Miracle-dz/UniFAR-FTUs huggingface dataset:
[Endovascular treatment of diseases of the descending thoracic aorta].

INTRODUCTION Endovascular repair as treatment of aortic diseases seems promising. We report the first Danish results of endografting of the descending thoracic aorta. MATERIALS AND METHODS Nineteen patients (median age 68 years, range 22-78 years) underwent endovascular treatment of diseases in the descending thoracic aorta: atherosclerotic aneurysm (n = 7), ruptured aneurysm (n = 3), Type B dissection (n = 3), traumatic rupture (n = 3), pseudoaneurysm (n = 2) and a defective aortic prosthesis (n = 1). The patients were followed with chest CT scans and clinically. RESULTS In all cases the endograft was successfully deployed in the intended positions. Median total hospital stay was 5 days, range 2-21 days. Eight patients had post-implantation syndrome. No deaths occurred within the first post-operative month. During the follow-up period (median 12 months, range 1-56 months) five deaths were observed. One of the patients died from aortobronchial fistula related to the endograft. One patient had an endoleak, and two had expanded aneurysm. None of these patients was treated. CONCLUSION In selected patients, endoluminal grafting of the descending thoracic aortic is a safe and successful alternative to open graft repair in treating aneurysm, ruptured aneurysm, traumatic rupture and dissection. However, long-term evaluation is still required.
Affective Stories: Understanding the Lack of Progress of Women Faculty

Previous research has found that the problem of sex inequity in higher faculty ranks may result from women taking longer to advance past associate professor. While statistical reports can isolate trends, they cannot identify reasons why women advance more slowly or suggest solutions for the situation. In this study, we conducted focus groups to learn how women tenured associate professors perceive their status as faculty women and their progress toward advancement to full professor. Questions explored career-related beliefs and practices, feelings about career progress, issues encountered while in the academy, and strategies used to manage these issues. Qualitative analysis of recurring themes and self-narratives of participants suggests that women associate professors are an overlooked or "forgotten" group. Evidence refutes the common wisdom that the number of senior women faculty will grow if more women are hired at the junior levels. Women in the study expressed lack of agency and resignation to their status and felt demoralized based on their experiences in the academy. Recommendations to address the "accumulation of disadvantages" are proposed including consistent application of promotion policies, development of workshops educating women about issues regarding their advancement, and equitable support for the activities of women faculty.
Small ncRNA transcriptome analysis from Aspergillus fumigatus suggests a novel mechanism for regulation of protein synthesis

Small non-protein-coding RNAs (ncRNAs) have systematically been studied in various model organisms from Escherichia coli to Homo sapiens. Here, we analyse the small ncRNA transcriptome from the pathogenic filamentous fungus Aspergillus fumigatus. To that aim, we experimentally screened for ncRNAs, expressed under various growth conditions or during specific developmental stages, by generating a specialized cDNA library from size-selected small RNA species. Our screen revealed 30 novel ncRNA candidates from known ncRNA classes such as small nuclear RNAs (snRNAs) and C/D box-type small nucleolar RNAs (C/D box snoRNAs). Additionally, several candidates for H/ACA box snoRNAs could be predicted by a bioinformatical screen. We also identified 15 candidates for ncRNAs, which could not be assigned to any known ncRNA class. Some of these ncRNA species are developmentally regulated implying a possible novel function in A. fumigatus development. Surprisingly, in addition to full-length tRNAs, we also identified 5′- or 3′-halves of tRNAs, only, which are likely generated by tRNA cleavage within the anti-codon loop. We show that conidiation induces tRNA cleavage resulting in tRNA depletion within conidia. Since conidia represent the resting state of A. fumigatus we propose that conidial tRNA depletion might be a novel mechanism to down-regulate protein synthesis in a filamentous fungus.
Implicit learning and consciousness: A graded, dynamic perspective

