Miracle-dz/UniFAR-FTUs huggingface dataset:
An architecturally constrained model of random number generation and its application to modeling the effect of generation rate

Random number generation (RNG) is a complex cognitive task for human subjects, requiring deliberative control to avoid production of habitual, stereotyped sequences. Under various manipulations (e.g., speeded responding, transcranial magnetic stimulation, or neurological damage) the performance of human subjects deteriorates, as reflected in a number of qualitatively distinct, dissociable biases. For example, the intrusion of stereotyped behavior (e.g., counting) increases at faster rates of generation. Theoretical accounts of the task postulate that it requires the integrated operation of multiple, computationally heterogeneous cognitive control (“executive”) processes. We present a computational model of RNG, within the framework of a novel, neuropsychologically-inspired cognitive architecture, ESPro. Manipulating the rate of sequence generation in the model reproduced a number of key effects observed in empirical studies, including increasing sequence stereotypy at faster rates. Within the model, this was due to time limitations on the interaction of supervisory control processes, namely, task setting, proposal of responses, monitoring, and response inhibition. The model thus supports the fractionation of executive function into multiple, computationally heterogeneous processes.
Huanglongbing, a Systemic Disease, Restructures the Bacterial Community Associated with Citrus Roots

ABSTRACT To examine the effect of pathogens on the diversity and structure of plant-associated bacterial communities, we carried out a molecular analysis using citrus and huanglongbing as a host-disease model. 16S rRNA gene clone library analysis of citrus roots revealed shifts in microbial diversity in response to pathogen infection. The clone library of the uninfected root samples has a majority of phylotypes showing similarity to well-known plant growth-promoting bacteria, including Caulobacter, Burkholderia, Lysobacter, Pantoea, Pseudomonas, Stenotrophomonas, Bacillus, and Paenibacillus. Infection by “Candidatus Liberibacter asiaticus” restructured the native microbial community associated with citrus roots and led to the loss of detection of most phylotypes while promoting the growth of bacteria such as Methylobacterium and Sphingobacterium. In pairwise comparisons, the clone library from uninfected roots contained significantly higher 16S rRNA gene diversity, as reflected in the higher Chao 1 richness estimation (P ≤ 0.01) of 237.13 versus 42.14 for the uninfected and infected clone libraries, respectively. Similarly, the Shannon index of the uninfected clone library (4.46) was significantly higher than that of the infected clone library (2.61). Comparison of the uninfected clone library with the infected clone library using LIBSHUFF statistics showed a significant difference (P ≤ 0.05). Quantitative PCR analysis revealed that the bacterial community changes not only qualitatively but also quantitatively. The relative proportions of different groups of bacteria changed significantly after infection with the pathogen. These data indicate that infection of citrus by “Ca. Liberibacter asiaticus” has a profound effect on the structure and composition of the bacterial community associated with citrus roots.
Faecal carriage of verocytotoxin-producing Escherichia coli 0157 in cattle and sheep at slaughter in Great Britain

A 12-month abattoir survey was conducted between January 1999 and January 2000, to determine the prevalence of faecal carriage of verocytotoxin-producing Escherichia coli 0157 (VTEC 0157) in cattle and sheep slaughtered for human consumption in Great Britain. Samples of rectum containing faeces were collected from 3939 cattle and 4171 sheep at 118 abattoirs, in numbers proportional to the throughput of the premises. The annual prevalence of faecal carriage of VTEC 0157 was 4.7 per cent (95 per cent confidence interval 4.1 to 5.4) for cattle and 1.7 per cent (1.3 to 2.1) for sheep, values which were statistically significantly different from each other (P<0.001). The organisms were recovered from both cattle and sheep slaughtered throughout the year and at abattoirs in all regions of the country, but the highest prevalence was in the summer. The most frequency recovered VTEC 0157 isolates were phage types 2, 8 and 21/28 in cattle and 4 and 32 in sheep, the five most frequently isolated phage types associated with illness in people in Great Britain during the same period.
The Double-Peak Spectral Energy Density of Gamma-Ray Bursts and the True Identity of GRB 031203

