Miracle-dz/UniFAR-FTUs huggingface dataset:
CONSERVAÇÃO EX SITU E POMAR DE SEMENTES EM BANCO DE GERMOPLASMA DE Balfourodendron riedelianum

A conservação ex situ tem sido adotada como uma estratégia para preservar populações de espécies em risco de extinção. Os objetivos deste trabalho foram investigar a variação genética para caracteres quantitativos e a seleção dentro de progênies, em um banco de conservação ex situ de Balfourodendron riedelianum, implantado na Estação Experimental de Luiz Antônio na forma de teste de procedências e progênies. O delineamento adotado foi o de blocos de famílias compactas, com 3 procedências, 19 progênies por procedência, 6 repetições e 5 plantas por subparcelas. O teste foi mensurado aos 21 anos de idade para o DAP, altura, forma do fuste, volume e sobrevivência. Foram detectadas diferenças significativas entre procedências para DAP, forma do fuste e volume, e entre progênies dentro de procedências para DAP, altura e volume. As estimativas da diferenciação genética entre e dentro de procedências indicou que a maior parte da variação genética (> 95%) se encontra dentro de procedências. Os coeficientes de herdabilidade em nível de plantas individuais e dentro de progênies foram baixos para os caracteres (variando de 0,001 a 0,067), sugerindo baixo potencial para a seleção massal no experimento ou dentro de progênies. O coeficiente de herdabilidade em nível de média de progênies foi substancial para DAP (0,290) e volume (0,331), sugerindo que as procedências têm variação herdável para responder à seleção natural. A estimativa do número status para o conjunto das procedências foi alta, tanto antes ( Ns ˆ = 124,3) como após a seleção ( Ns ˆ = 106,9), indicando que um alto potencial evolutivo foi retido no banco de germoplasma e será mantido após a seleção. Os resultados também sugerem que sementes colhidas no pomar proposto conterão alta variabilidade genética e baixa endogamia
Tuberculosis and diabetes in southern Mexico.

OBJECTIVE To determine the impact of diabetes on the rates of tuberculosis in a region where both diseases are prevalent. RESEARCH DESIGN AND METHODS Data from a population-based cohort of patients with pulmonary tuberculosis undergoing clinical and mycobacteriologic evaluation (isolation, identification, drug-susceptibility testing, and IS6110-based genotyping and spoligotyping) were linked to the 2000 National Health Survey (ENSA2000), a national probabilistic, polystage, stratified, cluster household survey of the civilian, noninstitutionalized population of Mexico. RESULTS From March 1995 to March 2003, 581 patients with Mycobacterium tuberculosis culture and fingerprint were diagnosed, 29.6% of whom had been diagnosed previously with diabetes by a physician. According to the ENSA2000, the estimated prevalence of diabetes in the study area was 5.3% (95% CI 4.1-6.5). The estimated rates of tuberculosis for the study area were greater for patients with diabetes than for nondiabetic individuals (209.5 vs. 30.7 per 100000 person-years, P < 0.0001). CONCLUSIONS In this setting, the rate of tuberculosis was increased 6.8-fold (95% CI 5.7-8.2, P < 0.0001) in patients with diabetes due to increases in both reactivated and recently transmitted infection. Comorbidity with diabetes may increase tuberculosis rates as much as coinfection with human immunodeficiency virus (HIV), with important implications for the allocation of health care resources.
Bankruptcy and low cost carrier expansion in the airline industry

