Miracle-dz/UniFAR-FTUs huggingface dataset:
Proteomic Changes during B Cell Maturation: 2D-DIGE Approach

B cells play a pivotal role in adaptive immune system, since they maintain a delicate balance between recognition and clearance of foreign pathogens and tolerance to self. During maturation, B cells progress through a series of developmental stages defined by specific phenotypic surface markers and the rearrangement and expression of immunoglobulin (Ig) genes. To get insight into B cell proteome during the maturation pathway, we studied differential protein expression in eight human cell lines, which cover four distinctive developmental stages; early pre-B, pre-B, plasma cell and immature B cell upon anti-IgM stimulation. Our two-dimensional differential gel electrophoresis (2D-DIGE) and mass spectrometry based proteomic study indicates the involvement of large number of proteins with various functions. Notably, proteins related to cytoskeleton were relatively highly expressed in early pre-B and pre-B cells, whereas plasma cell proteome contained endoplasmic reticulum and Golgi system proteins. Our long time series analysis in anti-IgM stimulated Ramos B cells revealed the dynamic regulation of cytoskeleton organization, gene expression and metabolic pathways, among others. The findings are related to cellular processes in B cells and are discussed in relation to experimental information for the proteins and pathways they are involved in. Representative 2D-DIGE maps of different B cell maturation stages are available online at http://structure.bmc. lu.se/BcellProteome/.
Opening classroom interaction: the importance of feedback

Efforts to encourage ‘interactive practice’ in the National Literacy (NLS) and Numeracy (NNS) Strategies in the UK, have led to an emphasis on teacher questions. Recent research into classroom interactions, however, indicate that the pattern of interaction remains largely unchanged since the introduction of these strategies in terms of the type and amount of questions teachers are asking, and the opportunities for extended pupil participation. This article uses evidence gathered from a large‐scale research project examining classroom interactions during literacy and numeracy lessons, and the researchers' critical reflections upon this process, to examine conceptions of interactive pedagogy. It is argued that in order to ‘open’ classroom interaction, emphasis should be less on the questions teachers ask, and more on the manner with which teachers react to pupils' responses to questions. Episodes of classroom interaction from video recorded literacy and numeracy lessons taken as part of the study are used to support this argument. They present evidence of teacher behaviours in reaction to pupils' responses which succeed in facilitating a more interactive learning environment. The implication that such behaviour will contribute towards a model of effective interactive practice is also discussed.
Are infinitival to omission errors primed by prior discourse? The case of WANT constructions

Abstract This paper examines the suggestion that infinitival to omission errors in English-speaking children can result from competition between two constructions (Kirjavainen et al., First Language 29: 313–339, 2009a). Kirjavainen et al. suggested that the acquisition of two (or more) constructions (e.g., WANT-X and WANT-to) for verbs taking to-infinitival complement clauses can lead to infinitival to omissions, reflecting the relative frequencies of the constructions in the input. In the present study we analysed 13 English children's corpora to determine whether the presence of a variety of utterance types in the immediate discourse context preceding WANT-to-VP (e.g., I want to eat it) and erroneous *WANT-zero-VP (e.g., *I want __ drink it) constructions was associated with infinitival to production/omission. This was done separately for the children's own and their interlocutors' discourse utterances. The data show that the occurrence of WANT-to and WANT-X constructions in the prior discourse was associated with differing proportions of infinitival to provision in the WANT-to/zero-VP construction. This together with Kirjavainen et al.'s (First Language 29: 313–339, 2009a) data suggests that children are learning at least two constructions for the verb WANT, that competition contributes to infinitival to omissions, and that the strength of competing representations is affected by overall input frequencies and the preceding discourse.
Mucocutaneous Involvement in Behçet's Disease: How Systemic Treatment Has Changed in the Last Decades and Future Perspectives

Behçet's disease (BD) is a multisystemic disorder of unknown etiology characterized by the “triple symptom complex” consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis. Recurrent mucocutaneous lesions are generally considered the hallmark of the disease, being the most common symptoms presenting at the onset of disease. Although the improvement of knowledge about the pathogenetic mechanism added important changes in the treatment management of BD clinical manifestations, thus avoiding the appearance of serious life-threatening complications which are disease related, the mucocutaneous lesions are still the most nagging clinical manifestations to be treated. In this work we reviewed the current state of knowledge regarding the therapeutic approaches for mucocutaneous lesions of BD mainly based on controlled studies to provide a rational framework for selecting the appropriate therapy for treating these troublesome features of the disease.
Learning Lessons and Transferring Policy across Time, Space and Disciplines

