Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance enhancement on sub-70 nm strained silicon SOI MOSFETs on ultra-thin thermally mixed strained silicon/SiGe on insulator (TM-SGOI) substrate with raised S/D

High quality ultra-thin TM-SGOI substrate with T/sub SOI/ < 55 nm is developed to combine the device benefits of strained silicon and SOI. 80-90% Id,sat and electron mobility increase are shown in long channel nFET device. For the first time, 20-25% device performance enhancement is demonstrated at 55 nm short channel strained silicon SGOI nFET devices.
An experiment on the effect of design recording on impact analysis

An experimental study is presented in which participants perform impact analysis on alternate forms of design record information. The primary objective of the research is to assess the software maintainer's performance with respect to various approaches of design recording. One of the approaches is the model dependency descriptor, which includes decision capturing and explicit traceability links between software objects and decisions. Results indicate that design recording approaches slightly differ in work completeness and time-to-finish, but the model dependency descriptor leads to the most accurate impact analysis. These results suggest that design records have the potential to be effective for software maintenance, but training and process discipline is needed to make design recording worthwhile. <<ETX>>
Equivalent circuit model of on-wafer CMOS interconnects for RFICs

This paper investigates the properties of the on-wafer interconnects built in a 0.18-/spl mu/m CMOS technology for RF applications. A scalable equivalent circuit model is developed. The model parameters are extracted directly from the on-wafer measurements and formulated into empirical expressions. The expressions are in functions of the length and the width of the interconnects. The proposed model can be easily implemented into commercial RF circuit simulators. It provides a novel solution to include the frequency-variant characteristics into a circuit simulation. The silicon-verified accuracy is proved to be up to 25 GHz with an average error less than 2%. Additionally, equivalent circuit model for longer wires can be obtained by cascading smaller subsections together. The scalability of the propose model is demonstrated.
Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides

P-glycoprotein (ABCB1), a member of the ABC superfamily, functions as an ATP-driven multidrug efflux pump. The catalytic cycle of ABC proteins is believed to involve formation of a sandwich dimer in which two ATP molecules are bound at the interface of the nucleotide binding domains (NBDs). However, such dimers have only been observed in isolated NBD subunits and catalytically arrested mutants, and it is still not understood how ATP hydrolysis is coordinated between the two NBDs. We report for the first time the characterization of an asymmetric state of catalytically active native P-glycoprotein with two bound molecules of adenosine 5′-(γ-thio)triphosphate (ATPγS), one of low affinity (Kd 0.74 mm), and one “occluded” nucleotide of 120-fold higher affinity (Kd 6 μm). ATPγS also interacts with P-glycoprotein with high affinity as assessed by inhibition of ATP hydrolysis and protection from covalent labeling of a Walker A Cys residue, whereas other non-hydrolyzable ATP analogues do not. Binding of ATPγS (but not ATP) causes Trp residue heterogeneity, as indicated by collisional quenching, suggesting that it may induce conformational asymmetry. Asymmetric ATPγS-bound P-glycoprotein does not display reduced binding affinity for drugs, implying that transport is not driven by ATP binding and likely takes place at a later stage of the catalytic cycle. We propose that this asymmetric state with two bound nucleotides represents the next intermediate on the path toward ATP hydrolysis after nucleotide binding, and an alternating sites mode of action is achieved by simultaneous switching of the two active sites between high and low affinity states.
Overexpression of Cyclin‐dependent Kinase‐activating CDC25B Phosphatase in Human Gastric Carcinomas

