Miracle-dz/UniFAR-FTUs huggingface dataset:
Implementing Resident Research Program to Enhance Physicians Research in the United Arab Emirates

Objectives: The Dubai Residency Training Program (DRTP) commenced in the year 1993; then, a “Residency Research Program (RRP)” has implemented from 2011 to promote research among young physicians. This study was conducted by the Dubai Health Authority to review the RRP to assess its effectiveness in meeting original objectives and generating desired outcomes. Methods: Source documents such as the chronicles of the DRTP, communication between the stakeholders, resident feedback, research director, and program director reports were accessed and retrospectively reviewed. Results: Seven research workshops and ten advanced statistics courses were held. Ten scholarships were provided to the residents for “Introduction to Clinical Research Training” held by Harvard Medical School. Of 370 residents, a total of 156 residents submitted their research proposal, of which 128 residents presented their thesis. Nineteen residents presented their research on international conferences, 12 published their study, and 9 got award locally. Conclusions: Efforts are focused on improving the quality of the research projects, as well as getting residents involved in research that leads eventually to publication. Research is a major component of DRTP; nevertheless, it is challenging for residents to conduct research successfully because of some barriers inherent in residency training. This experience was the first in the United Arab Emirates, and we believe that this paper will contribute to the integrating research in residency programs by the educators and academics in across countries within the region.
Molecular Mechanism for LAMP1 Recognition by Lassa Virus

ABSTRACT Lassa virus is a notorious human pathogen that infects many thousands of people each year in West Africa, causing severe viral hemorrhagic fevers and significant mortality. The surface glycoprotein of Lassa virus mediates receptor recognition through its GP1 subunit. Here we report the crystal structure of GP1 from Lassa virus, which is the first representative GP1 structure for Old World arenaviruses. We identify a unique triad of histidines that forms a binding site for LAMP1, a known lysosomal protein recently discovered to be a critical receptor for internalized Lassa virus at acidic pH. We demonstrate that mutation of this histidine triad, which is highly conserved among Old World arenaviruses, impairs LAMP1 recognition. Our biochemical and structural data further suggest that GP1 from Lassa virus may undergo irreversible conformational changes that could serve as an immunological decoy mechanism. Together with a variable region that we identify on the surface of GP1, those could be two distinct mechanisms that Lassa virus utilizes to avoid antibody-based immune response. IMPORTANCE Structural data at atomic resolution for viral proteins is key for understanding their function at the molecular level and can facilitate novel avenues for combating viral infections. Here we used X-ray protein crystallography to decipher the crystal structure of the receptor-binding domain (GP1) from Lassa virus. This is a pathogenic virus that causes significant illness and mortality in West Africa. This structure reveals the overall architecture of GP1 domains from the group of viruses known as the Old World arenaviruses. Using this structural information, we elucidated the mechanisms for pH switch and binding of Lassa virus to LAMP1, a recently identified host receptor that is critical for successful infection. Lastly, our structural analysis suggests two novel immune evasion mechanisms that Lassa virus may utilize to escape antibody-based immune response.
Double-logarithms in N=8 supergravity: impact parameter description and mapping to 1-rooted ribbon graphs

The set of double-logarithmic (DL) contributions $(\alpha \, t \ln^2 {s})^n$ to the 4-graviton amplitude in ${\cal N}$$=$ 8 supergravity (SUGRA), with $\alpha$ being the gravitational coupling and $(s,t)$ the Mandelstam invariants, is studied in impact parameter ($\rho$) representation. This sector of the amplitude shows interesting properties which shed light on the nature of quantum corrections in gravity. Besides having a convergent behaviour as $s$ increases, which is not present in ${\cal N}$$<$ 4 SUGRA theories, there exists a critical line $\rho_c(s)$ above which the Born amplitude prevails. The short distance region $\rho < \rho_c(s)$ is dominated by the DL terms. As a consequence, when studied in terms of an eikonal approach in the forward limit, the scattering angle linked to the bending of the semiclassical trajectory of the graviton shows a transition from attractive gravity at large distances to a region at small $\rho$ characterized by a repulsive DL contribution to the gravitational potential due to the gravitino content of the theory. In the complex angular momentum plane, this DL high energy asymptotics is driven by the rightmost pole singularity of a parabolic cylinder function. The resummation of DL quantum corrections in ${\cal N}$$=$ 8 SUGRA can be understood in terms of the counting of 1-rooted maps on orientable surfaces.
Rates and Odds Ratios for Complications in Closed and Open Tibial Fractures Treated With Unreamed, Small Diameter Tibial Nails: A Multicenter Analysis of 467 Cases

