Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women

A combination of soy isoflavones and Liu Wei Di Huang Wan (LWDHW) is potentially effective for postmenopausal women with intolerable vasomotor episodes who are not suitable candidates for hormonal therapy. The objective of this open-label, three-phase, crossover study was to determine the influence of both single and multiple oral doses of LWDHW on isoflavone pharmacokinetics in healthy postmenopausal women. Eleven subjects were assigned to receive the following regimens in a fixed sequence with washout periods of at least one week: Phase A, a single oral dose of soy milk; Phase B, a single oral dose of soy milk coadministered with LWDHW; and Phase C, multiple oral doses of LWDHW for 14 days followed by a single oral dose of soy milk. Blood samples were collected and mixed with β-glucuronidase/sulfatase to hydrolyze isoflavone conjugates to their respective aglycones (i.e., daidzein and genistein) and were determined using high performance liquid chromatography. The pharmacokinetic parameters analyzed were maximal plasma concentration (C max), time to reach peak concentration (T max), area under the plasma concentration-time curve (AUC), and half-life (t 1/2). The results found no statistically significant differences in pharmacokinetic parameters of daidzein and genistein among the three regimens.
Quorum sensing allows T cells to discriminate between self and nonself

T cells orchestrate pathogen-specific adaptive immune responses by identifying peptides derived from pathogenic proteins that are displayed on the surface of infected cells. Host cells also display peptide fragments from the host’s own proteins. Incorrectly identifying peptides derived from the body’s own proteome as pathogenic can result in autoimmune disease. To minimize autoreactivity, immature T cells that respond to self-peptides are deleted in the thymus by a process called negative selection. However, negative selection is imperfect, and autoreactive T cells exist in healthy individuals. To understand how autoimmunity is yet avoided, without loss of responsiveness to pathogens, we have developed a model of T-cell training and response. Our model shows that T cells reliably respond to infection and avoid autoimmunity because collective decisions made by the T-cell population, rather than the responses of individual T cells, determine biological outcomes. The theory is qualitatively consistent with experimental data and yields a criterion for thymic selection to be adequate for suppressing autoimmunity.
Effectiveness of Cyber Bullying Sensitization Program (CBSP) to Reduce Cyber Bullying Behavior Among Middle School Children

Cyber bullying is the unwise use of technology to harm and humiliate an individual or group over the Internet. The purpose of this article is to test the effectiveness of the cyber bullying sensitisation program (CBSP) to reduce the level of cyber bullying behaviour among middle school students. The sample was restricted to adolescents as they are the ones who are most exposed and vulnerable in the cyber space. A quasi-experimental pre-post design with intervention was adopted for the study. The participants of the study were comprised of 186 middle school students from two private schools in India. The experimental group had 94 participants while control groups had 92 participants. Statistical analysis indicated that there was a significant difference between pre- and post-test scores in the experimental group. No significant difference was found between the experiment and control group before the program, suggesting that the program was effective in helping students in reducing cyber bullying behaviour. The implications for prevention and intervention programs were discussed.
Improving Clinical Diagnosis Inference through Integration of Structured and Unstructured Knowledge

This paper presents a novel approach to the task of automatically inferring the most probable diagnosis from a given clinical narrative. Structured Knowledge Bases (KBs) can be useful for such complex tasks but not sufficient. Hence, we leverage a vast amount of unstructured free text to integrate with structured KBs. The key innovative ideas include building a concept graph from both structured and unstructured knowledge sources and ranking the diagnosis concepts using the enhanced word embedding vectors learned from integrated sources. Experiments on the TREC CDS and HumanDx datasets showed that our methods improved the results of clinical diagnosis inference.
Spatio–Temporal Transform Based Video Hashing

