Miracle-dz/UniFAR-FTUs huggingface dataset:
Corruption in Committees: An Experimental Study of Information Aggregation through Voting

We investigate experimentally the effects of corrupt experts on information aggregation in committees. We find that nonexperts are significantly less likely to delegate through abstention when there is a probability that experts are corrupt. Such decreased abstention, when the probability of corrupt experts is low, actually increases information efficiency in committee decision-making. However, if the probability of corrupt experts is large, the effect is not sufficient to offset the mechanical effect of decreased information efficiency due to corrupt experts. Our results demonstrate that the norm of “letting the expert decide” in committee voting is influenced by the probability of corrupt experts, and that influence can have, to a limited extent, a positive effect on information efficiency.
Nonlinear interference noise in fibre-optic communications

We review the modelling of nonlinear interference in wavelength division multiplexed (WDM) fibre-optic systems. In particular, we focus on the analysis of inter-channel nonlinear interference noise, to which we refer as NLIN. We discuss the derivation of the variance and elaborate on the properties of NLIN in terms of its temporal correlations, the extent to which it manifests itself as nonlinear phase-noise, its dependence on modulation format, etc.
The Competitive Effects of Vertical Agreements: Comment

In a recent paper, Comanor and Frech (1985, "CF") claim that a manufacturer enjoying a product differentiation advantage could impose exclusive dealing on distributors while also raising its wholesale price. The two consumer groups in the model would then pay higher prices than under nonexclusive dealing. CF also suggest that exclusive dealing is more likely to emerge when product differentiation is relatively strong. CF's analysis does not carefully incorporate the constraints imposed by dealer rationality. Doing so within CF's model, I reach opposite conclusions. Exclusive dealing will be accepted only if the manufacturer reduces its wholesale price to dealers. Relative to nonexclusive dealing, price rises to one group of consumers but falls to the other. Moreover, exclusive dealing is more likely to emerge when product differentiation is relatively weak.
Partisanship, political constraints, and employment protection reforms in an era of austerity

Why do some governments adopt unpopular reforms entailing far-reaching liberalization of the labor market, while others opt only for marginal adjustments or even regulatory reforms? This paper explains the likelihood of different types of reforms as an effect of different constellations of government partisanship and veto players. Combining the ‘blame avoidance’ and ‘veto players’ logics of politics, I argue that veto players have either a constraining or enabling effect depending on the partisan orientation of government. Liberalization is most likely to be adopted either by right parties facing few veto players, or by left parties in contexts with a high degree of power sharing. Regulatory reforms are most likely when left governments enjoy strong power concentration, but marginal regulation may also be adopted under external pressure by right governments facing many veto players. An analysis of employment protection reforms in 24 European Union countries during 1990–2007 supports the argument that the effect of political constraints and opportunities on the choice of reforms is shaped by partisan differences.
Tripartite Mechanism of Extinction Suggested by Dopamine Neuron Activity and Temporal Difference Model

Extinction of behavior enables adaptation to a changing world and is crucial for recovery from disorders such as phobias and drug addiction. However, the brain mechanisms underlying behavioral extinction remain poorly understood. Midbrain dopamine (DA) neurons appear to play a central role in most acquisition processes of appetitive conditioning. Here, we show that the responses of putative DA neurons to conditioned reward predicting cues also dynamically encode two classical features of extinction: decrement in amplitude of previously learned excitatory responses and rebound of responding on subsequent retesting (spontaneous recovery). Crucially, this encoding involves development of inhibitory responses in the DA neurons, reflecting new, extinction-specific learning in the brain. We explored the implications of this finding by adding such inhibitory inputs to a standard temporal difference model of DA cell activity. We found that combining extinction-triggered plasticity of these inputs with a time-dependent spontaneous decay of weights, equivalent to a forgetting process as described in classical behavioral extinction literature, enabled the model to simulate several classical features of extinction. A key requirement to achieving spontaneous recovery was differential rates of spontaneous decay for weights representing original conditioning and for subsequent extinction learning. A testable prediction of the model is thus that differential decay properties exist within the wider circuits regulating DA cell activity. These findings are consistent with the hypothesis that extinction processes at both cellular and behavioral levels involve a dynamic interaction between new (inhibitory) learning, forgetting, and unlearning.
Toxico-Neurological Effects of Piroxicam in Monogastric Animals