A double-peak spectral energy density of prompt γ-rays, similar to that observed in blazars, is expected in the cannonball (CB) model of gamma-ray bursts (GRBs) produced in supernova (SN) explosions. The first sub-MeV ordinary peak is formed by inverse Compton scattering (ICS) of the ambient SN light by the CBs' electrons, while the second peak at GeV-TeV energies is formed by ICS of interstellar medium electrons accelerated by the jetted CBs from the SN explosion. Usually the second peak is in the GeV-TeV range. However, in X-ray flashes with a low peak energy, which in the CB model are normal GRBs viewed far off-axis, the second peak energy moves to the MeV range. In far off-axis GRBs, such as 980425 and 031203, the second peak may have been confused with the normal GRB peak. In most GRBs that have been observed so far, the γ-ray detectors ran out of statistics far below the second peak. However, in bright GRBs, the two peaks may be resolved by simultaneous measurements with Swift, INTEGRAL, and GLAST.
Are We Over Oxidized? Oxidative Stress, Cardiovascular Disease, and the Future of Intervention Studies with Antioxidants

A number of recent clinical trials with antioxidants, notably vitamin C and E, have provided no support for the commonly held view that increasing our intake of antioxidants will offset the ravages of cardiovascular disease as well as other diseases (for extensive critical reviews see: Kritharides and Stocker 2002; Antoniades et al 2003; Touyz 2004). Is this conclusion justified? The role of antioxidant dietary adjuncts and therapy in prevention and treatment remains a highly important clinical question. In this opinion article we address the question: Is there a future for antioxidant therapy in the treatment and prevention of cardiovascular disease? We conclude that there is a need for better-designed studies as well as a re-thinking of the choice of antioxidants.
The Path to Exhaustion: Time-Variability Properties of Coordinative Variables during Continuous Exercise

The aim of this study was to detect qualitative changes in the structure of coordinative variable (elbow angle) fluctuations during a quasi-isometric exercise performed until exhaustion. Seven physical education students performed a quasi-isometric arm-curl exercise holding an Olympic bar (weight: 80% 1RM) with an initial elbow flexion of 90° three times over a period of 4 weeks. They were encouraged to persist, even if the elbow angle was lost, until the fatigue-induced spontaneous termination point (FISTP). Changes in both elbow angles were registered during the task through an electrogoniometer. Detrended Fluctuation Analysis (DFA) was conducted on the initial and final 1024 data points of the series and the associated Hurst exponents were obtained. Multi-way RM ANOVA analyses revealed a significant main effect of the Time on task on the Hurst exponent values but also revealed a significant Trial × Time on task interaction. In the initial (non-fatigue) condition participants tended to produce anti-persistent fBm fluctuations. In the final part before exhaustion a tendency toward persistent fBm was dominant. The trial to trial differences in time-variability structure points to an existence of a long-term variability in control strategies during exercise. The changes in the temporal structure of the elbow angle variability as effort accumulated reflected an increase in low-frequency fluctuations signifying a change in psychobiological mechanisms used to negotiate the task demands. The variability properties of the coordinative variable during exercise may provide information about the dynamic mechanisms that lead to exhaustion.
Toward determining best items for identifying therapeutic problem areas

Toward Determining Best Items for Identifying Therapeutic Problem Areas Kevin L. Kimball Department of Psychology Doctor of Philosophy While most clients show improvement in therapy, anomalously, 5% to 10% actually worsen, and a significant minority of clients shows little or no response to therapy. Earlier studies developed clinical support tools (CSTs) designed to provide feedback to therapists about potential problem areas and to improve the likelihood of a positive outcome for clients identified as at-risk for a negative outcome in therapy (Harmon et. al. 2007; Slade, Lambert, Harmon, Smart, & Bailey, 2008; Whipple et al., 2003). While varying from study to study, the CSTs looked at five domains: therapeutic alliance, motivation to change, social support, life events, and perfectionism. More than 100 questions were used to assess these domains. The major goal of this study was to streamline the CST measures to increase efficiency. Toward that end, a new instrument consisting of 37 questions was developed by administering questionnaires to 169 patients at a rural Utah mental health center. In addition, the life events and social support questions were given to 76 students at Brigham Young University and 88 randomly selected residents of Utah County. Using item response analysis and mean scores for each dimension, subscale cut scores were developed for four dimensions: therapeutic alliance, motivation for therapy, social support, and life events. The perfectionism subscale was dropped from the questionnaire because perfectionism was deemed to be too stable to be useful for the intended use of the measure. Cut scores were also developed for each individual question. These subscale and individual item cut scores are intended to help clinicians identify potential problem areas to be explored during the course of therapy.
Periodontitis is associated with preeclampsia in pregnant women.

