Miracle-dz/UniFAR-FTUs huggingface dataset:
Many faces of a gifted personality : characteristics along a complex gifted spectrum

This article will explore attempts to categorise gifted children according to certain types, and examine attempts to find common gifted characteristics, including characteristics that may have resulted from adverse environmental and other influences affecting attachment security. The discussion will highlight the difficulty in identifying gifted children who have associated disorders, as the disorders can affect core gifted characteristics. If this were the case, then seemingly discrepant and unexpected behaviours in some gifted children may be explained by such disorders. It will be argued that characteristics can be reliably used to initially screen children for both giftedness and for more commonly associated disorders, including anxiety and ADHD. A screening tool, The Spectrum of Gifted Characteristics, includes characteristics of disorders more frequently associated with giftedness, characteristics associated with attachment, and predicted gifted characteristics when combined with separate disorders and attachment styles.
The evolution of colour polymorphism in British winter‐active Lepidoptera in response to search image use by avian predators

Phenotypic polymorphism in cryptic species is widespread. This may evolve in response to search image use by predators exerting negative frequency‐dependent selection on intraspecific colour morphs, ‘apostatic selection’. Evidence exists to indicate search image formation by predators and apostatic selection operating on wild prey populations, though not to demonstrate search image use directly resulting in apostatic selection. The present study attempted to address this deficiency, using British Lepidoptera active in winter as a model system. It has been proposed that the typically polymorphic wing colouration of these species represents an anti‐search image adaptation against birds. To test (a) for search image‐driven apostatic selection, dimorphic populations of artificial moth‐like models were established in woodland at varying relative morph frequencies and exposed to predation by natural populations of birds. In addition, to test (b) whether abundance and degree of polymorphism are correlated across British winter‐active moths, as predicted where search image use drives apostatic selection, a series of phylogenetic comparative analyses were conducted. There was a positive relationship between artificial morph frequency and probability of predation, consistent with birds utilizing search images and exerting apostatic selection. Abundance and degree of polymorphism were found to be positively correlated across British Lepidoptera active in winter, though not across all taxonomic groups analysed. This evidence is consistent with polymorphism in this group having evolved in response to search image‐driven apostatic selection and supports the viability of this mechanism as a means by which phenotypic and genetic variation may be maintained in natural populations.
Female Veterans With Diagnoses of Both Chronic Pelvic Pain and Overactive Bladder; How Do They Compare to Women Diagnosed With Interstitial Cystitis?

Women with the dual diagnosis of overactive bladder and pelvic pain, symptoms similar to interstitial cystitis, have an increased risk of anxiety. Objective The objective of this study was to compare women with a known diagnosis of interstitial cystitis (IC) to a population that might be at risk for the diagnosis of IC, women with diagnoses of both chronic pelvic pain (CPP) and overactive bladder (OAB). Methods We conducted a retrospective study of data from the Veterans Affairs Corporate Data Warehouse. The cohort included all female veterans who had established care with a primary care provider from 1997 to present. International Classification of Diseases, Ninth Revision codes were used to identify women with a diagnosis of IC, CPP, and OAB. Demographic data and comorbidities were compared between groups. Results A total of 596,815 women were identified. Two thousand three hundred one women (0.4%) were diagnosed with IC; 4459 women (0.7%) were diagnosed with CPP and OAB. At baseline, women with OAB and CPP were more likely to identify as minority (P < 0.001). Anxiety (57.3% vs 49.5%), depression (39.0% vs 46.0%), and posttraumatic stress disorder (29.7 vs 26.4%) were all more common in the CPP and OAB group than in the IC group. In the multivariable model, women with CPP and OAB were more likely to identify as a minority, use tobacco, and carry a diagnosis of anxiety. Conclusions There were more patients diagnosed with CPP and OAB compared with patients diagnosed with IC in this population of female veterans. Given the high rate of comorbid anxiety and depression in both groups, further study is warranted to determine whether these women are misdiagnosed.
GCF Elastase and Interleukin-8, and the Treatment Outcome of Scaling and Root Planing

