Miracle-dz/UniFAR-FTUs huggingface dataset:
Social Skills Training for Children and Youth with Emotional and Behavioral Disorders: Validity Considerations and Future Directions

This article provides an analysis of the current knowledge base of social skills training (SST) with students with, or at risk for, Emotional and Behavioral Disorders (EBD). This knowledge base is evaluated with respect to issues regarding construct, internal, external, and social validity of the SST literature. Research syntheses investigating construct validity suggest that the three domains of social interaction, prosocial behavior, and social-cognitive skills adequately represent the social skills construct. Internal validity analyses based on the results of six meta-analyses suggested that SST is an effective intervention strategy for students with EBD, showing a 64% improvement rate relative to controls using the Binomial Effect Size Display. External validity analyses showed that SST is effective across a broad range of behavioral difficulties, such as aggression externalizing behaviors, internalizing behaviors, and antisocial behavior patterns. Some weaknesses were noted in the social validity of SST outcome measures, and recommendations are made for improvement in this area. Overall, SST is an effective and essential part of a comprehensive intervention program for students with EBD.
Glucagon inhibits ghrelin secretion in humans.

OBJECTIVE It is well known that i.m. glucagon administration stimulates GH and cortisol release in humans, although the mechanisms are unclear. These effects are similar to those described for ghrelin on somatotroph and corticotroph function. The aim of the present study was to investigate the role of ghrelin in mediating the stimulatory effects of glucagon and to evaluate the effect of glucagon on ghrelin secretion. DESIGN AND METHODS We studied the endocrine and metabolic response to i.m. glucagon administration in 24 subjects (14 men, 10 women; age 19-65 years; body mass index, 25.3 +/- 1 kg/m(2)), who were shown to have an intact anterior pituitary function as evaluated before enclosure. RESULTS Serum ghrelin concentrations fell significantly at 30, 60, 120 and 180 min after glucagon administration (means +/- s.e.m.; baseline, 377.9 +/- 34.5 pg/ml; nadir, 294.6 +/- 28.3 pg/ml (60 min); P < 0.01). Conversely, i.m. glucagon elicited an increase in GH (baseline, 1.5 +/- 0.4 microg/l; peak, 14.2 +/- 2.7 microg/l (180 min); P < 0.01) and cortisol concentrations (baseline, 452.6 +/- 35.2 nmol/l; peak, 622.1 +/- 44 nmol/l (180 min); P < 0.01). The changes in ghrelin concentration at both 120 and 180 min were still significant after correction for glucose and insulin (P < 0.05). CONCLUSIONS We show that i.m. glucagon decreases ghrelin significantly. Therefore, the already known stimulatory effects of i.m. glucagon on cortisol and GH are not mediated by a change in ghrelin concentrations. The mechanisms underlying the ghrelin suppression after i.m. glucagon are unlikely to include glucose or insulin variations and need to be further elucidated.
Influence of Tillage on Adult and Immature Pea Leaf Weevil (Coleoptera: Curculionidae) Densities in Pea

ABSTRACT The pea leaf weevil, Sitona lineatus (L.) (Coleoptera: Curculionidae), has been a major pest of pea, Pisum sativum L. , in eastern Washington and northern Idaho since its introduction to the region in the early 1970s. Eggs are deposited in the spring on the soil surface and first instars hatch and move to pea root nodules, where larvae feed before they pupate and adults emerge in mid- to late summer. No-tillage practices are known to reduce pea leaf weevil colonization in pea, but the effects of tillage on larval densities and subsequent adult emergence have not been examined. During 2005, 2006, and 2007, we compared densities of colonizing adult and immature pea leaf weevils on pea plots grown using conventional tillage and no-tillage. In 2005 and 2006, emergence of adult pea leaf weevil was monitored in the same plots. Densities of colonizing adult and immature pea leaf weevil were significantly higher in conventional tillage plots. Larvae in conventional tillage were further along in development than larvae in no-tillage plots during June and July. Densities of emerging adult pea leaf weevil were significantly greater from conventional tillage than no-tillage plots. Based on densities of colonizing and subsequent emerging adults, survival of weevils from egg through adult was greater in conventional tillage plots, Soils under no-tillage are cooler, resulting in later emergence of the pea crop and delayed root nodule development, possibly affecting the ability of first-instar pea leaf weevil to locate host plant roots. Our results indicate no-tillage fields are less suitable for pea leaf weevil colonization and survival than conventional tillage fields.
Studies on the taxonomy of the Myxobacterales. I. Record of Canadian isolates and survey of methods.

