Miracle-dz/UniFAR-FTUs huggingface dataset:
Striatal Dopamine D2/3 Receptor Availability in Treatment Resistant Depression

Several studies demonstrated improvement of depressive symptoms in treatment resistant depression (TRD) after administering dopamine agonists which suggest abnormal dopaminergic neurotransmission in TRD. However, the role of dopaminergic signaling through measurement of striatal dopamine D2/3 receptor (D2/3R) binding has not been investigated in TRD subjects. We used [123I]IBZM single photon emission computed tomography (SPECT) to investigate striatal D2/3R binding in TRD. We included 6 severe TRD patients, 11 severe TRD patients on antipsychotics (TRD AP group) and 15 matched healthy controls. Results showed no significant difference (p = 0.75) in striatal D2/3R availability was found between TRD patients and healthy controls. In the TRD AP group D2/3R availability was significantly decreased (reflecting occupancy of D2/3Rs by antipsychotics) relative to TRD patients and healthy controls (p<0.001) but there were no differences in clinical symptoms between TRD AP and TRD patients. This preliminary study therefore does not provide evidence for large differences in D2/3 availability in severe TRD patients and suggests this TRD subgroup is not characterized by altered dopaminergic transmission. Atypical antipsychotics appear to have no clinical benefit in severe TRD patients who remain depressed, despite their strong occupancy of D2/3Rs.
Arterial Carboxyhemoglobin Measurement Is Useful for Evaluating Pulmonary Inflammation in Subjects with Interstitial Lung Disease

Objective The arterial concentration of carboxyhemoglobin (CO-Hb) in subjects with inflammatory pulmonary disease is higher than that in healthy individuals. We retrospectively analyzed the relationship between the CO-Hb concentration and established markers of disease severity in subjects with interstitial lung disease (ILD). Methods The CO-Hb concentration was measured in subjects with newly diagnosed or untreated ILD and the relationships between the CO-Hb concentration and the serum biomarker levels, lung function, high-resolution CT (HRCT) findings, and the uptake in gallium-67 (67Ga) scintigraphy were evaluated. Results Eighty-one non-smoking subjects were studied (mean age, 67 years). Among these subjects, (A) 17 had stable idiopathic pulmonary fibrosis (IPF), (B) 9 had an acute exacerbation of IPF, (C) 44 had stable non-IPF, and (D) 11 had an exacerbation of non-IPF. The CO-Hb concentrations of these subjects were (A) 1.5±0.5%, (B) 2.1±0.5%, (C) 1.2±0.4%, and (D) 1.7±0.5%. The CO-Hb concentration was positively correlated with the serum levels of surfactant protein (SP)-A (r=0.38), SP-D (r=0.39), and the inflammation index (calculated from HRCT; r=0.57) and was negatively correlated with the partial pressure of oxygen in the arterial blood (r=-0.56) and the predicted diffusion capacity of carbon monoxide (r=-0.61). The CO-Hb concentrations in subjects with a negative heart sign on 67Ga scintigraphy were higher than those in subjects without a negative heart sign (1.4±0.5% vs. 1.1±0.3%, p=0.018). Conclusion The CO-Hb levels of subjects with ILD were increased, particularly during an exacerbation, and were correlated with the parameters that reflect pulmonary inflammation.
Razumikhin-type theorems for ISS of nonlinear delayed impulsive systems

In this paper we investigate the problem of input-to-state stability (ISS) of nonlinear delayed impulsive systems. Both the continuous dynamics and the discrete dynamics of nonlinear impulsive systems are subjected to external input. By virtue of the Razumikhin technique in combination with Lyapunov functions, we obtain some Razumikhin-type theorems that warrant input-to-state stability of nonlinear impulsive systems with time-delays. The Razumikhin-type input-to-state stability theorems cover the cases where the delayed continuous dynamics are input-to-state stable or destabilizing and the discrete dynamics are input-to-state stable or destabilizing, such that nonlinear delayed impulsive systems are able to retain input-to-state stability under certain conditions. The applicability of the derived Razumikhin-type theorems is illustrated by numerical results.
Screening for microsatellite instability target genes in colorectal cancers

