Miracle-dz/UniFAR-FTUs huggingface dataset:
Concomitant 177Lu-DOTATATE and Capecitabine Therapy in Patients With Advanced Neuroendocrine Tumors: A Long-term-Outcome, Toxicity, Survival, and Quality-of-Life Study

Purpose The purpose of this study was to evaluate the outcome, toxicity, survival, and quality of life in patients with advanced neuroendocrine tumors. Methods One hundred sixty-seven patients were enrolled in the study. All patients underwent baseline 68Ga-DOTANOC PET/CT scans. 177Lu-DOTATATE therapy was administered quarterly along with oral capecitabine therapy in group 1 patients (n = 88), whereas group 2 patients (n = 79) were treated only with 177Lu-DOTATATE. Hematologic, kidney function, liver function tests and chromogranin A levels were recorded before and after therapy at 2-week, 4-week, and 3-month intervals. Biochemical and morphological responses were assessed with the trend in chromogranin A levels and Response Evaluation Criteria in Solid Tumors 1.1 criteria, respectively. Results There was no significant difference in the hemoglobin levels after 177Lu-DOTATATE therapy (P = 0.4892). In most patients, there was a decrease in the platelet levels; however, all the patients had platelet counts greater than 100,000/&mgr;L with no platelet toxicity. There was no toxicity related to leukocytes. Two patients showed renal insufficiencies. No hepatotoxicity was observed in any of the patients. According to Response Evaluation Criteria in Solid Tumors 1.1 criteria, in group 1 patients, the response was partial response in 34% of the patients, stable disease in 50.2%, and progressive disease in 6.8% versus partial response in 6.3%, stable disease in 60.9%, and progressive disease in 26.5% among group 2 patients. The median overall survival (OS) and progression-free survival (PFS) was not reached in group 1 patients. The median OS and PFS in group 2 patients were 48 months. Ki-67 tumor proliferation index was significantly associated with increased risk of disease progression. Conclusions Addition of capecitabine therapy with 177Lu-DOTATATE therapy lengthens the OS and PFS. Patients with aggressive disease may benefit from this synergetic therapeutic approach.
Death, burial and bereavement amongst Bengali Muslims in Tower Hamlets, East London

Abstract This article discusses the circumstances surrounding death and bereavement amongst Bengali families in East London. Based on fieldwork amongst Bengali elders in the Spitalfields area the article suggests that death and some of the rituals surrounding it are rapidly moving from the private to the public domain within Britain. Whilst ‘traditionally’ in Sylhet most deaths involve the mobilisation of locally based social networks for support and ritual, material and social factors mean that in London death often takes place within hospitals and hospices rather than homes. Combined with this, rituals of bereavement are often carried out in Bangladesh, where bodies are returned for burial. This can mean that some members of the family, especially widows who do not usually accompany their husbands’ bodies to Sylhet, are excluded from important processes of ritual grieving. Many widows are also far more socially isolated in Britain than Stereotypic images of Bengali extended families might suggest. The s.
Volume preserving mean curvature flow in the Hyperbolic space

We prove: "If $M$ is a compact hypersurface of the hyperbolic space, convex by horospheres and evolving by the volume preserving mean curvature flow, then it flows for all time, convexity by horospheres is preserved and the flow converges, exponentially, to a geodesic sphere". In addition, we show that the same conclusions about long time existence and convergence hold if $M$ is not convex by horospheres but it is close enough to a geodesic sphere.
The pathogenesis of pseudorabies in mice following peripheral inoculation.

Summary Three-week-old mice were inoculated with pseudorabies virus by means of the left hind foot pad. Infectious virus was isolated from tissues in the sequence: foot pad, sciatic nerve and dorsal root ganglion, lower, middle, upper spinal cord, and brain. Virus was recovered in one instance only from the liver, but could not be recovered from the spleen or heart blood. The involvement of the kidneys, adrenal glands, coeliac ganglion and skin in the spread of infection was also studied. The possible role of the autonomic nervous system in the pathogenesis is suggested. In this respect, immunosympathectomy prior to inoculation reduced the incidence of infection in the adrenal glands and kidneys. Interruption of the sciatic and femoral nerves led to reduced mortality and an altered pathogenesis. A new pattern of virus isolation from the tissues was observed in mice dying at later times following section or ligation of these nerves. The electron microscope observations indicated that neurons rather than glia are of major importance in facilitating virus spread within and from the nervous system.
Psychiatric diagnoses as semiotic mediators: The case of ADHD

