Miracle-dz/UniFAR-FTUs huggingface dataset:
Contrast-enhanced MR angiography of intracranial giant aneurysms.

BACKGROUND AND PURPOSE Intravoxel phase dispersion and flow saturation often prevent adequate depiction of intracranial giant aneurysms on 3D time-of-flight (3D-TOF) MR angiography (MRA). Additional diagnostic difficulties may arise from T1 contamination artifact of an associated blood clot. Our aim was to assess whether contrast-enhanced MRA could improve the evaluation of giant aneurysms and to compare two different types of contrast-enhanced MRA. METHODS We studied 11 aneurysms in 10 patients (age range, 31-77 years) with giant aneurysms of the anterior (n = 9) and posterior (n = 2) cerebral circulation by comparing 3D-TOF, first-pass dynamic contrast-enhanced MRA, and steady-state contrast-enhanced 3D-TOF sequences. Additional comparison with digital subtraction angiography (DSA) was performed in eight aneurysms. RESULTS In nine of 11 aneurysms, 3D-TOF did not adequately show the lumen and exiting vessels. Contrast-enhanced 3D-TOF and dynamic contrast-enhanced MRA showed the aneurysm sac and exiting vessels in all of these cases. Dynamic contrast-enhanced MRA showed a better intravascular contrast than did contrast-enhanced 3D-TOF, which led to better delineation of the aneurysms. T1 contamination artifact from intra- or extraluminal blood clot was evident on the 3D-TOF images in four cases. The artifact was less marked on the contrast-enhanced 3D-TOF image and was completely eliminated on the dynamic contrast-enhanced MRA image by subtraction of precontrast images. The diagnostic information provided by dynamic contrast-enhanced MRA was comparable to that provided by DSA. CONCLUSION Precontrast 3D-TOF is inadequate for the assessment of giant cerebral aneurysms. Both contrast-enhanced 3D-TOF and dynamic contrast-enhanced MRA reliably show the aneurysm sac and connected vessels. Dynamic MRA provides a superior contrast between flow and background and eliminates T1 contamination artifact. It should therefore be considered as the MRA sequence of choice.
GENETIC VARIATION IN THREE BREEDS OF INDONESIAN LOCAL DUCKS BASED ON BLOOD AND EGG WHITE PROTEIN POLYMORPHISM

A study of genetic variation of four blood protein loci and three egg white loci in three breeds ofIndonesian local ducks (Magelang duck = MAD, Tegal duck = TED and Mojosari duck= MOD) wasinvestigated by using polyacrilamide gel electrophoresis (PAGE). The result showed that four bloodprotein loci (Pre-albumin, Albumin, Transferrin and Post-transferrin) and three egg white loci(Ovalbumin, Ovoglobulin and Conalbumin) were found to be polymorphic in three breeds of localducks. There was no difference on blood and egg white protein polyimorphism. The average value ofheterozygosity on three breeds of local ducks had a genetic potential to determine the controlled matingsystem and selection to obtain pure line. The closest phylogenetic relationship among the three breeds oflocal ducks occurred between MAD and TED.
Mechanical and Electrical Modeling of Strands in Two ITER CS Cable Designs

Following the test of the first Central Solenoid (CS) conductor short samples for the International Thermonuclear Experimental Reactor (ITER) in the SULTAN facility, Iter Organization (IO) decided to manufacture and test two alternate samples using four different cable designs. These samples, while using the same Nb3Sn strand, were meant to assess the influence of various cable design parameters on the conductor performance and behavior under mechanical cycling. In particular, the second of these samples, CSIO2, aimed at comparing designs with modified cabling twist pitches sequences. This sample has been tested, and the two legs exhibited very different behaviors. To help understand what could lead to such a difference, these two cables were mechanically modeled using the MULTIFIL code, and the resulting strain map was used as an input into the CEA electrical code CARMEN. This article presents the main data extracted from the mechanical simulation and its use into the electrical modeling of individual strands inside the CICC.
Assessment of Effects of Physical or Chemical Factors on Fat Particle Viability by Glucose Transport Test

