Miracle-dz/UniFAR-FTUs huggingface dataset:
Stabilization of a Class of Switched Linear Neutral Systems Under Asynchronous Switching

This technical note concerns the stabilization problem for a class of switched linear neutral systems in which time delays appear in both the state and the state derivatives. In addition, the switching signal of the switched controller also involves time delays, which makes the switching between the controller and the system asynchronous. Based on a new integral inequality and the piecewise Lyapunov-Krasovskii functional technique, a condition for global uniform exponential stability of the switched neutral system under an average dwell time (ADT) scheme is proposed. Then, the corresponding solvability condition for the controller is established. Finally, a numerical example is given to illustrate the effectiveness of the proposed theory.
Machine learning based small cell cache strategy for ultra dense networks

Caching contents at base stations (BSs) has emerged as an effective way to offload backhaul traffic and improve quality of experience (QoE). Considering the limited cache size, how to maximize cache efficiency has become an urgent issue to be addressed. In this paper, we consider caching selected contents at small cell base stations (SBSs) in ultra dense network (UDN). The cache efficiency problem is formulated as a system backhaul load minimization problem, which is hard to be solved for the highly random content demands. Therefore, machine learning based cache strategies are proposed to tackle this difficult problem from the perspective of exploiting the potential of mobile traffic data. First, K-means clustering algorithm is used to fully uncover hidden spatio-temporal patterns of content requests at SBSs, and achieve personalized inter-cluster cache and predictive intracluster cache. Second, k-Nearest Neighbour (k-NN) classification algorithm is introduced to categorize the constantly emerging new contents and cache them in the corresponding cluster periodically with high accuracy and low complexity. Simulation results demonstrate great superiority of the proposed cache strategies over the existing approach.
Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation

Heart Failure (HF) is associated with increased circulating levels of aldosterone and systemic inflammation. Mineralocorticoid receptor (MR) antagonists block aldosterone action and decrease mortality in patients with congestive HF. However, the molecular mechanisms underlying the therapeutic benefits of MR antagonists remain unclear. MR is expressed in all cell types in the heart, including the endothelial cells (EC), in which aldosterone induces the expression of intercellular adhesion molecule 1 (ICAM‐1). Recently, we reported that ICAM‐1 regulates cardiac inflammation and cardiac function in mice subjected to transverse aortic constriction (TAC). Whether MR specifically in endothelial cells (EC) contributes to the several mechanisms of pathological cardiac remodeling and cardiac dysfunction remains unclear. Basal cardiac function and LV dimensions were comparable in mice with MR selectively deleted from ECs (EC‐MR−/−) and wild‐type littermate controls (EC‐MR+/+). MR was specifically deleted in heart EC, and in EC‐containing tissues, but not in leukocytes of TAC EC‐MR−/− mice. While EC‐MR−/− TAC mice showed preserved systolic function and some alterations in the expression of fetal genes, the proinflammatory cytokine TNFα and the endothelin receptors in the LV as compared to EC‐MR+/+ TAC mice, no difference was observed between both TAC groups in overall cardiac hypertrophy, ICAM‐1 LV expression and leukocyte infiltration, cardiac fibrosis or capillary rarefaction, all hallmarks of pathological cardiac remodeling. Our data indicate that EC‐MR contributes to the transition of cardiac hypertrophy to systolic dysfunction independently of other maladaptive changes induced by LV pressure overload.
Graduate‐Entry Non‐Nursing Students: Is Emotional Intelligence the Difference?

&NA; Despite numerous measures of their success, nurses from graduate nursing programs for non‐nurses (GPNNN) often struggle to find acceptance in the workplace. Employers frequently describe these nurses' superior psycho/social capabilities when compared to traditionally educated nurses, but little substantiating quantitative data exist to support this. This study explored nursing students' psycho/social ability by comparing measured emotional intelligence (EI) ability among students from four nursing schools, including one GPNNN program. Findings included significantly higher scores in the EI subscore “understanding emotions” for GPNNN students over two of the three comparison nursing programs, even when data were controlled for age.
Non-steroidal anti-inflammatory drugs and chronic kidney disease progression: a systematic review.

BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) are widely regarded as one risk factor, which influences chronic kidney disease (CKD) progression. However, previous literature reviews have not quantified the risk in moderate to severe CKD patients. OBJECTIVE To estimate the strength of association between chronic NSAID use and CKD progression. METHODS We conducted a systematic review and meta-analysis of observational general practice or population studies featuring patients aged 45 years and over. The electronic databases searched were MEDLINE, EMBASE, Cochrane, AMED, BNI and CINAHL until September 2011 without date or language restrictions. Searches included the reference lists of relevant identified studies, WEB of KNOWLEDGE, openSIGLE, specific journals, the British Library and expert networks. For relevant studies, random effects meta-analysis was used to estimate the association between NSAID use and accelerated CKD progression (estimated glomerular filtration rate decline ≥ 15 ml/min/1.73 m2). RESULTS From a possible 768 articles, after screening and selection, seven studies were identified (5 cohort, 1 case-control and 1 cross-sectional) and three were included in the meta-analysis. Regular-dose NSAID use did not significantly affect the risk of accelerated CKD progression; pooled odds ratio (OR) = 0.96 (95%CI: 0.86-1.07), but high-dose NSAID use significantly increased the risk of accelerated CKD progression; pooled OR = 1.26 (95%CI: 1.06-1.50). CONCLUSIONS The avoidance of NSAIDs in the medium term is unnecessary in patients with moderate to severe CKD, if not otherwise contraindicated. As the definition of high-dose of NSAID use remains unclear, the lowest effective dose of NSAIDs should be prescribed where indicated.
Developmental differences in episodic memory across school ages: evidence from enacted events performed by self and others

ABSTRACT The aim of this study was to examine action memory as a form of episodic memory among school-aged subjects. Most research on action memory has focused on memory changes in adult populations. This study explored the action memory of children over time. A total of 410 school-aged child participants, comprising 201 girls and 208 boys in four age groups (8, 10, 12, and 14), were included in this study. We studied two forms of action encoding, subject-performed tasks (SPTs) and experimenter-performed tasks (EPTs), which were compared with one verbal encoding task as a control condition. At retrieval, we used three memory tests (free recall, cued recall, and recognition). We observed significant differences in memory performance in children aged 8–14 years with respect to free recall and cued recall but not recognition. The largest memory enhancement was observed for the SPTs in the 8–14-year-old participants under all test conditions. Participants performed equally well on the free recall of SPTs and EPTs, whereas they displayed better performances on the cued recall and recognition of SPTs compared to EPTs. The strategic nature of SPTs and the distinction between item-specific information and relational information are discussed.
Freeze-all embryo strategy in poor ovarian responders undergoing ovarian stimulation for in vitro fertilization

Abstract This retrospective study determined the efficacy of the ‘freeze-all’ embryo strategy in poor ovarian responders undergoing ovarian stimulation for in vitro fertilization (IVF). A total of 559 poor responders who met Bologna criteria between January 2012 and December 2014 were included in this study: 256 in the fresh embryo transfer group and 303 in the freeze-all group. Vitrification and warming of day 3 embryos were performed using the Cryotop method. The poor responders treated with fresh embryo transfer and those treated with freeze-all strategy showed similar live birth rates per cycle (12.1% vs. 16.2%, p = .172) and per transfer (15.9% vs. 20.9%, p = .182). Multivariate logistic regression analysis showed that maternal age at retrieval (odds ratio, 0.919; 95% confidence interval, 0.865–0.977; p = .006) and number of good-quality embryos transferred (odds ratio, 1.953; 95% confidence interval, 1.346–2.835; p < .001) were significantly associated with the live birth rate. Freeze-all cycle is an acceptable treatment in poor ovarian responders, and it should be suggested by physicians as an alternative to cycle cancelation in case in which a fresh transfer would not be advantageous.
A Low-Complexity Detection Scheme for Generalized Spatial Modulation Aided Single Carrier Systems

