Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk Factors Associated with Colorectal Cancer in a Subset of Patients with Mutations in MLH1 and MSH2 in Taiwan Fulfilling the Amsterdam II Criteria for Lynch Syndrome

Background and Aim Lynch syndrome, caused by germline mutations in mismatch repair genes, is a predisposing factor for colorectal cancer (CRC). This retrospective cohort study investigated the risk factors associated with the development of CRC in patients with MLH1 and MSH2 germline mutations. Methods In total, 301 MLH1 and MSH2 germline mutation carriers were identified from the Amsterdam criteria family registry provided by the Taiwan Hereditary Nonpolyposis Colorectal Cancer Consortium. A Cox proportional hazard model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the association between the risk factors and CRC development. A robust sandwich covariance estimation model was used to evaluate family dependence. Results Among the total cohort, subjects of the Hakka ethnicity exhibited an increased CRC risk (HR = 1.62, 95% CI = 1.09–2.34); however, those who performed regular physical activity exhibited a decreased CRC risk (HR = 0.62, 95% CI = 0.41–0.88). The CRC risk was enhanced in MLH1 germline mutation carriers, with corresponding HRs of 1.72 (95% CI = 1.16–2.55) and 0.54 (95% CI = 0.34–0.83) among subjects of the Hakka ethnicity and those who performed regular physical activity, respectively. In addition, the total cohort with a manual occupation had a 1.56 times higher CRC risk (95% CI = 1.07–2.27) than did that with a skilled occupation. Moreover, MSH2 germline mutation carriers with blood group type B exhibited an increased risk of CRC development (HR = 2.64, 95% CI = 1.06–6.58) compared with those with blood group type O. Conclusion The present study revealed that Hakka ethnicity, manual occupation, and blood group type B were associated with an increased CRC risk, whereas regular physical activity was associated with a decreased CRC risk in MLH1 and MSH2 germline mutation carriers.
EVIDENCE FOR THE EXPANDING ROLE OF CONSULTATION IN THE PRACTICE OF SCHOOL PSYCHOLOGISTS

In 2010, the National Association of School Psychologists approved the Model for Comprehensive and Integrated School Psychological Services (or the NASP Practice Model), codifying what an expanded role encompasses in the delivery of school-based psychological services. This study examined the role and function of school psychology practitioners from three Midwestern states with different legal statues and policy initiatives related to the practice of school psychology. A total of 175 practicing school psychologists from Missouri, Illinois, and Iowa reported their actual and preferred practices and completed a self-assessment on their knowledge of the NASP Practice Model. Results showed participants not only identified problem-solving consultation as their most knowledgeable domain of practice but also the activity on which they spent the greatest amount of their time. Analysis by state revealed differential levels of practice devoted to consultation and intervention. Study findings are discussed relative to the potential impact and importance of state law and policy initiatives.
STEM High Schools Teachers’ Belief Regarding STEM Student Giftedness

Teachers’ beliefs about students influence many of the decisions they make in the classroom. While much work has been done exploring teachers’ beliefs as they relate to the nomination of students for gifted programs, little work has yet explored the ways in which teachers’ beliefs about student giftedness possibly affect instructional decisions. In this article, within the context of specialized STEM schools, the beliefs of teachers as related to their students’ giftedness and ability are explored. Findings indicated that teachers believe their students to be gifted regardless of designation. Teachers articulated beliefs around the type of learning opportunities gifted students need as well as the amount of work required to stimulate these students. Specifically, teachers stated that gifted students flourish under heavy workloads with intense amounts of independent and inquiry-based learning. Students were also queried to determine their own perceptions of these instructional practices on their learning and daily lives.
A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis

Human DNA polymerase mu (Polμ) is a family X member that has terminal transferase activity but, in spite of a non-orthodox selection of the template information, displays its maximal catalytic efficiency in DNA-templated reactions. As terminal deoxynucleotidyl transferase (TdT), Polμ has a specific loop (loop1) that could provide this enzyme with its terminal transferase activity. When loop1 was deleted, human Polμ lacked TdT activity but improved DNA-binding and DNA template-dependent polymerization. Interestingly, when loop1 from TdT was inserted in Polμ (substituting its cognate loop1), the resulting chimaera displayed TdT activity, preferentially inserting dGTP residues, but had a strongly reduced template-dependent polymerization activity. Therefore, a specialized loop in Polμ, that could adopt alternative conformations, appears to provide this enzyme with a dual capacity: (i) template independency to create new DNA information, in which loop1 would have an active role by acting as a ‘pseudotemplate’; (ii) template-dependent polymerization, in which loop1 must allow binding of the template strand. Recent in vivo and in vitro data suggest that such a dual capacity could be advantageous to resolve microhomology-mediated end-joining reactions.
The loss of histone H3 lysine 9 acetylation due to dSAGA-specific dAda2b mutation influences the expression of only a small subset of genes

