Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulation of urokinase receptors in monocytelike U937 cells by phorbol ester phorbol myristate acetate

A specific surface receptor for urokinase plasminogen activator (uPA) recognizes the amino-terminal growth factor-like sequence of uPA, a region independent from and not required for the catalytic activity of this enzyme. The properties of the uPA receptor (uPAR) and the localization and distribution of uPA in tumor cells and tissues suggest that the uPA/uPAR interaction may be important in regulating extracellular proteolysis-dependent processes (e.g., invasion, tissue destruction). Phorbol myristate acetate (PMA), an inducer of U937 cell differentiation to macrophage-like cells, elicits a time- and concentration-dependent increase in the number of uPAR molecules as shown by binding, cross-linking, and immunoprecipitation studies. The effect of PMA is blocked by cycloheximide. Overall, the data indicate that PMA increases the synthesis of uPA. PMA treatment also causes a decrease in the affinity of the uPAR for uPA, thus uncovering another way of regulating the interaction between uPA and uPAR. In addition, the PMA treatment causes a modification of migration of the cross- linked receptor in mono- and bidimensional gel electrophoresis.
Formulation and Physical characterization of microcrystals for dissolution rate enhancement of Tolbutamide

Tolbutamide (TBM) is a first-generation sulphonylurea, used for treatment of non-insulin dependent diabetes mellitus. Tolbutamide is practically insoluble in water and its dissolution is the rate-limiting step for its absorption, which leads variable bioavailability. The aim of this investigation was to enhance the dissolution rate of Tolbutamide by formation of microcrystals using solvent change method. The in situ micronization process was carried out using solvent change method in the presence of Polyvinylpyrrolidone (PVP) as stabilizing agents that limits the size of the particles generated. TBM was dissolved in methanol and the stabilizing agent in water (as non-solvent). The non-solvent was poured rapidly into the drug solution under stirring by a magnetic stirrer, and the resultant was oven-dried. Microcrystals were characterized by optical microscopy, SEM, FTIR, DSC, XRD and in vitro powder dissolution study. TBM microcrystals showed narrow particle size and change in crystalline shape from rod-shape to. FTIR and DSC results showed no interaction between the drug and the stabilizer. XRD diffractograms of microcrystals showed smaller peak height than untreated TBM indicates that crystal habit modification occurred in the microcrystals without any polymorphic changes. Negative Gibb’s free energy change represented spontaneous solubility of microcrystals. Dissolution efficiency of TBM microcrystals at 15 min. (DE15%) was increased about 9 times. Microcrystals were found to have good flow property.
Pharmacokinetic and pharmacodynamic interactions between antiepileptics and antidepressants

Introduction: Antiepileptic–antidepressant combinations are frequently used by clinicians; their pharmacokinetic (PK) and pharmacodynamic (PD) drug interactions (DIs) have not been well studied but are frequently likely to be clinically relevant. Areas covered: This article provides a comprehensive review of PK DIs between antiepileptics and antidepressants. In the absence of PD DI studies, PD information on pharmacological mechanisms and studies on efficacy and safety of individual drugs are reviewed. Expert opinion: The clinical relevance of the inductive properties of carbamazepine, phenytoin, phenobarbital and primidone and the inhibitory properties of valproic acid and some antidepressants are well understood; correction factors are provided if appropriate DI studies have been completed. More PK studies are needed for: i) antiepileptics with potent inductive effects for all recently approved antidepressants; ii) high doses of mild CYP3A4 inducers, such as clobazam, eslicarbazepine, oxcarbazepine, rufinamide and topiramate for reboxetine and vilazodone; iii) valproate as a possible inhibitor, mild inducer or both a mild inducer and competitive inhibitor of some antidepressants; and iv) inhibitory effects of long-term fluoxetine use on clobazam, lacosamide, phenobarbital, primidone, carbamazepine, felbamate, tiagabine and zonisamide. Possible synergistic or additive beneficial PD DIs in generalized anxiety disorder, chronic pain, migraine prophylaxis, weight control and menopausal symptoms need study.
Adaptive-Rate Reconstruction of Time-Varying Signals With Application in Compressive Foreground Extraction

