Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of an Indoor Photovoltaic Energy Harvesting Module for Autonomous Sensors in Building Air Quality Applications

A 50 mm <inline-formula> <tex-math notation="LaTeX">${\times } \,\, 20$ </tex-math></inline-formula> mm <inline-formula> <tex-math notation="LaTeX">${\times } \,\, 15$ </tex-math></inline-formula> mm indoor photovoltaic (PV) energy harvesting power module (IPEHPM) has been developed for powering an Internet of Things (IoT) sensor node containing a low-power CO<sub>2</sub> sensor for automatic building ventilation. It is composed of a high efficiency PV energy harvesting module and a supercapacitor to produce 3.6–4.2 V output voltage with 100 mA pulse current for up to 600 ms. Storage efficiency analysis and storage efficiency tests of the IPEHPM have demonstrated that with the adopted simple power management scheme, which exempts the commonly used power management blocks of the voltage regulator and the maximum power point tracking to save power, 88.7% average storage efficiency has been achieved at 200 lux. With the newly established PV powering model, the power consumption requirements of an IoT node can be directly converted into the illumination requirements of the PV energy harvester, making the IPEHPM easy to use. IPEHPM powered IoT experiments with a low-power CO<sub>2</sub> gas sensor have demonstrated that the IPEHPM is suitable for IoT-based building ventilation applications, where the CO<sub>2</sub> concentration level is measured every 150 s at the indoor lighting condition down to 200 lux.
Acoustic Analysis of Preschool Children's Speech

In this paper, changes in acoustic characteristic of young children speech are investigated as a function of age. We examined fundamental frequency, formant frequencies and vowel durations of ten monophtongal vowels from American-English speaking children, age groups 3 to 6. In this study, we also examined the vowel pronunciation variability of young-aged children. The results show that preschool children speech exhibits high fundamental and formant frequencies and greater variations between subjects for all age groups. Individual vowel durations averaged across all subjects in preschooler follows similar pattern for all age groups. Our statistical analysis shows that age effect is significant on pronunciation variability. Finally, an information-theoretic analysis of developmental changes in the speech signal is presented. The findings based on mutual information between the vowel category and the spectral features correspond well with results of automatic vowel recognition.
Casticin impairs cell migration and invasion of mouse melanoma B16F10 cells via PI3K/AKT and NF‐κB signaling pathways

Casticin, a polymethoxyflavone, is one of the major active components obtained from Fructus viticis, which have been shown to have anticancer activities including induce cell apoptosis in human cancer cells. The aim of this study was to investigate the molecular mechanisms by which casticin inhibits cell migration and invasion of mouse melanoma B16F10 cells. Cell viability was examined by MTT assay and the results indicated that casticin decreased the total percentages of viable cells in dose‐dependent manners. Casticin affected cell migration and invasion in B16F10 cells were examined by wound healing mobility assay and Boyden chamber migration and invasion assay and results indicated that casticin inhibited cell migration and invasion in dose‐dependent manners. Western blotting was used to examine the protein expression of B16F10 cells after exposed to casticin and the results showed that casticin decreased the expressions of MMP‐9, MMP‐2, MMP‐1, FAK, 14‐3‐3, GRB2, Akt, NF‐κB p65, SOS‐1, p‐EGFR, p‐JNK 1/2, uPA, and Rho A in B16F10 cells. Furthermore, cDNA microarray assay was used to show that casticin affected associated gene expression of cell migration and invasion and the results indicated that casticin affected some of the gene expression such as increased SCN1B (cell adhesion molecule 1) and TIMP2 (TIMP metallopeptidase inhibitor 2) and decreased NDUFS4 (NADH dehydrogenase (ubiquinone) Fe‐S protein4), VEGFA (vascular endothelial growth factor A), and DDIT3 (DNA‐damage‐inducible transcript 3) which associated cell migration and invasion in B16F10 cells. Based on those observations, we suggest that casticin could be used as a novel anticancer metastasis of melanoma cancer in the future.
Risk factors for offending: A developmental approach

