Miracle-dz/UniFAR-FTUs huggingface dataset:
Hydroxypropyl-β-cyclodextrin hybrid nanogels as nano-drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies

The purpose of this study was to develop and characterize hydroxypropyl-β-cyclodextrin (HPβCD) hybrid nanogels for solubility enhancement of lipophilic drug, dexibuprofen. HPβCD hybrid nanogels were designed by chemical cross-linking of hydroxypropyl-β-cyclodextrin with 2-acrylamido-2-methyl propane sulfonic acid (AMPS) via free radical polymerization. Loading efficiency, solubilization, zetasizer, FESEM Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), powder X-ray diffraction (PXRD), and in vitro drug release analysis were performed for characterization of hybrid nanogels. Efficient solubilization of dexibuprofen has been observed by HPβCD hybrid nanogels. FTIR, TGA, and DSC studies confirmed the formation of new hybrid nanogels and complexation of dexibuprofen with nanogels. XRD analysis revealed loss of dexibuprofen crystallinity in hybrid nanogels. Highly porous and amorphous nanogels showed a significant dexibuprofen release in aqueous medium. In toxicity studies, no significant changes in behavioral, physiological, biochemical, or histopathological parameters of animals endorsed that developed formulations are nontoxic and biocompatible.
Intraductal papillary mucinous neoplasms of the pancreas: Clinical association with KRAS

Intraductal papillary mucinous neoplasms of the pancreas (IPMN) are among the most important precancerous lesions in the pancreas. V-Ki-ras 2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is one of the most important genes involved in pancreatic neoplasms, and exhibits a high mutation rate in pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasia. The present study aimed to further elucidate the associations among IPMN subtypes (gastric, intestinal, pancreatobiliary and oncocytic), pathological classifications [low-grade, intermediate-grade, and high-grade IPMN, and associated minimally invasive carcinoma (invasive depth ≤0.5 cm) and advanced invasive carcinoma (invasive depth >0.5 cm)]. A total of 56 cases of IPMN were studied using scorpion amplified refractory mutation system analysis of KRAS mutations, pathological features and prognosis. KRAS mutations were identified in 50% (28/56 cases). The frequency was 60% (9/15 cases) in gastric-type, 52.6% (10/19 cases) in intestinal-type, 47.3% (9/19 cases) in pancreatobiliary-type and zero (0/3 cases) in oncocytic-type IPMN. Except for oncocytic type IPMN, the frequencies of KRAS mutations in IPMN with low, intermediate and high grade, and IPMN-associated carcinoma were 58.3% (7/12 cases), 27.3% (3/11 cases), 80% (4/5 cases) and 56% (14/25 cases), respectively. With more advanced dysplasia and invasion, the prevalence of KRAS mutations in intestinal-type IPMN increased (P=0.012). The Kaplan-Meier survival curve demonstrated that survival rate was not associated with KRAS mutation (log-rank test; P=0.308). The prevalence of KRAS mutations was lowest in intestinal-type IPMN, and was in proportion to the degree of dysplasia and invasion. Therefore, KRAS mutation in IPMN does not correlate with histological subtype, dysplasia grade, depth of invasion or survival.
Short text contextualization in information retrieval : application to tweet contextualization and automatic query expansion. (Contextualisation de textes courts pour la recherche d'information : application à la contextualisation de tweets et à l'expansion automatique de requêtes)

The efficient communication tends to follow the principle of the least effort. According to this principle, using a given language interlocutors do not want to work any harder than necessary to reach understanding. This fact leads to the extreme compression of texts especially in electronic communication, e.g. microblogs, SMS, search queries. However, sometimes these texts are not self-contained and need to be explained since understanding them requires knowledge of terminology, named entities or related facts. The main goal of this research is to provide a context to a user or a system from a textual resource.The first aim of this work is to help a user to better understand a short message by extracting a context from an external source like a text collection, the Web or the Wikipedia by means of text summarization. To this end we developed an approach for automatic multi-document summarization and we applied it to short message contextualization, in particular to tweet contextualization. The proposed method is based on named entity recognition, part-of-speech weighting and sentence quality measuring. In contrast to previous research, we introduced an algorithm for smoothing from the local context. Our approach exploits topic-comment structure of a text. Moreover, we developed a graph-based algorithm for sentence reordering. The method has been evaluated at INEX/CLEF tweet contextualization track. We provide the evaluation results over the 4 years of the track. The method was also adapted to snippet retrieval. The evaluation results indicate good performance of the approach.
Noninvasive Real-Time Characterization of Renal Clearance Kinetics in Diabetic Mice after Receiving Danshensu Treatment

