Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression in Human Breast Cancer Cells Omega-3 Polyunsaturated Fatty Acids Regulate Syndecan-1

Human epidemiologic studies and animal model studies support a role for n-3 polyunsaturated fatty acids (n-3 PUFA) in prevention or inhibition of breast cancer. However, mechanisms for this protection remain unclear. Syndecan-1 is a heparan sulfate proteoglycan, expressed on the surface of mammary epithelial cells and known to regulate many biological processes, including cytoskeletal organization, growth factor signaling, and cell-cell adhesion. We studied effects of n-3 PUFA on syndecan-1 expression in human mammary cell lines. PUFA were delivered to cells by lowdensity lipoproteins (LDL) isolated from the plasma of monkeys fed diets enriched in fish oil (n-3 PUFA) or linoleic acid (n-6 PUFA). Proteoglycan synthesis was measured by incorporation of [S]-sodium sulfate. No effect of either LDL was observed in nontumorigenic MCF-10A cells, whereas in MCF-7 breast cancer cells, treatment with n-3–enriched LDL but not n-6–enriched LDL resulted in significantly greater synthesis of a proteoglycan identified by immunoprecipitation as syndecan-1. Using real-time reverse transcription-PCR (RT-PCR), it was shown that n-3–enriched LDL significantly increased the expression of syndecan-1 mRNA in a dosedependent manner and maximal effective time at 8 hours of treatment. The effect was mimicked by an agonist for peroxisome proliferator-activated receptor ; (PPAR;) and eliminated by the presence of PPAR; antagonist suggesting a role for PPAR; in syndecan enhancement. Our studies show that n-3 LDL modifies the production of syndecan-1 in human breast cancer cells and suggest that biological processes regulated by syndecan-1 may be modified through LDL delivery of n-3 PUFA. (Cancer Res 2005; 65(10): 4442-7)
Population Genetic Inference From Resequencing Data

This article is concerned with statistical modeling of shotgun resequencing data and the use of such data for population genetic inference. We model data produced by sequencing-by-synthesis technologies such as the Solexa, 454, and polymerase colony (polony) systems, whose use is becoming increasingly widespread. We show how such data can be used to estimate evolutionary parameters (mutation and recombination rates), despite the fact that the data do not necessarily provide complete or aligned sequence information. We also present two refinements of our methods: one that is more robust to sequencing errors and another that can be used when no reference genome is available.
Self-affirmation improves music performance among performers high on the impulsivity dimension of sensation seeking

In the light of evidence that self-affirmation can mitigate the negative effects of stress on outcomes, this study tested whether a self-affirmation manipulation could improve undergraduate students’ achievement in a formal musical performance examination. The study also investigated the association between impulsivity and music performance and explored whether impulsivity moderated any impact of self-affirmation on exam performance. At baseline, participants provided demographic information and completed the UPPS-P Impulsive Behaviour Scale (short-form), which assesses five dimensions of impulsivity (negative and positive urgency, lack of premeditation, lack of perseverance, and sensation seeking). In the subsequent 14 days, participants (n = 65) completed either a self-affirmation manipulation or a control task, before reading a message about the impact of practice on music performance. Music performance was formally assessed 14 days later. Sensation seeking was the only dimension of impulsivity associated with exam performance, with participants high in sensation seeking receiving lower grades. Critically, self-affirmation promoted better music performance among those high in sensation seeking. Self-affirmation may provide a useful intervention to augment the performance of musicians who would otherwise perform worse than their counterparts under formal evaluative circumstances, such as those high in sensation seeking.
Cedex Discussion Paper Series Signaling about Norms: Socialization under Strategic Uncertainty *

