Miracle-dz/UniFAR-FTUs huggingface dataset:
Nocturnal Reflux Episodes Following the Administration of a Standardized Meal. Does Timing Matter?

OBJECTIVES:Prospective evidence supporting lifestyle modifications, including avoidance of late evening meals, for gastroesophageal reflux disease (GERD) sufferers is lacking. The aim of this study was to determine the difference of supine esophageal acid exposure in patients consuming an early or late standard meal relative to bedtime.METHODS:This is a prospective, randomized unblinded crossover trial. Thirty-two patients with typical reflux symptoms were enrolled and randomized to consume a standard meal either at 6 h or 2 h prior to going to bed for 2 consecutive nights. Acid exposure was measured for 48-h using a Bravo wireless pH system. Reflux symptom frequency and severity were recorded.RESULTS:Thirty patients successfully completed the study (63% male, 70% white, mean age 46 [24–74], mean body mass index [BMI] 28 kg/m2 [18–40]). EGD revealed esophagitis in 37% and hiatal hernia (HH) in 47% of patients. Following the late evening meal, there was significantly more supine reflux (P = 0.002) when compared to the early meal. Significantly more supine reflux was also noted following the late evening meal in patients with HH, in overweight individuals (25 ≤ BMI ≤ 29.9), and those reporting heartburn as their chief complaint. Patients with esophagitis had more supine reflux following both the late and early evening meals. There was no significant difference in total symptom score between the 2 days.CONCLUSIONS:GERD patients consuming a late-evening meal had significantly greater supine acid reflux compared to when they consumed an early meal, especially in overweight patients, and in patients with esophagitis or HH. These findings support the recommendations to our GERD patients to eat dinner early and to lose weight.
High-Resolution Movement EEG Classification

The aim of the contribution is to analyze possibilities of high-resolution movement classification using human EEG. For this purpose, a database of the EEG recorded during right-thumb and little-finger fast flexion movements of the experimental subjects was created. The statistical analysis of the EEG was done on the subject's basis instead of the commonly used grand averaging. Statistically significant differences between the EEG accompanying movements of both fingers were found, extending the results of other so far published works. The classifier based on hidden Markov models was able to distinguish between movement and resting states (classification score of 94–100%), but it was unable to recognize the type of the movement. This is caused by the large fraction of other (nonmovement related) EEG activities in the recorded signals. A classification method based on advanced EEG signal denoising is being currently developed to overcome this problem.
Ontology-Based Textual Emotion Detection

Emotion Detection from text is a very important area of natural language processing. This paper shows a new method for emotion detection from text which depends on ontology. This method is depending on ontology extraction from the input sentence by using a triplet extraction algorithm by the OpenNLP parser, then make an ontology matching with the ontology base that we created by similarity and word sense disambiguation. This ontology base consists of ontologies and the emotion label related to each one. We choose the emotion label of the sentence with the highest score of matching. If the extracted ontology doesn’t match any ontology from the ontology base we use the keyword-based approach. This method doesn’t depend only on keywords like previous approaches; it depends on the meaning of sentence words and the syntax and semantic analysis of the context.
Imaging , Diagnosis , Prognosis Loss of 18 q 22 . 3 Involving the Carboxypeptidase of Glutamate-like Gene Is Associated with Poor Prognosis in Resected Pancreatic Cancer

