Miracle-dz/UniFAR-FTUs huggingface dataset:
ANALISIS PENGARUH KEPEMIMPINAN DAN BUDAYA ORGANISASI TERHADAP KINERJA PEGAWAI DENGAN SISTEM REWARD SEBAGAI VARIABEL MODERATING

Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis pengaruh kepemimpinan dan budaya organisasi terhadap kinerja pegawai serta pengaruh sistem reward dalam hubungan antara kepemimpinan dan budaya organisasi dengan kinerja pegawai. Ppenelitian ini adalah penelitian kausal sampel 87 orang. Teknik pengumpulan data dengan menggunakan data primer berupa kuesioner.Teknik analisis data menggunakan analisa regresi linier berganda untuk menjawab tujuan penelitian pertama dan analisa regresi bertingkat untuk tujuan kedua. Hasil penelitian menunjukkan bahwa Kepemimpinan secara parsial berpengaruh signifikan terhadap Kinerja Pegawai Biro Universitas Muhammadiyah Sumatera, sedangkan Budaya Organisasi berpengaruh tidak signifikan terhadap kinerja pegawai biro UMSU. Kepemimpinan memiliki arah yang positif terhadap kinerja sedangkan Budaya Organisasi memiliki arah negatif. (2) Kepemimpinan dan Budaya Organisasi secara serempak berpengaruh terhadap kinerja pegawai biro UMSU. Kepemimpinan dan Budaya Organisasi kurang kuat untuk mempengaruhi Kinerja Pegawai Biro UMSU. (3) Sistem Reward tidak mempengaruhi hubungan antara Kepemimpinan dan Budaya Organisasi dengan Kinerja Pegawai Biro UMSU. Hal ini di mungkinkan karena Reward yang diberikan kepada pegawai biro UMSU bukan berdasarkan beban kerja namun berdasarkan masa kerja, golongan dan jabatan serta tingkat kehadiran pegawai.
First‐line therapy with thalidomide, dexamethasone and zoledronic acid decreases bone resorption markers in patients with multiple myeloma

Abstract: Background: Bone involvement is frequently observed in multiple myeloma (MM) patients both at diagnosis and during the course of the disease. The evaluation of biochemical markers of bone turnover could allow a dynamic evaluation of the effects of a given therapy on bone metabolism. Methods: In the present study, markers of bone resorption [urinary free pyridinoline (PYD), deoxypyridinoline (DPYD), N‐terminal telopeptide of collagen I (NTX) and C‐terminal telopeptide (serum crosslaps)] and of bone formation [bone alkaline phosphatase (BAP) and osteocalcin] were evaluated at diagnosis and after induction therapy in 40 patients (23M, 17F, median age = 53.5 yr) enrolled in the ‘Bologna 2002’ clinical trial. By study design, all patients received 4 months of combined thalidomide (100 mg/d for 2 wk then 200 mg/d), dexamethasone (40 mg/d on days 1–4, 9–12, 17–20/28 on odd cycles and on days 1–4 on even cycles) and zoledronic acid (4 mg/28 d). Results: At diagnosis, although bone resorption markers were increased in more than 40% of the patients, only NTX (P = 0.029) and crosslaps (P = 0.000) were significantly related to the extent of skeletal lesions, as assessed by X‐ray. After 4 months of therapy, a significant decrease in mean (±SE) urinary NTX (52.7 ±6.9 nmol/mmol creatinine ±6.9 vs. 14 ± 1.42 nmol/mmol creatinine, P = 0.000) and serum crosslaps (6242.4 ±945 pmol/L vs. 1414.9 ± 173.8 pmol/L, P = 0.000) was observed in patients obtaining ≥partial response, at variance to what has been detected in patients showing
Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: a case–control study

