Miracle-dz/UniFAR-FTUs huggingface dataset:
Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensorimotor conditioning

The basal ganglia have been implicated in motor planning and motor learning. In the study reported here, we directly tested for response plasticity in striatal neurons of macaque monkeys undergoing Pavlovian conditioning. To focus the study, we recorded from the tonically active neurons (TANs) of the striatum, which are known to respond to conditioned sensory stimuli that signal reward delivery and elicit behavioral reactions. The activities of 858 TANs were recorded extracellularly from the striatum in alert behaving macaque monkeys before, during, and after the acquisition of a classical conditioning task. Two monkeys were trained to lick reward juice delivered on a spoon simultaneously with the presentation of a click. Almost no licks were triggered by the cues at the start of training, but by the fifth day more than 90% of licks were triggered, and values were near 100% for the remainder of the 3 week training period. In the striatum, only a small number of TANs responded to the clicks at the start before conditioning (about 17%). During training, the numbers of responding TANs gradually increased, so that by the end of training more than 50– 70% of the TANs recorded (51.3–73.5%) became responsive to the clicks. The responses consisted of a pause in firing that occurred approximately 90 msec after the click and that was in some cells preceded by a brief activation and in most cells was followed by a rebound excitation. Prolonged recordings from single TANs (n = 6) showed that individual TANs can acquire a conditioned response within at least as short a time as 10 min. TANs retained such responsiveness after overtraining, and also after a 4 week intermission in training. When the monkey was trained to receive rewards in relation to a new conditioning stimulus, TANs were capable of switching their sensory response to the new stimulus. Histological reconstruction showed that the TANs that became responsive were broadly distributed in the region of striatum explored, which included the dorsal half to two-thirds of the caudate nucleus and putamen over a large anteroposterior span. We conclude that, during the acquisition of a sensorimotor association, TANs widely distributed through the striatum become responsive to sensory stimuli that induce conditioned behavior. This distributed change in activity could serve to modulate the activity of surrounding projection neurons in the striatum engaged in mediating learned behavior.
Understanding the role of social capital for mental wellbeing among older adults

ABSTRACT Previous research applying quantifiable measurements has established significant positive associations between social capital and mental health in older adults. This study aimed to obtain a deeper understanding of the causal mechanisms of social capital affecting mental wellbeing among older people. The study is based on two independent qualitative data materials collected through two focus group interviews and an open-ended question included in a Finnish population-based postal survey. The findings indicate that informal social contacts such as family members and life-long relationships between friends impact the experienced mental wellbeing among older adults due to shared life events, social support, mutual appreciation and trust, as well as a sense of belonging through common social activities. Hence, this study challenges Putnam's idea of social capital as a collective concept focusing on formal contacts and the benefits on a collective level. In addition, the findings highlight the obstacles specific to older adults in maintaining social networks and participation, which should be considered in order to promote mental health in later life.
Normalization 2.0: A longitudinal analysis of German online campaigns in the national elections 2002–9

This article examines the functional, relational and discursive dimensions of the normalization thesis in one study, for both Web 1.0 and Web 2.0 features, in a longitudinal design. It is based on a quantitative content and structural analysis of German party websites in the national elections between 2002 and 2009. The results show that the normalization thesis holds true in all its dimensions over time and in the Web 2.0 era: parties still focus on the top-down elements of information provision and delivery while interactive options are scarce. The digital divide between parliamentary and non-parliamentary parties has narrowed over time, but remains visible for all online functions in 2009. Moreover, the gap is wider in Web 2.0 than in Web 1.0. Finally, German e-campaigns increasingly reflect those patterns of traditional election coverage that have been held accountable for rising political alienation among the public, i.e. strategic news and extensive negativism.
Letters to the editor: A resistant genre of unrepresented voices

