Miracle-dz/UniFAR-FTUs huggingface dataset:
Pension Risk, Retirement Saving and Insurance

Using a representative sample of Italian investors, we estimate the risk associated with pension benefits by eliciting for each individual the subjective distribution of the replacement rate as a summary indicator of social security wealth. We find substantial heterogeneity of pension risk and show that it is consistently related to observable features in the pension system that have different effects on individuals with different characteristics. We then relate subjective pension risk to individuals’ financial decisions. We find that people try to attenuate the adverse consequences of pension wealth uncertainty by increasing demand for targeted retirement saving and for insurance. Individuals facing more pension wealth risk tend to enroll more often in private pension funds, invest more in life insurance and buy more private health insurance. These effects are consistent with people becoming more risk-averse when pension wealth becomes less predictable, leading them to search for greater financial security.
Investigation of Salivary Function and Oral Microbiota of Radiation Caries-Free People with Nasopharyngeal Carcinoma

Radiation caries have been reported to be correlated with radiotherapy-induced destruction of salivary function and changes in oral microbiota. There have been no published reports detailing patients who have remained radiation caries-free following radiotherapy for nasopharyngeal carcinoma. The aim of this study was to investigate the relationship between salivary function, oral microbiota and the absence of radiation caries. Twelve radiation caries-free patients and nine patients exhibiting radiation caries following irradiated nasopharyngeal carcinoma were selected. V40, the dose at which the volume of the contralateral parotid gland receives more than 40 Gy, was recorded. Stimulated saliva flow rate, pH values and buffering capacity were examined to assess salivary function. Stimulated saliva was used for molecular profiling by Denaturing Gradient Gel Electrophoresis. Mutans streptococci and Lactobacilli in saliva were also cultivated. There were no significant differences in V40 between radiation caries-free individuals and those with radiation caries. Compared with normal values, the radiation caries-free group had significantly decreased simulated saliva flow rate, while there were no significant differences in the saliva pH value and buffering capacity. Similar results were observed in the radiation caries group. There was no statistical difference in microbial diversity, composition and log CFU counts in cultivation from the radiation caries-free group and the radiation caries group. Eleven genera were detected in these two groups, among which Streptococcus spp. and Neisseria spp. had the highest distribution. Our results suggest that changes in salivary function and in salivary microbiota do not explain the absence of radiation caries in radiation caries-free individuals.
Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid

ABSTRACT Cytotoxic T lymphocytes (CTL) can trigger an apoptotic signal through the Fas receptor or by the exocytosis of granzyme B and perforin. Caspase activation is an important component of both pathways. Granzyme B, a serine proteinase contained in granules, has been shown to proteolytically process and activate members of the caspase family in vitro. In order to gain an understanding of the contributions of caspases 8 and 3 during granule-induced apoptosis in intact cells, we have used target cells that either stably express the rabbitpox virus-encoded caspase inhibitor SPI-2 or are devoid of caspase 3. The overexpression of SPI-2 in target cells significantly inhibited DNA fragmentation, phosphatidylserine externalization, and mitochondrial disruption during Fas-mediated cell death. In contrast, SPI-2 expression in target cells provided no protection against granzyme-mediated apoptosis, mitochondrial collapse, or cytolysis, leading us to conclude that SPI-2-inhibited caspases are not an essential requirement for the granzyme pathway. Caspase 3-deficient MCF-7 cells were found to be resistant to CTL-mediated DNA fragmentation but not to CTL-mediated cytolysis and loss of the mitochondrial inner membrane potential. Furthermore, we demonstrate that granzyme B directly cleaves the proapoptotic molecule Bid, bypassing the need for caspase 8 activation of Bid. These results provide evidence for a two-pronged strategy for mediating target cell destruction and provide evidence of a direct link between granzyme B activity, Bid cleavage, and caspase 3 activation in whole cells.
Origin of quasar progenitors from the collapse of low spin cosmological perturbations

We show that seeds for quasar black holes could have originated from the initial cosmological collapse of overdense regions with unusually small rotation. The gas in these rare regions collapses into a compact disk that shrinks on a short viscous time scale. Using an analytical model, we calculate the low-spin tail of the probability distribution of angular momenta for objects that collapse out of a Gaussian random field of initial density perturbations. The population of low-spin systems is significant for any viable power spectrum of primordial density perturbations. Most objects form just above the cosmological Jeans mass (\sim 10^5 M_sun) at high redshifts z>10. In the standard cold dark matter cosmology, the comoving density of 10^{6-7} M_sun objects with viscous evolution times shorter than 10^{6-7} years is about 10^{-3} (h/0.5)^3 Mpc^{-3}, comparable to the local density of bright galaxies. The seed black holes tend to reside within larger mass systems that collapse later and supply the gas needed for the bright quasar activity.
Interactive processing of contrastive expressions by Russian children

