Miracle-dz/UniFAR-FTUs huggingface dataset:
THE IMPACT OF INDIVIDUAL CHARACTERISTICS ON INTENTIONS TO PURSUE SOCIAL ENTREPRENEURSHIP

Social entrepreneurship is a growing phenomenon, both in practice and in the scientific community. The main goal of this research is to examine specific personal characteristics that might support one’s decision to pursue social entrepreneurship as a career choice. The research sample consisted of 114 students of two graduate entrepreneurship programs: Economics of Entrepreneurship at the Faculty of Organization and Informatics in Varaždin, University of Zagreb ; and Entrepreneurship at the Faculty of Economics, J. J. Strossmayer University of Osijek. Based on the scientific literature, we identified several potentially important personal characteristics: creativity, proactivity, compassionate love for humanity, hardship in life and moral judgement competence. These characteristics were adequately measured and compared between three groups of students: those that want to become commercial entrepreneurs, those that want to become social entrepreneurs, and those who have no entrepreneurial intentions. The methods we used were one-way ANOVA and factor analysis. Our results showed that the factor that differed the most between the observed groups was compassionate love for humanity. This factor might be the main driving force behind social entrepreneurial activities.
GeneRAGE: a robust algorithm for sequence clustering and domain detection

MOTIVATION Efficient, accurate and automatic clustering of large protein sequence datasets, such as complete proteomes, into families, according to sequence similarity. Detection and correction of false positive and negative relationships with subsequent detection and resolution of multi-domain proteins. RESULTS A new algorithm for the automatic clustering of protein sequence datasets has been developed. This algorithm represents all similarity relationships within the dataset in a binary matrix. Removal of false positives is achieved through subsequent symmetrification of the matrix using a Smith-Waterman dynamic programming alignment algorithm. Detection of multi-domain protein families and further false positive relationships within the symmetrical matrix is achieved through iterative processing of matrix elements with successive rounds of Smith-Waterman dynamic programming alignments. Recursive single-linkage clustering of the corrected matrix allows efficient and accurate family representation for each protein in the dataset. Initial clusters containing multi-domain families, are split into their constituent clusters using the information obtained by the multi-domain detection step. This algorithm can hence quickly and accurately cluster large protein datasets into families. Problems due to the presence of multi-domain proteins are minimized, allowing more precise clustering information to be obtained automatically. AVAILABILITY GeneRAGE (version 1.0) executable binaries for most platforms may be obtained from the authors on request. The system is available to academic users free of charge under license.
Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging.

PURPOSE To quantify changes in choriocapillary density and in thickness of Bruch's membrane, the choriocapillaris, and the choroid in 95 unpaired, histologically normal human maculae aged 6 to 100 years and in 25 maculae with advanced age-related macular degeneration. METHODS Light microscopic, computer-aided, morphometric quantitative analysis. RESULTS In ten decades, Bruch's membrane thickness increased by 135%, from 2.0 to 4.7 microns; the choriocapillary density decreased by 45%; the diameter of the choriocapillaris decreased by 34%, from 9.8 to 6.5 microns; and the choroidal thickness decreased by 57%, from 193.5 to 84 microns in normal maculae. In maculae with basal laminar deposit, geographic atrophy, or disciform scarring, the density of the choriocapillaris was 63%, 54%, and 43% of normal and the choriocapillary diameter was 81%, 73%, and 75% of normal, respectively. Choroidal thickness remained unchanged. CONCLUSIONS Thickness of Bruch's membrane was only related to age (rs = 0.63) and not to age-related atrophy of the choriocapillaris. Age was also the strongest factor related to choriocapillary density (rs = -0.58). In advanced stages of age-related macular degeneration, the decrease in choriocapillary density and diameter was significantly larger than in normal maculae, but the thickness of the choroid and Bruch's membrane was the same. The latter was significantly thinner (81% of normal) in disciform scarring.
Computing Strongly Connected Components in Parallel on CUDA

