Miracle-dz/UniFAR-FTUs huggingface dataset:
Interexaminer reliability and clinical validity of the temporomandibular index: a new outcome measure for temporomandibular disorders.

AIMS The operational definitions for the Craniomandibular Index (CMI) were redesigned to conform precisely to those of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), resulting in a single examination protocol, the Temporomandibular Index (TMI). The objectives were to evaluate interexaminer reliability of the TMI as well as its criteria and construct validity for measurement of TMD severity. METHODS Interexaminer reliability of the TMI was assessed on 12 subjects. Criterion validity of the TMI was evaluated relative to the CMI, the latter having established validity. Construct validity of the TMI was evaluated for its capacity to differentiate TMD patients (n = 79) from normal subjects (n = 20) and to detect changes in severity over time. RESULTS The examiner's average TMI scores were 0.27 +/- 0.19 (SD) and 0.26 +/- 0.20. Agreement was excellent, with an intraclass correlation coefficient (ICC) of 0.93. The scores for the TMI and the CMI correlated highly, with an ICC of 0.97. Statistical contrasts between the symptomatic groups and the normal subjects were highly significant (P < .001). In 20 TMD patients who underwent treatment for their disorder, their mean change of 0.12 from their pretreatment TMI scores was highly significant (P < .001). CONCLUSION This study has provided statistical evidence for the clinical reliability and validity of the TMI, which indicates that the RDC examination protocol is appropriate for determining TMD severity by the TMI algorithm, and diagnosis of TMD subtypes by the RDC algorithm.
Angiotensin II-induced inotropism requires an endocardial endothelium-nitric oxide mechanism in the in-vitro heart of Anguilla anguilla

SUMMARY Using an isolated working heart preparation we show that angiotensin II (ANG II), at concentrations of 10-10–10-7 mol l-1, elicits negative chronotropism and inotropism in the freshwater eel Anguilla anguilla. The negative inotropism was insensitive to losartan and CGP42112 (AT1 and AT2 ANG II receptor antagonists, respectively), and was abrogated by the AT1 receptor antagonist CV11974, the G protein blocker pertussis toxin (PTx) and the muscarinic antagonist atropine. In contrast, it was not affected by the adrenoceptor antagonists propanolol, sotalol and phentolamine. Using donors (l-arginine) and inhibitors [NG-monomethyl-L-arginine (l-NMMA), l-N5(1-iminoethyl)ornithine (L-NIO)] of nitric oxide synthase (NOS), and haemoglobin as NO scavenger, we demonstrate that NO signalling is involved in ANG II-mediated inotropism. Pretreatment with Triton X-100, a detergent that damages the endocardial endothelium (EE), or with 1H-(1,2,4)oxadiazolo-(4,3-a)quinoxalin-1-one (ODQ), a specific inhibitor of soluble guanylate cyclase, or with the cGMP-activated protein kinase (PKG) inhibitor KT5328, abolished ANG II-mediated inotropism. Thus, ANG II-mediated inotropism occurs via an EE-NO-cGMP-PKG mechanism. ANG II did not affect the mechanical performance influenced by preload changes (i.e. the Frank–Starling response), which in the eel heart is modulated by NO. This EE-paracrine-mediated cardio-suppressive action of endoluminal ANG II suggests that the hormone plays an important intracardiac role in the fish heart.
Auxin-dependent regulation of lateral root positioning in the basal meristem of Arabidopsis

In plants, the developmental mechanisms that regulate the positioning of lateral organs along the primary root are currently unknown. We present evidence on how lateral root initiation is controlled in a spatiotemporal manner in the model plant Arabidopsis thaliana. First, lateral roots are spaced along the main axis in a regular left-right alternating pattern that correlates with gravity-induced waving and depends on AUX1, an auxin influx carrier essential for gravitropic response. Second, we found evidence that the priming of pericycle cells for lateral root initiation might take place in the basal meristem, correlating with elevated auxin sensitivity in this part of the root. This local auxin responsiveness oscillates with peaks of expression at regular intervals of 15 hours. Each peak in the auxin-reporter maximum correlates with the formation of a consecutive lateral root. Third, auxin signaling in the basal meristem triggers pericycle cells for lateral root initiation prior to the action of INDOLE-3-ACETIC ACID14 (SOLITARY ROOT).
Trade , Human Capital and Innovation : The Engines of European Regional Growth in the 1990 s Table of Contents

