Miracle-dz/UniFAR-FTUs huggingface dataset:
Medical examination for health of all athletes replacing the need for gender verification in international sports. The International Amateur Athletic Federation Plan.

FOR DECADES, success in competitive international sports has been fostered to promote national prestige and even to support superiority of certain political systems. (The former German Democratic Republic is but one prominent example of a nation in which high-level competitive sports were explicitly chosen as a vehicle to enhance a newly formed nation's identity. Other countries naturally sought to meet the competition; thus, a quasi "arms race" in sports developed.) Given the great national prestige engendered and the considerable expenditures involved in international competitive sports, it is not surprising that individual athletes or even nations were unable to resist the temptation of using illicit methods to "win at all costs. " One prominent example of cheating is doping, usually with drugs. Another type of cheating, namely, the possibility that men may masquerade as women in women's events, was widely discussed in the early 1960s. For editorial comment see p 853. To
Integrated Water Management by Urban Poor Women: A Nigerian Slum Experience

A study was carried out on the integrated water management in an urban poor community in Ibadan, Nigeria. This community with a population of 20 938 is located in the Koloko-Aiyekalearea under the North East Local Government occupying an area of 0.97 km2. They engage mostly in trading, farming and some have taken up the civil service and teaching professions. Shallow wells are their main water source supplemented by rain, tap and other commercial sources. Sanitation is poor, characterized by spread of wastewater on streets and unkempt open drains, and streets littered with refuse and animal dung. An intervention study covering a period of over 18 months was undertaken involving 324 women to improve the water quality, to lay a hygienic drainage system, and to use the wastewater for backyard or community farming. Simple storage of water for prolonged periods, solar radiation of stored water, and pot chlorination of wells were tried for the improvement of water quality. The merits of these methods were asses.
Does Ownership Type Matter for Corporate Social Responsibility?

Manuscript Type: Empirical. Research Question/Issue: This study examines how different types of owners relate to corporate social responsibility (CSR). Research Findings/Insights: We use firm‐level data for more than 600 European firms from 16 countries and 35 industries for 2005. We find that ownership by employees, individuals, and firms is associated with relatively poor corporate social policies of the firms they invest in. In contrast, the holdings by banks and institutional investors as well as those by the state appear to be neutral in this respect. Theoretical/Academic Implications: This study develops and tests notions as to how particular types of owners could have a specific impact on the firm's CSR. The relative value put upon CSR can differ along different types of owners. This results from their different economic roles in society. The study provides empirical support for the relationship between ownership type and CSR policies in Europe. As such, it provides a new focus on the content of shareholder activism, namely that shareholder background has to be taken into account. Another innovation is that we show it is important to account for the multidimensional nature of CSR as well. Practitioner/Policy Implications: This study offers a new perspective for firms, investors and other stakeholders about portfolio investments and CSR. As we find that it does matter who invests, corporate engagement policies can be directed much more effectively. In particular, the investors who act as intermediaries appear to be the most sensitive ones in this respect. Our study suggests that firms should take the background of their shareholders into account in relation to their CSR strategy. Furthermore, our study helps stakeholders to direct their efforts more effectively. It also provides a perspective for executives and investment managers of multinational firms to consider if and how they can create social value next to shareholder value. We suggest that policy makers promote the transparency of ownership information as well as that of CSR performance.
Transcriptomic responses to sodium chloride‐induced osmotic stress: A study of industrial fed‐batch CHO cell cultures

The rapidly expanding market for monoclonal antibody and Fc‐fusion‐protein therapeutics has increased interest in improving the productivity of mammalian cell lines, both to alleviate capacity limitations and control the cost of goods. In this study, we evaluated the responses of an industrial CHO cell line producing an Fc‐fusion‐protein to hyperosmotic stress, a well‐known productivity enhancer, and compared them with our previous studies of murine hybridomas (Shen and Sharfstein, Biotechnol Bioeng. 2006;93:132–145). In batch culture studies, cells showed substantially increased specific productivity in response to increased osmolarity as well as significant metabolic changes. However, the final titer showed no substantial increase due to the decrease in viable cell density. In fed batch cultures, hyperosmolarity slightly repressed the cellular growth rate, but no significant change in productivity or final titer was detected. To understand the transcriptional responses to increased osmolarity and relate changes in gene expression to increased productivity and repressed growth, proprietary CHO microarrays were used to monitor the transcription profile changes in response to osmotic stress. A set of osmotically regulated genes was generated and classified by extracting their annotations and functionalities from online databases. The gene list was compared with results previously obtained from similar studies of murine‐hybridoma cells. The overall transcriptomic responses of the two cell lines were rather different, although many functional groups were commonly perturbed between them. Building on this study, we anticipate that further analysis will establish connections between productivity and the expression of specific gene(s), thus allowing rational engineering of mammalian cells for higher recombinant‐protein productivity. © 2010 American Institute of Chemical Engineers Biotechnol. Prog. , 2010
Sectoral Interdependencies and Key Sectors in the Romanian, Hungarian and Slovak Economy – An Approach Based on Input-Output Analysis

