Miracle-dz/UniFAR-FTUs huggingface dataset:
Doppler Color Flow Analysis of the Uterine Arteries Before and After Intrauterine Device Insertion

Objective. An intrauterine device (IUD) is one of the most frequently used methods of birth control around the world. Although a relationship between its use and menstrual disorders has been well documented, only a few studies have tried to show whether there are any vascular modifications. The aim of our study was to evaluate the influence of an IUD on uterine artery blood flow using Doppler assessment. Methods. A total of 100 patients selected for IUD use were prospectively evaluated with Doppler analysis before and 30 days after insertion. The resistive index (RI) and pulsatility index (PI) were used to evaluate uterine artery vascular resistance. Patients were allocated in 2 groups according to whether they were (group 2) or were not (group 1) lactating.Results. The PI and RI of the patients in groups 1 and 2 before and after IUD insertion were not statistically significantly different (P = .298 and .23). When we compared uterine artery blood flow indices before and after IUD insertion for groups 1 and 2 separately, we observed in group 1 that the mean ± SD PI values were 2.45 ± 0.62 and 2.55 ± 0.55 (P = .38) and the RI values were 0.87 ± 0.08 and 0.87 ± 0.06 (P = .88) before and after IUD insertion, respectively. In group 2, the PI values were 2.31 ± 0.55 and 2.37 ± 0.69 (P = .68) and the RI values were 0.85 ± 0.07 and 0.86 ± 0.07 (P = .44) before and after IUD insertion. Finally, we used the mean blood flow indices of the uterine arteries of all patients to compare the effect of IUD insertion. Results were also not statistically significant when we compared PI and RI before and after IUD insertion. Conclusions. The presence of an IUD does not interfere with the vascular resistance of the uterine arteries that can be shown by Doppler flow assessments 1 month after insertion.
Genetic variant in DIP2A gene is associated with developmental dyslexia in Chinese population

Increasing evidence suggests that there is a substantial heritable component including several risk loci and candidate genes for developmental dyslexia (DD). DIP2A has been identified to be partially deleted on chromosome region 21q22.3, which cosegregates with DD. And it fits into a theoretical molecular network of DD implicated in the development of DD. Compared with some DD candidate genes that have been extensively studied (e.g., DYX1C1, DCDC2, KIAA0319, and ROBO1), very little is known about the association between candidate gene DIP2A and DD susceptibility. And given the linguistic and genetic differences between Chinese and other Western populations, it is worthwhile validating the association of DIP2A in Chinese dyslexic children. Here, we investigated two genetic variants, selected by bioinformatics analysis, in DIP2A in a Chinese population with 409 dyslexic cases and 410 healthy controls. We observed a significantly increased DD risk associated with rs2255526 G allele (OR = 1.297, 95% CI = 1.036–1.623, Padjusted = 0.023) and GG genotypes (OR = 1.833, 95% CI = 1.043–3.223, Padjusted = 0.035), compared with their wild‐type counterparts. In addition, it was marginally significantly associated with DD under the recessive model (OR = 1.677, 95% CI = 0.967–2.908, Padjusted = 0.066) and the dominant model (OR = 1.314, 95% CI = 0.992–1.741, Padjusted = 0.057). However, we found no evidence of an association of SNP rs16979358 with DD. In conclusion, this study showed that a genetic variant in the DIP2A gene was associated with increased DD risk in China. © 2015 Wiley Periodicals, Inc.
Application of Three Dental Methods of Adult Age Estimation from Intact Single Rooted Teeth to a Peruvian Sample

Abstract: Methods of estimating adult age at death from such dental features as root translucency, root length, and the extent of periodontosis in intact single rooted teeth have proven useful in studies of modern individuals, especially in estimating age in older adults. Questions remain however, concerning the impact of regional and population variation on accuracy. To examine this issue, three approaches to age estimation were applied to a diverse sample of 100 individuals from Peru. Mean errors of estimation for all three approaches were similar to those originally reported, suggesting minimal impact of population variation of the features measured. A new regression equation, specifically for Peruvian samples, is provided.
Manipulating cellular transport and immune responses: dynamic interactions between intracellular Salmonella enterica and its host cells

