Miracle-dz/UniFAR-FTUs huggingface dataset:
Making connections: a dialogue about learning and teaching in a tertiary enabling program

This paper concerns the experiences and effects of a tertiary entrance program from two perspectives: that of a former student now engaged in her Honours program and of her enabling lecturer. The main aim of the paper is to present a literature review of published studies about mature women’s engagement with tertiary study at the entry level. The authors utilise their enabling education biographies to connect the review of literature to lived experiences. The study asks: how far does the literature cover their experiences and what gaps, if any, are there? The first section briefly outlines the approach taken in the paper. In the second section the enabling experience is discussed in three parts: motivations to enter, the first assignment and course encounters. The third section examines the wider effects of participation in enabling on the self, family and friends. The paper bears out the findings of recent literature that highlighted the powerful transformative effects of such programs in all spheres of the students’ lives and the importance of making connections in enabling programs. It suggests that more research needs to be carried out in a number of areas, especially gender, race and class.
Uptake of Best Arthritis Practice in Primary Care — No Quick Fixes

Arthritis is one of the most common chronic conditions and is a leading cause of pain, physical disability, and use of healthcare resources1. The Canadian Community Health Survey conducted in 2000 demonstrated that arthritis and other rheumatic conditions affect nearly 4 million Canadians aged 15 years and older2. By 2026, it has been estimated that this figure will rise to over 6 million Canadians. In the UK the National Institute for Health and Clinical Excellence developed recommendations for the management of rheumatoid arthritis3 and osteoarthritis (OA)4,5. For primary care the first message that emerges from the reviews and guidelines, particularly for OA, is that there is a range of simple interventions for which there is evidence of efficacy. By contrast, evidence that these same interventions are being systematically and widely put into practice, and evidence about how to do this, is singularly lacking6,7,8. There is increasing recognition that implementation of change for the better management of arthritis is very different from simply disseminating information9,10. Despite many published treatment guidelines there is often a gap between the care that is recommended and the care that such patients receive11; therefore numerous studies have demonstrated the need for improved arthritis management within primary care12,13. Unfortunately, their abundance can often … Address correspondence to K.S. Dziedzic. E-mail: k.s. dziedzic{at}keele.ac. uk
The contribution of parents and siblings to antisocial and depressive behavior in adolescents: A double jeopardy coercion model

A dual coercion model of family processes associated with the development of antisocial and depressive behavior during adolescence was assessed, using an at-risk sample of families and children. Consistent with the model, involvement in family coercion during childhood and adolescence increased both boys' and girls' risk for antisocial behavior in adolescence and girls' risk for depressive behavior. Coercive family processes served as a link between older and younger siblings' antisocial behavior. Childhood exposure to maternal depression predicted boys' and girls' depressive behavior 10 years later, but this association was not mediated by coercion. The data suggest that family risk factors and processes for antisocial development are similar for boys and girls but pathways to depression may be gender specific.
Snow trends in Northern Spain: analysis and simulation with statistical downscaling methods

