Miracle-dz/UniFAR-FTUs huggingface dataset:
The Head and the Heart. National Identity and Urban Planning in a Devolved Scotland

Questions of identity and how it is changing under the influences of globalization and how in turn it is affecting government and policy processes have become increasingly to the fore in recent years. Despite shifts towards devolution in the UK and the anticipation of such processes heralding an opportunity for governance to better reflect national identity, little interest has been paid to the role of planning in such issues. An essential component of identity that has influenced attitudes towards planning is the role of myths. Two myths that have been significant for planning in Scotland are those of egalitarianism and radicalism, both of which have contributed towards the idea of Scottish planning being distinct from and superior to its English counterpart. These two myths form part of what Tom Nairn has termed the 'heart' of Scottish identity founded upon romantic, historic imagery of identity. The 'head' is formed by the realization of the need to compete economically in a globalized free-market. This paper explores how both the head and the heart are driving the future of Scottish planning through the devolved Parliament. It then goes on to address the institutional and political influences through the Scottish Parliament and the likely trajectory for change. It concludes that planning is becoming less a mechanism that reflects national identity and more of a facilitator for economic growth with important symbolic significance of distinctiveness.
Immune recovery of middle-aged HIV patients following antiretroviral therapy

Abstract In HIV-infected persons, age is negatively associated with optimal CD4 recovery following antiretroviral therapy. Our understanding of the situation in older adults, especially the middle-aged is, however, limited. We undertook to examine the latter's pattern of CD4/CD8 recovery following antiretroviral therapy. Retrospective clinical cohort data of HIV patients diagnosed between 1985 and 2014 in Hong Kong were collected. They were categorized by age at treatment initiation, viz., young adults (age 18–49), middle-aged (age 50–64), and elderly (≥65 years’ old). Predictors of immune recovery (CD4 count, CD8 count, CD4/CD8 ratio) over time were examined using multivariable linear generalized estimating equations. A total of 2754 patients (aged ≥18) have been on antiretroviral therapy, with baseline characteristics similar between middle-aged and the elderly. Late diagnosis, defined as progression to AIDS within 3 months of HIV diagnosis, was less common in middle-aged (odds ratio = 0.58, 95% confidence interval = 0.37–0.91). Among Chinese patients who have been on treatment for ≥4 years (n = 913), 80.6%, 14.6%, and 4.8% were young adults, middle-aged, and elderly respectively. Late treatment initiation, defined as AIDS diagnosis or CD4 count ⩽100 cells/&mgr;L before treatment, was common in middle-aged and elderly, the former however had faster CD4 recovery (3.95 vs. 3.36 cells/&mgr;L/month), but slower CD8 decline (−1.76 vs. −4.34 cells/&mgr;L/month) and CD4/CD8 normalization (0.009 vs. 0.0101/month). As a transitional age group, the immune recovery of middle-aged patients lagged behind young adults largely because of late treatment initiation. Following adoption of early and non-CD4-guided treatment initiation, their long-term clinical outcome is expected to improve.
The role of dopamine D4 receptor in the induction of behavioral sensitization to amphetamine and accompanying biochemical and molecular adaptations.

