Miracle-dz/UniFAR-FTUs huggingface dataset:
Perceptions and practices of technology usage in English language curriculum implementation among instructors and students in Somaliland higher education institutions

This study aimed to investigate how instructors and students in Somaliland’s higher education institutions perceive and utilize technology in implementing the English language curriculum. The study involved 93 English language instructors and 377 students from both public and private universities. The instructors and students were selected using available sampling and proportionate stratified random sampling techniques respectively. Data was collected through a survey questionnaire and analyzed quantitatively using mean, standard deviation, one-sample test, independent samples t-test, and linear regression. The findings indicated that both instructors and students had low perceptions of the benefits of technology in English language teaching, and instructors had limited experience in implementing technology-supported curriculum. However, the study revealed a strong relationship between technology usage and successful curriculum implementation. Therefore, it was recommended that instructors and students receive training on educational technology awareness and practical application to enhance the English language curriculum implementation.
A Novel In Vitro Experimental System for the Evaluation of Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Cryopreserved Human Hepatocytes)

We report here a novel experimental system, cryopreserved MetMax human hepatocytes (MMHHs), for in vitro drug metabolism studies. MMHHs consist of cofactor-supplemented permeabilized cryopreserved human hepatocytes. The use procedures for MMHHs are significantly simplified from that for conventional cryopreserved human hepatocytes (CCHHs): 1) storage at −80°C instead of in liquid nitrogen and 2) usage directly after thawing without centrifugation and microscopic evaluation of cell density and viability and cell density adjustment. In this study, we compared MMHHs and CCHHs in CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP2J2, monoamine oxidase A, aldehyde oxidase, flavin-containing monooxygenase, UDP-glucuronyl transferase, SULT, N-acetyltransferase 1, and acetaminophen glutathione (GSH) conjugation activities based on liquid chromatography–tandem mass spectrometry quantification of substrate metabolism. MMHHs were prepared from CCHHs consisting of hepatocytes pooled from 10 individual donors. The drug metabolizing enzyme activities of both CCHHs and MMHHs were cell concentration and time dependent, with specific activities of MMHHs ranging from 27.2% (carboxylesterase 2) to 234.2% (acetaminophen GSH conjugation) of that for CCHHs. As observed in CCHHs, sequential oxidation and conjugation was observed in MMHHs for coumarin, 7-ethoxycoumarin, and acetaminophen. 7-Hydroxycoumarin conjugation results showed that metabolic pathways in MMHHs could be selected via the choice of cofactors, with glucuronidation but not sulfation observed in the presence of UDP-glucuronic acid and not 3-phosphoadenosine-5-phosphosulfate, and vice versa. Results with noncytotoxic and cytotoxic concentrations of acetaminophen showed that drug metabolism was compromised in CCHHs but not in MMHHs. Our results suggest that the MMHHs system represents a convenient and robust in vitro experimental system for the evaluation of drug metabolism.
Invariant Statistics and Coding of Natural Microimages

Fort Collins, CO, June, 1999. (Published on Web). Invariant Statistics and Coding of Natural Microimages Donald Geman1 and Alexey Koloydenko2 Abstract We search for universal characteristics of the microstructure of natural images. Our data consist of a very large set of 3 3 patches randomly extracted from indoor and outdoor grey level scenes. The patches are grouped into natural equivalence classes (\patterns") based on photometry, \complexity" and geometry. We analyze the stability of the pattern statistics over image sets, resolutions and grey scale distortions. Important aspects of the probability distribution of the patterns, e.g., the dominant masses, are stable in our experiments. We also compare the statistics of the natural patch world with those of arti cially generated images; the results are consistent with recently proposed \scaling laws" for the sizes of objects in natural images. These results suggest that well-chosen patch labels might serve as elementary features in pattern recognition and other imaging problems in which the ne structure of the grey level con gurations is not essential, and we sketch a computationally e cient way to carry this out using tree-structured vector quantization.
Temporal Course of 2014 Ebola Virus Disease (EVD) Outbreak in West Africa Elucidated through Morbidity and Mortality Data: A Tale of Three Countries

