Miracle-dz/UniFAR-FTUs huggingface dataset:
A prospective study of childhood anxiety disorders.

OBJECTIVE To evaluate course and outcome of DSM-III-R anxiety disorders prospectively in clinically referred children. METHOD Children were blindly and repeatedly assessed with a structured diagnostic interview over a 3- to 4-year period to determine recovery from anxiety disorder and development of new psychiatric disorders. Both psychopathological (attention-deficit hyperactivity disorder, n = 50) and never psychiatrically ill (NPI, n = 83) controls served as comparison groups for children with anxiety disorders (n = 84). RESULTS The majority of children (82%) were free from their intake anxiety disorders by the end of the follow-up. Relapse of these anxiety disorders after remission was rare (8%). During follow-up, anxious children were more likely to develop new psychiatric disorders (30%), primarily new anxiety disorders (16%), than were NPI children (11% and 2%, respectively), but not psychopathological controls (42% and 10%, respectively). CONCLUSIONS Overall, results suggest a favorable outcome with respect to diagnostic status for clinically referred children with anxiety disorders. However, these children may be at risk for new psychiatric disorders over time.
Cell-Autonomous Requirement for Rx Function in the Mammalian Retina and Posterior Pituitary

Rx is a paired-like homeobox gene that is required for vertebrate eye formation. Mice lacking Rx function do not develop eyes or the posterior pituitary. To determine whether Rx is required cell autonomously in these tissues, we generated embryonic chimeras consisting of wild type and Rx−/− cells. We found that in the eye, Rx-deficient cells cannot participate in the formation of the neuroretina, retina pigment epithelium and the distal part of the optic stalk. In addition, in the ventral forebrain, Rx function is required cell autonomously for the formation of the posterior pituitary. Interestingly, Rx−/− and wild type cells segregate before the morphogenesis of these two tissues begins. Our observations suggest that Rx function is not only required for the morphogenesis of the retina and posterior pituitary, but also prior to morphogenesis, for the sorting out of cells to form distinct fields of retinal/pituitary cells.
Rapid diagnosis of Mycobacterium tuberculosis infection and drug susceptibility testing.

CONTEXT The global control of tuberculosis remains a challenge from the standpoint of diagnosis, detection of drug resistance, and treatment. This is an area of special concern to the health of women and children, particularly in regions of the world with high infant mortality rates and where women have limited access to health care. OBJECTIVE Because treatment can only be initiated when infection is detected, and is guided by the results of antimicrobial susceptibility testing, there recently has been a marked increase in the development and testing of novel assays designed to detect Mycobacterium tuberculosis complex, with or without simultaneous detection of resistance to isoniazid and/or rifampin. Both nonmolecular and molecular assays have been developed. This review will summarize the current knowledge about the use of rapid tests to detect M tuberculosis and drug resistance. DATA SOURCES Review of the most recent World Health Organization Global Tuberculosis Report, as well as selected publications in the primary research literature, meta-analyses, and review articles. CONCLUSIONS To a large extent, nonmolecular methods are refinements or modifications of conventional methods, with the primary goal of providing more rapid test results. In contrast, molecular methods use novel technologies to detect the presence of M tuberculosis complex and genes conferring drug resistance. Evaluations of molecular assays have generally shown that these assays are of variable sensitivity for detecting the presence of M tuberculosis complex, and in particular are insensitive when used with smear-negative specimens. As a group, molecular assays have been shown to be of high sensitivity for detecting resistance to rifampin, but of variable sensitivity for detecting resistance to isoniazid.
Modern breaking of Enigma ciphertexts

