Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Laser Doppler Imaging on Time to Grafting Decisions in Pediatric Burns

Early definitive treatment of burns facilitates optimal results by reducing the risk of subsequent hypertrophic scarring. Laser Doppler imaging (LDI) has been shown to assist in predicting burn wound healing potential. This study sought to determine whether use of LDI in pediatric burn patients has led to earlier decision making for grafting. The study cohort were patients who underwent a skin grafting procedure for a burn wound at a single institution, a state referral center for all major pediatric burns, between June 2006 and December 2007. Patients were divided into two groups: those who underwent LDI scanning and those who were only assessed clinically. Time of burn injury to time of decision making for the grafting procedure was calculated in days. Forty-nine percent of 196 patients underwent LDI. The mean time from the date of injury to decision making for graft procedure was 8.9 days in those patients who had an LDI scan vs 11.6 days in the group assessed by clinical observation alone. This trend for earlier decision for grafting procedure in the LDI group was statistically significant (P = .01). There was no significant difference between those patients who were scanned and those only assessed clinically in relation to gender, age, mechanism of injury, percentage BSA burnt, and wound culture results. There was a significant reduction in time to grafting decision in the LDI group. This would potentially lead to reduced length of stay, reduced number of hospital visits, and streamlined care for the patient and their family.
Seismic Vibration Control Using Superelastic Shape Memory Alloys

Superelastic NiTi shape memory alloy (SMA) wires and bars are studied to determine their damping and recentering capability for applications in the structural control of buildings subjected to earthquake loadings. These studies improve the knowledge base in regard to the use of SMAs in seismic design and retrofit of structures. The results show that the damping properties of austenitic SMAs are generally low. However, the residual strain obtained after loading to 6% strain is typically <0.75%. In general, it is shown that large diameters bars perform as well as wire specimens used in non-civil-engineering applications. The results of a small-scale shake table test are then presented as a proof of concept study of a SMA cross-bracing system. These results are verified through analytical nonlinear time history analysis. Finally, a three-story steel frame implementing either a traditional steel buckling-allowed bracing system or a SMA bracing system is analyzed analytically to determine if there is an advantage to using a SMA bracing system. The results show that the SMA braces improve the response of the braced frames.
SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival

Progressive failure of insulin-producing β-cells is the central event leading to diabetes, but the signaling networks controlling β-cell fate remain poorly understood. Here we show that SRp55, a splicing factor regulated by the diabetes susceptibility gene GLIS3, has a major role in maintaining the function and survival of human β-cells. RNA sequencing analysis revealed that SRp55 regulates the splicing of genes involved in cell survival and death, insulin secretion, and c-Jun N-terminal kinase (JNK) signaling. In particular, SRp55-mediated splicing changes modulate the function of the proapoptotic proteins BIM and BAX, JNK signaling, and endoplasmic reticulum stress, explaining why SRp55 depletion triggers β-cell apoptosis. Furthermore, SRp55 depletion inhibits β-cell mitochondrial function, explaining the observed decrease in insulin release. These data unveil a novel layer of regulation of human β-cell function and survival, namely alternative splicing modulated by key splicing regulators such as SRp55, that may cross talk with candidate genes for diabetes.
Mimicry and Prosocial Behavior

Recent studies have shown that mimicry occurs unintentionally and even among strangers. In the present studies, we investigated the consequences of this automatic phenomenon in order to learn more about the adaptive function it serves. In three studies, we consistently found that mimicry increases pro-social behavior. Participants who had been mimicked were more helpful and generous toward other people than were non-mimicked participants. These beneficial consequences of mimicry were not restricted to behavior directed toward the mimicker, but included behavior directed toward people not directly involved in the mimicry situation. These results suggest that the effects of mimicry are not simply due to increased liking for the mimicker, but are due to increased prosocial orientation in general.
Carbon Emission Disclosure and the Cost of Capital: An Analysis of Malaysian Capital Market

The main purpose of this study is to examine the relationship between voluntary disclosure and cost of capital by exploring the impact of voluntary carbon emission disclosure (VCED) on the firm’s weighted-average cost of capital. A carbon disclosure index is used to evaluate the quality of carbon emission disclosure in 2013 and 2014 annual reports of 247 Malaysian public listed companies. By using content analysis, the result highlights a significant increase in the level and quality of carbon emission disclosure practice from 2013 to 2014. In addition, the finding from regression analysis indicates insignificant relationship between VCED quality and weighted-average cost of capital. Overall, our findings suggest that the carbon emission disclosure is still low, as such, the quality of VCED do not have an impact on firm’s cost of capital. The results of the study allow the government to measure progress toward achieving its target to reduce carbon emission and will add weight to the call by accounting regulation body such as Malaysian Accounting Standard Board for a specific standard on carbon reporting.
A Review of Compression Glove Modifications to Enhance Functional Grip: A Case Series

