Miracle-dz/UniFAR-FTUs huggingface dataset:
Insect growth regulator effects of azadirachtin and neem oil on survivorship, development and fecundity of Aphis glycines (Homoptera: Aphididae) and its predator, Harmonia axyridis (Coleoptera: Coccinellidae).

BACKGROUND Aphis glycines Matsumura, an invasive insect pest in North American soybeans, is fed upon by a key biological control agent, Harmonia axyridis Pallas. Although biological control is preferentially relied upon to suppress insect pests in organic agriculture, approved insecticides, such as neem, are periodically utilized to reduce damaging pest populations. The authors evaluated direct spray treatments of two neem formulations, azadirachtin and neem seed oil, under controlled conditions for effects on survivorship, development time and fecundity in A. glycines and H. axyridis. RESULTS Both azadirachtin and neem seed oil significantly increased aphid nymphal mortality (80 and 77% respectively) while significantly increasing development time of those surviving to adulthood. First-instar H. axyridis survival to adulthood was also significantly reduced by both neem formulations, while only azadirachtin reduced third-instar survivorship. Azadirachtin increased H. axyridis development time to adult when applied to both instars, while neem oil only increased time to adult when applied to first instar. Neither neem formulation affected the fecundity of either insect. CONCLUSIONS Results are discussed within the context of future laboratory and field studies aimed at clarifying if neem-derived insecticides can be effectively integrated with biological control for soybean aphid management in organic soybeans.
Large seasonal swings in leaf area of Amazon rainforests

Despite early speculation to the contrary, all tropical forests studied to date display seasonal variations in the presence of new leaves, flowers, and fruits. Past studies were focused on the timing of phenological events and their cues but not on the accompanying changes in leaf area that regulate vegetation–atmosphere exchanges of energy, momentum, and mass. Here we report, from analysis of 5 years of recent satellite data, seasonal swings in green leaf area of ≈25% in a majority of the Amazon rainforests. This seasonal cycle is timed to the seasonality of solar radiation in a manner that is suggestive of anticipatory and opportunistic patterns of net leaf flushing during the early to mid part of the light-rich dry season and net leaf abscission during the cloudy wet season. These seasonal swings in leaf area may be critical to initiation of the transition from dry to wet season, seasonal carbon balance between photosynthetic gains and respiratory losses, and litterfall nutrient cycling in moist tropical forests.
Effect of Ketanserin on Global Cerebral Blood Flow and Middle Cerebral Artery Flow Velocity

The aim of this study was to examine the influence of ketanserin, a 5-hydroxytryptamine antagonist antihypertensive agent, on the relationship between cerebral blood flow (CBF) and middle cerebral artery flow velocity (Vmean MCA) and to compare Doppler-sonographic indices of downstream resistance (pulsatility index, PI; resistance index, RI) with calculations of cerebrovascular resistance (CVR) in 17 male patients under fentanyl/midazolam anesthesia. CBF was measured with the Kety-Schmidt technique using argon as a tracer. Cerebral perfusion pressure (CPP) was calculated as the difference between mean arterial pressure (MAP) and jugular bulb pressure. Measurements of Vmean MCA and determinations of PI and RI were performed by use of a 2-MHz transcranial Doppler ultrasound device. All variables were measured at normo- and moderate hypocapnia before and after intravenous (IV) bolus administration of 0.3 mg/kg ketanserin followed by an infusion of 0.06 mg centered dot kg-1 centered dot h-1. Ketanserin changed neither average CBF nor Vmean MCA. The CO2 reactivity of Vmean MCA was significantly lower than the CO2 reactivity of CBF (P < 0.01); however, ketanserin did not change the relationship between CBF and Vmean MCA. During hypocapnia, CVR as well as PI and RI significantly increased (P <or=to 0.01), indicating consistent directional changes in arteriolar resistance and flow velocity pulsatility. In contrast, after IV administration of ketanserin, CVR decreased (P < 0.05), whereas both Doppler-derived indices increased (P < 0.01). These results suggest that ketanserin in a clinically relevant dose does not alter the validity of serial Vmean MCA measurements as an index of global CBF and that ketanserin does not change the diameter of middle cerebral arteries (MCAs). Doppler-derived indices of pulsatility and resistance, which are supposed to estimate changes in downstream resistance, reflect changes, after administration of ketanserin, in systemic hemodynamics rather than changes in CVR. (Anesth Analg 1995;80:64-70)
Challenges in Building an Arabic-English GHMT System with SMT Components

