Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparison of single column model simulations of summertime midlatitude continental convection

Eleven different single-column models (SCMs) and one cloud ensemble model (CEM) are driven by boundary conditions observed at the Atmospheric Radiation Measurement (ARM) program southern Great Plains site for a 17 day period during the summer of 1995. Comparison of the model simulations reveals common signatures identifiable as products of errors in the boundary conditions. Intermodel differences in the simulated temperature, humidity, cloud, precipitation, and radiative fluxes reflect differences in model resolution or physical parameterizations, although sensitive dependence on initial conditions can also contribute to intermodel differences. All models perform well at times but poorly at others. Although none of the SCM simulations stands out as superior to the others, the simulation by the CEM is in several respects in better agreement with the observations than the simulations by the SCMs. Nudging of the simulated temperature and humidity toward observations generally improves the simulated cloud and radiation fields as well as the simulated temperature and humidity but degrades the precipitation simulation for models with large temperature and humidity biases without nudging. Although some of the intermodel differences have not been explained, others have been identified as model problems that can be or have been corrected as a result of the comparison.
Developing Brand Relationships after a Brand Transgression: The Role of Implicit Theories of Relationships

Prior research finds that strong consumer-brand relationships buffer the potentially negative consequences of brand transgressions, but weak consumer-brand relationships fail to do so. We reconsider these findings regarding weak consumer-brand relationships. Results from three studies show that consumers with weak brand relationships can actually become more engaged and more emotionally attached to a brand after a brand transgression, depending on their implicit beliefs about relationships. If they believe that successful relationships grow through the partners’ mutual efforts to resolve problems and overcome obstacles, they can develop stronger relationships with a brand after a brand transgression.
Victims' Time Discounting 2.5 Years after the Wenchuan Earthquake: An ERP Study

Background Time discounting refers to the fact that the subjective value of a reward decreases as the delay until its occurrence increases. The present study investigated how time discounting has been affected in survivors of the magnitude-8.0 Wenchuan earthquake that occurred in China in 2008. Methodology Nineteen earthquake survivors and 22 controls, all school teachers, participated in the study. Event-related brain potentials (ERPs) for time discounting tasks involving gains and losses were acquired in both the victims and controls. Findings The behavioral data replicated our previous findings that delayed gains were discounted more steeply after a disaster. ERP results revealed that the P200 and P300 amplitudes were increased in earthquake survivors. There was a significant group (earthquake vs. non- earthquake) × task (gain vs. loss) interaction for the N300 amplitude, with a marginally significantly reduced N300 for gain tasks in the experimental group, which may suggest a deficiency in inhibitory control for gains among victims. Conclusions The results suggest that post-disaster decisions might involve more emotional (System 1) and less rational thinking (System 2) in terms of a dual-process model of decision making. The implications for post-disaster intervention and management are also discussed.
Automatic Postural Responses Are Delayed by Pyridoxine-Induced Somatosensory Loss

Pyridoxine given in large doses is thought to destroy selectively the large-diameter peripheral sensory nerve fibers, leaving motor fibers intact. This study examined the effects of pyridoxine-induced somatosensory loss on automatic postural responses to sudden displacements of the support surface in the standing cat. Two cats were trained to stand on four force plates mounted on a movable platform. They were given pyridoxine (350 mg/kg, i.p.) on 2 successive days (0 and 1). Electromyographic (EMG) activity was recorded from selected hindlimb muscles during linear ramp-and-hold platform displacements in each of 12 directions at 15 cm/sec. In control trials onset latencies of evoked activity in hindlimb flexor and extensor muscles ranged from 40 to 65 msec after the onset of platform acceleration. After injection the EMG latencies increased over days, becoming two to three times longer than controls by day 7. Excursions of the body center of mass (CoM) in the direction opposite to that of platform translation were significantly greater at day 7 compared with controls, and the time at which the CoM subsequently reversed direction was delayed. Both animals were ataxic from day 2 onward. Histological analysis of cutaneous and muscle nerves in the hindlimb revealed a significant loss of fibers in the group I range. Our results suggest that large afferent fibers are critical for the timing of automatic postural responses to ensure coordinated control of the body CoM and balance after unexpected disturbances of the support surface.
Sex differences and parallels in the development of externalizing behaviours in childhood: Boys’ and girls’ susceptibility to social preference among peers

