Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and Standardization of the Self-Regulation Skills Interview (SRSI): A New Clinical Assessment Tool for Acquired Brain Injury

The Self-regulation Skills Interview (SRSI) is a clinical tool designed to measure a range of metacognitive skills essential for rehabilitation planning, monitoring an individual's progress, and evaluating the outcome of treatment interventions. The results of the present study indicated that the SRSI has sound interrater reliability and test–retest reliability. A principle components analysis revealed three SRSI factors: Awareness, Readiness to Change, and Strategy Behavior. A comparison between a group of 61 participants with acquired brain injury (ABI) and a group of 43 non-brain-injured participants indicated that the participants with ABI had significantly lower levels of Awareness and Strategy Behavior, but that level of Readiness to Change was not significantly different between the two groups. The significant relationship observed between the SRSI factors and measures of neuropsychological functioning confirmed the concurrent validity of the scale and supports the value of the SRSI for post-acute assessment.
Constraints on the Early Formation of Field Elliptical Galaxies

We present the results of an HK′ wide-field survey encompassing the Hubble Deep Field and its flanking fields. Our wide-field survey provides uniform coverage of a 61.8 arcmin2 area to a depth equivalent to K = 20.1 at 5 σ. We have also imaged the Hubble Deep Field in HK′, providing uniform coverage of a 7.8 arcmin2 area to a depth equivalent to K = 21.2 at 5 σ. Using these data in combination with new deep University of Hawaii 8K V and I imaging obtained on the Canada-France-Hawaii Telescope, we find only a small population of objects with colors redder than an equivalent I-K = 4, the color expected for an evolved elliptical galaxy at z > 1. We infer that only a fraction of the local field elliptical galaxy population with MK < -23.4 could have formed in single bursts at high redshift.
Psychological diagnostics in the talent development program of the German Soccer Association: A stepwise procedure to examine the relevance of personality characteristics in talented soccer players

The present study analyzes whether a multifaceted, football-specific and age-appropriate, Internet-based test battery in the talent development program of the German Football Association has acceptable psychometric properties in terms of reliability and validity. Additionally, the manuscript examines if this survey is affected by socially desirable responding (SDR). The study sample consists of male players within the U12 to U15 age groups. The psychological diagnostics capture personality characteristics assigned to motivation, volition, self-referential cognition, and emotion. A consistency analysis shows satisfying statistical values of Cronbach’s alpha, average inter-item correlation and corrected item-total correlation coefficients. Valid relationships between the psychological constructs were found. For the purpose of criterion validation, the comparison between a subgroup that was selected to a higher performance level and the total group of players illustrates the personality characteristics’ relationship with football performance. A comparison between an anonymous and personalized group as well as correlation of SDR scales with the psychological tests does reveal small effects of social desirability that should be further considered. These findings demonstrate a scientifically sound assessment of the personality characteristics within talented football players. Further research on the characteristics’ stability and prognostic power is needed to apply these diagnostics in order to support youth development in football.
Evidence for an Evolutionary Cheater Strategy—Relationships Between Primary and Secondary Psychopathy, Parenting, and Shame and Guilt

ABSTRACT In the present study, shame and guilt proneness were investigated in relation to primary and secondary psychopathy, looking at parental care as a possible mediator. A sample of 388 volunteers participated in an on-line study, completing several self-report measurements. Primary psychopathy, robust to parental care and sex of the participant, was associated with lower guilt proneness after a private transgression and lower negative self-evaluations after a public transgression. Secondary psychopathy was not associated with guilt or shame proneness. Paternal care played a mediating role between primary psychopathy and guilt, but only in male participants. High paternal care was associated with lower guilt repair in high psychopathy males, suggesting that a positive father-son relationship might be essential for development of exploitive strategies in primary psychopathy. The results highlight the fundamental differences between primary and secondary psychopathy, and provide support for the idea that primary psychopathy is an evolutionary cheater-strategy.
bZIP transcription factor interactions regulate DIF responses in Dictyostelium

