Miracle-dz/UniFAR-FTUs huggingface dataset:
Frontal-Occipital Connectivity During Visual Search

Although expectation- and attention-related interactions between ventral and medial prefrontal cortex and stimulus category-selective visual regions have been identified during visual detection and discrimination, it is not known if similar neural mechanisms apply to other tasks such as visual search. The current work tested the hypothesis that high-level frontal regions, previously implicated in expectation and visual imagery of object categories, interact with visual regions associated with object recognition during visual search. Using functional magnetic resonance imaging, subjects searched for a specific object that varied in size and location within a complex natural scene. A model-free, spatial-independent component analysis isolated multiple task-related components, one of which included visual cortex, as well as a cluster within ventromedial prefrontal cortex (vmPFC), consistent with the engagement of both top-down and bottom-up processes. Analyses of psychophysiological interactions showed increased functional connectivity between vmPFC and object-sensitive lateral occipital cortex (LOC), and results from dynamic causal modeling and Bayesian Model Selection suggested bidirectional connections between vmPFC and LOC that were positively modulated by the task. Using image-guided diffusion-tensor imaging, functionally seeded, probabilistic white-matter tracts between vmPFC and LOC, which presumably underlie this effective interconnectivity, were also observed. These connectivity findings extend previous models of visual search processes to include specific frontal-occipital neuronal interactions during a natural and complex search task.
Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical

Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and hidroxy-phaeophytin new for the family Dictyotaceae, and; mannitol first described in this species. Saturated fatty acids as compared to the percentages of unsaturated fatty acids were shown to be present in greater abundance. Palmitic and linolenic acid were the main saturated and unsaturated acids, respectively. Cytotoxic and antioxidant activities were evaluated using human erythrocytes. In vivo evaluations of acute toxicity and genotoxicity were performed in mice. Methanolic extract of P. sanctae-crucis presented antioxidant activity and did not induce cytotoxicity, genotoxicity or acute toxicity. Since Padina sanctae-crucis is already used as food, has essential fatty acids for the nutrition of mammals, does not present toxicity and has antioxidant activity, it can be considered as a potential nutraceutical.
Electroluminescence and Transmission Electron Microscopy Characterization of Reverse-Biased AlGaN/GaN Devices

Reverse-bias stress testing has been applied to a large set of more than 50 AlGaN/GaN high electron mobility transistors, which were fabricated using the same process but with different values of the AlN mole fraction and the AlGaN barrier-layer thickness, as well as different substrates (SiC and sapphire). Two sets of devices having different defect types and densities, related to the different growth conditions and the choice of nucleation layer, were also compared. When subjected to gate-drain (or gate-to-drain and source short-circuited) reverse-bias testing, all devices presented the same time-dependent failure mode, consisting of a significant increase in the gate leakage current. This failure mechanism occurred abruptly during step-stress experiments when a certain negative gate voltage, or “critical voltage,” was exceeded or, during constant voltage tests, at a certain time, defined as “time to breakdown. ” Electroluminescence (EL) microscopy was systematically used to identify localized damaged areas that induced an increase of gate reverse current. This current increase was correlated with the increase of EL intensity, and significant EL emission during tests occurred only when the critical voltage was exceeded. Focused-ion-beam milling produced cross-sectional samples suitable for electron microscopy observation at the sites of failure points previously identified by EL microscopy. In high-defectivity devices, V-defects were identified that were associated with initially high gate leakage current and corresponding to EL spots already present in untreated devices. Conversely, identification of defects induced by reverse-bias testing proved to be extremely difficult, and only nanometer-size cracks or defect chains, extending vertically from the gate edges through the AlGaN/GaN heterojunction, were found. No signs of metal/semiconductor interdiffusion or extended defective areas were visible. The weak dependence on AlGaN properties, the strong process dependence, the time dependence, and the features of the localized damage identified by EL and electron microscopy suggest a multistep failure mechanism initiated by a process-induced weakness of the gate Schottky junction, which enhances current injection into pre-existing defects. As a result, further defects are generated or activated, eventually resulting in a percolation conductive path and permanent damage. A low-impedance path between the device gate and the channel is formed, increasing gate leakage current and possibly resulting in device burnout.
Cysteine Cross-linking Defines the Extracellular Gate for the Leishmania donovani Nucleoside Transporter 1.1 (LdNT1.1)*

