Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of a Dermal Regeneration Template in Complicated Craniotomy Wounds: Review of a Series

BACKGROUND: Surgical wounds after craniotomy heal with primary closure in most cases; however, significant comorbidities, multiple procedures, and history of tumor increase the risk of wound breakdown. Craniotomy wounds often require sophisticated coverage by a plastic surgeon using regional or microvascular flaps to address exposed intracranial contents. Unfortunately, timely treatment of craniotomy wounds may be difficult as a result of limitations of plastic surgery consultation, specialized operating room staffing, and operating room time. Infected wounds may need serial debridement and antibiotic therapy before definitive closure, and patients with dehisced or infected craniotomy wounds may need medical and nutritional optimization. OBJECTIVE: To present the first case series of 7 neurosurgical patients with craniotomy wound complications who underwent closure with dermal regeneration template (DRT) at the time of urgent surgical debridement. METHODS: Seven adult patients underwent placement of DRT for dehisced or infected craniotomy wounds after treatment for tumor or trauma. Patients had an average of 5.5 operations before definitive closure. Six patients ultimately underwent delayed free flap transfer after DRT placement, and 1 patient had DRT as definitive coverage. RESULTS: All patients had healed craniotomy wounds. CONCLUSION: DRT has a role in treating complicated craniotomy wounds in patients with cancer or trauma either as a bridge or as definitive coverage. Its ease of application does not require advanced or time-consuming techniques. In some cases, it may even be used as a definitive means of closure in surgical wounds. ABBREVIATION: DRT, dermal regeneration template
Anthophyllite asbestos: state of the science review

Anthophyllite is an amphibole form of asbestos historically used in only a limited number of products. No published resource currently exists that offers a complete overview of anthophyllite toxicity or of its effects on exposed human populations. We performed a review focusing on how anthophyllite toxicity was understood over time by conducting a comprehensive search of publicly available documents that discussed the use, mining, properties, toxicity, exposure and potential health effects of anthophyllite. Over 200 documents were identified; 114 contained relevant and useful information which we present chronologically in this assessment. Our analysis confirms that anthophyllite toxicity has not been well studied compared to other asbestos types. We found that toxicology studies in animals from the 1970s onward have indicated that, at sufficient doses, anthophyllite can cause asbestosis, lung cancer and mesothelioma. Studies of Finnish anthophyllite miners, conducted in the 1970s, found an increased incidence of asbestosis and lung cancer, but not mesothelioma. Not until the mid‐1990s was an epidemiological link with mesothelioma in humans observed. Its presence in talc has been of recent significance in relation to potential asbestos exposure through the use of talc‐containing products. Characterizing the health risks of anthophyllite is difficult, and distinguishing between its asbestiform and non‐asbestiform mineral form is essential from both a toxicological and regulatory perspective. Anthophyllite toxicity has generally been assumed to be similar to other amphiboles from a regulatory standpoint, but some notable exceptions exist. In order to reach a more clear understanding of anthophyllite toxicity, significant additional study is needed. Copyright © 2016 John Wiley & Sons, Ltd.
SV2: Accurate Structural Variation Genotyping and De Novo Mutation Detection from Whole Genomes

Motivation Structural Variation (SV) detection from short-read whole genome sequencing is error prone, presenting significant challenges for population or family-based studies of disease. Results Here we describe SV2, a machine-learning algorithm for genotyping deletions and duplications from paired-end sequencing data. SV2 can rapidly integrate variant calls from multiple structural variant discovery algorithms into a unified call set with high genotyping accuracy and capability to detect de novo mutations. Availability and Implementation SV2 is freely available on GitHub (https://github.com/dantaki/SV2)
Overexpression of miR-191 Predicts Poor Prognosis and Promotes Proliferation and Invasion in Esophageal Squamous Cell Carcinoma