The signalling molecule DIF-1 is required for normal cell fate choice and patterning in Dictyostelium. To understand how these developmental processes are regulated will require knowledge of how cells receive and respond to the DIF-1 signal. Previously, we have described a bZIP transcription factor, DimA, which is required for cells to respond to DIF-1. However, it was unknown whether DimA activity is required to activate the DIF response pathway in certain cells or is a component of the response pathway itself. In this study, we describe the identification of a DimA-related bZIP transcription factor, DimB. Rapid changes in the subcellular localisation of both DimA and DimB in response to DIF-1 suggest that they are directly downstream of the DIF-1 signal. Genetic and biochemical interactions between DimA and DimB provides evidence that their ability to regulate diverse targets in response to DIF-1 is partly due to their ability to form homo- and heterodimeric complexes. DimA and DimB are therefore direct regulators of cellular responses to DIF-1.
Visual Attention in Driving: The Effects of Cognitive Load and Visual Disruption

Objective: This study investigates the effect of cognitive load on guidance of visual attention. Background: Previous studies have shown that cognitive load can undermine driving performance, particularly drivers' ability to detect safety-critical events. Cognitive load combined with the loss of exogenous cues, which can occur when the driver briefly glances away from the roadway, may be particularly detrimental. Method: In each of two experiments, twelve participants engaged in an auditory task while performing a change detection task. A change blindness paradigm was implemented to mask exogenous cues by periodically blanking the screen in a driving simulator while a change occurred. Performance measures included participants' sensitivity to vehicle changes and confidence in detecting them. Results: Cognitive load uniformly diminished participants' sensitivity and confidence, independent of safety relevance or lack of exogenous cues. Periodic blanking, which simulated glances away from the roadway, undermined change detection to a greater degree than did cognitive load; however, drivers' confidence in their ability to detect changes was diminished more by cognitive load than by periodic blanking. Conclusion: Cognitive load and short glances away from the road are additive in their tendency to increase the likelihood of drivers missing safety-critical events. Application: This study demonstrates the need to consider the combined consequence of cognitive load and brief glances away from the road in the design of emerging in-vehicle devices and the need to provide drivers with better feedback regarding these consequences.
Validity of the Southern California Postrotary Nystagmus Test: misconceptions lead to incorrect conclusions.

I n her article entitled "Testing Vestibular Function: Problems With the Southern California Postrotary Nystagmus Test" (American Journal ofOccupational Therapy, July 1989), Helen Cohen concluded: "Although postrotatory nystagmus is indicative of vestibular system function, the SCPNT [Southern California Postrotary Nystagmus Test] does not provide a valid measure of that behavior. Therefore, results from this test are not valid indicators of vestibular function" (p. 475). Although Dr. Cohen is to be applauded for providing an excellent review of some aspects affecting the testing of pure vestibular responses and for attempting to educate therapists on the validity of a Widely used test, she has failed to recognize the distinction between the testing of pure vestibular responses and the purpose of the Southern California Postrotary Nystagmus Test (SCPNT) (Ayres, 1975). This distinction is central to the use and interpretation of results on the SCPNT. Ayres (1972, 1976, 1978, 1982) was consistent in conceptually and operationally defining the vestibular system in a much broader context than that described by Cohen, including the vestibular receptors "and all major neuronal mechanisms in· fluenced by sensory input from those receptors" (Ayres, 1978, p. 28). The vestibular receptors (semicircular canals and otoliths), vestibular nuclei, vestibulospinal pathways, vestibulocerebellar pathways, vestibuloocular pathways, and vestibulocortical projections are all considered to be components of the vestibular system (Clark, 1985). This view of the vestibular system emphasizes the global influences of vestibular stimuli processed within the central nervous Teri Wiss, Florence Clark
Effects of Excitative and Sedative Music on Subjective and Physiological Relaxation

