Miracle-dz/UniFAR-FTUs huggingface dataset:
Describing team development within a novel GP-led urgent care centre model: a qualitative study

Objective Urgent care centres (UCCs) co-located within an emergency department were developed to reduce the numbers of inappropriate emergency department admissions. Since then various UCC models have developed, including a novel general practitioner (GP)-led UCC that incorporates both GPs and emergency nurse practitioners (ENPs). Traditionally these two groups do not work alongside each other within an emergency setting. Although good teamwork is crucial to better patient outcomes, there is little within the literature about the development of a team consisting of different healthcare professionals in a novel healthcare setting. Our aim was therefore to describe staff members' perspectives of team development within the GP-led UCC model. Design Open-ended semistructured interviews, analysed using thematic content analysis. Setting GP-led urgent care centres in two academic teaching hospitals in London. Participants 15 UCC staff members including six GPs, four ENPs, two receptionists and three managers. Results Overall participants were positive about the interprofessional team that had developed and recognised that this process had taken time. Hierarchy within the UCC setting has diminished with time, although some residual hierarchical beliefs do appear to remain. Staff appreciated interdisciplinary collaboration was likely to improve patient care. Eight key facilitating factors for the team were identified: appointment of leaders, perception of fair workload, education on roles/skill sets and development of these, shared professional understanding, interdisciplinary working, ED collaboration, clinical guidelines and social interactions. Conclusions A strong interprofessional team has evolved within the GP-led UCCs over time, breaking down traditional professional divides. Future implementation of UCC models should pro-actively incorporate the eight facilitating factors identified from the outset, to enable effective teams to develop more quickly.
Conté: multimodal input inspired by an artist's crayon

Conté is a small input device inspired by the way artists manipulate a real Conté crayon. By changing which corner, edge, end, or side is contacting the display, the operator can switch interaction modes using a single hand. Conté's rectangular prism shape enables both precise pen-like input and tangible handle interaction. Conté also has a natural compatibility with multi-touch input: it can be tucked in the palm to interleave same-hand touch input, or used to expand the vocabulary of bimanual touch. Inspired by informal interviews with artists, we catalogue Conté's characteristics, and use these to outline a design space. We describe a prototype device using common materials and simple electronics. With this device, we demonstrate interaction techniques in a test-bed drawing application. Finally, we discuss alternate hardware designs and future human factors research to study this new class of input.
A Low-Voltage Lateral SJ-FINFET With Deep-Trench p-Drift Region

A novel device structure that is suitable for practical implementation of lateral superjunction FINFET (SJ-FINFET) on a silicon-on-insulator platform is proposed for sub-200-V rating power applications. The SJ-FINFET structure with heavily doped alternating U-shaped n/p pillars is introduced to minimize both channel and drift resistances and to mitigate electron current crowding near the top of n-drift region. The proposed device structure exhibits low R on, sp with voltage ratings below 200 V. The optimal device characteristics were validated by a 3-D numerical device simulator, ISE-DESSIS. The simulations with trench depths of 2 and 3 mum were analyzed for several different drift lengths and found to be able to overcome the Si limit with the breakdown voltages of 165 and 90 V, respectively.
The Two Nucleotide-binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Have Distinct Functions in Controlling Channel Activity (*)

The cystic fibrosis transmembrane conductance regulator (CFTR) Cl channel contains two cytoplasmic nucleotide-binding domains (NBDs). After phosphorylation of the R domain, ATP interacts with the NBDs to regulate channel activity. To learn how the NBDs regulate channel function, we used the patch-clamp technique to study CFTR and variants which contained site-directed mutations in the conserved Walker A motif lysine residues in either NBD1 (K464A), NBD2 (K1250A and K1250M), or both NBDs simultaneously (K464A/K1250A). Studies in related proteins suggest that such mutations slow the rate of ATP hydrolysis. These mutations did not alter the conductive properties of the channel or the requirement for phosphorylation and ATP to open the channel. However, all mutations decreased open state probability. Mutations in NBD1 decreased the frequency of bursts of activity, whereas mutations in NBD2 and mutations in both NBDs simultaneously prolonged bursts of activity, as well as decreased the frequency of bursts. These results could not be attributed to altered binding of nucleotide because none of the mutants studied had reduced 8-N3ATP binding. These data suggest that the two NBDs have distinct functions in channel gating; ATP hydrolysis at NBD1 initiates a burst of activity, and hydrolysis at NBD2 terminates a burst.
DON'T FORGET THE BIOLOGY: A REPLY TO GREEN

