Miracle-dz/UniFAR-FTUs huggingface dataset:
The adoption process in management innovation: A Knowledge Management case study

This paper draws on findings from a longitudinal study of the adoption of a management innovation within an organisational setting. It is based on the findings of a case study that explores and discusses in depth a Knowledge Management programme that was introduced within a large distributed public sector agency in Europe. The aim of this research was to provide insight into the adoption process associated with management innovation. A qualitative case study strategy generates an account of the process of adoption through three phases (initiation; implementation; and outcomes), the episodes within each phase, and decision-making across the entire process. The findings contribute to the development of an extended and refined model of the process of adoption of management innovation through the consideration of the labelling, sequence and transition of phases and episodes, and decision-making. In this extended and refined model there are three phases with nine episodes, two of which are recursive; the phases occur in a linear sequence but may overlap, while the episodes occur in a non-linear sequence; and decision-making occurs within episodes, between phases and between episodes. The study makes three primary contributions to knowledge. First, it considers the process of adoption (as opposed to the more commonly examined process of generation) of management innovation. Second, it identifies decision-making related to the changes required for adoption of a management innovation. Finally, it develops a model of the process of adoption of management innovation that includes decision-making. In addition, the output of the study can be used as a tool for project management by identifying the questions to be addressed, and the decisions to be made, at particular points of the management innovation process, taking into account local contexts.
Value of In Vivo T2 Measurement for Myocardial Fibrosis Assessment in Diabetic Mice at 11.75 T

Objective:The aim of the study was to assess the value of in vivo T2 measurements to noninvasively quantify myocardial fibrosis in diabetic mice at 11.75 T. Diabetic cardiomyopathy is characterized by extracellular matrix alteration and microcirculation impairment. These conditions might provide electrical heterogeneity, which is a substrate for arrhythmogenesis. T1 mapping has been proposed to quantify diffuse myocardial fibrosis in cardiac diseases but has several limitations. T2 measurement may represent an alternative for fibrosis quantification at high magnetic field. Materials and Methods:A magnetic resonance imaging protocol including in vivo T2 measurements at 11.75 T was performed in 9 male C57BL/6J mice after 8 weeks of streptozotocin-induced diabetes and in 9 control mice. Programmed ventricular stimulation was performed in both groups. T2 measurements were compared with histologic quantification of fibrosis using picrosirius red staining. Results:Myocardial T2 was significantly lower in diabetic mice (13.8 ± 2.8 ms) than in controls (18.9 ± 2.3 ms, P < 0.001). There was a good correlation between T2 and fibrosis area obtained by histopathology (R2 = 0.947, P < 0.001). During programmed ventricular stimulation, 3 nonsustained ventricular tachycardias were induced in diabetic mice versus none in the control group. Conclusions:The in vivo T2 relaxation time strongly correlated with myocardial fibrosis area assessed with histologic staining in diabetic mice.
Origin of facies zonation in microbial carbonate platform slopes: Clues from trace element and stable isotope geochemistry (Middle Triassic, Dolomites, Italy)

