Miracle-dz/UniFAR-FTUs huggingface dataset:
Familial patterns of risk in very late-onset Alzheimer disease.

BACKGROUND The incidence of Alzheimer disease (AD) peaks after 85 years of age. Although genetic factors are implicated in AD with substantially earlier onset, the familial characteristics of high-incidence very late-onset AD (VLOAD, defined here as AD with onset age >/=85 years) remain unknown. METHODS We collected information pertaining to the cognitive status and demographics of 809 parents and siblings of 144 VLOAD probands, 4235 parents and siblings of 793 earlier-onset AD probands, and 7646 parents and siblings of 1493 nondemented elderly probands. Cumulative risks and 5-year interval-specific hazard rate ratios were calculated for AD in relatives of the 2 AD proband groups and relatives of the nondemented elderly group. RESULTS The cumulative risk for AD in the relatives of VLOAD probands was significantly different than that in the relatives of earlier-onset AD probands (P<.001), but not in the relatives of nondemented elderly probands. Also, the relatives of earlier-onset AD probands had hazard rate ratios ranging from 19.7 in those aged 50 to 54 years to 1.2 in those aged 90 to 94 years. Rates successively dropped as age intervals increased. CONCLUSIONS At least through the middle of the ninth decade of life, relatives of VLOAD probands have a lower risk for AD than those of earlier-onset AD probands. In addition, the relatively increased risk of relatives of earlier-onset AD probands is highest at younger ages and diminishes with increasing age. In counseling family members of patients with AD concerned about their own risk, the onset age of the patient and the age of the concerned relative should be considered. Very late-onset AD may be a good target for investigating environmental factors associated with AD.
A Theory of Value Distribution in Social Exchange Networks

This paper considers the value distribution in an arbitrary exogenously given social exchange network, where any two linked nodes can potentially generate one unit of surplus. A value distribution solution is a mapping that associates a value distribution outcome with each social exchange network. We impose a consistency condition on the value distribution solution. We find that there is a unique value distribution solution that satisfies the consistency condition. As regards some simple networks that are frequently analyzed in the literature, the theoretical prediction based on our solution fits the experimental data very well. Finally, a strategic procedure is proposed to support the solution.
Rate-Power-Interference Optimization in Underlay OFDMA CRNs with Imperfect CSI

Achieving higher transmission rate while reducing transmission power and induced interference on neighboring receivers is deemed necessary for the advancement of future generation networks and is particularly challenging, since these directions could be conflicting in nature. This letter adopts a multiobjective optimization (MOOP) approach to settle the tradeoffs between these three conflicting objectives in orthogonal frequency-division multiple access-based cognitive radio networks. Besides, unlike most of the work in the literature that studied the imperfect channel side information (CSI) of the link between the secondary transmitter and the primary receiver to evaluate ergodic capacity, the MOOP formulation considers the imperfect CSI of cross links between secondary and primary, which makes the formulated MOOP difficult to solve, since traditional water-filling-in-time solution does not directly apply to this problem. Hence, to solve this MOOP, a dummy power allocation is first used, and then obtained MOOP is solved by using a weighted Tchebycheff method.
The TetR Family of Transcriptional Repressors

SUMMARY We have developed a general profile for the proteins of the TetR family of repressors. The stretch that best defines the profile of this family is made up of 47 amino acid residues that correspond to the helix-turn-helix DNA binding motif and adjacent regions in the three-dimensional structures of TetR, QacR, CprB, and EthR, four family members for which the function and three-dimensional structure are known. We have detected a set of 2,353 nonredundant proteins belonging to this family by screening genome and protein databases with the TetR profile. Proteins of the TetR family have been found in 115 genera of gram-positive, α-, β-, and γ-proteobacteria, cyanobacteria, and archaea. The set of genes they regulate is known for 85 out of the 2,353 members of the family. These proteins are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which the family member is involved can be simple, as in TetR (i.e., TetR bound to the target operator represses tetA transcription and is released in the presence of tetracycline), or more complex, involving a series of regulatory cascades in which either the expression of the TetR family member is modulated by another regulator or the TetR family member triggers a cell response to react to environmental insults. Based on what has been learned from the cocrystals of TetR and QacR with their target operators and from their three-dimensional structures in the absence and in the presence of ligands, and based on multialignment analyses of the conserved stretch of 47 amino acids in the 2,353 TetR family members, two groups of residues have been identified. One group includes highly conserved positions involved in the proper orientation of the helix-turn-helix motif and hence seems to play a structural role. The other set of less conserved residues are involved in establishing contacts with the phosphate backbone and target bases in the operator. Information related to the TetR family of regulators has been updated in a database that can be accessed at www.bactregulators. org .
Religious competence as cultural competence