Abstract This study examined whether being poorly preferred by peers may partially explain why boys with oppositional behaviour develop more conduct problems than girls. Children from the general Dutch population attending regular elementary schools (N = 759, 50.3% boys) were followed annually from age 7 to 10 years. Teachers-rated externalizing behaviour and peer-nominated social preference was assessed across four waves. Autoregressive cross-lagged models indicated that oppositionality predicted increases in conduct problems. Above and beyond this direct link, oppositionality predicted low social preference in subsequent years, which in turn predicted an increase in conduct problems. In this latter pathway, sex differences were found. That is, oppositional boys were as likely as oppositional girls to show an increase in low social preference one year later. However, boys who had low social preference scores showed stronger increases in conduct problems one year later, compared to girls who had low social preference scores. Hence, developmental models of externalizing behaviour should consider the possible sex-differential impact of troublesome peer-relationships to understand the development of milder to more severe externalizing behaviours.
HMG-CoA Reductase Inhibitors Improve Acute Ischemic Stroke Outcome

Background and Purpose— Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored. Methods— We assessed potential effects of statins initiated before or within 4 weeks of stroke on 90-day outcome. Favorable outcomes were National Institutes of Health Stroke Scale (NIHSS) score ≤2 at 12 weeks and modified Rankin Scale (mRS) ≤2. Results— Before stroke, 129 patients were receiving statins, 123 initiated statins within 4 weeks, and 600 patients were not on statins. Multivariate logistic regression analysis demonstrated that poststroke statins were associated with a significant probability of a favorable outcome at 12 weeks [NIHSS (P=0.002; OR, 1.92; CI, 1.27 to 2.91) and mRS (P=0.033; OR, 1.57; CI, 1.04 to 2.38)], whereas prestroke statins demonstrated a trend toward significance. Conclusions— These preliminary results suggest that statin use may improve outcome of acute ischemic stroke.
Fine-grained DVFS using on-chip regulators

Limit studies on Dynamic Voltage and Frequency Scaling (DVFS) provide apparently contradictory conclusions. On the one hand early limit studies report that DVFS is effective at large timescales (on the order of million(s) of cycles) with large scaling overheads (on the order of tens of microseconds), and they conclude that there is no need for small overhead DVFS at small timescales. Recent work on the other hand—motivated by the surge of on-chip voltage regulator research—explores the potential of fine-grained DVFS and reports substantial energy savings at timescales of hundreds of cycles (while assuming no scaling overhead). This article unifies these apparently contradictory conclusions through a DVFS limit study that simultaneously explores timescale and scaling speed. We find that coarse-grained DVFS is unaffected by timescale and scaling speed, however, fine-grained DVFS may lead to substantial energy savings for memory-intensive workloads. Inspired by these insights, we subsequently propose a fine-grained microarchitecture-driven DVFS mechanism that scales down voltage and frequency upon individual off-chip memory accesses using on-chip regulators. Fine-grained DVFS reduces energy consumption by 12% on average and up to 23% over a collection of memory-intensive workloads for an aggressively clock-gated processor, while incurring an average 0.08% performance degradation (and at most 0.14%). We also demonstrate that the proposed fine-grained DVFS mechanism is orthogonal to existing coarse-grained DVFS policies, and further reduces energy by 6% on average and up to 11% for memory-intensive applications with limited performance impact (at most 0.7%).
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