Identification and verification of a video clip via its fingerprint find applications in video browsing, database search and security. For this purpose, the video sequence must be collapsed into a short fingerprint using a robust hash function based on signal processing operations. We propose two robust hash algorithms for video based both on the discrete cosine transform (DCT), one on the classical basis set and the other on a novel randomized basis set (RBT). The robustness and randomness properties of the proposed hash functions are investigated in detail. It is found that these hash functions are resistant to signal processing and transmission impairments, and therefore can be instrumental in building database search, broadcast monitoring and watermarking applications for video. The DCT hash is more robust, but lacks security aspect, as it is easy to find different video clips with the same hash value. The RBT based hash, being secret key based, does not allow this and is more secure at the cost of a slight loss in the receiver operating curves
Stereological study of the effect of ginger's alcoholic extract on the testis in busulfan-induced infertility in rats

Background: In traditional medicine zingiber officinale used to regulate female menstural cycle and treat male infertility. Recent studies have suggested the possible role of ginger extract in improving the testicular damage of busulfan. Objective: The aim of this study was to evaluate the effects of zingiber officinale on the sperm parameters, testosterone level and the volume of the testes and seminiferous tubules by stereological methods. Materials and Methods: Fifty rats were divided into four groups. All the rats were given a single intraperitoneally injection of 5mg/kg busulfan solution. The first group was kept as busulfan control, while the other groups were orally administrated ginger extract in graded doses of 50, 100 and 150mg/kg b.wt, for 48 consecutive days. At the end, all animals were anesthetized and their testes and vas deference were removed, fixed, embedded, and stained. The volume of testes and seminiferous tubules were estimated by cavalieri methods. Results: The result showed, that zingiber officinale increased the volumes of seminiferous tubule in 100mg/kg treated group compared to control group. Sperm count (706×105 and 682×105) and the level of testosterone (50.90 ng/mL and 54.10 ng/mL) enhanced in 100 mg/kg and 150 mg/kg treated groups compared to control group (p=0.00). Conclusion: It seems that zingiber officinale stimulate male reproductive system in induce busulfan infertility.
Hierarchical star formation in M33: fundamental properties of the star-forming regions

Star formation within galaxies appears on multiple scales, from spiral structure, to OB associations, to individual star clusters, and often substructure within these clusters. This multitude of scales calls for objective methods to find and classify star-forming regions, regardless of spatial size. To this end, we present an analysis of star-forming groups in the local group spiral galaxy M33, based on a new implementation of the minimum spanning tree method. Unlike previous studies which limited themselves to a single spatial scale, we study star-forming structures from the effective resolution limit (∼~20 pc) to kpc scales. Once the groups are identified, we study their properties, for example, size and luminosity distributions, and compare them with studies of young star clusters and giant molecular clouds (GMCs). We find evidence for a continuum of star-forming group sizes, which extends into the star cluster spatial scale regime. We do not find a characteristic scale for OB associations, unlike that found in previous studies, and we suggest that the appearance of such a scale was caused by spatial resolution and selection effects. The luminosity function of the groups is found to be well represented by a power law with an index, −2, the same as has been found for the luminosity and mass functions (MFs) of young star clusters, as well as the MF of GMCs. Additionally, the groups follow a similar mass–radius relation as GMCs. The size distribution of the groups is best described by a lognormal distribution, the peak of which is controlled by the spatial scale probed and the minimum number of sources used to define a group.We show that within a hierarchical distribution, if a scale is selected to find structure, the resulting size distribution will have a lognormal distribution. We find an abrupt drop of the number of groups outside a galactic radius of ~4 kpc (although individual high-mass stars are found beyond this limit), suggesting a change in the structure of the star-forming interstellar medium, possibly reflected in the lack of GMCs beyond this radius. Finally, we find that the spatial distribution of HII regions, GMCs, and star-forming groups are all highly correlated.
Physical education-related home–school collaboration: The experiences of parents of children with disabilities

