Miracle-dz/UniFAR-FTUs huggingface dataset:
Reinforcing Effects of σ-Receptor Agonists in Rats Trained to Self-Administer Cocaine

σ-Receptor (σR) antagonists have been reported to block certain effects of psychostimulant drugs. The present study examined the effects of σR ligands in rats trained to self-administer cocaine (0.032–1.0 mg/kg/inj i.v.) under fixed-ratio 5-response schedules of reinforcement. Maximal rates of responding were maintained by 0.32 mg/kg/inj cocaine, or by the σR agonists, 1,3-di-(2-tolyl)guanidine (DTG; 1.0 mg/kg/inj) or 2-(4-morpholinethyl) 1-phenylcyclohexane-1-carboxylate hydrochloride (PRE-084; 0.32 mg/kg/inj), when substituted for cocaine. Lower response rates were maintained at higher and lower doses of the compounds. No dose of the σR antagonists [N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine (BD 1008), N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine (BD 1047), N-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine (BD 1063)] maintained responding appreciably above levels obtained when responding had no consequences. Presession treatment with σR agonists dose-dependently shifted the cocaine self-administration dose-effect curve leftward. The dopamine-uptake inhibitor, (−)-2β-carbomethoxy-3β-(4-fluorophenyl)tropane (WIN 35,428), dose-dependently shifted the DTG and PRE-084 self-administration dose-effect curves leftward. Treatment with the σR antagonists dose-dependently decreased response rates maintained by DTG or PRE-084, but did not affect cocaine self-administration. Response rates maintained by maximally effective DTG or PRE-084 doses were decreased by σR antagonists at lower doses than those that decreased response rates maintained by food reinforcement. Although σR antagonists block some cocaine-induced effects, the lack of effect on cocaine self-administration suggests that the primary reinforcing effects of cocaine do not involve direct effects at σRs. However, the self-administration of σR agonists in cocaine-trained subjects, facilitation of cocaine self-administration by σR-agonist pretreatment, and the facilitation of σR-agonist self-administration by WIN 35,428, together suggest enhanced abuse-related effects resulting from concomitant dopaminergically mediated actions and σR-mediated actions of the drugs.
THE PSYCHOLOGY OF LEARNING

In recent years, I am pleased to see a rising interest in the 'human side' of Lean and Continuous Improvement. True more and more organizations are seeing people as their most valuable assets, and are beginning to treat them as such. But more interestingly, I am seeing more articles, workshops, presentations and the like addressing the personal aspect of change. As a person with a background in Organizational and Behavioral Science, this truly pleases me. People are better understanding 'what makes people tick', so to speak.
Influence of condensate evaporation on water vapor and its stable isotopes in a GCM

The direct effect of condensate evaporation on atmospheric water vapor and its isotopic composition is assessed in a climate model. The model contains two parallel hydrologic cycles, an active one which influences the model physics and dynamics and a passive one which does not. Two model simulations are performed, one in which passive cloud and precipitation can evaporate and one in which they cannot. The active hydrologic cycles, and thus the simulated circulations and temperatures, are identical in both simulations. Eliminating passive condensate evaporation reduces the specific humidity in the passive cycle by around 5%; this reduction varies from a few percent to 25% of the control value, depending on location. Zonal mean water vapor in the lower and middle troposphere is enriched in HDO relative to the control case, and is depleted in the upper troposphere.
Low Dose Intrarenal Infusions of PGE2, PGI2/ and 6‐Keto‐PGEx Vasodilate the in Vivo Rat Kidney

