Miracle-dz/UniFAR-FTUs huggingface dataset:
Estimates of Radiogenic Cancer Risks

A methodology recently developed by the U.S. EPA for estimating the carcinogenic risks from ionizing radiation is described. For most cancer sites, the risk model is one in which age-specific, relative risk coefficients are obtained by taking a geometric mean of the coefficients derived from the atomic bomb survivor data using two different methods for transport risks from the Japanese to the U.S. population. The risk models are applied to estimate organ-specific risks per unit dose for a stationary population with mortality rates governed by 1980 U.S. vital statistics. With the exception of breast cancer, low-LET radiogenic cancer risk estimates are reduced by a factor of 2 at low doses and dose rates compared to acute high dose exposure conditions. For low dose (or dose rate) conditions, the risk of inducing a premature cancer death from uniform, whole body, low-LET irradiation is calculated to be 5.1 × 10−2 Gy−1. Neglecting nonfatal skin cancers, the corresponding incidence risk is 7.6 × 10−2 Gy−1. High-LET (alpha particle) risks are presumed to increase linearly with dose and to be independent of dose rate. High-LET risks are estimated to be 20 times the low-LET risks estimated under low dose rate conditions, except for leukemia and breast cancer where RBEs of 1 and 10 are adopted, respectively.
The availability of cloud-based services: Is it living up to its promise?

Cloud-based services have spread among customers, boasting a number of advantages over centralized and self-owned infrastructures. Clouds providers claim a higher resilience, due to the use of a large distributed array of servers and storage facilities. However, assessments of their actual availability are missing. Here an early attempt to provide a third-party assessment is presented. Though not disposing of first-hand measurements, we have collected data on outages from a number of sources. We use those data to evaluate the frequency and duration of outages. The average duration of outages appears to lie in the 8-10 hours range, with a significant dispersion. A statistical analysis through QQ-plots and mean excess plots shows that the tail of the distribution of outage durations is well modelled by a Generalized Pareto distribution.
Embedded Assessment in Project‐based Science Courses for the Gifted: Insights to inform teaching all students

The present study of gifted students’ views of assessment is aimed at understanding how the employment of Embedded Assessment for Learning (EAfL) framework in science courses for the gifted affects the students’ views throughout the learning process. The participants were 86 students in three programmes for the gifted who elected project‐based science courses. The data included questionnaires, distributed at the beginning and at the end of the assessment processes in each science course, and in‐depth interviews with 12 students, which were analysed according to three main themes: general view of assessment; assessment modes; and relationships between assessment and learning. The students viewed the EAfL framework as an integral part of the learning process, and perceived it as a means of expressing autonomous learning and a range of performances; characteristics that correspond with the students’ unique needs. In addition, students addressed cognitive and social processes they had undergone. This implies that assessment which is explicitly designed to promote learning in science courses is a powerful tool for teachers as well as for students, and contributes to meaningful learning.
A Normalization Model of Attentional Modulation of Single Unit Responses

Although many studies have shown that attention to a stimulus can enhance the responses of individual cortical sensory neurons, little is known about how attention accomplishes this change in response. Here, we propose that attention-based changes in neuronal responses depend on the same response normalization mechanism that adjusts sensory responses whenever multiple stimuli are present. We have implemented a model of attention that assumes that attention works only through this normalization mechanism, and show that it can replicate key effects of attention. The model successfully explains how attention changes the gain of responses to individual stimuli and also why modulation by attention is more robust and not a simple gain change when multiple stimuli are present inside a neuron's receptive field. Additionally, the model accounts well for physiological data that measure separately attentional modulation and sensory normalization of the responses of individual neurons in area MT in visual cortex. The proposal that attention works through a normalization mechanism sheds new light a broad range of observations on how attention alters the representation of sensory information in cerebral cortex.
Clinical Scoring for Diagnosis of Acute Lower Abdominal Pain in Female of Reproductive Age

