Miracle-dz/UniFAR-FTUs huggingface dataset:
The Rise and Fall of Foreign Exchange Market Intervention

The premise of the paper is that the fervor for foreign exchange market intervention by U.S, and European monetary authorities has ebbed in recent years. A pattern of initial belief in the effectiveness of foreign exchange market intervention has recently been eroded, as is revealed by the absence of intervention in circumstances that in earlier times would have invoked it. Only the Bank of Japan among central banks of the developed world has not thusfar abandoned its faith that intervention can change the relative value of the yen as determined by market forces to conform with its notion of what that value should be. To explain why U.S. and European monetary authorities no longer believe that intervention is a tool that works, I review the equivocal record of past episodes, the inconclusive results of empirical research, and the problems of implementation that intervention advocates ignore.
Dental utilization by low-income mothers.

OBJECTIVE This study examines the influence of predisposing, enabling, and need variables on whether low-income mothers sought dental care during the past year. This report is a substudy of mothers and children on their self-reported health status, utilization, access, and satisfaction with health care in general. METHODS A convenience sample of 502 mothers and youngest child younger than 6 years old was administered a face-to-face questionnaire in four Ohio counties. Information was collected at county human services offices and WIC clinics between November 1995 and July 1996. Using whether or not the mother sought dental care as the dependent variable, logistic regression models were created for the variables within the predisposing, enabling, and need characteristics separately and together. RESULTS Fewer than one-half of the mothers sought dental care during the past year. Variables associated with the predisposing characteristic explained little about who sought care. Those mothers who have Medicaid coverage are 2.7 times more likely to have a dental visit than those without insurance. Moreover, those mothers who perceive any dental need are several times less likely to have received dental care than those who have no perceived need. CONCLUSIONS Even among a somewhat homogeneous population of low-income women, source of payment for dental services and perceived need for dental care are discriminating variables in determining who seeks dental care.
A piece in the puzzle of intrauterine fetal death: Pathological findings in placentas from term and preterm intrauterine fetal death pregnancies

Objective. To compare pathological findings of placentas from term and preterm pregnancies complicated by intrauterine fetal death (IUFD). Study design. A retrospective cohort study was conducted including deliveries complicated by IUFD. A comparison was made between placentas from term and preterm (<37 weeks' gestation) pregnancies complicated by IUFD. A second analysis was undertaken comparing IUFD placentas delivered before and after 34 weeks' gestation. Uteroplacental insufficiency was defined when one or more of the following pathological features were found: placental infarct, poor vascularity of the chorionic villi, intravascular thrombi and vascular occlusion. Results. During the study period, 849 placentas of IUFD were examined. Gross and microscopic pathological finding were noted. When comparing gross and microscopic findings in term and preterm (<37 weeks) IUFD placentas, higher rates of calcifications, tissue congestion and cellular metaplasia were found in term vs. preterm placentas. Significantly increased rates of poor tissue vascularity, placental vascular occlusion and uteroplacental insufficiency were demonstrated in preterm IUFD placentas. When comparing pathological findings in IUFD placentas delivered before and after 34 weeks' gestation, higher rates of abnormal cord insertion, calcifications, tissue congestion, infarcts and intravascular thrombi as well as poor tissue vascularity and placental vascular occlusion were demonstrated in IUFD placentas delivered before 34 weeks. Regardless of gestational age at the time of IUFD in more than 90% of placentas vascular wall thickening was found. A third of both term and preterm placentas demonstrated histological chorioamionitis. Conclusions. A vast majority of IUFD placentas reveal numerous pathological findings that reflect uteroplacental insufficiency and abnormal blood supply. Different characteristics were noted in term and preterm placentas of pregnancies complicated by IUFD. Better definition of causes and associated placental pathological findings of IUFD might aid clinicians in counseling such patients regarding the reason and risk of recurrence in subsequent pregnancies.
Does Money Fly? The Economic Value of Migratory Birdwatching in Xochimilco, Mexico

