Miracle-dz/UniFAR-FTUs huggingface dataset:
How Should Complementary Practitioners and Physicians Communicate? A Cross-Sectional Study from Israel

Objectives: The extensive use of complementary and alternative medicine for patients can complicate dialogue between physicians and complementary and alternative medicine practitioners, but not much data have been collected on the expectations and attitudes of physicians and complementary and alternative medicine practitioners concerning their communication and collaboration. In this study, we compared the results of a cross-sectional survey of both groups to elucidate the attitudes and expectations regarding communication and collaboration. Methods: Questionnaires were mailed electronically or through the mail to 2532 primary care physicians and 450 complementary and alternative medicine practitioners employed by Clalit Health Services, the largest health maintenance organization in Israel. Results: Questionnaires were returned by 333 physicians (response rate of 13%) and 241 practitioners (response rate of 54%). According to our results, the majority of both groups expressed an interest in clinical practice collaboration (69% and 77% of physicians and practitioners, respectively; P = .043); preferred using a medical letter to communicate with each other; and expected to consult with each other about mutual patients to formulate treatment plans. However, the practitioners were more interested than the physicians in collaborative scientific research (15% vs 42%, respectively; P < .0001) and collaborative medical education (2% vs 27%, respectively; P < .0001). The physicians also supported a physician-guided model of teamwork in clinical practice, whereas the practitioners supported a more collaborative model. Conclusions: Educational programs for primary care physicians and complementary and alternative medicine practitioners should focus on aspects of communication between the groups and practical methods for writing referral or medical letters.
Prospective Coding for Objects in Primate Prefrontal Cortex

We examined neural activity in prefrontal (PF) cortex of monkeys performing a delayed paired associate task. Monkeys were cued with a sample object. Then, after a delay, a test object was presented. If the test object was the object associated with the sample during training (i.e., its target), they had to release a lever. Monkeys could bridge the delay by remembering the sample (a sensory-related code) and/or thinking ahead to the expected target (a prospective code). Examination of the monkeys’ behavior suggested that they were relying on a prospective code. During and shortly after sample presentation, neural activity in the lateral PF cortex primarily reflected the sample. Toward the end of the delay, however, PF activity began to reflect the anticipated target, which indicated a prospective code. These results provide further confirmation that PF cortex does not simply buffer incoming visual inputs, but instead selectively processes information relevant to current behavioral demands, even when this information must be recalled from long-term memory.
Friendship standards: The dimensions of ideal expectations

This multi-study investigation identified and confirmed the factor structure of ideal friendship standards. Study 1 (N = 307) conducted an exploratory factor analysis on 30 existing subscales of friendship expectations. Study 2 (N = 401) reduced 181 items from past subscales and single-item measures of friendship expectations to 51 items measuring six factors. Study 3 (N = 668) used an international internet sample to conduct a confirmatory factor analysis on the six factor model. Samples from studies 2 and 3 were combined and factorial invariance was demonstrated by sample, by participant sex, and by age. The six factors of expectations (i.e., symmetrical reciprocity, agency, enjoyment, instrumental aid, similarity, and communion) constitute the ideal standards of friendship.
Preoccipital cortex receives a differential input from the frontal eye field and projects to the pretectal olivary nucleus and other visuomotor-related structures in the rhesus monkey

