Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanical properties of individual southern pine fibers. Part III. Global relationships between fiber properties and fiber location within an individual tree.

This is the third and final paper in a three-part series investigating the effect of location within a tree on the mechanical properties of individual wood tracheids. This paper focuses on the definition of juvenile, transition, and mature zones as classified by fiber stiffness, strength, microfibril angle, and cross-sectional area. The average modulus of elasticity and ultimate tensile stress of all loblolly pine fibers were, in equal proportion of earlywood and latewood, 17.3 Gpa and 824 Mpa, respectively. The average microfibril angle was found to be 15.4 degrees, with rings 5 and 48 averaging 26.8 and 6.1 degrees, respectively. Normalization of all mechanical and physical properties showed that the juvenile zone is not cylindrical but rather biconical, tapering from stump to below the live crown and then again from the live crown to the bole tip. The transition zone parallels the juvenile zone, ranging in width from 3 to 15 rings. Fiber properties continued to improve slightly throughout the duration of the mature zone.
Reversal mechanisms in perpendicularly magnetized nanostructures

We demonstrate that magnetic reversal in perpendicularly magnetized nanostructures is highly dependent on the nature and condition of the edges. To understand the impact of edge damage, we compare nanostructures created by ion milling to those prepared on prepatterned substrates. The size- and temperature-dependent reversal properties of 25 nm–1 m diameter nanodots show that reversal in prepatterned nanostructures is controlled by nucleation within the interior, whereas ion milling results in an edge nucleation process with an unpredicted temperature dependence of the reversal field.
El ahorro y 1a tasa de interes real en los paises en desarrollo [Saving and the Real Interest Rate in Developing Countries]

Raising real interest rates has been cited as a way to increase private saving, and thus provide the resources for growth. But this may not be a viable approach in the poorest developing countries in which most people live at subsistence level. In these situations, consumption is not very responsive to fluctuations in real interest rates and financial liberalization my not be the catalyst to higher higher saving rates.
Physiological responses to food intake throughout the day

Circadian rhythms act to optimise many aspects of our biology and thereby ensure that physiological processes are occurring at the most appropriate time. The importance of this temporal control is demonstrated by the strong associations between circadian disruption, morbidity and disease pathology. There is now a wealth of evidence linking the circadian timing system to metabolic physiology and nutrition. Relationships between these processes are often reciprocal, such that the circadian system drives temporal changes in metabolic pathways and changes in metabolic/nutritional status alter core molecular components of circadian rhythms. Examples of metabolic rhythms include daily changes in glucose homeostasis, insulin sensitivity and postprandial response. Time of day alters lipid and glucose profiles following individual meals whereas, over a longer time scale, meal timing regulates adiposity and body weight; these changes may occur via the ability of timed feeding to synchronise local circadian rhythms in metabolically active tissues. Much of the work in this research field has utilised animal and cellular model systems. Although these studies are highly informative and persuasive, there is a largely unmet need to translate basic biological data to humans. The results of such translational studies may open up possibilities for using timed dietary manipulations to help restore circadian synchrony and downstream physiology. Given the large number of individuals with disrupted rhythms due to, for example, shift work, jet-lag, sleep disorders and blindness, such dietary manipulations could provide widespread improvements in health and also economic performance.
On Improving Space-Time Super Resolution Using a Small Set of Video Inputs

We address the problem of video super resolution - obtaining a single high-resolution video whose spatial and temporal resolutions are higher than any of the input low-resolution videos. We employ a reconstruction based approach using MRF -MAP formalism, and use approximate optimization using graph cuts to carry out the reconstruction. We show that in our formulation it is possible to selectively apply super resolution constraints to low resolution pixels to contribute towards space or time, depending on whether they appear in the static or moving parts of the scene without any prior segmentation. As a consequence, we can achieve space-time magnification factors beyond what is suggested as possible in [19]. We also provide insights on how to keep the super resolution reconstruction problem well-conditioned.
Existence of families of Galois representations and new cases of the Fontaine-Mazur conjecture

