Miracle-dz/UniFAR-FTUs huggingface dataset:
SVM-Based Efficient QoS-Aware Runtime Adaptation for Service Oriented Systems

Given the increase in web services, Quality of Service (QoS) attributes have been widely addressed. In dynamic Internet environment, service providers rarely deliver the QoS as declared. Runtime adaptations of execution plans become necessary in order to recovery from web service failures, maintain SLAs, and/or continuously improve the overall QoS attributes. As QoS-aware service composition methods are mainly employed to fulfill runtime adaptations, the time efficiency usually becomes a challenge since the execution of a composite application is blocked until the new execution plan is found. Although existing works have provided high-quality methods to deal with QoS-aware service composition at design time, a suitable mechanism has not been established to utilize these methods coping with runtime adaptations in an efficient way. In this paper, we propose a novel empirical approach to accelerate QoS-aware runtime adaptation. Based on historical records, our approach uses Support Vector Machines (SVMs) to capture the relationship between candidate services and adaptation scenarios which are used at runtime to predict the probabilities that candidate services will be used for upcoming adaptation scenarios. Then candidate services are pruned based on these probability estimates to reduce the search space. The experimental results revealed the proposed approach can achieve significantly acceleration while satisfying considerable correctness.
Continuous therapeutic ultrasound accelerates repair of contraction-induced skeletal muscle damage in rats.

OBJECTIVE To examine the effect of ultrasonography on the repair of muscle injured through repeated eccentric contractions. DESIGN Randomized, case-control study. SETTING Laboratory animal facility. ANIMALS Thirty-three Sprague-Dawley rats. INTERVENTIONS Specimens were anesthetized and each foot strapped, in turn, onto a motorized foot pedal, which moved the ankle repeatedly through a range of 110 degrees. Extensor digitorum longus muscles were injured by stimulating the peroneal nerve during foot plantarflexion. Continuous 1.0MHz ultrasound treatments at 0.5W/cm(2) were applied through water submersion technique to 1 limb daily for 3, 5, or 7 days postinjury. The contralateral limb served as an injured control. MAIN OUTCOME MEASURES Extensor digitorum longus maximum isometric tetanic force (P(o)) was measured in vitro from all extensor digitorum longus muscles and used as a functional index of muscle injury. RESULTS Analysis of variance and Tukey post hoc analysis showed no significant differences in P(o) between treated and untreated limbs at 3 and 5 days, but at 7 days postinjury, P(o) of ultrasound-treated muscle was significantly higher than was untreated muscle. CONCLUSION Seven days of continuous therapeutic ultrasound improved force production after contraction-induced muscle injury.
Quality of Physical and Sensory of Super-native Chicken Breast Marinated with Herbs and Spices with Different Levels of Marination Concentration

Super-native chickens result from crosses between male native chickens and laying hens. Â The diversification of processed products from super-native chicken can be developed into ready-to-cook products by marinating them with local herbs and spices. Â This research was conducted on the effect of marination concentrations of different local herbs and spices on the hedonic quality of super-native chicken breast. Â The research material consisted of super-native chicken breast, chili powder, sugar, salt, pepper, garlic, cinnamon, palm oil, lime juice, monosodium glutamate, and ginger. Â The treatment levels of marination concentration were 10, 20, and 30% of the weight of the meat. Â Physical quality parameters tested were color, pH value, moisture, cooking loss, water-holding capacity, yield, and hardness. Â Each treatment consisted of 3 replications. Â In addition, sensory quality was tested by a hedonic quality test by 40 untrained panelists. Â The hedonic quality parameters tested were color, flavor, taste, texture, tenderness, and juiciness. Â The data from the physical quality test were analyzed by analysis of variance. Â The hedonic quality test results were analyzed by non-parametric analysis through the Kruskal-Wallis hedonic test. Â If there was a significant difference (P0.05), the test was continued with Duncan's New Multiple Range Test. Â The results showed that the concentration level of different local herbs and spices marination could affect the physical quality (redness, pH value, and moisture) and sensory (color and texture) of super-native chicken breast. Â The marination concentration of local herbs and spices at 20% level was the best treatment based on hedonic quality with a smooth meat texture and a score of 3.98.
The Cluster Basis of Z[x1,1,...,x3,3]

