Miracle-dz/UniFAR-FTUs huggingface dataset:
A Clinical Evaluation Denture Adhesives Used by Patients With Xerostomia

AbstractThe purpose of study was to analyze the participants’ opinions concerning the effectiveness of 6 denture adhesives (DA). The study group included 60 participants. Criteria for selecting the patients were as follows: reduced retention and stabilization of maxillary complete dentures and xerostomia. These features were evaluated on basis of clinical examination and standard sialometry tests (u-SFR). Retention of maxillary dentures was scored by modified Kapur index before application of DA. All participants were divided randomly into 6 groups regarding the use of the 6 DA during a 6-month period. After this time, participants completed an HRQL questionnaire.DA noticeably improved retention and stabilization of maxillary complete dentures. DA in the glue form had the best retention effectiveness in participants with xerostomia. These materials are difficult to clean from the denture base. The data are presented in tables and figures.The results of the study collected positive influence of adhesives on retention of dentures in xerostomia patients. The cleaning dentures and denture bearing tissues was difficult.DA help in the use of prostheses, but it is also necessary for the treatment of the causes and symptoms of xerostomia.
Impact of Singular Excessive Computer Game and Television Exposure on Sleep Patterns and Memory Performance of School-aged Children

OBJECTIVE. Television and computer game consumption are a powerful influence in the lives of most children. Previous evidence has supported the notion that media exposure could impair a variety of behavioral characteristics. Excessive television viewing and computer game playing have been associated with many psychiatric symptoms, especially emotional and behavioral symptoms, somatic complaints, attention problems such as hyperactivity, and family interaction problems. Nevertheless, there is insufficient knowledge about the relationship between singular excessive media consumption on sleep patterns and linked implications on children. The aim of this study was to investigate the effects of singular excessive television and computer game consumption on sleep patterns and memory performance of children. METHODS. Eleven school-aged children were recruited for this polysomnographic study. Children were exposed to voluntary excessive television and computer game consumption. In the subsequent night, polysomnographic measurements were conducted to measure sleep-architecture and sleep-continuity parameters. In addition, a visual and verbal memory test was conducted before media stimulation and after the subsequent sleeping period to determine visuospatial and verbal memory performance. RESULTS. Only computer game playing resulted in significant reduced amounts of slow-wave sleep as well as significant declines in verbal memory performance. Prolonged sleep-onset latency and more stage 2 sleep were also detected after previous computer game consumption. No effects on rapid eye movement sleep were observed. Television viewing reduced sleep efficiency significantly but did not affect sleep patterns. CONCLUSIONS. The results suggest that television and computer game exposure affect children's sleep and deteriorate verbal cognitive performance, which supports the hypothesis of the negative influence of media consumption on children's sleep, learning, and memory.
International Journal of Medical Informatics

Objective The Health Risk Reminders and Surveillance (HRRS) system was designed to deliver critical abnormal test results of severely ill patients from Laboratory, Radiology, and Pathology departments to physicians within 5 min using cell phone text messages. This paper explores the success of the HRRS system. Method This study employed an augmented version of the DeLone and McLean IS success model. Seven variables (system quality, information quality, system use, user satisfaction, mobile healthcare anxiety, impact on the individual and impact on the organization) were used to evaluate the success of the HRRS system. The interrelationships between the seven variables were hypothesized and the hypotheses were empirically tested. Results The results indicate that the information quality of the HRRS system is positively associated with both system use and user satisfaction. In addition, system use is positively associated with user satisfaction, which is also positively associated with mobile healthcare anxiety. Moreover, results indicate that impact on the individual is positively associated with both user satisfaction and mobile healthcare anxiety. Finally, the impact of the organization is positively associated with impact on the individual. Conclusion The results of the study provide an expanded understanding of the factors that contribute to mobile patient safety information system (IS) success. Implications of the relationship between system use and physician mobile healthcare anxiety are discussed.
The kinase activity of human Rio1 is required for final steps of cytoplasmic maturation of 40S subunits

hRio1 is an atypical protein kinase of the conserved RIO family. Depletion of hRio1 affects the last step of 18S rRNA maturation and causes defects in recycling of trans-acting factors from pre-40S subunits in the cytoplasm. The kinase activity of hRio1 is essential for recycling of the endonuclease hNob1 and its binding partner hDim2 from pre-40S.
Simplifying Distributed Application Upgrades with Simultaneous Execution

Abstract : Developers and operators of distributed systems today face a difficult choice. To provide for the evolution of their systems, they can either require that the software running on all nodes be interoperable, or they can shut down the entire system when an upgrade is required. Requiring interoperability complicates the life of system developers, while shutting down the system annoys users. We propose simultaneous execution, a middle ground between these approaches: an upgrade methodology that reduces the extent of support required for interoperability, while also providing system availability during upgrades. We demonstrate the benefits of our approach by applying it to two widely different distributed systems: the Cooperative File System, and IRISLOG. Our proposal enables easy upgrade of these systems while maintaining system availability, and requiring only minimal support for interoperability.
Measurement Theory and Psychological Scaling

