Miracle-dz/UniFAR-FTUs huggingface dataset:
Screw elastic intramedullary nail for the management of adult forearm fractures

Background: The failure of the conventional nailing of both forearm bones or isolated fractures of radius and ulna pose a potential problem of nail migration and rotational instability, despite the best reduction. The purpose of this paper is to evaluate the results of screw elastic intramedullary nail for the treatment of adult diaphyseal fractures of both forearm bones, which effectively addresses the problems associated with the conventional nailing systems for the forearm fractures. Materials and Methods: Seventy-six adults with forearm fractures (radius and ulna or isolated fracture of the single bone) were retrospectively evaluated. Fifty males and 26 females with the mean age of 38 years (range, 18–70 years) underwent closed reduction and screw intramedullary nail fixation. Ten patients required limited open reduction. The fractures were classified according to the AO/OTA system. The average followup was 12 months (range, 6 to 18 months). Results: The mean surgical time was 45 minutes (35 to 65 minutes). The meantime to union was 14 weeks (10-21 weeks). The results were graded as excellent in 50, good in 18 patients, and acceptable in eight patients, using the criteria of Grace and Eversman. We had superficial infection in three cases, one case of delayed infection, painful bursa in two cases, delayed union in two cases, malunion with dislocation of the DRUJ in two cases, injury to the extensor tendon of the thumb in one case, and one case of incomplete radioulnar synostosis. Conclusion: Closed reduction and internal fixation of forearm fractures by screw intramedullary nails reestablishes the near normal relationship of the fractured fragments. Screw intramedullary nail effectively controls both rotatory forces and the migration of the nail. It produces excellent clinical results in isolated fractures of either bones, as well as both bones of the forearm in adults.
Surface Mapping of Motor Points in Biceps Brachii Muscle

Objective To localize the site of motor points within human biceps brachii muscles through surface mapping using electrophysiological method. Method We recorded the compound muscle action potentials of each lattice of the biceps brachii in 40 healthy subjects. Standardized reference lines were made as the following: 1) a horizontal reference line (elbow crease) and 2) a vertical reference line connecting coracoid process and mid-point of the horizontal reference line. The Compound muscle action potentials were mapped in reference to the standardized reference lines. The locations of motor points were mapped to the skin surface, in the ratio to the length of the vertical and the half of the horizontal reference lines. Results The motor point of the short head of biceps was located at 69.0±4.9% distal and 19.1±9.5% medial to the mid-point of horizontal reference line. The location of the motor point of the long head of the biceps was 67.3±4.3% distal and 21.4±8.7% lateral. The motor point of the short head of the biceps was located more medially and distally in the male subjects compared to that in the female (p<0.05). Conclusion This study showed electrophysiological motor points of the biceps brachii muscles through surface mapping. This data might improve the clinical efficacy and the feasibility of motor point targeting, when injecting botulinum neurotoxin in biceps brachii.
Does Mother's Smoking Influence Girls’ Smoking More Than Boys’ Smoking? A 20-Year Review of the Literature Using a Sex- and Gender-Based Analysis

A systematic literature review was conducted to examine whether mother's smoking influences girls’ smoking more than boys’ smoking. Fifty-seven studies, published between 1989 and 2009, were analyzed using a sex and gender lens. Results indicate that mother's prenatal and postnatal smoking influences girls’ smoking more than boys’ smoking. Despite evidence that sex and gender are important determinants of smoking among adolescents when examined in relation to mother's smoking, the theoretical understanding of why girls are more likely to smoke if prenatally and postnatally exposed to mother's smoking remains unclear. Implications for future research are discussed.
Maternal occupational exposure to solvents and congenital malformations: a prospective study in the general population