Abstract The aim of this paper is to analyse sectoral interdependencies and to identify the key sectors in the Romanian, Hungarian and Slovak economy, drawing a comparison between these three countries. In order to do these investigations, input-output analysis is applied, as it is based on a model which presents interactions between sectors of the economy. This method can also be used for determining the role of each sector in the national economy regarding its contribution to the total output, incomes, exportimport and so on, and for quantifying direct and indirect impact on the whole economy caused by any change produced in a sector’s activity. As the results of the analyses show, several similarities and differences appear in the economic structure, the sectoral interdependencies and the key sectors of the analysed countries. For example, in Romania, intersectoral transactions are axing mainly on the Trade and Manufacturing sectors, while in Hungary and Slovakia on the Manufacturing and Other professional, scientific and technical services sectors. Key sectors - identified by applying output and income backward linkages - also differ as in Romania the output backward linkage is the largest in the case of the Trade sector, in Hungary, in the Food sector and in Slovakia in the Electricity, gas, water and waste management sector. In the case of the income linkages, Social, collective and personal services rank in the first place in all three countries
THE IRON FIST IN THE VELVET GLOVE: MANAGEMENT AND ORGANIZATION IN JAPANESE MANUFACTURING TRANSPLANTS IN WALES

This paper assesses the transferability of a Japanese form of manufacturing organization to an alien institutional environment - the Principality of Wales in the UK. After characterizing what we mean by a ‘Japanese form of manufacturing organization’ and the arrival of Japanese companies in Wales, we describe the forms of organization, day-to-day management and working practices which have been established. Our conclusion is that the Japanese form of manufacturing organization has been re-created on Welsh soil, and that any ‘adaptations’ are not such as to alter the fundamental features of the new organizational form.
Cointegration and the Monetary Exchange Rate Model Revisited

To test for cointegration in a multiple of countries a number of procedures are available: a panel vector error correction framework, a panel-data version of the Engle and Granger (1987) two-step procedure and the Johansen (1991) trace statistic. We apply these three methods on two four-country datasets consisting of the exchange rate data and monetary fundamentals relative to both the United Kingdom and the United States to test the empirical validity of the monetary exchange rate model. Of the three aforementioned methods only the panel vector error correction approach provides evidence for the validity of both the cointegration restriction as well as the long-run parameter restrictions of the monetary model, irrespective of the numeraire country. Copyright 2002 by Blackwell Publishing Ltd
A Comparative Study of Satellite andGround-Based Vineyard Phenology

Grapevine phenology observations are essential for ecological adaptability of grape varieties, crop management and crop modelling. Phenological events have traditionally been ground based, with observations mainly providing information concerning grape varieties over a limited spatial area and few in- season observations. Time-series of satellite imagery can rapidly provide a synoptic and objective view of grape vegetation dynamics that may be used for vineyard management. Ten-day VEGETATION image composites from 1999 to 2007 were used to examine temporal profile in the Normalized Difference Vegetation Index (NDVI) and their relationship with ground based observation of grapevine phenology. In Portugal is Douro wine region, 2 suitable tests sites with over 70% or more of their area occupied by grapevines were selected. A number of NDVI metrics were obtained for each year through logistic model adjusted to NDVI time series after noise reduction using a Savitzky-Golay filter. The comparison of ground-based vineyard phenology and satellite-derived flowering, show an average spread deviation of 3 days. The satellite derived full canopy date was significantly correlated to the veraison date (r=0.87; n=7; p<0.02). The data set provided by the VEGETATION sensor proved to be a valuable tool for vineyard monitoring, mainly for inter-annual comparisons on regional scale.
The Strategic Choice of Managerial Incentives

Do firms with separate owners and managers maximize profits? We address this question for an oligopoly where managers compete in quantities or prices, as in the Cournot or Bertrand models, and owners choose their managers' incentives. We find that there is a strategic aspect in the problem of selecting incentives and that profit-maximizing behavior does not result. In particular, in the oligopoly we study, the behavior of firms competing in quantity (price) more closely resembles perfectly competitive (collusive) behavior than Cournot (Bertrand) behavior.
Seroepidemiology and assessment of risk factors for the spread of avian influenza in birds in two Nigerian states

