Miracle-dz/UniFAR-FTUs huggingface dataset:
Forecasting Output and Inflation: The Role of Asset Prices

This paper examines old and new evidence on the predictive performance of asset prices for inflation and real output growth. We first review the large literature on this topic, focusing on the past dozen years. We then undertake an empirical analysis of quarterly data on up to 38 candidate indicators (mainly asset prices) for seven OECD countries for a span of up to 41 years (1959 1999). The conclusions from the literature review and the empirical analysis are the same. Some asset prices predict either inflation or output growth in some countries in some periods. Which series predicts what, when and where is, however, itself difficult to predict: good forecasting performance by an indicator in one period seems to be unrelated to whether it is a useful predictor in a later period. Intriguingly, forecasts produced by combining these unstable individual forecasts appear to improve reliably upon univariate benchmarks.
Rhodobacter sphaeroides Extract Lycogen™ Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats

Benign prostate hyperplasia (BPH) is one of the most common urological problems in mid-aged to elderly men. Risk factors of BPH include family history, obesity, type 2 diabetes, and high oxidative stress. The main medication classes for BPH management are alpha blockers and 5α-reductase inhibitors. However, these conventional medicines cause adverse effects. Lycogen™, extracted from Rhodobacter sphaeroides WL-APD911, is an anti-oxidant and anti-inflammatory compound. In this study, the effect of Lycogen™ was evaluated in rats with testosterone-induced benign prostate hyperplasia (BPH). Testosterone injections and Lycogen™ administration were carried out for 28 days, and body weights were recorded twice per week. The testosterone injection successfully induced a prostate enlargement. BPH-induced rats treated with different doses of Lycogen™ exhibited a significantly decreased prostate index (PI). Moreover, the Lycogen™ administration recovered the histological abnormalities observed in the prostate of BPH rats. In conclusion, these findings support a dose-dependent preventing effect of Lycogen™ on testosterone-induced BPH in rats and suggest that Lycogen™ may be favorable to the prevention and management of benign prostate hyperplasia.
Does the type of GnRH analogue used, affect live birth rates in women with endometriosis undergoing IVF/ICSI treatment, according to the rAFS stage?

Abstract Since the introduction of gonadotropin-releasing hormone (GnRH) antagonists, an extensive amount of literature investigating the role of the downregulation protocols on pregnancy outcomes has been published. However, these studies were mainly performed in the general infertile population where patients with endometriosis were often excluded or underrepresented. This study is a large retrospective cohort study including 386 endometriosis patients undergoing IVF/ICSI, who had been previously classified according to the rAFS system. Patients were stimulated either a long GnRH agonist or GnRH antagonist protocol. Depending on endometriosis stage, patients were divided into two groups: endometriosis stage I–II and endometriosis stage III–IV. Each group was subdivided, based on the type GnRH analog used. When comparing the GnRH agonist and antagonist groups, patients with endometriosis stage I–II, had a tendency toward higher β-hCG positive, clinical pregnancy, and live birth rates (42.8% vs. 26.7%; p = .07) in favor of GnRH agonist use. In endometriosis stage III–IV, no differences were observed between agonist and antagonist cycle in any of the pregnancy outcomes. Multivariate regression analysis did not reveal any significant predictor of live birth after adjusting for relevant confounders. Based on our findings, the chance to have a liveborn in endometriosis population seems not to be affected by the type of GnRH analog used, at least in advanced stages. Findings from stage I–II endometriosis cases merit consideration and further evaluation in a larger sample size is warranted.
A Cascading Failure Model for Command and Control Networks with Hierarchy Structure

