Miracle-dz/UniFAR-FTUs huggingface dataset:
Deficiency in Mural Vascular Cells Coincides with Blood–Brain Barrier Disruption in Alzheimer's Disease

Neurovascular dysfunction contributes to Alzheimer's disease (AD). Cerebrovascular abnormalities and blood–brain barrier (BBB) damage have been shown in AD. The BBB dysfunction can lead to leakage of potentially neurotoxic plasma components in brain that may contribute to neuronal injury. Pericytes are integral in maintaining the BBB integrity. Pericyte‐deficient mice develop a chronic BBB damage preceding neuronal injury. Moreover, loss of pericytes was associated with BBB breakdown in patients with amyotrophic lateral sclerosis. Here, we demonstrate a decrease in mural vascular cells in AD, and show that pericyte number and coverage in the cortex and hippocampus of AD subjects compared with neurologically intact controls are reduced by 59% and 60% (P < 0.01), and 32% and 33% (P < 0.01), respectively. An increase in extravascular immunoglobulin G (IgG) and fibrin deposition correlated with reductions in pericyte coverage in AD cases compared with controls; the Pearson's correlation coefficient r for the magnitude of BBB breakdown to IgG and fibrin vs. reduction in pericyte coverage was −0.96 (P < 0.01) and −0.81 (P < 0.01) in the cortex, respectively, and −0.86 (P < 0.01) and −0.98 (P < 0.01) in the hippocampus, respectively. Thus, deficiency in mural vascular cells may contribute to disrupted vascular barrier properties and resultant neuronal dysfunction during AD pathogenesis.
The Energetic Metabolism of Societies Part I: Accounting Concepts

Based upon the currently emerging international consensus on how to account for the materials flows of industrialized countries, this article proposes methods to account for the energetic metabolism of societies. It argues that, to fully exploit the potential of the metabolism approach in the context of sustainable development, both energetic and material aspects of societal metabolism have to be taken into account. The article proposes concepts to empirically describe energy input, internal energy transformations, and energy utilization of societies by extending commonly used notions of energy statistics in a way that is compatible with current methods of materials flow analysis. Whereas energy statistics include only the energy used in technical devices for providing heat, light, mechanical work, and data processing, an accounting system for the energetic metabolism of societies should also consider flows of nutritional energy for both livestock and humans. Moreover, in assessing the energy input of a society, all inputs of energy‐rich materials (and immaterial forms of energy such as electricity and light) that cross the boundary into the biophysical structures of society should be taken into consideration, regardless of the purpose for which they are eventually used. As a consequence, an energetic metabolism accounting system treats all biomass as energy input, instead of considering only the biomass used for technical energy generation, as energy statistics do. Part II in this set of articles will apply these concepts to different modes of societal organization and explore the significance of energetic metabolism for sustainable development. In particular, it will explore the significance for policies that aim at increasing the contribution of renewable energy, especially biomass.
The Effect of Information Complexity on Analysts' Use of that Information

In this study I investigate the relation between information complexity and financial analysts' use of that information. I rank by complexity six tax‐law changes enacted by the Tax Reform Act of 1986, and then examine analysts' explicit forecasts of effective tax rates around those changes. I show that analysts' revisions of their forecasts of effective tax rates appear to impound the effects of the less complex tax‐law changes but not the more complex changes. Furthermore, as expected, if analysts assimilate less complex (but not more complex) information, the magnitude of the errors in their forecasts of effective tax rates increases with the effects of the more complex tax‐law changes, but is unrelated to the less complex changes. Taken together, these results indicate that analysts assimilate less complex information to a greater extent than they assimilate more complex information. Either analysts' abilities to incorporate specific information into their forecasts is a decreasing function of the comp.
Foreign Capital Inflows and Growth in Pakistan

