Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk Factors Associated with Anthracycline Induced Cardiac Dysfunction in Pediatric Patients

Anthracyclines (i.e., doxorubicin, daunorubicin) have significant impact on outcome in many pediatric chemotherapy protocols and therefore remain the mainstay of treatment. The objective of this study was to identify the risk factors for anthracycline induced cardiac dysfunction in pediatric patients. Multiple logistic regression model was applied to assess the risk factors for development of cardiac dysfunction. 110 pediatric oncology patients were available for final analysis. 75 (66%) children were males and mean age was 74 ± 44 months. ALL (n = 70, 64%) was the most common primary diagnosis followed by lymphoma (n = 19; 17%) and AML (n = 12, 11%). Daunorubicin alone or in combination with doxorubicin was used in (n = 94, 85%) patients and cumulative dose n = 95; 86%) children. 24 (22%) children received radiation therapy as per protocol and sepsis were observed in 47 (43%) cases. Post anthracycline, 15 (14%) children had cardiac dysfunction within a month; out of them 10/15 (67%) had isolated diastolic dysfunction, while 28 (25%) developed dysfunction within a year. 19 (17%) had pericardial effusion. 11 expired and out of them, 7 had significant cardiac dysfunction. Cumulative dose > 300 mg/m2 (p p = 0.009; AOR 3.5) and sepsis (p = 0.002; AOR 2.6) were found to be independent risk factors associated anthracycline induced cardiac dysfunction. At univariant level use of daunorubicin alone or in combination therapy (p p 0.048, OR 9.7) were also found statistically significant. In conclusion anthracycline induced cardiac dysfunction is mostly related to cumulative dose > 300 mg/m2, use of Daunorubicin alone or in combination with doxorubicin, mode of delivery, radiation therapy and sepsis. Regular long term follow-up with cardiologist is the key point for early diagnosis and therapy for a long term survival.
Music and People with Tendencies to Depression

Depression is often associated with a reduced motivation to engage in behavior that will improve one’s mood. This paper presents a study in which 175 university students listened to a self-selected piece of music on Youtube that made them sad. Post- and pre-listening scores of depressed mood on the Profile of Mood States (POMS) were taken, as were measures of rumination and scores on the Like Sad Music Scale (LSMS). Results indicate that listening to sad music via this medium can significantly increase feelings of depression in people with a tendency to depression (as suggested by high rumination scores). Furthermore, people with a tendency to depression demonstrate a liking for such music despite the potentially unhealthy consequences of listening to it.
Using cooperative education and work-integrated education to provide career clarification

When students commence university studies they typically choose subjects that are of interest to them, and hold only vague notions of intended career paths. However, some universities offer work-integrated learning degrees (WIL), programs that require students to undertake relevant practical work experience by way of work placements, internships or sandwich degrees. The underlying notion of these degrees is that learning occurs, as Lave and Wenger (1991) argue, by way of legitimate peripheral participation, where the student as the ‘newcomer’ works alongside a practising expert (the ‘old timer’). As the student becomes more engaged with workplace practices, he or she begins to learn workplace norms by way of mediated action and situated learning. These workplace norms include things such as the use of workplace-specific language, and particular methodological techniques unique to that workplace (Eames & Cates, 2011). Past research has shown that work placements can greatly enhance career clarification for students (Dressler & Keeling, 2011), and that students gradually become enculturated into a community of practice. Recent research in our group suggests that WIL programs also allow the development greater awareness of career paths. This research indicates, for example, that for some students work placements provide clarity about skills and qualifications needed to become a research scientist – subsequently providing motivation to complete graduate studies. Several OECD reports highlight the need for more PhD level scientists and engineers, and we argue here that WIL programs provide a career clarification that is more convincing than any amount of career counselling.
Effects of Teacher Self-Monitoring on Implementation of Curriculum-Based Measurement and Mathematics Computation Achievement of Students with Disabilities

This study examined the effects of combining curriculum-based measurement in mathematics computation with teachers' self-monitoring of instructional changes on academic progress of elementary students with learning disabilities and mild mental disabilities. Participating teachers were assigned to a control group that did not use curriculum-based measurement, a curriculum-based measurement-only group, or a curriculum-based measurement with self-monitoring group. In the curriculum-based measurement group, teachers assessed their students' progress by administering, graphing, and analyzing short, biweekly probes. Teachers in the curriculum-based measurement with self-monitoring group also used this monitoring system; in addition, they used a self-monitoring procedure that was structured to guide them in analyzing student progress and the instructional plan they had been using with an individual student. Results indicated that teachers who self-monitored their use of curriculum-based measurement revised their students' instructional plans in ways that differed significantly from those of teachers who did not self-monitor all parts of curriculum-based measurement. Additionally, the combination of curriculum-based measurement and self-monitoring resulted in significantly greater growth for students.
Cardiomyogenesis in the Adult Human Heart

