Miracle-dz/UniFAR-FTUs huggingface dataset:
Ergodic Capacity of Spatial Multiplexing MIMO Systems with ZF Receivers for Log-Normal Shadowing and Rayleigh Fading Channels

This paper presents a derivation of an expression for the ergodic capacity of spatial multiplexing multiple-input-multiple-output (MIMO) systems with zero-forcing (ZF) receivers and independent substream detection. Assuming that the channel is unknown at the transmitter but known at the receiver, the ergodic capacity is formulated as a function of log-normal shadowing and Rayleigh fading. Gauss-Hermite quadrature integration is used to approximate the ergodic capacity expression in a concise form. The proposed analytical approach allows investigation of the effects of the shadowing standard deviation and the transmit correlation. Numerical and simulation results confirm that under various composite channel scenarios, the analytical results match well with the simulation results.
Online trajectory planning of robot arms for interception of fast maneuvering object under torque and velocity constraints

This paper presents a novel approach to an online trajectory planning of robot arms for the interception of a fast-maneuvering object under torque and velocity constraints. A body axis is newly introduced as a trajectory-planning coordinate in order to meet the position and the velocity matching conditions for a smooth grasp of the fast-maneuvering object. Using the position of the object and the end-effector in the inertia axis, the acceleration commands are generated in the X-, Y-, and Z-directions of the body axis and the acceleration commands are modified considering the torque and the velocity constraints. The trajectory planning in the X-direction becomes the speed planning to achieve the maximum speed, whereas the trajectory planning in the Y- and Z-directions becomes the direction planning where a missile-guidance algorithm is employed to intercept the maneuvering object. Finally, the acceleration commands in the body axis are transformed into the angle commands of the end-effector in the joint axis, which is used as the actual trajectory commands in robot arms.
On the onset of runaway stellar collisions in dense star clusters: I. Dynamics of the first collision

We study the circumstances under which first collisions occur in young and dense star clusters. The initial conditions for our direct N-body simulations are chosen such that the clusters experience core collapse within a few million years, before the most massive stars have left the main sequence. It turns out that the first collision is typically driven by the most massive stars in the cluster. Upon arrival in the cluster core, by dynamical friction, massive stars tend to form binaries. The enhanced cross-section of the binary compared to a single star causes other stars to engage the binary. A collision between one of the binary components and the incoming third star is then mediated by the encounters between the binary and other cluster members. Due to the geometry of the binary-single star engagement the relative velocity at the moment of impact is substantially different than in a two-body encounter. This may have profound consequences for the further evolution of the collision product.
Psychiatric symptoms in children with primary headache.

OBJECTIVE To examine the association of psychiatric symptoms with migraine and tension-type headache in children. METHOD A questionnaire completed by 1,135 Finnish children in the sixth grade identified 154 children with migraine, 138 with tension-type headache, and 407 children who were headache-free. Seventy children were randomly selected from each group and evaluated by a structured interview to confirm headache type, resulting in a sample of 59 children with migraine, 65 with tension-type headache, and 59 without headache. The children completed the Children's Depression Inventory, and the parents completed the Child Behavior Checklist and General Functioning scale of the McMaster Family Assessment Device. RESULTS Children with migraine had significantly higher levels of total, internalizing, and somatic symptoms, as well as social and family problems, than those without headache and had higher levels of somatic symptoms than children with tension-type headache. Children with tension-type headache had significantly higher levels of somatic symptoms and family problems than those without headache. CONCLUSIONS The association between psychiatric symptoms and headaches shows differences between different headache types. However, a minority of children with migraine or tension-type headache have high levels of psychiatric symptoms.
Neurophysiologic Changes After Preganglionic and Postganglionic Nerve-Root Constriction: An Experimental Study in the Rat

