Miracle-dz/UniFAR-FTUs huggingface dataset:
The epidemiology of family meals among Ohio’s adults

Abstract Objective The epidemiology of family meals among adults at a population level is poorly characterized and whether living with children impacts this health behaviour is uncertain. We determined the prevalence of family meals among US adults in a mid-western state whose families did and did not include minor children and described how it varied by sociodemographic characteristics. Design The cross-sectional 2012 Ohio Medicaid Assessment Survey is representative of Ohio adults and included questions on their sociodemographic characteristics and the frequency with which they eat family meals at home. Setting Trained interviewers administered landline and cell phone surveys to adults sampled from Ohio’s non-institutionalized population. Subjects We analysed data from 5766 adults living with minor children and 8291 adults not living alone or with children. Results The prevalence of family meals was similar for adults who did and did not live with minor children: 47 % (95 % CI 46, 49 %) of adults living with and 51 % (95 % CI 50, 53 %) of adults living without children reported eating family meals on most (six or seven) days of the week. Family meal frequency varied by race/ethnicity, marital and employment status in both groups. Non-Hispanic African-American adults, those who were not married and those who were employed ate family meals less often. Conclusions Adults in Ohio frequently shared meals with their family and family meal frequency was not strongly related to living with children. Broadening the scope of future studies to include adults who are not parents could enhance our understanding of the potential health benefits of sharing meals.
An area-efficient network interface for a TDM-based Network-on-Chip

Network interfaces (NIs) are used in multi-core systems where they connect processors, memories, and other IP-cores to a packet switched Network-on-Chip (NOC). The functionality of a NI is to bridge between the read/write transaction interfaces used by the cores and the packet-streaming interface used by the routers and links in the NOC. The paper addresses the design of a NI for a NOC that uses time division multiplexing (TDM). By keeping the essence of TDM in mind, we have developed a new area-efficient NI micro-architecture. The new design completely eliminates the need for FIFO buffers and credit based flow control - resources which are reported to account for 50–85% of the area in existing NI designs. The paper discusses the design considerations, presents the new NI micro-architecture, and reports area figures for a range of implementations.
Impact of an electronic antibiotic advice and approval system on antibiotic prescribing in an Australian teaching hospital

The impact of a computer‐based infectious diseases electronic antibiotic advice and approval system (“IDEA3S”) was assessed as an alternative to a labour‐intensive, phone‐based approval system. IDEA3S‐based approvals replaced 48% of all approvals for the most frequently requested antimicrobial agents (ceftriaxone/cefotaxime, vancomycin) and were associated with stable overall rates of antimicrobial use. Antibiotic prescribing for community‐acquired pneumonia was 76% concordant with IDEA3S recommendations, and clinical acceptance of IDEA3S was excellent. Successful implementation required a coordinated, evidence‐based approach between clinicians, pharmacists and hospital administration, together with ongoing staff education and feedback of results. IDEA3S is a useful new adjunct to routine clinician consultation to support appropriate antibiotic prescribing for a number of common indications in hospitals.
Advanced Economic Control of Electricity-Based Space Heating Systems in Domestic Coalitions with Shared Intermittent Energy Resources