In this hermeneutic phenomenological study, we describe the physical education (PE)-related home–school collaboration as experienced by parents of children with disabilities. We further explore which conditions parents experienced as either promoting or inhibiting the collaborative relationship and how they became involved in school activities to secure quality education in PE. The data consisted of 25 semi-structured interviews with parents of children with disabilities. Inductive thematic analysis generated five themes: (1) lack of PE-related information; (2) contradictory expectations; (3) competence and continuous systematic communication; (4) involvement in school-based activity; and (5) navigating the system. PE was often absent in the formal collaboration between home and school. The conditions emphasised as inhibiting collaboration were lack of information, contradictory expectations, conflict over resources and short-sighted planning. The promoting conditions were continuous systematic communication, trust in the competencies of the school personnel, and joint problem solving and collaboration among professionals. The study illuminates the ways in which parents informally involved themselves in their children’s education and their use of various strategies to promote participation and quality in PE.
How Central and Eastern European Countries Choose Exchange Rate Regimes

In this study, we identify the main determinants of the exchange rate regime choices in Central and Eastern European countries (CEECs). For this purpose, we use an ordered logit model for the official (de jure) and the actual (de facto) exchange rate classifications. We find that trade openness and concentration, inflation differentials, international reserves stocks and financial conditions are the main determinants of the selection of exchange rate regimes in the CEECs.
Identification of synthetic and natural emotional facial expressions

Identification of emotional expressions of a Talking Head (TH) were evaluated and compared to that of natural faces. In addition, the effect of static (pictures) and dynamic (video sequences) stimuli was studied. Natural stimuli consisted of six basic emotional expressions (anger, disgust, fear, happiness, sadness and surprise). Two expression sets were selected from both Ekman-Friesen facial affect pictures [1] and Cohn-Kanade database [2]. In addition, two new natural expression sets were recorded in our laboratory. Synthetic expressions were created by our new TH [3], both with and without facial texture. Preliminary results indicate that the TH expressions, except fear, were identified as expected. Overall level of identification of TH stimuli was below those of natural ones. Of all used stimuli, happiness was identified the best and fear the worst. Natural static and dynamic expressions were identified equally well. However, the dynamic expressions of the TH were identified significantly more accurately than the static ones.
Evolution along the Great Rift Valley: phenotypic and genetic differentiation of East African white‐eyes (Aves, Zosteropidae)

Abstract The moist and cool cloud forests of East Africa represent a network of isolated habitats that are separated by dry and warm lowland savannah, offering an opportunity to investigate how strikingly different selective regimes affect species diversification. Here, we used the passerine genus Zosterops (white‐eyes) from this region as our model system. Species of the genus occur in contrasting distribution settings, with geographical mountain isolation driving diversification, and savannah interconnectivity preventing differentiation. We analyze (1) patterns of phenotypic and genetic differentiation in high‐ and lowland species (different distribution settings), (2) investigate the potential effects of natural selection and temporal and spatial isolation (evolutionary drivers), and (3) critically review the taxonomy of this species complex. We found strong phenotypic and genetic differentiation among and within the three focal species, both in the highland species complex and in the lowland taxa. Altitude was a stronger predictor of phenotypic patterns than the current taxonomic classification. We found longitudinal and latitudinal phenotypic gradients for all three species. Furthermore, wing length and body weight were significantly correlated with altitude and habitat type in the highland species Z. poliogaster. Genetic and phenotypic divergence showed contrasting inter‐ and intraspecific structures. We suggest that the evolution of phenotypic characters is mainly driven by natural selection due to differences in the two macro‐habitats, cloud forest and savannah. In contrast, patterns of neutral genetic variation appear to be rather driven by geographical isolation of the respective mountain massifs. Populations of the Z. poliogaster complex, as well as Z. senegalensis and Z. abyssinicus, are not monophyletic based on microsatellite data and have higher levels of intraspecific differentiation compared to the currently accepted species.
Ten-Year Cumulative Incidence of Diabetic Retinopathy. The Beijing Eye Study 2001/2011