Daniel P. Hinton and Tracey Platt Introduction Quantitative research in every branch of psychology involves the measurement of psychological constructs, and consumer psychology is no exception. The use of tools to measure psychological constructs is known as psychometrics. This chapter will outline the use of psychometric measures within consumer psychology and related fields – both in academic and practice settings – and discuss the theory underlying psychological measurement, before exploring the process by which these measures are developed by psychologists.
Random Projections as Regularizers: Learning a Linear Discriminant Ensemble from Fewer Observations than Dimensions

We examine the performance of an ensemble of randomly-projected Fisher Linear Discriminant classifiers, focusing on the case when there are fewer training observations than data dimensions. Our ensemble is learned from a sequence of randomly-projected representations of the original high dimensional data and therefore for this approach data can be collected, stored and processed in such a compressed form. The specific form and simplicity of this ensemble permits a direct and much more detailed analysis than existing generic tools in previous works. In particular, we are able to derive the exact form of the generalization error of our ensemble, conditional on the training set, and based on this we give theoretical guarantees which directly link the performance of the ensemble to that of the corresponding linear discriminant learned in the full data space. To the best of our knowledge these are the first theoretical results to prove such an explicit link for any classifier and classifier ensemble pair. Furthermore we show that the randomly-projected ensemble is equivalent to implementing a sophisticated regularization scheme to the linear discriminant learned in the original data space and this prevents overfitting in conditions of small sample size where pseudo-inverse FLD learned in the data space is provably poor. We confirm theoretical findings with experiments, and demonstrate the utility of our approach on several datasets from the bioinformatics domain where fewer observations than dimensions are the norm.
Functional contribution of Pds 5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts

Sister chromatid cohesion is a fundamental aspect of chromosome behavior that ensures the accurate inheritance of the genetic information in mitosis and meiosis (reviewed by The central player of this process is cohesin, a conserved protein complex composed of a heterodimeric pair of structural maintenance of chromosomes (SMC) subunits, Smc1 and Smc3, and two additional non-SMC subunits, Scc3/SA and Scc1/Rad21. A native cohesin complex purified from human cells adopts a ring-shaped structure as revealed by electron microscopy (Anderson et al., 2002) consistent with the arrangement of cohesin subunits inferred from biochemical experiments in yeast (Haering et al., 2002). On the basis of these data and additional genetic experiments, it has been proposed that sister chromatids could be topologically trapped within the cohesin ring after DNA replication and cleavage of the Scc1 subunit in anaphase would open the ring to release the chromatids for separation (Gruber et al., 2003). Unlike Saccharomyces cerevisiae, the bulk of cohesin dissociates from chromatin during prophase in vertebrate cells (Losada et al., 1998; Losada et al., 2000; Waizenegger et al., 2000). This dissociation occurs without Scc1 cleavage and involves the action of the polo and aurora B kinases, yet its exact mechanism is not fully understood (Losada et al., 2002;
Computational study of a chance constrained portfolio selection problem

We study approximations of chance constrained problems. In particular, we consider the Sample Average Approximation (SAA) approach and discuss convergence properties of the resulting problem. A method for constructing bounds for the optimal value of the considered problem is discussed and we suggest how one should tune the underlying parameters to obtain a good approximation of the true problem. We apply these methods to a linear portfolio selection problem with returns following a multivariate lognormal distribution. In addition to the SAA, we also analyze the Scenario Approximation approach, which can be regarded as a special case of the SAA method. Our computational results indicate the scenario approximation method gives gives a conservative approximation to the original problem. Interpreting the chance constraint as a Value-at-Risk constraint, we consider another approximation replacing it by the Conditional Value-at-Risk constraint. Finally, we discuss a method to approximate a sum of lognormals that allows us to find a closed expression for the chance constrained problem and compute an efficient frontier for the lognormal case.
Credit Cycles

We construct a model of a dynamic economy in which lenders cannot force borrowers to repay their debts unless the debts are secured. In such an economy, durable assets play a dual role: not only are they factors of production, but they also serve as collateral for loans. The dynamic interaction between credit limits and asset prices turns out to be a powerful transmission mechanism by which the effects of shocks persist, amplify, and spill over to other sectors. We show that small, temporary shocks to technology or income distribution can generate large, persistent fluctuations in output and asset prices.
A Single Group Study into the Effect of Intralesional Tetra-O-Methyl Nordihydroguaiaretic Acid (M4N) in Oral Squamous Cell Carcinoma

