Miracle-dz/UniFAR-FTUs huggingface dataset:
The Secret to Successful Deep-Sea Invasion: Does Low Temperature Hold the Key?

There is a general consensus that today’s deep-sea biodiversity has largely resulted from recurrent invasions and speciations occurring through homogenous waters during periods of the Phanerozoic eon. Migrations likely continue today, primarily via isothermal water columns, such as those typical of Polar Regions, but the necessary ecological and physiological adaptations behind them are poorly understood. In an evolutionary context, understanding the adaptations, which allow for colonisation to high-pressure environments, may enable us to predict future events. In this investigation, we examine pressure tolerance during development, in the shallow-water neogastropod Buccinum undatum using thermally acclimated egg masses from temperate and sub-polar regions across the species range. Fossil records indicate neogastropods to have a deep-water origin, suggesting shallow-water species may be likely candidates for re-emergence into the deep sea. Our results show population level differences in physiological thresholds, which indicate low temperature acclimation to increase pressure tolerance. These findings imply this species is capable of deep-sea penetration through isothermal water columns prevailing at high latitudes. This study gives new insight into the fundamentals behind past and future colonisation events. Such knowledge is instrumental to understand better how changes in climate envelopes affect the distribution and radiation of species along latitudinal as well as bathymetric temperature gradients.
Multidisciplinary therapy of stage IIIA non-small-cell lung cancer: long-term outcome of chemoradiation with or without surgery.

BACKGROUND Stage IIIA non-small-cell lung cancer (NSCLC) is highly heterogeneous due to differences in the size of the primary tumor and the extent and location of nodal disease. Although the addition of surgery to chemoradiation did not improve overall survival (OS) for stage IIIA patients in a randomized intergroup trial (INT 0139), subset analyses of the trial suggest that a trimodality approach incorporating lobectomy may be superior to bimodality therapy with chemoradiation alone. METHODS We analyzed the outcomes of patients with stage IIIA NSCLC (T3N1, T1-3N2) treated at our center between January 2000 and December 2008. We compared OS for those undergoing definitive chemoradiation to those undergoing chemoradiation followed by either lobectomy or pneumonectomy. Demographic variables were balanced by propensity score analysis method. RESULTS In our analysis of 249 patients, the median age was 65 years, 43% were men, and 96.5% had N2 disease. Chemoradiation followed by lobectomy yielded superior OS compared with chemoradiation (median OS 39 months vs 22 months, P = .038 after propensity score adjustment). There was no significant survival benefit for pneumonectomy over chemoradiation (median survival 28 months vs 22 months, P = .534). CONCLUSIONS Our data corroborate the findings of the INT 0139 trial. We propose that a formal randomized trial be performed comparing chemoradiation followed by lobectomy vs definitive chemoradiation in patients with stage IIIA disease whose tumors are resectable by lobectomy. Our data do not support the incorporation of pneumonectomy in the management of stage IIIA patients with N2 disease.
Influence of La and Ce on Microstructure and Properties of Cu-Cr-Zr Alloy

The degassing and dedusting mechanism of La and Ce during non-vacuum melting process of Cu-Cr-Zr alloy were analyzed by thermodynamics. The gibbs free energy changes of reactions of La and Ce with some impurties such as O2, H2, S, P and Si, were calculated to discriminate the possibility of reaction during the melting process, respectively. In addition, the effect of La and Ce on microstructure and properties were studied. The results show that La and Ce can react with O2, H2, S, P and Si, which improves the effect of degassing and dedusting remarkably; the addition of La and Ce can eliminate pine-tree crystal, fine grain and clear grain bourdary.
A Dynamic Survey of Graph Labeling

