Miracle-dz/UniFAR-FTUs huggingface dataset:
HIV neuropathy: Insights in the pathology of HIV peripheral nerve disease

Abstract HIV‐associated neuropathies (HIV‐N) have become the most frequent neurological disorder associated with HIV infection. The most common forms of HIV‐N are the distal sensory polyneuropathy (DSP) and antiretroviral toxic neuropathies (ATN), disorders characterized mostly by sensory symptoms that include spontaneous or evoked pain that follow a subacute or chronic course. The main pathological features that characterize DSP and ATN include “dying back” axonal degeneration of long axons in distal regions, loss of unmyelinated fibers, and variable degree of macrophage infiltration in peripheral nerves and dorsal root ganglia. Marked activation of macrophages as well as the effect of proinflammatory cytokines appear to be the main immunopathogenic factors in DSP. Interference with DNA synthesis and mitochondrial abnormalities produced by nucleoside antiretrovirals have been hypothesized as pathogenic factors involved in ATN. The use of skin biopsy has become a useful tool in the evaluation of HIV‐N. Reduction in fiber density, increased frequency of fiber varicosities and fiber fragmentation are prominent features of skin biopsies from patients with HIV‐N. Other forms of HIV‐N include acute or chronic inflammatory polyneuropathies, uncommon disorders that may ocur during seroconversion or early stages of HIV infection. Opportunisitic infections, mostly associated with cytomegalovirus or herpes zoster virus infection occur in late stages of AIDS and produce characteristic clinical features such as mononeuritis multiple or radiculopathies.
Third Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria.

OBJECTIVES To collect recent data on the susceptibility of anaerobes and to compare them with results from previous studies. METHODS Four hundred and forty-three anaerobic clinical isolates from various body sites were prospectively collected from October 2003 to February 2005 in nine Belgian hospitals. MICs were determined for nine anti-anaerobic and three recently developed antibiotics. RESULTS Most gram-negative bacilli except Fusobacterium spp. were resistant to penicillin. Piperacillin/tazobactam, metronidazole, chloramphenicol, meropenem and amoxicillin/clavulanic acid were very active against all groups, but only 86% of Bacteroides fragilis group strains were susceptible to the latter. Cefoxitin, cefotetan and clindamycin were less active. In particular, only 62%, 52% and 48% of B. fragilis group strains were susceptible, respectively. Clindamycin shows a continuing decrease in activity, as 83% were still susceptible in 1987 and 66% in 1993-94. Anti-anaerobic activity of the new antibiotics is interesting, with MIC50 and MIC90 of 1 and >32 mg/L for moxifloxacin, 2 and 4 mg/L for linezolid and 0.5 and 8 mg/L for tigecycline. CONCLUSIONS The susceptibility of anaerobic bacteria remains stable in Belgium, except for clindamycin, which shows a continuous decrease in activity. However, for each of the tested antibiotics, at least a few resistant organisms were detected. Consequently, for severe infections involving anaerobic bacteria, it could be advisable to perform microbiological testing instead of relying on known susceptibility profiles. Periodically monitoring background susceptibility remains necessary to guide empirical therapy.
Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression.

The effects of short- and long-term load-controlled compression on the levels of aggrecan mRNA have been determined. Results show that a compressive stress of 0.1 MPa on bovine articular cartilage explants for 1, 4, 12, and 24 h produces a transient up-regulation of aggrecan mRNA synthesis. At 1 h, aggrecan mRNA levels in loaded explants were increased 3.2-fold compared to control explants. At longer times (>/=4 h), the levels of aggrecan mRNA returned to baseline values or stayed slightly higher. There is a dose dependence in the response of the explant to increasing levels of compressive stress (0-0.5 MPa) for 1 h. Aggrecan mRNA levels increased 2- to 3-fold at 0-0.25 MPa. At 0.5 MPa, the level of aggrecan mRNA was lower than those at 0.1 and 0.25 MPa. This dose-dependent effect suggests a reversal of the stimulatory effects of compression on aggrecan gene expression at higher loads. After 24 h of compression, the levels of aggrecan mRNA in explants subjected to any of the stress levels were not significantly different from those in control explants. The stimulatory effect of 0.1 MPa compressive stress on aggrecan mRNA levels was blocked by Rp-cAMP and U-73122, indicating the involvement of the classical signal transduction pathways in the mechanical modulation of aggrecan gene expression. The responses of link protein mRNA to compression paralleled those of aggrecan, while there was no significant change in expression of the gene for the housekeeping protein elongation factor-1 alpha. The results indicate that articular cartilage chondrocytes can respond to short-term compressive loads by transiently up-regulating expression of the aggrecan gene. The fact that long-term compression did not significantly alter aggrecan mRNA levels suggests that previously observed inhibitory effects of prolonged static compression on proteoglycan synthesis in articular cartilage may be, for the most part, mediated through mechanisms other than suppression of aggrecan mRNA levels.
Development and social capital

