Miracle-dz/UniFAR-FTUs huggingface dataset:
Building recovery ready communities: the recovery ready ecosystem model and community framework

Abstract Background: Public and private systems in the United States and around the World are impacted by substance use disorders (SUD). Despite recent attempts at bringing top down solutions, SUDs continue to be a leading cause of death, a leading correlate in violent crime, and a leading cause of lost productivity in the workplace. Community-based resources have been shown to positively affect SUD impact and SUD recovery, by orienting stakeholders towards the problem and creating continuity among support services. Community-based innovations, such as recovery community organizations and other recovery support services, have provided evidence of successfully scaling recovery efforts and improving the chance of sustained recovery for individuals that live within the community. Methods: A theoretical model and framework, grounded in the recovery-oriented systems of care (ROSC) theorems, is proposed to identify components and connections that support a community’s ability to support individual and group recovery from SUD. Results: The Recovery Ready Ecosystem Model (RREM) and Recovery Ready Community Framework builds upon the early work of the ROSC, highlighting recently emboldened support structures such as harm reduction, educational recovery programs, and other traditional support structures in communities. Conclusions: Enhanced community needs assessment can be informed by the RREM and Recovery Ready Community framework to identify gaps in their current community infrastructure. Further testing of the recovery readiness equation should be performed as a potential measure of efficacy of community ability to support long-term recovery from SUD. Exploration of potential application of the model and framework to international settings is also needed.
GIS-based evaluation of groundwater vulnerability in the Russeifa area, Jordan

In recent years, groundwater quality has been deteriorating in many parts of Jordan as result of agriculture expansion, solid waste disposal, and industrialization. A preliminary assessment of vulnerability to groundwater contamination in Russeifa watershed area was undertaken because of the presence of the largest solid waste disposal site in Jordan, which is known as Russeifa landfi ll. The major geological and hydrogeological factors that affect and control groundwater contamination were incorporated into the DRASTIC model, to produce groundwater vulnerability and risk maps. Moreover, a Geographical Information System (GIS) was used to create a groundwater vulnerability map by overlaying the available hydrogeological data. The fi nal DRASTIC index indicated that the area surrounding the Russeifa landfi ll is highly vulnerable to groundwater contamination.
Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease

Skeletal muscle atrophy and impaired muscle function are associated with lower health-related quality of life, and greater disability and mortality risk in those with chronic kidney disease (CKD). However, the pathogenesis of skeletal dysfunction in CKD is unknown. We used a slow progressing, naturally occurring, CKD rat model (Cy/+ rat) with hormonal abnormalities consistent with clinical presentations of CKD to study skeletal muscle signaling. The CKD rats demonstrated augmented skeletal muscle regeneration with higher activation and differentiation signals in muscle cells (i.e. lower Pax-7; higher MyoD and myogenin RNA expression). However, there was also higher expression of proteolytic markers (Atrogin-1 and MuRF-1) in CKD muscle relative to normal. CKD animals had higher indices of oxidative stress compared to normal, evident by elevated plasma levels of an oxidative stress marker, 8-hydroxy-2' -deoxyguanosine (8-OHdG), increased muscle expression of succinate dehydrogenase (SDH) and Nox4 and altered mitochondria morphology. Furthermore, we show significantly higher serum levels of myostatin and expression of myostatin in skeletal muscle of CKD animals compared to normal. Taken together, these data show aberrant regeneration and proteolytic signaling that is associated with oxidative stress and high levels of myostatin in the setting of CKD. These changes likely play a role in the compromised skeletal muscle function that exists in CKD.
Improving BitTorrent Network's Performance via Deploying Helpers

