Miracle-dz/UniFAR-FTUs huggingface dataset:
Change in Long-Spacing Collagen in Descemet's Membrane of Diabetic Goto-Kakizaki Rats and Its Suppression by Antidiabetic Agents

We examined changes in the ultrastructure and localization of major extracellular matrix components, including 5 types of collagen (type I, III, IV, VI, and VIII), laminin, fibronectin, and heparan sulfate proteoglycan in Descemet's membrane of the cornea of diabetic GK rats. In the cornea of diabetic GK rats, more long-spacing collagen fibrils were observed in Descemet's membrane than in the membrane of the nondiabetic Wistar rats. Both GK and Wistar rats showed an age-dependent increase in the density of the long-spacing collagen. Immunoelectron microscopy showed that type VIII collagen was localized in the internodal region of the long-spacing collagen, which was not labelled by any of the other antibodies used. The antidiabetic agents nateglinide and glibenclamide significantly suppressed the formation of the long-spacing collagen in the diabetic rats. Long-spacing collagen would thus be a useful indicator for studying diabetic changes in the cornea and the effect of antidiabetic agents.
Running Backs in the NFL Draft and NFL Combine : Can Performance be Predicted ?

i Acknowledgements I would like to thank everyone who has contributed to the completion of this thesis in any way, shape, or form. First, I would like to thank my entire family, especially my father Jonathan, for helping me with my writing for so many years. I would like to thank my mother Carri, for providing constant support and reassurance through this entire process. I would also like to thank Tejas Gala for his tremendous help and friendship not just with this paper, but with all aspects of CMC. Finally, I would like to thank my reader Professor Heather Antecol. Without her support and her willingness to help me with the project, this thesis would not have been possible. Abstract Berri and Simmons (2009) investigate the relationship between the NFL Combine and the NFL Draft. They find that a quarterback's performance in the Combine can have a significant impact on that player's draft position. However, they find that no known aspect of a quarterback before they are drafted is an indicator of success in the NFL. I examine if these relationships exist for the Running Back position. I find similar results to Berri and Simmons: that performance in the Combine does have an effect on that player's draft position, but that no aspect of a running back's pre-draft characteristics can be seen as a sign of future NFL success.
Long-term outcome of autologous stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma.

BACKGROUND The purpose of this study was to assess prognostic factors and outcome of patients with relapsed/refractory Hodgkin's lymphoma (HL) who received high-dose chemotherapy and autologous stem-cell transplant (ASCT). PATIENTS AND METHODS Data on 195 patients who received ASCT between 1985 and June 2005 were reviewed. Median time from first treatment to ASCT was 2.6 years (0.4-27.3). Demography at ASCT was 61% stage IV, median age 31 years (18-69), median prior treatment (tx) regimens 3 (2-7), median Hasenclever index 3 (0-6); 150 patients had responding disease [54 complete remission (CR), 96 partial remission (PR)], and 45 patients had untested relapse/refractory disease. RESULTS Post-ASCT, 61% (119/195) patients attained CR with an overall response (CR + PR) of 85%. Twelve patients had nonrelapse mortality. Of 119 patients attaining CR, 27 relapsed: 3 after attaining CR for >5 years and 1 after attaining CR for >10 years. Median overall survival (OS)/progression-free survival (PFS) from ASCT was 9 years/2.9 years. Five-year OS/PFS was 55% of 44% and 10-year OS/PFS was 49.4% of 37% for whole group. Twenty (10%) patients developed second cancer (seven secondary acute myeloid leukaemia (AML)/myelodysplastic syndrome (MDS)). Probability of developing second cancer at 10 years was 14.7% (95% confidence interval 8.9% to 23.8%) and 24.8% at 19 years. CONCLUSION These data provide the longest follow-up reported for patients receiving ASCT for relapsed/refractory HL. In addition to previously described prognostic factors, our data show that Hasenclever index <3 influences outcome favorably and attaining CR at ASCT leads to a better outcome.
Bioinformatics analysis of the structural and evolutionary characteristics for toll-like receptor 15

Toll-like receptors (TLRs) play important role in the innate immune system. TLR15 is reported to have a unique role in defense against pathogens, but its structural and evolution characterizations are still poorly understood. In this study, we identified 57 completed TLR15 genes from avian and reptilian genomes. TLR15 clustered into an individual clade and was closely related to family 1 on the phylogenetic tree. Unlike the TLRs in family 1 with the broken asparagine ladders in the middle, TLR15 ectodomain had an intact asparagine ladder that is critical to maintain the overall shape of ectodomain. The conservation analysis found that TLR15 ectodomain had a highly evolutionarily conserved region on the convex surface of LRR11 module, which is probably involved in TLR15 activation process. Furthermore, the protein–protein docking analysis indicated that TLR15 TIR domains have the potential to form homodimers, the predicted interaction interface of TIR dimer was formed mainly by residues from the BB-loops and αC-helixes. Although TLR15 mainly underwent purifying selection, we detected 27 sites under positive selection for TLR15, 24 of which are located on its ectodomain. Our observations suggest the structural features of TLR15 which may be relevant to its function, but which requires further experimental validation.
RNA interference targeting Aurora-A sensitizes glioblastoma cells to temozolomide chemotherapy

