Miracle-dz/UniFAR-FTUs huggingface dataset:
A deep WISE search for very late type objects and the discovery of two halo/thick-disc T dwarfs: WISE 0013+0634 and WISE 0833+0052

A method is defined for identifying late T and Y dwarfs in WISE down to low values of signal-to-noise. This requires a WISE detection only in the W2-band and uses the statistical properties of the WISE multi-frame measurements and profile fit photometry to reject contamination resulting from non-point-like objects, variables and moving sources. To trace our desired parameter space we use a control sample of isolated non-moving non-variable point sources from the SDSS, and identify a sample of 158 WISE W2-only candidates down to a signal-to-noise limit of 8. For signal-to-noise ranges >10 and 8-10 respectively, �45% and �90% of our sample fall outside the selection criteria published by the WISE team (Kirkpatrick et al. 2012), due mainly to the type of constraints placed on the number of individual W2 detections. We present follow-up of eight candidates and identify WISE 0013+0634 and WISE 0833+0052, T8 and T9 dwarfs with high proper motion (�1.3 and �1.8 arcsec yr 1 ). Both objects show a mid-infrared/near-infrared excess of �1-1.5 magnitudes, and are K band suppressed. Distance estimates lead to space motion constraints that suggest halo (or at least thick disk) kinematics. We then assess the reduced proper motion diagram of WISE ultracool dwarfs, which suggests that late T and Y dwarfs may have a higher thick-disk/halo population fraction than earlier objects.
Measuring socio-economic position for epidemiological studies in low- and middle-income countries: a methods of measurement in epidemiology paper

Much has been written about the measurement of socio-economic position (SEP) in high-income countries (HIC). Less has been written for an epidemiology, health systems and public health audience about the measurement of SEP in low- and middle-income countries (LMIC). The social stratification processes in many LMIC—and therefore the appropriate measurement tools—differ considerably from those in HIC. Many measures of SEP have been utilized in epidemiological studies; the aspects of SEP captured by these measures and the pathways through which they may affect health are likely to be slightly different but overlapping. No single measure of SEP will be ideal for all studies and contexts; the strengths and limitations of a given indicator are likely to vary according to the specific research question. Understanding the general properties of different indicators, however, is essential for all those involved in the design or interpretation of epidemiological studies. In this article, we describe the measures of SEP used in LMIC. We concentrate on measures of individual or household-level SEP rather than area-based or ecological measures such as gross domestic product. We describe each indicator in terms of its theoretical basis, interpretation, measurement, strengths and limitations. We also provide brief comparisons between LMIC and HIC for each measure.
Re-envisioning nursing education and practice in Nigeria for the 21st century

The paper explores the current situation and future development of nursing education and practice in Nigeria and their influence on health care. As the role of the nurse continues to expand, Nigerian nurses must be skillful in effectively using evidence-based and clinically relevant information to facilitate the best possible nursing care. Major issues and challenges in this regard are discussed with some recommendations on the way forward.
Renal Histopathology During Experimental Septic Acute Kidney Injury and Recovery*

Objectives:Our understanding of septic acute kidney injury is limited. We therefore assessed renal histopathological changes induced by septic acute kidney injury and their evolution during recovery. Design:Prospective experimental study. Setting:Physiology Research Institute. Subjects:Twenty-two Merino sheep. Intervention:We induced septic acute kidney injury by continuous IV infusion of Escherichia coli. We studied histology, immunohistochemistry, markers of apoptosis, and expression of nitric oxide synthase isoforms and hypoxia-inducible factor-1&agr;. Analysis was performed on kidneys from normal sheep, sheep with septic acute kidney injury, and sheep after recovery from septic acute kidney injury. Measurements and Main Results:In normal, septic, and recovery sheep, respectively, serum creatinine was (median) 82 (interquartile range, 70–85), 289 (171–477), and 70 (51–91) &mgr;mol/L and renal blood flow was 270 ± 42, 653 ± 210, and 250 ± 49 mL/min. There were no histological differences between baseline, acute kidney injury, and recovery sheep. There was no evidence of macrophage or myofibroblast infiltration, no evidence of caspase-3 cleavage to suggest activation of apoptotic pathways, and no increase in neutrophil gelatinase-associated lipocalin to suggest tubular injury. Similarly, quantification of apoptosis revealed no differences between the normal and septic groups (normal: median, 3; interquartile range, 0–5 cells per visual field and septic acute kidney injury: median, 3.5; interquartile range, 0–8 cells per visual field; p = 0.618), but in the recovery group, there was increased apoptosis (median, 14; interquartile range, 4–34 cells per visual field; p = 0.002). Expression of all nitric oxide synthase subtypes increased significantly in the renal cortex during septic acute kidney injury but tended to decrease in the medulla. Medullary hypoxia-inducible factor gene expression decreased from 1.00 (95% CI, 0.74–1.36) to 0.26 (95% CI, 0.09–0.76) in recovery (p = 0.0106). Both inducible nitric oxide synthase and neuronal nitric oxide synthase expressions correlated with renal blood flow. Conclusion:The lack of any tubular injury or increased apoptosis, the increased expression of all cortical nitric oxide synthase isoforms, and the link between inducible nitric oxide synthase and neuronal nitric oxide synthase with renal blood flow suggest in this experimental model that severe sepsis acute kidney injury can develop in the absence of histological or immunohistological changes and may be functional in nature.
Role of the Primary Motor Cortex in the Early Boost in Performance Following Mental Imagery Training

