Miracle-dz/UniFAR-FTUs huggingface dataset:
Properties of visual cells in the lateral eye of Limulus in situ

Excitatory properties of visual cells in the lateral eye of Limulus, investigated by optic nerve recordings in situ, differ significantly from the properties of cells in the classical, excised eye preparation. The differences suggest the possibility that two receptor mechanisms function in the eye in situ: one mechanism encodes low light intensities and the other responds to high intensities. The two mechanisms enable each ommatidium to respond over an intensity range of approximately 10 log units. This hypothesis was tested by measuring the increment threshold and the spectral sensitivity, by studying light and dark adaptation, and by analyzing the variability of the impulse discharge. Although the results do not conclusively identify two receptor mechanisms, they indicate that a process or a part of a process that functions in the eye in situ is abolished by excising the eye or cutting off its blood supply.
Prolonged Practice of a Simple Motor Task by Preferred and Nonpreferred Hands

After prolonged practice (1300 10-sec trials) the tapping speed of the nonpreferred hand reached that of the preferred hand on a simple finger-tapping task. Analysis of the intertap intervals showed the variability of the duration of intertap intervals was smaller for the preferred than for the nonpreferred hand; the difference was not affected by the prolonged practice for N = 1.
Journal of Cardiovascular Magnetic Resonance Open Access Cardiovascular Magnetic Resonance Findings in a Case of Danon Disease Case Presentation

Danon disease is a rare X-linked dominant lysosomal glycogen storage disease that can lead to severe ventricular hypertrophy and heart failure. We report a case of Danon disease with cardiac involvement evaluated with cardiovascular magnetic resonance, including late gadolinium enhancement and perfusion studies. A 19 year old male with no previous history of heart disease was admitted with rest dyspnoea, found to be due to acute heart failure. He had felt fatigued with progressive limitation of exercise tolerance over the preceding 3 months. Symptoms were exacerbated by an upper respiratory tract infection one month before hospitalization. The patient was treated with antibiotics without noticeable improvement. The patient's mother had died suddenly at the age of 44 with a dilated cardiomyopathy of unknown cause for which she had had a pacemaker implanted. On admission, the patient was cachectic with a body mass index of 17 and in poor general condition, with rest dysp-noea, tachypnoea of 30/minute and tachycardia of 130/ minute. His liver was enlarged, there was evidence of pulmonary oedema and a systolic murmur, maximal at the apex. Blood analysis showed elevated liver enzymes (aspartate aminotransferase 192 units/L; alanine aminotransferase 400 u/L and creatine kinase 510 u/L) and mildly elevated Troponin I and C-reactive protein levels. Chest X-ray confirmed pulmonary oedema and showed an enlarged heart shadow. Sinus tachycardia and left bundle branch block with QRS duration >200 ms were present on electrocardi-ogram. Echocardiography on admission revealed significantly enlarged left ventricle and both atria, severe hypertrophy of both ventricles muscle without left ventricular outflow tract (LVOT) obstruction. which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
On perturbations of singular complex analytic curves

Suppose $V$ is a singular complex analytic curve inside $\mathbb{C}^{2}$. We investigate when a singular or non-singular complex analytic curve $W$ inside $\mathbb{C}^{2}$ with sufficiently small Hausdorff distance $d_{H}(V, W)$ from $V$ must intersect $V$. We obtain a sufficient condition on $W$ which when satisfied gives an affirmative answer to our question. More precisely, we show the intersection is non-empty for any such $W$ that admits at most one non-normal crossing type discriminant point associated with some proper projection. As an application, we prove a special case of the higher-dimensional analog, and also a holomorphic multifunction analog of a result by Lyubich-Peters.
Leptin-Receptor Gene Transfer into the Arcuate Nucleus of Female Fatty Zucker Rats Using Recombinant Adeno-Associated Viral Vectors Stimulates the Hypothalamo-Pituitary-Gonadal Axis1