Abstract The bidirectional axonal transport capabilities of the horseradish peroxidase (HRP) technique facilitated the study of the frontal-eye-field (FEF) input and pretectal output of two regions of extrastriate preoccipital cortex (POC). Following horseradish peroxidase (HRP) gel implants into the middle and dorsal POC in two rhesus monkeys, the middle POC implant demonstrated retrograde frontal cortical labeling largely restricted to the inferior frontal eye field (iFEF) and adjacent inferior prefrontal convexity, whereas the dorsal POC implant showed labeling in the caudal ventral bank of the superior ramus of the arcuate sulcus (sas) and middle-to-dorsal region of the rostral bank of the concavity of the arcuate sulcus (dorsal FEF). Prominent anterogradely labeled efferent preoccipital projections were observed to the ipsilateral pretectal olivary nucleus (PON) and to a lesser extent the anterior pretectal nucleus. Although the middle POC case had heavier projections to the lateral PON, the dorsal case projected more heavily to the medial PON. In addition, both implants demonstrated subcortical connections with the lateral and dorsal inferior pulvinar nuclei, central superior lateral thalamic intralaminar nucleus, caudate nucleus, and middle-to-ventral claustrum. However, while the middle POC implant had efferent projections to the superficial superior colliculus (SC), pregeniculate nucleus (PGN), lateral terminal accessory optic nucleus (LTN), and dorsolateral pontine nucleus (DLPN), resembling those previously reported for the middle temporal (MT) visual area (Maunsell & Van Essen, 1982; Ungerleider et al., 1984), the dorsal implant had projections to the lateral intermediate SC, zona incerta (ZI), PGN, a notably lesser projection to the LTN, and basilar pontine projections to the lateral and lateral dorsal pontine subnuclei (not including the extreme dorsolateral DLPN). These preliminary results suggest that the preoccipital cortex, which reportedly functions in pupillary constriction, accommodation, and convergence, entertains connections with the PON and other visuomotorrelated structures, and thus could act as an intermediary in the pathway between the iFEF and PON, and provide a possible explanation for pupillary effects that occur with stimulation of the FEF (Jampel, 1960) and within the context of other oculomotor activities. The findings shed light on certain differences in connections of middle vs. dorsal POC with visuomotor-related nuclei, and appear to suggest that the middle region, which receives input from the iFEF, has greater access to the optokinetic (OKN) system by virtue of its projection to the LTN, and to the smooth-pursuit system by virtue of its projection to the DLPN.
X-Linked Inhibitor of Apoptosis Protein Expression and the Regulation of Apoptosis During Human Placental Development1

Abstract In this study, we have examined the expression and potential role of X-linked inhibitor of apoptosis protein (XIAP), Fas, and Fas ligand (FasL) in the regulation of apoptosis throughout placental development. Protein expression was determined by Western blot analysis and immunohistochemistry, whereas apoptotic cell death was assessed by DNA fragmentation analysis and TUNEL. The XIAP was present in trophoblast throughout placental development, but its content significantly decreased during late pregnancy, when apoptosis was maximal. The FasL content was low during early placental development but increased coincidentally to the decrease in XIAP during the third trimester. Our data also suggest that placental apoptosis is the culmination of the relative expression of these cell-death and -survival proteins, a phenomenon that is cell type-specific and dependent on cytodifferentiation and the stage of placental development. Moreover, the induction of syncytiotrophoblast apoptosis may involve the concomitant up-regulation of FasL for Fas activation and the removal of downstream inhibition of the apoptotic cascade by XIAP.
The historic hotel as ‘quasi-freedom machine’: negotiating utopian visions and dark histories at Amsterdam's Lloyd Hotel and ‘Cultural Embassy’

Existing research on historic hotels has identified their role as key projections of community ideals and place identities, as ‘hip’/creative business ventures and as dark tourism sites of ‘darkness', difficulties and dissonances. However, there has been less discussion on what happens when these intentions and operations come together in a single historic hotel. Specifically, we argue that the historical Lloyd Hotel in Amsterdam was recently adapted to function as a ‘quasi-freedom machine’ for cultural and heritage guests and visitors – a building to be unchained materially from its carceral pasts via extensive conservation and to become a liberating space for cultural, heritage and hospitality users. Drawing on the narratives proposed by the architects and managers adapting the building and the accounts of its former (juvenile detention centre worker) and current users (hotel guests and cultural tourists), this paper examines the convergences and divergences related to the creation of such a single ‘utopian’ space, also in relation to its painful past and cultural touristic present. In doing so, the article intends to contribute to the understanding of the relationship between utopian (liberating) visions of and user practices in historic hotels marked by difficult histories.
The Factors Related to CD4+ T-Cell Recovery and Viral Suppression in Patients Who Have Low CD4+ T Cell Counts at the Initiation of HAART: A Retrospective Study of the National HIV Treatment Sub-Database of Zhejiang Province, China, 2014

