Miracle-dz/UniFAR-FTUs huggingface dataset:
PV+ Cells Enhance Temporal Population Codes but not Stimulus-Related Timing in Auditory Cortex

Spatio-temporal cortical activity patterns relative to both peripheral input and local network activity carry information about stimulus identity and context. GABAergic interneurons are reported to regulate spiking at millisecond precision in response to sensory stimulation and during gamma oscillations; their role in regulating spike timing during induced network bursts is unclear. We investigated this issue in murine auditory thalamo-cortical (TC) brain slices, in which TC afferents induced network bursts similar to previous reports in vivo. Spike timing relative to TC afferent stimulation during bursts was poor in pyramidal cells and SOM+ interneurons. It was more precise in PV+ interneurons, consistent with their reported contribution to spiking precision in pyramidal cells. Optogenetic suppression of PV+ cells unexpectedly improved afferent-locked spike timing in pyramidal cells. In contrast, our evidence suggests that PV+ cells do regulate the spatio-temporal spike pattern of pyramidal cells during network bursts, whose organization is suited to ensemble coding of stimulus information. Simulations showed that suppressing PV+ cells reduces the capacity of pyramidal cell networks to produce discriminable spike patterns. By dissociating temporal precision with respect to a stimulus versus internal cortical activity, we identified a novel role for GABAergic cells in regulating information processing in cortical networks.
11 C-choline vs . 18 F-FDG PET / CT in assessing bone involvement in patients with multiple myeloma

Background: Multiple Myeloma (MM) is a B cell neoplasm causing lytic or osteopenic bone abnormalities. Whole body skeletal survey (WBSS), Magnetic resonance (MR) and 18F-FDG PET/CT are imaging techniques routinely used for the evaluation of bone involvement in MM patients. Aim: As MM bone lesions may present low 18F-FDG uptake; the aim of this study was to assess the possible added value and limitations of 11C-Choline to that of 18F-FDG PET/CT in patients affected with MM. Methods: Ten patients affected with MM underwent a standard 11C-Choline PET/CT and an 18F-FDG PET/CT within one week. The results of the two scans were compared in terms of number, sites and SUVmax of lesions. Results: Four patients (40%) had a negative concordant 11C-Choline and 18F-FDG PET/CT scans. Two patients (20%) had a positive 11C-Choline and 18F-FDG PET/CT scans that identified the same number and sites of bone lesions. The remaining four patients (40%) had a positive 11C-Choline and 18F-FDG PET/CT scan, but the two exams identified different number of lesions. Choline showed a mean SUVmax of 5 while FDG showed a mean SUVmax of 3.8 (P = 0.042). Overall, 11C-Choline PET/CT scans detected 37 bone lesions and 18F-FDG PET/CT scans detected 22 bone lesions but the difference was not significant (P = 0.8). Conclusion: According to these preliminary data, 11C-Choline PET/CT appears to be more sensitive than 18FFDG PET/CT for the detection of bony myelomatous lesions. If these data are confirmed in larger series of patients, 11C-Choline may be considered a more appropriate functional imaging in association with MRI for MM bone staging. Published: 20 June 2007 World Journal of Surgical Oncology 2007, 5:68 doi:10.1186/1477-7819-5-68 Received: 9 February 2007 Accepted: 20 June 2007 This article is available from: http://www.wjso. com/content/5/1/68 © 2007 Nanni et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The differential effects of MDMA (ecstasy) use on executive and memory processes

The purpose of this thesis was to examine the nature of executive function deficits in ecstasy users, and the contribution of these executive functions to performance on other cognitive tasks. Using recent theoretical models of executive functioning recreational ecstasy-polydrug users were tested in laboratory settings on measures of mental set switching, response inhibition, memory updating and access to semantic memory. It was found that ecstasy users performed significantly worse than nonusers on measures of updating and access, although cocaine also emerged as an important factor in deficits in access. The contribution of access and updating to performance on more complex executive function tasks was then assessedI.t was found that while associative learning is relatively independent of access and updating, the same was not true for everyday memory and syllogistic reasoning. Ecstasy group related deficits in syllogistic reasoning were slightly attenuated following control for access and substantially following control for updating. It emerged that everyday memory deficits were more related to the use of cannabis than the use of ecstasy. The results of this thesis have serious implications for those who use ecstasy and should be used in educating such individuals. Outside the area of Psychopharmacology this thesis provides further support for the nature of executive functions and their relationship with syllogistic reasoning and everyday memory. Future research should assess executive functions along the same paradigm and seek to recruit polydrug control groups.
Fast block type decision algorithm for intra prediction in H.264 FRext

