Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and Assessment of a Distal Radial Fracture Model as a Clinical Teaching Tool.

BACKGROUND Simulation-based learning is increasingly prevalent in the curricula of many surgical training programs. Newly developed simulators must undergo rigorous validity testing before they are used to assess and evaluate surgical trainees. We describe the development of a model that simulates a distal radial fracture requiring closed reduction and cast application and demonstrate its validity. METHODS We developed a model for simulated treatment of a distal radial fracture with use of a modified Sawbones forearm. Ten junior and ten senior orthopaedic residents were videotaped performing a closed reduction and applying a cast on the model. After each procedure, standard anteroposterior and lateral radiographs of the forearm model were obtained. Two blinded orthopaedic surgeons then rated each resident using a task-specific checklist (Objective Structured Assessment of Technical Skills [OSATS]) and a global rating scale (GRS) as well as radiographic measurements of palmar tilt and three-point index. RESULTS Compared with the junior residents, senior residents had significantly higher OSATS (p < 0.001) and GRS scores (p < 0.001). The groups did not differ significantly with respect to radiographic palmar tilt (p = 0.86) and three-point index (p = 0.43). All residents were able to restore anatomical alignment, with a mean palmar tilt of 9.1°. In addition, the mean three-point index of all residents was acceptable (0.76). There was a strong correlation between OSATS and GRS scores (r > 0.87; p < 0.01). The inter-rater reliability was high (≥ 0.79) for the OSATS, GRS, and radiographic measurements. CONCLUSIONS We developed an educational model that simulates a distal radial fracture requiring closed reduction and cast application. We demonstrated construct validity, as the GRS and OSATS tools were able to differentiate senior from junior residents. We were unable to differentiate trainees using radiographic assessment, as all residents restored anatomical alignment and had comparable three-point index scores.
The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase

T-cell activation requires two signaling events. One is provided by the engagement of the T-cell antigen receptor, and the second represents a costimulatory signal provided by antigen-presenting cells. CD28 mediates a costimulatory signal by binding its ligands, B7-1 and B7-2, on antigen-presenting cells, but the signaling pathway activated by CD28 has not been identified. A homologous molecule, CTLA-4, expressed on activated T cells, also binds to B7-1 and B7-2, but whether it has a signaling function is not known. We performed a structure-function analysis of CD28 to identify the functional domain which activates signal transduction. Truncation of the 40-amino-acid CD28 cytoplasmic tail abrogated costimulatory signaling. Chimeric constructs containing the extracellular and transmembrane regions of CD8 linked to the cytoplasmic region of CD28 had a costimulatory signaling function. Similar chimeras containing the cytoplasmic tail of CTLA-4 did not signal. Thus, the cytoplasmic region of CD28, but not CTLA-4, is sufficient to mediate costimulatory signaling. In addition, after CD28 stimulation, the p85 subunit of phosphatidylinositol 3'-kinase and phosphatidylinositol 3'-kinase activity were found in CD28 immunoprecipitates. The CD8-CD28 chimera, which has a costimulatory signaling function, associates with p85, while the nonfunctioning CD8-CTLA-4 chimera and a CD8-zeta chimera do not associate with p85. These results suggest that phosphatidylinositol 3'-kinase is specifically activated by CD28 and may mediate proximal events in the costimulatory signaling pathway regulated by CD28.
Causality : Objectives and Assessment

The NIPS 2008 workshop on causality provided a forum for researchers from different horizons to share their view on causal modeling and address the difficult question of assessing causal models. There has been a vivid debate on properly separating the notion of causality from particular models such as graphical models, which have been dominating the field in the past few years. Part of the workshop was dedicated to discussing the results of a challenge, which offered a wide variety of applications of causal modeling. We have regrouped in these proceedings the best papers presented. Most lectures were videotaped or recorded. All information regarding the challenge and the lectures are found at http://www.clopinet. com/isabelle/Projects/NIPS2008/. This introduction provides a synthesis of the findings and a gentle introduction to causality topics, which are the object of active
Syntactic/Semantic Structures for Textual Entailment Recognition

