Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins

Protium is the main genus of the Burseraceae family and one of the most common genera in South America, with an important species called “breu. ” Gum and oil-resins of this species are used as tonic and stimulant and for the treatment of ulcers and inflammation. The present study aims to isolate and investigate the anti-inflammatory activity of triterpene compounds isolated from oil-resin of Protium paniculatum. The pentacyclic triterpenes α,β-amyrin, acetylated α,β-amyrin, α,β-amyrone, and brein/maniladiol did not alter the viability of murine J774 macrophages (IC50 > 20 µg/mL), with the exception of mixture of brein/maniladiol which showed moderate cytotoxic activity. Also it was observed that compounds at 10 µg/mL inhibited more than 80% of production of NO•, although only α,β-amyrin was able to inhibit the production of TNF-α (52.03 ± 2.4%). The compounds inhibited the production of IL-6 and induced the production of IL-10 in murine J774 macrophages stimulated by LPS. α,β-Amyrone inhibited the expression of COX-2 and also inhibited the formation of paw or ear edema in rats and mice, having a quick and immediate effect. This study may provide the basis for future investigations on the therapeutic role of α,β-amyrone in treating inflammation.
Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis

Increased risk of developing metabolic syndrome (MetS) has been associated with the circadian clock genes. In this study, we assessed whether 29 circadian clock-related genes (including ADCYAP1, ARNTL, ARNTL2, BHLHE40, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, GSK3B, HCRTR2, KLF10, NFIL3, NPAS2, NR1D1, NR1D2, PER1, PER2, PER3, REV1, RORA, RORB, RORC, SENP3, SERPINE1, TIMELESS, TIPIN, VIP, and VIPR2) are associated with MetS and its individual components independently and/or through complex interactions in a Taiwanese population. We also analyzed the interactions between environmental factors and these genes in influencing MetS and its individual components. A total of 3,000 Taiwanese subjects from the Taiwan Biobank were assessed in this study. Metabolic traits such as waist circumference, triglyceride, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, and fasting glucose were measured. Our data showed a nominal association of MetS with several single nucleotide polymorphisms (SNPs) in five key circadian clock genes including ARNTL, GSK3B, PER3, RORA, and RORB; but none of these SNPs persisted significantly after performing Bonferroni correction. Moreover, we identified the effect of GSK3B rs2199503 on high fasting glucose (P = 0.0002). Additionally, we found interactions among the ARNTL rs10832020, GSK3B rs2199503, PER3 rs10746473, RORA rs8034880, and RORB rs972902 SNPs influenced MetS (P < 0.001 ~ P = 0.002). Finally, we investigated the influence of interactions between ARNTL rs10832020, GSK3B rs2199503, PER3 rs10746473, and RORB rs972902 with environmental factors such as alcohol consumption, smoking status, and physical activity on MetS and its individual components (P < 0.001 ~ P = 0.002). Our study indicates that circadian clock genes such as ARNTL, GSK3B, PER3, RORA, and RORB genes may contribute to the risk of MetS independently as well as through gene-gene and gene-environment interactions.
Possible metal-insulator transition at B=0 in two dimensions.

We have studied the zero magnetic field resistivity of unique high- mobility two-dimensional electron system in silicon. At very low electron density (but higher than some sample-dependent critical value, $n_{cr}\sim 10^{11}$ cm$^{-2}$), CONVENTIONAL WEAK LOCALIZATION IS OVERPOWERED BY A SHARP DROP OF RESISTIVITY BY AN ORDER OF MAGNITUDE with decreasing temperature below 1--2 K. No further evidence for electron localization is seen down to at least 20 mK. For $n_s<N_{cr}$, the sample is insulating. The resistivity is empirically found to SCALE WITH TEMPERATURE BOTH BELOW AND ABOVE $n_{cr}$ WITH A SINGLE PARAMETER which approaches zero at $n_s=n_{cr}$ suggesting a metal/ insulator phase transition.
MODE, MEANING, AND SYNAESTHESIA IN MULTIMEDIA L2 WRITING

