Miracle-dz/UniFAR-FTUs huggingface dataset:
DBSR: Dynamic Base Station Repositioning Using Genetic Algorithm in Wireless Sensor Network

Wireless sensor networks (WSNs) are commonly used in various ubiquitous and pervasive applications. Due to limited power resources, the optimal dynamic base station (BS) replacement could be Prolong the sensor network lifetime. In this paper we’ll present a dynamic optimum method for base station replacement so that can save energy in sensors and increases network lifetime. Because positioning problem is a NP-hard problem [1], therefore we’ll use genetic algorithm to solve positioning problem. We’ve considered energy and distance parameters for finding BS optimized position. In our represented algorithm base station position is fixed just during each round and its positioning is done at the start of next round then it’ll be placed in optimized position. Evaluating our proposed algorithm, we’ll execute DBSR algorithm on LEACH & HEED Protocols.
Melatonin improves the meiotic maturation of porcine oocytes by reducing endoplasmic reticulum stress during in vitro maturation

Under endoplasmic reticulum (ER)‐stress conditions, the unfolded protein response (UPR) generates a defense mechanism in mammalian cells. The regulation of UPR signaling is important in oocyte maturation, embryo development, and female reproduction of pigs. Recent studies have shown that melatonin plays an important role as an antioxidant to improve pig oocyte maturation. However, there is no report on the role of melatonin in the regulation of UPR signaling and ER‐stress during in vitro maturation (IVM) of porcine oocytes. Therefore, the objective of this study was to investigate the antioxidative effects of melatonin on porcine oocyte maturation through the regulation of ER‐stress and UPR signaling. We investigated the changes in the mRNA/protein expression levels of three UPR signal genes (Bip/Grp78, ATF4, P90/50ATF6, sXbp1, and CHOP) on oocytes, cumulus cells, and cumulus‐oocyte complexes (COCs) during IVM (metaphase I; 22 hours and metaphase II; 44 hours) by Western blot and reverse transcription‐polymerase chain reaction analysis. Treatment with the ER‐stress inducer, tunicamycin (Tm), significantly increased expression of UPR markers. Additionally, cumulus cell expansion and meiotic maturation of oocytes were reduced in COCs of Tm‐treated groups (1, 5, and 10 μg/mL). We confirmed the reducing effects of melatonin (0.1 μmol/L) on ER‐stress after pretreatment with Tm (5 μg/mL; 22 hours) in maturing COCs. Addition of melatonin (0.1 μmol/L) to Tm‐pretreated COCs recovered meiotic maturation rates and expression of most UPR markers. In conclusion, we confirmed a role for melatonin in the modulation of UPR signal pathways and reducing ER‐stress during IVM of porcine oocytes.
Effects of Quetiapine on Platelets in Major Depression

1.1 Objectives: Test the prevailing hypothesis that depressive illness is associated with platelet hyperactivity and that treatment with an atypical antipsychotic with established antidepressant efficacy – quetiapine - will normalize platelet activity. 1.2 Methods: Forty-seven outpatients with major depressive disorder (MDD) and 27 healthy controls (HC) without evidence of cardiovascular disease were enrolled. Behavioral rating scales and medical tests preceded baseline assessments of (1) platelet-rich plasma (PRP) aggregometry and (2) whole blood flow cytometry (P-selectin surface labeling). The measures were repeated in those MDD subjects who completed 8 weeks (n=27) or 12 weeks (n=19) of treatment with quetiapine. 1.3 Results: Untreated MDD compared to HC subjects displayed more platelet aggregation when PRP was stirred agonist-free (p=0.021). Other platelet measurements at baseline such as in vitro agonist-stimulated PRP aggregometry or P-selectin expression by flow cytometry did not distinguish MDD from HC subjects. After 8 weeks on quetiapine, a reduced (now normal) agonist-free aggregatory response to stirring (p=0.035) was observed. By 12 weeks the aggregometry response to arachidonic acid (AA) was also lowered (p=0.016 vs. pretreatment; p=0.001 vs. HC). Other agonist additions (ADP, epinephrine, or collagen) failed to distinguish MDD from HC. There were no significant associations between mood rating scores and any form of platelet activity at any time point on quetiapine. 1.4 Limitations: High percentage of dropouts attributable to dose-related side effects limited the post-treatment assessments. 1.5 Conclusions: The hypothesis that untreated depression is associated with more active platelets, was confirmed, but this finding was confined to the “resting”, or agonist-free state. Quetiapine treatment normalized this resting activity and led to a lower-than-normal response to AA-induced aggregation after 12 weeks of treatment. These findings confirm that 8 weeks treatment with quetiapine can normalize at least one form of platelet hyperactivity, but the lower-than-healthy response to AA after 12 weeks on quetiapine warrants further study.
Alveolar Ridge Splitting Versus Autogenous Onlay Bone Grafting: Complications and Implant Survival Rates