Abstract Fatty fa/fa Zucker rats with a missense mutation in the leptin receptor (OB-R) are obese and infertile with prolonged estrous cycles. To determine whether their reproductive deficits could be corrected by OB-R installation, we employed viral vectors to introduce the OB-R gene into either the arcuate nucleus (ARC) or the paraventricular nucleus (PVN) of the hypothalamus, sites of OB-R expression in wild-type rats. Recombinant adeno-associated viral (rAAV) vectors encoding the human leptin-receptor gene (rAAV-OB-Rb) were microinjected intraparenchymally to produce doxycycline-regulatable OB-R gene expression. Expression of the OB-R gene in the ARC and PVN was verified using reverse transcription-polymerase chain reaction. Expression of OB-R in the ARC, but not in the PVN, resulted in normalization of estrous cycle length, increased ovarian follicular development, and decreased serum progesterone levels. Compared to saline-injected rats, hypothalamic expression of neuropeptide Y (NPY) and pro-opiomelanocortin were decreased in ARC rAAV-OB-Rb-injected rats. Parallel decreases were noted in NPY and β-endorphin (β-END) concentrations in the hypothalamus, whereas luteinizing hormone-releasing hormone (LHRH) levels increased. These studies showed that rAAV vectors can be successfully used to install functional OB-R in the hypothalamus for extended periods. The resultant stimulation of the hypothalamo-pituitary-gonadal (HPG) axis in ARC-injected rats was probably brought about by the observed decreases in NPY and β-END, which inhibit hypothalamic LHRH. Because these changes were seen in ARC-injected, but not in PVN-injected, rats, the results suggest that the ARC may be the primary site where leptin acts to regulate the HPG axis.
EFFECT OF S-ADENOSYLMETHIONINE ( SAME ) IN GENTAMICIN INDUCED NEPHROTOXICITY IN RATS

Objectives: Gentamicin nephrotoxicity is a common clinical situation in patients who receive it for a longer time period. The objective of the present study is to assess the effect of SAMe (S –Adenosyl Methionine) a precursor of Glutathione (endogenous antioxidant) in gentamicin induced nephrotoxicity in rats, by measuring serum urea, serum creatinine and histopathological analysis. Methods: Three groups (n=6) of Sprague Dawley rats weighing around 200-250 grams were used in the study. First group received normal saline (0.9%) 1 ml intramuscular (i.m), for 5 days, second group received 80m/kg of gentamicin i.m, for 5 days and the last group received 80mg/kg of gentamicin i.m and SAMe 5mg/kg intraperitoneal for 5 days. 24 hrs after the last injection, the rats were anaesthetized and blood was collected by cardiac puncture and sent for estimating serum urea and creatinine. The kidneys were dissected out and sent for histopathological analysis and were graded for percentage change of tubular necrosis. The results of the study were based on Kruskal Wallis test for among the groups and Mann Whitney U test for between the two groups. The measure of central tendency used for analysis was median. Results: The results of the study has shown that the group which had used SAMe + gentamicin had a slightly greater urea and creatinine, compared to gentamicin alone (p=0.630, 0.626) and saline alone group (p=0.335, 0.217), even though it was not statistically significant. Even among the groups, there was no statistical significance (p=0.279, 0.335). Similarly in the histopathological analysis, there was equivocal findings with respect to proximal tubular necrosis in both gentamicin alone and SAMe + gentamicin group. Conclusions: The results from the present study indicate that SAMe does not improve the nephrotoxicity caused by gentamicin, when assessed with serum urea, serum creatinine and histopathology.
The Influence of Compensation and Work Environment on Employee Performance at the BAPPEDA (Regional Development Planning Agency) Office of Bengkulu Province

The purpose of this study is to examine the impact of salary and work environment on employee performance in the Bengkulu Province BAPPEDA (Regional Development Planning Agency) Office. This study relied on primary data in the form of a questionnaire delivered to the research population. Employee performance is the dependent variable. Compensation and work environment are the independent factors considered. This study employs quantitative tools and a survey strategy. The research population consisted of 106 BAPPEDA personnel from Bengkulu Province. Purposive sampling was used to choose the research sample of 80 persons. With the assistance of SmartPLS, the data processing approach employs Structural Equation Modeling (SEM) analysis. The research results found that compensation and work environment have a significant effect on employee performance. This means that by providing appropriate compensation and a good work environment, employee performance at the BAPPEDA office can be improved.
Congestive Heart Failure Due to Systolic Dysfunction: The Cinderella of Cardiovascular Management in Dialysis Patients

