Miracle-dz/UniFAR-FTUs huggingface dataset:
How Do Low-Income Urban African Americans and Latinos Feel about Telemedicine? A Diffusion of Innovation Analysis

Introduction. Telemedicine is promoted as a means to increase access to specialty medical care among the urban underserved, yet little is known about its acceptability among these populations. We used components of a diffusion of innovation conceptual framework to analyze preexperience perceptions about telemedicine to assess its appeal among urban underserved African Americans and Latinos. Methods. Ten focus groups were conducted with African American (n = 43) and Latino participants (n = 44) in both English and Spanish and analyzed for key themes. Results. Both groups perceived increased and immediate access to multiple medical opinions and reduced wait time as relative advantages of telemedicine. However, African Americans expressed more concerns than Latinos about confidentiality, privacy, and the physical absence of the specialist. This difference may reflect lower levels of trust in new health care innovations among African Americans resulting from a legacy of past abuses in the US medical system as compared to immigrant Latinos who do not have this particular historical backdrop. Conclusions. These findings have implications for important issues such as adoption of telemedicine, patient satisfaction, doctor-patient interactions, and the development and tailoring of strategies targeted to each of these populations for the introduction, marketing, and implementation of telemedicine.
Differences between the clinical and histopathological tumor stages in breast cancer diagnosed using vacuum-assisted breast biopsy

The present study aimed to determine the difference between the clinical tumor stage (T stage) based on pre-operative ultrasound and the histopathological T stage subsequent to surgery in vacuum-assisted breast biopsy (VABB)-diagnosed breast cancer. Tumor sizes measured ultrasonography (USG) and histologically were retrospectively calculated and analyzed using paired t-tests in 209 patients diagnosed with breast cancer using VABB. The patients were classified into two groups, consisting of breast imaging reporting and data system (BI-RADS) category 4a or below, who underwent complete resection by VABB, and BI-RADS category 4b or above, who underwent incisional biopsy by VABB. The histopathological tumor size was found to be smaller compared with the USG-determined size in 92.3% of pT1a, 75.5% of pT1b, 44.2% of pT1c, 47.7% of pT2 and 0% of pT3 cases. Furthermore, the histopathological tumor size was smaller compared with the USG-determined size in 62.8% of cases classified as BI-RADS category 3-4a and in 53.7% of cases classified as BI-RADS category 4b-5. The smaller the primary tumor at the time of diagnosis by VABB, the higher the likelihood of pathological underestimation on post-operative histopathological assessment compared to pre-operative USG.
ETIOLOGIC RELATIONSHIPS BETWEEN ANXIETY AND DIMENSIONS OF MALADAPTIVE PERFECTIONISMIN YOUNG ADULT FEMALE TWINS

Theory and research suggest that maladaptive perfectionism, specifically, concerns about mistakes (CM) and doubts about actions (DA), may be important etiologic and maintenance mechanisms for anxiety and its disorders. However, no studies speaking directly to the origins of the relationship, i.e. what etiologic factors underlie the phenotypic association between anxiety and maladaptive perfectionism, exist. The current study aimed to address this gap in the literature by exploring genetic and environmental relationships between anxiety symptoms and maladaptive perfectionism.
Intangibles Disclosure Information on Internet by Multinational Corporations

Rapid developments in information and communications technology, especially with regard to Internet, have caused a substantial impact on the delivery and dissemination of business information. Internet reporting is expected to bring significant benefits to reporting companies, including facilitating access to potential investors an other stakeholders, disseminating information more quickly, more widely and at less cost, providing a platform to integrate different technologies and reducing the cost of providing hard copy annual reports. In this paper, we have examined the extent and the way companies use Internet to provide information about their intangibles. We have established for the Standard & Poor's GLOBAL 100 Index companies, different Internet intangibles disclosure indexes, and we have contrasted which variables explain the disclosure of this intangible information on Internet. Results show that the region of origin, especially in the European companies, and the intensity of the intangible expenditures are the main factors that explain the differences in the extent of corporate intangible disclosure on Internet.
Internalizing and Externalizing Problems in Children of War Veterans in Kosovo

