Miracle-dz/UniFAR-FTUs huggingface dataset:
Dietary Diversity and Nutritional Adequacy among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Dietary guidelines emphasize the importance of a varied diet to provide an adequate nutrient intake. However, an older age is often associated with consumption of monotonous diets that can be nutritionally inadequate, increasing the risk for the development or progression of diet-related chronic diseases, such as metabolic syndrome (MetS). To assess the association between dietary diversity (DD) and nutrient intake adequacy and to identify demographic variables associated with DD, we cross-sectionally analyzed baseline data from the PREDIMED-Plus trial: 6587 Spanish adults aged 55–75 years, with overweight/obesity who also had MetS. An energy-adjusted dietary diversity score (DDS) was calculated using a 143-item validated semi-quantitative food frequency questionnaire (FFQ). Nutrient inadequacy was defined as an intake below 2/3 of the dietary reference intake (DRI) forat least four of 17 nutrients proposed by the Institute of Medicine (IOM). Logistic regression models were used to evaluate the association between DDS and the risk of nutritionally inadequate intakes. In the higher DDS quartile there were more women and less current smokers. Compared with subjects in the highest DDS quartile, those in the lowest DDS quartile had a higher risk of inadequate nutrient intake: odds ratio (OR) = 28.56 (95% confidence interval (CI) 20.80–39.21). When we estimated food varietyfor each of the food groups, participants in the lowest quartile had a higher risk of inadequate nutrient intake for the groups of vegetables, OR = 14.03 (95% CI 10.55–18.65), fruits OR = 11.62 (95% CI 6.81–19.81), dairy products OR = 6.54 (95% CI 4.64–9.22) and protein foods OR = 6.60 (95% CI 1.96–22.24). As DDS decreased, the risk of inadequate nutrients intake rose. Given the impact of nutrient intake adequacy on the prevention of non-communicable diseases, health policies should focus on the promotion of a healthy varied diet, specifically promoting the intake of vegetables and fruit among population groups with lower DDS such as men, smokers or widow(er)s.
A gonad-expressed opsin mediates light-induced spawning in the jellyfish Clytia

Across the animal kingdom, environmental light cues are widely involved in regulating gamete release, but the molecular and cellular bases of the photoresponsive mechanisms are poorly understood. In hydrozoan jellyfish, spawning is triggered by dark-light or light-dark transitions acting on the gonad, and is mediated by oocyte maturation-inducing neuropeptide hormones (MIHs) released from the ectoderm. We determined in Clytia hemisphaerica that blue-cyan light triggers spawning in isolated gonads. A candidate opsin (Opsin9) was found co-expressed with MIH within specialised ectodermal cells. Opsin9 knockout jellyfish generated by CRISPR/Cas9 failed to undergo oocyte maturation and spawning, a phenotype reversible by synthetic MIH. Gamete maturation and release in Clytia is thus regulated by gonadal photosensory-neurosecretory cells that secrete MIH in response to light via Opsin9. Similar cells in ancestral eumetazoans may have allowed tissue-level photo-regulation of diverse behaviours, a feature elaborated in cnidarians in parallel with expansion of the opsin gene family.
Diagnosis of mesenteric panniculitis in the multi-detector computed tomography era

Objectives: To assess the prevalence and associations of mesenteric panniculitis (MP) using multi-detector CT (MDCT). Methods: This retrospective study included 4758 consecutive patients who underwent abdomino-pelvic MDCT between January 2012 and December 2014 at Jordan University Hospital, Amman, Jordan. Radiological database was searched for MP diagnosis and patients with suspected MP were re-evaluated by an experienced radiologist to confirm the diagnosis. Data on all patients with confirmed MP diagnosis were subsequently collected and analyzed. Results: Computed tomography features of MP were identified in 90 patients (41 males, 49 females), a prevalence of 1.9%. Mesenteric panniculitis was identified in both asymptomatic and symptomatic patients. Malignancy was found in 28 MP patients (31%) and 44 of the MP patients (49%) had prior history of abdomino-pelvic surgery. Mesenteric panniculitis was significantly more frequently associated with prior abdomino-pelvic surgery (p=0.0001) and the likelihood of associated malignancy in patients with MP was 2.1-fold higher than in patients without MP (p=0.0013). Conclusion: Mesenteric panniculitis can be reliably diagnosed by MDCT due to its typical CT appearance. Its identification is important because of its significant association with malignancy and because it represents one of the differential diagnoses in patients with nonspecific symptoms referred for abdomino-pelvic CT.
Patterns of Transcriptome Divergence in the Male Accessory Gland of Two Closely 1 Related Species of Field Crickets. 2 3 4