In cultural psychology, semiotic mediation refers to persons' use of signs to regulate thoughts, acts, and emotions. Drawing on an ongoing fieldwork in a support group for adults diagnosed with Attention Deficit/Hyperactivity disorder (ADHD), this paper highlights three specific functions that psychiatric diagnoses can have as semiotic mediators in the lives of the diagnosed: (1) an explanatory function in relation to experienced problems (even if a diagnosis is a description of symptoms, it is often used to explain these very symptoms), (2) a self-affirming function (in the sense that a diagnosis provides a framework according to which numerous phenomena appear as “symptoms”), and (3) a disclaiming function in relation to responsibility (with the possibility of medicalizing aspects of moral life). The legitimacy of each can be discussed, which in itself might add to the distress experienced by adults categorized by a contested diagnosis such as ADHD.
Physical Education in the National Curriculum: Its Purpose and Meaning for Final Year Secondary School Students

Despite the dearly presented objectives and general requirements of physical education within the National Curriculum in England and Wales, doubts have emerged as to whether these are fully appreciated and understood by those for whom it is designed. The purpose of this study was to investigate this issue through exploring pupils’ perceptions of their physical education programme, specifically in terms of what meaning, if any, they derived from the subject. The respondents within the study comprised 10 secondary school pupils who were divided into three focus groups. The resulting data yielded findings related to a general dislike of health related exercise, the continuing perception of physical education as recreation, the perception of the subject as being synonymous with sport and a general lack of understanding as to its educational purpose and value as stated in the National Curriculum.
A simulation study with quantity flexibility in a supply chain subjected to uncertainties

Coordination in supply chains is of vital importance to reduce the impact of system dynamics, which are usually caused by, but not limited to, uncertainty in terms of demand, supply, process, etc. Under such a distributed environment, supply chain problems can be formally modelled as a distributed constraint satisfaction problem (DCSP). The objectives of this paper are threefold: (i) to model a supply chain from the DCSP perspective; (ii) to develop a coordination mechanism in such a distributed supply chain with quantity flexibility for inventory management; and (iii) to examine the usefulness of the proposed methodology through a series of simulation studies. Results are compared with a stochastic model with the system subject to the same independent variables: demand and supply uncertainties. Simulation results indicate that the proposed mechanism can successfully filter the impact of the said uncertainties on the system performance including system cost, retailer cost, supplier cost, inventory cost and fill rate.
Lesion Size and Safety Comparison Between the Novel Flex Tip on the FlexAbility Ablation Catheter and the Solid Tips on the ThermoCool and ThermoCool SF Ablation Catheters

Next‐generation catheters have been developed to reduce irrigation volume and preserve power delivery. A novel design uses a flexible tip (FlexAbility™ catheter) that directs flow to the contact surface. Because of recent safety issues with new catheters, we undertook a study in a canine heart with 3 irrigated catheters to compare efficacy and safety.
Different revenue incentives, different content? Comparing economic news before and during the financial crisis in German public and commercial news outlets over time

This study argues that revenue model incentives determine news content. The goal to make profits and the need to sell audiences to advertisers guide journalists’ selection and interpretation of newsworthy material and result in commercialised news. We compare the volume, tone, and the obtrusiveness of topics in all economic news stories for the evening TV news of the public broadcasters ARD and ZDF, the commercial broadcaster RTL, and the tabloid newspaper BILD from 2002 to 2010 in Germany (n = 26,467). Results indicate that news selection is guided by revenue model incentives since economic news differs by volume and topic between public and commercial outlets. News interpretation, i.e., news tone, stronger varies across the media types TV and print. We conclude that advertising income dependency and observation of competitor behaviour transmits to operative journalistic practices and decisions, which in turn determine journalistic outcome.
Relationship between Pre-Pregnancy Body Mass Index, Physical Activity and Sedentary Lifestyles Before and During Pregnancy: A Cross-Sectional Study

Introduction: Pregnant women are recommended to participate in ‘moderate to vigorous’ physical activity (MVPA), each day, to promote and maintain health. The aim of this study was to assess the changes in Total Energy Expenditure (TEE), MVPA, physical activity levels in four different domains (leisure time, transportation, household/ caregiver, occupational), time spent watching TV, and numbers of women meeting the recommendations, before compared with during pregnancy, by body mass index category. Method: A systematic sample of otherwise healthy pregnant women attending their scheduled 20-22nd week assessment at a hospital in Spain during a 4 year period, 2004-2007, were asked for information on socio-demographic and medical information. They completed the Paffenbarger questionnaire and provided an estimate of their height and weight, both during the first half of their pregnancy and during the 12 months prior to their pregnancy. Results: 1.175 women agreed to take part. TEE decreased from pre-pregnancy in all BMI categories (21.77 to 18.89 in ideal; 24.20 to 21.56 in overweight; and 23.82 to 21.21 in obese women) (p<0.001). Physical activity levels in the transportation and leisure time domains, both before and during pregnancy were negligible across all BMI categories (mean around 1-1.5 MET hours/day), although LTPA did decline during pregnancy. Physical activity levels in the household/caregiver domain did not change as a result of pregnancy in any of the BMI categories (mean approx. 11 MET hours/day in ideal compared with approx 15 in overweight and obese categories). Physical activity levels declined in the occupational domain across all BMI categories. Discussion: Patterns of physical activity appear to be maintained during pregnancy, with the exception of occupational activity which decreases equally across all BMI categories. Motivating women, regardless their pregestational BMI index, to be physical active and less sedentary from the beginning and during pregnancy could potentially increase physical activity levels.
West Nile virus in blood: stability, distribution, and susceptibility to PEN110 inactivation