Over the past few years, Domestic Heating Automation Systems (DHASs) that optimize the domestic space heating control process with minimum user input, utilizing appropriate occupancy prediction technology, have emerged as commercial products (e.g., the smart thermostats from Nest and Honeywell). At the same time, many houses are being equipped with, potentially grid-connected, Intermittent Energy Resources (IERs), such as rooftop photovoltaic systems and/or small wind turbine generators. Now, in many regions of the world, such houses can sell energy to the grid but at a lower price than the price of buying it. In this context, and given the anticipated increase in electrification of heating, the next generation DHASs need to incorporate Advanced Economic Control (AEC). Such AEC can exploit the energy buffer that heating loads provide, in order to shift the consumption of electricity-based heating systems to follow the intermittent energy generation of the house. By so doing, the energy imported from the grid can be minimized and considerable monetary gains for the household can be achieved, without affecting the occupants’ schedule. These benefits can be amplified still further in domestic coalitions, where a number of houses come together and share their IER generation to minimize their cumulative grid energy import. Given the above, in this work we extend a state-of-the-art DHAS, to propose AdaHeat+, a practical DHAS, that, for the first time, incorporates AEC. Our work is applicable to both individual houses and domestic coalitions and comes complete with an allocation mechanism to share the coalition gains. Importantly, we propose an effective heuristic heating schedule planning approach for collective AEC that (i) has a complexity that scales in a linear and parallelizable manner with the coalition size, and (ii) enables AdaHeat+ to handle the distinct preferences, in balancing heating cost and thermal discomfort, of the households. Our approach relies on stochastic IER power output predictions. In this context, we propose a simple and effective formulation for the site-specific calibration of such predictions based on adaptive Gaussian process modeling. Finally, we demonstrate the effectiveness of AdaHeat+ through real data evaluation, to show that collective AEC can improve heating cost-efficiency by up to 60%, compared to independent AEC (and even more when compared to no-AEC).
Preventive effect of methanolic extract of Zataria Multiflora Boiss on liver toxicity of paracetamol in rats

Background: The analgesic paracetamol causes a potentially fatal, centrilobular hepatic necrosis when taken in misuse and overdose. This research aimed to evaluate the protective effects of methanolic extract of Zataria Multiflora Boiss (Z. Multiflora) against hepatic damage induced by paracetamol-induced hepatotoxicity in male Wistar rats. Methods: for this purpose, paracetamol was administrated orally at a dose of 2 g/ kg body weight (b.w.)/ day on the seventh day after the oral administration of a methanolic extract of Z. Multiflora at doses of 100 mg/ kg, 200 mg/ kg and 400 mg/ kg b.w. The lipid peroxidation level and activities of liver aminotransferases and enzymes contributing to the oxidative damage were measured in serum, and a histopathological examination of liver sections was also performed. Results and Discussion: The results showed that Z. Multiflora reduced the activity of aminotransferases in rats treated with paracetamol. This extract also inhibited lipid peroxidation and protein carbonylation by an increase in the activity of the antioxidant enzyme and the elevation of glutathione content of the liver. Conclusion: These effects are related to the antioxidant compounds of Z. Multiflora. The methanolic extract of this herb exhibits protective effects against paracetamol-induced hepatotoxicity.
Clinical Profile, Etiology and Therapeutic Outcome in 324 Hepatocellular Carcinoma Patients at a Tertiary Care Center in India

Objective: To study the profile and outcome of therapy for hepatocellular carcinoma (HCC) in India. Methods: Data analysis of HCC patients enrolled in liver clinic between 1990 and 2005. Results: We registered 324 HCC patients [males 284 (88%), mean age 52.4 ± 13.1 years]. The etiology of HCC was: hepatitis B virus 165 (51%), hepatitis C virus 38 (12%), alcohol 20 (6%), combined 31 (10%) and unknown 70 (21%). Serum α-fetoprotein was >400 ng in 36%, portal vein invasion was seen in 40% and distant metastases in 13%. Therapy was offered to 141 (43.5%) patients, but survival data was available in only 130 (93%) of them. Treatment given and median survival time was as follows: surgical resection, 19 months (n = 14); transarterial chemoembolization, 11 months (n = 23); transarterial rhenium therapy, 26 months (n = 7); radiofrequency ablation, 24 months (n = 4); acetic acid ablation, 13 months (n = 17); oral chemotherapy, 26 months (n = 33), and combination therapy, 26 months (n = 32). Vascular invasion, Okuda staging and therapy were independent factors associated with survival. Treated patients had longer median survival compared to untreated ones (16 months vs. 7 months, p < 0.05). Conclusions: Hepatitis B infection is the predominant cause of HCC in India. Serum α-fetoprotein was diagnostic in only one third of our patients. Most patients present late, when curative therapies are not possible. Treated patients had better survival than untreated ones.
Mycotoxin production by fusarium species isolated from bananas

