Miracle-dz/UniFAR-FTUs huggingface dataset:
The Safety Regulation of U.S. Nuclear Power Plants: Violations, Inspections, and Abnormal Occurrences

Data from more than 1,000 inspections to the Nuclear Regulatory Commission form the basis for an investigation into the nature of safety regulation at U.S.commercial nuclear reactors. Poisson (and binary choice) models of the rate of occurrence of violations during each inspection period are specified and are extended to control for nondetection and for the possibility that violations persist from one inspection to the next. These models are used to study the factors associated with noncompliance, relative rankings of plants according to propensity to violate, the variation in detection rates among NRC inspectors, and the relationship between undetected violations and abnormal occurrences.
Revisiting the Relation Between Decentralization and Growth in the Context of Marketization

Decentralization in countries in transition did not take place in isolation from other marketization reforms. Although the latter have been shown to support growth, the literature on fiscal decentralization and growth is not conclusive. Our work revisits this relationship within the wider context of reform. This article uses a generalized method of moments (GMM) on a panel of eighteen East European countries in transition for the period 2002–2008. We show that decentralization has a positive impact on growth conditional to local government’s autonomy to manage the structure of local public expenditure toward its recurrent component to open the way for more private sector engagement in service delivery. Moreover, our results confirm the reverse causality between local financial indicators and growth: A higher level of growth leads to a lower level of government intervention and a smaller public sector, which confirm previous results.
Management of mass casualty events: the Israeli experience.

PURPOSE Among all the emergency scenarios, the most common medical emergency event in Israel is the conventional mass casualty event (MCE). This article describes the Israeli model of emergency preparedness and management at the national level, step-by-step emergency management at the hospital level, and nursing roles in emergency events. SETTING Israel has a unique national and local model of organizing and managing an emergency event, characterized by a central national organization that is responsible for emergency policy, management, coordination, quality control, and ongoing improvement. CONCLUSIONS Well-planned emergency preparedness training for a multidisciplinary staff is crucial. Nurses play significant roles both clinically and managerially in leading and organizing emergency events on all levels. CLINICAL RELEVANCE Lessons gained from the special model of management of MCEs in Israel, particularly regarding unique nursing roles, may be considered for applicability in other countries.
Polish Young Peoples' Narratives: Impacts of Living and Studying in the UK

Migration plays an important role in shaping contemporary society in the European Union (EU), with specific countries being affected differently. As a result of the most recent expansion of the EU in 2004, the United Kingdom (UK) has experienced an influx of economic migrants from former ‘Eastern Block’ countries, including many young people from Poland. This study explores the experiences of a group of nine young adults living, studying and working in the UK. Three of the nine participants were co-researchers in the participatory action research framework employed, equipping the researchers with the tools to undertake a narrative enquiry. The resultant metanarrative outlines emergent themes, illustrated by participants’ words. The themes include reasons for coming to and staying in the UK; first impressions of and changing opinions about life in the UK; the impact of visits to Poland and plans for the future. The data provide a unique developmental perspective of the changing experiences related to living in the UK, and give some insight into the life impacts of migration in contemporary Europe.
Ingenol mebutate for the treatment of actinic keratosis: effectiveness and safety in 246 patients treated in real-life clinical practice

