Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiac rehabilitation in patients with acute coronary syndrome with primary percutaneous coronary intervention is associated with improved 10-year survival

Aims We aimed to assess the effects of a multidisciplinary cardiac rehabilitation (CR) program on survival after treatment with primary percutaneous coronary intervention (pPCI) for acute coronary syndrome (ACS). Methods and results Using propensity matching analysis, a total of 1159 patients undergoing CR were 1:1 matched with ACS patients who did not undergo CR and survived at least 60 days. The Kaplan-Meier analyses and multivariate Cox regression analysis were applied to study differences in survival. During follow-up, a total of 335 (14.5%) patients had died. Cumulative mortality rates at 5 and 10 years were 6.4% and 14.7% after CR and 10.4% and 23.5% in the no CR group (P < 0.001). Cardiac rehabilitation patients had 39% lower mortality than non-CR controls [10-year mortality 14.7% vs. 23.5%; adjusted hazard ratio (HR) 0.61; 95% confidence interval (CI) 0.46-0.81]. A total of 915 (78.9%) patients completed CR and had 46% lower mortality than those who did not complete CR (10-year mortality 13.6% vs. 18.9%; adjusted HR 0.54; 95% CI 0.42-0.70). Conclusion Patients who underwent pPCI for ACS, with a CR program had lower mortality than their non-CR counterparts. Mortality was particularly low in patients who completed the program. In conclusion, CR is still beneficial in terms of survival.
DPP-4 Inhibitors as Treatments for Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Objective Several clinical studies have reported the application of dipeptidyl peptidase-4 (DPP-4) inhibitors as treatments for type 1 diabetes mellitus (T1DM). This study aims to review the outcomes of these existing studies and to discuss the therapeutic effects of DPP-4 inhibitors on T1DM. Methods We thoroughly searched the Medline, Embase, PubMed, and Cochrane Library databases and ClinicalTrials.gov for studies concerning the use of DPP-4 inhibitors in patients with T1DM. Results In preclinical trials, DPP-4 inhibitors improved the pathogenesis of T1DM. However, only a portion of the studies showed potential efficacy regarding clinical glycemic control and other clinical parameters. From this meta-analysis, pooled data from 5 randomized controlled trials revealed that the additional use of DPP-4 inhibitors resulted in a greater decrease in glycated hemoglobin A1c (HbA1c) levels (0.07%, 95% CI (−0.37%–0.23%)) than insulin monotherapy, although the decrease was not significant. A small decrease in postprandial glucose or insulin consumption was confirmed. Conclusion Although DPP-4 inhibitors may be beneficial for T1DM, existing studies do not strongly support these positive effects in clinical practice. Further optimized clinical trials are needed.
Smartphone Ownership Among US Adult Cigarette Smokers: 2014 Health Information National Trends Survey (HINTS) Data

Background Despite increasing interest in smartphone apps as a platform for delivery of tobacco cessation interventions, no previous studies have evaluated the prevalence and characteristics of smokers who can access smartphone-delivered interventions. Objective To guide treatment development in this new platform and to evaluate disparities in access to smartphone-delivered interventions, we examined associations of smartphone ownership with demographics, tobacco use and thoughts about quitting, other health behaviors, physical and mental health, health care access, and Internet and technology utilization using a nationally representative sample of US adult smokers. Methods Data were from the National Cancer Institute’s 2014 Health Information National Trends Survey 4 (HINTS 4), Cycle 4. This mailed survey targeted noninstitutionalized individuals aged 18 years or older using two-stage stratified random sampling. For this analysis, we restricted the sample to current smokers with complete data on smartphone ownership (n=479). Results Nearly two-thirds (weighted percent=63.8%, 248/479) of smokers reported owning a smartphone. Those who were younger (P<.001), employed (P=.002), never married (P=.002), and had higher education (P=.002) and income (P<.001) had the highest rates of ownership. Smartphone owners did not differ from nonowners on frequency of smoking, recent quit attempts, or future plans to quit smoking, although they reported greater belief in the benefits of quitting (P=.04). Despite being equally likely to be overweight or obese, smartphone owners reported greater fruit and vegetable consumption (P=.03) and were more likely to report past-year efforts to increase exercise (P=.001) and to lose weight (P=.02). No differences in health care access and utilization were found. Smartphone owners reported better physical and mental health in several domains and higher access to and utilization of technology and the Internet, including for health reasons. Conclusions Smartphone ownership among smokers mirrors many trends in the general population, including the overall rate of ownership and the association with younger age and higher socioeconomic status. Apps for smoking cessation could potentially capitalize on smartphone owners’ efforts at multiple health behavior changes and interest in communicating with health care providers via technology. These data also highlight the importance of accessible treatment options for smokers without smartphones in order to reach smokers with the highest physical and mental health burden and prevent worsening of tobacco-related health disparities as interventions move to digital platforms.
An Internet-Based Patient-Provider Communication System: Randomized Controlled Trial

