Miracle-dz/UniFAR-FTUs huggingface dataset:
Validating a conceptual model for an inter-professional approach to shared decision making: a mixed methods study

Rationale, aims and objectives Following increased interest in having inter-professional (IP) health care teams engage patients in decision making, we developed a conceptual model for an IP approach to shared decision making (SDM) in primary care. We assessed the validity of the model with stakeholders in Canada. Methods In 15 individual interviews and 7 group interviews with 79 stakeholders, we asked them to: (1) propose changes to the IP-SDM model; (2) identify barriers and facilitators to the model's implementation in clinical practice; and (3) assess the model using a theory appraisal questionnaire. We performed a thematic analysis of the transcripts and a descriptive analysis of the questionnaires. Results Stakeholders suggested placing the patient at its centre; extending the concept of family to include significant others; clarifying outcomes; highlighting the concept of time; merging the micro, meso and macro levels in one figure; and recognizing the influence of the environment and emotions. The most common barriers identified were time constraints, insufficient resources and an imbalance of power among health professionals. The most common facilitators were education and training in inter-professionalism and SDM, motivation to achieve an IP approach to SDM, and mutual knowledge and understanding of disciplinary roles. Most stakeholders considered that the concepts and relationships between the concepts were clear and rated the model as logical, testable, having clear schematic representation, and being relevant to inter-professional collaboration, SDM and primary care. Conclusions Stakeholders validated the new IP-SDM model for primary care settings and proposed few modifications. Future research should assess if the model helps implement SDM in IP clinical practice.
Parallel and Sequential Job Scheduling in Heterogeneous Clusters: A Simulation Study Using Software in the Loop

The task of designing and optimizing job scheduling algorithms for heterogeneous computing environments requires the ability to predict scheduling performance. The complexity of heterogeneous scheduling issues re quires that the experiments devised to test a scheduling paradigm to be both flexible and extensive. Experimen tally determined models for the prediction of job execu tion times on both sequential and parallel computing resources are combined with the implementation of a novel scheduling algorithm and a software-in-the-loop (SWIL) simulation. The result is a potent design and analysis approach for job scheduling algorithms and implementations intended for heterogeneous environ ments. This paper develops the concepts, mechanisms, and results of a SWIL design and analysis approach. The merits of this approach are shown in four case stud ies, which determine overhead, scheduling performance, and the impact of preemption and priority policies. These case studies illustrate the contributions of this research in the form of a new parallel job scheduling algorithm for heterogeneous computing and in the novel application of SWIL simulation to the analysis of job scheduling systems.
Toxicant-Induced Leakage of Germ Cell–Specific Proteins from Seminiferous Tubules in the Rat: Relationship to Blood-Testis Barrier Integrity and Prospects for Biomonitoring

Evaluation of testicular toxicity during drug development is currently based on histopathological evaluation. A sensitive biomarker for testicular toxicology could provide an in-life and “early warning” measurement. Previous studies suggested that disruption of spermatogenesis induced leakage of germ cell proteins from seminiferous tubules (STs) into interstitial fluid (IF); such proteins have potential for use as biomarkers. To investigate this possibility further, adult male rats were treated with three testicular toxicants thought to have differing sites of action; cadmium chloride affects the blood-testis barrier (BTB), methoxyacetic acid (MAA) disrupts pachytene spermatocytes, and 1,3-dinitrobenzene (DNB) targets Sertoli cells. IF proteins were assessed by Coomassie-based dye-stained gels. Immunostaining was used to identify toxicant-induced damage (DAZL) and BTB integrity (ZO-1, occludin, N-cadherin, and β-catenin) and function (biotin). Cadmium chloride induced dose-dependent leakage of proteins from STs into IF coincident with loss of integrity and function of the BTB. Two of the “leaked” proteins were identified on Westerns as being germ cell specific, namely VASA and fatty acid–binding protein 9 (FABP9). In contrast, similar protein leakage was not evident after either MAA-induced or DNB-induced disruption of spermatogenesis and neither of these treatments affected BTB integrity or function. These results suggest that loss of BTB integrity is required for germ cell–specific proteins to leak from STs into IF, implying that use of such biomarkers has very limited potential for noninvasive monitoring of compound-induced disruption to spermatogenesis.
Thermal and dynamic mechanical characterization of polypropylene‐woodflour composites