This six-month longitudinal study quantified gingival crevice fluid elastase and interleukin-8 and analysed their relationship to clinical outcome of mechanical therapy. Eighteen patients with chronic periodontitis, presenting 209 sites, were included in the study (123 periodontitis, 45 gingivitis and 41 healthy sites). After oral hygiene instructions and supragingival scaling, periodontitis sites were root planed. Gingival crevice fluid was collected twice before treatment within 10 days, and two weeks, two and six months thereafter. Elastase was determined using a fluorogenic substrate, and interleukin-8 was quantified using enzyme-linked immunosorbent assay. Clinical parameters included pocket probing depths, bleeding on probing and plaque scores. Therapy resulted in highly significant reductions of elastase and interleukin-8 in all three categories of sites. Eleven periodontitis sites, distributed in six subjects, remained at six months with pockets greater than 5mm. At baseline and at two months these sites showed significantly higher levels of pocket probing depths and bleeding on probing (p < 0.01), whereas no difference was noted for elastase and interleukin-8. On the subject level, however, no difference was noted at baseline between these six patients and the other ones. Clinical improvement after periodontal therapy was associated with a highly significant reduction in elastase and interleukin-8 levels. Whereas probing depth and bleeding on probing at baseline reflected the clinical outcome, the biochemical parameters did not.
Validation of a spectral light‐photosynthesis model and use of the model in conjunction with remotely sensed pigment observations

The predictions ofa spectral light-photosynthesis model are compared with field data. The model calculations are based on pigment (chlorophyll and pheophytin) and temperature profiles and, when available, on irradiance recorded on deck. The agreement between computed and measured production values is satisfying over the full range (lo-‘1 g C m-j d-l or 0.03-10 g C m-2 d-l). It is better when l“C fixation has been measured via the in situ method; a small bias appears when production was measured on deck (simulated in situ method). In both cases however the standard deviation remains similar and computed and measuresd column production agrees within a factor of - 3. The same data set is also used to predict column production from pigment concentration within only the top layer, as supposedly remotely sensed. The model is run in combination with pigment profiles, which are “reconstructed” (in magnitude and shape) as a function of the upper layer concentration with statistical relationships previously established. The agreement between computed and measured production (within a factor 3.3 at 1 SD) is encouraging. The model uses mean and constant physiological parameters, which actually vary in the natural environment. Among these parameters, the Chl-specilic absorption by phytoplankton algae and, to a lesser extent, the maximum quantum yield for growth are crucial. Very likely their variations are the main causes of divergence between predicted and field values.
Seasonal Changes in Proximate Composition and Mineral-Heavy Metal Content of Pufferfish ( Lagocephalus sceleratus ) from Northeastern Mediterranean Sea

In this study, it was aimed to determine the chemical composition of the pufferfish (Lagocephalus sceleratus) caught from Mersin Bay in the Northeastern Mediterranean Sea. For this purpose, the proximate composition, fatty acid profile, mineral and heavy metal levels were investigated. Pufferfish samples were caught using trawl fishing technique over four seasons between December 2012 and October 2013. As a result of the study, the average protein, lipid, water and total mineral substance (TMS) levels for female individuals were determined to be 20.44%, 0.65%, 76.98% and 1.43% respectively; while for male individuals these were determined to be 20.58%, 0.84%, 76.68% and 1.40%. In the fatty acid composition of L. sceleratus; total saturated fatty acids (SFA) level was determined to be between 24.78% and 29.75%, total monounsaturated fatty acid (MUFA) level was 15.41% to 23.20%, total polyunsaturated fatty acid (PUFA) level was 39.90% to 45.70%. Macro, trace element and toxic heavy metal levels in pufferfish muscle tissue were determined using ICP-MS. The relationship between the amounts of macro and trace elements in L. sceleratus was determined to be K>P>Na>Mg>Ca and Zn>Se>Cu>Ni>Mo>Co for both sexes. In the muscle tissues of pufferfish, Cd levels were found to be over limit levels.
Comparative Phylogeny and Historical Perspectives on Population Genetics of the Pacific Hawksbill (Eretmochelys imbricata) and Green Turtles (Chelonia mydas), Inferred from Feeding Populations in the Yaeyama Islands, Japan