Danshensu (DSS) is an active ingredient extracted from the root of the Danshen that could ameliorate oxidative stress via upregulation of heme oxygenase- (HO-) 1. Little is known about the treatment effects of DSS on kidney function in diabetic mice. Therefore, the primary aim of the present study was to characterize the renal clearance kinetics of IRdye800CW in db/db mice after DSS treatment. The secondary aim was to measure several biomarkers of renal function and oxidative stress (urinary F2-isoprostane, HO-1 in kidney and serum bilirubin). Fourteen db/db diabetic mice were randomly assigned into two groups and received either DSS treatment (DM + DSS) or vehicle treatment (DM). A third group that comprised of db/+ nondiabetic mice (non-DM control) received no DSS treatment and served as the nondiabetic control. At the end of a 3-week intervention period, serum and urinary biomarkers of renal function and oxidative stress were assessed and the renal clearance of IRdye800CW dye in all mice was determined noninvasively using Multispectral Optoacoustic Tomography. The major finding from this study suggested that DSS treatment in db/db mice improved renal clearance. Increased expression of HO-1 after DSS treatment also suggested that DSS might represent a potential therapeutic avenue for clinical intervention in diabetic nephropathy.
Distributed PID Control for Consensus and Synchronization of Multi-agent Networks

We investigate the use of distributed PID actions to achieve consensus and synchronization in networks of homogeneous and heterogeneous agents. We first analyze the case of distributed PID control on networks with heterogeneous nodes described by first-order linear systems. Convergence of the strategy is proved using appropriate state transformations and Lyapunov functions. Then, we propose a multiplex proportional-integral approach, for solving consensus problems in networks of heterogeneous n-dimensional node dynamics affected by constant disturbances. The proportional and integral actions are deployed on two different layers across the network, each with its own topology. Furthermore, the contribution of the network topology and node dynamics have been systematically separated giving some sufficient conditions guaranteeing convergence. Finally, an extension to networks of identical nonlinear node dynamics is presented. We provide local and global stability analysis together with a detailed performance assessment where heterogeneity among nodes and disturbances are considered. The effectiveness of the theoretical results is illustrated via its application to a representative power grid model recently presented in the literature and also for synchronization in networks of chaotic circuits. CHAPTER
The  $N$ -Player Trust Game and its Replicator Dynamics

Trust is a fundamental concept that underpins the coherence and resilience of social systems and shapes human behavior. Despite the importance of trust as a social and psychological concept, the concept has not gained much attention from evolutionary game theorists. In this letter, an N-player trust-based social dilemma game is introduced. While the theory shows that a society with no untrustworthy individuals would yield maximum wealth to both the society as a whole and the individuals in the long run, evolutionary dynamics show this ideal situation is reached only in a special case when the initial population contains no untrustworthy individuals. When the initial population consists of even the slightest number of untrustworthy individuals, the society converges to zero trusters, with many untrustworthy individuals. The promotion of trust is an uneasy task, despite the fact that a combination of trusters and trustworthy trustees is the most rational and optimal social state. This letter presents the game and results of replicator dynamics in a hope that researchers in evolutionary games see opportunities in filling this critical gap in the literature.
A Priori Estimates for Two-Dimensional Water Waves with Angled Crests

We consider the two-dimensional water wave problem in the case where the free interface of the fluid meets a vertical wall at a possibly non-right angle; and where the free interface can be non-$C^1$ with angled crests. We assume that the air has density zero, the fluid is inviscid, incompressible, irrotational, and subject to the gravitational force, and the surface tension is zero. In this regime, only a degenerate Taylor stability criterion $-\frac{\partial P}{\partial \bf {n}} \ge 0$ holds, with degeneracies at the singularities on the interface and at the point where it meets the wall if the angle is non-right. We construct a low-regularity energy functional and prove an a priori estimate. Our estimate differs from existing work in that it doesn't require a positive lower bound for $-\frac{\partial P}{\partial \bf{n}}$.
The design and development of a production prototype balance belt

This paper discusses the development of a balance device from lab to clinic/home use. An emerging practice among physical therapists in balance training and falls prevention addresses a major health problem in the United States: imbalance and its consequences. The annual cost for treating balance disorders exceeds $1 billion, not including the cost to treat falls. We aim to develop a non-invasive device worn around the waist. It detects when a person is tipping too far in any direction and vibrates on that side, signaling the wearer to stay within their limits of stability. Because this new technology gets a patient to a higher level of function in a shorter number of trials, it offers an opportunity to advance rehabilitation by enabling more effective outcomes for the same number of treatment sessions.
OrcFS