Objective A multicenter trial analyzed complications and odds for complications in open and closed tibial fractures stabilized by small diameter nails. Design Retrospective. Setting Four Level I trauma centers. Patients Four hundred sixty-seven tibial fractures were included in the study. There were fifty-two proximal fractures, 219 midshaft fractures, and 196 distal fractures. Breakdown into different AO/OTA groups showed 135 Type A fractures, 216 Type B fractures, and 116 Type C fractures. Two hundred sixty-five were closed fractures and 202 were open fractures. Outcome Measurements Clinical and radiographic analysis. Methods 467 patients' tibial fractures were stabilized with small diameter tibial nails using an unreamed technique. Indications for the use of small diameter tibial nails using an unreamed technique included all types of open or closed diaphyseal fractures. The operating surgeons decided whether or not to ream based on personal experience, fracture type, and soft-tissue damage. Surgeons of Center 1 preferred to treat AO Type A and B fractures with unreamed nails, and surgeons of Centers 2, 3, and 4 preferred to treat AO Type B and C fractures with unreamed nails. Closed and open fractures were treated in approximately the same ratio. Results Analysis showed five (1.1 percent) deep infections (with a 5.4 percent rate of deep infections in Gustilo Grade III open fractures), forty-three delayed unions (9.2 percent), and twelve (2.6 percent) nonunions. Compartment syndromes occurred in sixty-two cases (13.3 percent), screw fatigue in forty-seven cases (10 percent), and fatigue failure of the tibial nail in three cases (0.6 percent). Conclusions Fracture distraction of more than three millimeters should not be tolerated when stabilizing tibial fractures with unreamed, small-diameter nails as this increases the odds of having a delayed union by twelve times (p < 0.001) and a nonunion by four times (p = 0.057). There was a significant increase of complications in the group of Grade III open fractures (p < 0.001), AO/OTA Type C fractures (p = 0.002), and to a lesser extent in distal fractures. However, the rate of severe complications resulting in major morbidity was low.
Management of occult invasive cervical cancer found after simple hysterectomy.

BACKGROUND To estimate safety and efficacy of radical parametrectomy (RP) and radiation therapy (RT) or concurrent chemoradiation therapy (CCRT) for patients with occult invasive cervical cancer found after simple hysterectomy. MATERIALS AND METHODS We retrospectively evaluated outcomes in 147 patients with occult invasive cervical cancer. RESULTS Forty-eight patients with IA1 lesions (IA1 group) did not receive further treatment. Of the 99 patients with IA2-IIA lesions, 26 received no definitive treatment (observation group), 44 received RT or CCRT (RT/CCRT group), and 29 underwent RP (RP group). After a median follow-up of 116 months (range 3-235 months), recurrent disease was observed in 0%, 34.6%, 6.8%, and 0% of patients in the IA1, observation, RT/CCRT, and RP groups, respectively. In the RT/CCRT group, treatment was delayed due to severe diarrhea in 4 patients (9%) and 12 patients (27%) had late complications related to RT requiring further management (including two surgical interventions). Five patients in the RP group (17%) experienced perioperative complications which were easily managed, intraoperatively or conservatively. Late complications were not observed in the RP group. CONCLUSION Although RP and RT/CCRT had similar therapeutic efficacy, the lower rate of late complications observed with RP makes it preferable to RT/CCRT.
Circulation of Mumps Virus Genotypes in Spain from 1996 to 2007

