Miracle-dz/UniFAR-FTUs huggingface dataset:
Mixed-Affinity Binding in Humans with 18-kDa Translocator Protein Ligands

11C-PBR28 PET can detect the 18-kDa translocator protein (TSPO) expressed within macrophages. However, quantitative evaluation of the signal in brain tissue from donors with multiple sclerosis (MS) shows that PBR28 binds the TSPO with high affinity (binding affinity [Ki], ∼4 nM), low affinity (Ki, ∼200 nM), or mixed affinity (2 sites with Ki, ∼4 nM and ∼300 nM). Our study tested whether similar binding behavior could be detected in brain tissue from donors with no history of neurologic disease, with TSPO-binding PET ligands other than 11C-PBR28, for TSPO present in peripheral blood, and with human brain PET data acquired in vivo with 11C-PBR28. Methods: The affinity of TSPO ligands was measured in the human brain postmortem from donors with a history of MS (n = 13), donors without any history of neurologic disease (n = 20), and in platelets from healthy volunteers (n = 13). Binding potential estimates from thirty-five 11C-PBR28 PET scans from an independent sample of healthy volunteers were analyzed using a gaussian mixture model. Results: Three binding affinity patterns were found in brains from subjects without neurologic disease in similar proportions to those reported previously from studies of MS brains. TSPO ligands showed substantial differences in affinity between subjects classified as high-affinity binders (HABs) and low-affinity binders (LABs). Differences in affinity between HABs and LABs are approximately 50-fold with PBR28, approximately 17-fold with PBR06, and approximately 4-fold with DAA1106, DPA713, and PBR111. Where differences in affinity between HABs and LABs were low (∼4-fold), distinct affinities were not resolvable in binding curves for mixed-affinity binders (MABs), which appeared to express 1 class of sites with an affinity approximately equal to the mean of those for HABs and LABs. Mixed-affinity binding was detected in platelets from an independent sample (HAB, 69%; MAB, 31%), although LABs were not detected. Analysis of 11C-PBR28 PET data was not inconsistent with the existence of distinct subpopulations of HABs, MABs, and LABs. Conclusion: With the exception of 11C-PK11195, all TSPO PET ligands in current clinical application recognize HABs, LABs, and MABs in brain tissue in vitro. Knowledge of subjects’ binding patterns will be required to accurately quantify TSPO expression in vivo using PET.
Evaluating overflow probability for voice over internet protocol buffer dimensioning

The provision of quality of service to different service types in broadband packet networks requires techniques for the evaluation of the probabilities of packet delays and loss. The authors analyse the multiplexing of independent and homogeneous Markovian ON–OFF traffic sources into a single buffer, extending earlier work. The resulting closed-form equation provides a virtually zero-complexity approach to the calculation of the buffer overflow probability via the burst-scale decay rate of the buffer state probabilities. Graphical results are provided, comparing our expression with the results from simulations and the ‘standard’ formula of Anick, Mitra and Sondhi. These show that our new formula provides excellent accuracy for medium to high loads, i.e. those load values at which queuing becomes important. This makes it ideal for quick calculations, with practical utility when dimensioning checks are required in many networking situations involving the accurate estimation of loss probabilities in e.g. buffer multiplexing VoIP traffic sources.
Pay Distribution in the Top Executive Team

We investigate the distribution of pay in the top executive team in public companies. In particular, we study the CEO's pay slice (CPS), defined as the fraction of the aggregate top-five total compensation paid to the CEO. The level of a firm's CPS might reflect the relative centrality of the CEO in the top executive team in terms of ability, contribution to the firm, or power.We find that CPS has been going up over the past decade. During this period, CEOs have increased their fraction of both equity-based compensation and non-equity compensation. The level of CPS is associated with various characteristics of the top team and the firm's governance arrangements. Among other things, CPS is high when the CEO has long tenure; when the CEO chairs the board; when few other executives are members of the board; and when the firm has more entrenching provisions.High CPS is associated with lower firm value as measured by Tobin's Q. Using a simultaneous equations approach yields findings consistent with the possibility that this negative correlation is at least partly due to high CPS, or the relative CEO centrality it might reflect, bringing about a lower Tobin's Q. Consistent with the negative correlation between high CPS and Q, high CPS is associated with a less favorable market reaction, and a higher likelihood of a negative market reaction, to acquisitions announced by the firm. We also find that high CPS is associated with lower variability of stock returns over time. Overall, our results indicate that the distribution of compensation in the top executive team is an aspect of pay arrangements and corporate governance that deserves researchers' attention.
Physiological Assessment of Water Stress in Potato Using Spectral Information

