Miracle-dz/UniFAR-FTUs huggingface dataset:
Reliability of assessing the sensory perception of children with profound intellectual and multiple disabilities: a case study.

BACKGROUND This study describes preliminary stages of developing a checklist to enable practitioners to determine the behavioural responses of children with profound intellectual and multiple disabilities to sensory stimuli. Reliability of currently used checklists is low, with a focus on the child's sensory integration instead of perception. METHODS The inter-rater reliability of a checklist was determined, and adjustments were made to improve reliability. RESULTS Strikingly, the reliability decreased for all components after adjustment. The effect of a smaller item pool was ruled out. The effect of familiarity of teachers as raters was examined. CONCLUSIONS Results show that teachers who know a child well could interpret that child's behaviour more accurately than persons who were unfamiliar with the child. However, reliability of the checklist remains a problem.
New Spectral Classification Technique for X-Ray Sources: Quantile Analysis

We present a new technique, quantile analysis, to classify the spectral properties of X-ray sources with limited statistics. Quantile analysis is superior to conventional approaches, such as X-ray hardness ratio or X-ray color analysis, for studying relatively faint sources or investigating a certain phase or state of a source in detail, where poor statistics do not allow spectral fitting using a model. Instead of working with predetermined energy bands, we determine the energy values that divide the detected photons into predetermined fractions of the total counts, such as the median (50%), terciles (33% and 67%), and quartiles (25% and 75%). We use these quantiles as an indicator of the X-ray hardness or color of the source. We show that the median is an improved substitute for the conventional X-ray hardness ratio. The median and other quantiles form a phase space, similar to the conventional X-ray color-color diagrams. The quantile-based phase space is more evenly sensitive over various spectral shapes than the conventional color-color diagrams, and it is naturally arranged to properly represent the statistical similarity of various spectral shapes. We demonstrate the new technique in the 0.3-8 keV energy range using the Chandra ACIS-S detector response function and a typical aperture photometry involving background subtraction. The technique can be applied in any energy band, provided the energy distribution of photons can be obtained.
Developmental Cognitive Neuroscience Reflecting on the Mirror Neuron System in Autism: a Systematic Review of Current Theories

There is much interest in the claim that dysfunction of the mirror neuron system in individuals with autism spectrum condition causes difficulties in social interaction and communication. This paper systematically reviews all published studies using neuroscience methods (EEG/MEG/TMS/eyetracking/EMG/fMRI) to examine the integrity of the mirror system in autism. 25 suitable papers are reviewed. The review shows that current data are very mixed and that studies using weakly localised measures of the integrity of the mirror system are hard to interpret. The only well localised measure of mirror system function is fMRI. In fMRI studies, those using emotional stimuli have reported group differences, but studies using non-emotional hand action stimuli do not. Overall, there is little evidence for a global dysfunction of the mirror system in autism. Current data can be better understood under an alternative model in which social top-down response modulation is abnormal in autism. The implications of this model and future research directions are discussed.
Cambrian Hyolitha of Siberian, Baltican and Avalonian aspect in east Laurentian North America: taxonomy and palaeobiogeography

Malinky, J.M. & Geyer, G. , 6 March 2019. Cambrian Hyolitha of Siberian, Baltican and Avalonian aspect in east Laurentian North America: taxonomy and palaeobiogeography. Alcheringa 43, 171–203. ISSN 0311-5518. Newly identified hyoliths from early Cambrian ‘Small Shelly Fossil’ assemblages in New York State and Quebec extend the geographical ranges of hyolith taxa, otherwise known only from Baltica and Siberia, into eastern Laurentian North America, and in some cases, are accompanied by significant stratigraphical range extensions. The newly recognized taxa from this region include the hyolithids Hexitheca washingtonensis sp. nov., Aimitus sp. , A. sp. cf. A. communis, Anabaricornus sp. , Similotheca americana, Grantitheca glenisteri, and the orthothecids Decoritheca sp. , Contitheca sp. , two species of Holmitheca, and two hyolith species that can not be confidently assigned to an order at this time. Early Cambrian limestone clasts within the Lower Ordovician of Quebec have produced the hyolithids Similotheca americana and Nevadotheca princeps. The occurrences of Aimitus, Anabaricornus, and Holmitheca provide a palaeobiogeographical link with hyolith assemblages in Siberia, and Hexitheca to Baltica. Contitheca not only is known from these areas, but also has been found in west Laurentia, Morocco, Korea and Antarctica. A review of previously named species demonstrates that none of their type materials can be confidently referred to genus or species level because of poor preservation. John M. Malinky [jmalinky@sbcglobal.net], Department of Physical Science, San Diego City College, 1313 Park Boulevard, San Diego, CA 92101, USA; Gerd Geyer* [gerd.geyer@uni-wuerzburg.de], Institut für Geographie und Geologie, Bayerische Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg, Germany.
WriteClick: Do acute phase markers explain body temperature and brain temperature after ischemic stroke?

