Miracle-dz/UniFAR-FTUs huggingface dataset:
22.7 4×25.78Gb/s retimer ICs for optical links in 0.13μm SiGe BiCMOS

To meet increasing demands for server computational power, high-density, multilane links with a data rate exceeding 25Gb/s/lane are needed. An optical transceiver with a retiming capability would significantly enhance the usability of the link by extending the reach. Such optical transceivers should operate without an external clock source since a small form factor is imperative. The optical link we develop has a four-lane configuration that consists of an electrical-to-optical (E/O) converter and an optical-to-electrical (O/E) convertor (Fig. 22.7.1). Both the E/O and O/E convertors are equipped with a per-lane reference-less clock-and-data recovery (CDR) circuit that enables independent operation of each lane. The transceiver pitch is 250μm/lane, which matches the fiber pitch of the optical-fiber array used in the link. Since the jitter added by the CDR should be minimized in retimer applications, an LC-VCO is a preferable choice for clock-signal generation. At this transceiver pitch, however, the coupling through mutual inductances between LC tanks has a significant impact on the CDR characteristics. To address this concern, we analyze the impact of inter-VCO coupling and design the CDR so that the coupling does not affect the CDR performance. Each lane of the E/O convertor consists of a continuous-time linear equalizer (CTLE), a CDR, and a VCSEL driver with a two-tap feed-forward equalizer (FFE) (Fig. 22.7.1). Each lane of the O/E convertor has a trans-impedance amplifier (TIA) stage followed by a limiting amplifier (LA), a CDR, and an electrical-line driver with a two-tap FFE. All the CDRs have an identical design consisting of a flip-flop for the data decision, a selector for bypass-mode operation, a Pottbacker type phase-frequency detector (PFD) [1], a charge pump (CP), a lag-lead filter, and a quadrature LC-VCO (QVCO). During the bypass mode, the CDR loop is set into a power-down mode where the VCO does not oscillate.
Bathymetric particle filter SLAM using trajectory maps

We present an efficient and featureless approach to bathymetric simultaneous localization and mapping (SLAM) that utilizes a Rao–Blackwellized particle filter (RBPF) and Gaussian process (GP) regression to provide loop closures in areas with little to no overlap with previously explored terrain. To significantly reduce the memory requirements (thereby allowing for the processing of large datasets) a novel map representation is also introduced that, instead of directly storing estimates of seabed depth, records the trajectory of each particle and synchronizes them to a common log of bathymetric observations. Upon detecting a loop closure each particle is weighted by matching new observations to the current predictions generated from a local reconstruction of their map using GP regression. Here the spatial correlation in the environment is fully exploited, allowing predictions of seabed depth in areas that may not have been directly observed previously. The results demonstrate how observations of seafloor structure with partial overlap can be used by bathymetric SLAM to improve map self consistency when compared with dead reckoning fused with long-baseline (LBL) observations. In addition we show how mapping corrections can still be achieved even when no map overlap is present.
Who are the children at risk? Lessons learned from measles outbreaks

SUMMARY We investigated a measles outbreak in the Jerusalem district in 2007–2008 (992 cases). Most cases (72·6%) were aged <15 years, 42·9% aged <5 years, and 12·8% were infants aged <1 year. The peak incidence rate was in infants aged 6–12 months (916·2/100 000). This represents a significant shift from former outbreaks in 2003–2004, where the peak incidence was in the 1–4 years age group. Of children aged <5 years the proportion aged 6–12 months tripled (7·7% vs. 25·6%). In a case-control study (74 cases, 148 controls) children who developed measles were less likely to be registered in a well-baby clinic and had lower overall immunization coverage. The differences in proportions for registration, DTaP3 and MMR1 coverage were 35·1%, 48·6% and 80·8%, respectively (all P<0·001). Rising birth order of cases and their siblings was associated with non-registration and non-compliance with MMR immunization. The vulnerability of young infants and the risk markers noted above should be taken into account in planning intervention programmes.
Role of the Cytokine-like Hormone Leptin in Muscle-bone Crosstalk with Aging

