Miracle-dz/UniFAR-FTUs huggingface dataset:
p50cdc37 Acting in Concert with Hsp90 Is Required for Raf-1 Function

ABSTRACT Genetic screens in Drosophila have identified p50 cdc37 to be an essential component of the sevenless receptor/mitogen-activated kinase protein (MAPK) signaling pathway, but neither the function nor the target of p50 cdc37 in this pathway has been defined. In this study, we examined the role of p50 cdc37 and its Hsp90 chaperone partner in Raf/Mek/MAPK signaling biochemically. We found that coexpression of wild-type p50 cdc37 with Raf-1 resulted in robust and dose-dependent activation of Raf-1 in Sf9 cells. In addition, p50 cdc37 greatly potentiated v-Src-mediated Raf-1 activation. Moreover, we found that p50 cdc37 is the primary determinant of Hsp90 recruitment to Raf-1. Overexpression of a p50 cdc37 mutant which is unable to recruit Hsp90 into the Raf-1 complex inhibited Raf-1 and MAPK activation by growth factors. Similarly, pretreatment with geldanamycin (GA), an Hsp90-specific inhibitor, prevented both the association of Raf-1 with the p50 cdc37 -Hsp90 heterodimer and Raf-1 kinase activation by serum. Activation of Raf-1 via baculovirus coexpression with oncogenic Src or Ras in Sf9 cells was also strongly inhibited by dominant negative p50 cdc37 or by GA. Thus, formation of a ternary Raf-1–p50 cdc37 –Hsp90 complex is crucial for Raf-1 activity and MAPK pathway signaling. These results provide the first biochemical evidence for the requirement of the p50 cdc37 -Hsp90 complex in protein kinase regulation and for Raf-1 function in particular.
When i’m right you’re wrong: attitude correctness facilitates anger and approach motivation toward opposing individuals

ABSTRACT Attitude correctness and attitude clarity define the broader concept, attitude certainty. Repeating one’s attitude to oneself causes attitude clarity, while learning that the majority of others agree with you causes attitude correctness. The current research tests how attitude correctness influences emotions and behavioral intentions toward individuals with opposing attitudes. We predicted that compared to clarity, those high in attitude correctness would feel more anger toward an opposing individual and a stronger desire to confront, oppose, and argue with them. Results across two studies supported predictions; believing that you hold the same attitude as the majority sparks feelings of anger toward individuals with differing viewpoints. The current work contributes to our understanding of heated debates and ugly confrontations.
Insights into Variability of Actinorhodopsin Genes of the LG1 Cluster in Two Different Freshwater Habitats

Actinorhodopsins (ActRs) are recently discovered proteorhodopsins present in Actinobacteria, enabling them to adapt to a wider spectrum of environmental conditions. Frequently, a large fraction of freshwater bacterioplankton belongs to the acI lineage of Actinobacteria and codes the LG1 type of ActRs. In this paper we studied the genotype variability of the LG1 ActRs. We have constructed two clone libraries originating from two environmentally different habitats located in Central Europe; the large alkaline lake Mondsee (Austria) and the small humic reservoir Jiřická (the Czech Republic). The 75 yielded clones were phylogenetically analyzed together with all ActR sequences currently available in public databases. Altogether 156 sequences were analyzed and 13 clusters of ActRs were distinguished. Newly obtained clones are distributed over all three LG1 subgroups - LG1-A, B and C. Eighty percent of the sequences belonged to the acI lineage (LG1-A ActR gene bearers) further divided into LG1-A1 and LG1-A2 subgroups. Interestingly, the two habitats markedly differed in genotype composition with no identical sequence found in both samples of clones. Moreover, Jiřická reservoir contained three so far not reported clusters, one of them LG1-C related, presenting thus completely new, so far undescribed, genotypes of Actinobacteria in freshwaters.
Further analysis on the flexural behavior of concrete-filled round-ended steel tubes

