Miracle-dz/UniFAR-FTUs huggingface dataset:
Male adolescent concubinage in Peshawar, Northwestern Pakistan

This paper reports on findings from four interviews held with young men who have experienced male adolescent concubinage relationships with adult men in Peshawar, Northwestern Pakistan. These relationships are referred to by the Pashtun people involved as bacha baazi. Similar relationships (called bacabozlik) were described by Ingeborg Baldauf among the Uzbeks and Pashtun of Afghanistan, based on observations made in the late-1970s. This paper compares Baldauf's observations with our own, indicating significant differences and similarities. Implications for future research and for social protection programmes are discussed.
In vitro comparison of three techniques for ventriculo-aortic junction annuloplasty.

OBJECTIVES In aortic valve repair, reduction and stabilization of the ventriculo-aortic junction (VAJ) is generally recommended. In this in vitro study, we compare three techniques of annuloplasty: the subcommissural annuloplasty (SCA), the internal ring (IR) and the external ring (ER) annuloplasty. METHODS Ten fresh porcine aortic valve preparations were tested in a pulsatile mock loop. Each sample was tested untreated (baseline: B). The annuloplasty techniques were then performed successively in each sample. Each technique was tested, then removed and the following technique performed. SCA was applied at 50% of interleaflet triangle height; the ER and IR were applied with a moderate reduction (15-20%) of the VAJ. Hydrodynamic, video and echographic parameters were collected. Flow rate and arterial pressure were maintained consistently between groups. RESULTS Effective orifice area decreased significantly with each annuloplasty technique compared with baseline (P < 0.001). Mean transvalvular pressure drop was significantly higher in the ER and IR vs SCA (P = 0.007). Annuloplasty reduced valve opening and closing time in comparison to baseline. Echocardiography confirmed that the VAJ experienced a greater reduction with the ER and IR vs SCA. A narrowing of the lower third of the sinuses of Valsalva was observed after the ER, and subvalvular narrowing was observed after the IR. Valve coaptation increased with all annuloplasty techniques. CONCLUSIONS The three annuloplasty techniques examined demonstrated differential effects on aortic valve function and root morphology. The ER and IR have greater potential to reduce VAJ diameter in comparison to SCA. The IR induced a subvalvular remodelling of the VAJ, whereas the ER induced a paravalvular remodelling.
Protective effect of galangin in Concanavalin A-induced hepatitis in mice

Galangin is an active pharmacological ingredient from propolis and Alpinia officinarum Hance, and has been reported to have anti-inflammatory and antioxidative properties. The present study aims to reveal the effect of galangin on Concanavalin A (ConA)-induced hepatitis (CIH), a well-established animal model of immune-mediated liver injury, and to clarify the related mechanism. C57BL/6 mice were pretreated with galangin followed by ConA challenge. Results indicated that galangin inhibited ConA-induced liver damage. Mice pretreated with galangin showed more reduction of liver damage when compared with control mice pretreated with vehicle solution. In galangin-pretreated mice with induced CIH, increases in serum levels of several inflammatory cytokines, including tumor necrosis factor-α, interferon-γ, and interleukin-12 were dramatically attenuated, and chemokines and adhesion molecules like interferon inducible protein-10, macrophage inflammatory protein-1α, and inter-cellular adhesion molecule-1 messenger RNA expressions in liver were decreased. Moreover, CIH mice pretreated with galangin showed less leukocyte infiltration and T-cell activation in the liver. Further, the mechanism of the anti-inflammatory effects of galangin may be attributed to its modulation of crucial inflammatory signaling pathways, including nuclear factor kappa B and interferon-gamma/signal transducer and activator of transcription 1. Collectively, these findings suggest the preventive and therapeutic potential of galangin in immune-mediated liver injury in vivo.
A Histological Study of Aspergillus flavus Colonization of Wound Inoculated Maize Kernels of Resistant and Susceptible Maize Hybrids in the Field

