Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans

1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), which is the biologically active form of vitamin D, has anti-inflammatory effects and can prevent experimental Parkinson's disease (PD). 1,25(OH)2D3 exerts most of its actions only after it binds to its specific nuclear receptors. Eighty-five Korean patients with PD and 231 unrelated healthy individuals were evaluated to determine if vitamin D receptor gene (VDRG) BsmI polymorphisms were markers for the susceptibility to PD in Korean patients. Each polymorphism was detected using polymerase chain reaction (PCR)-based restriction analysis. In addition, the relationship between the BsmI polymorphisms and the clinical manifestations of PD was evaluated. Overexpression of the b allele (91.2 vs. 85.7%; p=0.069) and homozygote bb (84.7 vs. 72.7%; p=0.043) was found in the PD patients compared with the controls. These results show for the first time an association between PD and a VDRG polymorphism, which might be involved in the pathogenesis of PD, or in the linkage disequilibrium of the VDRG to another pathogenic gene locus.
Broadcasting with Side Information

A sender holds a word x consisting of n blocks xi, each of t bits, and wishes to broadcast a codeword to m receivers, R1,. ,Rm. Each receiver Ri is interested in one block, and has prior side information consisting of some subset of the other blocks. Let betat be the minimum number of bits that has to be transmitted when each block is of length t, and let beta be the limit beta=limtrarrinfinbetat/t. Informally, beta is the average communication cost per bit in each block (for long blocks). Finding the coding rate beta, for such an informed broadcast setting, generalizes several coding theoretic parameters related to Informed Source Coding on Demand, Index Coding and Network Coding. In this work we show that usage of large data blocks may strictly improve upon the trivial encoding which treats each bit in the block independently. To this end, we provide general bounds on betat, and prove that for any constant C there is an explicit broadcast setting in which beta = 2 but beta1> C. One of these examples answers a question of . In addition, we provide examples with the following counterintuitive direct-sum phenomena. Consider a union of several mutually independent broadcast settings. The optimal code for the combined setting may yield a significant saving in communication over concatenating optimal encodings for the individual settings. This result also provides new non-linear coding schemes which improve upon the largest known gap between linear and non-linear Network Coding, thus improving the results of. The proofs are based on a relation between this problem and results in the study of Witsenhausen's rate, OR graph products, colorings of Cayley graphs, and the chromatic numbers of Kneser graphs.
Statistical Tuning of the Best suited Prediction Model for Measurements made in Hyderabad City of Southern India

 Abstract— The demand for increased mobile phone subscribers requires an efficient radio network planning that involves an accurate prediction of path loss. Although various empirical path loss models are in use, they are suitable for a particular environment or a specific cell radius. In this paper, GSM 900 MHz mobile signals that are recorded experimentally, for five base stations in Hyderabad city, are considered for path loss analysis. The measured path loss is determined from the collected field strength data. Three standard prediction models namely, Cost-231 Hata model, ECC-33 model and SUI model are implemented. Based on the comparison of measured and predicted path loss exponents, Cost-231 Hata model is identified as the best suited model. In order to improve the prediction accuracy, this model is statistically tuned using Least Square algorithm. The initial offset parameter and slope of the model curve in Cost-231 Hata model are considered for tuning and new model parameters are estimated. The performance of the tuned model is evaluated using mean square error, root mean square error, standard deviation and relative error. The error statistics are estimated for the tuned model as well as the prediction models. The tuned model gives a mean error of 1.294, root mean square error of 4.764, standard deviation of 4.29 and a relative error of 12.75%. The results show that the errors are least for the tuned Cost-231 Hata model, compared to the implemented empirical models. This successfully validates the tuning methodology and suggests that the tuned model is more accurate for the specified environment.
Why Do the Relativistic Masses and Momenta of Faster-than-Light Particles Decrease as their Speeds Increase?

It has recently been shown within a formal axiomatic framework using a definition of four-momentum based on the Stuckelberg- Feynman-Sudarshan-Recami ''switching principle'' that Einstein's relativistic dynamics is logically consistent with the existence of interacting faster-than-light inertial particles. Our results here show, using only basic natural assumptions on dynamics, that this definition is the only possible way to get a consistent theory of such particles moving within the geometry of Minkowskian spacetime. We present a strictly formal proof from a streamlined axiom system that given any slow or fast inertial particle, all inertial observers agree on the value of m⋅|1−v2|−−−−−−√, where m is the particle's relativistic mass and v its speed. This confirms formally the widely held belief that the relativistic mass and momentum of a positive-mass faster- than-light particle must decrease as its speed increases.
In the Room with Milton H. Erickson, M.D. Volume 1 (October 3rd–5th, 1979), by Milton Erickson

