Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Music Therapy on Anxiety and Depression in Patients with Alzheimer’s Type Dementia: Randomised, Controlled Study

Background/Aims: Numerous studies have indicated the value of music therapy in the management of patients with Alzheimer’s disease. A recent pilot study demonstrated the feasibility and usefulness of a new music therapy technique. The aim of this controlled, randomised study was to assess the effects of this new music therapy technique on anxiety and depression in patients with mild to moderate Alzheimer-type dementia. Methods: This was a single-centre, comparative, controlled, randomised study, with blinded assessment of its results. The duration of follow-up was 24 weeks. The treated group (n = 15) participated in weekly sessions of individual, receptive music therapy. The musical style of the session was chosen by the patient. The validated ‘U’ technique was employed. The control group (n = 15) participated under the same conditions in reading sessions. The principal endpoint, measured at weeks 1, 4, 8, 16 and 24, was the level of anxiety (Hamilton Scale). Changes in the depression score (Geriatric Depression Scale) were also analyzed as a secondary endpoint. Results: Significant improvements in anxiety (p < 0.01) and depression (p < 0.01) were observed in the music therapy group as from week 4 and until week 16. The effect of music therapy was sustained for up to 8 weeks after the discontinuation of sessions between weeks 16 and 24 (p < 0.01). Conclusion: These results confirm the valuable effect of music therapy on anxiety and depression in patients with mild to moderate Alzheimer’s disease. This new music therapy technique is simple to implement and can easily be integrated in a multidisciplinary programme for the management of Alzheimer’s disease.
Microdeletion del(22)(q12.1) excluding the MN1 gene in a patient with craniofacial anomalies

Several studies have recently reported that 22q12.1 deletions encompassing the MN1 gene are associated with craniofacial anomalies. These observations are consistent with the hypothesis that MN1 haploinsufficiency may be solely responsible for craniofacial anomalies and/or cleft palate. We report here the case of a 4‐year‐old boy presenting with global developmental delay and craniofacial anomalies including severe maxillary protrusion and retromicrognathia. Array‐CGH detected a 2.4 Mb de novo deletion of chromosome 22q12.1 which did not encompass the MN1 gene thought to be the main pathological candidate in 22q12.1 deletions. This observation, combined with data from other patients from the Database of Chromosomal Imbalance and Phenotype in Humans Using Ensemble Resources (DECIPHER), suggests that other gene(s) in the 22q12.1 region are likely involved in craniofacial anomalies and/or may contribute to the phenotypic variability observed in patients with MN1 deletion. © 2015 Wiley Periodicals, Inc.
Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis.

AIMS Leukotriene B4 (LTB4) is a powerful chemoattractant and pro-inflammatory mediator in several inflammatory diseases, including atherosclerosis. It acts through its two membrane receptors, BLT1 and BLT2. The aim of this study was to determine the molecular mechanism involved in the proatherogenic effect of LTB4, BLT1 and BLT2 in atherosclerosis. Moreover, we characterized the expression of 5-lipoxygenase (5-LO) pathway and LTB4 receptors in blood and plaques from patients with carotid atherosclerosis. METHODS AND RESULTS In cultured monocytic cells, LTB4 induced a rapid phosphorylation of mitogen-activated protein kinases (MAPKs ERK1/2 and JNK1/2) and PI3K/Akt via BLT1 and BLT2 in a pertussis toxin (PTX)-dependent mechanism (assessed via western blotting) and also increased nuclear factor-kappaB (NF-kappaB) DNA binding activity (assessed via EMSA) in a MAPK- and reactive oxygen species-dependent mechanism. Furthermore, LTB4 elicited interleukin-6, monocyte chemoattractant protein-1 and tumour necrosis factor-alpha mRNA overexpression also via BLT1 and BLT2 by a PTX- and NF-kB-dependent mechanism (assessed by real-time PCR), promoting an inflammatory environment. When compared with healthy subjects, patients with carotid atherosclerosis showed a significant increase in the expression of all the components of the 5-LO pathway and BLT1 and BLT2 mRNA (real-time PCR) in peripheral blood mononuclear cells and LTB4 plasma levels (ELISA). In these patients, an overexpression of 5-LO, leukotriene A-4 hydroxylase (LTA4-H) and BLT1 was noted in the inflammatory region of carotid plaques when compared with the fibrous cap (assessed by immunohistochemistry). CONCLUSION The 5-LO pathway is enhanced in patients with carotid atherosclerosis. Furthermore, its product LTB4 phosphorylates MAPKs and stimulates NF-kappaB-dependent inflammation via BLT1 and BLT2 receptors in cultured monocytic cells. The blockade of this pathway could be a novel and potential therapeutic target in atherothrombosis.
Investigations on blink reflexes in humans