Background. The role of stress in the onset of chronic fatigue syndrome is unclear. Our objectives in this study were first, to determine the relation between the onset of chronic fatigue syndrome and stressful life events and difficulties. Secondly, we examined the role of a particular type of problem, dilemmas, in the onset of chronic fatigue syndrome. Method. We used a case–control design with 64 consecutive referrals from an Infectious Diseases/Liaison Psychiatry Fatigue clinic and 64 age- and sex-matched controls from a general practice population control group in Leeds. We had two main outcome measures; the odds ratios of the risk of developing chronic fatigue syndrome after experiencing a severe life event, severe difficulties or both in the year and 3 months preceding onset; and the proportion of subjects in each group who experienced a dilemma prior to onset. Results. Patients with chronic fatigue syndrome were more likely to experience severe events and difficulties in the 3 months (OR=9, 95% CI 3·2 to 25·1) and year (OR=4·3, 95% CI 1·8 to 10·2) prior to onset of their illness than population controls. In the 3 months prior to onset 19 of the 64 patients (30%) experienced a dilemma compared to none of the controls. Conclusions. Chronic fatigue syndrome is associated with stressful events and difficulties prior to onset. Those events and difficulties characterized as being dilemmas seem to be particularly important.
Neural Correlates of Ongoing Conscious Experience: Both Task-Unrelatedness and Stimulus-Independence Are Related to Default Network Activity

The default mode network (DMN) is a set of brain regions that consistently shows higher activity at rest compared to tasks requiring sustained focused attention toward externally presented stimuli. The cognitive processes that the DMN possibly underlies remain a matter of debate. It has alternately been proposed that DMN activity reflects unfocused attention toward external stimuli or the occurrence of internally generated thoughts. The present study aimed at clarifying this issue by investigating the neural correlates of the various kinds of conscious experiences that can occur during task performance. Four classes of conscious experiences (i.e., being fully focused on the task, distractions by irrelevant sensations/perceptions, interfering thoughts related to the appraisal of the task, and mind-wandering) that varied along two dimensions (“task-relatedness” and “stimulus-dependency”) were sampled using thought-probes while the participants performed a go/no-go task. Analyses performed on the intervals preceding each probe according to the reported subjective experience revealed that both dimensions are relevant to explain activity in several regions of the DMN, namely the medial prefrontal cortex, posterior cingulate cortex/precuneus, and posterior inferior parietal lobe. Notably, an additive effect of the two dimensions was demonstrated for midline DMN regions. On the other hand, lateral temporal regions (also part of the DMN) were specifically related to stimulus-independent reports. These results suggest that midline DMN regions underlie cognitive processes that are active during both internal thoughts and external unfocused attention. They also strengthen the view that the DMN can be fractionated into different subcomponents and reveal the necessity to consider both the stimulus-dependent and the task-related dimensions of conscious experiences when studying the possible functional roles of the DMN.
The Moderating Effects of Maternal Age at Childbirth and Emotion Dysregulation on the Intergenerational Continuity of Emotionally Unsupportive Parenting Behaviors

Little research has investigated factors that may moderate the intergenerational transmission of emotionally unsupportive parenting behaviors. The present study examined the role of two moderators, emotion dysregulation and maternal age at childbirth, on the relation between maternal childhood history of emotional maltreatment and current observations of emotionally unsupportive parenting behaviors in 64 mother–child dyads. Results indicated that mothers who were younger at childbirth seemed more likely to engage in emotionally unsupportive parenting behaviors in the context of high levels of sustained childhood emotional maltreatment, regardless of their level of emotion dysregulation. Mothers who were older at childbirth were at high risk for emotionally unsupportive parenting behaviors in the context of high levels of sustained emotional maltreatment histories and high emotion dysregulation, yet were not at such risk if emotion dysregulation was low. Implications for the buffering effects of emotion regulation on the risk for emotionally unsupportive behaviors were discussed.
Flatness-based fault tolerant control of a nonlinear MIMO system using algebraic derivative estimation

A flatness-based approach to fault tolerant control is proposed. The approach uses the recently published algebraic derivative estimation method for the estimation of those output derivatives that are necessary for determining intermittent actuator faults. The rapid performance of the estimation allows for an accommodation of the control to the fault. Additionally, taking into account the control saturations a novel classification scheme for actuator faults is introduced that exhibits a comprehensible graphical representation in terms of reachable sets. Dependent on the respective class of fault, an online adaptation of the reference trajectory is carried out. The ideas are demonstrated on a nonlinear MIMO system, which corresponds to an underactuated rigid body.
a 1-Acid Glycoprotein Decreases Recovery of Total Protein in Urine When Trichloroacetic Acid Is Used to Precipitate the Proteins

Total urine protein was measured in 132 samples by an automated benzethonium chloride method and the PonceauS/trichloroacetic acid (PS/TCA) method. Of these, 27% gave a result 0.1 g/L or more higher by the benzethonium chloride method. Of this 27%, most contained an abnormally high concentration of the acute-phase reactant, a1-acid glycoprotein. By assaying urine containing added a1-acid glycoprotein and albumin, we found that a1-acid glycoprotein causes the PS/TCA method to underestimate the total urine protein concentration, whereas the benzethonium chloride method is unaffected. Not allurinaryalbuminwas precipitated by TCA when a1-acid glycoprotein was present. Therefore, protein methods in which trichioroacetic acid is used as a concentrating step before the assay will underestimate total urine protein when the concentration of a1-acid glycoprotein is high.
Small incision cataract surgery and placement of posterior chamber intraocular lenses in patients with diabetic retinopathy.

