Miracle-dz/UniFAR-FTUs huggingface dataset:
Event-Triggered Fixed-Time Optimal Consensus for Multi-Agent Systems

This paper develops a framework for solving the fixed-time optimal control problem of multi-agent systems (MASs) under dynamic event-triggered mechanism (DETM). To find the optimal control law, a critic-only adaptive dynamic programming (ADP) online learning algorithm is proposed to obtain the solution of Hamilton-Jacobi-Bellman (HJB) equation within a fixed time. By the designed experience replay learning rule employing sufficiently rich recorded and current data, the critic weights are updated to approximate the value function and its gradient. The unmanned aerial vehicle (UAV) systems are adopted to verify the feasibility of the presented approach.
Self‐rated health in the unwell elderly presenting to the emergency department

Objective: Self‐rated health (SRH) has been shown to be a reliable predictor of functional decline and mortality. These studies, however, have largely focused on well community‐dwelling elderly. We assessed whether the predictive value of SRH would still be valid for the acutely unwell older person presenting to the ED.
Population frequencies for CSF1PO, TPOX, TH01, F13A01, FES/FPS and VWA in seven Amerindian populations from Colombia.

POPULATION: The Amerindian population of Colombia represents around 1.7% of the population (1,2). They belong to different linguistic families (Chibcha, Tukano, Arawak, Guahibo, Choco, Maku, Karib, and Quechua among others). The Amerindian tribes of Colombia are located in the Amazonian/Orinoquian region, the Northeast, Southwest and Pacific regions of Colombia. Few studies have been carried out for STR variability among Amerindian tribes (3-5). On the other hand, several studies have been performed for STR variability in Caucasian and Afro-Colombian populations (1,2,6-10). We have carried out a study in 7 Amerindian populations named Cubeo (n = 49), Curripaco (n = 32), Desano (n = 28), Tucano (n = 26), Embera (n = 31), Puinabe (n = 77), and Nukak (n = 29) for 6 STR loci (CSF1PO, TPOX, TH01, F13A01, FES/FPS and VWA) to determine allele frequencies and other parameters of forensic importance.
Effects of NF-kappaB1 (p50) targeted gene disruption on ionizing radiation-induced NF-kappaB activation and TNFalpha, IL-1alpha, IL-1beta and IL-6 mRNA expression in vivo.

PURPOSE To investigate the role of the NF-kappaB1 (p50) gene in ionizing radiation (IR)-induced NF-kappaB activation and TNFalpha, IL-1alpha, IL-1beta and IL-6 mRNA expression in vivo. MATERIALS AND METHODS NF-kappaB activation was analysed by the gel shift/supershift assay and the levels of TNFalpha, IL-1alpha, IL-1beta and IL-6 mRNA were measured using RNase protection assay (RPA). Various tissues from BALB/c, B6,129P-Nfkb1 (NF-kappaB1 or p50 gene knockout, p50(-/-)) and B6,129PF2 (wild-type, p50(+/+)) mice were analysed before or after exposure to a lethal dose (8.5 Gy) of total-body gamma-irradiation. RESULTS Exposure of BALB/c mice to total-body IR selectively activated NF-kappaB in the spleen, mesenteric lymph nodes (LN) and bone marrow (BM). Gel supershift assay using polyclonal antibodies against NF-kappaB p50, p65 or c-Rel protein revealed that the NF-kappaB p50 subunit is a critical component of the NF-kappaB complexes activated by IR in vivo. Discretely augmented TNFalpha, IL-1alpha, IL-1beta and IL-6 mRNA expression was found in the spleen, LN and BM after BALB/c mice received IR. However, mice lacking the p50 gene (p50(-/-)) showed a significant reduction in IR-induced activation of NF-kappaB and increases in TNFalpha, IL-1alpha, IL-1beta and IL-6 mRNA expression, as compared with that of wild-type mice (p50(+/+)). CONCLUSIONS The NF-kappaB p50 subunit is a critical component of the NF-kappaB complexes activated by IR and it plays an important role in mediating IR-induced TNFalpha, IL-1alpha, IL-1beta and IL-6 mRNA expression in vivo.
Concurrent chemoradiation therapy with oral etoposide and cisplatin for locally advanced inoperable non-small-cell lung cancer: radiation therapy oncology group protocol 91-06.

