Miracle-dz/UniFAR-FTUs huggingface dataset:
Detecting Significant Events in Lecture Video using Supervised Machine Learning

This paper describes work we are doing to identify significant events in video captures of academic lectures. Unlike other approaches which tend to define per-image comparison threshold values based on intuition or empirically derived results, we use supervised machine learning techniques to automatically determine appropriate image characteristics based on end-users understanding of what constitutes an important event. This makes our approach more adaptable to different kinds of content, and still provides a substantial level of agreement with human experts.
Adverse Childhood and Recent Negative Life Events

Objective: To examine whether persons who experienced adverse childhood events or recent negative life events have a worse cognitive performance and faster cognitive decline and the role of depression and apolipoprotein E-∊4 in this relationship. Methods: The community-based sample consisted of 10-year follow-up data of 1312 persons participating in the Longitudinal Aging Study Amsterdam (age range 65-85 years). Results: Persons who experienced adverse childhood events showed a faster 10-year decline in processing speed but only when depressive symptoms were experienced. Persons with more recent negative life events showed slower processing speed at baseline but no faster decline. Conclusions: Childhood adversity may cause biological or psychological vulnerability, which is associated with both depressive symptoms and cognitive decline in later life. The accumulation of recent negative life events did not affect cognitive functioning over a longer time period.
Time course of plasma and pulmonary lymph endothelin-like immunoreactivity during sustained endotoxaemia in chronically instrumented sheep.

1. Endothelin, a novel vasoconstrictor 21-residue peptide isolated from the supernatant of cultured porcine endothelial cells, has been shown to be increased in plasma in a variety of cardiovascular disease states, including acute myocardial infarction, acute renal failure and essential hypertension. We determined the time course of plasma and pulmonary lymph endothelin-like immunoreactivity in relation to the progressive deterioration of cardiopulmonary function in an ovine septic shock model leading to multi-organ failure syndrome and death within 42 h of a continuous intravenous infusion of Escherichia coli endotoxin (40 ng min-1kg-1). 2. Plasma and pulmonary lymph endothelin-like immunoreactivity were measured by r.i. a. using a specific antiserum raised in rabbits against porcine endothelin-1. Endothelin-like immunoreactivity was further determined in lung tissue and the thoracic duct lymph of endotoxin-treated sheep by reversed-phase h.p.l.c. In control instrumented conscious sheep not infused with endotoxin, there were no significant changes in any of the measured cardiopulmonary and biochemical variables, with plasma and pulmonary lymph endothelin-like immunoreactivity remaining below the detection limit (less than 1 pg/tube) throughout the 72 h study period. 3. Conscious sheep receiving endotoxin showed a major hypotensive septic syndrome, including persistently decreased systemic blood pressure, systemic vascular resistance, stroke volume, left ventricular stroke work, associated with sustained pulmonary vasoconstriction and protein-rich pulmonary oedema (greater than five-fold increase in pulmonary lymph flow and protein clearance), and marked lactic acidosis, leading to the death of animals within 14-42 h despite institution of mechanical ventilation and adequate intravascular volume replacement. (ABSTRACT TRUNCATED AT 250 WORDS)
Variation in small sapling density, understory cover, and resource availability in four neotropical forests

Even though many forest plants spend all or a significant portion of their lives in the forest understory, few studies have compared understory composition, structure, and resource availability among forests. We used standardized transect-based methods to compare small sapling densities (10-50 cm tall), understory vegetation cover, canopy openness, and nutrient availability in non-gap portions of four lowland Neotropical forests: La Selva, Costa Rica (LS), Barro Colorado Island, Panama (BCI), Cocha Cashu, Peru (CC), and north of Manaus, Brazil (KM41). Sites differed significantly in all variables except canopy openness. LS had high palm and non-fern herb cover and low density of small saplings (0.7-1.6/m2) compared to other sites. CC had high fern cover, whereas BCI had low cover in all categories of understory vegetation (palms, ferns, and non-fern herbaceous plants). BCI, CC, and KM41 had similar small sapling densities, ranging from 4.8-7.5/m2. Within each forest, cation (Ca, Mg, K, and Na) availability was usually higher on more fertile soil orders (Inceptisols, Alfisols, and Entisols) than on more weathered soil types (Ultisols and Oxisols). Extractable P was highest at LS and CC and lowest on BCI (no data for KM41). Spatial autocorrelation was present for some variables in some transects to distances beyond our detection ability (>25 m). Understory palm cover was negatively correlated with small sapling density at fine ( 1 m2 quadrat) and coarse spatial scales (among forests), although across forests the effect of palms was due entirely to the difference between LS and the other three forests. These results provide cross-site support for the hypothesis that understory cover by palms decreases the density of small saplings that comprise the advance regeneration of the forest. 0 F
Associative Learning Beyond the Medial Temporal Lobe: Many Actors on the Memory Stage

