Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic Coding for Flexible Cognitive Control

A hallmark of cognitive control is its flexibility. Every situation we experience is essentially unique, and yet we are able to act appropriately in different contexts, integrating the current environmental contingencies, our internal goals, and the goals of those around us. Imagine sitting down to play a new card game—you are able to integrate the rules; form an initial, possibly rudimentary, strategy; and then play your hand appropriately. On top of this incredible ability to coordinate complex rule‐guided goal‐directed behaviour, we can quickly change our behaviour in response to changes in the world around us or our own desires. Behavioural studies suggest this can happen extremely quickly—within a couple of hundred milliseconds (for a review, see Sakai, 2008). For example, you will likely adapt your strategy as you play the game, learn its nuances, and respond to the strategies of others—perhaps even before the next hand is played. What are the neural mechanisms that support this flexibility? In this chapter, we suggest that cognitive flexibility depends on the capacity of the prefrontal cortex (PFC) to dynamically encode the task‐relevant information. We begin by reviewing the evidence that the l ateral PFC (lPFC) plays a particularly important role in flexible cognitive control. Next, we review the evidence for highly dynamic representations in lPFC. Finally, we consider how these r epresentations can be used to establish task‐relevant networks throughout the brain.
Technology as Experience

Technology permeates all aspects of our lives: the Apple Powerbook I happily use to compose this review, the automated voice on the subway that soothingly announces “next stop Belmont” on my commute, and the climate control system in my office that always leaves me with cold fingers as I type. As John McCarthy and Peter Wright, the authors of Technology as Experience, explain, “much more deeply than ever before, we are aware that interacting with technology involves us emotionally, intellectually and sensually. We don’t just use technology; we live with it” [p. ix].
A Minimax Approach to Supervised Learning

Given a task of predicting $Y$ from $X$, a loss function $L$, and a set of probability distributions $\Gamma$ on $(X,Y)$, what is the optimal decision rule minimizing the worst-case expected loss over $\Gamma$? In this paper, we address this question by introducing a generalization of the principle of maximum entropy. Applying this principle to sets of distributions with marginal on $X$ constrained to be the empirical marginal from the data, we develop a general minimax approach for supervised learning problems. While for some loss functions such as squared-error and log loss, the minimax approach rederives well-knwon regression models, for the 0-1 loss it results in a new linear classifier which we call the maximum entropy machine. The maximum entropy machine minimizes the worst-case 0-1 loss over the structured set of distribution, and by our numerical experiments can outperform other well-known linear classifiers such as SVM. We also prove a bound on the generalization worst-case error in the minimax approach.
The affective underpinnings of job perceptions and attitudes: a meta-analytic review and integration.

Using psychometric meta-analysis, the authors present a quantitative and qualitative review (k = 205, total pairwise N = 62,527) of the literature relating trait and state positive affect (PA) and negative affect (NA) to job-related attitudes, including job satisfaction, organizational commitment, turnover intentions, and dimensions of job burnout. Results indicated substantial correlations, ranging in absolute value from -. 17 (PA and turnover intentions; NA and personal accomplishment) to.54 (NA and emotional exhaustion). Correlational results largely were consistent across hypothesized and exploratory moderator conditions. Meta-analytic multiple regression results generally supported the unique contribution of each affect to each attitude variable of interest. Implications and suggestions for future research on emotion-related aspects of job attitudes are discussed.
What can quantum optics say about complexity theory?

Considering the problem of sampling from the output photon-counting probability distribution of a linear-optical network for input Gaussian states, we obtain results that are of interest from both quantum theory and the computational complexity theory point of view. We derive a general formula for calculating the output probabilities, and by considering input thermal states, we show that the output probabilities are proportional to permanents of positive-semidefinite Hermitian matrices. It is believed that approximating permanents of complex matrices in general is a #P-hard problem. However, we show that these permanents can be approximated with an algorithm in the BPP^{NP} complexity class, as there exists an efficient classical algorithm for sampling from the output probability distribution. We further consider input squeezed-vacuum states and discuss the complexity of sampling from the probability distribution at the output.
Teratological assessment of stobadine after single and repeated administration in mice

