Miracle-dz/UniFAR-FTUs huggingface dataset:
Disentangling the Effect of Top Management Support and Training on Systems Implementation Success: A Meta-Analysis

Systems implementation is an important topic, and numerous studies have been conducted to identify determinants of success. Among organizational factors that can have an impact on success, top management support and training are two of the most extensively studied variables. While the positive influence of both of these organizational factors is generally recognized, not all empirical evidence is supportive. Some researchers attribute the inconsistent findings to moderators such as task interdependence. Other researchers contend that the wide-ranging correlations observed in different studies are caused by nothing but statistical artifacts. Still another reason for the inconsistent results could be how the two variables are modeled. I meta-analyzed thirty prior studies that examine the effect of both top management support and training. The results support both independent variables having a moderate positive effect on implementation success. Additionally, they suggest that the most plausible model is one where training partially mediates the effect of top management support. Finally, the preponderance of evidence indicates that task interdependence does not moderate the effect of either top management support or training. Instead, the role of task interdependence is similar to that of top management support and training: as an independent variable with a direct effect on implementation success.
Are ACOs Ready to be Accountable for Medication Use?

BACKGROUND: Accountable care organizations (ACOs) have the potential to lower costs and improve quality through incentives and coordinated care. However, the design brings with it many new challenges. One such challenge is the optimal use of pharmaceuticals. Most ACOs have not yet focused on this integral facet of care, even though medications are a critical component to achieving the lower costs and improved quality that are anticipated with this new model. OBJECTIVES: To evaluate whether ACOs are prepared to maximize the value of medications for achieving quality benchmarks and cost offsets. METHODS: During the fall of 2012, an electronic readiness self-assessment was developed using a portion of the questions and question methodology from the National Survey of Accountable Care Organizations, along with original questions developed by the authors. The assessment was tested and subsequently revised based on feedback from pilot testing with 5 ACO representatives. The revised assessment was distributed via e-mail to a convenience sample (n=175) of ACO members of the American Medical Group Association, Brookings-Dartmouth ACO Learning Network, and Premier Healthcare Alliance. RESULTS: The self-assessment was completed by 46 ACO representatives (26% response rate). ACOs reported high readiness to manage medications in a few areas, such as transmitting prescriptions electronically (70%), being able to integrate medical and pharmacy data into a single database (54%), and having a formulary in place that encourages generic use when appropriate (50%). However, many areas have substantial room for improvement with few ACOs reporting high readiness. Some notable areas include being able to quantify the cost offsets and hence demonstrate the value of appropriate medication use (7%), notifying a physician when a prescription has been filled (9%), having protocols in place to avoid medication duplication and polypharmacy (17%), and having quality metrics in place for a broad diversity of conditions (22%). CONCLUSIONS: Developing the capabilities to support, monitor, and ensure appropriate medication use will be critical to achieve optimal patient outcomes and ACO success. The ACOs surveyed have embarked upon an important journey towards this goal, but critical gaps remain before they can become fully accountable. While many of these organizations have begun adopting health information technologies that allow them to maximize the value of medications for achieving quality outcomes and cost offsets, a significant lag was identified in their inability to use these technologies to their full capacities. In order to provide further guidance, the authors have begun documenting case studies for public release that would provide ACOs with examples of how certain medication issues have been addressed by ACOs or relevant organizations. The authors hope that these case studies will help ACOs optimize the value of pharmaceuticals and achieve the “triple aim” of improving care, health, and cost.
Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation

The aim of the present study was to compare aldehyde levels resulting from lipid peroxidation in exhaled breath condensate (EBC) and induced sputum (IS) supernatant of subjects with asthma and chronic obstructive pulmonary disease (COPD). Aldehydes (malondialdehyde (MDA), acrolein, n-hexanal (C6), n-heptanal (C7), n-nonanal (C9), 4-hydroxynonenal (HNE) and 4-hydroxyhexenal (HHE)) in both biological fluids were measured by liquid chromatography-tandem mass spectrometry. MDA concentrations in sputum were 132.5 nM (82.5–268.8) and 23.7 nM (9–53.7) in EBC. Similarly, C6, C7 and C9 concentrations in IS were 1.5–4.7-fold higher than in EBC. Acrolein levels were 131.1 nM (55.6–264.6) in IS and 45.3 nM (14.4–127.1) in EBC. The concentrations of HNE and HHE in IS were not significantly different from the levels in EBC. Aldehyde levels in EBC did not show any correlation with aldehyde levels in IS or with differential sputum cellular count. In COPD, MDA in EBC, but not its IS counterpart, was negatively correlated with the severity of disease. In conclusion, the data presented here show that aldehydes can be detected in both exhaled breath condensate and supernatant of induced sputum, but that their relative concentrations are different and not correlated with each other. Therefore, with regard to lipid peroxidation products, exhaled breath condensate and induced sputum must be considered as independent techniques.
Offset-Free One-Step Ahead State Predictor for Power Electronic Applications Using Robust Proportional–Integral Observer

This paper suggests an offset-free one-step ahead state predictor for power electronic applications such as power converters and motor drives in the presence of plant uncertainties. The proposed method is devised through the robust proportional-integral observer technique, considering the full state as the output, and it has the two advantages: 1) to adopt the integrator of the state estimation error for ensuring the offset-free state prediction performance and 2) to introduce the nonlinear damping term so that it suppresses the disturbances originated from a plant-model mismatch. Performing the realistic simulations based on the PowerSIM software, it is shown that the proposed method provides an efficient one-step ahead state prediction performance despite the plant uncertainties.
Discourse Analysis: Investigating Processes of Social Construction

Preface 1. What is Discourse Analysis? Defining Discourse Analysis Reasons for Using Discourse Analysis What Lies Ahead 2. The Variety of Discourse Analysis Theoretical Perspectives in Dscourse Analysis Empirical Studies in Discourse Analysis A Useful Methodology 3. Our Research Program Studying Identity Revitalizing Our Critical Approach A New Perspective on Exsisting Theoretical Debates Why We Use Discourse Analysis 4. The Challenges of Discourse Analysis Developing a Research Question Selecting a Site Collecting Data Analyzing the Data Writing Up the Study Make It Interesting 5. Conclusions Contributions Challenges On a Personal Note References About the Authors
Impact of ageing on presentation and outcome of mitral regurgitation due to flail leaflet: a multicentre international study.

AIMS Define the impact of age at diagnosis on degenerative mitral regurgitation (MR) prognosis. METHODS AND RESULTS The Mitral regurgitation International DAtabase (MIDA) is a multicentre registry of MR due to flail leaflets including 862 patients (65 ± 12 years) diagnosed by echocardiography. The 498 older patients (≥65 years at diagnosis) were compared with the 364 younger (<65) with regard to presentation and the outcome was compared with that expected in the general population. Older vs. younger patients had MR of similar severity and ventricular overload but presented with more MR consequences and incurred higher mortality [risk ratio (rr) 95% confidence interval (95% CI) 4.7 (2.5-10.0), P < 0.001] independently of co-morbidity. Compared with expected survival [relative risk (95% confidence interval)], excess mortality, non-significant in younger patients [1.1 (0.6-2.0), P = 0.65], was prominent in older patients [1.4 (1.2-1.7), P < 0.001]. Compared with expected, excess heart failure (HF) occurred in younger [9.3 (6.5-13.3), P < 0.0001) and in older patients [6.7 (5.6-8.1), P < 0.0001]. Excess atrial fibrillation (AF) was even higher in younger [6.9 (4.5-10.6), P < 0.0001] than in older patients [3.5 (2.6-4.7), P < 0.0001; P < 0.001 for comparison between age groups]. Subsequent excess mortality [rr (95% CI)] was associated with occurrence of HF and/or AF in both age groups [13.5 (7.4-24.6), P < 0.001]. Mitral surgery was associated with reduced long-term mortality in older patients and lower rate of HF in both the age groups (all P < 0.01). CONCLUSIONS Both older and younger patients incurred excess risk of complications. Older patients suffered excess mortality, AF, and HF, whereas younger incurred excess morbidity linked to subsequent long-term excess mortality. The excess risks of uncorrected degenerative MR should be considered in deliberating surgical management, which significantly reduced mortality in older patients and HF in younger patients.
The Effect of Communication Media on Cooperation