The renal vascular effects of prostaglandin Ej (PGEj), 6-keto-PCE, and PGL were investigated in indomethacin-pretreated rats. These prostanoids were infused directly into the left renal artery at rates ranging from 0.01 to 1.0 /ig/min, while renal blood flow and mean arterial blood pressure were constantly monitored. PGE, 6-keto-PCEi, and PGIj produced reductions in mean arterial blood pressure with threshold doses of 1.0, 0.3, and 0.03;ig/min (P < 0.01), respectively, and maximal vasodepressor responses of 18.9 % 4.3, 37.0 % 7.8, and 58.7 % 8.2 mm Hg (P < 0.01), respectively. In addition, all three prostanoids caused a dose-related reduction in renal vascular resistance with a threshold dose of 0.01 /xg/min (P < 0.05). The maximal reductions in renal vascular resistance were 2.59 % 0.52, 4.41 % 1.20, and 5.29 % 1.06 mm Hg/(ml per min) for PGEj, 6-keto- PGEi, and PGI2 (P < 0.01), respectively. Whereas PGE2 and 6-keto-PGEi produced dose-dependent increases in renal blood flow (maximal increases of 1.5 % 0.3 and 1.0 % 0.3 ml/min, respectively (P < 0.01), PGI2 nonsignificantly increased renal blood flow at low doses and decreased renal blood flow at higher infusion rates (P < 0.01). These data indicate that the in vivo rat kidney, similar to the kidneys of other species, is vasodilated by low doses of PGE2, PGI2, and 6-keto-PGEi.
Stable lattice Boltzmann model for Maxwell equations in media.

The present work shows a method for stable simulations via the lattice Boltzmann (LB) model for electromagnetic waves (EM) transiting homogeneous media. LB models for such media were already presented in the literature, but they suffer from numerical instability when the media transitions are sharp. We use one of these models in the limit of pure vacuum derived from Liu and Yan [Appl. Math. MODEL 38, 1710 (2014)AMMODL0307-904X10.1016/j.apm. 2013.09. 009] and apply an extension that treats the effects of polarization and magnetization separately. We show simulations of simple examples in which EM waves travel into media to quantify error scaling, stability, accuracy, and time scaling. For conductive media, we use the Strang splitting and check the simulations accuracy at the example of the skin effect. Like pure EM propagation, the error for the static limits, which are constructed with a current density added in a first-order scheme, can be less than 1%. The presented method is an easily implemented alternative for the stabilization of simulation for EM waves propagating in spatially complex structured media properties and arbitrary transitions.
Spontaneous Skepticism: The Interplay of Motivation and Expectation in Responses to Favorable and Unfavorable Medical Diagnoses

The quantity of processing view of motivated reasoning predicts that individuals are more likely to spontaneously question the validity of unfavorable than favorable feedback even when the objective likelihood of the feedback is equivalent. Participants were videotaped self-administering a bogus medical test revealing either a favorable or an unfavorable result. In Studies 1 and 2, unfavorable result participants required more time to accept the validity of the test result and were more likely to spontaneously recheck its validity than were favorable result participants. However, unfavorable results also were perceived as less expected than were favorable results, even though the information sup-plied about their objective likelihood was identical. Study 3 showed that participants evaluating another student's results perceived favorable and unfavorable outcomes as equally likely, suggesting that the subjective likelihood of positive and negative feedback is also subject to motivational influence.
An empirical test of source–sink dynamics induced by hunting

Summary 1 Under the source–sink model, persistence of populations in habitat sinks, where deaths outnumber births, depends on dispersal from high-quality habitat sources, where births outnumber deaths. The persistence of the regional population depends on the proportion of sink relative to source habitat. 2 Hunting that occurs in some parts of the landscape and not in others can create patches where deaths outnumber births. We tested whether hunting of culpeo foxes Pseudalopex culpaeus, which is patchily distributed in relatively homogeneous habitat in Argentine Patagonia, induces source–sink dynamics. 3 On Patagonian sheep ranches, culpeos are hunted for fur and to protect sheep, and on cattle ranches hunting is usually banned. We monitored culpeo densities using scent stations and estimated survival, fecundity and dispersal by radio-tracking 44 culpeos and analysing carcasses collected from hunters on two cattle and four sheep ranches between 1989 and 1997. 4 Survival of juvenile culpeos was lower on hunted than unhunted ranches, mainly as a result of hunting mortality. Reproduction could not compensate for high mortality on hunted ranches. Interruption of hunting led to an increase in juvenile survival, indicating that hunting and natural mortality were not compensatory. We concluded that sheep ranches were sinks because of the high mortality and that sink populations may be maintained by dispersal from cattle ranches. 5 We used a simulation model to assess implications of changes in the proportion of source and sink areas on population dynamics. The percentage of land on cattle ranches in the study area was 37%. Current hunting pressure on culpeos would not be sustainable if that percentage fell below 30%. 6 Synthesis and applications. Source–sink dynamics may occur in landscapes where hunting is intense and spatially heterogeneous. Wildlife management traditionally monitors demographic rates to evaluate the sustainability of hunting, but our results suggest that the size and spatial arrangement of areas with and without hunting should be considered as well. In regions where enforcement and monitoring are limited, securing large and regularly distributed source areas for hunted species may be more effective than trying to regulate harvest size.
Climate Change in the South American Monsoon System: Present Climate and CMIP5 Projections

