Miracle-dz/UniFAR-FTUs huggingface dataset:
Revealing Unreported Benefits of Digital Water Metering: Literature Review and Expert Opinions

Digital water meters can take Australian water utilities into the world of internet of things (IoT) and big data analytics. The potential is there for them to build more efficient processes, to enable new products and services to be offered, to defer expensive capital works, and for water conservation to be achieved. However, utilities are not mounting business cases with sufficient benefits to cover the project and operational costs. This study undertakes a literature review and interviews of industry experts in the search for unreported benefits that might be considered for inclusion in business cases. It identifies seventy-five possible benefits of which fifty-seven are classified as benefiting the water utility and forty are classified as benefiting customers (twenty-two benefit both). Many benefits may be difficult to monetize. Benefits to customers may have a small monetary benefit to the water utility but provide a significant benefit to customer satisfaction scores. However, for utilities to achieve these potential benefits, eight change enablers were identified as being required in their systems, processes, and resources. Of the seventy-five benefits, approximately half might be considered previously unreported. Finally, a taxonomy is presented into which the benefits are classified, and the enabling business changes for them to be realized are identified. Water utilities might consider the taxonomy, the benefits, and the changes required to enable the benefits when developing their business cases.
Pilot Initiatives of Adult Hearing Screening in Italy

A series of pilot initiatives of adult hearing screening programs were organized in eight large and small-size cities in Italy in the past two years. The screening initiatives were held in public places, supermarkets, drugstores, and in some universities of the third age, and involved an overall population of 2,278 screened subjects with age ranging from 13 to 93 years. Three different screening tests were used to assess hearing ability in the participants, i.e.: screening pure tone audiometry (PTA), an automated speech-in-noise screening test (the SUN-test), and a screening questionnaire of self-perceived hearing handicap (the HHIE-S). This paper describes the organization and management of these screening initiatives and reviews the main results obtained in the screened population, using the three different screening tests. Results obtained in these pilot initiatives showed that screening adults for hearing problems might be feasible, on a local level, in non clinical settings and can be performed quite easily with the support of local coordinators and partners, such as associations or local authorities. It is recognized that further initiatives and studies will have to be performed to better define the key aspects related to the organization and management of adult hearing screening programs, either at a local, regional, or national level.
Protein synthesis is lowered while 20S proteasome activity is maintained following acclimation to low temperature in juvenile spotted wolffish (Anarhichas minor Olafsen)

SUMMARY The effects of temperature on protein metabolism have been studied mostly with respect to protein synthesis. Temperature generally has a parabolic effect on protein synthesis with a maximum rate being observed at optimal growth temperature. The effect of temperature on protein degradation is poorly understood. The 20S proteasome is mainly responsible for the degradation of short-lived and oxidatively modified proteins and has been recently identified as a potentially good proxy for protein degradation in fish. The aim of this experiment was to examine the relationships between the rate of protein synthesis, activity of the 20S proteasome, oxidative stress markers and antioxidant capacity in white muscle of juvenile spotted wolffish (Anarhichas minor) acclimated at three temperatures (4, 8 and 12°C). The rate of protein synthesis was lower at 4°C than at 8°C while it was intermediate at 12°C. Despite the decrease of protein synthesis at low temperature, the activity of 20S proteasome activity was maintained high in fish acclimated at lower temperature (4°C), reaching levels 130% of that of fish acclimated at 8°C when measured at a common temperature. The oxidative stress markers TBARS and protein-carbonyl content did not change among temperature groups, but reduced glutathione concentration was higher in cold-acclimated fish, suggesting a higher antioxidant capacity in this group. Our data suggest that lower growth rate in cold temperature results from both high 20S proteasome activity and a reduced rate of protein synthesis.
Statistical Models and Algorithms for Studying Hand and Finger Kinematics and their Neural Mechanisms

