Miracle-dz/UniFAR-FTUs huggingface dataset:
Colorizing tags in tag cloud: a novel query-by-tag music search system

This paper presents a novel content-based query-by-tag music search system for an untagged music database. We design a new tag query interface that allows users to input multiple tags with multiple levels of preference (denoted as an MTML query) by colorizing desired tags in a web-based tag cloud interface. When a user clicks and holds the left mouse button (or presses and holds his/her finger on a touch screen) on a desired tag, the color of the tag will change cyclically according to a color map (from dark blue to bright red), which represents the level of preference (from 0 to 1). In this way, the user can easily organize and check the query of multiple tags with multiple levels of preference through the colored tags. To effect the MTML content-based music retrieval, we introduce a probabilistic fusion model (denoted as GMFM), which consists of two mixture models, namely a Gaussian mixture model and a multinomial mixture model. GMFM can jointly model the auditory features and tag labels of a song. Two indexing methods and their corresponding matching methods, namely pseudo song-based matching and tag affinity-based matching, are incorporated into the pre-learned GMFM. We evaluate the proposed system on the MajorMiner and CAL-500 datasets. The experimental results demonstrate the effectiveness of GMFM and the potential of using MTML queries to search music from an untagged music database.
Atypical Squamous Cells of Undetermined Significance in Women Over 55

OBJECTIVE To determine the significance of atypical squamous cells of undetermined significance (ASCUS) in patients 55 years or older. STUDY DESIGN From January 1994, to January 1997, 8,175 cervicovaginal smears were obtained from patients 55 years or older (mean age, 64.8; range, 56-84) at University Hospitals of Cleveland. Ninety-six of these patients were diagnosed with ASCUS only or ASCUS with a qualifying statement on the smear. Patient records, follow-up cervicovaginal smears and biopsies were reviewed for a period of one to four years following the diagnosis of ASCUS. RESULTS The incidence of ASCUS only or ASCUS with a qualifying statement for patients 55 years or older was 1.8%. The ASCUS:SIL ratio was 2.6:1. An estrogen stimulation test was recommended in two cases. Women older than 55 with ASCUS were three times more likely to be receiving hormonal replacement therapy than similar-aged women with normal cervicovaginal smears. Follow-up cervicovaginal smears or biopsies were obtained on 93 (80 cervicovaginal smears, 13 biopsies). The results were the following: LSIL (13), squamous carcinoma in situ (1) and ASCUS (53); the remainder of the cases were normal. In the patients who received a second diagnosis of ASCUS, follow-up cervi covaginal smears or biopsies revealed low grade dysplasia in six. CONCLUSION Although the incidence of ASCUS and the frequency of underlying dysplasia is lower in postmenopausal women than the general population, there is still a real risk that a postmenopausal woman with ASCUS has underlying intraepithelial neoplasia. Therefore, these patients should be managed as is the general population.
Privacy preserving clustering with constraints

The $k$-center problem is a classical combinatorial optimization problem which asks to find $k$ centers such that the maximum distance of any input point in a set $P$ to its assigned center is minimized. The problem allows for elegant $2$-approximations. However, the situation becomes significantly more difficult when constraints are added to the problem. We raise the question whether general methods can be derived to turn an approximation algorithm for a clustering problem with some constraints into an approximation algorithm that respects one constraint more. Our constraint of choice is privacy: Here, we are asked to only open a center when at least $\ell$ clients will be assigned to it. We show how to combine privacy with several other constraints.
Inverse Modulation of Neuronal Kv12.1 and Kv11.1 Channels by 4-Aminopyridine and NS1643