Previous investigations using heart rate as a measure have not clarified the excitative-sedative effects of music. One of the sources of this failure was considered to be use of the index of heart rate. The present purpose was to examine the excitative-sedative effect of music on indices of the sympathetic and the parasympathetic nervous activities through spectral analysis of heart rate. The presented stimuli were three excitative musical pieces and three sedative ones. Subjective feelings about music were measured by an adjective checklist concerning musical activity. Heart-rate variabilities divided into two components of Low Frequency, mainly affected by the sympathetic nervous system and of High Frequency, mainly affected by the parasympathetic nervous system. Six types of heart-rate indices were employed: (1) mean increments from posttrial base, (2) coefficient of variances of heart rate, (3) mean powers of Low Frequency, (4) coefficient of component variances of Low Frequency, (5) mean powers of High Frequency, and (6) coefficient of component variances of High Frequency. From the factor analysis based on responses to an adjective checklist, there was a single major activity factor. Activity scores showed some were high during excitative pieces and others low during sedative ones. For heart rate, excitative-sedative effects of music were observed only in indices related to High Frequency. This result suggests that musical effect was observed in measures of the parasympathetic nervous system but not in the sympathetic nervous system.
An empirical time analysis of evolutionary algorithms as C programs

This article presents an empirical study devoted to characterize the computational efficiency behavior of an evolutionary algorithm (usually called canonical) as a C program. The study analyzes the effects of several implementation decisions on the execution time of the resulting evolutionary algorithm. The implementation decisions studied include: memory utilization (using dynamic vs. static variables and local vs. global variables), methods for ordering the population, code substitution mechanisms, and the routines for generating pseudorandom numbers within the evolutionary algorithm. The results obtained in the experimental analysis allow us to conclude that significant improvements in efficiency can be gained by applying simple guidelines to best program an evolutionary algorithm in C. Copyright © 2013 John Wiley & Sons, Ltd.
Community, Family, and Individual Factors Associated with Adolescents’ Vulnerability, Daily Stress, and Well-being Following Family Separation

ABSTRACT This study identified correlates of resilience among adolescents from separated families. Twenty-four adolescents (age 9–14 years) and their parents completed measures of sociodemographic risk and protective factors, interparental conflict, and adolescent responses to conflict. Adolescents reported their behavior, learning, mood, and anxiety difficulties as well as their stress and well-being using a 5-day diary. Resilient adolescents reported more constructive family representations, reported lower interparental conflict, and were from schools and neighborhoods that were more advantaged. Resilient adolescents reported significantly less stress across the diary days than vulnerable adolescents. The results of this study highlight the role of sociodemographic factors, family functioning, and adolescents’ own individual characteristics in their adjustment to their parents’ separation.
Analog predistortion for high power amplifier over the Ku-band (13,75–14,5 GHz)

This article presents a new analog predistortion linearizer to reduce non-linearity effects of Ku-band power amplifier. The structure is composed of Schottky diodes which create combinations of magnitude and phase distortions as function of biasing voltage. This method is compatible with different kind of amplifiers and broadband applications. Tested on a 250W travelling wave tube amplifier (TWTA), a maximum C/I3 (Carrier to 3rd order intermodulation ratio) and NPR (Noise Power Ratio) improvement of about 17dB and 10dB is obtained, respectively, over 750MHz bandwidth.
A novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1

ABSTRACT The spindle assembly checkpoint (SAC) is a surveillance mechanism that ensures accurate segregation of chromosomes into two daughter cells. BubR1, a key component of the SAC, also plays a role in the mitotic timing since depletion of BubR1 leads to accelerated mitosis. We previously found that mutation of the KEN1-box domain of Drosophila BubR1 (bubR1-KEN1 mutant) affects the binding of BubR1 to Cdc20, the activating co-factor of the APC/C, and does not accelerate the mitotic timing despite resulting in a defective SAC, which was unlike what was reported in mammalian cells. Here, we show that a mutation in a novel Drosophila short sequence (bubR1-KAN mutant) leads to an accelerated mitotic timing as well as SAC failure. Moreover, our data indicate that the level of Fzy, the Drosophila homolog of Cdc20, recruited to kinetochores is diminished in bubR1-KEN1 mutant cells and further diminished in bubR1-KAN mutant cells. Altogether, our data show that this newly identified Drosophila BubR1 KAN motif is required for a functional SAC and suggest that it may play an important role on Cdc20/Fzy kinetochore recruitment. Summary: We have identified a novel short motif sequence in the Drosophila BubR1 protein which when mutated affects the amount of Cdc20 recruited to the kinetochores and leads to an abrogation of the SAC.
Galaxy: a platform for interactive large-scale genome analysis.

