Miracle-dz/UniFAR-FTUs huggingface dataset:
Corporate Governance, Affirmative Action and Firm Value in Post-Apartheid South Africa: A Simultaneous Equation Approach

The post-Apartheid South African corporate governance (CG) model is a unique hybridisation of the traditional Anglo-American and Continental European-Asian CG models, distinctively requiring firms to explicitly comply with a number of affirmative action and stakeholder CG provisions, such as black economic empowerment, employment equity, environment, HIV/Aids, and health and safety. This paper examines the association between a composite CG index and firm value in this distinct corporate setting within a simultaneous equation framework. Using a sample of post-Apartheid South African listed corporations, and controlling for potential interdependencies among block ownership, board size, leverage, institutional ownership, firm value and a broad CG index, we find a significant positive association between a composite CG index and firm value. Further, our two-stage least squares results show that there is also a reverse association between our broad CG index and firm value, emphasising the need for future research to adequately control for potential interrelationships between possible alternative CG mechanisms and firm value. Distinct from prior studies, we find that compliance with affirmative action CG provisions impacts positively on firm value. Our results are consistent with agency, legitimacy, political cost, and resource dependence theoretical predictions. Our findings are robust across a number of econometric models that adequately control for different types of endogeneity problems, and alternative accounting, and market-based firm valuation proxies.
Circuits of Schooling: A Sociological Exploration of Parental Choice of School in Social Class Contexts

Parental choice of school is one of the main platforms of government education policy and is the centre piece of the Parents Charter. But sociological understanding of choice and choice-making is woefully underdeveloped. This paper draws on an ESRC study of market forces in education to explore social class variations in choice of school in one specific locality. The complexity of choice-making is portrayed using data from interviews with parents and it is argued that middle-class parents are taking full advantage of ‘the market’ to sustain or re-assert their class advantages.
The generality/specificity of expertise in scientific reasoning

Previous research on scientific reasoning has shown that it involves a diverse set of skills. Yet, little is known about generality or domain specificity of those skills, an important issue in theories of expertise and in attempts to automate scientific reasoning skills. We present a study designed to test what kinds of skills psychologists actually use in designing and interpreting experiments and contrast expertise within a particular research area with general expertise at designing and interpreting experiments. The results suggest that psychologists use many domain-general skills in their experimentation and that bright and motivated Carnegie Mellon undergraduates are missing many of these skills. We believe that these results have important implications for psychological and artificial intelligence models of expertise, as well as educational implications in the domain of science instruction.
Increased risk of esophageal varices, liver cancer, and death in patients with alcoholic liver disease.

BACKGROUND AND AIMS During the last decades, a multitude of different treatments for chronic liver disease have been introduced. New surveillance programs have been established to detect esophageal varices and liver cancer. The aims of our study were to assess whether the prognosis for patients hospitalized with liver diseases between 1969 and 2006 had improved and to study the differences in mortality and complications between patients with alcoholic liver disease and nonalcoholic liver diseases. METHODS We used the Swedish Hospital Discharge Register and Cause of Death Register at the National Board of Health and Welfare in Sweden between 1969 and 2006 to identify and follow-up a cohort of patients with liver disease according to the International Classification of Diseases-8, -9, and -10. RESULTS There were 36,462 patients hospitalized with alcoholic and 95,842 with nonalcoholic liver diseases. The main finding was that patients hospitalized with alcoholic liver disease had an increased mortality risk, compared to patient with nonalcoholic liver disease, 1.89 (1.85 to 1.92). In addition, the patients with alcoholic liver disease had an increased risk for esophageal varices and liver cancer. There was a reduced risk for hospitalization with esophageal varices for patients with nonalcoholic liver disease up to 1998. CONCLUSIONS We found that the prognosis for patients hospitalized with chronic liver diseases had not improved. Patients with alcoholic liver disease have an increased risk of complications, which suggest that the disease is more aggressive and are in need of closer follow-up than other chronic liver diseases.
Model/code co-refactoring: An MDE approach

Model-driven engineering suggests that models are the primary artefacts of software development. This means that models may be refactored even after code has been generated from them, in which case the code must be changed to reflect the refactoring. However, as we show neither re-generating the code from the refactored model nor applying an equivalent refactoring to the generated code is sufficient to keep model and code in sync - rather, model and code need to be refactored jointly. To enable this, we investigate the technical requirements of model/code co-refactoring, and implement a model-driven solution that we evaluate using a set of open-source programs and their structural models. Results suggest that our approach is feasible.
Dopaminergic Modulation of Working Memory for Spatial but Not Object Cues in Normal Humans

