Miracle-dz/UniFAR-FTUs huggingface dataset:
Infant deaths associated with human parechovirus infection in Wisconsin.

BACKGROUND From December 1987 through August 2004, lung tissue, nasopharyngeal swabs, and colon swab specimens obtained during 1263 autopsies of infants and young children were examined to assess the role of viruses in deaths of children aged <2 years. METHODS Multiple cell cultures were used to isolate viruses. With 4 exceptions, virus isolates were identified by neutralization, immunofluorescence assay, or enzyme immunoassay. RNA extracted from these 4 isolates and associated autopsy specimens was tested using parechovirus-specific real-time polymerase chain reaction (RT-PCR) and sequencing assays. RESULTS Specimens from 426 (34%) autopsies were positive for at least 1 virus; enteroviruses and adenoviruses were the most commonly identified. Human parechoviruses (HPeVs) were identified antigenically in isolates from 18 decedents (all HPeV type 1) and by RT-PCR in isolates and multiple autopsy specimens from 4 decedents with untypeable virus isolates. Sequencing of the VP1 region identified these 4 HPeVs as HPeV type 3 (n = 3) and HPeV type 6 (n = 1). Despite the detection of HPeV, the deaths of decedents 3 and 4 were determined to have been from noninfectious causes. CONCLUSIONS These are the first confirmed HPeV type 3 and HPeV type 6 detections in the United States. This is also the initial report of fatal cases with associated HPeV type 3 infection. These results support prior findings associating HPeVs with serious disease in young children. Clinical testing for HPeVs and routine HPeV surveillance by public health laboratories will help determine the burden of disease caused by HPeVs.
Dynamics of roll waves

Shallow-water equations with bottom drag and viscosity are used to study the dynamics of roll waves. First, we explore the effect of bottom topography on linear stability of turbulent flow over uneven surfaces. Low-amplitude topography is found to destabilize turbulent roll waves and lower the critical Froude number required for instability. At higher amplitude, the trend reverses and topography stabilizes roll waves. At intermediate topographic amplitude, instability can be created at much lower Froude numbers due to the development of hydraulic jumps in the equilibrium flow. Second, the nonlinear dynamics of the roll waves is explored, with numerical solutions of the shallow-water equations complementing an asymptotic theory relevant near onset. We find that trains of roll waves undergo coarsening due to waves overtaking one another and merging, lengthening the scale of the pattern. Unlike previous investigations, we find that coarsening does not always continue to its ultimate conclusion (a single roll wave with the largest spatial scale). Instead, coarsening becomes interrupted at intermediate scales, creating patterns with preferred wavelengths. We quantify the coarsening dynamics in terms of linear stability of steady roll-wave trains.
Omitting Refresh: A Case Study for Commodity and Wide I/O DRAMs

Dynamic Random Access Memories (DRAM) have a big impact on performance and contribute significantly to the total power consumption in systems ranging from mobile devices to servers. Up to half of the power consumption of future high density DRAM devices will be caused by refresh commands. Moreover, not only the refresh rate does depend on the device capacity, but it strongly depends on the temperature as well. In case of 3D integration of MPSoCs with Wide I/O DRAMs the power density and thermal dissipation are increased dramatically. Hence, in 3D-DRAM even more DRAM refresh operations are required. To master these challenges, clever DRAM refresh strategies are mandatory either on hardware or on software level using new or already available infrastructures and implementations, such as Partial Array Self Refresh (PASR) or Temperature Compensated Self Refresh (TCSR). In this paper, we show that for dedicated applications refresh can be disabled completely without or with negligible impact on the application performance. This is possible if it is assured that either the lifetime of the data is shorter than the currently required DRAM refresh period or if the application can tolerate bit errors to some degree in a given time window.
Handling requirements dependencies in agile projects: A focus group with agile software development practitioners