Abstract Introduction: The aim of the study was to evaluate the results on effectiveness and safety of topical treatment for actinic keratosis (AK) with ingenol mebutate gel (IMG) in real-life conditions and to perform an analysis of the factors that may influence the treatment outcomes. Materials and methods: Retrospective study of patients with non-hyperkeratotic AK lesions prescribed with IMG in Spain according to clinical practice. Dermatologists reported the characteristics of patients and AK at baseline, and the findings observed up to 60 d after treatment. Results and conclusions: A total of 260 treatments in 246 patients with a mean (SD) age 70.6 (10.4) years were reviewed. The number of clinically visible AK in the treated area decreased from 6.16 (3.02) to 1.22 (2.02) (p < .001) lesions with an average reduction of 84%. Univariate analysis showed higher reduction rates when IMG was applied in the face/scalp (p = .026), in women (p = .041), and in patients under 70 years of age (p = .033). According to multivariate analysis, advanced age was associated with worse clearance rates (p = .038). However, besides statistical significance, we can conclude that gender (female) and age (under 70 years-old) show a tendency to have better efficacy outcomes but without clinical relevance. Topical IMG was generally well tolerated and had positive cosmetic results after 60 d. Age influences on IMG effectiveness for AK and LSRs were correlated with higher effectiveness ratios.
Human Intestinal Mast Cells Are Capable of Producing Different Cytokine Profiles: Role of IgE Receptor Cross-Linking and IL-41

Mast cells are recognized as a new type of immunoregulatory cells capable of producing different cytokines. So far, little is known about the cytokine profile of mature human mast cells isolated from intestinal tissue and cultured in the presence of stem cell factor (SCF). We observed that these cells express the proinflammatory cytokines TNF-α, IL-1β, IL-6, IL-8, IL-16, and IL-18 without further stimulation. Both IgE-dependent and IgE-independent agonists (e.g., Gram-negative bacteria) enhanced expression of TNF-α. Another set of cytokines consisting of IL-3, IL-5, IL-9, and IL-13 was expressed following activation by IgE receptor cross-linking. If mast cells were cultured in the presence of IL-4 and SCF, the production and release of IL-3, IL-5, and IL-13 was increased up to 4-fold compared with mast cells cultured with SCF alone. By contrast, IL-6 expression was completely blocked in response to culture with IL-4. In summary, our data show that mature human mast cells produce proinflammatory cytokines that may be up-regulated following triggering with IgE-independent agonists such as bacteria, whereas activation by IgE receptor cross-linking results in the expression of Th2-type cytokines. IL-4 enhances the expression of Th2-type cytokines but does not affect or even down-regulates proinflammatory cytokines.
What are we thinking of? A critical overview of approaches to developing academic literacy in South African higher education

In South African higher education, the development of academic literacy is often seen to be the responsibility of those working in the field that is known as ‘academic development’. This paper uses an analysis of submissions to the 2012 annual conference of the Higher Education Learning and Teaching Association of Southern Africa, the forum most used by those working in the field to present their work, (i) to examine critically the way the construct of academic literacy is understood by practitioners in the field and (ii) to consider the approaches to the development of literacy to which these understandings lead. Key words : academic literacies, academic development, higher education, reading, writing, skills, practices
Measuring Goodness of Fit for the Double-Bounded Logit Model

The traditional approaches of measuring goodness of fit are shown to be inappropriate in the case of the double-bounded logit model. An alternate approach called the "sequential classification procedure" is presented as a possible alternative to the standard tests. The double-bounded logit model is reviewed along with the standard goodness-of-fit measures. The sequential classification procedure and its features are presented in the context of an empirical example.
Characterization of microbial community structure in a hybrid biofilm-activated sludge reactor for simultaneous nitrogen and phosphorus removal.

The microbial communities in a hybrid biofilm-activated sludge reactor (HY) for nitrogen and phosphorus removal were characterized by 16S rRNA-based clone libraries and phylogenetic analysis. The hybrid reactor removed over 90% of COD, 92% of total nitrogen (TN) and 95% of total phosphorus (TP) from the municipal wastewater, respectively. The mean removal rates of COD, TN, and TP in the conventional suspended activated sludge reactor were above 80%, 80% and 94%, respectively. Community structures were determined by phylogenetic analyses of six clone libraries (each nearly 100 clones). The dominant bacterial group with which clones were affiliated to the beta subclass of the Proteobacteria (31% to approximately 77%), following the Bacteroidetes group (10% to approximately 34%). In addition, several clone groups affiliated with unknown bacterial assemblages were identified in the clone libraries. Acinetobacter sp. , which was thought to had played an important role in phosphate removal systems, was scarcely represented by clone sequences in both libraries. Differences in community structure were observed between the hybrid reactor and activated sludge reactors. Such differences may account for the differing wastewater treating capabilities of the two different systems.
ACE inhibition facilitates sodium and water excretion during PEEP in conscious volume-expanded dogs.