An area of recent interest in the International Relations and Comparative Politics literature concerns ‘policy transfer’. This is a dynamic whereby knowledge about policies, administrative arrangements or institutions is used across time or space in the development of policies, administrative arrangements and institutions elsewhere. Policy transfer is deemed to be on the increase in an era of globalisation. Indeed, some governments and international organisations are proactive in promoting harmonisation and convergence or exporting policy lessons. This paper surveys the state of the burgeoning literature, identifies some methodological issues in studying policy transfer, and outlines some additional routes of research.
Commitment to Nested Collectives in Special Operations Forces

Contemporary investigations of workplace commitment include research on commitment components and commitment to multiple, and sometimes nested, work units. Research on commitment within the hierarchical military structure may be particularly reflective of these perspectives. Affective commitment to 2 nested organizational units (Special Operations Forces and the military) was hypothesized to be distinguishable from each another and from military continuance commitment. Further, a model portraying the hypothesized relations between satisfaction and affective commitment for the 2 organizational units and career intentions was examined. Special Operations personnel (n = 3,968) from 3 service branches completed satisfaction and career intentions items in addition to modified versions (Gade, Tiggle, & Schumm, 2003/this issue) of the Meyer and Allen (1984) commitment scales. Results of the research supported the distinction between the commitment scales and provided support for the model. Implications for operational environments and future research are discussed.
TEDI: efficient shortest path query answering on graphs

Efficient shortest path query answering in large graphs is enjoying a growing number of applications, such as ranked keyword search in databases, social networks, ontology reasoning and bioinformatics. A shortest path query on a graph finds the shortest path for the given source and target vertices in the graph. Current techniques for efficient evaluation of such queries are based on the pre-computation of compressed Breadth First Search trees of the graph. However, they suffer from drawbacks of scalability. To address these problems, we propose TEDI, an indexing and query processing scheme for the shortest path query answering. TEDI is based on the tree decomposition methodology. The graph is first decomposed into a tree in which the node (a.k.a. bag) contains more than one vertex from the graph. The shortest paths are stored in such bags and these local paths together with the tree are the components of the index of the graph. Based on this index, a bottom-up operation can be executed to find the shortest path for any given source and target vertices. Our experimental results show that TEDI offers orders-of-magnitude performance improvement over existing approaches on the index construction time, the index size and the query answering.
Understanding VET teachers’ challenges in providing quality education to international students

Abstract In the past fifteen years, increasing attention has been given to the role of Vocational Education and Training (VET) in attracting large numbers of international students and its contribution to the economic development of Australia. This trend has given rise to many challenges in vocational education, especially with regard to providing quality education that ensures international students stay in Australia is a satisfactory experience. Teaching and learning are continuously scrutinised, and teaching quality and student assessment are subject to regular audit (Takerei, 2010). VET teachers are key stakeholders in international education and share responsibility for ensuring international students gain quality learning experiences and positive outcomes; however, their experiences are generally not well understood. Therefore, this paper reports on a study which responded to this research gap and investigated particular challenges that VET teachers experience when teaching international students. The research participants were 15 teachers from several public and private VET institutions in Brisbane, Australia. The method involved responsive interviewing and inductive data analysis to identify and categorize teachers’ challenges and dilemmas. After briefly outlining the background of the research approach, this paper presents findings about challenges that VET teachers’ experienced while teaching international students. The aim of the paper is to explore VET teachers’ perspectives in order to contribute essential understandings that contribute to a holistic approach to vocational education of international students. It reveals that the teachers experienced challenges of three main types: professional, personal and educational.
Linking wheelchair kinetics to glenohumeral joint demand during everyday accessibility activities

