Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving Hole Cleaning Efficiency using Nanosilica in Water-Based Drilling Mud

Inadequate wellbore cleaning contributes to several major drilling problems such as; increase in torque and drag that can limit the reach to target, mechanical pipe sticking, difficulties in casing and cementing and logging operations that can increase well cost significantly. Meanwhile, effective removal of drilled cuttings from the wellbore improves penetration rate and drilling efficiency. Herein, water-based mud was formulated with nanosilica to enhance cuttings and solid particles transport from the wellbore to the surface. Four different weight percent concentrations of nanosilica (0.001, 0.003, 0.005 and 0.01 wt.%) at three different flow rates in litres/seconds (0.4, 0.6 and 1.0) and cutting size (small, medium and large) were used to investigate the formulated water-based mud lifting capacity of the drilled cuttings and other solid particles. Thereafter, the hole cleaning efficiency of the water-based mud containing nanosilica was compared to conventional water-based mud. The results show that nanosilica water-based mud influences the cuttings lifting capacity. The addition of the nanosilica concentrations to the water-based mud enhances the viscosity, thereby increasing the muds carrying and circulating capacity. Moreover, nanosilica water-based mud displays mud stability that will stabilize the wellbore and prevent the intrusion of formation fluids into it when compared with the conventinal water-based mud. The effect of cuttings size on the wellbore cleaning is minimal. The large cuttings size shows a lower degree of cuttings transportation compared with the small and medium cutting size. The small cuttings size has higher cuttings recovery to the surface. Finally, though increase in flowrate leads to more cuttings recovery, there is every tendency that much fluid flow rate will cause an increase in frictional pressure losses and equivalent circulating density, high pump pressure requirement and potential hole erosion.
Manipulation of ellipsoidal nanoparticles considering roughness based on atomic force microscopy

The contribution in this paper is to investigate the manipulation of ellipsoidal nanoparticles by atomic force microscopy, taking into consideration of roughness. For the first phase of manipulation, roughness was investigated just for the substrate, but for the second phase, it begins by particle movement substrate and particle roughness is considered. The particle is of gold material; moreover, tip and substrate are made of silicon. Having examined the effective parameters of the contact mechanics, including the indentation depth and contact area for the Hertz, Jamari and Jeng–Wang models, two Jamari and Jeng–Wang contact models were used to consider the particle–probe contact and the particle–substrate contact respectively. By these two models, the first phase of manipulation process is simulated. At the end of this step, the force and the time, by which the particle starts moving, are detected. The next phase of manipulation begins with particle movement initiation and ends when it reaches the target point, which is called the second phase of manipulation. In order to simulate the second phase of manipulation, the Wilson model is used. Also, due to the fact that no surface is completely smooth and it has roughness that affects the amount of friction force and consequently manipulation relations, in order to bring the results closer to reality, in this article the Rumpf and Rabinovich models are used. In the first phase of manipulation for modelling the substrate roughness, Rumpf and Rabinovich models are used. Moreover, Rumpf model is used for modelling the particle and substrate roughness in the second phase of manipulation. Finally, to validate the results of the manipulation simulation process, they are compared with the results of the existing researches. In the first phase of the manipulation, based on the simulation results, the critical time and force error for the sliding mode were 0.94 and 1.1%, respectively. Meanwhile, the critical time and force error for rotation mode are 1.3 and 1.7%, respectively. For manipulation, taking roughness into account, the critical time and force error for sliding and rotation modes in the first phase of manipulation are about 6%. The error for the second phase, using Wilson model, considering roughness for the particle and the substrate when the particle slides on the substrate is 3.2% as well. As a result, there is a good match between the simulation and the experimental results for both manipulation phases.
Measuring document image skew and orientation