Background Internet-based interactive websites for patient communication (patient portals) may improve communication between patients and their clinics and physicians. Objective The aim of the study was to assess the impact of a patient portal on patients’ satisfaction with access to their clinic and clinical care. Another aim was to analyze the content and volume of email messages and telephone calls from patients to their clinic. Methods This was a randomized controlled trial with 606 patients from an academic internal medicine practice. The intervention “portal” group used a patient portal to send secure messages directly to their physicians and to request appointments, prescription refills, and referrals. The control group received usual care. We assessed patient satisfaction at the end of the 6-month trial period and compared the content of telephone and portal communications. Results Portal group patients reported improved communication with the clinic (portal: 77/174 [44%] “a little better” or “a lot better;” control: 18/146 [12%]; χ2 = 38.8, df = 1, P < .001) and higher satisfaction with overall care (portal: 103/174 [59%] “very good” or “excellent;” control: 78/162 [48%]; χ2 = 4.1, df = 1, P = .04). Portal group patients also reported higher satisfaction with each of the portal’s services. Physicians received 1 portal message per day for every 250 portal patients. Total telephone call volume was not affected. Patients were more likely to send informational and psychosocial messages by portal than by phone. Of all surveyed patients, 162/341 (48%) were willing to pay for online correspondence with their physician. Of those willing to pay, the median amount cited was US $2 per message. Conclusions Portal group patients demonstrated increased satisfaction with communication and overall care. Patients in the portal group particularly valued the portal’s convenience, reduced communication barriers, and direct physician responses. More online messages from patients contained informational and psychosocial content compared to telephone calls, which may enhance the patient-physician relationship.
Fine-grained power control for combined input-crosspoint queued switches

Reducing the power consumption of packet switches is becoming increasingly significant to future networks. However, previous research all focused on reducing power in crossbar-based switches, which is either complex or not effective, especially in some extreme cases. This paper proposes to leverage the dynamic voltage and frequency scaling (DVFS) technique in the buffered crossbar-based switches, which is more flexible and simple. The basic idea is to decrease the working frequencies of the crosspoint buffers while still preserving the maximum throughput and the satisfactory delay. Traffic estimators are used at the input and output ports to estimate the traffic arrival rates, based on which the power controller can adjust the working frequencies of the crosspoint buffers at a fine-grained level. Simulation results show that the scheme is effective.
Relevance of visual inspection strategy and knowledge about everyday objects for X-ray baggage screening

