Miracle-dz/UniFAR-FTUs huggingface dataset:
Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma

Background: There is uncertainty as to the dose of inhaled corticosteroids (ICS) at which to start concomitant long acting β agonist (LABA) treatment in patients with asthma not adequately controlled by ICS alone. Methods: A meta-analysis was carried out of randomised, double blind clinical trials that compared the efficacy of adding salmeterol to moderate doses of ICS (fluticasone propionate 200 μg/day or equivalent) with increasing the ICS dose by at least twofold in symptomatic adult patients with asthma. The main outcome measures were the number of subjects withdrawn from the study due to asthma and the number of subjects with at least one moderate or severe exacerbation. Results: Twelve studies with a total of 4576 subjects met the inclusion criteria for the analyses. The number of subjects withdrawn due to asthma and with at least one moderate or severe exacerbation was higher in the high dose ICS group (odds ratios 1.58, 95% CI 1.12 to 2.24 and 1.35, 95% CI 1.10 to 1.66, respectively). For the secondary outcome variables (forced expiratory volume in 1 second, morning and evening peak expiratory flow, and daytime β agonist use) there was significantly greater benefit in the salmeterol group. Conclusions: This meta-analysis shows that the addition of salmeterol to moderate doses of ICS (fluticasone 200 μg/day or equivalent) in patients with asthma symptomatic at that dose results in significantly greater clinical benefit than increasing the dose of ICS by twofold or more.
The Child is Father of the Man: Implications for the Demographic Transition

face a second trade-off in allocating their time between increasing their own human capital and rearing children. The model displays different regimes. In a Malthusian regime with no education fertility increases with adult life expectancy. In the modern growth regime, life expectancy and fertility move in opposite directions. The dynamics display the key features of the demographic transition, including the hump in both population growth and fertility, and replicate the observed rise in educational attainment, adult life expectancy and economic growth. Consistent with the empirical evidence, a distinctive implication of our theory is that improvements in childhood development precede the increase in education.
Evaluation of marginal likelihoods via the density of states

Bayesian model comparison involves the evaluation of the marginal likelihood, the expectation of the likelihood under the prior distribution. Typically, this high-dimensional integral over all model parameters is approximated using Markov chain Monte Carlo methods. Thermodynamic integration is a popular method to estimate the marginal likelihood by using samples from annealed posteriors. Here we show that there exists a robust and flexible alternative. The new method estimates the density of states, which counts the number of states associated with a particular value of the likelihood. If the density of states is known, computation of the marginal likelihood reduces to a onedimensional integral. We outline a maximum likelihood procedure to estimate the density of states from annealed posterior samples. We apply our method to various likelihoods and show that it is superior to thermodynamic integration in that it is more flexible with regard to the annealing schedule and the family of bridging distributions. Finally, we discuss the relation of our method with Skilling’s nested sampling.
Cellular correlate of assembly formation in oscillating hippocampal networks in vitro

Neurons form transiently stable assemblies that may underlie cognitive functions, including memory formation. In most brain regions, coherent activity is organized by network oscillations that involve sparse firing within a well-defined minority of cells. Despite extensive work on the underlying cellular mechanisms, a fundamental question remains unsolved: how are participating neurons distinguished from the majority of nonparticipators? We used physiological and modeling techniques to analyze neuronal activity in mouse hippocampal slices during spontaneously occurring high-frequency network oscillations. Network-entrained action potentials were exclusively observed in a defined subset of pyramidal cells, yielding a strict distinction between participating and nonparticipating neurons. These spikes had unique properties, because they were generated in the axon without prior depolarization of the soma. GABAA receptors had a dual role in pyramidal cell recruitment. First, the sparse occurrence of entrained spikes was accomplished by intense perisomatic inhibition. Second, antidromic spike generation was facilitated by tonic effects of GABA in remote axonal compartments. Ectopic spike generation together with strong somatodendritic inhibition may provide a cellular mechanism for the definition of oscillating assemblies.
Time Delay of CGM Sensors