Several approaches have previously been taken for identifying document image skew. At issue are efficiency, accuracy, and robustness. We work directly with the image, maximizing a function of the number of ON pixels in a scanline. Image rotation is simulated by either vertical shear or accumulation of pixel counts along sloped lines. Pixel sum differences on adjacent scanlines reduce isotropic background noise from non-text regions. To find the skew angle, a succession of values of this function are found. Angles are chosen hierarchically, typically with both a coarse sweep and a fine angular bifurcation. To increase efficiency, measurements are made on subsampled images that have been pre-filtered to maximize sensitivity to image skew. Results are given for a large set of images, including multiple and unaligned text columns, graphics, and large area halftones. The measured intrinsic angular error is inversely proportional to the number of sampling points on a scanline. This method does not indicate when text is upside-down, and it also requires sampling the function at 90 degrees of rotation to measure text skew in landscape mode. However, such text orientation can be determined (as one of four directions) by noting that Roman characters in all languages have many more ascenders than descenders, and using morphological operations to identify such pixels. Only a small amount of text is required for accurate statistical determination of orientation, and images without text are identified as such.
Effect of Grain Size and Mineral Mixing on Carbonate Absorption Features in the SWIR and TIR Wavelength Regions

Reflectance spectra of carbonate minerals in the shortwave infrared (SWIR) and thermal infrared (TIR) wavelength regions contain a number of diagnostic absorption features. The shape of these features depends on various physical and chemical parameters. To accurately identify carbonate minerals or rocks in pure and mixed form, it is necessary to analyze the effects of the parameters on spectral characteristics. In this study, we analyzed spectral absorption feature characteristics of calcite and dolomite in the SWIR (features at 2.3 and 2.5 μm) and TIR (features at 11.5 and 14 μm) wavelength regions, as a function of grain size and carbonate mineral mixtures. Results showed that varying grain sizes and mineral contents in the sample, influence reflectance values and absorption feature characteristics. Absorption band positions of pure and mixed calcite and dolomite in the SWIR and TIR regions for both features were displaced slightly as observed in previous studies. The band positions of calcite and dolomite varied relative to grain size only in the TIR region. These positions shifted to longer wavelengths for the feature at 11.5 μm and to shorter wavelengths for the feature at 14 μm from fine to coarse grain size. The band positions of calcite-dolomite mixtures in the SWIR and TIR regions were determined by the quantity of calcite and dolomite in the sample. These results can be applied for the identification of pure and mixed calcite and dolomite, as well as estimating the relative abundance of both minerals with different grain size and mineral mixtures in a synthetic sample or rock. They can also be used as a preliminary proxy for assessing dolomitization patterns in carbonate rocks.
A Comparable Study of Combinational Regenerative Therapies Comprising Enamel Matrix Derivative plus Deproteinized Bovine Bone Mineral with or without Collagen Membrane in Periodontitis Patients with Intrabony Defects

Aim: The aim of the present study was to examine the effectiveness of collagen membrane (CM) in regenerative therapy with deproteinized bovine bone mineral (DBBM) and enamel matrix derivative (EMD) for periodontal intrabony defects. Methods: Eighteen periodontal intrabony defects of nine chronic periodontitis patients were evaluated. Two defects per patient with probing pocket depth (PPD) ≥ 6 mm were assigned to two different types of treatments: EMD + DBBM + CM or EMD + DBBM. Clinical parameters including Gingival Index (GI), PPD, clinical attachment level (CAL), gingival recession (GR), bleeding on probing (BOP), tooth mobility (MOB), and the filled bone volume/rate (FBV/FBR), which was measured by cone beam computed tomography, were compared at baseline and 12 months post-treatment. Differences between groups were determined by the chisquare test, McNemar’s test, and Wilcoxon signed-rank test. Results: Clinically, PPD, CAL, and FBR significantly improved in both groups (p < 0.05). The between-group comparison showed that the EMD + DBBM + CM group resulted in slightly greater PPD reduction, CAL gain, and FBR; however, these differences were not statistically significant. Conclusion: Periodontal regenerative therapies comprising EMD and DBBM with and without CM resulted in positive clinical outcomes. The use of CM may result in better outcomes in MOB decrease; however, long-term prognosis must be further studied.
Weight loss and body composition changes following three sequential cycles of ketogenic enteral nutrition