In Drosophila, the dADA2b-containing dSAGA complex is involved in histone H3 lysine 9 and 14 acetylation. Curiously, although the lysine 9- and 14-acetylated histone H3 levels are drastically reduced in dAda2b mutants, these animals survive until a late developmental stage. To study the molecular consequences of the loss of histone H3 lysine 9 and 14 acetylation, we compared the total messenger ribonucleic acid (mRNA) profiles of wild type and dAda2b mutant animals at two developmental stages. Global gene expression profiling indicates that the loss of dSAGA-specific H3 lysine 9 and 14 acetylation results in the expression change (up- or down-regulation) of a rather small subset of genes and does not cause a general transcription de-regulation. Among the genes up-regulated in dAda2b mutants, particularly high numbers are those which play roles in antimicrobial defense mechanisms. Results of chromatin immunoprecipitation experiments indicate that in dAda2b mutants, the lysine 9-acetylated histone H3 levels are decreased both at dSAGA up- and down-regulated genes. In contrast to that, in the promoters of dSAGA-independent ribosomal protein genes a high level of histone H3K9ac is maintained in dAda2b mutants. Our data suggest that by acetylating H3 at lysine 9, dSAGA modifies Pol II accessibility to specific promoters differently.
The contribution of the central executive to visuo-spatial bootstrapping in younger adults, older adults and patients with mild cognitive impairment

Background. Recent studies on verbal immediate serial recall (Darling & Havelka, 2010; Darling et al., 2012, 2014; Allen et al., 2015) show evidence of the integration of information from verbal and visuo-spatial short term memory with long-term memory representations. This so-called ‗visuo-spatial bootstrapping‘ (VSB) pattern, in which verbal serial recall is improved when the information is arranged in a familiar spatially distributed pattern, such as a telephone keypad, is consistent with the existence within working memory of an episodic buffer. Objective. The general purpose was to investigate the structure of working memory, and in particular the relationship between verbal and visuo-spatial working memory. Specifically, this thesis aimed to determine the contribution of the central executive and the implications of the VSB paradigm in younger and older adults and patients with Mild Cognitive Impairment (MCI). Materials and Methods. The first study explored the role of the central executive. The VSB task with digit sequences, visually presented both in single and in a typical keypad display, was administered under conditions of verbal and central executive load. In the second study VSB was investigated in older and younger adults using three conditions: single digit display, typical and random keypad. In the third study, examining performance in VSB in a typical elderly sample compared with people with MCI. Each participant was assessed with a neuropsychological battery of tests and the VSB task composed by single digit and typical keypad display. Results and Conclusion. Central executive load demonstrated to have a negative effect on digit recall performance without affecting the bootstrapping effect. VSB does not need to recruit executive resources. No difference was observed in the bootstrapping pattern as a consequence of age and cognitive difficulties and the beneficial impact of additional visual information was comparable for MCI, older and younger participants.
Short-term forgetting in sentence comprehension: Crosslinguistic evidence from verb-final structures

Seven experiments using self-paced reading and eyetracking suggest that omitting the middle verb in a double centre embedding leads to easier processing in English but leads to greater difficulty in German. One commonly accepted explanation for the English pattern—based on data from offline acceptability ratings and due to Gibson and Thomas (1999)—is that working-memory overload leads the comprehender to forget the prediction of the upcoming verb phrase (VP), which reduces working-memory load. We show that this VP-forgetting hypothesis does an excellent job of explaining the English data, but cannot account for the German results. We argue that the English and German results can be explained by the parser's adaptation to the grammatical properties of the languages; in contrast to English, German subordinate clauses always have the verb in clause-final position, and this property of German may lead the German parser to maintain predictions of upcoming VPs more robustly compared to English. The evidence thus argues against language-independent forgetting effects in online sentence processing; working-memory constraints can be conditioned by countervailing influences deriving from grammatical properties of the language under study.
It All Starts Now! Gay Men and Fatherhood in Sweden

ABSTRACT This article investigates how Swedish gay men pursue and understand fatherhood, using a qualitative, semi-structured methodological approach. We are interested in how practical issues and different fatherhood arrangements are understood and handled by the fathers; how the construction of “rainbow families” is understood in relation to legal issues; parental responsibilities; and thoughts regarding gender-equal and gender-neutral relationships within Swedish society and culture. The results show that the trajectory of gay men toward fatherhood is shaped by a variety of mediating factors such as interactions with agencies, clinics, attorneys, and the state. There are some significant legal, social, financial, and cultural obstacles to realizing gay parenthood. There are also cases where study participants talked about a sense of intolerance expressed toward gay parents within a gay community. Although there are still strong normative dimensions involved in the construction of modern parenthood, the grip of heteronormative views on family life and sexuality is changing; the narratives presented also represent a questioning of the hegemonic image of fatherhood in Sweden. Consequently, it is possible to discern different attempts at transgressing and changing the cultural landscape of fatherhood and the ways people build families today.
Safety Assessment and Control of Robotic Manipulators Using Danger Field