The primate hand, a biomechanical structure with over twenty kinematic degrees of freedom, has an elaborate anatomical architecture. Although the hand requires complex, coordinated neural control, it endows its owner with an astonishing range of dexterous finger movements. Despite a century of research, however, the neural mechanisms that enable finger and grasping movements in primates are largely unknown. In this thesis, we investigate statistical models of finger movement that can provide insights into the mechanics of the hand, and that can have applications in neural-motor prostheses, enabling people with limb loss to regain natural function of the hands. There are many challenges associated with (1) the understanding and modeling of the kinematics of fingers, and (2) the mapping of intracortical neural recordings into motor commands that can be used to control a Brain-Machine Interface. These challenges include: potential nonlinearities; confounded sources of variation in experimental datasets; and dealing with high degrees of kinematic freedom. In this work we analyze kinematic and neural datasets from repeated-trial experiments of hand motion, with the following contributions: • We identified static, nonlinear, low-dimensional representations of grasping finger motion, with accompanying evidence that these nonlinear representations are better than linear representations at predicting the type of object being grasped over the course of a reach-to-grasp movement. In addition, we show evidence of better encoding of these nonlinear (versus linear) representations in the firing of some neurons collected from the primary motor cortex of rhesus monkeys. • A functional alignment of grasping trajectories, based on total kinetic energy, as a strategy to account for temporal variation and to exploit a repeated-trial experiment structure. • An interpretable model for extracting dynamic synergies of finger motion, based on Gaussian Processes, that decomposes and reduces the dimensionality of variance in the dataset. We derive efficient algorithms for parameter estimation, show accurate reconstruction of grasping trajectories, and illustrate the interpretation of the model parameters. • Sound evidence of single-neuron decoding of interpretable grasping events, plus insights about the amount of grasping information extractable from just a single neuron. • The Laplace Gaussian Filter (LGF), a deterministic approximation to the posterior mean that is more accurate than Monte Carlo approximations for the same computational cost, and that in an off-line decoding task is more accurate than the standard Population Vector Algorithm. To Jon Huang, without whose faith, encouragement and support the completion of this journey would have been unthinkable.
The same old process? Older people, participation and deliberation

Opportunities for older people to take part in decision making about public policies and services are expanding in the United Kingdom and elsewhere. This paper considers the potential of older people's participation in policy processes for both transforming the policy process and for achieving socially just outcomes. It argues that the way in which such participation takes place, in particular the nature of the deliberative processes, affects both who will feel able to take part and the capacity to develop new policy discourses which can challenge official perspectives and assumptions. It draws from critical perspectives on deliberative democracy to provide a theoretical framework. This work emphasises the importance of story telling and forms of exchange designed to offer recognition to others, as well as the rational argument more usually associated with deliberation on matters of public policy. The argument is illustrated with examples of participation initiatives that have involved ‘active’ older people and those who are users of social care services. Different styles and processes of exchange are distinguished in the three case studies. In one, active facilitation enables individual stories of ageing and of service use to be woven into collective narratives that offer an alternative vision of care services. In another, a strong emphasis on ‘greeting’ enables conflicting views to be expressed without participants falling out. In the third, styles of exchange familiar in formal debate limit the development of an alternative discourse. The conclusion suggests that attention needs to be given to the process of participation as well as to outcomes.
Fractionation of the Three Stable Oxygen Isotopes by Oxygen-Producing and Oxygen-Consuming Reactions in Photosynthetic Organisms1[w]

