Miracle-dz/UniFAR-FTUs huggingface dataset:
Preterm newborn readiness for oral feeding: systematic review and meta-analysis.

PURPOSE To identify and systematize the main studies on the transition from enteral to oral feeding in preterm infants. RESEARCH STRATEGY Articles that describe the transition from oral to enteral feeding in preterm infants were located in MEDLINE, LILACS, and SciELO databases. SELECTION CRITERIA Original studies, with available abstract, published in the last 10 years were included. DATA ANALYSIS Analysis of the methodology and the main results of the studies, and meta-analysis of the effects of sensory-motor-oral stimulation at the time of transition to full oral feeding and duration of hospitalization were conducted. RESULTS Twenty-nine national and international publications were considered. Most studies were clinical trials (44.8%) and did not use rating scales to start the transition process (82.7%). In the meta-analysis, positive effect of stimulation of the sensory-motor-oral system was observed with respect to the transition time to oral diet (p=0.0000), but not in relation to the length of hospital stay (p=0.09). However, heterogeneity between studies was found both in the analysis of the transition time to full oral feeding (I2=93.98) and in the length of hospital stay (I2=82.30). CONCLUSION The transition to oral feeding is an important moment, and various physical and clinical characteristics of preterm infants have been used to describe this process. Despite the impossibility of generalizing the results due to the heterogeneity of the studies, we have noted the importance of strategies for stimulation of sensory-motor-oral system to decrease the period of transition to full oral feeding system.
Enabling an Anatomic View to Investigate Honeypot Systems: A Survey

A honeypot is a type of security facility deliberately created to be probed, attacked, and compromised. It is often used for protecting production systems by detecting and deflecting unauthorized accesses. It is also useful for investigating the behavior of attackers, and in particular, unknown attacks. For the past 17 years plenty of effort has been invested in the research and development of honeypot techniques, and they have evolved to be an increasingly powerful means of defending against the creations of the blackhat community. In this paper, by studying a wide set of honeypots, the two essential elements of honeypots—the decoy and the captor—are captured and presented, together with two abstract organizational forms—independent and cooperative—where these two elements can be integrated. A novel decoy and captor (D-C) based taxonomy is proposed for the purpose of studying and classifying the various honeypot techniques. An extensive set of independent and cooperative honeypot projects and research that cover these techniques is surveyed under the taxonomy framework. Furthermore, two subsets of features from the taxonomy are identified, which can greatly influence the honeypot performances. These two subsets of features are applied to a number of typical independent and cooperative honeypots separately in order to validate the taxonomy and predict the honeypot development trends.
Downregulation of microRNAs 145-3p and 145-5p Is a Long-term Predictor of Postmenopausal Breast Cancer Risk: The ORDET Prospective Study

Background: miRNAs have been implicated in the regulation of key metabolic, inflammatory, and malignant pathways; hence, they might be considered both predictors and players of cancer development. Methods: Using a case–control study design nested in the ORDET prospective cohort study, we addressed the possibility that specific mRNAs can serve as early predictors of breast cancer incidence in postmenopausal women. We compared leukocyte miRNA profiles of 133 incident postmenopausal breast cancer cases and profiles of 133 women who remained healthy over a follow-up period of 20 years. Results: The analysis identified 20 differentially expressed miRNAs, 15 of which were downregulated. Of the 20 miRNAs, miR145-5p and miR145-3p, each derived from another arm of the respective pre-miRNA, were consistently and significantly downregulated in all the databases that we surveyed. For example, analysis of more than 1,500 patients (the UK Metabric cohort) indicated that high abundance of miR145-3p and miR145-5p was associated with longer, and for miR145-3p also statistically significant, survival. The experimental data attributed different roles to the identified miRNAs: Although the 5p isoform was associated with invasion and metastasis, the other isoform seems related to cell proliferation. Conclusions: These observations and the prospective design of our study lend support to the hypothesis that downregulation of specific miRNAs constitutes an early event in cancer development. This finding might be used for breast cancer prevention. Impact: The identification of the miRNAs as long-term biomarkers of breast cancer may have an impact on breast cancer prevention and early detection. Cancer Epidemiol Biomarkers Prev; 23(11); 2471–81. ©2014 AACR.
Somatic alterations in juvenile polyps from BMPR1A and SMAD4 mutation carriers