This paper presents a fast block type decision algorithm for 4/spl times/4, 8/spl times/8 and 16/spl times/16 intra prediction in H.264/AVC FRExt (fidelity range extension). With additional 8/spl times/8 intra prediction size, the complexity of intra prediction is increased by almost 50%. Thus, the proposed algorithm uses the smoothness of the macroblock to select the intra prediction block size and save computational cost. When further combining with our previously proposed three-step fast intra prediction algorithm, the proposed algorithm can save up to 32.1% and 63.4% of computation time of all I frames and intra prediction coding respectively, and achieves average 1.05% bit rate decrease and 0.046 dB quality degradation when comparing with the reference software.
Effects of Glucagon-Like Peptide-1 Receptor Agonists on Weight Loss in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis

To evaluate the effectiveness of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on weight reduction in patients with Type 2 diabetes mellitus (Type 2 DM), a network meta-analysis was conducted. MEDLINE, EMBASE, Cochrane Library, and ClinicalTrials.gov were searched from 1950 to October 2013. Randomized controlled trials (RCTs) involving GLP-1 RAs were included if they provided information on body weight. A total of 51 RCTs were included and 17521 participants were enrolled. The mean duration of 51 RCTs was 31 weeks. Exenatide 10 μg twice daily (EX10BID) reduced weight compared with exenatide 5 μg twice daily (EX5BID), liraglutide 0.6 mg once daily (LIR0.6QD), liraglutide—1.2 mg once daily (LIR1.2QD), and placebo treatment, with mean differences of −1.07 kg (95% CI: −2.41, −0.02), −2.38 kg (95% CI: −3.71, −1.06), −1.62 kg (95% CI: −2.79, −0.43), and −1.92 kg (95% CI: −2.61, −1.24), respectively. Reductions of weight treated with liraglutide—1.8 mg once daily (LIR1.8QD) reach statistical significance (−1.43 kg (95% CI: −2.73, −0.15)) versus LIR1.2QD and (−0.98 kg (95% CI: −1.94, −0.02)) versus placebo. Network meta-analysis found that EX10BID, LIR1.8QD, and EX2QW obtained a higher proportion of patients with weight loss than other traditional hypoglycemic agents. Our results suggest GLP-1 RAs are promising candidates for weight control in comparison with traditional hypoglycemic drugs, and EX10BID, LIR1.8QD, and EX2QW rank the top three drugs.
Changes in erythropoiesis-stimulating agent (ESA) dosing and haemoglobin levels in US non-dialysis chronic kidney disease patients between 2005 and 2009.

BACKGROUND Recent clinical trials in cancer patients treated with erythropoiesis-stimulating agents (ESAs) and in CKD patients treated to haemoglobin (Hb) targets above the labeled range of 10-12 g/dL with ESAs raised safety concerns regarding ESA therapy. Subsequently, product labeling was revised including addition of a black-box warning and removal of many quality of life claims not supported by current standards, and there were changes in reimbursement and anaemia guidelines. The extent to which these events influenced ESA dosing and Hb levels in patients with chronic kidney disease not on dialysis (CKD-NOD) is not known. METHODS We used data collected in a series of cross-sectional surveys between March 2005 and July 2009. Patients with CKD-NOD were selected from a random sample of free-standing US nephrology clinics. Information on demographics, insurance information, laboratory data and ESA use was abstracted from medical records by site investigators. We evaluated ESA treatment (use and dosing) and Hb levels over time and used multivariate linear regression to assess changes in ESA doses and Hb levels over time adjusting for case-mix differences. RESULTS Between 2005 and 2009, 15 836 CKD-NOD patients were sampled. During this period, ESA use declined from 60 to 46%, and the mean dose declined from 176 to 136 mcg/month; the largest decline in use and in dose occurred beginning in 2007. Simultaneously, the mean (standard deviation) Hb level in ESA-treated patients declined from 11.5 (1.4) to 10.6 (1.2) g/dL, though the decline was most pronounced starting in 2007. As the mean Hb declined, the percent of treated patients with an Hb > 12 g/dL dropped from 27 to 12%, and the mean dose in this sub-population declined from 173 to 111 mcg/month. CONCLUSION The emergence of safety concerns and the subsequent changes in product labeling, reimbursement and clinical practice guidelines all appear to have influenced physician dosing practices resulting in less frequent use of ESAs, lower ESA doses and lower achieved Hb levels in CKD-NOD patients.
The relaxation effects of stimulative and sedative music on mathematics anxiety: A perception to physiology model