The triple isotope composition (δ17O and δ18O) of dissolved O2 in the ocean and in ice cores was recently used to assess the primary productivity over broad spatial and temporal scales. However, assessment of the productivity with the aid of this method must rely on accurate measurements of the 17O/16O versus 18O/16O relationship in each of the main oxygen-producing and -consuming reactions. Data obtained here showed that cleavage of water in photosystem II did not fractionate oxygen isotopes; the δ18O and δ17O of the O2 evolved were essentially identical to those of the substrate water. The fractionation slopes for the oxygenase reaction of Rubisco and respiration were identical (0.518 ± 0.001) and that of glycolate oxidation was 0.503 ± 0.002. There was a considerable difference in the slopes of O2 photoreduction (the Mehler reaction) in the cyanobacterium Synechocystis sp. strain PCC 6803 (0.497 ± 0.004) and that of pea (Pisum sativum) thylakoids (0.526 ± 0.001). These values provided clear and independent evidence that the mechanism of O2 photoreduction differs between higher plants and cyanobacteria. We used our method to assess the magnitude of O2 photoreduction in cyanobacterial cells maintained under conditions where photorespiration was negligible. It was found that electron flow to O2 can be as high as 40% that leaving photosystem II, whereas respiratory activity in the light is only 6%. The implications of our findings to the evaluation of specific O2-producing or -consuming reactions, in vivo, are discussed.
Discovery Strategies of Bioactive Compounds Synthesized by Nonribosomal Peptide Synthetases and Type-I Polyketide Synthases Derived from Marine Microbiomes

Considering that 70% of our planet’s surface is covered by oceans, it is likely that undiscovered biodiversity is still enormous. A large portion of marine biodiversity consists of microbiomes. They are very attractive targets of bioprospecting because they are able to produce a vast repertoire of secondary metabolites in order to adapt in diverse environments. In many cases secondary metabolites of pharmaceutical and biotechnological interest such as nonribosomal peptides (NRPs) and polyketides (PKs) are synthesized by multimodular enzymes named nonribosomal peptide synthetases (NRPSes) and type-I polyketide synthases (PKSes-I), respectively. Novel findings regarding the mechanisms underlying NRPS and PKS evolution demonstrate how microorganisms could leverage their metabolic potential. Moreover, these findings could facilitate synthetic biology approaches leading to novel bioactive compounds. Ongoing advances in bioinformatics and next-generation sequencing (NGS) technologies are driving the discovery of NRPs and PKs derived from marine microbiomes mainly through two strategies: genome-mining and metagenomics. Microbial genomes are now sequenced at an unprecedented rate and this vast quantity of biological information can be analyzed through genome mining in order to identify gene clusters encoding NRPSes and PKSes of interest. On the other hand, metagenomics is a fast-growing research field which directly studies microbial genomes and their products present in marine environments using culture-independent approaches. The aim of this review is to examine recent developments regarding discovery strategies of bioactive compounds synthesized by NRPS and type-I PKS derived from marine microbiomes and to highlight the vast diversity of NRPSes and PKSes present in marine environments by giving examples of recently discovered bioactive compounds.
Ethics under uncertainty: the morality and appropriateness of utilitarianism when outcomes are uncertain.

Real-life moral dilemmas inevitably involve uncertainty, yet research has not considered how uncertainty affects utilitarian moral judgments. In addition, even though moral dilemma researchers regularly ask respondents, "What is appropriate? " but interpret it to mean, "What is moral? ," little research has examined whether a difference exists between asking these 2 types of questions. In this study, 140 college students read moral dilemmas that contained certain or uncertain consequences and then responded as to whether it was appropriate and whether it was moral to kill 1 to save many (a utilitarian choice). Ratings of the appropriateness and morality of the utilitarian choice were lower under uncertainty than certainty. A follow-up experiment found that these results could not be explained entirely by a change in the expected values of the outcomes or a desire to avoid the worst-case scenario. In addition, the utilitarian choice to kill 1 to save many was rated as more appropriate than moral. The results imply that moral decision making may depend critically on whether uncertainties in outcomes are admitted and whether people are asked about appropriateness or morality.
STAGES IN THE ORIGIN OF VERTEBRATES: ANALYSIS BY MEANS OF SCENARIOS