The cytokine-like hormone leptin is a classic adipokine that is secreted by adipocytes, increases with weight gain, and decreases with weight loss. Additional studies have, however, shown that leptin is also produced by skeletal muscle, and leptin receptors are abundant in both skeletal muscle and bone-derived mesenchymal (stromal) stem cells. These findings suggest that leptin may play an important role in muscle-bone crosstalk. Leptin treatment in vitro increases the expression of myogenic genes in primary myoblasts, and leptin treatment in vivo increases the expression of microRNAs involved in myogenesis. Bone marrow adipogenesis is associated with low bone mass in humans and rodents, and leptin can reduce marrow adipogenesis centrally through its receptors in the hypothalamus as well as directly via its receptors in bone marrow stem cells. Yet, central leptin resistance can increase with age, and low circulating levels of leptin have been observed among the frail elderly. Thus, aging appears to significantly alter leptin-mediated crosstalk among various organs and tissues. Aging is associated with bone loss and muscle atrophy, contributing to frailty, postural instability, and the incidence of falls. Therapeutic interventions such as protein and amino acid supplementation that can increase muscle mass and muscle-derived leptin may have multiple benefits for the elderly that can potentially reduce the incidence of falls and fractures.
Nanoelectromechanics of suspended carbon nanotubes

We discuss different types of measurements targetting the interplay of mechanical motion with electrical transport in suspended single-wall carbon nanotube devices. In driven resonator experiments, the transversal acoustical vibration mode is detected and identified at room temperature using ac down-mixing techniques. In contrast, low-temperature transport spectroscopy enables the observation of the longitudinal acoustic mode in the quantum limit in single electron tunnelling. This vibrational excitation can also be observed in higher order tunnelling current for appropriate electronic coupling to the leads. Experimental roads towards the quantum limit of the transversal vibration mode—as ultimate quantum-limited beam resonator—are explored, e.g. extending both abovementioned measurement techniques.
PEDF from mouse mesenchymal stem cell secretome attracts fibroblasts

Conditioned medium (secretome) derived from an enriched stem cell culture stimulates chemotaxis of human fibroblasts. These cells are classified as multipotent murine mesenchymal stromal cells (mMSC) by immunochemical analysis of marker proteins. Proteomic analysis of mMSC secretome identifies nineteen secreted proteins, including extracellular matrix structural proteins, collagen processing enzymes, pigment epithelium‐derived factor (PEDF) and cystatin C. Immunodepletion and reconstitution experiments show that PEDF is the predominant fibroblast chemoattractant in the conditioned medium, and immunofluorescence microscopy shows strong staining for PEDF in the cytoplasm, at the cell surface, and in intercellular space between mMSCs. This stimulatory effect of PEDF on fibroblast chemotaxis is in contrast to the PEDF‐mediated inhibition of endothelial cell migration, reported previously. These differential functional effects of PEDF toward fibroblasts and endothelial cells may serve to program an ordered temporal sequence of scaffold building followed by angiogenesis during wound healing. J. Cell. Biochem. 104: 1793–1802, 2008. © 2008 Wiley‐Liss, Inc.
Biochemical challenge of microbial pathogenicity.

In the past decade there has been a revival of interest in microbial pathogenicity. The reasons for this revival are two-fold. First, infectious disease is still with us despite the impact of the antibiotic era; for example, the rise of bacterial and fungal infections in compromised patients and the lack of a good general antiviral drug. Second, the subject of microbial pathogenicity is ripe for application of techniques of biochemistry, molecular biology and genetics that have developed in other areas of biology over the past twenty years; and the potential of these techniques is particularly attractive to young people, who are entering the field in increasing numbers. In this lecture I shall survey the methods and difficulties of investigating microbial pathogenicity and what we know of the main aspects of the subject at the molecular level. I shall use bacteria as examples because more is known about them than other types of microbes. Lack of space prevents quoting original papers in such a wide-ranging task; in most cases reference is made to authorative reviews.
LSR defines cell corners for tricellular tight junction formation in epithelial cells

