Miracle-dz/UniFAR-FTUs huggingface dataset:
What Affects the Advertising Sharing Behavior among Mobile SNS Users? The Relationships between Social Capital, Outcome Expectations and Prevention Pride

Mobile networks practice of social networking service that gives individuals an easy way to exchange messages and ideas with others base on interpersonal relationships. However, why individuals spread advertisements in their social circles through mobile applications is not well understood: is this the result of environment impact or the result of individual characteristics? To tackle this problem, we apply social capital theory to examine how social capital influence advertising recommendation quality and advertising sharing behavior in mobile networks. And, we also use social cognitive theory and regulatory focus theory to investigate the motivations behind people's advertising sharing behavioral in mobile networks. Data collected from 319 mobile social networking users provide support for the proposed model. The analysis of the sample shows that the social capital and outcome expectations are significant indicators of individual’s ad-sharing behavior in the mobile SNS environment. Moreover, the prevention pride has an obvious interaction influence on the perception and behavior of M-ad sharing. Implications for research and practice are discussed.
The Functional Differences between Pro-survival and Pro-apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (BH3) Domains*

Background: Anti- and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins possess Bcl-2 homology 3 (BH3) domains generally associated with cell death induction. Results: Features of anti-apoptotic BH3 domains were identified that limit their killing activity but are important for protein stability. Conclusion: Pro- and anti-apoptotic BH3 domains are distinct, which affects their function. Significance: Differences in BH3 domains have significant consequences in apoptotic signaling. Bcl-2 homology 3 (BH3) domains are short sequence motifs that mediate nearly all protein-protein interactions between B cell lymphoma 2 (Bcl-2) family proteins in the intrinsic apoptotic cell death pathway. These sequences are found on both pro-survival and pro-apoptotic members, although their primary function is believed to be associated with induction of cell death. Here, we identify critical features of the BH3 domains of pro-survival proteins that distinguish them functionally from their pro-apoptotic counterparts. Biochemical and x-ray crystallographic studies demonstrate that these differences reduce the capacity of most pro-survival proteins to form high affinity “BH3-in-groove” complexes that are critical for cell death induction. Switching these residues for the corresponding residues in Bcl-2 homologous antagonist/killer (Bak) increases the binding affinity of isolated BH3 domains for pro-survival proteins; however, their exchange in the context of the parental protein causes rapid proteasomal degradation due to protein destabilization. This is supported by further x-ray crystallographic studies that capture elements of this destabilization in one pro-survival protein, Bcl-w. In pro-apoptotic Bak, we demonstrate that the corresponding distinguishing residues are important for its cell-killing capacity and antagonism by pro-survival proteins.
Navigation of non-communicating autonomous mobile robots with guaranteed connectivity

SUMMARY We consider the connectivity of autonomous mobile robots. The robots navigate using simple local steering rules without requiring explicit communication among themselves. We show that using only position information of neighbors, the group connectivity can be sustained even in the case of bounded position measurement errors and the occlusion of robots by other robots in the group. In implementing the proposed scheme, sub-optimal solutions are invoked to avoid an excessive computational burden. We also discuss the possibility of deadlock which may bring the group to a standstill and show that the proposed methodology avoids such a scenario in real-life settings.
Cross-Cultural Validation of the Basic Psychological Needs in Physical Education Scale between Portugal and Brazil Samples

