Miracle-dz/UniFAR-FTUs huggingface dataset:
Neurological deterioration in acute ischemic stroke: potential predictors and associated factors in the European cooperative acute stroke study (ECASS) I.

BACKGROUND AND PURPOSE The present study was undertaken to identify potential predictors of and factors associated with early and late progression in acute stroke. We performed secondary analysis of the clinical, biochemical, and radiological data recorded in the acute phase of stroke patients enrolled in the European Cooperative Acute Stroke Study (ECASS) I. METHODS Early progressing stroke (EPS) was diagnosed when there was a decrease of > or = 2 points in consciousness or motor power or a decrease of > or = 3 points in speech scores in the Scandinavian Neurological Stroke Scale from baseline to the 24-hour evaluation, and late progressing stroke (LPS) was diagnosed when 1 of these decreases occurred between the 24-hour evaluation and the evaluation at day 7. Using logistic regression analyses, we looked for baseline variables that predicted EPS and LPS and for factors measured after the early or late acute phase and associated with the 2 clinical courses. RESULTS Of the 615 patients studied, 231 (37.5%) worsened during the first 24 hours after inclusion. The overall incidence of EPS was 37% in the placebo group and 38% in the recombinant tissue plasminogen activator group (P=0.68, Fisher's Exact Test). Focal hypodensity (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.3 to 2.9) and hyperdensity of the middle cerebral artery sign (OR, 1.8; 95% CI, 1.1 to 3.1) on baseline computed tomography, longer delay until treatment (OR, 1.2; 95% CI, 1.1 to 1. 4) and history of coronary heart disease (OR, 1.7; 95% CI, 1.1 to 2. 8) and diabetes (OR, 1.8; 95% CI, 1.0 to 3.1) were independent prognostic factors for EPS. Extent of hypodensity >33% in the middle cerebral artery territory (OR, 2.5; 95% CI, 1.6 to 4.0) and brain swelling (OR, 1.8; 95% CI, 1.1 to 3.2) on CT at 24 hours but not hemorrhagic transformation of cerebral infarct nor decrease in systolic blood pressure within the first 24 hours after treatment were associated with EPS in multivariate analyses. LPS was observed in 20.3% of patients. Older age, a low neurological score, and brain swelling at admission independently predicted late worsening. CONCLUSION In the setting of a multicenter trial, EPS and LPS are mainly related to computed tomographic signs of cerebral edema. Treatment with recombinant tissue plasminogen activator, hemorrhagic transformation, and moderate changes in systolic blood pressure did not influence the early clinical course.
Practical Hessian-based error control for irradiance caching

This paper introduces a new error metric for irradiance caching that significantly outperforms the classic Split-Sphere heuristic. Our new error metric builds on recent work using second order gradients (Hessians) as a principled error bound for the irradiance. We add occlusion information to the Hessian computation, which greatly improves the accuracy of the Hessian in complex scenes, and this makes it possible for the first time to use a radiometric error metric for irradiance caching. We enhance the metric making it based on the relative error in the irradiance as well as robust in the presence of black occluders. The resulting error metric is efficient to compute, numerically robust, supports elliptical error bounds and arbitrary hemispherical sample distributions, and unlike the Split-Sphere heuristic it is not necessary to arbitrarily clamp the computed error thresholds. Our results demonstrate that the new error metric outperforms existing error metrics based on the Split-Sphere model and occlusion-unaware Hessians.
Amortized efficiency of list update and paging rules

In this article we study the amortized efficiency of the “move-to-front” and similar rules for dynamically maintaining a linear list. Under the assumption that accessing the ith element from the front of the list takes &thgr;(i) time, we show that move-to-front is within a constant factor of optimum among a wide class of list maintenance rules. Other natural heuristics, such as the transpose and frequency count rules, do not share this property. We generalize our results to show that move-to-front is within a constant factor of optimum as long as the access cost is a convex function. We also study paging, a setting in which the access cost is not convex. The paging rule corresponding to move-to-front is the “least recently used” (LRU) replacement rule. We analyze the amortized complexity of LRU, showing that its efficiency differs from that of the off-line paging rule (Belady's MIN algorithm) by a factor that depends on the size of fast memory. No on-line paging algorithm has better amortized performance.
Early Caries Predicts Low Oral Health-Related Quality of Life at a Later Age

