Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety and efficacy of peramivir for influenza treatment

Objective This report presents a review of the efficacy and safety of peramivir, a neuraminidase inhibitor that was granted Emergency Use Authorization by the US Food and Drug Administration (FDA) from October 23, 2009 to June 23, 2010 during the 2009 H1N1 pandemic. Methods Literature was accessed via PubMed (January 2000–April 2014) using several search terms: peramivir; BCX-1812; RWJ 270201; H1N1, influenza; antivirals; and neuraminidase inhibitors. The peramivir manufacturers, Shionogi and Co Ltd and BioCryst Pharmaceuticals, were contacted to obtain unpublished data and information presented at recent scientific meetings. Information was obtained from the Centers for Disease Control and Prevention (CDC) and from US FDA websites. English-language and Japanese-language reports in the literature were reviewed and selected based on relevance, along with information from the CDC, US FDA, and the drug manufacturers. Results We obtained eleven clinical trial reports of intravenous peramivir, two of which described comparisons with oseltamivir. Seven of nine other recently reported published studies was a dose–response study. Clinical reports of critically ill patients and pediatric patients infected with pandemic H1N1 described that early treatment significantly decreased mortality. Peramivir administered at 300 mg once daily in adult patients with influenza significantly reduces the time to alleviation of symptoms or fever compared to placebo. It is likely to be as effective as other neuraminidase inhibitors. Conclusion Although peramivir shows efficacy for the treatment of seasonal and pH1N1 influenza, it has not received US FDA approval. Peramivir is used safely and efficiently in hospitalized adult and pediatric patients with suspected or laboratory-confirmed influenza. Peramivir might be a beneficial alternative antiviral treatment for many patients, including those unable to receive inhaled or oral neuraminidase inhibitors, or those requiring nonintravenous drug delivery.
Environmental forcing on life history strategies: Evidence for multi-trophic level responses at ocean basin scales

Variation in life history traits of organisms is thought to reflect adaptations to environmental forcing occurring from bottom-up and top-down processes. Such variation occurs not only among, but also within species, indicating demographic plasticity in response to environmental conditions. From a broad literature review, we present evidence for ocean basinand large marine ecosystem-scale variation in intra-specific life history traits, with similar responses occurring among trophic levels from relatively short-lived secondary producers to very long-lived apex predators. Between North Atlantic and North Pacific Ocean basins, for example, species in the Eastern Pacific exhibited either later maturation, lower fecundity, and/or greater annual survival than conspecifics in the Western Atlantic. Parallel variations in life histories among trophic levels also occur in adjacent seas and between eastern vs. western ocean boundaries. For example, zooplankton and seabird species in cooler Barents Sea waters exhibit lower fecundity or greater annual survival than conspecifics in the Northeast Atlantic. Sea turtles exhibit a larger size and a greater reproductive output in the Western Pacific vs. Eastern Pacific. These examples provide evidence for food-web-wide modifications in life history strategies in response to environmental forcing. We hypothesize that such dichotomies result from frequency and amplitude shifts in resource availability over varying temporal and spatial scales. We review data that supports three primary mechanisms by which environmental forcing affects life history strategies: (1) food-web structure; (2) climate variability affecting the quantity and seasonality of primary productivity; (3) bottom-up vs. top-down forcing. These proposed mechanisms provide a framework for comparisons of ecosystem function among oceanic regions (or regimes) and are essential in modeling ecosystem response to climate change, as well as for creating dynamic ecosystem-based marine conservation strategies. 2009 Elsevier Ltd. All rights reserved.
Conventional signalling acts and conversation (extended version)

This article aims to provide foundations for a new approach to Agent Communication Languages (ACLs). First, we present the theory of signalling acts. In contrast to current approaches to communication, this account is neither intention-based nor committment-based, but conventionbased. Next, we explore ways of embedding that theory within an account of conversation. We move here from an account of the basic types of communicative act (the statics of communication) to an account of their role in sequences of exchanges in communicative interaction (the dynamics of communication). Finally, we apply the framework to the analysis of conversational protocols such as the English auction protocol. We propose to give a compact expression of conversation protocols by means of a formula of the object-language. We also use this kind of representation to provide the basis for a procedure for keeping a record of the conventional effects achieved in a conversation.
Placental invasiveness and brain–body allometry in eutherian mammals

