Miracle-dz/UniFAR-FTUs huggingface dataset:
Counselling Strategies for Modifying Bullying Behaviour in Nigerian Schools

Bullying is an aggressive behaviour that is very rampant at both primary and secondary levels of Nigerian educational system regardless of the size and type of the schools. It is a worrisome practice in schools and it deserves special attention. Bullying is a form of deviant behaviour that is usually ignored by many teachers, counsellors and school administrators due to its salient but adverse effect. Recently, there has been a growing concern for the increasing level of students’ unrest, violence, sexual victimization and cultism in Nigerian schools, all of which are extensions of bullying behaviour which makes it necessary to examine the counselling strategies for modifying it. This paper therefore identified the various strategies that can be used in reducing bullying in schools, while suggesting the comprehensive whole school approach. There is the need for school counsellors to acquire skills in using the various strategies as well as sensitising the principals, teachers, parents and students to the phenomenon of bullying so that they can take roles in bullying prevention as specified in the whole school approach. The paper also made suggestions on how counsellors can seek collaborations among various stakeholders and meet with them in planning and implementing the various strategies related to their roles. Keywords: Bullying, Bullies, Bully Victims, Counselling Strategies, Nigeria, Schools
The Tribological Properties of Zinc Borate Ultrafine Powder as a Lubricant Additive in Sunflower Oil

This article presents an investigation on the tribological properties of zinc borate ultrafine powder (ZBUP) employed as a lubricant additive in sunflower oil. The stable dispersions of 0.5, 1, and 2 wt% ZBUP in sunflower oil were achieved using an ultrasonic homogenizer. Both a four-ball tester and a pin-on-disc tester were employed to evaluate the antiwear and friction reduction capabilities of ZBUP. Tribofilms with a dark color were generated on the worn surfaces and showed good contrast with the substrate. The worn surface with different morphologies reflected as color alterations on the worn surface were observed when different lubricants were applied. The morphology and elemental analysis of the worn surfaces were studied using atomic force microscopy (AFM) and scanning electronic microscopy (SEM). Mechanical properties of the tribofilms and substrates were studied with a nano-indentation tester. Test results suggest that tribofilms generated on the worn surface have relatively low hardness compared with the steel substrate. The substrates on the worn surfaces lubricated in sunflower oil with the powder demonstrated higher hardness than the substrate lubricated with pure sunflower oil due to the possible tribochemical reaction between the zinc borate additive and substrate. The combination of sunflower oil with 0.5% ZBUP delivered the most balanced performance in friction and wear reduction. This study has demonstrated the possibility of application of this industrially applicable solid lubricant additive (zinc borate) with a decomposable vegetable-based lubricant oil.
Ribonucleotide Reductase Large Subunit (RRM1) Gene Expression May Predict Efficacy of Adjuvant Mitotane in Adrenocortical Cancer

Purpose: Mitotane is the most broadly used systemic therapy for adrenocortical carcinoma (ACC), but its mechanism of action and possible predictors of treatment response are currently poorly defined. Our aim was to evaluate the gene expression of ribonucleotide reductase large subunit 1 (RRM1) and excision repair cross-complementation group 1 (ERCC1) in ACC as potential biomarkers for clinical outcome and response to mitotane. Experimental Design: Forty-five and 47 tissue samples from two cohorts (Orbassano, Italy; Wuerzburg, Germany) of completely resected ACC were centrally analyzed using real-time PCR for RRM1 and ERCC1 expression. Fifty-four patients received surgery alone and 38 received adjuvant mitotane after surgery. Clinical and pathologic features were highly comparable in the two series. H295R and SW-13 ACC cell lines were also used for pharmacologic tests. Results: ERCC1 gene expression was not associated to clinical outcome. In contrast, high RRM1 gene expression was associated to shorter disease-free survival (DFS) and overall survival at both univariate and multivariate analysis. In patients with low RRM1 gene expression, adjuvant mitotane was associated with improved DFS, whereas this effect was lost in cases with high RMM1 expression. In vitro mitotane induced strong up regulation of RRM1 transcription (up to 25-fold increase) in mitotane-insensitive SW-13 but not in mitotane-sensitive H295R cells. Furthermore, RRM1 silencing in SW-13 cells induced sensitivity to mitotane. Conclusion: Our in vitro and in vivo data indicate that RRM1 gene expression is functionally associated to mitotane sensitivity and support a possible role of RRM1 determination as a novel molecular biomarker predicting response to adjuvant mitotane in ACC. Clin Cancer Res; 18(12); 3452–61. ©2012 AACR.
Incidence of low-grade infection in aseptic loosening of total hip arthroplasty