Purpose Accumulating evidence has shown that dysregulation of microRNA-191 (miR-191) is closely associated with tumorigenesis and progression in a wide range of cancers. This study aimed to explore the potential role of miR-191 in esophageal squamous cell carcinoma (ESCC). Materials and Methods miR-191 expression was assessed in 93 ESCC tissue specimens by real-time polymerase chain reaction, and survival analysis was performed via Kaplan-Meier and Cox regression analyses. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, plate colony-forming, BrdU, and Transwell assays were conducted to observe the effect of miR-191 on ESCC proliferation and invasion. Luciferase reporter and western blot assays were taken to identify target genes of miR-191. Results miR-191 was overexpressed in 93 cases of ESCC, compared with adjacent normal tissues, and miR-191 expression was significantly related to differentiation, depth of invasion, TNM stage, lymph node metastasis, and distant metastasis of tumor. Kaplan-Meier and Cox regression analyses demonstrated that overexpression of miR-191 was an independent and significant predictor of ESCC prognosis. Both gain-of-function and loss-of-function experiments showed that miR-191 promoted ESCC cell proliferation and invasion activities in vitro. Early growth response 1 (EGR1), a tumor suppressor, was predicted as a direct target of miR-191. Luciferase reporter and western blot assays proved that miR-191 reduced EGR1 expression by directly binding its 3' untranslated region. Moreover, EGR1 knockdown by siRNA enhanced ESCC cell growth and invasion. Conclusion Our findings provide specific biological roles of miR-191 in ESCC survival and progression. Targeting the novel miR-191/EGR1 axis represents a potential new therapeutic way to block ESCC development.
Dynamics of Water Vapor Transmission through Fabric Barriers

An experimental apparatus has been developed to permit the simultaneous measurement of moisture sorption by a fabric and moisture flux through a fabric during the transient period after the fabric is exposed to a humidity gradient. By suitable manipulation of the experimental conditions, the method demonstrates that moisture flux occurs predominantly through the air spaces of the fabric; the role of the fibers is to act as a moisture source or sink. Two mathematical descriptions of the transient period have been developed, in which the interaction between moisture sorption by the fibers and moisture flux through the air spaces of a fabric is modeled. In the first model, the dominant mass transfer resistance for the sorption process is considered to be diffusion of water molecules through the air to the fiber surface. Diffusion within the fiber is considered to be so rapid that the fiber moisture content is always in sorptive equilibrium with the air at the fiber surface. This simple model correctly predicts the qualitative trends exhibited by experimental data collected on fabrics of widely varying sorptive capacity, but it under-predicts the duration of the transient period for a large proportion of these fabrics. A more realistic and complex model is also presented, in which the dominant mass transfer resistance is molecular diffusion of water molecules within the fiber interior. In this case the fiber moisture content lags behind the changes in the moisture content of the air at the fiber surface. The added complexity of this model provides a more accurate fit to the experimental data, although the correction provided by accounting for intrafiber diffusional resistance is small compared to the effect of sorptive capacity.
Formation of pH-Resistant Monodispersed Polymer-Lipid Nanodiscs.

Polymer lipid nanodiscs are an invaluable system for structural and functional studies of membrane proteins in their near-native environment. Despite the recent advances in the development and usage of polymer lipid nanodisc systems, lack of control over size and poor tolerance to pH and divalent metal ions are major limitations for further applications. A facile modification of a low-molecular-weight styrene maleic acid copolymer is demonstrated to form monodispersed lipid bilayer nanodiscs that show ultra-stability towards divalent metal ion concentration over a pH range of 2.5 to 10. The macro-nanodiscs (>20 nm diameter) show magnetic alignment properties that can be exploited for high-resolution structural studies of membrane proteins and amyloid proteins using solid-state NMR techniques. The new polymer, SMA-QA, nanodisc is a robust membrane mimetic tool that offers significant advantages over currently reported nanodisc systems.
Heat Transfer and Friction in Rectangular Duct with Pin-Fin Arrays

