Miracle-dz/UniFAR-FTUs huggingface dataset:
Occupational Noise Annoyance Linked to Depressive Symptoms and Suicidal Ideation: A Result from Nationwide Survey of Korea

Background Noise, or undesirable sound, is one of the most common environmental stressors, and it can cause various health effects. Beyond the auditory consequences of occupational noise exposure, extra-auditory effects such as psychological problems have also been found. The aim of the current study is to elucidate the association between occupational noise annoyance and psychological symptoms, including symptoms of depression and suicidal ideation. Methods A total of 10,020 participants (5,410 men and 4,610 women) were included in the current analysis, using data from the fourth Korean National Health and Nutrition Examination Survey (KNHANES). Self-report questionnaires were used to assess noise annoyance levels, depressive symptoms, and suicidal ideation. Odds ratios (ORs) and 95% confidence intervals (95% CIs) for psychosocial symptoms were calculated using multiple logistic regression models. Results Compared to the no noise annoyance group, ORs (95% CI) of the severe annoyance groups were 1.58 (1.12–2.23) and 1.76 (1.29–2.40) in men and 1.49 (1.05–2.11) and 1.41 (1.01–1.97) in women for depressive symptoms and suicidal ideation, respectively. The ORs (95% CI) for severe noise annoyance in those with less than five hours of sleep were 2.95 (1.46–5.96) and 2.05 (1.01–4.16) in men and women, respectively, compared with those with no noise annoyance and a sleep time of more than five hours. Conclusion Our study shows that occupational noise annoyance is significantly related to mental health, including depressive symptoms and suicidal ideation after controlling for individual and socio-demographic characteristics even with gender stratification. However, prospective studies with quantified noise exposure assessment were needed to elucidate the causality on the association between noise annoyance and psychological symptoms.
Which Events Constitute Criteria A1 of PTSD? The Phenomenology of Psychological Trauma in Youth

The aim of this study was to explore the phenomenology of psychological trauma in youth. It was hypothesized that events reported as traumatic could be classified into one of seventeen trauma categories, that levels of impairment in traumatized youth would be higher than levels of impairment in non-traumatized youth, and that traumatic events reported would be differentially related to Posttraumatic Stress Disorder (PTSD) symptoms and types of cognitive errors. Information regarding traumas and PTSD symptoms was collected through The Child PTSD Checklist from a sample of youth aged 6 to 17. A coding system was developed for classification of traumatic events. The expression symptom and impairment levels were evaluated through parent and child report. The coding system had Cohen’s Kappas ranging from . 78-1.00. Findings indicate that traumatized youth demonstrate higher levels of impairment than non-traumatized youth, and that traumatic events are not differentially related to PTSD symptoms or cognitive errors.
Title Pericentromeric Regions Are Refractory To Prompt Repair after Replication Stress-Induced Breakage in HPV 16 E 6 E 7-Expressing Epithelial Cells

Chromosomal instability is the major form of genomic instability in cancer cells. Amongst various forms of chromosomal instability, pericentromeric or centromeric instability remains particularly poorly understood. In the present study, we found that pericentromeric instability, evidenced by dynamic formation of pericentromeric or centromeric rearrangements, breaks, deletions or iso-chromosomes, was a general phenomenon in human cells immortalized by expression of human papillomavirus type 16 E6 and E7 (HPV16 E6E7). In particular, for the first time, we surprisingly found a dramatic increase in the proportion of pericentromeric chromosomal aberrations relative to total aberrations in HPV16 E6E7-expressing cells 72 h after release from aphidicolin (APH)-induced replication stress, with pericentromeric chromosomal aberrations becoming the predominant type of structural aberrations (,70% of total aberrations). In contrast, pericentromeric aberrations accounted for only about 20% of total aberrations in cells at the end of APH treatment. This increase in relative proportion of pericentromeric aberrations after release from APH treatment revealed that pericentromeric breaks induced by replication stress are refractory to prompt repair in HPV16 E6E7-expressing epithelial cells. Telomerase-immortalized epithelial cells without HPV16 E6E7 expression did not exhibit such preferential pericentromeric instability after release from APH treatment. Cancer development is often associated with replication stress. Since HPV16 E6 and E7 inactivate p53 and Rb, and p53 and Rb pathway defects are common in cancer, our finding that pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing cells may shed light on mechanism of general pericentromeric instability in cancer. Citation: Deng W, Tsao SW, Guan X-Y, Cheung ALM (2012) Pericentromeric Regions Are Refractory To Prompt Repair after Replication Stress-Induced Breakage in HPV16 E6E7-Expressing Epithelial Cells. PLoS ONE 7(10): e48576. doi:10.1371/journal.pone. 0048576 Editor: Kerstin Borgmann, University Medical Center Hamburg-Eppendorf, Germany Received April 18, 2012; Accepted September 26, 2012; Published October 31, 2012 Copyright: 2012 Deng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This study was supported by a grant from The University of Hong Kong, Project No. 201007176014. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: lmcheung@hkucc.hku. hk
Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*.

