Miracle-dz/UniFAR-FTUs huggingface dataset:
Hyponatremia caused by excessive intake of water as a form of child abuse

Hyponatremia is the most common electrolyte disorder that requires careful management. Water intoxication with hyponatremia is rare condition that originated from overhydration. Water intoxication, also known as dilutional hyponatremia, develops only because the intake of water exceeds the kidney's ability to eliminate water. Causes of this water intoxication include psychiatric disorder, forced water intake as a form of child abuse and iatrogenic infusion of excessive hypotonic fluid. We experienced and reported a case of symptomatic hyponatremia by forced water intake as a form of child abuse.
Stress and Blood Pressure in Kuna Amerinds

Is migration from isolated indigenous island communities to Panama City associated with an increase in stress? Individuals were randomly sampled from two Kuna communities: 325 individuals in Panama City and 133 on a Caribbean island. Stress was assessed through the Milcom questionnaire, which explores physical symptoms and symptoms relevant to mood and emotional state, and Cantril's ladder, which examines life satisfaction. Physical symptoms were more common in the urban community (p<0.001), and complaints reflecting mood were also significantly higher on the mainland (p<0.001); the two measures were highly correlated. While systolic and diastolic blood pressure was higher in the mainland community (p<0.001), there was no relation between blood pressure level and any index of stress. Despite unambiguous evidence of an increase in stress in migrants to the city, there was no indication that the stress contributed to the rise in blood pressure level. Migration to an urban setting is associated with an increase in physical symptoms and symptoms reflecting depressed mood, suggesting increased stress level. Life satisfaction is less influenced, possibly providing a measure of the degree of stress.
Influence of temperature on brittle creep in sandstones

The characterization of time‐dependent brittle creep, promoted by chemically active pore fluids, is fundamental to our understanding of the long‐term evolution and dynamics of the Earth's crust. Here we report results from a study of the influence of temperature on both short‐term strength and time‐dependent brittle creep in three sandstones under triaxial stress conditions. We show that an increase in temperature from 20° to 75°C significantly enhances stress corrosion cracking in all three sandstones, leading to (1) a systematic reduction in strength during constant strain rate experiments and (2) an increase by several orders of magnitude in brittle creep strain rates during stress‐stepping creep experiments. We also show that a conventional creep experiment performed at 75°C exhibits a qualitatively similar three‐stage brittle creep curve as that observed at ambient temperature. Extrapolation of our results suggests that temperature is likely to be the dominant influence on the evolution of creep strain rate with depth in the shallow crust.
Erratum: The history of star formation in dusty galaxies

A population of distant dusty galaxies emitting in the submillimetre waveband has recently been detected using the Submillimetre Common-User Bolometer Array (SCUBA) camera on the James Clerk Maxwell Telescope (JCMT). This population can be used to trace the amount of high-redshift star formation activity that is obscured from view in the optical waveband by dust, and so is missing from existing inventories of star formation in the distant Universe. By including this population we can construct a complete and consistent picture of the history of star formation. The evolution of obscured star formation at redshifts less than unity is constrained by mid- and far-infrared counts of dusty galaxies. Activity increases with redshift z as (1+z)γ with γ∼ 4, consistent with the form of evolution found in the optical waveband by the Canada--France Redshift Survey (CFRS) to z≤ 1. The form of evolution at higher redshifts is constrained by both faint SCUBA counts and the intensity of background radiation in the millimetre/submillimetre waveband. We find that the total amount of energy emitted by dusty galaxies is about four times greater than that inferred from rest frame ultraviolet observations, and that a larger fraction of this energy is emitted at high redshifts. The simplest explanation for these results is that a large population of luminous, strongly obscured sources at redshifts z≤ 5 is missing from optical surveys. We discuss the possible contribution of obscured active galactic nuclei to the submillimetre-wave background and counts. More accurate constraints on the history of star formation will be provided by determinations of the counts in several submillimetre wavebands and crucially by a reliable redshift distribution of the detected galaxies.
Student perceptions of the teaching in online learning: and Australian university case study

