Miracle-dz/UniFAR-FTUs huggingface dataset:
Design of a Novel Low Cost Point of Care Tampon (POCkeT) Colposcope for Use in Resource Limited Settings

Introduction Current guidelines by WHO for cervical cancer screening in low- and middle-income countries involves visual inspection with acetic acid (VIA) of the cervix, followed by treatment during the same visit or a subsequent visit with cryotherapy if a suspicious lesion is found. Implementation of these guidelines is hampered by a lack of: trained health workers, reliable technology, and access to screening facilities. A low cost ultra-portable Point of Care Tampon based digital colposcope (POCkeT Colposcope) for use at the community level setting, which has the unique form factor of a tampon, can be inserted into the vagina to capture images of the cervix, which are on par with that of a state of the art colposcope, at a fraction of the cost. A repository of images to be compiled that can be used to empower front line workers to become more effective through virtual dynamic training. By task shifting to the community setting, this technology could potentially provide significantly greater cervical screening access to where the most vulnerable women live. The POCkeT Colposcope’s concentric LED ring provides comparable white and green field illumination at a fraction of the electrical power required in commercial colposcopes. Evaluation with standard optical imaging targets to assess the POCkeT Colposcope against the state of the art digital colposcope and other VIAM technologies. Results Our POCkeT Colposcope has comparable resolving power, color reproduction accuracy, minimal lens distortion, and illumination when compared to commercially available colposcopes. In vitro and pilot in vivo imaging results are promising with our POCkeT Colposcope capturing comparable quality images to commercial systems. Conclusion The POCkeT Colposcope is capable of capturing images suitable for cervical lesion analysis. Our portable low cost system could potentially increase access to cervical cancer screening in limited resource settings through task shifting to community health workers.
Development and initial validation of the Brief Adolescent Life Event Scale (BALES)

We report initial validity analyses of the Brief Adolescent Life Event Scale (BALES). This instrument addresses negative and positive events pertinent to the well being of adolescent boys and girls, and is designed for use in studies utilizing an extended research protocol. Selection of items was guided by emerging perspectives on positive psychology , action theory , and personality vulnerability , as well as by new developments in statistical modeling theory. The 36 items of the scale tap negative and positive events, each of which addresses interpersonal and achievement life domains. Using a large sample of early-adolescents ( N = 895), we confirmed the hypothesized structure that includes four domain-level latent factors (i.e., negative interpersonal events, negative achievement events, positive interpersonal events, positive achievement events), and two overarching factors (negative events and positive events). Indices of positive and negative events predicted adolescent depressive symptoms in expected ways, and positive events buffered the effect of negative events on depressive symptoms. These findings encourage an informed use of the BALES and highlight considerations involved in the development of brief measures of stress and coping processes.
Experiences of Latino Families With Their Child's Special Education Program

The goal of the study was to develop a better understanding of how Latino families with children with disabilities perceive their child's special education program and their involvement in school. Participants were families of children with disabilities attending a predominately Latino elementary school in a large, urban school district. Forty-four families participated in a questionnaire and a representative subgroup (n = 16) were interviewed individually. Findings revealed that overall families were quite satisfied with their child's special education program and with their own involvement. The majority of families indicated that they received regular communication and were satisfied with the overall school to home communication. However, some families still wanted more information about classroom activities and expressed frustration with communication citing their limited English skills as the primary source of difficulty.
A controlled trial comparing continued zidovudine with didanosine in human immunodeficiency virus infection. The NIAID AIDS Clinical Trials Group.

BACKGROUND Although zidovudine is effective in patients with human immunodeficiency virus (HIV) infection, its efficacy may decline with prolonged use. Didanosine is another inhibitor of HIV reverse transcriptase. We evaluated the effectiveness of changing anti-HIV treatment from zidovudine to didanosine. METHODS This multicenter, double-blind study involved 913 patients who had tolerated zidovudine for at least 16 weeks. The patients had the acquired immunodeficiency syndrome (AIDS), AIDS-related complex with less than or equal to 300 CD4 cells per cubic milliliter, or asymptomatic HIV infection with less than or equal to 200 CD4 cells per cubic milliliter. They were randomly assigned to receive 600 mg per day of zidovudine, 750 mg per day of didanosine, or 500 mg per day of didanosine. RESULTS There were significantly fewer new AIDS-defining events and deaths among the 298 subjects assigned to 500 mg per day of didanosine than among the subjects who continued to receive zidovudine (relative risk, 1.39; 95 percent confidence interval, 1.06 to 1.82; P = 0.015). With 750 mg of didanosine, there was no clear benefit over zidovudine (relative risk, 1.10; 95 percent confidence interval, 0.86 to 1.42). The efficacy of didanosine was unrelated to the duration of previous zidovudine treatment. In the two didanosine groups, there were improvements in the number of CD4 cells (P less than 0.001 for both groups) and in p24 antigen levels (P = 0.03 in the 500-mg group; P = 0.005 in the 750-mg group), as compared with the zidovudine group. CONCLUSIONS Changing treatment from zidovudine to 500 mg per day of didanosine appears to slow the progression of HIV disease.
A phoneme-space-representation heuristic to improve the performance in a cryptographic-speech-key generation task

