Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Experimentally Induced Pain on Mismatch Negativity

Abstract: Previous research has found that pain can exert a disruptive effect on cognitive processing. This experiment was conducted to extend previous research with participants with chronic pain. This report examines pain's effects on early processing of auditory stimulus differences using the Mismatch Negativity (MMN) in healthy participants while they experienced experimentally induced pain. Event-related potentials (ERPs) were recorded using target and standard tones whose pitch differences were easy- or difficult-to-detect in conditions where participants attended to (active attention) or ignored (passive attention) the stimuli. Both attention manipulations were conducted in no pain and pain conditions. Experimentally induced ischemic pain did not disrupt the MMN. However, MMN amplitudes were larger to difficult-to-detect deviant tones during painful stimulation when they were attended than when they were ignored. Also, MMN amplitudes were larger to the difficult- than to the easy-to-detect tones in.
Enhanced expression of mRNA for FK506-binding protein 5 in bone marrow CD34 positive cells in patients with rheumatoid arthritis.

OBJECTIVE Recent studies have disclosed that several genes are up-regulated in bone marrow (BM) mononuclear cells from rheumatoid arthritis (RA) patients. However, it remains unclear whether such abnormalities result from systemic inflammation or from abnormalities at stem cell level. The current study therefore examined the expression of several representative genes, including amphiregulin (AREG), chemokine receptor 4 (CXCR4), and FK506-binding protein 5 (FKBP5) in RA BM CD34+ cells. METHODS BM samples were obtained from 52 patients with RA and 35 patients with osteroarthritis (OA) during joint operations. CD34+ cells were purified from the BM mononuclear cells by positive selection with magnetic beads. The mRNA expression for AREG, CXCR4, and FKBP5 was measured using quantitative real-time PCR. RESULTS The expression of mRNA for FKBP5, but not that of AREG or CXCR4, was significantly higher in RA BM CD34+ cells than in OA BM CD34+ cells. The FKBP5 mRNA expression level was not correlated with serum CRP or treatment. In addition, tumour necrosis factor-alpha did not enhance the expression of FKBP5 mRNA in BM CD34+ cells from healthy donors. CONCLUSION The results suggest that the enhanced expression of FKBP5 in BM CD34+ cells might be an intrinsic abnormality of RA BM CD34+ cells, whereas the enhanced expression of AREG and CXCR4 in BM mononuclear cells might be secondary to systemic inflammation.
A Model for Designing Objective‐oriented Training Evaluations

Suggests that course evaluations are an often overlooked part of training, and that instructional designers and other HRD professionals often choose to use standardized forms in an attempt to obtain feedback on how well a course was presented and received. Points out that, though standardized evaluations present some value, they do not provide the levels of detailed information required to measure – quantitatively as well as qualitatively – the overall success of the programme. Presents a model which emphasizes development of course evaluations linked to the objectives the training is designed to attain. Discusses competence – as well as behaviourally based objectives – along with the need to make objectives realistic and attainable. Concludes by highlighting the necessity to use custom‐designed evaluations, tied to course objectives as a means not only for measuring functional and/or behavioural improvements but also as a means for modifying the course as future needs arise.
Changes in Lipids and Inflammatory Markers after Consuming Diets High in Red Meat or Dairy for Four Weeks

There is a body of evidence linking inflammation, altered lipid metabolism, and insulin resistance. Our previous research found that insulin sensitivity decreased after a four-week diet high in dairy compared to a control diet and to one high in red meat. Our aim was to determine whether a relationship exists between changes in insulin sensitivity and inflammatory biomarkers, or with lipid species. Fasting Tumor Necrosis Factor alpha (TNF-α), Tumor Necrosis Factor Receptor II (sTNF-RII), C-reactive protein (CRP), and lipids were measured at the end of each diet. TNF-α and the ratio TNF-α/sTNF-RII were not different between diets and TNF-α, sTNF-RII, or the ratio TNF-α/sTNF-RII showed no association with homeostasis model assessment-estimated insulin resistance (HOMA-IR). A number of phosphatidylethanolamine (PE) and phosphatidylinositol (PI) species differed between dairy and red meat and dairy and control diets, as did many phosphatidylcholine (PC) species and cholesteryl ester (CE) 14:0, CE15:0, lysophosphatidylcholine (LPC) 14:0, and LPC15:0. None had a significant relationship (p = 0.001 or better) with log homeostasis model assessment-estimated insulin resistance (HOMA-IR), although LPC14:0 had the strongest relationship (p = 0.004) and may be the main mediator of the effect of dairy on insulin sensitivity. LPC14:0 and the whole LPC class were correlated with CRP. The correlations between dietary change and the minor plasma phospholipids PI32:1 and PE32:1 are novel and may reflect significant changes in membrane composition. Inflammatory markers were not altered by changes in protein source while the correlation of LPC with CRP confirms a relationship between changes in lipid profile and inflammation.
Suppression of negative and expression of positive emotions: Divergent effects of emotional display rules in a hostile service interaction

