Miracle-dz/UniFAR-FTUs huggingface dataset:
Till Surgery do us Part: Unexpected Bilateral Kissing Molars

The occurrence impacted teeth, single or multiple is very common. But, phenomenon of kissing molars is an extremely rare phenomenon. Mandibular third molars are the most common impacted teeth. Mandibular first or second molars does not share the same frequency of occurrence. But, there are rare cases in which the occlusal surfaces of impacted molars are united by the same follicular space and the roots point in the opposite direction, and are termed as kissing molars. Sometimes, these teeth will be associated with pathologies. This article reports a rare case of mandibular bilateral kissing molars.
Inactivation of Rb Function and Induction of Proliferation Involves Cyclin E-Mediated HLA Class I-Mediated Induction of Cell

Chronic rejection of transplanted organs is manifested as atherosclerosis of the blood vessels of the allograft. HLA class I Ags have been implicated to play a major role in this process, since signaling via HLA class I molecules can induce the proliferation of aortic endothelial as well as smooth muscle cells. In this study, we show that HLA class I-mediated induction of cell proliferation correlates with inactivation of the Rb protein in the T cell line Jurkat as well as human aortic endothelial cells. HLA class I-mediated inactivation of Rb can be inhibited speciﬁcally by neutralizing Abs to basic ﬁbroblast growth factor (bFGF), suggesting a role for FGF receptors in the signaling process. Signaling through HLA class I molecules induced cyclin E-associated kinase activity withi n 4 h inquiescent endothelial cells, and appeared to mediate the inactivation of Rb. A cdk2 inhibitor, Olomoucine, as well as a dominant-negative cdk2 construct prevented HLA class I-mediated inactivation of Rb; in contrast, dominant-negative cdk4 and cdk6 constructs had no effect. Furthermore, there was no increase in cyclin D-associated kinase activity upon HLA class I ligation, suggesting that cyclin E-dependent kinase activity mediates Rb inactivation, leading to E2F activation and cell proliferation. The Journal of Immunology, 1999, 162: 5351–5358.
Convergence of functionals of sums of r.v.s to local times of fractional stable motions

Consider a sequence Xk = ∑j=0∞cjξk−j, k ≥ 1, where cj, j ≥ 0, is a sequence of constants and ξj, −∞ < j < ∞, is a sequence of independent identically distributed (i.i.d.) random variables (r.v.s) belonging to the domain of attraction of a strictly stable law with index 0<α≤2. Let Sk = ∑j = 1kXj. Under suitable conditions on the constants cj it is known that for a suitable normalizing constant γn, the partial sum process γn−1S[nt] converges in distribution to a linear fractional stable motion (indexed by α and H, 0 < H < 1). A fractional ARIMA process with possibly heavy tailed innovations is a special case of the process Xk. In this paper it is established that the process n−1βn∑k = 1[nt]f(βn(γn−1Sk+x)) converges in distribution to ( ∫−∞∞f( y) dy)L(t,−x), where L(t,x) is the local time of the linear fractional stable motion, for a wide class of functions f( y) that includes the indicator functions of bounded intervals of the real line. Here βn→∞ such that n−1βn→0. The only further condition that is assumed on the distribution of ξ1 is that either it satisfies the Cramer’s condition or has a nonzero absolutely continuous component. The results have motivation in large sample inference for certain nonlinear time series models.
Attitudes to Cardiopulmonary Resuscitation by Nigerian Practising Professional and Student Teachers Compared

Background: There is an understandably global trend to have bystander cardiopulmonary resuscitation (CPR) training encouraged in schools and many countries of the world especially the developed nations are complying but the situation is different in Nigeria. School teachers are expected to play central role in the success of this programme. This study aimed at comparing the attitude of Nigerian practising professional teachers and the undergraduate student (upcoming) teachers. Methods: A quasi-experimental study involving two cohorts (practising professional teachers and undergraduate student teachers) of forty-one (41) participants each was carried out. Their pre-training and post-training attitudes of both groups were assessed using the same self-administered questionnaire. The data was analysed using SPSS and tested statistically using both descriptive statistics of percentages, means with standard deviations and paired sample T-test for the null hypotheses while significance level was set at P 0.05). Conclusion: The practising professional teachers and the student teachers have statistically significantly similar positive attitudes to CPR before and after the training. This is considered a very positive finding for the future of bystander CPR training and provision in Nigerian schools system and ultimately the general public.
Optimal factorial designs for cDNA microarray experiments

