Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomechanical Properties of the Cornea Measured With the Dynamic Scheimpflug Analyzer in Young Healthy Adults

Purpose: To investigate the biomechanical properties of the cornea using the dynamic Scheimpflug analyzer in young healthy adults. Methods: This prospective cross-sectional population study included 944 eyes of 472 participants aged 20 to 40 years. Participants underwent ophthalmic investigations, including evaluation of biomechanical properties of the cornea using the dynamic Scheimpflug analyzer, manifest refraction, and measurements of keratometric values by autokeratometry, intraocular pressure (IOP) by noncontact tonometer, central corneal thickness (CCT) by ultrasound, and white-to-white distance by Scheimpflug tomography. Statistical analyses included determination of the reference interval with a bootstrapping method, linear quantile mixed-effects model, and Spearman correlation analysis between the corneal biomechanical parameters and other variables (age, manifest refraction spherical equivalent, CCT, IOP, white-to-white, and keratometric values). Results: The 90% CIs of all corneal biomechanical parameters demonstrated that the ranges of the 90% CIs for the reference data were almost identical with and without bootstrapping. Quantile regression to determine the fifth, 50th, and 95th percentiles of each corneal biomechanical parameter supported the findings from the nonparametric method with the 90% CIs. Correlation analysis showed significant correlations between the parameters and variables, but there was a relatively high Spearman correlation coefficient in the case of the correlations with the CCT and IOP. Conclusions: Using data from a large population of young healthy adults, we developed a database of normal values for multiple corneal biomechanical parameters obtained from the dynamic Scheimpflug analyzer. We conclude that the biomechanical properties of the cornea are influenced by the CCT and IOP.
Upper-mantle anisotropy beneath the Cameroon Volcanic Line and Congo Craton from shear wave splitting measurements

SUMMARY The Cameroon Volcanic Line (CVL) is an 1800-km-long line of Cenozoic volcanoes that does not show a chronological progression consistent with hotspot-related volcanism. We investigate seismic anisotropy to determine the upper-mantle lattice preferred orientation and constrain the mantle flow pattern using a temporary array of 32 broad-band seismographs deployed throughout Cameroon between 2005 and 2007 along with two additional permanent seismographs in adjacent countries. We determine the fast direction and lag time beneath each station by stacking SKS and SKKS splitting measurements from multiple events. The results indicate four regions with different splitting parameters. The Congo Craton in southern Cameroon and the Garoua rift region in northeast Cameroon have northeast–southwest-oriented fast directions and split times of about 1 s. Between the Congo Craton and the CVL, in central Cameroon, the fast directions are variable and have small splitting times of 0.3 s or less. Along the CVL, where previous studies show a strong slow velocity anomaly in the mantle, the fast direction is oriented approximately north–south, with splitting times of about 0.7 s. We interpret measurements from southern Cameroon and northeast Cameroon as indications of lattice-preferred orientation frozen into the Congo Craton and subcontinental lithosphere related to relict plate motion and deformation. The distinct pattern of splitting along the CVL suggests the existence of small-scale convection in the asthenosphere related to the formation of the CVL, perhaps driven by the adjacent cold edge of the Congo Craton.
Hop Client-Side Compilation

