Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular characterization of classical and nonclassical MHC class I genes from the golden pheasant (Chrysolophus pictus)

Classical major histocompatibility complex (MHC) class I allelic polymorphism is essential for competent antigen presentation. To improve the genotyping efforts in the golden pheasant, it is necessary to differentiate more accurately between classical and nonclassical class I molecules. In our study, all MHC class I genes were isolated from one golden pheasant based on two overlapping PCR amplifications. In total, six full‐length class I nucleotide sequences (A–F) were identified, and four were novel. Two (A and C) belonged to the IA1 gene, two (B and D) were alleles derived from the IA2 gene through transgene amplification, and two (E and F) comprised a third novel locus, IA3 that was excluded from the core region of the golden pheasant MHC‐B. IA1 and IA2 exhibited the broad expression profiles characteristic of classical loci, while IA3 showed no expression in multiple tissues and was therefore defined as a nonclassical gene. Phylogenetic analysis indicated that the three IA genes in the golden pheasant share a much closer evolutionary relationship than the corresponding sequences in other galliform species. This observation was consistent with high sequence similarity among them, which likely arises from the homogenizing effect of recombination. Our careful distinction between the classical and nonclassical MHC class I genes in the golden pheasant lays the foundation for developing locus‐specific genotyping and establishing a good molecular marker system of classical MHC I loci.
Predicting Savings From Adolescence to Young Adulthood: A Propensity Score Approach

This paper examines the progression of savings between adolescence and young adulthood. Using data from the Panel Study of Income Dynamics, we ask whether the likelihood of having a savings account in young adulthood and the amount of savings can be significantly predicted by two factors: having a savings account during adolescence and having parents who own assets. Descriptive statistics reveal that adolescents with savings accounts are more often White, employed, and live in households in which the head is married, has more education, and owns assets. Propensity score analyses confirm that young adults are more likely to have a savings account when they have a savings account as adolescents. Some evidence suggests that adolescents whose parents have savings on their behalf and have higher net worth are more likely to have higher amounts of savings as young adults. Findings suggest that parents play an important role in modeling saving habits for adolescents. Further, our findings suggest that having a savings account in adolescence leads to an increased likelihood of having a savings account in young adulthood; however, this finding requires confirmation in future research.
Generalized Hénon Map and Bifurcations of Homoclinic Tangencies

We study two-parameter bifurcation diagrams of a generalized Henon map (GHM) that is known to describe dynamics of iterated maps near homoclinic and heteroclinic tangencies. We prove the nondegeneracy of codimension (codim) 2 bifurcations of fixed points of the GHM analytically and compute its various global and local bifurcation curves numerically. Special attention is given to the interpretation of the results and their application to the analysis of bifurcations of the homoclinic tangency of a neutral saddle in two-parameter families of planar diffeomorphisms. In particular, an infinite cascade of homoclinic tangencies of neutral saddle cycles is shown to exist near the homoclinic tangency of the primary neutral saddle.
Team-training in healthcare: a narrative synthesis of the literature

Background Patients are safer and receive higher quality care when providers work as a highly effective team. Investment in optimising healthcare teamwork has swelled in the last 10 years. Consequently, evidence regarding the effectiveness for these interventions has also grown rapidly. We provide an updated review concerning the current state of team-training science and practice in acute care settings. Methods A PubMed search for review articles examining team-training interventions in acute care settings published between 2000 and 2012 was conducted. Following identification of relevant reviews with searches terminating in 2008 and 2010, PubMed and PSNet were searched for additional primary studies published in 2011 and 2012. Primary outcomes included patient outcomes and quality indices. Secondary outcomes included teamwork behaviours, knowledge and attitudes. Results Both simulation and classroom-based team-training interventions can improve teamwork processes (eg, communication, coordination and cooperation), and implementation has been associated with improvements in patient safety outcomes. Thirteen studies published between 2011 and 2012 reported statistically significant changes in teamwork behaviours, processes or emergent states and 10 reported significant improvement in clinical care processes or patient outcomes, including mortality and morbidity. Effects were reported across a range of clinical contexts. Larger effect sizes were reported for bundled team-training interventions that included tools and organisational changes to support sustainment and transfer of teamwork competencies into daily practice. Conclusions Overall, moderate-to-high-quality evidence suggests team-training can positively impact healthcare team processes and patient outcomes. Additionally, toolkits are available to support intervention development and implementation. Evidence suggests bundled team-training interventions and implementation strategies that embed effective teamwork as a foundation for other improvement efforts may offer greatest impact on patient outcomes.
Integral micro-channel liquid cooling for power electronics