Cascading failures in the command and control networks (C2 networks) could substantially affect the network invulnerability to some extent. In particular, without considering the characteristics of hierarchy structure, it is quite misleading to employ the existing cascading failure models and effectively analyze the invulnerability of C2 networks. Therefore, a novel cascading failure model for command and control networks with hierarchy structure is proposed in this paper. Firstly, a method of defining the node’s initial load in C2 networks based on hierarchy-degree is proposed. By applying the method, the impact of organizational positions and the degree of the node on its initial load could be highlighted. Secondly, a nonuniform adjustable load redistribution strategy (NALR strategy) is put forward in this paper. More specifically, adjusting the redistribution coefficient could allocate the load from failure nodes to the higher and the same level neighboring nodes according to different proportions. It could be demonstrated by simulation results that the robustness of C2 networks against cascading failures could be dramatically improved by adjusting the initial load adjustment coefficient, the tolerance parameter, and the load redistribution coefficient. And finally, comparisons with other relational models are provided to verify the rationality and effectiveness of the model proposed in this paper. Subsequently, the invulnerability of C2 networks could be enhanced.
Susceptibility to Invasive Meningococcal Disease: Polymorphism of Complement System Genes and Neisseria meningitidis Factor H Binding Protein

Background Neisseria meningitidis can cause severe infection in humans. Polymorphism of Complement Factor H (CFH) is associated with altered risk of invasive meningococcal disease (IMD). We aimed to find whether polymorphism of other complement genes altered risk and whether variation of N. meningitidis factor H binding protein (fHBP) affected the risk association. Methods We undertook a case-control study with 309 European cases and 5,200 1958 Birth Cohort and National Blood Service cohort controls. We used additive model logistic regression, accepting P<0.05 as significant after correction for multiple testing. The effects of fHBP subfamily on the age at infection and severity of disease was tested using the independent samples median test and Student’s T test. The effect of CFH polymorphism on the N. meningitidis fHBP subfamily was investigated by logistic regression and Chi squared test. Results Rs12085435 A in C8B was associated with odds ratio (OR) of IMD (0.35 [95% CI 0.19–0.67]; P = 0.03 after correction). A CFH haplotype tagged by rs3753396 G was associated with IMD (OR 0.56 [95% CI 0.42–0.76], P = 1.6x10−4). There was no bacterial load (CtrA cycle threshold) difference associated with carriage of this haplotype. Host CFH haplotype and meningococcal fHBP subfamily were not associated. Individuals infected with meningococci expressing subfamily A fHBP were younger than those with subfamily B fHBP meningococci (median 1 vs 2 years; P = 0.025). Discussion The protective CFH haplotype alters odds of IMD without affecting bacterial load for affected heterozygotes. CFH haplotype did not affect the likelihood of infecting meningococci having either fHBP subfamily. The association between C8B rs12085435 and IMD requires independent replication. The CFH association is of interest because it is independent of known functional polymorphisms in CFH. As fHBP-containing vaccines are now in use, relationships between CFH polymorphism and vaccine effectiveness and side-effects may become important.
SSM/I Rain Retrievals within a Unified All-Weather Ocean Algorithm

Abstract A new method for the physical retrieval of rain rates from satellite microwave radiometers is presented. The method is part of a unified ocean parameter retrieval algorithm that is based on the fundamental principles of radiative transfer. The algorithm simultaneously finds near-surface wind speed W, columnar water vapor V, columnar cloud liquid water L, rain rate R, and effective radiating temperature TU for the upwelling radiation. Comparisons with radiosondes demonstrate that the algorithm is able to retrieve water vapor when rain is present. For rain rates from 1 to 15 mm h−1, the rms difference between the retrieved water vapor and the radiosonde value is 5 mm. A novel feature of the rain retrieval method is a beamfilling correction that is based upon the ratio of the retrieved liquid water absorption coefficients at 37 and 19 GHz. This spectral ratio decreases by about 40% when heavy and light rain coexist within the SSM/I footprint as compared to the case of uniform rain. This correction i.
Modeling Wildfire-Induced Permafrost Deformation in an Alaskan Boreal Forest Using InSAR Observations

