Miracle-dz/UniFAR-FTUs huggingface dataset:
Changes in women's alcoholic, antisocial, and depressive symptomatology over 12 years: A multilevel network of individual, familial, and neighborhood influences

Abstract In a sample of 273 adult women and their families, we examined the effects of women's psychopathology history, their social support, their husbands' and children's symptomatology, family stress, and neighborhood environment on their alcohol problems, antisocial behavior, and depression over a 12-year period during their 30s and early 40s. Women's alcohol problems and antisocial behavior decreased but their depression symptoms increased over time. Women's disorder history and their partners' parallel symptomatology were associated with their symptoms. For women's antisocial behavior, their own history of alcoholism and their partners' alcohol problems were also significant risk factors. Higher levels of social support were associated with lower levels of depression in women. Children's externalizing behavior was positively correlated with their mothers' alcohol problems and antisocial behavior, whereas children's internalizing behavior was positively correlated with their mothers' depression. Neighborhood residential instability was associated with higher levels of alcoholic and depressive symptomatology in women. Intervention efforts might target women with young children by improving social support, educational or professional training opportunity, access to family counseling, and neighborhood environment.
Channel assignment schemes for cooperative spectrum sensing in multi-channel cognitive radio networks

In this paper, channel assignment for spectrum sensing is studied in multi-channel cognitive radio CR networks to maximize the number of channels satisfying sensing performance called available channels. Beginning with a nonlinear integer programming problem, we derive the upper bound of optimal value through many-to-many assignment problem and then propose three algorithms for both centralized and distributed scenarios. In centralized case, a heuristic scheme is proposed based on the signal-to-noise ratios SNRs over all primary channels PCs. Then, a greedy scheme is proposed to reduce the reported information from the CRs. In distributed case, a novel scheme with multi-round operation is designed following the coalitional game theory. In each round, each CR selects some PCs based on SNRs. Then, the CRs selecting the same channel play coalitional game, and thereby, multiple games are played concurrently over multiple channels. Finally, the best coalition for each channel is chosen among the formed coalitions to perform the cooperative spectrum sensing. The simulation results show that the proposed schemes can significantly increase the number of available channels. Copyright © 2013 John Wiley & Sons, Ltd.
Human Neuroscience

implicated in attributing mental states to others (Frith and Frith, 1999, 2006). More specifically, the brain regions adults employ in processing these communicative signals are localized in the right medial prefrontal cortex and the left temporal pole (Kampe et al., 2003). These findings suggest that, in adults, the communicative intention of another person directed toward oneself is detected by the same brain region, regardless of modality. This process occurs without deliberate attention (participants were asked to detect faces with eyes closed rather than direct gaze or to detect last names rather than their own name) and it also does not depend on subsequent interaction between participants. More support for the view that mentalizing is critical for understanding ostensive communication cues comes from individuals with autism who have been shown to be impaired in their mentalizing skills and also have severe difficulties in recognizing when they are being addressed (Baron-Cohen, 2000). Indeed, lack of orienting to name and eye contact is perhaps one of the earliest signs of autism identifiable in childhood (Osterling et al., 2002). Taken together, this poses the important ontogenetic question of whether and when typically developing infants are sensitive to eye contact and own name as ostensive signals of communicative intent and more specifically, whether infants would engage brain regions (and thus cognitive processes) similar to adults when they respond to ostensive signals across modalities. Findings as to whether young infants already engage in adult-like brain processes
Genomic Organization, Phylogenetic Comparison and Differential Expression of the SBP-Box Family Genes in Grape

Background The SBP-box gene family is specific to plants and encodes a class of zinc finger-containing transcription factors with a broad range of functions. Although SBP-box genes have been identified in numerous plants including green algae, moss, silver birch, snapdragon, Arabidopsis, rice and maize, there is little information concerning SBP-box genes, or the corresponding miR156/157, function in grapevine. Methodology/Principal Findings Eighteen SBP-box gene family members were identified in Vitis vinifera, twelve of which bore sequences that were complementary to miRNA156/157. Phylogenetic reconstruction demonstrated that plant SBP-domain proteins could be classified into seven subgroups, with the V. vinifera SBP-domain proteins being more closely related to SBP-domain proteins from dicotyledonous angiosperms than those from monocotyledonous angiosperms. In addition, synteny analysis between grape and Arabidopsis demonstrated that homologs of several grape SBP genes were found in corresponding syntenic blocks of Arabidopsis. Expression analysis of the grape SBP-box genes in various organs and at different stages of fruit development in V. quinquangularis ‘Shang-24’ revealed distinct spatiotemporal patterns. While the majority of the grape SBP-box genes lacking a miR156/157 target site were expressed ubiquitously and constitutively, most genes bearing a miR156/157 target site exhibited distinct expression patterns, possibly due to the inhibitory role of the microRNA. Furthermore, microarray data mining and quantitative real-time RT-PCR analysis identified several grape SBP-box genes that are potentially involved in the defense against biotic and abiotic stresses. Conclusion The results presented here provide a further understanding of SBP-box gene function in plants, and yields additional insights into the mechanism of stress management in grape, which may have important implications for the future success of this crop.
Methods for comparison of abdominal organ location and shape in the supine and upright positions.