Background: Defects in the DNA repair system lead to genetic instability because replication errors are not corrected. This type of genetic instability is a key event in the malignant progression of HNPCC and a subset of sporadic colon cancers and mutation rates are particularly high at short repetitive sequences. Somatic deletions of coding mononucleotide repeats have been detected, for example, in the TGFβRII and BAX genes, and recently many novel target genes for microsatellite instability (MSI) have been proposed. Novel target genes are likely to be discovered in the future. More data should be created on background mutation rates in MSI tumours to evaluate mutation rates observed in the candidate target genes. Methods: Mutation rates in 14 neutral intronic repeats were evaluated in MSI tumours. Bioinformatic searches combined with keywords related to cancer and tumour suppressor or CRC related gene homology were used to find new candidate MSI target genes. By comparison of mutation frequencies observed in intronic mononucleotide repeats versus exonic coding repeats of potential MSI target genes, the significance of the exonic mutations was estimated. Results: As expected, the length of an intronic mononucleotide repeat correlated positively with the number of slippages for both G/C and A/T repeats (p=0.0020 and p=0.0012, respectively). BRCA1, CtBP1, and Rb1 associated CtIP and other candidates were found in a bioinformatic search combined with keywords related to cancer. Sequencing showed a significantly increased mutation rate in the exonic A9 repeat of CtIP (25/109=22.9%) as compared with similar intronic repeats (p≤0.001). Conclusions: We propose a new candidate MSI target gene CtIP to be evaluated in further studies.
An SDN orchestrator for resources chaining in cloud data centers

The oversubscription of intra-Data Center links and the high volatility of Virtual Machine deployments require a flexible and agile control of the Data Center network infrastructure, possibly coordinated with computing and storage resources control. In this scenario, the Software-Defined Networking paradigm opens up new opportunities to design orchestrated resources control strategies able to meet the dynamically-changing traffic demands of instantiated Virtual Machines. This paper presents the architectural design of an SDN-based orchestrator for dynamic computing and communication resources chaining, able to assure better than best effort VMs data exchanges across Cloud Data Centers. Moreover, the paper evaluates a number of different chaining strategies able to dynamically compose proper pool of resources based on their variable load. Such strategies are compared against specific management objectives using both simulations and experiments showing their effectiveness in terms of resource usage and service provisioning rate.
Neural computations underlying action-based decision making in the human brain

Action-based decision making involves choices between different physical actions to obtain rewards. To make such decisions the brain needs to assign a value to each action and then compare them to make a choice. Using fMRI in human subjects, we found evidence for action-value signals in supplementary motor cortex. Separate brain regions, most prominently ventromedial prefrontal cortex, were involved in encoding the expected value of the action that was ultimately taken. These findings differentiate two main forms of value signals in the human brain: those relating to the value of each available action, likely reflecting signals that are a precursor of choice, and those corresponding to the expected value of the action that is subsequently chosen, and therefore reflecting the consequence of the decision process. Furthermore, we also found signals in the dorsomedial frontal cortex that resemble the output of a decision comparator, which implicates this region in the computation of the decision itself.
Ametropia among school children-A cross-sectional study in a sub-urban municipality in Ghana

