Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic Value of Bone Marrow FDG Uptake Pattern of PET/CT in Newly Diagnosed Diffuse Large B-cell Lymphoma

Purpose: The value of 18F-fluorodeoxyglucose positron emission tomography /computed tomography (18F-FDG PET/CT) in assessing bone marrow involvement (BMI) of lymphoma remains controversial. The present study aims to evaluate the prognostic meaning of bone marrow FDG uptake pattern in PET/CT of newly diagnosed diffuse large B-cell lymphoma (DLBCL) patients. Materials and Methods: 193 newly diagnosed DLBCL patients were retrospectively analyzed. All patients received 6-8 cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). The type of BM FDG uptake pattern was recorded by two blinded reviewers independently. The relationship between clinicopathologic features and BM patterns was analyzed. The prognostic value of different BM patterns was evaluated by Log-rank test and Cox-regression analysis. Results: Out of 193 patients, 28 (15%) patients had focal BM FDG uptake higher than liver (fPET+), 18 (9%) patients showed diffuse BM uptake higher than liver (dPET+) and 147 (76%) patients had normal BM uptake (lower than liver) (nPET). BMB positive was found in 35.7% (10/28) of fPET+ patients, in 16.7% (3/18) of dPET+ patients and in 0.7% (1/147) of nPET patients. Diffuse BM pattern was associated with lower hemoglobin level and a trend of higher erythrocyte sedimentation rate (ESR). dPET+ patients had similar 3y-progression-free survival (3y-PFS) and 3y-overall survival (3y-OS) compared with nPET patients (80.5% vs 81.5%, p=0.701; 94.1% vs 90.6%, p=0.809, respectively), while fPET+ patients had worse 3y-PFS and 3y-OS compared with fPET- patients (32.7% vs 81.4%, p<0.001; 69.4% vs 90.9%, p=0.003, respectively). Multivariate analysis showed fPET+ (HR=2.270, p=0.025) and stage III/IV (HR=4.909, p=0.026) were independent predictors for PFS, but no factors were independently predictive for OS. Conclusion: PET/CT-directed BM patterns are meaningful in predicting prognosis of newly diagnosed DLBCL patients. Focal BM pattern is an independent predictor for PFS.
Anatomical distribution of musculoskeletal disorders following a road traffic collision in litigants presenting to physiotherapists within a private-clinic in North-East England

ABSTRACT Introduction: Musculoskeletal disorders (MSDs) are common following a road traffic collision (RTC) in England. Establishing the anatomical distribution of MSDs following RTC that present to physiotherapists may improve understanding and clinical practice. This study examined anatomical distribution of MSDs that present to physiotherapists within a litigant population following a RTC in England. Methods: A retrospective review of physiotherapy records was conducted at a private practice in North-East England. Data were collected from 2105 patients between January 2014 and December 2015. The primary outcome was anatomical regions with MSDs. Descriptive data is reported. Results: Overall, 90% of patients presented with a neck/upper back disorder, while 52% presented with a lower back disorder. Of the assessed patients, 46% presented with one MSD, 45% presented with two MSDs while 9% presented with ≥3 MSDs. Further analysis showed that those who presented to physiotherapy later and were not motor vehicle occupants (MVOs) were more likely to have upper-limb, lower-limb, or lumbar MSDs. Younger patients, who presented sooner and were non-MVO were more likely to have multiple regions affected by MSDs. Conclusions: This study presents epidemiological evidence that MSDs following a RTC occur primarily in the neck/upper back or lower back regions, and that multiple MSDs are common.
A Literature Review of Studies Evaluating Rotator Cuff Activation during Early Rehabilitation Exercises for Post-Op Rotator Cuff Repair

