Miracle-dz/UniFAR-FTUs huggingface dataset:
Communication skills attitude scale: a translation and validation study in asample of registered nurses in Poland

Objectives To translate and validate the Communication Skills Attitude Scale in the Polish language (CSAS-P) and its adaptation for use among registered nurses. Design A cross-sectional descriptive design was used in order to translate and validate the CSAS-P. The following psychometric properties of CSAS-P were evaluated: content validity (content validity index), theoretical relevance (exploratory and confirmative factor analysis), one-dimensionality of subscales (principal component analysis), internal consistency (Cronbach’s α), test–retest reliability and discriminant validity. Setting Participants were identified and recruited from the Centre for Postgraduate Education for Nurses and Midwives in Warsaw, Poland. Participants The validation group comprised 2014 registered nurses who were undertaking a spring specialisation exam in 2017. Results The overall content validity index was >0.80, which was interpreted as indicating validity. The factor structure of CSAS-P differed from the original version, and removing three items from the scale better fit the data. The positive attitude subscale (11 items) and negative attitude subscale (12 items) were characterised by one-dimensionality and high internal consistency (Cronbach’s α=0.901 and 0.802, respectively). Test–retest analysis confirmed the stability of the measurement for both subscales and particular items. Nurses with prior participation in communication courses scored significantly higher than those without such education (p<0.05), confirming the discriminant validity of CSAS-P. Conclusions The psychometric properties of CSAS-P were comparable to the English language original. Further validation of CSAS-P in other groups of healthcare professionals may increase its applicability. CSAS-P can be used to evaluate attitudes towards learning communication skills among registered nurses.
Evolution and Nucleosynthesis of Primordial Low-Mass Stars

We discuss in detail the evolutionary properties of low-mass stars (M ≤ 1 M☉) having metallicity lower than Z = 10-6 from the pre-main sequence up to (almost) the end of the early asymptotic giant branch phase. We also discuss the possibility that the large [C/Fe], [N/Fe] observed on the surface of the most iron-poor star currently known, HE 0107-5240, could be attributed to the autopollution induced by the penetration of the He convective shell into the H-rich mantle during the He core flash of a low-mass, very low metallicity star. On the basis of a quite detailed analysis, we conclude that the autopollution scenario cannot be responsible for the observed chemical composition of HE 0107-5240.
Performance Analysis of 32 × 10 Gb/s DWDM Optical System using YDFA for Different Channels Spacing

In this paper, 32 × 10Gb/s dense wavelength division multiplexing (DWDM) optical system using ytterbium doped fiber amplifier (YDFA) having 100GHz, 75GHz, 50GHz and 25GHz channel spacing with starting frequency 193.414THz has been investigated. The performance of the end channel (first) has been considered being the worst case scenario to analyze the system. The DWDM system is evaluated by varying the length for the optical fiber from 40160km. It has been found that as the channel spacing decreases the performance drastically degrades owing to four wave mixing (FWM) effect. The best results have been reported for the system at the 100GHz channel spacing where the maximum Q factor (23.35dB) and output power (-1.156dBm) is achieved at 40km fiber length. Further, it is found that the maximum repeater-less transmission distance of the system with 100GHz and 25GHz channel spacing is 160km and 60km corresponding to BER < 10.
Extending the Sheba Propagation Model to Reduce parameter-Related uncertainties

Heliophysics is the branch of physics that investigates the interactions and cor-relation of diﬀerent events across the Solar System. The mathematical modelsthat describe and predict how physical events move across the solar system (ie.Propagation Models) are of great relevance. These models depend on parame-ters that users must set, hence the ability to correctly set the values is key toreliable simulations. Traditionally, parameter values can be inferred from dataeither at the source (the Sun) or arrival point (the target) or can be extrapo-lated from common knowledge of the event under investigation. Another way ofsetting parameters for Propagation Models is proposed here: instead of guess-ing a priori parameters from scientiﬁc data or common knowledge, the model isexecuted as a parameter-sweep job and selects a posteriori the parameters thatyield results most compatible with the event data. In either case (a priori anda posteriori), the correct use of Propagation Models requires information toeither select the parameters, validate the results, or both. In order to do so, itis necessary to access sources of information. For this task, the HELIO projectproves very eﬀective as it oﬀers the most comprehensive integrated informationsystem in this domain and provides access and coordination to services to mineand analyze data. HELIO also provides a Propagation Model called SHEBA,the extension of which is currently being developed within the SCI-BUS project(a coordinated eﬀort for the development of a framework capable of oﬀering toscience gateways seamless access to major computing and data infrastructures).
More than skin deep: Judgments of individuals with facial disfigurement.