The ability of Fusarium species isolated from bananas to produce mycotoxins was studied with 66 isolates of the following species: F. semitectum var. majus (8 isolates), F. camptoceras (3 isolates), a Fusarium sp. (3 isolates), F. moniliforme (16 isolates), F. proliferatum (9 isolates), F. subglutinans (3 isolates), F. solani (3 isolates), F. oxysporum (5 isolates), F. graminearum (7 isolates), F. dimerum (3 isolates), F. acuminatum (3 isolates), and F. equiseti (3 isolates). All isolates were cultured on autoclaved corn grains. Their toxicity to Artemia salina L. larvae was examined. Some of the toxic effects observed arose from the production of known mycotoxins that were determined by thin-layer chromatography, gas chromatography, or high-performance liquid chromatography. All F. camptoceras and Fusarium sp. isolates proved toxic to A. salina larvae; however, no specific toxic metabolites could be identified. This was also the case with eight isolates of F. moniliforme and three of F. proliferatum. The following mycotoxins were encountered in the corn culture extracts: fumonisin B(inf1) (40 to 2,900 (mu)g/g), fumonisin B(inf2) (150 to 320 (mu)g/g), moniliformin (10 to 1,670 (mu)g/g), zearalenone (5 to 470 (mu)g/g), (alpha)-zearalenol (5 to 10 (mu)g/g), deoxynivalenol (8 to 35 (mu)g/g), 3-acetyldeoxynivalenol (5 to 10 (mu)g/g), neosolaniol (50 to 180 (mu)g/g), and T-2 tetraol (5 to 15 (mu)g/g). Based on the results, additional compounds produced by the fungal isolates may play prominent roles in the toxic effects on larvae observed. This is the first reported study on the mycotoxin-producing abilities of Fusarium species that contaminate bananas.
New dimensions in the quantitative classification of mental illness.

CONTEXT Patterns of comorbidity among mental disorders are thought to reflect the natural organization of mental illness. Factor analysis can be used to investigate this structure and construct a quantitative classification system. Prior studies identified 3 dimensions of psychopathology: internalizing, externalizing, and thought disorder. However, research has largely relied on common disorders and community samples. Consequently, it is unclear how well the identified organization applies to patients and how other major disorders fit into it. OBJECTIVE To analyze comorbidity among a wide range of Axis I disorders and personality disorders (PDs) in the general outpatient population. DESIGN Clinical cohort study. SETTING A general outpatient practice, the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project. PARTICIPANTS Outpatients (N = 2900) seeking psychiatric treatment. MAIN OUTCOME MEASURES The Structured Clinical Interview for DSM-IV and the Structured Interview for DSM-IV Personality. RESULTS We tested several alternative groupings of the 25 target disorders. The DSM-IV organization fit the data poorly. The best-fitting model consisted of 5 factors: internalizing (anxiety and eating disorders, major depressive episode, and cluster C, borderline, and paranoid PDs), externalizing (substance use disorders and antisocial PD), thought disorder (psychosis, mania, and cluster A PDs), somatoform (somatoform disorders), and antagonism (cluster B and paranoid PDs). CONCLUSIONS We confirmed the validity of the 3 previously found spectra in an outpatient population. We also found novel somatoform and antagonism dimensions, which this investigation was able to detect because, to our knowledge, this is the first study to include a variety of somatoform and personality disorders. The findings suggest that many PDs can be placed in Axis I with related clinical disorders. They also suggest that unipolar depression may be better placed with anxiety disorders than with bipolar disorders. The emerging quantitative nosology promises to provide a more useful guide to clinicians and researchers.
Do repressors differ on indirect and direct measures of attributional style?

We investigated whether individuals who possess a repressive coping style (repressors) differ in their attributional style depending on how it was assessed. Whereas repressors rated hypothetical negative events to be less likely to be due to internal causes compared to nonrepressors on a direct measure, the opposite pattern was found on an indirect measure, with repressors rating hypothetical negative events to be significantly more likely to be due to internal causes. It is argued that exclusive reliance on direct self-report methods is not a satisfactory way of eliciting information from repressors. Furthermore, we suggest that repressors may have a similar underlying attributional style to depressed individuals, although this may be expressed differently.
Role for CD47-SIRPα signaling in xenograft rejection by macrophages

