Miracle-dz/UniFAR-FTUs huggingface dataset:
Communication Challenges and Strategies in Distributed DevOps

Even though agile actively seeks collaboration from all its stakeholders, most agile projects do not extend themselves toward the operations people. To solve this problem, DevOps is introduced. DevOps is a conceptual framework for reintegrating development and operations of Information Systems, which is able to break the wall between developers and operations professionals. DevOps improves the work through a collection of principles and practices, centered around close collaboration between Development and Operations personnel. However, both sides have paid little attention to issues faced by each other. Communication gaps is a recurrent problem in agile teams that is also eminent in the relationship between developers and operations. Literature offers little research on this aspect of communication in DevOps. This position paper describes the communication practices from a distributed agile team composed of developers and operations based on communication challenges (geographical, socio-cultural, and temporal distance) and strategies (frequency, direction, modality, and content). From the results we outline possible research focus for future work, aiming to enrich the academia research on the matter as well as to help practitioners to improve their working practices.
Evidence of a Putative Deep Sea Specific Microbiome in Marine Sponges

The microbiota of four individual deep water sponges, Lissodendoryx diversichela, Poecillastra compressa, Inflatella pellicula, and Stelletta normani, together with surrounding seawater were analysed by pyrosequencing of a region of the 16S rRNA gene common to Bacteria and Archaea. Due to sampling constraints at depths below 700 m duplicate samples were not collected. The microbial communities of L. diversichela, P. compressa and I. pellicula were typical of low microbial abundance (LMA) sponges while S. normani had a community more typical of high microbial abundance (HMA) sponges. Analysis of the deep sea sponge microbiota revealed that the three LMA-like sponges shared a set of abundant OTUs that were distinct from those associated with sponges from shallow waters. Comparison of the pyrosequencing data with that from shallow water sponges revealed that the microbial communities of all sponges analysed have similar archaeal populations but that the bacterial populations of the deep sea sponges were distinct. Further analysis of the common and abundant OTUs from the three LMA-like sponges placed them within the groups of ammonia oxidising Archaea (Thaumarchaeota) and sulphur oxidising γ-Proteobacteria (Chromatiales). Reads from these two groups made up over 70% of all 16S rRNA genes detected from the three LMA-like sponge samples, providing evidence of a putative common microbial assemblage associated with deep sea LMA sponges.
Brucella endocarditis - a registry study.

BACKGROUND A zoonotic infection caused by Brucella spp. , brucellosis, is endemic in some areas of the world, like in our country. One of the most devastating conditions related to this infection is endocarditis, although it is rare. Unfortunately, adequate studies on the characteristics of Brucella endocarditis have not been performed. In addition, there was no consensus on optimal type and duration of medical and interventional therapies. AIM To answer the following questions: what are the clinical characteristics of Brucella endocarditis, which type of therapy should be performed, and can an alternative antibiotic regimen be applied? METHODS Patients with the diagnosis of Brucella endocarditis were included in the study during a 6-year period. A total of 10 patients were interrogated for their signs, symptoms, drug use, and clinical conditions. In addition, baseline clinical and laboratory characteristics of the patients were evaluated. RESULTS All patients in the study were male with a mean age of 55.9 +/- 12.7 years. Hospitalisation and total follow-up periods were 52.6 +/- 11.2 and 80.6 +/- 29.0 days, respectively. The most frequently presenting symptom was fever (60%). Dyspnoea and fatigue were the other frequent symptoms in descending order. Valve pathology was present in 70% of the study population. The aortic valve was affected more than the mitral valve. Affected mitral valves had rheumatic disease whereas only 57% of the aortic valves had underlying pathology. Isolation of Brucella spp. was possible in 20% of the patients. Mortality rate was 30% in our study; 20% of the patients were on medical follow-up without disease progression and with clinical stability, 60% of patients were on a combination therapy with a tetracycline group, a rifampicin, and a third-generation cephalosporin. Patients who took this combination and underwent aortic valve replacement had good clinical results with a mortality rate of 20%. The 30% of patients were on a combination therapy with a tetracycline group, rifampicin, and an aminoglycoside group. Mortality rate with this combination was 33%, although the success rate was 67%. CONCLUSION Brucella endocarditis should be considered in the differential diagnosis in patients with vegetations on the cardiac valves, especially in endemic areas. Optimal therapy seems to be a combination of antibiotics and surgery, although medical therapy can be an alternative, especially in stable patients. Addition of a third-generation cephalosporin instead of aminoglycoside to the combination therapy is an alternative.
P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 Determine the Pharmacokinetics of Etoposide