The discontinuous permafrost zone is one of the world’s most sensitive areas to climate change. Alaskan boreal forest is underlain by discontinuous permafrost, and wildfires are one of the most influential agents negatively impacting the condition of permafrost in the arctic region. Using interferometric synthetic aperture radar (InSAR) of Advanced Land Observation Satellite (ALOS) Phased Array type L-band Synthetic Aperture Radar (PALSAR) images, we mapped extensive permafrost degradation over interior Alaskan boreal forest in Yukon Flats, induced by the 2009 Big Creek wildfire. Our analyses showed that fire-induced permafrost degradation in the second post-fire thawing season contributed up to 20 cm of ground surface subsidence. We generated post-fire deformation time series and introduced a model that exploited the deformation time series to estimate fire-induced permafrost degradation and changes in active layer thickness. The model showed a wildfire-induced increase of up to 80 cm in active layer thickness in the second post-fire year due to pore-ice permafrost thawing. The model also showed up to 15 cm of permafrost degradation due to excess-ice thawing with little or no increase in active layer thickness. The uncertainties of the estimated change in active layer thickness and the thickness of thawed excess ice permafrost are 27.77 and 1.50 cm, respectively. Our results demonstrate that InSAR-derived deformation measurements along with physics models are capable of quantifying fire-induced permafrost degradation in Alaskan boreal forests underlain by discontinuous permafrost. Our results also have illustrated that fire-induced increase of active layer thickness and excess ice thawing contributed to ground surface subsidence.
Feature-based face representations and image reconstruction from behavioral and neural data

Significance The present work establishes a novel approach to the study of visual representations. This approach allows us to estimate the structure of human face space as encoded by high-level visual cortex, to extract image-based facial features from this structure, and to use such features for the purpose of facial image reconstruction. The derivation of visual features from empirical data provides an important step in elucidating the nature and the specific content of face representations. Further, the integrative character of this work sheds new light on the existing concept of face space by rendering it instrumental in image reconstruction. Last, the robustness and generality of our reconstruction approach is established by its ability to handle both neuroimaging and psychophysical data. The reconstruction of images from neural data can provide a unique window into the content of human perceptual representations. Although recent efforts have established the viability of this enterprise using functional magnetic resonance imaging (MRI) patterns, these efforts have relied on a variety of prespecified image features. Here, we take on the twofold task of deriving features directly from empirical data and of using these features for facial image reconstruction. First, we use a method akin to reverse correlation to derive visual features from functional MRI patterns elicited by a large set of homogeneous face exemplars. Then, we combine these features to reconstruct novel face images from the corresponding neural patterns. This approach allows us to estimate collections of features associated with different cortical areas as well as to successfully match image reconstructions to corresponding face exemplars. Furthermore, we establish the robustness and the utility of this approach by reconstructing images from patterns of behavioral data. From a theoretical perspective, the current results provide key insights into the nature of high-level visual representations, and from a practical perspective, these findings make possible a broad range of image-reconstruction applications via a straightforward methodological approach.
Serum cortisol level and survival rate of juvenile Epinephelus fuscoguttatus following exposure to different salinities

Background and Aim: Brown-marbled grouper Epinephelus fuscoguttatus is a premium marine food fish with high demand in Asia. In fish, stress due to environmental changes such as fluctuations in the salinity can result in increased cortisol level. Stress in fish increases susceptibility to diseases ultimately resulting in death. Therefore, the aim of this study was to investigate the salinity tolerance of E. fuscoguttatus and their survival in lower salinities. Materials and Methods: In this study, grouper juveniles (92.43±standard error of the mean 0.51 mm) maintained in 31 ppt seawater were transferred into five tanks with seawater diluted to 25, 20, 15, 10, and 5 ppt. The salinity of the control group was not changed and was maintained at 31 ppt. Serum cortisol was measured using ELISA at 0, 30, 60, and 120 min after the fish were transferred to the different concentrations of salinity. Results: The survival percentage was recorded for 14 days following the transfer and the results revealed that serum cortisol of fish in a high change in salinity (15, 10, and 5 ppt) was significantly higher than the control group immediately after exposure. At the high salinity change, the cortisol levels gradually decrease at 30 min and 60 min, until no difference in cortisol concentration was observed at 120 min. No mortality was observed in fish exposed to low salinity change (25 and 20 ppt) while in higher salinity change (5 ppt), the survival percentage was 50%. Conclusion: The study revealed that the serum cortisol concentration was high initially and continues to decrease to resting cortisol level at 120 min indicating that cortisol hormone is released following acute stress as a primary response in grouper juveniles.
Relationship between Gingival Crevicular Fluid Microbiota and Cytokine Profile in Periodontal Host Homeostasis

