Miracle-dz/UniFAR-FTUs huggingface dataset:
Allogeneic stem cell transplant may improve the outcome of adult patients with inv(16) acute myeloid leukemia in first complete remission with poor molecular responses to chemotherapy

Eighty-six adult patients with inv(16) acute myeloid leukemia (AML) in first complete remission (CR1) were serially monitored for CBFB–MYH11 transcript levels during the early courses of chemotherapy. Fifty-seven and 29 of them received chemotherapy/autologous stem cell transplant (SCT) and allogeneic (allo-)SCT after second consolidation, respectively. For patients receiving chemotherapy/autologous SCT, the sole independent adverse prognostic factor for the cumulative incidence of relapse (CIR), disease-free survival (DFS) and overall survival (OS) was a CBFB–MYH11 level > 0.2% after course 2 consolidation (p = 0.003, 0.003 and 0.031), which was used to define a poor molecular response (MR). Allo-SCT significantly decreased the 3-year CIR and increased the DFS and OS of patients with a poor MR (p < 0.0001, 0.0001 and 0.045) but did not improve the outcome of patients with good MR (all p > 0.05) compared with chemotherapy/autologous SCT. Therefore, allo-SCT could improve the outcome of adult patients with inv(16) AML in CR1 with a poor MR during the early courses of chemotherapy.
Sense of Coherence, Depressive Symptoms, Cardiovascular Diseases, and All-Cause Mortality

Objective There is increasing interest in whether positive and negative psychological constructs are bipolar opposites of the same phenomenon. We examine whether a positive construct—sense of coherence (SOC)—has independent predictive power over and above depressive symptoms for cardiovascular disease (CVD) and all-cause mortality. Methods Participants included 3850 men and 4083 women aged 25 to 74 years who had participated in risk factor surveys conducted in 1992 or 1997. Antonovsky’s 13-item SOC scale was used to measure SOC, and had a correlation of −0.60 with the Beck Depression Inventory. Results During a mean follow-up time of 14.2 years, there were 670 deaths and 487 nonfatal and fatal CVD events. Higher SOC scores were associated with a lower risk of all-cause mortality (relative risk [RR] = 0.90, 95% confidence interval [CI] = 0.84–0.97 per unit), especially among men, but this association became nonsignificant after adjustment for depressive symptoms (RR = 0.99, 95% CI = 0.90–1.08). Among participants without a history of CVD, higher SOC scores were related to a lower risk for CVD (RR = 0.90, 95% CI = 0.83–0.98), but this association disappeared after adjustment for cardiovascular risk factors. Depressive symptoms remained significant predictors of CVD among women in a model including also SOC (RR = 1.24, 95% CI = 1.06–1.46). Conclusions SOC was related to all-cause mortality among men; the association with CVD events was modest. Measures for SOC and depressive symptoms were significantly correlated, which might result in overlap in their associations with adverse disease and mortality outcomes.
Automatic thread extraction with decoupled software pipelining

Until recently, a steadily rising clock rate and other uniprocessor micro architectural improvements could be relied upon to consistently deliver increasing performance for a wide range of applications. Current difficulties in maintaining this trend have lead microprocessor manufacturers to add value by incorporating multiple processors on a chip. Unfortunately, since decades of compiler research have not succeeded in delivering automatic threading for prevalent code properties, this approach demonstrates no improvement for a large class of existing codes. To find useful work for chip multiprocessors, we propose an automatic approach to thread extraction, called decoupled software pipelining (DSWP). DSWP exploits the finegrained pipeline parallelism lurking in most applications to extract long-running, concurrently executing threads. Use of the nonspeculative and truly decoupled threads produced by DSWP can increase execution efficiency and provide significant latency tolerance, mitigating design complexity by reducing intercore communication and per-core resource requirements. Using our initial fully automatic compiler implementation and a validated processor model, we prove the concept by demonstrating significant gains for dual-core chip multiprocessor models running a variety of codes. We then explore simple opportunities missed by our initial compiler implementation which suggest a promising future for this approach.
Loading Rate Effect on Flexural and Indentation Behaviour of Foam Core Composite Sandwich Panel