It appears that functionally segregated visual pathways exist in the primate brain for the processing of visuospatial versus nonspatial information. Functional segregation has been demonstrated for the early associative processing of sensory information but may also exist at higher levels of cognitive analysis. Namely, connections between the dorsal visual system and dorsolateral prefrontal cortex (PFC) appear to mediate spatial working memory, which is modulated by dopamine receptor fields in the principal sulcal region of the PFC. It is speculated that nonspatial working memory may be modulated within connections between ventral visual processing regions and the inferior convexity of the PFC. Whether dopamine facilitates nonspatial memory through connections between the ventral visual system and ventral PFC has not been examined. In this study, normal humans completed spatial and nonspatial working memory tasks under pharmacological challenges with a dopamine receptor agonist (bromocriptine) and antagonist (haloperidol) in a double-blind placebcxontrolled repeated measures design. Findings indicated facilitation of spatial delayed working memory functions by bromocriptine and impairment of spatial working memory functions by haloperidol. Neither drug was effective in manipulating nonspatial memory performance. Control tasks were included to measure drug effects on basic sensorimotor and attentional processes. Findings suggest that separate processing mechanisms for remembering What versus Where an object is may exist at structural, but also neurochemical, levels in the human brain.
New Three-Phase Multilevel Inverter With Reduced Number of Power Electronic Components

In this paper, a new configuration of a three-phase five-level multilevel voltage-source inverter is introduced. The proposed topology constitutes the conventional three-phase two-level bridge with three bidirectional switches. A multilevel dc link using fixed dc voltage supply and cascaded half-bridge is connected in such a way that the proposed inverter outputs the required output voltage levels. The fundamental frequency staircase modulation technique is easily used to generate the appropriate switching gate signals. For the purpose of increasing the number of voltage levels with fewer number of power electronic components, the structure of the proposed inverter is extended and different methods to determine the magnitudes of utilized dc voltage supplies are suggested. Moreover, the prototype of the suggested configuration is manufactured as the obtained simulation and hardware results ensured the feasibility of the configuration and the compatibility of the modulation technique is accurately noted.
Psychological virtues during adolescence: A longitudinal study of gender differences

Adolescence is a key stage in terms of character formation, and it is important to study positive aspects such as character strengths and virtues by means of longitudinal studies. To this end, this study uses longitudinal methodology to analyse character virtues over three consecutive years during adolescence. Participants were 282 school students, whose mean age at the first measurement point was 12.10 years. Results show that character virtues remain relatively stable between the ages of 12 and 14 years, with a slight increase over time in scores on humanity and justice. Girls scored higher than boys on all six virtues analysed, and this trend was maintained over time. The paper discusses these findings and their possible implications for achieving optimal psychological development in adolescence.
MRI intensity inhomogeneity correction by combining intensity and spatial information

We propose a novel fully automated method for retrospective correction of intensity inhomogeneity, which is an undesired phenomenon in many automatic image analysis tasks, especially if quantitative analysis is the final goal. Besides most commonly used intensity features, additional spatial image features are incorporated to improve inhomogeneity correction and to make it more dynamic, so that local intensity variations can be corrected more efficiently. The proposed method is a four-step iterative procedure in which a non-parametric inhomogeneity correction is conducted. First, the probability distribution of image intensities and corresponding second derivatives is obtained. Second, intensity correction forces, condensing the probability distribution along the intensity feature, are computed for each voxel. Third, the inhomogeneity correction field is estimated by regularization of all voxel forces, and fourth, the corresponding partial inhomogeneity correction is performed. The degree of inhomogeneity correction dynamics is determined by the size of regularization kernel. The method was qualitatively and quantitatively evaluated on simulated and real MR brain images. The obtained results show that the proposed method does not corrupt inhomogeneity-free images and successfully corrects intensity inhomogeneity artefacts even if these are more dynamic.
Differential Encoding of Losses and Gains in the Human Striatum

Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.
Identifying Leprosy and Those at Risk of Developing Leprosy by Detection of Antibodies against LID-1 and LID-NDO

