Miracle-dz/UniFAR-FTUs huggingface dataset:
New perspectives on the dynamics of the adoption triangle using biographical, literary and psychoanalytic sources

The difficulty of qualitative research in the area of adoption process is the starting point for this work. Forms of data gathering and analysis that will capture the emotionality of adoption participants are outlined. The aim was to extend our psychoanalytic understanding of the dynamics of the ‘searching’ phenomenon in the adoption triangle. A review of the psychoanalytic literature pertinent to adoption was compiled and the applicability of the core concepts explored. There was a clear fit between these tools and the task of understanding the multi-layered nature of adoption. A systematic thematic analysis of narrative accounts of the lived experience of four subjects at each of the three points of the triangle (12 in total), revealed a number of new themes. Many of them were not found in the existing literature in the same way. It was apparent that the majority of the themes were evident in all three positions of the adoption triangle. The most significant among these was evidence of a particular kind of ‘triangular psychology’. The adoption triangle members were consistently preoccupied at many levels with those occupying both the other two positions. This stands in some contrast to a tendency in the literature to assume that subjects are dyadically preoccupied with those occupying just one of the other positions. This research suggested that all were triadically relating within the triangle. The empirical work in this research suggests the manner in which these preoccupations persist through time in complex and fluid interactions with each another. The idea of ‘triangular psychology’ illuminates the phenomenon of the ‘search’ as a core existential predicament in the lives and minds of adoption participants. In addition, a systemic thematic review of two novels in which adoption is a major theme was undertaken. The analysis of the novels (one from the 19th century and one from the 21st century) had a remarkable concordance with the themes from the research interviews. The vast majority of the interview themes were also present in the work by the two novelists. The implications for therapeutic work are considered. A more three dimensional way of thinking about object relationships is required when psychotherapy is offered to adoption related individuals.
Association between Body Mass Index and Mortality for Colorectal Cancer Survivors: Overall and by Tumor Molecular Phenotype

Background: Microsatellite instability (MSI) and BRAF mutation status are associated with colorectal cancer survival, whereas the role of body mass index (BMI) is less clear. We evaluated the association between BMI and colorectal cancer survival, overall and by strata of MSI, BRAF mutation, sex, and other factors. Methods: This study included 5,615 men and women diagnosed with invasive colorectal cancer who were followed for mortality (maximum: 14.7 years; mean: 5.9 years). Prediagnosis BMI was derived from self-reported weight approximately one year before diagnosis and height. Tumor MSI and BRAF mutation status were available for 4,131 and 4,414 persons, respectively. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) were estimated from delayed-entry Cox proportional hazards models. Results: In multivariable models, high prediagnosis BMI was associated with higher risk of all-cause mortality in both sexes (per 5-kg/m2; HR, 1.10; 95% CI, 1.06–1.15), with similar associations stratified by sex (Pinteraction: 0.41), colon versus rectum (Pinteraction: 0.86), MSI status (Pinteraction: 0.84), and BRAF mutation status (Pinteraction: 0.28). In joint models, with MS-stable/MSI-low and normal BMI as the reference group, risk of death was higher for MS-stable/MSI-low and obese BMI (HR, 1.32; P value: 0.0002), not statistically significantly lower for MSI-high and normal BMI (HR, 0.86; P value: 0.29), and approximately the same for MSI-high and obese BMI (HR, 1.00; P value: 0.98). Conclusions: High prediagnosis BMI was associated with increased mortality; this association was consistent across participant subgroups, including strata of tumor molecular phenotype. Impact: High BMI may attenuate the survival benefit otherwise observed with MSI-high tumors. Cancer Epidemiol Biomarkers Prev; 24(8); 1229–38. ©2015 AACR.
Peptides Derived from a Phage Display Library Inhibit Adhesion and Protect the Host against Infection by Paracoccidioides brasiliensis and Paracoccidioides lutzii

