Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment Approaches for Relapsing and Refractory Multiple Myeloma

Relapsing patients with multiple myeloma show a response rate higher than 50% with the resumption of the initial chemotherapy. However, since the duration of second responses are short, HDT/autotransplantation is recommended in patients with sensitive relapse. In patients with primary refractory myeloma the best treatment approach seems to be early HDT/autotransplantation. It is crucial to recognize a subset of patients who do not respond to the initial chemotherapy but who have non-progressive disease in order to avoid the administration of salvage regimens until clinical disease progression occurs. The treatment of patients with refractory relapse is disappointing. The most promising agent in this situation is thalidomide. Patients with late relapse after autologous transplantation can benefit from a second autologous transplant. The results of the allogeneic transplantation after autotransplantation are disappointing. In heavily pretreated resistant patients a conservative approach with alternate day prednisone (30 to 50 mg) along with pulse cyclophosphamide (800 to 1200 mg every 2 to 3 weeks) is recommended.
Micromagnetic Studies at Finite Temperature on FePt–C Granular Films

A new micromagnetic method using the hybrid Monte Carlo (HMC) algorithm has been developed, and the magnetic properties at finite temperature can be simulated. In this paper, the HMC micromagnetics are applied on the polycrystalline FePt–C granular films for heat-assisted magnetic recording, where the significant parameters such as the temperature-dependent saturation magnetization $M_{s}$ (T) are measured by experiments. The Voronoi polycrystalline microstructure is built upon a regular mesh of micromagnetic cells. The magnetization (M–H) loops below the Curie temperature are calculated; they agree well with experiments at 300, 400, 500, and 600 K, respectively, which have confirmed the validity of the HMC micromagnetic method. Besides, the M–H loop at 700 K, which currently cannot be measured by experiments, can also be simulated using the HMC algorithm, which shows superparamagnetic properties.
Role of class II human leucocyte antigens in the progression from early to definite systemic sclerosis.

OBJECTIVE HLAs have been extensively associated with SSc susceptibility but their role in the progression of the disease is poorly understood. In 2013 the ACR and European League Against Rheumatism (EULAR) jointly defined criteria for the classification of SSc that allow the early identification of definite SSc patients. In this study we investigated the role of HLA class II antigens in the progression from early to definite SSc. METHODS One hundred and fifty-eight subjects with early SSc according to LeRoy and Medsger criteria and no other manifestation indicative of definite SSc at referral were considered. All the patients underwent high-resolution HLA class II typing and the appraisal of definite SSc was retrospectively conducted in a prospective manner. Lifetime analysis was conducted to gauge the effect of genetic and clinical characteristics on progression of the disease. RESULTS The median estimated time to progression was 45 months from referral; the 5 and 10 year estimates of progression were 59.8% and 80%, respectively. ACAs were associated with a reduced risk of progression [median survival 55 vs 23 months for ACA-positive vs ACA-negative patients, P = 0.035; hazard ratio (HR) 0.67 (95% CI 0.458, 0.979)]. HLA alleles within the HLA DQ5-DR1 haplotype [HLA-DRB1*0101-HLA-DQA1*0101(4)-HLA-DQB1*0501] reduced the risk of progression of the disease [median survival 108 vs 44 months for DQ5-DR1 carriers vs DQ5-DR1 non-carriers; HR 0.388 (CI 0.211, 0.712), P = 0.001, corrected P = 0.014]. In multivariate models, the effect of genetics was found to be independent of ACA positivity or other baseline factors; additive risks were observed when the DQ5-DR1 haplotype and ACA were jointly considered. CONCLUSION HLA class II alleles within the HLA DQ5-DR1 haplotype are associated with lower rates of progression from early to definite SSc.
Stereotype Content Associated with Immigrant Groups in Switzerland