This paper estimates the economic value that national and international birdwatchers have to keep an urban wetland in this case, Xochimilco (Mexico), as a place of rest, food and/or shelter for migratory birds from North America. For this purpose, it is resorted to surveys and contingent valuation that estimates the willingness to pay (WTP) per year of these watchers. The best estimate indicates that national watchers are willing to pay approximately US $79 per year, while international, US $296. Using these estimates, it is calculated that the economic value of the bird migration environmental service for this urban wetland is located between US $2836 and US $3999 per hectare. This found value can work as an input for decision makers when faced with projects and/or policies that may face different objectives.
Bioremediation of chromium solutions and chromium containing wastewaters

Abstract Cr(VI) represents a serious threat to human health, living resources and ecological system as it is persistent, carcinogenic and toxic, whereas, Cr(III), another stable oxidation state of Cr, is less toxic and can be readily precipitated out of solution. The conventional methods of Cr(VI) removal from wastewaters comprise of chemical reduction followed by chemical precipitation. However, these methods utilize large amounts of chemicals and generate toxic sludge. This necessitates the need for devising an eco-technological strategy that would use the untapped potential of the biological world for remediation of Cr(VI) containing wastewaters. Among several viable approaches, biotransformation of Cr(VI) to relatively non-toxic Cr(III) by chromium resistant bacteria offers an economical- and environment-friendly option for its detoxification. Various studies on use of Cr(VI) tolerant viable bacterial isolates for treatment of Cr(VI) containing solutions and wastewater have been reported. Therefore, a detailed account of mechanisms and processes involved in bioreduction of Cr(VI) from solutions and wastewaters by bacterial isolates are the focus of this review article in addition to a discussion on toxicity of Cr(VI) on bacterial strains and various factors affecting Cr(VI) bioreduction.
New Estimates of Aboriginal Fertility, 1966-1971 to 1996-2001

Using census data on children in families, this paper estimates various fertility measures for the total aboriginal population and four specific groups, North American Indians, Registered Indians, Metis, and Inuit. The “own-children” procedure is used for deriving the number of births by the age of the mother during specific years preceding the census. The major focus of the paper is on the trends of total fertility rate and the convergence of age patterns between various subgroups over the past 30 years. Strengths and limitations of the method are also discussed.
What Can We Learn About Uncertain Tax Benefits from FIN 48

FIN 48, Accounting for Uncertainty in Income Taxes, standardizes accounting for uncertain tax benefits and requires companies to disclose their tax reserve amounts. We summarize hand-collected disclosures related to tax reserves from 2005 through the first quarter of 2007. For the largest 100 non-financial, non-regulated firms, the reserve at adoption on January 1, 2007 is $78 billion excluding interest, or about two percent of assets. Of this $78 billion, an estimated $58 billion would affect earnings if ever released.
Chemiluminescence enzyme immunoassay for monitoring hepatitis C virus core protein during interferon‐α2b and ribavirin therapy in patients with genotype 1 and high viral loads

This study evaluated an updated chemiluminescence enzyme immunoassay (CLEIA) for hepatitis C virus (HCV) core protein for monitoring viral kinetics during treatment with interferon (IFN)‐α and ribavirin. Using the CLEIA, serum levels of HCV core protein were measured in 17 patients with genotype 1 and high baseline viral loads during the first 4 weeks of combination therapy. HCV RNA was measured by the Amplicor Monitor test for comparison. At the start of therapy, the median HCV level (interquartile range) was 700 (540–940) kIU/ml of viral RNA and 11,310 (5,528–14,238) fmol/L of core protein. HCV RNA was above the upper limit of the linear range of the Amplicor Monitor test in 13 of the 17 patients, while the core protein level was within the linear range of the CLEIA in all patients. During therapy, the proportion of patients with HCV levels below the cutoff values at each time point was less with the Amplicor Monitor test than with CLEIA. Serum HCV core protein level decreased rapidly during the first 24 hr of therapy and more slowly thereafter, with median exponential decays of 1.08 and 0.046 log10/day, respectively. In the second phase, between day 1 and 28, the median decrease in HCV core protein level was higher in four patients with sustained virologic response (0.13 log10/day) than in 13 patients with no response (0.028 log10/day, P = 0.042). The wide linear range of the HCV core protein assay is appropriate for measuring viral loads during therapy with IFN‐α and ribavirin. J. Med. Virol. 77:77–82, 2005. © 2005 Wiley‐Liss, Inc.
Budget Deficits, Domestic Investment, And Trade Deficits

