Miracle-dz/UniFAR-FTUs huggingface dataset:
SHORT MEASURE OF PERSONALITY TIPI-P IN A POLISH SAMPLE

The paper presents the Polish adaptation of the Ten-Item Personality Inventory (TIPI-P), which is designed to measure five dimensions of personality as described in the Big Five model. The items were translated into Polish from the original English version. The equivalence of the two versions was confirmed in a study conducted on a sample of bilingual students. A series of four independent studies (on a total sample of over 500 students) were conducted to verify the psychometric properties of the Polish version of TIPI. They proved acceptable test-retest reliability of TIPI-P after two weeks. As in the original version of the inventory, the internal consistency coefficients are relatively low. Correlations between TIPI-P and NEO-FFI as well as between self-rating and peer-rating confirm the convergent and discriminant validity of TIPI-P scales. The results of the studies suggest that the Polish adaptation can be used in scientific research conducted on student samples.
Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation.

UNLABELLED Infiltration of human melanomas with cytotoxic immune cells correlates with spontaneous type I IFN activation and a favorable prognosis. Therapeutic blockade of immune-inhibitory receptors in patients with preexisting lymphocytic infiltrates prolongs survival, but new complementary strategies are needed to activate cellular antitumor immunity in immune cell-poor melanomas. Here, we show that primary melanomas in Hgf-Cdk4(R24C) mice, which imitate human immune cell-poor melanomas with a poor outcome, escape IFN-induced immune surveillance and editing. Peritumoral injections of immunostimulatory RNA initiated a cytotoxic inflammatory response in the tumor microenvironment and significantly impaired tumor growth. This critically required the coordinated induction of type I IFN responses by dendritic, myeloid, natural killer, and T cells. Importantly, antibody-mediated blockade of the IFN-induced immune-inhibitory interaction between PD-L1 and PD-1 receptors further prolonged the survival. These results highlight important interconnections between type I IFNs and immune-inhibitory receptors in melanoma pathogenesis, which serve as targets for combination immunotherapies. SIGNIFICANCE Using a genetically engineered mouse melanoma model, we demonstrate that targeted activation of the type I IFN system with immunostimulatory RNA in combination with blockade of immune-inhibitory receptors is a rational strategy to expose immune cell-poor tumors to cellular immune surveillance.
利他意願在調節負向情緒上的效果Effect of Altruism on the Regulation of Negative Emotion

本研究主要目的在探討利他意願對情緒的影響。 實驗一呈現兩篇不同內容的文章以探討閱讀對情緒 的影響。 研究結果顯示溫馨內容之文章可使閱讀者產生正向的情緒，災難內容之文章則使閱讀者產 生負向的情緒。 實驗二採用實驗一中所使用之災難內容的文章以使閱讀者產生負向情緒，然後請其 表達是否願意以捐款或擔任志工的方式幫助災民。 結果發現幾乎所有的參與者均願意伸出援手，而 和未被詢及助人意願之控制組相較之下，實驗組的負向情緒很明顯的比控制組的負向情緒低，此結 果顯示利他意願可以降低負向情緒。 本研究在教育上之應用於文中亦有所討論。 關鍵詞: 正向心理學、利他意願、情緒、閱讀 The effect of altruism on affect was examined in this study. In Experiment 1, two articles with different content were presented to participants. Results indicated that the article with kind and pleasant content produced positive affect while the one describing an earthquake disaster produced negative affect for the participants. In Experiment 2, the participants were first asked to read the same article about earthquake disaster in Experiment 1. Then they were asked if they would like to donate some money or to work as a volunteer to help the earthquake survivors. Participants who wished to help the survivors in Experiment 2 reported less negative affect than participants in Experiment 1 who read the same article. The hypothesis that willingness to help others produced a decrease in negative affect is confirmed. Implications for education are discussed. KEY WORDS: altruism, emotion, positive psychology, reading
Directly Derived Non-Hyper-Singular Boundary Integral Equations for Acoustic Problems, and Their Solution through Petrov-Galerkin Schemes