This article examines the letters to editor (LE) genre unique to the Pakistani English newspapers in the post-9/11 socio-political historical context. Bhatia’s (2002) framework of applied genre theory was central to this study of the letters to the editor corpus that focused on textual links, rhetorical structure, and argumentative patterns in the Pakistani LE discourse. The corpus-driven discourse analysis demonstrated diversity in organization patterns, and the juxtaposition of general discussion, references to particular incidents, and personal accounts, exhibiting what Bhatia (2002) calls the ‘seemingly chaotic realities’ of a society in transition. The findings reveal an overwhelming dissatisfaction of the people vis-a-vis life in general, and the government and its seemingly insurmountable distance from Pakistani people, more specifically. The study draws attention to letters to the editor as a resistant genre in public discourse.
Comparative analysis of PCR-based biomarker assay methods for colorectal polyp detection from fecal DNA.

BACKGROUND Aberrantly methylated genes are promising biomarkers for the detection of colon adenomas and colorectal cancers (CRCs). The optimal assay type and specific methylated genes for these assays remain to be determined. METHODS We used genomewide microarray-based assays to identify methylated genes as candidate biomarkers for colon neoplasms. The frequency of aberrant methylation of these genes in primary tumors was assessed with methylation-specific PCR (MSP). The limits of detection and specificities for different types of PCR-based assays were then assessed with the most promising genes identified in this screen. Finally, we assessed the best-performing MSP assay as an early-detection marker using fecal DNA samples. RESULTS ITGA4 [integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)] was identified as a novel gene frequently methylated in CRC. Methylated ITGA4 is present in 75% of colon adenomas (n = 36) and 92% of colon adenocarcinomas (n = 75). Comparison of end point MSP, end point MSP with clamped primers, and quantitative fluorescent MSP (qMSP) approaches revealed that both types of end point MSP assays could routinely detect as little as 70 pg DNA, whereas the qMSP assay could routinely detect as little as 7 pg. A fecal DNA qMSP assay for methylated ITGA4 can detect 69% of individuals with colon adenomas (n = 13) with a diagnostic specificity of 79% (n = 28). CONCLUSIONS Methylated ITGA4 is a promising marker gene for the early detection of colonic neoplasms. qMSP has the lowest limit of detection of the MSP assay types tested, and a qMSP assay that detects methylated ITGA4 has potential as an early-detection assay for colon neoplasms.
Psychological contract and job outcomes: mediating role of affective commitment

This cross sectional field survey examined the relationship between psychological contracts, affective commitment and job outcomes (Job satisfaction and Intention to quit). We hypothesized that psychological contract types are related to job satisfaction and turnover intention, we further hypothesized that the link between psychological contract and outcomes is mediated by affective commitment. The data were collected from 302 employees of several public and private organizations of Pakistan. Results revealed that affective commitment mediates the relationship between relational contracts and job satisfaction and the relationship between relational contracts and turnover intention, whereas it does not mediates the relationship between transactional contract and job outcomes. Key words: Psychological contracts, affective commitment, job satisfaction, turnover intention.
Teacher involvement in curriculum design: need for support to enhance teachers’ design expertise

Teacher involvement in curriculum design has a long tradition. However, although it fosters implementation of curriculum reforms, teachers encounter various problems while designing related to conditions set for the design process, and lack the knowledge and skills needed to enact collaborative design processes. Providing support to enhance teachers’ design expertise is essential, since most teachers are novice designers. However, little is known about the nature of the support offered to improve teachers’ design expertise. In this explorative study, six teachers and six facilitators offering support reflected on an enacted design process, the problems they experienced and the support offered. The findings indicate three gaps in teachers’ design expertise related to three domains (1) curriculum design expertise, (2) pedagogical content knowledge and (3) curricular consistency expertise. The outcomes of this study illustrate the importance of supporting teacher designers during the design process and enhancing teachers’ design expertise. By offering (tailored) support to teachers, the enacted design process and the quality of the design materials are expected to improve.
Transthoracic echocardiographic assessment of proximal ascending aorta elasticity in familial heterozygous hypercholesterolemia patients.

