Miracle-dz/UniFAR-FTUs huggingface dataset:
Social/emotional problems among children and youth with differing degrees of sensorineural hearing loss

The purpose of this investigation was to determine the extent to which differing degrees of hearing loss effect children's social/emotional development and whether the consequences are significant enough to warrant psychological, social and educational interventions. An attempt was made to answer the following questions: What is the prevalence of social/emotional problems among children with hearing impairments? Specifically, do children with moderate to severe hearing loss have more social/emotional difficulties than deaf children? This study is unique because very few studies involve the full range of hearing loss. Even though authors such as Berg, Blair, Viehweg and Wilson-Vlotman (1986) report that children who are hard-of-hearing can have just as many social/emotional adjustment difficulties as deaf children, usually only deaf children are included in research studies. This is unfortunate since the population of hard-of-hearing children is a considerably larger constituency. The participants in this study included 28 seven to fifteen years old students with sensorineural (permanent), bilateral hearing loss ranging from moderate to profound. The method involved the administration of the MeadowKendall Social Emotional Assessment Inventory (S.E.A.I.) for Hearing-Impaired Students and was administered by school personnel. Percentile scores on this instrument are
Modelling Agricultural Production Risk and the Adaptation to Climate Change

A model that integrates biophysical simulations in an economic model is used to analyze the impact of climate change on crop production. The biophysical model simulates future plant-management-climate relationships and the economic model simulates farmers’ adaptation actions to climate change using a nonlinear programming approach. Beyond the development of average yields, special attention is devoted to the impact of climate change on crop yield variability. This study analyzes corn and winter wheat production on the Swiss Plateau with respect to climate change scenarios that cover the period of 2030-2050. In our model, adaptation options such as changes in seeding dates, changes in production intensity and the adoption of irrigation farming are considered. Different scenarios of climate change, output prices and farmers’ risk aversion are applied in order to show the sensitivity of adaptation strategies and crop yields, respectively, on these factors. Our results show that adaptation actions, yields and yield variation highly depend on both climate change and output prices. The sensitivity of adaptation options and yields, respectively, to prices and risk aversion for winter wheat is much lower than for corn because of different growing periods. In general, our results show that both corn and winter wheat yields increase in the next decades. In contrast to other studies, we find the coefficient of variation of corn and winter wheat yields to decrease. We therefore conclude that simple adaptation measures are sufficient to take advantage of climate change in Swiss crop farming.
Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation

TGF-β1 has been long considered as a key mediator in renal fibrosis and induces renal scarring largely by activating its downstream Smad signaling pathway. Interestingly, while mice overexpressing active TGF-β1 develop progressive renal injury, latent TGF-β1 plays a protective role in renal fibrosis and inflammation. Under disease conditions, Smad2 and Smad3 are highly activated, while Smad7 is degraded through the ubiquitin proteasome degradation mechanism. In addition to TGF-β1, many pathogenic mediators such as angiotensin II and advanced glycation end products can also activate the Smad pathway via both TGF-β-dependent and independent mechanisms. Smads interact with other signaling pathways, such as the MAPK and NF-κB pathways, to positively or negatively regulate renal inflammation and fibrosis. Studies from gene knockout mice demonstrate that TGF-β1 acts by stimulating its downstream Smads to diversely regulate kidney injury. In the context of renal fibrosis and inflammation, Smad3 is pathogenic, while Smad2 and Smad7 are protective. Smad4 exerts its diverse roles by transcriptionally enhancing Smad3-mediated renal fibrosis while inhibiting NF-κB-driven renal inflammation via a Smad7-dependent mechanism. Furthermore, we also demonstrated that TGF-β1 acts by stimulating Smad3 to positively or negatively regulate microRNAs to exert its fibrotic role in kidney disease. In conclusion, TGF-β/Smad signaling is a major pathway leading to kidney disease. Smad3 is a key mediator in renal fibrosis and inflammation, whereas Smad2 and Smad7 are renoprotective. Smad4 exerts its diverse role in promoting renal fibrosis while inhibiting inflammation. Thus, targeting the downstream TGF-β/Smad3 signaling pathway by gene transfer of either Smad7 or Smad3-dependent microRNAs may represent a specific and effective therapeutic strategy for kidney disease.
A 20cm VLA Survey of Abell Clusters of Galaxies VI. Radio/Optical Luminosity Functions

