Miracle-dz/UniFAR-FTUs huggingface dataset:
Real-time pharmacy surveillance and clinical decision support to reduce adverse drug events in acute kidney injury

Summary Objectives: Clinical decision support (CDS), such as computerized alerts, improves prescribing in the setting of acute kidney injury (AKI), but considerable opportunity remains to improve patient safety. The authors sought to determine whether pharmacy surveillance of AKI patients could detect and prevent medication errors that are not corrected by automated interventions. Methods: The authors conducted a randomized clinical trial among 396 patients admitted to an academic, tertiary care hospital between June 1, 2010 and August 31, 2010 with an acute 0.5 mg/dl change in serum creatinine over 48 hours and a nephrotoxic or renally cleared medication order. Patients randomly assigned to the intervention group received surveillance from a clinical pharmacist using a web-based surveillance tool to monitor drug prescribing and kidney function trends. CDS alerting and standard pharmacy services were active in both study arms. Outcome measures included blinded adjudication of potential adverse drug events (pADEs), adverse drug events (ADEs) and time to provider modification or discontinuation of targeted nephrotoxic or renally cleared medications. Results: Potential ADEs or ADEs occurred for 104 (8.0%) of control and 99 (7.1%) of intervention patient-medication pairs (p=0.4). Additionally, the time to provider modification or discontinuation of targeted nephrotoxic or renally cleared medications did not differ between control and intervention patients (33.4 hrs vs. 30.3hrs, p=0.3). Conclusions: Pharmacy surveillance had no incremental benefit over previously implemented CDS alerts
An empathic virtual dialog agent to improve human-machine interaction

Recent research has shown that virtual agents expressing empathic emotions toward users have the potentiality to enhance human-machine interaction. To identify under which circumstances a virtual agent should express empathic emotions, we have analyzed real human-machine dialog situations that have led users to express emotion. The results of this empirical study have been combined with theoretical descriptions of emotions to construct a model of empathic emotions. Based on this model, a module of emotions has been implemented as a plug-in for JSA agents. It determines the empathic emotions (their types and intensity) of such agents in real time. It has been used to develop a demonstrator where users can interact with an empathic dialog agent to obtain information on their emails. An evaluation of this agent has enabled us to both validate the proposed model of empathic emotions and highlight the positive user's perception of the virtual agent.
Functional Heterogeneity of Macaque Lateral Intraparietal Neurons

The macaque lateral intraparietal area (LIP) has been implicated in many cognitive processes, ranging from saccade planning and spatial attention to timing and categorization. Importantly, different research groups have used different criteria for including LIP neurons in their studies. While some research groups have selected LIP neurons based on the presence of memory-delay activity, other research groups have used other criteria such as visual, presaccadic, and/or memory activity. We recorded from LIP neurons that were selected based on spatially selective saccadic activity but regardless of memory-delay activity in macaque monkeys. To test anticipatory climbing activity, we used a delayed visually guided saccade task with a unimodal schedule of go-times, for which the conditional probability that the go-signal will occur rises monotonically as a function of time. A subpopulation of LIP neurons showed anticipatory activity that mimicked the subjective hazard rate of the go-signal when the animal was planning a saccade toward the receptive field. A large subgroup of LIP neurons, however, did not modulate their firing rates according to the subjective hazard function. These non-anticipatory neurons were strongly influenced by salient visual stimuli appearing in their receptive field, but less so by the direction of the impending saccade. Thus, LIP contains a heterogeneous population of neurons related to saccade planning or visual salience, and these neurons are spatially intermixed. Our results suggest that between-study differences in neuronal selection may have contributed significantly to the findings of different research groups with respect to the functional role of area LIP.
Who is dominating the Dutch neighbourhood? On the role of subsyllabic units in Dutch nonword reading

