Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonapnea Sleep Disorders in Patients Younger than 65 Years Are Significantly Associated with CKD: A Nationwide Population-Based Study

Background Nonapnea sleep disorders (NASD) and sleep-related problems are associated with poor health outcomes. However, the association between NASD and the development and prognosis of chronic kidney disease (CKD) has not been investigated thoroughly. We explored the association between CKD and NASD in Taiwan. Methods We conducted a population-based study using the Taiwan National Health Insurance database with1,000,000 representative data for the period from January 1, 2000 to December 31, 2009. We investigated the incidence and risk of CKD in 7,006 newly diagnosed NASD cases compared with 21,018 people without NASD matched according to age, sex, index year, urbanization, region, and monthly income at a 1:3 ratio. Results The subsequent risk of CKD was 1.48-foldhigher in the NASD cohort than in the control cohort (95% confidence interval [CI] = 1.26–1.73, p< 0.001). Men, older age, type 2 diabetes mellitus, and gout were significant factors associated with the increased risk of CKD (p< 0.001). Among different types of NASDs, patients with insomnia had a 52% increased risk of developing CKD (95%CI = 1.23–1.84; P<0.01), whereas patients with sleep disturbance had a 49%increased risk of subsequent CKD (95% CI = 1.19–1.87; P<0.001). Younger women (aged < 65 years) were at a high risk of CKD with NASD (adjusted hazard ratio, [HR] = 1.81; 95% CI = 1.35–2.40, p< 0.001). Conclusions In this nationwide population-based cohort study, patients with NASD, particularly men of all ages and women aged younger than 65 years, were at high risk of CKD.
Sulfonylurea Treatment of Type 2 Diabetes Mellitus: Focus on Glimepiride

Sulfonylureas, which have evolved through two generations since their introduction nearly 50 years ago, remain the most frequently prescribed oral agents for treatment of patients with type 2 diabetes mellitus. Glyburide, glipizide, and glimepiride, the newest sulfonylureas, are as effective at lowering plasma glucose concentrations as first‐generation agents but are more potent, better tolerated, and associated with a lower risk of adverse effects. Differences in their binding affinity to the β‐cell sulfonylurea receptor have been described, with preservation of cardioprotective responses to ischemia with glimepiride. Clinical studies have shown glimepiride to be safe and effective in reducing fasting and postprandial glucose levels, as well as glycosylated hemoglobin concentrations, with dosages of 1–8 mg/day. In comparative trials, glimepiride was as effective in lowering glucose levels as glyburide and glipizide, but glimepiride was associated with a reduced likelihood of hypoglycemia and a smaller increase in fasting insulin and C‐peptide levels than glyburide, and a more rapid lowering of fasting plasma glucose levels than glipizide. Glimepiride also improves first‐phase insulin secretion, which plays an important role in reducing postprandial hyperglycemia. Insulin secretagogues, specifically glimepiride, merit consideration as first‐line therapy for patients with type 2 diabetes.
Characteristics of 351 supernumerary molar teeth In Turkish population

Objective: The aim of the present study was to evaluate the demographic profile of supernumerary molar (SM) teeth in people in various regions of Turkey. Study Design: A retrospective analysis was carried out on an initial sample of 104,902 subjects drawn from the ortopantographics files from 10 clinics in 7 Turkish cities with documentation of demographic data, the presence of SM teeth, their location, eruption, morphology, and position within the arch. In one region associated pathologies and treatments were also evaluated. Results: Three hundred fifty-one SMs were detected in 288 patients, constituting 0.33% of the study subjects, with a greater frequency in females (56.4%). SMs were found more frequently in the maxilla (87.7%) than in the mandible, and distomolars (62.9%) were more common than paramolars. The SMs encountered were mostly of conical shape (45.7%), impacted (81.1%), and in a vertical position (52.1). The 33% of SM teeth were related to impacted molar teeth. Conclusion: The most common complication involving these teeth was soft tissue irritation. Demographic data from such specific extensive studies are crucial for improved diagnosis of SM teeth. Early detection allows for measures against complications and more successful therapy. Key words:Supernumerary molars, distomolar, paramolar, prevalence.
E3 Ubiquitin Ligase Pub1 Is implicated in Endocytosis of a GPI-Anchored Protein Ecm33 in Fission Yeast