BACKGROUND AND OBJECTIVE Diabetic patients undergoing cataract surgery have been demonstrated to have a guarded prognosis. Small incision cataract surgery has been postulated to cause fewer complications than other techniques of cataract extraction. We looked at small incision cataract surgery to see how diabetics fared. PATIENTS AND METHODS One hundred fifty-four eyes of diabetic patients were evaluated preoperatively through dilated fundus examination and Snellen visual acuity. The eyes then underwent small incision cataract surgery and were followed, undergoing periodic ophthalmoscopy, Snellen visual acuity measurement and additional postoperative therapeutic and surgical intervention. RESULTS Final visual acuity improved by two Snellen lines or more in 61 out of 154 (40%) eyes. Final visual acuity worsened in 38 out of 154 (25%) eyes. CONCLUSIONS Our results are similar to those reported for extracapsular surgery and phacoemulsification, suggesting that the prognosis is guarded for diabetics, even when undergoing small incision cataract surgery.
Predictors of Abnormal Bone Mass Density in Adult Patients with Homozygous Sickle-Cell Disease

Background Adult patients with sickle-cell disease (SCD) often have multiple bone compactions causing tissue hypoxia and osteonecrosis. The impact on bone abnormalities lesion detected by bone mass density is not well defined. Aim The study is a cross sectional, perspective was designed to assess the prevalence of abnormal BMD in adult Bahraini patients with SCD and to assess the predictive risk of different metabolic variables such as serum level of vitamin D3, testosterone, and parathyroid hormone in addition to lactate dehydrogenase (LDH), hemoglobin (Hb), and reticulocyte count for the development of abnormal bone density on dual X-ray absorptiometry (DXA) scan. Method The study was conducted over the period of12 months from first of January 2012 to end of December 2012. All patients were evaluated clinically for severity of SCD and abnormal bone mass density (BMD) using DXA scan. Blood samples were withdrawn for measuring the serum level of vitamin D3, testosterone, and parathyroid hormone in addition to Hb, LDH, and reticulocyte count. Multiple logistic regression analysis was used to assess risk prediction of different variables for the development of abnormal BMD on DXA with T-score ≤–2.5 standard deviation (SD). Results The study included Bahraini patients with SCD (n = 55, age 29.24 ± 9.47 years, male 60% and female 40%) compared with an age-matched healthy control group (n = 55, age 28.82 ± 8.64 years, with 62% male and 38% female). Of the 55 patients with SCD compared with the control group, there were 33 (58%) patients with low BMD and 2 (3%) in the control. Among the 33 patients with SCD and with low BMD, there were 20 (36%) with osteoporosis (T-score of ≤–2.5 SD) and 13 (24%) with osteopenia (T-score of <–1 to −2.5 SD). The most affected site of low BMD was lumbar spine (55%), followed by the radius (30%) and neck of the femur (15%). SCD patients with osteoporosis compared with the healthy subjects had significantly lower body surface area (BSA, m2) of 1.4 ± 0.3 vs. 1.63 ± 0.5 BMI, low level of vitamin D3 of 21.11 ± 6.95 ng/mL vs. 46.2 ± 15.19 (P < 0.001), lower testosterone level of 1.34 ± 0.54 vs. 2.18 ± 0.56 ng/mL (P < 0.001), higher reticulocyte count (P < 0.001), and higher LDH level (P < 0.001). The low serum level of vitamin D3 (<20 ng/mL) and low testosterone of <0.9 ng/mL had risk prediction (odds ratio) of 1.14 and 1.2, respectively, for abnormal BMD in SCD. In the risk prediction of other variables of parathormone (PTH), LDH, and reticulocyte, were not significant. Conclusion The prevalence of abnormal bone mass density (BMD) is high (60%) in Bahraini patients with SCD. There is significant low serum level of vitamin D3 and low testosterone hormone in those with very low bone mass density (BMD) (osteoporosis and T-score <–2.5). The low serum level of vitamin D3 (<20 ng/mL) and low testosterone of <0.9 ng/mL had risk prediction (odds ratio) of 1.14 and 1.2, respectively, for abnormal BMD in SCD.
The Boneh-Shaw fingerprinting scheme is better than we thought

