Miracle-dz/UniFAR-FTUs huggingface dataset:
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability

Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3/IMP3/KOC), initially identified as an RNA-binding protein, is highly expressed in embryonic tissues and a variety of cancers. Previously, our group reported that IGF2BP3 may serve as a potential diagnostic marker for lung cancer. However, little is known about the function of IGF2BP3 in lung cancer development. Here we demonstrate that IGF2BP3 expression was markedly increased in lung cancer tissues compared to normal tissues at both mRNA and protein levels. Overexpression of IGF2BP3 in lung cancer cells promoted cell proliferation, tumor migration and invasion in vitro and in vivo, whereas knockdown of IGF2BP3 exhibited opposite effects. Notably IGF2BP3 was directly associated with a deubiquitinase Ubiquitin specific peptidase 10 (USP10) and attenuated its function in stabilizing p53 protein. Silencing IGF2BP3 expression in lung cancer cells consistently increased the half-life and protein level of p53 and induced G0/G1 arrest. Thus, our data together demonstrate that IGF2BP3 promotes lung tumorigenesis via attenuating p53 protein stability.
Blood Magic: The Anthropology of Menstruation.

Examining cultures as diverse as long-house dwellers in North Borneo, African farmers, Welsh housewives, and postindustrial American workers, this volume dramatically redefines the anthropological study of menstrual customs. It challenges the widespread image of a universal 'menstrual taboo' as well as the common assumption of universal female subordination which underlies it. Contributing important new material and perspectives to our understanding of comparative gender politics and symbolism, it is of particular importance to those interested in anthropology, women's studies, religion, and comparative health systems.
Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease

The β2-adrenergic receptor (β2AR) is a seven-transmembrane (7TM) G-protein coupled receptor that is expressed on cells of the pulmonary, cardiac, skeletal muscle, and immune systems. Previous work has shown that stimulation of this receptor on immune cells has profound effects on the regulatory activity of both adaptive and innate immune cells. This review examines the functional dichotomy associated with stimulation of β2AR and microglial cells. As well, recent studies targeting these receptors with long-acting agonists are considered with respect to their therapeutic potential in management of Parkinsonμs disease.
Social class and pedagogy: a model for the investigation of pedagogic variation

This article addresses an enduring concern in the sociology of education: how social class differences are reproduced through schooling. In particular it focuses on the functioning of pedagogy in this regard. The article presents a model that elucidates the inner logic of pedagogy in order to reveal the structuring of inequality with respect to different groups of students. Theoretical concepts are drawn from the work of Bernstein, Dowling (1998) and Pedro (1981). An analysis considering the relay of social class differences, what is relayed, and its organizational form is undertaken with respect to working class and middle class children learning literacy in a sample of South African primary schools.
Implicit positive emotion counteracts ego depletion

Previous researchers have shown that individual acts of self-regulation deplete individual psychological resources, resulting in poor subsequent self-regulation and ego depletion. It has also been shown that to counteract ego depletion, besides getting enough sleep or rest, positive emotions are important. In this study we aimed to establish whether or not implicit positive emotion is important in countering ego depletion. In 2 experiments measuring the duration of self-regulation after implicit positive emotion it was found that self-regulation counteracts ego depletion. Participants in an ego-depleted condition were exposed to subliminal positive stimuli and they persisted in subsequent self-regulation longer than another group of participants who were exposed to subliminal neutral stimuli.
Financing Investment: The Choice between Bonds and Bank Loans

We build a model of investment and financing decisions to study the choice between bonds and bank loans in a firm's marginal financing decision and its effects on corporate investment. We show that firms with more growth options, with higher bargaining power in default, operating in more competitive product markets, or facing lower credit supply are more likely to issue bonds. We also demonstrate that, by changing the cost of financing, these characteristics affect the timing of investment. We test these predictions using a sample of U.S. firms and present new evidence that supports our theory. Data, as supplemental material, are available at http://dx.doi. org/10.1287/mnsc.2014. 2005 . This paper was accepted by Gustavo Manso, finance.
The H19 Differentially Methylated Region Marks the Parental Origin of a Heterologous Locus without Gametic DNA Methylation

