Miracle-dz/UniFAR-FTUs huggingface dataset:
A Spitzer Space Telescope Study of Disks in the Young σ Orionis Cluster

We report new Spitzer Space Telescope observations, using the IRAC and MIPS instruments, of the young (~3 Myr) σ Orionis cluster. We identify 336 stars as members of the cluster, using optical and near-infrared color-magnitude diagrams. Using the spectral energy distribution slopes in the IRAC spectral range, we place objects into several classes: non-excess stars, stars with optically thick disks (such as classical T Tauri stars), class I (protostellar) candidates, and stars with "evolved disks"; the last exhibit smaller IRAC excesses than optically thick disk systems. In general, this classification agrees with the location expected in IRAC-MIPS color-color diagrams for these objects. We find that the evolved disk systems are mostly a combination of objects with optically thick but nonflared disks, suggesting grain growth and/or settling, and transition disks, systems in which the inner disk is partially or fully cleared of small dust. In all, we identify seven transition disk candidates and three possible debris disk systems. As in other young stellar populations, the fraction of disks depends on the stellar mass, ranging from ~10% for stars in the Herbig Ae/Be mass range (>2 M☉) to ~35% for those in the T Tauri mass range (1-0.1 M☉). The IRAC infrared excesses found in stellar clusters and associations with and without central high-mass stars are similar, suggesting that external photoevaporation is not very important in many clusters. Finally, we find no correlation between the X-ray luminosity and the disk infrared excess, suggesting that the X-rays are not strongly affected by disk accretion.
Pregnancy and Delivery in Patients with Mastocytosis Treated at the Polish Center of the European Competence Network on Mastocytosis (ECNM)

Objective To present current guidelines regarding treatment of mastocytosis in pregnancy on the example of observed patients. Design Case control national study. Setting Polish Center of the European Competence Network on Mastocytosis (ECNM). Population or Sample 23 singleton spontaneous pregnancies in 17 women diagnosed with mastocytosis in years 1999–2014, before becoming pregnant. Methods Prospective analysis outcomes of pregnancies and deliveries. Main Outcome Measures Survey developed in cooperation with the Spanish Instituto de Estudios de Mastocitosis de Castilla-La Mancha (CLMast), Hospital Virgen del Valle, Toledo, Red Espańola de Mastocitosis (REMA), Spain. Results All 23 pregnancies resulted from natural conception. Obstetrical complications recorded in the first trimester included spontaneous miscarriage (5 pregnancies). Four patients delivered preterm, including one delivery due to preeclampsia at 26 weeks which resulted with neonate death due to extreme prematurity. Five women delivered via cesarean: four due to obstetrical indications and one due to mastocytosis, during which no anesthesia related complications were recorded. Of patients delivering vaginally, two received extradural anesthesia, three required oxytocin infusion due to uterine hypotonia. No labor complications were recorded. In one woman with pregnancy-induced hypertension, early puerperium was complicated by the presence of persistent arterial hypertension. One neonate was born with the signs of cutaneous mastocytosis. Another neonate was diagnosed with Patau syndrome. Four women were treated for mastocytosis prior to conception and continued therapy after becoming pregnant. One patient was put on medications in the first trimester due to worsening of her symptoms. Pregnancy exerted only a slight effect on the intensity and frequency of mastocytosis-related symptoms observed. Worsening of the disease-related symptoms was documented in only four patients (23%). None of the patients showed the signs of anaphylaxis, either before becoming pregnant, or during pregnancy and puerperium. Conclusions There is no contraindication to pregnancy when mastocystosis-related pathologies are under appropriate medical control.
An Observe-Model-Exercise* Paradigm to Test Event-Driven Systems with Undetermined Input Spaces

