Miracle-dz/UniFAR-FTUs huggingface dataset:
DISTRIBUTION STATEMENT A Approved for Public Release Distribution Unlimited A Scalable Solution to the Multi-Resource QoS Problem

The problem of maximizing system utility by allocating a single finite resource to satisfy discrete Quality of Service (QoS) requirements of multiple applications along multiple QoS dimensions was studied in [6]. In this paper, we consider the more complex problem of apportioning multiple finite resources to satisfy the QoS needs of multiple applications along multiple QoS dimensions. In other words, each application, such as video-conferencing, needs multiple resources to satisfy its QoS requirements. We evaluate and compare three strategies to solve this provably NP-hard problem. We show that dynamic programming and mixed integer programming compute optimal solutions to this problem but exhibits very high running times. We then adapt the mixed integer programming problem to yield near-optimal results with smaller running times. Finally, we present an approximation algorithm based on a local search technique that is less than 5% away from the optimal solution but which is more than two orders of magnitude faster. Perhaps more significantly, the local search technique turns out to be very scalable and robust as the number of resources required by each application increases. This work was supported in part by the Defense Advanced Research Projects Agency under agreements N6600197-C-8527 and E30602-97-2-0287, The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied of the Defense Advanced Research Projects Agency or the U.S. government. MIC QUALITY INSPECTED 4
White Matter Loss in a Mouse Model of Periventricular Leukomalacia Is Rescued by Trophic Factors

Periventricular leukomalacia (PVL) is the most frequent cause of cerebral palsy and other intellectual disabilities, and currently there is no treatment. In PVL, glutamate excitotoxicity (GME) leads to abnormal oligodendrocytes (OLs), myelin deficiency, and ventriculomegaly. We have previously identified that the combination of transferrin and insulin growth factors (TSC1) promotes endogenous OL regeneration and remyelination in the postnatal and adult rodent brain. Here, we produced a periventricular white matter lesion with a single intracerebral injection of N-methyl-d-aspartate (NMDA). Comparing lesions produced by NMDA alone and those produced by NMDA + TSC1 we found that: NMDA affected survival and reduced migration of OL progenitors (OLPs). In contrast, mice injected with NMDA + TSC1 proliferated twice as much indicating that TSC1 supported regeneration of the OLP population after the insult. Olig2-mRNA expression showed 52% OLP survival in mice receiving a NMDA injection and increased to 78% when TSC1 + NMDA were injected simultaneously and ventricular size was reduced by TSC1. Furthermore, in striatal slices TSC1 reduced the inward currents induced by NMDA in medium-sized spiny neurons, demonstrating neuroprotection. Thus, white matter loss after excitotoxicity can be partially rescued as TSC1 conferred neuroprotection to preexisting OLP and regeneration via OLP proliferation. Furthermore, we showed that early TSC1 administration maximizes neuroprotection.
Replicability and Reproducibility in Comparative Psychology

Psychology faces a replication crisis. The Reproducibility Project: Psychology sought to replicate the effects of 100 psychology studies. Though 97% of the original studies produced statistically significant results, only 36% of the replication studies did so (Open Science Collaboration, 2015). This inability to replicate previously published results, however, is not limited to psychology (Ioannidis, 2005). Replication projects in medicine (Prinz et al., 2011) and behavioral economics (Camerer et al., 2016) resulted in replication rates of 25 and 61%, respectively, and analyses in genetics (Munafò, 2009) and neuroscience (Button et al., 2013) question the validity of studies in those fields. Science, in general, is reckoning with challenges in one of its basic tenets: replication. Comparative psychology also faces the grand challenge of producing replicable research. Though social psychology has born the brunt of most of the critique regarding failed replications, comparative psychology suffers from some of the same problems faced by social psychology (e.g., small sample sizes). Yet, comparative psychology follows the methods of cognitive psychology by often using within-subjects designs, which may buffer it from replicability problems (Open Science Collaboration, 2015). In this Grand Challenge article, I explore the shared and unique challenges of and potential solutions for replication and reproducibility in comparative psychology.
Gender Differences in Questions Asked During Small Decision-Making Group Discussions

Sixty minutes each of group discussions from 18 four- to seven-member decision-making groups were audiotaped and transcribed for analysis. Results indicated that questions constituted 15.6% of total turns by group members. Probes were the most frequently occurring question type (89.2%). There was a significant gender difference in only one of the five question types: Female group members asked significantly more probing questions than did their male counterparts. Implications of these findings are discussed.
Throughput Analysis of WiMAX Based Wireless Networks

In this study, we derive an analytical model that determines the conditions that lead to throughput-starvation in Wimax-based networks. We limit our discussion to downlink traffic in point-to-multipoint (PMP) based networks. The objective of our model is to define the probability of a subscriber station becoming throughput starved under different operating conditions. The model also defines the probability of a subscriber station being throughput overserved under the same operating conditions. We validate the resulting model using simulation experiments.
Terrestrial exospheric hydrogen density distributions under solar minimum and solar maximum conditions observed by the TWINS stereo mission

