Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of the Prostaglandin E2 EP1 Receptor in Traumatic Brain Injury

Brain injuries promote upregulation of so-called proinflammatory prostaglandins, notably prostaglandin E2 (PGE2), leading to overactivation of a class of its cognate G-protein-coupled receptors, including EP1, which is considered a promising target for treatment of ischemic stroke. However, the role of the EP1 receptor is complex and depends on the type of brain injury. This study is focused on the investigation of the role of the EP1 receptor in a controlled cortical impact (CCI) model, a preclinical model of traumatic brain injury (TBI). The therapeutic effects of post-treatments with a widely studied EP1 receptor antagonist, SC-51089, were examined in wildtype and EP1 receptor knockout C57BL/6 mice. Neurological deficit scores (NDS) were assessed 24 and 48 h following CCI or sham surgery, and brain immunohistochemical pathology was assessed 48 h after surgery. In wildtype mice, CCI resulted in an obvious cortical lesion and localized hippocampal edema with an associated significant increase in NDS compared to sham-operated animals. Post-treatments with the selective EP1 receptor antagonist SC-51089 or genetic knockout of EP1 receptor had no significant effects on cortical lesions and hippocampal swelling or on the NDS 24 and 48 h after CCI. Immunohistochemistry studies revealed CCI-induced gliosis and microglial activation in selected ipsilateral brain regions that were not affected by SC-51089 or in the EP1 receptor-deleted mice. This study provides further clarification on the respective contribution of the EP1 receptor in TBI and suggests that, under this experimental paradigm, the EP1 receptor would have limited effects in modulating acute neurological and anatomical pathologies following contusive brain trauma. Findings from this protocol, in combination with previous studies demonstrating differential roles of EP1 receptor in ischemic, neurotoxic, and hemorrhagic conditions, provide scientific background and further clarification of potential therapeutic application of prospective prostaglandin G-protein-coupled receptor drugs in the clinic for treatment of TBI and other acute brain injuries.
Endothelial cell decay after descemet's stripping automated endothelial keratoplasty and top hat penetrating keratoplasty.

PURPOSE To analyze endothelial cell density (ECD) decay after Descemet's stripping automated endothelial keratoplasty (DSAEK) and top hat keratoplasty (THPK) in patients with Fuchs' endothelial dystrophy (FED) and/or pseudophakic bullous keratopathy (PPBK). METHODS Patients underwent either THPK (n = 33) or DSAEK (n = 39) at the Erasmus Medical Center, Rotterdam. For each nonrandomized cohort, a biexponential regression model for ECD decay was fitted. Factors associated with higher ECD decay were evaluated. RESULTS Median follow-up was 31.2 months (range, 11-91) in the THPK cohort, and 23.4 months (range, 6-61) in the DSAEK group. The early ECD decay was much higher after DSAEK (half time, 2.2 months) than after THPK (half time, 12.8 months). The late ECD decay after DSAEK was less steep (half time, 75.5 months) than after THPK (half time, 62 months). The 1-, 3- and 5-year endothelial cell losses derived from the models after DSAEK were 56%, 66%, and 73%, respectively, and after THPK were 24%, 50%, and 64%, respectively. For the DSAEK cohort, PPBK as an indication for surgery was associated with significantly higher late-phase decay rates. For the top-hat cohort, a significantly lower late-phase decay rate was found in PPBK. FED and same-session cataract surgery were confounding variables in the DSAEK cohort. Regarding DSAEK, postoperative re-bubbling was not found to have significant effects on early or late ECD decay rates. However, the small sample size and other limitations related to the method of evaluation may have influenced these findings. CONCLUSIONS After DSAEK, early ECD decay was stronger than after THPK, as opposed to late decay. Late decay was faster for PPBK than for FED after DSAEK.
Face recognition under generic illumination based on harmonic relighting

