Miracle-dz/UniFAR-FTUs huggingface dataset:
Real-time Java processor optimized for RTSJ

Due to the preeminent work of the real-time specification for Java(RTSJ), Java is increasingly expected to become the leading programming language in real-time systems. To provide a Java platform suitable for real-time applications, a real-time Java processor can execute Java bytecode directly is proposed in this paper. This processor provides efficient support in hardware for mechanisms specified in the RTSJ and offers a simpler programming model through ameliorating the scoped memory of the RTSJ. The most important characteristic of the processor is that its WCET(worst case execution time) of the bytecode execution is predictable. It is vital for the real-time systems.
Pitaya Extracts Induce Growth Inhibition and Proapoptotic Effects on Human Cell Lines of Breast Cancer via Downregulation of Estrogen Receptor Gene Expression

Breast cancer is one of the most prevalent cancers in the world and is also the leading cause of cancer death in women. The use of bioactive compounds of functional foods contributes to reduce the risk of chronic diseases, such as cancer and vascular disorders. In this study, we evaluated the antioxidant potential and the influence of pitaya extract (PE) on cell viability, colony formation, cell cycle, apoptosis, and expression of BRCA1, BRCA2, PRAB, and Erα in breast cancer cell lines (MCF-7 and MDA-MB-435). PE showed high antioxidant activity and high values of anthocyanins (74.65 ± 2.18). We observed a selective decrease in cell proliferation caused by PE in MCF-7 (ER+) cell line. Cell cycle analysis revealed that PE induced an increase in G0/G1 phase followed by a decrease in G2/M phase. Also, PE induced apoptosis in MCF-7 (ER+) cell line and suppressed BRCA1, BRCA2, PRAB, and Erα gene expression. Finally, we also demonstrate that no effect was observed with MDA-MB-435 cells (ER−) after PE treatment. Taken together, the present study suggests that pitaya may have a protective effect against breast cancer.
Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability for infants with hypoxic-ischemic encephalopathy at 36 weeks’ or later gestation. To our knowledge, hypothermia trials have not been performed in infants presenting after 6 hours. Objective To estimate the probability that hypothermia initiated at 6 to 24 hours after birth reduces the risk of death or disability at 18 months among infants with hypoxic-ischemic encephalopathy. Design, Setting, and Participants A randomized clinical trial was conducted between April 2008 and June 2016 among infants at 36 weeks’ or later gestation with moderate or severe hypoxic-ischemic encephalopathy enrolled at 6 to 24 hours after birth. Twenty-one US Neonatal Research Network centers participated. Bayesian analyses were prespecified given the anticipated limited sample size. Interventions Targeted esophageal temperature was used in 168 infants. Eighty-three hypothermic infants were maintained at 33.5°C (acceptable range, 33°C-34°C) for 96 hours and then rewarmed. Eighty-five noncooled infants were maintained at 37.0°C (acceptable range, 36.5°C-37.3°C). Main Outcomes and Measures The composite of death or disability (moderate or severe) at 18 to 22 months adjusted for level of encephalopathy and age at randomization. Results Hypothermic and noncooled infants were term (mean [SD], 39 [2] and 39 [1] weeks’ gestation, respectively), and 47 of 83 (57%) and 55 of 85 (65%) were male, respectively. Both groups were acidemic at birth, predominantly transferred to the treating center with moderate encephalopathy, and were randomized at a mean (SD) of 16 (5) and 15 (5) hours for hypothermic and noncooled groups, respectively. The primary outcome occurred in 19 of 78 hypothermic infants (24.4%) and 22 of 79 noncooled infants (27.9%) (absolute difference, 3.5%; 95% CI, −1% to 17%). Bayesian analysis using a neutral prior indicated a 76% posterior probability of reduced death or disability with hypothermia relative to the noncooled group (adjusted posterior risk ratio, 0.86; 95% credible interval, 0.58-1.29). The probability that death or disability in cooled infants was at least 1%, 2%, or 3% less than noncooled infants was 71%, 64%, and 56%, respectively. Conclusions and Relevance Among term infants with hypoxic-ischemic encephalopathy, hypothermia initiated at 6 to 24 hours after birth compared with noncooling resulted in a 76% probability of any reduction in death or disability, and a 64% probability of at least 2% less death or disability at 18 to 22 months. Hypothermia initiated at 6 to 24 hours after birth may have benefit but there is uncertainty in its effectiveness. Trial Registration clinicaltrials.gov Identifier: NCT00614744
Words in Context: The Effects of Length, Frequency, and Predictability on Brain Responses During Natural Reading

