Miracle-dz/UniFAR-FTUs huggingface dataset:
Identifying user-based criteria for Web pages

Reports on Phase I of a two‐part project to identify and implement user‐based design criteria in World Wide Web pages. The purpose of the identification phase (Phase I) is to identify the criteria that influence a particular user community’s use of the Web and to analyze these within the context of the users’ overall information‐gathering behavior. Data were gathered through a questionnaire and electronic focus group session with nine faculty from four business schools. Participants identified 49 Web page features which clustered into eight broad categories of criteria having a significant positive or negative impact on their use of WWW pages. They also identified types of information normally used in work activities; methods of finding this information within the current information service environment; likely changes in behavior if the information became available via the Web, including willingness to pay.
Anaerobic degradation of alkylated benzenes in denitrifying laboratory aquifer columns

Toluene and m-xylene were rapidly mineralized in an anaerobic laboratory aquifer column operated under continuous-flow conditions with nitrate as an electron acceptor. The oxidation of toluene and m-xylene was coupled with the reduction of nitrate, and mineralization was confirmed by trapping 14CO2 evolved from 14C-ring-labeled substrates. Substrate degradation also took place when nitrous oxide replaced nitrate as an electron acceptor, but decomposition was inhibited in the presence of molecular oxygen or after the substitution of nitrate by nitrite. The m-xylene-adapted microorganisms in the aquifer column degraded toluene, benzaldehyde, benzoate, m-toluylaldehyde, m-toluate, m-cresol, p-cresol, and p-hydroxybenzoate but were unable to metabolize benzene, naphthalene, methylcyclohexane, and 1,3-dimethylcyclohexane. Isotope-dilution experiments suggested benzoate as an intermediate formed during anaerobic toluene metabolism. The finding that the highly water-soluble nitrous oxide served as electron acceptor for the anaerobic mineralization of some aromatic hydrocarbons may offer attractive options for the in situ restoration of polluted aquifers.
Abnormal neural response to feedback on planning and guessing tasks in patients with unipolar depression

Background. It has been suggested that patients with unipolar depression show abnormal responses to negative feedback in the performance of cognitive tasks. Positron emission tomography (PET) has previously identified blood flow abnormalities in depressed patients during cognitive performance. We have also used PET to identify regions where there is differential neural response to performance feedback in normal volunteers. In this study we aimed to test the hypothesis that blood flow in these regions, the medial caudate and ventromedial prefrontal cortex, would be abnormal in depressed patients. Methods. Six patients with unipolar depression and six matched controls were scanned using PET while performing cognitive tasks in the presence and absence of feedback. Results. Compared with controls, depressed patients failed to show significant activation in the medial caudate and ventromedial orbitofrontal cortex. Blood flow was lower and a differential response, observed in normals, under different task and feedback conditions was not seen in the patients. Discussion. The findings suggest that the behavioural response to feedback in depressed patients is associated with an abnormal neural response within the medial caudate and ventromedial orbitofrontal cortex, regions implicated in reward mechanisms. We argue that the observed abnormalities may depend on a combination of psychological factors, with both cognitive and emotive components.
Use and impact of usual intake models on dietary exposure estimate and risk assessment of chemical substances: a practical example for cadmium, acrylamide and sulphites

To estimate of food and nutrient intakes, 24-h recalls are frequently used in dietary assessment. However intake data collected for a short period are a limited estimator of long-term usual intake. An important limitation of such data is that the within-person variability tends to inflate the intake distribution leading to a biased estimation of extreme percentiles. Statistical models, named usual-intake models, that separate the within-person variability from the between-persons variability, have lately been implemented. The main objectives of this study were to highlight the potential impact that usual-intake models can have on exposure estimate and risk assessment and to point out which are the key aspects to be considered in order to run these models properly and be sure to interpret the output correctly. To achieve the goal we used the consumption data obtained by the French dietary survey INCA2 and the concentration data collected during the French TDS2, using Monte Carlo Risk Assessment (MCRA) software, release 8.0. For the three substances included in this study (cadmium, acrylamide and sulphites), the exposure of the upper percentiles was significantly reduced when using usual-intake models in comparison with the results obtained in the observed individual mean models, even if in terms of risk assessment the impact of using usual-intake models was limited. From the results it appears that the key aspects to consider when using usual-intake models are: (1) the normality of the log-transformed intake distribution, (2) the contribution per single food group to the total exposure, and (3) the independency of food consumption data on multiple days. In conclusion, usual-intake models may have an impact on exposure estimates although, referring to the results, it did not bring any changes in terms of risk assessment, but further investigations are needed.
Monkeying around with ploidy