BACKGROUND: The outbreak of West Nile virus (WNV) is the most recent reminder that the blood supply continues to be vulnerable to emerging and reemerging pathogens. A potentially prospective approach to reducing the risk of transfusion‐transmitted infections of a known or newly emerging microbe is implementation of a broad‐spectrum pathogen reduction technology. The purpose of this study was to evaluate the susceptibility of WNV to PEN110 inactivation in RBCs and to characterize the WNV interaction with blood, including the stability of WNV in RBCs stored at 1 to 6°C, its distribution and infectivity, and its ability to infect WBCs.
Sunscreen habits and skin cancer rates in patients with vitiligo in Australia

contact wet wraps, was comparable to other studies where wet wraps are left in situ continually throughout the day. The advantages of the short-contact protocol include enhanced patients’ comfort, as they could move around between the treatments, and the regular application of emollient. The brevity and simplicity of this protocol would lend itself well to use in a daycare facility, although this was not assessed in our study. Although one-quarter of patients were readmitted, the median time to re-presentation of 3.4 months suggests that there was a prolonged treatment response to wet-wrap therapy. This re-admission rate may reflect the chronic and severe nature of the skin disease of many of these patients. Rapid reductions in the SCORAD index and psoriasis area and severity index were recorded, which were comparable to or surpassed many systemic and biological treatment options. Given that both eczema and psoriasis have a significant impact on productivity, the cost of inpatient admission should be weighed against the rapid return of patients in this relatively young cohort to their normal daily function and work. In addition, some of our inpatients received wet wraps to complement biological therapy, particularly during the initiation of treatment. The limitations of this study include the observational design. Wet wraps were administered in combination with a package of inpatient care processes in the absence of a vehicle-only control group for comparison. Disease scores were calculated by unblinded investigators, introducing potential measurement bias. The number of patients who returned the DLQI questionnaire after discharge was low and this should be noted when interpreting these results. Finally, follow-up data were collected from an analysis of clinical records rather than face-to-face reviews, meaning that the outcome measures may be underestimated. In conclusion, short-contact wet wraps delivered in an inpatient setting resulted in rapid clinical improvement for adults with severe dermatoses and may be considered as an alternative to more traditional continuous-contact wetwrap protocols.
Modelling HIV immune response and validation with clinical data

A system of ordinary differential equations is formulated to describe the pathogenesis of HIV infection, wherein certain features that have been shown to be important by recent experimental research are incorporated in the model. These include the role of CD4+memory cells that serve as a major reservoir of latently infected cells, a critical role for T-helper cells in the generation of CD8 memory cells capable of efficient recall response, and stimulation by antigens other than HIV. A stability analysis illustrates the capability of this model in admitting multiple locally asymptotically stable (locally a.s.) off-treatment equilibria. We show that this more biologically detailed model can exhibit the phenomenon of transient viremia experienced by some patients on therapy with viral load levels suppressed below the detection limit. We also show that the loss of CD4+T-cell help in the generation of CD8+memory cells leads to larger peak values for the viral load during transient viremia. Censored clinical data is used to obtain parameter estimates. We demonstrate that using a reduced set of 16 free parameters, obtained by fixing some parameters at their population averages, the model provides reasonable fits to the patient data and, moreover, that it exhibits good predictive capability. We further show that parameter values obtained for most clinical patients do not admit multiple locally a.s off-treatment equilibria. This suggests that treatment to move from a high viral load equilibrium state to an equilibrium state with a lower (or zero) viral load is not possible for these patients.
Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women