Piroxicam is a benzothiazine compound with anti-inflammatory, antipyretic, and analgesic properties. Because of the very high efficacy of piroxicam and its increasing use in the treatment of carcinomas in dogs and cats, there is a need for acute toxicity study of piroxicam in monogastric animals and its potential for causing secondary poisoning in puppies. Piroxicam manufactured by Shanxi Federal Pharmaceutical Co, Ltd. was used for this study. Revised up-and-down procedure was used for the estimation of median lethal dose in mouse (259.4 ± 51.9 mg/kg), rat (259.4 ± 69.6 mg/kg), rabbit (707.5 ± 130.8 mg/kg), cat (437.5 ± 128.1 mg/kg), guinea pig (218.7 ± 64.1 mg/kg), monkey (733.3 ± 83.3 mg/kg), broiler (285.3 ± 62.5 mg/kg), hen (638.3 ± 115.4 mg/kg), turkey (707.5 ± 130.8 mg/kg), pigeon (375 ± 55.9 mg/kg), and duck (311.3 ± 46.6 mg/kg). The acute toxicity signs of piroxicam at doses 207.5 mg/kg and above observed in the animals are torticollis, opisthotonos, somnolence, lethargy, diarrhea, gastroenteritis, generalized internal bleeding, anemia, congestion of the lung and liver, flaccid paralysis, cheesy lung, urinary incontinence, engorged urinary bladder, convulsive jerking of the limbs, lying in ventral recumbency, gasping for air, roaring, and death. Three out of six puppies died after being fed the carcasses of poisoned turkey, duck, and hen administered piroxicam at doses of 1000, 415, and 1000 mg/kg, respectively. White flaky cheesy materials observed in turkeys were also observed in the gastrointestinal content of the puppies. Paleness of carcasses, watery crop content, dryness of pericardium, gastroenteritis, intestinal perforation, and whitish pericardium were observed in broilers. There were effusions in thoracic and abdominal cavities as seen in all other carcasses poisoned primarily by piroxicam. Administration of atropine (0.02 mg/kg) led to survival of the remaining puppies. In conclusion, piroxicam is very to moderately toxic in monogastric animals.
Upgrading Relay Protection: Be Prepared for the Next Replacement or Upgrade Project

There are many advantages to upgrading old electromechanical (EM), solid-state, and first-generation numeric relays with modern numeric relays. Reliability increases because there is less direct wiring and interconnection wiring, and the reliability and security of multifunction logic and settings are improved with the next-generation user interface software. Remote input-output modules, remote analog/digital inputs, and thermal measurement capabilities have expanded protection, control, and monitoring. New protection and monitoring features improve power system equipment life and increase personnel safety. Maintenance costs are reduced, while internal watchdogs alert the user if the relay has a problem. Settings groups can be changed instantaneously to adapt to varying power-system requirements. Modern second-generation numeric relays offer a variety of secure communications capabilities for interfacing with smart-grid controls, supervisory control and data-acquisition systems, and business networks. Event memory is larger for more onboard, standardized oscillographs and event reporting. Relay security is in accord with the latest North American Electric Reliability Corporation (NERC) standards.
Impact of sociodemographic factors on cognitive function in school-aged HIV-infected Nigerian children

Background In this study, we sought to evaluate the influence of sociodemographic factors, ie, age, sex, socioeconomic status, maternal education, and human immunodeficiency virus (HIV) status, on cognitive performance in school-aged HIV-infected Nigerian children. Methods Sixty-nine HIV-positive children aged 6–15 years were matched with 69 HIV-negative control children for age and sex. The children were subdivided for the purpose of analysis into two cognitive developmental stages using Piaget’s staging, ie, the concrete operational stage (6–11 years) and the formal operational stage (12–15 years). All participants underwent cognitive assessment using Raven’s Standard Progressive Matrices (RPM). Sociodemographic data for the study participants, ie, age, sex, socioeconomic status, and level of maternal education, were obtained using a study proforma. Logistic regression analyses were used to determine associations of HIV status and sociodemographic characteristics with RPM cognitive scores. Results The overall mean RPM score for the HIV-positive children was 18.2 ± 9.8 (range 8.0–47.0) which was significantly lower than the score of 27.2 ± 13.8 (range 8.0–52.0) for the HIV-negative children (P < 0.001). On RPM grading, 56.5% of the HIV-positive children had cognitive performance at below average to intellectually defective range. Below average RPM scores were found to be significantly associated with younger age (6–11 years), positive HIV status, lower socioeconomic status, and low level of maternal education. Conclusion Younger age, poor socioeconomic status, and low level of maternal education were factors apart from HIV infection that were significantly associated with low cognitive function in school-aged HIV-infected Nigerian children.
Isolation and Identification of ER Associated Proteins with Unique ExpressionChanges Specific to the V144D SPTLC1 Mutations in HSN-I

