Miracle-dz/UniFAR-FTUs huggingface dataset:
Present and LGM permafrost from climate simulations: contribution of statistical downscaling.

Abstract. We quantify the agreement between permafrost distributions from PMIP2 (Paleoclimate Modeling Intercomparison Project) climate models and permafrost data. We evaluate the ability of several climate models to represent permafrost and assess the inter-variability between them. Studying an heterogeneous variable such as permafrost implies to conduct analysis at a smaller spatial scale compared with climate models resolution. Our approach consists in applying statistical downscaling methods (SDMs) on large- or regional-scale atmospheric variables provided by climate models, leading to local permafrost modelling. Among the SDMs, we first choose a transfer function approach based on Generalized Additive Models (GAMs) to produce high-resolution climatology of surface air temperature (SAT). Then, we define permafrost distribution over Eurasia by SAT conditions. In a first validation step on present climate (CTRL period), GAM shows some limitations with non-systemic improvements in comparison with the large-scale fields. So, we develop an alternative method of statistical downscaling based on a stochastic generator approach through a Multinomial Logistic Regression (MLR), which directly models the probabilities of local permafrost indices. The obtained permafrost distributions appear in a better agreement with data. In both cases, the provided local information reduces the inter-variability between climate models. Nevertheless, this also proves that a simple relationship between permafrost and the SAT only is not always sufficient to represent local permafrost. Finally, we apply each method on a very different climate, the Last Glacial Maximum (LGM) time period, in order to quantify the ability of climate models to represent LGM permafrost. Our SDMs do not significantly improve permafrost distribution and do not reduce the inter-variability between climate models, at this period. We show that LGM permafrost distribution from climate models strongly depends on large-scale SAT. The differences with LGM data, larger than in the CTRL period, reduce the contribution of downscaling and depend on several factors deserving further studies.
Bayesian Approach with Maximum Entropy Principle for trusted quality of Web service metric in e-commerce applications

Trusted quality of Web service (QoWS) issue is critical for e-commerce applications. However, many existing studies have little work in situations that have insufficient or no historical information regarding QoWS data. In this study, we propose a trusted QoWS metric approach, that is, Bayesian Approach with Maximum Entropy Principle. The key of our proposed approach is to extract QoWS prior distribution of Web service by using Maximum Entropy Principle and then to infer QoWS posterior distribution of Web service by using Bayesian Approach. On the basis of the obtained QoWS posterior distribution, trusted QoWS can be measured. We conduct extensive simulations to evaluate our proposed approach. The simulation results demonstrate that our proposed approach can obtain trusted QoWS effectively. Copyright © 2012 John Wiley & Sons, Ltd.
The Comparative Advantages of Firms, Markets and Contracts: A Unified Theory

type="main" xml:id="ecca12109-abs-0001"> The most efficient labour market mechanism depends on the advantages of specialization, workers’ costs of switching between entrepreneurs, and the frequency with which needs change. Multilateral mechanisms are more efficient when specialization is more advantageous, when it is cheap for workers to switch between entrepreneurs, and when individual entrepreneurs cannot occupy a worker on a full-time basis. Given a bilateral mechanism, employment (a firm) is more efficient than contracts when in-process adjustments arise more frequently. There exist three regions in which firms, markets and sequences of bilateral contracts are weakly more efficient than all other mechanisms in a big class.
Novel plasticity rule can explain the development of sensorimotor intelligence