A graph labeling is an assignment of integers to the vertices or edges, or both, subject to certain conditions. Graph labelings were first introduced in the mid-1960s. In the intervening years over 200 graph labelings techniques have been studied in over 3000 papers. Finding out what has been done for any particular kind of labeling and keeping up with new discoveries is difficult because of the sheer number of papers and because many of the papers have appeared in journals that are not widely available. In this survey, I have collected everything I could find on graph labeling. For the convenience of the reader, the survey includes a detailed table of contents and index. This edition has 267 new references that are identified with the reference number and the word "new" in the right margin.
JBASE: Joint Bayesian Analysis of Subphenotypes and Epistasis

Motivation: Rapid advances in genotyping and genome-wide association studies have enabled the discovery of many new genotype–phenotype associations at the resolution of individual markers. However, these associations explain only a small proportion of theoretically estimated heritability of most diseases. In this work, we propose an integrative mixture model called JBASE: joint Bayesian analysis of subphenotypes and epistasis. JBASE explores two major reasons of missing heritability: interactions between genetic variants, a phenomenon known as epistasis and phenotypic heterogeneity, addressed via subphenotyping. Results: Our extensive simulations in a wide range of scenarios repeatedly demonstrate that JBASE can identify true underlying subphenotypes, including their associated variants and their interactions, with high precision. In the presence of phenotypic heterogeneity, JBASE has higher Power and lower Type 1 Error than five state-of-the-art approaches. We applied our method to a sample of individuals from Mexico with Type 2 diabetes and discovered two novel epistatic modules, including two loci each, that define two subphenotypes characterized by differences in body mass index and waist-to-hip ratio. We successfully replicated these subphenotypes and epistatic modules in an independent dataset from Mexico genotyped with a different platform. Availability and implementation: JBASE is implemented in C++, supported on Linux and is available at http://www.cs. toronto.edu/∼goldenberg/JBASE/jbase.tar. gz. The genotype data underlying this study are available upon approval by the ethics review board of the Medical Centre Siglo XXI. Please contact Dr Miguel Cruz at mcruzl@yahoo.com for assistance with the application. Contact: anna.goldenberg@utoronto.ca Supplementary information: Supplementary data are available at Bioinformatics online.
Cerebral Blood Flow Measurements by Magnetic Resonance Imaging Bolus Tracking: Comparison with [15O]H2O Positron Emission Tomography in Humans

In six young, healthy volunteers, a novel method to determine cerebral blood flow (CBF) using magnetic resonance (MR) bolus tracking was compared with [15O]H2O positron emission tomography (PET). The method yielded parametric CBF images with tissue contrast in good agreement with parametric PET CBF images. Introducing a common conversion factor, MR CBF values could be converted into absolute flow rates, allowing comparison of CBF values among normal subjects.
Differences in daily life between semiprovisioned and wild‐feeding baboons

Activity budgets and social aspects of feeding, among the adult females in a group of semiprovisioned baboons that fed from a garbage dump were compared with those of adjacent wild‐feeding groups in Amboseli National Park, Kenya, during the dry seasons of 1984 and 1985. Statistically significant differences were found in time spent feeding, distance travelled, and the relationship between dominance rank and time spent feeding. The garbage‐feeding animals fed for 20% of the time and rested for almost 50%, in contrast to approximately 60% and 10%, respectively, for the wild‐feeding animals. Speed of travel, length of day‐route, and home range size were greatly reduced for the garbage‐feeding animals. Use of sleeping trees and day route were highly regular in contrast to the unprovisioned group. At the garbage dump, time spent feeding was correlated with dominance rank among the adult females of this study. This was not the case for feeding on wild foods. Human enriched food sources offer the opportunity to study limiting factors and relationships between ecology and behavior. However, these conditions lead to human–animal conflicts that may be to the animals' long‐term detriment. Conservation and management implications are discussed.
Analysis of Orthogonal and Biorthogonal Wavelet Filters for Image Compression

e present work we analyze the performance of orthogonal and Biorthogonal wavelet filters for image compression on variety of test images. The test images are of different size and resolution. The compression performance is measured, objectively peak signal to noise ratio and subjectively visual quality of image and it is found that Biorthogonal wavelets outperform the orthogonal ones in both the criteria. General Terms Image compression algorithms
Socio-Cultural Modeling through Decision-Theoretic Agents with Theory of Mind