The focus for the Centre is research into individual and strategic decision-making using a combination of theoretical and experimental methods. On the theory side, members of the Centre investigate individual choice under uncertainty, cooperative and non-cooperative game theory, as well as theories of psychology, bounded rationality and evolutionary game theory. Members of the Centre have applied experimental methods in the fields of public economics, individual choice under risk and uncertainty, strategic interaction, and the performance of auctions, markets and other economic institutions. Much of the Centre's research involves collaborative projects with researchers from other departments in the UK and overseas. Abstract We consider a society with informed individuals (adults) and naive individuals (children). Adults are altruistic towards their own children and possess information that allows to better predict the behavior of other adults. Children benefit from adopting behaviors that conform to the social norm determined by aggregate adult behavior, but, lacking accurate information, have to rely on the observed behavior of their adult parent to infer the norm. We show that this causes a signaling distortion in adult behavior. Compared to the benchmark case of no signaling, parents have a higher propensity to adopt attitudes that encourage their children to behave in a socially safe way, i.e. the way which would be optimal under maximum uncertainty about the prevailing social norm. This distortion is different in nature from the typical distortion due to a conflict of interest between sender and receiver in standard signaling games. The norm-signaling bias is self-reinforcing and might lead both to (Pareto) superior and inferior outcomes relative to the case of no signaling. We discuss applications to sexual attitudes, collective reputation, and trust.
North-American Lidcombe Program file audit: Replication and meta-analysis

Thousands of North American clinicians have trained for the Lidcombe Program of Early Stuttering Intervention, yet there are no benchmark data for that continent. This retrospective file audit includes logistical regression of variables from files of 134 children younger than 6 years who completed Stage 1 of the Lidcombe Program. Benchmarking data for clinic visits to Stage 2 is available for these files. Meta-analysis supplements worldwide Lidcombe Program benchmark data. The median number of clinic visits to Stage 2 was 11. High pre-treatment stuttering severity predicted more clinic visits than low severity. A trend toward statistical significance was found for the frequency of clinic visits. Frequent attendance of mean less than 11 days was associated with longer treatment times than infrequent attendance of mean 11 days or more. Results for North America were consistent with benchmark data from the UK and Australia. The mean attendance trend is clinically important and requires further investigation because of its potential clinical significance.
Logic induction of valid behavior specifications for intrusion detection

This paper introduces an automated technique for constructing valid behavior specifications of programs (at the system call level) that are independent of system vulnerabilities and are highly effective in identifying intrusions. The technique employs a machine learning method, inductive logic programming (ILP), for synthesizing first order logic formulas that describe the valid operations of a program from the normal runs of the program. ILP backed by theories and techniques extended from computational logic, allows the use of complex domain-specific background knowledge in the learning process to produce sound and consistent knowledge. A specification induction engine has been developed by extending an existing ILP tool and has been used to construct specifications for several (>10) privileged programs in Unix. Coupling with rich background knowledge in systems and security, the prototype induction engine generates human understandable and analytable specifications that are as good as those specified by a human. Preliminary experiments with existing attacks show that the generated specifications are highly effective in detecting attacks that subvert privileged programs to gain unauthorized accesses to resources.
Open Access Research Article Association between Occupation and Knee and Hip Replacement Due to Osteoarthritis: a Case-control Study

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction: The objective of this study was to examine the association between occupation and osteoarthritis (OA) leading to total knee (TKR) or hip (THR) joint replacement. Methods: The following is the case-control study design. All patients still living in Iceland who had had a TKR or THR due to OA as of the end of 2002 were invited to participate. First degree relatives of participating patients served as controls. N = 1,408 cases (832 women) and n = 1,082 controls (592 women), 60 years or older and who had adequately answered a questionnaire were analyzed. Occupations were classified according to international standards. Inheritance of occupations was calculated by using the Icelandic Genealogy Database. Results: The age adjusted odds ratio (OR) for male farmers getting a TKR due to OA was 5.1 (95% confidence interval (CI) 2.1 to 12.4) and for a male farmer getting a THR due to OA the OR was 3.6 (95% CI 2.1 to 6.2). The OR for a fisherman getting a TKR was 3.3 (95% CI 1.3 to 8.4). No other occupations showed increased risk for men. For women there was no increased risk for any occupation. Farming and fishing were also the occupations that showed the greatest degree of inheritance. Conclusions: These results support an association in males between occupations with heavy physical load and both TKR and THR for OA. Introduction There are several possible risk factors for osteoarthritis (OA) of the knee and hip. Body mass index (BMI) is well established as a risk factor for both hip and knee OA for both genders [1,2]. It has been shown that high BMI precedes knee OA and thus causality can be assumed [3,4]. Occupation is another risk factor that has been linked to OA. Studies have varied in their design, in both definition of OA and exposure to workload. Most of the higher quality studies have based their definition on radio-graphic OA [5-9] or the case population has been individuals that are waiting for [10,11] or have received [12-17] a joint prosthesis. From a clinical standpoint, studies based on radiographic OA are less relevant, as there is poor correlation between radiographic OA and symptoms [18,19]. Exposure has either been defined from job titles
Sperm competition and sex allocation in simultaneous hermaphrodites : A new look at Charnov's invariance principle

