Miracle-dz/UniFAR-FTUs huggingface dataset:
[Epidemiology of adverse events in the neonatal unit of a regional public hospital in Argentina].

UNLABELLED Patient safety is one of the critical dimensions of quality of care. OBJECTIVE To describe the epidemiology of adverse event (AE) in the neonatal unit of the Hospital Penna in Bahía Blanca, in 2006. METHODOLOGY Cross-sectional study based on a two-stage-chart-review methodology. 1st stage: screening through indicators that allow the identification of hospitalizations with higher risk of AE; 2nd stage: AE confirmation (assessment of the existence, type, category, preventability and consequences of AE). RESULTS 484 charts were included. Frequency of AE: 146 in 82 hospitalizations (16.9%) and an average of 3 out of 10 hospitalizations. The most frequent AE were: nosocomial infections; catheter-use related events and extubations. The probability of AE was inversely associated with weight at birth and gestational age and directly related to length of stay (the longer the stay, the higher the probability). It was also positively associated with admission to the intensive care unit. CONCLUSION The neonatal population, especially premature newborns, constitutes a group of high vulnerability to present AE. Most of these events are potentially preventable, which highlights the need of implementing effective interventions oriented to improve patient safety and quality of care.
Construction of Manifolds of Positive Ricci Curvature with Big Volume and Large Betti Numbers

It is shown that a connected sum of an arbitrary number of complex projective planes carries a metric of positive Ricci curvature with diameter one and, in contrast with the earlier examples of Sha–Yang and Anderson, with volume bounded away from zero. The key step is to construct complete metrics of positive Ricci curvature on the punctured complex projective plane, which have uniform euclidean volume growth and almost contain a line, thus showing topological instability of the splitting theorem of Cheeger–Gromoll, even in the presence of the lower volume bound. In the absence of such a bound, the topological instability was earlier shown by Anderson; metric stability holds, even without the volume bound, by the recent work of Colding–Cheeger.
Evaluation of ICT literacy differences in trainee student teachers from the view of sexuality

Purpose – The aim of this paper is to evaluate ICT literacy differences in trainee student teachers from the view of sexuality.Design/methodology/approach – In the research, sender differences in self‐reported ICT experience and ICT literacy among first year graduate trainee teachers were investigated. The questionnaires were made available in two forms: printed and online. Also, dynamic model of ICT literacy was employed. Three main components of aspiring teachers' ICT literacy were covered: present general problem‐solving and technical ICT capabilities; situational and longitudinal sustainability; and transferability of ICT capabilities into future professional domain.Findings – Results show no significant differences were found between females' and males' previous experience with ICT. However, males on average worked with computers significantly more hours per week than females. Significant differences between males' and females' technical ICT capabilities and situational and longitudinal sustainabilit.
Job Conditions and Personality: A Longitudinal Assessment of Their Reciprocal Effects

In earlier work, we assessed a longitudinal causal model of the reciprocal effects of the substative complexity of work and intellectual flexibility. In this paper, we greatly expand the causal model to consider sumultaneously several structural imperatives of the job and three major dimensions of personality-ideational flexibility, a self directed orientation to self and society, and a sense of distress. The analysis demonstrates that the structural imperatives of the job affect personality. Self-directed work leads to ideational flexibility and to a self-directed orientation to self and society; oppressive working conditions lead to distress. These findings strongly support a learning generalization model. Personality, in turn, has important consequences for an individual's place in the job structure and in the system of social stratification. In particular, both ideational flexibility and a self-directed orientation lead, over time, to more responsible jobs that allow greater latitude for occupational self-direction.
Exploring Personal Teaching Metaphors in Preservice Teacher Education

The use of metaphor analysis to engage preservice students in an examination of their concep tions of teaching is described. The evolution of three students' metaphors as they proceeded through student teaching illustrates the value of metaphor analysis in helping student teachers maintain their idealism as they confront the realities of classroom teaching. Problems arising from metaphor analysis, including the tendency of some students to offer glib or superficial analyses and the need to combine metaphor analysis with the writing of education-related life histories and critical analyses of the school context, are discussed.
Media uploading systems with hard deadlines

