Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Super Mineral Powder on Autogenous Shrinkage of Cement Paste

The paper investigates the effect of super mineral powder on Autogenous shrinkage of cement paste. Two multiplex Admixture is mixed into cement paste respectively.Effect of super mineral powder is invest- gated by estimating the samples of different SF/FA(the ratio of mass of SF to FA)and GBS/FA(the ratio of mass of GBS to FA). It is found that fly Ash(FA)reduce Autogenous shrinkage,silica fume(SF)and ground granulated blast furnace slag(GBS)increases Autogenous shrinkage.Autogenous shrinkage is remarkably rela- tive to SF/FA or GBS/FA remarkable.
Expression of TIM-3 on Plasmacytoid Dendritic Cells as a Predictive Biomarker of Decline in HIV-1 RNA Level during ART

Depletion and functional impairment of circulating plasmacytoid dendritic cells (pDCs) are characteristic attributes of HIV-1-infection. The mechanism of dysfunction of pDCs is unclear. Here, we studied the development of phenotype of pDCs in a cohort of HIV-1-infected individuals monitored before the initiation and during a 9-month follow up with antiretroviral therapy (ART). Using polychromatic flow cytometry, we detected significantly higher pDC-surface expression of the HIV-1 receptor CD4, regulatory receptor BDCA-2, Fcγ receptor CD32, pDC dysfunction marker TIM-3, and the marker of killer pDC, TRAIL, in treatment-naïve HIV-1-infected individuals before initiation of ART when compared to healthy donors. After 9 months of ART, all of these markers approached but did not reach the expression levels observed in healthy donors. We found that the rate of decline in HIV-1 RNA level over the first 3 months of ART negatively correlated with the expression of TIM-3 on pDCs. We conclude that immunogenic phenotype of pDCs is not significantly restored after sustained suppression of HIV-1 RNA level in ART-treated patients and that the level of the TIM-3 expressed on pDCs in treatment naïve patients could be a predictive marker of the rate of decline in the HIV-1 RNA level during ART.
Image Classification using non-linear Support Vector Machines on Encrypted Data

In image processing, algorithms for object classification are typically based around machine learning. From the algorithm developer’s perspective, these can involve a considerable amount of effort and expertise to develop, which makes them commercially valuable. On the other hand, other parties may want to make use of these algorithms to classify their images, while protecting the privacy of their data. In this paper, we show how non-linear Support Vector Machines (SVMs) can be practically used for image classification on data encrypted with a Somewhat Homomorphic Encryption (SHE) scheme. Previous work has shown how an SVM with a linear kernel can be computed on encrypted data, but this only has limited applicability. By enabling SVMs with polynomial kernels, a much larger class of applications are possible with more accuracy in classification results.
Early Tomographic Changes in the Eyes of Patients With Keratoconus.

PURPOSE To identify tomographic variables best suited for detecting keratoconus before manifestation of ectatic changes and showing disease progression in the early stage. METHODS Twenty-seven patients with diagnosed unilateral keratoconus were followed up for their fellow eye, which had not yet shown any ectatic changes, to determine initial change indicators toward keratoconus disease. Variables were compared to 50 normal eyes without any known disease. A following receiver operating characteristic (ROC) analysis was performed to reveal the variables best used to discriminate healthy eyes from early ectatic eyes. RESULTS The calculated mean difference of the cylinder for total corneal refractive power was only 0.07 ± 0.32 diopters (D) (anterior astigmatism = 0.12 ± 0.28 D and posterior astigmatism = 0.02 ± 0.10 D). ROC revealed the index of height decentration with an area under the curve of 0.788 ± 0.054 as the most suitable to differentiate between eyes of healthy patients and the non-ectatic eye of patients with asymmetrical keratoconus, followed by the index of vertical asymmetry of 0.772 ± 0.057 and a keratoconus index of 0.743 ± 0.062. However, with progression of the eyes into early ectactic stages, the ROC showed the highest area under the curve for D-index (0.876 ± 0.039), followed by index of height decentration (0.855 ± 0.046) and index of vertical asymmetry (0.842 ± 0.046). CONCLUSIONS Early stages of keratoconus are hard to diagnose and best results can be achieved by using index of height decentration and index of vertical asymmetry. As the disease progresses, D-index is better suited to diagnose an ectasia. Astigmatism, keratometry, and pachymetry barely change in the early stages, so these values are not as fitting as corneal elevation parameters for early diagnosis. [J Refract Surg. 2018;34(4):254-259. ].
Clinical implications of Plasmodium resistance to atovaquone/proguanil: a systematic review and meta-analysis

