Miracle-dz/UniFAR-FTUs huggingface dataset:
Genomewide Spatial Correspondence Between Nonsynonymous Divergence and Neutral Polymorphism Reveals Extensive Adaptation in Drosophila

The effect of recurrent selective sweeps is a spatially heterogeneous reduction in neutral polymorphism throughout the genome. The pattern of reduction depends on the selective advantage and recurrence rate of the sweeps. Because many adaptive substitutions responsible for these sweeps also contribute to nonsynonymous divergence, the spatial distribution of nonsynonymous divergence also reflects the distribution of adaptive substitutions. Thus, the spatial correspondence between neutral polymorphism and nonsynonymous divergence may be especially informative about the process of adaptation. Here we study this correspondence using genomewide polymorphism data from Drosophila simulans and the divergence between D. simulans and D. melanogaster. Focusing on highly recombining portions of the autosomes, at a spatial scale appropriate to the study of selective sweeps, we find that neutral polymorphism is both lower and, as measured by a new statistic QS, less homogeneous where nonsynonymous divergence is higher and that the spatial structure of this correlation is best explained by the action of strong recurrent selective sweeps. We introduce a method to infer, from the spatial correspondence between polymorphism and divergence, the rate and selective strength of adaptation. Our results independently confirm a high rate of adaptive substitution (∼1/3000 generations) and newly suggest that many adaptations are of surprisingly great selective effect (∼1%), reducing the effective population size by ∼15% even in highly recombining regions of the genome.
Truncation Confusion Patterns in Onset Consonants

Confusion matrices and truncation experiments have long been a part of psychoacoustic experimentation. However confusion matrices are seldom used to analyze truncation experiments. A truncation experiment was conducted and the confusion patterns were analyzed for 6 consonant-vowels (CVs). The confusion patterns show significant structure as the CV is truncated from the onset of the consonant. These confusions show correlations with both articulatory, acoustic features, and other related CVs. These confusions patterns are shown and explored as they relate to human speech recognition.
In the winning mood: Affect in the Iowa gambling task

The present research aimed to test the role of mood in the Iowa Gambling Task (IGT; Bechara et al., 1994). In the IGT, participants can win or lose money by picking cards from four different decks. They have to learn by experience that two decks are overall advantageous and two decks are overall disadvantageous. Previous studies have shown that at an early stage in this card-game, players begin to display a tendency towards the advantageous decks. Subsequent research suggested that at this stage, people base their decisions on conscious gut feelings (Wagar & Dixon, 2006). Based on empirical evidence for the relation between mood and cognitive processing-styles, we expected and consistently found that, compared to a negative mood state, reported and induced positive mood states increased this early tendency towards advantageous decks. Our results provide support for the idea that a positive mood causes stronger reliance on affective signals in decision-making than a negative mood.
Psychosocial outcomes of bone marrow transplant for individuals affected by MPS I Hurler Disease

RATIONALE: A theoretical model was used to examine the impact of risk and resistance factors on the psychosocial adjustment of children and young people affected by Mucopolysaccharidosis Type I Hurler Disease post-bone marrow transplant. METHOD: A sequential exploratory mixed methods design was employed and the study carried out in two phases. In the initial phase qualitative methods were employed in an in-depth study of a small sample of parents of individuals affected by this condition (n=10). They were administered semi-structured interviews, which were analysed using Interpretative Phenomenological Analysis. The themes highlighted were used to inform the design of the second phase, which employed quantitative methods. In this phase forty-four families affected by MPS IH post-BMT participated (44 mothers, 36 fathers, 44 patient participants). This comprised almost the entire population of this patient group in the UK, whose ages ranged from 16 months to 25 years. A face-to-face survey method was used with the mothers, telephone-survey with the fathers and psychometric testing of the patient participants. The measures included risk factors (e.g. physical, cognitive, and adaptive functioning), resistance factors (intrapersonal, stress processing, and socialecological), and adjustment for both parent and patient participants. RESULTS: Data from the qualitative phase revealed a number of themes, highlighting numerous issues pertinent to parents of children affected by this condition. These included perceptions of child vulnerability, uncertainty, perceptions of stress and sources of support, and feeling that others do not understand their situation. Data from the second phase illustrate how stress processing and social-ecological factors make significant contributions to parent adjustment. They also illustrate how intrapersonal, socialecological, and maternal stress processing factors contribute significantly to patient adjustment. A theoretical path of the determinants of patient psychosocial outcomes was created to illustrate these relationships. CONCLUSION: The findings are indicative of how resistance factors moderate the effects that disease- and disability-related risk factors have on parent and patient adjustment as predicted by the model. The dynamic interplay between disease-related risk factors and intrapersonal, socialecological, and stress processing factors are discussed in relation to parent and patient adjustment outcomes, as are the implications these relationships pose for patient and family support.
Peran Motivasi Spiritual Agamis terhadap Organizational Citizenship Behavior (OCB) dan Kinerja Dosen (Studi pada Dosen Universitas Haluoleo Kendari)

