Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence and Management of Primary Malignant Small Bowel Cancers: A Well-defined French Population Study

BACKGROUND AND AIM:Few data are available from population-based statistics on small bowel cancers. The aim of this study was to report on their incidence and management.METHODS:Data were obtained from the population-based Digestive Cancer Registry of Burgundy over a 26-yr period. Incidence rates were calculated by gender, age group, histological type, and 5-yr period. Treatment and stage at diagnosis were investigated. Prognosis was determined using crude and relative survival rates. A multivariate relative survival analysis was performed.RESULTS:Age-standardized incidence rates were 1.2/100,000 inhabitants for men and 0.8/100,000 inhabitants for women. The mean 5-yr variation in incidence were, respectively, +46.7% (P < 0.01) and + 53.2% (P < 0.05). There were four main histological types: adenocarcinoma (40.4%), malignant endocrine tumors (30.5%), lymphoma (20.1%), and sarcoma (9.0%). Resection for cure was performed in 56.6% of the cases. Cancer was not extending beyond the organ in 33.2% of the cases, was associated with lymph node metastasis in 32.1%, and with distant metastasis or unresectability in 34.7%. The 5-yr relative survival rate was 37.4%. It varied between 56.8% for endocrine tumors and 17.8% for sarcoma. In the multivariate analysis, age, histology, and stage at diagnosis significantly influenced the prognosis.CONCLUSIONS:Small bowel cancers represent a heterogeneous group of rare tumors. Prognosis at a population level is worse than in hospital series. In the short term, new therapeutic possibilities represent the best way to improve prognosis.
Activation of the Unfolded Protein Response by 2-Deoxy-d-Glucose Inhibits Kaposi's Sarcoma-Associated Herpesvirus Replication and Gene Expression

ABSTRACT Lytic replication of the Kaposi's sarcoma-associated herpesvirus (KSHV) is essential for the maintenance of both the infected state and characteristic angiogenic phenotype of Kaposi's sarcoma and thus represents a desirable therapeutic target. During the peak of herpesvirus lytic replication, viral glycoproteins are mass produced in the endoplasmic reticulum (ER). Normally, this leads to ER stress which, through an unfolded protein response (UPR), triggers phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α), resulting in inhibition of protein synthesis to maintain ER and cellular homeostasis. However, in order to replicate, herpesviruses have acquired the ability to prevent eIF2α phosphorylation. Here we show that clinically achievable nontoxic doses of the glucose analog 2-deoxy-d-glucose (2-DG) stimulate ER stress, thereby shutting down eIF2α and inhibiting KSHV and murine herpesvirus 68 replication and KSHV reactivation from latency. Viral cascade genes that are involved in reactivation, including the master transactivator (RTA) gene, glycoprotein B, K8.1, and angiogenesis-regulating genes are markedly decreased with 2-DG treatment. Overall, our data suggest that activation of UPR by 2-DG elicits an early antiviral response via eIF2α inactivation, which impairs protein synthesis required to drive viral replication and oncogenesis. Thus, induction of ER stress by 2-DG provides a new antiherpesviral strategy that may be applicable to other viruses.
Low lung volume alters contractile properties of airway smooth muscle in sheep

Breathing at volumes lower than functional residual capacity (FRC) can induce changes in nonasthmatic airways consistent with the behaviour of asthmatic airways. This study investigated the chronic effect of breathing at volumes lower than FRC on the contractility of airway smooth muscle and myosin light chain kinase (MLCK) content and activity. Sheep of three age groups (neonate, adolescent and adult) had their FRC reduced by ∼25% for 4 weeks using a leather corset. Contractile responses to carbachol were then recorded in isolated tracheal strips and bronchial rings. MLCK content and activity were assessed by immunoblotting. The rate of stress generation increased in the bronchial smooth muscle of both adult and adolescent but not neonatal corseted sheep: adolescent corseted versus control, 65.0±4.1 versus 103.4±7.0 s (to reach 50% maximum stress), respectively; and adult corseted versus control, 57.0±6.4 versus 93.4±8.2 s, respectively. This was not due to increases in either bronchial or tracheal smooth muscle amount or MLCK content and activity. The present results indicate that chronic breathing at low lung volumes increases the rate of stress generation in airway smooth muscle.
Endovascular Management of Stroke Patients with Large Vessel Occlusion and Minor Stroke Symptoms

