Miracle-dz/UniFAR-FTUs huggingface dataset:
MRI Inner Ear Imaging and Tone Burst Electrocochleography in the Diagnosis of Ménière’s Disease

Objective To compare the sensitivity of gadolinium MRI inner imaging with tone burst electrocochleography (EcochG) for diagnosing endolymphatic hydrops. Study Design A prospective study on patients who were to have an MRI scan to exclude retrocochlear pathology. Setting Tertiary care center. Patients One hundred and two patients: 57 patients with Possible, Probable, or Definite Ménière’s Disease, 25 with asymmetrical hearing loss, 18 with sudden sensorineural hearing loss, and 2 with unilateral tinnitus had additional MRI inner ear imaging and click and tone burst stimulus EcochG testing. Intervention Diagnostic. Main Outcome Measure To compare the sensitivity of the two techniques. Results In 30 patients with symptom-based Definite Ménière’s Disease, tone burst EcochG was positive in 25 (83%) and the click EcochG was positive in 9/30 (30%), and gadolinium MRI imaging diagnosed hydrops in 14 (47%). A positive result for either MRI imaging or tone burst EcochG was seen in 26 patients (87%). In 14 subjects with symptom-based Probable Ménière’s Disease, 10 (71%) had either a positive EcochG or MRI. In 13 with Possible Ménière’s Disease, four (31%) had a positive EcochG or MRI. Conclusion This study confirms the greatly enhanced diagnostic sensitivity of tone burst EcochG over click response in diagnosing endolymphatic hydrops in Ménière’s disease. Even though adequate MRI imaging was achieved in 90%, tone burst EcochG was a more sensitive test.
Meeting the Challenge of Reconstruction and Development in Fragile States: Lessons from Aceh, Haiti, and South Sudan

Reconstruction and development in poor, fragile countries present a double challenge: tackling the issues of poverty and underdevelopment as well as the constraints posed by instability, poor governance, and weak capacity. This context generates a range of problems that include: insecurity, insufficient planning, inadequate implementation capacity, poor financial management, misprocurement, corruption, a volatile fiscal environment, ineffective donor coordination, and negative environmental and social impacts. The paper draws lessons from positive and negative experiences in meeting these challenges in three conflictand/or disaster-affected cases: Aceh Province, Indonesia (postdisaster reconstruction and postconflict development following the tsunami and earthquakes of 2004), Haiti (postdisaster recovery following the earthquake of 2010), and South Sudan (postconflict development following independence in 2011). These lessons are then organized in an assessment framework of risks and mitigation measures to assist academics and practitioners to understand and address the challenges of reconstruction and development in fragile states.
Predicting custodial suicides: Problems with the use of profiles

Although the problem of jail and lockup suicides is nationwide, this social problem has begun only recently to receive the scholarly attention it warrants. A number of studies have advanced profiles of the typical jail suicide, but noncritical applications of these profiles may lead to problems if practitioners are unaware of their limitations. Different profiles often are mutually contradictory and seem to be more postdictive than predictive. Other problems include the potential for false positives, selective inattention, and the exposure of correctional authorities to inappropriate tort liability. Jail and lockup suicide data from Michigan for 1980–1985 were used to examine the implications of reliance on published suicide profiles. Only seven of 80 suicides were found to fit a national profile completely, while nine suicides would have been totally unexpected. It was concluded that because of the differences between various jail environments and inmate populations, it is unlikely that even a methodolog.
Intestinal epithelial cell signalling and host‐derived negative regulators under chronic inflammation: to be or not to be activated determines the balance towards commensal bacteria

Abstract Advancing knowledge regarding the cellular mechanisms of intestinal inflammation has led to a better understanding of the disease pathology in patients with chronic disorders of the gut including inflammatory bowel disease, coeliac disease, lymphocytic colitis and irritable bowel syndrome. An emerging new paradigm suggests that changes in the homeostasis of bacteria‐ and host‐derived signal transduction at the epithelial cell level may lead to functional and immune disturbances of the intestinal epithelium. It has become clear from numerous studies that enteric bacteria are a critical component in the development and prevention/treatment of chronic intestinal inflammation. Signal‐specific activation of mitogen‐activated protein kinases (MAPK), interferon‐regulated factors (IRF) and the transcription factor NF‐κB through pattern recognition receptor signalling effectively induce inflammatory defence mechanisms. Unbalanced activation of these innate signalling pathways because of host genetic predispositions and/or the lack of adequate anti‐inflammatory feedback mechanisms may turn a physiological response into a pathological situation including failure of bacterial clearance and development of chronic inflammation. Host‐derived regulators from the immune and enteric nerve system crosstalk to the innate signalling network of the intestinal epithelium in order to shape the extent and duration of inflammatory processes.
Changes of AM Fungal Abundance along Environmental Gradients in the Arid and Semi-Arid Grasslands of Northern China