Abstract We examine how communication affects cooperation with the help of seven standard public goods experiments that only differ with respect to the medium of pre-play communication. Our treatments include bidirectional and unidirectional communication via (mostly electronic) auditory and/or visual channels. The results suggest that successful cooperation is attributable to the opportunity of ‘coordinating’ behavior in the communication phase. Furthermore, both the level and the stability of cooperation significantly interact with the communication medium, even though the content of communication is remarkably similar across the communication treatments.
A Single-Dose, Open-Label Study of the Pharmacokinetics, Safety, and Tolerability of Lisdexamfetamine Dimesylate in Individuals With Normal and Impaired Renal Function

Background: Lisdexamfetamine (LDX) and D-amphetamine pharmacokinetics were assessed in individuals with normal and impaired renal function after a single LDX dose; LDX and D-amphetamine dialyzability was also examined. Methods: Adults (N = 40; 8/group) were enrolled in 1 of 5 renal function groups [normal function, mild impairment, moderate impairment, severe impairment/end-stage renal disease (ESRD) not requiring hemodialysis, and ESRD requiring hemodialysis] as estimated by glomerular filtration rate (GFR). Participants with normal and mild to severe renal impairment received 30 mg LDX; blood samples were collected predose and serially for 96 hours. Participants with ESRD requiring hemodialysis received 30 mg LDX predialysis and postdialysis separated by a washout period of 7–14 days. Predialysis blood samples were collected predose, serially for 72 hours, and from the dialyzer during hemodialysis; postdialysis blood samples were collected predose and serially for 48 hours. Pharmacokinetic end points included maximum plasma concentration (Cmax) and area under the plasma concentration versus time curve from time 0 to infinity (AUC0–∞) or to last assessment (AUClast). Results: Mean LDX Cmax, AUClast, and AUC0–∞ in participants with mild to severe renal impairment did not differ from those with normal renal function; participants with ESRD had higher mean Cmax and AUClast than those with normal renal function. D-amphetamine exposure (AUClast and AUC0–∞) increased and Cmax decreased as renal impairment increased. Almost no LDX and little D-amphetamine were recovered in the dialyzate. Conclusions: There seems to be prolonged D-amphetamine exposure after 30 mg LDX as renal impairment increases. In individuals with severe renal impairment (GFR: 15 ⩽ 30 mL·min−1·1.73 m−2), the maximum LDX dose is 50 mg/d; in patients with ESRD (GFR: <15 mL·min−1·1.73 m−2), the maximum LDX dose is 30 mg/d. Neither LDX nor D-amphetamine is dialyzable.
Cross-Lingual Dependency Parsing with Universal Dependencies and Predicted PoS Labels

This paper presents cross-lingual models for dependency parsing using the first release of the universal dependencies data set. We systematically compare annotation projection with monolingual baseline models and study the effect of predicted PoS labels in evaluation. Our results reveal the strong impact of tagging accuracy especially with models trained on noisy projected data sets. This paper quantifies the differences that can be observed when replacing gold standard labels and our results should influence application developers that rely on crosslingual models that are not tested in realis-
Improvements in Clinical Practice for Fertility Preservation Among Young Cancer Patients: Results from Bundled Interventions.

