Miracle-dz/UniFAR-FTUs huggingface dataset:
Drinking Motives Underlying Internalizing and Externalizing Pathways to Alcohol Misuse in College Students

DRINKING MOTIVES UNDERLYING INTERNALIZING AND EXTERNALIZING TRAJECTORIES OF ALCOHOL MISUSE By Jeanne E. Savage, B. A. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University Virginia Commonwealth University, 2017 Major Advisor: Danielle M. Dick, PhD Professor, Departments of Psychology and Human and Molecular Genetics Alcohol misuse, including heavy episodic use and negative consequences, is a major public health concern and a particular problem among college students. The etiology of alcohol misuse is not well resolved, with multiple and often contradictory factors implicated in its development. Genetic factors influence alcohol misuse but few specific genes have been identified. A potential reason for these challenges is that alcohol misuse is phenotypically and genetically heterogeneous; that is, there are multiple causal pathways underlying its development. Previous typologies have suggested that distinct internalizing and externalizing pathways are involved, with corresponding differences in profiles of personality, temperament, and comorbid psychopathology. Drinking motives, specifically drinking for positive reinforcement versus negative reinforcement motives, map intuitively onto such pathways and may provide a mechanism explaining their development. The aim of this project was to utilize drinking motives as intermediate phenotypic measures to investigate genetic and environmental factors contributing to the hypothesized diverging internalizing and externalizing pathways to alcohol misuse in a prospective, longitudinal sample of college students. Mixture modeling approaches identified distinct internalizing and externalizing subgroups with both quantitative and qualitative differences in traits/symptoms. The externalizing subgroup had a broader risk profile and elevated levels of both types of drinking motives, while the internalizing subgroup had specifically elevated levels of internalizing symptoms and negative reinforcement motives. Longitudinal analyses indicated stability of drinking motives throughout college and differential associations between positive/negative reinforcement motives and internalizing, externalizing, and alcohol misuse measures. Cross-lagged structural equation models pointed to a causal direction of effect of positive reinforcement motives on alcohol misuse. Finally, a series of genetic association analyses identified some promising genes and genetic variants underlying drinking motives and internalizing psychopathology, though their genetic etiologies remain largely inconclusive. The results of this project tie together several parallel lines of research on alcohol misuse and in the broader psychiatric genetics field. Findings support the existence of distinct, though not wholly separate, internalizing and externalizing subgroups, and suggest that the intermediate mechanisms of drinking motives are a valuable tool through which to understand these heterogeneous pathways to alcohol misuse.
A Grounded Theoretical Approach to Embodiment Among Homeless Youth

Using grounded theory methodology, this research explored, described and theorized about the ways youth, specifically homeless youth; make sense of their bodies within the context of living environments. It describes the relationship between body, space, and context for homeless youth in order to inform treatment options for this population. The importance of context, setting, and participant frame of reference was stressed, because embodiment is contextually and culturally influenced. The research addressed the questions: What is the process of becoming consciously embodied for homeless youth who have experienced multiple traumas? Do homeless youth who have experienced multiple traumas perceive a role for yoga therapy in the process of becoming consciously embodied? Interviews were conducted with 16 homeless youth, 2 agency administrators, and 1 yoga teacher who acknowledged that she was homeless in her youth. Interviews followed a general interview guide designed to elicit responses concerning trauma, homelessness, embodiment, and well-being. The research resulted in the development of a theoretical conceptualization of embodiment and trauma in homeless youth.
Stroll into students’ learning: Acts to unload teachers’ values through the practices of lesson study for learning community in Vietnam

