Miracle-dz/UniFAR-FTUs huggingface dataset:
The Evolution of Modular Product Architectures and the Emergence of Platform Ecosystems

While a large body of research has examined the advantages and disadvantages of modularity in product design, studies of modularization have tended to focus on settings in which a product’s architecture is determined by a single designer or designers within a single organization. In this paper, we ask whether modularity can arise in a decentralized setting where high-value designs are rewarded but designers’ ability to coordinate with each other and anticipate the consequences of their actions is limited—in short, whether modularity can evolve. To answer this question, we developed an agent-based model in which boundedly rational firms combine components into products. We conducted computational experiments to identify conditions that favor the emergence of products with a high degree of modularity, as measured by the extent of functional decoupling among the components. We further explored the extent to which modularity enables firms to discover high-value product designs in environments characterized by diverse or dynamic consumer preferences. Finally, we investigated the patterns of reuse among components to trace the emergence of “core” products that can become the basis for platform ecosystems. Our preliminary results support the conclusion that modularity in product design can indeed evolve, although the products generated by our model lack the defining features of real-world modular architectures (e.g., hierarchically nested subsystems and interface standards). Nonetheless, these findings can serve as a baseline for future research on the evolution of complex products and the industries that produce them.
Cyclooxygenase-2 in tumor-associated macrophages promotes metastatic potential of breast cancer cells through Akt pathway

Tumor-associated macrophages (TAMs) promote cancer development and progression by releasing various cytokines and chemokines. Previously, we have found that the number of COX-2+ TAMs was associated with lymph node metastasis in breast cancer. However, the mechanism remains enigmatic. In this study, we show that COX-2 in breast TAMs enhances the metastatic potential of breast cancer cells. COX-2 in TAMs induces MMP-9 expression and promotes epithelial-mesenchymal transition (EMT) in breast cancer cells. In addition, COX-2/PGE2 induces IL-6 release in macrophages. Furthermore, we find that the activation of Akt pathway in cancer cells is crucial for the pro-metastatic effect of COX-2+ TAMs by regulating MMP-9 and EMT. These findings indicate that TAMs facilitate breast cancer cell metastasis through COX-2-mediated intercellular communication.
Revealing the corporation : perspectives on identity, image, reputation, corporate branding, and corporate-level marketing : an anthology

Section 1: Revealing the corporation: an integrative framework 1. Managing the multiple identities of the corporation (John M. T. Balmer & Stephen A. Greyser) Section 2: Identity: the quintessence of an organization 2. Corporate identity: the myth and the reality (Wally Olins) 3. Make the most of your corporate identity (Walter Margulies) 4. Organizational identity (Stuar t Albert & David Whetten) 5. The effect of organizational structure on corporate identity management (Helen Stuart) 6. Corporate identity and corporate communications (John M. T. Balmer Edmund R. Gray) Section 3: Corporate communications: a dimension of corporate meaning 7. Corporate void (David Bernstein) 8. The management of corporate communication (Cees B. M. Van Riel) Section 4: Corporate image and reputation: the other realities 9. Sharper focus for the corporate image (Pierre Martineau) 10. Image and Substance (James Grunig) 11. The reputational landscape (Charles J. Fombrun & Cees B. M. Van Riel 12. Advancing and enhancing corporate reputation (Stephen A. Greyser) Section 5: The corporate brand: an organization's covenant 13. Brand-building in the 1990s (Stephen King) 14. The impact of corporate marketing on a company's brand extensions (Kevin Lane Keller & David A. Aaker) 15. The three virtues and seven deadly sins of corporate brand management (John M. T. Balmer) Section 6: Case Study 16. Bank one - "the uncommon partnership" (Peter L. Phillips & Stephen A. Greyser) Epilogue: beyond the age of innocence (John M. T. Balmer & Stephen A. Greyser)
On the Probability of Correct Selection for Large k Populations, with Application to Microarray Data