Digital fingerprinting is a forensic method against illegal copying. The distributor marks each individual copy with a unique fingerprint. If an illegal copy appears, it can be traced back to one or more guilty pirates due to this fingerprint. To work against a coalition of several pirates, the fingerprinting scheme must be based on a collusion-secure code. This paper addresses binary collusion-secure codes in the setting of Boneh and Shaw (1995/1998). We prove that the Boneh-Shaw scheme is more efficient than originally proven, and we propose adaptations to further improve the scheme. We also point out some differences between our model and others in the literature.
Generalized Linear Models of home activity for automatic detection of mild cognitive impairment in older adults

With a globally aging population, the burden of care of cognitively impaired older adults is becoming increasingly concerning. Instances of Alzheimer's disease and other forms of dementia are becoming ever more frequent. Earlier detection of cognitive impairment offers significant benefits, but remains difficult to do in practice. In this paper, we develop statistical models of the behavior of older adults within their homes using sensor data in order to detect the early onset of cognitive decline. Specifically, we use inhomogenous Poisson processes to model the presence of subjects within different rooms throughout the day in the home using unobtrusive sensing technologies. We compare the distributions learned from cognitively intact and impaired subjects using information theoretic tools and observe statistical differences between the two populations which we believe can be used to help detect the onset of cognitive decline.
A Smart and Passive Floor-Vibration Based Fall Detector for Elderly

Falls are very prevalent among the elderly. They are the second leading cause of unintentional-injury death for people of all ages and the leading cause of death for elders 79 years and older. Studies have shown that the medical outcome of a fall is largely dependent upon the response and rescue time. Hence, a highly accurate automatic fall detector is an important component of the living setting for older adult to expedite and improve the medical care provided to this population. Though there are several kinds of fall detectors currently available, they suffer from various drawbacks. Some of them are intrusive while others require the user to wear and activate the devices, and hence may fail in the event of user non-compliance. This paper describes the working principle and the design of a floor vibration-based fall detector that is completely passive and unobtrusive to the resident. The detector was designed to overcome some of the common drawbacks of the earlier fall detectors. The performance of the detector is evaluated by conducting controlled laboratory tests using anthropomorphic dummies. The results showed 100% fall detection rate with minimum potential for false alarms
Antibodies against GD2 ganglioside can eradicate syngeneic cancer micrometastases.

After 10 years of clinical trials in patients with advanced cancer, monoclonal antibodies (mAbs) against cell surface antigens have not lived up to their initial promise. One such cell surface antigen is the ganglioside GD2. GD2 is richly expressed at the cell surfaces of human neuroblastomas, sarcomas, and melanomas. We have described a murine lymphoma (EL4) that is syngeneic in C57BL/6 mice and expresses GD2, a mAb against GD2 (mAb 3F8), and we have prepared a conjugate vaccine (GD2-keyhole limpet hemocyanin plus immunological adjuvant QS-21) that consistently induces antibodies against GD2. We demonstrate here, for the first time in a syngeneic murine model, that passively administered and vaccine-induced antiganglioside antibodies prevent outgrowth of micrometastases, and we use this model to establish some of the parameters of this protection. The level of protection was proportional to antibody titer. Treatment regimens resulting in the highest titer antibodies induced the most protection, and protection was demonstrated even when immunization was initiated after tumor challenge. Treatment with 3F8 1, 2, or 4 days after i.v. tumor challenge was highly protective, but waiting until 7 or 10 days after challenge resulted in minimal protection. The results were similar whether number of liver metastases or survival was used as the end point. These results suggest that unmodified mAbs or antibody-inducing vaccines against GD2 (and possibly other cancer cell surface antigens) should be used exclusively in the adjuvant setting, where circulating tumor cells and micrometastases are the primary targets.
RAGE signaling deficiency in rhabdomyosarcoma cells causes upregulation of PAX7 and uncontrolled proliferation

