Miracle-dz/UniFAR-FTUs huggingface dataset:
Cooperative regions and partner choice in coded Cooperative systems

User cooperation is an efficient approach to obtain diversity in both centralized and distributed wireless networks. In this paper, we consider a coded cooperative system under quasi-static Rayleigh fading and investigate the partner-choice problem. We find conditions on the interuser and user-to-destination channel qualities for cooperation to be beneficial. Using frame-error rate as a metric, we define the user cooperation gain (G) for evaluating the relative performance improvement of cooperative over direct transmission when a particular channel code is used. We introduce the cooperation decision parameter (CDP), which is a function of user-to-destination average received signal-to-noise ratios (SNRs), and demonstrate that whether cooperation is useful or not (G>1 or G<1) depends only on the CDP, not the interuser link quality. We use an analytical formulation of the CDP to investigate user cooperation gain and provide insights on how a user can choose among possible partners to maximize cooperation gain. We first consider the asymptotic performance when one or both partners have high average received SNR at the destination. We then provide conditions on user and destination locations for cooperation to be beneficial for arbitrary SNRs. We illustrate these cooperative regions, and study geometric conditions for the best partner choice. We also define the system cooperation gain and illustrate cooperation benefits for both users. All of our theoretical results are verified through numerical examples
Stop Saying That It Is Wrong! Psychophysiological, Cognitive, and Metacognitive Markers of Children’s Sensitivity to Punishment

Neurodevelopmental evidence suggests that children’s main decision-making strategy is to avoid options likely to induce punishment. However, the cognitive and affective factors contributing to children’s avoidance to high punishment frequency remain unknown. The present study explored psychophysiological, cognitive, and metacognitive processes associated with sensitivity to punishment frequency. We evaluated 54 participants (between 8 and 15 years old) with a modified Iowa Gambling Task for children (IGT-C) which included options with varying long-term profit and punishment frequencies. Skin conductance responses (SCRs) were recorded during this task. Additionally, we assessed IGT-C metacognitive knowledge, fluid intelligence, and executive functions. Participants exhibited behavioral avoidance and high anticipatory SCRs to options with high frequency of punishment. Moreover, age, IGT-C metacognitive knowledge, and inhibitory control were associated with individual differences in sensitivity to punishment frequency. Our results suggest that children’s preference for infrequently punished decisions is partially explained by psychophysiological signals as well as task complexity and development of cognitive control.
PROCUSTE1 Encodes a Cellulose Synthase Required for Normal Cell Elongation Specifically in Roots and Dark-Grown Hypocotyls of Arabidopsis

Mutants at the PROCUSTE1 (PRC1) locus show decreased cell elongation, specifically in roots and dark-grown hypocotyls. Cell elongation defects are correlated with a cellulose deficiency and the presence of gapped walls. Map-based cloning of PRC1 reveals that it encodes a member (CesA6) of the cellulose synthase catalytic subunit family, of which at least nine other members exist in Arabidopsis. Mutations in another family member, RSW1 (CesA1), cause similar cell wall defects in all cell types, including those in hypocotyls and roots, suggesting that cellulose synthesis in these organs requires the coordinated expression of at least two distinct cellulose synthase isoforms.
Smoking before pregnancy and risk of gestational hypertension and preeclampsia.

OBJECTIVE Our purpose was to determine whether smoking before pregnancy reduces the risk of gestational hypertension or preeclampsia. STUDY DESIGN The trial of Calcium for Preeclampsia Prevention (CPEP) was a randomized study of 4589 nulliparous women conducted in 5 US medical centers during the years 1992 through 1995. Women were classified into 4 exposure groups by smoking history obtained at study enrollment (13-21 weeks' gestation): (1) never smoked, (2) smoked but quit before the last menstrual period (LMP), (3) smoked but quit after LMP but before enrollment, and (4) smoked and still smoking at enrollment. RESULTS After adjustments were made for maternal age, race, body mass index, type of health insurance, and clinical center, women smoking at enrollment had a reduced risk of hypertension (relative risk = 0.8; 95% CI, 0.6-0.9). Women who quit smoking before the LMP did not have reduced risk (relative risk = 1.1; 95% CI, 0.9-1.3). Results were similar for gestational hypertension and preeclampsia examined separately. CONCLUSION Women who smoke but quit before becoming pregnant do not have a reduced risk for gestational hypertension or preeclampsia.
Volume kinetics of glucose solutions given by intravenous infusion.

