Miracle-dz/UniFAR-FTUs huggingface dataset:
Naturopathic Care for Anxiety: A Randomized Controlled Trial ISRCTN78958974

Background Anxiety is a serious personal health condition and represents a substantial burden to overall quality of life. Additionally anxiety disorders represent a significant cost to the health care system as well as employers through benefits coverage and days missed due to incapacity. This study sought to explore the effectiveness of naturopathic care on anxiety symptoms using a randomized trial. Methods Employees with moderate to severe anxiety of longer than 6 weeks duration were randomized based on age and gender to receive naturopathic care (NC) (n = 41) or standardized psychotherapy intervention (PT) (n = 40) over a period of 12 weeks. Blinding of investigators and participants during randomization and allocation was maintained. Participants in the NC group received dietary counseling, deep breathing relaxation techniques, a standard multi-vitamin, and the herbal medicine, ashwagandha (Withania somnifera) (300 mg b.i.d. standardized to 1.5% withanolides, prepared from root). The PT intervention received psychotherapy, and matched deep breathing relaxation techniques, and placebo. The primary outcome measure was the Beck Anxiety Inventory (BAI) and secondary outcome measures included the Short Form 36 (SF-36), Fatigue Symptom Inventory (FSI), and Measure Yourself Medical Outcomes Profile (MY-MOP) to measure anxiety, mental health, and quality of life respectively. Participants were blinded to the placebo-controlled intervention. Results Seventy-five participants (93%) were followed for 8 or more weeks on the trial. Final BAI scores decreased by 56.5% (p<0.0001) in the NC group and 30.5% (p<0.0001) in the PT group. BAI group scores were significantly decreased in the NC group compared to PT group (p = 0.003). Significant differences between groups were also observed in mental health, concentration, fatigue, social functioning, vitality, and overall quality of life with the NC group exhibiting greater clinical benefit. No serious adverse reactions were observed in either group. Relevance Many patients seek alternatives and/or complementary care to conventional anxiety treatments. To date, no study has evaluated the potential of a naturopathic treatment protocol to effectively treat anxiety. Knowledge of the efficacy, safety or risk of natural health products, and naturopathic treatments is important for physicians and the public in order to make informed decisions. Interpretation Both NC and PT led to significant improvements in patients' anxiety. Group comparison demonstrated a significant decrease in anxiety levels in the NC group over the PT group. Significant improvements in secondary quality of life measures were also observed in the NC group as compared to PT. The whole system of naturopathic care for anxiety needs to be investigated further including a closer examination of the individual components within the context of their additive effect. Trial Registration Controlled-Trials.com ISRCTN78958974
Tumor-Induced CD8+ T-Cell Dysfunction in Lung Cancer Patients

Lung cancer is the leading cause of cancer deaths worldwide and one of the most common types of cancers. The limited success of chemotherapy and radiotherapy regimes have highlighted the need to develop new therapies like antitumor immunotherapy. CD8+ T-cells represent a major arm of the cell-mediated anti-tumor response and a promising target for developing T-cell-based immunotherapies against lung cancer. Lung tumors, however, have been considered to possess poor immunogenicity; even so, lung tumor-specific CD8+ T-cell clones can be established that possess cytotoxicity against autologous tumor cells. This paper will focus on the alterations induced in CD8+ T-cells by lung cancer. Although memory CD8+ T-cells infiltrate lung tumors, in both tumor-infiltrating lymphocytes (TILs) and malignant pleural effusions, these cells are dysfunctional and the effector subset is reduced. We propose that chronic presence of lung tumors induces dysfunctions in CD8+ T-cells and sensitizes them to activation-induced cell death, which may be associated with the poor clinical responses observed in immunotherapeutic trials. Getting a deeper knowledge of the evasion mechanisms lung cancer induce in CD8+ T-cells should lead to further understanding of lung cancer biology, overcome tumor evasion mechanisms, and design improved immunotherapeutic treatments for lung cancer.
Functional substance P receptors on a rat pancreatic acinar cell line