To assess the role of the subsyllabic units onset–nucleus (ON; spa rk) and rime (sp ark ) in Dutch visual word recognition, we compared lexical decisions to four groups of nonwords in which the existence of ONs and rimes was orthogonally manipulated. Nonwords with existent ONs and/or rimes were rejected more slowly and less accurately. ON and rime neighbours thus influence Dutch nonword reading to the same extent. Simulations with the interactive activation model (McClelland & Rumelhart, 1981) revealed that this model with left-to-right coded representations could not replicate the effects found in the lexical decision data whereas an adapted version with representations of onset, nucleus, and coda could. Effects of the larger units ON and rime emerged from activation patterns created by the smaller units onset, nucleus, and coda.
The Biological Variation of N-Terminal Pro-Brain Natriuretic Peptide in Postmenopausal Women with Type 2 Diabetes: A Case Control Study

Background The incidence of heart failure in type 2 diabetes is high and it has poorer prognosis when compared with patients without diabetes. Access to echocardiography is limited and alternative methods to identify early heart failure such as the measurement of natriuretic peptides levels have been proposed. However, their wide biological variation could limit their clinical utility. Our aim was to determine if the intrinsic biological variation of one of these peptides, N-terminal proBNP, is as wide in type 2 diabetes as it is in health and to calculate the critical difference values that could be utilised in clinical practice to ensure changes observed between two samples are due to intervention rather than to its biological variability. Methodology/Principal Findings 12 postmenopausal women with diet controlled type 2 diabetes and without heart failure were compared with 11 control postmenopausal women without diabetes. N-terminal proBNP levels were measured on 10 occasions. The biological variation was calculated according to Fraser's methods. The mean NT-proBNP level was similar in both groups (mean ± standard deviation; type 2 diabetes, 10.7 pmol/L± 8.5 versus 8.49±6.0 pmol/L, p = 0.42). The biological variation was also similarly wide. The critical difference in patients with type 2 diabetes was between −70% and ±236%. Conclusions Type 2 diabetes does not appear to significantly influence the marked biological variation of N-terminal proBNP in postmenopausal women. The critical difference values reported in this study could be used to titrate therapy or monitor response to interventions although the change required in between samples is wide and this might limit its utility.
Hemorrhage Burden Predicts Recurrent Intracerebral Hemorrhage After Lobar Hemorrhage

Background and Purpose— Small asymptomatic cerebral hemorrhages detectable by gradient-echo MRI are common in patients with intracerebral hemorrhage (ICH), particularly lobar ICH related to cerebral amyloid angiopathy (CAA). We sought to determine whether hemorrhages detected at the time of lobar ICH predict the major clinical complications of CAA: recurrent ICH or decline in cognition and function. Methods— Ninety-four consecutive survivors of primary lobar ICH (age ≥55) with gradient-echo MRI at presentation were followed in a prospective cohort study for 32.9±24.0 months. A subset of 34 subjects underwent a second MRI after a stroke-free interval of 15.8±6.5 months. Study endpoints were recurrent symptomatic ICH or clinical decline, defined as onset of cognitive impairment, loss of independent functioning, or death. Results— The total number of hemorrhages at baseline predicted risk of future symptomatic ICH (3-year cumulative risks 14%, 17%, 38%, and 51% for subjects with 1, 2, 3 to 5, or ≥6 baseline hemorrhages, P = 0.003). Higher numbers of hemorrhages at baseline also predicted increased risk for subsequent cognitive impairment, loss of independence, or death (P = 0.002) among subjects not previously demented or dependent. For subjects followed after a second MRI, new microhemorrhages appeared in 17 of 34 and predicted increased risk of subsequent symptomatic ICH (3-year cumulative risks 19%, 42%, and 67% for subjects with 0, 1 to 3, or ≥4 new microhemorrhages, P = 0.02), but not subsequent clinical decline. Conclusions— Hemorrhages identified by MRI predict clinically important events in survivors of lobar ICH. Detection of microhemorrhages may be useful for assessing risk in ICH patients and as a surrogate marker for clinical studies.
Investigation of Drying Shrinkage of Concrete Prepared with Iron Mine Tailings

Concretes of C30 and C60 were prepared with iron mine tailings as fine aggregate and coarse aggregate and with natural sand and common crushed stone separately. The drying shrinkage of concretes cured under the natural condition in the laboratory was tested. The results showed that whether C30 or C60 the drying shrinkage of concrete prepared with iron mine tailings was a little smaller than that of concrete with natural sand and common crushed stone. It was also found that whether the concrete with iron mine tailings or the concrete with natural sand and common crushed stone the drying shrinkage of C60 concrete was larger than that of C30 concrete.
Repeatability and inter-device agreement for three different methods of keratometry: Placido, Scheimpflug, and color LED corneal topography.