Wells SN, Schilz JR, Uhl TL, Gurney B. A Literature Review of Studies Evaluating Rotator Cuff Activation during Early Rehabilitation Exercises for Post-Op Rotator Cuff Repair. JEPonline 2016;19(3):70-99. Despite the modern advancement of surgical repair equipment and techniques, many rotator cuff repairs do not clinically heal. Prescribed rehabilitative exercises must appropriately load the repaired muscle-tendon complex to promote healing and prevent capsular adhesions without damaging the repair. The clinician must possess an understanding of the anatomy and physiology of the healing rotator cuff, and understand the importance of the plane of movement, speed of the movement, position of the extremity, level of assistance, and type of resistance used. Electromyography (EMG) provides a useful means to determine muscle activation levels during specific exercises. Descriptions of specific exercises and EMG activation as they relate to the rotator cuff muscles are described. The specific performance of the exercises, the reliability of such EMG measures, and the descriptive figures are described. Practicing clinicians will benefit from the correct interpretation of the EMG data, and how it can be used in the exercise prescription when formulating a treatment plan.
The Potential Effect of Chinese Herbal Formula Hongqijiangzhi Fang in Improving NAFLD: Focusing on NLRP3 Inflammasome and Gut Microbiota

The present study investigates the potential therapeutic mechanism underlying the effects of the Chinese herbal formula Hongqijiangzhi Fang (HJF) on nonalcoholic fatty liver disease (NAFLD) in rats. Male Sprague Dawley (SD) rats were randomly divided into 4 groups (n = 8): control group was fed a normal diet, three other groups were fed high-fat diets (HFD), and the two treatment groups were intragastrically given a compound probiotic or HJF during the molding time. After 16 w, related indices were detected. The results showed that HJF significantly reduced abdominal aorta serum cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), IL-1β, and IL-18, portal venous serum lipopolysaccharide (LPS), and liver TC and TG levels in HFD-fed rats. HJF ameliorated hepatic steatosis in the liver and improved the intestinal barrier in HFD-fed rats. Activation of the NLRP3 inflammasome was reduced by HJF in HFD-fed rats. Additionally, the abundances of A. muciniphila (Verrucomicrobiaceae), F. rappini (Helicobacteraceae), and Enterobacteriaceae bacteria significantly decreased in HJF-treated HFD-fed rats. In conclusion, these result suggested that the Chinese herbal formula HJF reduced hepatic steatosis maybe through decreasing certain gut bacteria (such as Enterobacteriaceae bacteria and F. rappini), alleviating intestinal endotoxemia and reducing NLRP3 inflammasome activation.
First-time application of biomordants in conjunction with the Alkanna tinctoria root extract for eco-friendly wool dyeing

ABSTRACT Associated environmental hazards with the use of synthetic dyes and toxic metal mordants in the textile industry lead to concerns for alternatives. Natural dyes and biomordants are the new eco-friendly and biocompatible resources for textile coloration obtained from never-ending natural flora. The coloration potential of naphthoquinone-based colorants from Alkanna tinctoria roots on wool was investigated in this study with the application of both metallic mordants as well as biomordants. Color characteristics were evaluated on a spectrophotometer under the D65 illuminant, 10° standard observer, and fastness properties by using standard methods. A wide range of shades was obtained with good color characteristics and fastness results. Iron among metallic mordants, pomegranate peel extract (PPE) and babool among biomordants increased the color yield of dyed wool. Scanning electron microscopy (SEM) confirmed the undamaged physical structure and surface morphology of dyed wool.
Antioxidant Vitamin C Prevents Decline in Endothelial Function during Sitting