Background: Continuous glucose monitoring (CGM) is a powerful tool to support the optimization of glucose control of patients with diabetes. However, CGM systems measure glucose in interstitial fluid but not in blood. Rapid changes in one compartment are not accompanied by similar changes in the other, but follow with some delay. Such time delays hamper detection of, for example, hypoglycemic events. Our aim is to discuss the causes and extent of time delays and approaches to compensate for these. Methods: CGM data were obtained in a clinical study with 37 patients with a prototype glucose sensor. The study was divided into 5 phases over 2 years. In all, 8 patients participated in 2 phases separated by 8 months. A total number of 108 CGM data sets including raw signals were used for data analysis and were processed by statistical methods to obtain estimates of the time delay. Results: Overall mean (SD) time delay of the raw signals with respect to blood glucose was 9.5 (3.7) min, median was 9 min (interquartile range 4 min). Analysis of time delays observed in the same patients separated by 8 months suggests a patient dependent delay. No significant correlation was observed between delay and anamnestic or anthropometric data. The use of a prediction algorithm reduced the delay by 4 minutes on average. Conclusions: Prediction algorithms should be used to provide real-time CGM readings more consistent with simultaneous measurements by SMBG. Patient specificity may play an important role in improving prediction quality.
48-Week Efficacy and Safety of Dolutegravir Relative to Commonly Used Third Agents in Treatment-Naive HIV-1–Infected Patients: A Systematic Review and Network Meta-Analysis

Background A network meta-analysis can provide estimates of relative efficacy for treatments not directly studied in head-to-head randomized controlled trials. We estimated the relative efficacy and safety of dolutegravir (DTG) versus third agents currently recommended by guidelines, including ritonavir-boosted atazanavir (ATV/r), ritonavir-boosted darunavir (DRV/r), efavirenz (EFV), cobicistat-boosted elvitegravir (EVG/c), ritonavir-boosted lopinavir (LPV/r), raltegravir (RAL), and rilpivirine (RPV), in treatment-naive HIV-1–infected patients. Methods A systematic review of published literature was conducted to identify phase 3/4 randomized controlled clinical trials (up to August 2013) including at least one third agent of interest in combination with a backbone nucleoside reverse transcriptase inhibitor (NRTI) regimen. Bayesian fixed-effect network meta-analysis models adjusting for the type of nucleoside reverse transcriptase inhibitor backbone (tenofovir disoproxil fumarate/emtricitabine [TDF/FTC] or abacavir/lamivudine [ABC/3TC]) were used to evaluate week 48 efficacy (HIV-RNA suppression to <50 copies/mL and change in CD4+ cells/µL) and safety (lipid changes, adverse events, and discontinuations due to adverse events) of DTG relative to all other treatments. Sensitivity analyses assessing the impact of NRTI treatment adjustment and random-effects models were performed. Results Thirty-one studies including 17,000 patients were combined in the analysis. Adjusting for the effect of NRTI backbone, treatment with DTG resulted in significantly higher odds of virologic suppression (HIV RNA<50 copies/mL) and increase in CD4+ cells/µL versus ATV/r, DRV/r, EFV, LPV/r, and RPV. Dolutegravir had better or equivalent changes in total cholesterol, LDL, triglycerides, and lower odds of adverse events and discontinuation due to adverse events compared to all treatments. Random-effects and unadjusted models resulted in similar conclusions. Conclusion Three clinical trials of DTG have demonstrated comparable or superior efficacy and safety to DRV, RAL, and EFV in HIV-1–infected treatment-naive patients. This network meta-analysis suggests DTG is also favorable or comparable to other commonly used third agents (ATV/r, LPV/r, RPV, and EVG/c).
Workshop on Computational Linguistics and Writing: Writing Processes and Authoring Aids (cl&w 2010) Grammaticality Judgement in a Word Completion Task Exploring Individual Differences in Student Writing with a Narrative Composition Support Environment Workshop Program Exploring Individual Difference