Teratological studies were performed with stobadine, a compound with antiarrhythmic and antihypoxic activity. Single i.v. injections of stobadine in the form of dihydrochloride (DH 1011) to ICR mice on days 3, 6, 9 or 12 of gestation at doses of 1 and 3 mg kg−1 had no teratogenic effect. Slight fetal toxicity was manifested by decreased fetal weight after treatment on days 3 and 6, increased incidence of rudimentary ribs after treatment on days 9 and 12 of gestation and non‐significantly increased postimplantation loss after injection on day 6 of gestation. The effect of repeated oral administration in the form of dipalmitate salt (DP 1031) was studied in doses of 12.2, 61.0 and 122.0 mg kg−1 on days 4–16 of gestation. Oral exposure to 61.0 mg kg−1 DP 1031 resulted in significant reduction of implantations, live fetuses and litter weight, and after 122.0 mg kg−1 DP 1031 the fetal weight was significantly decreased. External and skeletal examinations of the fetuses revealed no evidence of teratogenesis. The relevance of the two routes of stobadine administration for risk involvement is discussed.
Characterization of Tetrahymena Histone H2B Variants and Posttranslational Populations by Electron Capture Dissociation (ECD) Fourier Transform Ion Cyclotron Mass Spectrometry (FT-ICR MS)*S

This work describes the nature and sequence information content of the electron capture dissociation mass spectra for the intact Tetrahymena histone H2B. Two major variants of this protein were present bearing nominal modifications of both +42 and +84 Da. This work describes identification of the nature of these two modifications. For example, using gas-phase selection and isolation of the +42-Da modified species, from a background of two H2B variants each present in six or more posttranslationally modified isoforms, we were able to determine that this +42-Da modification isoform bears trimethylation rather than acetylation. LC-CIDMS analysis was also employed on digested preparations to obtain complementary detail of the nature of site-specific posttranslational modifications. This study establishes that integration of the information from these two datasets provides a comprehensive map of posttranslational occupancy for each particular covalent assemblage selected for structural investigation.
TESTING PROXIMAL AND DISTAL PROTECTIVE PROCESSES IN PRETERM HIGH-RISK CHILDREN

The purpose was to examine a model that incorporates cumulative medical risk at age 4 and distal and protective processes at age 8 to assess school-age competency outcomes of cognition, school achievement, and socioemotional well-being in a sample of preterm children born at various degrees of medical risk. Cumulative medical risk and distal protective and proximal maternal protective processes were constructed into indexes. Hierarchical multiple regression analysis were performed entering the cumulative medical risk index first, followed by distal and proximal protective processes in the next two steps to test the effect on cognitive, academic, and socioemotional competence. For participants, 151 preterm and 39 full-term infants were recruited at birth into a prospective longitudinal study and followed until age 8 with a 97% retention rate. Children were stratified by birth weight and socioeconomic status. The hypotheses were supported. Significant main effects for cumulative medical risk and distal and proximal protective processes in all competency outcome models are key findings. The addition of protective processes was small to moderate in effect (6%-18%) yet clinically significant. These findings illustrate the advantage of applying cumulative medical risk and protection approach to better understand school-age outcomes. Multiple risk and protective models emphasize the joint occurrence of individual contextual processes in the understanding of competence outcomes in high-risk children.
Generalized Topological Simplification of Scalar Fields on Surfaces

