Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Type and Thickness of Flexible Packaging Films on Perforation by Plodia interpuntella

This study investigated the effect of perforation by the Indian meal moth (Plodia interpunctella) larvae on various flexible food-packaging films, in relation to their thickness and type. Among the various flexible packaging films, polyethylene (PE), aluminum foil (AF), polypropylene (PP), polystyrene (PS), and polyethylene terephthalate (PET) were selected for this study due to their wide usage in food packaging. Based on their thickness, film penetration by P. interpunctella larvae was measured as in following order: PP, ; AF, ; PET, ; PP, ; PS, ; PE, ; PE, ; PS, ; and PET, . P. interpunctella larvae rapidly penetrated through the packaging films regardless of their thickness and type. In particular, it was observed that PP of and PS of were completely penetrated by P. interpunctella larvae within 72 h, rendering thin PP and PS films less valuable as anti-insect packaging films. Our results show that the perforations by P. interpunctella larvae were observed in the thin films. These results imply that each packaging film has a marginal thickness against the perforations by P. interpunctella larvae.
Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the Mayo Clinic Study of Aging

ABSTRACT Background: Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. Methods: We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota; involving CN persons aged ≥ 60 years that underwent PiB-PET scans and completed Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Cognitive diagnosis was made by an expert consensus panel. Participants were classified as having abnormal (≥1.4; PiB+) or normal PiB-PET (<1.4; PiB−) using a global cortical to cerebellar ratio. Multi-variable logistic regression analyses were performed to calculate odds ratios (OR) and 95% confidence intervals (95% CI) after adjusting for age and sex. Results: Of 1,038 CN participants (53.1% males), 379 were PiB+. Each one point symptom increase in the BDI (OR = 1.03; 1.00–1.06) and BAI (OR = 1.04; 1.01–1.08) was associated with increased odds of PiB-PET+. The number of participants with BDI > 13 (clinical depression) was greater in the PiB-PET+ than PiB-PET- group but the difference was not significant (OR = 1.42; 0.83–2.43). Similarly, the number of participants with BAI > 10 (clinical anxiety) was greater in the PiB-PET+ than PiB-PET− group but the difference was not significant (OR = 1.77; 0.97–3.22). Conclusions: As expected, depression and anxiety levels were low in this community-dwelling sample, which likely reduced our statistical power. However, we observed an informative albeit weak association between increased BDI and BAI scores and elevated cortical amyloid deposition. This observation needs to be tested in a longitudinal cohort study.
Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells

The formation of new blood vessels represents a crucial event under both physiological and pathological circumstances. In this study, we evaluated by immunohistochemistry, and/or Western blotting and/or quantitative real time-PCR the expression of HIF1α, HIF2α, VEGF, VEGFR1 and VEGFR2 in surgical glioblastoma multiforme (GBM) and peritumoral tissue samples obtained from 50 patients as well as in cancer stem cells (CSCs) isolated from GBM (GCSCs) and peritumoral tissue (PCSCs) of 5 patients. We also investigated the contribution of both GCSCs and PCSCs on the behavior of endothelial cells (ECs) in vitro. Immunohistochemistry demonstrated the expression of angiogenesis markers in both GBM and peritumoral tissue. In addition, in vitro tube formation assay indicated that both GCSCs and PCSCs stimulate EC proliferation as well as tube-like vessel formation. An increased migration aptitude was mainly observed when ECs were cultured in the presence of GCSCs rather than in the presence of PCSCs. These findings suggest that relevant neoangiogenetic events may occur in GBM. In particular, VEGF/VEGFR co-expression in PCSCs leads to hypothesize the involvement of an autocrine signaling. Moreover, our results suggest that both GCSCs and PCSCs own the skill of activating the “angiogenic switch” and the capability of modulating EC behavior, indicating that both cell types are either responsive to angiogenic stimuli or able to trigger angiogenic response. Together with our previous findings, this study adds a further piece to the challenging puzzle of the characterization of peritumoral tissue and of the definition of its real role in GBM pathophysiology.
Metabolite profiling and enzyme reaction phenotyping of luseogliflozin, a sodium–glucose cotransporter 2 inhibitor, in humans

Abstract 1. To understand the clearance mechanism of luseogliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, we investigated its human metabolite profile and metabolic enzymes responsible for the primary metabolic pathways in human using reaction phenotyping. 2. Sixteen metabolites of luseogliflozin were found in human plasma and/or urine and their structural information indicated that the drug was metabolized via multiple metabolic pathways. The primary metabolic pathways involve (1) O-deethylation to form M2 and subsequent glucuronidation to form M12, (2) ω-hydroxylation at ethoxy group to form M3 followed by oxidation to form the corresponding carboxylic acid metabolite (M17) and (3) direct glucuronidation to form M8. 3. The reaction phenotyping studies indicated that the formation of M2 was mainly mediated by cytochrome P450 (CYP) 3A4/5, and subsequently M12 formation was catalyzed by UGT1A1, UGT1A8 and UGT1A9. The formation of M3 was mediated by CYP4A11, CYP4F2 and CYP4F3B, and the further oxidation of M3 to M17 was mediated by alcohol dehydrogenase and aldehyde dehydrogenase. The formation of M8 was catalyzed by UGT1A1. 4. These results demonstrate that luseogliflozin is metabolized through multiple pathways, including CYP-mediated oxidation and glucuronidation, in human.
Medication Sharing, Storage, and Disposal Practices for Opioid Medications Among US Adults.

Author Contributions: Dr Oramasionwu had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Oramasionwu, Cole, Dunlap, Zule. Acquisition, analysis, or interpretation of data: Oramasionwu, Cole, Dixon, Blalock, Zarkin. Drafting of the manuscript: Oramasionwu, Cole. Critical revision of the manuscript for important intellectual content: Oramasionwu, Cole, Dixon, Blalock, Zarkin, Dunlap, Zule. Statistical analysis: Oramasionwu, Cole, Dixon, Blalock. Obtained funding: Oramasionwu. Administrative, technical, or material support: Oramasionwu, Zarkin. Study supervision: Oramasionwu. Review of analytic output/results: Dunlap.
On the plasma chemistry of a cold atmospheric argon plasma jet with shielding gas device

A novel approach combining experimental and numerical methods for the study of reaction mechanisms in a cold atmospheric Ar ? > plasma jet is introduced. The jet is operated with a shielding gas device that produces a gas curtain of defined composition around the plasma plume. The shielding gas composition is varied from pure N2 ? > to pure O2 ? >. The density of metastable argon Ar(4s,3P2) ? > in the plasma plume was quantified using laser atom absorption spectroscopy. The density of long-living reactive oxygen and nitrogen species (RONS), namely O3 ? >, NO2 ? >, NO ? >, N2O ? >, N2O5 ? > and H2O2 ? >, was quantified in the downstream region of the jet in a multipass cell using Fourier-transform infrared spectroscopy (FTIR). The jet produces a turbulent flow field and features guided streamers propagating at several km s−1 ? > that follow the chaotic argon flow pattern, yielding a plasma plume with steep spatial gradients and a time dependence on the ns ? > scale while the downstream chemistry unfolds within several seconds. The fast and highly localized electron impact reactions in the guided streamer head and the slower gas phase reactions of neutrals occurring in the plasma plume and experimental apparatus are therefore represented in two separate kinetic models. The first electron impact reaction kinetics model is correlated to the LAAS measurements and shows that in the guided streamer head primary reactive oxygen and nitrogen species are dominantly generated from Ar(4s,3P2) ? >. The second neutral species plug-flow model hence uses an Ar(4s,3P2) ? > source term as sole energy input and yields good agreement with the RONS measured by FTIR spectroscopy.
Avoiding alert fatigue in pulmonary embolism decision support: a new method to examine ‘trigger rates’

A clinical decision support system (CDSS) is integrated into the electronic health record (EHR) and allows physicians to easily use a clinical decision support (CDS) tool. However, often CDSSs are integrated into the EHR with poor adoption rates. One reason for this is secondary to ‘trigger fatigue’. Therefore, we developed a new and innovative usability process named ‘sensitivity and specificity trigger analysis’ (SSTA) as part of our larger project around a pulmonary embolism decision support tool. SSTA will enable programmers to examine optimal trigger rates prior to the integration of a CDS tool into the EHR, by using a formal method of analysis. We performed a retrospective chart review. The outcome of interest was physician ordering of a CT angiography (CTA). Phrases that signify common symptoms associated with pulmonary embolism were assessed as possible triggers for the CDSS tool. We then analysed each trigger's ability to predict physician ordering of a CTA. We found that the most sensitive way to trigger the Pulmonary Embolism CDS tool while still maintaining a high specificity was by combining 1 or more pertinent symptoms with 1 or more elements of the Wells criteria. This study explored a unique methodology, SSTA, used to limit inaccurate triggering of a CDS tool prior to integration into the EHR. This methodology can be applied to other studies aiming to decrease triggering rates and increase adoption rates of previously validated CDSS tools.
Knowledge of Palliative Care Among Community-Dwelling Adults

Objective: To identify what laypersons know about palliative care using the Palliative Care Knowledge Scale (PaCKS). A secondary aim was to establish preliminary normative data for the PaCKS. Methods: A sample of 301 adults were recruited via Amazon’s Mechanical Turk database. Participants were administered the PaCKS along with a demographic questionnaire. Results: The mean score on the 13-item PaCKS was 5.25 (standard deviation = 4.77, range: 0-13), the median was 5, and the mode was 0, with a significant proportion of participants selecting “I don’t know” for every item. Women scored significantly higher than men, and 45- to 54- and 55- to 64-year-olds scoring highest. The PaCKS was also significantly positively correlated with education. Conclusion: Broadly, laypersons lack knowledge about some key aspects of palliative care, though palliative care knowledge is highly variable across individuals and some groups. Targeted educational interventions are essential to improve knowledge of palliative care in order to increase access to this type of life-enhancing, supportive service.
Modified Moral Distress Scale (MDS-11): Validation Study Among Italian Nurses.

BACKGROUND Moral distress (MD) has significant implications on individual and organizational health. However there is a lack of an instrument to assess it among Italian nurses. AIM The main aim of this study was to validate a brief instrument to assess MD, developed from the Corley's Moral Distress Scale (MDS). METHOD The modified MDS scale was subjected to content and cultural validity. The scale was administered to 347 nurses. Psychometric analysis were performed to assess construct validity. RESULTS The scale consists of 11 items, investigating MD in nursing practice in different clinical settings. The dimensionality of the scale was investigated through exploratory factor analysis (EFA), which showed a two-dimensional structure labeled futility and potential damage. The futility refers to feelings of powerlessness and ineffectiveness in some clinical situations; the potential damage dimension captures feelings of powerlessness when nurses are forced to tolerate or perform perceived abusive clinical proceedings. Nurses who experienced higher MD, were more lilely to experience burnout. CONCLUSIONS The modified MDS showed good psychometric properties, and it is valid and reliable for assessing moral distress among Italian nurses. Hence, the modified MDS allows to monitor the distress experienced by nurses and it is an important contribution to the scientific community and all those dealing with well-being of health workers.
Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork

Purpose To determine if proteasome inhibition using MG132 increased the efficiency of FIV vector–mediated transduction in human trabecular meshwork (TM)-1 cells and monkey organ-cultured anterior segments (MOCAS). Methods TM-1 cells were pretreated for 1 hour with 0.5% dimethyl sulfoxide (DMSO; vehicle control) or 5 to 50 μM MG132 and transduced with FIV.GFP (green fluorescent protein)– or FIV.mCherry-expressing vector at a multiplicity of transduction (MOT) of 20. At 24 hours, cells were fixed and stained with antibodies for GFP, and positive cells were counted, manually or by fluorescence-activated cell sorting (FACS). Cells transduced with FIV.GFP particles alone were used as controls. The effect of 20 μM MG132 treatment on high- and low-dose (2 × 107 and 0.8 × 107 transducing units [TU], respectively) FIV.GFP transduction with or without MG132 was also evaluated in MOCAS using fluorescence microscopy. Vector genome equivalents in cells and tissues were quantified by quantitative (q)PCR on DNA. Results In the MG132 treatment groups, there was a significant dose-dependent increase in the percentage of transduced cells at all concentrations tested. Vector genome equivalents were also increased in TM-1 cells treated with MG132. Increased FIV.GFP expression in the TM was also observed in MOCAS treated with 20 μM MG132 and the high dose of vector. Vector genome equivalents were also significantly increased in the MOCAS tissues. Increased transduction was not seen with the low dose of virus. Conclusions Proteasome inhibition increased the transduction efficiency of FIV particles in TM-1 cells and MOCAS and may be a useful adjunct for delivery of therapeutic genes to the TM by lentiviral vectors.
Absence of myeloid Klf4 reduces prostate cancer growth with pro-atherosclerotic activation of tumor myeloid cells and infiltration of CD8 T cells

The microenvironment of prostate cancer often includes abundant tumor-associated macrophages (TAMs), with their acquisition of an M2 phenotype correlating with local aggressiveness and metastasis. Tumor-derived M-CSF contributes to TAM M2 polarization, and M-CSF receptor inhibition slows prostate cancer growth in model systems. As additional cytokines can direct TAM M2 polarization, targeting downstream transcription factors could avoid resistance. Klf4 and C/EBPβ each contribute to monocyte development, and reduced expression of macrophage Klf4 or C/EBPβ favors their adoption of a pro-inflammatory M1 state. We find that a Hi-Myc C57BL/6 prostate cancer line grows more slowly in syngeneic Klf4(f/f);Lys-Cre compared with Klf4(f/f) mice when inoculated subcutaneously, but grows equally rapidly in C/EBPβ(f/f);Lys-Cre and C/EBPβ(f/f) hosts. In the absence of myeloid Klf4, TAMs have reduced expression of surface mannose receptor and Fizz1 mRNA, both M2 markers. Global gene expression analysis further revealed activation of pro-inflammatory, pro-atherosclerotic pathways. Analysis of tumor-infiltrating lymphocytes (TILs) demonstrated markedly increased activated CD8 T cell numbers, and CD8 T cell depletion obviated the inhibitory effect of myeloid Klf4 deletion on prostate cancer growth. These findings suggest that reducing expression or activity of the Klf4 transcription factor in tumor myeloid cells may contribute to prostate cancer therapy.
Photoimageable thick-film millimetre-wave metal-pipe rectangular waveguides

A novel dielectric-filled metal-pipe rectangular waveguide has been fabricated using photoimageable thick-film materials. The waveguides incorporate a new transition from CPW-to-TFMS-to-MPRWG. Standard on-wafer measurement techniques, waveguide STD calibration standards, demonstrated low attenuation across the 60 to 90 GHz frequency range.
The absence of crossovers on chromosome 4 in Drosophila melanogaster: Imperfection or interesting exception?

ABSTRACT Drosophila melanogaster chromosome 4 is an anomaly because of its small size, chromatin structure, and most notably its lack of crossing over during meiosis. Earlier ideas about the absence of crossovers on 4 hypothesize that these unique characteristics function to prevent crossovers. Here, we explore hypotheses about the absence of crossovers on 4, how these have been addressed, and new insights into the mechanism behind this suppression. We review recently published results that indicate that global crossover patterning, in particular the centromere effect, make a major contribution to the prevention of crossovers on 4.
Influence and prediction of processing parameters on the properties of microcellular injection molded thermoplastic polyurethane based on an orthogonal array test

Thermoplastic polyurethane is a commonly used polymer in our daily lives. Microcellular injection molding (a.k.a. MuCell) is an emerging method capable of mass-producing thermoplastic polyurethane foams with tunable microstructures and properties. This study investigated the effects of four main processing parameters—namely, plasticizing temperature, carbon dioxide (CO2) content, injection volume, and injection speed—on microcellular injection molded thermoplastic polyurethane ASTM tensile test bars. Property variables of interest included the cell diameter, cell density, skin layer thickness, and Young’s modulus. Influence sequences of parameters on each variable were obtained via the orthogonal array test method. It was found that the CO2 content primarily affected the cell diameter and cell density, whereas the temperature mainly influenced the skin layer thickness and Young’s modulus. Surface fitting of each dependent variable was done by combining its two most influential parameters from the experiment data. The value of each property variable within the processing window could then be predicted from the fitted surface. In addition, microcellular injection molding of thermoplastic polyurethane was simulated by a commercial software package, and the simulated results confirmed the reliability of the cell diameter prediction.
Application of Graphene Gas Sensors in Online Monitoring of SF6 Insulated Equipment

