Miracle-dz/UniFAR-FTUs huggingface dataset:
A cloned major histocompatibility complex-restricted trinitrophenyl- reactive human helper T cell line that activates B cell subsets via two distinct pathways

A cloned, trinitrophenyl (TNP)-specific helper T cell line (TCL), termed E-11, has been established in long-term, interleukin 2-dependent culture and used to study human T helper (Th)-B cell collaboration. Co- culture of E-11 with TNP-modified, but not unmodified or FITC-modified, autologous B cells results in a vigorous, polyclonally plaque-forming cell (PFC) response. E-11 helper activity is not constitutive, but requires antigen-specific, major histocompatibility complex-restricted activation of the TCL cells by interaction with TNP-modified autologous or DR 5+ allogeneic macrophages. Using B cell subsets isolated by discontinuous density gradient cengrifugation as responder populations, we determined that E-11 activates B cell subsets via two distinct mechanisms: (a) E-11 polyclonally activates large B cells in an unrestricted and nonspecific manner; and (b) E-11 preferentially induces a PFC response by TNP-modified small B cells. These results suggest that the large B cell subset is activated by helper signals generated during the Th-antigen-presenting cell interaction, while small B cells require an additional stimulus that is provided by antigen-specific Th-B cell contact.
Position control of mobile two wheeled inverted pendulum robot by sliding mode control

Mobile two wheeled inverted pendulum (TWIP) robot is one type of mobile robot that have a number of advantages. Because dynamics of a TWIP is a complex nonlinear form, several studies have linearized the dynamic equation at the equilibrium point and designed a controller with linear dynamic equation. The limitation of the approach is, because of ignoring a high order term, the performance of that controller cannot be guaranteed at a point far from equilibrium. This paper discusses the modeling of TWIP systems and shows a new control method with nonlinear dynamics.
Being prepared in a sparse world: The case of KNN graph construction

K-Nearest-Neighbor (KNN) graphs have emerged as a fundamental building block of many on-line services providing recommendation, similarity search and classification. Constructing a KNN graph rapidly and accurately is, however, a computationally intensive task. As data volumes keep growing, speed and the ability to scale out are becoming critical factors when deploying a KNN algorithm. In this work, we present KIFF, a generic, fast and scalable KNN graph construction algorithm. KIFF directly exploits the bipartite nature of most datasets to which KNN algorithms are applied. This simple but powerful strategy drastically limits the computational cost required to rapidly converge to an accurate KNN solution, especially for sparse datasets. Our evaluation on a representative range of datasets show that KIFF provides, on average, a speed-up factor of 14 against recent state-of-the art solutions while improving the quality of the KNN approximation by 18%.
Criminal history and social disadvantage as predictors of the severity of violent offending

ABSTRACT Lethal violence is often seen as the tip of the iceberg and homicide perpetrators are seen as manifesting the most extreme number of various risk factors. This article explores whether that is the case. Using a unique data set combining data from several administrative registers with a nationally representative sample of different types of police-reported violence committed during 2010–2011 (N = 26,303 offenders) in Finland, we compare the offenders of five different types of violence (minor assault, assault, aggravated assault, attempted homicide, and completed homicide). In addition, we examine the association between the severity of violence and prior criminal history and different types of strain. The results give partial support to the hypothesis: the more serious the violence, the more crime prone and socially disadvantaged the offender. Yet, lethal offenders do not stand out alone; the division, rather, appears to be between offenders of serious (aggravated assault, attempted homicide, completed homicide) and less serious (minor assault, assault) forms of violence.
Iterative Properties of Birational Rowmotion II: Rectangles and Triangles

Birational rowmotion — a birational map associated to any finite poset $P$ — has been introduced by Einstein and Propp as a far-reaching generalization of the (well-studied) classical rowmotion map on the set of order ideals of $P$. Continuing our exploration of this birational rowmotion, we prove that it has order $p+q$ on the $\left( p, q\right) $-rectangle poset (i.e., on the product of a $p$-element chain with a $q$-element chain); we also compute its orders on some triangle-shaped posets. In all cases mentioned, it turns out to have finite (and explicitly computable) order, a property it does not exhibit for general finite posets (unlike classical rowmotion, which is a permutation of a finite set). Our proof in the case of the rectangle poset uses an idea introduced by Volkov (arXiv:hep-th/0606094) to prove the $AA$ case of the Zamolodchikov periodicity conjecture; in fact, the finite order of birational rowmotion on many posets can be considered an analogue to Zamolodchikov periodicity. We comment on suspected, but so far enigmatic, connections to the theory of root posets.
When a Red Herring in Not a Red Herring: Using Compositional Methods to Detect Non-Compositional Phrases