The performances of the current face recognition systems suffer heavily from the variations in lighting. To deal with this problem, this paper presents an illumination normalization approach by relighting face images to a canonical illumination based on the harmonic images model. Benefiting from the observations that human faces share similar shape, and the albedos of the face surfaces are quasi-constant, we first estimate the nine low-frequency components of the illumination from the input facial image. The facial image is then normalized to the canonical illumination by re-rendering it using the illumination ratio image technique. For the purpose of face recognition, two kinds of canonical illuminations, the uniform illumination and a frontal flash with the ambient lights, are considered, among which the former encodes merely the texture information, while the latter encodes both the texture and shading information. Our experiments on the CMU-PIE face database and the Yale B face database have shown that the proposed relighting normalization can significantly improve the performance of a face recognition system when the probes are collected under varying lighting conditions.
Depression has a Strong Relationship to Alterations in the Immune, Endocrine and Neural System

Epidemiological findings indicate a connection between depressive symptoms and changes in status of the immune system in depressed patients. This raises the possibility of causative connections. Theories on mechanisms for interactions between immune and affective systems – directly and via endocrine system – are evolving. Such hypothesized causative connections are supported by several findings. First, in depressed patients changes in the status of the immune system in vivo and ex vivo are seen. Also, depressive symptoms are seen in patients with altered immune status (physiologically, pathologically or chemically induced). Knowledge in this field may have implications regarding psychiatric follow up of physically ill people suffering from diseases caused by an altered immune system (long lasting infections, autoimmune diseases, hypersensitivity disorders) as well as disorders for which treatment and prognoses depends on the immune system (infections, cancer). Similarly, medical treatment of depressed patients may be adjusted by more specific knowledge about the interaction between neuroimmunology and depression. Important findings and the present knowledge and theories are reviewed.
Economic restructuring in Latin America in the face of the foreign debt and the external transfer problem

Presenta la idea de que los elementos claves para una reestructuracion socioeconomica de America Latina compatible con el servicio de la deuda son dos: i) los paises deudores deben seguir procurando lograr economias mas eficientes, con mayor competitividad internacional y mas capaces de generar exportaciones y de sustituir importaciones; y ii) el clima externo debe prestar apoyo e incentivos a tales esfuerzos como un financiamiento adecuado, menores tasas internacionales de interes real y mayor impulso a la exportacion de los paises latinoamericanos, por la via de mayor crecimiento de la produccion y del comercio internacional de los paises industrializados.
Seismic imaging of the Cocos plate subduction zone system in central Mexico

Broadband data from the Meso‐America Subduction Experiment (MASE) line in central Mexico were used to image the subducted Cocos plate and the overriding continental lithosphere beneath central Mexico using a generalized radon transform based migration. Our images provide insight into the process of subducting relatively young oceanic lithosphere and its complex geometry beneath continental North America. The converted and reverberated phase image shows complete horizontal tectonic underplating of the Cocos oceanic lithosphere beneath the North American continental lithosphere, with a clear image of a very thin low‐velocity oceanic crust (7–8 km) which dips at 15–20 degrees at Acapulco then flattens approximately 300 km from the Middle America Trench. Farther inland the slab then appears to abruptly change from nearly horizontal to a steeply dipping geometry of approximately 75 degrees underneath the Trans‐Mexican Volcanic Belt (TMVB). Where the slab bends underneath the TMVB, the migrated image depicts the transition from subducted oceanic Moho to continental Moho at ∼230 km from the coast, neither of which were clearly resolved in previous seismic images. The deeper seismic structure beneath the TMVB shows a prominent negative discontinuity (fast‐to‐slow) at ∼65–75 km within the upper mantle. This feature, which spans horizontally beneath the arc (∼100 km), may delineate the top of a layer of ponded partial melt.
On compositions of d.c. functions and mappings

A d.c. (delta-convex) function on a normed linear space is a function representable as a difference of two continuous convex functions. We show that an infinite dimensional analogue of Hartman's theorem on stability of d.c. functions under compositions does not hold in general. However, we prove that it holds in some interesting particular cases. Our main results about compositions are proved in the more general context of d.c. mappings between normed linear spaces.
HIV drug resistance analysis tool based on process algebra

