Miracle-dz/UniFAR-FTUs huggingface dataset:
Estimation of the energy loss at the blades in rowing: Common assumptions revisited

Abstract In rowing, power is inevitably lost as kinetic energy is imparted to the water during push-off with the blades. Power loss is estimated from reconstructed blade kinetics and kinematics. Traditionally, it is assumed that the oar is completely rigid and that force acts strictly perpendicular to the blade. The aim of the present study was to evaluate how reconstructed blade kinematics, kinetics, and average power loss are affected by these assumptions. A calibration experiment with instrumented oars and oarlocks was performed to establish relations between measured signals and oar deformation and blade force. Next, an on-water experiment was performed with a single female world-class rower rowing at constant racing pace in an instrumented scull. Blade kinematics, kinetics, and power loss under different assumptions (rigid versus deformable oars; absence or presence of a blade force component parallel to the oar) were reconstructed. Estimated power losses at the blades are 18% higher when parallel blade force is incorporated. Incorporating oar deformation affects reconstructed blade kinematics and instantaneous power loss, but has no effect on estimation of power losses at the blades. Assumptions on oar deformation and blade force direction have implications for the reconstructed blade kinetics and kinematics. Neglecting parallel blade forces leads to a substantial underestimation of power losses at the blades.
ROS: an open-source Robot Operating System

—This paper gives an overview of ROS, an open-source robot operating system. ROS is not an operating system in the traditional sense of process management and scheduling; rather, it provides a structured communications layer above the host operating systems of a heterogenous compute cluster. In this paper, we discuss how ROS relates to existing robot software frameworks, and brieﬂy overview some of the available application software which uses ROS.
Atlas of the Irish rural landscape

This is a major update of this bestselling work on the Irish landscape. When it appeared in 1997, it was instantly hailed as a pioneering volume in increasing appreciation of the Irish landscape as a crucial component of national heritage. The sumptuous quality of its design, the cutting edge cartography, and the clarity of its prose ensured that it became an award-winning volume, widely praised inter-nationally as one of the best books ever to appear on a national landscape. This second edition is far from a cosmetic reissue. At least one-third of the content is entirely new. This includes a complete rewriting of the contemporary section to take account of the Celtic Tiger, and there are six fresh regional case studies - Tory island (Donegal), the Wicklow uplands, Inistiogue (County Kilkenny), Aughris (County Sligo), Clonfert (County Galway) and Point Lance in Newfoundland. There is a new cover, many new maps and photographs, a listing of the top fifty books on the Irish landscape, and a guide to the best websites. "The Atlas of Irish Rural Landscape" is a magnificently illustrated, beautifully written and pioneering introduction to the hidden riches of the Irish landscape. Topics include archaeology, field and settlement patterns, houses, demesnes, villages and small towns, monuments, woodland, bogs, roads, canals, railways, mills, mines, farmsteads, handball alleys, and a host of other features. The Atlas combines superbly chosen illustrations and cartography with a text amenable to a general reader. Hundreds of maps, diagrams, photographs, paintings allow the Atlas to present a mass of scholarly information in an accessible way, suitable for any school, college or home. "The Atlas of the Irish Rural Landscape" also has a significant practical dimension. It increases the visibility of the landscape within national heritage and establishes a proper basis for conservation and planning. It explores contemporary changes resulting from the Celtic Tiger, and proposes how to implement necessary change in sympathy with inherited landscape character.
XML Documents Clustering Using Tensor Space Model -- A Preliminary Study

A hierarchical structure is used to represent the content of the semi-structured documents such as XML and XHTML. The traditional Vector Space Model (VSM) is not sufficient to represent both the structure and the content of such web documents. Hence in this paper, we introduce a novel method of representing the XML documents in Tensor Space Model (TSM) and then utilize it for clustering. Empirical analysis shows that the proposed method is scalable for a real-life dataset as well as the factorized matrices produced from the proposed method helps to improve the quality of clusters due to the enriched document representation with both the structure and the content information.
Requirement engineering elicitation methods: A Kuwaiti empirical study about familiarity, usage and perceived value