Study Design. We investigated changes in spinal somatosensory-evoked potential (SSEP) and nerve action potential (NAP), correlated behavior, and associated pathologic observation in experimental radiculopathy. Objectives. To create a rat model of sacrococcygeal radiculopathy for determining the validity of SSEP and NAP. Summary of Background Data. We examined the diagnostic sensitivity and value of electrophysiologic tests for evaluating lumbosacral root disease conflict. An appropriate animal model can help verify the value of these tests. Methods. Preganglionic lesion group rats were given 2 loose ligatures around the cauda equina at the sacrum, and postganglionic lesion group rats were given 2 loose ligatures on the conjunction of the sacrococcygeal nerve roots and the caudalis nerve after they had received a laminectomy. Control group rats received a sham operation. SSEPs and NAPs were recorded preligature and postligature, and 3 times after surgery. These electrophysiologic observations were compared and correlated with tail-flick reflex and histology. Results. All experimental group rats developed thermal hyperalgesia on day 14, as indicated by a significant reduction in TFL (tail-flick latency), which continued for 3 months. Amplitude decreased significantly and latency increased significantly in all SSEP recordings immediately after the operation; these changes persisted for 3 months. There were no significant differences between the experimental groups, but there were significant differences between the control and experimental groups. NAP amplitude and latency from the caudalis nerves did not change in any group in the first 2 postoperative weeks. From the second postoperative week until the 3-month follow-up, amplitude was significantly decreased and latency prolonged in the postganglionic group but unchanged in the others. Conclusions. Both SSEP and NAP are useful for evaluating electrophysiologic changes after various radiculopathies. The data also suggest that the conductivity of the peripheral nerve (NAP) was affected by the postganglionic compression of the corresponding nerve root, but not by the preganglionic lesion.
Evolution of the dust emission of massive galaxies up to z=4 and constraints on their dominant mode of star formation

We aim to measure the average dust and molecular gas content of massive star-forming galaxies (>3 × 1010M⊙) up to z = 4 in the COSMOS field to determine if the intense star formation observed at high redshift is induced by major mergers or is caused by large gas reservoirs. Firstly, we measured the evolution of the average spectral energy distributions as a function of redshift using a stacking analysis of Spitzer, Herschel, LABOCA, and AzTEC data for two samples of galaxies: normal star-forming objects and strong starbursts, as defined by their distance to the main sequence. We found that the mean intensity of the radiation field ⟨ U ⟩ heating the dust (strongly correlated with dust temperature) increases with increasing redshift up to z = 4 in main-sequence galaxies. We can reproduce this evolution with simple models that account for the decrease in the gas metallicity with redshift. No evolution of ⟨ U ⟩ with redshift is found in strong starbursts. We then deduced the evolution of the molecular gas fraction (defined here as Mmol/ (Mmol + M⋆)) with redshift and found a similar, steeply increasing trend for both samples. At z ~ 4, this fraction reaches ~60%. The average position of the main-sequence galaxies is on the locus of the local, normal star-forming disks in the integrated Schmidt-Kennicutt diagram (star formation rate versus mass of molecular gas), suggesting that the bulk of the star formation up to z = 4 is dominated by secular processes.
Somatic comorbidity, metabolic syndrome, cardiovascular risk, and CRP in patients with recurrent depressive disorders

Aim To investigate the association between depression, metabolic syndrome (MBS), somatic, particularly cardiovascular comorbidity, and low-grade chronic inflammation assessed using C-reactive protein (CRP). Methods This cross-sectional study included 76 patients with recurrent depressive disorder (RDD) and 72 non-depressed medical staff controls from the Department of Psychiatry, University Hospital Center Zagreb between January 2011 and June 2012. Results Seventy-five percent of patients had somatic comorbidity. The most common comorbid conditions were cardiovascular disorders (46.1%), locomotor system diseases (35.5%), carcinoma (15.8%), thyroid diseases (9.2%), and diabetes (9.2%). MTB was more common in RDD patients (31.6%) than in controls (23.6%), but the difference was not significant. Elevated CRP was found to be significantly more frequent in patients with recurrent depressive disorders (RDD) (35.5%; χ2 test, P = 0.001, Cramer V = 0.29) than in controls (12.5%) and was associated with lowered high-density lipoprotein and overweight/obesity. Conclusion We found some intriguing links between stress, depression, metabolic syndrome, and low grade inflammation, which may be relevant for the prevalence of somatic comorbidity in patients with RDD, but further studies are needed to confirm our results.
Factors predictive of response to cyclosporin treatment for severe, steroid-resistant ulcerative colitis

