Miracle-dz/UniFAR-FTUs huggingface dataset:
Hamilton-Jacobi theory in multisymplectic classical field theories

The geometric framework for the Hamilton-Jacobi theory developed in the studies of Carinena et al. [Int. J. Geom. Methods Mod. Phys. 3(7), 1417–1458 (2006)], Carinena et al. [Int. J. Geom. Methods Mod. Phys. 13(2), 1650017 (2015)], and de Leon et al. [Variations, Geometry and Physics (Nova Science Publishers, New York, 2009)] is extended for multisymplectic first-order classical field theories. The Hamilton-Jacobi problem is stated for the Lagrangian and the Hamiltonian formalisms of these theories as a particular case of a more general problem, and the classical Hamilton-Jacobi equation for field theories is recovered from this geometrical setting. Particular and complete solutions to these problems are defined and characterized in several equivalent ways in both formalisms, and the equivalence between them is proved. The use of distributions in jet bundles that represent the solutions to the field equations is the fundamental tool in this formulation. Some examples are analyzed and, in particular, the H.
Functional brain networks: great expectations, hard times and the big leap forward

Many physical and biological systems can be studied using complex network theory, a new statistical physics understanding of graph theory. The recent application of complex network theory to the study of functional brain networks has generated great enthusiasm as it allows addressing hitherto non-standard issues in the field, such as efficiency of brain functioning or vulnerability to damage. However, in spite of its high degree of generality, the theory was originally designed to describe systems profoundly different from the brain. We discuss some important caveats in the wholesale application of existing tools and concepts to a field they were not originally designed to describe. At the same time, we argue that complex network theory has not yet been taken full advantage of, as many of its important aspects are yet to make their appearance in the neuroscience literature. Finally, we propose that, rather than simply borrowing from an existing theory, functional neural networks can inspire a fundamental reformulation of complex network theory, to account for its exquisitely complex functioning mode.
How Changes in Entry Requirements Alter the Teacher Workforce and Affect Student Achievement

We are in the midst of what amounts to a national experiment in how best to attract, prepare, and retain teachers, particularly for high-poverty urban schools. Using data on students and teachers in grades 38, this study assesses the effects of pathways into teaching in New York City on the teacher workforce and on student achievement. We ask whether teachers who enter through new routes, with reduced coursework prior to teaching, are more or less effective at improving student achievement. When compared to teachers who completed a university-based teacher education program, teachers with reduced coursework prior to entry often provide smaller initial gains in both mathematics and English language arts. Most differences disappear as the cohort matures, and many of the differences are not large in magnitude, typically 2 to 5 percent of a standard deviation. The variation in effectiveness within pathways is far greater than the average differences between pathways.
A framework for network utility maximization in VANETs

Vehicular Ad hoc Networks (VANETs) are expected to have great potential to improve both traffic safety and comfort in the future. Safety and traffic related applications will typically use broadcast-based communication schemes to disseminate messages within the network. Existing strategies to reduce redundant retransmissions and to improve reliability and efficiency of message dissemination rely on inflexible transmission limitations.They are not adequate to efficiently deal with the limited network resources efficiently both in sparse and in dense networks. Apart from that, they do not take into account the individual network nodes' interest in information. The goal of our concept is to provide network participants with data that has the highest utility for them with a latency as small as possible, independent of the actual network load. Our concept envisages the context-adaptive differentiation of data traffic according to current information relevance to allow for an optimal utilization of the limited network resources. In this paper, we propose methodologies for quantifying message relevance, present different mechanisms for realizing data prioritization and compare our solution with the IEEE 802.11e approach. http://www.christoph-schroth.de
Prevalence of Oxaliplatin-induced Chronic Neuropathy and Influencing Factors in Patients with Colorectal Cancer in Iran.