BackgroundIt is important to protect fat viability during grafting. This study aimed to clarify whether physical or chemical factors damage fat viability. MethodsFat was harvested under high and low tumescence pressure, using syringes and a liposuction machine; this fat was injected through different gauge needles and cultured with lidocaine or epinephrine. Samples were subjected to glucose transport test and observed histologically. ResultThe viability and microstructure of fat harvested under high and low tumescence pressure, and by syringe and liposuction machine, were similar (P > 0.05). The viability and intactness of fat cells injected through needles decreased with decreasing needle diameter (P < 0.05). Lidocaine (P < 0.05) and epinephrine (P < 0.05) weakened fat viability. ConclusionsFat used for grafting can be harvested by tumescent techniques and a liposuction machine. Fat cell viability during injection increases with increasing needle diameter. Fat should be purified to remove drugs.
On the utility of the molecular oxygen dayglow emissions as proxies for middle atmospheric ozone

Martin G. MlynczakNASA Langley Research Center, Hampton, VirginiaDaphne S. Olander 1Science Applications International Corporation, Hampton, VirginiaAbstract. The molecular oxygen dayglow emissions,O2(alAg -_ X3Eg) at 1.27 gm and O2(blEg --_X3Eg) at 762 nm,arise in part from processes related to the Hartley band photolysisof ozone. It is therefore possible to derive daytime ozoneconcentrations from measurements of the volume emission rateof either dayglow. The accuracy to which the ozoneconcentration can be inferred depends on the accuracy to whichnumerous kinetic and spectroscopic rate constants are known,including rates which describe the excitation of molecular oxygenby processes that are not related to the ozone concentration. Wefind that several key rate constants must be known to better than7% accuracy in order to achieve an inferred ozone concentrationaccurate to 15% from measurements of either dayglow.Currently, accuracies for various parameters typically range from5 % to 100%.
The Virtual Seismologist in SeisComP3: A New Implementation Strategy for Earthquake Early Warning Algorithms

The feasibility of earthquake early warning (EEW) is now widely recognized. However, EEW systems that are in operation or under evaluation worldwide have significant variations and are usually operated independently of routine earthquake monitoring. We introduce a software that allows testing and evaluation of a well‐known EEW algorithm directly within a widely used earthquake monitoring software platform. In the long term, we envision this approach can lead to (1) an easier transition from prototype to production type EEW implementations, (2) a natural and seamless evolution from very fast EEW source parameter estimates with typically large uncertainties to more delayed but more precise estimates using more traditional analysis methods, and (3) the capability of seismic networks to evaluate the readiness of their network for EEW, and to implement EEW, without having to invest in and maintain separate, independent software systems. Using the Virtual Seismologist (VS), a popular EEW algorithm that has been tested in real time in California since 2008, we demonstrate how our approach can be realized within the widely used monitoring platform SeisComP3. Because this software suite is already in production at many seismic networks worldwide, we have been able to test the new VS implementation across a wide variety of tectonic settings and network infrastructures. Using mainly real‐time performance, we analyze over 3200 events with magnitudes between 2.0 and 6.8 and show that, for shallow crustal seismicity, 68% of the first VS magnitude estimates are within ±0.5 magnitude units of the final reported magnitude. We further demonstrate the very significant effect of data communication strategies on final alert times. Using a Monte Carlo simulation approach, we then model the best possible alert times for optimally configured EEW systems and show that, for events within the dense parts of each of the seven test networks, effective warnings could be issued for magnitudes as small as M 5.0.
Early weaning of calves after different dietary regimens affects later rumen development, growth, and carcass traits in Hanwoo cattle

Objective The main objective of this study was to determine the effect of different diets for early-weaned (EW) calves on rumen development, and how this affects fat deposition in the longissimus dorsi of adult Korean Hanwoo beef cattle. Methods Three EW groups were established (each n = 12) in which two- week-old Hanwoo calves were fed for ten weeks with milk replacer+concentrate (T1), milk replacer+concentrate+ roughage (T2), or milk replacer+concentrate+30% starch (T3); a control group (n = 12) was weaned as normal. At six months, 5 calves of each group were slaughtered and their organs were assessed and rumen papillae growth rates were measured. The remaining calves (n = 7 in each group) were raised to 20 months for further analysis. Results Twenty-month-old EW calves had a higher body weight (BW), backfat thickness (BF), longissimus dorsi muscle area (LMA) and intramuscular fat (IMF) than the control (p<0.05). Organ growth, rumen histology, and gene expression patterns in the 6-month-old calves were positively related to the development of marbling in the loin, as assessed by ultrasound analysis (p<0.05). In the group fed the starch-enriched diet (T3), higher BW, BF, LMA, and IMF were present. The IMF beef quality score of 20-month-old cattle was 1+ for the T2 and T3 diets and 1 for the T1 diet (p<0.05). Conclusion Papillae development was significantly greater in calves fed on high-concentrate diets and this may have resulted in the improved beef quality in the EW dietary groups compared to the control.
Hecke Operations and the Adams E2 -Term Based on Elliptic Cohomology

