Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Boesenbergia rotunda (L.) Mansf. on sexual behaviour of male rats.

AIM To study the effects of Boesenbergia rotunda (Krachai) on sexual behaviour in male albino rats. METHODS Thirty-two male Wistar rats were equally divided into four groups: experimental groups were gavaged with the ethanolic extract of the rhizome of B. rotunda at doses of 60, 120 and 240 mg/kg and a control group received distilled water, for 60 days. Sexual behaviour, reproductive organs, diameter of seminiferous tubule, epididymal sperm density, and androgenic hormones were evaluated. RESULTS Within 30-min observation, there was no significant difference of courtship behaviour, mount frequency (MF), intromission frequency (IF), mount latency (ML), intromission latency (IL), copulatory efficiency or intercopulatory interval in male rats. In three 10-min intervals over a 30-min period, courtship behaviour and MF during the first 10-min were significantly higher than those in the second and third 10-min observation in all groups, whereas IF had no significant difference. All doses of B. rotunda extract significantly increased the relative testicular weight and the diameter of the seminiferous tubules. The dose of 60 mg/kg also significantly increased the relative weight of the seminal vesicle. Nevertheless, the sperm density, serum testosterone and androstenedione levels were not affected by the B. rotunda extract. CONCLUSION B. rotunda does not affect sexual behaviour nor serum androgenic levels.
Resection of parietal lobe gliomas: incidence and evolution of neurological deficits in 28 consecutive patients correlated to the location and morphological characteristics of the tumor.

OBJECT The goal of this study is to report the incidence and clinical evolution of neurological deficits in patients who underwent resection of gliomas confined to the parietal lobe. METHODS Patient demographics, findings of serial neurological examinations, tumor location and neuroimaging characteristics, extent of resection, and surgical outcomes were tabulated by reviewing inpatient and office records, as well as all pre- and postoperative magnetic resonance (MR) images obtained in 28 consecutive patients who underwent resection of a glial neoplasm found on imaging studies to be confined to the parietal lobe. Neurological deficits were correlated with hemispheric dominance, location of the lesion within the superior or inferior parietal lobules, subcortical extension, and involvement of the postcentral gyrus. The tumors were located in the dominant hemisphere in 18 patients (64%); had a mean diameter of 39 mm (range 14-69 mm); were isolated to the superior parietal lobule in six patients (21%) and to the inferior parietal lobule in eight patients (29%); and involved both lobules in 14 patients (50%). Gross-total resection, documented by MR imaging, was achieved in 24 patients (86%). Postoperatively, nine patients (32%) experienced new neurological deficits, whereas seven (25%) had an improvement in their preoperative deficit. A correlation was noted between larger tumors and the presence of neurological deficits both before and after resection. Postoperatively higher-level (association) parietal deficits were noted only in patients with tumors involving both the superior and inferior parietal lobules in the dominant hemisphere. At the 3-month follow-up examination, five of nine new postoperative deficits had resolved. CONCLUSIONS Neurological deterioration and improvement occur after resection of parietal lobe gliomas. Parietal lobe association deficits, specifically the components of Gerstmann syndrome, are mostly associated with large tumors that involve both the superior and inferior parietal lobules of the dominant hemisphere. New hemineglect or sensory extinction was not noted in any patient following resection of lesions located in the nondominant hemisphere. Nevertheless, primary parietal lobe deficits (for example, a visual field loss or cortical sensory syndrome) occurred in patients regardless of hemispheric dominance.
A 1.8-V 67-mW 10-bit 100-MS/s pipelined ADC using time-shifted CDS technique