Inferences of whole genome duplication (WGD) events accompany the annotation of every newly sequenced plant genome, but much remains unknown about the evolutionary processes and pathways relating to WGD (Soltis et al. 2010). What ecological, biogeographical and genetic factors cause WGD to occur in nature? How does WGD affect gene expression? How do genomes evolve after WGD? New species that have arisen recently through WGD are good places to seek answers to such questions. These could be relatively common in nature, but reliably demonstrating their recent origin requires documentary evidence, which can be very hard to come by. Thus far, records of species introductions and meticulous botanizing have demonstrated six new natural allopolyploids in just four genera: Tragopogon miscellus and T. mirus, Senecio cambrensis and S. eboracensis, Spartina anglica and Cardamine schultzii (Abbott & Rieseberg 2012; Ainouche et al. 2009; Soltis & Soltis 2009). It is risky to generalize about a universal feature of plant evolution from such a small sample; more examples are needed, in different genera. It is therefore of considerable interest that Mario Vallejo‐Marin of University of Stirling has this year named a new allopolyploid species of monkey flower, Mimulus peregrinus, and presented evidence that it is <140 years old (Vallejo‐Marin 2012). This discovery is particularly timely as the monkey flower genus is developing rapidly as a model system for ecological genetics (Wu et al. 2008), and in the current issue of Molecular Ecology, Jennifer Modliszewski and John Willis of Duke University present new data showing high genetic diversity in another recently discovered monkey flower allopolyploid, M. sookensis (Modliszewski & Willis 2012).
Discordance between Viral Loads Determined by Roche COBAS AMPLICOR Human Immunodeficiency Virus Type 1 Monitor (Version 1.5) Standard and Ultrasensitive Assays Caused by Freezing Patient Plasma in Centrifuged Becton-Dickinson Vacutainer Brand Plasma Preparation Tubes

ABSTRACT The Roche COBAS AMPLICOR human immunodeficiency virus type 1 (HIV-1) Monitor (version 1.5) standard and ultrasensitive viral load assays often gave discordant results, with viral loads from the standard assay exceeding those from the ultrasensitive assay by more than 0.5 log10 for approximately 20% of specimens received. We began studies to determine the extent, magnitude, and reproducibility of the discordance between the assays and to discover and eliminate the cause of this discordance. Until then, we revised our standard operating procedure to include both standard and ultrasensitive testing on all specimens submitted for viral load determinations. Discordant results usually recurred on retesting. They were most prevalent for specimens with ultrasensitive viral loads of <1,000 and rare for specimens with viral loads of >10,000. Often, standard assay results exceeded those of the ultrasensitive assay by 50- to 100-fold. At higher viral loads, the difference between the standard and ultrasensitive assays persisted, but the percent difference was smaller and rarely caused discordance. The proportion of discordant results was significantly higher in specimens from pediatric patients than in specimens from adults. The ultrasensitive viral load determinations generally agreed with the results of the B-DNA (Bayer) viral load assays. If the plasma was transferred from the centrifuged plasma preparation tubes before freezing, standard and ultrasensitive results were concordant with each other and with values determined on plasma from lavender-topped EDTA tubes.
Prediction of outcome following paraquat poisoning by arterial lactate concentration-time data