We propose and analyze an online algorithm for reconstructing a sequence of signals from a limited number of linear measurements. The signals are assumed sparse, with unknown support, and evolve over time according to a generic nonlinear dynamical model. Our algorithm, based on recent theoretical results for l1 - l1 minimization, is recursive and computes the number of measurements to be taken at each time on-the-fly. As an example, we apply the algorithm to online compressive video foreground extraction, a problem stated as follows: given a set of measurements of a sequence of images with a static background, simultaneously reconstruct each image while separating its foreground from the background. The performance of our method is illustrated on sequences of real images. We observe that it allows a dramatic reduction in the number of measurements or reconstruction error with respect to state-of-the-art compressive background subtraction schemes.
Chaos in Air Pollutant Concentration (APC) Time Series

Three chaotic indicators, namely the correlation dimension, the Lyapunov exponent, and the Kolmogorov entropy, are estimated for one-year long hourly average NO (nitrogen monoxide), CO (carbon monoxide), SO2 (sulfur dioxide), PM10 (particles with an aerodynamic diameter of approximately 10 μm or less), and NO2 (nitrogen dioxide) concentration to examine the possible chaotic characteristics in the air pollutant concentration (APC) time series. The presence of chaos in the examined APC time series is evident with the low correlation dimensions (3.42-4.71), the positive values of the largest Lyapunov exponent (0.128-0.427), and the positive Kolmogorov entropies (0.628-0.737). Since the existence of multifractal characteristics in the above time series has been confirmed in our previous investigations, the presence of chaotic behavior identified in the current study suggests the possibility of a chaotic multifractal approach for APC time series characterization. Some problems concerning the applicability of chaos analysis in air pollution are also discussed.
Lessons Learned from Users' Experiences with Spreadsheet Constraints in the Garnet and Amulet Graphical Toolkits

This research was supported in part by the National Science Foundation under grants CCR-9633624 and CCR-9970958. Authors’ Addresses: B. Vander Zanden, Computer Science Department, University of Tennessee, Knoxville, TN 37920, email: bvz@cs.utk. edu. R. Halterman, School of Computing, Southern Adventist University, P.O. Box 370, Collegedale, TN 37315, email: haltermn@cs.southern. edu. B. Myers and R. Miller, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, email: brad.myers, rcm@cs.cmu. edu. P. Szekely, USC/Information Sciences Institute, 4676 Admiralty Way, Marina del Rey, CA 90292, email: szekely@isi.edu. D. Giuse, Vanderbilt University Medical Center, 2209 Garland Avenue, Nashville, TN 37232-8340, email: Dario.Giuse@vanderbilt.edu. David Kosbie, Sewickley Academy, 315 Academy Avenue, Sewickley, PA 15143, email: dkosbie@yahoo.com. R. McDaniel, Siemens Technology-To-Business Center, 1995 University Avenue, Suite 375, Berkeley, CA 94704, email: richm@ttb.siemens. com.
Transcriptome Data Reveal Syndermatan Relationships and Suggest the Evolution of Endoparasitism in Acanthocephala via an Epizoic Stage

The taxon Syndermata comprises the biologically interesting wheel animals (“Rotifera”: Bdelloidea + Monogononta + Seisonidea) and thorny-headed worms (Acanthocephala), and is central for testing superordinate phylogenetic hypotheses (Platyzoa, Gnathifera) in the metazoan tree of life. Recent analyses of syndermatan phylogeny suggested paraphyly of Eurotatoria (free-living bdelloids and monogononts) with respect to endoparasitic acanthocephalans. Data of epizoic seisonids, however, were absent, which may have affected the branching order within the syndermatan clade. Moreover, the position of Seisonidea within Syndermata should help in understanding the evolution of acanthocephalan endoparasitism. Here, we report the first phylogenomic analysis that includes all four higher-ranked groups of Syndermata. The analyzed data sets comprise new transcriptome data for Seison spec. (Seisonidea), Brachionus manjavacas (Monogononta), Adineta vaga (Bdelloidea), and Paratenuisentis ambiguus (Acanthocephala). Maximum likelihood and Bayesian trees for a total of 19 metazoan species were reconstructed from up to 410 functionally diverse proteins. The results unanimously place Monogononta basally within Syndermata, and Bdelloidea appear as the sister group to a clade comprising epizoic Seisonidea and endoparasitic Acanthocephala. Our results support monophyly of Syndermata, Hemirotifera (Bdelloidea + Seisonidea + Acanthocephala), and Pararotatoria (Seisonidea + Acanthocephala), rejecting monophyly of traditional Rotifera and Eurotatoria. This serves as an indication that early acanthocephalans lived epizoically or as ectoparasites on arthropods, before their complex lifecycle with arthropod intermediate and vertebrate definite hosts evolved.
Cyclobutane pyrimidine dimer formation is a molecular trigger for solar-simulated ultraviolet radiation-induced suppression of memory immunity in humans