Purpose: Despite the extensive use of etoposide for the treatment of different malignant neoplasms, its main pharmacokinetic determinants are not completely defined. We aimed to study the impact of P-glycoprotein (P-gp/ABCB1) and the multidrug resistance proteins ABCC2 (MRP2) and ABCC3 (MRP3) on the pharmacokinetics of etoposide. Experimental Design: Abcb1a/1b−/−, Abcc2−/−, Abcc3−/−, Abcb1a/1b;Abcc2−/−, and Abcc2;Abcc3−/− mice were used to investigate the separate and combined impact of P-gp, Abcc2, and Abcc3 on the in vivo behavior of etoposide. Results: P-gp restricted the oral (re)uptake of unchanged etoposide, and mediated its excretion across the gut wall. In contrast, hepatobiliary excretion was almost entirely dependent on Abcc2. Yet, complete loss of Abcc2 did not result in elevated liver or plasma concentrations of etoposide. Instead, Abcc2−/− mice displayed an increased hepatic formation of etoposide glucuronide, which was secreted via Abcc3 from the liver to the blood circulation and eliminated with the urine. Combination Abcc2;Abcc3−/− mice had highly increased accumulation of etoposide glucuronide in their livers, whereas both single knockouts did not, indicating that Abcc2 and Abcc3 provide alternative pathways for the hepatic elimination of etoposide glucuronide. Conclusions: P-gp, ABCC2, and ABCC3 significantly affect the pharmacokinetics of etoposide and/or etoposide glucuronide. Variation in transporter expression or activity may explain the high variation in oral availability of etoposide (25-80%) among cancer patients. However, despite the fact that substantial variations in transporter activity can occur, we believe that cancer patients are often relatively protected from etoposide toxicity due to overlapping functions of these transporters in the elimination of etoposide. Clin Cancer Res; 16(1); 130–40
A Cellular Micro-RNA, let-7i, Regulates Toll-like Receptor 4 Expression and Contributes to Cholangiocyte Immune Responses against Cryptosporidium parvum Infection*

Toll-like receptors (TLRs) are important pathogen recognition molecules and are key to epithelial immune responses to microbial infection. However, the molecular mechanisms that regulate TLR expression in epithelia are obscure. Micro-RNAs play important roles in a wide range of biological events through post-transcriptional suppression of target mRNAs. Here we report that human biliary epithelial cells (cholangiocytes) express let-7 family members, micro-RNAs with complementarity to TLR4 mRNA. We found that let-7 regulates TLR4 expression via post-transcriptional suppression in cultured human cholangiocytes. Infection of cultured human cholangiocytes with Cryptosporidium parvum, a parasite that causes intestinal and biliary disease, results in decreased expression of primary let-7i and mature let-7 in a MyD88/NF-κB-dependent manner. The decreased let-7 expression is associated with C. parvum-induced up-regulation of TLR4 in infected cells. Moreover, experimentally induced suppression or forced expression of let-7i causes reciprocal alterations in C. parvum-induced TLR4 protein expression, and consequently, infection dynamics of C. parvum in vitro. These results indicate that let-7i regulates TLR4 expression in cholangiocytes and contributes to epithelial immune responses against C. parvum infection. Furthermore, the data raise the possibility that micro-RNA-mediated post-transcriptional pathways may be critical to host-cell regulatory responses to microbial infection in general.
Molecular typing of Pyrus based on RAPD markers