The explosive outbreak of Ebola virus disease (EVD) in West Africa in 2014 appeared to have lessened in 2015, but potentially continues be a global public health threat. A simple mathematical model, the Richards model, is utilized to gauge the temporal variability in the spread of the Ebola virus disease (EVD) in West Africa in terms of its reproduction number R and its temporal changes via detection of epidemic waves and turning points during the 2014 outbreaks in the three most severely affected countries; namely, Guinea, Liberia, and Sierra Leone. The results reveal multiple waves of infection in each of these three countries, of varying lengths from a little more than one week to more than one month. All three countries exhibit marginally fluctuating reproduction numbers during June-October before gradually declining. Although high mobility continues between neighboring populations of these countries across the borders, outbreak in these three countries exhibits decidedly different temporal patterns. Guinea had the most waves but maintained consistently low transmissibility and hence has the smallest number of reported cases. Liberia had highest level of transmission before October, but has remained low since, with no detectable wave after the New Year. Sierra Leone has gradually declining waves since October, but still generated detectable waves up to mid-March 2015, and hence has cumulated the largest number of cases—exceeding that of Guinea and Liberia combined. Analysis indicates that, despite massive amount of international relief and intervention efforts, the outbreak is persisting in these regions in waves, albeit more sparsely and at a much lower level since the beginning of 2015.
Self-care Ability and Demographic Characteristics among Older Adults in the Urban and Rural Areas of Miandoab, Iran

Objectives: Self-care helps older adults manage their health and stay independent by delaying disability. This study aimed to study the self-care ability and demographic characteristics of older adults in urban and rural areas of Miandoab. Design: This cross-sectional study was conducted in 2017, encompassing a total of 620 older adults aged 60 years and above. Participants: Eligible older adults were selected using stratified random sampling method from both urban and rural healthcare centers located in Miandoab, Iran. The data collection instruments comprised a demographic questionnaire and self-care ability. Data analysis was conducted using SPSS version 18 software employing t-tests and one-way analysis of variance. Results: The mean ± standard deviation of self-care was higher in the physical dimension of the older adults living in rural areas (80.64±0.81), males (90.69±1.00), married elderly (90.87±0.75), illiterate elderly (94.67±1.08), employed individuals (91.78±0.98), those with less than 65 years old (95.18±0.69), and old adults with an income level of more than 2 million (93.36±1.56). Moreover, a statistically significant difference was observed (P<0.05). Conclusions: Demographic factors such as the place of residence, marriage, economic sufficiency, and lifestyle influenced the level of self-care. The findings suggest providing measures to improve the quality of life of older adults. The members of the rural family physicians’ health team and healthcare providers in urban areas should play a more substantial role in training and improving self-care
Generation of the podocyte and tubular components of an amniote kidney: timing of specification and a role for Wnt signaling

Kidneys remove unwanted substances from the body and regulate the internal body environment. These functions are carried out by specialized cells (podocytes) that act as a filtration barrier between the internal milieu and the outside world, and by a series of tubules and ducts that process the filtrate and convey it to the outside. In the kidneys of amniote vertebrates, the filtration (podocyte) and tubular functions are tightly integrated into functional units called nephrons. The specification of the podocyte and tubular components of amniote nephrons is currently not well understood. The present study investigates podocyte and tubule differentiation in the avian mesonephric kidney, and presents several findings that refine our understanding of the initial events of nephron formation. First, well before the first morphological or molecular signs of nephron formation, mesonephric mesenchyme can be separated on the basis of morphology and the expression of the transcription factor Pod1 into dorsal and ventral components, which can independently differentiate in culture along tubule and podocyte pathways, respectively. Second, canonical Wnt signals, which are found in the nephric duct adjacent to the dorsal mesonephric mesenchyme and later in portions of the differentiating nephron, strongly inhibit podocyte but not tubule differentiation, suggesting that Wnt signaling plays an important role in the segmentation of the mesonephric mesenchyme into tubular and glomerular segments. The results are discussed in terms of their broader implications for models of nephron segmentation.
SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells

Abstract. Reversible phosphorylation plays an important role in pre-mRNA splicing in mammalian cells. Two kinases, SR protein-specific kinase (SRPK1) and Clk/Sty, have been shown to phosphorylate the SR family of splicing factors. We report here the cloning and characterization of SRPK2, which is highly related to SRPK1 in sequence, kinase activity, and substrate specificity. Random peptide selection for preferred phosphorylation sites revealed a stringent preference of SRPK2 for SR dipeptides, and the consensus derived may be used to predict potential phosphorylation sites in candidate arginine and serine-rich (RS) domain–containing proteins. Phosphorylation of an SR protein (ASF/SF2) by either SRPK1 or 2 enhanced its interaction with another RS domain–containing protein (U1 70K), and overexpression of either kinase induced specific redistribution of splicing factors in the nucleus. These observations likely reflect the function of the SRPK family of kinases in spliceosome assembly and in mediating the trafficking of splicing factors in mammalian cells. The biochemical and functional similarities between SRPK1 and 2, however, are in contrast to their differences in expression. SRPK1 is highly expressed in pancreas, whereas SRPK2 is highly expressed in brain, although both are coexpressed in other human tissues and in many experimental cell lines. Interestingly, SRPK2 also contains a proline-rich sequence at its NH2 terminus, and a recent study showed that this NH2-terminal sequence has the capacity to interact with a WW domain protein in vitro. Together, our studies suggest that different SRPK family members may be uniquely regulated and targeted, thereby contributing to splicing regulation in different tissues, during development, or in response to signaling.
Inelastic Compaction in High‐Porosity Limestone Monitored Using Acoustic Emissions

We performed a systematic investigation of mechanical compaction and strain localization in Saint‐Maximin limestone, a quartz‐rich, high‐porosity (37%) limestone from France. Our new data show that the presence of a significant proportion of secondary mineral (i.e., quartz) did not impact the mechanical strength of the limestone in both the brittle faulting and cataclastic flow regimes, but that the presence of water exerted a significant weakening effect. In contrast to previously published studies on deformation in limestones, inelastic compaction in Saint‐Maximin limestone was accompanied by abundant acoustic emission (AE) activity. The location of AE hypocenters during triaxial experiments revealed the presence of compaction localization. Two failure modes were identified in agreement with microstructural analysis and X‐ray computed tomography imaging: compactive shear bands developed at low confinement and complex diffuse compaction bands formed at higher confinement. Microstructural observations on deformed samples suggest that the recorded AE activity associated with inelastic compaction, unusual for a porous limestone, could have been due to microcracking at the quartz grain interfaces. Similar to published data on high‐porosity macroporous limestones, the crushing of calcite grains was the dominant micromechanism of inelastic compaction in Saint‐Maximin limestone. New P wave velocity data show that the effect of microcracking was dominant near the yield point and resulted in a decrease in P wave velocity, while porosity reduction resulted in a significant increase in P wave velocity beyond a few percent of plastic volumetric strain. These new data highlight the complex interplay between mineralogy, rock microstructure, and strain localization in porous rocks.
Gratitude Orientation Reduces Death Anxiety but Not Positive and Negative Affect

This study aims at investigating whether a gratitude induction procedure can reduce death anxiety and promote emotional well-being. Ninety Chinese undergraduate students were randomly assigned into one of three experimental conditions: gratitude, hassle, and neutral. In each condition, participants were instructed to spend 15–20 minutes to reflect on past events and to write up to five events of the designated category. Subsequently, they responded to measures of death anxiety and affect. Results showed that those in the gratitude condition reported much lower death anxiety than those in the neutral or the hassle group. However, gratitude had no effect on positive or negative affect. The findings suggest that the effect of gratitude may be specific to death anxiety, which does not occur in the context of the enhancement of overall emotional well-being.
Land use and water quality characterization of Boeuf Basin, LA