This paper presents a study on how to increase the BitTorrent Networkpsilas performance via deploying Helpers by modeling, simulating and analyzing. We first define some high-bandwidth, high-connection and controllable super nodes as Helpers, and then try to find the best way to deploy them. Unlike other researchers, we focus on combining the advantages of both multi-server systems and BitTorrent Systems. Our main findings includes: (1) Deploying Helpers into BitTorrent Systems can distinctly enhance the system performance until the overall uploading bandwidth is no longer the constraint condition. (2) After deploying Helpers, the system can present resistance against selfish peers. (3) We can dynamically change the content of Helpers to serve the ever-changing hot torrents and make it only serve charged peers or local peers from economic angle.
Teachers’ Perceptions of Professional Learning Communities as Opportunities For Promoting Professional Growth

Teachers are the focal point for institutionalizing sustainable educational reform. The pivotal point of educational reform revolves around the opportunities for professional growth of teachers. For many schools, the implementation of professional learning communities is serving as the road map for creating opportunities for effective professional growth. This qualitative study was designed to investigate teachers’ perceptions of professional learning communities as opportunities for substantiated ongoing and effective professional growth. The study’s methodology applied the use of focus groups, individual interviews, and participant observations. The findings endorsed that the teachers involved in this study did perceive professional learning communities as a framework and foundation for promoting and sustaining ongoing, effective professional growth.
Cost-cognizant Test Case Prioritization

Test case prioritization techniques schedule test cases for regression testing in an order that increases their ability to meet some performance goal. One performance goal, rate of fault detection, measures how quickly faults are detected within the testing process. Previous work has provided a metric, AP F D, for measuring rate of fault detection, and techniques for prioritizing test cases in order to improve AP F D. This metric and these techniques, however, assume that all test case and fault costs are uniform. In practice, test case and fault costs can vary, and in such cases the previous AP F D metric and techniques designed to improve AP F D can be unsatisfactory. This paper presents a new metric for assessing the rate of fault detection of prioritized test cases, AP F DC, that incorporates varying test case and fault costs. The paper also describes adjustments to previous prioritization techniques that allow them, too, to be \cognizant" of these varying costs. These techniques enable practitioners to perform a new type of prioritization: cost-cognizant test case prioritization. Finally, the results of a formative case study are presented. This study was designed to investigate the cost-cognizant metric and techniques and how they compare to their non-cost-cognizant counterparts. The study’s results provide insights regarding the use of cost-cognizant test case prioritization in a variety of real-world settings.
Tolerance to exercise intensity modulates pleasure when exercising in music: The upsides of acoustic energy for High Tolerant individuals

Moderate physical activity can be experienced by some as pleasurable and by others as discouraging. This may be why many people lack sufficient motivation to participate in the recommended 150 minutes of moderately intense exercise per week. In the present study, we assessed how pleasure and enjoyment were modulated differently by one’s tolerance to self-paced physical activity. Sixty-three healthy individuals were allocated to three independent experimental conditions: a resting condition (watching TV), a cycling in silence condition, and a cycling in music condition. The tolerance threshold was assessed using the PRETIE-Questionnaire. Physical activity consisted in cycling during 30 minutes, at an intensity perceived as “somewhat difficult” on the Ratings of Perceived Exertion Scale. While controlling for self-reported physical activity level, results revealed that for the same perception of exertion and a similar level of enjoyment, the High Tolerance group produced more power output than the Low Tolerance group. There was a positive effect of music for High Tolerant individuals only, with music inducing greater power output and more pleasure. There was an effect of music on heart rate frequency in the Low Tolerant individuals without benefits in power output or pleasure. Our results suggest that for Low Tolerant individuals, energizing environments can interfere with the promised (positive) distracting effects of music. Hence, tolerance to physical effort must be taken into account to conceive training sessions that seek to use distracting methods as means to sustain pleasurable exercising over time.
Screening for congenital cytomegalovirus infection using newborn urine samples collected on filter paper: feasibility and outcomes from a multicentre study