The research context of this paper is developing hybrid machine translation (MT) systems that exploit the advantages of linguistic rule-based and statistical MT systems. Arabic, as a morphologically rich language, is especially challenging even without addressing the hybridization question. In this paper, we describe the challenges in building an Arabic-English generation-heavy machine translation (GHMT) system and boosting it with statistical machine translation (SMT) components. We present an extensive evaluation of multiple system variants and report positive results on the advantages of hybridization.
A Concise Discrete Adaptive Filter for Frequency Estimation Under Distorted Three-Phase Voltage

To improve the control performance for grid-tied power converters, the fundamental frequency and harmonics of the grid voltage should be quickly and accurately estimated even under distorted voltage condition. This paper introduces a straightforward discrete adaptive filter to observe fundamental and harmonic sequence components of the grid voltage. The proposed filter possesses a simple and straightforward implementation. Based on the newly developed filter, frequency error transmission was analyzed when the frequency of the input voltage was unequal to the center frequency of the filter. Consequently, a frequency estimation loop was designed to adapt to the frequency variation for the filter. Compared to previous algorithms, the proposed algorithm has a better dynamic performance rating for frequency estimation, robust stability, and a simpler implementation. The effectiveness of the algorithm is verified by simulations and laboratory experiments.
Acute renal failure independently predicts mortality after myeloablative allogeneic hematopoietic cell transplant.

BACKGROUND Patients undergoing myeloablative allogeneic hematopoietic cell transplantation (HCT) have a high incidence of acute renal failure (ARF). However, it is unclear if ARF is independently associated with mortality after this procedure. METHODS We performed meta-analysis of published reports on ARF after myeloablative allogeneic HCT. Four databases (MEDLINE, Cochrane Library, PubMed, Web of Science) and hand searching of conference proceedings were used to identify the studies. ARF was defined as the doubling of serum creatinine occurring within the first 100 days after HCT. The absolute and the relative risks for death after ARF were calculated for every study. The combined relative risk was calculated using the random effects model. Also, multivariate analysis of patient level data was performed on patients from The University of Colorado to establish independent association between ARF and mortality. RESULTS One thousand two hundred and eleven patients were included in the meta-analysis from the 6 published reports in the literature. The overall incidence of ARF varied from 42% to 84% in these studies. On combining the studies by random-effects model, the relative risk of death after ARF was 2.22 (95%CI 1.38-3.5, P < 0.001). The analysis of patient level data from the University of Colorado demonstrated increasing mortality with worsening grades of ARF. After controlling for various demographic and clinical variables with logistic regression, patients who required dialysis had a 6.8-fold higher association with mortality. CONCLUSION ARF appears to independently influence mortality after myeloablative allogeneic HCT. Future studies should be aimed at interventions that can reduce the incidence and severity of ARF with this procedure.
Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group.

BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas, which are precursors of most large-bowel cancers. METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups: an intervention group given intensive counseling and assigned to follow a diet that was low in fat (20 percent of total calories) and high in fiber (18 g of dietary fiber per 1000 kcal) and fruits and vegetables (3.5 servings per 1000 kcal), and a control group given a standard brochure on healthy eating and assigned to follow their usual diet. Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps; they remained in the study for approximately four years, undergoing colonoscopy one and four years after randomization. RESULTS A total of 1905 of the randomized subjects (91.6 percent) completed the study. Of the 958 subjects in the intervention group and the 947 in the control group who completed the study, 39.7 percent and 39.5 percent, respectively, had at least one recurrent adenoma; the unadjusted risk ratio was 1.00 (95 percent confidence interval, 0.90 to 1.12). Among subjects with recurrent adenomas, the mean (+/-SE) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group. The rate of recurrence of large adenomas (with a maximal diameter of at least 1 cm) and advanced adenomas (defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia, including carcinoma) did not differ significantly between the two groups. CONCLUSIONS Adopting a diet that is low in fat and high in fiber, fruits, and vegetables does not influence the risk of recurrence of colorectal adenomas.
Integrative Physiology/Experimental Medicine Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice

Objective—We explored the effect of hydrogen sulfide (H2S) on atherosclerotic progression, particularly on intracellular adhesion molecule-1 (ICAM-1) in apolipoprotein-E knockout (apoE / ) mice and human umbilical vein endothelial cells (HUVECs). Methods and Results—ApoE / mice were treated with sodium hydrosulfide (NaHS) or DL-propargylglycine (PPG); HUVECs were pretreated with NaHS. Compared with control mice, apoE / mice showed decreased plasma H2S level and aortic H2S production but increased plasma ICAM-1 and aortic ICAM-1 protein and mRNA. Compared with apoE / mice, apoE / NaHS mice showed increased plasma H2S level, but decreased size of atherosclerotic plaque and plasma and aortic ICAM-1 levels, whereas apoE / PPG mice showed decreased plasma H2S level but enlarged plaque size and increased plasma and aortic ICAM-1 levels. NaHS suppressed ICAM-1 expression in tumor necrosis factor (TNF)–treated HUVECs. NaHS inhibited I B degradation and NFB nuclear translocation in HUVECs treated with TNF. Conclusions—The vascular CSE/H2S pathway was disturbed in apoE / mice. H2S exerted an antiatherogenic effect and inhibited ICAM-1 expression in apoE / mice. H2S inhibited ICAM-1 expression in TNF-induced HUVECs via the NFB pathway. (Arterioscler Thromb Vasc Biol. 2009;29:173-179.)
Development of Stimuli-Responsive Elastin-like Polypeptide-based Nanocomposite Biomaterials

Smart biomaterials that can actively respond to and interact with their environment are sought after for regenerative medicine, therapeutic delivery, sensing, and actuation. Polymer-nanoparticle hybrids are a promising class of smart materials, but thus far the choice of polymers has predominantly been chemically synthesized ones. In contrast, natural tissues commonly utilize proteins to interface with nanoparticles and provide smart functionalities. Inspired by nature, this dissertation describes the development of genetically engineered, protein-based polymers (PBPs) for use as components of smart, polymer-nanoparticle hybrids. Specifically, elastin-like polypeptides (ELPs), a class of thermoresponsive PBPs, were utilized to functionalize two nanoparticles.First, an improved method for synthesizing PBP genes was developed. Crafting new PBPs is limited by the ease with which their genes can be engineered. The new method utilizes a specific architecture of restriction enzymes to address some of the drawbacks of previous methods and was used to efficiently and accurately produce ELP genes.Next, ELPs were engineered to display biomimetic, bone mineral-binding peptides and their effect on therapeutic bone cements was investigated. Bones are mechanically robust, composites composed predominantly of proteins and nanocrystalline mineral. In contrast, bone cements are brittle and do not contain organic materials. Composites of mineral-binding ELPs and cement had significantly improved strength. Furthermore, the injectability and washout resistance of cements were improved as a result of the ELP's thermoresponsive behavior.Finally, photoresponsive composites were created by engineering ELPs to display graphene-binding peptides. Graphene-derived nanoparticles (GNs) exhibit unique mechanical, electrical, and optical properties but are difficult to integrate into biological systems due to their hydrophobic nature. The engineered ELPs non-covalently bound to GNs and the resulting ELP-GN hybrids exhibited increased colloidal stability and a reversible temperature-controlled aggregation behavior. The ability of GNs to convert near-infrared light to heat was exploited in order to remotely induce aggregation of ELP-GN hybrids in solution and to induce rapid, site-specific actuation of ELP-GN composite hydrogels. Finally, cell adhesion on ELP-functionalized graphene was enhanced by genetic addition of integrin-binding peptide motifs.These studies demonstrate that PBPs can be tailored to interact with nanoparticles of choice and can provide stimuli-responsive and bioactive properties to biologically relevant nanoparticles. Hybrid materials of PBPs and nanoparticles are, therefore, well suited for biotechnological applications which require smart behavior.
Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares.

