Miracle-dz/UniFAR-FTUs huggingface dataset:
Dedicated to Dr. Guido Fanconi on the occasion of his 80th birthday Catch-up Growth in Malnutrition, Studied in Celiac Disease After Institution of Gluten-free Diet

Extract: Celiac disease provides a model for investigation of one form of infantile malnutrition occurring under fully controlled circumstances. Thirteen patients aged 9–15 months were followed for a period of at least 3 years while they were on a strict gluten-free diet.Observed values for height, weight, bone age, metacarpal diameter, and cortical thickness are compared with the normal range based on local standards, and the results are expressed as standard scores. The mean curves of these data are presented in Figures 1 and 2. At the time of diagnosis and the beginning of diet (zero time), all variables were retarded, and standard scores were significantly below normal in height (P < 0.01), weight (P < 0.001), bone age (P < 0.01), metacarpal cortex (P < 0.05), and diameter (P < 0.001). Weight was significantly more depressed than height (P < 0.01), bone age (P < 0.001), metacarpal cortex (P < 0.001), and diameter (P < 0.001). Height was significantly more depressed than bone age (P < 0.05). As the patients recovered, weight caught up faster than the other measurements; weight was not significantly below normal after the patients had been on a gluten-free diet for 6 months and it reached normal values between 6 months and 1 year after initiation of diet. Height and bone age did not reach normal levels until after 2 years of treatment, although the values were no longer significantly depressed after 1 year on the diet. Cortical thickness was no longer significantly depressed after 6 months on the diet; it reached normal values by 6 months to 1 year after initiation of diet, and then showed an overshooting type of catch-up with values remaining significantly elevated at 2 years (P < 0.05) and 3 years (P < 0.05) after the onset of diet. Metacarpal diameter showed a slow steady catch-up growth which remained below normal throughout the follow-up period although the values were no longer significantly below normal 3 years after patients had begun diet.The study provides evidence that children aged 1 year (±3 months) who suffer from malnutrition caused by celiac disease catch up completely in weight, height, bone age, and metacarpal cortical thickness during a dietary treatment period of 3 years.Speculation: Poor physical growth resulting from this type and this degree of malnutrition in the second half of the 1st year of life is completely remediable. Permanent somatic sequelae from a similar severity of late infantile malnutrition in underdeveloped countries, therefore, might not be inevitable, provided that the therapeutic program is optimal and adverse factors do not continue to operate.
The role of overt activity in children's imagery production.

WOLFF, PETER, and LEVIN, JOEL R. The Role of Overt Activity in Children's Imagery Production. CHILD DEVELOPMENT, 1972, 43, 537-547. The role of motor activity in children's formation of dynamic mental imagery was investigated in 2 experiments using a paired-associate recognition task. From the recognition data it was inferred that (a) the child's ability to form dynamic images relating 2 objects undergoes its most rapid development between the ages of 5 and 8; and (b) the preimagery child can generate dynamic mental imagery in which 2 objects interact if he concurrently engages in overt manipulation of the objects. This was true even when the child had no visual access to his movements or to the objects being manipulated. These results offer strong support for Piaget's theoretical ideas concerning the role of overt and covert activity in the production of mental imagery.
ErbB-β-Catenin Complexes Are Associated with Human Infiltrating Ductal Breast and Murine Mammary Tumor Virus (MMTV)-Wnt-1 and MMTV-c-Neu Transgenic Carcinomas*