Purpose: To compare the complications and implant survival rates of localized alveolar ridge deficiencies in the horizontal dimension reconstructed by alveolar ridge splitting (ARS) or autogenous onlay bone grafting (OBG). Materials and Methods: Twenty-eight ARS and 28 OBG were performed. The survival rate of the all included implants was evaluated using the clinical and radiographical evaluation criteria of Misch et al. Temporary exposure of graft, mild infection, temporary paresthesia, and bad split were defined as minor complications; permanent exposure of graft, loss of graft, and permanent paresthesia were defined as major complications. Major and minor complications of ARS and OBG groups were statistically compared. Results: When the minor and major complication rates are considered, there was not any statistically significant difference between OBG (P = 0.099) and ARS (P = 0.241) groups. The satisfactory survival rate of OBG group was 92% and was 100% in the ARS group, and the difference was not statistically significant (P = 0.116). Conclusion: When reconstructing vertically sufficient but horizontally insufficient alveolar ridges, ridge splitting technique could shorten the treatment period, decrease postoperative swelling and pain, eliminate the need for a second surgical site, reduce the treatment cost, and ease the patient cooperation to the surgery.
Positional goods and the social rank hypothesis: Income inequality affects online chatter about high- and low-status brands on twitter

According to a social rank hypothesis, consumers who live in regions with higher income inequality will show greater interest in, and attention towards, positional goods and high-status brands that serve a social signaling role. We analyze millions of posts on the microblogging platform Twitter for mentions of high and low status brands. We find that luxury brands such as “Louis Vuitton” and “Rolex” are more frequently mentioned in tweets originating from U.S. states, counties and major metropolitan areas with higher levels of income inequality. In contrast, mentions of everyday brands such as “Walmart” or “Kmart” are more frequent in regions with a more equal distribution of income. Using sentiment analysis, we find higher valence (positivity) and arousal (excitement) for tweets that both mention high status brands and originate from regions with high levels of income inequality. These results corroborate the social rank hypothesis, showing that more psychological resources are allocated to positional consumption when the income gap between the rich and the poor is larger.
RNA-Seq Reveals an Integrated Immune Response in Nucleated Erythrocytes

Background Throughout the primary literature and within textbooks, the erythrocyte has been tacitly accepted to have maintained a unique physiological role; namely gas transport and exchange. In non-mammalian vertebrates, nucleated erythrocytes are present in circulation throughout the life cycle and a fragmented series of observations in mammals support a potential role in non-respiratory biological processes. We hypothesised that nucleated erythrocytes could actively participate via ligand-induced transcriptional re-programming in the immune response. Methodology/Principal Findings Nucleated erythrocytes from both fish and birds express and regulate specific pattern recognition receptor (PRR) mRNAs and, thus, are capable of specific pathogen associated molecular pattern (PAMP) detection that is central to the innate immune response. In vitro challenge with diverse PAMPs led to de novo specific mRNA synthesis of both receptors and response factors including interferon-alpha (IFNα) that exhibit a stimulus-specific polysomal shift supporting active translation. RNA-Seq analysis of the PAMP (Poly (I∶C), polyinosinic∶polycytidylic acid)-erythrocyte response uncovered diverse cohorts of differentially expressed mRNA transcripts related to multiple physiological systems including the endocrine, reproductive and immune. Moreover, erythrocyte-derived conditioned mediums induced a type-1 interferon response in macrophages thus supporting an integrative role for the erythrocytes in the immune response. Conclusions/Significance We demonstrate that nucleated erythrocytes in non-mammalian vertebrates spanning significant phylogenetic distance participate in the immune response. RNA-Seq studies highlight a mRNA repertoire that suggests a previously unrecognized integrative role for the erythrocytes in other physiological systems.
Predator-induced phenotypic plasticity of shape and behavior: parallel and unique patterns across sexes and species

