Miracle-dz/UniFAR-FTUs huggingface dataset:
Is Mandatory Prospective Trial Registration Working to Prevent Publication of Unregistered Trials and Selective Outcome Reporting? An Observational Study of Five Psychiatry Journals That Mandate Prospective Clinical Trial Registration

Objective To address the bias occurring in the medical literature associated with selective outcome reporting, in 2005, the International Committee of Medical Journal Editors (ICMJE) introduced mandatory trial registration guidelines and member journals required prospective registration of trials prior to patient enrolment as a condition of publication. No research has examined whether these guidelines are impacting psychiatry publications. Our objectives were to determine the extent to which articles published in psychiatry journals adhering to ICMJE guidelines were correctly prospectively registered, whether there was evidence of selective outcome reporting and changes to participant numbers, and whether there was a relationship between registration status and source of funding. Materials and Methods Any clinical trial (as defined by ICMJE) published between 1 January 2009 and 31 July 2013 in the top five psychiatry journals adhering to ICMJE guidelines (The American Journal of Psychiatry, Archives of General Psychiatry/JAMA Psychiatry, Biological Psychiatry, Journal of the American Academy of Child and Adolescent Psychiatry, and The Journal of Clinical Psychiatry) and conducted after July 2005 (or 2007 for two journals) was included. For each identified trial, where possible we extracted trial registration information, changes to POMs between publication and registry to assess selective outcome reporting, changes to participant numbers, and funding type. Results Out of 3305 articles, 181 studies were identified as clinical trials requiring registration: 21 (11.6%) were deemed unregistered, 61 (33.7%) were retrospectively registered, 37 (20.4%) had unclear POMs either in the article or the registry and 2 (1.1%) were registered in an inaccessible trial registry. Only 60 (33.1%) studies were prospectively registered with clearly defined POMs; 17 of these 60 (28.3%) showed evidence of selective outcome reporting and 16 (26.7%) demonstrated a change in participant numbers of 20% or more; only 26 (14.4%) of the 181 the trials were prospectively registered and did not alter their POMs or the time frames at which they were measured. Prospective registration with no changes in POMs occurred more frequently with pharmaceutical funding. Discussion Although standards are in place to improve prospective registration and transparency in clinical trials, less than 15% of psychiatry trials were prospectively registered with no changes in POMs. Most trials were either not prospectively registered, changed POMs or the timeframes at some point after registration or changed participant numbers. Authors, journal editors and reviewers need to further efforts to highlight the value of prospective trial registration.
Aberrant expression of membrane cofactor protein and decay-accelerating factor in the endothelium of patients with systemic sclerosis. A possible mechanism of vascular damage.

BACKGROUND One of the main features of systemic sclerosis (SSc) is vascular damage, the mechanism of which is not understood. The aim of this study was to investigate if complement (C) regulatory molecules, membrane cofactor protein (MCP), decay-accelerating factor (DAF), and CD59, which normally protect endothelial cells from damage by autologous C, are absent or down-regulated in vascular endothelium of patients with SSc. A deficiency or persistent down-regulation of the above molecules is likely to render vascular endothelium of these patients susceptible to damage by physiologically or pathologically activated C. From this point of view, expression of MCP, DAF, and CD59 was tested on endothelium of skin of normal subjects and patients with diffuse and limited forms of SSc. EXPERIMENTAL DESIGN Punch biopsies of normal skin (N = 11) and lesional and non-lesional skin of patients with diffuse (N = 5) and limited (N = 5) forms of SSc were obtained and serial sections prepared. Immunoperoxidase staining of these sections was carried out using four monoclonal antibodies (MoAbs) directed to different epitopes of DAF, four to different epitopes of MCP, one to CD59 and one to von Willebrand factor. von Willebrand factor served as a marker of endothelial cells. Besides normal skin, lesional skin of systemic lupus erythematosus and several inflammatory and proliferative diseases, described below, served as controls. RESULTS The endothelium of normal skin strongly expressed all the three proteins. However, the endothelium of lesional and nonlesional skin of all the 10 patients with diffuse or limited forms of the disease tested, expressed either decreased or undetectable amounts of MCP and DAF. CD59 expression was normal in some patients and lower than normal in others. Aberrant expression of MCP, DAF, or CD59 was not found in other control inflammatory, connective tissue and proliferative diseases studied. CONCLUSIONS In view of the common function of MCP and DAF to protect self cells from autologous C, their decrease or virtual absence from the endothelium of patients with SSc strongly suggests that this deficiency may contribute to vascular damage, resulting in intima proliferation and, finally, fibrosis.
La adopción de estándares en el sector hortícola de Baja California