Oral health-related quality of life (OHRQOL) is the perceived impact of one's own oral health on daily life. Oral diseases influence children's OHRQOL directly, but OHRQOL might also be related to oral health experiences from the past. We investigate the relation between dental caries at the age of 6 with OHRQOL assessed at the age of 10. This study was conducted within the Generation R Study, a population-based prospective cohort study. Caries experience was assessed with the decayed, missing, and filled teeth index (dmft) at a median age of 6.09 years (90% range: 5.73-6.80). OHRQOL was assessed with a short form of the Child Oral Health Impact Profile at the children's age of 9.79 years (9.49-10.44). In total, 2,833 children participated in this study, of whom 472 (16.6%) had mild caries (dmft 1-3) and 228 (8.0%) had severe caries (dmft >3). The higher the dmft score at the age of 6, the lower the OHRQOL at the age of 10 (p < 0.001). The children with severe caries at the age of 6 had significantly higher odds of being in the lowest OHRQOL quartile at the age of 10 (OR = 1.69; 95% CI: 1.17-2.45). Our study highlights the importance of oral health during childhood, because those who get a compromised start to oral health are much more likely to follow a trajectory which will lead to poor oral health (-related QOL) later. OHRQOL is not only related to current oral health experiences but also to oral health experiences from the past.
Combustion Synthesis Reaction Behavior of Cold-Rolled Ni/Al and Ti/Al Multilayers

Abstract : A two- or three-stage combustion synthesis reaction process was observed in cold-rolled Ni/Al and Ti/Al multilayer foils. The phase evolution sequence from the two foil types was studied by differential scanning calorimetry (DSC). Several exothermic peaks were identified from the DSC thermograms. Subsequently, the foils were heated to each peak temperature to identify the reaction product associated with each peak. X-ray diffraction and scanning electron microscopy analyses were used to further discern the thermal events, whether they corresponded to intermediate or final reaction products. The Ni/Al foils went through three reaction stages. In the first stage, Al3Ni was formed as the reaction product. During the second stage, the part of the foil underwent thermal explosion. In the last stage, the heat released by the thermal explosion triggered a self-propagating high temperature synthesis reaction that resulted in the formation of AlNi. In contrast, the Ti/Al foils experienced only two reaction stages. In the first, the reaction zone propagated across the foil with formation of Al3Ti at the Ti/Al interface. Then, a thermal explosion reaction occurred in the part of foil that was heated, resulting in many different phases.
Enduring Influence of Stereotypical Computer Science Role Models on Women’s Academic Aspirations

The current work examines whether a brief exposure to a computer science role model who fits stereotypes of computer scientists has a lasting influence on women’s interest in the field. One-hundred undergraduate women who were not computer science majors met a female or male peer role model who embodied computer science stereotypes in appearance and stated interests or the same role model who did not embody these stereotypes. Participants and role models engaged in an interaction that lasted approximately 2 minutes. Interest in majoring in computer science was assessed following the interaction and 2 weeks later outside the laboratory. Results revealed that exposure to the stereotypical role model had both an immediate and an enduring negative effect on women’s interest in computer science. Differences in interest at both times were mediated by women’s reduced sense of belonging in computer science upon interacting with the stereotypical role model. Gender of the role model had no effect. Whether a potential role model conveys to women a sense of belonging in the field may matter more in recruiting women into computer science than gender of the role model. Long-term negative effects of exposure to computer scientists who fit current stereotypes in the media and elsewhere may help explain current gender disparities in computer science participation.
Reasoning about judgment and preference aggregation