Abstract Background Atovaquone/proguanil, registered as Malarone®, is a fixed-dose combination recommended for first-line treatment of uncomplicated Plasmodium falciparum malaria in non-endemic countries and its prevention in travellers. Mutations in the cytochrome bc1 complex are causally associated with atovaquone resistance. Methods This systematic review assesses the clinical efficacy of atovaquone/proguanil treatment of uncomplicated malaria and examines the extent to which codon 268 mutation in cytochrome b influences treatment failure and recrudescence based on published information. Results Data suggest that atovaquone/proguanil treatment efficacy is 89%–98% for P. falciparum malaria (from 27 studies including between 18 and 253 patients in each case) and 20%–26% for Plasmodium vivax malaria (from 1 study including 25 patients). The in vitro P. falciparum phenotype of atovaquone resistance is an IC50 value >28 nM. Case report analyses predict that recrudescence in a patient presenting with parasites carrying cytochrome b codon 268 mutation will occur on average at day 29 (95% CI: 22, 35), 19 (95% CI: 7, 30) days longer than if the mutation is absent. Conclusions Evidence suggests atovaquone/proguanil treatment for P. falciparum malaria is effective. Late treatment failure is likely to be associated with a codon 268 mutation in cytochrome b, though recent evidence from animal models suggests these mutations may not spread within the population. However, early treatment failure is likely to arise through alternative mechanisms, requiring further investigation.
Evaluating Cultural Competence of Pediatric Oncology Nurses at a Teaching Hospital: A Pilot Study

This cross-sectional descriptive study evaluated registered nurses’ self-ratings of cultural competence on the hematology/oncology unit at a large Northeastern urban children’s hospital. The Inventory for Assessing the Process of Cultural Competence among Healthcare Professionals was used to measure 5 constructs of cultural competence. The study findings show that there were significant correlations between the knowledge and skill subscales (ρ = .57, P < .001) and the knowledge and desire subscales (ρ = .42, P < .05). The highest mean among the 5 subscales was cultural desire (mean = 15.5), indicating that nurses were motivated to engage in the process of becoming culturally competent. The lowest mean among the 5 subscales was cultural knowledge (mean = 11.2), followed by cultural skill (mean = 11.8), indicating that nurses did not perceive themselves to be well informed in these areas. The findings from this pilot study suggest that nurses on this pediatric oncology unit are most likely to possess cultural desire and cultural awareness, but there is certainly opportunity to engage and educate the staff. Targeted interventions to improve cultural competence on this inpatient unit are being explored and a larger scale study is being planned to assess the cultural competence of nurses across the hospital.
Influence of surfactants on tribological behaviors of MWCNTs (multi-walled carbon nano-tubes)

Multi-Walled Carbon Nano-Tubes (MWCNTs) are employed as anti-wear and anti-friction additives in mineral oil. The MWCNTs are known for their superior thermal conductivity, mechanical and optical properties. It is expected that hollow-core carbon nano-tubes provide easy sliding as well as rotating action with respect to one another; therefore, there is a need to explore the use of MWCNT as lubricant additive. In the present research work, experimental investigations have been conducted to explore the importance of the MWCNTs as additives in the lubricating oils. Tests were performed on three oil samples: Sample 1 (Base oil), Sample 2 (MWCNT with base oil) and Sample 3 (MWCNT and surfactant with base oil), by employing block on disc set-up. To understand the role of surfactant on MWCNT towards reducing the friction and wear, sensitivity analysis performed using fractional factorial table has been detailed. The results of cumulative wear and friction have been reported in this study.
Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI)