Research has been conducted to identify the risk and protective factors for offending primarily in juveniles; however this research has not extended to high security adult offenders who represent the most significant risk to society. This thesis utilised previously researched risk factor models to identify developmental risk and protective factors and how these increase the likelihood of following an offending pathway in adulthood. This thesis includes a systematic review, review of a psychometric tool, an individual case study and a research paper, which identify specific factors relevant to types of high security offenders. The findings demonstrated that aggression and substance misuse were among the most common risk factors, which began in adolescence and continued into adulthood. Therefore, adult high security offenders could be retrospectively mapped onto juvenile risk factor models, suggesting that the factors identified in high risk samples are primarily developmental in nature. These results demonstrate that interventions with at-risk adolescents may be beneficial in reducing future risk. The findings support previous conclusions in that experiences of increased risk factors in conjunction with few protective factors increases the likelihood of individuals being involved in offending behaviour. Therefore, pro-active and reactive measures should be targeted towards such at-risk individuals.
A Neural Basis of Facial Action Recognition in Humans

By combining different facial muscle actions, called action units, humans can produce an extraordinarily large number of facial expressions. Computational models and studies in cognitive science and social psychology have long hypothesized that the brain needs to visually interpret these action units to understand other people's actions and intentions. Surprisingly, no studies have identified the neural basis of the visual recognition of these action units. Here, using functional magnetic resonance imaging and an innovative machine learning analysis approach, we identify a consistent and differential coding of action units in the brain. Crucially, in a brain region thought to be responsible for the processing of changeable aspects of the face, multivoxel pattern analysis could decode the presence of specific action units in an image. This coding was found to be consistent across people, facilitating the estimation of the perceived action units on participants not used to train the multivoxel decoder. Furthermore, this coding of action units was identified when participants attended to the emotion category of the facial expression, suggesting an interaction between the visual analysis of action units and emotion categorization as predicted by the computational models mentioned above. These results provide the first evidence for a representation of action units in the brain and suggest a mechanism for the analysis of large numbers of facial actions and a loss of this capacity in psychopathologies. SIGNIFICANCE STATEMENT Computational models and studies in cognitive and social psychology propound that visual recognition of facial expressions requires an intermediate step to identify visible facial changes caused by the movement of specific facial muscles. Because facial expressions are indeed created by moving one's facial muscles, it is logical to assume that our visual system solves this inverse problem. Here, using an innovative machine learning method and neuroimaging data, we identify for the first time a brain region responsible for the recognition of actions associated with specific facial muscles. Furthermore, this representation is preserved across subjects. Our machine learning analysis does not require mapping the data to a standard brain and may serve as an alternative to hyperalignment.
Democratizing Content Publication with Coral

CoralCDN is a peer-to-peer content distribution network that allows a user to run a web site that offers high performance and meets huge demand, all for the price of a cheap broadband Internet connection. Volunteer sites that run CoralCDN automatically replicate content as a side effect of users accessing it. Publishing through CoralCDN is as simple as making a small change to the hostname in an object's URL; a peer-to-peer DNS layer transparently redirects browsers to nearby participating cache nodes, which in turn cooperate to minimize load on the origin web server. One of the system's key goals is to avoid creating hot spots that might dissuade volunteers and hurt performance. It achieves this through Coral, a latency-optimized hierarchical indexing infrastructure based on a novel abstraction called a distributed sloppy hash table, or DSHT.
Histone H3K56 Acetylation, CAF1, and Rtt106 Coordinate Nucleosome Assembly and Stability of Advancing Replication Forks