This paper introduces a new uploading system that automatically uploads multimedia files to a centralized server given client hard deadlines. Unlike systems supporting downloading applications such as video streaming and file sharing, systems that support uploading applications have received relatively little attention in the past decade. While not popularly studied, uploading systems with hard deadlines have several important applications in practice. For instance, such systems can be used in hospitals to gather videos generated from medical devices from various operating rooms for post-procedure analysis and in law enforcement to collect video recordings from police cars during routine patrolling. In this paper, we study an uploading system with hard deadlines in detail. We define a suitable performance measure for the system and evaluate the system performance via analysis and simulations.
T cells and fibroblasts in affected extraocular muscles in early and late thyroid associated ophthalmopathy

AIM To determine whether there are differences in the lymphocytic cell infiltrate present in affected extraocular muscles (EOM) during early and late stages of thyroid associated ophthalmopathy (TAO). METHODS 17 biopsies of affected EOMs were collected from two groups of TAO patients (n=14): the first of five patients with early, active TAO, and the second of nine patients with late, inactive TAO. The control group was of EOM biopsies taken from 14 non-TAO patients undergoing squint surgery. Immunohistochemical analysis was undertaken using the relevant monoclonal antibodies and an avidin-biotin system and the three groups compared. RESULTS Both CD4+ and CD8+ T cells were found in the cellular infiltrate in early, active TAO specimens which were much less evident either in late, inactive stage disease or in control tissue. There was also a significant increase in both CD45RO+ and CD45RB+ cells and macrophages in early TAO compared with the others. Increased expression of HLA-DR antigen by interstitial cells including fibroblasts was detected in both early and late disease but the EOM fibres remained morphologically intact and did not express MHC class II antigens at any time. CONCLUSION These results demonstrate that T cells are only significantly present in early disease but increased HLA-DR antigen expression on fibroblasts is observed at all stages. This suggests that T cells are much more involved in the early than the later stages of the disease process and that early activation of fibroblasts occurs. Early intervention with immunosuppressive therapy to downregulate cytokine production by T cells may significantly influence the sequelae caused by EOM fibrosis.
WiscKey

We present WiscKey, a persistent LSM-tree-based key-value store with a performance-oriented data layout that separates keys from values to minimize I/O amplification. The design of WiscKey is highly SSD optimized, leveraging both the sequential and random performance characteristics of the device. We demonstrate the advantages of WiscKey with both microbenchmarks and YCSB workloads. Microbenchmark results show that WiscKey is 2.5 × to 111 × faster than LevelDB for loading a database (with significantly better tail latencies) and 1.6 × to 14 × faster for random lookups. WiscKey is faster than both LevelDB and RocksDB in all six YCSB workloads.
Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

The two main drivers of Alzheimer's disease (AD), amyloid-β (Aβ) and hyperphosphorylated Tau (p-Tau) oligomers, cooperatively accelerate AD progression, but a hot debate is still ongoing about which of the two appears first. Here we present preliminary evidence showing that Tau and p-Tau are expressed by untransformed cortical adult human astrocytes in culture and that exposure of such cells to an Aβ42 proxy, Aβ25−35, which binds the calcium-sensing receptor (CaSR) and activates its signaling, significantly increases intracellular p-Tau levels, an effect CaSR antagonist (calcilytic) NPS 2143 wholly hinders. The astrocytes also release both Tau and p-Tau by means of exosomes into the extracellular medium, an activity that could mediate p-Tau diffusion within the brain. Preliminary data also indicate that exosomal levels of p-Tau increase after Aβ25−35 exposure, but remain unchanged in cells pre-treated for 30-min with NPS 2143 before adding Aβ25−35. Thus, our previous and present findings raise the unifying prospect that Aβ•CaSR signaling plays a crucial role in AD development and progression by simultaneously activating (i) the amyloidogenic processing of amyloid precursor holoprotein, whose upshot is a surplus production and secretion of Aβ42 oligomers, and (ii) the GSK-3β-mediated increased production of p-Tau oligomers which are next released extracellularly inside exosomes. Therefore, as calcilytics suppress both effects on Aβ42 and p-Tau metabolic handling, these highly selective antagonists of pathological Aβ•CaSR signaling would effectively halt AD's progressive spread preserving patients' cognition and life quality.
Congruence between social values and implicit motives: effects on life satisfaction across three cultures

