Miracle-dz/UniFAR-FTUs huggingface dataset:
Two-Year Caries Clinical Study of the Efficacy of Novel Dentifrices Containing 1.5% Arginine, an Insoluble Calcium Compound and 1,450 ppm Fluoride

A 2-year double-blind randomized three-treatment controlled parallel-group clinical study compared the anti-caries efficacy of two dentifrices containing 1.5% arginine, an insoluble calcium compound (di-calcium phosphate or calcium carbonate) and 1,450 ppm fluoride (F), as sodium monofluorophosphate, to a control dentifrice containing 1,450 ppm F, as sodium fluoride, in a silica base. The 6,000 participants were from Bangkok, Thailand and aged 6-12 years initially. They were instructed to brush twice daily, in the morning and evening, with their randomly assigned dentifrice. Three trained and calibrated dentists examined the children at baseline and after 1 and 2 years using the National Institute of Dental Research Diagnostic Procedures and Criteria. The number of decayed, missing and filled teeth (DMFT) and surfaces (DMFS) for the three study groups were very similar at baseline, with no statistically significant differences among groups. After 1 year, there were no statistically significant differences in caries increments among the three groups. After 2 years, the two groups using the dentifrices containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm F had statistically significantly (p < 0.02) lower DMFT increments (21.0 and 17.7% reductions, respectively) and DMFS increments (16.5 and 16.5%) compared to the control dentifrice. The differences between the two groups using the new dentifrices were not statistically significant. The results of this pivotal clinical study support the conclusion that dentifrices containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm F provide significantly greater protection against caries lesion cavitation, in a low to moderate caries risk population, than dentifrices containing 1,450 ppm F alone.
Small Marine Protected Areas in Fiji Provide Refuge for Reef Fish Assemblages, Feeding Groups, and Corals

The establishment of no-take marine protected areas (MPAs) on coral reefs is a common management strategy for conserving the diversity, abundance, and biomass of reef organisms. Generally, well-managed and enforced MPAs can increase or maintain the diversity and function of the enclosed coral reef, with some of the benefits extending to adjacent non-protected reefs. A fundamental question in coral reef conservation is whether these benefits arise within small MPAs (<1 km2), because larval input of reef organisms is largely decoupled from local adult reproduction. We examined the structure of fish assemblages, composition of fish feeding groups, benthic cover, and key ecosystem processes (grazing, macroalgal browsing, and coral replenishment) in three small (0.5–0.8 km2) no-take MPAs and adjacent areas where fisheries are allowed (non-MPAs) on coral reefs in Fiji. The MPAs exhibited greater species richness, density, and biomass of fishes than non-MPAs. Furthermore, MPAs contained a greater abundance and biomass of grazing herbivores and piscivores as well as a greater abundance of cleaners than fished areas. We also found differences in fish associations when foraging, with feeding groups being generally more diverse and having greater biomass within MPAs than adjacent non-MPAs. Grazing by parrotfishes was 3–6 times greater, and macroalgal browsing was 3–5 times greater in MPAs than in non-MPAs. On average, MPAs had 260–280% as much coral cover and only 5–25% as much macroalgal cover as their paired non-MPA sites. Finally, two of the three MPAs had three-fold more coral recruits than adjacent non-MPAs. The results of this study indicate that small MPAs benefit not only populations of reef fishes, but also enhance ecosystem processes that are critical to reef resilience within the MPAs.
The relationship between anthropometric characteristics with balance in non-athlete old females

The relationship between anthropometric characteristics with balance in non-Athlete old females was aims of this article. The current research is a quasi-experimental study. The research project is pretest posttest and application of independent variable. 150 questionnaires were distributed among old female volunteers and from the individuals who had the required conditions to participate in the study 36 individuals were chosen as the research sample. The examinees' balance was measured by the use of Berg Balance Scale (BBS) (measuring the balance function based on 14 items used in daily life). Descriptive statistics was used for calculating mean and standard deviation of age, height, and weight of examinees and also the achieved scores in BBS. Pearson's correlation coefficient was used to assess the correlations between the variables (Balance). The results showed, that there is significant and negative relationship between weight and balance rate. There is significant and negative relationship between height and balance rate of non-athlete old females. There isn't significant relationship between age and balance rate of non-athlete old females.
The Vertical Distribution and Kinematics of H i and Mass Models of the Galactic Disk

