Miracle-dz/UniFAR-FTUs huggingface dataset:
Selectin binding is essential for peritoneal carcinomatosis in a xenograft model of human pancreatic adenocarcinoma in pfp−−/rag2−− mice

Background and objective E- and P-selectins expressed on the luminal surface of mesodermally derived endothelial cells play a crucial role in the formation of haematogenous metastases in a number of malignancies. As peritoneal mesothelial cells are also derived form the mesoderm, it was hypothesised that selectins are also of importance in peritoneal tumour spread. Methods Immunohistochemistry was used to identify selectin expression on normal human peritoneum and isolated mesothelial cells. E- and P-selectin interactions with human pancreatic adenocarcinoma cells were investigated in dynamic flow assays and flow cytometry; the latter was also used to determine the main selectin ligands on pancreatic adenocarcinoma cell lines PaCa 5061, BxPC-3 and PaCa 5072, and selectin expression on human mesothelial cells. All cell lines were xenografted into the peritoneum of E- and P-selectin-deficient pfp/rag2 mice and selectin wild-type controls. Peritoneal carcinomatosis was quantified using MRI or a scoring system. Results E- and P-selectin were constitutively expressed on human mesothelial and endothelial cells in the peritoneum. PaCa 5061 and BxPC-3 cells interacted with E- and P-selectins in dynamic flow assays and flow cytometry, with CA19-9 (Sialyl Lewis a) being the main E-selectin ligand. For xenografted PaCa 5061 and BxPC-3 cells, peritoneal metastasis was significantly reduced in E- and P-selectin double knockout mice compared with wild-type pfp/rag2 animals. In contrast, PaCa 5072 cells were almost devoid of selectin binding sites and no intraperitoneal tumour growth was observed. Conclusion Interactions of tumour cells with peritoneal selectins play an important role in the peritoneal spread of pancreatic adenocarcinoma.
Effects of Sulpiride on True and False Memories of Thematically Related Pictures and Associated Words in Healthy Volunteers

Episodic memory, working memory, emotional memory, and attention are subject to dopaminergic modulation. However, the potential role of dopamine on the generation of false memories is unknown. This study defined the role of the dopamine D2 receptor on true and false recognition memories. Twenty-four young, healthy volunteers ingested a single dose of placebo or 400 mg oral sulpiride, a dopamine D2-receptor antagonist, just before starting the recognition memory task in a randomized, double-blind, and placebo-controlled trial. The sulpiride group presented more false recognitions during visual and verbal processing than the placebo group, although both groups had the same indices of true memory. These findings demonstrate that dopamine D2 receptors blockade in healthy volunteers can specifically increase the rate of false recognitions. The findings fit well the two-process view of causes of false memories, the activation/monitoring failures model.
Étude préliminaire des niveaux de conscience émotionnelle chez des patients déprimés et des contrôles. Discussion

Lane et al. ont elabore une echelle de niveaux de conscience emotionnelle pour mesurer la capacite a decrire l'eprouve emotionnel personnel et d'autrui en situation emotionnelle. Le systeme de cotation de cette echelle est fonde sur l'analyse du contenu verbal des reponses fournies a des mises en situation emotionnelles et se refere directement a la theorie des differents degres de differenciation et d'integration des emotions de ces auteurs. Le concept de bas niveau de conscience emotionnelle peut etre rapproche de celui d'alexithymie, tous deux signant un deficit de regulation emotionnelle. Pour tester la pertinence de la LEAS pour rendre compte des perturbations emotionnelles manifestes dans la depression, une etude comparative des niveaux de conscience emotionnelle et d'alexithymie a ete realisee chez des patients deprimes sans comorbidites (n = 15) apparies a des sujets sains (n = 15) ayant complete les versions francaises de la LEAS et de la TAS 20. D'une maniere generale, les resultats suggerent que les patients deprimes ont un deficit du fonctionnement affectif. L'utilisation des questionnaires a permis de quantifier ce deficit et de situer les capacites de conscience emotionnelle des patients deprimes par rapport au modele cognitivo-developpemental des capacites emotionnelles de Lane et Schwartz. De plus, il semble que ce soit particulierement la capacite a attribuer un eprouve emotionnel a autrui qui est alteree chez les patients deprimes.
Peripheral Blood Abnormalities in Alzheimer Disease: Evidence for Early Endothelial Dysfunction

Clinical and epidemiologic studies demonstrate that vascular risk factors may be involved in Alzheimer disease (AD). To evaluate whether vascular abnormalities are an early feature of AD, several parameters of coagulation and fibrinolysis were assessed. Thirty patients with mild AD and 30 age-matched control subjects entered the study. All subjects performed a standardized clinical and laboratory protocol. Persons with vascular risk factors and systemic diseases were excluded. AD patients present significant increased levels of thrombomodulin (p < 0.0001) and sE-selectin (p < 0.03). In contrast, no difference was found between the two diagnostic groups in the levels of &bgr;-thromboglobulin, prothrombin fragment 1+2, fibrinogen, and von Willebrand factor. No other association but diagnosis was found with thrombomodulin and sE-selectin. These findings suggest that endothelial dysfunction is an early event in AD patients.
Towards a new approach for generating user profile from folksonomies