Background Since China has a unique system of delivering HIV care that includes all patients’ records. The factors related to CD4+ T-cell recovery and viral suppression in patients who have low CD4+ T cell counts at the initiation of HAART are understudied in the China despite subsequent virological suppression (viral load < 50 copies/mL) is unknown. Methods The authors conducted a retrospective cohort study using data from the national HIV treatment sub-database of Zhejiang province to identify records of HIV+ patients. Patient records were included if they were ≥ 16 years of age, had an initial CD4 count < 100 cells/μL, were on continuous HAART for at least one year by the end of December 31, 2014; and achieved and maintained continued maximum virological suppression (MVS) (< 50 copies/ml) by 9 months after starting HAART. The primary endpoint for analysis was time to first CD4+ T cell count recovery (≥ 200, 350, 500 cells/μL). Cox proportional hazard regression was used to identify the risk factors for CD4+ T cell count recovery to key thresholds (200–350, 350–500, ≥ 500 cells/μL) by the time of last clinical follow-up (whichever occurred first), key thresholds (follow-up date for analysis), with patients still unable to reach the endpoints being censored by the end December 31, 2014 (follow-up date for analysis). Results Of the 918 patients who were included in the study, and the median CD4+ T cell count was 39 cells/μL at the baseline. At the end of follow-up, 727 (79.2%), 363 (39.5%) and 149 (16.2%) patients had return to ≥ 200, 350, and 500 cells/μL, respectively. Kaplan-Meier analysis demonstrated that the rate of patients with CD4+ count recovery to ≥ 200, 350, and 500 cells/μL after 1 year on HAART was 43.6, 8.6, and 2.5%, respectively, after 3 years on treatment was 90.8, 46.3, and 17.9%, respectively, and after 5 years on HAART was 97.1, 72.2, and 36.4%, respectively. The median time to return to 200–350, 350–500, ≥ 500cells/μL was 1.11, 3.33 and 6.91 years, respectively. Factors of age (aHR = 0.77, 95%CI 0.61–0.97), baseline CD4+ count (aHR = 1.60, 95%CI 1.37–1.86), initial regimens, changes in regimen (aHR = 0.58, 95%CI 0.49–0.69), and inclusion of a cotrimoxazole prophylaxis (aHR = 0.66, 95%CI 0.51–0.85) were associated with CD4+ T cell count recovery. Conclusion The proportion of patients with initially low CD4 counts after nine months of treatment and that achieved continuous virological suppression was greater than 70% for persons with CD4+ count ≥ 350. Conversely, only 35% of patients recovered to levels of 500 cells/μL after 5 years of treatment, and levels continued to rise significantly with further long-term HAART. Early HAART intervention will be necessary for achieving effective CD4+ T cell responses and optimal immunological function in HIV+ patients.
Should relationship quality be measured as a disaggregated or a composite construct

