Miracle-dz/UniFAR-FTUs huggingface dataset:
miRCancer: a microRNA-cancer association database constructed by text mining on literature

MOTIVATION Research interests in microRNAs have increased rapidly in the past decade. Many studies have showed that microRNAs have close relationships with various human cancers, and they potentially could be used as cancer indicators in diagnosis or as a suppressor for treatment purposes. There are several databases that contain microRNA-cancer associations predicted by computational methods but few from empirical results. Despite the fact that abundant experiments investigating microRNA expressions in cancer cells have been carried out, the results have remain scattered in the literature. We propose to extract microRNA-cancer associations by text mining and store them in a database called miRCancer. RESULTS The text mining is based on 75 rules we have constructed, which represent the common sentence structures typically used to state microRNA expressions in cancers. The microRNA-cancer association database, miRCancer, is updated regularly by running the text mining algorithm against PubMed. All miRNA-cancer associations are confirmed manually after automatic extraction. miRCancer currently documents 878 relationships between 236 microRNAs and 79 human cancers through the processing of >26 000 published articles. AVAILABILITY miRCancer is freely available on the web at http://mircancer.ecu. edu/
Spontaneous Formation of a Proteolytic B1 and B2 Bradykinin Receptor Complex with Enhanced Signaling Capacity*

B1 bradykinin receptor (B1R) induction is critical in the adaptation of the kinin-mediated inflammatory response from a B2 bradykinin receptor (B2R) subtype to a B1R subtype that occurs during chronic insult. Here, we show that B1R spontaneously forms a proteolytic plasma membrane complex with B2R along with increased receptor signaling capacity. Co-expression of hemagglutinin-tagged B2R with FLAG-tagged B1R in HEK293 cells resulted in degradation of B2R as determined by the diminution of the intact 65-kDa B2R species and the appearance of proteolytic B2R products at 30–40 kDa and by the reduction in B2R bradykinin binding sites. On the other hand, the 35-kDa B1R remained intact. Receptor co-expression also led to an increase in constitutive and agonist-stimulated receptor signaling. Selective immunoprecipitation with epitope-specific antibodies revealed a spontaneously formed heterologous receptor complex, which was composed of the intact 35-kDa B1R and the B2R degradation products. Cellular fractionation, cell surface biotinylation, and immunoelectron microscopy showed that B2R·B1R complexes were present on the cell surface. This is the first evidence that a heterologous G protein-coupled receptor complex in the plasma membrane is linked to proteolytic degradation of a participating receptor, and this mechanism may contribute to the adaptation of the kinin response from a B2 type to a B1 type during chronic insult.
Barrier effects of roads on movements of small mammals

�A b s t r a c t. Roads and highways represent one of the most important anthropogenic impacts on natural areas and contribute to habitat fragmentation, because they are linear features that can inhibit animal movement, thereby causing barrier effects by subdividing the populations adjacent to the roads. The study presented here aims to determine, to which extent roads act as a barrier, subdividing populations of three species of small forest mammals: bank vole, yellow-necked mouse and common shrew, and what is the relative importance of road width and traffic intensity on the barrier effect. The study was carried out at four �25 m long segments of roads, close to the city of ceske Budějovice. All segments crossed a forest. The capture-recapture method was applied to determine the crossing rates of animals. The traps were checked three times each day during four consecutive nights, in summer and in autumn. We found that: (�) roads strongly prevent crossing movements in all three studied species, (2) there are interspecific differences in road crossing rates, (3) species cross more often narrow than wide roads, (4) traffic intensity does not affect the crossing rates.
The attack of free radicals on biologically active DNA in irradiated aqueous solutions.

DNA isolated from the bacteriophage ΦX174 was irradiated with γ-rays in a solution of pH 7.0 buffered with 0.01 M phosphate. At concentrations of a few milligrams per milliliter the yield of inactivation is 1.9 molecules of DNA per 100 eV of absorbed energy. The radio-sensitivity in oxygen and nitrogen does not differ significantly. Bubbling with nitrous oxide increases the yield by a factor of 2. These yields were derived from measurements of the 37% survival dose as a function of DNA concentration. Potassium iodide is strongly protective. Because potassium iodide scavenges OH radicals whereas nitrous oxide converts hydrated electrons into OH radicals, it is concluded that in concentrated DNA solutions at least 95% of the inactivations are due to primary attack by OH radicals, although reducing radicals are not completely inactive. At concentrations of a few micrograms per milliliter the yield of inactivation is lower by an order of magnitude and reducing radicals are relatively more important. From the .
A New Efficient Privacy-Preserving Scalar Product Protocol

