Miracle-dz/UniFAR-FTUs huggingface dataset:
Laser surgery of port wine stains using local vaccum pressure: Changes in calculated energy deposition (Part II)

Application of local vacuum pressure to human skin during laser irradiation results in less absorption in the epidermis and more light delivered to targeted vessels with an increased blood volume. The objective of the present numerical study is to assess the effect of applying local vacuum pressure on the temperatures of the epidermis and small vessels during port wine stain (PWS) laser treatment.
Intraventricular Early Diastolic Filling During Acute Myocardial Ischemia Assessment by Multigated Color M‐Mode Doppler Echocardiography

BackgroundColor M-mode Doppler echocardiography has been suggested as a new noninvasive technique for assessing left ventricular diastolic function. The present study investigated intraventricular filling pattern by color M-mode Doppler in patients during percutaneous transluminal coronary angioplasty (PTCA). In a dog model of myocardial ischemia, the color M-mode flow pattern was related to indices of global and regional myocardial function. Methods and ResultsFrom color M-mode images, the time difference (TD) between occurrence of peak velocity in the apical region and at the mitral tip was determined in 20 patients and eight anesthetized dogs during coronary occlusions. During PTCA, the timing of peak velocity was progressively delayed from mitral valve to apex. Consistent with this, the dog model showed delayed apical filling during coronary occlusion; TD increased from 18±4 to 71±9 milliseconds (P<.01). In the ischemic region, systolic shortening (sonomicrometry) decreased from 20±3% to -5±2% (P<.01). The one-third filling fraction decreased from 59±5% to 31±6% (P<.01) and correlated with TD (r=.85, p>.01). The time constant of isovolumic relaxation (T) increased slightly and correlated with TD (r=.81, p>.01). Pacing tachycardia, caval constriction, and volume loading were performed to mimic the ischemia-induced changes in heart rate, stroke volume, and intracavitary filling pressure, respectively. There were no significant changes in TD or during these interventions. ConclusionsColor M-mode Doppler echocardiography showed a marked delay of apical peak filling velocity during PTCA. The experimental data suggest that this reflects retarded filling of the ischemic ventricle. Thus, color M-mode Doppler may provide a useful method for assessing diastolic dysfunction.
Evolution of flowering strategies in Oenothera glazioviana: an integral projection model approach

The timing of reproduction is a key determinant of fitness. Here, we develop parameterized integral projection models of size–related flowering for the monocarpic perennial Oenothera glazioviana and use these to predict the evolutionarily stable strategy (ESS) for flowering. For the most part there is excellent agreement between the model predictions and the results of quantitative field studies. However, the model predicts a much steeper relationship between plant size and the probability of flowering than observed in the field, indicating selection for a ‘threshold siz’ flowering function. Elasticity and sensitivity analysis of population growth rate λ and net reproductive rate R0 are used to identify the critical traits that determine fitness and control the ESS for flowering. Using the fitted model we calculate the fitness landscape for invading genotypes and show that this is characterized by a ridge of approximately equal fitness. The implications of these results for the maintenance of genetic variation are discussed.
Skeleton-Based Edge Bundling for Graph Visualization

In this paper, we present a novel approach for constructing bundled layouts of general graphs. As layout cues for bundles, we use medial axes, or skeletons, of edges which are similar in terms of position information. We combine edge clustering, distance fields, and 2D skeletonization to construct progressively bundled layouts for general graphs by iteratively attracting edges towards the centerlines of level sets of their distance fields. Apart from clustering, our entire pipeline is image-based with an efficient implementation in graphics hardware. Besides speed and implementation simplicity, our method allows explicit control of the emphasis on structure of the bundled layout, i.e. the creation of strongly branching (organic-like) or smooth bundles. We demonstrate our method on several large real-world graphs.
NSAIDs Modulate Clonal Evolution in Barrett's Esophagus