Brain growth is a key trait in the evolution of mammalian life history. Brain development should be mediated by placentation, which determines patterns of resource transfer from mothers to fetal offspring. Eutherian placentation varies in the extent to which a maternal barrier separates fetal tissues from maternal blood. We demonstrate here that more invasive forms of placentation are associated with substantially steeper brain–body allometry, faster prenatal brain growth and slower prenatal body growth. On the basis of the physiological literature we suggest a simple mechanism for these differences: in species with invasive placentation, where the placenta is bathed directly in maternal blood, fatty acids essential for brain development can be readily extracted by the fetus, but in species with less invasive placentation they must be synthesized by the fetus. Hence, with regard to brain–body allometry and prenatal growth patterns, eutherian mammals are structured into distinct groups differing in placental invasiveness.
Identification and Characterization of a Repeat-in-Toxin Gene Cluster in Vibrio anguillarum

ABSTRACT Vibrio anguillarum is the causative agent of vibriosis in fish. Hemolysins of V. anguillarum have been considered virulence factors during infection. One hemolysin gene, vah1, has been previously identified but does not account for all hemolytic activity. The mini-Tn10Km mutagenesis performed with a vah1 mutant resulted in a hemolysin-negative mutant. The region surrounding the mutation was cloned and sequenced, revealing a putative rtx operon with six genes (rtxACHBDE), where rtxA encodes an exotoxin, rtxC encodes an RtxA activator, rtxH encodes a conserved hypothetical protein, and rtxBDE encode the ABC transporters. Single mutations in rtx genes did not result in a hemolysin-negative phenotype. However, strains containing a mutation in vah1 and a mutation in an rtx gene resulted in a hemolysin-negative mutant, demonstrating that the rtx operon is a second hemolysin gene cluster in V. anguillarum M93Sm. Reverse transcription-PCR analysis revealed that the rtxC and rtxA genes are cotranscribed, as are the rtxBDE genes. Additionally, Vah1 and RtxA each have cytotoxic activity against Atlantic salmon kidney (ASK) cells. Single mutations in vah1 or rtxA attenuate the cytotoxicity of V. anguillarum M93Sm. A vah1 rtxA double mutant is no longer cytotoxic. Moreover, Vah1 and RtxA each have a distinct cytotoxic effect on ASK cells, Vah1 causes cell vacuolation, and RtxA causes cell rounding. Finally, wild-type and mutant strains were tested for virulence in juvenile Atlantic salmon. Only strains containing an rtxA mutation had reduced virulence, suggesting that RtxA is a major virulence factor for V. anguillarum.
Investigation of deep neural networks (DNN) for large vocabulary continuous speech recognition: Why DNN surpasses GMMS in acoustic modeling

Recently, it has been reported that context-dependent deep neural network (DNN) has achieved some unprecedented gains in many challenging ASR tasks, including the well-known Switchboard task. In this paper, we first investigate DNN for several large vocabulary speech recognition tasks. Our results have confirmed that DNN can consistently achieve about 25-30% relative error reduction over the best discriminatively trained GMMs even in some ASR tasks with up to 700 hours of training data. Next, we have conducted a series of experiments to study where the unprecedented gain of DNN comes from. Our experiments show the gain of DNN is almost entirely attributed to DNN's feature vectors that are concatenated from several consecutive speech frames within a relatively long context window. At last, we have proposed a few ideas to reconfigure the DNN input features, such as using logarithm spectrum features or VTLN normalized features in DNN. Our results have shown that each of these methods yields over 3% relative error reduction over the traditional MFCC or PLP features in DNN.
Normal and abnormal category-effects in visual object recognition: A legacy of Glyn W. Humphreys

ABSTRACT Are all categories of objects recognized in the same manner visually? Evidence from neuropsychology suggests they are not, as some brain injured patients are more impaired in recognizing natural objects than artefacts while others show the opposite impairment. In an attempt to explain category-specific deficits for natural objects Glyn Humphreys and colleagues suggested that natural objects are harder to perceptually differentiate than artefacts because natural objects are more structurally similar than artefacts. This explanation was proposed in the context of the Cascade model of visual object naming. While this model has been successful in accounting for a number of observations concerning category-specificity in both patients with brain injury and normal subjects, it has also become clear that there are many important aspects of category-specificity that the model cannot accommodate. These limitations have led to the development of a new model of category-effects at pre-semantic stages in visual object processing, which can be considered a further development of the Cascade model: the Pre-semantic Account of Category-Effects (PACE). Here I give a slightly historical, but primarily integrative, account of this development including recent studies which address important aspects of both the Cascade and the PACE models.
Interdisciplinary Journal of Information, Knowledge, and Management a Methodology for Increasing Business Process Maturity in Public Sector