We show that the set of cluster monomials for the cluster algebra of type D4 contains a basis of the Z-module Z[x1;1; : : : ; x3;3]. We also show that the transition matrices relating this cluster basis to the natural and the dual canonical bases are unitriangular and nonnegative. These results support a conjecture of Fomin and Zelevinsky on the equality of the cluster and dual canonical bases. In the event that this conjectured equality is true, our results also imply an explicit factorization of each dual canonical basis element as a product of cluster variables.
Online video-based sequence synchronization for moving camera object detection

This work presents a video-based sequence synchronization algorithm to be used in real-time video surveillance applications. The signals are aligned based on an online dynamic time warping approach that uses only video content information. The algorithm was tested in the alignment of reference and target videos acquired in a cluttered industrial environment with a moving camera. During each recording, the camera follows approximately the same trajectory but its speed along the trajectory may differ among recordings, thus generating time warping between the videos. The results shows that, when considering both alignment error and computational complexity, the use of the mean squared error as similarity metric leads to the best performance among metrics such as the SSIM, absolute error or even sophisticated matching techniques such as histograms of oriented gradients. The proposed method was also tested in a real-time application. Results show that the instantaneous alignment computation of a target frame can be performed successfully, at the cost of a three-fold increase in the error when compared to the case when latency is allowed.
Environmental Toxin Biliatresone-Induced Biliary Atresia-like Abnormal Cilia and Bile Duct Cell Development of Human Liver Organoids

Biliary atresia (BA) is a poorly understood and devastating obstructive bile duct disease of newborns. Biliatresone, a plant toxin, causes BA-like syndrome in some animals, but its relevance in humans is unknown. To validate the hypothesis that biliatresone exposure is a plausible BA disease mechanism in humans, we treated normal human liver organoids with biliatresone and addressed its adverse effects on organoid development, functions and cellular organization. The control organoids (without biliatresone) were well expanded and much bigger than biliatresone-treated organoids. Expression of the cholangiocyte marker CK19 was reduced, while the hepatocyte marker HFN4A was significantly elevated in biliatresone-treated organoids. ZO-1 (a tight junction marker) immunoreactivity was localized at the apical intercellular junctions in control organoids, while it was markedly reduced in biliatresone-treated organoids. Cytoskeleton F-actin was localized at the apical surface of the control organoids, but it was ectopically expressed at the apical and basal sides in biliatresone-treated organoids. Cholangiocytes of control organoids possess primary cilia and elicit cilia mechanosensory function. The number of ciliated cholangiocytes was reduced, and cilia mechanosensory function was hampered in biliatresone-treated organoids. In conclusion, biliatresone induces morphological and developmental changes in human liver organoids resembling those of our previously reported BA organoids, suggesting that environmental toxins could contribute to BA pathogenesis.
Diagnosis of weaknesses in modern error correction codes: a physics approach

One of the main obstacles to the wider use of the modern error-correction codes is that, due to the complex behavior of their decoding algorithms, no systematic method which would allow characterization of the bit-error-rate (BER) is known. This is especially true at the weak noise where many systems operate and where coding performance is difficult to estimate because of the diminishingly small number of errors. We show how the instanton method of physics allows one to solve the problem of BER analysis in the weak noise range by recasting it as a computationally tractable minimization problem.
TaxonGap: a visualization tool for intra- and inter-species variation among individual biomarkers

UNLABELLED Selection of optimal biomarkers for the identification of different operational taxonomic units (OTUs) may be a hard and tedious task, especially when phylogenetic trees for multiple genes need to be compared. With TaxonGap we present a novel and easy-to-handle software tool that allows visual comparison of the discriminative power of multiple biomarkers for a set of OTUs. The compact graphical output allows for easy comparison and selection of individual biomarkers. AVAILABILITY Graphical User Interface; Executable JAVA archive file, source code, supplementary information and sample files can be downloaded from the website: http://www.kermit. ugent.be/taxongap
Comparative evaluation of low-level laser and systemic steroid therapy in adjuvant-enhanced arthritis of rat temporomandibular joint: A histological study