Molecular characterisation and phenetic similarities between several cultivars of P. communis and P. pyrifolia, and genotypes of P. cordata, P. bourgaeana and P. pyraster were investigated through RAPD markers. Sixty decamer primers were screened, generating polymorphic patterns of Occidental and Oriental pear genotypes. Twenty-two selected primers originated clear and reproducible patterns, produced a total of 358 bands, 327 of them polymorphic. For 10 of the 12 genotypes analysed it was possible to find genotype-specific RAPDs and fragment patterns which could be used for cultivar identification. The patterns distinguished between genotypes and their analysis established a first approach to phenetic classification within the Pyrus genus based on DNA markers, clustering the genotypes according to their geographic origin. RAPD analysis of in vitro and in vivo material of seven cultivars was also performed, resulting in identical patterns for each genotype. # 1999 Elsevier Science B.V. All rights reserved.
Translating GWAS Into the Flow-Regulated Modulation of Lipid Mediator Signaling.

It is well accepted that the stimulation of endothelial cells by the blood flowing over them can alter the generation of endothelium-derived vasodilators, such as nitric oxide (NO), to fine tune vascular tone. The shear stress generated by the flowing blood can also affect endothelial cell signaling and while laminar shear stress, which has also been termed atheroprotective flow, generally activates anti-inflammatory signals, areas of the endothelium exposed to disturbed (turbulent or oscillatory) and low flow are characterized by an inflammatory footprint. The latter is typically associated with elevated nuclear factor κB activation and adhesion molecule expression accompanied by the concomitant attenuated expression and activation of major protective factors, notably the endothelial NO synthase and Kruppel-like factors, KLF2 and KLF4.1 Article, see p e41 In this issue of Circulation Research , Wu et al2 report that an integral membrane protein previously described as a p120-catenin–associated integrin ligand localized to the adherens junction of endothelial cells3 is implicated in endothelial cell responsiveness to flow. The protein in question is phosphatidic acid phosphatase type 2B (PPAP2B; also known as lipid phosphate phosphatase 3), and as the name suggests it is responsible for the dephosphorylation and inactivation of lipid substrates including lysophosphatidic acid (LPA), ceramide 1-phosphate, and sphingosine 1-phosphate.4 The proposed role of PPAP2B is not in mechanosensing per se but rather in the modulation of endothelial cell sensitivity to circulating LPA (Figure). The authors link PPAP2B with responsiveness to flow by (1) the fact that its expression was attenuated in areas of the pig …
Software exploitable hardware Trojans in embedded processor

Growing threat of hardware Trojan attacks in untrusted foundry or design house has motivated researchers around the world to analyze the threat and develop effective countermeasures. In this paper, we focus on analyzing a specific class of hardware Trojans in embedded processor that can be enabled by software or data to leak critical information. These Trojans pose a serious threat in pervasively deployed embedded systems. An attacker can trigger these Trojans to extract valuable information from a system during field deployment. We show that an adversary can design a low-overhead hard-to-detect Trojan that can leak either secret keys stored in a processor, the code running in it, or the data being processed.
Neck range of motion and use of computer head controls

Head controls provide an alternative means of computer access. This study determined whether neck movement limitations are associated with reduced performance with such head controls. This study also identified features of the cursor movement path that could aid in assessing computer access limitations. Fifteen subjects without disabilities and ten subjects with disabilities received neck range of motion evaluations and performed computer exercises using head controls. Reduced neck range of motion was correlated with reduced accuracy (R2 = 93.5%) and speed (R2 = 79.5%) in icon selection. A model was developed with the use of cursor positioning time and number of velocity peaks to identify when a person was having difficulty with target acquisition (kappa = 0.81). Models such as this may allow head controls to adapt to a user's needs, accommodating difficulties resulting from neck range of motion limitations.
A Network Centered on Ventral Premotor Cortex Exerts Both Facilitatory and Inhibitory Control over Primary Motor Cortex during Action Reprogramming

