Miracle-dz/UniFAR-FTUs huggingface dataset:
Distinct neural systems subserve person and object knowledge

Studies using functional neuroimaging and patient populations have demonstrated that distinct brain regions subserve semantic knowledge for different classes of inanimate objects (e.g., tools, musical instruments, and houses). What this work has yet to consider, however, is how conceptual knowledge about people may be organized in the brain. In particular, is there a distinct functional neuroanatomy associated with person knowledge? By using event-related functional magnetic resonance imaging (fMRI), we measured neural activity while participants made semantic judgments about people or objects. A unique pattern of brain activity was associated with person judgments and included brain regions previously implicated in other aspects of social-cognitive functioning: medial prefrontal cortex, superior temporal cortex, intraparietal sulcus, and fusiform gyrus. These regions were generally marked by relatively little change from baseline brain activity for person judgments along with significant deactivations for object judgments. Together, these findings support the notion that person knowledge may be functionally dissociable from other classes of semantic knowledge within the brain.
Anthropogenic Disturbance Can Determine the Magnitude of Opportunistic Species Responses on Marine Urban Infrastructures

Background Coastal landscapes are being transformed as a consequence of the increasing demand for infrastructures to sustain residential, commercial and tourist activities. Thus, intertidal and shallow marine habitats are largely being replaced by a variety of artificial substrata (e.g. breakwaters, seawalls, jetties). Understanding the ecological functioning of these artificial habitats is key to planning their design and management, in order to minimise their impacts and to improve their potential to contribute to marine biodiversity and ecosystem functioning. Nonetheless, little effort has been made to assess the role of human disturbances in shaping the structure of assemblages on marine artificial infrastructures. We tested the hypothesis that some negative impacts associated with the expansion of opportunistic and invasive species on urban infrastructures can be related to the severe human disturbances that are typical of these environments, such as those from maintenance and renovation works. Methodology/Principal Findings Maintenance caused a marked decrease in the cover of dominant space occupiers, such as mussels and oysters, and a significant enhancement of opportunistic and invasive forms, such as biofilm and macroalgae. These effects were particularly pronounced on sheltered substrata compared to exposed substrata. Experimental application of the disturbance in winter reduced the magnitude of the impacts compared to application in spring or summer. We use these results to identify possible management strategies to inform the improvement of the ecological value of artificial marine infrastructures. Conclusions/Significance We demonstrate that some of the impacts of globally expanding marine urban infrastructures, such as those related to the spread of opportunistic, and invasive species could be mitigated through ecologically-driven planning and management of long-term maintenance of these structures. Impact mitigation is a possible outcome of policies that consider the ecological features of built infrastructures and the fundamental value of controlling biodiversity in marine urban systems.
Taming Adversarial Domain Transfer with Structural Constraints for Image Enhancement

The goal of this work is to clarify images of traffic scenes that are degraded by natural causes such as fog, rain and limited visibility during the night. For these applications, it is next to impossible to get pixel perfect pairs of the same scene, with and without the degrading conditions. This makes it unsuitable for conventional supervised learning approaches. It is however easy to collect a dataset of unpaired images of the scenes in a perfect and in a degraded condition. To enhance the images taken in a poor visibility condition, domain transfer models can be trained to transform an image from the degraded to the clear domain. A well-known concept for unsupervised domain transfer are cycle consistent generative adversarial models. Unfortunately, the resulting generators often change the structure of the scene. This causes an undesirable change in the semantics of the traffic situation. We propose three ways to cope with this problem depending on the type of degradation: forcing the same perception in both domains, forcing the same edges in both domains or guiding the generator to produce semantically sound transformations.
Tryptophan Catabolism Restricts IFN-γ–Expressing Neutrophils and Clostridium difficile Immunopathology

