Miracle-dz/UniFAR-FTUs huggingface dataset:
Prediction of intention to continue sport in athlete students: A self-determination theory approach

Grounded on the self-determination theory (Deci & Ryan, 1985, 2000) and achievement goals theory (Ames, 1992; Nicholls, 1989), this study via structural equation modelling, predicted intention to continue in sport from goal orientations and motivations among athlete students. 268 athlete students (Mage = 21.9), in Iranian universities completed a multi-section questionnaire tapping the targeted variables. Structural equation modelling (SEM) offered an overall support for the proposed model. The results showed that there are positive relationships between intention to continue in sport and both orientations as well as both motivations. A task-involving orientation emerged as a positive predictor of the autonomous motivation, while an ego-involving orientation was a positive predictor controlled motivation as well as autonomous motivation. The results also support positive paths between autonomous motivation and future intention to participate in sport. Autonomous motivation also was a positive mediator in relationship between task orientation and the intentions. As a conclusion, the implications of the task-involving orientation are discussabled in the light of its importance for the quality and potential maintenance of sport involvement among athlete students.
New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes

ABSTRACT Cytoplasmic FMRP interacting protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID), autism, schizophrenia and epilepsy. It is a member of a family of proteins that is highly conserved during evolution, sharing high homology with its Drosophila homolog, dCYFIP. CYFIP1 interacts with the Fragile X mental retardation protein (FMRP, encoded by the FMR1 gene), whose absence causes Fragile X syndrome, and with the translation initiation factor eIF4E. It is a member of the WAVE regulatory complex (WRC), thus representing a link between translational regulation and the actin cytoskeleton. Here, we present data showing a correlation between mRNA levels of CYFIP1 and other members of the WRC. This suggests a tight regulation of the levels of the WRC members, not only by post-translational mechanisms, as previously hypothesized. Moreover, we studied the impact of loss of function of both CYFIP1 and FMRP on neuronal growth and differentiation in two animal models – fly and mouse. We show that these two proteins antagonize each other's function not only during neuromuscular junction growth in the fly but also during new neuronal differentiation in the olfactory bulb of adult mice. Mechanistically, FMRP and CYFIP1 modulate mTor signaling in an antagonistic manner, likely via independent pathways, supporting the results obtained in mouse as well as in fly at the morphological level. Collectively, our results illustrate a new model to explain the cellular roles of FMRP and CYFIP1 and the molecular significance of their interaction. Summary: CYFIP1 and FMRP interact antagonistically during neuromuscular junction growth in the fly and during new neuron differentiation in the olfactory bulb of the adult mouse.
Achieving linear scaling with interference alignment

Recent results have shown that interference alignment can achieve K/2 degrees of freedom in a K-user interference channel with time or frequency varying channel coefficients. For fixed number of users K, the number of degrees of freedom characterizes the asymptotic behavior of the performance in the high SNR limit but it does not answer the question of how the performance scales with K for any fixed SNR. In particular, it is unclear if a constant rate per user can be maintained as more users enter into the system. In this paper, we investigate the performance of the interference alignment scheme proposed in [5] for fixed SNR. We assume that the channel coefficients between the users are of the form r ejθ where r is fixed over the duration of communication and θ is a fast fading phase. We show that for any value of the SNR and K, the aggregate rate achieved by the interference alignment scheme of [5] is lower bounded by c1K log(1 + c2 SNR) where c1 and c2 are positive constants independent of both SNR and K. This result establishes the linear scaling of the interference alignment scheme for the considered random phase channel model.
Outbursts from IGR J17473-2721