Purposes: Pancreatic cancer is the fourth leading cause of cancer-related death, and studies on the clinical relevance of its genomic imbalances are warranted. ExperimentalDesign:Recurrent copynumber alterations of cytobands and geneswere analyzedby array comparative genomic hybridization (aCGH) in 44 resected pancreatic cancer specimens. Prognostic markers identified by aCGH were validated by PCR gene copy number assay in an independent validation cohort of 61 resected pancreatic cancers. The functions of gene identified were evaluated by proliferation, cell cycle, and migration assays in pancreatic cancer cells. Results: We showed recurrent copy number gains and losses in the first cohort. Loss of 18q22.3 was significantly associated with short-term overall survival in the first cohort (P 1⁄4 0.019). This cytoband includes the carboxypeptidase of glutamate-like (CPGL) gene. CPGL gene deletion was associated with shorter overall survival in the validation cohort (P1⁄4 0.003). CPGL deletion and mutations of TP53 or Kras seem to be independent events. A Cox model analysis of the two cohorts combined showed that loss of 18q22.3/deletion of the CPGL gene was an independent poor prognostic factor for overall survival (HR 1⁄4 2.72, P 1⁄4 0.0007). Reconstitution of CPGL or its splicing variant CPGL-B into CPGL-negative pancreatic cancer cells attenuated cell growth, migration, and induced G1 accumulation. Conclusion: Loss of 18q22.3/deletion of the CPGL gene is a poor prognostic marker in resected pancreatic cancer, and functional studies suggest the CPGL gene as growth suppressor gene in pancreatic cancer. Clin Cancer Res; 18(2); 524–33. 2011 AACR.
Aberrant BAF57 Signaling Facilitates Prometastatic Phenotypes

Purpose: BAF57, a component of the switching-defective and sucrose nonfermenting (SWI/SNF) chromatin-remodeling complex conglomerate, modulates androgen receptor activity to promote prostate cancer. However, the molecular consequences of tumor-associated BAF57 expression have remained undefined in advanced disease such as castration-resistant prostate cancer and/or metastasis. Experimental Design: Clinical human specimens of primary and metastatic prostate cancer were immunohistochemically examined for tumor-grade association of BAF57 expression. Global gene expression analyses were conducted in models mimicking tumor-associated BAF57 expression. Aberrant BAF57-dependent gene expression changes, bypass of androgen-mediated signaling, and chromatin-specific SWI/SNF complex alterations with respect to cytoskeletal remodelers such as integrins were validated. Cell migration assays were used to profile the biologic phenotypes conferred under conditions simulating tumor-derived BAF57 expression. Results: Immunohistochemical quantitation of primary human specimens revealed that BAF57 was significantly and aberrantly elevated as a function of tumor grade. Critically, gene expression analyses showed that BAF57 deregulation circumvented androgen-mediated signaling, elicited α2 integrin upregulation, and altered other SWI/SNF complex components at the α2 integrin locus. BAF57-dependent α2 integrin induction conferred a prometastatic migratory advantage, which was attenuated by anti-α2 integrin antibody blockade. Furthermore, BAF57 was found to be markedly upregulated in human prostate cancer metastases of the lung, lymph node, and dura. Conclusion: The findings herein, identifying tumor-associated BAF57 perturbation as a means to bypass androgen-signaling events that facilitate novel prometastatic phenotypes, link BAF57 upregulation to tumor dissemination. These data thereby establish BAF57 as a putative marker of metastatic potential that could be leveraged for therapeutic intervention. Clin Cancer Res; 19(10); 2657–67. ©2013 AACR.
Phylogenetic Analysis of an Anaerobic, Trichlorobenzene-Transforming Microbial Consortium

ABSTRACT A culture-independent phylogenetic survey for an anaerobic trichlorobenzene-transforming microbial community was carried out. Small-subunit rRNA genes were PCR amplified from community DNA by using primers specific for Bacteria or Euryarchaeotaand were subsequently cloned. Application of a new hybridization-based screening approach revealed 51 bacterial clone families, one of which was closely related to dechlorinating Dehalobacter species. Several clone sequences clustered to rDNA sequences obtained from a molecular study of an anaerobic aquifer contaminated with hydrocarbons and chlorinated solvents (Dojka et al., Appl. Env. Microbiol. 64:3869–3877, 1998).
Twist-1 Induces Ezh2 Recruitment Regulating Histone Methylation along the Ink4A/Arf Locus in Mesenchymal Stem Cells