From a statistically complete sample of 188 radio galaxies in Abell clusters, we examine the radio/optical correlations, the FR I/II division, and the univariate and bivariate luminosity functions. As suggested by Owen (1993), the FR I/II division is shown to be a strong function of the optical luminosity of the host galaxy (proportional to L_opt^2). This dependence is also seen in the bivariate luminosity function, which suggests that the evolutionary tracks of radio sources and/or the initial conditions in the source are governed by the host galaxy properties. The probability for detecting radio emission increases with optical luminosity. The optical dependence is clearly separated in the integral luminosity functions which can be used as a constraint to models of FR I radio power evolution. Additionally, the source counts from the integrated univariate radio luminosity function (RLF) are consistent with our suggestion in paper V that radio sources may be a transient phenomenon which occurs in all elliptical galaxies at some time (or several times) over their lifetime. We find no statistically significant differences in the luminosity functions between rich cluster samples and radio sources not selected to reside in clusters. These results suggest that all radio galaxies live in similar environments in that the optical luminosity and the properties of the host galaxy are the most important parameters which affect radio source formation and evolution.
Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms and Susceptibility for Cervical Lesions: A Meta-Analysis

Background The association between the methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and the susceptibility to cervical lesions was unclear. This study was designed to investigate their precise association using a large-scale meta-analysis. Methods The previous 16 studies were identified by searching PubMed, Embase and CBM databases. The crude odds ratios and their corresponding 95% confidence intervals (CIs) were used to estimate the association between the MTHFR C677T/A1298C polymorphisms and the susceptibility to the cervical lesions. The subgroup analyses were made on the following: pathological history, geographic region, ethnicity, source of controls and source of DNA for genotyping. Results Neither of the polymorphisms had a significant association with the susceptibility to the cervical lesions in all genetic models. Similar results were found in the subgroup analyses. No association was found between the MTHFR C677T polymorphism and the cervical lesions in the Asia or the America populations though a significant inverse association was found in the Europe population (additive model: P = 0.006, OR = 0.83, 95% CI = 0.72–0.95; CT vs. CC: P = 0.05, OR = 0.83, 95% CI = 0.69–1.00; TT vs. CC: P = 0.05, OR = 0.73, 95% CI = 0.53–1.00). Interestingly, women with the MTHFR A1298C polymorphisms had a marginally increased susceptibility to invasive cancer (ICC) when compared with no carriers but no statistically significant difference in the dominant model (P = 0.06, OR = 1.21, 95% CI = 0.99–1.49) and AC vs. AA (P = 0.09, OR = 1.21, 95% CI = 0.97–1.51). Conclusions The MTHFR C677T and A1298C polymorphisms may not increase the susceptibility to cervical lesions. However, the meta-analysis reveals a negative association between the MTHFR C677T polymorphisms and the cervical lesions, especially in the European populations. The marginal association between the MTHFR A1298C polymorphisms and the susceptibility to cervical cancer requires a further study.
Inhibition of Protein Kinase C/Twist1 Signaling Augments Anticancer Effects of Androgen Deprivation and Enzalutamide in Prostate Cancer

Purpose: The progression of prostate cancer to metastatic and castration-resistant disease represents a critical step. We previously showed that the transcription factor Twist1, which promotes epithelial–mesenchymal transition, was involved in castration-resistant progression. Similarly, protein kinase C (PKC) has been implicated in both metastatic progression and castration resistance in prostate cancer. Experimental Design: In this study, we aimed to elucidate the role of PKC/Twist1 signaling in castration resistance, and to apply this information to the development of a novel therapeutic concept using PKC inhibitor Ro31-8220 against prostate cancer using various prostate cancer cell lines. Results: Androgen deprivation and the next-generation antiandrogen enzalutamide induced PKC activation and Twist1 expression, which were reversed by the PKC inhibitor Ro31-8220. Ro31-8220 suppressed cell proliferation in androgen-dependent prostate cancer LNCaP cells, which was augmented by its combination with androgen deprivation or enzalutamide. The favorable anticancer effects of the combination of Ro31-8220 and enzalutamide were also observed in castration-resistant C4-2 and 22Rv1 cells. Furthermore, PKC phosphorylation was elevated in castration-resistant and enzalutamide-resistant cells compared with their parental cells, leading to persistent sensitivity to Ro-31-8220 in castration- and enzalutamide-resistant cells. Conclusions: Taken together, these findings indicate that PKC/Twist1 signaling contributes to castration resistance as well as enzalutamide resistance in prostate cancer, and suggest that therapeutics targeting PKC/Twist1 signaling, such as PKC inhibitors, represent a promising novel therapeutic strategy for prostate cancer, especially castration-resistant prostate cancer, when combined with enzalutamide. Clin Cancer Res; 20(4); 951–61. ©2013 AACR.
Premature dismissal of high‐redshift elliptical galaxies

