Miracle-dz/UniFAR-FTUs huggingface dataset:
Lipopolysaccharide Renders Transgenic Mice Expressing Human Serum Amyloid P Component Sensitive to Shiga Toxin 2

Transgenic C57BL/6 mice expressing human serum amyloid P component (HuSAP) are resistant to Shiga toxin 2 (Stx2) at dosages that are lethal in HuSAP-negative wild-type mice. However, it is well established that Stx2 initiates extra-intestinal complications such as the haemolytic-uremic syndrome despite the presence of HuSAP in human sera. We now demonstrate that co-administering purified Escherichia coli O55 lipopolysaccharide (LPS), at a dosage of 300 ng/g body weight, to HuSAP-transgenic mice increases their susceptibility to the lethal effects of Stx2. The enhanced susceptibility to Stx2 correlated with an increased expression of genes encoding the pro-inflammatory cytokine TNFα and chemokines of the CXC and CC families in the kidneys of LPS-treated mice, 48 hours after the Stx2/LPS challenge. Co-administering the glucocorticoid dexamethasone, but not the LPS neutralizing cationic peptide LL-37, protected LPS-sensitized HuSAP-transgenic mice from lethal doses of Stx2. Dexamethasone protection was specifically associated with decreased expression of the same inflammatory mediators (CXC and CC-type chemokines and TNFα) linked to enhanced susceptibility caused by LPS. The studies reveal further details about the complex cascade of host-related events that are initiated by Stx2 as well as establish a new animal model system in which to investigate strategies for diminishing serious Stx2-mediated complications in humans infected with enterohemorrhagic E. coli strains.
DIRECTION GÉNÉRALE DES ÉTUDES ET DES RELATIONS INTERNATIONALES GLOBAL SOURCING UNDER IMPERFECT CAPITAL MARKETS

We develop a simple model to study the interactions between a supplier’s financial constraints and contract incompleteness in a vertical relationship. Production complexity increases the extent of contract incompleteness and the hold-up problem, which generates a cost when the supplier needs financial participation from the downstream firm. Vertical integration alleviates the impact of financial constraints but reduces the supplier’s incentives. We apply the model to an analysis of multinational firms’ sourcing strategies and predict that (1) complex and specific inputs are more likely to be sourced from financially developed countries and (2) multinationals are more likely to integrate suppliers located in countries with poor financial institutions, especially when trade involves complex goods. We examine and validate these predictions using firm-level trade data on multinational firms with operations in France. We provide evidence that financial development generates a comparative advantage in the supply of complex goods. Moreover, we find higher shares of intra-firm imports of complex inputs from countries with a lower level of financial development. The findings are robust to different measures of complexity and specificity, and are not driven by industry differences in fixed costs or traditional measures of external financial dependence. Quantitatively, we find that financial development is as important as contract enforcement in alleviating hold-up problems.
An ERP Investigation of Binding and Coreference

This study examines the nature of violations in processing one class of binding construction, namely those involving reflexives and their antecedents. When arguments of verbs appear at the point where a syntactic violation is detected, a centroparietal positivity occurs, peaking at 600 ms after the presentation of the stimulus (P600), as is consistent with other types of syntactic anomalies. However, nonarguments in similar sentences fail to elicit the same response. For example, the reflexive in "John's brothers like himself" is in an argument position and elicits the P600 when compared to its grammatical counterpart. The nonargument, participating in the same type of mismatch, "John's brothers like Bill and himself," does not elicit the same positivity. This provides evidence that there are two processes involved in parsing this binding construction, one syntactic and another as yet unidentified, perhaps involving meaning or pragmatics.
Causal Inference Using Potential Outcomes

