Miracle-dz/UniFAR-FTUs huggingface dataset:
Introgressive hybridization in a Spiny-Tailed Iguana, Ctenosaura pectinata, and its implications for taxonomy and conservation

Introgression, the transmission of genetic material of one taxon into another through hybridization, can have various evolutionary outcomes. Previous studies have detected signs of introgression between western populations of the Mexican endemic and threatened spiny-tailed iguana, Ctenosaura pectinata. However, the extent of this phenomenon along the geographic distribution of the species is unknown. Here, we use multilocus data together with detailed geographic sampling to (1) define genotypic clusters within C. pectinata; (2) evaluate geographic concordance between maternally and biparentally inherited markers; (3) examine levels of introgression between genotypic clusters, and (4) suggest taxonomic modifications in light of this information. Applying clustering methods to genotypes of 341 individuals from 49 localities of C. pectinata and the closely related C. acanthura, we inferred the existence of five genotypic clusters. Contact zones between genotypic clusters with signatures of interbreeding were detected, showing different levels of geographic discordance with mtDNA lineages. In northern localities, mtDNA and microsatellites exhibit concordant distributions, supporting the resurrection of C. brachylopha. Similar concordance is observed along the distribution of C. acanthura, confirming its unique taxonomic identity. Genetic and geographic concordance is also observed for populations within southwestern Mexico, where the recognition of a new species awaits in depth taxonomic revision. In contrast, in western localities a striking pattern of discordance was detected where up to six mtDNA lineages co-occur with only two genotypic clusters. Given that the type specimen originated from this area, we suggest that individuals from western Mexico keep the name C. pectinata. Our results have profound implications for conservation, management, and forensics of Mexican iguanas.
Extrinsic Auditory Contributions to Food Perception & Consumer Behaviour: an Interdisciplinary Review.

Food product-extrinsic sounds (i.e., those auditory stimuli that are not linked directly to a food or beverage product, or its packaging) have been shown to exert a significant influence over various aspects of food perception and consumer behaviour, often operating outside of conscious awareness. In this review, we summarise the latest evidence concerning the various ways in which what we hear can influence what we taste. According to one line of empirical research, background noise interferes with tasting, due to attentional distraction. A separate body of marketing-relevant research demonstrates that music can be used to bias consumers' food perception, judgments, and purchasing/consumption behaviour in various ways. Some of these effects appear to be driven by the arousal elicited by loud music as well as the entrainment of people's behaviour to the musical beat. However, semantic priming effects linked to the type and style of music are also relevant. Another route by which music influences food perception comes from the observation that our liking/preference for the music that we happen to be listening to carries over to influence our hedonic judgments of what we are tasting. A final route by which hearing influences tasting relates to the emerging field of 'sonic seasoning'. A developing body of research now demonstrates that people often rate tasting experiences differently when listening to soundtracks that have been designed to be (or are chosen because they are) congruent with specific flavour experiences (e.g., when compared to when listening to other soundtracks, or else when tasting in silence). Taken together, such results lead to the growing realization that the crossmodal influences of music and noise on food perception and consumer behaviour may have some important if, as yet, unrecognized implications for public health.
Saliency Inside: Learning Attentive CNNs for Content-Based Image Retrieval

In content-based image retrieval (CBIR), one of the most challenging and ambiguous tasks is to correctly understand the human query intention and measure its semantic relevance with images in the database. Due to the impressive capability of visual saliency in predicting human visual attention that is closely related to the query intention, this paper attempts to explicitly discover the essential effect of visual saliency in CBIR via qualitative and quantitative experiments. Toward this end, we first generate the fixation density maps of images from a widely used CBIR dataset by using an eye-tracking apparatus. These ground-truth saliency maps are then used to measure the influence of visual saliency to the task of CBIR by exploring several probable ways of incorporating such saliency cues into the retrieval process. We find that visual saliency is indeed beneficial to the CBIR task, and the best saliency involving scheme is possibly different for different image retrieval models. Inspired by the findings, this paper presents two-stream attentive convolutional neural networks (CNNs) with saliency embedded inside for CBIR. The proposed network has two streams that simultaneously handle two tasks. The main stream focuses on extracting discriminative visual features that are tightly related to semantic attributes. Meanwhile, the auxiliary stream aims to facilitate the main stream by redirecting the feature extraction to the salient image content that a human may pay attention to. By fusing these two streams into the Main and Auxiliary CNNs (MAC), image similarity can be computed as the human being does by reserving conspicuous content and suppressing irrelevant regions. Extensive experiments show that the proposed model achieves impressive performance in image retrieval on four public datasets.
Null Objects in Korean: Experimental Evidence for the Argument Ellipsis Analysis