Abstract Hecke operators are used to investigate part of the ${{E}_{2}}$ -term of the Adams spectral sequence based on elliptic homology. The main result is a derivation of $\text{Ex}{{\text{t}}^{1}}$ which combines use of classical Hecke operators and $p$ -adic Hecke operators due to Serre.
Bayes factors for reinforcement-learning models of the Iowa Gambling Task

The psychological processes that underlie performance on the Iowa gambling task (IGT) are often isolated with the help of reinforcement-learning (RL) models. The most popular method to compare RL models is the BIC post hoc fit criterion—a criterion that considers goodness-of-fit relative to model complexity. However, the current implementation of the BIC post hoc fit criterion considers only 1 dimension of model complexity, that is, the number of free parameters. A more sophisticated implementation of the BIC post hoc fit criterion, 1 that provides a coherent and complete discounting of complexity, is provided by the Bayes factor. Here we demonstrate an analysis in which Bayes factors are obtained with a Monte Carlo method, known as importance sampling, to compare 4 RL models of the IGT: the Expectancy Valence (EV), Prospect Valence Learning (PVL), PVL-Delta, and Value-Plus-Perseveration (VPP) models. We illustrate the method using a data pool of 771 participants from 11 different studies. Our results provide strong evidence for the VPP model and moderate evidence for the PVL model, but little evidence for the EV and PVL-Delta models—results that were not in line with a BIC post hoc fit analysis. We discuss how our results may be combined with results obtained from other model comparison studies to obtain a balanced and comprehensive assessment of model adequacy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
Risk Management Decision Making in ICT for Development

This paper explores the concept of enterprise resiliency in Information and Communications Technologies (ICT) for development initiatives. ICT are necessary to improve access to vital services and to ultimately support efforts to improve economic conditions in developing regions. Access to information resources provides substantial benefits in the public and private sectors of regions with low standards of living. Success in achieving any benefit from ICT investment in any development enterprise will be directly affected by the resiliency of the ICT systems and services, including technical and non-technical domains. We explore a framework to analyze risks and threats to enterprise resiliency, and present guidance to support the development of resilient ICT for development.
DEMOGRAPHIC, CULTURAL, AND ECONOMIC PREDICTORS OF PERCEIVED ETHICALITY OF NEGOTIATION BEHAVIOR: A NINE-COUNTRY ANALYSIS.

The Lewicki-Robinson (1998) "Incidents in Negotiation" questionnaire measures the perceived ethicality of eighteen negotiation tactics or behaviors. While there is a presumption that the attitudes or intentions measured in this questionnaire are precursors to actual behavior, there have been no studies or direct evidence of a connection. This paper reports on a study examining the links between attitudes, intentions, and behaviors for five tactics from the questionnaire, using a two-party, buyer-seller negotiation to measure behavior. The results of the analysis suggest significant correlations between attitudes and intentions, attitudes and behaviors, and intentions and behaviors for at least four of the five tactics. In addition, there was evidence of a mediating effect of intentions on the attitude-behavior relationship for two of the five tactics.
Lysine Requirement of Male White Pekin Ducklings from Seven to Twenty-one Days of Age

A dose-response experiment with five lysine levels (0.65, 0.80, 0.95, 1.10, and 1.25%) was conducted to evaluate the lysine requirement of male White Pekin ducklings from 7 to 21 days of age. Two hundred and eighty, 7-day-old, male White Pekin ducklings were allocated to 5 experimental treatments, each containing 8 replicate pens with 7 birds per pen. Feed and water were provided ad libitum from 7 to 21 days of age. At 21 days of age, weight gain, feed intake, feed/gain, breast meat weight, and breast meat yield relative to body weight of ducklings from each pen were all measured. As dietary lysine level increased, weight gain, feed intake, feed/gain, breast meat weight, and breast meat yield of ducklings were all improved significantly (p<0.05). According to broken-line regression analysis, the lysine requirement of male White Pekin ducklings from 7 to 21 days of age for weight gain, feed/gain, breast meat weight, and breast meat yield was 0.84, 0.90, 0.97, and 0.98%, respectively. Considering that Pekin duck production is directed to meat production, the lysine requirement of male starter Pekin ducklings during this period is suggested to be 0.98%.
Modeling and analysis of longitudinal multimodal magnetic resonance imaging: Application to early brain development