Abstract Despite modified stamping out eradication policy adopted in Nigeria, there was resurgence in 2015 of highly pathogenic avian influenza (HPAI) H5N1 with greater infectivity. A survey of the risk of spread of HPAI in two HPAI‐infected and ‐uninfected Nigerian states were studied. A cross‐sectional study to detect avian influenza (AI) H5 antibodies was conducted using haemagglutination inhibition (HI) test and enzyme‐linked immunosorbent assay (ELISA). A total of 950 birds’ sera were tested for AI H5 antibodies. Questionnaires were also administered to evaluate risks of AI spread in two states of Nigeria in 2013. AI H5 seroprevalence of 3% and 5% were obtained in Bauchi and Gombe states, respectively. Free flying and captive wild birds had 15% and 11% seroprevalence, respectively. Ninety‐two per cent AI awareness and 90% preparedness to report outbreaks of poultry diseases were recorded. Veterinary personnel, radio and television contributed 87% to HPAI awareness. Of the 10 risk categories evaluated, Gombe state had 3 moderate and 1 high risk of AI virus spread. Bauchi state recorded 5 moderate and 1 high risk of AI virus spread. Chi‐square analysis showed associations of altitude, temperature, rainfall and presence of live bird markets (LBMs) (P < 0.05) to AI seroprevalence. Odds ratio at 95% CI (1.313–6.333) indicated LBMs presence to be three times more likely to influence AI occurrence. HPAI H5N1 resurged in many states and occurred for the first time in Gombe state in 2015. Veterinary personnel, radio and television may be reliable in changing farmers’ attitudes to adopt good biosecurity practices.
On the Turnover of Business Firms and Business Managers

This paper develops a model of small business failure and sale that is motivated by recent evidence concerning how the failure and sale of small businesses vary with the age of the business and the tenure of the manager. This evidence motivates two key features of the model: a match between the manager and the business, and characteristics of businesses that survive beyond the current match. The parameters of the model are estimated, and the properties of this parametric model are studied. This analysis results in a simple characterization of the workings of the small business sector.
Caveolin-1 Is Not Required for Murine Intestinal Cholesterol Transport*

Caveolin-1 (CAV1) is the structural protein of the filamentous coat that decorates the cytoplasmic surface of each caveola. Cell culture studies have implicated CAV1 in playing an important role in intracellular cholesterol trafficking. In addition, it has been reported that CAV1 forms a detergent-resistant protein complex with Annexin-2 in enterocytes that can be disrupted by the cholesterol absorption inhibitor ezetimibe, suggesting a possible role for CAV1 in cholesterol absorption. In this report, we have evaluated cholesterol homeostasis in Cav1 knock-out mice. Deletion of CAV1 does not result in either a compensatory increase of CAV2 or CAV3 in intestine. In addition, Cav1 knock-out mice display normal mRNA and protein levels of Annexin-2 or the putative cholesterol transport protein Niemann-Pick C1-like 1 (NPC1L1) in proximal intestinal mucosa. Fractional cholesterol absorption and fecal neutral sterol excretion are statistically similar in Cav1 knock-out mice and their wild-type littermates. Moreover, oral administration of ezetimibe is equally effective in decreasing cholesterol absorption in Cav1 null mice and wild-type controls. The mRNA expression levels of genes sensitive to intracellular cholesterol concentration (ATP-binding cassette transporters ABCA1 and ABCG5, hydroxymethylglutaryl-CoA synthase and the LDL receptor) are similarly altered in the proximal intestinal mucosa of Cav1 null and wild-type mice following ezetimibe treatment. These results demonstrate that CAV1 is not required for cholesterol absorption or ezetimibe sensitivity in the mouse.
Susceptibility of anaerobic bacteria to nine antimicrobial agents and demonstration of decreased susceptibility of Clostridium perfringens to penicillin

The activity of moxalactam, cefoxitin, cephalothin, cefamandole, chloramphenicol, clindamycin, metronidazole, and ticarcillin was determined against 344 isolates of anaerobic bacteria. The activity of penicillin G was determined as well for 234 isolates not of the Bacteroides fragilis group. Moxalactam was more active than cephalothin and cefamandole and slightly less active than cefoxitin. Metronidazole was the most active antimicrobial agent against the B. fragilis group, whereas chloramphenicol was most active overall. Clostridium species were the most resistant group of organisms tested. Relatively high concentrations of penicillin were required to inhibit the C. perfringens strains: 80% at 0.5 U/ml and 100% at 16 U/ml. Our study demonstrates the need for periodic anaerobe susceptibility testing in order to better guide empiric antibiotic therapy.
At least four viral genes contribute to the leukemogenicity of murine retrovirus MCF 247 in AKR mice

