Miracle-dz/UniFAR-FTUs huggingface dataset:
CRN2 enhances the invasiveness of glioblastoma cells

Abstract Background Movement of tumor cells involves dynamic remodeling of the actin cytoskeleton, which is regulated by actin binding proteins, such as CRN2 (synonyms: coronin 1C, coronin 3). In vitro, CRN2 participates in secretion, matrix degradation, protrusion formation, and cell migration. Furthermore, expression of CRN2 correlates with the malignant phenotype of human diffuse gliomas. CRN2's effects on actin polymerization and F-actin bundling are abolished by protein kinase 2 (CK2) dependent phosphorylation at serine 463. Methods We generated human U373 glioblastoma cell lines with knock-down of CRN2 or over-expression of CRN2 variants and studied their behavior in vitro and ex vivo in organotypic brain slice cultures. Results CRN2 over-expression and expression of the S463A phospho-resistant CRN2 variant increase proliferation, matrix degradation, and invasion but decrease adhesion and formation of invadopodia-like extensions in vitro. Knock-down of CRN2 and expression of S463D phospho-mimetic CRN2 generally have opposite effects. Analysis of invadopodia-like cell extensions shows a diffuse relocalization of F-actin in CRN2 knockdown cells, whereas expression of S463A and S463D mutant CRN2 causes enrichments of F-actin structures at the center and rime zone, respectively. Fluorescence recovery after photobleaching studies of CRN2 and F-actin in lamellipodia show that both CRN2 variants decrease the turnover of actin filaments. Glioblastoma cells over-expressing wild-type or S463A CRN2, which were transplanted onto brain slices, characteristically developed into tumors with an invasive phenotype. Conclusions Overall, our data indicate that CRN2 participates in cancer progression via modulation of the actin cytoskeleton.
Adaptive Associations between Social Cognition and Emotion Regulation are Absent in Schizophrenia and Bipolar Disorder

Schizophrenia (SZ) and bipolar disorder (BD) are associated with impairments in facial emotion perception and Theory of Mind (ToM). These social cognitive skills deficits may be related to a reduced capacity to effectively regulate one’s own emotions according to the social context. We therefore set out to examine the relationship between social cognitive abilities and the use of cognitive strategies for regulating negative emotion in SZ and BD. Participants were 56 SZ, 33 BD, and 58 healthy controls (HC) who completed the Ekman 60-faces test of facial emotion recognition; a sub-set of these participants also completed The Awareness of Social Inference Test (TASIT) and the Cognitive Emotion Regulation Questionnaire (CERQ). SZ participants demonstrated impairments in emotion perception on both the Ekman and the TASIT Emotion Evaluation tests relative to BD and HC. While both SZ and BD patients showed ToM deficits (i.e., perception of sarcasm and lie) compared to HC, SZ patients demonstrated significantly greater ToM impairment compared to BD. There were also distinct patterns of cognitive strategies used to regulate emotion in both patient groups: those with SZ were more likely to engage in catastrophizing and rumination, while BD subjects were more likely to blame themselves and were less likely to engage in positive reappraisal, relative to HC. In addition, those with SZ were more likely to blame others compared to BD. Associations between social cognition and affect regulation were revealed for HC only: TASIT performance was negatively associated with more frequent use of rumination, catastrophizing, and blaming others, such that more frequent use of maladaptive cognitive emotion regulation strategies was associated with poor social cognitive performance. These associations were not present in either patient group. However, both SZ and BD patients demonstrated poor ToM performance and aberrant use of emotion regulation strategies consistent with previous studies. SZ also showed basic emotion recognition deficits relative to BD and HC. That there were no associations between social cognition and the capacity to self-regulate negative emotion in SZ and BD (in the context of poor social cognition and maladaptive regulatory strategies) suggests that dysfunction in fronto-limbic brain networks may underpin both social cognitive deficits and the use of maladaptive cognitive strategies in these disorders, albeit by potentially different routes.
Cross-Breeding Is Inevitable to Conserve the Highly Inbred Population of Puffin Hunter: The Norwegian Lundehund

The Norwegian Lundehund is a highly endangered native dog breed. Low fertility and high frequency predisposition to intestinal disorder imply inbreeding depression. We assessed the genetic diversity of the Lundehund population from pedigree data and evaluated the potential of optimal contribution selection and cross-breeding in the long-term management of the Lundehund population. The current Norwegian Lundehund population is highly inbred and has lost 38.8% of the genetic diversity in the base population. Effective population size estimates varied between 13 and 82 depending on the method used. Optimal contribution selection alone facilitates no improvement in the current situation in the Lundehund due to the extremely high relatedness of the whole population. Addition of (replacement with) 10 breeding candidates of foreign breed to 30 Lundehund breeders reduced the parental additive genetic relationship by 40–42% (48–53%). Immediate actions are needed to increase the genetic diversity in the current Lundehund population. The only option to secure the conservation of this rare breed is to introduce individuals from foreign breeds as breeding candidates.
Observational determination of the time delays in gravitational lens system Q2237+0305