We previously identified three glycosylphosphatidylinositol (GPI)-anchored proteins including Ecm33, as multicopy suppressors of the phenotypes of a mutant allele of cis4+ that encodes a zinc transporter in fission yeast. Here, we further identified two multicopy suppressor genes, ubi1 + and ubc4 +, encoding ubiquitin-ribosomal fusion protein and ubiquitin conjugating enzyme E2, respectively. In addition, Ubi1 or Ubc4 overexpression failed to suppress the phenotypes of the double deletion of cis4 + and pub1 + gene, which encodes a HECT-type ubiquitin ligase E3. During exponential phase GFP-Ecm33 localized at the growing cell tips of the cell surface and the medial region in wild-type cells. Notably, during the post-exponential and stationary phase, GFP-Ecm33 in wild-type cells was internalized and mostly localized to the Golgi/endosomes, but it was still stably localized at the cell surface in Δpub1 cells. The Δpub1 cells showed osomoremedial phenotypes to various drugs indicating their defects in cell wall integrity. Altogether, our findings reveal a novel role for Pub1 in endocytosis of Ecm33 and regulation of cell wall integrity in fission yeast.
Binaries discovered by the SPY survey - VI. Discovery of a low mass companion to the hot subluminous planetary nebula central star EGB 5 – a recently ejected common envelope?

Hot subdwarf B stars (sdBs) in close binary systems are assumed to be formed via common envelope ejection. According to theoretical models, the amount of energy and angular momentum deposited in the common envelope scales with the mass of the companion. That low mass companions near or below the core hydrogen-burning limit are able to trigger the ejection of this envelope is wel l known. The currently known systems have very short periods'0: 1−0: 3 d. Here we report the discovery of a low mass companion (M2> 0: 14 M�) orbiting the sdB star and central star of a planetary nebula E GB 5 with an orbital period of 16: 5 d at a minimum separation of 23 R�. Its long period is only just consistent with the energy balan ce prescription of the common envelope. The marked difference between the short and long period systems will provide strong constraints on the common envelope phase, in particular if the masses of the sdB stars can be measured accurately. Due to selection effects, the fraction of sdBs with low mass companions and similar or longer periods may be quite high. Low mass stellar and substellar companions may therefore play a significant role for the still u nclear formation of hot subdwarf stars. Furthermore, the nebula around EGB 5 may be the remnant of the ejected common envelope making this binary a unique system to study this short und poorly understood phase of binary evolution.
SecDep: A user-aware efficient fine-grained secure deduplication scheme with multi-level key management

Nowadays, many customers and enterprises backup their data to cloud storage that performs deduplication to save storage space and network bandwidth. Hence, how to perform secure deduplication becomes a critical challenge for cloud storage. According to our analysis, the state-of-the-art secure deduplication methods are not suitable for cross-user finegrained data deduplication. They either suffer brute-force attacks that can recover files falling into a known set, or incur large computation (time) overheads. Moreover, existing approaches of convergent key management incur large space overheads because of the huge number of chunks shared among users. Our observation that cross-user redundant data are mainly from the duplicate files, motivates us to propose an efficient secure deduplication scheme SecDep. SecDep employs User-Aware Convergent Encryption (UACE) and Multi-Level Key management (MLK) approaches. (1) UACE combines cross-user file-level and inside-user chunk-level deduplication, and exploits different secure policies among and inside users to minimize the computation overheads. Specifically, both of file-level and chunk-level deduplication use variants of Convergent Encryption (CE) to resist brute-force attacks. The major difference is that the file-level CE keys are generated by using a server-aided method to ensure security of cross-user deduplication, while the chunk-level keys are generated by using a user-aided method with lower computation overheads. (2) To reduce key space overheads, MLK uses file-level key to encrypt chunk-level keys so that the key space will not increase with the number of sharing users. Furthermore, MLK splits the file-level keys into share-level keys and distributes them to multiple key servers to ensure security and reliability of file-level keys. Our security analysis demonstrates that SecDep ensures data confidentiality and key security. Our experiment results based on several large real-world datasets show that SecDep is more time-efficient and key-space-efficient than the state-of-the-art secure deduplication approaches.
Tissue uptake, distribution, and potency of the photoactivatable dye chloroaluminum sulfonated phthalocyanine in mice bearing transplantable tumors.