Objective To assess the cumulative 10-year incidence of diabetic retinopathy (DR) and its associated factors in a population living in Greater Beijing. Methods The population-based longitudinal Beijing Eye Study, which included 4439 subjects (age in 2001: 40+years) in 2001, was repeated in 2011 with 2695 subjects participating (66.4% of the survivors). The study participants underwent a detailed ophthalmic examination. Fundus photographs were examined for the new development of DR. Results After excluding individuals with DR at baseline (n = 87) or no sufficient fundus photographs in 2011 (n = 6), the study included 2602 subjects with a mean age of 64.6±9.7 years (median: 64.0 years; range: 50 to 93 years). In the 10-year period, 109 subjects (39 men) developed new DR with an incidence of 4.2% (95% confidence interval (CI): 3.45,5.03). In multiple logistic regression analysis, incident DR was significantly associated with higher HbA1c value (P<0.001; Odds Ratio (OR): 1.73; 95% Confidence Interval (CI): 1.35,2.21), longer duration of diabetes mellitus (P<0.001; OR: 1.16; 95% CI: 1.10,1.22), higher serum concentration of creatinine (P = 0.02; OR: 1.01; 95% CI: 1.002,1.022), lower educational level (P = 0.049; OR: 0.74; 95% CI: 0.55,0.99), higher estimated cerebrospinal fluid pressure (P = 0.038; OR: 1.10; 95% CI: 1.01,1.22), and shorter axial length (P<0.001; OR: 0.48; 95% CI: 0.33,0.71). Conclusions The cumulative 10-year incidence (mean: 4.2%) of DR in a North Chinese population was significantly associated with a higher HbA1c value, longer known duration of diabetes mellitus, higher estimated CSFP and shorter axial length (P<0.001). Shorter axial length (or hyperopia) and, potentially, higher CSFP may be additional risk factors to be taken into account when counseling and treating patients with diabetes mellitus.
Effect of Hypertonic Saline Infusion versus Normal Saline on Serum NGAL and Cystatin C Levels in Patients Undergoing Coronary Artery Bypass Graft

Background: Acute kidney injury (AKI) is a common and life-threatening complication following coronary artery bypass graft (CABG). Neutrophil gelatinase-associated lipocalin (NGAL) and Cystatin C have shown to be good predictive factors for AKI. Recently, there has been a growing interest in the use of hypertonic saline in cardiac operations. The purpose of this study was to evaluate the prophylactic anti-inflammatory effect of hypertonic saline (Group A) infusion versus normal saline (Group B) on serum NGAL and Cystatin C levels as the two biomarkers of AKI in CABG patients. Methods: This randomized double-blinded clinical trial recruited 40 patients undergoing CABG in Tehran Heart Center, Tehran, Iran. After applying exclusion criteria, the effects of preoperative hypertonic saline (294 meq Na) versus normal saline (154 meq Na) infusion on serum NGAL and Cystatin C levels were investigated in three intervals: before surgery and 24 and 48 hours postoperatively. The probable intraoperative or postoperative confounders, including pump time, cross-clamp time, heart rate, systolic and diastolic blood pressures, central venous pressure, arterial pH, partial pressure of arterial oxygen, fraction of inspired oxygen, blood sugar, Na, K, Mg, hemoglobins, white blood cells, hematocrits, and platelets, were recorded and compared between the two groups of study. Results: The study population comprised 40 patients, including 25 (62.5%) males, at a, mean age ± SD of 61.75 ± 8.13 years. There were no statistically significant differences between the patients’ basic, intraoperative, and postoperative characteristics, including intraoperative and postoperative hemodynamic variables and supports such as inotropic use. Intra-aortic balloon pump use and mortality were not seen in our cases. Three patients in the normal saline group and one patient in the hypertonic saline group had serum NGAL levels greater than 400 ng/ml. Moreover, 10 patients in Group A and 17 patients in group B showed a rise in serum Cystatin C levels above 1.16 mg/dl. Patients with AKI had significantly elevated NGAL and Cystatin C levels (p value < 0.001), but there were no significant differences in the decrease in the NGAL level in the hypertonic saline group versus the normal saline group (230.91 ± 92.68 vs. 239.74 ± 116.58 ng/ml, respectively; p value = 0.792), or in the decrease in the Cystatin C level in the hypertonic saline group versus the normal saline group (1.05 ± 0.26 vs. 1.06 ± 0.31, respectively; p value = 0.874). Conclusion: Pre-treatment of CABG patients with hypertonic saline had no significant effect on serum NGAL and Cystatin C levels compared to the normal saline-receiving group. Our present data, albeit promising, have yet to fully document outcome differences.
Adjusting the Value of a Statistical Life for Age and Cohort Effects

