Miracle-dz/UniFAR-FTUs huggingface dataset:
Ambulatory Total Shoulder Arthroplasty: A Comprehensive Analysis of Current Trends, Complications, Readmissions, and Costs

Background: There have been few studies that have evaluated ambulatory total shoulder arthroplasty. The objectives of the present study were to investigate the current trends in ambulatory total shoulder arthroplasty in the United States; to characterize the rate of postoperative complications, hospital readmission, and risk factors associated with readmission; and to conduct a cost analysis comparing ambulatory total shoulder arthroplasty with matched inpatient total shoulder arthroplasty. Methods: A national insurance database was queried for patients who underwent anatomic total shoulder arthroplasty between the fourth quarter of 2010 and 2014. Patients undergoing ambulatory total shoulder arthroplasty and a matched group of patients undergoing inpatient total shoulder arthroplasty were identified. Complications were assessed for both groups. Risk factors for readmission within 90 days postoperatively were examined. The costs up to 30 days postoperatively were evaluated for patients who underwent ambulatory total shoulder arthroplasty and controls. Results: Included in the study were 706 patients who underwent ambulatory total shoulder arthroplasty. From the fourth quarter of 2010 to 2014, the yearly incidence of ambulatory total shoulder arthroplasty doubled. In the study, 4,459 patients who underwent inpatient total shoulder arthroplasty were matched to patients who underwent ambulatory total shoulder arthroplasty. In no instances were any complications present at a significantly higher rate in the patients who underwent ambulatory total shoulder arthroplasty. The rate of readmission was not significantly different (p > 0.05) between the 2 cohorts. The patients undergoing ambulatory total shoulder arthroplasty had significantly lower costs (p < 0.0001) at $14,722 compared with the matched controls at $18,336 in numerous itemized cost categories as well as costs related to diagnosis-related groups. Conclusions: In appropriately selected patients, ambulatory total shoulder arthroplasty is a viable and safe practice model. Ambulatory total shoulder arthroplasty also offers significant cost savings compared with inpatient total shoulder arthroplasty in matched patients. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
The clinical utility and diagnostic performance of MRI for identification and classification of knee osteochondritis dissecans.

BACKGROUND Magnetic resonance imaging (MRI) is a common clinical tool used to diagnose and monitor the progression and/or healing of osteochondritis dissecans of the knee. The purpose of this study was to systematically review the literature relative to the following questions: (1) Is MRI a valid, sensitive, specific, accurate, and reliable imaging modality to identify knee osteochondritis dissecans compared with arthroscopy? (2) Is MRI a sensitive tool that can be utilized to characterize lesion severity and stability of osteochondritis dissecans fragments in the knee? METHODS A systematic search was performed in December 2010 with use of PubMed MEDLINE (from 1966), CINAHL (from 1982), SPORTDiscus (from 1985), Scopus (from 1996), and EMBASE (from 1974) databases. RESULTS Seven studies, four Level-II and three Level-III investigations, met the specified inclusion criteria. No randomized controlled studies were identified. Because of inconsistencies between imaging techniques and methodological shortcomings of many of the studies, a meta-analysis was not performed. CONCLUSIONS The limited available evidence, methodological inconsistencies in imaging techniques, and lack of standardized grading criteria used in current studies prevent clear conclusions regarding the diagnostic and specific staging equivalency of MRI with arthroscopy. However, available evidence supports the use of MRI to detect the stability or instability of the lesion. Given the benefits of the use of MRI as a noninvasive tool to diagnose, predict lesion progression, and assess clinical outcomes of treatment, there is a pressing need for high-level, systematic, sound, and thorough studies related to the clinical utility of MRI for assessing osteochondritis dissecans of the knee.
Development of MBA Program-Service Quality Measurement Scale

