Miracle-dz/UniFAR-FTUs huggingface dataset:
Characteristics and outcomes of endoscopically resected colorectal cancers that arose from sessile serrated adenomas and traditional serrated adenomas

Background/Aims The efficacy and safety of endoscopic resection of colorectal cancer derived from sessile serrated adenomas or traditional serrated adenomas are still unknown. The aims of this study were to verify the characteristics and outcomes of endoscopically resected early colorectal cancers developed from serrated polyps. Methods Among patients who received endoscopic resection of early colorectal cancers from 2008 to 2011, cancers with documented pre-existing lesions were included. They were classified as adenoma, sessile serrated adenoma, or traditional serrated adenoma according to the baseline lesions. Clinical characteristics, pathologic diagnosis, and outcomes were reviewed. Results Overall, 208 colorectal cancers detected from 198 patients were included: 198 with adenoma, five with sessile serrated adenoma, and five with traditional serrated adenoma. The sessile serrated adenoma group had a higher prevalence of high-grade dysplasia (40.0% vs. 25.8%, P<0.001) than the adenoma group. During follow-up, local recurrence did not occur after endoscopic resection of early colorectal cancers developed from serrated polyps. In contrast, two cases of metachronous recurrence were detected within a short follow-up period. Conclusions Cautious observation and early endoscopic resection are recommended when colorectal cancer from serrated polyp is suspected. Colorectal cancers from serrated polyp can be treated successfully with endoscopy.
Complex systems and learning: empirical research, issues, and "seeing" scientific knowledge with new eyes

The purpose of this symposium is to move beyond speculations about how knowledge about complex systems might be important for students to understand to focus on empirical research into the learnability of these ideas. For example, do complex systems ideas represent learning challenges that are qualitatively different than learning other scientific knowledge? What are the differences in pre-conceptions students have about complex systems phenomena and more expert scientific ways of thinking in these areas? What are the profiles of successful and less successful ways of learning about complex systems conceptual perspectives? Can complex systems provide conceptual perspectives for cognitively "seeing" physical and social sciences subjects in new and interconnected ways? It is hoped the papers in this session will provide insights into these questions and other theoretical and research issues in the learning sciences.
Test and validity of the Brand Resonance Model’s

This study has the purpose to test and validate the Brand Resonance Model which is represented by a pyramid that contains cause and effect relationships between the constructs related to the brand (salience, image, performance, feeling, judgment and resonance), whose ultimate goal is to represent brand equity. Part of the research was carried out by a survey applied to hotel guests, at the end obtaining 302 questionnaires. Procedures were performed for data treatment, the constructs unidimensionality and reliability, convergent validity, discriminant validity and nomological validity. The results indicate that the Brand Resonance Model has nomological validity, since all the theoretical relations between the constructs were statistically significant. In terms of outcome the rational path - formed by performance and judgment - has a greater impact on brand resonance than the emotional path - image and feeling. The R 2 of brands’ resonance, the value obtained was 83%.
Constructing Verb Semantic Classes for French: Methods and Evaluation

In this paper, we study a reformulation, which is better adapted to NLP, of the alternation system developed for English by B. Levin. We have studied a set of 1700 verbs from which we explain how verb semantic classes can be built in a systematic way. The quality of the results w.r. t. semantic classifications such as WordNet is then evaluated.
Synchronous Replica Consistency Protocol with Notification and Response

Data grids provide geographically distributed resources for large-scale data-intensive applications that generate and share large data sets. Replication has been used to reduce the access latencies and ensure fault tolerance for such large scale data sharing. In spite of the advantages offered, Replication results in consistency problems if the applications are allowed to modify the data in an uncontrolled manner. In this paper a synchronous replica consistency protocol with notification and response is proposed. It deals with keeping the replicas coherent in an effective manner. It can increase the performance and will achieve optimal bandwidth utilization for file replications. The protocol is simulated in Java. It has been compared with other consistency protocols and the experimental results shows that the proposed scheme offers better performance in terms of replication time still maintaining the consistency among replicas.
Applying Cognitive Linguistics to Teaching English Prepositions: A Quasi-Experimental Study