Background: A computational model predicts the structure and gates of a nucleoside transporter. Results: Residues in the predicted extracellular gate were substituted by cysteine pairs and cross-linked. Conclusion: The predictions of the computational model for the extracellular gate are supported by experimental evidence. Significance: Defining the gates of a transporter is of fundamental importance for understanding its structure and function. Equilibrative nucleoside transporters are a unique family of proteins that enable uptake of nucleosides/nucleobases into a wide range of eukaryotes and internalize a myriad of drugs used in the treatment of cancer, heart disease, AIDs, and parasitic infections. In previous work we generated a structural model for such a transporter, the LdNT1.1 nucleoside permease from the parasitic protozoan Leishmania donovani, using ab initio computation. The model suggested that aromatic residues present in transmembrane helices 1, 2, and 7 interact to form an extracellular gate that closes the permeation pathway in the inward-open conformation. Mutation of residues Phe-48TM1 and Trp-75TM2 abrogated transport activity, consistent with such prediction. In this study cysteine mutagenesis and oxidative cross-linking were combined to analyze proximity relationships of helices 1, 2, and 7 in LdNT1.1. Disulfide bond formation between introduced paired cysteines at the interface of such helices (A61CTM1/F74CTM2, A61CTM1/G350CTM7, and F74CTM2/G350CTM7) was analyzed by transport measurement and gel mobility shifts upon oxidation with Cu (II)-(1,10-phenanthroline)3. In all cases cross-linking inhibited transport. However, if LdNT1.1 ligands were included during cross-linking, inhibition of transport was reduced, suggesting that ligands moved the three gating helices apart. Moreover, all paired cysteine mutants exhibited a mobility shift upon oxidation, corroborating the formation of a disulfide bond. These data support the notion that helices 1, 2, and 7 constitute the extracellular gate of LdNT1.1, thus further validating the computational model and the previously demonstrated importance of F48TM1 and Trp-75TM2 in tethering together helices that are part of the gate.
Language and Disputing

In an introductory essay on the anthropology of law, Laura Nader (159, p. 24) stressed the importance of attending to the "wrangling" involved in any dispute-i.e. to the argumentative forms, stylistic devices, and other com­ municative resources upon which disputants and third parties rely in further­ ing their own interests or in attempting to resolve the conflict. Such a study of language use in dispute focuses on a critical juncture between social and linguistic anthropology. On the one hand lie broad issues of social organiza­ tion, political economy, and power; on the other are the often apparently minuscule specifics of pronoun choice, syntactic variation, and tum-taking. In the pursuit of conflict-and, occasionally, of its resolution-power and language articulate in complex ways. The studies discussed in this essay address the "wranglings" of disputing talk from a wide range of perspectives and with a variety of audiences in mind. It is, indeed, characteristic of this topic that those issues which some researchers assume as unproblematic are taken as most critical by others. Many legal anthropologists assume the language of conflicts to be important but relatively transparent, while many linguists become so involved with textual details that sociopolitical contexts are taken for granted. When the contributions of lawyers, deVelopmental psychologists, and conversational analysts are added, the literature represents a complicated mix. A number of survey articles are particularly helpful. Danet (48), Grimshaw (94), and White & Watson-Gegeo (215) cover a broad range of issues from linguistic, sociological, and ethnographic perspectives. The language of courtrooms and other formal legal contexts has been extensively reviewed (50,83,132,161,176,195). Levi (132) and Shuy (195) focus on the possible practical applications of such research. Finally, Shantz (194) has published a comprehensive analytical review of the literature on children's disputes.
Factors Influencing Recruitment of Non-Accounting Business Professionals into Internal Auditing

ABSTRACT: This paper examines factors affecting non-accounting business professionals' willingness to work in internal auditing. In a 2 × 6 experiment with 502 participants from across the country, we find that, in contrast to prior research examining accountants, business professionals have relatively favorable views of internal audit. Although they hold favorable views, participants were still less likely to apply for a position labeled as internal audit than an identical position with an alternate label. Varying the structure of internal audit, including job responsibilities, career path, and sourcing arrangement, did not affect participants' willingness to apply for an internal audit position. We also find that high academically performing participants are less likely to apply to work in internal audit. Finally, based on an additional survey of 46 business students, we find that lower academically performing students would be more interested in internal audit if it paid more, but higher academically p.
Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia

The transcription factor encoded by the E-twenty-six (ETS)-related gene, ERG, is an essential regulator of hematopoietic stem cell function and a potent human oncoprotein. Enforced expression of ERG in murine hematopoietic cells leads to the development of a well-characterized lymphoid leukemia and a less well-defined non lymphoid disease. To clarify the latter, we generated murine bone marrow chimeras with enforced Erg expression in engrafted hematopoietic progenitor cells. As expected, these mice developed lymphoid leukemia. However, the previously reported non lymphoid disease that developed was shown to be a uniform, transplantable leukemia with both erythroid and megakaryocytic characteristics. In vivo, this disease had the overall appearance of an erythroleukemia, with an accumulation of immature erythroblasts that infiltrated the bone marrow, spleen, liver, and lung. However, when stimulated in vitro, leukemic cell clones exhibited both erythroid and megakaryocytic differentiation, suggesting that transformation occurred in a bipotential progenitor. Thus, in mice, Erg overexpression induces the development of not only lymphoid leukemia but also erythro-megakaryocytic leukemia.
Effects of Differences in Working Memory Capacity on Patterns of Word Generation