Abstract Phenotypic plasticity is often an adaptation of organisms to cope with temporally or spatially heterogenous landscapes. Like other adaptations, one would predict that different species, populations, or sexes might thus show some degree of parallel evolution of plasticity, in the form of parallel reaction norms, when exposed to analogous environmental gradients. Indeed, one might even expect parallelism of plasticity to repeatedly evolve in multiple traits responding to the same gradient, resulting in integrated parallelism of plasticity. In this study, we experimentally tested for parallel patterns of predator-mediated plasticity of size, shape, and behavior of 2 species and sexes of mosquitofish. Examination of behavioral trials indicated that the 2 species showed unique patterns of behavioral plasticity, whereas the 2 sexes in each species showed parallel responses. Fish shape showed parallel patterns of plasticity for both sexes and species, albeit males showed evidence of unique plasticity related to reproductive anatomy. Moreover, patterns of shape plasticity due to predator exposure were broadly parallel to what has been depicted for predator-mediated population divergence in other studies (slender bodies, expanded caudal regions, ventrally located eyes, and reduced male gonopodia). We did not find evidence of phenotypic plasticity in fish size for either species or sex. Hence, our findings support broadly integrated parallelism of plasticity for sexes within species and less integrated parallelism for species. We interpret these findings with respect to their potential broader implications for the interacting roles of adaptation and constraint in the evolutionary origins of parallelism of plasticity in general.
In-cloud sulfate addition to single particles resolved with sulfur isotope analysis during HCCT-2010

Abstract. In-cloud production of sulfate modifies aerosol size distribution, with important implications for the magnitude of indirect and direct aerosol cooling and the impact of SO2 emissions on the environment. We investigate which sulfate sources dominate the in-cloud addition of sulfate to different particle classes as an air parcel passes through an orographic cloud. Sulfate aerosol, SO2 and H2SO4 were collected upwind, in-cloud and downwind of an orographic cloud for three cloud measurement events during the Hill Cap Cloud Thuringia campaign in autumn 2010 (HCCT-2010). Combined SEM and NanoSIMS analysis of single particles allowed the δ34S of particulate sulfate to be resolved for particle size and type. The most important in-cloud SO2 oxidation pathway at HCCT-2010 was aqueous oxidation catalysed by transition metal ions (TMI catalysis), which was shown with single particle isotope analyses to occur primarily in cloud droplets nucleated on coarse mineral dust. In contrast, direct uptake of H2SO4 (g) and ultrafine particulate were the most important sources modifying fine mineral dust, increasing its hygroscopicity and facilitating activation. Sulfate addition to "mixed" particles (secondary organic and inorganic aerosol) and coated soot was dominated by in-cloud aqueous SO2 oxidation by H2O2 and direct uptake of H2SO4 (g) and ultrafine particle sulfate, depending on particle size mode and time of day. These results provide new insight into in-cloud sulfate production mechanisms, and show the importance of single particle measurements and models to accurately assess the environmental effects of cloud processing.
Predicting 1-year mortality after hospitalization for community-acquired pneumonia

