Miracle-dz/UniFAR-FTUs huggingface dataset:
Homeostatic Regulation of Memory Systems and Adaptive Decisions

While it is clear that many brain areas process mnemonic information, understanding how their interactions result in continuously adaptive behaviors has been a challenge. A homeostatic‐regulated prediction model of memory is presented that considers the existence of a single memory system that is based on a multilevel coordinated and integrated network (from cells to neural systems) that determines the extent to which events and outcomes occur as predicted. The “multiple memory systems of the brain” have in common output that signals errors in the prediction of events and/or their outcomes, although these signals differ in terms of what the error signal represents (e.g., hippocampus: context prediction errors vs. midbrain/striatum: reward prediction errors). The prefrontal cortex likely plays a pivotal role in the coordination of prediction analysis within and across prediction brain areas. By virtue of its widespread control and influence, and intrinsic working memory mechanisms. Thus, the prefrontal cortex supports the flexible processing needed to generate adaptive behaviors and predict future outcomes. It is proposed that prefrontal cortex continually and automatically produces adaptive responses according to homeostatic regulatory principles: prefrontal cortex may serve as a controller that is intrinsically driven to maintain in prediction areas an experience‐dependent firing rate set point that ensures adaptive temporally and spatially resolved neural responses to future prediction errors. This same drive by prefrontal cortex may also restore set point firing rates after deviations (i.e. prediction errors) are detected. In this way, prefrontal cortex contributes to reducing uncertainty in prediction systems. An emergent outcome of this homeostatic view may be the flexible and adaptive control that prefrontal cortex is known to implement (i.e. working memory) in the most challenging of situations. Compromise to any of the prediction circuits should result in rigid and suboptimal decision making and memory as seen in addiction and neurological disease. © 2013 The Authors. Hippocampus Published by Wiley Periodicals, Inc.
Discriminative Learning for Joint Template Filling

This paper presents a joint model for template filling, where the goal is to automatically specify the fields of target relations such as seminar announcements or corporate acquisition events. The approach models mention detection, unification and field extraction in a flexible, feature-rich model that allows for joint modeling of interdependencies at all levels and across fields. Such an approach can, for example, learn likely event durations and the fact that start times should come before end times. While the joint inference space is large, we demonstrate effective learning with a Perceptron-style approach that uses simple, greedy beam decoding. Empirical results in two benchmark domains demonstrate consistently strong performance on both mention detection and template filling tasks.
Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes

Aim We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and 7 susceptibility loci originally identified by European genome-wide association study (GWAS) in 2012: ZMIZ1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, and BCAR1. We also examined the association of 3 additional loci: CCND2 and GIPR, identified in sex-differentiated analyses, and LAMA1, which was shown to be associated with non-obese European type 2 diabetes. Methods We genotyped 6,972 Japanese participants (4,280 type 2 diabetes patients and 2,692 controls) for each of the 10 single nucleotide polymorphisms (SNPs): rs12571751 in ZMIZ1, rs10842994 near KLHDC5, rs2796441 near TLE1, rs459193 near ANKRD55, rs10401969 in CILP2, rs12970134 near MC4R, rs7202877 near BCAR1, rs11063069 near CCND2, rs8108269 near GIPR, and rs8090011 in LAMA1 using a multiplex polymerase chain reaction invader assay. The association of each SNP locus with the disease was evaluated using a logistic regression analysis. Results All SNPs examined in this study had the same direction of effect (odds ratio > 1.0, p = 9.77 × 10-4, binomial test), as in the original reports. Among them, rs12571751 in ZMIZ1 was significantly associated with type 2 diabetes [p = 0.0041, odds ratio = 1.123, 95% confidence interval 1.037–1.215, adjusted for sex, age and body mass index (BMI)], but we did not observe significant association of the remaining 9 SNP loci with type 2 diabetes in the present Japanese population (p ≥ 0.005). A genetic risk score, constructed from the sum of risk alleles for the 7 SNP loci identified by un-stratified analyses in the European GWAS meta-analysis were associated with type 2 diabetes in the present Japanese population (p = 2.3 × 10-4, adjusted for sex, age and BMI). Conclusions ZMIZ1 locus has a significant effect on conferring susceptibility to type 2 diabetes also in the Japanese population.
Identification of the Coronal Sources of the Fast Solar Wind