PURPOSE Patients with locally advanced inoperable non-small-cell lung cancer (NSCLC) have a poor clinical outcome. We conducted a prospective study to evaluate the merit of chemotherapy administered concurrently with hyperfractionated thoracic radiation therapy. PATIENTS AND METHODS Seventy-nine patients with inoperable NSCLC were enrolled onto a multicenter phase II trial of concurrent chemoradiation therapy. Treatment consisted of two cycles of oral etoposide 100 mg/d (50 mg/d if body-surface area [BSA] < 1.70 m2), intravenous cisplatin 50 mg/m2 on days 1 and 8, and hyperfractionated radiation therapy 5 days per week (1.2 Gy twice daily > 6 hours apart; total 69.6 Gy). RESULTS Seventy-six assessable patients with a Karnofsky performance status > or = 60 and adequate organ function who had received no prior therapy were evaluated for clinical outcome and toxic effects. After a minimum follow-up duration of 21 months, the 1- and 2-year survival rates and the median survival duration were 67%, 35%, and 18.9 months overall; they were 70%, 42%, and 21.1 months for patients with weight loss of < or = 5%. Toxicity was significant; 57% developed grade 4 hematologic toxicity, 53% grade 3 or 4 esophagitis, and 25% grade 3 or 4 lung toxicity. However, only 6.6% of patients had grade 4 or lethal nonhematologic toxicity, which included three treatment-related deaths (two of pneumonitis and one of renal failure). CONCLUSION Concurrent chemoradiation therapy with oral etoposide and cisplatin plus hyperfractionated radiation therapy is feasible. The survival outcome from this regimen compares favorably with that of other chemoradiation trials and even of multimodality trials that have included surgery.
Borrower-Lender Distance, Credit Scoring, and the Performance of Small Business Loans

We develop a theoretical model of decision-making under risk and uncertainty in which bank lenders have both imperfect information about loan applications and imperfect ability to make decisions based on that information. We test the loan-default implications of the model for a large random sample of small business loans made by U.S. banks between 1984 and 2001 under the SBA 7(a)loan program. As predicted by our model, both borrower-lender distance and credit-scoring contribute to greater loan defaults; the former finding suggests that distance interferes with information collection and monitoring, while the latter finding implies production efficiencies that encourage credit-scoring lenders to make riskier loans at the margin. However, we also find that credit-scoring dampens the harmful effects of distance, consistent with the conjecture that information generated by credit scoring models improves the ability of lenders to assess and price default risk.
Board of Directors and Shareholder Value: New Evidence *

Historically, NYSE rule 452 permitted broker discretionary voting in routine voting matters such as election of directors. Since broker discretionary voting typically follows managements’ recommendation, managements’ nominees receive more votes than would otherwise be the case. Thus, any expression of true shareholder sentiment about directors is muted. Rule 452 was amended in 2009 to eliminate discretionary broker voting in the election of directors. We employ this regulatory event as a natural experiment to examine whether there is indeed any evidence of links between shareholder value and corporate boards. We find that the elimination of discretionary broker voting is value enhancing, on average. Importantly, the effect is more pronounced for firms with weak corporate governance, which suggests that effective boards of directors, if elected, can influence firm value.
A Meta-Analysis on Antecedents and Outcomes of Detachment from Work

Detachment from work has been proposed as an important non-work experience helping employees to recover from work demands. This meta-analysis (86 publications, k = 91 independent study samples, N = 38,124 employees) examined core antecedents and outcomes of detachment in employee samples. With regard to outcomes, results indicated average positive correlations between detachment and self-reported mental (i.e., less exhaustion, higher life satisfaction, more well-being, better sleep) and physical (i.e., lower physical discomfort) health, state well-being (i.e., less fatigue, higher positive affect, more intensive state of recovery), and task performance (small to medium sized effects). However, average relationships between detachment and physiological stress indicators and work motivation were not significant while associations with contextual performance and creativity were significant, but negative. Concerning work characteristics, as expected, job demands were negatively related and job resources were positively related to detachment (small sized effects). Further, analyses revealed that person characteristics such as negative affectivity/neuroticism (small sized effect) and heavy work investment (medium sized effect) were negatively related to detachment whereas detachment and demographic variables (i.e., age and gender) were not related. Moreover, we found a medium sized average negative relationship between engagement in work-related activities during non-work time and detachment. For most of the examined relationships heterogeneity of effect sizes was moderate to high. We identified study design, samples' gender distribution, and affective valence of work-related thoughts as moderators for some of these aforementioned relationships. The results of this meta-analysis point to detachment as a non-work (recovery) experience that is influenced by work-related and personal characteristics which in turn is relevant for a range of employee outcomes.
Pengaruh Pemicuan Masalah Demam Berdarah Berbasis Masyarakat Terhadap Pengetahuan, Sikap, Dan Perilaku Pencegahan DBD Pada Kader PKK Di Kelurahan Sesetan Tahun 2013