ABSTRACT “Breaking German Army Ciphers” is the title of a Cryptologia article from 2005, describing the lucky survival of several hundred authentic Enigma messages of World War II, and an account of a ciphertext-only cryptanalysis of a large number of these messages, leaving only a few (mostly short messages) unbroken. After reviewing the work done, and investigating the reasons for both lucky breaks and close misses, the modern ciphertext-only attack on Enigma messages is improved, especially on genuine ones with short lengths and/or many garbles. The difficulties of a proper measure for the candidate’s closeness to a plaintext are clarified. The influence on the decryption process of an empty plugboard and one with only a few correct plugs is examined. The method is extended by a partial exhaustion of the plugboard combined with an optimized hillclimbing strategy. The newly designed software succeeds in breaking formerly unbroken messages.
A Fuzzy Cellular Automata Based Shell for Modeling Urban Growth – A Pilot Application in Mesogia Area

Urban growth is a global phenomenon and one of the most important reforming processes effecting both natural and human environment through many ecological and socioeconomic aspects. Given the recent growth rates and the fact that urban society’s needs in space, services, facilities and energy, grow as it’s population increases, it is of major importance for present and future societies that urban growth occurs in an optimal way, maximizing the benefits for urban population while minimizing both economical and environmental cost.
PACE: Policy-Aware Application Cloud Embedding

The emergence of new capabilities such as virtualization and elastic (private or public) cloud computing infrastructures has made it possible to deploy multiple applications, on demand, on the same cloud infrastructure. A major challenge to achieve this possibility, however, is that modern applications are typically distributed, structured systems that include not only computational and storage entities, but also policy entities (e.g., load balancers, firewalls, intrusion prevention boxes). Deploying applications on a cloud infrastructure without the policy entities may introduce substantial policy violations and/or security holes. In this paper, we present PACE: the first systematic framework for Policy-Aware Application Cloud Embedding. We precisely define the policy-aware, cloud application embedding problem, study its complexity and introduce simple, efficient, online primal-dual algorithms to embed applications in cloud data centers. We conduct evaluations using data from a real, large campus network and a realistic data center topology to evaluate the feasibility and performance of PACE. We show that deployment in a cloud without considering in-network policies may lead to a large number of policy violations (e.g., using tree routing as a way to enforce in-network policies may observe up to 91% policy violations). We also show that our embedding algorithms are very efficient by comparing with a good online fractional embedding algorithm.
Cellular damage induced by a sequential oxidative treatment on Penicillium digitatum

Aim: To investigate the cellular damage on Penicillium digitatum produced by a sequential oxidative treatment (SOT), previously standardized in our laboratory, to prevent the conidia growth. Lethal SOT consists of 2‐min preincubation with 10 ppm NaClO followed by 2‐min incubation with 6 mmol l−1 CuSO4 and 100 mmol l−1 H2O2 at 25°C.
Host defenses in experimental scrub typhus: inflammatory response of congenic C3H mice differing at the Ric gene

Two strains of C3H mice differed in their susceptibility to lethal infection with Rickettsia tsutsugamushi strain Gilliam. Adult C3H/RV mice were markedly more resistant to lethal infection than C3H/HeDub mice, and both were histocompatible as assessed by mixed-lymphocyte cultures and graft-versus-host responses. The inflammatory response of susceptible C3H/HeDub mice to intraperitoneal infection was evident approximately 5 days postinfection, and the magnitude of the cellular influx increased until death of the animal. The inflammation consisted of an early polymorphonuclear leukocyte response, followed by a mononuclear cell influx which persisted until death of the animal. The C3H/RV mice evidenced similar kinetics of cell influx, but the inflammatory response was significantly reduced in magnitude, and the response of C3H/RV animals to Gilliam was predominantly mononuclear in nature, with little influx of polymorphonuclear leukocytes into the peritoneal cavity. C3H/RV mice were rendered susceptible to Gilliam infection by induction of a nonspecific inflammation with thioglycolate if given 3 days after infection. Conversely, treatment of C3H/HeDub mice with indomethacin, an anti-inflammatory agent, prolonged survival after infection with Gilliam. The results of this study indicate that genetic resistance to Gilliam is not due simply to a greater host response to infection or, conversely, that susceptibility is due to a host response quantitatively lacking in a cellular component necessary for antirickettsial immunity.
Effect of Water on the Consolidation of Crushed Rock Salt