The three members of the ether-à-go-go-gene-like (Elk; Kv12.1-Kv12.3) family of voltage-gated K+ channels are predominantly expressed in neurons, but only little information is available on their physiological relevance. It was shown that Kv12.2 channels modulate excitability of hippocampal neurons, but no native current could be attributed to Kv12.1 and Kv12.3 subunits yet. This may appear somewhat surprising, given high expression of their mRNA transcripts in several brain areas. Native Kv12 currents may have been overlooked so far due to limited knowledge on their biophysical properties and lack of specific pharmacology. Except for Kv12.2, appropriate genetically modified mouse models have not been described; therefore, identification of Kv12-mediated currents in native cell types must rely on characterization of unique properties of the channels. We focused on recombinant human Kv12.1 to identify distinct properties of these channels. We found that Kv12.1 channels exhibited significant mode shift of activation, i.e., stabilization of the voltage sensor domain in a “relaxed” open state after prolonged channel activation. This mode shift manifested by a slowing of deactivation and, most prominently, a significant shift of voltage dependence to hyperpolarized potentials. In contrast to related Kv11.1, mode shift was not sensitive to extracellular Na+, which allowed for discrimination between these isoforms. Sensitivity of Kv12.1 and Kv11.1 to the broad-spectrum K+ antagonist 4-aminopyridine was similar. However, 4-AP strongly activated Kv12.1 channels, but it was an inhibitor of Kv11 channels. Interestingly, the agonist of Kv11 channels NS1643 also differentially modulated the activity of these channels, i.e., NS1643 activated Kv11.1, but strongly inhibited Kv12.1 channels. Thus, these closely related channels are distinguished by inverse pharmacological profiles. In summary, we identified unique biophysical and pharmacological properties of Kv12.1 channels and established straightforward experimental protocols to characterize Kv12.1-mediated currents. Identification of currents in native cell types with mode shift that are activated through 4-AP and inhibited by NS1643 can provide strong evidence for contribution of Kv12.1 to whole cell currents.
Neural signatures of trust in reciprocity: A coordinate‐based meta‐analysis

Trust in reciprocity (TR) is defined as the risky decision to invest valued resources in another party with the hope of mutual benefit. Several fMRI studies have investigated the neural correlates of TR in one‐shot and multiround versions of the investment game (IG). However, an overall characterization of the underlying neural networks remains elusive. Here, a coordinate‐based meta‐analysis was employed (activation likelihood estimation method, 30 articles) to investigate consistent brain activations in each of the IG stages (i.e., the trust, reciprocity and feedback stage). Results showed consistent activations in the anterior insula (AI) during trust decisions in the one‐shot IG and decisions to reciprocate in the multiround IG, likely related to representations of aversive feelings. Moreover, decisions to reciprocate also consistently engaged the intraparietal sulcus, probably involved in evaluations of the reciprocity options. On the contrary, trust decisions in the multiround IG consistently activated the ventral striatum, likely associated with reward prediction error signals. Finally, the dorsal striatum was found consistently recruited during the feedback stage of the multiround IG, likely related to reinforcement learning. In conclusion, our results indicate different neural networks underlying trust, reciprocity, and feedback learning. These findings suggest that although decisions to trust and reciprocate may elicit aversive feelings likely evoked by the uncertainty about the decision outcomes and the pressing requirements of social standards, multiple interactions allow people to build interpersonal trust for cooperation via a learning mechanism by which they arguably learn to distinguish trustworthy from untrustworthy partners. Hum Brain Mapp 38:1233–1248, 2017. © 2016 Wiley Periodicals, Inc.
Burden of disease, research funding and innovation in the UK: Do new health technologies reflect research inputs and need?

