Miracle-dz/UniFAR-FTUs huggingface dataset:
Charge rearrangement deduced from nearby electric field measurements of an intracloud flash with K‒changes

An intracloud flash near Langmuir Laboratory is analyzed to determine the net rearrangement of charge. The analysis employed data from a balloon borne electric field sensor, or Esonde, that was within a few hundred meters of the lightning channel, data from a similar Esonde on a mountain about 6.4 km from the balloon, and data from the New Mexico Institute of Mining and Technology Lightning Mapping Array (LMA). The recovery of the charge transport required the solution of Poisson's equation over the mountainous terrain surrounding Langmuir Laboratory and the solution of a vastly under‒determined system of equations. The charge movement is analyzed using a new smooth charge transport model that incorporates constraints in the least squares fitting process through the use of penalty terms to smooth the charge movement and prevent data overfitting. The electric field measurements were consistent with about 26% of the negative charge being transported to the end of the channel, 36% deposited along the channel in the positive region, 8% deposited near the start of the channel in the positive region, and 30% deposited in another positive region several kilometers beneath the main channel. The transport of negative charge to a lower positive region occurred during the K‒processes when some negative charge was also deposited along the main channel in the upper positive region. Hence, the charge transport process during the K‒processes amounted to a tripolar charge rearrangement where the charge from the negative region was transported to two distinct positive regions, the positive region along the main channel and a lower positive region beneath the main channel. High altitude, widely scattered LMA sources beyond the end of the main channel could indicate the existence of streamers which transported the end‒of‒channel charge into the surrounding volume. Although the LMA showed the development of two upper channels, the charge transport analysis showed that measurable charge transport only occurred on one of the channels. The channel that did not transport charge was missing the high altitude, widely scattered LMA sources seen at the end of the channel that carried charge.
Classification Criteria for Distinguishing Cortisol Responders From Nonresponders to Psychosocial Stress: Evaluation of Salivary Cortisol Pulse Detection in Panel Designs

Objective Hypothalamic-pituitary-adrenal axis reactivity to acute stimulation is frequently assessed by repeated sampling of salivary cortisol. Researchers often strive to distinguish between individuals who show (responders) and those do not show (nonresponders) cortisol responses. For this, fixed threshold classification criteria, such as a 2.5-nmol/l baseline-to-peak increase, are frequently used. However, the performance of such criteria has not been systematically evaluated. Methods Repeated salivary cortisol data from 504 participants exposed to either the Trier Social Stress Test (TSST; n = 309) or a placebo protocol (n = 195) were used for analyses. To obtain appropriate classifications of cortisol responders versus nonresponders, a physiologically plausible, autoregressive latent trajectory (ALT) mixture model was fitted to these data. Response classifications according to the ALT model and information on the experimental protocol (TSST versus placebo TSST) were then used to evaluate the performance of different proposed classifier proxies by receiver operating characteristics. Results Moment structure of cortisol time series was adequately accounted for by the proposed ALT model. The commonly used 2.5-nmol/l criterion was found to be overly conservative, resulting in a high rate of 16.5% false-negative classifications. Lowering this criterion to 1.5 nmol/l or using a percentage baseline-to-peak increase of 15.5% as a threshold yielded improved performance (39.3% and 26.7% less misclassifications, respectively). Conclusions Alternative classification proxies (1.5 nmol/l or 15.5% increase) are able to effectively distinguish between cortisol responders and nonresponders and should be used in future research, whenever statistical response class allocation is not feasible.
Supplementary materials for: Plug & Play Generative Networks: Conditional Iterative Generation of Images in Latent Space