Recently, Charnov (1996) investigated the consequences of sperm competition for optimal sex allocation in simultaneous hermaphrodites. Charnov argued that the optimal sex allocation strategy can be derived on the basis of the 'sperm displacement rule'; that is, the function describing the relationship between sperm production and sperm displacement. Based on three specific examples of such sperm displacement rules, Charnov claimed that the details of the relationship between ejaculate volume and sperm displacement have only a minor effect on the optimal sex allocation strategy. We demonstrate that this 'invariance principle' is less general than suggested. The optimal sex allocation strategy as a function of the dimensionless quantity delta (ratio of maximum sperm volume to sperm storage volume) can have a wide variety of shapes. This is because Charnov's results depend crucially on two assumptions of questionable generality: diminishing displacement with investment in sperm and linear fitness returns with investment in eggs. We argue that deeper insights into optimal sex allocation are obtained if the allocation decision is partitioned into multiple components. Using this approach, we find a novel invariance principle: if egg survival only depends on the investment per egg (and not on clutch size), then the shape of this relationship has no effect whatsoever on optimal allocation to eggs versus sperm.
Efficient Active Listening Room Compensation for Wave Field Synthesis

Wave field synthesis is an auralization technique which allows to control the entire wave field within the entire listening area. However, reflections in the listening room interfere with the auralized wave field and may impair the spatial reproduction. Active listening room compensation aims at reducing these impairments by using the playback system. Due to the high number of playback channels used for wave field synthesis, the existing approaches to room compensation are not applicable. A novel approach to active room compensation overcomes these problems by a transformation from the space-time to the wave domain and application of wave-domain adaptive filtering.
Pengembangan Instrumen Evaluasi Pembelajaran Microteaching Berbasis Perspekti Keterampilan Dasar Mengajar

