Miracle-dz/UniFAR-FTUs huggingface dataset:
A Changing Landscape of Physician Quality Reporting: Analysis of Patients’ Online Ratings of Their Physicians Over a 5-Year Period

Background Americans increasingly post and consult online physician rankings, yet we know little about this new phenomenon of public physician quality reporting. Physicians worry these rankings will become an outlet for disgruntled patients. Objective To describe trends in patients’ online ratings over time, across specialties, to identify what physician characteristics influence online ratings, and to examine how the value of ratings reflects physician quality. Methods We used data from RateMDs.com, which included over 386,000 national ratings from 2005 to 2010 and provided insight into the evolution of patients’ online ratings. We obtained physician demographic data from the US Department of Health and Human Services’ Area Resource File. Finally, we matched patients’ ratings with physician-level data from the Virginia Medical Board and examined the probability of being rated and resultant rating levels. Results We estimate that 1 in 6 practicing US physicians received an online review by January 2010. Obstetrician/gynecologists were twice as likely to be rated (P < .001) as other physicians. Online reviews were generally quite positive (mean 3.93 on a scale of 1 to 5). Based on the Virginia physician population, long-time graduates were more likely to be rated, while physicians who graduated in recent years received higher average ratings (P < .001). Patients gave slightly higher ratings to board-certified physicians (P = .04), those who graduated from highly rated medical schools (P = .002), and those without malpractice claims (P = .1). Conclusion Online physician rating is rapidly growing in popularity and becoming commonplace with no evidence that they are dominated by disgruntled patients. There exist statistically significant correlations between the value of ratings and physician experience, board certification, education, and malpractice claims, suggesting a positive correlation between online ratings and physician quality. However, the magnitude is small. The average number of ratings per physician is still low, and most rating variation reflects evaluations of punctuality and staff. Understanding whether they truly reflect better care and how they are used will be critically important.
Analysis of Inflammatory Cytokines in the Tears of Dry Eye Patients

Purpose: To determine the levels of 8 important cytokines and 1 chemokine in tears of patients with dry eye disease. Methods: Tear samples were collected from 7 patients with dry eye disease and 7 healthy volunteers, and impression cytology samples were collected from 3 of the dry eye patients and 3 of the normal controls. Tears were analyzed for the presence of 8 cytokines [interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, IL-1β] and 1 chemokine (IL-8). The cytokines and chemokine in each tear sample were measured using Invitrogen's Multiplex Bead Immunoassays. The impression cytology samples were analyzed for IL-1β, IL-6, IL-8, and TNF-α mRNA expression using real-time reverse transcriptase polymerase chain reaction anlaysis. Results: All cytokines and the chemokine measured were significantly increased in the tears of dry eye patients as compared to normal controls. mRNA of all four markers was increased, and the fold increase correlated well with the fold increase of the cytokine concentration found in the tear samples. Conclusion: Tears from dry eye patients contain significantly increased concentrations of cytokines that show correlation to severity of the disease. The upregulation of their respective genes in the conjunctiva suggests that the concentration increase is not the result of evaporative effects, but of overproduction. These findings suggest that cytokines may play an important role in dry eye disease and topical cytokine modulators may be explored as a therapeutic approach to dry eye disease.
Lc3 Over-Expression Improves Survival and Attenuates Lung Injury Through Increasing Autophagosomal Clearance in Septic Mice

Objective: To clarify the role of autophagy in sepsis-induced lung injury. Background: The role of autophagy as a protective or maladaptive response in lung cells during sepsis has not yet been determined. The lack of specificity of the autophagic process has driven the development of new approaches that assessautophagosomes from formation to fusion with lysosomes. Methods: Sepsis was induced by cecal ligation and puncture (CLP). The autophagic process was manipulated using the pharmacological inhibitors of the autophagy pathway. Green fluorescent protein (GFP)-microtubule-associated protein 1 light chain 3 (LC3) transgenic mice were further used to determine the role of autophagy. Results: The formation of autophagosomal protein LC3-II progressively accumulated in the lungs over 24 hours after CLP, with the Lc3 gene expression returning to baseline levels at 24 hours. Autophagosome-lysosome fusion, however, gradually decreased from 8 to 24 hours after CLP, suggesting impaired clearance of autophagosomes rather than upregulation of autophagy in the septic lung. In contrast, transgenic mice overexpressing the Lc3 gene exhibited increased clearance of autophagosomes and improved survival after CLP. This protective effect was also seen in decreased cell death, inflammatory responses, neutrophil accumulation, albumin leakage, and edema formation. However, blockade of autophagosome-lysosome fusion with bafilomycin A1 abolished the protective effects in transgenic mice. This indicates that Lc3 transgene attenuates lung injury/inflammation in sepsis, possibly through increasing the clearance of autophagosomes. Conclusions: Autophagy in the septic lung represents a protective response. However, autophagy, by virtue of excessive autophagosome accumulation, may play a maladaptive role in the late stage of sepsis, leading to acute lung injury.
False data injection attacks against state estimation in electric power grids

