Miracle-dz/UniFAR-FTUs huggingface dataset:
In situ time-of-flight neutron imaging of NiO-YSZ anode support reduction under influence of stress

This article reports on in situ macroscopic scale imaging of NiO-YSZ (YSZ is yttria-stabilized zirconia) reduction under applied stress - a phase transition taking place in solid oxide electrochemical cells in a reducing atmosphere of a hydrogen/nitrogen mixture and at operation temperatures of up to 1073K. This process is critical for the performance and lifetime of the cells. Energy-resolved neutron imaging was applied to observe the phase transition directly with time and spatial resolution. Two different approaches are presented for using this imaging technique for the investigation of chemical and physical processes requiring controlled atmosphere and elevated temperature. The first type of measurement is based on alternating stages of short-term partial chemical reaction and longer neutron image acquisition, and the second type is a real in situ neutron imaging experiment. Results of applying energy-resolved neutron imaging with both approaches to the NiO-YSZ reduction investigation indicate enhancement of the reduction rate due to applied stress, which is consistent with the results of the authors' previous research.Results of the first in situ energy-resolved neutron imaging of NiO-YSZ (YSZ is yttria-stabilized zirconia) reduction under applied stress are presented. Neutron experiments were performed at the pulsed neutron source ISIS (UK) using a time-of-flight approach.
Carbon Nanotubes--the Route Toward Applications

Many potential applications have been proposed for carbon nanotubes, including conductive and high-strength composites; energy storage and energy conversion devices; sensors; field emission displays and radiation sources; hydrogen storage media; and nanometer-sized semiconductor devices, probes, and interconnects. Some of these applications are now realized in products. Others are demonstrated in early to advanced devices, and one, hydrogen storage, is clouded by controversy. Nanotube cost, polydispersity in nanotube type, and limitations in processing and assembly methods are important barriers for some applications of single-walled nanotubes.
Efferent control of temporal response properties of the Limulus lateral eye

The sensitivity of the Limulus lateral eye exhibits a pronounced circadian rhythm. At night a circadian oscillator in the brain activates efferent fibers in the optic nerve, inducing multiple changes in the physiological and anatomical characteristics of retinal cells. These changes increase the sensitivity of the retina by about five orders of magnitude. We investigated whether this increase in retinal sensitivity is accompanied by changes in the ability of the retina to process temporal information. We measured the frequency transfer characteristic (FTC) of single receptors (ommatidia) by recording the response of their optic nerve fibers to sinusoidally modulated light. We first measured the FTC in the less sensitive daytime state and then after converting the retina to the more sensitive nighttime state by electrical stimulation of the efferent fibers. The activation of these fibers shifted the peak of the FTC to lower frequencies and reduced the slope of the low-frequency limb. These changes reduce the eye's ability to detect rapid changes in light intensity but enhance its ability to detect dim flashes of light. Apparently Limulus sacrifices temporal resolution for increased visual sensitivity at night.
Use of Pharmacodynamic Parameters To Predict Efficacy of Combination Therapy by Using Fractional Inhibitory Concentration Kinetics

ABSTRACT Combination therapy with antimicrobial agents can be used against bacteria that have reduced susceptibilities to single agents. We studied various tobramycin and ceftazidime dosing regimens against four resistant Pseudomonas aeruginosa strains in an in vitro pharmacokinetic model to determine the usability of combination therapy for the treatment of infections due to resistant bacterial strains. For the selection of an optimal dosing regimen it is necessary to determine which pharmacodynamic parameter best predicts efficacy during combination therapy and to find a simple method for susceptibility testing. An easy-to-use, previously described E-test method was evaluated as a test for susceptibility to combination therapy. That test resulted in a MICcombi, which is the MIC of, for example, tobramycin in the presence of ceftazidime. By dividing the tobramycin and ceftazidime concentration by the MICcombi at each time point during the dosing interval, fractional inhibitory concentration (FIC) curves were constructed, and from these curves new pharmacodynamic parameters for combination therapy were calculated (i.e., AUCcombi, Cmax-combi,T>MIC-combi, andT>FICi, where AUCcombi,Cmax-combi,T>MIC-combi, andT>FICi are the area under the FICcombi curve, the peak concentration of FICcombi, the time that the concentration of the combination is above the MICcombi, and the time above the FIC index, respectively). By stepwise multilinear regression analysis, the pharmacodynamic parameter T>FICi proved to be the best predictor of therapeutic efficacy during combination therapy with tobramycin and ceftazidime (R2 = 0.6821; P < 0.01). We conclude that for combination therapy with tobramycin and ceftazidime the T>FICi is the parameter best predictive of efficacy and that the E-test for susceptibility testing of combination therapy gives promising results. These new pharmacodynamic parameters for combination therapy promise to provide better insight into the rationale behind combination therapy.
IMPEDANCE AND ADMITTANCE CONTROLLER FOR A MULTI-AXIS POWERED ANKLE-FOOT PROSTHESIS