A novel integral micro-channel heat sink was developed, featuring an array of sub-millimeter channels fabricated directly in the back-metallization layer of the direct bond copper or active metal braze ceramic substrate, thus minimizing the material between the semiconductor junction and fluid and the overall junction-to-fluid thermal resistance. The ceramic substrate is bonded to a baseplate that includes a set of interleaved inlet and outlet manifolds for uniform fluid distribution across the actively cooled area of the heat sink. The interleaved manifolds greatly reduce the pressure drop and minimize temperature gradient across the heat sink surface. After performing detailed simulations and design optimization, a 200 A, 1200 V IGBT power module with the integral heat sink was fabricated and tested. The junction-to-fluid thermal resistivities for the IGBTs and diodes were 0.17°C⋆cm2/W and 0.14°C⋆cm2/W, respectively. The design is superior to all reported liquid cooled heat sinks with a comparable material system, including the micro-channel designs. It is also easily scaleable to larger heat sink surfaces without compromising the performance.
Lectin/glycan interactions play a role in recognition in a coral/dinoflagellate symbiosis

Recognition is an important stage in the establishment of highly specific mutualistic associations. Yet, for the majority of symbioses, very few of the mechanisms involved in recognition and specificity are known. In this study, we provide evidence for a recognition mechanism at the onset of symbiosis between larvae of the coral Fungia scutaria and their endosymbiotic dinoflagellate algae. This recognition step occurs during initial cellular contact between the symbiotic partners through a lectin/glycan interaction. We determined that an intact algal cell surface was required for successful infection of F. scutaria larvae. Modification of the algal cell surface by enzymatic digestion with trypsin or N‐glycosidase significantly reduced infection success, and implicated algal cell surface glycans in recognition. Using flow cytometry, α‐mannose/α‐glucose and α‐galactose residues were identified as potential recognition ligands on the algal cell surface. Finally, inhibition of these cell surface glycans significantly reduced infection of F. scutaria larvae by the algae. These data provide evidence that the algal cell surface contains glycan ligands, such as α‐mannose/α‐glucose and α‐galactose, which play a role in recognition during initial contact at the onset of symbiosis with F. scutaria larvae.
Identification of an Epstein‐Barr virus‐coded thymidine kinase.

We have demonstrated the presence of an Epstein‐Barr virus (EBV)‐coded thymidine kinase (TK) by producing biochemically transformed, TK‐positive mammalian cell lines using either microinjection of whole EBV virions or calcium phosphate‐mediated transfection of the SalI‐B restriction endonuclease fragment of EBV DNA. Analysis of these cell lines showed that: (i) EBV DNA was present in the cell lines, (ii) sequences from the SalI‐B restriction endonuclease fragment of EBV were expressed, (iii) a TK activity was present and (iv) a protein with antigenic cross‐reactivity with the herpes simplex virus (HSV) TK was produced. The identity of the EBV TK gene was determined by demonstrating that a recombinant plasmid, which expressed the protein product of the BXLF1 open reading frame as a fusion protein, could complement TK‐ strains of E. coli. A comparison of the predicted amino acid sequences of the TK proteins of EBV and HSV‐1 revealed significant regions of homology.
Intrinsic risk factors for exercise-related injuries among male and female army trainees