This study involves an experimental investigation of pin-fin heat sinks have circular, square and diamond crosssections. Ensemble of pin-fin heat sinks with in-line and staggered arrangements were designed and tested. The fin density effect on heat transfer and friction characteristics is examined. The channel cross section is of 150 mm x 200 mm. The experiments covered the following ranges: Reynolds number 2000 to 25000, clearance ratio (C/H) 0.0 to 0.50 and inter-fin spacing ratio (Sy/d= 1.2 to 22.8 and Sx/d =1.2 to 10). In all, the circular pin-fin arrangement shows an appreciable influence of fin density and whereas no effect is seen in case of square fin geometry. This is associated with the unique deflection flow pattern accompanied with the in-line circular fin configuration. For the staggered arrangement, the heat transfer coefficient increases with the rise of fin density with the penalty of pressure drop. However, diamond pin-fin results the lowest pressure drop with better performance than that square configuration.
Prenatal Exposure to DEHP Induces Premature Reproductive Senescence in Male Mice

Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used phthalate, and it is an endocrine-disrupting chemical. This study tested a hypothesis that prenatal exposure to DEHP lays the foundation for premature gonadal dysfunction and subsequent reproductive senescence in male mice. Pregnant female CD-1 mice were orally dosed with vehicle control (tocopherol-stripped corn oil) or with 20 μg/kg/day, 200 μg/kg/day, 500 mg/kg/day, or 750 mg/kg/day of DEHP from gestational day 11 to birth. Overall, the prenatal DEHP exposure did not cause any overt physical health problems in male offspring, as no significant differences in their body nor gonadal weight were seen up to the age of 23 months. However, an age- and dose-dependent gonadal dysfunction was observed. As early as 7 months of age, the 750 mg/kg/day group of mice exhibited significantly reduced fertility. At 19 months of age, 86% of the 750 mg/kg/day mice became infertile, whereas only 25% of the control mice were infertile. At this age, all of the DEHP-exposed mice had lower serum testosterone levels, higher serum estradiol levels, and higher LH levels compared with control mice. Histological evaluations showed that mice prenatally exposed to DEHP displayed a wide array of gonadal and epididymal abnormalities such as increased germ cell apoptosis, degenerative seminiferous tubules, oligozoospermia, asthenozoospermia, and teratozoospermia in comparison to age-matching control mice. In summary, this study shows that prenatal exposure to DEHP induces premature reproductive senescence in male mice.
SuperQuant-assisted comparative proteome analysis of glioblastoma subpopulations allows for identification of potential novel therapeutic targets and cell markers

Glioblastoma (GBM) is a highly aggressive brain cancer with poor prognosis and low survival rate. Invasive cancer stem-like cells (CSCs) are responsible for tumor recurrence because they escape current treatments. Our main goal was to study the proteome of three GBM subpopulations to identify key molecules behind GBM cell phenotypes and potential cell markers for migrating cells. We used SuperQuant–an enhanced quantitative proteome approach–to increase proteome coverage. We found 148 proteins differentially regulated in migrating CSCs and 199 proteins differentially regulated in differentiated cells. We used Ingenuity Pathway Analysis (IPA) to predict upstream regulators, downstream effects and canonical pathways associated with regulated proteins. IPA analysis predicted activation of integrin-linked kinase (ILK) signaling, actin cytoskeleton signaling, and lysine demethylase 5B (KDM5B) in CSC migration. Moreover, our data suggested that microRNA-122 (miR-122) is a potential upstream regulator of GBM phenotypes as miR-122 activation was predicted for differentiated cells while its inhibition was predicted for migrating CSCs. Finally, we validated transferrin (TF) and procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2) as potential markers for migrating cells.
Lower hippocampal subfields volume in relation to anxiety in medication-overuse headache

