Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of psychosocial factors on low back pain in industrial workers.

AIM To test the hypothesis that workplace psychosocial factors such as demand, control, support, job satisfaction and job appreciation can predict the future onset of disabling low back pain (LBP). METHODS The present study involved a prospective cohort of 4500 Iranian industrial workers. Data were gathered by means of a self-reported questionnaire about LBP, as well as working life exposure, lifestyle factors, social exposures, co-morbidity, life events and psychosomatic complaints in 2004. All new episodes of disabling LBP resulting in medically certified sick leave during the 1-year follow-up registered by occupational health clinic inside the factory. RESULTS The participation rate was good (85%). A total of 744 subjects reported current LBP (point prevalence cases). A total of 52 (<2%) new episodes of disabling LBP were observed during the 1-year follow-up (incident cases). Male employees reported higher demands, lower control and lower support than female employees. Employees with high demands, low control, job strain, low job satisfaction and low job appreciation showed increased odds ratios, and these results were statistically significant. CONCLUSIONS Few prospective studies in this field have been published, but all of them are related to industrialized countries. This prospective study suggests the aetiological role of job strain for LBP. The findings of this study indicate a substantial potential for disease prevention and health promotion at the workplace.
NADPH oxidase activation played a critical role in the oxidative stress process in stable coronary artery disease.

OBJECTIVES The study was designed to investigate the oxidative stress levels of endothelial progenitor cells (EPCs) in stable coronary artery disease (CAD) and to explore the underlying mechanisms of NADPH oxidase activation and subsequent EPCs dysfunction. METHODS EPCs were isolated from patients with stable CAD (n=50) and matched healthy volunteers (n=50). NADPH oxidase activation was detected by measuring the expression of each subunit using western blotting and qPCR analyses and the membrane translocation of p47phox using immunofluorescence. The in vivo angiogenesis capacity was evaluated using immunofluorescence by transplanting EPCs into a rat hind limb ischemia model. The PKC inhibitor GÖ-6983 was used to determine the role of PKC in NADPH oxidase activation. RESULTS Oxidative stress level was increased and the in vivo angiogenesis capacity was impaired in EPCs obtained from CAD subjects with the activation of NADPH oxidase. P47phox membrane translocation increased in CAD group vs controls. These effects were resolved by NADPH oxidase inhibition. Up-regulation of PKCα/β2 was found in EPCs from CAD subjects, PKC inhibition GÖ-6983 could reduce the expression and activity of NADPH oxidation. CONCLUSIONS NADPH oxidase activation via p47phox membrane translocation played a critical role in the initiation and progression of CAD, and the PKCα/β2 signaling pathway might be involved.
An Analysis of International Price Differentials on eBay

"Online auction sites like eBay provide ways to measure what consumers buy and how much they pay. Does this imply that consumers pay similar prices, irrespective of their location? Comparing prices for homogeneous, tradable goods in the euro area and the United Kingdom, we find that prices differ significantly. The differential is not related to countries' having different currencies. However, price dispersion-the variance of prices-does seem to be smaller if two countries share a common currency. Our results confirm the importance of national borders in explaining price differences and their magnitude is related to (not) sharing a common currency. " ("JEL" E30, E31, E50, F40) Copyright (c) 2009 Western Economic Association International.
Sepsis and Scientific Revolutions

Hypothesis:The therapeutic approach to sepsis is following an evolutionary process of scientific discovery as articulated in the landmark work by Kuhn, The Structure of Scientific Revolutions, first published 50 years ago. Background:Incremental advances, beginning with the introduction of antimicrobials and most recently highlighted by revised, evidence-based guidelines for the management of sepsis, have been accompanied by episodic paradigm shifts. Although some of these have shown success, there are numerous, noteworthy failures, largely involving immune- and coagulation-based therapeutic strategies. Conclusion:A sustained paradigm shift in the approach to treating sepsis has yet to emerge, but recent data suggest that an open-minded posture informed by novel pathobiologic findings may eventually bear fruit.
The type III effector HopF2 Pto targets Arabidopsis RIN4 protein to promote Pseudomonas syringae virulence