Generalized spatial modulation (GSM), which combines spatial modulation (SM) and vertical Bell Laboratories layered space-time (V-BLAST), is a novel attractive multi-input multi-output (MIMO) technique. In this letter, a low-complexity near-optimal detection scheme is presented for GSM aided single carrier (SC) transmission over dispersive channels. Compared to the conventional partial interference cancellation receiver with successive interference cancellation (PIC-R-SIC), the proposed scheme offers a near maximum likelihood (ML) detection performance while avoiding complicated matrix operations, which allows it to exhibit a lower computational complexity. Simulation results show that the proposed scheme provides a considerable performance improvement compared to PIC-R-SIC, especially in rank-deficient channels scenarios.
A follow‐up case–control association study of tractable (druggable) genes in recurrent major depression

The High‐Throughput Disease‐specific target Identification Program (HiTDIP) aimed to study case–control association samples for 18 common diseases. Here we present the results of a follow‐up case–control association study of HiTDIP in major depressive disorder (MDD). The HiTDIP in MDD was conducted in a sample of 974 cases of recurrent MDD of white German origin collected at the Max‐Planck Institute (MP‐GSK) and 968 ethnically matched controls screened for lifetime absence of depression. Six genes were identified as of interest for a follow‐up, based on the strength of the association and based on the interest as potential candidate target for developing new treatment for depression: Solute Carrier Family 4 Member 10 (SLC4A10), Dipeptidyl Peptidase IV (DPP4), Dopamine Receptor D3 (DRD3), Zinc Finger Protein 80 (ZNF80), Nitric Oxide Synthase 2A (NOS2A) and Peroxisome Proliferator‐Activated Receptor‐Gamma, Coactivator 1, Alpha (PPARGC1A). Within the current study, we attempted to follow‐up these findings in a sample from the UK, the Depression Case Control (DeCC) sample consisting of 1,196 cases and 842 screened controls, phenotyped using exactly the same methods as the MP‐GSK sample. Performing Cochran–Mantel–Haenzel statistics to test for genotypic and/or allelic differences between the DeCC and MP‐GSK samples, we found no significant differences, thus being able to combine the two samples for association testing. In the combined sample of 2,170 MDD cases and 1,810 controls, there were positive findings in the Nitric Oxide Synthase 2A (NOS2A) gene both using single SNP analysis and haplotype analysis. © 2011 Wiley‐Liss, Inc.
The relationship between the prestellar core mass function and the stellar initial mass function

Stars form from dense molecular cores, and the mass function of these cores (the CMF) is often found to be similar to the form of the stellar initial mass function (IMF). This suggests that the form of the IMF is the result of the form of the CMF. However, most stars are thought to form in binary and multiple systems, therefore the relationship between the IMF and the CMF cannot be trivial. We test two star formation scenarios – one in which all stars form as binary or triple systems, and one in which low-mass stars form in a predominantly single mode. We show that from a log-normal CMF, similar to those observed, and expected on theoretical grounds, the model in which all stars form as multiples gives a better fit to the IMF.
The genus Calea L.: A review on traditional uses, phytochemistry, and biological activities