ABSTRACT Although the WHO recommends the use of genotyping as a tool for epidemiological surveillance for mumps, limited data on mumps virus (MV) genotype circulation that may be used to trace the patterns of virus spread are available. We describe the first complete series of data from Spain. The small hydrophobic region was sequenced from 237 MV-positive samples from several regions of Spain collected between 1996 and 2007. Six different genotypes were identified: A, C, D (D1), G (G1, G2), H (H1, H2), and J. Genotype H1 was predominant during the epidemic that occurred from 1999 to 2003 but was replaced by genotype G1 as the dominant genotype in the epidemic that occurred from 2005 to 2007. The same genotype G1 strain caused concomitant outbreaks in different parts of the world (the United States, Canada, and the United Kingdom). The remaining genotypes (genotypes A, C, D, and J) appeared in sporadic cases or small limited outbreaks. This pattern of circulation seems to reflect continuous viral circulation at the national level, despite the high rates of vaccine coverage.
Inclusive Fitness Affects Both Prosocial and Antisocial Behavior: Target Gender and Insult Domain Moderate the Link between Genetic Relatedness and Aggression

Although prior research has examined the relationship between genetic relatedness and helping behavior (Burnstein, Crandall, and Kitayama, 1994), less is known about its role in aggressive responses to insults (Fitzgerald and Ketterer, 2011). Drawing on inclusive fitness theory (Hamilton, 1964) and the Kinship, Acceptance, and Rejection Model of Altruism and Aggression (KARMAA; Webster, 2008; Webster et al., 2012), we designed a 2 (participant gender) × 2 (target gender) × 2 (insult: status vs. reproductive) × 3 (relatedness: stranger vs. cousin vs. sibling) between-person experiment in which 489 participants (a) read vignettes in which a stranger, cousin, or sibling was insulted and (b) reported their emotional reaction and retaliation likelihood (six-item α= .91) in response to the insult. Consistent with theory and prior research, men were significantly more aggressive than women, and people were significantly more aggressive responding to insults against kin than non-kin. These findings support theoretically-derived, dynamic, and domain-specific links among insults, gender, relatedness, and aggression.
Ack kinase regulates CTP synthase filaments during Drosophila oogenesis

The enzyme CTP synthase (CTPS) dynamically assembles into macromolecular filaments in bacteria, yeast, Drosophila, and mammalian cells, but the role of this morphological reorganization in regulating CTPS activity is controversial. During Drosophila oogenesis, CTPS filaments are transiently apparent in ovarian germline cells during a period of intense genomic endoreplication and stockpiling of ribosomal RNA. Here, we demonstrate that CTPS filaments are catalytically active and that their assembly is regulated by the non‐receptor tyrosine kinase DAck, the Drosophila homologue of mammalian Ack1 (activated cdc42‐associated kinase 1), which we find also localizes to CTPS filaments. Egg chambers from flies deficient in DAck or lacking DAck catalytic activity exhibit disrupted CTPS filament architecture and morphological defects that correlate with reduced fertility. Furthermore, ovaries from these flies exhibit reduced levels of total RNA, suggesting that DAck may regulate CTP synthase activity. These findings highlight an unexpected function for DAck and provide insight into a novel pathway for the developmental control of an essential metabolic pathway governing nucleotide biosynthesis.
Semiclassical Faddeev approximation for electron loss in fast heavy-ion collisions

The ionisation of the projectile in collisions with heavy targets is described by means of the Faddeev expansion. The series is cut off after five terms, which means an inclusion of higher-order interactions of the electron with both the target and the projectile in a symmetric way. This approximation is compared with several theories suggested in the literature. Numerical calculations are presented for the energy distribution of electrons emitted in the forward direction in the case of (H, Ne) collisions.
A field test for host fruit odour discrimination and avoidance behaviour for Rhagoletis pomonella flies in the western United States