A pancreatic acinar cell line, AR4–2J, that expresses a high density of substance P (SP)-binding sites has been identified. SP-binding sites on intact AR4–2J cells were detected with 125I-Bolton-Hunter SP (125I- BHSP). 125I-BHSP binding to AR4–2J cells has an apparent Kd of 40 pm with slow rates of association and dissociation. The number of high affinity binding sites was about 10(4)/cell. Binding of 125I-BHSP was inhibited by SP and by structurally related peptides. Physalaemin was a more potent inhibitor of binding than SP, whereas kassinin, eledoisin, and neurokinin A (substance K, neuromedin alpha, or neurokinin L) were much less potent. SP-free acid and SP (7–11) were 3 to 4 orders of magnitude less potent than SP itself. The membrane, intracellular, and secretory events elicited by exposure of AR4–2J cells to SP have also been examined. Intracellular recording from AR4–2J cells revealed resting membrane potentials of -40 to -65 mV. Pressure application of SP (100 pM to 100 nM) evoked depolarizations of 20 to 40 mV which were maintained for prolonged periods. The intracellular free calcium concentration in AR4–2J cells, measured with (2-[2-amino-5- methylphenoxy)-methyl)-6-methoxy-8-aminoquinolone tetra-acetoxy methyl ester), was between 100 and 500 nM. Addition of SP (100 pM to 10 nM) or physalaemin (1 nM) induced a transient rise in intracellular free calcium. AR4–2J cells synthesize amylase, and exposure of cells to SP resulted in a dose-dependent increase in amylase secretion. (ABSTRACT TRUNCATED AT 250 WORDS)
Predicting the properties of the remnants of dissipative galaxy mergers

We construct a physically motivated model for predicting the properties of the remnants of gaseous galaxy mergers, given the properties of the progenitors and the orbit. The model is calibrated using a large suite of smoothed particle hydrodynamics (SPH) merger simulations. It implements generalized energy conservation while accounting for dissipative energy losses and star formation. The dissipative effects are evaluated from the initial gas fractions and from the orbital parameters via an ‘impulse’ parameter, which characterizes the strength of the encounter. Given the progenitor properties, the model predicts the remnant stellar mass, half-mass radius and velocity dispersion to an accuracy of 25 per cent. The model is valid for both major and minor mergers. We provide an explicit recipe for semi-analytic models of galaxy formation.
How College Affects Students: Toward the Reconciliation of Theory With Empirical Evidence

Previous research has generally shown a very small although statistically significant economic benefit from attending high-quality colleges. This small effect was at odds with what students’ college choices and various social theories would seem to suggest. This study sought to reconcile the empirical evidence and theories. The effort was in two directions. First, the economic effect of college quality was reexamined—not only for an “average” student, but also for different students. Second, the effect of college quality was expanded from examining only the economic benefit to considering other student outcomes, including job satisfaction and graduate degree accomplishment. A new perspective regarding the social role of college quality was offered in conclusion.
Nonlinear motion correction of respiratory-gated lung SPECT images

We propose a method for correcting the motion of the lungs between different phase images obtained by respiratory-gated single photon emission computed tomography (SPECT). This method is applied to SPECT images that show a preserved activity distribution in the lungs such as 99m-Tc macro aggregated albumin (99m-Tc-MAA) perfusion images and 99m-Tc-Technegas ventilation images. In the proposed method, an objective function, which consists of both the degree of similarity between a reference image and a deformed image, and the smoothness of deformation is defined and optimized using a simulated annealing algorithm. For the degree of similarity term in the objective function, an expansion ratio, defined as the ratio of change in local volume due to deformation, is introduced to preserve the total activity during the motion correction process. This method was applied to data simulated from computer phantoms, data acquired from a physical phantom, and 17 sets of clinical data. In all cases, the motion correction between inspiration and expiration phase images was successfully achieved.
The SAGE Handbook of Organizational Institutionalism