Selama ini, evaluasi pembelajaran mata kuliah pegajaran mikro ( microteaching ) hanya terbatas pada penialaian secara formalitas yang kurang memberikan informasi mendalam mengenai keterlaksan akan dan capain tujuan pembelajaran mata kuliah pegajaran mikro ( microteaching ). Sehingga perlu adanya inovasi dalam pembelajaran mengingat mata kuliah ini merupakan tahap awal untuk mengasah kompetensi calon guru sebelum diterjunkan pada PPL. Salah satu inovasi penting yang perlu dikembangkan dalam mata kuliah pengajaran mikro ( microteaching ) adalah pengembangan instrumen evaluasi berbasis keterampilan dasar mengajar. Penelitian ini bertujuan untuk menghasilkan instrumen penilaian pembelajaran mata kuliah pengajaran mikro ( microteaching ) berbasis keterampilan dasar mengajar. Penelitian ini merupakan penelitian pengembangan. Langkah pengembangan dilakukan sebanyak empat kali yaitu: pendahuluan, pengembangan, uji lapangan dan diseminasi. Langkah pendahuluan di maksud untuk mandapat data awal baik dari pustaka maupun lapangan, kemudian pengembangan dimana pada tahap ini akan mengembangkan desain instrumen yang selanjutnya akan dilakukan ujicoba dengan melalui tahapan preliminary field test sehingga produk ini berupa instrumen evaluasi program pembelajaran mata kuliah pengajaran mikro ( microteaching ). Hasil penelitian, melalui analisis data kebutuhan diperoleh bahwa 1) belum adanya penilaian untuk mata kuliah pengajaran mikro ( microteaching ) yang menekankan penilaian secara jelas terhadap keterampilan dasar mengajar (KDM) untuk calon praktikan PPL di FKIP UAD. 2) masukan para ahli, kisi-kisi perlu diperbaiki, lebih di integrasi pada proses pembelajaran (pembukaan, inti dan penutup) dan memasukan unsur pendekatan pada kurikulum 2013 yaitu saintifik approach. 3) data ujicoba butir (empirik) dianalisis menggunakan product moment, diperoleh ada beberapa item/ pernyataan lebih kecil dari koefisien korelasi tabel untuk tara signifikasi 5%, Namun setelah revisi, semua item pernyataan valid. 4) Sedangkan untuk hasil analisis reliabilitas dengan menggunakan Alfa Cronbach diperoleh nilai hitung koefisien reliabiltas 0,715 yang tergolong reliabilitas tinggi. 5) untuk kualitas penggunaan/ keefektifan instrumen diperoleh dari 10 penilai 6 penilai menyatakan baik dengan persentase 60%, dan 4 orang menyatakan kurang dengan persentase 50%.
High-Speed Stream-Centric Dense Stereo and View Synthesis on Graphics Hardware

This paper presents an efficient image-based rendering system capable of performing online stereo matching and view synthesis at high speed, completely on the graphics processing unit (GPU). Given two rectified stereo images, our algorithm first extracts the disparity map with a stream-centric dense depth estimation approach. For high-quality view synthesis, multi-label masks are then automatically generated to postprocess occlusions and ambiguously estimated regions adaptively. To allow even faster interactive view generation, an alternative forward warping method is also integrated. The experiments show that photorealistic intermediate views of high image quality are yielded by our algorithm. The optimized implementation also provides the state-of-the-art stereo analysis and view synthesis speed, achieving over 47 fps with 450x375 stereo images and 60 disparity levels on an Nvidia GeForce 7900 graphics card.
Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization

In this study, new nano-fluor-hydroxyapatite (nFHA)/polyurethane composite scaffolds were fabricated for potential use in bone tissue engineering. Polyester urethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and 1,4-butanediol as chain extender. Nano fluor-hydroxyapatite (nFHA) was successfully synthesized by sol-gel method. The solid–liquid phase separation and solvent sublimation methods were used for preparation of the porous composites. Mechanical properties, chemical structure, and morphological characteristics of the samples were investigated by compressive test, Fourier transform infrared, and scanning electron microscopy (SEM) techniques, respectively. The effect of nFHA powder content on porosity and pore morphology was investigated. SEM images demonstrated that the scaffolds were constituted of interconnected and homogeneously distributed pores. The pore size of the scaffolds was in the range 50–250 μm. The result obtained in this research revealed that the porosity and pore average size decreased and compressive modulus increased with nFHA percentage. Considering morphological, physical, and mechanical properties, the scaffold with a higher ratio of nFHA has suitable potential use in tissue regeneration.
The relevance of embodiment to lexical and collocational meaning

This cognitive linguistic corpus-based study embraces Johnson’s (1992: 348) embodiment hypothesis to argue that metonymic and metaphorical extensions of the prototypical sense of Modern Greek prosopo are based on a cultural model of the self. It is also claimed that conceptual structure and cultural models interact equally in motivating different uses of prosopo , confirming the intimate connection between cultural experience and embodied behavior (Gibbs 1999: 146). Frequently occurring collocations of adjective + prosopo are shown to have developed meanings not directly relatable to either the semantics of prosopo or the semantics of the collocating adjectives, supporting Sinclair’s (1991) views on collocational meanings. It is suggested that the embodiment hypothesis is relevant not only to lexicalization and the expression of emotion, character, etc., but also to the emergence of abstract collocational meaning. Finally, the present work suggests the possibility of a methodological convergence of cognitive semantics, cultural models, lexical semantics, and corpus linguistics.
Connectivity of sensor networks with power control