Decades of research have established a model that includes the medial temporal lobe, and particularly the hippocampus, as a critical node for episodic memory. Neuroimaging and clinical studies have shown the involvement of additional cortical and subcortical regions. Among these areas, the thalamus, the retrosplenial cortex, and the prefrontal cortices have been consistently related to episodic memory performance. This article provides evidences that these areas are in different forms and degrees critical for human memory function rather than playing only an ancillary role. First we briefly summarize the functional architecture of the medial temporal lobe with respect to recognition memory and recall. We then focus on the clinical and neuroimaging evidence available on thalamo-prefrontal and thalamo-retrosplenial networks. The role of these networks in episodic memory has been considered secondary, partly because disruption of these areas does not always lead to severe impairments; to account for this evidence, we discuss methodological issues related to the investigation of these regions. We propose that these networks contribute differently to recognition memory and recall, and also that the memory stage of their contribution shows specificity to encoding or retrieval in recall tasks. We note that the same mechanisms may be in force when humans perform non-episodic tasks, e.g., semantic retrieval and mental time travel. Functional disturbance of these networks is related to cognitive impairments not only in neurological disorders, but also in psychiatric medical conditions, such as schizophrenia. Finally we discuss possible mechanisms for the contribution of these areas to memory, including regulation of oscillatory rhythms and long-term potentiation. We conclude that integrity of the thalamo-frontal and the thalamo-retrosplenial networks is necessary for the manifold features of episodic memory.
An Algorithm to Find the Irreducible Polynomials Over Galois Field GF(pm)

Irreducible Polynomials over GF(p) and the multiplicative inverses under it are important in cryptography. Presently the method of deriving irreducible polynomials of a particular prime modulus is very primitive and time consuming. In this paper, in order to find all irreducible polynomials, be it monic or non-monic, of all prime moduli p with all its order m, a fast deterministic computer algorithm based on an algebraic method producing a (m×m) matrix is proposed. The maximum number of terms in each column of the matrix is 2 where j is the column index. General Terms Algorithms, Irreducible polynomial.
An empirical study about the effectiveness of debugging when random test cases are used

Automatically generated test cases are usually evaluated in terms of their fault revealing or coverage capability. Beside these two aspects, test cases are also the major source of information for fault localization and fixing. The impact of automatically generated test cases on the debugging activity, compared to the use of manually written test cases, has never been studied before. In this paper we report the results obtained from two controlled experiments with human subjects performing debugging tasks using automatically generated or manually written test cases. We investigate whether the features of the former type of test cases, which make them less readable and understandable (e.g., unclear test scenarios, meaningless identifiers), have an impact on accuracy and efficiency of debugging. The empirical study is aimed at investigating whether, despite the lack of readability in automatically generated test cases, subjects can still take advantage of them during debugging.
Failure of CRP decline within three days of hospitalization is associated with poor prognosis of Community-acquired Pneumonia

