Miracle-dz/UniFAR-FTUs huggingface dataset:
Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines.

AIM Association mapping with lymphoblastoid cell lines (LCLs) is a promising approach in pharmacogenomics research, and in the current study we utilized LCLs to perform association mapping for 29 chemotherapy drugs. MATERIALS & METHODS Currently, we use LCLs to perform genome-wide association mapping of the cytotoxic response of 520 European-Americans to 29 different anticancer drugs; the largest LCL study to date. A novel association approach using a multivariate analysis of covariance design was employed with the software program MAGWAS, testing for differences in the dose-response profiles between genotypes without making assumptions about the response curve or the biologic mode of association. Additionally, by classifying 25 of the 29 drugs into eight families according to structural and mechanistic relationships, MAGWAS was used to test for associations that were shared across each drug family. Finally, a unique algorithm using multivariate responses and multiple linear regressions across pairs of response curves was used for unsupervised clustering of drugs. RESULTS Among the single-drug studies, suggestive associations were obtained for 18 loci, 12 within/near genes. Three of these, MED12L, CHN2 and MGMT, have been previously implicated in cancer pharmacogenomics. The drug family associations resulted in four additional suggestive loci (three contained within/near genes). One of these genes, HDAC4, associated with the DNA alkylating agents, shows possible clinical interactions with temozolomide. For the drug clustering analysis, 18 of 25 drugs clustered into the appropriate family. CONCLUSION This study demonstrates the utility of LCLs in identifying genes that have clinical importance in drug response and for assigning unclassified agents to specific drug families, and proposes new candidate genes for follow-up in a large number of chemotherapy drugs.
Evaluating the Impact of Coder Errors on Active Learning

Active Learning (AL) has been proposed as a technique to reduce the amount of annotated data needed in the context of supervised classification. While various simulation studies for a number of NLP tasks have shown that AL works well on goldstandard data, there is some doubt whether the approach can be successful when applied to noisy, real-world data sets. This paper presents a thorough evaluation of the impact of annotation noise on AL and shows that systematic noise resulting from biased coder decisions can seriously harm the AL process. We present a method to filter out inconsistent annotations during AL and show that this makes AL far more robust when applied to noisy data.
Resistance and Compliance in Immigrant–Native Figurations: Albanian and Soviet Greek Immigrants and Their Interaction with Greek Society

Focusing on two immigrant populations and their relationships with their native neighbours in Thessaloniki, Greece, this paper highlights that immigrant–native relations are not only cultural relations but also power configurations unfolding through a symbolic contestation over defining the nation and who belongs to it. In everyday interaction, immigrants' behaviour is judged by natives according to the degree of their compliance to the native norms. Immigrant categories are endowed with different resources in resisting the pressure exerted by the native society. Categories that have more resources in symbolic and substantial terms are less eager to comply, thus appearing more ‘different’ in the eyes of the natives.
Comments on voluntarism: reply to Penk and Robinowitz.

Two articles on tests of the voluntarism hypothesis by Penk and Robinowitz (1976; 1980) suggest that these investigators are convinced that voluntarism is a variable of importance in influencing self-reported psychopathology. In contrast, Sutker, Archer, and Allain (1979), without minimizing the potential effects of voluntarism per se, cautioned that its influence may be modified, if not overshadowed, by person-context characteristics across different settings and among varied groups of drug-dependent individuals (e.g., veteran/nonveteran addicts, chronic opiate/polydrug addicts) and by the consequences of not volunteering for treatment. We suggested that situational, environmental, or physiological factors associated with the street life or long-term use of illicit drugs, as well as the specific conditions of testing or addict perceptions of such, may be more critical than voluntarism in affecting selfreported psychopathology. We also commented that voluntarism may prove important in predicting successfulness of drug abuse treatment participation and outcome. Although Penk and Robinowitz (1980) turned attention to the treatment implications of voluntarism, the lengths to which they extend themselves to argue the powerfulness of this variable are surprising. Penk and Robinowitz (1980) took the Sutker et al. (1979) research to task for methodological flaws and suggested that the time had come to move forward from "preexperimental" research to use of "true experimental design. " This is a vulnerable stance in view of the general type of research conducted, problems in design conceptualization, and methodological flaws in their 1980 article. First, we suggest that for Penk and Robinowitz (1980) to label their design as "true" or "experimental" is inappropriate as defined by Campbell and Stanley (1963). Penk and Robi-
Gender-stereotype Accuracy as an individual difference