Non-profit organizations such as public sector organizations have some specifics, which make renovation projects significantly different. It is clear that radical changes in the execution of business processes and in the organizational structures are not suitable for the public sector because they are not possible for many, also political, reasons. A business process change in public sector mostly means unification of business processes, automation of some activities and elimination of some unnecessary ones. Organizational changes are achievable only to a certain limit. Therefore classic business process renovation methodologies have to be adapted. The proposed methodology that is presented in the paper has been successfully applied in a process change project at one of the Slovene Ministries, which is presented as a case study. Activities, techniques, and tools are proposed for each of the six traditional business process change project's stages. Problems and topics to which special attention has to be paid are also discussed.
Magnetic Pseudodifferential Operators with Coefficients in $C^*$-Algebras

In previous articles, a magnetic pseudodifferential calculus and a family of C*-algebras associated with twisted dynamical systems were introduced and the connections between them have been established. We extend this formalism to symbol classes of H\"ormander type with an x-behavior modelized by an abelian C*-algebra. Some of these classes generate C*-algebras associated with the twisted dynamical system. We show the relevance of these classes to the spectral analysis of pseudodifferential operators with anisotropic symbols and magnetic fields.
When Distance Mattered: Geographic Scale and the Development of European Representative Assemblies

Scholars investigating European state development have long placed a heavy emphasis on the role played by representative institutions. The presence of an active representative assembly, it is argued, allowed citizens and rulers to contract over raising revenue and accessing credit. It may also have had implications for economic growth. These arguments have in turn been used to draw broad implications about the causal effect of analogous institutions in other places and during other time periods. But if assemblies had such clear efficiency benefits, why did they not become a universal phenomenon in Europe prior to the nineteenth century? I argue that in an era of costly communications and transport, an intensive form of political representative was much easier to sustain in geographically compact polities. This simple fact had important implications for the pattern of European state formation, and it may provide one reason why small states were able to survive despite threats from much larger neighbors. I test several relevant hypotheses using an original data set that provides the first broad view of European representative institutions in the medieval and early modern eras. I combine this with a geographic information system data set of state boundaries and populations in Europe between 1250 and 1750. The results suggest a strong effect of geographic scale on the format of political representation. The broader implication of this result is to provide a reminder that if institutions help solve contracting problems, ultimately, the maintenance of institutions may itself depend on ongoing transactions costs.
Musical Interactions: Girls Who Like and Use Rap Music for Empowerment

Abstract This paper builds upon a new era of research seeking to understand variability in how desirable outcomes result from engaging rap music as a health enhancing artifact. More specifically, the study explores the music mediated pathways to individual and community well-being. The study emphasizes female music engagement. Quantitative methods are used to examine listening habits and preferences associated with empowering rap music engagement among a female sample of 202 university students using an a priori established path analysis model. Results echo prior research that suggests the functional value of music in helping to define the self independently and articulate one’s social identity within the context of community (Dixon, Zhang, & Conrad, 2009; Hill, 2009; Travis & Bowman, 2012). Specifically, results suggest that among females in this sample, (a) their appropriation of rap music can be empowering, (b) specific factors play a significant role in determining the difference between females that feel more or less empowered from their interactions with rap music, and (c) female listeners were more likely to appropriate rap music for personal and community growth if it was their favorite music type, if they listened often, and if they tended to listen alone more often than with friends. These research findings offer promising routes for more in depth qualitative analysis to help uncover the nuances of preferred engagement strategies and to help define the subjective lived experiences that lead to feeling empowered by music to act toward positive change for oneself and others. Practical results indicate the possibility for gender-specific education, therapeutic or empowerment-based programs that utilize rap music as a rubric.
The articulatory and acoustic characteristics of Polish sibilants and their consequences for diachronic change

The study is concerned with the relative synchronic stability of three contrastive sibilant fricatives /s ʂ ɕ/ in Polish. Tongue movement data were collected from nine first-language Polish speakers producing symmetrical real and non-word CVCV sequences in three vowel contexts. A Gaussian model was used to classify the sibilants from spectral information in the noise and from formant frequencies at vowel onset. The physiological analysis showed an almost complete separation between /s ʂ ɕ/ on tongue-tip parameters. The acoustic analysis showed that the greater energy at higher frequencies distinguished /s/ in the fricative noise from the other two sibilant categories. The most salient information at vowel onset was for /ɕ/, which also had a strong palatalizing effect on the following vowel. Whereas either the noise or vowel onset was largely sufficient for the identification of /s ɕ/ respectively, both sets of cues were necessary to separate /ʂ/ from /s ɕ/. The greater synchronic instability of /ʂ/ may derive from its high articulatory complexity coupled with its comparatively low acoustic salience. The data also suggest that the relatively late stage of /ʂ/ acquisition by children may come about because of the weak acoustic information in the vowel for its distinction from /s/.
Methanotrophy within the water column of a large meromictic tropical lake (Lake Kivu, East Africa)