One hundred and sixty-seven pure cultures have been isolated from among 338 myxobacteria obtained from Essex county (Ontario) soil samples by various methods. The fruiting body characteristics used in the characterization of the Myxobacterales have been found to be variable and unstable. However, the order may be considered to consist of two broad groups based on vegetative cell morphology and the formation of microcysts. A proposal is made to divide the genus Chondromyces into Stigmatella and Chondromyces and to assign the latter to the family Sorangiaceae. A number of biochemical tests have been found useful in identification and some are correlated with morphological features.The paper includes 42 color photographs as an aid for other investigators in the identification of the Myxobacterales.
Silicon substituted hydroxyapatites. A method to upgrade calcium phosphate based implants

Silicon substituted hydroxyapatites (SiHA) are among the most interesting bioceramics in the field of bioactive bone implants. Silicon incorporation into the apatite structure results in materials with comparable biocompatibility and mechanical properties, but with improved bioactive behaviour. The higher bioactivity promotes the reaction between bone and implant, leading to excellent osteointegration and ensuring the implant success. The improved properties of SiHA compared to pure HA have been demonstrated by both in vitro and in vivo tests. In this feature article, the main synthesis methods and results are reviewed for different SiHA. Finally, the role of Si is considered from the point of view of materials science at the crystallographic, micro structural and surface chemistry levels.
Analysis of Genetic Heterogeneity in Chlamydia trachomatis Clinical Isolates of Serovars D, E, and F by Amplified Fragment Length Polymorphism

ABSTRACT Amplified fragment length polymorphism (AFLP) fingerprinting of clinical isolates of Chlamydia trachomatis serovars D, E, and F showed a low percentage of genetic heterogeneity, but clear differences were found. Isolates from index patients and partners had identical AFLP patterns and AFLP markers. Characterization of these AFLP markers could give more insight into the differences in virulence and clinical course of C. trachomatis infections.
Postnatal Development of Dopamine D1-Like Receptors in Rat Cortical and Striatolimbic Brain Regions: An Autoradiographic Study

Postnatal development of dopamine D<sub>1</sub>-like (D<sub>1</sub>/D<sub>5</sub>) receptors in rat caudate-putamen (CPu), nucleus accumbens (NAc), hippocampus, frontal and entorhinal cerebral cortex was assessed between postnatal days (PD) 7–60 by in vitro receptor autoradiography. Density of [<sup>3</sup>H]SCH-23390 binding to D<sub>1</sub>-like receptors increased from PD-7 to a peak at PD-28 in CPu (11-fold) and NAc (23-fold), then declined by 20–40% in both regions over PD-35–60, to adult levels. In hippocampus, frontal and entorhinal cortex, D<sub>1</sub>-like receptors increased by lesser amounts (3- to 4-fold) from PD-7 to stable, maximal adult levels at PD-60. Evidently, excess D<sub>1</sub>-like receptors were eliminated during maturation of CPu and NAc, but not in the other forebrain regions. Postnatal D<sub>1</sub>-like receptor development in rat forebrain paralleled that of D<sub>2</sub>- and D<sub>4</sub>-like receptors in the same regions.
Smoking and interstitial lung disease. The effect of cigarette smoking on the incidence of pulmonary histiocytosis X and sarcoidosis.