Objectives New and emerging health technologies (innovation outputs) do not always reflect conditions representing the greatest disease burden. We examine the role of research and development (R&D) funding in this relationship, considering whether areas with fewer innovative outputs receive an appropriate share of funding relative to their disease burden. Methods We report a retrospective observational study, comparing burden of disease with R&D funding and innovation output. UK disability-adjusted life years (DALYs) and deaths came from the World Health Organization (WHO) 2004 Global Burden of Disease estimates; funding estimates from the UK Clinical Research Collaboration’s 2006 Health Research Analysis; and innovation output was estimated by the number of new and emerging technologies reported by the National Institute for Health Research (NIHR) Horizon Scanning Centre between 2000 and 2009. Results Disease areas representing the biggest burden were generally associated with the most funding and innovation output; cancer, neuropsychiatric conditions and cardiovascular disease together comprised approximately two-thirds of DALYs, funding and reported technologies. Compared with DALYs, funding and technologies were disproportionately high for cancer, and technologies alone were disproportionately high for musculoskeletal conditions and endocrine/metabolic diseases. Neuropsychiatric conditions had comparatively few technologies compared to both DALYs and funding. The relationship between DALYs and innovation output appeared to be mediated by R&D funding. Conclusions The relationship between burden of disease and new and emerging health technologies for different disease areas is partly dependent on the associated level of R&D funding (input). Discrepancies among key groups may reflect differential focus of research funding across disease areas.
HIV-1 (p24)–Positive Multinucleated Giant Cells in HIV-Associated Lymphoepithelial Lesion of the Parotid Gland

BACKGROUND Cystic benign lymphoepithelial lesion (CBLL) is a well-recognized parotid disorder the diagnosis of which can be made on the basis of clinical findings, human immunodeficiency virus (HIV) testing, image studies and fine needle aspiration (FNA). Most aspirations are cystic, and the lesion can be recognized if the triad of foamy macrophages, lymphoid and epithelial (squamous) cells is observed. CASES The authors recently observed FNA cytologic features of two HIV-associated cases that exhibited numerous multinucleated giant cells (MGCs) but failed to show the epithelial component. A subsequent surgical resection was performed in one patient. Similarly to what has been described for nasopharyngeal (adenoid and tonsil) lymphoid tissue of HIV-positive patients, intense immunoexpression of S-100 and p24 (HIV-1) protein was present in MGC. CONCLUSION The diagnosis of HIV-associated CBLL should always be considered if a parotid cystic lesion presents with numerous MGCs. Immunocytochemical detection of p24 (HIV-1) protein in MGC becomes a very useful diagnostic aid and extends to parotid CBLL many of those pathogenic features of HIV-1 infection already noted in other HIV-1-infected, lymphoid oropharyngeal lesions.
Relationship between structural and functional connectivity change across the adult lifespan: A longitudinal investigation

Extensive efforts are devoted to understand the functional (FC) and structural connections (SC) of the brain. FC is usually measured by functional magnetic resonance imaging (fMRI), and conceptualized as degree of synchronicity in brain activity between different regions. SC is typically indexed by measures of white matter (WM) properties, for example, by diffusion weighted imaging (DWI). FC and SC are intrinsically related, in that coordination of activity across regions ultimately depends on fast and efficient transfer of information made possible by structural connections. Convergence between FC and SC has been shown for specific networks, especially the default mode network (DMN). However, it is not known to what degree FC is constrained by major WM tracts and whether FC and SC change together over time. Here, 120 participants (20–85 years) were tested at two time points, separated by 3.3 years. Resting‐state fMRI was used to measure FC, and DWI to measure WM microstructure as an index of SC. TRACULA, part of FreeSurfer, was used for automated tractography of 18 major WM tracts. Cortical regions with tight structural couplings defined by tractography were only weakly related at the functional level. Certain regions of the DMN showed a modest relationship between change in FC and SC, but for the most part, the two measures changed independently. The main conclusions are that anatomical alignment of SC and FC seems restricted to specific networks and tracts, and that changes in SC and FC are not necessarily strongly correlated. Hum Brain Mapp 38:561–573, 2017. © 2016 Wiley Periodicals, Inc.
White matter change with apathy and impulsivity in frontotemporal lobar degeneration syndromes

