Miracle-dz/UniFAR-FTUs huggingface dataset:
How much did you actually drink last night? An evaluation of standard drink labels as an aid to monitoring personal consumption

Abstract Background: Barriers exist for drinkers who wish to comply with low-risk guidelines when these are expressed in terms of numbers of “standard drinks” of alcohol. The increasing variability of container sizes and alcoholic strengths mean that percent alcohol by volume (%ABV) labels alone may be insufficient. Aims: To investigate whether standard drink (SD) labels would improve drinkers’ accuracy when estimating personal alcohol consumption. Setting: Private liquor stores near the University of Victoria, BC. Design: A 2 × 3 × 3 experimental design was employed with two labels (%ABV and SD), three beverages (beer, wine, and spirits) and three beverage strengths in balanced order. Subjects estimated the number of standard drinks that would be consumed in scenarios involving containers of their preferred beverages presented with different labels. Participants: A convenience sample of 301 liquor store patrons, aged 19 years and over. Measurements: Participants’ accuracy was determined by the relative and absolute percent errors in their estimations in comparison with correct answers. Results: Estimates were significantly more accurate with SD than %ABV labels in almost all the scenarios. Significantly more underestimation errors were made with %ABV labels. Mixed model regression analysis indicated younger respondents, beer drinkers and those with higher education made significantly fewer errors. Most (82.7%) supported SD labelling and believed SD labels would help them to comply with low-risk drinking guidelines (68.3%). Conclusions: The addition of clear SD labels helps consumers to make more accurate estimates of the SD content of their usual beverages than %ABV labels alone and would be more likely to help them comply with drinking guidelines.
Mixed ethnicity, identity and adoption: research, policy and practice

Mixed ethnicity children are over-represented in the care system and constitute a significant group of those seeking adoption placements. Social workers are presented with a specific set of concerns in seeking to find adoption placements for mixed ethnicity children as they come from two or more cultural backgrounds. Practitioners face uncertain principles concerning how to respond to these issues, especially in light of social and political pressures, and within the realm of existing debates around ‘transracial’ adoption. There is a danger that among these uncertainties the individuality of the child will be lost as his or her identity needs become viewed narrowly. Social workers may seek to simplify and classify the identities of mixed ethnicity children in the adoption process through pressures that they feel to find ‘matched’ placements. This paper explores how theories concerning identity can provide some insight into the difficulties practitioners face and may help to inform social work practice in this area.
A Model Program for Churches and Ex-Offender Reintegration.

Abstract In this paper, we examine a community- and church-based demonstration program, Prison Fellowship's Transition of Prisoners (TOP) program in Detroit, that mobilizes, trains, and equips primarily African-American churches and volunteers to assist ex-offenders to successfully reintegrate into their community upon their return from prison. We describe the purpose, social context, and structure of the program. We also explore how the program assesses the needs of its participants with the Level of Service Inventory Revised, and matches its services to those needs. Finally, we show that preliminary outcome data suggests that the participation of ex-offenders in TOP significantly reduces their level of need, their risk of recidivism, and their actual recidivism.
The Discovery of Suicide in Eastern and Southern Africa

Historically African societies have been assumed to have low suicide rates, though there is little conclusive evidence to support this assertion and it is informed by dubious colonial assumptions about the nature of African subjectivity. In particular, longitudinal evidence is lacking. In recent years suicide has begun to attract the attention of psychiatry professionals in Eastern and Southern Africa and of the media. It is now widely argued that suicide rates are increasing, and in some places concern around suicide has taken the appearance of a ‘moral panic’. Suicide is invested with a variety of meanings across the two regions. The results of a small-scale study of attitudes to suicide in Malawi are reported.
Alpha- and beta-adrenergic receptor blockade in the treatment of hypertension.

