Miracle-dz/UniFAR-FTUs huggingface dataset:
Variability of coastal upwelling south of Madagascar

Madagascar’s southern coastal marine zone is a region of high biological productivity which supports a wide range of marine ecosystems, including fisheries. This high biological productivity is attributed to coastal upwelling. The thesis seeks to characterise the variability of the coastal upwelling south of Madagascar. The first part of the thesis provides new insights on the structure, variability and drivers of the coastal upwelling south of Madagascar. Satellite remote sensing is used to characterize the spatial extent and strength of the coastal upwelling. A front detection algorithm is applied to thirteen years of Multi-scale Ultra-high Resolution (MUR) Sea Surface Temperatures (SST) and an upwelling index is calculated. The influence of winds and ocean currents as drivers of the upwelling are investigated using satellite, in-situ observations, and a numerical model. Results reveal the presence of two well-defined upwelling cells. The first cell (Core 1) is located in the southeastern corner of Madagascar, and the second cell (Core 2) is west of the southern tip of Madagascar. These two cores are characterized by different seasonal variability, different intensities, different upwelled water mass origins, and distinct forcing mechanisms. Core 1 is associated with a dynamical upwelling forced by the detachment of the East Madagascar Current (EMC), which is reinforced by upwelling favourable winds. Core 2 which appears to be primarily forced by upwelling favourable winds, is also influenced by a poleward eastern boundary flow coming from the Mozambique Channel. This intrusion of Mozambique Channel warm waters could result in an asynchronicity in seasonality between upwelling surface signature and upwelling favourables winds. The second part of the thesis focuses on the interaction between the intrusion of warm water from Mozambique channel and the upwelling cell in Core 2. Cruise datasets, satellite remote sensing observations and model data analyses are combined to highlight the existence of a coastal surface poleward flow in the south-west of Madagascar: the South-west MAdagascar
Patients' perceptions of why, how, and by whom dialysis treatment modality was chosen.

OBJECTIVE The purpose of this qualitative study was to elicit patients' perceptions of why, how, and by whom their dialysis treatment modality--hemodialysis or continuous ambulatory peritoneal dialysis (CAPD)--was chosen. DESIGN The study design utilized a naturalistic method of inquiry employing a qualitative approach. The research was guided by the life-death decisions in health care framework developed by Degner and Beaton and the Neuman Systems Model. SAMPLE/SETTING Twenty-two informants were recruited from inpatient and outpatient renal dialysis units at a large urban tertiary care center on the east coast of the United States. METHODS Data were collected by individual, focused, semi-structured in-depth interviews. RESULTS A grounded theory, "Patient's Choice of a Treatment Modality versus Selection of Patient's Treatment Modality" emerged from the data provided by the informants. The theory consisted of 11 themes that addressed the why, how, and by whom of decision-making: self decision; access-rationing decision; significant other decision; to live decision; physiologically dictated decision; expert decision; to-be-cared-for decision; independence verses dependence decision; no patient choice in making decision; patient preference/choice; and switching modalities due to patient preference/choice. CONCLUSION The themes reflected two patterns of decision-making: the patient and/or significant other chose the treatment modality, and the treatment modality was selected because of clinical or practical circumstances.
Manual fixation versus locking during upper cervical segmental mobilization. Part 1: an in vitro three-dimensional arthrokinematic analysis of manual flexion-extension mobilization of the atlanto-occipital joint.