BACKGROUND The chemotherapeutic agent oxaliplatin can cause acute and chronic forms of peripheral neuropathy. The aim of this study was to evaluate the incidence of chronic neuropathy and its risk factors in colorectal cancer (CRC) patients treated with FOLFOX or XELOX regimens in the Oncology Ward of Hazrat-e-Rasoul Hospital in Tehran. MATERIALS AND METHODS A total of 130 patients with CRC were entered into our study, aged over 18 years, without history of receiving other neurotoxic agents or other predisposing factors such as diabetes or neurologic diseases and kidney and liver dysfunction. For the FOLFOX regimen, patients received oxaliplatin, 85 mg/m2, every 2 weeks for 12 courses and with the XELOX regimen, oxaliplatin was 130 mg/m(2), every 3 weeks for 8 courses. Based on Common Toxicity Criteria (CTC or NCI-CTC v.3), the patients were divided into 5 groups (grades) based on the severity of their symptoms. RESULTS Fifty-seven patients (43.8%) were male and 73(56.2%) female. Some 19 patients (14.7%) had BMI<20, 97(74.6%) were between 20-25 and 14 (10.8%) ≥ 25. In 105 patients (80.7%) neuropathy was found. There was significant correlation between BMI, hypomagnesaemia and especially, severity of anemia in patients with neuropathy compared to those without. CONCLUSIONS Oxaliplatin regimens can induce chronic neuropathy in CRC patients, with anemia, high BMI and hypomagnesaemia as risk factors that can predispose to this kind of neurotoxicity.
Red Shift, Blue Shift: Investigating Doppler Shifts, Blubber Thickness, and Migration as Explanations of Seasonal Variation in the Tonality of Antarctic Blue Whale Song

The song of Antarctic blue whales (Balaenoptera musculus intermedia) comprises repeated, stereotyped, low-frequency calls. Measurements of these calls from recordings spanning many years have revealed a long-term linear decline as well as an intra-annual pattern in tonal frequency. While a number of hypotheses for this long-term decline have been investigated, including changes in population structure, changes in the physical environment, and changes in the behaviour of the whales, there have been relatively few attempts to explain the intra-annual pattern. An additional hypothesis that has not yet been investigated is that differences in the observed frequency from each call are due to the Doppler effect. The assumptions and implications of the Doppler effect on whale song are investigated using 1) vessel-based acoustic recordings of Antarctic blue whales with simultaneous observation of whale movement and 2) long-term acoustic recordings from both the subtropics and Antarctic. Results from vessel-based recordings of Antarctic blue whales indicate that variation in peak-frequency between calls produced by an individual whale was greater than would be expected by the movement of the whale alone. Furthermore, analysis of intra-annual frequency shift at Antarctic recording stations indicates that the Doppler effect is unlikely to fully explain the observations of intra-annual pattern in the frequency of Antarctic blue whale song. However, data do show cyclical changes in frequency in conjunction with season, thus suggesting that there might be a relationship among tonal frequency, body condition, and migration to and from Antarctic feeding grounds.
Pivotal role of the renin-angiotensin system in Lyon hypertensive rats.

We assessed the role of the renin-angiotensin system (RAS) in Lyon genetically hypertensive (LH) and normotensive (LN) rats by measuring 1) kidney renin and prorenin contents; 2) effects of early, prolonged angiotensin-converting enzyme (ACE) inhibition on blood pressure (BP) and regional hemodynamics; and 3) acute and chronic responses to angiotensin II (ANG II) and norepinephrine (NE). At the adult age, LH rats differed from LN rats by elevated BP, left ventricle weight, and vascular resistances, especially in the kidneys, associated with lower kidney renin and prorenin contents. ACE inhibition (perindopril, 3 mg.kg-1.24 h-1 orally from 3 to 15 wk of age) suppressed the development of hypertension, cardiac hypertrophy, and the increase in renal vascular resistances. No specific hypersensitivity to ANG II could be disclosed in acute conditions. In perindopril-treated LH rats, a 4-wk infusion of ANG II (200 ng.kg-1.min-1) but not of NE (1,000 ng.kg-1.min-1) restored hypertension, mimicked the hemodynamic alterations seen in untreated LH rats, and produced a brief sodium retention. It is concluded that in LH rats, despite a low basal renin secretion, hypertension and hemodynamic abnormalities 1) are fully dependent on an active RAS and 2) may involve an enhanced sensitivity to the chronic effects of ANG II.
HerMES: a search for high-redshift dusty galaxies in the HerMES Large Mode Survey – catalogue, number counts and early results