A common complaint among patients with burns is their inability to grasp items while wearing compression gloves. Recent technological innovations permit the addition of grip-enhancing material to garment fabric. The purpose of this case series was to describe the course of development of compression gloves with enhanced grip modifications. Five different types of grip modifications were made during a period of 18 months. Five subjects who were prescribed compression gloves tested each type of glove. The gloves were fabricated with grip-enhancing material on the palmar surface in five ways: 1) rectangular rubber tabs; 2) honeycomb pattern silicone; 3) wave-like pattern silicone; 4) line pattern silicone beads; 5) line pattern silicone beads embedded into the fabric. Each glove was evaluated on a three-point Likert scale (0 = poor, 1 = moderate, 2 = good) for grip-enhancing qualities and durability. All five subjects reported similar experiences with each glove type: 1) the rectangular rubber tabs demonstrated poor grip and moderate durability; 2) the honeycomb pattern provided good grip but poor durability; 3) the wave pattern had good grip and moderate durability; 4) the silicone beads adhered to the fabric had moderate grip but poor durability; 5) the silicone beads embedded into the fabric had moderate grip and good durability. The wave pattern provided the best gripping capability and silicone embedded into the fabric demonstrated the best durability. A wave-like pattern silicone material embedded into the fabric seems to provide the best combination of grip and durability to enhance activities of daily living performance.
Clinical characteristics and outcomes of patients admitted with presumed microbial keratitis to a tertiary medical center in Israel.

PURPOSES Microbial keratitis is commonly diagnosed worldwide, and continues to cause significant ocular morbidity, requiring prompt and appropriate treatment. The objective of this study is to describe the clinical characteristics and outcomes of patients with presumed microbial keratitis admitted to The Goldschleger Eye Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel. METHODS A cross-sectional study was conducted, in which the medical records of patients with presumed microbial keratitis admitted during a period of 3 years were reviewed. RESULTS Keratitis was diagnosed in 276 patients (51% males and 48.9% females). The mean age was 39.29 ± 22.30 years. The hospital length of stay ranged from 1 to 65 days (mean 5.69 ± 5.508). Fortified antibiotics were still used at discharge in 72% of the cases. Overall visual acuity improved significantly from the time of admission to the 1st-week follow up visit showing a p<0.001 on the Wilcoxon signed ranks test. Contact lens wearing was present in 36.1% of the patients, although there was no significant relation with severity of the presentation and visual outcome (p>0.05). The degree of hypopyon and cells in the anterior chamber was significantly related to the hospital length of stay (r Spearman=0.31; p<0.001 and r Spearman=0.21; p<.001, respectively) as well as to a worse visual outcome (r Spearman=0.32; p<0.01 and r Spearman=0.18; p=0.01, respectively). Of all patients, 2.3% required an urgent therapeutic penetrating keratoplasty, and 1% underwent evisceration. There was no enucleation. CONCLUSION Treating keratitis aggressively and assuring patient compliance is imperative for a good final visual outcome. Inpatient treatment may have a positive impact on this outcome.
An Integrative Review of the Concealed Connection: Nurse Educators' Critical Thinking.

BACKGROUND The role of nurse educators in the development of students' critical thinking has been overlooked despite the emphasized need for effective teaching methods. METHOD An integrative review was performed to examine both quantitative and qualitative research published from 2000 to 2015 related to nurse educators' critical thinking. RESULTS Many barriers and facilitators existing on individual, interpersonal, and contextual levels affected nurse educators' critical thinking. Various tools have been used to measure nurse educators' critical thinking. This review also highlighted the continued lack of a consensus definition of critical thinking and the limited presence of conceptual models to guide the use of critical thinking in nursing education. CONCLUSION Continued examination of nurse educators' critical thinking is needed, given the limited number of studies that have been completed. Much needs to be explored further, including conceptualizations of critical thinking and confirmation of emerging themes identified in this review. [J Nurs Educ. 2017;56(11):648-654. ].
Balancing cognitive diversity and mutual understanding in multidisciplinary teams

