Miracle-dz/UniFAR-FTUs huggingface dataset:
Changes in weight and weight distribution across the lifespan among HIV-infected and -uninfected men and women

AbstractExamine body composition changes across the lifespan of HIV-infected compared to uninfected adults. Longitudinal study of antiretroviral therapy (ART)-treated HIV-infected and uninfected participants from the Multicenter AIDS Cohort Study and Women's Interagency HIV Study. Body mass index (BMI), waist (WC), hip circumference (HC), and waist-to-height ratio (WHtR) measured at semiannual visits from 1999 to 2014. The age effect on outcomes over time was investigated using multivariate, piecewise, linear mixed-effect regression models adjusted for demographics, substance use, and comorbidities. Person-visits from 2363 men (1059 HIV-infected/1304 HIV-uninfected) and 2200 women (1455 HIV-infected/745 HIV-uninfected), median ages 45 [IQR 39,51] and 40 [32,46], respectively, were included. BMI gains were slower among HIV-infected participants of 40 years or less (P < 0.001), similar between HIV-infected and uninfected persons 40 to 60 years of age, and plateaued after age 60 in both groups. WC and WHtR increased across the age spectrum (P < 0.001) regardless of HIV serostatus, with significantly greater gains in HIV-infected men more than 60. Black race and Hispanic ethnicity were associated with greater BMI and WC. Lower BMI, WC, hip circumference, and WHtR were associated with hepatitis C infection among women only, and with substance use among all participants, and with lower CD4+ cell count and shorter ART duration among HIV-infected participants. Slower BMI gain among younger HIV-infected adults may be partly explained by substance use and hepatitis C infection, and suggests that lower BMI does not represent improved health. Further analysis of muscle and fat abundance and quality will advance understanding of metabolic risk over the lifespan, a key to reducing morbidity in an aging population.
Regular breakfast consumption is associated with higher blood vitamin status in adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study

Abstract Objective The present study aimed to examine the association between different breakfast consumption patterns and vitamin intakes and blood vitamin concentrations in European adolescents. Design Breakfast consumption was assessed by a questionnaire. Vitamin intake was calculated from two 24 h recalls. Blood vitamin and total homocysteine (tHcy) concentrations were analysed from fasting blood samples. Setting The European Commission-funded HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. Subjects Participants were 1058 (52·8 % females) European adolescents (aged 12·5–17·5 years) from ten cities. Results Lower vitamin D and vitamin C concentrations were observed in male and female breakfast skippers than in consumers (P<0·05). Female breakfast consumers presented higher holo-transcobalamin and lower tHcy (P<0·05), while males had higher cobalamin concentrations, compared with skippers (P<0·05). Higher vitamin D and total folate intakes were observed in adolescents who consumed breakfast compared with skippers (P<0·05). Likewise, female consumers had higher intakes of vitamin B6 and vitamin E than occasional consumers (P<0·05). Conclusions Regular breakfast consumption is associated with higher blood vitamin D and cobalamin concentrations in males and with higher vitamin D and holo-transcobalamin and lower tHcy concentrations in females. Moreover, breakfast consumption is associated with high intakes of vitamin D and total folate in both sexes, and with high intakes of vitamin B6 and vitamin E in females.
Removal of Chromium from Industrial Wastewater

chromium is a pollutant found in surface and underground waters that causes serious environmental hazards. Chromium enters water as a result of industrial activities such as electroplating, dyeing, leather tanning, and metal manufacturing. The objective of the present laboratory-experimental study was to remove chromate from industrial effluents using silicon nanoparticles. The experiments were performed with both simulated synthetic wastewater and true wastewater. Various parameters such as pH, contact time, and different concentrations of Cr(VI) and SiO2 were examined. The data obtained were analyzed using the Excel and SPSS Ver. 16. It was found that Cr(VI) removal increased with decreasing pH and increasing contact time. The highest Cr(VI) removal was achieved at pH=3 and a contact time of 120 minutes. It was also observed that removal
Size distribution and scattering phase function of aerosol particles retrieved from sky brightness measurements

Ground-based measurements of the solar transmission and sky radiance in a horizontal plane through the Sun are taken in several geographical regions and aerosol types: dust in a desert transition zone in Israel, sulfate particles in Eastern and Western Europe, tropical aerosol in Brazil, and mixed continental/maritime aerosol in California. Stratospheric aerosol was introduced after the eruption of Mount Pinatubo in June 1991. Therefore measurements taken before the eruption are used to analyze the properties of tropospheric aerosol; measurements from 1992 are also used to detect the particle size and concentration of stratospheric aerosol. The measurements are used to retrieve the size distribution and the scattering phase function at large scattering angles of the undisturbed aerosol particles. The retrieved properties represent an average on the entire atmospheric column. A comparison between the retrieved phase function for a scattering angle of 120°, with phase function predicted from the retrieved size distribution, is used to test the assumption of particle homogeneity and sphericity in radiative transfer models (Mie theory). The effect was found to be small (20%±15%). For the stratospheric aerosol (sulfates), as expected, the phase function was very well predicted using the Mie theory. A model with a power law size distribution, based on the spectral dependence of the optical thickness, a, cannot estimate accurately the phase function (up to 50% error for λ = 0.87 μm). Before the Pinatubo eruption the ratio between the volumes of sulfate and coarse particles was very well correlated with α. The Pinatubo stratospheric aerosol destroyed this correlation. The aerosol optical properties are compared with analysis of the size, shape, and composition of the individual particles by electron microscopy of in situ samples. The measured volume size distributions before the injection of stratospheric aerosol consistently show two modes, sulfate particles with rm 0.7 μm. The “window” in the tropospheric aerosol in this radius range was used to observe a stable stratospheric aerosol in 1992, with rm ∼ 0.5 μm. A combination of such optical thickness and sky measurements can be used to assess the direct forcing and the climatic impact of aerosol. Systematic inversion for the key aerosol types (sulfates, smoke, dust, and maritime aerosol) of the size distribution and phase function can give the relationship between the aerosol physical and optical properties that can be used to compute the radiative forcing. This forcing can be validated in dedicated field experiments.
Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Kasabach-Merritt syndrome (KMS) consists of a clinical trial of capillary hemangioma, thrombocytopenia and disseminated intravascular coagulation. KMS occurs most commonly in the pediatric population, and its occurrence in adults is rare. Specific guidelines or randomized clinical trials guiding clinical management of KMS in adult patient are lacking. This manuscript provides a comprehensive review of KMS and discusses recent advances in the medical management of KMS. We also propose a systematic therapeutic approach which would serve as a guide in the management of adult patients with KMS caused by hemangiomas.
Photo-lability of deep ocean dissolved black carbon

Abstract. Dissolved black carbon (DBC), defined here as condensed aromatics isolated from seawater via PPL solid phase extraction and quantified as benzenepolycarboxylic acid (BPCA) oxidation products, is a significant component of the oceanic dissolved organic carbon (DOC) pool. These condensed aromatics are widely distributed in the open ocean and appear to be tens of thousands of years old. As such DBC is regarded as highly refractory. In the current study, the photo-lability of DBC, DOC and coloured dissolved organic matter (CDOM; ultraviolet-visible absorbance) were determined over the course of a 28 day irradiation of North Atlantic Deep Water under a solar simulator. During the irradiation DBC fell from 1044 ± 164 nM-C to 55 ± 15 nM-C, a 20-fold decrease in concentration. Dissolved black carbon photo-degradation was more rapid and more extensive than for bulk CDOM and DOC. The concentration of DBC correlated with CDOM absorbance and the quality of DBC indicated by the ratios of different BPCAs correlated with CDOM absorbance spectral slope, suggesting the optical properties of CDOM may provide a proxy for both DBC concentrations and quality in natural waters. Further, the photo-lability of components of the DBC pool increased with their degree of aromatic condensation. These trends indicate that a continuum of compounds of varying photo-lability exists within the marine DOC pool. In this continuum, photo-lability scales with aromatic character, specifically the degree of condensation. Scaling the rapid photo-degradation of DBC to rates of DOC photo-mineralisation for the global ocean leads to an estimated photo-chemical half-life for oceanic DBC of less than 800 years. This is more than an order of magnitude shorter than the apparent age of DBC in the ocean. Consequently, photo-degradation is posited as the primary sink for oceanic DBC and the apparent survival of DBC molecules in the oceans for millennia appears to be facilitated not by their inherent inertness but by the rate at which they are cycled through the surface ocean's photic zone.
Extended Kalman Filter Implementation for the Khepera II Mobile Robot

