Miracle-dz/UniFAR-FTUs huggingface dataset:
Catalog of Decaying Kink Oscillations of Coronal Loops in the 24th Solar Cycle

A catalog of kink oscillations of solar coronal loops, which spans during almost all of solar cycle 24, is presented. The catalog is based on the observations made in the extreme ultraviolet band at 171 Å with Solar Dynamics Observatory/Atmospheric Imaging Assembly and includes parameters of 223 oscillating loops in 96 oscillation events. The catalog provides the information about the oscillation locations, time, and dates of the events, associated flare, initial displacement, oscillation period, exponential damping time, and apparent amplitude. The vast majority of the oscillation detections, 84%, were made in the loops situated near or off the solar limb. The oscillation periods are found to range from 1 to 28 minutes, with 74% of the events that have the period in the range of 2–10 minutes. About 90% of the oscillations have the apparent amplitude in the range of 1–10 Mm. The oscillating loop lengths are 70–600 Mm. The typical apparent amplitude is about 1% of the loop length. The oscillation period scales linearly with the loop length, and the damping time scales linearly with the period, which confirm previous findings. The oscillation quality factor scales with the amplitude to the power of minus 0.7. No statistically significant evidence of correlation was found between both the oscillation period and the mean sunspot number, and the loop length and mean sunspot number. The catalog provides the research community with the foundation for the further statistical study of kink oscillations and their use for coronal seismology.
Ribonomic Analysis of Human Pum1 Reveals cis-trans Conservation across Species despite Evolution of Diverse mRNA Target Sets

ABSTRACT PUF family proteins are among the best-characterized regulatory RNA-binding proteins in nonmammalian species, but relatively little is known about mRNA targets or functions of mammalian PUF proteins. In this study, we used ribonomic analysis to identify and analyze mRNAs associated with ribonucleoproteins containing an endogenous human PUF protein, Pum1. Pum1-associated mRNAs were highly enriched for genes encoding proteins that function in transcriptional regulation and cell cycle/proliferation, results consistent with the posttranscriptional RNA regulon model and the proposed ancestral functions of PUF proteins in stem cell biology. Analysis of 3′ untranslated region sequences of Pum1-associated mRNAs revealed a core Pum1 consensus sequence, UGUAHAUA. Pum1 knockdown demonstrated that Pum1 enhances decay of associated mRNAs, and relocalization of Pum1 to stress granules suggested that Pum1 functions in repression of translation. This study is the first in vivo genome-wide mRNA target identification of a mammalian PUF protein and provides direct evidence that human PUF proteins regulate stability of associated mRNAs. Comparison of Pum1-associated mRNAs to mRNA targets of PUF proteins from Saccharomyces cerevisiae and Drosophila melanogaster demonstrates how a well-conserved RNA-binding domain and cognate binding sequence have been evolutionarily rewired to regulate the collective expression of different sets of functionally related genes.
Low-Molecular-Weight Heparin Prophylaxis 24 to 36 Hours After Degenerative Spine Surgery: Risk of Hemorrhage and Venous Thromboembolism

