Miracle-dz/UniFAR-FTUs huggingface dataset:
Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians

Objective To examine the associations of a vegetarian diet and dietary fibre intake with risk of diverticular disease. Design Prospective cohort study. Setting The EPIC-Oxford study, a cohort of mainly health conscious participants recruited from around the United Kingdom. Participants 47 033 men and women living in England or Scotland of whom 15 459 (33%) reported consuming a vegetarian diet. Main outcome measures Diet group was assessed at baseline; intake of dietary fibre was estimated from a 130 item validated food frequency questionnaire. Cases of diverticular disease were identified through linkage with hospital records and death certificates. Hazard ratios and 95% confidence intervals for the risk of diverticular disease by diet group and fifths of intake of dietary fibre were estimated with multivariate Cox proportional hazards regression models. Results After a mean follow-up time of 11.6 years, there were 812 cases of diverticular disease (806 admissions to hospital and six deaths). After adjustment for confounding variables, vegetarians had a 31% lower risk (relative risk 0.69, 95% confidence interval 0.55 to 0.86) of diverticular disease compared with meat eaters. The cumulative probability of admission to hospital or death from diverticular disease between the ages of 50 and 70 for meat eaters was 4.4% compared with 3.0% for vegetarians. There was also an inverse association with dietary fibre intake; participants in the highest fifth (≥25.5 g/day for women and ≥26.1 g/day for men) had a 41% lower risk (0.59, 0.46 to 0.78; P<0.001 trend) compared with those in the lowest fifth (<14 g/day for both women and men). After mutual adjustment, both a vegetarian diet and a higher intake of fibre were significantly associated with a lower risk of diverticular disease. Conclusions Consuming a vegetarian diet and a high intake of dietary fibre were both associated with a lower risk of admission to hospital or death from diverticular disease.
Differences in FM100‐Hue test performance related to iris colour may be due to pupil size as well as presumed amounts of macular pigmentation

Background: It has been reported that the differences in macular pigment between Asian and Caucasian eyes might give rise to different performance on the Farnsworth‐Munsell 100 Hue test. However, the study did not appear to account adequately for the observation that differences were apparent only in older age groups. It was also acknowledged that other factors, like pupil size and crystalline lens colouration, could influence the result.
Inequality, Redistribution, and Economic Growth

This paper provides a critical review of the recent literature on inequality and growth. After discussing historical and more recent distributional trends as well as empirical evidence on the relationship between inequality and growth, I focus on recent explanations of the inequality-growth puzzle. I consider both the impact of the functional and the personal distribution on long-run growth rates. A final section discusses a rather neglected issue in the recent literature: the impact of expected demand for innovation decisions.
Pneumoproteins and inflammatory biomarkers in asphalt pavers

Pneumoproteins, biomarkers of systemic inflammation and endothelial activation were studied across a season in 72 asphalt pavers, 32 asphalt plant operators and 19 asphalt engineers. Smokers had lower concentrations of Clara cell protein (CC-16) and surfactant protein A, but higher concentrations of surfactant protein D, interleukin 6, C-reactive protein, fibrinogen and intercellular adhesion molecule (ICAM)-1 than non-smokers. Smokers reporting wheezing had lower mean CC-16 concentration than smokers not reporting wheezing (5.7 vs 8.6 µg l−1; p = 0.05). Cholesterol, P-selectin and ICAM-1 were lower in pavers and operators at the end compared with the start of the season. This may be related to increased physical activity during the season.
Robust stability of uncertain quantum systems

This paper considers the problem of robust stability for a class of uncertain quantum systems subject to unknown perturbations in the system Hamiltonian. Some general stability results are given for different classes of perturbations to the system Hamiltonian. Then, the special case of a nominal linear quantum system is considered with either quadratic or non-quadratic perturbations to the system Hamiltonian. In this case, robust stability conditions are given in terms of strict bounded real conditions.
Smith-Magenis Syndrome: Maladaptive Behaviors and Effects on Parent Stress, Coping, and Family Adjustment