The effects of single and combined selective blockade of the sympathetic alpha-and beta-receptors were examined in patients with severe hypertension (diastolic pressure > I20 mmHg) uncomplicated by cardiac or renal failure. Given intravenously to 12 patients the alpha-receptor antagonist phentolamine and the beta-receptor antagonist oxprenolol together produced a reduction in systemic arterial pressure to normal levels and a reduction in left ventricular end-diastolic pressure without change in the cardiac output; these effects were maintained. Separately, neither drug resulted in such a satisfactory circulatory reponse. In 6 patients continued oral treatment for 6 months with progressively increased doses of oxprenolol alone up to 480 mg daily, in divided doses, produced a moderate reduction in blood pressure. The addition of oral phentolamine 20 mg t.d. s. resulted in an immediate reduction of blood pressure to normal levels, both at rest and during walking, without postural or other side effects, and without habituation to treatment over a period of 6 months. Arguments are presented that such treatment may have significant advantages over other current medicinal treatments of severe hypertensive vascular disease.
Incremental Mining of Shocking Association Patterns

— Association rules are an important problem in data mining. Massively increasing volume of data in real life databases has motivated researchers to design novel and incremental algorithms for association rules mining. In this paper, we propose an incremental association rules mining algorithm that integrates shocking interestingness criterion during the process of building the model. A new interesting measure called shocking measure is introduced. One of the main features of the proposed approach is to capture the user background knowledge, which is monotonically augmented. The incremental model that reflects the changing data and the user beliefs is attractive in order to make the over all KDD process more effective and efficient. We implemented the proposed approach and experiment it with some public datasets and found the results quite promising.
Facets of Career Satisfaction for Women Physicians in the United States: A Systematic Review

Women make up a growing proportion of the physician workforce, and their career satisfaction may affect their health. The authors hypothesized that many facets adversely affecting career satisfaction in women physicians were extrinsic, therefore, preventable or modifiable. The authors conducted a systematic review of the literature in English published through February 2010 to examine facets of career satisfaction of U.S. women physicians. The authors used the women physician AND job satisfaction OR career satisfaction Medical Subject Headings (MeSH) terms, and reviewed bibliographies of key articles to ensure inclusion of relevant studies. The authors used the “Strengthening the Reporting of Observation Studies in Epidemiology” quality tool. Of an initial 1,000 studies, only 30 met the inclusion criteria. Facets reported most frequently to influence career satisfaction for women physicians were income/prestige, practice characteristics, and personal/family characteristics. Overall, career satisfaction for women and men physicians was 73.4% (range = 56.4% to 90%) and 73.2% (range = 59% to 90%), respectively. When compared with men, women physicians were more concerned with perceived lack of time for relationships with patients, colleagues, and family; less satisfied with mentoring relationships and support from all sources; and less satisfied with career-advancement opportunities, recognition, and salary. Career satisfaction can affect health, as well as health and safety of patients. Many factors adversely affecting career satisfaction for women physicians are extrinsic and, therefore, modifiable.
Frequency-Domain Adaptive Kalman Filter With Fast Recovery of Abrupt Echo-Path Changes

The frequency-domain Kalman filter (FDKF) was successfully applied in echo-cancelation systems due to its fast initial convergence and robustness to double-talk. However, the reconvergence ability of the FDKF was not comprehensively resolved and analyzed in the literature. This letter presents the steady-state solutions of the predicted system distance and corresponding step size of the FDKF, which is found to be related to the signal-to-noise ratio and the transition parameter. On this basis, it is pointed out that a frequently observed slow reconvergence of the FDKF, when the sudden echo-path change occurs, can be mainly attributed to the over-estimated noise power spectral density. Finally, we propose a shadow filter approach to resolve the algorithm's lack of reconvergence. Computer simulations of acoustic echo cancelation confirm the improved performance of the proposed method.
Examining Two Sets of Introgression Lines in Rice (Oryza sativa L.) Reveals Favorable Alleles that Improve Grain Zn and Fe Concentrations

