Miracle-dz/UniFAR-FTUs huggingface dataset:
Pretreatment with Oxycodone Simultaneously Reduces Etomidate-Induced Myoclonus and Rocuronium-Induced Withdrawal Movements During RapidSequence Induction

Background Etomidate and rocuronium are often paired in rapid-sequence anesthesia induction. However, the effect of pretreatment with oxycodone on myoclonic and withdrawal movements has not been previously investigated. The aim of this study was to evaluate the effects of oxycodone on the incidence and severity of etomidate-induced myoclonus and rocuronium-induced nociceptive withdrawal movements during rapidsequence anesthesia induction. Material/Methods We randomly divided 120 patients into the saline group (group S) and the oxycodone group (group O) (n=60 in each group). Patients received 0.05 mg/kg oxycodone or saline intravenously 2 min before administration of 0.3 mg/kg etomidate. The occurrence and severity of myoclonus were assessed after administration of etomidate, then rocuronium was injected, followed by evaluation of withdrawal movements. Results The total frequency of involuntary movements following sequential administration of etomidate and rocuronium was significantly lower in Group O than in Group S (28.3% vs. 90%, p<0.001). The total frequency and grade 3 severity of myoclonus following etomidate injection in Group O was significantly lower than in Group S (25.0% vs. 63.3% for total frequency; 0 vs. 10 for grade 3 severity, P<0.001). The total frequency and grade 3 intensity of withdrawal movements were significantly less in Group O than in Group S (6.7% vs. 73.3% for total frequency; 0 vs. 11 for grade 3 intensity, P<0.001). Conclusions Oxycodone is effective for simultaneously preventing etomidate-induced myoclonus and rocuronium-induced withdrawal movements during general anesthesia induction.
Herpes Simplex Virus Type 1 Latency-Associated Transcripts Suppress Viral Replication and Reduce Immediate-Early Gene mRNA Levels in a Neuronal Cell Line

ABSTRACT During herpes simplex virus type 1 (HSV-1) latent infection in human dorsal root ganglia, limited viral transcription, which has been linked to HSV-1 reactivation ability, takes place. To study the involvement of this transcription in HSV-1 replication in neuronal cells and consequently in viral latency, we constructed stably transfected neuronal cell lines containing (i) the entire HSV-1 latency transcriptionally active DNA fragment, (ii) the same DNA sequence with deletions of the latency-associated transcript (LAT) promoters, or (iii) the DNA coding sequence of the LAT domain. Replication of HSV-1 or a LAT-negative mutant was markedly repressed in the LAT-expressing cells, a phenomenon mediated by the LATs. To study the mechanism responsible for this effect, we examined LAT influence upon expression of HSV-1 immediate-early (IE) genes ICP0, ICP4, and ICP27, by Northern blot analysis. Following infection of a LAT-expressing neuronal cell line with a LAT-negative mutant, the steady-state levels of all three IE mRNAs were reduced compared to those for control cells. Transient transfections into a neuronal cell line indicated that the LAT suppressive effect upon ICP0 mRNA was mediated directly and was not due to the LAT effect upon the ICP0 promoter. We therefore propose that the LATs may repress viral replication in neuronal cells by reducing IE gene mRNA levels and thus facilitate the establishment of HSV-1 latency in nervous tissue.
A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa.