We tested the hypothesis that DNA is a target for solar-simulated ultraviolet radiation (ssUVR)-induced suppression of the reactivation of memory immunity in humans. T4N5 liposomes contain the DNA repair enzyme T4 endonuclease V. This cleaves DNA at the site of ultraviolet radiation (UVR)-induced cyclobutane pyrimidine dimers (CPD), initiating DNA repair. It has previously been used to show that CPDs are a key molecular trigger for UVR-induced immunosuppression in mice. To determine whether CPD formation is involved in UVR immunosuppression in humans, nickel-allergic volunteers were irradiated with a range of doses of ssUVR. T4N5 or empty liposomes were then applied after irradiation. Nickel-induced recall immunity was assessed by reflectance spectrometry. T4N5 liposomes inhibited immunosuppression and prevented ssUVR from reducing the number of epidermal dendritic cells. T4N5 liposomes also reduced macrophage infiltration into irradiated epidermis. These studies show that enhanced removal of CPDs from human skin protects from immunosuppression, hence demonstrating that these photolesions are an important molecular event in ssUVR-induced immunosuppression in humans. CPDs also triggered loss of dendritic cells and infiltration by macrophages. It is possible that these changes to antigen presenting cells contribute to ssUVR induced suppression of recall immunity to nickel in humans.
The Effects of GH Transgenic Goats on the Microflora of the Intestine, Feces and Surrounding Soil

The development of genetically engineered animals has brought with it increasing concerns about biosafety issues. We therefore evaluated the risks of growth hormone from transgenic goats, including the probability of horizontal gene transfer and the impact on the microbial community of the goats’ gastrointestinal tracts, feces and the surrounding soil. The results showed that neither the GH nor the neoR gene could be detected in the samples. Moreover, there was no significant change in the microbial community of the gastrointestinal tracts, feces and soil, as tested with PCR-denaturing gradient gel electrophoresis and 16S rDNA sequencing. Finally, phylogenetic analysis showed that the intestinal content, feces and soil samples all contained the same dominant group of bacteria. These results demonstrated that expression of goat growth hormone in the mammary of GH transgenic goat does not influence the microflora of the intestine, feces and surrounding soil.
The PKD Inhibitor CID755673 Enhances Cardiac Function in Diabetic db/db Mice

The development of diabetic cardiomyopathy is a key contributor to heart failure and mortality in obesity and type 2 diabetes (T2D). Current therapeutic interventions for T2D have limited impact on the development of diabetic cardiomyopathy. Clearly, new therapies are urgently needed. A potential therapeutic target is protein kinase D (PKD), which is activated by metabolic insults and implicated in the regulation of cardiac metabolism, contractility and hypertrophy. We therefore hypothesised that PKD inhibition would enhance cardiac function in T2D mice. We first validated the obese and T2D db/db mouse as a model of early stage diabetic cardiomyopathy, which was characterised by both diastolic and systolic dysfunction, without overt alterations in left ventricular morphology. These functional characteristics were also associated with increased PKD2 phosphorylation in the fed state and a gene expression signature characteristic of PKD activation. Acute administration of the PKD inhibitor CID755673 to normal mice reduced both PKD1 and 2 phosphorylation in a time and dose-dependent manner. Chronic CID755673 administration to T2D db/db mice for two weeks reduced expression of the gene expression signature of PKD activation, enhanced indices of both diastolic and systolic left ventricular function and was associated with reduced heart weight. These alterations in cardiac function were independent of changes in glucose homeostasis, insulin action and body composition. These findings suggest that PKD inhibition could be an effective strategy to enhance heart function in obese and diabetic patients and provide an impetus for further mechanistic investigations into the role of PKD in diabetic cardiomyopathy.
Some Monetary Facts