This study of digital storytelling attempts to apply Kress's (2003) notions of synaesthesia, transformation, and transduction to the analysis of four undergraduate L2 writers' multimedia text creation processes. The students, entering freshmen, participated in an experimental course entitled "Multimedia Writing," whose purpose was to experience and explore the processes of multimodal textual communication. With the support of empirical data drawn from interviews, student journals, and the digital story-related artifacts themselves, the author shows how synaesthetically derived meaning may be a natural part of the process of creating multimodal texts. Considering the special case of non-native English speakers, the paper also demonstrates that synaesthesia may have both amplifying and limiting effects on the projection of authorial intention and voice. Before reading the following, it is suggested that the reader view examples of the multimedia essays discussed herein. [Please see accompanying media files].
Culturally antagonistic memes and the Zika virus: an experimental test

This paper examines a remedy for a defect in existing accounts of public risk perceptions. The accounts in question feature two dynamics: the affect heuristic, which emphasizes the impact of visceral feelings on information processing; and the cultural cognition thesis, which describes the tendency of individuals to form beliefs that reflect and reinforce their group commitments. The defect is the failure of these two dynamics, when combined, to explain the peculiar selectivity of public risk controversies: despite their intensity and disruptiveness, such controversies occur less frequently than the affect heuristic and the cultural cognition thesis seem to predict. To account for this aspect of public risk perceptions, the paper describes a model that adds the phenomenon of culturally antagonistic memes – argumentative tropes that fuse positions on risk with contested visions of the best life. Arising adventitiously, antagonistic memes transform affect and cultural cognition from consensus-generating, truth-convergent influences on information processing into conflictual, identity-protective ones. The paper supports this model with experimental results involving perceptions of the risk of the Zika virus: a general sample of US subjects, whose cultural orientations were measured with the Cultural Cognition Worldview Scales, formed polarized affective reactions when exposed to information that was pervaded with antagonistic memes linking Zika to global warming; when exposed to comparable information linking Zika to unlawful immigration, the opposing affective stances of the subjects flipped in direction. Normative and prescriptive implications of these results are discussed.
Academic buoyancy mediates academic anxiety’s effects on learning strategies: an investigation of English- and Chinese-speaking Australian students

Abstract A primary goal our study was to explore whether relations between academic anxiety and students’ use of a range of learning strategies (memorisation, elaboration, personal best [PB] goals and cooperation) were mediated by academic buoyancy. We were also interested in extending knowledge of anxiety and its role in students’ learning strategy use. Given mixed findings regarding the impact of language spoken at home on psycho-educational factors, our third aim involved investigating the extent to which relationships were moderated by language (English vs. Chinese-speaking). The sample consisted of n = 380 English-speaking and Chinese-speaking (Mandarin and Cantonese) Australian high school students, with groups (n = 190 each) matched on age and gender, and controlling for parental education and prior academic achievement. We found mediation effects of academic buoyancy across the four learning strategies. In addition, anxiety was positively associated with memorisation, elaboration and PB goals in the mediation analyses. Mediation effects were broadly similar across the two languages; however, there were some significant differences across the two groups. Findings hold relevance for future research on academic buoyancy’s nomological network, the role of language spoken at home in the academic process and the design of interventions addressing academic buoyancy and academic anxiety.
Self-determination theory applied to flow in conservatoire music practice: The roles of perceived autonomy and competence, and autonomous and controlled motivation