A time-shifted correlated double sampling (CDS) technique is proposed in the design of a 10-bit 100-MS/s pipelined ADC. This technique significantly reduces the finite opamp gain error without compromising the conversion speed, allowing the active opamp blocks to be replaced by simple cascoded CMOS inverters. Both high-speed and low-power operation is achieved without compromising the accuracy requirement. An efficient common-mode voltage control is introduced for pseudodifferential architecture which can further reduce power consumption. Fabricated in a 0.18-/spl mu/m CMOS process, the prototype 10-bit pipelined ADC occupies 2.5 mm/sup 2/ of active die area. With 1-MHz input signal, it achieves 65-dB SFDR and 54-dB SNDR at 100MS/s. For 99-MHz input signal, the SFDR and SNDR are 63 and 51 dB, respectively. The total power consumption is 67 mW at 1.8-V supply, of which analog portion consumes 45 mW without any opamp current scaling down the pipeline.
Effects of L-Dopa and Dopamine D2 Agonists on Recollection and Familiarity in Idiopathic Nondementing Parkinson’s Disease

Idiopathic nondementing Parkinson’s disease (PD) is marked by progressive loss of dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area. Recent brain imaging work implicates these structures in dopamine modulated networks subserving episodic memory. These findings are of relevance to PD because they suggest that dopamine depletion contributes to the disease-dependent decline in episodic memory, and therefore, this decline should, at least partially, be remediated by dopaminergic medication. Recognition memory (RM), recollection and familiarity during recognition was examined in 17 PD patients, 12 of whom were medicated with a D2 dopamine agonist (pramipexole or ropinirole) and l-dopa, with a further 5 PD control patients on l-dopa but no D2 agonist. Memory was tested “ON” and, following a period of medication withdrawal, “OFF” and compared to a group of 14 matched healthy volunteers (HV). The HVs were also tested twice in the absence of medication. The patients on the agonists PD showed significant impairments in recollection ON- and OFF-medication, whereas the l-dopa control patients exhibited a decline in OFF-recollection only. RM and familiarity were spared in both groups ON- and OFF-medication. These findings suggest that D2 dopamine agonists (combined with l-dopa) contribute to disease-dependent episodic memory impairment.
The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/KATP Signaling Pathway

Plumeria rubra (Apocynaceae) is frequently used in folk medicine for the treatment of gastrointestinal disorders, hepatitis, and tracheitis, among other infirmities. The aim of this study was to investigate the gastroprotective potential of a protein fraction isolated from the latex of Plumeria rubra (PrLP) against ethanol-induced gastric lesions and describe the underlying mechanisms. In a dose-dependent manner, the pretreatment with PrLP prevented ethanol-induced gastric lesions in mice after single intravenous administration. The gastroprotective mechanism of PrLP was associated with the involvement of prostaglandins and balance of oxidant/antioxidant factors. Secondarily, the NO/cGMP/KATP pathway and activation of capsaicin-sensitive primary afferents were also demonstrated as part of the mechanism. This study shows that proteins extracted from the latex of P. rubra prevent gastric lesions induced in experimental animals. Also, the results support the use of the plant in folk medicine.
Cytoplasmic Accumulation of Sequestosome 1 (p62) Is a Predictor of Biochemical Recurrence, Rapid Tumor Cell Proliferation, and Genomic Instability in Prostate Cancer

Purpose: Sequestosome 1 (p62) is a multifunctional adapter protein accumulating in autophagy-defective cells. Experimental Design: To evaluate the clinical impact and relationship with key genomic alterations in prostate cancer, p62 protein levels were analyzed by immunohistochemistry on a tissue microarray containing 12,427 prostate cancers. Data on ERG status and deletions of PTEN, 3p13, 5q21, and 6q15 were available from earlier studies. Results: p62 immunostaining was absent in benign prostatic glands but present in 73% of 7,822 interpretable prostate cancers. Strong cytoplasmic p62 staining was tightly linked to high Gleason grade, advanced pathologic tumor (pT) stage, positive nodal status, positive resection margin, and early PSA recurrence (P < 0.0001 each). Increased levels of p62 were significantly linked to TMPRSS2–ERG fusions, both by FISH and immunohistochemical analysis (P < 0.0001 each). For example, moderate or strong p62 immunostaining was seen in 28.5% of cancers with TMPRSS2–ERG fusion detected by FISH and in 23.1% of cancers without such rearrangements (P < 0.0001). Strong p62 staining was significantly linked to the presence of all tested deletions, including PTEN (P < 0.0001), 6q15 (P < 0.0001), 5q21 (P = 0.0002), 3p13 (P = 0.0088), and 6q15 (P < 0.0001), suggesting a link between p62 accumulation and loss of genomic stability. The prognostic role of p62 protein accumulation was striking and independent of Gleason grade, pT stage, pN stage, surgical margin status, and preoperative PSA, regardless of whether preoperative or postoperative parameters were used for modeling. Conclusions: Our study identifies cytoplasmic accumulation of p62 as a strong predictor of an adverse prognostic behavior of prostate cancer independently from established clinicopathologic findings. Clin Cancer Res; 21(15); 3471–9. ©2015 AACR.
Sensitive Period of Auditory Perception and Linguistic Discrimination

