Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of dalcetrapib in patients with a recent acute coronary syndrome.

BACKGROUND In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events. However, whether raising HDL cholesterol levels therapeutically reduces cardiovascular risk remains uncertain. Inhibition of cholesteryl ester transfer protein (CETP) raises HDL cholesterol levels and might therefore improve cardiovascular outcomes. METHODS We randomly assigned 15,871 patients who had had a recent acute coronary syndrome to receive the CETP inhibitor dalcetrapib, at a dose of 600 mg daily, or placebo, in addition to the best available evidence-based care. The primary efficacy end point was a composite of death from coronary heart disease, nonfatal myocardial infarction, ischemic stroke, unstable angina, or cardiac arrest with resuscitation. RESULTS At the time of randomization, the mean HDL cholesterol level was 42 mg per deciliter (1.1 mmol per liter), and the mean low-density lipoprotein (LDL) cholesterol level was 76 mg per deciliter (2.0 mmol per liter). Over the course of the trial, HDL cholesterol levels increased from baseline by 4 to 11% in the placebo group and by 31 to 40% in the dalcetrapib group. Dalcetrapib had a minimal effect on LDL cholesterol levels. Patients were followed for a median of 31 months. At a prespecified interim analysis that included 1135 primary end-point events (71% of the projected total number), the independent data and safety monitoring board recommended termination of the trial for futility. As compared with placebo, dalcetrapib did not alter the risk of the primary end point (cumulative event rate, 8.0% and 8.3%, respectively; hazard ratio with dalcetrapib, 1.04; 95% confidence interval, 0.93 to 1.16; P=0.52) and did not have a significant effect on any component of the primary end point or total mortality. The median C-reactive protein level was 0.2 mg per liter higher and the mean systolic blood pressure was 0.6 mm Hg higher with dalcetrapib as compared with placebo (P<0.001 for both comparisons). CONCLUSIONS In patients who had had a recent acute coronary syndrome, dalcetrapib increased HDL cholesterol levels but did not reduce the risk of recurrent cardiovascular events. (Funded by F. Hoffmann-La Roche; dal-OUTCOMES ClinicalTrials.gov number, NCT00658515.).
Hyperactivity of ON-Type Retinal Ganglion Cells in Streptozotocin-Induced Diabetic Mice

Impairment of visual function has been detected in the early stage of diabetes but the underlying neural mechanisms involved are largely unknown. Morphological and functional alterations of retinal ganglion cells, the final output neurons of the vertebrate retina, are thought to be the major cause of visual defects in diabetes but direct evidence to support this notion is limited. In this study we investigated functional changes of retinal ganglion cells in a type 1-like diabetic mouse model. Our results demonstrated that the spontaneous spiking activity of ON-type retinal ganglion cells was increased in streptozotocin-diabetic mice after 3 to 4 months of diabetes. At this stage of diabetes, no apoptotic signals or cell loss were detected in the ganglion cell layer of the retina, suggesting that the functional alterations in ganglion cells occur prior to massive ganglion cell apoptosis. Furthermore, we found that the increased activity of ON-type ganglion cells was mainly a result of reduced inhibitory signaling to the cells in diabetes. This novel mechanism provides insight into how visual function is impaired in diabetic retinopathy.
Suboptimal and Anytime Heuristic Search on Multi-Core Machines

In order to scale with modern processors, planning algorithms must become multi-threaded. In this paper, we present parallel shared-memory algorithms for two problems that underlie many planning systems: suboptimal and anytime heuristic search. We extend a recently-proposed approach for parallel optimal search to the suboptimal case, providing two new pruning rules for bounded suboptimal search. We also show how this new approach can be used for parallel anytime search. Using temporal logic, we prove the correctness of our framework, and in an empirical comparison on STRIPS planning, grid pathfinding, and sliding tile puzzle problems using an 8-core machine, we show that it yields faster search performance than previous proposals.
Modeling and Preventive Measures of Hand, Foot and Mouth Disease (HFMD) in China

