Miracle-dz/UniFAR-FTUs huggingface dataset:
Multibeam echosounder observations reveal interactions between Antarctic krill and air-breathing predators

A multibeam echosounder (MBE) was deployed on an inflatable boat (length = 5.5 m) to observe swarms of Antarctic krill Euphausia superba in the nearshore environment off Livingston Island, South Shetland Islands, Antarctica. Visual observations of air-breathing predators, including penguins and fur seals, were made from the boat at the same time. MBEs extend the 2-dimensional acoustic observations that can be made with conventional vertical echosounders to 3 dimensions, enabling direct observation of the surface areas and volumes of entire krill swarms. Krill swarms exhibited a wide range of various size metrics (e.g. height, length and width) but only a narrow range of surface-area-to-volume ratios or 'roughnesses', suggesting that krill adopt a consistent group behavior to maintain swarm shape. The variation in R was investigated using generalized additive models (GAMs). GAMs indicated that the presence of air-breathing predators influenced swarm shape (R decreased as the range to predators decreased, and the swarms became more spherical), as did swarm nearest-neighbor distance (R decreased with increasing distance) and swarm position in the water column (R decreased in the upper 70% of the water column). Therefore, swarm shape appears to be influenced by a combination of behavioral responses to predator presence and environ- mental variables. MBEs have the potential to contribute much to studies of krill, and can provide data to improve our understanding of the behavior of krill in situ.
Edinburgh Research Explorer Understanding factors affecting patient and public engagement and recruitment to digital health interventions

Background: Numerous types of digital health interventions (DHIs) are available to patients and the public but many factors affect their ability to engage and enrol in them. This systematic review aims to identify and synthesise the qualitative literature on barriers and facilitators to engagement and recruitment to DHIs to inform future implementation efforts. Methods: PubMed, MEDLINE, CINAHL, Embase, Scopus and the ACM Digital Library were searched for English language qualitative studies from 2000 – 2015 that discussed factors affecting engagement and enrolment in a range of DHIs (e.g. ‘ telemedicine ’ , ‘ mobile applications ’ , ‘ personal health record ’ , ‘ social networking ’ ). Text mining and additional search strategies were used to identify 1,448 records. Two reviewers independently carried out paper screening, quality assessment, data extraction and analysis. Data was analysed using framework synthesis, informed by Normalization Process Theory, and Burden of Treatment Theory helped conceptualise the interpretation of results. Results: Nineteen publications were included in the review. Four overarching themes that affect patient and public engagement and enrolment in DHIs emerged; 1) personal agency and motivation; 2) personal life and values; 3) the engagement and recruitment approach; and 4) the quality of the DHI. The review also summarises engagement and recruitment strategies used. A preliminary DI gital Health E n G agement MOdel (DIEGO) was developed to highlight the key processes involved. Existing knowledge gaps are identified and a number of recommendations made for future research. Study limitations include English language publications and exclusion of grey literature. Conclusion: This review summarises and highlights the complexity of digital health engagement and recruitment processes and outlines issues that need to be addressed before patients and the public commit to digital health and it can be implemented effectively. More work is needed to create successful engagement strategies and better quality digital solutions that are personalised where possible and to gain clinical accreditation and endorsement when appropriate. More investment is also needed to improve computer literacy and ensure technologies are accessible and affordable for those who wish to sign up to them. CRD42015029846
A Preliminary Study of Quantitative Protocols in Indium 111 SPECT Using Computational Simulations and Phantoms