The potency of chloroaluminum sulfonated phthalocyanine (ClAlSPc) as a photosensitizing agent for photodynamic therapy of cancer was evaluated in vivo by its ability to be taken up and retained by murine tumors of diverse histological origin. Antitumor effects following laser irradiation were evaluated by measurement of the tumor weights of dissected-out tumor masses. Three tumors (Colo 26, a colorectal carcinoma; M5076, a reticulum cell sarcoma; and UV-2237, a fibrosarcoma) growing s.c. in the flank region retained substantially greater quantities of ClAlSPc than did adjacent skin and muscle achieving peak values 24-48 h after the i.v. administration of ClAlSPc (10 mg/kg). The relative magnitude of ClAlSPc retention by these tumors was Colo 26 greater than M5076 greater than UV-2237. However, normal liver and spleen were organs which retained the greatest amounts of ClAlSPc even compared to the s.c. grown tumors and other normal tissues examined. Flow cytometric analysis of tumor cell suspensions obtained from collagenase-digested tumors showed that individual neoplastic cells were capable of taking up and retaining ClAlSPc. Photodynamic therapy, undertaken by i.v. administration of dye (5 mg/kg) followed 24 h later by local laser light irradiation (675 nm, 100 J), brought about significant (Colo 26, M5076, and 3LL tumors) and obvious but nonsignificant (UV-2237 tumor) reductions in tumor weights, as assessed 5 days later. Thus, selective tumor retention of ClAlSPc coupled with a significant response to red light produced dramatic alterations in cancer growth.
Need for Improvement in Current Treatment of Psoriatic Arthritis: Study of an Outpatient Clinic Population

Objective. To explore the burden of skin, joint, and entheses manifestations in a representative psoriatic arthritis (PsA) outpatient cohort in the biologic treatment era. Methods. This was a cross-sectional study of 141 PsA outpatients fulfilling the ClASsification for Psoriatic ARthritis (CASPAR) criteria and examined between January 2013 and May 2014. Selected disease activity measures were explored including Disease Activity index for PSoriatic Arthritis (DAPSA), Composite Psoriatic Disease Activity Index (CPDAI), Psoriatic Arthritis Disease Activity Score (PASDAS), Disease Activity Score for 28 joints (DAS28), Simplified Disease Activity Index (SDAI), and Psoriasis Area Severity Index (PASI). Dermatology Life Quality Index (DLQI), minimal disease activity (MDA), and remission criteria were assessed. Results. Median (range) DAPSA was 14.5 (0.1–76.4), CPDAI 5 (1–11), PASDAS 3.1 (2.1–4.2), DAS28-erythrocyte sedimentation rate (ESR) 3.2 (0.6–6.4), SDAI 8.6 (0.1–39.5), PASI 1.2 (0.0–19.7), and DLQI 2.0 (0–17). The MDA criteria were fulfilled by 22.9% of the patients. DAPSA ≤ 4, CPDAI ≤ 2, PASDAS < 2.4, DAS28-ESR < 2.4, SDAI < 3.3, and Boolean’s remission criteria were fulfilled by 12.1, 9.3, 7.8, 26.2, 21.3, and 5.7% of patients, respectively. The number of satisfied patients was similar regardless of whether the group was treated with tumor necrosis factor inhibitors. Conclusion. Our real-life data indicate that there is still a need for improvement in today’s treatment of PsA. Musculoskeletal inflammatory involvement was more prominent than psoriatic skin involvement. Only a few patients fulfilled the DAPSA, PASDAS, and CPDAI remission criteria, and about a quarter fulfilled the MDA criteria. Considerably fewer patients fulfilled PsA-specific remission criteria versus non-PsA specific remission criteria. Still, patient satisfaction was good and PASI and DLQI were low.
Cell death is prevented in thalamic fields but not in injured neocortical areas after permanent focal ischaemia in mice overexpressing the anti‐apoptotic protein Bcl‐2