Background: Uncorrected refractive error is a major disease burden among children around the world. Refractive error can lead to childhood blindness. When their vision suffers, children’s routine schoolwork and day to day activities also get affected. Methods: Children whose parents/guardians consented to the study and satisfied the inclusion criteria were taken through a battery of eye examinations. This included visual acuity measurement using a 6-metre Snellen chart, non-cycloplegic retinoscopy, subjective refraction, external ocular examination using a pentorch, anterior and posterior segment examination as well as fundus examination using a direct ophthalmoscope. The association between refractive error and socio-economic status (SES) of parents/guardians was also investigated. Results: A total of 208 children were studied. There were 101 males (48.6%) and 107 females (51.4%). Parents of 52.7% of the children studied were in the low SES level. The prevalence of refractive error was 30.29%. The commonest refractive error was myopia (22.6%), followed by astigmatism (5.3%) and then hyperopia (2.4%). Only 4 (6.3%) of the pupils with refractive error wore correction. The prevalence of refractive error appeared to increase with age and SES of parents. None of the parents/guardians of the children who wore correction was in the low SES group. Conclusion: The prevalence of uncorrected refractive error among the pupils was high. We recommend that periodic eye screening in school children should be carried out in such low income settings and public health programs on childhood refractive error should be increased in such settings. Correspondence to: Mohammed Abdul-Kabir, Department of Optometry and Visual Science, B9 COS Building, KNUST-Kumasi, Ghana, Tel: +233266307211; Fax: +233266307211; E-mail: kabir265@gmail.com
Impact of birth complications on breastfeeding duration: an internet survey.

AIM To explore reasons underlying cessation of breastfeeding in mothers with uncomplicated vaginal deliveries and those experiencing complications during childbirth. BACKGROUND Interventions during labour and childbirth can have a negative impact on breastfeeding. Explanations include adverse reactions to medication, delayed breastfeeding initiation, and disruption of the normal endocrinology of childbirth. However, reasons for breastfeeding cessation linked to birth experience have not been fully examined. Increasing breastfeeding duration and, consequently, improving infant and maternal health in the UK depend on understanding why women stop breastfeeding. DESIGN An exploratory cross-sectional survey. METHOD Between January-May 2009, 284 mothers attending community groups in Swansea, Wales, and mothers participating in online parenting forums, who initiated breastfeeding but discontinued before 6 months postpartum, reported their birth experience, including complications and reasons for breastfeeding cessation in an internet survey. RESULTS Mothers who experienced birth complications breastfed for a significantly shorter duration than those who did not. Specifically, caesarean deliveries, foetal distress, failure to progress, and postpartum haemorrhage were each associated with a shorter breastfeeding duration. Mothers who experienced complications were more likely to discontinue breastfeeding for reasons of pain and difficulty than mothers who did not experience complications, yet no difference was seen between groups for social reasons such as embarrassment or a lack of support. CONCLUSION Certain complications during labour may increase risk of specific physical difficulties with breastfeeding, possibly due to their association with medications received. Maternity health professionals should be alert to this possibility to offer enhanced attention and care to overcome these issues and prolong breastfeeding duration.
Defective Suppressor Function of Human CD4+ CD25+ Regulatory T Cells in Autoimmune Polyglandular Syndrome Type II

In autoimmune polyglandular syndromes (APS), several organ-specific autoimmune diseases are clustered. Although APS type I is caused by loss of central tolerance, the etiology of APS type II (APS-II) is currently unknown. However, in several murine models, depletion of CD4+ CD25+ regulatory T cells (Tregs) causes a syndrome resembling human APS-II with multiple endocrinopathies. Therefore, we hypothesized that loss of active suppression in the periphery could be a hallmark of this syndrome. Tregs from peripheral blood of APS-II, control patients with single autoimmune endocrinopathies, and normal healthy donors showed no differences in quantity (except for patients with isolated autoimmune diseases), in functionally important surface markers, or in apoptosis induced by growth factor withdrawal. Strikingly, APS-II Tregs were defective in their suppressive capacity. The defect was persistent and not due to responder cell resistance. These data provide novel insights into the pathogenesis of APS-II and possibly human autoimmunity in general.
Generality versus size in genetic programming

Genetic Programming (GP) uses variable size representations as programs. Size becomes an important and interesting emergent property of the structures evolved by GP. The size of programs can be both a controlling and a controlled factor in GP search. Size influences the efficiency of the search process and is related to the generality of solutions. This paper analyzes the size and generality issues in standard GP and GP using subroutines and addresses the question whether such an analysis can help control the search process. We relate the size, generalization and modularity issues for programs evolved to control an agent in a dynamic and non-deterministic environment, as exemplified by the Pac-Man game.
Mycoplasma pneumoniae and Its Role as a Human Pathogen

