Miracle-dz/UniFAR-FTUs huggingface dataset:
On Interpreting the Regression Discontinuity Design as a Local Experiment

We discuss the two most popular frameworks for identification, estimation and inference in regression discontinuity (RD) designs: the continuity-based framework, where the conditional expectations of the potential outcomes are assumed to be continuous functions of the score at the cutoff, and the local randomization framework, where the treatment assignment is assumed to be as good as randomized in a neighborhood around the cutoff. Using various examples, we show that (i) assuming random assignment of the RD running variable in a neighborhood of the cutoff implies neither that the potential outcomes and the treatment are statistically independent, nor that the potential outcomes are unrelated to the running variable in this neighborhood; and (ii) assuming local independence between the potential outcomes and the treatment does not imply the exclusion restriction that the score affects the outcomes only through the treatment indicator. Our discussion highlights key distinctions between “locally randomized” RD designs and real experiments, including that statistical independence and random assignment are conceptually different in RD contexts, and that the RD treatment assignment rule places no restrictions on how the score and potential outcomes are related. Our findings imply that the methods for RD estimation, inference, and falsification used in practice will necessarily be different (both in formal properties and in interpretation) according to which of the two frameworks is invoked.
Hemimandibular Hyperplasia: Classification and Treatment Algorithm Revisited

AbstractHemimandibular hyperplasia (HH) is a developmental asymmetry characterized by three-dimensional enlargement of one half of the mandible. The hyperplastic side usually involves the condyle, condylar neck, ramus, and body, with the anomaly terminating abruptly at the symphysis. The malformation results in the clinical presentation of ipsilateral enlargement of the mandible and tilted occlusal plane, associated with a deviated chin to the contralateral side. Since the first case report of HH in the English literature in 1836, various terminology and classifications were used. In this study, the authors classified the patients into typical and atypical types of HH on the basis of clinical and radiologic observations in an effort to achieve a simplified and efficient surgical management on the basis of the severity of deformity. Accordingly, surgical treatments are designed respectively on the basis of the authors’ classification and treatment algorithm. In addition, in view of potential complications arising from condylectomy, none of the patients had undergone condylectomy as part of the surgical treatment. The authors present their experience on the basis of this proposed classification and treatment algorithm with functional and aesthetic outcomes as the end points of this study.
[Helping relationship].

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Torsional osteotomies of the femur

Various pathologies of the hip or knee, such as patellofemoral malalignment or femoroacetabular impingement may be caused by a femoral torsional deformity. When diagnosed and analyzed, it is treated by femoral torsional osteotomy. Thirty femoral torsional osteotomies in 25 patients were included, the principal symptoms were patellar dislocation in 15 patients, anterior knee pain in 17, and femoroacetabular impingement in two. A computed‐tomography‐based measurement of the torsional angle was performed in all patients. Japanese Knee Society score, Tegner activity score, Lysholm score, and visual analog scale score were determined before surgery and at follow‐up after 41 (6–113) months. Femoral internal torsion was on average 40.9° (29° − 66°; normal 24°). Surgical treatment consisted of a femoral external torsional osteotomy of on average 13.8° (5° − 26°). Tegner activity score increased non‐significantly (p‐value 0.326) from 3.57 to 3.71. Japanese Knee Society score improved significantly from 72 to 87 (p‐value 0.004) while Lysholm score rose significantly from 66 to 84 points (p‐value 0.004). Pain relief was demonstrated by a significant decrease in the VAS score from 5.6 to 2.4 (p‐value 0.007). No further patellar dislocation was reported. Torsional deformities of the femur frequently cause symptoms in the knee or hip joint. After thorough assessment and diagnostic investigation, a femoral external torsional osteotomy provides significant pain relief as well as patellofemoral stability. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:? –? , 2015.
Caecal intussusceptions in horses: a New Zealand perspective.