Abstract In a previous article, we have proved a result asserting the existence of a compatible family of Galois representations containing a given crystalline irreducible odd two-dimensional representation. We apply this result to establish new cases of the Fontaine-Mazur conjecture, namely, an irreducible Barsotti-Tate λ-adic 2-dimensional Galois representation unramified at 3 and such that the traces ap of the images of Frobenii verify ℚ({a2 p}) = ℚ always comes from an abelian variety. We also show the non-existence of irreducible Barsotti-Tate 2-dimensional Galois representations of conductor 1 and apply this to the irreducibility of Galois representations on level 1 genus 2 Siegel cusp forms.
Migration of Apicomplexa Across Biological Barriers: The Toxoplasma and Plasmodium Rides

The invasive stages of Apicomplexa parasites, called zoites, have been largely studied in in vitro systems, with a special emphasis on their unique gliding and host cell invasive capacities. In contrast, the means by which these parasites reach their destination in their hosts are still poorly understood. We summarize here our current understanding of the cellular basis of in vivo parasitism by two well‐studied Apicomplexa zoites, the Toxoplasma tachyzoite and the Plasmodium sporozoite. Despite being close relatives, these two zoites use different strategies to reach their goal and establish infection.
CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure

MOTIVATION Clustering of individuals into populations on the basis of multilocus genotypes is informative in a variety of settings. In population-genetic clustering algorithms, such as BAPS, STRUCTURE and TESS, individual multilocus genotypes are partitioned over a set of clusters, often using unsupervised approaches that involve stochastic simulation. As a result, replicate cluster analyses of the same data may produce several distinct solutions for estimated cluster membership coefficients, even though the same initial conditions were used. Major differences among clustering solutions have two main sources: (1) 'label switching' of clusters across replicates, caused by the arbitrary way in which clusters in an unsupervised analysis are labeled, and (2) 'genuine multimodality,' truly distinct solutions across replicates. RESULTS To facilitate the interpretation of population-genetic clustering results, we describe three algorithms for aligning multiple replicate analyses of the same data set. We have implemented these algorithms in the computer program CLUMPP (CLUster Matching and Permutation Program). We illustrate the use of CLUMPP by aligning the cluster membership coefficients from 100 replicate cluster analyses of 600 chickens from 20 different breeds. AVAILABILITY CLUMPP is freely available at http://rosenberglab.bioinformatics. med.umich. edu/clumpp.html.
Temporal Dynamics of Cognitive–Emotional Interplay in Moral Decision-making

This study investigated the temporal dynamics of emotional and cognitive processing underlying decision-making in moral judgment. Thirty-seven participants were presented with a set of 60 dilemmas varying in whether killing one individual was an intended means to save others (instrumental dilemmas) or a foreseen but unintended consequence (incidental dilemmas). Participants were required to decide between Options A (letting a specific number of people die) and B (killing one person to save a specific number of people). ERPs were recorded to a slide displaying the letters A and B while subjects were deciding between the options, and movement-related potentials were recorded time-locked to the behavioral response, thus allowing the investigation of both stimulus- and response-related processes during decision-making. Ratings of emotional valence and arousal experienced during decision-making were collected after each decision. Compared with incidental dilemmas, instrumental dilemmas prompted a lower number of B choices and significantly more unpleasant decisions. A larger P260 component was found in the frontopolar and frontal areas when subjects were deciding on instrumental than incidental dilemmas, possibly reflecting an immediate affective reaction during the early stage of assessment and formation of preferences between available options. On the other hand, decisions on incidental dilemmas required greater attentional resources during the fairly controlled later processing, as reflected in the larger slow wave amplitudes. In addition, facilitation of action selection and implementation was found for incidental dilemmas during the second stage of decision-making, as supported by the larger amplitudes of both components of the Bereitschaftspotential.
Co-diversification of Enterococcus faecium Core Genomes and PBP5: Evidences of pbp5 Horizontal Transfer