BACKGROUND Segmental manual spinal mobilization techniques are used to restrict the effects of interventions to one spinal segment. It is, however, not known whether it is possible to generate such a localization of effects. Segmental motion in the cervical spine was previously studied by applying pure moments of force on cadaver specimens. So far, no studies have been performed on the segmental three-dimensional (3D)-kinematic aspects of cervical manual flexion-extension mobilization. METHODS 3D-aspects of manual flexion-extension motion in the atlanto-occipital and atlanto-axial segments were analysed in vitro using an electromagnetic tracking device. Segmental bony reference points were registered using a 3D-digitizing stylus to define bone-embedded coordinate frames. Six spinal specimens--five embalmed and one fresh--were analysed in this study. Segmental motions were analysed in the atlanto-occipital and the atlanto-axial joints during manual mobilization through the full range of flexion-extension mobility. The 3D-kinematic analysis of two different segmental mobilization techniques--manual fixation of C1 versus locking of the inferior cervical spine--is presented. RESULTS A significant reduction (P<0.05) of the associated axial rotation and lateral bending motions was observed during the manual fixation technique without influencing the main motion component of flexion-extension. The locking technique did not significantly influence the movements on the mobilized atlanto-occipital segment, but reduced all movement components in the atlanto-axial joint. INTERPRETATIONS The results suggest that, for manual segmental flexion-extension mobilization of the upper cervical spine, manual fixation or locking might be chosen in different situations according to the desired effects.
What can Nonprofit Journalists Actually do for Democracy?

At a time when news organizations are struggling to define and promote their own relevance, some argue that journalists should make explicit their efforts to contribute to democracy as well as the results of those efforts. This study focuses on one prominent nonprofit news organization, the International Consortium of Investigative Journalists (ICIJ), that openly discusses the impact of its work in a way that may point to the beginnings of a new journalistic theory of democracy. We conduct a discourse analysis evaluating ICIJ's own language about three of its high-profile investigative reports into global tax evasion, and discover four ways in which the organization makes reference to the impact of those projects. Ultimately, we argue that this focus on impact—encouraged, at least in part, by the organization's foundation funders—is leading ICIJ to measure its democratic role in a way that sets its behavior apart from traditional journalistic entities, presenting an opportunity for scholars to discuss journalism's evolving role in democracy.
Building life satisfaction through attachment to mother and beliefs about the world: social axioms as mediators in two cultural groups

This study examines the role of three dimensions of social axioms (religiosity, social cynicism, and reward for application) as mediators of the relationship between insecure attachment styles to mother and the life satisfaction of Hong Kong Chinese and Americans. Participants were 143 university students from Hong Kong and 187 from the United States. As predicted, attachment-avoidant individuals had higher levels of social cynicism and lower levels of reward for application, while attachment-anxious individuals showed higher levels of social cynicism. Both social cynicism and reward for application mediated the link between insecure maternal attachment styles and life satisfaction, confirming the position that experiences with mothering shape beliefs about the world that in turn shape life outcomes. Anxious and avoidant maternal attachment styles correlated differently with religiosity, social cynicism, and reward for application in the two cultures, suggesting a distinctive role for beliefs about religious institutions and a Supreme Being for Americans.
Celecoxib inactivates epithelial–mesenchymal transition stimulated by hypoxia and/or epidermal growth factor in colon cancer cells

Celecoxib, a selective cyclooxygenase‐2 (COX‐2) inhibitor, has been reported to exert chemopreventive and antitumor effects on colon cancer, one of the most common solid epithelial malignancy worldwide. The aim of this study was to elucidate whether celecoxib may be able to affect epithelial–mesenchymal transition (EMT), a critical process involved in cancer cell invasiveness and metastasis and then proposed to be relevant for cancer progression. Human HT‐29 colon cancer cells were exposed to carefully controlled hypoxic conditions and/or epidermal growth factor (EGF) and then investigated for EMT changes and signal transduction pathways involved by using morphological, molecular, and cell biology techniques. Celecoxib inhibited basal and EGF‐stimulated proliferation, hypoxia‐related HIF‐1α recruitment/stabilization as well as hypoxia‐ and EGF‐dependent activation of ERK and PI3K. Interestingly, celecoxib prevented EMT‐related changes, as shown by modifications of β‐catenin intracellular localization or vimentin and E‐cadherin levels, as well as HT‐29 invasiveness induced by hypoxia, EGF, or hypoxia plus EGF. Finally, experiments performed on SW‐480 colon cancer cells (i.e., cells lacking COX‐2) exposed to hypoxia, used here as a stimulus able to induce EMT and invasiveness, revealed that in these cells celecoxib was ineffective. Results of the present study indicate that celecoxib has the potential to negatively affect induction of EMT and increased invasiveness of colon cancer cells as elicited by different signals originating from tumor microenvironment (i.e., hypoxia and EGF). Moreover, these effects are likely be related to the pharmacological inhibitory effect exerted on COX‐2 activity. © 2011 Wiley Periodicals, Inc.
Performance appraisal: Stressful for some