Leprosy is caused by Mycobacterium leprae infection and remains a major public health problem in many areas of the world. Challenges to its timely diagnosis result in delay in treatment, which is usually associated with severe disability. Although phenolic glycolipid (PGL)-I has been reported as auxiliary diagnostic tool, currently there is no serological assay routinely used in leprosy diagnosis. The aim of this study was to evaluate the effectiveness of two related reagents, LID-1 and LID-NDO, for the detection of M. leprae infection. Sera from 98 leprosy patients, 365 household contacts (HHC) and 98 endemic controls from Rio Grande do Norte, Brazil, were evaluated. A subgroup of the HHC living in a hyperendemic area was followed for 7–10 years. Antigen-specific antibody responses were highest in multibacillary (MB) at the lepromatous pole (LL/BL) and lowest in paucibacillary (PB) at the tuberculoid pole (TT/BT). A positive correlation for both anti-LID-1 and anti-LID-NDO antibodies was found with bacterial burden (LID-1, r = 0.84, p<0.001; LID-NDO, r = 0.82, p<0.001), with higher sensitivity than bacilloscopy. According to Receiver Operating Curve, LID-1 and LID-NDO performed similarly. The sensitivity for MB cases was 89% for LID-1 and 95% for LID-NDO; the specificity was 96% for LID-1 and 88% for LID-NDO. Of the 332 HHC that were followed, 12 (3.6%) were diagnosed with leprosy in a median time of 31 (3–79) months after recruitment. A linear generalized model using LID-1 or LID-NDO as a predictor estimated that 8.3% and 10.4% of the HHC would become a leprosy case, respectively. Together, our findings support a role for the LID-1 and LID-NDO antigens in diagnosing MB leprosy and identifying people at greater risk of developing clinical disease. These assays have the potential to improve the diagnostic capacity at local health centers and aid development of strategies for the eventual control and elimination of leprosy from endemic areas.
Teachers and Researchers in Collaboration: Reflections on the Process

This research describes a 54-month National Science Foundation-supported collaboration, the Thinking Mathematics Project, between the American Federation of Teachers (AFT) and the Learning Research and Development Center (LRDC) of the University of Pittsburgh wherein expert teachers and cognitive researchers sought to codify the best of clinical and research knowledge on student learning and instruction for mathematics in the early grades. The authors draw on their documentation of the development of the collaboration between these two organizations and the teachers and researchers involved to provide highlights of participants’ reflections of the collaborative experience. Lessons about what works and what doesn’t when teachers and researchers attempt to build a common learning community are described.
Validación de la Escala de Dificultades en la Regulación Emocional en la población universitaria de Córdoba, Argentina

The purpose of the present study was to validate the Difficulties in Emotion Regulation Scale (DERS) in the university population of Cordoba, Argentina. A convenience sample of 211 undergraduates enrolled in different careers was recruited. Exploratory factor analysis yielded a six-factor structure similar to the original version which explained 50.79% of the variance. Examination of internal consistency and concurrent validity with neuroticism and extraversion traits of IPIP-FFM revealed satisfactory results. Finally, studies examining gender differences showed a significant although small difference in the factor “lack of emotional clarity” for women (t = 2.19; df = 209; p < 0.05; d = 0.17). In general, results are promising and enable the development of further researches that examine the role of difficulties in emotion regulation at the university context of Cordoba.
Quantitative analysis of cervical musculature in rats: Histochemical composition and motor pool organization. II. Deep dorsal muscles

In this paper we characterize the architecture, histochemistry, spindle composition, and motor pool organization of rat dorsal neck muscles: splenius (SP), biventer cervicis (BC) and complexus (COM). We also consider (1) whether individual rat neck muscles are innervated by more than one population of motor neurons as they are in turtles and cats and (2) whether in these muscles motor neuron size scales with muscle fiber type.
Do patients with advanced cancer and unmet palliative care needs have an interest in receiving palliative care services?

BACKGROUND It is not known whether unmet palliative care needs are associated with an interest in palliative care services among patients with advanced cancer receiving ongoing oncology care. OBJECTIVE To assess the association between unmet palliative care needs and patient interest in subspecialty palliative care services. DESIGN Cross-sectional telephone survey. SUBJECTS AND SETTING One hundred sixty-nine patients with advanced cancer receiving care from 20 oncologists at two academic cancer centers. MEASUREMENTS Surveys assessed palliative care needs in six domains. Patients were read a description of palliative care and then asked three questions about their current interest in subspecialty palliative care services (perceived need, likelihood of requesting, willingness to see if their oncologist recommended; all outcomes on 0-10 Likert scale). RESULTS The vast majority of patients described unmet palliative care needs, most commonly related to psychological/emotional distress (62%) and symptoms (62%). In fully adjusted models accounting for clustering by oncologist, unmet needs in these domains were associated with a higher perceived need for subspecialty palliative care services (psychological/emotional needs odds ratio [OR] 1.30; 95% confidence interval [CI] 1.06-1.58; p=0.01; symptom needs OR 1.27; 95% CI 1.01-1.60; p=0.04). There was no significant association between unmet needs and likelihood of requesting palliative care services. Willingness to see palliative care if oncologist recommended was high (mean 8.6/10, standard deviation [SD] 2). CONCLUSION Patients with advanced cancer and unmet symptom and psychological/emotional needs perceive a high need for subspecialty palliative care services but may not request them. Efforts to increase appropriate use of subspecialty palliative care for cancer may require oncologist-initiated referrals.
Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.