Background: Interprofessional health care teams are increasingly utilized in health care organizations. Although there is support for their capacity to solve complex problems, there is also evidence that such teams are not always successful. In an effort to understand the capacity of interprofessional teams to innovate successfully, we investigate the role of cognitive diversity to establish whether and how knowledge differences lead to innovation. Purposes: The aim of this study was to construct and investigate a model of team innovation predicted by cognitive diversity. In addition to investigating the direct impact of cognitive diversity in interprofessional health care teams, we develop a model incorporating mediated and moderated effects. In this study, we explore the role of debate as a mediating factor capable of explaining the impact of cognitive diversity on innovation. We further propose that the link between cognitive diversity and innovation through debate is contingent upon trans-specialist knowledge, knowledge shared by health care professionals, spanning specialist divides and enabling mutual understanding. Methodology: The hypotheses were investigated using a cross-sectional, correlational design. Survey data received from 75 interprofessional teams employed in an acute care setting, representing a 36% response rate, were used to investigate our model. Findings: Analysis supports a significant relationship between cognitive diversity and debate, which is stronger when teams rate highly for trans-specialist knowledge. Results also support a positive relationship between debate and innovation and our full moderated mediated pathway. Practice Implications: A range of strategies are indicated by our results to increase innovation in interprofessional teams. In particular, interventions such as interprofessional education and training, which have been shown to facilitate the development of shared language and meaning, are recommended by our findings.
Superresolution imaging of the local density of states in plasmon lattices

Periodic plasmonic nanostructures have been found promising in controlling photoluminescence directivity and efficiency for a wide variety of applications. Because of the inhomogeneous spatial distribution of the photonic resonances of periodic plasmonic nanostructures, their influence on emission is strongly dependent on the position of emitters relative to the nanostructures. Therefore, mapping the local dependence of directivity, efficiency, and emission rate enhancements is key to understanding and optimizing the devices. We introduce a method of mapping the local enhancement of spontaneous emission rates of emitters coupled to periodic nanostructures based on stochastic superresolution imaging. As an example, we show superresolved measurements of the local density of states (LDOS) at 605 nm induced by a hexagonal lattice of aluminum nanoantennas with a spatial resolution of 40 nm, defined by the size of the colloidal nanosources we use as randomly dispersed probes. We demonstrate that our method is superior to near-field mapping of emission rates. Comparison with electrodynamic simulations indicates that the variation of the decay rate of the emitters in the investigated sample is hardly influenced by the lattice modes and mainly governed by single-particle LDOS variations and nearest-neighbor interactions.
Costs of a Staff Communication Intervention to Reduce Dementia Behaviors in Nursing Home Care.

CONTEXT Persons with Alzheimer's disease and other dementias experience behavioral symptoms that frequently result in nursing home (NH) placement. Managing behavioral symptoms in the NH increases staff time required to complete care, and adds to staff stress and turnover, with estimated cost increases of 30%. The Changing Talk to Reduce Resistivenes to Dementia Care (CHAT) study found that an intervention that improved staff communication by reducing elderspeak led to reduced behavioral symptoms of dementia or resistiveness to care (RTC). OBJECTIVE This analysis evaluates the cost-effectiveness of the CHAT intervention to reduce elderspeak communication by staff and RTC behaviors of NH residents with dementia. DESIGN Costs to provide the intervention were determined in eleven NHs that participated in the CHAT study during 2011-2013 using process-based costing. Each NH provided data on staff wages for the quarter before and for two quarters after the CHAT intervention. An incremental cost-effectiveness analysis was completed. ANALYSIS An average cost per participant was calculated based on the number and type of staff attending the CHAT training, plus materials and interventionist time. Regression estimates from the parent study then were applied to determine costs per unit reduction in staff elderspeak communication and resident RTC. RESULTS A one percentage point reduction in elderspeak costs $6.75 per staff member with average baseline elderspeak usage. Assuming that each staff cares for 2 residents with RTC, a one percentage point reduction in RTC costs $4.31 per resident using average baseline RTC. CONCLUSIONS Costs to reduce elderspeak and RTC depend on baseline levels of elderspeak and RTC, as well as the number of staff participating in CHAT training and numbers of residents with dementia-related behaviors. Overall, the 3-session CHAT training program is a cost-effective intervention for reducing RTC behaviors in dementia care.
Machine learning \& artificial intelligence in the quantum domain

