Miracle-dz/UniFAR-FTUs huggingface dataset:
The Independent and Shared Mechanisms of Intrinsic Brain Dynamics: Insights From Bistable Perception

In bistable perception, constant input leads to alternating perception. The dynamics of the changing perception reflects the intrinsic dynamic properties of the “unconscious inferential” process in the brain. Under the same condition, individuals differ in how fast they experience the perceptual alternation. In this study, testing many forms of bistable perception in a large number of observers, we investigated the key question of whether there is a general and common mechanism or multiple and independent mechanisms that control the dynamics of the inferential brain. Bistable phenomena tested include binocular rivalry, vase-face, Necker cube, moving plaid, motion induced blindness, biological motion, spinning dancer, rotating cylinder, Lissajous-figure, rolling wheel, and translating diamond. Switching dynamics for each bistable percept was measured in 100 observers. Results show that the switching rates of subsets of bistable percept are highly correlated. The clustering of dynamic properties of some bistable phenomena but not an overall general control of switching dynamics implies that the brain’s inferential processes are both shared and independent – faster in constructing 3D structure from motion does not mean faster in integrating components into an objects.
Children's Learning

A model of children's strategy choices and strategy discoveries. method: A direct means for studying cognitive development. Older and younger adults' strategy choices in multiplication: Testing predictions of ASCM using the choice/no-choice method. The development of numerical estimation: Evidence for multiple representations of numerical quantity. A new field of children's learning is emerging. This new field differs from the old in recognizing that children's learning includes active as well as passive mechanisms and qualitative as well as quantitative changes. Children's learning involves substantial variability of representations and strategies within individual children as well as across different children. The path of learning involves the introduction of new approaches as well as changes in the frequency of prior ones. The rate and the breadth of learning tend to occur at a human scale, intermediate between the extremes depicted by symbolic and connectionist models. Learning has many sources; one that Editor's Note Robert S. Siegler received the Award for Distinguished Scientific Contributions. Award winners are invited to deliver an award address at the APA's annual convention. A version of this award address was delivered at the 113th annual meeting , held August 18–21, 2005, in Washington, DC. Articles based on award addresses are reviewed, but they differ from unsolicited articles in that they are expressions of the win-ners' reflections on their work and their views of the field.
Linkages Between Resources, Motivation, and Engagement in Everyday Activities

The goal of this research was to examine the linkage between personal resources, intrinsic motivation, and participation in everyday activities. It was hypothesized that the reductions in resources in later life would be associated with reduced motivation to engage in cognitively demanding activities, leading to reduction in participation in such activities in everyday life. To test this, we utilized data from the 2010 and 2012 waves of the Health and Retirement Survey. We used structural equation modeling to construct latent factors associated with health resources, cognitive resources, and intrinsic motivation. Cognitive and health resources were positively associated with intrinsic motivation, which in turn partially mediated the association between these resources and engagement in cognitively demanding everyday activities. Some variation in the fit of the model was observed across sexes, and the predictive power of the model was somewhat attenuated in the oldest old (ages 81+). The results support expectations derived from selective engagement theory (Hess, 2014), which argues that increases in the costs associated with cognitive activity in later life negatively affect the motivation to engage in these potentially beneficial activities.
Glutathionylation State of Uncoupling Protein-2 and the Control of Glucose-stimulated Insulin Secretion*