In studies on teacher professional development, the embodiment of teachers’ values in professional practice has emerged as an important area of focus. Employing the sociocultural approach, this study discusses the link between teachers’ acts and underlying values based on a Vietnamese teacher’s detailed field notes on cases of school reform through the introduction of Japanese lesson study for learning community. Drawing on the concepts of inspection and stroll, the study describes the discrepancy between conventional observational acts and emerging ones. Inspection refers to the actions and values held by teachers that underline compliance with the prescribed curriculum and educational bureaucratic procedures, while stroll refers to a disposition that entails actions and values appreciating each pupil’s existence and learning as it is, without rigid bureaucratic perspectives. The finding was that the teacher’s act of stroll embeds new underlying values in her/his professional work; similarly, how she/he performs a stroll could inform her/his professional knowledge and identity. Lesson study can offer the teacher the experience of seeing self that generates the possible momentum of these parallel shifts.
Modelling cosmic ray intensities along the Ulysses trajectory

Abstract. Time dependent cosmic ray modulation in the inner heliosphere is studied by comparing results from a 2-D, time-dependent cosmic ray transport model with Ulysses observations. A compound approach, which combines the effects of the global changes in the heliospheric magnetic field magnitude with drifts to establish a realistic time-dependence, in the diffusion and drift coefficients, are used. We show that this model results in realistic cosmic ray modulation from the Ulysses launch (1990) until recently (2004) when compared to 2.5-GV electron and proton and 1.2-GV electron and Helium observations from this spacecraft. This approach is also applied to compute radial gradients present in 2.5-GV cosmic ray electron and protons in the inner heliosphere. The observed latitude dependence for both positive and negative charged particles during both the fast latitude scan periods, corresponding to different solar activity conditions, could also be realistically computed. For this an additional reduction in particle drifts (compared to diffusion) toward solar maximum is needed. This results in a realistic charge-sign dependent modulation at solar maximum and the model is also applied to predict charge-sign dependent modulation up to the next expected solar minimum.
Stable flocking of mobile agents, part I: fixed topology

This is the first of a two-part paper that investigates the stability properties of a system of multiple mobile agents with double integrator dynamics. In this first part we generate stable flocking motion for the group using a coordination control scheme which gives rise to smooth control laws for the agents. These control laws are a combination of attractive/repulsive and alignment forces, ensuring collision avoidance and cohesion of the group and an aggregate motion along a common heading direction. In this control scheme the topology of the control interconnections is fixed and time invariant. The control policy ensures that all agents eventually align with each other and have a common heading direction while at the same time avoid collisions and group into a tight formation.
Müller's muscle–conjunctival resection for upper eyelid ptosis: correlation between amount of resected tissue and outcome

Aims To explore the relationship between the amount of resected Müller's muscle–conjunctiva (MMCR) and clinical outcome in patients undergoing upper eyelid ptosis surgery. Methods 49 patients underwent 87 MMCR surgeries. The total areas of the specimen and of MM were measured in pixels. Results The average percentage of muscle tissue in relation to total excised tissue was 21%. Intraoperative MMC tissue measurements and postoperative improvement in eyelid position (delta marginal reflex distance 1 (MRD1)) were positively correlated (R=0.427, p=0.09). There was a weak correlation between total areas measured on the histological slides and the intraoperative MMCR values (R=0.3, p=0.057). Total histological areas did not correlate with the delta change in eyelid position or with the amount and percentage of resected muscle tissue and the extent of improvement in eyelid position (delta MRD1) or final eyelid position (postoperative MRD1). Conclusions Post-MMCR improvement in eyelid positions did not correlate with the percentage of MM in the excised tissue. We believe that the mechanism responsible for surgical outcome is plication or scarring of the posterior lamella and not the amount of resected MM. More lift in eyelid position can be anticipated when more tissue is excised by MMCR, and not when more muscle is excised.
Steroid and Neuronal Regulation of Ecdysone Receptor Expression during Metamorphosis of Muscle in the Moth, Manduca sexta