Self-determination theory (SDT) postulates that environments providing psychological needs satisfaction (PNS) promote quality motivation, thus enhancing engagement and performance in diverse performance domains. SDT and PNS were used to investigate student experience of conservatoire instrument practice. Participants (N = 162) completed standardized self-report questionnaires. Associations between study variables were described and hierarchical multiple regression analysis was conducted to assess the predictive effects of autonomy and competence needs satisfaction and autonomous and controlled motivation on inter-subject flow variations. A considerable part of flow variations was accounted for by study variables. Results showed that conservatoire students, especially those studying instrument performance (n = 109), reported high levels of flow, perceived competence and autonomy, and intrinsic motivation. Autonomous motivation had a direct effect on flow variations, whereas controlled motivation had an inverse effect. Perceived competence was the strongest predictor of flow variations and it was also associated with external regulation (especially among students studying instrument performance), thus indicating that intrinsic and extrinsic motives both play important roles in conservatoire instrument practice. Conservatoire instrument teachers need to acknowledge that perceived competence is critical to flow in instrument practice, in order to provide their students with optimal challenges that avoid frustration and amotivation.
Inducing gene expression in barrel cortex--focus on immediate early genes.

Using only their vibrissae, rats and mice are able to recognize and differentiate surfaces not distinguishable by primates using their fingertips. It has been shown that sensory stimulation elicits the expression of immediate-early genes (IEG), e.g., c-fos and zif268, in the sensory cortex of rats and mice. Though most of these findings come from visual system, mice and rats rely more on their vibrissal system which also offers many advantages for designing precise and precisely controlled experiments. In this review, new models for the selective and simple stimulation of vibrissae are presented and discussed. The data demonstrating IEG expression in the vibrissal system is also reviewed.
Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure

ABSTRACT An essential step in muscle fiber maturation is the assembly of highly ordered myofibrils that are required for contraction. Much remains unknown about the molecular mechanisms governing the formation of the contractile apparatus. We identified an early embryonic motility mutant in zebrafish caused by integration of a transgene into the pseudophosphatase dual specificity phosphatase 27 (dusp27) gene. dusp27 mutants exhibit near complete paralysis at embryonic and larval stages, producing extremely low levels of spontaneous coiling movements and a greatly diminished touch response. Loss of dusp27 does not prevent somitogenesis but results in severe disorganization of the contractile apparatus in muscle fibers. Sarcomeric structures in mutants are almost entirely absent and only rare triads are observed. These findings are the first to implicate a functional role of dusp27 as a gene required for myofiber maturation and provide an animal model for analyzing the mechanisms governing myofibril assembly.
Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin‐3/RXFP3 system in neuropsychiatric disorders

Relaxin‐3 has been proposed to modulate emotional–behavioural functions such as arousal and behavioural activation, appetite regulation, stress responses, anxiety, memory, sleep and circadian rhythm. The nucleus incertus (NI), in the midline tegmentum close to the fourth ventricle, projects widely throughout the brain and is the primary site of relaxin‐3 neurons. Over recent years, a number of preclinical studies have explored the function of the NI and relaxin‐3 signalling, including reports of mRNA or peptide expression changes in the NI in response to behavioural or pharmacological manipulations, effects of lesions or electrical or pharmacological manipulations of the NI, effects of central microinfusions of relaxin‐3 or related agonist or antagonist ligands on physiology and behaviour, and the impact of relaxin‐3 gene deletion or knockdown. Although these individual studies reveal facets of the likely functional relevance of the NI and relaxin‐3 systems for human physiology and behaviour, the differences observed in responses between species (e.g. rat vs. mouse), the clearly identified heterogeneity of NI neurons and procedural differences between laboratories are some of the factors that have prevented a precise understanding of their function. This review aims to draw attention to the current preclinical evidence available that suggests the relevance of the NI/relaxin‐3 system to the pathology and/or symptoms of certain neuropsychiatric disorders and to provide cognizant directions for future research to effectively and efficiently uncover its therapeutic potential.
Voice training and therapy with a semi-occluded vocal tract: rationale and scientific underpinnings.