Water stress in potato (Solanum tuberosum L.) causes considerable losses in yield, and therefore, potato is often considered to be a drought sensitive crop. Identification of water deficit tolerant potato genotypes is an adaptation strategy to mitigate the climatic changes that are occurring in the Cundiboyacense region in Colombia. Previous studies have evaluated potato plants under water stress conditions using physiological analyses. However, these methodologies require considerable amounts of time and plant material to perform these measurements. This study evaluated and compared the physiological and spectral traits between two genotypes, Diacol Capiro and Perla Negra under two drought levels (10 and 15 days without irrigation from flowering). Reflectance information was used to calculate indexes which were associated with the physiological behavior in plants. The results showed that spectral information was correlated (ρ < 0.0001) with physiological variables such as foliar area (FA), total water content (H2Ot), relative growth rate of potato tubers (RGTtub), leaf area ratio (LAR), and foliar area index (AFI). In general, there was a higher concentration of chlorophyll under drought treatments. In addition, Perla Negra under water deficit treatments did not show significant differences in its physiological variables. Therefore, it could be considered a drought tolerant genotype because its physiological performance was not affected under water stress conditions. However, yield was affected in both genotypes after being subject to 15 days of drought. The results suggested that reflectance indexes are a useful and affordable approach for potato phenotyping to select parent and segregant populations in breeding programs.
DiMaC: a disguised missing data cleaning tool

In some applications such as filling in a customer information form on the web, some missing values may not be explicitly represented as such, but instead appear as potentially valid data values. Such missing values are known as disguised missing data, which may impair the quality of data analysis severely. The very limited previous studies on cleaning disguised missing data highly rely on domain background knowledge in specific applications and may not work well for the cases where the disguise values are inliers. Recently, we have studied the problem of cleaning disguised missing data systematically, and proposed an effective heuristic approach [2]. In this paper, we present a demonstration of DiMaC, a Disguised Missing Data Cleaning tool which can find the frequently used disguise values in data sets without any domain background knowledge. In this demo, we will show (1) the critical techniques of finding suspicious disguise values; (2) the architecture and user interface of DiMaC system; (3) an empirical case study on both real and synthetic data sets, which verifies the effectiveness and the efficiency of the techniques; and (4) some challenges arising from real applications and several direction for future work.
Antimicrobial Resistance Patterns and Plasmid Profiles of Streptococcus Suis Isolates

Streptococcus suis isolates recovered from diseased animals in Quebec and western Canada and from human cases in Europe were tested for their susceptibility to different antimicrobial agents and screened for their plasmid content. Most isolates from Quebec were clindamycin, erythromycin, and tetracycline resistant; animal isolates from western Canada were notably less resistant to clindamycin and erythromycin, whereas human isolates were considerably more susceptible to most antimicrobials tested.1 More than 60% of isolates had plasmids that ranged from 1.5 to 35 kilobases (kb). Of the 7 plasmid profiles found, 2 were particularly frequent in isolates from Quebec and western Canada, suggesting the presence of epidemic strains in the swine population. A particular plasmid band of about 5 kb was present in most Canadian isolates. When this band was used as a probe in colony and Southem blot hybridization, most isolates harboring the 5-kb plasmid hybridized, even though their plasmid profiles were different. Human isolates from Europe differed in their plasmid content from Canadian isolates of animal origin. Although a high degree of antimicrobial resistance was associated with the presence of plasmids in most isolates, it was not possible to establish a causative relationship.
Will This Paper Increase Your h-index?: Scientific Impact Prediction

