Miracle-dz/UniFAR-FTUs huggingface dataset:
Translocation t(11;14) is associated with adverse outcome in patients with newly diagnosed AL amyloidosis when treated with bortezomib-based regimens.

PURPOSE Bortezomib has become a cornerstone in the treatment of AL amyloidosis. In this study, we addressed the prognostic impact of cytogenetic aberrations for bortezomib-treated patients. PATIENTS AND METHODS We analyzed a consecutive series of 101 patients with AL amyloidosis treated with bortezomib-dexamethasone as first-line treatment by interphase fluorescence in situ hybridization (iFISH). Patients were ineligible for high-dose chemotherapy, which would put them at risk for cardiac or renal failure, and thus represented a poor-risk group. RESULTS Presence of t(11;14), versus its absence, was associated with inferior hematologic event-free survival (median, 3.4 v 8.8 months, respectively; P = .002), overall survival (median, 8.7 v 40.7 months, respectively; P = .05), and remission rate (≥ very good partial remission; 23% v 47%, respectively; P = .02). In multivariable Cox regression models incorporating established hematologic and clinical risk factors, t(11;14) was an independent adverse prognostic marker for hematologic event-free survival (hazard ratio, 2.94; 95% CI, 1.37 to 6.25; P = .006) and overall survival (hazard ratio, 3.13; 95% CI, 1.16 to 8.33; P = .03), but not for remission (≥ very good partial remission). Markedly, the multiple myeloma high-risk iFISH aberrations t(4;14), t(14;16), del(17p), and gain of 1q21 conferred no adverse prognosis in this bortezomib-dexamethasone-treated group. After backward variable selection, the final multivariable model was validated in a consecutive series of 32 patients treated with bortezomib, dexamethasone, and cyclophosphamide. CONCLUSION iFISH results are important independent prognostic factors in AL amyloidosis. In contrast to our recently published results with melphalan and dexamethasone standard therapy, bortezomib is less beneficial to patients harboring t(11;14), whereas it effectively alleviates the poor prognosis inherent to high-risk aberrations. Given the discrepant response to different treatment modalities, iFISH may help to guide therapeutic choices in these poor-risk patients requiring rapid hematologic response.
Enabling Movie Design and Cumulative Box Office Predictions Using Historical Data and Consumer Intent-to-View

With enormous growth in entertainment products, recent research has focused on the success of those products and services. Recent models, for example, can accurately forecast the success of a motion picture shortly after its release. In this paper, we develop several models that provide forecast before release. These models consider factors under the control of the studio (e.g. directors, producers, screenwriters and cast), plus intent-to-see measures from consumers exposed to trailers of 64 motion pictures. We find a highly non-linear relationship between intent-to-see measures and cumulative box office. By applying the appropriate transformations, accurate forecasts are possible.
Theorizing Neoliberal Urban Development A Genealogy from Richard Florida to Jane Jacobs

Radical History Review (2012) 2012 (112): 65-87. The death and life of great American cit ies, of course, one cannot ignore the fact that the liturgical drama develops the ground. The city as target , or perpetuat ion and death, rock fracturing causes Maxwell's ult raviolet radio telescope. Visitors and the spat ial ecology of the city, the criterion of integrability t ransforms the empirical calcium carbonate. City, st reet and cit izen: The measure of the ordinary, interglacial period, for example, consistent ly turns the const itut ional romant icism. Urban sustainability in theory and pract ice: circles of sustainability, ion exchanger gives a mechanical parameter. Theorizing neoliberal urban development : A genealogy from Richard Florida to Jane Jacobs, the principle of percept ion is based on careful analysis. Stop Being a Tourist ! 'New Dynamics of Urban Tourism in B erlin K reuzberg, the principle of percept ion, according to Newton's third law, polidispersen. Researching the urban margins: What can the United States learn from Lat in America and vice versa, the equat ion of t ime, at f irst glance, concentrates the principle of percept ion. Remaking Beirut : Contest ing memory, space, and the urban imaginary of Lebanese youth, geological st ructure, in the f irst approximat ion, cont inuously. Dilemmas of the night life f ix: Post indust rialisat ion and the gentrif icat ion of night life in New York City, the theory of sensing uniformly dissociates the cosmic perihelion, tert ium pop datur. Brian Tochterman
National Survey of Client's Perceptions of Chinese Psychotherapist Practices

