Miracle-dz/UniFAR-FTUs huggingface dataset:
Reliability and Validity of the SAINT: A Guided Self-Help Tool for People With Intellectual Disabilities

This study investigated the main psychometric properties of the Self Assessment and Intervention (SAINT), a unique and recently developed Guided Self-Help tool for people with intellectual disabilities (ID). Fifty-four adults with ID identified with symptoms of anxiety and/or depression completed the study. They were between 18 and 77 years old with a mean of 39.4 years of age (SD = 13.57). Participants were recruited from both community (n = 31, 57.4%) and inpatient settings (n = 23, 42.6%). The Glasgow Depression Scale-Learning Disabilities (GDS-LD) and Glasgow Anxiety Scale-Intellectual Disabilities (GAS-ID) were used as expert measures. Convergent validity, concurrent validity, test-retest, and internal consistency were all tested on the SAINT in comparison with the GDS-LD and GAS-ID as appropriate. There were no missing data from the questionnaires. Cronbach's alpha suggested high internal consistency for the SAINT questionnaire at 0.827 and interitem correlation for internal consistency of the SAINT for any item deleted ranged from 0.788 to 0.826. In terms of convergent validity using the Spearman's Rho correlation coefficient the SAINT showed significant correlation at the 0.01 level (2-tailed) with the GDS-LD (r = 0.707), GAS-ID worries subscale (r = 0.578). The correlation for test-retest (n = 20, 37%) between Time 1 and Time 2 was r = 0.897, p < . 01. The SAINT has demonstrated potential as a measure for investigating mental distress for people with ID. One of the unique benefits of the SAINT is that it has a different utility from other measures used in this study that focus on psychopathology. The SAINT has not been designed as a diagnostic tool and aims to get the person to recognize and report a set of symptoms that indicates mental distress and to employ coping strategies once identified.
Properties of some conformal field theories with M-theory duals

By studying classes of supersymmetric solutions of D = 11 supergravity with AdS5 factors, we determine some properties of the dual four-dimensional N = 1 superconformal field theories. For some explicit solutions we calculate the central charges and also the conformal dimensions of certain chiral primary operators arising from wrapped membranes. For the most general class of solutions we show that there is a consistent Kaluza-Klein truncation to minimal D = 5 gauged supergravity. This latter result allows us to study some aspects of the dual strongly coupled thermal plasma with a non-zero R-charge chemical potential and, in particular, we show that the ratio of the shear viscosity to the entropy density has the universal value of 1/4π.
Benign Epilepsy of Children with Centrotemporal EEG Foci: Intelligence, Behavior, and School Adjustment

Sixteen children aged 7–12 years with benign epilepsy of childhood and centrotemporal (Rolandic) EEG foci were investigated as regards intelligence, visuomotor coordination, behavior, and school adjustment. They were compared with partly the same‐sex class‐population, partly randomly selected class controls of the same sex and age. There were no differences between the children and their class controls regarding intelligence, behavior, and school adjustment. The epileptic seizures did not influence the children's intelligence. The visuomotor coordination was impaired in most children (tested by Bender's test), but this was not true for their verbal and nonverbal functions.
Tolerance of patients with human immunodeficiency virus and anal carcinoma to treatment with combined chemotherapy and radiation therapy.

PURPOSE To evaluate treatment tolerance in patients with and without the human immunodeficiency virus (HIV) who were undergoing treatment of anal cancer. MATERIALS AND METHODS The authors retrospectively reviewed the medical records of 62 patients with anal cancer who received radiation treatment. Seven patients had HIV, four of whom had acquired immunodeficiency syndrome. Fifty-five patients were HIV negative, including 11 patients identified as being at high risk for HIV infection whose status was unknown. RESULTS Thirty of the 55 (55%) patients who were HIV negative required treatment breaks of a mean duration of 16.7 days. Four of those 55 (7%) patients required hospitalization. Three of 42 (7%) patients who were HIV negative receiving chemotherapy required chemotherapy dose reduction. All seven patients with HIV required treatment breaks of a mean duration of 21.7 days. Three of the seven (43%) patients required hospitalization. Four of the seven (57%) patients required chemotherapy dose reduction. CONCLUSION Patients with HIV undergoing treatment of anal cancer have increased toxic reactions to chemoradiation. Treatment must be individually tailored on the basis of extent of disease and degree of compromise of the immune system.
Non-coding RNA and its potential role in Mycobacterium tuberculosis pathogenesis

