Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease

Background: Recently described neuronal intermediate filament inclusion disease (NIFID) shows considerable clinical heterogeneity. Objective: To assess the spectrum of the clinical and neuropathological features in 10 NIFID cases. Methods: Retrospective chart and comprehensive neuropathological review of these NIFID cases was conducted. Results: The mean age at onset was 40.8 (range 23 to 56) years, mean disease duration was 4.5 (range 2.7 to 13) years, and mean age at death was 45.3 (range 28 to 61) years. The most common presenting symptoms were behavioral and personality changes in 7 of 10 cases and, less often, memory loss, cognitive impairment, language deficits, and motor weakness. Extrapyramidal features were present in 8 of 10 patients. Language impairment, perseveration, executive dysfunction, hyperreflexia, and primitive reflexes were frequent signs, whereas a minority had buccofacial apraxia, supranuclear ophthalmoplegia, upper motor neuron disease (MND), and limb dystonia. Frontotemporal and caudate atrophy were common. Histologic changes were extensive in many cortical areas, deep gray matter, cerebellum, and spinal cord. The hallmark lesions of NIFID were unique neuronal IF inclusions detected most robustly by antibodies to neurofilament triplet proteins and α-internexin. Conclusion: NIFID is a neuropathologically distinct, clinically heterogeneous variant of frontotemporal dementia (FTD) that may include parkinsonism or MND. Neuronal IF inclusions are the neuropathological signatures of NIFID that distinguish it from all other FTD variants including FTD with MND and FTD tauopathies.
Cognitive Work Analysis: Foundations, Extensions, and Challenges

Abstract : This essay, which reviews the foundations, extensions, and challenges of cognitive work analysis, is based on a keynote address delivered at the 10th International Naturalistic Decision Making Conference held in Orlando, Florida from 31 May to 3 June, 2011. It describes the origins of cognitive work analysis and the utility of this framework for designing ecological interfaces, as well as for tackling a variety of other design challenges, particularly, the design of teams or organisations. Also featured in this essay is the formulation of a methodological perspective of cognitive work analysis, which complements the conceptual accounts provided by Rasmussen (1986), Rasmussen, Pejtersen, and Goodstein (1994), and Vicente (1999). Finally, this essay highlights the latest shift in research emphasis from work domain analysis, the first dimension of cognitive work analysis, to the subsequent dimensions of this framework.
Tax Policy in a Model of Search with Training

This paper develops a model of search on the labour market with training. The model reveals how the tax system can restore the social optimum if the Hosios condition is not satisfied in the private equilibrium. Furthermore, the effects are explored of a second-best reform from average to marginal taxes when a given amount of public revenue has to be raised. We find that (i) a marginal wage tax is less distortionary to raise revenue than is an average tax per job, provided that training is not distorted initially; (ii) this conclusion may reverse in the presence of training distortions; (iii) marginal wage taxes are less distortionary in economies characterized by commitment in wage bargaining, such as the European labour market. Hence, tax reforms that reduce the average tax per job and raise the marginal wage tax, such as an EITC or a negative income tax, are more attractive in Europe than in the US.
Achieving Guaranteed Anonymity in GPS Traces via Uncertainty-Aware Path Cloaking

The integration of Global Positioning System (GPS) receivers and sensors into mobile devices has enabled collaborative sensing applications, which monitor the dynamics of environments through opportunistic collection of data from many users' devices. One example that motivates this paper is a probe-vehicle-based automotive traffic monitoring system, which estimates traffic congestion from GPS velocity measurements reported from many drivers. This paper considers the problem of achieving guaranteed anonymity in a locational data set that includes location traces from many users, while maintaining high data accuracy. We consider two methods to reidentify anonymous location traces, target tracking, and home identification, and observe that known privacy algorithms cannot achieve high application accuracy requirements or fail to provide privacy guarantees for drivers in low-density areas. To overcome these challenges, we derive a novel time-to-confusion criterion to characterize privacy in a locational data set and propose a disclosure control algorithm (called uncertainty-aware path cloaking algorithm) that selectively reveals GPS samples to limit the maximum time-to-confusion for all vehicles. Through trace-driven simulations using real GPS traces from 312 vehicles, we demonstrate that this algorithm effectively limits tracking risks, in particular, by eliminating tracking outliers. It also achieves significant data accuracy improvements compared to known algorithms. We then present two enhancements to the algorithm. First, it also addresses the home identification risk by reducing location information revealed at the start and end of trips. Second, it also considers heading information reported by users in the tracking model. This version can thus protect users who are moving in dense areas but in a different direction from the majority.
Association of lichen planus with hepatitis C virus infection