To resolve the theoretical ambiguity in the effect of age on the value of statistical life (VSL), this article uses a novel, age-dependent fatal risk measure to estimate age-specific hedonic wage regressions. VSL exhibits an inverted-U-shaped relationship with age. In the year 2000 cross section, workers' VSL rises from $3.7 million (ages 1824) to $9.7 million (3544), and declines to $3.4 million (5562). Controlling for birth-year cohort effects in a minimum distance estimator yields a peak VSL of $7.8 million at age 46, and flattens the age-VSL relationship. The value of statistical life-year also follows an inverted-U shape with age.
Collaborative Responsibility in Teacher Preparation: Student Teachers’ Perceptions of the Role of Schools in Their Professional Development in Zambia

The aim of this study was to examine student teachers’ perceptions of whether schools play a significant role in their professional development. The study employed a mixed-method design. Open and closed-ended questionnaire items were used to collect data from 74 student teachers that went for Teaching Practice from three different teacher education institutions in 2016. Simple random sampling was mainly applied when selecting respondents. Quantitative data were analyzed using the Statistical Package for Social Sciences (SPSS) to derive frequencies, percentages as well as differences and associations of the responses from the three institutions under study. Qualitative data were summed up in themes and findings related and compared with quantitative results. Results show that while students appreciated the guidance from schools, they had a large share of dissatisfaction as well. Students faced numerous system and administrative challenges that prohibited adequate practice time in schools. It was recommended that teacher education institutions establish collaboration with schools to help students benefit from mutual understanding about Teaching Practice.
A troubled youth: relations with somatization, depression and anxiety in adulthood.

BACKGROUND Childhood experiences profoundly affect later functioning as an adult. Family practitioners are well-placed to discover the links between childhood troubles and later somatization, depression or anxiety. OBJECTIVES We aimed to study the interrelation of somatization, depressive and anxiety disorders in frequently attending patients in general practice; to investigate whether these problems are related to a childhood history of illness experiences, deprivation, life events and abuse; and to determine the independent contributions of these childhood factors to the prediction of adult somatization, depressive and anxiety disorders. METHODS One hundred and six adult general practice patients with high consultation frequency were studied. Somatization was operationalized as a more comprehensive version of DSM-III-R somatization disorder (5 complaints; SSI 5/5). For depression (ever depressive and/or dysthymic) and anxiety (panic, phobias and/or generalized anxiety) DSM-III-R criteria were used. Using a structured questionnaire we assessed illness experiences, deprivation of parental care, abuse (sexual/physical) and other life events before age 19. RESULTS The overlap between somatization, depression and anxiety was largely accounted for by 16 patients with a triple problem: somatization and depression and anxiety. Somatization was specifically related to deprivation, depression to other life events. Abuse (prevalence 16%) independently predicted psychiatric problems in general. Youth experiences before age 12 were most important. CONCLUSIONS The high prevalence of triple problems suggests a need to reconsider concepts like somatic anxiety and anxious depression. The specificity of the relation between deprivation and somatization and of the relation between other life events and depression indicates that distinct causal mechanisms (in youth) contribute to these problems.
Face Recognition Under Varying Illumination Based on Ordinal Features

Illumination variation is one of the most difficult problems for face recognition. In this paper, we represent a new ordinal feature based method for face recognition under varying illumination. We employ 2-D wavelet transform to compress face images and extract ordinal features from them. Here, the ordinal feature is extracted more easily than before and competent for face recognition, which is invariant for illumination changes. Experiments are carried out on Yale B face database, and experimental results demonstrate that our proposed method achieves satisfying recognition rate under illumination variations.