Indium 111 SPECT allows one to determine the activity distribution of tracers used in radioimmunotherapy, such as Zevalin® labeled with yttrium 90. Using computer simulations and phantom models, we assessed various processing schemes to identify a clinically feasible protocol to estimate the tracer concentrations from 111ln SPECT images. The SPECT acquisition of a cylindrical phantom containing spheres was simulated. Several processing protocols that all included corrections for scatter, attenuation, and partial volume effect were compared using the simulated data. The protocol yielding the most accurate estimates of activity concentrations in the spheres was identified. This protocol was then applied to the experimental SPECT acquisitions of the cylindrical phantom and of an anthropomorphic phantom. Using the experimental data, the impact of the delineation and location of the volumes of interest (VOI) used for the measurements was also studied. The algorithm yielding the most accurate activity estimates included a dual energy window scatter subtraction, nonuniform attenuation correction in OSEM, and partial volume effect correction using recovery coefficients. With this protocol, errors in activity estimates were less than 9 % in spheres greater than 15 mm in diameter for the simulated and the experimental data of the cylindrical phantom. Realistic errors in volume delineation increased the errors in activity estimates up to 23% for these spheres. Using the anthropomorphic phantom, errors in activity estimates using realistic VOI were less than 20% in all organs and tumors. Appropriate processing of 111ln SPECT images yielded clinically useful activity estimates that were accurate within ±20%. It is therefore possible to use these activity values as an input for radiation-absorbed dose calculations in targeted radiotherapy.
Emotions as Within or Between People? Cultural Variation in Lay Theories of Emotion Expression and Inference

Four studies using open-ended and experimental methods test the hypothesis that in Japanese contexts, emotions are understood as between people, whereas in American contexts, emotions are understood as primarily within people. Study 1 analyzed television interviews of Olympic athletes. When asked about their relationships, Japanese athletes used significantly more emotion words than American athletes. This difference was not significant when questions asked directly about athletes' feelings. In Study 2, when describing an athlete's emotional reaction to winning, Japanese participants implicated others more often than American participants. After reading an athlete's self-description, Japanese participants inferred more emotions when the athlete mentioned relationships, whereas American participants inferred more emotions when the athlete focused only on herself (Study 3). Finally, when viewing images of athletes, Japanese participants inferred more emotions for athletes pictured with teammates, whereas American participants inferred more emotions for athletes pictured alone (Studies 4a and 4b).
Interdecadal changes in mesoscale eddy variance in the Gulf of Alaska circulation: Possible implications for the Steller sea lion decline

Abstract A distinct change in the ocean circulation of the Gulf of Alaska after the 1976–77 climate shift is studied in an eddy‐permitting primitive equation model forced by observed wind stresses from 1951–99. When the Aleutian Low strengthens after 1976–77, strong changes occur in the mean velocity of the Alaskan Stream and in its associated mesoscale eddy field. In contrast, the Alaska Current and the eddy flows in the eastern Gulf remain relatively unchanged after the shift. Since mesoscale eddies provide a possible mechanism for transporting nutrient‐ rich open‐ocean waters to the productive shelf region, the flow of energy through the food web may have been altered by this physical oceanographic change. This climate‐driven mechanism, which has a characteristic eastwest spatial asymmetry, may potentially help to explain changes in forage fish quality in diet diversity of Steller sea lions whose populations have declined precipitously since the mid‐1970s in the western Gulf while remaining stable in the eastern Gulf.
Melatonin rhythms in renal transplant recipients with sleep–wake disturbances

ABSTRACT We assessed salivary melatonin levels in renal transplant (RTx) recipients who participated in a randomised, multicentre wait-list controlled trial on the effect of bright light therapy on their sleep and circadian rhythms. A large proportion of RTx recipients in our cohort had unexpectedly low melatonin values, which precluded calculation of the dim-light melatonin onset (DLMO) as a circadian marker. Thus, the aim of this post hoc analysis was to describe the melatonin profile of home-dwelling RTx recipients diagnosed with sleep–wake disturbances (SWDs). The participants were characterised by means of sleep questionnaires, validated psychometric instruments [Pittsburgh sleep quality Index (PSQI), Epworth sleepiness scale (ESS), Morningness-Eveningness Questionnaire (MEQ) and Depression, Anxiety and Stress Scale (DASS)] in addition to melatonin assay in saliva. Data were analysed with descriptive statistics and group comparisons made with appropriate post hoc tests. RTx recipients [n = 29 (aged 54.83 ± 13.73, transplanted 10.62 ± 6.84 years ago)] were retrospectively grouped into two groups: RTx recipients whose dim light melatonin onset (DLMO) could be calculated (n = 11) and those whose DLMO could not be calculated (n = 18). RTx recipients having a measurable DLMO had a number of differences from those without DLMO: they were younger [46.4 ± 14.9 compared to 60.0 ± 10.3 (p = .007)], had higher haemoglobin values [135.36 ± 12.01 versus 122.82 ± 11.56 (p = .01)], less anxiety [4 (0;8) versus 12 (6.5;14) (p = .021)] and a better overall sense of coherence [SOC Score: 71.09 ± 12.78 versus 56.28 ± 15.48 (p = 0.013)]. These results suggest that RTx recipients whose DLMO could be calculated have less health impairments, underlying the relevance of a stable circadian system.
Successful Aging: A Life-Course Perspective on Women's Multiple Roles and Health