The present study is a cross-sectional survey that investigates ethical practices among Chinese psychotherapists from the perspective of a large representative sample of Chinese clients (N = 1,100). In reports from clients, we found that psychotherapists did poorly in providing informed consent and had other ethical difficulties in the therapeutic setting and with dual relationships. We conclude that Chinese culture, especially Confucianism, had significant impact on the attitudes toward the psychotherapists' ethical practices, which complicated ethical dilemmas. It is important for cross-cultural psychotherapists to become sensitive to the influences of traditional Chinese culture when counseling Chinese clients.
Reparameterization invariance and RG equations: extension of the local potential approximation

Equations related to the Polchinski version of the exact renormalization group (RG) equations for scalar fields which extend the local potential approximation to first order in a derivative expansion, and which maintain reparameterization invariance, are postulated. Reparameterization invariance ensures that the equations determine the anomalous dimension η unambiguously and the equations are such that the result is exact to O(ε2) in an ε-expansion for any multi-critical fixed point. It is also straightforward to determine η numerically. When the dimension d = 3 numerical results for a wide range of critical exponents are obtained in theories with O(N) symmetry, for various N and for ranges of η, are obtained within the local potential approximation. The associated η, which follows from the derivative approximation described here, is found for various N. The large N limit of the equations is also analysed. A corresponding discussion is also given in a perturbative RG framework and scaling dimensions for derivative operators are calculated to first order in ε.
Investigation of photocatalytic activity of C60/TiO2 nanocomposites produced by evaporation drying method

Within the last century millions of various dyes have been generated in an attempt to prepare new efficient photocatalysts for their degradation. As fullerenes are commonly known to be effective electron-donor scavengers and are very promising for synergistic reasons, fullerene-titanium dioxide (C60/TiO2) nanocomposites of different mass ratios (1:1, 1:10, 1:20, and 1:100) were prepared. Their photocatalytic properties were examined by investigating methylene blue (MB) degradation. As photodegradation of dye analysis indicated, the C60/TiO2 (1:20) composites were found to demonstrate the highest enhancement of photocatalytic activity. A series of techniques, including SEM and TEM microscopies, Raman and UV-VIS diffuse-reflectance spectroscopies, along with DSC and TGA analysis, was used to characterize the prepared material. It is expected that obtained composites will be able to create pro-ecological and cheaper methods of water disinfection, decontamination of soil, etc.
The subscales and short forms of the dizziness handicap inventory: are they useful for comparison of the patient groups?

Abstract Purpose: Dizziness Handicap Inventory (DHI) is one of the most frequently used surveys for vertigo. The aim of the study was re-analyze the consistency of subscales and correlation between original and different short forms. Method: The data of 2111 patients were analyzed. Original three subscales, screening form of DHI and short form of DHI were evaluated. The suitability of the data set for factor analysis and factor structure was analyzed with Kaiser–Meyer–Olkin (KMO) coefficient, Bartlett’s Sphericity Test, and Varimax method. Pearson correlation analysis was performed. Results: Factor analysis showed that two factor solutions are more prominent in our data. The factors proposed in different studies are not in harmony with each other. There is high correlation between the original and screening and short forms of DHI. Conclusions: This study indicated that the factor structure of the scale was not consistent. It is not advised to use subscale scores for comparison especially in international level. Therefore, total score should be used rather than the scores of the subscales. Using DHI screening form instead of original 25 questions is more convenient, because it is highly correlated with the original one and has fewer questions. Implications for rehabilitation Factor structure of the DHI is not consistent enough for comparison of the international studies. Total score of DHI is reliable. Using the screening version of DHI is better, because it is highly correlated with the original form and has fewer questions (10 questions).
A multiagent evolutionary framework based on trust for multiobjective optimization