Nucleotide sequences encoding gp70, Prp15E, and the U3 region of the long terminal repeat (LTR) distinguish mink cell focus-forming (MCF) retroviruses that can induce leukemia in AKR mice from closely related MCF and ecotropic murine retroviruses that are nonleukemogenic in all inbred mouse strains tested (Lung et al., Cold Spring Harbor Symp. Quant. Biol. 44:1269-1274, 1979; Lung et al., J. Virol. 45:275-290, 1983). We used a set of recombinants constructed in vitro from molecular clones of leukemogenic MCF 247 and nonleukemogenic ecotropic Akv to separate and thereby directly test the role of these genetic elements in disease induction. Leukemogenicity tests of recombinants in AKR mice show that introduction of fragments containing either an MCF LTR or MCF gp70 coding sequences can confer only a very low incidence of disease induction on Akv virus, whereas an MCF type Prp15E alone is completely ineffective. Recombinants with an MCF 247 LTR in combination with MCF Prp15E are moderately oncogenic, whereas those with an MCF 247 LTR plus MCF gp70 coding segment are quite highly leukemogenic. Mice infected with the latter virus show a substantial increase in latent period of disease induction relative to MCF 247; this delay can be reduced when Prp15E, and hence the entire 3' half of the genome, is from MCF 247. Surprisingly, sequences in the 5' half of the genome can also contribute to disease induction. We found a good correlation between oncogenicity and recovery of MCF viruses from thymocytes of injected mice, with early recovery and high titers of MCF in the thymus being correlated with high oncogenicity. This correlation held for recombinants with either an MCF or ecotropic type gp70. Together, these results (i) demonstrate that at least four genes contribute to the oncogenicity of MCF viruses in AKR mice and (ii) suggest that recombinants with only some of the necessary MCF type genes induce leukemia because they recombine to generate complete MCF genomes. Although neither Akv nor MCF 247 is leukemogenic in NFS mice, recombinant viruses whose gp70 gene was derived from Akv but whose LTRs were derived from MCF 247 induced a low incidence of leukemia in this mouse strain.
Community stability and selective extinction during the Permian-Triassic mass extinction

No precedent Human activities are creating a mass extinction event. The intensity of this event is unprecedented during human times, but there have been several comparable events during Earth's history. Roopnarine and Angielczyk examined one of the largest, the Permian-Triassic Extinction (see the Perspective by Marshall). The structure and diversity of communities were key predictors of stability through the event. Furthermore, extinctions were not random, with smaller-bodied species being more prone to extinction. This pattern is in direct contradiction to the patterns seen in our current extinction. Thus, the current anthropogenically driven extinction is fundamentally different from previous catastrophic extinctions. Science, this issue p. 90; see also p. 38 The Permian-Triassic extinction event 252 million years ago was fundamentally different from the current, human-caused, extinctions. [Also see Perspective by Marshall] The fossil record contains exemplars of extreme biodiversity crises. Here, we examined the stability of terrestrial paleocommunities from South Africa during Earth's most severe mass extinction, the Permian-Triassic. We show that stability depended critically on functional diversity and patterns of guild interaction, regardless of species richness. Paleocommunities exhibited less transient instability—relative to model communities with alternative community organization—and significantly greater probabilities of being locally stable during the mass extinction. Functional patterns that have evolved during an ecosystem's history support significantly more stable communities than hypothetical alternatives.
Corruption and Auctions

We investigate the outcome of an auction where the auctioneer approaches one of the two existing bidders and offers an opportunity for him to match his opponent's bid in exchange for a bribe. In particular, we examine two types of corruption arrangements. In the first case, the auctioneer approaches the winner to offer the possibility of a reduction in his bid to match the loser's bid in exchange for a bribe. In the second arrangement, the auctioneer approaches the loser and offers him the possibility of matching the winner's bid in exchange for a bribe. While oral auctions are corruption free under the two arrangements, corruption affects both bidding behavior, efficiency and the seller's expected revenue in a first-price auction.
Institution Design in Social Dilemmas: How to Design If You Must?

Considerable experimental evidence has been collected on how to solve the public-good dilemma. In a 'first generation' of experiments, this was done by presenting subjects with a pre-specified game out of a huge variety of rules. A 'second generation' of experiments introduced subjects to two different environments and had subjects choose between those. The present study is part of a 'third generation,' asking subjects not only to choose between two environments but to design their own rule sets for the public-good problem. Whereas preceding 'third-generation' experiments had subjects design and improve their strategies for a specified game, this study is the first to make an attempt at answering the question of how people would shape their environment to solve the public-good dilemma were they given full discretion over the rules of the game. We explore this question of endogenous institution design in an iterated design-and-play procedure. We observe a strong usage of punishment and redistribution components, which diminishes over time. Instead, subjects successfully contextualize the situation. Interestingly, feedback on fellow-players’ individual behavior tends to be rendered opaque. On average, rules do improve with respect to the welfare they elicit, albeit only to a limited degree.