PURPOSE To determine the repeatability of a color LED corneal topographer (Cassini; iOptics, The Hague, The Netherlands) and compare it with Placido and Scheimpflug based devices (EyeSys 2000; EyeSys Laboratories, Houston, TX, and Pentacam HR; Oculus Optikgeräte GmbH, Wetzlar, Germany). METHODS This prospective study involved 20 healthy volunteers (20 eyes) recruited from the staff of the Antwerp University Hospital. For each eye, three measurements were taken using each device, from which eight parameters describing keratometry and astigmatism were derived. Repeatability was assessed using intrasession, within-subject analysis of variance. Agreement was evaluated between pairs of devices with Bland- Altman plots and 95% confidence intervals. RESULTS The repeatability values were good for all three devices, although slightly worse for the Cassini than for the other two devices for steep, flat, and mean keratometry. The EyeSys showed worse repeatability for the astigmatism axis. EyeSys and Pentacam agreed well with each other in terms of mean keratometry, whereas the Cassini gave consistently higher values by 0.52 diopters (D) when compared with the EyeSys (P < .05, paired t test) and by 0.38 D when compared with the Pentacam (P < .05, paired t test). The Cassini provided similar repeatability values (2.31°) for the astigmatism axis to the Pentacam (2.22°), in contrast to the EyeSys, which produced much more variable axes (9.0°) (P < .05, paired t test). CONCLUSIONS Overall, the three devices display comparable repeatability. The one exception is the astigmatism axis measurement of the EyeSys. The Cassini provides higher keratometry values than the other two devices, but the astigmatism axis agrees well with that provided by the Pentacam.
Postnatal changes of plasma amino acids in suckling pigs.

Amino acids, ammonia, urea, orotate, and nitrate plus nitrite (stable oxidation products of nitric oxide) were determined in plasma of 1- to 21-d-old suckling pigs. Jugular venous blood samples were obtained from pigs at 1, 3, 7, 14, and 21 d of age for analysis of plasma amino acids and metabolites by HPLC and enzymatic methods. Plasma concentrations of arginine and its immediate precursors (citrulline and ornithine) decreased (P < 0.01) progressively (20 to 41%) with increasing age from 3 to 14 d. Plasma concentrations of glutamine declined (P < 0.01) progressively (10 to 31%) during the 1st wk of life. Plasma concentrations of branched-chain amino acids, threonine, and alanine decreased (P < 0.01) (5 to 12%) in 14- and 21-d-old pigs, compared with 1- and 3-d-old pigs. There were no postnatal changes (P > 0.05) in plasma concentrations of other amino acids. Plasma concentrations of ammonia increased (P < 0.01) by 18 and 46%, whereas those of nitrate plus nitrite decreased (P < 0.01) by 16 and 29%, in 7- and 14-d-old pigs, respectively, compared with 1- to 3-d-old pigs. Because arginine plays a crucial role in ammonia detoxification via the hepatic urea cycle and is the physiological substrate for nitric oxide synthesis, our results of the decreased plasma concentrations of arginine and nitrate plus nitrite, as well as the increased plasma ammonia concentration, indicate a hitherto unrecognized deficiency of arginine in 7- to 21-d-old suckling pigs. Arginine is an essential amino acid for piglets and has a great potential to enhance neonatal growth; therefore, further studies are necessary to elucidate the mechanism responsible for arginine deficiency in sow-reared piglets and to identify hormonal and metabolic means for improving neonatal arginine nutrition and growth.
Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion

Both commensal and pathogenic microbes that colonize the GI tract can synthesize and secrete spingomyelinase enzymes that cleave membrane sphingomyelin, leaving the ceramide component intact in the cell membrane. This study examines how this reaction affects the structure and function of host enterocytes and mucosal defense.
A Three-Dimensional Skeletal Reconstruction of the Stem Amniote Orobates pabsti (Diadectidae): Analyses of Body Mass, Centre of Mass Position, and Joint Mobility