Panel data from a sample of 313 women who were wives and mothers in 1956 and were interviewed both in 1956 and in 1986 are used to consider the pathways that lead to health and social integration. Possible relationships were explored between the number, duration, timing, and episodes of various nonfamily roles throughout adult-hood and subsequent health and multiple-role occupancy. It was found that occupying multiple roles in 1956, participating in volunteer work on an intermittent basis, and belonging to a club or organization were positively related to various measures of health and that occupying multiple roles in 1956, as well as doing volunteer work, was positively related to occupying multiple roles in 1986.
The Five-Year Clinical and Angiographic Follow-Up Outcomes of Intracoronary Transfusion of Circulation-Derived CD34+ Cells for Patients With End-Stage Diffuse Coronary Artery Disease Unsuitable for Coronary Intervention—Phase I Clinical Trial

Objectives: This study investigated the clinical and angiographic long-term outcomes of intracoronary transfusion of circulation-derived CD34+ cells for patients with end-stage diffuse coronary artery disease unsuitable for coronary intervention. Design and Setting: A single-center prospective randomized double-blinded phase I clinical trial. Thirty-eight patients undergoing CD34+ cell therapy were allocated into groups 1 (1.0 × 107 cells/each vessel; n = 18) and 2 (3.0 × 107 cells/each vessel; n = 20). Patients: Those with end-stage diffuse coronary artery disease were unsuitable for percutaneous and surgical coronary revascularization. Interventions: Intracoronary delivery of circulation-derived CD34+ cells. Measurements and Main Results: We prospectively evaluated long-term clinical and echocardiographic/angiographic outcomes between survivors and nonsurvivors. By the end of 5-year follow-up, the survival rate and major adverse cardio/cerebrovascular event were 78.9% (30/38) and 36.8% (14/38), respectively. During follow-up period, 31.6% patients (12/38) received coronary stenting for reason of sufficient target vessel size grown-up after the treatment. Endothelial function was significantly reduced in the nonsurvivors than the survivors (p = 0.039). Wimasis image analysis of angiographic findings showed that the angiogenesis was significantly and progressively increased from baseline to 1 and 5 years (all p < 0.001). The 3D echocardiography showed left ventricular ejection fraction increased from baseline to 1 year and then remained stable up to 5 years, whereas left ventricular chamber diameter exhibited an opposite pattern to left ventricular ejection fraction among the survivors. The clinical scores for angina and heart failure were significantly progressively reduced from baseline to 1 and 5 years (all p < 0.001). Conclusions: CD34+ cell therapy for end-stage diffuse coronary artery disease patients might contribute to persistently long-term effects on improvement of left ventricular function, angina/heart failure, and amelioration of left ventricular remodeling.
The influence of cell micro-structure on the in-plane dynamic crushing of honeycombs with negative Poisson’s ratio

The in-plane dynamic crushing behaviors and energy-absorbed characteristics of honeycombs with negative Poisson’s ratio (NPR) have been studied by means of explicit dynamic finite element analysis (DFEA) using ANSYS/LS-DYNA. First, the honeycomb models filled with different reentrant cells by the variation of micro-cell configuration parameters (cell-wall angle and shape ratio) are established. The respective influences of micro-structure and impact velocities on the deformation behaviors, the dynamic plateau stresses and the absorbed energy of reentrant honeycombs are explored in detail. It is shown that owing to the variation of cell micro-structure, reentrant honeycombs display different macro-/micro- deformation properties during the crushing. For the given impact velocity, the dynamic plateau stresses are related to the shape ratio by a power law and to the cell-wall angle by least-square curves. And they are also proportional to the square of impact velocities for a high impact velocity. Based on the finite element simulated results and one-dimensional shock wave theory, an empirical formula for auxetic honeycomb to predict the dynamic plateau stress is derived in terms of relative density and impact velocity.
Effects of pond water, sediment and sediment extract samples from new hampshire, usa on early Xenopus development and metamorphosis: comparison to native species