Circumterrestrial Lyman-α column brightness observations above 3 Earth radii ( R e ) have been used to derive separate 3-D neutral hydrogen density models of the Earth's exosphere for solar minimum (2008, 2010) and near-solar-maximum (2012) conditions. The data used were measured by Lyman-α detectors (LAD1/2) onboard each of the TWINS satellites from very different orbital positions with respect to the exosphere. Exospheric H atoms resonantly scatter the near-line-center solar Lyman-α flux at 121.6 nm. Assuming optically thin conditions above 3 R e along a line of sight (LOS), the scattered LOS-column intensity is proportional to the LOS H-column density. We found significant differences in the density distribution of the terrestrial exosphere under different solar conditions. Under solar maximum conditions we found higher H densities and a larger spatial extension compared to solar minimum. After a continuous, 2-month decrease in (27 day averaged) solar activity, significantly lower densities were found. Differences in shape and orientation of the exosphere under different solar conditions exist. Above 3 R e , independent of solar activity, increased H densities appear on the Earth's nightside shifted towards dawn. With increasing distance (as measured at 8 R e ) this feature is shifted westward/duskward by between −4 and −5° with respect to midnight. Thus, at larger geocentric distance the exosphere seems to be aligned with the aberrated Earth–solar-wind line, defined by the solar wind velocity and the orbital velocity of the Earth. The results presented in this paper are valid for geocentric distances between 3 and 8 R e .
Self-Construals, Motivation, and Feedback-Seeking Behaviors

The current study explores the relations between individualism, motivation, and feedback-seeking behaviors. Specifically, we examined how three motivational factors (i.e., status-striving, achievement-striving, and affiliation-striving) mediated or moderated the relations between individualism and feedback-seeking behaviors. Data were collected from 154 Singaporean undergraduate students across two time periods. Results indicated that only status motivation mediates the individualism–feedback-seeking relation. Affiliation was found to moderate that same relation but only for a specific subset of feedback-seeking behaviors. The implications of these findings for performance management and development are discussed.
Coaching Efficacy and Volunteer Youth Sport Coaches

The Coaching Efficacy Scale (CES) measures beliefs coaches have to affect the learning and performance of their athletes. While previous research has provided support for the model of coaching efficacy and the CES as an adequate measure of the construct, these studies have used paid high-school and college coaches. It is possible that the factor structure of the CES may not replicate for volunteer youth sport coaches. The purpose of this study was to explore coaching efficacy sources used by volunteer youth sport coaches. In addition, the validity of the CES was examined, using a 5-point condensed rating scale, among volunteer youth sport coaches before exploring the sources. The study involved 492 volunteer youth sport coaches from various team sports. Confirmatory factor analysis indicated that the CES had an acceptable fit to the data. The sources of coaching efficacy were examined via multivariate multiple regression and canonical correlation. Results indicated that more confident coaches had more ext.
Decreased Level of IgE is Associated with Breast Cancer and Allergic Diseases

Background The aim of this study was to explore the prevalence of type I allergic diseases in patients with breast cancer by carrying out a questionnaire survey and IgE detection in a healthy population and in patients with breast cancer. Material/Method There were 309 patients enrolled and they were further divided into the type I allergic disease group, the newly diagnosed breast cancer with type I allergic disease group, the re-visit breast cancer with type I allergic disease group, and the re-visit breast cancer without type I allergic disease group, as well as a healthy control group. Serum total IgE level was detected by immunoassay. Results The IgE value in the healthy population with type I allergic diseases (89.3±51.4 IU/ml) was significantly higher than in those without type I allergic diseases (45.6±65.1 IU/ml). There was no significant difference between IgE values in the re-visit breast cancer patients with type I allergic disease (25.1±65.1 IU/ml) and those without type I allergic disease (23.0±45.9 IU/ml). The area under the ROC curve was 0.618±0.04, sensitivity was 78%, specificity was 47.1%, Youden index was 0.251, and IgE threshold was 32.6 IU/ml. Conclusions The patients with newly diagnosed breast cancer were susceptible to type I allergic disease at about the same levels as in the healthy population. There was no correlation between breast cancer and type I allergic disease.
Post-exercise coincidence anticipation in expert and novice Gaelic games players: the effects of exercise intensity