Novel non-hyper-singular (i.e., only strongly-singular) boundary-integral-equations for the gradients of the acoustic velocity potential, involv- ing only O(r −2 ) singularities at the surface of a 3-D body, are derived, for solving problems of acoustics governed by the Helmholtz differential equation. The gradients of the fundamental solution to the Helmholtz differential equation for the velocity potential, are used in this derivation. Several basic identities governing the fundamental solution to the Helmholtz differential equation for velocity potential, are also derived. Using these basic identities, the strongly singular integral equations for the potential and its gradients (denoted here as φ-BIE, and q-BIE, respectively), are rendered to be only weakly-singular (i.e., possessing singular- ities of O(r −1 ) at the surface of a 3-D body). These weakly-singular equations are denoted as R-φ-BIE, and R-q-BIE, respectively. General Petrov-Galerkin weak-solutions of R-φ-BIE, and R-q-BIE are discussed; and special cases of collocation-based boundary-element numerical approaches (denoted as BEM-R-φ-BIE, and BEM-R-q-BIE), as well as Symmetric Galerkin Boundary Element approaches (denoted as SGBEM- R-φ-BIE and SGBEM-R-q-BIE, respectively) are also presented. The superior accuracy and efficiency of the SGBEM-R-φ-BIE and SGBEM-R-q-BIE are illustrated, through examples involving acoustic radiation as well as scattering from 3-D bodies possessing smooth surfaces, as well as surfaces with sharp corners.
“Hedge Your Bets”: Technology’s Role in Young Gay Men’s Relationship Challenges

ABSTRACT Technology is playing an increasingly pervasive role among young gay men in the process of meeting potential romantic or sexual partners. We investigated challenges posed by technology related to young gay men’s relationships. Focus groups (n = 9) of young gay men aged 18–24 (n = 43) were transcribed verbatim, and thematic analysis was used to identify two major themes regarding challenges to relationship development and maintenance. Subthemes include unrealistic expectations of relationships, inauthentic self-presentation online, sexual primacy over romance, increased opportunities for infidelity, and jealousy. The implications of this study for sexual education and sexual health promotion are discussed.
Evidence for behavioural thermoregulation by the world's largest fish

Many fishes make frequent ascents to surface waters and often show prolonged surface swimming following descents to deep water. This affinity for the surface is thought to be related to the recovery of body heat lost at depth. We tested this hypothesis using data from time–depth recorders deployed on four whale sharks (Rhincodon typus). We summarized vertical movements into bouts of dives and classified these into three main types, using cluster analysis. In addition to day and night ‘bounce’ dives where sharks rapidly descended and ascended, we found a third type: single deep (mean: 340 m), long (mean: 169 min) dives, occurring in daytime with extremely long post-dive surface durations (mean: 146 min). Only sharks that were not constrained by shallow bathymetry performed these dives. We found a negative relationship between the mean surface duration of dives in the bout and the mean minimum temperature of dives in the bout that is consistent with the hypothesis that thermoregulation was a major factor driving use of the surface. The relationship broke down when sharks were diving in mean minimum temperatures around 25°C, suggesting that warmer waters did not incur a large metabolic cost for diving and that other factors may also influence surface use.
BRCA2 germline mutations in male breast cancer patients in the Polish population