Background: The association of cognitive and motor impairments in Alzheimer’s disease and other neurodegenerative diseases is thought to be related to damage in the common brain networks shared by cognitive and cortical motor control processes. These common brain networks play a pivotal role in selecting movements and postural synergies that meet an individual’s needs. Pathology in this “highest level” of motor control produces abnormalities of gait and posture referred to as highest-level gait disorders. Impairments in cognition and mobility, including falls, are present in almost all neurodegenerative diseases, suggesting common mechanisms that still need to be unraveled. Objective: To identify motor-cognitive profiles across neurodegenerative diseases in a large cohort of patients. Methods: Cohort study that includes up to 500 participants, followed every year for three years, across five neurodegenerative disease groups: Alzheimer’s disease/mild cognitive impairment, frontotemporal degeneration, vascular cognitive impairment, amyotrophic lateral sclerosis, and Parkinson’s disease. Gait and balance will be assessed using accelerometers and electronic walkways, evaluated at different levels of cognitive and sensory complexity, using the dual-task paradigm. Results: Comparison of cognitive and motor performances across neurodegenerative groups will allow the identification of motor-cognitive phenotypes through the standardized evaluation of gait and balance characteristics. Conclusions: As part of the Ontario Neurodegenerative Research Initiative (ONDRI), the gait and balance platform aims to identify motor-cognitive profiles across neurodegenerative diseases. Gait assessment, particularly while dual-tasking, will help dissect the cognitive and motor contribution in mobility and cognitive decline, progression to dementia syndromes, and future adverse outcomes including falls and mortality.
Single-Frequency Integrated Ring Laser for Application in Optical Gyroscope Systems

In this letter, a monolithically integrated ring laser is demonstrated and discussed with respect of potential application in optical gyroscope systems. The device has been realized using generic indium phosphide technology and fabricated on a multi-project wafer. The laser design uses a racetrack resonator with an arrayed waveguide grating as an intra-cavity wavelength filter. Measurement results proved the on-chip laser power of ca. 10 mW and single frequency operation with side mode suppression ratio over 50 dB. The laser is integrated with an interferometric detection circuit for monitoring the beating signal under rotation of the device.
Swimming and running: a study of the convergence in long bone morphology among semi-aquatic mustelids (Carnivora: Mustelidae)

The shape of long bones is linked to a species' ecology and is thought to reflect the constraints imposed by locomo-tion. The evolution of the shape of the long bones in semi-aquatic mustelids has likely been shaped by the divergent mechanical properties of both water and land. Adaptation to a semi-aquatic lifestyle occurred independently in otters (Lutrinae) and minks (Mustelinae). Here we test the idea that these similar locomotor constraints led to morphological convergence between minks and otters, and between European and American minks. We use 3D geometric morphometrics to quantify shape differences in the humerus, radius, ulna, femur, tibia and fibula of ten species of mustelids belonging to the Lutrinae and Mustelinae subfamilies. Our results show convergence in all bones between the European and American minks, but this convergence is significant only for the humerus. We suggest that this strong convergence in humeral shape between the two minks results from functional demands on the forelimb as it produces most of the thrust when swimming in minks. The American minks show a slight but nonsignificant convergence with the Lutrinae for the shape of the ulna, femur and tibia. The sea otter (Enhydra lutris) shows an ulnar and radial shape that diverges from that observed in the other Lutrinae, possibly due to the strong manipulative abilities and unique locomotor mode of this species. In contrast to our initial hypothesis, bone shape in minks does not converge significantly with that of otters. Otters show a large variety of shapes suggesting that a semi-aquatic lifestyle can comprise a wide array of locomotor behaviours.
Neural and cognitive characteristics of extraordinary altruists