In this paper we propose an improvement in the generation of the cryptographic-speech-key by using an heuristic consisting on the selection of the dimensions with the best performance for each of the phonemes. This selection can be made thanks that we know the phonemes of the spoken user passphrase. First, the mel frequency cepstral coeﬃcients, (ﬁrst and second derivatives) of the speech signal are calculated. Then, an Automatic Speech Recogniser, which models are previously trained, is used to detect the phoneme limits in the speech utter-ance. Afterwards, the feature vectors are built using both the phoneme-speech models and the information obtained from the phoneme segmentation. Next, the Support Vector Machines classiﬁer, relying on an RBF kernel, computes the cryptographic key. By applying the phoneme-space-representation heuristic our results show an improvement of 24.26%, 18.85%, 16.56% for 10, 20 and 30 speakers, from the YOHO database, respectively, compared with our previous results.
Bacteremic Urinary Tract Infection Caused by Multidrug-Resistant Enterobacteriaceae Are Associated With Severe Sepsis at Admission

Abstract The purpose of this study is to compare the clinical features and treatment outcomes among patients with bacteremic urinary tract infection (UTI) caused by multidrug-resistant (MDR) and non-MDR Enterobacteriaceae and to identify whether MDR pathogens were independently associated with severe sepsis or septic shock at presentation. The clinical data of adult patients visiting and being treated at Chia-Yi Christian Hospital due to bacteremic UTI caused by Enterobacteriaceae from January 2006 to August 2015 were retrospectively analyzed. A total of 585 patients were enrolled. Among them, 220 (37.6%) were caused by the MDR Enterobacteriaceae. A total of 206 patients (35.2%) developed severe sepsis or septic shock at presentation. Patients in the MDR group tend to be male and have a past history of gout, recurrent UTI, prior hospitalization, hydronephrosis, renal stone, ureteral stone, indwelling urinary catheter, newly development of renal dysfunction, severe sepsis or septic shock, intensive care unit (ICU) admission, receipt of ineffective empirical therapy, longer hospital stay, and higher in-hospital mortality (2.7% vs 1.9%, P = 0.569). Using multivariate logistic regression analysis, it is revealed that independent predictors associated with severe sepsis or septic shock at presentation were liver cirrhosis (OR 2.868; 95% CI 1.439–5.716; P = 0.003), indwelling urinary catheter (OR 1.936; 95% CI 1.238–3.027; P = 0.004), and MDR Enterobacteriaceae (OR 1.447; 95% CI 1.002–2.090; P = 0.049). Multidrug resistance was associated with the development of severe sepsis or septic shock upon presentation among patients with bacteremic UTI caused by Enterobacteriaceae. Therefore, empirical antibiotics therapy for patients with UTI presented with severe sepsis and/or septic shock should be more broad-spectrum to effectively cover MDR Enterobacteriaceae.
Pilot evaluation of web enabled symptom monitoring in cystic fibrosis

Background: People with cystic fibrosis (CF) frequently experience isolation and are subjected to extensive complex treatment regimens which could be complemented by remote support. In the current research this is particularly relevant as the location, Tasmania, has the second highest incidence of CF in the world. This paper provides an overview of the evaluation of a pilot trial of an information system conceptualised and developed to assist people with CF, and their families, to enhance their skills and communication in relation to self-management for their condition. Methods: The pilot involved people with CF ranging in age from 19 months to 52 years and their families. The primary outcome was the perceived usability of the online-symptom diary from the user’s perspective. To assess perceived usability qualitative semi-structured interviews were conducted pre- and post-pilot and analysed using thematic coding. Results: Participants initially and primarily perceived myCF as a system that would help others and enable peer support. Connectivity and involvement were highlighted as complex issues that needed consideration. Conclusion: There was an overall encouraging response to the pilot and indications that the use of information communication technology to complement health care delivery and facilitate self-care skills may be particularly suited to the Australian context where geographical distances and isolation provide a relative barrier to specialist care for chronic complex conditions.
Reconstitution of a porin-deficient mutant of Haemophilus influenzae type b with a porin gene from nontypeable H. influenzae