Purpose We investigated the hypothesis that many total hip arthroplasty revisions that are classified as aseptic are in fact low-grade infections missed with routine diagnostics. Methods In 7 Dutch hospitals, 176 consecutive patients with the preoperative diagnosis of aseptic loosening of their total hip arthroplasty were enrolled. During surgery, between 14 and 20 tissue samples were obtained for culture, pathology, and broad-range 16S rRNA PCR with reverse line blot hybridization. Patients were classified as either not being infected, suspected of having infection, or infected according to strict, predefined criteria. Each patient had a follow-up visit after 1 year. Results 7 patients were classified as infected, 4 of whom were not identified by routine culture. 15 additional patients were suspected of having infection. 20 of these 22 patients received a cemented prosthesis, fixated with antibiotic-loaded bone cement. All 22 patients received prophylactic systemic antibiotics. 7 of them reported complaints one year after surgery, but only one showed signs of early loosening. However, additional surgery was not performed in any of the patients. Interpretation Although the proportions were not as high as previously reported in the literature, between 4% and 13% of patients with the preoperative diagnosis of aseptic loosening were infected. However, as thorough debridement was performed during surgery and prophylactic antibiotics were used, the diagnosis of infection did not have any obvious clinical consequences, as most patients performed well at the 1-year follow-up. Whether this observation has implications for long-term implant survival remains to be seen.
Intrusion Detection System Using Bagging Ensemble Method of Machine Learning

Intrusion detection system is widely used to protect and reduce damage to information system. It protects virtual and physical computer networks against threats and vulnerabilities. Presently, machine learning techniques are widely extended to implement effective intrusion detection system. Neural network, statistical models, rule learning, and ensemble methods are some of the kinds of machine learning methods for intrusion detection. Among them, ensemble methods of machine learning are known for good performance in learning process. Investigation of appropriate ensemble method is essential for building effective intrusion detection system. In this paper, a novel intrusion detection technique based on ensemble method of machine learning is proposed. The Bagging method of ensemble with REPTree as base class is used to implement intrusion detection system. The relevant features from NSL_KDD dataset are selected to improve the classification accuracy and reduce the false positive rate. The performance of proposed ensemble method is evaluated in term of classification accuracy, model building time and False Positives. The experimental results show that the Bagging ensemble with REPTree base class exhibits highest classification accuracy. One advantage of using Bagging method is that it takes less time to build the model. The proposed ensemble method provides competitively low false positives compared with other machine learning techniques.
Heads, Hox and the phylogenetic position of trilobites

The Arachnomorpha or Arachnata concepts have resolved Trilobita as most closely related to Chelicerata amongst extant Arthropoda. An alternative position of trilobites in the stem lineage of Mandibulata is suggested by their pattern of head tagmosis. The antennae of trilobites and Mandibulata are considered non-homologous with the antennae of Onychophora and stem lineage Euarthropoda: they represent ‘secondary’ and ‘primary antennae’, respectively. In extant taxa, ‘secondary antennae’ are deutocerebral, post-ocular, and are connected to deutocerebral olfactory neuropils, whereas ‘primary antennae’ are pre-ocular and connected to protocerebral olfactory neuropils. In fossils, an insertion at the anterolateral margin of the hypostome rather than more anteriorly on the head allows ‘secondary antennae’ to be identified. A deutocerebral mouthpart, of which the onychophoran jaw and the chelicera are examples, is regarded as plesiomorphic for Arthropoda. A loss of ‘primary antennae’ and modification of the deutocerebral mouthpart into a sensory antenna defines the Mandibulata. Trilobites share a ‘secondary antenna’ and a clearly-delimited head tagma with mandibulates. Given the extensive homoplasy forced by the Arachnata concept (reversals in pycnogonids and arachnids), a trilobite/mandibulate alliance may be better supported. Dedicated to Fred Schram on the occasion of his retirement. Our article challenges canonical views about arthropods, and we were forced to question ideas that we have long considered the best explanation of facts. In doing so, we venture into a territory from which Fred Schram has never shied away. Fred’s synthesis of data from living and fossil arthropods, his efforts to integrate classical morphological and evo-devo perspectives, and his willingness to explore dangerous ideas have inspired our reappraisal of the trilobite problem.
Purinergic P2X7 Receptors Mediate Cell Death in Mouse Cerebellar Astrocytes in Culture