PURPOSE To characterize the course of retinal disease in X-linked progressive retinal atrophy 2 (XLPRA2), a canine model of early onset X-linked retinitis pigmentosa (XLRP) caused by a two-nucleotide microdeletion in RPGR ORF15. METHODS The retinas of 25 XLPRA2-affected dogs (age range, 2-40.6 weeks) and age-matched control subjects were collected, fixed, and embedded in epoxy resin for morphologic evaluation or in optimal cutting temperature (OCT) medium for TUNEL assay and immunohistochemistry. Cell-specific antibodies were used to examine changes in rods and cones and to evaluate the effects of the primary photoreceptor degeneration on inner retinal cells. RESULTS Abnormal development of photoreceptors was recognizable as early as 3.9 weeks of age. Outer segment (OS) misalignment was followed by their disorganization and fragmentation. Reduction in length and broadening of rod and cone inner segments (IS) was next observed, followed by the focal loss of rod and cone IS at later time points. The proportion of dying photoreceptors peaked at approximately 6 to 7 weeks of age and was significantly reduced after 12 weeks. In addition to rod and cone opsin mislocalization, there was early rod neurite sprouting, retraction of rod bipolar cell dendrites, and increased Müller cell reactivity. Later in the course of the disease, changes were also noted in horizontal cells and amacrine cells. CONCLUSIONS XLPRA2 is an early-onset model of XLRP that is morphologically characterized by abnormal photoreceptor maturation followed by progressive rod-cone degeneration and early inner retina remodeling. The results suggest that therapeutic strategies for this retinal degeneration should target not solely photoreceptor cells but also inner retinal neurons.
Advances in signatures, encryption, and E-Cash from bilinear groups

We present new formal definitions, algorithms, and motivating applications for three natural cryptographic constructions. Our constructions are based on a special type of algebraic group called bilinear groups . (1) Re-signatures. We present the first public key signature scheme where a semi-trusted proxy, given special information, can translate Alice's signature on a message into Bob's signature on the same message. The special information, however, allows nothing else, i.e., the proxy cannot translate from Bob to Alice, nor can it sign on behalf of either Alice or Bob. We show that a path through a graph can be cheaply authenticated using this scheme, with applications to electronic passports. (2) Re-encryption. We present the first public key cryptosystem where a semi-trusted proxy, given special information, can translate an encryption of a message under Alice's key into an encryption of the same message under Bob's key. Again, the special information allows nothing else, i.e. the proxy cannot translate from Bob to Alice, decrypt on behalf of either Alice or Bob, or learn anything else about the message. We apply this scheme to create a new mechanism for secure distributed storage. (3) Compact e-cash with tracing and bounded-anonymity . We present an offline e-cash system where 2e coins can be stored in O(e + k) bits and withdrawn or spent in O(e + k) time, where k is the security parameter. The best previously known schemes required at least one of these complexities to be O(2 e · k). In our system, a user's transactions are anonymous and unlinkable, unless she performs a forbidden action, such as double-spending a coin. Performing a forbidden action reveals the identity of the user, and optionally allows to trace all of her past transactions. We provide solutions without using a trusted party. We argue why features of our system are likely to be crucial to the adoption of any e-cash system. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)
Risse’s deliberative logic and governance: a critical engagement

Over the last 20 years, ‘deliberation’ has become both a concept increasingly used by social science and a label for procedures many practitioners have introduced to ‘re-enchant’ democracies. Moving away from normative and political uses of the term and towards theories of public action, the four articles that follow this one pose the question when does deliberation actually take place within governance? Having first set out the contribution of existing publications on deliberation, this introductory article then presents why Thomas Risse’s definition – ‘a logic of truth seeking or arguing’ – is adopted and used throughout the articles that follow to shape and test a single analytical framework. Finally, the piece closes by presenting the individual, empirically grounded, articles that follow. Drawn from a variety of polities and scales of governance, these pieces are all inspired by a deeply sociological approach to public policymaking designed to open up decisions and deliberations to rigorous empirical enquiry.
DRhigh+CD45RA−-Tregs Potentially Affect the Suppressive Activity of the Total Treg Pool in Renal Transplant Patients