This paper summarizes recent empirical studies on the effects of budget deficits on interest rates, investment, and trade deficits in the United States. It also reports new evidence on the effects of budget deficits on investment and on trade deficits for the 1980s. The results support the view that budget deficits crowd out domestic investment and increase trade deficits. Copyright 1993 Western Economic Association International.
In Vivo Confocal Microscopy of Combined Pre-Descemet Membrane Corneal Dystrophy and Fuchs Endothelial Dystrophy

Purpose: To report the in vivo confocal microscopy (CM) findings of a patient with combined pre-Descemet membrane corneal dystrophy and Fuchs endothelial dystrophy. Methods: A 38-year-old woman with pre-Descemet membrane corneal dystrophy and Fuchs endothelial dystrophy was studied. Routine ophthalmic examination, standard slit-lamp biomicroscopy, pachymetry, and in vivo CM analysis of the morphology of the corneal epithelium, subbasal nerves, stroma, and endothelium were performed. Results: Biomicroscopy revealed bilateral corneal guttae with central corneal edema, beaten metal appearance, and pigment dusting of the endothelium. Numerous tiny pleomorphic opacities located in the deep stroma immediately anterior to Descemet membrane were evidenced in both eyes. In vivo CM showed numerous pleomorphic and highly reflective small particles in the cytoplasm of keratocytes in the deep stroma adjacent to the corneal endothelial layer. No abnormalities could be detected in the epithelial layer and in the midstromal layer. In the endothelial layer, there were multifocal hyporeflective areas with occasional central highlight among hyperreflective endothelial cells. The ultrasonic pachymetry showed corneal thicknesses of 652 and 628 μm in the right eye and in the left eye, respectively. Conclusions: In vivo CM is a powerful tool in the study of rare corneal dystrophies and degenerations and nonprogressive or slowly progressive corneal disorders where there is a limited availability of corneal tissue for examination and when the final diagnosis is difficult to obtain with conventional methods.
Snurportin1, an m3G‐cap‐specific nuclear import receptor with a novel domain structure

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal (NLS). The latter is composed of the 5′‐2,2,7‐terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. Here, we describe the isolation and cDNA cloning of a 45 kDa protein, termed snurportin1, which interacts specifically with m3G‐cap but not m7G‐cap structures. Snurportin1 enhances the m3G‐capdependent nuclear import of U snRNPs in both Xenopus laevis oocytes and digitonin‐permeabilized HeLa cells, demonstrating that it functions as an snRNP‐specific nuclear import receptor. Interestingly, solely the m3G‐cap and not the Sm core NLS appears to be recognized by snurportin1, indicating that at least two distinct import receptors interact with the complex snRNP NLS. Snurportin1 represents a novel nuclear import receptor which contains an N‐terminal importin β binding (IBB) domain, essential for function, and a C‐terminal m3G‐cap‐binding region with no structural similarity to the arm repeat domain of importin α.
The feasibility of surgical salvage of thrombosed arteriovenous fistula by an interventional nephrologist