Performance appraisal has been generally accepted as being stressful for both appraisers and appraisees. Using pre- and post-measures of the three catecholamine neurotransmitters, namely adrenaline, noradrenaline and cortisol, this paper examined the extent that a performance appraisal interview is stressful for appraisees. It was found that the event was highly stressful for unsuccessful appraisees, both male and female and, further, that unsuccessful appraisees expected a stressful event. Gender differences were found in the study. Males appear to be more physiological responsive while for females, the psychological, rather than the physiological costs may be higher. Finally, the paper explores a number of issues for managers resulting from these findings.
Viewpoint: scaling up testing services for non‐communicable diseases in Africa: priorities for implementation research

The burden of non‐communicable diseases in Africa is rising rapidly and implementation of evidence‐based control strategies is needed urgently. Testing people for hypertension and diabetes will be an important component in the fight against these diseases, as voluntary counselling and testing was for HIV‐infection. We discuss the below the areas where we believe evidence is needed to inform policy.
Passive hip movement measurements related to dynamic motion during gait in hip osteoarthritis

Reduced sagittal plane range of motion (ROM) has been reported in individuals with hip osteoarthritis (OA) both during walking and passive testing. The purpose of this study was to determine if a relationship exists between hip extension ROM recorded during gait and passive hip extension ROM in individuals with moderate and severe hip OA, in comparison to an asymptomatic group. Sagittal plane hip ROM was calculated using skin surface marker trajectories captured during treadmill walking at self‐selected speed. Passive hip ROM was measured using standardized position and recording procedures with a goniometer. Sagittal plane extension, flexion, and overall ROM were measured dynamically and passively. A two‐way mixed model analysis of variance determined significant differences between groups and between passive and dynamic ROM (α = 0.05). Pearson correlations determined relationships between passive and dynamic ROM. Significant group by ROM interactions were found for flexion and extension ROM (p < 0.05). For extension, the severe OA group had less dynamic and passive ROM compared to the other groups and greater passive than dynamic ROM (p < 0.05). For flexion, significant differences in passive ROM existed between all three groups (p < 0.05) whereas no differences were found for dynamic flexion (p < 0.05). Significant correlations between dynamic and passive hip extension were found in the moderate (r = 0.596) and severe OA (r = 0.586) groups, and no correlation was found in the asymptomatic group (r = 0.139). Passive ROM explains variance in dynamic ROM measurements obtained during gait in individuals with moderate and severe hip OA which have implications for the design of treatment strategies targeting walking pathomechanics. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1790–1797, 2016.
Determinants of Daily Happiness on Vacation

How happy are tourists during a day of their holiday and what makes them happy? These questions were addressed in a study of 466 international tourists in the Netherlands. While on vacation, tourists are generally high on hedonic level of affect, with positive affect exceeding negative affect almost fourfold. Affect balance is higher than generally observed in everyday life, whereas tourists’ life satisfaction is not significantly different compared with life satisfaction in their everyday life. Vacationers’ socioeconomic backgrounds and life satisfaction only partially explain their affective state of the day. Most of the variance is explained by factors associated with the holiday trip itself. During a holiday, holiday stress and attitude toward the travel party are the most important determinants of daily affect balance. These findings imply that on the whole, the tourism industry is doing a good job. The industry could probably do better with more research on experiences during the holiday.
Identification of Nitrite-Oxidizing Bacteria with Monoclonal Antibodies Recognizing the Nitrite Oxidoreductase