Background : Oral squamous cell carcinoma is the most common cancer among males and third commonest among females in India. Conventional treatment is by surgery or radiotherapy either alone or in combination. Survival still remains poor with nearly 50% recurring within 2-years of treatment. Patients and Methods : Between November 1999 and April 2000, 21 patients with oral squamous cell carcinoma were recruited. Of these, 3 patients did not complete the intended treatment and were excluded from analysis. After obtaining an informed consent, intralesional tetra-O-methyl nordihydroguaiaretic acid (M4N, currently under development as EM-1421) was injected in doses of 20 mg/day for 3 or 5 days. After completion of this treatment, patients underwent surgical resection of the tumor followed by adjuvant radiotherapy if indicated. Toxicity was monitored by WHO toxicity criteria. Response was recorded as change in surface area, tumor necrosis, pathological response, molecular response complication and recurrences. Overall, disease free and of the patients. Disease free and overall survival at 5 years was 10/18 (55.6) % and 14/18 (71.7%) respectively. Down-regulation of Cdc2 was observed in 9/18 (50%) and of survivin in 10/18 (55.6%) patients. Tumor stage at presentation (p=0.01) and down regulation of survivin (p=0.01) were found to significantly correlate with disease free survival. Conclusions : Intralesional tetra-O-methyl nordihydroguaiaretic acid (M4N) appears to be well tolerated using an intralesional dose of up to 100mg (20mg / day) with no evidence of acute or deferred toxicity. M4N has demonstrated significant inhibition of cellular production of Cdc2 and survivin, a potent pro-apoptotic response. This effect translated into tumor necrosis and shrinkage even with this short exposure in association with concomitant surgery and / or radiation.
REFERENCE MODEL AND LYAPUNOV ANALYSIS APPROACH : APPLICATION TO AN INDUCTION MOTOR

Abstract This paper deals with a robust H2/H∞ synthesis and an analysis technique applied to an induction motor. In order to robustify a linearizing decoupled feedback against parametric variations, H2/H∞ controllers with a reference model are added. The main interests are performances and real decoupling between the rotor flux and the speed in spite of parameter variations. A stability analysis method using parameter-dependent Lyapunov function is also proposed to verify the global stability. Real time implementations are carried out.
The Chromosomal Constitution of Embryos Arising from Monopronuclear Oocytes in Programmes of Assisted Reproduction

The assessment of oocytes showing only one pronucleus during assisted reproduction is associated with uncertainty. A compilation of data on the genetic constitution of different developmental stages shows that affected oocytes are able to develop into haploid, diploid, and mosaic embryos with more or less complex chromosomal compositions. In the majority of cases (~80%), haploidy appears to be caused by gynogenesis, whereas parthenogenesis or androgenesis is less common. Most of the diploid embryos result from a fertilization event involving asynchronous formation of the two pronuclei or pronuclear fusion at a very early stage. Uniparental diploidy may sometimes occur if one pronucleus fails to develop and the other pronucleus already contains a diploid genome or alternatively a haploid genome undergoes endoreduplication. In general, the chance of obtaining a biparental diploid embryo appears higher after conventional in vitro fertilization than after intracytoplasmic sperm injection. If a transfer of embryos obtained from monopronuclear oocytes is envisaged, it should be tried to culture them up to the blastocyst since most haploid embryos are not able to reach this stage. Comprehensive counselling of patients on potential risks is advisable before transfer and a preimplantation genetic diagnosis could be offered if available.
Etiology and Treatment of Neuropsychological and Cognitive Deficits in Relation to Antisocial Behavior

Impaired neuropsychological and cognitive functioning are well-understood to be risk factors for antisocial behavior. There are, however, gaps in our knowledge of the etiology and effective treatment of neuropsychological and cognitive deficits. My dissertation examines these questions in a series of three papers. The first paper proposes a serial mediation model wherein neighborhood disadvantage and subsequent impaired neuropsychological functioning represent a partial explanation of the race-antisocial behavior relationship. In a community sample of male and female young adolescents, the hypothesized sequential path accounted for 10.8% of the relationship between race and antisocial behavior. The second paper examines the relationship between sleep and antisocial behavior, which has primarily been examined via correlational or extreme sleep deprivation studies. Using National Incidence-Based Reporting System and city-reported data, this paper exploits the natural experiment of daylight saving time (DST) to examine the effects of a very mild change in sleep on assault rates. The Monday directly following the advent of DST was associated with 3% fewer assaults as compared to the Monday a week later, which we hypothesize may be the result of fatigue. In contrast, we saw 3% more assaults following the return to standard time. The final paper examines a sample of incarcerated male adolescents longitudinally to test whether incarceration results in impaired cognition, and if so, whether a Cognitive Behavioral Therapy/Mindfulness intervention can protect against such impairments. Performance on three measures derived from an emotional go/no-go task significantly worsened from baseline to follow-up, however, two marginally significant time x group interactions suggest mindfulness may be potentially effective in buffering the adverse effects of imprisonment. While many scholars have postulated about adverse psychological effects of incarceration, this is one of the first papers to empirically document such effects. In totality, the proposed dissertation is intended to improve our understanding of the association between cognition and antisocial behavior through examining external and environmental influences on the brain. From a theoretical perspective, findings highlight the need to explore environmental correlates of neuropsychological and cognitive deficits. From an applied and policy perspective, findings indicate potential avenues for individual-level treatment that may positively impact behavior. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group Criminology First Advisor Adrian Raine This dissertation is available at ScholarlyCommons: https://repository.upenn. edu/edissertations/2960
Automatic synthesis of systolic arrays from uniform recurrent equations