Objective To identify the white matter correlates of apathy and impulsivity in the major syndromes associated with frontotemporal lobar degeneration, using diffusion-weighted imaging and data from the PiPPIN (Pick's Disease and Progressive Supranuclear Palsy: Prevalence and Incidence) study. We included behavioral and language variants of frontotemporal dementia, corticobasal syndrome, and progressive supranuclear palsy. Methods Seventy patients and 30 controls underwent diffusion tensor imaging at 3-tesla after detailed assessment of apathy and impulsivity. We used tract-based spatial statistics of fractional anisotropy and mean diffusivity, correlating with 8 orthogonal dimensions of apathy and impulsivity derived from a principal component analysis of neuropsychological, behavioral, and questionnaire measures. Results Three components were associated with significant white matter tract abnormalities. Carer-rated change in everyday skills, self-care, and motivation correlated with widespread changes in dorsal frontoparietal and corticospinal tracts, while carer observations of impulsive–apathetic and challenging behaviors revealed disruption in ventral frontotemporal tracts. Objective neuropsychological tests of cognitive control, reflection impulsivity, and reward responsiveness were associated with focal changes in the right frontal lobe and presupplementary motor area. These changes were observed across clinical diagnostic groups, and were not restricted to the disorders for which diagnostic criteria include apathy and impulsivity. Conclusion The current study provides evidence of distinct structural network changes in white matter associated with different neurobehavioral components of apathy and impulsivity across the diverse spectrum of syndromes and pathologies associated with frontotemporal lobar degeneration.
Cytologic Grading of Invasive Breast Carcinoma

OBJECTIVE To estimate cytologic grade and correlate it with the other known prognostic factors, such as tumor differentiation, growth fraction, estrogen receptor status and nodal status. STUDY DESIGN Fine needle aspirates from 104 invasive ductal carcinomas were stained by the Papanicolaou method and examined for necrosis, cellular size, nuclear/cytoplasmic ratio, nuclear pleomorphism, nucleoli, chromatin granularity and density of chromatin. We established a semiquantitative scoring system based on the above features and correlated cytologic findings with clinicopathologic variables. RESULTS Histologic grade correlated positively with cytologic grade and negatively with estrogen receptor positivity. Moreover, high cytologic grade was associated with nodal metastasis and proliferative index labeling by MIB-1. CONCLUSION This study showed that our grading system for breast cancer on fine needle aspiration cytology is feasible on a routine diagnostic basis. Cytologic grading can provide more information than usual on tumor biologic behavior.
Daily HRI evaluation at a classroom environment: reports from dance interaction experiments

The design and development of social robots that interact and assist people in daily life requires moving into unconstrained daily-life environments. This presents unexplored methodological challenges to robotic researchers. Is it possible, for example, to perform useful experiments in the uncontrolled conditions of everyday life environments? How long do these studies need to be to provide reliable results? What evaluations methods can be used? In this paper we present preliminary results on a study designed to evaluate an algorithm for social robots in relatively uncontrolled, daily life conditions. The study was conducted as part of the RUBI project, whose goal is to design and develop social robots by immersion in the environment in which the robots are supposed to operate. First we found that in spite of the relative chaotic conditions and lack of control existing in the daily activities of a child-care center, it is possible to perform experiments in a relatively short period of time and with reliable results. We found that continuous audience response methods borrowed from marketing research provided good inter-observer reliabilities, in the order of 70%, and temporal resolution (the cut-off frequency is in the order of 1 cycle per minute) at low cost (evaluation is performed continuously in real time). We also experimented with objective behavioral descriptions, like tracking children's movement across a room. These approaches complemented each other and provided a useful picture of the temporal dynamics of the child-robot interaction, allowing us to gather baseline data for evaluating future systems. Finally, we also touch the ongoing study of behavior analysis through 3 months long-term child-robot interaction.
Surface Phase Transformation During Grinding of Y-TZP

Phase transformation by grinding has been studied in heat-treated 2.5% molar Y-TZP with a duplex tetragonal–cubic microstructure developed by exposure at 1650°C for different times as well as in specimens with a large amount of monoclinic phase induced by prior aging at 300°C in air. For the grinding process used, it is shown that no monoclinic phase is detected in high transformable microstructures with a relatively large tetragonal grain size. Additional experiments are discussed in which it is shown that, by grinding previously aged specimens with large fractions of monoclinic phase, the amount of this phase is strongly reduced after grinding.
Analysis of FRP-Strengthened RC Beam-Column Joints