Intracellular survival and replication within eukaryotic host cells is of central importance for the pathogenesis of infections caused by Salmonella enterica. Intracellular Salmonella translocates a set of effector proteins by means of a type III secretion system (T3SS) encoded by Salmonella pathogenicity island 2 (SPI2) that manipulates normal host‐cell functions. Intracellular survival and replication is linked to the function of the SPI2‐T3SS, but recent observations show that many additional cellular functions are targeted by this virulence system. In this review, we focus on the recent observations on the interference of intracellular Salmonella with functions of the innate and adaptive immune system and the modification of endocytic and exocytic cellular transport. The common molecular basis of the different SPI2‐dependent phenotypes could be the interference with cellular transport along microtubules.
Assessing analytical methods for detecting spatiotemporal interactions between species from camera trapping data

Assessing spatiotemporal interactions between species is of fundamental interest to behavioural and community ecology. Observer‐independent methods such as camera trapping facilitate the study of interactions, but analyses are hampered by the lack of comparative assessment of available approaches. We present a flexible and expandable framework to simulate and explore spatiotemporal interactions between species from camera trapping data with well‐defined properties, and compare methods to detect such interactions in a two‐species system with two types of (spatio)temporal interactions: spatiotemporal avoidance (of a site by a species after the presence of another species) and temporal segregation (shifts in daily activity patterns between species), across a range of daily activity patterns and interaction strengths. For spatiotemporal avoidance, we analysed time intervals between species records using linear models, the Mann–Whitney U‐test, a permutation test and a test based on randomly generated records. For temporal segregation, we applied a permutation test. Statistical power (the ability to detect an existing effect) for detecting spatiotemporal avoidance between species was strongly affected by interaction strength, highest for linear models and reliable above 50 records per species. Reliably detecting strong temporal segregation required fewer records (10–20 records) but depended heavily on the underlying activity pattern. All tests were valid (uniform distribution of P‐values under the null hypothesis) even at low sample sizes above a minimum of 10 records per species. Linear models were the most suitable approach to analyse spatiotemporal avoidance and can easily correct for other sources of variation in interactions. The framework presented here can help to improve survey design in camera trapping and be extended to more complex settings (e.g. with imperfect detection). In addition, it allows researchers to validate the methods used for inference of spatiotemporal interactions from camera trapping data in their specific circumstances.
Biologically inspired, self organizing communication networks

The rapid exploitation of communication networks in progressively more aspects and their associated complexity have critically driven the desire for autonomic self-organized capabilities to provide scalable adaptive, resilient and emergent behaviour to maintain their operational capability in dynamic situations. The principles of achieving autonomic capabilities are inspired from biological and ecological systems. In this paper, biological behaviour such as migration, replication and death as well as the differentiation and specialization of zygote formation are applied to the communication networks to produce an autonomic self-organizing network architecture.
Accuracy Improvements in the Orientation of ALOS PRISM Images Using IOP Estimation and UCL Kepler Platform Model

This paper presents a study that was conducted to determine the orientation of ALOS (Advanced Land Observing Satellite) PRISM (Panchromatic Remote-sensing Instrument for Stereo Mapping) triplet images, considering the estimation of interior orientation parameters (IOP) of the cameras and using the collinearity equations with the UCL (University College of London) Kepler platform model, which was adapted to use coordinates referenced to the Terrestrial Reference System ITRF97. The results of the experiments showed that the accuracies of 3D coordinates calculated using 3D photogrammetric intersection increased when the IOP were also estimated. The vertical accuracy was significantly better than the horizontal accuracy. The usability of the estimated IOP was tested to perform the bundle block adjustments of another neighbouring PRISM image triplet. The results in terms of 3D photogrammetric intersection were satisfactory and were close to those obtained in the IOP estimation experiment.
A Rule-Based Approach to Aspect Extraction from Product Reviews