The dimensions of perceived service quality are an important issue since it permits researchers to explore the relationships between each dimension and construct. This study developed perceived MBA program-service quality measurement scale (MBA-SQ) in MBA program. The targeted population of this study was MBA students from graduate school in Northern region Malaysia. A total of 222 questionnaires were collected out of the 331 questionnaires distributed. After conducted several testing the measurement instrument included a) unidimensionality of the constructs, b) construct validity, c) convergent validity, d) discriminant validity, and e) nomological validity. The results found that the MBA-SQ has success met research objective The MBA-SQ measurement can be used as a strategic tool for the marketing of the school’s programs. Perhaps then the graduate school of management would have the opportunity to fulfill needs and desires of students, giving the school a competitive advantage in the market.
Assessing Affective Factors to Improve Retention and Completion

Benjamin Bloom and four of his colleagues met over a period of years during the late 1940s and early 1950s as a group of educational psychologists seeking to create a framework of learning objectives as a basis for designing curricula, tests, and research. In 1956, they published Taxonomy of Educational Objectives – The Classification of Educational Goals – Handbook I: Cognitive Domain, which became one of the most significant books ever published in education. In 1973, several other psychologists, including Bloom, also published a book on the affective domain, though an effort explicating the psychomotor domain was never published. Their work initially focused on the cognitive domain, perhaps because many at the time believed it too difficult to define, let alone assess, the affective domain (Martin & Reigeluth, 1992). Over the next several decades, most educators would also focus here, as the cognitive domain served as the foundation for most of traditional education. In Bloom’s Taxonomy, the cognitive domain reflects knowledge, the psychomotor domain reflects skills, and the affective domain reflects attitudes.
Improved Upper Bounds for Planarization and Series-Parallelization of Degree-Bounded Graphs

We study the number of vertices which must be removed from a graph in order to make it planar or series-parallel. We give improved upper bounds on the number of vertices required to planarize graphs of bounded average degree $d$, and for small $d$ also an improved bound for series-parallelization. The coefficient of fragmentability of a class of graphs measures the proportion of vertices that need to be removed from the graphs in the class in order to leave behind bounded sized components. The above bounds on planarization yield improved bounds for the coefficient of fragmentability of the class of connected graphs of average degree at most $d$. As an application we give an improved bound on the size of regular expressions representing deterministic finite automata.
Imageries of family and nation: A comparative analysis of transnational adoption and care for unaccompanied minors in Belgium

Drawing on empirical research completed in Belgium, this article presents a comparative analysis of the care regimes for two categories of children: transnational adoptees and unaccompanied minors. Although state immigration policies consider the two groups of minors as humanitarian exceptions that require preferential treatment, the kind of humanitarian help and social investment they are believed to deserve differs dramatically. Ideologies of relational exclusivity and fixed belonging differently structure the investment of care that the two groups are believed to need, dependent on their ability to be read as freestanding, cultureless individuals, assimilable to the host nation.
Numerical approximations of one-dimensional linear conservation equations with discontinuous coefficients

Conservative linear equations arise in many areas of application, including continuum mechanics or high-frequency geometrical optics approximations. This kind of equations admits most of the time solutions which are only bounded measures in the space variable known as duality solutions. In this paper, we study the convergence of a class of finite-differences numerical schemes and introduce an appropriate concept of consistency with the continuous problem. Some basic examples including computational results are also supplied.
Expression of Reductive Dehalogenase Genes in Dehalococcoides ethenogenes Strain 195 Growing on Tetrachloroethene, Trichloroethene, or 2,3-Dichlorophenol

ABSTRACT Reductive dehalogenase (RD) gene transcript levels in Dehalococcoides ethenogenes strain 195 were investigated using reverse transcriptase quantitative PCR during growth and reductive dechlorination of tetrachloroethene (PCE), trichloroethene (TCE), or 2,3-dichlorophenol (2,3-DCP). Cells grown with PCE or TCE had high transcript levels (greater than that for rpoB) for tceA, which encodes the TCE RD, pceA, which encodes the PCE RD, and DET0162, which contains a predicted stop codon and is considered nonfunctional. In cells grown with 2,3-DCP, tceA mRNA was less than 1% of that for rpoB, indicating that its transcription was regulated. pceA and DET0162 were the only RD genes with high transcript levels in cells grown with 2,3-DCP. Proteomic analysis of PCE-grown cells detected both PceA and TceA with high peptide coverage but not DET0162, and analysis of 2,3-DCP-grown cells detected PceA with high coverage but not TceA, DET0162, or any other potential RD. Cells grown with PCE or 2,3-DCP were tested for the ability to dechlorinate PCE, TCE, or 2,3-DCP with H2 as the electron donor. 2,3-DCP-grown cells were unable to dechlorinate TCE but dechlorinated PCE to TCE without a lag, and PCE-grown cells dechlorinated 2,3-DCP without a lag. These results show that 2,3-DCP-grown cells do not produce TceA and that DET0162 is transcribed but its translation product is not detectable in cells and are consistent with PceA's being bifunctional, also serving as the 2,3-DCP RD. Chlorophenols naturally occur in soils and are good candidates for the original substrates for PceA.
Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study.