Accessing and analyzing the exponentially expanding genomic sequence and functional data pose a challenge for biomedical researchers. Here we describe an interactive system, Galaxy, that combines the power of existing genome annotation databases with a simple Web portal to enable users to search remote resources, combine data from independent queries, and visualize the results. The heart of Galaxy is a flexible history system that stores the queries from each user; performs operations such as intersections, unions, and subtractions; and links to other computational tools. Galaxy can be accessed at http://g2.bx. psu.edu.
A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat

Therapies that restore renal cGMP levels are hypothesized to slow the progression of diabetic nephropathy. We investigated the effect of BI 703704, a soluble guanylate cyclase (sGC) activator, on disease progression in obese ZSF1 rats. BI 703704 was administered at doses of 0.3, 1, 3, and 10 mg/kg/d to male ZSF1 rats for 15 weeks, during which mean arterial pressure (MAP), heart rate (HR), and urinary protein excretion (UPE) were determined. Histologic assessment of glomerular and interstitial lesions was also performed. Renal cGMP levels were quantified as an indicator of target modulation. BI 703704 resulted in sGC activation, as evidenced by dose-dependent increases in renal cGMP levels. After 15 weeks of treatment, sGC activation resulted in dose-dependent decreases in UPE (from 463 ± 58 mg/d in vehicle controls to 328 ± 55, 348 ± 23, 283 ± 45, and 108 ± 23 mg/d in BI 703704-treated rats at 0.3, 1, 3, and 10 mg/kg, respectively). These effects were accompanied by a significant reduction in the incidence of glomerulosclerosis and interstitial lesions. Decreases in MAP and increases in HR were only observed at the high dose of BI 703704. These results are the first demonstration of renal protection with sGC activation in a nephropathy model induced by type 2 diabetes. Importantly, beneficial effects were observed at doses that did not significantly alter MAP and HR.
Assessing Physical Activity in Adolescents: Common Activities of Children in 6th–8th Grades

Objectives To provide data for physical activity assessment in practice by describing the leisure time activ‐ities of adolescents and determining if the activities and the metabolic equivalents (MET levels) of those activities differ for boys and girls. Data Sources The study was conducted in five middle schools in three rural counties in North Carolina. Subjectswere 1,211 6th, 7th, and 8th graders aged 11–14 (mean 12.2) years. Half (52.5%) were girls. The sample was 64% white, 24% African‐American and 12% other races. Results The top five activities of boys were football, basketball, bicycling, running, and baseball; the top five activities of girls were talking, running, walking, bicycling, and dancing. The average MET was 5.3 for boys and 4.3 for girls (p=0.000). By grade levels, 6th graders had an average MET of 4.9 and the MET of 8th graders was 4.5 (p<0.05). Older youth, girls, and children of parents with more education reported significantly more sedentary activities than the other youth. Implications for Practice Physical activity is an integral component of overall health. Once activities and activity levels are known, current practices can be aug‐mented or changed to accommodate improved understanding of physical activity. Because an active lifestyle is important in preventing obesity and other chronic conditions and for general health, nurse practitioners (NPs) should ask adolescents about their common activities and encourage them to continue the more vigorous activities and reduce time spent in sedentary pursuits. Prescriptive physical activity can be included for primary, secondary, or even tertiary prevention, thus crossing all levels of NP practice.
Xenogeneic transplantation of human spermatogonia

