Miracle-dz/UniFAR-FTUs huggingface dataset:
Characteristics of and outcomes for elderly patients with acute myocardial infarction: differences between females and males

Objectives This study analyzed age-adjusted sex differences among acute myocardial infarction (AMI) patients aged 75 years and above with regard to 7-year mortality (primary end point) and the frequency of angiograms and admission to the coronary care unit (CCU) as well as 1-year mortality (secondary end points). Methods A retrospective cohort study comprised 1,414 AMI patients (748 females and 666 males) aged at least 75 years, who were admitted to Sahlgrenska University Hospital in Gothenburg, Sweden, during two periods (2001/2002 and 2007). All comparisons between female and male patients were age adjusted. Results Females were older and their previous history included fewer AMIs, coronary artery bypass grafting procedures, and renal diseases, but more frequent incidence of hypertension. On the contrary, males had higher age-adjusted 7-year mortality in relation to females (hazard ratio [HR] 1.16 with corresponding 95% confidence interval [95% CI 1.03, 1.31], P=0.02). Admission to the CCU was more frequent among males than females (odds ratio [OR] 1.38 [95% CI 1.11, 1.72], P=0.004). There was a nonsignificant trend toward more coronary angiographies performed among males (OR 1.34 [95% CI 1.00, 1.79], P=0.05), as well as a nonsignificant trend toward higher 1-year mortality (HR 1.18 [95% CI 0.99, 1.39], P=0.06). Conclusion In an AMI population aged 75 years and above, males had higher age-adjusted 7-year mortality and higher rate of admission to the CCU than females. One-year mortality did not differ significantly between the sexes, nor did the frequency of performed coronary angiograms.
High-dose therapy and autologous stem cell transplantation in Korean patients with aggressive T/NK-cell lymphoma

The proportion of aggressive T/NK-cell lymphoma in Korea is larger than in the West, and it shows a lower response to conventional chemotherapy and poorer survival than diffuse large B-cell lymphoma. This study was undertaken to evaluate the response rate and survival and to document the prognostic factors in patients with T/NK-cell lymphoma who have undergone high-dose therapy (HDT). Eligibility for the study was a mature T/NK-cell lymphoma with initially poor risk (as high or high intermediate risk on age-adjusted International Prognostic Index) or relapsed cases. Twenty-eight patients from 6 centers were reviewed retrospectively. The M : F ratio was 20 : 8, and median age was 36 years (range 16 – 60 years). Twelve patients had unspecified peripheral T-cell lymphomas, 7 anaplastic large-cell lymphomas, 6 nasal T/NK-cell lymphomas, and 3 angioimmunoblastic T-cell lymphomas. Disease status at transplant were initially poor risk in 15, chemosensitive relapse in 8 and chemoresistant relapse in 5 patients, respectively. A complete reponse (CR) after HDT comprised 20 patients, including 16 with continued CR. Absolute neutrophil count ( > 500/μl) recovered at a median 11 days after autologous stem cell transplantation in 26 patients. Two therapy-related mortalites occurred. Estimated 3-year event-free survival and overall survival (OS) ( ± SE) were 24 ± 9 and 42 ± 10 months, respectively. Only CR status after HDT influenced OS (P = 0.000). Therefore, an initial approach with effective induction and HDT may result in a better outcome in T/NK-cell lymphoma.
Ultrastructural basis for interactions between central opioids and catecholamines. I. Rostral ventrolateral medulla