Background: Low-level laser therapy (LLLT) has shown a promising effect in ameliorating symptoms of rheumatoid arthritis (RA). The aim of this investigation was to compare the early and late anti-inflammatory effects of LLLT and betamethasone in RA. Materials and Methods: In this animal experimental study, after inducing a model of RA in temporomandibular joint (TMJ) of 37 Wistar rats using adjuvant injection, they were randomly distributed into three experimental groups of 12 animals each: (1) LLLT group; (2) steroid group which received a single dose of betamethasone systemically; and (3) positive control group, which did not receive any treatment. One rat served as the negative control. Half of the animals in all the experimental groups were sacrificed on the 21st day after RA induction (early phase), and the other half were sacrificed 2 weeks later (late phase). Then, the severity of TMJ inflammation was assessed histologically in each group on a semi-quantitative scale. Kruskal-Wallis and Mann-Whitney tests were used to compare differences (α = 0.05). Results: The LLLT and steroid groups showed significantly (P < 0.05) lower inflammation mean scores in both early (5.66 [±1.86] and 1.66 [±1.21], respectively) and late phases of evaluation (1.16 [±1.47] and 6.50 [±1.04], respectively) compared to positive control group in early and late stages of assessment (11.66 [±3.50] and 8.66 [±1.36], respectively). However, the best results (P < 0.005) were achieved in early phase of the steroid group as well as late phase of the LLLT group. Conclusion: Within limitations of this study, it may be concluded that LLLT method has a long-term promising effect on reducing inflammation severity of TMJ similar to betamethasone in earlier stages.
Boosting the Accuracy of Multispectral Image Pansharpening by Learning a Deep Residual Network

In the field of multispectral (MS) and panchromatic image fusion (pansharpening), the impressive effectiveness of deep neural networks has recently been employed to overcome the drawbacks of the traditional linear models and boost the fusion accuracy. However, the existing methods are mainly based on simple and flat networks with relatively shallow architectures, which severely limits their performance. In this letter, the concept of residual learning is introduced to form a very deep convolutional neural network to make the full use of the high nonlinearity of the deep learning models. Through both quantitative and visual assessments on a large number of high-quality MS images from various sources, it is confirmed that the proposed model is superior to all the mainstream algorithms included in the comparison, and achieves the highest spatial–spectral unified accuracy.
Relieving Core Routers from Dynamic Routing with off-the-shelf Equipment and Protocols

To answer traffic engineering goals, current backbone networks use expensive and sophisticated equipments, that run distributed algorithms to imple- ment dynamic multi-path routing (e.g., MPLS tunnels and dynamic trunk rerout- ing). We think that the same goals can be fulfilled using a simpler approach, where the core of the backbone only implements many a priori computed paths, and most adaptation to traffic engineering goals only takes place at the edge of the network. In the vein of Software Defined Networking, edge adaptation should be driven by a logically centralized controller that leverages the available paths to adapt traffic load balancing to the current demands and network status. In this article we present two algorithms to help building this vision. The first one selects sets of paths able to support future load balancing needs and adaptation to network faults. As the total number of required paths is very important, and their continuous availability requires many FIB entries in core routers, we also present a second algorithm that aggregates these paths in a reduced number of trees. This second algorithm achieves better results than previously proposed algorithms for path aggregation. To conclude, we show that off-the-shelf equipment supporting simple protocols may be used to implement routing with these trees, what shows that simplicity in the core can be achieved by using only trivially available proto- cols and their most common and unsophisticated implementation
Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin's lymphoma.