Non-compositional phrases such as red herring and weakly compositional phrases such as spelling bee are an integral part of natural language (Sag, 2002). They are also the phrases that are difficult, or even impossible, for good compositional distributional models of semantics. Compositionality detection therefore provides a good testbed for compositional methods. We compare an integrated compositional distributional approach, using sparse high dimensional representations, with the ad-hoc compositional approach of applying simple composition operations to state-of-the-art neural embeddings.
Rethinking the relationship between pedagogy, technology and learning in health and physical education

This paper seeks to address two key questions: (1) how could a pedagogically driven approach to the use of DigiTech in health and physical education (HPE) benefit young people’s learning and (2) what steps are required to develop new DigiTech pedagogies? The paper is a response to the largely pessimistic views presented in this journal by Gard, Lupton and Williamson about the role of technology in HPE. In this paper, we argue that while we need to be aware of the risks, we also need to explore the opportunities for digital technologies (DigiTech) to shape HPE in new and positive ways. Specifically, we argue that a focus on pedagogy is largely missing from earlier discussions. In mapping the evidence-base on DigiTech against a three-dimensional categorisation of pedagogy – in the form of learners and learning, teachers and teaching, and knowledge and context [Armour, K. M. (Ed.). (2011). Sport pedagogy: An introduction for coaching and teaching sport. Harlow: Prentice Hall] – we are able to demonstrate the value of a pedagogically informed debate on this topic. The paper concludes by arguing for a ‘profession-wide’ debate to co-construct, trial and evaluate new ways in which we should – and should not – use DigiTech to optimise young people’s learning in HPE.
Multilatinas and value creation from cross-border acquisitions:: an event study approach

Abstract The central proposition of this paper is to assess the performance of cross-border acquisitions made by Multilatinas. Applying the event study method to a sample of 607 announcements of acquisitions during the period 1989-2011 by 182 Multilatinas from Argentina, Brazil, Chile, Colombia, Mexico, Peru and Venezuela, we conclude that: (a) on average, these announcements have a neutral impact on the short-term returns to acquiring companies’ shareholders; (b) cross-sectional analysis reveals that relative size of the deals have a negative and significant effect on investors’ reactions and; (c) unlike the institutional distance between home and host countries, cultural distance matters, since it has a negative and significant effect on the perceptions that investors have regarding the expected economic impact of acquirers’ cross-border merger and acquisition (MA and (b) contribute to strategy, international business and M&A theories and practice.
Accounting for Patterns of Wealth Inequality

The life-cycle model is a standard theoretical framework for studying savings and wealth inequality. This paper shows that life-cycle models have difficulties accounting for the empirical relationship between lifetime earnings and household wealth. Quantitative life-cycle models imply a far tighter relationship between earnings and wealth than is observed in U.S. data. As a result, life-cycle models greatly overstate wealth differences between earnings rich and earnings poor households while at the same time underpredicting wealth inequality among households with similar lifetime earnings. Incorporating several features thought to be important for understanding wealth inequality, in particular bequests and entrepreneurship, does not improve the model's ability to account for the data. These findings suggest that standard life-cycle theory fails to account for an important source of wealth inequality.
A Strategy to Reduce Heart Failure Readmissions and Inpatient Costs