Endovascular mechanical thrombectomy for stroke patients with large vessel occlusion (LVO) in the anterior circulation has become the standard of care based on several major randomized clinical trials. The successful result reported by these trials constitutes what may be the largest achievement in the history of neurological sciences. However, most of these mechanical thrombectomy trials (except for the multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands, i.e., MR CLEAN and Extending the Time for Thrombolysis in Emergency Neurological Deficits–Intra-Arterial, i.e., EXTEND-IA) excluded stroke patients with minor to mild stroke symptoms with National Institutes of Health Stroke Scale (NIHSS) scores of six to eight or lower. The median NIHSS score for patients who underwent acute endovascular thrombectomy was approximately 15 to 17 in all trials. To date, the evidence is lacking to support the mechanical thrombectomy in patients with acute stroke and LVO with minor to mild severity on NIHSS score. The purpose of this review was to assess the current data, safety and clinical outcomes in stroke patients with minor to mild symptoms who were treated with endovascular thrombectomy.
IgG antibodies against microorganisms and atopic disease in Danish adults: the Copenhagen Allergy Study.

BACKGROUND Seropositivity to food-borne and orofecal microorganisms (hepatitis A virus, Helicobacter pylori, and Toxoplasma gondii ), which are considered to be markers of poor hygiene, has been reported to be associated with a lower prevalence of atopy. In contrast, colonization of the gut with Clostridium difficile, a potential intestinal bacterial pathogen, in early childhood may be associated with a higher prevalence of atopy. OBJECTIVE The objective of this study was to investigate the association between atopy and exposure to 2 groups of food-borne and orofecal microorganisms: (1) markers of a poor hygiene and (2) intestinal bacterial pathogens. METHODS A cross-sectional population-based study of 15- to 69-year-olds living in Copenhagen, Denmark, was carried out in 1990 to 1991. Atopy was defined as a positive test result for specific IgE to at least 1 of 6 inhalant allergens. Exposure to microorganisms was assessed as IgG seropositivity to microorganisms. RESULTS Seropositivity to 2 or 3 markers of poor hygiene (hepatitis A virus, H pylori, and T gondii ) was associated with a lower prevalence of atopy (adjusted odds ratio, 0.5; 95% CI, 0.3 to 0.8). In contrast, seropositivity to 2 or 3 intestinal bacterial pathogens (C difficile, Campylobacter jejuni, and Yersinia enterocolitica ) was associated with a higher prevalence of atopy (adjusted odds ratio, 1.7; 95% CI, 1.2 to 2.6). CONCLUSION Exposure to markers of poor hygiene was associated with a lower prevalence of atopy, whereas exposure to intestinal bacterial pathogens was associated with a higher prevalence of atopy. These findings raise the hypothesis that different groups of food-borne and orofecal microorganisms may have different effects on the risk of atopy.
Holds as gestural correlates to empty and filled speech pauses

Holds are deﬁned as an active conﬁgured gestural state where no intended (hand) motion is perceived. We analyzed the audio and video from a cartoon story telling from memo-ry, in order to determine the extent to which gestural holds overlap with speech phenomena such as empty and ﬁlled pauses. Data from two female participants are analyzed: an Italian and an American English-speaker, each using her own native language. The results show a general trend where, in both the languages, holds and speech pauses appear to be correlated. These overlap 28 (cid:0) of the time in the Italian and 45 (cid:0) of the time in the English. There are, however, signiﬁcant differences between the two speakers in the percentage of empty pauses, ﬁlled pauses and holds. The Italian sub-ject uses signiﬁcantlymore gestures, more ﬁlled pauses, and fewer empty pauses than the American subject.
Term Structure Evidence on Interest Rate Smoothing and Monetary Policy Inertia