Ventral premotor cortex (PMv) is widely accepted to exert an important influence over primary motor cortex (M1) when hand movements are made. Although study of these interactions has typically focused on their excitatory nature, given its strong connections with both ventral and opercular frontal regions, one feature of the influence of PMv over M1 may be inhibitory. Paired-pulse transcranial magnetic stimulation (ppTMS) was used to examine functional interactions between human PMv and M1 during the selection and reprogramming of a naturalistic goal-directed action. One of two cylinders was illuminated on each trial. It was then grasped and picked up. On some trials, however, subjects had to reprogram the action as the illuminated cylinder was switched off and the other illuminated simultaneously with reach initiation. At a neurophysiological level, the PMv paired-pulse effect (PPE) on M1 corticospinal activity was facilitatory after the initial target presentation and during movement initiation. When reprogramming was required, however, the PPE became strongly inhibitory. This context-dependent change from facilitation to inhibition occurred within 75 ms of the change of target. Behaviorally, PMv-M1 ppTMS disrupted reprogramming. Diffusion-weighted magnetic resonance image scans were taken of each subject. Intersubject differences in the facilitation–inhibition contrast of PMv-M1 interactions were correlated with fractional anisotropy of white-matter in ventral prefrontal, premotor, and intraparietal brain areas. These results suggest that a network of brain areas centered on PMv inhibits M1 corticospinal activity associated with undesired movements when action plans change.
Crowdsourced Knowledge Acquisition: Towards Hybrid-Genre Workflows

Novel social media collaboration platforms, such as games with a purpose and mechanised labour marketplaces, are increasingly used for enlisting large populations of non-experts in crowdsourced knowledge acquisition processes. Climate Quiz uses this paradigm for acquiring environmental domain knowledge from non-experts. The game's usage statistics and the quality of the produced data show that Climate Quiz has managed to attract a large number of players but noisy input data and task complexity led to low player engagement and suboptimal task throughput and data quality. To address these limitations, the authors propose embedding the game into a hybrid-genre workflow, which supplements the game with a set of tasks outsourced to micro-workers, thus leveraging the complementary nature of games with a purpose and mechanised labour platforms. Experimental evaluations suggest that such workflows are feasible and have positive effects on the game's enjoyment level and the quality of its output.
When are erasure correcting block codes better than convolutional codes in a multi-hop network?

In this paper we investigate the effect of imposing a maximum allowed delay on the symbol loss probability for a set of rate 1/2 erasure correcting codes. Given some maximum allowable delay, we define the effective symbol loss probability to be the probability that a symbol is received too late or not at all. Consider a network with three nodes; source, relay, and sink. The source encodes data using an erasure correcting code, the relay decodes, recodes, and finally the sink decodes using Gaussian elimination. We compare the effective symbol loss probability of systematic triangular block codes, dense block codes, and systematic convolutional codes. For a wide range of packet loss probabilities and allowable symbol delays, our results show that the systematic triangular block codes are superior. Our results also show that the field size does not affect the gain in effective symbol loss probability.
MARCKS is involved in methylmercury-induced decrease in cell viability and nitric oxide production in EA.hy926 cells

Methylmercury (MeHg) is a persistent environmental contaminant that has been reported worldwide. MeHg exposure has been reported to lead to increased risk of cardiovascular diseases; however, the mechanisms underlying the toxic effects of MeHg on the cardiovascular system have not been well elucidated. We have previously reported that mice exposed to MeHg had increased blood pressure along with impaired endothelium-dependent vasodilation. In this study, we investigated the toxic effects of MeHg on a human endothelial cell line, EA.hy926. In addition, we have tried to elucidate the role of myristoylated alanine-rich C kinase substrate (MARCKS) in the MeHg toxicity mechanism in EA.hy926 cells. Cells exposed to MeHg (0.1–10 µM) for 24 hr showed decreased cell viability in a dose-dependent manner. Treatment with submaximal concentrations of MeHg decreased cell migration in the wound healing assay, tube formation on Matrigel and spontaneous nitric oxide (NO) production of EA.hy926 cells. MeHg exposure also elicited a decrease in MARCKS expression and an increase in MARCKS phosphorylation. MARCKS knockdown or MARCKS overexpression in EA.hy926 cells altered not only cell functions, such as migration, tube formation and NO production, but also MeHg-induced decrease in cell viability and NO production. These results suggest the broad role played by MARCKS in endothelial cell functions and the involvement of MARCKS in MeHg-induced toxicity.
Graph mining: Laws, generators, and algorithms