Introduction - Royston Greenwood, Christine Oliver, Kerstin Sahlin and Roy Suddaby PART ONE: FOUNDATIONAL THEMES Legitimacy in Organizational Institutionalism - David L Deephouse and Marc Suchman Isomorphism, Diffusion and Decoupling - Eva Boxenbaum and Stefan Jonsson Institutional Logics - Patricia H Thornton and William Ocasio Organizational Fields - Melissa Wooten and Andrew J Hoffman Past, Present and Future PART TWO: INSTITUTIONAL DYNAMICS The Work of Meanings in Institutional Processes and Thinking - Tammar B Zilber Power, Institutions and Organizations - Thomas B Lawrence Institutional Entrepreneurship - Cynthia Hardy and Steve Maguire Circulating Ideas - Kerstin Sahlin and Linda Wedlin Imitation, Translation and Editing Organizational Implications of Institutional Pluralism - Matthew S Kraatz and Emily S. Block Microfoundations of Institutional Theory - Walter W Powell and Jeannette A. Colyvas Institutions and Transnationalization - Marie-Laure Djelic and Sigrid Quack PART THREE: APPLICATIONS Traditions as Institutionalized Practice - M Tina Dacin and Peter A Dacin Implications for de-institutionalization New Forms as Settlements - Hayagreeva Rao and Martin Kenney Social Movements and Failed Institutionalization - Gerald F Davis and Peter J J Anderson Corporate, (Non)Response to the AIDS Epidemic Institutions and Corporate Governance - Peer C Fiss PART FOUR: INTERFACES Beyond Constraint - Mary Ann Glynn How Institutions Enable Identities Institutionalism and the Professions - Kevin T Leicht and Mary L Fennell Institutionalism and Globalization Studies - Gili S Drori Organizational Institutionalism and Sociology - C R Hinings and Pamela S Tolbert A Reflection Coalface Institutionalism - Stephen R Barley New Sociology of Knowledge - Renate E Meyer Historical Legacy and Contributions Systems Theory, Societal Contexts and Organizational Heterogeneity - Raimund Hasse and Georg Kr cken Charting Progress at the Nexus of Institutional Theory and Economics - Peter W Roberts Ecologists and Institutionalists - Heather A Haveman and Robert J David Friends or Foes? Networks and Institutions - Jason Owen-Smith and Walter W Powell Institutional-Level Learning - Pamela Haunschild and David Chandler Learning as a Source of Institutional Change Social Movements and Institutional Analysis - Marc Schneiberg and Michael Lounsbury Examining 'Institutionalization' - David J Cooper, Mahmoud Ezzamel and Hugh Willmott A Critical Theoretic Perspective Taking Social Construction Seriously - Nelson Phillips and Namrata Malhotra Extending the Discursive Approach in Institutional Theory Institutional Leadership - Marvin Washington, Kimberly B Boal and John N Davis Past, Present and Future PART FIVE: REFLECTIONS Is the New Institutionalism a Theory? - Donald Palmer, Nicole Biggart and Brian Dick How to Misuse Institutions and Get Away with It - Barbara Czarniawska Some Reflections on Institutional Theory(ies) Been There, Done That, Moving on - Paul Hirsch Reflections on Institutional Theory's Continuing Evolution Reflections on Institutional Theories of Organizations - John W Meyer
Ultrastructural Organization of Bovine Chromaffin Cell Cortex—Analysis by Cryofixation and Morphometry of Aspects Pertinent to Exocytosis

We have analyzed ultrathin sections from isolated bovine chromaffin cells grown on plastic support, after fast freezing, by quantitative electron microscopy. We determined the size and intracellular distribution of dense core vesicles (DVs or chromaffin granules) and of clear vesicles (CVs). The average diameter of DVs is 356 nm, and that of CVs varies between 35–195 nm (average 90 nm). DVs appear randomly packed inside cells. When the distance of the center of DVs to the cell membrane (CM) is analyzed, DV density is found to decrease as the CM is approached. According to Monte Carlo simulations performed on the basis of the measured size distribution of DVs, this decay can be assigned to a “wall effect. ” Any cortical barrier, regardless of its function, seems to not impose a restriction to a random cortical DV packing pattern. The number of DVs closely approaching the CM (docked DVs) is estimated to be between 364 and 629 (average 496), i.e., 0.45 to 0.78 DVs/μm2 CM. Deprivation of Ca2+, priming by increasing [Ca2+]i, or depolarization by high [K+]e for 10 s (the effect of which was controlled electrophysiologically and predicted to change the number of readily releasable granules [RRGs]) does not significantly change the number of peripheral DVs. The reason may be that (a) structural docking implies only in part functional docking (capability of immediate release), and (b) exocytosis is rapidly followed by endocytosis and replenishment of the pool of docked DVs. Whereas the potential contribution of DVs to CM area increase by immediate release can be estimated at 19–33%, that of CVs is expected to be in the range of 5.6–8.0%.
The Study of a Novel Sorafenib Derivative HLC-080 as an Antitumor Agent