The interplay between Clostridium difficile and the host’s metabolome is believed to influence the severity of infection. However, the mechanism for this phenomenon remains unclear. In this study, we model one of these metabolic pathways by focusing on tryptophan metabolism in the host. We found that inhibition of tryptophan catabolism in IDO1-knockout mice led to increased mucosal destruction, cecal hemorrhage, and increased production of IFN-γ in response to C. difficile infection, but no significant change in mucosal effector or regulatory T cell numbers or IL-10 mRNA expression. The increased immunopathology in infected IDO1-knockout mice was associated with a lower C. difficile burden and an increased percentage of IFN-γ–expressing neutrophils. We further demonstrated the ability of kynurenine to induce apoptosis in bone marrow–derived neutrophils, whereas the presence of tryptophan reversed this effect, providing a possible mechanism for the increased neutrophil accumulation in IDO1−/− mice. We conclude that C. difficile induces tryptophan catabolism in cecal lamina propria cells, which restricts C. difficile–associated immunopathology and the accumulation of IFN-γ–expressing neutrophils. This might represent a self-regulatory mechanism for neutrophils, via the IFN-γ–IDO1 pathway, to restrict their own accumulation during infection. These findings have important clinical implications because IDO inhibitors are used to treat cancer in clinical trials (in patients particularly susceptible to getting C. difficile infection), and treatment with IDO1 inhibitors may exacerbate the severity of C. difficile colitis.
Microaerophilic growth and induction of the photosynthetic reaction center in Rhodopseudomonas viridis

Rhodopseudomonas viridis was grown in liquid culture at 30 degrees C anaerobically in light (generation time, 13 h) and under microaerophilic growth conditions in the dark (generation time, 24 h). The bacterium could be cloned at the same temperature anaerobically in light (1 week) and aerobically in the dark (3 to 4 weeks) if oxygen was limited to 0.1%. Oxygen could not be replaced by dimethyl sulfoxide, potassium nitrate, or sodium nitrite as a terminal electron acceptor. No growth was observed anaerobically in darkness or in the light when air was present. A variety of additional carbon sources were used to supplement the standard succinate medium, but enhanced stationary-phase cell density was observed only with glucose. Conditions for induction of the photosynthetic reaction center upon the change from microaerophilic to phototrophic growth conditions were investigated and optimized for a mutant functionally defective in phototrophic growth. R. viridis consumed about 20-fold its cell volume of oxygen per hour during respiration. The MICs of ampicillin, kanamycin, streptomycin, tetracycline, 1-methyl-3-nitro-1-nitrosoguanidine, and terbutryn were determined.
“At our age, we would like to do things the way we want:” a qualitative study of adolescent HIV testing services in Kenya

Objectives: Adolescents in Africa have low HIV testing rates. Better understanding of adolescent, provider, and caregiver experiences in high-burden countries such as Kenya could improve adolescent HIV testing programs. Design: We conducted 16 qualitative interviews with HIV-positive and HIV-negative adolescents (13–18 years) and six focus group discussions with Healthcare workers (HCWs) and caregivers of adolescents in Nairobi, Kenya. Methods: Semi-structured interviews and focus groups were recorded and transcribed. Analysis employed a modified constant comparative approach to triangulate findings and identify themes influencing testing experiences and practices. Results: All groups identified that supportive interactions during testing were essential to the adolescent's positive testing experience. HCWs were a primary source of support during testing. HCWs who acted respectful and informed helped adolescents accept results, link to care, or return for repeat testing, whereas HCWs who acted dismissive or judgmental discouraged adolescent testing. Caregivers universally supported adolescent testing, including testing with the adolescent to demonstrate support. Caregivers relied on HCWs to inform and encourage adolescents. Although peers played less significant roles during testing, all groups agreed that school-based outreach could increase peer demand and counteract stigma. All groups recognized tensions around adolescent autonomy in the absence of clear consent guidelines. Adolescents valued support people during testing but wanted autonomy over testing and disclosure decisions. HCWs felt pressured to defer consent to caregivers. Caregivers wanted to know results regardless of adolescents’ wishes. Conclusion: Findings indicate that strengthening HCW, caregiver, and peer capacities to support adolescents while respecting their autonomy may facilitate attaining ‘90-90-90’ targets for adolescents.
XMM-Newton Observation of IC 310 in the Outer Region of the Perseus Cluster of Galaxies