Agile practices on requirements dependencies are a relatively unexplored topic in literature. Empirical studies on it are scarce. This research sets out to uncover concepts that practitioners in companies of various sizes across the globe and in various industries, use for dealing with requirements dependencies in their agile software projects. Concepts were revealed through online focus group research, using an adapted forum for discussion, and grounded theory to analyze the responses. Our study resulted in the following findings: (1) requirements dependencies occur in agile projects and are important to these projects' success just as this is known for `traditional' software projects'; (2) requirements dependencies (i) were considered and treated as part of risk management, (ii) were deemed a responsibility of the individual team members, and (iii) mostly did affect project planning; (3) continuous communication and collaboration - two essential features of any agile method, were found critical to mitigating the risks due to dependencies; (4) a hybrid approach to architecture between agile and plan-driven methods was perceived to yield maximum scalability and help coping with dependencies; (5) `cross-cutting concerns', a category of dependencies, were not uniformly understood in an agile context and require more research.
MASS DISTRIBUTION IN THE CENTRAL FEW PARSECS OF OUR GALAXY[Author's correction]

We estimate the enclosed mass profile in the central 10 pc of the Milky Way by analyzing the infrared photometry and the velocity observations of dynamically relaxed stellar population in the Galactic center. HST/NICMOS and Gemini Adaptive Optics images in the archive are used to obtain the number density profile, and proper motion and radial velocity data were compiled from the literature to find the velocity dispersion profile assuming a spherical symmetry and velocity isotropy. From these data, we calculate the enclosed mass and density profiles in the central 10 pc of the Galaxy using the Jeans equation. Our improved estimates can better describe the exact evolution of the molecular clouds and star clusters falling down to the Galactic center, and constrain the star formation history of the inner part of the Galaxy. Subject headings: Galaxy: center — Galaxy: structure — Galaxy: kinematics and dynamics
A survey of Cyber-Physical Systems

Cyber-Physical Systems (CPSs) are characterized by integrating computation and physical processes. The theories and applications of CPSs face the enormous challenges. The aim of this work is to provide a better understanding of this emerging multi-disciplinary methodology. First, the features of CPSs are described, and the research progresses are summarized from different perspectives such as energy control, secure control, transmission and management, control technique, system resource allocation, and model-based software design. Then three classic applications are given to show that the prospects of CPSs are engaging. Finally, the research challenges and some suggestions for future work are in brief outlined.
Overweight and obese anovulatory patients with polycystic ovaries: parallel improvements in anthropometric indices, ovarian physiology and fertility rate induced by diet.

BACKGROUND This prospective study evaluated the effect of weight reduction on anthropometric indices and ovarian morphology in anovulatory overweight patients with polycystic ovary syndrome (PCOS). METHODS Thirty-three anovulatory overweight patients with PCOS were enrolled in the study. All had patent Fallopian tubes and chronic anovulation: 27 of them were oligo-amenorrhoeic. The partners were normospermic. Patients were prescribed a 1200 kcal/day diet, and physical exercise was recommended. Anthropometric indices and ovarian imaging parameters were assessed at baseline and after weight loss of 5 and 10%. RESULTS Twenty-five patients (76%) lost at least 5% of their body weight. Eleven of these patients (33%) reached a 10% decrease in weight. Waist circumference at the umbilical level, hip circumference, four skin folds, body mass index and fatty mass ratio were significantly reduced after 5 and 10% weight loss. Ovarian morphology changed during the diet: we observed a significant reduction in ovarian volume and in the number of microfollicles per ovary. Among the 27 patients with oligo-amenorrhoea, 18 had a resumption of regular cycles and 15 experienced spontaneous ovulation; 10 spontaneous pregnancies occurred in patients who lost at least 5% of their weight. CONCLUSIONS Weight loss through a controlled low-calorie diet improves anthropometric indices in obese PCOS patients, reduces ovarian volume and microfollicle number and can restore ovulatory cycles, allowing spontaneous pregnancy.
Diversity and geographic distribution of the indigenous and exotic parasitoids of the olive fruit fly, Bactrocera oleae (Diptera: Tephritidae), in Southern France.

