that of stemness genes. These results highlight the role of CB1 in the regulation of NSC fate and suggest that its activation may represent a pro-neuronal differentiation signal.
Combination of search techniques for improved spotting of OOV keywords

The most common pipelines in keyword spotting involve some kind of speech recognition, which leads to the generation of sets of plausible hypotheses (e.g., word lattices), which are subsequently explored. The case of out-of-vocabulary (OOV) keywords is of special interest, because it requires representing keywords and/or lattices in an alternative format, so that the two can match. A number of techniques for dealing with OOV keywords have appeared in the literature; here, we focus on (i) fuzzy-phonetic search using phonetic confusion networks [1], and (ii) proxy-keyword search [2]. As we demonstrate in this paper, the combination of these two diverse techniques improves the ATWV of OOV keywords by at least 3% on average over the five development languages used in the second year of the IARPA Babel program.
Summary Statement

PURPOSE: With the aging infrastructure, PATCO is requesting approval of sole source justification for replacement parts from original equipment manufacturers (OEMs). Staff has recognized an opportunity to improve procurement efficiencies, streamline work processes and reduce approval redundancies through an annual sole source justification of components and parts critical to PATCO’s operation. The items to be procured are indexed in the Exhibit A attachment. Based on a thorough review of these items, PATCO procurement has determined that there is only one provider for these particular parts and that they have negotiated the best possible pricing for these items. This approach is consistent with the Lean Government initiatives and philosophies to improve the effectiveness and efficiency of PATCO procurement functions and increase transparency.
Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES

Aims. The aim of our study was to determine the physiologic impact of NOTES and to compare the transgastric and transcolonic approaches. Methods. Thirty pigs were randomized to transgastric, transcolonic, or laparoscopic peritoneoscopy. Blood was drawn and analyzed for C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin- (IL-) 1β, IL-6, WBCs, and platelets. Results. Endoscopic closure with an OTSC was successful in all 20 animals. The postoperative course was uneventful in all animals. CRP values rose on day 1 in all animals and slowly declined to baseline levels on day 14 with no differences between the groups (P > 0.05, NS). The levels of TNF-α were significantly increased in the transcolonic group (P < 0.01); however this difference was already present prior to the procedure and remained unchanged. No differences were observed in IL1-β and IL-6 values. There was a temporary rise of WBC on day 1 and of platelets on day 7 in all groups (P > 0.05, NS). Conclusions. Transgastric, transcolonic, and laparoscopic peritoneoscopy resulted in similar changes in systemic inflammatory markers. Our findings do not support the assumption that NOTES is less invasive than laparoscopy.
Immune Imbalance in Nasal Polyps of Caucasian Chronic Rhinosinusitis Patients Is Associated with a Downregulation of E-Selectin

Chronic rhinosinusitis with nasal polyps (CRSwNP) in Caucasians is a chronic Th2 inflammatory disease of the nasal and paranasal mucosa and the recruitment of leukocytes to the site of inflammation is poorly understood. We studied mRNA and protein expression profiles of adhesion molecules in nasal polyp and associated inferior turbinate tissues using molecular, biochemical, and immunohistological methods. Analysis showed a strongly decreased E-selectin expression in nasal polyps with a significant difference between eosinophil and neutrophil counts in nasal polyps and balanced counts in inferior turbinates. E-selectin expression is known to be downregulated in a Th2 milieu and has an essential role in immunosurveillance by locally activating neutrophil arrest and migratory function. A downregulation of E-selectin may come along with an immune imbalance in Caucasian nasal polyps due to a significant inhibition of neutrophil recruitment. Therefore, we suggest that an upregulation of E-selectin and the associated influx of neutrophils may play a significant role in the resolution of inflammation as well as for the pathophysiology of nasal polyps of Caucasian chronic rhinosinusitis patients.
X-ray flares from the ultra-luminous X-ray source in NGC 5408

We have studied an ultra-luminous X-ray source (ULX) in the dwarf galaxy NGC 5408 with a series of XMM-Newton observations, between 2001 July and 2003 January. We find that its X-ray spectrum is best fitted with a power law of photon index Γ ≈ 2.6−2.9 and a thermal component with blackbody temperature kTbb ≈ 0.12−0.14 keV. These spectral features, and the inferred luminosity ≈ 10 40 erg s −1 in the 0.3−12 keV band, are typical of bright ULXs in nearby dwarf galaxies. The blackbody plus power-law model is a significantly better fit than either a simple power law or a broken power law (although the latter model is also acceptable at some epochs). Doppler-boosted emission from a relativistic jet is not required, although we cannot rule out this scenario. Our preliminary timing analysis shows flaring behaviour which we interpret as variability in the power- law component, on timescales of ∼10 2 s. The hard component is suppressed during the dips, while the soft thermal component is consistent with being constant. The power density spectrum is flat at low frequencies, has a break at νb ≈ 2.5 mHz, and has a slope ≈− 1 at higher frequencies. A comparison with the power spectra of Cyg X-1 and of a sample of other BH candidates and AGN suggests a mass of ∼10 2 M� . It is also possible that the BH is at the upper end of the stellar-mass class (M ∼ 50 M� ), in a phase of moderately super-Eddington accretion. The formation of such a massive BH via normal stellar evolution may have been favoured by the very metal-poor environment of NGC 5408.
Effectiveness of antibiotics given before admission in reducing mortality from meningococcal disease: systematic review

Abstract Objective To review the evidence for effectiveness of treatment with antibiotics before admission in reducing case fatality from meningococcal disease. Design Systematic review. Data sources Cochrane register of trials and systematic reviews, database of abstracts of reviews of effectiveness, health technology assessment, and national research register in England and Wales, Medline, Embase, and CAB Health. Included studies Studies describing vital outcome of at least 10 cases of meningococcal disease classified by whether or not antibiotics were given before admission to hospital. Results 14 observational studies met the review criteria. Oral antibiotic treatment given before admission was associated with reduced mortality among cases (combined risk ratio 0.17, 95% confidence interval 0.07 to 0.44). In seven studies in which all included patients were seen in primary care, the association between parenteral antibiotics before admission and outcome was inconsistent (χ2 for heterogeneity 11.02, P = 0.09). After adjustment for the proportion given parenteral antibiotics before admission, there was no residual heterogeneity. A higher proportion of patients given parenteral antibiotics before admission was associated with reduced mortality after such treatment and vice versa (P = 0.04). Conclusion Confounding by severity is the most likely explanation both for the beneficial effect of oral antibiotics and the harmful effect observed in some studies of parenteral antibiotics. We cannot conclude whether or not antibiotics given before admission have an effect on case fatality. The data are consistent with benefit when a substantial proportion of cases are treated.
Information Disclosure Profiles for Segmentation and Recommendation

People’s information disclosure does not just vary in degree, but also in kind. In fact, our recent work has identified distinct information disclosure profiles in three different datasets. In this paper I briefly iterate the findings of this work, and discuss how these profiles can be used for segmentation and recommendation purposes. I argue that segmentation is an important means to go beyond the “one-size-fits-all” approach of privacy nudges (a privacy aid that is becoming increasingly popular) towards usertailored privacy decision support.