Miracle-dz/UniFAR-FTUs huggingface dataset:
Separating Fusion from Rivalry

Visual fusion is the process in which differing but compatible binocular information is transformed into a unified percept. Even though this is at the basis of binocular vision, the underlying neural processes are, as yet, poorly understood. In our study we therefore aimed to investigate neural correlates of visual fusion. To this end, we presented binocularly compatible, fusible (BF), and incompatible, rivaling (BR) stimuli, as well as an intermediate stimulus type containing both binocularly fusible and monocular, incompatible elements (BFR). Comparing BFR stimuli with BF and BR stimuli, respectively, we were able to disentangle brain responses associated with either visual fusion or rivalry. By means of functional magnetic resonance imaging, we measured brain responses to these stimulus classes in the visual cortex, and investigated them in detail at various retinal eccentricities. Compared with BF stimuli, the response to BFR stimuli was elevated in visual cortical areas V1 and V2, but not in V3 and V4 – implying that the response to monocular stimulus features decreased from V1 to V4. Compared to BR stimuli, the response to BFR stimuli decreased with increasing eccentricity, specifically within V3 and V4. Taken together, it seems that although the processing of exclusively monocular information decreases from V1 to V4, the processing of binocularly fused information increases from earlier to later visual areas. Our findings suggest the presence of an inhibitory neural mechanism which, depending on the presence of fusion, acts differently on the processing of monocular information.
Machine Learning from Concept to Clinic: Reliable Detection of BRAF V600E DNA Mutations in Thyroid Nodules Using High-Dimensional RNA Expression Data

The promise of personalized medicine will require rigorously validated molecular diagnostics developed on minimally invasive, clinically relevant samples. Measurement of DNA mutations is increasingly common in clinical settings but only higher-prevalence mutations are cost-effective. Patients with rare variants are at best ignored or, at worst, misdiagnosed. Mutations result in downstream impacts on transcription, offering the possibility of broader diagnosis for patients with rare variants causing similar downstream changes. Use of such signatures in clinical settings is rare as these algorithms are difficult to validate for commercial use. Validation on a test set (against a clinical gold standard) is necessary but not sufficient: accuracy must be maintained amidst interfering substances, across reagent lots and across operators. Here we report the development, clinical validation, and diagnostic accuracy of a pre-operative molecular test (Afirma BRAF) to identify BRAF V600E mutations using mRNA expression in thyroid fine needle aspirate biopsies (FNABs). FNABs were obtained prospectively from 716 nodules and more than 3,000 features measured using microarrays. BRAF V600E labels for training (n=181) and independent test (n=535) sets were established using a sensitive quantitative PCR (qPCR) assay. The resulting 128-gene linear support vector machine was compared to qPCR in the independent test set. Clinical sensitivity and specificity for malignancy were evaluated in a subset of test set samples (n=213) with expert-derived histopathology. We observed high positive- (PPA, 90.4%) and negative (NPA, 99.0%) percent agreement with qPCR on the test set. Clinical sensitivity for malignancy was 43.8% (consistent with published prevalence of BRAF V600E in this neoplasm) and specificity was 100%, identical to qPCR on the same samples. Classification was accurate in up to 60% blood. A double-mutant still resulting in the V600E amino acid change was negative by qPCR but correctly positive by Afirma BRAF. Non-diagnostic rates were lower (7.6%) for Afirma BRAF than for qPCR (24.5%), a further advantage of using RNA in small sample biopsies. Afirma BRAF accurately determined the presence or absence of the BRAF V600E DNA mutation in FNABs, a collection method directly relevant to solid tumor assessment, with performance equal to that of an established, highly sensitive DNA-based assay and with a lower non-diagnostic rate. This is the first such test in thyroid cancer to undergo sufficient analytical and clinical validation for real-world use in a personalized medicine context to frame individual patient risk and inform surgical choice.
The Effects of Ethnicity and Culturally Congruent and Incongruent Nonverbal Behaviors on Interpersonal Attraction1

The study investigated the effects of ethnicity and nonverbal style on interpersonal attraction in university students. Sixty-four Palagi (white New Zealand) women participated in the research and were randomly assigned to interview either a Palagi or Samoan student in a study on friendship. Female confederates, who posed as interviewees, responded with a pre-rehearsed script and exhibited either a Palagi or Samoan nonverbal style. After conclusion of the interview, subjects completed a questionnaire about the project, including their perceptions of the interviewee confederate. A2 × 2 analysis of variance revealed a main effect of nonverbal style on ratings of interpersonal attractiveness: subjects preferred confederates who displayed culturally congruent (Palagi) nonverbal behaviors. There were no significant effects, however, for ethnicity or for the ethnicity by style interaction.
An Identity-Free and On-Demand Routing Scheme against Anonymity Threats in Mobile Ad Hoc Networks