Arbuscular mycorrhizal (AM) fungi are ubiquitous symbionts of higher plants in terrestrial ecosystems, while the occurrence of the AM symbiosis is influenced by a complex set of abiotic and biotic factors. To reveal the regional distribution pattern of AM fungi as driven by multiple environmental factors, and to understand the ecological importance of AM fungi in natural ecosystems, we conducted a field investigation on AM fungal abundance along environmental gradients in the arid and semi-arid grasslands of northern China. In addition to plant parameters recorded in situ, soil samples were collected, and soil chemo-physical and biological parameters were measured in the lab. Statistical analyses were performed to reveal the relative contribution of climatic, edaphic and vegetation factors to AM fungal abundance, especially for extraradical hyphal length density (HLD) in the soil. The results indicated that HLD were positively correlated with mean annual temperature (MAT), soil clay content and soil pH, but negatively correlated with both soil organic carbon (SOC) and soil available N. The multiple regressions and structural equation model showed that MAT was the key positive contributor and soil fertility was the key negative contributor to HLD. Furthermore, both the intraradical AM colonization (IMC) and relative abundance of AM fungi, which was quantified by real-time PCR assay, tended to decrease along the increasing SOC content. With regard to the obvious negative correlation between MAT and SOC in the research area, the positive correlation between MAT and HLD implied that AM fungi could potentially mitigate soil carbon losses especially in infertile soils under global warming. However, direct evidence from long-term experiments is still expected to support the AM fungal contribution to soil carbon pools.
Ethnolinguistic vitality and language use amongst Eastern European migrants in East Anglia

Abstract This paper discusses language usage patterns amongst Eastern European migrants living in the East Anglia region of Great Britain. It examines the relationship between individual speakers' language use and societal factors, with an emphasis of respondents' perceptions of ethnic, cultural and linguistic vitality. A linguistic vitality and language usage questionnaire adapted from Yagmur, and Yagmur and Akinci, capturing domain-specific language use as well as respondents' perception of their own and other ethnolinguistic groups, was completed by 58 migrants from new European Union member states. Data analysis uncovers three themes: first, language use is domain-specific, with preferences for the L1 in the home/family domain only, and L2 English being the language of choice elsewhere; second, there are low perceptions of ethnolinguistic vitality of the L1 group across the sample; and third, there is initial evidence for a potential longitudinal shift in language use as a result of an integrative attitude to migration by the respondents and long-term plans to reside in the UK from the outset.
CEO and Board Characteristics as Determinants of Private Benefits of Control: Evidence from the Russian Stock Exchange

This paper investigates whether and how various characteristics of CEOs and corporate boards are related to the severity of corporate governance problems within firms. The latter is proxied by private benefits of control, which we measure for dual class stock firms using the voting premium approach. Our empirical analysis is based on data from Russia and takes advantage of the extreme corporate governance problems in the country, considerable variation in corporate governance practices across firms and over time, and presence of a large and exogenously created (during the process of privatization) group of dual class stock companies. The data are assembled from the RTS, SKRIN and SPARK databases and include over 200 firms observed in 1997-2009, with over 1000 observations in total. Our econometric analysis suggests a quadratic relationship between private benefits of control and CEO ownership with a minimum at about 4% CEO ownership, a positive association between CEO tenure and private benefits, and a quadratic in CEO age with a dip in private benefits at about 52 years of age. There is also a quadratic relationship between private benefits of control and board size, implying the optimality of medium-sized (about 9-10 directors) boards. We find no gender effects on private benefits of control.
Assessing Print Exposure and Orthographic Processing Skill in Children: A Quick Measure of Reading Experience.

In a study of third- and fourth-grade children it was established that orthographic processing ability can account for variance in word recognition skill after the variance due to phonological processing has been partialed out. This independent orthographic variances was related to performance on a new measure of individual differences in exposure to print, the Title Recognition Test (TRT), that has a very brief administration time. Additionally, some of the orthographic processing variance linked to word recognition ability was not shared with either phonological processing measures or with print exposure
An Expert System For Interpreting Mesoscale Features In Oceanographic Satellite Images