Glucose solutions given by intravenous (i.v.) infusion exert volume effects that are governed by the amount of fluid administered and also by the metabolism of the glucose. To understand better how the body handles glucose solutions, two volume kinetic models were developed in which consideration was given to the osmotic fluid shifts that accompany the metabolism of glucose. These models were fitted to data obtained when 21 volunteers who were given approximately 1 litre of glucose 2.5 or 5% or Ringer's solution (control) over 45 min. The maximum haemodilution was similar for all three fluids, but it decreased more rapidly when glucose had been infused. The volume of distribution for the infused glucose molecules was larger (approximately 12 litres) than for the infused fluid, which amounted to (mean (SEM)) 3.7 (0.3) (glucose 2.5%), 2.8 (0.2) (glucose 5%), and 2.5 (0.2) litres (Ringer). Fluid accumulated in a remote (cellular) body fluid space when glucose had been administered (approximately 0.2 and 0.4 litres, respectively), while expansion of an intermediate fluid space (7.1 (1.3) litres) could be demonstrated in 33% of the Ringer experiments. In conclusion, kinetic models were developed which consider the relationship between the glucose metabolism and the disposition of intravenous fluid. One of them, in which infused fluid expands two instead of three body fluid spaces, was successfully fitted to data on blood glucose and blood haemoglobin obtained during infusions of 2.5 and 5% glucose.
NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism

Cytokines, such as tumor necrosis factor-α (TNFα), potently inhibit the differentiation of mesenchymal cells and down-regulate the expression of Sox9 and MyoD, transcription factors required for chondrocyte and myocyte development. Previously, we demonstrated that NF-κB controls TNFα-mediated suppression of myogenesis through a mechanism involving MyoD mRNA down-regulation. Here, we show that NF-κB also suppresses chondrogenesis and destabilizes Sox9 mRNA levels. Multiple copies of an mRNA cis-regulatory motif (5′-ACUACAG-3′) are necessary and sufficient for NF-κB-mediated Sox9 and MyoD down-regulation. Thus, in response to cytokine signaling, NF-κB modulates the differentiation of mesenchymal-derived cell lineages via RNA sequence-dependent, posttranscriptional down-regulation of key developmental regulators.
Fuzzy differential inclusions in atmospheric and medical cybernetics

Uncertainty management in dynamical systems is receiving attention in artificial intelligence, particularly in the fields of qualitative and model based reasoning. Fuzzy dynamical systems occupy a very important position in the class of uncertain systems. It is well established that the fuzzy dynamical systems represented by a set of fuzzy differential inclusions (FDI) are very convenient tools for modeling and simulation of various uncertain systems. In this paper, we discuss about the mathematical modeling of two very complex natural phenomena by means of FDIs. One of them belongs to the atmospheric cybernetics (the term has been used in a broad sense) of the genesis of a cyclonic storm (cyclogenesis), and the other belongs to the bio-medical cybernetics of the evolution of tumor in a human body. Since a discussion of the former already appears in a previous paper by the first author, here, we present very briefly a theoretical formalism of cyclone formation. On the other hand, we treat the latter system more elaborately. We solve the FDIs with the help of an algorithm developed in this paper to numerically simulate the mathematical models. From the simulation results thus obtained, we have drawn a number of interesting conclusions, which have been verified, and this vindicates the validity of our models.
Germline stem cell arrest inhibits the collapse of somatic proteostasis early in Caenorhabditis elegans adulthood