Introducing node mobility into the network also introduces new anonymity threats. This important change of the concept of anonymity has recently attracted attentions in mobile wireless security research. This paper presents identity-free routing and on- demand routing as two design principles of anonymous routing in mobile ad hoc networks. We devise ANODR (ANonymous On-Demand Routing) as the needed anonymous routing scheme that is compliant with the design principles. Our security analysis and simulation study verify the effectiveness and efficiency of ANODR.
Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment

Background: Neutrophil-gelatinase associated lipocalin (NGAL), a tubular injury marker, is associated with iron metabolism in hemodialysis patients. We investigated whether serum NGAL levels reflect iron metabolism in combined chronic heart failure and chronic kidney disease (CHF/CKD) and whether treatment with low-dose erythropoietin stimulating agent (ESA) modulates NGAL levels. Methods: In the EPOCARES trial (ClinTrialsNCT00356733) serum NGAL, hepcidin-25, transferrin saturation (TSAT), reticulocyte hemoglobin content (Ret-He) and endogenous erythropoietin (EPO) levels were measured. Results: Baseline serum NGAL levels correlated with cystatin C (r=0.767, p<0.001) and baseline EPO levels (r=-0.395, p=0.003). There was no correlation with baseline TSAT, Ret-He, and hepcidin-25 levels. After two weeks, NGAL levels decreased in the ESA-group (p=0.02), while there was no change in the no-ESA group (p=0.62). The magnitude in NGAL decrease in the ESA-group correlated with baseline EPO levels (r=0.431, p=0.01). Conclusions: In contrast to in HD patients, in combined CKD/ CHF, serum NGAL levels did not correlate with iron metabolism, hence NGAL might reflect tubular damage in these patients. NGAL levels inversely correlated with baseline EPO levels and decreased in response to short-term ESA treatment, which might reflect an effect of ESA on tubular damage. These findings need to be confirmed and alternative explanations should be evaluated.
From Queer to Gay and Back Again: Young Adult Novels with Gay/Lesbian/Queer Content, 1969-1997

Approximately one hundred young adult novels with gay/lesbian/queer content have been published since the first one appeared in 1969. Building on earlier content analysis research, this article provides three theoretical approaches to understand the evolution of this subgenre, drawing on the work of Gerda Lerner, Rudine Sims Bishop, and George Chauncey. It concludes by highlighting themes and patterns that suggest the progress that has been made and has yet to be made in the realistic portrayal of gay/lesbian/queer lives in young adult fiction.
An empirical stochastic model of sea-surface temperatures and surface winds over the Southern Ocean

Abstract. This study employs NASA's recent satellite measurements of sea-surface temperatures (SSTs) and sea-level winds (SLWs) with missing data filled-in by Singular Spectrum Analysis (SSA), to construct empirical models that capture both intrinsic and SST-dependent aspects of SLW variability. The model construction methodology uses a number of algorithmic innovations that are essential in providing stable estimates of the model's propagator. The best model tested herein is able to faithfully represent the time scales and spatial patterns of anomalies associated with a number of distinct processes. These processes range from the daily synoptic variability to interannual signals presumably associated with oceanic or coupled dynamics. Comparing the simulations of an SLW model forced by the observed SST anomalies with the simulations of an SLW-only model provides preliminary evidence for the ocean driving the atmosphere in the Southern Ocean region.
Organic Farming: Biodiversity Impacts Can Depend on Dispersal Characteristics and Landscape Context

Organic farming, a low intensity system, may offer benefits for a range of taxa, but what affects the extent of those benefits is imperfectly understood. We explored the effects of organic farming and landscape on the activity density and species density of spiders and carabid beetles, using a large sample of paired organic and conventional farms in the UK. Spider activity density and species density were influenced by both farming system and surrounding landscape. Hunting spiders, which tend to have lower dispersal capabilities, had higher activity density, and more species were captured, on organic compared to conventional farms. There was also evidence for an interaction, as the farming system effect was particularly marked in the cropped area before harvest and was more pronounced in complex landscapes (those with little arable land). There was no evidence for any effect of farming system or landscape on web-building spiders (which include the linyphiids, many of which have high dispersal capabilities). For carabid beetles, the farming system effects were inconsistent. Before harvest, higher activity densities were observed in the crops on organic farms compared with conventional farms. After harvest, no difference was detected in the cropped area, but more carabids were captured on conventional compared to organic boundaries. Carabids were more species-dense in complex landscapes, and farming system did not affect this. There was little evidence that non-cropped habitat differences explained the farming system effects for either spiders or carabid beetles. For spiders, the farming system effects in the cropped area were probably largely attributable to differences in crop management; reduced inputs of pesticides (herbicides and insecticides) and fertilisers are possible influences, and there was some evidence for an effect of non-crop plant species richness on hunting spider activity density. The benefits of organic farming may be greatest for taxa with lower dispersal abilities generally. The evidence for interactions among landscape and farming system in their effects on spiders highlights the importance of developing strategies for managing farmland at the landscape-scale for most effective conservation of biodiversity.
Generating Bulk-Scale Ordered Optical Materials Using Shear-Assembly in Viscoelastic Media