The present study focuses on the flexural and the indentation behaviour of foam core sandwich panel subject to three point bending and indentation loading at different loading rates. The load-deflection, stress-deflection responses and energy absorption properties of foam core sandwich panel are determined experimentally. The foam core sandwich panel was fabricated using vacuum infusion process. The sandwich structure consists of chopped strand mat fibreglass skins and polyurethane foam core. The flexural and the indentation tests were conducted using Instron Universal Testing machine. It was found that loading rate influences the flexural and the indentation behaviours of foam core sandwich panel. By increasing the loading rate, the stiffness, strength and energy absorption of flexural and indentation of these structures were increased.
Influence of Operation Conditions and Ambient Temperature on Performance of Gas Turbine Power Plant

This paper presents the effect of ambient temperature and operation conditions (compression ratio, turbine inlet temperature, air to fuel ratio and efficiency of compressor and turbine) on the performance of gas turbine power plant. The computational model was developed utilizing the MATLAB codes. Turbine work found to be decreases as ambient temperature increases as well as the thermal efficiency decreases. It can be seen that the thermal efficiency increases linearly with increases of compression ratio while decreases of ambient temperature. The specific fuel consumption increases with increases of ambient temperature and lower turbine inlet temperature. The effect of variation of SFC is more significance at higher ambient temperature than lower temperature. It is observed that the thermal efficiency linearly increases at lower compressor ratio as well as higher turbine inlet temperature until certain value of compression ratio. The variation of thermal efficiency is more significance at higher compression ratio and lower turbine inlet temperature. Even though at lower turbine inlet temperature is decrement the thermal efficiency dramatically and the SFC decreases linearly with increases of compression ratio and turbine inlet temperature at lower range until certain value then increases dramatically for lower turbine inlet temperature.
Harmonic polynomials for expanding the fluctuations of the Cosmic Microwave Background: The Poincare and the 3-sphere model

Fluctuations of the Cosmic Microwave Background CMB are observed by the WMAP. When expanded into the harmonic eigenmodes of the space part of a cosmological model, they provide insight into the large-scale topology of space. All harmonic polynomials on the multiply connected dodecahedral Poincare space are constructed. Strong and specific selection rules are given by comparing the polynomials to those on the 3-sphere, its simply connected cover.
VisualizingBiologicalData inMuseums:VisitorLearningWith an Interactive TreeofLifeExhibit

In this study, we investigate museum visitor learning and engagement at an interactive visualization of an evolutionary tree of life consisting of over 70,000 species. The study was conducted at two natural history museums where visitors collaboratively explored the tree of life using direct touch gestures on a multi-touch tabletop display. In the study, 247 youth, aged 8–15 years, were randomly assigned in pairs to one of four conditions. In two of the conditions, pairs of youth interacted with different versions of the tree of life tabletop exhibit for a fixed duration of 10minutes. In a third condition, pairs watched a 10minute video on a similar topic. Individual responses on a 53-item exit interview were then compared to responses from a fourth, baseline condition. Contrasting with the baseline condition, visitors who interacted with the tabletop exhibits were significantly more likely to reason correctly about core evolutionary concepts, particularly common descent and shared ancestry. They were also more likely to correctly interpret phylogenetic tree diagrams. To investigate the factors influencing these learning outcomes, we used linear mixed models to analyze measures of dyads’ verbal engagement and physical interaction with the exhibit. These models indicated that, while our verbal and physical measures were related, they accounted for significant portions of the variance on their own, independent of youth age, prior knowledge, and parental background. Our results provide evidence that multi-touch interactive exhibits that enable visitors to explore large scientific datasets can provide engaging and effective learning opportunities. # 2016 Wiley Periodicals, Inc. J Res Sci Teach
Relationships between Hygral Expansion, Relaxation Shrinkage, and Extensibility in Woven Wool Fabrics