In this study we analyze and simulate (with statistical downscaling techniques) the snow trends observed in the Northern Iberian Peninsula using daily snow occurrence (DSO) data from a network of 33 stations ranging from 60 to 1350 m. We first analyze the annual snow frequency measured as the annual number of snow days (NSD), obtaining a significant decreasing trend since the mid‐seventies with a NSD reduction of about 50%; moreover, this magnitude is similar for low and high stations and for winter and spring separately. Then, we analyze the existing correlations with mean temperature and precipitation occurrence obtaining different relationships depending on the season and elevation. Finally, we simulate the observed trends using the connection of DSO with large‐scale fields simulated by a General Circulation Model; for this purpose we apply an analog‐based statistical downscaling method to obtain an estimation of DSO, working in perfect prognosis conditions using reanalysis data. On the one hand, the downscaling method is able to estimate/predict the DSO with typical values of hit and false alarm rates around 60% and 2%, respectively. On the other hand, the annual frequency obtained by averaging the DSO estimations reproduces very well both the observed trends and the high inter‐annual variability. These promising results open the possibility to future research in seasonal or climate change projections of snow frequency. Copyright © 2009 Royal Meteorological Society
Psychological health in patients with amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with no known effective treatment or cure. Clinicians often expect that ALS patients will experience depression following the diagnosis because ALS is a terminal disease. The objective of the current study was to examine the evidence from the literature on psychological health in ALS patients in order to determine the prevalence and severity of depression in this population. Twenty‐eight studies of ALS patients, conducted over the past 20 years, were reviewed and evaluated. The cumulative evidence suggests that clinically significant depression is neither as prevalent nor as severe as might be expected. Methodological limitations that are inherent to the measurement of depression in ALS, including the lack of appropriate instruments, small sample sizes, and reliance on cross‐sectional data, have contributed to the wide range of reported results. We conclude that ALS patients are more likely to present with hopelessness and end‐of‐life concerns than clinically significant depression. It is important to assess a broad range of potential psychological distress early in the course of ALS, rather than focus specifically on depression, because the manner in which patients cope with their disease can affect their longevity.
Mill's Progressive Principles

TABLE OF CONTENTS Preface A Note on Mill's Texts 1. Mill's Radical Background 2. Varieties of Motivation 3. Perfectionism about Happiness and Higher Pleasures 4. Ambivalence about Duty 5. The Justification of Utilitarianism 6. Liberal Preliminaries 7. Freedom of Expression in a Liberal Context 8. Liberal Principles Refined 9. Liberalism, Utilitarianism, and Rights 10. Liberal Democracy 11. Sexual Equality Epilogue Bibliography Index
Fully automatic liver segmentation for contrast-enhanced CT images

The need for fast and precise segmentation has increased recently due to the spread of systems for computer aided diagnosis and therapy planning. The manual segmentation of the liver is very time con- suming, so it is desired to develop a method that can precisely segment the liver without any human interaction. In this paper we propose a fully automatic method for liver segmentation on contrast-enhanced (por- tal venous) CT images. Our method is essentially an advanced region- growing the result of that is improved by various pre- and post-processing steps, like intensity based ROI detection, separation of liver and heart, additional segmentation at the right lung lobe, vessel (IVC) removal, and cavity filling. According to our experiments the method can eciently segment the liver parenchyma in many cases, however, in some cases the result may exclude very large lesions.
The pyruvate dehydrogenase complex as a therapeutic target for age‐related diseases

Considerable research has been conducted on mitochondrial biology as it pertains to aging. However, relatively little attention has been accorded the pyruvate dehydrogenase complex (PDC) relative to how we grow old and acquire age‐related diseases. The purpose of this review is threefold: first, to describe the physiological chemistry of the PDC and define its place in normal cellular bioenergetics; second, to compare and contrast the pathogenesis and clinical features of congenital PDC deficiency with discrete examples of age‐associated dysfunction of the complex; and third, to summarize recent findings in Caenorhabditis elegans that shed additional new light on the significance of the PDC to the aging process.
Antibiotic susceptibility and β‐lactamase production in clinical isolates of Enterobacter spp.

The in vitro susceptibility of 237 clinical isolates of Enterobacter spp. (E. aerogenes, E. agglomerans and E. cloacae; 41, 64 and 132 respectively) to 16 different antibiotics is described. Four quinolones (ciprofloxacin, lomefloxacin, norfloxacin and ofloxacin), two new cephalosporins (cefpirome and cefepime) and imipenem, all showed high activity against the three Enterobacter species tested (MIC50≤ 0.125 mg/l, MIC90≤ 0.5 mg/l). Also the aminoglycosides gentamicin and tobramycin were highly active antibiotics (MIC50≤ 0.5 mg/l, MIC90≤ 1.0 mg/l). The susceptibility of β‐lactam‐antibiotics to β‐lactamase produced by Enterobacter spp. was evaluated, and imipenem and cefepime were found to be most stable. Different methods for detection of inducible β‐lactamases were used, the agar dilution method being more sensitive than the double‐disc diffusion test. Elevated β‐lactamase production was detected, via induction, in 83% of E. aerogenes strains and 70% of E. cloacae strains, with cefamandole used as the substrate and cefoxitin as the inducer. Constitutive, high level enzyme production was detected in 7 and 13% respectively of the E. aerogenes and the E. cloacae strains. In all the strains of E. agglomerans, 10% of E. aerogenes and 13% of E. cloacae, no β‐lactamases could be detected with the methods studied.
Rethinking the Gains from Immigration: Theory and Evidence from the U.S.