Limestones containing radiaxial fibrous cements were sampled along the southern slope of the late Anisian (Middle Triassic) Latemar carbonate platform in the Dolomites, northern Italy. The Latemar upper slopes comprise massive microbial boundstone, whereas lower slopes are made of clinostratified grainstone, rudstone and breccia. Samples are representative of a seawater column from near sea‐level to an aphotic zone at about 500 m water depth. Radiaxial fibrous cements were analyzed for carbon (δ13C) and oxygen (δ18O) stable isotopic composition, as well as major and trace element content, to shed light on the origin of the slope facies zonation. The δ13C vary between 1·7‰ and 2·3‰ (Vienna Pee‐Dee Belemnite), with lowest values at palaeo‐water depths between 70 m and 300 m. Radiaxial fibrous cements yielded seawater‐like rare earth element patterns with light rare earth element depletion (NdSN/YbSN ≈ 0·4), superchondritic yttrium/holmium ratios (≈55) and negative cerium anomalies. Cadmium reaches maximum values of ca 0·5 to 0·7 μg/g at palaeo‐water depths between 70 m and 300 m; barium contents (0·8 to 1·8 μg/g) increase linearly with depth. The downslope patterns of δ13C and cadmium suggest increased nutrient and organic matter contents at depths between ca 70 m and 300 m and point to an active biological pump. The peak in cadmium and the minimum of δ13C mark a zone of maximum organic matter respiration and high nutrient and organic matter availability. The base of this zone at ca 300 m depth corresponds with the transition from massive microbial boundstone to clinostratified grainstone, rudstone and breccia. The microbial boundstone facies apparently formed only in seawater enriched in organic matter, possibly because this organic matter sustained benthic microbial communities at Latemar. The base of slope microbialites on high‐relief microbial carbonate platforms may be a proxy for the depth to maximum respiration zones of Palaeozoic and Mesozoic periplatform basins.
Gender-Specific Association between Tobacco Smoking and Central Obesity among 0.5 Million Chinese People: The China Kadoorie Biobank Study

Objectives Lifestyle factors are well-known important modifiable risk factors for obesity; the association between tobacco smoking and central obesity, however, is largely unknown in the Chinese population. This study examined the relationship between smoking and central obesity in 0.5 million Chinese adults, a population with a low prevalence of general obesity, but a high prevalence of central obesity. Subjects A total of 487,527 adults (200,564 males and 286,963 females), aged 30-79 years, were enrolled in the baseline survey of the China Kadoorie Biobank (CKB) Study conducted during 2004-2008. Waist circumference (WC) and WC/height ratio (WHtR) were used as measures of central obesity. Results The prevalence of regular smokers was significantly higher among males (60.6%) than among females (2.2%). The prevalence of central obesity increased with age and BMI levels, with a significant gender difference (females>males). Of note, almost all obese adults (99.4%) were centrally obese regardless of gender. In multivariable regression analyses, adjusting for age, education, physical activity, alcohol use and survey site, regular smoking was inversely associated with BMI in males (standardized regression coefficients, β= -0.093, p<0.001) and females (β= -0.025, p<0.001). Of interest, in the BMI stratification analyses in 18 groups, all βs of regular smoking for WHtR were positive in both genders; the βs showed a significantly greater increasing trend with increasing BMI in males than in females. In the analyses with model adjustment for BMI, the positive associations between regular smoking and WHtR were stronger in males (β= 0.021, p<0.001) than in females (β= 0.008, p<0.001) (p<0.001 for gender difference). WC showed considerably consistent results. Conclusions The data indicate that tobacco smoking is an important risk factor for central obesity, but the association is gender-specific and depends on the adjustment for general obesity.
Mammalian α-1,6-Fucosyltransferase (FUT8) Is the Sole Enzyme Responsible for the N-Acetylglucosaminyltransferase I-independent Core Fucosylation of High-mannose N-Glycans*

Understanding the biosynthetic pathway of protein glycosylation in various expression cell lines is important for controlling and modulating the glycosylation profiles of recombinant glycoproteins. We found that expression of erythropoietin (EPO) in a HEK293S N-acetylglucosaminyltransferase I (GnT I)−/− cell line resulted in production of the Man5GlcNAc2 glycoforms, in which more than 50% were core-fucosylated, implicating a clear GnT I-independent core fucosylation pathway. Expression of GM-CSF and the ectodomain of FcγIIIA receptor led to ∼30% and 3% core fucosylation, suggesting that the level of core fucosylation also depends on the nature of the recombinant proteins. To elucidate the GnT I-independent core fucosylation pathway, we generated a stable HEK293S GnT I−/− cell line with either knockdown or overexpression of FUT8 by a highly efficient lentivirus-mediated gene transfer approach. We found that the EPO produced from the FUT8 knockdown cell line was the pure Man5GlcNAc2 glycoform, whereas that produced from the FUT8-overexpressing cell line was found to be fully core-fucosylated oligomannose glycan (Man5GlcNAc2Fuc). These results provide direct evidence that FUT8, the mammalian α1,6-fucosyltransferase, is the sole enzyme responsible for the GnT I-independent core fucosylation pathway. The production of the homogeneous core-fucosylated Man5GlcNAc2 glycoform of EPO in the FUT8-overexpressed HEK293S GnT I−/− cell line represents the first example of production of fully core-fucosylated high-mannose glycoforms.
Attachment categories as reflections of multiple dimensions: comment on Fraley and Spieker (2003).