Agents that must reach agreements with other agents need to reason about how their preferences, judgments, and beliefs might be aggregated with those of others by the social choice mechanisms that govern their interactions. The recently emerging field of judgment aggregation studies aggregation from a logical perspective, and considers how multiple sets of logical formulae can be aggregated to a single consistent set. As a special case, judgment aggregation can be seen to subsume classical preference aggregation. We present a modal logic that is intended to support reasoning about judgment aggregation scenarios (and hence, as a special case, about preference aggregation): the logical language is interpreted directly in judgment aggregation rules. We present a sound and complete axiomatisation of such rules. We show that the logic can express aggregation rules such as majority voting; rule properties such as independence; and results such as the discursive paradox, Arrow's theorem and Condorcet's paradox - which are derivable as formal theorems of the logic. The logic is parameterised in such a way that it can be used as a general framework for comparing the logical properties of different types of aggregation - including classical preference aggregation.
A Major Role for the Plastid-Encoded RNA Polymerase Complex in the Expression of Plastid Transfer RNAs1[W][OPEN]

Proteins that associate with the plastid-encoded RNA polymerase are required for robust expression of numerous plastid tRNAs. Chloroplast transcription in land plants relies on collaboration between a plastid-encoded RNA polymerase (PEP) of cyanobacterial ancestry and a nucleus-encoded RNA polymerase of phage ancestry. PEP associates with additional proteins that are unrelated to bacterial transcription factors, many of which have been shown to be important for PEP activity in Arabidopsis (Arabidopsis thaliana). However, the biochemical roles of these PEP-associated proteins are not known. We describe phenotypes conditioned by transposon insertions in genes encoding the maize (Zea mays) orthologs of five such proteins: ZmPTAC2, ZmMurE, ZmPTAC10, ZmPTAC12, and ZmPRIN2. These mutants have similar ivory/virescent pigmentation and similar reductions in plastid ribosomes and photosynthetic complexes. RNA gel-blot and microarray hybridizations revealed numerous changes in plastid transcript populations, many of which resemble those reported for the orthologous mutants in Arabidopsis. However, unanticipated reductions in the abundance of numerous transfer RNAs (tRNAs) dominated the microarray data and were validated on RNA gel blots. The magnitude of the deficiencies for several tRNAs was similar to that of the most severely affected messenger RNAs, with the loss of trnL-UAA being particularly severe. These findings suggest that PEP and its associated proteins are critical for the robust transcription of numerous plastid tRNAs and that this function is essential for the prodigious translation of plastid-encoded proteins that is required during the installation of the photosynthetic apparatus.
Spatial and Temporal Patterns of Dengue Transmission along a Red Sea Coastline: A Longitudinal Entomological and Serological Survey in Port Sudan City

Background Dengue is an emerging health problem in several coastlines along the Red Sea. The objective of the present work is to elucidate spatial and temporal patterns of dengue transmission in Port Sudan. Methods/Findings A longitudinal study with three cross-sectional surveys was carried out in upper, middle and lower class neighborhoods, from November 2008 to October 2009. Monthly, entomological surveys were followed by serological surveys in dengue vector-positive houses. Meteorological records were obtained from two weather stations in the city during the same time. Overall, 2825 houses were inspected. Aedes aegypti represented 65% (35,714/54,944) and 68% (2526/3715) of the collected larvae and pupae, respectively. Out of 4640 drinking water containers, 2297 were positive for Ae. aegypti. Clay-pots “Zeirr” followed by plastic barrels were key productive containers for pupae of dengue vector, 63% (n = 3959) and 26% (n = 1651), respectively. A total of 791 blood samples were tested using PanBio Capture/Indirect IgM ELISA. Overall, the sero-prevalence rate of dengue ranged between 3%–8% (41/791), compared to an incidence of 29–40 new cases per 10,000 (193/54886) in the same examined population. Lower and middle class neighborhoods had higher entomological indices compared with upper class ones (p<0.001). Although, dengue incidence rate was significantly lower in the middle and lower class neighborhoods (F = 73.97, d.f. = 2, p<0.001), no difference in IgM prevalence was shown. The city is subject to two transmission peaks in the winter (i.e. November–January), and summer (i.e. June–August). The serological peaks of dengue are preceded by entomological peaks that occur before the onset of winter (November) and summer (March) respectively. Conclusion Dengue incidence is heterogeneously distributed across the neighborhoods of Port Sudan and exhibits a bi-cyclic intra-annual pattern. Hence, it should be feasible to carry out timely vector control measures to prevent or reduce dengue transmission.
Managing a Portfolio of Real Options: Sequential Exploration of Dependent Prospects