The consolidation behavior of crushed rock salt, as the backfill in the under-ground disposal of nuclear waste, will be important in controlling room closure rates and local permeability. Water has a significant influence on the consolidation rates. Consolidation tests of crushed WIPP rock salt samples with water content from 0.12 to 4.72% by weight were completed under both low and high pressures. Microstructure change of the consolidated specimens due to added water was observed using a scanning electron microscope. The results show that an optimum value of water content does exist under certain pressure and temperature for the crushed rock salt to reach the fastest consolidation rate.
A comparative study on intra‐articular versus systemic gene electrotransfer in experimental arthritis

Electric pulse mediated gene transfer has been applied successfully in vivo for increasing naked DNA administration in various tissues. To achieve non‐viral gene transfer into arthritic joint tissue, we investigated the use of electrotransfer (ET). Because anti‐inflammatory cytokine strategies have proven efficient in experimental models of arthritis, we compared the therapeutic efficiency of local versus systemic delivery of the interleukin‐10 (IL‐10) using in vivo ET.
Intramuscular Hemangioma of the Head and Neck

Intramuscular hemangiomas (IMH) are uncommon tumors in the head and neck region, occurring most often in the trunk and extremities. Preoperative misdiagnosis is common because of the deep location of these tumors. Ten recent cases of head and neck IMH are presented, five of which involve the masseter muscle-the most frequent site of involvement in the head and neck. Masseter IMH occurred almost exclusively in the pediatric age group. The clinical presentation, radiographic and histologic findings, treatment, complications, and outcome of these patients are presented. The vital role of preoperative diagnosis using magnetic resonance imaging (MRI) is discussed, as well as a review of the natural history of IMH and indications for surgical intervention.
A simple motion-planning algorithm for general robot manipulators

This paper presents a simple and efficient algorithm, using configuration space, to plan collision-free motions for general manipulators. We describe an implementation of the algorithm for manipulators made up of revolute joints. The configuration-space obstacles for an n degree-of-freedom manipulator are approximated by sets of n - 1 dimensional slices, recursively built up from one dimensional slices. This obstacle representation leads to an efficient approximation of the free space outside of the configuration-space obstacles.
Transporters and Drug-Drug Interactions: Important Determinants of Drug Disposition and Effects

Uptake and efflux transporters determine plasma and tissue concentrations of a broad variety of drugs. They are localized in organs such as small intestine, liver, and kidney, which are critical for drug absorption and elimination. Moreover, they can be found in important blood-tissue barriers such as the blood-brain barrier. Inhibition or induction of drug transporters by coadministered drugs can alter pharmacokinetics and pharmacodynamics of the victim drugs. This review will summarize in particular clinically observed drug-drug interactions attributable to inhibition or induction of intestinal export transporters [P-glycoprotein (P-gp), breast cancer resistance protein (BCRP)], to inhibition of hepatic uptake transporters [organic anion transporting polypeptides (OATPs)], or to inhibition of transporter-mediated [organic anion transporters (OATs), organic cation transporter 2 (OCT2), multidrug and toxin extrusion proteins (MATEs), P-gp] renal secretion of xenobiotics. Available data on the impact of nutrition on transport processes as well as genotype-dependent, transporter-mediated drug-drug interactions will be discussed. We will also present and discuss data on the variable extent to which information on the impact of transporters on drug disposition is included in summaries of product characteristics of selected countries (SPCs). Further work is required regarding a better understanding of the role of the drug metabolism–drug transport interplay for drug-drug interactions and on the extrapolation of in vitro findings to the in vivo (human) situation.
The Impact of Different Inflow Conditions on the Wake of Horizontal Axis Wind Turbine