CDC25 phosphatases activate cyclin‐dependent kinases by removing inhibitory phosphate groups on the molecules and positively regulate the cell cycle progression. The expression of CDC25A, B and C was examined in gastric carcinoma cell lines and gastric carcinoma tissues by northern blotting and immunohistochemistry. The gastric carcinoma cell lines expressed CDC25A, B and C mRNA at various levels. The expression levels of CDC25B were generally higher than those of CDC25A and C. Of the 40 gastric carcinomas, 70% of the tumors expressed CDC25B mRNA at higher levels than the corresponding normal mucosas, while 38% overexpressed CDC25A mRNA. The CDC25C expression was at very low or undetectable levels. No obvious correlation was detected between the expression of CDC25B and p53 gene mutations. Inununohistochemically, CDC25‐positive tumor cells were detected in 43 (78%) of 55 gastric carcinoma cases, of which 27 (49%) were strongly positive. Strong expression of CDC25B protein was associated with advanced stage and deep invasion. Furthermore, the incidence of strong expression was significantly higher in carcinomas with nodal metastasis than in those without metastasis. These findings suggest that Overexpression of CDC25B may favor development and progression and may be an indicator of malignant behavior of gastric carcinomas.
Atrial fibrillation, physical activity and endurance training.

INTRODUCTION Clinical practice and the results of some studies may indicate that physical exercise in the form of endurance training may influence the development of atrial fibrillation (AF). The aim of this paper is to evaluate the scientific background for the hypothesis that there is a connection between physical activity and AF. MATERIAL AND METHOD This paper is a review article based on searches in PubMed on specific topics, limited to the period 1995 through March 2011. We found 17 original articles and three relatively recent reviews. Each was read by at least two of the authors and then discussed. Seven of the original articles were excluded for methodological reasons, and we therefore discuss the other ten. RESULTS We found support for the hypothesis that systematic high intensity endurance training such as running can increase the risk of AF, whereas the studies provide no evidence that less intensive physical exercise such as walking increases the risk. Several of the studies have methodological weaknesses. INTERPRETATION Important questions remain unanswered. There is a need for more studies that can shed light on the connection between training intensity, total volume of intensive endurance training, age-related changes and AF. Studies that include women are also needed.
Action anticipation beyond the action observation network: a functional magnetic resonance imaging study in expert basketball players

The ability to predict the actions of others is quintessential for effective social interactions, particularly in competitive contexts (e.g. in sport) when knowledge about upcoming movements allows anticipating rather than reacting to opponents. Studies suggest that we predict what others are doing by using our own motor system as an internal forward model and that the fronto‐parietal action observation network (AON) is fundamental for this ability. However, multiple‐duty cells dealing with action perception and execution have been found in a variety of cortical regions. Here we used functional magnetic resonance imaging to explore, in expert basketball athletes and novices, whether the ability to make early predictions about the fate of sport‐specific actions (i.e. free throws) is underpinned by neural regions beyond the classical AON. We found that, although involved in action prediction, the fronto‐parietal AON was similarly activated in novices and experts. Importantly, athletes exhibited relatively greater activity in the extrastriate body area during the prediction task, probably due to their expert reading of the observed action kinematics. Moreover, experts exhibited higher activation in the bilateral inferior frontal gyrus and in the right anterior insular cortex when producing errors, suggesting that they might become aware of their own errors. Correct action prediction induced higher posterior insular cortex activity in experts and higher orbito‐frontal activity in novices, suggesting that body awareness is important for performance monitoring in experts, whereas novices rely more on higher‐order decision‐making strategies. This functional reorganization highlights the tight relationship between action anticipation, error awareness and motor expertise leading to body‐related processing and differences in decision‐making processes.
Stochastic Synchrony of Chaos in a Pulse-Coupled Neural Network with Both Chemical and Electrical Synapses Among Inhibitory Neurons

The synchronous firing of neurons in a pulse-coupled neural network composed of excitatory and inhibitory neurons is analyzed. The neurons are connected by both chemical synapses and electrical synapses among the inhibitory neurons. When electrical synapses are introduced, periodically synchronized firing as well as chaotically synchronized firing is widely observed. Moreover, we find stochastic synchrony where the ensemble-averaged dynamics shows synchronization in the network but each neuron has a low firing rate and the firing of the neurons seems to be stochastic. Stochastic synchrony of chaos corresponding to a chaotic attractor is also found.
On the Relations of Correlation Filter Based Trackers and Struck