Recent studies show that regulatory T cells (Tregs) play an essential role in tolerance induction after organ transplantation. In order to examine whether there are differences in the composition of the total CD4+CD127low+/−FoxP3+- Treg cell pool between stable transplant patients and patients with biopsy proven rejection (BPR), we compared the percentages and the functional activity of the different Treg cell subsets (DRhigh+CD45RA−-Tregs, DRlow+CD45RA−-Tregs, DR−CD45RA−-Tregs, DR−CD45RA+-Tregs). All parameters were determined during the three different periods of time after transplantation (0–30 days, 31–1,000 days, >1,000 days). Among 156 transplant patients, 37 patients suffered from BPR. The most prominent differences between rejecting and non-rejecting patients were observed regarding the DRhigh+CD45RA−-Treg cell subset. Our data demonstrate that the suppressive activity of the total Treg pool strongly depends on the presence of these Treg cells. Their percentage within the total Treg pool strongly decreased after transplantation and remained relatively low during the first year after transplantation in all patients. Subsequently, the proportion of this Treg subset increased again in patients who accepted the transplant and reached a value of healthy non-transplanted subjects. By contrast, in patients with acute kidney rejection, the DRhigh+CD45RA−-Treg subset disappeared excessively, causing a reduction in the suppressive activity of the total Treg pool. Therefore, both the monitoring of its percentage within the total Treg pool and the monitoring of the HLA-DR MFI of the DR+CD45RA−-Treg subset may be useful tools for the prediction of graft rejection.
Association of Chromosome 9p21 Genetic Variants with Risk of Coronary Heart Disease in the East Asian Population: A Meta‐Analysis

Our aim was to evaluate the effect of SNPs in the 9p21 locus on genetic susceptibility of coronary heart disease in the East Asian population. We searched PubMed, EMBASE and CNKI for publications relating to the association between SNPs within the 9p21 locus and coronary heart disease in the East Asian population. This meta‐analysis was assessed by STATA 9.2. Twenty‐one studies from 15 eligible papers composing 25,945 cases and 31,777 control subjects were included in the meta‐analysis. The odds ratio (OR) and 95% confidence interval (CI) for the risk allele was 1.30 (1.25–1.35) with moderate heterogeneity. No publication bias was observed in this study. Sensitivity analysis further strengthened the validity of this association. In conclusion, SNPs within the 9p21 locus were strongly associated with the risk of coronary heart disease in the East Asian population with a similar risk OR to the Caucasian population.
Striving for the Moral Self: The Effects of Recalling Past Moral Actions on Future Moral Behavior

People’s desires to see themselves as moral actors can contribute to their striving for and achievement of a sense of self-completeness. The authors use self-completion theory to predict (and show) that recalling one’s own (im)moral behavior leads to compensatory rather than consistent moral action as a way of completing the moral self. In three studies, people who recalled their immoral behavior reported greater participation in moral activities (Study 1), reported stronger prosocial intentions (Study 2), and showed less cheating (Study 3) than people who recalled their moral behavior. These compensatory effects were related to the moral magnitude of the recalled event, but they did not emerge when people recalled their own positive or negative nonmoral behavior (Study 2) or others’ (im)moral behavior (Study 3). Thus, the authors extend self-completion theory to the moral domain and use it to integrate the research on moral cleansing (remunerative moral strivings) and moral licensing (relaxed moral strivings).
Using dairy herd improvement records and clinical mastitis history to identify subclinical mastitis infections at dry-off

Interest in selective dry cow therapy (SDCT) has been increasing owing to concerns over development of antimicrobial resistance. Implementation of SDCT, however, requires a quick and cost-effective on-farm method for identifying cows for treatment and cows that can be left without treatment. The objective of the present study was to evaluate the use of clinical mastitis (CM) history and somatic cell counts (SCC) from monthly Dairy Herd Improvement (DHI) records in identification of infected and uninfected cows at dry-off. A total of 647 Holstein cows were classified as uninfected or infected at dry-off based on CM history and varying number of monthly SCC records (with three different SCC cut-offs). Cows were considered uninfected based on the following criteria: (1) SCC <100 000 cells/ml and no CM during the lactation; (2) SCC <200 000 cells/ml and no CM during the lactation; (3) as criterion two, but additionally a cow was also considered uninfected if it experienced a case of CM during the first 3 months of the lactation and the SCC was <100 000 cells/ml for the rest of the lactation; (4) SCC <300 000 cells/ml and no CM during the lactation; otherwise they were considered infected. Infected and uninfected cows at dry-off were most efficiently identified using three months' SCC records with a threshold of 200 000 cells/ml for cows without CM during the lactation and a threshold of 100 000 cells/ml during the rest of lactation for cows with CM during the first 90 days in milk. Moreover, this criterion also most efficiently identified cows infected with major pathogens only at dry-off. The success of the criteria used for identifying infected and uninfected cows will, however, depend on herd characteristics, such as prevalence of infection and type of pathogens present in the herd.
Association of Hospital and Provider Types on Sickle Cell Disease Outcomes