OBJECTIVE To establish the prevalence of intussusceptions involving the caecum in a population of horses admitted to a university hospital for colic. DESIGN Retrospective clinical study METHODS Medical records of all horses admitted to the Massey University Veterinary Teaching Hospital between 1991 and 2004 were examined for information of those horses diagnosed with an intussusception involving the caecum. RESULTS A total of 135 horses were admitted for colic surgery during the study period and 61 horses had a diagnosis of ileocaecal (37), caecocaecal (5) or caecocolic intussusception (19) made either at surgery or necropsy. Of the horses with ileocaecal intussusception, 32 had an incomplete hand-sewn ileocaecostomy without reduction and 29 survived to discharge. All the horses with caecocaecal intussusceptions were diagnosed preoperatively via rectal examination and/or transabdominal ultrasound: 2 were euthanased at surgery and 3 survived to discharge. In the 19 horses with caecocolic intussusceptions, manually reduction at surgery was performed in 6 and 5 of them survived to discharge. A typhlectomy was performed via a colotomy in 6 horses, 3 of which survived to discharge. CONCLUSIONS The high prevalence of intussusceptions involving the caecum seen at this referral centre may indicate a higher prevalence in New Zealand than is reported elsewhere in the world. CLINICAL RELEVANCE Intussusceptions involving the caecum should be considered as a differential diagnosis in horses presenting with chronic low-grade colic. Transabdominal ultrasound is useful for identifying caecocaecal and caecocolic intussusceptions. Hand-sewn side-to-side incomplete ileocaecostomy is a quick, effective and safe method of surgical treatment of ileocaecal intussusceptions.
JOSHUA M. SMYTH and ARTHUR A. STONE ECOLOGICAL MOMENTARY ASSESSMENT RESEARCH IN BEHAVIORAL MEDICINE

Behavioral medicine research often seeks to examine relatively complex theoretical models and clinical processes. Traditional designs, based on retrospective self-report in the natural environment or laboratory-based studies, cannot assess complex and temporally dynamic psychological, behavioral, and physiological processes in the natural environment. An alternate research approach, Ecological Momentary Assessment (EMA), provides a method to collect such data. This research approach and these data allow investigation of a number of research questions not amenable to other data collection methods. Examples of research questions uniquely suited for EMA data include, but are not limited to: (1) the comparison of retrospective data to momentary data; (2) evaluation of physiological and psychosocial processes in the natural environment; (3) the relation of symptoms and other disease processes to characteristics of the natural environment; and (4) examination of dynamic changes in psychosocial variables that may mediate improvement following treatment. Despite the strengths of EMA data, a number of challenges exist – including logistic, analytic, and interpretation problems – to the easy implementation of EMA approaches in behavioral medicine.
An Online, Mindfulness-Based, Cognitive-Behavioral Therapy for Female Sexual Difficulties: Impact on Relationship Functioning

This article presents the evaluation of an online treatment for female sexual difficulties as it relates to relationship functioning. Pursuing Pleasure was an online, mindfulness-based, cognitive behavioral therapy for female sexual difficulties. In Study 1, 26 women completed treatment and changes were compared with a waitlist control group (n = 31). In Study 2, 16 women from the control group then completed treatment. The authors did not use a control group in Study 2. Results demonstrated that both treatment groups observed significant improvements in sexual intimacy and communication, and emotional intimacy improved significantly in the Study 1 treatment group. Most improvements were maintained at follow-up.
Increased Connective Tissue Extracellular Matrix in the op/op Model of Osteopetrosis