Cigarette smoking produces marked alterations in the lung parenchyma and in the population of immune and inflammatory cells present in the lower respiratory tract. These cigarette-induced changes appear to influence the incidence of two different interstitial lung diseases, histiocytosis X and sarcoidosis. Smoking is a strong risk factor for the development of pulmonary histiocytosis X, since the incidence of smoking is very high among patients with histiocytosis X: 90% of the patients with histiocytosis X were smokers; 46% of the controls were smokers (p less than .001). In contrast, smoking appears to reduce the incidence of sarcoidosis: 31% of the patients with sarcoidosis were smokers (p less than .05 compared to controls). In an effort to understand how cigarette smoking influences the incidence of these two disorders, we compared the numbers and types of immune and inflammatory cells recovered by bronchoalveolar lavage from nonsmoking and smoking controls and patients with histiocytosis X and sarcoidosis. Although nonsmoking patients with histiocytosis X did not have a significant increase in the number of alveolar macrophages recovered by lavage (p greater than .2 compared to normals), smoking patients had an increase in the number of alveolar macrophages similar to that observed in the control population. In contrast, the number of macrophages recovered from patients with sarcoidosis who smoked was considerably less than that observed in normal smokers (p less than .05 comparing patients with sarcoidosis and controls who smoked 1-20 cigarettes/day). This difference in the intensity of the cigarette-induced macrophage alveolitis observed in the two patient groups may be important in explaining the opposite effects of cigarette smoking on the incidence of histiocytosis X and sarcoidosis.
How homogenous are currency crises? A panel study using multiple - response models

This paper presents formal evidence that currency episodes display heterogeneity in terms of their evolution, their impact on the inflicted economy and their links with financial, political and macroeconomic fundamentals. Limited-dependent variable models for ordered and unordered outcomes along with their heteroskedastic and random effects extensions are applied on a large panel of data comprising 40 years of monthly observations on 23 developed countries. Heterogeneity, complemented by indications of self-fulfilling expectations and noise, suggest that time and region specific predictive approaches and policy responses are more useful than trying to base analysis and policy decisions on more general patterns. Results are established with formal specification tests.
Control of a buck inverter for grid-connected PV systems: a digital and sliding mode control approach

This work describes the analysis, modeling and design of a buck-based inverter control for grid-connected photovoltaic (PV) systems. On one hand a linear digital voltage controller is designed from a large-signal linear sampled-data model of the system to maximize the steady-state input-output energy transfer ratio. On the other hand, a sliding-mode current controller is also designed to assure a unity power factor. The achievement of the DC-AC conversion and the efficient PVs energy extraction are validated with simulation results.
Monitoring of actuation conditions in a micro-turbo-generator

This paper presents the theory and implementation of an integrated sensing technique for the real-time measurement of applied actuation conditions in a micro-turbo-generator. The device is composed of a microturbine rotor with magnetic components and a stator with planar coils for electromagnetic induction. While the rotor is actuated with pressurized nitrogen, the induced voltages are extracted to generate and deliver electrical power as well as to monitor the pneumatic actuation parameters. It is demonstrated that the rotor speed, applied gas flow rate, and pressure show repeatable high linearity with respect to voltage frequency and amplitude in different devices. Sensitivity values of 83 Hz/krpm, 140 Hz/slm, and 1428 Hz/psi together with R2 values larger than 0.97 are achieved. The integrated sensing technique presented in this paper will eliminate the need for external sensing components in continuous device screening, and lead to closed-loop control for autonomous tuning of desired operating conditions in rotary microgenerators.
Growth response and acclimation of CO2 exchange characteristics to elevated temperatures in tropical tree seedlings

Predictions of how tropical forests will respond to future climate change are constrained by the paucity of data on the performance of tropical species under elevated growth temperatures. In particular, little is known about the potential of tropical species to acclimate physiologically to future increases in temperature. Seedlings of 10 neo-tropical tree species from different functional groups were cultivated in controlled-environment chambers under four day/night temperature regimes between 30/22 °C and 39/31 °C. Under well-watered conditions, all species showed optimal growth at temperatures above those currently found in their native range. While non-pioneer species experienced catastrophic failure or a substantially reduced growth rate under the highest temperature regime employed (i.e. daily average of 35 °C), growth in three lowland pioneers showed only a marginal reduction. In a subsequent experiment, three species (Ficus insipida, Ormosia macrocalyx, and Ochroma pyramidale) were cultivated at two temperatures determined as sub- and superoptimal for growth, but which resulted in similar biomass accumulation despite a 6°C difference in growth temperature. Through reciprocal transfer and temperature adjustment, the role of thermal acclimation in photosynthesis and respiration was investigated. Acclimation potential varied among species, with two distinct patterns of respiration acclimation identified. The study highlights the role of both inherent temperature tolerance and thermal acclimation in determining the ability of tropical tree species to cope with enhanced temperatures.
Sorafenib with or without everolimus in patients with advanced hepatocellular carcinoma (HCC): a randomized multicenter, multinational phase II trial (SAKK 77/08 and SASL 29).