In the WriteClick Author Response “Do acute phase markers explain body temperature and brain temperature after ischemic stroke? ” by J.M. Wardlaw et al. (Neurology® 2013;80:778), there is an error in one of the author affiliations. It should read Bartosz Karaszewski, Gdansk. The authors regret the error.
Latent Attractors: A Model for Context-Dependent Place Representations in the Hippocampus

Cells throughout the rodent hippocampal system show place-specific patterns of firing called place fields, creating a coarse-coded representation of location. The dependencies of this place codeor cognitive mapon sensory cues have been investigated extensively, and several computational models have been developed to explain them. However, place representations also exhibit strong dependence on spatial and behavioral context, and identical sensory environments can produce very different place codes in different situations. Several recent studies have proposed models for the computational basis of this phenomenon, but it is still not completely understood. In this article, we present a very simple connectionist model for producing context-dependent place representations in the hippocampus. We propose that context dependence arises in the den-tate gyrus-hilus (DGH) system, which functions as a dynamic selector, disposing a small group of granule and pyramidal cells to fire in response to afferent stimulus while depressing the rest. It is hypothesized that the DGH system dynamics has latent attractors, which are unmasked by the afferent input and channel system activity into subpopulations of cells in the DG, CA3, and other hippocampal regions as observed experimentally. The proposed model shows that a minimally structured hippocampus-like system can robustly produce context-dependent place codes with realistic attributes.
Inferring gene networks from time series microarray data using dynamic Bayesian networks

Dynamic Bayesian networks (DBNs) are considered as a promising model for inferring gene networks from time series microarray data. DBNs have overtaken Bayesian networks (BNs) as DBNs can construct cyclic regulations using time delay information. In this paper, a general framework for DBN modelling is outlined. Both discrete and continuous DBN models are constructed systematically and criteria for learning network structures are introduced from a Bayesian statistical viewpoint. This paper reviews the applications of DBNs over the past years. Real data applications for Saccharomyces cerevisiae time series gene expression data are also shown.
Flexible FPGA design for FDTD using OpenCL

Compared to classical HDL designs, generating FPGA with high-level synthesis from an OpenCL specification promises easier exploration of different design alternatives and, through ready-to-use infrastructure and common abstractions for host and memory interfaces, easier portability between different FPGA families. In this work, we evaluate the extent of this promise. To this end, we present a parameterized FDTD implementation for photonic microcavity simulations. Our design can trade-off different forms of parallelism and works for two independent OpenCL-based FPGA design flows. Hence, we can target FPGAs from different vendors and different FPGA families. We describe how we used pre-processor macros to achieve this flexibility and to work around different shortcomings of the current tools. Choosing the right design configurations, we are able to present two extremely competitive solutions for very different FPGA targets, reaching up to 172 GFLOPS sustained performance. With the portability and flexibility demonstrated, code developers not only avoid vendor lock-in, but can even make best use of real trade-offs between different architectures.
Regulation of M3 Muscarinic Receptor Expression and Function by Transmembrane Protein 147

