Miracle-dz/UniFAR-FTUs huggingface dataset:
Results from the 1995 Stratospheric Ozone Profile Intercomparison at Mauna Loa

In August 1995, multiple instruments that measure the stratospheric ozone vertical distribution were intercompared at the Mauna Loa Observatory, Hawaii, under the auspices of the Network for the Detection of Stratospheric Change. The instruments included two UV lidar systems, one from the Jet Propulsion Laboratory and the other from Goddard Space Flight Center, electrochemical concentration cell balloon sondes, a ground-based microwave instrument, Dobson-based Umkehr measurements, and a new ground-based Fourier transform infrared instrument. The Microwave Limb Sounder instrument on the Upper Atmosphere Research Satellite provided correlative profiles of ozone, and there was one close overpass of the Stratospheric Aerosol and Gas Experiment II (SAGE II) instrument. The results show that much better consistency among instruments is being achieved than even a few years ago, usually to within the instrument uncertainties. The different measurement techniques in this comparison agree to within ±10% at almost all altitudes, and in the 20–45 km region most agreed within ±5%. The results show that the current generation of lidars is capable of accurate measurement of the ozone profile to a maximum altitude of 50 km. SAGE II agreed well with both lidar and balloon sonde down to at least 17 km. The ground-based microwave measurement agreed with other measurements from 22 km to above 50 km. One minor source of disagreement continues to be the pressure-altitude conversion needed to compare a measurement of ozone density versus altitude with a measurement of ozone mixing ratio versus pressure.
BslA(YuaB) forms a hydrophobic layer on the surface of Bacillus subtilis biofilms

Biofilms are surface‐associated bacterial aggregates, in which bacteria are enveloped by polymeric substances known as the biofilm matrix. Bacillus subtilis biofilms display persistent resistance to liquid wetting and gas penetration, which probably explains the broad‐spectrum resistance of the bacteria in these biofilms to antimicrobial agents. In this study, BslA (formerly YuaB) was identified as a major contributor to the surface repellency of B. subtilis biofilms. Disruption of bslA resulted in the loss of surface repellency and altered the biofilm surface microstructure. BslA localized to the biofilm matrix in an exopolysaccharide‐dependent manner. Purified BslA exhibited amphiphilic properties and formed polymers in response to increases in the area of the air–water interface in vitro. Genetic and biochemical analyses showed that the self‐polymerization activity of BslA was essential for its ability to localize to the biofilm matrix. Confocal laser scanning microscopy showed that BslA formed a layer on the biofilm surface. Taken together, we propose that BslA, standing for biofilm‐surface layer protein, is responsible for the hydrophobic layer on the surface of biofilms.
Identity, Expertise and HIV Risk in a Case Study of Reflexivity and Medical Technologies

Using qualitative interviews with gay men with HIV and with reference to identity, expertise and HIV medical technologies, this article contributes to debate concerning the concept of risk reflexivity. Since the mid 1990s, people with HIV in the affluent, global North have had access to HIV treatment that substantially improves health. Recent research has expressed fears that, by satisfying hopes for effective treatment among affected citizens, HIV prevention will be undermined. This paradoxical idea has sharpened focus on how users apply knowledge regarding the effects of treatment on the risk of HIV transmission through sexual practice. This article argues that the concept of risk reflexivity has value because it draws attention to the limitations of extant assumptions about the users of HIV medical technologies. But this concept requires development in terms of the positioning of the person with HIV in risk reflexivity and the related mobilization of blame.
Creation of a double chimera after the transplantation of umbilical-cord blood from two partially matched unrelated donors.

To the Editor: Despite promising outcomes in the transplantation into pediatric recipients of umbilical-cord blood from unrelated donors, the low cell dose adversely affects both the rate of hematopoietic recovery and the probability of survival.1–3 The cell dose is a major limitation of the procedure, particularly in adults. An alternative to the ex vivo expansion of cells, which has yet to be shown to be efficacious, is the transplantation of 2 closely HLA-matched units of umbilical-cord blood. We transplanted 2 units of umbilical-cord blood from male infant donors into a 53-year-old, 84-kg woman with accelerated-phase chronic myelogenous leukemia and .
Disabled Readers’ Performance on Tasks of Phonological Processing, Rapid Naming, and Letter Knowledge before and after Kindergarten