BACKGROUND Sorafenib (S), a multitargeted tyrosine kinase inhibitor, is the standard of care for first-line systemic treatment of advanced hepatocellular carcinoma (HCC). Everolimus (E) is a potent inhibitor of mTOR, a pathway frequently activated in HCC. Preclinical data suggest that the combination S + E has additive effects compared with single-agent S. PATIENTS AND METHODS Patients with unresectable or metastatic HCC and Child-Pugh ≤7 liver dysfunction were randomized to receive daily S 800 mg alone or with E 5 mg until progression or unacceptable toxicity. The primary end point was progression-free survival at 12 weeks (PFS12). The secondary end points included response rate, PFS, time to progression (TTP), overall survival (OS), duration of disease stabilization (DDS), safety, and quality-of-life (QoL) assessments. RESULTS A total of 106 patients were randomized: 46 patients received S and 60 patients received S + E. Ninety-three patients were assessable for the primary end point and 105 patients for the safety analysis. The PFS12 rate was 70% [95% confidence interval (CI) 54-83] and 68% (95% CI 53-81) in patients randomized to S and S + E, respectively. The RECIST (mRECIST) response rate was 0% (23%) in the S arm and 10% (35%) in the S + E arm. Median PFS (6.6 versus 5.7 months), TTP (7.6 versus 6.3 months), DDS (6.7 versus 6.7 months), and OS (10 versus 12 months) were similar in the S and S + E arms, respectively. Grade 3/4 adverse events occurred in 72% and 86% of patients in arm S and arm S + E, respectively. Patients had similar QoL scores over time, except for a greater worsening in physical well-being and mood in the arm S + E. CONCLUSIONS No evidence was found that S + E improves the efficacy compared with S alone. Combining 5 mg E with full-dose S is feasible, but more toxic than S alone. Further testing of this drug combination in molecularly unselected HCCs appears unwarranted. CLINICALTRIALSGOV NCT01005199.
Stability analysis of a class of MIMO fuzzy control systems

This paper suggests a new stability analysis approach dedicated to a class of fuzzy control systems controlling multi input-multi output (MIMO) nonlinear processes by means of Takagi-Sugeno fuzzy logic controllers. The approach is based on LaSalle's global invariant set theorem, and an original stability theorem offers sufficient stability conditions. The applicability and efficiency of the theoretical results are illustrated by a MIMO case study dealing with the fuzzy control of a spherical three tank system.
Shaping the zebrafish notochord

Promptly after the notochord domain is specified in the vertebrate dorsal mesoderm, it undergoes dramatic morphogenesis. Beginning during gastrulation, convergence and extension movements change a squat cellular array into a narrow, elongated one that defines the primary axis of the embryo. Convergence and extension might be coupled by a highly organized cellular intermixing known as mediolateral intercalation behavior (MIB). To learn whether MIB drives early morphogenesis of the zebrafish notochord, we made 4D recordings and quantitatively analyzed both local cellular interactions and global changes in the shape of the dorsal mesodermal field. We show that MIB appears to mediate convergence and can account for extension throughout the dorsal mesoderm. Comparing the notochord and adjacent somitic mesoderm reveals that extension can be regulated separately from convergence. Moreover, mutational analysis shows that extension does not require convergence. Hence, a cellular machine separate from MIB that can drive dorsal mesodermal extension exists in the zebrafish gastrula. The likely redundant control of morphogenesis may provide for plasticity at this critical stage of early development.
Identifying gene‐gene interactions using penalized tensor regression