Sentiment analysis is a rapidly growing research field that has attracted both academia and industry because of the challenging research problems it poses and the potential benefits it can provide in many real life applications. Aspect-based opinion mining, in particular, is one of the fundamental challenges within this research field. In this work, we aim to solve the problem of aspect extraction from product reviews by proposing a novel rule-based approach that exploits common-sense knowledge and sentence dependency trees to detect both explicit and implicit aspects. Two popular review datasets were used for evaluating the system against state-of-the-art aspect extraction techniques, obtaining higher detection accuracy for both datasets.
Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer.

PURPOSE We used a proteomics-based approach to identify tumor proteins that elicit a humoral response in breast carcinoma and that may occur as circulating antigens. EXPERIMENTAL DESIGN The breast cell line SUM-44 was used as a source of tumor cell proteins for two-dimensional PAGE (2-D PAGE) and for Western blot analysis in which individual sera were analyzed for primary antibodies. RESULTS Sera from 30 newly diagnosed patients with breast cancer were screened for IgG antibodies to tumor cell proteins. Sera from 116 patients with other cancers and from 25 healthy subjects served as controls. Restricted reactivity against a set of three proteins, identified by mass spectrometry as isoforms of a novel oncogenic protein that regulates RNA-protein interaction (designated RS/DJ-1), was observed in four patients with breast cancer, but not in healthy subjects. The identity was further confirmed by Western blotting with specific antibodies. RS/DJ-1 was found to be secreted in the breast cell line SUM-44, which led us to determine whether RS/DJ-1 was found in circulation in breast cancer. Interestingly, unlike in controls, RS/DJ-1 was readily detectable in sera from 37% of newly diagnosed patients with breast cancer. CONCLUSION The presence of autoantibodies and/or circulating RS/DJ-1 protein in sera from patients with breast cancer may have clinical utility.
Gastrointestinal Stromal Tumours: An Update

Purpose. To study the evolution of concepts concerning gastrointestinal stromal tumours (GISTs) over 30 years. Discussion. GISTs have been, for more than 30 years, the subject of considerable controversy regarding their line of differentiation as well as the prediction of their behaviour. Furthermore, once they spread within the peritoneal cavity, they are extremely hard to control. The recent findings of c-Kit mutations and the immunohistochemical detection of the product of this gene, KIT or CD117, in the mainly non-myogenic subset of this family of tumours, has led to a reappraisal of this group of lesions, which, with some exceptions, is now thought to be derived from the interstitial cells of Cajal, and this has facilitated a clearer definition of their pathological spectrum. In this article, we review chronologically the evolution of the concept of GIST with the gradual application of electron microscopy, immunohistochemistry, DNA ploidy analysis. We discuss the impact of these techniques on the pathological assessment and clinical management of GISTs.
Case of postural complex sleep apnea: Effect of gravitational forces

We report a case of an elderly male with predominant obstructive sleep apnea and who developed or complex sleep apnea (CxSA) at the start of continuous positive airway pressure (CPAP) titration. This CxSA was more prominent in supine position, and he was not settling with either CPAP/bilevel positive airway pressure (PAP) in supine position. He finally settled with CPAP along with position therapy. This case highlights the importance of treating CxSA with basic PAP modes like CPAP along with positional therapy before switching to costlier therapies such as adaptive servo-ventilation.
Managing high blood pressure during acute ischemic stroke and intracerebral hemorrhage