The olive fruit fly, Bactrocera oleae (Dipt., Tephritidae), is the most important pest of olive crops in the world. Economic losses associated to the limited efficiency of pesticides and natural regulation require the development of new alternatives. A classical biological control program was thus implemented in 2007 in France with two main objectives: (1) test the efficiency of a new exotic parasitoid, Psyttalia lounsburyi (Hym., Braconidae) on the olive fruit fly populations and (2) understand how intraspecific hybridization could affect the demographic success of exotic biocontrol agents and, more generally, invasive species. In 2008, more than 43,000 P. lounsburyi were consequently introduced in 60 sites located in Southern France, covering the whole geographic distribution of olive crops in this country. The pluri-annual surveys realised between 2007 and 2010 gave the opportunity to better document the dynamics of olive fruit fly populations as well as the associated communities of parasitoids. Main results on these two topics are outlined here in a view to stimulate collaborative research and more precisely document the community ecology of B. oleae and its natural enemies in the Mediterranean area and elsewhere. (Resume d'auteur)
Ultra-Fast Optimal Pathfinding without Runtime Search

Pathfinding is important in many applications, including games, robotics and GPS itinerary planning. In games, most pathfinding methods rely on runtime search. Despite numerous enhancements introduced in recent years, runtime search has the disadvantage that, in bad cases, most parts of a map need to be explored, causing a time performance degradation. In this work we explore a significantly different approach to pathfinding, eliminating the need for runtime search. Optimal paths between all pairs of locations are pre-computed. Since straightforward ways to store pre-computed paths are prohibitively expensive even for maps of moderate size, pre-computed data are compressed, reducing the memory requirements dramatically. At runtime, pathfinding is very fast, as it requires visiting only the locations on an optimal path. In each location, a quick computation provides the next move along the optimal path. We demonstrate the effectiveness of this approach on Baldur's Gate game maps. The compression factor reaches two orders of magnitude, bringing the memory requirements down to reasonable values. Compared to A* search, the runtime speedup reaches and even exceeds two orders of magnitude. When averaged over paths of similar cost, the speedup reaches a value of 700 in our experiments.
On the combination of relative clustering validity criteria

Many different relative clustering validity criteria exist that are very useful as quantitative measures for assessing the quality of data partitions. These criteria are endowed with particular features that may make each of them more suitable for specific classes of problems. Nevertheless, the performance of each criterion is usually unknown a priori by the user. Hence, choosing a specific criterion is not a trivial task. A possible approach to circumvent this drawback consists of combining different relative criteria in order to obtain more robust evaluations. However, this approach has so far been applied in an ad-hoc fashion only; its real potential is actually not well-understood. In this paper, we present an extensive study on the combination of relative criteria considering both synthetic and real datasets. The experiments involved 28 criteria and 4 different combination strategies applied to a varied collection of data partitions produced by 5 clustering algorithms. In total, 427,680 partitions of 972 synthetic datasets and 14,000 partitions of a collection of 400 image datasets were considered. Based on the results, we discuss the shortcomings and possible benefits of combining different relative criteria into a committee.
Creating an Immigrant-Friendly Society—What Drives Feelings Toward Immigrants?

ABSTRACT The number of individuals currently living in a country other than the one in which they were born peaked at more than 244 million in 2015. This makes the global society a culturally and racially diverse one. Although unpopular with some residents, immigrants are the reality of contemporary society. This study discusses immigration as a global phenomenon and the creation of immigrant-friendly society as a necessity. The study utilizes data from the 2014 General Social Survey on American attitudes toward immigrants to create the feelings toward immigrants (FTI) index and investigates the determinants of the feelings toward immigrants in the United States. The study finds that college education, income, political views, citizens, and residing in the West and the Northeast United States affect feelings toward immigrants. Interestingly, the study reveals that college education enhances the positive perception of liberals and moderates the negative views that conservatives and citizens might have. The study concludes that policymakers seeking to create immigrant-friendly society should focus on the above factors rather than race, attendance, and participation at religious events and other variables that were not significant.
Downregulation of HIF-1α inhibits the proliferation and invasion of non-small cell lung cancer NCI-H157 cells