Rationale: The ability of the human heart to regenerate large quantities of myocytes remains controversial, and the extent of myocyte renewal claimed by different laboratories varies from none to nearly 20% per year. Objective: To address this issue, we examined the percentage of myocytes, endothelial cells, and fibroblasts labeled by iododeoxyuridine in postmortem samples obtained from cancer patients who received the thymidine analog for therapeutic purposes. Additionally, the potential contribution of DNA repair, polyploidy, and cell fusion to the measurement of myocyte regeneration was determined. Methods and Results: The fraction of myocytes labeled by iododeoxyuridine ranged from 2.5% to 46%, and similar values were found in fibroblasts and endothelial cells. An average 22%, 20%, and 13% new myocytes, fibroblasts, and endothelial cells were generated per year, suggesting that the lifespan of these cells was approximately 4.5, 5, and 8 years, respectively. The newly formed cardiac cells showed a fully differentiated adult phenotype and did not express the senescence-associated protein p16INK4a. Moreover, measurements by confocal microscopy and flow cytometry documented that the human heart is composed predominantly of myocytes with 2n diploid DNA content and that tetraploid and octaploid nuclei constitute only a small fraction of the parenchymal cell pool. Importantly, DNA repair, ploidy formation, and cell fusion were not implicated in the assessment of myocyte regeneration. Conclusions: Our findings indicate that the human heart has a significant growth reserve and replaces its myocyte and nonmyocyte compartment several times during the course of life.
Comments on “Reflections on ‘A Review of Trends in Serious Gaming’”

In large measure the authors agree with Tobias and Fletcher’s (2012) comments stating that clearer operational definitions of game features are needed to enable research on games and learning. The authors cannot accept that games are a subset of simulations, preferring to identify instances when games and simulations overlap and when they do not. The authors caution that research focused solely on cognitive processes risks missing fundamental environmental dynamics and their rich interactions with the intentional dynamics of situated cognition. The authors point out that their specific review of games and academic achievement is complemented by the broader survey of dependent variables reviewed by Tobias and Fletcher.
Disturbances of sensation in children with hemiplegia.

Major attention has properly been directed at the motor handicap in hemiplegia, but the frequent coexistence of mental defect and convulsions is also well known. The possibilities of significant sensory impairment and of visual defects, however, while well known as a feature of cerebral vascular accidents among adults, have received scant attention in connection with the long-term management of hemiplegia in childhood and young adult life. The standard pediatric, orthopedic, and neurological textbooks largely ignore the subject, which has received only infrequent and relatively recent mention in medical periodicals. Bender 1 mentions its frequency among adult hemiplegics, especially if tested by the extinction method, and a brief preliminary report of our study has already been presented. 2 Detailed testing of sensation and visual fields of hemiplegic children presents technical difficulties, which have doubtless in part accounted for inattention to such features in the past. The difficulties are not insurmountable, however,
The mass of the white dwarf in the recurrent nova U Scorpii

ABSTRA C T We present spectroscopy of the eclipsing recurrent nova U Sco. The radial velocity semi- amplitude of the primary star was found to be KWa 93 ^ 10 km s 21 from the motion of the wings of the He II l4686-Aemission line. By detecting weak absorption features from the secondary star, we find its radial velocity semi-amplitude to be KRa 170 ^ 10 km s 21 . From these parameters, we obtain a mass of M1a 1:55 ^ 0:24 M( for the white dwarf primary star and a mass of M2a 0:88 ^ 0:17 M( for the secondary star. The radius of the secondary is calculated to be R2a 2:1 ^ 0: 2R (, confirming that it is evolved. The inclination of the system is calculated to be ia 828 7 ^ 28 9, consistent with the deep eclipse seen in the light- curves. The helium emission lines are double-peaked, with the blueshifted regions of the disc being eclipsed prior to the redshifted regions, clearly indicating the presence of an accretion disc. The high mass of the white dwarf is consistent with the thermonuclear runaway model of recurrent nova outbursts, and confirms that U Sco is the best Type Ia supernova progenitor currently known. We predict that U Sco is likely to explode within ,700 000 yr.
Climate change induced transformations of agricultural systems: insights from a global model