PsychSim is an agent-based social simulation framework that captures a wide range of the individual and cultural differences exhibited in complex social scenarios. PsychSim takes a decision-theoretic approach to modeling Theory of Mind, giving its agents a rich space of beliefs and preferences. PsychSim also uses a unique piecewise linear representation language that allows it to reason backward from observed behavior to infer consistent parameter settings. We first applied PsychSim to the exploratory simulation of influence campaigns in the face of a heterogeneous socio-cultural arena of operations. More recently, we have used PsychSim in a range of simulation-based training systems designed to teach skills such as the correct use of language, gestures, and social norms of a foreign culture, cross-cultural negotiation, avoidance of risky behavior, and urban stabilization operations.
Dynamic Interaction of PTPμ with Multiple Cadherins In Vivo

There is a growing body of evidence to implicate reversible tyrosine phosphorylation as an important mechanism in the control of the adhesive function of cadherins. We previously demonstrated that the receptor protein tyrosine phosphatase PTPμ associates with the cadherin–catenin complex in various tissues and cells and, therefore, may be a component of such a regulatory mechanism (Brady-Kalnay, S.M., D.L. Rimm, and N.K. Tonks. 1995. J. Cell Biol. 130:977– 986). In this study, we present further characterization of this interaction using a variety of systems. We observed that PTPμ interacted with N-cadherin, E-cadherin, and cadherin-4 (also called R-cadherin) in extracts of rat lung. We observed a direct interaction between PTPμ and E-cadherin after coexpression in Sf9 cells. In WC5 cells, which express a temperature-sensitive mutant form of v-Src, the complex between PTPμ and E-cadherin was dynamic, and conditions that resulted in tyrosine phosphorylation of E-cadherin were associated with dissociation of PTPμ from the complex. Furthermore, we have demonstrated that the COOH-terminal 38 residues of the cytoplasmic segment of E-cadherin was required for association with PTPμ in WC5 cells. Zondag et al. (Zondag, G., W. Moolenaar, and M. Gebbink. 1996. J. Cell Biol. 134: 1513–1517) have asserted that the association we observed between PTPμ and the cadherin–catenin complex in immunoprecipitates of the phosphatase arises from nonspecific cross-reactivity between BK2, our antibody to PTPμ, and cadherins. In this study we have confirmed our initial observation and demonstrated the presence of cadherin in immunoprecipitates of PTPμ obtained with three antibodies that recognize distinct epitopes in the phosphatase. In addition, we have demonstrated directly that the anti-PTPμ antibody BK2 that we used initially did not cross-react with cadherin. Our data reinforce the observation of an interaction between PTPμ and E-cadherin in vitro and in vivo, further emphasizing the potential importance of reversible tyrosine phosphorylation in regulating cadherin function.
Energy Saving of Elevator Group Control Based on Optimal Zoning Strategy with Interfloor Traffic

In this paper, with interfloor traffic condition, the optimal zoning elevator group control strategy is studied aiming at energy saving. First, the energy consumption data of an elevator is analyzed and the energy consumption model is constructed. Then, the optimal zoning strategy for energy saving is designed and solved by genetic algorithm. In this algorithm, the energy conservation and the variance of round trip time are considered simultaneously. In addition, a simulation platform is developed and, by which, a testing model with tri-elevator and thirteen-floor building is constructed and the effectiveness of the energy saving optimal zoning strategy is tested. The results demonstrate that, compared with the traditional average zoning method, the new strategy can reduce the energy consumption by 10.38% and the average waiting time by 41.55%.
Asymptotic analysis of noisy fitness maximization, applied to metabolism & growth

We consider a population dynamics model coupling cell growth to a diffusion in the space of metabolic phenotypes as it can be obtained from realistic constraints-based modeling. In the asymptotic regime of slow diffusion, that coincides with the relevant experimental range, the resulting non-linear Fokker–Planck equation is solved for the steady state in the WKB approximation that maps it into the ground state of a quantum particle in an Airy potential plus a centrifugal term. We retrieve scaling laws for growth rate fluctuations and time response with respect to the distance from the maximum growth rate suggesting that suboptimal populations can have a faster response to perturbations.
The decision to receive influenza vaccination among nurses in North and South Dakota.

