Miracle-dz/UniFAR-FTUs huggingface dataset:
Matching methods for causal inference: Designing observational studies

Much research in the social sciences attempts to estimate the effect of some intervention or “treatment” such as a school dropout prevention program or television watching. However, particularly in the social sciences, it is generally not possible to randomly assign units to receive the treatment condition or the control condition, and thus the resulting data are observational, where we simply observe that some units received the treatment and others did not. In such cases, there is a need to control for differences in the covariate distributions between the treatment and control groups. Matching methods, such as propensity score matching, effect this control by selecting subsets of the treatment and control groups with similar covariate distributions. The overall theme is of replicating a randomized experiment in two ways: first, by comparing treated and control units who look as if they could have been randomly assigned to treatment or control status; and second, by forming the comparison groups without the use of the outcome, thus preventing intentional or unintentional bias in selecting a particular sample to achieve a desired result. This chapter focuses on how to design observational studies using matching methods and the related ideas of subclassification and weighting. We present practical guidance regarding the use of matching methods, as well as examples of their use and evidence of their improved performance relative to other methods of controlling for bias due to observed covariates.
A multicentre phase I and pharmacokinetic study of BN80915 (diflomotecan) administered daily as a 20-min intravenous infusion for 5 days every 3 weeks to patients with advanced solid tumours.

BACKGROUND BN80915 (diflomotecan) is an E-ring modified camptothecin analogue, which possesses greater lactone stability in plasma compared with other topoisomerase I inhibitors. This phase I study was carried out using a daily times five administration schedule (dx5) repeated three weekly. The primary objective was to determine the maximum tolerated dose (MTD) and recommended dose (RD) for phase II studies. Secondary objectives were to determine the safety and pharmacokinetic (PK) profile, and to make a preliminary assessment of antitumour activity. PATIENTS AND METHODS Diflomotecan was administered intravenously on days 1-5 every 3 weeks. Patients were treated in cohorts of three to six per dose level and the dose of diflomotecan was escalated according to modified Fibonacci schedule. Plasma concentrations of diflomotecan and its metabolite BN80942 were quantified. RESULTS Thirty patients were assessable for toxicity. Dose levels explored were 0.05, 0.1, 0.125 and 0.15 mg/m(2)/day. The 0.15-mg/m(2) dose level was determined to be the MTD. Toxicity was acceptable at the 0.125-mg/m(2)/day dose level. PK analysis showed the principal parameters were neither time nor dose dependent. There was a wide interpatient variability in PK at all dose levels. One patient with colorectal cancer, previously treated with irinotecan, had a partial response. A further eight patients had disease stabilisation. CONCLUSIONS The MTD and RD of diflomotecan administered according to a dx5 repeated three weekly are 0.15 and 0.125 mg/m(2)/day, respectively. In general, treatment was well tolerated; the principal toxicity was reversible myelosuppression. An objective response was seen in a patient previously treated with irinotecan.
Study of ambulatory blood pressure in diabetic children: prediction of early renal insult

Background Hypertension is a highly prevalent risk factor for cardiovascular disease in patients with type 1 diabetes mellitus. Elevated blood pressure (BP) promotes the development and progression of microvascular complications, eg, nephropathy and retinopathy. The purpose of this study was to identify and detect early BP changes in diabetic children and adolescents, aiming for the early prediction of future renal and cardiovascular disease risk during childhood. Methods and materials Ambulatory BP monitoring was undertaken for 40 normotensive type 1 diabetic children with mean age of 11.56±2.82 years, and 24 healthy children as control group with matched age and sex. Albumin/creatinine ratio and glycated hemoglobin were tested. BP indices and standard deviation scores were calculated using reference standards. The data were analyzed by SPSS software version 20 using mean and standard deviations for descriptive data. Correlation and regression analysis tests were used to study relations between BP indices and diabetic parameters. Results All parameters of BP z-scores were highly significantly increased in diabetic patients compared with controlled group (P<0.0001). The frequency of non-dipping was greater and highly significant in microalbuminuric diabetic patients (P<0.0001). Regression analysis revealed that BP parameters were significantly related to albumin/creatinine ratio, glycated hemoglobin, insulin dose, and body mass index. Conclusion Our observation revealed a clear link between the nocturnal BP and microalbuminuria which mandates BP follow-up via ambulatory BP monitoring with therapeutic intervention to prevent renal and cardiovascular diabetic complications in adulthood.
Chronic exercise preserves renal structure and hemodynamics in spontaneously hypertensive rats.