Word length, frequency, and predictability count among the most influential variables during reading. Their effects are well-documented in eye movement studies, but pertinent evidence from neuroimaging primarily stem from single-word presentations. We investigated the effects of these variables during reading of whole sentences with simultaneous eye-tracking and functional magnetic resonance imaging (fixation-related fMRI). Increasing word length was associated with increasing activation in occipital areas linked to visual analysis. Additionally, length elicited a U-shaped modulation (i.e., least activation for medium-length words) within a brain stem region presumably linked to eye movement control. These effects, however, were diminished when accounting for multiple fixation cases. Increasing frequency was associated with decreasing activation within left inferior frontal, superior parietal, and occipito-temporal regions. The function of the latter region—hosting the putative visual word form area—was originally considered as limited to sublexical processing. An exploratory analysis revealed that increasing predictability was associated with decreasing activation within middle temporal and inferior frontal regions previously implicated in memory access and unification. The findings are discussed with regard to their correspondence with findings from single-word presentations and with regard to neurocognitive models of visual word recognition, semantic processing, and eye movement control during reading.
An External Capacitor-Less Ultralow-Dropout Regulator Using a Loop-Gain Stabilizing Technique for High Power-Supply Rejection Over a Wide Range of Load Current

An external capacitor-less ultra low-dropout (LDO) regulator that can continue to provide high power-supply rejection (PSR) over a wide range of the load current is proposed. Using the loop-gain stabilizer (LGS) to fix the dc level of the output voltage of the error amplifier to the optimal value, the LDO can keep maximizing the unity-gain frequency, while the load current changes widely up to 200 mA. Despite the multiple poles in the regulating loop, the stability can easily be obtained due to an intrinsic left-half plane zero, generated by the auxiliary path of the LGS. The proposed LDO was fabricated in a 40-nm CMOS process, and it had an input voltage of 1.1 V. When the dropout voltage was 0.1 V and the load current was 200 mA, the measured PSRs were −60 and −35 dB at 1 and 10 MHz, respectively. Due to the LGS, the dc loop gain was maintained to be high, resulting in good load and line regulations of <inline-formula> <tex-math notation="LaTeX">$19~\mu {\text{V}}$ </tex-math></inline-formula>/mA and 0.75 mV/V, respectively. While the total current consumption of the LDO was <inline-formula> <tex-math notation="LaTeX">$275~\mu {\text{A}}$ </tex-math></inline-formula>, the LGS consumed only <inline-formula> <tex-math notation="LaTeX">$7~\mu {\text{A}}$ </tex-math></inline-formula>. The area was 0.008 mm<sup>2</sup> with 4-pF on-chip capacitance for compensation.
Postural stability in a population of dancers, healthy non-dancers, and vestibular neuritis patients