One frontier of modern statistical research is the problems arising from data sets with extremely large k (>1000) populations, e.g. microarray and neuroimaging data. For many such problems the focus shifts from testing for significance to selecting, filtering, or screening. Classical Ranking and Selection Methodology (RSM) studied the probability of correct selection (PCS). PCS is the probability that the “best” (t = 1) of k populations is truly selected, according to some specified criteria of best. This paper extends and adapts two selection goals from the RSM literature that are suitable for large k problems (d ‐best and G ‐best selection). It is then shown how estimation of PCS for selecting multiple (t > 1) populations with d ‐best and G ‐best selection can be implemented to provide a useful measure of the quality of a given selection. A simulation study and the application of the proposed method to a benchmark microarray data set show it is an effective and versatile tool for assessing the probability that a particular gene selection or gene filtering step truly obtains the best genes. Moreover, the proposed method is fully general and may be applied to any such extremely large k problem. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Family Resilience and Mental Illness

Abstract This paper reviews literature from psychiatry and other fields related to working with family members and introduces a potential role for occupational therapists. Historical perspectives on persons with mental illness and the burden of caregiving and family resilience are presented. Two cases illustrate how principles for enhancing family resiliency are implemented under the theoretical framework of the model of human occupation. Each family engages in a process of change that permits occupational adaptation to living with a family member who has a mental illness. The role of the occupational therapist in working with families is discussed.
Ground Thermal Diffusivity Calculation by Direct Soil Temperature Measurement. Application to very Low Enthalpy Geothermal Energy Systems

This paper presents a methodology and instrumentation system for the indirect measurement of the thermal diffusivity of a soil at a given depth from measuring its temperature at that depth. The development has been carried out considering its application to the design and sizing of very low enthalpy geothermal energy (VLEGE) systems, but it can has many other applications, for example in construction, agriculture or biology. The methodology is simple and inexpensive because it can take advantage of the prescriptive geotechnical drilling prior to the construction of a house or building, to take at the same time temperature measurements that will allow get the actual temperature and ground thermal diffusivity to the depth of interest. The methodology and developed system have been tested and used in the design of a VLEGE facility for a chalet with basement at the outskirts of Huelva (a city in the southwest of Spain). Experimental results validate the proposed approach.
The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

ABSTRACT Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression, and virus-host pathogenesis. To gain mechanistic insight into the various biological functions of Brd4, we performed a proteomic analysis to identify and characterize Brd4-associated cellular proteins. We found that the extraterminal (ET) domain, whose function has to date not been determined, interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5. These ET-domain interactions were also conserved for Brd2 and Brd3, the other human BET proteins tested. We demonstrated that GLTSCR1, NSD3, and JMJD6 impart a pTEFb-independent transcriptional activation function on Brd4. NSD3 as well as JMJD6 is recruited to regulated genes in a Brd4-dependent manner. Moreover, we found that depletion of Brd4 or NSD3 reduces H3K36 methylation, demonstrating that the Brd4/NSD3 complex regulates this specific histone modification. Our results indicate that the Brd4 ET domain through the recruitment of the specific effectors regulates transcriptional activity. In particular, we show that one of these effectors, NSD3, regulates transcription by modifying the chromatin microenvironment at Brd4 target genes. Our study thus identifies the ET domain as a second important transcriptional regulatory domain for Brd4 in addition to the carboxyl-terminal domain (CTD) that interacts with pTEFb.
The Personal and Interpersonal Benefits of Rediscovery

Individuals commonly fail to document their current experiences such that they often forget about these experiences altogether. In the context of learning, for example, experts may have difficulty remembering the experience of being inexperienced, making it difficult for them to help and train novices. Across three chapters, I explore the personal and interpersonal benefits of rediscovery—the process of revisiting past experiences that are non-salient or inaccessible in the moment. In the first chapter, I test whether individuals understand the benefits of rediscovery for themselves. Using a time capsule paradigm, I demonstrate that rediscovering past experiences, particularly ordinary ones, generates more interest and curiosity than expected. Whereas the first chapter focuses on the benefits of rediscovery at the individual level, the second and third chapters explore the interpersonal benefits of rediscovery. In the second chapter, studies with interns and medical students demonstrate that relative to relying on memories of past experiences, rediscovering these experiences (e.g., by reading their past accounts of these events) better equips individuals to understand and advise those with less experience. In the third chapter, a study of expert guitarists reveals that rediscovering the experience of inexperience enables experts to better relate to novices, helping them give advice that novices rate as more helpful and encouraging.
Generating the Torelli group