OBJECTIVES We examined the relationships between factors (intention, habit, facilitating conditions, and social, cognitive, and affective factors) and nurses' decisions about influenza vaccinations to understand why some get vaccinated while others do not. DESIGN AND SAMPLE In a descriptive correlational design, the Triandis model of interpersonal behavior was used to examine the decision of nurses to receive influenza vaccinations. Participants were a random sample (N=193) of registered nurses in North and South Dakota drawn from the respective state nursing licensing board lists. MEASURES Instrument construction and mail survey procedures followed Dillman's tailored design method. RESULTS The response rate exceeded 80%. The findings revealed significant, positive correlations among all model variables. Item analysis showed that false beliefs about influenza disease and vaccinations were prevalent and that there was a wide variation in employer support for nurses getting vaccinated. CONCLUSIONS Educational and social marketing strategies may improve nurse's knowledge about influenza disease and vaccine and increase vaccine uptake. Employers should be encouraged to promote and improve influenza vaccine accessibility in the workplace. Additional study is needed to understand how best to strengthen the influence of intention and habit on the decision of nurses to receive influenza vaccinations.
Higher education is associated with reduced risk of heart failure among patients with acute myocardial infarction: A nationwide analysis using data from the CVDNOR project

Aims Coronary heart disease (CHD) outcomes are characterised by socioeconomic gradients. Although heart failure (HF) is a severe complication of CHD, sparse evidence exists on the association between socioeconomic status and HF among coronary patients. This study aimed to explore potential educational differences in the risk of HF among acute myocardial infarction (AMI) patients in Norway during 2001–2009. Methods and results A total of 70,506 patients hospitalised for an incident (first) AMI and without history of HF were included in the analyses. Information on education was obtained from the Norwegian Education Database and categorised into primary, secondary or tertiary. In 12,487 (17.7%) patients, HF was present at admission or developed during the AMI hospitalisation (early-onset HF). Compared to patients with primary education, patients with secondary or tertiary education had 9% [incidence rate ratio (IRR) = 0.91; 95% confidence interval (CI): 0.87–0.94] and 20% (IRR = 0.80; 95% CI: 0.75–0.86) lower risks of early-onset HF, respectively. Of the 54,095 AMI patients discharged alive without concurrent HF, 6375 (11.8%) were subsequently hospitalised with or died from late-onset HF during a median follow-up period of 3.4 years. Compared to patients with primary education, those with secondary or tertiary education had 14% [hazard ratio (HR = 0.86; 95% CI: 0.82–0.91] and 27% (HR = 0.73; 95% CI: 0.66–0.80) lower risks of HF, respectively. Educational differences in the risk of HF were not influenced by gender. Conclusions We observed an inverse association between educational level and risk of HF. More efforts in preventing this severe complication of AMI among less educated patients may help to reduce the socioeconomic gap in survival following coronary events.
A Taguchi approach for investigation of solid particle erosion response of needle-punched nonwoven reinforced polymer composites: Part II