na a a am m m mi i i ic c c c p p p pe e e er r r rs s s sp p p pe e e ec c c ct t t ti i i iv v v ve e e e While the study of implicit learning is nothing new, the field as a whole has come to embody — over the last decade or so — ongoing questioning about three of the most fundamental debates in the cognitive sciences: The nature of consciousness, the nature of mental representation (in particular the difficult issue of abstraction), and the role of experience in shaping the cognitive system. Our main goal in this chapter is to offer a framework that attempts to integrate current thinking about these three issues in a way that specifically links consciousness with adaptation and learning. Our assumptions about this relationship are rooted in further assumptions about the nature of processing and of representation in cognitive systems. When considered together, we believe that these assumptions offer a new perspective on the relationships between conscious and unconscious processing and on the function of consciousness in cognitive systems. To begin in a way that reflects the goals of this volume, we can ask the question: " What is implicit learning for? " In asking this question, one presupposes that implicit learning is a special process that can be distinguished from, say, explicit learning or, even more pointedly, from learning tout court. The most salient feature attributed to implicit learning is of course that it is implicit, by which most researchers in the area actually mean unconscious. Hence the question "What is implicit learning for? " is in fact a way of asking about the function of consciousness in learning that specifically assumes that conscious and unconscious learning have different functions. The central idea that we will develop in this chapter is that conscious and unconscious learning are actually two different expressions of a single set of constantly operating graded, dynamic processes of adaptation. While this position emphasizes that conscious and unconscious processing differ only in degree rather than in kind, it is nevertheless not incompatible with the notion that consciousness has specific functions in the cognitive economy. Indeed, our main conclusion will be that the function of consciousness is to offer flexible adaptive control over behavior. By adaptive here, we do not mean simply the …
Cost-Utility Analysis of Total Hip Arthroplasties: Technology Assessment of Surgical Procedures by Mailed Questionnaires

Abstract A retrospective study comparing 700 consecutive total hip arthroplasties, utilizing four types of implants, was performed. Questionnaires based on hip scores were sent to 593 living patients. Useful responses were received from 363 (61 %) patients. Hip scores and quality-adjusted life-years were calculated. Multiple regression analysis, controlling for all possible biases, demonstrated one cementless implant as superior to all others. We believe that the use of mailed questionnaires is a simple and convenient system of follow-up, saving patients the need for outpatient clinic visits. The validity of such replies, however, has yet to be established.
Rapid Scout: bridging the gulf between physical and virtual environments

We explored how to bridge the gulf between physical and virtual environments for the sport of whitewater paddling. Field observations, critical incident analysis, exploratory prototyping, and field and lab evaluations were used to make discoveries. Lessons learned in this ethnographic process led to the design of a guiding, communication, and navigation aid for kayakers and canoeists. In designing "Rapid Scout", we gained insights on making virtual representations context-sensitive, coupling multiple perspectives, dealing with uncertainty, and extending human views. Ways to facilitate collaboration through shared graphic frames of reference were also explored.
Developmental amnesia: Effect of age at injury

Hypoxic–ischemic events sustained within the first year of life can result in developmental amnesia, a disorder characterized by markedly impaired episodic memory and relatively preserved semantic memory, in association with medial temporal pathology that appears to be restricted to the hippocampus. Here we compared children who had hypoxic–ischemic events before 1 year of age (early group, n = 6) with others who showed memory problems after suffering hypoxic–ischemic events between the ages of 6 and 14 years (late group, n = 5). Morphometric analyses of the whole brain revealed that, compared with age-matched controls, both groups had bilateral abnormalities in the hippocampus, putamen, and posterior thalamus, as well as in the right retrosplenial cortex. The two groups also showed similar reductions (≈40%) in hippocampal volumes. Neuropsychologically, the only significant differences between the two were on a few tests of immediate memory, where the early group surpassed the late group. The latter measures provided the only clear indication that very early injury can lead to greater functional sparing than injury acquired later in childhood, due perhaps to the greater plasticity of the infant brain. On measures of long-term memory, by contrast, the two groups had highly similar profiles, both showing roughly equivalent preservation of semantic memory combined with marked impairment in episodic memory. It thus appears that, if this selective memory disorder is a special syndrome related to the early occurrence of hypoxia-induced damage, then the effective age at injury for this syndrome extends from birth to puberty.
Racial/Ethnic Differences in the Associations Between Physical Activity and Sleep Duration: A Population-Based Study.

BACKGROUND This study examined associations between physical activity (recreational, nonrecreational) and sleep duration among a nationally representative diverse sample of U.S. adults. METHODS We used cross-sectional data from 9,205 National Health and Nutrition Examination Survey 2007 to 2012 participants aged 20 to 65 years who identified as White, Black, or Hispanic. Activity (ie, recreation, occupation, and transportation activity) was categorized into quartiles. Sleep duration was categorized as short (≤6 hours/night) or normal (>6 to ≤9 hours/night). Logistic regression was used to estimate associations of activity with sleep duration. RESULTS Recommended levels of recreation activity and moderate levels of transportation activity were associated with normal sleep duration [Odds Ratio (OR): = 1.33, 95% Confidence Interval (CI) = 1.08, 1.65; OR = 1.28, 95% CI = 1.02, 1.62, respectively]. High occupation physical activity was associated with shorter sleep duration (OR = 0.59, 95% CI = 0.49, 0.71). Differences were observed by race/ethnicity in associations of recreation and occupation activity with sleep duration. CONCLUSIONS White individuals who engaged in some recreation activity, relative to being inactive, had more favorable sleep duration; whereas, high levels of occupation activity were associated with worse sleep duration among White and Black individuals. Physical activity was not associated with sleep duration among Hispanics.
Antimicrobial properties of lactic acid bacteria isolated from uruguayan artisan cheese

