Miracle-dz/UniFAR-FTUs huggingface dataset:
Familial Characteristics of Internet Overuse Adolescents

Objectives：The objective of this study is to clarify the family environments, parent-adolescent communication, family violence, parental conflict, parental alcohol drinking that contribute to internet use of adolescent Methods：Subjects were middle and high school students in Gang-seo gu, Seoul city (N=998). Self-rating questionnaire included demographic data, internet addiction scale, family adaptability cohesion evaluation scale III, parent-adolescent communication inventory, conflict tactics scales 2 and children of alcoholics screening test. Results：1) There were statistically significant differences in CAST, family violence, communication between family members and family adaptability cohesion scale between addicted group and non-addicted group. 2) Most ignificantly correlated variants for internet addiction were problematic communication of parents and psychological aggression. 3) Multiple regression analysis showed that problematic communication of parents, psychological aggression and CAST could explain 10.1% of internet addictions. Conclusion：This study was designed specifically to focus on the various domains of adolescents’ family environment that may influence the overuse of internet. It proved that moderate level of adaptability, cohesion and open communication in a parentchild relationship can prevent the overuse of internet. On the other hand, aggressive language spoken between the two parents and their alcohol abuse can aggravate the overuse of internet
SMART: a web-based tool for the study of genetically mobile domains

SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de ). More than 400 domain families found in signalling, extra-cellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.
Intéressement et attitudes des salariés dans l'entreprise

Les systemes de remuneration sont generalement percus comme des moyens de peser sur la motivation, la satisfaction et l'implication des salaries. Ecartant l'etude de la motivation, dont une bonne partie echappe a l'entreprise, cette contribution examine le role de l'interessement aux resultats de l'entreprise sur les attitudes des employes. Il n'existe pas de relation simple en raison des multiples correlations qu'entretiennent entre elles la plupart des variables explicatives. Toutefois, la recherche indique une liaison entre le regime de participation financiere etudie et la satisfaction, et rejette l'hypothese d'une relation entre un tel systeme de remuneration et l'implication
The Body Doesn't Lie

Abstract This paper examines changes in levels of stress for individuals participating in a rappelling activity. Due to the inherent risk and physical nature of recreational activities such as mountaineering, rock climbing, and rappelling, it is often challenging to conduct research while participants are actually engaged in the activity. In this study, stress was measured by changes in cortisol within three different time frames (the day before the activity, during the activity, and upon conclusion of the activity). Using non-parametric procedures, results indicated significant differences in Cortisol levels between the various time frames and between male and female participants of the adventure-based program. These findings present new insights regarding what actually is occurring from a body chemistry perspective during an adventure recreation activity.
Galectin-3 Facilitates Cell Motility in Gastric Cancer by Up-Regulating Protease-Activated Receptor-1(PAR-1) and Matrix Metalloproteinase-1(MMP-1)

Background Galectin-3 is known to regulate cancer metastasis. However, the underlying mechanism has not been defined. Through the DNA microarray studies after galectin-3 silencing, we demonstrated here that galectin-3 plays a key role in up-regulating the expressions of protease-activated receptor-1(PAR-1) and matrix metalloproteinase-1(MMP-1) PAR-1 thereby promoting gastric cancer metastasis. Methodology/Principal Findings We examined the expression levels of Galectin-3, PAR-1, and MMP-1 in gastric cancer patient tissues and also the effects of silencing these proteins with specific siRNAs and of over-expressing them using specific lenti-viral constructs. We also employed zebrafish embryo model for analysis of in vivo gastric cancer cell invasion. These studies demonstrated that: a) galectin-3 silencing decreases the expression of PAR-1. b) galectin-3 over-expression increases cell migration and invasion and this increase can be reversed by PAR-1 silencing, indicating that galectin-3 increases cell migration and invasion via PAR-1 up-regulation. c) galectin-3 directly interacts with AP-1 transcriptional factor, and this complex binds to PAR-1 promoter and drives PAR-1 transcription. d) galectin-3 also amplifies phospho-paxillin, a PAR-1 downstream target, by increasing MMP-1 expression. MMP-1 silencing blocks phospho-paxillin amplification and cell invasion caused by galectin-3 over-expression. e) Silencing of either galectin-3, PAR-1 or MMP-1 significantly reduced cell migration into the vessels in zebrafish embryo model. f) Galectin-3, PAR-1, and MMP-1 are highly expressed and co-localized in malignant tissues from gastric cancer patients. Conclusions/Significance Galectin-3 plays the key role of activating cell surface receptor through production of protease and boosts gastric cancer metastasis. Galectin-3 has the potential to serve as a useful pharmacological target for prevention of gastric cancer metastasis.
Recommending Groups to Users Using User-Group Engagement and Time-Dependent Matrix Factorization