This paper introduces a finite state machine to select between impedance and admittance control for a powered ankle-foot prosthesis controllable in both Dorsiflexion-Plantarflexion (DP) and Inversion-Eversion (IE). Strain gauges are installed on the prosthesis’ foot to measure the strain caused by ground reaction forces, which are correlated to the external torques in DP and IE. The external torques are used for the admittance and impedance controllers. Additionally, the finite state machine uses the strain gauges feedback to detect the heel-strike and switch to admittance control. The admittance control accepts torque feedback to generate motion, this way larger feedback torques effectively reduces the stiffness of the ankle. During push off, the finite state machine switches to impedance control, accepting motion feedback to generate the appropriated torques. The quasi-static stiffness of the prosthesis with impedance control was tested, showing a near linear relationship between the torque feedback gain and the stiffness of the ankle. The finite state machine and controllers were also evaluated using a custom-made circular treadmill and the results were compared to the results of position and passive controllers; showing that the impedance/admittance controller was capable of tracking the desired input trajectory while decreasing the required torque at the ankle joint.Copyright © 2014 by ASME
population growth, economic inequality, and homicide

Empirical research and theorizing on cross-national variations in homicide have been limited by an exclusive focus on the direct effects of national structural characteristics on the rates of homicide. This study is designed to extend this growing body of literature by advancing a conceptual model accounting for an important underlying feature of societies that indirectly elevates national homicide rates. Specifically, it is proposed that a high rate of population growth may have a direct role in bifurcating the distribution of national wealth. Population growth should therefore indirectly increase homicide rates through this mediating factor. This hypothesis is tested with data from 50 nations circa 1990. The data support the expected relationship, indicating (net of several controls) that rapid population growth is an underlying barrier to low homicide rates across nations. The main theoretical implication is that the often observed inverse relationship between level of development and rates of homicide appears to be indirectly driven by differential population dynamics.
Hamiltonian long–wave expansions for water waves over a rough bottom

This paper is a study of the problem of nonlinear wave motion of the free surface of a body of fluid with a periodically varying bottom. The object is to describe the character of wave propagation in a long–wave asymptotic regime, extending the results of R. Rosales & G. Papanicolaou (1983 Stud. Appl. Math. 68, 89–102) on periodic bottoms for two–dimensional flows.We take the point of view of perturbation of a Hamiltonian system dependent on a small scaling parameter, with the starting point being Zakharov's Hamiltonian (V. E. Zakharov 1968 J. Appl. Mech. Tech. Phys. 9, 1990–1994) for the Euler equations for water waves. We consider bottom topography which is periodic in horizontal variables on a short length–scale, with the amplitude of variation being of the same order as the fluid depth. The bottom may also exhibit slow variations at the same length–scale as, or longer than, the order of the wavelength of the surface waves. We do not take up the question of random bottom variations, a topic which is considered in Rosales & Papanicolaou (1983). In the two–dimensional case of waves in a channel, we give an alternate derivation of the effective Korteweg–de Vries (KdV) equation that is obtained in Rosales & Papanicolaou (1983). In addition, we obtain effective Boussinesq equations that describe the motion of bidirectional long waves, in cases in which the bottom possesses both short and long–scale variations. In certain cases we also obtain unidirectional equations that are similar to the KdV equation. In three dimensions we obtain effective three–dimensional long–wave equations in a Boussinesq scaling regime, and again in certain cases an effective Kadomtsev–Petviashvili (KP) system in the appropriate unidirectional limit. The computations for these results are performed in the framework of an asymptotic analysis of multiple–scale operators. In the present case this involves the Dirichlet–Neumann operator for the fluid domain which takes into account the variations in bottom topography as well as the deformations of the free surface from equilibrium.
Review: The central role of uncertainty reduction in determining behaviour.

In complex and stochastic environments the ability to cope with the unexpected is essential for survival. This paper describes a motivational framework founded on the need to reduce uncertainty. It is centred around a merging of classifier systems, taken from the field of artificial intelligence, with the information-primacy approach to animal motivation. It is proposed that in order to deal with uncertainty the animal constructs cognitive models of its environment that are composed of hierarchies of condition-action rules. There is parallel activation of several rules at any given time, and these rules compete to determine behaviour. The rules found to be the best predictors (and may in addition have resulted in reinforcement) gain strength, whilst the less successful rules lose strength over time. Unexpected events trigger the generation of families of new rules which are then subject to environmental selection. The efficient operation of the cognitive model requires the continual reduction of uncertainty, so that information-gathering behaviour forms a substratum upon which other, more obviously goal directed, behaviours occur. High need states can break into this ongoing behaviour and give it a special direction. The framework is related to the inherent variability of behaviour, the failure of certain reinforcement contingencies to control behaviour, and approach/avoidance behaviour towards novel stimuli.
A Test of the Conflict Linkage Model in the Context of Serial Arguments

