Miracle-dz/UniFAR-FTUs huggingface dataset:
Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia.

CONTEXT Negative symptoms of schizophrenia are a prominent feature of the illness, and frequently remain refractory to treatment. Dehydroepiandrosterone (DHEA), along with its sulfated form, DHEA-S, is an important circulating neurosteroid with several vital neurophysiological functions, including the regulation of neuronal excitability and function. OBJECTIVE Since the administration of DHEA has demonstrated improvement in mood, sense of well-being, interest, activity, and energy in several subpopulations, we investigate the efficacy of DHEA in the management of the negative symptoms of schizophrenia. DESIGN Thirty DSM-IV-diagnosed schizophrenic patients with prominent negative symptoms (inpatients in a large referral state hospital) were randomized to receive either DHEA or placebo in double-blind fashion, in addition to regular antipsychotic medication, dose-stabilized prior to study entry. The DHEA was titrated up to a dose of 100 mg in divided doses during 6 weeks. RESULTS Results indicated significant improvement in negative symptoms (P<.001), as well as in depressive (P<.05) and anxiety (P<.001) symptoms in individuals receiving DHEA. This effect was especially noted in women. The improvement in negative symptoms was independent of improvement in depression. No differences were noted on the positive symptom subscale of the Positive and Negative Syndrome Scale (PANSS) or on the total PANSS score as compared with placebo. Subjects receiving DHEA demonstrated a significant increase in DHEA (P<.05) and DHEA-S (P<.01) plasma levels, without changes in cortisol levels. Increases in DHEA and plasma DHEA-S levels were correlated with improvement in negative symptoms (P<.05), but not with improvement in depressive and anxiety symptoms. No obvious adverse effects were experienced by participating subjects. CONCLUSIONS Our preliminary observations report for the first time in double-blind fashion the efficacy of DHEA augmentation in the management of negative, depressive, and anxiety symptoms of schizophrenia. The findings from this study raise important issues regarding the role of neurosteroids in general, and DHEA in particular, in the ongoing symptomatology and pharmacotherapy of schizophrenia.
The boundaries of languages and disciplines : How ideologies construct difference

Les AA. affirment que l'on tend a identifier une langue et un espace geographique specifique, une nation, une culture. Ils estiment que cette perspective derive de l'analyse des processus de differenciation politique qui ont marque l'histoire de l'Europe. Ils considerent dans le meme temps qu'elle est inadequate. Ils montrent que les frontieres entre langues et dialectes sont des constructions sociales. Ils etudient les processus grâce auxquels une unite linguitique devient une unite sociale definie. Ils comparent ce type de phenomene aux differenciations qui s'operent au sein des disciplines scientifiques. Ils mettent en relief les processus ideologiques qui les sous-tendent
The Blues Broaden, but the Nasty Narrows

Positive and negative affects high in motivational intensity cause a narrowing of attentional focus. In contrast, positive affects low in motivational intensity cause a broadening of attentional focus. The attentional consequences of negative affects low in motivational intensity have not been experimentally investigated. Experiment 1 compared the attentional consequences of negative affect low in motivational intensity (sadness) relative to a neutral affective state. Results indicated that low-motivation negative affect caused attentional broadening. Experiment 2 found that disgust, a high-motivation negative affect not previously investigated in attentional studies, narrowed attentional focus. These experiments support the conceptual model linking high-motivation affective states to narrowed attention and low-motivation affective states to broadened attention.
Secure index coding: Existence and construction

We investigate the construction of weakly-secure index codes for a sender to send messages to multiple receivers with side information in the presence of an eavesdropper. We derive a sufficient and necessary condition for the existence of index codes that are secure against an eavesdropper with access to any subset of messages of cardinality t, for any fixed t. In contrast to the benefits of using random keys in secure network coding, we prove that random keys do not promote security in three classes of index-coding instances.
Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure.