In recent years, two types of trackers, namely correlation filter based tracker (CF tracker) and structured output tracker (Struck), have exhibited the state-of-the-art performance. However, there seems to be lack of analytic work on their relations in the computer vision community. In this paper, we investigate two state-of-the-art CF trackers, i.e., spatial regularization discriminative correlation filter (SRDCF) and correlation filter with limited boundaries (CFLB), and Struck, and reveal their relations. Specifically, after extending the CFLB to its multiple channel version we prove the relation between SRDCF and CFLB on the condition that the spatial regularization factor of SRDCF is replaced by the masking matrix of CFLB. We also prove the asymptotical approximate relation between SRDCF and Struck on the conditions that the spatial regularization factor of SRDCF is replaced by an indicator function of object bounding box, the weights of SRDCF in its loss item are replaced by those of Struck, the linear kernel is employed by Struck, and the search region tends to infinity. Extensive experiments on public benchmarks OTB50 and OTB100 are conducted to verify our theoretical results. Moreover, we explain how detailed differences among SRDCF, CFLB, and Struck would give rise to slightly different performances on visual sequences
Frequency Dependence of the Drifting Sub-Pulses of PSR B0031–07

The well known drifter PSR B0031-07 is known to exhibit drifting sub-pulses where the spacing between the drift bands (P3) shows three distinct modes A, B and C corresponding to 13, 7 and 4 times the pulsar period, respectively. We have investigated periodicities and polarisation properties of PSR B0031-07 for a sequence of 2700 single pulses taken simultaneously at 328 MHz and 4.85 GHz. We found that mode A occurs simultaneously at these frequencies, while modes B and C only occur at 328 MHz. However, when the pulsar is emitting in mode B at the lower frequency there is still emission at the higher frequency, hinting towards the presence of mode B emission at a weaker level. Further, we have established that modes A and B are associated with two orthogonal modes of polarisation, respectively. Based on these observations, we suggest a geometrical model where modes A and B at a given frequency are emitted in two concentric rings around the magnetic axis with mode B being nested inside mode A.
Expression of Serotonin Receptors in Human Hepatocellular Cancer

Purpose: Serotonin is a well-known neurotransmitter and vasoactive substance. Recent research indicates that serotonin contributes to liver regeneration and promotes tumor growth of human hepatocellular cancer. The aim of this study is to investigate the expression of serotonin receptors in hepatocellular cancer and analyze their potential as a cytotoxic target. Experimental Design: Using a tissue microarray and immunohistochemistry, we analyzed the expression of serotonin receptors in the liver from 176 patients with hepatocellular carcinoma, of which nontumor tissue was available in 109 patients. Relevant clinicopathologic parameters were compared with serotonin receptor expression. Two human hepatocellular cancer cell lines, Huh7 and HepG2, were used to test serotonin antagonists as a possible cytotoxic drug. Results: The serotonin receptors 1B and 2B were expressed, respectively, in 32% and 35% of the patients with hepatocellular cancer. Both receptors were associated with an increased proliferation index, and receptor 1B correlated with the size of the tumor. Serotonin antagonists of receptors 1B and 2B consistently decreased viability and proliferation in Huh7 and HepG2 cell lines. Conclusion: We identified two serotonin receptors that are often overexpressed in human hepatocellular cancer and may serve as a new cytotoxic target. Clin Cancer Res; 18(21); 5902–10. ©2012 AACR.
Transverse myelitis and acute motor sensory axonal neuropathy due to Legionella pneumophila: A case report

Guillain–Barré syndrome is a rapidly progressive symmetrical muscle weakness associated with acute inflammatory disease. Transverse myelitis (TM) is the inflammation of the spinal cord characterized by rapidly evolving muscle weakness in the lower extremities, defects in sensory level and sphincter dysfunction. Guillain–Barré syndrome, and TM association occurs very rarely in childhood. A 7‐year‐old girl presented with complaints of neck pain, spout‐style vomiting, cough, shortness of breath, and acute paraparesis with sensory and sphincter disturbance. The patient was intubated because of increased respiratory distress. A positive direct fluorescein antigen test in bronchoalveolar lavage confirmed Legionella pneumophila infection. Imaging and neurophysiologic studies were diagnostic for TM with acute motor and sensory axonal neuropathy. She was treated with a combination of high‐dose methylprednisolone and intravenous immunoglobulins, and we observed incomplete recovery. The presented case is the first child with concomitant TM and acute motor and sensory axonal neuropathy related to L. pneumophila infection.
Cognitive and Functional Deterioration in Patients with Severe COPD1