Paracoccidioides brasiliensis and Paracoccidioides lutzii are dimorphic fungi and are the etiological agents of paracoccidioidomycosis (PCM). Adhesion is one of the most important steps in infections with Paracoccidioides and is responsible for the differences in the virulence of isolates of these fungi. Because of the importance of adhesion to the establishment of an infection, this study focused on the preliminary development of a new therapeutic strategy to inhibit adhesion by Paracoccidioides, thus inhibiting infection and preventing the disease. We used two phage display libraries to select peptides that strongly bind to the Paracoccidioides cell wall to inhibit adhesion to host cells and extracellular matrix (ECM) components (laminin, fibronectin, and type I and type IV collagen). This approach allowed us to identify four peptides that inhibited up to 64% of the adhesion of Paracoccidioides to pneumocytes in vitro and inhibited the adhesion to the ECM components by up to 57%. Encouraged by these results, we evaluated the ability of these peptides to protect Galleria mellonella from Paracoccidioides infection by treating G. mellonella larvae with the different peptides prior to infection with Paracoccidioides and observing larval survival. The results show that all of the peptides tested increased the survival of the larvae infected with P. brasiliensis by up to 64% and by up to 60% in those infected with P. lutzii. These data may open new horizons for therapeutic strategies to prevent PCM, and anti-adhesion therapy could be an important strategy.
Sea-blue histiocytes in familial lecithin: cholesterol acyltransferase deficiency.

Histiocytes containing large blue-green granules on Wright or Giemsa stain have been described in several different clinical conditions, some of them with hepatosplenomegaly and thrombocytopenia. These conditions have been ill-defined with no common characteristics. In the present report evidence is given for the presence of ‘sea-blue histiocytes’ in all five patients with familial lecithin: cholesterol acyltransferase deficiency examined. From electron microscopic studies it is suggested that the characteristic cytological appearance of the histiocytes in the spleen and bone marrow in these patients may be due to increased phagocytosis and decomposition of blood cells, or more probably to uptake of phospholipid-containing membraneous material directly from plasma.
Chemotaxis in Escherichia coli: A Molecular Model for Robust Precise Adaptation

The chemotaxis system in the bacterium Escherichia coli is remarkably sensitive to small relative changes in the concentrations of multiple chemical signals over a broad range of ambient concentrations. Interactions among receptors are crucial to this sensitivity as is precise adaptation, the return of chemoreceptor activity to prestimulus levels in a constant chemoeffector environment. Precise adaptation relies on methylation and demethylation of chemoreceptors by the enzymes CheR and CheB, respectively. Experiments indicate that when transiently bound to one receptor, these enzymes act on small assistance neighborhoods (AN) of five to seven receptor homodimers. In this paper, we model a strongly coupled complex of receptors including dynamic CheR and CheB acting on ANs. The model yields sensitive response and precise adaptation over several orders of magnitude of attractant concentrations and accounts for different responses to aspartate and serine. Within the model, we explore how the precision of adaptation is limited by small AN size as well as by CheR and CheB kinetics (including dwell times, saturation, and kinetic differences among modification sites) and how these kinetics contribute to noise in complex activity. The robustness of our dynamic model for precise adaptation is demonstrated by randomly varying biochemical parameters.
INVESTIGATING THE ROLE OF GOD ATTACHMENT, ADULT ATTACHMENT AND EMOTION REGULATION IN BINGE EATING

INVESTIGATING THE ROLE OF GOD ATTACHMENT, ADULT ATTACHMENT AND EMOTION REGULATION IN BINGE EATING Angela Charpia Weaver Center for Counseling and Family Studies Liberty University, Lynchburg, Virginia Doctor of Philosophy in Counseling Using a cross-sectional, self-report research design, this study examined a non-clinical population of 175 college women between the ages of 18-28 at a private, Christian university. A Pearson correlation matrix confirmed significant linear relationships between binge eating symptoms, emotion regulation, adult attachment insecurity and God attachment insecurity. A hierarchical multiple regression model determined that God attachment insecurity does not contribute unique variance toward binge eating symptoms after controlling for emotion regulation and adult attachment insecurity. Because God attachment insecurity was correlated to emotion regulation and adult attachment insecurity, and weakly correlated to binge eating symptoms without contributing unique variance, this study suggests that God attachment insecurity plays an indirect role in the perpetuation of binge eating symptoms.
Long-Term Nicotine Exposure Causes Increased Concentrations of Trypsinogens and Amylase in Pancreatic Extracts in the Rat

