Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation between LDH, Liver Function, Platelets and Proteinuria in Preeclampsia with Severe Features

Objectives: To identify the relationship between LDH, bilirubin, SGPT, SGOT, and platelets with proteinuria in preeclampsia with severe features patients. Method: This study is an observational analytical with a retrospective cross-sectional design. The samplings contain 70 patients from the medical records of patients who were diagnosed with preeclampsia with severe features at H. Adam Malik Hospital Medan from January 2020 to March 2023.Results: It was found that 74.3% of the population had semiquantitative urine protein levels ≥+2. The average levels of LDH, total bilirubin, SGPT, SGOT, and platelets were 514.64 U/L, 0.9 mg/dL, 57.77 U/L, 64.01 U/L, and 197,585/mm3, respectively. Statistical analysis showed a positive association between proteinuria and LDH (p=0.001). However, there was no meaningful association between liver and platelet function and proteinuria.Conclusion: There is a relationship between LDH and proteinuria in severe preeclampsia patients.Hubungan antara LDH, Fungsi Hati, Trombosit dengan Proteinuria pada Pasien Preeklamsia BeratAbstrakTujuan: Untuk mengidentifikasi hubungan antara LDH, bilirubin, SGPT, SGOT, dan trombosit dengan proteinuria pada pasien preeklampsia dengan gejala berat.Metode: Penelitian ini merupakan penelitian analitik observasional dengan desain potong lintang retrospektif. Sampel terdiri dari 70 pasien dari rekam medis pasien yang didiagnosis dengan preeklampsia berat di RSUP H. Adam Malik Medan pada periode Januari 2020 hingga Maret 2023.Hasil: Ditemukan bahwa 74,3% dari populasi memiliki kadar protein urin semikuantitatif ≥+2. Kadar rata-rata LDH, bilirubin total, SGPT, SGOT, dan trombosit masing-masing adalah 514,64 U/L, 0,9 mg/dL, 57,77 U/L, 64,01 U/L, dan 197.585/mm3. Analisis statistik menunjukkan hubungan positif antara proteinuria dan LDH (p=0,001). Namun, tidak ada hubungan yang bermakna antara fungsi hati dan trombosit dengan proteinuria.Kesimpulan: Terdapat hubungan antara LDH dan proteinuria pada pasien preeklampsia berat.Kata kunci: hemolisis, fungsi hati, trombosit, preeklamsia berat, proteinuria
Pathological Study of Rare Case of Duodenal Leiomyosarcoma in a Labrador Dog

The leiomyosarcoma is a tumor of mesenchymal origin of smooth, malignant, slow-growing muscles. The present study reports a case of duodenal leiomyosarcoma in Labrador dog. A 6 year old black female Labrador dog with history off feed, vomition and melena brought for necropsy examination. Gross lesions revealed tennis ball size tumorus mass at the initial portion of duodenum resulting into the obstruction of intestinal lumen. Microscopically, duodenum with tumours mass revealed smooth muscle bundles arranged in all the directions having elongated blunt ended nuclei along with numerous blood vessels and mitotic figure which is indicative of leiomyosarcoma.
Yersinia infection tools—characterization of structure and function of adhesins

Among the seventeen species of the Gram-negative genus Yersinia, three have been shown to be virulent and pathogenic to humans and animals—Y. enterocolitica, Y. pseudotuberculosis, and Y. pestis. In order to be so, they are armoured with various factors that help them adhere to tissues and organelles, cross the cellular barrier and escape the immune system during host invasion. The group of proteins that mediate pathogen–host interactions constitute adhesins. Invasin, Ail, YadA, YadB, YadC, Pla, and pH 6 antigen belong to the most prominent and best-known Yersinia adhesins. They act at different times and stages of infection complementing each other by their ability to bind a variety of host molecules such as collagen, fibronectin, laminin, β1 integrins, and complement regulators. All the proteins are anchored in the bacterial outer membrane (OM), often forming rod-like or fimbrial-like structures that protrude to the extracellular milieu. Structural studies have shown that the anchor region forms a β-barrel composed of 8, 10, or 12 antiparallel β-strands. Depending on the protein, the extracellular part can be composed of several domains belonging to the immunoglobulin fold superfamily, or form a coiled-coil structure with globular head domain at the end, or just constitute several loops connecting individual β-strands in the β-barrel. Those extracellular regions define the activity of each adhesin. This review focuses on the structure and function of these important molecules, and their role in pathogenesis.
ΔNp63 knockdown mice: A mouse model for AEC syndrome