This article describes three long-run monetary facts derived by examining data for 110 countries over a 30-year period, using three definitions of a country’s money supply and two subsamples of countries: (1) Growth rates of the money supply and the general price level are highly correlated for all three money definitions, for the full sample of countries, and for both subsamples. (2) The growth rates of money and real output are not correlated, except for a subsample of countries in the Organisation for Economic Co-operation and Development, where these growth rates are positively correlated. (3) The rate of inflation and the growth rate of real output are essentially uncorrelated.
Embolic Protection and Platelet Inhibition During Renal Artery Stenting

Background— Preservation of renal function is an important objective of renal artery stent procedures. Although atheroembolization can cause renal dysfunction during renal stent procedures, whether adjunctive use of embolic protection devices or glycoprotein IIb/IIIa inhibitors improves renal function is unknown. Methods and Results— One hundred patients undergoing renal artery stenting at 7 centers were randomly assigned to an open-label embolic protection device, Angioguard, or double-blind use of a platelet glycoprotein IIb/IIIa inhibitor, abciximab, in a 2×2 factorial design. The main effects of treatments and their interaction were assessed on percentage change in Modification in Diet in Renal Disease–derived glomerular filtration rate from baseline to 1 month using centrally analyzed creatinine. Filter devices were analyzed for the presence of platelet-rich thrombus. With stenting alone, stenting and embolic protection, and stenting with abciximab alone, glomerular filtration rate declined (P<0.05), but with combination therapy, it did not decline and was superior to the other allocations in the 2×2 design (P<0.01). The main effects of treatment demonstrated no overall improvement in glomerular filtration rate; although abciximab was superior to placebo (0±27% versus −10±20%; P<0.05), embolic protection was not (−1±28% versus −10±20%; P=0.08). An interaction was observed between abciximab and embolic protection (P<0.05), favoring combination treatment. Abciximab reduced the occurrence of platelet-rich emboli in the filters from 42% to 7% (P<0.01). Conclusions— Renal artery stenting alone, stenting with embolic protection, and stenting with abciximab were associated with a decline in glomerular filtration rate. An unanticipated interaction between Angioguard and abciximab was seen, with combination therapy better than no treatment or either treatment alone.
Ral Overactivation in Malignant Peripheral Nerve Sheath Tumors

ABSTRACT Ras leads an important signaling pathway that is deregulated in neurofibromatosis type 1 and malignant peripheral nerve sheath tumor (MPNST). In this study, we show that overactivation of Ras and many of its downstream effectors occurred in only a fraction of MPNST cell lines. RalA, however, was overactivated in all MPNST cells and tumor samples compared to nontransformed Schwann cells. Silencing Ral or inhibiting it with a dominant-negative Ral (Ral S28N) caused a significant reduction in proliferation, invasiveness, and in vivo tumorigenicity of MPNST cells. Silencing Ral also reduced the expression of epithelial mesenchymal transition markers. Expression of the NF1-GTPase-related domain (NF1-GRD) diminished the levels of Ral activation, implicating a role for neurofibromin in regulating RalA activation. NF1-GRD treatment caused a significant decrease in proliferation, invasiveness, and cell cycle progression, but cell death increased. We propose Ral overactivation as a novel cell signaling abnormality in MPNST that leads to important biological outcomes with translational ramifications.
Modeling and Design of Fault-Tolerant and Self-Adaptive Reconfigurable Networked Embedded Systems