We consider cDNA microarray experiments when the cell populations have a factorial Structure, and investigate the problem of their optimal designing under a baseline parametrization where the objects of interest differ from those under the more common orthogonal parametrization. First, analytical results are given for the 2 x 2 factorial. Since practical applications often involve a more complex factorial structure, we next explore general factorials and obtain a collection of optimal designs in the saturated, that is, most economic, case. This, in turn, is seen to yield an approach for finding optimal or efficient designs in the practically more important nearly saturated cases. Thereafter, the findings are extended to the more intricate situation where the underlying model incorporates dye-coloring effects, and the role of dye-swapping is critically examined.
Signature Strengths: A Positive Psychology Intervention with Informal Caregivers

The negative consequences of informal caregiving on caregivers’ physical and mental health are well-documented (Vitaliano, Zhang, & Scanlan, 2003; Pinquart & Sorensen, 2003a). Many evidence-based treatments exist to address caregiver distress and burden (Gallagher-Thompson & Coon, 2007). Positive aspects of caregiving have received considerably less attention in the literature and, at present, there are relatively few interventions that were designed with a primary focus on improving positive aspects of caregiving. The current study tested an established positive psychology intervention (Seligman, Steen, Park, & Peterson, 2005) with informal caregivers of older adults. This internet-based study employed a three group randomized controlled design. One hundred and fifty-five women caring for an older adult were randomly assigned to one of three conditions: a standard version of the exercise, a modified version of the exercise adapted for the caregiving domain, and a survey only control group. Results showed that participants reported significant increases in happiness, F (2, 174) = 3.54, p = . 04, ηp = . 04, 90% CI [. 002, . 089], and satisfaction with life F (2, 170) = 9.38, p <. 001, ηp= . 10, 90% CI [. 03, . 17]. The observed improvements in well-being were similar across all conditions. Participants in the intervention conditions showed a significant decrease in depressive symptoms compared to the control group, but this effect was only seen at onemonth follow-up, F (1, 88) = 4.44, p = . 04, ηp= . 05, 90% CI [. 00, . 14]. Participants who received the modified version of the exercise did not show significantly better performance on positive caregiving measures in relation to participants who received the standard version or survey only. Although, secondary analyses revealed the modified condition had significant increases in positive aspects of caregiving at one-month followCAREGIVER STRENGTHS INTERVENTION 3 up compared to their baseline scores, t (29)= -2.34, p = . 03, d = -. 36, 95% CI [. 06, . 79]. In summary, caregivers showed improved well-being over the course of the study. However, results were mixed with regard to clear intervention effects, and there was a lack of evidence demonstrating that improved well-being, mental health, and positive caregiving outcomes were directly attributable to the intervention and not other factors.
Implicit Language Attitudes Toward Historically White Accents in the South African Context

This study explores the use of Implicit Association Test as an effective research tool to investigate language attitudes in South Africa. We aim to show how Standard South African English and Afrikaans-accented English are cognitively managed by young L1 South African indigenous language speakers. Results corroborate (a) participants’ statistically significant negative attitudes toward Afrikaans-accented English speakers, (b) the indexical nature of accents in triggering language attitudes, and (c) a main effect of modality when processing visual versus audio inputs.
Diagnosis of Multiple Sclerosis ( MS ) Using Convolutional Neural Network ( CNN ) from MRIs

This paper presents a novel fully automated process of features extraction and classification of Multiple sclerosis (MS) daisies from magnetic resonance images (MRI). This hybrid method uses convolution neural network (CNN) for features extraction and a multilayer neural network for classification two classes normal and MS. The convolution neural network for recognition of Multiple sclerosis is considered in this paper showed that CNN has strong potential for detection of MS. The process of feature extraction form flair MRI is done by using CNN increases the performance of recognition. CNN due to lack of sensitivity to noise is good for performance diagnosis. Our result shows that CNN provides high detection rates without using any lesion segmentation. This fully automated method produces reliable MRI analysis and classification while is considering variability.
FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells

The transcription factor Forkhead box M1 (FOXM1) is a key regulator of cell proliferation and is overexpressed in many forms of primary cancers, leading to uncontrolled cell division and genomic instability. To address the role of FOXM1 in chemoresistance, we generated a cisplatin-resistant breast cancer cell line (MCF-7-CISR), which had an elevated level of FOXM1 protein and mRNA expression relative to the parental MCF-7 cells. A close correlation was observed between FOXM1 and the expression of its proposed downstream targets that are involved in DNA repair; breast cancer–associated gene 2 (BRCA2) and X-ray cross-complementing group 1 (XRCC1) were expressed at higher levels in the resistant cell lines compared with the sensitive MCF-7 cells. Moreover, cisplatin treatment induced DNA damage repair in MCF-7-CISR and not in MCF-7 cells. Furthermore, the expression of a constitutively active FOXM1 (ΔN-FOXM1) in MCF-7 cells alone was sufficient to confer cisplatin resistance. Crucially, the impairment of DNA damage repair pathways through the small interfering RNA knockdown inhibition of either FOXM1 or BRCA2/XRCC1 showed that only the silencing of FOXM1 could significantly reduce the rate of proliferation in response to cisplatin treatment in the resistant cells. This suggests that the targeting of FOXM1 is a viable strategy in circumventing acquired cisplatin resistance. Consistently, the FOXM1 inhibitor thiostrepton also showed efficacy in causing cell death and proliferative arrest in the cisplatin-resistant cells through the downregulation of FOXM1 expression. Taken together, we have identified a novel mechanism of acquired cisplatin resistance in breast cancer cells through the induction of FOXM1. Mol Cancer Res; 8(1); 24–34
Vorinostat-Induced Apoptosis in Mantle Cell Lymphoma Is Mediated by Acetylation of Proapoptotic BH3-Only Gene Promoters

Purpose: Mantle cell lymphoma (MCL) is an aggressive B-cell neoplasm with generally poor prognosis, for which current therapies have shown limited efficacy. Vorinostat is a histone deacetylase inhibitor (HDACi) that has been approved for the treatment of cutaneous T-cell lymphoma. Our purpose was to describe the molecular mechanism whereby vorinostat induces apoptosis in MCL with particular emphasis on the role of proapoptotic BH3-only proteins. Experimental Design: The sensitivity to vorinostat was analyzed in eight MCL cell lines and primary cells from 10 MCL patients. Determination of vorinostat mechanism of action was done by flow cytometry, immunoblotting, HDAC activity assay kit, quantitative reverse transcription PCR, chromatin immunoprecipitation, and siRNA-mediated transfection. Results: Vorinostat inhibited total histone deacetylase activity leading to selective toxicity toward tumor cells. Vorinostat-mediated cell death implied the activation of mitochondrial apoptosis, as attested by BAX and BAK conformational changes, mitochondrial depolarization, reactive oxygen species generation, and subsequent caspase-dependent cell death. This phenomenon was linked to H4 hyperacetylation on promoter regions and consequent transcriptional activation of the proapoptotic BH3-only genes BIM, BMF, and NOXA. Selective knockdown of the three corresponding proteins rescued cells from vorinostat-induced apoptosis. Moreover, vorinostat enhanced the activity of the BH3-mimetic ABT-263 in MCL cells, leading to synergistic apoptosis induction. Conclusion: These results indicated that transcriptional upregulation of BH3-only proteins plays an important role in the antitumoral activity of vorinostat in MCL, and that HDACi alone or in combination with BH3-mimetizing agents may represent a promising therapeutic approach for MCL patients. Clin Cancer Res; 17(12); 3956–68. ©2011 AACR.
Sensitivity of Global Translation to mTOR Inhibition in REN Cells Depends on the Equilibrium between eIF4E and 4E-BP1