Background Salvage of a thrombosed arteriovenous fistula (AVF) by secondary fistula conversion may be more effective than a conventional endovascular procedure for forearm fistula thrombosis. Surgical access procedures are an undeveloped area in interventional nephrology compared to endovascular procedures. Herein, the author report the results of surgical salvage of thrombosed AVFs by interventional nephrologists. Methods The author retrospectively analyzed 52 surgical salvage procedures for AVF thrombosis (radiocephalic fistula = 44 cases, brachiocephalic fistula = 8 cases) that were performed by interventional nephrologist between March 2007 and January 2016. Results Secondary fistula formation using the proximal vein was performed for 46 cases (88.5%); outflow rerouting was performed for two cephalic-arch stenosis cases (3.9%), simple thrombectomy was performed for two cases (3.9%), and a graft interposition was performed for two cases (3.9%). Technical success after the surgical procedures was achieved in 51 cases (98.1%), and 39 AVFs (75.0%) were prepared for immediate puncturing without catheter insertion. The primary and secondary patency rates for AVF at 6, 12, 18, and 24 months were 88.5%, 83.2%, 83.2%, and 83.2% and 96.0%, 96.0%, 93.2%, and 93.2%, respectively. The re-intervention rate was 0.27 ± 0.92/patient/ year. Conclusion Based on these results, the author conclude that surgical salvage of a thrombosed AVF, when performed under local anesthesia by a skilled interventional nephrologist, offers favorable short- and long-term success and should be the preferred treatment.
Can neuromuscular strength and function in people with dementia be rehabilitated using resistance-exercise training? Results from a preliminary intervention study.

BACKGROUND Neuromuscular weakness is a prominent symptom among people with central nervous system disorders, such as dementia, typically leading to disability in activities of daily life. We sought to evaluate the potential of resistance exercise to improve neuromuscular strength and function in the lower extremities among community-dwelling people with dementia. METHODS Twenty-eight subjects, aged 70-88 years and with an average Mini-Mental State Examination score of 17.8 +/- 7.2, were recruited from a population of adult daycare facility users. Subjects underwent pre- and postintervention assessment of strength and physical function consisting of determination of bilateral maximum strength of the knee extensor, hip flexor, dorsiflexor muscles, and handgrip; and evaluation of lower-extremity function based on repeated chair stands and gait speed. The intervention consisted of moderate-intensity progressive resistance training of the hip extensors, abductors, knee extensors and flexors, and dorsiflexors using the Theraband resistance system for up to 3 days weekly over a 6-week period. RESULTS Subjects completed an average of 11.4 +/- 2.5 exercise sessions. Among those who exercised at least twice per week (> or = 12), they improved an average of 15.6% in quadriceps strength, 10.1% in handgrip strength, 22.2% in sit-to-stand (STS) time, 9.9% in usual gait time, 5.4% in fast gait time (p =.03), and 14.0% in the timed-up-and-go (TUG) test. CONCLUSIONS Subjects demonstrated improvements in some areas of muscular capacity (quadriceps and handgrip) and most tests of lower-extremity function (STS, gait, TUG), yet declines in other areas (dorsiflexion and iliopsoas strength). Although strength or functional deficits in all domains were not remediable, these results suggest the potential of a resistance-exercise intervention of longer duration and/or greater intensity to produce beneficial effects on the neuromuscular functioning of people with dementia.
Governance in EU foreign policy: exploring small state influence

It is often stated that small states are not left much choice other than to accept the authority of large states in European Union (EU) foreign policy. This article argues that they may indeed be small in terms of resources but not necessarily in terms of influence. Conceptualizing EU foreign policy as a system of governance, the article suggests a framework for analysis to explain the extent to which small states may wield influence. The utility of the proposed framework is demonstrated by examining Belgian diplomatic activity in EU foreign policy towards the Democratic Republic of the Congo.
ECONOMIC FEASIBILITY OF COMMUNITY-BASED FISH CULTURE IN SEASONALLY FLOODED RICE FIELDS IN BANGLADESH AND VIETNAM