This study introduces a numerical investigation on the impact of different inflow atmospheric conditions on the wind turbine wakes. The effects of the inflow turbulence intensity and wind speed under thermally-stratified atmospheric boundary layer (ABL) are presented and discussed. The steady state three dimensional Reynolds-Averaged Navier–Stokes (RANS) equations are solved in the simulation, along with the Actuator Disk Method (ADM) for the turbine rotor modeling. A modified k-ε model, namely El Kasmi model, is adopted for the turbulence modulation. Further, an additional source term is added to the turbulence equations, to artificially represent the buoyancy generated turbulence, without the need to solve the energy equation. It is found that, there is a considerable effect of the different atmospheric flow properties on the wake flow behavior. Particularly, as the turbulence intensity increases, the wake recovers faster and hence, the wake deficit decreases and the available wind power in the wake region increases. Further, the wake deficits values immediately downstream the turbine are higher for the lower inflow wind speeds.
Carotid and Aortic Stiffness in Patients with Heterozygous Familial Hypercholesterolemia

Background The role of plasma cholesterol in impairing arterial function and elasticity remains unclear. We evaluated arterial stiffness, measured locally in the common carotid artery by high-resolution echo-tracking, and aortic stiffness, using carotid-femoral pulse wave velocity (PWV) (the “gold-standard” measurement of arterial stiffness), in treatment-naive patients with heterozygous familial hypercholesterolemia (FH). Methods The study included 66 patients with FH (10–66 years old) and 57 first-degree relatives without FH (11–61 years old). Carotid-femoral PWV was determined by SphygmoCor (AtCor, Australia). The parameters of carotid stiffness β-index, Peterson elastic modulus and local PWV were assessed with regard to the common carotid artery at a distance of 1cm from the bifurcation (AlokaProsound Alpha7, Japan). Results FH patients showed significantly higher β-index (6.3(4.8–8.2) vs. 5.2(4.2–6.4), p = 0.005), Ep (78(53–111) kPa vs. 62(48–79) kPa, p = 0.006), local PWV (5.4(4.5–6.4) m/c vs. 4.7(4.2–5.4) m/c, p = 0.005), but comparable values of carotid-femoral PWV (6.76(7.0–7.92) m/c vs. 6.48(6.16–7.12) m/c, p = 0.138). Carotid arteries and the aorta stiffened with age in patients with FH, but after 30 years, carotid arteries stiffened more significantly than the aorta. Conclusions Our study demonstrated that treatment-naive patients with FH had stiffer carotid arteries than their relatives, but showed no difference in aortic stiffness. We also found out that the rate of reduction of elasticity of the aorta and carotid arteries in FH patients varies: it is observed earlier in carotid arteries than in the aorta.
Emerging partnerships between mental health and law enforcement.

Police departments in the 194 U.S. cities with a population of 100,000 or more were surveyed in 1996 to identify strategies they used to obtain input from the mental health system about dealing with mentally ill persons. A total of 174 departments responded (90 percent). Ninety-six departments had no specialized response for dealing with mentally ill persons. Among the 78 departments with special programs, three basic strategies were found: a police-based specialized police response, a police-based specialized mental health response, and a mental-health-based specialized mental health response. At least two-thirds of all departments, even those with no specialized response program, rated themselves as moderately or very effective in dealing with mentally ill persons in crisis.
LARAS: Locality aware replication algorithm for the Skip Graph

Skip Graph, a member of the distributed hash table (DHT) family, has several benefits as an underlying structure in peer-to-peer (P2P) storage systems. In such systems, replication plays a key role on the system's performance. The traditional decentralized replication algorithms do not consider the locations of Skip Graph nodes in the network. Negligence of node locations in the placement of the replicas results in high access delays between the nodes and their closest replicas. This negatively affects the performance of the whole storage system. In this paper, with the aim of making Skip Graph's replication locality aware, we propose dynamic fully decentralized LARAS approach, where the data owner can replicate itself based on the system size, possible data requester nodes' set and using local information of the storage system. Our extensive performance results show that LARAS improves replication access delay of the Skip Graph based storage system about 20% and 38% in comparison to the best known decentralized counterpart in the public and private replication scenarios, respectively.
A randomized version of Ramsey's theorem