The M3 muscarinic acetylcholine receptor (M3R) regulates many fundamental physiological functions. To identify novel M3R-interacting proteins, we used a recently developed yeast two-hybrid screen (split ubiquitin method) to detect interactions among membrane proteins. This screen led to the identification of many novel M3R-associated proteins, including the putative membrane protein transmembrane protein 147 (Tmem147). The amino acid sequence of Tmem147 is highly conserved among mammals, but its physiological roles are unknown at present. We initially demonstrated that Tmem147 could be coimmunoprecipitated with M3Rs in cotransfected mammalian cells (COS-7 cells). Confocal imaging studies showed that Tmem147 was localized to endoplasmic reticulum (ER) membranes and that the Tmem147/M3R interaction occurred in the ER of cotransfected COS-7 cells, resulting in impaired trafficking of the M3R to the cell surface. To study the role of Tmem147 in modulating M3R function in a more physiologically relevant setting, we carried out studies with H508 human colon cancer cells that endogenously express M3Rs and Tmem147. Treatment of H508 cells with carbachol, a hydrolytically stable acetylcholine analog, promoted H508 cell proliferation and activation of the mitogenic kinase, p90RSK. Small interfering RNA-mediated knockdown of Tmem147 expression significantly augmented the stimulatory effects of carbachol on H508 cell proliferation and p90RSK activation. These effects were associated with an increase in the density of cell surface M3Rs. Our data clearly indicate that Tmem147 represents a potent negative regulator of M3R function, most likely by interacting with M3Rs in an intracellular compartment (ER). These findings may lead to new strategies aimed at modulating M3R activity for therapeutic purposes.
Task impact on the visual attention in subjective image quality assessment

Visual attention is a main feature of the Human Visual System (HVS). Knowing and using the mechanisms of the visual attention could help to the improvement of image quality assessment methods. But, which kind of saliency should be taken into account? A free-task visual selective attention or a quality oriented visual selective attention. We recorded and evaluated the discrepancy between these two types of oculomotor behavior. The results show the impact of the viewing task on visual strategy.
Points, Lines and Diamonds: A two-sorted Modal Logic for Projective Planes

We introduce a modal language for talking about projective planes. This language is two-sorted, containing formulas to be evaluated at points and at lines, respectively. The language has two diamonds whose intended accessibility relations are the two directions of the incidence relation between points and lines. We provide a sound and complete axiomatization for the formulas that are valid in the class of projective planes. We also show that it is decidable whether a given formula is satisfiable in a projective plane, and we characterize the computational complexity of this satisfaction problem. ∗Institute of Logic, Language and Information, University of Amsterdam, Plantage Muidergracht 24, 1018 TV Amsterdam, The Netherlands. yde@wins.uva. nl The research of the author has been made possible by a fellowship of the Royal Netherlands Academy of Arts and Sciences
Analysis of Cryptic, Systemic Botrytis Infections in Symptomless Hosts

Botrytis species are generally considered to be aggressive, necrotrophic plant pathogens. By contrast to this general perception, however, Botrytis species could frequently be isolated from the interior of multiple tissues in apparently healthy hosts of many species. Infection frequencies reached 50% of samples or more, but were commonly less, and cryptic infections were rare or absent in some plant species. Prevalence varied substantially from year to year and from tissue to tissue, but some host species routinely had high prevalence. The same genotype was found to occur throughout a host, representing mycelial spread. Botrytis cinerea and Botrytis pseudocinerea are the species that most commonly occur as cryptic infections, but phylogenetically distant isolates of Botrytis were also detected, one of which does not correspond to previously described species. Sporulation and visible damage occurred only when infected tissues were stressed, or became mature or senescent. There was no evidence of cryptic infection having a deleterious effect on growth of the host, and prevalence was probably greater in plants grown in high light conditions. Isolates from cryptic infections were often capable of causing disease (to varying extents) when spore suspensions were inoculated onto their own host as well as on distinct host species, arguing against co-adaptation between cryptic isolates and their hosts. These data collectively suggest that several Botrytis species, including the most notorious pathogenic species, exist frequently in cryptic form to an extent that has thus far largely been neglected, and do not need to cause disease on healthy hosts in order to complete their life-cycles.
Mechanism of Genomic Instability in Cells Infected with the High-Risk Human Papillomaviruses