To develop radioimmunoassays (RIAs) for rat trypsinogens 1 and 2 and to investigate the effect of nicotine exposure on concentration and production of pancreatic zymogens in the rat. Methods: Male Sprague-Dawley rats were supplied with either normal or nicotine-containing (0.77 mM) water for 28 days and were then killed. Rabbit antibodies for the activation peptides of trypsinogens 1 and 2 were obtained for use in the RIAs. Concentrations of the both trypsinogens in pancreatic extracts were measured by the RIAs after activation by enterokinase. DNA and amylase were measured using commercial kits. mRNA for trypsinogens 1 and 2, procolipase, and cholecystokinin receptor was measured by in situ hybridization. Results: The specificity of the RIA for the trypsinogen 1 activation peptide was satisfactory. The RIA for the trypsinogen 2 activation peptide showed a limited cross-reaction toward the synthetic trypsinogen 1 activation peptide, but the importance of this cross-reaction was moderate when investigated in samples of activated trypsinogens. Weight gain was reduced in nicotine-treated animals. Concentrations of amylase, trypsinogen 1, trypsinogen 2, and the ratio of trypsinogen 2 to 1 were all increased in pancreatic extracts of nicotine-fed animals. Total DNA and mRNA for the trypsinogens, procolipase, and cholecystokinin receptor were not affected by nicotine exposure. Conclusions: The combination of increased proenzyme concentrations and unaffected mRNA levels suggests that nicotine impairs secretion rather than production of pancreatic zymogens.
An Effective Method of Pruning Support Vector Machine Classifiers

Support vector machine (SVM) classifiers often contain many SVs, which lead to high computational cost at runtime and potential overfitting. In this paper, a practical and effective method of pruning SVM classifiers is systematically developed. The kernel row vectors, with one-to-one correspondence to the SVs, are first organized into clusters. The pruning work is divided into two phases. In the first phase, orthogonal projections (OPs) are performed to find kernel row vectors that can be approximated by the others. In the second phase, the previously found vectors are removed, and crosswise propagations, which simply utilize the coefficients of OPs, are implemented within each cluster. The method circumvents the problem of explicitly discerning SVs in the high-dimensional feature space as the SVM formulation does, and does not involve local minima. With different parameters, 3000 experiments were run on the LibSVM software platform. After pruning 42% of the SVs, the average change in classification accuracy was only - 0.7%, and the average computation time for removing one SV was 0.006 of the training time. In some scenarios, over 90% of the SVs were pruned with less than 0.1% reduction in classification accuracy. The experiments demonstrate the existence of large numbers of superabundant SVs in trained SVMs, and suggest a synergistic use of training and pruning in practice. Many SVMs already used in applications could be upgraded by pruning nearly half of their SVs.
An investigation of broiler caecal Campylobacter counts at first and second thinning

The objectives of this study were the following: (i) to investigate if Campylobacter negative flocks at first thinning remain negative at second thinning; (ii) to determine if the caecal counts in birds infected during first thinning remain lower than in birds that were positive at first thinning; and (iii) to determine if reducing the time between first and second thinning to a maximum of 4 days would reduce both the incidence and prevalence of broiler caecal contamination.
Phylogeny and character evolution of the coprinoid mushroom genus Parasola as inferred from LSU and ITS nrDNA sequence data