The aim of the study was to investigate if push-rim kinetics could be used as markers of glenohumeral joint demand during manual wheelchair accessibility activities; demonstrating a method of biomechanical analysis that could be used away from the laboratory. Propulsion forces, trunk and upper limb kinematics and surface electromyography were recorded during four propulsion tasks (level, 2.5% cross slope, 6.5% incline and 12% incline). Kinetic and kinematic data were applied to an OpenSim musculoskeletal model of the trunk and upper limb, to enable calculation of glenohumeral joint contact force. Results demonstrated a positive correlation between propulsion forces and glenohumeral joint contact forces. Both propulsion forces and joint contact forces increased as the task became more challenging. Participants demonstrated increases in trunk flexion angle as the requirement for force application increased, significantly so in the 12% incline. There were significant increases in both resultant glenohumeral joint contact forces and peak and mean normalized muscle activity levels during the incline tasks. This study demonstrated the high demand placed on the glenohumeral joint during accessibility tasks, especially as the gradient of incline increases. A lightweight instrumented wheelchair wheel has potential to guide the user to minimize upper limb demand during daily activity.
Expected Closeness or Mobilisation: Why Do Voters Go to the Polls? Empirical Results for Switzerland, 1981 - 1999

Using data of Swiss referenda from 1981 to 1999, this paper presents new empirical results which allow us to discriminate better between the decision and mobilisation hypotheses of electoral participation. First, theoretical considerations which lead to these hypotheses are presented as well as the theory of expressive voting, and a survey of the available empirical evidence is given. Then, we describe the empirical approach before we come to its results. Those are much in line with the mobilisation but do not support the decision hypothesis. They are, however, also only partly compatible with the theory of expressive voting.
Theory and Practice in Latin American Alternative Communication Research.

Au cours des annees 1970, la recherche en communication de l'Amerique latine s'est tournee vers d'autres conceptions des theories de la communication, referee desormais comme la communication alternative. De nos jours, et bien que faisant face a des conditions politiques et sociales qui sont passees de regimes repressifs a des regimes plus democratiques, les chercheurs semblent etre dans une phase de confusion theorique, dans une incapacite de repondre efficacement au nouveau liberalisme ambiant. Pour les AA. , un certain nombre de reponses a la creation mediatique democratique se trouvent dans la litterature de cette communication alternative pour laquelle ils proposent une revue complete de question, avec comme objectif principal de la porter a la connaissance des chercheurs non-hispanophones
Solving Geometric Problems in Space-Conscious Models

When dealing with massive data sets, standard algorithms may easily “run out of memory”. In this thesis, we design efficient algorithms in space-conscious models. In particular, in-place algorithms, multi-pass algorithms, read-only algorithms, and stream-sort algorithms are studied, and the focus is on fundamental geometric problems, such as 2D convex hulls, 3D convex hulls, Voronoi diagrams and nearest neighbor queries, Klee’s measure problem, and low-dimensional linear programming. In-place algorithms only use O(1) extra space besides the input array. We present a data structure for 2D nearest neighbor queries and algorithms for Klee’s measure problem in this model. Algorithms in the multi-pass model only make read-only sequential access to the input, and use sublinear working space and small (usually a constant) number of passes on the input. We present algorithms and lower bounds for many problems, including low-dimensional linear programming and convex hulls, in this model. Algorithms in the read-only model only make read-only random access to the input array, and use sublinear working space. We present algorithms for Klee’s measure problem and 2D convex hulls in this model. Algorithms in the stream-sort model use sorting as a primitive operation. Each pass can either sort the data or make sequential access to the data. As in the multi-pass model, these algorithms can only use sublinear working space and a small (usually a constant) number of passes on the data. We present algorithms for constructing convex hulls and polygon triangulation in this model.
Circumstantial development and athletic excellence: The role of date of birth and birthplace

Abstract Researchers are only beginning to understand how contextual variables such as date of birth and birthplace affect the development of elite athletes. This article considers the generality of birthplace and date-of-birth effects in varying sport contexts. The Study 1 examined how environmental factors associated with an athlete's date-of-birth and size of birthplace predict the likelihood of becoming an Olympic athlete in Canada, the United States of America, Germany, and the United Kingdom. Study 2 examined date-of-birth and birthplace effects among athletes playing in the first professional league in Germany. Study 2 also examined the validity of birthplace as a proxy for early developmental environment by comparing birthplace with the place of first sports club in four German sports leagues. Results from both studies showed no consistent findings for date of birth. Findings from Study 2 also suggested incongruence between birthplace and location of first sports club as proxies for early developmental environment. Although there was some consistency suggesting elite athletes are less likely to come from very small or excessively large communities, exceptions occurred both within and across sport contexts. These results suggest that any developmental effects of date and place of birth are buffered by broader socio-cultural factors.
Minority language speakers as migrants: some preliminary observations on the Sudanese community in Melbourne