Assume a distribution p(x) that we wish to produce samples from. For certain distributions with amenable structure it may be possible to write down directly an independent and identically distributed (IID) sampler, but in general this can be difficult. In such cases where IID samplers are not readily available, we may instead resort to Markov Chain Monte Carlo (MCMC) methods for sampling. Complete discussions of this topic fill books [25, 4]. Here we briefly review the background that led to the sampler we propose. In cases where evaluation of p(x) is possible, we can write down the Metropolis-Hastings (hereafter: MH) sampler for p(x) [35, 18]. It requires a choice of proposal distribution q(x′|x); for simplicity we consider (and later use) a simple Gaussian proposal distribution. Starting with an x0 from some initial distribution, the sampler takes steps according to a transition operator defined by the below routine, with N(0, σ) shorthand for a sample from that Gaussian proposal distribution:
Accurate, Low Cost and Instrumentation-Free Security Audit Logging for Windows

Audit logging is an important approach to cyber attack investigation. However, traditional audit logging either lacks accuracy or requires expensive and complex binary instrumentation. In this paper, we propose a Windows based audit logging technique that features accuracy and low cost. More importantly, it does not require instrumenting the applications, which is critical for commercial software with IP protection. The technique is build on Event Tracing for Windows (ETW). By analyzing ETW log and critical parts of application executables, a model can be constructed to parse ETW log to units representing independent sub-executions in a process. Causality inferred at the unit level renders much higher accuracy, allowing us to perform accurate attack investigation and highly effective log reduction.
A Clinicopathological and Dermoscopic Correlation of Seborrheic Keratosis

Background: Seborrheic keratosis (SK) is the most common benign epidermal tumor of the skin. Even though SK has been well characterized clinically, dermoscopically, and histopathologically, data regarding clinical dermoscopic and histopathological correlation of different types of SK are inadequate. Aim: We carried out this study to establish any correlation between the clinical, dermoscopic, and histopathological appearance of SK and its variants. Methods: This was a descriptive study. Patients with SK were evaluated with respect to age, sex, family history of similar lesions, site of lesions, and symptoms associated with the lesions. Dermoscopy was performed in all cases. Biopsies were taken from the lesions and assessed for histopathology. Results: The most common age group affected by SK was 31–50 years (42%). A female preponderance of 76% was seen. Majority of our patients had a positive family history (62%), though Sun exposure was not seen to be a major factor. The most common clinical variant was common SK (CSK) (46%). The most common dermoscopic findings seen in CSK were comedo-like (CL) openings, fissures and ridges (FR), and milia-like (ML) cysts. Dermatosis papulosa nigra and pedunculated SK had characteristic FR and CL openings on dermoscopy. Stucco keratoses showed network-like (NL) structures and sharp demarcation. CL opening on dermoscopy corresponded to papillomatosis and pigmentation, ML cysts corresponded to horn cysts, FR corresponded to papillomatosis, and NL structures corresponded to an increase in basal layer pigmentation. Conclusions: This study emphasizes the use of dermoscopy in improving the diagnostic accuracy of SK. The correlation between the various histological and dermoscopic features is described.
Hemodynamic responses to electrical stimulation of the aortic depressor nerve in awake rats.

Changes in mean arterial pressure (MAP), heart rate (HR), and vascular resistance (hindquarter and mesenteric territories) in response to electrical stimulation (ES) of the aortic depressor nerve (ADN) were evaluated in conscious freely moving rats. Platinum electrodes were implanted into the ADN of all rats studied, and some of these animals were also implanted with miniaturized Doppler probes around the superior mesenteric artery and inferior abdominal aorta (hindquarter). In both groups, the femoral artery and vein were catheterized one day before the experiments. In the first group of rats ( n = 7), the control ES of the ADN in the range from 0.5 to 3.0 V (50 Hz, 10 ms) produced bradycardia and hypotension in an intensity-dependent manner, and treatment with methylatropine (intravenously) blocked the bradycardia but produced no significant changes in the hypotensive response. In a second group ( n = 6), ES of the ADN was performed with the intensity fixed at 3 V and the frequency of the stimuli varying from 10 to 50 Hz. In this group, the hypotensive response was frequency dependent, whereas the bradycardic response was not. In a third group of rats ( n = 6), ES of the ADN (2.5 V) produced hypotension (-35 ± 4 mmHg), minor changes in the mesenteric (+5 ± 14%), and vasodilation in hindquarter (-32 ± 6%) vascular beds. The data show that 1) ES of the ADN produces a fall in pressure, bradycardia, vasodilation in the hindquarter, and no changes in the mesenteric vascular resistance, 2) methylatropine blocked the bradycardia and produced no effect on the hypotensive response to ES of the ADN, and 3) the baroreceptor afferent fibers involved in the hypotensive response to ES of ADN are sensitive to the variation of the frequency of the stimuli, whereas the fibers involved in the bradycardic response are not.
Design of High-Directivity Compact-Size Conical Horn Lens Antenna

