Miracle-dz/UniFAR-FTUs huggingface dataset:
The South Carolina rural–urban HIV continuum of care

ABSTRACT The HIV continuum of care model is widely used by various agencies to describe the HIV epidemic in stages from diagnosis through to virologic suppression. It identifies the various points at which persons living with HIV (PLWHIV) within a population fail to reach their next step in HIV care. The rural population in the Southern United States is disproportionally affected by the HIV epidemic. The purpose of this study was to examine these rural–urban disparities using the HIV care continuum model and determine at what stages these differences become apparent. PLWHIV aged 13 years and older in South Carolina (SC) were identified using data from the enhanced HIV/AIDS Reporting System. The percentages of PLWHIV linked to care, retained in care, and virologically suppressed were determined. Rural versus urban residence was determined using the Office of Management and Budget classification. There were 14,523 PLWHIV in SC at the end of 2012; 11,193 (77%) of whom were categorized as urban and 3305 (22%) as rural. There was no difference between urban and rural for those who had received any care: 64% versus 64% (p = .61); retention in care 53% versus 53% (p = .71); and virologic suppression 49% versus 48% (p = .35), respectively. The SC rural–urban HIV cascade represents the first published cascade of care model using rural versus urban residence. Although significant health care disparities exist between rural and urban residents, there were no major differences between rural and urban residents at the various stages of engagement in HIV care using the HIV continuum of care model.
Connector design in a long-span-fixed dental prosthesis: a three-dimensional finite element analysis.

OBJECTIVES The goal of every prosthetic management is to simulate nature and be in harmony with nature within the physiological limits. The occlusal forces on a fixed dental prosthesis are transmitted to the surrounding structures through pontics, connectors and retainers and more stresses are seen at the connector region. To analyze the stress patterns in cast and soldered connectors between the two pontics and between the retainer and pontic of a four unit fixed dental prosthesis on axial and non axial loading and also to observe and ascertain the need to modify the design of the rigid connectors. MATERIALS AND METHODS Subsequently four models each of cast and soldered connectors with cylindrical and triangular design, of dimension 3 × 4 mm and thickness 0.5 mm was designed for the study. The first premolar and second molar were considered as the abutments and 2 nd premolar and 1 st molar as the pontics. The analysis was done using ANSYS version 8.0 software and by placing axial and non-axial load of 40 Newtons each. RESULTS Von Misses stresses were observed at the connector region between the two pontics, especially in the cervical region. CONCLUSION The cylindrical cast connectors showed less stress in comparison to triangular design and the difference in the stress distribution of cast and soldered connectors were marginal. CLINICAL SIGNIFICANCE The occlusal forces on a fixed dental prosthesis are transmitted to the surrounding structures through pontics, connectors and retainers with maximum stresses concentrated at the connectors. Hence this three-dimensional finite element analysis study investigated stress distribution in a four unit posterior fixed dental prosthesis, having cylindrical and triangular connector designs.
On Computing Solutions to the Continuous Time Constrained Linear Quadratic Regulator  $ $

We propose in this note a method for computing the solution to the infinite horizon continuous-time constrained linear quadratic regulator. The method is based on two main ingredients: a multigrid method for placing a finite number of time intervals, and a piece-wise linear parameterization of the input within the intervals. The input values at the decision-time points and slopes within the time intervals are computed via quadratic programs (QPs). The grids are gradually refined to efficiently improve the accuracy of the solution, and the required matrices and vectors for all QPs are computed offline and stored to improve the online efficiency. Two examples are presented to show the main characteristics of the proposed method.
Genetic Mapping and Exome Sequencing Identify Variants Associated with Five Novel Diseases

The Clinic for Special Children (CSC) has integrated biochemical and molecular methods into a rural pediatric practice serving Old Order Amish and Mennonite (Plain) children. Among the Plain people, we have used single nucleotide polymorphism (SNP) microarrays to genetically map recessive disorders to large autozygous haplotype blocks (mean = 4.4 Mb) that contain many genes (mean = 79). For some, uninformative mapping or large gene lists preclude disease-gene identification by Sanger sequencing. Seven such conditions were selected for exome sequencing at the Broad Institute; all had been previously mapped at the CSC using low density SNP microarrays coupled with autozygosity and linkage analyses. Using between 1 and 5 patient samples per disorder, we identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS. Our results reveal the power of coupling new genotyping technologies to population-specific genetic knowledge and robust clinical data.
Testing Models of Distributive Politics Using Exit Polls to Measure Voters' Preferences and Partisanship