Orobates pabsti, a basal diadectid from the lower Permian, is a key fossil for the understanding of early amniote evolution. Quantitative analysis of anatomical information suffers from fragmentation of fossil bones, plastic deformation due to diagenetic processes and fragile preservation within surrounding rock matrix, preventing further biomechanical investigation. Here we describe the steps taken to digitally reconstruct MNG 10181, the holotype specimen of Orobates pabsti, and subsequently use the digital reconstruction to assess body mass, position of the centre of mass in individual segments as well as the whole animal, and study joint mobility in the shoulder and hip joints. The shape of most fossil bone fragments could be recovered from micro-focus computed tomography scans. This also revealed structures that were hitherto hidden within the rock matrix. However, parts of the axial skeleton had to be modelled using relevant isolated bones from the same locality as templates. Based on the digital fossil, mass of MNG 10181 was estimated using a model of body shape that was varied within a plausible range to account for uncertainties of the dimension. In the mean estimate model the specimen had an estimated mass of circa 4 kg. Varying of the mass distribution amongst body segments further revealed that Orobates carried most of its weight on the hind limbs. Mostly unrestricted joint morphology further suggested that MNG 10181 was able to effectively generate propulsion with the pelvic limbs. The digital reconstruction is made available for future biomechanical studies.
Classification of students' performance in computer programming course according to learning style

In Information Technology related programs, computer programming courses are made compulsory subjects in most institutions of learning. However there are many reports on poor performance among students in such courses. Previous studies examined some of the variables influencing students' performance using statistical data analysis. The critical point of this study is the use of classification algorithm to extract patterns which are examined from the cognitive factor specific learning style. The findings show that that student's good performance in programming courses has a visual, active and sequential learning style.
Statistical determinants of dendritic morphology in hippocampal pyramidal neurons: A hidden Markov model

Dendritic structure is traditionally characterized by distributions and interrelations of morphometric parameters, such as Sholl‐like plots of the number of branches versus dendritic path distance. However, how much of a given morphology is effectively captured by any statistical description is generally unknown. In this work, we assemble a small number of standard geometrical parameters measured from experimental data in a simple stochastic algorithm to describe the dendrograms of hippocampal pyramidal cells. The model, consistent with the hidden Markov framework, is feedforward, local, and causal. It relies on two “hidden” local variables: the expected number of terminal tips in a given subtree, and the current path distance from the soma. The algorithm generates dendrograms that statistically reproduce all morphological essentials of dendrites observed in real neurons, including the distributions of branching and termination points, branch lengths, membrane area, topological asymmetry, and (assuming passive membrane parameters within physiological range) electrotonic characteristics. Thus, this algorithm and the small number of its morphometric parameters constitute a remarkably complete description of the dendrograms of hippocampal pyramidal cells. Specifically, it is found that CA3 and CA1 basal dendrites and CA3 apical dendrites can each be described as homogeneous morphological classes. In contrast, the accurate generation of CA1 apical dendrites necessitates the separate sampling of two types of branches, main and oblique, suggesting their derivations from different developmental mechanisms (terminal and interstitial growth, respectively). We further offer a plausible biophysical interpretation of the model hidden variables, relating them to microtubules and other intracellular resources. © 2004 Wiley‐Liss, Inc.
Software Reliability Prediction and Assessment Using both Finite and Infinite Server Queueing Approaches

Over the past 30 years, many software reliability growth models (SRGMs) have been proposed for estimation of reliability growth of software. In fact, effective debugging is not easy because the fault may not be immediately obvious. In the past, some researchers ever used an infinite server queueing (ISO) model to describe the software debugging behavior. An infinite-server queueing model is considered where access of customers to service is controlled by a gate and the gate is open only if all servers are free. However, the finite server queueing (FSQ) model is first advantageously modeled as an infinite-server system. Thus, in this paper, we show how to incorporate both FSQ and ISQ models into software reliability estimation and prediction. In addition, we also consider the factor of perfect/imperfect debugging. Experimental results show that the proposed framework to incorporate both fault detection and correction processes for SRGM has a fairly accurate prediction capability
Using Self-Organizing Map in Backbone Formation for Wireless Sensor Networks