In this paper, we describe an approach based on off-the-shelf parsers and semantic resources for the Recognizing Textual Entailment (RTE) challenge that can be generally applied to any domain. Syntax is exploited by means of tree kernels whereas lexical semantics is derived from heterogeneous resources, e.g. WordNet or distributional semantics through Wikipedia. The joint syntactic/semantic model is realized by means of tree kernels, which can exploit lexical related-ness to match syntactically similar structures, i.e. whose lexical compounds are related. The comparative experiments across different RTE challenges and traditional systems show that our approach consistently and meaningfully achieves high accuracy, without requiring any adaptation or tuning.
Array diagnosis from far field data via ℓ1 minimizations

In this contribution the use of ℓ1 minimization for the diagnosis of arrays from far-field data is investigated. Numerical results show that reweighted method gives a higher probability of an accurate estimation of the failures compared to the classic ℓ1 minimization proposed in the past literature, confirming the results obtained by the authors in the framework of near-field measurements.
Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism

Zinc supplementation is recommended in all acute diarrheas in children from developing countries. We aimed to assess whether zinc supplementation would be equally effective against all the common organisms associated with acute diarrheas. We used data on 801 children with acute diarrhea recruited in a randomized, double blind controlled trial (ISRCTN85071383) of zinc and copper supplementation. Using prespecified subgroup analyses, multidimensionality reduction analyses, tests of heterogeneity, and stepwise logistic regression for tests of interactions, we found that the influence of zinc on the risk of diarrhea for more than 3 days depended on the isolated organism—beneficial in Klebsiella, neutral in Esherichia coli and parasitic infections, and detrimental in rotavirus coinfections. Although we found similar results for the outcome of high stool volume, the results did not reach statistical significance. Our findings suggest that the current strategy of zinc supplementation in all cases of acute diarrheas in children may need appropriate fine tuning to optimize the therapeutic benefit based on the causative organism, but further studies need to confirm and extend our findings.
CYP3A4*1G Genetic Polymorphism Influences Metabolism of Fentanyl in Human Liver Microsomes in Chinese Patients

Purpose: This study aimed to investigate whether CYP3A4*1G genetic polymorphism influences the metabolism of fentanyl in human liver microsomes in Chinese patients. Methods: The human liver microsomes were obtained from 88 hepatobiliary surgery patients who accepted liver resection surgery in this study. A normal liver sample (confirmed by the Department of Pathology) was taken from the outer edge of the resected tissue. The metabolism of fentanyl in human liver microsomes was studied. The concentration of fentanyl was measured by high performance liquid chromatography. The CYP3A4*1G variant allele was genotyped using the PCR restriction fragment length polymorphism method. Results: The frequency of the CYP3A4*1G variant allele was 0.188 in the 88 Chinese patients who had received hepatobiliary surgery. The metabolic rate of fentanyl in patients homozygous for the *1G/*1G variant (0.85 ± 0.37) was significantly lower than that in patients bearing the wild-type allele *1/*1 (1.89 ± 0.58) or in patients heterozygous for the *1/*1G variant (1.82 ± 0.65; p < 0.05). There were no gender-related differences in the metabolic rate of fentanyl (p > 0.05) nor was there any correlation between age and metabolic rate of fentanyl (p > 0.05). Results from different hepatobiliary diseases showed no significant difference in the metabolic rate of fentanyl (p > 0.05). The difference of CYP3A4 mRNA among different CYP3A4*1G variant alleles was significant (p < 0.05). There was positive correlation between CYP3A4 mRNA and metabolic rate of fentanyl (p < 0.01). Conclusions:CYP3A4*1G genetic polymorphism decreases the metabolism of fentanyl. There is a positive correlation between CYP3A4 mRNA level and metabolism of fentanyl.
The Reference Genome of the Halophytic Plant Eutrema salsugineum