PURPOSE Voice therapy with a semi-occluded vocal tract has a long history. The use of lip trills, tongue trills, bilabial fricatives, humming, and phonation into tubes or straws has been hailed by clinicians, singing teachers, and voice coaches as efficacious for training and rehabilitation. Little has been done, however, to provide the scientific underpinnings. The purpose of the study was to investigate the underlying physical principles behind the training and therapy approaches that use semi-occluded vocal tract shapes. METHOD Computer simulation, with a self-oscillating vocal fold model and a 44 section vocal tract, was used to elucidate source-filter interactions for lip and epilarynx tube semi-occlusions. RESULTS A semi-occlusion in the front of the vocal tract (at the lips) heightens source-tract interaction by raising the mean supraglottal and intraglottal pressures. Impedance matching by vocal fold adduction and epilarynx tube narrowing can then make the voice more efficient and more economic (in terms of tissue collision). CONCLUSION The efficacious effects of a lip semi-occlusion can also be realized for nonoccluded vocal tracts by a combination of vocal fold adduction and epilarynx tube adjustments. It is reasoned that therapy approaches are designed to match the glottal impedance to the input impedance of the vocal tract.
Very high-speed carry computation based on mixed dynamic/transmission-gate Full Adders

In this paper, a circuit design approach to perform very fast carry computation in cascaded Full Adders is proposed. The strategy is based on the adoption of mixed dynamic and transmission-gate Full Adder topologies, as opposite to the traditional approach based on cascaded Full Adders based on the same logic style. Analysis shows that the insertion of transmission-gate Full Adders between dynamic Full Adders does not violate the timing constraints that are required by the latter ones to achieve a correct operation. To evaluate the achievable performance, the proposed approach is compared with traditional domino Full Adder chains. Post- layout simulations on a 90-nm CMOS technology show that the proposed approach outperform the domino speed performance by more than 30%, without degrading the energy efficiency and with no area penalty.
Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase ε

To better understand the functions and fidelity of DNA polymerase ε (Pol ε), we report here on the fidelity of yeast Pol ε mutants with leucine, tryptophan or phenylalanine replacing Met644. The Met644 side chain interacts with an invariant tyrosine that contacts the sugar of the incoming dNTP. M644W and M644L Pol ε synthesize DNA with high fidelity, but M644F Pol ε has reduced fidelity resulting from strongly increased misinsertion rates. When Msh6-dependent repair of replication errors is defective, the mutation rate of a pol2-M644F strain is 16-fold higher than that of a strain with wild-type Pol ε. In conjunction with earlier studies of low-fidelity mutants with replacements for the homologous amino acid in yeast Pol α (L868M/F) and Pol δ (L612M), these data indicate that the active site location occupied by Met644 in Pol ε is a key determinant of replication fidelity by all three B family replicative polymerases. Interestingly, error specificity of M644F Pol ε is distinct from that of L868M/F Pol α or L612M Pol δ, implying that each polymerase has different active site geometry, and suggesting that these polymerase alleles may generate distinctive mutational signatures for probing functions in vivo.
Prefrontal cortical organization of executive function in depression and comorbid anxiety

Cognitive deficits are a prominent source of distress and functional impairment in both depression and anxiety, yet our understanding of these deficits and their mechanisms are limited. These cognitive deficits could be accounted for by fundamental deficit(s) in specific aspects of executive function (EF). Research on the structure of executive dysfunction in depression and anxiety has the potential to provide a mechanistic account of maladaptive patterns of behavior. Item-level exploratory and confirmatory factor analyses were conducted on an ecologicallysensitive measure of EF. Consistent with Miyake et al. (2001), a three-factor model of EF including updating, shifting, and inhibition best fit the data. Structural equation modeling examined the relationship of EF factors to dimensions of psychopathology (anxious apprehension, anxious arousal, anhedonic depression). All three dimensions of psychopathology predicted shifting impairment, with anxious apprehension exhibiting the strongest relationship. Additionally, anxious arousal and anhedonic depression were associated with deficits in updating and inhibition, with anxious arousal exhibiting the stronger relationship in both domains. Implications for the development and maintenance of psychopathology are discussed, including proposed mechanisms of emotion regulation.
Errors in administration of parenteral drugs in intensive care units: multinational prospective study