We review recent advances in the generation of photonics materials over large areas and volumes, using the paradigm of shear-induced ordering of composite polymer nanoparticles. The hard-core/soft-shell design of these particles produces quasi-solid “gum-like” media, with a viscoelastic ensemble response to applied shear, in marked contrast to the behavior seen in colloidal and granular systems. Applying an oscillatory shearing method to sub-micron spherical nanoparticles gives elastomeric photonic crystals (or “polymer opals”) with intense tunable structural color. The further engineering of this shear-ordering using a controllable “roll-to-roll” process known as Bending Induced Oscillatory Shear (BIOS), together with the interchangeable nature of the base composite particles, opens potentially transformative possibilities for mass manufacture of nano-ordered materials, including advances in optical materials, photonics, and metamaterials/plasmonics.
Psychosocial Factors Affecting Smartphone Addiction in University Students

Abstract Smartphone addiction is a recent concern that has resulted from the dramatic increase in worldwide smartphone use. The purpose of this cross-sectional study was to evaluate psychosocial factors affecting smartphone addiction in university students. The study was performed among students at the Ondokuz Mayis University Samsun School of Health (Samsun, Turkey) on October–December 2015. Four hundred ninety-four students possessing smartphones and agreeing to participate were included. A sociodemographic data form produced by the authors and consisting of 10 questions was administered together with a questionnaire involving the Smartphone Addiction Scale-Short Version (SAS-SV), the Flourishing Scale, the General Health Questionnaire, and the Multidimensional Scale of Perceived Social Support. The questionnaires were applied in a class environment at face-to-face interviews. SAS-SV scores of 6.47% of students were “significantly higher” than the participating group mean SAS-SV score. Multiple regression analysis revealed that depression, anxiety and insomnia, and familial social support statistically, significantly predicted smartphone addiction. Further studies of smartphone addiction in different age groups and with different educational levels are now needed.
Vertical individualism and injustice: The self‐restorative function of revenge

In the current paper, we examine the role of vertical individualism in determining revenge behavior following an injustice. Drawing on existing theory and research, we hypothesized that victims who are more vertically individualistic will be more likely than those who are less vertically individualistic to engage in revenge following the experience of injustice as a means of restoring self-esteem. The results from three studies—employing different methodologies and operationalizations of revenge—support our reasoning. Moreover, two of the studies provide support for the proposed self-esteem maintenance mechanism underlying the relation between vertical individualism and revenge. Although much research in psychology and organizational justice has demonstrated that the experience of injustice can threaten one's identity, our data are the first to demonstrate that responding to injustice can restore people's self-esteem to homeostasis. The present studies thus demonstrate that in some instances revenge may have an intrapsychic benefit for the victim, which helps to explain why some people engage in revenge despite possible negative interpersonal consequences. We discuss implications of our findings for social and organizational justice theory and for potentially mitigating revenge reactions to injustice. Copyright © 2012 John Wiley & Sons, Ltd.
Constraint, Word Frequency, and the Relationship between Lexical Processing Levels in Spoken Word Production

Abstract Producing a word to express a meaning requires the processes of lexical selection and phonological encoding. We argue that lexical selection is influenced by contextual constraint and phonological encoding by word frequency, and we use these variables to assess the processing relations between selection and encoding. In two experiments we examined latencies to name pictures presented within sentences. The sentences varied in degree of constraint, whereas the target picture-names varied in frequency. In both experiments, targets that followed constraining sentences showed substantially reduced frequency effects. When the targets followed incongruent sentence frames, the frequency effect returned. The results offer new support for the predictions of cascade theories of word production.
Evolutionary strategies for identification and validation of material model parameters for forming simulations