We consider the impact of sequential investment and active management on the value of a portfolio of real options. The options are assumed to be interdependent, in that exercise of any one is assumed to produce, in addition to some intrinsic value based on an underlying asset, further information regarding the values of other options based on related assets. We couch the problem in terms of oil exploration, where a discrete number of related geological prospects are available for drilling, and management’s objective is to maximize the expected value of the combined exploration campaign. Management’s task is complex because the expected value of the investment sequence depends on the order in which options are exercised. A basic conclusion is that, although dependence increases the variance of potential outcomes, it also increases the expected value of the embedded portfolio of options and magnifies the value of optimal management. Stochastic dynamic programming techniques may be used to establish the optimal sequence of investment. Given plausible restrictions on the information structure, however, we demonstrate that the optimal dynamic program can be identified and implemented by policies that are relatively simple to execute. In other words, we provide sufficient conditions for the optimality of intuitive decision rules, like “biggest first,” “most likely first,” or “greatest intrinsic value first. ” We also develop exact analytic expressions for the implied value of the portfolio, which permits the value of active management to be assessed directly.
Do Active Surveillance and Contact Precautions Reduce MRSA Acquisition? A Prospective Interrupted Time Series

Background Consensus for methicillin-resistant Staphylococcus aureus (MRSA) control has still not been reached. We hypothesised that use of rapid MRSA detection followed by contact precautions and single room isolation would reduce MRSA acquisition. Methods This study was a pre-planned prospective interrupted time series comparing rapid PCR detection and use of long sleeved gowns and gloves (contact precautions) plus single room isolation or cohorting of MRSA colonised patients with a control group. The study took place in a medical-surgical intensive care unit of a tertiary adult hospital between May 21st 2007 and September 21st 2009. The primary outcome was the rate of MRSA acquisition. A segmented regression analysis was performed to determine the trend in MRSA acquisition rates before and after the intervention. Findings The rate of MRSA acquisition was 18.5 per 1000 at risk patient days in the control phase and 7.9 per 1000 at-risk patient days in the intervention phase, with an adjusted hazard ratio 0.39 (95% CI 0.24 to 0.62). Segmented regression analysis showed a decline in MRSA acquisition of 7% per month in the intervention phase, (95%CI 1.9% to 12.8% reduction) which was a significant change in slope compared with the control phase. Secondary analysis found prior exposure to anaerobically active antibiotics and colonization pressure were associated with increased acquisition risk. Conclusion Contact precautions with single room isolation or cohorting were associated with a 60% reduction in MRSA acquisition. While this study was a quasi-experimental design, many measures were taken to strengthen the study, such as accounting for differences in colonisation pressure, hand hygiene compliance and individual risk factors across the groups, and confining the study to one centre to reduce variation in transmission. Use of two research nurses may limit its generalisability to units in which this level of support is available.
High genetic variation in the multidrug transporter cmeB gene in Campylobacter jejuni and Campylobacter coli.

OBJECTIVES This study was conducted to examine the genetic variation occurring in the cmeB gene encoding the transporter component of the CmeABC efflux pump. METHODS Expression of the CmeABC pump in 21 strains of Campylobacter jejuni and Campylobacter coli was studied by western-blot analysis. MIC determination was conducted in the presence or absence of an efflux pump inhibitor (EPI). Inactivation of the cmeB gene and sequencing of the cmeABC operon were performed for a single strain. The remaining strains were compared by RFLP analysis of the cmeB-specific PCR amplicon. The cmeB genes of two C. coli strains with different RFLP patterns were sequenced completely. RESULTS Conflicting results were obtained in the western-blot analysis with anti-CmeB and anti-CmeC antibodies for one strain, whereas MIC determinations with EPI and cmeB gene inactivation confirmed the efflux pump's activity. The cmeB gene of this isolate showed only 78% nucleotide sequence identity with the sequence of reference strains. PCR-RFLP analysis identified 4 different patterns among the 5 C. jejuni and 14 different patterns among the 16 C. coli strains investigated. At the amino acid sequence level, variation was higher in the periplasmic loops of the transporter. CONCLUSIONS A total of 18 different cmeB-specific PCR-RFLP patterns were detected among the 21 C. jejuni and C. coli strains. These sequence variations might have an impact on the function and substrate recognition of this transporter. The sequence data obtained in this study will help to design suitable tools to study the presence or the expression of the gene cmeB.
Apolipoprotein E (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