The Baja California produce industry is notice by its strong export orientation production. Never less, in the past few years some products have been associated to food safety outbreaks in the United States, its main market, affecting its competitiveness and market share, driven produce growers to the adoption of standards as a mean to stay in the international market. The paper focus in the role of adoption of International standards in the firms as part of a competitive strategy that implies a technological change in order to comply with the certification requirements. A descriptive statistical analysis is conducted as well as a discriminate analysis in order to explain the factors that are involved in the firms that present technical innovation (adoption of standards) to achieve competitiveness and those that don’t improve their productive process.
Multiple tail domain interactions stabilize nonmuscle myosin II bipolar filaments

Contractile force transduction by myosin II derives from its assembly into bipolar filaments. The coiled-coil tail domain of the myosin II heavy chain mediates filament assembly, although the mechanism is poorly understood. Tail domains contain an alternating electrostatic repeat, yet only a small region of the tail (termed the “assembly domain”) is typically required for assembly. Using computational analysis, mutagenesis, and electron microscopy we discovered that the assembly domain does not function through self-interaction as previously thought. Rather, the assembly domain acts as a unique, positively charged interaction surface that can stably contact multiple complementary, negatively charged surfaces in the upstream tail domain. The relative affinities of the assembly domain to each complementary interaction surface sets the characteristic molecular staggers observed in myosin II filaments. Together these results explain the relationship between the charge repeat and assembly domain in stabilizing myosin bipolar filaments.
Enriched Expression of Serotonin 1B and 2A Receptor Genes in Macaque Visual Cortex and their Bidirectional Modulatory Effects on Neuronal Responses

To study the molecular mechanism how cortical areas are specialized in adult primates, we searched for area-specific genes in macaque monkeys and found striking enrichment of serotonin (5-hydroxytryptamine, 5-HT) 1B receptor mRNA, and to a lesser extent, of 5-HT2A receptor mRNA, in the primary visual area (V1). In situ hybridization analyses revealed that both mRNA species were highly concentrated in the geniculorecipient layers IVA and IVC, where they were coexpressed in the same neurons. Monocular inactivation by tetrodotoxin injection resulted in a strong and rapid (<3 h) downregulation of these mRNAs, suggesting the retinal activity dependency of their expression. Consistent with the high expression level in V1, clear modulatory effects of 5-HT1B and 5-HT2A receptor agonists on the responses of V1 neurons were observed in in vivo electrophysiological experiments. The modulatory effect of the 5-HT1B agonist was dependent on the firing rate of the recorded neurons: The effect tended to be facilitative for neurons with a high firing rate, and suppressive for those with a low firing rate. The 5-HT2A agonist showed opposite effects. These results suggest that this serotonergic system controls the visual response in V1 for optimization of information processing toward the incoming visual inputs.
Promoting socially just and inclusive music teacher education: exploring perceptions of early-career teachers

Teacher education plays a significant role in influencing generations of future teachers. This article aims to explore the role of pre-service teacher education in promoting socially just and inclusive practices in music education. Six pre-service teachers were interviewed before graduating, and then again six months into their first year of teaching. The interviewees reflected on their understandings of what constitutes being inclusive in the music classroom and how these understandings have been influenced by their perceptions of both university and school experiences. The article provides insights into the ways that teacher education programmes might equip early-career teachers to engage in a variety of teaching practices that are socially just, within the music classroom.
ErbB2 Signaling in Schwann Cells Is Mostly Dispensable for Maintenance of Myelinated Peripheral Nerves and Proliferation of Adult Schwann Cells after Injury

Neuregulin/erbB signaling is critically required for survival and proliferation of Schwann cells as well as for establishing correct myelin thickness of peripheral nerves during development. In this study, we investigated whether erbB2 signaling in Schwann cells is also essential for the maintenance of myelinated peripheral nerves and for Schwann cell proliferation and survival after nerve injury. To this end, we used inducible Cre-loxP technology using a PLP-CreERT2 allele to ablate erbB2 in adult Schwann cells. ErbB2 expression was markedly reduced after induction of erbB2 gene disruption with no apparent effect on the maintenance of already established myelinated peripheral nerves. In contrast to development, Schwann cell proliferation and survival were not impaired in mutant animals after nerve injury, despite reduced levels of MAPK-P (phosphorylated mitogen-activated protein kinase) and cyclin D1. ErbB1 and erbB4 do not compensate for the loss of erbB2. We conclude that adult Schwann cells do not require major neuregulin signaling through erbB2 for proliferation and survival after nerve injury, in contrast to development and in cell culture.
Adventurous activities, embodiment and nature: spiritual, sensual and sustainable? Embodying environmental justice