Aims. IGR J17473-2721 was discovered by INTEGRAL as a neutron star low mass X-ray binary. To date, two outbursts have been detected in X-rays by RXTE/ASM and SWIFT: the one occurring in 2005 was weak and was characterized by a low/hard state spectrum; the one of March 2008 was strong and showed a 6-step evolution in its flux. We investigate their evolution, emphasizing the later outburst. Methods. We analyzed all available observations carried out by RXTE on IGR J17473-2721 during its later outburst. We analyzed as well all the available SWIFT/BAT data on this source. Results. The flux of the latter outburst rose in similar to one month and then kept roughly constant for the following similar to two months. During this time period, the source was in a low/hard state. The source moved to a high/soft state within the following three days, accompanied by the occurrence of an additional outburst at soft X-rays and the end of the preceding outburst in hard X-rays. During the decay of this soft outburst, the source went back to a low/hard state within 6 days, with a luminosity 4 times lower than the first transition. This shows a full cycle of the hysteresis in transition between the hard and the soft states. The fact that the flux remained roughly constant for similar to two months at times prior to the spectral transition to a high/soft state might be regarded as the result of balancing the evaporation of the inner disk and the inward accretion flow, in a model in which the state transition is determined by the mass flow rate. Such a balance might be broken via an additional mass flow accreting onto the inner disk, which lightens the extra soft outburst and causes the state transition. However, the possibility of an origin of the emission from the jet during this time period cannot be excluded. The spectral analysis suggests an inclined XRB system for IGR J17473-2721. Such a long-lived preceding low/hard state makes IGR J17473-2721 resemble the behavior of outbursts seen in black hole X-ray binaries like GX 339-4.
Distributed under Creative Commons Cc-by 4.0 a New Method for Ecoacoustics? toward the Extraction and Evaluation of Ecologically-meaningful Soundscape Components Using Sparse Coding Methods

Passive acoustic monitoring is emerging as a promising non-invasive proxy for ecological complexity with potential as a tool for remote assessment and monitoring (Sueur & Farina, 2015). Rather than attempting to recognise species-specific calls, either manually or automatically, there is a growing interest in evaluating the global acoustic environment. Positioned within the conceptual framework of ecoacoustics, a growing number of indices have been proposed which aim to capture community-level dynamics by (e. by providing statistical summaries of the frequency or time domain signal. Although promising, the ecological relevance and efficacy as a monitoring tool of these indices is still unclear. In this paper we suggest that by virtue of operating in the time or frequency domain, existing indices are limited in their ability to access key structural information in the spectro-temporal domain. Alternative methods in which time-frequency dynamics are preserved are considered. Sparse-coding and source separation algorithms (specifically, shift-invariant probabilistic latent component analysis in 2D) are proposed as a means to access and summarise time-frequency dynamics which may be more ecologically-meaningful.
Determination of Dynamic Material Properties of Silicone Rubber Using One-Point Measurements and Finite Element Simulations

The dynamic Young's modulus, Poisson's ratio, and the damping factor of silicone rubber are determined from a laser triangulation measurement of the top surface motion of a flat cylindrical sample excited by a shaker. These material parameters are estimated on the basis of an Inverse Method that minimizes the difference between measured data and a prediction from a finite-element model (FEM), in which the sought-after material data are the adjustable parameters. The results are presented for measurements within the 10-400-Hz frequency range under atmospheric pressure and temperature conditions. At first, the measured data are compared with FEM predictions using constant material parameters to show the material behavior in principle. Afterward, the frequency dependence of the moduli and Poisson's ratios are determined by matching measurements with simulations within small frequency ranges. Finally, the material parameters determined are given as functions versus frequency. A sensitivity analysis shows the accuracy of the presented method. This paper is motivated by the need for a precise description of vocal fold models, commonly manufactured from silicone rubber.
Performance of feedlot steers fed diets containing laidlomycin propionate or monensin plus tylosin, and effects of laidlomycin propionate concentration on intake patterns and ruminal fermentation in beef steers during adaptation to a high-concentrate diet.