If a wool fabric is restrained during drying, as in tentering, there is a close relationship between the relaxation shrinkage that is induced and the hygral expansion. A high correlation also exists between the hygral expansion and extensibility of relaxed fabrics. For conventional woven fabrics, this relationship is independent of fabric structure and the finishing routine used. Separate relationships for warp and weft directions exist between extensibility (of relaxed fabric) and relaxation shrinkage in commercial fabrics. The difference in extensibility (at 500 gf/cm) for a relaxed fabric, and the corresponding unrelaxed fabric, is related to the relaxation shrinkage in the unrelaxed fabric.
Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA-cryogel phantom with optimal acoustic and mechanical properties

The accuracy of a transient elastography liver-scanning ultrasound system was assessed using a novel application of PVA-cryogel as a tissue-mimicking material with acoustic and shear elasticity properties optimized to best represent those of liver tissue. Although the liver-scanning system has been shown to offer a safer alternative for diagnosing liver cirrhosis through stiffness measurement, as compared to the liver needle biopsy exam, the scanner's accuracy has not been fully established. Young's elastic modulus values of 5–6 wt% PVA-cryogel phantoms, also containing glycerol and 0.3 µm Al2O3 and 3 µm Al2O3, were measured using a ‘gold standard’ mechanical testing technique and transient elastography. The mechanically measured values and acoustic velocities of the phantoms ranged between 1.6 and 16.1 kPa and 1540 and 1570 m s−1, respectively, mimicking those observed in liver tissue. The values reported by the transient elastography system overestimated Young's elastic modulus values representative of the progressive stages of liver fibrosis by up to 32%. These results were attributed to the relative rather than absolute nature of the measurement arising from the single-point acoustic velocity calibration of the system, rendering the measurements critically dependent on the speed of sound of the sample under investigation. Given the wide range of acoustic velocities which exist in the liver, spanning healthy tissue to cirrhotic pathology, coupled with the system's assumption that the liver is approximately elastic when it is rather highly viscoelastic, care should be exercised when interpreting the results from this system in patient groups.
The gamer experience: Investigating relationships between culture and usability in massively multiplayer online games

Massively multiplayer online games (MMOGs) are persisted virtual worlds capable of supporting hundreds or thousands of gamers simultaneously. Although every MMOG environment has its own “culture,” gamers originate from different countries, speak different languages, and have different national cultural backgrounds. It is assumed that gamers' cultural diversity affects their online gaming experience and their perceptions of a game's usability; nevertheless knowledge is limited and relevant research is rare. This study aims for an empirical investigation between gamers' cultural dimensions and their perceptions of usability. A subjective measurement of usability is given in this study; usability is viewed in more holistic terms, beyond its functional dimensions, so as to capture social and affective dimensions as well, which are very important within the MMOG context. The findings of this exploratory study indicate that there are quantitative relationships between culture and the perception of usability of MMOGs. Such results have practical implications for the designers of MMOGs. A relevant discussion is also presented, along with future research dimensions.
Imaging-Based Features of Headaches in Chiari Malformation Type I.

BACKGROUND Suboccipital cough-induced headaches are considered a hallmark symptom of Chiari malformation type I (CMI). However, non--Valsalva-related suboccipital headaches and headaches in other locations are also common in CMI. The diagnostic significance and the underlying factors associated with these different headaches types are not well understood. OBJECTIVE To compare cranial morphology and hydrodynamics in 3 types of headaches in CMI to better understand the pathophysiological basis for the different headache characteristics. METHODS Twenty-two cranial physiological and morphological measures were obtained with specialized magnetic resonance imaging scans from 63 symptomatic pretreated CMI patients, 40 with suboccipital headaches induced by Valsalva maneuvers (34 women; age, 36 ± 10 years), 15 with non--Valsalva-related suboccipital headaches (10 women; age, 33 ± 9 years), 8 with nonsuboccipital non--Valsalva-induced headaches (8 women; age, 39 ± 13 years), and 37 control subjects (24 women; age, 36 ± 12 years). Group differences were identified with the use of the 2-tailed Student t test. RESULTS Posterior cranial fossa markers of CMI were similar among the 3 headache subtypes. However, the Valsalva-related suboccipital headaches cohort demonstrated a significantly lower intracranial compliance index than the non--Valsalva-related suboccipital headaches cohort (7.5 ± 3.4 vs 10.9 ± 4.9), lower intracranial volume change during the cardiac cycle (0.48 ± 0.19 vs 0.61 ± 0.16 mL), and higher magnetic resonance imaging--derived intracranial pressure (11.1 ± 4.3 vs 7.7 ± 2.8 mm Hg; P = .02). The Valsalva-related suboccipital headaches cohort had smaller intracranial and lateral ventricular volumes compared with the healthy cohort. The non--Valsalva-related suboccipital headaches cohort had reduced venous drainage through the jugular veins. CONCLUSION Valsalva-induced worsening of occipital headaches appears to be related to a small intracranial volume rather than the smaller posterior cranial fossa. This explains the reduced intracranial compliance and corresponding higher pressure measured in CMI patients with headaches affected by Valsalva maneuvers.
GNA13 as a prognostic factor and mediator of gastric cancer progression