Halophytes are plants that can naturally tolerate high concentrations of salt in the soil, and their tolerance to salt stress may occur through various evolutionary and molecular mechanisms. Eutrema salsugineum is a halophytic species in the Brassicaceae that can naturally tolerate multiple types of abiotic stresses that typically limit crop productivity, including extreme salinity and cold. It has been widely used as a laboratorial model for stress biology research in plants. Here, we present the reference genome sequence (241 Mb) of E. salsugineum at 8× coverage sequenced using the traditional Sanger sequencing-based approach with comparison to its close relative Arabidopsis thaliana. The E. salsugineum genome contains 26,531 protein-coding genes and 51.4% of its genome is composed of repetitive sequences that mostly reside in pericentromeric regions. Comparative analyses of the genome structures, protein-coding genes, microRNAs, stress-related pathways, and estimated translation efficiency of proteins between E. salsugineum and A. thaliana suggest that halophyte adaptation to environmental stresses may occur via a global network adjustment of multiple regulatory mechanisms. The E. salsugineum genome provides a resource to identify naturally occurring genetic alterations contributing to the adaptation of halophytic plants to salinity and that might be bioengineered in related crop species.
Subsistence hunting patterns and compliance with moose harvest reporting requirements in rural interior Alaska

The accounting of hunter harvests through the use of harvest tickets and other harvest reporting mechanisms is a basic tool of wildlife management. In interior and northern Alaska, harvest tickets and harvest reports have proven effective in recording the harvests of urban-based, non-Native hunters, but have had less success among predominantly Native hunters. Through key-respondent interviews with moose hunters in the interior Alaska communities of Fort Yukon, McGrath, and Nulato, this research examined some of the reasons behind non-compliance with moose harvest reporting requirements by hunters in these rural areas. In the three study communities, the percentage of hunters obtaining required licenses and harvest tickets varied according to the availability of these items locally, the presence of resident biologists or regulating agency staff to encourage compliance, and the perceived likelihood of an encounter between hunters and enforcement personnel. Harvest tickets were widely viewed as an m-season enforcement tool rather than a post-season reporting mechanism for harvest data. While the total harvest of moose by a particular community may have been well within sustainable limits, individual bag limits imposed by the present harvest ticket system, may be exceeded by some hunters, making them unlikely to participate in accurate harvest reporting. Respondents noted that the bag limit of one moose per hunter failed to accommodate the needs of many rural hunters due to customary patterns of group hunting and shared proceeds, the practice of one hunter providing food for multiple households, and individual households whose needs commonly exceeded one moose. These were the primary reasons given for the relative failure of the harvest ticket system in two of the study communities. These findings suggest that where accurate harvest data are needed for the sound management of resources harvested by rural subsistence hunters, alternatives to the present harvest ticket system should be considered and implemented. Transferable harvest tickets, post-season interviews with hunters, local residents or governing bodies who serve as village harvest recorders, and two Canadian harvest reporting programs are examined as potential alternatives.
L1 Cell Adhesion Molecule Is a Novel Independent Poor Prognostic Factor of Extrahepatic Cholangiocarcinoma