Epithelial cell contacts consist of not only bicellular contacts but also tricellular contacts, where the corners of three cells meet. At tricellular contacts, tight junctions (TJs) generate specialized structures termed tricellular TJs (tTJs) to seal the intercellular space. Tricellulin is the only known molecular component of tTJs and is involved in the formation of tTJs, as well as in the normal epithelial barrier function. However, the detailed molecular mechanism of how tTJs are formed and maintained remains elusive. Using a localization-based expression cloning method, we identified a novel tTJ-associated protein known as lipolysis-stimulated lipoprotein receptor (LSR). Upon LSR knockdown in epithelial cells, tTJ formation was affected and the epithelial barrier function was diminished. Tricellulin accumulation at the tricellular contacts was also diminished in these cells. By contrast, LSR still accumulated at the tricellular contacts upon tricellulin knockdown. Analyses of deletion mutants revealed that the cytoplasmic domain of LSR was responsible for the recruitment of tricellulin. On the basis of these observations, we propose that LSR defines tricellular contacts in epithelial cellular sheets by acting as a landmark to recruit tricellulin for tTJ formation.
Incorporation of a rotavirus vaccine into the national immunisation schedule in the United Kingdom: a review

Introduction: Rotavirus, the commonest cause of severe acute gastroenteritis in infants and young children worldwide, imposes a large health and economic burden on the British society, accounting for an estimated 14,300 hospitalisations and 133,000 general practitioner consultations each year among children aged < 5 years in England and Wales alone. Following a tender process, an attenuated human rotavirus vaccine, Rotarix (GlaxoSmithKline Biologicals, Belgium), was introduced into the UK childhood immunisation programme in 2013. Area covered: This article provides a review of the product profile of the Rotarix vaccine for use in the national immunisation programme in the UK from an expert perspective. Expert opinion: This single G1P[8] strain-based human rotavirus vaccine has demonstrated high efficacy in preventing severe rotavirus gastroenteritis in the first 3 years of life in middle- and high-income countries. In countries that have adopted rotavirus vaccine in childhood immunisation programmes, indirect benefits (herd protection) have been observed among older, unvaccinated children and adults. When the first dose is administered between 6 and 14 weeks of age and the last dose by 24 weeks of age, Rotarix carries a small risk of intussusception within the week of vaccination. However, this small risk may at most result in a negligible population attributable risk at the end of the first year of life. Overall, the rotavirus immunisation programme is expected to provide substantial health benefits to the UK population.
Phonological and Semantic Cues to Learning from Word-Types

Word-types represent the primary form of data for many models of phonological learning, and they often predict performance in psycholinguistic tasks. Word-types are often tacitly defined as phonologically unique words. Yet, an explicit test of this definition is lacking, and natural language patterning suggests that word meaning could also act as a cue to word-type status. This possibility was tested in a statistical phonotactic learning experiment in which phonological and semantic properties of word-types varied. During familiarization, the learning targets—word-medial consonant sequences—were instantiated either by four related word-types or by just one word-type (the experimental frequency factor). The expectation was that more word-types would lead participants to generalize the target sequences. Regarding semantic cues, related word-types were either associated with different referents or all with a single referent. Regarding phonological cues, related word-types differed from each other by one, two, or more phonemes. At test, participants rated novel wordforms for their similarity to the familiarization words. When participants heard four related word-types, they gave higher ratings to test words with the same consonant sequences, irrespective of the phonological and semantic manipulations. The results support the existing phonological definition of word-types.
Polynomial method for Procedural Terrain Generation

A new method is presented, allowing for the generation of 3D terrain and texture from coherent noise. The method is significantly faster than prevailing fractal brownian motion approaches, while producing results of equivalent quality. The algorithm is derived through a systematic approach that generalizes to an arbitrary number of spatial dimensions and gradient smoothness. The results are compared, in terms of performance and quality, to fundamental and efficient gradient noise methods widely used in the domain of fast terrain generation: Perlin noise and OpenSimplex noise. Finally, to objectively quantify the degree of realism of the results, a fractal analysis of the generated landscapes is performed and compared to real terrain data.
A Case of Nocardia farcinica Pneumonia and Mediastinitis in an Immunocompetent Patient