BACKGROUND Decreased elasticity of the aorta is associated with aging and several risk factors of atherosclerosis. The data regarding this phenomenon in patients with familial hypercholesterolemia are rather sparse. OBJECTIVES To evaluate non-invasively the elasticity of the proximal ascending aorta of 51 heterozygous FH patients compared to 42 normal age and gender-matched controls. METHODS Aortic elasticity was estimated by transthoracic echocardiography using the "pressure-strain" elastic modulus and aortic strain formulas. RESULTS The elastic modulus score was higher in the FH group than in the controls (1.12 +/- 0.91 10(6) dynes/cm2 vs. 0.65 +/- 0.46 10(6) dynes/cm2 respectively, P = 0.01). This was consistent in both the pediatric (0.5 +/- 0.2 10(6) dynes/cm2 vs. 0.4 +/- 0.1 10(6) dynes/cm2 respectively, P = 0.009) and adult subgroups (1.3 +/- 1.0 10(6) dynes/cm2 vs. 0.8 +/- 0.5 10(6) dynes/cm2 respectively, P = 0.0004). Aortic strain was significantly lower in patients with FH than in controls (6 +/- 4% vs. 9 +/- 5% respectively, P = 0.0002). These findings reflected decreased elasticity of the proximal ascending aorta in the FH patients. In multivariate analysis, age, serum cholesterol level and serum triglycerides level were the independent predictors of the elastic modulus score, whereas age was the predictor of aortic strain. CONCLUSIONS The elasticity of the proximal ascending aorta is decreased in heterozygous FH patients.
Pick's Disease: A Clinical, Computed Tomographic, and Histologic Study With Golgi Impregnation Observations

• We studied a case of pathologically confirmed Pick's disease. Several of the clinical and computed tomographic (CT) features may be helpful in making an in vivo diagnosis of the disease. In addition, the Golgi impregnation studies showed a unique dendritic histopathologic pattern not previously encountered in any of the degenerative dementias.
Aiming for the singing teacher: An applied study on preservice kindergarten teachers’ singing skills development within a music methods course

This study examined the effects of a music methods course offered at a Cypriot university on the singing skills of 33 female preservice kindergarten teachers. To systematically measure and analyze student progress, the research design was both experimental and descriptive. As an applied study which was carried out in situ, the normal procedures of the course were not altered. The methods course incorporated singing instruction in 24 lectures and two 10-minute private singing tutorials at the beginning and middle of the semester. Students’ singing ability was measured before and after the course with a Singing Skills Assessment which required pitch matching and whole-song singing tasks. At the onset of the course 52% of participants could not echo sing accurately la-sol-mi patterns, 58% made several melodic mistakes when singing the criterion songs and only 36% could sing above A4. T test comparisons showed that by the end of the semester participants improved their singing skills significantly in the areas of pitch-matching melodic fragments (p < .001), singing simple children’s songs (p < .001), and highest pitch (p < .001). It is proposed that music methods instructors include some private vocal tuition in their courses, in addition to learning children’s songs, training in melodic patterns and simple vocal exercises.
Task Condition and Pupillometry

While eye tracking is gaining popularity in IS research, pupillometry is relatively less explored in IS eye tracking studies. Research however suggests that pupillometry may serve as an excellent unobtrusive measure to study user information processing behavior. The Adaptive decision making theory asserts that task demand affects information processing behavior. Grounded in this theory, we argue that users’ pupillary responses will be different under different task conditions (task demand). We tested our assertion via an eye tracking laboratory experiment. Our results show that pupillary responses were significantly different under different task conditions. and
You are who you know: inferring user profiles in online social networks