This paper presents a synergistic approach to danger assessment and safety-oriented control of articulated robots that are based on a quantity called danger field. This quantity captures the state of the robot as a whole and indicates how dangerous the current posture and velocity of the robot are to the objects in the environment. The field itself is invariant with respect to objects around the robot and can be computed in any given point of the robot's workspace using measurements from the proprioceptive sensors. Furthermore, the danger field can be expressed in the closed form, which enables its fast computation. Apart from being a pure safety assessment, the danger field provides a natural prelude to safety-oriented control strategy. Namely, the information about the danger field can easily be fed back to shape standard control schemes in order to make the motion of the robot safer to the environment. The proposed method is validated through simulations and experiments.
Charge equilibration for molecular dynamics simulations

We report here an approach for predicting charge distributions in molecules for use in molecular dynamics simulations. The input data are experimental atomic ionization potentials, electron affinities, and atomic radii. An atomic chemical potential is constructed by using these quantities plus shielded electrostatic interactions between all charges. Requiring equal chemical potentials leads to equilibrium charges that depend upon geometry. This charge equilibration (QEq) approach leads to charges in excellent agreement with experimental dipole moments and with the atomic charges obtained from the electrostatic potentials of accurate ab initio calculations. QEq can be used to predict charges for any polymer, ceramic, semiconductor, or biological system, allowing extension of molecular dynamics studies to broad classes of new systems. The charges depend upon environment and change during molecular dynamics calculations. We indicate how this approach can also be used to predict infrared intensities, dielectric constants, and other charge-related properties.
Relationship between anthropometric, physiological and physical characteristics with success of female taekwondo athletes

The aim of this study was to investigate the relationship between anthropometric, physiological and physical characteristics with success of elite female taekwondo athletes. Forty subjects were selected from elite female taekwondo athletes who won medals in regional and national championships. Individual information forms were completed. The mean age, height and body mass index of subjects were 17.84±3.67 years, 167.56±6.92 cm and 19.12±2.45 kg/m 2 respectively. All subjects were assessed for height, weight, lengths, girths, body mass index, waist-to-hip ratio and skin-fold thickness. Percentage of body fat was calculated from the sum of 3 site measurements of skin-fold thickness. Aerobic and anaerobic power were also calculated using by cooper and Sargent vertical jump tests respectively and then by placing into the standard recommended equations. Speed, agility, muscular endurance and flexibility were assessed using by 36m sprint, 4×9m shuttle run, push-ups and sit-and-reach tests respectively. From all of anthropometric, physiological and physical characteristics, anaerobic and aerobic power, body mass index and fat percentage, speed and agility were significantly related to success and had more importance for taekwondo athletes. Thus, these characteristics have a major effect on taekwondo specially, in championship goals and should be considered in talent identification and training planning of this sport.
Needs and Values: An Exploration

Maslow contended that different needs are associated with different values. Therefore, the objective of the present study was to identify the values that are correlated with each of the needs in Maslow’s hierarchy using an Indian sample of young adults. The Deficiency-Need Preoccupation Checklist, a measure of preoccupation with each of the deficiency-needs (d-needs), was developed for the purpose of the present study. Participants (N = 200) completed 4 assessments: the Deficiency-Need Preoccupation Checklist, Satisfaction with Life Scale, Short Index of Self-Actualization, and Portrait of Values Questionnaire–Revised. We found support for a 4-factor structure of d-need preoccupation, in accordance with Maslow’s hierarchy. Furthermore, d-need preoccupation correlated negatively with self-actualization; the magnitude of the coefficient between d-need preoccupation and self-actualization strengthened as the theoretical proximity between the need and self-actualization increased. In addition, the values that correlated positively with d-needs and negatively with self-actualization belonged to the value clusters “self-enhancement” and “conservation”; conversely, the values that correlated negatively with d-needs and positively with self-actualization belonged to the value clusters “self-transcendence” and “openness to change. ”
Effect of Time Window on the Performance of Continuous Regression Testing

