Miracle-dz/UniFAR-FTUs huggingface dataset:
Plastic restriction of HIV‐1 replication in human macrophages derived from M1/M2 polarized monocytes

M1/M2 cytokine‐dependent polarization of primary human MDMs has been shown to contain CCR5‐dependent (R5) HIV‐1 replication. In this study, a similar effect was achieved when monocytes were first polarized toward M1 or M2 and were infected 7 d after their differentiation into MDMs, regardless of whether the cytokines were removed 18 h after cell stimulation or were left in culture. Unlike polarized MDMs, no significant down‐regulation of CD4 from the cell surface was observed in MDMs derived from M1/M2‐polarized monocytes. A second stimulation of MDMs differentiated from M1/M2 monocytes with the opposite polarizing cytokines converted the virus replication profile according to the new stimuli. The expression of M1 and M2 markers (i.e., APOBEC3A and DC‐SIGN, respectively) was induced by MDM stimulation with the opposite cytokines, although it also persisted in cells according to their first stimulatory condition. Thus, stimulation of monocytes with M1‐ and M2‐inducing cytokines leads to a restriction of HIV‐1 replication when these cells are infected several days later as differentiated MDMs. These observations imply that activation of circulating monocytes significantly influences their capacity to either support or restrict HIV‐1 replication, once extravasated, and eventually to become infected as tissue macrophages.
Glutamatergic Regulation of the p70S6 Kinase in Primary Mouse Neurons*

Brief glutamatergic stimulation of neurons from fetal mice, cultured in vitro for 6 days, activates the mTOR-S6 kinase, ERK1/2 and Akt pathways, to an extent approaching that elicited by brain-derived neurotrophic factor. In contrast, sustained glutamatergic stimulation inhibits ERK, Akt, and S6K. Glutamatergic activation of S6K is calcium/calmodulin-dependent and is prevented by inhibitors of calcium/calmodulin-dependent protein kinase 2, phosphatidylinositol 3-OH-kinase and by rapamycin. 2-Amino-5-phosphonovaleric acid, an inhibitor of N′-methyl-D-aspartate receptors, abolishes glutamatergic activation of ERK1/2 but not the activation of mTOR-S6K; the latter is completely abolished by inhibitors of voltage-dependent calcium channels. Added singly, dopamine gives slight, and norepinephrine a more significant, activation of ERK and S6K; both catecholeamines, however, enhance glutamatergic activation of S6K but not ERK. After 12 days in culture, the response to direct glutamatergic activation is attenuated but can be uncovered by suppression of γ-aminobutyric acid interneurons with bicuculline in the presence of the weak K+ channel blocker 4-aminopyridine (4-AP). This selective synaptic activation of mTOR-S6K is also resistant to APV and inhibited by Ca2+ channel blockers and higher concentrations of glutamate. Elongation factor 2 (EF2) is phosphorylated and inhibited by the eEF2 kinase (CaM kinase III); the latter is inhibited by the S6K or Rsk. Bicuculline/4-AP or KCl-induced depolarization reduces, whereas higher concentrations of glutamate increases, EF2 phosphorylation. Thus the mTOR-S6K pathway in neurons, a critical component of the late phase of LTP, is activated by glutamatergic stimulation in a calcium/calmodulin-dependent fashion through a calcium pool controlled by postsynaptic voltage-dependent calcium channels, whereas sustained stimulation of extrasynaptic glutamate receptors is inhibitory.
Female representation in the decision-making structures of trade unions: The influences of sector, status and qualification

This article investigates women’s representation in the decision-making bodies of trade unions and the influences of sector, employee status and qualification. Since it can be assumed that external and internal factors have an effect on the structures and make-up of an organization, it follows that characteristics of both the members and the domain – such as sector, employee status and qualification – also influence the structures and make-up of trade unions and thus the degree of women’s participation in decision-making bodies. The study includes all Austrian and most of the German trade unions. Data are drawn from documentary material of the unions and expert interviews with union officials. The analysis shows that the services sector in combination with a blue-collar status produces a negative effect on women’s participation in unions’ decision-making structures, while higher qualification has a positive effect.
The Effect of Human Capital on Inwards FDI: Evidence from European transition economies