This paper studies how financial distress affects competition and how incumbent bankruptcy affects the growth of rivals, specifically in the context of airline bankruptcies. I begin by studying whether bankrupt airlines put competitive pressures on rivals by cutting fares and maintaining or expanding capacity on the 1000 most popular domestic routes from 1998-2008. The results suggest that, although bankrupt legacy airlines reduce fares, they also reduce capacities significantly. Low-cost carrier (LCC) rivals do not match the fare cuts and expand capacities by 13-18% above trend growth. The significant capacity reductions associated with legacy airline bankruptcies create growth opportunities for LCC rivals. This indicates the existence of barriers that have limited LCCs from expanding faster and more extensively. The LCC expansion during rivals' bankruptcies is even greater when I consider the 200 most popular airports instead of the 1000 most popular routes. During legacy airlines' bankruptcy, non-LCC rivals reduce capacities on the routes affected by the bankruptcy but expand at the affected airports. A likely explanation for this result is that non-LCCs avoid 'bankruptcy' routes as more competitive pressure is expected with increasing presence of LCCs, but they pick up the gates or time slots given up by the bankrupt airlines to expand on other routes. On balance the total route capacity on the 1000 popular routes shows only a modest decrease during bankruptcy and eventually recovers, but the capacity mix changes in favor of LCCs. Overall, I find little evidence that distressed airlines toughen competition and lower industry profitability. LCC's capacity growth during legacy rivals' bankruptcy suggests the existence of market frictions in competition.
Cosmology at the boundary of de Sitter using the dS/QFT correspondence

Using the dS/QFT correspondence in the context of inflation allows for the study of interesting, otherwise inaccessible physics. In particular, by studying inflation via its dual field theory at the boundary of the de Sitter space, it may be possible to study a regime of strongly coupled gravity at early times. The purpose of this work is to completely express cosmological observables in terms of the free parameters of a dual field theory and to compare them with CMB data. In this way, constraints on the observational parameters constrains the validity of the strongly coupled inflation picture by imposing limits on the parameters of the field theory. The fit with data defines a limit for the consistency and validity of the approach taken and shows that, within this limit, the model is almost unconstrained, but quite predictive, producing power spectra of density perturbations extremely near scale invariance.
Intraperitoneal Local Anesthetics Have Predominant Local Analgesic Effect: A Randomized, Double-blind Study

Background:It remains unclear whether analgesia from intraperitoneal local anesthetics is via local or central mechanisms. This double-blind clinical trial tests the hypothesis that intraperitoneal local anesthetic is superior to continuous IV infusion for pain management. Primary outcome was morphine consumption during 0 to 24 h. Methods:Informed consent was obtained from 60 patients, age 30 to 75 yr, American Society of Anesthesiologists physical status I to II, undergoing abdominal hysterectomy. A computer-generated program randomized patients in parallel arms to group IV: continuous infusion of lidocaine 50 mg/h (10 ml) IV and saline 10 ml/h intermittently intraperitoneal; group IP: injection of lidocaine 50 mg/h (10 ml) once every hour intraperitoneally and continuous infusion of saline 10 ml/h intravenously; and group P (placebo): saline 10 ml/h both intravenously and intermittent intraperitoneal injection. Postoperative morphine consumption, pain intensity, recovery, home discharge, and lidocaine concentrations were measured. Results:Morphine consumption during 0 to 24 h was lower in group IP versus group IV, mean difference −22.6 mg (95% CI, 11.4 to 33.8; P < 0.01). No difference was seen between group IV and group P. The total mean plasma concentration of lidocaine in group IP was significantly lower than group IV, 0 to 4.5 h postoperatively (P = 0.03) with no evidence of systemic toxicity. Pain intensity and other recovery parameters were similar between the groups. Conclusion:The lower supplemental morphine consumption and plasma lidocaine concentration in group IP would confirm that the effects of local anesthetics are likely to be predominant via local intraperitoneal receptors or anti-inflammatory effects and not via central mechanisms alone.
A taxonomy of human grasping behavior suitable for transfer to robotic hands

As a first step towards transferring human grasping capabilities to robots, we analyzed the grasping behavior of human subjects. We derived a taxonomy in order to adequately represent the observed strategies. During the analysis of the recorded data, this classification scheme helped us to obtain a better understanding of human grasping behavior. We will provide support for our hypothesis that humans exploit compliant contact between the hand and the environment to compensate for uncertainty. We will also show a realization of the resulting grasping strategies on a real robot. It is our belief that the detailed analysis of human grasping behavior will ultimately lead to significant increases in robot manipulation and dexterity.
Scalable routing strategies for ad hoc wireless networks