People’s physical appearance can have a profound impact on their social interactions. Faces are often the first thing we notice about people and the basis on which we form our first impressions of them. People with facial disfigurement are discriminated against throughout their lives. Currently, we do not know why this discrimination occurs. In order to develop viable interventions, we must first understand the nature of people’s reactions to disfigurement. In this work, we tested the hypothesis that a “disfigured is bad” stereotype exists, wherein people attribute negative characteristics to individuals with facial disfigurement. People made judgments of individuals before and after they received corrective treatment for their disfigurement. Observers reported lower emotional valence (i.e., more negative emotion), higher arousal, and lower dominance when viewing pretreatment (vs. posttreatment) photographs. Moreover, pictured pretreatment individuals were viewed significantly more negatively in terms of personality (e.g., emotional stability, conscientiousness), internal attributes (e.g., happiness, intelligence), and social attributes (e.g., trustworthiness, popularity). These subjective judgments further reduced to people with disfigurement being regarded as less sociable and happy, less dominant, less emotionally stable, and more as objects of curiosity compared with those with corrected facial disfigurement. Our findings suggest that negative stereotype of people with facial disfigurement may drive discrimination in social, academic, and professional contexts. Knowing what inferences people draw on the basis of disfigurement will make it possible to design interventions to improve the way people with disfigurement are viewed and ultimately treated by others.
Quality of Life after Endoscopic Submucosal Dissection for Early Gastric Cancer: A Prospective Multicenter Cohort Study

Background/Aims Endoscopic submucosal dissection (ESD) has been an established treatment for indicated early gastric cancer (EGC) without deterioration of quality of life (QOL) compared with surgical resection. The aim of this study was to evaluate long-term QOL in patients undergoing ESD for EGC. Methods Patients scheduled to undergo curative ESD for EGC were prospectively enrolled from 12 institutions between May 2010 and December 2011. Assessments of QOL with Korean versions of the European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire-core (QLQ-C30) and a gastric cancer-specific questionnaire (STO22) were performed at baseline and at 7 days, 3 months, and 6 months after ESD. Results A total of 666 subjects were assessed for QLQ-C30 and QLQ-STO22. The mean QLQ-C30 score was 69.5 at baseline, 68.8 at 7 days, 73.1 at 3 months, and 73.2 at 6 months. The global health status on the EORTC QLQ-C30 was significantly improved after 3 and 6 months (p=0.0003 and p<0.0001, respectively). The QLQ-C30 and STO22 scores were not significantly different, or they only slightly deteriorated between before and immediately after ESD, but they were significantly improved after 3 and 6 months (p<0.05). Conclusions QOL did not deteriorate immediately after ESD, and it improved more significantly at up to 6 months in patients who underwent curative ESD for EGC without significant complications.
Improvement of Care in Patients With Colorectal Cancer: Influence of the Introduction of Standardized Structured Reporting for Pathology.

PURPOSE The use of standardized structured reporting (SSR) can improve communication between cancer specialists, which might improve clinical care; however, there are no reliable data on whether the introduction of SSR is associated with improvements in clinical outcome. PATIENTS AND METHODS We performed a retrospective cohort study in the Netherlands, including all patients with colorectal cancer (CRC) from 2009 to 2014. As a reference, cohorts of 2007 and 2008 were included. Data from the Netherlands Cancer Registry were used and combined with data from the Dutch Pathology Registry (PALGA) and the Dutch ColoRectal Audit. We tested the preformulated hypothesis that use of SSR improves the care of patients with CRC by improving the completeness of the pathology reports, the quality of the pathology evaluation, and patient outcomes with respect to treatment and survival. RESULTS We included 72,859 patients with CRC (23.8% reference, 32.9% SSR, and 43.3% narrative reports). Use of SSR increased over time, which resulted in more complete pathology reports (95.8% v 89.8%; P < .001). Risk assessment in stage II colon cancer was more adequate and resulted in an increased delivery of adjuvant therapy in patients with SSR (19.6% v 15.1%; P = .001). Risk of death for patients in the SSR group was significantly lowered (corrected hazard ratio, 0.94; 95% CI 0.90 to 0.97). CONCLUSION We demonstrate that use of SSR improved patient care in those with CRC by providing more complete reports of higher quality, which had significant effects on the delivery of adjuvant therapy and patient outcomes.
Improved flowing behaviour and gas exchange of stored red blood cells by a compound porous structure