The problem of decomposing a directed graph into its strongly connected components is a fundamental graph problem inherently present in many scientific and commercial applications. In this paper we show how some of the existing parallel algorithms can be reformulated in order to be accelerated by NVIDIA CUDA technology. In particular, we design a new CUDA-aware procedure for pivot selection and we adapt selected parallel algorithms for CUDA accelerated computation. We also experimentally demonstrate that with a single GTX 480 GPU card we can easily outperform the optimal serial CPU implementation by an order of magnitude in most cases, 40 times on some sufficiently big instances. This is an interesting result as unlike the serial CPU case, the asymptotic complexity of the parallel algorithms is not optimal.
Images as embedding maps and minimal surfaces: movies, color, and volumetric medical images

A general geometrical framework for image processing is presented. We consider intensity images as surfaces in the (x, I) space. The image is thereby a two dimensional surface in three dimensional space for gray level images. The new formulation unifies many classical schemes, algorithms, and measures via choices of parameters in "master" geometrical measure. More important, it is a simple and efficient tool for the design of natural schemes for image enhancement, segmentation, and scale space. Here we give the basic motivation and apply the scheme to enhance images. We present the concept of an image as a surface in dimensions higher than the three dimensional intuitive space. This will help us handle movies, color, and volumetric medical images.
A clinical evaluation of platelet function, haemolysis and oxygen transfer during cardiopulmonary bypass comparing the Quantum HF-6700 to the HF-5700 hollow fibre membrane oxygenator

The continued improvement of oxygenators is an important aspect of patient safety during cardiopulmonary bypass (CPB). The purpose of this study was to compare the Bard William Harvey HF-5700 oxygenator to the upgraded Bard Quantum HF-6700, which has recently been introduced into clinical practice. No clinical evaluation of this device has been published to date. The two oxygenators differ principally in that the Quantum has a smaller priming volume, achieved at the expense of a smaller membrane surface area which could result in sub-optimal gas exchange characteristics, increased haemolysis and increased platelet dysfunction during CPB. Twenty adult patients undergoing elective, first time coronary artery bypass grafting (CABG) were randomly assigned either to the HF-5700 (n=10) or to the HF-6700 (n=10) group. One patient underwent mitral valve repair in addition to CABG and was excluded from further study. There were no statistically significant differences in either preoperative or operative parameters between the two groups. Samples were obtained at the start of CPB, at 30 min, 60 min, at the end of CPB and at 1 h following termination of CPB. No significant differences between the two groups were found in oxygen transfer, haemolysis (plasma haptoglobin levels) or platelet function (a novel platelet activating factor (PAF)-induced platelet activation test) at any of the time points during CPB. It was concluded that the Quantum HF-6700 matches the HF-5700 for the parameters studied, whilst having the advantage of requiring a smaller priming volume.
REAL-TIME NOVEL RENDERING ARCHITECTURE FOR 3 D DISPLAY

This paper proposed the novel rendering architecture based on GPU massive multithreading for generating multi-view content to 3D display. With the input of 2D plus depth images, this system can support stereoscopic display as well as auto-stereoscopic one. In order to achieve real-time and high quality depth image based rendering (DIBR), anti-aliasing pixel rendering, unoccupied pixel inpainting and multi-view interlacing are proposed and optimized based on parallel architecture. Meanwhile, the GPU-based resizing is also developed by using GPU CUDA interpolation function. The antialiasing pixel rendering algorithm, considering occluding effect simultaneously, is to solve the depth aliasing and disparity quantization problem by using floating-point based mapping to check occupying proportion. Verification on NVIDIA GeForce GTX280 GPU has demonstrated the real-time high quality performance for the proposed novel rendering architecture. Keywords-component: 3D display, anti-aliasing, depth image based rendering, GPU, CUDA
Dynamic optimistic interprocedural analysis: a framework and an application