We give a new proof of the theorem of Birman-Powell that the Torelli subgroup of the mapping class group of a closed orientable surface of genus at least 3 is generated by simple homeomorphisms known as bounding pair maps. The key ingredient is a proof that the subcomplex of the curve complex of the surface spanned by curves within a fixed homology class is connected.
Yet Another Fast Multipole Method without Multipoles-Pseudoparticle Multipole Method

In this paper we describe a new approach to implement theO(N) fast multipole method andO(NlogN) tree method, which uses pseudoparticles to express the potential field. The new method is similar to Anderson's method, which uses the values of potential at discrete points to represent the potential field. However, for the same expansion order the new method is more accurate.
Contributions of gender and culture to aesthetic response.

The purpose of this study is to test and extend Parsons' (1987) theory of aesthetic development by gathering extensive data on the ways that Mexican American and Navajo females and males respond to selected art images. Studies of twelve participants, six Mexican American and six Navajo, were based on a series of semi-structured in-depth phenomenological interviews (Seidman, 1991). Participants from each culture included six male/female pairs for each of three age groups: upper elementary students, high school students and adults. Each participant responded a series of open-ended questions about a set of eleven art images. Participants described their cultural background and their own personal or educational experiences with art. The data was analyzed in several ways and used to develop a case or portrait for each participant and was compared across groups. Parsons' model with the addition of two additional stances and a rating on a naive/expert continuum was found useful in examining the ways education, experience, gender, and cultural background contributed to aesthetic responses to art images. The resulting cases should be useful in art teaching and teacher education and contribute to the literature of cases in education.
Skeletal Muscle Signaling and the Heart Rate and Blood Pressure Response to Exercise: Insight From Heart Rate Pacing During Exercise With a Trained and a Deconditioned Muscle Group

Endurance training lowers heart rate and blood pressure responses to exercise, but the mechanisms and consequences remain unclear. To determine the role of skeletal muscle for the cardioventilatory response to exercise, 8 healthy young men were studied before and after 5 weeks of 1-legged knee-extensor training and 2 weeks of deconditioning of the other leg (leg cast). Hemodynamics and muscle interstitial nucleotides were determined during exercise with the (1) deconditioned leg, (2) trained leg, and (3) trained leg with atrial pacing to the heart rate obtained with the deconditioned leg. Heart rate was ≈15 bpm lower during exercise with the trained leg (P<0.05), but stroke volume was higher (P<0.05) and cardiac output was similar. Arterial and central venous pressures, rate-pressure product, and ventilation were lower during exercise with the trained leg (P<0.05), whereas pulmonary capillary wedge pressure was similar. When heart rate was controlled by atrial pacing, stroke volume decreased (P<0.05), but cardiac output, peripheral blood flow, arterial pressures, and pulmonary capillary wedge pressure remained unchanged. Circulating [norepinephrine], [lactate] and [K+] were lower and interstitial [ATP] and pH were higher in the trained leg (P<0.05). The lower cardioventilatory response to exercise with the trained leg is partly coupled to a reduced signaling from skeletal muscle likely mediated by K+, lactate, or pH, whereas the lower cardiac afterload increases stroke volume. These results demonstrate that skeletal muscle training reduces the cardioventilatory response to exercise without compromising O2 delivery, and it can therefore be used to reduce the load on the heart during physical activity.
P-Selectin–Dependent Inhibition of Thrombosis During Venous Stasis

