Miracle-dz/UniFAR-FTUs huggingface dataset:
Active Control of Flow Separation Over an

Designing an aircraft without conventional control surfaces is of interest to aerospace community. In this direction, smart actuator devices such as synthetic jets have been proposed to provide aircraft maneuverability instead of control surfaces. In this article, a numerical study is performed to investigate the effects of unsteady suction and blowing oil airfoils. The unsteady suction and blowing is introduced at the leading edge of tile airfoil in the form of tangential jet. Numerical solutions are obtained using Reynolds-averaged viscous compressible Navier-Stokes equations. Unsteady suction and blowing is investigated as a means of separation control to obtain lift on airfoils. The effect of blowing coefficients oil lift. and drag is investigated. The numerical simulations are compared with experiments from tile Tel-Aviv University (TAU). These results indicate that unsteady suction and blowing can be used as a means of separation control to generate lift. on airfoils.
The Effects of Computerized Picture-Word Processing on Kindergartners' Language Development

Abstract Although researchers have encouraged early writing experiences for young children, teachers often write for children because young children have limited writing vocabulary, undeveloped spelling ability and insufficient eye-hand coordination skills. Many young children thus become frustrated with the tasks of writing and reading. The picture-word processor system allows users to write messages on a computer by simply pressing squares of picture-words on an electronic tablet without having to spell words or use extensive eye-hand coordination. This study involved 103 students from four kindergarten classes at an elementary school in Utah. Fifty-two students from two classes formed the treatment group; 51 students from two classes formed the control group. Each pair of students in the treatment group received instruction on the picture-word processor system for 15 minutes per day, four days a week, for six consecutive weeks. Results indicate that students who received the picture-word processor inst.
Attitude Extremity and Trust in Media

Media credibility would be a shallow research topic were it confined to popularity contests among media in national polls. But there is reason to believe judgments of trust (1) are associated with thinking, (2) are not always lightly made, and (3) can illuminate the connection between media use and cognition. The data reported in this study continue an inquiry into variables antecedent to audience evaluations of media, specifically what factors explain trust in media. ' Considering credibility as a dependent variable is not new; the 1951 Hovland group noted in the validation of their experimental manipulation that along with effects of source characteristics, the audience's evaluations [of trustworthiness of the source] ". were also affected by their
The Arabidopsis Dynamin-Related Protein2 Family Is Essential for Gametophyte Development[C][W]

Both the DRP2 family of classical dynamins and the plant-specific DRP1s are thought to be required for clathrin-mediated trafficking. This study shows that the Arabidopsis DRP2 and DRP1 families have distinct developmental roles. DRP2 function was found to be necessary for cell cycle progression in the early stages of both the male and the female gametophyte development. Clathrin-mediated membrane trafficking is critical for multiple stages of plant growth and development. One key component of clathrin-mediated trafficking in animals is dynamin, a polymerizing GTPase that plays both regulatory and mechanical roles. Other eukaryotes use various dynamin-related proteins (DRP) in clathrin-mediated trafficking. Plants are unique in the apparent involvement of both a family of classical dynamins (DRP2) and a family of dynamin-related proteins (DRP1) in clathrin-mediated membrane trafficking. Our analysis of drp2 insertional mutants demonstrates that, similar to the DRP1 family, the DRP2 family is essential for Arabidopsis thaliana development. Gametophytes lacking both DRP2A and DRP2B were inviable, arresting prior to the first mitotic division in both male and female gametogenesis. Mutant pollen displayed a variety of defects, including branched or irregular cell plates, altered Golgi morphology and ectopic callose deposition. Ectopic callose deposition was also visible in the pollen-lethal drp1c-1 mutant and appears to be a specific feature of pollen-defective mutants with impaired membrane trafficking. However, drp2ab pollen arrested at earlier stages in development than drp1c-1 pollen and did not accumulate excess plasma membrane or display other gross defects in plasma membrane morphology. Therefore, the DRP2 family, but not DRP1C, is necessary for cell cycle progression during early gametophyte development. This suggests a possible role for DRP2-dependent clathrin-mediated trafficking in the transduction of developmental signals in the gametophyte.
Effect of coronal flaring on apical extrusion of debris during root canal instrumentation using single-file systems.