We present a combinatorial algorithm for the general topological simplification of scalar fields on surfaces. Given a scalar field f, our algorithm generates a simplified field g that provably admits only critical points from a constrained subset of the singularities of f, while guaranteeing a small distance ||f - g||∞ for data-fitting purpose. In contrast to previous algorithms, our approach is oblivious to the strategy used for selecting features of interest and allows critical points to be removed arbitrarily. When topological persistence is used to select the features of interest, our algorithm produces a standard ϵ-simplification. Our approach is based on a new iterative algorithm for the constrained reconstruction of sub- and sur-level sets. Extensive experiments show that the number of iterations required for our algorithm to converge is rarely greater than 2 and never greater than 5, yielding O(n log(n)) practical time performances. The algorithm handles triangulated surfaces with or without boundary and is robust to the presence of multi-saddles in the input. It is simple to implement, fast in practice and more general than previous techniques. Practically, our approach allows a user to arbitrarily simplify the topology of an input function and robustly generate the corresponding simplified function. An appealing application area of our algorithm is in scalar field design since it enables, without any threshold parameter, the robust pruning of topological noise as selected by the user. This is needed for example to get rid of inaccuracies introduced by numerical solvers, thereby providing topological guarantees needed for certified geometry processing. Experiments show this ability to eliminate numerical noise as well as validate the time efficiency and accuracy of our algorithm. We provide a lightweight C++ implementation as supplemental material that can be used for topological cleaning on surface meshes.
The relationship between the local and systemic inflammatory responses and survival in patients undergoing resection for localized renal cancer

To examine the relationship between the systemic inflammatory response (C‐reactive protein, CRP), tumour interleukin‐6 receptor and cyclooxygenase (COX)‐2 expression, tumour T‐lymphocytic (CD4+, CD8+) infiltration and cancer survival in patients undergoing resection for renal cell carcinoma (RCC), as both the local and systemic inflammatory responses appear to predict the outcome in these patients.
Unexpected Role of B and T Lymphocyte Attenuator in Sustaining Cell Survival during Chronic Allostimulation

B and T lymphocyte attenuator (BTLA; CD272) can deliver inhibitory signals to B and T cells upon binding its ligand herpesvirus entry mediator. Because CD28, CTLA-4, programmed death-1, and ICOS regulate the development of acute graft-vs-host disease (GVHD), we wished to assess if BTLA also played a role in this T cell-mediated response. In the nonirradiated parental-into-F1 model of acute GVHD, BTLA+/+ and BTLA−/− donor lymphocytes showed equivalent engraftment and expansion during the first week of the alloresponse. Unexpectedly, BTLA−/− donor T cells failed to sustain GVHD, showing a decline in surviving donor cell numbers beginning at day 9 and greatly reduced by day 11. Similarly, inhibition of BTLA-herpesvirus entry mediator engagement by in vivo administration of a blocking anti-BTLA Ab also caused reduced survival of donor cells. Microarray analysis revealed several genes that were differentially expressed by BTLA−/− and BTLA+/+ donor CD4+ T cells preceding the decline in BTLA−/− donor T cells. Several genes influencing Th cell polarization were differentially expressed by BTLA+/+ and BTLA−/− donor cells. Additionally, the re-expression of the IL-7Rα subunit that occurs in BTLA+/+ donor cells after 1 wk of in vivo allostimulation was not observed in BTLA−/− donor CD4+ cells. The striking loss of BTLA−/− T cells in this model indicates a role for BTLA activity in sustaining CD4+ T cell survival under the conditions of chronic stimulation in the nonirradiated parental-into-F1 GVHD.
Monoclonal antibody characterization of two distant sites required for function of the central cell-binding domain of fibronectin in cell adhesion, cell migration, and matrix assembly