Cross-sectional studies have found that demands to express positive emotions have more desirable associations with service providers' well-being and service quality than demands to suppress negative emotions. Despite their potential importance, emotional labour research has not clarified the nature of these differences yet. The present experimental study aimed to investigate the causal effects of demands to suppress negative emotions, demands to express positive emotions, and their interaction in a simulated service interaction. In total, 101 participants were instructed to play the role of a service employee, who had to interact with a dissatisfied and uncivil customer. Participants were randomly given information that the organization expected them to (1) express genuinely felt emotions, (2) suppress negative emotions, (3) express positive emotions, or (4) suppress negative emotions and express positive emotions. Results confirmed that demands to suppress negative emotions decreased well-being, whereas demands to express positive emotions led to a better service quality. Moreover, service quality was only increased if demands to express positive emotions were not supplemented by demands to suppress negative emotions. These findings suggest that not only demands to express positive emotions can reduce the cost/benefit ratio of emotional labour, but also organizations should avoid imposing demands to suppress negative emotions.
Adult Age Differences in Covariation of Motivation and Working Memory Performance: Contrasting Between-Person and Within-Person Findings

Developmental theorists have proposed for a long time that the prevailing focus on stable individual differences has obstructed the discovery of short-term covariations between cognitive performance and contextual influences within individuals that may help to uncover mechanisms underlying long-term change. As an initial step to overcome this imbalance, we observed measures of motivation and working memory (WM) in 101 younger and 103 older adults across 100 occasions. Our main goals were to (1) investigate day-to-day relations between motivation and WM, (2) show that these relations differ between groups of younger and older adults, and (3) test whether the within-person and between-person structures linking motivational variables to WM are equivalent (i.e., the ergodicity assumption). The covariation between motivation and WM was generally positive in younger adults. In contrast, older adults showed reduced variability in motivation, increased variability across trials, and small reliability-adjusted correlations between motivation and WM. Within-person structures differed reliably across individuals, defying the ergodicity assumption. We discuss the implications of our findings for developmental theory and design, stressing the need to explore the effects of between-person differences in short-term covariations on long-term developmental change.
Injurious assumptions: Butler, subjectification and gen(d)erational poverty

Using Judith Butler's theory of performative subjection, this paper examines the injurious attitudes of three staff members at an outer-metropolitan high school who are heavily involved in the enactment and monitoring of Senior Education and Training (SET) Plan interviews for the Queensland Certificate of Education. It is argued that teachers at the case study school have inscripted students to the category of ‘underprivileged’, which in this context is labelled as ‘generational poverty’. Membership to this category has, in my view, positioned students as ‘backward’ and behind in schooling capability, thus placing them on a storyline trajectory associated with low paid labour market participation, reliance on government welfare and/or unemployment. I draw on teacher comments referring to students as possessing ‘deficit skills’ to form this argument. In order to help ‘break’ this cycle of poverty, staff involved in the SET Plan interviews have subsequently positioned themselves as ‘helpers’ by attempting to give curriculum pathway advice which they see as ‘appropriate’ for the students at the school. This advice and help with subject selection and curriculum pathway planning, while seemingly well intentioned, reinscribes gendered stereotypes and thus aids in the reproduction of schooling and post-schooling inequality for both sexes, but especially for girls.
Radio Loudness of Active Galactic Nuclei: Observational Facts and Theoretical Implications

We investigate how the total radio luminosity of AGN-powered radio sources depends on their accretion luminosity and the central black hole mass. Our studies cover about 7 orders of magnitude in accretion luminosity (expressed in Eddington units, i.e., as Eddington ratios) and the full range of AGN black hole masses. We find that AGNs form two distinct and well-separated sequences on the radio-loudness-Eddington-ratio plane. The "upper" sequence is formed by radio-selected AGNs, and the "lower" sequence contains mainly optically selected objects. Whereas an apparent "gap" between the two sequences may be an artifact of selection effects, the sequences themselves mark the real upper bounds of radio loudness of two distinct populations of AGNs: those hosted respectively by elliptical and disk galaxies. Both sequences show the same dependence of the radio loudness on the Eddington ratio (an increase with decreasing Eddington ratio), which suggests that the normalization of this dependence is determined by the black hole spin. This implies that central black holes in giant elliptical galaxies have (on average) much larger spins than black holes in spiral/disk galaxies. This galaxy-morphology-related radio dichotomy breaks down at high accretion rates where the dominant fraction of luminous quasars hosted by elliptical galaxies is radio quiet. This led to speculations in the literature that formation of powerful jets at high accretion rates is intermittent and related to switches between two disk accretion modes, as directly observed in some black hole X-ray binaries. We argue that such intermittency can be reconciled with the spin paradigm, provided that successful formation of relativistic jets by rotating black holes requires collimation by MHD outflows from accretion disks.
Gambling Disorder during Dopamine Replacement Treatment in Parkinson's Disease: A Comprehensive Review