Abstract Introduction: Several studies have indicated better balance control in dancers than in control participants, but some controversy remains. The aim of our study is to evaluate the postural stability in a cohort of dancers, non-dancers, compensated, and non-compensated unilateral vestibular neuritis (VN). Methods: This is a prospective study of control subjects, dancers, and VN patients between June 2009 and December 2015. Dancers from the Dance Conservatory of Madrid and VN patients were referred to our department for analysis. After the clinical history, neuro-otological examination, audiogram, and caloric tests, the diagnosis was done. Results from clinical examination were used for the categorization of compensation situation. A computerized dynamic posturography was performed to every subject. Results: Forty dancers and 38 women formed both ‘dancer’ and ‘normal’ cohorts. Forty-two compensated and 39 uncompensated patients formed both ‘compensated’ and ‘uncompensated’ cohorts. Dancers had significantly greater antero-posterior (AP) body sway than controls during condition 5 and 6 in the Sensory Organization Test (SOT) (p < .05). When we compared the uncompensated cohort with both control and dancers groups, we found significant greater body sway in every SOT studied condition (p < .05). While mean AP body say in SOT 5 and 6, showed greater values in compensated patients than the control group, the mean analysis did not show any statistical difference between the compensated and dancer groups, in such SOT conditions. Conclusions: Dancers demonstrated greater sways than non-dancers when they relied their postural control on vestibular input alone. Compensated patients had a similar posturographic pattern that the dancers cohort, suggesting a similar shift from visual to somatosensory information.
Comparison of traditional risk factors, natural history and angiographic findings between coronary heart disease patients with age <40 and >or=40 years old.

OBJECTIVE In this study we aimed to examine the angiographic findings, traditional risk factors and natural history of Turkish patients <40 and >or=40 years old with coronary heart disease (CHD). METHODS The records of 491 patients with stable angina pectoris or acute coronary syndrome (ACS), who had undergone coronary angiography (CAG) were reviewed. The patients <40 years (group 1) and >or=40 years (group 2) were compared. RESULTS The study population was classified as group 1 with 240 patients (mean age 35.7+/-3.4 years) and group 2 with 251 patients (mean age 61.0+/-9.7 years). Smoking, family history, hypercholesterolemia, hypertriglyceridemia and low levels of high-density lipoprotein cholesterol were more prevalent in group 1 while diabetes mellitus, hypertension was higher in group 2. The common presentation among <40 years patients was ACS whereas stable angina was the most common presentation in patients >or=40 years old. Patients in group 1 showed a preponderance of single-vessel disease whereas patients of group 2 showed dominance of multivessel disease. Early clinical course of patients with ACS in group 1 was better than in group 2. CONCLUSION Our study shows a significantly different clinical, angiographic and biochemical profile in <40 years patients with CHD compared with >or=40 years patients. Dominance of smoking and dyslipidemias that are the preventable risk factors in premature CHD patients is an important threat for our community health. Healthy life styles should be encouraged beginning from young ages and new precautions about smoking must be taken.
Feature model extraction from large collections of informal product descriptions

Feature Models (FMs) are used extensively in software product line engineering to help generate and validate individual product configurations and to provide support for domain analysis. As FM construction can be tedious and time-consuming, researchers have previously developed techniques for extracting FMs from sets of formally specified individual configurations, or from software requirements specifications for families of existing products. However, such artifacts are often not available. In this paper we present a novel, automated approach for constructing FMs from publicly available product descriptions found in online product repositories and marketing websites such as SoftPedia and CNET. While each individual product description provides only a partial view of features in the domain, a large set of descriptions can provide fairly comprehensive coverage. Our approach utilizes hundreds of partial product descriptions to construct an FM and is described and evaluated against antivirus product descriptions mined from SoftPedia.
ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma

Aldehyde dehydrogenase 1 family member L1 (ALDH1L1) is downregulated in hepatocellular carcinoma (HCC) tumors, and its decreased expression is associated with the poor prognosis of HCC patients. We, therefore, evaluated the effect of single nucleotide polymorphisms (SNPs) of ALDH1L1, and its mRNA expression on the survival of hepatitis B virus (HBV)-related HCC patients and the association with tumor protein p53 (TP53) expression. ALDH1L1 SNPs in 415 HBV-related HCC patients were genotyped via direct sequencing. Expression profile chip datasets and survival information were obtained from GSE14520. The C allele (CT/CC) carriers of rs2276724 were significantly associated with a favorable prognosis [adjusted P=0.040; adjusted hazard ratio (HR)=0.725; 95% confidence interval (CI)=0.533–0.986]. Joint-effect analyses suggested that the CT/CC genotype of rs2276724 in TP53-negative patients was significantly associated with a decreased risk of death, compared to the TT genotype of rs2276724 in TP53-positive patients (adjusted P=0.037; adjusted HR=0.621; 95% CI=0.396–0.973). Furthermore, low expression of ALDH1L1 predicted a poor prognosis for the HBV-related HCC patients (adjusted P=0.04 for disease-free survival; adjusted P=0.001 for overall survival). Patients with high ALDH1L1 expression and low TP53 expression were significantly associated with a decreased risk of recurrence and death, and patients with a high TP53 expression were also significantly associated with a decreased risk of death in HBV-related HCC, compared with low ALDH1L1 and low TP53 expression. Our results suggest that ALDH1L1 may be a biomarker for predicting postoperative clinical outcomes. Moreover, ALDH1L1-rs2276724 and mRNA expression were associated with TP53 expression in HBV-related HCC patients.
p53 immunohistochemistry in high‐grade urothelial carcinoma of the bladder is prognostically significant