Background The objective of this study was to evaluate the effect of a disease management intervention on rehospitalization rates in hospitalized heart failure (HF) patients. Methods Patients treated with the TEACH-HF intervention that included Teaching and Education, prompt follow-up Appointments, Consultation for support services, and Home follow-up phone calls (TEACH-HF) from January 2010 to January 2012 constituted the intervention group (n = 548). Patients treated from January 2007 to January 2008 constituted the usual care group (n = 485). Results Group baseline characteristics were similar with 30-day readmission rates significantly different (19% usual care vs. 12% for the intervention respectively (P = 0.003)). Patients in the usual care group were 1.5 times more likely to be hospitalized (95% CI: 1.2 - 1.9; P = 0.001) compared to the intervention group. A savings of 641 bed days with potential revenue of $640,000 occurred after TEACH-HF. Conclusions The TEACH-HF intervention was associated with significantly fewer hospital readmissions and savings in bed days.
Predictors of worsening renal function in adult patients with congestive heart failure receiving recombinant human B-type brain natriuretic peptide (nesiritide).

BACKGROUND A recent meta-analysis suggested that the use of nesiritide (NES), a new agent for the treatment of congestive heart failure (CHF), is associated with an increased risk of acute renal failure (ARF). METHODS We examined this issue among 219 consecutive CHF patients, and determined the risk factors for development of ARF [defined as a rise in serum creatinine (SCr) >0.3 mg/dl]. The sole primary outcome was the development of ARF. RESULTS Seventy one of 219 patients received NES. There was no difference in ARF between patients receiving vs not receiving NES (29 vs 20%, P = 0.17). Evaluation of the entire cohort employing forward stepwise regression analysis revealed the following independent predictors of ARF: admission blood urea nitrogen (BUN) [P = 0.0004, odds ratio (OR) = 1.026], and admission brain natiuretic peptide (P = 0.04, OR = 1.0003). We repeated the same analysis for the subgroups of patients receiving or not receiving NES. For patients not receiving NES (n = 148), ARF developed in 30 (20%), with lower estimated glomerular filtration rate and older age being independent predictors. For patients receiving NES (n = 71), ARF developed in 21 (29%), with hypertension, elevated BUN/SCr ratio, and lack of use of angiotensin inhibitors being independent predictors. CONCLUSION Among all patients with CHF, the use of NES was not an independent risk factor for the development of ARF. However, risk factors for developing ARF differed among patients receiving vs not receiving NES. Comparison of these differing factors suggests that administering NES in the setting of diminished renal perfusion and/or altered renal autoregulation may confer an increased risk of ARF.
An Abductive Approach for Handling Inconsistencies in SCR Specifications

We present a formal approach for handling inconsistencies in Software Cost Reduction (SCR) specifications. The approach uses an event-based logic, called the Event Calculus , to represent SCR mode transition tables. Building on this formalism, the approach provides an abductive reasoning mechanism that enables the analysis of inconsistencies between SCR mode transition tables and global requirements (invariants), and the identification of alternative changes that would resolve such inconsistencies. Changes include addition of new invariants, refinement of existing invariants, and changes on conditions of mode transitions. The methodology is widely applicable, in particular to systems embedded in complex environments whose initial conditions cannot be completely predicted. A case study of an automobile cruise control system is used to illustrate our approach. The technique described is implemented using existing tools for abductive logic programming.
PERSEPSI MAHASISWA AKUNTANSI TERHADAP NIAT MELAKUKANWHISTLEBLOWING(Studi Pada Perguruan Tinggi di Bandar Lampung)