Automotive, avionic, or body-area networks are systems that consist of several communicating control units specialized for certain purposes. Typically, different constraints regarding fault tolerance, availability and also flexibility are imposed on these systems. In this article, we will present a novel framework for increasing fault tolerance and flexibility by solving the problem of hardware/software codesign online. Based on field-programmable gate arrays (FPGAs) in combination with CPUs, we allow migrating tasks implemented in hardware or software from one node to another. Moreover, if not enough hardware/software resources are available, the migration of functionality from hardware to software or vice versa is provided. Supporting such flexibility through services integrated in a distributed operating system for networked embedded systems is a substantial step towards self-adaptive systems. Beside the formal definition of methods and concepts, we describe in detail a first implementation of a reconfigurable networked embedded system running automotive applications.
Social encounter networks: collective properties and disease transmission

A fundamental challenge of modern infectious disease epidemiology is to quantify the networks of social and physical contacts through which transmission can occur. Understanding the collective properties of these interactions is critical for both accurate prediction of the spread of infection and determining optimal control measures. However, even the basic properties of such networks are poorly quantified, forcing predictions to be made based on strong assumptions concerning network structure. Here, we report on the results of a large-scale survey of social encounters mainly conducted in Great Britain. First, we characterize the distribution of contacts, which possesses a lognormal body and a power-law tail with an exponent of −2.45; we provide a plausible mechanistic model that captures this form. Analysis of the high level of local clustering of contacts reveals additional structure within the network, implying that social contacts are degree assortative. Finally, we describe the epidemiological implications of this local network structure: these contradict the usual predictions from networks with heavy-tailed degree distributions and contain public-health messages about control. Our findings help us to determine the types of realistic network structure that should be assumed in future population level studies of infection transmission, leading to better interpretations of epidemiological data and more appropriate policy decisions.
The Economic Burden of Traumatic Brain Injury Due to Fatal Traffic Accidents in Shahid Rajaei Trauma Hospital, Shiraz, Iran

Background: Traumatic Brain Injuries (TBIs) as a result of traffic accidents are one of the major causes of deaths, which lead to the loss of individuals’ productive and working years of life. Objectives: This study aimed to calculate the economic burden of traumatic brain injuries in fatal crashes at Shahid Rajaei Trauma Hospital, Shiraz, Iran for a period of five years. Patients and Methods: In this descriptive, cross-sectional study the population included people who had died as a result of TBIs during 2009 to 2013 in Shiraz Shahid Rajaei Trauma Hospital. Cost and demographic data were obtained from the participants’ medical records using data gathering forms, and some other information was also collected via telephone calls to the victims’ families. Economic burden of TBIs due to traffic accidents, which led to death, was estimated using the human capital as direct costs of treatment, and the number of potential years of life lost and lost productivity as indirect costs. Results: Deaths resulting from TBIs due to traffic accidents in Shiraz imposed 6.2 billion Rials (511000 USD) of hospital costs, 6390 potential years of life lost, and 506 billion Rials (20 million USD) of productivity lost. In the present study, the mean age of the individuals who died was 38.4 ± 19.41 and the productivity lost per capita was 1.8 billion Rials (73000 USD). Conclusions: The findings of this study indicated that the economic burden of TBIs was high in fatal accidents in Fars Province so that it was equivalent to 0.00011% of Iran’s Gross Domestic Product (GDP) in 2013. Therefore, more attention has to be paid to the rules to prevent the fatal accidents.
Zero-Shot Learning by Convex Combination of Semantic Embeddings

Abstract: Several recent publications have proposed methods for mapping images into continuous semantic embedding spaces. In some cases the embedding space is trained jointly with the image transformation. In other cases the semantic embedding space is established by an independent natural language processing task, and then the image transformation into that space is learned in a second stage. Proponents of these image embedding systems have stressed their advantages over the traditional \nway{} classification framing of image understanding, particularly in terms of the promise for zero-shot learning -- the ability to correctly annotate images of previously unseen object categories. In this paper, we propose a simple method for constructing an image embedding system from any existing \nway{} image classifier and a semantic word embedding model, which contains the $\n$ class labels in its vocabulary. Our method maps images into the semantic embedding space via convex combination of the class label embedding vectors, and requires no additional training. We show that this simple and direct method confers many of the advantages associated with more complex image embedding schemes, and indeed outperforms state of the art methods on the ImageNet zero-shot learning task.