We present full modeling of tangent point emission of HI as seen in the 21 cm transition in the inner Galaxy ($R \simeq 3-8 \kpc$). The model used takes into account emission from a large path length along the line of sight, corresponding to an interval ($\Delta R$) of typically $\le 1 \kpc$ in galactic radius; and is parametrized by the scale height of the gas, the centroid in z, the rotation velocity and the velocity dispersion. These parameters are assumed to be constant over the interval $\Delta R$. This modeling is carried out for the 21 cm surveys of Weaver \& Williams(1974), Bania \& Lockman (1984), and Kerr et al. (1986) to measure these parameters. The terminal velocity values are found to be in good agreement with previous measurements. The velocity dispersion is constant with radius at the theoretically expected value of $9 \pm 1 \kms$. The Gaussian scale height of the HI layer increases with Galactocentric radius. The centroid of the layer deviates significantly from $z=0$. Apart from small local variations, the velocity dispersion $\sigma_v$, scale height $\sigma_z$ and the centroid $z_0$ show similar variations in the first and the fourth quadrants. On balancing the turbulent pressure support of the layer against the disk gravitational potential, we confirm that additional support is needed for the HI layer. The radial profile of the reduced midplane mass density is an exponential with a scale length of $3.3 \pm 0.3 \kpc$. This picture is consistent with a constant mass-to-light ratio of the disk, and extra pressure support for the HI layer which is constant with radius in the inner Galaxy.
Investing for Retirement: The Moderating Effect of Fund Assortment Size on the 1/N Heuristic

Does the number of funds offered in a defined contribution plan affect how many funds consumers choose to invest in or how they spread dollars across the funds they choose? Across three experiments and the analysis of defined contribution plan data, the authors explore these issues by examining investors' tendency to engage in the 1/n heuristic— that is, allocating their dollars evenly across all available investment options. The authors decompose this heuristic into its two underlying behavioral dimensions: the tendency to invest in all available funds (which they label “1/n#”) and the tendency to spread the invested dollars evenly across chosen funds (which they label “1/n$”). The authors argue that choosing from larger fund assortments taxes investors' cognitive resources, which leads to more simplified diversification strategies. They find that increasing the fund assortment size decreases the tendency to invest in all available funds (1/n#) but increases the tendency to spread the invested dollars evenly among the chosen alternatives (1/n$), provided that the number of funds chosen for investment allows for easy equal dollar allocations. The authors integrate their results with prior research regarding asset choice and allocation heuristics.
Vascular Health and Risk Management Dovepress Effect of Melatonin on Nocturnal Blood Pressure: Meta-analysis of Randomized Controlled Trials

Background: Patients with nocturnal hypertension are at higher risk for cardiovascular complications such as myocardial infarction and cerebrovascular insult. Published studies inconsistently reported decreases in nocturnal blood pressure with melatonin. Methods: A meta-analysis of the efficacy and safety of exogenous melatonin in ameliorating nocturnal blood pressure was performed using a random effects model of all studies fitting the inclusion criteria, with subgroup analysis of fast-release versus controlled-release preparations. Results: Seven trials (three of controlled-release and four of fast-release melatonin) with 221 participants were included. Meta-analysis of all seven studies did not reveal significant effects of melatonin versus placebo on nocturnal blood pressure. However, subgroup analysis revealed that controlled-release melatonin significantly reduced nocturnal blood pressure whereas fast-release melatonin had no effect. Systolic blood pressure decreased significantly with controlled-release melatonin (−6.
Effect of Mutation on Genetic Differentiation Among Nonequilibrium Populations

Abstract The usefulness of GST and similar measures of genetic differentiation has been questioned repeatedly because of their dependence on the amount of heterozygosity within populations, creating problems when comparing degrees of divergence at loci with different mutation rates. Although the effect of mutation on GST is expected to be small in the early phases of divergence, it is unclear for how long after separation from a common ancestral population that GST is largely unaffected by mutation and by the resulting effect on heterozygosity. We address this question through analysis of the recursion equations for gene identity under the infinite allele model of mutation, and derive conditions describing when the effect of mutation on GST can be ignored under mutation–migration–drift equilibrium conditions and during the preceding transition phase. An important result is that during the transition phase GST is not only affected by mutation, but also by the heterozygosity in the base population from which the subpopulations diverged. The effect of mutation on GST is significant from the very start of the divergence process when initial heterozygosity is low, whereas GST is only weakly affected by mutation in the early phases of differentiation when initial heterozygosity is high. Thus, differentiation following a severe bottleneck is strongly dependent on mutation. The standardized measure of differentiation, G′ST, suggested by Hedrick (2005), may be helpful when comparing amounts of divergence at loci with different mutation rates under steady-state conditions, provided that migration is very low. In many other situations the use of G′ST might be misleading, however, and its application should be exercised with caution.
Anxiety, Processing Efficiency, and Cognitive Performance New Developments from Attentional Control Theory