BACKGROUND Central venous pressure (CVP) is used almost universally to guide fluid therapy in hospitalized patients. Both historical and recent data suggest that this approach may be flawed. OBJECTIVE A systematic review of the literature to determine the following: (1) the relationship between CVP and blood volume, (2) the ability of CVP to predict fluid responsiveness, and (3) the ability of the change in CVP (DeltaCVP) to predict fluid responsiveness. DATA SOURCES MEDLINE, Embase, Cochrane Register of Controlled Trials, and citation review of relevant primary and review articles. STUDY SELECTION Reported clinical trials that evaluated either the relationship between CVP and blood volume or reported the associated between CVP/DeltaCVP and the change in stroke volume/cardiac index following a fluid challenge. From 213 articles screened, 24 studies met our inclusion criteria and were included for data extraction. The studies included human adult subjects, healthy control subjects, and ICU and operating room patients. DATA EXTRACTION Data were abstracted on study design, study size, study setting, patient population, correlation coefficient between CVP and blood volume, correlation coefficient (or receive operator characteristic [ROC]) between CVP/DeltaCVP and change in stroke index/cardiac index, percentage of patients who responded to a fluid challenge, and baseline CVP of the fluid responders and nonresponders. Metaanalytic techniques were used to pool data. DATA SYNTHESIS The 24 studies included 803 patients; 5 studies compared CVP with measured circulating blood volume, while 19 studies determined the relationship between CVP/DeltaCVP and change in cardiac performance following a fluid challenge. The pooled correlation coefficient between CVP and measured blood volume was 0.16 (95% confidence interval [CI], 0.03 to 0.28). Overall, 56+/-16% of the patients included in this review responded to a fluid challenge. The pooled correlation coefficient between baseline CVP and change in stroke index/cardiac index was 0.18 (95% CI, 0.08 to 0.28). The pooled area under the ROC curve was 0.56 (95% CI, 0.51 to 0.61). The pooled correlation between DeltaCVP and change in stroke index/cardiac index was 0.11 (95% CI, 0.015 to 0.21). Baseline CVP was 8.7+/-2.32 mm Hg [mean+/-SD] in the responders as compared to 9.7+/-2.2 mm Hg in nonresponders (not significant). CONCLUSIONS This systematic review demonstrated a very poor relationship between CVP and blood volume as well as the inability of CVP/DeltaCVP to predict the hemodynamic response to a fluid challenge. CVP should not be used to make clinical decisions regarding fluid management.
Parallel Communication with Limited Buffers (Preliminary Version)

Currently known parallel communication schemes allow n nodes interconnected by arcs (in such a way that each node meets only a fixed number of arcs) to transmit n packets according to an arbitrary permutation in such a way that (1) only one packet is sent over a given arc at any step, (2) at most 0(log n) packets reside at a given node at any time and (3) with high probability, each packet arrives at its destination within 0(log n) steps. We present and analyze a new parallel communication scheme that ensures that at most a fixed number of packets reside at a given node at any time.
Processing of Endogenous Pre-mRNAs in Association with SC-35 Domains Is Gene Specific