Numerous studies have used quarterly data to estimate monetary policy rules or reaction functions that appear to exhibit a very slow partial adjustment of the policy interest rate. The conventional wisdom asserts that this gradual adjustment reflects a policy inertia or interest rate smoothing behavior by central banks. However, such quarterly monetary policy inertia would imply a large amount of forecastable variation in interest rates at horizons of more than three months, which is contradicted by evidence from the term structure of interest rates. The illusion of monetary policy inertia evident in the estimated policy rules likely reflects the persistent shocks that central banks face.
Black holes in short period X-ray binaries and the transition to radiatively inefficient accretion

By comparing the orbital period distributions of black hole and neutron star low mass X-ray binaries (LMXBs) in the Ritter-Kolb catalogue (Ritter & Kolb 2003) we show that there is statistical evidence for a dearth of black hole systems at short orbital periods (Porb 3. This could be achieved by a genuine drop in luminosity or through abrupt spectral changes that shift the accretion power out of a given X-ray band.
Energy Management Improvement of Hybrid Electric Vehicles via Combined GPS/Rule-Based Methodology

This paper aims at proposing an efficient and versatile application of Petri nets (PNs) either alone without global positioning system (GPS) as in (GPS-free) system or together with the navigation system (GPS-registered) to conveniently provide a proper energy management strategy for hybrid electric vehicles (HEVs) of high hybridization level and serial architecture. A comparison between the PN strategy and two fuzzy logic strategies is performed in terms of fuel consumption and convergence time. In this paper, short and long trip types of 30 km mainly urban and 240 km mostly highway are considered with an initial state of charge (SoC) of 50% and different daily driving cycles or various standard the New York City Cycle, the New European Driving Cycle, US06 driving cycles. Both kinds of battery management strategies, GPS-free and GPS registered, are demonstrated and compared through simulation studies using the MTCsim software. Dealing with both types of trips, the simulation results significantly illustrate the superiority of the novel GPS-registered methodology’s efficiency toward improving the HEV’s energy management and reducing its fuel consumption besides the relative economic feasibility and structural simplicity features. Over one week duration, the GPS allows reaching the desired final SoC with acceptable errors and reducing the fuel consumption for both daily short and weekend long trips. The originality of this paper is proposing a hybrid GPS/rule-based approach to reduce the fuel consumption during daily driving trips that present about half of the professional travels in 2008 according to the French Sustainable Development Division. This novel strategy is developed on the basis of the recorded GPS data from past trips and the batteries’ final recharging capacities.
Trichinella spiralis and Trichinella pseudospiralis: developmental patterns of enzymes involved in thymidylate biosynthesis and pyrimidine salvage

Thymidylate synthase, dihydrofolate reductase and dUTPase specific activities were found to remain at a high and constant level in crude extracts from adult worms of Trichinella spiralis, as well as from muscle larvae of both Trichinella spiralis (isolated 1–24 months after infection) and Trichinella pseudospiralis (isolated 5·5–13 months after infection). The results obtained with Trichinella pseudospiralis muscle larvae isolated with the use of pepsin did not differ from those obtained when pepsin was not used. No thymidine kinase activity could be detected in muscle larvae of either species and thymidine phosphorylase could be found only in T. pseudospiralis larvae isolated without the use of pepsin. Muscle larvae of both species contained orotidylate phosphoribosyl transferase activity, pointing to a possibility of 5-fluorouracil activation. Uridine phosphorylase, another enzyme involved in 5-fluorouracil anabolism, was also present in T. pseudospiralis muscle larvae. Results of comparative studies on inhibition of purified T. spiralis and rat thymidylate synthases by substrate (4-thio-5-fluoro-dUMP, 2-thio-5-fluoro-dCMP and N4-hydroxy-dCMP) and cofactor (ZD 9331) analogues indicated only dUMP analogues to show feeble selectivity towards the parasite enzyme. A hypothesis is discussed, assuming high expression of thymidylate synthase in muscle larvae to be connected with their cells being arrested in the cell cycle.
Experimental Design and Analysis in Software Engineering: Types of Experimental Design