Hop is a new language for programming interactive Web applications. It aims to replace HTML, JavaScript, and server-side scripting languages (such as PHP, JSP) with a unique language that is used for client-side interactions and server-side computations. A Hop execution platform is made of two compilers: one that compiles the code executed by the server, and one that compiles the code executed by the client. This paper presents the latter. In order to ensure compatibility of Hop graphical user interfaces with popular plain Web browsers, the client-side Hop compiler has to generate regular HTML and JavaScript code. The generated code runs roughly at the same speed as handwritten code. Since the Hop language is built on top of the Scheme programming language, compiling Hop to JavaScript is nearly equivalent to compiling Scheme to JavaScript. SCM2JS, the compiler we have designed, supports the whole Scheme core language. In particular, it features proper tail recursion. However complete proper tail recursion may slow down the generated code. Despite an optimization which eliminates up to 40% of instrumentation for tail call intensive benchmarks, worst case programs were more than two times slower. As a result Hop only uses a weaker form of tail-call optimization which simplifies recursive tail-calls to while-loops. The techniques presented in this paper can be applied to most strict functional languages such as ML and Lisp. SCM2JS can be downloaded at http://www-sop.inria.fr/mimosa/personnel/Florian.Loitsch/scheme2js/. It is also distributed along with Hop which can be found at http://hop.inria.fr. 1Inria Sophia Antipolis, 2004 route des Lucioles BP93, F-06902 Sophia Antipolis, Cedex, France; Email: {florian.loitsch, manuel.serrano}@inria.fr
Utility of the new rheumatoid arthritis 2010 ACR/EULAR classification criteria in routine clinical care

Objectives The new 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria for rheumatoid arthritis (RA) have been designed to classify early onset RA, but has not been studied to identify RA in patients with arthritis seen in routine clinical care where correct ‘classification’ of patients, when they are not selected for having RA would be important. Design Prospective, consecutive patients cohort. Setting Outpatient clinic of a university rheumatology centre. Participants A total of 126 patients with joint symptoms were consecutively recruited. Interventions The ACR/EULAR RA criteria were applied, with questions followed by a targeted musculoskeletal exam. The gold standard for the diagnosis of RA was the primary rheumatologist's diagnosis. Primary outcome measure Number of patients with non-RA diagnosis who were classified as having RA by the new classification criteria. Results The sensitivity and specificity of the 2010 criteria in classifying RA were 97% and 55%, respectively, compared with the 1987 RA criteria which were 93% and 76%, respectively. The 2010 criteria as applied to this group of patients had a poorer positive predictive (44% vs 61%) and a similar negative predictive value (98% vs 97%) compared with the 1987 criteria. More specifically, 66.7% of systemic lupus erythematosus patients, 50% of osteoarthritis, 37.5% of psoriatic arthritis and 27.2% of others fulfilled the new criteria and could have been classified as RA. Conclusions In this, we believe, the first study to examine the new 2010 ACR/EULAR RA criteria among consecutive patients seen in routine care, we found the criteria to have low specificity, and therefore incorrectly label those as having RA when, in fact, they may have a different type of inflammatory arthritis. Physicians need to be aware of this when applying the new criteria for classifying their patients for any purpose.
A comparison of the size distribution of collagen fibrils in connective tissues as a function of age and a possible relation between fibril size distribution and mechanical properties

Data on the distribution of collagen fibril diameters in various connective tissues have been collected and analysed for common features. The diameter distributions of the collagen fibrils at birth and in the foetal stages of development are unimodal, whereas at maturity the mass-average diameter of the collagen fibrils is generally larger than at birth and the distributions of fibril sizes may be either unimodal or bimodal depending on the tissue. At senescence, few data are available but in most instances both the mean and mass-average diameters of the collagen fibrils are smaller than those at maturity and the fibril distributions are mainly bimodal. The division between tissues showing unimodal or bimodal fibril distributions at maturity does not simply relate to the type I collagen/type II collagen classification, to the distinction between orientated and unorientated material or indeed directly to the levels of stress and strain encountered by the tissue. However, there may prove to be a relation between a bimodal fibril diameter distribution at maturity and the maintenance over long periods of time of either high stress in stretched tissues or low stress in compressed tissues. It has also been noted that the width of the collagen fibril diameter distribution at birth differs between altricious and precocious animals. The ultimate tensile strength of a connective tissue and the mass-average diameter of the constituent collagen fibrils have been shown to have a positive correlation. Further, the form of the collagen fibril diameter distribution can be directly related to the mechanical properties of the tissue. In particular, it is postulated that the size distribution of the collagen fibrils is largely determined by two factors. First, if the tissue is primarily designed to have high tensile strength, then an increase in the diameter of the collagen fibrils will parallel an increase in the potential density of intrafibrillar covalent crosslinks. Consequently large collagen fibrils are predicted to have a greater tensile strength than small fibrils. Secondly, if the tissue is designed to be elastic and hence withstand creep, then a reduction in the diameter of the collagen fibrils will effectively increase the surface area per unit mass of the fibrils thus enhancing the probability of interfibrillar non-covalent crosslinks between the collagen fibrils and the components of the matrix. The idealized description given may indicate how the mechanical properties of a tissue may be interpreted in terms of the collagen fibril diameter distribution.
Azithromycin and the risk of cardiovascular death.