The present spectroscopic study of the ultraviolet coronal emission in a polar hole, detected on 1996 April 6-9 with the Ultraviolet Coronagraph Spectrometer aboard the Solar and Heliospheric Observatory spacecraft, identifies the interplume lanes and background coronal hole regions as the channels in which the fast solar wind is preferentially accelerated. In interplume lanes, at heliocentric distance 1.7 R☉, the corona expands at a rate between 105 and 150 km s-1, that is, much faster than in plumes in which the outflow velocity is between 0 and 65 km s-1. The wind velocity is inferred from the Doppler dimming of the O VI λλ1032, 1037 lines, within a range of values, whose lower and upper limit corresponds to anisotropic and isotropic velocity distribution of the oxygen coronal ions, respectively.
Contribution of Multiple Isolating Barriers to Reproductive Isolation Between a Pair of Phytophagous Ladybird Beetles

Reproductive isolation between species may often be attained by multiple isolating barriers, but the components are rarely studied in animal taxa. To elucidate the nature of multiple isolating barriers, we quantified the strength of three premating barriers, including ecologically based ones (seasonal, habitat, and sexual), two postmating—prehatching barriers (reduced egg hatchability and conspecific sperm precedence [CSP]), and one posthatching barrier, including four components of F1 hybrid reduced fitness, between two phytophagous ladybird beetles, Henosepilachna vigintioctomaculata and H. pustulosa. We detected five positive barriers (habitat isolation, sexual isolation, reduced egg hatchability, CSP, and reduced egg hatchability in backcrosses of F1 hybrids). None of these barriers entirely prevents gene exchange when it acts alone, but jointly they generate nearly complete reproductive isolation even between sympatric populations. Host fidelity contributed most strongly to reproductive isolation by reducing interspecific hybridization through several important types of ecological isolation, including microspatial, habitat, and seasonal isolation. The existence of multiple isolating barriers likely helps keep reproductive isolation stable and robust, by complementing changes in the strength of leaky barriers. This complementarity of multiple isolating barriers yields the concept of robustness of reproductive isolation, which is important when considering the long-term maintenance of species boundaries in coexisting species pairs.
From school to work and from work to school: information environments and transferring information literacy practices

This study aimed to evaluate the extent to which Year 10 students’ information literacy practice in schools was relevant to the workplace information environment (Year 10 students are aged 14). It also aimed to explore whether some workplace information practices might be transferred back into school. In order to meet these aims, the study sought to explore the views of Year 10 students on their information practices in school and at home, as well as their views on workplace information environments, before they went on a 10 day work experience placement. The study then sought the views of these students on school and workplace information environments when they returned from work experience. The views of the students’ guidance teachers were also canvassed via pre- and post-placement interviews. The study took place in Scotland. The school is a state comprehensive secondary school (Years 7-12, ages 11-17) which has 500 students and 64 teachers, and is situated in a town with a population of 7,000. Students at the school come from a range of socio-economic backgrounds. They completed their work experience in a variety of workplace environments, including small commercial businesses, large firms, education, healthcare and local government. The aim of the work placement was to give students experience in a workplace environment, but also included experiences such as contacting the placement host, organizing transport to and from the placement, and being in the workplace for seven to eight hours per day. This paper presents the areas of exploration for the study; a literature review relevant to the topic; the methodology used in the study; the results of the study; a discussion of the results; and a conclusion with recommendations.
Home testing for pediatric obstructive sleep apnea syndrome secondary to adenotonsillar hypertrophy