Recent influential empirical work has emphasized the negative impact immigrants have on the wages of U.S.-born workers, arguing that immigration harms less educated American workers in particular and all U.S.-born workers in general. Because U.S. and foreign born workers belong to different skill groups that are imperfectly substitutable, one needs to articulate a production function that aggregates different types of labor (and accounts for complementarity and substitution effects) in order to calculate the various effects of immigrant labor on U.S.-born labor. We introduce such a production function, making the crucial assumption that U.S. and foreign-born workers with similar education and experience levels may nevertheless be imperfectly substitutable, and allowing for endogenous capital accumulation. This function successfully accounts for the negative impact of the relative skill levels of immigrants on the relative wages of U.S. workers. However, contrary to the findings of previous literature, overall immigration generates a large positive effect on the average wages of U.S.-born workers. We show evidence of this positive effect by estimating the impact of immigration on both average wages and housing values across U.S. metropolitan areas (1970-2000). We also reproduce this positive effect by simulating the behavior of average wages and housing prices in an open city-economy, with optimizing U.S.-born agents who respond to an inflow of foreign-born workers of the size and composition comparable to the immigration of the 1990s.
Serodiagnosis of Toxocariasis by ELISA Using Crude Antigen of Toxocara canis Larvae

Toxocariasis is a worldwide zoonosis caused by larvae of ascarid nematodes of dogs or cats, Toxocara canis or T. cati. Diagnosis of human toxocariasis currently relies on serology that uses T. canis excretory-secretory antigen to detect specific IgG antibodies by ELISA. We investigated the serodiagnostic efficacy of ELISA using crude antigen of T. canis larvae (TCLA). Serum specimens of 64 clinically confirmed toxocariasis, 115 healthy controls, and 119 other tissue-invading helminthiases were screened by ELISA using TCLA. The ELISA using TCLA showed 92.2% (59/64 patient samples) sensitivity and 86.6% (103/119) specificity. Its positive diagnostic predictivity was 78.7% and negative predictivity was 97.8%. No serum of healthy controls reacted but that of anisakiasis (45.5%), gnathostomiasis (19.2%), clonorchiasis (15.8%), sparganosis (11.1%), and cysticercosis (6.3%) cross-reacted. Immunoblot analysis on TCLA recognized antigenic proteins of 28- and 30-kDa bands in their dominant protein quantity and strong blotting reactivity. The present results indicate that the ELISA using our TCLA antigen is acceptable by the sensitivity and specificity for serodiagnosis of human toxocariasis. ELISA with TCLA is recommended to make differential diagnosis for patients with any sign of organ infiltration and eosinophilia.
An extended reinforcement learning model of basal ganglia to understand the contributions of serotonin and dopamine in risk-based decision making, reward prediction, and punishment learning

Although empirical and neural studies show that serotonin (5HT) plays many functional roles in the brain, prior computational models mostly focus on its role in behavioral inhibition. In this study, we present a model of risk based decision making in a modified Reinforcement Learning (RL)-framework. The model depicts the roles of dopamine (DA) and serotonin (5HT) in Basal Ganglia (BG). In this model, the DA signal is represented by the temporal difference error (δ), while the 5HT signal is represented by a parameter (α) that controls risk prediction error. This formulation that accommodates both 5HT and DA reconciles some of the diverse roles of 5HT particularly in connection with the BG system. We apply the model to different experimental paradigms used to study the role of 5HT: (1) Risk-sensitive decision making, where 5HT controls risk assessment, (2) Temporal reward prediction, where 5HT controls time-scale of reward prediction, and (3) Reward/Punishment sensitivity, in which the punishment prediction error depends on 5HT levels. Thus the proposed integrated RL model reconciles several existing theories of 5HT and DA in the BG.
Identification of Non-dot/icm Suppressors of the Legionella pneumophila ΔdotL Lethality Phenotype