The performance of wood particle/polypropylene (PP) composites with modified compatibilities was compared. Woodflour modification was performed by esterification with maleic anhydride (MAN) and a non-commercial maleic anhydride-polypropylene copolymer (PPMAN) was selected as compatibilizing agent. The thermogravimetric analysis indicates that the onset of thermal degradation of treated woodflour occurs at lower temperature than that of the untreated one, and the same behavior was found in the corresponding composites. Differential scanning calorimetry indicated that both woodflours acted as nucleating agents for PP, while only treated woodflour induced PP crystallization in β-phase in the composites. X-ray diffractometry demonstrated that the crystallization in p-phase was a shear-induced phenomenon favored by the chemical modification of the woodflour surface. Dynamic mechanical studies suggested that composite properties decreased at concentrations higher than 40 wt% of woodflour and that the overall performance of MAN-treated woodflour composites was lower than that of the composites where a compatibilizing agent was added.
From Supermassive Black Holes to Dwarf Elliptical Nuclei: A Mass Continuum

Considerable evidence suggests that supermassive black holes reside at the centers of massive galactic bulges. At a lower galactic mass range, many dwarf galaxies contain extremely compact nuclei that structurally resemble massive globular clusters. We show that both these types of central massive objects (CMOs) define a single unbroken relation between CMO mass and the luminosity of their host galaxy spheroid. Equivalently, MCMO is directly proportional to the host spheroid mass over 4 orders of magnitude. We therefore suggest that the dE,N nuclei may be the low-mass analogs of supermassive black holes and that these two types of CMOs may have both developed starting from similar initial formation processes. The overlap mass interval between the two types of CMOs is small and suggests that for MCMO > 107 M☉, the formation of a black hole was strongly favored, perhaps because the initial gas infall to the center was too rapid and violent for star formation to occur efficiently.
Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors

ETV1 (ER81) is a transcription factor that can be activated by HER2/Neu, a proto‐oncoprotein often overexpressed in metastatic breast tumors. Here, we demonstrate that ETV1 downregulation suppresses proliferation of HER2/Neu‐positive MDA‐MB‐231 breast cancer cells in vitro and tumor formation in vivo, proving for the first time the existence of a critical role of ETV1 in breast cancer cell physiology. A screen for novel ETV1 target genes hinted at Rcl, an enzyme involved in nucleotide metabolism. To characterize the human Rcl gene, we cloned its promoter and found that ETV1 and HER2/Neu cooperated in activating the Rcl promoter, whereas a dominant‐negative ETV1 molecule suppressed the Rcl promoter. Moreover, ETV1 and HER2/Neu synergized to upregulate the endogenous Rcl gene. ETV1 also bound to the Rcl promoter in vivo, indicating that Rcl is a bona fide target gene of ETV1. Hybridization of Rcl cDNA to a breast cancer array revealed that Rcl is overexpressed in ∼40% of all breast tumors. Importantly, its expression significantly escalates with increasing tumor grade, strongly implicating that Rcl contributes to breast tumorigenesis. Since joint overexpression of Rcl with vascular endothelial growth factor, another target gene of ETV1, has been shown to induce tumor formation, Rcl may be one crucial effector of ETV1 and HER2/Neu in breast tumors. Furthermore, given its expression pattern and enzymatic function in nucleotide metabolism, Rcl presents itself as a novel target in breast cancer therapy via modulation of its activity by small molecule drugs. J. Cell. Biochem. 105: 866–874, 2008. © 2008 Wiley‐Liss, Inc.
A population-based study of the effectiveness of inferior vena cava filter use among patients with venous thromboembolism.