Gambling Disorder (GD) is characterized by “the failure to resist gambling impulses despite severe personal, family or occupational consequences”. In the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V), GD replaces the DSM-IV diagnosis of Pathological Gambling (PG). GD estimated prevalence ranges between 0.4% and 3.4% within the adult population and it seems to be more common in patients with Parkinson's disease (PD). In this population, GD recently has become more widely recognized as a possible complication of dopamine agonist (DA) therapy. This association has aroused great interest for the dramatic impact GD has on patients' quality of life. Management of PG in patients with PD could be demanding. It is based on patient and caregiver education, modification of dopamine replacement therapy, and in some cases psychoactive drug administration. In this review article, the authors provide an overview of GD pathogenesis during DA therapy as well as a summary of available treatment options.
Global Tracking via Output Feedback for Nonlinear MIMO Systems

In this note we present a constructive method for the design of global asymptotic tracking control for a class of MIMO nonlinear systems by output feedback. The class of systems considered is a special case of those in nonlinear observer form and coincides with the Output Feedback Form when there is only one input and one output. This approach generalizes a SISO method which uses filtered transformations and backstepping. The technique presented here may be useful in accommodating subsystem coupling in other MIMO design contexts. We demonstrate our method by example and observe several interesting features that distinguish it from the SISO case.
Inclusive Schools for an Inclusive Society

Gary Thomas (Professor of Special Needs at The University of the West of England, Bristol) contends that mainstream schools should assume responsibility for all children, not only as there is firm empirical evidence to show that inclusive schools are good for all children, but more importantly because of the legitimacy, the justice and the timeliness of the inclusive position. Initially he discusses a definition of inclusion and notes how its meaning is different from that of integration, and goes on to examine some of the evidence for the success of inclusion in schools. He then places its success in the context of the values which lead to an espousal of inclusion, considers an inclusive ethic against the more general move to inclusion in society, and sketches out the theoretical and political context. He concludes by suggesting that the inevitability of the change to inclusion means that administrators should plan constructively for desegregation rather than fighting rearguard actions against it.
Children's nomination of friendly places in an urban neighbourhood in Shiraz, Iran

This study investigates how children conceive of and value the outdoor environment as a child-friendly one with particular reference to an urban neighbourhood in Shiraz, Iran. It utilizes Chatterjee's (2005. “Children's Friendship with Place: A Conceptual Inquiry.” Children, Youth and Environments 15 (1): 1–26) place friendship construct to find out friendly places and their attributes from children's points of view. Semi-structured interviews were conducted with 106 middle childhood children. Findings suggest that a child-friendly neighbourhood is made up of diverse places that children use to meet their different needs. However, formal and informal open spaces, private precincts, and streets in the neighbourhood afforded highest contributions to place friendship.
MiR-133a Is Functionally Involved in Doxorubicin-Resistance in Breast Cancer Cells MCF-7 via Its Regulation of the Expression of Uncoupling Protein 2

The development of novel targeted therapies holds promise for conquering chemotherapy resistance, which is one of the major hurdles in current breast cancer treatment. Previous studies indicate that mitochondria uncoupling protein 2 (UCP-2) is involved in the development of chemotherapy resistance in colon cancer and lung cancer cells. In the present study we found that lower level of miR133a is accompanied by increased expression of UCP-2 in Doxorubicin-resistant breast cancer cell cline MCF-7/Dox as compared with its parental cell line MCF-7. We postulated that miR133a might play a functional role in the development of Doxorubicin-resistant in breast cancer cells. In this study we showed that: 1) exogenous expression of miR133a in MCF-7/Dox cells can sensitize their reaction to the treatment of Doxorubicin, which is coincided with reduced expression of UCP-2; 2) knockdown of UCP-2 in MCF-7/Dox cells can also sensitize their reaction to the treatment of Doxorubicin; 3) intratumoral delivering of miR133a can restore Doxorubicin treatment response in Doxorubicin-resistant xenografts in vivo, which is concomitant with the decreased expression of UCP-2. These findings provided direct evidences that the miR133a/UCP-2 axis might play an essential role in the development of Doxorubicin-resistance in breast cancer cells, suggesting that the miR133a/UCP-2 signaling cohort could be served as a novel therapeutic target for the treatment of chemotherapy resistant in breast cancer.
Injury Risk and Noise Exposure in Firefighter Training Operations.