Penelitian ini bertujuan untuk menganalisis persepsi mahasiswa akuntansi terhadap niat melakukan whistleblowing. Penelitian ini menggunakan kuesioner untuk mengumpulkan informasi yang dibutuhkan. Variabel yang digunakan dalam penelitian ini yaitu Persepsi Tentang Norma Subyektif, Sikap Terhadap Perilaku, Persepsi Tentang Kontrol Perilaku, Jenis Kelamin, dan Tingkat Indeks Prestasi Kumulatif sebagai variabel independen dan Niat sebagai variabel dependen. Penelitian ini menggunakan teknik purposive sampling dalam pengumpulan data. Total sampel dalam penelitian ini sebanyak 330 sampel. Responden dalam penelitian ini adalah mahasiswa akuntansi Universitas Lampung, Universitas Bandar Lampung, Universitas Malahayati, Universitas Mitra Lampung, STIE Prasetya Mandiri A2L, dan STIE Gentiaras. Data dianalisis dengan menggunakan analisis regresi berganda dengan SPSS 21. Hasil dari penelitian ini menyatakan bahwa persepsi tentang norma subyektif dan tingkat indeks prestasi mahasiswa tidak berpengaruh terhadap niat melakukan whistleblowing. Sedangkan variabel sikap terhadap perilaku, persepsi kontrol perilaku, dan jenis kelamin mahasiswa berpengaruh terhadap niat melakukan whistleblowing. Kata kunci: Persepsi, norma subyektif, sikap terhadap perilaku, kontrol perilaku, jenis kelamin, tingkat indeks prestasi, mahasiswa akuntansi, whistleblowing. Perception Accounting Students Againts Intention To Do Whistleblowing (Study at Universities in the city Of Lampung) This study aimed to analyze the perception of accounting students to do whistleblowing intention. This study used questionaire to gather to needed information. Variabel that used in this study were Perceived Subjective Norm, Attitude Toward, Perceived Behavioral Control, Gender, and Level of GPA as an Independent Variable and Intention as Dependent Variable. This study used purposive sampling technique for collected the datas. The size of the sample in this study were 330 sample. Respondent in this study were accounting students Lampung of University, Bandar Lampung of University, Malahayati University, Mitra Lampung Unversity, STIE A2L, and STIE Gentiaras. Data analysis used analysis of multiple regression with SPSS 21. The study states that Perceived Subjective Norm and Level of GPA no significant effect on the intention accounting students do whistleblowing. Meanwhile, Attitude Toward, Perceived Behavioral Control and Gender has a positive impact on the intention accounting students do whistleblowing. Key words : Perception, subjective norm, attitude toward, behavioral control, gender, level of GPA, accounting student, whistleblowing.
Case Study of Major Depressive Disorder

This document pertains to the case study of Major Depressive Disorder. The subject of the disorder was Mr. IR age 33 years, married, an MBA and was serving as manager in a government commercial bank. Mr. IR has one elder brother and an elder stepsister. He was referred to my clinic by an Ex-client. Mr. IR told me about the symptoms he was suffering from. These were; aggressive behavior, sadness, suicidal tendency, lack of interest in routine life matters, disillusionment about his sexual ability, disturbed sleep and at last a unique symptom that he kept sitting, talking and weeping in front of mirror for one or two hours once or twice in a week. He could not recall his actions afterwards which he used to play before mirror. Assessment made after taking semi-structured interviews from Mr.IR and his family. In light of assessment and DSM-IV, it was diagnosed that Mr. IR was suffering from Major Depressive Disorder
Spatio‐temporal distribution of brain activity associated with audio‐visually congruent and incongruent speech and the McGurk Effect

Spatio‐temporal distributions of cortical activity to audio‐visual presentations of meaningless vowel‐consonant‐vowels and the effects of audio‐visual congruence/incongruence, with emphasis on the McGurk effect, were studied. The McGurk effect occurs when a clearly audible syllable with one consonant, is presented simultaneously with a visual presentation of a face articulating a syllable with a different consonant and the resulting percept is a syllable with a consonant other than the auditorily presented one.
ELECTRON-CAPTURE SUPERNOVAE AS SOURCES OF 60Fe

We investigate the nucleosynthesis of the radionuclide 60Fe in electron-capture supernovae (ECSNe). The nucleosynthetic results are based on a self-consistent, two-dimensional simulation of an ECSN as well as models in which the densities are systematically increased by some factors (low-entropy models). 60Fe is found to be appreciably made in neutron-rich ejecta during the nuclear quasi-equilibrium phase with greater amounts being produced in the lower-entropy models. Our results, combining them with the yields of core-collapse supernovae in the literature, suggest that ECSNe account for at least 4%–30% of live 60Fe in the Milky Way. ECSNe co-produce neutron-rich isotopes, 48Ca, 50Ti, 54Cr, some light trans-iron elements, and possibly weak r-process elements including some radionuclides such as 93Zr, 99Tc, and 107Pd, whose association with 60Fe might have been imprinted in primitive meteorites or in the deep ocean crust on the Earth.
Frontal Eye Fields Control Attentional Modulation of Alpha and Gamma Oscillations in Contralateral Occipitoparietal Cortex