AIMS Therapeutic use of sulfhydrylated inhibitor S-zofenopril has raised different hypotheses regarding the role played by its thiol group in the beneficial clinical effects exerted compared with other angiotensin-converting enzyme (ACE) inhibitors. Here, we investigated hydrogen sulfide (H2S) pathway as accountable for extra-beneficial effects in vascular function. METHODS AND RESULTS Spontaneously hypertensive rat (SHRs) and control Wistar Kyoto (WKY) rats were treated with either S-zofenopril or enalapril in vivo. Aorta and carotid were harvested and ex vivo vascular reactivity to acetylcholine (Ach) and L-cysteine (L-cys) assessed. Cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), and 3-mercaptosulfur-transferase (3MST) expression, as well as H2S levels, were evaluated in both vascular tissues. The vascular response to Ach in both carotid and aorta was impaired in SHR (~30%, P < 0.001). S-zofenopril, but not enalapril, restored this response, while L-cys-induced relaxation was enhanced. CSE expression in vessels and tissue/plasma H2S levels were restored to WKY values in SHRs receiving S-zofenopril. In contrast, CBS and 3MST expression were not modified by treatments. S-zofenoprilat, an active metabolite of S-zofenopril, releases H2S in a 'cell-free' assay and it directly relaxed vessels in vitro in a concentration-dependent manner (P < 0.001). In vivo administration of R-zofenoprilat diasteroisomer, which does not inhibit ACE, did not modify blood pressure; nonetheless, it retained the beneficial effect on SHR vascular function as well as restored plasma/tissue H2S levels. CONCLUSION Our findings establish that S-zofenopril improves vascular function by potentiating the H2S pathway in a model of spontaneous hypertension. This novel mechanism, unrelated to ACE inhibition and based on H2S release, could explain the beneficial effects of sulfhydrylated ACE inhibitors reported in the clinical literature.
Automatic vigilance: the attention-grabbing power of negative social information.

One of the functions of automatic stimulus evaluation is to direct attention toward events that may have undesirable consequences for the perceiver's well-being. To test whether attentional resources are automatically directed away from an attended task to undesirable stimuli, Ss named the colors in which desirable and undesirable traits (e.g., honest, sadistic) appeared. Across 3 experiments, color-naming latencies were consistently longer for undesirable traits but did not differ within the desirable and undesirable categories. In Experiment 2, Ss also showed more incidental learning for undesirable traits, as predicted by the automatic vigilance (but not a perceptual defense) hypothesis. In Experiment 3, a diagnosticity (or base-rate) explanation of the vigilance effect was ruled out. The implications for deliberate processing in person perception and stereotyping are discussed.
Cytoskeleton-secretory vesicle interactions during the docking of secretory vesicles at the cell membrane in Paramecium tetraurelia cells

Stationary-phase cells of Paramecium tetraurelia have most of their many secretory vesicles ("trichocysts") attached to the cell surface. Log-phase cells contain numerous unoccupied potential docking sites for trichocysts and many free trichocysts in the cytoplasm. To study the possible involvement of cytoskeletal elements, notably of microtubules, in the process of positioning of trichocysts at the cell surface, we took advantage of these stages. Cells were stained with tannic acid and subsequently analyzed by electron microscopy. Semithin sections allowed the determination of structural connections over a range of up to 10 micrometer. Microtubules emanating from ciliary basal bodies are seen in contact with free trichocysts, which appear to be transported, with their tip first, to the cell surface. (This can account for the saltatory movement reported by others). It is noteworthy that the "rails" represented by the microtubules do not directly determine the final attachment site of a trichocyst. Unoccupied attachment sites are characterized by a "plug" of electron-dense material just below the plasma membrane; the "plug" seems to act as a recognition or anchoring site; this material is squeezed out all around the trichocyst attachment zone, once a trichocyst is inserted (Westphal and Plattner, in press. [53]). Slightly below this "plug" we observed fasciae of microfilaments (identified by immunocytochemistry using peroxidase labeled F(ab) fragments against P. tetraurelia actin). Their arrangement is not altered when a trichocyst is docked. These fasciae seem to form a loophole for the insertion of a trichocyst. Trichocyst remain attached to the microtubules originating from the ciliary basal bodies--at least for some time--even after they are firmly installed in the preformed attachment sites. Evidently, the regular arrangement of exocytotic organelles is controlled on three levels: one operating over a long distance from the exocytosis site proper (microtubules), one over a short distance (microfilament bundles), and one directly on the exocytosis site ("plug").