In this paper, we address the problem of dynamic optimistic interprocedural analysis. Our goal is to build on past work on static interprocedural analysis and dynamic optimization by combining their advantages. We present a framework for performing dynamic optimistic interprocedural analysis. the framework is designed to be used in the context of dynamic class loading and dynamic compilation, and includes mechanisms for event notification (on class loading and method compilation) and dependence tracking (to enable invalidation of optimistic assumptions). We illustrate the functionality of the framework by using it to be used in the context of dynamic class loading and dynamic compilation, and includes mechanisms for event notification (on class loading and method compilaton) and dependence tracking (to enable invalidation of optimistic assumptions). We illustrate the functionality of the framework by using it to implement a dynamic optimistic interprocedural type (DOIT) analysis algorithm. The DOIT algorithm uses a new global data structure called the Value Graph. The framework and DOIT analysis of the IBM Jalapeño Java virtual machine. Our experimental results for the SPECjvm benchmarks and two larger programs show promising benefits due to dynamic optimistic analysis. Compared to pessimistic analysis, the reduction in number of methods and fields analyzed was in the 2.7x-4.6x and 1.6-2.4x ranges respectively. The average fraction of polymorphic virtual calls decreased from 39.5% to 24.4% due to optimistic analysis, with a best-case decrease from 47.0% to 8.1%. The average fraction of polymorphic interface calls decreased from 96.4% to 36.2% due to optimistic analysis, with a best-case decrease from 100.0% to 0.0%. These benefits were obtained with a low dynamic analysis overhead in the range of 570-930 bytecode bytes/millisecond (about 2.5x-5.4x faster than the Jalapeño baseline compiler)
Multiple pigmented clear cell acanthoma in an African patient

5 mg prednisolone and 150 mg azathioprine per day for several years. In 2011, at the age of 43, she suddenly developed multiple basal cell carcinomas in the face and trunk (Fig. 1a). We detected pits on the dorsal and palmar area of both hands, too (Fig. 1b). When asked about her medical history, the patient reported a surgical treatment of jaw cysts. Family investigations showed pits and lesions suspicious of basal cell carcinoma in one of her four children. A human genetic investigation showed that our patient as well as her son were heterozygous for a mutation in exon 19 of the PTCH1 gene (c.3296A>G, p.H1099R). From April 2011 to September 2013, 39 of the patient’s basal cell carcinomas were treated via surgery. At the end of 2013 the patient did not want anymore surgery because of the major psychological burden, so treatment with vismodegib was initiated. Under this regimen basal cell carcinomas as well as pits on the dorsaland palmar-hand side diminished. The concomitant PV has been treated with 5 mg prednisolone and 100 mg azathioprine parallel to surgical treatment. The autoimmunobullous antibodies as well as the indirect immunofluorescence were negative in her NBCCS-affected son. Concerning the genetic PV background a HLA typing was additionally done in our patient and her son (Table 1). The primary mutations in NBCCS are found in the PTCH1 gene, which is involved in the Hedgehog pathway and has a tumour suppression function. A range of new mutations in this gene has been described recently. In our patient and her affected son we found a heterozygous missense mutation in exon 19 of the PTCH1 gene (c.3296A>G, p.H1099R). According to the HGMD professional database (version 2014.1), this mutation has not been described until now. The affected amino acid histidine at position 1099 is highly conserved from Homo sapiens to C. elegans and is part of the transmembrane domain 10 of PTCH1. PolyPhen2 (http://genetics.bwh.harvard.edu/ggi/pph2/) predicted the change as ‘probably damaging’ and Mutation taster (http://www.mutationtaster.org/) as ‘disease causing’. The genetic background for concomitant PV is a different one, which focuses on an association with HLA class II genes. More than 95 % of these patients carry one of the DRB1*0402, DQB1*0503 allele respectively. An additionally significant increase in subtype DQB1*0503 (in linkage with DRB1*14) as well as DQB1*0302 (in linkage with DRB1*04) could be shown in molecular analysis. In our patient HLA-DRB1*14 and HLA-DQB1*05 were detected in HLA typing as described in the literature, too. In contrast to the mother, her son (without PV) neither experienced this linkage nor autoimmune antibodies against desmoglein 3 (Table 1). We present a case with concomitant NBCCS and PV in which a novel mutation in the PTCH1 gene could be detected. How far these conditions are associated with each other or whether there are two different pathological manifestations remains unknown.
Effect of Epinephrine on Pressure, Flow, and Volume Relationships in the Systemic Circulation of Dogs

