Miracle-dz/UniFAR-FTUs huggingface dataset:
Liver Carcinogenesis is Not a Predicted Outcome of Chemically Induced Hepatocyte Proliferation

Cell proliferation has long been recognized as a basic component of multistage carcinogenesis. Based largely on the finding that certain nongenoloxic chemical carcinogens induce cell proliferation in the same organ that develops tumors after long-term exposure, some suggest that the increased rates of cell division account for the carcinogenicity of these chemicals. This paper examines relationships between chemically induced liver toxicity, cell proliferation, and liver carcinogenesis; major factors include consistency, transient vs. sustained dose-response correspondence, and scientific plausibility. For a presumed mechanism to be valid, a sustained proliferative response is critical, largely because transient increases in hepatocyte proliferation are not sufficient to induce cancer or promote liver tumor development. A consistent association between liver toxicity and carcinogenicity has not been established. Our evaluation of studies on purported relationships between chemically induced cell proliferation and liver carcinogenesis shows: 1) that inconsistencies in sex and species specificity exist, 2) that a large percentage of proliferative responses are transient, 3) that inconsistencies in response to various hepatic peroxisome proliferators are common, and 4) that dose-response and duration relationships have not been sufficiently examined. Studies of proliferative responses of putative preneoplastic cells in the liver indicate that these cells divide faster than normal hepatocytes and also have higher death rates. Chemicals that induce cell proliferation in preneoplastic foci do not always provide a persistent increase in replication rates, even with continuous exposure. A selective growth advantage to preneoplastic cells in the liver may be provided either by an enhancement of the replication rates of these cells compared to the surrounding normal hepatocytes, by inhibition of cell loss, or by inhibition of the growth rate of normal cells. More work is needed to understand how chenvcal carcinogens and noncarcinogens affect cell division and cell loss of normal hepatocytes and of preneoplastic cells; measurements of hepatocyte proliferation alone are not sufficient to elucidate mechanisms of liver tumor development or to predict liver carcinogenesis. Because of our limited knowledge of the complex molecular changes occurring during liver cancer, it would be inappropriate and far too premature to amend scientific risk assessment procedures for nongenotoxic chemical carcinogens based on oversimplified or incompletely tested speculations.
Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial K(ATP) channels in mouse cardiomyocytes.

Potassium (K+) channels in the inner mitochondrial membrane influence cell function and survival. Increasing evidence indicates that multiple signaling pathways and pharmacological actions converge on mitochondrial ATP-sensitive K+ (mitoKATP) channels and PKC to confer cytoprotection against necrotic and apoptotic cell injury. However, the molecular structure of mitoKATP channels remains unresolved, and the mitochondrial phosphoprotein(s) that mediate cytoprotection by PKC remain to be determined. As mice deficient in the main sarcolemmal gap junction protein connexin 43 (Cx43) lack this cytoprotection, we set out to investigate a possible link among mitochondrial Cx43, mitoKATP channel function, and PKC activation. By patch-clamping the inner membrane of subsarcolemmal murine cardiac mitochondria, we found that genetic Cx43 deficiency, pharmacological connexin inhibition by carbenoxolone, and Cx43 blockade by the mimetic peptide 43GAP27 each substantially reduced diazoxide-mediated stimulation of mitoKATP channels. Suppression of mitochondrial Cx43 inhibited mitoKATP channel activation by PKC. MitoKATP channels of interfibrillar mitochondria, which do not contain any detectable Cx43, were insensitive to both PKC activation and diazoxide, further demonstrating the role of Cx43 in mitoKATP channel stimulation and the compartmentation of mitochondria in cell signaling. Our results define a role for mitochondrial Cx43 in protecting cardiac cells from death and provide a link between cytoprotective stimuli and mitoKATP channel opening, making Cx43 an attractive therapeutic target for protection against cell injury.
Role Conflict and Role Ambiguity: Integration of the Literature and Directions for Future Research