This research paper was reviewed using a double blind peer review process that meets DIISR requirements. Two reviewers were appointed on the basis of their independence and they reviewed the full paper devoid of the authors’ names and institutions in order to ensure objectivity and anonymity. Papers were reviewed according to specified criteria, including relevance to the conference theme and sub-themes, originality, quality and presentation. Following review and acceptance, this full paper was presented at the international conference.
Purified protein derivative testing and tuberculosis preventive therapy for HIV‐infected patients in New York City

Objective:To determine whether Centers for Disease Control and Prevention recommendations for purified protein derivative (PPD) testing and tuberculosis (TB) preventive therapy for PPD-positive patients are implemented in HIV clinics. Design:Retrospective medical chart review. Setting:Ten hospital-based HIV clinics in New York City. Participants:A total of 2397 patients with a first clinic visit in 1995. Outcome measures:PPD testing of eligible patients, and recommendation of preventive therapy and completion of regimen in PPD-positive patients. Method:Outpatient medical records were abstracted for TB history, PPD testing, TB preventive therapy, and patient demographic, social and clinical characteristics. Multivariate analyses were performed using logistic regression. Results:Of 1342 patients with an indication for a PPD test, 865 (64%) were PPD tested in the clinic and 757 (88%) returned to have it read. Factors strongly associated with PPD testing in the clinic were number of visits, same sex behavior with men, and CD4+ lymphocyte count above 200 × 106/l. Preventive therapy was recommended for 80% of newly identified PPD-positive patients and 22% of previously identified PPD-positive patients. Of 119 patients on preventive therapy in the clinic, 49 (41%) completed the regimen, 50 (42%) were lost to follow-up, and 20 (17%) discontinued therapy or their status could not be determined. Conclusion:A significant number of missed opportunities to implement TB prevention practices were identified in HIV clinics. Focused attention in HIV clinics, and increased collaboration between HIV clinics and TB control programs may be needed to increase adherence to prevention guidelines.
Health-related quality of life data from a phase 3, international, randomized, open-label, multicenter study in patients with previously treated mantle cell lymphoma treated with ibrutinib versus temsirolimus

Abstract Mantle cell lymphoma (MCL) is a rare, aggressive, incurable B-cell malignancy. Ibrutinib has been shown to be highly active for patients with relapsed/refractory (R/R) MCL. The RAY trial (MCL3001) was a phase 3, randomized, open-label, multicenter study that compared ibrutinib with temsirolimus in patients with R/R MCL. Active disease is frequently associated with impaired functional status and reduced well-being. Therefore, the current study employed two patient-reported outcome instruments, the Functional Assessment of Cancer Therapy-Lymphoma (FACT-Lym) and the EQ-5D-5L, to assess symptoms, well-being, health status, and health-related quality of life of patients on treatment within the RAY trial. We found that patients on ibrutinib had substantial improvement in FACT-Lym subscale and total scores, and had improvement in EQ-5D-5L utility and VAS scores compared with temsirolimus patients, indicating a superior well-being. These improvements in well-being correlated with clinical response, indicating that better health-related quality of life was associated with decreased disease burden.
A Soluble Isoform of the Rhesus Monkey Nonclassical MHC Class I Molecule Mamu-AG Is Expressed in the Placenta and the Testis1

The nonclassical MHC class I locus HLA-G is expressed primarily in the placenta, although other sites of expression have been noted in normal and pathological situations. In addition, soluble HLA-G isoforms have been detected in the serum of pregnant and nonpregnant women as well as men. The rhesus monkey placenta expresses a novel nonclassical MHC class I molecule Mamu-AG, which has features remarkably similar to those of HLA-G. We determined that the rhesus placenta expresses Mamu-AG mRNA (Mamu-AG5), retaining intron 4 as previously noted in HLA-G5. Immunostaining experiments with Ab 16G1 against the soluble HLA-G5 intron 4 peptide demonstrated that an immunoreactive protein(s) was present in the syncytiotrophoblasts of the chorionic villi of the rhesus placenta, within villous cytotrophoblasts, and occasionally within cells of the villous stroma. The Mamu-AG5 mRNA was readily detected in rhesus testis (although not in ejaculated sperm). Whereas an Ab against membrane-bound Mamu-AG stained few cells, primarily in the interstitium of the testis, there was consistent immunostaining for Mamu-AG5 in cells within the seminiferous tubules, which was corroborated by localization of Mamu-AG mRNA by in situ hybridization. While primary spermatocytes were negative, Sertoli cells, spermatocytes, and spermatids were consistently positive for 16G1 immunostaining. The specific recognition of the soluble Mamu-AG isoform was confirmed by Western blotting of Mamu-AG5 expressed in heterologous cells. The results demonstrate that a soluble nonclassical MHC class I molecule is expressed in the rhesus monkey placenta and testis, and confirm and extend the unique homology between HLA-G and the rhesus nonclassical molecule Mamu-AG.
Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication

The high efficacy of therapeutic cancer vaccines in preclinical studies has yet to be fully achieved in clinical trials. Tumor immune suppression is a critical factor that hampers the desired antitumor effect. Here, we analyzed the combined effect of a cancer vaccine and the receptor tyrosine kinase inhibitor sunitinib. Sunitinib was administered intraperitoneally, alone or in combination with intramuscular immunization using a viral vector based cancer vaccine composed of Semliki Forest virus replicon particles and encoding the oncoproteins E6 and E7 (SFVeE6,7) of human papilloma virus (HPV). We first demonstrated that treatment of tumor-bearing mice with sunitinib alone dose-dependently depleted myeloid-derived suppressor cells (MDSCs) in the tumor, spleen and in circulation. Concomitantly, the number of CD8+ T cells increased 2–fold and, on the basis of CD69 expression, their activation status was greatly enhanced. The intrinsic immunosuppressive activity of residual MDSCs after sunitinib treatment was not changed in a dose-dependent fashion. We next combined sunitinib treatment with SFVeE6,7 immunization. This combined treatment resulted in a 1.5- and 3-fold increase of E7-specific cytotoxic T lymphocytes (CTLs) present within the circulation and tumor, respectively, as compared to immunization only. The ratio of E7-specific CTLs to MDSCs in blood thereby increased 10- to 20-fold and in tumors up to 12.5-fold. As a result, the combined treatment strongly enhanced the antitumor effect of the cancer vaccine. This study demonstrates that sunitinib creates a favorable microenvironment depleted of MDSCs and acts synergistically with a cancer vaccine resulting in enhanced levels of active tumor-antigen specific CTLs, thus changing the balance in favor of antitumor immunity.
Combine Performance Descriptors and Predictors of Recruit Ranking for the Top High School Football Recruits from 2001 to 2009: Differences between Position Groups

Ghigiarelli, JJ. Combine performance descriptors and predictors of recruit ranking for the top high school football recruits from 2001 to 2009: Differences between position groups. J Strength Cond Res 25(5): 1193-1203, 2011-Several studies have documented the normative data for football combine performance measures in college and professional players. The primary purpose of this study was to examine the anthropometric and combine performance differences between highly recruited and recruited high school football players. A secondary purpose was to provide a historical basis of descriptive data for elite high school football players from 2001 to 2009. Height, weight, 40-yd sprint time, 20-yd shuttle time, vertical jump height, angle drive drill time, and broad jump distance were extracted for 2,560 players from a commercially available website. Mean scores across star value and playing positions were compared using analysis of variance (ANOVA) and 1-way ANOVAs. Statistical significance was found between highly recruited (5 and 4 stars) and recruited players (3 and 2 stars) for height (highly recruited = 1.878 ± 0.06 m, recruited 1.85 ± 0.11 m), weight (highly recruited = 99.77 ± 4.76 kg, recruited = 97.54 ± 4.84 kg), 40-yd sprint (highly recruited = 4.76 ± 0.327 seconds, recruited = 4.84 ± 0.142 seconds), and vertical jump (highly recruited = 0.775 ± 0.11 m, recruited = 0.750 ± 0.121 m). Ten backward stepwise regression models were calculated (position × variables) with statistical significance set at the p < 0.05 level. The 40-yd sprint time, height, and weight were significant predictors of star value across 10 positions. These data provide anthropometric and performance profiles for highly recruited high school football players. Sprinting ability and physical size are the most consistent predictors of subjective ranking. The results may help strength and conditioning specialists better understand the anthropometric and physical attributes that distinguish highly recruited from recruited players and which attributes are likely to predict higher star value scores.
Acupuncture and/or sweeping of the fetal membranes before induction of labor: a prospective, randomized, controlled trial