This investigation tests Honeycutt's (2003) conflict linkage theory in the context of serial arguing. Reports on the characteristics of imagined interactions were obtained before, after, and between two episodes of the same serial argument. Analysis (N = 223) showed that imagined interactions affect the goals and tactics used in serial arguments. Imagined interactions have strong relationships among themselves, and this is a stronger effect than that of the arguments on the imagined interactions. Results support conflict linkage theory and add consistent support to the emerging empirical description of the internal dynamics of serial arguing processes.
The development of a questionnaire to assess the readiness of health care students for interprofessional learning (RIPLS)

Although shared learning activities are gradually being introduced to health care undergraduates, it has not been possible to measure the effects of educational interventions on students' attitudes. The main objective of this study was to develop a rating scale using items based on the desired outcomes of shared learning, to assess the `readiness' of health care students for shared learning activities.
Fertilization in vitro of rabbit eggs by epididymal spermatozoa capacitated in a chemically defined medium.

Newly ovulated eggs from mature does treated with FSH and hCG were inseminated in a defined medium with epididymal spermatozoa which were treated with the standard or HIS medium for 15 mm and preincubated for 10-10.5 h in a CO2 incubator. When spermatozoa in which viability after preincubation was maintained at levels of 50-60% were used, sperm penetration through the zona pellucida started 1-1.25 h after insemination and the transformation of sperm head into the male pronucleus occurred within 2 h in spermatozoa treated either with the standard or with HIS media. There was no significant difference between the overall penetration rates of the eggs 1-5.25 h after insemination with the spermatozoa treated with the standard (68.3%) or HIS media (59.1%). Most of the penetrated eggs developed to 2-or 4-cell and 8-16-cell stages 24 and 48 h after insemination, respectively. When four denuded eggs were inseminated with spermatozoa preincubared after treatment with the standard medium, all of them were penetrated with male pronucleus 5 h later. In some bucks, the proportion of motile spermatozoa after preincubation was greatly decreased (less than 5%), and such spermatozoa showed very low penetration ability.
In silico functional profiling of human disease‐associated and polymorphic amino acid substitutions

An important challenge in translational bioinformatics is to understand how genetic variation gives rise to molecular changes at the protein level that can precipitate both monogenic and complex disease. To this end, we compiled datasets of human disease‐associated amino acid substitutions (AAS) in the contexts of inherited monogenic disease, complex disease, functional polymorphisms with no known disease association, and somatic mutations in cancer, and compared them with respect to predicted functional sites in proteins. Using the sequence homology‐based tool SIFT to estimate the proportion of deleterious AAS in each dataset, only complex disease AAS were found to be indistinguishable from neutral polymorphic AAS. Investigation of monogenic disease AAS predicted to be nondeleterious by SIFT were characterized by a significant enrichment for inherited AAS within solvent accessible residues, regions of intrinsic protein disorder, and an association with the loss or gain of various posttranslational modifications. Sites of structural and/or functional interest were therefore surmised to constitute useful additional features with which to identify the molecular disruptions caused by deleterious AAS. A range of bioinformatic tools, designed to predict structural and functional sites in protein sequences, were then employed to demonstrate that intrinsic biases exist in terms of the distribution of different types of human AAS with respect to specific structural, functional and pathological features. Our Web tool, designed to potentiate the functional profiling of novel AAS, has been made available at http://profile.mutdb. org/. Hum Mutat 31:1–12, 2010. © 2010 Wiley‐Liss, Inc.
Soviet children of occupation in Austria: The historical, political and social background and its consequences

Soviet children of occupation were born between late 1945 and mid-1956 in Austria, some following voluntary sexual relations between local women and Red Army soldiers, others as a result of rape. They were considered by many to be ‘children of the enemy’ and encountered various forms of discrimination and stigmatisation. The children involved were largely a ‘fatherless’ group of war children. By the time of their births even fathers who wanted to stay in touch had generally either been sent home or transferred to another barracks in line with the Kremlin's view that intimate relations between Soviet soldiers and Austrians were politically and ideologically reprehensible. Even after the signing of the Austrian State Treaty and the end of the occupation in 1955, the political situation largely ruled out further contact. This situation was exacerbated by the onset of the Cold War. In many cases, the children of occupation were hemmed in by a wall of silence that in some cases persists to this day. This has led to widespread questions about personal identity and searches for their ‘roots’. Against this background, the article analyses the impact of the specific historical, political and social background of the lives of Soviet occupation children.
The Dynamic Relationship Between Physical Function and Cognition in Longitudinal Aging Cohorts