Cancer is considered an outcome of decades-long clonal evolution fueled by acquisition of somatic genomic abnormalities (SGAs). Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce cancer risk, including risk of progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EA). However, the cancer chemopreventive mechanisms of NSAIDs are not fully understood. We hypothesized that NSAIDs modulate clonal evolution by reducing SGA acquisition rate. We evaluated thirteen individuals with BE. Eleven had not used NSAIDs for 6.2±3.5 (mean±standard deviation) years and then began using NSAIDs for 5.6±2.7 years, whereas two had used NSAIDs for 3.3±1.4 years and then discontinued use for 7.9±0.7 years. 161 BE biopsies, collected at 5–8 time points over 6.4–19 years, were analyzed using 1Million-SNP arrays to detect SGAs. Even in the earliest biopsies there were many SGAs (284±246 in 10/13 and 1442±560 in 3/13 individuals) and in most individuals the number of SGAs changed little over time, with both increases and decreases in SGAs detected. The estimated SGA rate was 7.8 per genome per year (95% support interval [SI], 7.1–8.6) off-NSAIDs and 0.6 (95% SI 0.3–1.5) on-NSAIDs. Twelve individuals did not progress to EA. In ten we detected 279±86 SGAs affecting 53±30 Mb of the genome per biopsy per time point and in two we detected 1,463±375 SGAs affecting 180±100 Mb. In one individual who progressed to EA we detected a clone having 2,291±78 SGAs affecting 588±18 Mb of the genome at three time points in the last three of 11.4 years of follow-up. NSAIDs were associated with reduced rate of acquisition of SGAs in eleven of thirteen individuals. Barrett's cells maintained relative equilibrium level of SGAs over time with occasional punctuations by expansion of clones having massive amount of SGAs.
A Wizard of Oz study for an AR multimodal interface

In this paper we describe a Wizard of Oz (WOz) user study of an Augmented Reality (AR) interface that uses multimodal input (MMI) with natural hand interaction and speech commands. Our goal is to use a WOz study to help guide the creation of a multimodal AR interface which is most natural to the user. In this study we used three virtual object arranging tasks with two different display types (a head mounted display, and a desktop monitor) to see how users used multimodal commands, and how different AR display conditions affect those commands. The results provided valuable insights into how people naturally interact in a multimodal AR scene assembly task. For example, we discovered the optimal time frame for fusing speech and gesture commands into a single command. We also found that display type did not produce a significant difference in the type of commands used. Using these results, we present design recommendations for multimodal interaction in AR environments.
Extreme Nonlinear Correlation for Multiple Random Variables and Stochastic Processes with Applications to Additive Models

The maximum correlation of functions of a pair of random variables is an important measure of stochastic dependence. It is known that this maximum nonlinear correlation is identical to the absolute value of the Pearson correlation for a pair of Gaussian random variables or a pair of nested sums of iid square integrable random variables. This paper extends these results to pairwise Gaussian processes and vectors, nested sums of iid random variables, and permutation symmetric functions of sub-groups of iid random variables.
Towards Generalizable Sentence Embeddings

In this work, we evaluate different sentence encoders with emphasis on examining their embedding spaces. Speciﬁ-cally, we hypothesize that a “high-quality” embedding aids in generalization, promoting transfer learning as well as zero-shot and one-shot learning. To investigate this, we modify Skipthought vectors to learn a more generalizable space by exploiting a small amount of supervision. The aim is to introduce an additional notion of similarity in the embeddings, rendering the vectors informative for different tasks requiring less adaptation. Our embeddings capture human intuition on similarity favorably than competing models, while we also show positive indications of transfer from the task of natural language inference to paraphrase detection and paraphrase ranking. Further, our model’s behaviour on paraphrase detection when trained with an increasing amount of labelled data is indicative of a generalizable model. Finally, we support our hypothesis on generalizability of our embeddings through inspection of their statistics.
Managers' email: beyond tasks and to-dos