Abstract Aims: To evaluate the efficacy of acupuncture, and sweeping of the fetal membranes, as methods for induction of labor. Methods: Four hundred and seven pregnant women with normal singleton pregnancies and cephalic presentations were randomized at three delivery wards in Denmark at day 290 of gestation into groups of acupuncture, sweeping, acupuncture and sweeping and controls. The primary objective was to compare the proportion of women going into labor before induction of labor at 294 days in the four groups. The secondary objective was to compare the combined groups: with and without acupuncture, and with and without sweeping of the fetal membranes. The midwives, completing the forms for the trial at labor or induction, were blinded to group assessments. Results: Four hundred and seventeen women were randomized. Ten were excluded after randomization. One hundred and four women were randomized to acupuncture, 103 to sweeping of the membranes, 100 to both acupuncture and sweeping, and 100 were randomized to the control group. Comparison of the four groups demonstrated no significant difference in the number of women achieving spontaneous labor before planned induction. No difference was demonstrated by comparing the combined groups treated with acupuncture with the groups not treated with acupuncture (P=0.76). However, significantly more women went into labor before planned induction (P=0.02) in the combined groups receiving sweeping, compared with the groups not treated with sweeping. Conclusions: Acupuncture at 41+ weeks of gestation did not reduce the need for induction. The study was of a sufficient size to demonstrate, in parallel, that sweeping of the fetal membranes significantly reduced the need of induction, sparing about 15% for formal induction of labor.
Clinical Features and Genetic Background of the Periodic Fever Syndrome with Aphthous Stomatitis, Pharyngitis, and Adenitis: A Single Center Longitudinal Study of 81 Patients

PFAPA syndrome is the most common autoinflammatory disorder in childhood with unknown etiology. The aim of our study was clinical evaluation of PFAPA patients from a single tertiary care center and to determine whether variations of AIM2, MEFV, NLRP3, and MVK genes are involved in PFAPA pathogenesis. Clinical and laboratory data of consecutive patients with PFAPA syndrome followed up at the University Children's Hospital, Ljubljana, were collected from 2008 to 2014. All four genes were PCR amplified and directly sequenced. Eighty-one patients fulfilled criteria for PFAPA syndrome, 50 (63%) boys and 31 (37%) girls, with mean age at disease onset of 2.1 ± 1.5 years. Adenitis, pharyngitis, and aphthae were present in 94%, 98%, and 56%, respectively. Family history of recurrent fevers in childhood was positive in 78%. Nineteen variants were found in 17/62 (27%) patients, 4 different variants in NLRP3 gene in 13 patients, and 6 different variants in MEFV gene in 5 patients, and 2 patients had 2 different variants. No variants of clinical significance were found in MVK and AIM2 genes. Our data suggest that PFAPA could be the result of multiple low-penetrant variants in different genes in combination with epigenetic and environmental factors leading to uniform clinical picture.
Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1

