Miracle-dz/UniFAR-FTUs huggingface dataset:
cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging

The ubiquitous second messenger 3′,5′-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques available for real-time cGMP measurements with a specific focus on live cell imaging methods. We will also discuss currently accepted and emerging mechanisms of cGMP compartmentation in the cardiovascular system.
CARCASS CHARACTERISTICS OF KANNIADU GOAT UNDER DIFFERENT SYSTEMS OF MANAGEMENT *

An experiment was conducted to evaluate the carcass characteristics of Kanniadu kids under different housing systems viz., intensive, semi-intensive and extensive system of rearing. Twenty-four weaned Kanniadu kids were selected at random and they were allotted to three different treatments, comprising of eight animals in each group. The dressing percentage of intensive and semiintensively reared kids was significantly (P < 0.05) higher than those reared under intensive system. The primal cuts percentage did not differ significantly for leg, rack, neck and shoulder, breast and shank between systems. There was a significant (P <0.01) difference between systems for the loin. The meat percentage in carcass did not differ significantly between systems. For the bone and fat, there was a highly significant (P < 0.01) difference between systems. Kids reared under extensive system produced lean meat compared to other systems without any significant difference in meat yield.
Searching for Context: a Study on Document-Level Labels for Translation Quality Estimation

In this paper we analyse the use of popular automatic machine translation evaluation metrics to provide labels for quality estimation at document and paragraph levels. We highlight crucial limitations of such metrics for this task, mainly the fact that they disregard the discourse structure of the texts. To better understand these limitations, we designed experiments with human annotators and proposed a way of quantifying differences in translation quality that can only be observed when sentences are judged in the context of entire documents or paragraphs. Our results indicate that the use of context can lead to more informative labels for quality annotation beyond sentence level.
Seasonal Variations in Physical Fitness and Performance Indices of Elite Soccer Players

The aim of the study was to investigate seasonal variations in fitness and performance indices of professional male soccer players. Eighteen professional male soccer players (age range 22–32 years) completed three similar sets of tests at three stages of the season: before preseason; after preseason and the middle of the competitive in-season. A significant decrease in body mass and percent fat was found during the preseason. A significant improvement (p < 0.05) was found in the vertical jump (preseason: 37.0 ± 5.3, post-preseason: 39.0 ± 4.8, mid-season: 40.3 ± 5.5 cm), the 4 × 10-m agility test (preseason: 8.1 ± 0.2, post-preseason: 7.9 ± 0.2, mid-season: 8.1 ± 0.3 s), flexibility (preseason: 45.2 ± 8.8, post-preseason: 48.2 ± 7.0, mid-season: 49.9 ± 6.9 cm) and aerobic capacity (preseason: 52.7 ± 6.6, post-preseason: 56.4 ± 6.0, mid-season: 57.4 ± 5.4 mL/kg/min) during preseason, with no further change during mid-season. Repeated sprint test (RST) (6 × 30-m) performance indices showed significant deterioration (p < 0.05) in ideal sprint time (IS; preseason: 21.8 ± 1.0, post-preseason: 23.0 ± 0.8, mid-season: 23.2 ± 0.8 s) and total sprint time (TS; preseason: 22.5 ± 0.7, post-preseason: 23.5 ± 0.6, mid-season: 23.8 ± 0.6 s) during preseason, with no further changes during mid-season. However, performance decrement (PD) significantly decreased during the preseason with no change during mid-season. The findings suggest that while power training was probably responsible for the anaerobic fitness improvement, the high-volume training led to improvement in aerobic fitness during the preseason. However, the low-intensity aerobic-type training, coupled with the high total training load, may have led to fatigue and decreases in IS and TS during the preseason.
Involvement of dysregulated coding and long non-coding RNAs in the pathogenesis of strabismus