Previous research on music and mathematics anxiety has relied primarily on self-reports without biological measurements. To address whether these parameters were correlated, we included blood pressure physiological measures, the State-Trait Anxiety Inventory (STAI) and the Mathematics Anxiety Rating Scale (MARS) in our study. One hundred and five psychology undergraduates were assigned to sedative, stimulative and “no music” conditions while completing Cambridge GCE O Level mathematical questions. Anxiety was measured pre-, during and posttest. Results showed that MARS was positively correlated with STAI, but not with the physiological measures. A 3 × 3 mixed ANOVA showed differences between the sedative and no music condition for the measures of STAI and MARS, but not for the physiological measures. Further analyses using t-tests found sedative music to elicit a pronounced decrease in systolic blood pressure and the stimulative music to have minimal effect. To explain these findings and the discrepancy with previous studies, we propose a Perception-to-Physiology model for the effect of music in anxiety.
A calibration process for tracking upper limb motion with inertial sensors

Real-time inertial tracking of human motion requires to attach inertial sensors to the major segments of a human body. Due to the intrinsic noises and drifts of the sensor data, as well as the non-rigidity of the human muscles and skins, the tracking could be unprecise, especially as time elapses. Therefore, an elaborate calibration process and a noise-insensitive tracking algorithm are needed. This paper presents an Extended Kalman Filter-based method for calibrating the relative orientation between human upper limb bones and the sensors attached to them. The calibration result, represented as a rotation matrix, is then used in the tracking of the arm motion with the knowledge of the physical segment kinematic model. Several experiments have been performed to validate the effectiveness of our method.
Disseminated Toxoplasmosis in a Mediterranean Pregnant Risso's Dolphin (Grampus griseus) with Transplacental Fetal Infection

Fatal disseminated toxoplasmosis was diagnosed in a Risso's dolphin (Grampus griseus) dam and its fetus on the basis of pathologic findings, immunohistochemistry, and structure of the parasite. The dolphin was stranded alive on the Spanish Mediterranean coast and died a few hours later. At necropsy the dam was in good condition. From the standpoint of pathology, however, it had generalized lymphadenomegaly and splenomegaly, enlargement of and multifocal hemorrhage in the adrenal glands, diffuse mucosal hemorrhage of the glandular and pyloric stomach, ulcerative glossitis and stomatitis, focal erosions and reddening of the laryngeal appendix, and severe paraotic sinusitis with intralesional nematodes Crassicauda grampicola. The dolphin was pregnant, most probably in the first gestational trimester. The most prominent microscopic lesions were multifocal granulomatous encephalomyelitis, diffuse subacute interstitial pneumonia, mild multifocal necrotizing hepatitis and nonsuppurative cholangiohepatitis, gastritis and adrenalitis, mild lymphoid depletion, medullary sinus and follicular histyocitosis, and systemic hemosiderosis. The fetus had foci of coagulative and lytic necrosis in the kidneys, the lung, and the heart. Most lesions were associated with tachyzoites and tissue cysts of Toxoplasma gondii. The diagnosis was confirmed immunohistochemically. This is the first report on toxoplasmosis in a Risso's dolphin (G. griseus) and on transplacental transmission to an early-stage fetus in any cetaceans.
Rehabilitation of Native Reptiles and Amphibians in DuPage County, Illinois