The design of lightweight, compact-size, and high-directivity conical horn lens antenna that covers both 71-76 and 81-86 GHz bands is presented in this letter. The conventional conical moderate-gain horn antenna is integrated with a planar inhomogeneous dielectric flat transmit-array lens having diameter of 35 mm and thickness of 6.35 mm by covering its aperture. The transmit-array lens is designed based on the perforating dielectric technique that is based on the drilling of numerous holes of variable diameters through a dielectric host material. The unit cell size is about λ0/2, which allows for easier fabrication. The proposed lens consists of eight concentric zones of same width of 2.32 mm and sharing the same host dielectric material. A directivity of 26.4 dBi, 9 dBi improvement, sidelobe level (SLL) of -15.7 dB at 74 GHz and directivity of 27 dBi, 9.9 dBi improvement, and SLL of -18.4 dB at 86 GHz were achieved. The proposed horn antenna is 44.46% shorter than the conventional horn antenna producing the same directivity, where the horn antenna length reduction is a result of using the proposed transmit-array lens.
Clonality, virulence and antimicrobial resistance of enteroaggregative Escherichia coli from Mirzapur, Bangladesh

Purpose. This study investigates the virulence and antimicrobial resistance in association with common clonal complexes (CCs) of enteroaggregative Escherichia coli (EAEC) isolated from Bangladesh. The aim was to determine whether specific CCs were more likely to be associated with putative virulence genes and/or antimicrobial resistance. Methodology. The presence of 15 virulence genes (by PCR) and susceptibility to 18 antibiotics were determined for 151 EAEC isolated from cases and controls during an intestinal infectious disease study carried out between 2007‐2011 in the rural setting of Mirzapur, Bangladesh (Kotloff KL, Blackwelder WC, Nasrin D, Nataro JP, Farag TH et al. Clin Infect Dis 2012;55:S232‐S245). These data were then analysed in the context of previously determined serotypes and clonal complexes defined by multi‐locus sequence typing. Results. Overall there was no association between the presence of virulence or antimicrobial resistance genes in isolates of EAEC from cases versus controls. However, when stratified by clonal complex (CC) one CC associated with cases harboured more virulence factors (CC40) and one CC harboured more resistance genes (CC38) than the average. There was no direct link between the virulence gene content and antibiotic resistance. Strains within a single CC had variable virulence and resistance gene content indicating independent and multiple gene acquisitions over time. Conclusion. In Bangladesh, there are multiple clonal complexes of EAEC harbouring a variety of virulence and resistance genes. The emergence of two of the most successful clones appeared to be linked to either increased virulence (CC40) or antimicrobial resistance (CC38), but increased resistance and virulence were not found in the same clonal complexes.
Vaccination against oncogenic human papillomavirus infection in HIV-infected populations: review of current status and future perspectives.