Objective: To study the relations between maternal occupational exposure to solvents during pregnancy and the risk of congenital malformations. Methods: A prospective population-based cohort, specifically designed to study the impact of maternal exposure to solvents on the risk of congenital malformations, began in 2002 in three districts of Brittany (France). 3421 pregnant women were recruited until the end of 2005 by physicians before 19 weeks of gestation and followed through birth. Information on pregnancy outcomes was obtained from the hospital. Occupational exposure to solvents at the beginning of pregnancy was assessed from the women’s self-reported occupational exposures at inclusion and from a job-exposure matrix (JEM). Sociodemographic characteristics, lifestyle factors, medical history, diseases during pregnancy were obtained at inclusion and from hospital records. Analyses were restricted to working women (n = 3005). Logistic regressions were used to adjust for potential confounders. Results: 30.2% of the working women declared regular exposure to at least one product that may contain solvents. 21.3% of them were classified at least in the medium exposure category using the JEM. Occupations mainly classified as exposed by both assessment methods were hairdressers, nurses’ aides, nurses and chemists/biologists. Significant associations were found between major congenital malformations and maternal occupational exposure to solvents, assessed by both self-report odds ratio (OR = 2.48, 95% CI 1.4 to 4.4 for regular exposure vs no exposure) and the JEM (OR = 3.48, 95% CI 1.4 to 8.4 for highest level of exposure vs no exposure). A significant dose–response trend was observed with both assessment methods. Several subgroups of major malformations were associated with maternal exposure to solvents (oral clefts, urinary malformations and male genital malformations). Conclusion: This study provides further evidence of an association between exposure to solvents during pregnancy and the risk of major malformations.
Effect of methanolic fraction of Kalanchoe crenata on metabolic parameters in adriamycin-induced renal impairment in rats

Objectives: To investigate the effect of Kalanchoe crenata methanolic fraction (MEKC) on proteinuria, glucosuria, and some other biochemical parameters in adriamycin-induced renal impairment in rats. Materials and Methods: Ether anesthetized rats received three intravenous injections (days 0, 14, and 28) of 2 mg/kg body weight of adriamycin. Repeated doses of the extract (0, 50, and 68 mg/kg b.w.) and losartan (10 mg/kg b.w.) were administered orally once daily, for 6 weeks, to these rats. Kidney functions were assessed through biochemical parameters. Results: MEKC decreased proteinuria and also the urinary excretion of creatinine, glucose, and urea significantly in diseased rats. A decrease in serum levels of creatinine, urea, potassium, alkaline phosphatase, conjugate bilirubin, and alanine transaminase level was also recorded in nephropathic rats, but plasma levels of uric acid and glucose remained unchanged. Moreover, the plant extract markedly (P < 0.05) increased plasma sodium and decreased (P < 0.01) the urinary sodium and potassium levels. Conclusions: The results indicated that the treatment with the methanolic fraction of K. crenata may improve proteinuria and all other symptoms due to adriamycin-induced nephropathy and, more than losartan, could ameliorate kidney and liver functions. K. crenata could be a potential source of new oral antinephropathic drug.
IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction

Significance Coronary heart disease is a leading cause of death worldwide. After acute myocardial infarction, early reperfusion limits infarct progression and improves clinical outcomes. However, despite reperfusion, the incidence of heart failure and cardiovascular deaths remains unacceptably high. Here, we report that a few days after ischemia, the reperfused heart transiently elaborates the cardioprotective polypeptide, insulin-like growth factor-1 (IGF-1). However, tissue IGF-1 levels increase only transiently because it is rapidly degraded by the chymase, mouse mast cell protease 4. Mouse mast cell protease 4 deletion promotes cardiac cell survival by reducing IGF-1 degradation, which ameliorates cardiac dysfunction caused by ischemic injury. Our findings suggest that chymase inhibition may be a viable therapeutic approach to enhance late cardioprotection in postischemic heart disease. Heart disease is a leading cause of death in adults. Here, we show that a few days after coronary artery ligation and reperfusion, the ischemia-injured heart elaborates the cardioprotective polypeptide, insulin-like growth factor-1 (IGF-1), which activates IGF-1 receptor prosurvival signaling and improves cardiac left ventricular systolic function. However, this signaling is antagonized by the chymase, mouse mast cell protease 4 (MMCP-4), which degrades IGF-1. We found that deletion of the gene encoding MMCP-4 (Mcpt4), markedly reduced late, but not early, infarct size by suppressing IGF-1 degradation and, consequently, diminished cardiac dysfunction and adverse structural remodeling. Our findings represent the first demonstration to our knowledge of tissue IGF-1 regulation through proteolytic degradation and suggest that chymase inhibition may be a viable therapeutic approach to enhance late cardioprotection in postischemic heart disease.
Impact of the Shift to Neonatal Noninvasive Ventilation in Poland: A Population Study