In this work, we develop the Orchestrated File System (OrcFS) for Flash storage. OrcFS vertically integrates the log-structured file system and the Flash-based storage device to eliminate the redundancies across the layers. A few modern file systems adopt sophisticated append-only data structures in an effort to optimize the behavior of the file system with respect to the append-only nature of the Flash memory. While the benefit of adopting an append-only data structure seems fairly promising, it makes the stack of software layers full of unnecessary redundancies, leaving substantial room for improvement. The redundancies include (i) redundant levels of indirection (address translation), (ii) duplicate efforts to reclaim the invalid blocks (i.e., segment cleaning in the file system and garbage collection in the storage device), and (iii) excessive over-provisioning (i.e., separate over-provisioning areas in each layer). OrcFS eliminates these redundancies via distributing the address translation, segment cleaning (or garbage collection), bad block management, and wear-leveling across the layers. Existing solutions suffer from high segment cleaning overhead and cause significant write amplification due to mismatch between the file system block size and the Flash page size. To optimize the I/O stack while avoiding these problems, OrcFS adopts three key technical elements. First, OrcFS uses disaggregate mapping, whereby it partitions the Flash storage into two areas, managed by a file system and Flash storage, respectively, with different granularity. In OrcFS, the metadata area and data area are maintained by 4Kbyte page granularity and 256Mbyte superblock granularity. The superblock-based storage management aligns the file system section size, which is a unit of segment cleaning, with the superblock size of the underlying Flash storage. It can fully exploit the internal parallelism of the underlying Flash storage, exploiting the sequential workload characteristics of the log-structured file system. Second, OrcFS adopts quasi-preemptive segment cleaning to prohibit the foreground I/O operation from being interfered with by segment cleaning. The latency to reclaim the free space can be prohibitive in OrcFS due to its large file system section size, 256Mbyte. OrcFS effectively addresses this issue via adopting a polling-based segment cleaning scheme. Third, the OrcFS introduces block patching to avoid unnecessary write amplification in the partial page program. OrcFS is the enhancement of the F2FS file system. We develop a prototype OrcFS based on F2FS and server class SSD with modified firmware (Samsung 843TN). OrcFS reduces the device mapping table requirement to 1/465 and 1/4 compared with the page mapping and the smallest mapping scheme known to the public, respectively. Via eliminating the redundancy in the segment cleaning and garbage collection, the OrcFS reduces 1/3 of the write volume under heavy random write workload. OrcFS achieves 56% performance gain against EXT4 in varmail workload.
Parenting styles, family structure and adolescent dietary behaviour

Abstract Objective To examine associations between parenting styles, family structure and aspects of adolescent dietary behaviour. Design Cross-sectional study. Setting Secondary schools in the East Midlands, UK. Subjects Adolescents aged 12–16 years (n 328, 57 % boys) completed an FFQ assessing their consumption of fruit, vegetables, unhealthy snacks and breakfast. Adolescents provided information on parental and sibling status and completed a seventeen-item instrument measuring the general parenting style dimensions of involvement and strictness, from which four styles were derived: indulgent, neglectful, authoritarian, authoritative. Results After controlling for adolescent gender and age, analysis of covariance revealed no significant interactions between parenting style and family structure variables for any of the dietary behaviours assessed. Significant main effects for family structure were observed only for breakfast consumption, with adolescents from dual-parent families (P < 0·01) and those with no brothers (P < 0·05) eating breakfast on more days per week than those from single-parent families and those with one or more brother, respectively. Significant main effects for parenting style were observed for all dietary behaviours apart from vegetable consumption. Adolescents who described their parents as authoritative ate more fruit per day, fewer unhealthy snacks per day, and ate breakfast on more days per week than those who described their parents as neglectful. Conclusions The positive associations between authoritative parenting style and adolescent dietary behaviour transcend family structure. Future research should be food-specific and assess the efficacy of strategies promoting the central attributes of an authoritative parenting style on the dietary behaviours of adolescents from a variety of family structures.
Epidemiology of Non-Morbid Vertebro-Medullary Trauma Following Road Accidents in the Forensic Casuistry of Bihor County, Romania

Introduction: Vertebro-medullary trauma and spinal cord injuries are a traumatic pathology commonly encountered in road accidents. The severity of the posttraumatic consequences is given by the magnitude of the meningo-medullary injuries and it is directly proportional to them. Material and Method: A retrospective study on living persons of Bihor County was conducted at the Bihor County Forensic Service, Romania. It consisted of examining forensic documents regarding vertebro-medullary trauma caused by road accidents from the Bihor County Forensic Service archive during 2013-2015. After classifying the descriptive parameters, the obtained data was statistically analyzed and the final results were presented using tables and graphs. Results and Discussions: A quarter of the road accidents occurred in Bihor County during 2013-2015 lead to vertebro-medullary trauma. Mostly, these road accidents occurred in the urban environment, during summer, on Mondays and Sundays, the victims being young male adults. The most exposed category of road traffic participants to spinal trauma is represented by passengers of four-wheeled vehicles (more often driver and the passenger on the right front place) followed by pedestrians. The vertebro-medullary injuries frequently involved the cervical segment, followed by the thoracic and lumbosacral segments, the spine having more frequently a unique lesion. The most noticed mechanism of lesions encountered is hyperextension/hyperflexia. Only one third of the study group had lesions of low intensity, the other cases being of medium or high severity with less or more sever neurological and vegetative symptoms associated. Conclusions: Vertebro-medullary trauma is a major cause of tetraparesis and paraplegia, representing a public health issue. Correct and prompt diagnosis of spinal cord injuries is essential for a favorable prognosis. It is necessary to improve the measures of preventing road accidents.
Vaccine-associated feline sarcoma: current perspectives