Scientific impact plays a central role in the evaluation of the output of scholars, departments, and institutions. A widely used measure of scientific impact is citations, with a growing body of literature focused on predicting the number of citations obtained by any given publication. The effectiveness of such predictions, however, is fundamentally limited by the power-law distribution of citations, whereby publications with few citations are extremely common and publications with many citations are relatively rare. Given this limitation, in this work we instead address a related question asked by many academic researchers in the course of writing a paper, namely: "Will this paper increase my h-index? " Using a real academic dataset with over 1.7 million authors, 2 million papers, and 8 million citation relationships from the premier online academic service ArnetMiner, we formalize a novel scientific impact prediction problem to examine several factors that can drive a paper to increase the primary author's h-index. We find that the researcher's authority on the publication topic and the venue in which the paper is published are crucial factors to the increase of the primary author's h-index, while the topic popularity and the co-authors' h-indices are of surprisingly little relevance. By leveraging relevant factors, we find a greater than 87.5% potential predictability for whether a paper will contribute to an author's h-index within five years. As a further experiment, we generate a self-prediction for this paper, estimating that there is a 76% probability that it will contribute to the h-index of the co-author with the highest current h-index in five years. We conclude that our findings on the quantification of scientific impact can help researchers to expand their influence and more effectively leverage their position of "standing on the shoulders of giants. "
Infection After Spinal Fusion for Pediatric Spinal Deformity: Thirty Years of Experience at a Single Institution

Study Design. A retrospective, consecutive case study of 1571 pediatric patients who underwent spinal deformity surgery and had minimum 2-year follow-up. Objective. To identify (1) the rate of infection after pediatric spinal deformity surgery; (2) the number of surgeries required to treat a postoperative infection after a pediatric spinal deformity surgery; (3) the percentage of patients with a postoperative infection after pediatric spinal deformity surgery who require implant removal to quantify the effect of removal on the deformity; and (4) the microbiology of postoperative infections after pediatric spinal deformity surgery. Summary of Background Data. Several previous reports have discussed the rates of infection after spinal surgery for pediatric spinal deformity. No previous reports have quantified the rate and magnitude of deformity progression after infection in pediatric spinal deformity surgery. Methods. A retrospective review was performed of the medical records and radiographs of all children undergoing surgery for spinal deformity at the Shriners Hospital for Children in Chicago from January 1, 1975, to June 1, 2005. Results. The rate of infection varied based on underlying diagnosis: idiopathic scoliosis 0.5%, myelomeningocele 19.2%, myopathies 4.3%, and cerebral palsy 11.2%. On average, 2 surgeries were required to eradicate the infection. Approximately half of the patients required removal of the instrumentation to treat their infection. Forty-four percent of patients who developed an infection had significant progression of their deformity, with an average increase in deformity magnitude of 27°. Implant removal predisposed patients to progression of deformity. The 3 most common organisms in order were Staphylococcus aureus, S. epidermidis, and Pseudomonas aeruginosa. Conclusion. Infection after spinal deformity in idiopathic scoliosis is rare but is relatively common in neuromuscular conditions. Eradication of infection can be expected, but implant removal is often required. Should implants be totally removed, significant progression of the deformity is possible.
Performance Increase for Highly-Loaded RoF Access Networks

This letter presents a medium access control (MAC) mechanism that allows for the effective use of the bandwidth of highly loaded 60 GHz Radio-over-Fiber (RoF) networks. We extend a previous approach proposed in the literature which is shown to have problems in highly-loaded cases. We propose a protocol that makes use of a memory buffer at the Central Office (CO) at the providers side that allows for the reduction of the number of polling packets required to identify all the active wireless nodes that need to transmit data. This greatly increases the overall throughput of the network at a maximum percentage of 42% for the examined configurations. The high throughput provided by our proposal is achieved without the need to update current infrastructure and only needs a trivial amount of memory at the provider's side.
Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes

More than one-fifth of ovarian tumors have hereditary susceptibility and, in about 65–85% of these cases, the genetic abnormality is a germline mutation in BRCA genes. Nevertheless, several other suppressor genes and oncogenes have been associated with hereditary ovarian cancers, including the mismatch repair (MMR) genes in Lynch syndrome, the tumor suppressor gene, TP53, in the Li-Fraumeni syndrome, and several other genes involved in the double-strand breaks repair system, such as CHEK2, RAD51, BRIP1, and PALB2. The study of genetic discriminators and deregulated pathways involved in hereditary ovarian syndromes is relevant for the future development of molecular diagnostic strategies and targeted therapeutic approaches. The recent development and implementation of next-generation sequencing technologies have provided the opportunity to simultaneously analyze multiple cancer susceptibility genes, reduce the delay and costs, and optimize the molecular diagnosis of hereditary tumors. Particularly, the identification of mutations in ovarian cancer susceptibility genes in healthy women may result in a more personalized cancer risk management with tailored clinical and radiological surveillance, chemopreventive approaches, and/or prophylactic surgeries. On the other hand, for ovarian cancer patients, the identification of mutations may provide potential targets for biologic agents and guide treatment decision-making.
Changes in Phospholipid Content and Myocardial Calcium-Independent Phospholipase A2 Activity during Chronic Anthracycline Administration

Despite numerous investigations, the causes underlying anthracycline cardiomyopathy are yet to be established. We have recently reported that acute treatment with anthracyclines inhibits membrane-associated calcium-independent phospholipase A2 (iPLA2) activity both in vitro and in vivo. This study presents data that iPLA2 activity is also suppressed during chronic drug administration. Adult Sprague-Dawley rats were given weekly 1 mg/kg i.v. injections of doxorubicin for a total of 8 weeks. One week after the last injection, the animals were sacrificed, and heart tissue was assessed for phospholipid content and iPLA2 activity. Membrane-associated iPLA2 activity in the myocardium of doxorubicin-treated animals was 40% lower than that in control hearts. In addition, doxorubicin treatment resulted in significant alterations in the distribution of fatty acyl moieties esterified to the sn-2 position of choline glycerophospholipids. The ethanolamine species remained unaffected. Elevation in the amount of arachidonate and linoleate esterified to the sn-2 position of choline plasmalogens was consistent with the hypothesis that iPLA2 displays selectivity for plasmalogen phospholipids; therefore, enzyme inhibition may affect hydrolysis of these phospholipid subclasses. Notably, the changes in phospholipid content occurred at a low cumulative dose of 8 mg/kg at which appearance of structural lesions was minimal. Therefore, these alterations seem to be both specific and early signs of cardiomyocyte pathology. The results support our hypothesis that myocardial iPLA2 inhibition may be one of the steps that leads to the functional and structural changes associated with chronic anthracycline treatment.
Incidence of renal dysfunction over 6 months in patients with chronic heart failure due to left ventricular systolic dysfunction: contributing factors and relationship to prognosis.

AIMS To determine the prevalence and incidence of renal dysfunction (RD) in patients with chronic heart failure (CHF), to identify contributory factors and predictors of worsening renal function (WRF), and to explore the relationship between RD and mortality. METHODS AND RESULTS Prospective data on 1216 patients with CHF were analysed. The glomerular filtration rate (GFR) was used to determine renal function, and WRF was defined as an increase in serum creatinine of >26.5 micromol/L (>0.3 mg/dL). The prevalence of RD defined as a GFR of <60 mL/min was 57%. During 6 months, WRF occurred in 161 (13.0%) patients. Predictors of WRF were vascular disease, the use of thiazide diuretics, and a baseline urea >9 mmol/L. Two hundred and sixty-three (21.6%) patients died, and baseline RD and WRF both predicted a higher mortality (P<0.001), whereas an improvement in renal function over the first 6 months predicted a lower mortality (hazard ratio 0.8, 95% confidence interval 0.6-1.0). CONCLUSION In ambulatory patients with CHF, RD is common, commonly deteriorates over a relatively short period of time, is unlikely to recover substantially, and augurs a poor prognosis.
Thermodynamic evaluation of the impact of strongly swelling polymer hydrogels with ionic silver on the water retention capacity of sandy substrate