Leukocyte adhesion, transendothelial migration, and stasis are important components in the pathogenesis of deep vein thrombosis. Anesthetized cats were treated with saline, a recombinant soluble form of P-selectin glycoprotein ligand-1 (rPSGL-Ig), or an E- and L-selectin antibody (EL-246) before exposure and occlusion of a jugular vein. After 2 or 6 hours of occlusion, jugular veins were perfused with buffer, fixed, and prepared for scanning electron microscopy. In cats receiving saline, 2 and 6 hours of occlusion produced moderate levels of leukocyte and platelet adhesion and endothelial cell injury. Treatment of cats with rPSGL-Ig or EL-246 had no apparent effect on the magnitude of cell adhesion and endothelial cell injury compared with no treatment. After 6 hours of occlusion, the presence of a mural thrombus in untreated veins was observed and confirmed by scanning electron microscopy. Pretreatment of cats with rPSGL-Ig completely (4.0 mg/kg) or partially (1.0 mg/kg) prevented the occurrence of thrombi in the jugular veins. The reduction in thrombosis by rPSGL-Ig treatment after 6 hours of venous stasis, in the absence of any effect on leukocyte-mediated endothelial cell injury, suggests an antithrombotic mechanism of action for this protein.
Manipulating the Experienced Onset of Intention after Action Execution

Using transcranial magnetic stimulation (TMS), we have tested the time needed for the perceived onset of spontaneous motor intention to be fully determined. We found that TMS applied over the presupplementary motor area after the execution of a simple spontaneous action shifted the perceived onset of the motor intention backward in time, and shifted the perceived time of action execution forward in time. The size of the effect was similar regardless of whether TMS was applied immediately after the action or 200 msec after. The results of three control studies suggest that this effect is time-limited, specific to modality, and also specific to the anatomical site of stimulation. We conclude that the perceived onset of intention depends, at least in part, on neural activity that takes place after the execution of action. A model, which is based on the mechanism of cue integration under the presence of noise, is offered to explain the results. The implications for the conscious control of spontaneous actions are discussed.
AutoFolio : An Automatically Configured Algorithm

Algorithm selection (AS) techniques – which involve choosing from a set of algorithms the one expected to solve a given problem instance most efficiently – have substantially improved the state of the art in solving many prominent AI problems, such as SAT, CSP, ASP, MAXSAT and QBF. Although several AS procedures have been introduced, not too surprisingly, none of them dominates all others across all AS scenarios. Furthermore, these procedures have parameters whose optimal values vary across AS scenarios. This holds specifically for the machine learning techniques that form the core of current AS procedures, and for their hyperparameters. Therefore, to successfully apply AS to new problems, algorithms and benchmark sets, two questions need to be answered: (i) how to select an AS approach and (ii) how to set its parameters effectively. We address both of these problems simultaneously by using automated algorithm configuration. Specifically, we demonstrate that we can automatically configure claspfolio 2, which implements a large variety of different AS approaches and their respective parameters in a single, highly-parameterized algorithm framework. Our approach, dubbed AutoFolio, allows researchers and practitioners across a broad range of applications to exploit the combined power of many different AS methods. We demonstrate AutoFolio can significantly improve the performance of claspfolio 2 on 8 out of the 13 scenarios from the Algorithm Selection Library, leads to new state-of-the-art algorithm selectors for 7 of these scenarios, and matches state-ofthe-art performance (statistically) on all other scenarios. Compared to the best single algorithm for each AS scenario, AutoFolio achieves average speedup factors between 1.3 and 15.4.
Interactions of borderline personality disorder and mood disorders over 10 years.