This quasi-experimental study aimed to investigate the effectiveness of applying cognitive linguistics (CL) to teaching English prepositions. The pretest-posttest between-group design was adopted. The participants were selected according to their previous learning experiences, regular out-of-class exposure, eagerness for joining the study, and pretest results. The spatial and metaphorical meanings of the prepositions above, among, at, behind, beside, between, in, in front of, on and under were taught in 4 sessions of 90 minutes. The Cognitive Group received CLbased instructions and the Traditional Group received instructions based on vivid pictures and verbal explanations. The findings showed that the Cognitive Group outperformed the Traditional Group in the posttest in terms of both the spatial and metaphorical meanings. It can be said that CL-based instruction can help learners improve their knowledge of the prepositions better than the traditional pedagogical application. It is recommended that applying cognitive linguistics can help students of other languages master English prepositions. The participants’ responses to the questionnaires also assured research reliability and validity.
Riemann curvature-stretching coupling in dynamo torus laboratory and in UHF twisted plasma loops

A plasma loop twisted Riemannian model is applied to torus dynamos twisted flows it leading to a slow dynamo such as in Moebius strip dynamo, recently considered by Shukurov, Stepanov and Sokoloff [Phys. Rev. \textbf{E 78},025301,(2008)] to modelling Perm dynamo torus in liquid sodium. Since diffusion and advection (stretching), are competing effects for dynamo action, plasma resistivity term is shown to be proportional to loops Riemann curvature (folding). Shukurov et al, also showed that based on Ponomarenko dynamo, a broader torus channel produces a better dynamo. These results agree with Schekochihin et al [Phys Rev \textbf{E} (2002)] where random filamentary magnetic fields are strengthen by curvature. Analysis of spectrum of chaotic fast dynamos, shows that Riemann curvature acts as a damping, since growth magnetic field rate is inversely proportional to Riemann curvature. Comparison with general relativistic MHD dynamo equation, shows that the Ricci tensor, which is a contraction of the Riemann tensor also appears in the diffusion term. Curvature of plasma loop is ${{R^{1}}_{212}}|_{\textbf{Plasma}}\approx{5.6{\times}10^{-19}m^{-2}}$, while for Perm torus is certainly higher. Thus slow dynamos are favoured in dynamo laboratories rather than in plasma loops. It is shown that the curvature-stretching flux rope dynamo coupling energy, coincides with the minimum twist energy ${\epsilon}_{\textbf{twist}}\approx{10^{30}TeV}$ stored in flux ropes. Torus flux tubes around black-holes remain in the order of $2MeV$ and GBR are around $10^{52}TeV$. Since the ${R^{1}}_{212}$ is negative, inflexionary flux tubes fast dynamos may be responsible for this CME mechanism in UHF plasma loops.
Institutional Recognition in the Transnational Literary Field, 1955–2005

Contributing to research on social processes of cultural de-hierarchization, this article explores how critical recognition in elite newspapers is related to the recognition that authors receive from other agents in the literary field in the past half-century. We distinguish four types of institutional recognition: (a) long-term recognition in literary encyclopedias, (b) short-term recognition through literary awards, (c) recognition through bestseller list success, and (d) recognition through the prestige of publishers. Our study uses a sample of articles from 1955, 1975, 1995 and 2005 in French, German, Dutch and US elite papers (N=2,419), as well as further information on the extent to which fiction book authors discussed in the newspaper sample received the above forms of institutional recognition. We conduct cluster analysis to inductively establish how these forms of recognition are related, and multinomial logistic regression analysis to predict membership of clusters. Throughout the period 1955–2005 we consistently find three author categories: the unrecognized, the contemporary prestigious, and the historical prestigious. Countries differ, however, in the extent to which these categories are represented in newspaper literary coverage. Our analysis of factors determining membership of these clusters points to the lasting importance of symbolic capital, but also to the transnational nature of institutional recognition as local and international recognition show highly similar patterns.
Cerebral blood flow change during volatile induction in large-dose sevoflurane versus intravenous propofol induction: transcranial Doppler study