ABSTRACT Immunoblot analyses performed with three monoclonal antibodies (MAbs) that recognized the nitrite oxidoreductase (NOR) of the genus Nitrobacter were used for taxonomic investigations of nitrite oxidizers. We found that these MAbs were able to detect the nitrite-oxidizing systems (NOS) of the generaNitrospira, Nitrococcus, andNitrospina. The MAb designated Hyb 153-2, which recognized the α subunit of the NOR (α-NOR), was specific for species belonging to the genus Nitrobacter. In contrast, Hyb 153-3, which recognized the β-NOR, reacted with nitrite oxidizers of the four genera. Hyb 153-1, which also recognized the β-NOR, bound to members of the generaNitrobacter and Nitrococcus. The molecular masses of the β-NOR of the genusNitrobacter and the β subunit of the NOS (β-NOS) of the genus Nitrococcus were identical (65 kDa). In contrast, the molecular masses of the β-NOS of the generaNitrospina and Nitrospira were different (48 and 46 kDa). When the genus-specific reactions of the MAbs were correlated with 16S rRNA sequences, they reflected the phylogenetic relationships among the nitrite oxidizers. The specific reactions of the MAbs allowed us to classify novel isolates and nitrite oxidizers in enrichment cultures at the genus level. In ecological studies the immunoblot analyses demonstrated thatNitrobacter or Nitrospira cells could be enriched from activated sludge by using various substrate concentrations. Fluorescence in situ hybridization and electron microscopic analyses confirmed these results. Permeated cells of pure cultures of members of the four genera were suitable for immunofluorescence labeling; these cells exhibited fluorescence signals that were consistent with the location of the NOS.
Organizational Commitment and Conflicting Values: The Impact of Systems of Norms in Six Western Countries

This study compares organizational commitment in six western countries: USA, Great Britain, New Zealand, Germany, Norway, and Sweden. The main focus is on the hypothesized existence of conflicting values due to different systems of norms. The assumption made is that the central norms, values, and expectations in any particular work organization, originate in a more general technical/economic system of norms; and that subordinated groups, supporters of left-wing values, those identifying with lower social classes, and union members all espouse other systems of norms, which are not entirely compatible with this technical/economic system, and that these groups are therefore likely to display lower organizational commitment than other groups. The results in this paper do suggest the existence of conflicting norms and that this has implications for organizational commitment. The most noteworthy finding is that organizational commitment correlates with right-wing political values in five of the six countries. Other similarities and differences between the countries are also identified and discussed, and new avenues for further comparative research are suggested.
Democracy and spiritual awareness: interconnections and implications for educational leadership

This article sets out theorisations of developmental democracy and spiritual awareness formulated in previous work by the authors. These are used to explore collegial leadership in a case study Steiner school, with the aim of illuminating and illustrating the transformative demands of developmental democracy and its interconnection with spiritual awareness. The article concludes with a discussion of implications for imbuing democratised educational leadership with spiritual energy and fashioning and leading a school environment that reflects the model of developmental democracy.
The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche

Many tissues contain adult mesenchymal stem cells (MSCs), which may be used in tissue regeneration therapies. However, the MSC availability in most tissues is limited which demands expansion in vitro following isolation. Like many developing cells, the state of MSCs is affected by the surrounding microenvironment, and mimicking this natural microenvironment that supports multipotent or differentiated state in vivo is essential to understand for the successful use of MSC in regenerative therapies. Many researchers are, therefore, optimizing cell culture conditions in vitro by altering growth factors, extracellular matrices, chemicals, oxygen tension, and surrounding pH to enhance stem cells self-renewal or differentiation. Insulin-like growth factors (IGFs) system has been demonstrated to play an important role in stem cell biology to either promote proliferation and self-renewal or enhance differentiation onset and outcome, depending on the cell culture conditions. In this review, we will describe the importance of IGFs, IGF-1 and IGF-2, in development and in the MSC niche and how they affect the pluripotency or differentiation towards multiple lineages of the three germ layers.
Polymorphisms in the mTOR Gene and Risk of Sporadic Prostate Cancer in an Eastern Chinese Population