BACKGROUND Recent investigations have demonstrated a positive association between periodontitis and pregnancy complications. The purpose of this study was to determine the effect of periodontitis and the subgingival microbial composition on preeclampsia. METHODS A case-control study was carried out in Cali, Colombia that included 130 preeclamptic and 243 non-preeclamptic women between 26 to 36 weeks of pregnancy. Sociodemographic data, obstetric risk factors, periodontal status, and subgingival microbial composition were determined in both groups. Preeclampsia was defined as blood pressure>or=140/90 mm Hg, and >or=2+ proteinuria, confirmed by 0.3 g proteinuria/24 hours of urine specimens. Controls were healthy pregnant women. Odds ratios (ORs) for periodontitis and subgingival microbiota compositions were calculated. RESULTS A total of 83 out of 130 preeclamptic women (63.8%) and 89 out of 243 controls (36.6%) had chronic periodontitis (OR: 3.0; 95% confidence interval (CI): 1.91 to 4.87; P<0.001). Clinical attachment loss increased in the case group (4.0+/-0.10 mm) compared to the control group (3.0+/-0.08 mm) (P<0.001). The average newborn birth weight from preeclamptic mothers was 2.453 g, whereas in controls was 2.981 g (P<0.001). Two red complex microorganisms, Porphyromonas gingivalis and Tannerella forsythensis, and the green complex microorganism Eikenella corrodens were more prevalent in the preeclamptic group than in controls (P<0.01). CONCLUSIONS Chronic periodontal disease and the presence of P. gingivalis, T. forsythensis, and E. corrodens were significantly associated with preeclampsia in pregnant women. Further research is needed to establish pathogenic mechanisms of active periodontal disease and subgingival periodontopathogens related to preeclampsia development.
Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study

Background: We investigated the demographic, clinical, and neuropsychological characteristics of frontotemporal dementia (FTD) from the Clinical Research Center for Dementia of South Korea (CREDOS)-FTD registry. Methods: A total of 200 consecutive patients with FTD recruited from 16 neurological clinics in Korea were evaluated by cognitive and functional assessments, a screening test for aphasia, behavioral questionnaires, motor assessments, and brain MRI or PET. Results: In our registry, 78 patients were classified as having been diagnosed with behavioral-variant FTD (bvFTD), 70 with semantic dementia (SD), 33 with progressive nonfluent aphasia (PNFA), and 8 with motor neuron disease plus syndrome (MND-plus). The patients with language variants of dementia were older than those with bvFTD. There were no differences in sex ratio, duration of illness, or level of education among the four subgroups. Overall, the patients with bvFTD showed a significantly better performance in cognitive tests. A higher frequency of motor symptoms and a lower frequency of behavioral symptoms were found in PNFA than in bvFTD and SD. The Global Language Index was significantly lower in SD than in bvFTD and PNFA. The MND-plus group had a poorer performance than all the others in all cognitive domains. Conclusion: The neuropsychological, behavioral, motor, and language characteristics of the four subtypes are comparable with those from other series. However, the proportion of SD (37.0%), which was similar to that of bvFTD (41.3%), was higher in our registry than in other series.
On the parameter estimation of linear models of aggregate power system loads