SMITH-MAGENIS SYNDROME: MALADAPTIVE BEHAVIORS AND EFFECTS ON PARENT STRESS, COPING, AND FAMILY ADJUSTMENT Rebecca S. Morse, Ph.D. George Mason University, 2011 Dissertation Director: Dr. Johannes Rojahn Smith Magenis Syndrome (SMS) is a rare genetic syndrome most commonly caused by a microdeletion on chromosome 17 p11.2. It is associated with a pattern of physical, developmental and behavioral characteristics including intellectual disability, sleep disturbance, and a variety of behavior problems. Data were collected on 25 individuals with SMS, 10 males (mean IQ 72; SD 13), and 15 females (mean IQ 68; SD 22.2); ages 1.4-19.4 (mean 6.56; SD 4.71). Parent reports were obtained using the Vineland Adaptive Behavior Scale (VABS; Sparrow, Balla, & Cicchetti, 1984), the Achenbach Child Behavior Checklist (CBCL; Achenbach, 1991), the Family Assessment Device-General Functioning Scale (Epstein, Baldwin, & Bishop, 1983), the Family Crisis Oriented Personal Evaluation Scales (McCubin, Olson, & Larson, 1991), the Parental Stress Index-3rd edition (Abidin, 1995), and the Stress Index for Parents of Adolescents (Abidin, 1995). We found positive linear relationships between maladaptive behaviors and parent stress, but no association between maladaptive behaviors and overall life stress. We also found that parent stress levels were not associated with measures of family adjustment or specific parent coping strategies.
Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate

OBJECTIVE—Compared with nondiabetic subjects, type 2 diabetic subjects are metabolically inflexible with impaired fasting fat oxidation and impaired carbohydrate oxidation during a hyperinsulinemic clamp. We hypothesized that impaired insulin-stimulated glucose oxidation is a consequence of the lower cellular glucose uptake rate in type 2 diabetes. Therefore, we compared metabolic flexibility to glucose adjusted for glucose disposal rate in nondiabetic versus type 2 diabetic subjects and in the latter group after 1 year of lifestyle intervention (the Look AHEAD [Action For Health in Diabetes] trial). RESEARCH DESIGN AND METHODS—Macronutrient oxidation rates under fasting and hyperinsulinemic conditions (clamp at 80 mU/m2 per min), body composition (dual-energy X-ray absorptiometry), and relevant hormonal/metabolic blood variables were assessed in 59 type 2 diabetic and 42 nondiabetic individuals matched for obesity, sex, and race. Measures were repeated in diabetic participants after weight loss. RESULTS—Metabolic flexibility to glucose (change in respiratory quotient [RQ]) was mainly related to insulin-stimulated glucose disposal rate (R2 = 0.46, P < 0.0001) with an additional 3% of variance accounted for by plasma free fatty acid concentration at the end of the clamp (P = 0.03). The impaired metabolic flexibility to glucose observed in type 2 diabetic versus nondiabetic subjects (ΔRQ 0.06 ± 0.01 vs. 0.10 ± 0.01, respectively, P < 0.0001) was no longer observed after adjusting for glucose disposal rate (P = 0.19). Additionally, the increase in metabolic flexibility to glucose after weight loss was accounted for by the concomitant increase in insulin-stimulated glucose disposal rate. CONCLUSIONS—This study suggests that metabolic inflexibility to glucose in type 2 diabetic subjects is mostly related to defective glucose transport.
In Vitro and In Vivo Survival and Transit Tolerance of Potentially Probiotic Strains Carried by Artichokes in the Gastrointestinal Tract

ABSTRACT The ability of potentially probiotic strains of Lactobacillus plantarum and Lactobacillus paracasei to survive on artichokes for at least 90 days was shown. The anchorage of bacterial strains to artichokes improved their survival in simulated gastrointestinal digestion. L. paracasei IMPC2.1 was further used in an artichoke human feeding study involving four volunteers, and it was shown that the organism could be recovered from stools.
Electrophysiological Correlates of Voice Learning and Recognition