Significance To find how autonomous behavior and its development can be realized by a brain or an artificial neural network is a fundamental challenge for neuroscience and robotics. Commonly, the self-organized unfolding of behavior is explained by postulating special concepts like internal drives, curiosity, specific reward systems, or selective pressures. We propose a simple, local, and biologically plausible synaptic mechanism that enables an embodied agent to self-organize its individual sensorimotor development without recourse to such higher-level constructs. When applied to robotic systems, a rich spectrum of rhythmic behaviors emerges, ranging from locomotion patterns to spontaneous cooperation between partners. A possible utilization of our novel mechanism in nature would lead to a new understanding of the early stages of sensorimotor development and of saltations in evolution. Grounding autonomous behavior in the nervous system is a fundamental challenge for neuroscience. In particular, self-organized behavioral development provides more questions than answers. Are there special functional units for curiosity, motivation, and creativity? This paper argues that these features can be grounded in synaptic plasticity itself, without requiring any higher-level constructs. We propose differential extrinsic plasticity (DEP) as a new synaptic rule for self-learning systems and apply it to a number of complex robotic systems as a test case. Without specifying any purpose or goal, seemingly purposeful and adaptive rhythmic behavior is developed, displaying a certain level of sensorimotor intelligence. These surprising results require no system-specific modifications of the DEP rule. They rather arise from the underlying mechanism of spontaneous symmetry breaking, which is due to the tight brain body environment coupling. The new synaptic rule is biologically plausible and would be an interesting target for neurobiological investigation. We also argue that this neuronal mechanism may have been a catalyst in natural evolution.
The neurotic employee: Theoretical analysis of the influence of narrow facets of neuroticism on cognitive, social, and behavioral processes relevant to job performance

In this chapter, we argue that despite the fact that empirical research on trait neuroticism has shown fairly weak relations between the broad neuroticism trait and overall job performance, organizational research can benefit by increased attention to the neuroticism construct. This is because the influence of neuroticism on work behavior can be best understood by separating the more general neuroticism domain into its lower level facets. We discuss various conceptualizations of neuroticism and then review existing research on the relation between the facets of neuroticism and job performance. Next, we turn our attention to a theoretical framework that suggests that the relations between neuroticism facets and job performance outcomes are explained by the social, cognitive, and behavioral effects of having varying levels of neuroticism-based traits. In so doing, we not only focus on mediated relationships between facets of neuroticism and job performance dimensions but also recognize some important moderators, as well as some expected direct relations between the facets and job performance. Finally, we discuss implications for further conceptual development, offer some suggestions for testing the propositions, and discuss potential practical implications of finding support for this model.
A Wearable Multimodal Interface for Exploring Urban Points of Interest

Locating points of interest (POIs) in cities is typically facilitated by visual aids such as paper maps, brochures, and mobile applications. However, these techniques require visual attention, which ideally should be on the surroundings. Non-visual techniques for navigating towards specific POIs typically lack support for free exploration of the city or more detailed guidance. To overcome these issues, we propose a multimodal, wearable system for alerting the user of nearby recommended POIs. The system, built around a tactile glove, provides audio-tactile cues when a new POI is in the vicinity, and more detailed information and guidance if the user expresses interest in this POI. We evaluated the system in a field study, comparing it to a visual baseline application. The encouraging results show that the glove-based system helps keep the attention on the surroundings and that its performance is on the same level as that of the baseline.
Increasing Participation and Improving Engagement in Home Visitation: A Qualitative Study of Early Head Start Parent Perspectives

Home visitation programs are designed to provide comprehensive services that promote parent's abilities to create stable, nurturing care environments for their children. In order for program goals to be met, parents must participate actively and be engaged with the programs' mission. However, promoting engagement and participation are complex processes that have been understudied in research on home visitation. The current qualitative study examined how a national, federally funded home visitation program, Early Head Start (EHS), engaged and retained families so that potentially helpful preventative interventions could be delivered. The study also identified barriers to active engagement. Semistructured interviews were conducted with 10 parents of children enrolled in EHS. Findings suggest that engagement increased when EHS reduced social isolation by forming connections among parents and when the program focused on involving parents in fostering their children's meeting of important developmental milestones. Barriers to engagement identified included logistical and organizational challenges, as well as parental biases and differences in values and attitudes. Practice and policy recommendations for improving EHS and other programs that serve similar populations to increase engagement are discussed.
The Study of Sexual Satisfaction in Iranian Women Applying for Divorce