The present study retrospectively analyzed 170 patients diagnosed with paraquat (PQ) poisoning with the aim of clarifying whether the arterial lactate-time (arterial lactate concentration × time between ingestion and arterial lactate measurement) was a good predictor of mortality in patients with acute PQ poisoning. The results indicated that there was a positive correlation between the arterial lactate-time and PQ concentration-time (ρ=0.485). In addition, the arterial lactate-time data exhibited a similar discriminative power to the plasma PQ concentration-time data (z=0.712; P=0.864). For the receiver operating characteristic curve analysis, the lactate-time data had an area of 0.782 with a cut-off value of 11.95 mmol/l.h (sensitivity, 64.52%; specificity, 84.42%). To calculate the predicted probability of survival for any specified time and initial arterial lactate concentration, the following formula was derived based on the logistic regression coefficients: Logit(p) = 3.066 − 0.139 × (time lag following PQ ingestion) − 0.177 × (initial arterial lactate concentration); where the probability of survivors = 1/1 + e−logit(p). Therefore, the arterial lactate-time data exhibited a good predictive power for evaluating the prognosis of patients with acute PQ poisoning.
A priori error estimates for compatible spectral discretization of the Stokes problem for all admissible boundary conditions

This paper describes the recently developed mixed mimetic spectral element method for the Stokes problem in the vorticity-velocity-pressure formulation. This compatible discretization method relies on the construction of a conforming discrete Hodge decomposition, that is based on a bounded projection operator that commutes with the exterior derivative. The projection operator is the composition of a reduction and a reconstruction step. The reconstruction in terms of mimetic spectral element basis-functions are tensor-based constructions and therefore hold for curvilinear quadrilateral and hexahedral meshes. For compatible discretization methods that contain a conforming discrete Hodge decomposition, we derive optimal a priori error estimates which are valid for all admissible boundary conditions on both Cartesian and curvilinear meshes. These theoretical results are confirmed by numerical experiments. These clearly show that the mimetic spectral elements outperform the commonly used H(div)-compatible Raviart-Thomas elements.
When capacitive transduction meets the thermomechanical limit: Towards femto-newton force sensors at very high frequency

We show that the capacitive transduction of a MEMS device using a setup based on a microwave detection scheme achieves the measurement of the thermomechanical noise spectrum of a high-frequency (>10 MHz) high-stiffness (>105 N/m) resonator, reaching the outstanding displacement resolution of 1 fm/√Hz. This result paves the way for vibrating sensors with exquisite force resolution in the fN/vHz range, enabling large-bandwidth measurements of mechanical interactions at small scale and rheology of fluids at very high frequency. An example of application is given and concerns atomic force microscopy images of biomolecular assemblies.
Test and Analysis of a Buckling-Critical Large-Scale Sandwich Composite Cylinder

Structural stability is an important design consideration for launch-vehicle shell structures and it is well known that the buckling response of such shell structures can be very sensitive to small geometric imperfections. As part of an effort to develop new buckling design guidelines for sandwich composite cylindrical shells, an 8-ft-diameter honeycomb-core sandwich composite cylinder was tested under pure axial compression to failure. The results from this test are compared with finite-element-analysis predictions and overall agreement was very good. In particular, the predicted buckling load was within 1% of the test and the character of the response matched well. However, it was found that the agreement could be improved by including composite material nonlinearity in the analysis, and that the predicted buckling initiation site was sensitive to the addition of small bending loads to the primary axial load in analyses.
Characterizing the Energetic Landscape in Solution Processable Solar Cells via Frequency Dependent Impedance Measurements