This paper concentrates on the HFMD data of China from March 2009 to December 2012. We set up a mathematical model to fit those data with the goodness of fit and obtain the optimal parameter values of the model. By the Chi-square test of statistical inference, the optimal parameter values of the model are reasonable. We obtained the basic reproductive number of the disease for each year, and it is larger than 1. Thus, we conclude that HFMD will persist in China under the current conditions, so we investigate the preventive measures to control the HFMD. If the preventive measures proposed in our paper were implemented, HFMD would be controlled quickly and the number of infections would decline rapidly over a period of time.
Partial Monitoring - Classification, Regret Bounds, and Algorithms

In a partial monitoring game, the learner repeatedly chooses an action, the environment responds with an outcome, and then the learner suffers a loss and receives a feedback signal, both of which are fixed functions of the action and the outcome. The goal of the learner is to minimize his regret, which is the difference between his total cumulative loss and the total loss of the best fixed action in hindsight. In this paper we characterize the minimax regret of any partial monitoring game with finitely many actions and outcomes. It turns out that the minimax regret of any such game is either zero or scales as T1/2, T2/3, or T up to constants and logarithmic factors. We provide computationally efficient learning algorithms that achieve the minimax regret within a logarithmic factor for any game. In addition to the bounds on the minimax regret, if we assume that the outcomes are generated in an i.i. d. fashion, we prove individual upper bounds on the expected regret.
Distinguishing Subtypes of Multiword Expressions Using Linguistically-Motivated Statistical Measures

We identify several classes of multiword expressions that each require a different encoding in a (computational) lexicon, as well as a different treatment within a computational system. We examine linguistic properties pertaining to the degree of semantic idiosyncrasy of these classes of expressions. Accordingly, we propose statistical measures to quantify each property, and use the measures to automatically distinguish the classes.
A simplified method for monitoring heparin therapy at the bedside: The activated whole blood clotting time

Twelve patients receiving heparin during hemodialysis had coagulation parameters monitored using the whole blood clotting time (WBCT), activated partial thromboplastin time (APTT), plasma heparin levels and activated whole blood clotting time (AWBCT). The AWBCT, performed with a battery‐powered portable incubator/timer, correlated with both the corresponding WBCT and the plasma heparin levels. However, the correlation between the AWBCT and the APTT was quite poor. This assay is simply performed, inexpensive, and reproducible. It is recommended as an excellent method for monitoring heparin therapy.
A fibronectin-fibrinogen-tropoelastin coating reduces smooth muscle cell growth but improves endothelial cell function

Reendothelialization of the stent surface after percutaneous coronary intervention (PCI) is known to be an important determinant of clinical outcome. We compared the effects of biological stent coatings, fibronectin, fibrinogen and tropoelastin, on human umbilical vein endothelial cell (HUVEC) and vascular smooth muscle cell (VSMC) characteristics. Umbilical cord arterial segments were cultured on coated surfaces and VSMC outgrowth (indicating proliferation and migration) was measured after 12 days. mRNA was isolated from HUVEC and VSMC cultured on these coatings and gene expression was profiled by QPCR. Procoagulant properties of HUVEC were determined by an indirect chromogenic assay which detects tissue factor activity. The varying stent coatings influence VSMC outgrowth: 31.2 ± 4.0 mm2 on fibronectin, 1.6 ± 0.3 mm2 on tropoelastin and 8.1 ± 1.5 mm2 on a mixture of fibronectin/fibrinogen/tropoelastin, although HUVEC migration remains unaffected. Culturing HUVEC on tropoelastin induces increased expression of VCAM‐1 (13.1 ± 4.4 pg/ml), ICAM‐1 (5.1 ± 1.3 pg/ml) and IL‐8 (11.6 ± 3.1 pg/ml) compared to fibronectin (0.7 ± 0.2, 0.8 ± 0.2, 2.3 ± 0.5 pg/ml, respectively), although expression levels on fibronectin/fibrinogen/tropoelastin remain unaltered. No significant differences in VCAM‐1, ICAM‐1 and IL‐8 mRNA expression are found in VSMC. Finally, HUVEC cultured on tropoelastin display a fivefold increased tissue factor activity (511.6 ± 26.7%), compared to cells cultured on fibronectin (100 ± 3.9%) or fibronectin/fibrinogen/tropoelastin (76.3 ± 25.0%). These results indicate that tropoelastin inhibits VSMC migration but leads to increased inflammatory and procoagulant markers on endothelial cells. Fibronectin/fibrinogen/tropoelastin inhibits VSMCs while compensating the inflammatory and procoagulant effects. These data suggest that coating a mixture of fibronectin/fibrinogen/tropoelastin on a stent may promote reendothelialization, while keeping unfavourable processes such as restenosis and procoagulant activity limited.
Leukocyte‐specific protein 1 links TNF receptor‐associated factor 1 to survival signaling downstream of 4‐1BB in T cells