Juvenile polyposis syndrome (JPS) is a rare autosomal dominant disorder predisposing to gastrointestinal hamartomatous polyps and cancer with a pathogenic SMAD4 or BMPR1A germline mutation (1st‐hit) being identified in about 40–50% of patients. Little is known, however, about the occurrence and nature of somatic alterations (2nd‐hit) in SMAD4‐/BMPR1A‐related juvenile polyps. In this study, we screened 25 polyps from three patients carrying either a pathogenic SMAD4 (c.1244‐1247delACAG) or BMPR1A (c.583C>T; p.Gln195*) germline mutation for somatic alterations. The SMAD4‐related polyps were also analyzed for SMAD4 protein expression by immunohistochemistry. Despite comprehensive screening for loss of heterozygosity (LOH), mutations in the coding sequence, chromosomal rearrangements, and promoter methylation, no somatic alterations could be identified in 14 SMAD4‐related polyps. SMAD4 protein expression, however, was lost in 8 (57%) of 14 juvenile polyps with 6 showing concomitant loss in both, the epithelial and stromal, compartments. In the BMPR1A‐related polyps, five out of nine (56%) displayed LOH. Further analysis of selected polyps revealed that LOH was gene copy number neutral and had occurred in the epithelial compartment. The heterogeneity of genetic mutations and protein expression levels indicates that different modes of gene inactivation can be operational in SMAD4‐ and BMPR1A‐related polyp formation. Our observation, that about half of BMPR1A‐related polyps displayed LOH, predominantly in the epithelial compartment, is compatible with BMPR1A acting as a tumour suppressor gene. Still, it remains to be determined whether juvenile polyp development generally requires loss of BMPR1A expression or, as observed in some SMAD4‐related polyps, can occur despite normal protein expression. © 2015 Wiley Periodicals, Inc.
Advanced Pultruded Glass Fibers-Reinforced Isophtalic Polyester Resin

Within this paper an experimental analysis of an advanced composite U-beam pultruded profile based on isophtalic polyester resin reinforced with unidirectional glass fibres and overlay veil has been carried out to determine its most important mechanical properties. Tensile tests have been accomplished on specimens cut from the pultruded profile along and transverse to the fibers direction. Over thirty mechanical properties including Young’s moduli, stiffness, load-extension as well as stress-strain distributions determined at maximum load, maximum extension and at break have been determined on a Lloyd Instruments LS100KPlus materials testing machine. Typical failure mechanisms such as fibres pull-out and delaminations have been noticed. The tests show that this kind of unidirectional glass fibers-reinforced isophtalic polyester resin with overlay veil obtained in the putrusion process is suitable for a large range of applications from the automotive and aerospace industry and put into evidence its strong anisotropy.
Retinal blood vessel segmentation based on the Gaussian matched filter and U-net

The automatic segmentation of retinal vessels plays an important role in the early screening of eye diseases. However, pathological retinal images are difficult for us to segment the vessels. In this paper, we regard the vessels segmentation task as a multi-label problem and combine the preprocessed method Gaussian matched filter with a new U-shaped fully convolutional neural network called U-net to generate a blood vessels segmentation framework. The output of this model can distinguish the vessels from background although in the inadequate contrast regions and pathological regions. The proposed method is tested on a publicly available dataset of DRIVE. Sensitivity, Specificity, Accuracy and Precision are used to evaluate our method, and the average classification accuracy is 0.9636 on the dataset of DRIVE. Performance results show that our method outperforms the state-of-the-art method for automatic retinal blood segmentation.
Simulating ozone dry deposition at a boreal forest with a multi-layer canopy deposition model