BACKGROUND An association between HCV infection and lichen planus is uncertain because the prevalence of HCV infection in patients with lichen planus varies considerably from one geographic area to another. The purpose of this study was to determine the frequency of anti-HCV antibodies and its association with various clinical types of lichen planus in Mekkah, Saudi Arabia. METHODS A total of 114 cases of lichen planus were selected for the study. These were divided into four categories, including patients with skin lesions, skin and oral lesions, and oral or genital lesions alone. The sera of these patients were tested for HCV antibodies by means of a third-generation ELISA and serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were simultaneously determined. A group of 65 volunteers served as a control group. RESULTS Of the 114 patients with lichen planus, 30 had HCV antibodies (26.3%). In the 65 control group subjects anti-HCV antibodies were observed in 3 volunteers (4.6%). There was a significant difference between the two groups (P<0.0001). The ALT was raised in 22 patients and the AST level was elevated in 14 of the 114 cases of lichen planus. In the control group, the AST level was raised in 3 of the 65 controls while 2 had an elevated ALT level. The number of patients with an abnormal transaminase level also significantly differed in the two groups. CONCLUSION A high prevalence of HCV infection was detected in patients with lichen planus. These results support a possible relationship between lichen planus and hepatitis C.
Size of free neutral CO2 clusters from carbon 1s ionization energies.

Free neutral CO(2) clusters were produced by adiabatic expansion and characterized by carbon 1s (C1s) photoelectron spectroscopy using synchrotron radiation. The shift in C1s ionization energy (IE) between the cluster and the monomer, i.e., ΔIE = IE(cluster) - IE(monomer), was found to vary systematically with the experimental conditions. A functional relationship is established between the mean cluster size in the beam, , and ΔIE, in good agreement with theoretical calculations of shifts in ionization energy for model clusters. This makes it possible to use core-level photoelectron spectroscopy to monitor the mean cluster size and also to estimate from expansion conditions.
Changes in female sexual function following anterior with and without posterior vaginal mesh surgery for the treatment of pelvic organ prolapse.

INTRODUCTION Comparison of female sexual function following anterior and total transvaginal mesh (TVM) surgery has never been reported. AIM To compare the sexual function after anterior and total TVM repair for the treatment of pelvic organ prolapse (POP). MAIN OUTCOME MEASURES The short forms of Urogenital Distress Inventory (UDI-6) and Incontinence Impact Questionnaire (IIQ-7), and the Female Sexual Function Index (FSFI). METHODS One hundred and sixty-five women with symptomatic POP stages II to IV defined by the POP quantification (POP-Q) staging system underwent TVM procedures at our hospitals. Seventy women were included because they were sexually active and had complete follow-up. All subjects were divided into the anterior group (anterior TVM; N=39) and total group (anterior and posterior TVM; N=31). Preoperative and postoperative assessments included pelvic examination using the POP-Q system, urodynamic study, and a personal interview to evaluate urinary and sexual symptoms with the short forms of UDI-6 and IIQ-7, and the FSFI. RESULTS There was no difference between the two groups as for age, parity, diabetes, hypertension, concomitant procedures, and success rates for TVM and mid-urethral sling in this study (P>0.05). Regarding the POP-Q analysis, there was a significant improvement at points Aa, Ba, C, Ap, and Bp (P<0.05) in both groups except for total vaginal length (P>0.05). The preoperative scores of UDI-6 and IIQ-7 were significantly higher in the total group (P<0.01), and the UDI-6 and IIQ-7 scores showed significant decreases in both groups postoperatively (P<0.01). After TVM surgery, the score of the dyspareunia domain worsened significantly in both groups (P<0.05), and the deteriorated lubrication domain was noted only in the total group (P=0.042). CONCLUSIONS TVM procedure creates an effective anatomical restoration of POP, but individual domains of FSFI may worsen. Compared with the anterior group, women of the total group had worse quality of life in term of urinary symptoms preoperatively, and experienced a greater sexual impairment on lubrication following surgery.
Reconstruction of Massive Bone Defects with Allograft in Revision Total Knee Arthroplasty*

Allograft bone was used to reconstruct a defect in the proximal aspect of the tibia or the distal aspect of the femur, or both, in thirty knees of twenty-eight patients who had a revision total knee arthroplasty. The average age of the patients at the time of the index procedure was 65.8 years (range, twenty-four to eighty-nine years). At an average of fifty months (range, twenty-four to 132 months; median, thirty-six months) postoperatively, the score for twenty-three knees (twenty-one patients) had increased by at least 20 points, and these knees did not need additional operative treatment. Thus, the rate of success was 77 per cent. The procedure was considered a failure for the remaining seven knees because of infection (three), loosening of the tibial component (two), fracture of the graft (one), and non-union at the allograft-host junction (one). Properly applied allograft can be used to reconstruct massive bone defects, provide stability and support for implants, and restore bone stock in the event that additional operative treatment is necessary.
Electroweak baryon number non-conservation in the early Universe and in high-energy collisions

We review recent progress in the study of the anomalous baryon number non-conservation at high temperatures and in high-energy collisions. Recent results on high temperature phase transitions are described, and applications to the electroweak baryogenesis are considered. The current status of the problem of electroweak instanton-like processes at high energies is outlined.
Reliability of results and interpretation of measures of 3-methylhistidine in muscle interstitium as marker of muscle proteolysis.

