Miracle-dz/UniFAR-FTUs huggingface dataset:
Potential Impacts of Climate Change on Water Resources in the Kunhar River Basin, Pakistan

Pakistan is one of the most highly water-stressed countries in the world and its water resources are greatly vulnerable to changing climatic conditions. The present study investigates the possible impacts of climate change on the water resources of the Kunhar River basin, Pakistan, under A2 and B2 scenarios of HadCM3, a global climate model. After successful development of the hydrological modeling system (HEC-HMS) for the basin, streamflow was simulated for three future periods (2011–2040, 2041–2070, and 2071–2099) and compared with the baseline period (1961–1990) to explore the changes in different flow indicators such as mean flow, low flow, median flow, high flow, flow duration curves, temporal shift in peaks, and temporal shifts in center-of-volume dates. From the results obtained, an overall increase in mean annual flow was projected in the basin under both A2 and B2 scenarios. However, while summer and autumn showed a noticeable increase in streamflow, spring and winter showed decreased streamflow. High and median flows were predicted to increase, but low flow was projected to decrease in the future under both scenarios. Flow duration curves showed that the probability of occurrence of flow is likely to be more in the future. It was also noted that peaks were predicted to shift from June to July in the future, and the center-of-volume date—the date at which half of the annual flow passes—will be delayed by about 9–17 days in the basin, under both A2 and B2 scenarios. On the whole, the Kunhar basin will face more floods and droughts in the future due to the projected increase in high flow and decrease in low flow and greater temporal and magnitudinal variations in peak flows. These results highlight how important it is to take cognizance of the impact of climate change on water resources in the basin and to formulate suitable policies for the proper utilization and management of these resources.
Racial and ethnic differences in the transition to a teenage birth in the United States.

CONTEXT Rates of teenage childbearing are high in the United States, and they differ substantially by race and ethnicity and nativity status. METHODS Data from the National Longitudinal Survey of Youth 1997 cohort were used to link characteristics of white, black, U.S.-born Hispanic and foreign-born Hispanic adolescents to teenage childbearing. Following a sample of 3,294 females aged 12-16 through age 19, discrete-time logistic regression analyses were used to examine which domains of teenagers' lives were associated with the transition to a teenage birth for each racial and ethnic group, and whether these associations help explain racial and ethnic and nativity differences in this transition. RESULTS In a baseline multivariate analysis controlling for age, compared with whites, foreign-born Hispanics had more than three times the odds of a teenage birth (odds ratio, 3.5), while blacks and native-born Hispanics had about twice the odds (2.1 and 1.9, respectively). Additional controls (for family environments; individual, peer and dating characteristics; characteristics of first sexual relationships; and subsequent sexual experience) reduced the difference between blacks and whites, and between foreign-born Hispanics and whites, and eliminated the difference between U.S.-born Hispanics and whites. Further, if racial or ethnic minority adolescents had the same distribution as did white teenagers across all characteristics, the predicted probability of a teenage birth would be reduced by 40% for blacks and 35% for U.S.-born Hispanics. CONCLUSIONS Differences in the context of adolescence may account for a substantial portion of racial, ethnic and nativity differences in teenage childbearing.
Nutritional Keys for Intestinal Barrier Modulation

The intestinal tract represents the largest interface between the external environment and the human body. Nutrient uptake mostly happens in the intestinal tract, where the epithelial surface is constantly exposed to dietary antigens. Since inflammatory response toward these antigens may be deleterious for the host, a plethora of protective mechanisms take place to avoid or attenuate local damage. For instance, the intestinal barrier is able to elicit a dynamic response that either promotes or impairs luminal antigens adhesion and crossing. Regulation of intestinal barrier is crucial to control intestinal permeability whose increase is associated with chronic inflammatory conditions. The cross talk among bacteria, immune, and dietary factors is able to modulate the mucosal barrier function, as well as the intestinal permeability. Several nutritional products have recently been proposed as regulators of the epithelial barrier, even if their effects are in part contradictory. At the same time, the metabolic function of the microbiota generates new products with different effects based on the dietary content. Besides conventional treatments, novel therapies based on complementary nutrients are now growing. Fecal therapy has been recently used for the clinical treatment of refractory Clostridium difficile infection instead of the classical antibiotic therapy. In the present review, we will outline the epithelial response to nutritional components derived from dietary intake and microbial fermentation focusing on the consequent effects on the integrity of the epithelial barrier.
Cognitive performance before and after kidney transplantation: A prospective controlled study of adequately dialyzed patients with end-stage renal disease