Cardiac disease is common in dialysis patients. Survival is poorest in the subgroup with systolic dysfunction (pump failure). Audits show that cardiovascular management of dialysis patients in general, and treatment of congestive heart failure (CHF) specifically, is generally not in agreement with recommendations based on evidence obtained from controlled trials, admittedly in nonrenal patients. The pathophysiology underlying CHF and the rationale underlying interventions are discussed in an effort to heighten awareness of this important clinical problem in the dialysis community.
Characterization of Matriptase Expression in Normal Human Tissues

Matriptase is a type II transmembrane serine protease that has been implicated in the progression of epithelium-derived tumors. The role of this protease in the biology of normal epithelial cells remains to be elucidated. Matriptase mRNA has been detected by Northern analysis in tissues rich in epithelial cells, and the protein is expressed in vivo in normal and cancerous breast, ovarian, and colon tissues. However, a systematic analysis of the distribution of matriptase protein and mRNA in normal human tissues rich in epithelium has not been reported. In this study we characterized the expression of the protease in a wide variety of normal human tissues using a tissue microarray and whole tissue specimens. Significant immunoreactivity and mRNA expression were detected in the epithelial components of most epithelium-containing tissues. Matriptase expression was found in all types of epithelium, including columnar, pseudostratified columnar, cuboidal, and squamous. Distinct spatial distributions of reactivity were observed in the microanatomy of certain tissues, however. This suggests that although matriptase is broadly expressed among many types of epithelial cells, its activity within a tissue may be regulated in part at the protein and mRNA levels during the differentiation of selected epithelia.
Evaluation of the fidelity of an interactive face-to-face educational intervention to improve general practitioner management of back pain

Objectives Implementation intervention effects can only be fully realised and understood if they are faithfully delivered. However the evaluation of implementation intervention fidelity is not commonly undertaken. The IMPLEMENT intervention was designed to improve the management of low back pain by general medical practitioners. It consisted of a two-session interactive workshop, including didactic presentations and small group discussions by trained facilitators. This study aimed to evaluate the fidelity of the IMPLEMENT intervention by assessing: (1) observed facilitator adherence to planned behaviour change techniques (BCTs); (2) comparison of observed and self-reported adherence to planned BCTs and (3) variation across different facilitators and different BCTs. Design The study compared planned and actual, and observed versus self-assessed delivery of BCTs during the IMPLEMENT workshops. Method Workshop sessions were audiorecorded and transcribed verbatim. Observed adherence of facilitators to the planned intervention was assessed by analysing the workshop transcripts in terms of BCTs delivered. Self-reported adherence was measured using a checklist completed at the end of each workshop session and was compared with the ‘gold standard’ of observed adherence using sensitivity and specificity analyses. Results The overall observed adherence to planned BCTs was 79%, representing moderate-to-high intervention fidelity. There was no significant difference in adherence to BCTs between the facilitators. Sensitivity of self-reported adherence was 95% (95% CI 88 to 98) and specificity was 30% (95% CI 11 to 60). Conclusions The findings suggest that the IMPLEMENT intervention was delivered with high levels of adherence to the planned intervention protocol. Trial registration number The IMPLEMENT trial was registered in the Australian New Zealand Clinical Trials Registry, ACTRN012606000098538 (http://www.anzctr.org.au/trial_view.aspx? ID=1162).
An Optimal Game Theoretical Framework for Mobility Aware Routing in Mobile Ad hoc Networks