Clinically, temozolomide (TMZ) is widely used in glioblastoma (GBM) treatment. However, the toxicity of TMZ may influence the quality of patient life. Thus, novel treatment options for sensitizing GBM cells to TMZ chemotherapy are necessary. Aurora-A is widely expressed in GBM and correlated with poor prognosis. It has been proven to be an effective target for gene therapy and chemotherapy. In the present study, short hairpin (sh)RNA targeting Aurora-A was employed to knockdown Aurora-A expression in GBM cells. Cell Counting Kit-8 assays, flow cytometry, colony formation assays, invasion assays and tube formation assays were used to determine the effects of Aurora-A knockdown when combined with TMZ treatment. A U251 subcutaneous cancer model was established to evaluate the efficacy of combined therapy. The results of the present study indicated that the proliferation, colony formation, invasion and angiogenesis of GBM cells were significantly inhibited by combined therapy when compared with TMZ treatment alone. In vivo results demonstrated that knockdown of Aurora-A significantly (P=0.0084) sensitizes GBM cells to TMZ chemotherapy. The results of the present study demonstrated that knockdown of Aurora-A in GBM cells enhances TMZ sensitivity in vitro and in vivo. Therefore, Aurora-A knockdown may be a novel treatment option for decreasing TMZ toxicity and improving patient quality of life.
Constraint-based stoichiometric modelling from single organisms to microbial communities

Microbial communities are ubiquitously found in Nature and have direct implications for the environment, human health and biotechnology. The species composition and overall function of microbial communities are largely shaped by metabolic interactions such as competition for resources and cross-feeding. Although considerable scientific progress has been made towards mapping and modelling species-level metabolism, elucidating the metabolic exchanges between microorganisms and steering the community dynamics remain an enormous scientific challenge. In view of the complexity, computational models of microbial communities are essential to obtain systems-level understanding of ecosystem functioning. This review discusses the applications and limitations of constraint-based stoichiometric modelling tools, and in particular flux balance analysis (FBA). We explain this approach from first principles and identify the challenges one faces when extending it to communities, and discuss the approaches used in the field in view of these challenges. We distinguish between steady-state and dynamic FBA approaches extended to communities. We conclude that much progress has been made, but many of the challenges are still open.
Do health investments improve agricultural productivity: Lessons from agricultural household and health research

The link between good health and economic prosperity is well established and can be detected in numerous measures, such as increased income, wages, efficiency, and productivity. While the link can readily be seen in descriptive statistics, however, it is another matter to disentangle the precise nature of the connection. It is likely that causality runs in both directions, and both health and prosperity clearly are affected by numerous other variables.
Economic Forecast Evaluation: Profits versus the Conventional Error Measures

Economists are often puzzled as to why profit-maximizing firms buy professional forecasts when statistics such as the root-mean-squared error or the mean absolute error often indicate that a naive model will forecast about as well. This paper argues that the reason is that these traditional summary statistics may not be closely related to a forecast's profits. Using profit measures, the authors find only very weak relationships between such summary error statistics and forecast value. If these results are robust, then least-squares regression analysis may not be appropriate for many studies of economic behavior. Copyright 1991 by American Economic Association.
Heterogeneous bids in auctions with rational and markdown bidders—Theory and Experiment

We present results from a series of experiments that allow us to measure overbidding and, in particular, underbidding in first-price auctions. We investigate how the amount of underbidding depends on seemingly innocent parameters of the experimental setup. To structure our data we present and test a theory of constant markdown bids. While a fraction of bidders can be well described by Bayesian Nash equilibrium bids, a larger fraction seems to either use constant markdown bids or seems to rationally optimise against a population where some members use markdown bids and some are rational.
Optimal contracts for central bankers

This paper adopts a principal-agent framework to determine how a central banker's incentives should be structured to induce the socially optimal policy. In contrast to previous findings using ad hoc targeting rules, the inflation bias of discretionary policy is eliminated and an optimal response to shocks is achieved by the optimal incentive contract, even in the presence of private central-bank information. In the one-period model that has formed the basis for much of the literature on discretionary monetary policy, it is shown that the optimal contract ties the rewards of the central banker to realized inflation. Copyright 1995 by American Economic Association.
Dynamic Higher Order Expectations