Plant immunity can be induced by two major classes of pathogen-associated molecules. Pathogen- or microbe-associated molecular patterns (PAMPs or MAMPs) are conserved molecular components of microbes that serve as “non-self” features to induce PAMP-triggered immunity (PTI). Pathogen effector proteins used to promote virulence can also be recognized as “non-self” features or induce a “modified-self” state that can induce effector-triggered immunity (ETI). The Arabidopsis protein RIN4 plays an important role in both branches of plant immunity. Three unrelated type III secretion effector (TTSE) proteins from the phytopathogen Pseudomonas syringae, AvrRpm1, AvrRpt2, and AvrB, target RIN4, resulting in ETI that effectively restricts pathogen growth. However, no pathogenic advantage has been demonstrated for RIN4 manipulation by these TTSEs. Here, we show that the TTSE HopF2 Pto also targets Arabidopsis RIN4. Transgenic plants conditionally expressing HopF2 Pto were compromised for AvrRpt2-induced RIN4 modification and associated ETI. HopF2 Pto interfered with AvrRpt2-induced RIN4 modification in vitro but not with AvrRpt2 activation, suggestive of RIN4 targeting by HopF2 Pto . In support of this hypothesis, HopF2 Pto interacted with RIN4 in vitro and in vivo. Unlike AvrRpm1, AvrRpt2, and AvrB, HopF2 Pto did not induce ETI and instead promoted P. syringae growth in Arabidopsis. This virulence activity was not observed in plants genetically lacking RIN4. These data provide evidence that RIN4 is a major virulence target of HopF2 Pto and that a pathogenic advantage can be conveyed by TTSEs that target RIN4.
Audits, Reputation, and Repeated Interaction in a Capital Budgeting Setting

This experimental study investigates the use of audits as a control instrument in capital budgeting processes and factors that contribute to audit efficiency (or inefficiency) in a repeated relationship. We disentangle reputational aspects of superiors and subordinates from an increased social content in repeated relationships. In settings where subjects face new counterparts every round, we find that reputational aspects strongly affect the superiors' and subordinates' behavior. This leads to a decrease in slack and an increase in the superior payoff. However, in a repeated relationship with an increased level of social content, these benefits are no longer present. In fact, the subordinates' ability to retaliate against their superior for prior punishments in the repeated setting by reporting more slack in later rounds has negative effects on the use of audits and decreases audit efficiency. These findings imply that, in repeated relationships, social factors play an important role and might impair the disciplining effects of audits.
Why Big Nations Lose Small Wars: The Politics of Asymmetric Conflict

The Vietnam and Algerian wars have demonstrated that the overwhelming conventional military superiority of major powers is no guarantee against their defeat in wars against small nations. For external powers such wars are necessarily “limited,” which constrains escalation above certain levels. With no direct survival interest at stake, fighting the war does not take automatic priority over the pursuit of other social, political, and economic objectives. Prosecuting the war consumes resources—economic, human, and political—which are thus not available for the pursuit of these other objectives. In the absence of a quick victory this creates the potential for those political divisions which historically have shifted the balance of forces in the metropolis in favor of withdrawal. For the insurgents, the fact of invasion and occupation generates cohesion, minimizes constraints on mobilization, and maximizes the willingness to incur costs. Precisely the opposite effects tend to characterize the war effort of the external power. A conceptual framework for the analysis of the evolution and outcome of such conflicts is presented and its applications and limitations discussed.
Intertester reliability of a low back pain classification system.

