Miracle-dz/UniFAR-FTUs huggingface dataset:
Issues with Publishing Abstracts in English: Challenges for Portuguese Linguists' Authorial Voices

This paper assesses the impact of publishing abstracts in English in the Portuguese Linguistics Association (APL) Proceedings from 2001 to 2010. The study was carried out with a corpus of 137 abstracts, follows a Text Linguistics model inspired by the Interactionnisme Sociodiscoursif and links text features to the social practices and genre repertoires of this community. Quantitative data show signs of a “Portuguese identity” in authors’ voices such as personal forms, move signaling, long sentences, profuse embedding, heavy subjects, and variations in content selection, but also signs of standard academic guideline-indexed choices in impersonal forms, template sentences, coordinated constituents, nominalizations, and conventional text plans. Standard genre models and writing features from “core” academic communities coexist with alternative and traditional ways of writing and of disseminating knowledge, which is typical of a semiperipheral non-native English-speaking community torn between conflicting language and cultural paradigms. These contrasting tendencies are linked to identity changes within the community, as APL authors try to achieve international recognition by publishing abstracts in English as a Foreign Language. Since the APL research topic is the Portuguese language, the process mirrors the authors’ struggle between standard internationalization in English and individual stance in Portuguese.
Aggressive hydration with Lactated Ringer's solution as the prophylactic intervention for postendoscopic retrograde cholangiopancreatography pancreatitis: A randomized controlled double-blind clinical trial

Background: Pancreatitis is a serious complication of endoscopic retrograde cholangiopancreatography (ERCP) and may cause significant morbidity and even death. There is no effective prophylactic intervention for patients with average risk yet. This study aims to investigate preventive effect of aggressive hydration for post-ERCP pancreatitis. Materials and Methods: In a double-blind controlled setting, 150 patient were randomly assigned to receive either aggressive hydration with lactated Ringer's solution (3 mL/kg/h during ERCP, followed by a 20 mL/kg bolus and 3 mL/kg/h for 8 h after the procedure, n = 75) or standard amount of hydration (1.5 mL/kg/h during and for 8 h after ERCP, n = 75). Patients were observed for volume overload as well as pancreatic pain and serum levels of amylase at baseline and 2, 8, and 24 h after ERCP. Post-ERCP pancreatitis was defined as hyperamylasemia (level of amylase >300) and pancreatic pain during the 24 h follow-up. Hyperamylasemia and pancreatic pain were the secondary end points. Results: Mean age of the patients was 50.8 ± 13.5 years. Most of the patients were female (66%). Pancreatitis developed in 21 patients, including 22.7% of patients receiving standard hydration and 5.3% patients receiving aggressive hydration (P = 0.002). Hyperamylasemia was detected in 44.0% of patients receiving standard hydration and 22.7% of patients aggressive hydration (P = 0.006). The pancreatic pain was reported by 5.3% of patients receiving aggressive hydration and 37.3% of patients receiving standard hydration (P ≤ 0.005). Conclusion: Aggressive hydration with lactated Ringer's solution may effectively prevent post-ERCP pancreatitis as well as hyperamylasemia and pancreatic pain in patients with average risk.
The Importance of Discourse Markers in English Learning and Teaching

ion—With the wave of development of discourse analysis, more and more linguists and pedagogists begin to apply the research findings and results in this field to language learning and teaching and so far have provided a lot of help. However, whether it is also true for Chinese English learners in using these markers needs further proof. Thus this dissertation aims to investigate into the applicability of DM theory to Chinese teachers and learners in evaluation DMs and the problems they have in learning and using them. Through the analysis on both the qualitative and quantitative results, the research supports and proves the important position of dms in language learning and teaching. It also points out the problems faced by the learners and suggests some possible means for both teachers and students to solve the problems. Later it provides a possible way for the future teaching of dms, which in turn might provide a useful framework for other teaching methods. As a result of the theoretical analysis and the research, the paper concludes that dms do occupy a position in English learning and teaching. It is quite advisable and necessary to pay enough attention to them and try to apply and use them automatically, correctly and appropriately with the help of teachers. Also any over-emphasis on these dms should be avoided against a distraction from the subject matter and together with other methods to facilitate learning process and to bring out a most efficient and effective result in language
Detection and Identification of Anomalies in Wireless Mesh Networks Using Principal Component Analysis (PCA)