This study examines the relationship between implicit motives for intimacy‐affiliation and power, explicit value orientations, and life satisfaction. The Satisfaction With Life Scale, the Schwartz Value Survey, and a bias‐free TAT‐type picture‐story‐test were administered to 319 adult participants in Cameroon, Costa Rica, and Germany. The stories were coded for motive imagery reflecting needs for intimacy‐affiliation and power. Based on motives associated with the domain intimacy‐affiliation, the results revealed that an alignment of implicit motives and self‐attributed values is associated with an enhanced life satisfaction across cultures. In contrast, no such relationship could be found for motives and values associated with the domain of power. Copyright © 2006 John Wiley & Sons, Ltd.
Selective Synaptic Distribution of Kainate Receptor Subunits in the Two Plexiform Layers of the Rat Retina

The synaptic localization of the kainate receptor subunits GluR6/7 and KA2 and of the ionotropic glutamate receptor subunits δ1/2 was studied in the rat retina using receptor-specific antisera. GluR6/7 and KA2 were present in both synaptic layers of the retina: the inner plexiform layer (IPL) and the outer plexiform layer (OPL). The localization of δ1/2 was restricted to the IPL. Detailed ultrastructural examination showed that in the OPL GluR6/7 was localized in horizontal cell processes postsynaptic to both rod spherules and cone pedicles. It was always only one of the two invaginating horizontal cell processes at the photoreceptor synapses labeled for GluR6/7. KA2 in the OPL was found only postsynaptic to cone pedicles and never postsynaptic to rod spherules. The KA2-labeled processes made flat contacts with the cone pedicles, suggesting they are the dendrites of OFF bipolar cells. In the IPL the different receptor subunits were localized postsynaptically to ribbon synapses of both rod and cone bipolar cells. As a rule, only one of the two postsynaptic elements at the bipolar cell dyad was stained for each of the receptor subunits examined. The selective and heterogeneous distribution of these receptors at the ribbon synapses of the OPL and IPL suggests a high degree of differential processing of the glutamatergic signals.
Effectiveness of a selamectin spot-on formulation in rabbits with sarcoptic mange

LEPORINE sarcoptic mange is a relatively rare, highly contagious and pruritic skin disease with zoonotic potential ([Hillyer 1997][1], [Scott and others 2001][2], [Meredith 2006][3]). The causative agent, Sarcoptes scabiei var cuniculi inhabits the epidermis of sparsely haired areas of the body,
The construct validity of vigor and its antecedents: A qualitative study

Our first objective in this qualitative study was to validate the conceptualization of vigor as comprising physical strength, emotional energy and cognitive liveliness. Our second objective was to explore vigor's work-related antecedents. We applied theme analysis to the contents of interviews held with 38 randomly selected employees. The results clearly supported the three-component conceptualization of vigor as most employees (77%) related to vigor as a multifaceted variable. The most frequent work-related antecedents of vigor that emerged from the interviews were meaningful interactions with others, coping with challenging situations, and achieving success on a project. By superimposing the Job Characteristics Model on these qualitative findings, we inferred from the items describing vigor's antecedents that job significance, supervisory feedback, and job identity were the most frequently mentioned antecedents of vigor at work. Additionally, we found indications of a spillover effect of vigor from the home to the work domains.
Guidelines in lower‐middle income countries