Ainsworth's system of classifying patterns of attachment behavior has served the field well and will not be easily displaced--not because of a commitment by attachment researchers to the taxonomic status of these categories but rather because of difficulties lying in the way of a dimensional approach. Foremost among these is the large number of dimensions used in making classifications and the need to develop reliable scales to tap them. Other problems include the need to capture how behavior changes across age and across the episodes of the Strange Situation. Others will debate R.C. Fraley and S.J. Spieker's (2003) arguments concerning taxonomic status. However, whether taxa or not, Ainsworth's categories at the least have represented well the multidimensional space underlying attachment behavior in conditions of mild stress. Only when an alternative approach is demonstrated to predict (with equal power, in practice) the vast range of outcomes associated with Ainsworth's categories will it be a candidate for substitution.
Narrow Bracketing and Dominated Choices 1

An experiment by Tversky and Kahneman (1981) illustrates that people's tendency to evaluate risky decisions separately can lead them to choose combinations of choices that are …rst-order stochastically dominated by other available combinations. We investigate the generality of this e¤ect both theoretically and experimentally. We show that for any decisionmaker who does not have constant-absolute-risk-averse preferences and who evaluates her decisions one by one, there exists a simple pair of independent binary decisions where the decisionmaker will make a dominated combination of choices. We also characterize, as a function of a person's preferences, the amount 1 We are grateful to experiment was made possible by the generous support of TESS (Time-Sharing Experiments in the Social Sciences) and the e¤orts by the sta¤ of Knowledge Networks. We also thank the ELSE Centre at University College London for the generous support of the laboratory experiment, and Rabin thanks the National Science Foundation for …nancial support. of money that she can lose due to a single mistake of this kind. The theory is accompanied by both a real-stakes laboratory experiment and a large-sample survey from the general U.S. population. Replicating Tversky and Kahneman's original experiment where decisionmakers with prototypical prospect-theory preferences will choose a dominated combination, we …nd that 28% of the participants do so. In the survey we ask the respondents about several hypothetical large-stakes choices, and …nd higher proportions of dominated choice combinations. A statistical model that estimates preferences from the survey results is best …t by assuming people have utility functions that are close to prospect-theory value functions and that about 83% of people bracket narrowly. None of these results varies strongly with the personal characteristics of participants. We also demonstrate directly that dominated choices are driven by narrow bracketing: when we eliminate the possibility of narrow bracketing by using a combined presentation of the decisions, the dominated choices are eliminated in the laboratory experiment and are greatly reduced in the survey.
A decentralized convergence detection algorithm for asynchronous parallel iterative algorithms

We introduce a theoretical algorithm and its practical version to perform a decentralized detection of the global convergence of parallel asynchronous iterative algorithms. We prove that, even if the algorithm is completely decentralized, the detection of global convergence is achieved on one processor under the classical conditions. The proposed algorithm is very useful in the context of grid computing in which the processors are distributed and in which detecting the convergence on a master processor may be penalizing or even impossible as in peer to peer computation frameworks. Finally, the efficiency of the practical algorithm is illustrated in a typical experiment.
The Complete Chloroplast and Mitochondrial Genomes of the Green Macroalga Ulva sp. UNA00071828 (Ulvophyceae, Chlorophyta)