Background: Proton leak through UCP2 is modulated by glutathionylation, and UCP2 modulates GSIS. Results: Glutathionylation of UCP2 amplifies GSIS from β cells. Matrix ROS activates UCP2-desensitizing GSIS. Conclusion: Reversible glutathionylation of UCP2 aids in regulating GSIS. Significance: Findings enhance our understanding of the role of redox circuits in the modulation of GSIS. The role of reactive oxygen species (ROS) in glucose-stimulated insulin release remains controversial because ROS have been shown to both amplify and impede insulin release. In regard to preventing insulin release, ROS activates uncoupling protein-2 (UCP2), a mitochondrial inner membrane protein that negatively regulates glucose-stimulated insulin secretion (GSIS) by uncoupling oxidative phosphorylation. With our recent discovery that the UCP2-mediated proton leak is modulated by reversible glutathionylation, a process responsive to small changes in ROS levels, we resolved to determine whether glutathionylation is required for UCP2 regulation of GSIS. Using Min6 cells and pancreatic islets, we demonstrate that induction of glutathionylation not only deactivates UCP2-mediated proton leak but also enhances GSIS. Conversely, an increase in mitochondrial matrix ROS was found to deglutathionylate and activate UCP2 leak and impede GSIS. Glucose metabolism also decreased the total amount of cellular glutathionylated proteins and increased the cellular glutathione redox ratio (GSH/GSSG). Intriguingly, the provision of extracellular ROS (H2O2, 10 μm) amplified GSIS and also activated UCP2. Collectively, our findings indicate that the glutathionylation status of UCP2 contributes to the regulation of GSIS, and different cellular sites and inducers of ROS can have opposing effects on GSIS, perhaps explaining some of the controversy surrounding the role of ROS in GSIS.
Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population

Objectives Studies have revealed an inverse relationship between serum total bilirubin (TBIL) levels and coronary artery disease (CAD). This study investigated the genetic variants of four bilirubin metabolism genes — heme oxygenase-1 (HMOX1), biliverdin reductase A (BLVRA), solute carrier organic anion transporter family member 1B1 (SLCO1B1), and uridine diphosphate glycosyltransferase 1A1 (UGT1A1) — in relation to TBIL levels and CAD. Methods and results Thirty-five common single nucleotide polymorphisms (SNPs) were genotyped in 2380 unrelated Han participants who underwent angiocardiography at hospitals in Shanghai, China. Only three genetic variants — rs4399719 (UGT1A1 T-2473G), rs887829 (UGT1A1 G-364A), and rs4148323 (UGT1A1 G211A) — were associated with TBIL levels (each P<0.001). Four significant associations with CAD were detected after controlling age and the false discovery rate at 15%: the recessive effect of SNP rs887829 (UGT1A1 G-364A) [age-adjusted odds ratio (OR): 0.24; 95% confidence interval (CI): 0.10–0.60; P=0.0014] and dominant effect of rs4149013 (SLCO1B1 A-12099G) (age-adjusted OR: 0.70; 95% CI: 0.55–0.91; P=0.0069) on male CAD, and the additive effects of rs2877262 (BLVRA G+1238/in6C) (age-adjusted OR: 0.73; 95% CI: 0.59–0.89; P=0.0021) and rs2690381 (BLVRA G+2613/in6A) (age-adjusted OR: 0.70; 95% CI: 0.56–0.86; P=0.0008) on female CAD. SNPs rs2877262 and rs2690381 were both in a linkage disequilibrium block within BLVRA with r2 greater than 0.750. Correspondingly, this block was identified to be associated with female CAD. Conclusion Our study provides genetic evidences for the difference in the impact of these four bilirubin metabolism genes on TBIL levels and CAD.
Reciprocal asymmetry of SYS-1/β-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans

β-Catenins are conserved regulators of metazoan development that function with TCF DNA-binding proteins to activate transcription. In Caenorhabditis elegans, SYS-1/β-catenin and POP-1/TCF regulate several asymmetric divisions, including that of the somatic gonadal precursor cell (SGP). In the distal but not the proximal SGP daughter, SYS-1/β-catenin and POP-1/TCF transcriptionally activate ceh-22 to specify the distal fate. Here, we investigate the distribution of SYS-1/β-catenin and its regulation. Using a rescuing transgene, VNS::SYS-1, which fuses VENUS fluorescent protein to SYS-1, we find more VNS::SYS-1 in distal than proximal SGP daughters, a phenomenon we call “SYS-1 asymmetry. ” In addition, SYS-1 asymmetry is seen in many other tissues, consistent with the idea that SYS-1 regulates asymmetric divisions broadly during C. elegans development. In particular, SYS-1 is more abundant in E than MS, and SYS-1 is critical for the endodermal fate. In all cases, SYS-1 is reciprocal to POP-1 asymmetry: cells with higher SYS-1 have lower POP-1, and vice versa. SYS-1 asymmetry is controlled posttranslationally and relies on frizzled and dishevelled homologs, which also control POP-1 asymmetry. Therefore, upstream regulators modulate the SYS-1 to POP-1 ratio by increasing SYS-1 and decreasing POP-1 within the same cell. By contrast, SYS-1 asymmetry does not rely on WRM-1, which appears specialized for POP-1 asymmetry. We suggest a two-pronged pathway for control of SYS-1:POP-1, which can robustly accomplish differential gene expression in daughters of an asymmetric cell division.
Diabetic Cardiovascular Autonomic Neuropathy