This paper investigates the growth factors of EU regions in the 1990s. We test the hypothesis that regional growth is determined by endogenous growth factors, trade and technological catching-up in a growth accounting framework. Our estimations suggest that growth of EU regions is positively related to the accumulation of physical and human capital. Innovation activity as well as international technology transfer are important for growth. The latter is facilitated if a region is well endowed with human capital. Further, we observe that technological catching-up is promoted by intensive foreign trade, a result which underlines the importance of trade openness for EU regions. JEL classification: O300, O400, O520, R110.
Formation of vesicular stomatitis virus nucleocapsid from cytoskeletal framework-bound N protein: possible model for structure assembly

The pathway of vesicular stomatitis virus N protein from synthesis to assembly into capsids was studied by use of detergent extraction of infected HeLa cells together with protein cross-linking. One half of the newly synthesized N protein was extracted with the soluble cell proteins and, when cross-linked, never formed the N-N dimer characteristic of mature nucleocapsids. In contrast, the cytoskeleton-bound N protein first showed a diffuse spectrum of protein-protein cross-links but, after a lag of 40 min, assumed the cross-link pattern of N protein in nucleocapsids. The efficiency of forming N-N cross-linked dimers is the same for N protein on the skeleton as in nucleocapsids derived from mature virus, suggesting very similar configurations. However, the N protein bound on the skeletal framework formed several additional cross-links that were not found in mature virus and were apparently formed to cellular proteins estimated to be ca. approximately 46,000 and 60,000 in molecular weight.
Energy Efficient Downlink Cooperative Transmission With BS and Antenna Switching off

In this paper, we strive to improve the energy efficiency (EE) of downlink base station (BS) cooperative transmission systems by switching off some BSs and antennas and allocating power to the users according to the required data rate and channel of each user. To show the potential of EE gain, we first propose an optimal dynamic switching off scheme using instantaneous channel information that maximizes the EE under per-user data rate and per-BS power constraints. To provide a feasible scheme for practical systems, we proceed to propose a semi-dynamic scheme where the BS-antenna operation pattern selection is based on average channel gains. Low complexity iterative algorithms are provided to find solutions for the dynamic and semi-dynamic strategies. Simulation results with typical circuit power consumption show that the semi-dynamic scheme performs close to the dynamic scheme and both schemes provide a substantial EE gain over the scheme with all antennas at all BSs active, when the data rate requirement is low. By comparing the overall power consumption for the systems of two extreme cases in deploying the active antennas, we find that the scheme only switching off BSs is more cost-effective in terms of energy than the scheme switching off antennas when the data rate requirement is low and the number of active antennas far exceeds that of the users.
Evolution of accelerometer methods for physical activity research

The technology and application of current accelerometer-based devices in physical activity (PA) research allow the capture and storage or transmission of large volumes of raw acceleration signal data. These rich data not only provide opportunities to improve PA characterisation, but also bring logistical and analytic challenges. We discuss how researchers and developers from multiple disciplines are responding to the analytic challenges and how advances in data storage, transmission and big data computing will minimise logistical challenges. These new approaches also bring the need for several paradigm shifts for PA researchers, including a shift from count-based approaches and regression calibrations for PA energy expenditure (PAEE) estimation to activity characterisation and EE estimation based on features extracted from raw acceleration signals. Furthermore, a collaborative approach towards analytic methods is proposed to facilitate PA research, which requires a shift away from multiple independent calibration studies. Finally, we make the case for a distinction between PA represented by accelerometer-based devices and PA assessed by self-report.
A large hierarchical network star - star topology design algorithm