Nocardia species are aerobic, gram-positive pathogens found worldwide in soil. Nocardia is considered an opportunistic pathogen, and its infection mostly occurs in immunocompromised patients. We report a case of Nocardia farcinica induced mediastinitis and pneumonia that occurred in a 64-year-old male patient who had no significant medical history except for hypertension. He visited another hospital with a complaint of dyspnea and left chest wall pain. The symptoms arose 7 days ago without any trauma and they worsened. A mediastinal mass was found on computed tomography scan. After being transferred to our hospital for further evaluation, he was diagnosed with mediastinitis and pneumonia. As N. farcinica was found to be the causative organism by 16S rRNA sequencing, proper antibiotic therapy including trimethoprim/sulfamethoxazole was initiated immediately. After this, the patient improved and he was discharged. If an infection has a disseminating course, nocardiosis cannot be excluded even in immunocompetent patients. Once the diagnosis is established, prompt antibiotic therapy should be performed based on the severity.
The SENSEI Annotated Corpus: Human Summaries of Reader Comment Conversations in On-line News

Researchers are beginning to explore how to generate summaries of extended argumentative conversations in social media, such as those found in reader comments in on-line news. To date, however, there has been little discussion of what these summaries should be like and a lack of humanauthored exemplars, quite likely because writing summaries of this kind of interchange is so difficult. In this paper we propose one type of reader comment summary – the conversation overview summary – that aims to capture the key argumentative content of a reader comment conversation. We describe a method we have developed to support humans in authoring conversation overview summaries and present a publicly available corpus – the first of its kind – of news articles plus comment sets, each multiply annotated, according to our method, with conversation overview summaries.
Pulp and paper mill effluents induce distinct gene expression changes linked to androgenic and estrogenic responses in the fathead minnow (Pimephales promelas)

Although effluent treatment systems within pulp and paper mills remove many toxicants and improve wastewater quality, there is a need to understand and quantify the effectiveness of the treatment process. At a combined news and kraft pulp and paper mill in northwestern Ontario, Canada, fathead minnow (FHM) reproduction and physiology were examined before, during, and after a short‐term (6‐d) exposure to 10% (v/v) untreated kraft mill effluent (UTK), 25% (v/v) secondary treated kraft mill effluent (TK), and 100% (v/v) combined mill outfall (CMO). Although UTK exposure significantly decreased egg production, neither TK nor CMO caused any reproductive changes. The expression of six genes responsive to endocrine‐disrupting compounds, stress, or metals was then examined in livers of these fish using real‐time polymerase chain reaction. In female FHMs, none of the three effluents induced significant expression changes in any genes investigated. By contrast, in males there were significant increases in the mRNA levels of androgen receptor, estrogen receptor (ER) β, and cytochrome P4501A (CYP1A) upon UTK and TK exposure but no changes in ERα or vitellogenin (VTG) gene expression, whereas CMO exposure significantly increased the mRNA levels of ERα, VTG, and CYP1A. Together, these results suggest that kraft effluent before and after biological treatment contained compounds able to induce androgenic effects in FHMs, and that combination of kraft and newsmill effluents eliminated the androgenic compounds while inducing distinct and significant patterns of gene expression changes that were likely due to estrogenic compounds produced by the newsmill. Environ. Toxicol. Chem. 2010;29:430–439. © 2009 SETAC
Emergency Department During Long Public Holidays