It is useful to know and understand the several types of designs that you are likely to use in software engineering research, since the type of design constrains the type of analysis that can be performed and therefore the types of conclusions that can be drawn. (A description of these analysis techniques can be found in [Kitchenham 1992].) For example, there are several ways to calculate the F-statistic for an analysis of variance; the choice of calculation depends on the experimental design, including the number of variables and the way in which the subjects are grouped and balanced. Similarly, the measurement scale of the variables constrains the analysis. Nominal scales simply divide data into categories and can be analyzed by using statistical tests such as the Sign test (which looks at the direction of a score or measurement); on the other hand, ordinal scales permit rank ordering and can be investigated with more powerful tests such as Wilcoxon (looking at the size of the measurement differences). Parametric tests such as analysis of variance can be used only on data that is at least of an interval scale.
Soil and plant factors influencing the accumulation of heavy metals by plants.

The use of plants to monitor heavy metal pollution in the terrestrial environment must be based on a cognizance of the complicated, integrated effects of pollutant source and soil-plant variables. To be detectable in plants, pollutant sources must significantly increase the plant available metal concentration in soil. The major factor governing metal availability to plants in soils is the solubility of the metal associated with the solid phase, since in order for root uptake to occur, a soluble species must exist adjacent to the root membrane for some finite period. The rate of release and form of this soluble species will have a strong influence on the rate and extent of uptake and, perhaps, mobility and toxicity in the plant and consuming animals. The factors influencing solubility and form of available metal species in soil vary widely geographically and include the concentration and chemical form of the element entering soil, soil properties (endogenous metal concentration, mineralogy, particle size distribution), and soil processes (e.g., mineral weathering, microbial activity), as these influence the kinetics of sorption reactions, metal concentration in solution and the form of soluble and insoluble chemical species. The plant root represents the first barrier to the selective accumulation of ions present in soil solution. Uptake and kinetic data for nutrient ions and chemically related nonnutrient analogs suggest that metabolic processes associated with root absorption of nutrients regulate both the affinity and rate of absorption of specific nonnutrient ions. Detailed kinetic studies of Ni, Cd, and Tl uptake by intact plants demonstrate multiphasic root absorption processes over a broad concentration range, and the use of transport mechanisms in place for the nutrient ions Cu, Zn, and K. Advantages and limitations of higher plants as indicators of increased levels of metal pollution are discussed in terms of these soil and plant phenomena.
Specific tolerance to neural allografts induced with an antibody to the interleukin 2 receptor

Despite considerable evidence documenting the central nervous system as a site of immunological privilege, immune responses do occur within the brain and neural allografts between major histocompatibility complexes (MHC) and minor antigen incompatible rat strains may be rejected. The survival of completely MHC incompatible neural allografts has been found to be prolonged indefinitely after administration of a monoclonal antibody (mAb) to the interleukin 2 receptor (IL-2R) for 10 d after transplantation. Here we present evidence that rats with long-term surviving lateral ventricular neural allografts, after anti-IL-2R treatment, accept subsequent neural allografts from the same donor strain, placed in a peripheral nonprivileged site, but rapidly reject third-party grafts. Thus, treatment with a mAb to the p55 chain of the IL-2R has resulted in the specific acceptance of second grafts of fully allogeneic neural tissue. These results suggest that ongoing interaction between elements of the host immune system and alloantigen within the brain maintains the tolerant state and furthermore, that interruption of signaling through the IL-2R may be important in allospecific tolerance induction.
Permeability of the human red cell to labelled glucose