Ecdysteroids regulate the remodeling of the dorsal external oblique 1 (DEO1) muscle during metamorphosis in Manduca sexta(Hegstrom and Truman, 1996a). We show that the temporal and spatial patterning of the A and B1 isoforms of the ecdysone receptor (EcR) within muscle DEO1 corresponds with the developmental fates of the fibers. Using antibodies directed to specific isoforms of EcR, we show that the expression of various EcR isoforms in myonuclei differ among the five fibers of DEO1 and correspond with the developmental response of the muscle to the changing steroid titers and to the pattern of innervation. Muscle degeneration and apoptosis of myonuclei in all fibers are correlated with the expression of only EcR-A just before pupal ecdysis and then with the expression of low levels of both EcR-A and EcR-B1 shortly after pupation. Only the first fiber of muscle DEO1 participates in the regrowth of the adult muscle, and only this fiber shows an upregulation of EcR-B1 that is evident at 3 d after pupal ecdysis. Denervation of the muscle prevents both the upregulation of EcR-B1 and myoblast proliferation. We conclude that the developmental fate of muscle DEO1 during metamorphosis is orchestrated by interactions between rising and falling ecdysteroid titers, the pattern of expression of EcR isoforms by the muscle, and interactions with other cells in the local environment.
SAGE-Seq Gene expression profiling of human breast tissue samples using Material

object identifier (DOIs) and date of initial publication. by PubMed from initial publication. Citations to Advance online articles must include the digital publication). Advance online articles are citable and establish publication priority; they are indexed appeared in the paper journal (edited, typeset versions may be posted when available prior to final Advance online articles have been peer reviewed and accepted for publication but have not yet
Decreased IgA+ B Cells Population and IgA, IgG, IgM Contents of the Cecal Tonsil Induced by Dietary High Fluorine in Broilers

Fluoride is an environmental and industrial pollutant that affects various organs in humans and animals. The cecal tonsil is an important component of the mucosal immune system and performs important and unique immune functions. In the present study, we investigated the effects of dietary high fluorine on the quantities of IgA+ B cells in the cecal tonsil by immunohistochemistry, and the immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) contents in the cecal tonsil by ELISA. A total of 280 one-day-old avian broilers were divided into four groups and fed on a corn-soybean basal diet as control diet (fluorine 22.6 mg/kg) or the same diet supplemented with 400, 800 and 1,200 mg/kg fluorine (high fluorine groups I, II and III) in the form of sodium fluoride, respectively, throughout a 42-day experimental period. The results showed that the quantities of IgA+ B cells were lower (p < 0.05 or p < 0.01) and the IgA, IgG, and IgM contents were decreased (p < 0.05 or p < 0.01) in high fluorine groups II and III in comparison with those of control group. It was concluded that dietary fluorine, in the 800–1,200 mg/kg range, could reduce the numbers of the IgA+ B cells and immunoglobulin contents in the cecal tonsil, implying the local mucosal immune function was ultimately impacted in broilers.
Progressive Muscular Dystrophy in α-Sarcoglycan–deficient Mice

Limb-girdle muscular dystrophy type 2D (LGMD 2D) is an autosomal recessive disorder caused by mutations in the α-sarcoglycan gene. To determine how α-sarcoglycan deficiency leads to muscle fiber degeneration, we generated and analyzed α-sarcoglycan– deficient mice. Sgca-null mice developed progressive muscular dystrophy and, in contrast to other animal models for muscular dystrophy, showed ongoing muscle necrosis with age, a hallmark of the human disease. Sgca-null mice also revealed loss of sarcolemmal integrity, elevated serum levels of muscle enzymes, increased muscle masses, and changes in the generation of absolute force. Molecular analysis of Sgca-null mice demonstrated that the absence of α-sarcoglycan resulted in the complete loss of the sarcoglycan complex, sarcospan, and a disruption of α-dystroglycan association with membranes. In contrast, no change in the expression of ε-sarcoglycan (α-sarcoglycan homologue) was observed. Recombinant α-sarcoglycan adenovirus injection into Sgca-deficient muscles restored the sarcoglycan complex and sarcospan to the membrane. We propose that the sarcoglycan–sarcospan complex is requisite for stable association of α-dystroglycan with the sarcolemma. The Sgca-deficient mice will be a valuable model for elucidating the pathogenesis of sarcoglycan deficient limb-girdle muscular dystrophies and for the development of therapeutic strategies for this disease.
Characterization of Positive Cloud to Ground Flashes Observed in Indonesia