Null object (NO) constructions in Korean and Japanese have received different accounts: as (a) argument ellipsis (Oku 1998, S. Kim 1999, Saito 2007, Sakamoto 2015), (b) VP-ellipsis after verb raising (Otani and Whitman 1991, Funakoshi 2016), or (c) instances of base-generated pro (Park 1997, Hoji 1998, 2003). We report results from two experiments supporting the argument ellipsis analysis for Korean. Experiment 1 builds on K. -M. Kim and Han’s (2016) finding of interspeaker variation in whether the pronoun ku can be bound by a quantifier. Results showed that a speaker’s acceptance of quantifier-bound ku positively correlates with acceptance of sloppy readings in NO sentences. We argue that an ellipsis account, in which the NO site contains internal structure hosting the pronoun, accounts for this correlation. Experiment 2, testing the recovery of adverbials in NO sentences, showed that only the object (not the adverb) can be recovered in the NO site, excluding the possibility of VP-ellipsis. Taken together, our findings suggest that NOs result from argument ellipsis in Korean.
Structural Imaging and Parkinson’s Disease: Moving Toward Quantitative Markers of Disease Progression

Parkinson’s disease (PD) is a progressive age-related neurodegenerative disorder. Although the pathological hallmark of PD is dopaminergic cell death in the substantia nigra pars compacta, widespread neurodegenerative changes occur throughout the brain as disease progresses. Postmortem studies, for example, have demonstrated the presence of Lewy pathology, apoptosis, and loss of neurotransmitters and interneurons in both cortical and subcortical regions of PD patients. Many in vivo structural imaging studies have attempted to gauge PD-related pathology, particularly in gray matter, with the hope of identifying an imaging biomarker. Reports of brain atrophy in PD, however, have been inconsistent, most likely due to differences in the studied populations (i.e. different disease stages and/or clinical subtypes), experimental designs (i.e. cross-sectional vs. longitudinal), and image analysis methodologies (i.e. automatic vs. manual segmentation). This review attempts to summarize the current state of gray matter structural imaging research in PD in relationship to disease progression, reconciling some of the differences in reported results, and to identify challenges and future avenues.
L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship.