ABSTRACT During the rainy season in extensive river floodplains and deltaic lowlands, floods lasting several months render the land unavailable for crop production for several months each year. These waters are considerably underutilized in terms of managed aquatic productivity. This raises the opportunity to enclose parts of these annually occurring floodwater areas to produce a crop of specifically stocked aquatic organisms aside from the naturally occurring ‘wild’ species that are traditionally fished and are not affected by the culture activity, overall resulting in more high-quality, nutrient-dense food production and enhanced farm income for all stakeholders, notably the poor. The WorldFish Center and its national partners recently tested two systems in a community based management approach in Bangladesh and Vietnam: (i) concurrent rice-fish culture in shallower flooded areas, and (ii) alternating rice and fish culture in the deep-flooded areas. Results indicate that community-based fish culture in rice fields is technically feasible, economically viable and socially acceptable. It can increase fish production to about 600 kg/ha/year in shallow flooded areas and up to 1.5 t/ha/year in deep-flooded areas, without reduction in rice yield and wild fish catch. For the overall system and in the trials conducted, an additional income of US$135 per ha in southern Vietnam, and up to US$437 per ha in Bangladesh were achieved, which is an increase of 20%to 85% over the previous profitability. The communities neighboring the trial sites have been adopting the technologies widely.
High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation

IgM is the first antibody produced during the humoral immune response. Despite its fundamental role in the immune system, IgM is structurally only poorly described. In this work we used X-ray crystallography and NMR spectroscopy to determine the atomic structures of the constant IgM Fc domains (Cµ2, Cµ3, and Cµ4) and to address their roles in IgM oligomerization. Although the isolated domains share the typical Ig fold, they differ substantially in dimerization properties and quaternary contacts. Unexpectedly, the Cµ4 domain and its C-terminal tail piece are responsible and sufficient for the specific polymerization of Cµ4 dimers into covalently linked hexamers of dimers. Based on small angle X-ray scattering data, we present a model of the ring-shaped Cµ4 structure, which reveals the principles of IgM oligomerization.
Volunteer tourism and beyond: motivations and barriers to participation in protected area enhancement

After reviewing volunteer tourist motivations generally, 804 domestic visitors to two National Parks in Australia's Gold Coast region were surveyed to identify the motivations and barriers that would either facilitate or inhibit participation in a range of 20 hypothetical volunteering and “quasi-volunteering” site enhancement activities, both on- and off-site, that could help achieve park/visitor symbiosis. Factor analysis of 24 motivation items from the valid returned questionnaires revealed “altruism”, “personal wellbeing” and “personal status” dimensions, with only the first two attracting overall positive means. Variable support for these site enhancement activities, however, was evident when motivation means and factor scores were calculated for visitor segments identified earlier. Clusters open to participation yielded higher motivation levels, but the “altruism” dimension showed a greater range from higher to lower willingness. Throughout, the motivation scores of females were higher. Distance and time were the main barriers to participation, with low amenability clusters yielding the highest level of perceived barriers. The results suggest that motivations of altruism and selected self-interest should be combined in strategies to attract and satisfy participants in protected area site enhancement, to develop aspects of the ecotourium concept and capitalise on the growing interest in personal wellbeing.
Genetic Evidence for Functional Interaction of the Escherichia coli Signal Recognition Particle Receptor with Acidic Lipids in Vivo*

The mechanism underlying the interaction of the Escherichia coli signal recognition particle receptor FtsY with the cytoplasmic membrane has been studied in detail. Recently, we proposed that FtsY requires functional interaction with inner membrane lipids at a late stage of the signal recognition particle pathway. In addition, an essential lipid-binding α-helix was identified in FtsY of various origins. Theoretical considerations and in vitro studies have suggested that it interacts with acidic lipids, but this notion is not yet fully supported by in vivo experimental evidence. Here, we present an unbiased genetic clue, obtained by serendipity, supporting the involvement of acidic lipids. Utilizing a dominant negative mutant of FtsY (termed NG), which is defective in its functional interaction with lipids, we screened for E. coli genes that suppress the negative dominant phenotype. In addition to several unrelated phenotype-suppressor genes, we identified pgsA, which encodes the enzyme phosphatidylglycerophosphate synthase (PgsA). PgsA is an integral membrane protein that catalyzes the committed step to acidic phospholipid synthesis, and we show that its overexpression increases the contents of cardiolipin and phosphatidylglycerol. Remarkably, expression of PgsA also stabilizes NG and restores its biological function. Collectively, our results strongly support the notion that FtsY functionally interacts with acidic lipids.