Listeners can recognize familiar human voices from variable utterances, suggesting the acquisition of speech-invariant voice representations during familiarization. However, the neurocognitive mechanisms mediating learning and recognition of voices from natural speech are currently unknown. Using electrophysiology, we investigated how representations are formed during intentional learning of initially unfamiliar voices that were later recognized among novel voices. To probe the acquisition of speech-invariant voice representations, we compared a “same sentence” condition, in which speakers repeated the study utterances at test, and a “different sentence” condition. Although recognition performance was higher for same compared with different sentences, substantial voice learning also occurred for different sentences, with recognition performance increasing across consecutive study-test-cycles. During study, event-related potentials elicited by voices subsequently remembered elicited a larger sustained parietal positivity (∼250–1400 ms) compared with subsequently forgotten voices. This difference due to memory was unaffected by test sentence condition and may thus reflect the acquisition of speech-invariant voice representations. At test, voices correctly classified as “old” elicited a larger late positive component (300–700 ms) at Pz than voices correctly classified as “new. ” This event-related potential OLD/NEW effect was limited to the same sentence condition and may thus reflect speech-dependent retrieval of voices from episodic memory. Importantly, a speech-independent effect for learned compared with novel voices was found in beta band oscillations (16–17 Hz) between 290 and 370 ms at central and right temporal sites. Our results are a first step toward elucidating the electrophysiological correlates of voice learning and recognition.
Analysis and Implementation of a Nonisolated Bidirectional DC–DC Converter With High Voltage Gain

In this paper, a nonisolated bidirectional dc-dc converter is presented. The proposed converter consists of two boost converters to enhance the voltage gain. Four power switches with their body diodes are employed in the proposed converter. Also, two inductors and a capacitor are used as passive components. The input current is divided to the inductors which causes the efficiency to be high. The voltage gain of the proposed converter is higher than the conventional cascaded bidirectional buck/boost converter (CCBC) in step-up mode. Besides, the voltage gain in step-down mode is lower than CCBC. Besides, the efficiency of the proposed converter more than CCBC while the total stress on active switches are same. The simple structure of the proposed converter causes its control to be easy. The steady-state analysis of the proposed converter is discussed in this paper thoroughly. The stress on converters' devices and the efficiency of the proposed converter and CCBC are compared in this paper. Finally, the proposed converter prototype circuit is implemented to justify the validity of the analysis.
Distance to the Object and Social Representations: Replication and Further Evidences

Abstract Distance to the object is a new approach that highlights the complex nature of the link between groups and social representations. It is composed of three elements: knowledge, involvement, and level of practices associated with the social object. This study aims to replicate a previous study that has demonstrated the validity of distance to the object in order to explore social representations of cannabis. We carried out a research on the social representations of cocaine. Respondents (n = 200) completed a questionnaire including opinions related to cocaine and constitutive elements of the distance to cocaine. The regression analysis on the representational dimensions revealed a significant effect of the distance variable on two dimensions (social facilitator, addiction and social dangerousness). The groups that were “distant” from the object showed stronger adherence to the normative component than to the functional component of SR, in opposition to those who were “close” to the object. The concept of distance to the object is thus heuristic as it offers an integrative grid of reading that permits to understand and highlight the link individuals maintain with a social representation.
Development of a solder bump technique for contacting a three-dimensional multi electrode array

Abstract The application of a solder bump technique for contacting a three-dimensional multi electrode array is presented. Solder bumping (or C4: Controlled Collapse Chip Connections, also called Flip Chip contacting) is the most suitable contacting technique available for small dimensions and large numbers of connections. Techniques adapted from the literature could successfully be scaled down to be used for 55x55 μm pads at 120 μm heart-to-heart spacing, yielding well-conducting, reasonably strong bonds.
In silico Interrogation of Insect Central Complex Suggests Computational Roles for the Ellipsoid Body in Spatial Navigation