1 related species of field crickets. 2 3 4 ANDRÉS, J.A. , LARSON, E.L. , BOGDANOWICZ, S.M. , AND HARRISON, R.G. 5 Department of Biology, University of Saskatchewan, Saskatoon, S.K. , Canada 6 Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, N.Y. , USA 7 8 Running Title: Transcriptome differentiation 9 10
Evaluation of Hydrogels Based on Poloxamer 407 and Polyacrylic Acids for Enhanced Topical Activity of Gentamicin against Susceptible Infections

Purpose: To formulate hydrogels based on poloxamer 407 and polyacrylic acids (Carbopols® 971P and 974P), and evaluate its suitability for enhanced topical delivery of gentamicin, a potent but highly toxic aminoglycoside antibiotic. Methods: Topical hydrogels of gentamicin were produced using poloxamer 407 and polyacrlic acids (Carbopols® 971P and 974P), and evaluated in terms of drug content, pH, physical assessment, viscosity and stability. In vitro antimicrobial drug release was conducted using four microorganisms ‐ Escherichia coli, Salmonella typhi, Staphylococcus aureus and Pseudomonas aeruginosa. Results: Stable gentamicin-loaded hydrogels with good encapsulation efficiency (maximum EE% of 85.76 to 90.66 %) as well as greater zones of inhibition against all organisms (maximum range: 22.34 ± 2.35 to 29.40 ± 3.07 mm) than commercially available gentamicin ointment and pure sample of gentamicin (p < 0.05), were produced. Overall, poloxamer 407 hydrogels of gentamicin gave the most desirable properties in terms of pH, viscosity and rapid concentration and time-dependent antibacterial activity on all tested micro-organisms, superior to polyacrylic acids hydrogels of gentamicin. Conclusion: This study demonstrates that poloxamer 407 hydrogels of gentamicin may offer a promising approach for topical delivery of gentamicin for the treatment of skin infections caused by gentamicin-susceptible bacteria.
Knowledge and Information Systems Class Separation through Variance : A new Application of Outlier Detection

This paper introduces a new outlier detection approach and discusses and extends a new concept, class separation through variance. We show that even for balanced and concentric classes differing only in variance, accumulating information about the outlierness of points in multiple subspaces leads to a ranking in which the classes naturally tend to separate. Exploiting this leads to a highly effective and efficient unsupervised class separation approach. Unlike typical outlier detection algorithms, this method can be applied beyond the ‘rare classes’ case with great success. The new algorithm FASTOUT introduces a number of novel features. It employs sampling of subspaces points and is highly efficient. It handles arbitrarily sized subspaces and converges to an optimal subspace size through the use of an objective function. In addition, two approaches are presented for automatically deriving the class of the data points from the ranking. Experiments show that FASTOUT typically outperforms other state-of-the-art outlier detection methods on high dimensional data such as Feature Bagging, SOE1, LOF, ORCA and Robust Mahalanobis Distance, and competes even with the leading supervised classification methods for separating classes.
Calcareous Lesions of the Distal Extremities Resembling Tumoral Calcinosis (Tumoral Calcinosislike Lesions): Clinicopathologic Study of 43 Cases Emphasizing a Pathogenesis-based Approach to Classification