The increasing number of drugs used in HIV patient treatment and the mutations associated with drug resistance make the inference of drug resistance a complex task that demands computational systems. Furthermore, the software development/update can generate an extra level of complexity in the process drug resistance analysis. An alternative to handle the complexity of drug resistance and software development is to use a formal representation of involved processes, such as process algebra. This allows mathematical reasoning about the analysis process, a precise description of system behavior, more advanced computational approaches, as concurrent/parallel execution and (semi) automatic software development. The first contribution of this research is a mapping of drug resistance algorithms rules into expressions of process algebra which facilitates the computational manipulation of theses rules. The second contribution is the HIVdag (HIV Drug Analysis Generator) system. This software supports the definition, generation and analyses of genotypic drug resistance tests based on process algebra expressions. Therefore, the users can easily create/update their own drug resistance algorithms any time and independent of software development.
Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF-β

Purpose: In glioma—in contrast to various other cancers—the impact of T-lymphocytes on clinical outcome is not clear. We investigated the clinical relevance and regulation of T-cell infiltration in glioma. Experimental Design: T-cell subpopulations from entire sections of 93 WHO°II–IV gliomas were computationally identified using markers CD3, CD8, and Foxp3; survival analysis was then done on primary glioblastomas (pGBM). Endothelial cells expressing cellular adhesion molecules (CAM) were similarly computationally quantified from the same glioma tissues. Influence of prominent cytokines (as measured by ELISA from 53 WHO°II–IV glioma lysates) on CAM-expression in GBM-isolated endothelial cells was determined using flow cytometry. The functional relevance of the cytokine-mediated CAM regulation was tested in a transmigration assay using GBM-derived endothelial cells and autologous T-cells. Results: Infiltration of all T-cell subsets increased in high-grade tumors. Most strikingly, within pGBM, elevated numbers of intratumoral effector T cells (Teff, cytotoxic and helper) significantly correlated with a better survival; regulatory T cells were infrequently present and not associated with GBM patient outcome. Interestingly, increased infiltration of Teff cells was related to the expression of ICAM-1 on the vessel surface. Transmigration of autologous T cells in vitro was markedly reduced in the presence of CAM-blocking antibodies. We found that TGF-β molecules impeded transmigration and downregulated CAM-expression on GBM-isolated endothelial cells; blocking TGF-β receptor signaling increased transmigration. Conclusions: This study provides comprehensive and novel insights into occurrence and regulation of T-cell infiltration in glioma. Specifically, targeting TGF-β1 and TGF-β2 might improve intratumoral T-cell infiltration and thus enhance effectiveness of immunotherapeutic approaches. Clin Cancer Res; 17(13); 4296–308. ©2011 AACR.
Recovery of Powerful Kick Biomechanics After Intense Running Fatigue in Male and Female Soccer Players

Background: Fatigue seems to have a significant effect on soccer kick performance. However, the duration of these effects has not been previously investigated. Objectives: The purpose of the present study was to investigate the duration of the acute effects of fatigue on soccer kick performance in males and females. Patients and Methods: Ten male (age: 26.3 ± 4.9 years, height: 178.1 ± 5.1 cm, mass: 81.3 ± 8.1 kg) and ten female (age: 24.4 ± 4.2 years, height: 169.7 ± 5.7 cm, mass: 61.8 ± 5.1 kg) amateur soccer players performed three instep kicks prior to and after running on a treadmill till exhaustion. Three-dimensional kinematics were collected pre- and post-fatigue. Results: Analysis of variance indicated a statistically significant decline in ball speed during the first and the second trial after fatigue (P < 0.05), but recovered to pre-fatigue levels during the third post-fatigue kicking trial (P > 0.05). Similarly, maximum ankle, knee and hip linear velocity and ankle angular displacement were significantly lower during the first two trials (P < 0.05), but not during the third trial after fatigue (P > 0.05). Conclusions: Soccer kick parameters recovered to pre-fatigue levels approximately within a minute after the end of the protocol. These findings have a practical meaning for players who have to perform set piece kicks under fatigue conditions and for coaches who have to guide their players.
Comparison Between Ultrasound-Guided Supraclavicular and Interscalene Brachial Plexus Blocks in Patients Undergoing Arthroscopic Shoulder Surgery