Abstract The main propose of this study is the cross-cultural validation of the Basic Psychological Needs in Physical Education Scale among Portugal and Brazil samples, through the study of measurement model invariance. Participated in this study, two independent samples, one with 616 Portuguese students, of the 2nd and 3rd basic grade of public school, aged between 9 and 18 years old and another with 450 Brazilian students, from 1st, 2nd and 3rd middle grade of public and private school, aged between 14 and 18 years old. The results support the suitability of the model (three factors, each one with four items), showing an adequate fit to the data in each sample (Portugal: χ2 = 203.8, p = .001, df = 51, SRMR = .062, NNFI = .926, CFI = .943, RMSEA = .070, RMSEA 90% IC = .060–.080; Brazil: χ2 = 173.7, p = .001, df = 51, SRMR = .052, NNFI = .940, CFI = .954, RMSEA = .073, RMSEA 90% IC = .061–.085), as well valid cross-cultural invariance among Portuguese e Brazilian samples (∆CFI ≤ .01). Those findings allow us to conclude that scale can be used to measure the basic psychological needs in physical education in Portugal and in Brazil.
The use of the species concept in paleontology. Comment on "Nesiotites rafelinensis sp. nov., the earliest shrew (Mammalia, Soricidae) from the Balearic Islands, Spain" by Rofes et al., 2012

The earliest representative of Nesiotites from Caló d’en Rafelino (Mallorca) has been recently described as a new species (Nesiotites rafelinensis) based on a single hemimandible with p4-m3. A thorough inspection of large collections of different species of Nesiotites from the Balearic Islands reveals wide intraspecific morphological variation within these Plio-Pleistocene shrews. Six out of seven diagnostic characters of N. rafelinensis fall within the variability of the oldest species previously known, N. ponsi. We thus conclude that no traits sufficiently support the definition of a new species, and in our opinion this material should be better referred to N. ponsi or to a closely related form (N. aff. ponsi / N. cf. ponsi). Marc Furió . Institut Català de Paleontologia M. Crusafont, Edifici ICP, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193, Barcelona, Spain. marc.furio@icp.cat Guillem Pons-Monjo. Institut Català de Paleontologia M. Crusafont, Edifici ICP, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193, Barcelona, Spain. guillem.pons@icp.cat
Reuse of waste carbon fibre by compounding with thermoplastic polymers

Composites of Polypropylene (PP) and High Density Polyethylene (HDPE) with three types of continuous sized waste carbon fibres (CF) were manufactured using twin screw compounding. The carbon fibres used were collected as waste product form the 3D weaving process. Compounds with various percentages, between 4.6 % and 15.5 % fibre volume fraction, of reinforcement were injection moulded. Tensile testing was carried out to access the change in Young’s modulus, tensile strength and elongation at break. Also, micrographic analysis was conducted to observe the importance of sizing and the effect of its removal. It was determined that the Young’s modulus and tensile strength of the composite increased with increasing carbon fibre loading, whereas the elongation at break was reduced. Also, it was determined that an increase in tensile strength could be obtained by removal of the epoxy size.
A study of long wave run-ups on a bi-linear beach slope induced by solitary and transient-focused wave group

ABSTRACT This paper presents long wave run-ups and rundowns on a bi-linear slope beach detected by using an image processing technique. For long wave run-ups, solitary wave run-up is obtained through experimental tests by Hydraulic-Control Wave-maker (HCW) and the dataset are validated by comparing Open-Source field Operation and Manipulation (OpenFOAM) with Reynolds Averaged Navier-Stokes (RANS)-type model and COrnell University Long and intermediate WAVE modelling package (COULWAVE) with Boussinesq-type model. For infragravity wave run-up, furthermore, a transient-focused wave group are generated and validated by the comparison of the numerical simulations. The results present not only that a low-frequency waves are enhanced by shoaling and breaking processes due to the bi-linear slope beach compare to the analytical solution on plane beach but that the series of wave run-ups are dominant by the low-frequency wave induced by the transient-focused wave groups.
Association Between WIC Enrollment and Exclusive Breastfeeding at 3 Months Postpartum Among Low-Income Mothers