Abstract This paper examines social capital and its relation with economic development. We focus on the role that interpersonal relationships play in social exchange, whether through the market or through the provision of public goods. By facilitating search and trust, social capital can increase the efficiency of social exchange where formal institutions are weak. But the benefits from social capital are likely to be unequally distributed. Given these features, documenting empirically the benefits of social capital is complicated by the presence of negative and positive externalities and by the existence of leadership and group effects. Lessons for development policy are drawn at the end.
Corporate social responsibility, business strategy, and the environment

We examine the concept of firms sacrificing profits in the social interest within the environmental realm, with particular focus on the case of the United States by addressing four key questions. May they do so within the scope of their fiduciary responsibilities to their shareholders? Can they do so on a sustainable basis, or will the forces of a competitive marketplace render such efforts and their impacts transient at best? Do firms, in fact, frequently or at least sometimes behave this way, reducing their earnings by voluntarily engaging in environmental stewardship? Should firms carry out such profit-sacrificing activities (i.e. is this an efficient use of social resources)? We address these questions through the lens of economics, including insights from legal and business scholarship. Copyright 2010, Oxford University Press.
Pathways Linking Perceived Athletic Competence and Parental Support at Age 9 Years to Girls' Physical Activity at Age 11 Years

Girls' perceived athletic competence and parental support of physical activity across the ages of 9 to 11 years were examined as predictors of girls' physical activity at age 11 years. Participants were 174 girls and their mothers and fathers who completed questionnaires when the girls were ages 9 and 11 years. Two alternative temporal pathways linking perceived competence, parental support, and physical activity were assessed using path analysis. Results provided evidence for the child elicitation pathway; higher perceived competence at the age of 9 years predicted higher parental support at age 11 years, which, in turn, predicted higher physical activity among girls. Findings highlight the importance of encouraging parents to make a special effort to support physical activity among girls who do not perceive themselves as being athletically competent.
An experimental study on the noise properties of x-ray CT sinogram data in Radon space

Computed tomography (CT) has been well established as a diagnostic tool through hardware optimization and sophisticated data calibration. For screening purposes, the associated x-ray exposure risk must be minimized. An effective way to minimize the risk is to deliver fewer x-rays to the subject or lower the mAs parameter in data acquisition. This will increase the data noise. This work aims to study the noise property of the calibrated or preprocessed sinogram data in Radon space as the mAs level decreases. An anthropomorphic torso phantom was scanned repeatedly by a commercial CT imager at five different mAs levels from 100 down to 17 (the lowest value provided by the scanner). The preprocessed sinogram datasets were extracted from the CT scanner to a laboratory computer for noise analysis. The repeated measurements at each mAs level were used to test the normality of the repeatedly measured samples for each data channel using the Shapiro–Wilk statistical test merit. We further studied the probability distribution of the repeated measures. Most importantly, we validated a theoretical relationship between the sample mean and variance at each channel. It is our intention that the statistical test and particularly the relationship between the first and second statistical moments will improve low-dose CT image reconstruction for screening applications.
Trends in Marital Dissolution by Women's Education in the United States

I use the Survey of Income and Program Participation (N = 16,452) to measure trends in marital dissolution rates for U.S. women by education level. In marriage cohorts from the mid-1970s to the 1990s, marital dissolution rates fell among women with a 4-year college degree or more, but remained high among women with less than a 4-year college degree. This diverging trend began in the mid-1970s and is not explained by recent increases in women's overall educational attainment, nor by recent increases in age at marriage timing and premarital childbearing. These results suggest a growing association between socioeconomic disadvantage and family instability.
An Economic Index of Relative Riskiness

In their seminal works, Arrow (1965) and Pratt (1964) defined two aspects of risk aversion: absolute risk aversion and relative risk aversion. Based on their definitions, we define two aspects of risk: absolute risk and relative risk. We consider situations in which, by making an investment, an agent exchanges a certain amount of wealth w by a random distributed level of wealth W. In such situations, we define absolute risk as the riskiness of a gamble that is distributed as W-w, and relative risk as the riskiness of a security that is distributed as W/w. We measure absolute risk by the Aumann and Serrano (2008) index of riskiness and relative risk by an equivalent index that we develop in this paper. The two concepts of risk do not necessarily agree on which one of two investments is riskier, and hence they capture two different aspects of risk.
Just Say No to Wall Street: Putting a Stop to the Earnings Game