UNLABELLED Background Men and women with HIV infection are at increased risk of developing cancers associated with human papillomavirus (HPV). The two licensed prophylactic HPV vaccines protect against de novo infection with HPV-16 and HPV-18, which cause the majority of HPV-associated cancers. Currently, no vaccine efficacy data are available for persons with HIV infection. Nevertheless, some countries have implemented specific HPV vaccination recommendations for HIV-positive populations. To specifically recommend prophylactic HPV vaccination in people with HIV, the vaccines must be safe and immunogenic in immunosuppressed people at a high risk of HPV infection. This review aims to summarise the current knowledge from published HPV vaccine trials in HIV-infected populations, to compile scheduled and ongoing HPV vaccine trials with HIV-positive study populations and to extrapolate the relevant knowledge about HPV vaccine efficacy in HIV-negative populations to an HIV context. METHODS The databases PubMed, Scopus and ClinicalTrials.gov were searched for peer-reviewed articles and scheduled or ongoing clinical HPV vaccine trials enrolling HIV-positive persons. RESULTS Current data indicate that prophylactic HPV vaccines are safe and immunogenic in different HIV-positive populations (children, female adolescents, adults). Increased immunogenicity has been reported in persons on antiretroviral therapy compared with antiretroviral-naïve persons, whereas no clear association has been found between CD4(+) cell count at immunisation and vaccine response. Several scheduled and ongoing HPV vaccine trials aim to determine vaccine efficacy against disease endpoints in HIV-infected study populations. CONCLUSION Prophylactic HPV vaccination appears safe, immunogenic and, by extrapolation, likely to reduce HPV-associated cancer development among persons with HIV infection.
Rituximab induction immunotherapy for first-line low-tumor-burden follicular lymphoma: survival analyses with 7-year follow-up.

BACKGROUND The purpose of this study was to report long-term results of rituximab induction monotherapy in patients with low-tumor-burden follicular lymphoma (LTBFL). PATIENTS AND METHODS Of 49 first-line LTBFL patients who received weekly doses of rituximab (375 mg/m(2)), 46 have been followed with a long-term analysis of clinical and molecular responses. RESULTS Best clinical response (at any staging within a year following treatment) was 80%, 24 (52%) patients had complete or unconfirmed complete response, 13 (28%) had partial response and 9 (20%) had stable or progressive disease. Of 31 patients having a positive bcl2-JH rearrangement, 15 (48%) became negative following treatment. After 83.9 months of follow-up (95% confidence interval 6.4-92.8 months), the median progression-free survival is 23.5 months and overall survival (OS) is 91.7%. Five patients died (one progression, one myelodysplasia, one diffuse large B-cell lymphoma and two solid tumors). Seven patients (15%) are progression-free including five who are bcl2 informative. No unexpected long-term adverse event has been observed. CONCLUSION A significant proportion of patients remain progression-free 7 years after a single 4-dose rituximab treatment in first-line LTBFL. The 7-year overall survivalOS is very high in this selected population of patients.
Multiscale mechanics of graphene oxide and graphene based composite films

Multiscale Mechanics of Graphene Oxide and Graphene Based Composite Films Changhong Cao Doctor of Philosophy Graduate Department of Mechanical and Industrial Engineering University of Toronto 2016 The mechanical behavior of graphene oxide is length scale dependent: orders of magnitude different between the bulk forms and monolayer counterparts. Understanding the underlying mechanisms plays a significant role in their versatile application. A systematic multiscale mechanical study from monolayer to multilayer, including the interactions between layers of GO, can provide fundamental support for material engineering. In this thesis, an experimental coupled with simulation approach was used to study the multiscale mechanics of graphene oxide (GO) and the methods developed for GO study are proved to be applicable also to mechanical study of graphene based composites. GO is a layered nanomaterial comprised of hierarchical units whose characteristic dimension lies between monolayer GO (0.7 nm 1.2 nm) and bulk GO papers (≥ 1 μm). Mechanical behaviors of monolayer GO and GO nanosheets (10 nm100 nm) were comprehensively studied in this work. Monolayer GO was measured to have an average strength of 24.7 GPa,, orders of magnitude higher than previously reported values for GO paper and approximately 50% of the 2D intrinsic strength of pristine graphene. The huge discrepancy between the strength of monolayer GO and that of bulk GO paper motivated the study of GO at the intermediate length scale (GO nanosheets). Experimental results showed that GO nanosheets possess high strength in the gigapascal range. Molecular Dynamic simulations showed that the transition in the failure behavior from interplanar fracture to intraplanar fracture was responsible for the huge strength discrepancy between nanometer scale GO and bulk GO papers. Additionally, the interfacial shear strength between GO layers was found to be a key contributing factor to the distinct mechanical behavior among hierarchical units of GO. The understanding of the multiscale mechanics of GO is transferrable in heterogeneous layered nanomaterials, such as graphene-metal oxide based anode materials in Li-ion batteries. The novel methods developed in this work to study GO multilayered structures were also applied to study the mechanics of graphene-TiO2 composites. It was found that a critical thickness range of TiO2 deposition on graphene is required for the observed stiffness enhancement effect of graphene to influence the mechanical behavior of the composite.
Global optimization for the -norm model reduction problem