SUMMARY Mycoplasma pneumoniae is a unique bacterium that does not always receive the attention it merits considering the number of illnesses it causes and the degree of morbidity associated with it in both children and adults. Serious infections requiring hospitalization, while rare, occur in both adults and children and may involve multiple organ systems. The severity of disease appears to be related to the degree to which the host immune response reacts to the infection. Extrapulmonary complications involving all of the major organ systems can occur in association with M. pneumoniae infection as a result of direct invasion and/or autoimmune response. The extrapulmonary manifestations are sometimes of greater severity and clinical importance than the primary respiratory infection. Evidence for this organism's contributory role in chronic lung conditions such as asthma is accumulating. Effective management of M. pneumoniae infections can usually be achieved with macrolides, tetracyclines, or fluoroquinolones. As more is learned about the pathogenesis and immune response elicited by M. pneumoniae, improvement in methods for diagnosis and prevention of disease due to this organism may occur.
In-service training for academic librarians: a pilot programme for staff

Purpose – The purpose of this paper is to discuss the need for continuing professional development for librarians in academic libraries in general and at Rhodes University Library, South Africa, in particular. It aims to describe the planning, design, implementation and evaluation of a staff‐development and training pilot programme for professional librarians at Rhodes Library.Design/methodology/approach – A group of 15 librarians, drawn from the library staff complement, participated in an eight‐session training course developed by information services librarians. The course, which covered basic information‐finding skills using a variety of research databases and offered an introduction to concepts in twenty‐first century academic librarianship, was presented using course management software in a face‐to‐face environment and required homework exercises and the completion of a two‐hour final test.Findings – Results of the project demonstrated the urgent need for such development programmes for professiona.
Cardiovascular disease in HIV patients: from bench to bedside and backwards

HIV patients are exposed to a higher risk of adverse cardiovascular events, due to complex interactions between traditional risk factors and HIV infection itself in terms of ongoing endothelial dysfunctional immune activation/inflammation and increased risk of thrombosis. On the other hand, long-span antiretroviral therapy administration still raises questions on its long-term safety in an era in which life expectancy is becoming longer and longer while treatment of non-HIV-related serious events is increasingly raising concern. In this article, we will critically analyse the current knowledge of pathological and clinical aspects pertaining to the increased risk of cardiovascular events associated with HIV.
Effect of Salsalate on Insulin Action, Secretion, and Clearance in Nondiabetic, Insulin-Resistant Individuals: A Randomized, Placebo-Controlled Study

OBJECTIVE Salsalate treatment has been shown to improve glucose homeostasis, but the mechanism remains unclear. The aim of this study was to evaluate the effect of salsalate treatment on insulin action, secretion, and clearance rate in nondiabetic individuals with insulin resistance. RESEARCH DESIGN AND METHODS This was a randomized (2:1), single-blind, placebo-controlled study of salsalate (3.5 g daily for 4 weeks) in nondiabetic individuals with insulin resistance. All individuals had measurement of glucose tolerance (75-g oral glucose tolerance test), steady-state plasma glucose (SSPG; insulin suppression test), and insulin secretion and clearance rate (graded-glucose infusion test) before and after treatment. RESULTS Forty-one individuals were randomized to salsalate (n = 27) and placebo (n = 14). One individual from each group discontinued the study. Salsalate improved fasting (% mean change −7% [95% CI −10 to −14] vs. 1% [−3 to 5], P = 0.005) but not postprandial glucose concentration compared with placebo. Salsalate also lowered fasting triglyceride concentration (−25% [−34 to −15] vs. −6% [−26 to 14], P = 0.04). Salsalate had no effect on SSPG concentration or insulin secretion rate but significantly decreased insulin clearance rate compared with placebo (−23% [−30 to −16] vs. 3% [−10 to 15], P < 0.001). Salsalate was well tolerated, but four individuals needed a dose reduction due to symptoms. CONCLUSIONS Salsalate treatment in nondiabetic, insulin-resistant individuals improved fasting, but not postprandial, glucose and triglyceride concentration. These improvements were associated with a decrease in insulin clearance rate without change in insulin action or insulin secretion.
Molecular principles of human virus protein-protein interactions