Our studies examined the role of dopamine D4 receptors in the induction of behavioral sensitization to amphetamine (Amp) and accompanying neurochemical and molecular adaptive responses using a highly selective D4 antagonist, PNU-101387G. Behavioral sensitization to an acute challenge of Amp (2 mg/kg, s.c.) was observed in rats pretreated with five daily doses of Amp (2 mg/kg/d, s.c.) followed by 7-day withdrawal. Interestingly, coadministration of PNU-101387G with Amp during pretreatment completely blocked the sensitized response to an acute Amp challenge. The behavioral sensitization and its blockade by the D4 antagonist were observed in the absence of significant differences in cerebellar Amp levels among the various pretreatment groups. Accompanying behavioral sensitization were two postsynaptic neuroadaptive responses: reduction in the ability of Amp to induce c-fos gene expression in the infralimbic/ventral prelimbic cortex and NT/N mRNA in the accumbal shell. However, concurrent blockade of D4 receptors during Amp pretreatment prevented the refractoriness in c-fos and NT/N responsiveness to acute Amp. We observed also a presynaptic neuroplastic response associated with the behavioral sensitization: a significant augmentation in the ability of Amp to increase extracellular dopamine concentrations in the nucleus accumbens shell. As with the behavioral sensitization and associated postsynaptic adaptive responses, concurrent administration of PNU-101387G with Amp during pretreatment blocked the augmentation in Amp-induced dopamine release. Taken together, these data demonstrate that dopamine D4 receptors play an important role in the induction of behavioral sensitization to Amp and accompanying adaptations in pre- and postsynaptic neural systems associated with the mesolimbocortical dopamine projections.
Factor-Reduced Human Induced Pluripotent Stem Cells Efficiently Differentiate into Neurons Independent of the Number of Reprogramming Factors

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of the transcription factors OCT4, SOX2, KLF4, and c-Myc holds great promise for the development of personalized cell replacement therapies. In an attempt to minimize the risk of chromosomal disruption and to simplify reprogramming, several studies demonstrated that a reduced set of reprogramming factors is sufficient to generate iPSC. We recently showed that a reduction of reprogramming factors in murine cells not only reduces reprogramming efficiency but also may worsen subsequent differentiation. To prove whether this is also true for human cells, we compared the efficiency of neuronal differentiation of iPSC generated from fetal human neural stem cells with either one (OCT4; hiPSC1F-NSC) or two (OCT4, KLF4; hiPSC2F-NSC) reprogramming factors with iPSC produced from human fibroblasts using three (hiPSC3F-FIB) or four reprogramming factors (hiPSC4F-FIB). After four weeks of coculture with PA6 stromal cells, neuronal differentiation of hiPSC1F-NSC and hiPSC2F-NSC was as efficient as iPSC3F-FIB or iPSC4F-FIB. We conclude that a reduction of reprogramming factors in human cells does reduce reprogramming efficiency but does not alter subsequent differentiation into neural lineages. This is of importance for the development of future application of iPSC in cell replacement therapies.
Cabozantinib (XL184) Inhibits Growth and Invasion of Preclinical TNBC Models

Purpose: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that is associated with poor clinical outcome. There is a vital need for effective targeted therapeutics for TNBC patients, yet treatment strategies are challenged by the significant intertumoral heterogeneity within the TNBC subtype and its surrounding microenvironment. Receptor tyrosine kinases (RTK) are highly expressed in several TNBC subtypes and are promising therapeutic targets. In this study, we targeted the MET receptor, which is highly expressed across several TNBC subtypes. Experimental Design: Using the small-molecule inhibitor cabozantinib (XL184), we examined the efficacy of MET inhibition in preclinical models that recapitulate human TNBC and its microenvironment. To analyze the dynamic interactions between TNBC cells and fibroblasts over time, we utilized a 3D model referred to as MAME (Mammary Architecture and Microenvironment Engineering) with quantitative image analysis. To investigate cabozantinib inhibition in vivo, we used a novel xenograft model that expresses human HGF and supports paracrine MET signaling. Results: XL184 treatment of MAME cultures of MDA-MB-231 and HCC70 cells (± HGF-expressing fibroblasts) was cytotoxic and significantly reduced multicellular invasive outgrowths, even in cultures with HGF-expressing fibroblasts. Treatment with XL184 had no significant effects on METneg breast cancer cell growth. In vivo assays demonstrated that cabozantinib treatment significantly inhibited TNBC growth and metastasis. Conclusions: Using preclinical TNBC models that recapitulate the breast tumor microenvironment, we demonstrate that cabozantinib inhibition is an effective therapeutic strategy in several TNBC subtypes. Clin Cancer Res; 22(4); 923–34. ©2015 AACR.
Accuracy of Social Perception: An Integration and Review of Meta-Analyses