The alleles that are detrimental to health, especially in older age, are thought to persist in populations because they also confer some benefits for individuals (through antagonistic pleiotropy). The ApoE4 allele at the ApoE locus, encoding apolipoprotein E (ApoE), significantly increases risk of poor health, and yet it is present in many populations at relatively high frequencies. Why has it not been replaced by natural selection with the health-beneficial ApoE3 allele? ApoE is a major supplier of cholesterol precursor for the production of ovarian oestrogen and progesterone, thus ApoE has been suggested as the potential candidate gene that may cause variation in reproductive performance. Our results support this hypothesis showing that in 117 regularly menstruating women those with genotypes with at least one ApoE4 allele had significantly higher levels of mean luteal progesterone (144.21 pmol l−1) than women with genotypes without ApoE4 (120.49 pmol l−1), which indicates higher potential fertility. The hormonal profiles were based on daily data for entire menstrual cycles. We suggest that the finding of higher progesterone in women with ApoE4 allele could provide first strong evidence for an evolutionary mechanism of maintaining the ancestral and health-worsening ApoE4 allele in human populations.
Resistance of leukemia cells to cytarabine chemotherapy is mediated by bone marrow stroma, involves cell-surface equilibrative nucleoside transporter-1 removal and correlates with patient outcome

The interaction between acute myeloid leukemia cells (AML) with the bone marrow stroma cells (BMSCs) determines a protective environment that favors tumor development and resistance to conventional chemotherapy. We showed that BMSCs secrete soluble factors that protect AML cells from Ara-C induced cytotoxicity. This leukemia chemoresistance is associated with a decrease in the equilibrative nucleoside transporter (ENT1) activity by inducing removal of ENT1 from the cell surface. Reduction of cell proliferation was also observed with activation of AKT and mTOR-dependent cell survival pathways, which may also contribute to the tumor chemoprotection. Analysis of primary BMSC cultures has demonstrated that AML patients with stroma capable to confer Ara-C resistance in vitro compared to AML patients without this stroma capacity were associated with a worse prognosis. The two year overall survival rate was 0% versus 80% respectively (p=0.0001). This is the first report of a chemoprotection mechanism based on the removal of a drug transporter from the cell surface and most importantly the first time that a stroma phenotype has correlated with prognostic outcome in cancer.
Frequency-domain optical measurements in vitro on two- and three-layerd tissue-like phantoms, and in vivo on infant heads

We have performed frequency-domain optical measurements on the surface of two- and three-layered turbid media (in vitro) and on infant heads (in vivo). For the in vitro experiment we measured a number of combinations of one layer (thickness in the range 0.1-1.6 cm) on top of one semi-infinite block, with or without a clear layer (thickness of 0.1 cm) sandwiched in between. For the in vivo experiment, we did measurements on 20 preterm infants at the Meyer Children's Hospital in Florence, Italy. In the two-layered samples, we measured the effective absorption and reduced scattering coefficients with a multi-distance method based on data taken at source-detector distances in the range 1.5-4.5 cm. We found that the effective optical coefficients reproduce those of the underlying block if the superficial layer is less than about 0.4 cm thick, whereas they are representative of the superficial layer if it is more than about 1.3 cm thick. Larger source detector separations reduce the effect of the superficial layer on the recovery of the effective optical coefficients. Measurements in the presence of the clear layer gave results that did not reproduce, even qualitatively, the in vivo measurements on infant heads.