ii Introduction Writing today, whether professional, academic, or private, relies heavily on computers. Most texts composed in the 21st century are probably written on computers or other electronic devices, such as mobile phones. People compose texts in word processors, text editors, content management systems, blogs, wikis, e-mail clients, and instant messaging applications. Each of these tools supports authors in different ways and to different degrees. Writing research has been concerned with word processing since the 1970s. Writing researchers today investigate specific characteristics of writing with computers and the effect of tools on writing processes. The current rise of new writing environments and genres (e.g., blogging) has prompted new studies in this area of research. During the last few decades, computational linguistics has mostly been concerned with static or finished texts. We believe there is now a growing need to explore how computational linguistics can support human text production and word processing. However, there are still very few projects where computational linguists and writing researchers work together here. The Workshop on Computational Linguistics and Writing (CL&W 2010) provides an overview of current developments in the area of computational linguistics for authoring aids, and an overview of recent advances in writing research. The papers included here present research that explores writing processes and text production, as well as actual systems that support writers. In both areas, research on all languages is relevant, including less-resourced languages. CL&W 2010 brings together researchers from both communities, to identify areas where computational linguistics and writing research can benefit from each other and to stimulate discussion and interdisciplinary cooperation between these two areas of research. In our call for papers we posed some questions: • How can writing be supported by methods, resources, and tools from computational linguistics? This includes NLP tools and techniques that can be used or have been used to support writing (e.g., grammar and style checking, document structuring, thematic segmentation, and editing and revision aids). • How can we gain a better understanding of writing processes, strategies, and needs? How can techniques from HCI research and psychology help us to gain new insights into the composition and writing processes, and to improve writing tools? • Which methods, resources, and tools from computational linguistics might support research in this area? • How do high-level writing processes and the mechanics of writing relate to each other? • How does the tool used influence composition (including …
Generalized interlinked cycle cover for index coding

A source coding problem over a noiseless broadcast channel where the source is preinformed about the contents of the cache of all receivers, is an index coding problem. Furthermore, if each message is requested by one receiver, then we call this an index coding problem with a unicast message setting. This problem can be represented by a directed graph. In this paper, we first define a structure (we call generalized interlinked cycle (GIC)) in directed graphs. A GIC consists of cycles which are interlinked in some manner (i.e., not disjoint), and it turns out that the GIC is a generalization of cliques and cycles. We then propose a simple scalar linear encoding scheme with linear time encoding complexity. This scheme exploits GICs in the digraph. We prove that our scheme is optimal for a class of digraphs with message packets of any length. Moreover, we show that our scheme can outperform existing techniques, e.g., partial clique cover, local chromatic number, composite-coding, and interlinked cycle cover.
How the pediatric autopsy yields valuable information in a vertically integrated health care system.