TO THE EDITOR: We were interested in the contribution by Tesch and colleagues to the evidence base concerning the events subsequent to acute immobilization in human muscle. Tesch and colleagues (14) used a microdialysis technique applied to human muscle in an attempt to measure an index of myofibrillar proteolysis 72 h after immobilization using the unilateral leg suspension technique. The authors discuss their results as though they had good evidence that the technique they used produces results that are sufficiently firm to be the basis of conjecture about mechanisms of protein balance in muscle after immobilization. We demur and propose that they are on very shaky ground. First, we wonder about the size of the effect reported. The authors claim it to be 44%, but calculation of the change shows it to be actually 29% with the SEs sufficiently large that they almost span the difference; SDs must overlap. Significance at the 5% level can only barely have been reached. Are the authors convinced that they have not ignored a type I error? The authors (14) begin their explanation of the advantages of the dialysis technique using 3-methylhistidine (3MeHis) by describing the gold standard method, i.e., the stable isotopelabeled amino acid tracer dilution method, as cumbersome and possibly unjustified in study of otherwise healthy subjects. We find this notion strange since Ferrando and colleagues (6, 12) have used the technique in many studies of how immobilization affects muscle protein turnover subsequent to disuse. We have also used the techniques in a wide variety of studies of proteolysis in healthy and infirm subjects (1, 2, 10, 11, 15) with no problems and, we would propose, producing results with a greater degree of certainty and biological appropriateness than those obtained by the 3MeHis dialysis technique.
Relapse more common than reinfection in recurrent tuberculosis 1-2 years post treatment in urban Uganda.

OBJECTIVE To determine the proportion of recurrent tuberculosis (TB) due to relapse with the patient's initial strain or reinfection with a new strain of Mycobacterium tuberculosis 1-2 years after anti-tuberculosis treatment in Uganda, a sub-Saharan TB-endemic country. DESIGN Records of patients with culture-confirmed TB who completed treatment at an urban Ugandan clinic were reviewed. Restriction fragment length polymorphism (RFLP) patterns were used to determine relapse or reinfection. Associations between human immunodeficiency virus (HIV) positivity and type of TB recurrence were determined. RESULTS Of 1701 patients cured of their initial TB episode with a median follow-up of 1.24 years, 171 (10%) had TB recurrence (8.4 per 100 person-years). Rate and risk factors for recurrence were similar to other studies from sub-Saharan Africa. Insertion sequence (IS) 6110-based RFLP of paired isolates from 98 recurrences identified 80 relapses and 18 reinfections. Relapses among HIV-positive and -negative patients were respectively 79% and 85% of recurrences. CONCLUSIONS Relapse was more common and presented earlier than reinfection in both HIV-positive and -negative TB patients 1-2 years after completing treatment. These findings impact both the choice of retreatment drug regimen, as relapsing patients are at higher risk for acquired drug resistance, and clinical trials of new TB regimens with relapse as clinical endpoint.
Gait parameters in four strains of turkeys and correlations with bone strength.

Locomotion problems in meat poultry have multifactorial etiology. A better understanding of normal gait and its influences on biomechanical aspects of leg bones among turkey genetic lines is important to prevent skeletal disorders and locomotion issues. The objective of this experiment was to determine the possible differences in gait kinetic and kinematic parameters of turkey strains and their effects on bone biomechanical properties. Four genetic lines, named A, B, C, and D, were obtained and raised in 48 floor pens with new pine shavings. Leg health issues were classified at 16 and 33 d of age. Fifteen turkeys from each strain with apparent normal legs and gait at 33 d of age were selected for gait analysis. These 15 turkeys were trained to walk on a pressure sensitive walkway and video was recorded to calculate articulation movements. These data also were analyzed to obtain kinetic and kinematic parameters of the gait cycle collected at 47, 84, 107, and 145 d of age. At 20 wk all turkeys were sacrificed, and legs were collected and frozen for analysis. Weights and morphologic measurements of the femur, tibia, and shank were recorded. Bone mineral density (BMD) and content (BMC) were obtained using DEXA. Femur and tibia strength were evaluated by a 4-point bending test and torsion test, respectively. Gait parameters changed as toms aged and some differences were observed among lines. Genetic lines differed on BMD, but not on BMC. Strain D had a higher BMD and smaller diaphyseal angle than strain C, characteristics that were correlated with stronger bones. Strain D also had the lowest incidence of leg problems while strain C had the highest. Furthermore, the D strain had a smaller vertical motion of the toe than strains C and B at 47 d and strain A at 145 d, indicating that the D strain had a more efficient gait. In summary, genetic strains differ significantly on gait parameters, which in turn impacts bone biomechanics.
Gender differences in protein metabolism