We describe a systematic method for the design of systolic arrays. This method may be used for algorithms that can be expressed as a set of uniform recurrent equations over a convex set D of Cartesian coordinates. Most of the algorithms already considered for systolic implementation may be represented in this way. The methods consists of two steps: finding a timing-function for the computations that is compatible with the dependences introduced by the equations, then mapping the domain D onto another finite set of coordinates, each representing a processor of the systolic array, in such a way that concurrent computations are mapped onto different processors. The scheduling and mapping functions meet conditions that allow the full automation of the method. The method is exemplified on the convolution product and the matrix product.
Properties of the Traffic Output by a Leaky-Bucket Policer with Long-Range Dependent Input Traffic

Long-range dependence (LRD) is a largely verified property of Internet traffic, which severely affects queuing performance in network buffers. A common approach for guaranteeing performance requirements is to control the statistical profile of the input traffic by regulators based on the leaky bucket scheme. In this paper, we investigate by simulation how the l/falpha power-law spectrum of LRD traffic is altered when traffic is regulated by a leaky bucket policer. Analysis of the traffic spectral characteristics is carried out mainly by means of the modified Allan variance, a time-domain quantity with demonstrated superior accuracy in fractional-noise parameter estimation, recently introduced also for traffic analysis. This approach allows to get a finer insight into power-law spectral characteristics of policed traffic. We also investigate some other properties of the leaky bucket fed with LRD traffic, such as its dropping probability and its effect on queuing delay in a following FIFO scheduler.
Activated B cells express receptors for, and proliferate in response to, pure interleukin 2

In this study we investigated whether interleukin 2 (IL-2) acts on B cell proliferation and whether activated B cells express IL-2 receptors. First, the functional activity of immunoaffinity-purified or recombinant human IL-2 was studied in a B blast assay using positively selected murine surface Ig-positive cells that had been activated by lipopolysaccharide (LPS) plus anti-Ig antibodies (anti-Ig). In this assay, T cells were not detected by fluorescence-activated cell sorter analysis. It was found that both IL-2 preparations led to optimal B cell proliferation compared with supernatants obtained from murine or human spleen cells or murine cloned T helper cells. Second, we observed that the IL-2 requirement in this assay was about the same as in a proliferation assay using lectin-activated polyclonal murine Lyt-2- positive T cells. Third, analysis of the binding of radiolabeled immunoaffinity-purified IL-2 to B cells indicated that LPS plus anti-Ig- activated B cells expressed a mean of 3,500 IL-2 receptors per cell with an apparent dissociation constant of 150 pM. However, neither nonactivated B cells nor B cells activated by LPS alone exhibited significant specific IL-2 binding. The functional and the receptor data are consistent with the conclusion that IL-2 is a growth factor not only for T cells but also for B cells.
Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes.

BACKGROUND The European Pain in Cancer survey sought to increase understanding of cancer-related pain and treatment across Europe. PATIENTS AND METHODS Patients with all stages of cancer participated in a two-phase telephone survey conducted in 11 European countries and Israel in 2006-2007. The survey screened for patients experiencing pain at least weekly, then randomly selected adult patients with pain of at least moderate intensity occurring several times per week for the last month completed a detailed attitudinal questionnaire. RESULTS Of 5084 adult patients contacted, 56% suffered moderate-to-severe pain at least monthly. Of 573 patients randomly selected for the second survey phase, 77% were receiving prescription-only analgesics, with 41% taking strong opioids either alone or with other drugs for cancer-related pain. Of those prescribed analgesics, 63% experienced breakthrough pain. In all, 69% reported pain-related difficulties with everyday activities; however, 50% believed that their quality of life was not considered a priority in their overall care by their health care professional. CONCLUSIONS Across Europe and Israel, treatment of cancer pain is suboptimal. Pain and pain relief should be considered integral to the diagnosis and treatment of cancer; management guidelines should be revised to improve pain control in patients with cancer.