It is estimated that one third of the human population is infected with Mycobacterium tuberculosis. Efforts to understand the molecular basis of its gene regulation have been focused on identification of protein encoding genes and regulons implicated in pathogenesis. Recently, a number of studies have described the identification of several non-coding RNAs that are likely to contribute significantly to the regulatory networks responsible for adaptation and virulence in M. tuberculosis. We have reviewed emerging information on the presence and abundance of different types of non-coding RNA in M. tuberculosis and consider their potential contribution to the adaptive responses that underlie disease pathogenesis.
Pathology in practice. Spina bifida aperta.

Vet Med Today: Pathology In Practice 1263 This report was submitted by Lorenzo Golini, DVM, MSc; Giovanni Di Guardo, DVM; Laurance Bonnafous, DVM; and Giuseppe Marruchella, DVM; from the Private Veterinary Practice “Casilina”, Via Casilina 983/ B, 00172 Rome, Italy (Golini); Department of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy (Di Guardo, Marruchella); and Pets and Sport Animals Department, Pherosynthese Research Center, Le Rieu Neuf, 84490 Saint Saturnin Les Apt, France (Bonnafous). Dr. Golini’s present address is Neurology Service, Clinic for Small Animal Surgery, Veterinary Teaching Hospital, VetSuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland. Address correspondence to Dr. Golini. Pathology In Practice In cooperation with
Selective and Nonselective Replication of an E 1 B-deleted Adenovirus in Hepatocellular Carcinoma 1

An E1B gene-attenuated adenovirus ( dl1520) has been proposed to have a selective cytolytic activity in cancer cells with a mutation or deletion in the p53 tumor suppressor gene (p53-null), a defect present in almost half of human hepatocellular carcinomas (HCCs). In this study, thein vitro and in vivo antitumor activity of dl1520 was investigated focusing on two human HCC cell lines, a p53-wild type (p53-wt) cell line and a p53-null cell line. dl1520 was tested forin vitro cytopathic effects and viral replication in the human HCC cell lines Hep3B (p53-null) and HepG2 (p53-wt). The in vivo antitumor effects of dl1520 were investigated in tumors grown s.c. in a severe combined immunodeficient mouse model. In addition, the combination of dl1520 infection with systemic chemotherapy was assessed in these tumor xenografts. At low multiplicities of infection, dl1520 had an apparent p53-dependentin vitro viral growth in HCC cell lines. At higher multiplicities of infection, dl1520 viral replication was independent of the p53 status of the target cells.In vivo, dl1520 significantly retarded the growth of the p53-null Hep3B xenografts, an effect augmented by the addition of cisplatin. However, complete tumor regressions were rare, and most tumors eventually grew progressively.dl1520 had no effect on thein vivo growth of the p53-wt HepG2 cells, with or without cisplatin treatment. The E1B-deleted adenoviral vectordl1520 has an apparent p53dependent effect in HCC cell lines. However, this effect is lost at higher viral doses and only induces partial tumor regressions without tumor cures in a human HCC xenograft model.
A Clinical Adverse Drug Reaction Prediction Model for Patients with Chagas Disease Treated with Benznidazole