Herein, we analyze the clinicopathologic features of 46 distal extremity lesions that have histologic features similar to conventional tumoral calcinosis (tumoral calcinosislike; TC-L). The study included 31 females and 12 males (whites:non-whites>3:1) ranging in age from 1 to 91 (mean, 39; median, 42) years. The lesions presented in fingers (n=20), feet (n=10), wrist (n=6), hands (5), toes (n=4), and ankle (n=1) were solitary in all but 5 patients and ranged in size from 0.3 to 4.5 (mean, 1.6; median, 1.4) cm. Chief initial complaints included presence of a painful (n=16) or asymptomatic (n=7) mass, and limitation of joint mobility (n=3). Pertinent clinical associations included antecedent trauma (n=7), scleroderma (n=3), long-standing osteoarthritis (n=3), bony deformities (n=5), including 2 infants with congenital hand malformations, and chronic renal failure (n=2). Patients were stratified into one of the 3 recognized clinical settings of TC: primary normophosphatemic (n=17), secondary (n=5), or primary hyperphosphatemic TC (n=1). The 20 remaining patients were placed in an “indeterminate TC” category. Most lesions were located in tenosynovial/fascial tissue, but 13 lesions involved dermis and 1 was intra-articular. Histologically, the process consisted of multiple cystic or cleftlike spaces bordered by histiocytes, osteoclastlike giant cells, and a variable inflammatory infiltrate and containing fibrin, granular calcific debris, and calcospherites. Pools of calcific debris bordered by sclerotic collagen and a sparse cellular element predominated in 4 cases. Cartilaginous metaplasia was identified in 10 lesions and evidence of hemorrhage or specific injury was observed in 12 examples. Follow-up data for 22 patients (interval range, 1 to 30 y; median, 6 y) revealed 17 individuals with no evidence of recurrent disease or the development of additional lesions after simple (local) excision. One patient (indeterminate TC) required reexcision of a thumb mass 1 year after surgery. All 3 scleroderma patients developed additional TC-L lesions. Acral TC-L lesions are histologically similar to conventional TC, but present as smaller size lesions. Most TC-L lesions are closely aligned with primary normophosphatemic or secondary TC. Acral TC-L lesions may be the first manifestation of scleroderma, where the process has the potential to follow an unrelenting course.
[Study of drug poisoning on 2612 cases in the department of emergency].

OBJECTIVE To analyze the characteristics of the drug poisoning. METHODS In the 25 department of emergency selected hospitals, design questionnaires to register the drug poisoning patients who seeking emergency treatment within one-year period. RESULTS Collected 2 612 cases of drug poisoning patients, accounted as 0.31% of the aggregated number of emergency patients at the same time, as well as 23.42% of poisoning patients at the same time. The sexual proportion between males and females was 1:3.45, average age was 30.33 years, and the age groups between 15-34 years were the high potentials. The three top ranking industries were farmers, unemployed ones and services. Amongst the samples, 99.12% of them were exposed by mouth transmission. 84.57% were committed as suicides. The medicines most frequently adopted were 1. antianxity drugs; 2. analgesics antipyretic and antirheumatic drugs; 3. antipsychotropic drugs. Only 1.68% of the drug poisoning patients were diagnosed through blood-medicine. CONCLUSION It is recommended to enhance the administration and education of medicines. To establish monitoring system for drug intoxication and improve the quality of diagnose and treatment of drug poisoning patients.
Propylthiouracil-associated antineutrophil cytoplasmic autoantibody-positive vasculitis: retrospective study of 19 cases.

OBJECTIVE To investigate the features, followup data, and outcomes of patients with propylthiouracil (PTU)-associated antineutrophil cytoplasmic autoantibody (ANCA)-positive vasculitis. METHODS Nineteen patients with PTU-associated ANCA-positive vasculitis diagnosed in our hospital from 2000 to 2006 were analyzed retrospectively. RESULTS Our data showed a female predominance among the patients. Eleven patients had involvement of more than one organ. Renal involvement was the most common manifestation. Fourteen patients underwent renal biopsy. Four patients had focal proliferative glomerulonephritis with crescent formation. Two had necrotizing glomerulonephritis with crescent formation. Two patients had minor glomerular abnormalities, 2 had IgA nephropathy, one had membranous nephropathy, one had focal proliferative glomerulonephritis, one had granulomatous interstitial nephritis, and the remaining one had focal segmental glomerular sclerosis. Immune complex glomerulonephritis was found in 3 patients. On indirect immunofluorescence, 17 patients were perinuclear-pattern ANCA-positive, one was positive for atypical ANCA, and one was positive for cytoplasmic-pattern-ANCA. By ELISA, 4 patients were positive for both myeloperoxidase (MPO)-ANCA and proteinase-3 (PR3)-ANCA, one was positive for PR3-ANCA only, and the others were positive for MPO-ANCA only. For the treatment of vasculitis, 5 patients received prednisone alone, 10 received prednisone and cyclophosphamide, and the remaining 4 did not receive prednisone or cyclophosphamide. During followup, 15 patients achieved remission, 3 patients died, and one patient depended on dialysis. In general, MPO-ANCA concentration did not correlate with disease progression, and a delayed decrease of MPO-ANCA concentration was found in most patients who achieved remission. CONCLUSION Most patients with PTU-associated ANCA-positive vasculitis had good outcomes; however, severe cases existed. We suggest early recognition and adequate treatment are necessary to improve outcome.
A temperature, supply voltage compensated floating-gate MOS dosimeter using V/sub TH/ extractor