Opioids and some alpha 2-adrenergic agonists are both known for their potent hypotensive actions following local application to the rostral ventrolateral medulla (RVL), in particular the region containing the C1 adrenergic neurons. We sought to determine whether coexistence and/or synaptic interactions might account for the commonality of cardiovascular responses to opioids and catecholamines in the RVL. Dual light and electron microscopic (EM) immunoperoxidase labeling of a rat monoclonal antibody against the opioid peptide Leucine5 (Leu5)- enkephalin and immunoautoradiographic localization of a rabbit antiserum against the catecholamine synthesizing enzyme tyrosine hydroxylase (TH) were examined in single sections through the RVL of adult colchicine-pretreated rats. Cross-reactivity of the enkephalin antibody was most intense with Leu5-enkephalin. Methionine5-enkephalin as well as dynorphin A, but not beta-endorphin, were also recognized by the antisera. By light microscopy, the Leu5-enkephalin-like immunoreactivity (LE-LI) was identified by peroxidase reaction product in perikarya and processes. Most of the perikarya containing LE-LI were located dorsolaterally or ventromedially to those showing immunoautoradiographic labeling for TH. However, a few perikarya appeared to contain both LE-LI and TH-immunoreactivity (TH-I) which were difficult to differentiate by light microscopy. By EM, perikarya and dendrites immunoreactive for LE, TH, and both LE and TH were readily distinguishable. Perikarya and dendrites immunoautoradiographically labeled for TH alone were more numerous than those containing LE-LI or TH-I and LE-LI. Axon terminals also were immunolabeled either for one or both reaction products. However, the TH- labeled neurons constituted one of the primary (42% from a total of 118) targets of terminals containing LE-LI. Additionally, some of these terminals containing LE-LI shared a common target with TH-labeled terminals. These common target neurons contained either TH-I or TH-I and LE-LI. In most cases, the identified junctions were symmetric and the terminals with LE-LI (0.4–1.2 microns in diameter) contained either (1) a few small clear vesicles (scv's) and numerous intensely immunoreactive large (100–150 nm) dense-core vesicles (dcv's); or (2) many scv's and from 0–6 dcv's of a somewhat smaller (80–120 nm) diameter. The latter type of terminal was more consistently dually labeled for TH. The remaining terminals containing LE-LI formed synaptic junctions with unlabeled perikarya or dendrites (32%), were in apposition to other unlabeled as well as TH or LE- and TH-containing terminals (4%) or were without recognizable specializations within the plane of section (22%). (ABSTRACT TRUNCATED AT 400 WORDS)
An update on the IEM surface backscattering model

The integral equation approach to modeling scattering from rough surfaces was introduced in 1992. At that time, it was noted that there was a need to find a transition reflection coefficient that could change its argument from the incident angle to the specular angle as frequency or roughness scale got large. One such reflection coefficient was published in 2001. In this letter, we would like to include this reflection coefficient in the integral equation model to interpret several multifrequency backscattering measurements from surfaces with surface parameters defined by the investigators who acquired the data.
Self-Enforcing Stochastic Monitoring and the Separation of Debt and Equity Claims

This paper studies the incentive issues associated with self-enforcing stochastic monitoring in a model of investment and production. The efficient contract features a debt-like payment with a threshold in terms of the reported output in which all of the reported output is taken up to the threshold if monitoring doesn't occur and all of the output is taken if monitoring does occur. An output report above the threshold leads to zero probability of monitoring and just the threshold amount being paid out. The efficiency gap between the self-enforcing contract and the commitment constraint is minimized when the monitors hold no part of the residual claim on the firm, which we associate with equity. Misreporting by the manager is an important component of the efficient contract.
Under Consideration for Publication in Theory and Practice of Logic Programming Reasoning and Planning with Sensing Actions, Incomplete Information, and Static Causal Laws Using Answer Set Programming

We extend the 0-approximation of sensing actions and incomplete information in (Son and Baral 2001) to action theories with static causal laws and prove its soundness with respect to the possible world semantics. We also show that the conditional planning problem with respect to this approximation is NP-complete. We then present an answer set programming based conditional planner, called ASCP, that is capable of generating both conformant plans and conditional plans in the presence of sensing actions, incomplete information about the initial state, and static causal laws. We prove the correctness of our implementation and argue that our planner is sound and complete with respect to the proposed approximation. Finally, we present experimental results comparing ASCP to other planners.
Tolerance of droplet-digital PCR vs real-time quantitative PCR to inhibitory substances.