Simultaneous deregulation of both Wnt and ErbB growth factors has previously been shown to result in the cooperative induction of mammary gland tumors. Using the murine mammary tumor virus (MMTV)-Wnt-1 transgenic model of mammary carcinoma, we have identified an unvarying association between β-catenin and epidermal growth factor receptor/c-Neu (ErbB1/ErbB2) heterodimers in mammary gland tumors, indicating a requirement for ErbB signaling in Wnt-mediated tumorigenesis. Expansion of these observations to a second transgenic model, MMTV-c-Neu, demonstrated similar tumor-specific interactions, including an ErbB1 ligand-inducible phosphorylation of both β-catenin and c-Neu. Direct relevance of these findings to human breast cancer was established upon examination of a set of human infiltrating ductal breast adenocarcinoma and lymph node metastasis tissues taken at surgery. These data revealed increased levels of β-catenin in tumors and metastases versus normal breast as well as an association between β-catenin and c-Neu that measurably occurs only in neoplasia, most strongly in metastatic lesions. These studies have identified a seemingly indispensable interaction between β-catenin and epidermal growth factor receptor/c-Neu heterodimers in Wnt-1-mediated breast tumorigenesis that may indicate a fundamental signaling event in human metastatic progression.
The Effect of Various Factors on Variability of Retinal Nerve Fiber Layer Thickness Measurements Using Optical Coherence Tomography

Purpose To evaluate the effects of various factors on the variability of retinal nerve fiber layer (RNFL) thickness measurements using the Stratus optical coherence tomography (OCT) in normal and glaucomatous eyes. Methods Four hundred seventy-four subjects (103 normal eyes and 371 glaucomatous eyes) were scanned to determine the RNFL thickness measurements using the Stratus OCT. Measurements were obtained twice during the same day. The standard deviation (SD) was used to compare the variability in RNFL thickness measurements of the normal subjects to that of the glaucomatous patients. Multivariate regression analysis was used to evaluate which covariates were independent predictors of SD in overall mean RNFL thickness. Results The mean SD of all RNFL thickness measurements was larger in the glaucoma group except in one sector. In the multivariate regression analysis, the average signal strength (SS) and the relative SS change (difference in SS between initial and repeat scans, divided by initial SS) were independent predictors of the SD in the RNFL thickness measurements (partial R2 = 0.018, 0.013; p = 0.016, 0.040, respectively). Conclusions Glaucomatous eyes tend to be more variable than normal eyes in RNFL thickness measurement using the Straus OCT. The average SS and the relative SS changes appear to correlate with the variability in RNFL thickness measurement. Therefore, the results of the RNFL analysis should not be interpreted independently of these factors.
Capacity and Delay Tradeoffs of MotionCast with Base Stations

In this paper, we study the multicast capacity-delay tradeoff of a wireless network consisting of mobile wireless nodes and base stations. $m = n^b$ base stations are regularly placed in a square region and $n$ is the number of mobile nodes in the network. We assume that mobile nodes move according to an independent and identical distributed (i.i.d.) pattern and each desires to send packets to $k = n^d$ distinctive destinations. Under this basic network model, we study capacity, delay tradeoff in two transmission protocols: 2-hop relay algorithm with and without redundancy. We derive that the upper bound of per-node capacity of 2-hop relay algorithm without redundancy is $O(n^{- \min\{1, 1 - b + d\}})$ and its corresponding delay is $\Theta(n^{\min\{1, 1 - b + d\}})$. The lower bound of delay of this protocol is $\Theta(n^{1-b})$, with a smaller capacity $O(n^{b-2})$. For 2-hop relay algorithm with redundancy, the largest capacity and its corresponding delay are $O(n^{-\min\{1, 1 - b + d\}})$ and $\Theta(n^{\frac{\min\{1, 1 - b + d\}} {2}})$. The smallest delay and its corresponding capacity are $\Theta(n^{\frac{1 - b}{2}})$ and $O(n^{\frac{b - 3}{2}})$. When $d > \frac{1}{2}$ or $b > \min\{\frac{1+d}{3}, 1 - d\}$, adding base stations will improve the tradeoff mentioned in \cite{WHWZH}.
Memory-Based Morphological Analysis

We present a general architecture for efficient and deterministic morphological analysis based on memory-based learning, and apply it to morphological analysis of Dutch. The system makes direct mappings from letters in context to rich categories that encode morphological boundaries, syntactic class labels, and spelling changes. Both precision and recall of labeled morphemes are over 84% on held-out dictionary test words and estimated to be over 93% in free text.
Accelerating Cardiac Bidomain Simulations Using Graphics Processing Units

