Miracle-dz/UniFAR-FTUs huggingface dataset:
Parental Perceptions of the Parent-Therapist Relationship: Effects on Outcomes of Early Intervention

ABSTRACT Federal law mandates that early intervention (EI) programs provide care using a family-centered model. The purpose of this preliminary study was to investigate (a) the relationship that develops between physical therapists and parents during EI and (b) a possible link between this relationship and EI outcomes. Thirty-nine parents of children with identified motor delays participated in this study. Data were collected through use of standardized measures and surveys developed for the study. Results of one-way ANOVA indicated that parents in the collaborative typology experienced significantly less stress and higher levels of parenting competence than parents in the distant typology. Parents in the collaborative typology also reported their EI program was more family centered. Child outcomes as related to the relationship typology were not significant, but the trend observed suggests further study is warranted. These findings suggest that measuring two specific relationship characteristics, satisfaction and control, may be helpful when trying to conceptualize and evaluate the parent-therapist relationship. This relationship evaluation may provide guidance to clinicians seeking to develop more collaborative relationships with families.
Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition

The purpose of this study was to use liquid chromatography-mass spectrometry (LC-MS) with XCMS for a quantitative metabolomic analysis of UM1 and UM2 oral cancer cells after knockdown of metabolic enzyme adenylate kinase 2 (AK2) or phosphorylate glycerol kinase 1 (PGK1). UM1 and UM2 cells were initially transfected with AK2 siRNA, PGK1 siRNA or scrambled control siRNA, and then analyzed with LC-MS for metabolic profiles. XCMS analysis of the untargeted metabolomics data revealed a total of 3200-4700 metabolite features from the transfected UM1 or UM2 cancer cells and 369-585 significantly changed metabolites due to AK2 or PGK1 suppression. In addition, cluster analysis showed that a common group of metabolites were altered by AK2 knockdown or by PGK1 knockdown between the UM1 and UM2 cells. However, the set of significantly changed metabolites due to AK2 knockdown was found to be distinct from those significantly changed by PGK1 knockdown. Our study has demonstrated that LC-MS with XCMS is an efficient tool for metabolomic analysis of oral cancer cells, and knockdown of different genes results in distinct changes in metabolic phenotypes in oral cancer cells.
Characterization of Prototype Foamy Virus Gag Late Assembly Domain Motifs and Their Role in Particle Egress and Infectivity

ABSTRACT Foamy viruses (FV) are unusual among retroviruses since they require both Gag and Env structural proteins for particle egress. Recently significant progress has been made towards the mechanistic understanding of the viral release process, in particular that of retroviruses, and the viral domains and cellular pathways involved. However little is currently known about domains of FV structural proteins and cellular proteins engaged in this process. By mutational analysis of sequence motifs in prototype FV (PFV) Gag, bearing homology to known late assembly (L) domains, a PSAP motif with L domain function that was functionally interchangeable by heterologous L domains was identified. In contrast the inactivation of a PPPI motif had no significant influence on PFV particle release, although mutant viral particles displayed reduced infectivity. Similarly mutation of an evolutionary conserved YXXL motif revealed no classical L-domain function but resulted in release of noninfectious viruslike particles. Biochemical and electron microscopy analysis demonstrated that these mutant particles incorporated all viral structural proteins but contained aberrantly capsid structures, suggesting a role in capsid assembly for this PFV Gag sequence motif. In line with the mutational analysis, overexpression of dominant negative (DN) mutants and wild-type TSG101 but not the DN mutant of AIP-1/ALIX reduced PFV particle release and infectivity. Furthermore, DN mutants of Vps4A, Vps4B, and CHMP3 inhibited PFV egress and infectivity. Taken together these results demonstrate that PFV, like other viruses, requires components of the vacuolar protein sorting (VPS) machinery for egress and enters the VPS pathway through interaction with TSG101.
Soluble CXCL16 Predicts Long-Term Mortality in Acute Coronary Syndromes