BACKGROUND There are few population-based data regarding the effectiveness of inferior vena cava filter use in the prevention of symptomatic pulmonary embolism. OBJECTIVE To determine the 1-year cumulative incidence of rehospitalization for venous thrombosis or pulmonary embolism among patients with thromboembolism treated with a vena cava filter compared with the incidence in a control population with thromboembolism. PATIENTS AND METHODS Population-based retrospective analysis of linked hospital discharge abstracts in California. From January 1, 1991, through December 30, 1995, 3632 patients were treated with a filter and 64,333 controls were admitted with a principal diagnosis of venous thromboembolism. RESULTS Filter-treated patients had significantly greater comorbidity, with a higher frequency of previous pulmonary embolism, recent major bleeding, malignant neoplasm, and stroke. Patients who initially manifested pulmonary embolism were significantly more likely to be rehospitalized for pulmonary embolism than patients with an initial diagnosis of venous thrombosis alone, among filter-treated patients (relative risk, 6.72; 95% confidence interval, 3.61-12.49) and controls (relative risk, 5.30; 95% confidence interval, 4.61-6.10). Risk-adjusted proportional hazards modeling showed no significant difference between filter-treated patients and controls in the relative hazard of rehospitalization for pulmonary embolism. However, filter placement was associated with a significantly higher relative hazard of rehospitalization for venous thrombosis among patients who initially manifested pulmonary embolism (relative hazard, 2.62; 95% confidence interval, 2.09-3.29), but not among those who presented with venous thrombosis (relative hazard, 1.14; 95% confidence interval, 0.92-1.43). CONCLUSIONS Insertion of a vena cava filter was not associated with a significant reduction in the 1-year incidence of rehospitalization for pulmonary embolism. Use of a filter was associated with a higher incidence of rehospitalization for venous thrombosis, but only among patients who initially manifested pulmonary embolism. A prospective clinical study is needed to determine the efficacy of filter use among patients with pulmonary embolism who do not meet strict guidelines for insertion of a vena cava filter.
Defining LFIs and LFUs in extensions of infectious logics

The aim of this paper is to explore the peculiar case of infectious logics, a group of systems obtained generalizing the semantic behavior characteristic of the -fragment of the logics of nonsense, such as the ones due to Bochvar and Halldén, among others. Here, we extend these logics with classical negations, and we furthermore show that some of these extended systems can be properly regarded as logics of formal inconsistency (LFIs) and logics of formal undeterminedness (LFUs).
Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability

Previous reports have shown that expression of BARD1δ, a deletion-bearing isoform of BARD1, correlates with tumor aggressiveness and progression. We show that expression of BARD1δ induces cell cycle arrest in vitro and in vivo in non-malignant cells. We investigated the mechanism that leads to proliferation arrest and found that BARD1δ overexpression induced mitotic arrest with chromosome and telomere aberrations in cell cultures, in transgenic mice, and in cells from human breast and ovarian cancer patients with BARD1 mutations. BARD1δ binds more efficiently than BARD1 to telomere binding proteins and causes their depletion from telomeres, leading to telomere and chromosomal instability. While this induces cell cycle arrest, cancer cells lacking G2/M checkpoint controls might continue to proliferate despite the BARD1δ-induced chromosomal instability. These features of BARD1δ may make it a genome permutator and a driver of continuous uncontrolled proliferation of cancer cells.
Enhancing Accountability and Trust in Distributed Ledgers

Permisionless decentralized ledgers ("blockchains") such as the one underlying the cryptocurrency Bitcoin allow anonymous participants to maintain the ledger, while avoiding control or "censorship" by any single entity. In contrast, permissioned decentralized ledgers exploit real-world trust and accountability, allowing only explicitly authorized parties to maintain the ledger. Permissioned ledgers support more flexible governance and a wider choice of consensus mechanisms. Both kinds of decentralized ledgers may be susceptible to manipulation by participants who favor some transactions over others. The real-world accountability underlying permissioned ledgers provides an opportunity to impose fairness constraints that can be enforced by penalizing violators after-the- fact. To date, however, this opportunity has not been fully exploited, unnecessarily leaving participants latitude to manipulate outcomes undetectably. This paper draws attention to this issue, and proposes design principles to make such manipulation more difficult, as well as specific mechanisms to make it easier to detect when violations occur.
Synergistic Effect of Colistin and Rifampin Against Multidrug Resistant Acinetobacter baumannii: A Systematic Review and Meta-Analysis