Test prioritization is an effective technique used to reduce the amount of work required to support regression testing in continuous integration development. It aims at finding an optimal order of tests that can detect regressions faster, potentially increasing the frequency of software releases. Prioritization techniques based on test execution history use the results of preceding executions to determine an optimal order of regression tests in the succeeding test executions. In this paper, we investigate how can execution history be optimally used to increase the effectiveness of regression test prioritization. We analyze the effect of history time window on the fault detection effectiveness of prioritized regression tests. We report an experimental study using a data set from Cisco. The results suggest that varying the size of the window can considerably change the performance of regression testing. Our findings will potentially help developers and test teams in adjusting test prioritization techniques for achieving higher cost-effectiveness in continuous regression testing.
Improved Algorithm for Learning of Genetic Regulatory Network Connectivity from Time Series Data

Solid inorganic polymers are derivatives of phosphorous or phosphonic acids which contain cyclic organo groups selected from the group consisting of alicyclics, aromatics and heterocyclics. They are characterized by the structural linkage of three oxygens bonded to phosphorus to one or more tetravalent metals selected from the group consisting of titanium, zirconium, cerium, hafnium, lead, thorium and uranium. The molar ratio of phosphorus to tetravalent metal is about 2 to 1. One use for the polymers is as stationary phases or supports in chromatography.
SPIDER DENSITY AND DIVERSITY IN RELATION TO DISTURBANCE IN AGROECOSYSTEMS IN NEW ZEALAND, WITH A COMPARISON TO ENGLAND

increased with decreasing frequency and/or intensity of disturbance from two species and 1.8 individuals m -2 in wheat to 16 species and 130 indiv. m -2 in an abandoned, ungrazed pasture. The spider fauna was dominated by introduced species of money spiders (Linyphiidae). The most abundant species, Lepthyphantes tenuis, is also the most abundant one in British cultivated habitats. Additional pitfall trap samples from the same location and the Waikato, central North Island, indicated a similar species range containing mainly European species. A sample from a native tussock habitat had a completely different fauna, with only one species shared with the most undisturbed cultivated area. Comparative samples showed that similarly structured, but about twice as species-rich assemblages live in similar cultivated habitats in England.
More reliable inference for the dissimilarity index of segregation

Summary The most widely used measure of segregation is the so‐called dissimilarity index. It is now well understood that this measure also reflects randomness in the allocation of individuals to units (i.e. it measures deviations from evenness, not deviations from randomness). This leads to potentially large values of the segregation index when unit sizes and/or minority proportions are small, even if there is no underlying systematic segregation. Our response to this is to produce adjustments to the index, based on an underlying statistical model. We specify the assignment problem in a very general way, with differences in conditional assignment probabilities underlying the resulting segregation. From this, we derive a likelihood ratio test for the presence of any systematic segregation, and bias adjustments to the dissimilarity index. We further develop the asymptotic distribution theory for testing hypotheses concerning the magnitude of the segregation index and show that the use of bootstrap methods can improve the size and power properties of test procedures considerably. We illustrate these methods by comparing dissimilarity indices across school districts in England to measure social segregation.
Event and Temporal Expression Extraction from Raw Text: First Step towards a Temporally Aware System

Extracting temporal information from raw text is fundamental for deep language understanding, and key to many applications like question answering, information extraction, and document summarization. Our long-term goal is to build complete temporal structure of documents and use the temporal structure in other applications like textual entailment, question answering, visualization, or others. In this paper, we present a first step, a system for extracting events, event features, main events, temporal expressions and their normalized values from raw text. Our system is a combination of deep semantic parsing with extraction rules, Markov Logic Network classifiers and Conditional Random Field classifiers. To compare with existing systems, we evaluated our system on the TempEval-1 and TempEval-2 corpus. Our system outperforms or performs competitively with existing systems that evaluate on the TimeBank, TempEval-1 and TempEval-2 corpus and our performance is very close to inter-annotator agreement of the TimeBank annotators.
Grandiose and Vulnerable Narcissism and the DSM–5 Pathological Personality Trait Model

The Diagnostic and Statistical Manual of Personality Disorders (4th ed., American Psychiatric Association, 2000) personality disorders (PDs) that will be included in the DSM–5 will be diagnosed in an entirely different manner; the explicit criterion sets will be replaced with impairments in self and interpersonal functioning and personality traits from a 25-trait dimensional model of personality pathology. From a trait perspective, narcissistic personality disorder (NPD), the focus of this study, is assessed using 2 specific traits: grandiosity and attention seeking. Using a sample collected online from Amazon's Mechanical Turk (MTurk; N = 306), we examined the relations among traits from a new measure of DSM–5's trait model—the Personality Inventory for DSM–5 (PID5; Krueger, Derringer, Markon, Watson, & Skodol, in press)—and grandiose and vulnerable narcissism. The 25 traits from PID5 captured a significant portion of the variance in grandiose and vulnerable factors, although the 2 specific facets designated for the assessment of NPD fared substantially better in the assessment of grandiose rather than vulnerable narcissism. These results are discussed in the context of improving the DSM–5's ability to capture both narcissism dimensions.