Recently, it has been suggested that the primary motor cortex (M1) plays a critical role in implementing the fast and transient post-training phase of motor skill consolidation, known to yield an early boost in performance. Whether a comparable early boost in performance occurs following motor imagery (MIM) training is still unknown. To address this issue, two groups of subjects learned a finger tapping sequence either by MIM or physical practice (PP). In both groups, performance increased significantly in the post-training phase when compared with the pre-training phase and further increased after a 30 min resting period, indicating that both MIM and PP trainings were equally efficient and induced an early boost in motor performance. This conclusion was corroborated by the results of an additional control group. In a second experiment, we then investigated the causal role of M1 in implementing the early boost process resulting from MIM training. To do so, we inhibited M1 by applying a continuous theta-burst stimulation (cTBS) in healthy volunteers just after they learnt, by MIM, the same finger-tapping task as in Experiment #1. As a control, cTBS was applied over the vertex of subjects who underwent the same experiment. We found that cTBS applied over M1 selectively abolished the early boost process subsequent to MIM training. Altogether, the present study provides evidence that MIM practice induces an early boost in performance and demonstrates that M1 is causally involved in this process. These findings further divulge some degree of behavioral and neuronal similitude between MIM and PP.
Treatment of Displaced Mid-Clavicle Fractures by Closed Titanium Elastic Nail

Introduction: Recently, intramedullary nailing for displaced middle third fractures of clavicle has received wide attention. Though open nailing has been widely described, closed nailing finds less mention. This paper therefore aims to study the outcome of closed titanium elastic nailing for displaced mid-clavicular fractures. Material and Methods: This was a prospective study of 34 patients with displaced middle third clavicle fracture who underwent closed intramedullary nailing with titanium elastic nail at a tertiary care centre. The operative time, length of incision, time for radiological union, pain and functional outcome after union were noted. Results: The mean operative time was 34.33 mins. The mean time of discharge was 2.25 days. The average time of radiological union was 10.23 weeks. All the patients achieved full, painless range of motion of the ipsilateral shoulder. The average Constant-Murley score at 12 months was 94.28 indicating excellent result. Conclusion: Closed titanium elastic nailing offers a safe and minimally invasive method of fixation for fractures of middle-third clavicle with excellent functional outcome.
Assembly and packing of clathrin into coats

We present a model for the packing of clathrin molecules into the characteristic hexagons and pentagons covering coated pits and vesicles. The assembly unit is a symmetrical trimer with three extended legs. Polymerization of these units occurs in seconds under suitable conditions, giving empty polyhedral cages resembling the structures around coated vesicles. Images of small, negatively stained fragments of cages, assembled directly on electron microscope grids, reveal details of the structure, which correlate well with the predicted features of the model. There is one clathrin trimer at each polyhedral vertex, and each leg of the trimer extends along two neighboring polyhedral edges. Quasi-equivalent packing in pentagons and hexagons in polyhedra of different sizes requires a variable joint at the vertex of the molecule and a hinge in each leg. The construction of clathrin coats is remarkable for the extended fibrous contacts that each molecule makes with many others. Such contacts may confer mechanical strength combined with flexibility needed when a vesicle is pinched off from the membrane.
Glucose production by the human placenta in vivo.

The human placenta transports glucose by facilitated diffusion down a concentration gradient from mother to fetus. It has previously been considered incapable of glucose synthesis. However, recent work has demonstrated the presence in placental tissue of glucose-6-phosphatase, which is required for the final step in the synthesis of glucose. Following continuous intravenous infusion into the maternal circulation of the stable isotope, 6,6-(2)H(2)glucose, during elective caesarean section, we have observed isotope dilution in the umbilical vein, without further dilution in the umbilical artery. Using a mathematical model containing maternal, placental and fetal compartments, the data were compatible with the release of glucose by the placenta. We conclude that the human placenta at term can produce glucose.
Cloud-Resolving Model Simulations and a Simple Model of an Idealized Walker Cell