On average, older people remember less and walk more slowly than do younger persons. Some researchers argue that this is due in part to a common biologic process underlying age-related declines in both physical and cognitive functioning. Only recently have longitudinal data become available for analyzing this claim. We conducted a systematic review of English-language research published between 2000 and 2011 to evaluate the relations between rates of change in physical and cognitive functioning in older cohorts. Physical functioning was assessed using objective measures: walking speed, grip strength, chair rise time, flamingo stand time, and summary measures of physical functioning. Cognition was measured using mental state examinations, fluid cognition, and diagnosis of impairment. Results depended on measurement type: Change in grip strength was more strongly correlated with mental state, while change in walking speed was more strongly correlated with change in fluid cognition. Examining physical and cognitive functioning can help clinicians and researchers to better identify individuals and groups that are aging differently and at different rates. In future research, investigators should consider the importance of identifying different patterns and rates of decline, examine relations between more diverse types of measures, and analyze the order in which age-related declines occur.
Uneasy Coalition: The Entente Experience in World War I

Suggestions for a Typology of Wartime Coalitions Pre-War Planning Between Allies and Potential Allies Particularistic Interests in the Coalition Human Relations Soldier-Soldier Relationship Relationships Between Soldiers and Politicians Coordination Conferences and Coordination Bodies General Reserve and Unified Command Amalgamation of Forces Logistics and War Finances Alliance on the "Peacepath" Conclusions and Lessons General Index
Explanations given by child pornography offenders for their crimes

Abstract The explanations given by child pornography offenders for their crimes were explored in two samples, one interviewed by the police as part of a criminal investigation and the second assessed by clinicians following a child pornography conviction. There were many similarities across the two samples with regard to demographic characteristics, criminal history and explanations. Many offenders in both samples admitted possession of child pornography, a majority admitted they deliberately accessed child pornography, and substantial minorities acknowledged their sexual interest in child pornography and/or children. Similar proportions claimed curiosity or accidental access. Relatively few offenders reported internet addiction, child pornography as a substitute for contact offending or indiscriminate sexual interests. There was evidence to suggest that the recently arrested offenders were more sexually deviant, as they were more likely to have images of boys, larger collections, images depicting sexual violence or other paraphilic content and more involvement in online trading and communication.
Selection for mitonuclear co-adaptation could favour the evolution of two sexes

Mitochondria are descended from free-living bacteria that were engulfed by another cell between one and a half to two billion years ago. A redistribution of DNA led to most genetic information being lost or transferred to a large central genome in the nucleus, leaving a residual genome in each mitochondrion. Oxidative phosphorylation, the most critical function of mitochondria, depends on the functional compatibility of proteins encoded by both the nucleus and mitochondria. We investigate whether selection for adaptation between the nuclear and mitochondrial genomes (mitonuclear co-adaptation) could, in principle, have promoted uniparental inheritance of mitochondria and thereby the evolution of two mating types or sexes. Using a mathematical model, we explore the importance of the radical differences in ploidy levels, sexual and asexual modes of inheritance, and mutation rates of the nucleus and mitochondria. We show that the major features of mitochondrial inheritance, notably uniparental inheritance and bottlenecking, enhance the co-adaptation of mitochondrial and nuclear genes and therefore improve fitness. We conclude that, under a wide range of conditions, selection for mitonuclear co-adaptation favours the evolution of two distinct mating types or sexes in sexual species.
Calcification of the cold-water coral Lophelia pertusa, under ambient and reduced pH

Abstract. The cold-water coral Lophelia pertusa is one of the few species able to build reef-like structures and a 3-dimensional coral framework in the deep oceans. Furthermore, deep cold-water coral bioherms may be among the first marine ecosystems to be affected by ocean acidification. Colonies of L. pertusa were collected during a cruise in 2006 to cold-water coral bioherms of the Mingulay reef complex (Hebrides, North Atlantic). Shortly after sample collection onboard these corals were labelled with calcium-45. The same experimental approach was used to assess calcification rates and how those changed due to reduced pH during a cruise to the Skagerrak (North Sea) in 2007. The highest calcification rates were found in youngest polyps with up to 1% d−1 new skeletal growth and average rates of 0.11±0.02% d−1±S.E. ). Lowering pH by 0.15 and 0.3 units relative to the ambient level resulted in calcification being reduced by 30 and 56%. Lower pH reduced calcification more in fast growing, young polyps (59% reduction) than in older polyps (40% reduction). Thus skeletal growth of young and fast calcifying corallites suffered more from ocean acidification. Nevertheless, L. pertusa exhibited positive net calcification (as measured by 45Ca incorporation) even at an aragonite saturation state (Ωa) below 1.