Site-directed mutagenesis studies have suggested that additional peptide information in the central cell-binding domain of fibronectin besides the minimal Arg-Gly-Asp (RGD) sequence is required for its full adhesive activity. The nature of this second, synergistic site was analyzed further by protein chemical and immunological approaches using biological assays for adhesion, migration, and matrix assembly. Fragments derived from the cell-binding domain were coupled covalently to plates, and their specific molar activities in mediating BHK cell spreading were compared with that of intact fibronectin. A 37-kD fragment purified from chymotryptic digests of human plasma fibronectin had essentially the same specific molar activity as intact fibronectin. In contrast, other fragments such as an 11.5-kD fragment lacking NH2- terminal sequences of the 37-kD fragment had only poor spreading activity on a molar basis. Furthermore, in competitive inhibition assays of fibronectin-mediated cell spreading, the 37-kD fragment was approximately 325-fold more active than the GRGDS synthetic peptide on a molar basis. mAbs were produced using the 37-kD protein as an immunogen and their epitopes were characterized. Two separate mAbs, one binding close to the RGD site and the other to a site approximately 15 kD distant from the RGD site, individually inhibited BHK cell spreading on fibronectin by greater than 90%. In contrast, an antibody that bound between these two sites had minimal inhibitory activity. The antibodies found to be inhibitory in cell spreading assays for BHK cells also inhibited both fibronectin-mediated cell spreading and migration of human HT-1080 cells, functions which were also dependent on function of the alpha 5 beta 1 integrin (fibronectin receptor). Assembly of endogenously synthesized fibronectin into an extracellular matrix was not significantly inhibited by most of the anti-37-kD mAbs, but was strongly inhibited only by the antibodies binding close to the RGD site or the putative synergy site. These results indicate that a second site distant from the RGD site on fibronectin is crucial for its full biological activity in diverse functions dependent on the alpha 5 beta 1 fibronectin receptor. This site is mapped by mAbs closer to the RGD site than previously expected.
C-reactive protein in outpatients with acute exacerbation of COPD: its relationship with microbial etiology and severity

Background C-reactive protein (CRP) measurement has proven valuable for detecting exacerbations, but its usefulness in predicting etiology remains controversial. Likewise, its potential value as a marker of severity, which is well established in patients with pneumonia, remains unproven in chronic obstructive pulmonary disease (COPD) exacerbations. Methods A cohort study of 118 patients with severe COPD and acute infectious exacerbations were included and followed up over 1 year. Episodes of exacerbations meeting Anthonisen’s criteria type I–II were evaluated, analyzing the etiology and inflammatory response as measured by CRP in blood. Results A total of 380 episodes were recorded. Full microbiological analysis was available in 265 samples. Haemophilus influenzae was the most commonly isolated bacteria and rhinovirus the most common virus. Median CRP levels from the 265 episodes were higher in the cases with positive cultures for bacteria (58.30 mg/L, interquartile range [IQR] 21.0–28.2) than in episodes only positive for viruses (37.3 mg/L, IQR 18.6–79.1) and cases negative for any microorganism (36.4 mg/L, IQR 10.8–93.7) (P<0.014). H. influenzae and Streptococcus pneumoniae reached the highest CRP levels of 74.5 mg/L (IQR 23.9–167.9) and 74.1 mg/L (IQR 42.0–220.7), respectively. In the 380 exacerbations studied, 227 (~60%) were community-managed, while 153 (~40%) required hospital admission. In the multivariate analysis to assess the influence of inflammatory response on exacerbation severity, baseline hypercapnia (odds ratio [OR]: 2.70, 95% confidence interval [CI]: 1.46–4.9) and CRP levels >100 mg/L (OR: 4.23, 95% CI: 2.12–8.44) were independent predictors after adjustment for baseline characteristics. Conclusion CRP level was higher in bacterial infections, especially when H. influenzae and S. pneumoniae were isolated. CRP values >100 mg/L were associated with a fourfold increased risk of hospital admission. Therefore, CRP blood levels may be a useful biomarker in the management of exacerbations appearing in patients with severe disease.
Effect of Cage-Induced Stereotypies on Measures of Affective State and Recurrent Perseveration in CD-1 and C57BL/6 Mice