Although research on role conflict and ambiguity has been extensive, there has been only moderate consistency in the focus and results of the research, while several areas of role conflict and ambiguity research are still relatively unexamined. This paper suggests that a framework for organizing the recent research may assist in consolidating the field and providing an understanding of where we are, what is left to be done and, therefore, direction for future role conflict and ambiguity research.
The Role of the Department Head or Chairman: Discipline, Sex and Nationality as Factors Influencing Faculty Opinion

The influence of academic discipline, sex and nationality upon one's definiton of the role of the head or chairman of a university department was studied by means of a question- naire administered to members of the Faculty of Arts and Science of the University of Victoria. Discipline was found to be of overriding importance. Social scientists, unlike either Natural Scientists or Humanists, rejected leadership while favouring the roles of coordinator and, to a lesser degree, of representative. Women in the Humanities and Natural Sciences were more likely to expect leadership than were their male colleagues. The nationality of the respondents, however, did not appear to influence their expectations of the department head or chairman.
Task-technology Fit Aware Expectation-confirmation Model towards Understanding of MOOCs Continued Usage Intention

Massive Open Online Courses (MOOCs) have been playing a pivotal role among the latest e-learning ini-tiative and obtain widespread popularity in many uni-versities. But the low course completion rate and the high midway dropout rate of students have puzzled some researchers and designers of MOOCs. Therefore, it is important to exp lore the factors affecting students’ continuance intention to use MOOCs. This study integrates task-technology fit which can explain how the characteristics of task and technology affect the outcome of technology utilization into expectation-confirmation model to analyze the factors influencing students’ keeping using MOOCs and the relationships of constructs in the model, then it will also extend our understandings of continuance intention about MOOCs. We analyze and study 234 respondents, and results reveal that perceived usefulness, satisfaction and task-technology fit are important precedents of the intention to continue using MOOCs. Researchers and designers of MOOCs may obtain further insight in continuance intention about MOOCs.
Clustering and the spatial distribution of organic farming in England and Wales

Previous geographical research on organic farming suggests a process of aggregation at the regional scale and spatial clustering at the local level, the latter in response to a neighbourhood effect and different socio-cultural factors. However, little research has been conducted on the geographical distribution of organic farming in a UK context. Using both secondary and primary data, this paper examines geographical aspects of organic farming in England and Wales. At a regional scale, three major concentrations of organic production are found to the south and west of a line drawn between Bangor in north Wales and Brighton in south-east England (the Brighton-Bangor line). One of these concentrations occurs in the counties of East and West Sussex in south-east England. Yet, within these two counties the pattern of organic farming is quite random and there is little evidence of spatial clustering, a neighbourhood effect or the influence of socio-cultural factors. Instead, many of the farms have converted from conventional farming since 1990 and are driven by a strong economic imperative, which encourages the use of national as well as local outlets to both sell their produce and purchase necessary inputs. © 2010 The Authors. Area © 2010 Royal Geographical Society (with the Institute of British Geographers).
The Effect of Portfolio and Self Assessment on Writing Ability and Autonomy

This study explored the effect of portfolio and self assessment on writing tasks on the one hand and self regulation ability on the other by assigning sixty freshman undergraduate university students majoring in teaching English as a foreign language to a control and experimental group. They had enrolled in the Writing Essay course at Tabaran University in Iran in 2010. While both groups wrote several essays during the course and took a self regulation questionnaire and the same writing task at the beginning and end of the course as pre-and-post tests, only the participants in the experimental group were required to write portfolios regularly and perform self assessment tasks. The multivariate analysis of results showed that the two groups had no significant difference in their writing and self-regulation abilities when the course started. The experimental group, however, did not only score significantly higher than the control group on the writing task (F = 14.390, df = 1, p <.000) but also gained higher self regulation ability as a result of writing portfolios and self assessment (F = 58.235, df = 1, p <.000). The implications of the study are discussed within a foreign language teaching context.
Lawrence Berkeley National Laboratory Lawrence Berkeley National Laboratory Title Superconducting materials for large scale applications