Gene‐gene (G×G) interactions have been shown to be critical for the fundamental mechanisms and development of complex diseases beyond main genetic effects. The commonly adopted marginal analysis is limited by considering only a small number of G factors at a time. With the “main effects, interactions” hierarchical constraint, many of the existing joint analysis methods suffer from prohibitively high computational cost. In this study, we propose a new method for identifying important G×G interactions under joint modeling. The proposed method adopts tensor regression to accommodate high data dimensionality and the penalization technique for selection. It naturally accommodates the strong hierarchical structure without imposing additional constraints, making optimization much simpler and faster than in the existing studies. It outperforms multiple alternatives in simulation. The analysis of The Cancer Genome Atlas (TCGA) data on lung cancer and melanoma demonstrates that it can identify markers with important implications and better prediction performance.
Epicardial and Endocardial Activation During Sustained Ventricular Tachycardia in Man

Ventricular activation during ventricular tachycardia was studied by intraoperative epicardial and endocardial mapping in 21 patients with coronary artery disease and previous myocardial infarction who underwent operation for recurrent ventricular tachycardia. Twenty-nine morphologically distinct tachycardias were mapped; 18 tachycardias had a right bundle branch block morphology and 11 had a left bundle branch block morphology. After cannulation for bypass, the tachycardias were induced and electrograms were recorded at 55-75 epicardial sites. After starting cardiopulmonary bypass, the infarction was incised and electrograms were recorded at 28-55 left ventricular endocardial sites during ventricular tachycardia. All mapping data were analyzed with three simultaneously recorded ECG leads and two reference electrograms. Earliest activation in all tachycardias occurred on the endocardial surface of the infarction. In each tachycardia, endocardial electrical activity was recorded before the onset of the QRS complex. Earliest epicardial activation in the 29 tachycardias occurred 10 msec after the onset of the QRS complex. Epicardial breakthrough occurred on the right (19 tachycardias) as well as the left ventricle (10 tachycardias). We conclude that ventricular tachycardia associated with ischemic heart disease originates near the endocardial surface of the left ventricle along the border of the infarction and that epicardial mapping alone is insufficient to identify the site of origin of these tachycardias.
Automatic Extraction of Implicit Interpretations from Modal Constructions

This paper presents an approach to extract implicit interpretations from modal constructions. Importantly, our approach uses a deterministic procedure to normalize eventuali-ties and generate potential interpretations. An annotation effort demonstrates that these interpretations are intuitive to humans and most modal constructions convey at least one interpretation. Experimental results show that the task is challenging but can be automated
DOUBLE-BLIND TRIAL OF CHOLESTYRAMINE IN POST-VAGOTOMY DIARRHOEA

The effect of cholestyramine in post-vagotomy diarrhoea has been assessed under double-blind conditions. Cholestyramine produced a significant improvement in frequency, urgency, and consistency of stool as well as episodic diarrhoea. Faecal bile acid excretion was significantly higher in the post-vagotomy group when compared with normal controls. These findings confirm the effectiveness of cholestyramine and support the concept of a bile acid mediated aetiology in post-vagotomy diarrhoea.
Towards an automated system for intelligent screening of candidates for recruitment using ontology mapping (EXPERT)

Many e-recruitment tools for recruiting candidates for jobs have significantly spread in recent years. Companies often receive resumes from candidates using e-recruitment tools or via job portal for each job posting and manually short list qualified applicants. The existing e-recruitment tools have been mainly used for the storage of applicant contact data. In this paper, we present EXPERT, an intelligent tool for screening candidates for recruitment using ontology mapping. EXPERT has three phases in screening candidates for recruitment. In first phase, the system collects candidates' resumes and constructs ontology document for the features of the candidates. Job openings/job requirements are represented as ontology in the second phase and in third phase, EXPERT maps the job requirement ontology onto the candidate ontology document and retrieves the eligible candidates. Experiment results show that this model improves the accuracy of matching candidates with job requirement.