Vertebrates lack an epidermal nerve plexus. This feature is common to many invertebrates from which vertebrates differ by an extensive set of shared‐derived characters (synapomorphies) derived from the neural crest and epidermal neurogenic placodes. Hence, the hypothesis that the developmental precursor of the epidermal nerve plexus may be homologous to the neural crest and epidermal neurogenic placodes. This account attempts to generate a nested set of scenarios for the prevertebrate‐vertebrate transition, associating a presumed sequence of behavioural and environmental changes with the observed phenotypic ones. Toward this end, it integrates morphological, developmental, functional (physiological/behavioural) and some ecological data, as many phenotypic shifts apparently involved associated transitions in several aspects of the animals. The scenarios deal with the origin of embryonic and adult tissues and such major organs as the notochord, the CNS, gills and kidneys and propose a sequence of associated changes. Alternative scenarios are stated as the evidence often remains insufficient for decision. The analysis points to gaps in comprehension of the biology of the animals and therefore suggests further research.
Effectively Educating Latino/a Students

This article provides, first, a brief review of literature concerning the education of Hispanic American (Latino/a) students at the secondary and postsecondary levels and, second, the results of questionnaire research conducted with Latino/a and Anglo-American (White) students at a large university in the Southwest regarding classroom participation patterns. Latino/a students' responses reflected traditional Hispanic values (i.e., community and cooperation) when compared to White students' responses. However, intriguing similarities and counterintuitive responses from each group resulted as well. n: Este manuscrito provee en primer lugar una revisión de la literatura en cuanto a la educación de estudiantes hispano-americanos (latinos) a nivel secundario y terciario; en segundo lugar los resultados de un cuestionario de investigación con estudiantes latinos y anglo-americanos (blancos) en una universidad en el suroeste con respecto a los patrones de participación en salones de clase. Las respuestas de los estudiantes latinos reflejaron valores hispanos tradicionales como comunidad y cooperación al compararse con las respuestas de los estudiantes blancos. Sin embargo, también se encontraron en ambos grupos respuestas con similitudes intrigantes y contra-intuitivas.
Effective Treatment of Poststroke Depression With the Selective Serotonin Reuptake Inhibitor Citalopram

Background and Purpose The aim of the study was to investigate the efficacy and safety of the selective serotonin reuptake inhibitor citalopram in treating poststroke depression, since available treatments are usually poorly tolerated. Methods A 6-week double-blind, placebo-controlled trial was undertaken. Diagnosis and outcome were determined using the Hamilton Depression Scale, and unwanted effects were measured using the UKU side effect rating scale. Sixtysix consecutive depressed patients from an unselected population of 285 stroke patients aged 25 to 80 years entered the trial 2 to 52 weeks after stroke. They were assigned to equally sized treatment and placebo groups. The initial level of depression was comparable in the two groups (mean baseline Hamilton Depression scores, 19.4 and 18.9, respectively). Demographic parameters were also comparable in the two groups. Results Significantly greater improvement was seen in patients treated with citalopram (10 to 40 mg/d) for 3 and 6 weeks, both when including all patients (intention-to-treat analysis, p<.05) and excluding patients who dropped out during the first 3 weeks (efficacy analysis, P<.005). Half of the 28 patients who entered the trial 2 to 6 weeks after stroke recovered within 1 month, independent of the treatment given. This indicates a high degree of spontaneous recovery in the early phase after stroke. In contrast, recovery was infrequent in placebo group patients who became depressed 7 weeks or more after stroke. No serious side effects related to the treatment were detected; those present were mild and usually transient. Conclusions This trial demonstrates that the selective serotonin reuptake inhibitor citalopram offers an advantageous new treatment of poststroke depression that is both safe and effective.
The impact of project-based learning on self-directed learning readiness

All incoming students at the University of Calgary’s Schulich School of Engineering take a first year Design and Communication course that requires them to work in teams of 4 on a number of openended design projects. The projects require students to be persistent, self-disciplined, and curious, while carefully organizing and pacing themselves to reach their end goal. In this paper, we use the Self-directed Learning Readiness Scale (SDLRS) survey to determine if, by practicing these skills, students’ selfdirected learning readiness is improved. We compare a compare a new cohort of first-year engineering students with a cohort of first-years students with project-based learning experience. The results suggest that project-based learning experiences do have a positive impact on self-directed learning readiness.
Holding in Mind: Intersubjectivity, Subject Relations and the Group