In the modern world, the grain mineral concentration (GMC) in rice (Oryza sativa L.) not only includes important micronutrient elements such as iron (Fe) and zinc (Zn), but it also includes toxic heavy metal elements, especially cadmium (Cd) and lead (Pb). To date, the genetic mechanisms underlying the regulation of GMC, especially the genetic background and G × E effects of GMC, remain largely unknown. In this study, we adopted two sets of backcross introgression lines (BILs) derived from IR75862 (a Zn-dense rice variety) as the donor parent and two elite indica varieties, Ce258 and Zhongguangxiang1, as recurrent parents to detect QTL affecting GMC traits including Fe, Zn, Cd and Pb concentrations in two environments. We detected a total of 22 loci responsible for GMC traits, which are distributed on all 12 rice chromosomes except 5, 9 and 10. Six genetic overlap (GO) regions affecting multiple elements were found, in which most donor alleles had synergistic effects on GMC. Some toxic heavy metal-independent loci (such as qFe1, qFe2 and qZn12) and some regions that have opposite genetic effects on micronutrient (Fe and Zn) and heavy metal element (Pb) concentrations (such as GO-IV) may be useful for marker-assisted biofortification breeding in rice. We discuss three important points affecting biofortification breeding efforts in rice, including correlations between different GMC traits, the genetic background effect and the G × E effect.
Childhood trajectories of inattention and hyperactivity and prediction of educational attainment in early adulthood: a 16-year longitudinal population-based study.

OBJECTIVE Literature clearly documents the association between mental health problems, particularly attention deficit hyperactivity disorder (ADHD), and educational attainment. However, inattention and hyperactivity are generally not considered independently from each other in prospective studies. The aim of the present study was to differentiate the unique, additive, or interactive contributions of inattention and hyperactivity symptoms to educational attainment. METHOD The authors randomly selected 2,000 participants from a representative sample of Canadian children and estimated developmental trajectories of inattention and hyperactivity between the ages of 6 and 12 years using yearly assessments. High school graduation status, at age 22-23 years, was obtained from official records. RESULTS Four trajectories of inattention and four trajectories of hyperactivity were observed between the ages of 6 and 12 years. After controlling for hyperactivity and other confounding variables, a high inattention trajectory (compared with low inattention) strongly predicted not having a high school diploma at 22-23 years of age (odds ratio=7.66, 95% confidence interval [CI]=5.06-11.58). To a lesser extent, a declining or rising trajectory of inattention also made a significant contribution (odds ratios of 2.67 [95% CI=1.90-3.75] and 3.87 [95% CI=2.75-5.45], respectively). Hyperactivity was not a significant predictor once inattention was taken into account. CONCLUSIONS Inattention rather than hyperactivity during elementary school significantly predicts long-term educational attainment. Children with attention problems, regardless of hyperactivity, need preventive intervention early in their development.
Predictors of Smoke-Free Policies in Affordable Multiunit Housing, North Carolina, 2013

Introduction Smoke-free policies can effectively protect nonsmokers from secondhand smoke (SHS) exposure in multiunit housing. We surveyed all affordable multiunit housing properties in North Carolina to determine the statewide prevalence of smoke-free policies and to identify predictors of smoke-free policies. Methods Representatives of affordable housing properties in North Carolina completed a mailed or online survey during June through October 2013. The primary outcome measure was presence of a smoke-free policy, defined as prohibiting smoking in all residential units. We used χ2 analysis and multivariate logistic regression to identify correlates of smoke-free policies. Results Of 1,865 eligible properties, responses were received for 1,063 (57%). A total of 16.5% of properties had policies that prohibited smoking in all residential units, while 69.6% prohibited smoking in indoor common areas. In multivariate analysis, an increase in the number of children per unit was associated with a decrease in the odds of having a smoke-free policy at most properties. Newer properties across all company sizes were more likely to have smoke-free policies. Accessing units from interior hallways predicted smoke-free policies among medium-sized companies. Conclusion More smoke-free policies in affordable multiunit housing are needed to protect vulnerable populations, particularly children, from SHS exposure. Public health professionals should continue to educate housing operators about SHS and the benefits of smoke-free policies at all properties, including older ones and ones where units are accessed from outside rather than from an interior hallway.
Ingesting a Combined Carbohydrate and Essential Amino Acid Supplement Compared to a Non-Nutritive Placebo Blunts Mitochondrial Biogenesis-Related Gene Expression after Aerobic Exercise