Abstract: This study is designed to test and prove empirically the role of religious spiritual motivation, both directly and indirectly, through organizational citizenship behavior (OCB) on lecturers’ performance. Specifically, the purpose of this study is to analyze and empirically explore the role of : (1) aqeedah motivation on organizational citizenship behaviour (OCB), (2) ebada motivation on organizational citizenship behavior (OCB), (3) mu’amalah motivation on organizational citizenship behavior, (4) aqeedah motivation on lecturers’ performance, (5) ebada motivation on lecturers’ performance, (6) mu’amalah motivation on lecturers’ performance, and (7) organizational citizenship behavior (OCB) on lecturers’ performance. The study is expected to enrich and expand the literature in management science, particularly in the area of human resource development motivation of employees and organizational behavior which will be useful for academics and practitioners. The population of this study are all lecturers in Haluoleo University of Kendari which spreads out at 8 faculties. The samples are 120 lectuers, chosen using proportional sampling technique, and the analysis of the data uses PLS (Partial Least Square). The main conclusion of this study is that the performance of lecturer may be better if the ebada spiritual motivation is increased, especially in the understanding of religious values to the concepts of work, behaviour and performance in a religious point of view. Keywords: aqeedah motivation, ebada motivation, mu’amalah motivation, Organizational Citizenship Behavior (OCB), lecturer performance
Analysis of single nucleotide polymorphisms of CRYGA and CRYGB genes in control population of western Indian origin

Aim: Polymorphisms in γ-crystallins (CRYG) can serve as markers for lens differentiation and eye disorders leading to cataract. Several investigators have reported the presence of sequence variations within crystallin genes, with or without apparent effects on the function of the proteins both in mice and humans. Delineation of these polymorphic sites may explain the differences observed in the susceptibility to cataract observed among various ethnic groups. An easier Restriction Fragment Length Polymorphism (RFLP)-based method has been used to detect the frequency of four single nucleotide polymorphisms (SNPs) in CRYGA/CRYGB genes in control subjects of western Indian origin. Materials and Methods: A total of 137 healthy volunteers from western India were studied. Examination was performed to exclude volunteers with any ocular defects. Polymerase chain reaction (PCR)-RFLP based method was developed for genotyping of G198A (Intron A), T196C (Exon 3) of CRYGA and T47C (Promoter), G449T (Exon 2) of CRYGB genes. Results: The exonic SNPs in CRYGA and CRYGB were found to have an allele frequency 0.03 and 1.00 for ancestral allele respectively, while frequency of non-coding SNP in CRYGA was 0.72. Allele frequency of T90C of CRYGB varied significantly (P = 0.02) among different age groups. An in-silico analysis reveals that this sequence variation in CRYGB promoter impacts the binding of two transcription factors, ACE2 (Member of CLB2 cluster) and Progesterone Receptor (PR) which may impact the expression of CRYGB gene. Conclusions: This study establishes baseline frequency data for four SNPs in CRYGA and CRYGB genes for future case control studies on the role of these SNPs in the genetic basis of cataract.
Handbook of Affect and Social Cognition