In this paper, we describe preliminary findings that indicate that managers and non-mangers think about their email differently. We asked three research managers and three research non-managers to sort about 250 of their own email messages into categories that "would help them to manage their work. " Our analyses indicate that managers create more categories and a more differentiated category structure than non-managers. Our data also suggest that managers create "relationship-oriented" categories more often than non-managers. These results are relevant to research on "email overload" that has highlighted the use of email for activities beyond communication. In particular, our findings suggest that too strong a focus on task management may be incomplete, and that a user's organizational role has an impact on their conceptualization and likely use of email.
Rethinking Language, Mind and World Dialogically : Interactional and contextual theories of human sense-making

A volume in Advances in Cultural PsychologySeries Editor: Jaan Valsiner, Clark University"This is a remarkable and highly original work on dialogism, dialogical theories and dialogue. With his erudite and broadly based scholarship PerLinell makes a path-breaking contribution to the study of the human mind, presenting a novel alternative to traditional monologism and exploring thedynamics of sense-making in different forms of interaction and communicative projects. Although Per Linell discusses complex dialogical concepts, the text is written with exceptional clarity, taking the reader through critique as well as appreciation of great intellectual traditions of our time. "(Professor Ivana Markov, University of Stirling, U.K.)"Per Linells Rethinking Language, Mind And World Dialogically represents a landmark in the development ofa transdisciplinary dialogically basedparadigm for the human sciences. The author? 's lucid analysis and constructive rethinking ranges all the way from integrating explanations ofsignificant empirical contributions across the entire range of human sciences dealing with language, thought and communication to foundational, epistemological and ontological issues. "(Professor Ragnar Rommetveit, University of Oslo, Norway)Per Linell took his degree in linguistics and is currently professor of language and culture, with a specialisation on communication and spokeninteraction, at the University of Link ping, Sweden. He has been instrumental in building up an internationally renowned interdisciplinary graduateschool in communication studies in Link ping. He has worked for many years on developing a dialogical alternative to mainstream theories inlinguistics, psychology and social sciences. His production comprises more than 100 articles on dialogue, talk-in-interaction and institutionaldiscourse. His more recent books include Approaching Dialogue (1998), The Written Language Bias in Linguistics (2005) and Dialogue in FocusGroups (2007, with I. Markov, M. Grossen and A. Salazar Orvig).
Recruitment of the default mode network during a demanding act of executive control

In the human brain, a default mode or task-negative network shows reduced activity during many cognitive tasks and is often associated with internally-directed processes, such as mind wandering and thoughts about the self. In contrast to this task-negative pattern, we show increased activity during a large and demanding switch in task set. Furthermore, we employ multivoxel pattern analysis and find that regions of interest within default mode network are encoding task-relevant information during task performance. Activity in this network may be driven by major revisions of cognitive context, whether internally or externally focused. DOI: http://dx.doi. org/10.7554/eLife.06481. 001
Is Gamma-Band Activity in the Local Field Potential of V1 Cortex a “Clock” or Filtered Noise?

Gamma-band (25–90 Hz) peaks in local field potential (LFP) power spectra are present throughout the cerebral cortex and have been related to perception, attention, memory, and disorders (e.g., schizophrenia and autism). It has been theorized that gamma oscillations provide a “clock” for precise temporal encoding and “binding” of signals about stimulus features across brain regions. For gamma to function as a clock, it must be autocoherent: phase and frequency conserved over a period of time. We computed phase and frequency trajectories of gamma-band bursts, using time-frequency analysis of LFPs recorded in macaque primary visual cortex (V1) during visual stimulation. The data were compared with simulations of random networks and clock signals in noise. Gamma-band bursts in LFP data were statistically indistinguishable from those found in filtered broadband noise. Therefore, V1 LFP data did not contain clock-like gamma-band signals. We consider possible functions for stochastic gamma-band activity, such as a synchronizing pulse signal.
Pharmacokinetic interactions between chloroquine, sulfadoxine and pyrimethamine and their bioequivalence in a generic fixed-dose combination in healthy volunteers in Uganda.