Strabismus is a common ocular disorder in children and may result in exterior abnormalities and impaired visual functions. However, the detailed pathogenesis of strabismus unclear. The present study assessed the comprehensive analyses on the roles of RNAs in the development of strabismus. The public datasets of strabismus and the corresponding control tissues were downloaded from the Gene Expression Omnibus (GEO). Reannotations of the dysregulated coding and long non-coding RNAs (lncRNAs) and functional enrichments of the differently expressed genes (DEGs) were conducted. A total of 790 DEGs were screened (648 upregulated and 142 downregulated) in the present study. Among the DEGs, a total of 32 differently expressed lncRNAs were detected (14 upregulated and 18 downregulated). When the Gene Ontology (GO) enrichment was considered, it was identified that a total of 143 GO terms (82 for biological process, 31 for cellular component and 30 for molecular function) were identified. Among all the 57 detected Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, the phagosome pathway, which was labeled as hsa004145, demonstrated the most bioinformatics importance. However, most lncRNAs, except LINC01279 and LOC643733, indicated <3 target mRNAs and were not suitable for advanced bioinformatics analyses. Bioinformatics analyses demonstrated that there was a GO term for each lncRNA (proteinaceous extracellular for LINC01279 and cell surface for LOC643733). In conclusion, a set of coding RNA as well as lncRNAs differentially expressed in strabismus EOM samples were indicated. Notably, the present findings important information for advanced pathogenesis research and biomarkers detection.
A Preliminary Examination of Concussion Knowledge by Collegiate Athletes and Non-Athletes.

Purpose Concussions affect various populations, including collegiate athletes and non-athletes. The purpose of this study was to compare collegiate varsity athletes, recreational athletes, and non-athletes' knowledge of concussion definition, symptoms, and support services available following injury. Preferred method of concussion education delivery was also examined. Method We surveyed 306 current college students using an online survey system. The survey included free recall and forced-choice question formats. Quantitative analyses were used to analyze results and compare responses among groups. Results Collegiate athletes and non-athletes demonstrate incomplete knowledge of concussion definition, related symptoms, and professionals involved in postinjury management. Varsity athletes rated self-knowledge of concussion parameters significantly higher than the other groups (p < .001), though few significant differences in actual knowledge levels were observed. Overall, respondents reported having the highest preference for concussion education delivered by medical professionals. Conclusion Knowledge concerning concussion is incomplete in the collegiate population. Varsity athletes' exposure to formal education did not result in higher knowledge levels compared with other groups. Further examination of concussion educational delivery models' effect on change in concussion-related behavior in this population is warranted.
A three-microRNA signature as a diagnostic and prognostic marker in clear cell renal cancer: An In Silico analysis

Accumulating evidence has demonstrated that some specific miRNAs were aberrantly expressed in renal clear cell carcinoma and participated in many biological processes. The aim of this study was to investigate a panel of miRNA signature for diagnosis and prognosis of renal clear cell carcinoma (KIRC). Here, we performed a comprehensive analysis for miRNA expression profiles and corresponding clinical information of 516 KIRC patients from The Cancer Genome Atlas (TCGA). In the study, a total of 63 differentially expressed miRNAs were identified, of which 34 were up-regulated and 29 were down-regulated. We constructed a panel of three-miRNA that were significantly associated with KIRC diagnosis and KIRC patients' prognosis. The three-miRNA signature reached a sensitivity of 98.3% and a specificity of 97.2% in the diagnosis of KIRC. Using the three-miRNA signature, we classified the KIRC patients into high-risk group and low-risk group. The Kaplan- Meier curves showed that KIRC patients with high risk scores had significantly worsen overall survival (OS) and disease free survival (DFS) than KIRC patients with low risk scores. In the univariate and multivariate Cox regression analysis, three-miRNA signature was an independent prognostic factor in OS. In conclusion, the three-miRNA signature could be used as a diagnostic and prognostic biomarker in KIRC, and therefore, may help to provide significant clinical implication for the treatment of KIRC.
Perception of the importance of chemistry research papers and comparison to citation rates

