Miracle-dz/UniFAR-FTUs huggingface dataset:
Globally optimal segmentation of multi-region objects

Many objects contain spatially distinct regions, each with a unique colour/texture model. Mixture models ignore the spatial distribution of colours within an object, and thus cannot distinguish between coherent parts versus randomly distributed colours. We show how to encode geometric interactions between distinct region+boundary models, such as regions being interior/exterior to each other along with preferred distances between their boundaries. With a single graph cut, our method extracts only those multi-region objects that satisfy such a combined model. We show applications in medical segmentation and scene layout estimation. Unlike Li et al. [17] we do not need “domain unwrapping” nor do we have topological limits on shapes.
The Effects of Tempur Insoles on Ground Reaction Forces and Loading Rates in Running

Runners often experience over-use injuries. Ground reaction force (GRFs) patterns have been associated with these over-use injuries; however, it is not solely the magnitude of GRFs, but also the rate at which they are applied that lead to lower extremity injury. Many recreational runners will use over-the-counter insoles as a method of treating or preventing injury. Therefore, the purpose of this study was to examine the efficacy of two insoles on peak GRFs and loading rates. It was hypothesized that no differences in peak GRFs or loading rates would exist with the addition of two insoles during running. Twelve subjects (7 females; 5 males) performed seven running trials in each of the following conditions: no insoles (NORM), over-the-counter insoles (OTC) and memory-foam insoles (TEMPUR). GRFs were recorded using a force plate (1440Hz; AMTI) while subjects ran across a 15 meter lab. A 2 x 3 (gender x insole) repeated measures ANOVA was used to compare the effects of insoles on loading rate and ground reaction forces. Alpha level was set at p <0.05. The current study found no statistical differences in loading rate or GRFs between the insole and no insole conditions. Furthermore, there was no gender effect in any condition. The findings of the current study suggest that insoles do not attenuate shock or decrease loading rate. The lack of shock attenuation associated with insoles suggests they do not protect the lower extremity from injury.
A systematic review of economic evaluations of population-based sodium reduction interventions

Objective To summarise evidence describing the cost-effectiveness of population-based interventions targeting sodium reduction. Methods A systematic search of published and grey literature databases and websites was conducted using specified key words. Characteristics of identified economic evaluations were recorded, and included studies were appraised for reporting quality using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results Twenty studies met the study inclusion criteria and received a full paper review. Fourteen studies were identified as full economic evaluations in that they included both costs and benefits associated with an intervention measured against a comparator. Most studies were modelling exercises based on scenarios for achieving salt reduction and assumed effects on health outcomes. All 14 studies concluded that their specified intervention(s) targeting reductions in population sodium consumption were cost-effective, and in the majority of cases, were cost saving. Just over half the studies (8/14) were assessed as being of ‘excellent’ reporting quality, five studies fell into the ‘very good’ quality category and one into the ‘good’ category. All of the identified evaluations were based on modelling, whereby inputs for all the key parameters including the effect size were either drawn from published datasets, existing literature or based on expert advice. Conclusion Despite a clear increase in evaluations of salt reduction programs in recent years, this review identified relatively few economic evaluations of population salt reduction interventions. None of the studies were based on actual implementation of intervention(s) and the associated collection of new empirical data. The studies universally showed that population-based salt reduction strategies are likely to be cost effective or cost saving. However, given the reliance on modelling, there is a need for the effectiveness of new interventions to be evaluated in the field using strong study designs and parallel economic evaluations.
Occupational Safety and Response Maintenance