System testing of software applications with a graphical-user interface (GUI) front-end requires that sequences of GUI events, that sample the application's input space, be generated and executed as test cases on the GUI. However, the context-sensitive behavior of the GUI of most of today's non-trivial software applications makes it practically impossible to fully determine the software's input space. Consequently, GUI testers-both automated and manual-working with undetermined input spaces are, in some sense, blindly navigating the GUI, unknowingly missing allowable event sequences, and failing to realize that the GUI implementation may allow the execution of some disallowed sequences. In this paper, we develop a new paradigm for GUI testing, one that we call Observe-Model-Exercise* (OME*) to tackle the challenges of testing context-sensitive GUIs with undetermined input spaces. Starting with an incomplete model of the GUI's input space, a set of coverage elements to test, and test cases, OME* iteratively observes the existence of new events during execution of the test cases, expands the model of the GUI's input space, computes new coverage elements, and obtains new test cases to exercise the new elements. Our experiment with 8 open-source software subjects, more than 500,000 test cases running for almost 1,100 machine-days, shows that OME* is able to expand the test space on average by 464.11 percent; it detected 34 faults that had never been detected before.
Hate Crimes in Post-9/11 Pennsylvania

Extant research suggests that police involvement with hate crimes and bias incidents may be affected by case- and community-level characteristics. Triggering events, such as the terrorist attacks on September 11, 2001 (9/11), or the recent heated debates concerning illegal immigration, may also mediate this relationship. The present study builds on prior research by replicating the work of Wilson and Ruback (2003), which explored whether historical events, case characteristics, and community demographics are significantly associated with police involvement and response to bias-motivated offenses. The goals of this study were twofold: (1) to determine if the level of police response to bias-motivated incidents changed significantly post-9/11 and (2) to determine the extent to which case- and community-level factors are associated with police involvement. The findings illustrate that a significant increase in police response to hate crimes and bias incidents occurred post-9/11, and that both case- and community-level characteristics affect police involvement.
REFLECTIONS ON FREQUENCY EFFECTS IN LANGUAGE PROCESSING

This response addresses the following points raised in the commentaries: (a) complementary learning mechanisms, the distinction between explicit and implicit memory, and the neuroscience of “noticing”; (b) what must and what need not be noticed for learning; (c) when frequency fails to drive learning, which addresses factors such as failing to notice cues, perseveration, transfer from L1, developmental readiness, thinking too hard, pedagogical input, and practicing; (d) attention and form-focused instruction; (e) conscious and unconscious knowledge of frequency; (f) sequences of acquisition—from formula, through low-scope pattern, to construction; (g) the Fundamental Difference hypothesis; (h) the blind faith of categorical grammar; (i) Labovian variationist perspectives; (j) parsimony and theory testing; (k) universals and predispositions; and (l) wanna-contractions. It concludes by emphasizing that language acquisition is a process of dynamic emergence and that learners' language is a product of their history of usage in communicative interaction.
Chronic Kidney Disease Is Associated With White Matter Hyperintensity Volume: The Northern Manhattan Study (NOMAS)

Background and Purpose— White matter hyperintensities have been associated with increased risk of stroke, cognitive decline, and dementia. Chronic kidney disease is a risk factor for vascular disease and has been associated with inflammation and endothelial dysfunction, which have been implicated in the pathogenesis of white matter hyperintensities. Few studies have explored the relationship between chronic kidney disease and white matter hyperintensities. Methods— The Northern Manhattan Study is a prospective, community-based cohort of which a subset of stroke-free participants underwent MRIs. MRIs were analyzed quantitatively for white matter hyperintensities volume, which was log-transformed to yield a normal distribution (log-white matter hyperintensity volume). Kidney function was modeled using serum creatinine, the Cockcroft-Gault formula for creatinine clearance, and the Modification of Diet in Renal Disease formula for estimated glomerular filtration rate. Creatinine clearance and estimated glomerular filtration rate were trichotomized to 15 to 60 mL/min, 60 to 90 mL/min, and >90 mL/min (reference). Linear regression was used to measure the association between kidney function and log-white matter hyperintensity volume adjusting for age, gender, race–ethnicity, education, cardiac disease, diabetes, homocysteine, and hypertension. Results— Baseline data were available on 615 subjects (mean age 70 years, 60% women, 18% whites, 21% blacks, 62% Hispanics). In multivariate analysis, creatinine clearance 15 to 60 mL/min was associated with increased log-white matter hyperintensity volume (&bgr; 0.322; 95% CI, 0.095 to 0.550) as was estimated glomerular filtration rate 15 to 60 mL/min (&bgr; 0.322; 95% CI, 0.080 to 0.564). Serum creatinine, per 1-mg/dL increase, was also positively associated with log-white matter hyperintensity volume (&bgr; 1.479; 95% CI, 1.067 to 2.050). Conclusions— The association between moderate–severe chronic kidney disease and white matter hyperintensity volume highlights the growing importance of kidney disease as a possible determinant of cerebrovascular disease and/or as a marker of microangiopathy.
Complex fans: a representation for vectors in polar form with interval attributes