Background As congenital cytomegalovirus (CMV) infection causes significant clinical consequences not only at birth but also later as neurological sequelae, it is critical to establish a strategy for screening congenitally infected newborns. Previous studies have identified an insufficient sensitivity in screening methods based on the use of dried blood spots (DBSs). Objectives To evaluate the feasibility of the authors' recently developed method for large-scale screening for congenital CMV infection and to identify risk factors for congenital infection. Methods More than 21 000 newborns were enrolled at 25 sites in six geographically separate areas of Japan. Urine was collected onto filter cards placed in the diapers, which were then analysed by quantitative PCR using the filter disc directly as a template. Clinical and physical findings of the newborns were extracted from their medical records. CMV strains from the cases and their siblings were genetically compared. Viral loads in DBSs obtained from some of the cases were compared with those in the urine filters. Results Congenital CMV infection was identified in 0.31% (95% CI 0.24% to 0.39%) of the newborns, and 30% of the cases (20/66) had typical clinical manifestations and/or showed abnormalities in brain images at birth. Although the positive predictive value of our screening was 94%, the lack of any comparison with a gold standard assay prevented calculation of the negative predictive value. Almost two-thirds of the cases had siblings, a significantly higher frequency than for uninfected newborns. Most of the cases (21/25) excreted CMV strains identical to those of their siblings. CMV DNA was undetectable in three out of 12 retrievable DBS specimens. Conclusions Implementation of an effective large-scale screening programme for congenital CMV infection is feasible. Siblings are the major risk factor for congenital CMV infection, which emphasises the need for education of mothers-to-be as well as vaccine development.
C-reactive protein in the prediction of rheumatoid arthritis in women.

BACKGROUND The purpose of this study was to examine whether levels of C-reactive protein (CRP), a sensitive marker of disease activity in rheumatoid arthritis (RA), are associated with increased risk of subsequent RA. METHODS Eligible subjects were 39 876 healthy women from the Women's Health Study, a completed randomized trial of aspirin and vitamin E in cardiovascular disease and cancer prevention, begun in 1992. We included 27 939 women who provided blood samples at baseline that could be assayed for CRP. RESULTS During 9.9 years of follow-up, 398 women reported a new diagnosis of RA. Of these, 90 cases were confirmed on medical chart review using American College of Rheumatology criteria. In age-adjusted analysis, the relative risks for developing confirmed, incident RA associated with increasing tertiles of CRP (first, second, and third) were 1.00 (reference value), 0.94 (0.54-1.61), and 1.29 (0.78-2.12) (P = .30 for trend). Further adjustment for randomized treatment, age, body mass index, and smoking demonstrated corresponding relative risks of 1.00 (reference value), 0.95 (0.55-1.65), and 1.33 (0.77-2.30) (P = .48 for trend). When we examined whether CRP levels predicted incident RA within 4 years, between 5 to 8 years, and 9 or more years after CRP measurement, we found no significant associations for any time period. CONCLUSIONS In this prospective study of healthy women, a single CRP level did not predict increased risk of RA. Furthermore, CRP measurement closer to the time of diagnosis was not predictive. The consistency of this effect throughout different time periods from diagnosis suggests that CRP does not have a large effect in predicting incident RA.
INTEGRAL and Swift/XRT observations of IGR J16460+0849 (Research Note)

Aims. IGR J16460+0849 is reported in the 3rd IBIS catalog with the shortest exposure of about 11 ks among all the detected sources, which makes it the most interesting target to be investigated with a deeper exposure. The currently available data have increased to an exposure time of a few hundred ks. This stimulates us to investigate the source again by using all the available data. Methods. We analyze all available observations carried out by the International Gamma-Ray Astrophysics Laboratory ( INTEGRAL) on the unidentified source IGR J16460+0849. The data were processed by using the latest version OSA 7.0. In addition we analyze also all the available Swift/XRT data on this source. Results. We find that IGR J16460+0849 has a detection significance of similar to 4.4 sigma in the 20-100 keV band during the observational period between March 2003 and September 2004, when it was exposed by similar to 19 ks. Thereafter the source was not detected anymore, despite an additional exposure of similar to 271 ks. This suggests a flux variability on a timescale of years. The spectral analysis shows that the IBIS/ISGRI data are well presented by a power-law shape, with a photon index obtained as 1.45 +/- 0.86. So far, the source has been detected consistently by IBIS/ISGRI in the subsequent observations and in the adjacent energy bands. We have analyzed the Swift/XRT observations on IGR J16460+0849 as well, and found no source inside the IBIS/ISGRI error circle. The non-detection during the Swift/XRT observation is consistent with the source having a variable nature.
Dimension Distortion by Sobolev Mappings in Foliated Metric Spaces