Calea L. is a genus of shrubs and perennial herbs belonging to Asteraceae family. It is a very well‐known genus, consisting of approximately 125 neotropical species. Calea genus is a rich source of phytochemicals, and some of its species have been used in folk medicine to treat several health problems such as diabetes, arterial hypertension, respiratory and gastrointestinal disorders, gastric ulcers, and inflammation. Many studies have demonstrated the pharmacological potential of this genus, including antinociceptive, antihypertensive, antidiarrheal, antimicrobial, anti‐inflammatory, antidiabetic, antiproliferative, and cytotoxic activities. Moreover, bioactive constituents related to these properties are mainly sesquiterpene lactones and phenolic derivatives. In this review, we compiled the literature data up to December 2016, furnishing a comprehensive survey about medicinal uses, chemistry, and biological activities from Calea species. Bibliographic search was performed in several search engines using “Calea” as search keyword. Further, a manual literature search of references found in the selected studies was also conducted. There was no initial time limit.
The Calculation of Negative Bias Illumination Stress-Induced Instability of Amorphous InGaZnO Thin-Film Transistors for Instability-Aware Design

We propose a systematic calculation method for negative bias illumination stress (NBIS)-induced instabilities in amorphous InGaZnO thin-film transistors (TFTs). The proposed method is based on activation energy window (AEW) in subgap energy range, and it can reproduce the NBIS time evolution of <inline-formula> <tex-math notation="LaTeX">${I}$ </tex-math></inline-formula>–<inline-formula> <tex-math notation="LaTeX">${V}$ </tex-math></inline-formula> characteristics without long-term stress test. Furthermore, it quantitatively explains the effect of oxygen content on the NBIS instability. The AEW, which is employed for emulating the oxygen vacancy ionization, peroxide formation, and hole trapping, has the order of magnitude of 10<sup>16</sup>–10<sup>17</sup> cm<sup>−3</sup> for the bias stress of −20 V and the commercial LED backlight of 300 cd/m<sup>2</sup>. The proposed method is expected to play such an important role in the instability awareness of amorphous oxide TFTs.
Rivaroxaban for treatment of suspected or confirmed heparin‐induced thrombocytopenia study

Essentials Heparin‐induced thrombocytopenia (HIT) is a thrombogenic condition that is difficult to treat. We evaluated rivaroxaban as a treatment option in patients with suspected or confirmed HIT. One patient had recurrent thrombosis and 9/10 patients with thrombocytopenia had platelet recovery. Rivaroxaban may be an effective and safe treatment option for HIT.
Model checking multi-agent systems with MABLE

MABLE is a language for the design and automatic verification of multi-agent systems. MABLE is essentially a conventional imperative programming language, enriched by constructs from the agent-oriented programming paradigm. A MABLE system contains a number of agents, programmed using the MABLE imperative programming language. Agents in MABLE have a mental state consisting of beliefs, desires and intentions. Agents communicate using request and inform performatives, in the style of the fipa agent communication language. MABLE systems may be augmented by the addition of formal claims about the system, expressed using a quantified, linear temporal belief-desire-intention logic. MABLE has been fully implemented, and makes use of the spin model checker to automatically verify the truth or falsity of claims.
Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD−iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3

Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease that reflects a failure to block the production of self-reactive antibodies, especially those that bind double-stranded DNA (dsDNA). Backcrossing the lupus-prone NZM2410 genome onto C57BL/6 led to the identification of three genomic intervals, termed sle1, sle2 and sle3, which are associated with lupus susceptibility. We previously generated a C57BL/6 strain congenic for an immunoglobulin DH locus (ΔD–iD) that enriches for arginine at dsDNA-binding positions. We individually introduced the ΔD–iD allele into the three sle strains to test whether one or more of these susceptibility loci could affect the developmental fate of B cells bearing arginine-enriched CDR-H3s, the CDR-H3 repertoire created by the DH and the prevalence of dsDNA-binding antibodies. We found that the combination of the ΔD–iD allele and the sle1 locus led to a decrease in mature, recirculating B cell numbers and an increase in marginal zone cell numbers while maintaining a highly charged CDR-H3 repertoire. ΔD–iD and sle2 had no effect on peripheral B cell numbers, but the CDR-H3 repertoire was partially normalized. ΔD–iD and sle3 led to an increase in marginal zone B cell numbers, with some normalization of hydrophobicity. Mice with ΔD–iD combined with either sle1 or sle3 had increased production of dsDNA-binding IgM and IgG by 12 months of age. These findings indicate that the peripheral CDR-H3 repertoire can be categorically manipulated by the effects of nonimmunoglobulin genes.
Space and Time in the Child's Mind: Evidence for a Cross-Dimensional Asymmetry