The location and shape variation of the liver due to postural changes has implications in the prediction of blunt abdominal trauma via computational models or other human surrogates. Although abdominal injuries make up only 3-5% of injuries in car crashes, they are often seen in serious crashes with AIS=4 injuries. This study reviews the methods used to quantify variation in the location of the liver relative to surrounding bony structures for two different postures, supine and seated. Methods to investigate shape variation in the liver between these postures are also detailed. Magnetic resonance imaging (MRI) scans of individuals representing the 50th percentile male (M50) and 5th percentile female (F05) in terms of height (M50: 175cm, F05: 150cm) and weight (M50: 78.6kg, F05: 48.1kg) were obtained in the two postures using a GE Twin Speed and a Fonar Upright MRI respectively. Images were acquired using a Fast Spoiled Gradient Recalled pulse sequence. The liver was segmented manually. Vertebral bodies and ribs from CT scans of the same individuals were placed in the MRI space using a semi-automated approach. The center of gravity (CG) was identified for the liver and vertebral bodies. Liver volume in each scan was calculated. The location of the liver was then investigated by examining distances between the center of gravity of the liver and various vertebral bodies. The average volume of the liver for M50 and F05 was found to be 1400 and 1036 cm3, with the coefficient of variance (COV) of . 76% and . 40% respectively. In the case of M50 and F05 liver movement from the supine to upright positions, the M50 liver was found to move 11.5mm and the F05 liver was found to move 19.7mm in the superior to inferior direction. In addition, the liver in the MRI supine scans was found to have a greater area of rib coverage where as less coverage of the liver was seen in the UMRI seated scans. Regarding shape change, the M50 and F05 liver were found to be compressed 11.36% and 8.13% in the Anterior-Posterior direction when comparing the supine to seated position. The studys results indicate that postural changes do affect liver location and shape, a finding that may influence computational human body modeling efforts and the development of physical human surrogates.
Estimation of Cutting Parameters in Two-Stage Piercing to Reduce Edge Strain Hardening

Edge fracture is a common problem when forming advanced high strength steels (AHSS). A particular case of edge fracture occurs during a collar forming/hole extrusion process, which is widely used in the sheet metal forming industry. This study attempts to relate the edge stretchability in collar forming to the strain hardening along the pierced edge; thus, Finite Element (FE) simulations can be used to reduce the number of experiments required to improve cutting settings for a given material and thickness. Using a complex-phase steel, CP-W 800 with thickness of 4.0 mm, a single-stage piercing operation is compared with a two-stage piercing operation, so called shaving, in terms of strains along the pierced edge, calculated by FE simulation. Results indicated that strains were reduced along the pierced edge by shaving. These results are correlated with experimental observations made at the Technical University of Munich (TUM) where better hole expansion ratios (HERs) were obtained using shaving as opposed to single-stage piercing. Moreover, in this study, the combination of cutting parameters that would generate the least edge strain hardening is evaluated based on simulation results. This approach could reduce the need for hardness measurements along the pierced edge as well as the number of experiments required to improve the shaving process.
Water-column, sediment, and in situ chronic bioassays with cladocerans.

In situ bioassays are becoming very popular for laboratory test validation and field extrapolation. Natural conditions, including environmental variables, affect the "behavior" of contaminants and, consequently, their toxicity. This work aimed to develop protocols for in situ chronic bioassays with cladocerans and to assess the ecological relevance of conventional protocols for laboratory testing (water-column and sediment). An aquatic system impacted with acid mine drainage was chosen for the study. At some stations that were contaminated with heavy metals, water-column bioassays did not reveal any toxicity, while sediment and, especially in situ bioassays, revealed a delay in reproduction and a reduction in fertility. Thus, both laboratory bioassays underestimated the actual toxicity of studied sites: sediment, besides being an important contaminant source, became significantly altered with sampling, transport, storage, and manipulation. Therefore, an extra caution is needed when interpreting laboratory results, since the extrapolation to natural systems could be a very problematic step.
An examination of regret as expressed in the life reflections of older adults : predictors of regret intensity and frequency, and association with well-being