The purpose of this study is to scientifically examine Kuhl’s (2011), originally Johnson and Newport’s (1989) critical period graph, from a perspective of auditory perception and linguistic discrimination. This study utilizes two types of experiments (auditory perception and linguistic phoneme discrimination) with five different age groups (5 years, 6-8 years, 9-13 years, 15-17 years, and 20-26 years) of Korean English learners. Auditory perception is examined via ultrasonic sounds that are commonly used in the medical field. In addition, each group is measured in terms of their ability to discriminate minimal pairs in Chinese. Since almost all Korean students already have some amount of English exposure, the researchers selected phonemes in Chinese, an unexposed foreign language for all of the subject groups. The results are almost completely in accordance with Kuhl’s critical period graph for auditory perception and linguistic discrimination; a sensitive age is found at 8. The results show that the auditory capability of kindergarten children is significantly better than that of other students, measured by their ability to perceive ultrasonic sounds and to distinguish ten minimal pairs in Chinese. This finding strongly implies that human auditory ability is a key factor for the sensitive period of language acquisition.
In planta changes in protein phosphorylation induced by the plant hormone abscisic acid

Abscisic acid (ABA) is a hormone that controls seed dormancy and germination as well as the overall plant response to important environmental stresses such as drought. Recent studies have demonstrated that the ABA-bound receptor binds to and inhibits a class of protein phosphatases. To identify more broadly the phosphoproteins affected by this hormone in vivo, we used 14N/15N metabolic labeling to perform a quantitative untargeted mass spectrometric analysis of the Arabidopsis thaliana phosphoproteome following ABA treatment. We found that 50 different phosphopeptides had their phosphorylation state significantly altered by ABA over a treatment period lasting 5–30 min. Among these changes were increases in phosphorylation of subfamily 2 SNF1-related kinases and ABA-responsive basic leucine zipper transcription factors implicated in ABA signaling by previous in vitro studies. Furthermore, four members of the aquaporin family showed decreased phosphorylation at a carboxy-terminal serine which is predicted to cause closure of the water-transporting aquaporin gate, consistent with ABA's role in ameliorating the effect of drought. Finally, more than 20 proteins not previously known to be involved with ABA were found to have significantly altered phosphorylation levels. Many of these changes are phosphorylation decreases, indicating that an expanded model of ABA signaling, beyond simple phosphatase inhibition, may be necessary. This quantitative proteomics dataset provides a more comprehensive, albeit incomplete, view both of the protein targets whose biochemical activities are likely to be controlled by ABA and of the nature of the emerging phosphorylation and dephosphorylation cascades triggered by this hormone.
School Enrollment Impacts of Non-traditional Household Structure (cid:3)

Children growing up away from their biological parents may experience lower human capital investment. This paper measures the impact of child fostering on school enrollment using (cid:133)xed e⁄ects regressions to address the endogeneity of fostering. Data collection by the author involved tracking and interviewing the sending and receiving household participating in each fostering exchange, allowing a comparison of foster children with their non-fostered biological siblings. Young foster children are 17.5 and 17.9 percent more likely to be enrolled after fostering than their host and biological siblings, respectively. This schooling improvement translates into a long-run improvement in educational and occupational attainment. employment more than
Enjoyment in zoos