In HPV–related cancers, the “high-risk” human papillomaviruses (HPVs) are frequently found integrated into the cellular genome. The integrated subgenomic HPV fragments express viral oncoproteins and carry an origin of DNA replication that is capable of initiating bidirectional DNA re-replication in the presence of HPV replication proteins E1 and E2, which ultimately leads to rearrangements within the locus of the integrated viral DNA. The current study indicates that the E1- and E2-dependent DNA replication from the integrated HPV origin follows the “onion skin”–type replication mode and generates a heterogeneous population of replication intermediates. These include linear, branched, open circular, and supercoiled plasmids, as identified by two-dimensional neutral-neutral gel-electrophoresis. We used immunofluorescence analysis to show that the DNA repair/recombination centers are assembled at the sites of the integrated HPV replication. These centers recruit viral and cellular replication proteins, the MRE complex, Ku70/80, ATM, Chk2, and, to some extent, ATRIP and Chk1 (S317). In addition, the synthesis of histone γH2AX, which is a hallmark of DNA double strand breaks, is induced, and Chk2 is activated by phosphorylation in the HPV–replicating cells. These changes suggest that the integrated HPV replication intermediates are processed by the activated cellular DNA repair/recombination machinery, which results in cross-chromosomal translocations as detected by metaphase FISH. We also confirmed that the replicating HPV episomes that expressed the physiological levels of viral replication proteins could induce genomic instability in the cells with integrated HPV. We conclude that the HPV replication origin within the host chromosome is one of the key factors that triggers the development of HPV–associated cancers. It could be used as a starting point for the “onion skin”–type of DNA replication whenever the HPV plasmid exists in the same cell, which endangers the host genomic integrity during the initial integration and after the de novo infection.
Harms and benefits of adoptive immunotherapy for postoperative hepatocellular carcinoma: an updated review

The harms and benefits of adoptive immunotherapy (AIT) for patients with postoperative hepatocellular carcinoma (HCC) are controversial among studies. This study aims to update the current evidence on efficacy and safety of AIT for patients with HCC who have received curative therapy. Electronic databases were systematically searched to identify randomized controlled trials (RCTs) and cohort studies evaluating adjuvant AIT for patients with HCC after curative therapies. Recurrence and mortality were compared between patients with or without adjuvant AIT. Eight RCTs and two cohort studies involving 2,120 patients met the eligibility criteria and were meta-analyzed. Adjuvant AIT was associated with significantly lower recurrence rate than curative therapies alone at 1 year [risk ratio (RR) 0.64, 95%CI 0.49-0.82], 3 years (RR 0.85, 95%CI 0.79-0.91) and 5 years (RR 0.90, 95%CI 0.85-0.95). Similarly, adjuvant AIT was associated with significantly lower mortality at 1 year (RR 0.64, 95%CI 0.52-0.79), 3 years (RR 0.73, 95%CI 0.65-0.81) and 5 years (RR 0.86, 95%CI 0.79-0.94). Short-term outcomes were confirmed in sensitivity analyses based on RCTs or choice of a fixed- or random-effect meta-analysis model. None of the included patients experienced grade 3 or 4 adverse events. Therefore, this update reinforces the evidence that adjuvant AIT after curative treatment for HCC lowers risk of recurrence and mortality.
Perceptions of Hospital Pharmacist's Role in Pakistan's Healthcare System: A Cross-Sectional Survey

