Miracle-dz/UniFAR-FTUs huggingface dataset:
Cortical network architecture for context processing in primate brain

Context is information linked to a situation that can guide behavior. In the brain, context is encoded by sensory processing and can later be retrieved from memory. How context is communicated within the cortical network in sensory and mnemonic forms is unknown due to the lack of methods for high-resolution, brain-wide neuronal recording and analysis. Here, we report the comprehensive architecture of a cortical network for context processing. Using hemisphere-wide, high-density electrocorticography, we measured large-scale neuronal activity from monkeys observing videos of agents interacting in situations with different contexts. We extracted five context-related network structures including a bottom-up network during encoding and, seconds later, cue-dependent retrieval of the same network with the opposite top-down connectivity. These findings show that context is represented in the cortical network as distributed communication structures with dynamic information flows. This study provides a general methodology for recording and analyzing cortical network neuronal communication during cognition. DOI: http://dx.doi. org/10.7554/eLife.06121. 001
HEMOLYTIC ANTIBODIES FOR SHEEP AND OX ERYTHROCYTES IN INFECTIOUS MONONUCLEOSIS.

Paul and Bunnell (1932) observed very high concentrations of agglutinins and hemolysins for sheep cells in the sera of patients during the acute stages of infectious mononucleosis, and this observation was found by these investigators to be of much value in the diagnosis of the disease. This finding has been confirmed and extended by Rosenthal and Wenkebach (1933), Boveri (1933), Bunnell (1933) and Bernstein (1934). In addition to the practical application in diagnosis, theoretical interest centers about the fact that antibodies for sheep cells are produced or enhanced in a disease of unknown etiology. Paul and Bunnell offered two explanations for their findings: (1) that the unknown agent responsible for infectious mononucleosis contains the heterophile or Forssman antigen; (2) that they were dealing with an example of isoagglutinin production elicited by abnormal cells, which are present either in the blood, or elsewhere, during active stages of the disease. In studies of infectious mononucleosis by different investigators, a probable bacterial origin has often been suggested, with special mention of the streptococcus group, diphtheroid bacilli, and Vincent's organisms, all of which have been found in nose, mouth or throat lesions during the disease. Nyfeldt (1929) has reported the isolation of a small V-shaped or curved gram positive organism from the blood, which he called Bacterium monocytogenes hominis, and with which he produced the cellular blood picture of infectious mononucleosis in rabbits. Agglutination of this organism in 1 to 250 dilution by the serum of the patient was observed, but only five days after the temperature had become normal. Gorham, Smith and Hunt (1929) claimed to have produced the typical blood picture of the disease in guinea pigs by inoculation of membrane from the pharynx of
A Regional News Corpora for Contextualized Entity Discovery and Linking

This paper presents a German corpus for Named Entity Linking (NEL) and Knowledge Base Population (KBP) tasks. We describe the annotation guideline, the annotation process, NIL clustering techniques and conversion to popular NEL formats such as NIF and TAC that have been used to construct this corpus based on news transcripts from the German regional broadcaster RBB (Rundfunk Berlin Brandenburg). Since creating such language resources requires significant effort, the paper also discusses how to derive additional evaluation resources for tasks like named entity contextualization or ontology enrichment by exploiting the links between named entities from the annotated corpus. The paper concludes with an evaluation that shows how several well-known NEL tools perform on the corpus, a discussion of the evaluation results, and with suggestions on how to keep evaluation corpora and datasets up to date.
Network resilience against intelligent attacks constrained by the degree-dependent node removal cost

We study the resilience of complex networks against attacks in which nodes are targeted intelligently, but where disabling a node has a cost to the attacker which depends on its degree. Attackers have to meet these costs with limited resources, which constrains their actions. A network's integrity is quantified in terms of the efficacy of the process that it supports. We calculate how the optimal attack strategy and the most attack-resistant network degree statistics depend on the node removal cost function and the attack resources. The resilience of networks against intelligent attacks is found to depend strongly on the node removal cost function faced by the attacker. In particular, if node removal costs increase sufficiently fast with the node degree, power law networks are found to be more resilient than Poissonian ones, even against optimized intelligent attacks. For cost functions increasing quadratically in the node degrees, intelligent attackers cannot damage the network more than random damages would.
Möbius: Trustless Tumbling for Transaction Privacy