Developing countries have low levels of savings and investment. As a result most developing countries have to rely on Foreign Capital Inflows (FCI) to generate sufficient saving in order to achieve high levels of growth. Pakistan is one of those countries that rely heavily on external flows to supplement their savings and accelerate economic growth. The objective of this study is to find out the effect of FCI on the growth performance of Pakistan and vice versa. As the growth rate and FCI are expected to affect each other simultaneously, the Simultaneous Equation Model is applied on the aggregate time series data for the years 1970–71 to 2000–2001 for FCI, GNP and Savings. A positive and statistically significant relationship appears between FCI and growth. Further, it can be seen that Foreign Direct Investment (FDI) in FCI is highly significant and has contributed positively in the country's economic growth. The optimal policy which follows from these results is to bring changes in the composition of FCI and preferably to encourage FDI in order to enhance economic growth with the high growth level further affect FCI positively.
Remote sensing of aerosols over land surfaces from POLDER‐ADEOS‐1 polarized measurements

The polarization measurements achieved by the POLDER instrument on ADEOS-1 are used for the remote sensing of aerosols over land surfaces. The key advantage of using polarized observations is their ability to systematically correct for the ground contribution whereas the classical approach using natural light fails. The estimation of land surface polarizing properties from POLDER has been examined in a previous paper. Here we consider how the optical thickness, δ 0 , and Angstrom exponent, α , of aerosols are derived from the polarized light backscattered by the particles. The inversion scheme is detailed and illustrative results are presented. Maps of the retrieved optical thickness allow for detection of large aerosol features and, in the case of small aerosols, the δ 0 and α retrievals are consistent with correlative ground-based measurements. However, because polarized light stems mainly from small particles, the results are biased for aerosol distributions containing coarser modes of particles. To overcome this limitation, an aerosol index defined as the product AI = δα 0 is proposed. Theoretical analysis and comparison with ground-based measurements suggest that AI is approximately the same when using δ 0 and α related to the entire aerosol size distribution or derived from the polarized light originating from the small polarizing particles alone. This invariance is specially assessed by testing the continuity of AI across coastlines, given the unbiased properties of aerosol retrieval over ocean. Although reducing the information concerning the aerosols, this single parameter allows a link between the POLDER aerosol surveys over land and ocean. POLDER aerosol index global maps enable the monitoring of major aerosol sources over continental areas.
A Spatial Model of the Impact of Bankruptcy Law on Entrepreneurship

Abstract This paper employs spatial econometrics techniques to estimate the impact of bankruptcy regulation on small firm formation. The estimation of the model is computationally challenging due to the joint appearance of a lagged endogenous variable and the unobserved heterogeneity which requires modelling of initial conditions as described in Heckman (1981). We test for the joint significance of the state dummy variables in a way that can be viewed as an interesting alternative to the Hausman procedure. This was important for our analysis since, as sometimes happens in finite samples, the estimated variance–covariance matrix was not positive semi-definite. We found that the predicted probability of starting a business is 25% higher in states with higher bankruptcy exemptions than their neighbours relative to states with lower exemptions than their neighbours. Un modèle spatial de l'impact des lois sur la faillite sur la création d'entreprises Résumé La présente communication emploie des techniques d’économétrie spatiale pour évaluer l'impact de la réglementation en matière de faillite sur la constitution de petites entreprises. L'estimation du modèle pose des difficultés sur le plan computationnel en raison de l'apparition conjointe d'une variable endogène décalée et de l'hétérogénéité non observée, qui rend nécessaire la modélisation de conditions initiales, de la façon décrite par Heckman (1981). Nous testons la signification conjointe des variables indicatrices de l’état d'une façon qui peut être considérée comme une alternative intéressante à la procédure de Hausman. Ceci était important pour notre analyse, car, comme nous le relevons parfois dans des échantillons finis, la matrice variance–covariance estimée n’était pas semi-définie positive. Nous en concluons que la probabilité prévisible du lancement d'une affaire est plus élevée de l'ordre de 25% dans les états qui appliquent des exemptions pour les faillites supérieures à celles des pays avoisinants, par rapport aux états qui appliquent des exemptions inférieures à celles de leurs voisins. Un modelo espacial del impacto de la ley de bancarrotas sobre las iniciativas empresariales Résumén Este artículo emplea técnicas de econometría espacial para estimar el impacto de las normativas de bancarrotas sobre la formación de empresas pequeñas. La valoración del modelo es computacionalmente desafiante, debido a la aparición conjunta de una variable endógena rezagada y heterogeneidad inadvertida que requieren la modelación de las condiciones iniciales, como se describe en Heckman (1981). Ensayamos la significancia conjunta de las variables de prueba estatales de una forma que puede percibirse como una alternativa interesante al procedimiento Hausman. Esto fue importante para nuestro análisis, ya que, como ocurre a veces con muestras finitas, la matriz estimada de varianza–covarianza no fue semidefinitiva positiva. Descubrimos que la probabilidad predicha de iniciar un negocio es un 25% mayor en los estados con mayores exenciones de bancarrota que sus vecinos, en relación con estados con menos exenciones que sus vecinos.
Does It Take a Village? Policing Strategies and Fear of Crime in Latin America