We consider a large population of mobile stations that are interconnected by a multihop wireless network. The applications of this wireless infrastructure range from ad hoc networking (e.g., collaborative, distributed computing) to disaster recovery (e.g., fire, flood, earthquake), law enforcement (e.g., crowd control, search-and-rescue), and military (automated battlefield). Key characteristics of this system are the large number of users, their mobility, and the need to operate without the support of a fixed (wired or wireless) infrastructure. The last feature sets this system apart from existing cellular systems and in fact makes its design much more challenging. In this environment, we investigate routing strategies that scale well to large populations and can handle mobility. In addition, we address the need to support multimedia communications, with low latency requirements for interactive traffic and quality-of-service (QoS) support for real-time streams (voice/video). In the wireless routing area, several schemes have already been proposed and implemented (e.g., hierarchical routing, on-demand routing, etc.). We introduce two new schemes-fisheye state routing (FSR) and hierarchical state routing (HSR)-which offer some competitive advantages over the existing schemes. We compare the performance of existing and proposed schemes via simulation.
Hepatitis B virus infection and immunization status in a new generation of injection drug users in San Francisco

Summary. Hepatitis B virus (HBV) infection is common among injection drug users (IDU). Younger IDU, however, may be less susceptible to infection due to the implementation of public health interventions, such as universal immunization programs and syringe exchange programs. To investigate the current epidemiology of HBV infection and control among a new generation of drug users in the United States, we conducted interviews and examined HBV serologic markers in a cross‐section of street‐recruited IDU under age 30 in San Francisco, CA. Of the 831 persons studied, 21% showed serologic evidence of current or past infection; 22% had isolated antibodies to hepatitis B surface antigen consistent with vaccine‐mediated immunity; and 56% had no HBV markers. In multivariate analyses, HBV infection was associated with drug use behaviour in heterosexual males; sexual behaviour in males who have sex with males; and both drug use and sexual behaviour in females. Vaccine‐mediated immunity was independently associated with female sex and younger age. In conclusion, HBV transmission persists among young IDU in San Francisco. Few young injectors show evidence of successful immunization and the majority remains susceptible to disease. Until the broad effects of universal vaccination are seen, targeted and innovative approaches to immunizing young IDU in the US are needed to prevent a substantial number of new HBV infections.
Recognition of Spatial Relations in Mathematical Formulas

A critical issue in recognition of mathematical expressions is the identification of the spatial relations of the symbols or/and sub-expressions that comprise the entire mathematical formula. This paper addresses the problem of structural analysis of mathematical expressions by constructing appropriate feature vectors to represent the spatial affinity of the objects (mathematical symbols or sub-expressions) under examination and employing two popular machine learning techniques: (i) Support Vector Machines (SVM) and (ii) Artificial Neural Networks (ANN) to recognize the spatial relation between these objects. In order to evaluate the proposed techniques, we use Math Brush, a large publicly available dataset of mathematical expressions with annotated spatial relations, and a subset of spatial relations derived from the mathematical expressions the CROHME 2012 dataset. The experimental results give an overall mean error rate of 2.8% for the SVM and 3.4% for the ANN classifiers respectively, which are at par with other approaches evaluated on the same datasets.
Exposing Racial Discrimination: Implicit & Explicit Measures–The My Body, My Story Study of 1005 US-Born Black & White Community Health Center Members

Background To date, research on racial discrimination and health typically has employed explicit self-report measures, despite their potentially being affected by what people are able and willing to say. We accordingly employed an Implicit Association Test (IAT) for racial discrimination, first developed and used in two recent published studies, and measured associations of the explicit and implicit discrimination measures with each other, socioeconomic and psychosocial variables, and smoking. Methodology/Principal Findings Among the 504 black and 501 white US-born participants, age 35–64, randomly recruited in 2008–2010 from 4 community health centers in Boston, MA, black participants were over 1.5 times more likely (p<0.05) to be worse off economically (e.g., for poverty and low education) and have higher social desirability scores (43.8 vs. 28.2); their explicit discrimination exposure was also 2.5 to 3.7 times higher (p<0.05) depending on the measure used, with over 60% reporting exposure in 3 or more domains and within the last year. Higher IAT scores for target vs. perpetrator of discrimination occurred for the black versus white participants: for “black person vs. white person”: 0.26 vs. 0.13; and for “me vs. them”: 0.24 vs. 0.19. In both groups, only low non-significant correlations existed between the implicit and explicit discrimination measures; social desirability was significantly associated with the explicit but not implicit measures. Although neither the explicit nor implicit discrimination measures were associated with odds of being a current smoker, the excess risk for black participants (controlling for age and gender) rose in models that also controlled for the racial discrimination and psychosocial variables; additional control for socioeconomic position sharply reduced and rendered the association null. Conclusions Implicit and explicit measures of racial discrimination are not equivalent and both warrant use in research on racial discrimination and health, along with data on socioeconomic position and social desirability.
Two components of transmitter release from the chick ciliary presynaptic terminal and their regulation by protein kinase C