We present new brightness monitoring observations of the 4 components of gravitationally lensed system Q2237+0305, which show detection of an intrinsic quasar brightness fluctuation at a time of subdued microlensing activity, between June 27 and October 12, 2003. These data were used to determine the time delays between the arrivals of the four images. The measured delays are τ BA -6, τ CA 35, and τ DA 2 h, so they confirm that the long history of brightness monitoring has produced significant detection of microlensing. However the error bars associated with the delays, of order 2 days, are too large to discriminate between competing macro-imaging models. Moreover, our simulations show that for the amplitude of this intrinsic fluctuation and for photometric errors intrinsic to optical monitoring from our 1.5-m telescope or from the OGLE monitoring, a daily sampled brightness record cannot produce reliable lags for model discrimination. We use our simulations to devise a strategy for future delay determination with optical data. Nevertheless, we regard these first estimates to be significant, since they are the first direct measurements of time delays made for this system from ground-based observations in the visual wavelengths. The detected highly correlated fluctuations of the four quasar images provide an extra confirmation of the gravitational-lens nature of Q2237+0305, and give observational justification to the extensive literature which attributes the quasar's previously observed brightness fluctuations to microlensing.
The recycling of gas and metals in galaxy formation: predictions of a dynamical feedback model

We present results of a new feedback scheme implemented in the Munich galaxy formation model. The new scheme includes a dynamical treatment of galactic winds powered by supernova explosions and stellar winds in a cosmological context. We find that such a scheme is a good alternative to empirically motivated recipes for feedback in galaxy formation. Model results are in good agreement with the observed luminosity functions and stellar mass function for galaxies in the local universe. In particular, the new scheme predicts a number density of dwarfs that is lower than in previous models. This is a consequence of a new feature of the model, which allows an estimate of the amount of mass and metals that haloes can permanently deposit into the intergalactic medium (IGM). This loss of material leads to the suppression of star formation in small haloes and therefore to the decrease in the number density of dwarf galaxies. The model is able to reproduce the observed mass‐stellar metallicity and luminosity‐gas metallicity relationships. This demonstrates that our scheme provides a significant improvement in the treatment of the feedback in dwarf galaxies. Despite these successes, our model does not reproduce the observed bimodality in galaxy colours and predicts a larger number of bright galaxies than observed. Finally, we investigate the efficiency of metal injection in winds and in the IGM. We find that galaxies that reside in haloes with Mvir < 1
The instructional effects of diagrams and time-compressed instruction on student achievement and learners' perceptions of cognitive load

The purpose of this study was to examine the effects of visual representations and time-compressed instruction on learning and learners’ perceptions of cognitive load. Time-compressed instruction refers to instruction that has been increased in speed without sacrificing quality. It was anticipated that learners would be able to gain a conceptual understanding of technical material at normal and moderately compressed (25%) speeds while instruction presented at 50% compression would depresses it. Visual representations (images/diagrams) have been shown to support learning from a multimedia environment when presented with verbal representations. Thus, it was anticipated that visuals would support learning in a time-compressed environment. This study employed 216 undergraduate students from a medium sized university in a 2x3 factorial design. The independent variables were visuals (visual, no-visual) and compression rates (0%, 25%, 50%). Participants listened to audio instruction of the heart and those in the visuals condition also viewed 19 diagrams that corresponded to the verbal instruction. The dependent variables consisted of four achievement tests: drawing, identification, terminology, and comprehension. Total test, Review Behaviors (back and replay buttons), time-on-task, and perceptions of cognitive load served as additional dependent variables. Prior knowledge of biology was also measured and considered for use as a covariate. Overall, scores on the knowledge-based posttest measures indicate that learning is not significantly affected at the 25% rate, but it is depressed at the 50% compression rate. Participants who listened to compressed instruction at the 50% rate obtained lower scores on the total, drawing, and identification tests than did those in who listened to either
Epidemiologic variables and outcome of 1972 young patients with acute myocardial infarction. Data from the GISSI-2 database. Investigators of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-2).

