Miracle-dz/UniFAR-FTUs huggingface dataset:
Histogenesis of the cochlear nucleus of the mouse

In Nissl‐stained preparations of the cochlear nucleus there are nine recognizable cell types. These cells are born during three periods of histogenesis prenatally. On gestation days 10.0, 10.5, and 11.0 the pyramidal, giant, and dark‐staining cells are born. The spherical, globular, multipolar, and horizontal cells are formed on gestation days 12.0, 12.5, and 13.0 and small cells follow on gestation day 14.5. The onset of granule cell formation is gestation day 14.5 and continues to birth on gestation day 19. At birth, and for at least the first 2 postnatal weeks, glial cells are born. There are no regional gradients in cell birth dates, cells from all birth dates being intermixed. Cell birth proceeds in an orderly sequence that is related only to cell size. Although there were no apparent spatiotemporal patterns, some clustering of labeled cells was evident. These observations do not support the hypothesis that Golgi Type I cells precede Golgi Type II cells in their order of birth since both large and small neurons project beyond the nucleus. There is, nonetheless, a sequential pattern in the onset of cell birth for the auditory system, with cochlear nucleus neurons preceding cochlear neurons.
Online Monitoring of Voltage Stability Margin Using an Artificial Neural Network

In this paper, an artificial neural network (ANN) based method is developed for quickly estimating the long-term voltage stability margin. The investigation presented in the paper showed that node voltage magnitudes and the phase angles are the best predictors of voltage stability margin. Further, the paper shows that the proposed ANN based method can successfully estimate the voltage stability margin not only under normal operation but also under N-1 contingency situations. If the voltage magnitudes and phase angles are obtained in real-time from phasor measurement units (PMUs) using the proposed method, the voltage stability margin can be estimated in real time and used for initiating stability control actions. Finally, a suboptimal approach to determine the best locations for PMUs is presented. Numerical examples of the proposed techniques are presented using the New England 39-bus test system and a practical power system which consists of 1844 buses, 746 load buses, and 302 generator buses.
Greater India Basin hypothesis and a two-stage Cenozoic collision between India and Asia

Cenozoic convergence between the Indian and Asian plates produced the archetypical continental collision zone comprising the Himalaya mountain belt and the Tibetan Plateau. How and where India–Asia convergence was accommodated after collision at or before 52 Ma remains a long-standing controversy. Since 52 Ma, the two plates have converged up to 3,600 ± 35 km, yet the upper crustal shortening documented from the geological record of Asia and the Himalaya is up to approximately 2,350-km less. Here we show that the discrepancy between the convergence and the shortening can be explained by subduction of highly extended continental and oceanic Indian lithosphere within the Himalaya between approximately 50 and 25 Ma. Paleomagnetic data show that this extended continental and oceanic “Greater India” promontory resulted from 2,675 ± 700 km of North–South extension between 120 and 70 Ma, accommodated between the Tibetan Himalaya and cratonic India. We suggest that the approximately 50 Ma “India”–Asia collision was a collision of a Tibetan-Himalayan microcontinent with Asia, followed by subduction of the largely oceanic Greater India Basin along a subduction zone at the location of the Greater Himalaya. The “hard” India–Asia collision with thicker and contiguous Indian continental lithosphere occurred around 25–20 Ma. This hard collision is coincident with far-field deformation in central Asia and rapid exhumation of Greater Himalaya crystalline rocks, and may be linked to intensification of the Asian monsoon system. This two-stage collision between India and Asia is also reflected in the deep mantle remnants of subduction imaged with seismic tomography.
Aquatics, Flyers, Creepers and Terrestrials — students' conceptions of animal classification

There have been several investigations into students' conceptions of animal classification. Previous research has generally failed to study the criteria of classification used by the students. This study shows that students prefer to classify creatures along the criteria of habitat and locomotion (method of movement). They continue using these criteria even after learning the categories of biological taxonomy. The results lead to the assumption of an implicit theory of natural kinship of animals. The educational consequences for biology instruction, especially with regard to biological taxonomy, biodiversity, and evolution, are discussed.
The efficacy of a self-paced VO2max test during motorized treadmill exercise.