Background. Obstetrics and gynecological conditions (OB-GYNc) are difficult to be differentiated from appendicitis in young adult females presenting with acute lower abdominal pain. Timely and correct diagnosis is clinically challenging. Method. A retrospective data analysis was performed on 542 female patients who were admitted to a tertiary care hospital with a chief complaint of acute lower abdominal pain. Diagnostic indicators of appendicitis and OB-GYNc were identified by stepwise multivariable polytomous logistic regression. Diagnostic performances of the scores were tested. Result. The developed clinical score is comprised of (1) guarding or rebound tenderness, (2) pregnancy, (3) sites of abdominal tenderness, (4) leukocytosis, (5) peripheral neutrophils ≥75%, and (6) presence of diarrhea. For diagnosis of appendicitis, the area under the ROC curve was 0.8696, and the sensitivity and specificity were 89.25% and 70.00%. For OB-GYNc, the corresponding values were 0.8450, 66.67%, and 94.85%, respectively. Conclusion. The clinical scoring system can differentiate the diagnosis of acute lower abdominal pain in young adult females. Time spent for diagnosis at the emergency room may be shortened, and the patients would be admitted to the appropriate departments in less time.
The role of diffusion-weighted MRI in the classification of liver hydatid cysts and differentiation of simple cysts and abscesses from hydatid cysts.

PURPOSE The purpose of this study is to identify the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in the classification of liver hydatid cysts (HCs) and their differentiation from simple cysts and liver abscesses. MATERIALS AND METHODS Twenty-two patients that were sent to our department with preliminary diagnoses of HCs or abscess were included in the study. Thirty lesions were evaluated. MRI included T1-weighted fast gradient echo, T2-weighted half-Fourier acquisition single-shot turbo spin echo, and DW single-shot echo planar pulse sequencing (b, 0, 50, and 1000 s/mm²). The apparent diffusion coefficient (ADC) values (mm²/s) of the HCs, abscesses, and simple cysts were calculated. RESULTS No statistically significant difference was found between the ADC values of type 1 and 3 (P > 0.05) HCs and of simple cysts and type 1 HCs (P > 0.05). The ADC values of abscesses were significantly lower than those of type 1 and type 3 HCs, and simple cysts. No statistically significant difference was found between the ADC values of abscesses and type 4 HCs (P > 0.05). Type 4 lesions exhibited significantly lower ADC values in comparison to type 1 and 3 HCs. CONCLUSION DW-MRI helps differentiate type 4 lesions from other cysts and can distinguish abscesses from hydatid cysts other than type 4 as well as from simple cysts. Type 1 HCs cannot be differentiated from simple cysts using ADC values alone, and type 4 lesions are indistinguishable from abscesses.
Positive Evidence and Preemption in the Second Language Classroom

In this paper we show that supplying positive evidence in the second language (L2) classroom does not necessarily trigger the appropriate L2 value of a parameter of Universal Grammar. The parameter we investigate is the verb movement parameter of Pollock (1989), which accounts for the fact that English and French adverbs differ as to where they occur in relation to the verb: In French the verb raises past the adverb, allowing the order SVAO but not SAV, whereas in English the verb does not raise, allowing SAV but not SVAO. Fifty-four francophone children (aged 11) in intensive English-as-a-second-language programs in Quebec, Canada, were exposed to a 2-week input flood of specially prepared materials containing English adverbs used naturalistically. No form-focused instruction or negative evidence on adverb placement was provided. Subjects were pretested immediately prior to the input flood, posttested immediately afterward, and again 3 weeks later, on four different tasks. On all tasks there is a change between pretest and posttest behavior, namely, a dramatic increase in use of the English SAV order but little or no decline in incorrect usage of SVAO. Results are also compared to groups reported in White (1991a, 1991b); the subjects in the present study differ from both groups in the previous studies. The results of the present study suggest that positive evidence does not serve to preempt the first language parameter setting in this case; acquiring the correct English SAV order did not lead to loss of incorrect SVAO. Implications of this result for theories of preemption and parameter setting in L2 acquisition are discussed.
“You Talk a Good Game”

This article represents one aspect of an inquiry into the gendered character of the address of British televised sports. To answer the research question, “Why are televised sports disproportionately popular with a male, and not female, television audience? ” football is chosen for analysis as one sport whose appeal has traditionally been limited to men. Using semiotics to enable the elicitation of a gendered address to a television audience, a match between England and Holland broadcast by ITV as part of Euro '96 was analyzed. The results prompt a consideration of how Easthope's delineation of three aspects of masculine style might inform an investigation into football's masculine address. Finally, the work of Gilligan on the gendering of psychological development theories is discussed to further identify masculine style in televised football.
The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis.