Many mental illnesses are thought to have their origins in early stages of development, encouraging increased research efforts related to early neurodevelopment. Magnetic resonance imaging (MRI) has provided us with an unprecedented view of the brain in vivo. More recently, diffusion tensor imaging (DTI/DT-MRI), a magnetic resonance imaging technique, has enabled the characterization of the microstrucutral organization of tissue in vivo. As the brain develops, the water content in the brain decreases while protein and fat content increases due to processes such as myelination and axonal organization. Changes of signal intensity in structural MRI and diffusion parameters of DTI reflect these underlying biological changes. Longitudinal neuroimaging studies provide a unique opportunity for understanding brain maturation by taking repeated scans over a time course within individuals. Despite the availability of detailed images of the brain, there has been little progress in accurate modeling of brain development or creating predictive models of structure that could help identify early signs of illness. We have developed methodologies for the nonlinear parametric modeling of longitudinal structural MRI and DTI changes over the neurodevelopmental period to address this gap. This research provides a normative model of early brain growth trajectory as is represented in structural MRI and DTI data, which will be crucial to understanding the timing and potential mechanisms of atypical development. Growth trajectories are described via intuitive parameters related to delay, rate of growth and expected asymptotic values, all descriptive measures that can answer clinical questions related to quantitative analysis of growth patterns. We demonstrate the potential of the framework on two clinical studies: healthy controls (singletons and twins) and children at risk of autism. Our framework is designed not only to provide qualitative comparisons, but also to give researchers and clinicians quantitative parameters and a statistical testing scheme. Moreover, the method includes modeling of growth trajectories of individuals, resulting in personalized profiles. The statistical framework also allows for prediction and prediction intervals for subject-specific growth trajectories, which will be crucial for efforts to improve diagnosis for individuals and personalized treatment.
Regulated Production and Molecular Diversity of Human Liver and Activation-Regulated Chemokine/Macrophage Inflammatory Protein-3α from Normal and Transformed Cells1

Liver and activation-regulated chemokine (LARC), also designated macrophage inflammatory protein-3α (MIP-3α), Exodus, or CCL20, is a C-C chemokine that attracts immature dendritic cells and memory T lymphocytes, both expressing CCR6. Depending on the cell type, this chemokine was found to be inducible by cytokines (IL-1β) and by bacterial, viral, or plant products (including LPS, dsRNA, and PMA) as measured by a specific ELISA. Although coinduced with monocyte chemotactic protein-1 (MCP-1) and IL-8 by dsRNA, measles virus, and IL-1β in diploid fibroblasts, leukocytes produced LARC/MIP-3α only in response to LPS. However, in myelomonocytic THP-1 cells LARC/MIP-3α was better induced by phorbol ester, whereas in HEp-2 epidermal carcinoma cells IL-1β was the superior inducer. The production levels of LARC/MIP-3α (1–10 ng/ml) were, on the average, 10- to 100-fold lower than those of IL-8 and MCP-1, but were comparable to those of other less abundantly secreted chemokines. Natural LARC/MIP-3α protein isolated from stimulated leukocytes or tumor cell lines showed molecular diversity, in that NH2- and COOH-terminally truncated forms were purified and identified by amino acid sequence analysis and mass spectrometry. In contrast to other chemokines, including MCP-1 and IL-8, the natural processing did not affect the calcium-mobilizing capacity of LARC/MIP-3α through its receptor CCR6. Furthermore, truncated natural LARC/MIP-3α isoforms were equally chemotactic for lymphocytes as intact rLARC/MIP-3α. It is concluded that in addition to its role in homeostatic trafficking of leukocytes, LARC/MIP-3α can function as an inflammatory chemokine during host defense.
Tadalafil enhances the inhibitory effects of tamsulosin on neurogenic contractions of human prostate and bladder neck.