If we allow the magnitude and angle of a complex number (expressed in polar form) to range over an interval, it describes a semicircular region, similar to a fan; these regions are what we call complex fans. Complex numbers are a special case of complex fans, where the magnitude and angle are point intervals. Operations (especially addition) with complex numbers in polar form are complicated. What most applications do is to convert them to rectangular form, perform operations, and return the result to polar form. However, if the complex number is a Complex Fan, that transformation increases ambiguity in the result. That is, the resulting Fan is not the smallest Fan that contains all possible results. The need for minimal results took us to develop algorithms to perform the basic arithmetic operations with complex fans, ensuring the result will always be the smallest possible complex fan. We have developed the arithmetic operations of addition, negation, subtraction, product, and division of complex fans. The algorithms presented in this article are written in pseudocode, and the programs in Common Lisp, making use of CLOS (Common Lisp Object System). Translation to any other high-level programming language should be straightforward.
Multilaboratory evaluation of 15 bioassays for (eco)toxicity screening and hazard ranking of engineered nanomaterials: FP7 project NANOVALID

Abstract Within EU FP7 project NANOVALID, the (eco)toxicity of 7 well-characterized engineered nanomaterials (NMs) was evaluated by 15 bioassays in 4 laboratories. The highest tested nominal concentration of NMs was 100 mg/l. The panel of the bioassays yielded the following toxicity order: Ag > ZnO > CuO > TiO2 > MWCNTs > SiO2 > Au. Ag, ZnO and CuO proved very toxic in the majority of assays, assumingly due to dissolution. The latter was supported by the parallel analysis of the toxicity of respective soluble metal salts. The most sensitive tests/species were Daphnia magna (towards Ag NMs, 24-h EC50 = 0.003 mg Ag/l), algae Raphidocelis subcapitata (ZnO and CuO, 72-h EC50 = 0.14 mg Zn/l and 0.7 mg Cu/l, respectively) and murine fibroblasts BALB/3T3 (CuO, 48-h EC50 = 0.7 mg Cu/l). MWCNTs showed toxicity only towards rat alveolar macrophages (EC50 = 15.3 mg/l) assumingly due to high aspect ratio and TiO2 towards R. subcapitata (EC50 = 6.8 mg Ti/l) due to agglomeration of TiO2 and entrapment of algal cells. Finally, we constructed a decision tree to select the bioassays for hazard ranking of NMs. For NM testing, we recommend a multitrophic suite of 4 in vitro (eco)toxicity assays: 48-h D. magna immobilization (OECD202), 72-h R. subcapitata growth inhibition (OECD201), 30-min Vibrio fischeri bioluminescence inhibition (ISO2010) and 48-h murine fibroblast BALB/3T3 neutral red uptake in vitro (OECD129) representing crustaceans, algae, bacteria and mammalian cells, respectively. Notably, our results showed that these assays, standardized for toxicity evaluation of “regular” chemicals, proved efficient also for shortlisting of hazardous NMs. Additional assays are recommended for immunotoxicity evaluation of high aspect ratio NMs (such as MWCNTs).
Situating learning in communities of practice