In this study, our objective is to evaluate the potential of a novel Sorafenib derivative, named HLC-080, as a new anticancer agent for colon cancer. We firstly carried out MTT assay, colony formation assay, flow cytometry analysis and transwell invasion assay to determine effect of our compound HLC-080 on cell viability, anti-proliferation activity, cell cycle arrest and the intervention on cell invasion, respectively. On the other hand, in vivo antitumor activity of HLC-080 was also tested using H22 xenograft model and the angiogenesis effect of HLC-080 was measured by EA.hy926 tube formation assay. The expression levels of various proteins in HLC-080 treated with HT-29 cell lines were examined using Western blot and ELISA experiments. The results showed that HLC-080 could dramatically inhibit the growth and colony formation of various tumor cells, therefore exhibited remarkable antitumor activity. HLC-080 can induce cell cycle arrest at G1 phase in HT-29 cells and subsequently inhibit the invasive potential of colon cancer cells. HLC-080 also exhibits anti-angiogenesis effect in EA.hy926 model. Additionally, the in vivo study showed that HLC-080 was able to reduced the tumor weight with the rate of 35.81%. And at the concentration of 0.352±0.034 µM, HLC-080 is able to reduce half of the regular protein level of p-c-Raf (Ser259), consequently block Raf/MEK/ERK signaling in HT-29 cell lines. In conclusion, our study suggests that Sorafenib derivative HLC-080 has the potential to inhibit cell proliferation and angiogenesis, Since, HLC-080 is particularly active against human colon cancer cells, our study highlights that HLC-080 and its related analogues may serve as a new anti-cancer drug, particularly against colon cancer.
Linguistic Determinants of Militancy and Terrorism in Nigeria: The Case of M.E.N.D and Boko Haram

This paper engages in the sociolinguistic profiling of militancy and terrorism in the Nigerian context. In this regard, it underpins the linguistic determinants of militancy and terrorism as revealed in the periodic statements of the Movement for the Emancipation of the Niger-Delta (hereafter, MEND) and Jama'atul Alhul Sunnah Lidda'wati wal jihad, otherwise known as Boko Haram. As a militant group, MEND seeks to defend the rights of the people of the Niger Delta against the predatory and corrupt Nigerian government and exploitations of the foreign energy companies. Boko Haram, an Islamic sect, seeks to establish a fully Islamic state in Nigeria through an armed revolt against the security forces of the Nigerian state. Over the years, these groups have continued to employ periodic statements intended to actualise their sectarian objectives. A number of statements from each of the two groups are analysed to evaluate the factors of phraseology and recurrent common themes. The picture, which emerges from the analysis, suggests that the common themes and phraseology in these statements revolve around their sectarian objectives, which show linguistic indicators of extremism, militancy and terrorism. Such flags and indicators offer a window of opportunity for law and security agencies to identify citizens of militant and terrorist propensity, with a view to synergizing preemptive and preventive intelligence infrastructure for countering militancy and terrorism in Nigeria. Keywords: linguistic determinants, militancy, terrorism, M.E. N.D, Boko Haram, security, Nigeria
210 King Street: a dataset for integrated performance assessment

This paper presents a Building Information Modeling (BIM) re-creation of a designated heritage building located in Toronto, Canada. By taking advantage of BIM as a centralized database, which describes both geometric and semantic aspects of a building, this model can be leveraged as a source of input for many forms of analysis. In addition to the BIM model, we present a comprehensive point cloud dataset gathered using terrestrial laser scanning technology. Based on an existing and a living building, this model is an ideal candidate for simulations that can be cross referenced with information gathered on-site.
Phylogenetic and molecular analysis of hydrogen-producing green algae