Background Community-acquired pneumonia (CAP) is a major public health problem with high short- and long-term mortality. The main aim of this study was to develop and validate a specific prognostic index for one-year mortality in patients admitted for CAP. Methods This was an observational, prospective study of adults aged ≥18 years admitted to Galdakao-Usansolo Hospital (Bizkaia, Spain) from January 2001 to July 2009 with a diagnosis of CAP surviving the first 15 days. The entire cohort was divided into two parts, in order to develop a one-year mortality predictive model in the derivation cohort, before validation using the second cohort. Results A total of 2351 patients were included and divided into a derivation and a validation cohort. After deaths within 15 days were excluded, one-year mortality was 10.63%. A predictive model was created in order to predict one-year mortality, with a weighted score that included: aged over 80 years (4 points), congestive heart failure (2 points), dementia (6 points), respiratory rate ≥30 breaths per minute (2 points) and blood urea nitrogen >30 mg/dL (3 points) as predictors of higher risk with C-index of 0.76. This new model showed better predictive ability than current risk scores, PSI, CURB65 and SCAP with C-index of 0.73, 0.69 and 0.70, respectively. Conclusions An easy-to-use score, called the one-year CAPSI, may be useful for identifying patients with a high probability of dying after an episode of CAP.
Emotional Coping Differences Among Breast Cancer Patients From an Online Support Group: A Cross-Sectional Study

Background Due to mixed findings in research on the effect of online peer-to-peer support on psychological well-being, there is a need for studies explaining why and when online support communities are beneficial for cancer patients. Objective Previous studies have typically not taken into account individual coping differences, despite the fact that patients have different strategies to cope with cancer-related emotions. In the current study, it was predicted that the effects of online support group participation would partly depend on patients’ ability to cope with thoughts and emotions regarding the illness. Methods For this study, 184 Dutch breast cancer patients filled out a questionnaire assessing activity within a peer-led online support community, coping with emotions and thoughts regarding the illness (cognitive avoidance, emotional processing, and expression) and psychological well-being (depression, breast cancer-related concerns, and emotional well-being). Of these, 163 patients were visiting an online peer-led support community. Results Results showed interactions of the intensity of support group participation and coping style on psychological well-being. Specifically, we found an interaction of online activity and emotional expression on depression (beta=–.17, P=.030), a marginally significant interaction of online activity and emotional expression on emotional well-being (beta=.14, P=.089), and an interaction of online activity and cognitive avoidance on breast cancer–related concerns (beta=.15, P=.027). For patients who actively dealt with their emotions and thoughts, active online support group participation was positively related to psychological well-being. For patients high on avoidance of illness-related thoughts or low on emotional expression, active participation was negatively related to measures of well-being. Conclusions The current study revealed the role of individual differences in coping in online support group participation. Results suggest that breast cancer patients’ ability to cope with emotions and thoughts regarding the illness influence the relationship between online support group participation and psychological well-being.
The Humanizing Voice: Speech Reveals, and Text Conceals, a More Thoughtful Mind in the Midst of Disagreement

A person’s speech communicates his or her thoughts and feelings. We predicted that beyond conveying the contents of a person’s mind, a person’s speech also conveys mental capacity, such that hearing a person explain his or her beliefs makes the person seem more mentally capable—and therefore seem to possess more uniquely human mental traits—than reading the same content. We expected this effect to emerge when people are perceived as relatively mindless, such as when they disagree with the evaluator’s own beliefs. Three experiments involving polarizing attitudinal issues and political opinions supported these hypotheses. A fourth experiment identified paralinguistic cues in the human voice that convey basic mental capacities. These results suggest that the medium through which people communicate may systematically influence the impressions they form of each other. The tendency to denigrate the minds of the opposition may be tempered by giving them, quite literally, a voice.
Fluid motion and solute distribution around sinking aggregates. I. Small-scale fluxes and heterogeneity of nutrients in the pelagic environment