AIMS Exercise training (ExT) is a recommended adjunct to many pharmaceutical antihypertensive therapies. The effects of chronic ExT on the development of hypertension-induced renal injury remain unknown. We examined whether ExT would preserve renal hemodynamics and structure in the spontaneously hypertensive rat (SHR), and whether these effects were mediated by improved redox status and decreased inflammation. Normotensive WKY rats and SHR underwent moderate-intensity ExT for 16 weeks. One group of SHR animals was treated with hydralazine to investigate the pressure-dependent/independent effects of ExT. Acute renal clearance experiments were performed prior to sacrifice. Tissue free radical production rates were measured by electron paramagnetic resonance; gene and protein expression were measured by real time RT-PCR and Western blot or immunofluorescence, respectively. Plasma angiotensin II levels and kidney antioxidants were assessed. Training efficacy was assessed by citrate synthase activity assay in hind-limb muscle. RESULTS ExT delayed hypertension, prevented oxidative stress and inflammation, preserved antioxidant status, prevented an increase in circulating AngII levels, and preserved renal hemodynamics and structure in SHR. In addition, exercise-induced effects, at least, in part, were found to be pressure-independent. INNOVATION This study is the first to provide mechanistic evidence for the renoprotective benefits of ExT in a model of hypertension. Our results demonstrate that initiation of ExT in susceptible patients can delay the development of hypertension and provide renoprotection at the functional and ultrastructural level. CONCLUSION Chronic ExT preserves renal hemodynamics and structure in SHR; these effects are partially mediated by improved redox status and decreased inflammation.
Managing Trouble Responsibility and Relationships During Conversational Repair

Using conversation analysis, this article focuses on other-initiation of repair (e.g., What? , I'm sorry? ) of trouble speaking, hearing, and understanding. This article shows that the act of managing relationships is an essential feature of other-initiation of repair, and that different practices of repair-initiation can constitute different relational events that have different behavioral outcomes. Specifically, this article: (1) argues that context-free structures of interaction bias practices of repair such that other-initiated repair is vulnerable to communicating a stance that responsibility for trouble belongs to the speaker of the talk that inspired the repair-initiation; (2) discusses the implications of trouble responsibility for interpersonal disalignment and the organization of subsequent interaction; and (3) focuses on open-class (Drew, 1997) practices of repair initiation and argues that the apology-based format (I'm sorry? or Sorry? ) communicates a stance that trouble responsibility belongs to repair-initiators, rather than to their addressees.
The Role of Morphology in Diet and Flower Visitation by Five Species of Cuban Flower-Visiting Bats

Pollinator and flower morphology are important factors in structuring the plant-pollinator relationship. A pollinator’s morphology may influence aspects of its diet. Flower-visiting bats are important pollinators but very little is known about what influences their interactions with food plants. I examined the role of morphology in the partitioning of food resources for five species of flower-visiting Cuban bats. I analyzed cranial traits and body size to examine differences among species and to determine the degree of morphological specialization for flower-feeding for each species. I also collected dietary data from guano and used acoustic monitoring to assess bat activity at flowers. I found evidence of partitioning of plant resources among the bat species, although evidence of limiting resources was not observed. Morphological similarity between species did not predict dietary overlap. However, species differing in their morphological specialization for flower-feeding consumed resources and visited food plants at different frequencies.
Riding in cars with boys: Elinor Ostrom's adventures with the police

Abstract: More than 40 years ago, Elinor Ostrom began her adventures with the police. In order to combat the conventional view that ‘bigger means better’, Ostrom pioneered a fieldwork-based framework for measuring police services that utilized consumer surveys and thereby created a community-centered model of analysis for public services. In this paper, we contend that although Ostrom's career demonstrated the importance of employing multiple methods, her most enduring contributions and legacy came from on-the-ground research. Her case studies and fieldwork proved to be necessary for examining complex systems beyond the state–market dichotomy, and these methods of analysis should be defended as critical for inquiry into the variety of institutional arrangements.
Intra- and inter-species interactions within biofilms of important foodborne bacterial pathogens

A community-based sessile life style is the normal mode of growth and survival for many bacterial species. Under such conditions, cell-to-cell interactions are inevitable and ultimately lead to the establishment of dense, complex and highly structured biofilm populations encapsulated in a self-produced extracellular matrix and capable of coordinated and collective behavior. Remarkably, in food processing environments, a variety of different bacteria may attach to surfaces, survive, grow, and form biofilms. Salmonella enterica, Listeria monocytogenes, Escherichia coli, and Staphylococcus aureus are important bacterial pathogens commonly implicated in outbreaks of foodborne diseases, while all are known to be able to create biofilms on both abiotic and biotic surfaces. Particularly challenging is the attempt to understand the complexity of inter-bacterial interactions that can be encountered in such unwanted consortia, such as competitive and cooperative ones, together with their impact on the final outcome of these communities (e.g., maturation, physiology, antimicrobial resistance, virulence, dispersal). In this review, up-to-date data on both the intra- and inter-species interactions encountered in biofilms of these pathogens are presented. A better understanding of these interactions, both at molecular and biophysical levels, could lead to novel intervention strategies for controlling pathogenic biofilm formation in food processing environments and thus improve food safety.
Differences in Factors Predicting Outcome and Mortality after Mechanical Thrombectomy for Acute Large Vessel Stroke Between Patients over and Under 70 Years of Age: A Five Year Retrospective Study

