Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of assessment of biomechanical exposure at the workplace in the prevention of musculoskeletal disorders.

Print ISSN: 0355-3140 Electronic ISSN: 1795-990X Copyright (c) Scandinavian Journal of Work, Environment & Health Editorial Scand J Work Environ Health 2010;36(1):1-2 doi:10.5271/sjweh.2882 The role of assessment of biomechanical exposure at the workplace in the prevention of musculoskeletal disorders by Burdorf A Affiliation: Department of Public Health, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. a.burdorf@erasmusmc.nl Refers to the following texts of the Journal: 2001;27(2):
Executive Function in Education: From Theory to Practice.

Part 1. Executive Function: Theoretical and Conceptual Frameworks. M.B. Denckla, Executive Function: Binding Together the Definitions of Attention-Deficit/Hyperactivity Disorder and Learning Disabilities. S. Moran, H. Gardner, "Hill, Skill, and Will": Executive Function From a Multiple-intelligences Perspective. J.H. Bernstein, D.P. Waber, Executive Capacities From a Developmental Perspective. K.W. Fischer, S.G. Daley, Connecting Cognitive Science and Neuroscience to Education: Potentials and Pitfalls in Inferring Executive Processes. Part 2. Executive Function Difficulties in Different Diagnostic Groups: Challenges of Identification and Treatment. L. Meltzer, K. Krishnan, Executive Function Difficulties and Learning Disabilities: Understandings and Misunderstandings. J.A. Stein, K. Krishnan, Nonverbal Learning Disabilities and Executive Function: The Challenges of Effective Assessment and Learning. S. Ozonoff, P.L. Schetter, Executive Dysfunction in Autism Spectrum Disorders: From Research to Practice. Part 3. Interventions to Address Executive Function Processes. L. Meltzer, L.S. Pollica, M. Barzillai, Executive Function in the Classroom: Embedding Strategy Instruction into Daily Teaching Practices. I.W. Gaskins, E. Satlow, M. Pressley, Executive Control of Reading Comprehension in the Elementary School. S. Graham, K.R. Harris, N. Olinghouse, Addressing Executive Function Problems in Writing: An Example From the Self-regulated Strategy Development Model. B.N. Roditi, J. Steinberg, The Strategic Math Classroom: Executive Function Processes and Mathematics Learning. I.W. Gaskins, M. Pressley, Teaching Metacognitive Strategies That Address Executive Function Processes Within a Schoolwide Curriculum. D. Rose, K. Rose, Deficits in Executive Function Processes: A Curriculum-based Intervention.
Moving Families: Expatriation, Stress and Coping

1. Introduction 2. Who are they, and why do they move? 3. What is stressful about moving abroad? 4. Strains on families 5. Coping 6. Giving and receiving social support 7. Social support from within the family 8. Effects on children 9. The effect of the move: Two case studies 10. Families two years later 11. Summary and conclusions
TRANSLATION AND COGNITION: METAPHORS IN SPECIALIZED TEXTS

For Aristotle, the metaphor is more than just a rhetorical resource, it is a transposition of meaning from one to that of another. This should not be understood as a simple name change or simple change in meaning either, but an integration or transfer in the meaning of a term, from one meaning to another by means of an image. On the other hand, Lakoff and Johnson (2003) assert that metaphor impregnates everyday life, not only language, but also thought and action. From this perspective, our ordinary conceptual system is fundamentally metaphorical in nature. The objective of this article is to illustrate the way in which specialists use metaphor as a discursive resource, to simplify and explain concepts, allowing them to be understood in a more concrete way. This also approximates concepts to the experience of the reader as well as, expressing them so that they become accessible for the majority of people. (Suarez, 2004) Furthermore, demonstrate how this linguistic phenomenon, in a discourse, is transferred from the original text to the translated text. This work began with the selection of a corpus of parallel texts from the field of psycholinguistics. The selection of the corpus took place under the following criteria: parallelism, singularity of domain and the level of specialty. The data analyzed will yield results of both a qualitative and quantitative nature regarding the changes that take place when translating metaphors. These results significantly support the master's thesis under development within the research line of cognitive processes in translation in the Universidad Autonoma of Manizales in Colombia. Equally, this descriptive work will provide important input to develop the experimental tests that is part of the master´s project previously mentioned.
Achieving success at work: development and validation of the Motivational Climate at Work Questionnaire (MCWQ)