A new form of composite column, concrete-filled round-ended steel tubes (CFRTs), has been proposed as piers or columns in bridges and high-rise building and has great potential to be used in civil engineering. Hence, the objective of this paper presents an experimental and numerical investigation on the flexural behavior of CFRTs through combined experimental results and ABAQUS standard solver. The failure mode was discussed in detail and the specimens all behaved in a very ductile manner. The effect of different parameters, including the steel ratio and aspect ratio, on the flexural behavior of CFRTs was further investigated. Furthermore, the feasibility and accuracy of the numerical method was verified by comparing the FE and experimental results. The moment vs. curvature curves of CFRTs during the loading process were analyzed in detail. The development of the stress and strain distributions in the core concrete and steel tube was investigated based on FE models. The composite action between the core concrete and steel tube was discussed and clarified. In addition, the load transfer mechanism of CFRT under bending was introduced comprehensively. Finally, the predicted ultimate moment according to corresponding designed formula is in good agreement with the experimental results.
Deep Overcomplete Tensor Rank-Decompositions

We introduce new dictionary learning methods for tensor-variate data. Our model need not be separable and we infer the tensor-rank of each dictionary atom. This is possible through the novel combination and extension of beta-process factor analysis (BPFA) and the multiplicative gamma process CANDECOMP/PARAFAC (MGP-CP). We also extend our tensor factor analysis (TFA) model to a deep convolutional setting. We test our approach on image processing and classification tasks achieving state of the art results for inpainting and Caltech 101. The experiments also show that atom-rank impacts overcompleteness and sparsity.
Breast cancer survivorship and South Asian women: understanding about the follow-up care plan and perspectives and preferences for information post treatment.

BACKGROUND AND OBJECTIVES As more treatment options become available and supportive care improves, a larger number of people will survive after treatment for breast cancer. In the present study, we explored the experiences and concerns of female South Asian (sa) breast cancer survivors (bcss) from various age groups after treatment to determine their understanding of follow-up care and to better understand their preferences for a survivorship care plan (scp). METHODS Patients were identified by name recognition from BC Cancer Agency records for sa patients who were 3-60 months post treatment, had no evidence of recurrence, and had been discharged from the cancer centre to follow-up. Three focus groups and eleven face-to-face semistructured interviews were audio-recorded, transcribed verbatim, cross-checked for accuracy, and analyzed using thematic and content analysis. Participants were asked about their survivorship experiences and their preferences for the content and format of a scp. RESULTS Fatigue, cognitive changes, fear of recurrence, and depression were the most universal effects after treatment. "Quiet acceptance" was the major theme unique to sa women, with a unique cross-influence between faith and acceptance. Emphasis on a generalized scp with individualized content echoed the wide variation in breast cancer impacts for sa women. Younger women preferred information on depression and peer support. CONCLUSIONS For sa bcss, many of the psychological and physical impacts of breast cancer diagnosis and treatment may be experienced in common with bcss of other ethnic backgrounds, but the present study also suggests the presence of unique cultural nuances such as spiritual and language-specific support resource needs. The results provide direction for designing key content and format of scps, and information about elements of care that can be customized to individual patient needs.
Pregnancy Loss and Maternal Methemoglobin Levels: An Indirect Explanation of the Association of Environmental Toxics and Their Adverse Effects on the Mother and the Fetus