Guidelines include recommendations intended to optimize patient care; used appropriately, they make healthcare consistent and efficient. In most lower‐middle income countries (LMICs), there is a paucity of well‐designed guidelines; as a result, healthcare workers depend on guidelines developed in Higher Income Countries (HICs). However, local guidelines are more likely to be implemented because they are applicable to the specific environment; and consider factors such as availability of resources, specialized skills and local culture. If guidelines developed in HICs are to be implemented in LMICs, developers need to incorporate local experts in their development. Involvement of local stakeholders may improve the rates of implementation by identifying and removing barriers to implementation in LMICs. Another option is to encourage local experts to adapt them for use in LMICs; these guidelines may recommend strategies different from those used in HICs, but will be aimed at achieving the best practicable standard of care. Infrastructural deficits in LMICs could be improved by learning from and building on the successful response to the human immunodeficiency virus/acquired immunodeficiency syndrome pandemic through interactions between HICs and LMICs. Similarly, collaborations between postgraduate medical colleges in both HICs and LMICs may help specialist doctors training in LMICs develop skills required for guideline development and implementation.
Beyond the observer’s paradox: the audio-recorder as a resource for the display of identity

Instead of viewing the ‘observer’s paradox’ or the presence of ‘tape-affected speech’ as a methodological problem that spoils ‘natural’ data, in this article, I advocate exploring the opportunities that a recorder offers to research study participants, and the insights tape-affected speech gives to researchers. In my discourse analysis of the week-long self-audio-recorded discourse of members of four American families, I draw on the notions of ‘frame’ and ‘footing’ to uncover the various ways the recorder is conceptualized and oriented to in interaction—as an object and a person, and in literal and playful ways—and demonstrate how participants use the recorder as a resource for identity work in interaction. Analysis reveals how recording shapes the interactions that constitute ‘data’ and how study participants manipulate the presence of the recorder to display identities.
TLR9 expression and secretion of LIF by prostate cancer cells stimulates accumulation and activity of polymorphonuclear MDSCs

Proinflammatory signals promote prostate tumorigenesis and progression, but their origins and downstream effects remain unclear. We recently demonstrated that the expression of an innate immune receptor, TLR9, by prostate cancer cells is critical for their tumor‐propagating potential. We investigated whether cancer cell–intrinsic TLR9 signaling alters composition of the prostate tumor microenvironment. We generated Ras/Myc (RM9) and Myc‐driven (Myc‐CaP) prostate cancer cells expressing the tetracycline‐inducible gene Tlr9 (Tlr9ON) or the control LacZ (LacZON). When engrafted into mice and treated with tetracycline, Tlr9ON, but not LacZON, tumors showed accelerated growth kinetics compared with tumors in PBS‐treated mice. Tlr9 upregulation in cancer cells triggered the selective accumulation of CD11b+Ly6GHILy6CLO myeloid cells, phenotypically similar to PMN‐MDSCs. The PMN‐MDSCs from tetracycline‐treated RM9‐Tlr9ON tumors increased the immunosuppressive activity of the STAT3 transcription factor, thereby more potently inhibiting T cell proliferation. We identified LIF, an IL‐6‐type cytokine and STAT3 activator, as a potential mediator of crosstalk between TLR9‐expressing prostate cancer cells and PMN‐MDSCs. Antibody‐mediated LIF neutralization reduced the percentage of tumor‐infiltrating PMN‐MDSCs and inhibited tumor growth in mice. The clinical relevance of LIF is confirmed by the correlation between TLR9 and LIF expression in prostate cancer specimens. Furthermore, blood samples from patients with prostate cancer showed elevated levels of LIF and high LIFR expression on circulating PMN‐MDSCs. Our results suggest that TLR9+ prostate cancers promote immune evasion via LIF‐mediated expansion and activation of PMN‐MDSCs. Finally, targeting TLR9/LIF/STAT3 signaling using oligonucleotide‐based inhibitors, such as CpG‐STAT3dODN, can offer new opportunities for prostate cancer immunotherapy.
Long-term socialisation goals and the construction of infants’ social networks among middle class Anglo and Puerto Rican mothers