Recently, we demonstrated that cholesterol gallstone-prone C57L/J mice rarely develop gallstones unless they are infected with certain cholelithogenic enterohepatic Helicobacter species. Because the common gastric pathogen H. pylori has been identified in the hepatobiliary tree of cholesterol gallstone patients, we wanted to ascertain if H. pylori is cholelithogenic, by prospectively studying C57L infected mice fed a lithogenic diet. Weanling, Helicobacter spp. -free male C57L mice were either infected with H. pylori SS1 or sham dosed. Mice were then fed a lithogenic diet (1.0% cholesterol, 0.5% cholic acid, and 15% dairy triglycerides) for 8 wk. At 16 wk of age, mice were euthanatized, the biliary phenotype was analyzed microscopically, and tissues were analyzed histopathologically. H. pylori infection did not promote cholesterol monohydrate crystal formation (20% vs. 10%), sandy stone formation (0% for both), or true gallstone formation (20%) compared with uninfected mice fed the lithogenic diet (10%). Additionally, H. pylori failed to stimulate mucin gel accumulation in the gallbladder or alter gallbladder size compared with uninfected animals. H. pylori-infected C57L mice developed moderate to severe gastritis by 12 wk, and the lithogenic diet itself produced lesions in the forestomach, which were exacerbated by the infection. We conclude that H. pylori infection does not play any role in murine cholesterol gallstone formation. Nonetheless, the C57L mouse develops severe lesions of both the glandular and nonglandular stomach in response to H. pylori infection and the lithogenic diet, respectively.
The Effect of Everolimus Initiation and Calcineurin Inhibitor Elimination on Cardiac Allograft Vasculopathy in De Novo Recipients: One‐Year Results of a Scandinavian Randomized Trial

Early initiation of everolimus with calcineurin inhibitor therapy has been shown to reduce the progression of cardiac allograft vasculopathy (CAV) in de novo heart transplant recipients. The effect of de novo everolimus therapy and early total elimination of calcineurin inhibitor therapy has, however, not been investigated and is relevant given the morbidity and lack of efficacy of current protocols in preventing CAV. This 12‐month multicenter Scandinavian trial randomized 115 de novo heart transplant recipients to everolimus with complete calcineurin inhibitor elimination 7–11 weeks after HTx or standard cyclosporine immunosuppression. Ninety‐five (83%) patients had matched intravascular ultrasound examinations at baseline and 12 months. Mean (± SD) recipient age was 49.9 ± 13.1 years. The everolimus group (n = 47) demonstrated significantly reduced CAV progression as compared to the calcineurin inhibitor group (n = 48) (ΔMaximal Intimal Thickness 0.03 ± 0.06 and 0.08 ± 0.12 mm, ΔPercent Atheroma Volume 1.3 ± 2.3 and 4.2 ± 5.0%, ΔTotal Atheroma Volume 1.1 ± 19.2 mm3 and 13.8 ± 28.0 mm3 [all p‐values ≤ 0.01]). Everolimus patients also had a significantly greater decline in levels of soluble tumor necrosis factor receptor‐1 as compared to the calcineurin inhibitor group (p = 0.02). These preliminary results suggest that an everolimus‐based CNI‐free can potentially be considered in suitable de novo HTx recipients.
Parallel corpora for medium density languages