In the last 3 years, several studies have shown that xenogeneic transplantation of rodent spermatogonia is feasible. The treatment of infertile patients with spermatogenic arrest using the injection of immature germ cells has yielded only poor results. We attempted to establish a complete spermatogenetic line in the testes of mutant aspermatogenic (W/Wv) and severe combined immunodeficient mice (SCID) transplanted with germ cells from azoospermic men. Spermatogenic cells were obtained from testicular biopsy specimens of men (average age of 34.3 ± 9 years) undergoing infertility treatment because of obstructive and non-obstructive azoospermia. Testicular tissue was digested with collagenase to promote separation of individual spermatogenic cells. The germ cells were injected into mouse testicular seminiferous tubules using a microneedle (40 μm inner diameter) on a 10 ml syringe. To assess the penetration of the cell suspension into the tubules, trypan blue was used as an indicator. Mice were maintained for 50 to 150 days to allow time for germ cell colonisation and development prior to them being killed. Testes were then fixed for histological examination and approximately 100 cross-sectioned tubules were examined for human spermatogenic cells. A total of 26 testicular cell samples, 16 frozen and 10 fresh, were obtained from 24 men. The origin of the azoospermia was obstructive (OA) in 16 patients and non-obstructive (NOA) in 8 patients. The concentration of spermatogenic cells in the OA group was 6.6 × 106 cells/ml, and 1.3 ? 106 cells/ml in the NOA group (p < 0.01). The different spermatogenic cell types were distributed equally in the OA samples, ranging from spermatogenia to fully developed spermatozoa, but in the NOA group the majority of cells were spermatogonia and spermatocytes. A total of 23 testes from 14 W/Wv mice and 24 testes from 12 SCID mice were injected successfully, as judged by the presence of spermatogenic cells in histological sections of testes removed immediately after the injection. However, sections from the remaining testes examined up to 150 days after injection showed tubules lined with Sertoli cells and xenogeneic germ cells were not found. The reason why the two strains of mouse used as recipients did not allow the implantation of human germ cells is probably due to interspecies specificity involving non-compatible cell adhesion molecules and/or immunological rejection.
Norm- and Criterion-Referenced Testing

Tests can be categorized into two major groups: norm-referenced tests and criterion-referenced tests. These two tests differ in their intended purposes, the way in which content is selected, and the scoring process which defines how the test results must be interpreted. This brief paper will describe the differences between these two types of assessments and explain the most appropriate uses of each.
Caspofungin MIC Distribution amongst Commonly Isolated Candida Species in a Tertiary Care Centre - An Indian Experience.

INTRODUCTION Emergence of Candida species resistant to Amphotericin B and triazole has led to use of echinocandins, mostly caspofungin in the management of invasive candidiasis. There are some published reports of caspofungin resistance in Candida species yet no studies on caspofungin susceptibility pattern of Candida species exist in Indian setup. AIM To carry out the antifungal susceptibility of Candida isolates against caspofungin. MATERIALS AND METHODS In a retrospective study at a tertiary care teaching hospital, 60 preserved Candida isolates from inpatients of invasive candidiasis obtained over a period of 6 months from January 2015 to June 2015 were subjected to antifungal susceptibility to caspofungin and the Minimum Inhibitory Concentrations (MICs) of Candida species to caspofungin were determined by Epsilometer test (E-test). RESULTS Thirty Candida albicans and 30 Non albicansCandida mainly Candida glabrata, Candida parapsilosis and Candida tropicalis were tested for caspofungin susceptibitity by E-test. Caspofungin resistance was detected in 6.67% Candida albicans isolates. Caspofungin resistance was not observed in Candida parapsilosis, Candida glabrata and Candida tropicalis. This shows that caspofungin resistance is still rare. Further elaborate studies with clinical correlation data are needed to detect prevalence of caspofungin resistance. CONCLUSION Emergence of resistance in our study warrants need of elaborate studies with clinical correlation data to detect prevalence of resistance to caspofungin. E-test method proved to be an easy and simple technique for testing susceptibility of Candida to caspofungin.