ABSTRACT Legionella pneumophila, a causative agent of bacterial pneumonia, survives inside phagocytic cells by avoiding rapid targeting to the lysosome. This bacterium utilizes a type IVB secretion system, encoded by the dot/icm genes, to replicate inside host cells. DotL, a critical component of the Dot/Icm secretion apparatus, functions as the type IV coupling protein. In contrast to most dot/icm genes, which are dispensable for growth on bacteriological media, dotL is required for the viability of wild-type L. pneumophila. Previously we reported that ΔdotL lethality could be suppressed by inactivation of the Dot/Icm complex via mutations in other dot/icm genes. Here we report the isolation of non-dot/icm suppressors of this phenotype. These ΔdotL suppressors include insertions that disrupt the function of the L. pneumophila homologs of cpxR, djlA, lysS, and two novel open reading frames, lpg0742 and lpg1594, that we have named ldsA and ldsB for lethality of ΔdotL suppressor. In addition to suppressing ΔdotL lethality, inactivation of these genes in a wild-type strain background causes a range of defects in L. pneumophila virulence traits, including intracellular growth, implicating these factors in the proper function of the Dot/Icm complex. Consistent with previous data showing a role for the cpx system in regulating expression of several dot/icm genes, the cpxR insertion mutant produced decreased levels of three Dot/Icm proteins, DotA, IcmV, and IcmW. The remaining four suppressors did not affect the steady-state levels of any Dot/Icm protein and are likely to represent the first identified factors necessary for assembly and/or activation of the Dot/Icm secretion complex.
Effects of hypogonadism and testosterone administration on depression indices in HIV-infected men.

Hypogonadism is prevalent among human immunodeficiency virus-infected men, in whom significantly reduced quality of life and mood disturbances have been reported. Previous studies have not investigated the relationship between depression score and gonadal function among such patients. We first compared depression scores in hypogonadal (n = 52) and eugonadal (n = 10) patients with acquired immunodeficiency syndrome (AIDS) wasting, matched for weight and disease status, and then investigated the effects of testosterone administration on depression score in a randomized, double-blind, placebo-controlled study among the group of hypogonadal men with AIDS wasting. The primary end point in all comparisons was the Beck Depression Inventory. Hypogonadal patients demonstrated significantly increased scores on the Beck inventory compared with eugonadal-, age-, weight-, and disease status-matched subjects (15.5+/-1.1 vs. 10.6+/-1.4 mean +/- SEM, P = 0.02). Among the combined hypogonadal and eugonadal subjects, a significant inverse correlation was seen between the Beck score and both free (r = 0.41, P<0.01) and total serum testosterone levels (r = -0.43, P<0.001). The relationship between the Beck score and testosterone levels remained highly significant, controlling for weight, viral load, CD4 count, and antidepressant use (P<0.01 for free testosterone, P<0.001 for total testosterone). Furthermore, when subjects were divided into two groups, based on a Beck score greater than 18 or less than or equal to 18, serum total and free testosterone levels were significantly lower in the subjects with a Beck score greater than 18, whereas there were no differences in weight, viral load, CD4 count, or Karnofsky status. End of study data were available in 39 patients who completed the randomized, placebo-controlled study. Beck score decreased significantly only in the subjects receiving testosterone (-5.8+/-1.3, P< 0.001), but not in subjects randomized to placebo (-2.7+/-1.3, P> 0.05). In a regression analysis, the change in Beck score was related significantly to change in weight (P<0.01). These data demonstrate increased depression score in association with hypogonadism in men with AIDS wasting, independent of weight, virologic status, and other disease factors. In such patients, administration of testosterone results in a significant improvement in depression inventory score. This effect may be a direct effect of testosterone or related to positive effects of testosterone on weight and/or other anthropometric indices. Additional studies are needed to assess the effects of testosterone on clinical depression indices in human immunodeficiency virus-infected patients.
Decomposition Based Algorithm for State Prediction in Large Scale Distributed Systems