Lung cancer, specifically non-small cell lung cancer (NSCLC), is the leading cause of cancer-associated mortality in the world. In previous years, almost no significant advancements have been made towards the molecular characterization of NSCLC, which highlights the requirement for novel target genes. Hypoxia inducible factor-1α (HIF-1α) is known to be essential in tumorigenesis, as it regulates the expression of numerous factors that are involved in angiogenesis, cellular proliferation and apoptosis. However, no direct association between HIF-1α and NSCLC treatment has previously been established. The aim of the present study was to characterize the effect of HIF-1α on NSCLC and to explore the possible mechanism. Additionally, HIF-1α small interfering (si)RNA and diamminedichloroplatinum (DDP) were used in combination to explore the combined effects on NSCLC cells. Lung carcinoma NCI-H157 cells were treated with HIF-1α small interfering (si)RNA, 5 µg/ml DDP or a combination of the two, and the proliferation, apoptosis and invasion ability of the cells were detected using a cell counting kit-8 assay, Annexin V/propidium iodide staining and a Transwell assay, respectively. In addition, the protein levels of caspase-3/9, anti-apoptotic protein B-cell lymphoma-2 (Bcl-2), vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), phosphoinositide 3-kinase (PI3K), phosphorylated (p-)PI3K, protein kinase B (AKT), p-AKT, extracellular signal-regulated kinase (ERK) and p-ERK were detected using western blot analysis. Similar to DPP treatment, HIF-1α siRNA treatment may reduce cell proliferation and the invasiveness of tumor cells while promoting apoptosis. Additionally, HIF-1α siRNA may increase the levels of the apoptotic proteins caspases 3 and 9 and inhibit the expression of Bcl-2. These anti-tumor effects may be acting through the VEGF/PEDF, PI3K/AKT and Raf/mitogen-activated protein kinase kinase/ERK signaling pathways. The effects of HIF-1α siRNA may be strengthened by DDP. The present data indicated that HIF-1α siRNA is important in the inhibition of NSCLC cells. Additionally, the effects of HIF-1α siRNA may be strengthened by DDP, which suggests that HIF-1α siRNA may be combined with DDP for the treatment of tumors.
Sur le groupe d'interpolation

We study the interpolation group whose elements are suitable pairs of formal power series. This group has a faithful representation into infinite lower triangular matrices and carries thus a natural structure as a Lie group. The matrix exponential between its Lie algebra and its matrix representation gives rise to a function with interesting properties extending the usual exponential function to two variables (which are formal power series) We finish with an application to enumerative combinatorics and the description of an algebra which generalizes the interpolation group.
The Impact of Disturbed Sleep on Attention, Working Memory, and Reaction Time Tasks in Children with ADHD

Attention deficit/hyperactivity disorder is the most commonly diagnosed neurodevelopmental/psychiatric condition in childhood (CDC; Gruber, 2009). Disturbances in sleep can create a variety of impairments, both cognitive and behavioral, and may negatively affect attention, memory, visuo-spatial abilities, sustained attention and divergent intelligence (creativity) (Stores, 1999). The aim of the present study was to examine the role that sleep disturbances had on the cognitive performance of children with ADHD. Specifically, the possible relationship between poor sleep and children’s performance on working memory, attention and reaction time tasks and poor sleep wereexamined. Overall, in the current sample of 54 children who underwent a neuropsychological evaluation at an outpatient clinic, the presence of sleep disturbances was not predictive of performance on tasks of attention and reaction time and memory. Although these findings seem counter to the existing literature, possible explanations forthese discrepancies are provided.
KELEKATAN, HARGA DIRI DAN PENYESUAIAN SOSIAL PADA KORBAN PERUNDUNGAN

This study aims to investigate the correlation of attachment and self-esteem to social adjustment on victims of bullying. Bullying victims encounter adverse effects that can prolong until adulthood. They also experience poor social adjustment. Good social adjustment associated with self-esteem. A warm and rewarding parenting practices facilitate high self-esteem. Emotional closeness creates strong bonds. Therefore attachment influences the formation of a sense of security for the survival of the child’s life in the future. The study population is students who were also bullying victims. The participants were 50 students that were identified using purposive sampling technique. The Social Adjustment Scale, the Attachment Scale, and the Self-Esteem Scale were used to collect data. The results of multiple regression analysis indicated that attachment and self-esteem predict social adjustment on victims of bullying ( F (2,47) = 5,576; p = 0,007; R 2 = 0,192). Partially, attachment predicts social adjustment on victims of bullying ( F (1,48) = 5,201; p = 0,027; R 2 = 0,098) and self-esteem predicts social adjustment on victims of bullying ( F (1,48) = 10,713; p = 0,002; R 2 = 0,182).
Prevalence of Hypertension in Chinese Cities: A Meta-Analysis of Published Studies