Mitochondrial DNA sequence polymorphisms and patterns of genetic diversity represent the genealogy and relative impacts of historical, geographic, and demographic events on populations. In this study, historical patterns of population dynamics and differentiation in hawksbill (Eretmochelys imbricata) and green turtles (Chelonia mydas) in the Pacific were estimated from feeding populations in the Yaeyama Islands, Japan. Phylogenetic relationships of the haplotypes indicated that hawksbill and green turtles in the Pacific probably underwent very similar patterns and processes of population dynamics over the last million years, with population subdivision during the early Pleistocene and population expansion after the last glacial maximum. These significant contemporary historical events were suggested to have been caused by climatic and sea-level fluctuations. On the other hand, comparing our results to long-term population dynamics in the Atlantic, population subdivisions during the early Pleistocene were specific to Pacific hawksbill and green turtles. Therefore, regional differences in historical population dynamics are suggested. Despite limited sampling locations, these results are the first step in estimating the historical trends in Pacific sea turtles by using phylogenetics and population genetics.
High risk of stent thrombosis in the first 6 months after coronary stenting: Do not discontinue clopidogrel early after ACS

OBJECTIVES To estimate the incidence of stent thrombosis (ST) after early discontinuation of clopidogrel. BACKGROUND Premature discontinuation of clopidogrel is the strongest risk factor for ST. In contrast, recent studies suggest that shorter dual antiplatelet therapy (DAPT) can be discontinued as soon as 3 months after stenting. However, these studies included very few ACS patients and were not powered for ST. Hence, little is known about the occurrence of ST in high-risk populations when DAPT is discontinued early. METHODS This is a subanalysis of The Dutch ST Registry 437 ST cases (mainly first-generation DES and BMS). Acute coronary syndrome was the indication for index-PCI in 74% of the patients. Clopidogrel discontinuation rates in ST patients and matched controls were used to calculate the absolute incidence of ST after early clopidogrel discontinuation. RESULTS The overall rate of ST after cessation of clopidogrel was 4.6% (95%CI: 3.9-5.4%), as compared to 1.7% (95%CI: 1.5-1.9%) in patients who did not discontinue clopidogrel. The incidence of ST was 35.4% when clopidogrel was discontinued in the first 30 days after index-PCI declining to 11.7% when clopidogrel was discontinued in the first 180 days. CONCLUSIONS This dedicated ST registry shows that ST rates were very high when clopidogrel was discontinued before 6 months after index-PCI and therefore suggests that clopidogrel discontinuation in the first 6 months after ACS should be avoided.
Reflective coating for lightweight x-ray optics

X-ray reflective coating for next generation’s lightweight, high resolution optics for astronomy requires thin-film deposition that is precisely fine-tuned so that it will not distort the thin sub-mm substrates. Film of very low stress is required. Films with multi-layer or bi-layer can be deposited to give an effective low stress which cause negligible distortion. Alternatively, mirror distortion can be cancelled by precisely balancing the deformation by coating films on both sides of the substrates. We have been developing techniques to coat glass substrates that can provide good reflectivity in the soft x-ray band below 10 keV, and yet introduce negligible surface distortion for arc-second optics. These efforts include: low-stress deposition by magnetron sputtering and atomic layer deposition of the metals, balancing of gross deformation with two-layer depositions of opposite stresses and with depositions on both sides of the thin mirrors.
Prevalence of Chronic Kidney Disease in an Urban HIV Infected Population