Abstract Patients with end-stage renal disease (ESRD) who receive dialysis have been shown to have impaired neuropsychological performance. It remains unclear, however, whether cognitive deficits associated with ESRD and/or dialysis are reversible after successful kidney transplantation. Thus, the main purpose of this study was to longitudinally compare the cognitive performance of adequately dialyzed patients with ESRD before and shortly after kidney transplantation. Twenty-two dialyzed patients with ESRD who subsequently received a kidney transplant, 20 dialyzed patients who were medically qualified and awaiting kidney transplant but did not receive it, and 30 matched controls were the participants for this study. Overall, our results demonstrate that a successful kidney transplant is associated with improved neuropsychological performance in patients with ESRD. Specifically, a significant improvement was seen on measures of psychomotor speed, visual planning, retrieval of learnt material, and abstract thinking. Additionally, the degree of cognitive improvement following kidney transplant was significantly associated with some pre-, intra-, and postoperative factors (e.g., age, duration of chronic kidney disease, postoperative graft function). The results of this study also show that the cognitive performance of adequately dialyzed patients without a kidney transplant, although often below that of matched controls, remains relatively stable over time . (JINS, 2009, 15, 684–694.)
GSK3β-Dzip1-Rab8 Cascade Regulates Ciliogenesis after Mitosis

The primary cilium, which disassembles before mitotic entry and reassembles after mitosis, organizes many signal transduction pathways that are crucial for cell life and individual development. However, how ciliogenesis is regulated during the cell cycle remains largely unknown. Here we show that GSK3β, Dzip1, and Rab8 co-regulate ciliogenesis by promoting the assembly of the ciliary membrane after mitosis. Immunofluorescence and super-resolution microscopy showed that Dzip1 was localized to the periciliary diffusion barrier and enriched at the mother centriole. Knockdown of Dzip1 by short hairpin RNAs led to failed ciliary localization of Rab8, and Rab8 accumulation at the basal body. Dzip1 preferentially bound to Rab8GDP and promoted its dissociation from its inhibitor GDI2 at the pericentriolar region, as demonstrated by sucrose gradient centrifugation of purified basal bodies, immunoprecipitation, and acceptor-bleaching fluorescence resonance energy transfer assays. By means of in vitro phosphorylation, in vivo gel shift, phospho-peptide identification by mass spectrometry, and GST pulldown assays, we demonstrated that Dzip1 was phosphorylated by GSK3β at S520 in G0 phase, which increased its binding to GDI2 to promote the release of Rab8GDP at the cilium base. Moreover, ciliogenesis was inhibited by overexpression of the GSK3β-nonphosphorylatable Dzip1 mutant or by disabling of GSK3β by specific inhibitors or knockout of GSK3β in cells. Collectively, our data reveal a unique cascade consisting of GSK3β, Dzip1, and Rab8 that regulates ciliogenesis after mitosis.
The design and discovery of T-type calcium channel inhibitors for the treatment of central nervous system disorders

Introduction: Neuronal T-type calcium channels (T-type channels) are expressed throughout the central nervous system (CNS), regulating neuronal excitability. T-type channels in the CNS are involved in various neurophysiological and pathophysiological states, and thus have become a promising therapeutic target. Areas covered: This article discusses T-type channel-related CNS disorders such as epilepsy, neuropathic pain, insomnia and tremor disorders including Parkinson's disease. In addition, the article reviews T-type channel inhibitors showing efficacy in animal models in such CNS disorders, with a focus on classical T-type channel inhibitors with limited specificity for T-type channels as well as novel inhibitors with high specificity. Furthermore, the article also presents and discusses the next generation of T-type channel inhibitor discovery, virtual as well as screening and high-throughput screening techniques. Expert opinion: Although T-type channel-related CNS disorders seem to be diverse, it converges into the one major cause – abnormal hyperactivity of neurons. T-type channel-specific inhibitors could thus be commonly applied for the treatment of such CNS disorders regardless of the complexity of individual disorder. Structural information of inhibitor-binding sites would facilitate the discovery of the next generation of T-type channel-specific inhibitors by stimulating structure-based rational drug designs.
Deployment of Attention on Handshakes

Understanding the social structures between objects, organizing, and selecting them accordingly, is fundamental to social cognition. We report an example that demonstrates the object association learned from social interactions could impact visual attention. Particularly, when two hands approach each other to perform a handshake, they tend to be attended to as a unit because of the cooperative relationship exhibited in the action: even a cue presented on a non-target hand may facilitate a response to the targets that appear on the non-cued hand (Experiment 1), indicating that attentional shift between two hands was facilitated; furthermore, the response to a target on one hand is significantly impaired by a distractor on the other hand (Experiment 2), implying that it is difficult to selectively confine attention to a single hand. These effects were dependent on the existence of the hands when cue and target appeared (Experiment 3); neither perceptual familiarity, or physical fit can explain all the attention effects (Experiment 4). These results have bearings on the perceptual root of social cognition.
Finite-time consensus for heterogeneous multi-agent systems with mixed-order agents