Purpose - – The purpose of this paper is to report the results of an empirical study that tested two competing models of relationship quality for superiority and further examined the effect of relationship quality antecedents as well as relationship quality constructs on customer loyalty. Design/methodology/approach - – Quantitative cross-sectional data generated from 332 informants who are experienced users of banking services formed the final database. The construct validity and reliability of the data set was confirmed. The two competing models were tested with partial least squares structural equation modelling technique. Findings - – Although the two competing models support all the hypothesised relationships as expected, the disaggregated model of relationship quality was found to be a better predictor of customer loyalty than the composite model of the construct. The two models also show that relationship quality does transmit the effect of customer orientation, expertise and information sharing to customer loyalty. But each of these determinants contributed differentially to relationship quality in both models just as trust and satisfaction contributed differentially to customer loyalty in the disaggregated model. Research limitations/implications - – This paper questions the predictive ability of all previous models that tested relationship quality as a composite construct. The concern is that outputs from those studies may not have reflected the accurate explanation of the construct on companies’ bottom line. Future research integrating the construct into behavioural models should, therefore, examine the construct from a disaggregated viewpoint. Practical implications - – Retail managers especially those within the banking sector are better placed to enhance customer loyalty when relationship quality implementation is initiated from the lens of both trust and satisfaction as separate and interdependent constructs, rather than a composite measure. Such approach widens the latitude to identify areas where attention to improvement is needed most. Originality/value - – The uniqueness of this paper is the measurement of relationship quality both as a disaggregated and composite construct in one study. As far as could be established, in exception of Rafiq
All shapes busy list contiguous allocation strategy for 3D mesh multicomputers

Although contiguous allocation is known to suffer from high processor fragmentation, it is useful for security and accounting reasons. This is because the allocated jobs are isolated from one another, where each job is allocated to an exclusive submesh of processors, and the allocated sub-mesh has the same size and shape of the requested job. The size and shape constraint leads to high processor fragmentation. Most recent contiguous allocation strategies suggested for 3D mesh multiconputers attemp all possible rotations of the job request when allocation fails for the original job request, which reduces processor fragmentation and hence improves system performance. To generalize this restricted rotation, we propose in this paper a new contiguous allocation strategy for 3D mesh multicomputers, referred to as All Shapes Busy List (ASBL for short), which considers all possible contiguous request shapes when attempting allocation for a job request. ASBL depends on the list of allocated sub-meshes in the method used for selecting an allocation submesh. Results from extensive simulations under a variety of system loads confirm that the ASBL strategy improves system performance in terms of parameters such as the average turnaround times and system utilization.
Adult Learning Theory & Leadership Development

This article addresses the natural, yet overlooked link between leadership development and adult learning theory. The article begins with a summary of four adult learning theories: Behaviorism, Cognitivism, Social Learning Theory and Constructivism. Each theory is described and its potential application to leadership development is discussed. The article concludes with a discussion of Jay Conger's four categories of leadership development programming and their link to theories of adult learning.
Polyketide Synthases in the Microbiome of the Marine Sponge Plakortis halichondrioides: A Metagenomic Update

Sponge-associated microorganisms are able to assemble the complex machinery for the production of secondary metabolites such as polyketides, the most important class of marine natural products from a drug discovery perspective. A comprehensive overview of polyketide biosynthetic genes of the sponge Plakortis halichondrioides and its symbionts was obtained in the present study by massively parallel 454 pyrosequencing of complex and heterogeneous PCR (Polymerase Chain Reaction) products amplified from the metagenomic DNA of a specimen of P. halichondrioides collected in the Caribbean Sea. This was accompanied by a survey of the bacterial diversity within the sponge. In line with previous studies, sequences belonging to supA and swfA, two widespread sponge-specific groups of polyketide synthase (PKS) genes were dominant. While they have been previously reported as belonging to Poribacteria (a novel bacterial phylum found exclusively in sponges), re-examination of current genomic sequencing data showed supA and swfA not to be present in the poribacterial genome. Several non-supA, non-swfA type-I PKS fragments were also identified. A significant portion of these fragments resembled type-I PKSs from protists, suggesting that bacteria may not be the only source of polyketides from P. halichondrioides, and that protistan PKSs should receive further investigation as a source of novel polyketides.
Evaluation of Cognitive-Behavioral Programs for Offenders: A Look at Outcome and Responsivity in Five Treatment Programs

______________ This research was made possible with a grant from the Ohio Office of Criminal Justice Services. Grants number 1999-DG-G02-0068. Views expressed are those of the authors and do not necessarily reflect the views of OCJS. Acknowledgements This report would not have been possible without the cooperation and support of a number of individuals. We would like to thank everyone involved in the project for their time and effort. In particular, we would like to thank the following: Thank you for all of your help.
Distribution of ESBLs among Escherichia coli isolates from outpatients with recurrent UTIs and their antimicrobial resistance.