To the Editor: Real-time quantitative PCR (qPCR)1 is a rapid and sensitive method that forms the foundation for many clinical diagnostic tests. Droplet digital PCR (ddPCR) shares these qualities with qPCR, but owing to reaction partitioning, ddPCR is proposed to exhibit increased tolerance to interfering substances, making it an attractive alternative to qPCR for diagnostic applications (1, 2). The data to support this phenomenon and its mechanism, however, are currently lacking in the literature (3). Herein, we describe a series of experiments to compare the inhibition tolerance of laboratory-developed CMV qPCR and ddPCR (Bio-Rad Laboratories, QX-100) assays by introducing a panel of clinically relevant inhibitors (SDS, EDTA, and heparin) directly into the PCR reactions (4). Differences in the resulting inhibition curves and the half-maximal inhibitory concentrations (IC50) were then assessed. The laboratory-developed CMV qPCR is a double primer/probe Taqman assay that amplifies and detects the genes UL123 (IE)2 (enhances activation by IE2; interacts with basal transcriptional machinery and cellular transcription factor; disrupts ND10; involved in gene regulation [Human herpesvirus 5]) and UL55 (gB) (type 1 membrane protein; possible membrane fusogen; binds cell surface heparan sulphate; involved in cell entry; involved in cell-to-cell spread [Human herpesvirus 5]) with primers and probes previously described (5). The ddPCR assay uses the same primers and probes, with the dyes HEX replacing 6-FAM on the gB probe and BHQ-1 replacing TAMRA on both probes (Sigma-Aldrich). SDS, EDTA, and …
Massive black hole remnants of the first stars - III. Observational signatures from the past

The first stars forming in minihaloes at redshifts z > 20 may have been very massive and could have left behind massive black hole (MBH) remnants. In previous papers we investigated the hierarchical merging of these 'seed' MBHs and their associated haloes, using a semi-analytical approach consisting of a hierarchical merger tree algorithm and explicit prescriptions for the dynamics of merged substructure inside a larger host halo following a merger. We also estimated accretion luminosities for these MBHs and found them to be consistent with observations of ultraluminous X-ray point sources. Here we compute the strength of gravitational wave events as MBHs merge to form the more massive black holes that we predict reside in galaxy haloes today. If MBHs merge efficiently, we predict that as many as 10 4 -10 5 events per year may fall within the sensitivity limits of the proposed Laser Interferometer Space Antenna gravitational wave observatory. The collapse of the first massive stars to form MBHs may also be accompanied by gamma-ray bursts (GRBs). If this is the case and if GRBs are observable out to the redshifts of first star formation, we predict that about 10 5 -10 6 GRBs per year could be detected. As merging MBH binaries reach their last stable orbits before final coalescence, a fraction of the gravitational wave energy may be released as a pulse of gamma-rays (for instance, through interaction with material enveloping a merging MBH binary). This fraction has to be larger than about 10 -2 for MBH mergers to account for some beamed GRBs, and greater than 10 -6 for the gamma-rays to be detectable out to cosmological distances with upcoming GRB detector missions.
Lack of age-related increase in carotid artery wall viscosity in cardiorespiratory fit men

Objectives: Age-related arterial stiffening and reduction of arterial elasticity are attenuated in individuals with high levels of cardiorespiratory fitness. Viscosity is another mechanical characteristic of the arterial wall; however, the effects of age and cardiorespiratory fitness have not been determined. We examined the associations among age, cardiorespiratory fitness and carotid arterial wall viscosity. Methods: A total of 111 healthy men, aged 25–39 years (young) and 40–64 years (middle-aged), were divided into either cardiorespiratory fit or unfit groups on the basis of peak oxygen uptake. The common carotid artery was measured noninvasively by tonometry and automatic tracking of B-mode images to obtain instantaneous pressure and diameter hysteresis loops, and we calculated the effective compliance, isobaric compliance and viscosity index. Results: In the middle-aged men, the viscosity index was larger in the unfit group than in the fit group (2533 vs. 2018 mmHg·s/mm, respectively: P < 0.05), but this was not the case in the young men. In addition, effective and isobaric compliance were increased, and viscosity index was increased with advancing age, but these parameters were unaffected by cardiorespiratory fitness level. Conclusion: These results suggest that the wall viscosity in the central artery is increased with advancing age and that the age-associated increase in wall viscosity may be attenuated in cardiorespiratory fit men.
Nondestructive Evaluation of the Dynamic Elastic Moduli of Porous Iron Compacts