Axonal degeneration is the final common path in many neurological disorders. Hereditary sensory neuropathies (HSN) are a group of neuropathies involving the sensory neurons. The most common subtype is autosomal dominant hereditary sensory neuropathy type I (HSN-I). Progressive degeneration of the dorsal root ganglion (DRG) neuron with an onset of clinical symptoms between the second or third decade of life characterises HSN-I. Mutations in the serine palmitoyltransferase (SPT) long chain subunit 1 (SPTLC1) gene cause HSN-I. The endoplasmic reticulum (ER) is a dynamic organelle that houses the SPTLC1 protein. Ultra structural analysis has shown the ER in the HSN-I mutant cells to wrap around dysfunctional mitochondria and tethers them to the perinucleus. This investigation establishes that the V144D mutant of SPTLC1 alters the expression of and potentially interacts with a set of proteins within the ER. Using ER protein lysates from HSN-I patient and control lymphoblasts: we have identified a change in regulation of five proteins; Hypoxia Up regulated Protein 1: Chloride intracellular channel protein 1: Ubiqutin-40s Ribosomal protein S27a: Coactosin and Ig Kappa chain C. The expression and regulation of these proteins may help to establish a link between the ER and the ‘dying back’ process of the DRG neuron.
Security-aware optimal resource allocation for virtual network embedding

Network virtualization enables the creation of multiple instances of virtual networks on top of a single physical infrastructure. Given its wide applicability, this technique has attracted a lot of interest both from academic researchers and major companies within the segment of computer networks. Although recent efforts (motivated mainly by the search for mechanisms to evaluate Future Internet proposals) have contributed substantially to materialize this concept, none of them has attempted to combine efficient resource allocation with fulfillment of security requirements (e.g., confidentiality). It is important to note that, in the context of virtual networks, the protection of shared network infrastructures constitutes a fundamental condition to enable its use in large scale. To address this problem, in this paper we propose a virtual network embedding model that satisfies security requirements and, at the same time, optimizes physical resource usage. The results obtained demonstrate that the model is able to correctly and optimally map virtual networks to a physical substrate, minimizing bandwidth costs for infrastructure providers.
Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence

Low vitamin D status has been implicated in the etiology of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, insulin-dependent diabetes mellitus, and inflammatory bowel disease. The optimal level of vitamin D intake required to support optimal immune function is not known but is likely to be at least that required for healthy bones. Experimentally, vitamin D deficiency results in the increased incidence of autoimmune disease. Mechanistically, the data point to a role for vitamin D in the development of self-tolerance. The vitamin D hormone (1,25-dihydroxy vitamin D3) regulates T helper cell (Th1) and dendritic cell function while inducing regulatory T-cell function. The net result is a decrease in the Th1-driven autoimmune response and decreased severity of symptoms. This review discusses the accumulating evidence pointing to a link between vitamin D and autoimmunity. Increased vitamin D intakes might decrease the incidence and severity of autoimmune diseases and the rate of bone fracture.
Financial Liberalisation, Bureaucratic Corruption and Economic

We study the effect of international financial integration on economic development when the quality of governance may be compromised by corruption. Our analysis is based on a dynamic general equilibrium model of a small economy in which growth is driven by capital accumulation and public policy is administered by government- appointed bureaucrats. Corruption may arise due to the opportunity for bureaucrats to embezzle public funds, an opportunity that is made more attractive by financial liberalisation which, at the same time, raises efficiency in capital production. Our main results may be summarised as follows: (1) corruption is always bad for economic development, but its effect is worse if the economy is open than if it is closed; (2) the incidence of corruption may, itself, be affected by both the development and openness of the economy; (3) financial liberalisation is good for development when governance is good, but may be bad for development when governance is bad; and (4) corruption and poverty may co-exist as permanent, rather than just transitory, fixtures of an economy.
UWB-based localization in large indoor scenarios: optimized placement of anchor nodes

In this paper, we consider the problem of locating a target node (TN) moving along a corridor in a large industrial environment by means of ultrawide band signaling from fixed anchor nodes (ANs) uniformly positioned at the same height on both sides of the corridor. For a representative geometry of a large indoor (industrial) scenario, we formulate an analytical approach to the optimized placement (in terms of internode distance) of ANs using the criterion of minimizing the average mean square error (MSE) in the time-difference-of-arrival-based estimated positions of the TN. Under the assumption of a fixed variance of the range estimation error, we derive a simple closed-form expression for the optimal inter-AN distance in terms of the corridor width and the height of the ANs. The effectiveness of the analytical approach is confirmed by simulations. We also show that the proposed approach allows the MSE in the TN position estimates to reach the Cramer Rao lower bound.
Using an Error-correction Model to Test Whether Endogenous Long-run Growth Exists

A major empirical interest in growth studies is whether permanent changes in economic fundamentals affect the long-run growth rate or not. However, a direct time series analysis of this hypothesis may not always be feasible because the permanence of many such changes is rather questionable. This paper explains why examining the long-run effects of temporary changes in investment share on per capita output provides indirectly the answer regarding the effects of (possibly hypothetical) permanent changes in investment share, when per capita output and per capita investment are cointegrated. Applying the proposed method to the post-war data of major industrial countries, it is found that a disturbance to investment share does not produce a positive long-run effect in each of the four countries—France, Italy, Japan and the UK—in which per capita output and per capita investment are cointegrated. The evidence is unfavorable to the class of endogenous growth models. JEL Classification Numbers: O40; E22
Neurocognitive impairment in euthymic patients with bipolar affective disorder

