Miracle-dz/UniFAR-FTUs huggingface dataset:
Octamer 4 expression and lymph node metastasis in ductal carcinoma of breast: Are they associated?

Abstract Purpose: Octamer 4 (Oct-4) is a transcription factor which is required for the self-renewal and pluripotency of embryonic stem cells and germ cells. In this study, we tried to examine the association of expression of Oct-4 with lymph node metastasis in ductal carcinoma of the breast. Methods: The study was conducted on a total of 45 cases of invasive ductal carcinoma of breast, no special type. Oct-4 expression was studied on paraffin-embedded sections by immunohistochemistry. Results: Oct-4 expression was seen in 22.2% of cases. No statistically significant association was found between the expression of Oct-4 and histological type, tumor size, histological grade, and lymph node metastasis. Of Oct-4 positive tumor, 80% of cases showed lymph node metastasis, as compared to 62.85% without Oct-4 expression. However, the association was statistically insignificant. Conclusion: Oct-4 expression can be a promising biomarker of carcinogenesis, metastatic potential, and prognosis of carcinoma breast. However, the study with larger sample size is needed to establish the clinicopathological potential of this biomarker.
YAŞLI BİREYLERDE STİLOİD PROÇESİN RADYOLOJİK OLARAK DEĞERLENDİRİLMESİ

Amac: Bu cal man n amac 55 ya ve ustu bireylerde stiloid procesin (SP) uzunlu:unu ve morfolojik kalsifikasyon tiplerinin gorulme s kl : n belirleyerek, ya ve cinsiyetle olan ili kisini incelemektir. Gerec ve Yontem: Cal man n materyalini 55 ya ve ustu, 90 erkek (ya ortalamas ; 62.04±8.01) ve 99 kad n (ya ortalamas ; 61.58±7.10) hasta olmak uzere toplam 189 hastaya ait ar iv panoramik radyografiler olu turmaktad r. Radyografik de erlendirmeler; SP uzunluk olcumleri Jung ve arkada lar n n s n flamas kullan larak, morfolojik kalsifikasyon tiplerinin de:erlendirilmesi ise MacDonald-Jankowski s n flamas na gore yap lm t r. Fstatistiksel analiz icin Student t-test ve ki kare testi kullan lm t r.Bulgular: Fncelenen 189 panoramik radyografide SP uzunlu:u 28.60±12.69 mm olarak ve uzam stiloid proces gorulme s kl : %27 olarak tespit edilmi tir. Sa: taraf SP ve sol taraf SP uzunluklar ve cinsiyet aras nda istatistiksel olarak anlaml ili ki bulunmad : (p>0.05) gibi, ya ve SP uzunlu:u aras nda da istatistiksel olarak anlaml(p>0.05). SP morfolojik yap tiplerinden Tip D ve Tip E daha fazla olarak gorulurken, SPlerde izlenen morfolojik kalsifikasyon tipleri ile ya ve cinsiyet aras nda istatistiksel olarak anlaml farkl l klar bulunmam t r(p>0.05). Sonuc: Bizim cal mam z n sonuclar , 55 ya ve uzeri bireylerin panoramik radyografilerinde uzam SP ya da stilohyoid kompleksin kalsifikasyonu izlenebilen, cinsiyet ayr m gostermeyen bir bulgu oldu:unu ve morfolojik yap tipi ele al nd : nda Tip D’nin gorulme s kl : n n fazla oldu:unu gostermektedir
Linear Passive Networks With Ideal Switches: Consistent Initial Conditions and State Discontinuities

This paper studies linear passive electrical networks with ideal switches. We employ the so-called linear switched systems framework in which these circuits can be analyzed for any given switch configuration. After providing a complete characterization of admissible inputs and consistent initial states with respect to a switch configuration, the paper introduces a new state reinitialization rule that is based on energy minimization at the time of switching. This new rule is proven to be equivalent to the classical methods of Laplace transform and charge/flux conservation principle. Also we illustrate the new rule on typical examples that have been treated in the literature.
Effects of methionine and betaine supplementation on growth performance, carcase composition and metabolism of lipids in male broilers