Children’s ability to interpret color adjective noun phrases (e.g., red butterfly) as contrastive was examined in an eyetracking study with 6-year-old Russian children. Pitch accent placement (on the adjective red, or on the noun butterfly) was compared within a visual context containing two red referents (a butterfly and a fox) when only one of them had a contrast member (a purple butterfly) or when both had a contrast member (a purple butterfly and a grey fox). Contrastiveness was enhanced by the Russian-specific ‘split constituent’ construction (e.g., Red put butterfly . . .) in which a contrastive interpretation of the color term requires pitch accent on the adjective, with the nonsplit sentences serving as control. Regardless of the experimental manipulations, children had to wait until hearing the noun (butterfly) to identify the referent, even in splits. This occurred even under conditions for which the prosody and the visual context allow adult listeners to infer the relevant contrast set and anticipate the referent prior to hearing the noun (accent on the adjective in 1-Contrast scenes). Pitch accent on the adjective did facilitate children’s referential processing, but only for the nonsplit constituents. Moreover, visual contexts that encouraged the correct contrast set (1-Contrast) only facilitated referential processing after hearing the noun, even in splits. Further analyses showed that children can anticipate the reference like adults but only when the contrast set is made salient by the preceding supportive discourse, that is, when the inference about the intended contrast set is provided by the preceding utterance.
International Capital Mobility and Crowding Out in the U.S. Economy: Imperfect Integration of Financial Markets or of Goods Markets?

Conventional wisdom in the field of international finance holds that the U.S. economy has become so open financiallly as to be characterized by perfect capital mobility: a highly elastic supply of foreign capital prevents the domestic rate of return from rising significantly above the world rate of return. This view has been challenged recently by the observation that investment rates are highly correlated with national saving rates, and the claim by Feldstein and Horioka that this correlation is evidence of relatively low capital mobility.The premise of this paper is that the Feldstein-Horioka finding regarding crowding out in an open economy is strong enough to survive the econometric critiques that have been leveled against it, but that it need have nothing to do with the degree of capital mobility in the sense of the openness of financial markets and the equalization of international interest rates expressed in a common currency. It is real interest rates that matter for questions of crowding out, and real interest parity requires not just that nominal interest rates be equalized expressed in a common currency, but also that purchasing power parity hold. It is well-known that purchasing power parity does not in fact hold. Currently, for example, the dollar is expected to depreciate in real terms. Thus real interest rate parity fails and crowding out takes place because of imperfect integration of goods markets, not imperfect integration of financial markets.
Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11

The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or promoter context. However, the detailed mechanisms by which it regulates the transcription of target genes such as ALDH1A1 remains to be elucidated. We therefore functionally assessed the ability of TLX1 to regulate ALDH1A1 expression in two hematopoietic cell lines, PER-117 T-leukemic cells and human erythroleukemic (HEL) cells, by use of luciferase reporter and mobility shift assays. We showed that TLX1 physically interacts with the general transcription factor TFIIB via its homeodomain, and identified two activities in respect to TLX1-mediated regulation of the CCAAT box-containing ALDH1A1 promoter. The first involved CCAAT-dependent transcriptional repression via perturbation of GATA factor-containing protein complexes assembled at a non-canonical TATA (GATA) box. A structurally intact homeodomain was essential for repression by TLX1 although direct DNA binding was not required. The second activity, which involved CCAAT-independent transcriptional activation did not require an intact homeodomain, indicating that the activation and repression functions of TLX1 are distinct. These findings confirm ALDH1A1 gene regulation by TLX1 and support an indirect model for TLX1 function, in which protein-protein interactions, rather than DNA binding at specific sites, are crucial for its transcriptional activity.
A Fast Satellite Selection Algorithm: Beyond Four Satellites

Satellite selection is an important executive logic to prevent unnecessary navigation signals in the first place for Global Positioning System (GPS) receivers with limited number of channels and real-time processing power, such as those used in mobile phones, cars, and space crafts. In this paper, we propose a fast satellite selection algorithm to select more than four satellites based on the optimal geometries, which can obtain the smallest geometric dilution of precision (GDOP) values. The main idea of this fast algorithm is to select a subset of all satellites in view whose geometry is the most similar to the optimal geometry. Computer simulation shows that the consumed time of this algorithm is very close to that of the quasi-optimal satellite selection algorithm and obviously lower than that of the traditional optimal satellite selection algorithm to minimize GDOP factor, but the increased GDOP values relative to the minimal GDOP values are much smaller than those of the quasi-optimal satellite selection algorithm.
Enhancing Sentiment Analysis of Financial News by Detecting Negation Scopes