What is the relationship between space and time in the human mind? Studies in adults show an asymmetric relationship between mental representations of these basic dimensions of experience: Representations of time depend on space more than representations of space depend on time. Here we investigated the relationship between space and time in the developing mind. Native Greek-speaking children watched movies of two animals traveling along parallel paths for different distances or durations and judged the spatial and temporal aspects of these events (e.g., Which animal went for a longer distance, or a longer time? ). Results showed a reliable cross-dimensional asymmetry. For the same stimuli, spatial information influenced temporal judgments more than temporal information influenced spatial judgments. This pattern was robust to variations in the age of the participants and the type of linguistic framing used to elicit responses. This finding demonstrates a continuity between space-time representations in children and adults, and informs theories of analog magnitude representation.
Fast and Slow Processes Underlying Theories of Information Technology Use

Although theories of information technology (IT) use have been widely researched, organizations continue to struggle with insufficiently utilizing their IT assets. Those interested in understanding and managing IT use need both novel theoretical development and new directions for future research. In this paper, we address both of these needs. Regarding the first need, we develop novel theory by explaining two types of cognitive processes—one fast and one slow—that underlie theories of IT use. The impetus for our explanation of underlying processes (EUP) comes from studies of IT use that have found moderating effects of previous interaction with IT. With these results, researchers have concluded that cognitions are less important in determining IT use as the use of that IT increases. Consistent with that conclusion, our EUP posits that, as learning from prior use occurs, the influence of fast, automatic, unconscious (type 1) cognitive processes increases while the influence decreases for slow, controlled, conscious (type 2) cognitive processes. Type 1 processes automatically generate a default type 1 response; type 2 processes have the potential to generate an intervening type 2 response. The intervention potential is highest for initial use of the target IT and lowest when learning is high such that use of the IT has become automatic. From our EUP, we develop three insights: 1) that the cognitions that lead to a default response are not necessarily the cognitions found in extant theories of IT use, 2) that both type 1 and type 2 processes are subject to bounded rationality, and 3) that the relationship between learning and the intervention potential for a type 2 response, although negative, may not be linear. To address the second need that we note above, we suggest new directions for future research, which includes investigating the cognitive control problem (i.e., when type 2 processes intervene) and exploring the effects of heuristics, nudges, and bounded rationality on decisions to use IT. Beyond the hope that the suggested directions for research will yield solutions for addressing the underutilization of IT assets, the fundamental advances in theoretical understanding that we present here suggest notable implications for practice, including developing brief, simple, cognitively unconscious messages directed at nudging decision makers toward a default response to use the target IT.
A Single-Point, Multiparameter, Fiber Optic Sensor Based on a Combination of Interferometry and LSPR

We demonstrate a new single-point, multiparameter, fiber optic sensor concept based on a combination of interferometric and plasmonic sensor modalities on an optical fiber end face. The sensor consists of an extrinsic Fabry–Perot interferometer in the form of a hemispherical stimuli-responsive hydrogel with immobilized gold nanoparticles (GNPs). The GNPs exhibit local surface plasmon resonance (LSPR) that is sensitive toward the local refractive index (RI) of the surrounding environment, whereas the stimuli-responsive hydrogel is sensitive toward specific chemical compounds. We evaluate the quality of the interferometric and LSPR signals as a function of GNP concentration and of hydrogel swelling degree stimulated by ethanol solutions. The GNPs have little influence on the visibility of the Fabry–Perot etalon. The swelling degree of the hydrogel, with corresponding bulk RI changes, has little influence on the local surface RI of the GNPs. We expect this novel sensor concept to be of great value for biosensors for medical applications.