This review examines the overall accuracy of social perception across several research topics and identifies factors that inf luence the accuracy of social perception. Findings from 14 meta-analyses examining topics such as social/personality judgments, health judgments, legal judgments, and academic/vocational judg-ments were obtained. Social perception accuracy was generally moderate, yielding an average effect size (r) of . 32. However, individual meta-analytic effects varied widely, with some topics yielding small effects (e.g., lie detection, eyewitness identification) and other topics yielding large effects (e.g., educational judgments, health judgments). Several moderators of social perception accuracy were identified, includ-ing the nature of the information source, familiarity of the target, type of personality trait, and severity of the outcome being judged. These findings provide a comprehensive summary and novel integration of disparate findings on the accuracy of social perception. Concluding remarks highlight avenues for future research and call for cross-disciplinary collaborations that would enhance our understanding of social perception.
The Gaia-ESO Survey: the analysis of high-resolution UVES spectra of FGK-type stars

Context. The ongoing Gaia-ESO Public Spectroscopic Survey is using FLAMES at the VLT to obtain high-quality medium-resolution Giraffe spectra for about 10(5) stars and high-resolution UVES spectra for about 5000 stars. With UVES, the Survey has already observed 1447 FGK-type stars. Aims. These UVES spectra are analyzed in parallel by several state-of-the-art methodologies. Our aim is to present how these analyses were implemented, to discuss their results, and to describe how a final recommended parameter scale is defined. We also discuss the precision (method-to-method dispersion) and accuracy (biases with respect to the reference values) of the final parameters. These results are part of the Gaia-ESO second internal release and will be part of its first public release of advanced data products. Methods. The final parameter scale is tied to the scale defined by the Gaia benchmark stars, a set of stars with fundamental atmospheric parameters. In addition, a set of open and globular clusters is used to evaluate the physical soundness of the results. Each of the implemented methodologies is judged against the benchmark stars to define weights in three different regions of the parameter space. The final recommended results are the weighted medians of those from the individual methods. Results. The recommended results successfully reproduce the atmospheric parameters of the benchmark stars and the expected T-eff-log g relation of the calibrating clusters. Atmospheric parameters and abundances have been determined for 1301 FGK-type stars observed with UVES. The median of the method-to-method dispersion of the atmospheric parameters is 55K for T-eff, 0.13dex for log g and 0.07 dex for [Fe/H]. Systematic biases are estimated to be between 50-100 K for T-eff, 0.10-0.25 dex for log g and 0.05-0.10 dex for [Fe/H]. Abundances for 24 elements were derived: C, N, O, Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Y, Zr, Mo, Ba, Nd, and Eu. The typical method-to-method dispersion of the abundances varies between 0.10 and 0.20 dex. Conclusions. The Gaia-ESO sample of high-resolution spectra of FGK-type stars will be among the largest of its kind analyzed in a homogeneous way. The extensive list of elemental abundances derived in these stars will enable significant advances in the areas of stellar evolution and Milky Way formation and evolution.
Incorporation of an Active Site Inhibitor in Factor VIIa Alters the Affinity for Tissue Factor*

Recent studies showed that the administration of active site-inhibited factor VIIa blocked factor VIIa/tissue factor-induced fibrin and thrombus formation in ex vivo andin vivo model systems. These studies suggest that inactivated factor VIIa competes efficiently with plasma factor VII(a) for a limited number of tissue factor sites. In the present study, we compared the interactions of factor VIIa and active site-inhibited factor VIIa with tissue factor. Competition studies of factor VIIa and active site-inhibited factor VIIa in a factor X activation assay showed that the affinity of the latter for relipidated tissue factor was 5-fold higher than that of factor VIIa. Radioligand binding studies with a human bladder carcinoma cell line (J82) and surface plasmon resonance studies using soluble tissue factor demonstrated a faster association and a slower dissociation for the active site-inhibited factor VIIa. Studies of equilibrium binding to cell surface tissue factor showed that the affinity of active site-inhibited VIIa was 5-fold higher than that of factor VIIa to non-functional tissue factor sites, whereas both inactivated factor VIIa and factor VIIa bound to functional tissue factor sites with the same high affinity. Comparison of the CD spectra of factor VIIa and active site-inactivated factor VIIa revealed structural differences in the protease domain. The potential physiological implications of these findings are discussed.
Enrichment of Foxp3+ CD4 Regulatory T Cells in Migrated T Cells to IL-6– and IL-8–Expressing Tumors through Predominant Induction of CXCR1 by IL-6