OBJECTIVE To examine the relationship of borderline personality disorder (BPD) to mood disorders by using data from the Collaborative Longitudinal Personality Disorders Study on the reciprocal interactions of BPD with both depressive and bipolar disorders over the course of 10 years. METHOD The study included 223 BPD patients with DSM-IV-defined co-occurring major depressive disorder (MDD) (n = 161), bipolar I disorder (n = 34), and bipolar II disorder (n = 28) who were reliably and prospectively assessed over a period of 10 years between 1997 and 2009. Proportional hazards regression analyses were used to assess the effects of improvement or worsening of BPD and mood disorders on each disorder's time to remission and time to relapse. RESULTS Borderline personality disorder and MDD had strong and statistically significant reciprocal effects, delaying each disorder's time to remission (BPD's effect on MDD, P = .0004; MDD's effect on BPD, P = .0002) and accelerating time to relapse (BPD's effect on MDD, P = .0410; MDD's effect on BPD, P = .0011), whereas BPD and the bipolar disorders were largely independent disorders except that bipolar II lengthened BPD's time to remission (P = .0085). CONCLUSIONS Borderline personality disorder and MDD interactions suggest overlap in their psychopathologies and argue for prioritizing the treatment of BPD. Borderline personality disorder and bipolar disorders appear to be independent disorders, underscoring the need to provide appropriate treatment for each.
LES APPROCHES D'EVALUATION ET LES INDICATEURS DE MESURE DE LA QUALITE D'AUDIT: UNE REVUE CRITIQUE

Les recents scandales financiers ont montre l'incapacite des approches classiques et leurs indicateurs de mesure a evaluer la pertinence des travaux d'audit menes. Celle-ci debouche sur la necessite de developpement de nouvelles approches plutot directes d'evaluation de la qualite d'audit et sur la mobilisation de nouvelles methodologies empiriques permettant de mieux capter la complexite des travaux d'audit realises. L'objectif de ce papier est de mener une etude critique des differentes approches d'evaluation et des indicateurs de mesure de la qualite d'audit. Nous proposons a ce titre de faire le tour d'horizon des differents travaux effectues en la matiere en les structurant selon une typologie appropriee
Unified simulation evaluation for mobile broadband technologies

System-level simulation has been widely used to evaluate system performance. Simulation methodologies have also been comprehensively discussed in different organizations or institutions. Most of the simulation methodologies proposed, however, mainly focus on one area of specific technologies. How to evaluate the performance of multiple air interface systems (e.g., cdma2000, WCDMA, WiMAX, and their evolutions) in a fair and comprehensive manner has not been addressed extensively. This article presents a unified simulation methodology, including fading channel models, system configurations, and how to consider technology-dependent algorithms such as scheduling, overhead modeling, interference margin definition, and resource allocation based on system loading. This article uses this framework to compare three major existing radio technologies: cdma2000 1x EV-DO Rev. A, WCDMA HSPA, and mobile WiMAX based on 802.16e. Key simulation results based on our suggested system models and settings are presented and analyzed. It is shown that under our unified framework, the two CDMA systems exhibit higher spectrum efficiency than mobile WiMAX, especially on the downlink, while mobile WiMAX provides a higher peak rate.
Oligomycin Induces a Decrease in the Cellular Content of a Pathogenic Mutation in the Human Mitochondrial ATPase 6 Gene*

A T → G mutation at position 8993 in human mitochondrial DNA is associated with the syndrome neuropathy, ataxia, and retinitis pigmentosa and with a maternally inherited form of Leigh’s syndrome. The mutation substitutes an arginine for a leucine at amino acid position 156 in ATPase 6, a component of the F0 portion of the mitochondrial ATP synthase complex. Fibroblasts harboring high levels of the T8993G mutation have decreased ATP synthesis activity, but do not display any growth defect under standard culture conditions. Combining the notions that cells with respiratory chain defects grow poorly in medium containing galactose as the major carbon source, and that resistance to oligomycin, a mitochondrial inhibitor, is associated with mutations in the ATPase 6 gene in the same transmembrane domain where the T8993G amino acid substitution is located, we created selective culture conditions using galactose and oligomycin that elicited a pathological phenotype in T8993G cells and that allowed for the rapid selection of wild-type over T8993G mutant cells. We then generated cytoplasmic hybrid clones containing heteroplasmic levels of the T8993G mutation, and showed that selection in galactose-oligomycin caused a significant increase in the fraction of wild-type molecules (from 16 to 28%) in these cells.