Although work represents an important achievement setting, research on the perceived motivational climate, as defined by the achievement goal theory (AGT), remains limited. Calls have been made for research on the salience of such situational influences based on traditional AGT. Therefore, the aim of this research was to develop a scale to measure the motivational climate at work. In a pilot study, participants completed a developed questionnaire and the findings supported psychometric properties of the questionnaire. Two further studies were conducted and the findings provided evidence of content validity, criterion-related validity, construct validity, and internal consistency. The findings suggest the questionnaire might be used to determine the perception of the extant motivational climate in the workplace.
Agammaglobulinemia and Staphylococcus aureus Botryomycosis in a Cohort of Related Sentinel Swiss Webster Mice

ABSTRACT Sentinel mouse seroconversion to infectious agents is critical for laboratory animal facility disease monitoring. We report spontaneous emergence of non-sex-linked agammaglobulinemia with B-cell deficiency and cutaneous Staphylococcus aureus granulomatosis (botryomycosis) in a cohort of related Swiss Webster sentinel mice. Our experience reinforces the importance of immunocompetency validation in surveillance programs.
Relative Patterns Discovery toward Big Data Analytics

Recently, enterprises and governments invested aggressively in big data analytics because it is truly representative of popular opinion based on millions of people. Despite bringing new opportunities, big data encounters the challenges such as extremely large number of observations (e.g., Millions of transactions), high dimensionality (e.g., Thousands of items), and immediate response. Taking big data into consideration, the conventional association analysis is frustrated by the extraction of patterns information. Specifically, the computational complexity of frequent item sets mining increases exponentially by the number of items, which has been proven to be an NP-Complete problem. Although many studies used a pruning-patterns strategy to reduce the complexity, it probably distorts the shape of data and incurs inaccurate result. In this paper, we introduce relative patterns discovery (named RPD) that explores the same patterns between each two observations. To show that RPD is a pragmatic solution toward big data analytics, we design a scalable outlier detection method (named SOD) based on the concept of RPD. Particularly, SOD can score the anomaly without enumerate all the relative patterns. The empirical investigations, conducted with various real-world datasets, demonstrate that SOD performs well even in the environment of large number of observations and high dimensionality.
Articulatory additions to the classical description of the speech of persons with cleft palate.

: Three types of compensatory articulation used by speakers with cleft palate and velopharyngeal inadequacy are described: the pharyngeal stop, the mid-dorsum palatal stop, and the posterior nasal fricative. These articulatory characteristics have not been previously reported in the literature. Each is defined radiographically to depict deviant place of production. Each is also described in terms of perceptually distinct speech characteristics. Production features of these articulatory compensations are contrasted and compared with those of the glottal stop and pharyngeal fricative. The use of compensatory articulation as replacements for target phonemes is distinguished from their occurrence as aberrant co-articulations with target phonemes. Additionally, phonetic symbols for use in narrow phonetic transcription are presented, and implications for speech remediation are discussed.
Performance Comparison of GaSb, Strained-Si, and InGaAs Double-Gate Ultrathin-Body n-FETs

Using a full-band and atomistic approach based on the nearest-neighbor tight-binding model and the nonequilibrium Green function formalism, (111)/(110) GaSb, (100)/(110) strained-Si, and (100)/(100) In0.53Ga0. 47As n-type double-gate ultrathin-body field-effect transistors designed according to the ITRS specifications for 2020 are simulated in the ballistic limit of transport and with electron-phonon scattering. It is found that, at an equivalent oxide thickness of 0.59 nm, the GaSb device offers the highest ballistic ON-current at a fixed OFF-current, due to the projection to the Γ point of bands originating from the bulk L-valley and possessing a low transport effective mass. It is followed by the strained-Si FET and, finally, the In0.53Ga0. 47As FET, the latter suffering from its small density of states in the channel despite very high electron velocities. However, when electron-phonon scattering is taken into account, the presence of multiple energy subbands, as in GaSb and strained Si, increases the probability of backscattering for electrons; thus, the current of these devices does not exceed that of the In0.53Ga0. 47As FET by more than 13 %.
Metabolomics of Human Cerebrospinal Fluid Identifies Signatures of Malignant Glioma*