What would happen if a different eye, culturally and historically sensitized by an excursion through forms of apprenticeship i n different parts of the world, e-rrc turned on specific contemporary cultural and historical features of learning pr,:, . ;-<: . L ~ : . as these are situated i n communities of practice in tht United States? I < . l i h t ~ rh:jn turning to school-like activities for confirmation and guidance about tile llalur;. of learning, that gaze ~ ~ o u l d reverse the perspective from which ~:~:l-~r~l:rsl. ~gists look outward from their culture onto another. 11 would draw c 8 r 1 {r-h::r i s known about learning i n forms of apprenticeship in other cultures 1 8 . 1 ir3l::ilj? r learning in our own sociocultural, historically grounded world. Ldn:h ;I 7 lew in\lites a rethinking of the norion of learning, treating it as an c! ii.rF! rl~ property of whole persons' legitimate peripheral participation in com! ~ ~ ~ n i ~ i c s of practice. Such a view sees mind, culture, history, and the social r 4 , : : l d . :F interrelated processes that constitute each other, and intentionally
Urinary Microvesicle-Bound Uromodulin: A Potential Molecular Biomarker in Diabetic Kidney Disease

This study was designed to investigate the changes of urinary microvesicle-bound uromodulin and total urinary uromodulin levels in human urine and the correlations with the severity of diabetic kidney disease (DKD). 31 healthy subjects without diabetes and 100 patients with type 2 diabetes mellitus (T2DM) were included in this study. The patients with T2DM were divided into three groups based on the urinary albumin/creatinine ratio (UACR): normoalbuminuria group (DM, n = 46); microalbuminuria group (DN1, n = 32); and macroalbuminuria group (DN2, n = 22). We use a specific monoclonal antibody AD-1 to capture the urinary microvesicles. Urinary microvesicle-bound uromodulin and total urinary uromodulin levels were determined by enzyme-linked immunosorbent assay (ELISA). Our results showed that the levels of urinary microvesicle-bound uromodulin in DN1 and DN2 groups were significantly higher than those in control group and DM group (P < 0.01). Multiple stepwise linear regression analysis showed that UACR was independent determinant for urinary microvesicle-bound uromodulin (P < 0.05) but not for total urinary uromodulin. These findings suggest that the levels of urinary microvesicle-bound uromodulin are associated with the severity of DKD. The uromodulin in urinary microvesicles may be a specific marker of DKD and potentially may be used to predict the onset and/or monitor the progression of DKD.
The Neural Correlates of Competition during Memory Retrieval Are Modulated by Attention to the Cues

Keywords: Fan effect Left ventrolateral prefrontal cortex (VLPFC) Parahippocampal place area (PPA) ACT-R Reactivation a b s t r a c t As people learn more facts about a concept, those facts become more difficult to remember. This is called the fan effect, where fan refers to the number of facts known about a concept. Increasing fan has been shown to decrease accuracy and increase response time and left ventrolateral prefrontal cortex (VLPFC) activity during retrieval. In this study, participants learned 36 arbitrary person–location pairings and made recognition decisions while we recorded brain activity using fMRI. We separately manipulated the fan of each person and location, as well as the training procedure with which each pair was studied. In the person focus condition, participants studied pairs with a picture of the person's face and used the person as a retrieval cue during training. In the location focus condition, participants studied pairs with a picture of the location and used the location as a retrieval cue during training. We found that the fan of the focused cue had a greater effect on response time, accuracy, and left VLPFC activity during retrieval than the fan of the unfocused cue. We also found that the parahippocampal place area (PPA) was more active during the recognition of pairs studied in the location focus condition, but not when the fan of the location was high. Overall, we found opposite effects of fan on VLPFC and PPA that were modulated by cue focus.
Are Accruals Really Mispriced ? Evidence from Tests of an Intertemporal Capital Asset Pricing Model