Recently, privacy issues have become important in data analysis, especially when data is horizontally partitioned over several parties. In data mining, the data is typically represented as attribute-vectors and, for many applications, the scalar (dot) product is one of the fundamental operations that is repeatedly used. In privacy-preserving data mining, data is distributed across several parties. The efficiency of secure scalar products is important, not only because they can cause overhead in communication cost, but dot product operations also serve as one of the basic building blocks for many other secure protocols. Although several solutions exist in the relevant literature for this problem, the need for more efficient and more practical solutions still remains. In this paper, we present a very efficient and very practical secure scalar product protocol. We compare it to the most common scalar product protocols. We not only show that our protocol is much more efficient than the existing ones, we also provide experimental results by using a real life dataset.
New Onset, Aggravation and Recurrence of Crohn's Disease upon Treatment with Three Different Tumor Necrosis Factor Inhibitors

Tumor necrosis factor (TNF) is a major cytokine in the pathogenesis of inflammatory bowel disease (IBD), and TNF inhibition is a cornerstone of contemporary IBD therapy. However, paradoxical induction of IBD has recently been reported upon treatment of rheumatologic disorders with TNF inhibitors. In previous cases, induction of IBD was associated with one single drug and IBD was successfully managed by switching TNF inhibitors. We report the case of a patient with juvenile rheumatoid arthritis under long-term treatment with etanercept. After switching TNF inhibition to adalimumab, symptoms of Crohn's disease (CD) occurred and the diagnosis of CD was established by endoscopy. Further treatment with adalimumab and subsequently infliximab aggravated the abdominal symptoms, necessitating ileocecal resection, after which symptoms resolved for several months. Etanercept treatment due to recurrent rheumatologic symptoms was followed by recurrent CD symptoms and findings, which resolved upon discontinuation of etanercept. This case suggests that induction, aggravation and recurrence of IBD can be rare class effects of TNF inhibition.
Pricing Long-Maturity Equity and FX Derivatives with Stochastic Interest Rates and Stochastic Volatility

In this paper we extend the stochastic volatility model of Schöbel and Zhu (1999) by including stochastic interest rates. Furthermore we allow all driving model factors to be instantaneously correlated with each other, i.e. we allow for a correlation between the instantaneous interest rates, the volatilities and the underlying stock returns. By deriving the characteristic function of the log-asset price distribution, we are able to price European stock options in closed-form by Fourier inversion. Furthermore we present a Foreign Exchange generalization and show how the pricing of Forward-starting options like cliquets can be performed. Additionally we discuss the practical implementation of these new models.
On the Spatial Foundations of the Conceptual System and Its Enrichment

A theory of how concept formation begins is presented that accounts for conceptual activity in the first year of life, shows how increasing conceptual complexity comes about, and predicts the order in which new types of information accrue to the conceptual system. In a compromise between nativist and empiricist views, it offers a single domain-general mechanism that redescribes attended spatiotemporal information into an iconic form. The outputs of this mechanism consist of types of spatial information that we know infants attend to in the first months of life. These primitives form the initial basis of concept formation, allow explicit preverbal thought, such as recall, inferences, and simple mental problem solving, and support early language learning. The theory details how spatial concepts become associated with bodily feelings of force and trying. It also explains why concepts of emotions, sensory concepts such as color, and theory of mind concepts are necessarily later acquisitions because they lack contact with spatial descriptions to interpret unstructured internal experiences. Finally, commonalities between the concepts of preverbal infants and nonhuman primates are discussed.
Impairment of the perception of second order motion but not first order motion in a patient with unilateral focal brain damage

Unlike first order motion, which is based on spatiotemporal variations in luminance, second-order motion relies on spatiotemporal variation of attributes derived from luminance, such as contrast. Here we show that a patient with a small unilateral cortical lesion adjacent to human cortical area MT (V5) has an apparently permanent disorder in perceiving several forms of second-order but not first-order motion in his contralateral visual field. This result indicates that separate pathways for motion perception exist, either as divergent pathways from area MT or even from prim ary visual cortex, or as separate pathways from subcortical areas to extrastriate visual areas.
Evaluating network processing efficiency with processor partitioning and asynchronous I/O