This study examined the relation between mothers’ long-term socialisation goals and the social networks they construct for their infants. Middle class Anglo (n = 32) and Puerto Rican (n = 28) mothers were interviewed regarding: (a) their long-term socialisation goals; (b) how often their infants’ typically have contact with friends and family members; and (c) specific family circumstances which might influence contact with relatives, including geographic distance, maternal employment status, and child care arrangements. Study results indicated that mothers’ long-term socialisation goals were correlated with the type and frequency of social contacts they structured for their infants. Moreover, limited evidence was found for the influence of group membership on frequency of contact with relatives, despite individual variations in family circumstances. Results are interpreted as illuminating one aspect of the interface between cultural beliefs and socialisation practices within the constructs of individualism/sociocentrism.
Elbow Room: The Varieties of Free Will Worth Wanting

Anyone who has wondered if free will is just an illusion or has asked 'could I have chosen otherwise? ' after performing some rash deed will find this book an absorbing discussion of an endlessly fascinating subject. Daniel Dennett, whose previous books include Brainstorms and (with Douglas Hofstadter) The Mind's I, tackles the free will problem in a highly original and witty manner, drawing on the theories and concepts of several fields usually ignored by philosophers; not just physics and evolutionary biology, but engineering, automata theory, and artificial intelligence. In Elbow Room, Dennett shows how the classical formulations of the problem in philosophy depend on misuses of imagination, and he disentangles the philosophical problems of real interest from the "family of anxieties' they get enmeshed in - imaginary agents, bogeymen, and dire prospects that seem to threaten our freedom. Putting sociobiology in its rightful place, he concludes that we can have free will and science too. Elbow Room begins by showing how we can be "moved by reasons" without being exempt from physical causation. It goes on to analyze concepts of control and self-control-concepts often skimped by philosophers but which are central to the questions of free will and determinism. A chapter on "self-made selves" discusses the idea of self or agent to see how it can be kept from disappearing under the onslaught of science. Dennett then sees what can be made of the notion of acting under the idea of freedomdoes the elbow room we think we have really exist? What is an opportunity, and how can anything in our futures be "up to us"? He investigates the meaning of "can" and "could have done otherwise," and asks why we want free will in the first place.We are wise, Dennett notes, to want free will, but that in itself raises a host of questions about responsibility. In a final chapter, he takes up the problem of how anyone can ever be guilty, and what the rationale is for holding people responsible and even, on occasion, punishing them. Elbow Room is an expanded version of the John Locke Lectures which Dennett gave at Oxford University in 1983.
Art Therapy for Groups: A Handbook of Themes and Exercises

Part 1: Art Therapy Groups. Art Therapy and Groupwork. Running a Group. Recording, Evaluation and Evidence-based Practice. Learning from Problems in Groups. An Example in Detail: The 'Friday Group'. Examples of Groups. Starting Points for Specific Client Groups. Part 2: Themes and Exercises. Introduction, Classification of Themes and Exercises. Checklist of Themes and Exercises. Warm-up Activities. Media Exploration. Concentration, Dexterity and Memory. General Themes. Self-perceptions. Family Relationships. Working in Pairs. Group Paintings. Group Interactive Exercises. Guided Imagery, Visualisations, Dreams and Meditations. Links with Other Arts. Media Cross-reference. Media Notes. Resources.
Modes of communication during jazz improvisation

This study investigated modes of communication adopted by six student jazz musicians during rehearsal and performance. Six one-hour rehearsal sessions and a performance were observed and videotaped for analysis. Results revealed six modes of communication that formed two main categories, verbal and non-verbal, each containing three distinct modes of communication: instruction, cooperation and collaboration. Non-verbal collaborative mode displayed empathetic attunement, which is a vehicle for empathetic creativity. Empathetic creativity is a theoretical concept proposed by the author based on the concept of empathetic intelligence (Arnold, 2003, 2004). Practical applications of empathetic creativity are discussed with reference to music education, focusing on evaluation of individual contribution to group creative performances.