Abstract Background: Whether load carriage (LC), an endurance exercise mode composed of the aerobic component of traditional endurance exercise [e.g., cycle ergometry (CE)] and contractile forces characteristic of resistive-type exercise, modulates acute mitochondrial adaptive responses to endurance exercise and supplemental nutrition [carbohydrate + essential amino acids (CHO+EAA)] is not known. Objective: The aim of this study was to examine the effects of LC and CE, with or without CHO+EAA supplementation, on acute markers of mitochondrial biogenesis. Methods: Twenty-five adults performed 90 min of metabolically matched LC (treadmill walking, wearing a vest equal to 30% of body mass) or CE exercise during which CHO+EAA (46 g carbohydrate and 10 g essential amino acids) or non-nutritive control (CON) drinks were consumed. Muscle biopsy samples were collected at rest (pre-exercise), post-exercise, and after 3 h of recovery to assess citrate synthase activity and the expression of mRNA (reverse transcriptase–quantitative polymerase chain reaction) and protein (Western blot). Results: Citrate synthase and phosphorylated p38 mitogen-activated protein kinase (p38 MAPK)Thr180/Tyr182 were elevated postexercise compared with pre-exercise (time main effect, P < 0.05). Peroxisome proliferator-activated γ-receptor coactivator 1α (PGC-1α) expression was highest after recovery for CE compared with LC (exercise-by-time effect, P < 0.05). Sirtuin 1 (SIRT1) expression postexercise was higher for CON than for CHO+EAA treatments (drink-by-time, P < 0.05). Tumor suppressor p53 (p53), mitochondrial transcription factor A (TFAM), and cytochrome c oxidase subunit IV (COXIV) expression was greater for CON than for CHO+EAA treatments (drink main effect, P < 0.05). PGC-1α and p53 expressions were positively associated (P < 0.05) with TFAM (r = 0.629 and 0.736, respectively) and COXIV (r = 0.465 and 0.461, respectively) expressions. Conclusions: Acute mitochondrial adaptive responses to endurance exercise appear to be largely driven by exogenous nutrition availability. Although CE upregulated PGC-1α expression to a greater extent than LC, downstream signaling was the same between modes, suggesting that LC, in large part, elicits the same acute mitochondrial response as traditional, non–weight-bearing endurance exercise. This trial was registered at clinicaltrials.gov as NCT01714479.
HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4

Objective—Endoluminal vascular interventions such as angioplasty initiate a sterile inflammatory response resulting from local tissue damage. This response drives the development of intimal hyperplasia (IH) that, in turn, can lead to arterial occlusion. We hypothesized that the ubiquitous nuclear protein and damage-associated molecular pattern molecule, high-mobility group box 1 (HMGB1), is one of the endogenous mediators that activates processes leading to IH after endoluminal injury to the arterial wall. The aim of this study is to investigate whether approaches that reduce the levels of HMGB1 or inhibit its activity suppresses IH after arterial injury. Approach and Results—Here, we show that HMGB1 regulates IH in a mouse carotid wire injury model. Induced genetic deletion or neutralization of HMGB1 prevents IH, monocyte recruitment, and smooth muscle cell growth factor production after endoluminal carotid artery injury. A specific inhibitor of HMGB1 myeloid differentiation factor 2–toll-like receptor 4 (TLR4) interaction, P5779, also significantly inhibits IH. HMGB1 deletion is mimicked in this model by global deletion of TLR4 and partially replicated by myeloid-specific deletion of TLR4 but not TLR2 or receptor for advanced glycation endproducts deletion. The specific HMGB1 isoform known to activate TLR4 signaling (disulfide HMGB1) stimulates smooth muscle cell to migrate and produce monocyte chemotactic protein 1/CCL2) via TLR4. Macrophages produce smooth muscle cell mitogens in response to disulfide HMGB1 also in a TLR4/myeloid differentiation primary response gene (88)/Trif-dependent manner. Conclusions—These findings place HMGB1 and its receptor, TLR4 as critical regulators of the events that drive the inflammation leading to IH after endoluminal arterial injury and identify this pathway as a possible therapeutic target to limit IH to attenuate damage-associated molecular pattern molecule–mediated vascular inflammatory responses.
Aquilegia as a model system for the evolution and ecology of petals