The major outer membrane protein (OmpP2) of nontypeable Haemophilus influenzae (NTHI) has been shown to vary markedly with respect to both size and the presence of specific surface-exposed epitopes among strains of this unencapsulated pathogen. In contrast, the OmpP2 proteins of H. influenzae type b (Hib) strains are well conserved at the level of primary protein structure and have in common several surface-exposed antigenic determinants that have not been detected in NTHI strains. The availability of an isogenic, avirulent Hib ompP2 mutant made it possible to investigate whether an NTHI OmpP2 protein could function properly in the Hib outer membrane. A plasmid shuttle vector (pGJB103) was used to clone the ompP2 gene from NTHI TN106 into a recombination-deficient H. influenzae strain in which expression of the NTHI OmpP2 protein was detected by means of an NTHI TN106 OmpP2-specific monoclonal antibody. The amino acid sequence of this NTHI OmpP2 protein, as deduced from the nucleotide sequence of the NTHI TN106 ompP2 gene, was determined to be 83% identical to that of the Hib OmpP2 protein. Transformation of this cloned NTHI ompP2 gene into the Hib ompP2 mutant yielded a Hib transformant strain that expressed the NTHI OmpP2 protein. Expression of this NTHI OmpP2 protein allowed the Hib ompP2 mutant, which normally grows poorly in vitro, to grow in a manner indistinguishable from that of the wild-type Hib strain. More importantly, the introduction of this functional NTHI ompP2 gene into the avirulent Hib ompP2 mutant restored the virulence of this strain to wild-type levels. These results indicate that an NTHI OmpP2 protein can be expressed and function properly in the Hib outer membrane.
Researching the Trainability of Transformational Organizational Leadership

Findings about the effectiveness of leadership training vary. This research tests for the effectiveness of transformational leadership training, using the Full Range Leadership Development (FRLD) programme, upon leader behaviours and interactions. The impact of transformational leadership upon organizational performance has already been established. Quasi-field experiment research was conducted, resulting in an increase in the display of all five transformational leadership factors and contingent reward behaviour. There was a reduction in the display of passive transactional leadership behaviour as a result of the training. The extra effort of followers was increased. Goal-setting was found to be effective. Implications are discussed for practitioners and for future research.
Sit Big to Eat Big

Body image concern has long been linked with unhealthy restrained eating patterns among women, yet scant research has examined factors to disrupt this process. At the same time, feminine stereotypes prescribe that women should be small, restrict their movements, speak softly, and limit their food intake (e.g., through dieting). Here, we examined whether women’s postural constriction or expansion moderated the relation between body shape concern and restrained eating, predicting that expansive postures would interrupt this robust relation. As a secondary aim, we investigated whether women spontaneously adopted constrictive postures and to what extent postures contributed to restrained eating under baseline conditions. Specifically, women’s postural position (constricted, expanded, or baseline posture) was manipulated and restrained eating was measured. Results showed that at high levels of body shape concern, women sitting in expansive postures restrained their eating less compared to women in constrictive postures. Further, spontaneously expansive (vs. spontaneously constrictive) postures were associated with less restrained eating among women. Thus, postural expansion attenuated the link between body shape concern and restrained eating whereas postural constriction exacerbated the link. Implications for gender performativity and possible interventions for restrained eating are discussed.
Comanagement of patients with congestive heart failure by family physicians and cardiologists: frequency, timing, and patient characteristics.

BACKGROUND Many patients with congestive heart failure (CHF) receive care solely from a primary care physician, while some receive care from both a primary care physician and a cardiologist. Patients in the latter type of care relationships have not been described. The principal objectives of our study were to determine what percentage of patients with CHF are comanaged, the characteristics of comanaged CHF patients, and when in the natural history of CHF this relationship is initiated. METHODS A retrospective record review was conducted of all patients who met the modified Framingham criteria for the diagnosis of CHF in a large community-based family practice office. Comanagement was defined as an ongoing relationship with a cardiologist characterized by a minimum of one visit to the cardiologist's office in the year of evaluation. We divided the natural history of CHF into 4 stages to describe the timing of the initial referral to the cardiologist: I Prediagnosis; II Diagnosis; III Progression; and IV Terminal. RESULTS Of 151 patients identified with CHF, 36% of the patients were comanaged by a primary care physician and a cardiologist. The comanagement relationship often began early in the development of CHF, 20% at stage I and 54% at stage II. The patients who were comanaged were younger, predominately men, had a greater frequency of myocardial infarction, were more likely to have decreased systolic function, were on more cardiac medications, and had fewer hospitalizations for CHF exacerbations compared with CHF patients managed solely by family physicians. CONCLUSIONS Comanagement of patients with CHF is a common occurrence, and comanaged CHF patients have distinct characteristics from those managed solely by family physicians. These results have implications for the quality and cost of caring for patients with CHF and suggest that more detailed study is required.
Performance comparison of two text marking methods