The characteristics of 77 electric field changes of positive cloud to ground (CG) flashes in the tropics of Indonesia were investigated. It was found that the arithmetic mean (AM) and geometric mean (GM) values for 0%–100% and 10%–90% rise time were 12.7 μs, 11.9 μs and 6.1 μs, 5.8 μs, respectively. The percentages of single, double, and triple strokes of lightning flashes were 83% (64 cases), 16% (12 cases), and 1% (1 case), respectively. The AM and GM of the interstroke intervals and the return stroke (RS) amplitude ratios were 163.9 ms, 0.29, and 13.3 ms, 0.26, respectively. Furthermore, it was also found that 7 (9%) of 77 positive CG flashes had double peak return stroke waveforms with AM and GM values for 0%–100% and 10%–90% rise time of subsequent return strokes that were 6.7 μs, 6.4 μs and 4.1 μs, 4 μs, respectively. We inferred that these double peaks are produced by two ground terminations with a time interval varying from 7 to 560 μs.
Numerical Study of an Anisotropic Error Estimator in the L2(H1) Norm for the Finite Element Discretization of the Wave Equation

An anisotropic a posteriori error estimate is derived for a finite element discretization of the wave equation in two space dimensions. Only the error due to space discretization is considered, and the error estimates are derived in the nonnatural $L^2(0,T;H^1(\Omega))$ norm using elliptic reconstruction. A numerical study of the effectivity index on unstructured, nonadapted, anisotropic meshes confirms the sharpness of the error estimator, provided the error due to time discretization is negligible compared to the finite element error. An anisotropic, adaptive finite element algorithm is then presented to control the finite element error in the $L^2(0,T;H^1(\Omega))$ norm. Numerical results on adapted meshes indicate that the error estimator slightly underestimates the true error. We conjecture that the missing information corresponds to the interpolation error between successive meshes. It is observed that the error estimator becomes sharp again when considering the damped wave equation \[\varepsilon\frac{\partial^{2}u}{\partial t^{2}}+\frac{\partial u}{\partial t}-\Delta u=f,\] with small values of $\varepsilon$, that is, when the parabolic character of the PDE becomes predominant.
Towers of MU-algebras and the generalized Hopkins-Miller theorem

Our results are of three types. First we describe a general procedure of adjoining polynomial variables to A ∞ -ring spectra whose coeﬃcient rings satisfy certain restrictions.A host of examples of such spectra is provided by killing a regular ideal in the coeﬃcient ring of MU , the complex cobordism spectrum. Second, we show that the algebraic procedure of adjoining roots of unity carries over in the topological context for such spectra. Third, we use the developed technology to compute the homotopy types of spaces of strictly multiplicative maps between suitable K ( n )-localizations of such spectra. This generalizes the famous Hopkins-Miller theorem and gives strengthened versions of various splitting theorems.
Combining Software Metrics and Text Features for Vulnerable File Prediction

In recent years, to help developers reduce time and effort required to build highly secure software, a number of prediction models which are built on different kinds of features have been proposed to identify vulnerable source code files. In this paper, we propose a novel approach VULPREDICTOR to predict vulnerable files, it analyzes software metrics and text mining together to build a composite prediction model. VULPREDICTOR first builds 6 underlying classifiers on a training set of vulnerable and non-vulnerable files represented by their software metrics and text features, and then constructs a meta classifier to process the outputs of the 6 underlying classifiers. We evaluate our solution on datasets from three web applications including Drupal, PHPMyAdmin and Moodle which contain a total of 3,466 files and 223 vulnerabilities. The experiment results show that VULPREDICTOR can achieve F1 and EffectivenessRatio@20% scores of up to 0.683 and 75%, respectively. On average across the 3 projects, VULPREDICTOR improves the F1 and EffectivenessRatio@20% scores of the best performing state-of-the-art approaches proposed by Walden et al. by 46.53% and 14.93%, respectively.
Physiological implications of arginine metabolism in plants