Marine snow aggregates are sites of elevated biological activity. This activity depends on the exchange of solutes (O2, CO2, mineral nutrients, dissolved organic material, etc.) between the aggregate and the environment and causes heterogeneity in the distribution of dissolved substances in the ambient water. We described the fluid flow and solute distribution around a sinking aggregate by solving the Navier-Stokes' equations and the advection-diffusion equations numerically. The model is valid for Reynolds numbers characteristic of marine snow, up to Re = 20. The model demon- strates the importance of a correct flow environment when making biological rate-measurements on aggregates (e.g., oxygen consumption/production, growth rates of bacteria and phytoplankton) because both solute fluxes and internal solute concentrations depend strongly on the flow environ- ment. Observations of flow and oxygen-concentration fields in the vicinity of both artificial and natural oxygen-consuming aggregates that are suspended in a flow compare well with model predictions, thus suggesting that our set-up is suitable for making biological rate measurements. The sinking aggregate leaves a long slender plume in its wake, where solute concentration is either elevated (leaking substances) or depressed (consumed substances) relative to ambient concentration. Such plumes may impact the nutrition of osmotrophs. For example, based on published solubilization rates of aggregates we describe the amino acid plume behind a sinking aggregate (0.1 to 1.0 cm radius). The volume of the plume with amino acid concentrations high enough to significantly affect bacterial uptake rates is ca 100 〈 the volume of the aggregate itself. Thus, sinking aggregates may create significant microniches also for free-living bacteria.
Seasonal Variation in Thermoregulatory Behavior and Body Temperature of Diurnal Kalahari Lizards

We discuss seasonal variation in thermoregulatory behavior and its consequences on body temperature for 12 species of diurnal lizards in the southern Kalahari semidesert of Africa and also evaluate several methods of attempting to document thermoregulatory behavior using a descrip- tive data base. Lizards vary time of activity among seasons, which limits the variation in ambient conditions actually experienced. Ground-dwelling lizards and probably arboreal lizards move nonrandomly with respect to sun and shade; thus the percentage of lizards in sun is inversely proportional to air tempera- ture. Arboreal lizards shift to higher perches at midday in summer and to logs or ground in winter thus decreasing and increasing incident heat loads, respectively. Both juveniles and adults of 3 species, only juveniles of 2 species, and only adults in I species are active in winter: both adults and juveniles of 6 species brumate (= hibernate). Mean body temperature (Tb) varies within days and among months and is positively correlated with corresponding mean air temperature (Ta) in almost all species. Nonetheless, correlation and regression analysis suggests that thermoregulatory behaviors reduce the impact of variations in ambient condi- tions on Kalahari lizards. The mean Tb of different species reflect evolutionary relationships. In summer, mean Tb is propor- tional to the percentage of lizards in sun and with the tendency of lizards to be active only in summer. Thus, lizards with inferred low optimal temperatures are active during more months of the year.
Neural decoding of attentional selection in multi-speaker environments without access to clean sources

Objective. People who suffer from hearing impairments can find it difficult to follow a conversation in a multi-speaker environment. Current hearing aids can suppress background noise; however, there is little that can be done to help a user attend to a single conversation amongst many without knowing which speaker the user is attending to. Cognitively controlled hearing aids that use auditory attention decoding (AAD) methods are the next step in offering help. Translating the successes in AAD research to real-world applications poses a number of challenges, including the lack of access to the clean sound sources in the environment with which to compare with the neural signals. We propose a novel framework that combines single-channel speech separation algorithms with AAD. Approach. We present an end-to-end system that (1) receives a single audio channel containing a mixture of speakers that is heard by a listener along with the listener’s neural signals, (2) automatically separates the individual speakers in the mixture, (3) determines the attended speaker, and (4) amplifies the attended speaker’s voice to assist the listener. Main results. Using invasive electrophysiology recordings, we identified the regions of the auditory cortex that contribute to AAD. Given appropriate electrode locations, our system is able to decode the attention of subjects and amplify the attended speaker using only the mixed audio. Our quality assessment of the modified audio demonstrates a significant improvement in both subjective and objective speech quality measures. Significance. Our novel framework for AAD bridges the gap between the most recent advancements in speech processing technologies and speech prosthesis research and moves us closer to the development of cognitively controlled hearable devices for the hearing impaired.