This paper tests various hypotheses about distributive politics by studying the distribution of federal spending across U.S. states over the period 1978-2002. We improve on previous work by using survey data to measure the share of voters in each state that are Democrats, Republicans, and independents, or liberals, conservatives and moderates. We find no evidence that the allocation of federal spending to the states is distorted by strategic manipulation to win electoral support. States with many swing voters are not advantaged compared to states with more loyal voters, nor do “battleground states” attract more federal funds. Moreover, we find that spending has little or no effect on voters’ choices, whereas partisanship and ideology have massive effects.
Automating Image Analysis by Annotating Landmarks with Deep Neural Networks

Image and video analysis is often a crucial step in the study of animal behavior and kinematics. Often these analyses require that the position of one or more animal landmarks are annotated (marked) in numerous images. The process of annotating landmarks can require a significant amount of time and tedious labor, which motivates the need for algorithms that can automatically annotate landmarks. In the community of scientists that use image and video analysis to study the 3D flight of animals, there has been a trend of developing more automated approaches for annotating landmarks, yet they fall short of being generally applicable. Inspired by the success of Deep Neural Networks (DNNs) on many problems in the field of computer vision, we investigate how suitable DNNs are for accurate and automatic annotation of landmarks in video datasets representative of those collected by scientists studying animals. Our work shows, through extensive experimentation on videos of hawkmoths, that DNNs are suitable for automatic and accurate landmark localization. In particular, we show that one of our proposed DNNs is more accurate than the current best algorithm for automatic localization of landmarks on hawkmoth videos. Moreover, we demonstrate how these annotations can be used to quantitatively analyze the 3D flight of a hawkmoth. To facilitate the use of DNNs by scientists from many different fields, we provide a self contained explanation of what DNNs are, how they work, and how to apply them to other datasets using the freely available library Caffe and supplemental code that we provide.
Let My People Go: Ethnic In-Group Bias in Judicial Decisions - Evidence from a Randomized Natural Experiment

Does ethnic identity affect judicial decisions? We provide new evidence on ethnic biases in judicial behavior by examining the decisions of Arab and Jewish judges in first bail hearings of Arab and Jewish suspects in Israeli courts. Our setting avoids the potential bias from unobservable case characteristics by exploiting the random assignment of judges to cases during weekends and by focusing on the difference in ethnic disparity between Arab and Jewish judges. The study concentrates on the early-stage decisions in the judicial criminal process, controlling for the state's position and excluding agreements, thereby allowing us to distinguish judicial bias from other sources of ethnic disparities. We find systematic evidence of in-group (same ethnic group) bias in detention decisions. However, in cases where the decision is to detain, no ethnic bias was found in the length of the detention. Possible interpretations and implications of these findings are discussed.
GAYA HIDUP, MANAJEMEN KEUANGAN, STRATEGI KOPING, DAN KESEJAHTERAAN KELUARGA NELAYAN

The aim of this research was to analyze the influence of family characteristic, lifestyle, financial management, and coping strategies toward the fisherman families well-being (objective and subjective). The study involved 88 fisherman families which having school children and were chosen purposively. Data was collected by interview and analyzed by descriptive, hierarchical cluster analysis, multiple linear regression analysis, and logistic regression analysis. The research results showed that the lifestyle of fisherman families were family oriented. Financial management was categorized as medium. When they were having the decrease of income, they tend to do cutting back as coping strategies rather than generating income. Most of fisherman families are classified as nonpoor by objective indicator. The objective well-being was influenced by the family size and family income per capita per month. Meanwhile, the subjective well-being of fisherman families were categorized as medium. The subjective well-being was influenced by wifes’ age and productive oriented lifestyle.
The role of community review in evaluating the risks of human genetic variation research.

The practicality and moral value of community review of human genetic research has become a focus of debate. Examples from two Native American communities are used to address four aspects of that debate: (1) the value of community review in larger, geographically dispersed populations; (2) the identification of culturally specific risks; (3) the potential conflict between individual and group assessments of research-related risks; and (4) the confusion of social categories with biological categories. Our experiences working with these two communities suggest that: (1) successful community review may require the involvement of private social units (e.g., families); (2) culturally specific implications of genetic research may be identifiable only by community members and are of valid concern in their moral universes; (3) community concerns can be incorporated into existing review mechanisms without necessarily giving communities the power to veto research proposals; and (4) the conflation of social and biological categories presents recruitment problems for genetic studies. These conclusions argue for the use of community review to identify and minimize research-related risks posed by genetic studies. Community review also can assist in facilitating participant recruitment and retention, as well as in developing partnerships between researchers and communities.
Genomic Mechanisms Accounting for the Adaptation to Parasitism in Nematode-Trapping Fungi