Online social networks are now a popular way for users to connect, express themselves, and share content. Users in today's online social networks often post a profile, consisting of attributes like geographic location, interests, and schools attended. Such profile information is used on the sites as a basis for grouping users, for sharing content, and for suggesting users who may benefit from interaction. However, in practice, not all users provide these attributes. In this paper, we ask the question: given attributes for some fraction of the users in an online social network, can we infer the attributes of the remaining users? In other words, can the attributes of users, in combination with the social network graph, be used to predict the attributes of another user in the network? To answer this question, we gather fine-grained data from two social networks and try to infer user profile attributes. We find that users with common attributes are more likely to be friends and often form dense communities, and we propose a method of inferring user attributes that is inspired by previous approaches to detecting communities in social networks. Our results show that certain user attributes can be inferred with high accuracy when given information on as little as 20% of the users.
c-Jun N-terminal kinase inhibitor favors transforming growth factor-β to antagonize hepatitis B virus X protein-induced cell growth promotion in hepatocellular carcinoma

Transforming growth factor (TGF)-β induces cell growth arrest in well-differentiated hepatocellular carcinoma (HCC) while hepatitis B virus X protein (HBx) minimizes the tumor suppression of TGF-β signaling in early chronic hepatitis B. However, how to reverse the oncogenic effect of HBx and sustain the tumor-suppressive action of TGF-β has yet to be investigated. The present study examined the effect of TGF-β and a c-Jun N-terminal kinase (JNK) inhibitor on cell growth in HCC cells with forced expression of HBx. It was found that HBx promoted cell growth via activation of the JNK/pSMAD3L pathway and inhibition of the transforming growth factor-beta type I receptor (TβRI)/pSMAD3C pathway. pSMAD3L/SMAD4 and pSMAD3C/SMAD4 complexes antagonized each other to regulate c-Myc expression. In the absence of HBx, TGF-β induced cell growth arrest through activation of the TβRI/pSMAD3C pathway in well-differentiated HCC cells. In the presence of HBx, TGF-β had no effect on cell growth. JNK inhibitor SP600125 significantly reversed the oncogenic action of HBx and favored TGF-β to regain the ability to inhibit the cell growth in HBx-expressing well-differentiated HCC cells. In conclusion, targeting JNK signaling favors TGF-β to block HBx-induced cell growth promotion in well-differentiated HCC cells. As an adjunct to anti-viral therapy, the combination of TGF-β and inhibition of JNK signaling is a potential therapy for HBV-infected HCC.
Similarity Measures

With complex multimedia data, we see the emergence of database systems in which the fundamental operation is similarity assessment. Before database issues can be addressed, it is necessary to give a definition of similarity as an operation. We develop a similarity measure, based on fuzzy logic, that exhibits several features that match experimental findings in humans. The model is dubbed fuzzy feature contrast (FFC) and is an extension to a more general domain of the feature contrast model due to Tversky (1977). We show how the FFC model can be used to model similarity assessment from fuzzy judgment of properties, and we address the use of fuzzy measures to deal with dependencies among the properties.
The Big Five in Context: Personality, Diversity and Attitudes toward Equal Opportunities for Immigrants in Switzerland

The paper analyzes the link between personality traits and attitudes of Swiss citizens toward equal opportunities for immigrants. In particular, we examine the extent to which this relationship is moderated by the socio-structural context. We test the assumption that the direct links between personality traits and attitudes toward equal opportunities are strengthened by perceived ethnic diversity. Based on our empirical analyses, we are able to replicate central findings of the research on personality traits and attitudes toward immigrants for the Swiss context. While openness toward experience and agreeableness are positively related to a preference for equal opportunities, conscientiousness is negatively linked to these attitudes. Furthermore, our results reveal that the link between conscientiousness and attitudes toward equal opportunities is significantly moderated by the perceived share of foreigners in the neighborhood. This finding is especially relevant for future research on the effects of personality traits.
Empowerment and mental health in community: narratives of psychiatric consumer/survivors