Abstract Cryptocurrencies allow users to securely transfer money without relying on a trusted intermediary, and the transparency of their underlying ledgers also enables public verifiability. This openness, however, comes at a cost to privacy, as even though the pseudonyms users go by are not linked to their real-world identities, all movement of money among these pseudonyms is traceable. In this paper, we present Möbius, an Ethereum-based tumbler or mixing service. Möbius achieves strong notions of anonymity, as even malicious senders cannot identify which pseudonyms belong to the recipients to whom they sent money, and is able to resist denial-of-service attacks. It also achieves a much lower off-chain communication complexity than all existing tumblers, with senders and recipients needing to send only two initial messages in order to engage in an arbitrary number of transactions.
Adhesion of glass/epoxy composites influenced by thermal and cryogenic environments

Little information regarding the effects of prior thermal and cryogenic conditionings on hydrothermal and mechanical behavior, for varied volume fractions of constituent phases in polymer matrix fiber composites, has been published to date. The present experimental investigation uses flexural test to assess the effects of thermal and cryogenic treatments, and concurrently followed hydrothermal aging on quality of adhesion of multilayered laminates for 55, 60, and 65 wt % of E-glass fiber-reinforced epoxy composites. The specimens were conditioned at 80°C and −80°C temperatures for different time durations, and thereafter they were immediately immersed in boiling water for an hour. Water absorption rates were evaluated for those conditioned specimens in such environment. Absorption study in hydrothermal aging showed a remarkable variation for the two cases of prior conditionings. The shear strength values were compared with the test value of as-cured samples. Degradation of mechanical property was found to be less prevalent during hydrothermal aging, with a prior conditioning at 80°C temperature compared to −80°C treated glass/epoxy composites. Improved shear strength for almost all conditions of thermal conditioning in the initial stages has highlighted better adhesion influenced by postcuring phenomena during thermal or cryogenic conditioning. It was also observed from water absorption data that high temperature conditioning contributed more strengthening effect and better adhesion at the interfaces. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 1943–1949, 2006
DISAPPEARANCE OF COMET C/2010 X1 (ELENIN): GONE WITH A WHIMPER, NOT A BANG

We examine the rise and sudden demise of comet C/2010 X1 (Elenin) on its approach to perihelion. Discovered inbound at 4.2 AU, this long-period comet was predicted to become very bright when near perihelion, at 0.48 AU on 2011 September 10. Observations starting 2011 February (heliocentric distance ∼3.5 AU) indeed show the comet to brighten by about 11 mag, with most of the increase occurring inside 1 AU from the Sun. The peak brightness reached mR = 6 on UT 2011 August 12.95 ± 0.50, when at ∼0.83 AU from the Sun. Thereafter, the comet faded even as the heliocentric distance continued to decrease. We find that most of the surge in brightness in mid-August resulted from dust-particle forward scattering, not from a sudden increase in the activity. A much smaller (∼3 mag) brightening began on UT 2011 August 18 ± 1 (heliocentric distance 0.74 AU), reached a maximum on UT 2011 August 30 ± 1 (at 0.56 AU), and reflects the true breakup of the nucleus. This second peak was matched by a change in the morphology from centrally condensed to diffuse. The estimated cross section of the nucleus when at 1 AU inbound was ∼1 km2, corresponding to an equal-area circle of radius 0.6 km. Observations were taken after the second peak using the Canada–France–Hawaii 3.6 m telescope to search for surviving fragments of the nucleus. None were found to a limiting red magnitude r′ = 24.4, corresponding to radii ≲40 m (red geometric albedo = 0.04 assumed). The brightening, the progressive elongation of the debris cloud, and the absence of a central condensation in data taken after UT 2011 August 30 are consistent with disintegration of the nucleus into a power law size distribution of fragments with index q = 3.3 ± 0.2 combined with the action of radiation pressure. In such a distribution, the largest particles contain most of the mass while the smallest particles dominate the scattering cross section and apparent brightness. We speculate about physical processes that might cause nucleus disruption in a comet when still 0.7 AU from the Sun. Tidal stresses and devolatilization of the nucleus by sublimation are both negligible at this distance. However, the torque caused by mass loss, even at the very low rates measured in comet Elenin, is potentially large enough to be responsible by driving the nucleus to rotational instability.
Hepatitis E Virus Genotype 3 Diversity: Phylogenetic Analysis and Presence of Subtype 3b in Wild Boar in Europe