There is increasing evidence of genetic contribution to the pathogenesis of Parkinson's disease. The identification of mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene has shed new light on genetic variations responsible for autosomal dominantly inherited Parkinson's disease. In this analysis, the most comprehensive published so far, we screened a second large series comprising 53 families with Parkinson's disease for mutations in the LRRK2 gene by direct sequencing to further determine the frequency of the mutation and evaluate the clinical phenotype to establish a genotype/phenotype relation. For comparison, all novel and known mutations were investigated in a cohort of 337 patients with apparently sporadic Parkinson's disease and a cohort of 1200 control subjects using an ABI 7900 Allelic Detection system. We identified 7 more families with LRRK2 variations in the 53 families with Parkinson's disease. Four of these are novel amino acid substitutions (R793M, Q930R, S1096C, S1228T). Because of incomplete penetrance and possible phenocopies pathogenic relevance of the Q930R and S1096C mutations as well as for the previously described A3342G splice site mutation could not be established with certainty. The so far most common mutation (G2019) was not detected in our large cohort. Late onset and typical l-dopa responsive parkinsonian features were generally observed, often accompanied by impairment of executive functions and high interference values in neuropsychological testing, as well as sleeping disturbances but rare hallucinations. There were no abnormalities in electrophysiological investigations. Distinct intrafamily and interfamily differences could be observed, including the clinical presentation of diffuse Lewy body disease in one patient. The frequent finding of cerebral atrophy on MRI and less substantia nigra hyperechogenicity compared with idiopathic Parkinson's disease on transcranial ultrasound needs to be confirmed in further studies. Together with the findings obtained in 46 families in our first study, LRRK2 mutations, therefore, account for 13% of apparently autosomal dominant families in our population with varying but still generally typical clinical presentation of Parkinson's disease.
Human platelet aggregation and shape change are coupled to separate thromboxane A2-prostaglandin H2 receptors.

The relationships of human platelet thromboxane A2-prostaglandin H2 (TxA2/PGH2) receptor occupation as assessed by equilibrium binding of the TxA2/PGH2 agonist [125I]BOP to the functional responses of I-BOP-induced platelet shape change and aggregation were determined before and after specific, irreversible inactivation of platelet TxA2/PGH2 receptors with the photolyzable TxA2/PGH2 antagonist I-PTA-PON3. I-BOP stimulated platelet shape change and aggregation with concentrations producing a half-maximal response of 173 +/- 39 pM (n = 4) and 1.8 +/- 0.4 nM (n = 6), respectively (means +/- SE). Covalent inactivation of TxA2/PGH2 receptors with I-PTA-PON3 caused rightward shifts of I-BOP shape change and aggregation dose-response curves and resulted in pharmacological dissociation constants (Kd) of 134 pM and 1.95 nM, respectively. Isotherms of [125I] BOP binding to intact platelets (n = 6) were shallow with Hill coefficients of -0.68 +/- 0.03 and were best described by a two-site model with 222 +/- 58 sites/platelet of high affinity (Kd = 270 +/- 60 pM) and 818 +/- 90 sites/platelet of lower affinity (Kd = 3.9 +/- 1.2 nM). The relationship of I-BOP occupancy of high-affinity receptors to shape-change responses was linear (r = 0.97, P less than 0.001), but the occupancy-response relationship for the lower affinity receptor and platelet aggregation was hyperbolic with half-maximal aggregation occurring after occupation of 25% of the receptors. After covalent inactivation of a variable proportion of the receptors with I-PTA-PON3, the occupancy-response relationship for platelet aggregation resulted in a similar hyperbola indicating an excess of low-affinity receptors coupled to aggregation (spare receptors). (ABSTRACT TRUNCATED AT 250 WORDS)
The Ferroxidase Activity of Yeast Frataxin*