How does the Web look? How could we tell an abnormal social network from a normal one? These and similar questions are important in many fields where the data can intuitively be cast as a graph; examples range from computer networks to sociology to biology and many more. Indeed, any M : N relation in database terminology can be represented as a graph. A lot of these questions boil down to the following: “How can we generate synthetic but realistic graphs? ” To answer this, we must first understand what patterns are common in real-world graphs and can thus be considered a mark of normality/realism. This survey give an overview of the incredible variety of work that has been done on these problems. One of our main contributions is the integration of points of view from physics, mathematics, sociology, and computer science. Further, we briefly describe recent advances on some related and interesting graph problems.
Enhanced and Impaired Attentional Performance After Infusion of D1 Dopaminergic Receptor Agents into Rat Prefrontal Cortex

The role in spatial divided and sustained attention of D1 and D2-like dopamine (DA) receptors in the rat prelimbic medial prefrontal cortex (mPFC) was investigated in a five-choice serial reaction time task. Rats were trained to detect brief flashes of light (0.5–0.25 sec) presented randomly in a spatial array of five apertures. When performance stabilized, animals received bilateral microinfusions of either the D1 DA receptor antagonist SCH 23390, the D1 DA receptor agonist SKF 38393, or the D2 DA antagonist sulpiride into the mPFC. Rats were divided into two groups, with low (<75% correct) and high (>75%) baseline levels of accuracy. Infusions of the D2 receptor antagonist sulpiride had no significant effect on any task variable. SCH 23390 (0.3 μg) selectively impaired the accuracy of attentional performance in rats in the high baseline condition. By contrast, SKF 38393 (0.06 μg) enhanced the accuracy of attentional performance in the low baseline condition, a lower dose (0.03 μg) also increasing the speed of making correct responses. Finally, the beneficial effects of SKF-383893 on choice accuracy were antagonized by SCH 23390 (1.0 μg). The results provide apparently the first demonstration of enhanced cognitive function after local administration of a D1 receptor agonist to the mPFC and suggest dissociable roles of D1 and D2 DA receptors of the mPFC in modulating attentional function.
Genome-Wide Analysis Reveals a Complex Pattern of Genomic Imprinting in Mice

Parent-of-origin–dependent gene expression resulting from genomic imprinting plays an important role in modulating complex traits ranging from developmental processes to cognitive abilities and associated disorders. However, while gene-targeting techniques have allowed for the identification of imprinted loci, very little is known about the contribution of imprinting to quantitative variation in complex traits. Most studies, furthermore, assume a simple pattern of imprinting, resulting in either paternal or maternal gene expression; yet, more complex patterns of effects also exist. As a result, the distribution and number of different imprinting patterns across the genome remain largely unexplored. We address these unresolved issues using a genome-wide scan for imprinted quantitative trait loci (iQTL) affecting body weight and growth in mice using a novel three-generation design. We identified ten iQTL that display much more complex and diverse effect patterns than previously assumed, including four loci with effects similar to the callipyge mutation found in sheep. Three loci display a new phenotypic pattern that we refer to as bipolar dominance, where the two heterozygotes are different from each other while the two homozygotes are identical to each other. Our study furthermore detected a paternally expressed iQTL on Chromosome 7 in a region containing a known imprinting cluster with many paternally expressed genes. Surprisingly, the effects of the iQTL were mostly restricted to traits expressed after weaning. Our results imply that the quantitative effects of an imprinted allele at a locus depend both on its parent of origin and the allele it is paired with. Our findings also show that the imprinting pattern of a locus can be variable over ontogenetic time and, in contrast to current views, may often be stronger at later stages in life.