Study Design. Retrospective review. Objective. To assess the safety and efficacy of prophylactic low-molecular-weight heparin (LMWH) started 24 to 36 hours after degenerative spine surgery. Summary of Background Data. Venous thromboembolism (VTE) is a significant postoperative complication best averted with dual mechanical/pharmacological prophylaxis. Pharmacological prophylaxis is widely used in patients with spinal cord injury, but there is no consensus on its role in degenerative spine surgery, particularly after laminectomy with the concurrent risk of epidural hematoma. The literature suggests a small but potentially devastating hemorrhage risk when LMWH is started within 24 hours of spine surgery. An intermediate strategy is delayed LMWH initiation to minimize hemorrhage risk and retain benefits of dual prophylaxis. Methods. Operative reports of the senior author were retrospectively reviewed for all cases of cervical and lumbar laminectomy from 2007 to 2011. Single-level decompressions without fusion and all nondegenerative cases were excluded. Baseline and operative details were recorded. Mechanical prophylaxis was used throughout admission, and prophylactic LMWH was started postoperative day 1 at 10 PM. All cases of postoperative hemorrhage (epidural hematoma, superficial hematoma, persistent wound drainage), deep venous thrombosis, and pulmonary embolism were noted. Results. A total of 367 patients underwent multilevel laminectomy or laminectomy and fusion for degenerative disease. VTE risk factors (age >60 yr, smoking, obesity) were common. No patients receiving LMWH 24 to 36 hours after surgery developed postoperative hemorrhage (95% confidence interval: 0–0.8%). Nearly half of the study population underwent lower extremity ultrasonography or chest computed tomography, and acute VTE was diagnosed in 14 patients (3.8%; 95% confidence interval: 2.1–6.3). Conclusion. LMWH prophylaxis seems to carry a very low hemorrhage risk when started 24 to 36 hours after spine surgery. Larger, prospective studies are needed to assess the safety of early delayed LMWH administration more definitively. Even with aggressive prophylaxis, patients undergoing fusion or multilevel laminectomy for degenerative disease are at significant risk for VTE.
Bacterial spoilage of wine and approaches to minimize it

Bacteria are part of the natural microbial ecosystem of wine and play an important role in winemaking by reducing wine acidity and contributing to aroma and flavour. Conversely, they can cause numerous unwelcome wine spoilage problems, which reduce wine quality and value. Lactic acid bacteria, especially Oenococcus oeni, contribute positively to wine sensory characters, but other species, such as Lactobacillus sp. and Pediococcus sp can produce undesirable volatile compounds. Consequences of bacterial wine spoilage include mousy taint, bitterness, geranium notes, volatile acidity, oily and slimy‐texture, and overt buttery characters. Management of wine spoilage bacteria can be as simple as manipulating wine acidity or adding sulfur dioxide. However, to control the more recalcitrant bacteria, several other technologies can be explored including pulsed electric fields, ultrahigh pressure, ultrasound or UV irradiation, and natural products, including bacteriocins and lysozyme.
Approaches to Microvascular Breast Reconstruction After Total Skin-Sparing Mastectomy: A Comparison of Techniques

IntroductionPreserving the entire breast skin envelope through total skin-sparing mastectomy (TSSM) techniques, in conjunction with immediate autologous reconstruction, can provide excellent aesthetic outcomes for patients. However, postoperative ischemic complications, including nipple-areolar complex (NAC) and skin flap necrosis, can negatively impact reconstructive outcomes. As a strategy for minimizing ischemic complications, we have recently begun performing 2-stage autologous reconstruction after TSSM with immediate tissue expander placement, followed by second-stage microvascular reconstruction, as an alternative to immediate autologous reconstruction. MethodsA prospectively collected database of patients undergoing TSSM and immediate breast reconstruction was reviewed for patients who underwent microvascular reconstruction. Patients were divided into 2 cohorts, those who underwent immediate microvascular reconstruction and those who had a 2-stage procedure. Outcomes for comparison included complication rates and aesthetic outcome scores based on review of postoperative photographs by blinded observers (comprised of plastic surgery attending physicians and residents). ResultsDuring the 2-year study period, there were 21 immediate microvascular reconstructions performed (14 patients) and 16 two-stage reconstructions performed (10 patients). Mean time to completion of reconstruction in the staged cohort was 11.5 months (range, 6.1–21 months). Rates of NAC necrosis were significantly higher in the immediate cohort compared to the staged cohort (29% vs 0%, P = 0.03), which contributed to higher rates of unplanned operative intervention in the immediate cohort (23.8% vs 6.25%, P = 0.14). There were no flap losses in either cohort. Aesthetic scores for NAC color and overall appearance were higher in the staged group compared to the immediate group (P < 0.001 and P = 0.1, respectively), although they were equivalent for nipple position and projection. ConclusionsTwo-stage microvascular reconstruction after TSSM is associated with fewer complications and improved NAC aesthetic outcomes compared to immediate autologous reconstruction. Although time to final reconstruction is longer with the staged approach, the aesthetic benefits and reduction in postoperative complications support the use of this approach to optimize outcomes.
The effects of total body irradiation on some aspects of human iron metabolism.