The central complex in the insect brain is a composite of midline neuropils involved in processing sensory cues and mediating behavioral outputs to orchestrate spatial navigation. Despite recent advances, however, the neural mechanisms underlying sensory integration and motor action selections have remained largely elusive. In particular, it is not yet understood how the central complex exploits sensory inputs to realize motor functions associated with spatial navigation. Here we report an in silico interrogation of central complex-mediated spatial navigation with a special emphasis on the ellipsoid body. Based on known connectivity and function, we developed a computational model to test how the local connectome of the central complex can mediate sensorimotor integration to guide different forms of behavioral outputs. Our simulations show integration of multiple sensory sources can be effectively performed in the ellipsoid body. This processed information is used to trigger continuous sequences of action selections resulting in self-motion, obstacle avoidance and the navigation of simulated environments of varying complexity. The motor responses to perceived sensory stimuli can be stored in the neural structure of the central complex to simulate navigation relying on a collective of guidance cues, akin to sensory-driven innate or habitual behaviors. By comparing behaviors under different conditions of accessible sources of input information, we show the simulated insect computes visual inputs and body posture to estimate its position in space. Finally, we tested whether the local connectome of the central complex might also allow the flexibility required to recall an intentional behavioral sequence, among different courses of actions. Our simulations suggest that the central complex can encode combined representations of motor and spatial information to pursue a goal and thus successfully guide orientation behavior. Together, the observed computational features identify central complex circuitry, and especially the ellipsoid body, as a key neural correlate involved in spatial navigation.
The transcriptional activity of human Chromosome 22.

A DNA microarray representing nearly all of the unique sequences of human Chromosome 22 was constructed and used to measure global-transcriptional activity in placental poly(A)(+) RNA. We found that many of the known, related and predicted genes are expressed. More importantly, our study reveals twice as many transcribed bases as have been reported previously. Many of the newly discovered expressed fragments were verified by RNA blot analysis and a novel technique called differential hybridization mapping (DHM). Interestingly, a significant fraction of these novel fragments are expressed antisense to previously annotated introns. The coding potential of these novel expressed regions is supported by their sequence conservation in the mouse genome. This study has greatly increased our understanding of the biological information encoded on a human chromosome. To facilitate the dissemination of these results to the scientific community, we have developed a comprehensive Web resource to present the findings of this study and other features of human Chromosome 22 at http://array.mbb. yale.edu/chr22.
Targeting the Glutamatergic System to Treat Pathological Gambling: Current Evidence and Future Perspectives

Pathological gambling or gambling disorder has been defined by the DSM-5 as a behavioral addiction. To date, its pathophysiology is not completely understood and there is no FDA-approved treatment for gambling disorders. Glutamate is the principal excitatory neurotransmitter in the nervous system and it has been recently involved in the pathophysiology of addictive behaviors. In this paper, we review the current literature on a class of drugs that act as modulating glutamate system in PG. A total of 19 studies have been included, according to inclusion and exclusion criteria. Clinical trial and case series using glutamatergic drugs (N-acetylcysteine, memantine, amantadine, topiramate, acamprosate, baclofen, gabapentin, pregabalin, and modafinil) will be presented to elucidate the effectiveness on gambling behaviors and on the related clinical dimensions (craving, withdrawal, and cognitive symptoms) in PG patients. The results have been discussed to gain more insight in the pathophysiology and treatment of PG. In conclusion, manipulation of glutamatergic neurotransmission appears to be promising in developing improved therapeutic agents for the treatment of gambling disorders. Further studies are required. Finally, we propose future directions and challenges in this research area.
Role of Alexithymia, Anxiety, and Depression in Predicting Self-Efficacy in Academic Students