Chromatin assembly mutants accumulate recombinogenic DNA damage and are sensitive to genotoxic agents. Here we have analyzed why impairment of the H3K56 acetylation-dependent CAF1 and Rtt106 chromatin assembly pathways, which have redundant roles in H3/H4 deposition during DNA replication, leads to genetic instability. We show that the absence of H3K56 acetylation or the simultaneous knock out of CAF1 and Rtt106 increases homologous recombination by affecting the integrity of advancing replication forks, while they have a minor effect on stalled replication fork stability in response to the replication inhibitor hydroxyurea. This defect in replication fork integrity is not due to defective checkpoints. In contrast, H3K56 acetylation protects against replicative DNA damaging agents by DNA repair/tolerance mechanisms that do not require CAF1/Rtt106 and are likely subsequent to the process of replication-coupled nucleosome deposition. We propose that the tight connection between DNA synthesis and histone deposition during DNA replication mediated by H3K56ac/CAF1/Rtt106 provides a mechanism for the stabilization of advancing replication forks and the maintenance of genome integrity, while H3K56 acetylation has an additional, CAF1/Rtt106-independent function in the response to replicative DNA damage.
The role of leptin in the control of insulin-glucose axis

Obesity and diabetes mellitus are great public health concerns throughout the world because of their increasing incidence and prevalence. Leptin, the adipocyte hormone, is well known for its role in the regulation of food intake and energy expenditure. In addition to the regulation of appetite and satiety that recently has attracted much attentions, insight has also been gained into the critical role of leptin in the control of the insulin-glucose axis, peripheral glucose and insulin responsiveness. Since the discovery of leptin, leptin has been taken for its therapeutic potential to obesity and diabetes. Recently, the therapeutic effects of central leptin gene therapy have been reported in insulin-deficient diabetes in obesity animal models such as ob/ob mise, diet-induced obese mice, and insulin-deficient type 1 diabetes mice, and also in patients with inactivating mutations in the leptin gene. Herein, we review the role of leptin in regulating feeding behavior and glucose metabolism and also the therapeutic potential of leptin in obesity and diabetes mellitus.
Tolerance and Reduction of Chromium(VI) by Bacillus sp. MNU16 Isolated from Contaminated Coal Mining Soil

The bacterium MNU16 was isolated from contaminated soils of coal mine and subsequently screened for different plant growth promoting (PGP) activities. The isolate was further identified by 16S rRNA sequencing as Bacillus subtilis MNU16 with IAA concentration (56.95 ± 0.43 6μg/ml), siderophore unit (9.73 ± 2.05%), phosphate solubilization (285.13 ± 1.05 μg/ml) and ACC deaminase activity (116.79 ± 0.019 μmoles α-ketobutyrate/mg/24 h). Further, to evaluate the metal resistance profile of bacterium, the isolate was screened for multi-metal resistance (viz. 900 mg/L for Cr, 600 mg/L for As, 700 mg/L for Ni and 300 mg/L for Hg). Additionally, the resistance pattern of B. subtilis MNU16 against Cr(VI) (from 50 to 300 mg/L) treatments were evaluated. An enriched population was observed at 0–200 mg/L Cr(VI) concentration while slight reductions were observed at 250 and 300 mg/L Cr(VI). Further, the chromium reduction ability at 50 mg/L of Cr(VI) highlighted that the bacterium B. subtilis MNU16 reduced 75% of Cr(VI) to 13.23 mg/L within 72 h. The localization of electron dense precipitates was observed in the TEM images of B. subtilis MNU16 which is might be due to the reduction of Cr(VI) to Cr(III). The data of fluorescence microscopy and flow cytometry with respect to Cr(VI) treatments (50–300 mg/L) showed a similar pattern and clearly revealed the less toxic effect of hexavalent chromium upto 200 mg/L Cr(VI) concentration. However, toxicity effects were more pronounced at 300 mg/L Cr(VI). Therefore, the present study suggests that the plant growth promoting potential and resistance efficacy of B. subtilis MNU16 will go a long way in developing an effective bioremediation approach for Cr(VI) contaminated soils.
Role of molecular charge and hydrophilicity in regulating the kinetics of crystal growth