4‐1BB is a member of the TNFR superfamily, which contributes to the activation of signaling pathways required for the survival of activated and memory T cells. We have shown previously that TRAF1, an adaptor protein recruited to 4‐1BB, is required for 4‐1BB‐mediated CD8 T cell survival in vivo. With the use of a proteomics approach in primary T cells, we have identified LSP1 as a novel protein recruited to the 4‐1BB signaling complex in a TRAF1‐dependent manner. Further characterization of the interaction between TRAF1 and LSP1 revealed that LSP1 requires the TRAF‐N domain of TRAF1 for direct association. Similarly to TRAF1−/− T cells, LSP1−/− T cells exhibit impaired ERK activation following stimulation through 4‐1BB and consequently, are unable to down‐modulate expression of the proapoptotic Bcl‐2 family member Bim. Moreover, we demonstrate that the absence of LSP1 expression leads to defective expansion and survival of T cells in response to 4‐1BB stimulation. Thus, we have identified LSP1 as a new mediator involved in 4‐1BB signaling and T cell survival. Collectively, our work shows that TRAF1 and LSP1 cooperate downstream of 4‐1BB to activate ERK signaling and down‐modulate the levels of Bim leading to enhanced T cell survival.
When Reputation Engenders Trust: An Empirical Investigation in Business-to-Consumer Electronic Commerce

Consumers' enhanced risk perception is an important challenge to bemet in electronic commerce. The research presented here casts new light onthe concept of trust, which is a vital mechanism when it comes to reduce perceivedrisk. Trust is conceptualized as a multi? dimensional concept comprisedof a person's trusting attitudes toward the vendor, the system and theself as well as his or her trusting intention to buy from a vendor on theInternet. Based upon an online survey among 473 German Internet users, theinterrelationships between the dimensions of trust and the influential roleof a vendor's as well as the system's reputation to engender trustis analysed. Results show that a person's trusting intention is moststrongly influenced by a person's trusting attitude toward the vendor.The role of reputation to enhance trust is particularly pronounced if theconsumer's experience with a particular vendor or the Internet as a shopping environment in general are low. Implications of the research findings are discussed.
Ruminant Gastrointestinal Cell Proliferation and Clearance of Escherichia coli O157:H7

ABSTRACT Human infections with Escherichia coli O157:H7 cause hemorrhagic colitis that can progress to a life-threatening sequelae. The most common mode of disease transmission is ingestion of contaminated bovine food products, and it is well established thatE. coli O157:H7 is a transient member of the bovine microbiota. However, the conditions that induce acquisition and subsequent clearance of this bacterium from the ruminant gastrointestinal tract (GIT) are not understood. Evidence that the rates of epithelial cell proliferation in the lower GIT of cattle are associated with the duration animals remained E. coliO157:H7 culture positive is presented. Cattle with slower rates of intestinal cell proliferation in the cecum and the distal colon were culture positive significantly longer than cohort cattle with faster cell proliferation rates. Cell death rates (apoptotic indices) between the short- and long-term culture-positive animals were not different. Typical grain-based finishing diets and forage-based growing diets did not effect GIT cell proliferation or the duration animals remained E. coli O157:H7 culture positive. To identify a dietary intervention that would effect GIT cell proliferation, we used sheep as a model ruminant. A fasting-refeeding regime that increased the rate of GIT cell proliferation was developed. The fasting-refeeding protocol was used in cattle to test the hypothesis that feeding interventions that increase the rate of GIT cell proliferation induce the clearance of E. coli O157:H7 from the bovine GIT.
Ultrastructure and Morphology of Compound Eyes of the Scorpionfly Panorpa dubia (Insecta: Mecoptera: Panorpidae)