Uruguayan artisan cheese is elaborated with raw milk and non-commercial starters. The associated native microbiota may include lactic acid bacteria and also potentially pathogenic bacteria. Lactic acid bacteria were isolated from artisan cheese, raw milk, and non-commercial starter cultures, and their potential bacteriocin production was assessed. A culture collection of 509 isolates was obtained, and five isolates were bacteriocin-producers and were identified as Enterococcus durans, Lactobacillus casei, and Lactococcus lactis. No evidence of potential virulence factors were found in E. durans strains. These are promising results in terms of using these native strains for cheese manufacture and to obtain safe products.
The age of discontinuity - guidelines to our changing society

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Cutting Edge: Differential Expression of Chemokines in Th1 and Th2 Cells Is Dependent on Stat6 But Not Stat41

The in vivo function of Th cell subsets is largely dependent on the ability of differentiated CD4+ T cells to be recruited to specific sites and secrete restricted sets of cytokines. In this paper we demonstrate that Th1 and Th2 cells secrete discrete patterns of chemokines, small m.w. cytokines that function as chemoattractants in inflammatory reactions. Th2 cells secrete macrophage-derived chemokine and T cell activation gene 3, and acquisition of this pattern of expression is dependent on Stat6. In contrast, Th1 cells secrete lymphotactin and RANTES, though unlike IFN-γ, expression of these chemokines is independent of Stat4. We further show that supernatants from activated Th2 cells preferentially induce the chemotaxis of Th2 over Th1 cells, corresponding with Stat6-dependent expression of CCR4 and CCR8 in Th2 cells. These data provide the basis for restricted and direct T cell-mediated cellular recruitment to sites of inflammation.
Extreme Sports

Extreme sports and extreme sports participants have been most commonly explored from a negative perspective, for example, the “need to take unnecessary risks. ” This study explored what can be learned from extreme sports about courage and humility—two positive psychology constructs. A phenomenological method was used via unstructured interviews with 15 extreme sports participants and other firsthand accounts. The extreme sports included BASE (building, antenna, span, earth) jumping, big wave surfing, extreme skiing, waterfall kayaking, extreme mountaineering, and solo rope-free climbing. Results indicate that humility and courage can be deliberately sought out by participating in activities that involve a real chance of death, fear, and the realization that nature in its extreme is far greater and more powerful than humanity.
Elbow Joint Active Replication in College Pitchers Following Simulated Game Throwing

Background: Elbow injuries are common in college baseball players. Pitching creates stress and fatigue in and around the elbow. Lack of joint proprioception can contribute to nonphysiological joint loading and injury. Hypothesis: There will be no difference in elbow joint active reproduction sense following a simulated 3-inning pitching sequence. Study Design: Cross-sectional study. Methods: Seventeen collegiate pitchers participated. Each pitcher was bilaterally tested for active elbow range of motion using goniometric technique. Percentages of motion determined positions for further study of elbow joint active replication sense (20%, 35%, 50%, 80%). The elbow was passively taken to a position and held for 10 seconds, then returned to full extension. Pitchers were asked to actively reproduce the angle. The opposite elbow was tested in the same manner. One week later, prethrowing joint position reproduction was tested; then a simulated 3-inning game was thrown. Immediately afterward, elbow joint active replication testing was performed. A repeated-measures analysis of variance analyzed differences. Results: No change in active joint reproduction occurred in the nondominant elbow at any angle tested. Dominant elbows demonstrated significant losses of active joint reproduction following throwing. Significant differences occurred at the 35% and 80% angles (P < .05). Conclusion: Active elbow joint replication sense may be compromised following 3 innings of throwing. Because joint proprioception is thought to be an important component of joint stabilization, an alteration in joint position sense may increase the risk of elbow injury during throwing. Clinical Relevance: Pitching may cause a loss of active elbow joint replication.
Arithmetic and growth of periodic orbits

Two natural properties of integer sequences are introduced and studied. The first, exact realizability, is the property that the sequence coincides with the number of periodic points under some map. This is shown to impose a strong inner structure on the sequence. The second, realizability in rate, is the property that the sequence asymptotically approximates the number of periodic points under some map. In both cases we discuss when a sequence can have that property. For exact realizability, this amounts to examining the range and domain among integer sequences of the paired transformations that move between an arbitrary sequence of non-negative integers Orb counting the orbits of a map and the sequence Per of periodic points for that map. Several examples from the Encyclopedia of Integer Sequences arise in this work, and a table of sequences from the Encyclopedia known or conjectured to be exactly realizable is given.
Factors Influencing the Adoption of Internet Banking

