Miracle-dz/UniFAR-FTUs huggingface dataset:
Tool Condition Monitoring and Remaining Useful Life Prognostic Based on a Wireless Sensor in Dry Milling Operations

Tool breakage causes losses of surface polishing and dimensional accuracy for machined part, or possible damage to a workpiece or machine. Tool Condition Monitoring (TCM) is considerably vital in the manufacturing industry. In this paper, an indirect TCM approach is introduced with a wireless triaxial accelerometer. The vibrations in the three vertical directions (x, y and z) are acquired during milling operations, and the raw signals are de-noised by wavelet analysis. These features of de-noised signals are extracted in the time, frequency and time–frequency domains. The key features are selected based on Pearson’s Correlation Coefficient (PCC). The Neuro-Fuzzy Network (NFN) is adopted to predict the tool wear and Remaining Useful Life (RUL). In comparison with Back Propagation Neural Network (BPNN) and Radial Basis Function Network (RBFN), the results show that the NFN has the best performance in the prediction of tool wear and RUL.
TMS of V1 eliminates unconscious processing of chromatic stimuli

Some of the neurological patients with primary visual cortex (V1) lesions can guide their behavior based on stimuli presented to their blind visual field. One example of this phenomenon is the ability to discriminate colors in the absence of awareness. These so-called patients with blindsight must have a neural pathway that bypasses the V1, explaining their ability to unconsciously process stimuli. To test if similar pathways function in neurologically healthy individuals or if unconscious processing depends on the V1, we disturbed the visibility of a chromatic stimulus with metacontrast masking (Experiment 1) or transcranial magnetic stimulation (TMS) of the V1 (Experiment 2). We measured unconscious processing using the redundant target effect (RTE), which is the speeding up of reaction times in response to dual stimuli compared with one stimulus, when the task is to respond to any number of stimuli. An unconscious chromatic RTE was found when the visibility of the redundant chromatic stimulus was suppressed with a visual mask. When TMS was applied to the V1 to disturb the perception of the redundant chromatic stimulus, the RTE was eliminated. Based on our results and converging evidence from previous studies, we conclude that the unconscious processing of chromatic information depends on the V1 in neurologically healthy participants.
Coding across Sensory Modalities: Integrating the Dynamic Face with the Voice

Primates are social beings. To ensure adequate resources and advance their position in a dominance hierarchy, they must be Machiavellian—ready to exploit social opportunities whenever they appear (Ghazanfar and Santos, 2004; Maestripieri, 2007). Maintenance and the advancement of rank in a social hierarchy entail a range of behaviors such as play, grooming, aggressive attacks, submissive retreats, reconciliations and the formation of coalitions (Cheney and Seyfarth, 1990; Ghazanfar and Santos, 2004; Maestripieri, 2007). Achieving adaptive social behavior requires that primates monitor and accurately perceive the vocal communication signals of conspecifics (Cheney and Seyfarth, 1990; Semple, 1998; Pfefferle et al., 2008). Primate vocalizations are complex—often extended and dynamic with temporal structure on a variety of time scales. Furthermore, these vocalizations are not produced in quiet environments. Instead, they are often embedded in a variety of other biotic and abiotic sounds (Waser and Brown, 1986; Slabbekoorn, 2004; Chandrasekaran et al., 2010b). Therefore, one major task of the primate brain is to extract conspecific vocalizations from these background sounds. How do primate brains robustly perceive vocal communication signals embedded in this noisy background? One potential solution is to not rely exclusively on the auditory input but combine it with cues from other senses, and thereby disambiguate and enhance the robustness of 13
A Delphi study investigating consensus among expert physiotherapists in relation to the management of low back pain.