Abstract Within the current scientific literature, there is a distinct lack of empirical data examining the effects of exercise intensity on coincidence anticipation and, to date, no study has examined this in Gaelic games. Furthermore, many previous studies failed to consider fully sport specificity. The aims of this study were to examine the effect of moderate- and high-intensity exercise on coincidence anticipation and to determine whether post-exercise changes in coincidence anticipation were the same in novice and expert Gaelic games players (hurlers). Eleven expert and nine novice hurlers participated in this study. After familiarization, coincidence anticipation was measured using the Bassin Anticipation Timer at rest, following moderate- and high-intensity exercise. Exercise intensities were set using an incremental running protocol until the participants reached steady-state 70% and 90% heart rate reserve. To simulate hitting a ball, participants swung or “pulled” using a continuous swing at full speed with a standard hurley through a photoelectric beam as close to the actual arrival time of the stimulus at the target location as possible. Immediately following each exercise condition, participants performed 20 anticipation trials. All testing was randomized and counterbalanced. Raw scores were transformed to three error scores – constant error, absolute error, and log variable error. The effect of exercise intensity on constant error, absolute error, and log variable error was analysed using separate 3 (exercise intensities)×20 (trials)×2 (levels of skill) repeated-measures analyses of variance. The results showed no between- or within-group differences for constant error (P>0.05). For both absolute error and log variable error there were highly significant between-group differences (both P<0.01), which indicated that the expert hurlers at all exercise intensities exhibited significantly better coincidence anticipation than novice players probably due to experience among other factors. Further within-group analyses showed no differences in the expert players’ performance across exercise intensities. However, within-group analyses on the novice players’ data showed a significant difference between performance at rest and performance following moderate-intensity exercise. The results suggest that expert players are capable of maintaining coincidence anticipation performance across exercise intensities but the novice players performed optimally following moderate-intensity exercise.
Mindful Parenting Decreases Aggression, Noncompliance, and Self-Injury in Children With Autism

Parent—child transactions provide an important social context for the development of adaptive and problem behaviors in young children with autism.Teaching parents to develop alternative transactional pathways often leads to positive behavioral patterns in their children.We taught three parents the philosophy and practice of mindfulness in a 12-week course and assessed the outcome of the training on their children's behavior. In addition, the mothers rated satisfaction with their parenting skills and interactions with their children. Results showed that the mothers' mindful parenting decreased their children's aggression, noncompliance, and self-injury and increased the mothers' satisfaction with their parenting skills and interactions with their children.We speculated on the possible reasons for the efficacy of mindful parenting in decreasing the children's problem behaviors without the application of specific, programmed contingencies for the children's behavior.
Stimulus Complexity and Categorical Effects in Human Auditory Cortex: An Activation Likelihood Estimation Meta-Analysis

Investigations of the functional organization of human auditory cortex typically examine responses to different sound categories. An alternative approach is to characterize sounds with respect to their amount of variation in the time and frequency domains (i.e., spectral and temporal complexity). Although the vast majority of published studies examine contrasts between discrete sound categories, an alternative complexity-based taxonomy can be evaluated through meta-analysis. In a quantitative meta-analysis of 58 auditory neuroimaging studies, we examined the evidence supporting current models of functional specialization for auditory processing using grouping criteria based on either categories or spectro-temporal complexity. Consistent with current models, analyses based on typical sound categories revealed hierarchical auditory organization and left-lateralized responses to speech sounds, with high speech sensitivity in the left anterior superior temporal cortex. Classification of contrasts based on spectro-temporal complexity, on the other hand, revealed a striking within-hemisphere dissociation in which caudo-lateral temporal regions in auditory cortex showed greater sensitivity to spectral changes, while anterior superior temporal cortical areas were more sensitive to temporal variation, consistent with recent findings in animal models. The meta-analysis thus suggests that spectro-temporal acoustic complexity represents a useful alternative taxonomy to investigate the functional organization of human auditory cortex.
Pathway of γ-Aminobutyrate Metabolism in Rhizobium leguminosarum 3841 and Its Role in Symbiosis

ABSTRACT Pea plants incubated in 15N2 rapidly accumulated labeled γ-aminobutyrate (GABA) in the plant cytosol and in bacteroids of Rhizobium leguminosarum bv. viciae 3841. Two pathways of GABA metabolism were identified in R. leguminosarum 3841. In the first, glutamate is formed by GABA aminotransferase (GabT), transferring the amino group from GABA to 2-oxoglutarate. In the second, alanine is formed by two ω-aminotransferases (OpaA and OpaB), transferring the amino group from GABA to pyruvate. While the gabT mutant and the gabT opaA double mutant grew on GABA as a nitrogen source, the final triple mutant did not. The semialdehyde released from GABA by transamination is oxidized by succinate semialdehyde dehydrogenase (GabD). Five of six potential GabD proteins in R. leguminosarum bv. viciae 3841 (GabD1, -D2, -D3, -D4, and -D5) were shown by expression analysis to have this activity. However, only mutations of GabD1, GabD2, and GabD4 were required to prevent utilization of GABA as the sole nitrogen source in culture. The specific enzyme activities of GabT, Opa, and GabD were highly elevated in bacteroids relative to cultured bacteria. This was due to elevated expression of gabT, opaA, gabD1, and gabD2 in nodules. Strains mutated in aminotransferase and succinate semialdehyde dehydrogenases (gabT, opaA, or opaB and gabD1, gabD2, or gabD4, respectively) that cannot use GABA in culture still fixed nitrogen on plants. While GABA catabolism alone is not essential for N2 fixation in bacteroids, it may have a role in energy generation and in bypassing the decarboxylating arm of the tricarboxylic acid cycle.
Safety of Using Matrix Metalloproteinase Inhibitor in Experimental Glaucoma Filtration Surgery