We have previously proven that human macrophages can phagocytose porcine cells even in the absence of Ab or complement opsonization, indicating that macrophages present a pivotal immunological obstacle to xenotransplantation. A recent report indicates that the signal regulatory protein (SIRP)α is a critical immune inhibitory receptor on macrophages, and its interaction with CD47, a ligand for SIRPα, prevents autologous phagocytosis. Considering the limited compatibility (73%) in amino acid sequences between pig and human CD47, we hypothesized that the interspecies incompatibility of CD47 may contribute to the rejection of xenogeneic cells by macrophages. In the present study, we have demonstrated that porcine CD47 does not induce SIRPα tyrosine phosphorylation in human macrophage-like cell line, and soluble human CD47-Fc fusion protein inhibits the phagocytic activity of human macrophages toward porcine cells. In addition, we have verified that manipulation of porcine cells for expression of human CD47 radically reduces the susceptibility of the cells to phagocytosis by human macrophages. These results indicate that the interspecies incompatibility of CD47 significantly contributes to the rejection of xenogeneic cells by macrophages. Genetic induction of human CD47 on porcine cells could provide inhibitory signaling to SIRPα on human macrophages, providing a novel approach to preventing macrophage-mediated xenograft rejection.
Achieving work-life balance: Current theoretical and practice issues

Professor Steven Poelmans is a leading international expert on the frontiers of work–family research contributing to theoretical and practice advancements. He is the Academic Director of the International Centre of Work and Family (ICWF) at IESE Business School in Barcelona, Spain, which has worked for more than a decade with numerous organisations in Spain, Latin-America, and various countries around the globe to create a family-responsible environment. In this conversation, Steven Poelmans responds to questions from Thomas Kalliath and Paula Brough (Guest Editors) on a range of theoretical and practice issues currently facing the field including measurement of work–life balance, work–life balance theory, engagement with industry, the role of organisational culture and strategic management in influencing work–life balance.
Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials.

BACKGROUND Antifracture efficacy with supplemental vitamin D has been questioned by recent trials. METHODS We performed a meta-analysis on the efficacy of oral supplemental vitamin D in preventing nonvertebral and hip fractures among older individuals (> or =65 years). We included 12 double-blind randomized controlled trials (RCTs) for nonvertebral fractures (n = 42 279) and 8 RCTs for hip fractures (n = 40 886) comparing oral vitamin D, with or without calcium, with calcium or placebo. To incorporate adherence to treatment, we multiplied the dose by the percentage of adherence to estimate the mean received dose (dose x adherence) for each trial. RESULTS The pooled relative risk (RR) was 0.86 (95% confidence interval [CI], 0.77-0.96) for prevention of nonvertebral fractures and 0.91 (95% CI, 0.78-1.05) for the prevention of hip fractures, but with significant heterogeneity for both end points. Including all trials, antifracture efficacy increased significantly with a higher dose and higher achieved blood 25-hydroxyvitamin D levels for both end points. Consistently, pooling trials with a higher received dose of more than 400 IU/d resolved heterogeneity. For the higher dose, the pooled RR was 0.80 (95% CI, 0.72-0.89; n = 33 265 subjects from 9 trials) for nonvertebral fractures and 0.82 (95% CI, 0.69-0.97; n = 31 872 subjects from 5 trials) for hip fractures. The higher dose reduced nonvertebral fractures in community-dwelling individuals (-29%) and institutionalized older individuals (-15%), and its effect was independent of additional calcium supplementation. CONCLUSION Nonvertebral fracture prevention with vitamin D is dose dependent, and a higher dose should reduce fractures by at least 20% for individuals aged 65 years or older.
MAGNIFICATION BY GALAXY GROUP DARK MATTER HALOS