Feline injection site sarcomas (FISS; also known as vaccine-associated sarcomas) have been recognized for >20 years. Although uncommon, these tumors are iatrogenic, and vaccination against rabies and feline leukemia virus is perhaps the most common inciting cause. The exact etiopathogenesis is unknown, but it is widely accepted that inflammation induced by vaccines or other injections likely plays a critical role in tumor development. Injection site sarcomas are extremely locally invasive. Multimodal therapy, incorporating combinations of surgery, radiation therapy, and sometimes chemotherapy or immunotherapy, is recommended. However, tumor recurrences are common even with aggressive treatment, and many cats with FISS ultimately succumb to this devastating disease. While vaccination protocols play an important role in the management and control of infectious disease, veterinarians must be diligent in following established vaccination guidelines to minimize individual patient risk of FISS development. Early tumor detection and client education are also vital in the successful treatment of FISS.
Chiral-reversing vortex radiation from a single emitter by eigenstates phase locking

The radiation of an emitter does not depend only on its intrinsic properties but also on the surrounding photonic environment, the notion of which is essential in the developments of lasers, quantum optics and other light-matter interaction related fields. However, in conventional wisdom, an emitter radiates into photonic eigenstates in the weak coupling regime and does not alter the property of the latter. Here, we report a counterintuitive phenomenon where the radiation field of a dipole in a parity-time symmetric ring resonator displays the opposite handedness to the eigenstates of the system. This chiral-reversing radiation takes place at an exception point of the underlying non-Hermitian system, where the singularity at the exceptional point forces a phase locking of the coalesced eigenstates when interacting with the dipole emitter. Such an intriguing phenomenon has been employed to construct vortex radiation with controllable topological charge from a single quantum dot embedded plasminic nanocavity with Purcell enhancement factor up to 1000. Our scheme enriches the interesting physics of an exception point in the quantum region and may open a new paradigm for chiral quantum optics and vortex lasers at nanoscale.
RPC53 encodes a subunit of Saccharomyces cerevisiae RNA polymerase C (III) whose inactivation leads to a predominantly G1 arrest

RPC53 is shown to be an essential gene encoding the C53 subunit specifically associated with yeast RNA polymerase C (III). Temperature-sensitive rpc53 mutants were generated and showed a rapid inhibition of tRNA synthesis after transfer to the restrictive temperature. Unexpectedly, the rpc53 mutants preferentially arrested their cell division in the G1 phase as large, round, unbudded cells. The RPC53 DNA sequence is predicted to code for a hydrophilic M(r)-46,916 protein enriched in charged amino acid residues. The carboxy-terminal 136 amino acids of C53 are significantly similar (25% identical amino acid residues) to the same region of the human BN51 protein. The BN51 cDNA was originally isolated by its ability to complement a temperature-sensitive hamster cell mutant that undergoes a G1 cell division arrest, as is true for the rpc53 mutants.
Meta-analysis without study-specific variance information: Heterogeneity case

The random effects model in meta-analysis is a standard statistical tool often used to analyze the effect sizes of the quantity of interest if there is heterogeneity between studies. In the special case considered here, meta-analytic data contain only the sample means in two treatment arms and the sample sizes, but no sample standard deviation. The statistical comparison between two arms for this case is not possible within the existing meta-analytic inference framework. Therefore, the main objective of this paper is to estimate the overall mean difference and associated variances, the between-study variance and the within-study variance, as specified as the important elements in the random effects model. These estimators are obtained using maximum likelihood estimation. The standard errors of the estimators and a quantification of the degree of heterogeneity are also investigated. A measure of heterogeneity is suggested which adjusts the original suggested measure of Higgins’ I2 for within study sample size. The performance of the proposed estimators is evaluated using simulations. It can be concluded that all estimated means converged to their associated true parameter values, and its standard errors tended to be small if the number of the studies involved in the meta-analysis was large. The proposed estimators could be favorably applied in a meta-analysis on comparing two surgeries for asymptomatic congenital lung malformations in young children.