Anomaly detection is becoming a powerful and necessary component as wireless networks gain popularity. In this paper, we evaluate the efficacy of PCA based anomaly detection for wireless mesh networks. PCA was originally developed for wired networks. Our experiments show that it is possible to detect different types of anomalies in an interference prone wireless environment. However, the sensitivity of PCA to small changes in flows prompted us to develop an anomaly identification scheme which automatically identifies the flow(s) causing the detected anomaly and their contributions in terms of number of packets. Our results show that the identification scheme is able to differentiate false alarms from real anomalies and pinpoint the culprit(s) in case of a real fault or threat. The experiments were performed over an 8 node mesh testbed deployed in an urban street layout in Sydney, under different realistic traffic scenarios. Our identification scheme facilitates the use of PCA based method for real-time anomaly detection in wireless networks as it can filter the false alarms locally at the monitoring nodes without excessive computational overhead.
Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase from Maize: Molecular and Biochemical Characterization[OA]

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, an enzyme encoded by the gene IPK1, catalyzes the terminal step in the phytic acid biosynthetic pathway. We report here the isolation and characterization of IPK1 cDNA and genomic clones from maize (Zea mays). DNA Southern-blot analysis revealed that ZmIPK1 in the maize genome constitutes a small gene family with two members. Two nearly identical ZmIPK1 paralogs, designated as ZmIPK1A and ZmIPK1B, were identified. The transcripts of ZmIPK1A were detected in various maize tissues, including leaves, silks, immature ears, seeds at 12 d after pollination, midstage endosperm, and maturing embryos. However, the transcripts of ZmIPK1B were exclusively detected in roots. A variety of alternative splicing products of ZmIPK1A were discovered in maize leaves and seeds. These products are derived from alternative acceptor sites, alternative donor sites, and retained introns in the transcripts. Consequently, up to 50% of the ZmIPK1A transcripts in maize seeds and leaves have an interrupted open reading frame. In contrast, only one type of splicing product of ZmIPK1B was detected in roots. When expressed in Escherichia coli and subsequently purified, the ZmIPK1 enzyme catalyzes the conversion of myo-inositol 1,3,4,5,6-pentakisphosphate to phytic acid. In addition, it is also capable of catalyzing the phosphorylation of myo-inositol 1,4,6-trisphosphate, myo-inositol 1,4,5,6-tetrakisphosphate, and myo-inositol 3,4,5,6-tetrakisphosphate. Nuclear magnetic resonance spectroscopy analysis indicates that the phosphorylation product of myo-inositol 1,4,6-trisphosphate is inositol 1,2,4,6-tetrakisphosphate. Kinetic studies showed that the Km for ZmIPK1 using myo-inositol 1,3,4,5,6-pentakisphosphate as a substrate is 119 μm with a Vmax at 625 nmol/min/mg. These data describing the tissue-specific accumulation and alternative splicing of the transcripts from two nearly identical ZmIPK1 paralogs suggest that maize has a highly sophisticated regulatory mechanism controlling phytic acid biosynthesis.
Vasomotor symptoms, adoption of a low-fat dietary pattern, and risk of invasive breast cancer: a secondary analysis of the Women's Health Initiative randomized controlled dietary modification trial.