The effect of epinephrine on peripheral circulation was studied in ten anesthetized open-chest dogs. Blood flow and right atrial pressure were independently controlled by a right heart bypass; changes in blood volume could be precisely determined from the changes occurring in the bypass reservoir. At constant blood flow and right atrial pressure, a constant infusion of epinephrine (5.8 μg/kg min−1) decreased blood volume by an average of 208 ml. During epinephrine infusion, the ratio of changes in blood volume to changes in blood flow measured at constant right atrial pressure, (ΔV/ΔQ˙)Pra, decreased from 0.226 minutes to 0.153 minutes and the ratio of changes in blood volume to changes in right atrial pressure at constant blood flow, the vascular compliance, decreased from 27.1 ml/cm H2O to 20.7 ml/cm H2O. Transient changes in blood volume following a step decrease in right atrial pressure at constant blood flow showed that blood was draining from two vascular compartments with different time constants: 0.059 minutes and 0.388 minutes before epinephrine infusion and 0.058 minutes and 0.486 minutes during epinephrine infusion. We analyzed the data using a mathematical model of the peripheral circulation consisting of two compartments with different time constants. The analysis showed that the primary effect of epinephrine on the systemic circulation was to redistribute blood flow away from the compartment with the longest time constant. The reduction in (ΔV/ΔQ˙)pra and the decrease in blood volume at constant flow and right atrial pressure were essentially determined by the change in flow distribution brought about by a change in arteriolar tone and not by a change in venous tone.
Interactive learning systems for higher education: Learning styles and students' attitude

This dissertation reports research concerning the adaptation of learning systems to students' different learning styles (LSs), particularly in relation to the analysis and planning of Interactive Learning Systems (ILSs). Given the primacy of Interactive Learning and its pedagogical implication on educational designs, the motivation for this research is better understanding of students' different learning preferences and perceptions of Computer Mediated Learning Interactions (CMLIs), as this may present some insights into what and how interactivity can be incorporated more purposefully and efficiently into learning systems designs. This research undertakes a review of the literature relating to LSs' theories, which have been used to explore how individual learners approach learning, as well as different Learning Interactions in relation to Interactive Learning Systems (ILSs). The work undertaken in this research makes its contribution to the field in that it represents one of the first explicit investigations of the relationship between students' LSs (ActiveReflective/Visual Verbal dimensions) and their attitude towards different CMLIs that constitute essential part of ILSs, in terms of use, perceptions and learning preferences, from the users' (learners) perspective rather than the teachers and/or designers of these systems. The research provides evidence to support the differing views of learners of different LSs as well as evidence of common attitudes towards certain CMLIs. However, it warns against and highlights some of the limitations of using the LSs in isolation and the importance of considering other factors and aspects of students' individual differences. A model is proposed to guide the planning and design of ILSs, and to raise the designers' and teachers' awareness of learners' differences and call upon them to take necessary steps to consider actual learners' LSs in the learning design. Implications of the findings in terms of interactivity design considerations are discussed; research limitations and recommendations for future work are made. Interactive Learning Systems for HE K. A. Sabry
Impedance Properties of Metal Electrodes for Chronic Recording from Mammalian Nerves

Over the last few years methods have been developed for recording chronically from mammalian nerves with implanted electrodes contained in silastic cuffs. The impedance of the electrodes and the changes that take place over time were studied. Platinum-iridium electrodes remain stable over long periods of time, whereas the impedance of silver wire electrodes increases and eventually the silver fractures. The impedance at low frequencies (e.g., 10 Hz) provides a measure of the capacitance of the metal electrodes, whereas the impedance at higher frequencies (1 kHz) mainly measures the resistance of the tissue filling the cuff. Increases in resistance due to growth of connective tissue around intact nerves have been studied as well as changes in resistance after cutting a nerve. Impedance measurements provide a useful way to follow the properties of electrodes and nerves in basic neuroscientific research and in future clinical applications of these chronic recording methods.
Discrete event simulation as a tool in optimization of a professional complex adaptive system