Phylogenetic relationships, species concepts and morphological evolution of the coprinoid mushroom genus Parasola were studied. A combined dataset of nuclear ribosomal ITS and LSU sequences was used to infer phylogenetic relationships of Parasola species and several outgroup taxa. Clades recovered in the phylogenetic analyses corresponded well to morphologically discernable species, although in the case of P. leiocephala, P. lilatincta and P. plicatilis amended concepts proved necessary. Parasola galericuliformis and P. hemerobia are shown to be synonymous with P. leiocephala and P. plicatilis, respectively. By mapping morphological characters on the phylogeny, it is shown that the emergence of deliquescent Parasola taxa was accompanied by the development of pleurocystidia, brachybasidia and a plicate pileus. Spore shape and the position of the germ pore on the spores showed definite evolutionary trends within the group: from ellipsoid the former becomes more voluminous and heart-shaped, the latter evolves from central to eccentric in taxa referred to as ‘crown’ Parasola species. The results are discussed and compared to other Coprinus s.l. and Psathyrella taxa. Homoplasy and phylogenetic significance of various morphological characters, as well as indels in ITS and LSU sequences, are also evaluated.
Effect of subconjunctivally injected, liposome-bound, low-molecular-weight heparin on the absorption rate of subconjunctival hemorrhage in rabbits.

PURPOSE To investigate the effect of subconjunctival injection of liposome-bound, low-molecular-weight heparin (LMWH) on the absorption rate of subconjunctival hemorrhages. METHODS Subconjunctival hemorrhages were induced in both eyes of 30 rabbits by the subconjunctival injection of 0.1 mL of autologous blood from auricular marginal veins. After 8 hours, randomized subconjunctival injections of one of three materials were made: 5 IU/mL liposome-bound LMWH (0.1 mL) in 18 eyes (group A), only liposomes (0.1 mL) in 14 eyes (group B), the free form of LMWH (5 IU/mL, 0.1 mL) in 14 eyes (group C), or no injection in 14 eyes (group D). Subconjunctival hemorrhages were photographed with a digital camera at 8, 24, 48, 72, 96, and 120 hours after induction of subconjunctival hemorrhages, sized with an image analyzer, and compared between groups. RESULTS Subconjunctival hemorrhages were absorbed faster in group A (liposome-bound LMWH injected) than in with group B (liposome injected). Comparison of groups A and C (free LMWH injected) showed statistical differences in the absorption rates at 96 and 120 hours except at 24, 48, and 72 hours. The mean elapsed time for the complete resorption of subconjunctival hemorrhages was shortest in group A among four groups, whereas group B and the control showed no significant differences. The ocular and systemic absorption of LMWH were significantly lower after injection of the liposome-bound than the free form. CONCLUSIONS The subconjunctival injection of liposome-bound LMWH appears to enhance subconjunctival hemorrhage absorption in rabbits.
Combined Administration of Melissa officinalis and Boswellia serrata Extracts in an Animal Model of Memory

Background Boswellia serrata and Melissa officinalis is traditionally used for its memory enhancing effects. Objectives In this study, we evaluated the protective effects of combined form of these extracts on memory improvement of scopolamine treated rats by the Morris water maze method. Materials and Methods Two groups (group 1 and 2) of animals were pretreated with combined extracts of B. serrata and M. officinalis (200, 400 mg/Kg body weight) for four weeks and then, 30 minutes before starting the experiment scopolamine was injected (0.1 mg/kg body weight) intraperitoneally to pretreated animals. The control group was the animals that were injected by scopolamine and pre treated with distilled water (group 3). The normal group was treated with distilled water alone (group 4). Results For time spent and distance, there was no substantial difference between groups 1, 2 and 4, while they had statistical difference with group 3 (P = 0.001). The spatial memory evaluation showed no significant difference between treated groups and normal group. Conclusions Therefore, the combination of the two extracts had the ability to improve memory as its traditional use.
SMOS radiometric performance evaluation using SEPS: evaluation of thermal drifts