OBJECTIVES Low back pain (LBP) affects a large proportion of the adult population, with over 90% of people expected to experience symptoms associated with it. LBP is one of the most common conditions managed by primary health care practitioners, and physiotherapists are the largest professional group responsible for its management. Clinical guidelines exist for the management of LBP and are based on the best available evidence. However, there is currently no consensus on the actual physiotherapy management of this condition. METHODS A three-round Delphi study was conducted among expert physiotherapists (n = 34). A focus group was initially convened to review the key questions, developed following a review of the literature. An expert panel then produced their responses, which were ranked in subsequent rounds, using a five-point Likert scale, until a predetermined point of consensus was reached. RESULTS The results of this study indicated that it is possible to establish consensus among expert clinicians in relation to the management of LBP, with consensus reached on 64 (67.3%) of the 95 responses identified. The results also showed that, in general, physiotherapy management within the location studied conformed to current LBP evidence-based clinical guidelines. In addition, the expert panel identified the importance of a biopsychosocial approach to LBP management. CONCLUSIONS Although the study identified that consensus existed in relation to many aspects of physiotherapy management of LBP, it was also noted that confusion existed in relation to several key areas of practice, highlighting the need for further work.
Homocysteine May Involve in the Pathogenesis of Behcet's Disease by Inducing Inflammation

Objective. Our aim was to evaluate the significance of homocysteine (Hcy) in Behcet's disease (BD) and the association of elevated Hcy levels associated with the indices of inflammation in BD. Methods. Untreated 70 patients with BD and 33 healthy individuals were included into the study. Hcy, tumor necrosis alpha (TNF-α), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated with respect to activity and specific individual clinical manifestations of the disease. Results. Hcy levels were found significantly elevated in active BD when compared to inactive BD and healthy controls. Hcy levels were found to have high correlation with the number of active clinical manifestations increased. A significant positive correlation was found between serum Hcy and TNF-α levels, CRP, and ESR. Hcy was found to be the best predictor of TNF-α among other parameters. Conclusion. Hcy may involve in the pathogenesis of BD by inducing inflammation.
The biology of Zymomonas

INTRODUCTION . 2 OCCURRENCE OF ZYMOMONAS AND HISTORY OF ISOLATIONS . 2 Ciders and Perries . 2 Fermenting Agave Sap . , 5 Beer. 5 Fermenting Palm Sap. 6 Fermenting Sugarcane Sap . 8 Ripening Honey . 9 Some Technological Applications . 9 Therapeutic Use . 10 History of Individual Strains . 10 DETECTION, ISOLATION, AND IDENTIFICATION OF THE GENUS ZYMOMONAS . 10 Detection . 10 Isolation. 10 Identification. 11 Some Commonly Used Media and Growth Conditions . 11 TAXONOMY OF ZYMOMONAS. 13 Numerical Analysis of the Phenotype . 13 DNA Base Composition and DNA Genome Size . 15 Genome-DNA Relatedness . 15 Similarity of Protein Electropherograms . 16 Infrared Spectra of Intact Cells. 16 Serology . 16 Classification and Nomenclature . 18 Relationship Between Zgmomonas and Other Genera . 20 PHENOTYPICAL DESCRIPTION: MORPHOLOGY, GROWTH, PHYSIOLOGY, AND BIOCHEMISTRY . 22 The Cell . 22 Cell morphology . 22 Macromorphology . 22 Cellular composition . 22 Resting cells and starvation . 23 Growth Response to Different Conditions . 23 Growth in some ordinary media . 23 Growth in the liquid synthttic medium of Kluyver and Hoppenbrouwers . 23 Growth at different pH values . 23 Growth at different temperatures . 24 Thermal death point . 24 Growth in the presence of ethanol . 24 Growth in high glucose concentrations . 24 Growth in the presence of KCN . 24 Growth in the presence of NaCl . 24 Growth in the presence of 0.01% Acti-dione . 24 Growth in the presence of oxgall . 24 Growth in the presence of 0.1% 2,3,5-triphenyltetrazolium chloride . 24 Growth in the presence of 0.01% thallium acetate . 25 Growth in the presence of 0.001% cadmium sulfate . 25 Growth in the presence of the vibriostatic agent 0/129 . 25 Tolerance to SO . 25 Growth in the presence of dyes . 25 Reduction of dyes and HgC12 . 25 Growth in the presence of antibiotics . 25 Carbohydrate Metabolism . 25 Metabolism of glucose and fructose . 25 Metabolism of sucrose: fermentation and levan formation . 29 Other carbon sources . 29 Formation of acetaldehyde. 30
The initial meadows

Abstract A meadow is a commutative ring with an inverse operator satisfying 0−1 = 0. We determine the initial algebra of the meadows of characteristic 0 and prove a normal form theorem for it. As an immediate consequence we obtain the decidability of the closed term problem for meadows and the computability of their initial object.
Can the social model explain all of disability experience? Perspectives of persons with chronic fatigue syndrome.