BACKGROUND Acute myocardial infarction in younger patients is uncommon, occurring mainly in men. The recent introduction of thrombolysis improved survival, left ventricular function, and infarct size. OBJECTIVE To evaluate characteristics and clinical outcome of the patients younger than 50 years randomized in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico study. All patients received a thrombolytic treatment. METHODS The 11483 patients were divided into 3 age subgroups: younger than 50 years (17.2%), between 50 and 70 years (60.2%), and older than 70 years (22.6%). All relations between variables were first determined by an unadjusted analysis. An adjusted analysis was performed by multiple logistic regression models for in-hospital and 6-month mortality. RESULTS While older patients had a significantly higher rate of a history of hypercholesterolemia, diabetes, and hypertension, smoking and a positive family history were significantly more frequent in younger patients. Total in-hospital and 6-month mortality were significantly lower in patients younger than 50 years (2.7% and 1.2%, respectively) than in patients between 50 and 70 years old (6.9% and 2.7%) and those older than 70 years (21.1% and 8.4%). After multivariate analysis, the predictive value of age was confirmed. CONCLUSIONS Our findings, based on a large group of patients who received thrombolytic treatment, suggest that younger age is a significant independent indicator of a favorable prognosis after acute myocardial infarction.
Software Engineering Solutions for Improving the Regression Testing Methods in Scientific Applications Development

regression testing is essential. Concerning to improve the methods of regression testing the relationship between requirements and test case selection for regression testing is included as a relevant for improving the overall quality of the testing process. Special emphasis is given on the requirements’ changes during the application development process and their impact on test case modications. In addition, we also state the reasons for the implementation and the importance of the regression testing as a part of the verication process of scientic applications. In order to get more relevant results we made an interview with a scientist (chemist) about the regression testing practices in scientic applications. The conclusions and recommendations in this paper are based on the analysis of the results of a survey conducted among scientists in the HP-SEE project and the answers of the interview questions.
The Landscape of Fear: Ecological Implications of Being Afraid~!2009-09-09~!2009-11-16~!2010-02-02~!

Predation risk" and "fear" are concepts well established in animal behavior literature. We expand these concepts to develop the model of the "landscape of fear". The landscape of fear represents relative levels of predation risk as peaks and valleys that reflect the level of fear of predation a prey experiences in different parts of its area of use. We provide observations in support of this model regarding changes in predation risk with respect to habitat types, and terrain characteristics. We postulate that animals have the ability to learn and can respond to differing levels of predation risk. We propose that the landscape of fear can be quantified with the use of well documented existing methods such as giving- up densities, vigilance observations, and foraging surveys of plants. We conclude that the landscape of fear is a useful visual model and has the potential to become a unifying ecological concept.
Steroid receptors in pleural effusions of advanced breast cancer patients

The steroid receptor content in breast carcinoma correlates with the responsiveness of malignant cells to endocrine manipulation. Although the steroid receptor status of the primary tumor is mostly used to select systemic therapy, it was suggested that steroid receptor content should be evaluated in metastatic lesions whenever possible. In this study the estrogen and progesterone receptor content was determined biochemically in 38 pleural effusions from advanced breast cancer patients. In 17/38 patients the steroid receptor status was assessed twice during the course of the disease - at diagnosis in the primary tumor/lymph nodes, and subsequently in metastatic pleural effusion fluid. A trend towards lower receptor values in pleural fluids was evident. There was no correlation between pleural steroid receptor content and pleural response to endocrine or chemo/endocrine therapy, indicating that the usefulness of effusional steroid receptors for therapy planning of advanced breast cancer could not be confirmed in this study.
“I Feel Contaminated in My Fake Hand”: Obsessive-Compulsive-Disorder like Disgust Sensations Arise from Dummy during Rubber Hand Illusion

Despite its theoretical and clinical interest, there are no experimental studies exploring obsessive-compulsive disorder (OCD)-like disgust sensations through using somatosensory illusions. Such illusions provide important clues to the nature and limits of multisensory integration and how the brain constructs body image; and may potentially inform novel therapies. One such effect is the rubber hand illusion (RHI) in which tactile sensations are referred to a rubber hand; if the experimenter simultaneously strokes a subject’s occluded hand together with a visible fake hand, the subject starts experiencing the touch sensations as arising from the dummy. In this study, we explore whether OCD-like disgust may result from contamination of a dummy hand during the RHI; suggesting a possible integration of somatosensory and limbic inputs in the construction of body image. We predicted that participants would experience sensations of disgust, when placing a disgust stimulus (fake feces, vomit or blood) on the dummy hand after establishing the RHI. We found that 9 out of 11 participants experienced greater disgust during the synchronous condition (real hidden hand and fake hand are stroked in synchrony) compared to the asynchronous control condition (real hidden hand and fake hand are stroked in asynchrony); and on average such disgust was significantly greater during the synchronous condition compared to the asynchronous control condition, Z = 2.7, p = . 008. These results argue against a strictly hierarchical modular approach to brain function and suggest that a four-way multisensory interaction occurs between vision, touch, proprioception on the one hand and primal emotions like disgust on the other. These findings may inform novel clinical approaches for OCD; that is, contaminating a dummy during the RHI could possibly be used as part of an in-vivo exposure-intervention for OCD.
International Journal of Applied Earth Observation and Geoinformation