1. This study was conducted to investigate the effects of methionine and betaine supplementation on growth performance, carcase composition and lipid metabolism in growing broilers. 2. A total of 450 commercial broilers, 22 d of age, were randomly allocated to three groups, each of which included three replicates (50 birds per replicate). The groups received the same methionine-deficient diet supplemented with 0 or 1 g/kg methionine, or 0·5 g/kg betaine, respectively. 3. Methionine and betaine supplementation significantly improved weight gain and feed conversion. Supplemental methionine and betaine also significantly increased breast muscle yield and decreased abdominal fat content. Meanwhile, addition of methionine and betaine significantly increased the contents of creatine and free carnitine in liver, the activity of hormone-sensitive lipase in abdominal fat and the concentration of free fatty acid in serum, whereas uric acid concentration in serum was significantly decreased. 4. The results of this study suggest that betaine can spare methionine in its function as an essential amino acid and is as effective as methionine in improving performance and carcase quality of growing broilers if the diet is moderately deficient in methionine. The decrease in abdominal fat may be due to the increased carnitine synthesis in liver and hormone-sensitive lipase activity in abdominal fat.
Clinical gait analysis

Technologies and techniques that have evolved to aid in the assessment of human locomotion and some of the difficulties associated with the clinical application of quantitative gait analysis are examined. The parameters used for the clinical description of gait are outlined, and examples of application of clinical gait analysis are listed. Problems encountered in measuring and assessing gait patterns are discussed. Some commercially available motion measurement systems are described. Future research directions are suggested. <<ETX>>
The Many Faces of the Subspace Theorem (after Adamczewski, Bugeaud, Corvaja, Zannier...)

During the last decade the Subspace Theorem found several quite unexpected applications, mainly in the Diophantine Analysis and in the Transcendence Theory. Among the great variety of spectacular results, I have chosen several which are technically simpler and which allow one to appreciate how miraculously does the Subspace Theorem emerge in numerous situations, implying beautiful solutions to difficult problems hardly anybody hoped to solve so easily. The three main topics discussed in this article are: the work of Adamczewski and Bugeaud on complexity of algebraic numbers; the work of Corvaja and Zannier on Diophantine equations with power sums; the work of Corvaja and Zannier on integral points on curves and surfaces, and the subsequent development due to Levin and Autissier. In particular, we give a complete proof of the beautiful theorem of Levin and Autissier: an affine surface with 4 (or more) properly intersecting ample divisors at infinity cannot have a Zariski dense set of integral points.
Unemployment in East and West Europe

Unemployment in East and West Europe In this paper, we use 1991-2005 panel data on the unemployed, vacancies, inflow into unemployment, and outflow from unemployment in five former communist economies and in the western part of Germany (a benchmark western economy) to examine the evolution of unemployment together with that of inflows into unemployment and vacancies. The comparison of the transition economies with an otherwise similar and spatially close market economy is useful because it enables us to identify the main differences and similarities in the evolution of the key variables, and thus draw conclusions as to whether different or similar factors cause high unemployment. JEL Classification: P2, J4, J6, C33
Factors Associated with Insulin Resistance among Children and Adolescents Perinatally Infected with HIV-1 in the Pediatric HIV/AIDS Cohort Study

Background/Aims: Because of prior inconsistent findings, we studied a large cohort of HIV-infected children to determine: (1) prevalence of insulin resistance (IR); (2) anthropometric and clinical correlates of IR, and (3) concomitant abnormalities of glucose tolerance. Methods: The study population consisted of 451 children from the Pediatric HIV/AIDS Cohort Study. The outcome of interest was HOMA-IR. Covariates included demographic, metabolic, growth, body composition, HIV laboratory tests, and treatment characteristics. Children meeting triggers for IR underwent oral glucose tolerance tests and hemoglobin A1c (HbA1c) measurements. Results: Among 402 children with glucose and insulin measurements, 15.2% had IR of whom 79% were pubertal. IR was associated with higher alanine aminotransferase, body mass index, and nadir CD4%, Tanner stage 5, and ever having received amprenavir. Of those with IR, three had impaired fasting glucose (IFG), three impaired glucose tolerance (IGT), one IFG and IGT, none diabetic glucose tolerance, and three HbA1c between 6.1 and 6.5%. Conclusion: In our cohort of HIV-infected adolescents, we observed a 15.2% prevalence of IR more closely linked to obesity than any other variable. This finding mirrors the high prevalence of obesity-mediated IR in American youth. However, associations with CD4 count and use of protease inhibitors may indicate some effect of HIV and/or its treatment.
A Note on the Estimation of Long-Run Relationships in Panel Equations with Cross-Section Linkages