Background Hypertension has been recognized as a health concern for developing countries. However, there are no current nationwide surveys on the prevalence of hypertension in China (the latest nationwide survey was ten years ago). The goal of this study was to estimate the pooled prevalence of hypertension in Chinese cities. Methods We systematically reviewed published epidemiologic studies on the prevalence of hypertension in Chinese cities through meta-analysis. We searched for studies published between January 2002 and June 2012 using PubMed and two Chinese electronic publication libraries. The keywords ‘hypertension’ and ‘prevalence’ were used. Before pooling prevalence of hypertension, all raw prevalence data was age adjusted to the 2010 China standard population. Prevalence estimates were stratified by sex and geographic area. Results 27 studies were identified with of a total of 195,027 study participants. The overall pooled prevalence of hypertension was 21.5% (19.4%, 23.6%). Subgroup analyses showed the following results north 25.8% (21.6%, 30.0%), south 20.4% (18.6%, 22.2%); male 22.2% (19.3%, 25.1%), female 19.9% (17.6%, 22.1%); large cities 18.9% (15.7%, 22.1%), medium-sized cities 24.6% (19.9%, 29.4%), small cities 20.6% (17.5%, 23.7%); study years in 2002–2006, 21.9% (18.9%, 24.8%), and study year in 2007–2011, 20.6% (17.3%, 23.9%). Conclusions Comparing data from several previous national hypertension surveys, the prevalence of hypertension is higher in cities than the Chinese national average. Subgroup studies also found a higher prevalence of hypertension in northern cities and among males. Also, the prevalence of hypertension in medium-sized and small cities is likely to increase faster than in large cities.
Asymptotic $L^4$ norm of polynomials derived from characters

Littlewood investigated polynomials with coefficients in $\{-1,1\}$ (Littlewood polynomials), to see how small their ratio of norms $||f||_4/||f||_2$ on the unit circle can become as $deg(f)\to\infty$. A small limit is equivalent to slow growth in the mean square autocorrelation of the associated binary sequences of coefficients of the polynomials. The autocorrelation problem for arrays and higher dimensional objects has also been studied; it is the natural generalization to multivariable polynomials. Here we find, for each $n > 1$, a family of $n$-variable Littlewood polynomials with lower asymptotic $||f||_4/||f||_2$ than any known hitherto. We discover these through a wide survey, infeasible with previous methods, of polynomials whose coefficients come from finite field characters. This is the first time that the lowest known asymptotic ratio of norms $||f||_4/||f||_2$ for multivariable polynomials $f(z_1,.,z_n)$ is strictly less than what could be obtained by using products $f_1(z_1). f_n(z_n)$ of the best known univariate polynomials.
How Do Older Persons Understand the Purpose and Relevance of Preventive Home Visits? A Study of Experiences after a First Visit

The aim of this study was to explore and describe older persons' experiences of their first Preventive Home Visit. Preventive Home Visits (PHV) are health services that aim to promote older persons' health, prevent functional decline, and reduce the need for comprehensive healthcare. The knowledge base to guide the design of effective PHV interventions is scarce. Studies that explore older persons' experiences of the first visit are essential, as compliance with the service is a prerequisite for positive outcomes. An explorative and descriptive design was applied. Qualitative research interviews with ten older persons who had received the first PHV the previous year were analysed with regard to manifest and latent content. The findings revealed that the understanding of the purpose of PHV varied. For some participants, the concepts and aims of health promotion and disease prevention were difficult to comprehend. The possibility to prepare for the visit was sought. All participants appreciated the service; the dialogue quality was good and a trusted municipal contact person provided security. To enhance compliance and ensure effective PHV, the invitation to the PHV service should include clearly stated aims and specific information about the first visit. An individualised, person-centred approach should be applied.