Frataxin is required for maintenance of normal mitochondrial iron levels and respiration. The mature form of yeast frataxin (mYfh1p) assembles stepwise into a multimer of 840 kDa (α48) that accumulates iron in a water-soluble form. Here, two distinct iron oxidation reactions are shown to take place during the initial assembly step (α → α3). A ferroxidase reaction with a stoichiometry of 2 Fe(II)/O2 is detected at Fe(II)/mYfh1p ratios of ≤0.5. Ferroxidation is progressively overcome by autoxidation at Fe(II)/mYfh1p ratios of >0.5. Gel filtration analysis indicates that an oligomer of mYfh1p, α3, is responsible for both reactions. The observed 2 Fe(II)/O2 stoichiometry implies production of H2O2 during the ferroxidase reaction. However, only a fraction of the expected total H2O2 is detected in solution. Oxidative degradation of mYfh1p during the ferroxidase reaction suggests that most H2O2reacts with the protein. Accordingly, the addition of mYfh1p to a mixture of Fe(II) and H2O2 results in significant attenuation of Fenton chemistry. Multimer assembly is fully inhibited under anaerobic conditions, indicating that mYfh1p is activated by Fe(II) in the presence of O2. This combination induces oligomerization and mYfh1p-catalyzed Fe(II) oxidation, starting a process that ultimately leads to the sequestration of as many as 50 Fe(II)/subunit inside the multimer.
A Demonstration Work Activities Center for Multiply Handicapped, Visually Impaired Persons

We outline training programs for multiply handicapped, visually impaired persons who have historically been served by agencies not geared to address their special needs. A continuum of services designed to meet the living and employment training needs of multiply handicapped, visually impaired persons deemed ineligible for vocational rehabilitation services is presented. The Opportunities Unlimited Work Activities Center program is discussed along with the population it serves and the interagency mechanism around which it is designed.
Comparing Apples to Apples: Why the Net Energy Analysis Community Needs to Adopt the Life-Cycle Analysis Framework

How do we know which energy technologies or resources are worth pursuing and which aren’t? One way to answer that question is to compare the energy return of a certain technology—i.e., how much energy is remaining after accounting for the amount of energy expended in the production and delivery process. Such energy return ratios (the most famous of which is energy return on investment (EROI)) fall within the field of net energy analysis (NEA), and provide an easy way to determine which technology is “better”; i.e., higher Energy Return Ratios (ERRs) are, certeris paribus, better than lower ERRs. Although useful as a broad measure of energy profitability, comparisons can also be misleading, particularly if the units being compared are different. For example, the energy content of electricity produced from a photovoltaic cell is different than the energy content of coal at the mine-mouth, yet these are often compared directly within the literature. These types of inconsistencies are common within the NEA literature. In this paper, we offer life cycle assessment (LCA) and the LCA methodology as a possible solution to the persistent methodological issues within the NEA community, and urge all NEA practitioners to adopt this methodology in the future.
Group-theoretical construction of extended baryon operators in lattice QCD

The design and implementation of large sets of spatially extended, gauge-invariant operators for use in determining the spectrum of baryons in lattice QCD computations are described. Group-theoretical projections onto the irreducible representations of the symmetry group of a cubic spatial lattice are used in all isospin channels. The operators are constructed to maximize overlaps with the low-lying states of interest, while minimizing the number of sources needed in computing the required quark propagators. Issues related to the identification of the spin quantum numbers of the states in the continuum limit are addressed.
Electroweak observables in a general 5D background

