Miracle-dz/UniFAR-FTUs huggingface dataset:
Microstructural Unit Controlling Cleavage Crack Propagation in High Strength Bainitic Steels

The strengthening mechanisms which are operative in bainite are very well known: small bainite packet, small width of the laths, dislocation density and size and number of carbide particles (Fe3C), among others. Bainite packet size has been traditionally considered as the value measured by optical microscopy (OM), as electron back scattered diffraction (EBSD) technique is relatively recent. In a V-microalloyed steel with bainitic microstructure of C=0.38%, V=0.12% and N= 0.0214% the average length and width of ferrite laths and of cementite carbides were measured. On the other hand, the bainite packet size was measured by OM and EBSD with a misorientation of 15o. These values of the microstructural units have been taken in account to calculate the effective surface energy γp given by Griffith’s model for cleavage fracture. It was concluded that bainite packet size determined by EBSD with a misorientation angle criterion of 15o was the microstructural parameter that controls cleavage crack propagation. Given the relationship between the average unit crack path (UCP) and the bainite packet size, it was concluded that the effective surface energy of cleavage fracture (γp) would be between 71.6 and 82.6 J m-2.
What Data to Co-register for Computing Atlases

We argue that registration should be thought of as a means to an end, and not as a goal by itself. In particular, we consider the problem of predicting the locations of hidden labels of a test image using observable features, given a training set with both the hidden labels and observable features. For example, the hidden labels could be segmentation labels or activation regions in fMRI, while the observable features could be sulcal geometry or MR intensity. We analyze a probabilistic framework for computing an optimal atlas, and the subsequent registration of a new subject using only the observable features to optimize the hidden label alignment to the training set. We compare two approaches for co-registering training images for the atlas construction: the traditional approach of only using observable features and a novel approach of only using hidden labels. We argue that the alternative approach is superior particularly when the relationship between the hidden labels and observable features is complex and unknown. As an application, we consider the task of registering cortical folds to optimize Brodmann area localization. We show that the alignment of the Brodmann areas improves by up to 25% when using the alternative atlas compared with the traditional atlas. To the best of our knowledge, these are the most accurate Brodmann area localization results (achieved via cortical fold registration) reported to date.
Genetic Variation at the FTO Locus Influences RBL2 Gene Expression

OBJECTIVE Genome-wide association studies that compare the statistical association between thousands of DNA variations and a human trait have detected 958 loci across 127 different diseases and traits. However, these statistical associations only provide evidence for genomic regions likely to harbor a causal gene(s) and do not directly identify such genes. We combined gene variation and expression data in a human cohort to identify causal genes. RESEARCH DESIGN AND METHODS Global gene transcription activity was obtained for each individual in a large human cohort (n = 1,240). These quantitative transcript data were tested for correlation with genotype data generated from the same individuals to identify gene expression patterns influenced by the variants. RESULTS Variant rs8050136 lies within intron 1 of the FTO gene on chromosome 16 and marks a locus strongly associated with type 2 diabetes and obesity and widely replicated across many populations. We report that genetic variation at this locus does not influence FTO gene expression levels (P = 0.38), but is strongly correlated with expression of RBL2 (P = 2.7 × 10−5), ∼270,000 base pairs distant to FTO. CONCLUSIONS These data suggest that variants at FTO influence RBL2 gene expression at large genetic distances. This observation underscores the complexity of human transcriptional regulation and highlights the utility of large human cohorts in which both genetic variation and global gene expression data are available to identify disease genes. Expedient identification of genes mediating the effects of genome-wide association study–identified loci will enable mechanism-of-action studies and accelerate understanding of human disease processes under genetic influence.
Fast Genuine Generalized Consensus