The objective of this study was to determine the accuracy and practicality of home testing for pediatric obstructive sleep apnea syndrome (OSAS) secondary to adenotonsillar hypertrophy. Twenty‐one children aged 2‐12 years and referred for possible OSAS were studied twice, once at home and once in the sleep laboratory. The home test consisted of two parts: (1) a cardiorespiratory recording of saturation (SaO2), pulse rate, pulse waveform, electrocardiogram, and respiratory inductive plethysmography; and (2) an 8‐hour videotape recording of the sleeping child. In the laboratory, standard nocturnal polysomnography including electroencephalography was performed. Experiences with another 62 children who underwent home testing alone were also reviewed and are reported. At home, saturation, respiratory, and video data were obtained 96.4 ± 13.3% (mean ± SD) 99.4 ± 1.6%, and 90.0 ± 7.8% of the time, respectively. The sleep efficiency was greater at home than in the laboratory, 91.1 ± 3.9% vs. 86.1 ± 7.2%, with a mean difference of 5.0% (P < 0.01). The median environmentally induced movement/arousal index was lower in the home than in the laboratory, 0.0 (inter‐quartile range, 0.0‐0.3) vs. 2.4/hr (inter‐quartile range 1.2–4.2), with a median difference of 2.4/hr (P < 0.001). Study duration, apne/dhypopnea index, desaturation index, respiratory and spontaneous movement/arousal indices, and oxygen saturation during sleep were similar for home and laboratory studies. Although neither sleep state nor PCO2, (transcutaneous or end‐tidal) was measured in the home, this information would have modified patient management in, at most, one case. In the second group of 62 children, exclusively studied at home, all studies were successfully recorded despite a wide range of sleep efficiencies, apne/dhypopnea indices, and desaturation indices. We conclude that home testing, using a simplified cardiorespiratory montage plus video recording, is accurate and of practical use in the routine evaluation of OSAS in patients with adenotonsillar hypertrophy. Pediatr Pulmonol. 1995; 20:241–252. © 1995 Wiley‐Liss, Inc.
Chemical composition of essential oil of Zygophyllum fabago L. from North-West Iran.

Essential oils from the aerial parts of Zygophyllum fabago L. (Zygophyllaceae) were obtained by hydrodistillation and were analysed by GC-MS system. Mass fraction of oils was 0.6% on a dry weight basis. Twenty-seven compounds representing 82.6% of the isolate were identified, among which sesquiterpenes dominated. The most abundant components were (Z)lanceol acetate (11.9%), geranyl valerate (8.1%), (6E,10Z)-pseudo phytol (7.4%).
Private Pareto Optimal Exchange

We consider the problem of implementing an individually rational, asymptotically Pareto optimal allocation in a barter-exchange economy where agents are endowed with goods and preferences over the goods of others, but may not use money as a medium of exchange. Because one of the most important instantiations of such economies is kidney exchange—where the “input” to the problem consists of sensitive patient medical records—we ask to what extent such exchanges can be carried out while providing formal privacy guarantees to the participants. We show that individually rational allocations cannot achieve any non-trivial approximation to Pareto optimality if carried out under the constraint of differential privacy—or even the relaxation of joint-differential privacy, under which it is known that asymptotically optimal allocations can be computed in two sided markets (Hsu et al. STOC 2014). We therefore consider a further relaxation that we call marginal-differential privacy—which promises, informally, that the privacy of every agent i is protected from every other agent j ≠ i so long as j does not collude or share allocation information with other agents. We show that under marginal differential privacy, it is possible to compute an individually rational and asymptotically Pareto optimal allocation in such exchange economies.
No relationship between baseline salivary alpha-amylase and State-Trait Anxiety Inventory Score in drug-naïve patients with short-illness-duration first episode major depressive disorder: An exploratory study