CONTEXT Peripheral and central endocannabinoids and cognate acylethanolamides (AEs) may play important but distinct roles in regulating energy balance. OBJECTIVE We hypothesized that in humans central/peripheral endocannabinoids are differently associated with adiposity and energy expenditure and differ by race. DESIGN We examined associations of arachindonoylethanolamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleoylethanolamide (OEA) assayed in plasma and cerebrospinal fluid (CSF) with race, adiposity, and energy expenditure. SETTING/PARTICIPANTS In this monitored clinical inpatient study, CSF was obtained by lumbar puncture in 27 individuals (12 Caucasian, 11 American Indian, and four African-American). Twenty-four hour and sleep energy expenditure were measured by indirect calorimetry in a respiratory chamber. MAIN OUTCOME MEASURE Samples were analyzed from a previous study originally designed to test a blood-brain barrier leptin transport deficit in human obesity. RESULTS CSF (but not peripheral) 2-arachidonoylglycerol was significantly increased in American Indians compared with Caucasians (18.48 ± 6.17 vs. 10.62 ± 4.58 pmol/ml, P < 0.01). In the whole group, peripheral AEs were positively but in CSF negatively associated with adiposity. However, in multivariate models adjusted for the other peripheral and CSF AEs, peripheral arachindonoylethanolamide was the only AE significantly associated with adiposity. Interestingly, CSF OEA concentrations were positively associated with adjusted 24 hour and sleep energy expenditure (r = 0.47, P < 0.05; r = 0.42, P < 0.05), but peripheral OEA was not. CONCLUSIONS These data indicate a central alteration of the endocannabinoid system in American Indians and furthermore show that AEs in both compartments play an important but distinct role in human energy balance regulation.
The Impact of Men's and Women's Retirement on Marital Relations: A Comparative Analysis

ABSTRACT The study examined whether men's and women's retirement have a differential impact on several aspects of marital life: Power relations (as reflected in decision-making), spousal resources, division of household tasks, and quality of marriage. Questionnaires were distributed to a sample of 519 pre-retired and retired Israelis. The findings indicate that in general, both men's and women's retirement have a similar impact on marital relations in all of the areas examined. No appreciable change in spousal resources was found after retirement, but there was evidence of change in decision-making patterns about spending time and carrying out feminine and general tasks. Retired respondents of both sexes reported fewer marital complaints than the pre-retired respondents, but also expressed less marital enjoyment. It was also found that men's retirement has a different impact than women's retirement on decisions about household affairs and performance of feminine tasks. In addition, gender-based differences were found in several areas, irrespective of employment status. The women reported higher quality of marriage than did the men, and more resources for strengthening the family, whereas the men perceived themselves as making more decisions in the important areas of life, as more hardy, and as controlling the family's financial resources.
Diarrhea in Developed and Developing Countries: Magnitude, Special Settings, and Etiologies

Abstract Diarrheal diseases are major causes of morbidity, with attack rates ranging from two to 12 or more illnesses per person per year in developed and developing countries. In addition, diarrheal illnesses account for an estimated 12,600 deaths each day in children in Asia, Africa, and Latin America. The causes of diarrhea include a wide array of viruses, bacteria, and parasites, many of which have been recognized only in the last decade or two. While enterotoxigenic Escherichia coli and rotaviruses predominate in developing areas, Norwalk-like viruses, Campylobacter jejuni, and cytotoxigenic Clostridium difficile are seen with increasing frequency in developed areas; and Shigella, Salmonella, Cryptosporidium species, and Giardia lamblia are found throughout the world. The rational management of infectious diarrhea requires the highly selective use of laboratory tests for these varied etiologic agents, depending on the clinical and epidemiologic setting. The purpose of this review is to provide an overview of the magnitude, special settings, and etiologies of diarrhea endemic to developed and developing countries. This information permits a practical approach to the diagnosis and management of common diarrheal illnesses in different settings.
Therapy-Related Myeloid Malignancies in

Therapy related myeloid malignancies are an increasingly recognized treat complication in patients undergoing therapy for multiple myeloma. The main predisposing factors are the alkylating agents, topoisomerase II inhibitors and radiotherapy, but recently questions have been raised regarding the immunomodulatory agent lenal antimyeloma agents in the context of therapy related myeloid malignancies. The duration of treatment and the time from diagnosis are the main contributing factors in alkylating induced myeloid malignancies which occur being the characteristic finding. High dose therapy (HDT) does not seem to be a major contributing factor per se in multiple myeloma. In a number of large published series, all the factors relat therapy-induced myelodysplasia were defined prior to HDT. Topoisomerase II inhibitors induce mainly acute leukemias which invariably correlate with dysregulation of the MLL gene. Radiotherapy causes therapy related myelodysplasia if applied in bone especially if combined with chemotherapy. Therapy related myeloid malignancies generally herald a poor prognosis. Karyotypic abnormalities seem to be the main prognostic factor. In all cases the risk for therapy related myeloid mal
Modeling and Analysis of Noise Sources for Thin-Film Magnetoelectric Sensors Based on the Delta-E Effect

We present a comprehensive noise model for an electromechanical resonator that is utilized as a magnetic field sensor. The cantilever-type sensor is coated with a magnetostrictive film that exhibits a change in elastic modulus E with a magnetic field and therefore detunes the resonator—the so-called delta-E effect. The noise model contains all relevant noise sources from the operational electronics, the wiring, and the sensor itself. Measurements show good agreement up to a certain excitation voltage, where an additional dominant noise source appears. It is identified as originating from the magnetic film. With the results of the model, the operational parameters of such sensors are discussed. The model predicts that the limit of detection at 10 Hz for the present sensors can be improved to 60 pT/(Hz) $^{1/2}$ if the magnetic noise is eliminated.
Relationship between macular pigment and visual function in subjects with early age-related macular degeneration