The brain distribution and functional role of glial P2X7 receptors are broader and more complex than initially anticipated. We characterized P2X7 receptors from cerebellar astrocytes at the molecular, immunocytochemical, biophysical, and cell physiologic levels. Mouse cerebellar astrocytes in culture express mRNA coding for P2X7 receptors, which is translated into P2X7 receptor protein as proven by Western blot analysis and immunocytochemistry. Fura-2 imaging showed cytosolic calcium responses to ATP and the synthetic analog 3′-O-(4-benzoyl)benzoyl-ATP (BzATP) exhibited two components, namely an initial transient and metabotropic component followed by a sustained one that depended on extracellular calcium. This latter component, which was absent in astrocytes from P2X7 receptor knockout mice (P2X7 KO), was modulated by extracellular Mg2+, and was sensitive to Brilliant Blue G (BBG) and 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl pyridine (A438079) antagonism. BzATP also elicited inwardly directed nondesensitizing whole-cell ionic currents that were reduced by extracellular Mg2+ and P2X7 antagonists (BBG and calmidazolium). In contrast to that previously reported in rat cerebellar astrocytes, sustained BzATP application induced a gradual increase in membrane permeability to large cations, such as N-methyl-d-glucamine and 4-[3-methyl-2(3H)-benzoxazolylidene)-methyl]-1-[3-(triethylammonio)propyl]diiodide, which ultimately led to the death of mouse astrocytes. Cerebellar astrocyte cell death was prevented by BBG but not by calmidazolium, removal of extracellular calcium, or treatment with the caspase-3 inhibitor, benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone, thus suggesting a necrotic-type mechanism of cell death. Since this cellular response was not observed in astrocytes from P2X7 KO mice, this study suggests that stimulation of P2X7 receptor may convey a cell death signal to cerebellar astrocytes in a species-specific manner.
Further Progress, Persistent Constraints: Findings From a Second Survey of the Welfare-to-Work Grants Program. Princeton, NJ: Mathematica Policy Research

Finds that most WtW grantees, except recently funded ones, are now delivering services, but restrictive eligibility rules still in effect in late 1999 continue to impede enrollment. Despite low enrollment, grantees have moved expeditiously to place WtW participants in work activities. To date, most placements have been in service and administrative support positions that participants can get even with limited skills and poor work history, but unsubsidized wages average just $6.81 per hour and opportunities for advancement are often limited.
The 69 Millisecond Radio Pulsar near the Supernova Remnant RCW 103

We report the detection of the radio pulsar counterpart to the 69 ms X-ray pulsar discovered near the supernova remnant RCW 103 (G332.4-0.4). Our detection confirms that the pulsations arise from a rotation-powered neutron star, which we name PSR J1617-5055. The observed barycentric period derivative confirms that the pulsar has a characteristic age of only 8 kyr, the sixth youngest of all known pulsars. The unusual apparent youth of the pulsar and its proximity to a young remnant require that an association be considered. Although the respective ages and distances are consistent within substantial uncertainties, the large inferred pulsar transverse velocity is difficult to explain given the observed pulsar velocity distribution, the absence of evidence for a pulsar wind nebula, and the symmetry of the remnant. Rather, we argue that the objects are likely superposed on the sky; this is reasonable given the complex area. Without an association, the question of where is the supernova remnant left behind following the birth of PSR J1617-5055 remains open. We also discuss a possible association between PSR J1617-5055 and the γ-ray source 2CG 333+01. Although an association is energetically plausible, it is unlikely given that EGRET did not detect 2CG 333+01.
Solving the maximum clique problem by k-opt local search