TP53 mutations are characteristic of the high‐grade pathway in the dual pathway of urothelial carcinogenesis. These mutations have been correlated with aberrant accumulation of p53 protein; however the definition and significance of this vary in the literature. The aim of this study was to assess p53 immunostaining in a cohort of high‐grade urothelial carcinomas by using standard published cut‐offs and a novel binarized method that included assessment of the null phenotype. Each scoring method was correlated with oncological outcome.
Outage Probability Analysis of NOMA within Massive MIMO Systems

A Pseudo Double Scattering Channel (PDSC) Matrix assumption is proposed here for the downlink Non- Orthogonal Multiple Access (NOMA) within the massive Multi-Input Multi-Output (MIMO) systems. Afterwards, the outage probability analysis of such a system is investigated. That is, with the aid of random matrix and statistics theories, the Cumulative Probability Distribution (CDF) and also the outage probability performance are addressed. After that, the mathematics derivations obtained here are verified through numerical simulation results, wherein we further find out that with antenna number increasing, the system outage probability performance is reduced.
Assessment of safety culture among job positions in high-rise construction: a hybrid fuzzy multi criteria decision-making (FMCDM) approach

ABSTRACT The construction industry is known as one of the most dangerous industries, which not only requires sound operation of executive laws and regulations, but also necessitates the safety culture of all workers at workshops. Therefore, the aim of this research is to identify the factors of safety culture and ranking occupations in jobsites based on those factors in order to proactively improve the safety culture of construction projects and subsequently promote safety conditions and worksites. In this study, safety culture criteria are weighted by a combination of Fuzzy Decision Trail and Evaluation Laboratory and Fuzzy ANP methods. Next, different job positions in high-rise projects are ranked using the Fuzzy Technique for Order of Preference by Similarity to Ideal Solution method. Findings demonstrated that the project manager, site superintendent and supervisor occupations had the highest and labourers had the lowest level of safety culture in the high-rise construction industry. Furthermore, factors such as safety supervision and training must be considered more seriously in order to create a positive safety culture among workers.
The total ionizing dose effect on SiO 2 and new high-k gate dielectrics under gamma-ray irradiation

The total ionizing dose effect of Al 2 O 3 high-k dielectric under 60Co gamma-ray is studied and compared with that in SiO 2 and HfO 2 with the same equivalent oxide thickness. 60Co gamma irradiation give birth to oxide and interface trapped charge in the Al/Al 2 O 3 /Si MOS capacitor, the trapped charge density is in the range of 1011∼1012cm−2. The trapped charge would either be positive or negative depending on the radiation total dose and the bias condition. There is oxygen vacancies inside the Al 2 O 3 bulk and silicon dangling bonds on Al 2 O 3 /Si interface, and the amount of the silicon dangling bond increases with the radiation total dose. The Effective trapping efficiency in ALD Al 2 O 3 after 500krad is 31.5%, which is larger than thermally oxidized SiO 2 and ALD HfO2.
Differences in the Tensor Veli Palatini Between Adults With and Without Cleft Palate Using High-Resolution 3-Dimensional Magnetic Resonance Imaging