BACKGROUND In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia. Patients have a response to immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% of the patients, usually many months to years after the diagnosis of aplastic anemia. METHODS We performed next-generation sequencing and array-based karyotyping using 668 blood samples obtained from 439 patients with aplastic anemia. We analyzed serial samples obtained from 82 patients. RESULTS Somatic mutations in myeloid cancer candidate genes were present in one third of the patients, in a limited number of genes and at low initial variant allele frequency. Clonal hematopoiesis was detected in 47% of the patients, most frequently as acquired mutations. The prevalence of the mutations increased with age, and mutations had an age-related signature. DNMT3A-mutated and ASXL1-mutated clones tended to increase in size over time; the size of BCOR- and BCORL1-mutated and PIGA-mutated clones decreased or remained stable. Mutations in PIGA and BCOR and BCORL1 correlated with a better response to immunosuppressive therapy and longer and a higher rate of overall and progression-free survival; mutations in a subgroup of genes that included DNMT3A and ASXL1 were associated with worse outcomes. However, clonal dynamics were highly variable and might not necessarily have predicted the response to therapy and long-term survival among individual patients. CONCLUSIONS Clonal hematopoiesis was prevalent in aplastic anemia. Some mutations were related to clinical outcomes. A highly biased set of mutations is evidence of Darwinian selection in the failed bone marrow environment. The pattern of somatic clones in individual patients over time was variable and frequently unpredictable. (Funded by Grant-in-Aid for Scientific Research and others.).
Xenopus Drf1, a Regulator of Cdc7, Displays Checkpoint-dependent Accumulation on Chromatin during an S-phase Arrest*

We have cloned a Xenopus Dbf4-related factor named Drf1 and characterized this protein by using Xenopus egg extracts. Drf1 forms an active complex with the kinase Cdc7. However, most of the Cdc7 in egg extracts is not associated with Drf1, which raises the possibility that some or all of the remaining Cdc7 is bound to another Dbf4-related protein. Immunodepletion of Drf1 does not prevent DNA replication in egg extracts. Consistent with this observation, Cdc45 can still associate with chromatin in Drf1-depleted extracts, albeit at significantly reduced levels. Nonetheless, Drf1 displays highly regulated binding to replicating chromatin. Treatment of egg extracts with aphidicolin results in a substantial accumulation of Drf1 on chromatin. This accumulation is blocked by addition of caffeine and by immunodepletion of either ATR or Claspin. These observations suggest that the increased binding of Drf1 to aphidicolin-treated chromatin is an active process that is mediated by a caffeine-sensitive checkpoint pathway containing ATR and Claspin. Abrogation of this pathway also leads to a large increase in the binding of Cdc45 to chromatin. This increase is substantially reduced in the absence of Drf1, which suggests that regulation of Drf1 might be involved in the suppression of Cdc45 loading during replication arrest. We also provide evidence that elimination of this checkpoint causes resumed initiation of DNA replication in both Xenopus tissue culture cells and egg extracts. Taken together, these observations argue that Drf1 is regulated by an intra-S-phase checkpoint mechanism that down-regulates the loading of Cdc45 onto chromatin containing DNA replication blocks.
Cohort differences and chronic disease profiles of differential disability trajectories.

OBJECTIVES Research shows declining disability rates, but little is known about whether cohort differences are due to delayed onset, increased recovery, or reduced severity of impairment. Furthermore, disease is considered the proximate cause of disability yet chronic conditions rates are increasing, making it unclear whether the conditions predicting specific disability trajectories are changing. METHODS We use a latent class analysis of disability trajectories and corresponding mortality with three birth cohorts of the National Long-Term Care Survey to determine how long-term experiences of disablement differ by cohort and chronic conditions. RESULTS More recent cohorts were more likely to experience a decade free of disablement compared with all other disability trajectories. Sensory problems and hypertension correspond to trajectories of non-disablement, whereas hip fracture, stroke, arthritis, and diabetes predict more disabled experiences. DISCUSSION Later life disability is measured nonparametrically to distinguish patterns among long-term trajectories. Findings suggest that more recent cohorts are more likely to forego or delay disability over a decade rather than experience prolonged periods of mild to severe disablement. Serious health events such as stroke, along with diabetes, characterize trajectories of high impairment, warranting future research.
Generalization Performance of Regularized Ranking With Multiscale Kernels