ABSTRACT Benznidazole (BZN) is the main trypanocidal drug used to treat Chagas disease, and the evidence supporting the benefits of BZN use during the chronic phase of the disease will favor its use in millions of individuals. However, more than 30% of patients treated with BZN may suffer adverse drug reactions (ADRs), and the development of tools to identify those patients at risk is highly desirable. In the present study, we aimed to identify predictive factors for ADRs in Chagas disease patients treated with BZN. Among 195 patients included in the study, 48.7% experienced ADRs and 31.3% had ADRs that caused BZN treatment discontinuation. Overall ADRs and ADRs that caused BZN treatment discontinuation were more common among women and in those who graduated from elementary school. Overall ADRs were also less frequent among black individuals. Based on logistic regression analysis, female sex (odds ratio [OR], 2.9; 95% confidence interval [CI], 1.5 to 5.4), graduation from elementary school (OR, 2.0; 95% CI, 1.1 to 3.8), and white (OR, 5.0; 95% CI, 1.0 to 24.1) and mulatto (OR, 5.6; 95% CI, 1.1 to 28.7) races were considered to predict overall ADRs, and female sex (OR, 2.3; 95% CI, 1.2 to 4.3) was considered to predict ADRs that caused BZN treatment discontinuation. Graduation from elementary school also presented a tendency to predict ADRs that caused BZN treatment discontinuation (OR, 1.8; 95% CI, 0.9 to 3.6). The logistic regression (LR) models to predict ADRs to BZN described in this study may become important tools to minimize ADRs and improve patients' compliance and thus assist physicians treating patients with Chagas disease with BZN.
An LTCC Coupled Resonator Decoupling Network for Two Antennas

An integrated low-temperature co-fired ceramic (LTCC) coupled resonator decoupling network (CRDN) for two coupled antennas is proposed in this paper. By virtue of LTCC technology, a second-order CRDN is realized by two tightly coupled lumped-element resonators in a volume of 3.2×2.5×1.2 mm3. Theoretical analysis has revealed that a wide range of mutual admittance of a CRDN can be realized by choosing appropriate I/O coupling elements while the coupled resonators can be consolidated in an LTCC device. This “one-fit-all” feature allows for decoupling a wide range of coupled antennas with different form factors for a given frequency band. To prove the concept, two LTCC CRDNs for decoupling different forms of antennas working in the 2.45-GHz band are designed, fabricated, and tested. Measurement results have demonstrated that significant improvement in isolation can be achieved within a wide operating frequency range in all cases. The presented design theory and circuit topology are general and can be applied to both symmetric and asymmetric two-element antenna arrays.
A 14-mW PLL-Less Receiver in 0.18-  $\mu\hbox{m}$ CMOS for Chinese Electronic Toll Collection Standard

The design of a 14-mW receiver without phaselocked loop for the Chinese electronic toll collection (ETC) system in a standard 0.18-μm CMOS process is presented in this brief. Since the previously published work was mainly based on vehicle-powered systems, low power consumption was not the primary goal of such a system. In contrast, the presented system is designed for a battery-powered system. Utilizing the presented receiver architecture, the entire receiver only consumes 7.8 mA, at the supply voltage of 1.8 V, which indicates a power saving of at least 38% compared with other state-of-the-art designs for the same application. To verify the performance, the bit error rate is measured to be better than 10-6, which well satisfies the Chinese ETC standard. Moreover, the sensitivity of the designed receiver can be readjusted to -50 dBm, which is required by the standard.
The importance of teaching ethics of sustainability

Purpose – The purpose of this paper is to describe the importance of a focus on ethics in sustainability education and present results from a pilot graduate‐level course titled the Ethics of Sustainability.Design/methodology/approach – This is a case study presenting a qualitative evaluation from a pilot 14‐week Ethics of Sustainability course. Data are based on observations, surveys and interviews with students.Findings – Students from diverse fields found the ethical concepts new, stimulating and crucial for their careers. Ethical concepts provide a framework for thinking about sustainable practices in their personal and professional lives.Research limitations/implications – Findings are based on a single pilot course and post‐participation responses. Future research could explore different teaching strategies and different institutions, and use pre/post studies.Practical implications – This study suggests that a course on ethical principles related to sustainability is a useful and potentially critical.
Characterization of prenatal growth and development in the crab‐eating macaque (macaca fascicularis) by ultrasound