Accuracy of participants' ratings of gender differences on 77 behaviors and traits was assessed by correlating participants' ratings with actual gender differences based on meta-analyses, Accuracy at the group level was impressively high in 5 samples of participants. Accuracy of individuals showed wide variability, suggesting that ability to accurately describe gender differences is an individual difference. Analysis of correlations between individual accuracy and a battery of psychological measures indicated that accuracy was negatively related to a tendency to accept and use stereotypes, negatively related to a rigid cognitive style, and positively related to measures of interpersonal sensitivity.
Learning to Generate Sequences with Combination of Hebbian and Non-hebbian Plasticity in Recurrent Spiking Neural Networks

Synaptic Plasticity, the foundation for learning and memory formation in the human brain, manifests in various forms. Here, we combine the standard spike timing correlation based Hebbian plasticity with a non-Hebbian synaptic decay mechanism for training a recurrent spiking neural model to generate sequences. We show that inclusion of the adaptive decay of synaptic weights with standard STDP helps learn stable contextual dependencies between temporal sequences, while reducing the strong attractor states that emerge in recurrent models due to feedback loops. Furthermore, we show that the combined learning scheme suppresses the chaotic activity in the recurrent model substantially, thereby enhancing its' ability to generate sequences consistently even in the presence of perturbations.
Inflation Targeting in a Learning Economy: An ABM Perspective

This paper investigates the performances of an inflation targeting regime in a learning economy framed as an Agent-Based Model (ABM). We keep our ABM as close as possible to the original New Keynesian (NK) model, but we model the individual behaviour of the agents under procedural rationality a la Simon. Accordingly, we assume that their behaviour is guided by simple rules of thumb – or heuristics – while a continuous learning process governs the evolution of those rules. Under these assumptions that also allow the emergence of agents heterogeneity, we analyze the dynamics of the economy without assuming rational expectations, and study the role that a central bank, implementing an inflation targeting regime via a monetary policy rule, can play in the orientation of these dynamics. Consequently, our main goal is to analyse the interplay between the learning mechanisms operating at the individual level and the features and performances of the inflation targeting regime. Our results point to the prime importance of the credibility of central bank's inflation target regarding macroeconomic stabilisation, as well as the beneficial role played by that target as an anchoring device for private inflation expectations. We also establish the potential welfare cost of imperfect public information and contribute to the current debate on optimal monetary policy rules under imperfect common knowledge and uncertainty.
Sums Involving Moments of Reciprocals of Binomial Coefficients

We investigate sums of the form P 0�kn k m n k � 1 . We establish a recurrence re- lation and compute its ordinary generating function. As application we give the asymptotic expansion. The results extend the earlier works by various authors. In the last section, we establish that P 0�kn k m nm n k � 1 tends to 1 as n ! 1 and that P 0�kn m k m n k � 1 tends to m! as n ! 1.
Parents' Experience of the Diagnostic Process for Autistic Spectrum Disorders

Parental perceptions of receiving a diagnosis for their child have been widely researched, with results suggesting high levels of dissatisfaction. Such research has focused upon diagnoses such as Down syndrome and cerebral palsy, and has often looked specifically at the disclosure of a diagnosis. There is limited research looking at the process associated with receiving a diagnosis of an autism spectrum disorder (ASD); that is, from sharing initial concerns to receiving support and intervention. This study aimed to document parents' experiences of the diagnostic process for ASD. A sample of participants was selected, according to set criteria, from an Education and Library Board database in Northern Ireland. Eleven parents agreed to be interviewed at home, using a semi-structured interview schedule, on their experiences of ASD diagnostic procedures. Qualitative responses were analysed using thematic analysis. Data were also presented descriptively. Results suggested that the majority of parents had positive comments about the assessment and diagnostic experience. Parents cited several points as contributing to their overall experience with the process. These included having their initial concerns listened to, receiving their child's diagnosis in person, receiving written information and help in applying this information. This report provides a valuable insight into parental experiences of receiving an ASD diagnosis for their child. Key findings highlight the complexity of the diagnostic process for both practitioners and families involved, and therefore may have implications for practice. This is further discussed in the report.
ORGANIZATIONAL SOCIALIZATION IN THE HOST COUNTRY: THE MISSING LINK IN REDUCING EXPATRIATE TURNOVER

The socialization process of expatriates into their host country organizational culture has been largely ignored in the expatriate literature. This paper reviews the expatriate literature for the best employee and organizational results. For the most part, socialization tactics of the organization and information seeking of the individual have been overlooked as factors in the success of expatriates. We propose that combining knowledge gained through research in these two areas is essential in gaining a theoretical understanding of expatriate turnover. The Attraction‐Selection‐Attrition (ASA) model of how organizational culture is transmitted across organizational members is discussed. This model is used to demonstrate how the socialization of expatriates can benefit both the organization and the individual.
A Pilot Study to Explore the Effect of Symptom Monitoring in Children and Adolescents with Posttraumatic Stress Reactions following Road Traffic Accidents

