Miracle-dz/UniFAR-FTUs huggingface dataset:
Sexuality and the asylum process : the perspectives of lesbians seeking asylum in the UK

The 1951 Refugee Convention aims to provide international legal protection to all asylum seekers. Individuals making asylum claims based on persecution which relates to their sexual orientation however are not explicitly represented in Article 1A (2) of the Convention. As a consequence, cases based on sexual orientation are usually argued under the ‘membership of a particular social group’ category, a classification which has long remained the most contested of the Refugee Convention grounds for granting asylum. This thesis focuses on the experiences of lesbian women as they navigate the UK asylum process. The research explores how sexuality is constructed and performed as women seek asylum as well as how this impacts upon their social and sexual identity. A theoretical framework for the study is principally (though not exclusively) drawn from the works of Judith Butler (1990, 2004, 2006) and Michel Foucault (1978, 1979), as well as Ken Plummer’s (1995) ‘telling sexual stories’. The research draws upon in-depth, repeat interviews with eleven lesbian asylum seekers and refugees in the UK. These women all reported to have experienced physical and sexual violence in their home countries as a consequence of their homosexuality and all had sought international protection in the UK on the basis of their sexuality. The analysis presented in this thesis reveals that the experience of going through the UK asylum process was, for the women in this study, an emotionally challenging and confusing experience. As a consequence of women’s traumatic experiences in their home countries, they were often over familiar with secrecy which added to the difficulties of self-identifying as a lesbian in the UK. The legal requirement to evidence and ‘prove’ one’s sexual orientation was considered problematic and frequently left women feeling compelled to ‘perform’ their sexual identity in order to be believed as a credible lesbian. In addition the analysis presented demonstrates that the requirement to share intimate narratives on demand and in an open and public way had a range of significant implications on women themselves. This included how women felt that their sexuality was persistently judged and the devastating impact of not being believed. This thesis also shows how navigating complex legal procedures impacts upon women’s social and sexual identity. The study demonstrates that living in limbo, without permanency and stability exacerbated women’s experiences of social isolation and rejection and left them occupying a distinct social space, excluded from British, asylum seeking and migrant groups. Despite these struggles however, the data presented in the thesis also reveals women’s ability to recognise, fight and campaign for their legal citizenship and to enjoy the freedom to express their sexual identity and sexual self-esteem. The desire to create a safe space, to understand their sexuality and to re-construct a sense of belonging was paramount as women fought for their sexual entitlements.
A Network of Local and Redundant Gene Regulation Governs Arabidopsis Seed Maturation

In Arabidopsis thaliana, four major regulators (ABSCISIC ACID INSENSITIVE3 [ABI3], FUSCA3 [FUS3], LEAFY COTYLEDON1 [LEC1], and LEC2) control most aspects of seed maturation, such as accumulation of storage compounds, cotyledon identity, acquisition of desiccation tolerance, and dormancy. The molecular basis for complex genetic interactions among these regulators is poorly understood. By analyzing ABI3 and FUS3 expression in various single, double, and triple maturation mutants, we have identified multiple regulatory links among all four genes. We found that one of the major roles of LEC2 was to upregulate FUS3 and ABI3. The lec2 mutation is responsible for a dramatic decrease in ABI3 and FUS3 expression, and most lec2 phenotypes can be rescued by ABI3 or FUS3 constitutive expression. In addition, ABI3 and FUS3 positively regulate themselves and each other, thereby forming feedback loops essential for their sustained and uniform expression in the embryo. Finally, LEC1 also positively regulates ABI3 and FUS3 in the cotyledons. Most of the genetic controls discovered were found to be local and redundant, explaining why they had previously been overlooked. This works establishes a genetic framework for seed maturation, organizing the key regulators of this process into a hierarchical network. In addition, it offers a molecular explanation for the puzzling variable features of lec2 mutant embryos.
A Randomized Phase IIb Trial of Pulmicort Turbuhaler (Budesonide) in People with Dysplasia of the Bronchial Epithelium