The existence of infections caused by multidrug resistant (MDR) Acinetobacter baumannii is a growing problem because of the difficulty to treat them. We examined the published literature and focused our analysis on the investigation of the synergism of colistin and rifampin against MDR A. baumannii isolates via systematic review and meta-analysis. A systematic literature search was performed using the following 4 databases (PubMed, Scopus, EMBASE and ISI Web of Sciences). The related articles were evaluated during the period from December 2014 to January 2015. Information based on resistance and sensitivity to antibiotics, the minimum inhibitory concentration and the effects of two antibiotics on each other including synergism, antagonism, relative synergism and additive antagonism were extracted. A meta-analysis of 17 studies including 448 samples was brought into process and 2% (95% CI 0-4%) and 72% (95% CI 56-89%) resistance to colistin and rifampin were observed, respectively. 42% of all isolates showed MIC = 4 µg/ml (95% CI 14-69%) to rifampin and 30% MIC= 2 µg/ml to colistin (95% CI 3.8-78%). MIC50 and MIC90 for both rifampin and colistin were 2 µg/ml and 4 µg/ml, respectively. 63% of the strains demonstrated synergy (95% CI 37-90%), 7% were highlighted as relative synergism (95% CI 0.0- 13%), 3% showed an additive effect (95% CI -0.0-7%) and 14% were indifferent (95% CI 6-23%). The antagonistic effect was not observed in this combination. Synergy rates of time-kill assay in rifampin and colistin combinations were generally higher than those of check bored microdilution and E-test method. The results demonstrated that the combination therapy could be more useful when compared to monotherapy and that this strategy might reduce the resistance rate to rifampin in MDR A. baumannii isolates.
Music improves verbal memory encoding while decreasing prefrontal cortex activity: an fNIRS study

Listening to music engages the whole brain, thus stimulating cognitive performance in a range of non-purely musical activities such as language and memory tasks. This article addresses an ongoing debate on the link between music and memory for words. While evidence on healthy and clinical populations suggests that music listening can improve verbal memory in a variety of situations, it is still unclear what specific memory process is affected and how. This study was designed to explore the hypothesis that music specifically benefits the encoding part of verbal memory tasks, by providing a richer context for encoding and therefore less demand on the dorsolateral prefrontal cortex (DLPFC). Twenty-two healthy young adults were subjected to functional near-infrared spectroscopy (fNIRS) imaging of their bilateral DLPFC while encoding words in the presence of either a music or a silent background. Behavioral data confirmed the facilitating effect of music background during encoding on subsequent item recognition. fNIRS results revealed significantly greater activation of the left hemisphere during encoding (in line with the HERA model of memory lateralization) and a sustained, bilateral decrease of activity in the DLPFC in the music condition compared to silence. These findings suggest that music modulates the role played by the DLPFC during verbal encoding, and open perspectives for applications to clinical populations with prefrontal impairments, such as elderly adults or Alzheimer’s patients.
SourcererCC and SourcererCC-I: Tools to Detect Clones in Batch Mode and during Software Development

Given the availability of large source-code repositories, there has been a large number of applications for large-scale clone detection. Unfortunately, despite a decade of active research, there is a marked lack in clone detectors that scale to big software systems or large repositories, specifically for detecting near-miss (Type 3) clones where significant editing activities may take place in the cloned code. This paper demonstrates: (i) SourcererCC, a token-based clone detector that targets the first three clone types, and exploits an index to achieve scalability to large inter-project repositories using a standard workstation. It uses an optimized inverted-index to quickly query the potential clones of a given code block. Filtering heuristics based on token ordering are used to significantly reduce the size of the index, the number of code-block comparisons needed to detect clones, as well as the number of required token-comparisons needed to judge a potential clone; and (ii) SourcererCC-I, an Eclipse plug-in, that uses SourcererCC's core engine to identify and navigate clones (both inter and intra project) in real-time during software development. In our experiments, comparing SourcererCC with the state-of-the-art tools we found that it is the only clone detection tool to successfully scale to 250 MLOC on a standard workstation with 12 GB RAM and efficiently detect the first three types of clones (precision 86% and recall 86-100%). Link to the demo: \url{https://youtu.be/l7F_9Qp-ks4}
Circulating Concentrations of Soluble Receptor for AGE Are Associated With Age and AGER Gene Polymorphisms in Children With Newly Diagnosed Type 1 Diabetes