MOTIVATION Viruses, from the human protein-protein interaction network perspective, target hubs, bottlenecks and interconnected nodes enriched in certain biological pathways. However, not much is known about the general characteristic features of the human proteins interacting with viral proteins (referred to as hVIPs) as well as the motifs and domains utilized by human-virus protein-protein interactions (referred to as Hu-Vir PPIs). RESULTS Our study has revealed that hVIPs are mostly disordered proteins, whereas viral proteins are mostly ordered proteins. Protein disorder in viral proteins and hVIPs varies from one subcellular location to another. In any given viral-human PPI pair, at least one of the two proteins is structurally disordered suggesting that disorder associated conformational flexibility as one of the characteristic features of virus-host interaction. Further analyses reveal that hVIPs are (i) slowly evolving proteins, (ii) associated with high centrality scores in human-PPI network, (iii) involved in multiple pathways, (iv) enriched in eukaryotic linear motifs (ELMs) associated with protein modification, degradation and regulatory processes, (v) associated with high number of splice variants and (vi) expressed abundantly across multiple tissues. These aforementioned findings suggest that conformational flexibility, spatial diversity, abundance and slow evolution are the characteristic features of the human proteins targeted by viral proteins. Hu-Vir PPIs are mostly mediated via domain-motif interactions (DMIs) where viral proteins employ motifs that mimic host ELMs to bind to domains in human proteins. DMIs are shared among viruses belonging to different families indicating a possible convergent evolution of these motifs to help viruses to adopt common strategies to subvert host cellular pathways. AVAILABILITY AND IMPLEMENTATION Hu-Vir PPI data, DDI and DMI data for human-virus PPI can be downloaded from http://cdfd.org. in/labpages/computational_biology_datasets. html. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Radial distribution and strong lensing statistics of satellite galaxies and substructure using high‐resolution ΛCDM hydrodynamical simulations

We analyse the number density and radial distribution of substructures and satellite galaxies using cosmological simulations that follow the gas dynamics of a baryonic component, including shock heating, radiative cooling and star formation within the hierarchical concordance Lambda cold dark matter model. We find that the dissipation of the baryons greatly enhances the survival of subhaloes, especially in the galaxy core, resulting in a radial distribution of satellite galaxies that closely follows the overall mass distribution. Hydrodynamical simulations are necessary to resolve the adiabatic contraction and dense cores of galaxies, resulting in a total number of satellites a factor of 2 larger than that found in pure dark matter simulation, in good agreement with the observed spatial distribution of satellite galaxies within galaxies and clusters. Convergence tests show that the cored distribution found by previous authors in pure N-body simulations was due to the physical overmerging of dark matter only structures. We proceed to use a ray-shooting technique in order to study the impact of these additional substructures on the number of violations of the cusp caustic magnification relation. We develop a new approach to try to disentangle the effect of substructures from the intrinsic discreteness of N-body simulations. Even with the increased number of substructures in the centres of galaxies, we are not able to reproduce the observed high numbers of discrepancies observed in the flux ratios of multiply lensed quasars.
Contribution of Type Ia and Type II Supernovae to Intracluster Medium Enrichment

The origin of the chemical composition of the intracluster medium (ICM) is discussed in this paper. In particular, the contribution from Type Ia supernovae (SNe Ia) to the ICM enrichment is demonstrated by adopting the fitting formulas that have been used in the analysis of the solar system abundances. Our analysis means that we can use the frequency of SNe Ia relative to SNe II as a better measure than MFe,SN Ia/MFe,total for estimating the contribution of SNe Ia. Moreover, the chemical compositions of ICMs are shown to be similar to that of the solar system abundances. We can also reproduce the sulfur/iron abundance ratio within a factor of 2, which means that the abundance problem of sulfur does not need to be emphasized too strongly. We need more precise observations to conclude whether ICMs really suffer a sulfur shortage problem or not.