ABSTRACT Igf2 and H19 are coordinately regulated imprinted genes physically linked on the distal end of mouse chromosome 7. Genetic analyses demonstrate that the differentially methylated region (DMR) upstream of the H19 gene is necessary for three distinct functions: transcriptional insulation of the maternal Igf2 allele, transcriptional silencing of paternal H19 allele, and marking of the parental origin of the two chromosomes. To test the sufficiency of the DMR for the third function, we inserted DMR at two heterologous positions in the genome, downstream of H19 and at the alpha-fetoprotein locus on chromosome 5. Our results demonstrate that the DMR alone is sufficient to act as a mark of parental origin. Moreover, this activity is not dependent on germ line differences in DMR methylation. Thus, the DMR can mark its parental origin by a mechanism independent of its own DNA methylation.
Comparing Vessel Trajectories Using Geographical Domain Knowledge and Alignments

This paper presents a similarity measure that combines low-level trajectory information with geographical domain knowledge to compare vessel trajectories. The similarity measure is largely based on alignment techniques. In a clustering experiment we show how the measure can be used to discover behavior concepts in vessel trajectory data that are dependent both on the low-level trajectories and the domain knowledge. We also apply this measure in a classification task to predict the type of vessel. In this task the combined measure performs better than similarities based on domain knowledge or low-level information alone.
Endometrial aromatase mRNA as a possible screening tool for advanced endometriosis and adenomyosis

Endometriosis (ENDs) and adenomyosis (ADNs) are estrogen-dependent diseases. The aim of this study was to determine the clinical usefulness of examining endometrial biopsy specimens for aromatase cytochrome P450 (CYP19) as a diagnostic importance for endometriosis and adenomyosis. In general, the RT-PCR analyses of 101 samples revealed increased aromatase mRNA expression in eutopic endometrium in women with endometriosis and adenomyosis compared to healthy controls (p = 0.0002). The highest number of positive cases (93.3%) of CYP19 mRNA expression was detected in women with advanced disease stages. Concrete expression of CYP19 mRNA level in controls was 0.68 compared to patients with ADNs (1.21), ENDsL stage I-II (1.15) and ENDsA stage III-IV (1.65) (p < 0.0001), respectively. The possible influence of increased body mass index on aromatase expression in each group showed in controls an insignificant slight increase of aromatase expression, contrary to cases where this trend was the opposite. The results point to the higher (2.45-fold) difference in aromatase expression in patients with endometriosis stage III-IV compared to controls and provide direct evidence that screening for eutopic endometrial aromatase expression in combination with clinical data could be of discriminative value in the prediction of estrogen-dependent diseases, independent from body mass index.
Co‐circulation of three pathogenic hantaviruses: Puumala, Dobrava, and Saaremaa in Hungary

Hantaviruses (Bunyaviridae) cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus (cardio)pulmonary syndrome (HCPS) in the Americas. HFRS is caused by Hantaan virus (HTNV), Seoul virus (SEOV), Dobrava virus (DOBV), Saaremaa virus (SAAV), and Puumala virus (PUUV). Of those, only HTNV is not present in Europe. In recent years, hantaviruses, described in other parts of Europe, were also detected at various locations in Hungary. To study the genetic properties of Hungarian hantaviruses in detail, sequences of the viral S and M segments were recovered from bank voles (Myodes glareolus), yellow‐necked mice (Apodemus flavicollis), and striped field mice (Apodemus agrarius) trapped in the Transdanubian region. As expected, the sequences recovered belonged, respectively, to PUUV (two strains), DOBV (one strain), and SAAV (one strain). On phylogenetic trees two new Hungarian PUUV strains located within the well‐ supported Alpe‐Adrian (ALAD) genetic lineage that included also Austrian, Slovenian, and Croatian strains. Analysis of the Hungarian SAAV and DOBV genetic variants showed host‐specific clustering and also geographical clustering within each of these hantavirus species. Hungarian SAAV and DOBV strains were related most closely to strains from Slovenia (Prekmurje region). This study confirms that multiple hantaviruses can co‐circulate in the same locality and can be maintained side‐by‐side in different rodent species. J. Med. Virol. 81:2045–2052, 2009. © 2009 Wiley‐Liss, Inc.
On the value of being American