The exploitation of social networks and collaborative systems is a phenomenon that is gradually integrated with the practice of information retrieval on the Internet. These systems of Web 2.0, allowing users to collaborate via the free content indexing using keywords or tags; creating structures represented as tripartite hypergraphs of users, tags and resources, called folksonomies. By examining different personalization techniques based on folksonomies, we focused on the community aspect of collaborative systems. We propose to build, through different techniques of social network analysis, user profiles more representative of their various interets. A new approach for generating user profile from foklsonomies is presented.
Can creative podcasting promote deep learning? The use of podcasting for learning content in an undergraduate science unit

This paper examines the effect of a podcasting task on the examination performance of several hundred first-year chemistry undergraduate students. Educational researchers have established that a deep approach to learning that promotes active understanding of meaning can lead to better student outcomes, higher grades and superior retention of knowledge over time. We attempted to promote such an approach by setting a task that involved student collaboration, contextualisation of content, and communication through new media, specifically creative podcasting. Examination results were used as a source of empirical evidence of changes in understanding and retention that occurred for students who completed this task. In comparing results across 2 years on similar questions related to the podcasting topics, we found a statistically significant improvement after introduction of the podcasting task on the questions related to one of the topics on which students had actively created their own podcasts ('acids & bases'), but not on the other ('oxidisation and reduction'). Improved learning outcomes in the form of better understanding and retention over time in at least one JOUR suggest that under some circumstances creative podcasting may indeed help to promote a deep learning approach. [ABSTRACT FROM AUTHOR]
Active disk meets flash: a case for intelligent SSDs

Intelligent solid-state drives (iSSDs) allow execution of limited application functions (e.g., data filtering or aggregation)on their internal hardware resources, exploiting SSD characteristics and trends to provide large and growing performance and energy efficiency benefits. Most notably, internal flash media bandwidth can be significantly (2-4x or more) higher than the external bandwidth with which the SSD is connected to a host system, and the higher internal bandwidth can be exploited within an iSSD. Also, SSD bandwidth is projected to increase rapidly over time, creating a substantial energy cost for streaming of data to an external CPU for processing, which can be avoided via iSSD processing. This paper makes a case for iSSDs by detailing these trends, quantifying the potential benefifits across a range of application activities, describing how SSD architectures could be extended cost-effectively, and demonstrating the concept with measurements of a prototype iSSD running simple data scan functions. Our analyses indicate that, with less than a 2% increase in hardware cost over a traditional SSD, an iSSD can provide 2-4x performance increases and 5-27x energy efficiency gains for a range of data-intensive computations.
Benzene and the dose-related incidence of hematologic neoplasms in China. Chinese Academy of Preventive Medicine--National Cancer Institute Benzene Study Group.

BACKGROUND Benzene is a widely distributed environmental contaminant known to cause leukemia, particularly acute nonlymphocytic leukemia, and perhaps other hematologic neoplasms and disorders. Few epidemiologic studies, however, have been able to address relationships between the extent of benzene exposure and the level of risk. PURPOSE A large cohort study was carried out in China to evaluate the risks of developing specific hematologic neoplasms and selected related disorders in relationship to quantitative estimates of occupational benzene exposure. METHODS A cohort of 74828 benzene-exposed and 35805 unexposed workers employed from 1972 through 1987 in 12 cities in China was identified and followed to determine the incidence of hematologic neoplasms and related disorders. Estimates of benzene exposure were derived from work histories and available historic benzene measurements. Existing pathologic material and supporting medical records were reviewed to establish diagnoses of disease. Relative risks (RRs) (i.e., ratios of incidence rates for specific hematologic neoplasms and related disorders in the benzene-exposed group to incidence rates in the unexposed group) were determined by use of Poisson regression analysis, with stratification by age and sex. RESULTS For workers historically exposed to benzene at average levels of less than 10 parts per million (ppm), the RR for all hematologic neoplasm combined was 2.2 (95% confidence interval [CI] = 1.1-4.2), and, for the combination of acute nonlymphocytic leukemia and related myelodysplastic syndromes, the RR was 3.2 (95% CI = 1.0-10.1). For individuals who were occupationally exposed to benzene at constant levels of 25 ppm or more, the RR for the combination of acute nonlymphocytic leukemia and related myelodysplastic syndromes was 7.1 (95% CI = 2.1-23.7). Workers with 10 or more years of benzene exposure had an RR of developing non-Hodgkin's lymphoma of 4.2 (95% CI = 1.1-15.9), and the development of this neoplasm was linked most strongly to exposure that had occurred at least 10 years before diagnosis (i.e., distant exposure) (P for trend = .005, two-sided). In contrast, the risk for the combination of acute nonlymphocytic leukemia and related myelodysplastic syndromes was significantly increased among those with more recent benzene exposure (P for trend = .003, two-sided), but it was not linked to distant exposure (P for trend = .51, two-sided). CONCLUSIONS The results of this study suggest that benzene exposure is associated with a spectrum of hematologic neoplasms and related disorders in humans. Risks for these conditions are elevated at average benzene-exposure levels of less than 10 ppm and show a tendency, although not a strong one, to rise with increasing levels of exposure. The temporal pattern of benzene exposure appears to be important in determining the risk of developing specific diseases.
Cocaine Addiction as a Homeostatic Reinforcement Learning Disorder