Two hundred eighty-eight beef steers (British x Continental x Brahman) were fed a 90% concentrate diet containing either no ionophore (control), laidlomycin propionate at either 6 or 12 mg/kg of dietary DM, or monensin plus tylosin (31 and 12 mg/kg of DM, respectively). Neither of the two levels of laidlomycin propionate nor monensin plus tylosin affected (P greater than .10) ADG or feed:gain ratio. Monensin plus tylosin reduced (P less than .01) daily DMI for the 161-d trial period compared with the other three treatments. Laidlomycin propionate at 6 mg/kg increased (P less than .05) DMI relative to the control, laidlomycin propionate at 12 mg/kg, and monensin plus tylosin diets during the 2nd wk of the trial and from d 57 to 84. Treatments did not affect carcass measurements. In a second experiment, 12 ruminally cannulated steers were fed diets containing no ionophore or laidlomycin propionate at either 6 or 12 mg/kg of DM. Samples were obtained for two consecutive days while the dietary concentrate level was 75%, after which the diet was switched abruptly to 90% concentrate, and samples were collected on several days during a 21-d period. The rate at which steers consumed their daily allotment of feed was not altered markedly by laidlomycin propionate. Likewise, laidlomycin propionate did not affect total ruminal VFA concentrations or proportions. Ruminal concentrations of D-lactate were reduced (P less than .10) by 6 but not by 12 mg/kg of laidlomycin propionate. (ABSTRACT TRUNCATED AT 250 WORDS)
Stabilisation of medial shoulder instability by imbrication of the subscapularis muscle tendon of insertion.

OBJECTIVES To evaluate the efficacy of subscapularis muscle tendon of insertion imbrication as a treatment for medial shoulder instability. METHODS Medial shoulder instability was diagnosed in five dogs. Initial management with medical or arthroscopic treatment failed to fully resolve lameness in four of the cases. Each case was treated by subscapularis muscle tendon of insertion imbrication. An anatomical model of medial shoulder instability was used to assess the effect of subscapularis muscle tendon of insertion imbrication on the angle of abduction of the shoulder. RESULTS In clinical study, subscapularis muscle tendon of insertion imbrication was performed in five cases. Lameness resolved fully in three cases and partially in two cases. In cadaver study, transection of either the subscapularis muscle tendon of insertion or the subscapularis muscle tendon of insertion and medial glenohumeral ligament significantly increased the angle of abduction. Imbrication of the subscapularis muscle tendon of insertion significantly reduced the angle of abduction. No significant differences were noted between the angle of abduction of normal shoulder and the shoulder with medial shoulder instability treated by subscapularis muscle tendon of insertion imbrication. CLINICAL SIGNIFICANCE Subscapularis muscle tendon of insertion imbrication is a moderately effective procedure for the management of medial shoulder instability unresponsive to medical and/or arthroscopic management. The angle of abduction of the shoulder was returned to normal in model of medial shoulder instability, following subscapularis muscle tendon of insertion. Subscapularis muscle tendon of insertion imbrication provides a relatively simple method of treating medial shoulder instability in dogs.
Recovery of As-Yet-Uncultured Soil Acidobacteria on Dilute Solid Media

ABSTRACT A growing number of Acidobacteria strains have been isolated from environments worldwide, with most isolates derived from acidic samples and affiliated with subdivision 1. We recovered 18 Acidobacteria strains from an alkaline soil, among which 11 belonged to the previously uncultured subdivision 6. Various medium formulations were tested for their effects on Acidobacteria growth.
Type and route of estrogen administration

Hormone replacement therapy (HRT) can be administered orally and non-orally. Providing equivalent doses are given, all forms of HRT can equally relieve menopausal symptoms and prevent bone loss and osteoporosis. Different routes of administration will have differing metabolic effects, with oral HRT producing a hepatic first-pass effect not seen with non-oral HRT. The first-pass effect can produce benefits including larger reductions in low density lipoprotein cholesterol, lipoprotein(a) and insulin resistance, and larger increases in high density lipoprotein cholesterol. Unwanted effects are seen in increases in triglycerides and in coagulation activation. Cardiovascular effects of oral and transdermal HRT appear to be fairly similar, with improvements in vascular endothelial function, angiotensin-converting-enzyme activity, and in most markers of inflammation. There is a paucity of studies on the effects of transdermal HRT on cardiovascular outcomes, but the few data available suggest similar effects to oral HRT, and dose rather than route of administration is probably more important in this respect. Oral HRT may be preferred in women with evidence of insulin resistance, such as in metabolic syndrome or maturity-onset diabetes mellitus. Transdermal HRT may be preferred in women with coagulation disturbances. But, for the majority of women, personal preference should determine their choice of HRT route.
Sortilin Expression Is Essential for Pro-Nerve Growth Factor-Induced Apoptosis of Rat Vascular Smooth Muscle Cells