A power grid is a complex system connecting electric power generators to consumers through power transmission and distribution networks across a large geographical area. System monitoring is necessary to ensure the reliable operation of power grids, and state estimation is used in system monitoring to best estimate the power grid state through analysis of meter measurements and power system models. Various techniques have been developed to detect and identify bad measurements, including interacting bad measurements introduced by arbitrary, nonrandom causes. At first glance, it seems that these techniques can also defeat malicious measurements injected by attackers. In this article, we expose an unknown vulnerability of existing bad measurement detection algorithms by presenting and analyzing a new class of attacks, called false data injection attacks, against state estimation in electric power grids. Under the assumption that the attacker can access the current power system configuration information and manipulate the measurements of meters at physically protected locations such as substations, such attacks can introduce arbitrary errors into certain state variables without being detected by existing algorithms. Moreover, we look at two scenarios, where the attacker is either constrained to specific meters or limited in the resources required to compromise meters. We show that the attacker can systematically and efficiently construct attack vectors in both scenarios to change the results of state estimation in arbitrary ways. We also extend these attacks to generalized false data injection attacks, which can further increase the impact by exploiting measurement errors typically tolerated in state estimation. We demonstrate the success of these attacks through simulation using IEEE test systems, and also discuss the practicality of these attacks and the real-world constraints that limit their effectiveness.
Decrease in early right alpha band phase synchronization and late gamma band oscillations in processing syntax in music

The present study investigated the neural correlates associated with the processing of music‐syntactical irregularities as compared with regular syntactic structures in music. Previous studies reported an early (∼200 ms) right anterior negative component (ERAN) by traditional event‐related‐potential analysis during music‐syntactical irregularities, yet little is known about the underlying oscillatory and synchronization properties of brain responses which are supposed to play a crucial role in general cognition including music perception. First we showed that the ERAN was primarily represented by low frequency (<8 Hz) brain oscillations. Further, we found that music‐syntactical irregularities as compared with music‐syntactical regularities, were associated with (i) an early decrease in the alpha band (9–10 Hz) phase synchronization between right fronto‐central and left temporal brain regions, and (ii) a late (∼500 ms) decrease in gamma band (38–50 Hz) oscillations over fronto‐central brain regions. These results indicate a weaker degree of long‐range integration when the musical expectancy is violated. In summary, our results reveal neural mechanisms of music‐syntactic processing that operate at different levels of cortical integration, ranging from early decrease in long‐range alpha phase synchronization to late local gamma oscillations. Hum Brain Mapp 2009. © 2008 Wiley‐Liss, Inc.
Asset Ownership and Contractibility of Interaction

In a property-rights framework, I study how organizational form and quantity contracts interact in generating investment incentives. The model nests standard property-rights and hold-up models as special cases. I admit general message-dependent contracts but provide conditions under which noncontingent contracts are optimal. First, the article contributes to the foundation of the property-rights theory: I characterize under which circumstances its predictions are correct when trade is contractible. Second, I study how the optimal use of the incentive instruments depends on the environment. Finally, the model offers a new perspective on the classic Fisher Body case and produces implications that are empirically testable.
The perceptual evaluation of information systems using the construct of user satisfaction: case study of a large french group

This research work concerns the perceptual evaluation of the performance of information systems (IS) and more particularly, the construct of user satisfaction. Faced with the difficulty of obtaining objective measures for the success of IS, user satisfaction appeared as a substitutive measure of IS performance (DeLone & McLean, 1992). Some researchers have indeed shown that the evaluation of an IS could not happen without an analysis of the feelings and perceptions of individuals who make use of it. Consequently, the concept of satisfaction has been considered as a guarantee of the performance of an IS. Also it has become necessary to ponder the drivers of user satisfaction. The analysis of models and measurement tools for satisfaction as well as the adoption of a contingency perspective has allowed the description of principal dimensions that have a direct or less direct impact on user perceptions.
Losing the Big Picture: How Religion May Control Visual Attention

Despite the abundance of evidence that human perception is penetrated by beliefs and expectations, scientific research so far has entirely neglected the possible impact of religious background on attention. Here we show that Dutch Calvinists and atheists, brought up in the same country and culture and controlled for race, intelligence, sex, and age, differ with respect to the way they attend to and process the global and local features of complex visual stimuli: Calvinists attend less to global aspects of perceived events, which fits with the idea that people's attentional processing style reflects possible biases rewarded by their religious belief system.
Barriers to Client-Centredness and Their Resolution