Chemistry researchers are frequently evaluated on the perceived significance of their work with the citation count as the most commonly-used metric for gauging this property. Recent studies have called for a broader evaluation of significance that includes more nuanced bibliometrics as well as altmetrics to more completely evaluate scientific research. To better understand the relationship between metrics and peer judgements of significance in chemistry, we have conducted a survey of chemists to investigate their perceptions of previously published research. Focusing on a specific issue of the Journal of the American Chemical Society published in 2003, respondents were asked to select which articles they thought best matched importance and significance given several contexts: highest number of citations, most significant (subjectively defined), most likely to share among chemists, and most likely to share with a broader audience. The answers to the survey can be summed up in several observations. The ability of respondents to predict the citation counts of established research is markedly lower than the ability of those counts to be predicted by the h-index of the corresponding author of each article. This observation is conserved even when only considering responses from chemists whose expertise falls within the subdiscipline that best describes the work performed in an article. Respondents view both cited papers and significant papers differently than papers that should be shared with chemists. We conclude from our results that peer judgements of importance and significance differ from metrics-based measurements, and that chemists should work with bibliometricians to develop metrics that better capture the nuance of opinions on the importance of a given piece of research.
Adaptive tracking via pinning in networks of nonidentical nodes

We investigate the control of dynamical networks for the case of nodes, that although different, can be make passive by feedback. The so-called V-stability characterization allows for a simple set of stabilization conditions even in the case of nonidentical nodes. This is due to the fact that under V-stability characterization the dynamical diﬀerence between node of a network reduces to their diﬀerent passivity degrees, that is, a measure of the required feedback gain necessary to make the node stable at a desired solution. We propose a pinning control strategy that extends this approach to solve the tracking problem, furthermore using an adaptive controller approach we provide a methodology to impose a common reference trajectory to a network of diﬀerent nodes by pinning only a few of them to the desired solution. We illustrate our results with numerical simulation of well-known benchmark systems.
Glass fiber dissolution in a physiological saline solution

This report presents the results of a systematic study of glass fiber dissolution rate and mechanism for glasses in the SiO 2 -Al 2 O 3 -B 2 O 3 -CaO-MgO-BaO-Na 2 O system using glass fiber samples melted and formed in the laboratory to approximately the same uniform diameter
It's the Thought That Counts

Evidence from developmental psychology suggests that representing the contents of other people's thoughts and beliefs depends on a component of reasoning about other minds (theory of mind) that is distinct from the earlier-developing mental-state concepts for goals, perceptions, and feelings. To provide converging evidence, the current study investigated the substrate of the late-developing process in adult brains. Three regions—the right and left temporo-parietal junction and the posterior cingulate—responded selectively when subjects read about a protagonist's thoughts, but not when they read about other subjective, internal states or other socially relevant information about a person. By contrast, the medial prefrontal cortex responded equivalently in all of these story conditions, a result consistent with a broader role for medial prefrontal cortex in general social cognition. These data support the hypothesis that the early- and late-developing components of theory of mind rely on separate psychological and neural mechanisms, and that these mechanisms remain distinct into adulthood.
Fuel Effects on Homogeneous Charge Compression Ignition Combustion