Demam Berdarah Dengue (DBD) merupakan salah satu penyakit infeksi yang kejadiannya masih tetap tinggi. Pencegahan yang tepat harus lebih ditingkatkan untuk menurunkan angka kejadian DBD. Kelurahan Sesetan merupakan daerah yang memiliki kasus DBD tertinggi pada tahun 2011 di wilayah kerja Puskesmas I Denpasar Selatan. Metode partisipasif sangat diperlukan untuk mengajak masyarakat berperan serta dalam upaya preventif promotif, salah satunya melalui metode pemicuan masalah demam berdarah berbasis masyarakat. Penelitian ini bertujuan untuk mengetahui pengaruh pemicuan masalah demam berdarah berbasis masyarakat terhadap pengetahuan, sikap, dan perilaku pencegahan DBD pada kader PKK di Kelurahan Sesetan tahun 2013. Penelitian ini merupakan penelitian kuantitatif menggunakan rancangan Quasi Eksperimen dengan Non equivalent control group design yang menggunakan pengukuran berulang. Tujuh belas wanita mendapat intervensi. Kelompok perlakuan diberikan intervensi dengan pelatihan pemicuan DBD, sedangkan kelompok kontrol hanya diberikan leaflet. Hasil pre dan 2 kali post test dianalisis secara deskriptif dengan uji General Linear Model (GLM) Repeated Measure. Hasil penelitian ini menunjukan ada peningkatan pengetahuan, sikap dan perilaku kader PKK di Kelurahan Sesetan yang mendapatkan intervensi mengenai pencegahan DBD sebelum dan setelah diberikan pemicuan. Namun, pemicuan ini belum dapat dikatakan meningkatkan pengetahuan pada kelompok intervensi jika dibandingkan kelompok kontrol karena terjadi bias histori dan bias instrumen. Sedikit berbeda dengan hasil pengukuran sikap dan perilaku yang menunjukkan adanya peningkatan efek pada kelompok intervensi dibandingkan kelompok kontrol Disarankan kepada instansi terkait untuk mengupayakan pemicuan DBD sebagai salah satu alternatif promosi kesehatan untuk meningkatkan pengetahuan, sikap, dan perilaku dalam pencegahan demam berdarah di masyarakat.
The Impact of Digital Technology on Learning : A Summary for the Education Endowment Foundation

3 Interpreting the evidence from meta-analysis for the impact of digital technology on learning Overview The aim of this review is to present a synthesis of the evidence from meta-analysis about the impact of the use of digital technology in schools on children's attainment, or more widely the impact of digital technology on academic achievement. It is divided up into three main sections. The first sets out an overview of the wider research into the impact of technology on learning to set the context and the rationale for the value of this information. The next section reviews the evidence from meta-analysis and other quantitative syntheses of research into the impact of digital technology. A further section looks at trends in the use of digital technology and learning in the UK and internationally, to provide further context for the recommendations which follow. The purpose of this review is to identify implications for future investment in the use of digital technology for learning in schools. Digital technologies are now embedded in our society. Focus has shifted from whether or not to use them in teaching and learning, to understanding which technologies can be used for what specific educational purposes and then to investigate how best they can be used and embedded across the range of educational contexts in schools. Summary of key points Overall, the research evidence over the last forty years about the impact of digital technologies on learning consistently identifies positive benefits. The increasing variety of digital technologies and the diversity of contexts and settings in which the research has been conducted, combined with the challenges in synthesising evidence from different methodologies, makes it difficult to identify clear and specific implications for educational practice in schools. Studies linking the provision and use of technology with attainment tend to find consistent but small positive associations with educational outcomes. However a causal link cannot be inferred from this kind of research. It seems probable that more effective schools and teachers are more likely to use digital technologies more effectively than other schools. We need to know more about where and how it is used to greatest effect, then investigate to see if this information can be used to help improve learning in other contexts. We do not know if it is the use of technology that is making the difference. Research findings from experimental and quasi-experimental designs – which have been combined …
Steps and sitting in a working population