The permeability of the human red cell has been much studied particularly by the indirect photo-electric method of Orskov (1935). The results ofsuch experiments have shown that the permeability of the cell membrane is passive in that movement always occurs down the concentration gradient, but that the movement does not obey simple diffusion laws (for reviews see LeFevre, 1954; Wilbrandt, 1954; Bowyer, 1957. Thus, for example, the entry of glucose into the red cell is retarded as the internal concentration rises to a far greater extent than would be expected for diffusion. To explain these phenomena various hypotheses depending on the presence of specific carriers have been put forward (Widdas, 1951, 1952, 1953, 1954; Wilbrandt & Rosenberg, 1951; LeFevre & LeFevre, 1952; Rosenberg & Wilbrandt, 1955). To gain some further insight into the mechanism of glucose transport it was decided to make some attempt to measure the flux of isotopically labelled glucose molecules. A preliminary account of some of the results has already been given (Britton, 1956). More recently LeFevre & McGiniss (1960) have reported some measurements obtained by using an essentially similar technique.
A report on the misdiagnosis of HIV status

s identified and screened at first level (n=841) Abstracts screened at seconds screened at second level (n=292) Records excluded (n=549) Studies assessed for eligibility (n=269) Studies excluded (n=225) because: Describes individual assay performance characteristics or compare characteristics across
Evaluation of Blueberry Juice in Mouse Azoxymethane-Induced Aberrant Crypts and Oxidative Damage

Blueberry is a plant with a number of nutritional and biomedical capabilities. In the present study we initially evaluated the capacity of its juice (BJ) to inhibit the number of aberrant crypts (AC) induced with azoxymethane (AOM) in mouse. BJ was administered daily by the oral route to three groups of animals during four weeks (1.6, 4.1, and 15.0 μL/g), respectively, while AOM (10 mg/kg) was intraperitoneally injected to the mentioned groups, twice a week, in weeks two and three of the assay. We also included two control groups of mice, one administered distilled water and the other the high dose of BJ. A significant increase of AC was observed in the AOM treated animals, and a mean protection of 75.6% was determined with the two low doses of BJ tested; however, the high dose of the juice administered together with AOM increased the number of crypts more than four times the value observed in animals administered only AOM. Furthermore, we determined the antioxidant potential of BJ with an ex vivo DPPH assay and found a dose-dependent decrease with a mean of 19.5%. We also determined the DNA oxidation/antioxidation by identifying 8-hydroxy-2′-deoxyguanosine adducts and found a mean decrease of 44.3% with the BJ administration with respect to the level induced by AOM. Our results show a complex differential effect of BJ related to the tested doses, opening the need to further evaluate a number of factors so as to determine the possibility of a cocarcinogenic potential.
A 10-s Sprint Performed After Moderate-Intensity Exercise Neither Increases nor Decreases the Glucose Requirement to Prevent Late-Onset Hypoglycemia in Individuals With Type 1 Diabetes

OBJECTIVE To determine whether performing a 10-s sprint after moderate-intensity exercise increases the amount of carbohydrate required to maintain euglycemia and prevent late-onset postexercise hypoglycemia relative to moderate-intensity exercise alone. RESEARCH DESIGN AND METHODS Seven individuals with type 1 diabetes underwent a hyperinsulinemic-euglycemic clamp and performed 30 min of moderate-intensity exercise on two separate occasions followed by either a 10-s maximal sprint effort or no sprint. During the following 8 h, glucose infusion rate to maintain euglycemia and rates of glucose appearance and disappearance were measured continuously. RESULTS In response to exercise and throughout the 8-h recovery period, there were no differences in glucose infusion rate, blood glucose levels, plasma insulin concentrations, and rates of glucose appearance and disappearance between the two experimental conditions (P > 0.05). CONCLUSIONS A 10-s sprint performed after 30 min of moderate-intensity exercise does not affect the amount of carbohydrate required to maintain euglycemia postexercise in individuals with type 1 diabetes.