Causal effects are defined as comparisons of potential outcomes under different treatments on a common set of units. Observed values of the potential outcomes are revealed by the assignment mechanism—a probabilistic model for the treatment each unit receives as a function of covariates and potential outcomes. Fisher made tremendous contributions to causal inference through his work on the design of randomized experiments, but the potential outcomes perspective applies to other complex experiments and nonrandomized studies as well. As noted by Kempthorne in his 1976 discussion of Savage's Fisher lecture, Fisher never bridged his work on experimental design and his work on parametric modeling, a bridge that appears nearly automatic with an appropriate view of the potential outcomes framework, where the potential outcomes and covariates are given a Bayesian distribution to complete the model specification. Also, this framework crisply separates scientific inference for causal effects and decisions based on such inference, a distinction evident in Fisher's discussion of tests of significance versus tests in an accept/reject framework. But Fisher never used the potential outcomes framework, originally proposed by Neyman in the context of randomized experiments, and as a result he provided generally flawed advice concerning the use of the analysis of covariance to adjust for posttreatment concomitants in randomized trials.
Oral health-related quality-of-life in Swedish children before and after dental treatment under general anesthesia

Abstract Objective. This study evaluated oral health-related quality-of-life (OHRQoL) in children and families before and after dental treatment under general anesthesia because of severe caries or molar-incisor hypomineralization (MIH). Materials and methods. A consecutive sample of the parents/caregivers of children (3–14 years) in need of treatment under general anesthesia participated in the study. The children were divided into two groups: 3–6 years and 7–14 years. The 49-item questionnaire that was administered before and after general anesthesia comprised the Child Oral Health Quality of Life-components of the Parental-Caregivers Perception Questionnaire (P-CPQ), the Family Impact Scale (FIS) and two global questions concerning oral health and general well-being. The P-CPQ domains were Oral symptoms, Functional limitations, Emotional well-being and Social well-being. The FIS items assessed impact on family life. Results. In both age groups, a significant decrease (p < 0.001) occurred in overall P-CPQ and the Oral symptoms, Functional limitations and Emotional limitations domains of the P-CPQ. Mean values for the Social well-being domain decreased significantly in the older (p < 0.05) but not the younger age group. Mean values for FIS decreased significantly in the younger (p < 0.001) and the older (p < 0.05) age groups. Conclusions. Dental treatment of severe caries or MIH, performed under general anesthesia, had an immediate effect on the oral health-related quality-of-life in the children in this study and a positive impact on the family situation.
Antidiarrheal, Antioxidant and Antimicrobial Activities of the Musa sapientum Seed

Musa sapientum (M.sapientum) commonly known as ‘banana’ is widely used in Bangladeshi folk medicine for the treatment of various ailments including diarrhea. Hence, the present study was designed to investigate antidiarrheal, antioxidant and antibacterial potential of the methanolic extract of M.sapientum seed (MMSS). The extract was studied for antidiarrheal property using castor oil and magnesium sulfate induced diarrheal model and charcoal induced gastrointestinal motility test in mice. Total phenolic and flavonoids content, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as nitric oxide (NO) and assessment of reducing power were used to evaluate antioxidant potential of MMSS. In addition, disc diffusion methods were used for antibacterial assay using various diarrheal induced bacterial strains. At the doses of 100 and 200 mg/kg body weight, the extract reduced the frequency and severity of diarrhea in test animals throughout the study period. At the same doses, the extracts significantly (p<0.001) delayed the intestinal transit of charcoal meal in test animals as compared to the control. In DPPH and NO scavenging method, MMSS showed good antioxidant potentiality in a dose dependent manner with the IC50 value of 12.32±0.33 µg/ml and 18.96±1.01 µg/ml, respectively with a significant (p<0.001) good reducing power. The extract also displayed strong anti-bacterial effect against when tested against Escherichia coli, Shigella dysenteriae, and Pseudomonas aeruginosa. Altogether, these results suggest that the MMSS could be used as a potential antidiarrheal agent along with its antioxidant and antibacterial potentiality.
Taking a closer look: disentangling effects of functional diversity on ecosystem functions with a trait-based model across hierarchy and time