This study aimed to assess sitting time and number of steps taken each day, and the relationships between these variables, in a sample of working Australian adults. Workers (N = 185) wore a pedometer for 7 days and recorded the number of steps taken and time spent sitting each day. Average time spent sitting on weekdays was 9.4 (SD = 2.40) hr, with about half spent sitting at work. Despite this, the average steps taken each day (M = 8,873, SD = 2,757) was higher on weekdays than on weekend days. There was a clear inverse relationship between sitting time at work and number of steps taken on weekdays, r = -. 34, p < . 001); those in the highest tertile for sitting time reported about 3,000 fewer daily steps. Workers in managerial and professional occupations reported more time sitting at work (M = 6.2 hr per day) and lower weekday step counts (M = 7,883, N = 43) than technical (M = 3.3 hr sitting at work and 10,731 weekday steps, N = 33) and blue collar workers (M = 1.6 hours sitting and 11,784 steps, N = 11). The findings suggest those whose daily work involves long hours of sitting should be the focus of efforts to promote physical activity both within and outside the workplace.
Radar-Based Human Activity Acquisition, Classification and Recognition Towards Elderly Fall Prediction

Falls represent the main risk of injury for elderly people. One-third of adults aged over 65 and half of people over 80 will have at least one fall a year. People at risk should visit a clinical service to detect gait difficulties. Solutions for detecting daily activities are being studied more and more, aiming to develop a complementary method to early detect this type of health risk as effectively as possible. Non-intrusiveness in the person's life for this type of problem is an important criterion, which is why current research is focusing on solutions involving non-conventional imagery such as radar systems. This paper presents an embedded system for classifying daily activities based on the processing of micro-Doppler images. The implementation of the pre-processing chain with a filter enables the acquisition of detailed spectrograms, which proves to be effective in detecting walking. Additionally, by porting it onto the Jetson Orin, it could be possible to accelerate the inference phase of the classification model. We used the ResNet-18 classification method to classify six human activities: Walking, Sitting, Standing, Picking up objects, Drinking water, and Fall events. The results showed that the model is capable of recognising most of the activities on real data.
Estrogen Lowers Alzheimer β-Amyloid Generation by Stimulatingtrans-Golgi Network Vesicle Biogenesis*

Estrogen reduces the risk of Alzheimer's disease in post-menopausal women, β-amyloid (Aβ) burden in animal models of Alzheimer's disease, and secretion of Aβ from neuronal cultures. The biological basis for these effects remains unknown. Here, utilizing cell-free systems derived from both neuroblastoma cells and primary neurons, we demonstrate that 17β-estradiol (17β-E2) stimulates formation of vesicles containing the β-amyloid precursor protein (βAPP) from the trans-Golgi network (TGN). Accelerated βAPP trafficking precludes maximal Aβ generation within the TGN. 17β-E2 appears to modulate TGN phospholipid levels, particularly those of phosphatidylinositol, and to recruit soluble trafficking factors, such as Rab11, to the TGN. Together, these results suggest that estrogen may exert its anti-Aβ effects by regulating βAPP trafficking within the late secretory pathway. These results suggest a novel mechanism through which 17β-E2 may act in estrogen-responsive tissues and illustrate how altering the kinetics of the transport of a protein can influence its metabolic fate.
Utility of urine eosinophils in the diagnosis of acute interstitial nephritis.