Zoo visits are often described as fun outings by adults and family visitors alike, yet previous research into motivations, benefits and satisfaction with such outings has yet to describe what aspects of these experiences are sources of enjoyment. This paper reports results from a study that investigated how adult visitors define enjoyment in zoo experiences. Q methodology was used in order to address the inherent subjectivity of personal enjoyment because it allowed the participants to construct unique, personal meaning, while quantitatively comparing these constructed narratives to one another. Four distinct, socially held perspectives of what enjoyment means to visitors emerged in the analysis. Each of these perspectives represented a unique combination of factors that provide new insight into how adult visitors evaluate their personal enjoyment while at the zoo. The authors conclude that these findings offer zoo managers new information by which to assess their programme offerings and satisfaction measures.
LTE UL Power Control for the Improvement of LTE/Wi-Fi Coexistence

Spectrum sharing is a powerful alternative to deal with the exponential increase on the wireless communication capacity demand. In this context, the coexistence of two of the most prominent wireless technologies today, Long Term Evolution (LTE) and Wi-Fi, is an important research topic. In the most common Wi-Fi network operation, the Distributed Coordination Function (DCF), communication nodes access the channel only if the interference level is below a certain threshold. Then, Wi-Fi operation is severely affected when in coexistence with LTE. This paper proposes the use of LTE uplink (UL) power control to improve LTE/Wi-Fi coexistence. With the introduction of an additional factor to the conventional LTE UL power control, a controlled decrease of LTE UL transmit powers is carried out according to interference measurements, giving opportunity to Wi-Fi transmissions. The proposed LTE UL power control with interference aware power operating point is a flexible tool to deal with the trade-off between LTE and Wi-Fi performances in coexistence, since it is able to set different LTE/Wi-Fi coexistence configurations with the choice of a single parameter. Simulation results show that the proposed approach can provide similar or better performance for both LTE and Wi-Fi networks than a previously proposed interference avoidance mechanism.
Scippa: system-centric IPC provenance on Android

Google's Android OS provides a lightweight IPC mechanism called Binder, which enables the development of feature-rich apps that seamlessly integrate services and data of other apps. Whenever apps can act both as service consumers and service providers, it is inevitable that the IPC mechanism provides message receivers with message provenance information to establish trust. However, the Android OS currently fails in providing sufficient provenance information, which has led to a number of attacks. We present an extension to the Android IPC mechanism, called Scippa, that establishes IPC call-chains across application processes. Scippa provides provenance information required to effectively prevent recent attacks such as confused deputy attacks. Our solution constitutes a system-centric approach that extends the Binder kernel module and Android's message handlers. Scippa integrates seamlessly into the system architecture and our evaluation shows a performance overhead of only 2.23% on Android OS v4.2. 2.
Career as a Project of the Self and Labour Process Discipline

This paper draws together recent insights in labour process analysis, which highlight the role of Panoptic techniques of disciplinary power, and work which suggests that the project of self-management has become a defining feature of contemporary subjectivity. In particular, it is argued that the discipline operationalised within the discursive and non-discursive practices of `career' should be treated as an aspect of this contemporary project of self-management. The pursuit of career is seen to have the potential to transform techniques of disciplinary power into adjuncts of these projects of the self. These themes are explored through the presentation of case study material on the accounting labour process.
Structures of mono-unsaturated triacylglycerols. II. The β2 polymorph