We evaluated the safety of matrix metalloproteinase (MMP) inhibitor in experimental glaucoma filtration surgery in an animal model. Fifteen New Zealand white rabbits underwent an experimental trabeculectomy and were randomly allocated into 3 groups according to the adjuvant agent: no treatment group (n = 5), 0.02% mitomycin C (MMC) soaking group (n = 5), and MMP inhibitor (ilomastat) subconjunctival injection group (n = 5). Slit lamp examination with Seidel testing, pachymetry, and specular microscopy was performed preoperatively and postoperatively. The conjunctiva and ciliary body toxicity were evaluated with scores according to the pathologic grading systems. Electron microscopy was used to examine the structural changes in cornea, conjunctiva, and ciliary body. In the ilomastat-treated group, there was no statistically significant change in central corneal thickness preoperatively and at 28 days postoperatively (P = 0.655). There were also no significant changes in specular microscopy findings over the duration of the study in the ilomastat-treated group. The conjunctival toxicity score was 1 in the control group, 1.5 in the ilomastat-treated group, and 2 in the MMC-treated group. When assessing ciliary body toxicity scores, the ilomastat-treated group score was 0.5 and the MMC-treated group score was 1.5. Transmission electron microscopy did not show structural changes in the cornea and ciliary body whereas the structural changes were noticed in MMC group. A single subconjunctival injection of MMP inhibitor during the experimental trabeculectomy showed a less toxic affect in the rabbit cornea, conjunctiva, and ciliary body compared to MMC.
Sexual exchanges and relationship satisfaction: Testing the role of sexual satisfaction as a mediator and gender as a moderator

We surveyed 499 young, single adult heterosexuals in order to test a social exchange-based model where sexual satisfaction mediated the association between individuals' judgments about their sexually-related exchanges and their relationship satisfaction. Path analysis, using structural equation modeling, supported the hypothesized model. Moreover, invariance tests revealed that gender moderated the model. The association between balance of sexual rewards to costs and sexual satisfaction was stronger for single women as compared to single men. The discussion explores the implications of the model and role of gender as a moderator.
Applying Pleck's model of paternal involvement to the study of preschool attachment quality: a proof of concept study

Recent re-conceptualisation of paternal involvement (Pleck, J. H. (2010). Paternal involvement: Revised conceptualization and theoretical linkages with child outcomes. In M. Lamb (Ed.), The role of the father in child development (5th ed., pp. 67–107). London: Wiley), while proving fruitful, has yet to be applied to investigations into what extent a father's level of involvement may affect child–peer interactions in the preschool age range, over and above the effects of mother–child attachment quality and socio-economic status (SES). Patterns of associations between attachment quality, sensitivity and general caregiving behaviours have also yet to be compared in equally involved mothers and fathers. Thirty preschool children (17 males:13 females) with similar SES profiles and their immediate caregivers participated in hour-long observations, conducted in the home. Even when attachment quality was controlled for, children with low paternal involvement were found to have higher levels of child–peer aggression. Further, patterns of effects between caregiver sensitivity, child–caregiver attachment quality and general caregiver interactions were similar for equally involved mothers and fathers. These preliminary data support the concept of applying Pleck's (2010) re-conceptualisation of paternal involvement to preschool attachment, and have implications towards the wider study of child–father attachment. Limitations of the current study and directions for future research are discussed.
Concerns regarding the Traditional Paradigm for Causal Research: The Unified Paradigm and Causal Research in Scientific Psychology

The traditional paradigm refers to the assumption held by most methodologists and researchers that causal research must be defined in terms of the causal powers evident in a closed system. The traditional paradigm does not concord, however, with the nature of scientific theories often cited in the methodological and research literature. The unified paradigm is introduced and causal research defined in terms of the causal powers evident in an open system. Notable implications of the unified paradigm are that experimental methods do not provide a better opportunity than modeling methods to conduct a causal analysis and that the nomenclature often used to describe the validity of causal conclusions must be amended. Additional implications of the unified paradigm are discussed and includes a comparison of the traditional paradigm and the unified paradigm when applied to treatment-outcome research.