BACKGROUND AND OBJECTIVES Urine eosinophils (UEs) have been shown to correlate with acute interstitial nephritis (AIN) but the four largest series that investigated the test characteristics did not use kidney biopsy as the gold standard. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This is a retrospective study of adult patients with biopsy-proven diagnoses and UE tests performed from 1994 to 2011. UEs were tested using Hansel's stain. Both 1% and 5% UE cutoffs were compared. RESULTS This study identified 566 patients with both a UE test and a native kidney biopsy performed within a week of each other. Of these patients, 322 were men and the mean age was 59 years. There were 467 patients with pyuria, defined as at least one white cell per high-power field. There were 91 patients with AIN (80% was drug induced). A variety of kidney diseases had UEs. Using a 1% UE cutoff, the comparison of all patients with AIN to those with all other diagnoses showed 30.8% sensitivity and 68.2% specificity, giving positive and negative likelihood ratios of 0.97 and 1.01, respectively. Given this study's 16% prevalence of AIN, the positive and negative predictive values were 15.6% and 83.7%, respectively. At the 5% UE cutoff, sensitivity declined, but specificity improved. The presence of pyuria improved the sensitivity somewhat, with a decrease in specificity. UEs were no better at distinguishing AIN from acute tubular necrosis compared with other kidney diseases. CONCLUSIONS UEs were found in a variety of kidney diseases besides AIN. At the commonly used 1% UE cutoff, the test does not shift pretest probability of AIN in any direction. Even at a 5% cutoff, UEs performed poorly in distinguishing AIN from acute tubular necrosis or other kidney diseases.
Exploring the spectral properties of faint hard X-ray sources with XMM Newton

We present a spectroscopic study of 41 hard X-ray sources detected serendipitously with high significance (>5 in the 2-10 keV band) in seven EPIC performance/verification phase observations. The large collecting area of EPIC allows us to explore the spectral properties of these faint hard X-ray sources with 2< F2 10< 80 10 14 erg cm 2 s 1 even though the length of the exposures are modest (20 ks). Optical identifications are available for 21 sources of our sample. Using a simple power law plus Galactic absorption model we find an average value of the photon index 1.6-1.7, broadly consistent with recent measurements made at similar fluxes with ASCA and with Chandra stacked spectral analyses. We find that 31 out of 41 sources are well fitted by this simple model and only eight sources require absorption in excess of the Galactic value. Interestingly enough, one third of these absorbed sources are broad line objects, though with moderate column densities. Two sources in the sample are X-ray bright optically quiet galaxies and show flat X-ray spectra. Comparing our observational results with those expected from standard synthesis models of the cosmic X-ray background (CXB) we find a fraction of unabsorbed to absorbed sources larger than predicted by theoretical models at our completeness limit of F2 10 5 10 14 erg cm 2 s 1 . T he results presented here illustrate well how wide-angle surveys performed with EPIC on board XMM-Newton allow population studies of interesting and unusual sources to be made as well as enabling constraints to be placed on some input parameters for synthesis models of the CXB.
Anthocyanin-rich extract from Hibiscus sabdariffa calyx counteracts UVC-caused impairments in rats

Abstract Context: Ultraviolet radiation (UV) was reported to cause oxidative stress. Hibiscus sabdariffa L. (Malvaceae) calyx is commonly used in traditional Asian and African medicines and possesses strong antioxidant capacity due to its anthocyanin (ANTH) content. Objective: This study researched the possible protective role of Hibiscus sabdariffa calyx extract (HSCE) in UVC exposure of rats. Material and methods: Levels of serum enzymes, renal function tests, and some oxidant/antioxidant biomarkers of skin, lens, and retina tissues were monitored. Rats were exposed to UVC 4 h daily for 40 d and simultaneously received HSCE containing 2.5, 5, and 10 mg doses of ANTH in drinking water. Results: Significant (p < 0.05) increases in the levels of serum aminotransferases, lactate dehydrogenase, urea, creatinine, and uric acid were noted after UVC exposure. In skin, lens, and retina tissues, total oxidant status, oxidative stress index, lipid peroxidation, and protein oxidation escalated markedly (p < 0.05) whereas total antioxidant status, reduced glutathione, and superoxide dismutase decreased dramatically (p < 0.05) related to UVC. Co-administration of HSCE with each ANTH dose significantly (p < 0.05) reversed aforementioned parameters (except total oxidant status) almost in all tissues. The LD50 of HSCE in rats was determined to be above 5000 mg/kg. Discussion and conclusion: Our data revealed that HSCE has a remarkable potential to counteract UVC-caused impairments, probably through its antioxidant and free radical-defusing effects. Therefore, HSCE could be useful against some cutaneous and ocular diseases in which UV and oxidative stress have a role in the etiopathogenesis.