Dominant mutations in TP63 cause ankyloblepharon ectodermal dysplasia and clefting (AEC), an ectodermal dysplasia characterized by skin fragility. Since ΔNp63α is the predominantly expressed TP63 isoform in postnatal skin, we hypothesized that mutant ΔNp63α proteins are primarily responsible for skin fragility in AEC patients. We found that mutant ΔNp63α proteins expressed in AEC patients function as dominant‐negative molecules, suggesting that the human AEC skin phenotype could be mimicked in mouse skin by downregulating ΔNp63α. Indeed, downregulating ΔNp63 expression in mouse epidermis caused severe skin erosions, which resembled lesions that develop in AEC patients. In both cases, lesions were characterized by suprabasal epidermal proliferation, delayed terminal differentiation, and basement membrane abnormalities. By failing to provide structural stability to the epidermis, these defects likely contribute to the observed skin fragility. The development of a mouse model for AEC will allow us to further unravel the genetic pathways that are normally regulated by ΔNp63 and that may be perturbed in AEC patients. Ultimately, these studies will not only contribute to our understanding of the molecular mechanisms that cause skin fragility in AEC patients, but may also result in the identification of targets for novel therapeutic approaches aimed at treating skin erosions. © 2009 Wiley‐Liss, Inc.
Detecting interpretable and accurate scale-invariant keypoints

This paper presents a novel method for detecting scale invariant keypoints. It fills a gap in the set of available methods, as it proposes a scale-selection mechanism for junction-type features. The method is a scale-space extension of the detector proposed by Förstner (1994) and uses the general spiral feature model of Bigün (1990) to unify different types of features within the same framework. By locally optimising the consistency of image regions with respect to the spiral model, we are able to detect and classify image structures with complementary properties over scale-space, especially star and circular shapes as interpretable and identifiable subclasses. Our motivation comes from calibrating images of structured scenes with poor texture, where blob detectors alone cannot find sufficiently many keypoints, while existing corner detectors fail due to the lack of scale invariance. The procedure can be controlled by semantically clear parameters. One obtains a set of keypoints with position, scale, type and consistency measure. We characterise the detector and show results on common benchmarks. It competes in repeatability with the Lowe detector, but finds more stable keypoints in poorly textured areas, and shows comparable or higher accuracy than other recent detectors. This makes it useful for both object recognition and camera calibration.
Islamic Boarding School Education and Its Renewal According to K.H. Abdullah Syukri Zarkasyi

Education is currently faced with problems of crime and deviant behavior, which hinder the effectiveness of teaching Islamic teachings. Effective educational management and experienced leaders are required. One solution is to implement an integrated curriculum as proposed by KH. Abdullah Syukri Zarkasyi in reforming Islamic boarding school education. This research aims to understand the concept of Islamic boarding school education and its renewal according to KH. Abdullah Syukri Zarkasyi. This type of research is qualitative, using the literature review method by obtaining data through journals, books, and documentaries and comparing, contrasting, and critiquing data using thematic analysis techniques. The research results show that according to K.H Abdullah Syukri Zarkasyi, good Islamic boarding school education is based on the values of the five souls of Islamic boarding schools and is total. The reform of Islamic boarding school education that he proposed was rooted in the concept of the five souls of Pondok Modern Darussalam Gontor. K.H. Abdullah Syukri Zarkasyi emphasized three fundamental things in this reform: the totality of life in education, integral education, and Islamic boarding school education orientation.
The Role of Vitamin D and Vitamin D Receptor in Immunity to Leishmania major Infection