The screening of passenger bags at airports can be understood as a visual inspection task that consists of visual search and decision. Security officers (screeners) visually search for prohibited items in X-ray images and decide whether secondary search (e.g. using manual search or explosive trace detection) is needed. A screener's decision can be explained with signal detection theory and its measures (hit rate, false alarm rate, sensitivity and decision criterion). In this experiment tested whether a specifically instructed visual inspection strategy can influence the hit and false alarm rate. In addition, it was investigated whether knowledge about the visual appearance of harmless everyday objects in X-ray images is relevant for the detection of prohibited items. To this end, 31 screeners of an international airport conducted a simulated X-ray baggage screening task with two different instructions (normal vs. liberal decision) on how to conduct visual inspection: In the normal decision condition, screeners were instructed to visually inspect the X-ray images like they were used to from their job. In the liberal decision condition, screeners were instructed to visually analyze each object in the X-ray image and only decide that the bag was harmless if each object in the image could be recognized as harmless The screeners knew half of the prohibited items from computer-based training while the other half were novel prohibited items. In addition, knowledge about the visual appearance of everyday objects in X-ray images was measured. The results show that screeners were able to change their decision criterion depending on the instructed visual inspection strategy. Knowledge about harmless everyday objects was positively associated with detection performance and most notably correlated with the hit rate for novel threat items in the liberal decision condition. Implications for improving X-ray screening at airports using a risk-based and adaptive approach are discussed.
Changes in co-morbidity pattern in patients starting renal replacement therapy in Europe—data from the ERA-EDTA Registry

Background Patients starting renal replacement therapy (RRT) for end-stage renal disease often present with one or more co-morbidities. This study explored the prevalence of co-morbidities in patients who started RRT in Europe during the period from 2005 to 2014. Methods Using data from patients aged 20 years or older from all 11 national or regional registries providing co-morbidity data to the European Renal Association - European Dialysis and Transplant Association Registry, we examined the prevalence of the following co-morbidities: diabetes mellitus (DM) (primary renal disease and/or co-morbidity), ischaemic heart disease (IHD), congestive heart failure (CHF), peripheral vascular disease (PVD), cerebrovascular disease (CVD) and malignancy. Results Overall, 70% of 7578 patients who initiated RRT in 2014 presented with at least one co-morbidity: 39.0% presented with DM, 25.0% with IHD, 22.3% with CHF, 17.7% with PVD, 16.4% with malignancy and 15.5% with CVD. These percentages differed substantially between countries. Co-morbidities were more common in men than in women, in older patients than in younger patients, and in patients on haemodialysis at Day 91 when compared with patients on peritoneal dialysis. Between 2005 and 2014 the prevalence of DM and malignancy increased over time, whereas the prevalence of IHD and PVD declined. Conclusions More than two-thirds of patients initiating RRT in Europe have at least one co-morbidity. With the rising age at the start of RRT over the last decade, there have been changes in the co-morbidity pattern: the prevalence of cardiovascular co-morbidities decreased, while the prevalence of DM and malignancy increased.
Predicting semi-regular patterns in morphologically complex words

Abstract We expect generative models of language to correctly predict surface forms from underlying forms, but morphologically complex words, especially compounds, can exhibit idiosyncratic outputs, which require an extra lexical listing. This results in (a) a poorer Minimum Description Length of our model and (b) failure of a grammar to capture patterning among exceptions. To solve an instance of this problem, we examine pitch-accent patterns of 2-mora-2-mora Japanese Yamato (native) noun-noun compounds, hitherto considered semi-predictable but which show gradient tendencies among constituents to trigger a particular accent pattern. In the framework of Gradient Symbolic Computation (Smolensky, Paul & Matthew Goldrick. 2015. Gradient symbolic computation. LSA Summer Institute Workshop. Chicago.), a type of harmonic grammar which allows partially activated feature values and weighted constraints, such gradient patterns can be captured through the additive combination of coalescing features on each conjunct, which results in a pitch accent when the summed activations surpass a threshold determined by the grammar. The ability of this framework to completely predict these semi-regular patterns holds promise that it can also explain similar kinds of patterns in other languages.
Genetic profiling using plasma-derived cell-free DNA in therapy-naïve hepatocellular carcinoma patients: a pilot study