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Properties of Fixed-Fixed Models and Alternatives in Presence-Absence Data Analysis

Assessing the significance of patterns in presence-absence data is an important question in ecological data analysis, e.g., when studying nestedness. Significance testing can be performed with the commonly used fixed-fixed models, which preserve the row and column sums while permuting the data. The manuscript considers the properties of fixed-fixed models and points out how their strict constraints can lead to limited randomizability. The manuscript considers the question of relaxing row and column sun constraints of the fixed-fixed models. The Rasch models are presented as an alternative with relaxed constraints and sound statistical properties. Models are compared on presence-absence data and surprisingly the fixed-fixed models are observed to produce unreasonably optimistic measures of statistical significance, giving interesting insight into practical effects of limited randomizability.
A survey of managed honey bee colony losses in the USA, fall 2009 to winter 2010

Summary This study records the fourth consecutive year of high winter losses in managed honey bee (Apis mellifera) colonies in the USA. Over the winter of 2009–2010, US beekeepers responding to this survey lost an average of 42.2% of their colonies, for a total loss of 34.4%. Commercial beekeepers (those operating more than 500 colonies) experienced lower total losses as compared to sideline and backyard beekeepers. Similarly, operations that maintained colonies in more than one state and operations that pollinated almond orchards over the survey period had lower total losses than operations either managing colonies in one state exclusively or those not pollinating almonds. On average beekeepers consider acceptable losses to be 14.5%, and 65% of all responding beekeepers suffered losses in excess of what they considered acceptable. The proportion of operations that experienced losses and reported having no dead bees in their colonies or apiaries was comparable to that reported in the winter of 2008–2009. Manageable conditions, such as starvation and a weak condition in the fall were the leading self-identified causes of mortality as reported by all beekeepers. Commercial beekeepers were, however, less likely to list such manageable causes, instead listing poor queens, mites, and pesticides most frequently as the self-identified causes of mortality in their operations.
Prevalence of colibacillosis in chickens in greater Mymensingh district of Bangladesh

Aim: This study was conducted for determination of the prevalence of colibacillosis in chicken in poultry farms in Mymensingh and Tangail districts. Isolation, identification, and antibiogram profile of Escherichia coli were also performed. Materials and Methods: A total of 25 chickens manifested clinical signs of colibacillosis were collected from five different poultry farms during natural outbreaks. Results: In broiler, the prevalence of colibacillosis was 0.84%, and in layer, prevalence was 0.80%. The prevalence of colibacillosis was 1.0% and 0.5% in 25-30 days old and 31-35 days old broiler, respectively. In case of layer birds, the prevalence was 0.6% in 40-45 days old bird and 1% in 46-50 days old bird. Identity of the E. coli isolate of chicken was confirmed by sugar fermentation, biochemical tests, and polymerase chain reaction assay. Antibiogram profile of E. coli isolate of chicken revealed that it was multidrug resistant (resistant against two antibiotics, such as ampicillin and cefalexin). Conclusion: Data of this study suggest that colibacillosis is prevalent in the study areas which underscore the need of implementation of prevention and control measure against this disease.
Analysis of Bias Stress Instability in Amorphous InGaZnO Thin-Film Transistors