This paper addressed some theoretical and practical issues relevant to the problem of power system load modeling and identification. An identification method is developed in the theoretical framework of stochastic system identification. The identification method presented in this paper belongs to the family of output error models and is based on well-established equations describing load recovery mechanisms having a commonly recognized physical appeal. Numerical experiments with artificially created data are first performed on the proposed technique and the estimates obtained proved to be reliable and accurate. The proposed method is then tested using actual field measurements taken at a paper mill, and the corresponding results are used to validate a commonly used linear model of aggregate power system load. The results reported in this paper indicate that the existing load models satisfactorily describe the actual behavior of the physical load and can be reliably estimated using the identification techniques presented herein.
Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells

Background Humanized mice able to reconstitute a surrogate human immune system (HIS) can be used for studies on human immunology and may provide a predictive preclinical model for human vaccines prior to clinical trials. However, current humanized mouse models show sub-optimal human T cell reconstitution and limited ability to support immunoglobulin class switching by human B cells. This limitation has been attributed to the lack of expression of Human Leukocyte Antigens (HLA) molecules in mouse lymphoid organs. Recently, humanized mice expressing HLA class I molecules have been generated but showed little improvement in human T cell reconstitution and function of T and B cells. Methods We have generated NOD.Rag1KO.IL2RγcKO mice expressing HLA class II (HLA-DR4) molecules under the I-Ed promoter that were infused as adults with HLA-DR-matched human hematopoietic stem cells (HSC). Littermates lacking expression of HLA-DR4 molecules were used as control. Results HSC-infused HLA-DR4.NOD.Rag1KO.IL-2RγcKO mice developed a very high reconstitution rate (>90%) with long-lived and functional human T and B cells. Unlike previous humanized mouse models reported in the literature and our control mice, the HLA-DR4 expressing mice reconstituted serum levels (natural antibodies) of human IgM, IgG (all four subclasses), IgA, and IgE comparable to humans, and elicited high titers of specific human IgG antibodies upon tetanus toxoid vaccination. Conclusions Our study demonstrates the critical role of HLA class II molecules for development of functional human T cells able to support immunoglobulin class switching and efficiently respond to vaccination.
Reducing forwarding state in content-centric networks with semi-stateless forwarding

Routers in the Content-Centric Networking (CCN) architecture maintain state for all pending content requests, so as to be able to later return the corresponding content. By employing stateful forwarding, CCN supports native multicast, enhances security and enables adaptive forwarding, at the cost of excessive forwarding state that raises scalability concerns. We propose a semi-stateless forwarding scheme in which, instead of tracking each request at every on-path router, requests are tracked at every d hops. At intermediate hops, requests gather reverse path information, which is later used to deliver responses between routers using Bloom filter-based stateless forwarding. Our approach effectively reduces forwarding state, while preserving the advantages of CCN forwarding. Evaluation results over realistic ISP topologies show that our approach reduces forwarding state by 54%-70% in unicast delivery, without any bandwidth penalties, while in multicast delivery it reduces forwarding state by 34%-55% at the expense of 6%-13% in bandwidth overhead.
Chemotherapy improves low performance status lung cancer patients

The aim of the present study was to determine the potential benefit of conventional cisplatin-based chemotherapy on patients with advanced nonsmall cell lung cancer (NSCLC) and poor performance status (PS), defined as 60–70 on the Karnofsky scale. Retrospective analysis was carried out of a randomised trial performed in advanced NSCLC where 485 patients received three courses of gemcitabine+ifosfamide+cisplatin induction chemotherapy. Of the patients, 80% had good PS (Karnofsky 80–100) and 20% poor PS. Response rates were 38 and 28%, respectively. Clinical improvement, defined as achieving a good PS during chemotherapy, was observed overall in 25% of the poor PS patients, with rates of 38, 20 and 14%, respectively, in case of response, no change and progression. PS improved more quickly in the responders. Survival of patients with poor PS was significantly worse, but survival of responders was similar, irrespective of the initial poor or good PS. Although nonfatal toxicity was almost similar, there were more toxic deaths (including vascular and cardiac fatalities) in the poor PS patients (9.2 versus 2.1%). In conclusion, combination chemotherapy is associated with clinical improvement in a substantial number of patients with advanced nonsmall cell lung cancer of poor performance status.
Real-time decompression and visualization of animated volume data