Vitamin D signaling modulates a variety of immune responses. Here, we assessed the role of vitamin D in immunity to experimental leishmaniasis infection in vitamin D receptor-deficient mice (VDRKO). We observed that VDRKO mice on a genetically resistant background have decreased Leishmania major-induced lesion development compared to wild-type (WT) mice; additionally, parasite loads in infected dermis were significantly lower at the height of infection. Enzymatic depletion of the active form of vitamin D mimics the ablation of VDR resulting in an increased resistance to L. major. Conversely, VDRKO or vitamin D-deficient mice on the susceptible Th2-biased background had no change in susceptibility. These studies indicate vitamin D deficiency, either through the ablation of VDR or elimination of its ligand, 1,25D3, leads to an increase resistance to L. major infection but only in a host that is predisposed for Th-1 immune responses.
A ( DISCOURSE ) FUNCTIONAL ANALYSIS OF ASYMMETRIC COORDINATION

A long-standing puzzle in the analysis of coordination is the so-called SGF coordination (Subject Gap in Finite/Fronted constructions) in German, first discussed by Höhle (1983a). The syntactic analysis of SGF constructions is challenging for any type of syntactic framework, as they seem to violate basic assumptions of accessibility or distribution in coordination constructions. SGF constructions have been analysed in terms of asymmetrically embedded constituents (Wunderlich 1988; Höhle 1990; Heycock and Kroch 1993; Büring and Hartmann 1998) or symmetric conjuncts (Steedman 1990; Kathol 1995, 1999). Asymmetric embedding is problematic as it involves extraction asymmetries, or an analysis of coordination as adjunction. Symmetric analyses need to assume special licensing conditions that are not independently motivated. In particular, we argue that the symmetric analysis of Kathol (1999) is lacking independent syntactic motivation, and fails to account for related asymmetric coordinations of verb-last and verb-fronted (VL/VF) sentences. We present a multi-factorial LFG analysis of asymmetric coordination, building on independently motivated principles of correspondence between c–structure, f–structure, and i(nformation)–structure. SGF coordination is analysed as symmetric coordination in c–structure. Binding of the (prima facie) inaccessible subject of the first conjunct is enabled, at the level of f–structure, by asymmetric projection of a ”grammaticalised discourse function (GDF)”, a TOPIC, FOCUS or SUBJ function (Bresnan 2001). Asymmetric GDF projection is motivated by relating the semantic and discourse-functional properties of asymmetric coordination to well-known discourse subordination effects of modal subordination (Frank 1997; Frank and Kamp 1997). In conjunction with word order constraints in the optimality model of Choi (2001), our analysis explains the mysterious word order constraints of asymmetric coordination, and some puzzling scoping properties.
Perceptions, quality and motivational needs in image tagging human computation games

Human computation games (HCGs) are applications that use games to harness human intelligence to perform various computational tasks. That is, users perform computations as a byproduct of being entertained while playing a game. Such games are increasing in popularity and it is critical to examine how different types of HCG affect players’ perceptions and performance. In addition, understanding their motivational appeal to different players is also important to good HCG design. In the present research, we focus on image tagging HCGs, where users play games to generate keywords for images. Three versions were created: a collaborative HCG which required players to cooperate, a competitive HCG where players worked against each other, and a control non-game manual tagging application. The applications were evaluated to uncover the quality of the tags, users’ perceptions of these variants, and the influence of motivational needs on usage intention. Results suggest that, while participants reported liking the collaborative and competitive HCGs over the control application, those using the latter seemed to generate better quality tags. Further, using the trichotomy of needs theory, we found that an individual’s need for achievement and power influenced intention to use the various applications.
The Antarctic Atmospheric Energy Budget. Part II: The Effect of Ozone Depletion and its Projected Recovery