Purpose: Preclinical studies suggest that inhaled budesonide may be an effective chemopreventive agent for lung cancer. We conducted a phase IIb study to determine the effects of inhaled budesonide in smokers with bronchial dysplasia. Experimental Design: A total of 112 smokers with more than or equal to one site of bronchial dysplasia > 1.2 mm in size identified by autofluorescence bronchoscopy-directed biopsy was randomly assigned to receive placebo or budesonide (Pulmicort Turbuhaler) 800 μg twice daily inhalation for 6 months. The primary end point was change in the histopathologic grade on repeat biopsy of the same sites at the end of 6 months. Results: There were no significant differences in the regression or progression rates of bronchial dysplasia between the two groups. There was a statistically significant but modest decrease in p53 and BclII expression in the bronchial biopsies after 6 months of Pulmicort Turbuhaler versus placebo (P = 0.01 and P = 0.001, respectively). There was a small but statistically significant decrease in the proportion of computed tomography-detected lung nodules after Pulmicort Turbuhaler compared with placebo (P = 0.024). Conclusions: Our results suggest that in smokers, inhaled budesonide in the dose of 1600 μg daily for 6 months had no effect in regression of bronchial dysplastic lesions or prevention of new lesions. Budesonide treatment resulted in a modest decrease in p53 and BclII protein expression in bronchial biopsies and a slightly higher rate of resolution of computed tomography-detected lung nodules. Whether budesonide truly has an effect in preneoplastic lesions in the peripheral airways and alveoli requires additional investigation.
Cognitive capability versus system complexity in electronic maintenance

Diagnostic behavior is strongly influenced by the interaction between the diagnostician and the failed equipment. Previous research resulted in a model of diagnostic behavior that predicts repair time distributions and expected values. In this work the relationship between expected value of repair time, equipment complexity, and human cognitive limitations is developed. Specifically, it is shown that if equipment complexity, as measured by degree of interconnectedness of components, exceeds normal human cognitive limitations, then some proportion of equipment failures will be nondiagnosable.
Unbalanced Metalloproteinase-9 and Tissue Inhibitors of Metalloproteinases Ratios Predict Hemorrhagic Transformation of Lesion in Ischemic Stroke Patients Treated with Thrombolysis: Results from the MAGIC Study

Background Experimentally, metalloproteinases (MMPs) play a detrimental role related to the severity of ischemic brain lesions. Both MMPs activity and function in tissues reflect the balance between MMPs and tissue inhibitors of metalloproteinases (TIMPs). We aimed to evaluate the role of MMPs/TIMPs balance in the setting of rtPA-treated stroke patients. Methods Blood was taken before and 24-h after rtPA from 327 patients (mean age 68 years, median NIHSS 11) with acute ischemic stroke. Delta median values of each MMP/TIMP ratio [(post rtPA MMP/TIMP-baseline MMP/TIMP)/(baseline MMP/TIMP)] were analyzed related to symptomatic intracranial hemorrhage (sICH) according to NINDS criteria, relevant hemorrhagic transformation (HT) defined as confluent petechiae within the infarcted area or any parenchymal hemorrhage, stroke subtypes (according to Oxfordshire Community Stroke Project) and 3-month death. The net effect of each MMP/TIMP ratio was estimated by a logistic regression model including major clinical determinants of outcomes Results Adjusting for major clinical determinants, only increase in MMP9/TIMP1 and MMP9/TIMP2 ratios remained significantly associated with sICH (odds ratio [95% confidence interval], 1.67 [1.17–2.38], p = 0.005; 1.74 [1.21–2.49], p = 0.003, respectively). Only relative increase in MMP9/TIMP1 ratio proved significantly associated with relevant HT (odds ratio [95% confidence interval], 1.74 [1.17–2.57], p = 0.006) with a trend toward significance for MMP9/TIMP2 ratio (p = 0.007). Discussion Our data add substantial clinical evidence about the role of MMPs/TIMPs balance in rtPA-treated stroke patients. These results may serve to generate hypotheses on MMPs inhibitors to be administered together with rtPA in order to counteract its deleterious effect.
Reactivation of Expression from Quiescent Herpes Simplex Virus Type 1 Genomes in the Absence of Immediate-Early Protein ICP0