Intersubjectivity, the intersection of two (or more) subjectivities, is emerging as a key concept in psychoanalysis. The intersubjective perspective stands in contrast to classical psychoanalytic theorizing and implies that much current thinking about subjectivity and objectivity needs revisiting. Views on subjectivity within philosophy, developmental psychology and psychoanalysis have much to offer group analysis (and, one suspects, vice versa). The everyday assumption that our subjectivity is essentially private is challenged. The article takes a fresh look at the notion of countertransference and emphasizes the group conductor's subjectivity as crucially constitutive of the group process.
The significance of serum xanthine oxidoreductase in patients with nonalcoholic fatty liver disease.

BACKGROUND Serum uric acid levels are significantly associated with nonalcoholic fatty liver disease (NAFLD). Xanthine oxidoreductase (XOR) is the key enzyme that catalyzes the formation of uric acid. The aim of this study was to investigate the association between serum XOR activity and NAFLD. METHODS In this cross-sectional study, serum XOR activity was measured by enzyme-linked immunosorbent assay in 129 patients with NAFLD and 71 controls. RESULTS Serum XOR activity was markedly higher in patients with NAFLD than in the controls (p < 0.001). Serum XOR activity positively correlated with markers of liver injury and indices of oxidative stress. Moreover, patients with high XOR activity had a higher prevalence of metabolic syndrome. CONCLUSIONS These data show that serum XOR activity is significantly associated with NAFLD.
Brillouin Corrosion Expansion Sensors for Steel Reinforced Concrete Structures Using a Fiber Optic Coil Winding Method

In this paper, a novel kind of method to monitor corrosion expansion of steel rebars in steel reinforced concrete structures named fiber optic coil winding method is proposed, discussed and tested. It is based on the fiber optical Brillouin sensing technique. Firstly, a strain calibration experiment is designed and conducted to obtain the strain coefficient of single mode fiber optics. Results have shown that there is a good linear relationship between Brillouin frequency and applied strain. Then, three kinds of novel fiber optical Brillouin corrosion expansion sensors with different fiber optic coil winding packaging schemes are designed. Sensors were embedded into concrete specimens to monitor expansion strain caused by steel rebar corrosion, and their performance was studied in a designed electrochemical corrosion acceleration experiment. Experimental results have shown that expansion strain along the fiber optic coil winding area can be detected and measured by the three kinds of sensors with different measurement range during development the corrosion. With the assumption of uniform corrosion, diameters of corrosion steel rebars were obtained using calculated average strains. A maximum expansion strain of 6,738 με was monitored. Furthermore, the uniform corrosion analysis model was established and the evaluation formula to evaluate mass loss rate of steel rebar under a given corrosion rust expansion rate was derived. The research has shown that three kinds of Brillouin sensors can be used to monitor the steel rebar corrosion expansion of reinforced concrete structures with good sensitivity, accuracy and monitoring range, and can be applied to monitor different levels of corrosion. By means of this kind of monitoring technique, quantitative corrosion expansion monitoring can be carried out, with the virtues of long durability, real-time monitoring and quasi-distribution monitoring.
Glandular neoplasia of the lung. A proposed analogy to colonic tumors

In 62 consecutive resections for adenocarcinoma of the lung, 50 cases (81%) had single adenocarcinomas and 12 (19%) had multiple adenocarcinomas. In seven of these 12 patients, two adenocarcinomas were found. In the other five patients, the specimen contained a dominant adenocarcinoma and several 0.1‐ to 1‐cm nodules of similar histologic appearance. In four of the 50 single tumor patients and one of seven double tumor patients, 1‐ to 2‐mm nodules were found along with adenocarcinomas that we interpreted as being bronchioloalveolar tumors of uncertain malignant potential. An analogy is drawn between these four types of findings and single tumors of the colon, double tumors of the colon, polyposis syndromes, and tubular adenomas of the colon, respectively.