Abstract We quantify the extent to which a supercritical Sobolev mapping can increase the dimension of subsets of its domain, in the setting of metric measure spaces supporting a Poincaré inequality. We show that the set of mappings that distort the dimensions of sets by the maximum possible amount is a prevalent subset of the relevant function space. For foliations of a metric space X defined by a David–Semmes regular mapping Π : X → W, we quantitatively estimate, in terms of Hausdorff dimension in W, the size of the set of leaves of the foliation that are mapped onto sets of higher dimension. We discuss key examples of such foliations, including foliations of the Heisenberg group by left and right cosets of horizontal subgroups.
Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function

In checkpoint-deficient cells, DNA double-strand breaks (DSBs) are produced during replication by the structure-specific endonuclease MUS81. The mechanism underlying MUS81-dependent cleavage, and the effect on chromosome integrity and viability of checkpoint deficient cells is only partly understood, especially in human cells. Here, we show that MUS81-induced DSBs are specifically triggered by CHK1 inhibition in a manner that is unrelated to the loss of RAD51, and does not involve formation of a RAD51 substrate. Indeed, CHK1 deficiency results in the formation of a RAD52-dependent structure that is cleaved by MUS81. Moreover, in CHK1-deficient cells depletion of RAD52, but not of MUS81, rescues chromosome instability observed after replication fork stalling. However, when RAD52 is down-regulated, recovery from replication stress requires MUS81, and loss of both these proteins results in massive cell death that can be suppressed by RAD51 depletion. Our findings reveal a novel RAD52/MUS81-dependent mechanism that promotes cell viability and genome integrity in checkpoint-deficient cells, and disclose the involvement of MUS81 to multiple processes after replication stress.
Strategies to facilitate the integration of Hispanic migrants in a tourism-dependent community

ABSTRACT Tourism employers and tourism-dependent communities have come to rely on migrants to fill the considerable labor needs of the tourism industry. However, migrants are not always well integrated into the communities that they support, leaving them, the tourism industry, and tourism-dependent communities vulnerable. Set in a community where migrants have been welcomed and well integrated this study utilized in-depth interviews and focus groups with migrants, residents, tourism business owners, and policymakers to identify strategies that have helped Hispanic migrants integrate into a tourism-dependent community. Analysis of this qualitative data was guided by the social exclusion framework. This analysis revealed how economic, social, political, and cultural dimensions play a role in migrants’ integration into the community. The findings reveal the importance of applying a multidimensional approach to integrating migrants into tourism-dependent communities—e.g. language, an element of the social dimension, facilitated activities related to the political dimension. Based upon these findings multiple strategies for integrating migrants into tourism-dependent communities are presented. These strategies move the literature beyond a descriptive identification of the challenges migrants face in integrating into tourism-dependent communities. Such strategies provide opportunities for tourism-dependent communities to improve the well-being of the tourism industry through the well-being of migrants.
Observed Characteristics of the MJO Relative to Maximum Rainfall

Abstract This study examines various dynamical and thermodynamical processes that characterize the Madden–Julian oscillation (MJO). Episodes of deep convection related to the MJO based on rainfall data from the Tropical Rainfall Measuring Mission (TRMM) satellite and the Global Precipitation Climatology Project (GPCP) are identified. Although broad convective envelopes are located utilizing spectrally filtered precipitation, analyses of the features within the envelopes are carried out using unfiltered rainfall and 40-yr ECMWF Re-Analysis (ERA-40) fields. The events are composited and categorized based on geographic location and relative intensity. The composited fields illustrate that, prior to the onset of deep convection, shallow cumulus and cumulus congestus clouds are actively involved in vertical convective transport of heat and moisture. Drying, first accomplished immediately following deep convection in the lower troposphere, is associated with an enhanced horizontal (westerly) advective component.
Prospective 12-month functional and vocational outcomes of hip arthroscopy for femoroacetabular impingement as part of an evidence-based hip pain rehabilitation pathway in an active military population