Background:The prevalence of chronic kidney disease in an HIV-infected population during the highly active antiretroviral era has not been fully evaluated. Methods:A retrospective chart review of HIV-infected patients seen in 2004 was conducted to determine the prevalence of chronic kidney disease (CKD), using the 2004 National Kidney Foundation's CKD staging criteria. Glomerular filtration rate (GFR) was calculated, using the Modification of Diet in Renal Disease formula. Univariate analyses were performed comparing individuals with normal kidney function and those with CKD. Multivariate analysis was conducted including all variables with a value of P < 0.1. Results:We found evidence of CKD in 24% of the patients. Forty patients (10%) had stage 1 CKD, 19 patients (4%) stage 2, 29 patients (7%) stage 3, 4 patients (1%) stage 4, and 8 patients (2%) stage 5. Patients with CKD are more likely to be African American (AA), older, have AIDS, lower CD4 counts and higher HIV viral loads. Patients with CKD were also more likely to have hypertension (HTN), diabetes mellitus (DM), or both. Indinavir or tenofovir exposure was associated with CKD. In multivariate analysis HTN, AA race, or HTN and DM were the only significant predictors of CKD. Physicians did not identify CKD in 74% of patients. Renal biopsies were done in 10 patients; 5 had HIV-associated nephropathy. Conclusions:Substantial minorities of HIV-infected patients have CKD. AA race or the presence of HTN or HTN and DM is associated with CKD. Clinicians often do not note the presence of CKD in this population.
Insight, Motivation and Outcome in Drug Treatment for Offenders: A Review of the Recent Literature

Researchers in addiction and psychotherapy have long agreed that insight into problem severity and motivation for treatment are important client factors in successful treatment. For offenders these factors are linked to recidivism and relapse rates post-treatment. Authors in both fields agree that the combination of insight and motivation are key to positive treatment outcomes. However, this literature review found little effort to measure these factors in substance abuse literature with offenders. Articles identified contained the terms ‘motivation;’ ‘insight;’ and ‘drug treatment’ were paired with the term ‘offenders’ in varying combinations to identify articles meeting study criteria. Inductive analysis revealed that the majority of the articles did not measure insight and motivation, nor did they measure outcomes. Only seven of the 16 articles included measures of insight and motivation. Of these, only one study measured outcome as well. In addition, qualitative aspects of insight and motivation were not accounted for by assessments used. Recommendations for future research include measuring insight and motivation as well as treatment outcome, and tailoring treatment for this population accordingly, so as to better predict recidivism rates post-treatment.
See What You Think

The social environment requires people to quickly form contextually appropriate social evaluations. Models of social cognition suggest that this ability depends on the interaction of automatic and controlled evaluative systems. However, controlled processes, such as reappraisal of an initial response, have rarely been studied in the context of social evaluation. In the two studies reported here, participants reappraised or simply observed angry or neutral faces. In Study 1, reappraisal modulated evaluations of angry faces on explicit as well as implicit behavioral levels. In Study 2, reappraisal altered both early and late phases of evaluative electrocortical processing. These studies suggest that controlled processes, such as reappraisal, can quickly and substantially modulate early evaluative processes in the context of biologically significant social stimuli.
Excitatory motor neurons are local oscillators for backward locomotion

Cell- or network-driven oscillators underlie motor rhythmicity. The identity of C. elegans oscillators remains unknown. Through cell ablation, electrophysiology, and calcium imaging, we show: (1) forward and backward locomotion is driven by different oscillators; (2) the cholinergic and excitatory A-class motor neurons exhibit intrinsic and oscillatory activity that is sufficient to drive backward locomotion in the absence of premotor interneurons; (3) the UNC-2 P/Q/N high-voltage-activated calcium current underlies A motor neuron’s oscillation; (4) descending premotor interneurons AVA, via an evolutionarily conserved, mixed gap junction and chemical synapse configuration, exert state-dependent inhibition and potentiation of A motor neuron’s intrinsic activity to regulate backward locomotion. Thus, motor neurons themselves derive rhythms, which are dually regulated by the descending interneurons to control the reversal motor state. These and previous findings exemplify compression: essential circuit properties are conserved but executed by fewer numbers and layers of neurons in a small locomotor network.
Real-world effectiveness and safety of oral anticoagulation strategies in atrial fibrillation: a cohort study based on a German claims dataset