Abstract The authors address the issue of estimation and inference in dependent nonstationary panels of small cross-section dimensions. The main conclusion is that the best results are obtained applying bootstrap inference to single-equation estimators, such as fully modified ordinary least squares and dynamic ordinary least squares. Seemingly unrelated regression estimators perform badly, or are even unfeasible, when the time dimension is not very large compared to the cross-section dimension.
The Role of Teachers' Expectations in the Association between Children's SES and Performance in Kindergarten: A Moderated Mediation Analysis

This study examines the role of teachers' expectations in the association between children's socio-economic background and achievement outcomes. Furthermore, the role of children's ethnicity in moderating this mediated relation is investigated. In the present study, 3,948 children from kindergarten are examined. Data are analysed by means of structural equation modeling. First, results show that teachers' expectations mediate the relation between children's SES and their later language and math achievement, after controlling for children's ethnicity, prior achievement and gender. This result indicates that teachers may exacerbate individual differences between children. Second, children's ethnicity moderates the mediation effect of teachers' expectations with respect to math outcomes. The role of teachers' expectations in mediating the relation between SES and math outcomes is stronger for majority children than for minority children.
Predictors of distress in amyotrophic lateral sclerosis: A systematic review

Abstract Objective Understanding of the factors that predict emotional distress in Amyotrophic Lateral Sclerosis (ALS) is limited. This systematic review critically appraised and synthesised the findings of longitudinal studies into baseline clinical, demographic, social, and psychological predictors of later emotional distress in people with ALS. Methods Medline, PsycINFO and CINAHL Plus were searched for relevant published literature from their inception until April 2018. Inclusion criteria were prospective or retrospective peer-reviewed studies, written in English, assessing baseline clinical, demographic, psychological or social predictors of emotional distress or psychological quality of life ≥1 month later in adults with ALS. Results Eight studies were included in this review. Demographic or clinical factors were investigated in seven studies, social factors in two studies, and psychological factors in three studies. There was scarce evidence that any baseline demographic or clinical factors predicted emotional distress. The only factor that consistently predicted emotional distress across multiple studies was lower social support. Mindfulness and psychological quality of life each predicted emotional distress but were only evaluated in single studies. Conclusions Further research is needed to investigate the mechanisms underlying emotional distress, particularly modifiable factors such as psychological factors, to reduce emotional distress in people with ALS.
A medical thermal imaging device for the prevention of diabetic foot ulceration

In this paper a description is given of the development, characterisation and first results of a thermal imaging device aimed at significantly reducing the incidence of diabetic foot ulceration (DFU). These devices will be used in three clinical centres and in two preliminary clinical trials. The first will be on healthy volunteers to set a robust baseline for the overall research aims and the second on >100 patients at high risk of DFU. In the second phase of the project the objective is to demonstrate significant reduction in the incidence of DFU through a comparison of the results of standard care of high risk feet with standard care plus thermal imaging.
Using Dynamic Aspects in Music Composition Systems

Aspect-oriented programming (AOP) attempts to modularise crosscutting concerns in software. Initial approaches to AOP have used static weaving techniques in which crosscutting implementation, encapsulated by aspects, is merged into . Research into dynamic aspects suggests various ways in which crosscutting implementations may be dynamically woven into code, enabling aspects to be defined and composed at run-time. It has been suggested, in [14], that AOP might be usefully applied at the end-user level in applications that support multidimensional creative processes, and in particular, of music composition. In this paper we extend this argument to suggest that dynamic aspects are essential to this application. We motivate our argument with a high-level description of crosscutting that exists within music composition, and ways in which these crosscutting concerns, and requirements for their management, have arisen from our initial use of static aspects in music composition. We then evaluate some of the ways in which current research into dynamic aspects might be utilised in addressing these requirements.
The association between periodontal disease and dementia: a systematic review and meta-analysis