Background The mTOR gene regulates cell growth by controlling mRNA translation, ribosome biogenesis, autophagy, and metabolism. Abnormally increased expression of mTOR was associated with carcinogenesis, and its functional single nucleotide polymorphisms (SNPs) may regulate the expression of mTOR and thus contribute to cancer risk. Methodology/Principal Findings In a hospital-based case-control study of 1004 prostate cancer (PCa) cases and 1051 cancer-free controls, we genotyped six potentially functional SNPs of mTOR (rs2536 T>C, rs1883965 G>A, rs1034528 G>C, rs17036508 T>C, rs3806317 A>G, and rs2295080 T>G) and assessed their associations with risk of PCa by using logistic regression analysis. Conclusions/Significances In the single-locus analysis, we found a significantly increased risk of PCa associated with mTOR rs2536 CT/CC and rs1034528 CG/CC genotypes [adjusted OR = 1.42 (1.13–1.78), P = 0.003 and 1.29 (1.07–1.55), P = 0.007), respectively], compared with their common homozygous genotypes, whereas mTOR rs2295080 GT/GG genotypes were associated with a decreased risk of PCa [adjusted OR = 0.76 (0.64–0.92), P = 0.003], compared with wild-type TT genotypes. In the combined analysis of the six SNPs, we found that individuals carrying two or more adverse genotypes had an increased risk of PCa [adjusted OR = 1.24 (1.04–1.47), P = 0.016], compared with individuals carrying less than two adverse genotypes. In the multiple dimension reduction analysis, body mass index (BMI) was the best one-factor model with the highest CVC (100%) and the lowest prediction error (42.7%) among all seven factors. The model including an interaction among BMI, rs17036508, and rs2536 was the best three-factor model with the highest CVC (100%) and the lowest prediction error of 41.9%. These findings suggested that mTOR SNPs may contribute to the risk of PCa in Eastern Chinese men, but the effect was weak and needs further validation by larger population-based studies.
Accelerated Metabolism and Exclusion of 4-Hydroxynonenal through Induction of RLIP76 and hGST5.8 Is an Early Adaptive Response of Cells to Heat and Oxidative Stress*

To explore the role of lipid peroxidation (LPO) products in the initial phase of stress mediated signaling, we studied the effect of mild, transient oxidative or heat stress on parameters that regulate the cellular concentration of 4-hydroxynonenal (4-HNE). When K562 cells were exposed to mild heat shock (42 °C, 30 min) or oxidative stress (50 μmH2O2, 20 min) and allowed to recover for 2 h, there was a severalfold induction of hGST5.8, which catalyzes the formation of glutathione-4-HNE conjugate (GS-HNE), and RLIP76, which mediates the transport of GS-HNE from cells (Awasthi, S., Cheng, J., Singhal, S. S., Saini, M. K., Pandya, U., Pikula, S., Bandorowicz-Pikula, J., Singh, S. V., Zimniak, P., and Awasthi, Y. C. (2000) Biochemistry 39, 9327–9334). Enhanced LPO was observed in stressed cells, but the major antioxidant enzymes and HSP70 remained unaffected. The stressed cells showed higher GS-HNE-conjugating activity and increased efflux of GS-HNE. Stress-pre-conditioned cells with induced hGST5.8 and RLIP76 acquired resistance to 4-HNE and H2O2-mediated apoptosis by suppressing a sustained activation of c-Jun N-terminal kinase and caspase 3. The protective effect of stress pre-conditioning against apoptosis was abrogated by coating the cells with anti-RLIP76 IgG, which inhibited the efflux of GS-HNE from cells, indicating that the cells acquired resistance to apoptosis by metabolizing and excluding 4-HNE at a higher rate. Induction of hGST5.8 and RLIP76 by mild, transient stress and the resulting resistance of stress-pre-conditioned cells to apoptosis appears to be a general phenomenon since it was not limited to K562 cells but was also evident in lung cancer cells, H-69, H-226, human leukemia cells, HL-60, and human retinal pigmented epithelial cells. These results strongly suggest a role of LPO products, particularly 4-HNE, in the initial phase of stress mediated signaling.