As potential biomarkers in periodontitis, microbiome, and cytokines have recently been extensively investigated, but combined analyses of the variations between the microbial structure and cytokine composition are rare. The present study aimed to investigate whether there are differences in the combined profile of microbiome and cytokines in individuals with or without periodontitis. The microbiome and cytokine composition in gingival crevicular fluid (GCF) from 16 patients and 15 controls from Jishi Shan (Gansu, China) were analyzed using 454 pyrosequencing and RayBio Quantibody Arrays. The results showed that a higher co-occurrence of genera in periodontitis group compared with the healthy group, as evaluated by Schoener's abundance-based co-occurrence index. C-reactive protein (CRP) was significantly (P < 0.05) higher in the GCF of the periodontitis group while interleukin (IL)-8 was significantly (P < 0.01) higher in the GCF of the healthy group. The Mantel test revealed a significant concordance between cytokines and microbiota, in the healthy group (Mantel statistic r = 0.36, P ≤ 0.05) but not in the periodontitis group (Mantel statistic r = 0.013, P = 0.434). The results were further confirmed by the Procrustes test. Matrix metalloproteinase (MMP)-9, osteoactivin, IL-8, and macrophage inflammatory protein (MIP)-1a were significantly associated with bacterial composition at the phylum, class, order, family, and genus levels. CRP was also associated with bacterial composition at the species level. In conclusion, alterations in the polymicrobial community structure leads to disruption in the healthy correlation between cytokines and microbiomes. This dysbiosis between the microbiota and the immune response could be one of the major etiological mechanisms underlying periodontitis.
Prevalence and clinical predictors of LPR among patients diagnosed with GERD according to the reflux symptom index questionnaire

Background/Aims: Gastroesophageal reflux disease (GERD) is a common condition that can lead to significant morbidity. Laryngopharyngeal reflux (LPR) is a distinct clinical entity that can occur simultaneously with GERD, necessitating additional treatment measures. The degree of overlap and clinical predictors of LPR among patients with GERD remains unknown. We aim to measure the prevalence of LPR in patients with GERD and identify clinical predictors. Patients and Methods: We performed a cross-sectional study involving patients with confirmed GERD according to the GERD questionnaire (GerdQ) using the reflux symptom index (RSI). Data on demographics, comorbidities, past and current medications, and GERD-related lifestyle measures were documented. The prevalence of LPR was calculated. Linear and logistic regression analyses were conducted to correlate GerdQ and RSI, and to identify clinical predictors of LPR, respectively. Results: A total of 80 patients with confirmed GERD were consecutively recruited and surveyed. Mean age was 43 (±16) and 60% were females. The majority of patients were Saudis (51%) and only 24% were smokers. The mean duration of GERD was 7 (±4.4) years and the average body mass index (BMI) was 36 ± 22. Sixty-six percent of the patients consumed coffee on regular basis. On simple and multiple linear regression analyses, a strong, positive correlation was observed between the GerdQ and RSI scores (coefficient = 1.13, 95%CI = 0.39–1.86), and ipratropium bromide inhaler was positively associated with RSI scores (coefficient = 13.12, 95%CI = 0.16–26.09). LPR was identified in 57 patients (71%). On simple and multiple logistic regression analyses, GerdQ scores (OR = 1.78, 95%CI = 1.13–2.80), BMI (OR = 1.07, 95%CI = 1.01–1.14), duration of GERD in years (OR = 1.42, 95%CI = 1.04–1.93), and the type of gender (OR = 49.67, 95%CI = 1.32–1870) appeared to increase the risk of LPR, whereas coffee consumption (OR = 0.0005, 95%CI = 1.82e–06, 0.13) appeared to be negatively associated with LPR. Conclusions: Contradictory to what is frequently reported, LPR commonly occurs and positively correlates with GERD. Several modifiable clinical predictors of LPR might exist, which highlight the importance of performing a complete clinical assessment of the patients with reflux symptoms.
HSOA Journal of Alcoholism, Drug Abuse and Substance Dependence Short