Physical training-related injuries are common among army recruits and other vigorously active populations, but little is known about their causation. To identify intrinsic risk factors, we prospectively measured 391 army trainees. For 8 weeks of basic training, 124 men and 186 women (79.3%) were studied. They answered questionnaires on past activities and sports participa tion, and were measured for height, weight, and body fat percentage; 71 % of the subjects took an initial army physical training test. Women had a significantly higher incidence of time-loss injuries than men, 44.6% com pared with 29.0%. During training, more time-loss in juries occurred among the 50% of the men who were slower on the mile run, 29.0% versus 0.0%. Slower women were likewise at greater risk than faster ones, 38.2% versus 18.5%. Men with histories of inactivity and with higher body mass index were at greater injury risk than other men, as were the shortest women. We conclude that female gender and low aerobic fitness measured by run times are risk factors for training injuries in army trainees, and that other factors such as prior activity levels and stature may affect men and women differently.
Population Bottlenecks as a Potential Major Shaping Force of Human Genome Architecture

The modern synthetic view of human evolution proposes that the fixation of novel mutations is driven by the balance among selective advantage, selective disadvantage, and genetic drift. When considering the global architecture of the human genome, the same model can be applied to understanding the rapid acquisition and proliferation of exogenous DNA. To explore the evolutionary forces that might have morphed human genome architecture, we investigated the origin, composition, and functional potential of numts (nuclear mitochondrial pseudogenes), partial copies of the mitochondrial genome found abundantly in chromosomal DNA. Our data indicate that these elements are unlikely to be advantageous, since they possess no gross positional, transcriptional, or translational features that might indicate beneficial functionality subsequent to integration. Using sequence analysis and fossil dating, we also show a probable burst of integration of numts in the primate lineage that centers on the prosimian–anthropoid split, mimics closely the temporal distribution of Alu and processed pseudogene acquisition, and coincides with the major climatic change at the Paleocene–Eocene boundary. We therefore propose a model according to which the gross architecture and repeat distribution of the human genome can be largely accounted for by a population bottleneck early in the anthropoid lineage and subsequent effectively neutral fixation of repetitive DNA, rather than positive selection or unusual insertion pressures.
Exploring space and place in marketing research

Based on an ethnographic study of American garages, we develop a model of the roles that liminal spaces perform in the management of possessions and their meanings. We find that the garage serves as a transitional space that links the useful and useless, female and male, clean and dirty, sacred and profane, and past, present, and future. We also propose that the garage can be a de facto museum and prosthetic memory device, as well as a link across generations of the family. Based on these findings, we offer a model of liminal household spaces and their dynamic role in making and managing meanings of everyday life.
Swimming Against the Flow: A Mechanism of Zooplankton Aggregation

Zooplankton reside in a constantly flowing environment. However, information about their response to ambient flow has remained elusive, because of the difficulties of following the individual motions of these minute, nearly transparent animals in the ocean. Using a three-dimensional acoustic imaging system, we tracked >375,000 zooplankters at two coastal sites in the Red Sea. Resolution of their motion from that of the water showed that the animals effectively maintained their depth by swimming against upwelling and downwelling currents moving at rates of up to tens of body lengths per second, causing their accumulation at frontal zones. This mechanism explains how oceanic fronts become major feeding grounds for predators and targets for fishermen.
Fully unsupervised word learning from continuous speech using transitional probabilities of atomic acoustic events

This work presents a learning algorithm based on transitional probabilities of atomic acoustic events (vector quantized spectral features). The algorithm learns models for word-like units in speech without any supervision, and without a priori knowledge of phonemic or linguistic units. The learned models can be used to segment novel utterances into word-like units, supporting the theory that transitional probabilities of acoustic events could work as a bootstrapping mechanism of language learning. The performance of the algorithm is evaluated using a corpus of Finnish infant-directed speech.
Comparison between x-ray tube-based and synchrotron radiation-based μCT