Abstract How can policymakers reduce public fear of crime in Latin America? This study compares the effectiveness of “zero tolerance” and community-based policing strategies in Argentina, Brazil, and Chile. At the micro level, it assesses the links between fear of crime and social identity characteristics, contextual factors, the media, community participation, and other insecurities. It finds that citizens' economic, political, and social insecurities are the main determinants of their fear of crime. At the macro level, the study compares levels of public insecurity and finds that cities that employ community-based strategies to fight crime register lower levels of public fear of crime.
Natural Disasters, Economic Development, and Humanitarian Aid

Natural disasters are one of the major problems facing humankind. Between 1980 and 2004, two million people were reported killed and five billion people cumulatively affected by around 7,000 natural disasters, according to the dataset maintained by the Centre for Research on the Epidemiology of Disasters (CRED) at University of Louvain (Belgium). The economic costs are considerable and rising. The direct economic damage from natural disasters between 1980-2004 is estimated at around $1 trillion. This paper starts by describing the incidence of natural disasters, where they strike, and their development over time. It then discusses how societal factors act to protect people from or expose them to natural hazards. The final section discusses the determinants and targets of international aid to disaster victims.
Practice Of Accounting Conservatism In MBE Firms

Managers sometimes manage earnings upward (i.e., engage in earnings management) or guide analyst forecasts downward (i.e., engage in expectation management) to meet or beat analysts’ earnings forecasts (MBE). Our results suggest that certain management behavior to achieve MBE is highly associated with firms’ level of accounting conservatism. In detail, we find that (1) the level of accounting conservatism decreases as firms achieve MBE in consecutive years, (2) engaging in earnings management to achieve MBE lowers firms’ level of conservatism, and (3) firms that achieve MBE in consecutive years (CMBE firms) whose credit rating had been elevated practice less conservative accounting implying that the MBE string itself might act as a substitute for conservative accounting in lowering firms’ cost of debt.
The context of entrepreneurship in Hong Kong

Purpose – The context of Hong Kong has nurtured numerous small‐ and medium‐sized enterprises (SMEs) in which the owner/managers have exhibited rather consistent set of characteristics over decades despite shifts in the industrial structure. The purpose of this paper is to investigate how such characteristics can sustain in different industrial environments.Design/methodology/approach – By using the competency approach on a sample of 153 SME owner/managers in the wholesale trade and IT services industries, we conducted hypothesis testing on comparing first, the overall rankings of ten competency areas for SME owner/managers, and second, the ratings of individual competency areas between the two industries.Findings – While there are consistent patterns of competencies across these two contrasting industries in Hong Kong, the owner/managers in IT services industry have significantly higher ratings in innovative, strategic and learning competencies than those in the wholesale trade industry.Research limitatio.
The role of volatility regimes on volatility transmission patterns