AbstractAn idealized Walker cell with prescribed sea surface temperature (SST) and prescribed radiative cooling is studied using both a two-dimensional cloud-resolving model (CRM) and a simple conceptual model. In the CRM, for the same SST distribution, the width of the warm pool (area of strong precipitation) varies systematically with the magnitude of the radiative cooling, narrowing as radiative cooling is increased. The simple model is constructed to interpret these behaviors. Key aspects of the simple model include a surface wind determined from the boundary layer momentum budget, which in turn sets evaporation assuming a spatially uniform surface relative humidity, prescribed gross moist and dry stratification as a function of column water vapor and precipitation, and a gustiness enhancement on evaporation in areas of precipitation. It is found that the gustiness enhancement, likely due to mesoscale systems, creates a feedback that narrows the warm pool. This process has not been included in previou.
A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts

Asymmetric cell division is a fundamental mechanism used to generate cellular diversity in invertebrates and vertebrates. In Drosophila, asymmetric division of neuroblasts is achieved by the asymmetric segregation of cell fate determinants Prospero and Numb into the basal daughter cell. Asymmetric segregation of cell fate determinants requires an apically localized protein complex that includes Inscuteable, Pins, Bazooka, DmPar-6, DaPKC and Gαi. Pins acts to stabilize the apical complex during neuroblast divisions. Pins interacts and colocalizes with Inscuteable, as well as maintaining its apical localization. We have isolated a mouse homologue of pins (Pins) and characterized its expression profile. Mouse PINS shares high similarity in sequence and structure with Pins and other Pins-like proteins from mammals. Pins is expressed in many mouse tissues but its expression is enriched in the ventricular zone of the developing central nervous systems. PINS localizes asymmetrically to the apical cortex of mitotic neuroblasts when ectopically expressed in Drosophila embryos. Like Pins, its N-terminal tetratricopeptide repeats can directly interact with the asymmetric localization domain of Insc, and its C-terminal GoLoco-containing region can direct localization to the neuroblast cortex. We further show that Pins can fulfill all aspects of pins function in Drosophila neuroblast asymmetric cell divisions. Our results suggest a conservation of function between the fly and mammalian Pins homologues.
A GPU‐Adapted Structure for Unstructured Grids

A key advantage of working with structured grids (e.g., images) is the ability to directly tap into the powerful machinery of linear algebra. This is not much so for unstructured grids where intermediate bookkeeping data structures stand in the way. On modern high performance computing hardware, the conventional wisdom behind these intermediate structures is further challenged by costly memory access, and more importantly by prohibitive memory resources on environments such as graphics hardware. In this paper, we bypass this problem by introducing a sparse matrix representation for unstructured grids which not only reduces the memory storage requirements but also cuts down on the bulk of data movement from global storage to the compute units. In order to take full advantage of the proposed representation, we augment ordinary matrix multiplication by means of action maps, local maps which encode the desired interaction between grid vertices. In this way, geometric computations and topological modifications translate into concise linear algebra operations. In our algorithmic formulation, we capitalize on the nature of sparse matrix‐vector multiplication which allows avoiding explicit transpose computation and storage. Furthermore, we develop an efficient vectorization to the demanding assembly process of standard graph and finite element matrices.
Local therapy and survival in breast cancer.

Some investigators have viewed breast cancer as a local disease that then spreads; others have seen it as a systemic disease from the start. This review argues for another view, since the failure to achieve initial local control allows some tumors to disseminate later, reducing a patient's chance of long-term survival. Recent evidence supports a larger role for aggressive, local therapy for breast cancer.
Hyperspectral Band Selection Using Improved Classification Map

Although it is a powerful feature selection algorithm, the wrapper method is rarely used for hyperspectral band selection. Its accuracy is restricted by the number of labeled training samples and collecting such label information for hyperspectral image is time consuming and expensive. Benefited from the local smoothness of hyperspectral images, a simple yet effective semisupervised wrapper method is proposed, where the edge preserved filtering is exploited to improve the pixel-wised classification map and this in turn can be used to assess the quality of band set. The property of the proposed method lies in using the information of abundant unlabeled samples and valued labeled samples simultaneously. The effectiveness of the proposed method is illustrated with five real hyperspectral data sets. Compared with other wrapper methods, the proposed method shows consistently better performance.
Licos Centre for Transition Economics Licos Discussion Paper the Endogeneity of the Optimum Currency Area Criteria, Intraindustry Trade, and Emu Enlargement the Endogeneity of the Optimum Currency Area Criteria, Intraindustry Trade, and Emu Enlargement