The choice of natural language technology appropriate for a given language is greatly impacted by density (availability of digitally stored material). More than half of the world speaks medium density languages, yet many of the methods appropriate for high or low density languages yield suboptimal results when applied to the medium density case. In this paper we describe a general methodology for rapidly collecting, building, and aligning parallel corpora for medium density languages, illustrating our main points on the case of Hungarian, Romanian, and Slovenian. We also describe and evaluate the hybrid sentence alignment method we are using.
Charting the Pathways of Lifelong Learning: A Longitudinal Perspective on Formal Study in Adulthood

This article explores the pattern of formal study activities over a period of 11 years for a group of adult learners. It is based on a two-phase study of students who enrolled in 1999 on courses run by the Faculty of Continuing Education at Birkbeck, University of London. Taking a longitudinal perspective, conducted retrospectively for 1994–1999, and prospectively for 2000–2005, it focuses on their study pathways and ‘progression’ over this period, exploring the patterns of participation, and whether these are associated with patterns of study motivations and outcomes. Using quantitative analysis of patterns of over this period, four ‘types' of students were identified: ‘ongoing students’; ‘intermittent students’; ‘resumers' and ‘one-off students’. Certain trends were discernable in terms of the demographic composition of each of these ‘types’, and in terms of study motivation and benefits. However, there was also considerable variability within each of the types, which highlights the extent of diversity among adult learners and the variety of roles played by education in the life course of individuals.
Effect of an Outreach Programme on Vandetanib Safety in Medullary Thyroid Cancer

Objectives: Effective management of adverse events (AEs) following vandetanib treatment is important to maximize clinical benefits. We examined whether more frequent contact with vandetanib-treated patients reduced AEs of CTCAE grade 2 or higher. Study Design: In this open-label, multicentre, phase III study, patients with locally advanced or metastatic medullary thyroid cancer were randomized to a patient outreach programme (outreach) or a standard AE monitoring schedule (vandetanib control) for 52 weeks. In addition to standard AE monitoring, patients in the outreach arm were contacted every 2 weeks by telephone/during their clinic visit for specific AE questioning related to diarrhoea, nausea, vomiting, fatigue, headache and rash. Patients received vandetanib at 200 or 300 mg/day, depending on the creatinine levels at screening. Results: Altogether, 205 patients were randomized (outreach, n = 103; vandetanib control, n = 102). This study did not meet its primary objective; the mean percentage of time patients experienced at least one AE of grade 2 or higher was higher for the outreach group (51.65%) than for the vandetanib control group (45.19%); the difference was not statistically significant (t statistic: 1.29; 95% CI -3.44 to 16.37%; p = 0.199). The most frequently reported AEs were diarrhoea (56.9% for the outreach group vs. 46.6% for the vandetanib controls), hypertension (36.3 vs. 31.1%), rash (25.5 vs. 24.3%) and nausea (25.5% vs. 18.4%), and the most frequently reported AEs of grade 2 or higher were hypertension (33.3 vs. 23.3%), diarrhoea (26.5 vs. 24.3%) and dermatitis acneiform (11.8 vs. 9.7%). Conclusions: Additional outreach to patients treated with vandetanib had no impact on the rate or severity of AEs compared to the standard AE monitoring schedule. AEs were consistent with the known safety profile of vandetanib.
Molecular genetic methods in the diagnosis of lower respiratory tract infections

Molecular diagnostic techniques, such as PCR, have become useful tools for the rapid etiological diagnosis of lower respiratory tract infections. Nucleic acid amplification tests (NAATs) have been evaluated for detecting most respiratory pathogens, and commercial assays are available for some pathogens. However, standardized protocols are needed before these assays are introduced into routine diagnostic use. For pneumonia, NAATs offer advantages over conventional tests for the detection of Mycoplasma pneumoniae, Legionella spp. and Chlamydia pneumoniae. For pneumococcal pneumonia in adults, PCR adds little to existing diagnostic tests, and is unable to distinguish pneumococcal colonization from infection when testing respiratory samples. Although less sensitive than culture‐based methods, several commercial molecular diagnostic assays have been developed for tuberculosis and are useful rapid tests for selected patients. PCR can now be considered the rapid diagnostic test of choice for pertussis and some respiratory virus infections. Further work is required to better characterize the role of molecular diagnostic tests for diagnosing lower respiratory tract infections, and to develop standard assays that can be readily adopted by routine diagnostic laboratories.
Identification and discrimination of voicing and place-of-articulation in developmental dyslexia