Abstract I commend Boyce and Geller's concern for one of the most important and most ignored areas of application in behavior analysis -highway and occupational safety. And I commend their concern for one of the most important and most ignored areas of theory and technology -performance maintenance. My critical comments reflect my additional concerns -concerns about the unspoken values, attitudes, and theoretical biases I think underlie much of the applied work in behavior analysis, and may also underlie much of the empirical research and theoretical analysis presented in Boyce and Geller's excellent article. Here are those additional concerns: a. (a) (the cult of the natural contingency b. (b) the error of naïve performance management c. (c) the myth of intermittent reinforcement d. (d) the obfuscation approach to performance maintenance e. (e) the mythical cause of poor self-management f. (f) the nature of effective performance-management contingencies g. (g) the limitations of say-do commitment h. the failure to distinguish between the direct-acting behavioral contingencies of the Skinner box and the indirect-acting, rule-governed, analog contingencies of most applied behavior analysis i. the fear of aversive control j. the myth of perpetual-behavior interventions.
Membrane Potential and Firing Rate in Cat Primary Visual Cortex

We have investigated the relationship between membrane potential and firing rate in cat visual cortex and found that the spike threshold contributes substantially to the sharpness of orientation tuning. The half-width at half-height of the tuning of the spike responses was 23 ± 8°, compared with 38 ± 15° for the membrane potential responses. Direction selectivity was also greater in spike responses (direction index, 0.61 ± 0.35) than in membrane potential responses (0.28 ± 0.21). Threshold also increased the distinction between simple and complex cells, which is commonly based on the linearity of the spike responses to drifting sinusoidal gratings. In many simple cells, such stimuli evoked substantial elevations in the mean potential, which are nonlinear. Being subthreshold, these elevations would be hard to detect in the firing rate responses. Moreover, just as simple cells displayed various degrees of nonlinearity, complex cells displayed various degrees of linearity. We fitted the firing rates with a classic rectification model in which firing rate is zero at potentials below a threshold and grows linearly with the potential above threshold. When the model was applied to a low-pass-filtered version of the membrane potential (with spikes removed), the estimated values of threshold (−54.4 ± 1.4 mV) and linear gain (7.2 ± 0.6 spikes · sec−1 · mV−1) were similar across the population. The predicted firing rates matched the observed firing rates well and accounted for the sharpening of orientation tuning of the spike responses relative to that of the membrane potential. As it was for stimulus orientation, threshold was also independent of stimulus contrast. The rectification model accounted for the dependence of spike responses on contrast and, because of a stimulus-induced tonic hyperpolarization, for the response adaptation induced by prolonged stimulation. Because gain and threshold are unaffected by visual stimulation and by adaptation, we suggest that they are constant under all conditions.
Time pressured deprioritization of COPD in primary care: a qualitative study

Abstract Objective: To identify factors that hinder discussions regarding chronic obstructive pulmonary disease (COPD) between primary care physicians (PCPs) and their patients in Sweden. Setting: Primary health care centres (PHCCs) in Stockholm, Sweden. Subjects: A total of 59 PCPs. Design: Semi-structured individual and focus-group interviews between 2012 and 2014. Data were analysed inspired by grounded theory methods (GTM). Results: Time-pressured patient–doctor consultations lead to deprioritization of COPD. During unscheduled visits, deprioritization resulted from focusing only on acute health concerns, while during routine care visits, COPD was deprioritized in multi-morbid patients. The reasons PCPs gave for deprioritizing COPD are: “Not becoming aware of COPD”, “Not becoming concerned due to clinical features”, “Insufficient local routines for COPD care”, “Negative personal attitudes and views about COPD”, “Managing diagnoses one at a time”, and “Perceiving a patient’s motivation as low’’. Conclusions: De-prioritization of COPD was discovered during PCP consultations and several factors were identified associated with time constraints and multi-morbidity. A holistic consultation approach is suggested, plus extended consultation time for multi-morbid patients, and better documentation and local routines. Key points Under-diagnosis and insufficient management of chronic obstructive pulmonary disease (COPD) are common in primary health care. A patient–doctor consultation offers a key opportunity to identify and provide COPD care. Time pressure, due to either high number of patients or multi-morbidity, leads to omission or deprioritization of COPD during consultation. Deprioritization occurs due to lack of awareness, concern, and local routines, negative personal views, non-holistic consultation approach, and low patient motivation. Better local routines, extended consultation time, and a holistic approach are needed when managing multi-morbid patients with COPD.
Bladder neck preservation improves time to continence after radical prostatectomy: a systematic review and meta-analysis