We present results from an XMM-Newton observation of the head-tail radio galaxy IC 310 located in the southwest region of the Perseus cluster. The spectrum is well fitted by an absorbed power-law model with a photon index of 2.50 ±0.02 without significant absorption excess. The X-ray image shows a point-like emission at IC 310 without any sign of a structure correlated with the radio halo tail. The temperature of the intracluster medium surrounding IC 310 declines as a function of distance from the cluster center, from kT ∼6keV in the northeast corner of the field of view to about 3keV in the southwest region. Although we do not find any sharp edges in the surface brightness profile, a brightness excess of about 20% over a smooth β model is seen. The temperature also rises by about 10% in the same region. This indicates that the IC 310 region is a subcluster probably infalling into the Perseus cluster, and the gas in front of IC 310 towards the Perseus cluster is likely to be compressed by the large-scale motion, which supports the view that the IC 310 system is undergoing a merger.
Use of an Electronic Medication Administration Record (eMAR) for Surveillance of Medication Omissions: Results of a One Year Study of Antimicrobials in the Inpatient Setting

Introduction Medication administration omissions (MAO) are usually considered medication errors but not all MAO are clinically relevant. We determined the frequency of clinically relevant MAO of antimicrobial drugs in adult hospitals in Calgary, Alberta, Canada based on electronic medication administration record (eMAR). Methods We examined 2011 data from eMAR records on medical wards and developed a reproducible assessment scheme to categorize and determine clinical relevance of MAO. We applied this scheme to records from 2012 in a retrospective cohort study to quantify clinically relevant MAO. Significant predictors of clinically relevant MAO were identified. Results A total of 294,718 dose records were assessed of which 10,282 (3.49%) were for doses not administered. Among these 4903 (1.66% of total); 47.68% of MAO were considered clinically relevant. Significant positive predictors of clinically relevant MAO included inhaled (OR 4.90, 95% CI 3.54-6.94) and liquid oral (OR 1.32, 95% CI 1.18-1.47) route of medication compared to solid oral and irregular dose schedules. Evening nursing shift compared to night shift (OR 0.77 95% CI 0.70-0.85) and parenteral (OR 0.50, 95% CI 0.46-0.54) were negative predictors, The commonest reasons for relevant MAO were patient preference, unspecified reason, administration access issues, drug not available or patient condition. Conclusion Assessment of MAO by review of computer records provides a greater scope and sample size than directly observed medication administration assessments without “observer” effect. We found that MAO of antimicrobials in inpatients were uncommon but were seen more frequently with orally administered antimicrobials which may have significance to antimicrobial stewardship initiatives.
D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells.

BACKGROUND & AIMS 5-Hydroxytryptamine (5-HT) is released from enterochromaffin cells and activates neural reflex programs regulating motility and secretion. Although sugars are reported to release 5-HT in vivo, it is unclear whether they act directly on enterochromaffin cells or indirectly through an intermediary messenger. The aim was to determine if D-glucose is a stimulus for 5-HT release. METHODS Human BON cells, derived from enterochromaffin cells, were treated with D-glucose, galactose, and the nonmetabolizable methyl alpha-D-glucopyranoside, or with fructose. RESULTS Reverse-transcription polymerase chain reaction together with Western blot analysis revealed an SGLT-like protein. D-glucose caused a concentration-dependent increase in 5-HT release, which was mimicked by methyl alpha-D-glucopyranoside and galactose but not fructose. D-glucose-stimulated 5-HT release was significantly reduced by phloridzin. Concentrations of mannitol below 75 mmol/L were ineffective in releasing 5-HT. Brefeldin A abolished forskolin-stimulated 5-HT release without affecting basal or constitutive release. CONCLUSIONS The results show that high concentrations of metabolizable and nonmetabolizable hexoses activate signal transduction pathways, leading to release of 5-HT. These findings imply a role for enterochromaffin cells as "glucose sensors" during ingestion of a meal.
Radiolabeled Cholinesterase Substrates: In Vitro Methods for Determining Structure-Activity Relationships and Identification of a Positron Emission Tomography Radiopharmaceutical for In Vivo Measurement of Butyrylcholinesterase Activity

