Miracle-dz/UniFAR-FTUs huggingface dataset:
Sustained ventricular arrhythmias in patients receiving thrombolytic therapy: incidence and outcomes. The GUSTO Investigators.

BACKGROUND Sustained ventricular tachycardia (VT) and fibrillation (VF) occur in up to 20% of patients with acute myocardial infarction (MI) and have been associated with a poor prognosis. The relationships among the type of arrhythmia (VT versus VF or both), time of VT/VF occurrence, use of thrombolytic agents, and eventual outcome are unclear. METHODS AND RESULTS In the GUSTO-I study, we examined variables associated with the occurrence of VT/VF and its impact on mortality. Of the 40 895 patients with ventricular arrhythmia data, 4188 (10.2%) had sustained VT, VF, or both. Older age, systemic hypertension, previous MI, Killip class, anterior infarct, and depressed ejection fraction were associated with a higher risk of sustained VT and VF (P<0.001). In-hospital and 30-day mortality rates were higher among patients with sustained VT/VF than among patients without sustained ventricular arrhythmias (P<0.001). Both early (<2 days) and late (>2 days) occurrences of sustained VT and VF were associated with a higher risk of later mortality (P<0. 001). In addition, patients with both VT and VF had worse outcomes than those with either VT or VF alone (P<0.001). Among patients who survived hospitalization, no significant difference was found in 30-day mortality between the VT/VF and no VT/VF groups. However, after 1 year, the mortality rate was significantly higher in the VT alone and VT/VF groups (P<0.0001). CONCLUSIONS Despite the use of thrombolytic therapy, both early and late occurrences of sustained VT or VF continue to have a negative impact on patient outcome; patients with both VT and VF had the worst outcome; and among patients who survived hospitalization, the 1-year mortality rate was significantly higher in those who experienced VT alone or VT and VF.
Exploring academics' experiences of a merger in higher education: The reflective experience of mergers (REM)- framework

In contrast to most mergers and acquisition literature which focuses on merger activity in the business world, this paper examines the University of Johannesburg (UJ) merger, which is typical of transformation in South African Higher Education. This merger does not conform to the norm, as it is ideologically motivated and thus the ideal base to study individual experiences of large scale change. Following a qualitative, case study approach, 40 academic employees from UJ were interviewed. Findings indicate that academics relay their experiences and perceptions of the merger in three discernable timeframes, each with its own dynamic. Collectively, these timeframes constitute the reflective experience of mergers (REM) framework, which examines how merger experiences of academic staff shape their perceptions of and attitudes towards the merger over time. The REMframework reiterates the temporal nature of change, its effect on the emotional and psychological wellbeing of individuals, and the role of leadership during a merger.
Marriage, sex, and the first birth interval: the quiet revolution in Asia.

The authors argue that under certain conditions changes in coital frequency do influence fertility. The evidence they present is indirect based on trends in early marital fertility in Korea Malaysia and Taiwan. They offer standard sociodemographic explanations for these trends including later age at marriage improved levels of nutrition and changes in breastfeeding and contraceptive practices and find them wanting for various reasons. The biometric literature is used to show that the effect of coital frequency on the increase in early marital conceptions is plausible; ethnographic illustrations suggest that the movement from the traditionally arranged to the romantically arranged marriage is largely responsible for greater coital frequency. They conclude that a very quiet sexual revolution has been occurring in Asia perhaps more far reaching and profound than the very vocal sexual revolution that has been occurring in the West. The increases in early marital conceptions have been 3 fold or more in some instances. From a broader perspective this paper argues that coital frequency an intermediate variable that has been virtually ignored by demographers can and does have an effect on the pace and level of fertility. The biometric evidence for this effect has been known for some time but heretofore actual behavioral examples have been lacking. The paper further emphasizes the multifaceted nature of the contemporary fertility transitions occurring in the developed world. Differences in coital frequency are very likely a component of differences in levels of natural fertility that have existed and thus not all of the changes taking place lead to lower levels of fertility. The modernizing forces leading to higher rates of coital frequency are in fact leading to higher fertility levels. The aspect of marriage having primary demographic importance is sexual activity--when sexual activity starts when it ends and coital frequency during a sexual union. (summaries in FRE SPA)
Twice daily biphasic insulin aspart improves postprandial glycaemic control more effectively than twice daily NPH insulin, with low risk of hypoglycaemia, in patients with type 2 diabetes

Objective: Biphasic insulin aspart 30 (BIAsp30) is a dual release formulation, containing 30% soluble and 70% protamine‐crystallized insulin aspart. This study compared the glycaemic control and safety profiles achieved with either twice daily BIAsp30 or NPH insulin in patients with type 2 diabetes not optimally controlled by oral hypoglycaemic agents (OHAs), NPH insulin or a combination of both.
Preoperative systemic inflammation and infectious complications after resection of colorectal liver metastases.