Abstract Storage lesions in red blood cells (RBCs) hinder efficient circulation and tissue oxygenation. The absence of flow mechanics and gas exchange may contribute to this problem. To test if in vitro compensation of flow mechanics and gas exchange helps RBC recovery, three-dimensional polydimethylsiloxane (PDMS) porous structures were fabricated with a sugar mould, simulating lung alveoli. RBC suspensions were passed through the porous structure cyclically, simulating in vivo blood circulation. Acid-base indices, partial gas pressures, ions, glucose and RBC indices were analyzed. An atomic force microscope was used to investigate local mechanical properties of intact RBCs. RBCs suspensions that passed through the porous structures had a higher pH and oxygen partial pressure, and a lower potassium concentration and carbon dioxide partial pressure. Meantime they had better biochemical properties relative to static samples, namely, they exhibited a more homogenous distribution of Young’s Modulus. RBCs that passed through a PDMS porous structure were healthier than static ones, giving hints to prevent RBC storage lesions.
Hot and Cool Executive Function and its Relation to Theory of Mind in Children with and without Autism Spectrum Disorder

ABSTRACT Previous research has clearly demonstrated that autism spectrum disorder (ASD) involves deficits in multiple neuropsychological functions, such as executive function (EF) and theory of mind (ToM). A conceptual distinction is commonly made between cool and hot EF. In ASD, continued attention has been paid to the cool areas of executive dysfunction. Cool EF has been strongly related to ToM, but research has not taken into account the association between hot EF and ToM in ASD. The present study investigated the associations between hot and cool EF and ToM in 56 school-aged children with ASD and 69 controls on tasks tapping cool EF (i.e., working memory, inhibition, planning), hot EF (i.e., affective decision making, delay discounting), and ToM (i.e., mental state/emotion recognition and false belief). Significant group differences in each EF measure support an executive dysfunction in both domains in ASD. Strong associations between delay discounting and ToM mental state/emotion recognition were found, suggesting that hot EF makes a unique contribution to ToM above and beyond cool EF in typical development and ASD. This study improves understanding of the profile of higher-order cognitive deficits in children with ASD, which may inform diagnosis and intervention.
Anti‐PrP antibodies block PrPSc replication in prion‐infected cell cultures by accelerating PrPC degradation

The use of anti‐PrP antibodies represents one of the most promising strategies for the treatment of prion diseases. In the present study, we screened various anti‐PrP antibodies with the aim of identifying those that would block PrPSc replication in prion‐infected cell culture. Two antibodies, SAF34 recognizing the flexible octarepeats region on HuPrP protein, and SAF61 directed against PrP amino acid residues (144–152), not only inhibited PrPSc formation in prion‐infected neuroblastoma cells but also decreased the PrPC levels in non‐infected N2a cells. In addition, treatment with both SAF34 and SAF61 antibodies decreased PrPC and PrPSc levels in the cells synergistically. In the presence of both antibodies, our results showed that the mode of action which leads to the disappearance of PrPSc in cells is directly coupled to PrPC degradation by reducing the half‐life of the PrPC protein.
COMMUNICATION PATTERNS AMONG KIAIS OF NAHDLATUL ULAMA IN THE MADURESE ETHNIC GROUP

Research on communication patterns with an ethnographic approach has been conducted by many linguists, but apparently there has hardly been any research on communication patterns within an NU society with its strong paternalistic cultural background. In fact, the uniqueness of this culture also has had a major influence on NU members’ communication patterns in their daily interaction. This study aims to describe the communication patterns among kiais (venerated teachers of Islam) of Nahdlatul Ulama in the Madurese ethnic group (NUME) and account for the factors affecting those patterns of communication. A qualitative method with an ethnographic approach was applied to achieve this research’s objectives. The data were collected through participatory and non-participatory observations, interviews, note-taking, and recording. The recorded data were transcribed and analyzed descriptively using the components of speech analysis, conversational analysis, discourse analysis with pragmatic concepts, and explanation. This study found that giving an honor to the teacher in the NU tradition is an obligation and a tradition that is still maintained. This phenomenon is reflected in the patterns of communication among kiais that have teacher-student ties (KT-KS). The patterns of communication among kiais bearing teacher-students ties (KT-KS) are influenced by situational factors, i.e. formal and informal situations. In an informal situation the KT-KS patterns of communication are influenced by age differences. The age differences that affect the gaps of KT-KS patterns of communication both in formal and informal situations only find expression in the use of speech levels, while in terms of patterns of language selection, tones of voice, body language, and turn-taking, the differences were not found.
Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program