The virtue of an American option is that it can be exercised at any time. This right is particularly valuable when there is model uncertainty. Yet almost all the extensive literature on American options assumes away model uncertainty. This paper quantifies the potential value of this flexibility by identifying the supremum on the price of an American option when no model is imposed on the data, but rather any model is required to be consistent with a family of European call prices. The bound is enforced by a hedging strategy involving these call options which is robust to model error.
The criteria for optimal down-regulation with gonadotropin-releasing hormone-agonist: a retrospective cohort study

Abstract Objective: The objective of this study is to investigate whether the degree of down-regulation using GnRH-agonists is associated with pregnancy outcomes. Study design: This retrospective analysis was performed on 2708 cycles from 2514 patients undergoing down-regulation with the luteal phase long protocol. The serum oestradiol (E2D) and luteinising hormone (LHD) levels, the diameter of the largest follicle (DLFD) and the endometrial-thickness (ENTD) after down-regulation were used to evaluate the degree of down-regulation. One-way analysis of variance with the Bonferroni adjustment, the chi-square test and multivariate logistic regression analyses were used for the statistical analysis. Results: The cumulative clinical pregnancy rates (CCPR) and the cumulative live birth rates (CLBR) were higher in the cycles with E2D < 30 pg/ml (63.7%, OR = 1.405 (1.055–1.870) and 56.8%, OR = 1.372 (1.039–1.813)) and 30–55pg/ml (66.8%, OR = 1.439 (1.104–1.874) and 59.8%, OR = 1.397 (1.080–1.806)) than in those with E2D > 55 pg/ml (62.8% and 54.7%). There was a trend towards lower CCPRs and CLBRs in the cycles with DLFD > 10 mm or ENTD ≥ 6 mm; however, this difference was not significant. Conclusion: The degree of down-regulation is associated with ovarian response, pregnancy, and live birth. We propose the following criteria for optimal down-regulation: E2D 30-55 pg/ml, ENTD < 6 mm, and no apparent ovarian activity.
An Exploratory Study of the Emotion-Expressive Behaviors of “Peace,” “Contentment,” and “Annoyed/Irritated”: Implications for Dead and Living Faces

This study initially set out to explore the facial features (and their descriptions) of the emotion-expressive behaviors of “peace” and “contentment” but ended up with a third one, “annoyed/irritated. ” The emotion-expressive behaviors of “peace” and “contentment” have been associated with the faces of deceased persons in a previous study. The pictures of two volunteers taken during a class on relaxation technique were given to 93 respondents made up of volunteer students from a small midwestern college and volunteer residents of a nursing home (see Appendix A and B). Participants were asked to choose from a list provided them the emotion-expressive behavior (“e.g., peace, content, hopeful, other”) that closely described each of the facial pictures presented. They were also asked to both identify and describe the facial feature(s) that closely matched the emotion-expressive behavior they had chosen. Most of the respondents identified Picture #1 as “peaceful” and Picture 2 as “annoyed/irritated. ” The eyes and the mouth were more salient in describing both emotions. This study has implications for those who identify loved ones before viewing; for individuals who prepare deceased persons for viewing; for embalming educators; and for actors of these emotions.
Factors That Contribute to Economic Well-Being in Female-Headed Households