This research examines stereotypes associated with immigrant groups in Switzerland. In line with the stereotype content model, we expected immigrant groups to be perceived differentially on the dimensions of warmth and competence as a function of their national origin. Second, we expected the stereotype content to be predominantly mixed, that is, groups are either perceived as warmer than competent or as colder than competent. Third, we expected stereotype contents to correlate with their sociostructural precursors, namely, competition and status. The results supported our hypotheses: The nine most salient immigrant groups fell into five meaningful clusters, based on their perceived warmth and competence. Most stereotype contents were mixed. Moreover, we found that warmth perceptions were predicted by both competition and status, whereas competence perceptions were predicted by status only. This research emphasizes the importance of considering the diversity of the immigrant population when studying immigrant stereotypes.
Homogeneity of Effects: Interaction

Many medical studies are carried out to investigate the size of some effect, for example the treatment effect in a controlled clinical trial or the risk of exposure to some substance in an observational study. To this end it is usual to compare groups of subjects, such as those receiving active treatment with those getting placebo or those exposed with those not exposed. The comparison is often made using a statistical technique, such as a t-test, a χ test, ANCOVA. If these techniques (or indeed many other statistical techniques) are applied to the groups as a whole then only one estimate of the size of an effect will be obtained, i.e. there is an implicit assumption that the effect size is constant across different types of patients or subjects. In practice this may not be sensible, for example women may respond to a hormonal treatment differently from men or the effect of exposure to an environmental toxin may be different for smokers and non-smokers. Such heterogeneity of effect is usually investigated by repeating analyses on selected subgroups. Virtually any trial report will include a series of subgroup analyses , and manoeuvres with similar motivation occur in many epidemiological studies. Although the biology or medicine behind this approach may be sensible, there are several statistical traps for the unwary and some of these are discussed in this note.
Sexuality after treatment for early prostate cancer: exploring the meanings of "erectile dysfunction".

OBJECTIVE To explore perceptions of the impact of erectile dysfunction on men who had undergone definitive treatment for early nonmetastatic prostate cancer. DESIGN Seven focus groups of men with early prostate cancer. The groups were semistructured to explore men's experiences and quality-of-life concerns associated with prostate cancer and its treatment. SETTING A staff model health maintenance organization, and a Veterans Affairs medical center. PATIENTS Forty-eight men who had been treated for early prostate cancer 12 to 24 months previously. RESULTS Men confirmed the substantial effect of sexual dysfunction on the quality of their lives. Four domains of quality of life related to men's sexuality were identified: 1) the qualities of sexual intimacy; 2) everyday interactions with women; 3) sexual imagining and fantasy life; and 4) men's perceptions of their masculinity. Erectile problems were found to affect men in both their intimate and nonintimate lives, including how they saw themselves as sexual beings. CONCLUSIONS Erectile dysfunction, the most common side effect of treatment for early prostate cancer, has far-reaching effects upon men's lives. Assessment of quality of life related to sexual dysfunction should address these broad impacts of erectile function on men's lives. Physicians should consider these effects when advising men regarding treatment options. Physicians caring for patients who have undergone treatment should address these psychosocial issues when counseling men with erectile dysfunction.
From temporal processing to developmental language disorders: mind the gap

The ‘rapid temporal processing’ and the ‘temporal sampling framework’ hypotheses have been proposed to account for the deficits in language and literacy development seen in specific language impairment and dyslexia. This paper reviews these hypotheses and concludes that the proposed causal chains between the presumed auditory processing deficits and the observed behavioural manifestation of the disorders are vague and not well established empirically. Several problems and limitations are identified. Most data concern correlations between distantly related tasks, and there is considerable heterogeneity and variability in performance as well as concerns about reliability and validity. Little attention is paid to the distinction between ostensibly perceptual and metalinguistic tasks or between implicit and explicit modes of performance, yet measures are assumed to be pure indicators of underlying processes or representations. The possibility that diagnostic categories do not refer to causally and behaviourally homogeneous groups needs to be taken seriously, taking into account genetic and neurodevelopmental studies to construct multiple-risk models. To make progress in the field, cognitive models of each task must be specified, including performance domains that are predicted to be deficient versus intact, testing multiple indicators of latent constructs and demonstrating construct reliability and validity.
A semiclassical reversibility paradox in simple chaotic systems

Using semiclassical methods, it is possible to construct very accurate approximations in the short-wavelength limit of quantum dynamics that rely exclusively on classical dynamical input. For systems whose classical realization is strongly chaotic, there is an exceedingly short logarithmic Ehrenfest time scale, beyond which the quantum and classical dynamics of a system necessarily diverge, and yet the semiclassical construction remains valid far beyond that time. This fact leads to a paradox if one ponders the reversibility and predictability properties of quantum and classical mechanics. They behave very differently relative to each other, with classical dynamics being essentially irreversible/unpredictable, whereas quantum dynamics is reversible/stable. This begs the question: ‘How can an accurate approximation to a reversible/stable dynamics be constructed from an irreversible/unpredictable one? ’ The resolution of this incongruity depends on a couple of key ingredients: a well-known, inherent, one-way structural stability of chaotic systems; and an overlap integral not being amenable to the saddle point method.
Family Influences on School Achievement in Low-Income, African American Children.

The authors examined the achievement-related beliefs and behaviors of parents of economically disadvantaged African American youth, and the relations among parental factors and children's academic self-concept and achievement. Forty-one children and their primary caregivers were interviewed. Parents reported on their academic-related beliefs and behaviors. Children completed measures of academic self-concept and 2 standardized achievement tests: 1 during the summer and 1 at the end of the following school year. Significant and positive relations were found between parental belief and behavior measures within the domains of reading and math; however, parental beliefs were more strongly linked with child outcomes than were parents' achievement-oriented behaviors. The relation between parental beliefs and child outcomes was not mediated by children's academic self-concept. Results are discussed in light of models of family influences on achievement.
Theory-Based Predictors of Intention to Engage in Precautionary Sexual Behavior Among Puerto Rican High School Adolescents

Abstract Predictors of intention to abstain from sexual intercourse or use condoms consistently with both main and other partners were investigated in 431 Puerto Rican high school students. The basis for this study was the theories of reasoned action (TRA) and planned behavior (TPB), and two predictors from the theory of interpersonal behavior (TIB). As suggested by the TPB, self-efficacy substantially increased the predictability of both intentions over and above the TRA variables (attitude and subjective norm), and was the only variable that significantly predicted these intentions with both types of sexual partner. Anticipated emotional reaction and past behavior from the TIB, and gender further improved the predictions, but their contribution depended on the specific intention and the type of partner. The findings suggest that an augmented theory of planned behavior could be useful for understanding intention to engage in precautionary sexual behaviors among Puerto Rican adolescents.
To what degree does thepromotion system reward faculty research productivity?

This study explores the research question: Does the promotion system in Taiwan reward faculty research productivity? By conducting event history analyses, I have demonstrated that the simple answer to the question is ‘yes. ’ After controlling for the effects of demography, education, institutions and seniority, the discrete‐time logit models indicate that the number of research publications predicts the odds of promotion well. Although the promotion system is unquestionably effective in rewarding research productivity for at least some faculty, whether the system is truly universalistic or equitable remains an open question. Female and younger faculty members are clearly disadvantaged in seeking promotion. Future research is recommended to study how particularism operates in the Taiwanese academic community.
Affective Context of Sadness and Physiological Response Patterns

This study was conducted to test the hypothesis that two films that induce a sad feeling would elicit different physiological responses depending on an additional context of the film contents related to either avoidance (disgust) or attachment (tenderness). Reactivity was evaluated for facial behavior, heart rate, pulse transit time, skin conductance, and subjective experience. Participants reported feeling less happy and showed increased facial activity related to the sad content of both films. The sad film related to avoidance induced an increase in skin conductance level and response rate. In contrast, the sad film related to attachment induced a decrease in amplitude of skin conductance responses and heart rate. The study showed that while the common sad content of both films disturbed mood or provoked negative feelings, additional affective contexts induced either a decrease or an increase in physiological arousal.
Jesus Didn’t Teach Us to Juggle