Abstract. A multi-layer ozone (O3) dry deposition model has been implemented into SOSAA (a model to Simulate the concentrations of Organic vapours, Sulphuric Acid and Aerosols) to improve the representation of O3 concentration and flux within and above the forest canopy in the planetary boundary layer. We aim to predict the O3 uptake by a boreal forest canopy under varying environmental conditions and analyse the influence of different factors on total O3 uptake by the canopy as well as the vertical distribution of deposition sinks inside the canopy. The newly implemented dry deposition model was validated by an extensive comparison of simulated and observed O3 turbulent fluxes and concentration profiles within and above the boreal forest canopy at SMEAR II (Station to Measure Ecosystem–Atmosphere Relations II) in Hyytiala, Finland, in August 2010. In this model, the fraction of wet surface on vegetation leaves was parametrised according to the ambient relative humidity (RH). Model results showed that when RH was larger than 70 % the O3 uptake onto wet skin contributed ∼ 51 % to the total deposition during nighttime and ∼ 19 % during daytime. The overall contribution of soil uptake was estimated about 36 %. The contribution of sub-canopy deposition below 4.2 m was modelled to be ∼ 38 % of the total O3 deposition during daytime, which was similar to the contribution reported in previous studies. The chemical contribution to O3 removal was evaluated directly in the model simulations. According to the simulated averaged diurnal cycle the net chemical production of O3 compensated up to ∼ 4 % of dry deposition loss from about 06:00 to 15:00 LT. During nighttime, the net chemical loss of O3 further enhanced removal by dry deposition by a maximum ∼ 9 %. Thus the results indicated an overall relatively small contribution of airborne chemical processes to O3 removal at this site.
Fluorescence-Based Quasicontinuous and In Situ Monitoring of Biofilm Formation Dynamics in Natural Marine Environments

ABSTRACT Analyzing the dynamics of biofilm formation helps to deepen our understanding of surface colonization in natural environments. While methods for screening biofilm formation in the laboratory are well established, studies in marine environments have so far been based upon destructive analysis of individual samples and provide only discontinuous snapshots of biofilm establishment. In order to explore the development of biofilm over time and under various biotic and abiotic conditions, we applied a recently developed optical biofilm sensor to quasicontinuously analyze marine biofilm dynamics in situ. Using this technique in combination with microscope-assisted imaging, we investigated biofilm formation from its beginning to mature multispecies biofilms. In contrast to laboratory studies on biofilm formation, a smooth transition from initial attachment to colony formation and exponential growth could not be observed in the marine environment. Instead, initial attachment was followed by an adaptation phase of low growth and homogeneously distributed solitary bacterial cells. Moreover, we observed a diurnal variation of biofilm signal intensity, suggesting a transient state of biofilm formation of bacteria. Overall, the biofilm formation dynamics could be modeled by three consecutive development stages attributed to initial bacterial attachment, bacterial growth, and attachment and growth of unicellular eukaryotic microorganisms. Additional experiments showed that the presence of seaweed considerably shortened the adaptation phase in comparison with that on control surfaces but yielded similar growth rates. The outlined examples highlight the advantages of a quasicontinuous in situ detection that enabled, for the first time, the exploration of the initial attachment phase and the diurnal variation during biofilm formation in natural ecosystems.
A Demonstration That Large-Scale Warming Is Not Urban

Abstract On the premise that urban heat islands are strongest in calm conditions but are largely absent in windy weather, daily minimum and maximum air temperatures for the period 1950–2000 at a worldwide selection of land stations are analyzed separately for windy and calm conditions, and the global and regional trends are compared. The trends in temperature are almost unaffected by this subsampling, indicating that urban development and other local or instrumental influences have contributed little overall to the observed warming trends. The trends of temperature averaged over the selected land stations worldwide are in close agreement with published trends based on much more complete networks, indicating that the smaller selection used here is sufficient for reliable sampling of global trends as well as interannual variations. A small tendency for windy days to have warmed more than other days in winter over Eurasia is the opposite of that expected from urbanization and is likely to be a consequence of.
An in vitro prototype of a porcine biomimetic testis-like cell culture system: a novel tool for the study of reassembled Sertoli and Leydig cells