This research sought to determine which therapist barriers prevent client-centred practice the most, and which methods are perceived as being most effective in resolving therapist barriers. A list of barriers that therapists bring to client-centred practice and methods to resolve these was identified from the literature and formed the basis of a questionnaire sent to 60 occupational therapists in the United Kingdom. The results showed that the therapist and client having different goals was the barrier which most prevented client-centred practice. The high ratings of other statements suggested that the values, beliefs and attitudes of therapists and of the employment culture make client-centred practice uncomfortable to use and hence prevent its implementation. Case examples showing how to practice in a client-centred fashion were rated as the most effective method of barrier removal.
Rethinking the author-reader relationship in computer documentation

he domain of literary theory, inhabited by scholars of poetry, fiction, and belles lettres, may seem far afield from the world of computer documentation, peopled by technical writers, usability experts, and computer pro grammers. But from a rhetorical point of view, these two fields of study and practice appear more similar than not: both are concerned with producing manuals that convey information intended for specific purposes to an audience who is largely unknown to the author and who will use a manual under sometimes unpredictable circumstances and with unforeseen consequences. No matter how much a novelist might think she understands the group her story is intended to reach or how carefully a usability expert has researched her potential users, there is always and inevitably a gap between the actual people who make up the audience for a particular manual and those the author has envisioned. And the dissonance between the responses of the anticipated audience and those of the actual audience can be one of the most frustrating and puzzling parts of a writer's job. Anyone who has heard an audience laugh at a scene when they were supposed to cry or has watched someone misunderstand what seems a clear command in a computer manual has experienced this dissonance up close.
Audiovestibular findings in patients with Vogt-Koyanagi-Harada disease

Abstract Conclusion: The long-term follow-up study revealed a good audiovestibular prognosis in our patients with Vogt-Koyanagi-Harada disease (VKH) after adequate treatment. Objectives: To evaluate the audiovestibular findings and long-term prognosis of patients with VKH. Methods: A total of 82 ears in 41 patients (9 males and 32 females, aged 18–78 years) with VKH were examined in the audiovestibular study. Of the 41 patients, 16 patients with follow-up periods of more than 12 months (13–158 months) were included in the long-term follow-up study. Audiovestibular examinations included pure-tone audiometry; positional, positioning, and spontaneous nystagmus tests; and a caloric test. Results: Among the 41 patients, 28 (68%) complained of auditory symptoms at the initial visit and 28 (68%) showed sensorineural hearing loss (SNHL). Of the 24 patients who underwent nystagmus tests, only 3 (13%) presented with vestibular symptoms whereas 11 (46%) had nystagmus. Among 32 ears in 16 patients enrolled in the long-term follow-up study, 19 ears showed SNHL at the initial visit. The SNHL returned to normal in 14 ears (74%) and remained minimal in severity in the other 5 ears (26%) at the last visit. None of the patients showed persistent or repetitive vestibular symptoms.
Apical membrane Na+/H+ exchange in Necturus gallbladder epithelium. Its dependence on extracellular and intracellular pH and on external Na+ concentration

Intracellular microelectrode techniques and extracellular pH measurements were used to study the dependence of apical Na+/H+ exchange on mucosal and intracellular pH and on mucosal solution Na+ concentration ([Na+]o). When mucosal solution pH (pHo) was decreased in gallbladders bathed in Na(+)-containing solutions, aNai fell. The effect of pHo is consistent with titration of a single site with an apparent pK of 6.29. In Na(+)-depleted tissues, increasing [Na+]o from 0 to values ranging from 2.5 to 110 mM increased aNai; the relationship was well described by Michaelis-Menten kinetics. The apparent Km was 15 mM at pHo 7.5 and increased to 134 mM at pHo 6.5, without change in Vmax. In Na(+)-depleted gallbladders, elevating [Na+]o from 0 to 25 mM increased aNai and pHi and caused acidification of a poorly buffered mucosal solution upon stopping the superfusion; lowering pHo inhibited both apical Na+ entry and mucosal solution acidification. Both effects can be ascribed to titration of a single site; the apparent pK's were 7.2 and 7.4, respectively. Diethylpyrocarbonate (DEPC), a histidine- specific reagent, reduced mucosal acidification by 58 +/- 4 or 39 +/- 6% when exposure to the drug was at pHo 7.5 or 6.5, respectively. Amiloride (1 mM) did not protect against the DEPC inhibition, but reduced both apical Na+ entry and mucosal acidification by 63 +/- 5 and 65 +/- 9%, respectively. In the Na(+)-depleted tissues mean pHi was 6.7. Cells were alkalinized by exposure to mucosal solutions containing high concentrations of nicotine or methylamine. Estimates of apical Na+ entry at varying pHi, upon increasing [Na+]o from 0 to 25 mM, indicate that Na+/H+ exchange is active at pHi 7.4. Intracellular H+ stimulated apical Na+ entry by titration of more than one site (apparent pK 7.1, Hill coefficient 1.7). The results suggest that external Na+ and H+ interact with one site of the Na+/H+ exchanger and that cytoplasmic H+ acts on at least two sites. The external titratable group seems to be an imidazolium, which is apparently different from the amiloride- binding site. The dependence of Na+ entry on pHi supports the notion that the Na+/H+ exchanger is operational under normal transport conditions.
An adaptive workflow coupled with Random Forest algorithm to identify intact N-glycopeptides detected from mass spectrometry