Homogeneous charge compression ignition (HCCI) is one combustion strategy that has shown the possibility of both lower emissions and lower fuel consumption than spark ignition combustion. However, HCCI combustion can be sensitive to changes in fuel composition. The effects of fuel composition on HCCI combustion were experimentally investigated in a single cylinder 4-stroke SI engine adapted to run HCCI combustion with the Negative Valve Overlap (NVO) valve timing strategy. This strategy traps large amounts of hot residual gases in the cylinder to raise the mixture temperature and promote auto-ignition. Direct fuel injection was used, with one injection occurring during the NVO period to increase the residual temperature and for fuel reforming, and the other injection occurring just after intake valve opening. The timing and duration of the NVO injection were used to control the combustion phasing; an advance in timing or increase in delivered fuel mass caused an advance in combustion. The testing was performed at three operating conditions: 2100RPM 3bar IMEP, 2100RPM 2bar IMEP, and 3500RPM 2bar IMEP. Three gasoline-like fuels and an 87 octane pump gasoline were tested to examine the effects on fuel consumption and HC, CO, and NOx emissions. The trends for the fuels were consistent over all conditions and correlated well with combustion phasing. Most differences were small with a few exceptions. One of the test fuels, which was the only oxygenated fuel tested, showed significantly higher fuel consumption, which was mainly due to its lower energy density. This fuel also had lower HC emissions than the other test fuels; however, this may have been caused by the HC analyzer’s lower response to oxygenated hydrocarbons. The pump
An XML-based Tool for Tracking English Inclusions in German Text

The use of lexicons and corpora advances both linguistic research and performance of current natural language processing (NLP) systems. We present a tool that exploits such resources, specifically English and German lexical databases and the World Wide Web to recognise English inclusions in German newspaper articles. The output of the tool can assist lexical resource developers in monitoring changing patterns of English inclusion usage. The corpus used for the classification covers three different domains. We report the classification results and illustrate their value to linguistic and NLP research.
Effect of pre-heating composite resin on gap formation at three different temperatures

Aim: The study aims to evaluate and compare total gap surface area formed after restoration of class II cavities with Filtek Z350 and P60 at room temperature, 37°C and 54°C. Materials and Methods: Thirty extracted maxillary and mandibular molars were taken and divided into six groups of five teeth each. Standardized class II cavities were made and were restored with Filtek Z350 and P60, both at room temperature, 37°C and 54°C. Group 1(a) was restored with Filtek Z350 at room temperature, Group 1(b) with Filtek Z350 at 37°C and Group 1(c) with Filtek Z350 at 54°C. Group 2(a) was restored with P60 at room temperature, Group 2(b) with P60 at 37°C and Group 2(c) with P60 at 54°C. After storing the samples in distilled water at room temperature for 48 hours, longitudinal sectioning was done to obtain tooth restoration interface. The interfaces were then examined under compound light microscope with digital output and analyzed using Image J analysis software. Results: The results demonstrated better adaptation and less total gap area formation at 54°C as compared to room temperature and 37°C. Conclusions: Based on the results of this study, it is suggested that use of P60 is better suited for posterior restorations at 54°C as compared to Filtek Z350 universal nanohybrid at room temperature.
Gut microbial ecology of lizards: insights into diversity in the wild, effects of captivity, variation across gut regions and transmission

Animals maintain complex associations with a diverse microbiota living in their guts. Our understanding of the ecology of these associations is extremely limited in reptiles. Here, we report an in‐depth study into the microbial ecology of gut communities in three syntopic and viviparous lizard species (two omnivores: Liolaemus parvus and Liolaemus ruibali and an herbivore: Phymaturus williamsi). Using 16S rRNA gene sequencing to inventory various bacterial communities, we elucidate four major findings: (i) closely related lizard species harbour distinct gut bacterial microbiota that remain distinguishable in captivity; a considerable portion of gut bacterial diversity (39.1%) in nature overlap with that found on plant material, (ii) captivity changes bacterial community composition, although host‐specific communities are retained, (iii) faecal samples are largely representative of the hindgut bacterial community and thus represent acceptable sources for nondestructive sampling, and (iv) lizards born in captivity and separated from their mothers within 24 h shared 34.3% of their gut bacterial diversity with their mothers, suggestive of maternal or environmental transmission. Each of these findings represents the first time such a topic has been investigated in lizard hosts. Taken together, our findings provide a foundation for comparative analyses of the faecal and gastrointestinal microbiota of reptile hosts.
Product toxicity and cometabolic competitive inhibition modeling of chloroform and trichloroethylene transformation by methanotrophic resting cells