Increased activity of the renin-angiotensin system may be involved in sodium and water retention during controlled mechanical ventilation (CMV) with positive end-expiratory pressure (PEEP). We therefore evaluated renal, hemodynamic, and hormonal effects of an acute angiotensin-converting enzyme inhibition (ACEI) during PEEP and extracellular volume expansion in five trained chronically tracheotomized dogs. Three protocols were performed: control, 4 h spontaneous breathing with continuous positive mean airway pressure (Paw) of 4 cmH2O (CPAP 4); CMV 20, CPAP for 1st h, CMV with 20 cmH2O Paw for 2 h (2nd and 3rd h), and 1 h of CPAP (4th h); and CMV20-ACEI, ACEI (Ramipril, 2 mg/kg body wt) followed by the same protocol as in CMV 20. During control, sodium excretion (UNaV) and urine volume (V) increased continuously to 56.2 +/- 2.7 (SE) mumol.min-1.kg body wt-1 and 482 +/- 23 microliters.min-1.kg body wt-1, respectively. UNaV and V increased less during PEEP in CMV 20 and CMV 20-ACEI. However, significantly more sodium and water were retained in CMV 20 than in CMV 20-ACEI (2.3 +/- 0.3 vs. 1.0 +/- 0.3 mmol/kg body wt, and 20 +/- 3 vs. 11 +/- 2 ml/kg body wt) because of a decrease of glomerular filtration rate and fractional UNaV in CMV 20. Heart rate did not change in control, CMV 20, or CMV 20-ACEI. Mean arterial pressure increased during control by 13 mmHg, did not change during CMV 20, and was decreased by 7 mmHg in CMV 20-ACEI. (ABSTRACT TRUNCATED AT 250 WORDS)
Competing for scarce talent in a liberalised environment: evidence from the aviation industry in Africa

Although the last few years have witnessed a burgeoning stream of research on interfirm mobility of employees, the extant research has remained relatively silent on both its dynamics and effects on the performance of firms domiciled in emerging economies. Using a qualitative case study approach, this article attempts to illuminate our understanding of both issues. It places particular emphasis on the examination of the dynamics of employees' interfirm mobility in the airline industry in Africa. The findings reveal the diverse ways in which the liberalisation in the industry has created a new competitive landscape with far-reaching consequences for firms. Essentially, firms now have to compete intensely for the scarce human capital. The theoretical and managerial implications of these findings are discussed.
Collectivity of drinking behavior among adolescents: An analysis of the Norwegian ESPAD data 1995-2011

Aims The aim of the current study was to test empirically two predictions from Skog's theory of collectivity of drinking behavior, using time series data from Norwegian adolescents. The two specific predictions were: 1) A change in mean alcohol consumption is positively associated with a change in the proportion of heavy drinkers, and 2) A change in mean alcohol consumption is positively associated with a change at all consumption levels. Data & Methods The present analyses are based on ESPAD data collected from Norwegian adolescents (15-16 years) in 1995, 1999, 2003, 2007 and 2011. The relationship between mean consumption and the proportion of heavy drinkers was analyzed by regressing the proportions of heavy drinkers at each time point on the consumption means at each time point. In order to assess whether adolescents at all consumption levels, from light to heavy drinkers, changed collectively as mean consumption changed, we regressed log-transformed consumption means on the log-transformed percentile values (P25, P50, P75, P90 and P95). The analysis was restricted to adolescents who had consumed alcohol in the last 30 days (total n = 7554). Results The results showed a strong relationship between mean alcohol consumption and the proportion of heavy drinkers. An increase in mean consumption was also associated with an increase at all consumption levels, from light to heavy drinkers. Conclusion The results of the current study are in line with the theory of collectivity of drinking behavior. The findings of this study suggest that by reducing the total consumption of alcohol among adolescents, consumption and risk of harm may be reduced in all consumer groups.
Long-term outcome of anti-tumor necrosis factor alpha blockade in the treatment of juvenile spondyloarthritis.