This paper studies the finite-time consensus for heterogeneous multi-agent systems composed of mixed-order agents over fixed and switching topologies. The control protocol of each agent using local information is designed and the detailed analysis of the finite-time consensus for fixed and switching interaction topologies is presented. The design of the finite-time consensus protocol is based on graph theory, matrix theory, and LaSalle’s invariance principle. Both theoretical studies and simulation results show the effectiveness of the proposed method and the correctness of the obtained theoretical results.
Symmetric Systems and their Applications to Root Systems Extended by Abelian Groups

We investigate the class of root systems R obtained by extending an irreducible root system by a torsion-free group G. In this context there is a Weyl group W and a group U with the presentation by conjugation. We show under additional hypotheses that the kernel of the natural homomorphism from U to W is isomorphic to the kernel of the homomorphism from the abelianization of U to that of W. For this we introduce the concept of a symmetric system, a discrete version of the concept of a symmetric space. Mathematics Subject Classification 2000: 20F55, 17B65, 17B67, 22E65, 22E40. Key Words and Phrases: Weyl group, root system, presentation by conjugation, extended affine Weyl group (EAWeG), extended affine root system (EARS), irreducible root system extended by an abelian group.
A Theory of Urban Squatting and Land-Tenure Formalization in Developing Countries

This paper offers a new theoretical approach to urban squatting, reflecting the view that squatters and formal residents compete for land within a city. The key implication of this view is that squatters ``squeeze" the formal market, raising the price paid by formal residents. The squatter organizer, however, ensures that this squeezing is not too severe, since otherwise the formal price will rise to a level that invites eviction by landowners (defensive expenditures by squatter households also help to forestall eviction). Because eviction is thus absent in equilibrium, the model differs crucially from previous analytical frameworks, where eviction occurs with some probability.
The Resonant Damping of Fast Magnetohydrodynamic Oscillations in a System of Two Coronal Slabs

Observations of transverse coronal loop oscillations very often show the excitation and damping of oscillations in groups of coronal loops rather than in individual and isolated structures. We present results on the oscillatory properties (periods, damping rates, and spatial distribution of perturbations) for resonantly damped oscillations in a system of two inhomogeneous coronal slabs and compare them to the properties found in single-slab loop models. A system of two identical coronal loops is modeled, in Cartesian geometry, as being composed of two density enhancements. The linear magnetohydrodynamic (MHD) wave equations for oblique propagation of waves are solved, and the damping of the different solutions, due to the transverse inhomogeneity of the density profile, is computed. The physics of the obtained results is analyzed by an examination of the perturbed physical variables. We find that, due to the interaction between the loops, the normal modes of oscillation present in a single slab split into symmetric and antisymmetric oscillations when a system of two identical slabs is considered. The frequencies of these solutions may differ from the single slab results when the distance between the loops is of the order of a few slab widths. Oblique propagation of waves weakens this interaction, since solutions become more confined to the edges of the slabs. The damping is strong for surface-like oscillations, while sausage body-like solutions are unaffected. For some solutions, and small slab separations, the damping in a system of two loops differs substantially from the damping of a single loop.
Changes in the episodic memory and executive functions of abstinent and relapsed alcoholics over a 6-month period.

BACKGROUND It is still unclear whether episodic memory and executive functions capacities can return to normal in abstinent patients over a 6-month period. Furthermore, the role of interim drinking in cognitive recovery is still not well known. Finally, further research is required to specify the predictive value of cognitive abilities at initial testing in the treatment outcome (abstinence or relapse). The aims of the present study were therefore to measure changes in episodic memory and executive functions over a 6-month period in abstinent and relapsed alcoholics and to ascertain whether neuropsychological results at treatment entry can predict treatment outcome at follow-up. METHODS Fifty-four alcoholic patients and 54 matched control subjects performed baseline neuropsychological tasks assessing episodic memory, executive functions, the slave systems of working memory and attentional abilities. At the follow-up session (i.e., 6 months later), episodic memory and 3 executive functions (inhibition, flexibility, and updating) were re-examined in the alcoholic patients. RESULTS Results showed that over the 6-month interval, the abstainers' episodic memory and executive performances had returned to normal, whereas the relapsers performed lower than before in the flexibility task. Episodic memory and executive functions recovery was correlated, in abstainers, with drinking history and age respectively. Finally, there was no significant difference regarding neuropsychological scores at baseline between abstainers and relapsers. DISCUSSION Over the 6-month interval, abstainers normalized episodic memory and executive performances whereas relapsers obtained executive results which were more severely impaired, emphasizing the influence of interim drinking on cognitive changes. Episodic memory, executive functions, the slave systems of working memory and attentional abilities did not appear to be reliable predictors of treatment outcome over a 6-month interval.
High basal defense gene expression determines sorghum resistance to the whorl‐feeding insect southwestern corn borer