STUDY DESIGN This prospective study of intertester reliability examined pairs of therapists' ability to agree independently on a patient's low back pain diagnosis. OBJECTIVE To determine the intertester reliability of a low back pain classification system among experienced and novice clinicians. BACKGROUND Many of the disparate categorization schemes for patients with low back pain are purely nominal, assigning designations based on the presumptive source of the problem without providing any practical guide for rehabilitation. A useful classification scheme reliably groups patients into treatment-directing categories. METHODS The study included 204 patients with low back pain referred to 10 clinics across Canada. Paired physiotherapists performed separate physical examinations on each patient. Both examiners then completed a simple ballot choosing one of five pain patterns. RESULTS Agreement on patient classification by independent examiners was 78.9% (kappa = 0.61). CONCLUSION This clinically relevant and clearly defined pain pattern system uses key elements of the history and examination to classify patients with low back pain. The pattern provides a framework for initiating active rehabilitation strategy. Using this approach, clinicians agreed on the categorization of 78.9% of mechanical low back pain cases.
Variants of the MATP/SLC45A2 gene are protective for melanoma in the French population

In this study, we investigated whether variants in three key pigmentation genes—MC1R, MATP/SLC45A2, and OCA2—were involved in melanoma predisposition. A cohort comprising 1,019 melanoma patients (MelanCohort) and 1,466 Caucasian controls without skin cancers were studied. A total of 10 polymorphisms, including five functional MC1R alleles (p.Asp84Glu, p.Arg142His, p.Arg151Cys, p.Arg160Trp, and p.Asp294His), two nonsynonymous SLC45A2 variants (p.Phe374Leu and p.Glu272Lys), and three intronic OCA2 variants previously shown to be strongly associated with eye color (rs7495174 T>C, rs4778241 G>T, and rs4778138 T>C) were genotyped. As expected, MC1R variants were closely associated with melanoma risk (P value <2.20.10−16; odds ratio [OR]=2.29 [95% confidence interval, CI=1.85–2.82 and OR=3.3 [95% CI=2.00–5.45], for the presence of one or two variants, respectively). Interestingly, the SLC45A2 variant p.Phe374Leu was significantly and strongly protective for melanoma (P‐value=2.12.10−15; OR=0.35 [95% CI=0.26–0.46] and OR=0.32 [95% CI=0.24–0.43], considering the genotypes Phe/Leu and Leu/Leu, respectively). MC1R and SLC45A2 variants had additive effects on melanoma risk, and after adjusting for pigmentation characteristics, the risk was persistent, even though both genes had a strong impact on pigmentation. Future studies may show whether genetic information could provide a useful complement to physical examination in predicting melanoma risk. Hum Mutat 0,1–7, 2008. © 2008 Wiley‐Liss, Inc.
Embedded Options in Treasury Bond Futures Prices: New Evidence

The Treasury bond futures contract has known embedded options, namely the quality option that permits the short side to deliver the cheapest bond and the three timing options that permit the short side to deliver at the most favorable time. In this article, the authors use a two-factor Cox–Ingersoll–Ross term structure model calibrated to the Treasury yield curve to compute the futures price with the forward pricing methodology. Using weekly futures prices from January 1992 through December 2000, they discover a substantial difference between the risk-neutral expectation used in the literature and the forward expectation that requires a recursive algorithm. The authors find that the correctly estimated futures price with the quality option is 1% lower on average than the futures price estimated in the literature. They also estimate the end-of-month timing option to be 23 basis points on average. This indicates that the end-of-month timing option value has been overestimated in the literature because of a wrongly estimated quality option value.
Lower Partial Moments-Proxy of Downside Risk

CAPM with all its controversies is still valid, popular and most used asset pricing model in world. Three major perspectives run among the researchers. The first rejects CAPM completely and the rest two advocates changes but differently. A scrupulous analysis yields that investors care more for downside risk rather than variance. Overwhelming evidence especially in emerging markets is present world-wide. Stochastic Dominance is a powerful tool to measure downside risk. Lower Partial Moment is developed proxy for Stochastic Dominance. Lower Partial Moment working comes under scrutiny. In last, its algorithm and relation of lower partial moment to downside-beta is discussed.
Alfentanil plasma concentration v. effect relationships in cardiac surgical patients.