AIM To evaluate the effect of coronal flaring on the amount of debris extruded apically during root canal preparation using the Reciproc, WaveOne (WO) and OneShape (OS) single-file systems. METHODOLOGY Ninety extracted single-rooted mandibular incisor teeth were randomly assigned to six groups (n = 15 for each group) for canal instrumentation. Endodontic access cavities were prepared in each tooth. In three of the six groups, coronal flaring was not performed; coronal flaring was performed with Gates-Glidden drills on all teeth in the remaining three groups. The canals were then instrumented with one or other of the following single-file instrument systems: Reciproc, WO and OS. Debris extruded apically during instrumentation was collected into pre-weighed Eppendorf tubes. The tubes were then stored in an incubator at 70 °C for 5 days. The weight of the dry extruded debris was established by subtracting the pre-instrumentation and post-instrumentation weight of the Eppendorf tubes for each group. Data were analysed using one-way analysis of variance (anova) and Tukey's post hoc tests (P = 0.05). RESULTS Reciproc and WO files without coronal flaring produced significantly more debris compared with the other groups (P < 0.05). There was no significant difference in apical extrusion of debris amongst the other groups (P > 0.05). CONCLUSIONS All single-file systems caused apical extrusion of debris. Performing coronal flaring prior to canal preparation reduced the amount of apically extruded debris when using Reciproc or WO systems.
Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans

Selenoproteins, in particular thioredoxin reductase, have been implicated in countering oxidative damage occurring during aging but the molecular functions of these proteins have not been extensively investigated in different animal models. Here we demonstrate that TRXR-1 thioredoxin reductase, the sole selenoprotein in Caenorhabditis elegans, does not protect against acute oxidative stress but functions instead together with GSR-1 glutathione reductase to promote the removal of old cuticle during molting. We show that the oxidation state of disulfide groups in the cuticle is tightly regulated during the molting cycle, and that when trxr-1 and gsr-1 function is reduced, disulfide groups in the cuticle remain oxidized. A selenocysteine-to-cysteine TRXR-1 mutant fails to rescue molting defects. Furthermore, worms lacking SELB-1, the C. elegans homolog of Escherichia coli SelB or mammalian EFsec, a translation elongation factor known to be specific for selenocysteine in E. coli, fail to incorporate selenocysteine, and display the same phenotype as those lacking trxr-1. Thus, TRXR-1 function in the reduction of old cuticle is strictly selenocysteine dependent in the nematode. Exogenously supplied reduced glutathione reduces disulfide groups in the cuticle and induces apolysis, the separation of old and new cuticle, strongly suggesting that molting involves the regulated reduction of cuticle components driven by TRXR-1 and GSR-1. Using dauer larvae, we demonstrate that aged worms have a decreased capacity to molt, and decreased expression of GSR-1. Together, our results establish a function for the selenoprotein TRXR-1 and GSR-1 in the removal of old cuticle from the surface of epidermal cells.
An in Vitro Approach to the Chronological Aging of Skin by Glycation of the Collagen: The Biological Effect of Glycation on the Reconstructed Skin Model

Abstract: Glycation is a slow, nonenzymatic reaction that takes place between free amino groups in proteins primarily from lysine and a reducing sugar such as glucose or ribose. In skin, this reaction creates new residues or formations of cross‐links (advanced glycation end products, AGEs) in the extracellular matrix of the dermis. The formation of these bridges between dermal molecules is supposed to be responsible for loss of elasticity or other properties of the dermis observed during aging. Glycation may therefore play an important role in chronologic aging. In order to examine this hypothesis, we have developed a reconstructed skin model made of a modified dermal compartment that is a fibroblast‐contracted collagen lattice prepared with preglycated collagen. The presence of AGEs (glycoxidation products) in the skin equivalents was evidenced using specific antibodies against carboxymethyllysine (CML). Several changes were observed after collagen glycation: (1) fibroblast shape and distribution (vimentin staining) were modified; (2) extracellular matrix molecules and the dermal‐epidermal junction zone seemed to be enhanced (procollagen I and III, collagen IV and VII stainings); (3) stainings for β1 and α6 integrins were also increased in the epidermal cell layer; and (4) collagenase activity was increased. To verify the biological effect of glycation, we used the well‐known glycation inhibitor aminoguanidine. After aminoguanidine treatment, we found a low CML amount and decreased distribution of markers previously overexpressed in glycated skin constructs. These in vitro findings were at least in part related to aging in vivo and demonstrate an actual effect of glycation in skin aging.
Cell length, nucleoid separation, and cell division of rod-shaped and spherical cells of Escherichia coli

By comparing the dimensions and DNA contents of normal rod-shaped Escherichia coli with those of mutants that grow as spheres or ellipsoids, we have determined that two parameters remain unchanged: the DNA/mass ratio and the average cell length (diameter, for spherical cells). In consequence, the average volumes and DNA contents of the spherical mutant cells are about four to six times greater than those of rod-shaped cells growing at a similar rate. In addition, it was found that cells of both rod and sphere forms had approximately the same number of nucleoids (as seen when the DNA was condensed after inhibition of protein synthesis). The nucleoids of the spherical cells therefore consist of four to six completed chromosomes each (polytene nucleoids). We suggest that the attainment of a minimum cell length is necessary for nucleoid separation after chromosome replication and that such a separation is itself a prerequisite for septum formation.
Status groups and altruistic behaviour in dictator games