CEOs are in a difficult bind with Wall Street. Managers up and down the hierarchy work hard at putting together plans and budgets for the next year and quite often when those plans are completed top management discovers that the results fall far below what Wall Street expects. CEOs and CFOs are therefore left in a difficult situation. They can stretch to try to meet Wall Street's expectations or prepare to be punished if they fail. All too often top managers react to the situation by encouraging or mandating middle and lower level managers to redo their forecasts, plans and budgets to get them in line with external expectations. In some cases, fearing the results of missing the Street's expectations, managers start the budgeting process with the consensus expectations and mandate that internal budgets and plans be set so as to meet them. Either way this sets the firm and its managers up for failure if external expectations are, in fact, impossible for the firm to meet. We illustrate, with the experience of Enron and Nortel, the dangers of conforming to market pressures for growth that are essentially impossible. We emphasize that an overvalued stock can be as damaging to the long-run health of a company as an undervalued stock, a proposition that few managers are familiar with. An overvalued stock sets in motion a variety of organizational behaviors that often end up damaging the firm. It does not have to be this way. Ending the expectations game requires that CEOs reclaim the initiative in terms of setting expectations and forecasts. To begin, CEOs must say no to the earnings guidance game and reverse recent practices in which analysts took the lead in driving industry forecasts, and companies complied. Managers must make their organizations more transparent to investors, so that stocks can trade at close to their intrinsic value. Doing so means CEOs and CFOs must inform the market when they believe the market expectations cannot be met and that the stock is, therefore, overvalued.
Food scares, advertising, and the demand for meat cuts in Great Britain

Retail demand systems for 19 different cuts of meat for beef, lamb, pork, bacon and poultry in Great Britain are estimated from monthly time series of consumer expenditure from 1989–2000 using a two stage budget allocation process and an LA/AIDS specification. The unconditional expenditure, own and cross price elasticities are derived for the individual meat cuts. The impact of adverse publicity from meat scares, especially BSE, and of positive publicity through consumer promotion and advertising are incorporated into the modelling. Meat scares produced a reallocation of consumer spending from red to white meats during the 1990s. The impact of species-based advertising was shown to have complex spillover effects both within and between meat species, and the response of consumer demand to advertising was considerably less than to adverse publicity.
Signalling with Dividends? The Signalling Effects of Dividend Change Announcements: New Evidence from Europe

The dividend policy is one of the most debated topics in the finance literature. One of the different lines of research on this issue is based on the information content of dividends, which has motivated a significant amount of theoretical and empirical research. According to the dividend signalling hypothesis, dividend change announcements trigger share returns because they convey information about management's assessment on firms' future prospects. We start by analysing the classical assumptions of dividend signalling hypothesis. The evidence gives no support for a positive relation between dividend change announcements and the market reaction for French firms, and only a weak support for the Portuguese and the UK firms. After accounting for non-linearity in the mean reversion process, the global results do not give support to the assumption that dividend change announcements are positively related with future earnings changes. Afterwards, we formulate two hypotheses in order to explore the window dressing phenomenon and the maturity hypothesis, finding some evidence, especially in the UK market, for both of the phenomenon.
The resource boom and socio-economic well-being in Australian resource towns: a temporal and spatial analysis

The economy of Western Australia has long been characterized by a heavy dependence on extractive industries. The past decade, however, has seen the mining industry expand very rapidly, with significant implications for the small towns that support the sector. In this article, we consider the socio-economic performance of these towns through an assessment of unemployment, welfare dependence and incomes. In contrast to many other studies of resource boomtowns that typically focus on a single locality or time period, in this study we focus explicitly on spatial and temporal variability. We examine the ways in which place-specific characteristics—the commodity produced, local economic diversity and basic demographic features of a town—interact and have contributed to change in socio-economic well-being of mining communities across Western Australia over a 10-year period.
Which Map? Which Government? Malapportionment and Gerrymandering, UK-Style

Commentators suggest that the UK is entering a period in which general election results are unlikely to produce a clear winner. In such a situation, how and where the constituency boundaries are drawn is crucial, as different configurations of seats in particular places could have a significant impact on an election outcome. Although those configurations are recommended to Parliament by non-partisan Boundary Commissions, research has shown that Labour has been significantly advantaged by their recent proposals because they incorporated the equivalents of two well-known American electoral abuses – malapportionment and gerrymandering. This article illustrates how and why they have operated and discusses how the Conservatives’ failed attempt to remove one of them (malapportionment) and influence the other (gerrymandering) might have impacted on its position prior to the 2015 general election.
Rapid and proven production of transplastomic tobacco plants by restoration of pigmentation and photosynthesis.