Bladder neck preservation (BNP) during radical prostatectomy (RP) may improve postoperative urinary continence, although its overall effectiveness remains controversial. We systematically searched PubMed, Ovid Medline, Embase, CBM and the Cochrane Library to identify studies published before February 2016 that assessed associations between BNP and post-RP urinary continence. Thirteen trials (1130 cases and 1154 controls) assessing BNP versus noBNP (or with bladder neck reconstruction, BNR) were considered suitable for meta-analysis, including two randomized controlled trials (RCT), six prospective and five retrospective studies. Meta-analysis demonstrated that BNP improved early urinary continence rates (6 mo, OR = 1.66; 95% CI, 1.21–2.27; P = 0.001) and long-term urinary continence outcomes (>12 mo, OR = 3.99; 95% CI, 1.94–8.21; P = 0.0002). Patients with BNP also had lower bladder neck stricture frequencies (OR = 0.49; 95% CI, 0.29–0.81; P = 0.006). Anastomotic leak rates, positive surgical margins and biochemical failure rates were comparable between the two groups (P>0.05). There were no differences in baseline characteristics except for a smaller average prostate volume (WMD = −2.24 ml; 95% CI, -4.27 to -0.22; P = 0.03) in BNP patients. Our analyses indicated that BNP during RP improved early recovery and overall long-term (1 year) urinary continence and decreased bladder neck stricture rates without compromising oncologic control.
Epidemiological, clinical and histopathologic characteristics of celiac disease: Results of a case-finding population-based program in an Italian community

Objective. Celiac disease (CD) is underdiagnosed mainly because of lack of awareness of its heterogeneous clinical presentation. The Center for Surveillance and Control of Celiac Disease (CCD) was set up in June 2000 in the province of Brescia, Northern Italy (1,016,426) inhabitants to enhance case-finding, to standardize diagnostic criteria and to collect epidemiological data. Material and methods. The CCD has prompted an educational “celiac awareness program” in the primary-care setting focusing on selective serological screening of high-risk groups, and has reviewed by standardized criteria all diagnoses made in the province since 1984. Results. A total of 1437 CD patients have been identified by the CCD, 508 of them diagnosed after June 2000 during the 3 years of activity of the Center (M:F 2:1). Annual incidence was 0.11/1000 before and increased to 0.17/1000 during CCD activity, and this increase was greater for adult (from 0.07/1000 to 0.12/1000) than for pediatric CD (from 0.04/1000 to 0.05/1000). Mean age at diagnosis also increased from 20.2±17.7 years to 27.2±19.3 years (p<0.0001) as did the proportion of asymptomatic patients (8% versus 15%) before and during CCD activity. There was a linear trend towards increasing proportions of symptomatic patients with increasing severity of histopathologic lesions (p<0.03). Conclusions. Our results indicate that educational programs promoting serological screening of CD in high-risk groups are effective for case-finding in large communities, particularly among the adult population, and suggest that primary-care doctors caring for adults should be particularly targeted by “celiac awareness programs”.
Targeted therapy for Hodgkin lymphoma and systemic anaplastic large cell lymphoma: focus on brentuximab vedotin

Despite the relative success of chemotherapy for Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (ALCL), novel therapeutic agents are needed for refractory or relapsed patients. Targeted immunotherapy has emerged as a novel treatment option for these patients. Although unconjugated anti-cluster of differentiation (CD)30 antibodies showed minimal antitumor activity in early clinical trials, development of antibody–drug conjugates (ADCs) appears promising. Brentuximab vedotin is an ADC composed of an anti-CD30 antibody linked to a potent microtubule-disrupting agent monomethyl auristatin E (MMAE). It has the ability to target CD30-positive tumor cells and, once bound to CD30, brentuximab vedotin is internalized and MMAE is released to induce cell cycle arrest and apoptosis. In two Phase II trials, objective response was reported in 75% and 86% of patients with refractory or relapsed HL and systemic ALCL, respectively, with an acceptable toxicity profile. Based on these studies, the US Food and Drug Administration (FDA) granted accelerated approval of brentuximab vedotin in August 2011 for the treatment of refractory and relapsed HL and ALCL. We review the key characteristics of brentuximab vedotin, clinical data supporting its therapeutic efficacy, and current ongoing trials to explore its utility in other CD30-positive malignancies.
After 9/11 at Ground Zero: The Anxiety-Buffering Effects of Worldview Support on the First Anniversary of 9/11