ABSTRACT This study assesses factors associated with female heads of households maintaining income levels above 100% of the federal poverty threshold. All women in the sample are single, divorced, separated or widowed, with children in the home, and none on public assistance. The data for the study are from the National Survey of Families and Households (NSFH), with a sample size of 670. The dependent variable, a dichotomous measure of whether the female head has an income over 100% of the federal poverty level, is regressed on human capital, assets, and child support variables using logistic regression analysis. Women with higher education, greater number of weeks worked in the previous year, more money in a savings account and who owned a car were all significantly more likely to have incomes above 100% of the federal poverty level. Child support payments were not significant in determining poverty level. The implications of these findings are discussed in light of current economic and political uncerta.
Linear Feature Detection in Polarimetric SAR Images

Recently, the use of linear features for processing remote-sensing images has shown its importance in applications. Unfortunately, traditional linear feature detection methods rely heavily on the image's local information which makes them vulnerable to the presence of noise in the image. This problem becomes particularly difficult for synthetic aperture radar (SAR) image applications where SAR images are corrupted by speckle noise. In order to overcome this problem, we propose a novel method that processes the polarimetric synthetic aperture radar (Pol-SAR) images by combining the multiscale image analysis with polarimetric information in a new fashion. A two-scale approach is adopted here. On a coarse level, the coarse regions of the linear features are extracted by a curvelet transform from a speckle noise reduced image obtained by the polarimetric whitening filter. On a fine level, we develop a fuzzy polarimetric detector to accurately locate the linear features inside the regions. The effectiveness of the proposed method is demonstrated using simulated Pol-SAR data acquired from both EMISAR and Convair-580 systems.
Communication to Language: Deaf Children’s and Hearing Children’s Development Compared

Videotaped interaction of six children between 8 and 24 months old, some deaf (in an American Sign Language or Italian Sign Language environment), others hearing (in an English or Italian speaking environment), when analyzed, shows quite comparable stages and sequences of communicative development: the use of performative gestures or single vocalizations for general reference to situations precedes the use of referential gestures, signs, and words; and use of the latter precedes the combination of elements (signs, referential gestures, words); finally signs are combined with signs or words are combined with words, depending on the language to which the child is exposed.
Studies on Morphological Transformation of BALB/3T3-Derived Clones by Murine Leukemia Virus

We have described a cell line, UC1-B, derived spontaneously from BALB/3T3 mouse embryo cells, which, unlike the standard BALB/3T3, are morphologically transformed and produce bizarre viral forms in response to murine leukemia virus. Although UC1-B and BALB/3T3 are morphologically similar, and both form contact-inhibited monolayers at confluence, the UC1-B cells are partially transformed because: they grow to a slightly higher saturation density than 3T3 cells, they grow in medium lacking serum growth factors, and they produce tumors in mice. Another clone, 12A-3, derived from BALB/3T3, also transforms and produces bizarre viral forms after infection with murine leukemia virus. Unlike UC1-B cells, the 12A3-8 cells are identical in growth properties to BALB/3T3; therefore, a partially altered morphology is not required for the induction of transformation by murine leukemia virus.
THE COST OF BEING BLACK: White Americans' Perceptions and the Question of Reparations

White Americans have long resisted the idea of reparations to the descendants of slaves. We examine the psychological basis of such resistance, primarily testing the possibility that resistance may be a function of Whites' perception of the ongoing cost of being Black. White participants (n = 958) across twelve independent samples (varying in age, student status, and geographic location) were asked variations of the question: How much should you be paid to continue to live the remainder of your life as a Black person? Participants generally required low median amounts, less than $10,000, to make the race change, whereas they requested high amounts, $1,000,000, to give up television. To the extent that larger amounts were requested, support for reparations also increased. Attempts to educate participants about Black cost/White privilege had negligible effects on assessments of the cost of being Black and support for reparations. Together, these results suggest that White resistance to reparations for Black Americans stems from fundamental biases in estimating the true cost of being Black. The implications of our findings for color-blind and multiculturalist conceptual approaches are discussed.This work was facilitated by a postdoctoral fellowship to the first author from the Kirwan Institute for the Study of Race and Ethnicity at Ohio State University. In addition, we are greatly indebted to Hal Arkes for comments on an earlier draft of this manuscript.
The effects of multidimensional home-based exercise on functional performance in elderly people.