AIMS Administration of L-arginine by intravenous infusion or via oral absorption has been shown to induce peripheral vasodilation in humans, and to improve endothelium-dependent vasodilation. We investigated the pharmacokinetics and pharmacokinetic-pharmacodynamic relationship of L-arginine after a single intravenous infusion of 30 g or 6 g, or after a single oral application of 6 g, as compared with the respective placebo, in eight healthy male human subjects. METHODS L-arginine levels were determined by h.p.l.c. The vasodilator effects of L-arginine were assessed non-invasively by blood pressure monitoring and impedance cardiography. Urinary nitrate and cyclic GMP excretion rates were measured as non-invasive indicators of endogenous NO production. RESULTS Plasma L-arginine levels increased to (mean +/- s.e.mean) 6223+/-407 (range, 5100-7680) and 822+/-59 (527-955) micromol l(-1) after intravenous infusion of 30 g and 6 g L-arginine, respectively, and to 310+/-152 (118-1219) micromol l(-1) after oral ingestion of 6 g L-arginine. Oral bioavailability of L-arginine was 68+/-9 (51-87)%. Clearance was 544+/-24 (440-620), 894+/-164 (470-1190), and 1018+/-230 (710-2130) ml min(-1), and elimination half-life was calculated as 41.6+/-2.3 (34-55), 59.6+/-9.1 (24-98), and 79.5+/-9.3 (50-121) min, respectively, for 30 g i.v. , 6 g i.v. , and 6 g p.o. of L-arginine. Blood pressure and total peripheral resistance were significantly decreased after intravenous infusion of 30 g L-arginine by 4.4+/-1.4% and 10.4+/-3.6%, respectively, but were not significantly changed after oral or intravenous administration of 6 g L-arginine. L-arginine (30 g) also significantly increased urinary nitrate and cyclic GMP excretion rates by 97+/-28 and 66+/-20%, respectively. After infusion of 6 g L-arginine, urinary nitrate excretion also significantly increased, (nitrate by 47+/-12% [P<0.05], cyclic GMP by 67+/-47% [P= ns]), although to a lesser and more variable extent than after 30 g of L-arginine. The onset and the duration of the vasodilator effect of L-arginine and its effects on endogenous NO production closely corresponded to the plasma concentration half-life of L-arginine, as indicated by an equilibration half-life of 6+/-2 (3.7-8.4) min between plasma concentration and effect in pharmacokinetic-pharmacodynamic analysis, and the lack of hysteresis in the plasma concentration-versus-effect plot. CONCLUSIONS The vascular effects of L-arginine are closely correlated with its plasma concentrations. These data may provide a basis for the utilization of L-arginine in cardiovascular diseases.
Fermentation of pseudocereals quinoa, canihua, and amaranth to improve mineral accessibility through degradation of phytate

Abstract BACKGROUND Pseudocereals are nutrient‐rich grains with high mineral content but also phytate content. Phytate is a mineral absorption inhibitor. The study's aim was to evaluate phytate degradation during spontaneous fermentation and during Lactobacillus plantarum 299v® fermentation of quinoa, canihua, and amaranth grains and flours. It also aimed to evaluate the accessibility of iron, zinc, and calcium and to estimate their bioavailability before and after the fermentation of flours with starter culture. Lactic acid, pH, phytate, and mineral content were analyzed during fermentation. RESULTS Higher phytate degradation was found during the fermentation of flours (64–93%) than during that of grains (12–51%). Results suggest that phytate degradation was mainly due to endogenous phytase activity in different pseudocereals rather than the phytase produced by added microorganisms. The addition of Lactobacillus plantarum 299v® resulted in a higher level of lactic acid (76.8–82.4 g kg−1 DM) during fermentation, and a relatively quicker reduction in pH to 4 than in spontaneous fermentation. Mineral accessibility was increased (1.7–4.6‐fold) and phytate : mineral molar ratios were reduced (1.5–4.2‐fold) in agreement with phytate degradation (1.8–4.2‐fold) in fermented flours. The reduced molar ratios were still above the threshold value for the improved estimated mineral bioavailability of mainly iron. CONCLUSION Fermentation proved to be effective for degrading phytate in pseudocereal flours, but less so in grains. Fermentation with Lactobacillus plantarum 299v® improved mineral accessibility and estimated bioavailability in flours. © 2019 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Automatically Evolving Rotation-Invariant Texture Image Descriptors by Genetic Programming

In computer vision, training a model that performs classification effectively is highly dependent on the extracted features, and the number of training instances. Conventionally, feature detection and extraction are performed by a domain expert who, in many cases, is expensive to employ and hard to find. Therefore, image descriptors have emerged to automate these tasks. However, designing an image descriptor still requires domain-expert intervention. Moreover, the majority of machine learning algorithms require a large number of training examples to perform well. However, labeled data is not always available or easy to acquire, and dealing with a large dataset can dramatically slow down the training process. In this paper, we propose a novel genetic programming-based method that automatically synthesises a descriptor using only two training instances per class. The proposed method combines arithmetic operators to evolve a model that takes an image and generates a feature vector. The performance of the proposed method is assessed using six datasets for texture classification with different degrees of rotation and is compared with seven domain-expert designed descriptors. The results show that the proposed method is robust to rotation and has significantly outperformed, or achieved a comparable performance to, the baseline methods.
Comment on “Quantifying long-term scientific impact”