Sentiment analysis refers to the extraction of the polarity of source materials, such as financial news. However, measuring positive tone requires the correct classification of sentences that are negated, i.e. The negation scopes. For example, around 4.74% of all sentences in German ad hoc announcements contain negations. To predict the corresponding negation scope, related literature commonly utilizes two approaches, namely, rule-based algorithms and machine learning. Nevertheless, a thorough comparison is missing, especially for the sentiment analysis of financial news. To close this gap, this paper uses German ad hoc announcements as a common example of financial news in order to pursue a two-sided evaluation. First, we compare the predictive performance using a manually-labeled dataset. Second, we examine how detecting negation scopes can improve the accuracy of sentiment analysis. In this instance, rule-based algorithms produce superior results, resulting in an improvement of up to 9.80% in the correlation between news sentiment and stock market returns.
Genetic causes of intellectual disability in a birth cohort: A population‐based study

Intellectual disability affects approximately 1–3% of the population and can be caused by genetic and environmental factors. Although many studies have investigated the etiology of intellectual disability in different populations, few studies have been performed in middle‐income countries. The present study estimated the prevalence of genetic causes related to intellectual disability in a cohort of children from a city in south Brazil who were followed from birth. Children who showed poor performance in development and intelligence tests at the ages of 2 and 4 were included. Out of 4,231 liveborns enrolled in the cohort, 214 children fulfilled the inclusion criteria. A diagnosis was established in approximately 90% of the children evaluated. Genetic causes were determined in 31 of the children and 19 cases remained unexplained even after extensive investigation. The overall prevalence of intellectual disability in this cohort due to genetic causes was 0.82%. Because this study was nested in a cohort, there were a large number of variables related to early childhood and the likelihood of information bias was minimized by collecting information with a short recall time. This study was not influenced by selection bias, allowing identification of intellectual disability and estimation of the prevalence of genetic causes in this population, thereby increasing the possibility of providing appropriate management and/or genetic counseling. © 2015 The Authors. American Journal of Medical Genetics Part A Published by Wiley Periodicals, Inc.
Discovery and Characterization of Transiting Super Earths Using an All-Sky Transit Survey and Follow-up by the James Webb Space Telescope

Doppler and transit surveys are finding extrasolar planets of ever smaller mass and radius, and are now sampling the domain of super Earths (1–3R⊕). Recent results from the Doppler surveys suggest that discovery of a transiting super Earth in the habitable zone of a lower main sequence star may be possible. We evaluate the prospects for an all-sky transit survey targeted to the brightest stars, that would find the most favorable cases for photometric and spectroscopic characterization using the James Webb Space Telescope (JWST). We use the proposed Transiting Exoplanet Survey Satellite (TESS) as representative of an all-sky survey. We couple the simulated TESS yield to a sensitivity model for the MIRI and NIRSpec instruments on JWST. Our sensitivity model includes all currently known and anticipated sources of random and systematic error for these instruments. We focus on the TESS planets with radii between those of Earth and Neptune. Our simulations consider secondary eclipse filter photometry using JWST/MIRI, comparing the 11 and 15 μm bands to measure CO2 absorption in super Earths, as well as JWST/NIRSpec spectroscopy of water absorption from 1.7–3.0 μm, and CO2 absorption at 4.3 μm. We find that JWST will be capable of characterizing dozens of TESS super Earths with temperatures above the habitable range, using both MIRI and NIRspec. We project that TESS will discover about eight nearby habitable transiting super Earths, all orbiting lower–main-sequence stars. The principal sources of uncertainty in the prospective JWST characterization of habitable super Earths are super-Earth frequency and the nature of super-Earth atmospheres. Based on our estimates of these uncertainties, we project that JWST will be able to measure the temperature and identify molecular absorptions (water, CO2) in one to four nearby habitable TESS super Earths orbiting lower–main-sequence stars.
Secure Nearest Neighbor Query on Crowd-Sensing Data

Nearest neighbor queries are fundamental in location-based services, and secure nearest neighbor queries mainly focus on how to securely and quickly retrieve the nearest neighbor in the outsourced cloud server. However, the previous big data system structure has changed because of the crowd-sensing data. On the one hand, sensing data terminals as the data owner are numerous and mistrustful, while, on the other hand, in most cases, the terminals find it difficult to finish many safety operation due to computation and storage capability constraints. In light of they Multi Owners and Multi Users (MOMU) situation in the crowd-sensing data cloud environment, this paper presents a secure nearest neighbor query scheme based on the proxy server architecture, which is constructed by protocols of secure two-party computation and secure Voronoi diagram algorithm. It not only preserves the data confidentiality and query privacy but also effectively resists the collusion between the cloud server and the data owners or users. Finally, extensive theoretical and experimental evaluations are presented to show that our proposed scheme achieves a superior balance between the security and query performance compared to other schemes.
Fundamental concepts in human communication