BACKGROUND Although several macrolide antibiotics are proarrhythmic and associated with an increased risk of sudden cardiac death, azithromycin is thought to have minimal cardiotoxicity. However, published reports of arrhythmias suggest that azithromycin may increase the risk of cardiovascular death. METHODS We studied a Tennessee Medicaid cohort designed to detect an increased risk of death related to short-term cardiac effects of medication, excluding patients with serious noncardiovascular illness and person-time during and shortly after hospitalization. The cohort included patients who took azithromycin (347,795 prescriptions), propensity-score-matched persons who took no antibiotics (1,391,180 control periods), and patients who took amoxicillin (1,348,672 prescriptions), ciprofloxacin (264,626 prescriptions), or levofloxacin (193,906 prescriptions). RESULTS During 5 days of therapy, patients taking azithromycin, as compared with those who took no antibiotics, had an increased risk of cardiovascular death (hazard ratio, 2.88; 95% confidence interval [CI], 1.79 to 4.63; P<0.001) and death from any cause (hazard ratio, 1.85; 95% CI, 1.25 to 2.75; P=0.002). Patients who took amoxicillin had no increase in the risk of death during this period. Relative to amoxicillin, azithromycin was associated with an increased risk of cardiovascular death (hazard ratio, 2.49; 95% CI, 1.38 to 4.50; P=0.002) and death from any cause (hazard ratio, 2.02; 95% CI, 1.24 to 3.30; P=0.005), with an estimated 47 additional cardiovascular deaths per 1 million courses; patients in the highest decile of risk for cardiovascular disease had an estimated 245 additional cardiovascular deaths per 1 million courses. The risk of cardiovascular death was significantly greater with azithromycin than with ciprofloxacin but did not differ significantly from that with levofloxacin. CONCLUSIONS During 5 days of azithromycin therapy, there was a small absolute increase in cardiovascular deaths, which was most pronounced among patients with a high baseline risk of cardiovascular disease. (Funded by the National Heart, Lung, and Blood Institute and the Agency for Healthcare Quality and Research Centers for Education and Research on Therapeutics.).
A novel triple therapy for ITP using high-dose dexamethasone, low-dose rituximab, and cyclosporine (TT4).

Promising reports of combination immunosuppression with high-dose dexamethasone and rituximab for the treatment of primary immune thrombocytopenia (ITP) have recently emerged. They suggest a potential to further optimize the efficacy of therapy. We investigate the use of a novel combination of conventional therapies in ITP given over 4 weeks. From 2011 to 2014, 20 patients were prospectively enrolled onto a single-arm phase 2b study to describe the safety, efficacy, and tolerability of oral dexamethasone 40 mg for days 1 to 4, oral cyclosporine 2.5 to 3 mg/kg daily for day 1 to 28, and intravenous low-dose rituximab 100 mg for days 7, 14, 21, and 28. There were no therapy-related serious adverse side effects, 6-month response rate was 60%, and treatment was well tolerated. Responders enjoyed relapse-free survivals of 92% and 76%, respectively, at 12 and 24 months. This study highlights the possibility of achieving an enduring remission from 4 weeks of therapy. This study is registered at www.anzctr. org.au (#ANZCTRN12611000015943).
Predictors of blood loss during total hip replacement surgery.