This paper investigates volatility transmission patterns between the US and Eurozone stock markets differentiating between low and high volatility periods which tend to be related with international crisis. Our approach let us distinguish the spillover intensities between markets in calm and crisis periods and also tests for a potential increase of market comovements during these last periods. State-Dependent Volatility Impulse-Response Functions (SD-VIRF) are also introduced considering different responses of stock markets during detected periods of high and low volatilities. The results show that volatility spillovers intensities increase during turmoil periods and it is also find an increase of conditional correlation during times of market jitters.
Extended antenatal antiretroviral use correlates with improved infant outcomes throughout the first year of life

Objectives:To evaluate the effect of extended antenatal triple antiretroviral therapy (ART) on infant outcomes. Design:Retrospective cohort study using pooled data from health clinics in Malawi and Mozambique from July 2005 to December 2009. Methods:Computerized records of 3273 HIV-infected pregnant women accessing Drug Resource Enhancement Against AIDS and Malnutrition centers were reviewed. ART regimens consisted of nevirapine-based HAART as of 14–25 weeks gestation until 6 months postpartum. Infant infection was determined at 1, 6 and 12 months of age by branched DNA. Results:A total of 3071 pregnancies resulted in 3148 live births. Lost to follow-up, infant deaths and HIV-1 infection rates at 1 and 12 months were 1.3 and 11.5, 0.8 and 6.7 and 0.8 and 2.0, respectively. Infant HIV-1-free survival at 12 months was 92.5%. Mother-to-child transmission and/or infant deaths correlated with length of maternal antenatal ART by multivariate analysis at 1, 6 and 12 months: 14% in women with more than 30 days of triple antenatal ART and 6.9% in mothers receiving at least 90 days of antenatal ART, P = 0.001. Fifty percent of 54 episodes of transmission occurred in women with higher CD4 cell counts (>350 cells/μl). Infant mortality was 67/1000, lower than background rates (78–100/1000). Growth failure (weight-for-age Z score <−2) was present in 8% of infants around birth, 6% at 6 months, 23% at 12 months (lower than country-specific rates). Conclusion:Extended antenatal ART is protective against adverse infant outcomes up to 12 months of age even in children born to mothers with higher CD4 cell counts.
Contracting with Nonfinancial Stakeholders and Corporate Capital Structure: The Case of Product Warranties

Abstract We investigate the relation between a firm’s product warranty level and its leverage. We find that leverage relates negatively to the warranty level and that this relation is robust to controls for endogeneity and self-selection into offering warranties. The negative warranty-leverage relation obtains only in the subsample of firms in the manufacturing industries. We also show that firms with warranties have the lowest debt levels, firms without warranties but operating in industries where other firms offer warranties on average carry higher debt, and firms in industries where no firm offers a warranty have the highest debt levels.
Spatio-temporal data fusion in cerebral angiography

This thesis provides a framework for generating the previously unobtained high resolution time sequences of 3D images that show the dynamics of cerebral blood flow. These sequences allow image feedback during medical procedures that can facilitate the detection and observation of stenosis, aneurysms, and clots. The 3D time series is constructed by fusing together a single static 3D image with one or more time sequence of 2D projections. The fusion process utilizes a variational approach that constrains the volumes to have both smoothly varying regions separated by edges and sparse regions of non-zero support. Results are presented on both clinical and simulated phantom data sets. The 3D time series results are visualized using the following tools: time series of intensity slices, synthetic X-rays from an arbitrary view, time series of isosurfaces, and 3D surfaces that show arrival times of contrast using color. This thesis also details the different steps needed to prepare the two classes of data. In addition to the spatio-temporal data fusion algorithm, three new algorithms are presented: a single pass groupwise registration algorithm for registering the time series, a 2D-3D registration algorithm for registering the time series with respect to the 3D volume, and a modified adaptive version of the Cusum algorithm used for determining arrival times of contrast within the 2D time sequences. Thesis Supervisor: Sanjoy K. Mitter Title: Professor Thesis Supervisor: Rami S. Mangoubi Title: Senior Member of the Technical Staff, C. S. Draper Laboratory
The Twin Deficits Problem in Sri Lanka