Definitions of cultural competence often refer to the need to be aware and attentive to the religious and spiritual needs and orientations of patients. However, the institution of psychiatry maintains an ambivalent attitude to the incorporation of religion and spirituality into psychiatric practice. This is despite the fact that many patients, especially those from underserved and underprivileged minority backgrounds, are devotedly religious and find much solace and support in their religiosity. I use the case of mental health of African Americans as an extended example to support the argument that psychiatric services must become more closely attuned to religious matters. I suggest ways in which this can be achieved. Attention to religion can aid in the development of culturally competent and accessible services, which in turn, may increase engagement and service satisfaction among religious populations.
Further steps toward direct magnetic resonance (MR) imaging detection of neural action currents: Optimization of MR sensitivity to transient and weak currents in a conductor

The characteristics of an MRI technique that could be used for direct detection of neuronal activity are investigated. It was shown that magnitude imaging using echo planar imaging can detect transient local currents. The sensitivity of this method was thoroughly investigated. A partial k‐space EPI acquisition with homodyne reconstruction was found to increase the signal change. A unique sensitivity to the position of the current pulse within the imaging sequence was demonstrated with the greatest signal change occurring when the current pulse coincides with the acquisition of the center lines of k‐space. The signal change was shown to be highly sensitive to the spatial position of the current conductor relative to the voxel. Furthermore, with the use of optimization of spatial and temporal placement of the current pulse, the level of signal change obtained at this lower limit of current detectability was considerably magnified. It was possible to detect a current of 1.7 μA applied for 20 ms with an imaging time of 1.8 min. The level of sensitivity observed in our study brings us closer to that theoretically required for the detection of action currents in nerves. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.
Propagation of medium frequency (1–4 MHz) auroral radio waves to the ground via the Z‐mode radio window

Recent ground-based observations of auroral radio waves have identified narrowband emissions near 2 and 3 times the lower ionospheric electron cyclotron frequency (fce) known as auroral roars. In this paper the propagation of these waves in the auroral ionosphere is investigated by means of a ray-tracing technique. We model one particular scenario in which a large-scale (tens of kilometers) horizontal density structure, based on density structures observed with the Sondrestrom radar at times of auroral roar emissions, plays a crucial role in both guiding the waves to the ground and enabling mode conversion. The location and the mode characteristics of the initial waves are determined on the basis of local stability properties, which suggests that Z-mode wave excitation is favored near 2fce. However, since Z-mode cannot propagate to the ground they must first undergo a mode conversion to one of the free-space modes (X and O). It is found that for a narrow range of frequencies and initial wave phase angles the trapped Z mode can be converted to O mode via the Ellis radio window. This finding is consistent with the fact that auroral roar emissions are nearly 100% O-mode polarized. However, it is important to note that the evaluation of the damping of the Z-mode waves along the ray path is not considered within the context of this preliminary study and will be critical for eventually determining the exact physical scenario of the auroral roar generation mechanism.
Proton-Induced Fission Cross Section Calculation with the LANL Codes CEM2K+GEM2 and LAQGSM+GEM2

The improved Cascade-Exciton Model code CEM2k and the Los Alamos version of the Quark-Gluon String Model code LAQGSM, previously merged with the Generalized Evaporation Model code of Furihata (GEM2) were further modified to provide reliable proton-induced fission cross sections for applications. By adjusting two parameters in GEM2 for each measured reaction, we were able to describe very well with CEM2k+GEM2 and LAQGSM+GEM2 all available experimental fission cross sections induced by protons with energies from 20 MeV to 10 GeV both for subactinide and actinide targets. We also successfully tested our approach on several reactions induced by neutrons, pions, and photons.
Comparison of In Vitro Metabolism of Ticlopidine by Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4

A recent X-ray crystal structure of a rabbit cytochrome P450 2B4 (CYP2B4)-ticlopidine complex indicated that the compound could be modeled with either the thiophene or chlorophenyl group oriented toward the heme prosthetic group. Subsequent NMR relaxation and molecular docking studies suggested that orientation with the chlorophenyl ring closer to the heme was the preferred one. To evaluate the predictive value of these findings, the oxidation of ticlopidine by reconstituted CYP2B4 was studied and compared with CYP2B6, in which the thiophene portion of the molecule likely orients toward the heme. In vitro incubation of ticlopidine with both enzymes yielded the same set of metabolites: 7-hydroxyticlopidine (M1), 2-oxoticlopidine (M2), 5-(2-chlorobenzyl)thieno[3,2-c]pyridin-5-ium metabolite (M3), 5-(2-chlorobenzyl)thieno[3,2-c]pyridin-5-ium metabolite (M4), ticlopidine N-oxide (M5), and ticlopidine S-oxide dimer, a dimerization product of ticlopidine S-oxide (M6). The rates of metabolite formation deviated markedly from linearity with time, consistent with the known inactivation of CYP2B6 by ticlopidine. Fitting to a first-order equation yielded similar rate constants (kobs) for both enzymes. However, the amplitude (Rmax) of M1 and M6 formation was 4 to 5 times higher for CYP2B6 than CYP2B4, indicating a greater residence time of ticlopidine with its thiophene ring closer to heme in CYP2B6. In contrast, CYP2B4 formed M4 and M5 in more abundance than CYP2B6, indicating an alternate orientation. Overall, the results suggest that the preferential orientation of ticlopidine in the active site of CYP2B4 predicted by X-ray crystallography and NMR studies is unproductive and that ticlopidine likely reorients within CYP2B4 to a more productive mode.
Citations of Most Often Cited Economists: Do Scholarly Books Matter More than Quality Journals?