The objective of this study was to examine the association among the duration of COPD, degree of hypoxemia, and neurological abnormalities including cognitive functioning. Fifty-four patients with severe COPD and 24 age- and sex-matched controls, were included in the study. All patients and controls were administered pulmonary function tests, standardized Mini-mental State Examination (MMSE), Blessed Dementia Scale (BDS), Physical Self-maintenance Scale (PSMS), Modified Activities of Daily Living scale (MADL), Instrumental Activities of Daily Living scale (IADL), Cornell Scale for Depression in Dementia (CSDD), Global Deterioration Scale (GDS) and Clinical Dementia Rating (CDR). In addition, detailed physical and neurological examinations were performed. Sixty-four percent of patients with COPD showed abnormalities in MMSE, predominantly in recent memory, construction, attention, language, and orientation domains. Functional abnormalities were correlated with cognitive abnormalities. Although COPD patients did not show significant depression compared to controls, 77.7%. of the patients showed subjective and objective cognitive disturbance and 72.2% of the patients were classified as questionable or mild dementia. In conclusion, patients with COPD show significant cognitive and functional impairments that cannot be explained just by coincidence or by depression.
Norfloxacin versus trimethoprim-sulfamethoxazole in the therapy of uncomplicated, community-acquired urinary tract infections

In a prospective, randomized trial, norfloxacin (400 mg perorally, twice a day) was compared with trimethoprim-sulfamethoxazole (160-800 mg perorally, twice a day) in 45 patients with uncomplicated urinary tract infections. Escherichia coli was the most common isolate. Infections due to Enterobacter spp. , Proteus mirabilis, Pseudomonas spp. , and Staphylococcus spp. were also treated. Norfloxacin was equivalent in effectiveness and safety to trimethoprim-sulfamethoxazole, with a cure rate of 91% at the 5- to 9-day posttherapy visit and 88% at the 4- to 6-week posttherapy visit. It was well tolerated and had a low incidence of side effects.
zCOSMOS – 10k-bright spectroscopic sample - The bimodality in the galaxy stellar mass function: exploring its evolution with redshift

We present the Galaxy Stellar Mass Function (GSMF) up to z~1 from the zCOSMOS-bright 10k spectroscopic sample. We investigate the total MF and the contribution of ETGs and LTGs, defined by broad-band SED, morphology, spectral properties or star formation activities. We unveil a galaxy bimodality in the global MF, at least up to the z~0.55, better represented by 2 Schechter functions dominated by ETGs and LTGs, respectively. For the global population we confirm that low-mass galaxies number density increases later and faster than for massive galaxies. We find that the MF evolution at intermediate-low Mstar (logM<10.6) is mostly explained by a growth in stellar mass driven by smooth and decreasing SFHs. The low/negligible evolution at higher Mstar sets a limit of 30-15%, decreasing with redshift, to the fraction of major merging. We find that ETGs increase in number density with cosmic time faster for decreasing Mstar, with a median "building redshift" increasing with mass, in contrast with hierarchical model predictions. For LTGs we find that the number density of blue or spiral galaxies remains almost constant with cosmic time from z~1. Instead, the most extreme population of active star forming galaxies is rapidly decreasing in number density. We suggest, firstly, a transformation from blue active spiral galaxies of intermediate mass into blue quiescent and successively (1-2 Gyr after) into red passive types. The complete morphological transformation into red spheroidal galaxies, required longer time-scales or follows after 1-2 Gyr. A continuous replacement of blue galaxies is expected by low-mass active spirals growing in stellar mass. We estimate that on average ~25% of blue galaxies is transforming into red per Gyr for logM<11. We expect a negligible evolution of the global Galaxy Baryonic MF. ABRIDGED
The ELODIE survey for northern extra-solar planets - I. Six new extra-solar planet candidates