Selecting sources with rising flux densities towards longer wavelengths from Herschel/Spectral and Photometric Imaging Receiver (SPIRE) maps is an efficient way to produce a catalogue rich in high-redshift (z > 4) dusty star-forming galaxies. The effectiveness of this approach has already been confirmed by spectroscopic follow-up observations, but the previously available catalogues made this way are limited by small survey areas. Here we apply a map-based search method to 274 deg^2 of the Herschel Multi-tiered Extragalactic Survey (HerMES) Large Mode Survey and create a catalogue of 477 objects with SPIRE flux densities S_(500) > S_(350) > S_(250) and a 5σ cut-off S_(500) > 52 mJy. From this catalogue we determine that the total number of these ‘red’ sources is at least an order of magnitude higher than predicted by galaxy evolution models. These results are in agreement with previous findings in smaller HerMES fields; however, due to our significantly larger sample size we are also able to investigate the shape of the red source counts for the first time. We have obtained spectroscopic redshift measurements for two of our sources using the Atacama Large Millimeter/submillimeter Array. The redshifts z = 5.1 and 3.8 confirm that with our selection method we can indeed find high-redshift dusty star-forming galaxies.
Social Circles of Children with Language Impairment

Social Circles of Children with Language Impairment Erin Whitworth Department of Communication Disorders, BYU Master of Science Children with language impairment (LI) often demonstrate difficulties in social communication. The purpose of this pilot study was to examine the quantity and quality of the social interactions of children with LI and their typical peers through an analysis of the social networks or circles of each child. Eight children with LI as well as eight children with typically developing language and their parents were interviewed. Children’s social networks were organized by social circles to effectively paint a picture of each child’s social communication (Blackstone & Hunt Berg, 2003). Children with LI were found to have overall fewer contacts in their social circles than children with typical language; they also interacted with fewer peers than did children with typical language. The children with LI interacted with more adults who were paid or obligated to interact with them than did their typical peers. Information about the nature of social interactions of children with LI as well as those of children with typical language was obtained from parent interviews. Qualitative observations from the parent interviews demonstrated that the Internet was not used as a significant mode of communication for children in this age group, although the children who used it to communicate were all from the Typical group. Most parents reported that children spent the most time and talked the most with immediate family members. A greater number of parents of children with LI than parents of children with typical language skills reported their children to have people they would like to talk to but did not. Parents of children with LI also reported their children to use fewer topics in conversation than were reported by parents of their typical peers. With few exceptions, parents of children in both groups reported that their children talked mostly about concrete rather than abstract topics. More parents of children with LI than those with typical language indicated that their children had topics they would like to talk about but did not or lacked the ability to do so.
Cytotoxic effects of D-glucosamine on the ultrastructures of normal and neoplastic tissues in vivo.