The accurate estimation of robot position and orientation in real-time is one of the fundamental challenges in mobile robotics. The Extended Kalman Filter is a nonlinear real-time recursive time domain filter that combines available sensor data to produce an accurate estimate of state, and has been successfully applied to the localization problem in mobile robotics and aircraft navigation. This report describes an Extended Kalman Filter implementation for the Khepera II mobile robotics platform that seeks to produce accurate localization estimates in real-time using wheel odometry data, IR sensor range data, and compass heading data.
Computing the jth solution of a first-order query

We design algorithms of “optimal" data complexity for several natural problems about first-order queries on structures of bounded degree. For that purpose, we first introduce a framework to deal with logical or combinatorial problems R ⊂ I x O whose instances x ∈ I may admit of several solutions R(x) = {y ∈ O : (x,y) ∈ R} . One associates to such a problem several specific tasks: compute a random (for the uniform probability distribution) solution y ∈ R(x) ; enumerate without repetition each solution y j in some specific linear order y 0 1 n-1 where R(x) = {y 0 ,. ,y n-1 } ; compute the solution y j of rank j in the linear order . Algorithms of “minimal" data complexity are presented for the following problems: given any first-order formula $\varphi(\bar{v})$ and any structure S of bounded degree: (1) compute a random element of $\varphi(S)=\{\bar{a}: (S,\bar{a})\models\varphi(\bar{v})\}$ ; (2) compute the j th element of $\varphi(S)$ for some linear order of $\varphi(S)$ ; (3) enumerate the elements of $\varphi(S)$ in lexicographical order. More precisely, we prove that, for any fixed formula φ , the above problem (1) (resp. (2) , (3) ) can be computed within average constant time (resp. within constant time, with constant delay) after a linear (O(|S|)) precomputation. Our essential tool for deriving those complexity results is a normalization procedure of first-order formulas on bijective structures .
Group A streptococcal strains isolated in Lao People's Democratic Republic from 2004 to 2013

SUMMARY Epidemiological data regarding group A streptococcal (GAS) infections in South East Asia are scarce with no information from Laos. We characterized emm types, emm clusters and the antibiotic resistance profile of 124 GAS isolates recovered in Laos during 2004–2013. Most strains were recovered from skin and invasive infections (76% and 19%, respectively). Thirty-four emm types were identified as belonging to 12 emm clusters and no novel emm types were identified. No significant differences were observed in the distribution of emm types or emm clusters according to age or site of recovery (skin or invasive infections). There was moderate strain diversity in this country but considerable differences in emm-type distribution between Laos, Thailand and Cambodia. Vaccine coverage was high for the J8 vaccine candidate. The theoretical coverage for the 30-valent vaccine candidate needs further investigation. Antibiotic resistance was moderate to erythromycin and chloramphenicol (8% and 7%, respectively) and low to ofloxacin (<1%).
Increasing Demand for Natural Rubber Necessitates a Robust Sustainability Initiative to Mitigate Impacts on Tropical Biodiversity