OBJECTIVES: Adolescents and young adults (A/YA) with sickle cell disease (SCD) are hospitalized in both children’s and general hospitals. We determined the effect of hospital type and provider specialty on outcomes of hospitalized A/YA with SCD and acute chest syndrome (ACS). METHODS: This retrospective cohort study used the 2007–2009 Premier Database, a large multi-institutional database, to identify 1476 patients ages 16 to 25 years with 2299 admissions with SCD and ACS discharged from 256 US hospitals from 2007 to 2009. Multilevel logistic regression and zero-truncated negative binomial regression were performed after adjustment for patient demographic, clinical, and hospital characteristics to test the association of hospital type and provider specialty on death, endotracheal intubation, simple or exchange transfusion, length of stay (LOS), and 30-day readmission. RESULTS: Of all admissions, 14 died and 45% were intubated. General hospitals had 13 deaths and were associated with higher intubation rates (predicted probability [PP], 48% [95% confidence interval (CI), 43%–52%]) and longer LOS (predicted mean LOS, 7.6 days [95% CI, 7.2–7.9]) compared with children’s hospitals (PP of intubation, 24% [95% CI, 5%–42%]; and predicted mean LOS, 6.8 days [95% CI, 5.6–5.8]). There was no difference by hospital type or provider specialty in PP of simple or exchange transfusion, or 30-day readmission. CONCLUSIONS: General hospitals carry higher intubation risks for A/YA with SCD and ACS compared with children’s hospitals. We need to better understand the drivers of these differences, including the role of staff expertise, hospital volume, and quality of ongoing SCD care.
Supervisory Control of Distributed Systems: Conflict Resolution

In distributed synthesis and control, one well-known potential hazard is conflict between modular designs. In a modular approach to the supervisory control of discrete-event systems, modular supervisors that are individually nonblocking (with respect to the plant) may nevertheless conflict and thus produce blocking, or even deadlock, when operating concurrently. A scheme of resolving this potential conflict between the modular supervisors would be to accord priorities to the conflicting supervisors. When conflict arises, the modular supervisor that is assigned a higher priority will have sole control, or in other words the control action of the lower priority supervisor will be suspended. Thus by assigning priority appropriately, control actions of the modular supervisors will be suspended and reactivated in such a way that the potential conflict can be averted. In this article we formalize this scheme with reporter maps from a hierarchical approach to the supervisory control of discrete-event systems. These maps, each acting as an interface between a modular supervisor and the plant, mediate the flow of information and control, and thus in this way achieve suspension and reactivation of the modular supervisors. Sufficient conditions on these reporter maps for conflict resolution are obtained. Roughly speaking, the conditions are that (1) the reporter maps select suitable ‘subsystems’ of the plant; (2) within these subsystems, conflicts are ‘resolved’; (3) the reporter maps are ‘refined’ enough to lift these local conflict resolutions back to the original plant. With these conditions, a constructive solution is developed, which in essence suspends a supervisor ‘just in time’ to prevent conflict and reactivates it when the plant and the other supervisor return to the state they were in when the suspension began. Examples inspired by the feature interaction problem in telecommunication systems are provided for illustration.
Applying species‐sensitivity distributions in ecological risk assessment: Assumptions of distribution type and sufficient numbers of species