One of the most overlooked of all serious complications of diabetes is cardiovascular autonomic neuropathy (CAN),1–3 which encompasses damage to the autonomic nerve fibers that innervate the heart and blood vessels, resulting in abnormalities in heart rate control and vascular dynamics.4 The present report discusses the clinical manifestations (eg, resting tachycardia, orthostasis, exercise intolerance, intraoperative cardiovascular liability, silent myocardial infarction [MI], and increased risk of mortality) in the presence of CAN. It also demonstrates that autonomic dysfunction can affect daily activities of individuals with diabetes and may invoke potentially life-threatening outcomes. Advances in technology, built on decades of research and clinical testing, now make it possible to objectively identify early stages of CAN with the use of careful measurement of autonomic function and to provide therapeutic choices that are based on symptom control and that might abrogate the underlying disorder. Little information exists as to frequency of CAN in representative diabetic populations. This is further complicated by the differences in the methodology used and the lack of standardization. Fifteen studies using different end points report prevalence rates of 1% to 90%. 1 The heterogenous methodology makes it difficult to compare epidemiology across different studies. CAN may be present at diagnosis, and prevalence increases with age, duration of diabetes, and poor glycemic control. CAN also cosegregates with distal symmetric polyneuropathy, microangiopathy, and macroangiopathy. Age, diabetes, obesity, and smoking are risk factors for reduced heart rate variability (HRV)5 in type 2 diabetes. Thus, there may be selectivity and sex-related differences among the various cardiovascular risk factors as to their influence on autonomic dysfunction.6 HbA1c, hypertension, distal symmetrical polyneuropathy, retinopathy, and exposure to hyperglycemia were shown to be risk factors for developing CAN in type 1 diabetes.7 ### Resting Tachycardia Whereas abnormalities in HRV are early findings of CAN, resting tachycardia …
Fractal Dimension of Cohesive Sediment Flocs at Steady State under Seven Shear Flow Conditions

The morphological properties of kaolin flocs were investigated in a Couette-flow experiment at the steady state under seven shear flow conditions (shear rates of 5.36, 9.17, 14, 24, 31, 41 and 53 s−1). These properties include a one-dimensional (1-D) fractal dimension (D1), a two-dimensional (2-D) fractal dimension (D2), a perimeter-based fractal dimension (Dpf) and an aspect ratio (AR). They were calculated based on the projected area (A), equivalent size, perimeter (P) and length (L) of the major axis of the floc determined through sample observation and an image analysis system. The parameter D2, which characterizes the relationship between the projected area and the length of the major axis using a power function, , increased from 1.73 ± 0.03, 1.72 ± 0.03, and 1.75 ± 0.04 in the low shear rate group (G = 5.36, 9.17, and 14 s−1) to 1.92 ± 0.03, 1.82 ± 0.02, 1.85 ± 0.02, and 1.81 ± 0.02 in the high shear rate group (24, 31, 41 and 53 s−1), respectively. The parameter D1 characterizes the relationship between the perimeter and length of the major axis by the function and decreased from 1.52 ± 0.02, 1.48 ± 0.02, 1.55 ± 0.02, and 1.63 ± 0.02 in the low shear group (5.36, 9.17, 14 and 24 s−1) to 1.45 ± 0.02, 1.39 ± 0.02, and 1.39 ± 0.02 in the high shear group (31, 41 and 53 s−1), respectively. The results indicate that with increasing shear rates, the flocs become less elongated and that their boundary lines become tighter and more regular, caused by more breakages and possible restructurings of the flocs. The parameter Dpf, which is related to the perimeter and the projected area through the function , decreased as the shear rate increased almost linearly. The parameter AR, which is the ratio of the length of the major axis and equivalent diameter, decreased from 1.56, 1.59, 1.53 and 1.51 in the low shear rate group to 1.43, 1.47 and 1.48 in the high shear rate group. These changes in Dpf and AR show that the flocs become less convoluted and more symmetrical and that their boundaries become smoother and more regular in the high shear rate group than in the low shear rate group due to breakage and possible restructuring processes. To assess the effects of electrolyte and sediment concentration, 0.1 mol/L calcium chloride (CaCl2) and initial sediment concentration from 7.87 × 10−5 to 1.57 × 10−5 were used in this preliminary study. The addition of electrolyte and increasing sediment concentration could produce more symmetrical flocs with less convoluted and simpler boundaries. In addition, some new information on the temporal variation of the median size of the flocs during the flocculation process is presented.
Does the Unfavorable Pharmacokinetic and Pharmacodynamic Profile of the iNOS Inhibitor GW273629 Lead to Inefficacy in Acute Migraine?