OBJECTIVES A significant proportion of patients with juvenile spondyloarthritis (JSpA) are refractory to treatment with established medications. The objective of this study was to assess long-term efficacy of treatment with anti-TNF agents in patients with JSpA. METHODS An observational study of 16 patients with JSpA from 3 centres treated with infliximab (n=10) and etanercept (n=6) was performed, with a median follow-up period of 7.2 years. Prospective data was collected according to a standardized protocol. Outcomes examined were TEC, TAJC, markers of inflammation (ESR, CRP), functional assessments (C-HAQ, BASDAI, BASFI), and ongoing requirement for anti-TNF treatment. RESULTS 13/16 patients (83%) had achieved clinical remission 6 months into the treatment. Improvement was sustained over time, with a median TAJC and TEC of 0 at any time point after 6 weeks. 6/16 patients (38%) showed a flare of arthritis after a median of 3.5 years. Two patients with hip disease prior to treatment required an arthroplasty 3 and 8 years post anti-TNF initiation. Patients showed progression of sacroiliitis with median modified New York score of 1 (range 0-3) at time of diagnosis and 3 (range 0-4) at last follow-up (p=0.002). Median BASDAI at last follow up was 1.6, median BASFI 3.1. Two patients developed transient reactions (one generalised, one local); no patient developed other adverse effects during the study. CONCLUSIONS Anti-TNF treatment in JSpA refractory to standard treatment results in good long-term disease control except for pre-existing hip disease. However, radiographic evidence suggests inferior efficacy for control of sacroiliac joint disease.
Assessment of uncertainty in computer experiments from Universal to Bayesian Kriging

Kriging was first introduced in the field of geostatistics. Nowadays, it is widely used to model computer experiments. Since the results of deterministic computer experiments have no experimental variability, Kriging is appropriate in that it interpolates observations at data points. Moreover, Kriging quantifies prediction uncertainty, which plays a major role in many applications. Among practitioners we can distinguish those who use Universal Kriging where the parameters of the model are estimated and those who use Bayesian Kriging where model parameters are random variables. The aim of this article is to show that the prediction uncertainty has a correct interpretation only in the case of Bayesian Kriging. Different cases of prior distributions have been studied and it is shown that in one specific case, Bayesian Kriging supplies an interpretation as a conditional variance for the prediction variance provided by Universal Kriging. Finally, a simple petroleum engineering case study presents the importance of prior information in the Bayesian approach. Copyright © 2009 John Wiley & Sons, Ltd.
Analysis of single unknown volume integral equation for general scatterers

The volume integral equation method is used to analyze electromagnetic scattering from arbitrarily shaped three-dimensional homogeneous objects whose permittivity and permeability differ from those of background medium. We consider three different types of formulations, the DB-formulation with flux densities as unknowns, the EH-formulation with fields as unknowns, and EE- and HH-formulations that contain only single unknown, either electric or magnetic field. The properties of the formulations are investigated with numerical examples. Numerical results show that at least fully linear curl conforming basis functions must be used when applying the single unknown volume intergal equation for general scatterers.
I M P O S S I B I L I T Y, I M P R AC T I C A B I L I T Y, AND FRUS T RATION