Strong international demand for natural rubber is driving expansion of industrial‐scale and smallholder monoculture plantations, with >2 million ha established during the last decade. Mainland Southeast Asia and Southwest China represent the epicenter of rapid rubber expansion; here we review impacts on forest ecosystems and biodiversity. We estimate that 4.3–8.5 million ha of additional rubber plantations are required to meet projected demand by 2024, threatening significant areas of Asian forest, including many protected areas. Uncertainties concern the potential for yield intensification of existing cultivation to mitigate demand for new rubber area, versus potential displacement of rubber by more profitable oil palm. Our review of available studies indicates that conversion of forests or swidden agriculture to monoculture rubber negatively impacts bird, bat and invertebrate biodiversity. However, rubber agroforests in some areas of Southeast Asia support a subset of forest biodiversity in landscapes that retain little natural forest. Work is urgently needed to: improve understanding of whether land‐sparing or land‐sharing rubber cultivation will best serve biodiversity conservation, investigate the potential to accommodate biodiversity within existing rubber‐dominated landscapes while maintaining yields, and ensure rigorous biodiversity and social standards via the development of a sustainability initiative.
Male Mating Competitiveness of a Wolbachia-Introgressed Aedes polynesiensis Strain under Semi-Field Conditions

Background Lymphatic filariasis (LF), a global public health problem affecting approximately 120 million people worldwide, is a leading cause of disability in the developing world including the South Pacific. Despite decades of ongoing mass drug administration (MDA) in the region, some island nations have not yet achieved the threshold levels of microfilaremia established by the World Health Organization for eliminating transmission. Previously, the generation of a novel Aedes polynesiensis strain (CP) infected with an exogenous type of Wolbachia has been described. The CP mosquito is cytoplasmically incompatible (i.e., effectively sterile) when mated with wildtype mosquitoes, and a strategy was proposed for the control of A. polynesiensis populations by repeated, inundative releases of CP males to disrupt fertility of wild females. Such a strategy could lead to suppression of the vector population and subsequently lead to a reduction in the transmission of filarial worms. Methodology/Principal Findings CP males and F1 male offspring from wild-caught A. polynesiensis females exhibit near equal mating competitiveness with F1 females under semi-field conditions. Conclusions/Significance While laboratory experiments are important, prior projects have demonstrated the need for additional testing under semi-field conditions in order to recognize problems before field implementation. The results reported here from semi-field experiments encourage forward progression toward small-scale field releases.
Automatic Building of Java Projects in Software Repositories: A Study on Feasibility and Challenges

Despite the advancement in software build tools such as Maven and Gradle, human involvement is still often required in software building. To enable large-scale advanced program analysis and data mining of software artifacts, software engineering researchers need to have a large corpus of built software, so automatic software building becomes essential to improve research productivity. In this paper, we present a feasibility study on automatic software building. Particularly, we first put state-of-the-art build automation tools (Ant, Maven and Gradle) to the test by automatically executing their respective default build commands on top 200 Java projects from GitHub. Next, we focus on the 86 projects that failed this initial automated build attempt, manually examining and determining correct build sequences to build each of these projects. We present a detailed build failure taxonomy from these build results and show that at least 57% build failures can be automatically resolved.
Microbial Metabolism of Danazol: A Contribution to Doping Analysis

Microbial metabolism of danazol (17α-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17ß-ol) by Beauveria bassiana ATCC 7159 and Glyocladium viride ATCC 10097 afforded four metabolites. The isolated metabolites were identified by different spectroscopic techniques as 6ß- hydroxy danazol, which is a not yet reported danazol metabolite, 17ß-hydroxy-17α-pregn-4-en- 20-yn-3-one (ethisterone) and 17ß-hydroxy-2α-(hydroxymethyl)-17α-pregn-4-en-20-yn-3-one (2α- hydroxymethyl ethisterone), which represent the major danazol metabolites detected in human urine. The last metabolite, 6ß,17ß-dihydroxy-2-(hydroxymethyl)-17α-pregna-1,4-dien-20-yn-3-one, is also a minor human metabolite, for which the NMR data are described here for the first time. The metabolites were isolated in quantities that allowed their use for direct comparison in routine doping analysis
WebVision Database: Visual Learning and Understanding from Web Data