Contents: Preface. J.P. Forgas, Introduction: Affect and Social Cognition. Part I: The Relationship Between Affect and Cognition: Fundamental Issues. R. Adolphs, A.R. Damasio, The Interaction of Affect and Cognition: A Neurobiological Perspective. T.A. Ito, J.T. Cacioppo, Affect and Attitudes: A Social Neuroscience Approach. C.A. Smith, L.D. Kirby, Affect and Cognitive Appraisal Processes. Part II: Affective Influences on the Content of Cognition. G.H. Bower, J.P. Forgas, Mood and Social Memory. G.L. Clore, K. Gasper, E. Garvin, Affect as Information. C. Sedikides, J.D. Green, Affective Influences on the Self-Concept: Qualifying the Mood-Congruency Principle. Part III: Affective Influences on Social Information Processing. K. Fiedler, Affective Influences on Social Information Processing. E.T. Higgins, Promotion and Prevention Experiences: Relating Emotions to Nonemotional Motivational States. R.E. Petty, D. DeSteno, D.D. Rucker, The Role of Affect in Attitude Change. Part IV: Affective Influences on Motivation and Intentions. E. Harmon-Jones, The Role of Affect in Cognitive-Dissonance Processes. Y. Trope, M. Ferguson, R. Raghunathan, Mood as a Resource in Processing Self-Relevant Information. M.W. Erber, R. Erber, The Role of Motivated Social Cognition in the Regulation of Affective States. Part V: Affective Influences on Cognitively Mediated Social Behaviors. J.P. Forgas, Affect, Cognition, and Interpersonal Behavior: The Mediating Role of Processing Strategies. G.V. Bodenhausen, T. Mussweiler, S. Gabriel, K.N. Moreno, Affective Influences on Stereotyping and Intergroup Relations. P. Salovey, J.B. Detweiler, W.T. Steward, B.T. Bedell, Affect and Health-Relevant Cognition. Part VI: The Role of Individual Differences in Affectivity. C.L. Rusting, Personality as a Moderator of Affective Influences on Cognition. J. Suls, Affect, Stress, and Personality. J.D. Mayer, Emotion, Intelligence, and Emotional Intelligence.
Rumination and Loneliness Independently Predict Six-Month Later Depression Symptoms among Chinese Elderly in Nursing Homes

Background Previous studies conducted in Western countries independently demonstrated that loneliness and rumination are remarkable risk factors of depression among the elderly in both community and nursing homes. However, knowledge on the relationship between these three constructs among the elderly in Eastern countries is scarce. The current study aims to determine the relationship between loneliness, rumination, and depression among Chinese elderly in nursing homes. Methods A total of 71 elderly participants with an average age of 82.49 years completed this six-month longitudinal study. Physical reports indicated that none of the participants were clinically depressed before the study. At Time 1, their loneliness and rumination were measured using UCLA-8 Loneliness Scale and Ruminative Responses Scale. Six months later, the participants completed the Center for Epidemiologic Studies Depression Scale to assess depressive symptoms (Time 2). Results Multiple regression analysis revealed that both loneliness and rumination at Time 1 were the predictors of depression symptoms at Time 2 among the Chinese elderly in nursing homes. However, in the mediation analysis using PROCESS, the indirect effect between loneliness at Time 1 and depression symptoms at Time 2 was insignificant. Conclusions Results suggest that previous loneliness and rumination thinking are predictors of future depression symptoms among the Chinese elderly in nursing homes. However, the insignificant mediation further suggests that the differences between loneliness and rumination should be explored in future studies. Findings have important implications for mental health professionals in nursing homes in China.
Sparse Sensing and DMD-Based Identification of Flow Regimes and Bifurcations in Complex Flows