INTRODUCTION Lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH-LUTSs) may be associated with erectile dysfunction (ED). Phosphodiesterase type 5 (PDE5) inhibitors used for treating ED have shown clinical benefit in patients with LUTS but their actions in human LUT tissues are not well defined. AIM To determine the effects of the long-acting PDE5 inhibitor, tadalafil, on smooth muscle tone in human prostate and bladder neck as well as to evaluate the influence of tadalafil on the efficacy of the α-adrenergic receptor antagonist, tamsulosin, in inhibiting contractile responses in these tissues. METHODS Strips of human peripheral prostate (HPP), human internal prostate (HIP), and human bladder neck (HBN) were obtained from organ donors and patients with BPH. The strips were then disposed in organ baths to evaluate nitric oxide/cyclic guanosine monophosphate (cGMP)-mediated relaxation and cGMP kinetics in HPP and HIP, and electrical field stimulation (EFS)-induced neurogenic contractions in HPP and HBN. MAIN OUTCOME MEASURES Tadalafil-induced effects on sodium nitroprusside (SNP)-induced relaxation and cGMP accumulation in HPP and HIP and influence of tadalafil and tamsulosin on EFS-induced contractions of HPP and HBN. RESULTS SNP-induced relaxation of HPP and HIP was significantly potentiated by tadalafil (30-60 nM). SNP-induced cGMP accumulation in HPP and HIP was enhanced by tadalafil (30-60 nM), but significant difference was only obtained in HPP. EFS-induced contractions sensitive to tetrodotoxin in HPP were significantly inhibited by tadalafil (30 nM) but not by tamsulosin (0.01-100 nM) or vehicle. Further inhibition of neurogenic responses in HPP was achieved by combining tadalafil and tamsulosin treatments. Tamsulosin, but not tadalafil, significantly reduced EFS-induced contractions in HBN, but the coadministration of both therapies resulted in additional inhibition of contractions. CONCLUSIONS While tadalafil enhances cGMP accumulation and potentiates prostate relaxation, tadalafil combined with tamsulosin results in enhanced inhibition of neurogenic contractions of HPP and HBN.
The Effect of Moment of Inertia on the Liquids in Centrifugal Microfluidics

The flow of liquids in centrifugal microfluidics is unidirectional and dominated by centrifugal and Coriolis forces (i.e., effective only at T-junctions). Developing mechanisms and discovering efficient techniques to propel liquids in any direction other than the direction of the centrifugal force has been the subject of a large number of studies. The capillary force attained by specific surface treatments, pneumatic energy, active and passive flow reciprocation and Euler force have been previously introduced in order to manipulate the liquid flow and push it against the centrifugal force. Here, as a new method, the moment of inertia of the liquid inside a chamber in a centrifugal microfluidic platform is employed to manipulate the flow and propel the liquid passively towards the disc center. Furthermore, the effect of the moment of inertia on the liquid in a rectangular chamber is evaluated, both in theory and experiments, and the optimum geometry is defined. As an application of the introduced method, the moment of inertia of the liquid is used in order to mix two different dyed deionized (DI) waters; the mixing efficiency is evaluated and compared to similar mixing techniques. The results show the potential of the presented method for pumping liquids radially inward with relatively high flow rates (up to 23 mm3/s) and also efficient mixing in centrifugal microfluidic platforms.
A QSAR investigation of the role of hydrophobicity in regulating mutagenicity in the ames test: 1. Mutagenicity of aromatic and heteroaromatic amines in Salmonella typhimurium TA98 and TA100

Quantitative structure‐activity relationships (QSAR) have been derived for the mutagenic activity of 88 aromatic and heteroaromatic amines acting on Salmonella typhimurium TA98 + S9 and 67 amines acting on TA100 + S9. Mutagenic activity is linearly dependent on hydrophobicity, the energy of the highest occupied molecular orbital, and the energy of the lowest unoccupied molecular orbital of the amine. The dependence of mutagenic activity on hydrophobicity and electronic effects is nearly identical for TA98 and TA100. Mutagenic activity in TA98 is also found to depend on the size of the aromatic ring system. Different QSARs are derived for the mutagenic activity of hydrophilic amines (log P < 1) acting on either TA98 or TA100. The mechanism of amine activation and reaction with DNA is considered in light of these findings.