Background— CXCL16/SR-PSOX is an interferon-γ–regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogenic inflammatory response. We hypothesized that soluble CXCL16 concentrations are associated with long-term outcome in patients with acute coronary syndromes. Methods and Results— We assessed the association between circulating CXCL16 levels obtained within 24 hours after admission and time to death in 1351 patients (median age 67 years, 30% female) with a diagnosis of unstable angina, non–ST-segment–elevation myocardial infarction, or ST-segment–elevation myocardial infarction. During a median follow-up time of 81 months, 377 patients died. Increased levels of CXCL16 were prognostically unfavorable; the fourth versus first quartile was associated with higher risk of death (hazard ratio 2.1; 95% CI 1.6 to 2.8; P<0.0001), triple risk of developing heart failure (hazard ratio 3.0; 95% CI 1.8 to 5.1; P<0.0001), and a doubling of the risk of rehospitalization for myocardial infarction (hazard ratio 2.1; 95% CI 1.3 to 3.3; P=0.002). After adjustment for conventional risk markers, logarithmically transformed CXCL16 level remained a strong independent indicator of long-term mortality (hazard ratio 1.21; 95% CI 1.09 to 1.36 per 1 SD increase in CXCL16; P=0.0006) and congestive heart failure development (hazard ratio 1.25; 95% CI 1.05 to 1.48; P=0.01). In a subsample of 714 patients, after further adjustment for troponin T, high-sensitive C-reactive protein, pro–B-type natriuretic peptide, and left ventricular ejection fraction, CXCL16 still provided significant additional prognostic information on mortality (hazard ratio 1.21; 95% CI 1.02 to 1.42 per 1 SD increase in CXCL16; P=0.02). Conclusions— In patients with an acute coronary syndrome, CXCL16 levels obtained within 24 hours of admission are associated with long-term mortality after adjustment for other risk factors.
Analysis of Internet topology data

Discovering Internet topology is important for analyzing routing protocols and Internet robustness and resilience. Recent research results dealing with Internet topology, such as the discovery of power-laws and the application of normalized Laplacian analysis to Internet topology data, have increased the need for more complete datasets and their more rigorous interpretations. In this paper, we examine datasets from two sources: Route Views and RIPE. We show that each dataset may have a geographical bias and, consequently, consist of distinct routes. Furthermore, by employing normalized Laplacian analysis, we identify distinct cluster characteristics that could not be inferred by directly examining the collected data.
Ankle-foot orthotic management in neuromuscular disorders: recommendations for future research

Purpose: To describe research evidence supporting clinical recommendations for ankle-foot orthotic (AFO) prescription and examine common limitations in current research among individuals with stroke and cerebral palsy. Method: Three databases and one journal website were searched for articles reporting AFO interventions on gait and functional mobility outcome measures in participants with stroke or cerebral palsy. The International Society for Prosthetics and Orthotics (ISPO) best practice recommendations from consensus conferences were reviewed. Data extracted from the articles include participant characteristics, AFO intervention details, evaluation methods, and outcome measures. Results: Sixty articles were included; twenty-seven on stroke and thirty-three on cerebral palsy participants. Many articles reported insufficient detail on severity of lower limb impairment. Type of interventions included nineteen nonarticulating AFO studies, twelve articulating AFO studies and twenty-three studies testing both. Confounding factors, such as compliance, activity level and footwear, need to be considered in longitudinal studies. Conclusions: Most studies demonstrated improvement in walking speed and ankle dorsiflexion, whereas the indirect effect on knee stability remains unclear. Future research needs to provide detailed information on type and severity of lower limb impairment of participants and design features of the AFO intervention. Implications for Rehabilitation Research reports need to provide clinical measures of impairment and function to facilitate understanding the AFO’s mechanical effect during gait. Standardized outcome measures related to the prescription goals and patient’s functional mobility is essential to determine whehter the orthotic effect is beneficial. ISPO recommendations should be consulted for reporting orthotic design characteristics.
Encouraging practitioners in infection prevention and control to publish: a cross-sectional survey