A field experiment adjacent to the former World Trade Center in New York City on the anniversary of the 9/11 terrorist attacks examined the prediction of terror management theory (TMT; Greenberg, Pyszcznyski, & Solomon, 1986) that individuals validate their cultural beliefs when exposed to subtle rather than overt death reminders. Participants (N = 410) who were exposed to a subtle reminder of 9/11 perceived more social consensus for their belief than those who were exposed to an overt one. Consistent with TMT, the pattern was especially strong for participants with the minority belief. The effect abated once the anniversary ended. The implications of this research and future directions are discussed.
The Individual-Oriented and Social-Oriented Chinese Bicultural Self: Testing the Theory

The author proposes a bicultural self theory for contemporary Chinese individuals, encompassing 2 main components: the individual-oriented self and the social-oriented self. The social orientation is rooted in traditional Chinese conceptualization of the self, whereas the individual orientation has evolved and developed under Western influences along with recent societal modernization. The author conducted a series of 5 studies to test the theory and relate the model to important issues in current personality and social psychological research, such as cultural individualism-collectivism, self-construals, motivation, cognition, emotion, and well-being. A total of 977 university students in Taiwan participated. The author found that contrasting self-aspects were differentially associated with the aforementioned constructs, as theoretically predicted. This evidence thus generally supported the bicultural self model.
Particle size design of PLGA microspheres for potential pulmonary drug delivery using response surface methodology

Abstract The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium are unique features of the lung facilitating systemic drug delivery via pulmonary administration. The efficacy and safety of many new and existing inhaled therapies may be enhanced through advanced controlled-release systems by using polymer particles. Poly (D,L-lactic-co-glycolic acid) (PLGA) is well known by its safety in biomedical preparations which has been approved for human use by the FDA. The optimum aerodynamic particle size distribution for most inhalation aerosols has generally been recognized to be in the range of 1–5 microns. PLGA microspheres, therefore, were prepared by a developed oil-in-oil solvent evaporation method and characterized. A four-factor, three levels Box-Behnken design was used for the optimization procedure with temperature, stirring speed, PLGA and surfactant concentration as independent variables. Particle size and polydispersity of microspheres were considered as dependent variables. PLGA microparticles were prepared successfully in desired size for pulmonary delivery by solvent evaporation method. It was found that the particle size of microspheres could be easily controlled. It was also proved that response surface methodology could efficiently be applied for size characterization and optimization of PLGA microparticles for pulmonary drug delivery.
Getting to the heart of leadership: emotion and educational leadership