ABSTRACT Model systems have previously been developed in which herpes simplex virus (HSV) is retained in human fibroblasts in a nonreplicating state known as quiescence. The HSV type 1 (HSV-1) immediate-early (IE) protein ICP0, an important activator of gene expression, reactivates the quiescent genome and promotes the resumption of virus replication. Previous studies reported that infection with ICP0-null HSV-1 mutants fails to reactivate quiescent HSV, even when the mutant itself undergoes productive replication, leading to the hypothesis that quiescent genomes exist in a silent configuration in which they are shielded from trans-acting factors. I reinvestigated these findings, using HSV-1 mutants with lesions in the transcription activators VP16, ICP0, and ICP4 to establish quiescent infection at high efficiency. Superinfection with ICP0-null HSV-1 mutants at a low multiplicity of infection (MOI), so that individual plaques were formed, reactivated expression from the quiescent genome, demonstrating that the requirement for ICP0 is not absolute. The previously reported failure to observe reactivation by ICP0-null mutants was shown to be a consequence of either a low initial MOI or a high superinfecting MOI. Competition between viral genomes at the level of gene expression and virus replication, especially when ICP0 was absent, was demonstrated during reactivation and also during normal infection of human fibroblasts. The results show that the multiplicity-dependent phenotype of ICP0-null mutants limits the efficiency of reactivation at low MOIs and that competition between genomes occurs at high MOIs. The conclusion that quiescent HSV genomes are extensively silenced and intrinsically insensitive to trans-acting factors must be reevaluated.
Misdiagnosis and Missed Diagnoses in Foster and Adopted Children With Prenatal Alcohol Exposure

OBJECTIVE: The purpose of this article is to assess the rate of misdiagnosis and missed diagnoses of fetal alcohol spectrum disorders (FASD) among a population of foster and adopted youth referred to a children’s mental health center. METHODS: Data were collected from a sample of 547 children who underwent a comprehensive multidisciplinary diagnostic evaluation. Utilizing current diagnostic criteria, children were diagnosed, as appropriate, with fetal alcohol syndrome, partial fetal alcohol syndrome, alcohol-related neurodevelopmental disorder, or alcohol-related birth defects. Changes in rates of alcohol exposure-related diagnoses and cooccurring mental health disorders pre- and postassessment were analyzed by using McNemar’s test for dependent proportions. RESULTS: Among 156 children and adolescents who met criteria for a diagnosis within the fetal alcohol spectrum, 125 had never been diagnosed as affected by prenatal alcohol exposure, a missed diagnosis rate of 80.1%. Of the 31 who had been recognized before referral as affected by prenatal alcohol exposure, 10 children’s FASD diagnoses were changed within the spectrum, representing a misdiagnosis rate of 6.4%. The remaining 21 (13.5%) children’s diagnoses stayed the same. There also were significant changes in the rate of mental health diagnosis, and learning disorders, communication disorders, and intellectual disability, objective signs of neurocognitive damage, were not recognized in a significant number of children with FASD. CONCLUSIONS: Within this clinical sample, 86.5% of youth with FASD had never been previously diagnosed or had been misdiagnosed. These high rates of missed diagnoses and misdiagnosis have significant implications for intervention and therapeutic services.
Community Perception of Single Parenting in Zaria, Northern Nigeria

Child nurturing is usually a shared responsibility between both parents, until in recent times that lone parenting is becoming more widespread. Viewed in diverse ways by many authors, it is simply raising a child by one parent alone, whether the other parent is alive or not. This is seen as normal by some, and thus offer social support; or as absurd, unacceptable, shameful and thus stigmatized both the lone parents and their children. How does the Zaria community perceive single parenthood? A descriptive cross-sectional survey in two urban Local Government Areas in Zaria metropolis was conducted, using a researcher-constructed questionnaire. Data obtained from 270 respondents were analysed descriptively using SPSS 21.0. Results indicated that single parenting is a common reality in the study setting: the main causes of which include divorce, children born out of wedlock and some parents choosing to have children as single parents. It is believed that factors such as the quest for economic independence by some women as well as social approval/choices are contributory to its increasing prevalence. There are perceived positive and negative effects associated with single parenting. Many respondents advocated for some assistance such as provision of basic needs and free education for single-parent families and children, depending on the cause/route to single parenting. It is concluded that single parenting is an increasing social issue, with limited acceptance in the study area. Strengthening the family institution to reduce contention factors that break intact families should form part of social engineering to forestall negative effects of single parenting.
To Compare the Effectiveness of Short-term Three Dose Perioperative Antibiotic Coverage during Decisive Period with Conventional Prolonged Postoperative Antibiotic Usage in Clean Elective Surgical Cases: An Indian Perspective