Abstract Background: C-reactive protein (CRP) is a well-known acute phase protein used to monitor the patient’s response during treatment in infectious diseases. Mortality from Community-acquired Pneumonia (CAP) remains high, particularly in hospitalized patients. Better risk prediction during hospitalization could improve management and ultimately reduce mortality levels. The aim of this study was to evaluate CRP on the 3rd day (CRP3) of hospitalization as a predictor for 30 days mortality. Methods: A retrospective multicentre cohort study of adult patients admitted with CAP at three Danish hospitals. Predictive associations of CRP3 (absolute levels and relative decline) and 30 days mortality were analysed using receiver operating characteristics and logistic regression. Results: Eight hundred and fourteen patients were included and 90 (11%) died within 30 days. The area under the curve for CRP3 level and decline for predicting 30 days mortality were 0.64 (0.57–0.70) and 0.71 (0.65–0.76). Risk of death was increased in patients with CRP3 level >75 mg/l (OR 2.44; 95%CI 1.36–4.37) and in patients with a CRP3 decline <50% (OR 4.25; 95%CI 2.30–7.83). In the multivariate analysis, the highest mortality risk was seen in patients who failed to decline by 50%, irrespective of the actual level of CRP (OR 7.8; 95%CI 3.2–19.3). Mortality risk increased significantly according to CRP decline for all strata of CURB-65 score. Conclusions: CRP responses day 3 is a valuable predictor of 30 days mortality in hospitalized CAP patients. Failure to decline in CRP was associated with a poor prognosis irrespective of the actual level of CRP or CURB-65.
Outcomes for Adolescents and young Adults with Autism Spectrum Disorder: General Social Functioning

Background: Earlier reports from different parts of the world reported fair to poor outcome of ASD in adolescence and young adult life. Method: Eighty children diagnosed as ASD from a public clinic and a day care centre for adolescent made the study sample. 59, (73%) of sample’s mothers were contacted by telephone 10-15 year after diagnoses to assess their children general social functioning and behaviour. Children were not seen or examined. Results: Sample mean age was 17.3 year–St Dev. 4.8 year, and mean age at diagnosis was 3.2 year. Male, female ratio was 4:1. Almost all attended day care programs for ASD and 10% are in regular school. A quarter of cases had friends and all were living with their families. None are married or hold a regular job. Researcher scored more small gains while mothers reported more substantial gains. Discussion and conclusion: 10-15 year outcome of children with ASD showed mixed results. Parents reported considerable benefits in social adjustment in half of the sample in comparison in quarter by independent researcher. Reasons for such difference were discussed. In future, we need to expand the follow up duration and use measurable parameters to assess benefits. Keywords: ASD; Adolescence; Young adult; Outcome; Social; Bahrain Introduction Today adolescents and young adult persons with Autism Spectrum Disorder (ASD) enjoy better opportunities than their predecessors. They have a better chance to be diagnosed early, receive special education, behavioural intervention, early school education and live with their families rather than institutions. The beginning of adulthood often involves significant changes in educational, vocational, housing, and interpersonal domains and the development of new roles and identity formation. Such changes are especially more stressful for adolescents with ASD and their families due to inherent difficulty of coping with change for persons with ASD. Additionally, the heterogeneity of ASD may make it challenging for families to develop clear expectations for the future. Finally, there are an increasing number of individuals with autism spectrum disorders entering adulthood; it is still unclear how the disorder impacts individuals later in the life course. Earlier reports from Europe, North America and Japan regarding adolescents with ASD revealed poor social adjustment for the majority [1-5]. Many remained in institutions for mentally ill people, lived in isolation, with very low work capacity skills level. Some studies identified good intellectual ability and the presence of speech at age 6 year
Beyond grand rounds: a comprehensive and sequential intervention to improve identification of delirium.