The composition of biologic molecules isolated from biominerals suggests that control of mineral growth is linked to biochemical features. Here, we define a systematic relationship between the ability of biomolecules in solution to promote the growth of calcite (CaCO3) and their net negative molecular charge and hydrophilicity. The degree of enhancement depends on peptide composition, but not on peptide sequence. Data analysis shows that this rate enhancement arises from an increase in the kinetic coefficient. We interpret the mechanism of growth enhancement to be a catalytic process whereby biomolecules reduce the magnitude of the diffusive barrier, Ek, by perturbations that displace water molecules. The result is a decrease in the energy barrier for attachment of solutes to the solid phase. This previously unrecognized relationship also rationalizes recently reported data showing acceleration of calcite growth rates over rates measured in the pure system by nanomolar levels of abalone nacre proteins. These findings show that the growth-modifying properties of small model peptides may be scaled up to analyze mineralization processes that are mediated by more complex proteins. We suggest that enhancement of calcite growth may now be estimated a priori from the composition of peptide sequences and the calculated values of hydrophilicity and net molecular charge. This insight may contribute to an improved understanding of diverse systems of biomineralization and design of new synthetic growth modulators.
Psychological staging of pediatric cancer patients and their families

Advances in the treatment of childhood cancer have required a shift in our approach to the patient and family. Previously parents were helped to cope with the inevitable decline of the child's health over a rather short period of time; the child was acutely ill and crisis‐oriented intervention was utilized. Today, the family unit can be helped to maintain normal life amidst intensive medical treatment; the child is acutely ill at times, but also chronically ill, and even well. Crisis intervention is still appropriate, but so is education, ego‐supportive counseling, and insight‐oriented psychotherapy. Psychological staging of pediatrics cancer patients and their families is essential in order to properly anticipate psychological adjustment and plan appropriate interventions. Assessment and staging require a multi‐dimensional perspective including stage of disease, socioeconomic vulnerability, degree of psychopathology, family cohesion, and personal/family history. This article discusses this multi‐dimensional perspective and implications for intervention. Illustrative case material is utilized. Cancer 58:449‐453, 1986.
Multi-document Summarization using Probabilistic Topic-based Network Models

Multi-document summarization has obtained much attention in the research domain of text summarization. In the past, probabilistic topic models and network models have been leveraged to generate summaries. However, previous studies do not investigate different combinations of various topic models and network models. This paper describes an integrated approach considering both probabilistic topic models and network models. Two probabilistic topic models and four network models are investigated. We have conducted experiments to evaluate the effectiveness of the proposed approach with the DUC 2004-2007 datasets and make a systematic comparison between two representative topic models, PLSA and LDA. The results show that the PLSA-based network approach outperforms the TF-IDF baseline on all datasets. Moreover, PLSA has better ROUGE performance than LDA for multi-document summarization.
The action of caffeine on the capacity for muscular work

THE research of which an account is to be given in this article differs in several respects from previouis attempts to determine the influence of caffeine on the capacity for muscular work in man. The method which has been usually employed has been to take a continuous series of ergograms at intervals of two to five minutes and to administer the caffeine either before or at some stage in this continuous series. Such a method gives no adequate means for the determination of any differential action of the drug in the fresh condition and after fatigue has been produced by the performance of a certain amount of work. We have therefore tested the effect of the drug on the work recorded in sets of ergograms separated by intervals of rest so that we have been able to examine not only the influence of the drug at different intervals after its administration, but also its action at the beginning of, and throughout each set of ergograms. In another important respect our work differs from all that previously recorded, in that on the normal or control days we have taken doses of a mixture which we were absolutely unable to distinguish from that containing the caffeine'. In this way we have not only eliminated any possible influence of suggestion, but also the much more important sources of error arising from the sensory stimulation produced by swallowing the drug and from the interest due to the act of taking it. Each experiment was prolonged over a number of days, on some of which a dose of caffeine was taken, and on others a dose of the control. Both the caffeine and control mixtures were in most cases prepared for us by Dr W. E. Dixon for whose kind help in this respect we are very greatly indebted.
Altered Localization of Hybrid Incompatibility Proteins in Drosophila