This paper clarifies the concepts of empowerment and mental health and examines their inter- relationships in a qualitative study of psychiatric consumer/survivors participating in three innovative community mental health programmes. Focus group interviews with 59 stakeholders and in-depth stories of six consumer/survivors served as the data base. We defined mental health as the development of choice, control, and community integration and the acquisition of valued resources, and our research identified indicators of each of these qualities. Moreover, we found empowering processes at the micro, meso, and macro levels of analysis that facilitated the recovery of mental health, as well as disempowering processes that impeded mental health. The findings are discussed in the context of the literature on innovative practices and the emergence of an alternative paradigm in community mental health. Copyright © 2001 John Wiley & Sons, Ltd.
Unranked Tree Algebra

If in a transformation semigroup we assume that the set being acted upon has a semigroup structure, then the transformation semigroup can be used to recognize languages of unranked trees. This observation allows us to examine the relationship connecting languages of unranked trees with standard algebraic concepts such as aperiodicity, idempotency, commutativity and wreath product. In particular, we give algebraic characterizations of first-order logic, chain logic, CTL* and PDL. These do not, however, yield decidability results.
Effect of Molecular Size on the Ability of Zwitterionic Polysaccharides to Stimulate Cellular Immunity1

The large-molecular-sized zwitterionic capsular polysaccharide of the anaerobe Bacteroides fragilis NCTC 9343, designated polysaccharide (PS) A, stimulates T cell proliferation in vitro and induces T cell-dependent protection against abscess formation in vivo. In the present study, we utilized a modification of a recently developed ozonolytic method for depolymerizing polysaccharides to examine the influence of the molecular size of PS A on cell-mediated immunity. Ozonolysis successfully depolymerized PS A into structurally intact fragments. PS A with average molecular sizes of 129.0 (native), 77.8, 46.9, and 17.1 kDa stimulated CD4+-cell proliferation in vitro to the same degree, whereas the 5.0-kDa fragment was much less stimulatory than the control 129.0-kDa PS A. Rats treated with 129.0-kDa, 46.9-kDa, and 17.1-kDa PS A molecules, but not those treated with the 5.0-kDa molecule, were protected against intraabdominal abscesses induced by challenge with viable B. fragilis. These results demonstrate that a zwitterionic polysaccharide as small as 22 repeating units (88 monosaccharides) elicits a T cell-dependent immune response. These findings clearly distinguish zwitterionic T cell-dependent polysaccharides from T cell-independent polysaccharides and give evidence of the existence of a novel mechanism for a polysaccharide-induced immune response.
Ethnic Conflict and the Rise and Fall of Ethnic Newspapers

Contemporary research on collective action claims that organizations play a central role in facilitating many kinds of collective actions. We reverse the causal link and ask whether ethnic conflict affects the life chances of social movement organizations. We analyze the effects of ethnic conflict,fluctuations in the economy, and organizational density on the rates offounding andfailure of white immigrant and African-American newspaper organizations in a system ofAmerican cities, and in New York and Chicago, in the late nineteenth and early twentieth centuries. Our results indicate that hostility and violence encouraged white immigrants to found ethnic newspapers, whereas racial attacks significantly deterred the founding of African-American newspapers. Existing immigrant newspapers thrived under attack, whereas African-American newspapers did not. Thus, the results suggest that the consequences of repressive attacks on ethnic and racial communities depend on the levels of collective violence in addition to the resources controlled by the victimized group.
The Campus Alberta Applied Psychology Counselling Initiative: Web-Based Delivery of a Graduate Professional Training Program

SUMMARY The Campus Alberta Applied Psychology: Counselling Initiative is a collaboration between three universities in western Canada to offer a predominantly Web-based Master of Counselling program. This paper describes the basic structure of the program, the Web-based delivery system, communication tools employed, and the philosophical, pedagogical, programmatic, and administrative principles and concepts foundation to the development and implementation. Development of curricular content and learning processes have been driven by explicit examination of learner needs, a program-level competency matrix reflective of professional practice standards in the discipline of psychology, and deliberate and continuous formative evaluation and learner engagement in the process.