OBJECTIVE The social model of disability has had a major influence on the academic field of disability studies and on contemporary understandings of the causes and experience of disability. The purpose of this study was to examine the adequacy of the social model for explaining the disability experience of persons with chronic fatigue syndrome (CFS). METHODS This qualitative study examined the experiences of 47 adults with CFS participating in a research project that aimed to evaluate a participant-designed rehabilitation program. Data were aggregated from focus group interviews, open-ended questionnaires, progress notes, and from a program evaluation questionnaire. Data analysis was based on a grounded theory approach and used triangulation of multiple data sources and member checks to assure dependability of findings. RESULTS Four themes emerged from the analysis: (1) minimization and mistrust of the disability; (2) negative experiences of impairment; (3) lack of identification with the disability community; and (4) the focus on advocacy as a quest for legitimacy. These themes varied in the extent to which they conformed to the principles set forth by the social model. CONCLUSIONS Although the social model has important contributions to lend to occupational therapy practice, it is important to recognize that it may not capture the full reality of disability. In particular, the social model has serious limitations in describing the disability experience of individuals with disabilities who do not have visibly obvious disabilities and whose impairments do not conform to the traditional viewpoint of disability.
Numerical Analysis of the Mesoscale Dynamics of an Extreme Rainfall and Flood Event in Sri Lanka in May 2016

In this present study, we analyzed the synoptic and mesoscale dynamics and underlying mechanism of an extreme rainfall and flood event that occurred in Sri Lanka between 14 – 17 May 2016, using the Weather Research and Forecasting Model simulations with a horizontal grid size of 3 km and observational data. This extreme rainfall event was associated with a low-pressure system (LPS) that originated over the Bay of Bengal in the Indian Ocean and passed over Sri Lanka. The observed maximum accumulation of rainfall during the event exceeded 300 mm at several weather stations on 15 – 16 May and it resulted in severe flooding and landslides, particularly in the western part of the island. The model closely simulated the timing of the initiation of the LPS and its development along the east coast of Sri Lanka. The model could capture the overall rainfall tendency and pattern of this event. Synoptic and mesoscale analyses indicated that this extreme rainfall event occurred as the cumulative effect of a sustained low-level convergence zone, generated by an enhanced westerly monsoon flow and the circulation of the LPS, alongside a continuous supply of high-magnitude moisture, strong vertical motion, and orographic effects of the Central Mountains of Sri Lanka. Model sensitivity experiments indicated that the rainfall over the western slope area of the mountains was enhanced by mountain lifting, whereas western coastal rainfall was reduced because the mountains blocked the northeasterly flow of the LPS.
Effectiveness of HPV 16 viral load and the E2/E6 ratio for the prediction of cervical cancer risk among Chinese women

The effectiveness of the E2/E6 ratio, the state of viral genome integration and the viral load of human papillomavirus 16 (HPV 16) in predicting the risk of cervical cancer among Chinese women was investigated. Quantitative PCRs for the E2/E6 ratio and the viral load were performed on 85 cervical cancer samples and 55 HPV 16 positive healthy controls. The integrated form of the viral genome was found in 10.9% control samples and in 26.4% cervical cancer samples (P = 0.02). The majority of the cervical cancer (63.2%) and control samples (60%) were mixed forms. The E2/E6 ratio was associated with a high risk of cervical cancer (OR = 7.29, P = 9.55E−6). The integrated form (OR = 6.54, P = 0.005) and mixed form (OR = 2.93, P = 0.042) increased the risk of cervical cancer. The mean viral load in cervical cancer samples (37,371 ± 227,135) was higher than that in the controls (4,619 ± 27,079; P = 0.011). Additionally, the viral load increased along with the cervical cancer progression from the International Federation of Gynecology and Obstetrics (FIGO) stage I (12,337 ± 25,604) to stage II (67,453 ± 319,821). Compared with the state of viral genome integration (area under the receiver operating characteristic curve (AUC) = 0.743) or the viral load (AUC = 0.694), the E2/E6 ratio improved the effectiveness of the risk prediction of cervical cancer (AUC = 0.777), with the sensitivity (specificity) 81.2% (71.7%). The state of viral genome integration and the viral load of HPV 16 were important factors for the risk prediction of cervical cancer among Chinese women, and the E2/E6 ratio had a better cervical cancer risk prediction with age adjustment. J. Med. Virol. 85:646–654, 2013. © 2013 Wiley Periodicals, Inc.
Ponseti Casting for Severe Club Foot Deformity: Are Clinical Outcomes Promising?