Many economists have argued that prolonged fiscal expansions contribute to current account imbalances. The purpose of this paper is to explore this phenomenon in the case of Sri Lanka during the period 1970 to 2003. In this study, the autoregressive distributed lag (ARDL) model and the bounds test for cointegration (Pesaran et al. 2001) were used to assess the long-run dynamics between the twin deficits in Sri Lanka. The empirical analysis in this paper supports the Keynesian view that there is a long-run relationship between current account imbalances and budget deficit. The empirical results also show that the direction of causality runs from the budget deficit to the current account deficit. Thus, any policy measures to reduce the budget deficit in Sri Lanka could well assist in reducing the current account imbalances. Strategies and policies to manage the twin-deficits are discussed in this paper.
Corporate governance and income smoothing in China

Purpose - The purpose of this paper is to examine empirically whether corporate governance mechanisms have an effect on income-smoothing behavior in the People's Republic of China. Design/methodology/approach - The sample comprises 1,358 companies listed in the Shanghai Stock Exchange and the Shenzhen Stock Market during the period 1999 to 2006. By comparing the variability of income to the variability of sales, an income smoother can be identified if income is less variable than sales. Findings - The authors' empirical results show that income smoothing is more severe when the state is the controlling shareholder of the Chinese listed firm. Firms with more independent directors are more likely to engage in income smoothing. The governance mechanisms such as board of directors, supervisory board, audit committee, external auditors, and shareholders' participation are not effective in curtailing income smoothing in China. Practical implications - For Chinese firms and especially government-linked enterprises, the way in which they present themselves may be significant, since the image they present to potential strategic partners may be marred by suspicions of income smoothing. Originality/value - The paper presents the current development of China's corporate governance system and indicates that agency conflicts between controlling shareholders and minority investors account for a significant portion of earnings management in China.
Anti-inflammatory role in septic shock of pituitary adenylate cyclase-activating polypeptide receptor

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two mediators synthesized by immune cells, specially under inflammatory and antigen stimulation conditions. Reports have shown that neuropeptides attenuate the deleterious consequences of septic shock both by down-regulating the production of proinflammatory mediators and by stimulating the production of anti-inflammatory cytokines by activated macrophages. In this study, we used a knockout for the PACAP receptor (PAC1−/−) to demonstrate an important protective role for PAC1 receptor in endotoxic shock. Moreover, our results indicate that PAC1 receptor acts in vivo as an anti-inflammatory receptor, at least in part, by attenuating lipopolysaccharide (LPS)-induced production of proinflammatory IL-6, which appears to be the main cytokine regulating the expression of the majority of the acute phase protein genes, which are an important deleterious component of septic shock. Besides, our findings point to endogenously produced VIP and PACAP as participants of the natural anti-inflammatory machinery. Because VIP and PACAP are two attractive candidates for the development of therapies against acute and chronic inflammatory diseases, septic shock, and autoimmune diseases, this paper represents a contribution to the understanding of the mechanism of action of these anti-inflammatory agents.
Fiscal equalization and regions' (un)willingness-to-tax: Evidence from Germany

Under cooperative federalism, when an identical tax tariff applies to all regions of a federation, usually redistribution rules are implemented to smooth fiscal differences. The administration of tax collection, however, is sometimes delegated to the regional level, leaving the regional administrations some discretion concerning the auditing of tax returns. Building on a stylized model, we show that under such conditions granted discretionary tax deductions at the level of tax units is positively related to state-specific marginal rates of loss (MRL), i.e., the fraction of an additional tax Euro raised in a region that the fiscal-equalization system redistributes to other jurisdictions. We empirically test the model's presumption using administrative income-tax micro data from Germany. Regression estimates comply with the implications of our model.