Breast cancer is a rare disease in men. Germ‐line mutations in BRCA2 and androgen receptor (AR) genes are thought to be responsible for a proportion of male breast cancer cases. The present study was performed on a series of 37 consenting patients not selected for family history of breast/ovarian cancer. The entire coding region of the BRCA2 gene and two exons of the AR gene were analyzed for germ‐line mutations to evaluate the association between BRCA2 and AR genes and male breast cancer in Poland. We identified four frameshift mutations (11%) in exons 10, 11, 17 and 18, two of them were novel: 6495del3insC and 8457insA. Three missense unclassified variants (8%) of the BRCA2 gene were also identified. The frequencies of missense alterations were examined in a set of 200 chromosomes. No alteration of the AR gene was found. We did not observe much difference in clinicopathological features between carriers and non‐carriers of BRCA2 mutations. Five of 37 patients (14%) had a family history of breast cancer, in one first‐ or second‐degree relative, among the latter was one mutation carrier. The results of this study suggest that germ‐line BRCA2 mutations account for rather small proportion of male breast cancer in Poland. © 2001 Wiley‐Liss, Inc.
Presidential Address: Asset Price Dynamics with Slow‐Moving Capital

I describe asset price dynamics caused by the slow movement of investment capital to trading opportunities. The pattern of price responses to supply or demand shocks typically involves a sharp reaction to the shock and a subsequent and more extended reversal. The amplitude of the immediate price impact and the pattern of the subsequent recovery can reflect institutional impediments to immediate trade, such as search costs for trading counterparties or time to raise capital by intermediaries. I discuss special impediments to capital formation during the recent financial crisis that caused asset price distortions, which subsided afterward. After presenting examples of price reactions to supply shocks in normal market settings, I offer a simple illustrative model of price dynamics associated with slow-moving capital due to the presence of inattentive investors. Copyright (c) 2010 the American Finance Association.
Inflammatory responses of gingival epithelial cells stimulated with Porphyromonas gingivalis vesicles are inhibited by hop-associated polyphenols.

BACKGROUND Periodontitis is induced by an imbalance between bacterial virulence and host defense ability. Porphyromonas gingivalis, a predominant periodontal pathogen, triggers a series of host inflammatory responses that aggravate the destruction of periodontium. Thus, anti-inflammatory reagents are considered desirable for effective periodontal therapy. In the present study, we examined the inhibitory effects of hop bract polyphenol (HBP) on cellular inflammatory responses induced by P. gingivalis membrane vesicles. METHODS Immortalized human gingival epithelial cells were stimulated with P. gingivalis membrane vesicles, and the effects of HBP on mRNA expression of cyclooxygenase (COX)-2, interleukin (IL)-6 and -8, and matrix metalloproteinase (MMP)-1 and -3 were examined using real-time reverse transcription-polymerase chain reaction. RESULTS HBP inhibited the mRNA expression of COX-2, IL-6 and -8, and MMP-1 and -3 in a dose-dependent manner, whereas epigallocatechin gallate (a control polyphenol) inhibited COX-2 mRNA expression only. Following further fractionation of HBP to identify the effective components, 2-[(2-methylpropanoyl)-phloroglucinol]1-O-beta-D-glucopyranoside (MPPG) was identified as a significant anti-inflammatory element that completely inhibited the inflammatory mRNA induction. Kaempferol 3-O-beta-glucopyranoside (astragalin) also was found to have anti-inflammatory effects. CONCLUSIONS HBP is suggested to be a potent inhibitor of cellular inflammatory responses induced by P. gingivalis vesicles. Further, MPPG and astragalin, identified here as effective components of HBP, also may be useful for the prevention and/or attenuation of periodontitis.
Separate Functional Domains of Human MD-2 Mediate Toll-Like Receptor 4-Binding and Lipopolysaccharide Responsiveness 1

Cellular responses to LPS are mediated by a cell surface receptor complex consisting of Toll-like receptor 4 (TLR4), MD-2, and CD14. MD-2 is a secreted protein that interacts with the extracellular portion of TLR4. Site-directed mutagenesis was used to identify the regions of human MD-2 involved in its ability to bind TLR4 and confer LPS responsiveness. A separate region of MD-2 was found to mediate each function. MD-2 binding to TLR4 was dependent on Cys95 and Cys105, which might form an intramolecular disulfide bond. Hydrophilic and charged residues surrounding this area, such as R90, K91, D100, and Y102, also contributed to the formation of the TLR4-MD-2 complex. A different region of MD-2 was found to be responsible for conferring LPS responsiveness. This region is not involved in TLR4 binding and is rich in basic and aromatic residues, several of which cooperate for LPS responsiveness and might represent a LPS binding site. Disruption of the endogenous MD-2-TLR4 complex by expression of mutant MD-2 inhibited LPS responses in primary human endothelial cells. Thus, our data indicate that MD-2 interaction with TLR4 is necessary but not sufficient for cellular response to LPS. Either of the two functional domains of MD-2 can be disrupted to impair LPS responses and therefore represent attractive targets for therapeutic interventions.z
A metric for trusted systems