Purpose: To investigate hospital pharmacists’ perception of their current clinical role in Pakistan’s healthcare system. Methods: This was a cross-sectional study in a population that consisted of hospital pharmacists in Islamabad, Faisalabad and Lahore which are three cities in Punjab State, Pakistan. A sample of 116 hospital pharmacists was selected from public and private hospitals in these three cities. Results: At least 42.2 % of the hospital pharmacists were involved in patient education pertaining to drugs. Although they were willing to take personal responsibility for resolving drug-related problems encountered, 84.5 % of them conveyed that their current role is more focused on pharmacy record keeping. Only 57.8% of the pharmacist indicated that they were involved in compiling and updating of their hospital’s drug formulary. Conclusion: The findings suggest that hospital pharmacists in Pakistan do have concerns about their present professional roles and face significant barriers with regards to increasing their involvement in clinical services. However, they need to be proactive in their collaboration with other healthcare professionals if the concept of pharmaceutical care is to take root in the healthcare system.
Optimal and efficient merging schedules for video-on-demand servers

The simplest video-on-demand (VOD) delivery policy is to allocate a new media delivery stream to each client request when it arrives. This policy has the desirable properties of “immediate service” (there is minimal latency between the client request and the start of playback, assuming that sufficient server bandwidth is available to start the new stream), of placing minimal demands on client capabilities (the client receive bandwidth required is the media playback rate, and no client local storage is required), and of being simple to implement. However, the policy is untenable because it requires server bandwidth that scales linearly with the number of clients that must be supported simultaneously, which is too expensive for many applications.
Prion protein and aging

The cellular prion protein (PrPC) has been widely investigated ever since its conformational isoform, the prion (or PrPSc), was identified as the etiological agent of prion disorders. The high homology shared by the PrPC-encoding gene among mammals, its high turnover rate and expression in every tissue strongly suggest that PrPC may possess key physiological functions. Therefore, defining PrPC roles, properties and fate in the physiology of mammalian cells would be fundamental to understand its pathological involvement in prion diseases. Since the incidence of these neurodegenerative disorders is enhanced in aging, understanding PrPC functions in this life phase may be of crucial importance. Indeed, a large body of evidence suggests that PrPC plays a neuroprotective and antioxidant role. Moreover, it has been suggested that PrPC is involved in Alzheimer disease, another neurodegenerative pathology that develops predominantly in the aging population. In prion diseases, PrPC function is likely lost upon protein aggregation occurring in the course of the disease. Additionally, the aging process may alter PrPC biochemical properties, thus influencing its propensity to convert into PrPSc. Both phenomena may contribute to the disease development and progression. In Alzheimer disease, PrPC has a controversial role because its presence seems to mediate β-amyloid toxicity, while its down-regulation correlates with neuronal death. The role of PrPC in aging has been investigated from different perspectives, often leading to contrasting results. The putative protein functions in aging have been studied in relation to memory, behavior and myelin maintenance. In aging mice, PrPC changes in subcellular localization and post-translational modifications have been explored in an attempt to relate them to different protein roles and propensity to convert into PrPSc. Here we provide an overview of the most relevant studies attempting to delineate PrPC functions and fate in aging.
DASH-N: Joint Hierarchical Domain Adaptation and Feature Learning

Complex visual data contain discriminative structures that are difficult to be fully captured by any single feature descriptor. While recent work on domain adaptation focuses on adapting a single hand-crafted feature, it is important to perform adaptation of a hierarchy of features to exploit the richness of visual data. We propose a novel framework for domain adaptation using a sparse and hierarchical network (DASH-N). Our method jointly learns a hierarchy of features together with transformations that rectify the mismatch between different domains. The building block of DASH-N is the latent sparse representation. It employs a dimensionality reduction step that can prevent the data dimension from increasing too fast as one traverses deeper into the hierarchy. The experimental results show that our method compares favorably with the competing state-of-the-art methods. In addition, it is shown that a multi-layer DASH-N performs better than a single-layer DASH-N.
Misallocation of Capital in a Model of Endogenous Financial Intermediation and Insurance

In this paper we analyze productivity and welfare losses from capital misallocation in a general equilibrium model of occupational choice and endogenous financial intermediation. We study the effects of borrowing and lending, insurance, and risk sharing on the optimal allocation of resources. We find that financial markets together with general equilibrium effects have large impact on entrepreneurs’ entry and firm-size decisions. Efficiency gains are increasing in the quality of financial markets, particularly in their ability to alleviate a financing constraint by providing insurance against idiosyncratic risk.