Miracle-dz/UniFAR-FTUs huggingface dataset:
Highly skewed distribution of miRNAs and proteins between colorectal cancer cells and their exosomes following Cetuximab treatment: biomolecular, genetic and translational implications

Exchange of molecules via exosomes is a means of eukaryotic intercellular communication, especially within tumour microenvironments. However, no data are available on alterations of exosomal molecular cargo by environmental cues (eg, pharmacological treatments). To approach this issue, we compared the abundance of 754 miRNAs and 741 cancer-related proteins in exosomes secreted by Caco-2 (Cetuximab-responsive) and HCT- 116 (Cetuximab-resistant) CRC cells, before and after Cetuximab treatment, with that in their source cells. Cetuximab significantly altered the cargo of Caco-2 exosomes: it increased abundance of miRNAs and proteins activating proliferation and inflammation and reduced miRNAs and proteins related to immune suppression. These alterations did not precisely mirror those in source cells, suggesting a Cetuximab-linked effect. Analogous alterations were detected in HCT-116. Transfection of exosomes from Cetuximab-treated Caco-2 into HCT-116 significantly increased HCT-116 viability; conversely, no viability alteration was detected in Caco-2 transfected with exosomes from Cetuximab-treated HCT-116. Analysis of networks, comprising targets of differentially expressed (DE) exosomal miRNAs and DE exosomal proteins, demonstrates a significant involvement of processes related to proliferation, inflammation, immune response, apoptosis. Our data extend existing knowledge on molecular mechanisms of eukaryotic intercellular communication, especially in oncological processes. Their translation to clinical settings may add new weapons to existing therapeutic repertoires against cancer.
Global Games: Theory and Applications

Many economic problems are naturally modeled as a game of incomplete information, where a player’s payoff depends on his own action, the actions of others, and some unknown economic fundamentals. For example, many accounts of currency attacks, bank runs, and liquidity crises give a central role to players’ uncertainty about other players’ actions. Because other players’ actions in such situations are motivated by their beliefs, the decision maker must take account of the beliefs held by other players. We know from the classic contribution of Harsanyi (1967–1968) that rational behavior in such environments not only depends on economic agents’ beliefs about economic fundamentals, but also depends on beliefs of higher-order – i.e., players’ beliefs about other players’ beliefs, players’ beliefs about other players’ beliefs about other players’ beliefs, and so on. Indeed, Mertens and Zamir (1985) have shown how one can give a complete description of the “type” of a player in an incomplete information game in terms of a full hierarchy of beliefs at all levels. In principle, optimal strategic behavior should be analyzed in the space of all possible infinite hierarchies of beliefs; however, such analysis is highly complex for players and analysts alike and is likely to prove intractable in general. It is therefore useful to identify strategic environments with incomplete information that are rich enough to capture the important role of higher-order beliefs in economic settings, but simple enough to allow tractable analysis. Global games, first studied by Carlsson and van Damme (1993a), represent one such environment. Uncertain economic fundamentals are summarized by a state θ and each player observes a different signal of the state with a small amount of noise. Assuming that the noise technology is common knowledge among the players, each player’s signal generates beliefs about fundamentals, beliefs about other players’ beliefs about fundamentals, and so on. Our purpose in this paper is to describe how such models work, how global game reasoning can be applied to economic problems, and how this analysis relates to more general analysis of higher-order beliefs in strategic settings.
Differential space-time modulation

We consider the design of space-time modulation techniques that do not require channel estimates at the transmitter or receiver. We propose a general approach to differential modulation for multiple transmit antennas based on group codes. This approach can be applied to any number of transmit antennas and any signal constellation. We also derive low-complexity differential receivers, error bounds, and modulator design criteria, which we use to design optimal modulators for two transmit antennas.
The IrgA Homologue Adhesin Iha Is an Escherichia coli Virulence Factor in Murine Urinary Tract Infection