Significance Protein misfolding can lead to neurodegeneration. Yet, the mechanistic details of this deleterious phenomenon are largely unknown, as experimental portrayals of the early and reversible molecular events leading to misfolded conformations have so far remained highly limited. Here we use single-molecule optical tweezers to monitor the structural rearrangements leading to misfolded conformations of human neuronal calcium sensor-1, a protein linked to serious neurological disorders. We identified two distinct and calcium-dependent misfolding trajectories originating from an on-pathway folding intermediate. Remarkably for a calcium sensor, pathologically high calcium concentrations impede correct folding by increasing the occupation probabilities of the misfolded states. The results open ostensible links between protein misfolding and calcium dysregulation that could be important in neurodegeneration and its potential inhibition. Neurodegenerative disorders are strongly linked to protein misfolding, and crucial to their explication is a detailed understanding of the underlying structural rearrangements and pathways that govern the formation of misfolded states. Here we use single-molecule optical tweezers to monitor misfolding reactions of the human neuronal calcium sensor-1, a multispecific EF-hand protein involved in neurotransmitter release and linked to severe neurological diseases. We directly observed two misfolding trajectories leading to distinct kinetically trapped misfolded conformations. Both trajectories originate from an on-pathway intermediate state and compete with native folding in a calcium-dependent manner. The relative probability of the different trajectories could be affected by modulating the relaxation rate of applied force, demonstrating an unprecedented real-time control over the free-energy landscape of a protein. Constant-force experiments in combination with hidden Markov analysis revealed the free-energy landscape of the misfolding transitions under both physiological and pathological calcium concentrations. Remarkably for a calcium sensor, we found that higher calcium concentrations increased the lifetimes of the misfolded conformations, slowing productive folding to the native state. We propose a rugged, multidimensional energy landscape for neuronal calcium sensor-1 and speculate on a direct link between protein misfolding and calcium dysregulation that could play a role in neurodegeneration.
Selective omission of the donor cross-match before renal transplantation: efficacy, safety and effects on cold storage time.

BACKGROUND A donor lymphocyte cross-match (XM) test performed before renal transplantation is considered mandatory but may delay the transplant and increase the cold storage time. With careful documentation of sensitizing events and with knowledge of previous antibody screening results, it is often possible to predict the XM result for a given donor HLA mismatch. In this study, a policy was adopted of omitting the pretransplant XM in patients in whom a negative result was predicted with absolute confidence. METHODS Recipients were selected for cadaveric donor kidney transplantation using a computer algorithm based on HLA match, sensitization status, time on the waiting list and donor and recipient age. The immediate pretransplant cross-match test was omitted in non-sensitized recipients and in sensitized recipients where antibody specificities were precisely defined and not against donor HLA. RESULTS From October 1997 to May 1999, 53 of 96 (55%) consecutive cadaveric kidney donor transplants were performed without a pretransplant XM. In all cases, a negative donor HLA-specific antibody XM was confirmed after transplantation. Omission of the pre-transplant XM was associated with a significant reduction in cold ischemic time (15.0 hr vs. 18.2 hr, P=0.01) and a reduced incidence of delayed graft function (13% vs. 33%, P=0.03). However, there was no difference in transplant outcome at 1 year. CONCLUSION Rigorous attention to priming events together with careful antibody screening allows the pre-transplant XM test to be safely omitted in approximately half the patients awaiting renal transplantation. This policy allows a modest reduction in cold ischemia time, but it remains to be seen whether this is of clinical benefit.
PARENTAL KNOWLEDGE OF BEHAVIORAL PRINCIPLES FOLLOWING TRAINING TO ADDRESS SLEEP PROBLEMS IN CHILDREN WITH AUTISM SPECTRUM DISORDERS: A FOLLOW-UP STUDY

Sleep problems are a common occurrence among children with autism spectrum disorders (ASD). In addition to the challenges that sleep problems present for children’s neurodevelopment, learning, and daytime behaviors, sleep problems in children present significant challenges for the entire family. Research studies on behavioral interventions to address sleep problems in young children have shown them to be effective. These interventions have often been combined in multi-component behavioral parent training (BPT) programs to teach parents to assess and intervene to improve children’s various sleep problems. Although there is a promising evidence base emerging that demonstrates the effectiveness of BPT as a model to address sleep problems in young children with ASD, research on parents’ knowledge and generalization of behavioral methods has been nearly absent in this line of inquiry. This research study evaluated maintenance and generalization of parent knowledge 6-12 months following parents’ participation in a randomized controlled trial (RCT). Parents’ knowledge of behavioral methods, children’s sleep behaviors, parents’ ratings of stress and other demographic factors (e.g., education and income) were compared between a BPT group and a psycho-educational group of the RCT. Additionally, results from a brief qualitative interview are presented to assess parents’ performance in addressing children’s sleep behavior. The results of this follow-up study as well as recommendations for future research will be discussed.