Analysis of cytokine and chemokine production by tumor cell lines including five lung cancers, a malignant mesothelioma, and a malignant melanoma recently established in our laboratory showed rather high production of IL-8 in all tumors and IL-6 in one lung cancer, the malignant mesothelioma, and the malignant melanoma. We investigated the migration of PBMCs to these tumor cells using Transwell plates and showed enrichment of Foxp3+ CD4 regulatory T cells (Tregs) in migrated T cells to both IL-6– and IL-8–producing tumors. Marked induction of CXCR1 expression on Foxp3+ CD4 Tregs by IL-6 followed by IL-8–mediated migration appeared to be responsible for enriched migration. Frequent production of IL-8 by the tumors and Treg migration to those tumors through induction of IL-8R expression by IL-6 is one of the mechanisms for tumor escape.
Followers' characteristics as predictors of their preference for servant leadership: A followership approach

OF THE THESIS Followers‟ Characteristics as Predictors of their Preference for Servant Leadership: A Followership Approach by Elisa Maria Torres Master of Science in Psychology with a Concentration in Applied Psychology San Diego State University, 2014 Until recently, the vast majority of leadership research has been leader-focused, examining leader characteristics and behaviors that make for effective leadership. A more recent shift towards followership “reverses the lens” by focusing on how followers‟ perceptions of their role in the leadership process affects the leaders‟ effectiveness. Servant leadership is a follower-focused leadership style in which the leader‟s main goal is to selflessly serve followers‟ needs first and foremost. This study examined the relationships between five personal characteristics and preference for servant leadership, and the mediating effect of followers‟ implicit leadership theories (ILTs) and implicit followership theories (IFTs) on those relationships. Participants included undergraduate and graduate students who participated as part of an extra credit class assignment. Data were gathered in three phases, each of which were two weeks apart, with the personality characteristic variables being collected in phase 1, the implicit leadership and followership theories at phase 2, and the dependent variable, preference for servant leadership, collected at phase 3. After conducting a factor analysis to evaluate the co-production of leadership scale developed for this thesis, multiple regression analyses were conducted to test hypotheses concerning direct predictors of servant leader preference, and bootstrap analyses were used to test the mediation hypotheses. Additional exploratory analyses included data on the dichotomous choice of the servant leader versus the other leadership styles presented. The results of this study showed limited support that personal characteristics and values are useful in predicting servant leadership preference. Nevertheless, some insights were gained regarding personal characteristics that predicted preference for servant leadership, particularly with regard to proactive personality. In addition, the findings clarified the relationship between co-production of leadership beliefs (IFTs) and prototypical ILTs and anti-prototypical ILTs. Followers who held strong co-production of leadership beliefs also held prototypical ILTs. Conversely, those who held weaker co-production of leadership beliefs held anti-prototypical ILTs. Results suggest that although the characteristics examined in this study were not strong predictors of preference for servant leadership, some characteristics are important and should be examined further. Additional research in this area will expand our understanding of how follower characteristics and context impact preference for a leadership style, allowing for a more holistic understanding of the leadership process.
Creative, Personal and Social Engagement in the Later Years: Realisation Through Leisure

The social, psychological and philosophical issues bearing on the creative, personal and social engagement of older people with intellectual disabilities (mental handicap) are examined. Specifically, the relevance of Lasleu’s concept of the Third Age, Nash’s analysis of the nature of leisure in the second half of the Twentieth Century and Goode’s formulation of Quality of Life concepts for people with disabilities are related to develop an overall view of leisure provision for older people in this population. The implications of such a view for models of service provision are considered with special reference to choice and flexibility of leisure context.
Final Report of a National Study on Diversity in Journalism and Mass Communication Education, Phase II