Aspergillus flavus colonization in developing kernels of maize single-cross hybrids resistant (Mp313E × Mp717) and susceptible (GA209 × T173) to aflatoxin accumulation was determined in the field over three growing seasons (2012–2014). Plants were hand pollinated, and individual kernels were inoculated with a needle dipped in a suspension of A. flavus conidia 21 days after pollination. Kernels were harvested at 1- to 2-day intervals from 1 to 21 days after inoculation (DAI). Kernels were placed in FAA fixative, dehydrated, embedded in paraffin, sectioned, and stained with toluidine blue. Kernels were also collected additional kernels for aflatoxin analyses in 2013 and 2014. At 2 DAI, A. flavus hyphae were observed among endosperm cells in the susceptible hybrid, but colonization of the endosperm in the resistant hybrid was limited to the wound site of the resistant hybrid. Sections of the scutellum of the susceptible hybrid were colonized by A. flavus by 5 DAI. Fungal growth was slower in the resistant hybrid compared to the susceptible hybrid. By 10 DAI, A. flavus had colonized a large section of the embryo in the susceptible hybrid; whereas in the resistant hybrid, approximately half of the endosperm had been colonized and very few cells in the embryo were colonized. Fungal colonization in some of the kernels of the resistant hybrid was slowed in the aleurone layer or at the endosperm-scutellum interface. In wounded kernels with intact aleurone layers, the fungus spread around the kernel between the pericarp and aleurone layer with minimal colonization of the endosperm. Aflatoxin B1 was first detected in susceptible kernel tissues 8 DAI in 2013 (14 μg/kg) and 2014 (18 μg/kg). The resistant hybrid had significantly lower levels of aflatoxin accumulation compared to the susceptible hybrid at harvests 10, 21, and 28 DAI in 2013, and 20 and 24 DAI in 2014. Our study found differential A. flavus colonization of susceptible and resistant kernel tissues, and that the aleurone and the outer layer of the scutellum slowed the rate of colonization by A. flavus.
Causal Mediation Analysis With Survival Data

Causal mediation analysis is considered for time-to-event outcomes and survival analysis models. Different possible effect decompositions are discussed for the survival function, hazard, mean survival time and median survival scales. Approaches to mediation analysis in the social sciences are related to counterfactual approaches using additive hazard, proportional hazard and accelerated failure time models. The product-coefficient method from the social sciences gives mediated effects on the hazard difference scale for additive hazard models, on the log mean survival time difference scale for accelerated failure time models, and on the log hazard scale for the proportional hazards model but only if the outcome is rare. With the proportional hazards model and a common outcome, the product-coefficient method can provide a valid test for the presence of a mediator effect but does not provide a measure. When additive hazard, accelerated failure time, or the rare-outcome proportional hazards models are employed and combined with the counterfactual approach, exposure-mediator interactions can be accommodated in a relatively straightforward manner.
Hydrolates and Gellan: An Eco-innovative Synergy for Safe Cleaning of Paper Artworks

ABSTRACT The gellan hydrogel is used as a cleaning agent for paper artworks. The purposes of this work were to give the gellan hydrogel both a microbial resistance and a cytocidal action against the biodeteriogens using hydrolates. Broth microdilution assays were performed to identify the fungicidal action of 16 hydrolates vs 3 fungal strains. The study concerned the Minimal Fungicidal Concentration and pH, colour, and ultra-structural variations on all paper samples, by placing them in contact with GELYD (GELlan + hYDrolat). The in vitro tests showed that eight out of 16 hydrolates strongly inhibited fungal growth, but only two of them (Monarda fistulosa, Citrus aurantium subsp amara) showed in situ fungicidal action. Data indicate a new and interesting eco-innovative use of hydrolates, since GELYD is able not only to clean paper artworks, but also to kill the fungal cells present on paper that are potentially harmful for paper and operators.
Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females