ABSTRACT Embryonal rhabdomyosarcomas (ERMSs) show elevated levels of PAX7, a transcription factor that marks quiescent adult muscle stem (satellite) cells and is important for proliferation and survival of activated satellite cells and whose timely repression is required for myogenic differentiation. However, the mechanism of PAX7 accumulation in ERMSs and whether high PAX7 causes uncontrolled proliferation in ERMS remains to be elucidated. The receptor for advanced glycation end-products (RAGE, encoded by AGER) transduces a myogenic and anti-proliferative signal in myoblasts, and stable transfection of the ERMS cell line TE671, which does not express RAGE, with AGER results in reduced proliferation and formation of tumor masses in vivo, and enhanced apoptosis and myogenic differentiation. Herein, we show that RAGE expression is low or absent in human ERMSs. We also show that in ERMS cells (1) PAX7 accumulates owing to absent or low RAGE signaling; (2) elevated PAX7 levels reduce RAGE expression and levels of MyoD and myogenin, muscle-specific transcription factors required for myoblast proliferation arrest and differentiation, respectively; (3) PAX7 supports myoblast proliferation by reducing the levels of MyoD, primarily by promoting its degradation; and (4), when ectopically expressed in ERMS cells, that RAGE upregulates myogenin which upregulates MyoD and downregulates PAX7, with consequent inhibition of proliferation and stimulation of differentiation. Thus, failure to express RAGE and, hence, MyoD and myogenin above a critical level in ERMS cells might result in deregulated PAX7 expression leading to uncontrolled proliferation and, potentially, to rhabdomyosarcomagenesis.
Back pain during different sequential treatment regimens of teriparatide: results from EUROFORS

Abstract Objective: To investigate changes in back pain in postmenopausal women with severe osteoporosis who received teriparatide for 24 months or switched at 12 months to raloxifene or no active treatment. Study design and methods: This prospective, controlled, randomised, open-label, 2-year study enrolled 868 postmenopausal women with osteoporosis and a recent fragility fracture. After 12 months of teriparatide (20 µg/day), 507 patients were randomised to further teriparatide (n = 305), raloxifene 60 mg/day (n = 100), or no active treatment (n = 102) for another 12 months (substudy 1); in substudy 2, 199 patients continued teriparatide. All received calcium and vitamin D supplementation. Back pain was self-assessed by patients using a visual analogue scale (0–100 mm). Changes in back pain were analysed using a mixed model for repeated measures. Results: During year 1, back pain decreased from a mean (SD) of 48.9 mm (24.0) at baseline by 11.5 mm (p < 0.001) in the total study population. In substudy 1, mean change in back pain from month 12 (randomisation) to 24 months was −2.2, −4.4 and +0.7 mm in the teriparatide (p = 0.076), raloxifene (p = 0.041), and no active treatment groups (p = 0.751). There were no between-group differences from randomization to 18 or 24 months. In a sensitivity analysis excluding patients with low baseline back pain (VAS < 30 mm), mean change from randomisation to endpoint was significant for teriparatide (−3.9 mm, p = 0.006) and raloxifene (−6.3 mm, p = 0.018) groups. Subgroup analyses of 503 patients who received teriparatide for up to 2 years showed that patients with a recent vertebral fracture had a greater decrease in back pain than those without (p < 0.05). Those with and without mild back pain (≥30 mm), and those with and without severe back pain (≥60 mm) at baseline all had a statistically significant reduction in back pain after 24 months (p < 0.05). Conclusions: Teriparatide treatment is associated with significant reductions in back pain regardless of the presence of recent vertebral fracture. These results need to be considered with caution due to the open-label design of the study.
Just Schools: A Whole School Approach to Restorative Justice

Foreword, Guy Masters, Wandsworth Youth Offending Team. Preface. Introduction to Restorative Justice Ideas and Practice. Guy Masters. Section 1: Introducing the Vision. 1. Restorative Justice in a School Context. 2. Bringing People on Board and Establishing the Vision. Section 2: Restorative Skills and Processes. 3. Becoming a Listening School. 4. Restorative Conversation - Talking the Talk 5. Repairing Harm Through Mediation. 6. Repairing Harm Through Restorative Conferencing. 7. Circles. Section 3: Implementation and Sustainability. 8. The Just School - A Punishment-free Zone? 9. Piecing Together the Jigsaw. Appendices. References. Useful Contacts. Index.