This paper proposes a model for quantifying and reasoning about trust in IT equipment. Trust is considered to be a subjective belief, and the model consists of a belief model and set of operators for combining beliefs. Security evaluation is being discussed as a method for determining trust. Trust may also be based on other types of evidence such as for example ISO 9000 certification, and the model can be used to quantify and compare the contribution to the total trust each type of evidence provides.
Social Class and Self-Esteem Among Children and Adults

The literature on the relationship of social class to self-esteem is riddled with contradictions, showing positive, null, and inverse relationships. Two studies examinig this relationship are compared-one, a sample of children aged 8-18; the other, a sample of adults aged 18-65. The results indicate virtually no association for younger children, a modest association for adolescents, and a moderate association for adults. Four principles of self-esteem development are advanced to account for these conditional relations-social comparison processes, reflected appraisals, self-perception theory, and psychological centrality. It is suggested that these principles apply equally to adults and children and that the identical principles help to explain why social class should have different effects on the self-esteem of children and adults.
Structure and dynamics of receptive fields in the visual cortex of the cat (area 18) and the influence of GABAergic inhibition

Receptive fields (RFs) in the visual cortex are characterized by spatiotemporal profiles that have been described in detail for area 17 simple cells. In this study, we analyse spatial and temporal RF properties of simple and complex cells in layer II/III of area 18 of the anaesthetized adult cat, using the reverse correlation method with brief 50 ms presentations of flashing bright and dark bars. Stimuli were presented with preferred orientation as previously determined by moving bars. Simple cell RFs were characterized by spatially and temporally separable ON and OFF subfields, while in complex cells ON and OFF subfields were superimposed. To discriminate possible contributions of GABAergic inhibition to RF structure and response dynamics in area 18, we have used three‐barrelled micropipettes for single cell recordings and microiontophoresis, and have documented ON and OFF responses before, during and after application of bicuculline methiodide for blockade of GABAA receptors. During blockade of GABAergic inhibition, the stimulus‐induced and resting discharge frequency increased, and in about 50% of the cells both ON and OFF subfields changed significantly in space and/or time in a reversible manner. In space, blockade of inhibition widened RF subfields, whereas in time, it shortened the duration of the excitatory cell response in simple and complex cells. ON and OFF subfields separated in space and time (simple cells), or time (complex cells) became less isolated or even superimposed. The results indicate substantial local inhibitory processing contributing to spatiotemporal RF properties in layers II/III of area 18 of the cat.
Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study

Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI. We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC). Thirty-four elderly outpatients meeting Petersen's MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham, 10 Hz rTMS at 110% of motor threshold, 2,000 pulses per session. Neuropsychological assessment at baseline, after the last session (10th) and at one-month follow-up, was applied. ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group. The improvement was kept after one month. Other neuropsychological tests were heterogeneous. rTMS at 10 Hz enhanced everyday memory in elderly with MCI after 10 sessions. These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.
The Role of Time in Learning

This literature review paper examined the role of time in students learning. It was comprehensive in nature, investigating time and its direct effect on learning as well as indirect relationships with factors including teacher use of time, student use of time, the effect of aptitude or intelligence on time and learning, the role of time on cognition, and the economics of time use according to models of economics. It was intended to determine to what extent time plays a role in learning and suggest possible ways to improve teaching practices based on findings. This paper reviewed 27 quantitative, two conceptual, and one qualitative study. The conclusion drawn from this review was that while time was demonstrated to be a factor in learning, its role was not major. There are other factors, such as the nature of the time used, the cognitive demand of classroom lessons, and the aptitude and interests of students, that play a more significant role in student learning.
Coaching Behaviors and Athlete Motivation: Female Softball Athletes’ Perspectives