Abstract Context: Existing literature suggests participation in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in the prenatal and postnatal periods is associated with lower rates of breastfeeding among WIC-eligible mothers. However, minimal research has been published on the association between WIC enrollment and exclusive breastfeeding. Objective: To examine the association between WIC exposure and exclusive breastfeeding at 3 months postpartum. Methods: We conducted a secondary data analysis using information on 784 low-income women who participated in the longitudinal population-based Infant Feeding Practices Study II between May 2005 and June 2007. The main outcome of interest was exclusive breastfeeding at 3 months postpartum. Logistic regression analysis was used to estimate OR and 95% CI for exclusive breastfeeding relative to WIC enrollment status, controlling for the confounding effects of other maternal characteristics. We further conducted a subgroup analysis among those participating in WIC prenatally to examine the association between receipt of information about infant feeding from WIC and exclusive breastfeeding at 3 months postpartum. Results: The crude prevalence of exclusive breastfeeding at 3 months postpartum was 18.1% of women enrolled in WIC and 41.1% of WIC-eligible nonparticipants (P<.0001). After adjusting for sociodemographic, behavioral, and anthropometric factors, the odds of exclusive breastfeeding at 3 months were lower for women enrolled in WIC (OR, 0.57; 95% CI, 0.37-0.88) when compared with women not enrolled in WIC. In the subgroup analysis, receipt of information from WIC about feeding infants during the prenatal period was not significantly associated with exclusive breastfeeding at 3 months (OR, 0.86; 95% CI, 0.39-1.89). Conclusion: Women who were enrolled in WIC and who received information about feeding infants were less likely to exclusively breastfeed than women not in WIC. Continued improvement and adjustment to the existing WIC breastfeeding program could potentially improve these rates. Additional studies that examine the quality of WIC services provided, especially those pertaining to breastfeeding programs, are warranted.
Spatial arrangement and macrodomain organization of bacterial chromosomes

Recent developments in fluorescence microscopy have shown that bacterial chromosomes have a defined spatial arrangement that preserves the linear order of genes on the genetic map. These approaches also revealed that large portions of the chromosome in Escherichia coli or Bacillus subtilis are concentrated in the same cellular space, suggesting an organization as large regions defined as macrodomains. In E. coli, two macrodomains of 1 Mb containing the replication origin (Ori) and the replication terminus (Ter) have been shown to relocalize at specific steps of the cell cycle. A genetic analysis of the collision probability between distant DNA sites in E. coli has confirmed the presence of macrodomains by revealing the existence of large regions that do not collide with each other. Two macrodomains defined by the genetic approach coincide with the Ori and Ter macrodomains, and two new macrodomains flanking the Ter macrodomain have been identified. Altogether, these results indicate that the E. coli chromosome has a ring organization with four structured and two less‐structured regions. Implications for chromosome dynamics during the cell cycle and future prospects for the characterization and understanding of macrodomain organization are discussed.
Controlling a Multicenter Outbreak Involving the New York/Japan Methicillin-Resistant Staphylococcus aureus Clone

Objective. To describe the control of an outbreak of infection and colonization with the New York/Japan methicillin-resistant Staphylococcus aureus (MRSA) clone in multiple healthcare facilities, and to demonstrate the importance of making an MRSA management policy involving molecular typing of MRSA into a statewide public health responsibility. Setting. A range of healthcare facilities, including 2 metropolitan teaching hospitals and a regional hospital, as well as several community hospitals and long-term care facilities in a nonmetropolitan healthcare region. Interventions. A comprehensive, statewide MRSA epidemiological investigation and management policy. Results. In May 2005, there were 3 isolates referred to the Western Australian Gram-Positive Bacteria Typing and Research Unit that were identified as the New York/Japan MRSA clone, a pandemic MRSA clone with the ability to spread and replace existing clones in a region. Subsequent investigation identified 28 additional cases of infection and/or colonization dating from 2002 onward, including 1 involving a colonized healthcare worker (HCW) who had previously been hospitalized overseas. Of the 31 isolates detected, 25 were linked epidemiologically and via molecular typing to the isolate recovered from the colonized HCW. Four isolates appeared to have been introduced separately from overseas. Although the isolate from the single remaining case patient was genetically indistinct from the isolates that spread within Western Australia, no specific epidemiological link could be established. The application of standard outbreak management strategies reduced further spread. Conclusions. The elimination of the New/York Japan MRSA clone in a healthcare region demonstrates the importance of incorporating MRSA management policy into statewide public health programs. The mainstays of such programs should include a comprehensive and effective outbreak identification and management policy (including pre-employment screening of HCWs, where applicable) and MRSA clone identification by multilocus sequence typing.
A Grapevine Anthocyanin Acyltransferase, Transcriptionally Regulated by VvMYBA, Can Produce Most Acylated Anthocyanins Present in Grape Skins1