Background In recent years, a relationship between Helicobacter pylori and many disease conditions has been reported, however, studies in its relationship with multiple sclerosis (MS) have had contradictory results. Objective To determine the association between the H. pylori infection and MS. Methods 550 patients with MS were included in the study and were matched by gender and year of birth to 299 controls. Patients were assessed for clinical and demographic parameters. An enzyme immunoassay was used to detect the presence of specific IgG antibodies against H. pylori in the serum sample of both groups. Results H. pylori seropositivity was found to be lower in the patients with MS than in controls (16% vs 21%) with the decrease pertaining to females (14% vs 22%, p=0.027) but not males (19% vs 20%, p=1.0). When adjusted for age at onset, year of birth and disease duration, H. pylori seropositive females presented with a lower disability score than seronegative females (p=0.049), while among males the reverse was true (p=0.025). There was no significant association between H. pylori seropositivity and relapse rate. Conclusions Our results could reflect a protective role of H. pylori in the disease development. However, it may be that H. pylori infection is a surrogate marker for the ‘hygiene hypothesis’, a theory which postulates that early life infections are essential to prime the immune system and thus prevent allergic and autoimmune conditions later in life. The fact that the association between H. pylori seropositivity and MS risk was seen almost exclusively in females requires further investigation.
Applied Sketching in HCI: Hands-on Course of Sketching Techniques

Hand-drawn sketches are an easy way for researchers to communicate and express ideas, as well as document, explore and describe concepts between researcher, user, or client. Sketches are fast, easy to create, and -- by varying their fidelity -- they can be used in all areas of HCI. The Applied Sketching in HCI course will explore and demonstrate themes around sketching in HCI with the aim of producing tangible outputs. Those attending will leave the course with the confidence to engage actively with sketching on a day-to-day basis. Participants will be encouraged to apply what they have learned to their own research.
Spatial characteristics of calcium signalling : the calcium wave as a basic unit in plant cell calcium signalling

Many signals that modify plant cell growth and development initiate changes in cytoplasmic Ca2+. The subsequent movement of Ca2+ in the cytoplasm is thought to take place via waves of free Ca2+. These waves may be initiated at de¢ned regions of the cell and movement requires release from a reticulated endoplasmic reticulum and the vacuole. The mechanism of wave propagation is outlined, and the possible basis of repetitive wave formation, Ca2+ oscillations and capacitative Ca2+ signalling is discussed. Evidence for the presence of Ca2+ waves in plant cells is outlined, and from studies on raphides it is suggested that the capabilities for capacitative Ca2+ signalling are also present. The paper ¢nishes with an outline of the possible interrelation between Ca2+ waves and organelles and describes the intercellular movement of Ca2+ waves and the relevance of such information communication to plant development.
Advanced platelet‐rich fibrin and freeze‐dried bone allograft for ridge preservation: A randomized controlled clinical trial

BACKGROUND Advanced platelet-rich fibrin (A-PRF) is an autogenous blood product with applications in dento-alveolar surgery. However, there is minimal information regarding its optimal clinical application or efficacy. The aim of this multi-arm parallel randomized controlled clinical trial was to evaluate the efficacy of A-PRF alone or with freeze-dried bone allograft (FDBA) in improving vital bone formation and alveolar dimensional stability during ridge preservation. METHODS Forty patients requiring extraction of non-molar teeth and replacement with dental implants were randomized into one of four ridge preservation approaches: A-PRF, A-PRF+FDBA, FDBA, or blood clot. A-PRF was prepared at 1,300 rpm for 8 minutes. Non-traumatic extractions and ridge preservation was performed. After an average of 15 weeks healing, bone core samples were harvested at the time of implant placement for micro-CT and histomorphometric analysis. Ridge dimensions were measured immediately after extraction and before implant placement. RESULTS Significantly greater loss of ridge height was noted in the blood clot group (3.8 ± 2.0 mm) compared to A-PRF (1.8 ± 2.1 mm) and A-PRF+FDBA (1.0 ± 2.3 mm) groups (P < 0.05). No significant differences in ridge width reduction were noted between groups. Significantly more vital bone was present in the A-PRF group (46% ± 18%) compared to the FDBA group (29% ± 14%) (P < 0.05). Bone mineral density was significantly greater in the FDBA group (551 ± 58 mg/cm3 ) compared to blood clot (487 ± 64 mg/cm3 ) (P < 0.05). CONCLUSIONS This study demonstrates A-PRF alone or augmented with FDBA is a suitable biomaterial for ridge preservation. This study represents the first randomized controlled clinical trial comparing A-PRF with and without FDBA to FDBA alone for ridge preservation.
Anti-Psoriatic Drug Monomethylfumarate Increases Nuclear Factor Erythroid 2-Related Factor 2 Levels and Induces Aquaporin-3 mRNA and Protein Expression