Anatomically realistic and biophysically detailed multiscale computer models of the heart are playing an increasingly important role in advancing our understanding of integrated cardiac function in health and disease. Such detailed simulations, however, are computationally vastly demanding, which is a limiting factor for a wider adoption of in-silico modeling. While current trends in high-performance computing (HPC) hardware promise to alleviate this problem, exploiting the potential of such architectures remains challenging since strongly scalable algorithms are necessitated to reduce execution times. Alternatively, acceleration technologies such as graphics processing units (GPUs) are being considered. While the potential of GPUs has been demonstrated in various applications, benefits in the context of bidomain simulations where large sparse linear systems have to be solved in parallel with advanced numerical techniques are less clear. In this study, the feasibility of multi-GPU bidomain simulations is demonstrated by running strong scalability benchmarks using a state-of-the-art model of rabbit ventricles. The model is spatially discretized using the finite element methods (FEM) on fully unstructured grids. The GPU code is directly derived from a large pre-existing code, the Cardiac Arrhythmia Research Package (CARP), with very minor perturbation of the code base. Overall, bidomain simulations were sped up by a factor of 11.8 to 16.3 in benchmarks running on 6-20 GPUs compared to the same number of CPU cores. To match the fastest GPU simulation which engaged 20 GPUs, 476 CPU cores were required on a national supercomputing facility.
Autism, episodic memory, and moral exemplars

Abstract This paper presents a challenge for exemplar theories of moral concepts. Some have proposed that we acquire moral concepts by way of exemplars of actions that are prohibited as well as of actions that are required, and we classify newly encountered actions based on their similarity to these exemplars. Judgments of (im)permissibility then follow from these exemplar-based classifications. However, if this were true, then we would expect that individuals who lacked, or were deficient in, the capacity to form or access exemplars of this kind would be similarly deficient in the ability to classify new actions according to them, and this relative inability would be manifested in the moral judgments made by such individuals. However, there is reason to suspect, I think, that a number of individuals who have been diagnosed with Autism Spectrum Disorder (ASD) actually have the deficiencies I have described here but are nevertheless fully able to make sound moral judgments. If this is so, then it must be the case that classifying actions as instances of a given moral concept and making judgments based on said classification does not rely solely on exemplars.
Competition when Consumers have Switching Costs: An Overview with Applications to Industrial Organization, Macroeconomics, and International Trade

We survey recent work on competition in markets in which consumers have costs of switching between competing firms' products. In a market with switching costs (or "brand loyalty"), a firm's current market share is an important determinant of its future profitability. We examine how the firm's choice between setting a low price to capture market share, and setting a high price to harvest profits by exploiting its current locked-in customers, is affected by the threat of new entry, interest rates, exchange rate expectations, the state of the business cycle, etc. We also discuss the causes of switching costs; explain introductory offers and price wars; examine industry profits; and analyse firms' product choices. Moreover, we argue that switching costs between suppliers help explain both the existance of multi-product firms and the nature of competition between such firms.
Validation of Suitable Reference Genes for Expression Studies in Different Pilocarpine-Induced Models of Mesial Temporal Lobe Epilepsy

It is well recognized that the reference gene in a RT-qPCR should be properly validated to ensure that gene expression is unaffected by the experimental condition. We investigated eight potential reference genes in two different pilocarpine PILO-models of mesial temporal lobe epilepsy (MTLE) performing a stability expression analysis using geNorm, NormFinder and BestKepeer softwares. Then, as a validation strategy, we conducted a relative expression analysis of the Gfap gene. Our results indicate that in the systemic PILO-model Actb, Gapdh, Rplp1, Tubb2a and Polr1a mRNAs were highly stable in hippocampus of rats from all experimental and control groups, whereas Gusb revealed to be the most variable one. In fact, we observed that using Gusb for normalization, the relative mRNA levels of the Gfap gene differed from those obtained with stable genes. On the contrary, in the intrahippocampal PILO-model, all softwares included Gusb as a stable gene, whereas B2m was indicated as the worst candidate gene. The results obtained for the other reference genes were comparable to those observed for the systemic Pilo-model. The validation of these data by the analysis of the relative expression of Gfap showed that the upregulation of the Gfap gene in the hippocampus of rats sacrificed 24 hours after status epilepticus (SE) was undetected only when B2m was used as the normalizer. These findings emphasize that a gene that is stable in one pathology model may not be stable in a different experimental condition related to the same pathology and therefore, the choice of reference genes depends on study design.
Growth of hippocampal mossy fibers: A lesion and coculture study of organotypic slice cultures