Consensus (agreeing on a sequence of commands) is central to the operation and performance of distributed systems. A well-known solution to consensus is Fast Paxos. In a recent paper, Lamport enhances Fast Paxos by leveraging the commutativity of concurrent commands. The new primitive, called Generalized Paxos, reduces the collision rate, and thus the latency of Fast Paxos. However if a collision occurs, Generalized Paxos needs four communication steps to recover, which is slower than Fast Paxos. This paper presents FGGC, a novel consensus algorithm that reduces recovery delay when a collision occurs to one. FGGC tolerates f
Bayesian Treed Gaussian Process Models With an Application to Computer Modeling

Motivated by a computer experiment for the design of a rocket booster, this article explores nonstationary modeling methodologies that couple stationary Gaussian processes with treed partitioning. Partitioning is a simple but effective method for dealing with nonstationarity. The methodological developments and statistical computing details that make this approach efficient are described in detail. In addition to providing an analysis of the rocket booster simulator, we show that our approach is effective in other arenas as well.
Promotional Reviews: An Empirical Investigation of Online Review Manipulation

Online reviews could, in principle, greatly improve consumers' ability to evaluate products. However, the authenticity of online user reviews remains a concern; firms have an incentive to manufacture positive reviews for their own products and negative reviews for their rivals. In this paper, we marry the diverse literature on economic subterfuge with the literature on organizational form. We undertake an empirical analysis of promotional reviews, examining both the extent to which fakery occurs and the market conditions that encourage or discourage promotional reviewing activity. Specifically, we examine hotel reviews, exploiting the organizational differences between two travel websites: Expedia.com and TripAdvisor.com. While anyone can post a review on TripAdvisor, a consumer can only post a review of a hotel on Expedia if she actually booked at least one night at the hotel through the website. We examine differences in the distribution of reviews for a given hotel between TripAdvisor and Expedia. We exploit the characteristics of a hotel's neighbor. We show that hotels with a nearby neighbor have more one- and two-star (negative) reviews on TripAdvisor relative to Expedia. We argue that the net gains from promotional reviewing are likely to be highest for independent hotels that are owned by single-unit owners and lowest for branded chain hotels that are owned by multi-unit owners. Our methodology thus isolates hotels with a disproportionate incentive to engage in promotional reviewing activity. We show that the hotel neighbors of hotels with a high incentive to fake have more one- and two-star (negative) reviews on TripAdvisor relative to Expedia than do hotels whose neighbors have a low incentive to fake. Furthermore, we show that hotels with a high incentive to fake have a greater share of five-star (positive) reviews on TripAdvisor relative to Expedia.
Additive models for quantile regression: Model selection and confidence bandaids

Additive models for conditional quantile functions provide an attractive framework for nonparametric regression applications focused on features of the response beyond its central tendency. Total variation roughness penalities can be used to control the smoothness of the additive components much as squared Sobelev penalties are used for classical L 2 smoothing splines. We describe a general approach to estimation and inference for additive models of this type. We focus attention primarily on selection of smoothing parameters and on the construction of confidence bands for the nonparametric components. Both pointwise and uniform confidence bands are introduced; the uniform bands are based on the Hotelling (1939) tube approach. Some simulation evidence is presented to evaluate finite sample performance and the methods are also illustrated with an application to modeling childhood malnutrition in India.
Developing a grammar checker for Swedish

A grammar checker for Swedish, launched on the market as Grammatifix, has been developed at Lingsoft in 1997-1999. This paper gives first a brief background of grammar checking projects for the Nordic languages, with an emphasis on Swedish. Then, the concept and definition of a grammar checker in general is discussed, followed by an overview of the starting points and limitations that Lingsoft had in setting up the Grammatifix development project. After this, the initial product development process is described, leading to an overview of the error types covered presently by Grammatifix. The error treatment scheme in Grammatifix is presented, with a focus on its relationship with the error detection rules. Finally, the error types included in Grammatifix are compared to those of two other known projects, namely SCARRIE and Granska.
Transition of starving Dictyostelium cells to differentiation phase at a particular position of the cell cycle.