Purpose To investigate the relationship between macular pigment (MP) and visual function in subjects with early age-related macular degeneration (AMD). Methods 121 subjects with early AMD enrolled as part of the Central Retinal Enrichment Supplementation Trial (CREST; ISRCTN13894787) were assessed using a range of psychophysical measures of visual function, including best corrected visual acuity (BCVA), letter contrast sensitivity (CS), mesopic and photopic CS, mesopic and photopic glare disability (GD), photostress recovery time (PRT), reading performance and subjective visual function, using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). MP was measured using customised heterochromatic flicker photometry. Results Letter CS, mesopic and photopic CS, photopic GD and mean reading speed were each significantly (p<0.05) associated with MP across a range of retinal eccentricities, and these statistically significant relationships persisted after controlling for age, sex and cataract grade. BCVA, NEI VFQ-25 score, PRT and mesopic GD were unrelated to MP after controlling for age, sex and cataract grade (p>0.05, for all). Conclusions MP relates positively to many measures of visual function in unsupplemented subjects with early AMD. The CREST trial will investigate whether enrichment of MP influences visual function among those afflicted with this condition. Trial registration number ISRCTN13894787.
Predictors of pneumonia in lower respiratory tract infections: 3C prospective cough complication cohort study

The aim was to aid diagnosis of pneumonia in those presenting with lower respiratory tract symptoms in routine primary care. A cohort of 28 883 adult patients with acute cough attributed to lower respiratory tract infections (LRTIs) was recruited from 5222 UK practices in 2009–13. Symptoms, signs and treatment were recorded at presentation and subsequent events followed-up for 30 days by chart review. The predictive value of patient characteristics, presenting symptoms and clinical findings for the diagnosis of pneumonia in the first 7 days was established. Of the 720 out of 28 883 (2.5.%) radiographed within 1 week of the index consultation, 115 (16.0%; 0.40% of 28 883) were assigned a definite or probable pneumonia diagnosis. The significant independent predictors of radiograph-confirmed pneumonia were temperature >37.8°C (RR 2.6; 95% CI 1.5–4.8), crackles on auscultation (RR 1.8; 1.1–3.0), oxygen saturation <95% (RR 1.7; 1.0–3.1) and pulse >100·min–1 (RR 1.9; 1.1–3.2). Most patients with pneumonia (99/115, 86.1%) exhibited at least one of these four clinical signs; the positive predictive value of having at least one of these signs was 20.2% (95% CI 17.3–23.1). In routine practice, radiograph-confirmed pneumonia as a short-term complication of LRTI is very uncommon (one in 270). Pulse oximetry may aid the diagnosis of pneumonia in this setting. Pulse oximetry probably has a role in the diagnosis of pneumonia in the community http://ow.ly/QpWc30fVM2j
THE ETIOLOGY OF ACUTE UPPER RESPIRATORY INFECTION (COMMON COLD)

Experimental upper respiratory infections similar to "common colds" were transmitted singly and in series through two and four passages in nine out of fifteen persons, by intransal inoculations with bacteria-free filtrates of nasopharyngeal washings obtained from individuals ill with natural "colds. " These observations conform with those reported by previous workers and lend further support to the view that the incitant of the "common cold" is a filtrable virus.
Psychological morbidity and quality of life in women with advanced breast cancer: A cross-sectional survey

Objective: Our purpose was to determine the frequency of psychiatric morbidity and to assess the quality of life of women with advanced breast cancer. Methods: The 227 women in the sample were recruited in Melbourne, Australia, and were interviewed (prior to intervention) for a randomized controlled trial of supportive-expressive group therapy. The main outcome measures were DSM–IV psychiatric diagnoses plus quality of life data based on the EORTC QLQ-C30 (core) and QLQ-BR23 (breast module) instruments. Results: Forty-two percent of the women (97/227) had a psychiatric disorder; 35.7% (81) of these had depression or anxiety or both. Specific diagnoses were minor depression in 58 women (25.6%), major depression in 16 (7%), anxiety disorder in 14 (6.2%), and phobic disorder in 9 (4%). Seventeen (7.5%) women had more than one disorder. In terms of quality of life, one-third felt less attractive, one-quarter were dissatisfied with their body image, and, in most, sexual interest had waned. Menopausal symptoms such as hot flashes affected less than one-third, whereas symptoms of lymphedema were experienced by 26 (11.5%). Significance: Women with advanced breast cancer have high rates of psychiatric and psychological disturbance. Quality of life is substantially affected. Clinicians need to be vigilant in monitoring psychological adjustment as part of a comprehensive biopsychosocial approach.
Factors Affecting Users' Intention to Continue Using Virtual Community