Social networks often provide group features to help users with similar interests associate and consume content together. Recommending groups to users poses challenges due to their complex relationship: user-group affinity is typically measured implicitly and varies with time; similarly, group characteristics change as users join and leave. To tackle these challenges, we adapt existing matrix factorization techniques to learn user-group affinity based on two different implicit engagement metrics: (i) which group-provided content users consume; and (ii) which content users provide to groups. To capture the temporally extended nature of group engagement we implement a time-varying factorization. We test the assertion that latent preferences for groups and users are sparse in investigating elastic-net regularization. Experiments using data from DeviantArt indicate that the time-varying implicit engagement-based model provides the best top-K group recommendations, illustrating the benefit of the added model complexity.
Enhanced Fasanella-Servat Procedure for the Graded Repair of Blepharoptosis.

PURPOSE To describe in detail a technique for a modified Fasanella-Servat procedure that provides a simplified method for graded Mueller muscle excision with minimal and controlled tarsal excision. METHODS A retrospective study of 71 patients (102 eyelids) who underwent the modified Fasanella-Servat procedure is reported. Measurements include the preoperative, post-phenylephrine, and postoperative margin-to-reflex distance-1, and postoperative upper eyelid height symmetry as determined by the absolute difference between right- and left-sided margin-to-reflex distance-1. Postoperative complications are reported. RESULTS The average increase in margin-to-reflex distance-1 was 2.4 mm with an average postoperative upper eyelid height symmetry of 0.4 mm. Postoperative asymmetry was 1.5 mm or less in 68 patients, a success rate of 96%. Four patients (6%) exhibited overcorrection, 2 of which required additional surgery. No lagophthalmos or notable eyelid contour abnormalities were seen. CONCLUSIONS The modified Fasanella-Servat technique offers a simple method to isolate and resect Mueller muscle and a minimal segment of tarsus in a quantitative fashion, allowing for a graded repair of blepharoptosis and thereby decreasing the risk of postoperative overcorrection, lagophthalmos, and eyelid contour asymmetry whilst preserving the bulk of tarsus.
Price Rigidity: Microeconomic Evidence and Macroeconomic Implications

We review recent evidence on price rigidity from the macroeconomics literature and discuss how this evidence is used to inform macroeconomic modeling. Sluggish price adjustment is a leading explanation for the large effects of demand shocks on output and, in particular, the effects of monetary policy on output. A recent influx of data on individual prices has greatly deepened macroeconomists’ understanding of individual price dynamics. However, the analysis of these new data raises a host of new empirical issues that have not traditionally been confronted by parsimonious macroeconomic models of price setting. Simple statistics such as the frequency of price change may be misleading guides to the flexibility of the aggregate price level in a setting in which temporary sales, product churning, cross-sectional heterogeneity, and large idiosyncratic price movements play an important role. We discuss empirical evidence on these and other important features of micro price adjustment and ask how they affect the sluggishness of aggregate price adjustment and the economy’s response to demand shocks.
Deep neural networks for Multi-Room Voice Activity Detection: Advancements and comparative evaluation

This paper focuses on Voice Activity Detectors (VAD) for multi-room domestic scenarios based on deep neural network architectures. Interesting advancements are observed with respect to a previous work. A comparative and extensive analysis is lead among four different neural networks (NN). In particular, we exploit Deep Belief Network (DBN), Multi-Layer Perceptron (MLP), Bidirectional Long Short-Term Memory recurrent neural network (BLSTM) and Convolutional Neural Network (CNN). The latter has recently encountered a large success in the computational audio processing field and it has been successfully employed in our task. Two home recorded datasets are used in order to approximate real-life scenarios. They contain audio files from several microphones arranged in various rooms, from whom six features are extracted and used as input for the deep neural classifiers. The output stage has been redesigned compared to the previous author's contribution, in order to take advantage of the networks discriminative ability. Our study is composed by a multi-stage analysis focusing on the selection of the features, the network size and the input microphones. Results are evaluated in terms of Speech Activity Detection error rate (SAD). As result, a best SAD equal to 5.8% and 2.6% is reached respectively in the two considered datasets. In addiction, a significant solidity in terms of microphone positioning is observed in the case of CNN.
Implementation of formative assessment – effects of quality of programme delivery on students’ mathematics achievement and interest