ABSTRACT The main impairment to tissue maintenance during aging is the reduced capacity for stem cell self-renewal over time due to senescence, the irreversible block in proliferation. We have previously described that the basic helix-loop-helix (bHLH) transcription factor Twist-1 can greatly enhance the life span of bone marrow-derived mesenchymal stem/stromal cells (MSCs). In the present study, we show that Twist-1 potently suppresses senescence and the Ink4A/Arf locus with a dramatic decrease in the expression of p16 and to some extent a decrease in p14. Furthermore, the polycomb group protein and histone methyltransferase Ezh2, which suppresses the Ink4A/Arf locus, was found to be induced by Twist-1, resulting in an increase in H3K27me3 along the Ink4A/Arf locus, repressing transcription of both p16/p14 and senescence of human MSCs. Furthermore, Twist-1 inhibits the expression of the bHLH transcription factor E47, which is normally expressed in senescent MSCs and induces transcription of the p16 promoter. Reduced Twist-1 wild-type expression and function in bone cells derived from Saethre-Chotzen patients also revealed an increase in senescence. These studies for the first time link Twist-1 to histone methylation of the Ink4A/Arf locus by controlling the expression of histone methyltransferases as well as the expression of other bHLH factors.
Hybrid BAW/SAW AlN and AlScN thin film resonator

A novel type of hybrid resonator based on BAW transformation into SAW in a ridged layered structure was fabricated and characterized. Bulk waves are excited by micromachined piezoelectric AlScN pillars located on the non-piezoelectric Si and sapphire substrates. The effect of film thickness and etching depth on the electromechanical coupling and velocity dispersion were calculated by finite element simulation. Resonators of various geometries were fabricated. Maximum effective coupling coefficient of 3.8% was achieved with a 3 um thick Al0.85Sc0. 15N film on a sapphire substrate.
Effect of compliance with recommended calf-rearing practices on control of bovine Johne's disease.

OBJECTIVE To assess the degree of compliance with recommended management procedures for the control of bovine Johne's disease and study the relationship between aspects of calf management and testing/disease outcomes in the herds. PROCEDURE Fifty-four south Gippsland dairy herds participating in the Victorian bovine Johne's disease test and control program were visited between July and November 2002 and an audit of calf rearing practices was conducted. The results of testing completed under the program were analysed for each of the herds. Twenty seven management factors were examined for a relationship with the presence of clinical cases of Johne's disease or cattle with positive ELISA test results that were born after the completion of the second whole herd test. Logistic regression was used to examine the strength of relationships between the management practices and the frequency with which new cases of Johne's disease arose. RESULTS AND CONCULSIONS: Calves were removed from their dams within 12 hours of birth in only 17 (31.5%) of the herds. However, in all but one herd the calves were removed within 24 hours of birth. In 42 herds (77.8%) calf rearing facilities were adequately separated from adult cattle and the faeces from adult cattle. In 41 herds (75.9%) calves up to the age of 12 months were grazed on paddocks that were free of manure or effluent from adult cattle. However, in only 10 (18.5%) of the herds were all three of these calf management practices applied. Feeding whole milk containing antibiotic residues, or providing water for calves from birth, were found to have statistically significant associations with an increased occurrence of cases of bovine Johne's disease in the study herds. The practice of allowing cows to calve in a paddock was found to be associated with reduced occurrence of bovine Johne's disease. These associations were still found after analysis that included herd size, the number of clinical cases that had occurred in the herds before the start of testing, the number of animals with positive ELISA tests that were detected at the first test and the number of years of participation in the test and cull program. Early separation of newborn calves from cows and grazing calves under 12 months of age in areas free of adult cattle were not found to be protective against Johne's disease.
Inhibition and reappraisal within emotional disclosure: the embodying of narration

The emotional disclosure paradigm (EDP) associates better health with repeated disclosure of emotional experiences. However, disclosure does not bring health benefits for all, and neither does the EDP adequately specify embodied mechanisms or neural pathways whereby benefits might be produced. This paper addresses these issues by offering more sophisticated notions of emotional inhibition and cognitive reappraisal. It then outlines aspects of the somatic marker hypothesis which supports a more comprehensive conceptualization of the processes that may enable both the positive and negative health effects of disclosure.
The Effect of an Application Performance Modelling Tool