The SMOS (Soil Moisture and Ocean Salinity) Mission was selected in May 1999 by the European Space Agency to provide global and frequent soil moisture and sea surface salinity maps. SMOS single payload is MIRAS (Microwave Imaging Radiometer by Aperture Synthesis), an L-band 2D aperture synthesis interferometric radiometer with multi-angular observation capabilities and dual-polarization and full-polarimetric capabilities. The impact of thermal drifts in the SMOS rms radiometric accuracy during a complete orbit is evaluated by means of the SMOS End-to-end Performance Simulator (SEPS) [1,2,3] for three different cases of interest: the so-called "cold", "hot", and "LAP" (Low Available Power) cases, that correspond to the extreme thermal conditions in a year, and the case where there is not enough power to keep the thermal control. Errors originated by receivers' frequency response mismatch, and their thermal drifts are included, while antenna voltage patterns errors are assumed to be the same, and not temperature-dependent. Current error correction and image reconstruction algorithms are applied to obtain the synthetic brightness temperatures. To avoid scene-dependent effects on the rms radiometric accuracy drifts, it is computed using a 150 K constant brightness temperature in the directions occupied by the Earth, and external sources such as the Sun, the Moon and the sky (cosmic and galactic) radiations are not modeled by switching them off in SEPS. The inter-calibration period is estimated according to the maximum error drift that can be accepted in the different cases
International Outsourcing, Trade, Technology and Job Loss Fears: An Empirical Analysis with Micro-Level Data

The paper is concerned with the role of international outsourcing and import penetration for determining individual perceived job security. Combining industry-level outsourcing and trade measures with micro-level data from a large household panel survey, we estimate a number of conditional logit models accounting for the ordinal nature of reported job loss fears and individual unobserved heterogeneity. International outsourcing and import penetration on the whole are only found to yield insigniflcant results. However, more speciflcally deflned outsourcing to low-wage countries signiflcantly lowers perceived job security while outsourcing to high-wage countries signiflcantly raises perceived job security.
Apathy and Anhedonia in Parkinson's Disease

Depression, apathy, and anhedonia are often comorbid in patients with Parkinson's disease. Since the morbid states of apathy and anhedonia are complicated, these symptoms are often difficult to diagnose. Several therapeutic methods for apathy and anhedonia are considered effective. However, the validity of these methods has not been established. Similar to depression, apathy and anhedonia clearly affect the quality of life of patients and their families. Therefore, accurate diagnoses of morbid states in the early stage of the disease and corresponding appropriate treatments should be given high priority.
HMGB1 Promotes Systemic Lupus Erythematosus by Enhancing Macrophage Inflammatory Response

Background/Purpose. HMGB1, which may act as a proinflammatory mediator, has been proposed to contribute to the pathogenesis of multiple chronic inflammatory and autoimmune diseases including systemic lupus erythematosus (SLE); however, the precise mechanism of HMGB1 in the pathogenic process of SLE remains obscure. Method. The expression of HMGB1 was measured by ELISA and western blot. The ELISA was also applied to detect proinflammatory cytokines levels. Furthermore, nephritic pathology was evaluated by H&E staining of renal tissues. Results. In this study, we found that HMGB1 levels were significantly increased and correlated with SLE disease activity in both clinical patients and murine model. Furthermore, gain- and loss-of-function analysis showed that HMGB1 exacerbated the severity of SLE. Of note, the HMGB1 levels were found to be associated with the levels of proinflammatory cytokines such as TNF-α and IL-6 in SLE patients. Further study demonstrated that increased HMGB1 expression deteriorated the severity of SLE via enhancing macrophage inflammatory response. Moreover, we found that receptor of advanced glycation end products played a critical role in HMGB1-mediated macrophage inflammatory response. Conclusion. These findings suggested that HMGB1 might be a risk factor for SLE, and manipulation of HMGB1 signaling might provide a therapeutic strategy for SLE.