Background Persistent impairments in neurocognitive function have been described in patients with bipolar disorder whose disease is in remission. However, methodological issues such as the effect of residual mood symptoms and hypercortisolaemia may confound such studies. Aims To assess neurocognitive functioning in prospectively verified euthymic patients with bipolar disorder. Method Sixty-three patients with bipolar disorder and a matched control group completed a comprehensive neurocognitive test battery. Euthymia was confirmed in the patient group by prospective clinical ratings over 1 month prior to testing. Saliva samples were collected to profile basal cortisol secretion. Results Patients were significantly impaired across a broad range of cognitive domains. Across the domains tested, clinically significant impairment was observed in 3% to 42% of patients. Deficits were not causally associated with residual mood symptoms or hypercortisolaemia. Conclusions Neurocognitive impairment persists in patients whose bipolar disorder is in remission. This may represent a trait abnormality and be a marker of underlying neurobiological dysfunction.
Impact of Prior Traumatic Life Events on Parental Early Stage Reactions following a Child's Cancer

Background In pediatric oncology, effective clinic–based management of acute and long–term distress in families calls for investigation of determinants of parents' psychological response to the child's cancer. We examined the relationship between parents' prior exposure to traumatic life events (TLE) and the occurrence of posttraumatic stress symptoms (PTSS) following their child's cancer diagnosis. Factors mediating the TLE–PTSS relationship were analyzed. Methodology The study comprised 169 parents (97 mothers, 72 fathers) of 103 cancer diagnosed children (median age: 5,9 years; range 0.1–19.7 years). Thirty five parents were of immigrant origin (20.7%). Prior TLE were collated using a standardized questionnaire, PTSS was assessed using the Impact of Events–Revised (IES–R) questionnaire covering intrusion, avoidance and hyperarousal symptoms. The predictive significance of prior TLE on PTSS was tested in adjusted regression models. Results Mothers demonstrated more severe PTSS across all symptom dimensions. TLE were associated with significantly increased hyperarousal symptoms. Parents' gender, age and immigrant status did not significantly influence the TLE–PTSS relationship. Conclusions Prior traumatic life–events aggravate posttraumatic hyperarousal symptoms. In clinic–based psychological care of parents of high–risk pediatric patients, attention needs to be paid to life history, and to heightened vulnerability to PTSS associated with female gender.
A Swedish family with de novo α -synuclein A53T mutation: Evidence for early cortical dysfunction

A de novo α -synuclein A53T (p.Ala53Thr; c.209G>A) mutation has been identified in a Swedish family with autosomal dominant Parkinson's disease (PD). Two affected individuals had early-onset (before 31 and 40 years), severe levodopa-responsive PD with prominent dysphasia, dysarthria, and cognitive decline. Longitudinal clinical follow-up, EEG, SPECT and CSF biomarker examinations suggested an underlying encephalopathy with cortical involvement. The mutated allele (c.209A) was present within a haplotype different from that shared among mutation carriers in the Italian (Contursi)
Human Platelet Antigen Alleles in 998 Taiwanese Blood Donors Determined by Sequence-Specific Primer Polymerase Chain Reaction

Polymorphism of human platelet antigens (HPAs) leads to alloimmunizations and immune-mediated platelet disorders including fetal-neonatal alloimmune thrombocytopenia (FNAIT), posttransfusion purpura (PTP), and platelet transfusion refractoriness (PTR). HPA typing and knowledge of antigen frequency in a population are important in particular for the provision of HPA-matched blood components for patients with PTR. We have performed allele genotyping for HPA-1 through -6 and -15 among 998 platelet donors from 6 blood centers in Taiwan using sequence-specific primer polymerase chain reaction. The HPA allele frequency was 99.55, and 0.45% for HPA-1a and -1b; 96.49, and 3.51% for HPA-2a and -2b; 55.81, and 44.19% for HPA-3a and -3b; 99.75, and 0.25% for HPA-4a and -4b; 98.50, and 1.50% for HPA-5a and -5b; 97.75 and 2.25% for HPA-6a and -6b; 53.71 and 46.29% for HPA-15a and -15b. HPA-15b and HPA-3a, may be considered the most important, followed by HPA-2, -6, -1, -5, and -4 systems, as a cause of FNAIT, PTP, and PTR based on allele frequency. HPA-4b and HPA-5b role cannot be excluded based on their immunogenicity. A larger-scale study will now be conducted to confirm these hypotheses and to establish an apheresis donor database for the procurement of HPA-matched apheresis platelets for patients with PTR.