The ranunculid genus Aquilegia holds extraordinary promise as a model system for investigating a wide range of questions relating to the evolution and ecology of petals. New genetic and genomic resources, including an extensive EST database, BAC libraries and physical maps, as well as virus-induced gene silencing are facilitating this research on multiple fronts. At the developmental genetic level, Aquilegia has been important for elucidating the developmental programme for specifying petals and petaloid characteristics. Data suggest that duplication events among the petal and stamen identity genes have resulted in sub- and neofunctionalization. This expansion of gene function does not include the petaloidy of Aquilegia sepals, however, which does not depend on the same loci that control identity of the second whorl petals. Of special interest is the elaboration of the petal into a nectar spur, a major innovation for the genus. Intra- and interspecific variation in the shape and colour of petals, especially the spurs, has been shown to be adaptative for different pollinators. Thus, understanding the genetic basis of these traits will help us connect the ecological interactions driving speciation with the genetic changes responsible for remodelling morphology. Progress in this area has focused on the multiple, parallel transitions in flower colour and nectar spur length across the genus. For flower colour, upstream transcription factors appear to be primarily targets of natural selection. Thus research in Aquilegia spans the initial evolution of petals and petaloidy to the diversification of petal morphology to the ecological basis of petal form, thereby providing a comprehensive picture of the evolutionary biology of this critical angiosperm feature.
Identification of Canine Coronavirus Strains from Feces by S Gene Nested PCR and Molecular Characterization of a New Australian Isolate

ABSTRACT A nested PCR (nPCR) assay for the detection of canine coronavirus (CCV) in fecal samples is described. The target sequence for the assay was a 514-bp fragment within the spike (S) glycoprotein gene. The sensitivity of the assay is extremely high, detecting as little as 25 50% tissue culture infective doses per g of unprocessed feces. A clinical trial using dogs challenged orally with CCV SA4 and CCV NVSL was used to compare viral isolation and the nPCR assay as detection techniques over a 2-week period of infection. Virus isolation detected CCV shedding from day 4 to 9 postchallenge, while the nPCR assay detected CCV shedding from day 4 to 13 postchallenge. Cloning and sequencing of the nPCR assay product enabled investigation of the evolutionary relationships between strains within the S gene. The simple and rapid procedure described here makes this assay an ideal alternative technique to electron microscopy and viral isolation in cell culture for detection of CCV shedding in feces. The described assay also provides a method of identifying new strains of CCV without the complicated and time-consuming practice of raising antibodies to individual strains. This is illustrated by the identification, for the first time, of an Australian isolate of CCV (UWSMN-1).
The Impact of Probability Judgments on Reasoning about Multiple Possibilities.

HOROBIN, KAREN, and ACREDOLO, CURT. The Impact of Probability Judgments on Reasoning about Multiple Possibilities. CHILD DEVELOPMENT, 1989, 60, 183-200. When confronted with indeterminate problems, young children tend to select only 1 of the possible alternatives. The cause of this inappropriate closure was explored here in 2 studies in which children were administered random mixtures of single-solution and multiple-solution problems. A modified version of Pieraut-Le Bonniec's simple box problem was administered to 7-, 9-, and 12-year-old children, and a version of Acredolo and Horobin's complex relational reasoning task was administered to 9and 12-year-old children. In both studies, children were presented with the problems in both of 2 formats, 1 in which they were to list all possible solutions to each problem from a set of 3 alternatives, and a second in which they were to assign subjective probabilities to each of the 3 alternatives on a 5-point scale. Despite a strong tendency to close on single alternatives, most children correctly assigned nonzero probabilities to each of the possible alternatives. Furthermore, the tendency to acknowledge more than 1 alternative as possible correlated reliably with the tendency to assign equal as opposed to unequal probabilities to the possible alternatives. These results support the hypothesis that 1 major cause of inappropriate closure among young children is the confusion of possibility with probability.