OBJECTIVE To determine total blood loss and transfusion requirements during primary total hip replacement (THR) surgery; and, to identify predictors of increased blood loss. METHODS This was a prospective cohort study of 295 consecutive patients undergoing primary THR at a 700-bed teaching hospital in Boston, Massachusetts. The main outcome measures were the total blood loss, which was defined (in units) as the initial hematocrit minus final hematocrit divided by 3 plus the number of units transfused, and the number of autologous and homologous units of blood transfused. RESULTS The mean total blood loss was 3.6 units, and the mean total units transfused was 2.1. Univariate predictors of greater total blood loss (at P < 0.05) included being male, receiving general anesthesia, and higher American Society of Anesthesiologists (ASA) class. In multiple linear regression models which controlled for demographic and clinical variables (age, race, marital status, education, smoking history, obesity, underlying disease, payor status, cemented prosthesis, comorbidity, and season of operation), being male, receiving general anesthesia, and having an ASA score of 3 predicted greater total blood loss. CONCLUSION Preoperative characteristics can help determine which patients should donate either more or less than the customary 2 units of blood.
A hybrid dialogue strategy for speech-enabled mobile commerce

Designing a dialogue strategy for speech-enabled mobile commerce is a significant challenge due to the context. This paper introduces a hybrid dialogue strategy to overcome the inflexibility of application-directed interactions while avoiding the significant recognition difficulty of a full mixed-initiative style. The system uses N-gram grammars to govern the recognition at the request segment of a dialogue, and employs an application-directed strategy at the clarification discourse segment. The paper also details generating a corpus for the N-gram grammar through a case-based reasoning approach, and constructing application-directed dialogues with decision trees. Our preliminary testing indicates the strategy is a feasible and effective solution for voice-enabling mobile commerce applications
A Practical Feasibility Study of a Novel Strategy for the Gaussian Half-Duplex Relay Channel

This paper presents a practical feasibility study of a novel two-phase three-part-message strategy for half-duplex relaying, which features superposition coding and interference-aware cancellation decoding. Aiming to analyze the performance of the proposed scheme in the non-asymptotic regime, this paper evaluates the spectral efficiency with finite block-length and discrete constellation signaling and compares it with the theoretical performance of Gaussian codes with asymptotically large block-lengths. The performance evaluation is carried out on an LTE simulation test bench. During each transmission phase, the modulation and coding scheme is adapted to the channel link qualities to enhance the overall spectral efficiency. A single-antenna source and relay, and a multi-antenna destination are assumed. The static Gaussian and two frequency selective channel models are considered for the proposed scheme. A spectral efficiency comparison with a baseline scheme (non-cooperative two-hop transmission, i.e., the source-destination link is absent) and with the point-to-point transmission strategy (no relay) is presented. The results confirm that physical-layer cooperation and multi-antennas are critical for performance enhancement in heterogeneous networks. Moreover, they show that physical layer cooperation advantages are within practical reach with existing LTE coded-modulation and interference-mitigation techniques, which are prevalent in modern user-equipment.
A comprehensive grasp taxonomy

—The goal of this work is to overview and summarize the grasping taxonomies reported in the literature. Our long term goal is to understand how to reduce mechanical complexity of anthropomorphic hands and still preserve their dexterity. On the basis of a literature survey, 33 different grasp types are taken into account. They were then arranged in a hierarchical manner, resulting in 17 grasp types.
Comparison of diode laser trans‐scleral cyclophotocoagulation versus implantation of a 350‐mm2 Baerveldt glaucoma drainage device for the treatment of glaucoma in dogs (a retrospective study: 2010‐2016)