OBJECTIVE We analyzed the relationship among soluble receptor for advanced glycation end products (sRAGEs), the clinical phenotype, HLA genotype, and risk-associated single nucleotide polymorphisms (SNPs) in the AGER gene in a large population of Finnish children with newly diagnosed type 1 diabetes. RESEARCH DESIGN AND METHODS Samples from 2,115 clinically phenotyped children <15 years of age in whom type 1 diabetes was diagnosed and 316 control subjects were analyzed for sRAGEs. Three SNPs of AGER, previously associated with HLA-DR/DQ haplotype independent diabetes risk (rs2070600, rs9469089, and rs17493811), were analyzed in 1,390 affected subjects. RESULTS Children with type 1 diabetes and control subjects had similar sRAGE concentrations (1,171 vs. 1,153 pg/mL, P = 0.48). There was a correlation between age at diagnosis and serum sRAGE concentrations (r = 0.10, P < 0.001) among the patients but not among the control subjects. Children <2 years of age had the lowest concentrations in the diabetic population (1,027 vs. 1,181 pg/mL, P < 0.001) and the highest among the control subjects (1,329 vs. 1,140 pg/mL, P = 0.04). Ketoacidosis at diagnosis was associated with reduced concentrations (1,086 vs. 1,190 pg/mL, P < 0.001). HLA DR3/DR4 heterozygosity and the DR3 allele were associated with reduced sRAGE concentrations. The predisposing AA genotype of rs2070600 was associated with decreased sRAGE concentrations, while the protective CC genotype of rs9469089 was linked to increased concentrations. CONCLUSIONS Age and AGER polymorphisms are associated with the circulating sRAGE concentration among children with type 1 diabetes. The observations of reduced sRAGE concentrations in young children, in those with ketoacidosis, and in carriers of the high-risk HLA DR3/DR4 genotype suggest that decreased sRAGE concentration reflects a more aggressive disease phenotype.
A unified impedance-based fault location method for generalized distribution systems

This paper proposes an extended and unified impedance-based fault location method which accounts for the inherent characteristics of distribution systems (unbalanced operation, presence of intermediate loads, laterals, and time-varying load profile). The technique is developed using phase-component analysis, and uses only local voltages and currents as input data. The time-varying load profile of distributions systems is considered by using an iterative procedure to update the load data used in the fault location algorithm. The procedure is based on matching both magnitude and angle of the prefault load impedance at the local terminal and the load impedance estimated through a power-flow analysis. In determining the equivalent power flow paths of branched distribution feeders a power-flow-based analysis is performed, enabling the technique to be applied in large distribution systems. Aiming to extend the application of the proposed method to underground in addition to overhead distribution systems, a set of generalized fault location equations which consider the shunt admittance of the lines was used. Test results show the accuracy and robustness of the fault location algorithm to different fault types, distances and resistances, considering system's load profile variations up to ± 50%.
Relationships between Ice Water Content and Volume Extinction Coefficient from In Situ Observations for Temperatures from 0° to −86°C: Implications for Spaceborne Lidar Retrievals

AbstractAn examination of 2 yr of Cloud–Aerosol Lidar Infrared Pathfinder Satellite Observations (CALIPSO) lidar observations and CloudSat cloud radar observations shows that ice clouds at temperatures below about −45°C frequently fall below the CloudSat radar’s detection threshold yet are readily detectable by the lidar. The CALIPSO ice water content (IWC) detection threshold is about 0.1 versus 5 mg m−3 for CloudSat. This comparison emphasizes the need for developing a lidar-only IWC retrieval method that is reliable for high-altitude ice clouds at these temperatures in this climatically important zone of the upper troposphere. Microphysical measurements from 10 aircraft field programs, spanning latitudes from the Arctic to the tropics and temperatures from −86° to 0°C, are used to develop relationships between the IWC and volume extinction coefficient σ in visible wavelengths. Relationships used to derive a radiatively important ice cloud property, the ice effective diameter De, from σ are also develop.