In recent years, it has been reported that WM (working memory) is concerned with word generation, but many points regarding the relationship between the individual differences of WM capacity and the patterns of word generation remain unclear. This study is to investigate these unclear points by using three types of word fluency task with different strategies. Subjects were 28 healthy native speakers of Japanese with an average age of 22.46 ± 3.26 years old. The experimental design included the following two tasks: (1) Japanese reading span test: Subjects were divided into the high-span, middle-span, and low-span WM capacity groups on the basis of the proportion of words recalled correctly; and (2) Word fluency task (category, letter, and verb conditions): In this task, subjects gave as many words as possible that were associated with each stimulus word within 60 s; four stimulus words in each category were used with 12 words in all. As a result, it has become clear that the high-span group with larger WM capacity can generate more words in number than the other groups and is superior in word generating capacity to them and that the low-span group with smaller WM capacity is the highest in the proportion of words generated in the first 15 s when their vocabulary is abundant, while it is the lowest during 45-60 s when their vocabulary dries up. The results suggest that WM capacity is involved in the ability to extract appropriate vocabulary from long-term memory information in immediate response.
Basis mapping based boosting for object detection

We propose a novel mapping method to improve the training accuracy and efficiency of boosted classifiers for object detection. The key step of the proposed method is a non-linear mapping on original samples by referring to the basis samples before feeding into the weak classifiers, where the basis samples correspond to the hard samples in the current training stage. We show that the basis mapping based weak classifier is an approximation of kernel weak classifiers while keeping the same computation cost as linear weak classifiers. As a result, boosting with such weak classifiers is more effective. In this paper, two different non-linear mappings are shown to work well. We adopt the LogitBoost algorithm to train the weak classifiers based on the Histogram of Oriented Gradient descriptor (HOG). Experimental results show that the proposed approach significantly improves the detection accuracy and training efficiency of the boosted classifier. It also achieves high performance on public datasets for both pedestrian detection and general object detection tasks.
COMPARISON OF INTUBATING CONDITIONS AFTER ADMINISTRATION OF ORG 9426 ( ROCURONIUM )

We have assessed intubating conditions after administration of Org 9426 (rocuronium) 600 fig kg' at 60 or 90s in groups of 20 patients anaesthetized with thiopentone, nitrous oxide in oxygen and small doses of fentanyl, and compared the data with those obtained after suxamethonium 1 mg kg' in similar groups of patients. The influence of prior suxamethonium administration on the potency of Org 9426 was studied also by constructing a dose-response curve. Intubating conditions after Org 9426 were found to be clinically acceptable (good or excellent) in 95% of patients at 60 s and in all patients at 90 s and in all patients at both times after suxamethonium. The average time for the onset of block following Org 9426 at this dose was 89 s (which is shorter than with any of the currently available non-depolarizing neuromuscular blocking drugs); the duration of clinical relaxation (25% recovery of twitch height) 30 min. Prior administration of suxamethonium did not appear to influence the potency of Org 9426.
Activity profiles in adolescent netball: a combination of global positioning system technology and time-motion analysis

This study sought to understand the activity profiles of adolescent netball players in match play conditions. To date there has been no published research in this area and such findings would give important insights to inform the training and preparation of adolescent netball players. Twenty-two adolescent netball players (age 14.5 ± 0.5 y, stature 165 ± 5 cm, body mass 58.32 ± 7.43 kg) were analysed while competing in a specially arranged outdoors match of 6 x 10 min periods. The players were categorised into one of three positional groups. To track the players’ movement GPS units were worn located between the scapulas in a purpose built harness. The match was filmed so that post-match time-motion analysis could be carried-out. Both the GPS and time-motion analysis data was classified into one of six movement categories for analysis.Midcourt players covered the greatest distance per quarter (37.73 ± 17.39 m/min) with the Attacking players covering the least distance (35.42 ±11.66 m/min). The Attacking players covered the greatest distance per quarter through sprinting (8.5 ±16.2 m/qtr), travelling nearly twice the distance of the other two groups. When comparing the mean frequency and duration of movements from the GPS and time-motion analysis, there was a discrepancy between the two methods. The results from this study suggest that in adolescent netball Midcourt players cover the greatest distance per quarter while Attacking players cover the greatest distance through sprinting. A comparison between data from the GPS and time-motion analysis suggest that the GPS units used in this study under report the frequency and duration of high intensity movements.
Slow Adaptive $M$ -QAM With Diversity in Fast Fading and Shadowing