Since the 1960’s, Nb-Ti (superconducting transition temperature Tc = 9K) and Nb3Sn (Tc = 18K) have been the materials of choice for virtually all superconducting magnets. However, the prospects for the future changed dramatically in 1987 with the discovery of layered cuprate superconductors with Tc values that now extend up to about 135 K. Fabrication of useful conductors out of the cuprates has been difficult, but a first generation of silver-sheathed composite conductors based on (Bi,Pb)2Sr2Ca2Cu3O10 (Tc ~ 110K) has already been commercialized. Recent progress on a second generation of biaxially aligned coated conductors using the less anisotropic YBa2Cu3O7 structure has been rapid, suggesting that it too might enter service in the near future. The discovery of superconductivity in MgB2 below 39 K in 2001 has brought yet another candidate material to the large-scale applications mix. Two distinct markets for superconductor wires exist – the more classical low-temperature magnet applications such as particle accelerators, NMR and MRI magnets, and plasma-containment magnets for fusion power, and the newer and potentially much larger market for electric power equipment, such as motors, generators, synchronous condensers, power transmission cables, transformers and fault current limiters for the electric utility grid. We review key properties and recent progress in these materials and assess their prospects for further development and application.
Self-Criticism, Anxious Attachment, and Avoidant Attachment as Predictors of Career Decision Making

This study examined a model in which the anxious and the avoidant forms of insecure attachment were related to career indecision through the mediation of self-criticism. One hundred seventy-three college students completed questionnaires measuring anxious and avoidant dimensions of insecure attachment, self-criticism, and career indecision. Path analysis indicated that avoidant attachment was indirectly related to career indecision through the full mediation of self-criticism and that the linkage between anxious attachment and career indecision was partially mediated by self-criticism. These findings advance the understanding of how internalized relationships with significant others may impact career planning and development, suggesting distinct mechanisms by which the anxious and the avoidant forms of insecure attachment may exacerbate career decision making. In addition, the findings highlight the centrality of self-criticism in the process of career decision making. Implications for the career decision-making process and career planning are suggested, and recommendations for career counseling interventions are presented.
Satellite-derived variability in chlorophyll, wind stress, sea surface height, and temperature in the northern California Current System

[1] Satellite-derived data provide the temporal means and seasonal and nonseasonal variability of four physical and biological parameters off Oregon and Washington (41°-48.5°N). Eight years of data (1998-2005) are available for surface chlorophyll concentrations, sea surface temperature (SST), and sea surface height, while six years of data (2000-2005) are available for surface wind stress. Strong cross-shelf and alongshore variability is apparent in the temporal mean and seasonal climatology of all four variables. Two latitudinal regions are identified and separated at 44°-46°N, where the coastal ocean experiences a change in the direction of the mean alongshore wind stress, is influenced by topographic features, and has differing exposure to the Columbia River Plume. All these factors may play a part in defining the distinct regimes in the northern and southern regions. Nonseasonal signals account for ∼60-75% of the dynamical variables. An empirical orthogonal function analysis shows stronger intra-annual variability for alongshore wind, coastal SST, and surface chlorophyll, with stronger interannual variability for surface height. Interannual variability can be caused by distant forcing from equatorial and basin-scale changes in circulation, or by more localized changes in regional winds, all of which can be found in the time series. Correlations are mostly as expected for upwelling systems on intra-annual timescales. Correlations of the interannual timescales are complicated by residual quasi-annual signals created by changes in the timing and strength of the seasonal cycles. Examination of the interannual time series, however, provides a convincing picture of the covariability of chlorophyll, surface temperature, and surface height, with some evidence of regional wind forcing.
Neuroimaging: a new training issue in psychiatry?