Nowadays, X-ray tube-based high-resolution CT systems are widely used in scientific research and industrial applications. But the potential, convenience and economy of these lab systems is often underestimated. The present paper shows the comparison of sophisticated conventional μCT with synchrotron radiation-based μCT (SRμCT). The different aspects and characteristics of both approaches like spatial and density resolution, penetration depth, scanning time or sample size is described in detail. The tube-based μCT measurements were performed with a granite-based nanotom®-CT system (phoenix|x-ray, Wunstorf, Germany) equipped with a 180 kV - 15 W high-power nanofocus® tube with tungsten or molybdenum targets. The tube offers a wide range of applications from scanning low absorbing samples in nanofocus® mode with voxel sizes below 500 nm and highly absorbing objects in the high power mode with focal spot and voxel sizes of a few microns. The SRμCT measurements were carried out with the absorption contrast set-up at the beamlines W 2 and BW 2 at HASYLAB/DESY, operated by the GKSS Research Center. The range of samples examined covers materials of very different absorption levels and related photon energies for the CT scans. Both quantitative and qualitative comparisons of CT scans using biomedical specimens with rather low X-ray absorption such as parts of the human spine as well as using composites from the field of materials science are shown.
Kenya's Agricultural Planning

THE TITLE OF MY TALK " Kenya's Agricultural Planning " is a bit misleading. I propose mainly to concentrate on one aspect of planning in the African areas but I will first give you a brief overall picture of agriculture in Kenya. I will talk for about twenty minutes and then put on some slides to give you a visual indication of what we are doing and what we are aiming at agriculturally. Kenya can be divided very broadly into four main areas. The area tucked down in the South-West quarter of this map is, agriculturally, virtually the whole of Kenya, about one-quarter to one-third of Kenya. Within the red line there, the area lies above an altitude of 4,000 feet and has a rainfall rising from 25 to 70 inches. The remainder of Kenya, about 150,000 square miles, is semi-arid pastoral land running 200 miles between the coast and the 4,000 foot contour, right up to the Northern Province and then across to Uganda. Rainfall is under 20 inches on the whole; in parts of the Northern Province under 10 inches. So there are our divisions. The main human population is concentrated down in the south-west quarter, the African Highlands; the main livestock population in the semi-arid pastoral areas, including the Kamba tribe and the Masai tribe down in the south. Then there are the coastal areas, the European Highlands and the big national forest reserves. I am not going to touch on European farming other than to say that a plan was drawn up for European settlement at the beginning of this century, and that that plan, which is still going on, has been most successful from the point of view of Kenya, providing its main economic strength at the present time. When the Uganda Line was put in there were to be 600 miles of unproductive railway line before it reached Uganda. To overcome this, the second Commissioner for East Africa, Sir Charles Eliot, and Lord Delamere, planned the settlement of what are now the European Highlands, and that planned settlement has gone on to this day. I think it can be said of the European settlement plan-" Born 1900, still going strong. " Before the war, and during it, all the African colonies were extremely short of staff and technical knowledge, due partly to the period of depression followed immediately by war, when staff could not be increased. Towards the end of the war a ten-year development plan, 1946 to 1955, was drawn up for Kenya which, on the agricultural side, covered two main aspects-research and land conservation. It could be summed up in these words : research, to
Effect of short‐term cognitive psychotherapy on recurrence of duodenal ulcer: a prospective randomized trial.