In this paper, we present a study on learning visual recognition models from large scale noisy web data. We build a new database called WebVision, which contains more than $2.4$ million web images crawled from the Internet by using queries generated from the 1,000 semantic concepts of the benchmark ILSVRC 2012 dataset. Meta information along with those web images (e.g., title, description, tags, etc.) are also crawled. A validation set and test set containing human annotated images are also provided to facilitate algorithmic development. Based on our new database, we obtain a few interesting observations: 1) the noisy web images are sufficient for training a good deep CNN model for visual recognition; 2) the model learnt from our WebVision database exhibits comparable or even better generalization ability than the one trained from the ILSVRC 2012 dataset when being transferred to new datasets and tasks; 3) a domain adaptation issue (a.k.a., dataset bias) is observed, which means the dataset can be used as the largest benchmark dataset for visual domain adaptation. Our new WebVision database and relevant studies in this work would benefit the advance of learning state-of-the-art visual models with minimum supervision based on web data.
Ultrasound-targeted transfection of tissue-type plasminogen activator gene carried by albumin nanoparticles to dog myocardium to prevent thrombosis after heart mechanical valve replacement

Background There are more than 300,000 prosthetic heart valve replacements each year worldwide. These patients are faced with a higher risk of thromboembolic events after heart valve surgery and long-term or even life-long anticoagulative and antiplatelet therapies are necessary. Some severe complications such as hemorrhaging or rebound thrombosis can occur when the therapy ceases. Tissue-type plasminogen activator (t-PA) is a thrombolytic agent. One of the best strategies is gene therapy, which offers a local high expression of t-PA over a prolonged time period to avoid both systemic hemorrhaging and local rebound thrombosis. There are some issues with t-PA that need to be addressed: currently, there is no up-to-date report on how the t-PA gene targets the heart in vivo and the gene vector for t-PA needs to be determined. Aims To fabricate an albumin nano-t-PA gene ultrasound-targeted agent and investigate its targeting effect on prevention of thrombosis after heart mechanic valve replacement under therapeutic ultrasound. Methods A dog model of mechanical tricuspid valve replacement was constructed. A highly expressive t-PA gene plasmid was constructed and packaged by nanoparticles prepared with bovine serum albumin. This nanopackaged t-PA gene plasmid was further cross-linked to ultrasonic microbubbles prepared with sucrose and bovine serum albumin to form the ultrasonic-targeted agent for t-PA gene transfection. The agent was given intravenously followed by a therapeutic ultrasound treatment (1 MHz, 1.5 w/cm2, 10 minutes) of the heart soon after valve replacement had been performed. The expression of t-PA in myocardium was detected with multiclonal antibodies to t-PA by the indirect immunohistochemical method. Venous blood t-PA and D-dimer contents were tested before and 1, 2, 4, and 8 weeks after the operation. Results The high expression of t-PA could be seen in myocardium with increases in blood t-PA and D-dimer contents and thrombosis was prevented 8 weeks after operation. Conclusion We successfully fabricated an albumin nano-t-PA gene ultrasound-targeted agent that could prevent dog thrombosis after mechanical heart valve replacement. Our study provides an experimental basis for prevention of human thrombosis-related diseases.
Cognitive ability and risk of post-traumatic stress disorder after military deployment: an observational cohort study

Background Studies of the association between pre-deployment cognitive ability and post-deployment post-traumatic stress disorder (PTSD) have shown mixed results. Aims To study the inflence of pre-deployment cognitive ability on PTSD symptoms 6–8 months post-deployment in a large population while controlling for pre-deployment education and deployment-related variables. Method Study linking prospective pre-deployment conscription board data with post-deployment self-reported data in 9695 Danish Army personnel deployed to different war zones in 1997–2013. The association between pre-deployment cognitive ability and post-deployment PTSD was investigated using repeated-measure logistic regression models. Two models with cognitive ability score as the main exposure variable were created (model 1 and model 2). Model 1 was only adjusted for pre-deployment variables, while model 2 was adjusted for both pre-deployment and deployment-related variables. Results When including only variables recorded pre-deployment (cognitive ability score and educational level) and gender (model 1), all variables predicted post-deployment PTSD. When deployment-related variables were added (model 2), this was no longer the case for cognitive ability score. However, when educational level was removed from the model adjusted for deployment-related variables, the association between cognitive ability and post-deployment PTSD became significant. Conclusions Pre-deployment lower cognitive ability did not predict post-deployment PTSD independently of educational level after adjustment for deployment-related variables.