Many studies recently have highlighted the role of neuroimaging in the diagnosis and management of patients with psychiatric disorders ([Lewis, 1996][1]; [Costa et al , 1999][2]; [Longworth et al , 1999][3]). In old age psychiatry, a diagnosis of dementia is facilitated by structural and functional
Developmental pathways in depression: Multiple meanings, antecedents, and endpoints

Abstract This article presents an overview of work conducted at the Institute of Psychiatry over the past 30 years on childhood depression. The work began with the basic question of definition and measurement. Epidemiological studies showed that depressive symptoms were quite common in children and were a good, if nonspecific, indicator of psychological disturbance. Further work in both epidemiological and clinical samples provided some evidence for the validity of a depressive syndrome. However, this work also showed that these depressive syndromes represented a heterogeneous group of phenomena. The validity of major depressive disorder in children was therefore tested further in longitudinal and family-genetic studies. These studies supported the validity of the concept but confirmed that there was heterogeneity in respect to both developmental stage at the time of onset and comorbidity with conduct disorder. We concluded that there are probably several different kinds of depressive syndromes in children. Some are strongly linked with depressive disorders in adulthood, but others are probably better conceptualized as part of another psychopathological problem altogether.
VO2/power output relationship and the slow component of oxygen uptake kinetics during cycling at different pedaling rates: relationship to venous lactate accumulation and blood acid-base balance.

In this experiment we studied the effect of different pedalling rates during cycling at a constant power output (PO) 132+/-31 W (mean+/-S.D.), corresponding to 50% VO2 max, on the oxygen uptake and the magnitude of the slow component of VO2 kinetics in humans. The PO corresponded to 50% of VO2 max, established during incremental cycling at a pedalling rate of 70 rev.min(-1). Six healthy men aged 22.2+/-2.0 years with VO2 max 3.89+/-0.92 l.min(-1), performed on separate days constant PO cycling exercise lasting 6 min at pedalling rates 40, 60, 80, 100 and 120 rev.min(-1), in random order. Antecubital blood samples for plasma lactate [La]pl and blood acid-base balance variables were taken at 1 min intervals. Oxygen uptake was determined breath-by-breath. The total net oxygen consumed throughout the 6 min cycling period at pedalling rates of 40, 60, 80, 100 and 120 rev.min(-1) amounted to 7.727+/-1.197, 7.705+/-1.548, 8.679+/-1.262, 9.945+/-1.435 and 13.720+/-1.862 l, respectively for each pedalling rate. The VO2 during the 6 min of cycling only rose slowly by increasing the pedalling rate in the range of 40-100 rev.min(-1). This increase, was 0.142 l per 20 rev.min(-1) on the average. Plasma lactate concentration during the sixth minute of cycling changed little within this range of pedalling rates: the values were 1.83+/-0.70, 1.80+/-0.48, 2.33+/-0.88 and 2.52+/-0.33 mmol.l(-1). The values of [La]pl reached in the 6th minute of cycling were not significantly different from the pre-exercise levels. Blood pH was also not affected by the increase of pedalling rate in the range of 40-100 rev.min(-1). However, an increase of pedalling rate from 100 to 120 rev.min(-1) caused a sudden increase in the VO2 amounting to 0.747 l per 20 rev.min(-1), accompanied by a significant increase in [La]pl from 1.21+/-0.26 mmol.l(-1) in pre-exercise conditions to 5.92+/-2.46 mmol.l(-1) reached in the 6th minute of cycling (P<0.01). This was also accompanied by a significant drop of blood pH, from 7.355+/-0.039 in the pre-exercise period to 7.296+/-0.060 in the 6th minute of cycling (P < 0.01). The mechanical efficiency calculated on the basis of the net VO2 reached between the 4th and the 6th minute of cycling amounted to 26.6+/-2.7, 26.4+/-2.0, 23.4+/-3.4, 20.3+/-2.6 and 14.7+/-2.2%, respectively for pedalling rates of 40, 60, 80, 100 and 120 rev.min(-1). No significant increase in the VO2 from the 3rd to the 6th min (representing the magnitude of the slow component of VO2 kinetics) was observed at any of the pedalling rates (-0.022+/-0.056, -0.009+/-0.029, 0.012+/-0.073, 0.030+/-0.081 and 0.122+/-0.176 l.min(-1) for pedalling rates of 40, 60, 80, 100 and 120 rev.min(-1), respectively). Thus a significant increase in [La]pl and a decrease in blood pH do not play a major role in the mechanism(s) responsible for the slow component of VO2 kinetics in humans.
Stress, anger, and verbal aggression in intimate relationships: Moderating effects of individual and dyadic coping