AIMS The consequences of cancer and treatment on fertility can be a continuing source of distress for adolescents and young adults. The study aims were to assess the effects of bundled interventions on clinical practice concerning fertility in young people aged 14-25 years with cancer. METHODS Bundled interventions, including development of quality indicators, resources, and targeted education, were introduced during 2015 across five cancer centers. Data before interventions (2012-2014) were compared with data prospectively collected during 2015-2016. Relative risks (RR) with 95% confidence intervals (CI) were calculated to assess effects of interventions. RESULTS Compared with the pre-intervention cohort (n = 260), the post-intervention cohort (n = 216) was 1.47 times more likely to have documented discussion of risk of infertility (95% CI 1.12-1.63, p = <0.001). Similarly, documented referral to fertility specialists was more likely in the post-intervention cohort (RR 1.53, 95% CI 1.26-1.87, p = <0.001) as was documented fertility preservation outcomes (RR 2.56, 95% CI 1.91-3.44, p = <0.001). These differences were significant across age, gender, and diseases. Females had greater improvement in documented risk of infertility discussion between cohorts (RR 1.70, 95% CI 1.19-2.08, p = <0.001). Among diseases, the greatest improvements were seen in those with brain cancers (RR 2.15, 95% CI 1.28-3.62, p = 0.004) and soft tissue sarcoma (RR 2.60, 95% CI 1.17-5.78, p = 0.02). CONCLUSIONS We have demonstrated the effects of bundled interventions to improve clinical practice associated with fertility preservation in young people with cancer. Interventions were successful for reducing disparities identified in the pre-intervention cohort associated with gender and certain diseases. Assessment of the quality of patient care is not possible without accurate, consistent documentation.
Delay and power monitoring schemes for minimizing power consumption by means of supply and threshold voltage control in active and standby modes

This paper describes newly developed delay and power monitoring schemes for minimizing power consumption by means of the dynamic control of supply voltage V/sub DD/ and threshold voltage V/sub TH/ in active and standby modes. In the active mode, on the basis of delay monitoring results, either VDD control or VTH control is selected to avoid any oscillation problem between them. In V/sub DD/ control, on the basis of delay monitoring results, VDD is adjusted so as to be maintained at the minimum value at which the chip is able to operate for a given clock frequency. In V/sub TH/ control, on the basis of power monitoring results, VTH is adjusted so as to maintain a certain switching current I/sub SW//leakage current I/sub LEAK/ ratio known to indicate minimum power consumption. In the standby mode, the precision of power monitoring (which detects optimum body bias by comparing subthreshold current I/sub SUBTH/ to substrate current I/sub SUB/) is improved by taking into consideration both the effects of lowering V/sub DD/ and the effects of the presence of gate-oxide leakage current. Experimental results with a 90-nm CMOS device indicate that use of the proposed power monitoring results in the successful minimizing of power consumption. It does so by making it possible to: 1) maintain the I/sub SW//ILEAK ratio in the active mode and 2) detect optimum body bias conditions (I/sub SUBTH/=ISUB) within an error of less than 20% with respect to actual minimum leakage current values in the standby mode.
A framework for multi-robot pose graph SLAM

We introduce a software framework for real-time multi-robot collaborative SLAM. Rather than building a complete SLAM system, our framework is designed to enable collaborative mapping for existing (single-robot) SLAM systems in a convenient fashion. The framework aggregates local pose graphs obtained from its multiple robots into a global pose graph, which it then feeds back to the robots to increase their mapping and localization effectiveness. The framework can potentially work with various SLAM algorithms, as long as they provide a pose graph with an image associated with each node, and absolute scaling. The merging of pose graphs is purely visual-based and does not require well-defined initial robot positions nor environment markers. To handle network delays, we propose a graph correction scheme that avoids using mutexes (and thus avoids modifying the existing SLAM system) by assuming local graph consistency. Furthermore, we propose a simple image feature filtering method that uses an associated depth image to filter image features unsuitable for scene recognition. We demonstrate the framework's functionality with several interior datasets that we have collected using three robots.
Morphologic Differences of the Endocardial Electrogram in Beats of Sinus and Ventricular Origin *