Three fundamental concepts underlie the principles that should govern unexpectedcircumstances cases. (1) A contract consists not only of the writing in which it is partly embodied, but also includes, among other things, certain kinds of tacit assumptions. (2) These assumptions may be either event-centered or magnitude-centered. (3) The problems presented by unexpected-circumstances cases should be viewed in significant part through a remedial lens. The principles that rest on these concepts can be broadly summarized as follows. A shared nonevaluative tacit assumption that a given circumstance will persist, occur, or not occur during the contract time should provide a basis for judicial relief where the assumption would have affected the promisor’s obligations had it been made explicit. If the promisor was neither at fault for the occurrence of the unexpected circumstance, nor in control of the conditions that led to the occurrence, she should not be liable for expectation damages. The promisor should, however, be liable for restitutionary damages, because it would be unjust to allow the promisor to both be excused from performance and retain any benefits that she received under the contract. Alternatively, the promisor should be liable for reliance damages where she is at fault for the creation of the unexpected circumstance, but the fault is minor; where the promisor is in control of the conditions that led to the occurrence of the unexpected circumstances; or where an objective of the contract was to reserve for the promisor the promisee’s time, labor, or productive capacity. A seller should also be entitled to judicial relief if as a result of a dramatic and unexpected rise in her costs, performance would result in a financial loss that is significantly greater than the risk of loss that the parties would reasonably have expected that the seller
The Interaction between Candida krusei and Murine Macrophages Results in Multiple Outcomes, Including Intracellular Survival and Escape from Killing

ABSTRACT Candida krusei is a fungal pathogen of interest for the scientific community for its intrinsic resistance to fluconazole. Little is known about the interaction of this yeast with host immune cells. In this work, we have characterized the outcome of the interaction between C. krusei and murine macrophages. Once C. krusei was internalized, we observed different phenomena. In a macrophage-like cell line, C. krusei survived in a significant number of macrophages and induced filamentation and macrophage explosion. Phagocytosis of C. krusei led to actin polymerization around the yeast cells at the site of entry. Fluorescent specific staining with anti-Lamp1 and LysoTracker indicated that after fungal internalization, there was a phagolysosome maturation defect, a phenomenon that was more efficient when the macrophages phagocytosed killed yeast cells. Using cell line macrophages, we also observed macrophage fusion after cell division. When we used primary resident peritoneal macrophages in addition to macrophage explosion, we also observed a strong chemotaxis of uninfected macrophages to regions where C. krusei-infected macrophages were present. We also noticed yeast transfer phenomena between infected macrophages. Primary macrophages inhibited pseudohypha elongation more efficiently than the macrophage-like cell line, suggesting that C. krusei infection was better controlled by the former macrophages. Primary macrophages induced more tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) than the macrophage-like cell line. Our results demonstrate that C. krusei can exploit the macrophages for replication, although other different outcomes are also possible, indicating that the interaction of this pathogen with phagocytic cells is very complex and regulated by multiple factors.
An Analysis of Public Expenditure on Education in Pakistan

This study attempts to analyse the priorities accorded to Education by the federal as well as the provincial governments. Since education is in large part a provincial responsibility, a comparative analysis of the performance of the public sector education in the four provinces of Pakistan would be useful to provide feedbacks to the provincial administrations of relative strengths and weaknesses of their educational system. Also, differences in priorities and performance among provinces provide useful insights, and, more importantly, raise many questions for planners. Such an analysis is also necessary for overall resource allocation. The analysis will be extended to district level but confined to Punjab and Sindh due to data constraints. The study will also examine the disparities in budget allocations to education in the two provinces.
Small Differences That Matter: Mistakes in Applying to College

In 1997, the ACT increased the number of free score reports it provided to students from three to four, maintaining a $6 marginal cost for each additional report. In response to this $6 cost change, ACT-takers sent many more score reports and applications relative to SAT-takers. They widened the range of colleges they sent scores to, and low-income ACT-takers attended more-selective colleges. Back-of-the-envelope calculations suggest that the policy substantially increased low-income students’ expected earnings. This sizable behavioral change in response to such a small cost change suggests that in this setting, small policy perturbations can have large effects on welfare.