At present, there is no reliable in vitro assembled prepubertal testis-like biomimetic organ culture system designed to assess the functional effects of human gonadotropins on Sertoli and Leydig cells. Spermatogenesis is regulated by endocrine, paracrine, and juxtacrine factors (testicular cross-talk), mainly orchestrated by gonadotropins such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that play a pivotal role by stimulating Leydig and Sertoli cells, respectively. The aim of our study was to set up an in vitro prepubertal porcine bioengineered construct as a new model for experimental studies on reassembled Sertoli and Leydig cells. We have evaluated Sertoli and Leydig cells obtained from 15- to 20-day-old neonatal pig testes in terms of purity and function. Subsequently, purified Sertoli and enriched Leydig cells were subjected to coincubation to obtain an in vitro prepubertal porcine testis-like culture system. We performed enzyme-linked immunosorbent assay (ELISA) for anti-Müllerian hormone (AMH), inhibin B, and testosterone secretion in the medium, and Real-Time PCR analysis of AMH, inhibin B, FSH-r, aromatase, LHr, and 3β-HSD mRNA expression levels. This in vitro testis-like system was highly responsive to the effects of human gonadotropins and testosterone. AMH mRNA expression and secretion declined, and inhibin-B increased, while FSH-receptor expression was downregulated upon FSH/LH exposure/treatment. Finally, the production of testosterone was increased selectively upon LH treatment. In summary, our proposed model could help to better determine the action of human gonadotropins on Sertoli and Leydig cells. The potential usefulness of the system for shedding light into male infertility-related issues is evident.
NorLeu3A(1-7) Accelerates Clear Corneal Full Thickness Wound Healing.

PURPOSE We evaluated the effect of the renin angiotensin system (RAS) peptide NorLeu3-Angiotensin (1-7) (NLE) formulated in a viscoelastic gel (USB004) on the healing of full-thickness corneal injuries. METHODS Dutch pigmented rabbits received conjunctival administration of 0.3% USB004, 0.03% USB004, or vehicle-control to healthy and full-thickness injured eyes administered once daily for 28 consecutive days. Safety was evaluated using IOP measurement, slit-lamp examination, and confocal microscopy. Evaluations for both efficacy studies included an oblique light examination, modified Seidel test (Seidel test with gentle ocular pressure) as well as during elevated IOP test, confocal microscopy imaging, and histologic analysis. RESULTS Application of 0.3% USB004, 0.03% USB004, and vehicle-control was safe in healthy and incised eyes. Further, application of 0.3% and 0.03% USB004 following full-thickness corneal incision resulted in a 2-fold acceleration of resolution of edema and inflammation, reduction in duration of wound leakage on a modified Seidel test (Seidel test with gentle ocular pressure) as well as during elevated IOP test, and healing with near normal architecture without evidence of fibrosis and angiogenesis when compared to vehicle-control animals. CONCLUSIONS Topical ocular application of 0.3% and 0.03% USB004 promotes full-thickness cornea wound healing without the evidence of fibrosis and angiogenesis. Further studies are warranted to determine the cornea-specific mechanism of action(s) that promotes regeneration leading to clear corneal healing.
In situ monitoring of isophorone diisocyanate-based flexible polyurethane foams formation