A country’s human capital has been neglected as a potential determinant of inwards foreign direct investment (FDI), both in theory and empirical research. When human capital has been included in models of the determinants of FDI, it appears simply as a control variable or one of the variables in a “kitchen sink” approach, usually without any theoretical rationale for its inclusion or critical discussion of the measures used. The mis-specification that may result from this is advanced as one of the potential explanations for the very diverse findings in previous literature and the failure of the meta-regression analysis (MRA) reported in this thesis to find an ‘authentic’ effect of human capital on inwards FDI. Accordingly, this research seeks to fill this gap, by identifying the mechanisms through which human capital is expected to attract FDI to European transition economies and drawing conclusions about the most appropriate measures of human capital given the characteristics of the former communist (education) system. The ‘productivity-enhancing’ skills and traits that (foreign) investors are likely to value in such economies are identified and the manner in which these skills are developed is analysed. In the light of this analysis the conventional human capital measures used in empirical analyses are critically assessed. These contributions are used to develop an empirical model for estimating the effect of human capital on inwards FDI at country-, sector- and industry-level in 12 European transition economies during the period 1995-2008. Consistent with the results of previous studies, as suggested by the MRA, no significant effect of traditional volume measures of human capital on FDI inflows/stocks is found. However, some evidence is presented in this thesis indicating that the quality dimension of human capital as measured by cognitive skills proxies may affect inwards FDI in the manufacturing sector. Accordingly, several potential explanations for the findings and some of their implications for future macro-level research focusing on the effects of human capital are explored.
Characteristics and use patterns of patients taking first-generation depot antipsychotics or oral antipsychotics for schizophrenia.

OBJECTIVE Investigators compared patient characteristics and antipsychotic use patterns between individuals with schizophrenia treated in usual care with first-generation depot antipsychotics and those treated with oral antipsychotics (first- or second-generation or both). METHODS Analyses used data from the U.S. Schizophrenia Care and Assessment Program, a large, prospective study of treatment for schizophrenia conducted July 1997 through September 2003. Participants were assessed at enrollment and every six months thereafter with patient self-report, validated psychiatric measures, and systematic extraction of medical records. Individuals treated with a first-generation depot antipsychotic at any time during the three-year study (N=569) were compared with those treated with only oral antipsychotics (N=1,617) on characteristics at enrollment and medication use pattern during the year after enrollment. RESULTS Compared with patients receiving only oral antipsychotics, participants treated with depot medications (haloperidol or fluphenazine decanoate) were more likely to be African American (p<.001); less likely to be a veteran (p=.005); had more psychiatric hospitalizations in the year before enrollment (p<.001); and were more likely to have been arrested (p<.001), to use alcohol and illicit substances (p<.001), and to show higher psychopathology, particularly psychotic symptoms and disorganized thinking (p<.01 for both). In the year after enrollment, participants treated with depot medications had a high mean medication possession ratio (91%), and most of the medication regimens (68%) were augmented with oral antipsychotics for prolonged durations (median of 144 days). CONCLUSIONS Patients with schizophrenia treated with first-generation depot antipsychotics differed from those treated with only oral antipsychotics. Findings suggest that first-generation depot antipsychotics might address some unmet needs of a unique subgroup of patients with schizophrenia.
Recycling in Multifamily Dwellings: Does Convenience Matter?

Factors that decrease the time cost of recycling have significant positive correlations with recycling rates in multifamily dwellings (MFDs). Waste-management experts have previously used anecdotes to infer a link between convenience and waste-diversion rates in MFD recycling programs. This article confirms and quantifies that link by applying probit and double-censored tobit analysis to survey data from 214 households in Urbana, Illinois. We find a strong connection between recycling rates and the perceived presence of adequate interior space for processing recyclables, and distance to recycling bins affects container-recycling intensity. The results have implications for cost-effective design of MFD recycling programs. (JEL DI, Q2) Copyright 2005, Oxford University Press.
The Changing Face of Private Equity: How Modern Private Equity Firms Manage Investment Portfolios

This article presents a comprehensive analysis of private equity management models and outlines two distinct models: one being a traditional financial investor with focus on financial engineering and selective changes in the governance model of portfolio companies, the other representing a modern form of private equity seeking value creation through active ownership. Active investors are able to significantly outperform more traditional financial investors by realizing the proceeds of intervention in strategic decision making, while avoiding the costs of “corporate infrastructure. ”
A conceptual framework of accounting policy choice under SSAP 20