Precise radial-velocity observations at Haute-Provence Observatory (OHP, France) with the ELODIE echelle spectrograph have been undertaken since 1994. In addition to several discoveries described elsewhere, including and following that of 51 Peg b, they reveal new sub-stellar companions with essentially moderate to long periods. We report here about such companions orbiting five solar-type stars (HD 8574, HD 23596, HD 33636, HD 50554, HD 106252) and one sub-giant star (HD 190228). The companion of HD 8574 has an intermediate period of 227.55 days and a semi-major axis of 0.77 AU. All other companions have long periods, exceeding 3 years, and consequently their semi-major axes are around or above 2 AU. The detected companions have minimum masses $m_{\rm 2} \sin i$ ranging from slightly more than 2 M Jup to 10.6 M Jup . These additional objects reinforce the conclusion that most planetary companions have masses lower than 5 M Jup but with a tail of the mass distribution going up above 15 M Jup . The orbits are all eccentric and 4 out of 6 have an eccentricity of the order of 0.5. Four stars exhibit solar metallicity, one is metal-rich and one metal-poor. With 6 new extra-solar planet candidates discovered, increasing their total known to-date number to 115, the ELODIE Planet Search Survey yield is currently 18. We emphasize that 3 out of the 6 companions could in principle be resolved by diffraction-limited imaging on 8 m-class telescopes depending on the achievable contrast, and therefore be primary targets for first attempts of extra-solar planet direct imaging.
OLTP through the looking glass, and what we found there

Online Transaction Processing (OLTP) databases include a suite of features - disk-resident B-trees and heap files, locking-based concurrency control, support for multi-threading - that were optimized for computer technology of the late 1970's. Advances in modern processors, memories, and networks mean that today's computers are vastly different from those of 30 years ago, such that many OLTP databases will now fit in main memory, and most OLTP transactions can be processed in milliseconds or less. Yet database architecture has changed little. Based on this observation, we look at some interesting variants of conventional database systems that one might build that exploit recent hardware trends, and speculate on their performance through a detailed instruction-level breakdown of the major components involved in a transaction processing database system (Shore) running a subset of TPC-C. Rather than simply profiling Shore, we progressively modified it so that after every feature removal or optimization, we had a (faster) working system that fully ran our workload. Overall, we identify overheads and optimizations that explain a total difference of about a factor of 20x in raw performance. We also show that there is no single "high pole in the tent" in modern (memory resident) database systems, but that substantial time is spent in logging, latching, locking, B-tree, and buffer management operations.
Oral health as a predictive factor for oral mucositis

OBJECTIVES: Oral mucositis is a complication frequently associated with hematopoietic stem cell transplantation, decreasing a patient's quality of life and increasing the occurrence of opportunistic infections. The purpose of this study was to determine the incidence and severity of oral mucositis and to assess the correlation of this disease with the oral health of an individual at the time of hematopoietic stem cell transplantation. METHODS: Before transplantation, patients' oral health and inflammatory conditions were determined using the gingival index and the plaque index, which are based on gingival bleeding and the presence of dental plaque, respectively. Additionally, the dental health status was determined using the decayed, missing, and filled teeth index. The monitoring of oral mucositis was based on the World Health Organization grading system and was performed for five periods: from Day 0 to D+5, from D+6 to D+10, from D+11 to D+15, from D+16 to D+20, and from D+21 to D+30. RESULTS: A total of 97 patients (56% male and 44% female) who underwent hematopoietic stem cell transplantation at the Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo between January 2008 and July 2009 were prospectively examined. The incidence of ulcerative mucositis was highest from days +6 to +10 and from days +11 to +15 in the patients who underwent autologous and allogeneic hematopoietic stem cell transplantation, respectively. CONCLUSION: The data, including the dental plaque and periodontal status data, showed that these oral health factors were predictive of the incidence and severity of oral mucositis in a cohort of patients with similar conditioning regimens before hematopoietic stem cell transplantation.