Effects of alfentanil, preceded by lorazepam, on suppression of haemodynamic and somatic responses to noxious stimuli was studied in patients undergoing CABG. Plasma concentration of alfentanil, somatic and haemodynamic responses were measured at loss of consciousness, tracheal intubation, sternotomy and during multiple application of electrocoagulation. Additional alfentanil was administered i.v. to control unwanted responses. Study 1 (six patients): lorazepam 0.08 mg kg-1 by mouth 1-2 h before operation, alfentanil priming infusion (60 micrograms kg-1 min-1 for 10 min) followed by maintenance infusion (4.5 micrograms kg-1 min-1). With mean plasma alfentanil 1178 (SEM 54) ng ml-1, two patients required supplementary alfentanil to suppress somatic motor responses; one patients required nitroglycerin to control an increase in arterial pressure which was unresponsive to additional alfentanil following sternotomy. Study 2 (13 patients): lorazepam 0.04 mg kg-1 by mouth as premedication; one of three maintenance infusion rates of alfentanil: 5.4 (n = 4), 6.6 (n = 5), or 7.8 (n = 4) micrograms kg-1 min-1, each preceded by a proportional priming infusion. With plasma alfentanil 2181 (62) ng ml-1, somatic motor responses requiring additional alfentanil occurred in nine patients; haemodynamic responses in four of seven patients tested could not be controlled by alfentanil. The highest plasma concentration of alfentanil to prevent response to a stimulus other than tracheal intubation was different between the two studies (P less than 0.05). We conclude that alfentanil alone is insufficient to suppress haemodynamic and somatic motor responses to noxious stimulation during CABG and that the role of premedication is significant.
Differences in prethrombin-1 activation with human or bovine factor Va can be attributed to the heavy chain

Summary Human and bovine factor Va (FVa) function similarly in the activation of prothrombin but differently in the activation of prethrombin-1 (Pre-1). Pre-1 activation with human FVa proceeds at about 22 percent of the rate with bovine FVa. The dependencies of initial rates on the FVa and Pre-1 concentrations indicate that the differential activity is expressed in kcat differences, rather than differences in the assembly of prothrombinase or the Km value of the substrate. The heavy and light chains of both species of FVa were separated and interspecies hybrids were constructed in the presence of Ca++. Studies of the activation of Pre-1 with these hybrids indicate that the species difference can be attributed specifically to the heavy chain of FVa. Analyses of the reactions by SDS-PAGE indicated that cleavage at Arg271 occurs at about the same rate with both species of FVa, but cleavage at Arg320 with human FVa is specifically retarded. A major difference in primary structure between the human and bovine FVa heavy chains comprises 10 residues at COOH-terminus, adjacent to the negatively charged hirudin-like DYDYQ sequence. These residues have pI values of 12.5 and 4.26 in human and bovine FVa, respectively. The lower value would complement the negatively charged DYDYQ sequence but the higher value would counteract it. Thus, we suggest that the differences in the COOH-terminus of the heavy chain are responsible for the differences in Pre-1 activation, and that it specifically influences cleavage at Arg320 in Pre-1.
Bayesian inferences on the recent island colonization history by the bird Zosterops lateralis lateralis

The founding of new populations by small numbers of colonists has been considered a potentially important mechanism promoting evolutionary change in island populations. Colonizing species, such as members of the avian species complex Zosterops lateralis, have been used to support this idea. A large amount of background information on recent colonization history is available for one Zosterops subspecies, Z. lateralis lateralis, providing the opportunity to reconstruct the population dynamics of its colonization sequence. We used a Bayesian approach to combine historical and demographic information available on Z. l. lateralis with genotypic data from six microsatellite loci, and a rejection algorithm to make simultaneous inferences on the demographic parameters describing the recent colonization history of this subspecies in four southwest Pacific islands. Demographic models assuming mutation–drift equilibrium or a large number of founders were better supported than models assuming founder events for three of four recently colonized island populations. Posterior distributions of demographic parameters supported (i) a large stable effective population size of several thousands individuals with point estimates around 4000–5000; (ii) a founder event of very low intensity with a large effective number of founders around 150–200 individuals for each island in three of four islands, suggesting the colonization of those islands by one flock of large size or several flocks of average size; and (iii) a founder event of higher intensity on Norfolk Island with an effective number of founders around 20 individuals, suggesting colonization by a single flock of moderate size. Our inferences on demographic parameters, especially those on the number of founders, were relatively insensitive to the precise choice of prior distributions for microsatellite mutation processes and demographic parameters, suggesting that our analysis provides a robust description of the recent colonization history of the subspecies.
Respiratory symptoms among Swedish swine producers.