We present a sparse sensing framework based on dynamic mode decomposition (DMD) to identify flow regimes and bifurcations in large-scale thermofluid systems. Motivated by real-time sensing and control of thermal-fluid flows in buildings and equipment, we apply this method to a direct numerical simulation (DNS) data set of a two-dimensional laterally heated cavity. The resulting flow solutions can be divided into several regimes, ranging from steady to chaotic flow. The DMD modes and eigenvalues capture the main temporal and spatial scales in the dynamics belonging to different regimes. Our proposed classification method is data driven, robust w.r. t. measurement noise, and exploits the dynamics extracted from the DMD method. Namely, we construct an augmented DMD basis, with “built-in” dynamics, given by the DMD eigenvalues. This allows us to employ a short time series of data from sensors, to more robustly classify flow regimes, particularly in the presence of measurement noise. We also exploit the incoher.
Functional Analysis of Rpn6p, a Lid Component of the 26 S Proteasome, Using Temperature-sensitive rpn6 Mutants of the Yeast Saccharomyces cerevisiae*

Rpn6p is a component of the lid of the 26 S proteasome. We isolated and analyzed two temperature-sensitive rpn6 mutants in the yeast, Saccharomyces cerevisiae. Both mutants showed defects in protein degradation in vivo. However, the affinity-purified 26 S proteasome of the rpn6 mutants grown at the permissive temperature degraded polyubiquitinated Sic1p efficiently, even at a higher temperature. Interestingly, their enzyme activity was even higher at a higher temperature, indicating that once made mutant proteasomes are stable and have little defect in the proteolytic function. These results suggest that the deficiency in protein degradation observed in vivo is rather due to a defect in the assembly of a holoenzyme at the restrictive temperature. Indeed, both rpn6 mutants grown at the restrictive temperature were defective in assembling the 26 S proteasome. A striking feature of the rpn6 mutants at the restrictive temperature was that there appeared a protein complex composed of only four of the nine lid components, Rpn5p, Rpn8p, Rpn9p, and Rpn11p. Altogether, we conclude that Rpn6p is essential for the integrity/assembly of the lid in the sense that it is necessary for the incorporation of Rpn3p, Rpn7p, Rpn12p, and Sem1p (Rpn15p) into the lid, thereby playing an essential role in the proper function of the 26 S proteasome.
She Looks Sad, But He Looks Mad: The Effects of Age, Gender, and Ambiguity on Emotion Perception

ABSTRACT This study investigated how target sex, target age, and expressive ambiguity influence emotion perception. Undergraduate participants (N = 192) watched morphed video clips of eight child and eight adult facial expressions shifting from neutral to either sadness or anger. Participants were asked to stop the video clip when they first saw an emotion appear (perceptual sensitivity) and were asked to identify the emotion that they saw (accuracy). Results indicate that female participants identified sad expressions sooner in female targets than in male targets. Participants were also more accurate identifying angry facial expressions by male children than by female children. Findings are discussed in terms of the effects of ambiguity, gender, and age on the perception of emotional expressions.
Managing at the Speed of Change

panamabustickets.com Study has actually finished composing Managing At The Speed Of Change This is a most recent edition presented for you. Now, you can be read and downloaded Managing At The Speed Of Change in pdf, txt, rar, word, zip, ppt, as well as kindle. managing at the speed of change keith walker managing at the speed of change how resilient managers succeed and prosper where others fail daryl r. conner e x e c u t i v e b o o k s u m m a ry ? executives who suc-cessfully implement change, regardless of their location, display many of the same basic emotions, behaviors,
Why Price Stability

The European System of Central Banks (ESCB) is contractually obliged to ensure price stability. That is a vital prerequisite for the applicability of the nominalistic principle in a monetary economy according to which money debt consists merely of a certain quantity of accounting units like a number of dollars or euros. The conceptual pair of the nominalistic principle and price stability is seen as plausible focal principle (Schelling) of transaction cost minimizing actors of a paper money economy. On the other hand, an inflationary target of x% as suggested by Bernanke et al. contradicts not only the nominalistic principle that actually underlies the German legal system but, on its own, is also implausible as focal principle.
Understanding stress and burnout in birth suitemidwives