The effect of cold compaction and sintering of spherical iron powder on the dynamic elastic moduli of the partially densified material was studied. It was found that the elastic moduli of porous iron depend not only on density but also on the processing route that is followed. It was argued and demonstrated that the longitudinal sound velocity is more appropriate than density, as a parameter for quantitative nondestructive evaluation of the elastic moduli of porous iron. A general form of the dependence between the normalized elastic modulus M* and the normalized longitudinal sound wave velocity VL* was put forward: M* ≅(αVL*3 + βVL*2) C (v), where α and β are constants and C (v) is a function of the Poisson's ratio. This dependence was verified for the normalized bulk and shear moduli of porous iron compacts with data points from the literature.
Morbidity associated with failed vaginal birth after cesarean section

We investigated morbidity and factors associated with failed vaginal birth after cesarean delivery (VBAC). In a retrospective cohort study maternal and neonatal outcomes of women who underwent VBAC in three Nigerian University Teaching Hospitals were reviewed. Univariate, followed by multivariate analyses, were conducted. VBAC was successful in 683 of 1,013 women (67.4%), whereas 330 (32.6%) had failed VBAC. Failed VBAC was associated with higher incidence of chorioamnionitis, postpartum hemorrhage, blood transfusion, uterine rupture, hysterectomy, and composite major neonatal morbidities. Younger age, lack of previous vaginal delivery, induction of labor and fetal weight >4,000 g were risk factors for failed VBAC. A majority of women who try VBAC achieve a vaginal delivery. Failed VBAC is associated with increased maternal and neonatal morbidity and is somewhat predictable.
A trauma‐like elevation of plasma cytokines in humans in response to treadmill running

1 Elevated levels of cytokines, especially interleukin (IL)‐6 and IL‐1ra, can be measured in the plasma of athletes after exhaustive long term exercise. 2 The present study investigates the kinetics of several cytokines and chemokines in ten male athletes before, during and after 2.5 h of treadmill running at 75% of maximal oxygen consumption (VO2,max). Blood was sampled before, every half‐hour during running and every hour in the following 6 h recovery period. 3 The plasma concentration of IL‐6 increased after 30 min of running, and peaked at the end of running with a 25‐fold increase compared with the pre‐exercise value. IL‐1ra increased only after running, and peaked after 2 h of rest with an 18‐fold increase compared with the pre‐exercise value. No changes were found in the concentrations of IL‐1β, tumour necrosis factor (TNF)α, IL‐15 and macrophage inflammatory protein (MIP)‐1β, and the concentrations of IL‐8 and MIP‐1α were below detection limits. 4 The results suggest that very early events in exercise trigger the release of IL‐6, and that the cytokine response to exercise has similarities to that observed after trauma.
Phylogeny and taxonomy of Macrolepiota (Agaricaceae)

The position and composition of Macrolepiota within the Agaricaceae and its phylogenetic relationships with other members of the family were investigated, using both molecular (ITS and LSU rDNA sequences) and morphological characters. The molecular data separate the genus into two clades. The first clade comprises M. procera, M. mastoidea, M. clelandii and allies and is a sister group of Leucoagaricus and Leucocoprinus. The second, more diverse, clade, with M. rachodes and allies, M. globosa, Chlorophyllum molybdites, Leucoagaricus hortensis and Endoptychum agaricoides, is a sister group of Agaricus. The separation of the two clades is supported by morphological characters, such as the structure of the pileus covering, the stipitipellis and the shape of the germ pore and the spore apex. The two clades are regarded as genera for which the names Macrolepiota and Chlorophyllum are proposed. Macrolepiota nympharum does not belong to either clade but is assigned to the genus Leucoagaricus, close to L. leucothites. Endoptychum depressum is transferred to the genus Agaricus as A. inapertus.
Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration.