Background: Surgical site infections are the most common postoperative complications and frequently cause morbidity and mortality. Different antibiotic regimens were evaluated as prophylaxis in wound infection following elective surgical procedures. Prophylactic antibiotics should be given to cover the “decisive period” which is a period after incision to mobilization of host defenses thus preventing an infection from developing. Objectives: The aim is to study the effectiveness of short-term antibiotic coverage during decisive period in the prevention of postoperative wound sepsis in clean surgical cases. Materials and Methods: The prospective randomized comparative study included 50 patients divided into two groups of 25 each. Group A (short-term ceftriaxone prophylaxis) patients received three doses of 1 g intravenous ceftriaxone. First dose 12 h, 2nd dose 1 h before operation and the 3rd dose was given 10 h after the operation. The Group B (conventional postoperative ceftriaxone prophylaxis) patients received postoperatively 1 g B. D intravenous ceftriaxone for 5 days. We compared the incidence of surgical site infection in two groups. Study Period: November 2014 to September 2016. A predesigned and pretested proforma was used to collect the data. Surgical sites were examined for 30 days. Robertson grading was used to assess the severity of infection. Results: Surgical site infection rate was 4% in Group A and 24% in Group B. The severity of infection was less in short-term prophylaxis group. Anemia, nutritional status, and use of drain were other factors associated with postoperative wound infections. Conclusion: Short course perioperative (three doses) ceftriaxone prophylaxis is sufficient in preventing wound infection. Prophylactic antibiotic should be given to cover the decisive period to prevent an infection from developing. The judicious use of antibiotics can reduce the cost, unnecessary prolonged exposure, side effects, and the emergence of resistant micro-organisms.
VPFS: building a virtual private file system with a small trusted computing base

In this paper we present the lessons we learned when developing VPFS, a virtual private file system that is based on both a small amount of trusted storage and an untrusted legacy file system residing on the same machine. VPFS' purpose is to provide secure and reliable storage to highly sensitive applications running on top of a microkernel, which may concurrently execute untrusted software. The confidentiality and integrity guarantees of VPFS do not only apply to file contents, but also to all meta data including integrity of the directory structure. We explored design alternatives that allow us to securely reuse untrusted infrastructure and thereby minimize the complexity that a file-system implementation adds to the trusted computing base. VPFS is split into two isolated components. A small trusted component implements all security-critical functionality, whereas the untrusted part reuses an existing file-system implementation provided by a virtualized legacy operating system that can be untrusted. In our VPFS prototype, alternative configurations of the trusted component comprise only between 4,000 and 4,600 lines of code, which is at least an order of magnitude smaller than existing commodity file-system stacks.
Does Integrative Restoration (iRest) Meditation Decrease Perceived Stress Levels and Negative Moods in School Counselors

Counseling Association by Dr. Garry R. Walz and Dr. Jeanne C. Bleuer of Counseling Outfitters, LLC. Its purpose is to provide a means of capturing the ideas, information and experiences generated by the annual ACA Conference and selected ACA Division Conferences. Papers on a program or practice that has been validated through research or experience may also be submitted. This digital collection of peer-reviewed articles is authored by counselors, for counselors. VISTAS Online contains the full text of over 500 proprietary counseling articles published from 2004 to present.
Validation Studies of a New Computer Attitude Scale