AbstractAlthough supraclavicular brachial plexus block (SCBPB) was repopularized by the introduction of ultrasound, its usefulness in shoulder surgery has not been widely reported. The objective of this study was to compare motor and sensory blockades, the incidence of side effects, and intraoperative opioid analgesic requirements between SCBPB and interscalene brachial plexus block (ISBPB) in patients undergoing arthroscopic shoulder surgery.Patients were randomly assigned to 1 of 2 groups (ISBPB group: n = 47; SCBPB group: n = 46). The side effects of the brachial plexus block (Horner's syndrome, hoarseness, and subjective dyspnea), the sensory block score (graded from 0 [no cold sensation] to 100 [intact sensation] using an alcohol swab) for each of the 5 dermatomes (C5–C8 and T1), and the motor block score (graded from 0 [complete paralysis] to 6 [normal muscle force]) for muscle forces corresponding to the radial, ulnar, median, and musculocutaneous nerves were evaluated 20 min after the brachial plexus block. Fentanyl was administered in 50 &mgr;g increments when the patients complained of pain that was not relieved by the brachial plexus block.There were no conversions to general anesthesia due to a failed brachial plexus block. The sensory block scores for the C5 to C8 dermatomes were significantly lower in the ISBPB group. However, the percentage of patients who received fentanyl was comparable between the 2 groups (27.7% [ISBPB group] and 30.4% [SCBPB group], P = 0.77). SCBPB produced significantly lower motor block scores for the radial, ulnar, and median nerves than did ISBPB. A significantly higher incidence of Horner's syndrome was observed in the ISBPB group (59.6% [ISBPB group] and 19.6% [SCBPB group], P < 0.001). No patient complained of subjective dyspnea.Despite the weaker degree of sensory blockade provided by SCBPB in comparison to ISBPB, opioid analgesic requirements are similar during arthroscopic shoulder surgery under both brachial plexus blocks. However, SCBPB produces a better motor blockade and a lower incidence of Horner's syndrome than ISBPB.
Exchange-Rate-Based Stabilization, Durables Consumption, and the Stylized Facts

In this paper we show that a model featuring durables consumption, weak credibility, and sticky prices can explain many of the stylized facts associated with exchange-rate-based stabilization, including the quantitative variation exhibited by key macroeconomic variables. In standard models, the boom phase of ERBS is nothing more than a tepid expansion – changes in spending, real output, and the real exchange rate are unexceptional. But when durables are part of the choice set, the boom is truly a boom: following a temporary reduction in the crawl, total consumption spending rises 12-20%, the real exchange rate appreciates 40-55%, and the current account deficit swells to 5-7% of GDP. None of these results requires easy intertemporal substitution in consumption.
Interaction of High Flash Point Electrolytes and PE-Based Separators for Li-Ion Batteries

In this study, promising electrolytes for use in Li-ion batteries are studied in terms of interacting and wetting polyethylene (PE) and particle-coated PE separators. The electrolytes are characterized according to their physicochemical properties, where the flow characteristics and the surface tension are of particular interest for electrolyte–separator interactions. The viscosity of the electrolytes is determined to be in a range of η = 4–400 mPa∙s and surface tension is finely graduated in a range of γL = 23.3–38.1 mN∙m−1. It is verified that the technique of drop shape analysis can only be used in a limited matter to prove the interaction, uptake and penetration of electrolytes by separators. Cell testing of Li|NMC half cells reveals that those cell results cannot be inevitably deduced from physicochemical electrolyte properties as well as contact angle analysis. On the other hand, techniques are more suitable which detect liquid penetration into the interior of the separator. It is expected that the results can help fundamental researchers as well as users of novel electrolytes in current-day Li-ion battery technologies for developing and using novel material combinations.
A Comparison of Atmospheric Reanalysis Products for the Arctic Ocean and Implications for Uncertainties in Air–Sea Fluxes