PURPOSE To assess the utility of a self-paced maximal oxygen uptake (VO2max) test (SPV) in eliciting an accurate measure of VO2max in comparison with a traditional graded exercise test (GXT) during motorized treadmill exercise. DESIGN This was a cross-sectional experimental study whereby recreationally trained men (n = 13, 25.5 ± 4.6 y) completed 2 maximal exercise tests (SPV, GXT) separated by a 72-h recovery period. METHODS The GXT was continuous and incremental, with prescribed 1-km/h increases every 2 min until the attainment of VO2max. The SPV consisted of 5 × 2-min stages of incremental exercise, which were self-selected and adjusted according to 5 prescribed RPE levels (RPE 11, 13, 15, 17, and 20). RESULTS Although no significant differences in VO2max were observed between the SPV and GXT (63.9 ± 3.3 cf 60.9 ± 4.6 mL · kg-1 · min-1, respectively, P > .05), the apparent 4.7% mean difference may be practically important. The 95% limits-of-agreement analysis was 3.03 ± 11.49 mL · kg-1 · min-1. Therefore, in the worst-case scenario, the GXT may underestimate measured VO2max as ascertained by the SPV by up to 19%. Conversely, the SPV could underestimate the GXT by 14%. CONCLUSIONS The current study has shown that the SPV is an accurate measure of VO2max during exercise on a motorized treadmill and may provide a slightly higher VO2max value than that obtained from a traditional GXT. The higher VO2max during the SPV may be important when prescribing training or monitoring athlete progression.
Tau Overexpression Results in Its Secretion via Membrane Vesicles

Background: Tau protein, the main component of neurofibrillary tangles, could be found in the extracellular space upon neuronal death or, as it has recently been suggested, could be secreted from cells through membrane vesicles. Objective: The purpose of this communication is to confirm that upon neuronal death, tau protein can be found, indeed, in the extracellular space and to analyze if tau could be secreted outside the cell in an alternative way. Methods: We have tested not only the extracellular release of tau, but also the toxicity of this extracellular tau. To do these studies, we have used neuronal cell cultures and tau-overexpressing non-neuronal cells. Membrane vesicles were isolated from culture medium from tau-overexpressing non-neuronal cells. Results: Our results indicate that extracellular tau, arising after neuron death, could be a toxic agent for neighboring neurons. On the other hand, we have found that an overexpression of tau protein could result in its secretion through membrane vesicles. However, the presence of this secreted tau does not result in cell death. Conclusion: We conclude that extracellular tau could arise by two different ways, by cell death or by secretion through membrane vesicles.
Peer interaction and the process of change in children's moral reasoning.

In order to study the manner in which peer interaction influences children's moral development, children ages 5 to 9 were videotaped in triads during peer discussions of a distributive justice problem. Pretests and posttests established that the 78 children who participated in these discussions were more likely to advance in their moral reasoning than were either children who discussed a similar justice problem with an adult or children who were merely exposed to the preand posttests. Videotapes of the peer discussions were analyzed to de termine the social-interactional characteristics of those children who advanced during the peer encounter. One observational coding scheme was used to as sess subjects' discourse patterns, and another scheme was used to code sub jects' modes of responding to others' statements. Children who engaged in re jecting, conflictual modes of interaction tended not to advance. Lower level children who did advance tended to focus on solutions pertaining to them selves, and tended to accept or transform (through compromise or collabora tion) the solutions of their peers. Higher level subjects who changed did so through social-interactional processes that were more varied and diverse than those of lower level children. The implication of these findings for theories of social interaction and developmental change are noted.
Electroluminescence and Photocurrent Generation from Atomically Sharp WSe2/MoS2 Heterojunction p–n Diodes

The p–n diodes represent the most fundamental device building blocks for diverse optoelectronic functions, but are difficult to achieve in atomically thin transition metal dichalcogenides (TMDs) due to the challenges in selectively doping them into p- or n-type semiconductors. Here, we demonstrate that an atomically thin and sharp heterojunction p–n diode can be created by vertically stacking p-type monolayer tungsten diselenide (WSe2) and n-type few-layer molybdenum disulfide (MoS2). Electrical measurements of the vertically staked WSe2/MoS2 heterojunctions reveal excellent current rectification behavior with an ideality factor of 1.2. Photocurrent mapping shows rapid photoresponse over the entire overlapping region with a highest external quantum efficiency up to 12%. Electroluminescence studies show prominent band edge excitonic emission and strikingly enhanced hot-electron luminescence. A systematic investigation shows distinct layer-number dependent emission characteristics and reveals important insight about the origin of hot-electron luminescence and the nature of electron–orbital interaction in TMDs. We believe that these atomically thin heterojunction p–n diodes represent an interesting system for probing the fundamental electro-optical properties in TMDs and can open up a new pathway to novel optoelectronic devices such as atomically thin photodetectors, photovoltaics, as well as spin- and valley-polarized light emitting diodes, on-chip lasers.
Outcome in Heart Failure with Preserved Ejection Fraction: The Role of Myocardial Structure and Right Ventricular Performance