Ampicillin resistance has greatly contributed to the recent dramatic increase of a cluster of human adapted Enterococcus faecium lineages (ST17, ST18, and ST78) in hospital-based infections. Changes in the chromosomal pbp5 gene have been associated with different levels of ampicillin susceptibility, leading to protein variants (designated as PBP5 C-types to keep the nomenclature used in previous works) with diverse degrees of reduction in penicillin affinity. Our goal was to use a comparative genomics approach to evaluate the relationship between the diversity of PBP5 among E. faecium isolates of different phylogenomic groups as well as to assess the pbp5 transferability among isolates of disparate clonal lineages. The analyses of 78 selected E. faecium strains as well as published E. faecium genomes, suggested that the diversity of pbp5 mirrors the phylogenomic diversification of E. faecium. The presence of identical PBP5 C-types as well as similar pbp5 genetic environments in different E. faecium lineages and clones from quite different geographical and environmental origin was also documented and would indicate their horizontal gene transfer among E. faecium populations. This was supported by experimental assays showing transfer of large (≈180–280 kb) chromosomal genetic platforms containing pbp5 alleles, ponA (transglycosilase) and other metabolic and adaptive features, from E. faecium donor isolates to suitable E. faecium recipient strains. Mutation profile analysis of PBP5 from available genomes and strains from this study suggests that the spread of PBP5 C-types might have occurred even in the absence of a significant ampicillin resistance phenotype. In summary, genetic platforms containing pbp5 sequences were stably maintained in particular E. faecium lineages, but were also able to be transferred among E. faecium clones of different origins, emphasizing the growing risk of further spread of ampicillin resistance in this nosocomial pathogen.
Stress-Related Growth 1 Stress-Related Growth : Correlates and Change Following a Resilience Intervention

Correlates of stress-related growth and effectiveness of a resilience intervention to enhance growth were examined. College students were randomly assigned to an intervention or a wait-list control group. Resources, stressor characteristics, adjustment, and growth were assessed. Results support self-esteem and adaptive coping as growth correlates; introduce a new correlate, selfleadership; suggest depressive symptoms decrease resources while simultaneously promoting growth; and highlight the intervention as a promising growth facilitation approach.
Clinical and Experimental Gastroenterology Dovepress

radiological evaluation of the patency of duodenal-esophageal anastomosis during a long postoperative follow-up: effectiveness of an alkaline reflux model in rats Background: Performing experimental studies has played an important role in acquiring knowledge about esophageal carcinogenesis. In this context, the choice of a more reliable experimental model requires proof of its effectiveness in order to lend greater credibility to the results. The objective of this study was to evaluate the patency of duodenal-esophageal anastomosis during long-term postoperative follow-up in rats. Methods: This was an experimental study in which 45 female Wistar rats were used. A side-to-side anastomosis was performed, going from the anterior side of the esophagus to the second duodenal portion. A standardized radiological technique was used to carry out a contrasted radiological study of the esophagus, stomach, and duodenum during weeks 4, 12, 20, and 30 after surgery. Different contrast media were used, and the animals were divided into groups, ie, group 1 (100% barium sulfate), group 2 (50% barium sulfate), and group 3 (60% aqueous iodinated contrast media). Contrast radiographs were taken in each group at weeks 4, 12, 20, and 30 after the surgical procedure. The radiographic images were evaluated by two radiologists who were blinded regarding the contrast groups. Macroscopic evaluation of each animal was compared with the radiological findings. Results: Postoperative mortality was 13.33%. The remaining animals were divided into study groups. All the contrast radiological examinations showed evidence of the location of the esophagus, stomach, and proximal portion of the intestine, and demonstrated the laterolateral relationship of the distal esophagus and the duodenum in the epigastric region. Patency of the anastomosis was observed at each examination period. The different contrast media used were able to demonstrate this outcome shortly after the first phase of injection. Necropsies corroborated the radiological findings. Conclusion: Regardless of the contrast agent used, contrasted radiography revealed that side-to-side duodenal-esophageal anastomosis in rats allowed patent communication during long-term postoperative follow-up.
Small and Partial Views derived from Limited Experiences