Warped extra dimensions provide a new playground to study electroweak brea-king and the nature of the higgs field. In this paper we reanalyze the electroweak observables in theories with one extra dimension and a completely general warp factor. We demonstrate that, regardless of the 5D background, SU(2)R is needed in order to avoid excessive contributions to the T parameter. For higgsless theories cancellations between different contributions to the S parameter are needed.
Evaluation of virological procedures to detect fetal human cytomegalovirus infection: Avidity of IgG antibodies, virus detection in amniotic fluid and maternal serum

Human cytomegalovirus (HCMV) is the most common cause of viral intrauterine infection and fetal damage largely due to maternal primary infection. Virological procedures which are able to detect HCMV fetal infection were evaluated. HCMV IgG antibodies were detected in 62.5% of the pregnant women and 1.47% had a primary infection. From March, 1992 to August, 1995, 29 seroconversions were observed, and in 64 other cases. HCMV IgM antibodies were detected in the first serological test. The mean IgG antibody avidity test (AI) was 31% for the 11 seroconversions tested and 74% in 32 cases where IgG and IgM HCMV antibodies were detected in the first serum. In the 29 HCMV seroconversions, 19 amniocentesis were carried out and 12 fetuses (41.4%) were infected in utero. In four amniotic fluids positive in culture and PCR, the fetus or newborns were infected and in one out of the two cordocentesis undertaken, hepatitis, anemia, and thrombocytopenia were noted. In four other cases, investigations seeking HCMV in amniotic fluid were negative whereas infants were infected at birth. Among the 64 cases with positive HCMV IgM and IgG antibodies detected in the first serological test, three fetuses were infected in utero, but no amniotic fluid was available in these cases. Amniotic fluids were studied in 39 cases, and HCMV detection by culture and PCR‐hybridization was negative. HCMV DNA was detected in the maternal sera of five out of 21 pairs of seroconversions and in two cases on the first negative serum. The assay was also carried out on 50 of the 64 HCMV IgM positive sera. Two had detectable HCMV DNA. © 1996 Wiley‐Liss, Inc.
Music and Mind in Everyday Life

1. Music in people's lives MAKING MUSIC 2. Motivations and skills 3. Expression and communication in performance 4. Improvising and composing USING MUSIC 5. Hearing and listening 6. Individuals using music 7. Groups using music ACQUIRING MUSIC 8. Lifelong musical development 9. Contexts for learning 10. The psychology of music - an overview
The Role of heat shock protein 27 in extravillous trophoblast differentiation

Trophoblast cells from placental explants differentiate in culture to extravillous trophoblast cells (EVT cells). During trophoblast differentiation heat‐shock‐protein‐27 (HSP27) mRNA and multidrug‐resistance‐protein‐5 (MRP5, transporter of cyclic nucleotides) expression are increased. HSP27 is a regulator of actin filaments structure and dynamic, has a role in cell differentiation and may affect NF‐kB activity. In this study we aimed to assess HSP27 level in trophoblast cells and its correlation with motility and differentiation related processes [MMPs activity, nitric oxide (NO), inducible nitric oxide synthase (iNOS), proliferation and MRP5 levels]. We evaluated HSP27 expression in a first trimester human trophoblast explants model designed to assess EVT cells differentiation/migration with/without 6‐mercaptopurine (6MP, an EVT inhibitor of migration). We found that HSP27 level is expressed in the nucleous and cytoplasm of non‐proliferting villous‐trophoblast cells (negative for Ki67) and in the cell periphery and cytoplasm of motile EVT cells. Moreover, 6MP decreased HSP27 nucleous expression that was associated with inhibited MMP2 activity and NO production. Also decreased iNOS expression and increased MRP5 mRNA levels were observed. In conclusion, HSP27 expression is modulated in concordance with migration dependent parameters in trophoblast cells. J. Cell. Biochem. 103: 719–729, 2008. © 2007 Wiley‐Liss, Inc.
Characterisation of visuospatial memory in the Tg2576 model of Alzheimer's disease