Quantum information technologies, and intelligent learning systems, are both emergent technologies that will likely have a transforming impact on our society. The respective underlying fields of research -- quantum information (QI) versus machine learning (ML) and artificial intelligence (AI) -- have their own specific challenges, which have hitherto been investigated largely independently. However, in a growing body of recent work, researchers have been probing the question to what extent these fields can learn and benefit from each other. QML explores the interaction between quantum computing and ML, investigating how results and techniques from one field can be used to solve the problems of the other. Recently, we have witnessed breakthroughs in both directions of influence. For instance, quantum computing is finding a vital application in providing speed-ups in ML, critical in our "big data" world. Conversely, ML already permeates cutting-edge technologies, and may become instrumental in advanced quantum technologies. Aside from quantum speed-up in data analysis, or classical ML optimization used in quantum experiments, quantum enhancements have also been demonstrated for interactive learning, highlighting the potential of quantum-enhanced learning agents. Finally, works exploring the use of AI for the very design of quantum experiments, and for performing parts of genuine research autonomously, have reported their first successes. Beyond the topics of mutual enhancement, researchers have also broached the fundamental issue of quantum generalizations of ML/AI concepts. This deals with questions of the very meaning of learning and intelligence in a world that is described by quantum mechanics. In this review, we describe the main ideas, recent developments, and progress in a broad spectrum of research investigating machine learning and artificial intelligence in the quantum domain.
Gradual-Time Solution Doping for the Fabrication of Longitudinally Varying Optical Fibres

Standard MCVD process and solution doping are commonly used for processing rare-earth doped optical fibers. Since the 1970s, this technique is mainly employed to fabricate homogeneous preforms in the longitudinal direction. A variant is proposed here, by using two doping solutions and by applying a gradual time doping. To demonstrate the validity of this approach, three preforms were prepared with longitudinal gradient of La, Ce, and Al. Preforms were characterized by refractive index profile measurements and concentrations in optical fibers were characterized by EPMA. These results will allow to perform rapid material development in optical-fiber domain. This process is also expected to offer a new way to prepare optical fibers with varying longitudinal characteristics.
Regulation of Cytokine Production by the Unfolded Protein Response; Implications for Infection and Autoimmunity

Protein folding in the endoplasmic reticulum (ER) is an essential cell function. To safeguard this process in the face of environmental threats and internal stressors, cells mount an evolutionarily conserved response known as the unfolded protein response (UPR). Invading pathogens induce cellular stress that impacts protein folding, thus the UPR is well situated to sense danger and contribute to immune responses. Cytokines (inflammatory cytokines and interferons) critically mediate host defense against pathogens, but when aberrantly produced, may also drive pathologic inflammation. The UPR influences cytokine production on multiple levels, from stimulation of pattern recognition receptors, to modulation of inflammatory signaling pathways, and the regulation of cytokine transcription factors. This review will focus on the mechanisms underlying cytokine regulation by the UPR, and the repercussions of this relationship for infection and autoimmune/autoinflammatory diseases. Interrogation of viral and bacterial infections has revealed increasing numbers of examples where pathogens induce or modulate the UPR and implicated UPR-modulated cytokines in host response. The flip side of this coin, the UPR/ER stress responses have been increasingly recognized in a variety of autoimmune and inflammatory diseases. Examples include monogenic disorders of ER function, diseases linked to misfolding protein (HLA-B27 and spondyloarthritis), diseases directly implicating UPR and autophagy genes (inflammatory bowel disease), and autoimmune diseases targeting highly secretory cells (e.g., diabetes). Given the burgeoning interest in pharmacologically targeting the UPR, greater discernment is needed regarding how the UPR regulates cytokine production during specific infections and autoimmune processes, and the relative place of this interaction in pathogenesis.
Galaxy Zoo: the effect of bar-driven fuelling on the presence of an active galactic nucleus in disc galaxies

We study the influence of the presence of a strong bar in disc galaxies which host an active galactic nucleus (AGN). Using data from the Sloan Digital Sky Survey and morphological classificationsfromtheGalaxyZoo2project,wecreateavolume-limitedsampleof19756disc galaxiesat0.01 <z< 0.05whichhavebeenvisuallyexaminedforthepresenceofabar. Within this sample, AGN host galaxies have a higher overall percentage of bars (51.8percent) than inactive galaxies exhibiting central star formation (37.1percent). This difference is primarily due to known effects: that the presence of both AGN and galactic bars is strongly correlated with both the stellar mass and integrated colour of the host galaxy. We control for this effect by examining the difference in AGN fraction between barred and unbarred galaxies in fixed bins of mass and colour. Once this effect is accounted for, there remains a small but statistically significant increase that represents 16percent of the average barred AGN fraction. Using the L[O III]/MBH ratio as a measure of AGN strength, we show that barred AGNs do not exhibit stronger accretion than unbarred AGNs at a fixed mass and colour. The data are consistent with a model in which bar-driven fuelling does contribute to the probability of an actively growing black hole, but in which other dynamical mechanisms must contribute to the direct AGN fuelling via smaller, non-axisymmetric perturbations.
Evolution of the clinical trial landscape in Asia Pacific

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress. com/permissions.php Open Access Journal of Clinical Trials 2014:6 75–84 Open Access Journal of Clinical Trials Dovepress