Sequencing mitochondrial and chloroplast genomes has become an integral part in understanding the genomic machinery and the phylogenetic histories of green algae. Previously, only three chloroplast genomes (Oltmannsiellopsis viridis, Pseudendoclonium akinetum, and Bryopsis hypnoides) and two mitochondrial genomes (O. viridis and P. akinetum) from the class Ulvophyceae have been published. Here, we present the first chloroplast and mitochondrial genomes from the ecologically and economically important marine, green algal genus Ulva. The chloroplast genome of Ulva sp. was 99,983 bp in a circular-mapping molecule that lacked inverted repeats, and thus far, was the smallest ulvophycean plastid genome. This cpDNA was a highly compact, AT-rich genome that contained a total of 102 identified genes (71 protein-coding genes, 28 tRNA genes, and three ribosomal RNA genes). Additionally, five introns were annotated in four genes: atpA (1), petB (1), psbB (2), and rrl (1). The circular-mapping mitochondrial genome of Ulva sp. was 73,493 bp and follows the expanded pattern also seen in other ulvophyceans and trebouxiophyceans. The Ulva sp. mtDNA contained 29 protein-coding genes, 25 tRNA genes, and two rRNA genes for a total of 56 identifiable genes. Ten introns were annotated in this mtDNA: cox1 (4), atp1 (1), nad3 (1), nad5 (1), and rrs (3). Double-cut-and-join (DCJ) values showed that organellar genomes across Chlorophyta are highly rearranged, in contrast to the highly conserved organellar genomes of the red algae (Rhodophyta). A phylogenomic investigation of 51 plastid protein-coding genes showed that Ulvophyceae is not monophyletic, and also placed Oltmannsiellopsis (Oltmannsiellopsidales) and Tetraselmis (Chlorodendrophyceae) closely to Ulva (Ulvales) and Pseudendoclonium (Ulothrichales).
Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study

Background Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital-based studies suggest that African Americans may have reduced circulating natriuretic peptides, as compared to Caucasians, but definitive data from community-based cohorts are lacking. Methods and Results We examined plasma N-terminal pro B-type natriuretic peptide (NTproBNP) levels according to race in 9137 Atherosclerosis Risk in Communities (ARIC) Study participants (22% African American) without prevalent cardiovascular disease at visit 4 (1996–1998). Multivariable linear and logistic regression analyses were performed adjusting for clinical covariates. Among African Americans, percent European ancestry was determined from genetic ancestry informative markers and then examined in relation to NTproBNP levels in multivariable linear regression analysis. NTproBNP levels were significantly lower in African Americans (median, 43 pg/mL; interquartile range [IQR], 18, 88) than Caucasians (median, 68 pg/mL; IQR, 36, 124; P<0.0001). In multivariable models, adjusted log NTproBNP levels were 40% lower (95% confidence interval [CI], −43, −36) in African Americans, compared to Caucasians, which was consistent across subgroups of age, gender, HTN, diabetes, insulin resistance, and obesity. African-American race was also significantly associated with having nondetectable NTproBNP (adjusted OR, 5.74; 95% CI, 4.22, 7.80). In multivariable analyses in African Americans, a 10% increase in genetic European ancestry was associated with a 7% (95% CI, 1, 13) increase in adjusted log NTproBNP. Conclusions African Americans have lower levels of plasma NTproBNP than Caucasians, which may be partially owing to genetic variation. Low natriuretic peptide levels in African Americans may contribute to the greater risk for HTN and its sequalae in this population.
Groundwater and microbial processes of Alabama coastal plain aquifers