Selfish behaviors are common in self-organized Mobile Ad hoc Networks (MANETs) where nodes belong to different authorities. Since cooperation of nodes is essential for routing protocols, various methods have been proposed to stimulate cooperation among selfish nodes. In order to provide sufficient incentives, most of these methods pay nodes a premium over their actual costs of participation. However, they lead to considerably large overpayments. Moreover, existing methods ignore mobility of nodes, for simplicity. However, owing to the mobile nature of MANETs, this assumption seems unrealistic. In this paper, we propose an optimal game theoretical framework to ensure the proper cooperation in mobility aware routing for MANETs. The proposed method is based on the multi-dimensional optimal auctions which allows us to consider path durations, in addition to the route costs. Path duration is a metric that best reflects changes in topology caused by mobility of nodes and, it is widely used in mobility aware routing protocols. Furthermore, the proposed mechanism is optimalin that it minimizes the total expected payments. We provide theoretical analysis to support our claims. In addition, simulation results show significant improvements in terms of payments compared to the most popular existing methods.
The Cyclical Behavior of Equilibrium Unemployment and Vacancies with Worker Heterogeneity ∗

In this paper, we extend the basic Mortensen-Pissarides search and matching model along two dimensions. First, we allow for ex-ante heterogeneity between workers. Second, two technology shocks, neutral and investment-specific, are the driving forces of the economy. Specifically, we integrate the framework of Krusell, Ohanian, Ŕıos-Rull, and Violante (2000) a production function with capital-skill complementarity and two skill-groups into a business-cycle search and matching model. We calibrate the model extending the approach in Hagedorn and Manovskii (2006) and find that the model accounts well for the cyclical behavior of labor market variables in the aggregate and for each demographic group. We show that the response of unemployment to changes in taxes or unemployment insurance benefits is substantially reduced in the model with worker heterogeneity. JEL Classification: E24, E32, J41, J63, J64
Illegal Drug Use and Labor Supply

This paper investigates the relationship between labor supply and the consumption of marijuana and cocaine using data from the National Longitudinal Survey of Youth. Previous studies have yielded mixed evidence but have used potentially inadequate measures to account for the simultaneity between drug consumption and labor supply. I implement an instrumental variable procedure that utilizes a set of natural exogenous identifying variables for drug use, including regional cocaine prices and indicators of state marijuana decriminalization, and verify its validity with the relevant specification tests. Results indicate a substantial negative relationship between drug use and both employment and hours worked in both 1984 and 1988 that is always significant for males and sometimes significant for females. Hausman tests reveal that OLS estimates are biased down in magnitude, thus demonstrating the importance of controlling for simultaneity.
A General Theory for SIR Balancing

We study the problem of maximizing the minimum signal-to-interference ratio (SIR) in a multiuser system with an adaptive receive strategy. The interference of each user is modelled by an axiomatic framework, which reflects the interaction between the propagation channel, the power allocation, and the receive strategy used for interference mitigation. Assuming that there is a one-to-one mapping between the QoS and the signal-to-interference ratio (SIR), the feasible QoS region is completely characterized by the max-min SIR balancing problem. In the first part of the paper, we derive fundamental properties of this problem for the most general case, when interference is modelled with an axiomatic framework. In the second part, we show more specific properties for interference functions based on a nonnegative coupling matrix. The principal aim of this paper is to provide a deeper understanding of the interaction between power allocation and interference mitigation strategies. We show how the proposed axiomatic approach is related to the matrix-based theory.
Imaging and time reversal in random media

We present a general method for estimating the location of small, well-separated scatterers in a randomly inhomogeneous environment using an active sensor array. The main features of this method are (i) an arrival time analysis (ATA) of the echo received from the scatterers, (ii) a singular value decomposition of the array response matrix in the frequency domain, and (iii) the construction of an objective function in the time domain that is statistically stable and peaks on the scatterers. By statistically stable we mean here that the objective function is self-averaging over individual realizations of the medium. This is a new approach to array imaging that is motivated by time reversal in random media, analysed in detail previously. It combines features from seismic imaging, like ATA, with frequency-domain signal subspace methodology like multiple signal classification. We illustrate the theory with numerical simulations for ultrasound.
INTERNAL MECHANISM OF CORRELATION BETWEEN ANGIOTENSIN II GENE AND SERUM ADIPONECTIN LEVEL IN PATIENTS WITH CEREBROVASCULAR COMPLICATIONS OF H-TYPE HYPERTENSION