This article summarizes the state-of-science knowledge regarding the associations between hypnosis and brain oscillations. Brain oscillations represent the combined electrical activity of neuronal assemblies, usually measured as specific frequencies representing slower (delta, theta, alpha) and faster (beta, gamma) oscillations. Hypnosis has been most closely linked to power in the theta band and changes in gamma activity. These oscillations are thought to play a critical role in both the recording and recall of declarative memory and emotional limbic circuits. The authors propose that this role may be the mechanistic link between theta (and perhaps gamma) oscillations and hypnosis, specifically, that the increases in theta oscillations and changes in gamma activity observed with hypnosis may underlie some hypnotic responses. If these hypotheses are supported, they have important implications for both understanding the effects of hypnosis and for enhancing response to hypnotic treatments.
Physiological pattern changes in response to a simulated competition in elite women artistic gymnasts.

The outstanding progress in women's artistic gymnastics in recent decades has led to increased technical and physiological demands. The aim of this study was to investigate i) the physiological demands of elite French gymnasts and ii) the impact of a competitive routine on physiological pattern changes. Fourteen French elite female gymnasts performed anthropometric measurements, physical fitness tests and a simulated four event competition. Heart rate (HR) was continuously recorded throughout the duration of the simulated competition. Blood lactate concentrations were assessed at rest, before the beginning and at 2, 4 and 10 min after completion of the routine on each apparatus. Isometric handgrip strength and anaerobic endurance and power were assessed during the simulated competition. The highest values of HR and blood lactate concentrations were reached during the floor and uneven bar exercises. Blood lactate concentrations and HR kinetics were apparatus dependent and values remained significantly increased at 10 min of recovery compared with resting data. Anaerobic endurance and power decreased significantly as the competition progressed (P <0.001). The present results show specifically cardiorespiratory and anaerobic apparatus- dependent responses throughout a simulated competition. Recovery approaches appear relevant to prevent and/or minimize fatigue and optimize performance in these athletes.
Strategic network formation with structural holes

A fundamental principle in social network research is that individuals can benefit from serving as intermediaries between others who are not directly connected. Through such intermediation, they potentially can broker the flow of information and synthesize ideas arising in different parts of the network. These principles form the underpinning for the theory of structural holes, which studies the ways in which individuals, particularly in organizational settings, fill the "holes" between people or groups that are not otherwise interacting. We apply a game-theoretic approach to this notion, studying the structures that evolve when individuals in a social network have incentives to form links that bridge otherwise disconnected parties. We model payoffs as a trade-off between the benefits of connecting non-neighboring nodes, and the cost, in effort, to maintain links - including settings where the costs are non-uniform to reflect the increased difficulty in spanning different parts of a hierarchical organization. We find, both through theoretical results and computational experiments, that the equilibrium networks in this model have rich combinatorial structure, and capture qualitative observations arising in the study of structural holes. In particular, even in completely symmetric settings, individuals will differentiate themselves in equilibrium, occupying different social strata and receiving correspondingly different payoffs.
Hot-electron and hole-emission effects in short n-channel MOSFET's

This paper presents a comparison of hot-carrier degradation experiments with simulations of hot electron and hole emission into the oxide. It is shown that both the emission of holes and of electrons are essential to explain the dominant generation of negative charge by a new degradation mechanism. Moreover, a peak of positive-charge generation at a gate voltage close to threshold was found in our experiments which is due to hole trapping. A simple degradation model based on the calculated electron and hole emission is presented which gives a very good description of the observed behavior of degradation effects.
A Comprehensive Analysis of Human Motion Capture Data for Action Recognition

In this paper, we present an analysis of human motion that can assist the recognition of human actions irrespective of the selection of particular features. We begin with an analysis on the entire set of preclassified motions in order to derive the generic characteristics of articulated human motion and complement the analysis by a more detailed inter-class analysis. The statistical analysis concerns features that describe the significancecontribution of the human joints in performing an action. Furthermore, we adopt a hierarchical analysis on the human body itself in the study of different actions, by grouping joints that share common characteristics. We present our experiments on standard databases for human motion capture data as well as a new commercial dataset with additional classes of human motion and highlight certain interesting results.
Improved smoothed analysis of the k-means method

To determine some spatial characteristic, such as size or shape, of an object, the object is viewed with a television camera that employs an image sensor such as a CCD device. An image is formed on a television screen and a set of measurement markers (or cursors) are superimposed on the image at desired positions. The CCD timing signals are used to accurately determine the position of the cursors and hence the desired spatial characteristic.
Environmental Effects on Thermal Properties of PEI/Glass Fiber Composite Materials