AbstractThe South American monsoon system (SAMS) is the most important climatic feature in South America. This study focuses on the large-scale characteristics of the SAMS: seasonal amplitudes, onset and demise dates, and durations. Changes in the SAMS are investigated with the gridded precipitation, Climate Forecast System Reanalysis (CFSR), and the fifth phase of the Coupled Model Intercomparison Project (CMIP5) simulations for two scenarios [“historical” and high-emission representative concentration pathways (rcp8.5)]. Qualitative comparisons with a previous study indicate that some CMIP5 models have significantly improved their representation of the SAMS relative to their CMIP3 versions. Some models exhibit persistent deficiencies in simulating the SAMS. CMIP5 model simulations for the historical experiment show signals of climate change in South America. While the observational data show trends, the period used is too short for final conclusions concerning climate change. Future changes in the SAMS .
Straining soft colloids in aqueous nematic liquid crystals

Significance Liquid crystals (LCs) are anisotropic, viscoelastic fluids that can be used to direct colloids (e.g., metallic nanorods) into organized assemblies with unusual optical, mechanical, and electrical properties. In past studies, the colloids have been sufficiently rigid that their individual shapes and properties have not been strongly coupled to elastic stresses imposed by the LCs. Herein, we explore how soft colloids (micrometer-sized shells formed from phospholipids) behave in LCs. We reveal a sharing of strain between the LC and shells, resulting in formation of spindle-like shells and other complex shapes and also, tuning of properties of the shells (e.g., barrier properties). These results hint at previously unidentified designs of reconfigurable soft materials with applications in sensing and biology. Liquid crystals (LCs), because of their long-range molecular ordering, are anisotropic, elastic fluids. Herein, we report that elastic stresses imparted by nematic LCs can dynamically shape soft colloids and tune their physical properties. Specifically, we use giant unilamellar vesicles (GUVs) as soft colloids and explore the interplay of mechanical strain when the GUVs are confined within aqueous chromonic LC phases. Accompanying thermal quenching from isotropic to LC phases, we observe the elasticity of the LC phases to transform initially spherical GUVs (diameters of 2–50 µm) into two distinct populations of GUVs with spindle-like shapes and aspect ratios as large as 10. Large GUVs are strained to a small extent (R/r < 1.54, where R and r are the major and minor radii, respectively), consistent with an LC elasticity-induced expansion of lipid membrane surface area of up to 3% and conservation of the internal GUV volume. Small GUVs, in contrast, form highly elongated spindles (1.54 < R/r < 10) that arise from an efflux of LCs from the GUVs during the shape transformation, consistent with LC-induced straining of the membrane leading to transient membrane pore formation. A thermodynamic analysis of both populations of GUVs reveals that the final shapes adopted by these soft colloids are dominated by a competition between the LC elasticity and an energy (∼0.01 mN/m) associated with the GUV–LC interface. Overall, these results provide insight into the coupling of strain in soft materials and suggest previously unidentified designs of LC-based responsive and reconfigurable materials.
Cellular Robustness Conferred by Genetic Crosstalk Underlies Resistance against Chemotherapeutic Drug Doxorubicin in Fission Yeast