Background Marital instability is affected by many factors. In Iran, socio-cultural and political limitations are obstacles for sexuality-related studies; therefore, insufficient in- formation is available in this area. In the present research, we investigated the relation- ship between marital instability and sexual satisfaction among Iranian women. Materials and Methods A case-control study was carried out to investigate women ap- plying for divorce in comparison with our controls during 2011 to 2012 in Isfahan, Iran. Data gathering was done using a questionnaire including two parts: socio-demographic information and factors influencing sexual satisfaction. Larson Inventory of Sexual Sat- isfaction for determining sexual satisfaction was used to determine sexual satisfaction. Results Divorce rate is significantly related to sexual satisfaction (p=0.009). There were also significant relationships between sexual satisfaction and the following variables: age, economic status, amount of income, duration of marriage, number of children, hous- ing, alcohol/drug abuse by spouse, being beaten by spouse, compulsory marriage, second marriage of spouse, and being happy with current partner. Conclusion Sexual satisfaction plays an important role in marital stability of Iranian women. Thus, development of practical strategies in order to provide cultural intervention is needed to improve Iranian couples’ awareness of their sexual relationship. Indeed, train- ings in communication skills through sexual encounters are essential.
Individual variation in neural correlates of sadness in children: A twin fMRI study

Functional neuroimaging studies show substantial individual variation in brain activation accompanying the experience of emotion, including sadness. Here we used functional magnetic resonance imaging (fMRI) in 104 pairs of 8‐year‐old twins (47 MZ, 57 DZ) to assess genetic‐environmental contributions to individual differences in neural activation in two prefrontal cortex (PFC) areas previously shown to be involved in sadness. No genetic effects were found for any area, individual environmental factors entirely accounting for individual variation in brain activation related to sadness. Sadness being the prevailing mood in depression, these findings may be of relevance to the etiology of childhood depressive disorders. Hum Brain Mapp 2007. © 2007 Wiley‐Liss, Inc.
The Histone Acetyltransferase PCAF Associates with Actin and hnRNP U for RNA Polymerase II Transcription

ABSTRACT Actin is a key regulator of RNA polymerase (pol) II transcription. In complex with specific hnRNPs, it has been proposed that actin functions to recruit pol II coactivators during the elongation of nascent transcripts. Here, we show by affinity chromatography, protein-protein interaction assays, and biochemical fractionation of nuclear extracts that the histone acetyltransferase (HAT) PCAF associates with actin and hnRNP U. PCAF and the nuclear actin-associated HAT activity detected in the DNase I-bound protein fraction could be released by disruption of the actin-hnRNP U complex. In addition, actin, hnRNP U, and PCAF were found to be associated with the Ser2/5- and Ser2-phosphorylated pol II carboxy-terminal domain construct. Chromatin and RNA immunoprecipitation assays demonstrated that actin, hnRNP U, and PCAF are present at the promoters and coding regions of constitutively expressed pol II genes and that they are associated with ribonucleoprotein complexes. Finally, disruption of the actin-hnRNP U interaction repressed bromouridine triphosphate incorporation in living cells, suggesting that actin and hnRNP U cooperate with PCAF in the regulation of pol II transcription elongation.
Feature sampling and partitioning for visual vocabulary generation on large action classification datasets

The recent trend in action recognition is towards larger datasets, an increasing number of action classes and larger visual vocabularies. State-of-the-art human action classification in challenging video data is currently based on a bag-of-visual-words pipeline in which space-time features are aggregated globally to form a histogram. The strategies chosen to sample features and construct a visual vocabulary are critical to performance, in fact often dominating performance. In this work we provide a critical evaluation of various approaches to building a vocabulary and show that good practises do have a significant impact. By subsampling and partitioning features strategically, we are able to achieve state-of-the-art results on 5 major action recognition datasets using relatively small visual vocabularies.
An Exploration of Future Patterns of the Contributions to OpenStreetMap and Development of a Contribution Index