The importance of early identification of children at risk for reading failure is clearly established in the literature. The purpose of this longitudinal retrospective study was to further define the relationship between the development of prereading skills and later reading outcome in two groups of children; a group of reading–disabled children and a group of their normally reading peers. Children's alphabetic knowledge, phonological awareness, and rapid naming skills were explored at the beginning of kindergarten and again prior to first grade as a function of later reading outcomes. Results indicate that differences found between the groups in all measures at prekindergarten age diminish by prefirst grade with the exception of phonological awareness abilities. Findings have direct implications for screening children at risk for reading difficulties and the time–sensitive nature of these tasks during the preliteracy period.
THE RELIABILITY OF SOME VOSTS ITEMS WHEN USED WITH PRESERVICE SECONDARY SCIENCE TEACHERS IN ENGLAND

A selection of Views on Science–Technology–Society (VOSTS) items was made and administered to a group of 29 postgraduate trainee science teachers. Two sections of VOSTS were addressed: VOSTS 1 (Defining Science and Technology) and VOSTS 9 (Epistemology). Reliability was determined by a cross-tabulation procedure following a retest. All 27 items selected were generally found to be reliable, although when put to a severe treatment, 24 of 27 items were found to be reliable. A cluster analysis of the responses was also carried out: Two main clusters were obtained for VOSTS 1 and three for VOSTS 9. The findings are discussed, compared with those from the Canadian study, and reviewed in the context of professional development of science teachers. © 1998 John Wiley & Sons, Inc. J Res Sci Teach 35: 53-71, 1998.
‘Well weather is not a girl thing is it?’ Contemporary amateur meteorology, gender relations and the shaping of domestic masculinity

Although there is a growing scholarship on the history of amateur meteorology, contemporary amateur meteorology has tended to remain a largely invisible social phenomenon. Moreover, questions of female involvement and gender relations therein have tended to be overlooked. This paper seeks to address this gap by drawing on interviews with members of one of the most important amateur meteorological networks in the UK—the Climatological Observers Link. The research identifies a predominantly male bias within amateur meteorology in the UK, offers insight into why and how this bias has emerged and explores the implications of this bias for gender politics in the home. It also considers the way in which, as a pursuit that is very much situated within the domestic sphere, amateur meteorology complicates traditional framings of the home as a female realm and contributes to a domestic masculinity.
The short stem GHEs in total hip replacement – experience after 380 implantations

Introduction: Standard straight stems have been recognized as a gold standard implant in the field of hip replacement surgery. However, lately uncemented bone-preserving short stems started to gain more and more popularity. This was reflected in the increasing variety of available models. Up till now, short and mid-term results are available. Patients and methods: In 2002, the cementless short stemmed GHEs was introduced. 380 patients were included in our study between 2002 and 2008. Only GHEs short stems were implanted. The clinical and radiological evaluations were performed in the Orthopaedic Department, Leipzig University Hospitals, on the average of 24 months (3 to 60 months) postoperatively. Results: 365 primary implantations and 15 revision implantations were carried out. Average age 60 years. Favourable clinical and radiological outcome was seen in 361/380 patients (95%). Postoperative complications were seen in 19/380 patients (5%): 8 fissures/fractures (2.1%), 5 infections (1.3%), 4 aseptic loosenings (1.1%), 2 dislocations (0.5%). Conclusions: Short stem implants, including our own experience with GHEs model, are satisfying and promising. They represent a valuable supplementation of the treatment modalities in hip replacement surgery. However, long term results are still awaited.
Effects of Self-Esteem on Vulnerability-Denying Defensive Distortions: Further Evidence of an Anxiety-Buffering Function of Self-Esteem

Abstract Two studies were conducted to assess the proposition that self-esteem serves an anxiety-buffering function. In Study 1, it was hypothesized that raising self-esteem would reduce the need to deny vulnerability to early death. In support of this hypothesis, positive personality feedback eliminated subjects′ tendency to bias emotionality reports to deny vulnerability to a short life expectancy-except when mortality had been made salient to the subjects. Study 2 conceptually replicated this effect by demonstrating that whereas subjects low in trait self-esteem biased emotionality reports to deny vulnerability to a short life expectancy, subjects high in trait self-esteem did not exhibit such a bias. Thus, converging evidence that self-esteem reduces vulnerability-denying defensive distortions was obtained.
A project for Romania? The role of the civil society’s counter-accounts in facilitating democratic change in society