The regularized kernel method for the ranking problem has attracted increasing attentions in machine learning. The previous regularized ranking algorithms are usually based on reproducing kernel Hilbert spaces with a single kernel. In this paper, we go beyond this framework by investigating the generalization performance of the regularized ranking with multiscale kernels. A novel ranking algorithm with multiscale kernels is proposed and its representer theorem is proved. We establish the upper bound of the generalization error in terms of the complexity of hypothesis spaces. It shows that the multiscale ranking algorithm can achieve satisfactory learning rates under mild conditions. Experiments demonstrate the effectiveness of the proposed method for drug discovery and recommendation tasks.
An Analysis of the Commonality and Type of Preintervention Assessment Procedures in the Journal of Organizational Behavior Management (2000–2015)

ABSTRACT We reviewed all issues of the Journal of Organizational Behavior Management (JOBM) from 2000 through 2015 to identify the percentage of empirical articles, which utilized some form of preintervention assessment. In addition, we categorized five types of assessment used and compared the number of assessments conducted in each category. Finally, because assessment is considered to be particularly important in the subdiscipline of behavioral safety (McSween, 2003), and prior research has not examined the commonality of assessment in this area, we also analyzed the frequency and type of assessment procedures used in behavioral safety and compared this to the use of assessment in OBM in general. Results indicated that 28% of the empirical articles in JOBM used some form of preintervention assessment. Indirect methods were the most often used type of assessment. In addition, 48% percent of the articles in JOBM, which employed a safety-related dependent variable, included some form of assessment. The most frequently used type of assessment in behavioral safety was historical assessment. Based on these data, the use of some form of preintervention assessment in OBM appears to be occurring with some regularity, and assessment in behavioral safety is more common relative to assessment in OBM in general.
Schwann cell‐like differentiation by adult oligodendrocyte precursor cells following engraftment into the demyelinated spinal cord is BMP‐dependent

The development of remyelinating strategies designed to enhance recruitment and differentiation of endogenous precursor cells available to a site of demyelination in the adult spinal cord will require a fundamental understanding of the potential for adult spinal cord precursor cells to remyelinate as well as an insight into epigenetic cues that regulate their mobilization and differentiation. The ability of embryonic and postnatal neural precursor cell transplants to remyelinate the adult central nervous system is well documented, while no transplantation studies to date have examined the remyelinating potential of adult spinal‐cord‐derived oligodendrocyte precursor cells (adult OPCs). In the present study, we demonstrate that, when transplanted subacutely into spinal ethidium bromide/X‐irradiated (EB‐X) lesions, adult OPCs display a limited capacity for oligodendrocyte remyelination. Interestingly, the glia‐free environment of EB lesions promotes engrafted adult OPCs to differentiate primarily into cells with immunophenotypic and ultrastructural characteristics of myelinating Schwann cells (SCs). Astrocytes modulate this potential, as evidenced by the demonstration that SC‐like differentiation is blocked when adult OPCs are co‐transplanted with astrocytes. We further show that inhibition of bone morphogenetic protein (BMP) signaling through noggin overexpression by engrafted adult OPCs is sufficient to block SC‐like differentiation within EB‐X lesions. Present data suggest that the macroglial‐free environment of acute EB lesions in the ventrolateral funiculus is inhibitory to adult spinal cord‐derived OPC differentiation into remyelinating oligodendrocytes, while the presence of BMPs and absence of noggin promotes SC‐like differentiation, thereby unmasking a surprising lineage fate for these cells. © 2006 Wiley‐Liss, Inc.
Prednisolone therapy in Duchenne muscular dystrophy prolongs ambulation and prevents scoliosis