Climate change might impact crop yields considerably and anticipated transformations of agricultural systems are needed in the coming decades to sustain affordable food provision. However, decision-making on transformational shifts in agricultural systems is plagued by uncertainties concerning the nature and geography of climate change, its impacts, and adequate responses. Locking agricultural systems into inadequate transformations costly to adjust is a significant risk and this acts as an incentive to delay action. It is crucial to gain insight into how much transformation is required from agricultural systems, how robust such strategies are, and how we can defuse the associated challenge for decision-making. While implementing a definition related to large changes in resource use into a global impact assessment modelling framework, we find transformational adaptations to be required of agricultural systems in most regions by 2050s in order to cope with climate change. However, these transformations widely differ across climate change scenarios: uncertainties in large-scale development of irrigation span in all continents from 2030s on, and affect two-thirds of regions by 2050s. Meanwhile, significant but uncertain reduction of major agricultural areas affects the Northern Hemisphere’s temperate latitudes, while increases to non-agricultural zones could be large but uncertain in one-third of regions. To help reducing the associated challenge for decision-making, we propose a methodology exploring which, when, where and why transformations could be required and uncertain, by means of scenario analysis.
Adapting Tests To the Cultural Setting

AFRICA has been the scene of much testing research but few testing programs. The data in Wickert’s (1960) survey, in the reports of individual countries (CCTA, 1960), and in Biesheuvel’s (1962) questionnaire study show that throughout tropical Africa little applied testing is done. This can be partly ascribed to the administrative problems of introducing and operating large-scale selection or guidance procedures. But the basic limitation has been the state of the art. For
The effects of primed causal uncertainty and causal importance on persuasion

We examined the effects of temporarily accessible causal uncertainty and causal importance on persuasion. Participants completed a scrambled sentence priming task, read strong or weak, causal or noncausal arguments, and then reported their attitudes. We found that participants primed with high levels of causal uncertainty and importance thought carefully about the causal arguments. They were more persuaded by the strong compared to weak causal arguments, and this effect was partially mediated by the favorability of their message-relevant thoughts. Participants primed with high causal uncertainty and low causal importance were more persuaded by strong compared to weak noncausal arguments, but this effect was not mediated by thoughts. We discuss the implications of these findings for the causal uncertainty and persuasion literatures.
Payment for Results: Effects of the Kentucky and Maryland Group-Based Performance Award Programs

The research reported in this article was supported by Grant 97001184000 from the Pew Charitable Trusts and the U.S. Department of Education, Office of Educational Research and Improvement, National Institute of Educational Goverance, Finance, Policy-Making and Management, to the Consortium for Policy Research in Education (CPRE) and the Wisconsin Center for Education Research, School of Education, University of Wisconsin-Madison (Grant OERI-R3086A60003). The opinions expressed are those of the authors and do not necessarily reflect the view of the Pew Charitable Trusts, the National Institute on Educational Governance, Finance, Policy-Making and Management, Office of Educational Research and Improvement, U.S. Department of Education, the institutional partners of CPRE, or the Wisconsin Center for Education Research. We thank Tom Hruz, Jason Hanna, and Sal Castillo for their research assistance.
Retrospective spiritual narratives: exploring recalled childhood and adolescent spiritual experiences

This paper draws on a collection of retrospective narratives of childhood and adolescent spiritual experiences to explore the qualities and characteristics of the spirituality of the young. They recall a range of spiritual experiences that touch on death, mortality, visions, and perceptions and connections beyond the self. Their experiences include varying intensities of emotion and invoke a range of responses in them and others. The paper considers the social, emotional and familial context of these early life experiences and their impact on spiritual experience and the possibility/impossibility and freedom/lack of freedom to express, and integrate spirituality.
A Person-Centered Approach to Multicultural Counseling Competence

This article examines current and historical trends in psychotherapy research and practice with racial/ethnic minority populations. Initially, research on Derald Sue’s multicultural counseling competencies is provided as a foundation to further examine the evidence regarding effective cultural adaptations to mainstream treatment approaches, such as cognitive-behavior therapy and interpersonal psychotherapy. Next, a brief outline of Carl Rogers’s psychotherapy research tradition is presented, with a focus on both past and present evidence suggesting that person-centered therapy may be effective across diagnoses, as well as cultures. Using psychotherapy evidence from both the latter half of the 20th century and the initial decades of the 21st century, cultural adaptations to previously hypothesized person-centered therapy mechanisms of change are proposed. In particular, this culturally adapted person-centered approach is suggested to provide a competent and effective treatment system for racial/ethnic minority clients and families.
Affective, Motivational and Behavioural Outcomes from an Exercise Intervention Comparing Self-Selected versus Imposed Intensity