Identification and validation of material models for forming simulations to match experimental data is a key requirement of complex forming applications in the automotive industry. Besides the fact that these models need more and relatively expensive material data input, a problem is still the reliable fit of all necessary parameters. For the steel grade DX54, an interaction of strain rate and yield locus has been identified, finally leading to different material model calibrations. An even better accuracy of feasibility studies is promoted by using advanced yield locus models for forming simulations. With a new set of specially designed experiments in combination with evolutionary strategies, inverse material parameter identification is realized through minimization of a nonlinear error function. This approach defines a new and powerful method for selection and validation of the adequate material model for industrial simulation.
Political Participation of Teenagers in the Information Era

This study intends to examine the environments and the characteristics of political participation of teenage political participation. The 2008 Candlelight Protests of Korea is used as the case of this study. Traditionally, teenagers in Korea have been known to disengage from political affairs because they are usually worn by intense academic challenge and competition. In that sense, participation of teenagers at such a large scale shown in the 2008 Candlelight Protests of Korea can only be explained as a huge shift in political preference of teenagers and conventional social norms. In that sense, the case of 2008 Candlelight Protests of Korea has shown great implications for the political potential of new media, which is capable of revolutionizing the political socialization patterns of youth. Survey results demonstrated that the Internet had become an important tool from which the teenagers collected political information and channels which they used to organize and mobilize. Numbers also showed that the degree of the youth’s sociopolitical interests were higher than the adult’s. Another notable fact found was that female students showed more aggressive involvement than male students and this could be explained by the difference in the Internet usage pattern between male and female students. In using media, adolescent girls displayed more relationship and objective-oriented behaviors than the boys.
Molecular approaches for manipulating astrocytic signaling in vivo

Astrocytes are the predominant glial type in the central nervous system and play important roles in assisting neuronal function and network activity. Astrocytes exhibit complex signaling systems that are essential for their normal function and the homeostasis of the neural network. Altered signaling in astrocytes is closely associated with neurological and psychiatric diseases, suggesting tremendous therapeutic potential of these cells. To further understand astrocyte function in health and disease, it is important to study astrocytic signaling in vivo. In this review, we discuss molecular tools that enable the selective manipulation of astrocytic signaling, including the tools to selectively activate and inactivate astrocyte signaling in vivo. Lastly, we highlight a few tools in development that present strong potential for advancing our understanding of the role of astrocytes in physiology, behavior, and pathology.
Identification of elastic boundary conditions of light-weight device casing walls using experimental data

Device and machinery noise can be reduced by controlling vibration of casing walls - such approach, referred to as the active casing approach, has been successfully applied by the authors in previous publications. It was observed that for an effective active control it is crucial to mount sensors and actuators at appropriate locations on the vibrating structure. However, an optimization process of sensors and actuators arrangement requires a precise mathematical model of such structure. In this research a cuboid light-weight casing is considered. A mathematical model describing walls of such casing requires parameters to be defined that cannot be delivered by the producer nor measured directly. The aim of this paper is to develop and evaluate an identification procedure of model parameters basing on experimental data - distinguished natural frequencies and modeshapes. A memetic algorithm is used to find optimal set of model parameters. Automatic classification of simulated modeshapes is employed. Obtained results are validated experimentally for multiple casing walls.
“I Fear I’m a Checkbox”: College and University Victim Advocates’ Perspectives of Campus Rape Reforms

This study explores campus-based victim advocates’ perspectives on the process of implementing campus rape reforms mandated by federal policy. Interviews with 14 victim advocates and sexual assault prevention specialists were analyzed qualitatively using thematic analysis techniques. Participants described an increased focus on compliance as a means of managing the liability risks associated with inadequate policy implementation. These shifts toward compliance not only increased the motivation to accomplish reform but also limited those reforms by narrowing the focus. Participants described how narrow compliance resulted in decisions that may actually harm victims. Suggestions for improving policy and the implementation process are discussed.
Self-Reporting Tool On Pain in People with Intellectual Disabilities (STOP-ID!): a Usability Study

ABSTRACT The use of the Self-reporting Tool On Pain in people with Intellectual Disabilities (STOP-ID! ), an online application developed by the authors to aid in the self-reporting of pain, was evaluated in 40 adults with Down syndrome. Comprehension of the use of the tool (the ability to recognize representations for vocabulary and pain, and to navigate the tool interface), and the use of the tool to self-report pain experience, were investigated. The use of the online tool was investigated with both a laptop and a tablet computer in a crossover design. The results provide evidence that more participants recognized representations of pain location and pain affect than representations of pain intensity and pain quality. A small percentage of participants demonstrated the ability to recognize all of the representations of vocabulary items and to navigate the tool without assistance (18% laptop, 18% tablet). Half of the participants were able to report at least one pain component of a current or remembered pain experience without assistance (50% laptop, 53% tablet). Ways to improve the design of tools for reporting pain and to improve performance are suggested.