Mecoptera are unique in holometabolous insects in that their larvae have compound eyes. In the present study the cellular organisation and morphology of the compound eyes of adult individuals of the scorpionfly Panorpa dubia in Mecoptera were investigated by light, scanning electron, and transmission electron microscopy. The results showed that the compound eyes of adult P. dubia are of the apposition type, each eye comprising more than 1200 ommatidia. The ommatidium consists of a cornea, a crystalline cone made up of four cone cells, eight photoreceptors, two primary pigment cells, and 18 secondary pigment cells. The adult ommatidium has a fused rhabdom with eight photoreceptors. Seven photoreceptors extend from the proximal end of the crystalline cone to the basal matrix, whereas the eighth photoreceptor is shorter, extending from the middle level of the photoreceptor cluster to the basal matrix. The fused rhabdom is composed of the rhabdomeres of different photoreceptors at different levels. The adult ommatidia have the same cellular components as the larval ommatidia, but the tiering scheme is different.
Experimental Studies and Analysis of Alfvén Eigenmodes in Alcator

Alfvén cascades (ACs) or equivalently, reverse shear Alfvén eigenmodes (RSAE) have been observed in Alcator C-Mod during current ramp experiments in the presence of intense ICRF driven energetic minority tails. These experiments were carried out at ITER relevant densities and magnetic field. Phase contrast imaging (PCI) and magnetic pick-up coils have been used for detecting the Alfvén eigenmodes. The chirping evolution (increasing in time) of the frequency spectrum has allowed us to deduce the temporal evolution of the reversed shear q-profile. Numerical results from the latest version of the NOVA-K MHD code, including finite pressure reproduces the experimental measurements, including the minimum frequency. The harmonic of the cascade frequency was also observed by the diagnostics. In a different set of C-Mod experiments a pair of active MHD antennas were used to excite ITER relevant intermediate toroidal mode number (3 < n < 14) toroidal Alfvén eigenmodes (TAE), and their measured weak damping rates indicate that such modes may be excited by alpha particles in ITER. We have also studied the feasibility of adding PCI detection optics outside the ITER vessel that shares the CO2 laser interferometer port hardware. Implementing PCI on ITER would greatly extend our capabilities to assess the importance of Alfvén mode excitation on alpha particle confinement. 1. Experimental Results. Plasma experiments with ICRF heating during the current-ramp and diffusion phase have produced frequency chirping modes known as Alfvén cascades (AC), or reverse shear Alfvén eigenmodes (RSAE). These modes exist only in the presence of a very flat or hollow current distribution, residing in the vicinity of the minimum of the q profile. An analytic expression describing the frequency of the modes is taken from Ref. [1] as
Exploiting emotions to disambiguate dialogue acts

This paper describes an attempt to reveal the user's intention from dialogue acts, thereby improving the effectiveness of natural interfaces to pedagogical agents. It focuses on cases where the intention is unclear from the dialogue context or utterance structure, but where the intention may still be identified using the emotional state of the user. The recognition of emotions is based on physiological user input. Our initial user study gave promising results that support our hypothesis that physiological evidence of emotions could be used to disambiguate dialogue acts. This paper presents our approach to the integration of natural language and emotions as well as our first empirical results, which may be used to endow interactive agents with emotional capabilities.
Parenting experiences of couples living with human immunodeficiency virus: A qualitative study from rural Southern Malawi

Abstract The advent of antiretroviral therapy (ART) has allowed couples living with human immunodeficiency virus (HIV) to live longer and healthier lives. The reduction in the mother-to-child transmission of HIV has encouraged some people living with HIV (PLWH) to have children. However, little is known about the parenting experiences of couples living with HIV (CLWH). The aim of this qualitative study was to explore and describe parenting experiences of seroconcordant couples who have a child while living with HIV in Malawi. Data were collected using in-depth interviews with 14 couples purposively sampled in matrilineal Chiradzulu and patrilineal Chikhwawa communities from July to December 2010. The research findings shows that irrespective of kinship organization, economic hardships, food insecurity, gender-specific role expectations and conflicting information from health institutions and media about sources of support underpin their parenting roles. In addition, male spouses are directly involved in household activities, childcare and child feeding decisions, challenging the existing stereotyped gender norms. In the absence of widow inheritance, widows from patrilineal communities are not receiving the expected support from the deceased husband relatives. Finally, the study has shown that CLWH are able to find solutions for the challenges they encounter. Contrary to existing belief that such who have children depend solely on public aid. Such claims without proper knowledge of local social cultural contexts, may contribute to stigmatizing CLWH who continue to have children. The study is also relevant to PLWH who, although not parents themselves, are confronted with a situation where they have to accept responsibility for raising children from their kin. We suggest the longer-term vision for ART wide access in Malawi to be broadened beyond provision of ART to incorporate social and economic interventions that support the rebuilding of CLWH social and economic lives. The interventions must be designed using a holistic multi-sector approach.
Effect of the Ratio of Raw Material Components on the Physico-chemical Characteristics of Emulsion-type Pork Sausages