In models where privately informed agents interact, they may need to form higher-order expectations, i.e. expectations about other agents' expectations. In this paper we prove that there exists a unique equilibrium in a class of linear dynamic rational expectations models in which privately informed agents form higher order expectations. We propose an iterative procedure that recursively computes increasing orders of expectations. The algorithm is a contraction mapping, and the implied dynamics of the endogenous variables converge to the unique equilibrium of the model. The contractive property of the algorithm implies that, in spite of the fact that the model features an infinite regress of expectations, the equilibrium dynamics of the model can be approximated to an arbitrary accuracy with a finite-dimensional state. We provide explicit bounds on the approximation errors. These results hold under quite general conditions: It is sufficient that agents discount the future and that the exogenous processes follow stationary (but otherwise unrestricted) VARMA processes.
THE LYMAN ALPHA MORPHOLOGY OF LOCAL STARBURST GALAXIES: RELEASE OF CALIBRATED IMAGES

We present reduced and calibrated high resolution Lyman-alpha (Lyα) images for a sample of six local star-forming galaxies. Targets were selected to represent a range in luminosity and metallicity and to include both known Lyα emitters and nonemitters. Far ultraviolet imaging was carried out with the Solar Blind Channel of the Advanced Camera for Surveys on the Hubble Space Telescope (HST) in the F122M (Lyα online) and F140LP (continuum) filters. The resulting Lyα images are the product of careful modeling of both the stellar and nebular continua, facilitated by supporting HST imaging at λ ≈ 2200, 3300, 4400, 5500, Hα, and 8000 Å, combined with Starburst 99 evolutionary synthesis models, and prescriptions for dust extinction on the continuum. In all, the resulting morphologies in Lyα, Hα, and UV continuum are qualitatively very different and we show that the bulk of Lyα emerges in a diffuse component resulting from resonant scattering events. Lyα escape fractions, computed from integrated Hα luminosities and recombination theory, are found never to exceed 14%. Internal dust extinction is estimated in each pixel and used to correct Lyα fluxes. However, the extinction corrections are far too small (by factors from 2.6 to infinity) to reconcile the emerging global Lyα luminosities with standard recombination predictions. Surprisingly, when comparing the global equivalent widths of Lyα and Hα, the two quantities appear to be anticorrelated, which may be due to the evolution of mechanical feedback from the starburst. This calls for caution in the interpretation of Lyα observations in terms of star formation rates. The images presented have a physical resolution 3 orders of magnitude better than attainable at high redshifts from the ground with current instrumentation and our images may therefore serve as useful templates for comparing with observations and modeling of primeval galaxy formation. We therefore provide the reduced Lyα, Hα, and continuum images to the community.
Performance Analysis of Split Preamble RAN Over-load Protocol for M2M Communications in Cellular Networks

Machine type communications (MTC) in 3G/4G networks is getting more attention recently due to bursty nature of traffic characteristics in contrast to Poisson type H2H traffic. A large number of methods have been suggested in the literature. In this paper we give a mathematical model on performance analysis of Disjoint Allocation (DA) and Joint Allocation (JA) methods for allocating preambles to M2M and H2H users. In an earlier work we had investigated the performance of two possible splitting preamble methods on collision probability and energy reduction for MTC subscribers. In this paper we develop a stochastic model for JA/DA method in RACH procedure using a $K$th order Markov chain approach and carry out performance analysis in terms of collision probability, access success probability, average access delay, statistics of preamble transmissions and statistics of access delay for M2M users. The optimal number of reserved preamble set is derived based on the given success access delay threshold. Numerical results verifies the simulation results and demonstrates that this model can estimate the performance of the JA/DA method accurately.
Enhancement of Application Software for Examination of Differential Magnification Methods and Magnification Interface Factors

The variable visual acuity nature of human vision across fovea and periphery prompted the need to study the differential magnification method as compared with the traditional linear magnification. With differential magnification, outer-area objects were magnified at a level higher than the inner-area objects. An application software was specially developed by the authors previously for the examination of differential linear and traditional linear magnification methods. This paper presents the enhancement of the application software and the addition of other magnification interface factors which worth further investigating. The newly designed differential nonlinear magnification method was featured and comparisons were made with the differential linear and the traditionally linear magnification methods.
Questions on relatively hyperbolic groups and related classes

The notion of a group hyperbolic relative to a collection of subgroups was originally proposed by Gromov [15]. Since then many definitions of relatively hyperbolic groups were suggested by Bowditch [5], Farb [13], Drutu-Osin-Sapir [11, 33], Groves-Manning [17], Osin [29], Yaman [38] and others. All these definitions except for those suggested in [29] are equivalent and require the group to be finitely generated and the collection of subgroup to be finite (while some of them can be easily extended to the general case). The definition from [29] is more general but is equivalent to others when restricted to finitely generated groups. For instance, a free product A∗B is always hyperbolic relative to {A,B} in the sense of [29], but is relatively hyperbolic in the sense of the other definitions iff both A and B are finitely generated. Throughout this list of problems we allow relatively hyperbolic groups to be infinitely generated, unless the converse is explicitly stated. If a group G is hyperbolic relative to a finite collection of finitely presented subgroups {Hλ}λ∈Λ, then G is finitely presented (easy exercise). In the other direction, the only known fact is that if a finitely generated group G is hyperbolic relative to a collection of subgroups {Hλ}λ∈Λ, then the collection is finite and each of the subgroups is finitely generated [29].
Education and earnings