Novel isophorone diisocyanate-based flexible polyurethane foams were prepared by the one-step method in a computerized foam qualification system (FOAMAT). The experimental conditions to obtain this type of foams, in relation to the nature and concentration of catalysts as well as the reaction temperature, were established as no data were available in scientific literature. The chemical reactions occurring during the foam generation process were monitored in situ by attenuated total reflectance-FTIR spectroscopy. The kinetics of the foam generation was fitted to an nth order model and the data showed that the foaming process adjusted to a first-order kinetics. The physical changes as pressure, foam height, and dielectric polarization were monitored by the FOAM software (FOAMAT). According to these parameters, the foaming process was divided into four steps: bubble growth, bubble packing, cell opening, and final curing.
Acceptability and feasibility of a social entrepreneurship testing model to promote HIV self‐testing and linkage to care among men who have sex with men

HIV self‐testing (HIVST) offers an opportunity to increase HIV testing among people not reached by facility‐based services. However, the promotion of HIVST is limited as a consequence of insufficient community engagement. We built a social entrepreneurship testing (SET) model to promote HIVST linkage to care among Chinese men who have sex with men (MSM) in Guangzhou.
Comparisons of Mixed-Phase Icing Cloud Simulations with Experiments Conducted at the NASA Propulsion Systems Laboratory

This paper presents the evaluation of a numerical model for simulation of the icing cloud development at NASA Glenn Research Propulsion Systems Laboratory (PSL). The model is helping the icing facility and the fundamental ice-crystal icing physics research team to better understand the complex interactions between the test parameters and have greater confidence in the conditions at the test section of the PSL tunnel. The model attempts to explain the observed changes in test conditions by coupling the conservation of mass and energy equations for both the cloud particles and flowing air, while accounting for compressibility and the variable PSL geometry. A subroutine has been added to more accurately simulate the tunnel when water vapor conditions potentially exceed saturation. The model simulation results are compared to experimentally measured values that were taken during the first fundamentals of ice-crystal icing physics tests conducted at PSL in March 2016. The tests simulated ice-crystal and mixed-phase icing that relate to ice accretions within turbofan engines. Experimentally measured air temperature, humidity, total water content, liquid and ice water content, as well as cloud particle size, are compared with model predictions. The model showed good trend agreement with experimentally measured values, but often over-predicted aero-thermodynamic changes. This discrepancy is likely attributed to radial variations that this one-dimensional model does not address. One of the key findings of this work is that greater aero-thermodynamic changes occur when humidity conditions are low. In addition a range of mixed-phase clouds can be achieved by varying only the tunnel humidity conditions, but the range of humidities to generate a mixed-phase cloud becomes smaller when clouds are composed of smaller particles. In general, the model predicted melt fraction well, in particular with clouds composed of larger particle sizes.
Characterizing the Design Space of Rendered Robot Faces

Faces are critical in establishing the agency of social robots; however, building expressive mechanical faces is costly and difficult. Instead, many robots built in recent years have faces that are rendered onto a screen. This gives great flexibility in what a robot’s face can be and opens up a new design space with which to establish a robot’s character and perceived properties. Despite the prevalence of robots with rendered faces, there are no systematic explorations of this design space. Our work aims to fill that gap. We conducted a survey and identified 157 robots with rendered faces and coded them in terms of 76 properties. We present statistics, common patterns, and observations about this data set of faces. Next, we conducted two surveys to understand people’s perceptions of rendered robot faces and identify the impact of different face features. Survey results indicate preferences for varying levels of realism and detail in robot faces based on context, and indicate how the presence or absence of specific features affects perception of the face and the types of jobs the face would be appropriate for.
Genetic and environmental risk factors for developmental dyslexia in children: systematic review of the last decade

ABSTRACT Despite advances in the characterization of developmental dyslexia (DD), several questions regarding the interplay between DD-susceptibility genes and environmental risk factors remain open. This systematic review aimed at answering the following questions: What has been the impact of new resources on the knowledge about DD? Which questions remain open? What is the investigative agenda for the short term? Forty-six studies were analyzed. Despite the growing literature on DD candidate genes, most studies have not been replicated. We found large effects on causative genes and smaller environmental contributions, involving maternal smoking during pregnancy, SES and the DYX1C1-1259C/G marker. Implications are discussed.