1 A study was made of the effects of phorbol ester (phorbol 12‐myristate 13‐acetate, PMA, 0·1 μM) on the two components of evoked transmitter release, namely the fast synchronous and the slow asynchronous components, from the giant presynaptic terminal of the chick ciliary ganglion. The excitatory postsynaptic currents (EPSCs) were recorded under whole‐cell voltage clamp of the postsynaptic neuron. 2 The decay time constant of the slow component was prolonged by replacing Ca2+ with Sr2+. In 5 mM [Sr2+]o the fast component decayed with a time constant of 2·6 ± 1·4 ms whereas the slow component decayed with a time constant of 19 ± 7 ms. 3 When stimulated with twin pulses with a short interpulse interval, the fast component of the second EPSC was often depressed whereas the slow component was usually facilitated. Both components were positively dependent on [Sr2+]o in a saturable manner, but the fast component approached its maximum at a lower [Sr2+]o than the slow component. 4 PMA potentiated both the fast and slow components to a similar extent and with a similar time course. For each component, the effect of PMA was less potent at high [Sr2+]o than at low [Sr2+]o. For either the fast or the slow component the PMA‐induced potentiation was accompanied by a reduction in the paired‐pulse ratio (PPR). 5 Despite the different dissociation constant for dextran‐conjugated fura‐2, the fluorescent ratio for intraterminal [Sr2+] ([Sr2+]i) decayed to the baseline after the nerve‐evoked increment with a time course similar to that for [Ca2+]i, suggesting that intraterminal Sr2+ is buffered less efficiently than Ca2+. PMA did not increase the [Sr2+]i transients produced by stimulation of the presynaptic oculomotor nerve. 6 It is suggested that protein kinase C (PKC) modulates both the fast and slow components through common molecular mechanisms that upregulate the Sr2+ sensitivity of the vesicle fusion probability.
Transendothelial transport of renin–angiotensin system components

Background Vascular (interstitial) angiotensin (ANG) II production depends on circulating renin–angiotensin system (RAS) components. Mannose 6-phosphate (man-6-P) receptors and angiotensin II type 1 (AT1) receptors, via binding and internalization of (pro)renin and ANG II, respectively, could contribute to the transportation of these components across the endothelium. Objective To investigate the mechanism(s) contributing to transendothelial RAS component transport. Methods Human umbilical vein endothelial cells were cultured on transwell polycarbonate filters, and incubated with RAS components in the absence or presence of man-6-P, eprosartan or PD123319, to block man-6-P, AT1 and angiotensin II type 2 (AT2) receptors, respectively. Results Apically applied (pro)renin and angiotensinogen slowly entered the basolateral compartment, in a similar manner as horseradish peroxidase, a molecule of comparable size that reaches the interstitium via diffusion only. Prorenin transport was unaffected by man-6-P. Apical ANG I and ANG II rapidly reached the basolateral fluid independent of AT1 and AT2 receptors. Basolateral ANG II during apical ANG I application was as high as apical ANG II, whereas during apical ANG II application it was lower. During basolateral ANG I application, ANG II generation occurred basolaterally only, in an angiotensin-converting enzyme (ACE)-dependent manner. Conclusions Circulating (pro)renin, angiotensinogen, ANG I and ANG II enter the interstitium via diffusion, and interstitial ANG II generation is mediated, at least in part, by basolaterally located endothelial ACE.
A Novel Anti-Inflammatory Effect for High Density Lipoprotein