Previous studies have suggested that various apoptotic‐related proteins could be involved in the death process induced by cerebral ischaemia. In order to further clarify their role and examine how the anti‐apoptotic protein Bcl‐2 could influence this process, the time‐course of mRNA expression of various cell death genes was studied from 1 to 14 days following permanent occlusion of the middle cerebral artery in wild‐type (WT) and Bcl‐2 transgenic mice, within and outside the area of infarction. No differences of the infarct sizes were observed between the two groups of mice, showing that the extent of neuronal injury could not have been lowered by the Bcl‐2 transgene. Seven days after the ischaemic insult, the mRNA expression of the cell death gene effector cpp32 was dramatically upregulated in the penumbra of WT and Bcl‐2 transgenic mice. Interestingly, the cpp32 transcript was markedly induced from 3 days in the ipsilateral thalamus of the two groups of mice. However, apoptotic bodies were observed in the thalamic field of WT but not transgenic mice. This suggests that cpp32 mRNA may be induced in an attempt to kill the injured cells and, in contrast to the penumbra, cell death in the thalamus may be prevented in Bcl‐2 transgenic mice. Based on these results, the pathophysiological mechanisms that underly neuronal damage following ischaemia need consideration in order to evaluate the extent of neuroprotection that may be afforded by the Bcl‐2 anti‐apoptotic protein. Although the present study does not confirm previous data showing a protective role of Bcl‐2 in neocortical infarcted areas, it suggests that anti‐apoptotic therapies may constitute a possible treatment for areas of the brain remote from those directly affected by ischaemia.
Recovering code to documentation links in OO systems

Software system documentation is almost always expressed informally, in natural language and free text. Examples include requirement specifications, design documents, user manual pages, system development journals, error logs and related maintenance reports. We propose an approach to establish and maintain traceability links between the source code and free-text documents. A premise of our work is that programmers use meaningful names for program's items, such as functions, variables, types, classes and methods. We believe that the application domain knowledge that programmers process when writing the code is often captured by the mnemonics for identifiers; therefore, the analysis of these mnemonics can help to associate high-level concepts with program concepts, and vice versa. In this paper, the approach is applied to software written in an object-oriented (OO) language, namely C++, to trace classes to manual sections.
Effects of short-term CPAP withdrawal on neurobehavioral performance in patients with obstructive sleep apnea.

STUDY OBJECTIVE Changes in sleep parameters and neurobehavioral functioning were systematically investigated after an acute (1 night) and short-term (7 nights) period of withdrawal from continuous positive airway pressure (CPAP) treatment and 1 subsequent night of CPAP reintroduction in patients with obstructive sleep apnea. DESIGN Repeated-measurement within-subject design. SETTING Sleep laboratory, university teaching hospital. PARTICIPANTS Twenty participants receiving optimal CPAP therapy for > or = 12 months. INTERVENTIONS CPAP withdrawal. MEASUREMENTS AND RESULTS Polysomnograms were performed on Night 0 (with CPAP), Night 1 and Night 7 (without CPAP) and Night 8_R (with CPAP). Acute CPAP withdrawal resulted in the recurrence of sleep-disordered breathing with sleep disruption, hypoxemia, and increased subjective sleepiness. Short-term CPAP withdrawal exacerbated hypoxemia, increased subjective and objective sleepiness and poor mood ratings. Neurobehavioral functioning assessed using the Psychomotor Vigilance Task was impaired following Night 7 and associated with hypoxemia and changes in morning levels of tumor necrosis factor-alpha. However, other neurobehavioral measures were not affected. Autonomic arousals measured via respiratory-related reductions in finger blood volume by peripheral arterial tonometry decreased from Night 1 to Night 7. On Night 8_R, reintroduction of CPAP treatment eliminated most airway obstruction, maintained oxygenation, and reversed daytime sleepiness and some vigilance decrements. CONCLUSION Despite recurrence of sleep-disordered breathing with increased sleepiness and impaired vigilance, most neurobehavioral variables were unaffected by CPAP withdrawal. The reduction in vigilance appeared to be associated with worsened hypoxemia and changed levels of tumor necrosis factor-alpha. Resumption of CPAP treatment had immediate benefits on sleep consolidation and subjective sleepiness.
Fast 3D face recognition based on normal map