This paper examines research on adventurous physical activities in nature from the perspective of the sentient body. Drawing upon ethnographic and autoethnographic research, I examine what has been termed 'peak' happenings or 'flow' which many who practise adventurous activities claim to experience through their whole body when in the 'zone'. I consider the concept of 'edgework', voluntary risk-taking, and insightful mobile and social understanding of the relationships between body, emotions and the elements, where the adventurous activity is experienced and interpreted as oneness with nature or expressed as 'spiritual' not only in high but also low risk nature-based sport. I then consider if and in what ways these knowledges may bring about greater understanding and action in relation to social and environmental justice. I argue that adventurous activities/nature-based sport may provide processes and practices that are alternative or complementary to traditional sporting 'body techniques' or 'body pedagogics'. I suggest that modern embodied adventurous practices in nature challenge dominant narratives of body/mind separation and potentially provide a pedagogic process fostering kinetic empathy. Finally I draw attention to the paradox of (re)-presenting sensorial experiences of sport in nature and ask for consideration on how we interconnect with the environment when we participate in adventureous nature-based sports.
A SPF-PF crossing Component Carrier joint scheduling algorithm

When adopting Carrier Aggregation (CA) in the LTE-Advanced Systems, it needs Joint Scheduling crossing multiple Component Carrier. For Component Carrier (CC) located in different frequency band, this issue presented a new Component Carrier selection algorithm-Similar Proportional Fairness (SPF) algorithm which is based on traditional scheduling algorithm of Proportional Fairness (PF) in crossing CC joint scheduling. It could calculate the users' selection weight on each Component Carrier, then combine it with PF scheduling algorithm and calculate the ultimate scheduling weight on each resource block, and allocate the resource finally. The result of simulation shows that crossing CC joint scheduling could greatly improve the throughput of the system, and compare with pre-existing Component Carrier selection algorithm, the propositional method has well fairness.
Admissibilization of Singular Interval-Valued Fuzzy Systems

In this paper, we consider the state-feedback and static output feedback control problems of continuous singular interval-valued Takagi–Sugeno fuzzy systems with mismatched membership functions. First, based on the Lyapunov stability theory, a state-feedback control criterion is proposed to guarantee the closed-loop system to be admissible. Second, the result is extended to the static output feedback control problem, and a sufficient condition for synthesis is derived in terms of strict linear matrix inequalities, which eliminates the disadvantages in some existing results, such as same output matrices and the bilinear matrix inequality problem. To obtain less conservative results, the information of mismatched membership functions is employed. Finally, numerical examples are given to illustrate the effectiveness of the proposed techniques.
ON THE INTERCHANGEABILITY OF OBJECTIVE AND SUBJECTIVE MEASURES OF EMPLOYEE PERFORMANCE: A META-ANALYSIS

A meta-analysis of studies containing both objective and subjective ratings of employee performance resulted in a corrected mean correlation of . 389. This value, although significantly greater than zero, indicates that objective and subjective performance measures should not be used interchangeably. Moreover, in no moderator subgroup examined did the correlation suggest convergent validity. After discussing issues related to resolving the previous anomalies of primary and meta-analytic results, a secondary analysis suggested that objective and subjective measures of the same construct at the same level may be used inter-changeably. The secondary analysis, however, was based on a very limited sample. Future research should address the appropriate dimensionality of employee performance.
Internal Model Control of Lightly Damped Systems Subject to Periodic Exogenous Signals

This paper presents an internal model control (IMC) design for lightly-damped systems subject to periodic exogenous signals. For such systems, the conventional design of the so-called IMC filter in the IMC structure can result in oscillatory behavior even when the closed-loop transfer function is designed to be well damped. To circumvent this problem, several band-pass filters are incorporated into the IMC filter based on knowledge of the frequencies of the plant's resonance modes and exogenous signals. The track-following system of an optical disk drive is employed to illustrate the design of the proposed IMC filter. Experimental results confirm the effectiveness of the proposed design.
Poverty and Literacy: An Introduction

Part I of the theme ‘‘Poverty and Literacy’’ begins in this issue of Reading & Writing Quarterly: Overcoming Learning Difficulties with two articles that start to examine the link between poverty and literacy. Three articles in the next issue complete our examination. Specifically, these articles collectively investigate the mutual dependence between poverty and academic achievement, creative pedagogies for low-income pupils, school models that ‘‘beat the odds,’’ and the resiliency of low-income families dedicated to the academic success of their children. Each article also explores potential roles and responsibilities of teachers, school administrators, researchers, and policymakers in closing the achievement gap and in reducing the effects of poverty on the literacy skill development of low-income children. Opinions abound about how to improve schools so that they respond to the needs of low-income children. There are those who argue for school reform, and others advocate social reform. Yet another group seeks to combine both educational reform and social reform. Regardless of where one falls on the continuum in relation to school reform, community reform, or both combined, comprehensive literacy education amounts to an essential component of any strategy focused on improving schools and closing the achievement gap. Without a strong foundation in literacy, children are all too often denied access to a rich and diverse curriculum. Reading and writing are passports to achievement in many other curricular areas (Kellett & Dar, 2007; Machin & McNally, 2006). Lastly, literacy education plays an important role in moving people out of poverty toward greater self-sufficiency post graduation. Schools and home environments share responsibility for literacy skill development. In school, literacy equals the acquisition of reading and writing skills, but it is also a social practice key to social mobility (Gee, 1991). At home children develop substantial literacy skills and unique competencies
Reliability and Structural Validity of Cross Racial Identity Scale Scores in a Sample of African American Adults