Abstract The aim of this study was to contribute to the understanding of the effectiveness of formative assessment interventions by analysing how the quality of programme delivery affects students’ mathematics achievement and interest. Teachers (n = 17) implemented formative assessment in their ninth-grade mathematics classes and provided their students (n = 426) with written process-oriented feedback. Four feedback characteristics (number of feedback comments, specificity, feedback at self level, social reference norm) and two types of embedment of feedback in the instructional context (focus on feedback utilisation, focus on performance evaluation) were evaluated. Multilevel regression analyses revealed no significant effects of feedback characteristics on interest but negative effects of number of feedback comments and specificity on achievement in mathematics. Positive effects on mathematics achievement and interest were found when feedback was embedded in instruction and had emphasis on feedback utilisation. Students’ interest also was affected positively when performance evaluation was stressed.
High-Performance Poly-Si Thin-Film Transistor With High- $k$  ZrTiO4 Gate Dielectric

High-performance poly-Si thin-film transistors (poly-Si TFTs) with metal-induced laterally crystallized (MILC) poly-Si channel and high-k ZrTiO4 (ZTO) gate dielectric are shown for the first time. The MILC poly-Si and ZTO dielectric showed smooth interface (~1.8 nm) with a low interfacial layer and 4.1 nm of effective-oxide thickness. The electrical performance of MILC poly-Si TFT with ZTO exhibited low threshold voltage of -0.5 V, steep subthreshold slope of 0.25 V/decade, high ION/IOFF of 1.8 × 107, and high field-effect mobility of 250 cm2/Vs. These characteristics correspond to the best performance of the poly-Si TFTs with high-k gate dielectric reported so far. Moreover, the driving current and field-effect mobility of poly-Si TFT with ZTO gate dielectric were ten times higher than that of poly-Si TFT with deposited-SiO2 gate dielectric.
A multifunctional catalyst that stereoselectively assembles prodrugs

Getting phosphorus into healthy shape ProTide therapeutics play a trick on the body, getting nucleoside analogs where they need to be by decorating them with unnatural phosphoramidates in place of ordinary phosphates. These compounds pose an unusual synthetic challenge because their configuration must be controlled at phosphorus; most methods have been refined to manipulate the geometry of carbon. DiRocco et al. report a metal-free, small-molecule catalyst that attains high selectivity for nucleoside phosphoramidation by activating both reaction partners. Kinetic studies with an early prototype revealed a double role for the catalyst that inspired the rational design of a more active and selective dimeric structure. Science, this issue p. 426 A doubly activating catalyst efficiently forms key phosphorus-based chiral centers inherent to ProTide therapeutics. The catalytic stereoselective synthesis of compounds with chiral phosphorus centers remains an unsolved problem. State-of-the-art methods rely on resolution or stoichiometric chiral auxiliaries. Phosphoramidate prodrugs are a critical component of pronucleotide (ProTide) therapies used in the treatment of viral disease and cancer. Here we describe the development of a catalytic stereoselective method for the installation of phosphorus-stereogenic phosphoramidates to nucleosides through a dynamic stereoselective process. Detailed mechanistic studies and computational modeling led to the rational design of a multifunctional catalyst that enables stereoselectivity as high as 99:1.
Gatekeeping and referrals to cardiologists: General practitioners’ views on interactive communications

Abstract Objective. Referrals to specialists have not been compulsory in Iceland since 1984. In 2006, referrals were again required for patients to receive reimbursement for part of the cost of appointments with cardiologists. The aim of this study was to explore GPs’ attitudes to the referral system and possible professional gain by interactive communications. Design. Cross-sectional questionnaire survey. Setting, subjects, and main outcome measures. This is part of a larger study in 2007 on referrals from GPs to cardiologists. A questionnaire was sent to all working GPs in Iceland (n = 201 and responsible for 307 000 inhabitants) regarding the referral process, reasons for referrals, how often a response letter was received, and GPs’ attitudes to the referral system. Responses from doctors working in rural areas were compared with those working in Reykjavik and nearby urban areas. Results. The response rate was 63% (126 answers). The mean age of participants was 51; 89% were GP specialists and 60% worked in Reykjavik and nearby urban areas. Almost all respondents (98%) thought that report letters from cardiologists were helpful; 64% (95% confidence interval 53–73) thought that the recently introduced referral system did increase useful information that was beneficial to their patients. There was a statistically significant difference between colleagues working in rural areas and those working in Reykjavik and nearby urban areas regarding several aspects of the referral process. Conclusion. A referral system increases the flow of information and mutual communications between general practitioners and specialists to the benefit of the patients. The geographical location of the health care centre may be of importance regarding the value of the referrals.
Lymphocytic gastritis in pediatric celiac disease -- immunohistochemical study of the intraepithelial lymphocytic component.