In the present work, the effect of fabric mat loading at different impingement angle and impact velocity were reported through solid particle erosion test rig on viscose fiber based needle-punched nonwoven fabric mat reinforced polymer composites. Three types of viscose fiber based fabric mats (VS200, VS400 and VS600 g/m2) were used as reinforcing material. The solid particle erosion wear behavior of viscose fiber based needle-punched nonwoven reinforced composites were evaluated using irregular shape silica sand particles of the size of 250, 350 and 450 µm with a varying stand-off distance (65, 75 and 85 mm), impingement angle (30°, 45°, 60°, 75° and 90°) and impact velocity (45, 54 and 65 m/s). Taguchi analysis was also carried out on the basis of design of experiments approach to establish the inter-dependence of operating parameters on erosion rate of the composites. Analysis of variance and signal-to-noise ratio have been performed on the measured data. The eroded surfaces of these composite samples were examined by scanning electron microscopy to examine the wear modes of the composites. However, Part I discussed the physical, mechanical and thermo-mechanical characterization of the same series of composites and concluded that all the mechanical properties were improving with the increase in fabric mat weight percentages. Furthermore in thermo-mechanical analysis, in the temperature range of 50–60℃ the damping factor (tan δ) values was found to increase and the peak values of tan δ was observed in the temperature range of 70–90℃ for all the composites.
Monitoring Acid–Base Titrations on Wax Printed Paper Microzones Using a Smartphone

This study describes the use of a smartphone for monitoring acid–base titrations on wax printed paper microzones. An array of twelve microzones of 5 mm diameter each was wax printed on filter paper. The analytical performance of the proposed devices was explored with acid–base titrations examples, where jaboticaba peel extract was used as a natural pH indicator. The color intensity was captured using a smartphone and analyzed through a free App named Photometrix®. Before titrations, color intensity versus pH was calibrated to be used as a reference in titrations as (i) strong acid versus strong base; (ii) strong base versus strong acid; and (iii) weak acid versus strong base. In all examples, images were obtained after the addition of each aliquot of titrant solutions. The obtained titration curves showed the same behavior as the conventional titration curves. After evaluating the feasibility of the proposed methodology, the concentration level of acetic acid was obtained in three vinegar samples. Although the obtained values ranged from 5% to 8% compared to the concentrations on the conventional method, the proposed methodology presented high analytical reliability. The calculated concentrations of acetic acid in three samples ranged from 3.87% to 3.93%, and the proposed methodology did not significantly differ from classic acid–base titration at a confidence level of 95%. The acid–base titration on paper-based devices is outstanding, since any titration can be completed within 5 min using 20 µL volumes. Besides, the use of a smartphone to capture images followed by analysis in a free app offers simplicity to all users. The proposed methodology arises as a new strand to be exploited in the diffusion of the analytical chemistry education field as well as an alternative for quantitative analysis with extremely simplified instrumentation.
SPCA2 Regulates Orai1 Trafficking and Store Independent Ca2+ Entry in a Model of Lactation

An unconventional interaction between SPCA2, an isoform of the Golgi secretory pathway Ca2+-ATPase, and the Ca2+ influx channel Orai1, has previously been shown to contribute to elevated Ca2+ influx in breast cancer derived cells. In order to investigate the physiological role of this interaction, we examined expression and localization of SPCA2 and Orai1 in mouse lactating mammary glands. We observed co-induction and co-immunoprecipitation of both proteins, and isoform-specific differences in the localization of SPCA1 and SPCA2. Three-dimensional cultures of normal mouse mammary epithelial cells were established using lactogenic hormones and basement membrane. The mammospheres displayed elevated Ca2+ influx by store independent mechanisms, consistent with upregulation of both SPCA2 and Orai1. Knockdown of either SPCA2 or Orai1 severely depleted Ca2+ influx and interfered with mammosphere differentiation. We show that SPCA2 is required for plasma membrane trafficking of Orai1 in mouse mammary epithelial cells and that this function can be replaced, at least in part, by a membrane-anchored C-terminal domain of SPCA2. These findings clearly show that SPCA2 and Orai1 function together to regulate Store-independent Ca2+ entry (SICE), which mediates the massive basolateral Ca2+ influx into mammary epithelia to support the large calcium transport requirements for milk secretion.