Thermal infrared images of the ocean obtained from satellite sensors are widely used for the study of ocean dynamics. The derivation of mesoscale ocean information from satellite data depends to a large extent on the correct interpretation of infrared oceanographic images. The difficulty of the image analysis and understanding problem for oceanographic images is due in large part to the lack of precise mathematical descriptions of the ocean features, coupled with the time varying nature of these features and the complication that the view of the ocean surface is typically obscured by clouds, sometimes almost completely. Towards this objective, the present paper describes a hybrid technique that utilizes a nonlinear probabilistic relaxation method and an expert system for the oceanographic image interpretation problem. A unified mathematical framework that helps in solving the problem is presented. This paper highlights the advantages of using the contextual information in the feature labeling algorithm. The paper emphasizes the need for the feedback from the high level modules to the intermediate modules in an automatic image interpretation system. The paper presents some important results of the series of experiments conducted at Remote Sensing Branch, NORDA, on the NOAA AVHRR imagery data. Key words: feature labeling, feature extraction, oceanic features, edge detection, knowledge based systems, expert system, relaxation, infrared imagery.
Snake robot obstacle aided locomotion: An experimental validation of a non-smooth modeling approach

The paper considers the problem of obstacle aided locomotion for snake robots, as taking advantage of obstacles for locomotion is an enabling technique for snake robots to enter challenging environments like earthquaked areas and mines for search and rescue missions. To this end, the paper presents a novel non-smooth (hybrid) 2D mathematical model for snake robots which incorporates that the snake robot can come in contact with external obstacles apart from flat ground. The mathematical model is verified through a back-to-back comparison between numerical simulations and experimental results. It is furthermore shown that the snake robot is able to move forward faster and more robustly by exploiting obstacles, and that the locomotion in this case is not as dependent on the ground surface.
EU marker polycyclic aromatic hydrocarbons in food supplements: analytical approach and occurrence

Several food supplements comprising botanical, oil and bee products collected from retail markets in different countries were tested for the occurrence of 4 EU marker Polycyclic aromatic hydrocarbons (PAHs; benz[a]anthracene, chrysene, benzo[b]fluoranthene and benzo[a]pyrene). A robust GC/MS-based stable-isotope dilution method was used taking into account the differences in the type of matrices. The accuracy of the results was assessed by implementing several quality control tools. Sixty-eight samples of 94 analysed products exceeded the level of 0.5 μg/kg for the sum of the four EU marker PAHs (ΣPAH4). Benzo[a]pyrene exceeded the limit of quantification in 49 samples. The PAH with the highest abundance in all products was chrysene. On average, propolis extracts and other bee products showed relatively high levels of ΣPAH4 (mean 188.2 μg/kg), whereas the contamination levels of fish oil supplements were very low or mostly undetectable. Considerably high ΣPAH4 amounts found in some samples could remarkably increase the daily exposure of consumers to PAHs, demonstrating the need for continuous monitoring of ΣPAH4 in food supplements. Graphical Abstract
Low Molecular Weight Heparin in Obstetric Care

Low molecular weight heparins (LMWHs) are widely used during pregnancy since several randomized controlled trials have demonstrated their important role in preventing not only thromboembolic disease but also pregnancy complications associated with thrombophilia: recurrent pregnancy loss (RPL), fetal growth restriction (FGR), preeclampsia (PE), abruptio placentae and intrauterine fetal death (IUFD). LMWHs have revealed their effectiveness in reducing the recurrence of negative obstetrics events even in patients without known trombophilias, despite the mechanisms whereby LMWHs operate remain still unclear. However, in order to confirm the suggested benefits, adequately powered and properly controlled trials are needed in this area. Such trials are currently underway and their results will be important to inform evidence-based practice in this area. In our review we report the results of the most relevant trials performed to assess the efficacy of LMWHs in preventing pregnancy complications associated or not with maternal thrombophilia. This review was conducted based on a MEDLINE search for relevant articles between January 2000 and August 2010 and using the following search terms: heparin, low molecular weight heparin, thrombophilia, pregnancy complications, preeclampsia, recurrent pregnancy loss, abruptio placentae, fetal growth restriction.
Altered BOLD Response during Inhibitory and Error Processing in Adolescents with Anorexia Nervosa

Background Individuals with anorexia nervosa (AN) are often cognitively rigid and behaviorally over-controlled. We previously showed that adult females recovered from AN relative to healthy comparison females had less prefrontal activation during an inhibition task, which suggested a functional brain correlate of altered inhibitory processing in individuals recovered from AN. However, the degree to which these functional brain alterations are related to disease state and whether error processing is altered in AN individuals is unknown. Methodology/Principal Findings In the current study, ill adolescent AN females (n = 11) and matched healthy comparison adolescents (CA) with no history of an eating disorder (n = 12) performed a validated stop signal task (SST) during functional magnetic resonance imaging (fMRI) to explore differences in error and inhibitory processing. The groups did not differ on sociodemographic variables or on SST performance. During inhibitory processing, a significant group x difficulty (hard, easy) interaction was detected in the right dorsal anterior cingulate cortex (ACC), right middle frontal gyrus (MFG), and left posterior cingulate cortex (PCC), which was characterized by less activation in AN compared to CA participants during hard trials. During error processing, a significant group x accuracy (successful inhibit, failed inhibit) interaction in bilateral MFG and right PCC was observed, which was characterized by less activation in AN compared to CA participants during error (i.e., failed inhibit) trials. Conclusion/Significance Consistent with our prior findings in recovered AN, ill AN adolescents, relative to CA, showed less inhibition-related activation within the dorsal ACC, MFG and PCC as inhibitory demand increased. In addition, ill AN adolescents, relative to CA, also showed reduced activation to errors in the bilateral MFG and left PCC. These findings suggest that altered prefrontal and cingulate activation during inhibitory and error processing may represent a behavioral characteristic in AN that is independent of the state of recovery.
Selective Processing of Threatening Words in Anxiety: The Role of Awareness