In an effort to assess potential ecological hazards to amphibian species in selected regions within New Hampshire, the traditional Frog Embryo Teratogenesis Assay—Xenopus (FETAX), a 14‐/21 day tail resorption thyroid disruption assay and >30 day limb development tests were conducted with representative surface water and sediment samples. Two separate sets of samples collected from five sites were evaluated. The primary objectives of the study were to determine if samples were capable of inducing early embryo‐larval maldevelopment, to determine if maldevelopment included limb defects, to determine if thyroxine co‐administration altered the rates of limb malformation and to evaluate the impact of the samples on growth rates, developmental progress and metamorphic climax. Results from these studies suggested that pond water and sediment extract samples, but not whole sediment samples, from B2, FW, LP and W ponds were capable of inducing abnormal early embryo‐larval development. In addition, water samples from B2 and W ponds induced significant abnormal hindlimb development. Some abnormal forelimb development was noted in the tail resorption studies, but not to the same extent as the hindlimbs. Each of the water samples induced appreciable developmental delay, including the paired reference site B1, which could be reversed by the addition of exogenous thyroxine. Copyright © 2001 John Wiley & Sons, Ltd.
Prediction of Forest Canopy and Surface Fuels from Lidar and Satellite Time Series Data in a Bark Beetle-Affected Forest

Wildfire behavior depends on the type, quantity, and condition of fuels, and the effect that bark beetle outbreaks have on fuels is a topic of current research and debate. Remote sensing can provide estimates of fuels across landscapes, although few studies have estimated surface fuels from remote sensing data. Here we predicted and mapped field-measured canopy and surface fuels from light detection and ranging (lidar) and Landsat time series explanatory variables via random forest (RF) modeling across a coniferous montane forest in Colorado, USA, which was affected by mountain pine beetles (Dendroctonus ponderosae Hopkins) approximately six years prior. We examined relationships between mapped fuels and the severity of tree mortality with correlation tests. RF models explained 59%, 48%, 35%, and 70% of the variation in available canopy fuel, canopy bulk density, canopy base height, and canopy height, respectively (percent root-mean-square error (%RMSE) = 12–54%). Surface fuels were predicted less accurately, with models explaining 24%, 28%, 32%, and 30% of the variation in litter and duff, 1 to 100-h, 1000-h, and total surface fuels, respectively (%RMSE = 37–98%). Fuel metrics were negatively correlated with the severity of tree mortality, except canopy base height, which increased with greater tree mortality. Our results showed how bark beetle-caused tree mortality significantly reduced canopy fuels in our study area. We demonstrated that lidar and Landsat time series data contain substantial information about canopy and surface fuels and can be used for large-scale efforts to monitor and map fuel loads for fire behavior modeling at a landscape scale.
Relationship of High-Sensitivity C-Reactive Protein Concentrations and Systolic Heart Failure.

OBJECTIVE Excessive activated proinflammatory cytokines may promote extracellular matrix alterations which induce adverse left ventricular remodeling in systolic heart failure (SHF). We sought to identify whether high-sensitivity C-reactive protein (hsCRP) levels were independently associated with SHF. METHODS In our retrospective case-control study, 2236 subjects were included, and 260 patients had SHF. Blood sample collection, clinical laboratory tests, electrocardiogram and echocardiography examinations were performed. The questionnaires were completed by professional interviews. RESULTS In 2236 subjects, the prevalence rate of SHF were 1.7, 1.8, 8.4 and 32.6% between hsCRP concentrations (<1 mg/L, ≥1 to <3 mg/L, ≥3 to <10 mg/L and ≥10 mg/L, respectively) (p=0.000). hsCRP concentrations (<1 mg/L, ≥1 to <3 mg/L, ≥3 to <10 mg/L and ≥10 mg/L) were associated in a linear trend with N-terminal pro-brain natriuretic peptide (NT-proBNP, p=0.000) and left ventricular ejection fraction (LVEF, p=0.000). hsCRP was also significantly related to NT-proBNP, LVEF and SHF (r=0.232, p=0.000; r=-0.358, p=0.000 and r=0.413, p=0.000, respectively). In logistic regression model, after adjusting for heart failure risk factors, compared with the low concentration of hsCRP (<1 mg/L), the high concentration of hsCRP (≥10 mg/L) was significantly independently associated with SHF (odds ratio = 10.78 [1.303 to 89.10], p=0.027). CONCLUSION Low to high concentration of hsCRP showed a linear trend association with SHF. A high concentration of hsCRP was independently associated with SHF.
Ventilatory Support in Children With Pediatric Acute Respiratory Distress Syndrome: Proceedings From the Pediatric Acute Lung Injury Consensus Conference