We provide evidence on the effects of social status in the dictator game. With regard to average donations from and to status groups, it turns out that (a) the higher the status of the dictator, the more she donates, and (b) the higher the status of the recipient, the less she receives in donations. Both tendencies are proposed by altruism. On a lower level of aggregation, we find that altruism has the highest proportion of correct predictions among all theoretical concepts under consideration (i.e. altruism, warm-glow giving, in-group bias, noblesse oblige). Surprisingly, there are rarely pure altruists on the individual level. This points at well-known problems of aggregation in social science research and challenges, among others, experimental studies on the in-group bias.
Liver resection associated with better outcomes for single large hepatocellular carcinoma located in the same section

Abstract The influence of the anatomical location of single large hepatocellular carcinoma (HCC) on outcomes following hepatic resection (HR) is still unclear. This study examined the role of anatomical location profiles as prognostic markers for patients with single large HCC undergoing HR. A total of 374 consecutive patients with single large HCC undergoing HR between January 2009 and July 2013 were included. They were divided into group same section (SS) group (n = 171) and different sections (DS) group (n = 203) according to their tumor's anatomical location. Short- and long-term outcomes were compared between the two groups. More patients in group DS had intraoperative blood loss of >1000 mL and needed intraoperative blood transfusion than those in group SS. There were no significant differences regarding postoperative complications and 30-and 90-day mortality between the two groups. The overall survival (OS) and recurrence-free survival (RFS) rates were significantly higher in group SS than group DS. The subgroup analysis showed that tumor in the same section was associated with better prognosis than those in different sections for both patients with tumor of ⩽8 cm and of > 8 cm. Multivariate analysis revealed that age <60 years, portal hypertension, alpha-fetoprotein ≥400 ng/mL, tumor in different sections, microvascular invasion and poorly differentiated tumor are independent predictors of poor prognosis in patient with single large HCC. For patients with single large HCC, a tumor located in the same section may lead to better long-term survival and lower tumor recurrence rates than those in different sections following HR.
Australian Home Education: A Model

If home education is not just school in another place, how can we conceptualise it and how does it work? This paper considers the peculiar set of relationships that characterise home-educating families and traces their extension out into the wider community. It further shows how, through the ongoing family conversation, experiences gained from domestic occupation and accompanied excursions into the field of authentic adult practice are problematised, built into the developing family worldview, and adapted by individual members for their own personal learning. It is proposed that a more useful model for home education characterises the family as a community of learning practice. Such a perspective views home education as the modern development of a tradition older than schooling in its response to the problem of secondary socialisation in a developed society.
Workplace Stressors, Job Attitude, and Job Behaviors: Is Interpersonal Conflict the Missing Link?

This research examines a model focused on two acute workplace stressors—interpersonal conflict and work overload—and their interrelationships with role stress, emotional exhaustion, job attitude, working smart, job performance, and turnover intentions. The moderating role of working smart on the relationship between work overload and interpersonal conflict is also investigated. A model is tested using responses of sales employees working for four large financial institutions in South America. Findings indicate that work overload and interpersonal conflict mediate the impact of role stress on emotional exhaustion, job attitudes, and behaviors. Our findings also show that work overload plays a significant role in the stressor-strain process. Results are discussed with reference to previous findings and future research.
The transmitter release‐site CaV2.2 channel cluster is linked to an endocytosis coat protein complex

Synaptic vesicles (SVs) are triggered to fuse with the surface membrane at the presynaptic transmitter release site (TRSs) core by Ca2+ influx through nearby attached CaV2.2 channels [see accompanying paper: Khanna et al. (2007)Eur. J. Neurosci. , 26, 547–559] and are then recovered by endocytosis. In this study we test the hypothesis that the TRS core is linked to an endocytosis‐related protein complex. This was tested by immunostaining analysis of the chick ciliary ganglion calyx presynaptic terminal and biochemical analysis of synaptosome lysate, using CaV2.2 as a marker for the TRS. We noted that CaV2.2 clusters abut heavy‐chain (H)‐clathrin patches at the transmitter release face. Quantitative coimmunostaining analysis (ICA/ICQ method) demonstrated a strong covariance of release‐face CaV2.2 staining with that for the AP180 and intersectin endocytosis adaptor proteins, and a moderate covariance with H‐ or light‐chain (L)‐clathrin and dynamin coat proteins, consistent with a multimolecular complex. This was supported by coprecipitation of these proteins with CaV2.2 from brain synaptosome lysate. Interestingly, the channel neither colocalized nor coprecipitated with the endocytosis cargo‐capturing adaptor AP2, even though this protein both colocalized and coprecipitated with H‐clathrin. Fractional recovery analysis of the immunoprecipitated CaV2.2 complex by exposure to high NaCl (∼1 m) indicated that AP180 and S‐intersectin adaptors are tightly bound to CaV2.2 while L‐intersectin, H‐ and L‐clathrin and dynamin form a less tightly linked subcomplex. Our results are consistent with two distinct clathrin endocytosis complexes: an AP2‐containing, remote, non‐TRS complex and a specialised, AP2‐lacking, TRS‐associated subcomplex linked via a molecular bridge. The most probable role of this subcomplex is to facilitate SV recovery after transmitter release.
Cryptogenic cirrhosis: clinicopathologic findings at and after liver transplantation.