AbstractTo explore the usefulness of a new instrument, the Computer Attitude Scale, its subsidies (Computer Anxiety, Computer Confidence, Computer Liking) were subjected to two validation studies. The first study examined the reliability and factorial validity of the subscales. The second study analyzed the results of preprogram-postprogram administration of the subscales. The results of the studies suggest that the Computer Attitude Scale is a convenient. reliable and valid measure of computer attitudes, and that it can be confidently and effectively utilized in research and program evaluation contexts.
State of the Art in the Treatment of Systemic Vasculitides

Anti-neutrophil cytoplasm antibodies (ANCA) are associated with small vessel vasculitides (AASV) affecting the lungs and kidneys. Structured clinical assessment using the Birmingham Vasculitis Activity Score and Vasculitis Damage Index should form the basis of a treatment plan and be used to document progress, including relapse. Severe disease with organ or life threatening manifestations needs cyclophosphamide or rituximab, plus high dose glucocorticoids, followed by lower dose steroid plus azathioprine, or methotrexate. Additional plasmapheresis is effective for very severe disease, reducing dialysis dependence from 60 to 40% in the first year, but with no effect on mortality or long-term renal function, probably due to established renal damage. In milder forms of ANCA-associated vasculitis, methotrexate, leflunomide, or mycophenolate mofetil are effective. Mortality depends on initial severity: 25% in patients with renal failure or severe lung hemorrhage; 6% for generalized non-life threatening AASV but rising to 30–40% at 5 years. Mortality from GPA is four times higher than the background population. Early deaths are due to active vasculitis and infection. Subsequent deaths are more often due to cardiovascular events, infection, and cancer. We need to improve the long-term outcome, by controlling disease activity but also preventing damage and drug toxicity. By contrast, in large vessel vasculitis where mortality is much less but morbidity potentially greater, such as giant cell arteritis (GCA) and Takayasu arteritis, therapeutic options are limited. High dose glucocorticoid results in significant toxicity in over 80%. Advances in understanding the biology of the vasculitides are improving therapies. Novel, mechanism based therapies such as rituximab in AASV, mepolizumab in eosinophilic granulomatosis with polyangiitis, and tocilizumab in GCA, but the lack of reliable biomarkers remains a challenge to progress in these chronic relapsing diseases.
False memory for trauma-related Deese–Roediger–McDermott lists in adolescents and adults with histories of child sexual abuse

Abstract The purpose of the present research was to examine Deese–Roediger–McDermott false memory for trauma-related and nontrauma-related lists in adolescents and adults with and without documented histories of child sexual abuse (CSA). Individual differences in psychopathology and adult attachment were also explored. Participants were administered free recall and recognition tests after hearing CSA, negative, neutral, and positive Deese–Roediger–McDermott lists. In free recall, CSA and negative lists produced the most false memory. In sharp contrast, for recognition, CSA lists enjoyed the highest d′ scores. CSA-group adolescents who evinced greater posttraumatic stress disorder (PTSD) symptoms had higher rates of false memory compared to (a) non-CSA group adolescents with higher PTSD symptom scores (free recall), and (b) CSA-group adolescents with lower PTSD symptom scores (recognition). Regression analyses revealed that individuals with higher PTSD scores and greater fearful-avoidant attachment tendencies showed less proficient memory monitoring for CSA lists. Implications for trauma and memory development and for translational research are discussed.
Predicting the effects of temperature on food web connectance

Few models concern how environmental variables such as temperature affect community structure. Here, we develop a model of how temperature affects food web connectance, a powerful driver of population dynamics and community structure. We use the Arrhenius equation to add temperature dependence of foraging traits to an existing model of food web structure. The model predicts potentially large temperature effects on connectance. Temperature-sensitive food webs exhibit slopes of up to 0.01 units of connectance per 1°C change in temperature. This corresponds to changes in diet breadth of one resource item per 2°C (assuming a food web containing 50 species). Less sensitive food webs exhibit slopes down to 0.0005, which corresponds to about one resource item per 40°C. Relative sizes of the activation energies of attack rate and handling time determine whether warming increases or decreases connectance. Differences in temperature sensitivity are explained by differences between empirical food webs in the body size distributions of organisms. We conclude that models of temperature effects on community structure and dynamics urgently require considerable development, and also more and better empirical data to parameterize and test them.