In hippocampal slice cultures, the mossy fibers from the dentate granule cells project as normally to cells in the dentate hilus (CA4) and the hippocampal CA3 pyramidal cells. After lesions in vivo and intracerebral transplantation, the mossy fibers can alter their normal distribution within CA3 and even contact CA1 pyramidal cells. The present study examined whether similar changes could be induced in the more simple, virtual two‐dimensionally organized slice cultures. For this purpose slices of 7‐day‐old hippocampal were prepared and subjected to one of the two following manipulations: (1) transection of the mossy fiber layer in CA3 or (2) rearrangement of the geometrical relations between the dentate granule cells in their potential targets (CA3 and CA1) by coculturing dentate slices with CA3 or CA1 slices. Two to 8 weeks later the distribution of the mossy fiber system was visualized by histochemical Timm sulphide silver staining of the terminals.
Trends and socioeconomic differences in roll-your-own tobacco use: findings from the ITC Europe Surveys

Objectives To examine if exclusive Roll-Your-Own (RYO) tobacco use relative to factory-made (FM) cigarette use has been rising over time, to determine the extent to which economic motives and perceptions that RYO cigarettes are less harmful act as primary motivations for use, and to examine the association of income and education with the level of RYO tobacco use among smokers in four European countries. Methods Data were obtained from the International Tobacco Control (ITC) Europe Surveys, and a cohort sample of 7070 smokers from the Netherlands, Germany, France and UK were interviewed between June 2006 and December 2012. Generalised estimating equations (GEE) were used to assess trends in RYO use, and whether RYO consumption varied by socioeconomic variables. Results Exclusive RYO use over the study period has increased significantly in the UK from 26.4% in 2007 to 32.7% in 2010 (p<0.001); France from 12.2% in 2006 to 19.1% in 2012 (p<0.001); and Germany from 12.7% in 2007 to 18.6% in 2011 (p=0.031), with increased borderline significantly in the Netherlands (31.7% to 34.3%, p=0.052), from 2008 to 2010. Over three-quarters of users in each of the study countries indicated that lower price was a reason why they smoked RYO. Just over a fourth of smokers in the UK, less than a fifth in France, and around a tenth in Germany and the Netherlands believed that RYO is healthier. Compared with exclusive FM users, exclusive RYO users were more likely to have lower incomes and lower education. Conclusions Effective tobacco tax regulation is needed in the European Union and elsewhere to eliminate or reduce the price advantage of RYO tobacco. Additional health messages are also required to correct the misperception that RYO tobacco is healthier than FM cigarettes.
Interactions within and between Corticostriatal Loops during Component Processes of Category Learning

We examined dynamic interactions between cortex and BG during stimulus–response and feedback processing phases of categorization. First, we dissociated stimulus–response processing from feedback processing using “jittered” intervals of time between response and feedback to examine how each recruits the four primary corticostriatal loops (motor, executive, visual, and motivational). Second, we examined dynamic interactions within and between corticostriatal loops using Granger causality mapping. On each trial, subjects viewed one of six abstract visual stimuli, pressed a button indicating category membership, and then received feedback as to whether the decision was right or wrong. Stimulus–response processing was associated with greater activity in the visual loop, whereas feedback processing resulted in activity in the executive loop that was sensitive to feedback valence. Granger causality mapping showed patterns of directed influence within corticostriatal loops and between loops from the motor to the executive, to the visual, and finally to the motivational loop. These patterns of interaction are consistent with functional integration of motor processing in the motor loop with feedback processing in the executive loop and maintenance of stimulus–response history for future responses in the motivational loop.
Correlative multi-label video annotation