Objective: To investigate the dimensions of the tensor veli palatini (TVP) muscle in adults with and without cleft palate. Design: Prospective study. Participants: There were a total of 14 adult participants, 8 noncleft and 6 with cleft palate. Methods: Analysis and comparison of the TVP muscle and surrounding structures was completed using 3D MRI data and Amira 5.5 Visualization Modeling software. TVP muscle volume, hamular process distance, mucosal thickness, TVP muscle length, and TVP muscle diameter were used for comparison between participant groups based upon previous research methods. Results: Mann-Whitney U tests revealed a significantly smaller (U < .001, P = .002) TVP muscle volume in the cleft palate group (median = 536.22 mm3) compared to individuals in the non–cleft palate group (median = 895.19 mm3). The TVP muscle was also significantly shorter (U = 1.00, P = .003) in the cleft palate group (median = 18.04 mm) versus the non–cleft palate (median = 21.18 mm). No significant differences were noted for the other measured parameters. Conclusion: Significant differences in the TVP muscle volume and length among the noncleft participants found in this study may insights into the reported increased incidence of otitis media with effusion (OME) seen in the cleft population. Results from this study contribute to our understanding of the underlying anatomic differences among individuals with cleft palate.
Dietary Phytochemicals Promote Health by Enhancing Antioxidant Defence in a Pig Model

Phytochemical-rich diets are protective against chronic diseases and mediate their protective effect by regulation of oxidative stress (OS). However, it is proposed that under some circumstances, phytochemicals can promote production of reactive oxygen species (ROS) in vitro, which might drive OS-mediated signalling. Here, we investigated the effects of administering single doses of extracts of red cabbage and grape skin to pigs. Blood samples taken at baseline and 30 min intervals for 4 hours following intake were analyzed by measures of antioxidant status in plasma, including Trolox equivalent antioxidant capacity (TEAC) and glutathione peroxidase (GPx) activity. In addition, dose-dependent production of hydrogen peroxide (H2O2) by the same extracts was measured in untreated commercial pig plasma in vitro. Plasma from treated pigs showed extract dose-dependent increases in non-enzymatic (plasma TEAC) and enzymatic (GPx) antioxidant capacities. Similarly, extract dose-dependent increases in H2O2 were observed in commercial pig plasma in vitro. The antioxidant responses to extracts by treated pigs were highly correlated with their respective yields of H2O2 production in vitro. These results support that dietary phytochemicals regulate OS via direct and indirect antioxidant mechanisms. The latter may be attributed to the ability to produce H2O2 and to thereby stimulate cellular antioxidant defence systems.
Questionnaire and Behavioral Task Measures of Impulsivity are Differentially Associated With Body Mass Index: A Comprehensive Meta-Analysis

Although impulsivity has been implicated in the development and maintenance of obesity, evidence linking impulsivity to obesity has been mixed. These mixed findings may be related to differences in the type of impulsivity measures used and the varied domains of impulsivity assessed by each measure. The present meta-analysis aimed to examine the impact of measurement selection on the relationship between impulsivity and body mass index (BMI). A total of 142 articles met inclusion criteria and were comprised of 315,818 participants. Effect sizes consisted of Fisher’s z-transformed correlation coefficients, which were weighted by the inverse variance to establish the grand mean estimate of the relationship between impulsivity and BMI. Overall weighted mean effect sizes also were computed for each type and domain of impulsivity measure. Moderator analyses were conducted using a mixed-effects approach to determine if the relationship between impulsivity and BMI varied between the types of impulsivity measures used. On average, participants were 32.25 (SD = 12.41) years of age, with a BMI of 26.63 (SD = 5.73) kg/m2. The overall relationship between impulsivity and BMI was small but significant (r = .07). Behavioral task measures of impulsivity produced significantly larger effect sizes (r = .10) than did questionnaire measures of impulsivity (r = .05). Domains of impulsivity that assessed disinhibited behaviors (r = .10), attentional deficits (r = .11), impulsive decision-making (r = .10), and cognitive inflexibility (r = .17) produced significant effect sizes. These meta-analytic findings demonstrate that impulsivity is positively associated with BMI and further document that this association varies by the type of impulsivity measure used and the domain of impulsivity assessed.