In our 1998 paper (Eberhard et al. 1998), we tested several hypotheses regarding the possible selective factors involved in the evolution of animal genitalia. We compared the slopes of log-log ordinary least squares (OLS) regressions of genitalia on indicators of body size with the slopes of other body parts on the same indicators in 20 species of insects and spiders. Our major conclusions regarding the rejection of male-female conflict, good viability genes, and lock and key arguments (see Abstract) are unaffected by the reanalysis proposed by Green (1999), even if it were more appropriate than ours, which we doubt (see below). In neither our OLS regressions nor Green’s reduced major axis (RMA) regressions are the slopes of genitalia greater than those of other body parts, as would be expected if genitalia were used as weapons in forceful intraspecific battles (the male-female conflict hypothesis) or as signals of male size (good viability genes hypothesis). Instead, the slopes show a statistically significant trend to be lower in both analyses. In addition, neither we nor Green found differences on comparing the slopes of the genitalia of the species in which lock and key considerations might be important (species in which male genitalia fit against rigid female genitalic structures) with the slopes in species in which lock and key can be ruled out because of the mechanical mesh of the male’s genitalia with those of the female. So, conservatively, we conclude that the major conclusions of our paper are not affected under Green’s reanalysis. It is important not to lose sight of the biological questions being tested in debates over statistical methods. There are a number of reasons, however, to doubt several of Green’s points. Green’s claim that reanalysis is needed, the analysis he performed, and the additional explanations that he proposed in preference to those we mentioned in our original paper all have serious problems. We will discuss first the statistical questions, and then the more directly biological questions. Is RMA Regression More Appropriate?
Factors Affecting Perceived Stigma in Leprosy Affected Persons in Western Nepal

Background There are various factors which construct the perception of stigma in both leprosy affected persons and unaffected persons. The main purpose of this study was to determine the level of perceived stigma and the risk factors contributing to it among leprosy affected person attending the Green Pastures Hospital, Pokhara municipality of western Nepal. Methods A cross-sectional study was conducted among 135 people affected by leprosy at Green Pastures Hospital and Rehabilitation Centre. Persons above the age of 18 were interviewed using a set of questionnaire form and Explanatory Model Interview Catalogue (EMIC). In addition, two sets of focused group discussions each containing 10 participants from the ward were conducted with the objectives of answering the frequently affected EMIC items. Results Among 135 leprosy affected persons, the median score of perceived stigma was 10 while it ranged from 0–34. Higher perceived stigma score was found in illiterate persons (p = 0.008), participants whose incomes were self-described as inadequate (p = 0.014) and who had changed their occupation due to leprosy (p = 0.018). Patients who lacked information on leprosy (p = 0.025), knowledge about the causes (p = 0.02) and transmission of leprosy (p = 0.046) and those who had perception that leprosy is a severe disease (p<0.001) and is difficult to treat (p<0.001) had higher perceived stigma score. Participants with disfigurement or deformities (p = 0.014), ulcers (p = 0.022) and odorous ulcers (p = 0.043) had higher perceived stigma score. Conclusion The factors associated with higher stigma were illiteracy, perceived economical inadequacy, change of occupation due to leprosy, lack of knowledge about leprosy, perception of leprosy as a severe disease and difficult to treat. Similarly, visible deformities and ulcers were associated with higher stigma. There is an urgent need of stigma reduction strategies focused on health education and health awareness programs in addition to the necessary rehabilitation support.
Modeling the 802.11 Protocol Under Different Capture and Sensing Capabilities