Purpose – The purpose of this paper is to investigate the perceptions of 19 requirement engineering (RE) techniques in Kuwait in term of three criteria “awareness,” “use,” and “perceived value generated over past system development projects. ” Also, this paper aims to examine possible relationships between these RE techniques and two information system development success factors.Design/methodology/approach – This paper develops a questionnaire and tests with a sample of respondents from 175 organizations in Kuwait.Findings – Results show that: Arab culture influence perception of RE techniques; most companies have good knowledge of different techniques; several different techniques for identifying and analyzing customer requirements are used; the most highly valued RE techniques are decision trees, goal oriented, prototyping, data flow diagram (DFD), and interviews; six techniques (tree analysis, role playing, unified modeling language, Kawakita Jiro method, flow charts, and Ishikawa) are found to have th.
GPS‐derived strain rate field within the boundary zones of the Eurasian, African, and Arabian Plates

We use the GPS velocity field (1988–1998) for eastern Mediterranean and Asia Minor to determine the crustal deformation strain rate field in an area bounded by 35°N and 43°N, and 20°E and 48°E. We calculate the normal and shear strain rate components associated with the major faults and compare these qualitatively with seismological data. Uncertainties in the calculation of the strain rates reach 50 nstrain yr−1 in sparsely observed parts of Anatolia, whereas we estimate errors <20 nstrain yr−1 in the Aegean and Marmara regions. The largest compressional strain rate components in the eastern part of the study area occur along the Greater Caucasus mountain front reaching 70 nstrain yr−1. (1 nstrain yr−1 = 0.0317 × 10−15 s−1). The North Anatolian Fault Zone is the clearest feature in the shear strain rate field. It is expressed as a pronounced dextral strike-slip fault zone, reaching rates of up to 170 nstrain yr−1. This holds true also for the Izmit area, where the August 17, 1999, earthquake occurred. Central Anatolia is almost strain-free, whereas extension prevails in western Anatolia. The principal axes of extension vary around the N-S direction with strain rates of up to 85 nstrain yr−1. These extensional areas coincide with graben features and normal faulting earthquakes. The central and southwestern Aegean Sea is strain-free with values far below 40 nstrain yr−1. The seismic cluster around the Dodekanissa islands, southeastern Aegean Sea, coincides with NW-SE oriented extension, attaining strain rates of up to 90 nstrain yr−1. This area of extension also exhibits recent active volcanism. The entire Hellenic arc shows compressional strain rates perpendicular to the arc. The Pliny-Strabo troughs along the eastern segment of the arc show left-lateral shear strain rates reaching 80 nstrain yr−1. Significant extension is found in central Greece, with a NNE-SSW oriented maximum of 120 nstrain yr−1 centered around the Gulf of Corinthos. The Kephalonia Fault Zone in NW Greece is a distinct dextral fault zone, separating Apulia from the rapidly moving Aegean microplate. Right-lateral shear strain rates reach 150 nstrain yr−1.
The leaching of salts from saline heavy clay soils. factors affecting the leaching process.

Cracks in dry saline montmorillonitic clay allow the soil to wet rapidly when flooded with negligible redistribution of salts. Once closed the only effective pathways remaining for the movement of leaching water are old root channels and faunal burrows. However, their effectiveness in conducting water and for leaching is severely restricted because of the lack of horizontal connections between them. Restructuring of clay can introduce sufficient permeability to a depth of about 0.7 to 0.8 m to allow salt to be leached provided that the soil's initial moisture content is sufficiently large to prevent disintegration upon wetting (about 24%) and that the clay is not allowed to become unsaturated during the leaching.
Reasoning With Characteristic Models

Formal AI systems traditionally represent knowledge using logical formulas. We will show, however, that for certain kinds of information, a model-based representation is more compact and enables faster reasoning than the corresponding formula-based representation. The central idea behind our work is to represent a large set of models by a subset of characteristic models. More specifically, we examine model-based representations of Horn theories, and show that there are large Horn theories that can be exactly represented by an exponentially smaller set of characteristic models. In addition, we will show that deduction based on a set of characteristic models takes only linear time, thus matching the performance using Horn, theories. More surprisingly, abduction can be performed in polynomial time using a set of characteristic models, whereas abduction using Horn theories is NP-complete.
An analysis of precipitation data from the Antarctic base Faraday/Vernadsky