Biodiversity and ecosystem functioning (BEF) research has progressed from the detection of relationships to elucidating their drivers and underlying mechanisms. In this context, replacing taxonomic predictors by trait-based measures of functional composition (FC)—bridging functions of species and of ecosystems—is a widely used approach. The inherent challenge of trait-based approaches is the multi-faceted, dynamic and hierarchical nature of trait influence: (i) traits may act via different facets of their distribution in a community, (ii) their influence may change over time and (iii) traits may influence processes at different levels of the natural hierarchy of organization. Here, we made use of the forest ecosystem model ‘LPJ-GUESS’ parametrized with empirical trait data, which creates output of individual performance, community assembly, stand-level states and processes. To address the three challenges, we resolved the dynamics of the top-level ecosystem function ‘annual biomass change’ hierarchically into its various component processes (growth, leaf and root turnover, recruitment and mortality) and states (stand structures, water stress) and traced the influence of different facets of FC along this hierarchy in a path analysis. We found an independent influence of functional richness, dissimilarity and identity on ecosystem states and processes and hence biomass change. Biodiversity effects were only positive during early succession and later turned negative. Unexpectedly, resource acquisition (growth, recruitment) and conservation (mortality, turnover) played an equally important role throughout the succession. These results add to a mechanistic understanding of biodiversity effects and place a caveat on simplistic approaches omitting hierarchical levels when analysing BEF relationships. They support the view that BEF relationships experience dramatic shifts over successional time that should be acknowledged in mechanistic theories.
Political Differences in Past, Present, and Future Life Satisfaction: Republicans Are More Sensitive than Democrats to Political Climate

Previous research finds that Republicans report being happier or more satisfied with their lives than Democrats. Using representative American samples from 2002, 2005, 2007, 2009, and 2010, we tested a Person × Situation interactionist account in which political affiliation (Democrat, Republican) and political climate (favorable when the president in office is of the same party) are proposed to affect past, present, and anticipated future life satisfaction. Meta-analyses of related tests of key hypotheses confirmed that (a) life satisfaction was greater when the political climate was favorable rather than unfavorable and (b) Republicans were more sensitive to political climate than Democrats. As predicted, Republicans also were more politically polarized than Democrats. Taken together, the findings indicate that, compared to Democrats, Republicans are more apt to self-identify in political terms, and core aspects of their subjective well-being are more easily affected by the outcome of political events.
Awareness of osteoporosis in postmenopausal Indian women: An evaluation of Osteoporosis Health Belief Scale

Context: The level of awareness about osteoporosis in postmenopausal women who are the common sufferers. Aims: This study aims to evaluate the level of awareness in postmenopausal women using the Osteoporosis Health Belief Scale (OHBS). Settings and Design: Osteoporosis has emerged as a common health problem in geriatric population. A proactive role needs to be played for preventing its consequences. Before initiating any preventive measures, an evaluation of awareness level of the target population is necessary. The questionnaire-based study design was used for this study. Subjects and Methods: A questionnaire (OHBS)-based study in 100 postmenopausal women in Chandigarh was conducted. The bone mineral density (BMD) was measured in each case by dual energy X-ray absorptiometry. Height, weight, and body mass index (BMI) of the participants were noted. Statistical Analysis Used: Statistical analysis was conducted to evaluate any correlation between the various components of the OHBS and the BMD. Results: No statistically significant difference was noted in the seven component parameters of OHBS among the normal, osteopenic, and osteoporotic women suggesting that the health belief regarding susceptibility is not much different between the three groups of the study population. A statistically significant difference between the mean BMI of normal and osteoporotic population was noted. Conclusions: The results show that there is a great deficit in the awareness level of postmenopausal Indian women regarding osteoporosis. Most of the women were unaware of the condition and the means to prevent it. The study emphasizes that health care professionals have lot of ground to cover to decrease the incidence of osteoporosis and its associated health problem.
A Vesiculovirus Showing a Steepened Transcription Gradient and Dominant trans-Repression of Virus Transcription