PURPOSE To assess whether the effect of a low-fat dietary pattern on breast cancer incidence varied by report of baseline vasomotor symptoms. METHODS Postmenopausal women age 50 to 79 years enrolled onto the Women's Health Initiative (WHI) Dietary Modification trial from 1993 to 1998 were randomly assigned to a low-fat dietary intervention (n = 19,541) or comparison (n = 29,294). Presence of vasomotor symptoms at baseline was ascertained from a 34-item self-report symptom inventory. Women were queried semi-annually for a new diagnosis of breast cancer. Each case report was verified by medical record and pathology report review by centrally trained WHI physician adjudicators. RESULTS Among participants who reported hot flashes (HFs) at baseline (n = 3,375), those assigned to the low-fat diet had a breast cancer rate of 0.27 compared with their counterparts in the control group who had a rate of 0.41 (hazard ratio [HR] = 0.65; 95% CI, 0.42 to 1.01). Among women reporting no HFs (n = 45,160), the breast cancer rate was 0.42 in those assigned to the low-fat diet compared with 0.46 in the control group (HR = 0.93; 95% CI, 0.84 to 1.03; P for interaction = .12 by HF status). Furthermore, the dietary benefits observed seemed to be specific to estrogen receptor (ER) -positive/progesterone receptor (PR) -positive tumors (ER positive/PR positive v other, P for risk = .03). Although women with and without HFs differed with regard to breast cancer risk factors, the effect of the diet intervention on breast cancer incidence by HF status was consistent across risk factor strata. CONCLUSION The results of this trial, which are hypothesis generating, suggest that HFs may identify a subgroup of postmenopausal women whose risk of invasive breast cancer might be reduced with the adoption of a low-fat eating pattern.
Performance evaluation of Attribute-Based Encryption: Toward data privacy in the IoT

With the ever increasing number of connected devices and the over abundance of data generated by these devices, data privacy has become a critical concern in the Internet of Things (IoT). One promising privacy-preservation approach is Attribute-Based Encryption (ABE), a public key encryption scheme that enables fine-grained access control, scalable key management and flexible data distribution. This paper presents an in-depth performance evaluation of ABE that focuses on execution time, data and network overhead, energy consumption, and CPU and memory usage. We evaluate two major types of ABE, Key-Policy Attribute-Based Encryption (KP-ABE) and Ciphertext-Policy Attribute-Based Encryption (CP-ABE), on different classes of mobile devices including a laptop and a smartphone. To the best of our knowledge, this is the first comprehensive study of ABE dedicated solely to its performance. Our results provide insights into important practical issues of ABE, including what computing resources ABE requires in heterogeneous environments, at what cost ABE offers benefits, and under what situations ABE is best suited for use in the IoT.
SMAC Advisor : A Decision-Support Tool on Coexistence of Genetically-Modified and Conventional Maize

This paper presents SMAC Advisor, a decision-support tool for the assessment of coexistence between genetically modified and conventional maize. The assessment is based on a qualitative multi-attribute DEXi model. This model was developed from two sources: (1) extensive simulations of gene flow due to cross-pollination, obtained by a simulator called MAPOD®, and (2) rules provided by experts in agronomy. SMAC Advisor provides a friendly “wizard” interface for its users: farmers, administrative workers and policy makers in agronomy.
Highly rarefied two-dimensional jet impingement on a flat plate

In this paper, we investigate highly rarefied jet gas flows out of a two-dimensional slit that impinges on a flat plate which is set vertically to the plume flow direction. The plate is assumed to be completely diffusive and the gaseous plume flow out of the slit is modeled with a Maxwellian distribution function which is characterized with known number density, nonzero exit velocity, and temperature. We present some analytical collisionless flow properties for a free plume and the impingement on the plate. The outcomes include simple results of the largest shear stress on the plate and the corresponding location. Numerical simulation results obtained with the direct simulation Monte Carlo method validate the analytical collisionless flow solutions.
Parity and secondary progression in multiple sclerosis

Background: Pregnancy has a well-documented effect on relapses in multiple sclerosis (MS), whereas little is known about the impact of pregnancy and childbirth on the risk of secondary progression. Objective: To investigate the association of parity and secondary progression in women with MS. Methods: The association of the number of births and secondary progression was studied in a hospital-based cohort of 277 women with MS. Data were analysed in a multivariable logistic regression model, with adjustment for possible confounders. Results: Parity was not independently associated with secondary progression, while the factors disease duration (OR per year increase: 1.05, 95% CI 1.03 to 1.09) and use of immunomodulatory treatments (OR 0.23, 95% CI 0.08 to 0.65) were independently associated with secondary progression. Conclusion: We found no evidence that parity influences the risk of secondary progression in MS. Further population-based studies on the association of pregnancy and childbirth on the long-term prognosis of MS are needed.
The Bayesian Basis of Common Sense Medical Diagnosis