Objective: This study was undertaken to document the real impact of a directed shift in the standard of neonatal practice to a pervasive use of noninvasive respiratory support. Design: Before-after observational study. Setting: All 18 neonatal ICUs in the capital region of Poland. Patients: Every infant admitted to a neonatal ICU who received respiratory pressure support over a 7-year period of interest (12-month transition to the new noninvasive standard and 36 months before and after). Intervention: Education as to the benefits of noninvasive respiratory support and widespread availability of Infant Flow noninvasive ventilation systems. Measurements and Main Results: Five thousand five hundred fifty-one infants required respiratory support in this period. Of these, 14% were less than 28 weeks estimated gestational age, 33% between 28 and 32 weeks, 31% between 33 and 36 weeks, and 22% more than 36 weeks. The use of noninvasive support, as the first form of respiratory support, increased by 19% (p < 0.001). The use of noninvasive support, for weaning following extubation, increased by 32% (p = 0.06). The increased use in weaning was the most pronounced in infants younger than or equal to 32 weeks estimated gestational age (p < 0.001). There were two prospective primary endpoints, mortality and bad outcome among survivors younger than or equal to 32 weeks estimated gestational age. Mortality decreased from 11% to 7%, and the difference remained statistically significant after controlling for baseline factors (p < 0.001). The reduced mortality was more apparent in infants younger than or equal to 32 weeks estimated gestational age. In infants younger than or equal to 32 weeks estimated gestational age, bad outcome in survivors (grade III bronchopulmonary dyplasia and retinopathy of prematurity requiring laser treatment) did not increase (p = 0.669) after controlling for significant baseline variables. Conclusions: We believe that the adoption of an approach emphasizing noninvasive ventilation in Poland resulted in decreased mortality without an increase in significant pulmonary or retinal morbidity.
Detection of Ehrlichia platys DNA in Brown Dog Ticks (Rhipicephalus sanguineus) in Okinawa Island, Japan

ABSTRACT Thirty-two Rhipicephalus sanguineus females collected from eight free-roaming dogs in Okinawa Island, Japan, were examined for ehrlichial DNA by 16S rRNA-based PCR and subsequent sequencing. Partial sequences of Ehrlichia platys 16S rRNA (678 to 679 bp) were detected in three ticks (9.4%) from two dogs. This is the first report of detection of E. platys in Japan, and also the first report of detection in ticks.
Thermal expansion evolution of metastable β Ti-15Mo alloy during linear heating

Thermal expansion measurement was employed for characterization of phase transformations occurring in metastable β titanium alloy (Ti-15Mo) during linear heating with three different heating rates. Effects of the transformations on materials dimensions is discussed and compared with changes of lattice parameters of present phases obtained from in-situ powder neutron diffraction. The shrinkage of the material with increasing temperature at about 300 °C was attributed to the decrease of lattice parameter of β phase, which occurs due to diffusion of alloying elements out of ω phase. Complete dissolution of ω phase was detected at 560 °C regardless of the heating rate.
Factors Associated With Interest in Receiving Help for Mental Health Problems in Combat Veterans Returning From Deployment to Iraq

Abstract Mental health problems in service members often go untreated. This study focused on factors related to interest in receiving help in a survey sample of 577 combat veterans who were screened positive for posttraumatic stress disorder, depression, or generalized anxiety disorder 3 months after returning from Iraq. Over three quarters of respondents recognized that they had a current problem, but only 40% were interested in receiving help. Interest in receiving help was associated with recognizing a problem and receiving mental health services in the past year. More negative attitudes toward mental health care were associated with lower interest in receiving help; paradoxically, more negative perceptions of unit stigma were associated with increased interest in receiving help. Further studies are needed to better define the relationship between stigma perceptions, interest in receiving care, and actual care utilization and to determine whether attitudes toward mental health care can be modified through changes in how care is delivered. Attitudes toward mental health care should be considered in treatment interventions.
Plant traits and decomposition: are the relationships for roots comparable to those for leaves?