Aim: The aim of this cross-sectional survey was to determine the views of infection prevention and control practitioners (IPCPs) on publishing research. Methods: A convenience sample was obtained by approaching delegates at the 2015 Infection Prevention Society conference and data were captured via a hand-held electronic device. Findings: Of the 79 respondents, most (83%) read the Journal of Infection Prevention (JIP) and found it useful for informing their practice (72%). However, most (91%) had never published in JIP, and less than half (40%) published elsewhere. The main barrier to publication was not having work suitable for publication (38%). Support (37%), training in writing for publication (10%) and time (9%) were considered to be important facilitators in encouraging respondents to publish. Discussion: Strategies that support IPCPs in developing their writing skills may encourage more IPCPs to disseminate evidence to support best practice by publishing their work in peer-reviewed journals.
Expertise Affects Inter-Observer Agreement at Peripheral Locations within a Brain Tumor

Magnetic resonance imaging (MRI) is a crucial tool for clinical brain tumor detection and delineation. Since the process of gross tumor volume delineation resides with clinicians, a better understanding of how they perform this task is required if improvements in life expectancy are to be made. Novice-expert comparison studies have been used to examine the effect of expertise on abnormality detection, but little research has investigated expertise-related differences in brain tumor delineation. In this study, undergraduate students (novices) and radiologists (experts) inspected a combination of T1 and T2 single and whole brain MRI scans, each containing a tumor. Using a tablet and stylus to provide an interactive environment, participants had an unlimited amount of time to scroll freely through the MRI slices and were instructed to delineate (i.e., draw a boundary) around any tumorous tissue. There was no reliable evidence for a difference in the gross tumor volume or total number of slices delineated between experts and novices. Agreement was low across both expertise groups and significantly lower at peripheral locations within a tumor than central locations. There was an interaction between expertise level and location within a tumor with experts displaying higher agreement at the peripheral slices than novices. An effect of brain image set on the order in which participants inspected the slices was also observed. The implications of these results for the training undertaken by early career radiologists and current practices in hospitals are discussed.
A logical framework for reasoning about access control models

The increased availability of tools and technologies to access and use the data has made more urgent the needs for data protection. Moreover, emerging applications and data models call for more flexible and expressive access control models. This has lead to an extensive research activity that has resulted in the definition of a variety of access control models, that greatly differ with respect to the access control policies they can support. The need thus arises of developing some sort of tools that make it possible to reason about the expressive power of such models and to make a comparison among the various proposals. In this paper we make a first step in this direction by proposing a formal framework for reasoning about access control models. The framework we propose is based on a logical formalism and is general enough to model both discretionary and mandatory access control policies. Each instance of the proposed framework corresponds to a C-Datalog program [8], interpreted according to a stable model semantics. In the paper, besides giving the syntax and the formal semantic of our framework, we show some examples of its application.
Noninvasive Quantitative Tomography of the Therapeutic Response to Dexamethasone in Ovalbumin-Induced Murine Asthma

Animal models of pulmonary inflammation are critical for understanding the pathophysiology of asthma and for developing new therapies. Current conventional assessments in mouse models of asthma and chronic obstructive pulmonary disease rely on invasive measures of pulmonary function and terminal characterization of cells infiltrating into the lung. The ability to noninvasively visualize and quantify the underlying biological processes in mouse pulmonary models in vivo would provide a significant advance in characterizing disease processes and the effects of therapeutics. We report the utility of near-infrared imaging agents, in combination with fluorescence molecular tomography (FMT) imaging, for the noninvasive quantitative imaging of mouse lung inflammation in an ovalbumin (OVA)-induced chronic asthma model. BALB/c mice were intraperitoneally sensitized with OVA-Alum (aluminum hydroxide) at days 0 and 14, followed by daily intranasal challenge with OVA in phosphate-buffered saline from days 21 to 24. Dexamethasone and control therapies were given intraperitoneally 4 h before each intranasal inhalation of OVA from days 21 to 24. Twenty-four hours before imaging, the mice were injected intravenously with 5 nmol of the cathepsin-activatable fluorescent agent, ProSense 680. Quantification by FMT revealed in vivo cysteine protease activity within the lung associated with the inflammatory eosinophilia, which decreased in response to dexamethasone treatment. Results were correlated with in vitro laboratory tests (bronchoalveolar lavage cell analysis and immunohistochemistry) and revealed good correlation between these measures and quantification of ProSense 680 activation. We have demonstrated the ability of FMT to noninvasively visualize and quantify inflammation in the lung and monitor therapeutic efficacy in vivo.
Interaction of Urban Heating and Local Winds During the Calm Intermonsoon Seasons in the Tropics