Doxorubicin is an anthracycline antibiotic that is among one of the most commonly used chemotherapeutic agents in the clinical setting. The usage of doxorubicin is faced with many problems including severe side effects and chemoresistance. To overcome these challenges, it is important to gain an understanding of the underlying molecular mechanisms with regards to the mode of action of doxorubicin. To facilitate this aim, we identified the genes that are required for doxorubicin resistance in the fission yeast Schizosaccharomyces pombe. We further demonstrated interplay between factors controlling various aspects of chromosome metabolism, mitochondrial respiration and membrane transport. In the nucleus we observed that the subunits of the Ino80, RSC, and SAGA complexes function in the similar epistatic group that shares significant overlap with the homologous recombination genes. However, these factors generally act in synergistic manner with the chromosome segregation regulator DASH complex proteins, possibly forming two major arms for regulating doxorubicin resistance in the nucleus. Simultaneous disruption of genes function in membrane efflux transport or the mitochondrial respiratory chain integrity in the mutants defective in either Ino80 or HR function resulted in cumulative upregulation of drug-specific growth defects, suggesting a rewiring of pathways that synergize only when the cells is exposed to the cytotoxic stress. Taken together, our work not only identified factors that are required for survival of the cells in the presence of doxorubicin but has further demonstrated that an extensive molecular crosstalk exists between these factors to robustly confer doxorubicin resistance.
Colorectal cancer patients’ attitudes towards involvement in decision making

Objectives To design and administer an attitude rating scale, exploring colorectal cancer patients’ views of involvement in decision making. To examine the impact of socio‐demographic and/or treatment‐related factors on decision making. To conduct principal components analysis to determine if the scale could be simplified into a number of factors for future clinical utility.
Taxonomic homogenization of woodland plant communities over 70 years

Taxonomic homogenization (TH) is the increasing similarity of the species composition of ecological communities over time. Such homogenization represents a form of biodiversity loss and can result from local species turnover. Evidence for TH is limited, reflecting a lack of suitable historical datasets, and previous analyses have generated contrasting conclusions. We present an analysis of woodland patches across a southern English county (Dorset) in which we quantified 70 years of change in the composition of vascular plant communities. We tested the hypotheses that over this time patches decreased in species richness, homogenized, or shifted towards novel communities. Although mean species richness at the patch scale did not change, we found increased similarity in species composition among woodlands over time. We concluded that the woodlands have undergone TH without experiencing declines in local diversity or shifts towards novel communities. Analysis of species characteristics suggested that these changes were not driven by non-native species invasions or climate change, but instead reflected reorganization of the native plant communities in response to eutrophication and increasingly shaded conditions. These analyses provide, to our knowledge, the first direct evidence of TH in the UK and highlight the potential importance of this phenomenon as a contributor to biodiversity loss.
Conservation of Chitin-Induced MAPK Signaling Pathways in Rice and Arabidopsis

Perception of microbe-associated molecular patterns (MAMPs) including chitin by pattern recognition receptors (PRRs) rapidly induces activation of mitogen-activated protein kinase (MAPK) cascades. However, how PRRs transmit immune signals to the MAPK cascade is largely unknown. Recently, Arabidopsis receptor-like cytoplasmic kinase PBL27 has been reported to activate MAPKs through phosphorylation of AtMAPKKK5 in the chitin signaling pathway. In this study, we found that OsRLCK185, a rice ortholog of PBL27, regulates chitin-induced MAPK activation in a similar fashion to PBL27 in rice. Upon chitin perception, OsRLCK185 is phosphorylated by OsCERK1, a component of the chitin receptor complex. OsRLCK185 interacted with OsMAPKKK11 and OsMAPKKK18, rice orthologs of AtMAPKKK5, in yeast two-hybrid assays. Silencing of both OsMAPKKK11 and OsMAPKKK18 significantly reduced chitin-induced activation of OsMPK3 and OsMPK6. Expression levels of OsMAPKKK18 were much higher than that of OsMAPKKK11 in rice cells, which was consistent with the fact that the Osmapkkk11 single mutation did not affect MAPK activation. This result suggested that OsMAPKKK18 plays a more important role than OsMAPKKK11 in the chitin-induced activation of OsMPK3 and OsMPK6. The bimolecular fluorescence complementation (BiFC) experiment indicated that OsRLCK185 interacted with OsMAPKKK18 at the plasma membrane in planta. In vitro phosphorylation experiments showed that OsRLCK185 directly phosphorylates OsMAPKKK18. Furthermore, OsMAPKKK18 interacted with the MAPKK OsMKK4, the upstream component of OsMPK3/6. These results suggested that OsRLCK185 connects the chitin receptor to the MAPK cascade consisting of OsMAPKKK18-OsMKK4-OsMPK3/6. Our data revealed that chitin-induced MAPK activation in rice and Arabidopsis is regulated by common homologous elements.
Rifaximin versus norfloxacin for prevention of spontaneous bacterial peritonitis: a systematic review