In this paper, we report an analysis of electrical bias stress instability in amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs). Understanding the variations of TFT characteristics under an electrical bias stress is important for commercial goals. In this experiment, the positive gate bias is initially applied to the tested a-IGZO TFTs, and subsequently, the negative gate bias is applied to the TFTs. For comparison with the subsequently negative-gate-bias-applied TFTs, another experiment is performed by directly applying the negative gate bias to the tested TFTs. For the positive gate bias stress, a positive shift in the threshold voltage (Vth) with no apparent change in the subthreshold swing (SSUB) is observed. On the other hand, when the negative gate bias is subsequently applied, the TFTs exhibit higher mobility with no significant change in SSUB, whereas the shift of the Vth is much smaller than that in the positive gate bias stress case. These phenomena are most likely induced by positively charged donor-like subgap density of states and the detrapping of trapped interface charge during the positive gate bias stress. The proposed mechanism was verified by device simulation. Thus, the proposed model can explain the instability for both positive and negative bias stresses in a-IGZO TFTs.
On random network coding based information dissemination

We study the gains to be had by using random linear coding (RLC) for simultaneously disseminating k distinct messages in a network of n nodes in a decentralized and distributed manner for arbitrary k and n. The goal is to rapidly disseminate all the messages among all the nodes. Any node can communicate with any of the other nodes but only one at a time, nodes only have knowledge about their own contents, and the bandwidth for every transmission between two nodes is limited (does not scale with k or n). An efficient and well-studied protocol for message dissemination in such a framework is randomized gossip based message dissemination. The problem has been studied extensively without using any coding for message dissemination. We show using analysis and simulation that, in the regime k ges (ln(n))3, RLC based dissemination reduces the dissemination time (the time-steps to disseminate all the messages among all the nodes) by a factor of otimes(ln(n)) as compared to disseminating the messages sequentially (i.e., one after the other) as implicit in most non-coding based technique. In the regime k les (ln(n))2, the dissemination time with RLC goes down by a factor of Omega(radick / ln k). More precisely, our results indicate that a RLC based protocol disseminates all the messages among all the nodes in time ck + O(radick ln(k)(ln(n)) for a suitable constant c > 0. Analytical results show that, c < 3.46 using pull based dissemination, and c < 5.96 using push based dissemination, but reported simulations suggest c < 2 might be a tighter bound
SuperFreakonomics: Global Cooling, Patriotic Prostitutes, and Why Suicide Bombers Should Buy Life Insurance

Here at last is the long awaited sequel to the international bestselling phenomenon, Freakonomics. Steven Levitt, the original rogue economist, and Stephen Dubner have been working hard, uncovering the hidden side of even more controversial subjects, from charity to terrorism and prostitution. And with their inimitable style and wit, they will take us on another even more gripping journey of discovery. "Superfreakonomics" will once again transform the way we look at the world.
Intermittent fault diagnosis of industrial systems in a model-checking framework

In this paper, a formal verification approach for diagnosability analysis of intermittent faults is proposed. In this approach, the industrial systems are abstracted as discrete-event systems (DES) and modeled by finite state automata (FSA), then a model-checking framework is set to deal with diagnosability issues. Intermittent faults are defined as faults that can automatically recover once they occur. We first revisit two existing definitions of diagnosability of intermittent faults, regarding the occurrence of faults and their normalization (i.e., disappearance of faults). Then, necessary and sufficient conditions are developed based on the twin plant construction, and reformulated as linear temporal logic (LTL) formulas in order to use model-checking for actual verification. A benchmark is used to illustrate the contributions discussed and to assess the efficiency and the scalability of the proposed approach.1
Childhood Sexual Abuse and the Perpetration of Violence: The Moderating Role of Gender