In this paper, we consider a sensor network with an average of n nodes randomly placed over a region of unit area. We assume that each node is equipped with a wireless transceiver, and are interested in the minimum transmit power required for maintaining connectivity of the network when power control is employed (i.e., each node can choose a power level for transmission independent of any other node). We show that the average power gain per node (the ratio of the transmit power required without and with power control) increases with the (average) number of nodes n as (logn)/sup /spl alpha//2/, where /spl alpha/ is the path loss exponent.
MONETIZING SEARCH MARKETING : ONLINE RETAIL KEYWORD CHARACTERISTICS AND DECISIONS

To make judicious resource allocation decisions in search marketing, it is essential to understand the motives behind online shoppers’ searching and purchasing behavior. Taking the approach of understanding consumers’ desires to reduce cognitive load in online shopping, we construct a goal-related keyword characterization framework. Most search keywords reflect a combination of the following characteristics retailer specific, brand specific, product specific, feature related, and shopping intention. We analyze search ad visibility (including result rankings and dual-appearances), clickthrough, and revenue data associated with visitor-disclosed search keywords from a leading Web-only retailer over one year. We also investigate whether the relationships vary for head and tail keywords. Our findings show a variety of interesting impacts of keyword characteristics and dual-appearances of ads on search marketing performance. In addition, the impacts of search ad visibility on clickthrough are enhanced when searchers use head keywords. The contributions of the research include a comprehensive search keyword characterization framework, and the analysis of the relationships among keyword characteristics, search ad visibility, and search performance that have strong implications for search marketing monetization decisions.
Attentional Theory Is a Viable Explanation of the Inverse Base Rate Effect: A Reply to Winman, Wennerholm, and Juslin (2003)

A. Winman, P. Wennerholm, and P. Juslin (2003) have admitted that J. K. Kruschke (2001a) cogently demonstrated the shortcomings of eliminative inference as an explanation of the inverse base rate effect, but they raise criticisms of Kruschke’s attentionally based explanation. First, Winman et al. pointed out that attentional shifting does not improve learning performance in Kruschke’s (1996) ADIT model, contrary to the claims that attentional shifting accelerates learning. This reply demonstrates that the deceleration of learning is a natural consequence when attentional shifts are not learned, as is the case in ADIT; however, when attentional shifts are learned, as was assumed by the underlying theory and as is the case in the EXIT model (Kruschke, 2001a, 2001b), then performance is indeed accelerated by attentional shifts. Second, Winman et al. pointed out that, whereas EXIT captures essentially all of the notable effects in the transfer data, it fails to capture a small effect [viz., p(C PC) p(R PR)]. This reply demonstrates that when this trend in the data is merely weighted more heavily in the model fitting, then the EXIT model accommodates it. EXIT accomplishes this by emphasizing base rate learning more strongly. Thus, the EXIT model, and attentional theory more generally, remains a viable explanation of the inverse base rate effect.
Emotional Intelligence, Emotional Labor, and Emotional Exhaustion among Korean Fitness Employees

ABSTRACT The purpose of this study was to examine the relationships among emotional intelligence, two forms of emotional labor (i.e. surface acting and deep acting), and emotional exhaustion among Korean fitness employees. A total of 217 participants completed the questionnaires measuring their level of emotional intelligence, surface acting, deep acting, and emotional exhaustion. The results indicated that emotional intelligence had a positive impact on surface acting and a negative impact on deep acting. Furthermore, a negative link between surface acting and emotional exhaustion was found, whereas no significant link was displayed between deep acting and emotional exhaustion. The results also revealed that different types of emotional labor fitness employees utilize can impact various employee well-being outcomes. In addition, emotional intelligence was found to play an important role in selecting health-detrimental strategy of surface acting among fitness employees.