Covertly directing visuospatial attention produces a frequency-specific modulation of neuronal oscillations in occipital and parietal cortices: anticipatory alpha (8–12 Hz) power decreases contralateral and increases ipsilateral to attention, whereas stimulus-induced gamma (>40 Hz) power is boosted contralaterally and attenuated ipsilaterally. These modulations must be under top-down control; however, the control mechanisms are not yet fully understood. Here we investigated the causal contribution of the human frontal eye field (FEF) by combining repetitive transcranial magnetic stimulation (TMS) with subsequent magnetoencephalography. Following inhibitory theta burst stimulation to the left FEF, right FEF, or vertex, participants performed a visual discrimination task requiring covert attention to either visual hemifield. Both left and right FEF TMS caused marked attenuation of alpha modulation in the occipitoparietal cortex. Notably, alpha modulation was consistently reduced in the hemisphere contralateral to stimulation, leaving the ipsilateral hemisphere relatively unaffected. Additionally, right FEF TMS enhanced gamma modulation in left visual cortex. Behaviorally, TMS caused a relative slowing of response times to targets contralateral to stimulation during the early task period. Our results suggest that left and right FEF are causally involved in the attentional top-down control of anticipatory alpha power in the contralateral visual system, whereas a right-hemispheric dominance seems to exist for control of stimulus-induced gamma power. These findings contrast the assumption of primarily intrahemispheric connectivity between FEF and parietal cortex, emphasizing the relevance of interhemispheric interactions. The contralaterality of effects may result from a transient functional reorganization of the dorsal attention network after inhibition of either FEF.
Information systems development in a developing country: theoretical analysis of special requirements in Nigeria and Africa

Research approaches on information systems development (ISD) are characterized by diversity, focusing on a wide area of objectives and methods. Nevertheless, the understanding of ISD as a universal phenomenon is less commonly questioned. We can ask if systems development really is the same in Africa as in industrialized countries, because of several differences in contextual factors. We suggest that there are special requirements that should be taken into consideration in systems development methodology in Africa-like sustainability, affordability, socio-economic justification and community participation. We have founded a research programme to develop such a methodology. We present a research framework for studying ISD as a phenomenon in Africa, and particularly in Nigeria. In addition to a literature review and an empirical survey, the research programme consists of descriptive case studies and an action research part experimenting on adjusted methods in the setting of real-life projects. The first results from the initial phase of the study are presented in a hypothetical rather than conclusive way, suggesting the special requirements of ISD in Africa.
Age-Dependent Impairment of Spine Morphology and Synaptic Plasticity in Hippocampal CA1 Neurons of a Presenilin 1 Transgenic Mouse Model of Alzheimer's Disease

Presenilin 1 (PS1) mutations are responsible for a majority of early onset familial Alzheimer's disease (FAD) cases, in part by increasing the production of Aβ peptides. However, emerging evidence suggests other possible effects of PS1 on synaptic dysfunction where PS1 might contribute to the pathology independent of Aβ. We chose to study the L286V mutation, an aggressive FAD mutation which has never been analyzed at the electrophysiological and morphological levels. In addition, we analyzed for the first time the long term effects of wild-type human PS1 overexpression. We investigated the consequences of the overexpression of either wild-type human PS1 (hPS1) or the L286V mutated PS1 variant (mutPS1) on synaptic functions by analyzing synaptic plasticity and associated spine density changes from 3 to 15 months of age. We found that mutPS1 induces a transient increase observed only in 4- to 5-month-old mutPS1 animals in NMDA receptor (NMDA-R)-mediated responses and LTP compared with hPS1 mice and nontransgenic littermates. The increase in synaptic functions is concomitant with an increase in spine density. With increasing age, however, we found that the overexpression of human wild-type PS1 progressively decreased NMDA-R-mediated synaptic transmission and LTP, without neurodegeneration. These results identify for the first time a transient increase in synaptic function associated with L286V mutated PS1 variant in an age-dependent manner. In addition, they support the view that the PS1 overexpression promotes synaptic dysfunction in an Aβ-independent manner and underline the crucial role of PS1 during both normal and pathological aging.