This paper empirically investigates the determinants of citations based on the publication of the top 100 most often cited economists. The effects of publication age and author fame on subsequent citations are found to be positive and significant. Citations are also significantly affected by popular subfields in economics. However, journal quality measures, such as impact factors, download statistics and top-4 elite journals, have insignificant effects on citations. In contrast, the citation effect of scholarly books is positive and significant, and its impact is even greater than those of journal quality measures.
Misleading worm signature generators using deliberate noise injection

Several syntactic-based automatic worm signature generators, e.g., Polygraph, have recently been proposed. These systems typically assume that a set of suspicious flows are provided by a flow classifier, e.g., a honeynet or an intrusion detection system, that often introduces "noise" due to difficulties and imprecision inflow classification. The algorithms for extracting the worm signatures from the flow data are designed to cope with the noise. It has been reported that these systems can handle a fairly high noise level, e.g., 80% for Polygraph. In this paper, we show that if noise is introduced deliberately to mislead a worm signature generator, a much lower noise level, e.g., 50%, can already prevent the system from reliably generating useful worm signatures. Using Polygraph as a case study, we describe a new and general class of attacks whereby a worm can combine polymorphism and misleading behavior to intentionally pollute the dataset of suspicious flows during its propagation and successfully mislead the automatic signature generation process. This study suggests that unless an accurate and robust flow classification process is in place, automatic syntactic-based signature generators are vulnerable to such noise injection attacks
The Embodied Nature of Autistic Learning: Implications for Physical Education

Abstract Autism spectrum disorder (ASD) and learning difficulties are difficult to separate in clinic manifestations and diagnoses. By taking learning as being-in-the-world, this article considers the embodied nature of autistic learning and urges its importance for understanding the phenomenological core of ASD. We begin by arguing that three mainstream contemporary ASD theories are inherently limited in offering an adequate account of autistic learning due to the disembodied ontology inscribed within them. Then, we provide an understanding of learning guided by the subjective dynamics of experience. Instead of having a disembodied and individualistic point of view, we suggest that autistic learning has an embodied nature. The “inappropriate” or “abnormal” affections and behaviors in the autistic experience of learning may actually be inherently meaningful for individuals with ASD. They strive to make sense of some basic disturbances and re-establish some form of coherence with the world, though this may only be possible in the form of delusions or autistic withdrawals. Finally, we explore the relationship between autistic learning and physical education and suggest in particular how spontaneous imitation can boost the development of children with ASD. We conclude that the application of implicit learning strategies in playful settings and the reduction of explicit strategies based upon intellectual reasoning rather than bodily reciprocity should be encouraged in the process of autistic learning.
Assessment of physical function in adults with Prader-Willi syndrome

Purpose. To evaluate implementation of at test battery for assessing physical function in adults with Prader-Willi syndrome (PWS). Method. Forty-three adults with PWS, 20 men and 23 women, mean age 29 ± 9 years. Body mass index (BMI) and body composition were measured. A test battery a.m. Guralnik for standing balance, 2.4 m and 10 m walk and repeated rising from a chair was scored and evaluated. Results. Mean BMI was 29.4 ± 9.1 kg/m2, body fat mass (FM) 26.0 ± 16.1 kg. The adults with PWS managed the test battery well, and high scores were achieved for standing balance and 2.4 m walk. In contrast, only 13 managed maximum score in the repeated rising from a chair and 31 to walk 10 m for 6 s or faster. Significant correlations were seen between 2.4 m walk and FM ( p = 0.041) and between 10 m walk and BMI ( p = 0.001) and FM ( p = 0.019). Conclusions. Repeated rising from a chair and 10 m walk are useful assessments in clinical practice to identify adults with PWS with reduced physical function. Reduced performance was related to higher BMI and FM emphasising the importance of efforts to keep normal body weight and body composition in adults with PWS. These measures might be useful in monitoring effects of intervention.
Evaluation of BRDF Archetypes for Representing Surface Reflectance Anisotropy Using MODIS BRDF Data