This study was conducted to investigate the effects of raw material ratio on the physicochemical characteristics of emulsion-type pork sausages. Experiment design was divided into 12 treatments, based on protein level (P), fat level (3P, 3.5P, and 4P), and water level (4P+10, 4P+15, 4P+20, and 4P+25). The pH and shear force values were significantly higher in T7 (3.5P fat and 4P+20 water) than those of other treatments. The lightness and redness were greatly reduced by increasing the quantity of water. The treatments containing 3P fat and 4P+20 water had the highest values of cohesiveness, springiness, gumminess, and chewiness. On the whole, when the protein (P) and fat (3P, 3.5P, 4P) levels were fixed, an increase over the appropriate moisture level deteriorated many physicochemical characteristics.
Response of human jaw muscles to axial stimulation of the incisor

The role of periodontal mechanoreceptors (PMRs) in the reflex control of the jaw muscles has thus far been mainly derived from animal studies. To date, the work that has been done on humans has been limited and confined to orthogonal stimulation of the labial surface of the tooth. The purpose of this study was to investigate the response of the masseter and digastric muscles in humans to controlled axial stimulation of the upper left central incisor, both before and during a local anaesthetic block of the PMRs. Ten neurologically normal young adult females were tested, each on two separate occasions to confirm the reproducibility of the results. It was found that the reflex response in the masseter was modulated by the rate of rise of the stimulus used and, to a lesser degree, the level of background muscle activity. There was little detectable change in the activity of the digastric muscle under the tested conditions and what was found could be attributed to cross‐talk with the masseter. The reflex responses obtained were significantly different between subjects; however retesting the same subject on a different occasion yielded similar results. The results indicate that the most common response of the masseter muscle to brisk axial stimulation of the incisor is a reflex inhibition at 20 ms, followed by a late excitation at 44 ms. However, it is possible that this late excitation could be due to delayed action potentials and hence be artefactual. As the application of a local anaesthetic block removed or significantly reduced both of these responses, it was concluded that they originated from the PMRs. Unlike during orthogonal stimulation, slowly rising stimuli did not produce any excitatory reflex activity. This indicated a difference in jaw reflexes to forces applied in different directions, possibly due to the activation of different receptor types when stimulating the tooth in either the orthogonal or axial directions.
Mitochondrial Network Genes in the Skeletal Muscle of Amyotrophic Lateral Sclerosis Patients

Recent evidence suggested that muscle degeneration might lead and/or contribute to neurodegeneration, thus it possibly play a key role in the etiopathogenesis and progression of amyotrophic lateral sclerosis (ALS). To test this hypothesis, this study attempted to categorize functionally relevant genes within the genome-wide expression profile of human ALS skeletal muscle, using microarray technology and gene regulatory network analysis. The correlation network structures significantly change between patients and controls, indicating an increased inter-gene connection in patients compared to controls. The gene network observed in the ALS group seems to reflect the perturbation of muscle homeostasis and metabolic balance occurring in affected individuals. In particular, the network observed in the ALS muscles includes genes (PRKR1A, FOXO1, TRIM32, ACTN3, among others), whose functions connect the sarcomere integrity to mitochondrial oxidative metabolism. Overall, the analytical approach used in this study offer the possibility to observe higher levels of correlation (i.e. common expression trends) among genes, whose function seems to be aberrantly activated during the progression of muscle atrophy.