The aim of this study was to investigate the effects of hygrothermal exposure, ultraviolet (UV) radiation, salt spray and thermal shock aging on the thermomechanical behavior of glass fiber reinforced by poly (ether-imide) (PEI) composites. Dynamic mechanical (DMA) and Thermomechanical (TMA) analyses have been performed on the aged PEI composites after being submitted to the climatic chambers. Additional techniques have been used to characterize the laminates, such as optical microscopy and infrared spectroscopy (FT-IR) in order to evaluate possible structural changes in these materials. Slight changes were observed both in glass transition temperature and in thermal expansion coefficient as a result from the environmental conditioning used (hygrothermal, salt spray, UV radiation and thermal shock conditioning). Thus, when exposed to these conditions, PEI/glass fiber laminates maintain its compromise with the performance component.
Angiography : A Randomized Controlled Trial CoronaryWith Homocysteine-Lowering B Vitamins After Mortality and Cardiovascular Events in Patients Treated

Supplementary material http://jama.ama-assn.org/cgi/content/full/300/7/795/DC1 Report Video JAMA Correction Contact me if this article is corrected. Citations Contact me when this article is cited. Topic collections Contact me when new articles are published in these topic areas. Myocardial Infarction; Venous Thromboembolism Trial; Stroke; Angiology; Cardiovascular System; Cardiovascular Disease/ Radiologic Imaging; Neurology; Cerebrovascular Disease; Randomized Controlled
Electronic and Magnetic Structure under Lattice Distortion in SrIrO3/SrTiO3 Superlattice: A First-Principles Study

Motivated by recent experiments on (001) [SrIrO3]m/[SrTiO3]1 superlattice (J. Matsuno, et al., arXiv:1401.1066), we perform first-principles calculations to study the electronic and magnetic structure of this superlattice under lattice distortion. We consider two different magnetic structures, a non-collinear in-plane canted antiferromagnetic (AFM) order and a collinear AFM order along c direction, and find that these two AFM states exhibit different strain dependence. The canted AFM order is enhanced with compressive strain while the collinear AFM order is enhanced with tensile strain. Moreover, the local magnetic moments of these magnetic structures show different linear dependence with respect to compressive or tensile epitaxial strain. We also find that the electronic band structure is sensitive to strain, local rotation, and ab-plane Ir-O bond length. Under a certain condition of lattice distortion, the band gap is even closed to induce an effective total angular momentum Jeff = 1/2 metal. These unexpected behaviors deserve more careful investigation on the microscopic mechanism played by a strong spin-orbit coupling, electron correlations, and lattice distortion.
Clinical trial of sertraline in the treatment of night eating syndrome.

OBJECTIVE To test the efficacy of sertraline in the treatment of night eating syndrome. METHODS Seventeen patients meeting criteria for night eating syndrome received sertraline in a 12-week open-label, nonblind trial. Outcome was assessed by four primary measures, namely, the number of nocturnal awakenings, the number of ingestions, total daily caloric intake after the evening meal, and an overall rating of change from the Clinical Global Impression of Improvement scale (CGI-I). RESULTS AND DISCUSSION An intent-to-treat analysis revealed highly significant improvements across all four primary outcome measures for all 17 subjects. Five subjects achieved full remission of symptoms (CGI-I score of 1 = very much improved) and lost a significant amount of weight over the course of the study (-4.8 +/- 2.6 kg, p < .05). Sertraline, a selective serotonin reuptake inhibitor, may be beneficial in the treatment of night eating syndrome.
How does the good old Genetic Algorithm fare at real world optimization?

Genetic Algorithms (GAs) have been studied for more than three decades now. Their application in optimization problems is well understood and significant amount of research has gone into the development of efficient GA operators. Besides GAs, a number of other Evolutionary Algorithms (EAs) and their performance-enhancing variations have been proposed. However, this upgraded performance is often achieved at the undesirable cost of introducing additional user-defined parameters. In an attempt to put forward a case for GA even when a plethora of other EAs are available, we present the results obtained by using a Real-Coded, Elite preserving GA on the Real World optimization problems of IEEE CEC — 2011. Based on our preliminary investigations, we would like to stress that the current work shall help bring forth the need to take a step back to re-assess the applicability of basic GAs to practical optimization before yet another Bio-inspired algorithm is introduced.
Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA.DNA oligonucleotide.