BACKGROUND Postoperative complications are associated with a poor long-term prognosis after resection of colorectal liver metastases via an undetermined mechanism. The preoperative systemic inflammatory response, itself a predictor of poor survival, was recently shown to independently predict postoperative infectious complications after primary colorectal cancer resection. OBJECTIVE To examine the association of postoperative infectious complications with preoperative systemic inflammation and survival in patients undergoing resection of colorectal liver metastases. DESIGN Retrospective study based on a prospectively updated database. SETTING A United Kingdom tertiary referral hepatobiliary unit. PATIENTS A total of 202 consecutive patients with colorectal liver metastases undergoing hepatectomy between January 1, 2000, and April 30, 2006. MAIN OUTCOME MEASURES Multivariable analyses were performed to correlate preoperative and operative variables with postoperative complications and to correlate complications with long-term survival after metastasectomy. RESULTS Ninety-day mortality and morbidity were 2.0% and 25.7%, respectively. The preoperative systemic inflammatory response independently predicted the development of infectious complications (P = .009) and major infectious complications (P = .005) after hepatectomy, along with performance of trisectionectomy. Infectious complications were associated with poor long-term survival after metastasectomy but lost independent significance when systemic inflammatory variables were included in multivariable analyses. CONCLUSIONS The preoperative systemic inflammatory response independently predicts the development of infectious complications after colorectal liver metastases resection. Although infectious complications are associated with adverse long-term prognosis after hepatectomy, they lacked independent prognostic value when systemic inflammatory variables were also considered, suggesting that much of their prognostic value arises from their association with the preoperative systemic inflammatory response.
Nucleotide sequence of the 5' noncoding region and part of the gag gene of Rous sarcoma virus

Several functions of the retrovirus genome involve structural features in the vicinity of its 5' terminus. In an effort to further elucidate the relationship between structure and function in retrovirus RNA, we have determined the sequence of the first 1,010 nucleotides at the 5' end of the genome of Rous sarcoma virus by using the Maxam-Gilbert method to sequence suitable domains in cloned Rous sarcoma virus DNA. The results (i) locate the initiation codon for the gag gene of Rous sarcoma virus 372 nucleotides from the 5' end of viral RNA; (ii) demonstrate that this codon is preceded by three methionine codons that are apparently not used in translation; (iii) sustain previous conclusions that the principal site to which ribosomes bind on the Rous sarcoma virus genome in vitro does not contain the initiation codon for gag; (iv) permit deduction of the amino acid sequence of a viral structural protein, p19; (v) confirm the amino-terminal sequence of Pr76gag; and (vi) substantiate the identification of a splice donor site described in the accompanying manuscript (Hackett et al., J. Virol., 41:527-534, 1982).
The role of stakeholders in shaping managerial perceptions of CSR in Russia

This paper investigates the sources of socially responsible behaviour of firms with reference to a survey of managers of medium and large firms in Russia. We argue that agency-oriented analysis is not a good fit for the institutional environment existing in Russia. Consequently, a meaningful management-stakeholder dialogue acquires particular importance. Our results offer some support to the proposition of a link between the interests of the dominant stakeholder and the interpretation of corporate social responsibility entertained by the management of the firm. However, more data are needed to increase the accuracy of results.
Reflections in the Classroom: Perspectives on Teaching for Social Justice from Secondary Social Studies Educators

The purpose of this study was to describe and explain the perspectives of five secondary social studies educators who identified with teaching for social justice. The following research questions guided the study: How do educators who identify with social justice perceive teaching for social justice? ; In what ways do educators who identify with social justice facilitate a social justice education? ; What experiences prompt educators to teach for social justice in the classroom? ; In what ways are educators challenged and rewarded while facilitating a social justice curriculum within the secondary social studies classroom? This qualitative study employed semi-structured interview questions and was conceptually-framed within critical pedagogy. The study provided participants the opportunity to: (1) explore their own perspectives on social justice as both a theory and pedagogy, (2) reflect on the qualities they bring to the classroom regarding social justice, and (3) familiarize others with challenges and rewards as they relate to teaching for social justice. While the study served to further investigate the overarching theme of teaching for social justice, findings revealed: commonalities in how participants define and interpret social justice as both a content and a pedagogy and how they facilitate a social justice approach in the classroom; similarities in the influential power of experiences in the lives of participants and the role these experiences played in both their personal and professional lives; the idea of exposure in that content and people with whom participants were exposed influenced their personal interpretations and understandings; teaching for social justice is not always implemented easily and without challenge, yielding courage and the commitment to stand up for what one believes. While critics argue against this framework and point out its vague and under vi theorized meaning, the study serves to argue that teaching for social justice is inclusive and practical in nature and serves to promote equity and justice. Included within the study are implications based on the findings and the researcher’s interpretations providing recommendations for other researchers, social studies educators that may want to frame future research on similar topics, and recommendations for social studies teacher education programs on implementing and facilitating teaching for social justice.
Risk Factors for Pediatric Invasive Group A Streptococcal Disease