This paper develops a theory of inductive derivations of personal views from experiences focusing on limited trials and partial memories. The theory allows us to discuss how a player might simplify his view of a complicated situation. Two new concepts of marked information pieces and tested actions are introduced for this purpose. Each player accumulates local memories as long-term term memories up to marked pieces and tested actions, and constructs a view. At unmarked pieces, he behaves following his prescribed regular behavior pattern without thinking about it. A derived view is typically small, partial, and sometimes prejudiced relative to the original game situation. This paper studies the emergence of such views. One result is the characterization of a Nash equilibrium relative to the relevant domain of the objective game based on the limited and partial views of the individual players.
On Termination of Integer Linear Loops

A fundamental problem in program verification concerns the termination of simple linear loops of the form:[EQUATION]where x is a vector of variables, u, a, and c are integer vectors, and A and B are integer matrices. Assuming the matrix A is diagonalisable, we give a decision procedure for the problem of whether, for all initial integer vectors u, such a loop terminates. The correctness of our algorithm relies on sophisticated tools from algebraic and analytic number theory, Diophantine geometry, and real algebraic geometry.To the best of our knowledge, this is the first substantial advance on a 10-year-old open problem of Tiwari [38] and Braverman [8].
Using exemplars for the National Certificate of Educational Achievement (NCEA) external assessments : perceptions of secondary school teachers

iii ACKNOWLEDGEMENTS . iv TABLE OF CONTENTS . v LIST OF FIGURES . vii LIST OF ABBREVIATIONS . viii CHAPTER ONE: INTRODUCTION Introduction . 1 Rationale . 1 Research Aims . 3 Research Questions . 3 Thesis Organisation . 3 CHAPTER TWO: LITERATURE REVIEW Introduction.5 Standards Based Assessment and NCEA.5 Value and Use of Exemplars.11 Challenges with Using Exemplars . 14 CHAPTER THREE: METHODOLOGY AND METHODS Introduction . 18 Epistemology.18 Methodology.19 Participant Selection . 20 Research Method: Questionnaire.22
Gene Therapy for Bone Engineering

Bone has an intrinsic healing capacity that may be exceeded when the fracture gap is too big or unstable. In that moment, osteogenic measures need to be taken by physicians. It is important to combine cells, scaffolds and growth factors, and the correct mechanical conditions. Growth factors are clinically administered as recombinant proteins. They are, however, expensive and needed in high supraphysiological doses. Moreover, their half-life is short when administered to the fracture. Therefore, gene therapy may be an alternative. Cells can constantly produce the protein of interest in the correct folding, with the physiological glycosylation and in the needed amounts. Genes can be delivered in vivo or ex vivo by viral or non-viral methods. Adenovirus is mostly used. For the non-viral methods, hydrogels and recently sonoporation seem to be promising means. This review will give an overview of recent advancements in gene therapy approaches for bone regeneration strategies.
A Trio of New Local Group Galaxies with Extreme Properties

We report on the discovery of three new dwarf galaxies in the Local Group. These galaxies are found in new CFHT/MegaPrime g,i imaging of the southwestern quadrant of M31, extending our extant survey area to include the majority of the southern hemisphere of M31’s halo out to 150 kpc. All these galaxies have stellar populations which appear typical of dwarf spheroidal (dSph) systems. The first of these galaxies, Andromeda XVIII, is the most distant Local Group dwarf discovered in recent years, at ~1.4 Mpc from the Milky Way (~600 kpc from M31). The second galaxy, Andromeda XIX, a satellite of M31, is the most extended dwarf galaxy known in the Local Group, with a half-light radius of rh ∼ 1.7 kpc. This is approximately an order of magnitude larger than the typical half-light radius of many Milky Way dSphs, and reinforces the difference in scale sizes seen between the Milky Way and M31 dSphs (such that the M31 dwarfs are generally more extended than their Milky Way counterparts). The third galaxy, Andromeda XX, is one of the faintest galaxies so far discovered in the vicinity of M31, with an absolute magnitude of order MV ∼ − 6.3. Andromeda XVIII, XIX, and XX highlight different aspects of, and raise important questions regarding, the formation and evolution of galaxies at the extreme faint end of the luminosity function. These findings indicate that we have not yet sampled the full parameter space occupied by dwarf galaxies, although this is an essential prerequisite for successfully and consistently linking these systems to the predicted cosmological dark matter substructure.
Localization of 5-HT1A receptors in the living human brain using [carbonyl-11C]WAY-100635: PET with anatomic standardization technique.