All cells rely on highly conserved protein folding and clearance pathways to detect and resolve protein damage and to maintain protein homeostasis (proteostasis). Because age is associated with an imbalance in proteostasis, there is a need to understand how protein folding is regulated in a multicellular organism that undergoes aging. We have observed that the ability of Caenorhabditis elegans to maintain proteostasis declines sharply following the onset of oocyte biomass production, suggesting that a restricted protein folding capacity may be linked to the onset of reproduction. To test this hypothesis, we monitored the effects of different sterile mutations on the maintenance of proteostasis in the soma of C. elegans. We found that germline stem cell (GSC) arrest rescued protein quality control, resulting in maintenance of robust proteostasis in different somatic tissues of adult animals. We further demonstrated that GSC‐dependent modulation of proteostasis requires several different signaling pathways, including hsf‐1 and daf‐16/kri‐1/tcer‐1, daf‐12, daf‐9, daf‐36, nhr‐80, and pha‐4 that differentially modulate somatic quality control functions, such that each signaling pathway affects different aspects of proteostasis and cannot functionally complement the other pathways. We propose that the effect of GSCs on the collapse of proteostasis at the transition to adulthood is due to a switch mechanism that links GSC status with maintenance of somatic proteostasis via regulation of the expression and function of different quality control machineries and cellular stress responses that progressively lead to a decline in the maintenance of proteostasis in adulthood, thereby linking reproduction to the maintenance of the soma.
Explaining and Predicting the Impact of Branding Alliances and Web Site Quality on Initial Consumer Trust of E-Commerce Web Sites

Trust is a crucial factor in e-commerce. However, consumers are less likely to trust unknown Web sites. This study explores how less-familiar e-commerce Web sites can use branding alliances and Web site quality to increase the likelihood of initial consumer trust. We use the associative network model of memory to explain brand knowledge and to show how the mere exposure effect can be leveraged to improve a Web site's brand image. We also extend information integration theory to explain how branding alliances are able to increase initial trust and transfer positive effects to Web sites. Testing of our model shows that the most important constructs for increasing initial trust in our experimental context are branding and Web site quality. Finally, we discuss future research ideas, limitations, implications, and ideas for practitioners.
Topography and numerical distribution of intracardiac ganglion cells in the cat

Serial sections stained with thionin and with phosphotungstic acid hematoxylin of a complete kitten heart and of portions of hearts from eight adult cats were studied to determine the location of intracardiac ganglion cells and to estimate their number. Ganglion cells were found in well defined anatomical relationships to the great vessels, the atria and the interatrial septum, but were never found below the coronary sulcus. Several distinct groups are described. The estimated total number of ganglion cells in an adult heart is 8405. Histological relationships between ganglion cell groups and nodal tissue, coronary arteries and myocardial tissue are described.
Killer Whale Depredation and Associated Costs to Alaskan Sablefish, Pacific Halibut and Greenland Turbot Longliners

Killer whale (Orcinus orca) depredation (whales stealing or damaging fish caught on fishing gear) adversely impacts demersal longline fisheries for sablefish (Anoplopoma fimbria), Pacific halibut (Hippoglossus stenolepis) and Greenland turbot (Reinhardtius hippoglossoides) in the Bering Sea, Aleutian Islands and Western Gulf of Alaska. These interactions increase direct costs and opportunity costs associated with catching fish and reduce the profitability of longline fishing in western Alaska. This study synthesizes National Marine Fisheries Service observer data, National Marine Fisheries Service sablefish longline survey and fishermen-collected depredation data to: 1) estimate the frequency of killer whale depredation on longline fisheries in Alaska; 2) estimate depredation-related catch per unit effort reductions; and 3) assess direct costs and opportunity costs incurred by longliners in western Alaska as a result of killer whale interactions. The percentage of commercial fishery sets affected by killer whales was highest in the Bering Sea fisheries for: sablefish (21.4%), Greenland turbot (9.9%), and Pacific halibut (6.9%). Average catch per unit effort reductions on depredated sets ranged from 35.1–69.3% for the observed longline fleet in all three management areas from 1998–2012 (p<0.001). To compensate for depredation, fishermen set additional gear to catch the same amount of fish, and this increased fuel costs by an additional 82% per depredated set (average $433 additional fuel per depredated set). In a separate analysis with six longline vessels in 2011and 2012, killer whale depredation avoidance measures resulted in an average additional cost of $494 per depredated vessel-day for fuel and crew food. Opportunity costs of time lost by fishermen averaged $522 per additional vessel-day on the grounds. This assessment of killer whale depredation costs represents the most extensive economic evaluation of this issue in Alaska to date and will help longline fishermen and managers consider the costs and benefits of depredation avoidance and alternative policy solutions.
Crystal structure, phase stability, and magnetism in Ni3V.