This paper presents a local search algorithm based on variable depth search, called the k-opt local search, for the maximum clique problem. The k-opt local search performs add and drop moves, each of which can be interpreted as 1-opt move, to search a k-opt neighborhood solution at each iteration until no better k-opt neighborhood solution can be found. To evaluate our k-opt local search algorithm, we repeatedly apply the local search for each of DIMACS benchmark graphs and compare with the state-of-the-art metaheuristics such as the genetic local search and the iterated local search reported previously. The computational results show that in spite of the absence of major metaheuristic components, the k-opt local search is capable of finding better (at least the same) solutions on average than those obtained by these metaheuristics for all the graphs.
Striatal presynaptic dopamine in schizophrenia, part II: meta-analysis of [(18)F/(11)C]-DOPA PET studies.

BACKGROUND Alterations in striatal dopamine neurotransmission are central to the emergence of psychotic symptoms and to the mechanism of action of antipsychotics. Although the functional integrity of the presynaptic system can be assessed by measuring striatal dopamine synthesis capacity (DSC), no quantitative meta-analysis is available. METHODS Eleven striatal (caudate and putamen) [(11)C/(18)F]-DOPA positron emission tomography studies comparing 113 patients with schizophrenia and 131 healthy controls were included in a quantitative meta-analysis of DSC. Demographic, clinical, and methodological variables were extracted from each study or obtained from the authors and tested as covariates. Hedges' g was used as a measure of effect size in Comprehensive Meta-Analysis. Publication bias was assessed with funnel plots and Egger's intercept. Heterogeneity was addressed with the Q statistic and I(2) index. RESULTS Patients and controls were well matched in sociodemographic variables (P > .05). Quantitative evaluation of publication bias was nonsignificant (P = .276). Heterogeneity across study was modest in magnitude and statistically nonsignificant (Q = 19.19; P = .078; I (2) = 39.17). Patients with schizophrenia showed increased striatal DSC as compared with controls (Hedges' g = 0.867, CI 95% from 0.594 to 1.140, Z = 6.222, P < .001). The DSC schizophrenia/control ratio showed a relatively homogenous elevation of around 14% in schizophrenic patients as compared with controls. DSC elevation was regionally confirmed in both caudate and putamen. Controlling for potential confounders such as age, illness duration, gender, psychotic symptoms, and exposure to antipsychotics had no impact on the results. Sensitivity analysis confirmed robustness of meta-analytic findings. CONCLUSIONS The present meta-analysis showed consistently increased striatal DSC in schizophrenia, with a 14% elevation in patients as compared with healthy controls.
Trend of Cardio-Metabolic Risk Factors in Polycystic Ovary Syndrome: A Population-Based Prospective Cohort Study

Objective To see the changes of cardio-metabolic risk factors overtime in polycystic ovary syndrome vs. control women. Methods This study was conducted on 637 participants (85 PCOS and 552 control reproductive aged, 18–45 years) of Tehran Lipid and Glucose Study (TLGS), an ongoing population-based cohort study with 12 years of follow-up. The cardiovascular risk factors of these groups were assessed in three-year intervals using standard questionnaires, history taking, anthropometric measures, and metabolic/endocrine evaluation. Generalized estimating equation was used to analyze the data. Results Overall mean of insulin (3.55, CI: 0.66–6.45), HOMA-IR (0.63, CI: 0.08–1.18), and HOMA-β (45.90, CI: 0.86–90.93) were significantly higher in PCOS than in healthy women after adjustment for age, BMI, and baseline levels. However, the negative interaction (follow-up years × PCOS status) of PCOS and normal women converged overtime. Comparing third follow-up with first, insulin and HOMA-IR decreased 10.6% and 5%, respectively in PCOS women; and increased 6.7% and 14.6%, respectively in controls (P<0.05). The results did not show any significant result for other cardio-metabolic variables including WC, lipid profile, FPG, 2-h PG, SBP, and DBP. Conclusion While the insulin level and insulin resistance rate were higher in reproductive aged PCOS than in healthy women, the difference of these risk factors decreased overtime. Thus, the metabolic consequences of PCOS women in later life may be lower than those initially anticipated.
The construction of the active, involved patient