The rate and capacity for chloroform (CF) and trichloroethylene (TCE) transformation by a mixed methanotrophic culture of resting cells (no exogenous energy source) and formate-fed cells were measured. As reported previously for TCE, formate addition resulted in an increased CF transformation rate (0.35 day-1 for resting cells and 1.5 day-1 for formate-fed cells) and transformation capacity (0.0065 mg of CF per mg of cells for resting cells and 0.015 mg of CF per mg of cells for formate-fed cells), suggesting that depletion of energy stores affects transformation behavior. The observed finite transformation capacity, even with an exogenous energy source, suggests that toxicity was also a factor. CF transformation capacity was significantly lower than that for TCE, suggesting a greater toxicity from CF transformation. The toxicity of CF, TCE, and their transformation products to whole cells was evaluated by comparing the formate oxidation activity of acetylene-treated cells to that of non-acetylene-treated cells with and without prior exposure to CF or TCE. Acetylene arrests the activity of methane monooxygenase in CF and TCE oxidation without halting cell activity toward formate. Significantly diminished formate oxidation by cells exposed to either CR or TCE without acetylene compared with that with acetylene suggests that the solvents themselves were not toxic under the experimental conditions but their transformation products were. The concurrent transformation of CF and TCE by resting cells was measured, and results were compared with predictions from a competitive-inhibition cometabolic transformation model. The reasonable fit between model predictions and experimental observations was supportive of model assumptions.
PROFILE OF ACUTE MYOCARDIAL INFARCTION (AMI) IN PAKISTAN

Objective: While doing the study on Aspirin Awareness and Usage (AAUS) in cases of Acute Coronary Syndrome (ACS), AAUS study Group designed the protocol to include the profile of patients presenting with symptoms of ACS and in the light of that also reviewed the available data in South Asian population. Methodology: A prospective study was carried out in 17 coronary care units (CCUs) in all 4 provinces of Pakistan. Patients included were males and females of all age groups presenting with chest pain, diagnosed to have Coronary Artery Disease (CAD) and categorized into Unstable Angina (USA), STEMI or NSTEMI, based on clinical, ECG and enzymatic criteria. The risk factors, family history, dietary history, time to reach ER after the onset of symptoms, management of ACS in CCU and outcome of treatment were recorded. Results: A total of 1,527 patients presented to the Emergency Room (ER) with chest pain but around 1400 patients were evaluable. The majority (68%) were males. The mean age of all patients was 52.2±10.7 years. 28.3% patients were <45 years. Average time to presentation at ER was 13.2±6.2 hours. 92.7% patients presented with chest pain. More than half the patients had hypertension (55.2%) and or smoking (52%) as the risk factors while 37.2 % had diabetes and 18.2% had hyperlipidemia. Hypertension (52.7%), IHD (44%) and Diabetes (36.2%) figured prominently in the family history. USA and STEMI were the major types of ACS (43.0% and 40.5% respectively). At discharge 67.8% of patients were stable without symptoms, 13.3% were stable but with symptoms, 16.4% were referred for further investigations and 2.5% had died. Conclusions: The review of the available data in Pakistan, supported by the present study in a cohort of 1400 patients from 17 CCUs in the country, the emerging profile of patients with AMI is that the majority are male, relatively younger as compared to Western population, have smoking and hypertension followed by diabetes as the major risk factors. USA and STEMI are the dominant types of ACS and the majority of patients are likely to have hypertension, IHD and diabetes in their families. Better control of risk factors and the awareness of preventive strategies are needed.
Story representation in analogy-based story generation in Riu

Computational analogy offers a promising direction to algorithmically generating stories, a key challenge in computational narrative. Since analogy methods are very sensitive to the story representation being used, this paper focuses on story representation for analogy-based story generation. Specifically, we analyze existing story representation formalisms and propose a new approach based on the cognitive semantics theory of force dynamics. Finally, we present the results of our analogy-based interactive narrative system, Riu, to illustrate the utility of our proposal.