Between 1980 and 1994, 586 individuals of 20 native reptile and amphibian species were evaluated at a wildlife rehabilitation facility in DuPage County, Illinois (USA). On examination, 48% of reptiles and 52% of amphibians were injured, and 2% of each class were diseased; remaining animals were uninjured. The most frequent causes of injury to reptiles were automobile collisions (55%), ingestion of fishing tackle (19%), and domestic animal attacks (8%). Automobile collisions (38%), lawn and garden accidents (33%), and pet collection (19%) were the most frequent causes of injury to amphibians. We released 354 reptiles and 54 amphibians into appropriate habitat available in local forest preserves, representing case release prevalences of 84% and 68% for each class, respectively.
Life Satisfaction Among Ethnic Minorities in Europe

Although life satisfaction (LS) of ethnic minorities can be significantly undermined by several psychological and material hardships, relatively few studies have examined this issue across Europe. The aim of the present study is to examine the impact of belonging to an ethnic minority group on LS, using data from the sixth wave of the European Social Survey (ESS6), carried out in 2012 in 29 countries (N = 54,540). About 6.7% of all the participants in the ESS6 considered themselves belonging to an ethnic minority group. Our findings show that LS is lower for the ethnic minorities than for the majority not only in the pooled ESS6 sample but also in 19 European countries, most notably in Slovakia and in the Czech Republic. Multilevel analysis indicated that the negative impact of ethnic minority status on LS tended to be enhanced in ex-Communist countries as well as in countries with higher ethnic diversity. The findings of this study show clearly that policy makers of several European countries should focus on increasing social justice and solidarity, and providing ethnic minorities real opportunities to feel more integrated into society.
Rituximab Effectiveness and Safety for Treating Primary Sjögren’s Syndrome (pSS): Systematic Review and Meta-Analysis

Background Primary Sjögren’s Syndrome (pSS) is a systemic autoimmune disease that involves the exocrine glands and internal organs. pSS leads to destruction and loss of secretory function due to intense lymphoplasmacytic infiltration. Therapeutic options include mainly symptomatic and supportive measures, and traditional immunosuppressant drugs have shown no effectiveness in randomized trials. Rituximab (RTX) is a chimeric antibody anti-CD20 that leads to B cell depletion by diverse mechanisms. There is evidence that this drug may be effective for treating pSS. The objective of this systematic review was to evaluate Rituximab effectiveness and safety for treating pSS. Methods and Findings We conducted a systematic review of RCTs published until December 2015, with no language restriction. We registered a protocol on Plataforma Brasil (40654814.6.0000.5505) and developed search strategies for the following scientific databases: MEDLINE, EMBASE, CENTRAL and LILACS. We included adults with established pSS diagnosis and considered the use of Rituximab as intervention and the use of other drugs or placebo as control. Four studies met our eligibility criteria: three with low risk of bias and one with uncertain risk of bias. The total number of participants was 276 (145 RTX, 131 placebo). We assessed the risk of bias of each included study and evaluated the following as primary outcomes: lacrimal gland function, salivary gland function, fatigue improvement and adverse events. We found no significant differences between the groups in the Schirmer test at week 24 meta-analysis (MD 3.59, 95% CI -2.89 to 10.07). Only one study evaluated the lissamine green test and reported a statistically significant difference between the groups at week 24 (MD -2.00, 95% CI -3.52 to -0.48). There was a significant difference between the groups regarding salivary flow rate (MD 0.09, 95% CI 0.02 to 0.16) and improvement in fatigue VAS at weeks 6 (RR 3.98, 95% CI 1.61 to 9.82) and week 16 (RR 3.08, 95% CI 1.21 to 7.80). Conclusions According to moderate quality evidence, the treatment with a single RTX course in patients with SSp presents discrete effect for improving lacrimal gland function. Low-quality evidence indicates the potential of this drug for improving salivary flow. According to low quality evidence, no differences were observed in the evaluation after 24 weeks regarding fatigue reduction (30% VAS), serious adverse events occurrence, quality of life improvement and disease activity. With a very low level of evidence, there was no improvement in oral dryness VAS evaluation.
Effects of an angiotensin II receptor blocker on the impaired function of endothelial progenitor cells in patients with essential hypertension.

