Miracle-dz/UniFAR-FTUs huggingface dataset:
Fine particulate matter air pollution and cognitive function among U.S. older adults.

OBJECTIVES There is growing interest in understanding how exposures in the residential environment relate to cognitive function in older adults. The goal of this study is to determine if neighborhood-level exposure to fine particulate matter air pollution (PM2.5) is associated with cognitive function in a diverse, national sample of older U.S. adults. METHODS We use cross-sectional data on non-Hispanic black and white men and women aged 55 and older from the 2001/2002 Americans' Changing Lives Study (N = 780). EPA air monitoring data were linked to respondents using census tract identifiers. Cognitive function was assessed with tests of working memory and orientation. Negative binomial regression models were used to examine the association between PM2.5 and the number of errors on the cognitive assessment. RESULTS Older adults living in areas with high concentrations of PM2.5 had an error rate 1.5 times greater than those exposed to lower concentrations, net of individual and neighborhood-level demographic and socioeconomic characteristics. DISCUSSION This study adds to a growing body of research demonstrating the importance of air pollution to cognitive function in older adults. Improvements to air quality may be an important mechanism for reducing age-related cognitive decline.
Sleep as a Mediator of Screen Time Effects on US Children's Health Outcomes

There is growing concern regarding the influence of media exposure on American children's health and development. The current prospective study tested the direct relations between media exposure, sleep, and various health outcomes (e.g. attention problems, aggression, and body composition) and the indirect effect of media exposure through sleep disturbances. Child participants (N = 1,317) completed measures of media consumption and sleep. Teachers reported on children's attention problems and use of physical aggression. Results showed that media exposure at Time 1 was indirectly related to attention, physical aggression, and Body Mass Index at Time 3 (13 months later), mediated by sleep at Time 2. Overall, these results support the hypothesis that screen time is negatively related to health outcomes, and that displaced sleep is one of the mediating mechanisms underlying these relations.
Study of the brain mechanisms involved in the learning and processing of high-level mathematical concepts

How does the human brain conceptualize abstract ideas? In particular, what is the origin of mathematical activity, especially when it is associated with high-level of abstraction? Is mathematical thought independent of language? Cognitive science has now started to investigate this question that has been of great interest to philosophers, mathematicians and educators for a long time. While studies have so far focused on basic arithmetic processing, my PhD thesis aims at further investigating the cerebral processes involved in the manipulation and learning of more advanced mathematical ideas. I have shown that (1) advanced mathematical reflection on concepts mastered for many years does not recruit the brain circuits for language; (2) mathematical activity systematically involves number- and space-related brain regions, regardless of mathematical domain, problem difficulty, and participants' visual experience; (3) non-verbal acquisition of geometrical rules relies on a language of thought that is independent of natural spoken language. Finally, altogether these results raise new questions and pave the way to further investigations in neuroscience: - is the human ability for language also irrelevant to advanced mathematical acquisition in schools where knowledge is taught verbally? - What is the operational definition of the fields of “mathematics” and “language” at the brain level?
Gender differences in left ventricle geometry and function in patients undergoing balloon dilatation of the aortic valve for isolated aortic stenosis. NHLBI Balloon Valvuloplasty Registry.