The lack of accurate arrhythmia detection and identification is one of the major obstacles to improvement in the efficacy of antitachycardia devices. We evaluated a method for detection of beats of ventricular origin compared to sinus rhythm based on the morphology of the endocardial electrogram. In order to compare mechanically induced ventricular beats to normal sinus beats, endocardial electrograms from a standard pacing electrode were recorded from eight open‐chested dogs. Time and frequency domain features analyzed included peak‐to‐peak amplitude (AMP), maximal slew rate (dV/dT). and frequency content (‐3 dB downpoint). Quantitative morphologic comparison of the waveforms was performed using standard correlation and by the absolute area of difference between the waveform and a sinus beat template. The AMP and dV/dT for a group of ventricular beats did not differ significantly from beats of sinus origin. In the unipolar configurution ‐3 dB for ventricular beats was significantly different from sinus beats (p = .01), but overlap occurred in three of eight cases. Conversely, using either method of assessment of morphological differences, all ventricular beats could be identified without overlapping the values for normal beats. We concluded that morphologic analysis of the endocardial electrogram by such methods may be a highly accurate means of distinguishing between beats of sinus and ventricular origins. This technique may also be applicable to the problem of automatic rhythm identification by implanted devices.
Redistribution of Cellular and Herpes Simplex Virus Proteins from the Trans-Golgi Network to Cell Junctions without Enveloped Capsids

ABSTRACT Herpes simplex virus (HSV) and other alphaherpesviruses assemble enveloped virions in the trans-Golgi network (TGN) or endosomes. Enveloped particles are formed when capsids bud into TGN/endosomes and virus particles are subsequently ferried to the plasma membrane in TGN-derived vesicles. Little is known about the last stages of virus egress from the TGN/endosomes to cell surfaces except that the HSV directs transport of nascent virions to specific cell surface domains, i.e., epithelial cell junctions. Previously, we showed that HSV glycoprotein gE/gI accumulates extensively in the TGN at early times after infection and also when expressed without other viral proteins. At late times of infection, gE/gI and a cellular membrane protein, TGN46, were redistributed from the TGN to epithelial cell junctions. We show here that gE/gI and a second glycoprotein, gB, TGN46, and another cellular protein, carboxypeptidase D, all moved to cell junctions after infection with an HSV mutant unable to produce cytoplasmic capsids. This redistribution did not involve L particles. In contrast to TGN membrane proteins, several cellular proteins that normally adhere to the cytoplasmic face of TGN, Golgi, and endosomal membranes remained primarily dispersed throughout the cytoplasm. Therefore, cellular and viral membrane TGN proteins move to cell junctions at late times of HSV infection when the production of enveloped particles is blocked. This is consistent with the hypothesis that there are late HSV proteins that reorganize or redistribute TGN/endosomal compartments to promote virus egress and cell-to-cell spread.
The Haunted Self: Structural Dissociation and the Treatment of Chronic Traumatization

They typically have a wide array of symptoms, often classified under different combinations of comorbidity, which can make assessment and treatment complicated and confusing for the therapist. Many patients have substantial problems with daily living and relationships, including serious intrapsychic conflicts and maladaptive coping strategies. Their suffering essentially relates to a terrifying and painful past that haunts them. Even when survivors attempt to hide their distress beneath a facade of normality-a common strategy-therapists often feel besieged by their many symptoms and serious pain. Small wonder that many survivors of chronic traumatization have seen several therapists with little if any gains, and that quite a few have been labeled as untreatable or resistant. In this book, three leading researchers and clinicians share what they have learned from treating and studying chronically traumatized individuals across more than 65 years of collective experience. Based on the theory of structural dissociation of the personality in combination with a Janetian psychology of action, the authors have developed a model of phase-oriented treatment that focuses on the identification and treatment of structural dissociation and related maladaptive mental and behavioral actions. The foundation of this approach is to support patients in learning more effective mental and behavioral actions that will enable them to become more adaptive in life and to resolve their structural dissociation. This principle implies an overall therapeutic goal of raising the integrative capacity, in order to cope with the demands of daily life and deal with the haunting remnants of the past, with the "unfinished business" of traumatic memories. Of interest to clinicians, students of clinical psychology and psychiatry, as well as to researchers, all those interested in adult survivors of chronic child abuse and neglect will find helpful insights and tools that may make the treatment more effective and efficient, and more tolerable for the suffering patient.