OBJECTIVE:Cyclosporin-A (CSA) has been demonstrated to be effective for treatment of severe, steroid-resistant ulcerative colitis (UC). Use of CSA has been limited, however, because of low 1-yr response rates and the potential for complications. The aim of this study is to define clinical and laboratory factors predictive of response in severe, steroid-resistant UC.METHODS:A retrospective review of 36 cases of severe, steroid-resistant UC treated with CSA was performed. Intravenous (i.v.) CSA was administered at an initial dose of 2.5 mg/kg, and oral (p.o.) CSA was given as twice the i.v. dose. Clinical response was recorded and logistic regression analysis was performed on clinical and laboratory factors for prediction of response to CSA.RESULTS:Of 36 patients, 25 responded to i.v. CSA and were switched to p.o. CSA. Of the 25, 13 required colectomy by 9 months. The other 12 patients had a sustained response to CSA and avoided colectomy at 9 months. Overall, 24 of 36 patients treated with CSA required colectomy by 9 months. A high percentage of band neutrophils (bands) on admission was found to be a significant predictor of response to CSA.CONCLUSIONS:Bands on admission are predictive of response to CSA and ultimately, the requirement for surgery in steroid-resistant UC.
Identifying and Testing the Inhibitors of Technology Usage Intentions

An important area of information systems (IS) research has been the identification of the individual-level beliefs that enable technology acceptance such as the usefulness, reliability, and flexibility of a system. This study posits the existence of additional beliefs that inhibit usage intentions and thus foster technology rejection rather than acceptance. We theorize that these inhibitors are more than just the antipoles of enablers (e.g., the opposite of usefulness or reliability) and so are distinct constructs worthy of their own investigation. Inhibitors are proposed to have effects on usage intentions beyond that of enablers as well as effects on enablers themselves. We report on a series of empirical studies designed to test the existence and effects of inhibitors. A candidate set of six inhibitors is shown to be distinct from enablers. These inhibitors are subsequently tested in a field study of 387 individuals nested within 32 different websites. Effects at both individual and website unit levels of analysis are tested using multilevel modeling. We find that inhibitors have negative effects on usage intentions, as well as on enablers, and these effects vary contingent upon individual or website unit levels of analysis. The overall results support the existence and importance of inhibitors in explaining individual intent to use---or not use---technology.
Mixing alcohol with energy drink (AMED) and total alcohol consumption: a systematic review and meta‐analysis

It has been suggested that consuming alcohol mixed with energy drink (AMED) may increase total alcohol consumption. Aims of this systematic review and meta‐analysis were (i) to compare alcohol consumption of AMED consumers with alcohol only (AO) consumers (between‐group comparisons), and (ii) to examine if alcohol consumption of AMED consumers differs on AMED and AO occasions (within‐subject comparisons). A literature search identified fourteen studies. Meta‐analyses of between‐group comparisons of N = 5212 AMED consumers and N = 12 568 AO consumers revealed that on a typical single drinking episode AMED consumers drink significantly more alcohol than AO consumers (p = 0.0001, ES = 0.536, 95%CI: 0.349 to 0.724). Meta‐analyses of within‐subject comparisons among N = 2871 AMED consumers revealed no significant difference in overall alcohol consumption on a typical drinking episode between AMED and AO occasions (p = 0.465, ES = −0.052, 95%CI: −0.192 to 0.088). In conclusion, between‐group comparisons suggest that heavy alcohol consumption is one of the several phenotypical differences between AMED and AO consumers. Within‐subject comparisons revealed, however, that AMED consumption does not increase the total amount of alcohol consumed on a single drinking episode. © 2016 The Authors. Human Psychopharmacology: Clinical and Experimental Published by John Wiley & Sons Ltd
Deletion of TRIM32 protects mice from anxiety‐ and depression‐like behaviors under mild stress