Mice that are homozygous for the recessive osteopetrosis spontaneous mutation (op/op) develop severe osteopetrosis due to a defect in the production of macrophage colony-stimulating factor (M-CSF) and a deficiency in monocyte-derived osteoclasts. Our study describes a novel soft tissue finding in an osteopetrosis (B6C3Fe a/a-Csf1op/J) mouse model. Tissues were obtained from B6C3Fe a/a-Csf1op/J mice and age-matched wild-type mice, processed for hematoxylin and eosin sections, and comprehensive light microscopic tissue evaluation was performed. Mutant mice had characteristic traits of op/op deficiency including missing incisors and domed skulls. Histologically, the bone marrow cavity was effaced by interweaving thick bony trabeculae consistent with osteopetrosis. An increase in a finely granular, basophilic interstitial extracellular matrix (ECM) was observed in the subcutaneous connective tissue of the op/op mice when compared with controls. Histochemically, the ECM was negative with periodic acid Schiff and stained dark blue with alcian blue at a pH of 2.5, indicating that it is composed primarily of nonsulfated glycosaminoglycans (GAGs). This work suggests an increased ECM that is composed mainly of GAGs located in the subcutaneous tissue in op/op mice. This increase in ECM may be related to altered matrix production or turnover because of changes in M-CSF production.
Factors Affecting Alkaline Sodium Silicate Gelation for In-Depth Reservoir Profile Modification

Alkaline sodium silicate (Na-silicate) is environment-friendly and possesses water-like viscosity during the injection stage for in-depth reservoir treatment to enhance sweep efficiency. Gel setting time ( t g ) and gel strength are interrelated. Factors that accelerate t g are Na-silicate content (wt%), low pH, presence of divalent ions and temperature. Pressure drop across the gel accelerates syneresis; however, the gel appeared to remain intact. Presence of Ca 2+ and Mg 2+ ions is shown to increase gel strength. With a Na-silicate content of 4.5 wt%, for example, at a pH of 10.3 and a temperature of 20 °C, gel strength almost tripled and was reached about eight times faster at the combined tested concentration of 0.009 M, based on the average effect from the coexistence of both ions. Low-salinity water (LSW) has an ion composition of 25-fold diluted seawater, did not show precipitation, and could accordingly be a candidate for a pre-flush before the injection of a Na-silicate solution in the event of a field application. This is important since LSW for enhancing oil recovery is a popular method in oil industry. A suggested predictive tool (simple graphical method) to estimate the effect of different factors on gelation time and gel strength is presented.
Heterogeneous Information Network Embedding for Meta Path based Proximity

A network embedding is a representation of a large graph in a low-dimensional space, where vertices are modeled as vectors. The objective of a good embedding is to preserve the proximity between vertices in the original graph. This way, typical search and mining methods can be applied in the embedded space with the help of off-the-shelf multidimensional indexing approaches. Existing network embedding techniques focus on homogeneous networks, where all vertices are considered to belong to a single class.
What do we know about the movement abilities of children with Down syndrome

Introduction Many babies and young children with Down syndrome are late to reach the early motor milestones such as grasping, rolling, sitting, standing and walking. There is wide variability in progress, with some reaching these milestones as early as typically developing infants and some being particularly slow in achieving them. Most parents are advised that physiotherapy will help, but do we actually know the reasons for this slower progress that will provide guidelines for effective therapy? Do we know if physiotherapy actually makes any difference to progress and, if so, how? Is the motor progress of children with Down syndrome just delayed (i.e. slower but otherwise the same as in other children) or is it actually different – due to physical differences in their muscles, ligaments or central nervous systems? Whatever the answers to these questions may be, we know from our own practical experience and research that the majority of children with Down syndrome achieve all the basic motor skills necessary for everyday living and personal independence. They may be later to achieve them, and their movements may seem a little clumsy or less refi ned as they carry out tasks, but they still have adequate skills for daily competence. They may have more diffi culty in becoming skilled in games and recreational activities but many individuals do reach high levels of achievement when given the opportunity. Research into the motor development and motor skills of children and adults with Down syndrome is limited and, as we have studied the available information, we have come to believe that some unhelpful myths keep being repeated as explanations, without supporting evidence. One of those myths is hypotonia or ‘poor muscle tone’. Almost every article we have read has used hypotonia as an explanation, when in fact it probably plays little part in determining children’s motor progress. We will return to this issue later. In this article, we consider four questions. 1. What do we know about motor development in typically developing children and the factors that may infl uence rates of progress or levels of skills achieved for different motor activities? 2. What do we know about the pattern of motor development usually seen in infants, children and teenagers with Down syndrome? 3. What do we know about the effects of therapeutic interventions? 4. Can we draw on these three sources of evidence to identify some principles for effective intervention and activity programmes for individuals with Down syndrome across the age range? Before we can discuss motor skills, What do we know about the movement abilities of children with Down syndrome?
Dynamics of cell‐mediated immune responses to cytomegalovirus in pediatric transplantation recipients