Background The impact of volatile induction using large-dose sevoflurane (VI-S) on cerebral blood flow has not been well investigated. The present study compared the changes in cerebral blood flow of middle cerebral artery using transcranial Doppler (TCD) during VI-S and conventional induction using propofol. Methods Patients undergoing elective lumbar discectomy were randomly allocated to receive either sevoflurane (8%, Group VI-S, n = 11) or target-controlled infusion of propofol (effect site concentration, 3.0 µg/ml; Group P, n = 11) for induction of anesthesia. The following data were recorded before and at 1, 2, and 3 min after commencement of anesthetic induction (T0, T1, T2, and T3, respectively): mean velocity of the middle cerebral artery (VMCA) by TCD, mean blood pressure (MBP), heart rate, bispectral index score (BIS) and end-tidal CO2 (ETCO2). Changes in VMCA and MBP from their values at T0 (ΔVMCA and ΔMBP) at T1, T2, and T3 were also determined. Results BISs at T1, T2 and T3 were significantly less than that at T0 in both groups (P < 0.05). ΔVMCA in Group VI-S at T2 and T3 (18.1% and 12.4%, respectively) were significantly greater than those in Group P (-7.6% and -19.8%, P = 0.006 and P < 0.001, respectively), whereas ETCO2 and ΔMBP showed no significant intergroup difference. Conclusions VI-S using large-dose sevoflurane increases cerebral blood flow resulting in luxury cerebral flow-metabolism mismatch, while conventional propofol induction maintains cerebral flow-metabolism coupling. This mismatch in VI-S may have to be considered in clinical application of VI-S.
Potential Immune Modularly Role of Glycine in Oral Gingival Inflammation

Gingival epithelial cells (GECs) represent a physical barrier against bacteria and are involved in the processes of innate immunity. Recently, an anti-inflammatory and immune-modulatory effect of the amino acid glycine has been demonstrated. However, there is only little information about the immune-modulatory effects of glycine in oral tissues. This study aimed to investigate the existence and role of the glycine receptor in gingival tissue analyzing tissues/cells from extracted human molars via immunohistochemical analysis. In vitro, GECs were challenged by inflammatory conditions with IL-1β alone or in combination with glycine and analyzed for cytokine expression of IL6/IL8 via real-time PCR. On protein level, the effect of nuclear translocalization of NFκB protein p65 was analyzed using immunofluorescence analysis. A distinct proof of the GlyR in oral gingival tissue and keratinocytes could be demonstrated. Isolated challenge of the keratinocytes with IL-1β as well as with glycine resulted in an upregulation of IL6 and IL8 mRNA expression and activation of NFκB pathway. The presence of glycine in combination with the inflammatory stimulus led to a significant decrease in inflammatory parameters. These results indicate a possible anti-inflammatory role of glycine in gingival inflammation and encourage further research on the utility of glycine in the prevention or therapy of inflammatory periodontitis.
Robust Observer Design for a Class of Switched Systems

The main contribution of this paper is an algorithm for the design of state observers for a class of switched systems. The state observers designed allow for switching among linear parameter varying (LPV) systems affected by structured uncertainty and unmeasurable input/output disturbances. The proposed observers have guaranteed performance even during the switching transient, and "mitigate" the effect of structured uncertainty and unmeasured disturbances. Moreover, it is shown that the observer design problem can be reduced to a convex optimization problem. Finally, a numerical example is presented which shows the efficacy of the proposed approach
The Phenomenal Basis of Intentionality