Nitrogen is a limiting resource for plant growth in most terrestrial habitats since large amounts of nitrogen are needed to synthesize nucleic acids and proteins. Among the 21 proteinogenic amino acids, arginine has the highest nitrogen to carbon ratio, which makes it especially suitable as a storage form of organic nitrogen. Synthesis in chloroplasts via ornithine is apparently the only operational pathway to provide arginine in plants, and the rate of arginine synthesis is tightly regulated by various feedback mechanisms in accordance with the overall nutritional status. While several steps of arginine biosynthesis still remain poorly characterized in plants, much wider attention has been paid to inter- and intracellular arginine transport as well as arginine-derived metabolites. A role of arginine as alternative source besides glutamate for proline biosynthesis is still discussed controversially and may be prevented by differential subcellular localization of enzymes. Apparently, arginine is a precursor for nitric oxide (NO), although the molecular mechanism of NO production from arginine remains unclear in higher plants. In contrast, conversion of arginine to polyamines is well documented, and in several plant species also ornithine can serve as a precursor for polyamines. Both NO and polyamines play crucial roles in regulating developmental processes as well as responses to biotic and abiotic stress. It is thus conceivable that arginine catabolism serves on the one hand to mobilize nitrogen storages, while on the other hand it may be used to fine-tune development and defense mechanisms against stress. This review summarizes the recent advances in our knowledge about arginine metabolism, with a special focus on the model plant Arabidopsis thaliana, and pinpoints still unresolved critical questions.
Pulsational Instabilities in Accreting White Dwarfs

The detection of g-mode pulsations in accreting white dwarfs (WDs) in cataclysmic variables (CVs) with a large range of effective temperatures (Teff) has shown these WDs to be a more diverse class than their isolated counterparts, the ZZ Ceti and DB pulsators. The simplest contrast of CV to isolated pulsators is an envelope of solar-like composition (of various helium enrichments if the donor is evolved) rather than pristine hydrogen or helium. A range of WD masses is expected, from low-mass He core WDs to massive WDs. We investigate the impact of this diversity on the range of Teff for which g-modes are unstable. Motivated by earlier theoretical studies, we compare a fiducial g-mode period to the thermal time at the base of the convection zones created by H and first He (H/He I) ionization or second He (He II) ionization zones. We find that (for solar composition envelopes), relative to a fiducial WD mass 0.6 M☉, the blue edge for a 0.4 M☉ He core WD shifts downward by ≈1000 K, while that for a massive ≈1.2 M☉ WD shifts upward by ≈2000 K. Surprisingly, increasing Y by only 10% relative to solar creates an "intermediate" instability strip near 15,000 K.
The resource‐based view of strategy and its value to practising managers

•A dominant theoretical paradigm in academic strategic management circles is the Resource-Based View (RBV). This paper reviews the literature of this position and the extent to which the RBV may be seen as a source of practical guidance for managers seeking competitive advantage and strategic success. •The theories of management academics should be of practical value to managers, otherwise such theories are of limited value. The test of the validity of theorizing about management is whether the theories produced help to improve the art of management. That is the criterion adopted in this paper. •The RBV is an ‘inside-out’ perspective, according to which, competitive success lies within the hands of managers themselves and it is from the point of view of practising managers that this paper examines competitiveness. Consequently, the assessment of the RBV will be a purely instrumental one. Does it help managers to manage better? Copyright © 2002 John Wiley & Sons, Ltd.