Background: Ketogenic enteral nutrition (KEN) is a modification of the protein sparing modified fast in which a protein solution is introduced with a continuous infusion through a nasogastric tube over 10-days cycles. The aim of the study was to perform a retrospective analysis of the safety, compliance, weight loss and body composition changes after 3 sequential 10-days cycles of KEN therapy. Materials and Methods: From a large number of patients who underwent KEN therapy in our department over a 5-year period, we selected 188 patients who participated in 3 KEN cycles with 10-13 days of break between them. Before and after the treatment cycles, body composition was analyzed by bioelectric impedance; a final assessment was made 10 days after the end of last cycle. During each rest period all the patients were on a low-carbohydrate, normal caloric diet. Results: Most patients (97%) successfully tolerated the nasogastric treatment and lost an average of 14.4 kg of body weight, 10.6 kg of fat mass and 3.4 kg of body cell mass. Adverse effects were recorded as mild gastric hypersecretion (2%) and constipation (5%). Patients continued to lose fat during the 10-day follow up period after the end of each KEN Cycle. This effect may be explained by abnormality of water distribution during the rapid weight loss inducing the observed change in fat mass. Conclusion: Ten-days KEN treatment cycles can induce rapid weight loss and reduction of fat mass in obese patients. Furthermore, preservation of lean mass can be achieved by infusing 1.9 g of protein/kg of BCM.
Conceptual scoring of receptive and expressive vocabulary measures in simultaneous and sequential bilingual children.

PURPOSE The authors examined the effects of conceptual scoring on the performance of simultaneous and sequential bilinguals on standardized receptive and expressive vocabulary measures in English and Spanish. METHOD Participants included 40 English-speaking monolingual children, 39 simultaneous Spanish-English bilingual children, and 19 sequential bilingual children, ages 5-7. The children completed standardized receptive and expressive vocabulary measures in English and also in Spanish for those who were bilingual. After the standardized administration, bilingual children were given the opportunity to respond to missed items in their other language to obtain a conceptual score. RESULTS Controlling for group differences in socioeconomic status (SES), both simultaneous and sequential bilingual children scored significantly below monolingual children on single-language measures of English receptive and expressive vocabulary. Conceptual scoring removed the significant difference between monolingual and simultaneous bilingual children in the receptive modality but not in the expressive modality; differences remained between monolingual and sequential bilingual children in both modalities. However, in both bilingual groups, conceptual scoring increased the proportion of children with vocabulary scores within the average range. CONCLUSION Conceptual scoring does not fully ameliorate the bias inherent in single-language standardized vocabulary measures for bilingual children, but the procedures employed here may assist in ruling out vocabulary deficits, particularly in typically developing simultaneous bilingual children.
Star formation in Perseus III. Outflows

Context. We present a search for outflows towards 51 submillimetre cores in the Perseus molecular cloud. Aims. Our first objective is to identify the protostellar population through the detection of molecular outflows. Our second aim is to consistently derive outflow properties from a large homogeneous dataset within one molecular cloud in order to investigate further the mass dependence and time evolution of protostellar mass loss. Methods. We used the James Clerk Maxwell Telescope to map $2'$ $\times$ $2'$ regions around each core in 12 CO 3–2. Where molecular outflows were detected we derived momentum fluxes. Results. Of the 51 cores, 37 show broad linewings indicative of molecular outflows. In 13 cases, the linewings could be due to confusion with neighbouring flows but 9 of those sources also have near-infrared detections confirming their protostellar nature. The total fraction of protostars in our sample is 65%. All but four outflow detections are confirmed as protostellar by Spitzer IR detections and only one Spitzer source has no outflow, showing that outflow maps at this sensitivity are equally good at identifying protostars as Spitzer. Outflow momentum flux correlates both with source luminosity and with core mass but there is considerable scatter even within this one cloud despite the homogeneous dataset. We fail to confirm the result of Bontemps et al. (1996) that Class I sources show lower momentum fluxes on average than Class 0 sources, with a KS test showing a significant probability that the momentum fluxes for both Class 0s and Class Is are drawn from the same distribution. Conclusions. We find that outflow power may not show a simple decline between the Class 0 to Class I stages. Our sample includes low momentum flux, low-luminosity Class 0 sources, possibly at a very early evolutionary stage. If the only mass loss from the core were due to outflows, cores would last for 10 5 –10 8 years, longer than current estimates of 1.5–4 $\times$ 10 5 years for the mean lifetime for the embedded phase. Additional mechanisms for removing mass from protostellar cores may be necessary.
Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.