Abstract Perspectives of female collegiate softball athletes (n = 41) attending universities (n = 25) in the United States classified as National Collegiate Athletic Association (NCAA) Division I teams, were examined in this study. Using Self-determination theory (SDT; Ryan & Deci, 2000) as a guide, structured interviews were conducted to assess athletes’ perspectives of head coach behaviors that influenced competence and motivation. Content analysis followed existential phenomenological interpretation methods and revealed three primary themes that influenced motivation: athletes’ perceived competence, coach-related factors (e.g., behaviors, strategies), and coach-athlete communication. Athletes acknowledge the head coach was a major influence on perceptions of competence. Perceptions of coach-athlete communication (including verbal communication) were the greatest influence on athlete motivation. Athletes were more motivated to perform when the head coach’s communication was clear and direct. Athletes’ motivation was most negatively influenced when the coach avoided communication or ignored athletes after a performance attempt. These findings are further explored as they relate to coaching interventions.
Multivesicular Release Differentiates the Reliability of Synaptic Transmission between the Visual Cortex and the Somatosensory Cortex

Neurons in layer 4 (L4) of the cortex play an important role in transferring signals from thalamus to other layers of the cortex. Understanding the fundamental properties of synaptic transmission between L4 neurons helps us gain a clear picture of how the neuronal network in L4 cooperates to process sensory information. In the present study, we have determined the underlying parameters that govern synaptic strength, such as quantal size, size of readily releasable vesicle pool, and release probability (Pr) of excitatory synaptic connections within L4 of the visual cortex (V1) and the somatosensory cortex (S1) in mice. Although only a single vesicle is released per release site under physiological conditions at V1 synapses, multivesicular release (MVR) is observed at S1 synapses. In addition, we observed a saturation of postsynaptic receptors at S1 synapses. Other synaptic properties are similar in both cortices. Dynamic clamp experiments suggest that higher Pr and MVR at S1 synapses lower the requirement of the number of synaptic inputs to generate postsynaptic action potentials. In addition, the slower decay of synaptic current and the intrinsic membrane properties of the postsynaptic neuron also contribute to the reliable transmission between S1 neurons.
Making Wald Tests Work for Cointegrated Var Systems

Wald tests of restrictions on the coefficients of vector autoregressive (VAR) processes are known to have nonstandard asymptotic properties for 1(1) and cointegrated systems of variables. A simple device is proposed which guarantees that Wald tests have asymptotic X2-distributions under general conditions. If the true generation process is a VAR(p) it is proposed to fit a VAR(p+l) to the data and perform a Wald test on the coefficients of the first p lags only. The power properties of the modified tests are studied both analytically and numerically by means of simple illustrative examples.
Adolescent and young adult response to fear appeals in anti‐smoking messages

Purpose – This paper aims to investigate the level of fear experienced by students aged 13 to 30 years, in response to different types of anti‐smoking fear appeals. It seeks to extend and validate Quinn et al.'s study by specifically comparing adolescent and young adult responses to fear appeals.Design/methodology/approach – A total of 548 useable questionnaires were collected via a self‐administered questionnaire based on established scales. Factor analysis, T tests and ANOVA were used to replicate Quinn et al.'s analysis of the data.Findings – The main results are consistent with previous findings that adolescents and non‐smokers experience more fear. Further, general health and factual appeals cause the most fear across all ages but adolescents were more fearful of factual appeals and social ostracism appeals than young adults possibly indicating that factual and social appeals are better targeted at adolescents than young adults. The results were broadly similar to Quinn et al.'s results.Practical imp.