An increasing number of indigenous cases of hepatitis E caused by genotype 3 viruses (HEV-3) have been diagnosed all around the word, particularly in industrialized countries. Hepatitis E is a zoonotic disease and accumulating evidence indicates that domestic pigs and wild boars are the main reservoirs of HEV-3. A detailed analysis of HEV-3 subtypes could help to determine the interplay of human activity, the role of animals as reservoirs and cross species transmission. Although complete genome sequences are most appropriate for HEV subtype determination, in most cases only partial genomic sequences are available. We therefore carried out a subtype classification analysis, which uses regions from all three open reading frames of the genome. Using this approach, more than 1000 published HEV-3 isolates were subtyped. Newly recovered HEV partial sequences from hunted German wild boars were also included in this study. These sequences were assigned to genotype 3 and clustered within subtype 3a, 3i and, unexpectedly, one of them within the subtype 3b, a first non-human report of this subtype in Europe.
A case control population-based study investigating smoking as a risk factor for gastroschisis in Utah, 1997-2005.

BACKGROUND Smoking in pregnancy increases the risk for many different adverse pregnancy outcomes, including birth defects. Gastroschisis, a birth defect most commonly associated with young maternal age has been associated with smoking, but findings are inconsistent. We assessed whether smoking increases the risk for gastroschisis using population-based data from Utah. METHODS Gastroschisis cases (n = 189) were identified from the Utah Birth Defect Network and all live births without birth defects (n = 423,499) occurring in Utah from January 1, 1997 through December 31, 2005 served as controls. Exposure data were derived from birth certificates and fetal death certificates and, for terminated pregnancies, the Utah Birth Defect Network. RESULTS Women who smoked during the first trimester of pregnancy had an increased risk of gastroschisis (OR 1.6; 95% CI: 1.1, 2.3) after adjusting for maternal age and preconception BMI. Discordance between birth certificate data and data from structured interviews increased exposure prevalence from 16.9 to 22.2% for case mothers and 7.4 to 13.2% for control mothers. Accounting for this misclassification, the crude OR decreased by 24%, 1.9 (1.3, 2.7). CONCLUSIONS Though first trimester cigarette smoking was reported on birth certificates by more mothers of gastroschisis cases than controls, adjustment for confounders (maternal age and preconception BMI) and smoking misclassification suggests the association is weak. Despite a decrease in smoking prevalence among all women of childbearing years in Utah between 1997 and 2005, the prevalence of gastroschisis has not followed a similar trend.
p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

On the basis mainly of pharmacological experiments, the p38α MAP kinase isoform has been established as an important regulator of immune and inflammatory responses. However, the role of the related p38γ and p38δ kinases has remained unclear. Here, we show that deletion of p38γ and p38δ impaired the innate immune response to lipopolysaccharide (LPS), a Toll-like receptor 4 (TLR4) ligand, by blocking the extracellular signal-regulated kinase 1/2 (ERK1/2) activation in macrophages and dendritic cells. p38γ and p38δ were necessary to maintain steady-state levels of tumor progression locus 2 (TPL2), the MKK kinase that mediates ERK1/2 activation after TLR4 stimulation. TNFα, IL-1β, and IL-10 production were reduced in LPS-stimulated macrophages from p38γ/δ-null mice, whereas IL-12 and IFNβ production increased, in accordance with the known effects of TPL2/ERK1/2 signaling on the induction of these cytokines. Furthermore, p38γ/δ-deficient mice were less sensitive than controls to LPS-induced septic shock, showing lower TNFα and IL-1β levels after challenge. Together, our results establish p38γ and p38δ as key components in innate immune responses.
Large permutations and parameter testing