BACKGROUND AND AIMS The farnesoid X receptor (FXR) is an endogenous sensor for bile acids and inhibits bile acid synthesis by inducing small heterodimer partner (SHP) gene expression. The aim of this study was to investigate whether FXR is expressed by and modulates function of hepatic stellate cells (HSCs). METHODS The antifibrotic activity of FXR ligand was tested in 2 rodent models: the porcine serum and bile duct ligation (BDL). RESULTS Twelve-week administration of 1-10 mg/kg 6-ethyl chenodeoxycholic acid (6-ECDCA), a synthetic FXR ligand, to porcine serum-treated rats prevented liver fibrosis development and reduced liver expression of alpha1(I) collagen, TGF-beta1 and alpha-SMA mRNA by approximately 90%. Therapeutic administration of 6-ECDCA, 3 mg/kg, to BDL rats reduced liver fibrosis and alpha1(I) collagen, transforming growth factor (TGF)-beta1, alpha-SMA, and tissue metalloproteinase inhibitor (TIMP)-1 and 2 messenger RNA (mRNA) by 70%-80%. No protection was observed in BDL rats treated with CDCA, 3 mg/kg, and ursodeoxycholic acid, 15 mg/kg. FXR expression was detected in HSCs. Exposure of HSCs to FXR ligands caused a 3-fold increase of SHP, reduced alpha1(I)collagen and TGF-beta1 by approximately 60%-70% and abrogates alpha1(I) collagen mRNA up-regulation induced by thrombin and TGF-beta1. By retrovirus infection and small interference RNA, we generated SHP overexpressing and SHP-deficient HSC-T6. Using these cell lines, we demonstrated that SHP binds JunD and inhibits DNA binding of adaptor protein (AP)-1 induced by thrombin. CONCLUSIONS By demonstrating that an FXR-SHP regulatory cascade promotes resolution of liver fibrosis, this study establish that FXR ligands might represent a novel therapeutic option to treat liver fibrosis.
Three-dimensional trunk kinematics in golf: between-club differences and relationships to clubhead speed

The aims of this study were (i) to determine whether significant three-dimensional (3D) trunk kinematic differences existed between a driver and a five-iron during a golf swing; and (ii) to determine the anthropometric, physiological, and trunk kinematic variables associated with clubhead speed. Trunk range of motion and golf swing kinematic data were collected from 15 low-handicap male golfers (handicap = 2.5 ± 1.9). Data were collected using a 10-camera motion capture system operating at 250 Hz. Data on clubhead speed and ball velocity were collected using a real-time launch monitor. Paired t-tests revealed nine significant (p ≤ 0.0019) between-club differences for golf swing kinematics, namely trunk and lower trunk flexion/extension and lower trunk axial rotation. Multiple regression analyses explained 33.7–66.7% of the variance in clubhead speed for the driver and five-iron, respectively, with both trunk and lower trunk variables showing associations with clubhead speed. Future studies should consider the role of the upper limbs and modifiable features of the golf club in developing clubhead speed for the driver in particular.
The Performance-Maintenance (PM) Theory of Leadership: Review of a Japanese Research Program.