Guanine nucleotide binding protein (G protein), alpha 13 (GNA13) has been implicated as an oncogenic protein in several human cancers. In this study, GNA13 was characterized for its role in gastric cancer (GC) progression and underlying molecular mechanisms. The expression dynamics of GNA13 were examined by immunohistochemistry (IHC) in two independent cohorts of GC samples. A series of in-vivo and in-vitro assays was performed to elucidate the function of GNA13 in GC and its underlying mechanisms. In both two cohorts of GC samples, we observed that GNA13 was markedly overexpressed in GC tissues and associated closely with aggressive magnitude of GC progression and poor patients' survival. Further study showed that upregulation of GNA13 expression increased the proliferation and tumorigenicity of GC cells in vitro and in vivo, by promoting cell growth rate, colony formation, and tumor formation in nude mice. By contrast, knockdown of GNA13 effectively suppressed the proliferation and tumorigenicity of GC cells in vitro and in vivo. Our results also demonstrated that the molecular mechanisms of the effect of GNA13 in GC included promotion of G1/S cell cycle transition through upregulation of c-Myc, activation of AKT and ERK activity, suppression of FOXO1 activity, upregulation of cyclin-dependent kinase (CDK) regulator cyclin D1 and downregulation of CDK inhibitor p21Cip1 and p27Kip1. Our present study illustrated that GNA13 has an important role in promoting proliferation and tumorigenicity of GC, and may represent a novel prognostic biomarker and therapeutic target for this disease.
Convergence of the linearized Bregman iteration for ℓ1-norm minimization

One of the key steps in compressed sensing is to solve the basis pursuit problem min u∈ℝ n{∥u∥: Au = f }. Bregman iteration was very successfully used to solve this problem in [40]. Also, a simple and fast iterative algorithm based on linearized Bregman iteration was proposed in [40], which is described in detail with numerical simulations in [35]. A convergence analysis of the smoothed version of this algorithm was given in [11]. The purpose of this paper is to prove that the linearized Bregman iteration proposed in [40] for the basis pursuit problem indeed converges.
Wiretap Channel With Side Information

The wiretap channel put forward by Wyner for many years. In this paper, we consider the situation that the wiretapper can not only view the channel output via a second noisy channel, but also can get some side information about the codeword that transmitted in the main noisy channel. The designer tries to build the encoder-decoder in such a way as to maximize the transmission rate R, and the equivocation d of the information as seen by the wiretapper.We find the capacity region for (R,d) pairs, and in particular, if d is equal to Hs, the entropy of the data source, then we consider that the transmission is accomplished in perfect secrecy.Our result implies that there exists a C ′ s > 0, such that reliable transmission at rates up to C ′ s is possible in perfect secrecy. Index Terms — Wiretap channel, capacity region, perfect secrecy
The Utility of Item-Level Analyses in Model Evaluation: A Reply to Seidenberg and Plaut