Purpose - To provide a framework of accounting policy choice associated with the timing of adoption of the UK Statement of Standard Accounting Practice (SSAP) No. 20, "Foreign Currency Translation". The conceptual framework describes the accounting policy choices that firms face in a setting that is influenced by: their financial characteristics; the flexible foreign exchange rates; and the stock market response to accounting decisions. Design/methodology/approach - Following the positive accounting theory context, this paper puts into a framework the motives and choices of UK firms with regard to the adoption or deferment of the adoption of SSAP 20. The paper utilises the theoretical and empirical findings of previous studies to form and substantiate the conceptual framework. Given the UK foreign exchange setting, the framework identifies the initial stage: lack of regulation and flexibility in financial reporting; the intermediate stage: accounting policy choice; and the final stage: accounting choice and policy review. Findings - There are situations where accounting regulation contrasts with the needs and business objectives of firms and vice-versa. Thus, firms may delay the adoption up to the point where the increase in political costs can just be tolerated. Overall, the study infers that firms might have chosen to defer the adoption of SSAP 20 until they reach a certain corporate goal, or the adverse impact (if any) of the accounting change on firms' financial numbers is minimal. Thus, the determination of the timing of the adoption is a matter which is subject to the objectives of the managers in association with the market and economic conditions. The paper suggests that the flexibility in financial reporting, which may enhance the scope for income-smoothing, can be mitigated by the appropriate standardisation of accounting practice. Research limitations/implications - First, the study encompassed a period when firms and investors were less sophisticated users of financial information. Second, it is difficult to ascertain the decisions that firms would have taken, had the pound appreciated over the period of adoption and had the firms incurred translation losses rather than translation gains. Originality/value - This paper is useful to accounting standards setters, professional accountants, academics and investors. The study can give the accounting standard-setting bodies useful information when they prepare a change in the accounting regulation or set an appropriate date for the implementation of an accounting standard. The paper provides significant insight about the behaviour of firms and the associated impacts of financial markets and regulation on the decision-making process of firms. The framework aims to assist the market and other authorities to reduce information asymmetry and to reinforce the efficiency of the market. © Emerald Group Publishing Limited.
The Decline of Class Voting in Britain: Changes in the Basis of Electoral Choice, 1964-1983

This is a study of changes that have occurred in British party and electoral politics since 1964. It assesses the decline of Labour party support and attributes it to changes in social structure that have reduced the size of class groups which provided the bulk of the Labour vote and to the reduced appeal of Labour to these groups. A similar decline in Conservative support among traditional Tory social groups makes this a general phenomenon of declining class voting. The consequence of this decline has been to open the way to individual choice between parties based on issue preferences rather than class loyalty. It also results in the rising support for minor parties in response to new issue concerns. To account for these changes, the author employs evidence from surveys conducted after each of the seven general elections held between 1964 and 1983. The presentation has been so structured as to make it easy to follow the main line of argument.
Nonlinear Dynamics of Memristor Oscillators

A thorough investigation of the nonlinear dynamics of networks of memristor oscillators is a key step towards the design of systems based upon them, such as neuromorphic circuits and dense nonvolatile memories. A wide gamut of complex dynamic behaviors, including chaos, is observed even in a simple network of memristor oscillators, proposed here as a good candidate for the realization of oscillatory associative and dynamic memories. A detailed study of number and stability of all periodic and nonperiodic oscillations appearing in the network may not leave aside a preliminary deep understanding of the local and global behavior of the basic oscillator. Depending on two bifurcation parameters, controlling memristor nonlinearity, the oscillator exhibits different dynamic behaviors, analyzed here through application of state-of-the-art techniques from the theory of nonlinear dynamics to the oscillator model.
A tale of two representations: the misinformation effect and children's developing theory of mind.

The present research investigates representational ability as a cognitive factor underlying the suggestibility of children's eyewitness memory. The misinformation effect is used as an index of children's suggestibility, and performance on the false belief task is used as an assessment of children's representational abilities (N = 117). Analyses that considered the effect of representational ability and general memory ability on children's susceptibility to misleading information showed that differences in representational ability and general memory ability predicted participants' susceptibility to misleading information. These results demonstrate that the eyewitness memory of children who lack either multirepresentational abilities, sufficient general memory abilities, or both (i.e., most 3- and 4-year-olds) is less accurate than the eyewitness memory of children with both multirepresentational abilities and sufficient memory abilities (i.e., most 6-year-olds and adults). Thus, it appears that the earliest age at which children's eyewitness memory can be considered to be similar to that of adults is 6 years of age, when children's mental representational abilities are similar to those of adults. These results suggest that one factor underlying children's vulnerability to misleading information is the number of representations of an event that they can simultaneously hold and compare.
Employment status and subjective well-being: the role of the social norm to work

This article examines to what extent a social norm to work moderates the relationship between employment status and subjective well-being. It was expected that the detrimental impact of non-employment on subjective well-being would be larger in countries with a stronger social norm. Using a direct measure of the social norm to work and employing data from 45 European countries, this study assessed subjective well-being levels of five employment status groups for men and women separately. Results showed that subjective well-being of unemployed men and women is unaffected by the social norm to work. However, non-working disabled men are worse off in countries with a stronger norm. Living in such a country also decreases the well-being gap between employed and retired men, whereas retired women are worse off in these countries. This effect for retirees disappears when a country’s GDP is taken into account, suggesting that norms matter less than affluence.
Mind the Gap? Political Advertisements and Congressional Election Results