Mechanical thrombectomy (MT) is an experimental interventional treatment for ischaemic stroke in the UK [1], which has been shown to offer increased rates of recanalisation in cases of large vessel occlusion compared to IV treatment alone or combined IV/IA thrombolysis [2]. Early randomised controlled trials failed to show benefit comparing MT to conventional treatment [3-6], but these trials were criticized for failing to optimise patient selection [7] and used older devices. Recently, four new large randomised controlled trials addressing these issues have proven significant benefit in functional outcome for MT over IV thrombolysis in selected patient groups [8-11].
Seismic Reflectivity in Carbon Dioxide Accumulations: A Review

It is widely recognized that the continuous increase in the concentration of carbon dioxide (CO2) in our atmosphere is a major cause of global climate change [1]. Consequently, in accordance with the objectives of the Kyoto Protocol, many carbon dioxide capture and storage projects are being developed worldwide to reduce and stabilize the emission of this greenhouse gas into the atmosphere. The geological storage of CO2 in many cases becomes a feasible option to accomplish this goal, giving rise to the science of carbon sequestration, a challenging task for governments, scientists and engineers [2].
Diversity of lactic acid bacteria isolated from AOC Salers cheese

The objective of this work was to describe the diversity of lactic acid bacteria in traditional raw milk Salers cheeses at the species and strain levels. The characterization of 381 strains isolated during ripening and various strain collections was investigated using physiological analysis and molecular techniques: Rep-PCR, species and genus specific amplifications and the sequence analysis of 16S rDNA for strain typing and taxonomic identification. The strains belonged to Lactobacillus plantarum, Lactobacillus paracasei, Lactococcus lactis, Lactococcus garviae, Enterococcus faecalis, Enterococcus faecium, Leuconostoc mesenteroides, Leuconostoc pseudomesenteroides, Streptococcus salivarius, Streptococcus millieri, Streptococcus macedonicus and Pediococcus pentosaceus. A wide phenotypic and genomic heterogeneity was observed within the different species (Lactobacillus plantarum, Lactobacillus paracasei and Leuconostoc mesenteroides) according to the origin and the time of ripening. The natural microflora was different from strain collection and each method must be combined to identify and characterize natural microflora. This study revealed the low selectivity of selective media used for the isolation of different groups of lactic acid bacteria except the Facultatively Heterofermentative lactobacilli medium selecting mesophile lactobacilli and SB medium selective for Enterococcus. The study reveals, for the first time, the microbial lactic acid bacteria community of Salers cheese and its diversity. A better knowledge of microbial flora will be useful to improve understanding of sensory quality of cheeses.
Knowledge Intensive Entrepreneurship in a Social Capital Perspective

In 1989 Mitton suggested that success for start-ups not only depends on who you are but also on whom you know. To study the importance of social capital and networks in relation to entrepreneurial activities, research in a Danish start-up context in two knowledge-intensive sectors has been carried out. The research methodology was based on a triangulation approach including a general questionnaire-based survey conducted through the Internet combined with a 85 in-depth interviews in purposefully sampled ventures. The analysis of the content and structure of social capital in relation to entrepreneurial networking activities in new technology-based small firms shows that teams are primarily composed of 'trusted alters', and that networking patterns and resource acquisition are highly influenced by entrepreneurs' attitude to and perception of networking.
A longitudinal study of environmental salmonella contamination in caged and free-range layer flocks

The environmental contamination by salmonella was examined over a 12-month period in 74 commercial layer flocks from eight farms in the UK, which previously had been identified as being contaminated with salmonella. Samples of faeces, dust, litter, egg belt spillage and wildlife vectors were taken, plus swabs of cages, feeders, drinkers, floors, egg belts and boots. Some sampling was performed in each month of the year. Numerous serovars were detected but Salmonella enterica serotype Enteritidis was the only persistent serotype found among single-age flocks. There was a significant correlation between qualitative environmental samples and semi-quantitative faeces samples. The level of environmental contamination increased significantly over time. There were significant temperature and seasonal effects upon contamination. Wildlife vectors proved to be sensitive samples for the detection of salmonella. The efficacy of cleaning and disinfection upon residual salmonella contamination, and upon subsequent flock contamination, was highly variable between and within premises. The variability between detected prevalences over time and between flocks indicates a need for regular, sensitive monitoring of flocks for salmonella to permit targeting of control measures aimed at eliminating contamination of the layer environment by salmonella. There is substantial scope for improvement of cleaning and disinfection procedures.
Corrosion Behavior of Cast Iron in Freely Aerated Stagnant Arabian Gulf Seawater