There is currently great interest in developing radiolabeled substrates for acetylcholinesterase and butyrylcholinesterase that would be useful in the in vivo imaging of patients with Alzheimer's disease. Using a simple in vitro spectrophotometric assay for determination of enzymatic cleavage rates, the structure-activity relationship for a short series of 1-methyl-4-piperidinyl esters was investigated. Relative enzymatic hydrolysis rates for the well-characterized 1-methyl-4-piperidinyl acetate, propionate, and i-butyrate esters were in agreement with literature values. The 4 and 5 carbon esters of 1-methyl-4-piperidinol were specific for butyrylcholinesterase and cleaved in the rank order n-valerate > n-butyrate >> 2-methylbutyrate, iso-valerate. These spectrophotometric results were also in agreement with in vitro hydrolysis rates in mouse blood and with in vivo regional retention of radioactivity in mouse brain of 11C-labeled analogs. Brain uptake and apparent enzymatic rate constants for 1-[11C]methyl-4-piperidinyl n-butyrate and n-valerate were calculated from in vivo measurements in M. nemistrina using positron emission tomography. Based on higher brain uptake of radioactivity and superior pharmacokinetics, 1-[11C]methyl-4-piperidinyl n-butyrate was identified as a new radiopharmaceutical for the in vivo measurement of butyrylcholinesterase activity.
Call-by-Value is Dual to Call-by-Name

The rules of classical logic may be formulated in pairs corresponding to De Morgan duals: rules about & are dual to rules about ∨ . A line of work, including that of Filinski (1989), Griﬃn (1990), Parigot (1992), Danos, Joinet, and Schellinx (1995), Selinger (1998,2001), and Curien and Herbelin (2000), has led to the startling conclusion that call-by-value is the de Morgan dual of call-by-name. This paper presents a dual calculus that corresponds to the classical sequent calculus of Gentzen (1935) in the same way that the lambda calculus of Church (1932,1940) corresponds to the intuitionistic natural deduction of Gentzen (1935). The paper includes crisp formulations of call-by-value and call-by-name that are obviously dual; no similar formulations appear in the literature. The paper gives a CPS translation and its inverse, and shows that the translation is both sound and complete, strengthening a result in Curien and Herbelin (2000).
Erythrocyte Sialic Acid Content during Aging in Humans: Correlation with Markers of Oxidative Stress

Sialic acids are substituted neuraminic acid derivatives which are typically found at the outermost end of glycan chains on the membrane in all cell types. The role of erythrocyte membrane sialic acids during aging has been established however the relationship between sialic acid and oxidative stress is not fully understood. The present work was undertaken to analyze the relationship between erythrocyte membrane sialic acid with its plasma level, membrane and plasma lipid hydroperoxide levels and plasma total antioxidant capacity. Results show that sialic acid content decreases significantly (P < 0.001) in RBC membrane (r = −0.901) and increases in plasma (r = 0.860) as a function of age in humans. Lipid peroxidation measured in the form of hydroperoxides increases significantly (P < 0.001) in plasma (r = 0.830) and RBC membranes (r = 0.875) with age in humans. The Trolox Equivalent Total Antioxidant Capacity (TETAC) of plasma was found to be significantly decreased (P < 0.001, r = −0.844). We observe significant correlations between decrease of erythrocyte membrane sialic acid and plasma lipid hydroperoxide and TETAC. Based on the observed correlations, we hypothesize that increase in oxidative stress during aging may influence the sialic acid decomposition from membrane thereby altering the membrane configuration affecting many enzymatic and transporter activities. Considering the importance of plasma sialic acid as a diagnostic parameter, it is important to establish age-dependent reference.
The Geometry of ROC Space: Understanding Machine Learning Metrics through ROC Isometrics