Background This study was designed to test the hypothesis that antioxidant Vitamin C prevents the impairment of endothelial function during prolonged sitting. Material/Methods Eleven men (24.2±4.4 yrs) participated in 2 randomized 3-h sitting trials. In the sitting without vitamin C (SIT) and the sitting with vitamin C (VIT) trial, participants were seated for 3 h without moving their legs. Additionally, in the VIT trial, participants ingested 2 vitamin C tablets (1 g and 500 mg) at 30 min and 1 h 30 min, respectively. Superficial femoral artery (SFA) flow-mediated dilation (FMD) was measured hourly for 3 h. Results By a 1-way ANOVA, there was a significant decline in FMD during 3 h of SIT (p<0.001). Simultaneously, there was a significant decline in antegrade (p=0.04) and mean (0.037) shear rates. For the SIT and VIT trials by a 2-way (trial × time) repeated measures ANOVA, there was a significant interaction (p=0.001). Pairwise testing revealed significant between-SFA FMD in the SIT and VIT trial at each hour after baseline, showing that VIT prevented the decline in FMD 1 h (p=0.009), 2 h (p=0.016), and 3 h (p=0.004). There was no difference in the shear rates between SIT and VIT trials (p>0.05). Conclusions Three hours of sitting resulted in impaired SFA FMD. Antioxidant Vitamin C prevented the decline in SFA FMD, suggesting that oxidative stress may contribute to the impairment in endothelial function during sitting.
Detection of occult simian immunodeficiency virus SIVsmm infection in asymptomatic seronegative nonhuman primates and evidence for variation in SIV gag sequence between in vivo- and in vitro-propagated virus

Polymerase chain reaction techniques were used to identify simian immunodeficiency virus (SIV) SIVsmm gag sequences in genomic DNA isolated from peripheral blood mononuclear cells from naturally infected asymptomatic seropositive and seronegative sooty mangabeys (Cercocebus atys) and from experimentally infected but asymptomatic rhesus macaques (Macaca mulatta). The results indicate that most if not all SIV-seronegative mangabeys from the colony at the Yerkes Primate Center are in fact infected with SIVsmm despite their lack of humoral immune response, confirming previous immunological and virological observations made by our laboratory. Sequence analysis of these particular gag fragments from the mangabey revealed an average of 88% nucleotide sequence homology but 97% amino acid identity with the previously published sequence of the SIVsmmH4 clone. The significance of this finding relative to the asymptomatic state of SIV-infected mangabeys and disease-susceptible SIV-infected rhesus macaques is discussed.
Matrine Exerts Antidepressant-Like Effects on Mice: Role of the Hippocampal PI3K/Akt/mTOR Signaling

Abstract Background Current antidepressants in clinical use always take weeks or even months to exert full therapeutic effects, and sometimes have serious side effects. Thus, it is very necessary to develop novel antidepressants with better efficacy and fewer adverse effects. The present study focused on investigating the antidepressant potential of matrine and its possible mechanisms of action. Methods The forced swim test, tail suspension test, and chronic unpredictable mild stress model of depression were used to reveal the antidepressant-like effects of matrine on mice. Western blotting, immunohistochemistry, and lentivirus were further used together to explore the antidepressant mechanism of matrine. Results It was found that matrine exhibited significant antidepressant actions in the forced swim test and tail suspension test without affecting the locomotor activity of mice. Chronic matrine administration fully reversed the chronic unpredictable mild stress-induced depressive-like symptoms in forced swim test, tail suspension test, and sucrose preference test. After that, western blotting analysis revealed that chronic matrine treatment restored the decreasing effects of chronic unpredictable mild stress on the PI3K/Akt/mammalian target of rapamycin signaling in hippocampus, but not prefrontal cortex. Furthermore, pharmacological and genetic blockade of the PI3K/Akt/mammalian target of rapamycin signaling in hippocampus abolished the antidepressant actions of matrine on mice. Conclusions Taken together, matrine produces antidepressant-like effects on mice via promoting the hippocampal PI3K/Akt/ mammalian target of rapamycin signaling.
Association of WWOX rs9926344 polymorphism with poor prognosis of hepatocellular carcinoma