Rapid urbanization of cities has greatly modified the thermal and dynamic profile in the urban boundary layer. This paper attempts to study the interaction of urban heating and the local topographic‐induced flow circulation for a tropical coastal city, Greater Kuala Lumpur, in Malaysia. The role of sea‐and‐valley‐breeze‐orientated synoptic flow (SBOS) on the interaction is determined by comparing two intermonsoon periods. A state‐of‐the‐art numerical model, Advanced Research Weather Research and Forecasting model, is used to identify the influence of urbanization through modification of urban surfaces. The model reasonably reproduces the vertical sounding data and near‐surface weather parameters. The diurnal urban heating pattern is attributed to three predominant factors: (i) weak under calm and clear‐sky condition (morning heating), (ii) weak under larger atmospheric moisture content (late afternoon convection), and (iii) largest (1.4°C) due to differential cooling rate of urban and rural surface at night. The interaction of urban thermals and upper level SBOS affects the effect of urbanization on local circulation during the day. The urban thermals reduce the weak opposing SBOS (<2 m s−1) and enhance the inflow of moisture‐rich sea breeze passage. This increases the intensity of downwind convective precipitation during late afternoon. On contrary, the strong opposing SBOS (>2 m s−1) suppresses the vertical lifting of urban thermals and decelerates the sea breeze front. It is discovered that the interaction of urban heating and topographic‐induced flow is interdependent while the synoptic flow plays a critical role in modifying both factors, respectively.
Snodar: a new instrument to measure the height of the boundary layer on the Antarctic plateau

The height of the atmospheric boundary layer on the Antarctic plateau is of particular importance to designers of optical telescopes for Antarctica. Snodar was developed at the University of New South Wales to measure the height of the atmospheric boundary layer at Dome A and Dome C on the Antarctic plateau. Snodar, or Surface layer Non-Doppler Acoustic Radar, is a true monostatic high-frequency acoustic radar (SODAR) operating between 5 kHz and 15 kHz. As the height of the boundary layer at Dome C is expected to be less then 30 m, and unknown at Dome A, Snodar was designed to have a minimum sampling height of 5 m with a vertical resolution of 1 m or better. Snodar uses a PC/104 computer to perform signal processing in real time, and a USB sound card for low-latency analog IO. Snodar was designed to run autonomously storing data on USB flash disks for retrieval the following summer, while uploading of data acquisition scripts and spot checking of data is possible via Iridium satellite through UNSW's PLATO facility. Snodar also incorporates a unique in-situ calibration sphere. We present details of the design and results from testing of Snodar.
Hybrid simulation of a dual-arm space robot colliding with a floating object

In order to verify orbital operations of a dual-arm space robot on the ground, a hybrid simulator (hardware in the loop simulator) is developed. The hybrid simulator includes a 14-degrees-of-freedom (14-DOF) dual-arm robot and 9-DOF motion table. A hybrid simulator has a great advantage in simulating complicated collision with multiple contacts, because it is difficult for a numerical simulation to get reliable and accurate results of such complicated phenomena. In this paper, the system architecture and the motion planning for three motion tables are presented. Two experiments are performed to confirm the basic motion and simulate a free-flying dual- arm space robot colliding with a floating object. The feasibility of robot operation is discussed from showing the position and force data obtained in the motion simulation.
COMPOST BEDDED PACK DAIRY HOUSING: ANIMAL PERFORMANCE AND WELL-BEING AND ECONOMIC VIABILITY IN A PASTURE-BASED SYSTEM