BACKGROUND Endothelial progenitor cells (EPCs) induce neovascularization and repair vascular damage. We have demonstrated that EPC function is impaired in hypertensive rats with increases in oxidative stress and that angiotensin II receptor blockers improved the impaired function of EPCs. In this study, we investigated basal EPC functions in normotensive control subjects and patients with essential hypertension and the effect of losartan on EPC function in hypertensive patients. METHODS Eighteen normotensive control subjects and 36 patients with essential hypertension who were undergoing treatment participated in the study. Hypertensive patients were randomly selected to receive 50mg of losartan or 4 mg of trichlormethiazide daily for 4 weeks. Peripheral blood mononuclear cells were isolated and cultured to assay EPC colony formation. Blood pressure, biological examination, and oxidative stress were evaluated in all subjects. RESULTS The number of EPC colonies was significantly lower in patients with essential hypertension than in normotensive control subjects. EPC colony number was significantly and inversely correlated with systolic and diastolic blood pressure in all subjects. EPC colony number was significantly increased by treatment with losartan in patients with essential hypertension but not affected by treatment with trichlormethiazide. CONCLUSIONS EPC function was inversely correlated with blood pressure and was impaired in essential hypertension. Losartan significantly improved the impaired EPC function in hypertensive patients. Impaired EPC function may determine the cardiovascular complications in essential hypertension. The improvement of EPC function with the administration of angiotensin II receptor blockers is considered to be one of the cardiovascular protective effects.
Development and Evaluation of the Panoramic Night Vision Goggle

A novel approach to significantly increasing the field of view (FOV) of night vision goggles (NVGs) has been developed and demonstrated. This approach uses four image intensifier tubes instead of the usual two to produce a very wide 1 0 0 degree horizontal by about 4 0 degree vertical FOV. A conceptual working model, designated the Panoramic NVG, has been fabricated and evaluated.
Blur identification by the method of generalized cross-validation

The point spread function (PSF) of a blurred image is often unknown a priori; the blur must first be identified from the degraded image data before restoring the image. Generalized cross-validation (GCV) is introduced to address the blur identification problem. The GCV criterion identifies model parameters for the blur, the image, and the regularization parameter, providing all the information necessary to restore the image. Experiments are presented which show that GVC is capable of yielding good identification results. A comparison of the GCV criterion with maximum-likelihood (ML) estimation shows the GCV often outperforms ML in identifying the blur and image model parameters.
Current Status of Artemisinin-Resistant falciparum Malaria in South Asia: A Randomized Controlled Artesunate Monotherapy Trial in Bangladesh

Objective Recent reports indicate that first cases of genuine artemisinin resistance have already emerged along the Thai-Cambodian border. The main objective of this trial was to track the potential emergence of artemisinin resistance in Bangladesh, which in terms of drug resistance forms a gateway to the Indian subcontinent. Methods We conducted an open-label, randomized, controlled 42-day clinical trial in Southeastern Bangladesh to investigate the potential spread of clinical artemisinin resistance from Southeast Asia. A total of 126 uncomplicated falciparum malaria patients were randomized to one of 3 treatment arms (artesunate monotherapy with 2 or 4 mg/kg/day once daily or quinine plus doxycycline TID for 7 days). Only cases fulfilling a stringent set of criteria were considered as being artemisinin-resistant. Findings The 28-day and 42-day cure rates in the artesunate monotherapy (2 and 4 mg/kg) and quinine/doxycyline arms were 97.8% (95% confidence interval, CI: 87.8–99.8%), 100% (95% CI: 91.1–100%), and 100% (95% CI: 83.4–100%), respectively. One case of re-infection was seen in the artesunate high dose arm, and a single case of recrudescence was observed in the low dose group on day 26. No differences in median parasite and fever clearance times were found between the 2 artesunate arms (29.8 h and 17.9 h vs. 29.5 h and 19.1 h). Not a single case fulfilled our criteria of artemisinin resistance. Parasite clearance times were considerably shorter and ex vivo results indicate significantly higher susceptibility (50% inhibitory concentration for dihydroartemisinin was 1.10 nM; 95% CI: 0.95–1.28 nM) to artemisinins as compared to SE-Asia. Conclusion There is currently no indication that artemisinin resistance has reached Bangladesh. However, the fact that resistance has recently been reported from nearby Myanmar indicates an urgent need for close monitoring of artemisinin resistance in the region. Trial Registration ClinicalTrials.gov NCT00639873.