BACKGROUND This study tested the hypothesis that a home-based exercise program would improve functional performance in elderly people. METHODS We conducted a 6-month, single-blinded, randomized controlled trial. 72 community dwelling men and women (aged >/=70 years) with self-reported and laboratory-based functional impairment were recruited for the study. Participants were randomly assigned to either a home-based progressive strength, balance, and general physical activity intervention or an attention-control group that received home-based nutrition education. Functional performance was measured in the laboratory using the Physical Performance Test (PPT) and the Established Populations for Epidemiologic Studies of the Elderly (EPESE) short physical performance battery. Physiologic capacity was measured by strength (one repetition maximum), dynamic balance (tandem walk), gait speed (2-meter walk), and cardiovascular endurance (6-minute walk). RESULTS 70 participants (97%) completed the 6-month trial. Compliance with study interventions within each group ranged from 75% in controls to 82% in exercisers. PPT increased by 6.1 +/- 13.4% in exercisers and decreased by 2.8 +/- 13.6% in controls (p =.02). EPESE improved by 26.2 +/- 37.5% in exercisers and decreased by 1.2 +/- 22.1% in controls (p =.001). Dynamic balance improved by 33.8 +/- 14.4% in exercisers versus 11.5 +/- 23.7% in controls (p =.0002). There were no differences between groups in the change in strength, gait speed, or cardiovascular endurance. CONCLUSIONS Minimally supervised exercise is safe and can improve functional performance in elderly individuals. The improvements in functional performance occurred along with improvements in balance but without a significant change in muscle strength or endurance.
Cynicism among police chiefs

This paper examines the cynicism of police chiefs. Data were derived from the questionnaire responses of 519 of 771 Illinois police administrators (67.3 percent). The results indicate that cynicism among chiefs gradually declines with experience in office. In addition, chiefs with more education and those administering larger police agencies were found to experience less cynicism. However, we also found that there is little variance in police chief cynicism scores and that the mean cynicism score of chiefs is modest. Thus, the conclusion that police chiefs are not a cynical lot seems warranted.
Characterization of Mitochondrial and Extra-mitochondrial Oxygen Consuming Reactions in Human Hematopoietic Stem Cells

This study was aimed to characterize the mitochondrial and extra-mitochondrial oxygen consuming reactions in human CD34+ hematopoietic stem cells. Cell samples were collected by apheresis following pre-conditioning by granulocyte colony-stimulating factor and isolated by anti-CD34 positive immunoselection. Polarographic analysis of the CN-sensitive endogenous cell respiration revealed a low mitochondrial oxygen consumption rate. Differential absorbance spectrometry on whole cell lysate and two-dimensional blue native-PAGE analysis of mitoplast proteins confirmed a low amount of mitochondrial respiratory chain complexes thus qualifying the hematopoietic stem cell as a poor oxidative phosphorylating cell type. Confocal microscopy imaging showed, however, that the intracellular content of mitochondria was not homogeneously distributed in the CD34+ hematopoietic stem cell sample displaying a clear inverse correlation of their density with the expression of the CD34 commitment marker. About half of the endogenous oxygen consumption was extra-mitochondrial and completely inhibitable by enzymatic scavengers of reactive oxygen species and by diphenylene iodinium. By spectral analysis, flow cytometry, reverse transcriptase-PCR, immunocytochemistry, and immunoprecipitation it was shown that the extra-mitochondrial oxygen consumption was contributed by the NOX2 and NOX4 isoforms of the \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{O}_{2}^{{\bar{{\cdot}}}}\) \end{document}. producer plasma membrane NAD(P)H oxidase with low constitutive activity. A model is proposed suggesting for the NAD(P)H oxidase a role of O2 sensor and/or ROS source serving as redox messengers in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells.