Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of process interruption on mechanical properties of material extrusion parts

Purpose This paper aims to identify and quantify the effects of additive manufacturing (AM) process interruption on the tensile strength of material extrusion parts, and to find solutions to mitigate it. Design/methodology/approach Statistical analysis was performed to compare the tensile strength of specimens prepared with different process interruption time durations and different embedding methods. Subsequently, specimens were reheated at the paused layer before resuming, and tensile strengths were analyzed to observe any improvements. Findings Process interruption significantly reduced the tensile strength of printed parts by 48 per cent compared to non-interrupted specimens. Reheating the paused layer immediately before resuming the print improved part strength significantly by 47 per cent compared to regular process interrupted specimens and by 90 per cent compared to specimens with embeds. Practical implications The layer-by-layer deposition of material in AM introduces the capability for in situ embedding of functional components into printed parts. This paper shows that tensile properties are degraded during embedding due to the need for process interruption. These effects can be addressed by reheating the paused layer, providing process guidance for embedding with AM. Originality/value This paper provides an understanding of process interruption and embedding effects on mechanical properties of the parts, and how to improve them. The results from this experimental analysis provide crucial information toward design guidelines for multi-functional AM with embedded components.
Proliferation of Haemopoietic Stem Cells in Vitro

Summary. A liquid culture system for murine haemopoietic cells is described where proliferation of granulocytes (G‐cultures) or mononuclear cells (M‐cultures) can be maintained for many weeks. In M‐cultures there is a rapid loss of spleen colony forming cells (CFUs). Agar colony forming cells (CFUc) are present for 6 weeks, then decline rapidly. Colonies formed from these CFUc contain only large mononuclear cells. In G‐cultures there is proliferation of CFUs, grafts of which (after 7‐9 weeks in culture) protect lethally irradiated mice from haemopoietic death. Similarly, there is proliferation of CFUc, which form colonies in agar consisting of granulocytes, in all stages of differentiation.
Rapid Assessment of Genetic Ancestry in Populations of Unknown Origin by Genome-Wide Genotyping of Pooled Samples

As we move forward from the current generation of genome-wide association (GWA) studies, additional cohorts of different ancestries will be studied to increase power, fine map association signals, and generalize association results to additional populations. Knowledge of genetic ancestry as well as population substructure will become increasingly important for GWA studies in populations of unknown ancestry. Here we propose genotyping pooled DNA samples using genome-wide SNP arrays as a viable option to efficiently and inexpensively estimate admixture proportion and identify ancestry informative markers (AIMs) in populations of unknown origin. We constructed DNA pools from African American, Native Hawaiian, Latina, and Jamaican samples and genotyped them using the Affymetrix 6.0 array. Aided by individual genotype data from the African American cohort, we established quality control filters to remove poorly performing SNPs and estimated allele frequencies for the remaining SNPs in each panel. We then applied a regression-based method to estimate the proportion of admixture in each cohort using the allele frequencies estimated from pooling and populations from the International HapMap Consortium as reference panels, and identified AIMs unique to each population. In this study, we demonstrated that genotyping pooled DNA samples yields estimates of admixture proportion that are both consistent with our knowledge of population history and similar to those obtained by genotyping known AIMs. Furthermore, through validation by individual genotyping, we demonstrated that pooling is quite effective for identifying SNPs with large allele frequency differences (i.e., AIMs) and that these AIMs are able to differentiate two closely related populations (HapMap JPT and CHB).
Three dimensional cyclonic turbulent flow structures at various geometries, inlet-outlet orientations and operating conditions

Flow structure inside a chamber greatly determines the process performances. Therefore, the flow structure inside a chamber are often constructed in such a way as an effort to obtain equipment performances in accordance with the expectations. This study explored flow structure inside several chamber geometries and operating conditions. Three types of chamber, namely; GTC, DTC and TJC were set as the investigated chambers. The Computational Fluid Dynamics technique, supported by some experimental data from the literature, is used as an investigation method. The RANS based models, under Ansys-Fluent software were used in this numerical investigation. Simulation results revealed that the flow structures of GTC and DTC are predominantly created by spiral and vortex patterns. The vortex stabilizer diameter in the GTC affects the vortex pattern, velocity profile and pressure drop. The flow structure of DTC presents the most complex behavior. The flow structure inside TJC, in the case of unconfined outlet boundary, is characterized by the helical and wavy jet pattern. This structure is determined by the initial tangential intensity (IIT) and the inlet aspect ratio (RIA). The structures of vortex, helical, and wavy axial flow are properly constructed and visualized in this paper. There is no a turbulence model which is always superior to the other models, consistently. The standard k-ε model exhibits the realistic and robust performances among all of investigatied cases.
Men and Masculinities in Forensic Psychiatric Care: An Interview Study Concerning Male Nurses' Experiences of Working with Male Caregivers and Male Patients

Forensic psychiatric care is largely populated by men—as patients, caregivers, and nurses. Previous research has not focused on the meaning of gender in this context. The aim of this study is to analyse male nurses' experiences of working with male caregivers and attending to male patients in forensic psychiatric care. Data were collected through interviews with six male nurses. The results consist of five themes. Protection and defence are key aspects of care and male caregivers gain status and authority through their physical strength. This could hamper caring and provide male caregivers with a superior position in the department.
DiGeorge Syndrome Gene tbx1 Functions through wnt11r to Regulate Heart Looping and Differentiation

DiGeorge syndrome (DGS) is the most common microdeletion syndrome, and is characterized by congenital cardiac, craniofacial and immune system abnormalities. The cardiac defects in DGS patients include conotruncal and ventricular septal defects. Although the etiology of DGS is critically regulated by TBX1 gene, the molecular pathways underpinning TBX1's role in heart development are not fully understood. In this study, we characterized heart defects and downstream signaling in the zebrafish tbx1−/− mutant, which has craniofacial and immune defects similar to DGS patients. We show that tbx1−/− mutants have defective heart looping, morphology and function. Defective heart looping is accompanied by failure of cardiomyocytes to differentiate normally and failure to change shape from isotropic to anisotropic morphology in the outer curvatures of the heart. This is the first demonstration of tbx1's role in regulating heart looping, cardiomyocyte shape and differentiation, and may explain how Tbx1 regulates conotruncal development in humans. Next we elucidated tbx1's molecular signaling pathway guided by the cardiac phenotype of tbx1−/− mutants. We show for the first time that wnt11r (wnt11 related), a member of the non-canonical Wnt pathway, and its downstream effector gene alcama (activated leukocyte cell adhesion molecule a) regulate heart looping and differentiation similarly to tbx1. Expression of both wnt11r and alcama are downregulated in tbx1−/− mutants. In addition, both wnt11r −/− mutants and alcama morphants have heart looping and differentiation defects similar to tbx1−/− mutants. Strikingly, heart looping and differentiation in tbx1−/− mutants can be partially rescued by ectopic expression of wnt11r or alcama, supporting a model whereby heart looping and differentiation are regulated by tbx1 in a linear pathway through wnt11r and alcama. This is the first study linking tbx1 and non-canonical Wnt signaling and extends our understanding of DGS and heart development.
Baseline brain activity changes in patients with clinically isolated syndrome revealed by resting-state functional MRI

Background A clinically isolated syndrome (CIS) is the first manifestation of multiple sclerosis (MS). Previous task-related functional MRI studies demonstrate functional reorganization in patients with CIS. Purpose To assess baseline brain activity changes in patients with CIS by using the technique of regional amplitude of low frequency fluctuation (ALFF) as an index in resting-state fMRI. Material and Methods Resting-state fMRIs data acquired from 37 patients with CIS and 37 age- and sex-matched normal controls were compared to investigate ALFF differences. The relationships between ALFF in regions with significant group differences and the EDSS (Expanded Disability Status Scale), disease duration, and T2 lesion volume (T2LV) were further explored. Results Patients with CIS had significantly decreased ALFF in the right anterior cingulate cortex, right caudate, right lingual gyrus, and right cuneus (P < 0.05 corrected for multiple comparisons using Monte Carlo simulation) compared to normal controls, while no significantly increased ALFF were observed in CIS. No significant correlation was found between the EDSS, disease duration, T2LV, and ALFF in regions with significant group differences. Conclusion In patients with CIS, resting-state fMRI demonstrates decreased activity in several brain regions. These results are in contrast to patients with established MS, in whom ALFF demonstrates several regions of increased activity. It is possible that this shift from decreased activity in CIS to increased activity in MS could reflect the dynamics of cortical reorganization.
Correlation between Hypermetabolism and Neuronal Damage during Status Epilepticus Induced by Lithium and Pilocarpine in Immature and Adult Rats

The correlation between seizure-induced hypermetabolism and subsequent neuronal damage was studied in 10-day-old (P10), 21-day-old (P21), and adult rats subjected to lithium-pilocarpine status epilepticus (SE). Local CMRglc (LCMRglc) values were measured by the [14C]2-deoxyglucose method for a duration of 45 minutes starting at 60 minutes after the onset of SE, and neuronal damage was assessed by cresyl violet staining at 6 days after SE. In P21 and adult rats, LCMRglc values were increased by 275 to 875% in all thalamic, cortical, forebrain, and hypothalamic regions plus the substantia nigra. In addition, at P21 there were also large increases in LCMRglc in brainstem regions. In P10 rats, metabolic increases were mostly located in cortical and forebrain regions plus the substantia nigra but did not affect hypothalamic, thalamic, or brainstem areas. In adult rats, there was an anatomical correlation between hypermetabolism and neuronal damage. At P21, although hypermetabolism occurred in regions with damage, the extent of damage varied considerably with the animals and ranged from an almost negligible to a very extended degree. Finally, in P10 rats, although quite pronounced hypermetabolism occurred, there was no neuronal damage induced by the seizures. Thus, in the present model of epilepsy, the correlation between marked hypermetabolism and neuronal damage can be shown in adult rats. Conversely, immature rats can sustain major metabolic activations that lead either to a variable extent of damage, as seen at P21, or no damage, as recorded at P10.
An Industrial Dental-Erosion by Chromic Acid: A Case Report

A case of uncommon occupational dental erosion was reported in an individual who had worked in the war industry for twenty years. This occupation involved daily, at least 8 hours, inhalation of chromic acid being used for cleaning of barrel of cannons. The erosion manifested as dental sensitivity with excessive cervical erosion even with pulpal exposure in certain teeth. Moreover, due to the adverse effect of the chemical against to gingival and/or periodontal tissues, the lesions were extremely harmful with respect to the exposed root-cementum. After proper periodontal therapy, cervical lesions were treated conservatively with a compomer based restorative material without cavity preparation. Although today it is not common due to the well-controlled working conditions, occupational combined dental and medical problems via airborne fumes and/or elements can be seen at workers in chemical factories. A cumulative biohazardous effect is generally seen as not only medical but also dental disorders.
Precise Patterning of Large‐Scale TFT Arrays Based on Solution‐Processed Oxide Semiconductors: A Comparative Study of Additive and Subtractive Approaches

Precise patterning of solution‐processed oxide semiconductors is critical for cost‐effective, large‐scale, and high throughput fabrication of circuits and display application. In this paper, demonstration and comparison are made using the additive and subtractive patterning strategies to precisely fabricate wafer‐scale thin film transistor arrays (1600 devices), which are based on high‐quality solution‐processed indium zinc oxide (IZO) and indium gallium zinc oxide (IGZO). The IZO and IGZO TFTs exhibit field‐effect mobility up to 8.0 and 5.2 cm2 V−1 s−1 when using the additive method, whereas the highest mobility of 24.2 and 13.7 cm2 V−1 s−1 for IZO and IGZO TFTs is achieved when using the subtractive method. The X‐ray photoelectronic spectroscopy studies and quantitative 2D device simulations together reveal that good device performance is attributed to moderate shallow donor‐like states (providing electrons) from oxygen vacancy and few accepter‐like states (trapping electrons) resulted from the dense structural framework of MO bonds. After examining the uniformity and reliability of the devices, the solution‐patterned inverters are demonstrated using negative‐channel metal oxide semiconductors, which show full swing output transfer characteristics and thus provide a promising method for solution‐based fabrications of circuits.
The Bovine ATP-Binding Cassette Transporter ABCG2 Tyr581Ser Single-Nucleotide Polymorphism Increases Milk Secretion of the Fluoroquinolone Danofloxacin