The three primary goals of this project were to establish the ambient background of water quality in the Lake Boeuf basin in southeast Louisiana; establish land use patterns in the basin and the relation to water quality; and develop a preliminary plan to improve water quality through the use of best management practices and wetland assimilation. Urban and agricultural acreage borders the basin and runoff from these lands forces loadings of nutrients into the adjacent canals where they become channelized and ultimately exit the Boeuf Basin into Lac des Allemandes. From September 2007 until February 2008, water sampling occurred monthly at twelve discrete locations throughout the study area. These samples were tested for NOx, PO4, Si, NH4, salinity, TSS, TN, and TP. Results of this data showed concentrations in the basin were not extraordinarily high. Sites located nearer to sugarcane acreages showed higher nutrient concentrations as compared to other sampling sites. Field data was compared to an existing dataset compiled by the Louisiana Department of Environmental Quality for use in establishing total maximum daily loads for the basin. Statistical analysis revealed significant decreases of PO4 and salinity concentrations from years 2000 through 2008. A yearly nutrient load estimate for the basin was established for NOx, NH4, TKN, TN, and TP. Using cited nutrient removal curves, it was determined that the available wetland acreage in Boeuf Basin could assimilate these loads achieving nearly 100% removal. Reductions in nutrient loads can be achieved by implementing best management practices in the adjacent agriculture. Other solutions include reducing direct flow from sugarcane field drainage ditches and diversion of this drainage through the wetlands allowing for assimilation.
Dynamic Causal Modeling of Spatiotemporal Integration of Phonological and Semantic Processes: An Electroencephalographic Study

Integration of phonological and lexicosemantic processes is essential for visual word recognition. Here we used dynamic causal modeling of event-related potentials, combined with group source reconstruction, to estimate how those processes translate into context-dependent modulation of effective connectivity within the temporal-frontal language network. Fifteen healthy human subjects performed a phoneme detection task in pseudo-words and a semantic categorization task in words. Cortical current densities revealed the sequential activation of temporal regions, from the occipital–temporal junction toward the anterior temporal lobe, before reaching the inferior frontal gyrus. A difference of activation between phonology and semantics was identified in the anterior temporal lobe within the 240–300 ms peristimulus time window. Dynamic causal modeling indicated this increase of activation of the anterior temporal lobe in the semantic condition as a consequence of an increase of forward connectivity from the posterior inferior temporal lobe to the anterior temporal lobe. In addition, fast activation of the inferior frontal region, which allowed a feedback control of frontal regions on the superior temporal and posterior inferior temporal cortices, was found to be likely. Our results precisely describe spatiotemporal network mechanisms occurring during integration of phonological and semantic processes. In particular, they support the hypothesis of multiple pathways within the temporal lobe for language processing, where frontal regions would exert a top-down control on temporal regions in the recruitment of the anterior temporal lobe for semantic processing.
Magnetically Induced Continuous CO2 Hydrogenation Using Composite Iron Carbide Nanoparticles of Exceptionally High Heating Power.

The use of magnetic nanoparticles to convert electromagnetic energy into heat is known to be a key strategy for numerous biomedical applications but is also an approach of growing interest in the field of catalysis. The heating efficiency of magnetic nanoparticles is limited by the poor magnetic properties of most of them. Here we show that the new generation of iron carbide nanoparticles of controlled size and with over 80 % crystalline Fe2.2 C leads to exceptional heating properties, which are much better than the heating properties of currently available nanoparticles. Associated to catalytic metals (Ni, Ru), iron carbide nanoparticles submitted to magnetic excitation very efficiently catalyze CO2 hydrogenation in a dedicated continuous-flow reactor. Hence, we demonstrate that the concept of magnetically induced heterogeneous catalysis can be successfully applied to methanation of CO2 and represents an approach of strategic interest in the context of intermittent energy storage and CO2 recovery.
Zircon Xenocrysts from Cenozoic Alkaline Basalts of the Ratanakiri Volcanic Province (Cambodia), Southeast Asia—Trace Element Geochemistry, O-Hf Isotopic Composition, U-Pb and (U-Th)/He Geochronology—Revelations into the Underlying Lithospheric Mantle