Oxidative stress contributes to inflammatory skin diseases, including psoriasis. Monomethylfumarate (MMF) is an antipsoriatic agent with a poorly understood mechanism of action. In other cell types MMF increases the expression of nuclear factor erythroid-derived 2-like 2 (Nrf2), a transcription factor that regulates cellular antioxidant responses, to reduce oxidative stress like that observed in inflammatory disorders such as multiple sclerosis. We tested the hypothesis that MMF enhances Nrf2 activity in keratinocytes, thereby improving their capacity to counteract environmental stresses. We used Western analysis, immunofluorescence, and real-time quantitative reverse-transcription polymerase chain reaction to examine the effect of MMF on the expression of Nrf2 and its targets. We also measured intracellular reactive oxygen species (ROS) levels following MMF treatment. Our data show that MMF increased total and nuclear Nrf2 levels in primary mouse keratinocytes and enhanced mRNA expression of several Nrf2-downstream effectors, including heme oxygenase-1 and peroxiredoxin-6. Moreover, MMF treatment attenuated the generation of ROS following hydrogen peroxide treatment. On the other hand, the expression and membranous localization of aquaporin-3 (AQP3), a glycerol channel implicated in keratinocyte differentiation, was stimulated by MMF, which also enhanced keratinocyte glycerol uptake. The Nrf2 activator sulforaphane also increased AQP3 levels, suggesting that AQP3 expression may be regulated by Nrf2. We show for the first time that MMF stimulates Nrf2 and AQP3 expression and function/activity in keratinocytes. This effect may account, in part, for the previously observed ability of MMF to inhibit proliferation and inflammatory mediator production and promote differentiation in keratinocytes and to treat psoriasis.
Performance of an Automatic Ball Balancer with dry Friction

In many industrial applications imbalance is a major cause for unwanted vibrations. One way to compensate for an unknown imbalance is the implementation of an automatic ball balancer. Oil-lubricated automatic ball balancers are applied in hand-held tools and washers. However, in applications such as optical drives fluid lubrication is highly undesirable since it may destroy the optical system upon leakage. Therefore, in this paper, the balancing performance of an automatic ball balancer without fluid lubrication is investigated. The absence of fluid lubrication gives rise to dry friction phenomena which cause the existence of equilibrium sets of the balls in the automatic ball balancer. A model of the system with dry friction, modeled by a set-valued force law, is built based on dedicated experiments. The resulting equilibrium sets and their dependency on system parameters are studied and the consequences for the balancing performance is assessed. Based on these results, it can be concluded that in parts of such equilibrium sets the balancing performance deteriorates when compared to the system without automatic ball balancer; in other words, the balancing performance is endangered by the presence of dry friction. This conclusion is supported by both numerical and experimental results.
Chip-Based Brillouin Processing for Phase Control of RF Signals

Manipulating radio frequency (RF) signals in integrated photonic devices has recently emerged as a new paradigm for wireless communications, enabling high-frequency signal processing and broadband frequency agility in miniaturized photonic platforms. These advances are crucial for space and airborne applications which are weight and size sensitive. Recent progress in on-chip stimulated Brillouin scattering (SBS) using high gain has shown great potentials for RF photonic signal processing, owing to its inherent advantages of high resolution, high reconfigurability, and flexible programmability. On-chip SBS serves as a versatile and high-performance toolbox to process and manipulate the amplitude and phase of RF signals in the optical domain. In this paper, we provide a brief overview of recent advances achieved using SBS in planar waveguides, with a focus on applications requiring phase control of RF signals, including phase shifters, delay lines, and separate carrier tuning. We introduce a power-efficient scheme based on the concept of phase amplification to improve Brillouin-based phase processing capability.
What is the Best Spatial Distribution to Model Base Station Density? A Deep Dive into Two European Mobile Networks