Purpose: Cholangiocarcinomas (CC) are associated with poor survival, but diagnostic markers and therapeutic targets have not yet been elucidated. We previously found aberrant expression of L1 cell adhesion molecule in intrahepatic CC and a role for L1 in the progression of intrahepatic CC. Here, we analyzed L1 expression in extrahepatic CC (ECC) and evaluated its prognostic significance. Experimental Design: We examined L1 expression in tumors from 75 ECC patients by immunohistochemistry. We analyzed the correlations between L1 expression and clinicopathologic factors as well as patient survival. Results: L1 was not expressed in normal extrahepatic bile duct epithelium but was aberrantly expressed in 42.7% of ECC tumors. High expression of L1 was detected at the invasive front of tumors and was significantly associated with perineural invasion (P < 0.01). Univariate analysis indicated that various prognostic factors such as histologic grade 3, advanced pathologic T stage and clinical stage, perineural invasion, nodal metastasis, and high expression of L1 were risk factors predicting patient survival. Multivariate analyses done by Cox's proportional hazards model showed that high expression of L1 (hazard ratio, 2.171; 95% confidence interval, 1.162-4.055; P = 0.015) and nodal metastasis (hazard ratio, 2.088; 95% confidence interval, 1.159-3.764; P = 0.014) were independent risk factors for patient death. Conclusions: L1 was highly expressed in 42.7% of ECC and its expression was significantly associated with perineural invasion. High expression of L1 and nodal metastasis were independent poor prognostic factors predicting overall survival in patients with ECC. (Clin Cancer Res 2009;15(23):7345–51)
Carnitine supplementation: effect on muscle carnitine and glycogen content during exercise.

This study investigated the effects of L-carnitine supplementation on muscle carnitine and glycogen content during submaximal exercise (EX). Triglycerides were evaluated by a fat feeding (90 g fat) and 3 h later subjects cycled for 60 min at 70% VO2max (CON). Muscle biopsies were obtained preexercise and after 30 and 60 min of EX. Blood samples were taken prior to and every 15 min of exercise. Subjects randomly completed two additional trials following 7 and 14 d of carnitine supplementation (6 g.d-1). During one of the two trials, subjects received 2000 units of heparin 15 min prior to EX to elevate FFA (CNhep); no heparin was administered during the other trial (CN). There were no differences in VO2, respiratory exchange ratio, heart rate, or g.min-1 of CHO and fat oxidized among the three trials. At rest serum total acid soluble (TASC) and free (FC) carnitine increased with supplementation (TASC; CON, 71.3 +/- 2.9; CN, 92.8 +/- 5.4; CNhep, 109.8 +/- 3.5 mumol.l-1) (FC; CON, 44.1 +/- 2.7; CN, 66.1 +/- 5.3; CNhep, 77.1 +/- 4.1 mumol.l-1). During EX, TASC remained stable, while FC decreased and short-chain acylcarnitine (SCAC) increased (P < 0.05). Muscle carnitine concentration at rest was unaffected by supplementation. During EX, muscle TASC did not change, FC decreased, and SCAC increased significantly in all three trials. Pre-EX and post-EX muscle glycogens were not different. Increased availability of serum carnitine does not result in an increase in muscle carnitine content nor does it alter lipid oxidation. It appears that there is an adequate amount of carnitine present within the mitochondria to support lipid oxidation.
Efficient Computation of EXIT Functions for Nonbinary Iterative Decoding

The calculation of nonbinary extrinsic information transfer charts for the iterative decoding of concatenated index-based codes is addressed. We show that the extrinsic information at the output of a constituent a posteriori probability decoder can be calculated with very low complexity, where expensive histogram measurements are not required any more. An example for turbo trellis-coded modulation demonstrates the capabilities of the proposed approach
Skeletal Deformities in the Elderly and Their Effect on Postural Sway

In a group of 151 elderly men and women (age range, 65–85+), postural sway was studied in relation to various physical attributes and skeletal deformities that might be contributory factors. Weight, loss of height (span‐height), scoliosis, grip strength, and the knee angle, measured laterally with the subject erect, all proved to be correlated with postural sway. Kyphosis was related to loss of muscle power and other general indications of frailty. Scoliosis appeared to be related to joint disease in the pelvis and lower limbs.
Defining interaction protocols using a commitment-based agent communication language