Diagnostic ultrasound is a valuable tool for the examination of various anatomical structures in vivo. Improvements in technology have increased its effectiveness and provided a noninvasive method for the in utero observation of a variety of structural and functional events. Ultrasound is utilized in our laboratory to monitor a variety of studies during embryonic and fetal development. Basic to these evaluations is the ability to assess normal growth and development. The cynomolgus, or crab‐eating macaque (Macaca fascicularis), has been observed in utero by ultrasound from early gestation to term. The earliest detection of implantation is by the identification of a developing gestational sac (GS), which may be visualized on gestational day (GD) 14–15. Positive identification of the GS on GD 16–18 and appearance of the embryo, yolk sac, and cardiac motion on GD 21–25 confirms pregnancy. Once the embryo is evident, measurements of the greatest length (GL) may be used to assess normal growth or to aid in the prediction of gestational age. During the fetal period, a variety of growth parameters aid in fetal evaluation. The gender of the fetus can be accurately identified as early as GD 70–75. An assessment of viability and condition can be determined by the observation of embryonic and fetal heart rates and gross body movement.
Survey Nonrespondents as Bad Soldiers: Examining the Relationship between Organizational Citizenship and Survey Response Behavior

The present paper examines whether organizational survey response behavior relates to organizational citizenship behavior (OCB). In Study 1, we examined the relationship between OCB dimensions and survey completion intentions in a field setting (n=228). In Study 2, we compared respondents and different groups of nonrespondents on OCB dimensions using an experimental design in a university setting (n=622). Survey response and OCBs were found to be related. OCB research may suffer from nonresponse bias, with organizational surveys failing to capture the opinions of those least likely to engage in OCBs.
Establishing a Formal Cross-Cultural Mentoring Organization and Program: A Case Study of International Student Mentor Association in a Higher Education Context.

Purpose – The aim of this paper is to offer potential insight regarding formal cross‐cultural mentoring organization and program development in higher education contexts and beyond, by elaborating regarding the founding and programmatic efforts of an International Student Mentor Association (ISMA) at a large university in North America.Design/methodology/approach – The research approach used was an exploratory case study. Data were collected from various secondary sources. As ex‐post factor reporting, data analysis was also based on memory and experiences recalled by the first author – one of the ISMA founding members.Findings – ISMA was distinctive in employing cross‐cultural mentoring. International, cultural components were embedded in the overall organization structure, board and team designs, paired mentor system, mentor and protege matching, training content, and multilevel mentoring activities. Organization and program flow charts were identified.Research limitations/implications – Future research .
Interactive Behaviors in Adolescent Conversation Dyads.

PURPOSE Verbal and nonverbal conversational behaviors often are the target of intervention for adolescents with social communication disorders. There are, however, few sources of data on the interactive conversational behaviors of typically developing adolescents that can be used as guidelines when working with clinical populations. The purpose of this study was to collect behavioral data from conversations of adolescents so as to provide comparison data for adolescents with communication disorders. METHOD Conversational behaviors were measured in 50 typically developing African American and Caucasian adolescents (24 females, 26 males) from the Midwest United States who engaged in extemporaneous, 3-minute conversations in dyads with peers. The effects of age, race, and sex of the participant were assessed. RESULTS Behaviors occurring at relatively high frequencies included directing gaze at the partner, particularly during listening; nodding and showing neutral and positive facial expressions; using back-channel responses; and giving contingent responses. Participants rarely showed negative emotions, turned away from each other, asked for clarification, or failed to answer questions. Overall, there were few effects of race and sex of the speaker and greater variability within than between groups. CLINICAL IMPLICATIONS The data may serve as a source of information for clinicians serving individuals with communication disorders, with the caveat that the conversations included here represent a subset of typical adolescent interactive conversational behaviors.
Age‐dependent gene expression profile and protein expression in a transgenic rat model of Huntington's disease