Erythropoietic function was studied in ten patients following 90 to 100 r total-body irradiation. The plasma Fe59 disappearance rate was measured serially up to 64 days following irradiation, and red cell uptake of Fe59 was measured in four patients. All ten patients demonstrated a marked increase in the T1/2 of the plasma iron disappearance rate during the week following irradiation. There was a second increase in the T1/2 22 to 29 days following irradiation in all six patients studied, indicative of radiation injury and prolonged functional change. Two patients with normal marrows did not demonstrate changes in their red phatic leukemia had significant depression of uptake. At this dose level, the T1/2 of the plasma radioiron disappearance seems to be a sensitive indicator of radiation damage, is associatsd with a decrease in plasma iron turnover, and increases prior to changes in the hemoglobin concentration or reticulocyte count. (auth)
Joint modelling of mixed outcome types using latent variables

After a brief review of the use of latent variables to accommodate the correlation among multiple outcomes of mixed types, through theoretical and numerical calculation, the consequences of such a construction are quantified. The effects of including latent variables on marginal inference in these models are contrasted with the situation for jointly normal outcomes. A simulation study illustrates the efficiency and reduction in bias gains possible in using joint models, and analysis of an example from the field of osteoarthritis illustrates potential practical differences.
Performance of Zero-till Wheat (Triticum aestivum L.) and Weed Species as Influenced by Residue and Weed Management Techniques in Rice based Cropping System

Rice (Oryza sativa L.) Wheat (Triticum aestivum L. emend Fiori & Poal) cropping sequence is the most predominant production system occupying about 18 Mha in Asia, of which 13.5 Mha area in Indo-Gangetic Plains (IGP) of India (10 Mha), Pakistan (2.2 Mha), Bangladesh (0.8 Mha) and Nepal (0.5 Mha) and feeds about 1.3 billion people (20% of the world population) (Farooq et al., 2007, Saharawat et al., 2010). This grin scenario is stemmed from the exhaustive nature of both the crops because belonging to the same family and their extreme tillage requirement. The new Resource Conservation Technologies (RCTs) develop over the past ten years provide an opportunity to reduce the cost of production. Among these, new RCTs, the zero tillage technologies of wheat cultivation have been adopted over large areas. This technology save more than 90% energy, time, labour and helps to produce wheat at a much lower cost. Uncontrolled International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 8 Number 04 (2019) Journal homepage: http://www.ijcmas. com
Prevalence and Risk Factors of Dry Eye Symptoms in a Saudi Arabian Population

Background: The information about dry eye epidemiology in Saudi Arabia is few in literature. Purpose: To estimate the prevalence and identify determinants of dry eye symptoms (DES) in Al-Ahsa, Saudi Arabia. Methods: Using a multi-stage proportionate sampling technique, Saudis of both genders from 6 urban and 4 rural Primary Health Care centers in Al-Ahsa were enrolled. They were interviewed to gather data on sociodemography, symptoms of dry eye, factors potentially related to dry eye, and chronic comorbidities. If one or more of DESs present often or constantly, we labeled the person with DES. Results: We examined 1858 Saudi adults with mean age of 39.3 ± 14.1 years. The age-adjusted prevalence of DES was 32.1% (95% confidence interval [CI] = 30.0–34.3). Multivariate logistic regression analysis showed that female gender (adjusted odds ratio [aOR] = 2.1, 95% CI = 1.7–2.6), older age (>56 years; aOR = 1.5, 95% CI = 1.0–2.1), current smoking (aOR = 1.4, 95% CI = 1.1–1.8) and history of diabetes mellitus (aOR = 1.5, 95% CI = 1.2–2.0) were significantly associated with DES. Nonsignificant variables included residence (urban/rural); work status; wearing contact lenses; multivitamin use; caffeine use; history of trachoma, hypertension, bronchial asthma, coronary artery disease, thyroid disease, arthritis, hemolytic blood diseases (sickle cell-thalassemia), gout, and osteoporosis. Conclusion: DES are highly prevalent among the adult population of Al-Ahsa. Females, persons more than 55 years of age, smokers and diabetics were associated to DES.
Agreement between self-reports, proxy-reports and the National Patient Register regarding diagnoses of cardiovascular disorders and diabetes mellitus in a population-based sample of 80-year-olds