The collective task of understanding and developing leadership within an organisation being undertaken by those interested in organisational management and advocating views of distributed leadership is set against those in which the development of self as leader is advocated. In their transformational view of leadership, Kouzes and Posner assert that ‘leadership development is selfdevelopment . the instrument of leadership is the self and mastery of the art of leadership comes from the mastery of the self’ (Kouzes and Posner 2002, 390). This book contributes to our understanding of the emotional burden of this journey of self-discovery with respect to better understanding the inhabitation of the role of head teachers. As an application of Gardner’s work on multiple intelligences, emotional intelligence has been highlighted as the key focus for leaders in thinking about their effectiveness (Goleman 1995, 1996; McWilliam and Hacker 2007) such that they work towards exhibiting ‘appropriate’ emotion (Goleman 1996, 56). Studying the ‘emotional journeys’ of head teachers in an explication of the affective dimension to their work, and distinguishing between ‘feelings (what we experience internally), emotions (feelings that we show) and moods (feelings that persist over time)’ (8), this work focuses mainly on the expressed emotions. The book is laid out such that the terrain of emotion and leadership is explored in Chapters 1 and 2, illustrated with data from the project, followed by, in Chapter 3, an exploration of how narratives were collected to reveal emotions. Eleven head teachers were interviewed from both primary and secondary schools, male and female, and aged between 42 and 55. The stories of three of these head teachers are presented in detail in Chapter 4. The social dimension to the emotional burden of their work as head teachers forms the basis of Chapter 5, in which data from some of the other head teachers is included. Pivotal emotional events pulled out as significant by the head teachers themselves are drawn upon in Chapter 6 to allow the context of each event to be taken into account. The book concludes by first summarising what it means to be a head teacher in a school today, in terms of the social and personal aspects to this (in Chapter 7) and then, in Chapter 8, identifying elements of context and policy in the future that may affect the emotional terrain for head teachers. Each chapter offers suggestions for questions that could guide further thought on the issues raised and there is a list of further reading annotated with the particular value of each article or book. This book offers a readily accessible response to the technical-rational view of managerial leadership being advocated, highlighting the importance of individualising rather than normalising views of leadership, termed by McDermott (1994) as ‘leadership from within’. As with Antonacopoulou and Bento (2004), Crawford sees this as relating to two principles: leadership as a window to inner learning and as a The Curriculum Journal Vol. 20, No. 3, September 2009, 310–311
The tap‐tpg gene pair on the linear plasmid functions to maintain a linear topology of the chromosome in Streptomyces rochei

Streptomyces rochei 7434AN4 carries three linear plasmids, pSLA2‐L (211 kb), pSLA2‐M (113 kb) and pSLA2‐S (18 kb), their complete nucleotide sequences having been determined. Restriction and sequencing analysis revealed that the telomere sequences at both ends of the linear chromosome are identical to each other, are 98.5% identical to the right end sequences of pSLA2‐L and pSLA2‐M up to 3.1 kb from the ends and have homology to those of typical Streptomyces species. Mutant 2‐39, which lost all the three linear plasmids, was found to carry a circularized chromosome. Sequence comparison of the fusion junction and both deletion ends revealed that chromosomal circularization occurred by terminal deletions followed by nonhomologous recombination. Curing of pSLA2‐L from strain 51252, which carries only pSLA2‐L, also resulted in terminal deletions in newly obtained mutants. The tap‐tpg gene pair, which encodes a telomere‐associated protein and a terminal protein for end patching, is located on pSLA2‐L and pSLA2–M but has not hitherto been found on the chromosome. These results led us to the idea that the tap‐tpg of pSLA2‐L or pSLA2‐M functions to maintain a linear chromosome in strain 7434AN4. This hypothesis was finally confirmed by complementation and curing experiments of the tap‐tpg of pSLA2‐M.
Leveraging Auxiliary Data for Learning to Rank

In learning to rank, both the quality and quantity of the training data have significant impacts on the performance of the learned ranking functions. However, in many applications, there are usually not sufficient labeled training data for the construction of an accurate ranking model. It is therefore desirable to leverage existing training data from other tasks when learning the ranking function for a particular task, an important problem which we tackle in this article utilizing a boosting framework with transfer learning. In particular, we propose to adaptively learn transferable representations called super-features from the training data of both the target task and the auxiliary task. Those super-features and the coefficients for combining them are learned in an iterative stage-wise fashion. Unlike previous transfer learning methods, the super-features can be adaptively learned by weak learners from the data. Therefore, the proposed framework is sufficiently flexible to deal with complicated common structures among different learning tasks. We evaluate the performance of the proposed transfer learning method for two datasets from the Letor collection and one dataset collected from a commercial search engine, and we also compare our methods with several existing transfer learning methods. Our results demonstrate that the proposed method can enhance the ranking functions of the target tasks utilizing the training data from the auxiliary tasks.