Graphene is an allotrope of carbon apart from graphite, diamond, fullerene and carbon nanotubes. Because graphene has unique mechanical, structural, thermal and electrochemical properties and can present the stability characteristics of these features, it becomes two-dimensional (2-d) materials which can alter three-dimensional (3-d) carbon nanotubes composite materials and has important research value. Pristine graphene and graphene films doped with Au nanoparticles were synthesized by the chemical reduction method. Their corresponding gas sensors were both fabricated by the tradi- tional drop coating method and then used as an adsorbent for the detection of H 2 S, SO 2 , SOF 2 and SO 2 F 2 at room temperature. Theoretical simulation was also investigated when the decomposed gaseous components of sulfur hexafluoride (SF 6 ), namely, H 2 S, SO 2 , SOF 2 and SO 2 F 2 , were adsorbed on pristine and Au-embedded graphene based on DFT. In order to interpret the adsorption processes between Au-doped graphene and gas molecules, this chapter discussed the charge transfer mechanism on the adsorption surface for further investigation.
Chalcogenide Photovoltaics: Physics, Technologies, and Thin Film Devices

Preface Symbols and Acronyms INTRODUCTION History of Cu(In,Ga)(S,Se), Solar Cells History of CdTe Solar Cells Prospects of Chalcogenide Photovoltaics THIN FILM HETEROSTRUCTURES Energies and Potentials Charge Densities and Fluxes Energy Band Diagrams Diode Currents Light Generated Currents Device Analysis and Parameters DESIGN RULES FOR HETEROSTRUCTURE SOLAR CELLS AND MODULES Absorber Bandgap Band Alignment Emitter Doping and Doping Ratio Fermi Level Pinning Absorber Doping Absorber Thickness Grain Boundaries Back Contact Barrier Buffer Thickness Front Surface Gradient Back Surface Gradients Monolithic Series Interconnection THIN FILM MATERIAL PROPERTIES AII-BVI Absorbers AI-BIII-C2VI Absorbers Buffer Layers Window Layers Interfaces THIN FILM TECHNOLOGY CdTe Cells and Modules Cu(In,Ga)(S,Se)2 Cells and Modules PHOTOVOLTAIC PROPERTIES OF STANDARD DEVICES CdTe Device Properties AI-BIII-C2VI Device Properties APPENDIX A: FREQUENTLY OBSERVED ANOMALIES JV Curves Colar Cell Parameters Diode Parameters Quantum Efficiency Transient Effects APPENDIX B: TABLES
The role of T790M mutation in EGFR-TKI re-challenge for patients with EGFR-mutant advanced lung adenocarcinoma

Epidermal growth factor receptor (EGFR) T790M mutation has shown to be associated with the clinical outcomes of patients after initial EGFR-tyrosine kinase inhibitor (EGFR-TKI) therapy in EGFR-mutant advanced non-small cell lung cancer (NSCLC). However, its predictive role in EGFR-TKI re-challenge remains unknown. The present study was aimed to explore the correlation between T790M mutation and any benefits from EGFR-TKI re-challenge. We retrospectively reviewed 922 consecutive patients with EGFR-mutant non-small cell lung cancer (NSCLC) patients administered with gefitinib/erlotinib at Guangdong General Hospital. Progression-free survival (PFS), overall survival (OS), objective response rate (ORR) and disease control rate (DCR) were analyzed respectively. In total, 66 EGFR-mutant patients with stage IV adenocarcinoma were eligible, of whom 51 underwent re-biopsy upon initial progression. Among them, 18 (35.3%) harbored T790M mutation. No statistical significant differences were seen between T790M-positive and T790M-negative patients in PFS, OS, ORR or DCR. The median PFS, median OS, ORR, and DCR of the overall 66 patients were 2.0 months, 6.8 months, 6.1% and 39.4%, respectively. Good performance status (PS) was found to be independent favorable prognostic factor and long TKI-free interval to be associated with superior PFS. In conclusion, T790M mutation might not predict the clinical outcomes in first-generation EGFR-TKI re-challenge. Based on the poor efficacy from our data, re-challenge of first-generation EGFR-TKIs could not be recommended routinely, but for those with good PS and long TKI-free interval, it might be an alternative option.