INTRODUCTION Extended-spectrum β-lactamase (ESBL)-producing strains of Enterobacteriaceae are considered to be emerging pathogens. They are a major problem in hospitalized as well as community-based patients. Major outbreaks involving ESBL strains have been reported from all over the world. Recurrent urinary tract infection (UTI) is one of the risk factors for infection with ESBL-producing E. coli in hospitalized and non-hospitalized patients. METHODOLOGY Ninety-one E. coli isolates from outpatients with recurrent UTIs were surveyed phenotypically and genotypically for ESBL production and tested for antimicrobial susceptibility. RESULTS Of 91 E. coli isolates, 75.8% were resistant to each of cefotaxime and ceftazidime and 74.7% produced ESBLs. CTX-M-type was the most frequent ESBL (accounting for 70.3%), with CTX-M-1 being the only subtype possessed by these isolates. The prevalence of OXA- and SHV-type was 32.9% and 10.9%, respectively. None of the isolates produced TEM β-lactamase. All OXA-type ESBL were produced concomitantly with CTX-M1. Both ESBL producers and non-producers had high resistance to ampicillin followed by trimethoprim-sulphamethoxazole, third-generation cephalosporins, and tetracycline. No isolate showed resistance to imipenem and meropenem. In total, resistance rates of ESBL producers were higher than those of ESBL non-producers, as was multidrug resistance (52.7% versus 8.7%, respectively). CONCLUSIONS Our study documented high distribution of ESBLs among E. coli isolates from outpatients with recurrent UTIs, with CTX-M as the predominant ESBL. In the current situation, it is important that antibiotic treatment is be started only after a proper sensitivity report is obtained from the laboratory.
2007 Wallace Foundation Distinguished Lecture—What Makes Education Research “Educational”?

Education research is plagued by skeptics who doubt its quality and relevance. Inhabitants of schools of education have been among the sharpest critics, and internal battles rage over method and rigor. Yet often lacking is research that explains causes or examines the interplay at the heart of educational practice and policy. This article argues for a conception of research in education that deliberately presses into what is called here the instructional dynamic. Using a sample of studies that exemplify this quintessentially educational perspective, the authors unpack key features of research that probes inside education. They discuss how such research complements in essential ways the other kinds of scholarship that examine and inform education.
The pharmacokinetics, pharmacodynamics, clinical efficacy, safety and tolerability of linaclotide

Introduction: Linaclotide is a novel intestinal secretagogue that is in the advanced stages of development for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic constipation. These functional gastrointestinal disorders are highly prevalent in adults and children and often do not respond satisfactorily to available treatments. Linaclotide appears to be a promising new agent for patients who are not satisfied with currently available agents. Areas covered: This article is formed from a literature review of all the studies published about linaclotide up to January 2011. It covers the pharmacodynamics and pharmacokinetics of this novel agent. It also provides a summary of the published clinical trials concerning efficacy and safety in patients with chronic constipation and IBS-C. The authors provide the reader with a better understanding of how the molecular pathophysiology of certain enteropathic diarrheal bacteria lead to the development of this novel prosecretory drug. The reader will also learn about the development of molecularly-based treatment options for chronic constipation and other constipation-associated disorders such as IBS-C. Expert opinion: Linaclotide appears to be a well-tolerated and effective agent for many patients with chronic constipation and IBS-C. Two Phase III studies in chronic constipation and two in IBS-C have provided promising data on the efficacy and safety of this agent for these two disorders. The positioning of linaclotide among the various available agents for these two disorders remains to be established after approval from the FDA is granted.