Background Femoroacetabular impingement (FAI) is common with an estimated prevalence of 10–15% among young active individuals. The natural history of the disorder is progression to early osteoarthritis. Hip arthroscopy is recommended if conservative treatments fail; however, outcomes are unclear, particularly in highly active populations. Aim To evaluate the functional and vocational outcome of hip arthroscopy, as part of an evidence-based rehabilitation hip pain pathway, for the treatment of FAI in an active military population. Methods All patients in the defence rehabilitation hip pain pathway, with a confirmed diagnosis of FAI who failed conservative treatment, were assessed prior to surgery and at 2, 6 and 12 months postsurgery. Outcome measures included the Visual Analogue Scale (VAS) for hip pain, Non-Arthritic Hip Score (NAHS) for function, and vocational assessments including functional activity assessment (FAA) and Joint Medical Employment Standard for military employability and deployability. Results 101 patients completed the study (mean age=33 years) (male:female:75:26) (Royal Navy/British Army/Royal Air Force: 13%/48%/39%). Outcomes demonstrated significant improvements with large effect size. Preoperative NAHS mean=62.9 (SD 16.4), 12-month postoperative NAHS mean=78.8 (18.3), mean improvement in NAHS=15.9 (95% CI 12.3 to 19.5, p<0.001). Preoperative VAS pain mean=51.3 (20.9), 12-month postoperative VAS pain=25.6 (24.5). Mean improvement 25.7 (95% CI 19.4 to 31.99, p<0.001). 73% of patients had a deployable medical category at 12 months postoperative. Conclusions These data confirm that hip arthroscopy as part of a structured evidence-based multidisciplinary care pathway produces significant and continued symptomatic, functional and vocational improvements over a 12-month period in a military population exposed to high intensity, weight-bearing exercise in uncontrolled and unforgiving environments.
Similarity of deep continental cumulus convection as revealed by a three-dimensional cloud-resolving model

A three-dimensional cloud-resolving simulation of midlatitude continental convection during the Atmospheric Radiation Measurement (ARM) program summer 1997 intensive observation period (IOP) is used to study the similarity of several second and third statistical moments, and second-moment budgets among five episodes of deep convection. Several parameter scales relevant to deep convection similarity are introduced. The dimensionless vertical profiles of the vertical velocity variance and its third moment, cumulus kinetic energy, the prognostic variables’ variances and fluxes, their budgets, as well as several triple correlations cluster together, confirming the dynamical similarity of the simulated convective events. The dimensionless budgets of several second-order moments, such as convective kinetic energy (CKE), its vertical and horizontal components, variance, and vertical fluxes of the prognostic thermodynamic variables, as well as the momentum flux, are also presented. The most interesting aspect of the simulated CKE budget is that, in contrast to the boundary layer and shallow trade wind cumulus convection, the dissipation term is relatively small compared to the dominant buoyancy production, transport, and pressure correlation terms. The prognostic equation for the bulk CKE, defined as the vertically integrated mean CKE per unit area, is also discussed. It is found that the so-called bulk CKE dissipation timescale ranges in the simulation from 4 to 8 h. Therefore, the bulk CKE, mostly contained in the horizontal branches of mesoscale circulations associated with the deep convective systems, can persist much longer than the lifetime of an individual convective cloud. It is also found that the fraction of the bulk CKE associated with the vertical motions is about the same for all of the events considered, suggesting a strong correlation between the bulk CKE and the strength of the convective updrafts. It is shown that the bulk CKE dissipation timescale is inversely proportional to the square root of the bulk CKE itself. It is also found that the convective velocity scale is closely related to the convective available potential energy (CAPE) of the thermodynamic sounding taken immediately before a particular convective event.