Similar urgent needs for improvement of health care systems exist in the developed and developing world. The culture and the organization of an emergency department in developing countries can best be described as a professional complex adaptive system, where each agent (employee) are ignorant of the behavior of the system as a whole; no one understands the entire system. Each agent's action is based on the state of the system at the moment (i.e. lack of medicine, unavailable laboratory investigation, lack of beds and lack of staff in certain functions). An important question is how one can improve the emergency service within the given constraints. The use of simulation signals is one new approach in studying issues amenable to improvement. Discrete event simulation was used to simulate part of the patient flow in an emergency department. A simple model was built using a prototyping approach. The simulation showed that a minor rotation among the nurses could reduce the mean number of visitors that had to be refereed to alternative flows within the hospital from 87 to 37 on a daily basis with a mean utilization of the staff between 95.8% (the nurses) and 87.4% (the doctors). We conclude that even faced with resource constraints and lack of accessible data discrete event simulation is a tool that can be used successfully to study the consequences of changes in very complex and self organizing professional complex adaptive systems.
Nuevo mapa de los mitos sobre la violencia de género en el siglo XXI

Este trabajo tiene como fi nalidad presentar una aproximacion a la vigencia actual de los mitos sobre violencia de genero, que son defi nidos como creencias estereotipicas sobre dicha violencia, que son generalmente falsas, pero que son sostenidas amplia y persistentemente. Estos mitos han sido estudiados clasifi candolos en diferentes categorias (mitos sobre la marginalidad, mitos sobre los maltratadores, mitos sobre las mujeres maltratadas). A ellos, y en el marco de las nuevas formas de sexismo, se sumarian lo que se ha dado en llamar “neomitos”, entre los que estarian aquellos que minimizan la importancia del problema o, incluso dando un paso mas alla, aquellos que niegan su existencia. En este trabajo se analiza el alcance y extension de estos nuevos mitos. New map of the myths about gender violence in XXI century. This paper presents an approach to the contemporary relevance of the myths about domestic violence, which are defi ned as stereotypical beliefs about such violence, which are generally false but persistent. These myths have been studied and classifi ed into diverse categories (marginality myths, myths about offenders, battered women myths). To them, and within the context of new forms of sexism, would be added what has been called “new myths”, including those that minimize the importance of the problem or, even going one step further, those that deny its existence. This paper discusses the scope and extent of these new myths.
Csde1 cooperates with Strap to control translation of erythroid transcripts

Erythropoiesis is regulated at many levels, including control of mRNA translation. Changing environmental conditions, such as hypoxia, or the availability of nutrients and growth factors, require a rapid response enacted by the enhanced or repressed translation of existing transcripts. Csde1 is an RNA-binding protein required for erythropoiesis and strongly upregulated in erythroblasts relative to other hematopoietic progenitors. The aim of this study is to identify the Csde1-containing protein complexes, and investigate their role in regulating the translation of Csde1-bound transcripts. We show that Strap, also called Unrip, was the protein most strongly associated with Csde1 in erythroblasts. Strap is a WD40 protein involved in signaling and RNA splicing, but its role is unknown when associated with Csde1. Reduced expression of Strap did not alter the pool of transcripts bound by Csde1. Instead, it reduced the mRNA and/or protein expression of several Csde1-bound transcript, that encode for proteins essential for translational regulation during hypoxia, such as Hmbs, eIF4g3 and Pabpc4. Also affected by Strap knockdown were Vim, a Gata-1 target crucial for erythrocyte enucleation, and Elavl1, which stabilizes Gata-1 mRNA. Thus, we found that the Csde1/Strap complex is at the crossroad of multiple pathways governing translation in erythroblasts.