CONTEXT Although autopsy rates have declined significantly in recent decades, studies continue to validate the autopsy as an important source of clinically relevant information, a teaching tool, and a quality assurance measure. A recent review of autopsy series showed a decline in the number of serious errors likely to have affected clinical outcome detected at autopsy during the past 46 years, with a current major error rate of 8.4% to 24.4%. OBJECTIVE Our hypothesis was that the pediatric autopsy would uncover a significant number of major unexpected findings at the high end of the spectrum predicted by a recent review. This study assesses the unexpected findings at a pediatric hospital whose autopsy service handles both in-house (tertiary care) and referral (mostly perinatal) cases for a vertically integrated health care system. DESIGN Data were analyzed from an autopsy effectiveness report completed for all autopsies performed in 2000. The data from this series include concordance of premortem and postmortem diagnoses, with the autopsy considered the criterion standard. The autopsy effectiveness report also provided logistic information, such as problems with consents, medical records, specimen identification, and prosection. SETTING Pediatric autopsies were performed by members of the Pediatric Pathology Division in a freestanding children's hospital in the Intermountain West of the United States with a large rural catchment area. This hospital is part of a large health maintenance organization serving the surrounding urban and rural areas. PATIENTS A sample of all in-house and referral autopsies for the year 2000 was examined. MAIN OUTCOME MEASURE The percentage of cases with a major or minor diagnostic discrepancy or unexpected pathologic finding using the autopsy as the criterion standard. RESULTS The overall autopsy rate was 40% (39 hospital autopsies and 15 forensic autopsies per 135 total deaths) and was 32% excluding forensic cases. Twenty-two additional referral autopsies from outside institutions were performed. Of 61 autopsies, 12 (20%) revealed a major diagnostic discrepancy or unexpected pathologic finding, 17 (28%) had a minor unexpected finding or additional diagnosis, 41 (67%) clarified the differential diagnosis, 46 (75%) confirmed or verified a major diagnosis, and 21 (34%) provided information regarding treatment effects. Additionally, 3 (5%) had problems with identification, and 12 (20%) had problems with consent, all of which were resolved prior to initiation of the autopsy. CONCLUSIONS These data confirm the value of the pediatric autopsy in a children's hospital and a vertically integrated health care system. It is an important medical and quality assurance procedure for assessing the accuracy of diagnoses, clarifying differential diagnoses, yielding unexpected findings, and providing feedback regarding therapeutic outcomes.
Interaction between categorical knowledge and episodic memory across domains

Categorical knowledge and episodic memory have traditionally been viewed as separate lines of inquiry. Here, we present a perspective on the interrelatedness of categorical knowledge and reconstruction from memory. We address three underlying questions: what knowledge do people bring to the task of remembering? How do people integrate that knowledge with episodic memory? Is this the optimal way for the memory system to work? In the review of five studies spanning four category domains (discrete, continuous, temporal, and linguistic), we evaluate the relative contribution and the structure of influence of categorical knowledge on long-term episodic memory. These studies suggest a robustness of peoples’ knowledge of the statistical regularities of the environment, and provide converging evidence of the quality and influence of category knowledge on reconstructive memory. Lastly, we argue that combining categorical knowledge and episodic memory is an efficient strategy of the memory system.
Primary extradural meningiomas: a report on nine cases and review of the literature from the era of computerized tomography scanning.

OBJECT Primary meningiomas arising outside the intracranial compartment (primary extradural meningiomas [PEMs]) are rare tumors. To develop a better understanding of these tumors and to establish a comprehensive classification scheme for them, the authors analyzed a series of patients treated at the M. D. Anderson Cancer Center (MDACC) and reviewed all cases reported in the English-language literature since the inception of the use of computerized tomography (CT) scanning. METHODS Clinical records, results of radiographic studies, and histological slides were reviewed for all cases of PEM at MDACC. Demographic features, symptoms, tumor location, histological grade, and patient outcome were assessed in all cases. A comprehensive literature search identified 168 PEMs in 142 patients reported during the CT era. These reports were also analyzed for common features. Tumors for both data sets were classified as purely extracalvarial (Type I), purely calvarial (Type II), and calvarial with extracalvarial extension (Type III). Type II and Type III tumors were further categorized as convexity (C) or skull base (B) lesions. The incidence of PEMs at MDACC was 1.6%, which was consistent with the rate reported in the literature. In both data sets, the male/female ratio was nearly 1:1. The most common presenting symptom was a gradually expanding mass. The age of patients at diagnosis of PEM was bimodal, peaking during the second decade and during the fifth to seventh decades. In all MDACC cases and in 90% of those reported in the literature the PEMs were located in the head and neck. The majority of tumors originated in the skull (70%). In the MDACC series and in the literature review, the majority (67% and 89%, respectively) of tumors were histologically benign. Although fewer PEMs were malignant or atypical (33% at MDACC and 11% in the literature), their incidence was higher than that observed for primary intracranial meningiomas. Distant metastasis was not a common feature reported for patients with PEMs (6% in the literature). Outcome data were available in 96 of the cases culled from the CT-era literature. The combination of the MDACC data and the data obtained from the literature demonstrated that patients with benign Type IIB or Type IIIB lesions were more likely to experience recurrence than patients with benign Type IIC or Type IIIC tumors (26% compared with 0%, p < 0.05). The more aggressive atypical and malignant tumors were associated with a statistically significant higher death rate (29%) relative to benign tumors (4.8% death rate, p < 0.004). CONCLUSIONS Defining a tumor as a PEM is dependent on the tumor's relation to the dura mater and the extent and direction of its growth. Classification of PEMs as calvarial or extracalvarial and as convexity or skull base lesions correlates well with clinical outcome.
Expression of BAFF and BR3 in patients with systemic lupus erythematosus