This study explored the effectiveness of the Accrediting Council on Education in Journalism and Mass Communications' diversity standard from 1989 to 2002. Although this standard, known as Standard 12, had the most non-compliances, the findings credit the standard for increasing non-white and female faculty and students in accredited journalism units. The findings also credit the standard for the development of courses that focus on issues pertaining to women and non-whites in journalism. But the study also concluded that stronger enforcement and additional strategies were needed to fully achieve diversity in journalism and mass communication education.
Nurse safety: How is safety climate related to affect and attitude?

ABSTRACT Occupational accidents and injuries continue to be a critical concern for nurses, given the hazardous healthcare environment. This study advances the research on workplace safety by studying the process variables (i.e. job-related negative affect (JRNA) and job satisfaction) in explaining the relationship between safety climate and various safety criteria in nurses. Based on survey data from 326 nurses, our findings suggest that psychological safety climate is negatively related to JRNA, turnover intentions, safety workarounds, and workplace hazards. In addition, structural equation modelling indicated general support for a model in which psychological safety climate influences employee strain through job attitudes, including JRNA and job satisfaction. More specifically, job attitudes were found to mediate the relationship between psychological safety climate and turnover intentions, experience of hazards, and injuries. Safety workarounds did not significantly relate to injuries. The present study contributes to the ongoing improvement of interventions aimed at mitigating nurses’ injuries by integrating job attitudes into the safety climate–safety outcome framework.
A Methodology for Extrinsic Evaluation of Text Summarization: Does ROUGE Correlate?

This paper demonstrates the usefulness of summaries in an extrinsic task of relevance judgment based on a new method for measuring agreement, Relevance-Prediction, which compares subjects’ judgments on summaries with their own judgments on full text documents. We demonstrate that, because this measure is more reliable than previous gold-standard measures, we are able to make stronger statistical statements about the benefits of summarization. We found positive correlations between ROUGE scores and two different summary types, where only weak or negative correlations were found using other agreement measures. However, we show that ROUGE may be sensitive to the choice of summarization style. We discuss the importance of these results and the implications for future summarization evaluations.
Spatial Distribution of Podoconiosis in Relation to Environmental Factors in Ethiopia: A Historical Review

Background An up-to-date and reliable map of podoconiosis is needed to design geographically targeted and cost-effective intervention in Ethiopia. Identifying the ecological correlates of the distribution of podoconiosis is the first step for distribution and risk maps. The objective of this study was to investigate the spatial distribution and ecological correlates of podoconiosis using historical and contemporary survey data. Methods Data on the observed prevalence of podoconiosis were abstracted from published and unpublished literature into a standardized database, according to strict inclusion and exclusion criteria. In total, 10 studies conducted between 1969 and 2012 were included, and data were available for 401,674 individuals older than 15 years of age from 229 locations. A range of high resolution environmental factors were investigated to determine their association with podoconiosis prevalence, using logistic regression. Results The prevalence of podoconiosis in Ethiopia was estimated at 3.4% (95% CI 3.3%–3.4%) with marked regional variation. We identified significant associations between mean annual Land Surface Temperature (LST), mean annual precipitation, topography of the land and fine soil texture and high prevalence of podoconiosis. The derived maps indicate both widespread occurrence of podoconiosis and a marked variability in prevalence of podoconiosis, with prevalence typically highest at altitudes >1500 m above sea level (masl), with >1500 mm annual rainfall and mean annual LST of 19–21°C. No (or very little) podoconiosis occurred at altitudes <1225 masl, with annual rainfall <900 mm, and mean annual LST of >24°C. Conclusion Podoconiosis remains a public health problem in Ethiopia over considerable areas of the country, but exhibits marked geographical variation associated in part with key environmental factors. This is work in progress and the results presented here will be refined in future work.