A branch and bound algorithm is proposed to solve the -norm model reduction problem for continuous and discrete-time linear systems, with convergence to the global optimum in a finite time. The lower and upper bounds in the optimization procedure are described by linear matrix inequalities (LMI). Also proposed are two methods with which to reduce the convergence time of the branch and bound algorithm: the first one uses the Hankel singular values as a sufficient condition to stop the algorithm, providing to the method a fast convergence to the global optimum. The second one assumes that the reduced model is in the controllable or observable canonical form. The -norm of the error between the original model and the reduced model is considered. Examples illustrate the application of the proposed method.
Thermal Inactivation of Desiccation-Adapted Salmonella spp. in Aged Chicken Litter

ABSTRACT Thermal inactivation of desiccation-adapted Salmonella spp. in aged chicken litter was investigated in comparison with that in a nonadapted control to examine potential cross-tolerance of desiccation-adapted cells to heat treatment. A mixture of four Salmonella serovars was inoculated into the finished compost with 20, 30, 40, and 50% moisture contents for a 24-h desiccation adaptation. Afterwards, the compost with desiccation-adapted cells was inoculated into the aged chicken litter with the same moisture content for heat treatments at 70, 75, 80, 85, and 150°C. Recovery media were used to allow heat-injured cells to resuscitate. A 5-log reduction in the number of the desiccation-adapted cells in aged chicken litter with a 20% moisture content required >6, >6, ∼4 to 5, and ∼3 to 4 h of exposure at 70, 75, 80, and 85°C, respectively. As a comparison, a 5-log reduction in the number of nonadapted control cells in the same chicken litter was achieved within ∼1.5 to 2, ∼1 to 1.5, ∼0.5 to 1, and <0.5 h at 70, 75, 80, and 85°C, respectively. The exposure time required to obtain a 5-log reduction in the number of desiccation-adapted cells gradually became shorter as temperature and moisture content were increased. At 150°C, desiccation-adapted Salmonella cells survived for 50 min in chicken litter with a 20% moisture content, whereas control cells were detectable by enrichment for only 10 min. Our results demonstrated that the thermal resistance of Salmonella in aged chicken litter was increased significantly when the cells were adapted to desiccation. This study also validated the effectiveness of thermal processing being used for producing chicken litter free of Salmonella contamination.
Online teaching and learning in higher education during COVID-19: international perspectives and experiences

The Model for Improvements in Learning Outcomes (MILO) is theoretically grounded and designed to intertwine didactics, pathophysiology and medicine with specific concepts important for learning. The aim was to describe supervisors ’ experiences of undergraduate nursing students ’ learning during clinical practice when using MILO. A qualitative and explorative design was used. Seventeen supervisors, thirteen women and four men from different departments at three hospitals in southern Sweden participated. After using the model, data were collected through four focus group interviews with open unstructured interview questions and analysed using inductive latent content analysis. Twelve subcategories, four generic subcategories and one main category emerged. The students developed a questioning approach and were more reflective, open and compliant. Twosomes enhanced learning. Specific documents generated structure and feelings of participation. The super-visors felt that taking the students ’ pre-understanding into account and a caring approach in the learning environment were valuable for enhanced learning. The students established a caring relationship with the patients and the patients ’ perspective became emphasized. Using MILO, intertwining between the natural and the professional became possible; enhanced learning in nursing skills together with a more caritative caring approach towards the patient was revealed. The need of compassion is discussed.