Significance Altruism, and particularly costly altruism toward strangers, such as altruistic kidney donation, represents a puzzling phenomenon for many fields of science, including evolutionary biology, psychology, and economics. How can such behavior be explained? The propensity to engage in costly altruism varies widely and may be genetically mediated, but little is known about the neural mechanisms that support it. We used structural and functional brain imaging to compare extraordinary altruists, specifically altruistic kidney donors, and controls. Altruists exhibited variations in neural anatomy and functioning that represent the inverse of patterns previously observed in psychopaths, who are unusually callous and antisocial. These findings suggest extraordinary altruism represents one end of a caring continuum and is supported by neural mechanisms that underlie social and emotional responsiveness. Altruistic behavior improves the welfare of another individual while reducing the altruist’s welfare. Humans’ tendency to engage in altruistic behaviors is unevenly distributed across the population, and individual variation in altruistic tendencies may be genetically mediated. Although neural endophenotypes of heightened or extreme antisocial behavior tendencies have been identified in, for example, studies of psychopaths, little is known about the neural mechanisms that support heightened or extreme prosocial or altruistic tendencies. In this study, we used structural and functional magnetic resonance imaging to assess a population of extraordinary altruists: altruistic kidney donors who volunteered to donate a kidney to a stranger. Such donations meet the most stringent definitions of altruism in that they represent an intentional behavior that incurs significant costs to the donor to benefit an anonymous, nonkin other. Functional imaging and behavioral tasks included face-emotion processing paradigms that reliably distinguish psychopathic individuals from controls. Here we show that extraordinary altruists can be distinguished from controls by their enhanced volume in right amygdala and enhanced responsiveness of this structure to fearful facial expressions, an effect that predicts superior perceptual sensitivity to these expressions. These results mirror the reduced amygdala volume and reduced responsiveness to fearful facial expressions observed in psychopathic individuals. Our results support the possibility of a neural basis for extraordinary altruism. We anticipate that these findings will expand the scope of research on biological mechanisms that promote altruistic behaviors to include neural mechanisms that support affective and social responsiveness.
Association Between TERT rs2736098 Polymorphisms and Cancer Risk-A Meta-Analysis

Background: Cancer remains a leading cause of death and constitutes an enormous burden on society worldwide. The association between the human telomerase reverse transcriptase (TERT) gene variant rs2736098 polymorphisms and cancer predisposition remain inconclusive. Objective and methods: Databases including Pubmed and Embase were systematically searched from inception to September 15, 2017 to retrieve studies investigating the association between the TERT variant rs2736098 polymorphisms and cancer risk in accordance with previously determined exclusion and inclusion criteria. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were evaluated using random or fixed effects models. Results: Thirty-one case-control studies from 29 articles with 15,837 cases and 19,263 controls were screened out after a systematic search. Pooled analysis demonstrated that the TERT variant rs2736098 G > A polymorphism was significantly correlated with cancer risk in all populations (A vs. G: OR = 1.134, 95% CI = 1.051–1.224, P = 0.001; AA vs. GG: OR = 1.280, 95% CI = 1.087–1.508, P = 0.003; GA vs. GG: OR = 1.125, 95% CI = 1.020–1.240, P = 0.018; GA/AA vs. GG: OR = 1.159, 95% CI = 1.047–1.283, P = 0.004). In the subgroup analysis based on cancer type, the TERT rs2736098 with the A allele was 1.299 times more frequent than that with the G allele (OR = 1.299, 95% CI = 1.216–1.386) under the allelic genetic model in lung cancer, and 1.152 times (OR = 1.152, 95% CI = 1.032–1.286) that in bladder cancer. Conclusions: This meta-analysis demonstrated significant correlations between the TERT variant rs2736098 polymorphisms and cancer susceptibility. The A allele in the rs2736098 G > A polymorphism contributes to susceptibility in many types of cancer, especially lung cancer and bladder cancer.
Emergent Leadership Structures in Informal Groups: A Dynamic, Cognitively Informed Network Model