BACKGROUND AND AIMS Fine root decomposition is an important determinant of nutrient and carbon cycling in grasslands; however, little is known about the factors controlling root decomposition among species. Our aim was to investigate whether interspecific variation in the potential decomposition rate of fine roots could be accounted for by root chemical and morphological traits, life history and taxonomic affiliation. We also investigated the co-ordinated variation in root and leaf traits and potential decomposition rates. METHODS We analysed potential decomposition rates and the chemical and morphological traits of fine roots on 18 Mediterranean herbaceous species grown in controlled conditions. The results were compared with those obtained for leaves in a previous study conducted on similar species. KEY RESULTS Differences in the potential decomposition rates of fine roots between species were accounted for by root chemical composition, but not by morphological traits. The root potential decomposition rate varied with taxonomy, but not with life history. Poaceae, with high cellulose concentration and low concentrations of soluble compounds and phosphorus, decomposed more slowly than Asteraceae and Fabaceae. Patterns of root traits, including decomposition rate, mirrored those of leaf traits, resulting in a similar species clustering. CONCLUSIONS The highly co-ordinated variation of roots and leaves in terms of traits and potential decomposition rate suggests that changes in the functional composition of communities in response to anthropogenic changes will strongly affect biogeochemical cycles at the ecosystem level.
Titanium surface processing by nanosecond laser radiation

Институт электрофизики и электроэнергетики РАН, Дворцовая наб. 18, 191186 Санкт-Петербург Теоретически и экспериментально продемонстрирована возможность формирования нанорельефа на поверхности титана методом прямого лазерного наноструктурирования. С помощью атомно-силовой микроскопии определены характерные формы и размеры поверхностных наноструктур. Предложена теоретическая модель и произведена оценка характерных параметров наноструктур на поверхности титана.
Dopamine/Tyrosine Hydroxylase Neurons of the Hypothalamic Arcuate Nucleus Release GABA, Communicate with Dopaminergic and Other Arcuate Neurons, and Respond to Dynorphin, Met-Enkephalin, and Oxytocin

We employ transgenic mice with selective expression of tdTomato or cre recombinase together with optogenetics to investigate whether hypothalamic arcuate (ARC) dopamine/tyrosine hydroxylase (TH) neurons interact with other ARC neurons, how they respond to hypothalamic neuropeptides, and to test whether these cells constitute a single homogeneous population. Immunostaining with dopamine and TH antisera was used to corroborate targeted transgene expression. Using whole-cell recording on a large number of neurons (n = 483), two types of neurons with different electrophysiological properties were identified in the dorsomedial ARC where 94% of TH neurons contained immunoreactive dopamine: bursting and nonbursting neurons. In contrast to rat, the regular oscillations of mouse bursting neurons depend on a mechanism involving both T-type calcium and A-type potassium channel activation, but are independent of gap junction coupling. Optogenetic stimulation using cre recombinase-dependent ChIEF-AAV-DJ expressed in ARC TH neurons evoked postsynaptic GABA currents in the majority of neighboring dopamine and nondopamine neurons, suggesting for the first time substantial synaptic projections from ARC TH cells to other ARC neurons. Numerous met-enkephalin (mENK) and dynorphin-immunoreactive boutons appeared to contact ARC TH neurons. mENK inhibited both types of TH neuron through G-protein coupled inwardly rectifying potassium currents mediated by δ and μ opioid receptors. Dynorphin-A inhibited both bursting and nonbursting TH neurons by activating κ receptors. Oxytocin excited both bursting and nonbursting neurons. These results reveal a complexity of TH neurons that communicate extensively with neurons within the ARC. SIGNIFICANCE STATEMENT Here, we show that the great majority of mouse hypothalamic arcuate nucleus (ARC) neurons that synthesize TH in the dorsomedial ARC also contain immunoreactive dopamine, and show either bursting or nonbursting electrical activity. Unlike rats, the mechanism underlying bursting was not dependent on gap junctions but required T-type calcium and A-type potassium channel activation. Neuropeptides dynorphin and met-enkephalin inhibited dopamine neurons, whereas oxytocin excited them. Most ventrolateral ARC TH cells did not contain dopamine and did not show bursting electrical activity. TH-containing neurons appeared to release synaptic GABA within the ARC onto dopamine neurons and unidentified neurons, suggesting that the cells not only control pituitary hormones but also may modulate nearby neurons.
Trust-based RPL for the Internet of Things