Significance Skeletal muscle harbors a robust, yet quiescent stem cell population. These stem cells are activated upon myofiber injury to repair damaged myotome. This regenerative myogenesis is guided by external signaling cues that allow stem cells to acquire various stem cell fates. Here, we describe a growth factor and nutrient-stimulated pathway, whereby mammalian target of rapamycin (mTOR) activates Per–Arnt–Sim domain kinase (PASK) protein kinase in muscle stem cells. This mTOR-dependent activation of PASK is required for the transcriptional induction of the myogenin gene and subsequent terminal differentiation program. Finally, our results suggest that mTOR-PASK and mTOR-S6 Kinase signaling are required for distinct stages of myogenesis program, and link nutrient environment to early stages of the myogenesis program. During skeletal muscle regeneration, muscle stem cells (MuSCs) respond to multiple signaling inputs that converge onto mammalian target of rapamycin complex 1 (mTORC1) signaling pathways. mTOR function is essential for establishment of the differentiation-committed progenitors (early stage of differentiation, marked by the induction of myogenin expression), myotube fusion, and, ultimately, hypertrophy (later stage of differentiation). While a major mTORC1 substrate, p70S6K, is required for myotube fusion and hypertrophy, an mTORC1 effector for the induction of myogenin expression remains unclear. Here, we identified Per–Arnt–Sim domain kinase (PASK) as a downstream phosphorylation target of mTORC1 in MuSCs during differentiation. We have recently shown that the PASK phosphorylates Wdr5 to stimulate MuSC differentiation by epigenetically activating the myogenin promoter. We show that phosphorylation of PASK by mTORC1 is required for the activation of myogenin transcription, exit from self-renewal, and induction of the myogenesis program. Our studies reveal that mTORC1-PASK signaling is required for the rise of myogenin-positive committed myoblasts (early stage of myogenesis), whereas mTORC1-S6K signaling is required for myoblast fusion (later stage of myogenesis). Thus, our discoveries allow molecular dissection of mTOR functions during different stages of the myogenesis program driven by two different substrates.
A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

Dengue virus (DENV) has emerged as major human pathogen. Despite the serious socio-economic impact of DENV-associated diseases, antiviral therapy is missing. DENV replicates in the cytoplasm of infected cells and induces a membranous replication organelle, formed by invaginations of the endoplasmic reticulum membrane and designated vesicle packets (VPs). Nonstructural protein 1 (NS1) of DENV is a multifunctional protein. It is secreted from cells to counteract antiviral immune responses, but also critically contributes to the severe clinical manifestations of dengue. In addition, NS1 is indispensable for viral RNA replication, but the underlying molecular mechanism remains elusive. In this study, we employed a combination of genetic, biochemical and imaging approaches to dissect the determinants in NS1 contributing to its various functions in the viral replication cycle. Several important observations were made. First, we identified a cluster of amino acid residues in the exposed region of the β-ladder domain of NS1 that are essential for NS1 secretion. Second, we revealed a novel interaction of NS1 with the NS4A-2K-4B cleavage intermediate, but not with mature NS4A or NS4B. This interaction is required for RNA replication, with two residues within the connector region of the NS1 “Wing” domain being crucial for binding of the NS4A-2K-4B precursor. By using a polyprotein expression system allowing the formation of VPs in the absence of viral RNA replication, we show that the NS1 –NS4A-2K-4B interaction is not required for VP formation, arguing that the association between these two proteins plays a more direct role in the RNA amplification process. Third, through analysis of polyproteins containing deletions in NS1, and employing a trans-complementation assay, we show that both cis and trans acting elements within NS1 contribute to VP formation, with the capability of NS1 mutants to form VPs correlating with their capability to support RNA replication. In conclusion, these results reveal a direct role of NS1 in VP formation that is independent from RNA replication, and argue for a critical function of a previously unrecognized NS4A-2K-NS4B precursor specifically interacting with NS1 and promoting viral RNA replication.
Types and Basic Properties of Leaky Modes in Microwave and Millimeter-Wave Integrated Circuits

Leaky waves have been known for many years in the context of leaky-wave antennas, but it is only within the past dozen years or so that it was realized that the dominant mode on printed-circuit transmission lines used in microwave and millimeter-wave integrated circuits can also leak. Such leakage is extremely important because it may cause power loss, cross talk between neighboring parts of the circuit, and various undesired package effects. These effects can ruin the performance of the circuit, so we must know when leakage can occur and how to avoid it. In most cases, these transmission lines leak only at high frequencies, but some lines leak at all frequencies. However, those lines can be modified to avoid the leakage. This paper explains why and when leakage occurs, and shows how the dominant mode behaves on different lines. The paper also examines certain less well known but important features involving unexpected new physical effects. These include an additional dominant mode on microstrip line that is leaky at higher frequencies, and a simultaneous propagation effect, which is rather general and which occurs when the line’s relative cross-sectional dimensions are changed. The final section of the paper is concerned with three important recent developments: (a) the new effects that arise when the frequency is raised still higher and leakage occurs into an additional surface wave, (b) a basic and unexpected discovery relating to improper real modes, which are nonphysical but which can strongly influence the total physical field under the right circumstances, and (c) the important practical issue of how leakage behavior is modified when the circuit is placed into a package. key words: leakage into surface waves, microwave and