BACKGROUND--Gender differences in cardiac size have been described in normal humans and animals and in response to pressure overload. To examine the influence of gender on the left ventricular response to pressure overload, clinical, haemodynamic, and echocardiographic data were analysed in the 232 adults with isolated aortic stenosis enrolled in the Balloon Valvuloplasty Registry. METHODS AND RESULTS--There were 92 men (mean (SD) age 75 (11) years) and 140 women (79 (9) years; P = 0.002). Women had similar symptoms (New York Heart Association class) but lower overall functional status than men (P = 0.008). Catheterisation data showed similar valve area indices (mean (SD) (0.30 (0.09) in men and 0.31 (0.13) cm/m2 in women) but higher peak and mean gradients in women (peak 74 (30) v 63 (22) mm Hg; mean 61 (21) v 54 (18) mm Hg; both P < or = 0.01). On M mode echocardiography women had greater septal and posterior wall thickness but similar cavity diameter, after normalising dimensions to body surface area, resulting in higher relative wall thickness (0.60 (0.20) v 0.50 (0.15); P = 0.0002). Left ventricular mass index was similar in women and men (166 (59) v 159 (50) gm/m2 respectively), however, the prevalence of left ventricular hypertrophy according to sex specific criteria was 54% in men and 81% in women (P = 0.0001). Multiple logistic regression models that adjusted for age, functional status, fractional shortening, and left ventricular systolic pressure found the presence or absence of hypertrophy to be independently associated with gender (P < or = 0.002). Left ventricular systolic function tended to be better in women, who had a higher cardiac index (2.5 (0.8) v 2.3 (0.6) 1/min/m2; P = 0.01), left ventricular peak systolic pressure (211 (36) v 192 (35) mm Hg; P = 0.0001), and echo fractional shortening (32 (13) v 28 (12)%; P = 0.05); however, these differences were reduced when patients with regional wall motion abnormalities were excluded. CONCLUSIONS--In this population of elderly patients undergoing balloon dilatation of isolated aortic stenosis, left ventricular chamber geometry was different in men and women. Because this was a selected population, gender should be further evaluated as a possible determinant of the cardiac adaptation to chronic pressure overload.
Advanced Electrical Machines and Machine-Based Systems for Electric and Hybrid Vehicles

The paper presents a number of advanced solutions on electric machines and machine-based systems for the powertrain of electric vehicles (EVs). Two types of systems are considered, namely the drive systems designated to the EV propulsion and the power split devices utilized in the popular series-parallel hybrid electric vehicle architecture. After reviewing the main requirements for the electric drive systems, the paper illustrates advanced electric machine topologies, including a stator permanent magnet (stator-PM) motor, a hybrid-excitation motor, a flux memory motor and a redundant motor structure. Then, it illustrates advanced electric drive systems, such as the magnetic-geared in-wheel drive and the integrated starter generator (ISG). Finally, three machine-based implementations of the power split devices are expounded, built up around the dual-rotor PM machine, the dual-stator PM brushless machine and the magnetic-geared dual-rotor machine. As a conclusion, the development trends in the field of electric machines and machine-based systems for EVs are summarized.
Scale-Space Derived From B-Splines

This paper proposes a scale-space theory based on B-spline kernels. Our aim is twofold: 1) present a general framework, and show how B-splines provide a flexible tool to design various scale-space representations. In particular, we focus on the design of continuous scale-space and dyadic scale-space frame representations. A general algorithm is presented for fast implementation of continuous scale-space at rational scales. In the dyadic case, efficient frame algorithms are derived using B-spline techniques to analyze the geometry of an image. The relationship between several scale-space approaches is explored. The behavior of edge models, the properties of completeness, causality, and other properties in such a scale-space representation are examined in the framework of B-splines. It is shown that, besides the good properties inherited from the Gaussian kernel, the B-spline derived scale-space exhibits many advantages for modeling visual mechanism including the efficiency, compactness, orientation feature and parallel structure.
Do Transaction Costs of Payment Systems Differ Across Customers in E-commerce?

Cost-efficient processing and low working capital requirements are highly important for online retailers’ competitiveness and profitability. Therein, a sound understanding of transaction costs of respective payment instruments is extremely relevant when deciding which payment method to offer in ecommerce. Using a unique dataset with more than 14 million actual sales transactions from a leading European online retailer, this paper investigates the effect of customers’ characteristics on retailers’ transaction costs. In order to evaluate the payment choice of online retailers, the authors empirically derive cost schedules of the payment instruments invoice, credit card, PayPal and prepayment as a function of the transaction size. The results reveal extensive differences in the transaction costs and the collection time of accounts receivables across payment methods and customers. From a managerial perspective, this study illustrates how retailers can develop an efficient payment provision strategy on a customized basis with regard to low transaction costs and capital requirements.
Three-loop Three-Linear Vertices and Four-Loop m̃om β functions in massless QCD