Background Heart failure with preserved ejection fraction (HFpEF) is recognized as a major cause of cardiovascular morbidity and mortality. Thus, a profound understanding of the pathophysiologic changes in HFpEF is needed to identify risk factors and potential treatment targets in this specific patient population. Therefore, we aimed to comprehensively assess the impact of left- and right-ventricular function and hemodynamics on long-term mortality and morbidity in order to improve risk prediction in patients with HFpEF. Methods and Results We prospectively included 142 consecutive patients with HFpEF into our observational, non-interventional registry. Echocardiography, cardiac magnetic resonance imaging and invasive hemodynamic assessments including myocardial biopsy were performed at baseline. We detected significant correlations between left ventricular extracellular matrix and left ventricular end-diastolic diameter (r = -0.64;p = 0.03) and stroke volume (r = -0.53;p = 0.04). Hospitalization for heart failure and/or cardiac death was observed over a median follow up of 10 months. The strongest risk factors were reduced right ventricular function (adj. HR 6.62;95%CI 3.12- 14.02;p<0.001), systolic pulmonary arterial pressure (adj. HR per 1-SD 1.55;95%CI 1.15- 2.09;p = 0.004) and the pulmonary artery wedge pressure (adj. HR per 1-SD 1.51;95%CI 1.09–2.08; p = 0.012). The area under the ROC curve for right ventricular function was 0.63, for systolic pulmonary arterial pressure 0.75, and for pulmonary artery wedge pressure 0.68. Conclusion The current study emphasizes the importance of right ventricular function and pulmonary pressures on outcome in patients with HFpEF providing pathophysiological insights into the hemodynamic changes in HFpEF.
Nondestructive assessment of current one-step self-etch dental adhesives using optical coherence tomography

Abstract. This study aimed to nondestructively evaluate sealing performance of eight one-step self-etch adhesives (1-SEAs) using optical coherence tomography (OCT). The two-step self-etch adhesive (2-SEA) served as the control. Round tapered class-I cavities (D=4 mm, H=2 mm) were prepared in bovine incisors, treated with each adhesive (n=5), and restored with a flowable resin composite. Cross-sections were obtained from each restoration using swept-source OCT with 1310-nm laser. The average percentage of the sealed interface (SI%) for each adhesive was calculated using image analysis software, considering increased signal intensity at the interface as gap. Samples were then sectioned and observed under confocal laser scanning microscope (CLSM). Significantly different SI% values were found among different adhesives (analysis of variance, Bonferroni, p<0.05). There was also a significant correlation in SI% between OCT and CLSM (p<0.0001, r=0.96). Additionally, microscopic analysis revealed that the gaps in 1-SEAs occurred not only at dentine–adhesive interfaces but also frequently at adhesive–composite interfaces. Some recent 1-SEAs could achieve reliable short-term sealing comparable to 2-SEA. OCT is a unique tool to nondestructively evaluate the sealing performance of the restoratives through the cavity, provided that cavity walls have a certain minimum inclination with respect to the beam.
Standardized Antimicrobial Disc Susceptibility Testing of Anaerobic Bacteria. I. Susceptibility of Bacteroides fragilis to Tetracycline

A modified Bauer-Kirby-Sherris-Turck method for disc susceptibility testing of anaerobic bacteria is presented. When tetracycline was used against 100 strains of Bacteroides fragilis as a model, reasonably reproducible results were obtained after overnight incubation in both the GasPak atmosphere and an atmosphere achieved by adding 10% CO2 to a mixture of 10% H2 and 90% N2. The minimal inhibitory concentration for the strains determined by the agar dilution technique correlated well with the results of disc tests performed in the GasPak atmosphere with 30-μg tetracycline discs. Among 63 strains isolated from 1970 to the present, only 24 (38.1%) were found to be susceptible to tetracycline.
Improving routing efficiency for network-on-chip through contention-aware input selection