Automatically annotating concepts for video is a key to semantic-level video browsing, search and navigation. The research on this topic evolved through two paradigms. The first paradigm used binary classification to detect each individual concept in a concept set. It achieved only limited success, as it did not model the inherent correlation between concepts, e.g., urban and building. The second paradigm added a second step on top of the individual concept detectors to fuse multiple concepts. However, its performance varies because the errors incurred in the first detection step can propagate to the second fusion step and therefore degrade the overall performance. To address the above issues, we propose a third paradigm which simultaneously classifies concepts and models correlations between them in a single step by using a novel Correlative Multi-Label (CML) framework. We compare the performance between our proposed approach and the state-of-the-art approaches in the first and second paradigms on the widely used TRECVID data set. We report superior performance from the proposed approach.
Activation of the anterior cingulate cortex by thalamic stimulation in patients with chronic pain: a positron emission tomography study.

OBJECT Deep brain stimulation (DBS) of the sensory thalamus has been used to treat chronic, intractable pain. The goal of this study was to investigate the thalamocortical pathways activated during thalamic DBS. METHODS The authors compared positron emission tomography (PET) images obtained before, during, and after DBS in five patients with chronic pain. Two of the five patients reported significant DBS-induced pain relief during PET scanning, and the remaining three patients did not report any analgesic effect of DBS during scanning. The most robust effect associated with DBS was activation of the anterior cingulate cortex (ACC). An anterior ACC activation was sustained throughout the 40 minutes of DBS, whereas a more posteriorly located ACC activation occurred at a delay after onset of DBS, although these activations were not dependent on the degree of pain relief reported during DBS. However, implications specific to the analgesic effect of DBS require further study of a larger, more homogeneous patient population. Additional effects of thalamic DBS were detected in motor-related regions (the globus pallidus, cortical area 4, and the cerebellum) and visual and association cortical areas. CONCLUSIONS The authors demonstrate that the ACC is activated during thalamic DBS in patients with chronic pain.
[Study on aberration in histone methylation and acetylation in acute leukemia].

OBJECTIVE To study the aberration in histone H3K4 and H3K9 methylation and H3 and H4 acetylation in human acute leukemia (AL) cells. METHODS The histone H3K4 and H3K9 methylation and H3 and H4 acetylation were detected by Western blot in 34 AL patients and 13 controls (9 non leukemia patients, 4 healthy volunteers). RESULTS The level of H3K4 methylation was significantly lower in 19 AL patients than in non leukemia (0.220 ± 0.096 vs 0.447 ± 0.186, P < 0.01), while the level of H3K9 methylation was significantly higher (0.409 ± 0.106 vs 0.168 ± 0.015, P < 0.01); Both level of histone H3 and H4 acetylation in 15 AL patients were significantly lower (H3: 0.128 ± 0.013 vs 0.386 ± 0.104, H4: 0.096 ± 0.008 vs 0.341 ± 0.096, respectively, both P < 0.01). CONCLUSION Aberration of histone methylation and deficient histone acetylation in AL may represent the markers for an aberrant post-translational modification of histones and chromatin structure. It might be a potential epigenetic target for anti-leukemia agent.
Interconnections between the prefrontal cortex and the premotor areas in the frontal lobe

We examined interconnections between a portion of the prefrontal cortex and the premotor areas in the frontal lobe to provide insights into the routes by which the prefrontal cortex gains access to the primary motor cortex and the central control of movement. We placed multiple injections of one retrograde tracer in the arm area of the primary motor cortex to define the premotor areas in the frontal lobe. Then, in the same animal, we placed multiple injections of another retrograde tracer in and around the principal sulcus (Walker's area 46). This double labeling strategy enabled us to determine which premotor areas are interconnected with the prefrontal cortex.