Purpose - – The purpose of this paper is to look more closely, in the context of a given case study, at the role of civil society’s counter-accounts in facilitating democratic change in society, as an essential goal of an emancipatory and radical social accounting project. Design/methodology/approach - – A case study of a Canadian company’s plans to open a gold mine in western Romania is here analysed. Civil society’s opposition to the mining project gave rise to an unprecedented social movement contesting the project’s utility for Romanian society. The role played by counter-accounts produced by civil society groups is investigated. Findings - – Counter-accounts produced by civil society played multiple roles in the case study analysed. First, counter-accounts indicated the failure of corporate reports to present the gold mining project in a balanced manner. Second, counter-accounts were successful in problematizing the corporate approach to addressing the social, cultural and environmental impacts of the project, while also nurturing societal debate on these issues. Third, counter-accounts exposed the ideological inclinations of state institutions to favour economic interests over the social, cultural and environmental ones. As a result of these contributions, even if the counter-accounts were subjective, this study claims that they form a good basis for the development of emancipatory accounting. Research limitations/implications - – Limitations associated with an interpretative approach and case study research apply. Originality/value - – The paper illustrates the potential of civil society’s counter accounts to enable societal debates, as means towards democratic, transformative change.
Evidence for Human Leukocyte Antigen-Related Susceptibility in Idiopathic Childhood Ischemic Stroke

Stroke in children is a relatively uncommon condition and frequently associated with other diseases like cardiopathies, sickle cell disease and chronic smoking. In contrast to stroke in adults, it is rarely caused by atherosclerosis, hypertension or diabetes mellitus. Childhood stroke of unknown causes is called idiopathic stroke. The etiology of idiopathic stroke is unknown. However, several so-called idiopathic diseases develop on the basis of a genetic predisposition. As an approach to investigate this possibility in idiopathic childhood ischemic stroke, we studied the relationship between clinical and immunogenetic features in this disease. We demonstrate that the gene frequencies and relative risk of HLA-B51 were markedly increased in our patients compared with controls (p < 0.001). Thirteen of seventeen HLA-B51-positive patients had had a preceding respiratory infection, which was a higher proportion than in the control group (p < 0.05). In the patient group, the alleles HLA-DRB1*0802, -DRAI*0401 and -DQBI*0402 were also significantly increased, defining the haplotype DRB1*0802-DRA1*0401-DQB1*0402 as a high-risk haplotype for idiopathic childhood ischemic stroke. Transient viral or bacterial infections, which involve vasculitis and vascular occlusion in the brain, can trigger idiopathic childhood ischemic stroke on the basis of an genetic predisposition.
Overview of the Infectious Diseases (ID) task of BioNLP Shared Task 2011

This paper presents the preparation, resources, results and analysis of the Infectious Diseases (ID) information extraction task, a main task of the BioNLP Shared Task 2011. The ID task represents an application and extension of the BioNLP'09 shared task event extraction approach to full papers on infectious diseases. Seven teams submitted final results to the task, with the highest-performing system achieving 56% F-score in the full task, comparable to state-of-the-art performance in the established BioNLP'09 task. The results indicate that event extraction methods generalize well to new domains and full-text publications and are applicable to the extraction of events relevant to the molecular mechanisms of infectious diseases.
Autophagy and the (Pro)renin Receptor

The (pro)renin receptor (PRR) is a newly reported member of the renin-angiotensin system (RAS); a hormonal cascade responsible for regulating blood pressure. Originally, identification of PRR was heralded as the next drug target of the RAS, of which such therapies would have increased benefits against target-organ damage and hypertension. However, in the years since its discovery, several conditional knockout mouse models of PRR have demonstrated an essential role for this receptor unrelated to the RAS and blood pressure. Specific deletion of PRR in podocytes or cardiomyocytes resulted in the rapid onset of organ failure and subsequently animal mortality after only a matter of weeks. In both cell types, loss of PRR resulted in the intracellular accumulation of autophagosomes and misfolded proteins, indicating a disturbance in autophagy. In light of the fact that the majority of PRR is located intracellularly, this molecular function appears to be more relevant than its ability to bind to high, non-physiological concentrations of (pro)renin. This review will focus on the role of PRR in autophagy and its importance in maintaining cellular homeostasis. Understanding the link between PRR, autophagy and how its loss results in cell death will be essential for deciphering its role in physiology and pathology.
The association between the failure of dental implants and cigarette smoking.

This paper reviews the outcome of 2,194 Brånemark implants placed in 540 patients by one of the authors over a 6-year period. The overall failure rate of 5.92% is consistent with other studies; however, when patients were subdivided into smokers and nonsmokers, it was found that a significantly greater percentage of failures occurred in smokers (11.28%) than in nonsmokers (4.76%) (P < .001). These differences were significant for all areas except the posterior mandible. While failure rates decreased with increasing implant length, failure rates for each implant length were consistently higher in smokers than in nonsmokers. The possible mechanisms of failure in smokers are discussed, and a protocol for cessation of smoking around the time of surgery is proposed.
Deception detection based on repeated interrogations