Cerebrospinal fluid is routinely collected for the diagnosis and monitoring of patients with neurological malignancies. However, little is known as to how its constituents may change in a patient when presented with a malignant glioma. Here, we used a targeted mass-spectrometry based metabolomics platform using selected reaction monitoring with positive/negative switching and profiled the relative levels of over 124 polar metabolites present in patient cerebrospinal fluid. We analyzed the metabolic profiles from 10 patients presenting malignant gliomas and seven control patients that did not present malignancy to test whether a small sample size could provide statistically significant signatures. We carried out multiple unbiased forms of classification using a series of unsupervised techniques and identified metabolic signatures that distinguish malignant glioma patients from the control patients. One subtype identified contained metabolites enriched in citric acid cycle components. Newly diagnosed patients segregated into a different subtype and exhibited low levels of metabolites involved in tryptophan metabolism, which may indicate the absence of an inflammatory signature. Together our results provide the first global assessment of the polar metabolic composition in cerebrospinal fluid that accompanies malignancy, and demonstrate that data obtained from high throughput mass spectrometry technology may have suitable predictive capabilities for the identification of biomarkers and classification of neurological diseases.
Asymmetric Dimethylarginine in Cerebral Small Vessel Disease

Background and Purpose— Endothelial dysfunction may play a causal role in cerebral small vessel disease (SVD). Asymmetric dimethylarginine (ADMA), a circulating endogenous inhibitor of nitric oxide, has been implicated in endothelial dysfunction, particularly in hyperhomocystinemia, a known risk factor for SVD. We determined if ADMA was elevated in SVD, correlated with disease severity, and interacted with homocysteine. Methods— ADMA and homocysteine levels were determined in 47 consecutive symptomatic SVD patients and 38 controls. SVD was graded by leukoariosis severity and number of lacunar infarcts. Results— Mean (and SD) ADMA was higher in SVD patients compared with controls (0.814 [0.145] versus 0.747 [0.184] &mgr;mol/L; P=0.014) after controlling for age, gender, vascular risk factors, and creatinine clearance. Additionally controlling for homocysteine had only a small effect on this relationship (P=0.055). Mean homocysteine was higher in SVD cases compared with controls (15.14 [5.59] versus 12.49 [4.15] &mgr;mol/L; P=0.035). Leukoariosis grade correlated positively with ADMA (P=0.026) and homocysteine (P=0.003). Lacunar grade correlated with homocysteine (P=0.017), but not ADMA. Conclusions— ADMA is independently associated with SVD and correlates with leukoariosis severity.
Microparticles From Ischemic Muscle Promotes Postnatal Vasculogenesis

Background— We hypothesized that microparticles (MPs) released after ischemia are endogenous signals leading to postischemic vasculogenesis. Methods and Results— MPs from mice ischemic hind-limb muscle were detected by electron microscopy 48 hours after unilateral femoral artery ligation as vesicles of 0.1- to 1-&mgr;m diameter. After isolation by sequential centrifugation, flow cytometry analyses showed that the annexin V+ MP concentration was 3.5-fold higher in ischemic calves than control muscles (1392±406 versus 394±180 annexin V+ MPs per 1 mg; P<0.001) and came mainly from endothelial cells (71% of MPs are CD144+). MPs isolated from ischemic muscles induced more potent in vitro bone marrow–mononuclear cell (BM-MNC) differentiation into cells with endothelial phenotype than those isolated from control muscles. MPs isolated from atherosclerotic plaques were ineffective, whereas those isolated from apoptotic or interleukin-1&bgr;–activated endothelial cells also promoted BM-MNC differentiation. Interestingly, MPs from ischemic muscles produced more reactive oxygen species and expressed significantly higher levels of NADPH oxidase p47 (6-fold; P<0.05) and p67 subunits (16-fold; P<0.001) than controls, whereas gp91 subunit expression was unchanged. BM-MNC differentiation was reduced by 2-fold with MPs isolated from gp91-deficient animals compared with wild-type mice (P<0.05). MP effects on postischemic revascularization were then examined in an ischemic hind-limb model. MPs isolated from ischemic muscles were injected into ischemic legs in parallel with venous injection of BM-MNCs. MPs increased the proangiogenic effect of BM-MNC transplantation, and this effect was blunted by gp91 deficiency. In parallel, BM-MNC proangiogenic potential also was reduced in ABCA1 knockout mice with impaired vesiculation. Conclusion— MPs produced during tissue ischemia stimulate progenitor cell differentiation and subsequently promote postnatal neovascularization.
Adherence to Early Antiretroviral Therapy: Results From HPTN 052, a Phase III, Multinational Randomized Trial of ART to Prevent HIV-1 Sexual Transmission in Serodiscordant Couples