PURPOSE OF THE STUDY Delirium is a widespread concern for hospitalized seniors, yet is often unrecognized. A comprehensive and sequential intervention (CSI) aiming to effect change in clinician behavior by improving knowledge about delirium was tested. DESIGN AND METHODS A 2-day CSI program that consisted of progressive 4-part didactic series, including evidence-based reviews of delirium recognition, prevention, and management, interspersed with interactive small group sessions and practical case conferences was conceptualized in consultation with a leading expert on delirium. Pretest and posttest instruments were designed to test the attendees on their knowledge and confidence around delirium identification. RESULTS An average of 71 people attended each didactic session. Among all responses, 50 pretests and posttests were matched based on numeric coding (6 MD/DOs, 34 RNs, and 10 others). Mean pretest and posttest scores were 7.9 and 10.8 points, respectively (maximum: 17), showing a positive change in knowledge scores after the intervention (2.9 points, p < .001). Improvement in knowledge scores was higher in the cohort attending 2 or more lectures (3.8 points, p < .001) compared with those attending only 1 lecture (1.3 points, p < .12). Confidence in identifying patients with delirium increased by 28% (p < .001), and self-assessed capacity to correctly administer the Confusion Assessment Method increased by 36% (p < .001). IMPLICATIONS A novel CSI increased clinician knowledge about delirium identification and management and improved confidence and self-assessed capacity to identify delirium in the hospitalized elderly patients. This strategy, which incorporates multiple reinforcing modes of education, may ultimately be more effective in influencing clinician behavior when compared with traditional grand rounds.
Decision-making competence predicts domain-specific risk attitudes

Decision-making competence (DMC) reflects individual differences in rational responding across several classic behavioral decision-making tasks. Although it has been associated with real-world risk behavior, less is known about the degree to which DMC contributes to specific components of risk attitudes. Utilizing a psychological risk-return framework, we examined the associations between risk attitudes and DMC. Italian community residents (n = 804) completed an online DMC measure, using a subset of the original Adult-DMC battery. Participants also completed a self-reported risk attitude measure for three components of risk attitudes (risk-taking, risk perceptions, and expected benefits) across six risk domains. Overall, greater performance on the DMC component scales were inversely, albeit modestly, associated with risk-taking tendencies. Structural equation modeling results revealed that DMC was associated with lower perceived expected benefits for all domains. In contrast, its association with perceived risks was more domain-specific. These analyses also revealed stronger indirect effects for the DMC → expected benefits → risk-taking path than the DMC → perceived risk → risk-taking path, especially for behaviors that may be considered more maladaptive in nature. These results suggest that DMC performance differentially impacts specific components of risk attitudes, and may be more strongly related to the evaluation of expected value of a specific behavior.
Intrinsic knotting and linking of almost complete partite graphs

We classify graphs that are 0, 1, or 2 edges short of being complete partite graphs with respect to intrinsic linking and intrinsic knotting. In addition, we classify intrinsic knotting of graphs on 8 vertices. For graphs in these families, we verify a conjecture presented in Adams' "The Knot Book": If a vertex is removed from an intrinsically knotted graph, one obtains an intrinsically linked graph.
Neuroanatomic and magnetic resonance imaging references for normal development of cerebral sulci of laboratory primate, cynomolgus monkeys (Macaca fascicularis)

Cynomolgus monkey (Macaca fascicularis) is a popular laboratory primate belonging to Old World monkeys, which are the group most closely related to humans except for the apes. This paper summarizes a series of our studies regarding the development of cerebral sulci and gyri in this primate, and the stated possibility of evaluation of the sulcal development for assessing the developmental toxicity testing. The cerebrum of cynomolgus monkeys experienced a regular sequence of emergence of sulci and gyri on gross observation while such timetables corresponded to those obtained by magnetic resonance imaging (MRI) with a lag time of 10–30 days. When the timetables for the emergence of anatomically identical primary sulci and gyri were compared between cynomolgus monkeys and humans, their chronological sequences were comparable, while some sulci and gyri located on the phylogenetically newer cortical region in humans emerged earlier in monkeys. The present paper further indicates brief procedures for evaluating cerebral abnormalities and/or maturity using brain specimens without MRI measurements. The primary sulcal lengths measured by the ‘cotton thread’ method were a brief index of the degree of regional gyrification. As the development of a calcarine sulcus was closely correlated with morphological maturation of the lateral ventricle, which changed drastically during embryonic days (EDs) 90–100, the cerebral maturity on ED 100 could be evaluated by the infolding of that sulcus. Thus, the present paper provides gross anatomical and MRI references and brief procedures for investigating the normality of the development of cerebral sulci and gyri of laboratory primates, cynomolgus monkeys.
Detection of nucleophosmin and FMS-like tyrosine kinase-3 gene mutations in acute myeloid leukemia