One of the most important metrics of machine efficiency in HPC is job turnaround time, which is the time taken for a user to submit a job and recieve their results. This time consists of two primary components; run-time, which depends on the resources allocated to the job, and queue wait time, which is dependent on the resources requested and the present level of machine usage. This paper investigates the effect of applying application performance modelling techniques to producing run-time estimates for jobs to be scheduled on parallel High Performance Computing systems. Our aim through the development of such tools is to improve turnaround time for jobs across the system. This investigation is performed from the perspective of a community of HPC users who would make use of a tool to assist in job submission. We implement and validate a higher performance implementation of the scheduling algorithm used by the Maui scheduler and demonstrate that it matches the behaviour of an existing Maui configuration. We formulate a method for generating potential performance model results and use it to to modify three workloads from production supercomputers to include generated performance model wall-time estimates. We then apply the scheduling simulator to the workloads in order to simulate the effect of using of such a tool for the three real workloads. Examining the results from the simulation, we show a randomly selected sample set of tool users obtaining and improvement of upto 23% in average queuing time, and conclude that a tool that uses performance models to generate improved wall-time estimates would be beneficial to users of HPC systems.
No Major Role for Insulin-Degrading Enzyme in Antigen Presentation by MHC Molecules

Antigen presentation by MHC class I molecules requires degradation of epitope source proteins in the cytosol. Although the preeminent role of the proteasome is clearly established, evidence suggesting a significant role for proteasome-independent generation of class I ligands has been reported repeatedly. However, an enzyme responsible for such a role has not been identified. Recently insulin-degrading enzyme (IDE) was shown to produce an antigenic peptide derived from the tumor antigen MAGE-A3 in an entirely proteasome-independent manner, raising the question of the global impact of IDE in MHC class I antigen processing. Here we report that IDE knockdown in human cell lines, or knockout in two different mouse strains, has no effect on cell surface expression of various MHC class I molecules, including allomorphs such as HLA-A3 and HLA-B27 suggested to be loaded in an at least a partly proteasome-independent manner. Moreover, reduced or absent IDE expression does not affect presentation of five epitopes including epitopes derived from beta amyloid and proinsulin, two preferred IDE substrates. Thus, IDE does not play a major role in MHC class I antigen processing, confirming the dominant and almost exclusive role of the proteasome in cytosolic production of MHC class I ligands.
Implantation of a Dual Chamber Pacing and Sensing Single Pass Defibrillation Lead

GRADAUS, R. , et al.: Implantation of a Dual Chamber Pacing and Sensing Single Pass Defibrillation Lead. Dual‐chamber ICDs are increasingly used to avoid inappropriate shocks due to supraventricular tachycardias. Additionally, many ICD patients will probably benefit from dual chamber pacing. The purpose of this pilot study was to evaluate the intraoperative performance and short‐term follow‐up of an innovative single pass right ventricular defibrillation lead capable of bipolar sensing and pacing in the right atrium and ventricle. Implantation of this single pass right ventricular defibrillation lead was successful in all 13 patients (age 63 ± 8 years; LVEF 0.44 ± 0.16; New York Heart Association [NYHA] 2.4 ± 0.4, previous open heart surgery in all patients). The operation time was 79 ± 29 minutes, the fluoroscopy time 4.7 ± 3.1 minutes. No perioperative complications occurred. The intraoperative atrial sensing was 1.7 ± 0.5 mV, the atrial pacing threshold product was 0.20 ± 0.14 V/ms (range 0.03–0.50 V/ms). The defibrillation threshold was 8.8 ± 2.7 J. At prehospital discharge and at 1‐month and 3‐month follow‐up, atrial sensing was 1.9 ± 0.9, 2.1 ± 0.5, and 2.7 ± 0.6 mV, respectively, (P = NS, P < 0.05, P < 0.05 to implant, respectively), the mean atrial threshold product 0.79, 1.65, and 1.29 V/ms, respectively. In two patients, an intermittent exit block occurred in different body postures. All spontaneous and induced ventricular arrhythmias were detected and terminated appropriately. Thus, in a highly selected patient group, atrial and ventricular sensing and pacing with a single lead is possible under consideration of an atrial pacing dysfunction in 17% of patients.
Motivation for physical culture as factor of students' functional state optimization.