Objective To assess on a multinational level the frequency, characteristics, contributing factors, and preventive measures of administration errors in parenteral medication in intensive care units. Design Observational, prospective, 24 hour cross sectional study with self reporting by staff. Setting 113 intensive care units in 27 countries. Participants 1328 adults in intensive care. Main outcome measures Number of errors; impact of errors; distribution of error characteristics; distribution of contributing and preventive factors. Results 861 errors affecting 441 patients were reported: 74.5 (95% confidence interval 69.5 to 79.4) events per 100 patient days. Three quarters of the errors were classified as errors of omission. Twelve patients (0.9% of the study population) experienced permanent harm or died because of medication errors at the administration stage. In a multiple logistic regression with patients as the unit of analysis, odds ratios for the occurrence of at least one parenteral medication error were raised for number of organ failures (odds ratio per increase of one organ failure: 1.19, 95% confidence interval 1.05 to 1.34); use of any intravenous medication (yes v no: 2.73, 1.39 to 5.36); number of parenteral administrations (per increase of one parenteral administration: 1.06, 1.04 to 1.08); typical interventions in patients in intensive care (yes v no: 1.50, 1.14 to 1.96); larger intensive care unit (per increase of one bed: 1.01, 1.00 to 1.02); number of patients per nurse (per increase of one patient: 1.30, 1.03 to 1.64); and occupancy rate (per 10% increase: 1.03, 1.00 to 1.05). Odds ratios for the occurrence of parenteral medication errors were decreased for presence of basic monitoring (yes v no: 0.19, 0.07 to 0.49); an existing critical incident reporting system (yes v no: 0.69, 0.53 to 0.90); an established routine of checks at nurses’ shift change (yes v no: 0.68, 0.52 to 0.90); and an increased ratio of patient turnover to the size of the unit (per increase of one patient: 0.73, 0.57 to 0.93). Conclusions Parenteral medication errors at the administration stage are common and a serious safety problem in intensive care units. With the increasing complexity of care in critically ill patients, organisational factors such as error reporting systems and routine checks can reduce the risk for such errors.
Recording of the evoked potentials during functional MRI: Applications in cognitive neuroscience

The feasibility of recording event-related potentials (ERP) during functional MRI (fMRI) scanning using higher-level cognitive stimuli was studied. Using responses to illusory figures in a visual oddball task, evoked potentials were obtained with their expected configuration and latencies. A rapid stimulation scheme using randomly varied trial lengths was employed, and class-wise characteristics of the hemodynamic response were obtained by a non-linear analysis of the fMRI time-series. Implications and limitations of conducting combined ERP-fMRI experiments using higher-level cognitive stimuli are discussed.
X-Ray Emission from Hot Gas in Galaxy Mergers

We examine X-ray emission produced from hot gas during collisions and mergers of disk galaxies. To study this process, we employ simulations that incorporate cosmologically motivated disk-galaxy models and include the effects of radiative cooling, star formation, supernova feedback, and accreting supermassive black holes. We find that during a merger, the colliding gas in the disks is shock heated to X-ray-emitting temperatures. The X-ray luminosity is spatially extended, rises during the initial stages of the merger, and peaks when the galactic centers coalesce. When a physical model for accreting black holes is included, the resulting feedback can drive powerful winds that contribute significantly to the amount and metallicity of hot gas, both of which increase the X-ray luminosity. In terms of their stellar kinematics and structural properties, the merger remnants in our simulations resemble elliptical galaxies. We find that the X-ray luminosities of the remnants with B-band luminosities in the range LB ~ 1010-1011 L☉ are consistent with observations, while remnants with smaller or larger masses are underluminous in X-rays. Moreover, because the majority of the merger remnants are broadly consistent with the observed scaling relations between temperature, B-band luminosity, and X-ray luminosity, we conclude that major mergers are a viable mechanism for producing the X-ray halos of large, luminous elliptical galaxies.