Background and Objectives : Nucleophosmin gene mutations are frequently reported in acute myeloid leukemia (AML) patients with normal karyotype, which is also frequently associated with internal tandem duplication mutations in the FMS-like tyrosine kinase-3 gene. We sought to detect the nucleophosmin and FMS-like tyrosine kinase-3 (FLT3) internal tandem duplication (ITD) mutations among Iranian patients with AML and to assess the relationship between these mutations and the subtypes of the disease. Design and Setting : Cross-sectional study of patients referred during 2007 through 2009. Patients and Methods : Bone marrow and peripheral blood samples of 131 AML patients were randomly collected at the time of diagnosis and prior to treatment and the DNA extracted. After amplifying the nucleophosmin and FLT3 gene regions, positive cases were screened by conformation-sensitive gel electrophoresis and agarose gel electrophoresis techniques. Results : Of 131 patients, 23 (17.5%) (0.95% CI=0.107-0.244) had nucleophosmin gene mutations. The highest frequency of such mutations was found among the subtypes of M4 (30.4%), M3 (21.7%) and M5 (17.4%). There was a high frequency of these mutations in the M3 subtype as well as a high frequency of allele D in all subtypes. Also, 21 (16.0%) samples (0.95% CI=0.092-0.229) had FLT3/ITD mutation, of which 8 samples had mutant nucleophosmin (8 of 23, 35%), and another 13 samples had wild-type nucleophosmin gene (13 of 108, 12%). There was a high degree of association between the occurrence of nucleophosmin and FLT3/ITD mutations (P=.012). Conclusion : Our data showed a high frequency of NPM1 mutations in the monocytic subtypes of AML, as well as a high degree of association between the occurrence of NPM1 and FLT3/ITD mutations.
Utilization is virtually useless as a metric!

We have all been conditioned over the years to use utilization or %busy as the primary metric for capacity planning. Unfortunately, with increasing use of CPU virtualization and sophisticated CPU optimization techniques such as hyper-threading and power management the measurements we get from the systems are “virtually useless”. This paper will explain many of the ways in which the data we depend upon is distorted, and proposes that we turn to direct measurement of the fundamental alternatives, and express capacity in terms of headroom, in units of throughput within a response time limit.
Altered Sinonasal Ciliary Dynamics in Chronic Rhinosinusitis

Background Although multiple etiologies contribute to the development of rhinosinusitis, a common pathophysiological sequelae is ineffective sinonasal mucociliary clearance, resulting in stasis of sinonasal secretions, with subsequent infection, and persistent inflammation. The respiratory cilia beat continually at a basal rate, while during times of stress, such as exercise or infection, ciliary beat frequency (CBF) increases, accelerating mucus clearance. Previous investigations have led to conflicting results with some authors reporting decreased CBF while others have found normal values of CBF in patients with chronic rhinosinusitis (CRS). Additionally, these studies have only analyzed basal CBF. The goal of this study was to compare the basal as well as the stimulated sinonasal CBF in patients with CRS versus controls. Methods A dual temperature controlled perfusion chamber, differential interference contrast microscopy, and high-speed digital video were used to analyze both basal and adenosine triphosphate (100 μM)–stimulated CBF in human sinonasal mucosal explants. Results Although no difference in basal CBF was detected between control and CRS patients, a marked difference in stimulated CBF was noted. Exogenously applied adenosine triphosphate resulted in a 50–70% increase of CBF in control tissue with a minimally observed CBF increase in explants from CRS patients. Conclusion Dynamic regulation of respiratory ciliary activity is critical for the respiratory epithelium to adapt to varying environmental situations. Thus, diminished or absent adaptation could predispose the sinonasal cavity to accumulation of inhaled infectious and noxious particulate matter resulting in infection/inflammation. Our findings suggest that CRS patients have decreased sinonasal ciliary adaptation to environmental stimuli.