It has recently been argued that single-collapse high-redshift models for elliptical galaxy formation can be rejected because they predict large numbers of very red galaxies at intermediate redshifts, which are not seen in deep optical--infrared surveys. We argue, however, that this conclusion is premature since, while much effort has been invested in refining the predictions of hierarchical CDM models, only very simplistic models have been used to study the evolution of galaxies in other cosmogonies (e.g. isocurvature models). We demonstrate that the use of a more realistic multizone chemo-dynamical single-collapse model yields colours at intermediate redshifts that are much bluer than those inferred from the one-zone model, and indeed are comparable to those predicted by hierarchical merging, despite still allowing > 90 per cent of the final stellar mass of elliptical galaxies to be formed in the first Gyr of their evolution. We, therefore, conclude that the one-zone model should be avoided for prediction of the colours of high-redshift galaxies and that the use of realistic multizone models allows the existence of ellipticals at high redshift, their dismissal being premature.
Predictions based on Twitter — A critical view on the research process

Twitter data is increasingly used to make predictions about real-world events. However recently, several studies directly or indirectly questioned proposed Twitter prediction procedures. In this paper, we conduct a literature review to investigate the research processes adopted by previous Twitter prediction studies in detail. We first identify the actors involved, and then we study how they influence the different phases of the research process. We found that in Twitter prediction research up to four actors perform several sampling, filtering, classification and assessment decisions throughout the development of prediction models. If these decisions and the reasons behind them are not sufficiently documented, the developed prediction methods cannot be reproduced in future research and consequently their validity and reliability are hard to assess.
Effects of Converting Bilateral Cochlear Implant Subjects to a Strategy with Increased Rate and Number of Channels

Objectives: Three different Advanced Bionics processing strategies were evaluated: 1) 8-channel, 813 pulses per second (pps), Continuous Interleaved Sampling (CIS); 2) 16-channel, 5,100 pps, HiResolution Paired (HiRes P); and 3) 16-channel, 2,900 pps, HiResolution Sequential (HiRes S). Methods: Seven adult bilateral Clarion CII cochlear implant recipients who had been using a CIS processing strategy for at least 18 months participated in this study. Sentence recognition in multitalker babble from the front was collected on subjects using their CIS strategy and after subjects were programmed for the first time with HiRes P and HiRes S strategies. An ABAB design was implemented for 1 month whereby subjects used each HiResolution strategy every other day. Sentence recognition testing was repeated at the 1- and 3-month post-HiResolution test intervals. Results: Comparisons between the CIS and HiResolution strategies showed immediate improvements for 5 subjects in favor of the HiResolution strategies. After 1 month of alternating between the HiRes P and HiRes S strategies, remarkably, 2 subjects showed improvements of 60%, 2 subjects showed improvements of 40%, and 2 subjects showed improvements of 30% over the CIS strategy that they had previously used for at least 18 months. The results after 3 months of use were consistent with those obtained at 1 month. Conclusions: The HiRes S and HiRes P strategies resulted in dramatic improvements in speech perception in noise for a subset of subjects who had been using the CIS strategy bilaterally. This finding demonstrates that these subjects were able to tolerate a more difficult signal-to-noise ratio. Further work is needed to determine the independent effects of rate versus number of channels.
Analysis of Netizen's Affective Tendency on Public Opinion

One can express personal experiences and opinions on hot events. For a public opinion, netizen may support or oppose it. The research of the affective tendency of netizen on public opinion is of great value. In this paper, we analyze the features of public opinion sentence and making use of natural language processing techniques to introduce a new approach that can compute the affective tendency of netizen on public opinion and the distribution of different tendency. The experimental result shows that the approach is qualitatively quite useful when used to analyze the affective tendency of netizen on public opinion from some websites.
Poor prognosis of arthritis-associated pyoderma gangrenosum.