Objective To compare the real-world effectiveness and safety of non-vitamin-K-antagonist oral anticoagulant (NOAC) treatment in atrial fibrillation (AF) patients with a vitamin-K-antagonist (VKA)-based treatment. Methods This was a retrospective analysis of an anonymized claims dataset from 3 German health insurance funds covering the period from January 01, 2010 to June 30, 2014, with a minimum observation time of 12 months. All continuously insured patients with at least 2 outpatient AF diagnoses and/or 1 inpatient respective diagnosis who received at least 1 outpatient prescription of a NOAC or VKA were included. Outcomes and measures Death, ischemic strokes (IS), non-specified strokes, transient ischemic attacks (TIAs), myocardial infarctions (MIs), arterial embolism (AE), hemorrhagic strokes, severe bleedings, and composite outcomes. Main comparisons were done based on propensity score-matched (PSM) cohorts. Results were reported as incidence rate ratios and hazard ratios (HRs). Results We assigned 37,439 AF patients to each PSM cohort (NOAC cohort: mean age 78.2 years, mean CHA2DS2VASc score 2.96, mean follow-up 348.5 days; VKA cohort: mean age 78.2 years, mean CHA2DS2VASc 2.95, mean follow-up 365.5 days). NOAC exposure was associated with significantly higher incidence rate ratios; 95% CI/HRs; 95% CI for the following outcomes: death (1.22; 1.17–1.28/1.22; 1.17–1.28), IS (1.90; 1.69–2.15/1.92; 1.69–2.19), non-specified strokes (2.04; 1.16–3.70/1.93; 1.13–3.32), TIAs (1.52; 1.29–1.79/1.44; 1.21–1.70), MIs (1.26; 1.10–1.15/1.31; 1.13–1.52), AE (1.75; 1.32–2.32/1.81; 1.36–2.34) and severe bleeding (1.92; 1.71–2.15/1.95; 1.74–2.20). Multivariable Cox regression analyses and additional sensitivity analysis, including analysis of PSM-matched NOAC/VKA treatment-naive patients, only confirmed the above results. The study was documented under clinicaltrials.gov (NCT02657616). Conclusion and relevance A VKA therapy seems to be more effective and safer than a NOAC therapy in a real-world cohort of German AF patients.
Bacterial and Mucopeptide Concretions of the Lacrimal Drainage System: An Analysis of 30 Cases

Purpose: To demonstrate the histopathologic characteristics of different types of lacrimal drainage system concretions with clinical correlations. Methods: Thirty lacrimal drainage system concretions submitted to the Cogan Eye Pathology Laboratory at the Massachusetts Eye and Ear Infirmary over a 2-year period were reviewed. Concretions were studied in detail using their histopathologic staining features as revealed with hematoxylin and eosin, Gomori methenamine silver, periodic acid-Schiff, iron stain, and Brown-Hopps tissue gram stain. A separate retrospective chart review was conducted for each patient to identify any clinical correlations. Results: Two major forms of concretions were identified histopathologically: mucopeptide (7) and bacterial (20). Mucopeptide concretions were found exclusively within the lacrimal sac, while bacterial concretions were found chiefly in the canaliculus. A third category of “mixed” concretions with substantial mucopeptide and bacterial characteristics comprised 3 specimens. Bacterial concretions consisted of large matted masses of filamentous, presumed Actinomyces organisms that were easily identified with the Grocott’s methenamine silver stain; they were frequently cocolonized at their edges with coccal bacterial forms. Mucopeptide concretions were generally devoid of cellular elements and were composed of broad bland whorls of diffusely eosinophilic, acellular, periodic acid-Schiff-positive material punctuated by lacunae. They were often cocolonized by small numbers of bacterial cocci and occasional fungi. Culture results disclosed low virulence species. All 3 types of concretions predominated in women. Patients with bacterial concretions frequently had dry eye symptoms. Conclusions: The 2 major types of lacrimal system concretions differ in their primary location and histopathologic composition. Further characterization may lead to an understanding of the mechanisms for their formation. Mucopeptide concretion is more appropriate than terms such as “dacryolith” and “mucolith,” and bacterial concretion is a more appropriate term than “canaliculith,” because of the absence of significant calcium or stone-like density in these masses.