A recent study on cloud observations reports an increase in total cloud cover at Faraday/Vernadsky since 1960 in the annual and wintertime data. The aim of this present study is to investigate whether this increase in total cloud cover has influenced the precipitation in this region. For this purpose, precipitation observations at the Antarctic base Faraday/Vernadsky between 1960 and 1999 were analysed. A positive trend, significant at the 5% level, was found in the number of precipitation events recorded during winter, showing an increase of 13 events per decade. The annual number of precipitation days has increased by 5.7 per decade during the period of investigation, with highest increase rates being observed in winter and autumn. The characteristics of these findings confirm that results previously published though trends presented here are ∼50% smaller due to a more thorough data quality control of the observational data. These results indicate that an increase in total cloud cover at Faraday/Vernadsky observed since 1960 in the annual and wintertime data is reflected in higher numbers of precipitation events and days. Analyses of the precipitation type found an increase in the proportion of events of non‐frozen precipitation, which is significant (1% level) on an annual basis as well as in spring and autumn (both significant at 5% level). This is a clear manifestation of the year round temperature increase observed over the Antarctic Peninsula. The increase in non‐frozen precipitation will have reduced the albedo in the region and will thus have contributed to the temperature‐albedo feedback. To refreeze rain that is draining through glaciers energy is extracted from the surrounding ice, thereby physically corroding the ice. This will have contributed to the observed retreat of glaciers around the Antarctic Peninsula. As non‐frozen precipitation falling on frozen ground cannot be stored but instead runs off, less water will be available for the ecosystem. Copyright © 2010 Royal Meteorological Society
Cellular Pharmacodynamics of the Novel Biaryloxazolidinone Radezolid: Studies with Infected Phagocytic and Nonphagocytic cells, Using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila

ABSTRACT Radezolid is a novel biaryloxazolidinone in clinical development which shows improved activity, including against linezolid-resistant strains. In a companion paper (29), we showed that radezolid accumulates about 11-fold in phagocytic cells, with ∼60% of the drug localized in the cytosol and ∼40% in the lysosomes of the cells. The present study examines its activity against (i) bacteria infecting human THP-1 macrophages and located in different subcellular compartments (Listeria monocytogenes, cytosol; Legionella pneumophila, vacuoles; Staphylococcus aureus and Staphylococcus epidermidis, mainly phagolysosomal), (ii) strains of S. aureus with clinically relevant mechanisms of resistance, and (iii) isogenic linezolid-susceptible and -resistant S. aureus strains infecting a series of phagocytic and nonphagocytic cells. Radezolid accumulated to similar levels (∼10-fold) in all cell types (human keratinocytes, endothelial cells, bronchial epithelial cells, osteoblasts, macrophages, and rat embryo fibroblasts). At equivalent weight concentrations, radezolid proved consistently 10-fold more potent than linezolid in all these models, irrespective of the bacterial species and resistance phenotype or of the cell type infected. This results from its higher intrinsic activity and higher cellular accumulation. Time kill curves showed that radezolid's activity was more rapid than that of linezolid both in broth and in infected macrophages. These data suggest the potential interest of radezolid for recurrent or persistent infections where intracellular foci play a determinant role.
Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype

Metabolic flexibility might be particularly constrained in tumors bearing mutations in isocitrate dehydrogenase 1 (IDH1) leading to the production of the oncometabolite 2-hydroxygluratate (2HG). To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic intervention, we utilized an MCF10A cell line engineered with an arginine-to-histidine conversion at position 132 (R132H) in the catalytic site of IDH1, which equips the enzyme with a neomorphic α-ketoglutarate to 2HG reducing activity in an otherwise isogenic background. IDH1 R132H/+ and isogenic IDH1 +/+ parental cells were screened for their ability to generate energy-rich NADH when cultured in a standardized high-throughput Phenotype MicroArrayplatform comprising >300 nutrients. A radical remodeling of the metabotype occurred in cells carrying the R132H mutation since they presented a markedly altered ability to utilize numerous carbon catabolic fuels. A mitochondria toxicity-screening modality confirmed a severe inability of IDH1-mutated cells to use various carbon substrates that are fed into the electron transport chain at different points. The mitochondrial biguanide poisons, metformin and phenformin, further impaired the intrinsic weakness of IDH1-mutant cells to use certain carbon-energy sources. Additionally, metabolic reprogramming of IDH1-mutant cells increased their sensitivity to metformin in assays of cell proliferation, clonogenic potential, and mammosphere formation. Targeted metabolomics studies revealed that the ability of metformin to interfere with the anaplerotic entry of glutamine into the tricarboxylic acid cycle could explain the hypersensitivity of IDH1-mutant cells to biguanides. Moreover, synergistic interactions occurred when metformin treatment was combined with the selective R132H-IDH1 inhibitor AGI-5198. Together, these results suggest that therapy involving the simultaneous targeting of metabolic vulnerabilities with metformin, and 2HG overproduction with mutant-selective inhibitors (AGI-5198-related AG-120 [Agios]), might represent a worthwhile avenue of exploration in the treatment of IDH1-mutated tumors.
Brain Activity of Thioctic Acid Enantiomers: In Vitro and in Vivo Studies in an Animal Model of Cerebrovascular Injury

Oxidative stress is an imbalance between the production of free radicals and antioxidant defense mechanisms, potentially leading to tissue damage. Oxidative stress has a key role in the development of cerebrovascular and/or neurodegenerative diseases. This phenomenon is mainly mediated by an enhanced superoxide production by the vascular endothelium with its consequent dysfunction. Thioctic, also known as alpha-lipoic acid (1,2-dithiolane-3-pentanoic acid), is a naturally occurring antioxidant that neutralizes free radicals in the fatty and watery regions of cells. Both the reduced and oxidized forms of the compound possess antioxidant ability. Thioctic acid has two optical isomers designated as (+)- and (−)-thioctic acid. Naturally occurring thioctic acid is the (+)-thioctic acid form, but the synthetic compound largely used in the market for stability reasons is a mixture of (+)- and (−)-thioctic acid. The present study was designed to compare the antioxidant activity of the two enantiomers versus the racemic form of thioctic acid on hydrogen peroxide-induced apoptosis in a rat pheochromocytoma PC12 cell line. Cell viability was evaluated by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and free oxygen radical species (ROS) production was assessed by flow cytometry. Antioxidant activity of the two enantiomers and the racemic form of thioctic acid was also evaluated in spontaneously hypertensive rats (SHR) used as an in vivo model of increased oxidative stress. A 3-h exposure of PC12 cells to hydrogen peroxide (H2O2) significantly decreased cell viability and increased levels of intracellular ROS production. Pre-treatment with racemic thioctic acid or (+)-enantiomer significantly inhibited H2O2-induced decrease in cell viability from the concentration of 50 μmol/L and 20 μmol/L, respectively. Racemic thioctic acid and (+)-salt decreased levels of intracellular ROS, which were unaffected by (−)-thioctic acid. In the brain of SHR, the occurrence of astrogliosis and neuronal damage, with a decreased expression of neurofilament 200 kDa were observed. Treatment of SHR for 30 days with (+)-thioctic acid reduced the size of astrocytes and increased the neurofilament immunoreaction. The above findings could contribute to clarify the role played by thioctic acid in central nervous system injury related to oxidative stress. The more pronounced effect of (+)-thioctic acid observed in this study may have practical therapeutic implications worthy of being investigated in further preclinical and clinical studies.
Torque teno virus DNA titre elevated in idiopathic pulmonary fibrosis with primary lung cancer