AbstractThe uncertainties related to atmospheric fields in the Arctic Ocean from commonly used and recently available reanalysis products are investigated. Fields from the 1) ECMWF Interim Re-Analysis (ERA-Interim), 2) Common Ocean–Ice Reference Experiment version 2 (CORE2), 3) Japanese 25-yr Reanalysis Project (JRA-25), 4) NCEP–NCAR reanalysis, 5) NCEP Climate Forecast System Reanalysis (CFSR), and 6) Modern-Era Retrospective Analysis for Research and Applications (MERRA) are evaluated against satellite-derived and in situ observations for zonal and meridional winds, precipitation, specific humidity, surface air temperature, and downwelling longwave and shortwave radiation fluxes. Comparison to reference observations shows that for variables such as air temperature and humidity, all reanalysis products have similar solutions. However, other variables such as winds, precipitation, and radiation show large spreads. The magnitude of uncertainties in all fields is large when compared to the signal. Biases in.
OPEN States in the Global Economy: The Political Economy of Small-State Macroeconomic Management

List of Figures List of Tables Preface Acronyms Translations Introduction PART I: CONCEPTUAL FRAMEWORK An Outside-In Framework Postwar International Regimes PART II: POSTWAR POLICY REGIMES Direct Planning in Norway: 1948-58 Indirect Steering: 1958-71 Flexible Adjustment: 1971-86 Price Flexibility: 1986-98 Conclusion Bibliography Index
Influence of Specimen Preparation and Test Methods on the Flexural Strength Results of Monolithic Zirconia Materials

The aim of this work was to evaluate the influence of specimen preparation and test method on the flexural strength results of monolithic zirconia. Different monolithic zirconia materials (Ceramill Zolid (Amann Girrbach, Koblach, Austria), Zenostar ZrTranslucent (Wieland Dental, Pforzheim, Germany), and DD Bio zx2 (Dental Direkt, Spenge, Germany)) were tested with three different methods: 3-point, 4-point, and biaxial flexural strength. Additionally, different specimen preparation methods were applied: either dry polishing before sintering or wet polishing after sintering. Each subgroup included 40 specimens. The surface roughness was assessed using scanning electron microscopy (SEM) and a profilometer whereas monoclinic phase transformation was investigated with X-ray diffraction. The data were analyzed using a three-way Analysis of Variance (ANOVA) with respect to the three factors: zirconia, specimen preparation, and test method. One-way ANOVA was conducted for the test method and zirconia factors within the combination of two other factors. A 2-parameter Weibull distribution assumption was applied to analyze the reliability under different testing conditions. In general, values measured using the 4-point test method presented the lowest flexural strength values. The flexural strength findings can be grouped in the following order: 4-point < 3-point < biaxial. Specimens prepared after sintering showed significantly higher flexural strength values than prepared before sintering. The Weibull moduli ranged from 5.1 to 16.5. Specimens polished before sintering showed higher surface roughness values than specimens polished after sintering. In contrast, no strong impact of the polishing procedures on the monoclinic surface layer was observed. No impact of zirconia material on flexural strength was found. The test method and the preparation method significantly influenced the flexural strength values.
Apparently changing patterns of inheritance in Alport's hereditary nephritis: Genetic heterogeneity versus altered diagnostic criteria

With the use of more stringent diagnostic criteria, it has recently been shown that some large pedigrees of Alport's and non‐Alport's hereditary nephritis fit sex‐linked dominant inheritance (O'Neill et al. 1978). We have used similar diagnostic criteria and have studied a number of Michigan pedigrees in order to see if this hypothesis would be confirmed. We found one small pedigree which definitely shows male‐to‐male transmission, while one large pedigree is tentatively compatible with sex‐linked dominant inheritance. Many of the other pedigrees suggested male‐to‐male transmission. This Michigan experience is compared to other published reports and found to be consistent, although a trend of fewer reports of male‐to‐male transmission is seen. We conclude that genetic heterogeneity of Alport's hereditary nephritis is likely.