ABSTRACT The role of the Escherichia coli iron-regulated gene homologue adhesin (Iha) in the pathogenesis of urinary tract infections (UTIs) is unknown. We performed a series of complementary analyses to confirm or refute the hypothesis that Iha is a virulence factor in uropathogenic E. coli. Fecal E. coli isolates exhibited significantly lower prevalences of iha (range, 14 to 22%) than did clinical isolates from cases of pediatric cystitis or pyelonephritis, adult pyelonephritis or urosepsis, or bacteremia (range, 38 to 74%). Recombinant Iha from E. coli pyelonephritis isolate CFT073 conferred upon nonadherent E. coli ORN172 the ability to adhere to cultured T-24 human uroepithelial cells. In a well-established mouse model of ascending UTI, CFT073 and its derivative UPEC76 (a pap [P fimbriae] mutant version of strain CFT073) each significantly outcompeted their respective iha deletion mutants in CBA/J mice 48 h after bladder challenge (P < 0.03 for urine, both kidneys, and bladders of both constructs, except for bladders of mice challenged with UPEC76 and its deletion mutant, where P = 0.11). These data suggest that IhaCFT073 is a virulence factor and might be a target for anti-UTI interventions.
The Variability of " Normal " Galactic Nuclei

The Variability of "Normal" Galactic Nuclei Jacob Nelson Department of Physics and Astronomy Bachelor of Science It is likely that the nuclei of all galaxies contain black holes. If matter falls in toward the black hole, some of it can be heated an ejected creating an active nucleus. Astronomers monitor the infall and estimate black hole masses by measuring variations in the brightness of the nuclei. If all galaxies contain nuclear black holes, then all of them should vary in brightness, not just those termed active. The variability of these normal galactic nuclei will be less since a higher variability would have placed them in the active class. Using data obtained with a robotic telescope from 2004 to 2007, I investigated the variability in their nuclei.
Identifying Pre–High School Students’ Science Class Motivation Profiles to Increase Their Science Identification and Persistence

One purpose of this study was to determine whether patterns existed in pre–high school students’ motivation-related perceptions of their science classes. Another purpose was to examine the extent to which these patterns were related to their science identification, gender, grade level, class effort, and intentions to persist in science. We collected data from pre–high school students (Grades 5 through 7, 52.5% female, and 90.7% who self-identified as White) from 2 rural public schools in Southwest Virginia. Our analysis included data from 937 questionnaires that measured students’ perceptions of empowerment/autonomy, usefulness/utility value, expectancy for success, situational interest, and caring in science class. Using cluster analysis, we identified 5 clusters (i.e., “motivation profiles”) of students: (a) low motivation, (b) low usefulness and interest but high success and caring, (c) somewhat high motivation, (d) somewhat high motivation and high success and caring, and (e) high motivation. We tested the cluster stability by cluster analyzing subsamples by year of data collection and by grade level. Significant relationships existed between these motivation profiles and students’ science identification, gender, grade level, science class effort, and intentions to persist in science. These findings may support science educators in targeting students with similar motivation profiles rather than adhering to the difficult and often unrealistic task of catering to each student’s complex needs, individually.
Characteristics of Executive Functioning in a Small Sample of Children With Tourette Syndrome

Tourette syndrome (TS) is a disorder that involves at least one vocal tic and two or more motor tics; however, associated symptoms of obsessive-compulsive disorder (OCD) and attention-deficit disorder or attention-deficit hyperactivity disorder (ADHD) are common. Many children with TS exhibit educational difficulties and one possible explanation may be deficits in executive functioning. The focus of this study was to look at the severity of symptoms often associated with TS (tics and OCD and ADHD symptoms) and its potential relationship with the Behavior Rating Inventory of Executive Function (BRIEF) Parent Form in 11 children diagnosed with TS aged 8 to 14 years old. The parent of the child completed the BRIEF along with symptom measures evaluating tics, OCD behaviors, and ADHD symptoms. Despite relatively low mean scores on the symptom measures and just a few children exhibiting clinically significant scores on the BRIEF indexes, at least half the children exhibited abnormal scores on the Working Memory, Inhibit, and Shift subscales of the BRIEF. Varying patterns of relationships were found on the BRIEF subscales for each symptom severity scale. Results suggest that the BRIEF may be useful in determining the specific areas of difficulty in a population with variable symptomatology.
ON A SUBCLASS OF UNIFORMLY CONVEX FUNCTIONS INVOLVING CHO-SRIVASTAVA OPERATOR