A text document typically consists of a collection of regular structures such as words, lines, and paragraphs, a slight movement of which seems less perceptible than, say, dithering of the document image. We exploit this property to watermark formatted text documents by shifting slightly certain lines and words in order to discourage illicit distribution. We analyze two methods for reliable document identification in the presence of severe distortions introduced by photocopying, facsimile transmission, and other processing. The correlation method uses document profiles directly for detection. To eliminate the effect of certain distortions, the centroid method bases its decision on the distances between the centroids of adjacent profile blocks. We present the maximum likelihood detectors for both methods and evaluate their relative performance. Our analysis indicates that line-shift generally has a smaller error than word-shift detection, and that the correlation detector outperforms the centroid detector provided certain distortions can be accurately compensated for before detection is attempted. These results have been applied to implement a marking and identification system and preliminary experimental results have been very promising.
Granulation in livers of mice infected with Salmonella typhimurium is caused by superoxide released from host phagocytes

The pathophysiological roles of superoxide (O2.-) at the site of infection of facultative intracellular bacteria were examined in this study. To evaluate the actual in vivo generation of the superoxide, an ex vivo chemiluminescence assay was newly developed. When ICR mice were infected with a sublethal dose (8 x 10(4) CFU) of Salmonella typhimurium, the number of bacteria in the liver reached its peak at 5 days after infection (10(5.05) CFU/g of liver) and decreased thereafter. At 21 days after infection, the bacteria became undetectable. On the other hand, phorbol myristate 13-acetate-stimulated O2. - generation reached a maximum at 7 days after infection (mean photon count, 1,249 cps versus 28.8 cps before infection; n = 4) and decreased thereafter to a level similar to that before infection at 21 days after infection (28.8 cps). Histological examinations revealed that the total area of the lesions reached a peak at 7 days after infection (7.2 x 10(4) microns 2/10 visual fields). In the early phase, a microabscess with infiltration of polymorphonuclear cells was noted, and then, in the late stage, the lesion was replaced by granulation with mononuclear cell infiltration. When microscopic lesions were measured histologically, a significant correlation between the area of the lesions and phorbol myristate 13-acetate-stimulated O2. - generation was observed, which suggested that superoxide was responsible for the generation of the lesions. Modified superoxide dismutase, i.e., alpha-4-([6-(N-maleimido)hexanoyloxymethyl] cumyl)half-butyl-esterified poly(stylrene-co-malelic acid)-conjugated superoxide dismutase (SM-SOD), was then applied. When SM-SOD was administered to suppress the O2. - generation in vivo, the number of bacteria increased (10(6.1) CFU). However, the lesion formation was inhibited (total lesion area, 0.3 x 10(4) microns 2). These results suggest that the establishment of the microabscess and granuloma formation after S. typhimurium infection is not due to the bacteria per se but rather to the O2. - from the host's phagocytes. Two aspects of the O2. -, i.e., the bactericidal role and the tissue-injurious effect, were clearly demonstrated in this study. Therefore, the information obtained from these results is useful in designing treatment strategy for similar kinds of infection.
A new model of gate capacitance as a simple tool to extract MOS parameters

This paper tackles the difficult task to extract MOS parameters by a new model of the gate capacitance that takes into account both poly-Si depletion and charge quantization and includes temperature effects. A new fast and iterative procedure, based on this simplified self-consistent model, will be presented to estimate simultaneously the main MOS system parameters (oxide thickness, substrate, and poly-Si doping) and oxide field, surface potentials at the Si/SiO/sub 2/ and at the poly-Si/SiO/sub 2/ interfaces. Its effectiveness will be demonstrated by comparing oxide field and oxide thickness to those extracted by other methods proposed in the literature. Moreover, these methods are critically reviewed and we suggest improvements to reduce their errors. The agreement between CV simulation and experimental data is good without the need of any free parameter to improve the fitting quality for several gate and substrate materials combinations. Finally, a simple law to estimate substrate and poly-Si doping in n/sup +//n/sup +/ MOS capacitors from CV curves is proposed.
Relationship between Instructional Context and Views of Nature of Science

The study investigated the relationship between instructional context (integrated and non‐integrated) that explicitly teaches about nature of science (NOS) and students’ view of NOS across different disciplines. Participants were three teachers and their students, which comprised six classes of 89 ninth‐graders and 40 10th/11th‐graders. Each teacher taught two intact sections of the same grade level within a specific science discipline. The treatment for all groups involved teaching a 5–6 week unit that included the science content and NOS. The two intact groups learned about same content; the only difference was the context of NOS instruction (integrated or non‐integrated). An open‐ended questionnaire, followed by interviews, was used to assess change in participants’ views. Results showed improvement in students’ NOS views regardless of whether NOS instruction was embedded within the content. Therefore, it was not possible to make claims about whether one instructional context is more effective than another in general terms.