Background: The study aimed to explore the correlation between the angiotensin II (Ang II) gene and serum adiponectin expression in patients with cerebrovascular complications of H-type hypertension (HH) and its mechanism. Methods: A total of 50 cases of outpatient patients in Tianjin Fourth Central Hospital were recruited from January 2022 to June 2023 and rolled into three groups according to their blood pressure and basic information, namely the HH cerebrovascular complications group, the non-H-type hypertension (NHH) group, and the healthy control (HC) group. Peripheral blood samples were taken; one sample was utilized to test for the Ang II gene and the methylation of Ang II, and the other sample was utilized to measure serum adiponectin levels to analyze the relationship between serum adiponectin level and Ang II in patients with cerebrovascular complications of HH. Results: The ratio of male to female was 8:7 in the group of cerebrovascular complications of HH, and mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 167
The regulator gene phoB mediates phosphate stress‐controlled synthesis of the membrane lipid diacylglyceryl‐N,N,N‐trimethylhomoserine in Rhizobium (Sinorhizobium) meliloti

Bacteria react to phosphate starvation by activating genes involved in the transport and assimilation of phosphate as well as other phosphorous compounds. Some soil bacteria have evolved an additional mechanism for saving phosphorus. Under phosphate‐limiting conditions, they replace their membrane phospholipids by lipids not containing phosphorus. Here, we show that the membrane lipid pattern of the free‐living microsymbiotic bacterium Rhizobium (Sinorhizobium) meliloti is altered at low phosphate concentrations. When phosphate is growth limiting, an increase in sulpholipids, ornithine lipids and the de novo synthesis of diacylglyceryl trimethylhomoserine (DGTS) lipids is observed. Rhizobium meliloti phoCDET mutants, deficient in phosphate uptake, synthesize DGTS constitutively at low or high medium phosphate concentrations, suggesting that reduced transport of phosphorus sources to the cytoplasm causes induction of DGTS biosynthesis. Rhizobium meliloti phoU or phoB mutants are unable to form DGTS at low or high phosphate concentrations. However, the functional complementation of phoU or phoB mutants with the phoB gene demonstrates that, of the two genes, only intact phoB is required for the biosynthesis of the membrane lipid DGTS.
On Fractional Neutral Integro-differential Systems with State-dependent Delay in Banach Spaces

Based on concepts for semigroups, fractional calculus, resolvent operator and Banach contraction principle, this manuscript is principally involved with existence results for fractional neutral integro-differential systems with state-dependent delay in Banach spaces. To acquire the main results, our working concepts are that the functions deciding the equation fulfill certain Lipschitz conditions of local type which is similar to the hypotheses [1]. Finally an examples are additionally offered to exhibit the achieved hypotheses.
Botulinum Toxin for Relief of Bilateral Abductor Paralysis of the Larynx: Histologic Study in an Animal Model

We previously reported the effectiveness of botulinum toxin injections in the cricothyroid muscle under electromyographic guidance for lateralization of the true vocal cord in the mongrel dog. These additional experiments were performed to substantiate the effectiveness of botulinum toxin injections in laryngeal muscle to overcome airway obstruction produced by bilateral abductor vocal cord paralysis. A predetermined aliquot of the toxin was injected into the cricothyroid muscle of ten dogs, the duration of its effectiveness was noted, and repeated injections were given the animals. Biopsies of the injected muscles were obtained in three of the animals for routine histologic and electron microscopic studies. The effects of the toxin were recorded by cinelaryngoscopy and videotape documentation. In all the dogs, the true vocal cord was lateralized effectively and there was no morbidity, dysphagia, aspiration, or deaths. This study also confirms that the effects of the toxin in the canine larynx are spontaneously reversed and that multiple injections do not cause irreparable damage to the laryngeal muscles.