AIMS Transgenic mice are frequently used to investigate the role of genes involved in cardiac conduction. The QRS duration calculated from the electrocardiogram (ECG) is a commonly used measure for ventricular conduction time. However, the relation between ventricular activation and QRS duration calculated from a mouse surface ECG is not well understood. We aim to relate ventricular activation and repolarization patterns with the mouse ECG. METHODS AND RESULTS Ventricular activation and repolarization patterns generated by high-density optical mapping and a six-lead pseudo-ECG were compared in isolated mouse hearts. In addition, mouse ECGs were simulated in silico. Right-ventricular activation ends later than left-ventricular activation. Final activation coincided with the end of the QRS complex in leads III and aVF, but not in leads I, II, aVR, and aVL. The pattern of early repolarization (at 20% of repolarization, RT20) but not of RT50 or RT80 followed the activation pattern. After sodium channel blockade by ajmaline, total ventricular activation time increased by 10.0 ms, whereas QRS duration increased by only 2.1 ms. In mice carrying a mutation in Scn5a (1798insD), ventricular activation ended after the end of the QRS complex (12.9 ± 0.1 vs. 10.8 ± 0.3). CONCLUSION In the mouse, ventricular myocardium activation and early repolarization waves are simultaneously present. This hampers unequivocal interpretation of the duration of the QRS complex as a measure of ventricular activation duration, especially when conduction is slowed. Under these conditions mapping of local activation and repolarization patterns is required for correct interpretation of the ECG.
How many results per page?: A Study of SERP Size, Search Behavior and User Experience

The provision of "ten blue links" has emerged as the standard for the design of search engine result pages (SERPs). While numerous aspects of SERPs have been examined, little attention has been paid to the number of results displayed per page. This paper investigates the relationships among the number of results shown on a SERP, search behavior and user experience. We performed a laboratory experiment with 36 subjects, who were randomly assigned to use one of three search interfaces that varied according to the number of results per SERP (three, six or ten). We found subjects' click distributions differed significantly depending on SERP size. We also found those who interacted with three results per page viewed significantly more SERPs per query; interestingly, the number of SERPs they viewed per query corresponded to about 10 search results. Subjects who interacted with ten results per page viewed and saved significantly more documents. They also reported the greatest difficulty finding relevant documents, rated their skills the lowest and reported greater workload, even though these differences were not significant. This work shows that behavior changes with SERP size, such that more time is spent focused on earlier results when SERP size decreases.
DNA Methylation as Surrogate Marker For Gastric Cancer

Stomach cancer remains, stubbornly, highly prevalent in East Asia. Still, stomach cancer has few biomarkers by which it can be predicted. Helicobacter pylori infection, a known carcinogen of stomach cancer, usually goes undetected prior to cancer diagnosis, due to the poor mucosal environments that its related gastric atrophy causes. We propose, herein, an endoscopic-biopsy-based cancer-predicting DNA methylation marker. We semi-quantitatively examined the methylation-variable sites near the CpG-island margins by radioisotope-labeling methylation-specific polymerase chain reaction in association with H. pylori, which increases age-related over-methylation in CpG islands of gastric mucosa. These age-related methylation patterns of the transitional-CpG sites are proposed as useful surrogate markers for stomach cancer. It would be helpful for setting the optimal screening interval for high-risk subjects as well as for estimating the prognosis and the predictability for recurrence of early gastric cancer in patients having undergone endoscopic submucosal dissection. New screening-interval guidelines for gastric cancer should be suggested considering individual risk based on age, severity of atrophy, H. pylori status, and DNA methylation pattern.