Backbone formation has been used extensively in various aspects for wireless sensor networks recently. Many methods are mostly designed to minimize the size of the backbone or find small cost path. This paper propose the Artificial Neural Networks Routing (ANNR) algorithm which use self-organizing map to measure the Quality of Service supported by the networks. A method of offline process and online process is discussed to deal with constrains on sensor data computing and power consumption. Experimental results have confirmed the algorithm feasibility and the validity.
Electric current flow in excitable cells

Conduction of Electrical Current to and Through the Human February 6th, 2017 PART A BASICS OF ELECTRICITY AND HOW IT INTERACTS WITH THE HUMAN BODY Electric shock is defined as a sudden violent response to electric current flow through any part of a person s body Electrocution is death caused by electric shock Primary electrical injury is tissue damage produced directly by electrical current or voltage Secondary injuries such as falls are common
Insights into neural stem cell biology from flies

Drosophila neuroblasts are similar to mammalian neural stem cells in their ability to self-renew and to produce many different types of neurons and glial cells. In the past two decades, great advances have been made in understanding the molecular mechanisms underlying embryonic neuroblast formation, the establishment of cell polarity and the temporal regulation of cell fate. It is now a challenge to connect, at the molecular level, the different cell biological events underlying the transition from neural stem cell maintenance to differentiation. Progress has also been made in understanding the later stages of development, when neuroblasts become mitotically inactive, or quiescent, and are then reactivated postembryonically to generate the neurons that make up the adult nervous system. The ability to manipulate the steps leading from quiescence to proliferation and from proliferation to differentiation will have a major impact on the treatment of neurological injury and neurodegenerative disease.
Permeability and drying behavior of Western Hemlock

The permeability of wood is related to its rate of drying from a green condition, in that the greater the permeability, the more rapidly wood dries above the fiber saturation point (Hart, 1964). If this relation is true for western hemlock, one could use permeability of wood as determined in laboratory tests to segregate western hemlock heartwood according to its drying rate, because permeability of wood can be determined easily. Moreover, evaluation of permeability also will help us to understand better the drying mechanism of wood above the fiber saturation point.
Narrowband UV-B phototherapy, alefacept, and clearance of psoriasis.

OBJECTIVE To determine whether the addition of 311-nm narrowband UV-B (NB UV-B) phototherapy accelerates and improves the therapeutic efficacy of alefacept, a biological antipsoriatic drug approved for the treatment of moderate to severe psoriasis. DESIGN Randomized half-body comparison study. SETTING Ambulatory section of a university hospital photodermatology unit. PATIENTS Fourteen patients with moderate to severe psoriasis. INTERVENTIONS All patients were treated with 7.5 mg of intravenous alefacept once weekly for 12 weeks. Three times each week, a randomly selected body half (left or right) was treated with NB UV-B light until complete remission, defined as a reduction in the Psoriasis Area Severity Index (PASI) to 3 or lower, was achieved on the irradiated body half. MAIN OUTCOME MEASURES Modified PASI, self-assessed visual analogue scale rating of skin lesions, and self-assessed therapeutic efficacy. RESULTS After 12 weeks of treatment, the mean PASIs on UV-irradiated and nonirradiated body halves were significantly reduced by 81% and 62%, respectively (P < .001). From week 3 to week 12, the mean PASI was significantly lower on UV-irradiated body halves than on nonirradiated body halves (P < .001). At week 12, PASI reductions of greater than 75% had been achieved significantly more often on UV-irradiated body halves (86%, 12 of 14) than on nonirradiated body halves (43%, 6 of 14), and complete remission had been achieved significantly more often on UV-irradiated body halves (43%, 6 of 14) than on nonirradiated body halves (0 of 14) (McNemar test P = .03). CONCLUSIONS In this randomized half-side comparison of alefacept with and without phototherapy for psoriasis, alefacept with NB UV-B phototherapy accelerated and improved the clearance of psoriasis. This suggests a promising future for this combination as antipsoriatic therapy.