BACKGROUND A pre-packaged fixed-dose formulation of chloroquine (CQ) and sulfadoxine/pyrimethamine (S/P) combination (Homapak) is widely used for the treatment of falciparum malaria in Ugandan children. It is however a product whose pharmacokinetics and interactions have not been studied. OBJECTIVES To explore possible pharmacokinetic interactions between CQ and S/P during co-administration, and to determine their bioavailability in the locally made Homapak compared to the Good Manufacturing Practice (GMP) made formulations. METHODS Thirty-two adult healthy volunteers were randomized into four groups and given single oral doses of fixed-dose CQ+S/P combination (Homapak), or GMP formulations of S/P (Fansidar), CQ (Pharco), or their combination. Plasma samples were followed for 21 days, analysed by HPLC-UV methods, with pharmacokinetic modeling using the WinNonlin software. RESULTS Sulfadoxine in Homapak was more rapidly absorbed (ka = 0.55 h(-1)) than in Fansidar + CQ (ka = 0.27 h(-1), p=0.004), but not more than S in Fansidar alone group (ka = 0.32 h(-1), p=0.03). No significant differences were observed in the other pharmacokinetic parameters of S, P and CQ when given together or separately. The relative bioavailability of CQ and S in Homapak showed bioequivalence to reference formulations. CONCLUSIONS There were no pharmacokinetic interactions between CQ, S and P when the compounds were given together, however, more investigations would be needed to explore this further. Compared with GMP made drugs, both S and CQ are bioequivalent in Homapak, the Ugandan made fixed-dose formulation. Furthermore, the absorption of S was more rapid which could be advantageous in malaria treatment.
Fatal thyrocardiac event

Atrial fibrillation occurs frequently (2–20%) in chronic hyperthyroidism patients. Poorly treated thyrotoxic patients may present with a life-threatening cerebrovascular accident giving little scope to revert the situation. At times, it is difficult to make a patient euthyroid with conventional management. The definitive treatment of choice is 131I, radioiodine. An adjusted dose of an oral anticoagulant is highly efficacious for the prevention of all types of strokes. Timely intervention by a skilled airway manager with right instruments is the key to success in airway management. A 50-year-old thyrotoxic, semiconscious male presented with a sudden onset of haemiplegia. He had chronic AF, a huge thyroid swelling with gross tracheal deviation and dilated cardiomyopathy. A CT scan showed infarction in the left middle cerebral artery territory. After initial improvement with conservative management, patient’s condition deteriorated in the next 48 h. Repeat CT scan showed increase in the infarct size with haemorrhage and midline shift. Finally, he died despite all resuscitative measures.
Identification of GATA6 Sequence Variants in Patients With Congenital Heart Defects

Although the etiology for the majority of congenital heart disease (CHD) remains poorly understood, the known genetic causes are often the result of mutations in cardiac developmental genes. GATA6 encodes for a cardiac transcription factor, which is broadly expressed in the developing heart and is critical for normal cardiac morphogenesis, making it a candidate gene for congenital heart defects in humans. The objective of this study was to determine the frequency of GATA6 sequence variants in a population of individuals with a spectrum of cardiac malformations. The coding regions of GATA6 were sequenced in 310 individuals with CHD. We identified two novel sequence variations in GATA6 that altered highly conserved amino acid residues (A178V and L198V) and were not found in a control population. These variants were identified in two individuals (one with tetralogy of Fallot and the other with an atrioventricular septal defect in the setting of complex CHD). Biochemical studies demonstrate that the GATA6 A178V mutant protein results in increased transactivation ability when compared with wild-type GATA6. These data suggest that nonsynonymous GATA6 sequence variants are infrequently found in individuals with CHD.
Interaction of Calcium-dependent Activator Protein for Secretion 1 (CAPS1) with the Class II ADP-ribosylation Factor Small GTPases Is Required for Dense-core Vesicle Trafficking in the trans-Golgi Network*