ABSTRACT Vesicular stomatitis virus (VSV) is a prototype nonsegmented, negative-sense virus used to examine viral functions of a broad family of viruses, including human pathogens. Here we demonstrate that S2 VSV, an isolate with a small plaque phenotype compared to other Indiana strain viruses, has a transcription defect resulting in an altered pattern and rapid decline of transcription. The S2 VSV transcription gradient is dominant over the wild-type transcription in a coinfection. This is the first characterization of an altered gradient of transcription not dependent on RNA template sequence or host response and may provide insight into new approaches to viral attenuation.
Person re-ID while Crossing Different Cameras: Combination of Salient-Gaussian Weighted BossaNova and Fisher Vector Encodings

Person re-identification (re-ID) is a challenging task in the camera surveillance field, since it addresses the problem of re-identifying people across multiple non-overlapping cameras. Most of existing approaches have been concentrated on: 1) achieving a robust and effective feature representation; and 2) enforcing discriminative metric learning to predict if two images represent the same identity. In this context, we present a new approach for person re-ID built upon multi-level descriptors. This is achieved by combining three complementary representations: salient-Gaussian Fisher Vector (SGFV) encoding method, salient-Gaussian BossaNova (SGBN) histogram encoding method and deep Convolutional Neural Network (CNN) features. The two first methods adapt the histogram encoding framework to the person re-ID task. This is achieved by integrating the pedestrian saliency map and the spatial location information, in the histogram encoding process. On one hand, human saliency is reliable and distinctive in the person re-ID task, since it can model the uniqueness of the identity. On the other hand, localizing a person in the image can effectively discard noisy background information. Finally, one of the most advanced metric learning in person re-ID: the Cross-view Quadratic Discriminant Analysis (XQDA) is applied on the top of the resulting description. The proposed method yields promising person re-ID results on two challenging image-based person re-ID benchmarks: CUHK03 and Market-1501.
Effects of air pollution on tomato plants (Lycopersicon esculentum) grown along Waiyaki highway in Nairobi County, Kenya

xiii . LIST OF ABBREVIATIONS AND ACRONYMS . xiii CHAPTER ONE: INTRODUCTION . 1 1.0 Background Information . 1 1.1 Statement of the Problem . 2 1.3 Objectives . 3 1.3. 1 General Objective . 3 1.3. 2 Specific Objectives . 3 1.4 Research Hypotheses . 4 1.5 The Conceptual Framework . 4 1.6 Justification of the Study . 5 1.7 Significant of the Study . 6 CHAPTER TWO: LITERATURE REVIEW . 7 2.0. Introduction . 7 2.1 Air Pollution in the World . 7 2.2 Air Pollution in Africa . 11 2.3 Air Pollution in eastern Africa . 12 2.4 Air Pollution in Kenya . 13
Cytotoxic, antioxidant and phytochemical analysis of Gracilaria species from Persian Gulf

Background: Marine algae, also called seaweeds, are abundantly present in the coastal area of Iran, especially in Persian Gulf. These plants contain important phytochemical constituents and have potential biological activities. The present study investigated the presence of phytochemical constituents and total phenolic quantification of the seaweeds Gracilaria salicornia and Gracilaria corticata. Cytotoxicity of seaweeds was tested against HT-29, HeLa, and MCF-7 cell lines. Antioxidant potential of these two Gracilaria species was also analyzed. Materials and Methods: Extracts of G. salicornia and G. corticata were subjected to phytochemical and cytotoxicity tests. Phytochemical screenings were employed to identify the chemical constituents and total phenolic content. Cytotoxicity was characterized by IC50of human cancer cell lines (MCF-7, HeLa, and HT-29) using sulforhodamine assay. Antioxidant activities were evaluated using 2,2-diphenyl-1-picrylhydrazyl. Results: The analysis revealed that tannins were the most abundant compounds in G. corticata while sterols and triterpenes were the most abundant ones in G. salicornia, but the total phenolic content of the two seaweeds was similar. Cytotoxic results showed that both species could inhibit cell growth effectively, especially against HT-29 cell line. Conclusion: Considerable phytochemicals, high antioxidant potential, and moderate cytotoxic activity of G. salicornia and G. corticata make them appropriate candidates for further studies and identification of their bioactive principles.
Regulation of Volume-Sensitive Osmolyte Efflux from Human SH-SY5Y Neuroblastoma Cells following Activation of Lysophospholipid Receptors