There have been many attempts to account theoretically for the effects of anxiety on cognitive performance. This article focuses on two theories based on insights from cognitive psychology. The more recent is the attentional control theory (Eysenck, Derakshan, Santos, & Calvo, 2007), which developed from the earlier processing efficiency theory (Eysenck & Calvo, 1992). Both theories assume there is a fundamental distinction between performance effectiveness (quality of performance) and processing efficiency (the relationship between performance effectiveness and use of processing resources), and that anxiety impairs processing efficiency more than perfor- mance effectiveness. Both theories also assume that anxiety impairs the efficiency of the central executive component of the working memory system. In addition, attentional control theory assumes that anxiety impairs the efficiency of two types of attentional control: (1) negative attentional control (involved in inhibiting attention to task-irrelevant stimuli); and (2) positive attentional control (involved in flexibly switching attention between and within tasks to maximize performance). Recent (including unpublished) research relevant to theoretical predictions from attentional control theory is discussed. In addition, future directions for theory and research in the area of anxiety and performance are presented.
Functional Compensation in the Ventromedial Prefrontal Cortex Improves Memory-Dependent Decisions in Older Adults

Everyday consumer choices frequently involve memory, as when we retrieve information about consumer products when making purchasing decisions. In this context, poor memory may affect decision quality, particularly in individuals with memory decline, such as older adults. However, age differences in choice behavior may be reduced if older adults can recruit additional neural resources that support task performance. Although such functional compensation is well documented in other cognitive domains, it is presently unclear whether it can support memory-guided decision making and, if so, which brain regions play a role in compensation. The current study engaged younger and older humans in a memory-dependent choice task in which pairs of consumer products from a popular online-shopping site were evaluated with different delays between the first and second product. Using functional imaging (fMRI), we found that the ventromedial prefrontal cortex (vmPFC) supports compensation as defined by three a priori criteria: (1) increased vmPFC activation was observed in older versus younger adults; (2) age-related increases in vmPFC activity were associated with increased retrieval demands; and (3) increased vmPFC activity was positively associated with performance in older adults—evidence of successful compensation. Extending these results, we observed evidence for compensation in connectivity between vmPFC and the dorsolateral PFC during memory-dependent choice. In contrast, we found no evidence for age differences in value-related processing or age-related compensation for choices without delayed retrieval. Together, these results converge on the conclusion that age-related decline in memory-dependent choice performance can be minimized via functional compensation in vmPFC.
A model of underground ridership during the severe outbreaks of the SARS epidemic in a modern city

The outbreaks of the severe acute respiratory syndrome (SARS) epidemic in 2003 resulted in unprecedented impacts on people's daily life. One of the most significant impacts to people is the risk of contacting SARS while engaging daily routine activity. In this work we use data from daily underground ridership in Taipei and daily reported SARS cases in Taiwan to model the dynamics of the public underground usage during the wax and wane of the SARS period. We found that for each reported SARS case there is an immediate loss of about 1200 underground ridership. These loss rates propagate to the following days with an e-folding decay time of about 28 days, reflecting the public perception on the risk of contacting SARS disease when travelling with the underground system. About 50% of daily ridership was lost during the peak of the 2003 SARS period, compared with the loss of 80% daily ridership during the closure of the underground system after Typhoon Nari, the loss of 50-70% ridership due to the closure of the governmental offices and schools during typhoon periods, and the loss of 60% daily ridership during Chinese New Year holidays.
Hypoplastic left heart syndrome: a review

Background. Hypoplastic left heart syndrome (HLHS) is an etiologically multifactorial congenital heart disease affecting one in 5,000 newborns. Thirty years ago there were no treatment options for this pathology and the natural course of the disease led to death, usually within the first weeks of life. Recently surgical palliative techniques have been developed allowing for a five-year survival in more than half the cases. Materials and methods. We reviewed literature available on HLHS, specifically its anatomy, embryology and pathophysiology, and treatment. The Pubmed and ClinicalKey databases were searched using the key words hypoplastic left heart syndrome, foetal aortic valvuloplasty, foetal septoplasty, Norwood procedure, bidirectional Glenn procedure, Fontan procedure, hybrid procedure. The relevant literature was reviewed and included in the article. We reported a case from Children’s Clinical University Hospital, Riga, to illustrate treatment tactics in Latvia. Results. There are three possible directions for therapy in newborns with HLHS: orthotopic heart transplantation, staged surgical palliation and palliative non-surgical treatment or comfort care. Another treatment mode – foetal therapy – has arisen. Staged palliation and full Fontan circulation is a temporary solution, however, the only means for survival until heart transplantation. Fifty to 70% of patients who have gone through all three stages of palliation live to the age of five years. Conclusions. The superior mode of treatment is not yet clear and the management must be based on each individual case, the experience of each clinic, as well as the financial aspects and will of the patient’s parents.
Quantitative and Qualitative Criteria for Assessing Endurance in Women over 60 Years of Age – Findings from a Pilot Study