Introduction: The WW domain-containing oxidoreductase (WWOX), widely expressed in human tissues, is considered as a tumor suppressor gene and plays an important role in the incidence and progression of human cancer, HCC included. This study was to investigate the correlation between single nucleotide polymorphisms (SNPs) of the WWOX gene and the prognosis of hepatocellular carcinoma (HCC) patients. Materials and Methods: After a total of 152 HCC patients were recruited, 8 cases with tumor recurrence within 2-years after operation and 8 cases without recurrence were selected randomly for SNP genotyping and screening using Affymetrix Array 6.0. And then we confirmed candidate SNPs in the remaining 136 patients by time-of-flight mass spectrometry (TOF-MS). Results: In total, 32 SNPs were screened and identified as candidate SNPs with one SNP in particular, (rs9926344), being further verified to be valuable. We found that AA+AG genotype and A allele of WWOX rs9926344 were significantly associated with recurrent risk of HCC (p=0.002 and p=0.001, respectively). The Kaplan-Meier curve showed that patients carrying rs9926344 AA +AG genotype had poor RFS (P=0.004) and OS (P=0.005) compared to those carrying GG genotypes. The multivariate COX regression analysis showed that the AA+AG genotype were an independent prognostic factor for tumor recurrence (HR 1.787, 95% CI 1.042-3.064, P=0.035). Furthermore, IHC analysis showed that the WWOX protein down-regulation is more frequent in patients with AG genotype compared to those with GG genotype (P=0.023). Conclusion: Our findings indicate that WWOX rs9926344 polymorphism is positively correlated with tumor recurrence and can be used as an independent prognostic marker for HCC patients after operation.
Direction sensitive fall detection using a triaxial accelerometer and a barometric pressure sensor

Falling is one of the leading causes of serious health decline or injury-related deaths in the elderly. For survivors of a fall, the resulting health expenses can be a devastating burden, largely because of the long recovery time and potential comorbidities that ensue. The detection of a fall is, therefore, important in care of the elderly for decreasing the reaction time by the care-givers especially for those in care who are particularly frail or living alone. Recent advances in motion-sensor technology have enabled wearable sensors to be used efficiently for pervasive care of the elderly. In addition to fall detection, it is also important to determine the direction of a fall, which could help in the location of joint weakness or post-fall fracture. This work uses a waist-worn sensor, encompassing a 3D accelerometer and a barometric pressure sensor, for reliable fall detection and the determination of the direction of a fall. Also assessed is an efficient analysis framework suitable for on-node implementation using a low-power micro-controller that involves both feature extraction and fall detection. A detailed laboratory analysis is presented validating the practical application of the system.
Movement patterns and activity of the Brazilian snake-necked turtle Hydromedusa maximiliani (Testudines: Chelidae) in southeastern Brazil

To investigate the movement patterns and activity of Hydromedusa maximiliani in southeastern Brazil, sixteen adult freshwater turtles (eight males and eight females) were monitored with radio-transmitters from October 2009 to November 2010. An additional 22 turtles (11 males and 11 females) were monitored with thread-bobbins over a 3-day period. Hydromedusa maximiliani showed strong tendency to remain close to the river course. The distance moved each day varied from 0 to 179 m/day (radio-tracking) and 1.5 to 201 m/day (thread-bobbins). Males moved greater distances than females during the mating season (August to November), while females exhibited pronounced movements associated with egg-laying (December to February). Male and female movements did not differ significantly. Straight line distance measurements, usually obtained by radio-tracking, underestimate actual movement distances, since the nonlinearity of movements is not captured by radio-tracking as opposed to spool tracking, even when long distances are travelled. Results from this study are important for establishing conservation strategies for this vulnerable species.
Detecting Popular Temporal Modes in Population-scale Unlabelled Trajectory Data