G. Murugusundaramoorthy, S. Sivasubramanian, R. K. Raina Abstract. The authors introduce a new subclass UH(α, β, γ, δ, λ, k) of functions which are analytic in the open disc ∆ = {z ∈ C : |z| < 1}. Various results studied include the coefficient estimates and distortion bounds, radii of close-to-convexity, starlikeness and convexity and integral means inequalities for functions belonging to the above class. Relevances of the main results are also briefly indicated.
Force Budget: II. Application to Two-Dimensional Flow along Byrd Station Strain Network, Antarctica

Abstract Resistive stresses and velocities at depth are calculated along the Byrd Station Strain Network, Antarctica, using field data. There are found to be large longitudinal variations in basal drag and this result is little affected by errors in the input data or by uncertainties in the constitutive relation for ice. Basal drag varies by a factor of about 2 along the strain network, and is usually equal to the driving stress to within 10–20%. Sites of high drag are not always correlated with basal topographic highs, indicating that some process such as basal water drainage is involved in controlling the friction at the bed. Basal sliding velocities are very sensitive to errors in measured surface velocities and the rate factor in Glen’s flow law. As a result, calculated sliding velocities are much less reliable than deep stresses, and need to be interpreted with caution.
Design of IMM estimation with differential game based guidance system in maneuvering target interception

A differential game based guidance law for passive ranging system (i.e. Image IR seeker) is presented in this paper. The interceptor system equipped with the IR seeker which can provide good stealth capability during its course of tracking the maneuvering invaders. With target motion uncertainty, the passive ranging system integrates the Extended Kalman Filter (EKF) with the Interacting Multiple Model (IMM) technique to minimize the errors in estimating the range and range rates incurred by the target's maneuvering motion. The guidance law of the missile interceptor is designed based on linear differential game theory while considering the motion of the target in 3-D space such that the distance between the missile and the target is minimized. Finally, extensive simulations incorporating aerodynamic model are demonstrated to verify the validity of the proposed system, and the simulation results reveal that the mission of intercepting a maneuvering target is accomplished successfully.
Periodontal disease and coronary heart disease

BACKGROUND Several epidemiological studies have demonstrated an association between periodontal disease and coronary heart disease (CHD). The association could be a result of confounding by mutual risk factors. The present study was undertaken in a Danish population to reveal the significance of common risk factors. METHODS The investigation was conducted as a case-control study comprising 250 individuals: 110 individuals with verified CHD from a Department of Cardiovascular Medicine and 140 control individuals without CHD from the Copenhagen City Heart Study. Information on diabetic status, smoking habits, alcohol consumption, physical activity, school attendance, household income, body weight and height, triglyceride, and serum cholesterol was obtained. Full-mouth probing depth (PD), clinical attachment loss (CAL), bleeding on probing (BOP), and alveolar bone level (ABL) on radiographs were registered. ABL was stratified into ABL1=ABL<or=2 mm; ABL2=ABL>2 to <or=4 mm; and ABL3=ABL>4 mm. Multiple logistic regression models with stepwise backward elimination were used allowing variables with P<0.15 to enter the multivariate analysis. RESULTS The CHD group had a significantly lower outcome with respect to PD, BOP, CAL, and ABL. For participants<60 years old, only risk factors such as smoking and diabetic status entered the multivariate analysis. For the ABL3 group, there was a significant association with CHD for participants<60 years old, the odds ratio being 6.6 (1.69 to 25.6). For participants>or=60 years old, there was no association. CONCLUSIONS The present study showed a positive association between periodontal disease and CHD in agreement with several other studies. The association was highly age dependent and could only be attributed to diabetes and smoking to some extent.
The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish

ABSTRACT Autophagy is a highly conserved intracellular degradation system, and recently was shown to display circadian rhythms in mice. The mechanisms underlying circadian regulation of autophagy, however, are still unclear. Here, we observed that numbers of autophagosomes and autolysosomes exhibit daily rhythms in the zebrafish liver, and cebpb/(c/ebpβ) and various autophagy genes are rhythmically expressed in zebrafish larvae but significantly upregulated in per1b and TALEN-generated nr1d1/rev-erbα mutant fish, indicating that both Per1b and Nr1d1 play critical roles in autophagy rhythms. Luciferase reporter and ChIP assays show that the circadian clock directly regulates autophagy genes through Nr1d1, and also regulates transcription of cebpb through Per1b. We also found that fasting leads to altered expression of both circadian clock genes and autophagy genes in zebrafish adult peripheral organs. Further, transcriptome analysis reveals multiple functions of Nr1d1 in zebrafish. Taken together, these findings provide evidence for how the circadian clock regulates autophagy, imply that nutritional signaling affects both circadian regulation and autophagy activities in peripheral organs, and shed light on how circadian gene mutations act through autophagy to contribute to common metabolic diseases such as obesity.
Infusing Physical Activities Into the Classroom: Effects on Preschool Children's Geography Learning

In this intervention study, we investigated the effects of physical activities that were integrated into a geography task on preschool children's learning performance and enjoyment. Eight childcare centers with 87 four-to-five-year-old children were randomly assigned across an integrated physical activity condition, an unintegrated physical activity condition, and a control condition without physical activity. Children learned the names and a typical animal from each of the six continents using a floor-mounted world map with soft toy animals. Both learning conditions with physical activities showed higher performance than the learning condition without physical activities on an immediate retention test, and on a delayed retention test administered five weeks later. In addition, children in the physical activity conditions (integrated and nonintegrated) enjoyed their learning method the most. Infusing task-relevant physical activities into the classroom and the learning task is discussed as a promising way to improve children's learning, enjoyment, and health.
Personality Traits on Twitter—or—How to Get 1,500 Personality Tests in a Week

Psychology research suggests that certain personality traits correlate with linguistic behavior. This correlation can be effectively modeled with statistical natural language processing techniques. Prediction accuracy generally improves with larger data samples, which also allows for more lexical features. Most existing work on personality prediction, however, focuses on small samples and closed-vocabulary investigations. Both factors limit the generality and statistical power of the results. In this paper, we explore the use of social media as a resource for large-scale, open- vocabulary personality detection. We analyze which features are predictive of which personality traits, and present a novel corpus of 1.2M English tweets annotated with Myers-Briggs personality type and gender. Our experiments show that social media data can provide sufficient linguistic evidence to reliably predict two of four personality dimensions.
Bootstrapping Inductive and Coinductive Types in HasCASL

We discuss the treatment of initial datatypes and final process types in the wide-spectrum language HasCASL. In particular, we present specifications that illustrate how datatypes and process types arise as bootstrapped concepts using HasCASL's type class mechanism, and we describe constructions of types of finite and infinite trees that establish the conservativity of datatype and process type declarations adhering to certain reasonable formats. The latter amounts to modifying known constructions from HOL to avoid unique choice; in categorical terminology, this means that we establish that quasitoposes with an internal natural numbers object support initial algebras and final coalgebras for a range of polynomial functors, thereby partially generalising corresponding results from topos theory. Moreover, we present similar constructions in categories of internal complete partial orders in quasitoposes.
GPU-aware distributed quantum simulation