Drug addiction implicates both reward learning and homeostatic regulation mechanisms of the brain. This has stimulated 2 partially successful theoretical perspectives on addiction. Many important aspects of addiction, however, remain to be explained within a single, unified framework that integrates the 2 mechanisms. Building upon a recently developed homeostatic reinforcement learning theory, the authors focus on a key transition stage of addiction that is well modeled in animals, escalation of drug use, and propose a computational theory of cocaine addiction where cocaine reinforces behavior due to its rapid homeostatic corrective effect, whereas its chronic use induces slow and long-lasting changes in homeostatic setpoint. Simulations show that our new theory accounts for key behavioral and neurobiological features of addiction, most notably, escalation of cocaine use, drug-primed craving and relapse, individual differences underlying dose-response curves, and dopamine D2-receptor downregulation in addicts. The theory also generates unique predictions about cocaine self-administration behavior in rats that are confirmed by new experimental results. Viewing addiction as a homeostatic reinforcement learning disorder coherently explains many behavioral and neurobiological aspects of the transition to cocaine addiction, and suggests a new perspective toward understanding addiction.
Decreased semantic competitive inhibition in Parkinson's disease: Evidence from an investigation of word search performance

Aberrant semantic competitive inhibition has been reported in Parkinson's disease (PD). Whether PD-related alterations cause an increase or a decrease in lateral inhibition, however, remains unclear. Accordingly, the present study aimed to examine semantic inhibition during lexical-semantic processing in non-demented people with PD. Twenty-two people with PD and 18 matched controls completed a computerized word search task in which both the relationship between the background items and the target (related or unrelated) and the search type (open e.g., any dog or closed e.g., collie) were manipulated. It was hypothesized that decreased semantic inhibition would be evidenced by abnormally short response times for open searches among words related to the target, while increased inhibition would lead to abnormally long response times. Analysis of the results revealed that control participants performed open searches faster for unrelated vs related word lists. In contrast, the PD group recorded similar response times regardless of background items. Hence, the present findings are consistent with the notion of decreased semantic competitive inhibition in PD and suggest that an impaired ability to inhibit unwanted information during lexical retrieval may underlie observed deficits on semantic tasks such as verbal fluency.
Between‐year variation of MHC allele frequencies in great reed warblers: selection or drift?

The major histocompatibility complex (MHC) genes are extremely polymorphic and this variation is assumed to be maintained by balancing selection. Cyclic interactions between pathogens and their hosts could generate such selection, and specific MHC alleles or heterozygosity at certain MHC loci have been shown to confer resistance against particular pathogens. Here we compare the temporal variation in allele frequencies of 23 MHC class I alleles with that of 23 neutral microsatellite markers in adult great reed warblers (a passerine bird) in nine successive cohorts. Overall, the MHC alleles showed a significantly higher variation in allele frequencies between cohorts than the microsatellite alleles, using a multi‐variate genetic analysis (amova). The frequency of two specific MHC alleles, A3e (P = 0.046) and B4b (P = 0.0018), varied more between cohorts than expected from random, whereas none of the microsatellite alleles showed fluctuations exceeding the expectation from stochastic variation. These results imply that the variation in MHC allele frequencies between cohorts is not a result of demographic events, but rather an effect of selection favouring different MHC alleles in different years.
Modeling the Control of Attention in Visual Workspaces

Objective: The present study developed and validated a stochastic model of overt attention within a visual workspace. Background: Technical specifications and recommended practices for the design of visual warning systems emphasize the role of alert salience. Task demands and display context can modulate alert noticeability, however, meaning that salience alone does not guarantee attention capture. Method: A stochastic model integrated elements from existing models of visual attention to predict attentional behavior in dynamic environments. Validation studies tested the predictions of the new model against scanning data from a high-fidelity simulator study and behavioral data from an alert detection experiment. Results: The model accurately predicted the steady-state distribution of attention within a simulated cockpit as well as the effects of color similarity, eccentricity, and dynamic visual noise on miss rates and response times in the alert detection task. Conclusion: The model successfully predicts attentional behavior in complex visual workspaces with the use of parameter values selected by either the modeler or a subject matter expert. Application: The model provides a tool to test the effectiveness of visual alerts in various display configurations and with varying task demands.
Using concept mapping to scaffold learning for students who experience learning difficulties in science classes