Two hundred nine male farmers engaged in swine production, born in 1913 or later, and alive in 1985 received mailed questionnaires on respiratory symptoms, medical history, and exposure to contaminated air in swine confinement buildings. The response rate was 76%. The prevalence of three or more symptoms of bronchitis was higher than that in welders who had completed the same questionnaire--Mantel-Haenszel odds ratio 5.26 (1.9-14.8) for smoking subjects. The number of reported symptoms was strongly influenced by smoking habits (p less than .01) and by exposure (p less than .01), and by a positive interaction between these (p less than .01, two-way analysis of covariance). Air in swine confinement buildings is contaminated with bacterial endotoxins and organic dust, and it is concluded that it may pose a risk for airways diseases such as chronic bronchitis.
Confirmatory factor analysis of the Wechsler Memory Scale-III.

The latent structure of the Wechsler Memory Scale-III was analyzed by confirmatory factor analysis using the covariance matrix based on the 11 primary subtests from the standardization sample. Omnibus fit indexes and individual parameter estimates were examined. Of the five models evaluated, a three-factor model (working memory, auditory memory, and visual memory) provided the best fit for the standardization sample (NNFI = .98, RMSEA = .05, GFI = .98, BIC = 429.42). Models that proposed separate immediate and delayed memory constructs were hampered by inadmissible parameter estimates that signaled model specification errors. R2 values for the Faces subtests were uniformly low for all five models that suggested that this subtest has insufficient commonality with the visual memory construct.
Is the FST a Good Predictor of Extinction?

The organization of neutral genetic variation has long been used as a diagnostic tool to infer demographic properties of populations, and recently it has been shown that this information can also be used to estimate the magnitude of genetic deterioration in small or fragmented populations. A further step of this research is to assess whether neutral genetic indicators can serve to predict and compare the viabilities of endangered species. I use modeling to explore how ecological metapopulation settings are related to neutral genetic indicators (such as the fixation index [FST]), changes in genetic load, and metapopulation viability. The analysis indicates that genetic indicators are generally strongly and consistently correlated with the genetic load, population size and structure, and time of extinction but identifies two potential limitations for their use in viability assessments. First, the regime of environmental perturbations is not accurately reflected by neutral indicators, so that their predictive power may be reduced in variable environments. Second, many species are threatened by recent human‐induced changes of their habitat configuration. In most cases, genetic indicators may not have reached their equilibrium value in the altered habitat, which limits their ability to compare species with heterogeneous histories and life‐history traits.
Analyzing the effect of inventory policies on the nonstationary performance with transfer functions

In this paper we apply transfer function methods to analyze the performance of supply chains in response to nonstationary demand and, in particular, we investigate how various inventory policies and demand forecasting parameters affect supply chain responsiveness. In a single-echelon inventory system we investigate the performance of a common base stock policy. Specifically, we describe the order and inventory trajectories using discrete transfer functions, and we derive closed-form analytical expressions for the transient behavior in response to a step change in demand. We introduce performance measures commonly used to analyze nonstationary performance and derive closed-form expressions for these measures. Next, we study the performance of a two-echelon supply chain under installation stock and echelon stock policies. We explicate the performance tradeoff in response to stationary versus nonstationary demand, and show that the transient response of orders and inventory levels can be either underdamped or overdamped depending on the exponential smoothing parameter. We show that the echelon stock policy is more responsive than the installation stock policy when both policies have similar stationary performances.