Invasive group A Streptococcus (GAS) infections can be fatal and can occur in healthy children. A case-control study identified factors associated with pediatric disease. Case-patients were identified when Streptococcus pyogenes was isolated from a normally sterile site, and matched controls (≥2) were identified by using sequential-digit dialing. All participants were noninstitutionalized surveillance-area residents <18 years of age. Conditional regression identified factors associated with invasive disease: other children living in the home (odds ratio [OR] = 16.85, p = 0.0002) and new use of nonsteroidal antiinflammatory drugs (OR = 10.64, p = 0.005) were associated with increased risk. More rooms in the home (OR = 0.67, p = 0.03) and household member(s) with runny nose (OR = 0.09, p = 0.002) were associated with decreased risk. Among children, household-level characteristics that influence exposure to GAS most affect development of invasive disease.
The Leader's Role in Managing Change: Five Cases of Technology-Enabled Business Transformation

Transformation is critical for any organization to succeed, and technology-enabled change has become a widespread means of improving responsiveness to competition and customer satisfaction. In the current climate of economic uncertainty, the imperatives that are instrumental in pushing organizations to consider transformation include innovation, business agility to adapt to external changes efficiently and effectively, the alignment of information technology (IT) and business strategy, and global demand and support for new ideas and new opportunities. The critical success factor for such initiatives lies in effective leadership to manage the changes associated with both people and processes. A review of the various aspects of leadership and change management and an analysis of five case studies in technology transformation identify the common leadership parameters that can lead to the effective and efficient adoption of change. ©2015 Wiley Periodicals, Inc.
New Measures of Output, Labour and Capital in Industries of the Russian Economy

Russia is an important part of the world economy both now and in the past. Indeed, one would expect an abundance of studies on Russian economic development. In the past, growth and performance in planned economies vis-a-vis the Western world did attract much attention. These types of studies contributed to two revolutions of development thinking, which are the ? big push? approach based on success of Soviet industrialization in 1930-s and the unexpected collapse of the Soviet Union in 1991. However, recent performance of the Russian economy is less considered while much could be learned from studying the post-Soviet economic development. The key obstacle to the research in case of Russia is data availability. Detailed industrial data of labour, capital and output from early 1990-s onwards is not available both in the official statistics and in the literature. The present paper addresses this gap, providing detailed description of the newly developed dataset, which covers 34 industries in NACE 1.0 classification in 1995-2009. The paper also reports results of output growth rates decomposition into contributions of labour, capital and productivity (industrial growth accounting). Using more detailed data and better theoretical foundation it shows that the contribution of capital to economic growth in Russia is much more substantial that it has previously been reported in the literature until recently.
Understanding The Lived Experiences Of Secondary Teachers Instructing In One-To-One Computing Classrooms

The educational system is changing to meet the needs of 21st century learners, technology integration has become critical in meeting that need. One-to-one computing may close the digital gap that exists and equips students with the skills necessary for success in the 21st century workplace (Lemke & Martin, 2004). While much research exists on the implementation of oneto-one initiatives, further research is needed to explain the teacher’s experiences and perspectives in teaching in such environments in order to investigate effective and successful learning in the classroom. Using a phenomenological methodology, I explored teachers’ lived experiences (Moustakas, 1994) in teaching in a one-to-one computing environment. Analyses of the data revealed six definitve key themes from the teachers’ perspectives of teaching in a one-to-one environment. Those six themes were as follows: 1. Comfort Level with Technological Knowledge. 2. Importance of the Internet. 3. Student Social Skills and Communication. 4. Student Behavior and Classroom Management. 5. Student Accountability and Work Completion. 6. Assessment Practices. Teacher participants revealed that they lacked the knowledge and experience to use technology effectively to enhance the learning process of students. Teachers expressed appreciation for accessibility to information, student accountability, and customization of assessments and grading practices. Classroom management and student communication and social skills were deemed to be impacted negatively by some teacher participants. Further research should look at the implications of differentiated professional development, gender differences among teachers when implementing one-to-one computing, and research in technology integration using the Puentedura’s (2012) SAMR Model would benefit educational institutions as well as educators in setting the goal of attaining the “redefinition” phase of technology integration.
The deterioration of semantic memory in Alzheimer's disease.