Chronic stress causes a variety of psychiatric disorders such as anxiety and depression, but its mechanism is not well understood. Tripartite motif‐containing protein 32 (TRIM32) was strongly associated with autism spectrum disorder, attention deficit hyperactivity disorder, anxiety and obsessive compulsive disorder based on a study of copy number variation, and deletion of TRIM32 increased neural proliferation and reduced apoptosis. Here, we propose that TRIM32 is involved in chronic stress‐induced affective behaviors. Using a chronic unpredictable mild stress mouse depression model, we studied expression of TRIM32 in brain tissue samples and observed behavioral changes in Trim32 knockout mice. The results showed that TRIM32 protein but not its mRNA was significantly reduced in hippocampus in a time‐dependent manner within 8 weeks of chronic stress. These stress‐induced affective behaviors and reduction of TRIM32 protein expression were significantly reversed by antidepressant fluoxetine treatment. In addition, Trim32 knockout mice showed reduced anxiety and depressive behaviors and hyperactivities compared with Trim32 wild‐type mice under normal and mild stress conditions. We conclude that TRIM32 plays important roles in regulation of hyperactivities and positively regulates the development of anxiety and depression disorders induced by chronic stress.
Model characterization curves for federated search using click-logs: predicting user engagement metrics for the span of feasible operating points

Modern day federated search engines aggregate heterogeneous types of results from multiple vertical search engines and compose a single search engine result page (SERP). The search engine aggregates the results and produces one ranked list, constraining the vertical results to specific slots on the SERP. The usual way to compare two ranking algorithms is to first fix their operating points (internal thresholds), and then run an online experiment that lasts multiple weeks. Online user engagement metrics are then compared to decide which algorithm is better. However, this method does not characterize and compare the behavior over the entire span of operating points. Furthermore, this time-consuming approach is not practical if we have to conduct the experiment over numerous operating points. In this paper we propose a method of characterizing the performance of models that allows us to predict answers to "what if" questions about online user engagement using click-logs over the entire span of feasible operating points. We audition verticals at various slots on the SERP and generate click-logs. This log is then used to create operating curves between variables of interest (for example between result quality and click-through). The operating point for the system then can be chosen to achieve a specific trade-off between the variables. We apply this methodology to predict i) the online performance of two different models, ii) the impact of changing internal quality thresholds on clickthrough, iii) the behavior of introducing a new feature, iv) which machine learning loss function will give better online engagement, v) the impact of sampling distribution of head and tail queries in the training process. The results are reported on a well-known federated search engine. We validate the predictions with online experiments.
Characterization of endocytic compartments using the horseradish peroxidase-diaminobenzidine density shift technique

We have employed a modification of the horseradish peroxidase (HRP)- diaminobenzidine density shift technique of Courtoy et al. (J. Cell Biol., 1984, 98:870-876) to examine the biochemical properties of the endosome. This organelle is involved in receptor recycling and the sorting of internalized receptor ligand complexes. Transferrin covalently bound to HRP was used to place peroxidase activity specifically within the endosome. The peroxidase-catalyzed polymerization of diaminobenzidine within these vesicles causes an increase in buoyant density, thus allowing them to be separated from other membranes. Using this technique we demonstrate that 125I-low density lipoprotein, 131I-epidermal growth factor, and Tf-HRP are internalized into the same endosome. We discovered that the diaminobenzidine reaction product "cross-links" the lumen of the vesicle, rendering vesicular components detergent insoluble. Furthermore, the reaction inactivates enzymatic activities associated with the endosome. Thus, the diaminobenzidine density shift procedure has limited usefulness in studies designed to isolate endosomal constituents. Nonetheless, we have found that the inactivation of enzymatic activities is confined to those endosomes that contain peroxidase. This selectivity allows us to define endosome-specific activities.
Alcohol consumption and survival of colorectal cancer patients : population-based study from Germany 1 , 2