High density lipoprotein has anti-inflammatory effects in addition to mediating reverse cholesterol transport. While many of the chronic anti-inflammatory effects of high density lipoprotein (HDL) are attributed to changes in cell adhesion molecules, little is known about acute signal transduction events elicited by HDL in endothelial cells. We now show that high density lipoprotein decreases endothelial cell exocytosis, the first step in leukocyte trafficking. ApoA-I, a major apolipoprotein of HDL, mediates inhibition of endothelial cell exocytosis by interacting with endothelial scavenger receptor-BI which triggers an intracellular protective signaling cascade involving protein kinase C (PKC). Other apolipoproteins within the HDL particle have only modest effects upon endothelial exocytosis. Using a human primary culture of endothelial cells and murine apo-AI knockout mice, we show that apo-AI prevents endothelial cell exocytosis which limits leukocyte recruitment. These data suggest that high density lipoprotein may inhibit diseases associated with vascular inflammation in part by blocking endothelial exocytosis.
Evolution of cardiorespiratory interactions with age

We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16–90. By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure. By treating the heart and respiration as coupled oscillators, we then apply a method based on Bayesian inference to find the underlying coupling parameters and their time dependence, deriving from them measures such as synchronization, coupling directionality and the relative contributions of different mechanisms. We report a detailed analysis of the reconstructed cardiorespiratory coupling function, its time evolution and age dependence. We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.
β3A-adaptin, a Subunit of the Adaptor-like Complex AP-3*

Recent studies have described a widely expressed adaptor-like complex, named AP-3, which is likely involved in protein sorting in exocytic/endocytic pathways. The AP-3 complex is composed of four distinct subunits. Here, we report the identification of one of the subunits of this complex, which we call β3A-adaptin. The predicted amino acid sequence of β3A-adaptin reveals that the protein is closely related to the neuron-specific protein β-NAP (61% overall identity) and more distantly related to the β1- and β2-adaptin subunits of the clathrin-associated adaptor complexes AP-1 and AP-2, respectively. Sequence comparisons also suggest that β3A-adaptin has a domain organization similar to β-NAP and to β1- and β2-adaptins. β3A-adaptin is expressed in all tissues and cells examined. Co-purification and co-precipitation analyses demonstrate that β3A-adaptin corresponds to the ∼140-kDa subunit of the ubiquitous AP-3 complex, the other subunits being δ-adaptin, p47A (now called μ3A) and ς3 (A or B). β3A-adaptin is phosphorylated on serine residues in vivo while the other subunits of the complex are not detectably phosphorylated. β3A-adaptin is not present in significant amounts in clathrin-coated vesicles. The characteristics of β3A-adaptin reported here lend support to the idea that AP-3 is a structural and functional homolog of the clathrin-associated adaptors AP-1 and AP-2.
Challenges for the application of optical stimulation in the cochlea for the study and treatment of hearing loss

ABSTRACT Introduction: Electrical stimulation has long been the most effective strategy for evoking neural activity from bionic devices and has been used with great success in the cochlear implant to allow deaf people to hear speech and sound. Despite its success, the spread of electrical current stimulates a broad region of neural tissue meaning that contemporary devices have limited precision. Optical stimulation as an alternative has attracted much recent interest for its capacity to provide highly focused stimuli, and therefore, potentially improved sensory perception. Given its specificity of activation, optical stimulation may also provide a useful tool in the study of fundamental neuroanatomy and neurophysiological processes. Areas covered: This review examines the advances in optical stimulation – infrared, nanoparticle-enhanced, and optogenetic-based – and its application in the inner ear for the restoration of auditory function following hearing loss. Expert opinion: Initial outcomes suggest that optogenetic-based approaches hold the greatest potential and viability amongst optical techniques for application in the cochlea. The future success of this approach will be governed by advances in the targeted delivery of opsins to auditory neurons, improvements in channel kinetics, development of optical arrays, and innovation of opsins that activate within the optimal near-infrared therapeutic window.