We integrate groundwater geochemistry, microbiology, and numerical modeling techniques to study the origin of elevated salinity and chemical evolution of groundwaters in the coastal plain aquifers of Alabama. Our field data indicate that chemical composition of groundwater evolves by various geochemical and microbial processes as it moves deeper into the subsurface. Sequential peaks of Ca2+, Mg2+, K+, and Na+ along flow paths indicate that separation of ions may be driven by cation exchange. Microbial‐mediated reactions are important for the formation of several discrete hydrochemical zones containing Fe2+, Mn2+, Sr2+, and SO42− rich groundwaters. Elevated Fe2+, Mn2+, and Sr2+ concentrations may be derived from bacterial iron and manganese reduction. High sulfate concentrations observed a short distance from the recharge may be partly explained by microbial sulfur oxidation and nitrate reduction (denitrification). The presence of denitrifying and sulfur‐oxidizing bacteria in water further supports these reactions. Major ion compositions and δD and δ18O values are used to determine the source of salinity and the nature of mixing of different groundwaters. Three water types were identified; these include carbonate groundwater, brines associated with evaporites, and groundwater of meteoric origin. Groundwater age differences and flow velocities were calculated using the 36Cl/Cl ratios. Calculated groundwater flow velocities within the Eutaw and Tuscaloosa aquifers are about 0.20 m/yr and 0.15 m/yr, respectively. We modeled basin‐scale hydrologic and solute transport processes in a cross section extending from the aquifer outcrops to the Gulf Coast. The modeling result shows that the buried Jurassic Louann Salt can significantly increase groundwater salinity in the overlying coastal plain aquifers by density‐driven advection and hydrodynamic dispersion. The modeling results are consistent with Cl/Br ratios and O/H isotope signatures, which indicate that salinity of the groundwater could be derived from seawater that has been evaporated beyond halite saturation. The predicted groundwater flow pattern reveals the mixing of meteoric water, carbonate groundwater (from the Ordovician Knox Group), and saline brines associated with the Louann Salt. The hydrologic model is consistent with the hydrochemical facies distribution in the Alabama coastal plain.
Beyond atrophy: redox mechanisms of muscle dysfunction in chronic inflammatory disease

Abstract Chronic inflammatory diseases such as heart failure, cancer and arthritis have secondary effects on skeletal muscle that cause weakness and exercise intolerance. These symptoms exacerbate illness and make death more likely. Weakness is not simply a matter of muscle atrophy. Functional studies show that contractile dysfunction, i.e. a reduction in specific force, makes an equally important contribution to overall weakness. The most clearly defined mediator of contractile dysfunction is tumour necrosis factor (TNF). TNF serum levels are elevated in chronic disease, correlate with muscle weakness, and are a predictor of morbidity and mortality. Research is beginning to unravel the mechanism by which TNF depresses specific force. TNF acts via the TNFR1 receptor subtype to depress force by increasing cytosolic oxidant activity. Oxidants depress myofibrillar function, decreasing specific force without altering calcium regulation or other aspects of myofibrillar mechanics. Beyond these concepts, the intracellular mechanisms that depress specific force remain undefined. We do not know the pathway by which receptor–ligand interaction stimulates oxidant production. Nor do we know the type(s) of oxidants stimulated by TNF, their intracellular source(s), or their molecular targets. Investigators in the field are pursuing these issues with the long‐term goal of preserving muscle function in individuals afflicted by chronic disease.
Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis

Several strains of Candida albicans were compared for their ability to cause vaginal infection in a rat model, and their vaginopathic potentials were correlated with the expression of two aspartyl proteinases genes (SAP1 and SAP2) and adherence in vivo to the vaginal epithelium. Dot blot reactions and Northern blot analysis with RNA extracted from the vaginal fluid of rats infected with the highly vaginopathic strains H12 and 10261 demonstrated the expression of both SAP1 and SAP2 during the first week of infection. In contrast, neither gene was expressed during infection by a nonvaginopathic strain (N), even though the organism could be recovered during the first 24 h postinfection. A moderately vaginopathic strain (P) also expressed both genes, but the level of SAP1 mRNA appeared to decrease prior to that of SAP2. Neither gene was expressed, even by the highly vaginopathic strains, after the first week of infection, concomitant with a decrease in the number of organisms recovered from the vaginas. Analysis of in vivo adherence showed that the nonvaginopathic strain (N) adhered to vaginal epithelial cells less readily than the highly vaginopathic strain (H12) and moderately vaginopathic strain (P). Thus, in addition to its inability to express SAP1 and SAP2 in vivo, the nonvaginopathic strain does not colonize host cells to the same extent as the other strains tested. Our results demonstrate the early in vivo expression of two aspartyl proteinase gene during candidal vaginitis and suggest its association with the establishment of a vaginal infection.