Kawazu, Yusuke, Nobuya Ogawa, and Jyuji Misumi 1974 "A psychophysiological study of leadership conditions: The interaction between placebo effects and leadership effects. " Proceedings of the 38th Annual Meeting of the Japanese Psychological Asso- ciation: 816-817 (in Japanese). Kerr, Steven, and John M. Jermier 1978 "Substitutes for leadership: Their meaning and measure- ment. " Organizational Be- havior and Human Perform-
From power to empowerment: A paradigm shift in leadership

This article argues that there has been a clear shift in leadership approaches from those where the leader is in control and commanding i.e., power-based leadership to one where there is empowerment. Here the power comes from the followers and is shared. Burns concepts of transactional and transformational leadership are used interchangeably with the concepts of power and empowerment respectively. Under power-based leadership are included great man and trait, behaviourist and contingency theories. The article argues how these theories fit under the power based paradigm. Included under empowerment-based leadership are visionary, moral, servant and cultural leadership approaches. The article argues why these theories fall under this paradigm by showing for example how power is shared through the development of followers into leaders themselves. South African Journal of Higher Education Vol. 22 (3) 2008: pp.575-587
Education, Education, Education! The vision of lifelong learning in the Kennedy, Dearing and Fryer reports

ABSTRACT The year 1997 witnessed the publication of three major policy reports related to the development of lifelong learning in the UK: the Kennedy, Dearing and Fryer reports on further, higher and continuing education, respectively. These reports produced responses from government, and underlay the consultative paper published early in 1998. This article examines these documents, not so much for the policies they propose, but for the conceptualisations of lifelong learning they contain. It concludes that, in this context, while the promotion of lifelong learning is to be welcomed, the documents suffer from three failings: they accord too much priority to vocational education and training; they betray a tendency to blame non‐participants, while placing responsibility on them for changing their behaviour; and they threaten economic and social exclusion for those who do not participate in the future.
The relationships between work characteristics and mental health: examining normal, reversed and reciprocal relationships in a 4-wave study

This longitudinal study examined the causal relationships between job demands, job control and supervisor support on the one hand and mental health on the other. Whereas we assumed that work characteristics affect mental health, we also examined reversed causal relationships (mental health influences work characteristics). Further, the topic of the appropriate time lag for testing causal relationships was addressed. Our hypotheses were tested in a 4-wave study among a heterogeneous sample of 668 Dutch employees using structural equation modelling. The results provide evidence for reciprocal causal relationships between the work characteristics and mental health, although the effects of work characteristics on well-being were causally predominant. The best model fit was found for a 1-year time lag. Compared to earlier—predominantly cross-sectional—results, the present study presents a stronger case for the effects of work characteristics on the development of strain. The results also emphasize the need for a dynamic view of the relationship between work and health; the one-directional viewpoint in many work stress models does not seem to fully capture the relations between work characteristics and well-being.
A Courageous Challenge: Linking Psychology with Practice

This book, an amazing summary by Çiğdem Kağıtçıbaşı of her long and great career, is unique in setting forth two clear assertions. She forcefully argues that (1) a new model of psychological/emotional interdependence is needed in order to reflect the worldwide trend towards modernization/urbanization, and (2) theory and practice are inseparable; the social scientist cannot be value-free. These assertions have created a number of strong features of this book, and all the more, are bound to animate discussions among its readers. In this essay review, we describe these key assertions, and then discuss problems embedded in them.
Human colorectal cancer progression correlates with LOX-induced ECM stiffening

Some solid tumors are characterized by extracellular matrix (ECM) remodeling and stiffening, which is related to solid tumor progression and aggression. However, the relationship between ECM stiffness and colorectal cancer (CRC) remains unclear. In this study, we investigated the relevance of ECM stiffness to clinicopathologic features using human CRC tissue microarrays. The results demonstrate that the expression of ECM components in CRC tissues is closely correlated with CRC progression and poor prognosis, which indicates that ECM stiffness may be associated with CRC development. We further studied lysyl oxidase (LOX) expression in CRC tissue and demonstrated that LOX expression is closely correlated with CRC progression. Previous studies showed that P-selectin-mediated platelet accumulation in CRC tissue may up-regulate LOX expression. Our findings indicate that P-selectin-mediated platelet aggregation may up-regulate LOX expression and enhance the remodeling and stiffening of the tumor ECM, which may promote the progression of colorectal cancer. Therefore, LOX may be a potential effective therapeutic target to treat colorectal cancer.
Comparative evaluation of an electrochemical bioreporter for detecting phenolic compounds