Stereotypies are abnormal repetitive behaviour patterns that are highly prevalent in laboratory mice and are thought to reflect impaired welfare. Thus, they are associated with impaired behavioural inhibition and may also reflect negative affective states. However, in mice the relationship between stereotypies and behavioural inhibition is inconclusive, and reliable measures of affective valence are lacking. Here we used an exploration based task to assess cognitive bias as a measure of affective valence and a two-choice guessing task to assess recurrent perseveration as a measure of impaired behavioural inhibition to test mice with different forms and expression levels of stereotypic behaviour. We trained 44 CD-1 and 40 C57BL/6 female mice to discriminate between positively and negatively cued arms in a radial maze and tested their responses to previously inaccessible ambiguous arms. In CD-1 mice (i) mice with higher stereotypy levels displayed a negative cognitive bias and this was influenced by the form of stereotypy performed, (ii) negative cognitive bias was evident in back-flipping mice, and (iii) no such effect was found in mice displaying bar-mouthing or cage-top twirling. In C57BL/6 mice neither route-tracing nor bar-mouthing was associated with cognitive bias, indicating that in this strain these stereotypies may not reflect negative affective states. Conversely, while we found no relation of stereotypy to recurrent perseveration in CD-1 mice, C57BL/6 mice with higher levels of route-tracing, but not bar-mouthing, made more repetitive responses in the guessing task. Our findings confirm previous research indicating that the implications of stereotypies for animal welfare may strongly depend on the species and strain of animal as well as on the form and expression level of the stereotypy. Furthermore, they indicate that variation in stereotypic behaviour may represent an important source of variation in many animal experiments.
Stochastic Rate Control for Scalable VBR Video Streaming over Wireless Networks

Video streaming over wireless links is a challenging problem due to both the unreliable, time-varying nature of the wireless channel and the stringent delivery requirements of media traffic. Layered encoded video can be used to improve the system performance by adapting the sending rate for different video frame layers to the varying network and playout situations. In this paper, we study the adaptive control of sending rates for both the base layer and enhancement layer based on feedback information from the wireless receiver. We formulate the problem in a framework of Markov decision processes to minimize a weighted sum of video quality and playout continuity degradation. In order to decrease the computation complexity, we then develop an online greedy algorithm, which only considers the current control time period. Simulation results show that the propose adaptive rate control provides significantly improved video quality and playout smoothness. Furthermore, when rate control is not performed very frequently, the greedy algorithm achieves a video distortion rate nearly matching that of the ideal optimal Dynamic Programming policy.
GABAergic and glycinergic IPSCs in Ganglion Cells of Rat Retinal Slices

GABAergic and glycinergic IPSCs were studied in identified retinal ganglion cells (RGCs) of light-adapted rat retinal slices, using whole-cell recording techniques. GABAergic IPSCs were blocked specifically by SR95531 (3 μm) and bicuculline (3 μm) and glycinergic IPSCs by strychnine (0.3 μm). From 37 RGCs studied, 25 showed exclusively GABAergic IPSCs, 6 presented only glycinergic IPSCs, and 6 showed both. This distribution may result from differences in amacrine cells input rather than from receptor heterogeneity, because both GABA and glycine elicited Cl−-selective currents in all RGCs tested. TTX markedly reduced GABAergic IPSCs frequency, whereas glycinergic IPSCs were unaffected. Ca2+-free media, with or without high Mg2+, blocked TTX-resistant GABAergic and glycinergic IPSCs. These results suggest that GABAergic IPSCs in RGCs can be elicited either by Na+-dependent action potentials or by local Ca2+ influx in medium or large dendritic field GABAergic amacrine cells, whereas glycinergic IPSCs are generated by action potential-independent Ca2+ influx in narrow field glycinergic amacrine cells. Both types of IPSCs had fast rise times and biexponential decays, but glycinergic IPSC decay was significantly slower than that of GABAergic IPSCs. An elementary conductance of 54 pS for the glycine-gated channels was estimated from single-channel events, clearly detected in the falling phase of glycinergic IPSCs, and from responses to exogenous glycine.
Template-based privacy preservation in classification problems

In this paper, we present a template-based privacy preservation to protect against the threats caused by data mining abilities. The problem has dual goals: preserve the information for a wanted classification analysis and limit the usefulness of unwanted sensitive inferences that may be derived from the data. Sensitive inferences are specified by a set of "privacy templates". Each template specifies the sensitive information to be protected, a set of identifying attributes, and the maximum association between the two. We show that suppressing the domain values is an effective way to eliminate sensitive inferences. For a large data set, finding an optimal suppression is hard, since it requires optimization over all suppressions. We present an approximate but scalable solution. We demonstrate the effectiveness of this approach on real life data sets.