&NA; The aim of this prospective, randomized trial was to assess whether short‐term cognitive psychotherapy (10 sessions during 4 months) could reduce the 1‐year recurrence rate of duodenal ulcer. One group received psychotherapy; one group was a control group. One hundred patients, aged 17 to 64 years, with duodenal ulcer were selected from March 1989 to May 1991. The main outcome measure was relapse of duodenal ulcer, which was verified by endoscopy. When psychotherapy started after cessation of antiulcer medication, the relapse‐free time was significantly shorter in the therapy group than in the controls. When the protocol was modified so that psychotherapy and antiulcer medication were given concomitantly, there was no significant difference in recurrence rate between the groups at 1‐year follow‐up (84% in the therapy group and 92% in the control group). Symptoms of upper abdominal discomfort/pain, measured every second month, decreased significantly in the therapy group compared to the control group. Psychotherapy led to less neuroticism (Eysenck Personality Questionnaire) and less trait anxiety (Spielberger Trait Anxiety Scale) compared to controls at 4 months. At the 12‐month follow‐up, most of this gain was lost, but the psychotherapy group had lower scores on “concern about disapproval” on the Sociotropy‐Autonomy Scale than the control group. There is no beneficial effect of short‐term cognitive psychotherapy on the 1‐year recurrence rate of duodenal ulcer.
Potential for Assessing Dynamic Problem-Solving at the Beginning of Higher Education Studies

There is a growing demand for assessment instruments which can be used in higher education, which cover a broader area of competencies than the traditional tests for disciplinary knowledge and domain-specific skills, and which measure students' most important general cognitive capabilities. Around the age of the transition from secondary to tertiary education, such assessments may serve several functions, including selecting the best-prepared candidates for certain fields of study. Dynamic problem-solving (DPS) is a good candidate for such a role, as tasks that assess it involve knowledge acquisition and knowledge utilization as well. The purpose of this study is to validate an online DPS test and to explore its potential for assessing students' DPS skills at the beginning of their higher education studies. Participants in the study were first-year students at a major Hungarian university (n = 1468). They took five tests that measured knowledge from their previous studies: Hungarian language and literature, mathematics, history, science and English as a Foreign Language (EFL). A further, sixth test based on the MicroDYN approach, assessed students' DPS skills. A brief questionnaire explored learning strategies and collected data on students' background. The testing took place at the beginning of the first semester in three 2-h sessions. Problem-solving showed relatively strong correlations with mathematics (r = 0.492) and science (r = 0.401), and moderate correlations with EFL (r = 0.227), history (r = 0.192), and Hungarian (r = 0.125). Weak but still significant correlations were found with certain learning strategies, positive correlations with elaboration strategies, and a negative correlation with memorization strategies. Significant differences were observed between male and female students; men performed significantly better in DPS than women. Results indicated the dominant role of the first phase of solving dynamic problems, as knowledge acquisition correlated more strongly with any other variable than knowledge utilization.
BCG Vaccination Reduces Risk of Tuberculosis Infection in Vaccinated Badgers and Unvaccinated Badger Cubs

Wildlife is a global source of endemic and emerging infectious diseases. The control of tuberculosis (TB) in cattle in Britain and Ireland is hindered by persistent infection in wild badgers (Meles meles). Vaccination with Bacillus Calmette-Guérin (BCG) has been shown to reduce the severity and progression of experimentally induced TB in captive badgers. Analysis of data from a four-year clinical field study, conducted at the social group level, suggested a similar, direct protective effect of BCG in a wild badger population. Here we present new evidence from the same study identifying both a direct beneficial effect of vaccination in individual badgers and an indirect protective effect in unvaccinated cubs. We show that intramuscular injection of BCG reduced by 76% (Odds ratio = 0.24, 95% confidence interval (CI) 0.11–0.52) the risk of free-living vaccinated individuals testing positive to a diagnostic test combination to detect progressive infection. A more sensitive panel of tests for the detection of infection per se identified a reduction of 54% (Odds ratio = 0.46, 95% CI 0.26–0.88) in the risk of a positive result following vaccination. In addition, we show the risk of unvaccinated badger cubs, but not adults, testing positive to an even more sensitive panel of diagnostic tests decreased significantly as the proportion of vaccinated individuals in their social group increased (Odds ratio = 0.08, 95% CI 0.01–0.76; P = 0.03). When more than a third of their social group had been vaccinated, the risk to unvaccinated cubs was reduced by 79% (Odds ratio = 0.21, 95% CI 0.05–0.81; P = 0.02).