BACKGROUND Immunotoxins (ITs) consist of cell binding ligands coupled to toxins or their subunits. Hodgkin's lymphoma (HL) is an excellent target for ITs since lymphocyte activation markers such as CD25 and CD30 are expressed in large numbers. The ITs RFT5.dgA (anti CD25) and Ki-4.dgA (anti CD30) were constructed by linking the monoclonal antibodies RFT5 and Ki-4 to deglycosylated ricin A-chain (dgA). Both ITs showed potent specific activity against HL cells in vitro and in vivo in animal models, and were subsequently evaluated in phase I/II clinical trials in humans. PATIENTS AND METHODS In two separate trials, the ITs were administered i.v. four times every other day over 4 h. The objectives of the phase I trials included the determination of the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), pharmacokinetics, antitumor activity and immune response against the IT. RESULTS Twenty-seven patients with refractory HL were included in the phase I/II study of RFT5.dgA and 17 patients were included in the phase I study of Ki-4.dgA. The MTD of RFT5.dgA was 15 mg/m(2), whereas that of Ki-4.dgA was 5 mg/m(2). DLTs were related to vascular leak syndrome, consisting of edema, tachycardia, dyspnea, weakness and myalgia. Measurement of serum levels of RFT5.dgA demonstrated a C(max) of 0.2-9.7 micro g/ml with a half-life (t()) varying from 4 to 10.5 h. Peak serum concentration of Ki-4.dgA ranged from 0.23 to 1.7 micro g/ml. In both trials approximately 60% of patients developed human anti-mouse and/or anti-dgA antibodies. Seventeen of 18 patients treated at the MTD of RFT5.dgA were evaluable for clinical response. Responses included two partial remissions (PR), one minor response (MR) and five stable diseases (SD). Fifteen of 17 patients treated with Ki-4.dgA were evaluable for clinical response. Responses included one PR, one MR and two SD. CONCLUSIONS RFT5.dgA and Ki-4.dgA showed moderate efficacy in heavily pretreated refractory patients with HL. Ki-4.dgA was less well tolerated than RFT5.dgA. This might be due, at least in part, to the formation of Ki-4.dgA/sCD30 complexes.
On the origin of the absorption features in SS 433

We present high-resolution optical spectroscopy of the X-ray binary system SS 433, obtained over a wide range of orbital phases. The spectra display numerous weak absorption features, and include the clearest example seen to date of those features (resembling a mid-A type supergiant spectrum), which have previously been associated with the mass-donor star. However, the new data preclude the hypothesis that these features originate solely within the photosphere of the putative mass donor, indicating that there may be more than one region within the system producing an A supergiant-like spectrum, probably an accretion disc wind. Indeed, whilst we cannot confirm the possibility that the companion star is visible at certain phase combinations, it is possible that all supergiant-like features observed thus far are produced solely in a wind. We conclude that great care must be taken when interpreting the behaviour of these weak features.
Carcinoembryonic antigen and blood group substances.

Immunochemical studies support the view that carcinoembryonic antigens from entodermally derived adenocarcinomata are incomplete blood group substances of the ABO system. The deficient antigens have a tumor-specific activity, due to unmasking of a structural sequence that is cryptic in the normal situation. Two other serological activities of the tumor antigens are determined by N -acetylgalactosaminyl peptide and antigenic Complex I sequences identical to those found in blood group substances. The structural results imply that the genetic changes in oncogenesis include deletion or repression of the gene(s) controlling the transferase(s) for the terminal sequences of classical ABO-active glycoproteins. The development of specific serodiagnostic tests for tumors of entodermal origin will probably depend on the production of sera with high activity for the tumor-specific determinant and little or no activity for the normal blood group sequences also found in carcinoembryonic antigen.
Embedding laws in diffusions by functions of time

We present a constructive probabilistic proof of the fact that if B=(Bt)t≥0 is standard Brownian motion started at 0, and μ is a given probability measure on R such that μ({0})=0, then there exists a unique left-continuous increasing function b:(0,∞)→R∪{+∞} and a unique left-continuous decreasing function c:(0,∞)→R∪{−∞} such that B stopped at τb,c=inf{t>0|Bt≥b(t) or Bt≤c(t)} has the law μ. The method of proof relies upon weak convergence arguments arising from Helly’s selection theorem and makes use of the Levy metric which appears to be novel in the context of embedding theorems. We show that τb,c is minimal in the sense of Monroe so that the stopped process Bτb,c=(Bt∧τb,c)t≥0 satisfies natural uniform integrability conditions expressed in terms of μ. We also show that τb,c has the smallest truncated expectation among all stopping times that embed μ into B. The main results extend from standard Brownian motion to all recurrent diffusion processes on the real line.
Capacity analysis of multibeam joint decoding over composite satellite channels