Decentralized medium access control schemes for wireless networks based on CSMA/CA, such as the 802.11 protocol, are known to be unfair. In multi-hop networks, they can even favor some connections to such an extent that the others suffer from virtually complete starvation. This observation has been reported in quite a few works, but the factors causing it are still not well understood. We find that the capture effect and the relative values of the receiving and carrier sensing ranges play a crucial role in the unfairness of these protocols. We show that an idealized 802.11 protocol does suffer from starvation when the receiving and sensing ranges are equal, but quite surprisingly this unfairness is reduced or even disappears when these two ranges are sufficiently different. Using a Markovian model, we explain why apparently benign variations in these ranges have such a dramatic impact on the 802.11 protocol performance.
A 7.2 mW 75.3 dB SNDR 10 MHz BW CT Delta-Sigma Modulator Using Gm-C-Based Noise-Shaped Quantizer and Digital Integrator

This paper presents a continuous-time (CT) delta-sigma modulator using a Gm-C based noise-shaped integrating quantizer (NSIQ) with a digital back-end integrator. By incorporating the digital back-end integrator, the tradeoff between resolution and speed for a conventional time-based NSIQ is alleviated. Using only three clock edges and a low-power Gm-C, effective 4-bit quantization with an additional first order noise-shaping is achieved. Also, the linearity requirement of the quantizer is relaxed by employing the digital back-end integrator. The proposed modulator was fabricated in a 0.13 <inline-formula> <tex-math notation="LaTeX">$\mu \text {m}$ </tex-math></inline-formula> CMOS process with an active area of 0.08 <inline-formula> <tex-math notation="LaTeX">$\text {mm}^{2}$ </tex-math></inline-formula>. It operates at 640 MHz and achieves a peak SNDR of 75.3 dB and a peak SFDR of 94.1 dB in a 10 MHz bandwidth while consuming 7.2 mW from a 1.2 V power supply.
Theoretical problems in nonsymmetric gravitational theory.

It has recenty been noted that the nonsymmetric metric model of gravity faces severe observational constraints. We show here that it is also subject to physically unacceptable formal difficulties even as an effective field theory: When expanded about a Riemannian background, the model exhibits curvature-coupled negative-energy (ghost) modes and unacceptable asymptotic behavior.
Increased Drought Impacts on Temperate Rainforests from Southern South America: Results of a Process-Based, Dynamic Forest Model

Increased droughts due to regional shifts in temperature and rainfall regimes are likely to affect forests in temperate regions in the coming decades. To assess their consequences for forest dynamics, we need predictive tools that couple hydrologic processes, soil moisture dynamics and plant productivity. Here, we developed and tested a dynamic forest model that predicts the hydrologic balance of North Patagonian rainforests on Chiloé Island, in temperate South America (42°S). The model incorporates the dynamic linkages between changing rainfall regimes, soil moisture and individual tree growth. Declining rainfall, as predicted for the study area, should mean up to 50% less summer rain by year 2100. We analysed forest responses to increased drought using the model proposed focusing on changes in evapotranspiration, soil moisture and forest structure (above-ground biomass and basal area). We compared the responses of a young stand (YS, ca. 60 years-old) and an old-growth forest (OG, >500 years-old) in the same area. Based on detailed field measurements of water fluxes, the model provides a reliable account of the hydrologic balance of these evergreen, broad-leaved rainforests. We found higher evapotranspiration in OG than YS under current climate. Increasing drought predicted for this century can reduce evapotranspiration by 15% in the OG compared to current values. Drier climate will alter forest structure, leading to decreases in above ground biomass by 27% of the current value in OG. The model presented here can be used to assess the potential impacts of climate change on forest hydrology and other threats of global change on future forests such as fragmentation, introduction of exotic tree species, and changes in fire regimes. Our study expands the applicability of forest dynamics models in remote and hitherto overlooked regions of the world, such as southern temperate rainforests.
Semantic Segmentation of Small Objects and Modeling of Uncertainty in Urban Remote Sensing Images Using Deep Convolutional Neural Networks

We propose a deep Convolutional Neural Network (CNN) for land cover mapping in remote sensing images, with a focus on urban areas. In remote sensing, class imbalance represents often a problem for tasks like land cover mapping, as small objects get less prioritised in an effort to achieve the best overall accuracy. We propose a novel approach to achieve high overall accuracy, while still achieving good accuracy for small objects. Quantifying the uncertainty on a pixel scale is another challenge in remote sensing, especially when using CNNs. In this paper we use recent advances in measuring uncertainty for CNNs and evaluate their quality both qualitatively and quantitatively in a remote sensing context. We demonstrate our ideas on different deep architectures including patch-based and so-called pixel-to-pixel approaches, as well as their combination, by classifying each pixel in a set of aerial images covering Vaihingen, Germany. The results show that we obtain an overall classification accuracy of 87%. The corresponding F1- score for the small object class "car" is 80.6%, which is higher than state-of-the art for this dataset.
Antioxidative Properties of Vanillic Acid Esters in Multiple Antioxidant Assays