Between 2007 and 2010, a prospective study was done on 85 patients with severe idiopathic nonsyndromic clubfeet, in our center. Demographic features, severity of the deformity before and after serial casting according to Diméglio classification, and complications were assessed. The mean age of the patients was 8 days and 69% were male. The mean follow-up period was 26 months. The average number of castings used to correct the deformity was 5.7 times (range: 4 to 8). Tenotomy was performed in 76 (89.4%) of the feet. In all patients, plantigrade foot was achieved. Tenotomy occurred more in patients with higher Diméglio scores. Although patients who underwent Achilles tenotomy began to walk later than those who did not (13 ± 7.2 versus 9.2 ± 18), it was not significant (P = 0.06). Relapse rate, at the end of follow-up, was 27.1%. Diméglio score before casting was 16 ± 3.4 and at the end of follow-up it was 1.6 ± 6.2. The patients with bilateral clubfeet had inferior final outcome compared to those with unilateral clubfoot. Eighty percent of parents' were completely satisfied with their child's gait and foot appearance (94.1%). Ponseti method of manipulation and casting is a valuable technique in severe club foot as well as in common types.
Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation

Probiotics are commensal or nonpathogenic microbes that confer beneficial effects on the host through several mechanisms such as competitive exclusion, antibacterial effects, and modulation of immune responses. Some probiotics have been found to regulate immune responses via immune regulatory mechanisms. T regulatory (Treg) cells, T helper cell balances, dendritic cells, macrophages, B cells, and natural killer (NK) cells can be considered as the most determinant dysregulated mediators in immunomodulatory status. Recently, fecal microbiota transplantation (FMT) has been defined as the transfer of distal gut microbial communities from a healthy individual to a patient's intestinal tract to cure some immune disorders (mainly inflammatory bowel diseases). The aim of this review was followed through the recent literature survey on immunomodulatory effects and mechanisms of probiotics and FMT and also efficacy and safety of probiotics and FMT in clinical trials and applications.
Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is highly prevalent in South East Asia and China. The poor outcome is due to late presentation, recurrence, distant metastasis and limited therapeutic options. For improved treatment outcome, immunotherapeutic approaches focusing on dendritic and autologous cytotoxic T-cell based therapies have been developed, but cost and infrastructure remain barriers for implementing these in low-resource settings. As our prior observations had found that four-jointed box 1 (FJX1), a tumor antigen, is overexpressed in NPCs, we investigated if short 9–20 amino acid sequence specific peptides matching to FJX1 requiring only intramuscular immunization to train host immune systems would be a better treatment option for this disease. Thus, we designed 8 FJX1-specific peptides and implemented an assay system to first, assess the binding of these peptides to HLA-A2 molecules on T2 cells. After, ELISPOT assays were used to determine the peptides immunogenicity and ability to induce potential cytotoxicity activity towards cancer cells. Also, T-cell proliferation assay was used to evaluate the potential of MHC class II peptides to stimulate the expansion of isolated T-cells. Our results demonstrate that these peptides are immunogenic and peptide stimulated T-cells were able to induce peptide-specific cytolytic activity specifically against FJX1-expressing cancer cells. In addition, we demonstrated that the MHC class II peptides were capable of inducing T-cell proliferation. Our results suggest that these peptides are capable of inducing specific cytotoxic cytokines secretion against FJX1-expressing cancer cells and serve as a potential vaccine-based therapy for NPC patients.
Decreased Lumbar Cerebrospinal Fluid Levels of Monoamine Metabolites in Vascular Dementia