Background Hepatocellular carcinomas (HCCs) are not routinely biopsied, resulting in a lack of tumor materials for molecular profiling. Here we sought to determine whether plasma-derived cell-free DNA (cfDNA) captures the genetic alterations of HCC in patients who have not undergone systemic therapy. Patients and methods Frozen biopsies from the primary tumor and plasma were synchronously collected from 30 prospectively recruited, systemic treatment-naïve HCC patients. Deep sequencing of the DNA from the biopsies, plasma-derived cfDNA and matched germline was carried out using a panel targeting 46 coding and non-coding genes frequently altered in HCCs. Results In 26/30 patients, at least one somatic mutation was detected in biopsy and/or cfDNA. Somatic mutations in HCC-associated genes were present in the cfDNA of 63% (19/30) of the patients and could be detected 'de novo' without prior knowledge of the mutations present in the biopsy in 27% (8/30) of the patients. Mutational load and the variant allele fraction of the mutations detected in the cfDNA positively correlated with tumor size and Edmondson grade. Crucially, among the seven patients in whom the largest tumor was ≥5 cm or was associated with metastasis, at least one mutation was detected 'de novo' in the cfDNA of 86% (6/7) of the cases. In these patients, cfDNA and tumor DNA captured 87% (80/92) and 95% (87/92) of the mutations, suggesting that cfDNA and tumor DNA captured similar proportions of somatic mutations. Conclusion In patients with high disease burden, the use of cfDNA for genetic profiling when biopsy is unavailable may be feasible. Our results support further investigations into the clinical utility of cfDNA in a larger cohort of patients.
Evolution and architecture of a West Mediterranean Upper Pleistocene to Holocene coastal apron‐fan system

The Quaternary deposits of tectonically stable areas are a powerful tool to investigate high‐frequency climate variations (<10 ka) and to distinguish allogenic and autogenic factors controlling deposition. Therefore, an Upper Pleistocene–Holocene coastal apron‐fan system in north–western Sardinia (Porto Palmas, Italy) was studied to investigate the relations between climate changes, sea‐level fluctuations and sediment source‐supply that controlled its development. The sedimentary sequence records the strong influence of local (wet/dry) and worldwide (sea‐level) environmental variations in the sedimentation and preservation of the deposits. A multi‐disciplinary approach allowed subdivision of the succession into four major, unconformity‐bounded stratigraphic units: U1 U2, U3 and U4. Unit U1, tentatively dated to the warm and humid Marine Isotopic Stage (MIS) 5, consists of sandy, gravelly coastal/beach deposits developed during high sea‐level in low‐lying areas. Unit U2 consists of debris‐flow dominated fan‐deposits (ca 74 ka; MIS 4), preserved as partial fills of small valleys and coves. Unit U2 is mainly composed of reddish silty conglomerate to pebbly siltstones sourced from the Palaeozoic metamorphic inland hills (bedrock), superficially disintegrated during the preceding warm, vegetation‐rich MIS 5. The cold and semi‐arid climate strongly reduced vegetation cover along the valley flanks. Therefore, sediment gravity‐flow processes, possibly activated by rainstorms, led to deposition of debris‐flow dominated fans. Unit U3 consists of water‐flow dominated alluvial‐fan deposits (ca 47 to 23 ka; MIS 3), developed on a slightly inclined coastal plain. Unit U3 is composed of sandstone and sandy conglomerate fed from two main sediment sources: metamorphic inland bedrock and Quaternary bioclastic‐rich shelf‐derived sands. During this cold phase, sea‐level dropped sufficiently to expose bioclastic sands accumulated on the shelf. Frequent climate fluctuations favoured inland aeolian transport of sand during dry phases, followed by reworking of the aeolian bodies by flash floods during wet phases. Bedrock‐derived fragments mixed with water‐reworked, wind‐blown sands led to the development of water‐flow dominated fans. The Dansgaard–Oeschger events possibly associated with sand landward deflation and main fan formations are Dansgaard–Oeschger 13 (ca 47 ka), Dansgaard–Oeschger 8 (ca 39 ka) and Dansgaard–Oeschger 2 (ca 23 ka). No record of sedimentation during MIS 2 was observed. Finally, bioclastic‐rich aeolianites (Unit U4, ca 10 to 5 ka; MIS 1), preserved on a coastal slope, were developed during the Holocene transgression (ca 10 to 5 ka; MIS 1). The studied sequence shows strong similarities with those of other Mediterranean sites; it is, however, one of the few where the main MIS 4 and MIS 3 climatic fluctuations are registered in the sedimentary record.
Natural gene expression variation studies in yeast