In this paper, we show that the objections most frequently raised against the use of Bayesian statistics within the Al-in-medicine community do not seem to hold. In particular, we will show that the independence assumptions required to make Bayesian statistics computationally feasible are not nearly as damaging as has been claimed. We will also argue that Bayesian statistics is perfectly compatible with heuristic solutions to the multiple disease problem.
Detection of hepatitis C virus core protein in serum by atomic force microscopy combined with mass spectrometry

A method for detection and identification of core antigen of hepatitis C virus (HCVcoreAg)-containing particles in the serum was proposed, with due account taken of the interactions of proteotypic peptides with Na+, K+, and Cl− ions. The method is based on a combination of reversible biospecific atomic force microscopy (AFM)-fishing and mass spectrometry (MS). AFM-fishing enables concentration, detection, and counting of protein complexes captured on the AFM chip surface, with their subsequent MS identification. Biospecific AFM-fishing of HCVcoreAg-containing particles from serum samples was carried out using AFM chips with immobilized antibodies against HCVcoreAg (HCVcoreAgim). Formation of complexes between anti-HCVcoreAgim and HCVcoreAg-containing particles on the AFM chip surface during the fishing process was demonstrated. These complexes were registered and counted by AFM. Further MS analysis allowed reliable identification of HCVcoreAg within the complexes formed on the AFM chip surface. It was shown that MS data processing, with account taken of the interactions between HCVcoreAg peptides and Na+, K+ cations, and Cl− anions, allows an increase in the number of peptides identified.
Rumours and reputation: evaluating multi-dimensional trust within a decentralised reputation system

In this paper we develop a novel probabilistic model of computational trust that explicitly deals with correlated multi-dimensional contracts. Our starting point is to consider an agent attempting to estimate the utility of a contract, and we show that this leads to a model of computational trust whereby an agent must determine a vector of estimates that represent the probability that any dimension of the contract will be successfully fulfilled, and a covariance matrix that describes the uncertainty and correlations in these probabilities. We present a formalism based on the Dirichlet distribution that allows an agent to calculate these probabilities and correlations from their direct experience of contract outcomes, and we show that this leads to superior estimates compared to an alternative approach using multiple independent beta distributions. We then show how agents may use the sufficient statistics of this Dirichlet distribution to communicate and fuse reputation within a decentralised reputation system. Finally, we present a novel solution to the problem of rumour propagation within such systems. This solution uses the notion of private and shared information, and provides estimates consistent with a centralised reputation system, whilst maintaining the anonymity of the agents, and avoiding bias and overconfidence.
Antigenic structure of envelope glycoprotein E1 of hog cholera virus