Objective: To describe the recommendations of the Pediatric Acute Lung Injury Consensus Conference for mechanical ventilation management of pediatric patients with acute respiratory distress syndrome. Design: Consensus Conference of experts in pediatric acute lung injury. Methods: The Pediatric Acute Lung Injury Consensus Conference experts developed and voted on a total of 27 recommendations focused on the optimal mechanical ventilation approach of the patient with pediatric acute respiratory distress syndrome. Topics included ventilator mode, tidal volume delivery, inspiratory plateau pressure, high-frequency ventilation, cuffed endotracheal tubes, and gas exchange goals. When experimental data were lacking, a modified Delphi approach emphasizing the strong professional agreement was used. Results: There were 17 recommendations with strong agreement and 10 recommendations with weak agreement. There were no recommendations with equipoise or disagreement. There was weak agreement on recommendations concerning approach to tidal volume and inspiratory pressure limitation (88% to 72% agreement, respectively), whereas strong agreement could be achieved for accepting permissive hypercapnia. Using positive end-expiratory pressure levels greater than 15 cm H2O in severe pediatric acute respiratory distress syndrome, under the condition that the markers of oxygen delivery, respiratory system compliance, and hemodynamics are closely monitored as positive end-expiratory pressure is increased, is strongly recommended. The concept of exploring the effects of careful recruitment maneuvers during conventional ventilation met an agreement level of 88%, whereas the use of recruitment maneuvers during rescue high-frequency oscillatory ventilation is highly recommended (strong agreement). Conclusions: The Consensus Conference developed pediatric-specific recommendations regarding mechanical ventilation of the patient with pediatric acute respiratory distress syndrome as well as future research priorities. These recommendations are intended to initiate discussion regarding optimal mechanical ventilation management for children with pediatric acute respiratory distress syndrome and identify areas of controversy requiring further investigation.
Validation of remotely sensed profiles of atmospheric state variables: strategies and terminology

This paper summarizes and classifies the various approaches to validation of remote measurements of atmospheric state variables, and tries to recommend a clear and unambiguous terminology. The following approaches have been identified: Intercomparison of individual profiles for accuracy validation; statistical comparison of matched pairs of measurements with respect to bias determination and precision validation; statistical intercomparison of randomly sampled measurements by two instruments, and comparison of a single measurement to an ensemble of measurements. Applicable statistics are shortly reviewed, and recipes for evaluation of the co-incidence error due to less than perfect co-incidences are presented. An approach is suggested to quantitatively validate profile measurements when full covariance matrices are unavailable.
Maritime aerosol network as a component of AERONET - first results and comparison with global aerosol models and satellite retrievals

Abstract. The Maritime Aerosol Network (MAN) has been collecting data over the oceans since November 2006. Over 80 cruises were completed through early 2010 with deployments continuing. Measurement areas included various parts of the Atlantic Ocean, the Northern and Southern Pacific Ocean, the South Indian Ocean, the Southern Ocean, the Arctic Ocean and inland seas. MAN deploys Microtops hand-held sunphotometers and utilizes a calibration procedure and data processing traceable to AERONET. Data collection included areas that previously had no aerosol optical depth (AOD) coverage at all, particularly vast areas of the Southern Ocean. The MAN data archive provides a valuable resource for aerosol studies in maritime environments. In the current paper we present results of AOD measurements over the oceans, and make a comparison with satellite AOD retrievals and model simulations.