The incidence of cryptogenic cirrhosis (CC) has decreased since the discovery of hepatitis C virus (HCV), still the etiology in 5% of cases with cirrhosis remains unresolved. Our aims were to define the clinicopathologic features of CC at liver transplantation (LT), evaluate the post-LT course with outcome and define the possible pathogenetic mechanisms. 27/534 LT recipients (5%) over a period of 16.5 years were entered in the LT database as cases of CC. A detailed analysis of pre- and post-LT clinical and all liver pathology specimens was performed. Based on clinicopathologic findings, a more definite diagnosis was possible in 23 of 27 (85%): Nonalcoholic steatohepatitis (NASH) in 9 (33%), autoimmune liver disease (AILD) in 6 (22%), alcoholic liver disease in 4, secondary biliary cirrhosis in 2 and 1 each of hepatitis C and portal venopathy. 4/27 cases remained unresolved. In the NASH group, native livers had focal steatosis, Mallory's hyalin, glycogenated hepatocytic nuclei, high-grade inflammation, and 3+ bile duct proliferation. Large cell dysplasia was more common in this group compared to other patients. Two patients had recurrence of NASH after LT. In AILD group native livers had little or no bile duct proliferation. Two patients had recurrence in AILD group. Of 27 patients 19 are alive (70%) with a follow-up of 407-3647 days. Based on the study results, the following conclusions were reached: (1) CC results from varying etiologies, which can be defined by a careful clinicopathologic analysis in a majority (85%) of cases; (2) Nonalcoholic steatohepatitis (33%) and AILD (22%) are the common underlying causes of CC; and (3) Post-LT outcome for CC is disease dependent with, recurrent disease seen in both nonalcoholic steatohepatitis (22%) and autoimmune liver disease (33%).
Exploring the Principal's Contribution to School Effectiveness: 1980‐1995∗

ABSTRACT This article reviews research from 1980‐1995 exploring the relationship between principal leadership and student achievement. The focuses is on the substantive findings that emerged from the review. Earlier reports focused on conceptual and methodological issues. The general pattern of results drawn from this review supports the belief that principals exercise a measurable, though indirect effect on school effectiveness and student achievement. While this indirect effect is relatively small, it is statistically significant and supports the general belief among educators that principals contribute to school effectiveness and improvement. Moreover, the review suggests that previously described discrepancies in research results may be explained by the conceptual and methodological tools employed by researchers. We also emphasize the limitations of these studies. Even taken as a group they do not resolve the most important theoretical and practical issues concerning the means by which principals achi.
The impact of aerosols on simulated ocean temperature and heat content in the 20th century

Observational analyses have documented increases in global ocean temperature, heat content, and sea level in the 20th century. Previous studies argued that the observed ocean warming is a response to increasing greenhouse gases. We use a new climate model to decompose simulated ocean temperature changes into components attributable to subsets of anthropogenic and natural influences. The model simulates a positive trend in global ocean volume mean temperature from the mid 1950s to 2000, consistent with observational estimates. We show that for the period 1861–2000 aerosols have delayed the onset of ocean warming by several decades and reduced the magnitude of the transient warming by approximately two‐thirds when compared to the response that arises solely from increasing greenhouse gases. The simulated cooling signature from large volcanic eruptions in the late 19th and early 20th centuries is clearly visible in the subsurface ocean well into the middle part of the 20th century.
Validity of the California Verbal Learning Test–II in Multiple Sclerosis

Multiple sclerosis (MS) is a disease of the central nervous system where roughly 50% of patients exhibit cognitive impairment. Episodic memory defects are particularly common in MS and the California Verbal Learning Test: 2nd Edition (CVLT-II) was recommended for assessment in MS in a recently published consensus position paper. We investigated the validity of the CVLT-II in 351 MS patients and 69 demographically matched normal controls. MS patients performed significantly more poorly on 18 of the 23 measures examined. In addition to a general memory factor, factor analysis revealed five distinct factors conforming to measures of consolidation, primary/recency effect, proactive interference, and learning asymptote. The external validity of the CVLT-II was also supported by logistic regression analysis, which separated employed from work-disabled MS patients. We conclude that the CVLT-II is a valid test in MS and provides a rich constellation of verbal memory measures.