The bovine adenosine triphosphate-binding cassette transporter G2 (ABCG2/breast cancer resistance protein) polymorphism Tyr581Ser (Y581S) has recently been shown to increase in vitro transepithelial transport of antibiotics. Since this transporter has been extensively related to the active secretion of drugs into milk, the potential in vivo effect of this polymorphism on secretion of xenobiotics in livestock could have striking consequences for milk production, the dairy industry, and public health. Our purpose was to study the in vivo effect of this polymorphism on the secretion of danofloxacin, a widely used veterinary antibiotic, into milk. Danofloxacin (1.25 mg/kg) was administered to six Y/Y 581 homozygous and six Y/S 581 heterozygous lactating cows, and plasma and milk samples were collected and analyzed by high-performance liquid chromatography. No differences were found in the pharmacokinetic parameters of danofloxacin in plasma between the two groups of animals. In contrast, Y/S heterozygous cows showed a 2-fold increase in danofloxacin levels in milk. In addition, the pharmacokinetic elimination parameters, mean residence time and elimination half-life, were significantly lower in the milk of the animals carrying the Y/S polymorphism. These in vivo results are in agreement with our previously published in vitro data, which showed a greater capacity of the S581 variant in accumulation assays, and demonstrate, for the first time, an important effect of the Y581S single-nucleotide polymorphism on antibiotic secretion into cow milk. These findings could be extended to other ABCG2 substrates, and may be relevant for the treatment of mastitis and for the design of accurate and novel strategies to handle milk residues.
symSpline: symmetric two-handed spline manipulation

We introduce symSpline: a symmetric, dual-mouse technique for the manipulation of spline curves. In symSpline, two cursors control the positions of the ends of the tangent to an edit point. By moving the tangent with both mice, the tangent and the edit point can be translated while the curvature of the spline is adjusted simultaneously, according to the length and angle of the tangent. We compare the symSpline technique to two asymmetric dual-mouse spline manipulation techniques and to a standard single-mouse technique. In a spline matching experiment, symSpline outperformed the two asymmetric dual-mouse techniques and all three dual-mouse techniques proved to be faster than the single-mouse technique. Additionally, symSpline was the technique most preferred by test participants.
Participative forest in-situ measurements for biomass mapping in satellite images over Durango State, Mexico

Citizen Science, propelled by the growing popularity of smartphones, can provide valuable reference information for remote sensing image analysis. We demonstrate that the Relasphone, a biomass measuring application previously developed and tested in boreal forests of Finland, can be adapted to temperate-cold pine forests in Durango State, Mexico. Relasphone measurements were in good agreement with reference data over 55 plots (R2 = 0.94), and have been used to produce a biomass map over Durango from a Landsat 8 image. The results suggest the Relasphone can be easily deployed in other biomes.
Molecular Descriptors Family on Structure Activity Relationships 6 . Octanol-Water Partition Coefficient of Polychlorinated Biphenyls Lorentz Jäntschi

Octanol-water partition coefficient of two hundred and six polychlorinated biphenyls was model by the use of an original method based on complex information obtained from compounds structure. The regression analysis shows that best results are obtained in four-varied model (r = 0.9168). The prediction ability of the model was studied through leave-one-out analysis (rcv(loo) = 0.9093) and in training and test sets analysis. Modeling the octanolwater partition coefficient of polychlorinated biphenyls by integration of complex structural information provide a stable and performing four-varied model, allowing us to make remarks about relationship between structure of polychlorinated biphenyls and associated octanol-water partition coefficients.
Thoracic Spinal Cord Stimulation Improves Cardiac Contractile Function and Myocardial Oxygen Consumption in a Porcine Model of Ischemic Heart Failure

Thoracic Spinal Cord Stimulation. Background: Prior experimental studies show that thoracic spinal cord stimulation (SCS) improves left ventricular (LV) ejection fraction (LVEF). The mechanism of this improvement in the LV contractile function after SCS and its effects on the myocardial oxygen consumption remains unknown.
Liquidity Transformation in Asset Management: Evidence from the Cash Holdings of Mutual Funds