Southwestern corn borer (SWCB, Diatraea grandiosella) and fall armyworm (FAW, Spodoptera frugiperda) are major pests of sorghum in the southern United States. Host plant resistance is a desirable means for reducing plant damage and yield losses from both insects. In this study, we evaluated 12 sorghum lines for whorl‐stage resistance to leaf‐feeding SWCB and FAW in greenhouse and laboratory bioassays. Differential plant responses were detected against the two insects. Among 12 lines tested, CM1821, Della and PI196583 were resistant to both insects, while BTx2752 was largely susceptible. Line R.09110 was resistant to SWCB, but susceptible to FAW, whereas Redbine‐60 was susceptible to SWCB, but not to FAW. In addition, we quantified various chemical components in the plants and determined their association with insect resistance. Tannin and chlorophyll in leaves did not show any significant correlation with resistance to either insects, but contents of soluble protein in general were negatively correlated with resistance to both insects. Endogenous soluble sugar and dhurrin were only positively correlated with resistance to SWCB, but not with FAW resistance. To gain some molecular insight into resistance mechanism of sorghum to SWCB, we performed qPCR reactions for key genes encoding enzymes involved in dhurrin and jasmonic acid (JA) biosynthesis on selected resistant or susceptible lines. Although these genes were rapidly and strongly induced by insect feeding in all lines, the observed resistance is likely explained by higher constitutive dhurrin contents in some resistant lines and higher basal JA biosynthesis in others. Our results suggest that sorghum utilizes multiple strategies to defend itself against SWCB.
Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos

Background. ABO hemolytic disease of the newborn is the most common hemolytic consequence of maternofetal blood group incompatibility restricted mostly to non-group-O babies of group O mothers with immune anti-A or anti-B antibodies. Aim. We estimated the risk of ABO HDN with view to determining need for routine screening for ABO incompatibility between mother and fetus. Materials and Methods. Prevalence of ABO blood group phenotypes in blood donors at the donor clinic of the Lagos University Teaching Hospital and arithmetic methods were used to determine population prevalence of ABO genes. We then estimated proportion of pregnancies of group O mothers carrying a non-group-O baby and the risk that maternofetal ABO incompatibility will cause clinical ABO HDN. Results. Blood from 9138 donors was ABO typed. 54.3%, 23%, 19.4%, and 3.3% were blood groups O, A, B, and AB, respectively. Calculated gene frequencies were 0.1416, 0.1209, and 0.7375 for A, B, and O genes, respectively. It was estimated that 14.3% of deliveries will result in a blood group O woman giving birth to a child who is non-group-O. Approximately 4.3% of deliveries are likely to suffer ABO HDN with 2.7% prone to suffer from moderately severe to severe hemolysis.
An anisotropic unified nonlinear strength criterion (AUNS) for geomaterials

Abstract Due to depositional processes and other factors, such as shear banding and the intermediate principal stress, soils and rocks are typically cross-anisotropic. Strength anisotropy should be described by the proper anisotropic strength criterion. This paper presents an anisotropic unified nonlinear strength criterion to accurately characterize the strength anisotropy of geomaterials based on a unified nonlinear strength criterion (UNS). The anisotropic state variable in terms of a joint invariant and a unit stress tensor is brought into the UNS criterion to characterize the effect of the anisotropy. The new criterion had been illustrated in both the meridian and octahedral planes, leading it the oversimplification to describe strength anisotropy behaviors of soils and rocks under different loading conditions. Moreover, only conventional triaxial test is employed to calibrate the parameters of the new criterion. The results demonstrated the ability of the anisotropic strength criterion to be applied to a wide range of soils and rocks for true triaxial tests along with the complex stress condition in torsion shear tests. By comparing the predictions to test results reported in the literature, the new criterion proposed in this paper is able to provide excellent traits of the strength anisotropy for various geomaterials.
Differential Effects of Semantic and Identity Priming in Patients with Left and Right Hemisphere Lesions

Patients with single brain lesions in the anterior or posterior left and right hemispheres and a group of controls were studied in two priming experiments. The first experiment employed associative pairs (DOCTOR-NURSE) and the second employed identical pairs (NURSE-nurse). Short and long prime-target stimulus onset asynchronies (SOAs) (i.e., 250 and 1850 msec) were manipulated within block in both experiments. In the first experiment, patients with left hemisphere injury showed a deficient priming effect while patients with right hemisphere injury and controls showed a normal pattern. In contrast, all groups showed an identity priming effect in the second experiment. These results indicate that while entries in the mental lexicon are available for the groups of patients studied, the spread of activation to related concepts in this lexicon is disrupted in the left hemisphere-damaged group.