Growing research suggests that work–family conflict is harmful to individual well-being. However, few studies have examined this relationship among African Americans, as well as what cultural institutions and practices may help in dealing with the stress of work–family conflict. This study suggests that religion may be an important resource for African Americans in the face of work–family conflict. Using data from the National Survey of Religion and Family Life, a telephone survey of working-age U.S. adults, this study outlines a series of arguments linking work–family conflict, religious involvement, and life satisfaction among African Americans. The results suggest some support for religious involvement in moderating—or buffering—the harmful effects of work–family conflict on the life satisfaction of African Americans. Study limitations are identified and several promising directions for future research are discussed.
Which Chinese creators are famous and why: Views from Hong Kong and Mainland Chinese students

The list of recognized creators is constantly changing with the passage of time. An up-to-date list of recognized Chinese creators emerges from a survey of a large sample of Chinese students in various places in China. To understand the sustain-ability of the creators' fame, this study examines how the creators' personal characteristics affect their fame, creativity, social contribution, and esteem, based on the students' viewpoints. Results show that scientists, compared with other professionals, consistently maintained higher fame, creativity, and social contribution. This finding is consistent with the emphasis on science, rationality, and objectivity in modern education as well as the meritorious evaluation bias in perceiving the utility of creativity in Chinese society. The creator's creativity showed an inverted-U shaped relationship to fame. Hence, a moderate level of creativity was associated with the highest fame in the creator. There were some differences between Hong Kong and Mainland Chinese students' perceptions of the sustainability of fame, which is largely attributable to the influence of commercialism in Hong Kong.
Enhanced Radiosensitivity and Chemosensitivity of Breast Cancer Cells by 2-Deoxy-D-Glucose in Combination Therapy

Breast cancer is the most common malignancy, and it is also the major cause of cancer-related deaths of women worldwide. Breast cancer treatment involves surgery, chemotherapy, radiation therapy, or combination therapy, and novel strategies are needed to boost the oncologic outcome. The non-metabolizable glucose analogue, 2-deoxy-D-glucose (2-DG) which inhibits glucose synthesis and adenosine triphosphate production, is one of the important discoveries involving the disturbances that can be caused to the process of the metabolism. The glucose analogue, 2-DG, is known as a tumor sensitizer to irradiation (IR) and chemotherapy, which help improve the treatment rates. It enhances the cytotoxicity via oxidative stress, which is more redundant in tumor cells than in normal ones. This article provides a brief summary on studies related to 2-DG chemo-/radio-sensitization effects by combination therapy of 2-DG/IR or 2-DG/doxorubicin.
A Fresh Start for a ‘failing school’? A qualitative study

This paper examines Fresh Start, a New Labour flagship initiative to raise education ‘standards’ in a radical and innovative way. Drawing on a qualitative study of a comprehensive school in England, I argue that the initiative added to the problems faced by the ‘failing school’ and promoted rather traditional ways of raising ‘standards’ due to the close surveillance that Fresh Start schools were subjected to. In the case studied, the needs of the pupils that the initiative was meant to address were being sacrificed in the school's construction of a ‘successful’ identity. While the initiative has now lost momentum, some lessons can still be learnt. This paper illustrates the complexity of creating a new school, as well as the need to attend to the specificities of the local context and experiences in raising ‘standards for all’ pupils.
Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice.