Purpose of review Blood pressure (BP) elevations above premorbid levels are observed in at least 60% of acute ischemic and hemorrhagic stroke patients, within the first 24 h of symptom onset. A number of potential causes have been hypothesized, and high BP may be associated with poor stroke outcome. This review discusses management strategies of high BP in acute stroke, in the context of current guidelines. Recent findings Excessive BP elevation can impact acute stroke therapeutic strategies, particularly in modifying intervention safety and efficacy. Currently, guidance on BP management in acute ischemic stroke and intracerebral hemorrhage (ICH) exists in a limited number of specific clinical presentations, including spontaneous ICH and continuing versus stopping preexisting antihypertensive therapy. However, ongoing clinical trials will further investigate the safety and efficacy of urgent BP-lowering therapy for other indications. Summary There are clear national and international guidelines on BP lowering for specific indications, as well as ongoing clinical trials aiming to address common clinical scenarios in which the evidence-base is lacking and uncertain. This is specifically in important stroke subgroups previously excluded from trials, patients requiring mechanical thrombectomy and nonvitamin K antagonist-associated ICH reversal.
Minimum Wages and Employment: A Case Study of the Fast Food Industry in New Jersey and Pennsylvania

On April 1, 1992 New Jersey's minimum wage increased from $4.25 to $5.05 per hour. To evaluate the impact of the law we surveyed 410 fast food restaurants in New Jersey and Pennsylvania before and after the rise in the minimum. Comparisons of the changes in wages, employment, and prices at stores in New Jersey relative to stores in Pennsylvania (where the minimum wage remained fixed at $4.25 per hour) yield simple estimates of the effect of the higher minimum wage. Our empirical findings challenge the prediction that a rise in the minimum reduces employment. Relative to stores in Pennsylvania, fast food restaurants in New Jersey increased employment by 13 percent. We also compare employment growth at stores in New Jersey that were initially paying high wages (and were unaffected by the new law) to employment changes at lower-wage stores. Stores that were unaffected by the minimum wage had the same employment growth as stores in Pennsylvania, while stores that had to increase their wages increased their employment.
Trait Impulsivity Is Associated with the Risk of Falls in Parkinson’s Disease

Objective Impulsivity is a “tendency to act prematurely without foresight. ” Clinical experience suggests that such impulsive behavior can impact on the fall risk in Parkinson’s disease (PD), but this has never been tested. We investigated whether trait impulsivity is related to fall risk in a large cohort of PD patients. We also investigated whether trait impulsivity affects the fall risk differently for patients with more or less postural instability and gait disability (PIGD). Methods 388 patients with PD (H&Y≤3) completed the Barratt Impulsiveness Scale (BIS-11, higher scores indicating greater impulsivity) to assess trait impulsivity, including three subscales: motor impulsivity (e.g. “I do things without thinking”), attentional impulsivity (e.g. “I concentrate easily”) and non-planning (e.g. “I plan tasks carefully”). Falls were registered prospectively for 6 months. Patients classified as non-fallers (0 falls, n = 237) were compared to recurrent PD fallers (>1 fall, n = 78). Results Total impulsivity scores were higher for recurrent fallers (59.5) compared to non-fallers (56.8; p = .012). This effect was predominantly driven by higher scores on the subscale for attentional impulsivity (p = .003). The difference in attentional impulsivity was independent of gender, disease severity, dopaminergic medication, and cognitive function. Motor and non-planning impulsivity did not differ between recurrent fallers and non-fallers. There was no evidence that impulsivity modulated the association between PIGD and fall risk. Discussion This is the first evidence that impulsivity, in particular in the attentional domain, is related to fall risk in PD.
Collaborative Strategic Board Games as a Site for Distributed Computational Thinking