With the rapid process of urbanization, revealing the underlying mechanisms behind urban mobility has become a crucial research problem. The movements of urban dwellers are often constituted by their daily routines, and exhibit distinct and contextual temporal modes, i.e., the patterns of individuals allocating their time across different locations. In this paper, we investigate a novel problem of detecting popular temporal modes in population-scale unlabelled trajectory data. Our key finding is that the detected temporal modes capture the semantic feature of human's living style, and is able to unravel meaningful correlations between urban mobility and human behavior. Specifically, we represent the temporal mode of a trajectory as a partition of the time duration, where the time slices associated with same locations are partitioned into same subsets. Such abstraction decouples the temporal modes from actual physical locations, and allows individuals with similar temporal modes yet completely different physical locations to have similar representations. Based on this insight, we propose a pipeline system composed of three components: 1) noise handler that eliminates the noises in the raw mobility records, 2) representation extractor for temporal modes, and 3) popular temporal modes detector. By applying our system on three real-world mobility datasets, we demonstrate that our system effectively detects the popular temporal modes embedded in population-scale mobility datasets, which is easy to be interpreted and can be justified through the associated PoIs and mobile applications usage. More importantly, our further experiments reveal insightful correlations between the popular temporal modes and individuals' social economic status, i.e. occupation information, which sheds light on the mechanisms behind urban mobility.
Improving Implicit Discourse Relation Classification by Modeling Inter-dependencies of Discourse Units in a Paragraph

We argue that semantic meanings of a sentence or clause can not be interpreted independently from the rest of a paragraph, or independently from all discourse relations and the overall paragraph-level discourse structure. With the goal of improving implicit discourse relation classification, we introduce a paragraph-level neural networks that model inter-dependencies between discourse units as well as discourse relation continuity and patterns, and predict a sequence of discourse relations in a paragraph. Experimental results show that our model outperforms the previous state-of-the-art systems on the benchmark corpus of PDTB.
Walk-Steered Convolution for Graph Classification

Graph classification is a fundamental but challenging issue for numerous real-world applications. Despite recent great progress in image/video classification, convolutional neural networks (CNNs) cannot yet cater to graphs well because of graphical non-Euclidean topology. In this article, we propose a walk-steered convolutional (WSC) network to assemble the essential success of standard CNNs, as well as the powerful representation ability of random walk. Instead of deterministic neighbor searching used in previous graphical CNNs, we construct multiscale walk fields (a.k.a. local receptive fields) with random walk paths to depict subgraph structures and advocate graph scalability. To express the internal variations of a walk field, Gaussian mixture models are introduced to encode the principal components of walk paths therein. As an analogy to a standard convolution kernel on image, Gaussian models implicitly coordinate those unordered vertices/nodes and edges in a local receptive field after projecting to the gradient space of Gaussian parameters. We further stack graph coarsening upon Gaussian encoding by using dynamic clustering, such that high-level semantics of graph can be well learned like the conventional pooling on image. The experimental results on several public data sets demonstrate the superiority of our proposed WSC method over many state of the arts for graph classification.
Relationship between pain outcomes and smoking history following video-assisted thoracic surgery for lobectomy: a retrospective study

Purpose The relationship between chronic smoking history and postoperative pain remains controversial. This study aimed to elucidate this relationship in non-small cell lung cancer (NSCLC) patients who underwent video-assisted thoracic surgery (VATS) lobectomy. Patients and methods This retrospective observational study included NSCLC patients treated with VATS lobectomy between January 2011 and July 2017. Demographic and clinical information, including preoperative smoking history, was collected. The primary goal was to investigate the relationship between smoking history and postoperative pain outcomes (oral morphine equivalent [OME] consumption and pain score). Multivariate linear regression analysis was performed, and P<0.05 was considered as statistically significant. Results A total of 1,785 patients were included in the final analysis. Multivariate linear regression analysis revealed that total smoking amount (in packs), status as current smoker, and cessation time did not have an association with OME consumption (mg) or pain scores on postoperative days 0–2 (P>0.05). However, patients who had never smoked consumed less morphine equivalent analgesics (mg) on postoperative days 0–2 (coefficient: −17.48, 95% CI [−33.83, −1.13], P=0.036) compared to patients who had a history of smoking. Conclusion Patients who had never smoked had lower opioid analgesics consumption on the days immediately following surgery, while being a current smoker or the total amount of smoking in packs did not affect postoperative pain outcomes after VATS lung lobectomy.