A select set of microalgae are reported to be able to catalyse photobiological H2 production from water. Based on the model organism Chlamydomonas reinhardtii, a method was developed for the screening of naturally occurring H2-producing microalgae. By purging algal cultures with N2 in the dark and subsequent illumination, it is possible to rapidly induce photobiological H2 evolution. Using NMR spectroscopy for metabolic profiling in C. reinhardtii, acetate, formate, and ethanol were found to be key compounds contributing to metabolic variance during the assay. This procedure can be used to test algal species existing as axenic or mixed cultures for their ability to produce H2. Using this system, five algal isolates capable of H2 production were identified in various aquatic systems. A phylogenetic tree was constructed using ribosomal sequence data of green unicellular algae to determine if there were taxonomic patterns of H2 production. H2-producing algal species were seen to be dispersed amongst most clades, indicating an H2-producing capacity preceded evolution of the phylum Chlorophyta.
Nonlinear activations for convolutional neural network acoustic models

Following their triumphs in visual recognition tasks, convolutional neural networks (CNNs) have recently been used to learn the emission probabilities of hidden Markov models in speech recognition. The key distinction of CNNs over deep neural networks (DNNs) is that they leverage translational invariance in the frequency domain, such that weights are shared and there are significantly fewer parameters to train. Since the acoustics of speech indeed display some translational invariance, CNNs could provide more powerful models than DNNs for various speech recognition tasks. Here, we compare the per-frame state classification accuracy of several popular nonlinear activation functions, both sigmoidal and rectified, for a small-scale CNN: the logistic function, the hyperbolic tangent function, the rectified linear unit, the leaky rectified linear unit, and the soft-plus function. We find that the leaky rectified linear unit and soft-plus function perform best by far, which suggests their potential in full-scale CNN acoustic models.
Dijkstra's Algorithm with Fibonacci Heaps: An Executable Description in CHR

We construct a readable, compact and efficient implementation of Dijkstra’s shortest path algorithm and Fibonacci heaps using Constraint Handling Rules (CHR), which is increasingly used as a high-level rule-based general-purpose programming language. We measure its performance in different CHR systems, investigating both the theoretical asymptotic complexity and the constant factors realized in practice.
Input and interaction in language acquisition: Child-directed speech and influences on language acquisition: methodology and interpretation

Introduction A survey of publications about language acquisition written from a variety of perspectives reveals how far a common body of research into environmental influences can be used to support opposing theoretical perspectives. A newcomer to the field would surely be bewildered by the proliferation of statements which seem directly to contradict each other. On the one hand we learn that “these results … certainly suggest that ‘motherese’ is an effective teaching language” (Furrow and Nelson 1986, p. 175) and “Considerable evidence … supports the view that particular aspects of adulttalk to children may affect how children learn to talk” (Lieven 1984, p. 15); on the other hand we read “It does not follow that it [motherese] is causally involved in the acquisition process itself, still less that motherese or any specifically modified form of input is necessary to language acquisition” (Smith 1989, p. 146), or, from a recent book on second language learning, “The effects of babytalk on children's first language development have been impossible to prove” (Cook 1991, p. 98). Snow, Perlmann, and Nathan (1987) ask what features of interaction with the child facilitate, or are necessary for, language acquisition. They conclude that, “This recurrent question has become, as more and more research is directed to it, not easier but more difficult to answer. Results of different studies are often contradictory” (Snow et al . 1987, p. 65). Just how contradictory is illustrated by Hardy-Brown (1983, table 1, p. 618).
Performance evaluation of the random replacement policy for networks of caches

Caching is a key component for Content Distribution Networks and new Information-Centric Network architectures. In this paper, we address performance issues of caching networks running the RND replacement policy. We first prove that when the popularity distribution follows a general power-law with decay exponent α > 1, the miss probability is asymptotic to O( C1-α) for large cache size C. We further evaluate network of caches under RND policy for homogeneous tree networks and extend the analysis to tandem cache networks where caches employ either LRU or RND policies.