The performance of network-on-chip (NoC) largely depends on the underlying routing techniques, which have two constituencies: output selection and input selection. Previous research on routing techniques for NoC has focused on the improvement of output selection. This paper investigates the impact of input selection, and presents a novel contention-aware input selection (CAIS) technique for NoC that improves the routing efficiency. When there are contentions of multiple input channels competing for the same output channel, CAIS decides which input channel obtains the access depending on the contention level of the upstream switches, which in turn removes possible network congestion. Simulation results with different synthetic and real-life traffic patterns show that, when combined with either deterministic or adaptive output selection, CAIS achieves significant better performance than the traditional first-come-first-served (FCFS) input selection, with low hardware overhead (<3%)
Farm and animal exposures and pediatric brain tumors: results from the United States West Coast Childhood Brain Tumor Study.

Nineteen counties from San Francisco and Los Angeles, California and Seattle, Washington were the United States sites for a large population-based case-control study of childhood brain tumors (CBTs), sponsored by the National Cancer Institute. CBT patients who were < 20 years of age and were diagnosed between 1984 and 1991 were reported to each region's cancer registry. The 801 control subjects were obtained by random digit dial and were frequency-matched to the 540 CBT patients in San Francisco and Seattle (one patient to two controls) and in Los Angeles (one patient to one control). Data collected by in-person interview with subjects' mothers were analyzed to investigate an association between risk for CBTs and life on a farm, exposure to farm animals (dairy cattle, beef cattle, pigs, sheep/goats, poultry, and horses), and some cat and non-farm horse exposures. Elevated risks for CBTs were observed in association with mothers' exposure to pigs [odds ratio (OR) = 3.8, 95% confidence interval (CI) = 1.2-12] and horses (OR = 2.2, 95% CI = 1.0-4.8) on a farm during the index pregnancy. Children diagnosed with primitive neuroectodermal tumors showed elevated risks for CBTs with personal and maternal prenatal exposure to pigs (child, OR = 4.0, 95% CI = 1.2-13; mother, OR = 11.9, 95% CI = 2.8-51) and poultry (child, OR = 3.0, 95% CI = 1.1-8.0; mother, OR = 4.0, 95% CI = 1.2-14). No other animal exposures of children or mothers were found to be consistently related to CBTs. Children diagnosed with primitive neuroectodermal tumors who were on a farm for > 1 year and were first on a farm when they were < 6 months of age also had increased risk for CBTs (OR = 3.9, 95% CI = 1.2-13). A somewhat increased risk for CBTs was found for children of mothers who ever had worked on livestock farms compared with mothers who never had worked on a farm (OR = 7.4, 95% CI = 0.86-64, based on five case mothers and one control mother who worked on livestock farms during the 5 years preceding the birth of the index child). The associations are consistent with those of two previous studies in Norway (P. Kristensen et al., Int. J. Cancer, 65: 39-50, 1996) and the United States and Canada (G. R. Bunin et al., Cancer Epidemiol. Biomark. Prev., 3: 197-204, 1994) that investigated the role of farm-related exposures in the etiology of CBTs.
Low-Shot Visual Recognition by Shrinking and Hallucinating Features

Low-shot visual learning–the ability to recognize novel object categories from very few examples–is a hallmark of human visual intelligence. Existing machine learning approaches fail to generalize in the same way. To make progress on this foundational problem, we present a low-shot learning benchmark on complex images that mimics challenges faced by recognition systems in the wild. We then propose (1) representation regularization techniques, and (2) techniques to hallucinate additional training examples for data-starved classes. Together, our methods improve the effectiveness of convolutional networks in low-shot learning, improving the one-shot accuracy on novel classes by 2.3× on the challenging ImageNet dataset.
Response of piglets weaned from sows fed diets supplemented with conjugated linoleic acid (CLA) to an Escherichia coli K88+ oral challenge.