The objective of this study was to investigate the pharmacodynamics and pharmacokinetics of a single dose of GW273629, a selective iNOS inhibitor, given during and outside a migraine attack. GW273629 1500 mg was administered to 15 migraine patients both ictally and interictally. Nasal and exhaled nitric oxide (NO), plasma 3‐nitrotyrosine, and nitrates were measured to assess systemic NO production. In addition, pharmacokinetics and treatment response were assessed. Data are mean (95% confidence interval [CI]). Plasma 3‐nitrotyrosine was higher ictally: 11.96 (8.22, 15.71) ictally versus 2.74 (2.24, 3.24) ng/10 mg interictally (P < .0001). Exhaled and nasal NO showed a similar trend: 12.5 (6.5, 18.6) and 62.2 (41.5, 82.8) ppb ictally versus 9.9 (6.3, 13.4) ppb and 52.5 (38.5, 66.0) ppb interictally, respectively. Early absorption of GW273629 (AUC0–2 [90% CI]) was reduced by 41 (22, 55)% during an attack. There was no improvement of headache or associated symptoms. Migraine headache is associated with reduced early absorption of GW273629 and excess NO production. In this open‐label study, GW273629 was ineffective in the treatment of acute migraine.
Design and Analysis of a Data Structure for Representing Sorted Lists

In this paper we explore the use of 2-3 trees to represent sorted lists. We analyze the worst-case cost of sequences of insertions and deletions in 2-3 trees under each of the following three assumptions: (i) only insertions are performed; (ii) only deletions are performed; (iii) deletions occur only at the small end of the list and insertions occur only away from the small end. Our analysis leads to a data structure for representing sorted lists when the access pattern exhibits a (perhaps time-varying) locality of reference. This structure has many of the properties of the representation proposed by Guibas, McCreight, Plass, and Roberts [1977], but it is substantially simpler and may be practical for lists of moderate size.
Bacterial Community in Water and Air of Two Sub-Alpine Lakes in Taiwan

Very few studies have attempted to profile the microbial communities in the air above freshwater bodies, such as lakes, even though freshwater sources are an important part of aquatic ecosystems and airborne bacteria are the most dispersible microorganisms on earth. In the present study, we investigated microbial communities in the waters of two high mountain sub-alpine montane lakes—located 21 km apart and with disparate trophic characteristics—and the air above them. Although bacteria in the lakes had locational differences, their community compositions remained constant over time. However, airborne bacterial communities were diverse and displayed spatial and temporal variance. Proteobacteria, Actinobacteria, Bacteroidetes, and Cyanobacteria were dominant in both lakes, with different relative abundances between lakes, and Parcubacteria (OD1) was dominant in air samples for all sampling times, except two. We also identified certain shared taxa between lake water and the air above it. The results obtained on these communities in the present study provide putative candidates to study how airborne communities shape lake water bacterial compositions and vice versa.
Containing diffusion: the tobacco industry’s multipronged trade strategy to block tobacco standardised packaging