The relationship between proliferation and differentiation in Dictyostelium discoideum Ax-2 was analyzed with reference to the cell-cycle position at the onset of starvation, using cells synchronized by temperature shift (11.5 degrees C-22.0 degrees C). To examine how far Ax-2 cells at any particular phase of the cell cycle are able to progress through the cycle in response to nutritional deprivation, we measured temporal changes in cell number and nuclearity after starvation. Nuclear DNA synthesis in synchronously developing cells was also monitored by pulse-labeling with [methyl-3H]thymidine. Increase in cell number and subsequent DNA synthesis occurred in cells just before mitosis (referred to as T0.5 cells and T1 cells; 0.5 h and 1 h after the shift-up from 11.5 degrees C to 22.0 degrees C respectively), but not in T3, T5, or T7 cells. When T1 cells were incubated for 6 h in the absence of external nutrients, they (T1 + 6 cells) exhibited developmental features similar to T7 cells, which most rapidly acquired chemotactic sensitivity to 3',5'-cyclic adenosine monophosphate (cAMP) and EDTA-resistant cohesiveness after starvation. Thus, it is quite likely that Ax-2 cells may progress through the cell cycle to a particular point (possibly the cell-cycle position of T7 cells), irrespective of the presence or absence of nutrients, and enter the differentiation phase from this point under conditions of nutritional deprivation. There was no difference in the ratio of prestalk to prespore cells in migratory pseudoplasmodia derived from cells that had been starved at other cell-cycle positions. (ABSTRACT TRUNCATED AT 250 WORDS)
Rutile from Panasqueira (Central Portugal): An Excellent Pathfinder for Wolframite Deposition

Abundant W-rich rutile in the tourmalinized wall-rocks from the Panasqueira W-deposit appears to be a marker of the onset of the main wolframite depositing event. Rutile displays spectacular zoning, both sector (SZ) and oscillatory (OZ). An extensive set of compositional data obtained on crystals, beforehand studied using back-scattered electron images and X-ray maps, was used to address (i) the effects of SZ on differential trapping of minor elements, and (ii) the significance of the OZ in deciphering fluid sources and fluid circulation dynamics. Particular attention was paid to Sn, W (Nb, Ta) concentrations in rutile as pathfinders of the W deposition. Concerning the sector zoning, W is more incorporated than (Nb, Ta) onto more efficient faces, whereas Sn contents are nearly not impacted. The net effect of the sector zoning is thus a progressive increase of the relative weight of Sn from pyramid to prism faces, in combination with a less significant increase in the relative weight of Nb + Ta. The oscillatory zoning concerns most minor elements: W, Nb (Ta), Fe, V, Cr and Sn. In the frequent doublets, the clear bands are in general enriched in W relatively to the dark ones, whereas the inverse is true for Nb and Ta. The doublets may be viewed as the result of the successive influx of (i) a W-rich, Nb + Ta poor fluid, abruptly replaced by (or mixed to) (ii) a Nb + Ta-rich and W-poor fluid. The Nb + Ta-rich fluid could be in turn related to a rare-metal granite layer observed atop of the Panasqueira granite.
Initial Implementation of a Web-Based Consultation Process for Patients With Chronic Kidney Disease

PURPOSE A Web-based consultation system (telenephrology) enables family physicians to consult a nephrologist about a patient with chronic kidney disease. Relevant data are exported from the patient’s electronic file to a protected digital environment from which advice can be formulated by the nephrologist. The primary purpose of this study was to assess the potential of telenephrology to reduce in-person referrals. METHODS In an observational, prospective study, we analyzed telenephrology consultations by 28 family practices and 5 nephrology departments in the Netherlands between May 2009 and August 2011. The primary outcome was the potential reduction of in-person referrals, measured as the difference between the number of intended referrals as stated by the family physician and the number of referrals requested by the nephrologist. The secondary outcome was the usability of the system, expressed as time invested, the implementation in daily work hours, and the response time. Furthermore, we evaluated the questions asked. RESULTS One hundred twenty-two new consultations were included in the study. In the absence of telenephrology, 43 patients (35.3%) would have been referred by their family physicians, whereas the nephrologist considered referral necessary in only 17 patients (13.9%) (P <.001). The family physician would have treated 79 patients in primary care. The nephrologist deemed referral necessary for 10 of these patients. Time investment per consultation amounted to less than 10 minutes. Consultations were mainly performed during office hours. Response time was 1.6 days (95% CI, 1.2–1.9 days). Most questions concerned estimated glomerular filtration rate, proteinuria, and blood pressure. CONCLUSION A Web-based consultation system might reduce the number of referrals and is usable. Telenephrology may contribute to an effective use of health facilities by allowing patients to be treated in primary care with remote support by a nephrologist.
Negative Energy Balance Induced by Paradoxical Sleep Deprivation Causes Multicompartmental Changes in Adipose Tissue and Skeletal Muscle