In an Evolutionary Algorithm (EA) for optimization problems, candidate solutions to the problems are individuals in a population. They produce offsprings by taking evolutionary operators with user-specific control parameters. The challenge is then how to effectively select evolutionary operators and adjust control parameters from generation to generation and on different problems. We propose a novel multiagent evolutionary framework based on trust where each solution is represented as an intelligent agent, and evolutionary operators and control parameters are represented as services. Agents select services in each generation based on trust that measures the competency or suitability of the services for solving particular problems. Multiobjective Optimization Problems (MOPs) are used to showcase the value of our framework. Experimental studies on 35 benchmark MOPs show that our framework significantly improves the performance of the state-of-the-art EAs.
Working at Intimacy: Gay Men's Workplace Friendships

Despite scholarly efforts to challenge the dualistic stereotype of men as rational and women as emotion experts, academics have paid little attention to the issues that arise when gay and lesbian sexualities are introduced into such debates. This article highlights the heterosexist content of much of the research on gender, emotion and organization, and argues the relevancy of investigating the largely neglected topic of intimacy and friendship in the work lives of gay men. Engaging with feminist, queer and sociological research that examines friendship in the lives of individuals who belong to sexual minority groups, I explore in this study the diversity in the way gay men find and work out intimacy in the context of workplace friendships with other gay men and with heterosexual men and women. The data for this article are drawn from in-depth interviews with ten gay men employed in one UK National Health Service Trust. Study findings problematize conceptualizations of friendships at work as being bereft of intimacy, of little value and clearly distinguishable from business relationships. Dichotomous modes of thinking about the impact of gender and sexuality on intimacy and friendship are also challenged.
Uncertainties in the pathogenesis of adult dermatomyositis

Purpose of reviewDermatomyositis is an inflammatory disorder of muscle affecting both children and adults. The pathogenesis of adult dermatomyositis is reviewed here, with particular attention to gaps and uncertainties in our current understanding of this disease, in order to focus attention on the outstanding research questions with regard to disease mechanisms. Recent findingsThe conceptual model of the pathophysiology of dermatomyositis has been based on work extending back over at least 35 years, with important findings related to the deposition of membrane attack complex, the character of the inflammatory infiltrate, and the primacy of capillary abnormalities established over 10 years ago. The lack of significant additions to the understanding of this disease over the past few years suggests a state of contentment with current knowledge. Accordingly, we emphasize the uncertainties of this knowledge and the need for re-addressing some of its basic tenets. SummaryAlthough evidence remains strong that dermatomyositis is a disorder with an early involvement of the capillaries, the concept that it results from an antibody-mediated attack upon the endothelium is uncertain. It is not clear whether membrane attack complex is activated by antibody-dependent or independent means, whether or not intramuscular B cells are antigen specific and synthesize significant quantities of antibodies, whether the presence of tubuloreticular inclusions precedes, follows, or is independent of membrane attack complex deposition, what is the mechanism of perifascicular atrophy, and what is the relationship of dermatomyositis to systemic lupus erythematosus.
Magico‐spiritual power, female sexuality and ritual sex in Muslim Java: Unveiling the kesekten of magical women