Adult male and female humans have clear differences in muscle mass and there is mounting evidence that substrate metabolism differs between genders. These facts suggest that there are gender differences in protein metabolism between males and females. Studies utilizing stable isotopically labeled amino acids show little indication that whole body protein synthesis or breakdown is different between genders. There is evidence that leucine oxidation may be different, both at rest and during exercise, but this evidence is not unequivocal and more, properly controlled studies need to be undertaken to clarify this controversy. Muscle hypertrophy results from positive net muscle protein balance, thus, adult males must have greater net muscle protein synthesis than females, at least at some point in development. Although there is a paucity of data, no gender differences in the basal level net muscle protein balance have been found. It is possible that there are small differences that cannot be distinguished with current methods due to small sample sizes and the sensitivity of the methods. It is more likely, however, that sex hormones contribute to the clear differences in musculature by influencing muscle protein metabolism, especially during puberty. Testosterone increases muscle protein synthesis and net muscle protein balance, resulting in increased muscle mass. Males and females have similar amounts of testosterone until puberty, then testosterone levels increase much more dramatically in males, as does muscle mass. Furthermore, although no evidence exists in humans, in-vitro and rat data suggest that ovarian hormones inhibit muscle protein synthesis. Whereas solid conclusions are difficult to make given the paucity of studies focusing on gender differences in human protein metabolism, it seems that the sex hormones may play an important role. Certainly, more studies need to be conducted to ascertain what gender differences in whole body and muscle protein metabolism exist and how these differences result in different phylogenetic characteristics.
How does homework ‘work’ for young children? Children’s accounts of homework in their everyday lives

Homework is an increasing yet under-researched part of young children’s everyday lives. Framed by the international agendas of starting strong and school accountability, homework in the lives of young children has been either overlooked or considered from the perspective of adults rather than from the perspective of children themselves. This paper redresses this situation by reporting on an Australian study of 120 young children, aged four to eight years, where homework emerges as a key part of their everyday lives. Children’s own accounts of their everyday decision-making, using audio-taped conversations and concurrent paper-based timeline activities, show homework as accomplishing the institutional purposes of the school, while affording the children opportunities to demonstrate their competence in operating in an adult-generated education regime.
Does Functional Variation in Cognitive Control Systems of the Brain Link Reappraisal to the Metabolic Syndrome

Negative emotionality is associated with an increased risk for developing the metabolic syndrome (MetS). Presumably, negative emotionality partly confers such risk via alterations in peripheral autonomic and neuroendocrine effector pathways that promote metabolic pathophysiology. Conversely, protection against risk for the MetS may be conferred by an individual’s tendency to use cognitive strategies to regulate negative emotions. However, the brain systems by which cognitive emotion regulation relates to the MetS are unknown. Accordingly, we examined whether prefrontal and cingulate brain systems that jointly support cognitive emotion regulation and control peripheral physiological responses to negative emotional states represent a pathway linking emotion regulation to the MetS. Middle-aged adults (N=139; 74 men; mean age, 40.39 ± 6.2 years) underwent an fMRI scan while performing a Stroop color-word task that requires cognitive control, evokes a negative emotional state, and engages prefrontal and cingulate brain areas. Individual differences in self-reported tendencies to use cognitive reappraisal as an emotion regulation strategy were assessed by the Emotion Regulation Questionnaire (ERQ). The presence of the MetS was determined using the criteria of the National Cholesterol Education Program, Adult Treatment Panel III. After adjusting for age and sex, frequent cognitive reappraisal usage was associated with reduced likelihood of having the MetS and with meeting fewer MetS criteria. Moreover, fMRI psychophysiological interaction analyses revealed that increasing task-evoked functional connectivity between the dorsal anterior cingulate (dACC) and dorsolateral prefrontal cortex (DLPFC) was associated with frequent cognitive reappraisal usage, reduced presence of the MetS, and meeting less MetS criteria, net the influence of age and sex. In an exploratory mediation analysis, this positive dACC-DLPFC connectivity mediated the association between cognitive reappraisal and the MetS. Individuals who frequently use cognitive reappraisal may be at lesser MetS risk in part via an enhanced capacity to recruit prefrontal cognitive control systems during negative affective states.