AbstractIn this study the authors continue their investigation of the atmospheric energy budget of the Antarctic polar cap (the region poleward of 70°S) using integrations of the Whole Atmosphere Community Climate Model from the years 1960 to 2065. In agreement with observational data, it is found that the climatological mean net top-of-atmosphere (TOA) radiative flux is primarily balanced by the horizontal energy flux convergence over the polar cap. On interannual time scales, changes in the net TOA radiative flux are also primarily balanced by changes in the energy flux convergence, with the variability in both terms significantly correlated (positively and negatively, respectively) with the southern annular mode (SAM). On multidecadal time scales, twentieth-century stratospheric ozone depletion produces a negative trend in the net TOA radiative flux due to a decrease in the absorbed solar radiation within the atmosphere–surface column. The negative trend in the net TOA radiative flux is balanced by a p.
Different Permeability of Potassium Salts across the Blood-Brain Barrier Follows the Hofmeister Series

The passage of ions across biological membranes is regulated by passive and active mechanisms. Passive ion diffusion into organs depends on the ion-pairing properties of salts present in the serum. Potassium ions could affect brain activity by crossing the blood-brain barrier (BBB) and its accumulation in the extracellular cerebral space could precipitate seizures. In the present study, we analyze passive diffusion of a series of potassium salts in the in vitro isolated guinea pig brain preparation. Different potassium counter-anions confer ion-pairing and lipophilicity properties that modulate membrane diffusion of the salt. Extracellular recordings in different cortical areas demonstrated the presence of epileptiform activities that strongly relate to anion identity, following the qualitative order of the Hofmeister series. Indeed, highly lipophilic salts that easily cross the BBB enhanced extracellular potassium concentration measured by ion-selective electrodes and were the most effective pro-epileptic species. This study constitutes a novel contribution for the understanding of the potential epileptogenicity of potassium salts and, more generally, of the role of counter-anions in the passive passage of salts through biological membranes.
Method to Achieving High-Power Microwaves in Air and Argon

The paper summarizes the results of the microwave generation in atmospheric air and argon at high pressure. The method how to proceed to achieving higher power level is presented. Two experimental setups were considered. Attention is paid to the interactions between the frequencies in the resonant cavity i.e., the coherence effect. The objective is to get reproducible data and the generation of the microwave emission at the single frequency to avoid the coherence effect. The electrons in the cavity are created by the electric field and by the photoionization, enabling the population inversion to be obtained. Because of the electron impact with N2 in air, molecules cannot lose this energy by photon emission, their excited vibrational levels are metastable and live for a long time. The microwave pulse of long duration can be generated. The various radiation lines created in the resonant cavity are noted. To achieve high-power microwave emission, the resonant cavity has to be tuned to the more powerful line of the rotational and/or vibrational transition of molecules in air occurring at high frequency and not at 1-GHz frequency used in this study. A compact system could be achieved by using the high-frequency line. The study points out that the microwaves are produced through the amplification by stimulated emissions of electromagnetic radiation (maser action) in air and argon.
Energy-efficient pilot and data power allocation in massive multi-user multiple-input multiple-output communication systems

This study aims to improve the energy efficiency of time-division duplexing massive multi-user multiple-input multiple-output communication systems for both uplink and downlink transmissions. By using minimum mean square error channel estimation, two novel pilot–data power allocation schemes are proposed to minimise the total uplink and downlink transmit power under per-user signal-to-interference-plus-noise ratio (SINR) requirement and per-user power consumption constraints. The proposed schemes take into account the maximum-ratio combining and zero-forcing (ZF) detectors in the uplink transmission together with maximum-ratio transmission and ZF precoder in the downlink transmission. In order to simplify the proposed optimisation problems, lower bounds of the average SINR are derived and used in the power allocation algorithms. The key contribution of this study lies in formulating the original energy-efficient power allocation problem and converting such a complicated optimisation problem to a geometric programming problem. Computer simulation validates the tightness of the derived SINR lower bounds and shows that the proposed schemes can save up to 78% of the total power as compared with the equal power allocation among all the mobile users.
Genetic and Environmental Dissections of Sub-Phenotypes of Metabolic Syndrome in the Chinese Population: A Twin-Based Heritability Study