Steroids may have a beneficial effect on the course of Duchenne muscular dystrophy (DMD). However, results vary in different studies. This study consisted of 66 DMD boys who were in the therapy group and 22 DMD boys in the control group. The mean ages were 6.8 ± 2.1 years (range 2.5–12.5) and 7.0 ± 1.3 years (range 5.0–9.0), respectively. We assessed muscle strength, 10‐m walking, ankle contracture, and loss of independent walking ability age and onset of scoliosis. Treatment regimen was oral prednisolone 0.75 mg/kg on alternate days, plus vitamin D 600–1200 units/day and a calcium‐enriched diet. After a follow‐up period of 2.75 ± 1.1 years (range 1.5–5) and when compared with controls, there was a statistically significant change in muscle strength between the two groups after 12 months (P < 0.05). Although 10‐m walking time decreased in therapy group (P < 0.05), there was not significance between the groups in the end. Boys in the control group developed significantly less ankle contractures (P < 0.05). None of the therapy group had scoliosis during the follow‐up period (mean age 10.8 ± 1.2 years), whereas seven boys of the control group had scoliosis at a mean age of 11.7 ± 2 years. Loss of walking ability age was statistically different between groups (P < 0.05). Our results indicate that, alternate‐day prednisolone regimen may prolong ambulation and scoliosis can be delayed or prevented.
Cell and Gene Therapy Approaches for Cardiac Vascularization

Despite encouraging preclinical results for therapeutic angiogenesis in ischemia, a suitable approach providing sustained, safe and efficacious vascular growth in the heart is still lacking. Vascular Endothelial Growth Factor (VEGF) is the master regulator of angiogenesis, but it also can easily induce aberrant and dysfunctional vascular growth if its expression is not tightly controlled. Control of the released level in the microenvironment around each cell in vivo and its distribution in tissue are critical to induce stable and functional vessels for therapeutic angiogenesis. The present review discusses the limitations and perspectives of VEGF gene therapy and of different cell-based approaches for the implementation of therapeutic angiogenesis in the treatment of cardiac ischemia.
Long-Term Treatment with n-3 Polyunsaturated Fatty Acids as a Monotherapy in Children with Nonalcoholic Fatty Liver Disease

Objective: To investigate the efficacy and safety of n-3 polyunsaturated fatty acids (PUFA) treatment in obese children with nonalcoholic fatty liver disease (NAFLD). Methods: One hundred and eight obese (body mass index (BMI) >95th percentile for age and sex) adolescents with NAFLD were included in the study. Mean age of the subjects was 13.8±3.9 years (9-17 yrs). The diagnosis of NAFLD was based on the presence of liver steatosis with high transaminases. The subjects were randomly divided into two groups. Group 1 (PUFA group, n=52) received a 1000 mg dose of PUFA once daily for 12 months and lifestyle intervention. Group 2 (placebo group, n=56) received a recommended diet plus placebo and lifestyle intervention for 12 months. Insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR) from fasting samples. Results: BMI, fasting insulin levels and HOMA-IR values in both groups decreased significantly at the end of the study. In group 1, 67.8% of the patients had a decrease from baseline in the prevalence of steatosis (p<0.001). Frequency of elevated alanine aminotransferase (ALT) levels (39.2% to 14.2%; p<0.01) and elevated aspartate aminotransferase (AST) levels (25% to 17.8%; p=0.01) decreased significantly in the PUFA group. Following a 12-month diet plus placebo and lifestyle intervention treatment, 40.3% (21) of the patients in the placebo group also showed a decrease in frequency of steatosis (p=0.04) and slight decreases in frequency of elevated ALT levels (38.4% to 28.8%; p=0.01) and AST levels (30.7% to 28.8%; p>0.05). Conclusion: Our results indicated that n-3 PUFA treatment is safe and efficacious in obese children with NAFLD and can improve ultrasonographic findings and the elevated transaminase levels.