Analysis of six endogenous pre-mRNAs demonstrates that localization at the periphery or within splicing factor-rich (SC-35) domains is not restricted to a few unusually abundant pre-mRNAs, but is apparently a more common paradigm of many protein-coding genes. Different genes are preferentially transcribed and their RNAs processed in different compartments relative to SC-35 domains. These differences do not simply correlate with the complexity, nuclear abundance, or position within overall nuclear space. The distribution of spliceosome assembly factor SC-35 did not simply mirror the distribution of individual pre-mRNAs, but rather suggested that individual domains contain both specific pre-mRNA(s) as well as excess splicing factors. This is consistent with a multifunctional compartment, to which some gene loci and their RNAs have access and others do not. Despite similar molar abundance in muscle fiber nuclei, nascent transcript “trees” of highly complex dystrophin RNA are cotranscriptionally spliced outside of SC-35 domains, whereas posttranscriptional “tracks” of more mature myosin heavy chain transcripts overlap domains. Further analyses supported that endogenous pre-mRNAs exhibit distinct structural organization that may reflect not only the expression and complexity of the gene, but also constraints of its chromosomal context and kinetics of its RNA metabolism.
On spectral representation for selfadjoint operators. Expansion in generalized eigenelements

Abstract : A supplement to the theory of spectral representation for selfadjoint operators in a separable Hilbert space is presented. If m is a spectral measure for the selfadjoint operator A in a Hilbert space, then the ''classical'' theory of spectral representation sets up an isometric isomorphism mapping onto a suitable space of vector-valued functions on the real line. Various results in the classical theory hold m-almost everywhere, but the exceptional sets and the relations between them were not specified. A precise description of the exceptional sets is given, the consequences of this description will be useful for questions of expansion in generalized eigenelements of A. (Author)
Pain, decisions, and actions: a motivational perspective

Because pain signals potential harm to the organism, it immediately attracts attention and motivates decisions and action. However, pain is also subject to motivations—an aspect that has led to considerable changes in our understanding of (chronic) pain over the recent years. The relationship between pain and motivational states is therefore clearly bidirectional. This review provides an overview on behavioral and neuroimaging studies investigating motivational aspects of pain. We highlight recent insights into the modulation of pain through fear and social factors, summarize findings on the role of pain in fear conditioning, avoidance learning and goal conflicts and discuss evidence on pain-related cognitive interference and motivational aspects of pain relief.
The addition of a tension night splint to a structured home rehabilitation programme in patients with chronic plantar fasciitis does not lead to significant additional benefits in either pain, function or flexibility: a single-blinded randomised controlled trial

Objective To identify any improvements in pain or function in patients with chronic plantar fasciitis following the use of a tension night splint (TNS). Methods Single-blinded randomised controlled trial, with participants split evenly between intervention group (TNS + home exercise programme/HEP) and control group (HEP only). Follow-up at 3 months, with interim data at 6 weeks. Results 40 patients recruited. Mean age 52.1 years, 33% male, mean body mass index 30.8 kg/m2, mean duration of symptoms of 25 months. Improvement in self-reported ‘average pain' in the intervention group from 6.8/10 at baseline to 5.6/10 at 6 weeks, and 5.3/10 at 3 months (both clinically and statistically significant at both time points), compared with control group of 7.1/10 at baseline to 6.2/10 at 6 weeks and 5.6/10 at 3 months (significant only at 3 months). Improvements in self-reported ‘worst pain', ‘pain walking' and ‘pain first thing in the morning' in both groups at all time periods. Improvements were seen in revised Foot Function Index at all time points in both groups, but limited changes seen in flexibility and no significant changes in anxiety or depression Hospital Anxiety and Depression Scale domains or sleep quality in either group. However, no differences were seen between the outcomes seen in the two groups for the majority of the measures studied. Conclusions Improvements in pain and some functional measures seen in both groups, with few, if any, differences seen in outcomes between the intervention group compared with the control group. However, ongoing pain symptoms were reported in both groups, suggesting that ‘help' rather than ‘cure' was obtained for the majority. There is a possibility of earlier benefit seen in the intervention group compared with the control group, but data are unclear and further work may be needed. Trial registration number ClinicalTrials.gov: NCT02546115; results.