This study focused on the experience of regret in older adults as expressed within the context of a life history framework, using quantitative and qualitative methods. The goals were to explore the differential impact of demographic, personality, dispositional and other relevant variables on frequency and intensity of lifespan regret, the impact of both intensity and frequency of regret on psychological and physical well-being of older adults, to examine regret themes and dimensions of regret as derived from an in-depth life history interview and on the basis of qualitative data, to arrive at high- and low-regret profiles that may indicate proneness to regret. This study was the first to use a lifespan-interview measure of regret with older adults as well as the Big Five and several dispositional variables, autobiographical memory and values as predictors of intensity and frequency of regret, and to control these variables in examining the impact of regret on well-being. In Phase 1 of the study, 111 older adults participated in a Life Reflection Interview that yielded measures of intensity and frequency of regret, emergent values, quality of experience of aging and physical well-being. They also completed a battery of self-report questionnaires assessing personality, dispositional optimism, intolerance of uncertainty, depression and happiness. In Phase 2, a subsample of 71 participants completed measures assessing dispositional coping, perceived control and perceived autobiographical memory. The findings show that relatively healthy, educated older adults do not have high levels of regret, that predictors of intensity and frequency differ, that more variance in intensity compared to frequency of lifespan regrets is explained by the variables, and that regret does predict indicators of psychological but not physical well-being. The results suggest that the methodology used facilitates the measurement of self-defined regret by evoking a spontaneous expression of feelings. Future research should examine if the interview process may contribute to the working through of negative life experiences by providing an opportunity for the sharing and discussion of regrets with an interested and involved listener. Research should also focus on the identification of older adults who may be at risk.
3D Face Recognition Using Geodesic PZM Array from a Single Model per Person

For the 3D face recognition numerous methods have been proposed, but little attention has been given to the local-based representation for the texture map of the 3D models. In this paper, we propose a novel 3D face recognition approach based on locally extracted Geodesic Pseudo Zernike Moment Array (GPZMA) of the texture map when only one exemplar per person is available. In the proposed method, the function of the PZM is controlled by the geodesic deformations to tackle the problem of face recognition under the expression and pose variations. The feasibility and effectiveness investigation for the proposed method is conducted through a wide range of experiments using publicly available BU-3DFE and Bosphorus databases including samples with different expression and pose variations. The performance of the proposed method is compared with the performance of three state-of-the-art benchmark approaches. The encouraging experimental results demonstrate that the proposed method achieves much higher accuracy than the benchmarks in single-model databases.
The differential effects of twitch potentiators on charge movements in frog skeletal muscle.

The effects of twitch potentiators at physiologically effective concentrations on intramembrane charge movements were examined in voltage‐clamped frog skeletal muscle in the presence and absence of tetracaine. Caffeine, even at high concentrations (2.5 mM) did not alter the potential dependence of either tetracaine‐sensitive or tetracaine‐resistant portions of non‐linear charge through a voltage range that included the mechanical threshold. Perchlorate (8 mM) altered the form and shifted the potential dependence of the non‐linear charge by about ‐25 mV in the hyperpolarizing direction, but did not alter the total available charge. Comparing charge movements in the presence and absence of 4 mM‐tetracaine demonstrated that perchlorate shifted the threshold and voltage dependence of the delayed ('q gamma') transients but had no action on the steady‐state tetracaine‐resistant charge. Thiocyanate (10 mM) shifted the voltage dependence of charge movements by about 20 mV in the hyperpolarizing direction. Experiments employing 4 mM‐tetracaine demonstrated that this was the result of effects on both tetracaine‐sensitive and tetracaine‐resistant charge movements. On the basis of their effects on contractile activation reported on earlier occasions, these differential effects of twitch potentiators are explicable in terms of tetracaine‐sensitive and tetracaine‐resistant charge components being causally separate and not requiring a direct participation of tetracaine‐resistant charge in contractile activation.
Value of latency measurements to the small palm muscles compared to other conduction parameters in the carpal tunnel syndrome

A variety of electrophysiological studies have been reported to increase the diagnostic sensitivity in the carpal tunnel syndrome (CTS), ’,‘ including latency measurements to the second lumbrical (2~)3,4,12,18 and to the second dorsal interosseous (2DI). We attempted to determine the value of the interlatency difference (ILD) between these over-lying small hand muscles after wrist stimulation of median and ulnar nerves, at equal distances to a single recording R esults were compared with other electrodiagnostic tests. A prelim-inary report has been p~b1ished.l~
Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether

Artemether (AM) is one of the most effective antimalarial drugs. The elimination half-life of AM is very short, and it shows large interindividual variability in pharmacokinetic parameters. The aim of this study was to identify cytochrome P450 (P450) isozymes responsible for the demethylation of AM and to evaluate functional differences between 26 CYP2B6 allelic variants in vitro. Of 14 recombinant P450s examined in this study, CYP2B6 and CYP3A4 were primarily responsible for production of the desmethyl metabolite dihydroartemisinin. The intrinsic clearance (Vmax/Km) of CYP2B6 was 6-fold higher than that of CYP3A4. AM demethylation activity was correlated with CYP2B6 protein levels (P = 0.004); however, it was not correlated with CYP3A4 protein levels (P = 0.27) in human liver microsomes. Wild-type CYP2B6.1 and 25 CYP2B6 allelic variants (CYP2B6.2-CYP2B6.21 and CYP2B6.23-CYP2B6.27) were heterologously expressed in COS-7 cells. In vitro analysis revealed no enzymatic activity in 5 variants (CYP2B6.8, CYP2B6.12, CYP2B6.18, CYP2B6.21, and CYP2B6.24), lower activity in 7 variants (CYP2B6.10, CYP2B6.11, CYP2B6.14, CYP2B6.15, CYP2B6.16, CYP2B6.20, and CYP2B6.27), and higher activity in 4 variants (CYP2B6.2, CYP2B6.4, CYP2B6.6, and CYP2B6.19), compared with that of wild-type CYP2B6.1. In kinetic analysis, 3 variants (CYP2B6.2, CYP2B6.4, and CYP2B6.6) exhibited significantly higher Vmax, and 3 variants (CYP2B6.14, CYP2B6.20 and CYP2B6.27) exhibited significantly lower Vmax compared with that of CYP2B6.1. This functional analysis of CYP2B6 variants could provide useful information for individualization of antimalarial drug therapy.
Fast, recurrent, attentional modulation improves saliency representation and scene recognition

The human brain uses visual attention to facilitate object recognition. Traditional theories and models envision this attentional mechanism either in a pure feedforward fashion for selection of regions of interest or in a top-down task-priming fashion. To these well-known attentional mechanisms, we add here an additional novel one. The approach is inspired by studies of biological vision pertaining to the asynchronous timing of feedforward signals among different early visual areas and the role of recurrent connections from short latency areas to facilitate object recognition [7]. It is suggested that recurrence elicited from these short latency dorsal areas improves the slower feedforward processing in the early ventral areas. We therefore propose a computational model that simulates this process. To test this model, we add such fast recurrent processes to a well-known model of feedforward saliency, AIM [6] and show that those recurrent signals can modulate the output of AIM to improve its utility in recognition by later stages. We further add the proposed model to a back-propagation neural network for the task of scene recognition. Experimental results on standard video sequences show that the discriminating power of the modulated representation is significantly improved, and the implementation consistently outperforms existing work including a benchmark system that does not include recurrent refinement.
Novel mutation in mitochondrial DNA in 2 siblings with Leigh syndrome

Leigh syndrome is clinically and genetically heterogeneous, associated with mutations in mitochondrial and nuclear genes.1 Diagnostic criteria include progressive disorder with motor and intellectual delay/regression; signs and symptoms of brainstem and/or basal ganglia disease; raised lactate concentration in blood and/or CSF; and one or more of the following: (1) characteristic features on neuroimaging (bilateral symmetrical hyperintensities in brainstem, basal ganglia, dentate nuclei, and optic nerves on T2-weighted MRI); (2) typical neuropathologic changes; and (3) typical neuropathology in a similarly affected sibling.2 We describe 2 African American siblings who have a mutation in the mitochondrial MT-TL2 gene and a clinical diagnosis of Leigh syndrome. The same mutation is also identified in their neurologically asymptomatic mother.
Fetal Alcohol Syndrome: Experience With 41 Patients

Forty-one patients with the fetal alcohol syndrome, including 11 whose cases were previously reported, were studied. These children have a pattern of defects including prenatal and postnatal growth deficiency, small head size with mental subnormality, and facial abnormalities allowing for recognition of the disorder in infancy. The same pattern of abnormalities has been independently reported from France in a series of 127 offspring of chronic alcoholics. (JAMA235:1458-1460, 1976)
Crimean-Congo Hemorrhagic Fever among Health Care Workers, Turkey

We investigated 9 cases of Crimean-Congo hemorrhagic fever (1 fatal, 2 asymptomatic) among health care workers in Turkey. Needlestick injuries were reported for 4 workers. Eight received ribavirin. In addition to standard precautions, airborne infection isolation precautions are essential during aerosol-generating procedures. For postexposure prophylaxis and therapy, ribavirin should be given.