Background: Studies on the association between alcohol consumption and colorectal cancer (CRC) prognosis have yielded inconsistent results. Objective: The associations of lifetime and 1-y prediagnostic alcohol consumption with relevant prognostic outcomes were evaluated in a large population-based cohort of CRC patients. Design: In 2003–2010, 3121 patients diagnosed with CRC were interviewed on sociodemographic and lifestyle factors, medication, and comorbidities. Cancer recurrence, vital status, and cause of death were documented for a median follow-up time of 4.8 y. With the use of Cox proportional hazard regression, associations between lifetime and recent alcohol consumption and overall, CRC-specific, recurrence-free, and disease-free survival were analyzed. Results: In this patient cohort with a median age of 69 y at diagnosis, lifetime abstainers showed poorer overall [adjusted HR (aHR): 1.25; 95% CI: 1.03, 1.52] and CRC-specific (aHR: 1.37; 95% CI: 1.10, 1.70) survival than lifetime light drinkers (women: .0–12 g/d; men: .0–24 g/d). Lifetime heavy drinkers showed poorer overall (aHR: 1.37; 95% CI: 1.06, 1.78) and disease-free (aHR: 1.38; 95% CI: 1.09, 1.74) survival. Alcohol abstaining in the year before diagnosis was associated with poorer overall (aHR: 1.42; 95% CI: 1.20, 1.68), CRC-specific (aHR: 1.38; 95% CI: 1.13, 1.68), and disease-free (aHR: 1.23; 95% CI: 1.05, 1.44) survival. Lifetime abstainers with nonmetastatic disease showed poorer CRC-specific (aHR: 1.48; 95% CI: 1.10, 2.00) and recurrence-free (aHR: 1.32; 95% CI: 1.02, 1.70) survival. Wine abstaining but not beer or liquor abstaining was associated with poorer survival. Associations between alcohol consumption and prognosis varied according to presence of diabetes and age. Conclusions: Prediagnostic alcohol abstaining and heavy drinking were associated with poorer survival after a CRC diagnosis than light drinking. The protective effects of light consumption might be restricted to wine, and associations might differ according to age and presence of diabetes mellitus. Am J Clin Nutr doi: 10.3945/ajcn.115. 127092.
MRI-guided adaptive radiotherapy in locally advanced cervical cancer from a Nordic perspective

Abstract Background. The first Nordic protocol for three-dimensional (3D) planned radiotherapy in locally advanced cervical cancer was the prospective NOCECA study (1994–2000). NOCECA consisted of computed tomography (CT)-based 3D conformal external beam radiotherapy (EBRT) with a simultaneous integrated boost (SIB) to the primary tumour combined with brachytherapy (BT) based on x-ray imaging. In NOCECA the planning aim was to achieve 80 Gy at point A from EBRT and BT combined. However, the balance of dose between EBRT and BT was determined by tumour size at diagnosis with more EBRT dose given to point A and less by BT in more advanced stages. In 2005 image-guided adaptive brachytherapy (IGABT) based on magnetic resonance imaging (MRI) and optimisation of the BT dose distribution to the remaining tumour and cervix at time of BT (HR CTV) was introduced in Aarhus. EBRT remained like in NOCECA until 2008 when the SIB to the primary tumour was abandoned and IMRT was introduced as routine technique. In this study, we report outcome of our first five-year experience with IGABT using our NOCECA cohort as reference. Material and methods. The NOCECA cohort comprising 99 patients was compared with 140 consecutive patients treated by IGABT. Patients with para-aortic nodes were excluded in NOCECA but were present in 9% of the patients treated with IGABT. No patient in NOCECA received chemotherapy whereas concomitant cisplatin was given to 79% of the IGABT patients. Results. With IGABT actuarial local control was 91% at three years. When comparing NOCECA with IGABT overall survival was significantly improved from 63% to 79% (p = 0.005). In parallel, both moderate and severe late morbidity were reduced by about 50% (p = 0.02). Conclusion. Introduction of IGABT reduced morbidity and generated a very high rate of local control, which likely has improved survival by at least as much as concomitant chemotherapy.
The ARL monopod II running robot: control and energetics

This paper presents the experimental implementation of an energy efficient "controlled passive dynamic running" strategy on a planar one-legged running robot with hip and leg compliance. We (1997) introduced the approach previously via simulations, and tested via preliminary experiments. The improved version described here permits running speed of up to 4.5 km/h with a total mechanical power expenditure of only 48 W, which translates into a specific resistance of only 0.22. This is the highest efficiency among all actively controlled legged robots.