This paper tests the endogeneity hypothesis of OCA criteria (Frankel and Rose, 1998) in a cross-section of OECD countries between 1990 and 1999. It is shown that intraindustry trade actually causes the convergence of business cycles, while there is no direct relation between business cycles and bilateral trade intensity. As far as intraindustry trade is positively correlated with trade, the OCA endogeneity hypothesis is confirmed, although the argumentation follows Krugman (1993). Finally, the endogeneity of OCA criteria implies a comparable degree of business cycle harmonization of CEECs with EU countries as for the current members for the medium term.
Essential contribution of CCL3 to alkali-induced corneal neovascularization by regulating vascular endothelial growth factor production by macrophages

Purpose To evaluate the roles of CCL3 and its specific chemokine receptors, CCR1 and CCR5, in alkali-induced corneal neovascularization (CNV). Methods Chemical denudation of corneal and limbal epithelium was performed on wild-type (WT) BALB/c mice and CCL3-, CCR1-, and CCR5-deficienct (knockout [KO]) counterparts. Two weeks after injury CNV was quantified by immunostaining with anti-CD31. Angiogenic factor expression and leukocyte accumulation in the early phase after injury were quantified by reverse transcription polymerase chain reaction (RT–PCR) and immunohistochemical analysis, respectively. Results Alkali injury augmented the intraocular mRNA expression of CCL3 and its receptors, CCR1 and CCR5, together with a transient infiltration of F4/80 positive macrophages and Gr-1 positive neutrophils. Compared with WT mice, CCL3-KO and CCR5-KO mice but not CCR1-KO mice exhibited reduced CNV two weeks after injury both macroscopically and microscopically as evidenced by CD31 positive areas. Concomitantly, the infiltration of F4/80 positive macrophages but not Gr-1 positive neutrophils was significantly attenuated in CCL3-KO mice compared with WT mice. Intracorneal infiltration of CCR5 expressing cells was significantly impaired in CCL3-KO mice compared with WT mice. Alkali injury induced a massive increase in the intraocular mRNA expression of a potent angiogenic factor, vascular endothelial growth factor (VEGF), in WT mice whereas these increments were severely retarded in CCL3-KO mice. Moreover, CCL3 enhanced VEGF expression by murine peritoneal macrophages at both the mRNA and the protein level. Furthermore, topical CCL3 application restored CNV, which was macroscopically and microscopically reduced in CCL3-KO mice after two weeks to levels similar to those found in WT mice. Conclusions In alkali-induced CNV, CCL3 induced macrophages to infiltrate and produce VEGF by binding to CCR5 but not to CCR1 and eventually promoted angiogenesis.
Contingent imitation increases verbal interaction in children with autism spectrum disorders

Several studies have suggested that contingent adult imitation increase nonverbal communication, such as attention and proximity to adults, in children with autism spectrum disorders. However, few studies have shown the effect of contingent imitation on verbal communication. This study examined whether children with autism were able to promote verbal interaction such as vocal imitation, vocalization, and vocal turn-taking via contingent imitation. We used an alternating treatment design composed of the conditions of contingent imitation and control for six children with autism (aged 33–63 months). For contingent imitation condition, adults imitated children’s vocalization immediately. For control condition, adults did not imitate but gave a vocal response immediately. Results showed that in contingent imitation condition, all children increased the number of vocal imitations and vocal turn-takings compared with control condition. The number of vocalizations increased in both condition for all children. Overall, it is suggested that all children promote verbal interaction via contingent imitation.
The Nutritional Composition of Local Rice Varieties in Guyana

DOI: 10.15580/GJAS.2019. 2.022819041 Rice is one of the most popular cereals worldwide, one of Guyana’s major staple foods produced and consumed. With most of the population dependent on rice as a significant part of their diet, it becomes critical to analyze and monitor its composition. This project was aimed at comparatively analyzing four different local rice varieties cultivated in Guyana and one candidate line for proximate chemical components, vitamins and mineral elements. 2kg of paddy of each variety/line was harvested from pre-basic plots and were cleaned and shelled. Analyses were done by Kaizen Environmental Services Inc. All methods were carried out based on the AOAC (Association of Official Analytical Chemists) method. In this study, the genetic diversity of the rice varieties/lines was reflected by the range of nutritional characteristics. There was no variety that was superior to another in terms of its overall nutritional content; however, there were some that recorded higher levels of one or more nutrients. The average protein was relatively high in both cargo and polished rice (8.50% and 7.78% respectively). Carbohydrates, present in the largest amount in all 5 varieties, ranged from 70.94% to 73.57% for cargo/brown rice and 73.85% to 77.11% for polished rice. It was also observed that the degree of milling also influenced the nutritional composition of the grain. The unpolished /brown/cargo rice contained higher amounts of all nutrients except carbohydrates when compared to the polished/white rice. The effect of poor nutritional value of rice can result in short life expectation, the prevalence of diseases, poor physical development and reduced working capacity; and so it is important that rice produced meets the requirements for its population. Submitted: 28/02/2019 Accepted: 05/03/2019 Published: 09/04/2019