The aim of this epidemiologic study was to point out a relationship between the exposure to products of coal combustion, and complications in pregnancy where one third of causes of stillbirth are still unknown. In the town of Labin (Croatia) a coal-powered thermoelectric power plant is the single major air polluter. We compared the records of miscarriages, premature births and stillbirths in two periods: the control and the exposure period. Data on reproductive loss was based on the records of pregnant women visiting for regular monthly pregnancy checkups. At the time of the epidemiological prospective study, 260 women (n = 138 in the clean period and n = 122 in the dirty period) were considered representative. The data were processed using Chi square and correlation tests. The frequencies of miscarriages and stillbirths were significantly lower in the control than in the exposure period (p < 0.05). Methemoglobinemia and stillbirths recorded over the “exposure” period are significantly higher than in the “control” period (p = 0.0205). The level of methemoglobin in the bloodstream is an worthy biomarker, predictor and precursor of environmental toxics’ adverse effects on the mother and fetus, and can indirectly explain the unrecognized level of fetal methemoglobin. Methemoglobin and heme, having prooxidant properties, also cause the early and late endothelial dysfunction of vital organs. Despite our retrospective epidemiological study findings, we emphasize that the rate of reproductive loss represents a hypothetical risk, which needs to be confirmed with further fetal clinical and anatomopatholgical researches about the effects of methemoglobin catabolism products on the fetal CNS.
A QSVD 1 approach to on-and off-line state-space identification

In an earlier paper (Moonen et al. 1989), an identification scheme has been presented, for computing state space models for multivariable linear time-invariant systems making use of (possibly noisy) input-output measurements only. This procedure is heavily based on the singular value decomposition (SVD), a numerical technique known to be very robust and accurate when dealing with noisy data. Making use of consistency results for the SVD, the identification procedure can be shown to provide consistent results if both the input and output data are corrupted by additive white (measurement) noise. In the present paper, this identification procedure will be reformulated making use of the quotient singular value decomposition (QSVD), where the input-output error covariance matrix can be taken into account explicitly, thus extending the applicability of the identification scheme to the case where the input and output data are corrupted by coloured noise. It turns out that in practice, due to the use of various pre-filtering techniques (anti-aliasing etc.), this latter case is mostly encountered. The extended identification scheme then explicitly compensates for the filter characteristics, as will be demonstrated. Consistency of the identification results follows from consistency results for the QSVD. The usefulness of this generalization will be demonstrated by a few instructive examples. Finally, adaptive versions for on-line model updating can be devised as well, making use of QSVD-updating techniques. The present development is heavily inspired by recent progress in total least squares solution techniques (Van Huffel 1989) for the identification of static linear relations. The presented identification scheme can therefore be viewed as the analogous counterpart for identifying dynamic linear relations.
Free-Positioning Wireless Power Transfer to Multiple Devices Using a Planar Transmitting Coil and Switchable Impedance Matching Networks

In this paper, an efficient free-positioning wireless power transfer (WPT) system for charging multiple devices is proposed. For the system, a planar transmitting (Tx) coil that consists of a spiral coil and concentric multiple parallel loops and switchable impedance matching networks (IMNs) at a transmitter are developed. Using the Tx coil, mutual inductance between the Tx coil and the receiving (Rx) spiral coils is made uniform in the effective charging area. The parallel loops are placed in the interior of the Tx coil, and the magnetic field is enhanced and controlled by adjusting the space in each parallel loop. For optimal design of the coil, an analysis method using an equivalent circuit is explained in detail. It is found that the current of one loop of a parallel loop is more than the input current and negative current flows on the other loop, while the total current of each parallel loop is constant. An array of parallel capacitors with a switch as the switchable IMN is used for the maximum power transfer efficiency corresponding to the number of devices. The reflection coefficients of the fabricated WPT system are under -10 dB at 6.78 MHz, regardless of the number of devices and positions. The WPT system has the maximum power transfer efficiencies of 93% for two devices and simultaneously transfers uniform power to up to four devices with high efficiency.
The Structure of Paintings: Formal Grammar and Design

Although substantial literature exists on the properties of formal grammars, much less has been written on the use of grammars for describing the languages which they are capable of explaining. Thus we see a well-developed theory concerning the expressive (generative) power of different kinds of formal grammars and powerful algorithmic methods (analytical) for the languages defined by these grammars. For natural spoken and written languages, grammars have been used for explaining their structure but for the two-dimensional generalization to designs, pictures, images, and fine arts, which has been known since 1964, almost no use has been made of grammars. The purpose of this paper is to call attention to the powerful dormant tools that can be used in the design arts. Some of the benefits of using these tools for describing existing (natural) design languages are discussed. How such uses may direct us from the more formal design arts into the fine arts is discussed by reporting progress on building a grammar for a class of contemporary paintings.
Human umbilical-cord-blood mononucleated cells enhance the survival of lethally irradiated mice: dosage and the window of time