The aim of this study was to explore internalizing and externalizing problems in adolescent children of veterans of the war in Kosovo (1998-1999). The results of this study are quite interesting from the perspective of the dilemma for the state of the children of veterans even 15 years after the war ended. Parents’ emotional problems affect the functioning of the family in general and children in particular. Children can react to symptoms of parents by developing different symptoms as trouble sleeping, appetite loss, emotional instability or even problems in development, according to research done on children's reactions to the problems of parents explained by interactions between environment, brain and behaviour driven by trauma. The results of this study have shown that the internalizing problems have not shown gender differences, meantime externalizing problems were found higher in male participants. An interesting finding of this study was the highest scores of emotional problems in children born before and during the war, compare to those born after the war ended. We also found that anxiety problems in children [R2= . 83, p < . 001] were a significant predictor of internalizing problems. The assessment of the scale of positive qualities [R2= . 19, p < . 001] was also found to be a significant predictor for externalizing problems.Only 0.8% of the variance of internalizing problems was explained by the income. Considering that the subject of this study were adolescent children of war veterans of the 1999 conflict in Kosovo, we must take into account that the post-traumatic stress disorder is a very frequent problem among war veterans and that its impact on their personal and family life cannot be overlooked.
CEO transformational leadership and the new product development process

Purpose – The purpose of this paper is to examine the linkages between CEO transformational leadership and the new product development (NPD) process through organizational learning and innovation culture. Design/methodology/approach – A large-scale survey by a sample of 269 manufacturing firms in Thailand was conducted. Structural equation modeling was used to test the proposed relationships. Findings – CEO transformational leadership was strongly and positively associated with organizational learning and innovation culture. Additionally, organizational learning and innovation culture were positively related to the NPD process. Practical implications – Managers should pay more attention to organizational learning since it has a strong impact on the NPD process. CEOs with an innovation-oriented attitude should develop their transformational leadership to support organizational learning and an innovation culture. Originality/value – The study extends the understanding of the connections between CEO transformational leadership and the NPD process. The results highlight the mediating roles of organizational learning and innovation culture on the relationship between CEO transformational leadership and the NPD process.
An analytic model for the spatial clustering of dark matter haloes

We develop a simple analytic model for the gravitational clustering of dark matter haloes to understand how their spatial distribution is biased relative to that of the mass. The statistical distribution of dark haloes within the initial density field (assumed Gaussian) is determined by an extension of the Press-Schechter formalism. Modifications of this distribution caused by gravitationally induced motions are treated using a spherical collapse approximation. We test this model against results from a variety of N-body simulations, and find that it gives an accurate description of a bias function. This bias function is sufficient to calculate the cross-correlation between dark haloes and mass, and again we find excellent agreement between simulation results and analytic predictions. Because haloes are spatially exclusive, the variance in the count of objects within spheres of fixed radius and overdensity is significantly smaller than the Poisson value. This seriously complicates any analytic calculation of the autocorrelation function of dark halos. Our simulation results show that this autocorrelation function is proportional to that of the mass over a wide range in $R$, even including scales where both functions are significantly greater than unity. The constant of proportionality is very close to that predicted on large scales by the analytic model. This result permits an entirely analytic estimate of the autocorrelation function of dark haloes. We use our model to study how the distribution of galaxies may be biased with respect to that of the mass. In conjunction with other data these techniques should make it possible to measure the amplitude of cosmic mass fluctuations and the density of the Universe.
Contextual Model-Based Collaborative Filtering for Recommender Systems