Background Salivary α-amylase (sAA) activity alternations are observed in major depressive disorder (MDD) being associated with depression severity and its specific psychopathological dimensions with anxiety being attributed to distress. No data is available on sAA in MDD according to Hamilton Rating Scale for Depression (HAMD-17) and State-Trait Anxiety Inventory (STAI). The exploratory study examines whether and to what extent baseline sAA level is interrelated to the psychopathological features including severity of symptoms and specific psychopathological dimensions. Material and Methods The basal, non-stimulated sAA activity was studied in 20 non-late-life adult, treatment-naïve MDD patients with short-illness-duration and in 20 age- and sex-matched healthy controls along with psychometric assessments with Hamilton Rating Scale for Depression (HAMD-17) and Spielberger State-Trait Anxiety Inventory (STAI). Results Significantly lower (p=0.011) sAA activity was observed in MDD as compared to controls. No significant correlations were observed between sAA activity and the total HAMD-17 score as well as with regard to the specific core depression, insomnia, anxiety and somatic HAM-D psychopathological dimensions. No significant correlations were also found between sAA and STAIX-1 and STAIX-2 scores. Conclusions Low baseline sAA levels in MDD with no correlations between sAA and psychopathological features including severity of symptoms and specific psychopathological dimensions was found. Key words:Salivary alpha-amylase, major depressive disorder, Spielberger State-Trait Anxiety Inventory, Hamilton Rating Scale for Depression.
Detailed chemical composition of the open cluster IC 4651: The iron peak, α elements, and Li

We present a detailed chemical analysis of 22 stars along the colour-magnitude sequence of the intermediate-age (1.7 Gyr) open cluster IC 4651, based on high-resolution, high S/N ratio spectra from UVES/VLT. IC 4651 thus becomes one of the few open clusters for which a detailed composition analysis exists for stars spanning 3.5 mag, from solar-type main- sequence stars to giants above the RGB clump. In a strict comparison with the Sun, we find for the cluster a well-defined Fe abundance of (Fe/H) = 0.10 ± 0.03 (internal errors), with a reddening E(b − y) = 0.091. We also derive abundances for the α elements Mg, Si, Ti, and Ca and find a moderate enhancement of the three former elements, in excellent agreement with the results for field stars of similar Fe abundance. Among the Fe group elements, Cr and Ni are slightly overabundant ((X/Fe) ∼ 0.05). As also observed in M 67, the Na abundance among the giants is more than 0.2 dex higher than in the dwarfs. We interpret this effect as real, and due to dredge-up of 23 Na in the giants. Four turnoff stars, all fairly rapid rotators (v sini ≥ 25 km s −1 ), appear to have higher (Fe/H) than the other stars; our tests show that, while a spurious enhancement of 0.1 dex can be produced by the effect of high rotation on our spectral analysis, this cannot explain the whole difference. These stars appear overabundant because we tend to overestimate their effective temperatures by forcing excitation equilibrium. Li abundances have been computed for all the stars and show a well-defined pattern: the Solar-type stars have an almost constant Li abundance, just below that of the Hyades, and the Li-dip is pronounced and well determined. Turnoff stars just above the dip have a "cosmic" Li abundance, but within a very small range of magnitudes (0.25 mag) higher on the turnoff ,t he Li level drops by more than a factor 10. This cannot be due just to dilution; rather some extra mixing is required. Among the giants, two probable clump stars show detectable Li, while all the other (likely) RGB stars do not - as is also observed in the similar cluster NGC 3680. None of these patterns can be explained by classical stellar evolution models. Again, some extra mixing is required. We show that rotating stellar models including the most recent developments for meridional circulation and turbulence by shear instabilities explain very well the behaviour of the lithium abundance along the colour-magnitude diagram of IC 4651, including subgiant and giant phases. The possibility remains open that the giants exhibiting the highest lithium abundances are actual RGB bump stars which have just been through the so-called "lithium flash".
Factors Associated With Age of Onset of Herpes Zoster Ophthalmicus