This paper investigates the performance of adaptive M-ary quadrature amplitude modulation (QAM) with antenna subset diversity. We consider a slow adaptive modulation (SAM) technique that adapts the constellation size to the slow variation of the channel due, for example, to shadowing. The proposed SAM technique is more practical than conventional fast adaptive modulation (FAM) techniques that require adaptation to fast-fading variations. Our results show that the SAM technique can provide a substantial increase in throughput with respect to fixed schemes while maintaining an acceptable low bit-error outage. We also compare SAM and FAM techniques, showing that the throughput of SAM can be, in many practical cases, close to that of FAM, despite the fact that SAM is less complex and requires a lower feedback rate. For example, using a set of possible modulations {4,16,64}-QAM with dual-branch maximal ratio combining reception, 5% outage at a bit-error probability of 10-2 and a median signal-to-noise ratio of 22 dB, SAM is capable of improving the mean spectral efficiency of fixed schemes from about 1.9 to 4.7 b/s/Hz, which is close to the 5.5 b/s/Hz achieved by FAM
Does Mindfulness Mediate the Relationship Between Parental Depressionand Negative Parenting Behaviors

Parental depression can interfere with numerous aspects of parents’ lives, including parenting behaviors. Previous research has explored the relationship between past parental depression or current depressive symptoms and negative parenting behaviors. The current study investigates two models of mediation to explain the relationship between parental depression and parenting. In the first, it explores whether mindfulness mediates the relationship between past depression severity and three parenting behaviors: withdrawn/disengaged parenting, low levels of positive parenting and poor monitoring/supervision. In the second, it explores whether mindfulness mediates the relationship between current depressive symptoms and four parenting behaviors: withdrawn/disengaged parenting, low levels of positive parenting, poor monitoring/supervision and inconsistent discipline. The sample draws from two research sites, one in Burlington, Vermont and the other in Nashville, Tennessee and included previously or currently depressed parents (n=121; mean age = 42.5 years, SD = 7.40 years, range = 24-69), and their 9-15 year old children (n=167; mean age = 11.40 years, SD = 2.30 years, range = 9-15). All participating parents and children completed written measures at the time of their initial assessment. The overall findings of this study indicate that parents’ current depressive symptoms, but not past depression severity, increase the risk of low levels of positive parenting and parenting with greater inconsistent discipline, and that these associations are mediated by a parent’s level of mindfulness.
Influence of application of chlorhexidine gel and curcumin gel as an adjunct to scaling and root planing: A interventional study

Background: Currently, the most common therapy for periodontal diseases consists of professional scaling and root planing (SRP). However, it was found to be of limited efficacy especially in areas which are inaccessible to periodontal instrumentation. Therefore, treatment strategies using antimicrobials in conjunction with conventional therapy have evolved. Thus, the study was undertaken with an. Aim: To evaluate the efficacy of application of chlorhexidine gel and curcumin gel as an adjunct to SRP. Materials and Methods: The study was conducted on thirty chronic periodontitis patients who were divided into two groups as control and experimental groups using a split-mouth design. After SRP chlorhexidine gel was applied in control and curcumin gel in experimental groups. The plaque index, gingival index, sulcus bleeding index, probing pocket depth were recorded at baseline and subsequently after 1 month and 45 days. Results: The results revealed that both chlorhexidine gel and curcumin gel have an effect on mild to moderate periodontal pockets in chronic periodontitis patients, but greater reduction was observed in the experimental group than the control group. Conclusion: It can be concluded that both control and experimental gel can be used as an adjunct to SRP, but the curcumin gel was more effective than the chlorhexidine gel in the treatment of mild to moderate periodontal pockets with a significant reduction in the indice scores when compared to the baseline values.
Selection and Characterization of Potential Baker's Yeast from Indigenous Resources of Nepal

The study aims to isolate the yeast strains that could be used effectively as baker's yeast and compare them with the commercial baker's yeast available in the market of Nepal. A total of 10 samples including locally available sources like fruits, Murcha, and a local tree “Dar” were collected from different localities of Bhaktapur, Kavre, and Syangja districts of Nepal, respectively. Following enrichment and fermentation of the samples, 26 yeast strains were isolated using selective medium Wallerstein Laboratory Nutrient Agar. From the differential tests which included morphological and microscopic observation and physiological and biochemical characterization such as nitrate reduction and lactose utilization tests, 8 strains were selected as possible Saccharomyces strain. The selected strains were further assessed for their efficient leavening ability by tests such as ethanol tolerance, osmotolerance, invertase test, and stress exclusion test. The three most potent strains ENG, MUR3B, and SUG1 isolated from grape, Murcha, and sugarcane, respectively, were used in the fermentation and baking of dough. These strains also carried a possibility of being used as industrial baker's yeast.