Applications requiring high-speed TCP/IP processing can easily saturate a modern server. We and others have previously suggested alleviating this problem in multiprocessor environments by dedicating a subset of the processors to perform network packet processing. The remaining processors perform only application computation, thus eliminating contention between these functions for processor resources. Applications interact with packet processing engines (PPEs) using an asynchronous I/O (AIO) programming interface which bypasses the operating system. A key attraction of this overall approach is that it exploits the architectural trend toward greater thread-level parallelism in future systems based on multi-core processors. In this paper, we conduct a detailed experimental performance analysis comparing this approach to a best-practice configured Linux baseline system.We have built a prototype system implementing this architecture, ETA+AIO (Embedded Transport Acceleration with Asynchronous I/O), and ported a high-performance web-server to the AIO interface. Although the prototype uses modern single-core CPUs instead of future multi-core CPUs, an analysis of its performance can reveal important properties of this approach. Our experiments show that the ETA+AIO prototype has a modest advantage over the baseline Linux system in packet processing efficiency, consuming fewer CPU cycles to sustain the same throughput. This efficiency advantage enables the ETA+AIO prototype to achieve higher peak throughput than the baseline system, but only for workloads where the mix of packet processing and application processing approximately matches the allocation of CPUs in the ETA+AIO system thereby enabling high utilization of all the CPUs. Detailed analysis shows that the efficiency advantage of the ETA+AIO prototype, which uses one PPE CPU, comes from avoiding multiprocessing overheads in packet processing, lower overhead of our AIO interface compared to standard sockets, and reduced cache misses due to processor partitioning.
Concavity of mutual information rate of finite-state channels

The computation of the capacity of a finite-state channel (FSC) is a fundamental and long-standing open problem in information theory. The capacity of a memoryless channel can be effectively computed via the classical Blahut-Arimoto algorithm (BAA), which, however, does not apply to a general FSC. Recently Vontobel et al. [1] generalized the BAA to compute the capacity of a finite-state machine channel with a Markovian input. Their proof of the convergence of this algorithm, however, depends on the concavity conjecture posed in their paper. In this paper, we confirm the concavity conjecture for some special FSCs. On the other hand, we give examples to show that the conjecture is not true in general.
Multiple Location Profiling for Users and Relationships from Social Network and Content

Users' locations are important for many applications such as personalized search and localized content delivery. In this paper, we study the problem of profiling Twitter users' locations with their following network and tweets. We propose a multiple location profiling model (MLP), which has three key features: 1) it formally models how likely a user follows another user given their locations and how likely a user tweets a venue given his location, 2) it fundamentally captures that a user has multiple locations and his following relationships and tweeted venues can be related to any of his locations, and some of them are even noisy, and 3) it novelly utilizes the home locations of some users as partial supervision. As a result, MLP not only discovers users' locations accurately and completely, but also "explains" each following relationship by revealing users' true locations in the relationship. Experiments on a large-scale data set demonstrate those advantages. Particularly, 1) for predicting users' home locations, MLP successfully places 62% users and out-performs two state-of-the-art methods by 10% in accuracy, 2) for discovering users' multiple locations, MLP improves the baseline methods by 14% in recall, and 3) for explaining following relationships, MLP achieves 57% accuracy.
TRANSFORMATION REACTIONS BETWEEN PNEUMOCOCCUS AND THREE STRAINS OF STREPTOCOCCI

Reciprocal transformation reactions to streptomycin resistance have been demonstrated between pneumococcus and 2 strains of viridans streptococci, which by the usual bacteriological criteria are distantly related to pneumococcus. Desoxyribonucleic acid (DNA) extracts of a strain of streptomycin-resistant Streptococcus salivarius have been found capable of transforming pneumococcus and two strains of viridans streptococci but the strain itself was not transformed by autologous or heterologous DNA extracts. The two strains of viridans streptococci were more efficient than pneumococcus as receptors of both autologous and heterologous transforming principles. It is inferred, therefore, that efficiency of transformation does not necessarily indicate closeness of relationship among bacteria. The efficiency of transforming principles (TP's) from three streptococcal strains to induce streptomycin resistance in pneumococcus increased following their reduplication in pneumococcus. At the same time the efficiency of two of these TP's to transform streptococcus was reduced. Resistance to optochin (ethylhydrocupreine), a characteristic of most streptococci, can be transferred to pneumococcus, a naturally susceptible species, by transformation reactions.
Three Dimensional Miniplates In Management Of Mandibular Fractures

The management of mandibular fractures has seen advancements over time, ranging from different techniques such as wiring, splinting, intermaxillary fixation, rigid fixation, compression plates, and mini plates. However, in all these approaches, there remains a risk of potential infection, need of intermaxillary fixation and improper healing at the site of mandibular fractures. Therefore, in our study, we employed three-dimensional titanium miniplates to secure and stabilize the mandibular fracture site. The use of 3D stainless steel miniplates demonstrated superior stability, fixation, and adaptability, resulting in more favorable outcomes compared to traditional miniplates.
Physiological, Biochemical, and Molecular Mechanisms of Heat Stress Tolerance in Plants