The simulation of algorithms from quantum computing is currently the most affordable solution for development of new applications. Due to the high computational cost of such simulation, solutions towards novel features that increase the performance are always desired. This work proposes an extension for the D-GM's simulation framework, establishing the support for GPU-aware distributed quantum simulation. The project explores the concepts of heterogeneous computing, merging distributed and GPU computing in a single programming environment. Our results comprehend the distributed simulation of systems comprised by Hadamard transformations up to 21 qubits. Detailed analysis and a performance comparison between PyCUDA and JCUDA frameworks for our application are discussed. This work is a significant step towards the ultimate goal of our project, which is the hybrid simulation of quantum algorithms, i.e., exploring multi-core CPUs and GPUs distributed along a cluster, achieving scalability when larger systems are simulated.
Gray Matter Correlates of Cognitive Performance Differ between Relapsing-Remitting and Primary-Progressive Multiple Sclerosis

Multiple Sclerosis (MS) is a chronic inflammatory/demyelinating and neurodegenerative disease of the central nervous system (CNS). Most patients experience a relapsing-remitting (RR) course, while about 15–20% of patients experience a primary progressive (PP) course. Cognitive impairment affects approximately 40–70% of all MS patients and differences in cognitive impairment between RR-MS and PP-MS have been found. We aimed to compare RR-MS and PP-MS patients in terms of cognitive performance, and to investigate the MRI correlates of cognitive impairment in the two groups using measures of brain volumes and cortical thickness. Fifty-seven patients (42 RR-MS, 15 PP-MS) and thirty-eight matched controls underwent neuropsychological (NP) testing and MRI. PP-MS patients scored lower than RR-MS patients on most of the NP tests in absence of any specific pattern. PP-MS patients showed significantly lower caudate volume. There was no significant difference in MRI correlates of cognitive impairment between the two groups except for a prevalent association with MRI measures of cortical GM injury in RR-MS patients and with MRI measures of subcortical GM injury in PP-MS patients. This suggests that although cognitive impairment results from several factors, cortical and subcortical GM injury may play a different role depending on the disease course.
Long homopurine•homopyrimidine sequences are characteristic of genes expressed in brain and the pseudoautosomal region

Homo(purine•pyrimidine) sequences (R•Y tracts) with mirror repeat symmetries form stable triplexes that block replication and transcription and promote genetic rearrangements. A systematic search was conducted to map the location of the longest R•Y tracts in the human genome in order to assess their potential function(s). The 814 R•Y tracts with ≥250 uninterrupted base pairs were preferentially clustered in the pseudoautosomal region of the sex chromosomes and located in the introns of 228 annotated genes whose protein products were associated with functions at the cell membrane. These genes were highly expressed in the brain and particularly in genes associated with susceptibility to mental disorders, such as schizophrenia. The set of 1957 genes harboring the 2886 R•Y tracts with ≥100 uninterrupted base pairs was additionally enriched in proteins associated with phosphorylation, signal transduction, development and morphogenesis. Comparisons of the ≥250 bp R•Y tracts in the mouse and chimpanzee genomes indicated that these sequences have mutated faster than the surrounding regions and are longer in humans than in chimpanzees. These results support a role for long R•Y tracts in promoting recombination and genome diversity during evolution through destabilization of chromosomal DNA, thereby inducing repair and mutation.
Configurons: Thermodynamic Parameters and Symmetry Changes at Glass Transition

Thermodynamic parameters of configurons - elementary excitations resulting from broken bonds in amorphous materials - are found from viscosity-temperature relationships. Glass-liquid transition phenomena and most popular models are described along with the configuron model of glass transition. The symmetry breaking, which occurs as a change of Hausdorff dimension of bonds, is examined at glass-liquid transition. Thermal history effects in the glass-liquid transition are interpreted in terms of configuron relaxation.