Ca2+-dependent activator protein for secretion (CAPS) regulates exocytosis of catecholamine- or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites, such as nerve terminals. However, large amounts of CAPS protein are localized in the cell soma, and the role of somal CAPS protein remains unclear. The present study shows that somal CAPS1 plays an important role in DCV trafficking in the trans-Golgi network. The anti-CAPS1 antibody appeared to pull down membrane fractions, including many Golgi-associated proteins, such as ADP-ribosylation factor (ARF) small GTPases. Biochemical analyses of the protein-protein interaction showed that CAPS1 interacted specifically with the class II ARF4/ARF5, but not with other classes of ARFs, via the pleckstrin homology domain in a GDP-bound ARF form-specific manner. The pleckstrin homology domain of CAPS1 showed high affinity for the Golgi membrane, thereby recruiting ARF4/ARF5 to the Golgi complex. Knockdown of either CAPS1 or ARF4/ARF5 expression caused accumulation of chromogranin, a DCV marker protein, in the Golgi, thereby reducing its DCV secretion. In addition, the overexpression of CAPS1 binding-deficient ARF5 mutants induced aberrant chromogranin accumulation in the Golgi and consequently reduced its DCV secretion. These findings implicate a functional role for CAPS1 protein in the soma, a major subcellular localization site of CAPS1 in many cell types, in regulating DCV trafficking in the trans-Golgi network; this activity occurs via protein-protein interaction with ARF4/ARF5 in a GDP-dependent manner.
Cooperative relay techniques for cognitive radio systems: Spectrum sensing and secondary user transmissions

Cognitive radio is a promising technology that enables an unlicensed user (also known as a cognitive user) to identify the white space of a licensed spectrum band (called a spectrum hole) and utilize the detected spectrum hole for its data transmissions. To design a reliable and efficient cognitive radio system, there are two fundamental issues: to devise an accurate and robust spectrum sensing algorithm to detect spectrum holes as accurately as possible; and to design a secondary user transmission mechanism for the cognitive user to utilize the detected spectrum holes as efficiently as possible. This article investigates and shows that cooperative relay technology can significantly benefit the abovementioned two issues, spectrum sensing and secondary transmissions. We summarize existing research about the application of cooperative relays for spectrum sensing (referred to as the cooperative sensing) and address the related potential challenges. We discuss the use of cooperative relays for the secondary transmissions with a primary user's quality-of-service (QoS) constraint, for which a diversity-multiplexing trade-off is developed. In addition, this article shows a trade-off design of cognitive transmissions with cooperative relays by jointly considering the spectrum sensing and secondary transmissions in cognitive radio networks.
Ultrastructural Analysis of Virion Formation and Intraaxonal Transport of Herpes Simplex Virus Type 1 in Primary Rat Neurons

ABSTRACT After primary replication at the site of entry into the host, alphaherpesviruses infect and establish latency in neurons. To this end, they are transported within axons retrograde from the periphery to the cell body for replication and in an anterograde direction to synapses for infection of higher-order neurons or back to the periphery. Retrograde transport of incoming nucleocapsids is well documented. In contrast, there is still significant controversy on the mode of anterograde transport. By high-resolution transmission electron microscopy of primary neuronal cultures from embryonic rat superior cervical ganglia infected by pseudorabies virus (PrV), we observed the presence of enveloped virions in axons within vesicles supporting the “married model” of anterograde transport of complete virus particles within vesicles (C. Maresch, H. Granzow, A. Negatsch, B.G. Klupp, W. Fuchs, J.P. Teifke, and T.C. Mettenleiter, J. Virol. 84:5528-5539, 2010). We have now extended these analyses to the related human herpes simplex virus type 1 (HSV-1). We have demonstrated that in neurons infected by HSV-1 strains HFEM, 17+ or SC16, approximately 75% of virus particles observed intraaxonally or in growth cones late after infection constitute enveloped virions within vesicles, whereas approximately 25% present as naked capsids. In general, the number of HSV-1 particles in the axons was significantly less than that observed after PrV infection.