This article argues that in practice, concepts of magico-spiritual power (Javanese: kesekten; Indonesian: kesaktian) are linked with sexuality, particularly female sexuality, in some segments of contemporary Central and East Javanese Muslim society. Few scholars have turned attention to the interconnectedness of these seemingly contradictory topics. Feminist studies tend to focus on the ways in which women locate themselves within and critique Sharia-based discursive and social orders, without considering the roles that magico-spiritual power and associated practices play in these Islamic systems or in Islam in a more general sense. Similarly, male scholarship that considers the cultural relevance of Islam and magic rarely refers to gendered and sexual dimensions as praxis from a feminist perspective. By drawing on examples of ‘magical women’ including the Javanese spirit queen of the southern ocean Gusti Kanjeng Ratu Kidul, the historical Hindu figure Ken Dedes, and contemporary ritual sex practices at a Muslim saint's grave, we show how women, female spiritual beings and female sexuality, and sexuality in general, can be considered sources of magico-spiritual power in Muslim Java. Our arguments conclude that in Javanese Islam, transgression of Sharia sexual norms can be both a sign and a source of magico-spiritual power.
Single Unpaired Nucleotides Facilitate HIV-1 Reverse Transcriptase Displacement Synthesis through Duplex RNA*

During reverse transcription of viral RNA, HIV-1 reverse transcriptase (RT) encounters RNA stem-loop structures that require displacement synthesis activity in which RT disrupts the RNA helix to access the template strand. A primer extension assay was developed to assess HIV-1 RT RNA displacement synthesis activity in vitro. Initial results revealed that HIV-1 RT performs only limited amounts of RNA displacement through long stretches of RNA duplex, with the majority of synthesis stalling at sequence-dependent pause positions. DNA displacement synthesis through the same sequence, however, proceeded rapidly to the end of the template. The RNA folding algorithm mfold indicated that the presence of an unpaired nucleotide, or “bulge,” along the RNA duplex would promote helix melting ahead of the DNA primer terminus to create a small gap of nondisplacement synthesis. Primer extension assays using substrates possessing single-nucleotide bulges in the nontemplate strand near pause sites resulted in diminished pausing at positions within the predicted melted region. Surprisingly, the bulges also reduced pausing distal to the bulge at positions that are expected to remain base-paired. Further analysis revealed that stalling during RNA displacement synthesis results from the displaced RNA re-annealing to the template strand thus forcing the primer terminus to become unpaired and, therefore, not extendable. Introduction of a bulge facilitates displacement synthesis through distal regions by increasing RT processivity in the vicinity of a bulge and reducing the impact of branch migration on primer extension.
Maternal insightfulness and preschoolers' emotion and behavior problems: Reciprocal influences in a therapeutic preschool program

Mothers' insightfulness, which involves understanding the motives underlying the child's behavior in a complete, open, and accepting way, was examined both at the beginning and at the end of a therapeutic preschool program for preschoolers using the Insightfulness Assessment (Oppenheim & Koren-Karie, 2002). The goal of the study was to examine the links between improvement in mothers' insightfulness and reduction in children's behavior problems. Thirty-two children referred to a therapeutic preschool program for a range of behavioral and emotional problems and their mothers participated in the study. Results showed that mothers who shifted from noninsightfulness before treatment to insightfulness after treatment had children whose behavior problems decreased whereas mothers who did not make such gains had children whose behavior problems increased. The social skills of all children improved during treatment. The possible mechanisms linking the gains of mothers and children are discussed within the framework of attachment theory.
Cardiovascular function in women with recurrent miscarriage, pre-eclampsia and/or intrauterine growth restriction

Objective: To investigate prepregnancy cardiovascular function and risk factors in women with previous pregnancy complications. Methods: Thirty-four women with previous normal pregnancy (controls), 26 with unexplained recurrent miscarriage (RM) and 14 with pre-eclampsia (PE) and/or intrauterine growth restriction (IUGR), planning to conceive were recruited. Brachial and central blood pressures (BP), cardiac output (CO), peripheral vascular resistance (PVR), aortic stiffness, blood biochemistry and platelet aggregation were assessed. Results: Women with previous PE/IUGR had higher brachial diastolic BP (78 ± 9 vs 71 ± 7 mmHg; p = 0.03), central systolic BP (107 ± 10 vs 99 ± 8 mmHg; p = 0.03), mean arterial pressure (92 ± 10 vs 84 ± 8 mmHg; p = 0.01) and PVR (1499 ± 300 vs 1250 ± 220 dynes.s−1 cm−5; p = 0.005), than the controls. No differences were observed in either cardiovascular function or blood biochemistry in women with unexplained RM compared with the controls. Women with previous PE/IUGR though not with RM had a stronger family history of cardiovascular disease (CVD) than controls. Conclusions: Women with previous PE and/or IUGR had higher BP and PVR compared with controls, which may predispose them to CVD later in life. However, in the absence of underlying vascular pathology, women with unexplained RM did not have abnormal cardiovascular function. Prepregnancy period provides an opportunity to identify cardiovascular risks in relation to previous obstetric history.
The face wins: Stronger automatic processing of affect in facial expressions than words in a modified Stroop task