In order to develop scientific literacy students need the cognitive tools that enable them to read and evaluate science texts. One cognitive tool that has been widely used in science education to aid the development of conceptual understanding is concept mapping. However, it has been found some students experience difficulty with concept map construction. This study reports on the development and evaluation of an instructional sequence that was used to scaffold the concept-mapping process when middle school students who were experiencing difficulty with science learning used concept mapping to summarise a chapter of a science text. In this study individual differences in working memory functioning are suggested as one reason that students experience difficulty with concept map construction. The study was conducted using a design-based research methodology in the school’s learning support centre. The analysis of student work samples collected during the two-year study identified some of the difficulties and benefits associated with the use of scaffolded concept mapping with these students. The observations made during this study highlight the difficulty that some students experience with the use of concept mapping as a means of developing an understanding of science concepts and the amount of instructional support that is required for such understanding to develop. Specifically, the findings of the study support the use of multi-component, multi-modal instructional techniques to facilitate the development of conceptual understanding with students who experience difficulty with science learning. In addition, the important roles of interactive dialogue and metacognition in the development of conceptual understanding are identified.
NBER WORKING PAPER SERIES INSTITUTIONAL INVESTORS AND STOCK MARKET VOLATILITY

We present a theory of excess stock market volatility, in which market movements are due to trades by very large institutional investors in relatively illiquid markets. Such trades generate significant spikes in returns and volume, even in the absence of important news about fundamentals. We derive the optimal trading behavior of these investors, which allows us to provide a unified explanation for apparently disconnected empirical regularities in returns, trading volume and investor size.
Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: two phase 3 multicenter, randomized, double-blind, placebo-controlled studies.

BACKGROUND Imiquimod 3.75% and 2.5% creams were studied for the treatment of actinic keratosis (AK) of the full face or balding scalp, to determine comparable efficacy and tolerability to imiquimod 5% cream. METHODS In two identical multicenter, randomized, double-blind, placebo controlled studies. Adult subjects with 5 to 20 visible lesions, or palpable AKs in an area that exceeded 25 cm² on either the face or balding scalp were randomized to imiquimod 3.75%, 2.5% or vehicle cream (1:1:1) applied once daily for two 2-week treatment cycles, with a 2-week, no-treatment interval between cycles. Efficacy was assessed 8 weeks posttreatment (End of Study Visit [EOS]). Primary efficacy was rate of complete clearance of AK lesions. Secondary efficacy endpoints were rate of partial clearance at EOS (≥ 75% reduction in number of AK lesions compared to baseline) and median percent decrease from baseline lesion count. Safety assessments included visual assessment of local skin reactions (LSRs), number and duration of study treatment rest periods required due to intolerant LSRs, adverse events (AEs) and clinical laboratory tests. RESULTS Overall 479 patients were randomized to imiquimod 3.75%, 2.5%, or vehicle. Complete clearance rates were 35.6%, 30.6%, and 6.3% respectively (both P<.001 versus vehicle). The difference in complete clearance rates (imiquimod minus vehicle) was 29.3% and 24.3%, respectively. Partial clearance rates were 59.4%, 48.1%, and 22.6% respectively (both P<.001 versus vehicle). Median % reductions in AK lesions were 81.8%, 71.8%, and 25.0% respectively (-<.001 versus vehicle). All primary and secondary efficacy endpoints were greater in Study 1. Photodamage in the treatment area was 'much improved' with imiquimod 3.75%. Both active creams were well tolerated with few treatment-related discontinuations. CONCLUSIONS In two well-controlled Phase 3 studies, both imiquimod 3.75% and 2.5% creams were more effective than vehicle and well tolerated when administered daily as a 2-week on/off/on regimen to treat AK. Reduction in AK lesions was comparable to that reported with imiquimod 5% with fewer local AEs.
Wave propagation in single- and double-walled carbon nanotubes filled with fluids

Wave propagation approach of single- and double-walled carbon nanotubes conveying fluid is presented through the use of the continuum mechanics. A simplified Flugge shell equations are proposed as the governing equations of motion for carbon nanotubes studied here. For the double-walled nanotubes, the deflection of nested tubes is considered to be coupled through the van der Waals interaction between two adjacent nanotubes. Effects of filled fluid property and nanotube diameter on the wave propagation are investigated and analyzed based on the proposed elastic continuum model. The theoretical investigation may give a useful reference for potential design and application of nanoelectronics and nanodevices.