Background Sortilin, a member of the Vps10p-domain receptor family, has been demonstrated a key regulator in mediating cellular response to pro-neurotrophins. In the present study, we investigated the role of sortilin in the apoptotic pathway of vascular smooth muscle cells. Methods and Principal Findings Immunohistochemistry revealed that sortilin was barely detectable in human and rat normal young vessels, while its expression was increased in human fibroatheromatous plaques. Sortilin immunodetection was also marked in the neointima of the rat aorta fifteen days after ballooning. In vitro, rat aortic intimal cells expressed higher sortilin levels than normal media SMCs; sortilin was distributed in the cytoplasm and in correspondence of the cell membrane. After 48 h, pro-nerve growth factor (proNGF) induced the strong dose-dependent increase of intimal cell apoptosis and the accumulation of sortilin protein. ProNGF was a more potent apoptotic inducer than equimolar or even higher concentration of NGF, whereas brain derived neutrotrophic factor was ineffective. Targeted interfering RNA-mediated sortilin reduction counteracted proNGF-induced apoptosis without affecting p75NTR expression. ProNGF-induced apoptosis was associated to NF-κB down-regulation and bax increase. Inhibition of NF-κB activity increased intimal cell apoptosis that did not further increase with the addition of proNGF. Conclusions Our results indicate that sortilin expression characterizes human atheromatous lesions and rat aortic post-injury neointima, and suggest that sortilin represents an important regulator of proNGF-induced SMC apoptosis and arterial remodeling.
A Mechanism for Tamoxifen-mediated Inhibition of Acidification*

Tamoxifen has been reported to inhibit acidification of cytoplasmic organelles in mammalian cells. Here, the mechanism of this inhibition is investigated using in vitroassays on isolated organelles and liposomes. Tamoxifen inhibited ATP-dependent acidification in organelles from a variety of sources, including isolated microsomes from mammalian cells, vacuoles from Saccharomyces cerevisiae, and inverted membrane vesicles from Escherichia coli. Tamoxifen increased the ATPase activity of the vacuolar proton ATPase but decreased the membrane potential (V m ) generated by this proton pump, suggesting that tamoxifen may act by increasing proton permeability. In liposomes, tamoxifen increased the rate of pH dissipation. Studies comparing the effect of tamoxifen on pH gradients using different salt conditions and with other known ionophores suggest that tamoxifen affects transmembrane pH through two independent mechanisms. First, as a lipophilic weak base, it partitions into acidic vesicles, resulting in rapid neutralization. Second, it mediates coupled, electroneutral transport of proton or hydroxide with chloride. An understanding of the biochemical mechanism(s) for the effects of tamoxifen that are independent of the estrogen receptor could contribute to predicting side effects of tamoxifen and in designing screens to select for estrogen-receptor antagonists without these side effects.
Hybridization of cultivated Vitis vinifera with wild V. californica and V. girdiana in California