In this work, the results obtained from studying the corrosion of cast iron in freely aerated stagnant Arabian Gulf seawater (AGS) at room temperature were reported. The study was carried out using weight-loss (WL), cyclic potentiodynamic polarization (CPP), open-circuit potential (OCP), and electrochemical impedance spectroscopy (EIS) measurements and complemented by scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) investigations. WL experiments between two and 10 days’ immersion in the test electrolyte indicated that the weight-loss the cast iron increases with increasing the time of immersion. CPP measurements after 1 h and 24 h exposure period showed that the increase of time decreases the corrosion via decreasing the anodic and cathodic currents, as well as decreasing the corrosion current and corrosion rate and increasing the polarization resistance of the cast iron. EIS data confirmed the ones obtained by WL and CPP that the increase of immersion time decreases the corrosion of cast iron by increasing its polarization resistance.
Overall quality of outcomes framework scores lower in practices in deprived areas.

BACKGROUND There has been much debate as to whether quality points allocated through the new general medical services contract are more difficult to achieve for practices in deprived and rural areas. We used multiple regression to assess the relationships between deprivation, rurality and the number of overall quality points achieved by each practice. Multiple deprivation was significantly inversely related to quality points achieved. Practices in villages and towns gained 2% more quality points than urban areas and hamlets.
Most and Least Preferred Colours Differ According to Object Context: New Insights from an Unrestricted Colour Range

Humans like some colours and dislike others, but which particular colours and why remains to be understood. Empirical studies on colour preferences generally targeted most preferred colours, but rarely least preferred (disliked) colours. In addition, findings are often based on general colour preferences leaving open the question whether results generalise to specific objects. Here, 88 participants selected the colours they preferred most and least for three context conditions (general, interior walls, t-shirt) using a high-precision colour picker. Participants also indicated whether they associated their colour choice to a valenced object or concept. The chosen colours varied widely between individuals and contexts and so did the reasons for their choices. Consistent patterns also emerged, as most preferred colours in general were more chromatic, while for walls they were lighter and for t-shirts they were darker and less chromatic compared to least preferred colours. This meant that general colour preferences could not explain object specific colour preferences. Measures of the selection process further revealed that, compared to most preferred colours, least preferred colours were chosen more quickly and were less often linked to valenced objects or concepts. The high intra- and inter-individual variability in this and previous reports furthers our understanding that colour preferences are determined by subjective experiences and that most and least preferred colours are not processed equally.
Graphene-nanoplatelet-based photomechanical actuators

This paper reports large light-induced reversible and elastic responses of graphene nanoplatelet (GNP) polymer composites. Homogeneous mixtures of GNP/polydimethylsiloxane (PDMS) composites (0.1–5 wt%) were prepared and their infrared (IR) mechanical responses studied with increasing pre-strains. Using IR illumination, a photomechanically induced change in stress of four orders of magnitude as compared to pristine PDMS polymer was measured. The actuation responses of the graphene polymer composites depended on the applied pre-strains. At low levels of pre-strain (3–9%) the actuators showed reversible expansion while at high levels (15–40%) the actuators exhibited reversible contraction. The GNP/PDMS composites exhibited higher actuation stresses compared to other forms of nanostructured carbon/PDMS composites, including carbon nanotubes (CNTs), for the same fabrication method. An extraordinary optical-to-mechanical energy conversion factor (ηM) of 7–9 MPa W−1 for GNP-based polymer composite actuators is reported.
Integrating High School and the Community College

This article explores three incarnations of the idea to integrate high school and the community college—Leonard Koos’s 6-4-4 plan of public school organization, Middle College High School, and the early college high school initiative. The author discusses rationales for integrating high school and the first 2 years of college, as well as possible reasons why the 6-4-4 plan and middle college high schools were not as widely implemented as their founders may have envisioned. The article concludes with a look to the future and identifies policy changes that must occur if early colleges are to become a significant and successful pathway from high school both to and through college
The Cyclic Behavior of Translation Operators on Hilbert Spaces of Entire Functions

We show that the translation operator T : f(z) → f(z + 1), acting on certain Hilbert spaces consisting of entire functions of slow growth, is hypercyclic in the sense that for some function f in the space, the orbit {Tf}0 is dense. We further show that the operator T − I can be made compact, with approximation numbers decreasing as quickly as desired, simply by choosing the underlying Hilbert space to be sufficiently small. This shows that hypercyclic operators can arise as perturbations of the identity by “arbitrarily compact” operators. Our work extends that of G.D. Birkhoff (1929), who showed that T is hypercyclic on the Fréchet space of all entire functions, and it complements recent work of Herrero and Wang, who were the first to discover that perturbations of the identity by compacts could be hypercyclic.