Interactive exploration of animated volume data is required by many application, but the huge amount of computational time and storage space needed for rendering does not yet allow the visualization of animated volumes. In this paper, we introduce an algorithm running at interactive frame rates using 3D wavelet transforms that allows for any wavelet, motion compensation techniques and various encoding schemes of the resulting wavelet coefficients to be used. We analyze different families and orders of wavelets for compression ratio and the introduced error. We use a quantization that has been optimized for the visual impression of the reconstructed volume, independent of the viewing algorithm. This enables us to achieve very high compression ratios while still being able to reconstruct the volume with as few visual artifacts as possible. A further improvement of the compression ratio has been achieved by applying a motion compensation scheme to exploit temporal coherency. Using these schemes, we are able to decompress each volume of our animation at interactive frame rates, while visualizing these decompressed volumes on a single PC. We also present a number of improved visualization algorithms for high-quality display using OpenGL hardware running at interactive frame rates on a standard PC.
Gamma knife radiosurgery in the management of cavernous sinus meningiomas.

OBJECT The authors sought to assess the functional tolerance and tumor control rate of cavernous sinus meningiomas treated by gamma knife radiosurgery (GKS). METHODS Between July 1992 and October 1998, 92 patients harboring benign cavernous sinus meningiomas underwent GKS. The present study is concerned with the first 80 consecutive patients (63 women and 17 men). Gamma knife radiosurgery was performed as an alternative to surgical removal in 50 cases and as an adjuvant to microsurgery in 30 cases. The mean patient age was 49 years (range 6-71 years). The mean tumor volume was 5.8 cm3 (range 0.9-18.6 cm3). On magnetic resonance (MR) imaging the tumor was confined in 66 cases and extensive in 14 cases. The mean prescription dose was 28 Gy (range 12-50 Gy), delivered with an average of eight isocenters (range two-18). The median peripheral isodose was 50% (range 30-70%). Patients were evaluated at 6 months, and at 1, 2, 3, 5, and 7 years after GKS. The median follow-up period was 30.5 months (range 12-79 months). Tumor stabilization after GKS was noted in 51 patients, tumor shrinkage in 25 patients, and enlargement in four patients requiring surgical removal in two cases. The 5-year actuarial progression-free survival was 92.8%. No new oculomotor deficit was observed. Among the 54 patients with oculomotor nerve deficits, 15 improved, eight recovered, and one worsened. Among the 13 patients with trigeminal neuralgia, one worsened (contemporary of tumor growing), five remained unchanged, four improved, and three recovered. In a patient with a remnant surrounding the optic nerve and preoperative low vision (3/10) the decision was to treat the lesion and deliberately sacrifice the residual visual acuity. Only one transient unexpected optic neuropathy has been observed. One case of delayed intracavernous carotid artery occlusion occurred 3 months after GKS, without permanent deficit. Another patient presented with partial complex seizures 18 months after GKS. All cases of tumor growth and neurological deficits observed after GKS occurred before the use of GammaPlan. Since the initiation of systematic use of stereotactic MR imaging and computer-assisted modern dose planning, no more side effects or cases of tumor growth have occurred. CONCLUSIONS Gamma knife radiosurgery was found to be an effective low morbidity-related tool for the treatment of cavernous sinus meningioma. In a significant number of patients, oculomotor functional restoration was observed. The treatment appears to be an alternative to surgical removal of confined enclosed cavernous sinus meningioma and should be proposed as an adjuvant to surgery in case of extensive meningiomas.
Enhancing User eXperience during waiting time in HCI: contributions of cognitive psychology

Despite technological progress, daily Human-Computer Interactions (HCI) are still encompassing moments where the interaction between the user and the system is temporarily interrupted (file download, setup of a program, etc.). These waiting times are often sources of anxiety and irritation. In order to enhance the User eXperience (UX) during waiting time in HCI, this research based on cognitive models of time perception focuses on the impact of several variables on the satisfaction and waiting time perceived by a user. Variations in waiting time duration, cognitive workload and informational level of a feedback screen are therefore experimentally created to study their impact on satisfaction and waiting time perception. The results confirm the existence of a link between cognitive workload and waiting time perception and may provide valuable information for User Interface design.