Abstract Each year a large number of children and adolescents develop significant posttraumatic symptoms after being involved in road traffic accidents (RTA). Consequently there is a need to develop effective interventions to prevent or minimize such reactions. The use of symptom monitoring with adults has found promising results. This pilot study explores the use of symptom monitoring with children and young people involved in RTAs. Twelve young people who met criteria on screening questionnaires for significant posttraumatic symptoms completed symptom monitoring diaries. Following completion of a diary once a day for 3 weeks, 3/12 children (25%) fell below criteria, suggesting significant posttraumatic symptoms. Feedback about self-monitoring was generally positive and suggests that symptom monitoring may be a helpful yet simple intervention for use with child trauma victims.
Difficulties in initiating and sustaining peer friendships : perspectives on students diagnosed with AD/HD

In this article, Myra Taylor, research fellow, and Professor Stephen Houghton of the Centre for Child and Adolescent Related Disorders at the University of Western Australia, report theory generated from interviews with teachers, students and mothers residing in Perth, Western Australia, on how children with attention-deficit/hyperactivity disorder (AD/HD) initiate and sustain peer relationships. An initial review of the three sample groups’ respective perspectives reveals that children with AD/HD exhibit three distinct socialisation patterns: a socially integrated pattern (that is, having three or more ongoing friendship pairings with peers); a marginal integrated pattern (that is, having two or less ongoing friendship pairings with peers); and a socially isolated pattern (that is, having no, or infrequent, friendship pairings with peers). Both teacher and maternal perspectives are similar in so far as both perceive children with attention deficit disorders to have marginal to non-existent friendships. Students with AD/HD perceive themselves, however, as having strongly to marginally formed friendships with their peers. Myra Taylor and Stephen Houghton explore suggestions that differences between adult and child perspectives relate to diagnostic status, age and developmental maturity. They identify opportunities for further research arising out of their work and indicate that a wider evidence base will be needed before robust recommendations for practice can be made.
Prototypical Affective Microsequences in Psychotherapeutic Interaction

In this article a new approach for the microanalytic study of cognitive-affective regulatory processes in psychotherapeutic interaction is presented. Of central importance are the communicative components of affective regulatory processes that are directly observable, particularly facial expressions which were coded with the Facial Action Coding System (FACS) by Ekman and Friesen (1978). These data are represented graphically in the form of a process pilot and related to theoretical concepts about affective regulatory processes in such a way that an integrated model of the affective regulatory processes can be formulated for selected sequences. Such sequences are designated prototypical affective microsequences. Their role in the affective regulation of client-therapist interaction is worked out and discussed by means of an example. It can be shown that so-called successful microsequences with often-recurring smiles and laughter of both client and therapist are necessary to give the client a basic sense o.
Historiography for the new millennium: adventures in accounting and management

This paper reflects upon the status of historical research in the contemporary accounting and management research literature, briefly revisits some of its fundamental methodological dimensions and considers the multiple potential roles which it has the capacity to fulfill. The author then selects a number of methodological and research subjects which show signs of maintaining their momentum or deserve experimentation or increased application. These include the historical narrative, “macro” literary style narrative histories, business history lessons for accounting and management history, critical theory informed research, emerging social history, and opportunities for research employing oral and visual history. The paper concludes with reflections on the dividends for the individual historian and the historical research community that may accrue from opportunities taken up in the new millennium.
The Effects of Feedback on Perseverative Errors in Preschool Aged Children

Research using the Dimensional Change Card Sort (DCCS) showed that young children are usually able to sort accurately by an initial rule but are unable to switch to a new rule when the two rules conflict. In 2 experiments, the DCCS was modified to study the effects of feedback on 3- to 5-year-old children in a problem-solving task. In Experiment 1, half of the children in each of two age groups (36 to 44 months and 52 to 60 months) were administered the DCCS task using the standard (no feedback) procedure and the other half received feedback on their post-switch responses. Children who received feedback were able to categorize according to the new (correct) rule, whereas the children in the younger age group who did not receive feedback continued to perseverate. Experiment 2 with 3-year-olds replicated the results from Experiment 1 but found that children's successful performance with feedback on the card-sorting task did not lead to improved performance on the post-switch phase of a subsequent DCCS task. Successful performance under conditions of feedback in both studies implies that 3-year-olds are capable of shifting their response mode from one rule to an alternate rule under conditions that offer clear guidance. Poor performance on the standard version is interpreted to be a reflection of the inability to monitor their own task performance in the absence of clear contextual cues.
Condições de vida, gênero e saúde mental entre trabalhadoras rurais assentadas