BACKGROUND We reviewed systematically the results of genetic studies investigating associations between putative susceptibility genes for attention-deficit hyperactivity disorder (ADHD) and neuropsychological traits relevant for this disorder. METHODS We identified papers for review through the PubMed database. RESULTS Twenty-nine studies examined 10 genes (DRD4, DAT1, COMT, DBH, MAOA, DRD5, ADRA2A, GRIN2A, BDNF and TPH2) in relation to neuropsychological traits relevant for ADHD. For DRD4, the continuous performance test (CPT) and derived tasks were the most used tests. Association of high reaction time variability with the 7-repeat allele absence appears to be the most consistent result and seems to be specific to ADHD. Speed of processing, set-shifting and cognitive impulsiveness were less frequently investigated but seem to be altered in the 7-repeat allele carriers. No effect of genotype was found on response inhibition (the stop and go/no-go tasks). For DAT1, 4 studies provide conflicting results in relation to omission and commission errors from CPT and derived tasks. High reaction time variability seems to be the most replicated cognitive marker associated with the 10-repeat homozygosity. The other genes have attracted fewer studies, and the reported findings need to be replicated. LIMITATIONS Although we aimed to perform a formal meta-analysis, this was not possible because the number of studies using the same neurocognitive endophenotypes was limited. We referred only minimally to the various theoretical frameworks in this field of research; more detail would have been beyond the scope of our systematic review. Finally, sample sizes in most of the studies we reviewed were small. Thus, some negative findings could be attributed to a lack of statistical power, and positive results should be considered preliminary until they are replicated in extended samples. CONCLUSION Several methodological issues, including measurement errors, developmental changes in cognitive abilities, sex, psychostimulant effects and presence of comorbid conditions, represent confounding factors and may explain conflicting results.
Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults

To evaluate the impact of reduced radiation and combined modality therapy (CMT) in the treatment of Hodgkin lymphoma, we assessed the risk of second malignant neoplasms (SMNs) in patients who received extended‐field radiotherapy only and patients who underwent CMT. Among 404 patients treated at Yale during 1970–2004, the risk of solid SMNs was elevated in the radiotherapy only group (n = 198, median follow‐up = 21·1 years) compared to the general population, with a standardized incidence ratio (SIR) of 1·85 [95% confidence interval (CI): 1·17–2·78]. No increase was observed in the CMT group (n = 206, median follow‐up = 14·3 years), although potential differences in SMN risk were indicated across the age spectrum in subgroup analysis. Patients who received mustard‐containing regimens had increased risks for haematological SMNs (SIR = 8·74) and all SMNs (SIR = 1·85). When the analysis was stratified by age at diagnosis, children (0–20 years) had a significantly higher risk of SMNs (SIR = 5·24, 95% CI: 2·26–10·33), regardless of the treatment received. These findings suggest that recent treatment options utilizing lower dose radiation and less intense alkylator chemotherapy might be associated with lower incidences of SMNs among adults but not necessarily children.
METABOLIC ADAPTATION IN INDIGENOUS SIBERIAN POPULATIONS