Zircon xenocrysts from alkali basalts in Ratanakiri Province, Cambodia represent a unique low-Hf zircon within a 12,000 km long Indo-Pacific megacryst zone. Colorless, yellow, brown, and red crystals ({100}, {101}, subordinate {211}, {1103}), with hopper growth and corrosion features range up to 20 cm in size. Zircon chemistry indicates juvenile, Zr-saturated, mantle-derived alkaline melt (Hf 0.6–0.7 wt %, Y <0.2 wt %, U + Th + REE (Rare-Earth Elements) < 600 ppm, Zr/Hf 66–92, Eu/Eu*N ~1, positive Ce/Ce*N, HREE (Heavy REE) enrichment). Incompatible element depletion with increasing Yb/SmN from core to rim at ~ constant Hf suggests single stage growth. Ti-in-zircon temperatures (~570–740 °C) are lower than predicted by crystal morphology (800–900 °C) and decrease from core to rim (ΔT = 10–50 °C). The δ18O values (4.88 to 5.01‰ VSMOW (Vienna Standard Mean Ocean Water)) are relatively low for xenocrysts from the zircon Indo-Pacific zone (ZIP). The 176Hf/177Hf values (+ εHf 4.5–10.2) give TDepleted Mantle model source ages of 260–462 Ma and TCrustal ages of 391–754 Ma. The source magmas reflect variably depleted lithospheric mantle with little supracrustal input. Zircon U-Pb (0.88–1.56 Ma) and (U-Th)/He (0.86–1.02 Ma) ages are older than host basalt ages (~0.7 Ma), which suggests limited residence before transport. Zircon genesis suggests Zr-saturated, Al-undersaturated, carbonatitic-influenced, low-degree partial melting (<1%) of peridotitic mantle at ~60 km beneath the Indochina terrane.
Custom-Fitted EVA Mouthguards: what is the ideal thickness? a dynamic finite element impact study.

BACKGROUND/AIM The aim of this study was to evaluate the tooth stresses and strains, shock absorption, and displacement during impact of custom-fitted mouthguards with different thicknesses. METHODS Six bar-shaped specimens of the EVA were made and subjected to tensile test for elastic modulus assessment. Two-dimensional plane-strain models of a human maxillary central incisor, periodontal ligament, bone support, soft tissue, and mouthguard (MTG) were created. The mouthguards were modeled in five different thicknesses (2, 3, 4, 5, and 6 mm). One model was created without mouthguard. A nonlinear dynamic impact analysis was performed in which a rigid object hit the model at 1 m s(-1). Strain and stress (von Mises and Critical modified von Mises) distributions were evaluated, and the displacement of the mouthguard with respect to the tooth was calculated. RESULTS The mean [SD] for the EVA elastic modulus was 18.075 [0.457] MPa. The model without mouthguard showed the highest stress values at the enamel and dentin structures in the tooth crown during the impact. For the MTG models, the location of the stress concentrations changed to the root, regardless of the MTG thickness, but maximum stresses in the enamel and dentin were lower compared with the model without MTG. Increasing the mouthguard thickness did not notably decrease the stress-strain values. CONCLUSION It was concluded that the use of a mouthguard promoted lower stresses and strains in teeth during an impact with a rigid object. There was no substantial difference in peak stresses and strains and in shock absorption among the different mouthguard thicknesses.
THE SRI MARCH 2000 HUB-5 CONVERSATIONAL SPEECH TRANSCRIPTION SYSTEM

We describe SRI’s large vocabulary conversational speech r ecognition system as used in the March 2000 NIST Hub-5E evaluation. The system performs four recognition passes: (1) bigram recognition with phone-loop-adapted, within-word triphone acoustic models, (2) lattice generation with transcription-mod e-adapted models, (3) trigram lattice recognition with adapted cross -word triphone models, and (4) N-best rescoring and reranking with various additional knowledge sources. The system incorporates two new kinds of acoustic model: triphone models conditioned on speaking rate, and an explicit joint model of within-word phone durations. We also obtained an unusually large improvement from modeling crossword pronunciation variants in “multiword” vocabulary items. The language model (LM) was enhanced with an “anti-LM” representing acoustically confusable word sequences. Finally, we applied a generalized ROVER algorithm to combine the N-best hypotheses from several systems based on different acoustic models.