Background: Combination antiretroviral therapy (ART) for HIV-1–infected individuals prevents sexual transmission if viral load is suppressed. Methods: Participants were HIV-1–infected partners randomized to early ART (CD4 350–550) in HPTN052 (n = 886, median follow-up = 2.1 years), a clinical trial of early ART to prevent sexual transmission of HIV-1 in serodiscordant couples at 13 sites in 9 countries. Adherence was assessed through pill count (dichotomized at <95%) and through self-report items. Predictors of adherence were mental health and general health perceptions, substance use, binge drinking, social support, sexual behaviors, and demographics. Viral suppression was defined as HIV plasma viral load <400 copies per milliliter. Adherence counseling and couples' counseling about safer sex were provided. Logistic and linear regression models using generalized estimating equation for repeated measurements were used. Findings: Through pill count, 82% of participants were adherent at 1 month and 83.3% at 1 year. Mental health was the only psychosocial variable associated with adherence [pill count, odds ratios (OR) = 1.05, 95% confidence intervals (CIs): 1.00 to 1.11; self-report parameter estimate, OR = 0.02, 95% CI: 0.01 to 0.04], although regional differences emerged. Pill count (OR = 1.19, 95% CI: 1.10 to 1.30) and self-report (OR = 1.42, 95% CI: 1.14 to 1.77) adherence were associated with viral suppression. Interpretation: Although adherence was high among individuals in stable relationships taking ART for prevention, mental health and adherence covaried. Assessing and intervening on mental health in the context of promoting adherence to ART as prevention should be explored. Adherence and couples' counseling, feedback about viral suppression, and/or altruism may also help explain the magnitude of adherence observed.
Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.

CONTEXT Modafinil, a wake-promoting drug used to treat narcolepsy, is increasingly being used as a cognitive enhancer. Although initially launched as distinct from stimulants that increase extracellular dopamine by targeting dopamine transporters, recent preclinical studies suggest otherwise. OBJECTIVE To measure the acute effects of modafinil at doses used therapeutically (200 mg and 400 mg given orally) on extracellular dopamine and on dopamine transporters in the male human brain. DESIGN, SETTING, AND PARTICIPANTS Positron emission tomography with [(11)C]raclopride (D(2)/D(3) radioligand sensitive to changes in endogenous dopamine) and [(11)C]cocaine (dopamine transporter radioligand) was used to measure the effects of modafinil on extracellular dopamine and on dopamine transporters in 10 healthy male participants. The study took place over an 8-month period (2007-2008) at Brookhaven National Laboratory. MAIN OUTCOME MEASURES Primary outcomes were changes in dopamine D(2)/D(3) receptor and dopamine transporter availability (measured by changes in binding potential) after modafinil when compared with after placebo. RESULTS Modafinil decreased mean (SD) [(11)C]raclopride binding potential in caudate (6.1% [6.5%]; 95% confidence interval [CI], 1.5% to 10.8%; P = .02), putamen (6.7% [4.9%]; 95% CI, 3.2% to 10.3%; P = .002), and nucleus accumbens (19.4% [20%]; 95% CI, 5% to 35%; P = .02), reflecting increases in extracellular dopamine. Modafinil also decreased [(11)C]cocaine binding potential in caudate (53.8% [13.8%]; 95% CI, 43.9% to 63.6%; P < .001), putamen (47.2% [11.4%]; 95% CI, 39.1% to 55.4%; P < .001), and nucleus accumbens (39.3% [10%]; 95% CI, 30% to 49%; P = .001), reflecting occupancy of dopamine transporters. CONCLUSIONS In this pilot study, modafinil blocked dopamine transporters and increased dopamine in the human brain (including the nucleus accumbens). Because drugs that increase dopamine in the nucleus accumbens have the potential for abuse, and considering the increasing use of modafinil, these results highlight the need for heightened awareness for potential abuse of and dependence on modafinil in vulnerable populations.
Praying, Playing, and Successful Families