The Routing Protocol for Low-Power and Lossy Networks (RPL) is the standardized routing protocol for constrained environments such as 6LoWPAN networks, and is considered as the routing protocol of the Internet of Things (IoT). However, this protocol is subject to several internal and external attacks. In fact, RPL is facing many issues. Among these issues, trust management is a real challenge when deploying RPL. In this paper, we highlight and discuss the different issues of trust management in RPL. We consider that using only TPM (Trust Platform Module) to ensure trustworthiness between nodes is not sufficient. Indeed, an internal infected or selfish node could participate in constructing RPL topology. To overcome this issue, we propose to strengthen RPL by adding a new trustworthiness metric during RPL construction and maintenance. This metric represents the level of trust for each node in the network, and is calculated using selfishness, energy, and honesty components. It allows a node to decide whether or not to trust the other nodes during the construction of the topology.
Effect of W–Mo balance on long-term creep life of 9Cr steel

ABSTRACT The effect of tungsten–molybdenum (W–Mo) balance on creep life has been investigated for five heats of martensitic 9Cr steel with 1.5 % Mo equivalent (= 1/2W + Mo) at 600, 650 and 700°C. The combination of W and Mo concentrations in the present steel is 3W–0Mo, 2.8W–0.1Mo, 2.4W–0.3Mo, 1.8W–0.6Mo and 0W–1.5Mo. The time to rupture tr exhibits a monotonous increase with increasing the W–Mo balance parameter 1/2W/(1/2W + Mo), namely, with increasing W concentration and concomitantly with decreasing Mo. The increase in tr with increasing 1/2W/(1/2W + Mo) becomes less significant at long times. The precipitation of Fe2(W,Mo) Laves phase takes place preferentially at prior austenite grain boundaries during creep, which enhances the grain boundary (GB) precipitation hardening. The amount of Laves phase increases with increasing 1/2W/(1/2W + Mo). The coarsening of Laves phase takes place at long times during creep, which reduces the GB precipitation hardening.
Cryptanalysis of Stream Ciphers Based on Arrays and Modular Addition

In modern cryptography, stream ciphers are most useful in applications where information needs to be encrypted/decrypted at high speed (e.g. high resolution streaming video data) or when low footprint (gates/memory) encryption is required. In the literature, there exist plenty of stream ciphers whose internal states are based on arrays and that they use modular additions to generate output streams. The abundance of array-based stream ciphers with modular additions can be attributed to the fact that, when implemented in software skillfully, they are able to produce outputs at a very high speed. The main contribution of this thesis is a unified analysis of stream ciphers based on arrays and modular addition. During the process, we detect cryptographic weaknesses in the designs of 9 widely known stream ciphers or pseudorandom bit generators (PRBGs). At first, we show some theoretical results on solving an important class of equations known as differential equations of addition (DEA) that combine modular additions over two different algebraic groups such as GF(2) and GF(2). The results include, • proof of the fact that the satisfiability of an arbitrary set of DEA is in the complexity class P, • deriving all the solutions of an arbitrary set of DEA. Next, we apply these results to attack a practical stream cipher named Helix (designed by Ferguson et al.) with both chosen plaintexts and adaptive chosen plaintexts. In the second phase, the thesis closely scrutinizes a number of array-based stream ciphers (or PRBGs) in order to estimate their resistance against distinguishing attacks. We eventually discover, counter-intuitively, that the correlations between the array-indices and their associated array-elements, which apparently seem to be useful from the point of view of implementation purposes, can be exploited to mount distinguishing attacks on such type of ciphers if adequate precautions are not taken. In support of our theoretical findings, we point out distinguishing attacks on 8 practical array-based stream ciphers (or PRBGs),