The ability of the lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) to promote the release of the organic osmolyte taurine in response to hypoosmotic stress has been examined. Incubation of SH-SY5Y neuroblastoma cells under hypoosmotic conditions (230 mOsM) resulted in a time-dependent release of taurine that was markedly enhanced (3–7-fold) by the addition of micromolar concentrations of either S1P or LPA. At optimal concentrations, the effects of S1P and LPA on taurine efflux were additive and mediated via distinct receptors. Inclusion of 1,9-dideoxyfoskolin, 5-nitro-2-(3-phenylpropylamino benzoic acid, or 4-[(2-butyl-6,7-dicloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-butanoic acid blocked the ability of both lysophospholipids to enhance taurine release, indicating the mediation of a volume-sensitive organic osmolyte and anion channel. Both S1P and LPA elicited robust increases in intracellular calcium concentration that were attenuated by the removal of extracellular calcium, abolished by the depletion of intracellular calcium with thapsigargin, and were independent of phosphoinositide turnover. Taurine efflux mediated by S1P and LPA was unaffected by the removal of extracellular calcium but was attenuated by depletion of intracellular calcium (34–38%) and by inhibition of protein kinase C (PKC) with chelerythrine (38–72%). When intracellular calcium was depleted and PKC was inhibited, S1P- or LPA-stimulated taurine efflux was inhibited by 80%. Pretreatment of the cells with pertussis toxin, toxin B, or cytochalasin D had no effect on lysophospholipid-stimulated taurine efflux. The results indicate that both S1P and LPA receptors facilitate osmolyte release via a phospholipase C-independent mechanism that requires the availability of intracellular calcium and PKC activity.
Approximate Degradable Quantum Channels

Degradable quantum channels are an important class of completely positive trace-preserving maps. Among other properties, they offer a single-letter formula for the quantum and the private classical capacity and are characterized by the fact that a complementary channel can be obtained from the channel by applying a degrading channel. In this paper, we introduce the concept of approximate degradable channels, which satisfy this condition up to some finite <inline-formula> <tex-math notation="LaTeX">$\varepsilon \geq 0$ </tex-math></inline-formula>. That is, there exists a degrading channel which upon composition with the channel is <inline-formula> <tex-math notation="LaTeX">$\varepsilon $ </tex-math></inline-formula>-close in the diamond norm to the complementary channel. We show that for any fixed channel the smallest such <inline-formula> <tex-math notation="LaTeX">$\varepsilon $ </tex-math></inline-formula> can be efficiently determined via a semidefinite program. Moreover, these approximate degradable channels also approximately inherit all other properties of degradable channels. As an application, we derive improved upper bounds to the quantum and private classical capacity for certain channels of interest in quantum communication.
The methodology and an application to fight against Unicode attacks

Unicode is becoming a dominant character representation format for information processing. This presents a very dangerous usability and security problem for many applications. The problem arises because many characters in the UCS (Universal Character Set) are visually and/or semantically similar to each other. This presents a mechanism for malicious people to carry out Unicode Attacks, which include spam attacks, phishing attacks, and web identity attacks. In this paper, we address the potential attacks, and propose a methodology for countering them. To evaluate the feasibility of our methodology, we construct a Unicode Character Similarity List (UC-SimList). We then implement a visual and semantic based edit distance (VSED), as well as a visual and semantic based Knuth-Morris-Pratt algorithm (VSKMP), to detect Unicode attacks. We develop a prototype Unicode attack detection tool, IDN-SecuChecker, which detects phishing weblinks and fake user name (account) attacks. We also introduce the possible practical use of Unicode attack detectors.