OF DISSERTATION COMPOST BEDDED PACK DAIRY HOUSING: ANIMAL PERFORMANCE AND WELL-BEING AND ECONOMIC VIABILITY IN A PASTURE-BASED SYSTEM Improving housing for dairy cattle is of interest because hoof and udder health, which are associated with the housing environment, are important economic and welfare issues. The objectives were: 1) to assess the influence of housing––conventional cubicle (CCD) vs compost bedded pack (CBP),––and management (grazing vs semi-grazing) on the performance and welfare in dairy cows 2) describe the performance of the CBP under a grazing or semi-grazing system, and 3) to assess viability of CBP housing in a pasture-based system. This study mixes three research approaches, an analysis of existing and secondary data; an experiment, and a case-study. If taken out of context and used in isolation, this mix of methods would lead to ambiguity and confusion. But in the context of the Malawi dairy industry, it is by mixing these methods that we can best inform farmer’s decisions about the type of structures that best serve them individually and the Malawian dairy industry as a whole. Cows were evaluated weekly for udder, hock, and hoof health, under a grazing (cows kept at pasture for 33 to 42% of the day) and semi-grazing system (cows kept at pasture for 16.67% of the day). No difference was observed between grazing and semi-grazing system regarding milk yield, hoof, hock, and udder health. Sub-clinical high SCC prevalence and SCC were 22% and 48% lower in the CBP barn than in the CCD barn. Cows in the CBP produced 1.2 kg per cow/day more milk than cows in CCD. No difference in CBP performance was observed under a grazing or semi-grazing system. Partial budget analysis showed that CBP was viable with net returns of $881. The benefits of the CBP over CCD are $ 1425 per year, but it would take an investment of $5368. The farmer would be expected to pay back the investment in 3.77 years.
Proud to Belong or Proudly Different? Lay Theories Determine Contrasting Effects of Incidental Pride on Uniqueness Seeking

This research examines how incidental pride may increase consumers' tendency to seek uniqueness, depending on how they attribute the pride-inducing experience. Specifically, people who attribute their felt pride to personal traits (i.e., hubristic pride) are more likely to prefer unique options in unrelated situations, compared to tho'se who attribute pride to effort (i.e., authentic pride). This effect is driven by a heightened need for uniqueness (studies 1-3). Importantly, consumers' lay theories of achievement determine these contrasting attributions: consumers who hold an entity (vs. incremental) theory tend to attribute their felt pride to their traits (vs. efforts), and this motivates them to seek uniqueness (studies 4-5). Consumers who feel proud due to effort, but believe the effort was special to themselves, seek similarly high levels of uniqueness as those who attribute pride to their traits--which demonstrates further evidence for our proposed process (study 6). Implications and possible extensions are discussed.
Detection of User Demographics on Social Media: A Review of Methods and Recommendations for Best Practices

Researchers in fields such as sociology, demography and public health, have used data from social media to explore a diversity of questions. In public health, researchers use data from social media to monitor disease spread, assess population attitudes toward health-related issues, and to better understand the relationship between behavioral changes and population health. However, a major limitation of the use of these data for population health research is a lack of key demographic indicators such as, age, race and gender. Several studies have proposed methods for automated detection of social media users' demographic characteristics. These range from facial recognition to classic supervised and unsupervised machine learning methods. We seek to provide a review of existing approaches to automated detection of demographic characteristics of social media users. We also address the applicability of these methods to public health research; focusing on the challenge of working with highly dynamical, large scale data to study health trends. Furthermore, we provide an overview of work that emphasizes scalability and efficiency in data acquisition and processing, and make best practice recommendations.