The hierarchical communication network design includes solving problems like the concentrator quantity problem, the concentrator location problem and the assignment problem. Many algorithms have been proposed to solve these particular problems. The two latter problems are NP—hard and no optimal solution of these problems has been found for large networks. In this paper we present a high complexity algorithm for star—star network topology design which solves all three problems for several hierarchy levels simultaneously and finds a superior solution in a reasonable time even for large networks with a few thousand terminals due to a new and quick assignment algorithm. The computational results showed that our assignment algorithm is superior to “Simulated annealing” and “Tabu search”.
Combined Receptor and Ligand-Based Approach to the Universal Pharmacophore Model Development for Studies of Drug Blockade to the hERG1 Pore Domain

Long QT syndrome, LQTS, results in serious cardiovascular disorders, such as tachyarrhythmia and sudden cardiac death. A promiscuous binding of different drugs to the intracavitary binding site in the pore domain (PD) of human ether-a-go-go related gene (hERG) channels leads to a similar dysfunction, known as a drug-induced LQTS. Therefore, an assessment of the blocking ability for potent drugs is of great pragmatic value for molecular pharmacology and medicinal chemistry of hERGs. Thus, we attempted to create an in silico model aimed at blinded drug screening for their blocking ability to the hERG1 PD. Two distinct approaches to the drug blockage, ligand-based QSAR and receptor-based molecular docking methods, are combined for development of a universal pharmacophore model, which provides rapid assessment of drug blocking ability to the hERG1 channel. The best 3D-QSAR model (AAADR.7) from PHASE modeling was selected from a pool consisting of 44 initial candidates. The constructed model using 31 hERG blockers was validated with 9 test set compounds. The resulting model correctly predicted the pIC(50) values of test set compounds as true unknowns. To further evaluate the pharmacophore model, 14 hERG blockers with diverse hERG blocking potencies were selected from literature and they were used as additional external blind test sets. The resulting average deviation between in vitro and predicted pIC(50) values of external test set blockers is found as 0.29 suggesting that the model is able to accuretely predict the pIC(50) values as true unknowns. These pharmacophore models were merged with a previously developed atomistic receptor model for the hERG1 PD and exhibited a high consistency between ligand-based and receptor-based models. Therefore, the developed 3D-QSAR model provides a predictive tool for profiling candidate compounds before their synthesis. This model also indicated the key functional groups determining a high-affinity blockade of the hERG1 channel. To cross-validate consistency between the constructed hERG1 pore domain and the pharmacophore models, we performed docking studies using the homology model of hERG1. To understand how polar or nonpolar moieties of inhibitors stimulate channel inhibition, critical amino acid replacement (i.e., T623, S624, S649, Y652 and F656) at the hERG cavity was examined by in silico mutagenesis. The average docking score differences between wild type and mutated hERG channels was found to have the following order: F656A > Y652A > S624A > T623A > S649A. These results are in agreement with experimental data.
Making Judgments as the Basis for Workplace Learning: Preliminary Research Findings. Working Paper.

'Grant was not a "lawyer's lawyer". He would not want to be remembered for his technical abilities or craftsmanship in the law, although it has to be said that he was a most accomplished lawyer. His talents lay more in his use of masterful judgment and tactics in litigation. He always had an uncanny "feel" for a case.
Clinical Effectiveness of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Management of Renal Cell Carcinoma: A Single Institution Experience

Positron emission tomography (PET) is currently the most advanced technique of metabolic imaging available for tumor diagnosis and follow-up. The aim of this study was to examine the versatility and accuracy of fluorodeoxyglucose (FDG) PET/computed tomography (CT) in the metastasis detection of renal cell carcinoma (RCC). We also compared our findings to other similar studies from the literature. This is the biggest study so far to examine the sensitivity and specificity of FDG PET/CT in the management of RCC. A retrospective review was carried out on all the FDG PET/CT studies done from January 1999 to January 2014 at our institution. Biopsy results were considered the gold standard. For our patients (n = 315) with biopsy results, FDG PET/CT studies exhibited 100% sensitivity, 100% specificity. Our results were better than results achieved by other studies. The use of FDG PET/CT in restaging and metastasis detection of RCC has many advantages, in addition to high accuracy. This imaging technique has great potential in influencing treatment decisions. We recommend the incorporation of FDG PET/CT in routine standard protocols for RCC.
From quotient-difference to generalized eigenvalues and sparse polynomial interpolation

The numerical quotient-difference algorithm,or the qd-algorithm, can be used for determining the poles of a meromorphic function directly from its Taylor coeffcients. We show that the poles computed in the qd-algorithm, regardless of their multiplicities,are converging to the solution of a generalized eigenvalue problem. In a special case when all the poles are simple,such generalized eigenvalue problem can be viewed as a reformulation of Prony 's method,a method that is closely related to the Ben-Or/Tiwari algorithm for interpolating a multivariate sparse polynomial in computer algebra.
The glucose-pH relationship in parapneumonic effusions.