A temperature and supply voltage compensated floating-gate MOSFET dosimeter is presented. The dosimeter consists of two pairs of floating-gate sensor transistors with identical geometry for compensation purpose, V/sub TH/ (threshold voltage) extractor circuits and substractors. The dosimeter output presents the threshold voltage changes of the floating-gate MOSFET sensors before and after radiation. The circuit has been modeled and simulated in Hspice using TSMC 0.35/spl mu/m CMOS technology at 2.4V power supply. Simulated results show a low sensitivity to temperature and V/sub DD/ variations and a low power consumption of 0.44mW.
A further step towards vascular reparative therapy.

This editorial refers to ‘Endothelial-dependent vasomotion in a coronary segment treated by the ABSORB everolimus-eluting bioresorbable vascular scaffold system is related to plaque composition at the time of bioresorption of the polymer: indirect finding of vascular reparative therapy? ’, by S. Brugaletta et al., doi:10.1093/eurheartj/ehr466 Polymer-based drug-eluting stents (DES) have become the treatment of choice for most patients undergoing percutaneous coronary intervention (PCI). Although these stents efficiently reduce rates of restenosis and the need for vascular reintervention by 70% compared with bare metal stents (BMS), several risks closely related to the metallic cage and polymers have recently been reported. In addition, marked differences exist between various drug–polymer–device combinations that may translate into different biological responses. Different vascular healing responses to the stents could potentially explain differences in net clinical benefit. Poor endothelialization and coverage of the stent struts, fibrin deposition, and local inflammatory or hypersensitivity reactions at the site of DES implantation have been associated with increased risk of stent thrombosis.1,2 Recent studies indicated evidence for device-specific responses in the interference of DES with endothelial function.3–5 The study of Brugaletta et al. 6 brings new hope in cardiology, taking a new step towards vascular reparative therapy. This study suggests that in the near future we might be able to treat coronary lesions using absorbable drug-eluting scaffolds that will provide adequate radial strength to overcome the problem of vascular recoil and will fix local dissection occurring after lesion dilatation. In addition, they will inhibit smooth muscle cell proliferation and will finally allow complete …
Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging

Background Chronic antigenic stimulation by cytomegalovirus (CMV) is thought to increase “immunosenesence” of aging, characterized by accumulation of terminally differentiated CD28- CD8+ T cells and increased CD57, a marker of proliferative history. Whether chronic HIV infection causes similar effects is currently unclear. Methods We compared markers of CD8+ T cell differentiation (e.g., CD28, CD27, CCR7, CD45RA) and CD57 expression on CD28- CD8+ T cells in healthy HIV-uninfected adults with and without CMV infection and in both untreated and antiretroviral therapy (ART)-suppressed HIV-infected adults with asymptomatic CMV infection. Results Compared to HIV-uninfected adults without CMV (n = 12), those with asymptomatic CMV infection (n = 31) had a higher proportion of CD28-CD8+ T cells expressing CD57 (P = 0.005). Older age was also associated with greater proportions of CD28-CD8+ T cells expressing CD57 (rho: 0.47, P = 0.007). In contrast, untreated HIV-infected CMV+ participants (n = 55) had much lower proportions of CD28- CD8+ cells expressing CD57 than HIV-uninfected CMV+ participants (P<0.0001) and were enriched for less well-differentiated CD28- transitional memory (TTR) CD8+ T cells (P<0.0001). Chronically HIV-infected adults maintaining ART-mediated viral suppression (n = 96) had higher proportions of CD28-CD8+ T cells expressing CD57 than untreated patients (P<0.0001), but continued to have significantly lower levels than HIV-uninfected controls (P = 0.001). Among 45 HIV-infected individuals initiating their first ART regimen, the proportion of CD28-CD8+ T cells expressing CD57 declined (P<0.0001), which correlated with a decline in percent of transitional memory CD8+ T cells, and appeared to be largely explained by a decline in CD28-CD57- CD8+ T cell counts rather than an expansion of CD28-CD57+ CD8+ T cell counts. Conclusions Unlike CMV and aging, which are associated with terminal differentiation and proliferation of effector memory CD8+ T cells, HIV inhibits this process, expanding less well-differentiated CD28- CD8+ T cells and decreasing the proportion of CD28- CD8+ T cells that express CD57.
DNA Methylation May Restrict but Does Not Determine Differential Gene Expression at the Sgy/Tead2 Locus during Mouse Development