Leaf area index (LAI) and biomass are important indicators of crop development and the availability of this information during the growing season can support farmer decision making processes. This study demonstrates the applicability of RapidEye multi-spectral data for estimation of LAI and biomass of two crop types (corn and soybean) with different canopy structure, leaf structure and photosynthetic pathways. The advantages of Rapid Eye in terms of increased temporal resolution ( ∼ daily), high spatial resolution ( ∼ 5 m) and enhanced spectral information (includes red-edge band) are explored as an individual sensor and as part of a multi-sensor constellation. Seven vegetation indices based on combinations of reﬂectance in green, red, red-edge and near infrared bands were derived from RapidEye imagery between 2011 and 2013. LAI and biomass data were collected during the same period for calibration and validation of the relationships between vegetation indices and LAI and dry above-ground biomass. Most indices showed sensitivity to LAI from emergence to 8 m 2 /m 2 . The normalized difference vegetation index (NDVI), the red-edge NDVI and the green NDVI were insensitive to crop type and had coefﬁcients of variations (CV) ranging between 19 and 27%; and coefﬁcients of determination ranging between 86 and 88%. The NDVI performed best for the estimation of dry leaf biomass (CV = 27% and r 2 = 090) and was also insensitive to crop type. The red-edge indices did not show any signiﬁcant improvement in LAI and biomass estimation over traditional multispectral indices. Cumulative vegetation indices showed strong performance for estimation of total dry above-ground biomass, especially for corn (CV ≤ 20%). This study demonstrated that continuous crop LAI monitoring over time and space at the ﬁeld level can be achieved using a combination of RapidEye, Landsat and SPOT data and sensor-dependant best-ﬁt functions. This approach eliminates/reduces the need for reﬂectance resampling, VIs inter-calibration and spatial resampling.
Quantum mechanics as a macrorealistic theory

As contrasted with physicists to idolize Bell's theorem and quantum nonlocality, we argue that quantum mechanics (QM), in reality, respects the principles of a macroscopic realism (PMRs). The current QM to tell us that ". the state of a system can be instantaneously changed by a distant measurement >. " cannot be treated as a physical theory. Its key statements - that the EPR-Bell experiments to violate Bell's inequality verify nonlocality, and nonlocal correlations respect special relativity - are false. Both the EPR-Bell experiments and theorems to support the "non-signalling principle" are based on the implicit assumption that all quantum postulates and, in particular, Born's averaging rule are fully applicable to Cat states. However, this is not the case. Introducing observables (e.g., correlations) for Cat states violates the correspondence principle. Pure (macro- and micro-)Cat states must be governed both by the PMRs and superposition principle. Our (macrorealistic) model of a one-dimensional completed scattering shows how these principles coexist with each other, in the case of a one-electron micro-Cat state.
BENEFITS AND DRAWBACKS OF CONTROLLED LABORATORY STUDIES OF SECOND LANGUAGE ACQUISITION

A consistent finding in second language acquisition research has been that in the early stages of acquisition learners often receive simplified input. This finding has led researchers to question whether or not simplified input has a facilitative effect on the acquisition process. This study examines the effects of simplified input in early L2 acquisition by experimentally manipulating language input to two groups of learners and then assessing their acquisition longitudinally within a controlled laboratory setting. The impetus for the study described here was Givón's (1990) competition hypothesis that posits that, in early L2 acquisition, vocabulary and grammar compete for memory, attention, and processing capacity. Because one can communicate with vocabulary in absence of grammar but not vice versa, it was proposed that learners receiving pidgin input would acquire vocabulary more efficiently than learners challenged with the dual task of acquiring vocabulary and grammar simultaneously. Furthermore, it was hypothesized that once vocabulary processing skills were automated, learners would acquire grammar more rapidly. Results of a variety of measures reveal that the dual task of acquiring vocabulary and grammar does not hinder either and that the longer the exposure to grammatical input the greater the advantage in real-time grammar processing abilities. Converging evidence from all measures of language learning provides strong support for the usefulness and viability of laboratory study of SLA.
Hypnosis is More Effective than Clinical Interviews

Abstract To determine whether hypnosis is more effective than conventional interviewing to find traumatic life events in patients with fibromyalgia, we carried out a within-subject experimental design with complete intragroup counterbalancing. Thirty-two women under care in a public primary care center gave 2 identical interviews, with an interval of 3 months, in which the occurrence of traumatic life events was explored, once in a state of wakefulness and once in a state of hypnosis. The state of consciousness was evaluated using 3 measures: bispectral index, skin conductance level, and pain intensity. In the hypnotic state, the patients expressed 9.8 times more traumatic life events than in the waking state, a statistically significant difference with a large effect size.