Wang et al. (Reports, 4 October 2013, p. 127) claimed high prediction power for their model of citation dynamics. We replicate their analysis but find discouraging results: 14.75% papers are estimated with unreasonably large μ (>5) and λ (>10) and correspondingly enormous prediction errors. The prediction power is even worse than simply using short-term citations to approximate long-term citations.
Endovascular Treatment of Traumatic Injuries of the Vertebral Artery

BACKGROUND AND PURPOSE: There are a few reports regarding the treatment of traumatic vertebral arteriovenous fistulas and pseudoaneurysms. Our aim was to describe the clinical and angiographic results of endovascular therapy for traumatic injuries of the vertebral artery. MATERIALS AND METHODS: The clinical and angiographic features of 18 traumatic injuries of the vertebral artery during an 8-year period were reviewed. There were 14 male (78%) and 4 female patients (22%). The average age was 28 years (range, 11–49 years). Of the 18 lesions of the vertebral artery, 17 (95%) were the result of penetrating trauma (gunshot or stab wound injury) and 1 (5%) was iatrogenic (jugular vein catheter). In 16 (89%) instances, the injury resulted in an arteriovenous fistula, and in the other 2 (11%), in a pseudoaneurysm. All patients were treated with an endovascular approach by using different techniques (balloon occlusion, coil embolization, and/or stent deployment). RESULTS: Endovascular therapy resulted in immediate lesion total occlusion in 16 (89%) patients. Delayed total occlusion was demonstrated angiographically during follow-up in the 2 remaining patients. Clinical improvement was documented in all patients, and there were no clinically symptomatic complications. CONCLUSION: In this small series, endovascular techniques were a safe and effective method of treatment and were not associated with significant morbidity or mortality.
A Study of Sorting Algorithms on Approximate Memory

Hardware evolution has been one of the driving factors for the redesign of database systems. Recently, approximate storage emerges in the area of computer architecture. It trades off precision for better performance and/or energy consumption. Previous studies have demonstrated the benefits of approximate storage for applications that are tolerant to imprecision such as image processing. However, it is still an open question whether and how approximate storage can be used for applications that do not expose such intrinsic tolerance. In this paper, we study one of the most basic operations in database--sorting on a hybrid storage system with both precise storage and approximate storage. Particularly, we start with a study of three common sorting algorithms on approximate storage. Experimental results show that a 95% sorted sequence can be obtained with up to 40% reduction in total write latencies. Thus, we propose an approx-refine execution mechanism to improve the performance of sorting algorithms on the hybrid storage system to produce precise results. Our optimization gains the performance benefits by offloading the sorting operation to approximate storage, followed by an efficient refinement to resolve the unsortedness on the output of the approximate storage. Our experiments show that our approx-refine can reduce the total memory access time by up to 11%. These studies shed light on the potential of approximate hardware for improving the performance of applications that require precise results.
An Integrated Analysis of Technology Acceptance Behaviour Models: Comparison of Three Major Models

With the development of technology, the company begins to introduce various kinds of technological equipment. Hence, technology acceptance behaviours have become a famous issue. Researchers also construct many technology acceptance behaviour models. Among them a series models in which extended from Theory of Reasoned Action are the most complete. There are also other models construct from different theories, such as Innovation Diffusion Theory, Social Cognitive Theory, and Motivation Theory. However, various models make researchers more difficult to choose and construct a research model. Therefore, this study selects 3 most representative models which include Technology Acceptance Model, Combined Theory of Planned Behaviour and Technology Acceptance Model, and Unified Theory of Acceptance and Use of Technology. Comparing 3 models' richness and parsimony can help to identify their characteristics. According to the research results, the complex models do not necessarily have better explanation ability. On the contrary, the Technology Acceptance Model concurrently has advantage of richness and parsimony.
Impact of aging on adenosine levels, A1/A2 responses, arrhythmogenesis, and energy metabolism in rat heart.