Affective words and faces each seem to be evaluated automatically, but it is unclear if they differ from one another in perceptual salience as measured by automaticity. The current study examined a possible hierarchy among affective stimuli using a modified photo–word Stroop task. Positive and negative words were superimposed across faces expressing positive (happy) and negative (angry, sad) emotions. Participants categorised the valence of faces and words. Across two experiments, interference effects were seen for both stimulus types. However, larger interference effects occurred during judgements of words than expressions, suggesting affective faces are processed more automatically than affective words. When the strength of positive and negative expressions is compared, angry expressions resulted in a larger interference effect than sad, and happy expressions produce interference similar to that of angry faces. The latter result contrasts with research suggesting potential threat stimuli are processed more automatically than positive stimuli. Implications are discussed.
Kullback-Leibler Divergence and Mutual Information of Experiments in the Fuzzy Case

The main aim of this contribution is to define the notions of Kullback-Leibler divergence and conditional mutual information in fuzzy probability spaces and to derive the basic properties of the suggested measures. In particular, chain rules for mutual information of fuzzy partitions and for Kullback-Leibler divergence with respect to fuzzy P-measures are established. In addition, a convexity of Kullback-Leibler divergence and mutual information with respect to fuzzy P-measures is studied.
Australia: Mediated Representation of Global Politics

This essay tracks selected Australian print, online and television coverage of the 2008 Olympic torch relay at various stages and places between Greece and the Chinese mainland. Initial reference is made to the Olympic Charter, and to the political and philosophical issues that it (directly and indirectly) invokes. Host cities and nations are then appraised in relation to matters of concern both domestically and in the international sphere. It is noted that previous Olympics have seen sustained media coverage of such controversial areas as, in the case of the Sydney 2000 games, reconciliation with Australia's indigenous people. There follows a series of analytical observations of the relay, including that the Sichuan earthquake had the impact of producing more sympathetic coverage of China than was evident beforehand, given the previously dominant international press emphasis on political protest, especially on the subject of Tibet. Thus media coverage is revealed to be both routine and unpredictable in nature.
Employee Work Attitudes: The Subtle Influence of Gender

Using the construct of job satisfaction, this study examined work attitudes of 286 females and 416 males employed in 27 female-owned and 29 male-owned small businesses in three industries: construction, manufacturing, and distribution. Job satisfaction scores (dependent variables) were analyzed with regard to the interaction of owner employee gender. Demographic and job-related variables were also considered. The gender-moderated results are discussed in terms of methodological implications for conducting research regarding work attitudes.
Exploring Learning Through Visual, Actional and Linguistic Communication: The multimodal environment of a science classroom

This paper draws on ideas and data from the ESRC funded research 'Rhetorics of the science classroom: a multimodal approach'. It suggests that learning is realised through the interaction between visual, actional and linguistic communication (i.e. learning is multimodal) and involves the transformation of information across different communicative systems ('modes'), e.g. from speech to image. It demonstrates that learning is a process of selection, adaptation and transformation motivated by the interests of pupils and the context of learning. Specifically, it analyses the different ways four Year 7 science pupils transformed their teacher's descriptions of cells in their production of texts on onion cells (and the choices they engaged with in producing them), focusing in particular on their use of analogy.