Seventy-eight Cotswold piglets weaned from sows receiving 0% or 2% conjugated linoleic acid (CLA)-supplemented rations from day 85 of gestation through lactation were allocated to nursery diets (ND) according to their dam's lactation ration (LR) as follows (1) 0%-0% (0% CLA LR: 0% CLA ND, n = 17); (2) 0%-2% (0% CLA LR: 2% CLA ND, n = 17); (3) 2%-0% (2% CLA LR: 0% CLA ND, n = 23); and (4) 2%-2% (2% CLA LR: 2% CLA ND, n = 21). At 28 ± 2 days of age all piglets received an oral Escherichia coli K88+ (enterotoxigenic Escherichia coli, ETEC) challenge and were subsequently monitored for scour development and overall health until 36 ± 2 days of age, after which blood and tissue samples were collected. Piglet BW was not affected by dietary CLA supplementation to LR (P > 0.05). However, by day 36 piglets receiving 2% CLA-supplemented ND were significantly lighter (P < 0.05) than piglets receiving control diets. Average daily gain and feed efficiency were not affected by CLA supplementation. Average daily feed intake (ADFI) was greater for piglets weaned from 2% CLA-supplemented sows from day 17 to 28 (P < 0.05), otherwise ADFI was unaffected by dietary CLA supplementation (P > 0.05). The development of scours was less severe in piglets weaned from 2% CLA-supplemented sows at 8, 24, 48 and 56 h after ETEC challenge (P < 0.05). Intestinal coliform and lactic acid bacteria populations post challenge were not affected by CLA supplementation. However, cecal ammonia-N was numerically greatest in 0%-0% piglets compared to the other treatment groups, and the total volatile fatty acid production was numerically lower in 0%-0% and 0%-2% piglets compared to 2%-0% and 2%-2% piglets. In addition, piglets weaned from 2% CLA-supplemented sows had increased serum immunoglobulin A (P < 0.001) and G (P < 0.05) levels and reduced (P < 0.05) intestinal mucosal inflammation compared to piglets weaned from control sows. Although there were no obvious additional health effects observed when CLA was provided in ND, supplementing sow rations with 2% CLA from mid-gestation through weaning appears to have immune-stimulating carry-over effects post weaning. Thus, supplementing sow rations with CLA may be a practical strategy for enhancing passive immune transfer and improving the immune status and overall gut health of nursery piglets.
Intensive insulin therapy decreases urinary MCP‐1 and ICAM‐1 excretions in incipient diabetic nephropathy

Background Nowadays, intensive insulin treatment has been widely used in type 2 diabetics who have poor control of blood glucose, to reduce the risk of chronic complications of diabetes. Recently, some scholars have paid more attention to the pivotal role of inflammation involved in type 2 diabetes and its complications. Monocyte chemoattractant protein‐1 (MCP‐1) and intercellular adhesion molecule‐1 (ICAM‐1), which are two important inflammatory chemokines, have been documented to participate in the onset and development of type 2 diabetes and its complications, such as diabetic nephropathy (DN).
Passive Reconfigurable Triple-Wideband Antenna for LTE Tablet Computer

A passive reconfigurable triple-wideband tablet computer antenna for the LTE operation in the low band of 698 ~ 960 MHz, middle band of 1710 ~ 2690 MHz, and high band of 3400 ~ 3800 MHz is presented. The antenna mainly acts like an inverted-F antenna (IFA) at frequencies in the LTE low and middle bands and like a loop antenna at frequencies in the LTE high band. The reconfigurable IFA/loop antenna is achieved without active switch circuits and occupies a small volume of 10 ×35 ×3 mm3. The antenna is obtained by first configuring the radiating arm of an IFA to be folded and coupled to the device ground plane through a distributed capacitor. Then, the IFA's shorting and feeding strips are respectively loaded with an inductor and a capacitor. This leads to good excitation of a resonant mode generated in the LTE low band with the radiating arm length of the IFA only about 0.16 wavelength at 800 MHz. By further aided using a high-pass matching circuit integrated within the antenna, a wide low band is obtained for the antenna. The IFA's first two higher-order modes can also be excited in the middle band. Owing to the distributed capacitor between the IFA's radiating arm and the device ground plane, the two higher-order modes can lead to a wide middle band for the antenna. At frequencies in the LTE high band, the antenna mainly acts like a loop antenna operated at its one-wavelength loop mode, which contributes to a wide high band for the antenna. Triple-wideband operation covering the LTE operation is hence obtained. Details of the proposed antenna are described, and experimental results are presented. Working principle of the antenna acting like an IFA and a loop antenna at different frequencies is discussed.