MOTIVATION Despite many attempts for algorithm development in recent years, automated identification of intact glycopeptides from LC-MS(2) spectral data is still a challenge in both sensitivity and precision. RESULTS We implemented a supervised machine learning algorithm, Random Forest, in an automated workflow to identify N-glycopeptides using spectral features derived from ion trap-based LC-MS(2) data. The workflow streamlined high-confident N-glycopeptide spectral data and enabled adaptive model optimization with respect to different sampling strategies, training sample size and feature set. A critical evaluation of the features important for glycopeptide identification further facilitated effective feature selection for model improvement. Using split sample testing method from 577 high-confident N-glycopeptide spectral data, we demonstrated that an optimal true-positive rate, precision and false-positive rate of 73, 88 and 10%, respectively, can be attained for overall N-glycopeptide identification Availability and implementation: The workflow developed in this work and the application suite, Sweet-Heart, that the workflow supports for N-glycopeptide identification are available for download at http://sweet-heart.glycoproteomics. proteome.bc. sinica.edu. tw/.
Necessary and Sufficient Conditions for Deadlock-free Networks

In this paper we develop a new and generic theory about the necessary and sufficient conditions for deadlock-free routing in the interconnection networks An extension of the channel dependency graph described by Dally is defined, the channel dynamic dependency graph. The main achievement of this new concept is consecuence of introducing the concept of time and the flow control function in its definition. Our theory remains valid for different routing and flow control functions showing that even if Duato’s theorem conditions are not fulfilled the network can be deadlock-free. Index Terms Multicomputer networks, deadlock, flow control, routing
An enhanced sensor deployment scheme for automated smart environments

For the wireless sensor network (WSN) to operate successfully, a critical issue is to provide sufficient sensing coverage. In this paper, we target on smart environments and deal with both the homogeneous (having identical sensing radius) and heterogeneous sensors (having different sensing ranges) equipped with locomotion facilities to assist in the sensor self-deployment. An enhanced virtual forces algorithm with boundary forces (EVFA-B) protocol is proposed to realize an automated monitoring network. The EVFA-B mechanism exerts weighted attractive and repulsive forces on each sensor based on predefined distance thresholds. Resultant forces then guide the sensors to their suitable positions with the objective of enhancing the sensing coverage (after a possibly random placement of sensors). To achieve high coverage ratio, we infer that good choices for the associated weight constants greatly depend on sensor population and monitored area size, while independent of sensing radius. Performance of the proposed sensor deployment strategy is evaluated in terms of surveillance coverage and moving energy consumption. We also implement our EVFA-B deployment mechanism in a real-life monitoring network (MoNet) to demonstrate the protocol feasibility.
Subcellular Targeting of Nine Calcium-Dependent Protein Kinase Isoforms from Arabidopsis1

Calcium-dependent protein kinases (CDPKs) are specific to plants and some protists. Their activation by calcium makes them important switches for the transduction of intracellular calcium signals. Here, we identify the subcellular targeting potentials for nine CDPK isoforms from Arabidopsis, as determined by expression of green fluorescent protein (GFP) fusions in transgenic plants. Subcellular locations were determined by fluorescence microscopy in cells near the root tip. Isoforms AtCPK3-GFP and AtCPK4-GFP showed a nuclear and cytosolic distribution similar to that of free GFP. Membrane fractionation experiments confirmed that these isoforms were primarily soluble. A membrane association was observed for AtCPKs 1, 7, 8, 9, 16, 21, and 28, based on imaging and membrane fractionation experiments. This correlates with the presence of potential N-terminal acylation sites, consistent with acylation as an important factor in membrane association. All but one of the membrane-associated isoforms targeted exclusively to the plasma membrane. The exception was AtCPK1-GFP, which targeted to peroxisomes, as determined by covisualization with a peroxisome marker. Peroxisome targeting of AtCPK1-GFP was disrupted by a deletion of two potential N-terminal acylation sites. The observation of a peroxisome-located CDPK suggests a mechanism for calcium regulation of peroxisomal functions involved in oxidative stress and lipid metabolism.