In three experiments, high and low trait-anxious individuals were required to classify a centrally located number as odd or even while ignoring spatially separate threat-related or neutral words. It was found that high anxious subjects showed a selective bias to process threatening stimuli when the stimuli were pattern masked after a brief exposure (14msec). However, this automatic processing bias was apparent only under certain conditions: distractors were within focal attention; masked and unmasked distractors were randomly intermixed; or masked trials were presented after unmasked trials. These results suggest that automatic processing biases in high traitanxious individuals are influenced by contextual factors. There was also a suggestion of a qualitative difference in attentional bias between conscious (unmasked) and nonconscious (masked) states, providing evidence for perception without awareness. The theoretical implications of these results are discussed.
Responses of Angiogenic Growth Factors to Exercise, to Hypoxia and to Exercise under Hypoxic Conditions

Abstract The purpose of the present study was to compare the acute hormonal response of angiogenic regulators to a short-term hypoxic exposure at different altitudes with and without exercise. 7 subjects participated in 5 experimental trials. 2 times subjects stayed in a sedentary position for 90 min at 2 000 m or 4 000 m, respectively. The same was carried out again in combination with exercise at the same relative intensity (2 mmol∙L − 1 of lactate). The fifth trial consisted of 90 min exercise at sea level. Venous blood samples were taken under resting conditions, 0 and 180 min after each condition to determine VEGF, EPO, IL-6, IL-8 and IGF-1 serum concentrations. EPO, VEGF, and IL-8 showed increases only, when hypoxia was combined with exercise. IL-6 was increased after exercise, independent of altitude. IGF-1 showed no changes in any intervention. The present study suggests that short term hypoxic exposure combined with low intensity exercise is able to up-regulate angiogenic regulators, which might be beneficial to induce angiogenesis and to improve endurance performance. However, in some cases high altitudes are needed, or it can be speculated that exercise intensity needs to be increased.
Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2

The nfkb2 gene encodes the p100 precursor which produces the p52 protein after proteolytic cleavage of its COOH-terminal domain. Although the p52 product can act as an alternative subunit of NF-κB, the p100 precursor is believed to function as an inhibitor of Rel/NF-κB activity by cytoplasmic retention of Rel/NF-κB complexes, like other members of the IκB family. However, the physiological relevance of the p100 precursor as an IκB molecule has not been understood. To assess the role of the precursor in vivo, we generated, by gene targeting, mice lacking p100 but still containing a functional p52 protein. Mice with a homozygous deletion of the COOH-terminal ankyrin repeats of NF-κB2 (p100−/−) had marked gastric hyperplasia, resulting in early postnatal death. p100−/− animals also presented histopathological alterations of hematopoietic tissues, enlarged lymph nodes, increased lymphocyte proliferation in response to several stimuli, and enhanced cytokine production in activated T cells. Dramatic induction of nuclear κB–binding activity composed of p52-containing complexes was found in all tissues examined and also in stimulated lymphocytes. Thus, the p100 precursor is essential for the proper regulation of p52-containing Rel/NF-κB complexes in various cell types and its absence cannot be efficiently compensated for by other IκB proteins.
Parent partnership and ‘quality’ early years services: practitioners' perspectives

ABSTRACT This article begins by outlining the historical and political context of ‘parent partnership’ within the UK. It locates the perspectives of early years' practitioners within this context, drawing on data from an Economic and Social Research Council (ESRC)-funded study of eighteen English early years settings, including interviews and focus groups with 165 practitioners in a variety of roles. The findings reveal that, although all practitioners considered parent partnership to be an essential element in quality early years services, the partnerships themselves were understood and enacted in very different ways. Practitioners appear to be influenced by dominant policy discourses as well as their personal and professional histories and their perceptions of the purposes and priorities of their setting. In discussing the nature of ‘parent partnership’, we focus on tensions inherent in English policy discourses, reflecting on the previous Labour government policy as well as changes introduced by the current Coalition government.