Tobacco chloroplast transformation is typically achieved using dominant, selectable antibiotic resistance genes such as aadA, nptII and aphA-6. An improvement would be the combination of such a marker with a visual screening system for the early and conclusive detection of plastid transformants. As such, we investigated the use of three photosynthesis-deficient plastid mutants, DeltapetA, Deltaycf3 and DeltarpoA, for the development of a phenotypic selection system. Mutant plants were used as an alternative to the wild-type as source tissue for transformation, re-introducing deleted plastid sequences and using the aphA-6 gene as a selection marker. The reconstitution of the deleted genes in transformed regenerants resulted in shoots with a visually distinct phenotype comparable to the wild-type. This transformation/selection system overcomes the common problems associated with plastid transformation, e.g. the recovery of spontaneous mutants or nuclear insertions. In addition to the benefits offered by phenotypic selection, phenotype reconstitution leads to restoration of photosynthesis, which we assume drives reconstituted plants rapidly towards homoplasmy. As such, repeated cycles of regeneration in the presence of an antibiotic selection agent are no longer required.
Tourism and hospitality marketing: fantasy, feeling and fun

Purpose – Experiential marketing is arguably marketing's most contemporary orientation, but as with many marketing innovations it has been largely overlooked by those involved in tourism and hospitality marketing and promotion. Whilst in many industries companies have moved away from traditional features and benefits approaches, to putting experiential marketing centre‐stage, marketing in the tourism and hospitality sectors does not appear to have explicitly engaged the theoretical issues involved. This raises the question what, if anything, does experiential marketing have to offer marketers in the disciplines of tourism and hospitality? In this paper, I will seek to introduce the experiential marketing debate and demonstrate how the questions raised by the concept are critical to an understanding of marketing theory and research within the tourism and hospitality sectors.Design/methodology/approach – Following the authors previous publications which sought to investigate alternative paradigms for studyi.
Regional Returns to Education, Child Labor, and Schooling in India

We offer evidence from India that higher regional returns to primary education not only increase the likelihood that boys and girls attend school but also decrease the likelihood that they work. These relationships hold only for the top three quintiles of the income distribution and mostly for children in the age group 10-14 years. The former result suggests that liquidity constraints may not allow poorer households to respond to the economic benefits of education. Policies that raise the economic benefits of education may increase human capital investments in households that do not rely on their children's incomes for survival. However, low schooling and high child labour will persist among credit constrained families unless these households are provided with the economic ability to respond to these benefits.
A system level power consumption estimation for MPSoC

This paper proposes an efficient Hybrid System Level (HSL) power estimation methodology for MPSoC. Within this methodology, the Functional Level Power Analysis (FLPA) is extended to set up generic power models for the different parts of the system. Then, a simulation framework is developed at the transactional level to evaluate accurately the activities used in the related power models. The combination of the above two parts lead to a hybrid power estimation that gives a better trade-off between accuracy and speed. The proposed methodology has several benefits: it considers the power consumption of the embedded system in its entirety and leads to accurate estimates without a costly and complex material. The proposed methodology is also scalable for exploring complex embedded architectures. The usefulness and effectiveness of our HSL methodology is validated through a typical mono-processor and multiprocessor embedded system designed around the Xilinx Virtex II Pro FPGA board.
Who Needs Leaders the Most? The Interactive Effect of Leadership and Core Self-Evaluations on Commitment to Change in the Public Sector

ABSTRACT The purpose of this article is to shed light on an understudied topic in public administration, namely, commitment to organizational change. Specifically, this study examines the extent to which the quality of the relationship between employees and their managers positively influences employees’ commitment to change. Further, it investigates whether this relationship varies as a function of a person's core self-evaluations, that is, the valence of a person's self-regard. Evidence from a multivariate regression analysis in a public sector organization at the local level in the UK revealed that individuals who have high-quality relationships with their managers are more likely to be accepting of change; this is especially true for individuals with lower levels of core self-evaluations. Implications for theory and practice are discussed.
Local safety policy: The approach of two Swedish cities to urgent safety problems

This article explores local safety policy (LSP) developed to resolve urgent safety problems in two Swedish municipalities. It shows that local safety actors conceive and construct safety problems in ways that make them manageable, and that LSP evolves as a web of interactions between safety actors in the public and private sectors. The actors use established safety solutions and routines while exploring new ways of managing the problems. The municipalities’ problem-solving structures differ mainly in that different actors and institutions are involved. The policy process and features of LSP correspond well to how policy is portrayed in other cross-sectoral policy domains. Local safety policy development cannot easily be separated from policy implementation, nor can safety policy be separated from safety work, for they evolve together. The implication of this study for governance is that policy workers at different levels and from different organisations create LSP. Although LSP is partly initiated and legitimised at the political–administrative level, it is not from this level that it evolves.