Bidirectional reflectance distribution function (BRDF) archetypes extracted from the Moderate Resolution Imaging Spectroradiometer (MODIS) BRDF/Albedo product over the global Earth Observing System Land Validation Core Sites can be used to simplify BRDF models. The present study attempts to evaluate the representativeness of BRDF archetypes for surface reflectance anisotropy. Five-year forward-modeled MODIS multi-angular reflectance (MCD-ref) and aditional actual MODIS multi-angular observations (MCD-obs) in four growing periods in 2008 over three tiles were taken as validation data. First, BRDF archetypes in the principal plane were qualitatively compared with the time-series MODIS BRDF product of randomly sampled pixels. Secondly, BRDF archetypes were used to fit MCD-ref, and the average root-mean-squared errors (RMSEs) over each tile were examined for these five years. Finally, both BRDF archetypes and the MODIS BRDF were used to fit MCD-obs, and the histograms of the fit-RMSEs were compared. The consistency of the directional reflectance between the BRDF archetypes and MODIS BRDFs in nadir-view, hotspot and entire viewing hemisphere at 30° and 50° solar geometries were also examined. The results confirm that BRDF archetypes are representative of surface reflectance anisotropy for available snow-free MODIS data.
The leaves of Diospyros kaki exert beneficial effects on a benzalkonium chloride–induced murine dry eye model

Purpose In this study, the beneficial effects of the oral administration of ethanol extract of Diospyros kaki (EEDK) were tested on a mouse dry eye model induced by benzalkonium chloride (BAC). Methods A solution of 0.2% BAC was administered topically to mouse eyes for 14 days, twice daily, to induce dry eye. Various concentrations of EEDK were administrated daily by oral gavage for 14 days after BAC treatment. Preservative-free eye drops were instilled in the positive-control group. The tear secretion volume (Schirmer’s test), tear break-up time (BUT), and fluorescein score were measured on the ocular surface. BAC-induced corneal damage was tested with hematoxylin-eosin staining. Moreover, apoptotic cell death in the corneal epithelial layer was investigated with terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining. The protein expression level of interleukin-1alpha (IL-1α), IL-1β, IL-6, tumor necrosis factor- alpha (TNF-α), and monocyte chemotactic protein-1 (MCP-1) was determined with western blot analysis. Furthermore, squamous metaplasia in the corneal epithelial layer was detected with immunofluorescent staining for cytokeratine-10. The cellular proliferation in the cornea was examined with immunohistochemical staining for Ki-67. Results EEDK treatment resulted in prolonged BUT, decreased fluorescein score, increased tear volume, and smoother epithelial cells compared with BAC treatment alone in the cornea. Moreover, EEDK treatment inhibited the inflammatory response and corneal epithelial cell death in a BAC-induced murine dry eye model, and changes in squamous cells were inhibited. Proliferative activity in the corneal epithelium cells was improved with EEDK. Conclusions EEDK could be a potential therapeutic agent in the clinical treatment of dry eye.
Implications of “Too Good to Be True” for Replication, Theoretical Claims, and Experimental Design: An Example Using Prominent Studies of Racial Bias

In response to concerns about the validity of empirical findings in psychology, some scientists use replication studies as a way to validate good science and to identify poor science. Such efforts are resource intensive and are sometimes controversial (with accusations of researcher incompetence) when a replication fails to show a previous result. An alternative approach is to examine the statistical properties of the reported literature to identify some cases of poor science. This review discusses some details of this process for prominent findings about racial bias, where a set of studies seems “too good to be true. ” This kind of analysis is based on the original studies, so it avoids criticism from the original authors about the validity of replication studies. The analysis is also much easier to perform than a new empirical study. A variation of the analysis can also be used to explore whether it makes sense to run a replication study. As demonstrated here, there are situations where the existing data suggest that a direct replication of a set of studies is not worth the effort. Such a conclusion should motivate scientists to generate alternative experimental designs that better test theoretical ideas.
Random Access Protocols for Collaborative Spectrum Sensing in Multi-Band Cognitive Radio Networks

In this paper, collaborative sensing and distributed detection are addressed in the context of multi-band cognitive radios. In a cognitive radio network, all the nodes may sense the spectrum simultaneously. They should then exchange their sensing results in order to improve the reliability of the detection. This exchange of information has to be done effectively to improve the bandwidth efficiency of the network. We propose a generalized medium access control (MAC) signaling protocol based on random access and study its performance through a thorough theoretical analysis. We begin with a nonadaptive protocol with fixed parameters. The numerical results obtained from analysis reveals that the fixed parameter protocol is not robust to the variation of the network conditions which, in general, are unknown a priori. We thus extend the proposed protocol to an adaptive one. Analysis of this adaptive protocol reveals its much superior performance. Our analysis covers a wide range of network conditions, including the case where some spectral activities may be hidden from a few of cognitive nodes and the case when a cognitive node senses only a subset of spectral bands. All theoretical results are corroborated through computer simulations.