This paper studies the base station (BS) spatial distributions across different scenarios in urban, rural, and coastal zones, based on real BS deployment data sets obtained from two European countries (i.e., Italy and Croatia). Basically, this paper takes into account different representative statistical distributions to characterize the probability density function of the BS spatial density, including Poisson, generalized Pareto, Weibull, lognormal, and α-Stable. Based on a thorough comparison with real data sets, our results clearly assess that the α-Stable distribution is the most accurate one among the other candidates in urban scenarios. This finding is confirmed across different sample area sizes, operators, and cellular technologies (GSM/UMTS/LTE). On the other hand, the lognormal and Weibull distributions tend to fit better the real ones in rural and coastal scenarios. We believe that the results of this paper can be exploited to derive fruitful guidelines for BS deployment in a cellular network design, providing various network performance metrics, such as coverage probability, transmission success probability, throughput, and delay.
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium

Objective: Previous nomogram models for patients undergoing resection of intraductal papillary mucinous neoplasms (IPMNs) have been relatively small single-institutional series. Our objective was to improve upon these studies by developing and independently validating a new model using a large multiinstitutional dataset. Summary Background Data: IPMNs represent the most common radiographically identifiable precursor lesions of pancreatic cancer. They are a heterogenous group of neoplasms in which more accurate markers of high-grade dysplasia or early invasive carcinoma could help avoid unnecessary surgery in 1 case and support potentially curative intervention (resection) in another. Methods: Prospectively maintained databases from 3 institutions were queried for patients who had undergone resection of IPMNs between 2005 and 2015. Patients were separated into main duct [main and mixed-type (MD)] and branch duct (BD) types based on preoperative imaging. Logistic regression modeling was used on a training subset to develop 2 independent nomograms (MD and BD) to predict low-risk (low- or intermediate-grade dysplasia) or high-risk (high-grade dysplasia or invasive carcinoma) disease. Model performance was then evaluated using an independent validation set. Results: We identified 1028 patients who underwent resection for IPMNs [MD: n = 454 (44%), BD: n = 574 (56%)] during the 10-year study period. High-risk disease was present in 487 patients (47%). Patients with high-risk disease comprised 71% and 29% of MD and BD groups, respectively (P <0.0001). MD and BD nomograms were developed on the training set [70% of total (n = 720); MD: n = 318, BD: n = 402] and validated on the test set [30% (n = 308); MD: n = 136, BD: n = 172]. The presence of jaundice was almost exclusively associated with high-risk disease (57 of 58 patients, 98%). Cyst size >3.0 cm, solid component/mural nodule, pain symptoms, and weight loss were significantly associated with high-risk disease. C-indices were 0.82 and 0.81 on training and independent validation sets, respectively; Brier scores were 0.173 and 0.175, respectively. Conclusions: For patients with suspected IPMNs, we present an independently validated model for the prediction of high-risk disease.
Multi-Head Decoder for End-to-End Speech Recognition

This paper presents a new network architecture called multi-head decoder for end-to-end speech recognition as an extension of a multi-head attention model. In the multi-head attention model, multiple attentions are calculated, and then, they are integrated into a single attention. On the other hand, instead of the integration in the attention level, our proposed method uses multiple decoders for each attention and integrates their outputs to generate a final output. Furthermore, in order to make each head to capture the different modalities, different attention functions are used for each head, leading to the improvement of the recognition performance with an ensemble effect. To evaluate the effectiveness of our proposed method, we conduct an experimental evaluation using Corpus of Spontaneous Japanese. Experimental results demonstrate that our proposed method outperforms the conventional methods such as location-based and multi-head attention models, and that it can capture different speech/linguistic contexts within the attention-based encoder-decoder framework.