OBJECTIVE To compare outcomes following trans-scleral cyclophotocoagulation (TSCP) and 350-mm2 Baerveldt implantation in the treatment of canine refractory glaucoma. DESIGN Retrospective case study. CASE SELECTION Client owned dogs undergoing surgical treatment of glaucoma within a veterinary referral hospital. PROCEDURES Eighty-six glaucoma surgeries were performed on 83 eyes (69 dogs) diagnosed with primary or secondary glaucoma. Medical records were retrieved, and baseline data, surgery, medications, intraocular pressures (IOPs), vision, and complications were extracted. RESULTS Fifty-four eyes (44 dogs) were treated with TSCP and placement of an anterior chamber suture shunt; 28 eyes (24 dogs) were implanted with a Baerveldt glaucoma drainage device (GDD); and four eyes (4 dogs) underwent GDD implantation after failure of TSCP to manage IOP. Following TSCP, IOP control (<20 mmHg) and vision retention occurred in 81.5% and 42.6%, respectively, for 16.1 ± 1.36 months. Following GDD implantation, 71.4% maintained IOP <20 mmHg and 69.6% maintained vision for 11.0 ± 0.94 months. IOP control without loss of vision was more likely following Baerveldt implantation (17/28; 60.7%) than TSCP (19/54; 35.2%) (P = 0.027). One eye had functional vision restored following GDD placement. IOP control without adjunctive medications was more likely following Baerveldt implantation (P = 0.02). CONCLUSIONS In this study, eyes treated with Baerveldt GDD implantation were more likely to maintain IOP control and retain vision compared to eyes treated with TSCP and placement of an anterior chamber suture shunt. Lack of formal randomization, inconsistencies in surgical techniques and TSCP protocols, and potential unmeasured confounders must be considered when extrapolating from this retrospective study.
Chandra unveils a binary Active Galactic Nucleus in Mrk 463

We analyse Chandra, XMM‐Newton and Hubble Space Telescope (HST) data of the doublenucleus Ultraluminous Infrared Galaxy (ULIRG), Mrk 463. The Chandra detection of two luminous (L2‐10 keV = 1.5 × 10 43 and 3.8 × 10 42 erg cm −2 s −1 ), unresolved nuclei in Mrk 463 indicates that this galaxy hosts a binary active galactic nucleus (AGN), with a projected separation of � 3.8 kpc (3.83 ± 0.01 arcsec). While the East nucleus was already known to be a type 2 Seyfert (and this is further confirmed by our Chandra detection of a neutral iron line), this is the first unambiguous evidence in favour of the AGN nature of the West nucleus. Mrk 463 is therefore the clearest case so far for a binary AGN, after NGC 6240.
Decreased ADP-Ribosyl Cyclase Activity in Peripheral Blood Mononuclear Cells from Diabetic Patients with Nephropathy

Aims/hypothesis. ADP-ribosyl-cyclase activity (ADPRCA) of CD38 and other ectoenzymes mainly generate cyclic adenosine 5’diphosphate-(ADP-) ribose (cADPR) as a second messenger in various mammalian cells, including pancreatic beta cells and peripheral blood mononuclear cells (PBMCs). Since PBMCs contribute to the pathogenesis of diabetic nephropathy, ADPRCA of PBMCs could serve as a clinical prognostic marker for diabetic nephropathy. This study aimed to investigate the connection between ADPRCA in PBMCs and diabetic complications. Methods. PBMCs from 60 diabetic patients (10 for type 1 and 50 for type 2) and 15 nondiabetic controls were fluorometrically measured for ADPRCA based on the conversion of nicotinamide guanine dinucleotide (NGD+) into cyclic GDP-ribose. Results. ADPRCA negatively correlated with the level of HbA1c (P = .040, R 2 = .073), although ADPRCA showed no significant correlation with gender, age, BMI, blood pressure, level of fasting plasma glucose and lipid levels, as well as type, duration, or medication of diabetes. Interestingly, patients with nephropathy, but not other complications, presented significantly lower ADPRCA than those without nephropathy (P = .0198) and diabetes (P = .0332). ANCOVA analysis adjusted for HbA1c showed no significant correlation between ADPRCA and nephropathy. However, logistic regression analyses revealed that determinants for nephropathy were systolic blood pressure and ADPRCA, not HbA1c. Conclusion/interpretation. Decreased ADPRCA significantly correlated with diabetic nephropathy. ADPRCA in PBMCs would be an important marker associated with diabetic nephropathy.