The purpose of this study was to evaluate the window of time and dose of human umbilical-cord-blood (HUCB) mononucleated cells necessary for successful treatment of radiation injury in mice. Female A/J mice (27–30 weeks old) were exposed to an absorbed dose of 9–10 Gy of 137Cs γ-rays delivered acutely to the whole body. They were treated either with 1 × 108 or 2 × 108 HUCB mononucleated cells at 24–52 h after the irradiation. The antibiotic Levaquin was applied 4 h postirradiation. The increased dose of cord-blood cells resulted in enhanced survival. The enhancement of survival in animals that received 2 × 108 HUCB mononucleated cells relative to irradiated but untreated animals was highly significant (P < 0.01). Compared with earlier studies, the increased dose of HUCB mononucleated cells, coupled with early use of an antibiotic, extended the window of time for effective treatment of severe radiation injury from 4 to 24–52 h after exposure.
HISTOPATHOLOGICAL EFFECTS IN MICE OF HETEROLOGOUS ANTILYMPHOCYTE SERUM

The effects of heterologous rabbit anti-mouse lymphocyte antiserum on the morphology of lymphoid and other tissues was investigated in CBA mice. The lymphoid tissues exhibited characteristic changes specific for ALS treatment, which were an invariable accompaniment to its immunosuppressive effects. These consisted of peripheral lymphopenia occurring at some time during a course of ALS treatment and persistent depletion of small lymphocytes in lymph node paracortical areas and splenic follicular periarteriolar zones. The thymic histology was generally well preserved. It is suggested that the relevant lesions reflect a rapid depletion of the pool of recirculating lymphocytes, possibly by a primary cytotoxic effect exerted on cells peripheral to lymphoid tissue. Other histologic features attendant to the administration of ALS were accounted for as consequences of immunization of ALS recipients to rabbit serum constituents or by the deleterious effects of antibodies directed against tissues other than lymphoid cells.
Antioxidative and root attributes response of chickpea parents and crosses under drought stress

Chickpea parents with contrasting root characters and their direct and reciprocal crosses were evaluated under control and drought stress created by withholding irrigation using specially designed root boxes at 50 per cent flowering stage. The crosses involving Vijay and ICC 4958 having deep and prolific root system as a male parent exhibited higher accumulation of osmolytes (proline and glycine betaine) and with higher activities of antioxidative enzymes (SOD, APX, CAT and GPX) with less increase in lipid peroxidation rate and less decrease in nitrate reductase. Amongst the chickpea crosses, the cross of ICC 4958 x Vijay recorded higher increase in root length of 78.77 percent with less reduction in RLWC. The high estimates of broad sense heritability and genetic advance as percent mean was observed in F2 generations of direct and reciprocal crosses for long root length.
Study of Javanese Ethnic Bullying Victims from Psychosocial Perspective

Bullying is a long-lasting phenomenon and until now it is still a problem in the world. Bullying behavior does not only occur in children and adolescents but also occurs in adults such as bullying in the workplace. Some researchers in the world have been researching the bullying behaviour associated with the state and culture. Culture is also linked to the ethnic that created the culture. The Javanese ethnic as part of the Indonesian nation has different characteristics from other ethnics that can not be straightforward, also obedient (setyatuhu), not reject and not rebel, gentle language, always low self-esteem in the association. This characteristic will actually prevent the occurrence of bullying, but the facts mention a lot of cases of bullying and victims of bullying in the people of Javanese ethnic. The occurrence of this bullying case can be explained from a psychosocial perspective. Psychosocial bullying victims have weak self-control, preferring to use external attributes and give up easily. This situation causes the victim of bullying to experience loneliness, social anxiety and withdrawal from the social environment. Keywords-victims of bullying, Javanese ethnic and
MUSIC THERAPISTS’ EXPERIENCES WITH CLIENTS WITH AUTISM SPECTRUM DISORDER WHO USE AUGMENTATIVE AND ALTERNATIVE COMMUNICATION