Abstract Introduction. If it is to be effective, health training needs to be monitored based on regular and periodic assessment. The norms that have been proposed for standardised endurance tests for the 60-plus age group, particularly for women, still require evaluation. In light of the above, we have undertaken to design quantitative and qualitative criteria for assessing the level of endurance. Such criteria are urgently needed by persons working with this age group. Material and methods. We developed a quantitative and qualitative system for evaluating endurance based on Zatsiorky’s model, and we verified it in a group of 90 women aged over 60 years. We analysed data measured directly during a 2-km walk test. Results. We developed a set of quantitative and qualitative criteria for assessing endurance in women aged over 60 years based on the results of a 2-km walk test, measured on a scale ranging from 24:18 to 15:52 min:s. Conclusion. The pilot study has proven that a scale based on Zatsiorsky’s model can be an effective tool for assessing endurance in women aged over 60 years. We can thus recommend that it be widely used in practice. It is important to compare these results with the norms for the group in question and to establish comprehensive norms that could be useful for persons who organise physical activity for older adults.
Exploring the ATP-binding site of P2X receptors

P2X receptors are ATP-gated non-selective cation channels involved in many different physiological processes, such as synaptic transmission, inflammation, and neuropathic pain. They form homo- or heterotrimeric complexes and contain three ATP-binding sites in their extracellular domain. The recent determination of X-ray structures of a P2X receptor solved in two states, a resting closed state and an ATP-bound, open-channel state, has provided unprecedented information not only regarding the three-dimensional shape of the receptor, but also on putative conformational changes that couple ATP binding to channel opening. These data provide a structural template for interpreting the huge amount of functional, mutagenesis, and biochemical data collected during more than fifteen years. In particular, the interfacial location of the ATP binding site and ATP orientation have been successfully confirmed by these structural studies. It appears that ATP binds to inter-subunit cavities shaped like open jaws, whose tightening induces the opening of the ion channel. These structural data thus represent a firm basis for understanding the activation mechanism of P2X receptors.
Improved spectrum mobility using virtual reservation in collaborative cognitive radio networks

Cognitive radio technology would enable a set of secondary users (SU) to opportunistically use the spectrum licensed to a primary user (PU). On the appearance of this PU on a specific frequency band, any SU occupying this band should free it for PUs. Typically, SUs may collaborate to reduce the impact of cognitive users on the primary network and to improve the performance of the SUs. In this paper, we propose and analyze the performance of virtual reservation in collaborative cognitive networks. Virtual reservation is a novel link maintenance strategy that aims to maximize the throughput of the cognitive network through full spectrum utilization. Our performance evaluation shows significant improvements not only in the SUs blocking and forced termination probabilities but also in the throughput of cognitive users.
Different Relationship between hsp70 mRNA and hsp70 Levels in the Heat Shock Response of Two Salmonids with Dissimilar Temperature Preference

The heat shock response (HSR) refers to the rapid production of heat shock proteins (hsps) in response to a sudden increase in temperature. Its regulation by heat shock factors is a good example of how gene expression is transcriptionally regulated by environmental stresses. In contrast, little is known about post-transcriptional regulation of the response. The heat shock response is often used to characterize the temperature tolerance of species with the rationale that whenever the response sets on, a species is approaching its lethal temperature. It has commonly been considered that an increase in hsp mRNA gives an accurate indication that the same happens to the protein level, but this need not be the case. With climate change, understanding the effects of temperature on gene expression of especially polar organisms has become imperative to evaluate how both biodiversity and commercially important species respond, since temperature increases are expected to be largest in polar areas. Here we studied the HSR of two phylogenetically related Arctic species, which differ in their temperature tolerance with Arctic charr having lower maximally tolerated temperature than Atlantic salmon. Arctic charr acclimated to 15°C and exposed to 7°C temperature increase for 30 min showed both an increase in hsp70 mRNA and hsp70 whereas in salmon only hsp70 mRNA increased. Our results indicate that the temperature for transcriptional induction of hsp can be different from the one required for a measurable change in inducible hsp level. The species with lower temperature tolerance, Arctic charr, are experiencing temperature stress already at the higher acclimation temperature, 15°C, as their hsp70 mRNA and hsp70 levels were higher, and they grow less than fish at 8°C (whereas for salmon the opposite is true). Consequently, charr experience more drastic heat shock than salmon. Although further studies are needed to establish the temperature range and length of exposure where hsp mRNA and hsp level are disconnected, the observation suggests that by measuring both hsp mRNA and hsp level, one can evaluate if a species is approaching the higher end of its temperature tolerance, and thus evaluate the vulnerability of an organism to the challenges imposed by elevated water temperature.