In this paper we present a full set of 2and 3-point functions for massless QCD at three-loop order in the ms scheme. The vertex functions are evaluated at the asymmetric point with one vanishing momentum. These results are used to relate the ms coupling constant to that of various momentum subtraction (mom) renormalization schemes at three-loop order. With the help of the known four-loop ms β-function we then determine the four-loop coefficients of the corresponding m̃om β-functions. As an application we consider the momentum dependence (running) of the three-gluon asymmetrical vertex recently computed within the lattice approach by Ph. Boucaud et al. in [1]. An account of the four-loop term in the corresponding β-function leads to a significant (around 30%) decrease of the value of the non-perturbative 1/p correction to the running found in [1]. ∗Permanent address: Institute for Nuclear Research, Russian Academy of Sciences, 60th October Anniversary Prospect 7a, Moscow 117312, Russia.
Apolipoprotein B and non-high density lipoprotein cholesterol and the risk of coronary heart disease in Chinese Published, JLR Papers in Press, August 13, 2007.

The aim of our study was to compare apolipoprotein B (apoB), non-high density lipoprotein cholesterol (nonHDL-C), low density lipoprotein cholesterol (LDL-C), and other lipid markers as predictors of coronary heart disease (CHD) in Chinese. Overall, 122 individuals developed CHD during a median 13.6 years of follow-up in 3,568 adult participants from a community-based cohort. The multivariate relative risk of CHD in the highest quintile compared with the lowest quintile was 2.74 [95% confidence interval (CI), 1.45–5.19] for apoB, 1.98 (95% CI, 1.00–3.92) for nonHDL-C, and 1.86 (95% CI, 1.00–3.49) for LDL-C (all tests for trend, P < 0.05). ApoB also had the highest receiver operator characteristic curve area (0.63; 95% CI, 0.58–0.68) in predicting CHD. When apoB and nonHDL-C were mutually adjusted, only apoB was predictive; the relative risk was 2.80 (95% CI, 1.31–5.96; P = 0.001) compared with 1.09 (95% CI, 0.49–2.40; P = 0.75) for nonHDL-C. Compared with the lowest risk, participants with the highest apoB and total cholesterol/HDL-C had a 3-fold increased risk of developing CHD (relative risk = 3.21; 95% CI, 1.45–7.14). These data provide strong evidence that apoB concentration was a better predictor of CHD than other lipid markers in Chinese.
How may I serve you?: a robot companion approaching a seated person in a helping context

This paper presents the combined results of two studies that investigated how a robot should best approach and place itself relative to a seated human subject. Two live Human Robot Interaction (HRI) trials were performed involving a robot fetching an object that the human had requested, using different approach directions. Results of the trials indicated that most subjects disliked a frontal approach, except for a small minority of females, and most subjects preferred to be approached from either the left or right side, with a small overall preference for a right approach by the robot. Handedness and occupation were not related to these preferences. We discuss the results of the user studies in the context of developing a path planning system for a mobile robot.
SiGe bipolar technologies for low phase noise RF and microwave applications

This paper presents an overview of the low frequency noise performances of both "abrupt" and "gradual" SiGe HBTs. We demonstrated that when appropriate device is used, 1/f corner noise frequency at 1 kHz is obtained. We further presented a correlation with phase noise performances which outperform those reported with III-V devices.
Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants

Objective: Canagliflozin, a sodium-glucose co-transporter 2 inhibitor, approved for the treatment of type-2 diabetes mellitus (T2DM), is metabolized by uridine diphosphate-glucuronosyltransferases (UGT) 1A9 and UGT2B4, and is a substrate of P-glycoprotein (P-gp). Canagliflozin exposures may be affected by coadministration of drugs that induce (e.g., rifampin for UGT) or inhibit (e.g. probenecid for UGT; cyclosporine A for P-gp) these pathways. The primary objective of these three independent studies (single-center, open-label, fixed-sequence) was to evaluate the effects of rifampin (study 1), probenecid (study 2), and cyclosporine A (study 3) on the pharmacokinetics of canagliflozin in healthy participants. Methods: Participants received; in study 1: canagliflozin 300 mg (days 1 and 10), rifampin 600 mg (days 4 – 12); study 2: canagliflozin 300 mg (days 1 – 17), probenecid 500 mg twice daily (days 15 – 17); and study 3: canagliflozin 300 mg (days 1 – 8), cyclosporine A 400 mg (day 8). Pharmacokinetics were assessed at pre-specified intervals on days 1 and 10 (study 1); on days 14 and 17 (study 2), and on days 2 – 8 (study 3). Results: Rifampin decreased the maximum plasma canagliflozin concentration (Cmax) by 28% and its area under the curve (AUC) by 51%. Probenecid increased the Cmax by 13% and the AUC by 21%. Cyclosporine A increased the AUC by 23% but did not affect the Cmax. Conclusion: Coadministration of canagliflozin with rifampin, probenecid, and cyclosporine A was well-tolerated. No clinically meaningful interactions were observed for probenecid or cyclosporine A, while rifampin coadministration modestly reduced canagliflozin plasma concentrations and could necessitate an appropriate monitoring of glycemic control.
The Effects of Tamoxifen and Its Metabolites on Platelet Function and Release of Reactive Oxygen Intermediates

Tamoxifen is effective in the prevention and treatment of breast cancer, but its use is associated with an increased risk of thrombosis. The mechanism for this effect is unknown. Reactive oxygen intermediates enhance platelet-dependent thrombosis, and in oncological studies, tamoxifen has been shown to increase production of reactive oxygen species. Therefore, the effects of tamoxifen and its bioactive metabolites on platelet activity and platelet reactive oxygen species were determined. Platelets were incubated with tamoxifen or the metabolites 4-hydroxy-tamoxifen (4-OH), N-desmethyl tamoxifen, or 4-hydroxy-N-desmethyl tamoxifen (endoxifen). Tamoxifen metabolites have been previously shown to possess enhanced bioactivity, and consistent with this observation, tamoxifen metabolites but not tamoxifen modestly increased platelet aggregation. These effects were similar with platelets isolated from male or female subjects. Platelet nitric oxide release or cGMP levels were not altered by incubation with tamoxifen or any of its metabolites. Incubation with tamoxifen metabolites increased stimulation-dependent platelet superoxide release [8.1 ± 1.6 arbitrary units (a.u.) for control versus 15.2 ± 3.5 a.u. for 4-OH; P < 0.01]. Coincubation with a superoxide dismutase mimetic eliminated the tamoxifen metabolite-induced enhancement of platelet aggregation. Corresponding to increased superoxide release, incubation with tamoxifen metabolites enhanced the functional activation of NADPH oxidase as determined by phosphorylation of its subunits p47phox and p67phox. In summary, incubation of platelets with the active metabolites of tamoxifen increases stimulation-dependent superoxide release through a NADPH oxidase-dependent mechanism. This results in modest changes in platelet function and seems to be consistent with previous oncological studies demonstrating tamoxifen-dependent increase in reactive oxygen species generation.
Cognitive Neuroscience of Aging