Recommender systems have dramatically changed the way we consume content. Internet applications rely on these systems to help users navigate among the ever-increasing number of choices available. However, most current systems ignore that user preferences can change according to context, resulting in recommendations that do not fit user interests. Context-aware models have been proposed to address this issue, but these models have problems of their own. The ever-increasing speed at which data are generated presents a scalability challenge for single-model approaches. Moreover, the complexity of these models prevents small players from adapting and implementing contextual models that meet their needs. This thesis addresses these issues by proposing the (CF) 2 architecture, which uses local learning techniques to embed contextual awareness into collaborative filtering (CF) models. CF has been available for decades, and its methods and benefits have been extensively discussed and implemented. Moreover, the use of context as filtering criteria for local learning addresses the scalability issues caused by the use of large datasets. Therefore, the proposed architecture enables the creation of contextual recommendations using several models instead of one, with each model representing a context. In addition, the architecture is implemented and evaluated in two case studies. Results show that contextual models trained with a small fraction of the data resulted in similar or better accuracy compared to CF models trained with the total dataset. Moreover, experiments indicate that local learning using contextual information outperforms random selection in accuracy and in training time.
Hypertension in India: a systematic review and meta-analysis of prevalence, awareness, and control of hypertension

Background: A region-specific (urban and rural parts of north, east, west, and south India) systematic review and meta-analysis of the prevalence, awareness, and control of hypertension among Indian patients have not been done before. Methods: Medline, Web of Science, and Scopus databases from 1950 to 30 April 2013 were searched for ‘prevalence, burden, awareness, and control of blood pressure (BP) or hypertension (≥140 SBP and or ≥90 DBP) among Indian adults’ (≥18 years). Of the total 3047 articles, 142 were included. Results: Overall prevalence for hypertension in India was 29.8% (95% confidence interval: 26.7–33.0). Significant differences in hypertension prevalence were noted between rural and urban parts [27.6% (23.2–32.0) and 33.8% (29.7–37.8); P = 0.05]. Regional estimates for the prevalence of hypertension were as follows: 14.5% (13.3–15.7), 31.7% (30.2–33.3), 18.1% (16.9–19.2), and 21.1% (20.1–22.0) for rural north, east, west, and south India; and 28.8% (26.9–30.8), 34.5% (32.6–36.5), 35.8% (35.2–36.5), and 31.8% (30.4–33.1) for urban north, east, west, and south India, respectively. Overall estimates for the prevalence of awareness, treatment, and control of BP were 25.3% (21.4–29.3), 25.1% (17.0–33.1), and 10.7% (6.5–15.0) for rural Indians; and 42.0% (35.2–48.9), 37.6% (24.0–51.2), and 20.2% (11.6–28.7) for urban Indians. Conclusion: About 33% urban and 25% rural Indians are hypertensive. Of these, 25% rural and 42% urban Indians are aware of their hypertensive status. Only 25% rural and 38% of urban Indians are being treated for hypertension. One-tenth of rural and one-fifth of urban Indian hypertensive population have their BP under control.
Pulmonary complications after abdominal surgery in patients with mild-to-moderate chronic obstructive pulmonary disease

Postoperative pulmonary complications (PPCs) are one of the most important causes of postoperative morbidity and mortality after abdominal surgery. Although chronic obstructive pulmonary disease (COPD) has been considered a risk factor for PPCs, it remains unclear whether mild-to-moderate COPD is a risk factor. This retrospective cohort study included 387 subjects who underwent abdominal surgery with general anesthesia in a tertiary referral hospital. PPCs included pneumonia, pulmonary edema, pulmonary thromboembolism, atelectasis, and acute exacerbation of COPD. Among the 387 subjects, PPCs developed in 14 (12.0%) of 117 patients with mild-to-moderate COPD and in 13 (15.1%) of 86 control patients. Multiple logistic regression analysis revealed that mild-to-moderate COPD was not a significant risk factor for PPCs (odds ratio [OR] =0.79; 95% confidence interval [CI] =0.31–2.03; P=0.628). However, previous hospitalization for respiratory problems (OR =4.20; 95% CI =1.52–11.59), emergency surgery (OR =3.93; 95% CI =1.75–8.82), increased amount of red blood cell (RBC) transfusion (OR =1.09; 95% CI =1.05–1.14 for one pack increase of RBC transfusion), and laparoscopic surgery (OR =0.41; 95% CI =0.18–0.93) were independent predictors of PPCs. These findings suggested that mild-to-moderate COPD may not be a significant risk factor for PPCs after abdominal surgery.
Identification and Characterization of a Lupus Suppressor 129 Locus on Chromosome 3