Both a low pleural fluid glucose concentration and pleural fluid acidosis are markers of severe pleural inflammation, but the relationship between these phenomena has not been defined clearly. Therefore, we measured simultaneous pleural fluid glucose concentrations and pH in 25 consecutive parapneumonic pleural fluids. Seventeen effusions had a glucose concentration greater than 60 mg/dl (group 1, 126 +/- 7 mg/dl, mean +/- SEM), while eight had a pleural fluid glucose less than 60 mg/dl (group 2, 15 +/- 3 mg/dl, P less than .01). Pleural fluid pH was 7.35 +/- 0.03 in group 1 compared with 6.83 +/- 0.09 in group 2 (P less than .01). A significant correlation between pleural fluid glucose and pH was found (r = .81, P less than .01). Low-glucose, low-pH effusions were complicated (either loculated or empyemas). Uncomplicated effusions had glucose concentrations greater than 60 mg/dl and a pleural fluid pH greater than 7.30. The concomitant occurrence of low pleural fluid glucose and pH suggests that the mechanisms leading to these phenomena are interrelated.
A Dual-Color Luciferase Assay System Reveals Circadian Resetting of Cultured Fibroblasts by Co-Cultured Adrenal Glands

In mammals, circadian rhythms of various organs and tissues are synchronized by pacemaker neurons in the suprachiasmatic nucleus (SCN) of the hypothalamus. Glucocorticoids released from the adrenal glands can synchronize circadian rhythms in other tissues. Many hormones show circadian rhythms in their plasma concentrations; however, whether organs outside the SCN can serve as master synchronizers to entrain circadian rhythms in target tissues is not well understood. To further delineate the function of the adrenal glands and the interactions of circadian rhythms in putative master synchronizing organs and their target tissues, here we report a simple co-culture system using a dual-color luciferase assay to monitor circadian rhythms separately in various explanted tissues and fibroblasts. In this system, circadian rhythms of organs and target cells were simultaneously tracked by the green-emitting beetle luciferase from Pyrearinus termitilluminans (ELuc) and the red-emitting beetle luciferase from Phrixothrix hirtus (SLR), respectively. We obtained tissues from the adrenal glands, thyroid glands, and lungs of transgenic mice that expressed ELuc under control of the promoter from a canonical clock gene, mBmal1. The tissues were co-cultured with Rat-1 fibroblasts as representative target cells expressing SLR under control of the mBmal1 promoter. Amplitudes of the circadian rhythms of Rat-1 fibroblasts were potentiated when the fibroblasts were co-cultured with adrenal gland tissue, but not when co-cultured with thyroid gland or lung tissue. The phases of Rat-1 fibroblasts were reset by application of adrenal gland tissue, whereas the phases of adrenal gland tissue were not influenced by Rat-1 fibroblasts. Furthermore, the effect of the adrenal gland tissue on the fibroblasts was blocked by application of a glucocorticoid receptor (GR) antagonist. These results demonstrate that glucocorticoids are strong circadian synchronizers for fibroblasts and that this co-culture system is a useful tool to analyze humoral communication between different tissues or cell populations.
Neural endophenotypes of social behavior in autism spectrum conditions