OF THESIS MUSIC THERAPISTS’ EXPERIENCES WITH CLIENTS WITH AUTISM SPECTRUM DISORDER WHO USE AUGMENTATIVE AND ALTERNATIVE COMMUNICATION Music therapists frequently work with clients with Autism Spectrum Disorder (ASD) who use Augmentative and Alternative Communication (AAC). The purpose of this study was to gather information on music therapists’ current experiences with AAC training as well as music therapists’ perceptions of their own communication abilities when communicating with clients who have ASD using their preferred AAC system. The researcher invited 7,279 board-certified music therapists to participate in this study via email, of which 366 completed the survey. Participants reported most often providing services to children and adolescents with ASD, and frequently using electronic AAC and electronic apps with their clients with ASD. The majority (71.2%) of participants stated that they would like additional training in the use of AAC. Of the music therapists who had participated in previous AAC training, many had received training at work or by an SLP or other certified professional. Results of this study provide information about the current practices and perceptions of board-certified music therapists working with clients with ASD.
Inhalation of Fine Particulate Air Pollution and Ozone Causes Acute Arterial Vasoconstriction in Healthy Adults

Background—Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function. Methods and Results—Twenty-five healthy adults underwent a randomized, double-blind, crossover study comparing the vascular response to the 2-hour inhalation of ≈150 &mgr;g/m3 of concentrated ambient fine particles (CAP) plus ozone (120 ppb) versus the response to the inhalation of filtered air. High-resolution vascular ultrasonography was used to measure alterations in brachial artery diameter, endothelial-dependent flow-mediated dilatation (FMD) and endothelial-independent nitroglycerin-mediated dilatation (NMD). Exposure to CAP plus ozone caused a significant brachial artery vasoconstriction compared with filtered air inhalation (−0.09±0.15 mm versus +0.01±0.18 mm, P =0.03). There were no significant differences in FMD (+0.29±4.11% versus −0.03±6.63%, P =0.88), NMD (+3.87±5.43% versus +3.46±7.92%, P =0.83), or blood pressure responses between exposures. Conclusions—Short-term inhalation of fine particulate air pollution and ozone at concentrations that occur in the urban environment causes acute conduit artery vasoconstriction.
Better Summarization Evaluation with Word Embeddings for ROUGE

ROUGE is a widely adopted, automatic evaluation measure for text summarization. While it has been shown to correlate well with human judgements, it is biased towards surface lexical similarities. This makes it unsuitable for the evaluation of abstractive summarization, or summaries with substantial paraphrasing. We study the effectiveness of word embeddings to overcome this disadvantage of ROUGE. Specifically, instead of measuring lexical overlaps, word embeddings are used to compute the semantic similarity of the words used in summaries instead. Our experimental results show that our proposal is able to achieve better correlations with human judgements when measured with the Spearman and Kendall rank coefficients.
Optimized link adaptation for wireless packet communications based on discrete-rate modulation and coding schemes

Adaptive modulation and coding (AMC) is a powerful technique for improving the spectral efficiency or the error performance in wireless packet networks over fading channels. In this article, using a fixed number of modulation and coding modes we propose a variable power transmission scheme for transmission of packets over block-fading wireless channels. We obtain the general form of optimal power adaptation and optimum AMC mode switching levels that maximize spectral efficiency under prescribed packet error rate (PER) constraint while satisfying an average transmit power constraint. Numerical results reveal that in wireless packet systems with limited packet length, the proposed scheme provides substantial average spectral efficiency gain when compared to the non-adaptive case. The optimization framework presented in this article would be useful for cross-layer optimization of physical layer in packet networks.