O presente estudo teve como objetivo investigar a prevalencia de transtornos mentais comuns (TMC) e os possiveis fatores relacionados a emergencia de tais transtornos entre mulheres residentes de um assentamento rural do Rio Grande do Norte. Trata-se de uma pesquisa de carater quantitativo e qualitativo de inspiracao etnografica. Como estrategias metodologicas, fizemos uso de questionario socio-demografico-ambiental, do instrumento de rastreamento em saude mental Self-Reporting Questionnaire (SRQ-20) e de entrevista semiestruturada com as participantes. Os resultados apontam para a alta prevalencia de TMC (43,6%) entre as assentadas e sugerem a articulacao entre pobreza, violencia de genero, sobrecarga laboral e a ocorrencia de TMC.
Substitution Patterns Are GC-Biased in Divergent Sequences across the Metazoans

The fastest-evolving regions in the human and chimpanzee genomes show a remarkable excess of weak (A,T) to strong (G,C) nucleotide substitutions since divergence from their common ancestor. We investigated the phylogenetic extent and possible causes of this weak to strong (W→S) bias in divergent sequences (BDS) using recently sequenced genomes and recombination maps from eight trios of eukaryotic species. To quantify evidence for BDS, we inferred substitution histories using an efficient maximum likelihood approach with a context-dependent evolutionary model. We then annotated all lineage-specific substitutions in terms of W→S bias and density on the chromosomes. Finally, we used the inferred substitutions to calculate a BDS score—a log odds ratio between substitution type and density—and assessed its statistical significance with Fisher's exact test. Applying this approach, we found significant BDS in the coding and noncoding sequence of human, mouse, dog, stickleback, fruit fly, and worm. We also observed a significant lack of W→S BDS in chicken and yeast. The BDS score varies between species and across the chromosomes within each species. It is most strongly correlated with different genomic features in different species, but a strong correlation with recombination rates is found in several species. Our results demonstrate that a W→S substitution bias in fast-evolving sequences is a widespread phenomenon. The patterns of BDS observed suggest that a recombination-associated process, such as GC-biased gene conversion, is involved in the production of the bias in many species, but the strength of the BDS likely depends on many factors, including genome stability, variability in recombination rate over time and across the genome, the frequency of meiosis, and the amount of outcrossing in each species.
The social dimensions of correctional officer stress

Based on a survey of line staff in a southern correctional system, we analyzed how various stressors, coping factors, and status characteristics influenced three types of stress: work stress, job dissatisfaction, and life stress. The stressors of role problems and perceived dangerousness were positively related to multiple forms of stress. While supervisory support mitigated both work stress and job dissatisfaction, the effects of other coping factors were variable. Black and educated officers had higher levels of dissatisfaction, while female officers experienced more stress on the job. Taken together, the independent variables in our framework accounted for a large amount of the variance of work stress, a moderate amount of job dissatisfaction, and a relatively low amount of life stress. Apart from the specific findings, the data suggest that theoretical models of officer stress must incorporate coping factors and specify how the dimensions of an officer's occupational role and personality differentiall.
Factors affecting vascular access complications in children undergoing congenital cardiac catheterization

Abstract Background Complications at the vascular access sites are among the most common adverse events in congenital cardiac catheterization. The use of small-gauge catheters may reduce these events; however, other factors can contribute to the development of vascular complications. Objectives To determine factors associated with the development of vascular access complications in children undergoing congenital cardiac catheterization. Methods We performed a prospective study of 403 patients who underwent diagnostic (62.5%) or interventional (37.5%) cardiac catheterization over a period of 6 months, and analysed the vascular complications during and immediately after the procedure. Results The most common access-related adverse event was transient loss of pulsation (17.6%). Other less common access-related adverse events included subcutaneous haematoma (2%), bleeding (3%), vessel tear (0.2%), and vein thrombosis (0.2%). Patients who had no access-related adverse events had significantly higher age and body weight compared with those who had one or more access problems. Among 81 patients who had vascular access established in unplanned access sites, 30 patients (37%) had lost pulsations. Among the 322 patients who had vascular access established in planned access sites, however, only 41 patients had lost pulsation (13%). In addition, patients who had lost pulsations had significantly longer puncture time compared to those who had normal pulsations (p value 0.01). Conclusion Factors other than sheath size can contribute to access-related adverse events in children undergoing cardiac catheterization. Obtaining vascular access in unplanned access sites and longer puncture times increases the incidence of lost pulsations after catheterization. Younger age and smaller body weight are also associated with significant increase in access-related adverse events.