An anthocyanin acyltransferase with an unusual substrate flexibility is truncated in cv Pinot Noir, a grapevine cultivar lacking acylated red pigments. Anthocyanins are flavonoid compounds responsible for red/purple colors in the leaves, fruit, and flowers of many plant species. They are produced through a multistep pathway that is controlled by MYB transcription factors. VvMYBA1 and VvMYBA2 activate anthocyanin biosynthesis in grapevine (Vitis vinifera) and are nonfunctional in white grapevine cultivars. In this study, transgenic grapevines with altered VvMYBA gene expression were developed, and transcript analysis was carried out on berries using a microarray technique. The results showed that VvMYBA is a positive regulator of the later stages of anthocyanin synthesis, modification, and transport in cv Shiraz. One up-regulated gene, ANTHOCYANIN 3-O-GLUCOSIDE-6″-O-ACYLTRANSFERASE (Vv3AT), encodes a BAHD acyltransferase protein (named after the first letter of the first four characterized proteins: BEAT [for acetyl CoA:benzylalcohol acetyltransferase], AHCT [for anthocyanin O-hydroxycinnamoyltransferase], HCBT [for anthranilate N-hydroxycinnamoyl/benzoyltransferase], and DAT [for deacetylvindoline 4-O-acetyltransferase]), belonging to a clade separate from most anthocyanin acyltransferases. Functional studies (in planta and in vitro) show that Vv3AT has a broad anthocyanin substrate specificity and can also utilize both aliphatic and aromatic acyl donors, a novel activity for this enzyme family found in nature. In cv Pinot Noir, a red-berried grapevine mutant lacking acylated anthocyanins, Vv3AT contains a nonsense mutation encoding a truncated protein that lacks two motifs required for BAHD protein activity. Promoter activation assays confirm that Vv3AT transcription is activated by VvMYBA1, which adds to the current understanding of the regulation of the BAHD gene family. The flexibility of Vv3AT to use both classes of acyl donors will be useful in the engineering of anthocyanins in planta or in vitro.
A Case with Small Cell Carcinoma of the Lung Expressing Alpha-Smooth Muscle Actin

An 80-year-old man was admitted to hospital on June 16th, 1994, for closer examination of right-sided chest pain. Chest roentgenograms and computed tomograms (Fig. 1) showed multiple tumors of the right side of the chest and abdominal walls as well as swelling of mediastinal lymph nodes. Physical examination revealed a thumb-sized subcutaneous mass of the right lateral chest region, and laboratory data showed abnormal values of serum LDH, 252 IU/L ( < 220 IU/L), CEA, 6.9 ng/ml ( < 6.7 ng/ml), and NSE, 18.3 ng/ml ( < 10 ng/ml). The histologic diagnosis of the biopsied specimen obtained from the subcutaneous mass was small cell carcinoma, intermediate cell type. In the immunohistochemical study, the tumor showed
Testing the Expectations Hypothesis When Interest Rates are Near Integrated

Nominal interest rates are unlikely to be generated by unit-root processes. Using data on short and long interest rates from eight developed and six emerging economies, we test the expectations hypothesis using cointegration methods under the assumption that interest rates are near integrated. If the null hypothesis of no cointegration is rejected, we then test whether the estimated cointegrating vector is consistent with that suggested by the expectations hypothesis. The results show support for cointegration in 10 of the 14 countries we consider, and the cointegrating vector is similar across countries. However, the parameters differ from those suggested by theory. We relate our findings to existing literature on the failure of the expectations hypothesis and to the role of term premia.
Generation and Impact of Neural Invasion in Pancreatic Cancer