The rise of sequence information across different yeast species and strains is driving an increasing number of studies in the emerging field of genomics to associate polymorphic variants, mRNA abundance and phenotypic differences between individuals. Here, we gathered evidence from recent studies covering several layers that define the genotype–phenotype gap, such as mRNA abundance, allele‐specific expression and translation efficiency to demonstrate how genetic variants co‐evolve and define an individual's genome. Moreover, we exposed several antecedents where inter‐ and intra‐specific studies led to opposite conclusions, probably owing to genetic divergence. Future studies in this area will benefit from the access to a massive array of well‐annotated genomes and new sequencing technologies, which will allow the fine breakdown of the complex layers that delineate the genotype–phenotype map. Copyright © 2016 John Wiley & Sons, Ltd.
Computer Administered Safety Planning for Individuals at Risk for Suicide: Development and Usability Testing

Background Safety planning is a brief intervention that has become an accepted practice in many clinical settings to help prevent suicide. Even though it is quick compared to other approaches, it frequently requires 20 min or more to complete, which can impede adoption. A self-administered, Web-based safety planning application could potentially reduce clinician time, help promote standardization and quality, and provide enhanced ability to share the created plan. Objective The aim of this study was to design, build, and test the usability of a Web-based, self-administered safety planning application. Methods We employed a user-centered software design strategy led by a multidisciplinary team. The application was tested for usability with a target sample of suicidal patients. Detailed observations, structured usability ratings, and Think Aloud procedures were used. Suicidal ideation intensity and perceived ability to cope were assessed pre-post engagement with the Web application. Results A total of 30 participants were enrolled. Usability ratings were generally strong, and all patients successfully built a safety plan. However, the completeness of the safety plan varied. The mean number of steps completed was 5.5 (SD 0.9) out of 6, with 90% (27/30) of participants completing at least 5 steps and 67% (20/30) completing all 6 steps. Some safety planning steps were viewed as inapplicable to some individuals. Some confusion in instructions led to modifications to improve understandability of each step. Ratings of suicide intensity after completion of the application were significantly lower than preratings, pre: mean 5.11 (SD 2.9) versus post: mean 4.46 (SD 3.0), t27=2.49, P=. 02. Ratings of ability to cope with suicidal thoughts after completion of the application were higher than preratings, with the difference approaching statistical significance, pre: mean 5.93 (SD 2.9), post: mean 6.64 (SD 2.4), t27=−2.03, P=. 05. Conclusions We have taken the first step toward identifying the components needed to maximize usability of a self-administered, Web-based safety planning application. Results support initial consideration of the application as an adjunct to clinical contact. This allows for the clinician or other personnel to provide clarification, when needed, to help the patient build the plan, and to help review and revise the draft.
Regional Impact of Population Aging on Changes in Individual Self-perceptions of Aging: Findings From the German Ageing Survey

Background and Objectives The importance of self-perceptions of aging (SPA) for health and longevity is well documented. Comparably little is known about factors that contribute to SPA. Besides individual factors, the context a person lives in may shape SPA. Research has so far focused on country-level differences in age stereotypes, indicating that rapid population aging accompanies more negative age stereotypes. The present study expands previous research by investigating the impact of district-specific population aging within one country on different facets of SPA. Research Design and Methods Based on a large representative survey in Germany, the study investigates changes in SPA as ongoing development as well as the SPA of physical loss over a 12-year period in adults aged 40+. The study uses several indicators of population aging (e.g., population development, average age, greying index), to identify four clusters differing in their pace of population aging. Based on three-level latent change models, these clusters were compared in their impact on changes in SPA. Results Compared to districts with an average rate of population aging, the study shows that persons living in regions with a fast population aging rate (C1) hold more negative SPA in both facets (ps = .01). Districts with slow population aging (C2) have significantly higher SPA ongoing development (p = .03). Discussion and Implications The study underlines the importance for regional differences in population aging on the development of SPA. In particular, societies should be aware that fast population aging may result in more negative SPA.