This paper examines the anomaly, first reported by Sloan (1996), that the market misprices stocks of firms with extreme (high or low) accruals. The paper proposes a four-factor ICAPM, based on Campbell and Vuolteenaho (2004) and Fama and French (1993), and tests the model using a two-pass cross-sectional regression. Two principal findings are reported. First, the model successfully prices the cross-section of accrual portfolios with an error that is statistically indistinguishable from zero at conventional sizes. In addition, abnormal returns to a variety of hedge portfolios are statistically or economically insignificant. These results do not hold for the CAPM and the FamaFrench three-factor model. Secondly, tests based on Chan and Chen (1991) reveal that the return behavior of the low accrual portfolio mimics the return behavior of a portfolio of firms with high bankruptcy risk. In sum, the evidence suggests that (i) cross-sectional variation in average returns to high and low accrual firms is due to differences in risk rather than mispricing, and (ii) these differences in risk are not due to accruals per se, but rather, to well-known economic and financial distress characteristics that are correlated with accruals. * Joseph L. Rotman School of Management, 105 St. George St., Toronto, Ontario, M5S 3E6, Canada. Email: mozaffar.khan00@rotman.utoronto. ca Tel: 416-946-8064. This paper is based on my dissertation, undertaken at the University of Toronto. I am indebted to the members of my committee: Jeff Callen (Chair), for being an enduring source of inspiration and support, and without whom this paper would not have been possible; Raymond Kan, for always graciously sharing his time and expertise; and Gordon Richardson and Dan Segal, for their guidance. I am grateful to Professor Ross Watts for valuable discussions and support. Helpful comments were received from Gauri Bhat, Gus DeFranco, Andras Fulop, Ole-Kristian Hope, Hai Lu, Jan Mahrt-Smith and seminar participants at the University of Toronto. I appreciate valuable comments from Professor Ray Ball on an earlier draft of the paper. This paper is to be presented at the 2005 AAA FARS midyear conference. I thank an anonymous FARS reviewer for useful comments.
Goal Setting in Sport and Exercise: A Research Synthesis to Resolve the Controversy

Although the motivational technique of goal setting has consistently and reliably improved performance in industrial psychology research, this beneficial effect has not been clearly demonstrated in the sport domain. The many proposed explanations for this discrepancy have resulted in a controversy in the literature. However, scientists have overlooked the importance of statistical power. A meta-analytic review of the literature investigating the effects of goal setting on performance in sport and exercise could help to clarify the state of knowledge. The meta-analytic procedures described by Hedges and Olkin (1985) were used to statistically combine 36 studies identified as meeting inclusion criteria. Results indicate that, overall, setting goals improves sport by 0.34 of a standard deviation. Moderate, absolute, and combined short- and long-term goals were associated with the greatest effects. Additional moderator variables were identified, and the extent to which they alter the goal setting–performance .
The origin of the initial mass function and its dependence on the mean Jeans mass in molecular clouds

We investigate the dependence of stellar properties on the mean thermal Jeans mass in molecular clouds. We compare the results from the two largest hydrodynamical simulations of star formation to resolve the fragmentation process down to the opacity limit, the first of which was reported by Bate, Bonnell & Bromm. The initial conditions of the two calculations are identical except for the radii of the clouds, which are chosen so that the mean densities and mean thermal Jeans masses of the clouds differ by factors of 9 and 3, respectively. We find that the denser cloud, with the lower mean thermal Jeans mass, produces a higher proportion of brown dwarfs and has a lower characteristic (median) mass of the stars and brown dwarfs. This dependence of the initial mass function (IMF) on the density of the cloud may explain the observation that the Taurus star-forming region appears to be deficient in brown dwarfs when compared with the Orion Trapezium cluster. The new calculation also produces wide binaries (separations >20 au), one of which is a wide binary brown dwarf system. Based on the hydrodynamical calculations, we develop a simple accretion/ejection model for the origin of the IMF. In the model, all stars and brown dwarfs begin with the same mass (set by the opacity limit for fragmentation) and grow in mass until their accretion is terminated stochastically by their ejection from the cloud through dynamically interactions. The model predicts that the main variation of the IMF in different star-forming environments should be in the location of the peak (due to variations in the mean thermal Jeans mass of the cloud) and in the substellar regime. However, the slope of the IMF at high masses may depend on the dispersion in the accretion rates of protostars. Ke yw ords: accretion, accretion discs ‐ hydrodynamics ‐ binaries: general ‐ stars: formation ‐ stars: low-mass, brown dwarfs ‐ stars: luminosity function, mass function.
Hyperbolic manifolds of dimension $n$ with automorphism group of dimension $n^2-1$

We consider complex Kobayashi-hyperbolic manifolds of dimension $n\ge 2$ for which the dimension of the group of holomorphic automorphisms is equal to $n^2-1$. We give a complete classification of such manifolds for $n\ge 3$ and discuss several examples for $n=2$.