The antioxidative properties of vanillic acid esters were systematically evaluated by multiple assays to compare with the well-known antioxidants, vanillic acid and Trolox. We first performed assays with the model radicals, DPPH, galvinoxyl and ABTS cation (ABTS•+) types. Methyl vanillate, ethyl vanillate and butyl vanillate showed stronger activity than Trolox in the ABTS•+-scavenging assay, but showed no activity in the DPPH radical- and galvinoxyl radical-scavenging assays. In contrast, vanillic acid could quench the three radicals. We then evaluated their antioxidative activities by an ORAC assay and an oxidative hemolysis inhibition assay (OxHLIA), using physiologically relevant peroxyl radicals. Vanillic acid esters and vanillic acid exerted much stronger activity than Trolox in the ORAC assay and OxHLIA. The antioxidative activity by OxHLIA was strongly correlated to the lipophilicity of vanillic acid and its esters. These results indicate that the protective effect of vanillic acid esters against free radical-induced biomembrane damage increased with increasing lipophilicity.
The role of anti‐Müllerian hormone in female fertility and infertility – an overview

Anti‐Müllerian hormone (AMH) plasma levels reflect the continuous non‐cyclic growth of small follicles, thereby mirroring the size of the resting primordial follicle pool and thus acting as a useful marker of ovarian reserve. Anti‐Müllerian hormone seems to be the best endocrine marker for assessing the age‐related decline of the ovarian pool in healthy women; thus, it has a potential ability to predict future reproductive lifespan. The most established role for AMH measurements is before in vitro fertilization is initiated, because AMH can be predictive of the ovarian response, namely poor and hyper‐responses. However, recent research has also highlighted the use of AMH in a variety of ovarian pathological conditions, including polycystic ovary syndrome, granulosa cell tumors and premature ovarian failure. A new commercial enzyme‐linked immunosorbent assay for measuring AMH levels has been developed, making results from different studies more comparable. Nevertheless, widespread clinical application awaits an international standard for AMH, so that results using future assays can be reliably compared.
Health outcomes following treatment for 6 months with once daily tiotropium compared with twice daily salmeterol in patients with COPD

We wish to clarify issues raised by your recent letter regarding the abovementioned paper published in May 2003 in Thorax (2003; 58 :399–404). Our intention was to notify the editors and to reference the paper by Donohue et al appearing in Chest . We believe this is evidenced by our declaring in the cover letter that the data from one of the two trials were under review. However, we wish to apologise that we did not follow this up and did …
PROPERTIES OF THE YOUNGEST PROTOSTARS IN PERSEUS, SERPENS, AND OPHIUCHUS

We present an unbiased census of deeply embedded protostars in Perseus, Serpens, and Ophiuchus, assembled by combining large-scale 1.1 mm Bolocam continuum and Spitzer Legacy surveys. We identify protostellar candidates based on their mid-infrared (mid-IR) properties, correlate their positions with 1.1 mm core positions from Enoch et al. in and , and Young et al. in , and construct well-sampled spectral energy distributions using our extensive wavelength coverage (λ = 1.25–1100 μm). Source classification based on the bolometric temperature yields a total of 39 Class 0 and 89 Class I sources in the three-cloud sample. We compare to protostellar evolutionary models using the bolometric temperature–luminosity diagram, finding a population of low-luminosity Class I sources that are inconsistent with constant or monotonically decreasing mass accretion rates. This result argues strongly for episodic accretion during the Class I phase, with more than 50% of sources in a “sub-Shu” (dM/dt < 10−6M☉ yr−1) accretion state. Average spectra are compared to protostellar radiative transfer models, which match the observed spectra fairly well in Stage 0, but predict too much near-IR and too little mid-IR flux in Stage I. Finally, the relative number of Class 0 and Class I sources is used to estimate the lifetime of the Class 0 phase; the three-cloud average yields a Class 0 lifetime of 1.7 ± 0.3 × 105 yr, ruling out an extremely rapid early accretion phase. Correcting photometry for extinction results in a somewhat shorter lifetime (1.1 × 105 yr). In Ophiuchus, however, we find very few Class 0 sources (NClass 0/NClass I ∼ 0.1–0.2), similar to previous studies of that cloud. The observations suggest a consistent picture of nearly constant average accretion rate through the entire embedded phase, with accretion becoming episodic by at least the Class I stage, and possibly earlier.
Randomized placebo-controlled trial of isotretinoin in chemoprevention of bronchial squamous metaplasia.