Some mental states seem to be "of" or "about" things or to "say" something. For example, a thought might represent that grass is green, and a visual experience might represent a blue cup. This is intentionality. The aim of this book is to explain this phenomenon. Once we understand intentionality as a phenomenon to be explained, rather than a posit in a theory explaining something else, we can see that there are glaring empirical and in-principle difficulties with currently popular tracking and functional role theories of intentionality, which aim to account for intentionality in terms of tracking relations and functional roles. This book develops an alternative theory, the phenomenal intentionality theory (PIT), on which the source of intentionality is none other than phenomenal consciousness, the subjective, felt, or qualitative aspect of mental life. While PIT avoids the problems that plague tracking and functional role theories, it faces its own challenges in accounting for the rich and complex contents of thoughts and the contents of nonconscious states. In responding to these challenges, this book proposes a novel version of PIT, one on which all intentionality is phenomenal intentionality, though we in some sense represent many non-phenomenal contents by ascribing them to ourselves. This book further argues that phenomenal consciousness is an intrinsic feature of mental life, resulting in a view that is radically internalistic in spirit: Our phenomenally represented contents are literally in our heads, and any non-phenomenal contents we in some sense represent are expressly targeted by us.
Long-Run Productivity Risk: A New Hope for Production-Based Asset Pricing?

The examination of the intertemporal distribution of US productivity risk suggests that the conditional mean of productivity growth is an important determinant of macro quantities and asset prices. After establishing this empirical link, I rationalize it in a production economy featuring long-run productivity risk, Epstein and Zin (1989) preferences, and investment frictions. Both convex capital adjustment costs and convex reallocation costs across consumption and investment produce an annual equity premium as sizeable as in the data.
Observations on Small Mammals Recovered from Owl Pellets from Nebraska

Mammalian remains from owl pellet material collected in 24 Nebraska counties were examined, A total of 1262 individual mammals was identified from all owl pellet material and included 19 identifiable species and 21 total genera. The most commonly consumed prey by owls across the state were Microtus (41 % of identifiable prey material), followed by Peromyscus (18%), and Reithrodontomys (11%). Significant locality information for the northern grasshopper mouse (Onychomys leucogaster), the southern bog lemming (Synaptomys cooperi), and the meadow vole (Microtus pennsylvanicus) are reported.
The 1.6 Å Crystal Structure of Pyranose Dehydrogenase from Agaricus meleagris Rationalizes Substrate Specificity and Reveals a Flavin Intermediate

Pyranose dehydrogenases (PDHs) are extracellular flavin-dependent oxidoreductases secreted by litter-decomposing fungi with a role in natural recycling of plant matter. All major monosaccharides in lignocellulose are oxidized by PDH at comparable yields and efficiencies. Oxidation takes place as single-oxidation or sequential double-oxidation reactions of the carbohydrates, resulting in sugar derivatives oxidized primarily at C2, C3 or C2/3 with the concomitant reduction of the flavin. A suitable electron acceptor then reoxidizes the reduced flavin. Whereas oxygen is a poor electron acceptor for PDH, several alternative acceptors, e.g., quinone compounds, naturally present during lignocellulose degradation, can be used. We have determined the 1.6-Å crystal structure of PDH from Agaricus meleagris. Interestingly, the flavin ring in PDH is modified by a covalent mono- or di-atomic species at the C(4a) position. Under normal conditions, PDH is not oxidized by oxygen; however, the related enzyme pyranose 2-oxidase (P2O) activates oxygen by a mechanism that proceeds via a covalent flavin C(4a)-hydroperoxide intermediate. Although the flavin C(4a) adduct is common in monooxygenases, it is unusual for flavoprotein oxidases, and it has been proposed that formation of the intermediate would be unfavorable in these oxidases. Thus, the flavin adduct in PDH not only shows that the adduct can be favorably accommodated in the active site, but also provides important details regarding the structural, spatial and physicochemical requirements for formation of this flavin intermediate in related oxidases. Extensive in silico modeling of carbohydrates in the PDH active site allowed us to rationalize the previously reported patterns of substrate specificity and regioselectivity. To evaluate the regioselectivity of D-glucose oxidation, reduction experiments were performed using fluorinated glucose. PDH was rapidly reduced by 3-fluorinated glucose, which has the C2 position accessible for oxidation, whereas 2-fluorinated glucose performed poorly (C3 accessible), indicating that the glucose C2 position is the primary site of attack.
VEAL: Virtualized Execution Accelerator for Loops