An experimental strategy to facilitate correction of single-base mutations of episomal targets in mammalian cells has been developed. The method utilizes a chimeric oligonucleotide composed of a contiguous stretch of RNA and DNA residues in a duplex conformation with double hairpin caps on the ends. The RNA/DNA sequence is designed to align with the sequence of the mutant locus and to contain the desired nucleotide change. Activity of the chimeric molecule in targeted correction was tested in a model system in which the aim was to correct a point mutation in the gene encoding the human liver/bone/kidney alkaline phosphatase. When the chimeric molecule was introduced into cells containing the mutant gene on an extrachromosomal plasmid, correction of the point mutation was accomplished with a frequency approaching 30%. These results extend the usefulness of the oligonucleotide-based gene targeting approaches by increasing specific targeting frequency. This strategy should enable the design of antiviral agents.
Well-being and the Complexity of Poverty: A Subjective Well-being Approach

This investigation studies human well-being from a subjective well-being approach. On the basis of a Mexican database the investigation shows that there is a weak relationship between subjective well-being and indicators of well-being such as income and consumption. Therefore, subjective well-being provides additional useful information to study human well-being and, in consequence, poverty. Three reasons for the existence of a weak relationship are studied: First, the fact that a person is much more than a consumer; second, the role of heterogeneity in human perceptions; and third, the existence of heterogeneity in purposes of life. The understanding and abatement of poverty would be better served by a concept of human well-being which incorporates subjective well-being indicators and which is based on the wholeness and complexity of human beings.
The Effects of On-site Measured Ozone Concentration on Pulmonary Function and Symptoms of Asthmatics

Most studies on the effects of ambient ozone on asthmatics have been based on ozone concentration measurements taken by air monitors in downtown areas. Using a passive ozone sampler, we investigated the effects of on-site ozone concentrations on the pulmonary function and symptoms of asthmatics. Twenty moderate to severe asthmatics who had been managed for at least 2 months without changes of their medication were enrolled from 3 June to 18 July 2005. Respiratory, nasal and ocular symptoms, peak expiratory flow (PEF), which was measured twice a day, and medication use were recorded on a daily basis during the study period. Data for 17 subjects were analyzed. The average ozone exposure level was 28.2±23.6 ppb (3.4-315.3 ppb). There was no significant correlation between PEF and ozone concentration (p>0.05) on the same day or 1-, 2-, or 3-day lags. Interestingly, the degree of asthma symptoms was influenced by the ozone concentration (ρ=0.303, p<0.001), even at concentrations less than 80 ppb (p=0.298, p<0.001), but the correlation between ozone exposure and the frequency of reliever medication use was not statistically significant (p=0.99). Our results suggest that exposure to relatively low concentrations of ozone influences the symptoms of moderate to severe asthmatics regardless of changes in pulmonary function or medication use.
Human Milk Contains Novel Glycans That Are Potential Decoy Receptors for Neonatal Rotaviruses*

Human milk contains a rich set of soluble, reducing glycans whose functions and bioactivities are not well understood. Because human milk glycans (HMGs) have been implicated as receptors for various pathogens, we explored the functional glycome of human milk using shotgun glycomics. The free glycans from pooled milk samples of donors with mixed Lewis and Secretor phenotypes were labeled with a fluorescent tag and separated via multidimensional HPLC to generate a tagged glycan library containing 247 HMG targets that were printed to generate the HMG shotgun glycan microarray (SGM). To investigate the potential role of HMGs as decoy receptors for rotavirus (RV), a leading cause of severe gastroenteritis in children, we interrogated the HMG SGM with recombinant forms of VP8* domains of the RV outer capsid spike protein VP4 from human neonatal strains N155(G10P[11]) and RV3(G3P[6]) and a bovine strain, B223(G10P[11]). Glycans that were bound by RV attachment proteins were selected for detailed structural analyses using metadata-assisted glycan sequencing, which compiles data on each glycan based on its binding by antibodies and lectins before and after exo- and endo-glycosidase digestion of the SGM, coupled with independent MSn analyses. These complementary structural approaches resulted in the identification of 32 glycans based on RV VP8* binding, many of which are novel HMGs, whose detailed structural assignments by MSn are described in a companion report. Although sialic acid has been thought to be important as a surface receptor for RVs, our studies indicated that sialic acid is not required for binding of glycans to individual VP8* domains. Remarkably, each VP8* recognized specific glycan determinants within a unique subset of related glycan structures where specificity differences arise from subtle differences in glycan structures.
Activity-Dependent Plasticity and Gene Expression Modifications in the Adult CNS

Information processing, memory formation, or functional recovery after nervous system damage depend on the ability of neurons to modify their functional properties or their connections. At the cellular/molecular level, structural modifications of neural circuits are finely regulated by intrinsic neuronal properties and growth-regulatory cues in the extracellular milieu. Recently, it has become clear that stimuli coming from the external world, which comprise sensory inflow, motor activity, cognitive elaboration, or social interaction, not only provide the involved neurons with instructive information needed to shape connection patterns to sustain adaptive function, but also exert a powerful influence on intrinsic and extrinsic growth-related mechanisms, so to create permissive conditions for neuritic remodeling. Here, we present an overview of recent findings concerning the effects of experience on molecular mechanisms underlying CNS structural plasticity, both in physiological conditions and after damage, with particular focus on activity-dependent modulation of growth-regulatory genes and epigenetic modifications.