Pancreatic cancer (PCa) as one of the most aggressive malignancies of mankind has an unparallelled propensity to invade intrapancreatic nerves. This “neural invasion” is therefore one of the most frequent routes of spread in PCa in addition to lymphatic and vascular paths. The major clinical relevance of neural invasion (NI) has triggered intense research efforts to understand its pathomechanims, and the findings derived from all these studies show how multi-faceted this peculiar route of cancer invasion in PCa is. This chapter is devoted to a thorough description of the characteristics, the pathomechanism and the clinical impact of NI in PCa, with the discussion of the most important pathways which may be future targets for therapeutic intervention.
A Double-blind Controlled Pilot Study of Plasma Exchange versus Sham Apheresis in Chronic Progressive Multiple Sclerosis

ABSTRACT: Twenty patients with chronically progressive multiple sclerosis (MS) were randomised in a double-blind controlled study to assess the efficacy of plasma exchange therapy. All patients were immunosuppressed with prednisone and azathioprine and underwent either plasma exchange or sham apheresis. The 10 patients in each group were similar in age, sex, duration of disease and degree of disability. Clinical and laboratory responses were assessed immediately following the course of exchange or sham therapy, and 3 to 6 months later, by individuals blinded to the type of therapy administered. Although modest improvement was suggested on clinical examination in 7 of 10 patients exchanged and 3 of the 10 sham treated group, this was transient and was not accompanied by any change in disability status scores. No differences in abnormal laboratory investigations were demonstrable between the two patient groups following therapy. We conclude that plasma exchange therapy using this protocol is unlikely to be of clinical benefit as an adjunct in the management of chronically progressive M.S.
Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer

Resistance to docetaxel is a major clinical problem in advanced prostate cancer (PCa). Although glucocorticoids (GCs) are frequently used in combination with docetaxel, it is unclear to what extent GCs and their receptor, the glucocorticoid receptor (GR), contribute to the chemotherapy resistance. In this study, we aim to elucidate the role of the GR in docetaxel-resistant PCa in order to improve the current PCa therapies. GR expression was analyzed in a tissue microarray of primary PCa specimens from chemonaive and docetaxel-treated patients, and in cultured PCa cell lines with an acquired docetaxel resistance (PC3-DR, DU145-DR, and 22Rv1-DR). We found a robust overexpression of the GR in primary PCa from docetaxel-treated patients and enhanced GR levels in cultured docetaxel-resistant human PCa cells, indicating a key role of the GR in docetaxel resistance. The capability of the GR antagonists (RU-486 and cyproterone acetate) to revert docetaxel resistance was investigated and revealed significant resensitization of docetaxel-resistant PCa cells for docetaxel treatment in a dose- and time-dependent manner, in which a complete restoration of docetaxel sensitivity was achieved in both androgen receptor (AR)-negative and AR-positive cell lines. Mechanistically, we demonstrated down-regulation of Bcl-xL and Bcl-2 upon GR antagonism, thereby defining potential treatment targets. In conclusion, we describe the involvement of the GR in the acquisition of docetaxel resistance in human PCa. Therapeutic targeting of the GR effectively resensitizes docetaxel-resistant PCa cells. These findings warrant further investigation of the clinical utility of the GR antagonists in the management of patients with advanced and docetaxel-resistant PCa.
Estimated migration rates under scenarios of global climate change

Greenhouse‐induced warming and resulting shifts in climatic zones may exceed the migration capabilities of some species. We used fourteen combinations of General Circulation Models (GCMs) and Global Vegetation Models (GVMs) to investigate possible migration rates required under CO2‐doubled climatic forcing.