The objective of this study was to examine the relationship between the expression of B cell activating factor (BAFF) and BAFF receptor in patients with disease activity of systemic lupus erythematosus (SLE). Real-time RT-PCR was used to examine BAFF mRNA expression in peripheral blood monocytes of active and stable SLE patients and healthy controls. The percentage of BAFF receptor 3 (BR3) on B lymphocytes was measured by flow cytometry. Soluble BAFF levels in serum were assayed by ELISA. Microalbumin levels were assayed by an automatic immune analysis machine. BAFF mRNA and soluble BAFF levels were highest in the active SLE group, followed by the stable SLE group, and controls (P<0.01). The percentage of BR3 on B lymphocytes was downregulated in the active SLE group compared with the stable SLE group and controls (P<0.01). BAFF mRNA levels and soluble BAFF levels were higher in patients who were positive for proteinuria than in those who were negative (P<0.01). The percentage of BR3 on B lymphocytes was lower in patients who were positive for proteinuria than in those who were negative (P<0.01). The BAFF/BR3 axis may be over-activated in SLE patients. BAFF and BR3 levels may be useful parameters for evaluating treatment.
Syncope Associated With Supraventricular Tachycardia: An Expression of Tachycardia Rate or Vasomotor Response?

BackgroundSyncope in patients with supraventricular tachycardia has been suggested to be an ominous finding, predictive of rapid rates during tachycardia. Methods and ResultsTo explore the mechanism of syncope during supraventricular tachycardia, tachycardia was induced in the supine position and after passive head-up tilting to 60° in 13 patients with atrioventricular (AV) node reentry, eight patients with AV reentry, and one patient with atrial tachycardia. Tilt testing was also performed in sinus rhythm for 30 minutes (the last 15 minutes with isoproterenol infusion). Mean±SEM age was 38±3 years, and 11 patients had a history of syncope (median number of syncopal episodes, three; range, one to 30). The cycle length of tachycardia when upright was shorter than when supine (297±9 compared with 357±10 msec, p<0.001), and mean blood pressure fell to a greater extent after the onset of tachycardia (fall in mean blood pressure, 53±6 compared with 24±3 mm Hg, p<0.001). Mean blood pressure correlated significantly with tachycardia cycle length when supine (r = 0.58, p = 0.005) but not when tilted upright (r = 0.18, p = 0.45). Syncope occurred in seven patients during upright tachycardia. These seven patients had a greater fall in mean blood pressure with upright tachycardia than the 15 patients without syncope (fall in mean blood pressure, 70±4 compared with 45±5 mm Hg, p = 0.01), but there was no difference in the tachycardia cycle length (311±10 compared with 290±11 msec, p = 0.29). Six of the seven patients with tachycardia-induced syncope also had syncope with tilt testing in sinus rhythm compared with four of the 15 patients without tachycardia-induced syncope (p = 0.02). ConclusionsThese data support the view that syncope during supraventricular tachycardia is related to vasomotor factors and does not predict a more rapid tachycardia rate.