Seidenberg and Plaut (this issue) argue that the implications of our analyses (Spieler & Balota, 1997) for the two extant connectionist models of word naming are limited by two factors. First, variables outside the scope of these models influence naming performance, so it is not surprising that the models do not account for much of the variance at the item level. Second, there is error variance associated with large item-level data sets that obviously should not be captured by these models. We point out that there are a number of variables that have been incorporated within the targeted connectionist models that should provide these models an advantage over the simple predictor variables that we selected as a baseline to evaluate the efficacy of the models (e.g., log frequency, length in letters, and number of orthographic neighbors). We also point out that there is considerable consistency across four large-scale studies of item means. Finally, we provide evidence that even under conditions of a standard word-naming study (with a small set of items), simple word frequency, orthographic neighborhoods, and length accounted for more variance than the extant connectionist models. We conclude that item-level analyses provide an important source of evidence in the evaluation of current models and the development of future models of visual word recognition.
Acoustic Emission Historic Index and Frequency Spectrum of Reinforced Concrete under Accelerated Corrosion

AbstractThe main cause of degradation for reinforced concrete (RC) structures is the corrosion of the steel reinforcement. Laboratory tests aimed at studying durability are typically accelerated to provide usable results within a reasonable period of time, and well-established electrochemical techniques are used for the assessment of corrosion. However, because these techniques are not suitable for continuous monitoring and are often intrusive, nondestructive testing (NDT) techniques are also suitable for monitoring. Acoustic emission (AE) is one of the NDT techniques used to detect the onset and progression of corrosion. This paper presents an accelerated corrosion test setup and AE monitoring methodology based on the historic index, H(t), for laboratory experiments on RC specimens. Accelerated corrosion is attained by increasing the capillarity suction of RC exposed to chlorides. The frequency spectrum of the AE signals before and after the initiation of corrosion is investigated to isolate the frequenc.
The estrogen-induced advance in the cyclic LH surge in the rat: dependency on ovarian progesterone secretion.

In the 4-day cycling rat, injection of 20 μg of estradiol benzoate (EB) at 1230 on diestrus day 1 stimulates a 24-hr advance in the cyclic ovulatory LH surge, which then occurs between 1400 and 1900 on diestrus day 2. As a result, ovulation is also advanced 24 hr. Experiments were conducted to determine if this response depends on ovarian hormone secretion. Ovariectomy within one hour of EB injection on day 1 markedly diminished the magnitude of the LH surge on day 2 as compared to sham-ovariectomized controls. However, in similarly estrogenizedovariectomized rats, a supranormal LH surge was elicited by a 2.0 mg progesterone injection at 1200 on day 2. In additional experiments, ovarian progesterone secretion was measured at 1000 and 1300 on day 2 in untreated control rats and in rats receiving the EB injections. Progesterone secretion rates were significantly increased above normal values in the EB-treated rats. Together, these results suggest that the stimulatory feedback effects of estrogen injections .
Characterization of Bacillus isolates of potato rhizosphere from andean soils of Peru and their potential PGPR characteristics

Bacillus spp. are well known rhizosphere residents of many crops and usually show plant growth promoting (PGP) activities that include biocontrol capacity against some phytopatogenic fungi. Potato crops in the Andean Highlands of Peru face many nutritional and phytophatogenic problems that have a significant impact on production. In this context is important to investigate the natural presence of these microorganisms in the potato rhizosphere and propose a selective screening to find promising PGP strains. In this study, sixty three Bacillus strains isolated from the rhizosphere of native potato varieties growing in the Andean highlands of Peru were screened for in vitro antagonism against Rhizoctonia solani and Fusarium solani. A high prevalence (68%) of antagonists against R. solani was found. Ninety one percent of those strains also inhibited the growth of F. solani. The antagonistic strains were also tested for other plant growth promotion activities. Eighty one percent produced some level of the auxin indole-3-acetic acid, and 58% solubilized tricalcium phosphate. Phylogenetic analysis revealed that the majority of the strains belonged to the B. amyloliquefaciens species, while strains Bac17M11, Bac20M1 and Bac20M2 may correspond to a putative new Bacillus species. The results suggested that the rhizosphere of native potatoes growing in their natural habitat in the Andes is a rich source of Bacillus fungal antagonists, which have a potential to be used in the future as PGP inoculants to improve potato crop.