BACKGROUND Lymphocytic gastritis (LG) is defined by the recognition of >25 intraepithelial lymphocytes (IEL) per 100 surface epithelial cells. Approximately 50% of children with celiac disease (CD) present LG, which mainly involves the gastric antrum and disappears after a gluten-free diet. This intraepithelial population of lymphocytes has not been immunophenotypically characterized for this age group. MATERIAL/METHODS We immunohistochemically analyzed 5 formalin-fixed, paraffin embedded biopsies of LG in children with untreated celiac disease using a panel of antibodies. All patients were diagnosed on the bases of clinical, laboratory and histopathological data. RESULTS All showed similar results. IEL proved to be CD45RO, CD3, CD7, CD8, and Tia-1 positive, while CD4, CD20, CD79a, CD56, CD57, granzyme B, perforin, TCR gamma-delta, TCR beta (V-19), CD95 (FAS), CD95-L (FAS-L) and HLA II were negative. Many IEL were in apoptosis. CD45RO, CD3 and CD7 presented as membranous staining, while Tia-1 resulted in intracytoplasmic granular brown dots. In 3 cases there were rare lymphocytes with granzyme B-positive granules localized to the lamina propria. None presented Helicobacter pylori -like organisms at the luminal surface. CONCLUSIONS LG associated with CD in children contains a peculiar CD8+ intraepithelial T-lymphocyte population which immunohistochemically lacks perforin and granzyme B, undergoes apoptosis, and is not associated with substantial damage to the epithelial cells. Our results fit with those reported in adults except for the negative results for granzyme B. The findings appear disparate from the ones described in the duodeno-jejunal mucosa in untreated celiac disease.
Anomaly detection in sea traffic - A comparison of the Gaussian Mixture Model and the Kernel Density Estimator

This paper presents a first attempt to evaluate two previously proposed methods for statistical anomaly detection in sea traffic, namely the Gaussian Mixture Model (GMM) and the adaptive Kernel Density Estimator (KDE). A novel performance measure related to anomaly detection, together with an intermediate performance measure related to normalcy modeling, are proposed and evaluated using recorded AIS data of vessel traffic and simulated anomalous trajectories. The normalcy modeling evaluation indicates that KDE more accurately captures finer details of normal data. Yet, results from anomaly detection show no significant difference between the two techniques and the performance of both is considered suboptimal. Part of the explanation is that the methods are based on a rather artificial division of data into geographical cells. The paper therefore discusses other clustering approaches based on more informed features of data and more background knowledge regarding the structure and natural classes of the data.
Improving the Reliability of Stroke Disability Grading in Clinical Trials and Clinical Practice: The Rankin Focused Assessment (RFA)

Background and Purpose— The modified Rankin Scale rates global disability after stroke and is the most comprehensive and widely used primary outcome measure in acute stroke trials. However, substantial interobserver variability in modified Rankin Scale scoring has been reported. This study sought to develop and validate a short, practicable structured assessment that would enhance interrater reliability. Methods— The Rankin Focused Assessment was developed by selecting and refining elements from prior instruments. The Rankin Focused Assessment takes 3 to 5 minutes to apply and provides clear, operationalized criteria to distinguish the 7 assignable global disability levels. The Rankin Focused Assessment was prospectively validated 3 months poststroke among 50 consecutive patients enrolled in the Phase 3 National Institutes of Health Field Administration of Stroke Therapy–Magnesium (FAST-MAG) Trial. Results— Among the 50 patients, mean age was 71.5 years (range, 43 to 93 years), 48% were female, and stroke subtype was hemorrhagic in 24%. At Day 90, 43 patients were alive and 7 had died. The modified Rankin Scale median was 2.0 and mean was 2.8. When pairs of 14 raters assessed all enrolled patients, the percent agreement was 94%, the weighted &kgr; was 0.99 (95% CI, 0.99 to 1.0), and the unweighted &kgr; was 0.93 (95% CI, 0.85 to 1.00). Among the 43 surviving patients, the percent agreement was 93%, the weighted &kgr; was 0.99 (0.98 to 1.0), and the unweighted &kgr; was 0.91 (0.82 to 1.00). Conclusions— The Rankin Focused Assessment yields high interrater reliability in the grading of final global disability among consecutive patients with stroke participating in a randomized clinical trial. The Rankin Focused Assessment is brief and practical for use in multicenter clinical trials and quality improvement activities.
Arguing Goals: An Initial Assessment of a New Measurement Instrument

This manuscript presents two studies on arguing goals. In Study 1, participants (N = 147) provided open-ended descriptions of their goals while arguing with others. A content analysis of their answers revealed 10 arguing goals: mutual understanding, problem solving, conflict resolution, persuasion, dominance, personal expression, emotional release, standing up for oneself, enjoyment, and intellectual growth. In Study 2, participants (N = 303) rated statements measuring these goals. The convergent validity, reliability, and factor structure of the measures developed were examined. Results indicated good validity and reliability, as well as unidimensional factors, with strong loadings for indicators in each scale, suggesting a promising measurement for the assessment of goals in nonserial argumentative exchanges.