SUMMARY Objectives The purpose of this study is to determine the impact of the expected increase in the volume of patient visits in the emergency department during holiday periods on physicians' tendencies regarding test and consultation requests as well as on the length of time patients stay in the emergency department. Methods The study groups included all of the patients who visited the emergency department during the nine-day public holiday (Eid al-Adha, a religious festival of sacrifice) celebrations and a nine-day non-holiday “normal” period. The patients' demographic information, reasons for their visits, comorbid diseases, whether or not they had undergone laboratory and screening tests, consultations, length of stay, and the way their visits ended were compared statistically. Results Of the 6353 patients enrolled in the study, 3523 (55.5%) were seen in the emergency department during the holiday period, while 2830 (45.5%) were seen during the non-holiday period (p≤0.001). During the holiday period, there was a 1.9% decrease in laboratory test requests (p=0.108), a 7.7% increase in radiology examination requests (p≤0.001), and a 1.2% increase in consultation requests (p=0.063). The patients' length of stay during the holiday period was 55.9±75.3 minutes and was 56.3±71.9 minutes during the non-holiday period (p=0.819). The length of time for the patients who underwent tests or consultations was 88.6±92.8 minutes during the holiday period and 92.6±87.5 minutes during the non-holiday period (p=0.224). Conclusions As expected, the number of patient visits to the emergency department increased during the holiday period, but this increase did not lead to a similar increase in test and consultation requests by the physicians, except for radiology examination requests. In addition, the length of time that patients stayed in the emergency department was not affected by the increase in the volume of patient visits during the holiday period.
Assessment of pulmonary functions in obese adolescent boys

Background: Obesity is rapidly escalating in India in all age groups. School-based data indicate a prevalence rate between 5.6% and 24% in children and adolescents. Adolescent obesity is associated with a greater long-term risk of hypertension and type 2 diabetes mellitus in adulthood. However, studies investigating pulmonary functions in obese adolescents are few. The present study assesses pulmonary functions in obese adolescent boys from a school in Baroda city, Gujarat. Aims: (i) To assess the dynamic lung functions in obese adolescent boys. (ii) To determine the predominant lung function impairment associated with obesity in adolescence. Materials and Methods: Dynamic lung functions were measured in 30 obese adolescent boys and an equal number of age-matched controls using MEDI:SPIRO software (Maestros Mediline Systems Ltd., Navi Mumbai, India). Results: Forced expiratory volume in the 1st second (FEV1)/forced vital capacity (FVC) and maximum voluntary ventilation (MVV) were significantly decreased in the obese group (P < 0.001). Pulmonary functions in the study population correlated negatively with various indices of obesity, viz. weight, body mass index (BMI), waist circumference, hip circumference, and waist-to-hip ratio. The strongest negative correlation was between BMI and FEV1/FVC (P < 0.001) and between BMI, MVV, and Forced Expiratory Flow (FEF25–75%) (P < 0.001). Waist-to-hip ratio in the study population correlated negatively with MVV (P < 0.01), but not with FEV1/FVC. Conclusions: Lung function impairment, particularly decreased MVV and reduced FEV1/FVC ratio, is associated with obesity in adolescence. In addition, pulmonary functions deteriorate with increasing obesity in adolescence and correlate negatively with various indices of obesity, viz. weight, BMI, waist circumference, hip circumference, and waist-to-hip ratio. This study reveals another health hazard associated with obesity and highlights the need to aggressively reduce weight at a younger age.
Riesz transforms associated to Schr\"odinger operators with negative potentials

The goal of this paper is to study the Riesz transforms $\na A^{-1/2}$ where $A$ is the Schr\"odinger operator $-\D-V, V\ge 0$, under different conditions on the potential $V$. We prove that if $V$ is strongly subcritical, $\na A^{-1/2}$ is bounded on $L^p(\R^N)$, $N\ge3$, for all $p\in(p_0';2]$ where $p_0'$ is the dual exponent of $p_0$ where $2<\frac{2N}{N-2}
Immediate post‐doxorubicin drug‐eluting beads chemoembolization Mr Apparent diffusion coefficient quantification predicts response in unresectable hepatocellular carcinoma: A pilot study

To investigate magnetic resonance imaging (MRI) diffusion‐weighted imaging (DWI) of hepatocellular carcinoma (HCC) immediately post‐doxorubicin drug‐eluting beads transcatheter arterial chemoembolization (DEB‐TACE) therapy as an early imaging biomarker of therapy response.