Polyglutamine‐induced changes in gene expression have been demonstrated by using several mouse models of Huntington's disease (HD), which express extreme numbers of CAG repeats. We have recently developed a transgenic rat model of HD carrying a truncated huntingtin fragment with 51 CAG repeats, which is in the range seen in adult HD patients. For further evaluation, we have performed microarray analyses on whole brains of transgenic rats at 3 and 12 months of age and correlated it with protein expression by Western blot analysis. We found that genes functionally associated with gene expression and behavior were differently regulated already at 3 months of age, whereas at 12 months of age especially genes related to neurological diseases and cell‐to‐cell signaling and interaction were dysregulated. A detailed analysis of canonical pathways revealed that at 3 months of age genes in calcium signaling and synaptic long term potentation pathways were altered, while at 12 months of age, additionally, expression level of many genes implicated in Huntington's disease signaling, were changed.
Laws, Contingencies, Irreversible Divergence, and Physical Geography*

Abstract Four critical challenges for physical geography are examined here: deterioration of common cores of knowledge associated with increasing intellectual niche specialization; the need for conceptual thinking and problem-framing to catch up with measurement and analysis technology; and the need to explicitly incorporate human decision making in analysis of earth surface systems. The future calls for physical geography to embrace and confront the creative tension between nomothetic and interpretive science, and to fruitfully and explicitly integrate these approaches.
Alternative Screening Approaches for Discovery of Middle East Respiratory Syndrome Coronavirus Inhibitors

ABSTRACT Two coronaviruses causing severe respiratory disease and high mortality rates emerging within the past dozen years reinforces the need for clinically efficacious antivirals targeting coronaviruses. Alternative screening approaches for antivirals against the recently emergent Middle East respiratory syndrome coronavirus (MERS-CoV) may provide lead compounds to address this need. Two Antimicrobial Agents and Chemotherapy (AAC) papers screened libraries of approved compounds that may potentially be repurposed as MERS-CoV antivirals. A third AAC paper showed that a previously described severe acute respiratory syndrome coronavirus (SARS-CoV) helicase inhibitor also has activity against MERS-CoV.
Doctors’ and nurses’ views and experience of transferring patients from critical care home to die: A qualitative exploratory study

Background: Dying patients would prefer to die at home, and therefore a goal of end-of-life care is to offer choice regarding where patients die. However, whether it is feasible to offer this option to patients within critical care units and whether teams are willing to consider this option has gained limited exploration internationally. Aim: To examine current experiences of, practices in and views towards transferring patients in critical care settings home to die. Design: Exploratory two-stage qualitative study Setting/participants: Six focus groups were held with doctors and nurses from four intensive care units across two large hospital sites in England, general practitioners and community nurses from one community service in the south of England and members of a Patient and Public Forum. A further 15 nurses and 6 consultants from critical care units across the United Kingdom participated in follow-on telephone interviews. Findings: The practice of transferring critically ill patients home to die is a rare event in the United Kingdom, despite the positive view of health care professionals. Challenges to service provision include patient care needs, uncertain time to death and the view that transfer to community services is a complex, highly time-dependent undertaking. Conclusion: There are evidenced individual and policy drivers promoting high-quality care for all adults approaching the end of life encompassing preferred place of death. While there is evidence of this choice being honoured and delivered for some of the critical care population, it remains debatable whether this will become a conventional practice in end of life in this setting.
Aging and the Locus of the Global Precedence Effect: A Short Review and New Empirical Data

Precedence of the global over the local level in visual perception is well established by the use of compound, or hierarchical, stimuli. However, (a) virtually nothing is known concerning the fate of global precedence with normal aging, and (b) there is still a debate about the early versus late perceptual locus of the effect. The present study was planned to investigate both topics. Two experiments are reported where young adult and elderly subjects were enrolled for the recognition of compound letters either at the global or at the local level. In order to recruit late perceptual processes, the case of the letters varied in such a way that subjects had to activate graphemic codes to take their decision. It appeared that the global precedence effect was preserved. This observation shows an early perceptual source of the global precedence effect, which is then transferred to later stages of information processing. Age did not affect the global precedence phenomenon.