This thesis presents measurements and analyses aimed at describing charge transport dynamics in quantum dot (QD) photovoltaics (PVs). Due to their solution processability and unique size-dependent optoelectronic properties, ensembles of electronically coupled QDs (QD solids) provide an exciting platform for next generation PV devices. However, the structural disorder associated with the formation of conductive QD solids gives rise to a complicated density of states (DOS) emerging from the distribution of mesoscale charge dynamics occurring in these materials. I present phenomological models to describe the DOS in the disordered energetic and spatial landscape of QD solids that relies on a suite of frequency-domain measurements known as impedance spectroscopy (IS). Though specific applications of IS such as thermal admittance spectroscopy (TAS) have been applied to the capacitance characteristics of QD solids, a fuller picture of the DOS in these materials is afforded by analysis of the time-scales evident in the full impedance characteristics of QD devices. I heuristically propose extensions of charge transport models developed for capacitance-voltage (CV) measurements of bulk semiconductors to describe the frequency-dependent capacitance and conductance response of a variety of QD solar cell device architectures. In Chapter 3, I show how TAS and drive level capacitance profiling (DLCP) characterization of a QD Schottky junction is linked to charge hopping processes observed in AC conductance data. This allows me to map the time scales detected in these data to the DOS in the QD solid. I then suggest how the observed DOS translates onto macroscale device properties like the diode current. In Chapter 4, I apply these techniques to a QD heterojunction device. I use forward biased IS characterization to suggest the presence of a defect state at the junction interface, and calculate the associated distribution of carrier lifetimes. In Chapter 5, I attempt to extend this model to a QD p-i-n heterojunction solar cell, and obtain a response consistent with interfacial trapping and carrier transport. Though unambiguous identification of the origin of these responses proves beyond the scope of this thesis, I use illuminated TAS and DLCP measurements to show the presence of an interfacial trap for photogenerated electrons. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group Physics & Astronomy First Advisor Cherie R. Kagan This dissertation is available at ScholarlyCommons: https://repository.upenn. edu/edissertations/3203 Subject Categories Condensed Matter Physics | Nanoscience and Nanotechnology This dissertation is available at ScholarlyCommons: https://repository.upenn. edu/edissertations/3203 CHARACTERIZING THE ENERGETIC LANDSCAPE IN SOLUTION PROCESSABLE SOLAR CELLS VIA FREQUENCY DEPENDENT IMPEDANCE MEASUREMENTS
First and second generation antipsychotics: translating the results from pragmatic trials into clinical practice

Epidemiology and Psychiatric Sciences / Volume 22 / Issue 03 / September 2013, pp 239 240 DOI: 10.1017/S2045796012000741, Published online: 06 February 2013 Link to this article: http://journals.cambridge. org/abstract_S2045796012000741 How to cite this article: S. R. Marder (2013). First and second generation antipsychotics: translating the results from pragmatic trials into clinical practice. Epidemiology and Psychiatric Sciences, 22, pp 239-240 doi:10.1017/S2045796012000741 Request Permissions : Click here
In vitro activity of CP-65,207, a new penem antimicrobial agent, in comparison with those of other agents

CP-65,207 is a new parenteral penem antibiotic with a broad spectrum that includes gram-positive, gram-negative, and anaerobic microorganisms, with MICs for 90% (MIC90s) of the majority of 1,101 clinical pathogens tested being less than or equal to 1 microgram/ml. The compound was from 10- to 100-fold more active than cefoxitin and broad-spectrum cephalosporins against gram-positive bacteria and anaerobes. CP-65,207 was less active than imipenem for staphylococci, group A streptococci, and Enterococcus faecalis. Against members of the family Enterobacteriaceae, CP-65,207 was in general 100-fold more active than cefoxitin, 5- to 10-fold more active than broad-spectrum cephalosporins, and 2-fold more active than imipenem. Fresh clinical isolates that were resistant to broad-spectrum cephalosporins were highly susceptible to CP-65,207 and imipenem (MIC90, 1 microgram/ml). Isolates of Enterococcus faecalis, Serratia marcescens, and anaerobic Peptococcus spp. had MIC90s of 8, 2, and 3.12 micrograms/ml, respectively. CP-65,207 was not very active against methicillin-resistant staphylococci or Pseudomonas aeruginosa. Killing kinetics showed that against some strains CP-65,207 is rapidly bactericidal at concentrations well below those required to achieve a similar degree of killing with cefotaxime, ceftazidime, and ceftriaxone. CP-65,207 was only slightly susceptible to hydrolysis by type I cephalosporinases and TEM-1, SHV-1, and PSE-2 plasmid-encoded enzymes. It had the highest affinity for penicillin-binding proteins 2, 1A, 1B, and 3 in cell-free preparations of Escherichia coli W-7.
Random access for machine-to-machine communication in LTE-advanced networks: issues and approaches