BACKGROUND The association between pyoderma gangrenosum (PG) and arthritis is well established. We have observed a refractory population of patients with arthritis-associated PG (PGA). We, therefore, tested the hypothesis that differences exist in response to treatment in patients with PGA compared with patients with PG without arthritis. OBSERVATIONS We performed a review of patients with PG during a 2-year period. Patients had noninfectious chronic ulcerations clinically typical for PG, exclusion of relevant differential diagnoses, and consistent histopathological features. Outcomes compared between patients with arthritis (PGA) and without arthritis (PG) included complete healing, percentage change in wound size, and duration of therapy. Of 10 PG ulcers, 7 healed, compared with 2 of 8 PGA ulcers. There was a greater mean percentage decrease in wound size in the PG vs the PGA ulcers (78.9% vs 23.4%; P =.10) and a shorter mean duration of treatment (8.7 vs 14.8 months; P =.18). CONCLUSIONS The ulcers of patients with PGA seem more refractory to treatment than the ulcers of patients with PG alone. Those with PGA ulcers represent a refractory subset of patients, and the ulcers are possibly secondary to unique pathophysiological features.
Dynamic potential-based reward shaping

Potential-based reward shaping can significantly improve the time needed to learn an optimal policy and, in multi-agent systems, the performance of the final joint-policy. It has been proven to not alter the optimal policy of an agent learning alone or the Nash equilibria of multiple agents learning together. However, a limitation of existing proofs is the assumption that the potential of a state does not change dynamically during the learning. This assumption often is broken, especially if the reward-shaping function is generated automatically. In this paper we prove and demonstrate a method of extending potential-based reward shaping to allow dynamic shaping and maintain the guarantees of policy invariance in the single-agent case and consistent Nash equilibria in the multi-agent case.
Tissue Specific Expression of Cre in Rat Tyrosine Hydroxylase and Dopamine Active Transporter-Positive Neurons

The rat is a preferred model system over the mouse for neurological studies, and cell type-specific Cre expression in the rat enables precise ablation of gene function in neurons of interest, which is especially valuable for neurodegenerative disease modeling and optogenetics. Yet, few such Cre rats are available. Here we report the characterization of two Cre rats, tyrosine hydroxylase (TH)-Cre and dopamine active transporter (DAT or Slc6a3)-Cre, by using a combination of immunohistochemistry (IHC) and mRNA fluorescence in situ hybridization (FISH) as well as a fluorescent reporter for Cre activity. We detected Cre expression in expected neurons in both Cre lines. Interestingly, we also found that in Th-Cre rats, but not DAT-Cre rats, Cre is expressed in female germ cells, allowing germline excision of the floxed allele and hence the generation of whole-body knockout rats. In summary, our data demonstrate that targeted integration of Cre cassette lead to faithful recapitulation of expression pattern of the endogenous promoter, and mRNA FISH, in addition to IHC, is an effective method for the analysis of the spatiotemporal gene expression patterns in the rat brain, alleviating the dependence on high quality antibodies that are often not available against rat proteins. The Th-Cre and the DAT-Cre rat lines express Cre in selective subsets of dopaminergic neurons and should be particularly useful for researches on Parkinson’s disease.
Public Transportation: An Investigation of Barriers for People With Disabilities

The physical accessibility of public transportation increased nationwide following the passage of the Americans With Disabilities Act (ADA) in 1990. Despite removal of many physical barriers within fixed-route systems, significant barriers to overall access of public transportation systems are still widespread. The purpose of the current study was to provide a full description of barriers experienced by individuals with disabilities when using the public transportation and the complementary paratransit services. An online survey was developed and disseminated to contacts of the National Network of ADA Centers, and 4,161 individuals responded. Results highlight significant barriers for people with disabilities who use public transportation and complementary paratransit services. Barriers to these transit systems are physical and attitudinal in nature, and as a result, modifications to the physical environment and educational opportunities to reduce negative attitudes toward individuals with disabilities are recommended.
Can psychological interventions increase optimism? A meta-analysis

Abstract Greater optimism is related to better mental and physical health. A number of studies have investigated interventions intended to increase optimism. The aim of this meta-analysis was to consolidate effect sizes found in randomized controlled intervention studies of optimism training and to identify factors that may influence the effect of interventions. Twenty-nine studies, with a total of 3319 participants, met criteria for inclusion in the analysis. A significant meta-analytic effect size, g = . 41, indicated that, across studies, interventions increased optimism. Moderator analyses showed that studies had significantly higher effect sizes if they used the Best Possible Self intervention, provided the intervention in person, used an active control, used separate positive and negative expectancy measures rather than a version of the LOT-R, had a final assessment within one day of the end of the intervention, and used completer analyses rather than intention-to-treat analyses. The results indicate that psychological interventions can increase optimism and that various factors may influence effect size.