Prezygotic isolation due to habitat choice is important to many models of speciation‐with‐gene‐flow. Habitat choice is usually thought to occur through positive preferences of organisms for particular environments. However, avoidance of non‐natal environments may also play a role in choice and have repercussions for post‐zygotic isolation that preference does not. The recent host shift of Rhagoletis pomonella (Diptera: Tephritidae) from downy hawthorn, Crataegus mollis, to introduced apple, Malus domestica, in the eastern United States is a model for speciation‐with‐gene‐flow. However, the fly is also present in the western United States where it was likely introduced via infested apples ≤ 60 years ago. R. pomonella now attacks two additional hawthorns in the west, the native C. douglasii (black hawthorn) and the introduced C. monogyna (English ornamental hawthorn). Flight tunnel tests have shown that western apple‐, C. douglasii‐ and C. monogyna‐origin flies all positively orient to fruit volatile blends of their respective natal hosts in flight tunnel assays. Here, we show that these laboratory differences translate to nature through field‐trapping studies of flies in the state of Washington. Moreover, western R. pomonella display both positive orientation to their respective natal fruit volatiles and avoidance behaviour (negative orientation) to non‐natal volatiles. Our results are consistent with the existence of behaviourally differentiated host races of R. pomonella in the west. In addition, the rapid evolution of avoidance behaviour appears to be a general phenomenon for R. pomonella during host shifts, as the eastern apple and downy hawthorn host races also are antagonized by non‐natal fruit volatiles.
The influence of product aesthetics and usability over the course of time: a longitudinal field experiment

A longitudinal field experiment was carried out over a period of 2 weeks to examine the influence of product aesthetics and inherent product usability. A 2 × 2 × 3 mixed design was used in the study, with product aesthetics (high/low) and usability (high/low) being manipulated as between-subjects variables and exposure time as a repeated-measures variable (three levels). A sample of 60 mobile phone users was tested during a multiple-session usability test. A range of outcome variables was measured, including performance, perceived usability, perceived aesthetics and emotion. A major finding was that the positive effect of an aesthetically appealing product on perceived usability, reported in many previous studies, began to wane with increasing exposure time. The data provided similar evidence for emotion, which also showed changes as a function of exposure time. The study has methodological implications for the future design of usability tests, notably suggesting the need for longitudinal approaches in usability research. Practitioner Summary: This study indicates that product aesthetics influences perceived usability considerably in one-off usability tests but this influence wanes over time. When completing a usability test it is therefore advisable to adopt a longitudinal multiple-session approach to reduce the possibly undesirable influence of aesthetics on usability ratings.
Proposal of a New Scoring Scheme for the Diagnosis of Noninvasive Endocervical Glandular Lesions

The differential diagnosis of endocervical glandular lesions can be very difficult, and the interobserver agreement on borderline cases can be low. We are proposing a new scoring system to aid in the reproducibility of the diagnosis of noninvasive endocervical glandular lesions. The total of 67 diagnostically difficult cases were independently reviewed by five pathologists. After the completion of the first round review, a consensus diagnosis was reached for each lesion by all participants. This consensus diagnosis was used as the reference diagnosis. According to the consensus, the lesions included 21 benign/reactive conditions, 7 endocervical glandular dysplasias, and 39 adenocarcinomas in situ. During the second round review, all cases were assessed using the new scoring scheme, according to which separate scores from 0 to 3 were given to each lesion for: 1) nuclear atypia, 2) stratification, and 3) sum of mitoses/apoptoses (counted in the two most active glands, and the average number used). These three scores were then added to result in the total score (0–3 = benign; 4–5 = endocervical glandular dysplasia; 6–9 = adenocarcinoma in situ). Complete agreement between all observers in the first round review was seen in 35 of 67 cases (52.2%), kappa = 0.565. This agreement improved in the second round with the use of the scoring scheme: 52 of 67 cases (77.6%), kappa = 0.705. If the benign and endocervical glandular dysplasia diagnostic categories were combined, the overall agreement in the second round review would be 63 of 67 cases (94%), meaning that the scheme affords accurate distinction between adenocarcinoma in situ and lesser lesions. We propose applying this new scoring scheme to the diagnosis of noninvasive endocervical glandular lesions to improve interobserver agreement. The use of this scheme will result in more consistency of data in series from different institutions and will allow uniformity on the issue of adenocarcinoma in situ precursor lesions.
Mineral loss and color change of enamel after bleaching and staining solutions combination