A classical theorem of Erdős, Lovasz and Spencer asserts that the densities of connected subgraphs in large graphs are independent. We prove an analogue of this theorem for permutations and we then apply the methods used in the proof to give an example of a finitely approximable permutation parameter that is not finitely forcible. The latter answers a question posed by two of the authors and Moreira and Sampaio.
Predicting Release Time for Open Source Software Based on the Generalized Software Reliability Model

There is a significant challenge that how to predict the possible release date of the target software having enough reliability in agile development where incremental development and small software releases are key characteristics. Existing approaches targeting agile development usually use release backlogs for predicting and setting delivery windows, however these do not consider the reliability of software for release date prediction so that there is a possibility that software at the predicted release date have poor reliability. Previously we proposed a generalized software reliability model (GSRM) based on a stochastic process and compared it with other models to evaluate recent software developments. However, we, did not directly evaluate the accuracy of the predicted release time by model. In this paper, towards prediction of release dates in agile development, we focus on the release dates of open source software (OSS) developments and the number of detected issues (faults) since OSS developments comply well with the definition of the agile development in terms of incremental process and frequent releases We define the accuracy of the predicted release time using the given development terms and the number of issues. Additionally, we propose a method to evaluate the accuracy of the predicted release time. In the best case, GSRM shows only 0.572% Error Rate, which corresponds to a predicted release date of two days prior to the actual release date. We believe that our method should be applicable to agile developments too.
Influence of a GSK3β phosphorylation site within the proximal C-terminus of Neurofilament-H on neurofilament dynamics

ABSTRACT Phosphorylation of the C-terminal tail of the heavy neurofilament subunit (NF-H) impacts neurofilament (NF) axonal transport and residence within axons by fostering NF-NF associations that compete with transport. We tested the role of phosphorylation of a GSK-3β consensus site (S493) located in the proximal portion of the NF-H tail in NF dynamics by transfection of NB2a/d1 cells with NF-H, where S493 was mutated to aspartic acid (S493D) or to alanine (S493A) to mimic constitutive phosphorylation and non-phosphorylation. S493D underwent increased transport into axonal neurites, while S493A displayed increased perikaryal NF aggregates that were decorated by anti-kinesin. Increased levels of S493A co-precipitated with anti-kinesin indicating that reduced transport of S493A was not due to reduced kinesin association but due to premature NF-NF interactions within perikarya. S493D displayed increased phospho-immunoreactivity within axonal neurites at downstream C-terminal sites attributable to mitogen-activated protein kinase and cyclin-dependent kinase 5. However, S493D was more prone to proteolysis following kinase inhibition, suggesting that S493 phosphorylation is an early event that alters sidearm configuration in a manner that promotes appropriate NF distribution. We propose a novel model for sidearm configuration. Summary: We demonstrate that phosphorylation of a critical site regulates neurofilament transport, proteolysis and interaction with other axonal cytoskeletal elements, and present evidence that it does so by altering protein conformation. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
c-Src Activation Mediates Erlotinib Resistance in Head and Neck Cancer by Stimulating c-Met