Aim The aim of this systematic review is to evaluate the efficacy and safety of rifaximin in the prophylaxis of spontaneous bacterial peritonitis (SBP) as compared with norfloxacin. Methods We searched MEDLINE, CINAHL, Google Scholar and Cochrane databases from inception to January 2017. Reference lists of articles as well as conference proceedings were manually screened. We included studies that recruited patients with cirrhosis and ascites who met the criteria for primary or secondary SBP prophylaxis as defined by the European Association for the Study of the Liver and American Association for the Study of Liver Diseases. Two independent investigators reviewed the studies for eligibility, extracted the data and assessed study quality using the Cochrane risk of bias tool. The primary outcome was occurrence of SBP. Secondary outcomes included mortality and adverse events with therapy. Results Of the 435 studies identified, a total of five were included for full-text review. Four studies were eligible for the systematic review, three of which were randomised controlled trials and one was a prospective observational study. The population examined in majority of studies was primarily hepatitis C cirrhosis. The results of individual studies indicated either superior efficacy of rifaximin or no statistical difference between rifaximin and norfloxacin for SBP prophylaxis. Conclusions Moderate-quality evidence shows that long-term use of rifaximin appears to be a reasonable alternative to norfloxacin for SBP prevention in hepatitis C cirrhosis.
The modulation spectrogram: in pursuit of an invariant representation of speech

Understanding the human ability to reliably process and decode speech across a wide range of acoustic conditions and speaker characteristics is a fundamental challenge for current theories of speech perception. Conventional speech representations such as the sound spectrogram emphasize many spectro-temporal details that are not directly germane to the linguistic information encoded in the speech signal and which consequently do not display the perceptual stability characteristic of human listeners. We propose a new representational format, the modulation spectrogram, that discards much of the spectro-temporal detail in the speech signal and instead focuses on the underlying, stable structure incorporated in the low-frequency portion of the modulation spectrum distributed across critical-band-like channels. We describe the representation and illustrate its stability with color-mapped displays and with results from automatic speech recognition experiments.
Academic Functioning and Mental Health in Adolescence

The current study examines patterns of academic functioning and mental health in 184 middle school children and the relation of such patterns to their prior and subsequent functioning. Data were collected from children during their second, third, fourth, eighth, and ninth grade school years. Cluster analyses were used to delineate patterns of academic functioning and mental health during eighth grade. The authors examined the relation of these patterns to academic functioning and mental health 1 year later the transition to high school, and then examined the long-term developmental roots of the eighth grade patterns using data collected during elementary school years. Results indicated variegated patterns of academic and emotional functioning at eighth grade and stability in these patterns across the high school transition. Some long-term continuity was found among children showing uniformly positive or negative functioning at eighth grade. Studying child functioning across multiple domains and time periods is discussed.
Role of tumor‐associated macrophages in hematological malignancies

The tumor microenvironment consists of many non‐tumor cells such as leukocytes, endothelial cells, and fibroblasts, and phenotypic changes in a tumor microenvironment are believed to be involved in tumor progression and resistance to anticancer treatments. In hematological malignancies, tumor‐associated macrophages (TAMs) that have infiltrated lymphoma or leukemia tissues may be involved in tumor progression, and many researchers have studied phenotypic changes in TAMs. This review article summarizes the publications related to TAMs in hematological malignancies, with an emphasis on CD163+ protumoral TAMs, which seem to be associated with disease progression. Cell‐cell interactions between protumoral TAMs and lymphoma or leukemia cells may play an important role in lymphoma or leukemia microenvironments. Although detailed molecular mechanisms of these cell‐cell interactions have not yet been clarified, phenotypic characterization of TAMs is thought to be a useful approach for evaluating clinical prognosis. In addition, targeting TAMs may be a new strategy for treating malignant hematological diseases.