Abstract Background cognitive impairment is common among older adults, necessitating the use of collateral sources in epidemiological studies involving this age group. The objective of this study was to evaluate agreement between self- and proxy-reports of cardiovascular disorders and diabetes mellitus in a population-based sample of 80-year-olds. Further, both self- and proxy-reports were compared with hospital register data. Methods data were obtained from the Gothenburg H70 Birth Cohort Studies in Sweden. The study had a cross-sectional design and information was collected through semi-structured interviews in 2009–2012 from participants born in 1930 (N = 419) and their proxy informants. The National Patient Register provided diagnoses registered during hospital stays. Agreement was measured with Kappa values (K). Results agreement between self- and proxy-reports was substantial for diabetes mellitus (K = 0.79), atrial fibrillation (K = 0.61), myocardial infarction (K = 0.75), angina pectoris (K = 0.73) and hypertension (K = 0.62), and fair for intermittent claudication (K = 0.38) and heart failure (K = 0.40). Compared to the National Patient Register, a large proportion of those with a hospital discharge diagnosis were also self- and proxy-reported. Conclusions proxy informants can be an important source of information, at least for well-defined conditions such as myocardial infarction, angina pectoris and diabetes mellitus.
Etanercept, improved dosage schedules and combinations in the treatment of psoriasis: an update

Etanercept, a subcutaneously administered fully human soluble tumor necrosis factor (TNF) receptor, was initially approved for the treatment of psoriasis at a dose of 25 mg twice weekly in repeated 24-week cycles with the possibility to double the dose in the first 12 weeks of the first cycle. During intermittent treatment, patients retain their ability to respond to etanercept. Recently, a new dosing schedule of etanercept 50 mg once weekly was approved, based on a study in which PASI-75 (75% improvement of Psoriasis Area and Severity Index) was achieved by 37% and 71% of patients at week 12 and 24. Another study demonstrated a PASI-75 of 57% and 69% in pediatric psoriasis patients receiving etanercept 0.8 mg/kg (up to 50 mg) once weekly for 12 and 24 weeks respectively, resulting in European approval from age 8. Based on recent clinical trials, the antipsoriatic effect of etanercept can be markedly increased in combination with acitretin, methotrexate or UVB. The combination with acitretin appears attractive because of its non-immunosuppressive and chemopreventive properties. Etanercept–methotrexate combination therapy is well established in rheumatologic patients. From a long-term perspective, the combination of TNF-inhibitors with phototherapy (photocarcinogenesis) or cyclosporine (carcinogenesis, infections) warrants great caution however. Finally, combination with topical calcipotriol–betamethasone ointment may increase the speed of response to TNF-inhibitors in the first 4 weeks of treatment.
Revisiting quality of life for elders in long-term care: an integrative review.