This study sought to increase specificity in our knowledge of links among child sexual abuse (CSA), aggression, and physical intimate partner violence (IPV) perpetration by criminal offenders, with particular interest in gender. Participants were 202 men and 72 women (N = 274), who were recruited from an urban pretrial supervision program. Women reported higher rates of CSA than men. After controlling for relevant covariates, CSA was associated with general aggression and severe IPV. We found a gender by CSA interaction; CSA was associated with aggression and severe IPV for women, but not men. Findings provide preliminary evidence that CSA impacts aggression and IPV perpetration differently for female offenders compared to male offenders and gender-specific treatment might be warranted in pretrial settings.
Appraisal theory and emotional sequelae of first visit to colposcopy following an abnormal cervical screening result.

OBJECTIVES Attendance at colposcopy following an abnormal cervical smear is potentially a highly distressing event. This study evaluates the role of cognitive appraisal components (Lazarus, 1991; Smith et al., 1993) in explaining emotional reactions to this event. We also compare the psychological sequelae of immediate treatment at first colposcopy (See and Treat, ST) vs. colposcopy with treatment deferred to a later date (Diagnose and Defer, DD). METHOD One thousand and eighty-five women referred for colposcopy completed a questionnaire assessing appraisal and emotion following their attendance. Clinical data were abstracted from medical records and social deprivation scores were estimated from postal code information based on normative data. RESULTS Diagnosis and cognitive appraisals were each significantly associated with emotion, together accounting for between 3 and 15% of variance in different emotions. Specific patterns of appraisal explained specific emotions in line with theoretical predictions. Women with Cervical Intraepithelial Neoplasia (CIN) 2 or CIN 3 undergoing 'ST' were less anxious, less embarrassed and significantly more relieved compared with a matched sample of women undergoing 'DT', and perceived their first appointment as more motivationally congruent. CONCLUSION Diagnosis, motivationally incongruent experiences and low emotion-focused coping potential are the most important determinants of anxiety after colposcopy. 'See and Treat' appears to have a positive psychological impact by increasing motivational congruence.
The effects of trunk kinesio taping on balance ability and gait function in stroke patients

[Purpose] Kinesio taping is a therapeutic method used in the treatment of various musculoskeletal and neuromuscular deficits, but there is limited evidence of the effects of trunk kinesio taping in neurologic patients. Therefore, this study aimed to determine the effects of trunk kinesio taping on balance ability and gait function in persons after a stroke. [Subjects and Methods] Twenty-five post-stroke patients were included in this study. Kinesio tape was applied to four trunk muscles. Before and after the taping, in all subjects, the balance ability was measured using the Wii Balance Board, and gait function was assessed using the GAITRite system. [Results] The difference in gait function before and after trunk taping was not statistically significant. However, a variability of balance ability showed statistically significant differences. [Conclusion] These results suggest that taping may be a helpful method during rehabilitation programs for stroke patients. Its application to the trunk muscles is especially useful for improving balance ability.
Transforming students: fulfilling the promise of higher education

The recent trend of trying to measure higher education's return on investment misses a fundamental point, argue Charity Johansson and Peter Felten. The central purpose of a college or university is to transform the lives of students-not to merely change them or help them mature. This transformation is an ongoing process of intentionally aligning one's behavior with one's core sense of personal identity. It is the university's central role to lead students in this transformation, a process that shapes students into intentional, critical, and engaged individuals. Recognizing the remarkable influence of the college experience on peoples' lives, the authors offer a guide to how colleges and universities can effectively lead students through this life-changing process. Drawn from extensive interviews with students and graduates, faculty and staff, Transforming Students gathers diverse stories to show how students experience the transformation process, which rarely follows a neat or linear path. The interviews illustrate central themes from the literature on transformative learning and the undergraduate student experience. A sequel of sorts to George Keller's classic Transforming a College - which chronicled Elon University's metamorphosis from struggling college to a top regional university- Transforming Students addresses the school's core educational mission: to shape students into engaged adults who embrace learning as a lifelong endeavor. Given this effect, the college experience is much more than preparation for a career. It is preparation for life.
The Rorschach: A Developmental Perspective