OpenStreetMap (OSM) represents one of the most well‐known examples of a collaborative mapping project. Major research efforts have so far dealt with data quality analysis but the modality of OSM's evolution across space and time has barely been noted. This study aims to analyze spatio‐temporal patterns of contributions in OSM by proposing a contribution index (CI) in order to investigate the dynamism of OSM. The CI is based on a per cell analysis of the node quantity, interactivity, semantics, and attractivity (the ability to attract contributors). Additionally this research explores whether OSM has been constantly attracting new users and contributions or if OSM has experienced a decline in its ability to attract continued contributions. Using the Stuttgart region of Germany as a case study the empirical findings of the CI over time confirm that since 2007, OSM has been constantly attracting new users, who create new features, edit the existing spatial objects, and enrich them with attributes. This rate has been dramatically growing since 2011. The utilization of a Cellular Automata‐Markov (CA‐Markov) model provides evidence that by the end of 2016 and 2020, the rise of CI will spread out over the study area and only a few cells without OSM features will remain.
Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich’s ataxia

Friedreich’s ataxia (FRDA) is caused by biallelic expansion of GAA repeats leading to the transcriptional silencing of the frataxin (FXN) gene. The exact molecular mechanism of inhibition of FXN expression is unclear. Herein, we analyze the effects of hyperexpanded GAA repeats on transcription status and chromatin modifications proximal and distal to the GAA repeats. Using chromatin immunoprecipitation and quantitative PCR we detected significant changes in the chromatin landscape in FRDA cells relative to control cells downstream of the promoter, especially in the vicinity of the GAA tract. In this region, hyperexpanded GAAs induced a particular constellation of histone modifications typically associated with heterochromatin-like structures. Similar epigenetic changes were observed in GFP reporter construct containing 560 GAA repeats. Furthermore, we observed similar levels of FXN pre-mRNA at a region upstream of hyperexpanded GAA repeats in FRDA and control cells, indicating similar efficiency of transcription initiation. We also demonstrated that histone modifications associated with hyperexpanded GAA repeats are independent of initiation and progression of transcription. Our data provide strong evidence that FXN deficiency in FRDA patients results from a block of transition from initiation to a productive elongation of FXN transcription due to heterochromatin-like structures formed in the proximity of the hyperexpanded GAAs.
Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions

Purpose: Triple-negative breast cancer (TNBC) and ovarian cancer each comprise heterogeneous tumors, for which current therapies have little clinical benefit. Novel therapies that target and eradicate tumor-initiating cells (TIC) are needed to significantly improve survival. Experimental Design: A panel of well-annotated patient-derived xenografts (PDX) was established, and surface markers that enriched for TIC in specific tumor subtypes were empirically determined. The TICs were queried for overexpressed antigens, one of which was selected to be the target of an antibody–drug conjugate (ADC). The efficacy of the ADC was evaluated in 15 PDX models to generate hypotheses for patient stratification. Results: We herein identified E-cadherin (CD324) as a surface antigen able to reproducibly enrich for TIC in well-annotated, low-passage TNBC and ovarian cancer PDXs. Gene expression analysis of TIC led to the identification of Ephrin-A4 (EFNA4) as a prospective therapeutic target. An ADC comprising a humanized anti-EFNA4 monoclonal antibody conjugated to the DNA-damaging agent calicheamicin achieved sustained tumor regressions in both TNBC and ovarian cancer PDX in vivo. Non-claudin low TNBC tumors exhibited higher expression and more robust responses than other breast cancer subtypes, suggesting a specific translational application for tumor subclassification. Conclusions: These findings demonstrate the potential of PF-06647263 (anti–EFNA4-ADC) as a first-in-class compound designed to eradicate TIC. The use of well-annotated PDX for drug discovery enabled the identification of a novel TIC target, pharmacologic evaluation of the compound, and translational studies to inform clinical development. Clin Cancer Res; 21(18); 4165–73. ©2015 AACR.
Do Male White-Lipped Frogs Use Seismic Signals for Intraspecific Communication?