The structural phase stability and magnetism of Ni/sub 3/V are investigated using an all-electron total-energy local-(spin)-density approach for its cubic (L1/sub 2/), tetragonal (DO/sub 22/), and hexagonal (DO/sub 19/) crystal structures. In agreement with experiment, the paramagnetic DO/sub 22/ structure is found to be the most stable phase. The L1/sub 2/ structure shows a ferromagnetic instability with a magnetic moment of 1 . mu. /sub B/ per formula unit. An important role is found for the second-neighbor d-d coupling in determining the electronic structure and the observed crystal structure.
A key role for lipoic acid synthesis during Plasmodium liver stage development

The successful navigation of malaria parasites through their life cycle, which alternates between vertebrate hosts and mosquito vectors, requires a complex interplay of metabolite synthesis and salvage pathways. Using the rodent parasite Plasmodium berghei, we have explored the synthesis and scavenging pathways for lipoic acid, a short‐chain fatty acid derivative that regulates the activity of α‐ketoacid dehydrogenases including pyruvate dehydrogenase. In Plasmodium, lipoic acid is either synthesized de novo in the apicoplast or is scavenged from the host into the mitochondrion. Our data show that sporozoites lacking the apicoplast lipoic acid protein ligase LipB are markedly attenuated in their infectivity for mice, and in vitro studies document a very late liver stage arrest shortly before the final phase of intra‐hepaticparasite maturation. LipB‐deficient asexual blood stage parasites show unimpaired rates of growth in normal in vitro or in vivo conditions. However, these parasites showed reduced growth in lipid‐restricted conditions induced by treatment with the lipoic acid analogue 8‐bromo‐octanoate or with the lipid‐reducing agent clofibrate. This finding has implications for understanding Plasmodium pathogenesis in malnourished children that bear the brunt of malarial disease. This study also highlights the potential of exploiting lipid metabolism pathways for the design of genetically attenuated sporozoite vaccines.
CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation

Antigen-induced immune suppression, like T cell activation, requires antigen-presenting cells (APCs); however, the role of APCs in mediating these opposing effects is not well understood, especially in vivo. We report that genetic inactivation of CD11b, which is a CD18 subfamily of integrin receptors that is highly expressed on APCs, abolishes orally induced peripheral immune tolerance (oral tolerance) without compromising APC maturation or antigen-specific immune activation. The defective oral tolerance in CD11b−/− mice can be restored by adoptive transfer of wild-type APCs. CD11b deficiency leads to enhanced interleukin (IL) 6 production by APCs, which subsequently promotes preferential differentiation of naive T cells to T helper 17 (Th17) cells, which are a T cell lineage characterized by their production of IL-17. Consequently, antigen feeding and immunization of CD11b−/− mice results in significant production of IL-17 within the draining lymph nodes that interferes with the establishment of oral tolerance. Together, we conclude that CD11b facilitates oral tolerance by suppressing Th17 immune differentiation.
Rupture Kinematics of the 2005 Mw 8.6 Nias-Simeulue Earthquake from the Joint Inversion of Seismic and Geodetic Data