According to the Bureau of Labor Statistics (BLS), achieving a higher level of education is one way to guard against unemployment and increase earnings: A 2008 report found that workers with a bachelor’s degree earned 65 percent more than workers with only a high school diploma and nearly 130 percent more than workers without a high school diploma.
Remembering Early Childhood

In this article, we consider recent research on three questions about people's memories for their early childhood: whether childhood amnesia is a real phenomenon, whether implicit memories survive when explicit memories do not, and why early episodic memories are sketchy. The research leads us to form three conclusions. First, we argue that childhood amnesia is a real phenomenon, as long as the term is defined clearly. Specifically, people are able to recall parts of their lives from the period between ages 2 and 5 years, but they recall less from that period than from other periods. Second, we conclude that implicit memories from early childhood may be evident even when explicit memories are not, a finding that suggests early experience may affect behavior in ways that people do not consciously recognize. Third, we argue that although young children are well known to be wonderfully efficient learners of semantic information, they have difficulty in either encoding or retrieving the interlinked aspects of events that lend them their autobiographical character. Although more evidence is needed, the relative lack of episodic memories of early childhood may be linked to maturation of prefrontal cortex.
Expression Microarray and Mouse Virulence Analysis of Four Conserved Two-Component Gene Regulatory Systems in Group A Streptococcus

ABSTRACT Group A streptococcus (GAS) is a gram-positive human bacterial pathogen that causes diseases ranging from relatively mild epithelial cell surface infections to life-threatening invasive episodes. Much is known about the extracellular molecules that contribute to host-pathogen interactions, but in contrast, far less information is available about regulatory genes that control the expression of individual or multiple GAS virulence factors. The eight GAS genomes that have been sequenced have 12 conserved two-component gene regulatory systems (TCSs), but only 3 of these 12 have been studied in detail. Using an allelic replacement strategy with a nonpolar cassette, we inactivated the response regulator of four TCSs that have only weak homology with TCS genes of known or inferred function in other bacteria. The mutant strains were analyzed by expression microarray analysis at four time points and tested in two mouse infection models. Each TCS influenced expression (directly or indirectly) of 12 to 41% of all chromosomal genes, as assessed by growth in Todd-Hewitt broth and a custom Affymetrix GeneChip. None of the isogenic mutant strains was significantly altered for mouse virulence based on intraperitoneal inoculation. Similarly, compared to the wild-type strain, there was no significant difference in skin lesion size for three of the four mutants. In contrast, the ΔM5005_Spy_0680 mutant strain produced significantly larger abscesses after subcutaneous inoculation into mice, consistent with a hypervirulence phenotype. The mutant strain had significantly higher in vitro expression of several proven and putative virulence genes, including scpA, encoding a peptidase that inactivates complement protein C5a. Together, the data provide new information about previously uncharacterized GAS TCSs.
Nuclear Factor Kappa B, Matrix Metalloproteinase-1, p53, and Ki-67 Expressions in the Primary Tumors and the Lymph Node Metastases of Colorectal Cancer Cases

Colorectal cancer (CRC) is the third most frequent malignancy. Many factors such as NF-κB, matrix metalloproteinase-1 (MMP-1), p53, and Ki-67 are likely to be involved in its development and progression. Lymph node metastases indicate increased tumor burden and tumor cell heterogeneity and affect both the treatment strategies and the prognosis. In this study, expressions of NF-κB, MMP-1, p53, and Ki-67 were between the primary tumors and lymph node metastases in 110 Dukes' stage C, CRC cases by immunohistochemical methods, related to patients' clinical outcomes. NF-κB, p53, and Ki-67 expressions were significantly higher in the metastatic lymph nodes compared to the primary tumor tissues (P = 0.04, P = 0.04, and P = 0.01, resp.). In the metastatic lymph nodes NF-κB expression was correlated with both p53 (r = 0.546, P = 0.003) and Ki-67 (r = 0.586, P = 0.0001) expressions. The univariant and multivariant analyses showed that only “pT stage” preserved an independent prognostic significance for recurrence-free survival rates and 5-year overall survival rates (P < 0.001 for both). Metastatic cells can acquire different biological characteristics compared to their primaries. Elucidation of properties acquired by metastatic cells is important in order to better determine prognosis, reverse drug resistance, and discover new treatment alternatives.
Never Leave Well Enough Alone

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