This paper presents a 3D face recognition method aimed to biometric applications. The proposed method compares any two faces represented as 3D polygonal surfaces through their corresponding normal map, a bidimensional array which stores local curvature (mesh normals) as the pixel's RGB components of a color image. The recognition approach, based on the computation of a difference map resulting from the comparison of normal maps, is simple yet fast and accurate. A weighting mask, automatically generated for each subject using a set of expression variations, improves the robustness to a broad range of facial expressions. First results show the effectiveness of the method on a database of 3D faces featuring different genders, ages and expressions.
Layer chicken embryo survival to hatch when administered an in ovo vaccination of strain F Mycoplasma gallisepticum and locations of bacteria prevalence in the newly hatched chick1,2,3

ABSTRACT Mycoplasma gallisepticum (MG) is a bacterial pathogen that causes production losses in layer chickens. To combat MG, multiage layer facilities vaccinate pullets by either spray or eye‐drop vaccination. The objective in this study was to evaluate the use of in ovo vaccination as a potential alternative for MG vaccination. Layer embryos at 18 d of incubation were either not‐injected (control), or were hand‐injected with either commercial Marek's disease vaccine diluent alone or with a high, medium, low, or very low dosage of a live attenuated strain F (FMG) vaccine suspended in the commercial diluent. Hatch success and residual egg embryonic mortality were determined after 23 d of incubation. Six hatched chicks per treatment were swabbed for the detection of FMG at 4 different sites (trachea, mouth and esophagus, yolk sac membrane, and the lumen of the duodenal loop) via real‐time PCR. Embryos were found to be administered 106 CFU per dose in the high treatment, 104 CFU/dose in the medium treatment, 102 CFU/dose in the low treatment, and between 5.06 and 5.93 CFU/dose in the very low treatment. Hatch of embryonated eggs was decreased by the medium and high doses (P = 0.02). These embryos died while pipping. No FMG was detected in the control and diluent‐injected chicks. In the FMG treatments, FMG was found in all sites and dosages, with a greater number of positive chicks found in the higher FMG dosage treatments. These findings indicate the potential practicality of vaccinating layer embryos with FMG by in ovo injection based on the observed hatch success at lower dosages. Also, once injected into the amnion, the bacteria are present in the upper respiratory and gastrointestinal tracts as well the yolk sac membrane and the small intestine of hatchlings. Future research will need to ascertain the effects of FMG administered by in ovo injection on posthatch immunity and mortality.
Inhibition of Coronary Blood Flow by a Vascular Waterfall Mechanism

The mechanism whereby systole inhibits coronary blood flow was examined. A branch of the left coronary artery was maximally dilated with an adenosine infusion, and the pressure-flow relationship was obtained for beating and arrested states. The pressure-flow curve for the arrested state was linear from below 20 to beyond 200 mm Hg. The curve for the beating state was shifted toward higher pressures and in the range of pressures above peak ventricular pressure was linear and parallel to that for the arrested state. Below this range the curve for the beating state converged toward that for the arrested state and was convex to the pressure axis. These resultswere compared with a model of the coronary vasculature that consisted of numerous parallel channels, each responding to local intramyocardial pressure by forming vascular waterfalls. When intramyocardial pressure in the model was assigned values from zero at the epicardium to peak ventricular pressure at the endocardium, pressure-flow curves similar to the experimental ones resulted. Thus, we conclude that systole inhibits coronary perfusion by the formation of vascular waterfalls and that the intramyocardial pressures responsible for this inhibition do not significantly exceed peak ventricular pressure.