ABStrAct This paper examines the idea that contemporary strategic board games represent an informal, interactional context in which complex computational thinking takes place. When games are collaborative – that is, a game requires that players work in joint pursuit of a shared goal – the computational thinking is easily observed as distributed across several participants. This raises the possibility that a focus on such board games are profitable for those who wish to understand computational thinking and learning in situ. This paper intro-duces a coding scheme, applies it to the recorded discourse of three groups of game players, and provides qualitative examples of computational thinking that are observed and documented in Pandemic. The primary contributions of this work are the description of and evidence that complex computational thinking can develop spontaneously during board game play. Steinkuehler, 2006). Often, these benefits are associated with video games and other highly interactive computational media. It is largely thought that the ability to foster a sense of im-mersion is a genuine strength of video games that distinguishes them from many other learning contexts (Shelton & Wiley, 2007). Still, there are reasons to suspect that some of the generative potential of games is not re-stricted to those that take place on a computer platform. At their most base level, games are systems of rules in which players operate on representations. In a computer game, those rules are generally executed and strictly enforced by
3D DVH-based metric analysis versus per-beam planar analysis in IMRT pretreatment verification.

PURPOSE To evaluate methods of pretreatment IMRT analysis, using real measurements performed with a commercial 2D detector array, for clinical relevance and accuracy by comparing clinical DVH parameters. METHODS We divided the work into two parts. The first part consisted of six in-phantom tests aimed to study the sensitivity of the different analysis methods. Beam fluences, 3D dose distribution, and DVH of an unaltered original plan were compared to those of the delivered plan, in which an error had been intentionally introduced. The second part consisted of comparing gamma analysis with DVH metrics for 17 patient plans from various sites. Beam fluences were measured with the MapCHECK 2 detector, per-beam planar analysis was performed with the MapCHECK software, and 3D gamma analysis and the DVH evaluation were performed using 3DVH software. RESULTS In a per-beam gamma analysis some of the tests yielded false positives or false negatives. However, the 3DVH software correctly described the DVH of the plan which included the error. The measured DVH from the plan with controlled error agreed with the planned DVH within 2% dose or 2% volume. We also found that a gamma criterion of 3%∕3 mm was too lax to detect some of the forced errors. Global analysis masked some problems, while local analysis magnified irrelevant errors at low doses. Small hotspots were missed for all metrics due to the spatial resolution of the detector panel. DVH analysis for patient plans revealed small differences between treatment plan calculations and 3DVH results, with the exception of very small volume structures such as the eyes and the lenses. Target coverage (D(98) and D(95)) of the measured plan was systematically lower than that predicted by the treatment planning system, while other DVH characteristics varied depending on the parameter and organ. CONCLUSIONS We found no correlation between the gamma index and the clinical impact of a discrepancy for any of the gamma index evaluation possibilities (global, local, 2D, or 3D). Some of the tests yielded false positives or false negatives in a per-beam gamma analysis. However, they were correctly accounted for in a DVH analysis. We also showed that 3DVH software is reliable for our tests, and is a viable method for correlating planar discrepancies with clinical relevance by comparing the measured DVH of target and OAR's with clinical tolerance.
Cockroaches breathe discontinuously to reduce respiratory water loss

SUMMARY The reasons why many insects breathe discontinuously at rest are poorly understood and hotly debated. Three adaptive hypotheses attempt to explain the significance of these discontinuous gas exchange cycles (DGCs), whether it be to save water, to facilitate gas exchange in underground environments or to limit oxidative damage. Comparative studies favour the water saving hypothesis and mechanistic studies are equivocal but no study has examined the acclimation responses of adult insects chronically exposed to a range of respiratory environments. The present research is the first manipulative study of such chronic exposure to take a strong-inference approach to evaluating the competing hypotheses according to the explicit predictions stemming from them. Adult cockroaches (Nauphoeta cinerea) were chronically exposed to various treatments of different respiratory gas compositions (O2, CO2 and humidity) and the DGC responses were interpreted in light of the a priori predictions stemming from the competing hypotheses. Rates of mass loss during respirometry were also measured for animals acclimated to a range of humidity conditions. The results refute the hypotheses of oxidative damage and underground gas exchange, and provide evidence supporting the hypothesis that DGCs serve to reduce respiratory water loss: cockroaches exposed to low humidity conditions exchange respiratory gases for shorter durations during each DGC and showed lower rates of body mass loss during respirometry than cockroaches exposed to high humidity conditions.