Analytical models are presented in this study for the analysis of reinforced concrete joints strengthened with composite materials in the form of externally bonded reinforcement comprising unidirectional strips or flexible fabrics. The models provide equations for stresses and strains at various stages of the response (before or after yielding of the beam or column reinforcement) until the ultimate capacity is reached, defined by concrete crushing or fiber-reinforced polymer (FRP) failure due to fracture or debonding. Solutions to these equations are obtained numerically. The models provide useful information on the shear capacity of FRP-strengthened joints in terms of the quantity and configuration of the externally bonded reinforcement and may be used to design FRP patching for inadequately detailed beam-column joints. A number of case studies are examined in this article, indicating that even low quantities of FRP materials may provide significant enhancement of the shear capacity. The effectiveness of external reinforcement increases considerably if debonding is suppressed and depends heavily on the distribution of layers in the beam and column. The latter depends on the relative quantities of steel reinforcement crossing the joint panel and the level of axial load in the column. Analytical shear strength predictions were in good agreement with test results found in the literature, thus adding confidence to the validity of the proposed models.
Depression in Family Caregivers of Mexican Descent: Exacerbated by Stress and Mitigated by Mutuality.

Despite common assumptions that non-paid family caregivers of Mexican descent benefit spiritually from their roles according to cultural familistic norms, there is also evidence of caregiver stress resulting in depression. Depression has the potential to seriously affect caregivers' health and their ability to continue to provide care. The current study's purpose was to examine the relationships among depression, stress, and mutuality (i.e., the quality of the caregiver-care recipient relationship) (N = 74 caregivers of Mexican descent in the southwestern United States). Multiple regression models and exploratory mediational analyses indicated that the stress-depression relationship can be significantly mediated by mutuality. Results support culturally appropriate interventions to decrease caregiver stress and depression by promoting mutuality. In addition, with changing trends in outside work roles and mobility of caregivers of Mexican descent, policy should make services truly accessible to support caregiving families of Mexican descent. [Res Gerontol Nurs. 2017; 10(3):106-113. ].
The Role of Bacillithiol in Gram-Positive Firmicutes

Abstract Significance: Since the discovery and structural characterization of bacillithiol (BSH), the biochemical functions of BSH-biosynthesis enzymes (BshA/B/C) and BSH-dependent detoxification enzymes (FosB, Bst, GlxA/B) have been explored in Bacillus and Staphylococcus species. It was shown that BSH plays an important role in detoxification of reactive oxygen and electrophilic species, alkylating agents, toxins, and antibiotics. Recent Advances: More recently, new functions of BSH were discovered in metal homeostasis (Zn buffering, Fe-sulfur cluster, and copper homeostasis) and virulence control in Staphylococcus aureus. Unexpectedly, strains of the S. aureus NCTC8325 lineage were identified as natural BSH-deficient mutants. Modern mass spectrometry-based approaches have revealed the global reach of protein S-bacillithiolation in Firmicutes as an important regulatory redox modification under hypochlorite stress. S-bacillithiolation of OhrR, MetE, and glyceraldehyde-3-phosphate dehydrogenase (Gap) functions, analogous to S-glutathionylation, as both a redox-regulatory device and in thiol protection under oxidative stress. Critical Issues: Although the functions of the bacilliredoxin (Brx) pathways in the reversal of S-bacillithiolations have been recently addressed, significantly more work is needed to establish the complete Brx reduction pathway, including the major enzyme(s), for reduction of oxidized BSH (BSSB) and the targets of Brx action in vivo. Future Directions: Despite the large number of identified S-bacillithiolated proteins, the physiological relevance of this redox modification was shown for only selected targets and should be a subject of future studies. In addition, many more BSH-dependent detoxification enzymes are evident from previous studies, although their roles and biochemical mechanisms require further study. This review of BSH research also pin-points these missing gaps for future research. Antioxid. Redox Signal. 28, 445–462.