Patel M, Stefanidou M, Long CB, Fazzari MJ, Tesfa L, Del Rio M, Lamour J, Ricafort R, Madan RP, Herold BC. Dynamics of cell‐mediated immune responses to cytomegalovirus in pediatric transplantation recipients. Pediatr Transplantation 2012: 16: 18–28. © 2011 John Wiley & Sons A/S.
Analysis of PCC-OFDM systems for general time-varying channel

In this letter, we derive the general expression of ICI power for 1/2 rate PCC-OFDM system in terms of the correlation function of the channel. We have also developed the upper and lower bound of 1/2 rate PCC OFDM system and found that the ICI power reduction due to coding is about 11.9 dB. To examine the validity of the general expressions, we consider the example of carrier frequency offset (CFO), 2-path, Jakes' and uniform Doppler spread channel models and show that the results are consistent with simulations.
Building 3D Torus Using Low-Profile Expansion Cards

Torus is a subclass of direct topologies that was defined in theory to support \mbi n dimensions. Although recently some supercomputers have been built on a network with five and six dimensions, the most common case is when only three dimensions are implemented. In the market, there are low-profile communication expansion cards that have a reduced number of ports which is not enough to build tori of a certain number of dimensions. In this paper, we will deal with four-port expansion cards. By means of one of these cards per node, a 2-D torus topology could be built, but not a 3-D torus topology. However, two of these cards could be used to build each node of a 3-D torus topology. In this case, two ports are used to interconnect both cards each other, and the other six ports to connect to six neighbor nodes in the 3-D torus. Theoretically, there are several ways of assigning the dimension and direction of the ports. This paper presents a detailed study of the possible port configurations, and under specific network conditions, the best of them is obtained.
Fatty acid desaturase 1 gene polymorphisms control human hepatic lipid composition

Fatty acid desaturase (FADS) genes and their variants have been associated with multiple metabolic phenotypes, including liver enzymes and hepatic fat accumulation, but the detailed mechanism remains unclear. We aimed to delineate the role of FADSs in modulating lipid composition in human liver. We performed a targeted lipidomic analysis of a variety of phospholipids, sphingolipids, and ceramides among 154 human liver tissue samples. The associations between previously genome‐wide association studies (GWASs)‐identified six FADS single‐nucleotide polymorphisms (SNPs), and these lipid levels as well as total hepatic fat content (HFC) were tested. The potential function of these SNPs in regulating transcription of three FADS genes (FADS1, FADS2, and FADS3) in the locus was also investigated. We found that though these SNPs were in high linkage disequilibrium (r2 > 0.8), the rare alleles of these SNPs were consistently and significantly associated with the accumulation of multiple long‐chain fatty acids (LCFAs), with C47H85O13P (C36:4), a phosphatidylinositol (PI), and C43H80O8PN (C38:3), a phosphatidylethanolamine (PE), reached the Bonferroni corrected significance (P < 3 × 10−4). Meanwhile, these SNPs were significantly associated with increased ratios between the more saturated and relatively less saturated forms of LCFAs, especially between PEs, PIs, and phosphatidylcholines (PCs; P ≤ 3.5 × 10−6). These alleles were also associated with increased total HFC (P < 0.05). Further analyses revealed that these alleles were associated with decreased hepatic expression of FADS1 (P = 0.0018 for rs174556), but not FADS2 or FADS3 (P > 0.05). Conclusion: Our findings revealed critical insight into the mechanism underlying FADS1 and its polymorphisms in modulating hepatic lipid deposition by altering gene transcription and controlling lipid composition in human livers. (Hepatology 2015;61:119–128)
Proactive recovery for BTI in high-k SRAM cells