Abstract Hybridization of introduced domesticates and closely related natives is well documented in annual crops. The widespread introduction of the domesticated grapevine, Vitis vinifera, into California where it overlaps with two native congenerics, with which it is interfertile, provides opportunity to investigate hybridization between woody perennials. Although geographically widespread, the introduction over the past two centuries has been limited to a few elite clonal cultivars, providing a unique opportunity to study the effects of hybridization on the native species. The amount of hybridization with V. vinifera and the genetic diversity of wild‐growing Vitis californica and Vitis girdiana were examined using nineteen microsatellite markers. STRUCTURE analysis was used to define hybrid and introgressed individuals and to analyze genetic structure of the native species. FAMOZ software was used to identify which V. vinifera cultivars served as parents of F 1 hybrids. The three species were clearly distinguished by STRUCTURE analysis. Thirty percent of 119 V. californica vines were hybrids. The domesticated parent was identified for 16 F 1 hybrid vines; the original California cultivar, ‘Mission’, was the parent of eight. Backcrosses were also found, showing introgression into subsequent generations. Similar results were obtained for a small sample of V. girdiana. Removing hybrids greatly reduced the genetic variation of the presumed pure species, among which there was essentially no genetic structure. Limited genetic variability indicates the California natives may be threatened by genetic erosion. The discovery of F 1 hybrids of ‘Mission’, a cultivar not grown in the areas for ~100 years, suggests long generation times for wild vines that, often, grow into expansive liana and propagate by layering, all factors that limit recruitment in populations already disjunct by habitat lose. Hermaphroditic flowers and fruit that is more attractive to birds may favor the production of backcross seed and establishment of introgressed individuals.
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.

BACKGROUND The neurotransmitters dopamine and glutamate have been implicated in the prefrontal dysfunction associated with schizophrenic illness. Studies suggest that the D1 subclass of dopamine receptor and the N-methyl-D-aspartate subclass of glutamate receptor are involved in this prefrontal dysfunction. These 2 receptors regulate, in opposing directions, the amount of phosphorylated activated DARPP-32, a potent inhibitor of protein phosphatase 1 that modulates the activity of several classes of receptors and ion channels. Thus, DARPP-32 occupies a key regulatory position, and may play an important role in the pathophysiological changes in dopamine and glutamate function reported in patients with schizophrenia. METHODS The amounts of DARPP-32, synapsin I, and the alpha subunit of calcium/calmodulin-dependent protein kinase II were measured by immunoblotting in postmortem samples from 14 schizophrenic subjects and their age-, gender-, and autolysis time-matched control subjects. Possible confounding influences of neuroleptic treatment were analyzed by comparing subjects with Alzheimer disease who were and were not treated with neuroleptic agents. RESULTS DARPP-32 was significantly reduced in the dorsolateral prefrontal cortex in more schizophrenic subjects relative to matched controls. The ratios of 2 other synaptic phosphoproteins, synapsin I and the alpha subunit of calcium/calmodulin-dependent protein kinase II, did not differ between schizophrenic and control subjects, nor between subjects with Alzheimer disease who were and were not treated with neuroleptic agents. CONCLUSIONS Our findings are consistent with a selective reduction in DARPP-32 levels in schizophrenic subjects. This may be involved in the prefrontal dysfunction associated with schizophrenia.
Comparison of computerized surveillance and manual chart review for adverse events

OBJECTIVE To understand how the source of information affects different adverse event (AE) surveillance methods. DESIGN Retrospective analysis of inpatient adverse drug events (ADEs) and hospital-associated infections (HAIs) detected by either a computerized surveillance system (CSS) or manual chart review (MCR). MEASUREMENT Descriptive analysis of events detected using the two methods by type of AE, type of information about the AE, and sources of the information. RESULTS CSS detected more HAIs than MCR (92% vs 34%); however, a similar number of ADEs was detected by both systems (52% vs 51%). The agreement between systems was greater for HAIs than ADEs (26% vs 3%). The CSS missed events that did not have information in coded format or that were described only in physician narratives. The MCR detected events missed by CSS using information in physician narratives. Discharge summaries were more likely to contain information about AEs than any other type of physician narrative, followed by emergency department reports for HAIs and general consult notes for ADEs. Some ADEs found by MCR were detected by CSS but not verified by a clinician. LIMITATIONS Inability to distinguish between CSS false positives and suspected AEs for cases in which the clinician did not document their assessment in the CSS. CONCLUSION The effect that information source has on different surveillance methods depends on the type of AE. Integrating information from physician narratives with CSS using natural language processing would improve the detection of ADEs more than HAIs.