Abstract Modern frogs and toads possess a structurally unique saccule, endowing them with seismic sensitivity greater than that observed so far in any other group of terrestrial vertebrates. In synchrony with their advertisement calls, approximately half of the calling males of one frog species, the Puerto-Rican white-lipped frog (Leptodactylus albilabris), produce impulsive seismic signals (thumps). The spectral distribution of power in these seismic signals matches precisely the spectral sensitivity of the frog's saccule. The signals have sufficient amplitude to be sensed easily by the frog's saccule up to several meters from the source—well beyond the typical spacing when these frogs are calling in a group. This circumstantial evidence suggests that white-lipped frogs may use the seismic channel in intraspecific communication, possibly as an alternative to the airborne channel, which often is cluttered with noise and interference. Using the frog's vocalizations as our assay, we set out to test that pro.
Linear convergence of a modified Frank–Wolfe algorithm for computing minimum-volume enclosing ellipsoids

We show the linear convergence of a simple first-order algorithm for the minimum-volume enclosing ellipsoid problem and its dual, the D-optimal design problem of statistics. Using similar techniques, we show the linear convergence of the Frank–Wolfe algorithm with away steps applied to the simplex, under conditions different from those of Guélat and Marcotte. Computational tests confirm the attractive features of this method.
The Utility of Endoscopic Biopsies in Patients with Normal Upper Endoscopy

Background and Aims. Upper endoscopy is a valuable tool in the workup of gastrointestinal (GI) complaints. The purpose of this study is to determine cost and yield of taking biopsies in a normal upper GI tract. Methods. This is a retrospective study where all upper GI biopsies were identified between May 2012 and April 2013, at a tertiary care center. Clinical, procedural, and pathology reports were reviewed to identify patient demographics, procedure information, and pathology diagnosis. Results. Biopsies of the upper GI tract were taken in 1297 patients with normal upper endoscopies. In patients with normal upper endoscopy, 22% of esophageal, 44% of gastric, and 12% of duodenal biopsies were abnormal. The most frequent abnormality was reflux esophagitis in 16% of esophageal biopsies, chronic gastritis in 23% of gastric biopsies, and increased intraepithelial lymphocytes in 6% of duodenal biopsies. The additional cost for taking biopsies in a normal upper GI tract for a diagnosis of eosinophilic esophagitis was $2963 Canadian (CAD), H. pylori associated gastritis was $1404 CAD, and celiac disease was $3024 CAD. Conclusions. The yield of biopsy in normal upper endoscopy varied with location, but the additional expense can be costly and should be tailored to appropriate clinical situations.
Streptomyces venezuelae ISP5230 Maintains Excretion of Jadomycin upon Disruption of the MFS Transporter JadL Located within the Natural Product Biosynthetic Gene Cluster

JadL was identified as a Major Facilitator Superfamily (MFS) transporter (T.C. 2.A.1) through sequence homology. The protein is encoded by jadL, situated within the jadomycin biosynthetic gene cluster. JadL has, therefore, been assigned a putative role in host defense by exporting its probable substrates, the jadomycins, a family of secondary metabolites produced by Streptomyces venezuelae ISP5230. Herein, we evaluate this assumption through the construction and analysis of a jadL disrupted mutant, S. venezuelae VS678 (ΔjadL::aac(3)IV). Quantitative determination of jadomycin production with the jadL disrupted mutant did not show a significant decrease in production in comparison to the wildtype strain, as determined by HPLC and by tandem mass spectrometry. These results suggest that efflux of jadomycin occurs upon disruption of jadL, or that JadL is not involved in jadomycin efflux. Potentially, other transporters within S. venezuelae ISP5230 may adopt this role upon inactivation of JadL to export jadomycins.