Abstract The purpose of this study was to examine the relationship between family religiosity, family leisure, and family functioning. The sample consisted of 121 parents and 99 youth from various religious groups. Results indicated a positive relationship between family religiosity and family leisure. Both family religiosity and family leisure had a significant relationship with family functioning in this sample. Data collected from both parents and youth provided insight into the influence of family religiosity and family leisure on family functioning. Family religiosity was the strongest predictor of family functioning for parents. For youth, both family leisure and family religiosity were significant predictors of family functioning. Findings provide specific implications for future family leisure research, as well as for parents and professionals who work with families.
Does the Reporting Quality of Diagnostic Test Accuracy Studies, as Defined by STARD 2015, Affect Citation?

Objective To determine the rate with which diagnostic test accuracy studies that are published in a general radiology journal adhere to the Standards for Reporting of Diagnostic Accuracy Studies (STARD) 2015, and to explore the relationship between adherence rate and citation rate while avoiding confounding by journal factors. Materials and Methods All eligible diagnostic test accuracy studies that were published in the Korean Journal of Radiology in 2011–2015 were identified. Five reviewers assessed each article for yes/no compliance with 27 of the 30 STARD 2015 checklist items (items 28, 29, and 30 were excluded). The total STARD score (number of fulfilled STARD items) was calculated. The score of the 15 STARD items that related directly to the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 was also calculated. The number of times each article was cited (as indicated by the Web of Science) after publication until March 2016 and the article exposure time (time in months between publication and March 2016) were extracted. Results Sixty-three articles were analyzed. The mean (range) total and QUADAS-2-related STARD scores were 20.0 (14.5–25) and 11.4 (7–15), respectively. The mean citation number was 4 (0–21). Citation number did not associate significantly with either STARD score after accounting for exposure time (total score: correlation coefficient = 0.154, p = 0.232; QUADAS-2-related score: correlation coefficient = 0.143, p = 0.266). Conclusion The degree of adherence to STARD 2015 was moderate for this journal, indicating that there is room for improvement. When adjusted for exposure time, the degree of adherence did not affect the citation rate.
Transcriptomic Identification of Drought-Related Genes and SSR Markers in Sudan Grass Based on RNA-Seq

Sudan grass (Sorghum sudanense) is an annual warm-season gramineous forage grass that is widely used as pasture, hay, and silage. However, drought stress severely impacts its yield, and there is limited information about the mechanisms of drought tolerance in Sudan grass. In this study, we used next-generation sequencing to identify differentially expressed genes (DEGs) in the Sudan grass variety Wulate No.1, and we developed simple sequence repeat (SSR) markers associated with drought stress. From 852,543,826 raw reads, nearly 816,854,366 clean reads were identified and used for analysis. A total of 80,686 unigenes were obtained via de novo assembly of the clean reads including 45,065 unigenes (55.9%) that were identified as coding sequences (CDSs). According to Gene Ontology analysis, 31,444 unigenes were annotated, 11,778 unigenes were identified to 25 categories in the clusters of orthologous groups of proteins (KOG) classification, and 11,223 unigenes were assigned to 280 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Additionally, there were 2,329 DEGs under a short-term of 25% polyethylene glycol (PEG) treatment, while 5,101 DEGs were identified under the long-term of 25% PEG treatment. DEGs were enriched in pathways of carbon fixation in photosynthetic organisms and plant hormone signal transduction which played a leading role in short-term of drought stress. However, DEGs were mainly enriched in pathway of plant hormone signal transduction that played an important role under long-term of drought stress. To increase accuracy, we excluded all the DEGs of all controls, specifically, five DEGs that were associated with high PEG concentrations were found through RNA-Seq. All five genes were up-regulated under drought stress, but the functions of the genes remain unclear. In addition, we identified 17,548 SSRs obtained from 80,686 unigenes. The newly identified drought tolerance DEGs will contribute to transgenic breeding efforts, while SSRs developed from high-throughput transcriptome data will facilitate marker-assisted selection for all traits in Sudan grass.