The impact of two types of strongly swelling polymer hydrogel (SSPH) on the water retention capacity of quartz sand in pure water and Ag+ solutions (10-100 mg/l) has been studied by using a centrifugation method in a wide range of thermodynamic water potential (Gibbs energy) from 0 to 3030 J/kg. The experimental data for the water retention curves (WRC) were estimated by the van Genuchten model. Both hydrogels – the Aquasorb preparation (Germany) with hydrophilic properties and high degree of swelling in pure water (700–1000 g H2O/g) and the new Russian amphiphilic SSPH with a peat filler (degree of swelling 500-700 g H2O/g) were very effective as water adsorbing soil conditioners in relatively small doses from 0.05 to 0.3% per mass of dry (105°C) soil substrate. The water retention capacity of sandy substrate increases under the influence of SSPH with 2-3 times up to the level of native loamy sands and loams. Adding Ag+ to the water solution results just for the highest concentration of SSPH (0.3%) and iconic silver (100 mg/l) in a significant decrease of the water retention in the soil-gel compositions.
Detection of hyperreactive T cells in multiple myeloma by multivalent cross-linking of the CD3/TCR complex.

Cellular immunity was investigated in 43 patients with multiple myeloma (MM) by assessing 3HTdR uptake induced by monocyte-dependent [CD3 monoclonal antibodies (MoAbs), phytohemagglutinin (PHA)] and monocyte-independent (CD2 MoAbs, ionomycin + phorbolester) stimulations. The former were evaluated in peripheral blood mononuclear cells (PBMNC) and purified T cells; the latter were evaluated in purified T-cell preparations only. MM showed significantly lower PBMNC responses to PHA (P less than .001), soluble OKT3 (CD3) (P = .01), and immobilized OKT3 MoAbs (P = .01). On purification of T cells, MM responses were still defective to soluble T11(2) + T11(3) (CD2) MoAbs (P = .004), phorbol myristate acetate (PMA) plus ionomycin (P less than .001), but significantly higher to plastic-immobilized OKT3 (P = .004). In some MM, 3HTdR uptake, interleukin-2 (IL-2) receptor (CD25) expression, and IL-2 production were as high on stimulation with plastic-immobilized OKT3 as that observed in normal subjects under optimal conditions (ie, plastic-immobilized OKT3 plus accessory signals). CD3 hyperreactivity correlated with the number of CD8+ HLA-DR+ cells in MM T-cell preparations. MM patients with more than 10% CD8+ HLA-DR+ cells had significantly higher responses to immobilized OKT3 (P less than .001), but lower responses to T11(2) plus T11(3) (P = .01), and PMA plus ionomycin (P = .03) than patients with less than 10% CD8+ HLA-DR+ cells. Phenotyping of CD45RA (naive) and CD45R0 (memory) expressions in resting MM T cells showed a lower ratio of CD45RA to CD45R0 in both CD4 (P less than .05) and CD8 (P less than .001) subpopulations. These data indicate that (a) some MM T cells require significantly fewer accessory signals (if any) to express the IL-2 receptor fully, secrete IL-2, and proliferate on multivalent cross-linking of the CD3/TCR complex; and (b) this peculiar state of activation is associated with high HLA-DR expression in CD8+ lymphocytes.
Integrin α3β1 inhibits directional migration and wound re-epithelialization in the skin

Re-epithelialization after skin wounding requires both migration and hyperproliferation of keratinocytes. Laminin-332 is deposited during migration over the provisional matrix. To investigate the function of the laminin-332 binding integrin α3β1 in wound re-epithelialization, we generated Itga3flox/flox; K14-Cre mice lacking the α3 subunit specifically in the basal layer of the epidermis. These mice are viable but display several skin defects, including local inflammation, hair loss, basement membrane duplication and microblistering at the dermal-epidermal junction, whereas hemidesmosome assembly and keratinocyte differentiation are not impaired. Wound healing is slightly faster in the absence of integrin α3β1, whereas proliferation, the distribution of other integrins and the deposition of basement membrane proteins in the wound bed are unaltered. In vitro, cell spreading is rescued by increased surface expression of α6β1 integrin in the absence of integrin α3. The α3-deficient keratinocytes migrate with an increased velocity and persistence, whereas proliferation, growth factor signaling, hemidesmosome assembly, and laminin-332 deposition appeared to be normal. We suggest that integrin α3β1 delays keratinocyte migration during wound re-epithelialization, by binding to the laminin-332 that is newly deposited on the wound bed.