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Clinical Relevance of HLA Gene Variants in HBV Infection

Host gene variants may influence the natural history of hepatitis B virus (HBV) infection. The human leukocyte antigen (HLA) system, the major histocompatibility complex (MHC) in humans, is one of the most important host factors that are correlated with the clinical course of HBV infection. Genome-wide association studies (GWASs) have shown that single nucleotide polymorphisms (SNPs) near certain HLA gene loci are strongly associated with not only persistent HBV infection but also spontaneous HBV clearance and seroconversion, disease progression, and the development of liver cirrhosis and HBV-related hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB). These variations also influence the efficacy of interferon (IFN) and nucleot(s)ide analogue (NA) treatment and response to HBV vaccines. Meanwhile, discrepant conclusions were reached with different patient cohorts. It is therefore essential to identify the associations of specific HLA allele variants with disease progression and viral clearance in chronic HBV infection among different ethnic populations. A better understanding of HLA polymorphism relevance in HBV infection outcome would enable us to elucidate the roles of HLA SNPs in the pathogenesis and clearance of HBV in different areas and ethnic groups, to improve strategies for the prevention and treatment of chronic HBV infection.
The Role of Fiscal Transfers for Regional Economic Convergence in Europe

This paper provides evidence on the role of net fiscal transfers to households and EU structural funds for per-capita output convergence across a large sample of European regions during the period 1995-2005. We find that net fiscal transfers, while achieving regional redistribution, seem to impede output growth and promote an "immiserising convergence": output growth rates in poor receiving regions decline by less than in rich paying regions. EU structural and cohesion funds spent during 1994-1999 had a positive, but slight, impact on future economic growth, mainly through the human development component. JEL Classification: E62, R11, R23
The promise of diversity : over 40 voices discuss strategies for eliminating discrimination in organizations

All the talk, all the new laws, all the seminars on learning to live with each other's differences - and still the workplace remains a hostile environment for too many people. Many organizations are still in the grip of racism, sexism, and other forms of oppression, even after the Civil Rights Act, the Women's Movement, countless workshops, support groups, and organizational initiatives. Is it possible to truly eliminate discrimination? Why do some companies persist in their efforts to challenge the status quo? The answer: the promise that diversity can create powerful options for a highly productive, synergistic workplace. Forward-thinking executives and managers know that their workforces will only grow more diverse. The sooner the organization fosters an environment where individuals and teams learn to work well together, the faster it achieves a competitive edge in an increasingly challenging marketplace. The Promise of Diversity is a contemporary, future-focused business anthology that represents the views of over 40 leaders, researchers, and practitioners who are actively working to address issues of oppression and diversity in organizations. Their enlightening essays cover such topics as throwing away the "melting pot" idea and regarding diversity as a strength, optimizing the value of individual difference through an organizational systems approach, developing cross-gender partnerships, the white male's current position at the intersection of race and gender, sexual orientation as a workforce diversity issue, and the problems faced by white women and women of color. Here are the hopes, fears, and dreams of leading change agents regarding the promise (and perils) of truediversityin the workplace. Representing each author's voice, style, and point of view, this collection of insightful articles is itself a living example of diversity and is destined to become a classic reference in its field.
Trust and TAM in Online Shopping: An Integrated Model

A separate and distinct interaction with both the actual e-vendor and with its IT Web site interface is at the heart of online shopping. Previous research has established, accordingly, that online purchase intentions are the product of both consumer assessments of the IT itself-specifically its perceived usefulness and ease-of-use (TAM)-and trust in the e-vendor. But these perspectives have been examined independently by IS researchers. Integrating these two perspectives and examining the factors that build online trust in an environment that lacks the typical human interaction that often leads to trust in other circumstances advances our understanding of these constructs and their linkages to behavior. Our research on experienced repeat online shoppers shows that consumer trust is as important to online commerce as the widely accepted TAM use-antecedents, perceived usefulness and perceived ease of use. Together these variable sets explain a considerable proportion of variance in intended behavior. The study also provides evidence that online trust is built through (1) a belief that the vendor has nothing to gain by cheating, (2) a belief that there are safety mechanisms built into the Web site, and (3) by having a typical interface, (4) one that is, moreover, easy to use.