Autism is characterized by qualitative impairments in social interaction, communication, and stereotyped repetitive behaviors and/or restricted interests. Beyond these diagnostic criteria, autism is viewed as a neurodevelopmental condition with possibly several etiologies that manifest in complex patterns of atypical structural and functional brain development, cognition, and behavior. Despite the multidimensional nature of and substantial variation within the autism spectrum, impairments in social interaction remain among the most visible hallmarks of the condition. It is this profound developmental deficit in the social domain that makes autism a unique case in the field of social neuroscience. This chapter contributes to the dialogue amongst both the fields of autism research and social neuroscience by deliberately taking the stance of asking how we can understand more about the etiological mechanisms underlying social behavior in autism. It presents a multi-level overview of the literature on the behavioral, neural, and genetic underpinnings of social functioning in autism spectrum conditions (ASC). The main objective is to highlight the current state of the field regarding theory of mind/empathy difficulties in ASC, and then to suggest distinct candidate neural endophenotypes that can bridge the gap between social behavior and genetic mechanisms.
Rabies-Related Knowledge and Practices Among Persons At Risk of Bat Exposures in Thailand

Background Rabies is a fatal encephalitis caused by lyssaviruses. Evidence of lyssavirus circulation has recently emerged in Southeast Asian bats. A cross-sectional study was conducted in Thailand to assess rabies-related knowledge and practices among persons regularly exposed to bats and bat habitats. The objectives were to identify deficiencies in rabies awareness, describe the occurrence of bat exposures, and explore factors associated with transdermal bat exposures. Methods A survey was administered to a convenience sample of adult guano miners, bat hunters, game wardens, and residents/personnel at Buddhist temples where mass bat roosting occurs. The questionnaire elicited information on demographics, experience with bat exposures, and rabies knowledge. Participants were also asked to describe actions they would take in response to a bat bite as well as actions for a bite from a potentially rabid animal. Bivariate analysis was used to compare responses between groups and multivariable logistic regression was used to explore factors independently associated with being bitten or scratched by a bat. Findings Of 106 people interviewed, 11 (10%) identified bats as a potential source of rabies. A history of a bat bite or scratch was reported by 29 (27%), and 38 (36%) stated either that they would do nothing or that they did not know what they would do in response to a bat bite. Guano miners were less likely than other groups to indicate animal bites as a mechanism of rabies transmission (68% vs. 90%, p = 0.03) and were less likely to say they would respond appropriately to a bat bite or scratch (61% vs. 27%, p = 0.003). Guano mining, bat hunting, and being in a bat cave or roost area more than 5 times a year were associated with history of a bat bite or scratch. Conclusions These findings indicate the need for educational outreach to raise awareness of bat rabies, promote exposure prevention, and ensure appropriate health-seeking behaviors for bat-inflicted wounds, particularly among at-risk groups in Thailand.
Distributed data association for Multi-target tracking in sensor networks

In this paper, we explore the problem of tracking multiple targets through a field of sensors. Each sensor node is capable of making noisy measurements of the targets¿ positions, performing on-board computation, and wirelessly transmitting information to neighboring nodes. The problem of multitarget tracking (MTT) can be decomposed into two main fusion problems: estimation and data association. Using Kalman-consensus filtering (KCF), introduced by Olfati-Saber, the authors have recently addressed distributed estimation in tracking for a single target. Data association techniques for multitarget tracking are categorized by how many time-indexed sets of measurements are made before the associations are considered ¿fixed¿. Most multitarget tracking algorithms perform the data association at a central processing node through a multiple-scan method such as multiple hypothesis tracking (MHT), or single-scan techniques such as joint probabilistic data association (JPDA), Markov Chain Monte Carlo methods (MCMC), or optimal graph matching. Here, the main contribution is to introduce data association algorithms for ¿distributed¿ multitarget tracking. A formulation of joint probabilistic data association for Kalman-Consensus Filtering is formally derived. Simulations are provided to demonstrate the effectiveness of our distributed multitarget tracking algorithm for tracking multiple maneuvering targets in the sensing environment of a sensor network with 25 nodes.
Wavelet Transforms That Map Integers to Integers

Abstract Invertible wavelet transforms that map integers to integers have important applications in lossless coding. In this paper we present two approaches to build integer to integer wavelet transforms. The first approach is to adapt the precoder of Laroiaet al.,which is used in information transmission; we combine it with expansion factors for the high and low pass band in subband filtering. The second approach builds upon the idea of factoring wavelet transforms into so-called lifting steps. This allows the construction of an integer version of every wavelet transform. Finally, we use these approaches in a lossless image coder and compare the results to those given in the literature.