PURPOSE Retinoids have proven chemopreventive efficacy in both preclinical and clinical studies. This trial was designed to confirm the finding of an earlier uncontrolled trial that the synthetic retinoid etretinate had major activity in reversing squamous metaplasia found in the bronchial epithelium of chronic smokers. PATIENTS AND METHODS We prospectively evaluated 152 smokers with bronchoscopy and obtained biopsies from six sites. Subjects with dysplasia and/or a metaplasia index of greater than 15% were randomly assigned to receive either 1 mg/kg isotretinoin or placebo daily for 6 months. Of 86 subjects randomized (41 isotretinoin, 45 placebo), 69 were reevaluated at the completion of treatment. RESULTS In the group as a whole, the metaplasia index decreased over time from a mean +/- SE of 35.8% +/- 2.7% at baseline to 28.1% +/- 3.3% at the completion of treatment (P = .01) by repeated measures analysis of variance [ANOVA]); a reduction in the metaplasia index (> 8%) was noted in both isotretinoin and placebo groups (19 of 35 [54.3%] and 20 of 34 [58.8%], respectively). Complete reversal of squamous metaplasia was noted in nine subjects from each group. However, the magnitudes of the mean metaplasia index changes did not differ significantly in the two treatment groups. In both groups, smoking cessation resulted in significant declines in the extent of squamous metaplasia, whereas no significant change in metaplasia index was found among those who continued to smoke. CONCLUSION Squamous metaplasia was frequently observed in bronchial biopsy samples from chronic smokers. From this study, we conclude that isotretinoin has no effect on squamous metaplasia, a potential intermediate end point of bronchial carcinogenesis. Although determining the exact role of isotretinoin in lung cancer prevention requires further study, the finding that there was a significant decrease in squamous metaplasia in the placebo group emphasizes the critical importance of a placebo-controlled study design in chemoprevention trials using intermediate end points.
Role of the Apolipoprotein E Polymorphisms in the Development of Retinal Vein Occlusion in a Tunisian Population: A Case–Control Study

Apolipoprotein E (APOE) is a member of the apolipoprotein gene family. APOE is polymorphic with 3 main allelic types: ∊2, ∊3, and ∊4. Certain of these alleles have been associated with higher vascular risk. However, the association of APOE genotypes with retinal biomarkers and risk of retinal stroke is less clear. This study evaluated the role of APOE polymorphisms in retinal vein occlusion (RVO). In the present study, 2-point mutations coding amino acid residues 112 and 158 were amplified using the polymerase chain reaction (PCR) from DNA extracted from Tunisian participants. APOE genotypes were determined by multiplex PCR followed by molecular hybridization. Eighty-eight patients (26 women and 62 men) and 100 age- and gender-matched healthy participants were enrolled. The statistical study revealed a higher frequency of the ∊4 allele in patients as compared to controls (27.3% vs 9%) with a significant association of the ∊4 allele with the disease (P < 10−3, Pa < 10−3, odds ratio [OR] = 3.8, 95% confidence interval [CI] = 2.1-6.8). The frequency of the ∊3 allele was significantly lower in the patients with RVO compared to the controls (60.2% vs 82.5%, respectively; P < 10−3, Pa < 10−3, OR = 0.32, 95% CI = 0.19-0.53). The ∊3 allele seems to be protective against the disease. There was no association between the APO ∊2 allele and RVO. The association of APOE allele and genotype with RVO requires further investigation in different populations.