Envelope glycoprotein E1 (gp51 to gp54) is the most antigenic protein of hog cholera virus or classical swine fever virus (CSFV). Four antigenic domains, A to D, have been mapped on E1 with a panel of monoclonal antibodies (MAbs) raised against CSFV strain Brescia. The boundaries of these domains have been established by extensive studies on binding of MAbs to transiently expressed deletion mutants of E1 (P. A. van Rijn, E. J. de Meijer, H. G. P. van Gennip, and R. J. M. Moormann, J. Gen. Virol. 74:2053-2060, 1993). In this study, we used neutralizing MAbs of domains A, B, and C to isolate MAb-resistant mutants (MAR mutants) of CSFV strain Brescia and Chinese vaccine strain ("C"). The E1 genes of MAR mutants were cloned in a eukaryotic expression vector, and the effects of MAR mutations on epitopes were studied with a panel of 19 MAbs by immunostaining of COS1 cells transiently expressing these mutant E1s. Except for the MAR mutation Cys-->Arg at position 792, which abolished binding of all MAbs of domains A and D, amino acid substitutions affected only MAbs belonging to the same domain as the MAb used to select the MAR mutant. However, a MAR mutation in a particular domain did not per se abolish binding of all MAbs recognizing that domain. Furthermore, MAR mutants possessed conservative as well as nonconservative amino acid substitutions. To investigate the significance of a secondary structure for the binding of MAbs, all cysteine residues in the N-terminal antigenic part of E1 were mutated to serine. We found that the cysteines at positions 693 and 737 were essential for binding by MAbs of domains B and C, whereas those at positions 792, 818, 828, and 856 appeared to be essential for the binding of most MAbs of domains A and D. These results fully comply with the previously proposed two-unit structure of the N-terminal half of E1. One unit consists of antigenic domains B and C, whereas the other unit consists of the highly conserved domain A and domain D. We conclude that the first six cysteines are critical for the correct folding of E1. A model of the antigenic structure of E1 is presented and discussed.
Is interactive open access publishing able to identify high-impact submissions? A study on the predictive validity of Atmospheric Chemistry and Physics by using percentile rank classes

In a comprehensive research project, we investigated the predictive validity of selection decisions and reviewers' ratings at the open access journal Atmospheric Chemistry and Physics (ACP). ACP is a high‐impact journal publishing papers on the Earth's atmosphere and the underlying chemical and physical processes. Scientific journals have to deal with the following question concerning the predictive validity: Are in fact the “best” scientific works selected from the manuscripts submitted? In this study we examined whether selecting the “best” manuscripts means selecting papers that after publication show top citation performance as compared to other papers in this research area. First, we appraised the citation impact of later published manuscripts based on the percentile citedness rank classes of the population distribution (scaling in a specific subfield). Second, we analyzed the association between the decisions (n = 677 accepted or rejected, but published elsewhere manuscripts) or ratings (reviewers' ratings for n = 315 manuscripts), respectively, and the citation impact classes of the manuscripts. The results confirm the predictive validity of the ACP peer review system. © 2011 Wiley Periodicals, Inc.
Milnacipran and venlafaxine at flexible doses (up to 200 mg/day) in the outpatient treatment of adults with moderate-to-severe major depressive disorder: a 24-week randomized, double-blind exploratory study

The objective of this exploratory, multicenter, randomized, double-blind study, was to evaluate the efficacy and safety/tolerability of milnacipran and venlafaxine administered at flexible doses (100, 150 or 200 mg/day, bid administration) for 24 weeks (including 4 weeks up titration period) in the outpatient treatment of adults presenting with a moderate or severe episode of major depressive disorder (MDD) without high suicidal risk (MINI-DSM IV-TR). Of the 195 patients included, 134 (68.7%) completed the study. At baseline the two groups were similar, except there was a higher proportion of patients whose episode was severe-DSM IV in the milnacipran group (63.3% versus 54.0% in the venlafaxine group). The initial MADRS score (mean 31.0) decreased progressively during the study, and this decrease was in the two treatment groups (n = 177: 90 milnacipran; 87 venlafaxine) at week 24 (observed case/OC, mean change −23.1 milnacipran; −22.4 venlafaxine). The rate of MADRS response (reduction ≥ 50%) at week 8 and week 24-last observation carried forward/LOCF was similar in the two groups (week 8: 64.4% milnacipran; 65.5% venlafaxine; week 24: 70% milnacipran; 77% venlafaxine), as was the rate of MADRS remission (score ≤ 10) (week 8: 42.2% milnacipran; 42.5% venlafaxine; week 24: 52.2% milnacipran; 62.1% venlafaxine). In both groups, the most common adverse events were: nausea, dizziness, headache, hyperhidrosis and, in males, genito-urinary problems. The overall safety/tolerability and efficacy profiles of milnacipran and venlafaxine administered at flexible dosages (up to 200 mg/day) were similar in the long term treatment of adults during episodes of MDD in an outpatient setting.