This paper advances novel theory and evidence on the emergence of informal leadership networks in groups that feature no formally designated leaders or authority hierarchies. We integrate insights from relational schema and network theory to develop and empirically test a three-step process model. The model’s first hypothesis is that people use a “linear ordering schema” to process information about leadership relations. The second hypothesis argues that when an individual experiences a particular leadership attribution to be inconsistent with the linear ordering schema, that individual will tend to reduce the ensuing cognitive inconsistency by modifying that leadership attribution. Finally, the third hypothesis builds on this inconsistency-reduction mechanism to derive implications about a set of network structural features (asymmetry, acyclicity, transitivity, popularity, and inverse popularity) that are predicted to emerge endogenously as a group’s informal leadership network evolves. We find broad sup.
Growth response of the freshwater prawn Macrobrachium malcolmsonii (juveniles) to isocaloric diets with variable protein levels.

A B S T R A C T Indoor culture of freshwater prawn is considered to be an alternative and sustainable approach in order to meet the market demand. Culture potential of freshwater prawn (Macrobrachium malcolmsonii) under laboratory conditions was determined by growth trials performed in glass aquaria. The dietary protein requirement of M. malcolmsonii juveniles was analyzed using rations based on fish meal and shrimp meal as the main sources of protein. Five protein levels T1 (30%), T2 (32.5%), T3 (35%), T4 (37.5%) and T5 (40%) were tested to assess the best growth. Overall maximum growth was observed in T3 while minimum growth was observed in T4. Significantly higher (p<0.05) average weight, % weight gain and SGR was observed in T2 and T3 diets as compared to T1, T4 and T5 diets. Feed conversion ratio was significantly lower (p<0.05) in T2 and T3and but significantly higher (p˂0.05) in T1, T4 and T5. Water quality parameters like dissolved oxygen, ammonia, nitrate, and nitrite were recorded to be within the permissible limits while temperature, pH, alkalinity and hardness were found to be slightly higher than the permissible limits.
Recent developments and challenges in flame retardation of textiles and fibres

Almost 50 years ago, the 1950-1960 period witnessed the development of the chemistry underlying most of today's successful and durable flame retardant treatments for fibres and textiles. In today's more critical markets in terms of environmental sustainability, chemical toxicological acceptability, performance and cost, many of these are now being questioned. "Are there potential replacements for established, durable formaldehyde-based flame retardants such as those based on tetrakis (hydroxylmethyl) phosphonium salt and alkyl-substituted, N-methylol phosphonopropionamide chemistries for cellulosic textiles? " is an often-asked question. "Can we produce char-forming polyester flame retardants? " and "Can we really produce effective halogen-free replacements for coatings and back-coated textiles? " are others. These questions are addressed initially within the context of a historical review of research undertaken in the second half of the twentieth century which is the basis of most currently available, commercialised flame retardant fibres and textiles. Secondly, research reported during the first decade of the twenty first century and which primarily addresses the current issues of environmental sustainability and the search for alternative flame retardant solutions, the need to increase char-forming character in synthetic fibres and the current interest in nanotechnology are critically discussed. The possible roles of micro- and nano-surface treatments of fibre surfaces and their development using techniques such as plasma technology and layer-by-layer and sol gel chemistries are also reviewed.
Disease-modifying treatments for early and advanced multiple sclerosis: a new treatment paradigm

Purpose of review The treatment of multiple sclerosis is evolving rapidly with 11 classes of disease-modifying therapies (DMTs). This article provides an overview of a new classification system for DMTs and treatment paradigm for using these DMTs effectively and safely. Recent findings A summary of research into the use of more active approaches to early and effective treatment of multiple sclerosis with defined treatment targets of no evident disease activity (NEDA). New insights are discussed that is allowing the field to begin to tackle more advanced multiple sclerosis, including people with multiple sclerosis using wheelchairs. However, the need to modify expectations of what can be achieved in more advanced multiple sclerosis are discussed; in particular, the focus on neuronal systems with reserve capacity, for example, upper limb, bulbar and visual function. Summary The review describes a new more active way of managing multiple sclerosis and concludes with a call to action in solving the problem of slow adoption of innovations and the global problem of untreated, or undertreated, multiple sclerosis.