AbstractPrevious research has suggested that arctic populations have elevated metabolic rates in response to their cold, marginal climate. Recent studies of indigenous Siberian groups have confirmed these earlier findings and have shed light on the mechanisms through which northern populations adapt to their environments. Indigenous Siberians show significant elevations in basal metabolic rate compared with reference values. Total energy expenditure is variable across Siberian groups and is correlated with levels of acculturation. Siberian populations appear to have adapted to cold stress through both short-term acclimatization and genetic adaptations, with thyroid hormones playing an important role in shaping metabolic responses. Elevated metabolic rates also have important consequences for health and may contribute to the low serum lipid levels observed in Siberian groups. Further research is needed to elucidate the underlying mechanisms of metabolic adaptation and their implications for ongoing health .
Measurement and Meaning of Oxidatively Modified DNA Lesions in Urine

Background: Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide variety of diseases. The noninvasive assessment of such damage, i.e., in urine, and application to large-scale human studies are vital to understanding this role and devising intervention strategies. Methods: We have reviewed the literature to establish the status quo with regard to the methods and meaning of measuring DNA oxidation products in urine. Results: Most of the literature focus upon 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), and whereas a large number of these reports concern clinical conditions, there remains (a) lack of consensus between methods, (b) possible contribution from diet and/or cell death, (c) no definitive DNA repair source of urinary 2′-deoxyribonucleoside lesions, and (d) no reference ranges for healthy or diseased individuals. Conclusions: The origin of 8-oxodG is not identified; however, recent cell culture studies suggest that the action of Nudix hydrolase(s) on oxidative modification of the nucleotide pool is a likely candidate for the 8-oxodG found in urine and, potentially, of other oxidized 2′-deoxyribonucleoside lesions. Literature reports suggest that diet and cell death have minimal, if any, influence upon urinary levels of 8-oxodG and 8-oxo-7,8-dihydroguanine, although this should be assessed on a lesion-by-lesion basis. Broadly speaking, there is consensus between chromatographic techniques; however, ELISA approaches continue to overestimate 8-oxodG levels and is not sufficiently specific for accurate quantification. With increasing numbers of lesions being studied, it is vital that these fundamental issues are addressed. We report the formation of the European Standards Committee on Urinary (DNA) Lesion Analysis whose primary goal is to achieve consensus between methods and establish reference ranges in health and disease. (Cancer Epidemiol Biomarkers Prev 2008;17(1):3–14)
NEW COMBINATION SUPPOSITORIES OF LORNOXICAM AND ALOIN FOR RHEUMATOID ARTHRITIS

Â Â Objective: The objective of our current work is to formulate, optimize and evaluate new combination rectal suppositories as a treatment for rheumatoid arthritis that contains both lornoxicam and aloin. Both are strong anti-inflammatory agents, and a combination of both may have synergistic effect as an anti-inflammatory treatment.Methods: Rectal suppositories containing 8 mg lornoxicam and 200 mg aloin were formulated by heat fusion method. Different combinations of different molecular weights of polyethylene glycol (PEG) were used for the formulated suppositories. The formulated suppositories were evaluated for their visual appearance, weight variation, hardness, friability, disintegration time, melting temperature, and drug content uniformity.Results: All the formulations prepared were within the required limits for USP. When the release study was performed, both drugs were released from all the formulations prepared. However, formulation F7 which is composed of PEG 400 30.88% (w/w): PEG 4000 46.32% (w/w) was superior to other formulations in which more than 80% of both drugs loaded were released after 35 min. The presence of both drugs in the same suppository did not affect their release.Conclusion: A new combination suppositories have been obtained where the two combined drugs were released fast without interference with each other release. The proposed new combination has the potential to be used as a strong analgesic and anti-inflammatory treatment compared to using lornoxicam or aloin alone.
A new approach to hyperbolic inverse problems II: global step

We study the inverse problem for the second-order self-adjoint hyperbolic equation with the boundary data given on a part of the boundary. This paper is the continuation of the author's paper (Eskin 2006 A new approach to hyperbolic inverse problems Inverse Problems 22 815–33), in which we presented the crucial local step of the proof. In this paper, we prove the global step. Our method is a modification of the BC method with some new ideas. In particular, the method of determination of the metric is new.