The crystal structures of the β1 polymorphs of mono-unsaturated triacylglycerols have been solved from high-resolution laboratory and synchrotron powder diffraction data for five pure compounds, the 1,3-dimyristoyl-2-oleoylglycerol (β1-MOM), 1,3-dipalmitoyl-2-oleoylglycerol (β1-POP), 1,3-distearoyl-2-oleoylglycerol (β1-SOS), 1-palmitoyl-2-oleoyl-3-stearoylglycerol (β1-POS), 1-stearoyl-2-oleoyl-3-arachidoylglycerol (β1-SOA) and three mixtures: the co-crystallized 1:1 molar mixture of SOS and POP [β1-SOS/POP (1:1)] and two cocoa butters from Bahia and Ivory Coast, both in their β-VI (= β1) polymorph. All eight β1 structures crystallized in the space group (P21/n) and have two short cell axes (5.44–5.46 and 8.18–8.22 A), as well as a very long b axis (112–135 A). The dominant-zone problem in the indexing of the powder patterns was solved with the special brute-force indexing routine LSQDETC from the POWSIM program. Structures were solved using the direct-space parallel-tempering method FOX and refined with GSAS. Along the b axis, alternations of inversion-centre-related `three-packs' can be discerned. Each `three-pack' has a central oleic zone, with oleic acyl chains of the molecules being packed together, that is sandwiched between two saturated-chain zones. The conformation of the triacylglycerol molecules is relatively `flat' because the least-square planes through the saturated chains and those through the saturated parts of the olein chain are parallel. The solution of the β1 structures is a step forward towards understanding the mechanism of fat-bloom formation in dark chocolate and has led to a reexamination of the β2 structural model [see van Mechelen et al. (2006). Acta Cryst. B62, 1131–1138].
The burden of bladder cancer care: direct and indirect costs

Purpose of review Bladder cancer is a common, complex, and costly disease. Every year in the USA, bladder cancer is responsible for 70 000 diagnosed cases and over 15 000 deaths. Once diagnosed, patients with nonmuscle invasive bladder cancer (NMIBC) are committed to a lifetime of invasive procedures and potential hospitalizations that result in substantial direct and indirect costs. Recent findings Bladder cancer is the most costly cancer among the elderly, estimated at nearly $4 billion per year, and has the highest cost of any cancer when categorized on a per patient basis. The direct economic cost of NMIBC is fueled by the need for lifelong cystoscopic examination and variations in treatment algorithms. This fiscal burden is further compounded by the indirect impact on psychological health and quality of life of patients and their families. Despite the development of new technologies, such as novel urinary biomarkers and innovative cystoscopic methods, no alternative to cystoscopic surveillance has been established. Summary The management of patients with NMIBC is responsible for a substantial financial burden with indirect costs that extend beyond quantifiable direct costs.
Is the Use of Sexual and Fear Appeals Ethical? A Moral Evaluation by Generation Y College Students

Abstract This study offers insights into the ethical beliefs of Generation Y, particularly as it guides members' evaluations of sex appeals and fear appeals in advertising. Results show that moral philosophy plays a significant role in evaluating sex appeals but not so for fear appeals. Furthermore, the gender of the respondent is a factor that can take precedence over moral evaluations when sex appeals are present. Implications for advertisers and opportunities for further research are explored.
Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats

Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.
Semantic Role Labeling via Instance-Based Learning

This paper demonstrates two methods to improve the performance of instance-based learning (IBL) algorithms for the problem of Semantic Role Labeling (SRL). Two IBL algorithms are utilized: k-Nearest Neighbor (kNN), and Priority Maximum Likelihood (PML) with a modified back-off combination method. The experimental data are the WSJ23 and Brown Corpus test sets from the CoNLL-2005 Shared Task. It is shown that applying the Tree-Based Predicate-Argument Recognition Algorithm (PARA) to the data as a preprocessing stage allows kNN and PML to deliver F1: 68.61 and 71.02 respectively on the WSJ23, and F1: 56.96 and 60.55 on the Brown Corpus; an increase of 8.28 in F1 measurement over the most recent published PML results for this problem (Palmer et al., 2005). Training times for IBL algorithms are very much faster than for other widely used techniques for SRL (e.g. parsing, support vector machines, perceptrons, etc); and the feature reduction effects of PARA yield testing and processing speeds of around 1.0 second per sentence for kNN and 0.9 second per sentence for PML respectively, suggesting that IBL could be a more practical way to perform SRL for NLP applications where it is employed; such as realtime Machine Translation or Automatic Speech Recognition.