The throughput of current multibeam satellite systems is limited by self interference. Interference mitigation techniques have the potential to significantly increase the spectral efficiency of these satellite communication systems. The present contribution investigates the ergodic capacity of the return link of a multibeam satellite system, where full frequency reuse is employed and user signals are jointly processed at the gateway. The proposed model incorporates correlated satellite antennas over Rician channels which represent some inherent characteristics of satellite communications. Additionally, the effects of shadowing caused by user mobility, are modeled via the lognormal distribution. Hence, a composite Rician/lognormal fading channel with fully correlated receive antennas is considered. For this channel, a new lower bound on the ergodic capacity is analytically deduced and verified through simulations.
Intravenous glial‐derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter

Rats with experimental Parkinson's disease (PD) are treated with intravenous glial‐derived neurotrophic factor (GDNF) plasmid DNA, non‐viral gene therapy using Trojan horse liposomes (THLs) targeted with a monoclonal antibody (MAb) to the rat transferrin receptor (TfR). Expression of the transgene is confined to catecholaminergic cells by placement of the GDNF gene under the influence of the rat tyrosine hydroxylase (TH) promoter.
The price of certainty: "waterslide curves" and the gap to capacity

The classical problem of reliable point-to-point digital communication is to achieve a low probability of error while keeping the rate high and the total power consumption small. Traditional information-theoretic analysis uses `waterfall' curves to convey the revolutionary idea that unboundedly low probabilities of bit-error are attainable using only finite transmit power. However, practitioners have long observed that the decoder complexity, and hence the total power consumption, goes up when attempting to use sophisticated codes that operate close to the waterfall curve. This paper gives an explicit model for power consumption at an idealized decoder that allows for extreme parallelism in implementation. The decoder architecture is in the spirit of message passing and iterative decoding for sparse-graph codes. Generalized sphere-packing arguments are used to derive lower bounds on the decoding power needed for any possible code given only the gap from the Shannon limit and the desired probability of error. As the gap goes to zero, the energy per bit spent in decoding is shown to go to infinity. This suggests that to optimize total power, the transmitter should operate at a power that is strictly above the minimum demanded by the Shannon capacity. The lower bound is plotted to show an unavoidable tradeoff between the average bit-error probability and the total power used in transmission and decoding. In the spirit of conventional waterfall curves, we call these `waterslide' curves.
Mild parkinsonism in persons exposed to 1‐methyl‐4‐phenyl‐1,2,3,6‐ tetrahydropyridine (MPTP)

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) produces moderate to severe parkinsonism in humans, but has not been reported to cause a syndrome similar to early Parkinson's disease. We now report 22 cases of mild parkinsonism resulting from exposure to MPTP.
Better Guarantees for Sparsest Cut Clustering

The field of approximation algorithms for clustering is a very active one and a large number of algorithms have been developed for clustering objectives such as k-median, min-sum, and sparsest cut clustering. For most of these objectives, the approximation guarantees do not match the known hardness results, and much effort is spent on obtaining tighter approximation guarantees [1, 4, 5, 8, 6, 9, 10]. However, for many practical clustering problems such as clustering proteins by function, or clustering images by subject, there is some unknown correct “target” clustering; in such cases the pairwise information is merely based on some heuristics and the real goal is to achieve low error on the data. In these settings, the implicit hope is that approximately optimizing objective functions such as those mentioned above will in fact produce a clustering of low error, i.e., a clustering that is close pointwise to the truth. Formally, for a set of n data points the error of a clustering the error of a clustering C′ = {C ′ 1, . , C ′ k} with respect to target clustering C = {C1, . , Ck} is the fraction of points on which C and C′ disagree under the optimal matching of clusters in C to clusters in C′, i.e.