Metabolic syndrome (MS) is widespread in the human population, and its incidence is continuously increasing, generating serious health problems. The purpose of this study was to find the relationship between the parameters of MS and the melanocortin type 4 receptor (MC4R) gene polymorphism in postmenopausal women. The study involved 344 healthy Polish women, who had their last menstrual cycle 1 year ago or earlier. The study included blood analysis, survey, and body measurements. The mean age was 58.5±6.6 years. An increased body mass index was observed in 65.7% and abdominal obesity in 80.3% of the study population. MS was diagnosed in 40.7% of all participants, including 39.3% of women with the T/T genotype and 44.7% of those with the C/X genotype (χ2 test; P>0.05). A logistic regression model showed that the probability of MS was higher in patients with the C/X genotype (odds ratio =1.25) (χ2 test; P>0.05). The study concluded that MS is a very common condition among postmenopausal women. The C/X genotype of the MC4R gene seems to predispose postmenopausal women to developing some MS symptoms.
Beyond ‘what works’: understanding teacher identity as a practical and political tool

Drawing on previous research that focused upon the formation and mediation of teacher professional identity, this paper develops a model for conceptualising teacher professional identity. Increasingly, technical-rational understandings of teachers’ work and ‘role’ are privileged in policy and public discourse over more nuanced and holistic approaches that seek to understand teacher professional identity – what it is to ‘be’ a teacher. This article seeks to offer an alternative view, presenting the idea that an understanding of the processes by which teacher professional identity is formed and mediated is central to understanding the professional learning and development needs of teachers and advancing a richer, more transformative vision for education. I argue that instrumentalist notions of teachers’ work embedded in neo-liberal educational agendas such as those currently being advanced in many western countries offer an impoverished view of the teaching profession and education more broadly, and suggest that the concept of teacher professional identity holds the potential to work as a practical tool for the teaching profession and those who work to support them in the development of a more generative educational agenda.
Traditional Chinese Medicine Use and Health in Community‐Dwelling Chinese‐American Older Adults in Chicago

Chinese people have practiced traditional Chinese medicine (TCM) for thousands of years, but there is a paucity of research regarding TCM use in Chinese older adult immigrants in the United States. This study aims to provide an overall estimate of TCM use for Chinese older adults in the United States and to examine associations between sociodemographic characteristics, health measures, and TCM use. Data were collected through the Population Study of Chinese Elderly in Chicago, a community‐based participant research study that surveyed 3,158 Chinese older adults aged 60 and older. TCM use was measured using an eight‐item scale that examined eight kinds of TCM. Seventy‐six percent of participants reported any use of TCM within the past year. After adjusting for potential confounding factors, health status was associated with greater use of acupuncture (odds ratio (OR) = 1.33, 95% confidence interval (CI) = 1.06–1.68) and massage therapy (OR = 1.53, 95% CI = 1.21–1.93), and quality of life was associated with less use of prescribed herbal products (OR 0.69, 95% CI = 0.55–0.87), tai chi (OR = 0.62, 95% CI = 0.50–0.78), and other traditional medicine (OR = 0.47, 95% CI = 0.40–0.56). These findings call for further investigation of TCM use by Chinese older adults, especially those with poor health and those with better quality of life. In the clinical setting, physicians should have awareness of TCM when treating Chinese older adults and look toward possible integration with Western medicine for more culturally appropriate, patient‐centered care.
Staff Support, Staff Stress and Job Satisfaction in Working with People with Learning Disabilities and Challenging Behaviours

In the context of a staff development programme, the relationships between work‐related stress, staff support and job satisfaction were explored among staff groups in two residential assessment and treatment facilities for people with learning disabilities and challenging behaviour. Although overall support was relatively high for both formal and informal supports, only the informal supports from colleagues were negatively correlated with ratings of work‐related stress. Work‐related stress and job satisfaction were shown to be independent factors, and thus levels of stress could not be inferred from overall ratings of job satisfaction, or vice versa. The study identified a potentially vulnerable group of staff who reported relatively high job satisfaction but also some degree of stress.
The nature of learning being facilitated by frontline managers

This article, which is based on research conducted at five Australian organizations, explores the role frontline managers play in promoting and facilitating learning at work, an area in the field of workplace learning and human resource development that has not been extensively researched. This article provides a brief review of the literature, outlines the theoretical framework and research methodology and design utilized and presents the research findings and a brief discussion. The results of this study suggest that frontline managers, who were considered leaders of learning within their respective organizations, take an instrumental approach to leading employee learning, that is, learning is seen largely as a mechanism for getting work done. Additional evidence suggests that some frontline managers provide a more expansive learning environment through the purposeful creation of conditions for learning for their employees, beyond the immediate focus on learning, simply for the purpose of getting the work done. A further finding is that much of what frontline managers do in the promotion and facilitation of employee learning is deeply embedded in the idea and practice of being an effective manager. It is hoped that the findings will provide guidance to human resource development and frontline managers in shaping learning at work.