Performance improvement solely through transistor scaling is becoming more and more difficult, thus it is increasingly common to see domain specific accelerators used in conjunction with general purpose processors to achieve future performance goals. There is a serious drawback to accelerators, though: binary compatibility. An application compiled to utilize an accelerator cannot run on a processor without that accelerator, and applications that do not utilize an accelerator will never use it. To overcome this problem, we propose decoupling the instruction set architecture from the underlying accelerators. Computation to be accelerated is expressed using a processorpsilas baseline instruction set, and light-weight dynamic translation maps the representation to whatever accelerators are available in the system. In this paper, we describe the changes to a compilation framework and processor system needed to support this abstraction for an important set of accelerator designs that support innermost loops. In this analysis, we investigate the dynamic overheads associated with abstraction as well as the static/dynamic tradeoffs to improve the dynamic mapping of loop-nests. As part of the exploration, we also provide a quantitative analysis of the hardware characteristics of effective loop accelerators. We conclude that using a hybrid static-dynamic compilation approach to map computation on to loop-level accelerators is an practical way to increase computation efficiency, without the overheads associated with instruction set modification.
Two Types of X-Ray Spectra in Cataclysmic Variables

We present Chandra high-energy transmission grating spectra of seven cataclysmic variables. We find that they divide unambiguously into two distinct types. Spectra of the first type are remarkably well fitted by a simple cooling flow model, which assumes only steady-state isobaric radiative cooling. The maximum temperature, kTmax, and the normalization, which provides a highly precise measurement of the accretion rate, are the only free parameters of this model. Spectra of the second type are grossly inconsistent with a cooling flow model. They instead exhibit a hard continuum and show strong H-like and He-like ion emission but little Fe L-shell emission, which is consistent with expectations for line emission from a photoionized plasma. Using a simple photoionization model, we argue that the observed line emission for these sources can be driven entirely by the hard continuum. The physical significance of these two distinct types of X-ray spectra is also explored.
Autism stigma and the role of ethnicity and culture

This is a highly prevalent and dangerous problem. Redman et al (2009) reported that only 15% of autistic adults in the UK are in full-time employment, while 79% of those on incapacity benefit say they want to work. Further, an independent survey commissioned by The National Autistic Society in 2012 revealed that more than a third of those who have secured employment experienced workplace discrimination or bullying (Bancroft et al, 2012).
Tourists' intention to visit heritage hotels at George Town World Heritage Site

ABSTRACT George Town, Penang, has always been one of the most popular destinations among Malaysian and international tourists. In 2008, George Town was accorded a listing as a UNESCO World Heritage Site (WHS). With the listing, increasing tourist arrivals and intentions to visit heritage hotels have been very promising in recent years, prompting the emergence of the adaptive reuse of heritage buildings into heritage hotels. In line with this development, this study examines the effects of perceived price, experience quality, prior knowledge, perceived authenticity, and social influence on tourists’ intention to visit heritage hotels at the George Town WHS, Penang, with perceived value as a mediator. The findings indicate that perceived price, experience quality, prior knowledge, perceived authenticity, social influence and perceived value exert positive and significant effects on tourists’ intention to visit heritage hotels. The study also determines the mediating effect of perceived value on the relationships between independent variables and the intention to visit heritage hotels. This study provides an in-depth understanding of the attributes that affect tourists’ intention to visit heritage hotels at the George Town WHS and helps the owners and operators of heritage hotels to formulate future strategies in designing and promoting their services.