The standard randomization of Ramsey's theorem asks for a fixed graph F and a fixed number r of colors: for what densities p = p(n) can we asymptotically almost surely color the edges of the random graph G(n, p) with r colors without creating a monochromatic copy of F. This question was solved in full generality by Rödl and Ruciński [Combinatorics, Paul Erdős is eighty, vol. 1, 1993, 317–346; J Am Math Soc 8(1995), 917–942]. In this paper we consider a different randomization that was recently suggested by Allen et al. [Random Struct Algorithms, in press]. Let \documentclass{article} \usepackage{amsmath,amsfonts} \pagestyle{empty} \begin{document}${{\mathcal R}_F(n,q)}$\end{document} be a random subset of all copies of F on a vertex set Vn of size n, in which every copy is present independently with probability q. For which functions q = q(n) can we color the edges of the complete graph on Vn with r colors such that no monochromatic copy of F is contained in \documentclass{article} \usepackage{amsmath,amsfonts} \pagestyle{empty} \begin{document}${{\mathcal R}_F(n,q)}$\end{document} ? We answer this question for strictly 2‐balanced graphs F. Moreover, we combine bsts an r‐edge‐coloring of G(n, p)oth randomizations and prove a threshold result for the property that there exi such that no monochromatic copy of F is contained in \documentclass{article} \usepackage{amsmath,amsfonts} \pagestyle{empty} \begin{document}${{\mathcal R}_F(n,q)}$\end{document}. © 2012 Wiley Periodicals, Inc. Random Struct. Alg. , 2012
Graphical Condition for Identification in recursive SEM

The paper concerns the problem of predicting the e�ffect of actions or interventions on a system from a combination of (i) statistical data on a set of observed variables, and (ii) qualitative causal knowledge encoded in the form of a directed acyclic graph (DAG). The DAG represents a set of linear equations called Structural Equations Model (SEM), whose coefficients are parameters representing direct causal effects. Reliable quantitative conclusions can only be obtained from the model if the causal effects are uniquely determined by the data. That is, if there exists a unique parameterization for the model that makes it compatible with the data. If this is the case, the model is called identifi�ed. The main result of the paper is a general sufficient condition for identifi�cation of recursive SEM models.
Statin Treatment in Hypercholesterolemic Men Does Not Attenuate Angiotensin II-Induced Venoconstriction

Experimental studies suggested that statins attenuate vascular AT1 receptor responsiveness. Moreover, the augmented excessive pressor response to systemic angiotensin II infusions in hypercholesterolemic patients was normalized with statin treatment. In 12 hypercholesterolemic patients, we tested the hypothesis that statin treatment attenuates angiotensin II-mediated vasoconstriction in hand veins assessed by a linear variable differential transducer. Subjects ingested daily doses of either atorvastatin (40 mg) or positive control irbesartan (150 mg) for 30 days in a randomized and cross-over fashion. Ang II–induced venoconstriction at minute 4 averaged 59%±10% before and 28%±9% after irbesartan (mean ± SEM; P<0.05) compared to 65%±11% before and 73%±11% after 30 days of atorvastatin treatment. Plasma angiotensin levels increased significantly after irbesartan treatment (Ang II: 17±22 before vs 52±40 pg/mL after [p = 0.048]; Ang-(1–7): 18±10 before vs 37±14 pg/mL after [p = 0.002]) compared to atorvastatin treatment (Ang II: 9±4 vs 11±10 pg/mL [p = 0.40]; Ang-(1–7): 24±9 vs 32±8 pg/mL [p = 0.023]). Our study suggests that statin treatment does not elicit major changes in angiotensin II-mediated venoconstriction or in circulating angiotensin II levels whereas angiotensin-(1–7) levels increased modestly. The discrepancy between local vascular and systemic angiotensin II responses might suggest that statin treatment interferes with blood pressure buffering reflexes. Trial Registration ClinicalTrials.gov NCT00154024