Species‐sensitivity distribution methods assemble single‐species toxicity data to predict hazardous concentrations (HCps) affecting a certain percentage (p) of species in a community. The fit of the lognormal model and required number of individual species values were evaluated with 30 published data sets. The increasingly common assumption that a lognormal model best fits these data was not supported. Fifteen data sets failed a formal test of conformity to a lognormal distribution; other distributions often provided better fit to the data than the lognormal distribution. An alternate bootstrap method provided accurate estimates of HCp without the assumption of a specific distribution. Approximate sample sizes producing HC5 estimates with minimal variance ranged from 15 to 55, and had a median of 30 species‐sensitivity values. These sample sizes are higher than those suggested in recent regulatory documents. A bootstrap method is recommended that predicts with 95% confidence the concentration affecting 5% or fewer species.
Biomechanical predictors of ball velocity during punt kicking in elite rugby league kickers

Punt kicking is integral to the attacking and defensive elements of rugby league and the ability to kick the ball with high velocity is desirable. This study aimed to identify important technical aspects of kicking linked to the generation of ball velocity. Maximal punt kicks were obtained from six elite rugby league kickers using a 10-camera motion capture system. Three-dimensional kinematics of the lower extremities was obtained. Regression analysis with ball velocity as criterion was used to identify the kinematic parameters associated with the development of ball velocity. The regression model yielded an adj R2 = 0.76, p ≤ 0.01. Two parameters were identified: knee extension angular velocity of the kicking limb at impact (R2 = 0.50) and peak flexion angular velocity of the kicking hip (R2 = 0.26, p ≤ 0.01). It is conceivable that players may benefit from exposure to coaching and strength techniques geared toward the modification of kicking mechanics specific to this study.
On a Refinement of Wilf-equivalence for Permutations

Recently, Dokos et al. conjectured that for all $k, m\geq 1$, the patterns $ 12\ldots k(k+m+1)\ldots (k+2)(k+1) $ and $(m+1)(m+2)\ldots (k+m+1)m\ldots 21$ are $maj$-Wilf-equivalent. In this paper, we confirm this conjecture for all $k\geq 1$ and $m=1$. In fact, we construct a descent set preserving bijection between $ 12\ldots k (k-1) $-avoiding permutations and $23\ldots k1$-avoiding permutations for all $k\geq 3$. As a corollary, our bijection enables us to settle a conjecture of Gowravaram and Jagadeesan concerning the Wilf-equivalence for permutations with given descent sets.
Risk Factors for Pulmonary Artery Hypertension in Preterm Infants with Moderate or Severe Bronchopulmonary Dysplasia

Background: Despite the potential importance of pulmonary artery hypertension (PAH) in preterm infants with bronchopulmonary dysplasia (BPD), little is known about the risk factors for PAH. Objectives: To investigate the risk factors for PAH in preterm infants with BPD. Methods: Infants diagnosed with BPD were assigned to the PAH group or non-PAH group except for infants with mild BPD who had no PAH. PAH was diagnosed on the basis of echocardiograms demonstrating elevated right ventricle pressure beyond the postnatal age of 2 months. Logistic regression analysis was done for the multivariate assessment of the risk factors for PAH in preterm infants with moderate or severe BPD. Results: A total of 98 infants among 145 infants with BPD were divided into a PAH group (n = 25) or non-PAH group (n = 73), while the remaining 47 infants had mild BPD with no PAH. Among the study patients, survival rate of the PAH group was significantly lower than that of the non-PAH group. Infants with PAH had more severe cases of BPD and underwent longer durations of oxygen therapy, conventional or high-frequency ventilation, and hospitalization compared to those without PAH. Low 5-min Apgar scores (≤6; relative risk (RR) 6.2; 95% confidence interval (CI) 1.4–28.0; p = 0.017) and oligohydramnios (RR 7.7; 95% CI 2.0–29.6; p = 0.030) were found to be significant risk factors for PAH according to multivariate analysis. Conclusions: The present study shows that oligohydramnios is a specific risk factor for PAH in preterm infants with moderate or severe BPD.