We propose a method for the definition of interaction protocols to be used in open multiagent systems. Starting from the assumption that language is the fundamental component of every interaction, we first propose a semantics for Agent Communication Languages based on the notion of social commitment, and then use it to define the meaning of a set of basic communicative acts. Second, we propose a verifiable and application-independent method for the definition of interaction protocols, whose main component is the specification of an interaction diagram specifying which actions may be performed by agents under given conditions. Interaction protocols fully rely on the application-independent meaning of communicative acts. We also propose a set of soundness conditions that can be used to verify whether a protocol is reasonable. Finally, our approach is exemplified by the definition of an interaction protocol for English auctions.
Multidrug Efflux Pumps from Enterobacteriaceae, Vibrio cholerae and Staphylococcus aureus Bacterial Food Pathogens

Foodborne illnesses caused by bacterial microorganisms are common worldwide and constitute a serious public health concern. In particular, microorganisms belonging to the Enterobacteriaceae and Vibrionaceae families of Gram-negative bacteria, and to the Staphylococcus genus of Gram-positive bacteria are important causative agents of food poisoning and infection in the gastrointestinal tract of humans. Recently, variants of these bacteria have developed resistance to medically important chemotherapeutic agents. Multidrug resistant Escherichia coli, Salmonella enterica, Vibrio cholerae, Enterobacter spp. , and Staphylococcus aureus are becoming increasingly recalcitrant to clinical treatment in human patients. Of the various bacterial resistance mechanisms against antimicrobial agents, multidrug efflux pumps comprise a major cause of multiple drug resistance. These multidrug efflux pump systems reside in the biological membrane of the bacteria and actively extrude antimicrobial agents from bacterial cells. This review article summarizes the evolution of these bacterial drug efflux pump systems from a molecular biological standpoint and provides a framework for future work aimed at reducing the conditions that foster dissemination of these multidrug resistant causative agents through human populations.
The Effects of Acupuncture at Real or Sham Acupoints on the Intrinsic Brain Activity in Mild Cognitive Impairment Patients

Accumulating neuroimaging studies in humans have shown that acupuncture can modulate a widely distributed brain network in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. Acupuncture at different acupoints could exert different modulatory effects on the brain network. However, whether acupuncture at real or sham acupoints can produce different effects on the brain network in MCI or AD patients remains unclear. Using resting-state fMRI, we reported that acupuncture at Taixi (KI3) induced amplitude of low-frequency fluctuation (ALFF) change of different brain regions in MCI patients from those shown in the healthy controls. In MCI patients, acupuncture at KI3 increased or decreased ALFF in the different regions from those activated by acupuncture in the healthy controls. Acupuncture at the sham acupoint in MCI patients activated the different brain regions from those in healthy controls. Therefore, we concluded that acupuncture displays more significant effect on neuronal activities of the above brain regions in MCI patients than that in healthy controls. Acupuncture at KI3 exhibits different effects on the neuronal activities of the brain regions from acupuncture at sham acupoint, although the difference is only shown at several regions due to the close distance between the above points.
Fraud Type and Auditor Litigation: An Analysis of SEC Accounting and Auditing Enforcement Releases

This study examines whether certain types of financial reporting fraud result in a higher likelihood of litigation against independent auditors. We expect that auditors are more likely to be judged responsible for failing to detect commonly occurring frauds or those that stem from fictitious transactions. We examine companies with SEC Accounting and Auditing Enforcement Releases and designate whether each fraud present in their financial statements is common and/or arises from fictitious transactions. We then examine whether these types of fraud are related to auditor litigation in analyses that control for various client, auditor and case characteristics. Our results provide some support for our two primary hypotheses-auditors are more likely to be sued when the financial statement frauds are of a common variety or when the frauds arise from fictitious transactions.
Decision Trees for Functional Variables

Classification problems with functionally structured input variables arise naturally in many applications. In a clinical domain, for example, input variables could include a time series of blood pressure measurements. In a financial setting, different time series of stock returns might serve as predictors. In an archaeological application, the 2D profile of an artifact may serve as a key input variable. In such domains, accuracy of the classifier is not the only reasonable goal to strive for; classifiers that provide easily interpretable results are also of value. In this work, we present an intuitive scheme for extending decision trees to handle functional input variables. Our results show that such decision trees are both accurate and readily interpretable.