Abstract Understanding the molecular basis of hybrid incompatibilities is a fundamental pursuit in evolutionary genetics. In crosses between Drosophila melanogaster females and Drosophila simulans males, an interaction between at least three genes is necessary for hybrid male lethality: Hmr mel, Lhr sim, and gfzf sim. Although HMR and LHR physically bind each other and function together in a single complex, the connection between gfzf and either of these proteins remains mysterious. Here, we show that GFZF localizes to many regions of the genome in both D. melanogaster and D. simulans, including at telomeric retrotransposon repeats. We find that GFZF localization at telomeres is significantly different between these two species, reflecting the rapid evolution of telomeric retrotransposon copy number composition between the two species. Next, we show that GFZF and HMR normally do not colocalize in D. melanogaster. In interspecies hybrids, however, HMR shows extensive mis-localization to GFZF sites, thus uncovering a new molecular interaction between these hybrid incompatibility factors. We find that spreading of HMR to GFZF sites requires gfzf sim but not Lhr sim, suggesting distinct roles for these factors in the hybrid incompatibility. Finally, we find that overexpression of HMR and LHR within species is sufficient to mis-localize HMR to GFZF binding sites, indicating that HMR has a natural low affinity for GFZF sites. Together, these studies provide the first insights into the different properties of gfzf between D. melanogaster and D. simulans, and uncover a molecular interaction between gfzf and Hmr in the form of altered protein localization.
Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate

Methylphenidate (MP) is widely used to treat attention deficit hyperactivity disorder (ADHD). Variable number of tandem repeats polymorphisms in the dopamine D4 receptor (D4) gene have been implicated in vulnerability to ADHD and the response to MP. Here we examined the contribution of dopamine D4 receptors (D4Rs) to baseline brain glucose metabolism and to the regional metabolic responses to MP. We compared brain glucose metabolism (measured with micro‐positron emission tomography and [18F]2‐fluoro‐2‐deoxy‐d‐glucose) at baseline and after MP (10 mg/kg, i.p.) administration in mice with genetic deletion of the D4. Images were analyzed using a novel automated image registration procedure. Baseline D4−/− mice had lower metabolism in the prefrontal cortex (PFC) and greater metabolism in the cerebellar vermis (CBV) than D4+/+ and D4+/− mice; when given MP, D4−/− mice increased metabolism in the PFC and decreased it in the CBV, whereas in D4+/+ and D4+/− mice, MP decreased metabolism in the PFC and increased it in the CBV. These findings provide evidence that D4Rs modulate not only the PFC, which may reflect the activation by dopamine of D4Rs located in this region, but also the CBV, which may reflect an indirect modulation as D4Rs are minimally expressed in this region. As individuals with ADHD show structural and/or functional abnormalities in these brain regions, the association of ADHD with D4Rs may reflect its modulation of these brain regions. The differential response to MP as a function of genotype could explain differences in brain functional responses to MP between patients with ADHD and healthy controls and between patients with ADHD with different D4 polymorphisms.
Functional Analysis LRP6 Novel Mutations in Patients with Coronary Artery Disease

Background Genetic architecture of coronary artery disease (CAD) is still to be defined. Since low density lipoprotein receptor-related protein 6 (LRP6) gene play critical roles in Wnt signal transduction which are important for vascular development and endodermis specification, we therefore resequenced it to search for mutations in CAD patients. Methods We systemically sequenced all the exons and promoter region of LRP6 gene in a sample of 380 early onset CAD patients and 380 control subjects in Chinese. Results In total, we identified 5 patient-specific mutations including K82N (two patients), S488Y (one patient), P1066T (two patients), P1206H (two patients) and I1264V (one patient) All these mutations located at the extracellular domain of LRP6 gene. In vitro functional analysis of patient-specific mutations demonstrated that these mutations resulted in a significant reduction in both protein level transporting to cell membrane and downstream Wnt signal activity. Furthermore, we found that LRP6 novel mutations attenuated proliferation and migration of human umbilical vein endothelial cells (HUVECs) when compared with wild type (WT) LRP6. Conclusion Our results demonstrated that these loss-of-function variants might contribute to disease liability in a subset of CAD and defects in Wnt signal activation might be important contributing factors for the onset of CAD.