Do political television advertisements influence congressional election results? We test a hypothesis that candidates increase their vote share by increasing their advertisement airings relative to their opponent's airings (i.e., “mind the gap”). Using aggregate advertising data over three election cycles, we employ a two-stage least squares estimation with a rank-order instrumental variable, finding that the advertisement gap explains shifts in vote share after controlling for variables standard to congressional election modeling and advertisement volume. This methodological approach mitigates the endogenous relationship between advertisement airings and election results.
R&D Reactions To High-Technology Import Competition

For a seventeen-year panel covering 308 U.S. manufacturers, the authors analyze companies' R&D spending reactions to changes in high-technology imports. On average, R&D/sales ratios were reduced in the short run as imports rose. Reactions tended to be more aggressive the more concentrated the markets were in which the firms operated, when company R&D operations were multinational, and with greater company size and diversification. Reactions were less aggressive when special trade barriers had been erected. Reactions became more aggressive over the longer run. Copyright 1992 by MIT Press.
Working Paper 21-08 - Impact of the EU Energy and Climate Package on the Belgian energy system and economy - Study commissioned by the Belgian federal and three regional authorities

In order to prepare for the negotiations on the EU Energy and Climate Package, the Federal Planning Bureau was asked by the Belgian federal and regional authorities to conduct a study on the impact of the January 2008 European Commission's proposal. In the course of this study, various scenarios were run. Next to a baseline, two main alternative scenarios were scrutinised: the 20/20 and 30/20 target scenarios, standing for an EU reduction of respectively 20% and 30% of GHG emissions in the year 2020 compared to the level of 1990 and a 20% mandatory EU share of RES in Gross Final Energy Demand in 2020. The report then includes an analysis of the impact of both scenarios on the Belgian energy system and economy as well as on GHG emissions.
Effect of the organic loading rate on biogas composition in continuous fermentative hydrogen production

Some systems did not select for hydrogen-producing microorganisms and an unexpected growth of hydrogenotrophic methanogens was observed, although the reactors were operated under well-defined operating conditions that could result in biohydrogen production. The aim of this study was to evaluate the effect of the organic loading rate (OLR) on the hydrogen and methane composition of the biogas produced in dark fermentative processes. The study was carried out using an upflow anaerobic sludge blanket (UASB) reactor in order to evaluate the OLR effect in systems with sludge retention. During continuous operation, the UASB reactor showed the slow development of methanogenic activity, related to the applied OLR. The results demonstrate that operating an UASB reactor at pH 5.5 is not enough to prevent the acclimation of methanogens to the acidic pH and therefore long-term biohydrogen production cannot be achieved. Moreover, this study demonstrates that OLR also has an effect on the biogas composition, where the higher the OLR the greater the biogas H2 content.
[Risk factors for low birth weight and intrauterine growth retardation in Santiago, Chile].

An epidemiologic case-control study to ascertain the determinants of low birthweight was carried out in Santiago, Chile, from January to December 1989. The cases were defined as livebirths < 2500 g. The controls were livebirths > or = 2500 g of birthweight. All cases and a random sample (1:1) of controls were selected among 8,254 singleton births occurring at the El Salvador Hospital in the Eastern area of Santiago. These deliveries represented 50% of institutional deliveries in the area. Home deliveries (2%) and private hospital deliveries were not included in the study. Information was obtained from hospital medical records by six trained medical students. Some information could not be obtained from the hospital medical records. Thus the second step in data collection was the tracking of all the selected subjects to their referring neighborhood health centers. For the analysis, the data were divided into 3 case (outcome) categories: 453 subjects were the total case group. From these, 153 were the IUGR case group and 300 were the LBW preterm case group. The general control group consisted of 605 normal birthweight infants. 565 were the IUGR control group and 40 were the preterm control group. A total of 25 risk factors showed a significant crude odds ratio for at least one of the groups. In the multivariate logistic regression analysis eight variables: No. of pregnancies, previous adverse outcomes, previous LBW, pregnancy maternal weight, No. of visits, month of first prenatal care visit, maternal smoking and intrahepatic cholestasis of pregnancy, were significantly associated with LBW after adjustment by confounding. Eight risk factors: IUGR in previous pregnancies, Previous adverse outcome, Maternal smoking, intrahepatic cholestasis, maternal pregnancy weight, maternal height, month first prenatal visit, No. of visit, were significant to IUGR. Only two variables: pregnancy weight, divorced mother, were significantly associated with low birth weight in the preterm group. The most relevant risk factors were included in stepwise logistic regression models carried out for the outcome LBW for the general group, term group and preterm group, in order to adjust by confounding. Adjusted odds ratios were then obtained. Prenatal care related factors and maternal adverse obstetric factors were at higher significance for LBW in the general and IUGR groups. Only nutritional factors were related to LBW in preterm group. Women who delivered a LBW or IUGR infant were more likely to have fewer pregnancies, a history of previous LBW, lower prepregnancy weight and lower gestational weight gain. ICP was associated with an elevated risk of LBW that was independent of gestational age.