Adenosine formation, energy metabolism, A1 and A2 responses, and arrhythmogenesis were examined in hearts from young adult (4-6 mo) and aged rats (18-20 mo). Aging reduced heart rate from 308 +/- 9 to 252 +/- 13 beats/min and myocardial O2 consumption (MVO2) from 127 +/- 5 to 103 +/- 4 microliters O2.min-1.g-1 and increased atrioventricular conduction time from 47 +/- 4 to 61 +/- 8 ms. Differences in intrinsic rate were reduced by A1 antagonism with 10 microM 8-cyclopentyl-1,3-dimethylxanthine. Adenosine efflux and cardiac microdialysate [adenosine] in isovolumically working hearts increased twofold with aging, despite reduced MVO2. Enhanced [adenosine] was not due to altered uptake and catabolism but was associated with twofold higher cytosolic adenosine 5'-monophosphate concentration despite comparable energy state (free energy of ATP hydrolysis = -62.25 +/- 0.38 and -61.78 +/- 0.46 kJ/mol in young adult and aged hearts, respectively). Bradycardia (presumably A1 mediated) was 10-fold more sensitive in aged [-log dose required to produce 50% ectopy (pEC50) = 4.9 +/- 0.1] than in young adult hearts (pEC50 = 3.9 +/- 0.1). Adenosine also became potently arrhythmogenic with aging (-log dose required to produce 20% ectopy = 3.6 +/- 0.3 in young adult and 5.3 +/- 0.2 and aged hearts). Alternatively, vasodilation (presumably A2 mediated) was less sensitive with aging (pEC50 = 6.1 +/- 0.1 in young adult and 4.5 +/- 0.1 in aged hearts; pEC50 = 3.8 +/- 0.1 in young adult and 3.1 +/- 0.1 in aged aortic rings). The data indicate that aging 1) enhances interstitial [adenosine], probably via elevated myocardial adenosine 5'-monophosphate concentration, 2) enhances A1 sensitivity and arrhythmogenesis, and 3) reduces adenosine A2 sensitivity. These changes contribute to altered cardiovascular function in aged hearts.
North American Climate in CMIP5 Experiments: Part III: Assessment of Twenty-First-Century Projections*

AbstractIn part III of a three-part study on North American climate in phase 5 of the Coupled Model Intercomparison Project (CMIP5) models, the authors examine projections of twenty-first-century climate in the representative concentration pathway 8.5 (RCP8.5) emission experiments. This paper summarizes and synthesizes results from several coordinated studies by the authors. Aspects of North American climate change that are examined include changes in continental-scale temperature and the hydrologic cycle, extremes events, and storm tracks, as well as regional manifestations of these climate variables. The authors also examine changes in the eastern North Pacific and North Atlantic tropical cyclone activity and North American intraseasonal to decadal variability, including changes in teleconnections to other regions of the globe. Projected changes are generally consistent with those previously published for CMIP3, although CMIP5 model projections differ importantly from those of CMIP3 in some aspects, inc.
Cardiovascular Complications of Sleep Apnea: Role of Oxidative Stress

Obstructive sleep apnea (OSA) occurs in 2% of middle-aged women and 4% of middle-aged men with a higher prevalence among obese subjects. This condition is considered as an independent risk factor for cerebrovascular and cardiovascular diseases. One of the major pathophysiological characteristics of OSA is intermittent hypoxia. Hypoxia can lead to oxidative stress and overproduction of reactive oxygen species, which can lead to endothelial dysfunction, a hallmark of atherosclerosis. Many animal models, such as the rodent model of intermittent hypoxia, mimic obstructive sleep apnea in human patients and allow more in-depth investigation of biological and cellular mechanisms of this condition. This review discusses the role of oxidative stress in cardiovascular disease resulting from OSA in humans and animal models.