Objective. Describe multicompartmental changes in the fat and various muscle fiber types, as well as the hormonal profile and metabolic rate induced by SD in rats. Methods. Twenty adult male Wistar rats were equally distributed into two groups: experimental group (EG) and control group (CG). The EG was submitted to SD for 96 h. Blood levels of corticosterone (CORT), total testosterone (TESTO), insulin like growth factor-1 (IGF-1), and thyroid hormones (T3 and T4) were used to assess the catabolic environment. Muscle trophism was measured using a cross-sectional area of various muscles (glycolytic, mixed, and oxidative), and lipolysis was inferred by the weight of fat depots from various locations, such as subcutaneous, retroperitoneal, and epididymal. The metabolic rate was measured using oxygen consumption (V˙O2) measurement. Results. SD increased CORT levels and decreased TESTO, IGF-1, and T4. All fat depots were reduced in weight after SD. Glycolytic and mixed muscles showed atrophy, whereas atrophy was not observed in oxidative muscle. Conclusion. Our data suggest that glycolytic muscle fibers are more sensitive to atrophy than oxidative fibers during SD and that fat depots are reduced regardless of their location.
Greenlandic adoptees’ psychiatric inpatient contact. A comparative register-based study

Aims: The aim is to highlight adoptees’ and stepchildren’s psychiatric contact and diagnoses compared with non-adoptees. Methods: The setting is Greenland and the methodology is a comparative in-ward patient register-based study. The background is the Greenlandic tradition for adoption and community child care and international research stressing that adoptees demonstrate adverse health outcomes. The cohort is in-ward patients (>24 hours), born between 1973 and 2005. Correlation between various dependent and independent variables are analyzed. The research makes different comparative statements of psychiatric admissions and diagnoses related to adoptees and stepchildren compared to non-adoptees with respect to demographic and socioeconomic indicators. The psychiatric data material is collected from 1992 to 2008 and the socioeconomic indicators are included from 1996. Results: The findings show, contrary to findings related to adoptees in Western societies, that being an adoptee in Greenland does not increase the risk for psychiatric admission, but being a ‘‘female stepchild’’ does. The adjusted risk for adoptees is ‘‘non-significant’’ at 1.1 (95% confidence interval (95% CI) 0.6— 1.9) but the adjusted risk for female stepchildren is ‘‘significant’’ at 3.4 (95% CI 1.8—6.6). The most frequent diagnosis is ‘‘Inherent or acquired brain suffering’’. The findings open up possibilities for new hypotheses as to reasons for adoptees’ adverse health outcomes in the Western world. Conclusions: Epidemiological and medical contact recording do not exist outside central hospital level in Greenland, therefore, in order to put psychiatric contact patterns into perspective, in-depth field studies are required in close collaboration with the local Greenlandic population.
Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations

In children, the therapeutic benefits and potential risks associated with drug treatment may be different from those in adults and will depend on the exposure, receptor sensitivity and relationship between effect and exposure. In this paper, key factors undergoing maturational changes accounting for differences in drug metabolism and disposition in the paediatric population compared with adults are reviewed. Gastric and duodenal pH, gastric emptying time, intestinal transit time, secretion and activity of bile and pancreatic fluid, bacterial colonisation and transporters, such as P-glycoprotein (P-gp), are important factors for drug absorption, whereas key factors explaining differences in drug distribution between the paediatric population and adults are organ size, membrane permeability, plasma protein concentration and characteristics, endogenous substances in plasma, total body and extracellular water, fat content, regional blood flow and transporters such as P-gp, which is present not only in the gut, but also in liver, kidney, brain and other tissues. As far as drug metabolism is concerned, important differences have been found in the paediatric population compared with adults both for phase I enzymes (oxidative [e.g., cytochrome P450 (CYP)1A2, and CYP3A7 versus -3A4], reductive and hydrolytic enzymes) and phase II enzymes (e.g., N-methyltransferases and glucuronosyltransferases). Generally, the major enzyme differences observed in comparison with the adult age are in newborn infants, although for some enzymes (e.g., glucuronosyltransferases and other phase II enzymes) important differences still exist between infants and toddlers and adults. Finally, key factors undergoing maturational changes accounting for differences in renal excretion in the paediatric population compared with adults are glomerular filtration and tubular secretion. The ranking of the key factors varies according to the chemical structure and physicochemical properties of the drug examined, as well as to the characteristics of its formulation. It would be important to generate additional information on the developmental aspects of renal P-gp and of other renal transporters, as has been done and is still being done with the different -isozymes involved in drug metabolism.
Experimentation, Patents, and Innovation

This paper studies a simple model of experimentation and innovation. Our analysis suggests that patents may improve the allocation of resources by encouraging rapid experimentation and efficient ex post transfer of knowledge across firms. Each firm receives a private signal on the success probability of one of many potential research projects and decides when and which project to implement. A successful innovation can be copied by other firms. Symmetric equilibria (where actions do not depend on the identity of the firm) always involve delayed and staggered experimentation, whereas the optimal allocation never involves delays and may involve simultaneous rather than staggered experimentation. The social cost of insufficient experimentation can be arbitrarily large. Appropriately-designed patents can implement the socially optimal allocation (in all equilibria). In contrast to patents, subsidies to experimentation, research, or innovation cannot typically achieve this objective. We also show that when signal quality differs across firms, the equilibrium may involve a nonmonotonicity, whereby players with stronger signals may experiment after those with weaker signals. We show that in this more general environment patents again encourage experimentation and reduce delays.
A Review of the Leafhopper Genus Scaphotettix Matsumura (Hemiptera: Cicadellidae: Deltocephalinae), with Description of a New Genus

The leafhopper genus Scaphotettix Matsumura is redescribed, and three new species are described and illustrated: S. striatus Dai and Zhang, sp. nov. from Java (on bamboo) and China; S. bispinosus Dai and Zhang, sp. nov from China; and S. pectinatus Dai and Zhang, sp. nov. from Vietnam. Most other species of Scaphotettix were re-examined and found to belong to a new genus also described herein, Scaphomonus Viraktamath, gen. nov. The new genus is compared with the superficially similar Melanetettix Knight and Fletcher, Scaphodhara Viraktamath and Mohan, and Scaphoideus Uhler and a new species, Scaphomonus vateriae Viraktamath, sp. nov. from India, is described and illustrated. In addition, the following new combinations are proposed (all previously placed in Scaphotettix): Scaphomonus agumbensis (Viraktamath and Mohan) comb. nov.; S. arcuatus (Viraktamath and Mohan) comb. nov.; S. freytagi (Viraktamath and Mohan) comb. nov.; S. indicus (Distant) comb. nov.; S. longistylus (Li and Wang) comb. nov.; S. malnadicus (Viraktamath and Mohan) comb. nov.; S. quadrifidus (Viraktamath and Mohan) comb. nov.; S. redundans (Distant) comb. nov.; and S. splinterus (Li and Wang) comb. nov. Three species, Scaphotettix fanjingensis Li and Wang, Scaphotettix redstripeus Li and Wang, and Scaphotettix slenderus Li and Wang, do not belong to the genus Scaphotettix and are not treated further. Keys are provided for species of both Scaphotettix and Scaphomonus.