Background and Objective: Periodontal disease is a chronic infection and inflammatory condition of the tooth-supporting tissues. Dementia is a degenerative condition of the brain affecting memory and brain function. The objective of this review is to evaluate associations between the two conditions. Methods: Systematic review with meta-analysis of published articles that involved participants aged ? 45 years with either periodontal disease or dementia. Electronic database searches of PubMed, Embase, Web of Science and Scopus were conducted to source articles that met the inclusion criteria. The NewcastleOttawa Scale was used for quality appraisal. Two random effects meta-analyses were conducted to investigate the bi-directional association between periodontitis and dementia. Results: Of 1,670 titles and abstracts found, quality assessment was conducted on 23 articles that met the inclusion criteria. Eight articles presenting findings on the association between dementia and periodontitis, and four studies on the converse association, were subsequently combined into meta-analysis. People with periodontal disease are more likely to suffer from dementia (Odds Ratio=1.17, 95% CI=1.02-1.34, P heterogeneity=0.33, I2 =13%). Conversely, people with dementia are 69% more likely to have periodontal disease (Odds Ratio =1.69, 95% CI=1.23-2.30, P heterogeneity=0.00, I2 =76%). Conclusion: A bi-directional association exists between periodontitis and dementia. With the aging population increasing, degenerative conditions such as dementia and periodontal disease are becoming more common. Family members and healthcare providers need to be aware that the effects of dementia may impede adequate oral hygiene, the cornerstone of prevention of periodontitis, and increase the likelihood of periodontal disease.
Energy-driven integrated hardware-software optimizations using SimplePower

With the emergence of a plethora of embedded and portable applications, energy dissipation has joined throughput, area, and accuracy/precision as a major design constraint. Thus, designers must be concerned with both optimizing and estimating the energy consumption of circuits, architectures, and software. Most of the research in energy optimization and/or estimation has focused on single components of the system and has not looked across the interacting spectrum of the hardware and software. The novelty of our new energy estimation framework, SimplePower, is that it evaluates the energy considering the system as a whole rather than just as a sum of parts, and that it concurrently supports both compiler and architectural experimentation. We present the design and use of the SimplePower framework that includes a transition-sensitive, cycle-accurate datapath energy model that interfaces with analytical and transition sensitive energy models for the memory and bus subsystems, respectively. We analyzed the energy consumption of ten codes from the multidimensional array domain, a domain that is important for embedded video and signal processing systems, after applying different compiler and architectural optimizations. Our experiments demonstrate that early estimates from the SimplePower energy estimation framework can help identify the system energy hotspots and enable architects and compiler designers to focus their efforts on these areas.
Severe obesity effect on low back biomechanical stress of manual load lifting.

BACKGROUND Little research is available on low back biomechanical stresses that obese and overweight workers experience from manual load lifting. OBJECTIVE The study objective was to quantitatively evaluate low back biomechanical stresses of severely obese (BMI≥35 kg/m2) workers during manual lifts of moderate load weights. METHOD Twenty severely obese and 20 normal weight participants performed infrequent lifting in 16 task conditions. In each task condition, NIOSH recommended load weights were computed for the origin and destination of lift and were employed as the load weights. Optical motion capture was performed to collect lifting posture data. For each participant and each lifting condition, L5/S1 disc compression forces were computed at the origin and destination of lift using a static low back biomechanical model. RESULTS The L5/S1 disc compression forces estimated for the severely obese participants ranged from 3000N to 8500N and many exceeded the 3400N NIOSH action limit by large margins. Group mean disc compression force was significantly larger for the severely obese than the normal weight group. CONCLUSION In light of previous research on spine, bone and obesity, the study results seem to suggest that severely obese individuals are likely at an increased risk of lifting-related low back pain compared with normal weight individuals.
Effects of bypass fat on postpartum reproductive performance in dairy cattle