UNLABELLED Serotonergic 5-hydroxytryptamine-1A (5-HT1A) receptors are of interest in the pathophysiology of several neuropsychiatric disorders such as anxiety, depression and schizophrenia. [Carbonyl-11C]WAY-100635 has recently been shown to be suitable for quantitative determination of 5-HT1A receptors in the human brain using PET. For group comparisons of neuroreceptor distribution on a pixel-by-pixel basis, an anatomic standardization technique is required. In the current study, we have built a database of normal 5-HT1A receptor distribution using [carbonyl-11C]WAY-100635 and an anatomic standardization technique. METHOD A PET examination lasting 63 min was performed on six subjects after intravenous injection of [carbonyl-11C]WAY-100635. The radioactivity of the PET images were integrated in the interval 12-63 min and normalized by the radioactivity of the cerebellum, providing a measure of the binding potential (BP) in each pixel. Each PET image was transformed into a standard brain anatomy using a computerized brain atlas system. From the standardized PET images, the sample mean and the SD of the BP were calculated in each pixel. RESULT On the anatomically standardized average image, high BP was observed in the cerebral cortices, hippocampus and raphe nucleus, whereas low BP was observed in the basal ganglia and thalamus. This regional distribution is in good agreement with the distribution of 5-HT1A receptors known from in vitro studies. CONCLUSION The anatomic standardization technique permits building of a database of the normal 5-HT1A receptor distribution in the living human brain. This technique can be applied for group comparisons of neuroreceptor distribution on a pixel-by-pixel basis.
Phylogeographic study of Chinese seabuckthorn (Hippophae rhamnoides subsp. sinensis Rousi) reveals two distinct haplotype groups and multiple microrefugia on the Qinghai-Tibet Plateau

Historical climate change can shape the genetic pattern of a species. Studies on this phenomenon provide great advantage in predicting the response of species to current and future global climate change. Chinese seabuckthorn (Hippophae rhamnoides subsp. sinensis) is one of the most important cultivated plants in Northwest China. However, the subspecies history and the potential genetic resources within the subspecies range remain unclear. In this study, we utilized two intergenic chloroplast regions to characterize the spatial genetic distribution of the species. We found 19 haplotypes in total, 12 of which were unique to the Chinese seabuckthorn. The populations observed on the Qinghai-Tibet Plateau (QTP) consisted of most of the haplotypes, while in the northeast of the range of the subspecies, an area not on the QTP, only four haplotypes were detected. Our study also revealed two distinct haplotype groups of the subspecies with a sharp transition region located in the south of the Zoige Basin. 89.96% of the genetic variation located between the regions. Mismatch analysis indicated old expansions of these two haplotype groups, approximately around the early stage of Pleistocene. Additional morphological proofs from existing studies and habitat differentiation supported a long independent colonization history among the two regions. Potential adaptation probably occurred but needs more genome and morphology data in future. Chinese seabuckthorn have an older population expansion compared with subspecies in Europe. The lack of large land ice sheets and the heterogeneous landscape of the QTP could have provided extensive microrefugia for Chinese seabuckthorn during the glaciation period. Multiple localities sustaining high-frequency private haplotypes support this hypothesis. Our study gives clear insight into the distribution of genetic resources and the evolutionary history of Chinese seabuckthorn.