BACKGROUND Inflammation and oxidative stress are believed to contribute to neuronal degeneration of the nigrostriatal dopaminergic (DA) pathway in Parkinson's disease. Curcumin, a component of the yellow curry spice, has been reported possessing anti-inflammatory and anti-oxidative effects. AIM The present study investigated the effects of curcumin on the extent of DA innervation, glial response, and Cu/Zn superoxide dismutase (SOD1) expression in the striatum of 6-hydroxydopamine (6-OHDA)-lesioned mice. MATERIALS AND METHODS 6-OHDA was unilaterally injected into the right striatum of ICR male mice. Curcumin (200 mg/kg) was administered daily for 7 days starting instantaneously after 6-OHDA injection. Seven days after 6-OHDA insult, mice were euthanized and striatal sections were collected, immunohistochemically stained, and quantitated for tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP), ionized calcium binding adapter molecule 1 (Iba1), and SOD1 immunoreactivity. RESULTS 6-OHDA injection triggered a significant loss of TH-immunoreactive (-IR) axons, induced reaction of GFAP-IR astrocytes and Iba1-IR microglia, and decreased SOD1 expression in the 6-OHDA-lesioned striatum. Curcumin attenuated loss of TH-IR fibers, diminished activation of astrocytes and microglia, and sustained SOD1 level in the lesioned striatum. CONCLUSIONS These results suggest that curcumin counteracts the neurotoxicity of 6-OHDA through its anti-inflammatory properties (inhibition of glial response) and preservation of SOD1 expression.
Trauma-informed sexuality education: recognising the rights and resilience of youth

Experiences of maltreatment during childhood and the emergence of sexuality during adolescence are both critical developmental issues that intersect in meaningful ways, yet the two are often isolated from each other in practice. Despite the prevalence of childhood maltreatment, sexuality education does not accommodate young people with trauma histories. This results in curricula and content that ignore the particular needs and experiences of a proportion of students in sexuality education classrooms. Trauma interventions commit a similar oversight by neglecting the prospects for positive, growth-promoting sexual experiences and relationships among young people who have been abused. The failure to account for young people's resilience in the sexual domain results in treatment approaches that emphasise sexual risks (e.g. revictimisation) and problem behaviours to the exclusion of guidance in cultivating positive sexualities. Consequently, many forms of sexuality education and maltreatment interventions may be of limited effectiveness and relevance in promoting the future sexual well-being of young people with histories of trauma. To redress this gap, we advocate for trauma-informed sexuality education, an approach that acknowledges past experiences of abuse, the promise of resilience, and young people's right to positive sexualities.
Lobular carcinoma in situ on core biopsy-what is the clinical significance?

AIM To retrospectively review the surgical histological findings in all cases where lobular carcinoma in situ(LCIS) was identified on percutaneous core biopsy (CB) performed as part of the Cambridge and Huntingdon breast screening programme. MATERIALS AND METHODS We retrospectively reviewed all the core biopsies performed in our department for screen detected abnormalities over a 5-year period between 1 April 1994 and 31 March 1999. All patients where LCIS was identified on CB were reviewed. As the significance of LCIS on CB was unclear all went on to surgical excision. We reviewed the clinical and imaging findings, biopsy technique and subsequent surgical histology of each patient. RESULTS During the study period 60 769 women were invited for screening, of whom 47 975 attended (attendance rate = 79%). Of these, 2330 (4.9%) were recalled for assessment and 749 (1.6%) underwent CB. A malignant diagnosis was obtained in 311 (42%), 211 invasive and 100 in situ lesions. LCIS was identified on CB in 13 (2%). LCIS was the only lesion identified in seven cases. All seven cases subsequently underwent surgical excision. Surgical histology revealed a single case of LCIS and invasive lobular carcinoma. There were two cases of LCIS and DCIS one with a probable focus of invasive ductal carcinoma. In one case LCIS was identified in association with a radial scar. In three of the seven cases LCIS was the only abnormality on both CB and surgical biopsy. CONCLUSION Our series shows that isolated LCIS on CB following mammographic screening is an infrequent finding, and it may be associated with either an invasive cancer or DCIS. It is therefore advisable that when LCIS is identified on CB, surgical excision of the mammographic abnormality should be performed. Decisions on management should be undertaken in a multidisciplinary setting taking into account clinical and imaging findings.