SUMMARY The effects of D-glucosamine on the fine structures of Walker carcinoma and of the liver and kidney in rats were studied in vivo. Continuous administration of D-glucosamine for 18 hr resulted in a slight dilation of the cisternae of the endoplasmic reticulum and Golgi sacs of the tumor cells and liver parenchymal cells. The epithelial cells of the renal tubules contained lamellar structures within numerous autophagic vacuoles. Infusion of D-glucosamine for 40 hr resulted in conspicuous degenerative changes in the nuclei and nucleoli of the Walker tumor cells. The nuclear matrix showed a much-decreased electron density and contained clumped interchromatin granules. The nucleoli had rounded up, and the strands of the nucleolonema had coalesced. Conspicuous small aggregates of high contrast, probably representing chromatin, had formed predominantly in the electron-lucent areas of the nucleolus. Cytoplasmic changes in tumor cells were relatively slight. The parenchymal cells of the liver showed almost complete fragmentation of the long profiles of the rough endoplasmic reticulum into small vesicles. Only single rows of the usual staggered array of cisternae remained surrounding mitochondria. Autophagic vacuoles were frequently seen. The lining epithelium of the proximal convoluted tubules of the kidney showed striking vesiculation of the cytoplasm. At no time was necrosis of the renal or hepatic cells observed. The most significant finding was the complete necrosis of tumor cells in rats sacrificed 5 days after 40 hr of infusion with D-glucosamine. This was accompanied by a remarkable recovery of the fine structure of the renal and hepatic parenchymal cells.
Phosphorylation and Dephosphorylation among Dif Chemosensory Proteins Essential for Exopolysaccharide Regulation in Myxococcus xanthus

ABSTRACT Myxococcus xanthus social gliding motility, which is powered by type IV pili, requires the presence of exopolysaccharides (EPS) on the cell surface. The Dif chemosensory system is essential for the regulation of EPS production. It was demonstrated previously that DifA (methyl-accepting chemotaxis protein [MCP]-like), DifC (CheW-like), and DifE (CheA-like) stimulate whereas DifD (CheY-like) and DifG (CheC-like) inhibit EPS production. DifD was found not to function downstream of DifE in EPS regulation, as a difD difE double mutant phenocopied the difE single mutant. It has been proposed that DifA, DifC, and DifE form a ternary signaling complex that positively regulates EPS production through the kinase activity of DifE. DifD was proposed as a phosphate sink of phosphorylated DifE (DifE∼P), while DifG would augment the function of DifD as a phosphatase of phosphorylated DifD (DifD∼P). Here we report in vitro phosphorylation studies with all the Dif chemosensory proteins that were expressed and purified from Escherichia coli. DifE was demonstrated to be an autokinase. Consistent with the formation of a DifA-DifC-DifE complex, DifA and DifC together, but not individually, were found to influence DifE autophosphorylation. DifD, which did not inhibit DifE autophosphorylation directly, was found to accept phosphate from autophosphorylated DifE. While DifD∼P has an unusually long half-life for dephosphorylation in vitro, DifG efficiently dephosphorylated DifD∼P as a phosphatase. These results support a model where DifE complexes with DifA and DifC to regulate EPS production through phosphorylation of a downstream target, while DifD and DifG function synergistically to divert phosphates away from DifE∼P.
Histologic Characteristics of the Human Prepuce Pertaining to its Clinical Behavior as a Dual Graft

The aim of this study was to investigate the unique histologic structure of the normal human prepuce, paying particular attention to the resemblance and dissimilarities between the inner (ie, mucosa) and outer (ie, skin) layers. Histologic sections were stained using hematoxylin–eosin and Van Gieson stains. Transmission electron microscopy was used to evaluate the ultrastructure. Dense capillary networks can be observed in both the upper and lower dermal zones. The dermis lacks a dense collagenous zone. Melanocytes could not be observed in the mucosa. Elastin fibers and bundles were very abundant and dense. Early edema formation can be explained by the loose character of the dermal structure. Better graft “take” in mucosal grafts may be the result of the dense vascular dermal network. Mild hyperpigmentation can be explained by the limited number of melanocytes. However, this can also be observed in mucosal grafts, despite the absence of melanocytes. This may be solely the result of inflammatory hyperpigmentation, which can be seen in skin grafts. The abundance of elastin fibers in the prepuce may be the reason behind the superior wound contraction inhibition.
Differential Effect of Endothelin‐1 on Renal Regional Blood Flow: Role of Nitric Oxide