Verbally aggressive exchanges between intimate partners are more likely during times of stress. Therefore, the present study examines (i) whether partners’ proneness to anger mediates the association between stress and verbal aggression and (ii) the degree to which individual and dyadic coping moderate associations among stress, anger, and aggression. Effective individual and dyadic coping reduces the effects of stress on aggression. Moreover, dyadic coping may attenuate associations between stress and both anger and verbal aggression. Individuals reporting adaptive and maladaptive coping typically differed in verbal aggression when stress was low, but not when stress was high. This is consistent with the notion that stressors govern strong negative emotion displayed in marriage. Implications of these findings for interventions that mitigate the effects of stress on relationships are discussed.
Bias in emerging biomarkers for bipolar disorder

Background To date no comprehensive evaluation has appraised the likelihood of bias or the strength of the evidence of peripheral biomarkers for bipolar disorder (BD). Here we performed an umbrella review of meta-analyses of peripheral non-genetic biomarkers for BD. Method The Pubmed/Medline, EMBASE and PsycInfo electronic databases were searched up to May 2015. Two independent authors conducted searches, examined references for eligibility, and extracted data. Meta-analyses in any language examining peripheral non-genetic biomarkers in participants with BD (across different mood states) compared to unaffected controls were included. Results Six references, which examined 13 biomarkers across 20 meta-analyses (5474 BD cases and 4823 healthy controls) met inclusion criteria. Evidence for excess of significance bias (i.e. bias favoring publication of ‘positive’ nominally significant results) was observed in 11 meta-analyses. Heterogeneity was high for (I 2 ⩾ 50%) 16 meta-analyses. Only two biomarkers met criteria for suggestive evidence namely the soluble IL-2 receptor and morning cortisol. The median power of included studies, using the effect size of the largest dataset as the plausible true effect size of each meta-analysis, was 15.3%. Conclusions Our findings suggest that there is an excess of statistically significant results in the literature of peripheral biomarkers for BD. Selective publication of ‘positive’ results and selective reporting of outcomes are possible mechanisms.
A Physiological Ligand of Positive Selection Is Recognized as a Weak Agonist1

Positive selection is a process that ensures that peripheral T cells express TCR that are self-MHC restricted. This process occurs in the thymus and requires both self-MHC and self-peptides. We have recently established a TCR transgenic (TCRtrans+) mouse model using the C10.4 TCR restricted to the MHC class Ib molecule, H2-M3. Having defined H2-M3 as the positively selecting MHC molecule, the severely limited number of H2-M3 binding peptides allowed us to characterize a mitochondrial NADH dehydrogenase subunit 1-derived 9-mer peptide as the physiological ligand of positive selection. Here, we demonstrate that the NADH dehydrogenase subunit 1 self-peptide is seen by mature C10.4 TCRtrans+ T cells as a weak agonist and induces positive selection at a defined concentration range. We also found that the full-length cognate peptide, a strong agonist for mature C10.4 TCRtrans+ T cells, initiated positive selection, albeit at significantly lower concentrations. At increased peptide concentrations, and thus increased epitope densities, either peptide only induced the development of partially functional T cells. We conclude that successful positive selection only proceeded at a defined, yet fairly narrow window of avidity.
Sentencing Female Misdemeanants: An Examination of the Direct and Indirect Effects of Race/Ethnicity

Little is known about the predictors of sentencing for the typical female offender—one who commits a misdemeanor or lesser offense. Moreover, although ample discussions of racial/ethnic disparity in sentencing may be found in the extant literature, most researchers have focused on what happens to males who commit felonies. Thus, to help fill a void I examine the likelihood of receiving a jail sentence among a sample of cases for female misdemeanants. All were convicted in New York City's Criminal Court. I account for direct and indirect effects by estimating a causal model that predicts the sentencing outcome. Race/ethnicity did not directly affect sentencing. Indirect effects, however, were found. Black and Hispanic females were more likely to receive jail sentences than their White counterparts due to differences in socio‐economic status, community ties, prior record, earlier case processing, and charge severity.