ABSTRACT In this study, we constructed an Escherichia coli-based electrochemical bioreporter (EB) harboring pLZCapR, which encodes the CapR regulatory protein (for phenol degradation) along with β-galactosidase, and examined its ability to detect phenolic compounds as compared with previously reported optical bioreporters (OBs) controlled by CapR and detected using a luminometer (OB-lum) or spectrophotometer (OB-spec). The recombinant E. coli bioreporter cells were immobilized in polyvinyl alcohol (PVA); p-aminophenyl-β-D-galactopyranoside (PAPG) was used as the enzymatic substrate; and electrochemical measurements were taken. The peak current obtained on cyclic voltammetry (CV) was used to measure the redox response of PAPG degradation. Our results revealed that the EB system showed a detection range of 10 nM to 10 mM phenol with a good lower detection limit (30 nM phenol). Furthermore, the detection time was dramatically lower for the EB system (15–20 min) compared to the OBs (∼6 hr). These responses were reliably repeatable with an acceptable standard deviation (±2.7%; n = 6), and the system showed good stability without loss of activity over 7 hr of operation or following 2 weeks of cold storage. Together, these results show that the EB system is faster and has a lower detection limit than the existing optical techniques.
Seeing Through the ‘Good Farmer's’ Eyes: Towards Developing an Understanding of the Social Symbolic Value of ‘Productivist’ Behaviour

Developments in the agricultural industry are requiring dramatic changes in the role of the farmer away from intensive production oriented approaches towards more sustainable forms of agriculture. While this may appear to require a relatively simply change in emphasis, production based roles not only contain economic value, but contain social value in that they are used to communicate status as a 'good farmer'. Thus, when farmers are asked to change approaches to agriculture, they are not only incurring economic costs but also social costs and this is rarely, if at all, acknowledged. This study uses a symbolic interactionist framework to investigate the symbolic meaning of intensive agricultural production: how crops/livestock are perceived by farmers, how they convey status, and how they are linked with the status of the farm family within the farming community. It concludes that understanding the true meaning of agricultural activities on the farm and considering these factors in the development of policy may reduce the potential loss of established farm families from the land and the subsequent loss of decades or even centuries of experience, knowledge and local history.
The construction of ‘illiterate’ and ‘literate’ youth: the effects of high-stakes standardized literacy testing

High-stakes standardized literacy testing is not neutral and continues to build upon the legacy of dominant power relations in the state in its ability to sort, select and rank students and ultimately produce and name some youth as illiterate in contrast to an ideal white, male, literate citizen. I trace the effects of high-stakes standardized testing by using the voices of 16 youth who failed the Ontario Secondary School Literacy Test (OSSLT) to illustrate how the ‘illiterate youth’ revealed to students, schools, and communities by this test is culturally and socially constructed. In an age where multiple literacies are more and more valued, standardized literacy testing acts as a form of social control projected upon the ‘adolescent’ body that has historically been deemed ‘other’ or ‘deficient. ’ Just as colonized subjects needed to be ‘civilized,’ so youth now need to acquire a state defined literacy in a competitive and fast paced learning environment. This article helps to demonstrate how power operates on marginalized youth through standardized literacy testing that is being used transnationally.
Teaching Behaviors and Styles of Low-Income Puerto Rican Mothers

This study describes the teaching behaviors of low-income Puerto Rican mothers and explores several contextual variables as possible predictors of those teaching behaviors. The participants were 80 mothers and their preschool children, half from the Bronx, New York, and half from Bayamón, Puerto Rico. The most frequently used teaching behaviors in a cognitive-perceptual task were visual cues, directives, and modeling. Modernity of childrearing beliefs, social support, and difficulty of child temperament were related to maternal teaching behaviors and styles. In multiple-regression analyses, social support and modernity of childrearing beliefs significantly predicted use of inquiries, praise, and a democratic style; maternal education was not a significant predictor.