Background and objective: IPF is an independent risk factor for lung cancer, but the mechanism of this association has not fully been elucidated. The role of Torque teno virus (TTV) in respiratory disease is poorly understood, although it has been shown that infection with TTV is associated with the activity and prognosis of IPF. This study aimed to investigate the prevalence and titre of TTV DNA among patients with IPF and lung cancer.
The Nei's standard genetic distance in artificial evolution

In recent years, not only ruggedness but also neutrality has been recognized as an important feature of a fitness landscape for genetic search. Following that the concept of neutrality in artificial evolution originates from Kimura's neutral theory in natural evolution, it is expected that the dynamics of artificial evolution in the landscapes including neutrality would be described by using techniques in population genetics. Furthermore, new theoretical guidelines might be developed for effective genetic search. In a recent paper, we have discussed the use of the Nei's standard genetic distance, which originates from population genetics, for measuring neutrality of fitness landscapes. In our results, several consistencies with the population genetics have been found by applying the Nei's standard genetic distance to a tunably neutral NK landscape. Computer simulations are systematically conducted by using a standard genetic algorithm in order to clarify the characteristics of the Nei's standard genetic distance. The terraced NK landscape is adopted as a test function.
Mechanisms of clonal abortion tolerogenesis. I. Response of immature hapten- specific B lymphocytes

B lymphocytes with receptors specific for the hapten fluorescein (FLU) were prepared from the spleens of mice of various ages. For most experiments, a one-step fractionation procedure based on the adherence of FLU-specific cells to FLU-gelatin was used. For some experiments, a subset of higher FLU-binding capacity was prepared from the FLU-gelatin binding population through the use of the fluorescence-activated cell sorter (FACS). FLU-specific B cells were placed into microculture with either FLU(3.6)-human gamma globulin (FLU(3.6)HGG) or FLU(12)HGG usually for 24 h at 37 degrees C. The tolerogen was then removed and 0.1 μg/ml of a T-independent antigen, FLU-polymerized flagellin, was substituted. 3 days later, cells were harvested from the microcultures and assayed for FLU-specific plaque-forming cells to determine any reduction in clonable hapten-specific B cells which the tolerogenesis treatment might have induced. The results showed that with FLU(3.6)HGG, hapten-specific newborn B cells could be tolerized at 1,000-fold lower tolerogen concentrations than adult splenic B cells of equal antigen-binding capacity. The high-avidity subset was even more susceptible to tolerance induction. Tolerance could be induced within 8 but not within 2 h, and at lower tolerogen concentrations, longer periods of tolerogenesis were required for a given effect. Using a 24-h tolerogenesis phase, 50 percent reduction in clone frequency among newborn FLU-gelatin fractionated cells was achieved at 0.08 μg/ml of FLU(3.6)HGG. Tolerance induction in immature B cells was inhibited by the concomitant presence of a polyclonal B-cell activator, Escherichia coli lipopolysaccharide (LPS) but tolerance once induced, was stable to challenge with LPS. Tolerogenesis was hapten specific. The proportion of tolerizable cells in spleens decreased with increasing age, reaching 50 percent at around 9 days. FLUI(12)HGG proved a more powerful tolerogen than FLU(3.6)HGG. It had an effect on adult cells, 50 percent reduction in clone frequency being noted at around 1 μg/ml. However, and in contrast to results claimed for other T- independent systems, there still was a major difference between immature and mature B cells, the immature cells displaying much greater sensitivity to tolerogenesis.
The Relationship of Upwelling to Mussel Production in the Rias on the Western Coast of Spain

We have calculated an upwelling index for each month over a 17-year period (1969-1985) for a point off the western coast of Spain. We interpret April through September values of the index to indicate the flux of nitrate-rich water into the Spanish Rias. The index representing the 6-month upwelling series has been correlated with an index representing the conditions of mussels grown during that season on rafts in Ria de Arosa. Two seasons represent extreme upwelling conditions over the 17-year sampling period: 1977 when the upwelling index was the highest, and 1983 when it was the lowest. A comparison of the condition of mussels during these years showed that meat content was double in 1977. We suggest, by this study, that long range forecasts of synoptic scale weather patterns could be used to predict the potential nutritional value of mussels harvested in the rias of Spain.