Abstract. Pigments of food and beverages could affect dental bleaching efficacy. The aim of this investigation was to evaluate color change and mineral loss of tooth enamel as well as the influence of staining solutions normally used by adolescent patients undergoing home bleaching. Initial hardness and baseline color were measured on enamel blocks. Specimens were divided into five groups (n=5): G1 (control) specimens were kept in artificial saliva throughout the experiment (3 weeks); G2 enamel was exposed to 10% carbamide peroxide for 6 h daily, and after this period, the teeth were cleaned and stored in artificial saliva until the next bleaching session; and G3, G4, and G5 received the same treatments as G2, but after bleaching, they were stored for 1 h in cola soft drink, melted chocolate, or red wine, respectively. Mineral loss was obtained by the percentage of hardness reduction, and color change was determined by the difference between the data obtained before and after treatments. Data were subjected to analysis of variance and Fisher’s test (α=0.05). G3 and G5 showed higher mineral loss (92.96±5.50 and 94.46±1.00, respectively) compared to the other groups (p≤0.05). G5 showed high-color change (9.34±2.90), whereas G1 presented lower color change (2.22±0.44) (p≤0.05). Acidic drinks cause mineral loss of the enamel, which could modify the surface and reduce staining resistance after bleaching.
Some Uses of Happiness Data in Economics

Happiness research is based on the idea that it is fruitful to study empirical measures of individual welfare. The most common is the answer to a simple well-being question such as "Are you Happy? " Hundreds of thousands of individuals have been asked this question, in many countries and over many years. Researchers have begun to use these data to tackle a variety of important questions in economics. Some require strong assumptions concerning interpersonal comparisons of utility, but others make only mild assumptions in this regard. They range from microeconomic questions, such as the way income and utility are connected, to macroeconomic questions such as the tradeoff between inflation and unemployment, including large areas in political economy. Public policy is another area where progress using happiness data is taking place. Given the central role of utility notions in economic theory, we argue that the use of happiness data in empirical research should be given serious consideration.
Smoking and associated factors among young Swedish females.

OBJECTIVE To analyse the smoking habits of young females and various associated factors. DESIGN Cross-sectional population study; questionnaire with fixed-response options. SETTING Upper secondary schools in the municipalities of Ludvika and Smedjebacken in central Sweden. SUBJECTS 524 girls aged 16-19; response rate 85%. MAIN OUTCOME MEASURES Social smoking, daily smoking, heavy smoking. RESULTS The following causes of social smoking among 16-17-year-old girls were identified: a dismissive attitude to the danger of smoking, maternal smoking, and being sexually experienced. A dismissive attitude to smoking and maternal smoking were the corresponding causes among 18-19-year-olds. A practical school curriculum, lack of interest in sports, smoking by one's best friend, maternal smoking, and a desire for weight control were the causes of daily smoking among 16-17-year-olds. Smoking by one's best friend, maternal smoking, and a dismissive attitude to smoking were the corresponding causes among 18-19-year-olds. CONCLUSIONS The most important cause of social smoking among female 16-19-year-olds was a dismissive attitude to the dangers of smoking. The causes of daily smoking and heavy smoking were more complex, particularly among 16-17-year-olds, and included various social characteristics and habits of the respondents.
Physical Performance, Balance, Mobility, and Muscle Strength Decline at Different Rates in Elderly People

[Purpose] The aim of this study was to verify the decline in functionality of elderly people. [Subjects and Methods] The study subjects comprised 152 individuals (96 women; 56 men) divided into 3 groups: G1 (60 to 69 years, n=53); G2 (70 to 79 years, n=65); and G3 (80 years or older, n=34). Physical performance, balance, mobility, and muscle strength were assessed using Short Physical Performance Battery (SPPB), Berg Balance Scale (BERG), Timed Up and Go (TUG) test, and leg press test, respectively. Comparison among age-stratified groups (G1, G2 and G3) and between genders were examined using analysis of variance with Tukey’s test as a post hoc test or the Kruskal-Wallis test with Bonferroni correction. [Results] SPPB and BERG scores decreased significantly in comparison between G1 and G3, and between G2 and G3 in women. TUG and leg press scores decreased significantly in comparison between G1 and G3 and between G2 and G3. [Conclusion] People in their 60s and 70s have similar functional characteristics (physical performance, balance, mobility and muscle strength for both genders), and functionality starts to decline when people are in their 80s.