Prediction represents an important component of resource management, providing information about the future state, utilization and availability of resources. We propose a new prediction algorithm inspired from the decomposition of a complex wave into simpler waves with fixed frequencies (similar to Fourier decomposition). The partial results obtained from this decomposition stage are combined using approaches inspired from artificial intelligence models. The experimental results for different system parameters, used in Alice experiment, highlight the great improvement, discussed in terms of error reduction, offered by this new prediction algorithm. The tests were made using real-time monitoring data provided by a system monitoring tool, in the case of one-step and multi-step ahead prediction. The prediction's results can be used by the resource management systems in order to improve the scheduling decisions, assuring the load balancing and optimizing the resource utilization.
Morphological and functional evaluation of an animal model for the retinal degeneration induced by N-methyl-N-nitrosourea

The retinal degeneration (RD) is a general cause of blindness. To study its pathophysiology and evaluate the effects of new therapeutic agents before clinical trials, it is essential to establish reliable and stable animal models. This study evaluated a RD animal model in which blindness was induced by N-methyl-N-nitrosourea (MNU), a potent retinotoxin leading to apoptosis of photoreceptors. MNU was applied to the Sprague-Dawley rats by a single intraperitoneal injection in different doses (40, 50, and 60 mg/kg). The retinal functions were examined at 1 week after MNU injection by electroretinogram (ERG). Afterwards, each retina was examined by hematoxylin and eosin stain and immunohistochemistry with anti-glial fibrillary acidic protein antibody. Upon MNU injection of 40, 50 and 60 mg/kg, the ERG amplitude of a-waves showed significant reductions of 7, 26, and 44%, respectively, when compared to that of normal a-waves. The b-wave amplitudes were about 89, 65, and 58% of normal b-waves in the response to scotopic light stimulus. At 1 week, 2 weeks, and 4 weeks after MNU injection (50 mg/kg), all scotopic ERG components decreased progressively. In addition, degeneration of retinal neurons was observed in a time- and dose-dependent manner after MNU injection. Taken together, functional reduction following RD induced by MNU correlates with morphological changes. Thus, this RD rat model may be a useful model to study its pathophysiology and to evaluate the effects of new therapeutic agents before clinical trials.
Le codage des mouvements volontaires : référentiel et coordination : enregistrements unitaires dans le cortex prémoteur et moteur du singe

To test the functional implications of gaze signals that we previously reported in the dorsal premotor cortex (PMd), we trained two rhesus monkeys to point to visual targets presented on a touch screen while controlling their gaze orientation. Each monkey had to perform four different tasks. To initiate a trial, the monkey had to put his hand on a starting position at the center of the touch screen and fixate a fixation point. In one task, the animal had to make a reaching movement to a peripheral target randomly presented at one of eight possible locations on a circle while maintaining fixation at the center of this virtual circle (central fixation + reaching). In the second task, the monkey maintained fixation at the location of the upcoming peripheral target and, later, reached to that location. After a delay, the target was turned on and the monkey made a reaching arm movement (target fixation + reaching). In the third task, the monkey made a saccade to the target without any arm movement (saccade). Finally, in the fourth task, the monkey first made a saccade to the target, then reached to it after a delay (saccade + reaching). This design allowed us to examine the contribution of the oculomotor context to arm-related neuronal activity in PMd. We analyzed the effects of the task type on neuronal activity and found that many cells showed a task effect during the signal (26/60; 43%), set (16/49; 33%) and/or movement (15/54; 28%) epochs, depending on the oculomotor history. These findings, together with previously published data, suggest that PMd codes limb-movement direction in a gaze-dependent manner and may, thus, play an important role in the brain mechanisms of eye-hand coordination during visually guided reaching.