PURPOSE To review the literature on quality of life (QOL) among elders in long-term care settings, specifically focusing on measurement of QOL, influencing factors, and interventions to improve QOL. CONCLUSION Multiple instruments were used to measure QOL with little overlap and limited ability to compare across studies. Categories of influencing factors included physical function, environment, social support, and mood/spiritual. Interventions targeted changes in environment, physical activity, and meaningful interaction. PRACTICE IMPLICATION Knowledge of the factors influencing QOL and findings from research on interventions will assist nurses in individualizing care approaches to improve QOL among elders in long-term care settings.
University Spin-Off's Transfer Speed - Analyzing the Time from Leaving University to Venture

For academic spin-off's I analyze the length of time between the founder's leaving of academia and the establishment of his firm. Technology transfer can take place even years after leaving the mother institution. A duration analysis reveals that a longer time-lag is caused by the necessity of assembling complementary skills, either by acquisition by a single founder or by searching for suitable team members. Furthermore, new ventures are established earlier if the intensity of technology transfer is high, the founders have access to university infrastructure, or received informal support by former colleagues.
Immunohistochemical findings of sebaceous carcinoma and sebaceoma: Retrieval of cytokeratin expression by a panel of anti‐cytokeratin monoclonal antibodies

This study examined immunohistochemical findings of sebaceous carcinoma and sebaceoma. An immunohistochemical study using 13 anti‐cytokeratin (CK) antibodies (anti‐CK1, 5–8, 10 and 14–20) and 35 cases of sebaceous carcinoma (16 cases on ocular and 19 cases on extraocular regions) and 10 cases of sebaceoma (no cases arose on the eyelids) was performed. Overall, those in ocular lesions were almost the same as those for extraocular lesions in sebaceous carcinoma other than CK8. The findings in sebaceous carcinoma were almost equal to those of sebaceoma. Over 75% of cases with sebaceous carcinoma were positive with anti‐CK5 and anti‐CK14 antibodies and negative with anti‐CK1, CK10, CK15, CK17, CK18 and CK20 antibodies. Most cases (50–75%) of those were positive with CK7 and negative with CK6, CK16, CK19 and CK8. The sensitivity and specificity of immunohistochemical detection of sebaceous carcinoma using the panel of anti‐cytokeratin antibodies were lower than those of other antibodies. Immunohistochemical detection of cytokeratins in diagnosing sebaceous carcinoma should be considered to be ancillary to conventional microscopic findings and those of other antibodies.
Étude de la digestion gastro-intestinale in vitro d'un ingrédient de protéines du lactosérum enrichi en facteurs de croissance

The aim of this work was to study the impact of in vitro digestion of whey proteins and growth factors (TGF-P2 and IGF-I) contained in a bioactive whey protein ingredient, named BWPE, using static and dynamic (TIM-1) digestion systems, then to evaluate the impact of the digestion on some biological activities of the product. Firstly, pepsin digestion of BWPE in a static model demonstrated the resistance of Plactoglobulin (P-LG) to this enzyme, whereas other proteins were gradually hydrolyzed. BWPE content in TGF-P2 and IGF-I partially decreased after 120 min of digestion (50% and 30%, respectively). The murine splenocyte proliferation inhibiting activity of BWPE was unchanged by peptic hydrolysis, suggesting that bioactive components in this product were not degraded by pepsin. BWPE gastrointestinal digestion using the dynamic system (TIM-1) demonstrated that P-lactoglobulin and glycomacropeptide were the most resistant whey components to a 3 h-gastric digestion. However, all proteins contained in BWPE were rapidly hydrolysed in duodenal compartment. At the end of the 5 h-gastrointestinal digestion, a high proportion (73%) of BWPE nitrogen content were absorbed in jejunal and ileal fluids as peptides smaller than 5.8 kDa. More than 95% of TGF-P2 initially contained in BWPE resisted to gastrointestinal enzymes, while IGF-I was totally hydrolysed after 5 h of digestion. The impact of gastrointestinal digestion of BWPE on some biological activities demonstrated that this treatment modified its immunosuppressive activity, not affected Jurkat T cells intracellular glutathione production, and that most of the digested samples were not cytotoxic against the same cell line. In conclusion, the new knowledge gained from this research supported that therapeutic efficacy associated with the presence of TGF-P2 in a dairy ingredient could be related to the resistance of this growth factor during gastrointestinal digestion.