INTRODUCTION Firefighters have high rate of injuries and illnesses, as well as exposures to high levels of noise. This study explored the relationship between noise exposure and injury among firefighters. METHODS We recruited firefighters undergoing vehicle extrication and structural collapse emergency response training at a highly realistic training facility. Demographics, health status, body mass index (BMI), and history of serious injuries (i.e. injuries requiring first aid treatment, treatment in a medical clinic or office, or treatment at a hospital) were assessed at baseline, and daily activities, injury events, and near misses were assessed daily via surveys. Participants' noise exposures were monitored for one 24-h period using noise dosimeters. We used a mixed-effects logistic regression model to estimate the odds of injury events and near misses associated with noise exposure as an independent variable. RESULTS Of 56 subjects, 20 (36%) reported that they had ever suffered a serious injury during firefighting activities, and 9 (16%) reported a serious injury within the past year. We estimated rates of 6.6 lifetime serious injuries per 100 FTE 16.1 serious injuries per 100 FTE within the past year. Our models indicated a significant increase in injury events and near misses among those with higher BMI, and as well as a dose-response relationship between near misses/injuries and increasing noise levels. Noise levels >90 dBA in the 30 min prior to time of injury or near miss were associated with substantially increased odds ratios for injury or near miss. Our models further indicated that perceived job demands were significantly associated with increased risk of injury or near miss. CONCLUSION Our results suggest that noise exposures may need to be incorporated into injury prevention programs for firefighters to reduce injuries among this high-risk occupational group.
The salience and utility of school sex education to young men

This paper focuses on young men's views on the school sex education they have received, the influence of this sex education on their intended or actual behaviour, and the extent to which other sources of information complement or supplement school sex education. Thirty‐five in‐depth interviews and eight group discussions were conducted with male pupils from six schools in the east of Scotland. Most of those interviewed did cite school as a useful source in learning about sex. The most commonly named highlights were learning more about what girls think about sexual matters and learning how to use a condom. Nine described how something they had learned in school sex education had changed the way they had behaved in a sexual encounter. A further eight, who had not experienced sexual intercourse, talked about how they thought sex education would influence their behaviour in a positive way in the future. The most common criticism of sex education was that it was not explicit enough. Although friends and/or television were named by the majority of young men as useful, for most young men school sex education appeared to be the only substantive source of information they had received on sexual matters.
Maximal Voluntary Static Force Production Characteristics of Skeletal Muscle in Children 8-11 Years of Age

Abstract Maximal voluntary isometric muscle contraction force-time curves for 32 normal, healthy children, age 8-11 years, 15 girls and 17 boys, performing three tasks representing separate muscle groups-finger flexors, forearm flexors, and forearm extensors—were recorded over trials and over days. Children's pattern of force production and degree of consistency over trials and days has not been reported in the literature. The primary objective was to identify curve components reproduced with sufficient consistency over trials and days to suggest possible value for providing new and unique information regarding muscle function. Each task was recorded three consecutive trials per day over two days separated by one week. Analog tracings of instantaneous and integrated force were obtained using a Daytronic Linear Voltage Transformer in series with a Brush Mark 280 recorder. Trial to trial and day to day consistency in force production by each muscle group represented by 14 curve variables was assessed using .
Do Birds of a Feather Flock Together? An Examination of Calling, Congruence, Job Design and Personality as Predictors of Job Satisfaction and Tenure

This study explored whether congruence, calling, job characteristics or personality were better predictors of job satisfaction and tenure. The sample consisted of 1968 employees across four different job roles: sales engineers (N=309), graphic designers (N=383), teachers (N=481) and clergy (N=795). Data was collected as part of a selection and development centre battery. Results found evidence of calling, with clergy reporting significantly higher levels of work satisfaction and tenure, despite the absence of some personality predictors (i.e. conscientiousness) and job characteristics (task identity, feedback). In general personality [particularly conscientiousness (+) and neuroticism (-)] along with job characteristics (variety and autonomy) were the most likely predictors of satisfaction across the different roles. No evidence could be found that congruence predicted work satisfaction or tenure. Results have implications for renewed interest in the role of calling according to its original definition and question the role of congruence in determining best fit especially in the context of vocational assessments.
The Relationship Between Indirect and Physical Aggression on Television and in Real Life

Viewing indirect aggression on television has been shown to have negative short-term effects on a viewer's subsequent aggressive behavior; however, the longer term relationship between viewing indirect aggression on television and in real life has not yet been examined. Three hundred and forty-seven adolescents, aged 11–14, were asked to list their five favorite television programs. These programs were analyzed for the amount and type of aggression they contained. Peer-nominated indirect aggression was predicted by other aggressive behavior, sex, and televised indirect aggression. In particular, indirectly aggressive girls viewed more indirect aggression on television than any other group. Peer-nominated physical aggression was predicted by other aggressive behavior and sex, but not by televised physical or indirect aggression. This study provides a starting point for future long-term research on the effect of viewing indirect aggression in the media.