A research framework based on the theory of planned behavior (Ajzen 1985) and the diffusion of innovations theory (Rogers 1983) was used to identify the attitudinal, social and perceived behavioral control factors that would influence the adoption of Internet banking. An online questionnaire was designed on the World Wide Web (WWW). Respondents participated through extensive personalized email invitations as well as postings to newsgroups and hyperlinks from selected Web sites.
Pectin‐like carbohydrates in the green alga Micrasterias characterized by cytochemical analysis and energy filtering TEM

Pectins are the major matrix polysaccharides of plant cell walls and are important for controlling growth, wall porosity and regulation of the ionic environment in plant cells. Pectic epitopes recognized by the monoclonal antibodies JIM5, JIM7 and 2F4 could be localized in the primary wall during development of the green alga Micrasterias. As the degree of pectin esterification determines the calcium‐binding capacity and thus the physical properties of the cell wall, chemical and enzymatic in situ de‐esterification was performed. This resulted in displacement of epitopes recognized by JIM5, JIM7 and 2F4, respectively, in changes in the intensity of the antibody labelling as visualized in CLSM. In addition, calcium‐binding capacities of cell walls and components of the secretory apparatus were determined in transmission electron microscopy by electron energy loss spectroscopy and electron spectroscopic imaging. These analyses revealed that pectic polysaccharides are transported to the cell wall in a de‐esterified form. At the primary wall, pectins get methyl‐esterified at the inner side, thus allowing flexibility of the wall. At the outer side of the wall they become again de‐esterified and bind high amounts of calcium which leads to cell wall stiffening. Mucilage vesicles posses the highest calcium‐binding capacity of all structures observed in Micrasterias, indicating that the pectic polysaccharides of mucilage are secreted in a de‐esterified, compact form. When mucilage is excreted through the cell wall, it loses its ability to bind calcium. The esterification of pectins involved is obviously required for swelling of mucilage by water uptake, which generates the motive force for orientation of this unicellular organism in respect to light. Incubation of Micrasterias in pectin methylesterase (PME), which de‐esterifies pectic polymers in higher plants, resulted in growth inhibition, cell shape malformation and primary wall thickening. A PME‐like enzyme could be found in Micrasterias by PME activity assays.
Stimulation of the proliferation and differentiation of mouse pink‐eyed dilution epidermal melanocytes by excess tyrosine in serum‐free primary culture

The epidermal cell suspensions of the neonatal dorsal skin derived from wild type mouse at the pink‐eyed dilution (p) locus (black, C57BL/10JHir‐P/P) and their congenic mutant mouse (pink‐eyed dilution, C57BL/10JHir‐p/p) were cultured with a serum‐free melanocyte growth medium supplemented with additional L‐tyrosine (Tyr) from initiation of the primary culture. L‐Tyr inhibited the proliferation of P/P melanocytes in a dose‐dependent manner, whereas L‐Tyr stimulated the proliferation of p/p melanoblasts and melanocytes regardless of dose. On the other hand, L‐Tyr stimulated (P/P) or induced (p/p) the differentiation of epidermal melanocytes in a dose‐dependent manner. In both P/P and p/p melanoblasts and melanocytes cultured with 2.0 mM L‐Tyr for 14 days, slight increases in contents of eumelanin marker, pyrrole‐2,3,5‐tricarboxylic acid (PTCA) and pheomelanin marker, aminohydroxyphenylalanine (AHP) were observed. The average number of total melanosomes (stages I, II, III, and IV) per P/P melanocyte was not changed by L‐Tyr treatment, but the proportion of stage IV melanosomes in the total melanosomes was increased. On the contrary, in p/p melanoblasts and melanocytes L‐Tyr increased dramatically the number of stage II, III, and IV melanosomes as well as the proportion of stage III melanosomes. Contents of PTCA and eumelanin precursor, 5,6‐dihydroxyindole‐2‐carboxylic acid (DHICA) of cultured media in p/p melanocytes were much more greatly increased than in P/P melanocytes. However, contents of AHP and pheomelanin precursor, 5‐S‐cysteinyldopa (5‐S‐CD) of cultured media in p/p melanocytes were increased in a similar tendency to P/P melanocytes. These results suggest that p/p melanocytes in the primary culture are induced to synthesize eumelanin by excess L‐Tyr, but difficult to accumulate them in melanosomes. J. Cell. Physiol. 191: 162–172, 2002. © 2002 Wiley‐Liss, Inc.