Summary: This study evaluated the effects of endothelin-1 (ET-1) on medullary and cortical blood flow (MBF and CBF, respectively) and the interactions with other local vasoactive systems in the regulation of renal regional blood flow. CBF and MBF were measured simultaneously by laser-Doppler flowmetry in anesthetized Wistar rats. Administration of ET-1 (1.0 nmol/kg, i.v.) produced a decrease in CBF (δ= - 20%) and at the same time increased MBF (δ= +24%). In the presence of nitric oxide (NO) blockade by L-NAME, the vasodilatory effect of ET-1 on MBF was completely blocked and actually reversed (δ= - 19%), whereas the cortical vasoconstrictor effect was potentiated (δ = −31%). Cyclo-oxygenase inhibition with indomethacin attenuated the vasodilator effect of ET-1 on MBF (δ = + 12%) but did not affect the changes in CBF. Therefore, ET-1 exerts a differential effect on intrarenal regional blood flow, i.e., a decrease in CBF and an increase in MBF. The medullary vasodilator action of the peptide is dependent on an intact NO system and, to a lesser extent, on prostaglandin synthesis.
Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions

Activating neurotrophic tyrosine receptor kinase (NTRK) fusions, typically detected using nucleic-acid based assays, are highly targetable and define certain tumors. Here, we explore the utility of pan-TRK immunohistochemistry (IHC) to detect NTRK fusions. NTRK rearrangements were detected prospectively using MSK-IMPACT, a DNA-based next-generation sequencing assay. Transcription of novel NTRK rearrangements into potentially functional fusion transcripts was assessed via Archer Dx fusion assay. Pan-Trk IHC testing with mAb EPR17341 was performed on all NTRK rearranged cases and 20 cases negative for NTRK fusions on Archer. Of 23 cases with NTRK rearrangements, 15 had known activating fusions. Archer detected fusion transcripts in 6 of 8 novel NTRK rearrangements of uncertain functional significance. Pan-Trk IHC was positive in 20 of 21 cases with NTRK fusion transcripts confirmed by Archer. The discordant negative case was a mismatch repair- deficient colorectal carcinoma with an ETV6-NTRK3 fusion. All 20 additional Archer-negative cases had concordant pan-TRK IHC results. Pan-Trk IHC sensitivity and specificity for transcribed NTRK fusions was 95.2% and 100%, respectively. All positive IHC cases had cytoplasmic staining while the following fusion partner-specific patterns were discovered: all 5 LMNA-NTRK1 fusions displayed nuclear membrane accentuation, all 4 TPM3/4 fusions displayed cellular membrane accentuation, and half (3/6) of ETV6-NTRK3 fusions displayed nuclear staining. Pan-Trk IHC is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma. Pan-Trk IHC can help determine whether translation occurs for novel NTRK rearrangements.
Comparison the Effect of Extra Corporeal Shockwave Therapy with Low Dosage Versus High Dosage in Treatment of the Patients with Lateral Epicondylitis

Background: One of the most common reasons of elbow and forearm pain is lateral epicondylitis diagnosed based on clinical examination. The extracorporeal shock wave therapy is applied for less invasive treatments with different dosages. This study aimed to investigate the effects of high- and low-dose ESW in treating the lateral epicondylitis. Materials and Methods: This clinical trial was done in Al Zahra medical center on 40 patients who were selected randomly and divided into two groups. After VAS, the first group was treated by Duolith SD1 shock wave, energy of 0.25 mj/mm2, 1000 shocks; the second was treated by focus with the energy of 0.10 mj/mm2, 1000 shocks per session for 15 minutes with weekly intervals in three sessions. The patients were also treated with drugs (NSAIDs) and the visual analog scale (VAS) was reassessed 1 week after the last session and 12 weeks after finishing the treatment. Results: The mean of pain intensity during study was decreased in the two groups but reduction of pain intensity in the low-dose groups was higher than the high-dose groups (P = 0.001). Changes in other parameters including wrist extension test, middle finger extension test and PG was also similar. Conclusion: Extra corporeal shockwave therapy can be effective in treating lateral epicondylitis, but its effects usually appear in after 2 or 3 months and using the low dose of this treating method has more desirable therapeutic effects.