Machine-to-machine communication, a promising technology for the smart city concept, enables ubiquitous connectivity between one or more autonomous devices without or with minimal human interaction. M2M communication is the key technology to support data transfer among sensors and actuators to facilitate various smart city applications (e.g., smart metering, surveillance and security, infrastructure management, city automation, and eHealth). To support massive numbers of machine type communication (MTC) devices, one of the challenging issues is to provide an efficient way for multiple access in the network and to minimize network overload. In this article, we review the M2M communication techniques in Long Term Evolution- Advanced cellular networks and outline the major research issues. Also, we review the different random access overload control mechanisms to avoid congestion caused by random channel access of MTC devices. To this end, we propose a reinforcement learning-based eNB selection algorithm that allows the MTC devices to choose the eNBs (or base stations) to transmit packets in a self-organizing fashion.
Slow cryopreservation is not superior to vitrification in human spermatozoa; an experimental controlled study

Background: Spermatozoa cryopreservation is used for the management of infertility and some other medical conditions. The routinely applied cryopreservation technique depends on permeating cryoprotectants, whose toxic effects have raised the attention towards permeating cryoprotectants-free vitrification technique. Objective: To compare between the application of slow cryopreservation and vitrification on human spermatozoa. Materials and Methods: This was an experimental controlled study involving 33 human semen samples, where each sample was divided into three equal parts; fresh control, conventional slow freezing, and permeating cryoprotectants-free vitrification. Viability and mitochondrial membrane potential (MMP) of control and post-thawing spermatozoa were assessed with the sperm viability kit and the JC-1 kit, respectively, using fluorescence-activated cell sorting analysis. Results: Significant reduction of the progressive motility, viability and MMP was observed by the procedure of freezing and thawing, while there was not any significant difference between both cryopreservation techniques. Cryopreservation resulted in 48% reduction of the percentage of viable spermatozoa and 54.5% rise in the percentage of dead spermatozoa. In addition, high MMP was reduced by 24% and low MMP was increased by 34.75% in response to freezing and thawing. Progressive motility of spermatozoa was correlated significantly positive with high MMP and significantly negative with low MMP in control as well as post-thawing specimens (r=0.8881/ -0.8412, 0.7461/ -0.7510 and 0.7603/ -0.7839 for control, slow and vitrification respectively, p=0.0001). Conclusion: Although both cryopreservation techniques have similar results, vitrification is faster, easier and associated with less toxicity and costs. Thus, vitrification is recommended for the clinical application.
Production, Manufacturing and Logistics Coordination of cooperative advertising in a two-level supply chain when manufacturer offers discount q

We studied the coordination of cooperative advertisement in a manufacturer–retailer supply chain when the manufacturer offers price deductions to customers. With a price sensitive market, the expected demand with cooperative advertising and price deduction is demonstrated. When the manufacturer is a leader, we obtained the optimal national brand name investment, local advertisement and associated manufacturers allowance with any given price deduction. When the manufacturer offers more price deduction to customers, the retailer will increase local advertisement if the manufacturer provides the same portion of the local advertising allowance. We obtained the necessary and sufficient condition for the price deduction to ensure an increase of manufacturers profit, and a search procedure for determining such an optimal price deduction is provided as well. When the manufacturer and retailer are partners, we obtained the optimal national brand name investment and local advertisement. For any given price deduction, the total profit for the supply chain with cooperative scheme is always higher than that with the non-cooperative scheme. When price elasticity of demand is larger than one, the resulting closed form optimal price deduction with partnership is also obtained. To increase profits for both parties in a supply chain, we recommend that coordination in local and national cooperative advertising with a partnership relationship between manufacturer and retailer is the best solution. The bargaining results show how to share the profit gain between the manufacturer and the retailer, and determine the associated pricing and advertising policies for both parties. 2004 Elsevier B.V. All rights reserved.