Understanding the factors that will lead individuals to increase and maintain their levels of physical activity is a key area of investigation within exercise psychology. Research has suggested that the affective responses that individuals experience during exercise may have a role in predicting future exercise behaviour (Kiviniemi, Voss-Humke & Seifert, 2007; Williams, Dunsiger, Ciccolo, Lewis, Albrecht & Marcus, 2008). Thus, it is important to ensure individuals experience positive exercise-induced affective responses. Both exercise intensity and the method of exercise prescription are factors that have been shown to influence exercise-induced affective responses. For example, self-selected intensities have been shown to result in more positive and less variable affective responses than exercise imposed at the same intensity (e.g., Rose & Parfitt, 2007). However, the extent to which a self-selected versus imposed intensity method of prescription influences exercise motivation and behaviour has not been examined in a longitudinal investigation. The purpose of the current research was to compare the affective responses to exercise, levels of self-determined motivation and physical activity behaviour that results from a six-week intervention of selfselected versus imposed intensity exercise. A single-subject multiple baseline case design was used to identify individual differences in exercise preference and affective responses and gain in-depth information on the cognitive appraisal process and behavioural outcomes without losing external validity. Six females aged 39-49 years participated in a six week intervention consisting of 30 min of aerobic exercise three times a week. Three participants exercised at a self-selected intensity and three at an imposed intensity based on the relative intensity they self-selected at baseline. Affect, self-determined motivation, self-efficacy and physical activity behaviour were measured weekly throughout the intervention and six weeks post-intervention. The results showed that, as expected, the intensities chosen between participants were variable. Participants in the imposed condition selected intensities that were below their Ventilatory Threshold (VT) at baseline. Participants in the self-selected group selected a mixture of intensities (one below, one at, and one above VT). As expected, two of the three participants in the imposed condition had less positive affective responses during the intervention, while in the self-selected condition affect remained positive throughout the intervention despite higher intensities being selected. Participants in both conditions increased their physical activity behaviour to the same extent from baseline to follow up. Perceived
Reactivation of Lytic Replication from B Cells Latently Infected with Epstein-Barr Virus Occurs with High S-Phase Cyclin-Dependent Kinase Activity while Inhibiting Cellular DNA Replication

ABSTRACT Productive infection and replication of herpesviruses usually occurs in growth-arrested cells, but there has been no direct evidence in the case of Epstein-Barr virus (EBV), since an efficient lytic replication system without external stimuli does not exist for the virus. Expression of the EBV lytic-switch transactivator BZLF1 protein in EBV-negative epithelial tumor cell lines, however, is known to arrest the cell cycle in G0/G1 by induction of the tumor suppressor protein p53 and the cyclin-dependent kinase (CDK) inhibitors p21WAF-1/CIP-1 and p27KIP-1, followed by the accumulation of a hypophosphorylated form of the Rb protein. In order to determine the effect of the onset of lytic viral replication on cellular events in latently EBV-infected B LCLs, a tightly controlled induction system of the EBV lytic-replication program by inducible BZLF1 protein expression was established in B95-8 cells. The induction of lytic replication completely arrested cell cycle progression and cellular DNA replication. Surprisingly, the levels of p53, p21WAF-1/CIP-1, and p27KIP-1 were constant before and after induction of the lytic program, indicating that the cell cycle arrest induced by the lytic program is not mediated through p53 and the CDK inhibitors. Furthermore, although cellular DNA replication was blocked, elevation of cyclin E/A expression and accumulation of hyperphosphorylated forms of Rb protein were observed, a post-G1/S phase characteristic of cells. Thus, while the EBV lytic program promoted specific cell cycle-associated activities involved in the progression from G1 to S phase, it inhibited cellular DNA synthesis. Such cellular conditions appear to especially favor viral lytic replication.
Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas

The BRCA/RAD51 complex of tumor suppressor genes plays a major role in the DNA damage response. In this explorative study, BRCA1, BRCA2, and RAD51 mRNA expression was quantified in highly defined laser microdissected tissue samples of simple adenomas, adenocarcinomas of the mammary gland, and their lymph node metastases by real-time quantitative reverse transcription polymerase chain reaction. Expression levels in the tumors were normalized to the geometric mean of 3 housekeeping genes and quantified relative to normal mammary epithelium of the same dog. In adenomas, mRNA expression was reduced for BRCA1 (6/10 dogs, 60%), BRCA2 (4/10 dogs, 40%), and RAD51 (4/10, 40%). In adenocarcinomas BRCA1 expression varied with increased expression in 3 of 10 (30%) dogs and no differences in 7 of 10 (70%) dogs when compared with normal mammary gland. BRCA2 and RAD51 were overexpressed in 5 of 10 (50%) and 6 of 10 (60%) of adenocarcinomas, respectively. An overexpression of RAD51 and BRCA2 was found in 8 of 10 (80%) and 5 of 10 (50%) of the lymph node metastases, respectively. Direct comparison of primary tumors and metastases revealed increased mRNA expression of BRCA1 (2/10 dogs, 20%), BRCA2 (2/10 dogs, 20%), and RAD51 (3/10 dogs, 30%) in lymph node metastases. Taken together, the results suggest that RAD51 is upregulated in the majority of lymph node metastases of canine mammary tumors. Further experimental studies are needed to clarify whether these changes in gene expression are a direct carcinogenetic stimulus or a protective response due to genetic instability during tumor progression.