We study liquidity transformation in mutual funds using a novel data set on their cash holdings. To provide investors with claims that are more liquid than the underlying assets, funds engage in substantial liquidity management. Specifically, they hold substantial amounts of cash, which they use to accommodate inflows and outflows rather than transacting in the underlying portfolio assets. This is particularly true for funds with illiquid assets and at times of low market liquidity. We provide evidence suggesting that mutual funds’ cash holdings are not large enough to fully mitigate price impact externalities created by the liquidity transformation they engage in.
Rapid Suppression of Activated Rac1 by Cadherins and Nectins during De Novo Cell-Cell Adhesion

Cell-cell adhesion in simple epithelia involves the engagement of E-cadherin and nectins, and the reorganization of the actin cytoskeleton and membrane dynamics by Rho GTPases, particularly Rac1. However, it remains unclear whether E-cadherin and nectins up-regulate, maintain or suppress Rac1 activity during cell-cell adhesion. Roles for Rho GTPases are complicated by cell spreading and integrin-based adhesions to the extracellular matrix that occur concurrently with cell-cell adhesion, and which also require Rho GTPases. Here, we designed a simple approach to examine Rac1 activity upon cell-cell adhesion by MDCK epithelial cells, without cell spreading or integrin-based adhesion. Upon initiation of cell-cell contact in 3-D cell aggregates, we observed an initial peak of Rac1 activity that rapidly decreased by ∼66% within 5 minutes, and further decreased to a low baseline level after 30 minutes. Inhibition of E-cadherin engagement with DECMA-1 Fab fragments or competitive binding of soluble E-cadherin, or nectin2alpha extracellular domain completely inhibited Rac1 activity. These results indicate that cadherins and nectins cooperate to induce and then rapidly suppress Rac1 activity during initial cell-cell adhesion, which may be important in inhibiting the migratory cell phenotype and allowing the establishment of initially weak cell-cell adhesions.
Preparation and Chemical Composition of the Cell Walls of Mature Infectious Dense Forms of Meningopneumonitis Organisms

Relatively large-scale production and purification of meningopneumonitis organisms was developed for chemical and immunological studies on cell walls of the infectious dense forms. By disruption of purified organisms with glass beads in a Mickle shaker, highly purified preparations of cell walls were obtained by sucrose density gradient centrifugation, enzyme digestion, and sodium dodecyl sulfate treatment. The dry-weight recovery of purified cell walls from intact organisms was about 13%. When 32P-labeled preparations of cell walls were fractionated into acid-soluble, lipid, ribonucleic acid (RNA), deoxyribonucleic (DNA), and residual fractions, about 80% of the 32P in cell wall preparations was recovered in the phospholipid fraction, which corresponded to about 3% of the total phospholipid in the intact organisms. About 7% of the 32P in purified cell walls was recovered in the RNA and DNA fractions respectively, but this corresponds to only about 0.4% of the 32P found in those fractions in intact organisms. From dry-weight determinations, it was calculated that the purified cell wall preparations contained only 0.6% total nucleic acids, and these are probably not true cell wall constituents. These cell walls contained 70 to 75% protein, corresponding to about 14% of the protein in intact organisms. Amino acid analysis of these protein showed the existence of all common amino acids, glucosamine, and galactosamine. However, no muramic acid was detected by the methods employed.
On the Assessment of Nonlinear Distortion Effects in MIMO-OFDM Systems

Multiple input multiple output (MIMO) schemes combined with orthogonal frequency division multiplexing (OFDM) modulations are widely employed in broadband wireless systems. However, the transmitted signals are prone to nonlinear distortion effects due to their high envelope fluctuations. In this paper, we present a simple analytical method for studying nonlinear effects in MIMO-OFDM systems. Our method allows accurate results for the power spectral density (PSD) of the transmitted signals, as well as the signal- to- interference (SIR) levels at the detection level. It is shown that the robustness to nonlinear distortion effects increases with the number of transmit antennas (for a fixed number of independent data streams).