Background Hippocampus (HIP) was an important limbic structure, and concurrent emotion disorders may occur in medication-overuse headache patients. The aim of this study is to investigate altered HIP and HIP subfields volume in relation with the anxiety in medication-overuse headache patients using a state-of-the-art hippocampal segment method. Results The current study presented that a significant lower HIP and HIP subfields volume were identified in medication-overuse headache compared with that in normal controls except right HIP tail, bilateral parasubiculums, and HIP fissure. The left HIP and right subiculum presented negative correlation with headache variables, and the right subiculum, Cornu Ammonis 4, granule cell layer of dentate gyrus, bilateral Cornu Ammonis 1, molecular layer, and whole HIP presented negative correlation with Hamilton Anxiety Scale score, which were further confirmed by the linear regression analysis with the exclusion of psychological variables and headache variables, respectively. Conclusions The lower HIP and HIP subfields volume were identified in medication-overuse headache patients, and negatively related with anxiety condition. The potential mechanism for the comorbidity medication-overuse headache and anxiety might be interpreted as the reciprocal causation relationship and co-occurrence relationship.
UTILIZATION OF PULVERIZED PLASTIC IN CEMENT CONCRETE AS FINE AGGREGATE

Disposal of used Plastics is a major problem in the present era, as the usage of plastics is growing day by day and it takes hundreds of years for plastic material to degrade. So effective ways to recycle & reuse of plastics are being formulated. According to their composition, plastics have been classified into seven types each having their own recycle rate. One such type HDPE (High Density Polyethylene) was taken into consideration as it was easily available & had higher density than other types. The used plastics were collected , ground into smaller components , melted & pulverized in order to get granules of plastic of about 1mm size. The density of the Pulverized plastic was found to be 460 kg/m 3 & its specific gravity was 0.46. Sieve analyses were carried out & about 75% of the plastics were found to be in the range of 1 -1.7mm. 45 nos. of 15cm x15cm x15cm cement concrete Cubes of 1:1:2 (M 25) mix were cast for 0% ,25% , 50% , 75% , 100 % sand being replaced with Pulverized plastic material. Volumetric proportioning was adopted instead of design mix since the density of plastic material was too low. Workability test, weight and compressive strength of the cubes were determined. The test results revealed that the yield as well as the ultimate strength of concrete at seventh day decreased by about 3 to 3.2 N/mm 2 for 25%replacement & 4 to 6.5 N/mm 2 for higher replacements of Plastic when compared to conventional concrete The ultimate as well as the yield strength of concrete at 14 th day & 28 th day decreased by about 0.2 to 1 N/mm 2 for 25%replacement & 9.1 to 14.6 N/mm 2 for higher replacements of Plastic when compared to conventional concrete The water Cement ratio was also found to increase with the proportion of Plastics for a slump of 10 mm & weight of the cube decreased with an increase in replacement of Sand by Plastic Material. Thus it is inferred that Replacement of sand by plastic up to 25% can be adopted so that disposal of used plastic can be done as well the deficiency of Natural aggregates can be managed effectively.
A Threshold Neuron Pruning for a Binarized Deep Neural Network on an FPGA

SUMMARY For a pre-trained deep convolutional neural network (CNN) for an embedded system, a high-speed and a low power consumption are required. In the former of the CNN, it consists of convolutional layers, while in the latter, it consists of fully connection layers. In the convolutional layer, the multiply accumulation operation is a bottleneck, while the fully connection layer, the memory access is a bottleneck. The binarized CNN has been proposed to realize many multiply accumulation circuit on the FPGA, thus, the convolutional layer can be done with a high-seed operation. However, even if we apply the binarization to the fully connection layer, the amount of memory was still a bottleneck. In this paper, we propose a neuron pruning technique which eliminates almost part of the weight memory, and we apply it to the fully connection layer on the binarized CNN. In that case, since the weight memory is realized by an on-chip memory on the FPGA, it achieves a high-speed memory access. To further reduce the memory size, we apply the retraining the CNN after neuron pruning. In this paper, we propose a sequential-input parallel-output fully connection layer circuit for the binarized fully connection layer, while proposing a streaming circuit for the binarized 2D convolutional layer. The experimental results showed that, by the neuron pruning, as for the fully connected layer on the VGG-11 CNN, the number of neurons was reduced by 39.8% with keeping the 99% baseline accuracy. We implemented the neuron pruning CNN on the Xilinx Inc. Zynq Zedboard. Compared with the ARM Cortex-A57, it was 1773.0 times faster, it dissipated 3.1 times lower power, and its performance per power e ﬃ ciency was 5781.3 times better. Also, compared with the Maxwell GPU, it was 11.1 times faster, it dissipated 7.7 times lower power, and its performance per power e ﬃ ciency was 84.1 times better. Thus, the binarized CNN on the FPGA is suitable for the embedded system.
A Climatology of the Extratropical Transition of Atlantic Tropical Cyclones.