This study was conducted to determine the effects of bypass fat on postpartum reproductive performance in dairy cattle. A total of 40 advance pregnant crossbred dairy cows of 2 to 5 parity were randomly divided into two groups, control (n=10) and treatment (n=30). The control animals were maintained on routine standard feeding schedule. The treatment animals in addition to routine standard feeding schedule, were supplemented orally daily with extra 100 g of bypass fat (Enerfat, Kemin) for about 2 weeks before expected date of calving and continued one week after calving. The level of bypass fat was then increased as per the milk production @ 10 gram per litre of milk produced until 60 days postpartum limiting to maximum of 250 gram/day. Blood samples were collected from each animal at 2 week prior to expected date of calving (-14), day 0, 10, 20 and 30 of calving, for the estimation of various blood biochemical parameters. Gross uterine involution and the interval from calving to first estrus occurrence were recorded. Bypass supplementation non-significantly reduce uterine involution time and time from calving to first postpartum observed estrus. Peripartum bypass fat supplementation significantly (P<0.05) increased serum glucose and total cholesterol but significantly (P<0.05) decreased serum (non-esterified fatty acids) NEFA level.
Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy

Calpain plays a critical role in cardiomyopathic changes in type 1 diabetes (T1D). This study investigated how calpain regulates mitochondrial reactive oxygen species (ROS) generation in the development of diabetic cardiomyopathy. T1D was induced in transgenic mice overexpressing calpastatin, in mice with cardiomyocyte-specific capn4 deletion, or in their wild-type littermates by injection of streptozotocin. Calpain-1 protein and activity in mitochondria were elevated in diabetic mouse hearts. The increased mitochondrial calpain-1 was associated with an increase in mitochondrial ROS generation and oxidative damage and a reduction in ATP synthase-α (ATP5A1) protein and ATP synthase activity. Genetic inhibition of calpain or upregulation of ATP5A1 increased ATP5A1 and ATP synthase activity, prevented mitochondrial ROS generation and oxidative damage, and reduced cardiomyopathic changes in diabetic mice. High glucose concentration induced ATP synthase disruption, mitochondrial superoxide generation, and cell death in cardiomyocytes, all of which were prevented by overexpression of mitochondria-targeted calpastatin or ATP5A1. Moreover, upregulation of calpain-1 specifically in mitochondria induced the cleavage of ATP5A1, superoxide generation, and apoptosis in cardiomyocytes. In summary, calpain-1 accumulation in mitochondria disrupts ATP synthase and induces ROS generation, which promotes diabetic cardiomyopathy. These findings suggest a novel mechanism for and may have significant implications in diabetic cardiac complications.
The risk of ischemic optic neuropathy post phacoemulsification cataract surgery

Introduction The aim was to study the risk of non arteritic ischemic optic neuropathy after phacoemulsification cataract surgery. Methods This study was conducted at King Hussein Medical Center during the period between January 2015 and July 2016. Patients attending ophthalmology clinic complaining of decreased vision due to lens opacity were evaluated. Patients were divided into two groups. First group included patients with no medical illness and second group included patients with diabetes mellitus, hypertension or hyperlipidemia. The two groups were further divided into two subgroups. First subgroup included patients who had phacoemulsification surgery and second subgroup did not have surgery. All patients were followed up for 6 months. They were assessed by neuro-ophthalmologist looking for ischemic optic neuropathy. Results A total number of 568 patients were enrolled. Group 1A included patients with no medical illness who underwent surgery and group 1B did not undergo surgery. The number of patients in these two subgroups was 119 and 103 respectively. Number of patients in group 2A (medical illness and surgery) was 188 and number of patients in group 2B (medical illness and no surgery) was 130. The incidence of ischemic optic neuropathy was 4.3 % in group 2A, 4.2 % in group 1A, 0.8% in group 2B, and 0% in group 1B. Conclusion Phacoemulsification is a risk factor for non arteritic ischemic optic neuropathy independent of the presence of medical risk factors. Suggested mechanisms would be local anaesthesia, intraocular pressure fluctuation and local intraocular inflammation.