Objective. Little research is available on the predictive factors of self-efficacy in college students. The aim of the present study is to examine the role of alexithymia, anxiety, and depression in predicting self-efficacy in academic students. Design. In a cross-sectional study, a total of 133 students at Babol University of Medical Sciences (Medicine, Dentistry, and Paramedicine) participated in the study between 2014 and 2015. All participants completed the Toronto Alexithymia Scale (TAS-20), College Academic Self-Efficacy Scale (CASES), and 14 items on anxiety and depression derived from the 28 items of the General Health Questionnaire (28-GHQ). Results. Pearson correlation coefficients revealed negative significant relationships between alexithymia and the three subscales with student self-efficacy. There was no significant correlation between anxiety/depression symptoms and student self-efficacy. A backward multiple regression analysis revealed that alexithymia was a negative significant predictor of self-efficacy in academic students (B = −0.512, P < 0.001). The prevalence of alexithymia was 21.8% in students. Multiple backward logistic analysis regression revealed that number of passed semesters, gender, mother's education, father's education, and doctoral level did not accurately predict alexithymia in college students. Conclusion. As alexithymia is prevalent in college students and affects self-efficacy and academic functioning, we suggest it should be routinely evaluated by mental physicians at universities.
Grouping by Ability: A Self-Fulfilling Prophecy?

The generic term of ability grouping will be used to describe the practice where students of perceived similar achievement levels are placed in the same classroom or group. Mathematics teachers are more likely to support homogeneous grouping than their colleagues in other discipline areas. Drawing on responses of interviews with ninety-six students from Years 9 and 10 in Queensland schools, questions were posed about the effects - social, cognitive and emotional - on students who placed in ability groups. Six schools serving very different clientele were the basis of the study and relatively equal numbers of boys and girls participated. The outcomes of this study shed insights into the perceptions of young people in streamed mathematics classrooms. The comments reinforce other studies where the students who are in the upper stream are more likely to benefit from ability grouping (where there are any benefits) but those most at risk in homogeneous settings are those in the lower streams.
The audiological journey and early outcomes of twelve infants with auditory neuropathy spectrum disorder from birth to two years of age

Abstract Objective: To describe the audiological journey of a group of infants with auditory neuropathy spectrum disorder (ANSD) following the fitting of hearing aids, and to investigate the potential benefits of including cortical auditory-evoked potentials (CAEPs) and a measure of functional auditory behaviour during early audiological management. Design: Results from chart revision of estimated hearing threshold, early behavioural testing, parental observation, and functional auditory behaviour assessments were described, and compared to visual reinforcement audiometry (VRA) thresholds obtained at a mean corrected age of 10 months (SD 3). The relationship with CAEPs and functional performance was examined. Study sample: The study included 12 infants diagnosed with ANSD and fitted with amplification. Results: The estimated 4FA at a mean corrected age of four months (SD5) was within ± 10 dB of VRA results in 75% of infants when unaided and aided behavioural observation audiometry (BOA), together with unaided and aided parental observations was combined. Infants with a greater proportion of CAEPs present had higher PEACH scores. Conclusions: Delaying amplification until VRA results were available would have led to a significant period of auditory deprivation for infants in this study group. None of the assessments could accurately determine hearing thresholds when used in isolation, however when used in combination clinicians were able to obtain sufficient information to fit hearing aids early, and identify infants requiring closer monitoring.
Communication and Leadership Trustworthiness in Virtual Teams: An Empirical Comparison of the US and China

This paper examines the influence of culture, self-disclosure and communication media on perceptions of trustworthiness of the leadership of a virtual team using a massively multiplayer online game (MMOG). We obtained data from two main sources: a survey sent to the virtual team members in the US and China and archival data from the log-files of the MMOG. Based on a unique data set of 2245 participants from 319 virtual teams, this study shows that perceptions of leadership trustworthiness are affected by culture, high self-disclosure and intensive use of communication media. Furthermore, we posited and found that the relationship between two dimensions of self-disclosure and trustworthiness as well as the usage of synchronous or asynchronous communication media and trustworthiness is moderated by culture. Our study sheds light on the influence of computer-mediated communication on team leadership trustworthiness in virtual team environments and the moderating role of culture.