The levels of the monoamine metabolites 5-hydroxy-indoleacetic acid (5-HIAA), homovanillic acid (HVA), and 4-hydroxy-3-methoxyphenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 56 patients with vascular dementia (VAD) and 57 healthy controls. Despite CSF sampling under standardized conditions, the variability in values was wide among both patients and controls. This suggests that yet unknown factors affect the lumbar CSF concentrations of monoamine metabolites. The VAD group showed significantly lower mean concentrations of 5-HIAA (p < .001) and HVA (p < .001) than the control group. These low concentrations appear to be no disease-specific phenomenon, but may be attributable to subcortical white-matter changes or a decreased production of monoamines, which are dependent on oxygen for their synthesis.
Fast Display of Octree Representations of 3 D Objects !

A novel algorithm is proposed for displaying 3D voxel-based binary objects encoded as octrees. It traverses an octree recursively in a front-to-back (FfB) order determined by a given viewing direction and produces a depth image by scan-converting the visible portion of faces of black octants encountered during the traversal. The algorithm is efficient because many obscured nodes are never visited and many obscured faces of partially visible black octants are not processed during the scan-conversion phase. The key to the algorithm is a new technique termed blocking quadtrees, that enables the node visibility test to be performed efficiently and thus minimizes the overhead cost. Complexity analysis and experimental results show that the new algorithm is much faster than the traditional back-tofront (BTF) approach [3] . A 55-79% time reduction is achieved for a 3D 2563 medical image that requires a reasonable amount of extra memory space for storing the blocking quad trees (64 KB for a 256 image).
Mullen Scales of Early Learning: Ags Edition

August 2015 Overview The Mullen Scales of Early Learning: AGS Edition (Mullen, 1995) is an individually administered, standardized measure of cognitive functioning designed to be used with children from birth through 68 months. This update is a revised version of the original Mullen Scales of Early Learning, combining the Infant MSEL with the Preschool MSEL. It consists of a GrossMotor Scale and four Cognitive Scales: Visual Reception, Fine-Motor, Receptive Language, and Expressive Language. The Gross-Motor Scale is for use with children ages birth through 33 months, whereas the Cognitive Scales are used with children ages birth to 68 months. T-scores (mean of 50 and a standard deviation of 10) are given for individual scales, and an optional Early Learning Composite serves as an overall estimate of cognitive functioning. The Mullen Scales may be used for eligibility decisions as well as program planning.
Quality and safety in the transitional care of the elderly (phase 2): the study protocol of a quasi-experimental intervention study for a cross-level educational programme

Introduction Transitional care and patient handover are important areas to ensure quality and safety in elderly healthcare services. Previous studies showed that healthcare professionals have little knowledge of the setting they are transferring patients to and a limited understanding of roles and functions; these constitute barriers to effective communication and shared care responsibilities across levels of care. Aim The main objective is to implement a cross-level education-based intervention programme with healthcare professionals aimed at (1) increasing professionals’ awareness and competencies about quality and safety in the transitional care of the elderly; (2) creating a discussion platform for knowledge exchange and learning across levels and units of care and (3) improving patient safety culture, in particular, in transitional care. Methods and analysis A quasi-experimental control group study design with an intervention group and a control group; this includes a pretest, post-test and 1-year follow-up test assessment of patient safety culture. Qualitative data will be collected during the intervention programme and between the measurements. The study design will be beneficial for addressing the effects of the cross-level educational intervention programme on reports of patient safety culture and for addressing the feasibility of the intervention measures. Ethics and dissemination The study has been approved by the Regional Committees for Medical and Health Research Ethics in Norway, Ref. No. 2011/1978. The study is based on informed written consent; informants can withdraw from the study at any point in time. The results will be disseminated at research conferences, in peer review journals and through public presentations outside the scientific community.