Purpose. Suspects are often subjected to multiple interrogations. Research on deception has neglected this fact. To remedy this shortcoming this study was conducted focusing on how repeated interrogations affect deception detection performance. In addition, the previous finding that interrogators interacting face to face tend to be more credulous towards suspects than observers watching the same suspects on video was tested. Method. After seeing a staged event, 12 lying and 12 truth-telling witnesses were interrogated three times over a period of 11 days. After the final interrogation the veracity of each witness was assessed by his or her interrogator and by six observers who had seen the interrogations on video. In all, 144 observers were used and all participants were undergraduate students. Results. The main findings were that (1) both interrogators and observers were poor at discerning truth-tellers and liars; (2) observers who made veracity judgments after seeing one interrogation performed in line with observers who had seen three interrogations; (3) observers who assessed veracity after seeing one interrogation and then, again, after watching the additional two, significantly increased their performance; and (4) the interrogators showed a very pronounced truth bias. Conclusions. The results suggest that interrogators should be careful not to hold a too lenient attitude towards suspects. Importantly, the study also shows that the number of veracity assessments made is more related to deception detection performance than is the number of interrogations a judge presides over. The finding that lie-catchers' performance is affected by both how sequential information is presented and integrated has important psycho-legal implications.
α-granule biogenesis: from disease to discovery

Abstract Platelets are critical to hemostasis and thrombosis. Upon detecting injury, platelets show a range of responses including the release of protein cargo from α-granules. This cargo is synthesized by platelet precursor megakaryocytes or endocytosed by megakaryocytes and/or platelets. Insights into α-granule biogenesis have come from studies of hereditary conditions where these granules are immature, deficient or absent. Studies of Arthrogryposis, Renal dysfunction, and Cholestasis (ARC) syndrome identified the first proteins essential to α-granule biogenesis: VPS33B and VPS16B. VPS33B and VPS16B form a complex, and in the absence of either, platelets lack α-granules and the granule-specific membrane protein P-selectin. Gray Platelet Syndrome (GPS) platelets also lack conventionally recognizable α-granules, although P-selectin containing structures are present. GPS arises from mutations affecting NBEAL2. The GPS phenotype is more benign than ARC syndrome, but it can cause life-threatening bleeding, progressive thrombocytopenia, and myelofibrosis. We review the essential roles of VPS33B, VPS16B, and NBEAL2 in α-granule development. We also examine the existing data on their mechanisms of action, where many details remain poorly understood. VPS33B and VPS16B are ubiquitously expressed and ARC syndrome is a multisystem disorder that causes lethality early in life. Thus, VPS33B and VPS16B are clearly involved in other processes besides α-granule biogenesis. Studies of their involvement in vesicular trafficking and protein interactions are reviewed to gain insights into their roles in α-granule formation. NBEAL2 mutations primarily affect megakaryocytes and platelets, and while little is known about NBEAL2 function some insights can be gained from studies of related proteins, such as LYST.
Performance modelling of distributed e-business applications using Queuing Petri Nets

In this paper we show how Queuing Petri Net (QPN) models can be exploited for performance analysis of distributed e-business systems. We study a real-world application, and demonstrate the benefits, in terms of modelling power and expressiveness, that QPN models provide over conventional modelling paradigms such as Queuing Networks and Petri Nets. As shown, QPNs facilitate the integration of both hardware and software aspects of system behavior in the same model. In addition to hardware contention and scheduling strategies, using QPNs one can easily model simultaneous resource possession, synchronization, blocking and contention for software resources. By validating the models presented through measurements, we show that they are not just powerful as a specification mechanism, but are also very powerful as a performance analysis and prediction tool. However, currently available tools and techniques for QPN analysis are limited. Improved solution methods, which enable larger models to be analyzed, need to be developed. By demonstrating the power of QPNs as a modelling paradigm in realistic scenarios, we hope to motivate further research in this area.
Packet Classification with Hierarchical Cross-Producting

Packet classification has become one of the most important application techniques in network security since the last decade. The technique involves a traffic descriptor or user-defined criteria to categorize packets to a specific forwarding class which will be accessible for future security handling. To achieve fast packet classification, we propose a new scheme, Hierarchical Cross-Producting. This approach simplifies the classification procedure and decreases the distinct combinations of fields by hierarchically decomposing the multi-dimensional space based on the concept of telescopic search. Analogous to the use of telescopes with different powers**, a multiple-step process is used to search for targets. In our scheme, the multi-dimensional space is endowed with a hierarchical property which self-divides into several smaller subspaces, whereas the procedure of packet classification is translated into recursive searching for matching subspaces. The required storage of our scheme could be significantly reduced since the distinct field specifications of subspaces is manageable. The performance are evaluated based on both real and synthetic filter databases. The experimental results demonstrate the effectiveness and scalability of the proposed scheme.