High temperature (HT) stress is a major environmental stress that limits plant growth, metabolism, and productivity worldwide. Plant growth and development involve numerous biochemical reactions that are sensitive to temperature. Plant responses to HT vary with the degree and duration of HT and the plant type. HT is now a major concern for crop production and approaches for sustaining high yields of crop plants under HT stress are important agricultural goals. Plants possess a number of adaptive, avoidance, or acclimation mechanisms to cope with HT situations. In addition, major tolerance mechanisms that employ ion transporters, proteins, osmoprotectants, antioxidants, and other factors involved in signaling cascades and transcriptional control are activated to offset stress-induced biochemical and physiological alterations. Plant survival under HT stress depends on the ability to perceive the HT stimulus, generate and transmit the signal, and initiate appropriate physiological and biochemical changes. HT-induced gene expression and metabolite synthesis also substantially improve tolerance. The physiological and biochemical responses to heat stress are active research areas, and the molecular approaches are being adopted for developing HT tolerance in plants. This article reviews the recent findings on responses, adaptation, and tolerance to HT at the cellular, organellar, and whole plant levels and describes various approaches being taken to enhance thermotolerance in plants.
Psychological Differences Between Children With and Without Soiling Problems

OBJECTIVES. Previous studies, based on clinic samples, report that childhood soiling is associated with behavior problems and reduced self-esteem. This population-based study investigates the prevalence of psychological problems associated with childhood soiling. METHODS. A total of 8242 children aged 7–8 years born to mothers in the United Kingdom–based Avon Longitudinal Study of Parents and Children were studied. Parents completed postal questionnaires assessing common childhood emotional and behavioral problems, and children were asked questions at a research clinic concerning their behavior, friendships, bullying, and self-esteem. The rate of psychological problems was compared in children who soil frequently (once a week or more), those who soil occasionally (less than once a week), and those with no soiling problems (controls). Analyses were adjusted for developmental delay, gender, sociodemographic background, and stressful life events. RESULTS. Children who soil were reported by their parents to have significantly more emotional and behavioral problems compared with children who do not soil. Children who soil frequently had significantly more problems than those who soil occasionally. The rate of attention and activity problems, obsessions and compulsions, and oppositional behavior was particularly high in frequently soiling children. Children with soiling problems reported significantly higher rates of involvement in overt bullying (as both perpetrator and victim) and antisocial activities compared with controls. CONCLUSIONS. The current study finds significantly higher rates of behavior and emotional problems, bullying, and antisocial activities in children who soil compared with those who do not soil. Children who soil frequently are more likely to have these problems than those who soil occasionally.
Physical activity and brain plasticity in late adulthood

The human brain shrinks with advancing age, but recent research suggests that it is also capable of remarkable plasticity, even in late life. In this review we summarize the research linking greater amounts of physical activity to less cortical atrophy, better brain function, and enhanced cognitive function, and argue that physical activity takes advantage of the brain's natural capacity for plasticity. Further, although the effects of physical activity on the brain are relatively widespread, there is also some specificity, such that prefrontal and hippocampal areas appear to be more influenced than other areas of the brain. The specificity of these effects, we argue, provides a biological basis for understanding the capacity for physical activity to influence neurocognitive and neuropsychiatric disorders such as depression. We conclude that physical activity is a promising intervention that can influence the endogenous pharmacology of the brain to enhance cognitive and emotional function in late adulthood.
Advancements and Challenges in Non-Invasive Electrocardiography for Prenatal, Intrapartum, and Postnatal Care: A Comprehensive Review

Non-invasive electrocardiography (NI-ECG) has become an indispensable tool for monitoring fetal and neonatal cardiac activity throughout the stages of pregnancy and postpartum care. This review emphasizes the distinct advantages of NI-ECG, including extended monitoring capabilities and valuable insights into fetal and neonatal health. The exploration of textile electrodes is highlighted as a promising alternative, offering improved comfort and reduced skin irritation compared to traditional adhesive electrodes. However, challenges in NI-ECG persist, with electrode placement, quantity, and noise removal being key considerations. The review underscores the significance of addressing interference sources, such as maternal and fetal body signals, motion artifacts, and electrode-skin contact. Additionally, the discussion extends to computer-aided diagnostics, presenting novel approaches for classifying fetal and neonatal health during pregnancy and delivery. Ongoing research aims to optimize electrode placement, develop advanced noise reduction algorithms, and explore sophisticated classification methodologies. These advancements hold the potential to enhance electronic monitoring, enabling early detection of abnormalities and promoting improved outcomes in prenatal and neonatal care.
Thermal model and analysis of wound rotor induction machine

This paper presents a simplified thermal model for a wound rotor induction machine. The thermal model is based on lumped parameters and the analytical equations for their computation are provided in the paper. The procedures for the thermal model set up have been discussed and validated on a 3.8 hp wound rotor machine, comparing the predicted and measured temperature. Due to the complex cooling system adopted for the tested machine, the techniques for its modeling have also been reported and discussed. The accuracy of the proposed thermal model with a less than 7 percent incidence of error is considered more than reasonable, taking into account the complexity of the system under analysis.