Problems in reading and spelling may arise from poor perception of speech sounds. To study the integrity of phonological access in children with developmental dyslexia (mean age 8 years, 9 months) as compared to two control groups of children (age-matched and matched on reading level), identification and discrimination functions of the features voicing and place-of-articulation were assessed. No differences were found between groups with respect to identification of place-of-articulation. With respect to identification of the voicing contrast, children with developmental dyslexia performed poorer than age-matched controls, but similar to reading-level controls. For the voicing as well as the place-of-articulation contrast, children with developmental dyslexia discriminated poorer than both control groups. This pattern of identification and discrimination performance is discussed relative to the multidimensionality of the speech perception system. The clinical relevance of these perception tasks could be d.
Neuroendocrine Cells in Barrett’s Mucosa and Adenocarcinomas of the Gastroesophageal Junction

We estimated the prevalence and prognostic significance of neuroendocrine (NE) cells in a series of 208 resection specimens containing gastroesophageal junction (GEJ) adenocarcinomas, with 56 specimens containing Barrett’s mucosa. Immunohistochemically, chromogranin A (CGA) was positive in 49% (102/208) of GEJ adenocarcinomas and in 68% (38/56) of Barrett’s mucosas. CGA in GEJ tumors correlated with pTNM stage. CGA in Barrett correlated with pTNM stage and tumor grade of the adjacent carcinoma. Patients with CGA in Barrett had better survival than patients without CGA in Barrett, with 5-year survival percentages of 56% and 9%, respectively. In multivariate analysis, CGA in Barrett was an independent prognostic factor for survival after surgery. Therefore CGA in Barrett adjacent to GEJ adenocarcinoma might be helpful in the assessment of patient outcome.
A Tagless Indoor Localization System Based on Capacitive Sensing Technology

Accurate indoor person localization is essential for several services, such as assisted living. We introduce a tagless indoor person localization system based on capacitive sensing and localization algorithms that can determine the location with less than 0.2 m average error in a 3 m × 3 m room and has recall and precision better than 70%. We also discuss the effects of various noise types on the measurements and ways to reduce them using filters suitable for on-sensor implementation to lower communication energy consumption. We also compare the performance of several standard localization algorithms in terms of localization error, recall, precision, and accuracy of detection of the movement trajectory.
UvA-DARE ( Digital Academic Repository ) Ba 2 + replaces Ca 2 + / calmodulin in the activation of protein phosphates and in exocytosis of all major transmitters Verhage

Exocytosis from nerve terminals is triggered by depolarization-evoked Ca*+ entry, which also activates calmodulin and stimulates protein phosphorylation. Ba2+ is believed to replace Ca2+ m triggering exocytosis without activation of calmodulin and can therefore be ‘+ used to unravel aspects of presynaptic function. We have analysed the cellular actions of Ba in relation to its effect on transmitter release from isolated nerve terminals. Barium evoked specific release of amino acid transmitters, catecholamines and neuropeptides (EC,, 0.2-0.5 mM), similar to K’/Ca” -evoked release both in extent and kinetics. Ba2 +and Ca2+ -evoked release were not additive. In contrast to Ca’+, Ba2+ triggered release which was insensitive to trifluoperizine and hardly stimulated protein phosphorylation. These observations are in accordance with the ability of Ba2+ to replace CaZf m exocytosis without activating calmodulin. Nevertheless, calmodulin appears to be essential for regular (Cazf -triggered) exocytosis, given its sensitivity to trifluoperizine. Both Ba2+and Ca’+-evoked release were blocked by okadaic acid. Furthermore, anti-calcineurin antibodies decreased Ba’+-evoked release. In conclusion, BaZf replaces Ca’+/calmodulin in the release of the same transmitter pool. Calmodulin-dependent phosphorylation appears not to be essential for transmitter release. Instead, our data implicate both CaZf -dependent and -independent dephosphorylation in the events prior to neurotransmitter exocytosis.