Abstract A comprehensive climatology of extratropically transitioning tropical cyclones in the Atlantic basin is presented. Storm tracks and intensities over a period from 1899 to 1996 are examined. More detailed statistics are presented only for the most reliable period of record, beginning in 1950. Since 1950, 46% of Atlantic tropical cyclones transitioned to the extratropical phase. The coastal Atlantic areas most likely to be impacted by a transitioning tropical cyclone are the northeast United States and the Canadian Maritimes (1–2 storms per year), and western Europe (once every 1–2 yr). Extratropically transitioning tropical cyclones represent 50% of landfalling tropical cyclones on the east coasts of the United States and Canada, and the west coast of Europe, combined. The likelihood that a tropical cyclone will transition increases toward the second half of the tropical season, with October having the highest probability (50%) of transition. Atlantic transition occurs from 24° to 55°N, with a muc.
Explosive and maximal strength before and 6 months after total hip arthroplasty

Patients with unilateral hip osteoarthritis experience impairments in lower limb muscle function due to pain and disuse of the affected limb. The influence of hip osteoarthritis and subsequent total hip arthroplasty (THA) has mostly been evaluated by maximal strength tests, yet the functionally important explosive strength capabilities of hip and knee muscles are largely unknown. We aimed to evaluate hip and knee explosive and maximal strength in hip osteoarthritis patients before and after THA. Twenty‐one patients with unilateral hip osteoarthritis were evaluated before and 6 months after THA. They performed rapid maximal contractions of hip (flexor, extensor, abductor, adductor) and knee (flexor, extensor) muscles, from which explosive and maximal strength asymmetries were evaluated (involved versus uninvolved limb). Before THA, the involved limb showed significantly lower hip flexor, extensor, adductor, and knee extensor explosive and maximal strength compared to the uninvolved limb. Six months after THA surgery, hip flexor, extensor and adductor maximal and explosive strength asymmetries persisted, except for knee extensors. Explosive, but not maximal strength of hip abductors and knee extensors was lower in the involved limb before surgery and the reduced explosive strength capabilities may compromise daily living activities in hip osteoarthritis patients. After hip replacement, explosive strength asymmetries of knee extensors resolved, yet lingering asymmetries in hip flexor muscles should receive focused attention during postoperative rehabilitation. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:425–431, 2018.
Large System Analysis of Cooperative Multi-Cell Downlink Transmission via Regularized Channel Inversion with Imperfect CSIT

In this paper, we analyze the ergodic sum-rate of a multi-cell downlink system with base station (BS) cooperation using regularized zero-forcing (RZF) precoding. Our model assumes that the channels between BSs and users have independent spatial correlations and imperfect channel state information at the transmitter (CSIT) is available. Our derivations are based on large dimensional random matrix theory (RMT) under the assumption that the numbers of antennas at the BS and users approach to infinity with some fixed ratios. In particular, a deterministic equivalent expression of the ergodic sum-rate is obtained and is instrumental in getting insight about the joint operations of BSs, which leads to an efficient method to find the asymptotic-optimal regularization parameter for the RZF. In another application, we use the deterministic channel rate to study the optimal feedback bit allocation among the BSs for maximizing the ergodic sum-rate, subject to a total number of feedback bits constraint. By inspecting the properties of the allocation, we further propose a scheme to greatly reduce the search space for optimization. Simulation results demonstrate that the ergodic sum-rates achievable by a subspace search provides comparable results to those by an exhaustive search under various typical settings.