Purpose: The aim of this study was to evaluate factors associated with the age of onset of herpes zoster ophthalmicus (HZO) in the era of varicella vaccination. Methods: A retrospective series of 400 subjects with a diagnosis of HZO, and an analysis of public health databases. Variables studied included the age at onset, period of disease onset (1996–2004 and 2005–2012), sex, smoking habits, diabetes status, autoimmunity, and immunosuppressed status. Community data were gathered from the Oklahoma Outpatient Surgery Discharge Public Use Data File and the United States Census' American Community Survey data set. Results: The mean onset age was significantly lower for 2005 to 2012 as compared with 1996 to 2004 among females (mean decrease, 9.3 years; 95% confidence interval, 4.6–13.9 years; P < 0.0001), but the mean onset age was similar between the 2 periods among males (P = 0.640). Whereas 32.3% of the patients with zoster were <60 years old in 1996 to 2004, compared with 44.8% in the 2005 to 2012 period (&khgr;2 test: P = 0.017). In the multivariate model, smokers were found to have disease onset 11.5 (95% confidence interval, 6.9–16.1) years younger than nonsmokers. Conclusions: The proportion of younger patients with HZO increased, whereas the institutional and community data sets demonstrate a downward shift of the average age of onset of HZO among females. This may be an effect of widespread childhood varicella vaccination. Immunosuppression and smoking were also associated with a younger age of onset of HZO. This has implications for clinical care of patients at risk for developing HZO, as well as public health and vaccination policies.
Regulation of prostaglandin EP1 and EP4 receptor signaling by carrier-mediated ligand reuptake

After synthesis and release from cells, prostaglandin E2 (PGE2) undergoes reuptake by the prostaglandin transporter (PGT), followed by cytoplasmic oxidation. Although genetic inactivation of PGT in mice and humans results in distinctive phenotypes, and although experiments in localized environments show that manipulating PGT alters downstream cellular events, a direct mechanistic link between PGT activity and PGE2 (EP) receptor activation has not been made. Toward this end, we created two reconstituted systems to examine the effect of PGT expression on PGE2 signaling via two of its receptors (EP1 and EP4). In human embryonic kidney cells engineered to express the EP1 receptor, exogenous PGE2 induced a dose‐dependent increase in cytoplasmic Ca2+. When PGT was expressed at the plasma membrane, the PGE2 dose–response curve was right‐shifted, consistent with reduction in cell surface PGE2 availability; a potent PGT inhibitor acutely reversed this shift. When bradykinin was used to induce endogenous PGE2 release, PGT expression similarly induced a reduction in Ca2+ responses. In separate experiments using Madin–Darby Canine Kidney cells engineered to express the PGE2 receptor EP4, bradykinin again induced autocrine PGE2 signaling, as judged by an abrupt increase in intracellular cAMP. As in the EP1 experiments, expression of PGT at the plasma membrane caused a reduction in bradykinin‐induced cAMP accumulation. Pharmacological concentrations of exogenous PGE2 induced EP4 receptor desensitization, an effect that was mitigated by PGT. Thus, at an autocrine/paracrine level, plasma membrane PGT regulates PGE2 signaling by decreasing ligand availability at cell surface receptors.
Oxygen taxis and proton motive force in Azospirillum brasilense

The microaerophilic nitrogen-fixing bacterium Azospirillum brasilense formed a sharply defined band in a spatial gradient of oxygen. As a result of aerotaxis, the bacteria were attracted to a specific low concentration of oxygen (3 to 5 microM). Bacteria swimming away from the aerotactic band were repelled by the higher or lower concentration of oxygen that they encountered and returned to the band. This behavior was confirmed by using temporal gradients of oxygen. The cellular energy level in A. brasilense, monitored by measuring the proton motive force, was maximal at 3 to 5 microM oxygen. The proton motive force was lower at oxygen concentrations that were higher or lower than the preferred oxygen concentration. Bacteria swimming toward the aerotactic band would experience an increase in the proton motive force, and bacteria swimming away from the band would experience a decrease in the proton motive force. It is proposed that the change in the proton motive force is the signal that regulates positive and negative aerotaxis. The preferred oxygen concentration for aerotaxis was similar to the preferred oxygen concentration for nitrogen fixation. Aerotaxis is an important adaptive behavioral response that can guide these free-living diazotrophs to the optimal niche for nitrogen fixation in the rhizosphere.