Recent studies of BTI behavior in SRAM cells showed that for high-K metal gate stack technology, PBTI induced Vth shift in NMOS is as significant as NBTI induced Vth shift in PMOS. Previous techniques of mitigating NBTI in SRAM focus mainly on PMOS and thus lack the ability to mitigate PBTI of NMOS transistors. In this paper, we propose a novel design to recover 4 internal gates within a SRAM cell simultaneously to mitigate both NBTI and PBTI effects. In the evaluated L2 cache, our technique effectively slows down the cell failure probability increase, and achieves 4.64/2.86× (best/worst case) lifetime improvement over normal design.
Using spam farm to boost PageRank

Nowadays web spamming has emerged to take the economic advantage of high search rankings and threatened the accuracy and fairness of those rankings. Understanding spamming techniques is essential for evaluating the strength and weakness of a ranking algorithm, and for fighting against web spamming. In this paper, we identify the optimal spam farm structure under some realistic assumptions in the single target spam farm model. Our result extends the optimal spam farm claimed by Gyöngyi and Garcia-Molina through dropping the assumption that leakage is constant. We also characterize the optimal spam farms under additional constraints, which the spammer may deploy to disguise the spam farm by deviating from the unconstrained optimal structure.
Partial flag varieties and preprojective algebras

Soit A une algebre preprojective de type A, D, E, et soit G le groupe algebrique complexe semi-simple et simplement connexe correspondant. Nous etudions les modules rigides des sous-categories Sub Q ou Q designe un Λ-inodule injectif, et nous introduisons une operation de mutation sur les modules rigides complets de Sub Q. Ceci conduit a des structures d'algebre amassee sur les anneaux de coordonnees des varietes de drapeaux partiels associees a G.
Using Texts in Science Education: Cognitive Processes and Knowledge Representation

Texts form a powerful tool in teaching concepts and principles in science. How do readers extract information from a text, and what are the limitations in this process? Central to comprehension of and learning from a text is the construction of a coherent mental representation that integrates the textual information and relevant background knowledge. This representation engenders learning if it expands the reader’s existing knowledge base or if it corrects misconceptions in this knowledge base. The Landscape Model captures the reading process and the influences of reader characteristics (such as working-memory capacity, reading goal, prior knowledge, and inferential skills) and text characteristics (such as content/structure of presented information, processing demands, and textual cues). The model suggests factors that can optimize—or jeopardize—learning science from text.
The dynamical evolution of fractal star clusters: the survival of substructure

We simulate the dynamics of fractal star clusters, in order to investigate the evolution of substructure in recently formed clusters. The velocity dispersion is found to be the key parameter determining the survival of substructure. In clusters with a low initial velocity dispersion, the ensuing collapse of the cluster tends to erase substructure, although some substructure may persist beyond the collapse phase. In clusters with virial ratios of 0.5 or higher, initial density substructure survives for several crossing times, in virtually all cases. Even an initially homogeneous cluster can develop substructure, if it is born with coherent velocity dispersion.Theseresults suggest that the simple initial conditions used for many sophisticated N -body simulations could be missing a very important and dramatic phase of star cluster evolution.
Meckel-Gruber syndrome and the role of primary cilia in kidney, skeleton, and central nervous system development

The ciliopathies are a group of related inherited diseases characterized by malformations in organ development. The diseases affect multiple organ systems, with kidney, skeleton, and brain malformations frequently observed. Research over the last decade has revealed that these diseases are due to defects in primary cilia, essential sensory organelles found on most cells in the human body. Here we discuss the genetic and cell biological basis of one of the most severe ciliopathies, Meckel-Gruber syndrome, and explain how primary cilia contribute to the development of the affected organ systems.