Part I: Young Children and the Rorschach. Studies of the Rorschach in Early Childhood. Methodological Issues. Patterns of Early Rorschach Performance. The Preschool Rorschach Literature: Concensus, Controversy, and Synthesis. Part II: Stages in the Mastery of the Rorschach. Characteristics of the Model. Stage I: Perseverative Approaches to the Rorschach. Stage II: Confabulatory Approaches to the Rorschach. Stage III: "The Rorschach. " Part III: Psychosocial Aspects of the Rorschach Test. Formulating the Problem. An Ego-Psychological Perspective on Preschoolers' Handling of the Rorschach. Work and Play. Interpersonal Aspects of the Rorschach Situation. The Rorschach Situation and the Orthogenetic Principle. Part IV. Cognitive Aspects of the Rorschach Test. The Perception Hypothesis. Rorschach Perception Hypotheses. A Critique of the Expanded Perception Hypotheses. Alternatives to the Perception Hypotheses. The Rorschach and Representation I: The Nature of Projective Tests. The Rorschach and Representation II: The Symbol Situation. The Rorschach and Representation III: Conceptualizing Primary Aspects of the Test. Representation and Children's Rorschachs. Part V: Clinical Applications. Problems in the Clinical Assessment of Young Children. A Clinical-Developmental Approach to Preschool Rorschachs. The Rorschach and Severly Disturbed Children. The Rorschach and Thought Disorder.
Effects of Different pH-Values on the Nanomechanical Surface Properties of PEEK and CFR-PEEK Compared to Dental Resin-Based Materials

The study determines the stability and durability of polyetheretherketone (PEEK) and a carbon fiber-reinforced PEEK (CFR-PEEK) with 30% short carbon fibers, a dental composite based on Bis-GMA and polymethylmethacrylate (PMMA) under the influence of different pH-values of the oral environment in vitro. Nanomechanical properties were investigated by nanoindentation and nanoscratch tests before and after incubation of the specimens at 37 °C for 30 days in artificial saliva with pH-values of 3, 7 and 10, respectively. Nanoindentation and nanoscratching tests were performed using the Hysitron TI950 TriboIndenter to evaluate the reduced elastic moduli, nanohardness, viscoelasticity, friction coefficient and residual scratch profiles. After treatment, the nanomechanical properties of unfilled PEEK did not change. The reduced elastic moduli and nanohardness of the carbon fiber-reinforced PEEK increased significantly. The reduced elastic moduli and nanohardness of CHARISMA decreased. The plasticity of all materials except that of the unfilled PEEK increased. This indicates that different pH-values of the artificial saliva solutions had no obvious influences on the nanomechanical properties of the PEEK matrix. Therefore, the aging resistance of the unfilled PEEK was higher than those of other materials. It can be deduced that the PEEK matrix without filler was more stable than with filler in the nanoscale.
Making Better Use of Global Discretization

Before applying learning algorithms to datasets, practitioners often globally discretize any numeric attributes. If the algorithm cannot handle numeric attributes directly, prior discretization is essential. Even if it can, prior discretization often accelerates induction, and may produce simpler and more accurate classi ers. As it is generally done, global discretization denies the learning algorithm any chance of taking advantage of the ordering information implicit in numeric attributes. However, a simple transformation of discretized data preserves this information in a form that learners can use. We show that, compared to using the discretized data directly, this transformation signi cantly increases the accuracy of decision trees built by C4.5, decision lists built by PART, and decision tables built using the wrapper method, on several benchmark datasets. Moreover, it can signi cantly reduce the size of the resulting classi ers. This simple technique makes global discretization an even more useful tool for data preprocessing.