Semantic memory impairment is a common feature of dementia of the Alzheimer type (DAT). Recent research has shown that patients with DAT are more impaired (relative to non-demented controls) in generating exemplars from a particular semantic category (e.g., animals) than words beginning with a particular letter, exhibit an altered temporal dynamic during the production of category exemplars, are impaired on confrontation naming tasks and make predominantly superordinate or semantically related errors, consistently misidentify the same objects across a variety of semantic tasks, and have alterations in multi-dimensional scaling models of their semantic network that are indicative of a loss of concepts and associations. These results are consistent with the view that Alzheimer's disease results in a breakdown in the organization and structure of semantic knowledge as neurodegeneration spreads to the association cortices that presumably store semantic representations.
Effect of D-002 on acetic acid-induced colitis in rats at single and repeated doses.

D-002 is a natural mixture of higher aliphatic primary alcohols purified from beeswax, with mild anti-inflammatory and effective antiulcer effects experimentally proved. Furthermore, it reduces leukotriene (LTB(4)) in the exudate of carrageenan-induced pleurisy and has a protective effect on the pre-ulcerative phase of carrageenan-induced colonic ulceration in the guinea pig. This study was conducted to determine the effect of D-002 on acetic acid-induced colitis in rats at single and repeated doses. In a first series, D-002 was orally administered at 25 and 50 mg kg(-1), 24 h before the induction of colitis, meanwhile, in a second series, it was administered 24 h after the induction of colitis. Two other series (III and IV) examined the protective and therapeutic effect of D-002 administered for 7 days at the same doses, before or after colitis induction. Significant reductions in wet weight, macroscopic injury, polymorphonuclear infiltration and wall thickness were observed in colonic mucosa of D-002-treated animals compared with controls in both protective and therapeutic alternatives. It is concluded that D-002 was effective to protect or prevent the damage associated to acetic acid-induced colitis.
Genetic Transformation System for the Fungal Soybean Pathogen Cercospora kikuchii

An altered β-tubulin gene that confers resistance to the fungicide benomyl was isolated from a genomic library of a UV-induced mutant of Cercospora kikuchii and used as a selectable marker for transformation. The level of benomyl resistance conferred to the transformants was at least 150-fold greater than the intrinsic resistance of the C. kikuchii recipient protoplasts. In the majority of cases, the tubulin fragment was integrated at the native β-tubulin locus, apparently by gene replacement or gene conversion. The frequency of transformation ranged from 0.2 to 6 transformants per μg of DNA, depending on the recipient strain. Transformation with linearized plasmid resulted in a higher frequency, without changing the type of integration event. Transformants were phenotypically stable after eight consecutive transfers on medium without benomyl. This is the first report of a genetic transformation system for a Cercospora species.
Optical coherence tomography provides insight into the effect of intacs in keratoconus.

K eratoconus is a bilateral, asymmetric, chronic, initially progressive ectasia of the cornea characterized by steepening, distortion, and thinning of the apical cornea as well as corneal scarring. Intrastromal corneal ring segments (Intacs; Addition Technology Inc, Sunnyvale, California) is 1 treatment option available for patients with keratoconus, especially those with contact lens intolerance. Intacs placement in patients with mild to moderate keratoconus generally improves best spectacle-corrected visual acuity (BSCVA) and uncorrected visual acuity and reduces astigmatism. Intacs have generally been found to be safe and effective. However, the exact effect Intacs have on the keratoconic cornea is still debatable. Here we imaged the corneal changes induced by Intacs using comparative image analysis of optical coherence tomography (OCT).
A comparative study of trends in mortality rates of the ageing population in Norway, Sweden, Denmark, and Finland, 1966-1986

The populations of Finland and the three Scandinavian countries (Denmark, Norway and Sweden) have experienced relatively marked differences regarding trends in mortality rates since the Second World War. To assess factors that might contribute to these differences, a cohort analysis was performed based upon vital statistics for the age category 45 years to 89 years, from the four countries, for the period 1966-86. The results of log-linear modelling, which included the effects of age, period, and cohort, on mortality rates, revealed differences in the effect of age parameters on mortality between Finland and the three Scandinavian countries. These differences may be related to a genetic component. Differences in patterns of mortality rates over time relating to period and cohort effects indicate a differential development in lifestyle-related risk factors associated with the major causes of death. Based on differences in goodness-of-fit of the log-linear models, it is suggested that the Finnish population has experienced a more heterogeneous development in mortality over time than has the Scandinavian. This may be related to the greater social inequities that have existed in Finland than in Scandinavia during the decades under study.