The 129-derived Sle16 is a susceptibility locus for systemic autoimmunity when present on the C57BL/6 (B6) background. Genetic analysis of a (129×B6)F2 cross identified a region from the B6 chromosome 3 (Sle18) with positive linkage to antinuclear Abs. In this study, we have generated a B6 congenic strain harboring the 129 allele of Sle18 and intercrossed this line with the lupus-prone B6.129-Sle16 strain. The presence of the 129-Sle18 allele in the B6.129-Sle16Sle18 double congenic mice suppressed the development of Sle16-mediated autoantibody production and ameliorated the renal pathology. The 129-Sle18 locus rectified the B cell abnormalities detected in the B6.129-Sle16 mice, such as the reduction in the percentage of marginal zone B and B1a cells and the increased number of germinal centers. The B6.129-Sle16Sle18 spleens still displayed an increased percentage of activated T and B cells. However, in the B6.129-Sle16Sle18 strain the percentage of naive T cells was equivalent to that in B6.129-Sle18 and B6 mice and these cells showed a reduced proliferative response to anti-CD3 stimulation compared with B6.129-Sle16 T cells. There was a significant increase in the percentage of CD4+FoxP3+regulatory T cells in all congenic strains. These cells had normal regulatory function when tested in vitro. Thus, 129-Sle18 represents a novel, non-MHC lupus-suppressor locus probably operating as a functional modifier of B cells that, in combination with other factors, leads to lupus resistance. Further characterization of this locus will help to uncover the immune mechanism(s) conferring protection against lupus.
A Regret-Induced Status Quo Bias

A suboptimal bias toward accepting the status quo option in decision-making is well established behaviorally, but the underlying neural mechanisms are less clear. Behavioral evidence suggests the emotion of regret is higher when errors arise from rejection rather than acceptance of a status quo option. Such asymmetry in the genesis of regret might drive the status quo bias on subsequent decisions, if indeed erroneous status quo rejections have a greater neuronal impact than erroneous status quo acceptances. To test this, we acquired human fMRI data during a difficult perceptual decision task that incorporated a trial-to-trial intrinsic status quo option, with explicit signaling of outcomes (error or correct). Behaviorally, experienced regret was higher after an erroneous status quo rejection compared with acceptance. Anterior insula and medial prefrontal cortex showed increased blood oxygenation level-dependent signal after such status quo rejection errors. In line with our hypothesis, a similar pattern of signal change predicted acceptance of the status quo on a subsequent trial. Thus, our data link a regret-induced status quo bias to error-related activity on the preceding trial.
Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells

Over recent years, we have demonstrated that Frondoside A, a triterpenoid glycoside isolated from an Atlantic sea cucumber, has potent in vitro and in vivo anti-cancer effects against human pancreatic, breast, and lung cancer. We have also demonstrated that Frondoside A is able to potentiate and/or synergize the anti-cancer effects of major classical cytotoxic agents, namely, gemcitabine, paclitaxel, and cisplatin, in the treatment of pancreatic, breast, and lung cancer, respectively. This study evaluates the impact of Frondoside A alone and in combination with the standard cytotoxic drugs oxaliplatin and 5-fluorouracil (5-FU) in the treatment of colon cancer using three human colon cancer cell lines, namely, HT-29, HCT-116, and HCT8/S11. We demonstrate that Frondoside A, oxaliplatin, and 5-FU cause a concentration- and time-dependent reduction in the number of HT-29 colon cancer cells. A concentration of 2.5 µM of Frondoside A led to almost 100% inhibition of cell numbers at 72 h. A similar effect was only observed with a much higher concentration (100 µM) of oxaliplatin or 5-FU. The reduction in cell numbers by Frondoside A, oxaliplatin, and 5-FU was also confirmed in two other colon cancer cell lines, namely, HCT8/S11 and HCT-116, treated for 48 h. The combinations of low concentrations of these drugs for 48 h in vitro clearly demonstrated that Frondoside A enhances the inhibition of cell numbers induced by oxaliplatin or 5-FU. Similarly, such a combination also efficiently inhibited colony growth in vitro. Interestingly, we found that the inhibition of ERK1/2 phosphorylation was significantly enhanced when Frondoside A was used in combination treatments. Moreover, we show that Frondoside A and 5-FU, when used alone, induce a concentration-dependent induction of apoptosis and that their pro-apoptotic effect is dramatically enhanced when used in combination. We further demonstrate that apoptosis induction upon the treatment of colon cancer cells was at least in part a result of the inhibition of phosphorylation of the survival kinase AKT, leading to caspase-3 activation, poly (ADP-ribose) polymerase (PARP) inactivation, and consequently DNA damage, as suggested by the increase in the level of γH2AX. In light of these findings, we strongly suggest that Frondoside A may have a role in colon cancer therapy when used in combination with the standard cytotoxic drugs oxaliplatin and 5-FU.
Long-term evolution of antigen repertoires among carried meningococci

Most studies of bacterial pathogen populations have been based on isolates collected from individuals with disease, or their contacts, over short time periods. For commensal organisms that occasionally cause disease, such as Neisseria meningitidis, however, the analysis of isolates from long-term asymptomatic carriage is necessary to elucidate their evolution and population structure. Here, we use mathematical models to analyse the structuring and dynamics of three vaccine-candidate antigens among carried meningococcal isolates collected over nearly 30 years in the Czech Republic. The data indicate that stable combinations of antigenic alleles were maintained over this time period despite evidence for high rates of recombination, consistent with theoretical models in which strong immune selection can maintain non-overlapping combinations of antigenic determinants in the presence of recombination. We contrast this antigenic structure with the overlapping but relatively stable combinations of the housekeeping genes observed among the same isolates, and use a novel network approach to visualize these relationships.
A Contract Perspective on the International Finance Facility

The present paper is a first attempt to develop a theoretical model using a short-term vis-a-vis long-term contract framework within which donor countries' endorsement or rejection decision towards the recently proposed International Finance Facility (IFF) is rationalized. The current foreign aid system is portrayed as being similar to a series of short-term contracts, where donor countries are able to adjust the aid amount to reflect environmental change (broadly defined to take into account changes in public opinion, domestic situation, etc.).
Negotiating diasporic Black African existence in Australia: a reflexive analysis

The past twenty years has seen a somewhat steady flow of continental Africans into Australia. The arrival of such people, often constructed as 'blacks,' raises several questions with respect to identity and belonging. For example, what does it mean to be and 'live black' in a society that not only abandoned its White Australia policy only a little over thirty years ago, but must also now grapple with the transnational nature of its citizenry, which includes African blacks? We use reflexive narratives to present a snapshot of our everyday experiences as black Africans, negotiating the multiple complex layerings of not just our blackness, but also our diasporic African existence. We address the challenges and contradictions of negotiating reified and homogenised black/African migrant/outsider labels and identities. In particular, we reflect on our endeavours to confront stereotypical and distorted interpretations that seek to identify and categorise our existence in terms of the problematised 'other': as the unknowing, uneducated, oppressed and dispossessed persons of colour. The ensuing analysis is not intended as a theoretical discussion of race, racism or race relations in the wider Australian context. Rather, these are 'our tales of blackness,' of the dilemmas of negotiating subjectivity, of the multiple and paradoxical ways of being 'other' in a society that claims to be multicultural and is hailed as such worldwide.