Abstract. The permanently stratified Lake Kivu is one of the largest freshwater reservoirs of dissolved methane (CH4) on Earth. Yet CH4 emissions from its surface to the atmosphere have been estimated to be 2 orders of magnitude lower than the CH4 upward flux to the mixed layer, suggesting that microbial CH4 oxidation is an important process within the water column. A combination of natural abundance stable carbon isotope analysis (δ13C) of several carbon pools and 13CH4-labelling experiments was carried out during the rainy and dry season to quantify (i) the contribution of CH4-derived carbon to the biomass, (ii) methanotrophic bacterial production (MBP), and (iii) methanotrophic bacterial growth efficiency (MBGE), defined as the ratio between MBP and gross CH4 oxidation. We also investigated the distribution and the δ13C of specific phospholipid fatty acids (PLFAs), used as biomarkers for aerobic methanotrophs. Maximal MBP rates were measured in the oxycline, suggesting that CH4 oxidation was mainly driven by oxic processes. Moreover, our data revealed that methanotrophic organisms in the water column oxidized most of the upward flux of CH4, and that a significant amount of CH4-derived carbon was incorporated into the microbial biomass in the oxycline. The MBGE was variable (2–50%) and negatively related to CH4 : O2 molar ratios. Thus, a comparatively smaller fraction of CH4-derived carbon was incorporated into the cellular biomass in deeper waters, at the bottom of the oxycline where oxygen was scarce. The aerobic methanotrophic community was clearly dominated by type I methanotrophs and no evidence was found for an active involvement of type II methanotrophs in CH4 oxidation in Lake Kivu, based on fatty acids analyses. Vertically integrated over the water column, the MBP was equivalent to 16–60% of the average phytoplankton particulate primary production. This relatively high magnitude of MBP, and the substantial contribution of CH4-derived carbon to the overall biomass in the oxycline, suggest that methanotrophic bacteria could potentially sustain a significant fraction of the pelagic food web in the deep, meromictic Lake Kivu.
Cancer Management and Research Dovepress Microrna Function and Dysregulation in Bone Tumors: the Evidence to Date

Micro ribonucleic acids (miRNAs) are small non-coding RNA segments that have a role in the regulation of normal cellular development and proliferation including normal osteogenesis. They exert their effects through inhibition of specific target genes at the post-transcriptional level. Many miRNAs have altered expression levels in cancer (either increased or decreased depending on the specific miRNA). Altered miRNA expression profiles have been identified in several malignancies including primary bone tumors such as osteosarcoma and Ewing's sarcoma. It is thought that they may function as tumor suppressor genes or oncogenes and hence when dysregulated contribute to the initiation and progression of malignancy. miRNAs are also thought to have a role in the development of bone metastases in other malignancies. In addition, evidence increasingly suggests that miRNAs may play a part in determining the response to chemotherapy in the treatment of osteosarcoma. These molecules are readily detectable in tissues, both fresh and formalin fixed paraffin embedded and, more recently, in blood. Although there are fewer published studies regarding circulating miRNA profiles, they appear to reflect changes in tissue expression. Thus miRNAs may serve as potential indicators of disease presence but more importantly, may have a role in disease characterization or as potential therapeutic targets. This review gives a brief overview of miRNA biochemistry and explores the evidence to date implicating these small molecules in the pathogenesis of bone tumors.
Nonsingular Black Holes in $f(R)$ Theories

We study the structure of a family of static, spherically symmetric space-times generated by an anisotropic fluid and governed by a particular type of f(R) theory. We find that for a range of parameters with physical interest, such solutions represent black holes with the central singularity replaced by a finite size wormhole. We show that time-like geodesics and null geodesics with nonzero angular momentum never reach the wormhole throat due to an infinite potential barrier. For null radial geodesics, it takes an infinite affine time to reach the wormhole. This means that the resulting space-time is geodesically complete and, therefore, nonsingular despite the generic existence of curvature divergences at the wormhole throat.
A quantitative analysis of factors contributing electronic data interchange adoption among Bruneian SMEs: A pilot study

Purpose – The primary purpose of this research is to examine and explore quantitatively the determining factors that contribute electronic data interchange (EDI) adoption among Brunei's small and medium enterprises (SMEs) not addressed previously.Design/methodology/approach – The study is based upon survey approach to collect the primary data from 50 SMEs in Brunei Darussalam based upon stratified random sampling plan. A one stage normative model that is associative in nature was developed based upon reviewing the previous researches and further in line with the research objectives. The model elicits six factors that are grouped in three categories, namely, organizational, environmental and technological.Findings – The findings based upon regression analysis indicate that factors such as perceived benefits, government support and management support are significant determinants of EDI adoption. The 35 percent of the total variance is explained by these three factors.Research limitations/implications – The .