In this article, the authors examine the internal consistency and structural validity of scores on the Cross Racial Identity Scale (CRIS; Vandiver et al., 2000; Worrell, Vandiver, & Cross, 2000) in a sample of 105 adults. Exploratory factor analyses provided support for the six-factor structure of the CRIS. Reliability estimates for the scores were in the high to moderate range, and subscale inter-correlations were low. The authors conclude that the evidence supporting the CRIS is strong and recommend that the examination of CRIS scores be extended into other areas of construct validity.
Managing the career deal: the psychological contract as a framework for understanding career management, organizational commitment and work behavior

This paper reports the findings of a study that investigated the relationship between different kinds of career management activities, the psychological contract, and outcomes of psychological contract fulfillment. The study tested a series of linked hypotheses which propose that individual career management behavior is associated with the experience of organizational career management help, which is related to fulfillment of the psychological contract. Fulfillment of the psychological contract in turn is linked to organizational commitment and is associated with behaviors at work, including absenteeism, turnover, and independent ratings of job performance. The findings provide some support for these proposed links. As a result, the paper makes four contributions to the psychological contract and careers literature: first, it shows that both individual and organizational career management behaviors are linked to psychological contract fulfillment; second, organizational career management help is associated with affective commitment and job performance; third, psychological contract fulfillment plays a key role in mediating the relationship between career management help and such attitudes and behaviors; and fourth, organizational commitment may mediate between psychological contract fulfillment and individual career management behavior aimed at furthering the career outside the organization. Copyright © 2005 John Wiley & Sons, Ltd.
Going beyond cultural pluralism: Science education for sociopolitical action

Some guiding principles of antiracist education are combined with Vygotskian notions of education as enculturation in order to produce a set of proposals for a radical form of multicultural science education for sociopolitical action. Major educational goals include: raising participation and attainment levels in science for students from ethnic minority groups; and sensitizing all students to racism, and other forms of discrimination and oppression, in science and technology, science education, and contemporary society. This article outlines a radical form of curriculum development, involving the politicization of teachers, as the only effective way of implementing such a curriculum. © 1999 John Wiley & Sons, Inc. Sci Ed83:775–796, 1999.
Using Ensembles for Web Effort Estimation

Background: Despite the number of Web effort estimation techniques investigated, there is no consensus as to which technique produces the most accurate estimates, an issue shared by effort estimation in the general software estimation domain. A previous study in this domain has shown that using ensembles of estimation techniques can be used to address this issue. Aim: The aim of this paper is to investigate whether ensembles of effort estimation techniques will be similarly successful when used on Web project data. Method: The previous study built ensembles using solo effort estimation techniques that were deemed superior. In order to identify these superior techniques two approaches were investigated: The first involved replicating the methodology used in the previous study, while the second approach used the Scott-Knott algorithm. Both approaches were done using the same 90 solo estimation techniques on Web project data from the Tukutuku dataset. The replication identified 16 solo techniques that were deemed superior and were used to build 15 ensembles, while the Scott-Knott algorithm identified 19 superior solo techniques that were used to build two ensembles. Results: The ensembles produced by both approaches performed very well against solo effort estimation techniques. With the replication, the top 12 techniques were all ensembles, with the remaining 3 ensembles falling within the top 17 techniques. These 15 effort estimation ensembles, along with the 2 built by the second approach, were grouped into the best cluster of effort estimation techniques by the Scott-Knott algorithm. Conclusion: While it may not be possible to identify a single best technique, the results suggest that ensembles of estimation techniques consistently perform well even when using Web project data.
Effects of Computer-Mediated Versus Teacher-Mediated Instruction on the Mathematical Word Problem-Solving Performance of Third-Grade Students With Mathematical Difficulties

This study compared the effectiveness of computer-mediated instruction (CMI) and teacher-mediated instruction (TMI) on the word problem-solving performance of students struggling in mathematics. Both conditions integrated cognitive modeling that focused on the problem structure using visual representations with critical instructional elements specifically targeting the needs of at-risk students. Participants were 25 third-grade students with mathematics difficulties who were randomly assigned to either a TMI or a CMI condition. Results indicated no statistically significant between-condition differences at posttest and on a 4-week retention test of word problem-solving. Furthermore, there was no transfer of the word problem-solving skills to a school administered, standardized mathematics achievement test. Implications for educational practice are discussed.