Purpose: Strategies to inhibit the EGF receptor (EGFR) using the tyrosine kinase inhibitor erlotinib have been associated with limited clinical efficacy in head and neck squamous cell carcinoma (HNSCC). Co-activation of alternative kinases may contribute to erlotinib resistance. Experimental Design: We generated HNSCC cells expressing dominant-active c-Src (DA-Src) to determine the contribution of c-Src activation to erlotinib response. Results: Expression of DA-Src conferred resistance to erlotinib in vitro and in vivo compared with vector-transfected control cells. Phospho-Met was strongly upregulated by DA-Src, and DA-Src cells did not produce hepatocyte growth factor (HGF). Knockdown of c-Met enhanced sensitivity to erlotinib in DA-Src cells in vitro, as did combining a c-Met or c-Src inhibitor with erlotinib. Inhibiting EGFR resulted in minimal reduction of phospho-Met in DA-Src cells, whereas complete phospho-Met inhibition was achieved by inhibiting c-Src. A c-Met inhibitor significantly sensitized DA-Src tumors to erlotinib in vivo, resulting in reduced Ki67 labeling and increased apoptosis. In parental cells, knockdown of endogenous c-Src enhanced sensitivity to erlotinib, whereas treatment with HGF to directly induce phospho-Met resulted in erlotinib resistance. The level of endogenous phospho-c-Src in HNSCC cell lines was also significantly correlated with erlotinib resistance. Conclusions: Ligand-independent activation of c-Met contributes specifically to erlotinib resistance, not cetuximab resistance, in HNSCC with activated c-Src, where c-Met activation is more dependent on c-Src than on EGFR, providing an alternate survival pathway. Addition of a c-Met or c-Src inhibitor to erlotinib may increase efficacy of EGFR inhibition in patients with activated c-Src. Clin Cancer Res; 19(2); 380–92. ©2012 AACR.
On a whitening approach to partial channel estimation and blind equalization of FIR/IIR multiple-input multiple-output channels

Channel estimation and blind equalization of multiple-input multiple-output (MIMO) communications channels is considered using primarily the second-order statistics of the data. Such models arise when a single receiver data from multiple sources is fractionally sampled (assuming that there is excess bandwidth) or when an antenna array is used with or without fractional sampling. We consider estimation of (partial) channel impulse response and design of finite-length minimum mean-square error (MMSE) blind equalizers. The basis of the approach is the design of a zero-forcing equalizer that whitens the noise-free data. We allow infinite impulse response (IIR) channels. Moreover, the multichannel transfer function need not be column reduced. Our approaches also work when the "subchannel" transfer functions have common zeros as long as the common zeros are minimum-phase zeros. The channel length or model orders need not be known. The sources are recovered up to a unitary mixing matrix and are further "unmixed" using higher order statistics of the data. A linear prediction approach is also considered under the above conditions of possibly IIR channels, common subchannel zeros/factors, and not-necessarily column reduced channels. Four illustrative simulation examples are provided.
Inhibitory effect of oolong tea polyphenols on glycosyltransferases of mutans Streptococci

Oolong tea extract (OTE) was found to inhibit the water-insoluble glucan-synthesizing enzyme, glucosyltransferase I (GTase-I), of Streptococcus sobrinus 6715. The GTase-inhibitory substance in the OTE was purified successive adsorption chromatography on Diaion HP-21 and HP-20 columns; this was followed by further purification by Sephadex LH-20 column chromatography. A major fraction that inhibited GTase activity (fraction OTF10) was obtained, and the chemical analysis of OTF10 indicated that it was a novel polymeric polyphenol compound that had a molecular weight of approximately 2,000 and differed from other tea polyphenols. Catechins and all other low-molecular-weight polyphenols except theaflavin derived from balck tea did not show significant GTase-inhibitory activities. It was found that OTE amd PTF10 markedly inhibit GTase-I and yeast alpha-glucosidase, but not salivary alpha-amylase. Various GTases purified from S. sobrinus and Streptococcus mutans were examined for inhibition by OTE and OTF10. It was determined that S. sobrinus GTase-I and S. mutans cell-free GTase synthesizing water-soluble glucan were most susceptible to the inhibitory action of OTF10, while S. sobrinus GTase-Sa and S. mutans cell-associated GTase were moderately inhibited; no inhibition of S. sobrinus GTase-Sb was observed. Inhibition of a specific GTase or specific GTases of mutants streptococci resulted in decreased adherence of the growing cells of these organisms. The inhibitory effect of OTF10 on cellular adherence was significantly stronger than that of OTE.