Initiation is the rate-limiting phase of protein synthesis, controlled by signaling pathways regulating the phosphorylation of translation factors. Initiation has three steps, 43S, 48S and 80S formation. 43S formation is repressed by eIF2α phosphorylation. The subsequent steps, 48S and 80S formation are enabled by growth factors. 48S relies on eIF4E-mediated assembly of eIF4F complex; 4E-BPs competitively displace eIF4E from eIF4F. Two pathways control eIF4F: 1) mTORc1 phosphorylates and inactivates 4E-BPs, leading to eIF4F formation; 2) the Ras-Mnk cascade phosphorylates eIF4E. We show that REN and NCI-H28 mesothelioma cells have constitutive activation of both pathways and maximal translation rate, in the absence of exogenous growth factors. Translation is rapidly abrogated by phosphorylation of eIF2α. Surprisingly, pharmacological inhibition of mTORc1 leads to the complete dephosphorylation of downstream targets, without changes in methionine incorporation. In addition, the combined administration of mTORc1 and MAPK/Mnk inhibitors has no additive effect. The inhibition of both mTORc1 and mTORc2 does not affect the metabolic rate. In spite of this, mTORc1 inhibition reduces eIF4F complex formation, and depresses translocation of TOP mRNAs on polysomes. Downregulation of eIF4E and overexpression of 4E-BP1 induce rapamycin sensitivity, suggesting that disruption of eIF4F complex, due to eIF4E modulation, competes with its recycling to ribosomes. These data suggest the existence of a dynamic equilibrium in which eIF4F is not essential for all mRNAs and is not displaced from translated mRNAs, before recycling to the next.
The role of apathy, personal insecurity, and socio-economic status in formation of risk-taking behavior among university students

ABSTRACT The primary purpose of the current study was to explore the role of apathy and personal insecurity in risk-taking behavior among university students. Furthermore, it examined the influence of socio-economic factors (such as age, gender, and education) on risk-taking behavior. For this purpose, 882 university students elicited their responses through self-structured questionnaire. Factor analysis and reliability analysis were applied to test the reliability, validity, and robustness of scales. Bivariate analysis was used to test hypothesis, independent T-test was used to examine the differences in categories of risk-taking behavior, and multiple linear regression was used to scrutinize model fit. There was association between apathy, personal insecurity, socio-economic characteristics (such as gender, education, and father education) and risk-taking behavior of the university students. The current study would add to empirical foundation to build a theoretical framework of risk-taking behavior based on education, age, income, and residential background. This study contributes to the academic scholarship by explaining individual differences based on socio-economic status in prediction of risk-taking behavior. Furthermore, it provides a different theoretical insight and logical explanation of risk-taking propensity for constructs of apathy and personal insecurity. To the best knowledge of the researchers, it is first study to explain the association apathy, personal insecurity and risk-taking behavior through quantification of data among resourceful group of youth.
The Impact of Hyper-components Design on Web Usefulness and Ease of Use

The structure and formal organization of a hypermedia design are critical to the effectiveness of the navigation process. Both nodes and hyperlinks often referred, as “hyper-components” are basic building blocks of hypermedia. Effective use of these components facilitates appropriate organization of data and efficient navigation. This study explores the impact of the number of hyperlinks and node size on user’s perceived ease of use and perceived usefulness of websites. Results suggest that websites designed with many hyperlinks and small node size yield the highest positive users' perceptions. Theories of reasoned action and self-efficacy are the framework for the proposed model. Implications for navigation processes and web designs are discussed.
Cytotoxicity Study of Nigella Sativa and Zingiber zerumbet Extracts,Thymoquinone and Zerumbone Isolated on Human Myeloid Leukemia(HL60) Cell

The cytotoxicity effects of Nigella sativa (Ns) and Zingiber zerumbet (Zz) extracts on acute Human myeloid leukemia cell line (HL60) are reported. The HL60 cell line was purchased from the American Tissue Culture Company (ATCC) was treated with petroleum ether (PE) and aqueous (AQ) extracts of Ns and Zz extracts of ethanol (ET) and Hexane (HEX). In an attempt to explain cytotoxicity effects of Ns and Zz extracts by 3-(4,5-dimethylthizol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay, we examined the effects of Doxorubin (Dox) on their sensitivity as anticancer drugs which was assigns as a positive control in this experiment. Different plant species has different component as bioactive compound. The different activity is present by the different compound. The cytotoxicity effects of plant species are differed based on the presence of their bioactive compound. Therefore, this study was carried out to compare the cytotoxicity effects of Nigella sativa (Ns) and Zingiber zerumbet (Zz) extracts on HL60 cell lines since both of these plants are from different species. Furthermore, this study was also to compare the cytotoxicity effect of plant extract and its compound which are Ns extract and thymoquinone, Zz extract and zerumbone. In this study, Hexane extract of Zz significantly dropped off the percentage of cell viability of HL60 cell by giving the lowest IC 50 value which is 63.72ug/ml (p<0.05). Hexane extracts is more effective solvent compared to ethanol that gave IC 50 value of 345.3ug/ml. Ns extract is less effective on HL60 cell lines that gives the highest IC 50 value which are 654ug/ml for PE and greater than 1000ug/ml for AQ. It is concluded that the cytotoxicity effects of Zz is more proficient as compared to Ns in this cell. HEX extract is more appropriate solvent for the Zz extraction that gave the lowest IC 50 as compared to ET. In addition, PE extract shows the characteristic of more appropriate solvent for Ns extraction compared to AQ solvent since gives the lowest IC 50 value. On the other hand, both of plant species showed apoptosis as mode of cell death.
CMOS implementation of a new high speed, glitch-free 5-2 compressor for fast arithmetic operations