We report on the detection of gravitational lensing magnification by a population of galaxy groups, at a significance level of 4. 9σ. Using X-ray-selected groups in the COSMOS 1.64 deg2 field, and high-redshift Lyman break galaxies as sources, we measure a lensing-induced angular cross-correlation between the samples. After satisfying consistency checks that demonstrate we have indeed detected a magnification signal, and are not suffering from contamination by physical overlap of samples, we proceed to implement an optimally weighted cross-correlation function to further boost the signal to noise of the measurement. Interpreting this optimally weighted measurement allows us to study properties of the lensing groups. We model the full distribution of group masses using a composite-halo approach, considering both the singular isothermal sphere and Navarro–Frenk–White profiles, and find our best-fit values to be consistent with those recovered using the weak-lensing shear technique. We argue that future weak-lensing studies will need to incorporate magnification along with shear, both to reduce residual systematics and to make full use of all available source information, in an effort to maximize scientific yield of the observations.
Internal Consistency of the Group Environment Questionnaire Modified for An Exercise Setting

The Group Environment Questionnaire—an instrument used to assess cohesiveness in sport teams since 1985—has been modified and used in fitness classes. The purpose of the study was to assess whether the internal consistency values of the modified version are similar to those reported for sport teams. For two samples of participants in exercise classes, the Cronbach alphas for the Attractions to Group Task and Social subtests and for Group Integration Task and Social subtests were . 78, . 61, . 71, and . 78 (n = 290) and . 77, . 62, . 71, and . 77 (n = 198), respectively. These values are highly similar to those reported for the original version.
An initial examination of Singaporean seventh and eighth graders’ views of nature of science

Background and purpose Research in nature of science (NOS) among Asia-Pacific countries such as Singapore is arguably scarce. This study aimed to survey Singaporean secondary school students’ views of NOS with a newly developed instrument named Students’ Views of Nature of Science (SVNOS), which included various key aspects of NOS that are generally agreed upon by the science education community. Moreover, the relations between some demographic factors, including gender and grade, and students’ views of NOS were explored. Sample, design and method In total, 359 Singaporean seventh and eighth graders were invited to participate in this survey. The reliability, validity and structure of the SVNOS instrument were ensured by confirmatory factor analysis. A two-way multivariate analysis of variance was then conducted to determine the interaction effects between the gender variable and the grade-level variable. Results and conclusion The results indicated that the SVNOS instrument is reliable and valid to assess students’ views of NOS regarding seven distinct NOS dimensions. The male students were more prone to have constructivist-oriented views of NOS in the most of the SVNOS dimensions, while the female students conveyed more non-objective views of NOS. In addition, the eighth graders revealed more empiricist-oriented views of NOS than the seventh graders in several SVNOS dimensions. This result seems to contradict the results of previous studies that students’ views of NOS may reflect a developmental trend with their increasing educational experiences.
Screening for Toxic Amyloid in Yeast Exemplifies the Role of Alternative Pathway Responsible for Cytotoxicity

The relationship between amyloid and toxic species is a central problem since the discovery of amyloid structures in different diseases. Despite intensive efforts in the field, the deleterious species remains unknown at the molecular level. This may reflect the lack of any structure-toxicity study based on a genetic approach. Here we show that a structure-toxicity study without any biochemical prerequisite can be successfully achieved in yeast. A PCR mutagenesis of the amyloid domain of HET-s leads to the identification of a mutant that might impair cellular viability. Cellular and biochemical analyses demonstrate that this toxic mutant forms GFP-amyloid aggregates that differ from the wild-type aggregates in their shape, size and molecular organization. The chaperone Hsp104 that helps to disassemble protein aggregates is strictly required for the cellular toxicity. Our structure-toxicity study suggests that the smallest aggregates are the most toxic, and opens a new way to analyze the relationship between structure and toxicity of amyloid species.
Using the timely computing base for dependable QoS adaptation

In open and heterogeneous environments, where an unpredictable number of applications compete for a limited amount of resources, executions can be affected by also unpredictable delays, which may not even be bounded. Since many of these applications have timeliness requirements, they can only be implemented if they are able to adapt to the existing conditions. We present a novel approach, called dependable QoS adaptation, which can only be achieved if the environment is accurately and reliably observed. Dependable QoS adaptation is based on the timely computing base (TCB) model. The TCB model is a partial quality of service synchrony model that adequately characterizes environments of uncertain synchrony and allows, at the same time, the specification and verification of timeliness requirements. We introduce the coverage stability property and show that adaptive applications can use the TCB to dependably adapt and enjoy this property. We describe the characteristics and the interface of a QoS coverage service and discuss its implementation details.