Purpose: to analyze students’ attitude to physical education classes; to compare motivation for physical education of 1 st and 4 th year students. Material: 100 students of 17 - 22 years’ age participated in the research. All they were questioned. Results: In the whole, boys have positive attitude to sport practicing but some of them can have harmful habits. The attitude to sport practicing of most of girls changes with age. It was found that biological age of students significantly exceeds passport age. Biological age of senior students it reduces to some extent, in comparison with junior students. It was also found that in process of studying at HEE students’ motivation for sport practicing changes to positive side. It witnesses about formation of student positive attitude to physical education in general. Conclusions: we have shown that there is a demand in strengthening of motivation for physical culture classes and further formation positive attitude to them with increasing of students’ knowledge about physical education.
A direct demonstration of functional specialization in human visual cortex

We have used positron emission tomography (PET), which measures regional cerebral blood flow (rCBF), to demonstrate directly the specialization of function in the normal human visual cortex. A novel technique, statistical parametric mapping, was used to detect foci of significant change in cerebral blood flow within the prestriate cortex, in order to localize those parts involved in the perception of color and visual motion. For color, we stimulated the subjects with a multicolored abstract display containing no recognizable objects (Land color Mondrian) and contrasted the resulting blood flow maps with those obtained when subjects viewed an identical display consisting of equiluminous shades of gray. The comparison identified a unique area (area V4) located in the lingual and fusiform gyri of the prestriate cortex. For motion, blood flow maps when subjects viewed moving or stationary black and white random-square patterns were contrasted. The comparison identified a unique area located in the region of the temporo-parieto-occipital junction (area V5). We thus provide direct evidence to show that, just as in the macaque monkey, different areas of the human prestriate visual cortex are specialized for different attributes of vision. The striate cortex (V1) and the contiguous visual area (V2), which in the monkey brain feed both the homologous areas, were active in all 4 conditions. This pattern of activity allowed us to use an extension of the approach to assess the functional relationship between the 3 areas during color and motion stimulation. This is based on an hypothesis-led analysis of the covariance structure of the blood flow maps and promises to be a powerful tool for inferring anatomical pathways in the normal human brain. (ABSTRACT TRUNCATED AT 250 WORDS)
The Arabs and Swahili Culture

Opening Paragraph Swahili culture can be roughly defined as the culture of the Swahili-speaking peoples of the East African coast whose activities show features of Perso-Arabian origin, features that are foreign to the culture of other Bantu peoples of East Africa. It cannot be described simply as Bantu culture plus Perso-Arabian elements, for some Swahilis have excluded from their way of life anything that can be labelled as Bantu; they may have Bantu blood, but their whole way of life is Muslim-Arabic. Résumé LES ARABES ET LA CULTURE SWAHILIE On a récemment fait ressortir pour des raisons politiques la distinction existant entire les Arabes et les Africains de la côte orientale d'Afrique, mais ils pourraient chacun de leur côté se réclamer fortement d'être des Swahilis. Les premiers immigrants perso-arabes en Afrique de l'Est furent englobés par la majorité africaine, les preuves d'une influence et d'une culture perso-arabe anciennes étant marginales et peu importantes. On est arrivé à la conclusion que le calendrier persan en Afrique de l'Est nʼa jamais eu beaucoup d'utilité pour le cultivateur africain. Cʼest après la période portugaise, avec les Hadrami et les Omani que l'influence arabe acquiert de l'importance. Les principales différences entre ces deux peuples sont esquissées. Les conséquences du déclin des Omani à Zanzibar sont examinées, spécialement en ce qui concerne la langue swahilie.