Objective To analyse the tobacco industry’s strategy of using trade and investment agreements to prevent the global diffusion of standardised packaging (SP) of tobacco products. Methods Review of tobacco industry documents, relevant government documents and media items. The data were triangulated and thematically analysed. Results Internal tobacco industry documents reveal that during the early 1990s, tobacco companies developed a multipronged trade strategy to prevent the global diffusion of progressive tobacco packaging and labelling proposals, including SP. This strategy consisted of (1) framing the health issue in terms of trade and investment, (2) detailing alleged legal violations concerning trade barriers, intellectual property and investment rights, (3) threatening legal suits and reputational damage, and (4) garnering third-party support. These efforts helped delay SP until 2010 when Australia became the first country to reintroduce SP proposals, followed by governments in the UK and New Zealand in 2012, Ireland in 2013 and France in 2014. Review of government documents and media sources in each of the five countries indicate the industry continues to employ this multipronged strategy throughout the SP policy’s progression. Although this strategy is tailored towards each domestic context, the overall tobacco industry’s trade strategy remains consistently focused on shifting the attention away from public health and towards the realm of trade and investment with more corporate-friendly allies. Conclusion Governments seeking to implement SP need to be prepared to resist and counter the industry’s multipronged trade strategy by avoiding trade diversions, exposing false industry legal and reputational claims, and monitoring third-party support.
Estimation of optimal consumption choice with habit formation and measurement errors using micro data

This paper investigates the existence and degree of variati on cross households and over time in the intertemporal elasticity of substitution ( IES) and the coefficient of relative risk aversion (RRA) that is generated by habit forming preferences. To do so, we develop a new nonlinear GMM estimator to investigate the pre sence of habit formation in household consumption using data from the Panel Study of I ncome Dynamics. Our method accounts for classical measurement errors in consum ption without parametric assumptions on the distribution of measurement errors. The estimation results support habit formation in food consumption. Using these estimates , w develop bounds for the expectation of the implied heterogenous intertemporal ela sticity of substitution and relative risk aversion that account for measurement errors and c ompute asymptotically valid confidence intervals on these bounds. We find that these param eters display significant variation across households and over time.
Tactile Information Transmission by 2D Stationary Phantom Sensations

A phantom sensation refers to an illusory tactile sensation perceived midway between multiple distant stimulations on the skin. Phantom sensations have been used intensively in tactile interfaces owing to their simplicity and effectiveness. Despite that, the perceptual performance of phantom sensations is not completely understood, especially for 2D cases. This work is concerned with 2D stationary phantom sensations and their fundamental value as a means for information display. In User Study 1, we quantified the information transmission capacity using an absolute identification task of 2D phantom sensations. In User Study 2, we probed the distributions of the actual perceived positions of 2D phantom sensations. The investigations included both types of phantom sensations-within and out of the body. Our results provide general guidelines as to leveraging 2D phantom sensations in the design of spatial tactile display.
CCAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner

CCAAT/enhancer-binding protein δ (C/EBPδ) recently emerged as an essential player in the inflammatory response to bacterial infections. C/EBPδ levels increase rapidly after a proinflammatory stimulus, and increasing C/EBPδ levels seem to be indispensable for amplification of the inflammatory response. Here we aimed to elucidate the role of C/EBPδ in host defense in community-acquired pneumococcal pneumonia. We show that C/EBPδ−/− mice are relatively resistant to pneumococcal pneumonia, as indicated by delayed and reduced mortality, diminished outgrowth of pneumococci in lungs, and reduced dissemination of the infection. Moreover, expression of platelet-activating factor receptor (PAFR), which is known to potentiate bacterial translocation of Gram-positive bacteria, was significantly reduced during infection in C/EBPδ−/− mice compared with WT controls. Importantly, cell stimulation experiments revealed that C/EBPδ potentiates PAFR expression induced by lipoteichoic acid and pneumococci. Thus, C/EBPδ exaggerates bacterial dissemination during Streptococcus pneumoniae-induced pulmonary infection, suggesting an important role for PAFR-dependent bacterial translocation.