This paper presents a new high speed, low power 5-2 compressor which is constructed according to a sensible combination of pass transistor logics and static logics. The 5-2 compressor is designed based on a new truth table that is obtained by performing some changes on its conventional truth table. So simple structures are obtained in which capacitances of middle stages are decreased. Therefore, a reduction of power dissipation and a reduction of overall latency are achieved. Also, the input and internal driving problems have been decreased, considerably. Because of similar paths from inputs to the outputs, there will be no need for extra buffers in low latency paths to equalize the delays. Therefore, the power dissipation will be decreased and the output waveforms will be glitch-free. Furthermore, utilizing voltage full swing logics in these architectures has enhanced the speed of cascaded operations. The total latency and power dissipation of the proposed 5-2 compressor are about 302 ps and 248.62 μw, respectively, which is simulated by HSPICE using TSMC 0.18 μm CMOS technology.
A simple and efficient approach for coarse segmentation of Moroccan coastal upwelling

In this work, we aim to develop a simple and fast algorithm using conventional methods in images segmentation for the automatic detection and extraction of upwelling areas, in the coastal region of Morocco, from the sea surface temperature (SST) satellite images. Our approach is based on the evaluation and comparison between two unsupervised classification methods, Otsu and Fuzzy C-means, and explores the applicability of these methods to our classification problem. The latter consists in coarse detection of the main thermal front that separates coastal cold upwelling waters from the remaining ocean waters. The algorithm has been applied and validated by an oceanographer over a database of 66 SST images corresponding to southern Moroccan coastal upwelling of the years 2004, 2005, 2007 and 2009. The results indicate that the proposed algorithm revealed is promising and reliable on different upwelling scenarios and for a wide variety of oceanographic conditions.
The Inhibition of KCa3.1 Channels Activity Reduces Cell Motility in Glioblastoma Derived Cancer Stem Cells

In the present study we evaluated the expression of the intermediate conductance calcium-activated potassium (KCa3.1) channel in human glioblastoma stem-like cells (CSCs) and investigated its role in cell motility. While the KCa3.1 channel is not expressed in neuronal- and glial-derived tissues of healthy individuals, both the KCa3.1 mRNA and protein are present in the glioblastoma tumor population, and are significantly enhanced in CSCs derived from both established cell line U87MG and a primary cell line, FCN9. Consistent with these data, voltage-independent and TRAM-34 sensitive potassium currents imputable to the KCa3.1 channel were recorded in the murine GL261 cell line and several primary human glioblastoma cells lines. Moreover, a significantly higher KCa3.1 current was recorded in U87MG-CD133 positive cells as compared to the U87MG-CD133 negative subpopulation. Further, we found that the tumor cell motility is strongly associated with KCa3.1 channel expression. Blockade of the KCa3.1 channel with the specific inhibitor TRAM-34 has in fact a greater impact on the motility of CSCs (reduction of 75%), which express a high level of KCa3.1 channel, than on the FCN9 parental population (reduction of 32%), where the KCa3.1 channel is expressed at lower level. Similar results were also observed with the CSCs derived from U87MG. Because invasion of surrounding tissues is one of the main causes of treatment failure in glioblastoma, these findings can be relevant for future development of novel cancer therapeutic drugs.