Previous behavioural characterization of the Tg2576 mouse has been limited to reference memory tasks in water or T/Y mazes. This thesis aimed to specify the underlying features of visuospatial memory in this model of Alzheimer's disease. Chapter 2 presents a series of experiments that are consistent with the hypothesis that aged Tg2576 animals are impaired in forming allocentric representations of the environment. Experiments 1 and 2 demonstrated that aged transgenic mice were able to acquire a simple room discrimination and contextual conditional left-right discrimination in a T-maze. Experiment 3 showed that aged transgenic mice were able to learn a response strategy in a reference memory task in the plus maze. Tg2576 mice were however significantly impaired in the acquisition of the place version of the plus maze task and T-maze forced-choice alternation (Experiment 2a). Using a spontaneous object recognition paradigm, Experiment 4 revealed that adult mutant mice were able to discriminate between familiar and novel objects with delays of up-to 24 hours and were also able to discriminate the relative familiarity of two objects. However, Tg2576 mice failed to investigate objects that had changed their relative spatial positions. Furthermore, Experiment 5, using an episodic-like memory task, demonstrated that Tg2576 mice were unable to integrate information concerning the temporal properties and spatial location of objects. This inability reflected a primary deficit in processing or memory for the spatial location of objects. Chapter 4 examined the nature of the spatial representations that were impaired by the APPswe mutation in versions of a spontaneous object recognition paradigm. Experiment 6 evaluated Tg2576 mouse habituation. Experiment 8 demonstrated that Tg2576 performance was not facilitated by the presence of an intra maze cue. Experiments 7 and 9 revealed that Tg2576 mice were sensitive to changes in the spatial organisation of the objects when the objects were moved to locations previously unoccupied during the sample stage. This pattern of results suggests that Tg2576 mice manifest a specific deficit in the formation of object-location associations akin to the impairment observed in Alzheimer patients (e.g., Swainson et al., 2001).
Image segmentation and labeling using the Polya urn model

We propose a segmentation method based on Polya's (1931) urn model for contagious phenomena. A preliminary segmentation yields the initial composition of an urn representing the pixel. The resulting urns are then subjected to a modified urn sampling scheme mimicking the development of an infection to yield a segmentation of the image into homogeneous regions. This process is implemented using contagion urn processes and generalizes Polya's scheme by allowing spatial interactions. The composition of the urns is iteratively updated by assuming a spatial Markovian relationship between neighboring pixel labels. The asymptotic behavior of this process is examined and comparisons with simulated annealing and relaxation labeling are presented. Examples of the application of this scheme to the segmentation of synthetic texture images, ultra-wideband synthetic aperture radar (UWB SAR) images and magnetic resonance images (MRI) are provided.
A time pooled track kernel for person identification

We present a novel method for comparing tracks by means of a time pooled track kernel. In contrast to spatial or feature-space pooling, the track kernel pools base kernel results within tracks over time. It includes as special cases frame-wise classification on the one hand and the normalized sum kernel on the other hand. We also investigate non-Mercer instantiations of the track kernel and obtain good results despite its Gram matrices not being positive semidefinite. Second, the track kernel matrices in general require less memory than single frame kernels, allowing to process larger datasets without resorting to subsampling. Finally, the track kernel formulation allows for very fast testing compared to frame-wise classification which is important in settings where user feedback is obtained and quick iterations of re-training and re-testing are required. We apply our approach to the task of video-based person identification in large scale settings and obtain state-of-the art results.
Combined planar and eruptive xanthoma in a patient with type lla hyperlipoproteinemia.

Granuloma annulare‐like histology is a reaction pattern that is generally idiopathic, but has been attributed to a variety of inciting factors. The exact mechanism for this pattern is unknown but existing theories include type IV delayed hypersensitivity, Th1 inflammatory reaction with IFN‐γ‐provoking lymphocytes, lymphocyte‐mediated activation of monocytes, and elastic tissue injury as the primary alteration. [7]