Orbiliomycetes is one of the earliest diverging branches of the filamentous ascomycetes. The class contains nematode-trapping fungi that form unique infection structures, called traps, to capture and kill free-living nematodes. The traps have evolved differently along several lineages and include adhesive traps (knobs, nets or branches) and constricting rings. We show, by genome sequencing of the knob-forming species Monacrosporium haptotylum and comparison with the net-forming species Arthrobotrys oligospora, that two genomic mechanisms are likely to have been important for the adaptation to parasitism in these fungi. Firstly, the expansion of protein domain families and the large number of species-specific genes indicated that gene duplication followed by functional diversification had a major role in the evolution of the nematode-trapping fungi. Gene expression indicated that many of these genes are important for pathogenicity. Secondly, gene expression of orthologs between the two fungi during infection indicated that differential regulation was an important mechanism for the evolution of parasitism in nematode-trapping fungi. Many of the highly expressed and highly upregulated M. haptotylum transcripts during the early stages of nematode infection were species-specific and encoded small secreted proteins (SSPs) that were affected by repeat-induced point mutations (RIP). An active RIP mechanism was revealed by lack of repeats, dinucleotide bias in repeats and genes, low proportion of recent gene duplicates, and reduction of recent gene family expansions. The high expression and rapid divergence of SSPs indicate a striking similarity in the infection mechanisms of nematode-trapping fungi and plant and insect pathogens from the crown groups of the filamentous ascomycetes (Pezizomycotina). The patterns of gene family expansions in the nematode-trapping fungi were more similar to plant pathogens than to insect and animal pathogens. The observation of RIP activity in the Orbiliomycetes suggested that this mechanism was present early in the evolution of the filamentous ascomycetes.
Sunlight mediated seasonality in canopy structure and photosynthetic activity of Amazonian rainforests

Resolving the debate surrounding the nature and controls of seasonal variation in the structure and metabolism of Amazonian rainforests is critical to understanding their response to climate change. In situ studies have observed higher photosynthetic and evapotranspiration rates, increased litterfall and leaf flushing during the Sunlight-rich dry season. Satellite data also indicated higher greenness level, a proven surrogate of photosynthetic carbon fixation, and leaf area during the dry season relative to the wet season. Some recent reports suggest that rainforests display no seasonal variations and the previous results were satellite measurement artefacts. Therefore, here we re-examine several years of data from three sensors on two satellites under a range of sun positions and satellite measurement geometries and document robust evidence for a seasonal cycle in structure and greenness of wet equatorial Amazonian rainforests. This seasonal cycle is concordant with independent observations of solar radiation. We attribute alternative conclusions to an incomplete study of the seasonal cycle, i.e. the dry season only, and to prognostications based on a biased radiative transfer model. Consequently, evidence of dry season greening in geometry corrected satellite data was ignored and the absence of evidence for seasonal variation in lidar data due to noisy and saturated signals was misinterpreted as evidence of the absence of changes during the dry season. Our results, grounded in the physics of radiative transfer, buttress previous reports of dry season increases in leaf flushing, litterfall, photosynthesis and evapotranspiration in well-hydrated Amazonian rainforests.
The Timing of Divorce: Predicting When a Couple Will Divorce Over a 14‐Year Period

This paper investigates the predictability of divorce in a long-term, prospective longitudinal study. Past research has indicated that 2 periods can be considered the most critical for the survival of marriages: (a) the first 7 years of marriage, during which half of all divorces are known to occur, and (b) the period during which the first child reaches 14 years of age, which has been suggested as a low point for marital satisfaction in the life course. In the present study, interaction variables at Time 1 (both during conflict and in an events-of-the-day discussion following separation of the spouses for at least 8 hours) and noninteractive variables were used to predict divorcing both early and later in the marriage. A different set of variables predicted early divorcing than predicted later divorcing. Negative affect during conflict predicted early divorcing, but it did not predict later divorcing. By contrast, the lack of positive affect in events-of-the-day and conflict discussions predicted later divorcing, but it did not predict early divorcing. Prediction was possible over the 14-year period of the study with a model that included marital satisfaction, thoughts of marital dissolution, and affective interaction in both conversations. The model predicted divorce with 93% accuracy.
Whole Curriculum Mapping of Assessment: Cartographies of Assessment and Learning

Approaches to curriculum design often occur at the unit or course level within social work education. Only rarely have ‘whole of curriculum’ approaches been discussed in the literature. This paper describes the creation of a ‘whole of curriculum approach’ to social work teaching and learning within an Australian University. The project involved the creation of a methodology and conceptual framework to map assessment across an entire social work curriculum. In doing so, the mapping exercise provided a way to evaluate the sequencing and integration of assessment tasks across the four-year degree pathway, and judge the effectiveness that such assessments fit with theories and research on assessment more broadly, and with the graduate outcomes for a social work degree. This paper outlines the background to the 2013 assessment project and its alignment to the curriculum mapping. It argues and explains how a systematic approach to mapping and improving social work curriculums can be achieved.
Postbaccalaureate Nurse Residency 1-Year Outcomes