The patient role has been discussed in western health systems literature for decades. In this discourse analysis, based on the work of the French philosopher Michel Foucault, we analyzed a broad selection of Danish materials in the field of healthcare. We found that patient involvement is a discursive ideal. The ideal is anchored in implicit assumptions about the characteristics and capacities that the patient is expected to acquire and display: the patient must be active, knowledgeable, a competent decision-maker, obtain insight into own disease, and have supportive relatives. To achieve the ideal of patient participation we suggest that there is a need for a certain type of active patient; otherwise patient involvement plans cannot succeed. We identified a single discursive strategy in which the patient was attributed the role of being actively involved by addressing the patient’s characteristics, skills, desires, actions and expectations. Finally, we discussed how this patient role could actually increase health inequality despite intentions to the contrary.
SQUARE: A New TCP Variant for Future High Speed and Long Delay Environments

The increasing diversity of Internet application requirements has spurred recent interest in transport protocol for high speed delay product connectivity. Addressing the deficiency of previous protocols, this paper presents a spectrum of time based odd function congestion control protocols for deployment in high speed and long distance networks. Through extensive analysis we focus on SQUARE, one of the protocols in odd function congestion control. Without the need to revise the current end-to-end architecture, SQUARE is shown to be efficient when there is bandwidth available, to be fair when many flows compete with each other for the same bottleneck, to be friendly when deployed with the conventional TCP, to be robust when there are oscillations in the network.
Adaptation of service-based business processes by context-aware replanning

Service-based business processes are typically used by organizations to achieve business goals through the coordinated execution of a set of activities implemented as services and service compositions. Since they are executed in dynamic, open and non-deterministic environments, business processes often need to be adapted to exogenous context changes and execution problems. In this paper we provide an adaptation approach that can automatically adapt business processes to run-time context changes that impede achievement of a business goal. We define a formal framework that adopts planning techniques to automatically derive necessary adaptation activities on demand. The adaptation consists in identifying recovery activities that guarantee that the execution of a business process can be successfully resumed and, as a consequence, the business goals are achieved. The solution proposed is evaluated on a real-world scenario from the logistics domain.
Sexual Behavior Induction of c-Fos in the Nucleus Accumbens and Amphetamine-Stimulated Locomotor Activity Are Sensitized by Previous Sexual Experience in Female Syrian Hamsters

Dopamine transmission in the nucleus accumbens can be activated by drugs, stress, or motivated behaviors, and repeated exposure to these stimuli can sensitize this dopamine response. The objectives of this study were to determine whether female sexual behavior activates nucleus accumbens neurons and whether past sexual experience cross-sensitizes neuronal responses in the nucleus accumbens to amphetamine. Using immunocytochemical labeling, c-Fos expression in different subregions (shell vs core at the rostral, middle, and caudal levels) of the nucleus accumbens was examined in female hamsters that had varying amounts of sexual experience. Female hamsters, given either 6 weeks of sexual experience or remaining sexually naive, were tested for sexual behavior by exposure to adult male hamsters. Previous sexual experience increased c-Fos labeling in the rostral and caudal levels but not in the middle levels of the nucleus accumbens. Testing for sexual behavior increased labeling in the core, but not the shell, of the nucleus accumbens. To validate that female sexual behavior can sensitize neurons in the mesolimbic dopamine pathway, the locomotor responses of sexually experienced and sexually naive females to an amphetamine injection were then compared. Amphetamine increased general locomotor activity in all females. However, sexually experienced animals responded sooner to amphetamine than did sexually naive animals. These data indicate that female sexual behavior can activate neurons in the nucleus accumbens and that sexual experience can cross-sensitize neuronal responses to amphetamine. In addition, these results provide additional evidence for functional differences between the shell and core of the nucleus accumbens and across its anteroposterior axis.