The importance of providing a controlled environment for research studies involving animals has long been understood. Housing and facility conditions are regulated to promote animal health and wel-fare, and reduce variability in experimental data. When performing behavioral studies on substance use, it has previously been shown that vibration or loud noise can serve as environmental stressors and alter drug intake. In a recent study by our laboratory, we observed that methamphetamine self-administration in young adult male rats was increased in the presence of intermittent vibration caused by heavy construction nearby but external to the research facility. More specifically, drug intake was significantly reduced on the initial day of exposure to the vibration, but was elevated over subsequent days such that at the end of the study, vibration-exposed rats had self-administered more drug than rats who were maintained under stable conditions. These findings further illustrate the effects that environmental disruption can have on experimental results, and particularly indicate that vibrations originating from sources outside of the research facility can still significantly impact experimental out - comes.
Coordinated multi-wavelength observations of Sgr A*

We report on recent near-infrared (NIR) and X-ray observations of Sagittarius A* (Sgr A*), the electromagnetic manifestation of the ∼4x106M⊙ super-massive black hole (SMBH) at the Galactic Center. The goal of these coordinated multi-wavelength observations is to investigate the variable emission from Sgr A* in order to obtain a better understanding of the underlying physical processes in the accretion flow/outflow. The observations have been carried out using the NACO adaptive optics (AO) instrument at the European Southern Observatory's Very Large Telescope (July 2005, May 2007) and the ACIS-I instrument aboard the Chandra X-ray Observatory (July 2005). We report on a polarized NIR flare synchronous to a 8x1033 erg/s X-ray flare in July 2005, and a further flare in May 2007 that shows the highest sub-flare to flare contrast observed until now. The observations can be interpreted in the framework of a model involving a temporary disk with a short jet. In the disk component flux density variations can be explained due to hot spots on relativistic orbits around the central SMBH. The variations of the sub-structures of the May 2007 flare are interpreted as a variation of the hot spot structure due to differential rotation within the disk.
Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach

The purpose of the present work was to determine the mechanisms by which microemulsions (MEs) enhance the oral bioavailability of puerarin. The in situ perfusion method was used in rats to study the absorption mechanisms of an oil-in-water (O/W) microemulsion (O/W-ME) and a water-in-oil (W/O) microemulsion (W/O-ME). The possibility of lymphatic transport of the MEs was investigated using a chylomicron flow blocking approach. The results for the absorption mechanisms in the stomach and intestines indicated that the absorption characteristics of the O/W-ME and W/O-ME depend on the segment. The W/O-ME had higher internal membrane permeability than the O/W-ME. The results of the lymphatic transport analyses showed that both the O/W-ME and W/O-ME underwent lymphatic transport and that this pathway was a major contributor to the oral bioavailability of MEs. Furthermore, the type of ME can significantly affect the absorption of puerarin through the lymphatic system due to the oil content and the form of the microemulsion after oral administration. In conclusion, these data indicate that microemulsions are an effective and promising delivery system to enhance the oral bioavailability of poorly water-soluble drugs.