Objective: We perform a comprehensive heritability study on multiple phenotypes related to metabolic syndrome using Chinese twins to assess the genetic and environmental effects in determining the variation and covariation of the phenotypes in the Chinese population. Methods: The studied sample contains 654 twins collected in the Qingdao municipality. A total of 10 phenotypes covering anthropometric measurements, plasma glucose levels, lipids, blood pressures etc. were examined. Univariate and bivariate structural equation models were fitted for assessing the genetic and environmental contributions. Results: The AE model combining additive genetic (A) and unique environmental (E) factors produced the best fit for all phenotypes except for triglyceride. Modest to high heritability estimates were obtained in univariate analysis ranging from 0.5 for total cholesterol to 0.78 for weight. The bivariate model estimated high genetic correlations between systolic and diastolic blood pressures, between total cholesterol and low density lipoprotein cholesterol, modest genetic correlations between BMI and blood pressures. No significant common environmental correlation was found between any pair of the phenotypes. Conclusions: Our results showed significant genetic contributions to the sub-phenotypes of metabolic syndrome. Although pleiotropic genetic control may exist for some physiologically similar phenotypes, our results do not support a common genetic mechanism among the phenotypes covered in our study.
Plateau in Core Temperature during Shorter but Not Longer Work/Rest Cycles in Heat

This study compared physiological responses to two work/rest cycles of a 2:1 work-to-rest ratio in a hot environment. In a randomized crossover design, fourteen participants completed 120 min of walking and rest in the heat (36.3 ± 0.6 °C, 30.2 ± 4.0% relative humidity). Work/rest cycles were (1) 40 min work/20 min rest [40/20], or (2) 20 min work/10 min rest [20/10], both completing identical work. Core temperature (Tc), skin temperature (Tsk), heart rate (HR), nude body mass, and perception of work were collected. Comparisons were made between trials at equal durations of work using three-way mixed model ANOVA. Tc plateaued in [20/10] during the second hour of work (p = 0.93), while Tc increased in [40/20] (p < 0.01). There was no difference in maximum Tc ([40/20]: 38.08 ± 0.35 °C, [20/10]: 37.99 ± 0.27 °C, p = 0.22) or end-of-work Tsk ([40/20]: 36.1 ± 0.8 °C, [20/10]: 36.0 ± 0.7 °C, p = 0.45). End-of-work HR was greater in [40/20] (145 ± 25 b·min−1) compared to [20/10] (141 ± 27 b·min−1, p = 0.04). Shorter work/rest cycles caused a plateau in Tc while longer work/rest cycles resulted in a continued increase in Tc throughout the work, indicating that either work structure could be used during shorter work tasks, while work greater than 2 h in duration may benefit from shorter work/rest cycles to mitigate hyperthermia.
Virtual human technology: patient demographics and healthcare training factors in pain observation and treatment recommendations

Background Patients’ sex, race, and age have been found to affect others’ perception of their pain. However, the influence of these characteristics on treatment recommendations from laypersons and healthcare providers is understudied. Design To address this issue, 75 undergraduates and 107 healthcare trainees (HTs) used a web-based delivery system to view video clips of virtual human (VH) patients presenting with different standardized levels of pain. Subjects then rated the VHs’ pain intensity and recommended the amount of medical treatment the VHs should receive. Results Results indicated that, compared with undergraduates, HTs perceived African Americans and older adults as having less pain but were more willing to recommend medical treatment for these patients than were undergraduate participants. HTs and undergraduates rated female, African American, older, and high-pain-expressing adults as having greater pain intensity than male, Caucasian, younger, and lower-pain-expressing adults. Moreover, they also recommended that female, older, and high-pain-expressing adults receive more medical treatment than male, younger, and lower-pain-expressing adults. Conclusions This study found that the characteristics of the VHs and whether the participants were undergraduates or HTs influenced the ratings of pain assessment and treatment recommendations. The findings are consistent with the previous VH literature showing that VH characteristics are important cues in the perception and treatment of pain. However, this is the first study to identify differences in pain-related decisions between individuals who are pursuing healthcare careers and those who are not. Finally, not only does this study serve as further evidence for the validity and potential of VH technology but also it confirms prior research that has shown that biases regarding patient sex, race, and age can affect pain assessment and treatment.