Perhaps due to the perception of midwifery being an inherently pleasurable pursuit, there has been limited research of the stress and burnout midwives may experience. However, with evident difficulties in recruiting and retaining midwives, this is an area that requires research. Therefore the stress and burnout experienced by midwives who work in birthing suite was explored in terms of their coping style and levels of social support and assessed in terms of the levels of stress, burnout and compassion fatigue experienced.
Partially Functional Outer-Arm Dynein in a Novel Chlamydomonas Mutant Expressing a Truncated γ Heavy Chain

ABSTRACT The outer dynein arm of Chlamydomonas flagella contains three heavy chains (α, β, and γ), each of which exhibits motor activity. How they assemble and cooperate is of considerable interest. Here we report the isolation of a novel mutant, oda2-t, whose γ heavy chain is truncated at about 30% of the sequence. While the previously isolated γ chain mutant oda2 lacks the entire outer arm, oda2-t retains outer arms that contain α and β heavy chains, suggesting that the N-terminal sequence (corresponding to the tail region) is necessary and sufficient for stable outer-arm assembly. Thin-section electron microscopy and image analysis localize the γ heavy chain to a basal region of the outer-arm image in the axonemal cross section. The motility of oda2-t is lower than that of the wild type and oda11 (lacking the α heavy chain) but higher than that of oda2 and oda4-s7 (lacking the motor domain of the β heavy chain). Thus, the outer-arm dynein lacking the γ heavy-chain motor domain is partially functional. The availability of mutants lacking individual heavy chains should greatly facilitate studies on the structure and function of the outer-arm dynein.
DNA Repair Polymorphisms Modify Bladder Cancer Risk: A Multi-factor Analytic Strategy

Objectives: A number of common non-synonymous single nucleotide polymorphisms (SNPs) in DNA repair genes have been reported to modify bladder cancer risk. These include: APE1-Asn148Gln, XRCC1-Arg399Gln and XRCC1-Arg194Trp in the BER pathway, XPD-Gln751Lys in the NER pathway and XRCC3-Thr241Met in the DSB repair pathway. Methods: To examine the independent and interacting effects of these SNPs in a large study group, we analyzed these genotypes in 1,029 cases and 1,281 controls enrolled in two case-control studies of incident bladder cancer, one conducted in New Hampshire, USA and the other in Turin, Italy. Results: The odds ratio among current smokers with the variant XRCC3-241 (TT) genotype was 1.7 (95% CI 1.0–2.7) compared to wild-type. We evaluated gene-environment and gene-gene interactions using four analytic approaches: logistic regression, Multifactor Dimensionality Reduction (MDR), hierarchical interaction graphs, classification and regression trees (CART), and logic regression analyses. All five methods supported a gene-gene interaction between XRCC1-399/XRCC3-241 (p = 0.001) (adjusted OR for XRCC1-399 GG, XRCC3-241 TT vs. wild-type 2.0 (95% CI 1.4–3.0)). Three methods predicted an interaction between XRCC1-399/XPD-751 (p = 0.008) (adjusted OR for XRCC1-399 GA or AA, XRCC3-241 AA vs. wild-type 1.4 (95% CI 1.1–2.0)). Conclusions: These results support the hypothesis that common polymorphisms in DNA repair genes modify bladder cancer risk and highlight the value of using multiple complementary analytic approaches to identify multi-factor interactions.
Children with Visual Impairments: Social Interaction, Language and Learning

This book is aimed at the mainstream class teacher who has little or no experience of providing effective learning experiences for children with visual impairments. It is designed both as an introductory guide to assessment and provision. It also has a strong focus on social interactions, since many teachers are confused as how to help children with visual impairments make friends. The book sets out the basis for addressing the individual with a wide range of visual impairments. Chapters cover: the identification and assessment of aspects of vision visual impairment and individual needs practical advice on the development of concepts, language and literacy and social skills the use of low vision aids, appropriate decor and physical layouts, lighting and IT educational policy and the Code of Practice Drawing on very recent research, this book presents new insights into the needs of children with visual impairments as learners, arguing that it is the quality of the child's social interactions which promotes play, language and learning.