Many different metrics are used in machine learning and data mining to build and evaluate models. However, there is no general theory of machine learning metrics, that could answer questions such as: When we simultaneously want to optimise two criteria, how can or should they be traded off? Some metrics are inherently independent of class and misclassification cost distributions, while other are not -- can this be made more precise? This paper provides a derivation of ROC space from first principles through 3D ROC space and the skew ratio, and redefines metrics in these dimensions. The paper demonstrates that the graphical depiction of machine learning metrics by means of ROC isometrics gives many useful insights into the characteristics of these metrics, and provides a foundation on which a theory of machine learning metrics can be built.
Distributed verification and hardness of distributed approximation

We study the verification problem in distributed networks, stated as follows. Let H be a subgraph of a network G where each vertex of G knows which edges incident on it are in H. We would like to verify whether H has some properties, e.g., if it is a tree or if it is connected (every node knows in the end of the process whether H has the specified property or not). We would like to perform this verification in a decentralized fashion via a distributed algorithm. The time complexity of verification is measured as the number of rounds of distributed communication. In this paper we initiate a systematic study of distributed verification, and give almost tight lower bounds on the running time of distributed verification algorithms for many fundamental problems such as connectivity, spanning connected subgraph, and s-t cut verification. We then show applications of these results in deriving strong unconditional time lower bounds on the hardness of distributed approximation for many classical optimization problems including minimum spanning tree, shortest paths, and minimum cut. Many of these results are the first non-trivial lower bounds for both exact and approximate distributed computation and they resolve previous open questions. Moreover, our unconditional lower bound of approximating minimum spanning tree (MST) subsumes and improves upon the previous hardness of approximation bound of Elkin [STOC 2004] as well as the lower bound for (exact) MST computation of Peleg and Rubinovich [FOCS 1999]. Our result implies that there can be no distributed approximation algorithm for MST that is significantly faster than the current exact algorithm, for any approximation factor. Our lower bound proofs show an interesting connection between communication complexity and distributed computing which turns out to be useful in establishing the time complexity of exact and approximate distributed computation of many problems.
Low Maternal Viral Loads and Reduced Granulocyte-Macrophage Colony-Stimulating Factor Levels Characterize Exposed, Uninfected Infants Who Develop Protective Human Immunodeficiency Virus Type 1-Specific Responses

ABSTRACT Human immunodeficiency virus type 1 (HIV-1)-specific cellular immune responses are elicited in a proportion of infants born to HIV-1-infected mothers and are associated with protection against vertical transmission. To investigate correlates of these HIV-1-specific responses, we examined levels of the immune activation markers neopterin, β2-microglobulin (β2-m), and soluble l-selectin (sl-selectin); the immunomodulatory and hematopoietic factors interleukin-7 (IL-7), stromal-cell-derived factor 1 alpha (CXCL12), and granulocyte-macrophage colony-stimulating factor (GM-CSF); and the immunoregulatory cytokine IL-10 among a group of newborns born to HIV-1-positive mothers who did not receive any antiretroviral drugs for prevention of perinatal HIV-1 transmission. Cellular immune responses to HIV-1 envelope (Env) peptides were also measured. We aimed to determine whether newborns who elicit HIV-1-specific cellular immune responses (Env+) and those who lack these responses (Env−) exhibit unique immune features. Our data confirmed that no Env+ infants acquired HIV-1 infection. Among exposed, uninfected infants, Env+ infants had reduced immune activation (as measured by β2-m and sl-selectin levels in cord blood plasma) compared to Env− infants as well as reduced GM-CSF levels in cord blood plasma. There was also a reduced ability of cord blood mononuclear cells to be induced to produce GM-CSF among Env+ infants. Maternal viral load was lower in Env+ infants, suggesting that exposure to low levels of antigen may be responsible for priming the protective responses. These findings suggest that infants who are able to develop apparently protective HIV-1-specific cellular immune responses have immunological features and viral exposure histories that distinguish them from their nonresponder counterparts, providing new insights into the development of HIV-1 protective immunity.