A research model of individual users' continuance intention to use virtual communities is proposed and empirically examined in this study. To test this model, an online survey was conducted among users of a Web-based Bulletin Board System sponsored by a local university in mainland China. Consistent with prior information systems continuance studies, the results showed that satisfaction was the most salient determinant of continuance intention to participate in the virtual community while sense of belonging had a significant but weaker influence on it. Contrary to the proposed hypotheses, only positive disconfirmations of purposive value and entertainment value significantly affected user satisfaction. Implications for both researchers and practitioners are discussed.
A Roadmap for Reconfiguring Industrial Enterprises as a Consequence of Global Economic Crisis (GEC)

Due to the existing depression, industrial enterprises in most of the world require to be reconfigured and/or reorganized especially the manufacturing firms (companies). As a consequence of the global economic crisis (GEC), great political and economical maybe changed and some companies will go out from business and others will be merged with other firms. Also, a big effecting will be represented in unemployment. The industrial enterprises will start to deal intensively for better utilization of resources (e.g., equipments, machines, etc.) and human resources. There are a lot of issues needed to be addressed to cope with this recession. The most important issue is then the opportunity to learn new skills and techniques. The other issues which this paper illustrated representing in complexity level of industrial enterprises, designing hybrid or innovative manufacturing systems, applied manufacturing strategies and philosophies, product development, management for change, and good accounting system. In this paper, a conceptual framework as a roadmap for discussing these issues of reconfiguring industrial enterprises will be explained and discussed. The analysis shows that reconfiguring industrial enterprises is not easy task and a multi-dimensional problem.
Modeling the space of camera response functions

Many vision applications require precise measurement of scene radiance. The function relating scene radiance to image intensity of an imaging system is called the camera response. We analyze the properties that all camera responses share. This allows us to find the constraints that any response function must satisfy. These constraints determine the theoretical space of all possible camera responses. We have collected a diverse database of real-world camera response functions (DoRF). Using this database, we show that real-world responses occupy a small part of the theoretical space of all possible responses. We combine the constraints from our theoretical space with the data from DoRF to create a low-parameter empirical model of response (EMoR). This response model allows us to accurately interpolate the complete response function of a camera from a small number of measurements obtained using a standard chart. We also show that the model can be used to accurately estimate the camera response from images of an arbitrary scene taken using different exposures. The DoRF database and the EMoR model can be downloaded at http://www.cs. columbia.edu/CAVE.
Zinc as a Neuromodulator in the Central Nervous System with a Focus on the Olfactory Bulb

The olfactory bulb (OB) is central to the sense of smell, as it is the site of the first synaptic relay involved in the processing of odor information. Odor sensations are first transduced by olfactory sensory neurons (OSNs) before being transmitted, by way of the OB, to higher olfactory centers that mediate olfactory discrimination and perception. Zinc is a common trace element, and it is highly concentrated in the synaptic vesicles of subsets of glutamatergic neurons in some brain regions including the hippocampus and OB. In addition, zinc is contained in the synaptic vesicles of some glycinergic and GABAergic neurons. Thus, zinc released from synaptic vesicles is available to modulate synaptic transmission mediated by excitatory (e.g., N-methyl-D aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)) and inhibitory (e.g., gamma-aminobutyric acid (GABA), glycine) amino acid receptors. Furthermore, extracellular zinc can alter the excitability of neurons through effects on a variety of voltage-gated ion channels. Consistent with the notion that zinc acts as a regulator of neuronal activity, we and others have shown zinc modulation (inhibition and/or potentiation) of amino acid receptors and voltage-gated ion channels expressed by OB neurons. This review summarizes the locations and release of vesicular zinc in the central nervous system (CNS), including in the OB. It also summarizes the effects of zinc on various amino acid receptors and ion channels involved in regulating synaptic transmission and neuronal excitability, with a special emphasis on the actions of zinc as a neuromodulator in the OB. An understanding of how neuroactive substances such as zinc modulate receptors and ion channels expressed by OB neurons will increase our understanding of the roles that synaptic circuits in the OB play in odor information processing and transmission.
Comparison of Recent Machine Learning Techniques for Gender Recognition from Facial Images

Recently, several machine learning methods for gender classi- fication from frontal facial images have been proposed. Their variety suggests that there is not a unique or generic solution to this problem. In addition to the diversity of methods, there is also a diversity of benchmarks used to assess them. This gave us the motivation for our work: to select and compare in a concise but reliable way the main state-of-the-art methods used in automatic gender recognition. As expected, there is no overall winner. The winner, based on the accuracy of the classification, depends on the type of benchmarks used.