The 2005 Mw 8.6 Nias-Simeulue earthquake was caused by rupture of a portion of the Sunda megathrust offshore northern Sumatra. This event occurred within an array of continuous Global Positioning System (GPS) stations and produced measurable vertical displacement of the fringing coral reefs above the fault rupture. Thus, this earthquake provides a unique opportunity to assess the source character- istics of a megathrust event from the joint analysis of seismic data and near-field static co-seismic displacements. Based on the excitation of the normal mode data and geodetic data we put relatively tight constraints on the seismic moment and the fault dip, where the dip is determined to be 8� to 10� with corresponding moments of 1.24 10 22 to 1.00 10 22 N m, respectively. The geodetic constraints on slip distribution help to eliminate the trade-off between rupture velocity and slip kine- matics. Source models obtained from the inversion of various combinations of the teleseismic body waves and geodetic data are evaluated by comparing predicted and observed long-period seismic waveforms (100-500 sec). Our results indicate a rela- tively slow average rupture velocity of 1.5 to 2.5 km/sec and long average rise time of up to 20 sec. The earthquake nucleated between two separate slip patches, one beneath Nias and the other beneath Simeulue Island. The gap between the two patches and the hypocentral location appears to be coincident with a local geological disrup- tion of the forearc. Coseismic slip clearly tapers to zero before it reaches the trench probably because the rupture propagation was inhibited when it reached the accre- tionary prism. Using the models from joint inversions, we estimate the peak ground velocity on Nias Island to be about 30 cm/sec, an order of magnitude slower than for thrust events in continental areas. This study emphasizes the importance of util- izing multiple datasets in imaging seismic ruptures.
Mitral valve repair: better than replacement

For the majority of surgeons, mitral valve repair has become the method of choice for surgical correction of mitral regurgitation. However, the feasibility of repair depends not only on the pathology but also on the experience of the surgeon and/or team. Success rates may reach almost 100% in the most common form of isolated prolapse of the middle scallop of the posterior leaflet. Nevertheless, mitral repair is still subject to a pronounced, sometimes painful, learning curve. The durability of the repair also depends on the type of pathology and on many other factors, including the technique used. Since its inception in the 1970s, the techniques of mitral valve repair have been the subject of many modifications and improvements which have made it a more predictable and reproducible method. One area where much improvement was made was ischaemic regurgitation, which was initially considered refractory to repair and for which there is now a growing experience and much improved results. Also, advancements have occurred in the treatment of regurgitation related to cardiomyopathy, previously considered a contraindication for repair. By contrast, repair for rheumatic disease still carries the worst results, although the characteristics of the usually underdeveloped and young population may still make it preferable to mitral valve replacement. In this work, we analyse the state of the art of mitral valve repair and its results according to our experience and in the light of recent reports. After an initial period of distrust, in the late 1970s and early 1980s, when it was developed mainly through the efforts of Carpentier,1 Duran,2 and others, mitral valve repair has since become a generally accepted alternative to prosthetic replacement for surgical treatment of virtually all forms of mitral valve disease; indeed, most surgeons now recognise its superiority, in terms of both early and late …
Discontinuous deformation analysis framework for modelling concrete fracture

Some possibilities and limitations of the discontinuous deformation analysis in modelling concrete fracture are illustrated on several simple case studies, in particular in tracing the transition from a continuum to discontinuum. Computational issues involved are briefly reviewed and the recent trend in recasting the original formulation in its more general form as a manifold method is noted. Illustrative examples include the Kitoh plain concrete beam and the RILEM pull-out benchmark problem.
Is the Effect of Aerobic Exercise on Cognition a Placebo Effect?

A number of studies and meta-analyses conclude that aerobic fitness (walking) interventions improve cognition. Such interventions typically compare improvements from these interventions to an active control group in which participants engage in non-aerobic activities (typically stretching and toning) for an equivalent amount of time. However, in the absence of a double-blind design, the presence of an active control group does not necessarily control for placebo effects; participants might expect different amounts of improvement for the treatment and control interventions [1]. We conducted a large survey to explore whether people expect greater cognitive benefits from an aerobic exercise intervention compared to a control intervention. If participants expect greater improvement following aerobic exercise, then the benefits of such interventions might be due in part to a placebo effect. In general, expectations did not differ between aerobic and non-aerobic interventions. If anything, some of the results suggest the opposite (e.g., respondents expected the control, non-aerobic intervention to yield bigger memory gains). These results provide the first evidence that cognitive improvements following aerobic fitness training are not due to differential expectations.