ABSTRACT Soggy (Sgy) and Tead2, two closely linked genes with CpG islands, were coordinately expressed in mouse preimplantation embryos and embryonic stem (ES) cells but were differentially expressed in differentiated cells. Analysis of established cell lines revealed that Sgy gene expression could be fully repressed by methylation of the Sgy promoter and that DNA methylation acted synergistically with chromatin deacetylation. Differential gene expression correlated with differential DNA methylation, resulting in sharp transitions from methylated to unmethylated DNA at the open promoter in both normal cells and tissues, as well as in established cell lines. However, neither promoter was methylated in normal cells and tissues even when its transcripts were undetectable. Moreover, the Sgy promoter remained unmethylated as Sgy expression was repressed during ES cell differentiation. Therefore, DNA methylation was not the primary determinant of Sgy/Tead2 expression. Nevertheless, Sgy expression was consistently restricted to basal levels whenever downstream regulatory sequences were methylated, suggesting that DNA methylation restricts but does not regulate differential gene expression during mouse development.
Lurasidone for the treatment of depressive symptoms in schizophrenia: analysis of 4 pooled, 6-week, placebo-controlled studies

Objective Depressive symptoms are common in schizophrenia and can worsen outcomes and increase suicide risk. Lurasidone is an atypical antipsychotic agent indicated for the treatment of schizophrenia and for the treatment of major depressive episodes associated with bipolar I disorder. This post hoc analysis evaluated the effect of lurasidone on depressive symptoms in patients with schizophrenia. Methods Patient-level data were pooled from 4 similarly designed, double-blind, placebo-controlled, 6-week registration studies of lurasidone (40–160 mg/d) in adult patients with an acute exacerbation of schizophrenia. Changes in depressive symptoms, measured by the Montgomery–Åsberg Depression Rating Scale (MADRS), were analyzed for the overall sample and for subgroups of patients stratified by baseline MADRS scores. Results MADRS assessments at baseline and endpoint (day 42 or last observation carried forward [LOCF]) were available for 1330 patients. Patients receiving lurasidone experienced significantly greater decreases in MADRS score (–2.8, least-squares [LS] mean change, LOCF) compared with patients receiving placebo (–1.4, P < .001, effect size 0.24). Analysis of change in MADRS score (LOCF) by baseline symptom severity (MADRS score of ≥12, ≥14, ≥16, ≥18) showed significantly greater improvement for lurasidone-treated patients across all severity groups; effect sizes ranged from 0.25 to 0.34. Among patients with a baseline MADRS score of ≥12, depressive symptom remission (defined as MADRS score <10 at LOCF endpoint) was attained by 45.0% of lurasidone-treated patients and 36.3% of patients receiving placebo (P < .05). Conclusions In a pooled analysis of short-term, placebo-controlled studies, lurasidone significantly improved depressive symptoms in patients with schizophrenia.
A Controlled Interactive Multiple Model Filter for Combined Pedestrian Intention Recognition and Path Prediction

We present a novel approach combining pedestrian intention recognition and path prediction for advanced video-based driver assistance systems. The core algorithm uses an Interacting Multiple Model Filter in combination with a Latent-dynamic Conditional Random Field model. The model integrates pedestrian dynamics and situational awareness using observations from a stereo-video system for pedestrian detection and human head pose estimation. Evaluation of our method is performed on a public available dataset addressing scenarios of lateral approaching pedestrians that might cross the road, turn into the road or stop at the curbside. During experiments, we demonstrate that the proposed approach leads to better path prediction performance in terms of a smaller lateral position error compared to state-of-the-art pedestrian intention recognition and path prediction approaches. The computational costs of our approach is comparatively low and therefore can be ported easily onto a real-time system.