The authors document the 1-year outcomes of the postbaccalaureate residency program jointly developed and implemented by the University HealthSystem Consortium and the American Association of Colleges of Nursing. Data on 2 cohorts of residents (n = 679) in 12 sites across the country are presented. The 1-year termination rate was 12%, after those lost to the program because of National Council Licensure Examination failure, serious illness, or death were eliminated from the analysis. Additional analyses using data collected at entry to the program, 6 months, and 1 year using 3 instruments, the Casey-Fink Graduate Nurse Experience Survey, the Gerber's Control Over Nursing Practice Scale, and the McCloskey Mueller Satisfaction Scale, are presented and discussed.
Seasonal Timing of Reproduction in a Tropical Bird, the Seychelles Warbler: A Field Experiment Using Translocation

Reproduction of the Seychelles warbler (Acrocephalus sechellensis), a single-island endemic species living close to the equator, is characterized by a pronounced annual rhythm. The bird usually raises only one or two clutches of one egg each per year. Observational data suggest that seasonal changes in feeding conditions are an important proximate factor controlling reproduction. This hypothesis could be tested by transferring breeding pairs from Cousin Island to islands previously unoccupied at the same latitude. These islands, Aride and Cousine, have a higher food supply but similar vegetation and climate. After translocation to Aride Island, with high food availability year-round, individual breeding pairs prolonged their reproductive season (some bred year-round), increased the annual number of broods, and improved the reproductive success per nest-building attempt. Annual production of yearlings per pair on Aride was on average 23 times higher than that of the same pair on Cousin before the transfer. After translocation to Cousine Island, where food availability varied seasonally and was intermediate between Cousin and Aride, individual pairs increased the annual number of broods, but reproductive success per nest-building attempt remained the same. Annual production of yearlings per pair on Cousine was on average 5 times higher than that of the same pair on Cousin before the transfer. Thus the experiments, controlled for group size, breeding partner, breeder age, and experience, showed that food supply can be an important proximate factor in the timing of reproduction in the tropics. The differences in reproductive timing and success by warblers on the three islands are due not to genetic differences but entirely to differences in environmental conditions.
Economic Evaluations of Pharmacogenetic and Pharmacogenomic Screening Tests: A Systematic Review. Second Update of the Literature

Objective Due to extended application of pharmacogenetic and pharmacogenomic screening (PGx) tests it is important to assess whether they provide good value for money. This review provides an update of the literature. Methods A literature search was performed in PubMed and papers published between August 2010 and September 2014, investigating the cost-effectiveness of PGx screening tests, were included. Papers from 2000 until July 2010 were included via two previous systematic reviews. Studies’ overall quality was assessed with the Quality of Health Economic Studies (QHES) instrument. Results We found 38 studies, which combined with the previous 42 studies resulted in a total of 80 included studies. An average QHES score of 76 was found. Since 2010, more studies were funded by pharmaceutical companies. Most recent studies performed cost-utility analysis, univariate and probabilistic sensitivity analyses, and discussed limitations of their economic evaluations. Most studies indicated favorable cost-effectiveness. Majority of evaluations did not provide information regarding the intrinsic value of the PGx test. There were considerable differences in the costs for PGx testing. Reporting of the direction and magnitude of bias on the cost-effectiveness estimates as well as motivation for the chosen economic model and perspective were frequently missing. Conclusions Application of PGx tests was mostly found to be a cost-effective or cost-saving strategy. We found that only the minority of recent pharmacoeconomic evaluations assessed the intrinsic value of the PGx tests. There was an increase in the number of studies and in the reporting of quality associated characteristics. To improve future evaluations, scenario analysis including a broad range of PGx tests costs and equal costs of comparator drugs to assess the intrinsic value of the PGx tests, are recommended. In addition, robust clinical evidence regarding PGx tests’ efficacy remains of utmost importance.
Nuclear Localization of Senescence Marker Protein-30, SMP30, in Cultured Mouse Hepatocytes and Its Similarity to RNA Polymerase

Senescence marker protein-30 (SMP30), expressed mostly in the liver, protects cells against various injuries by stimulating membrane calcium-pump activity. By immunohistochemistry and western blotting, we found that SMP30 was in both the nuclei and cytoplasm of cultured mouse hepatocytes. By a homology search, we found that a domain of the SMP30 sequence 51 amino acid residues long was 60-66% similar to bacterial and yeast RNA polymerases.