The language problems faced by migrants may be more complex when they come from a minority language group in their homeland. The new arrivals may find that there are few, or even no, speakers of their language in the community to which they have moved. Then decisions have to be made as to whether to attempt to maintain the native language and also whether to join in larger groupings of people from the country of origin, groups that may use dominant languages of the home country or other languages of wider communication. Such migrants can be expected to be involved in various networks based on different languages and to have complex allegiances and identities involving the various networks and languages. We explore these issues by considering the case of speakers of minority languages from Sudan who have settled in Melbourne. More than 40 languages are represented in this community and most of these are minority languages in Sudan. We present three case studies of members of this community and discuss the social networks that are available to speakers of these languages and the various factors that influence the language use and language choices of the people from these groups.
Innovation in clusters: exploration capacity, networking intensity and external resources

Purpose – The purpose of this paper is to present an integrated model of the determinants of innovation in clusters. In the understanding, internal, external and relational dimensions must be considered to make up a complete picture of the innovation processes. The authors propose that the exploration capacity of the firm, as well as its networking intensity and the external resources provided by supporting organizations are relevant in this context. Design/methodology/approach – The empirical study has drawn on the population of the firms belonging to the Valencian textile industrial cluster in Spain and was carried out in two different phases. In the first step the authors applied the social network analysis technique to study the relational structure of the participating companies, followed by a second analysis aimed at performing a more detailed analysis of the companies that answered the roster by means of face-to-face interviews. Findings – Results suggest that firms in clusters must develop individ.
Educational Middle Change Leadership in New Zealand: The Meat in the Sandwich.

Purpose – The purpose of this paper is to report findings from a larger study into the role of middle leaders of change in New Zealand higher education.Design/methodology/approach – In total, ten middle leaders from the New Zealand higher education sector took part in a recent research project which examined successful change leadership in higher education. As part of that larger study, each middle leader answered questions about their views on being in the “middle” in their change leadership roles and their views on middle leadership in general.Findings – The ten middle leaders all described their place in their respective organisations in terms of being “caught in between”, or “sandwiched between” senior management to whom they were accountable, lecturers whom they described as colleagues or peers, and subordinates for whom they had some functional and often moral responsibility. The paper discusses the perceptions of being in the “middle” and how change leaders reconcile their position as a subordinate.
Applying compositional data methodology to nutritional epidemiology

The purpose of epidemiological studies of nutrition and disease is to investigate the effects of specific dietary components regardless of total energy intake, but this is sometimes hampered by the compositional nature of dietary data. Compositional data are those that measure parts of a whole, such as percentages or proportions, and particular methodologies have been developed to allow their statistical analysis and theoretical and practical applications in various sciences. This paper describes the use of a compositional data perspective for statistical analyses in the field of nutritional epidemiology. The approach is based on isometric log-ratio transformation and has been previously proposed for the construction of regression models using compositional explanatory variables. The new isometric log-ratio variables allow full inferences about each element of dietary composition and adjustment by total energy intake. Using data from an Italian population-based study, logistic regression models were fitted to evaluate the effects of the intake of macronutrients (proteins, fats and carbohydrates) on the odds of having metabolic syndrome in middle-aged subjects.
The Influence of Personal History on Preservice Malay, Tamil and Chinese Teacher Thinking

Abstract Explorations of preservice teacher thinking in the West illustrate the considerable influence that personal history can exert on the developing cognition of teachers. This paper extends the discussion by providing a cross-cultural perspective of Asian preservice teacher constructs of the ideal language teacher. Participants in this study were all preservice language teachers training to be specialist Malay, Tamil, Chinese or English language teachers in Singapore. Data was collected through the use of written biography, metaphor and personal construct interviews. Analysis of data reveals that preservice language teachers enter formal teacher education with well developed constructs or views of the ideal language teacher and related approaches to language learning.
Inclusion in Elementary Schools

This study of reform policy focused on inclusive education in the 1990s in the state of Georgia, United States of America. Program modifications including, individualizing instructional methods, adapting the instructional environment, and lowering maximum class size emerged as significant issues. We found that policies related to these areas were compounded by the less experienced educators not readily accepting change strategies for serving students. Apparently younger educators are engrossed in surviving daily routine and have difficulty coping with the complex demands of change. Regular education teachers have difficulty with the idea of inclusion. Legal aspects dealing inclusion need clarification, especially for regular education teachers.