The number of reports on the cognitive neuroscience of aging has increased in recent years, and most of these studies have found many similarities in the patterns of activity in young and old adults, indicating that basic neural mechanisms are maintained into older age. Despite these overall similarities, older adults often have less activity in some regions, such as medial temporal areas during memory processing and visual regions across a variety of cognitive domains. It seems clear that age reductions in cognitive function can be tied, at least in part, to these reductions in brain activity. On the other hand, older adults typically also overrecruit some brain areas, mainly the ventral or dorsal prefrontal cortex during memory tasks, as well as both the frontal and parietal regions during tasks engaging cognitive control processes, such as attention. Sometimes this overrecruitment appears to be in response to altered function in other brain regions and is often seen in those older adults who perform better on the task at hand. These findings have provided rather convincing support for the idea that overrecruitment can be compensatory in the elderly. Nevertheless, not all age increases can be interpreted as compensatory, and some are more indicative of neural inefficiency. The challenge facing future research will be to understand the task conditions that promote compensation in older adults, the role of the various brain areas in aiding cognitive function, and how these compensatory mechanisms can be elicited to enhance quality of life in the elderly.
Soft core hyperon - nucleon potentials

A new Nijmegen soft-core OBE potential model is presented for the low-energy YN interactions. Besides the results for the fit to the scattering data, which largely defines the model, we also present some applications to hypernuclear systems using the G-matrix method. The potentials are generated by the exchange of nonets of pseudoscalar, vector, and scalar mesons. As is standard in the Nijmegen soft-core models, we also include the J=0 contributions from the tensor f{sub 2},f{sub 2}',a{sub 2}, and pomeron Regge trajectories, and use Gaussian form factors to guarantee that the potentials have a soft behavior near the origin. An important innovation with respect to the original soft-core potential is the assignment of the cutoff masses for the baryon-baryon-meson (BBM) vertices in accordance with broken SU(3){sub F}, which serves to connect the NN and the YN channels. As a novel feature, we allow for medium strong breaking of the coupling constants, using the {sup 3}P{sub 0} model with a Gel-Mann-Okubo hypercharge breaking for the BBM coupling. Charge-symmetry breaking in the {Lambda}p and {Lambda}n channels is included as well. We present six hyperon-nucleon potentials which describe the available YN cross section data equally well, but which exhibit some differences on a moremore » detailed level. The differences are constructed such that the models encompass a range of scattering lengths in the {Sigma}N and {Lambda}N channels. In all cases, we obtained {chi}{sup 2}/N{sub data}{approx}0.55 for 35 YN data. In particular, we were able to fit the precise experimental datum r{sub R}=0.468{+-}0.010 for the inelastic capture ratio at rest. For the scalar-meson mixing angle we obtained values {theta}{sub s}=37{sup o}-40{sup o}, which points to almost ideal mixing angles for the scalar q{ovr q} states. The G-matrix results indicate that the remarkably different spin-spin terms of the six potentials appear specifically in the energy spectra of {Lambda} hypernuclei. « less
Recognition of facial emotional expressions and its correlation with cognitive abilities in children with Down syndrome.

Down syndrome (DS) is one of the most common chromosomal abnormalities. Delays in cognitive development are found in the first years of life. As years pass, it may turn into intellectual deficiencies that unfold into several aspects, including difficulty recognizing emotional facial expressions. The present study investigated the recognition of six universal facial emotional expressions in a population of children aged 6-11 years who were divided into two groups: DS group and typically developing children (TDC) group. We used the Perception Test of Facial Emotional Expressions (Teste de Percepcao de Emocoes Faciais; TEPEF) and Wechsler Intelligence Scale for Children (WISC-III) and found that children with DS presented alterations in the recognition of expressions of disgust, surprise, and fear, whereas the recognition of happiness, sadness, and anger was maintained at a level comparable to the TDC group. Participants with DS presented significant positive correlations between sadness and Picture completion, Mazes, Arithmetic, Vocabulary, Digits, Verbal IQ, Verbal Comprehension Index, and Working Memory Index. All other facial expressions showed significant negative correlations with the Intelligence Quotient and WISC-III factorial index subtests. Absence of correlations was found among the TEPEF's six facial expressions and Information, Coding, Symbols, and Working Memory Index. The contribution of this study is related to understanding the characteristics of the recognition of facial emotions in children with DS, an important component of social relationships with their peers, schools, and families.