Miracle-dz/UniFAR-FTUs huggingface dataset:
Shoot-foliage relationships in deciduous, semideciduous, and evergreen cerrado tree species

The morphology and the biomass allocation in shoots and leaves were investigated in 15 cerrado tree species with distinct leaf phenology growing under natural conditions. Higher values of leaf/shoot ratio on mass base, individual leaf area, leaf area per shoot, leaf display index, and leaf number per shoot length were found in deciduous than in evergreen species. The differences about shoot-foliage relationship across leaf phenological groups could be explained by plagiotropic shoots on deciduous and by erect shoots in semideciduous and evergreen species. Plagiotropic shoots allow similar irradiance along shoots and high biomass allocation in favor of leaves without foliage self-shading in deciduous tree species. The structural differentiation between short and long shoots was indicated by an exponential relationship between leaf display index and shoot length in all deciduous, in three semideciduous, and in two evergreen species. Therefore, especially in deciduous, the short shoots had higher leaf area per unit of length than the long shoots. The differentiation between short and long shoots depends on the shoot length in deciduous because of the leaf number on shoot is predetermined in buds. Contrastingly, the leaf neo-formation in semideciduous and in evergreen tree species keeps the shoot-leaf relationship per shoot length more constant, because of the foliage being produced according to the shoot growth during the year. In conclusion, the foliage persistence, the shoot inclination, the type of leaf production and the resources allocation between autotrophic and heterotrophic vegetative canopy parts are interdependent in cerrado tree species across different leaf phenological groups.
Influence of defatted maize germ flour addition in wheat: maize bread formulations

Wheat bread is considered to be nutritionally poor and the supplementation of wheat flour with other flours is a powerful tool to improve the nutritional quality. Maize flour contains high levels of many important vitamins and minerals. On the other hand, defatted maize germ, a by-product of the corn oil industry, is rich in protein, dietary fiber and minerals. Addition of maize flour to wheat flour at levels of 30%, 40%, 50% and defatted maize germ flour to wheat: maize blends at levels of 5%,10%,15% was carried out to examine the effects on the baking and sensory characteristics of bread. The results of this study suggest that the incorporation of the maize flour at level up to 40% and defatted maize germ flour at level up to 15% produces bread without any negative effects in quality attributes and reasonable acceptance offering promising a nutritious and healthy alternative to consumers.
Analysis of the Heat-Shield Experiment on the Pioneer-Venus Entry Probes

Information obtained during work on the experiment includes flight dat.a on heat-shield performance, data from ground-based tests in support of the experiment, and comparison of analytical and experimental results. The flight results were obtained from instrumentation on the heat shields of the four Pioneer-Venus entry probes which entered the atmosphere of Venus on December 9, 1978. The gr-ound-based tests include experiments in plasma-jet facilities, measurement of the thermal properties of the heat-shield material, and determination of the decomposition kinetics and composition of the heat-shield material. The analysis includes comparisons of experimental results and computations of the material performance based on a theoretical model i ng .
Advertising and Portfolio Choice

This paper examines the role that advertising plays in the mutual fund industry and whether advertising affects investors’ fund and portfolio choices. Content analysis shows that only a small fraction of fund advertising is directly informative about characteristics relevant for rational investors, such as fund fees. Higher quantities of advertising do not signal ex ante higher unobservable fund manager ability, because funds that advertise more are not associated with higher post-advertising excess returns. Fund advertising is shown to affect investors’ choices, although it provides little information. These results do not seem to be driven by the endogeneity of advertising, and are robust to a series of robustness checks. Finally, advertising is found to steer people towards portfolios with higher fees and more risk, through higher exposure to equities, more active management, more “hot” sectors, and more home bias. This evidence has implications for welfare analysis, asset pricing and public policy, and may serve as a starting point for broader analysis of marketing and persuasion efforts in financial markets. JEL classification: G11; G18; G23; M31; M37
Effect of one time high dose “stoss therapy” of vitamin D on glucose homeostasis in high risk obese adolescents

ABSTRACT Objective To study the effect of using a one time high dose “stoss therapy” of vitamin D2 (ergocalciferol: VD2) on indices of insulin sensitivity {whole body sensitivity index: WBISI} and secretion {insulinogenic index: IGI} measured during an oral glucose tolerance test (OGTT) in obese adolescents with VDD (25 OHD; serum metabolite of vit D: < 30 ng/dL). Subjects and methods In a randomized placebo controlled cross over design 20 obese adolescents with vitamin D deficiency (VDD) had baseline OGTT. Arm A received one time high dose 300,000 IU of ergocalciferol and Arm B received placebo. After 6 weeks the adolescents were reassigned to Arm A if they were in Arm B and vice versa. 25OHD, calcium, parathyroid hormone, comprehensive metabolic panel, urine calcium creatinine ratio were measured at each study visit. OGTTs to assess indices of sensitivity and secretion were done at baseline, 6 weeks and 12 weeks respectively. Results Adolescents were obese and insulin resistant (mean ± SD: mean age = 15.1 ± 1.9 years; BMI: 32.7 ± 9.8; homeostatic model of insulin resistance: HOMA-IR: 4.2 ± 2.8). Stoss therapy with VD2 increased 25OHD from baseline (16.7 ± 2.9 to 19.5 ± 4.5; p = 0.0029) when compared to the placebo. WBISI (2.8 ± 1.9) showed a trend towards improvement in Rx group (p = 0.0577) after adjustment for covariates. IGI (3 ± 2.2) showed an improvement in both Rx and placebo groups. Conclusions Our study demonstrated that using a high dose of VD2 (300,000 IU) did not have any beneficial effect on insulin sensitivity (whole body sensitivity index {WBISI}) and secretory indices (insulinogenic index {IGI}) in obese adolescents. High dose “stoss therapy” of VD2 did not appear to have any beneficial effect on glucose homeostasis on obese adolescents.
The Role of Preview Validity in Predictability and Frequency Effects on Eye Movements in Reading

A word’s predictability, as measured by its cloze probability, has a robust influence on the time a reader’s eyes spend on the word, with more predictable words receiving shorter fixations. However, several previous studies using the boundary paradigm have found no apparent effect of predictability on early reading time measures when the reader does not have valid parafoveal preview of the target word. The present study directly assesses this pattern in two experiments, demonstrating evidence for a null effect of predictability on first fixation and gaze duration with invalid preview, supported by Bayes factor analyses. While the effect of context independent word frequency is shown to survive with invalid preview, consistent with previous studies, the effect of predictability is eliminated with both unrelated word previews and random letter string previews. These results suggest that a word’s predictability influences early stages of orthographic processing, and does so only when perceptual evidence is equivocal, as is the case when the word is initially viewed in parafoveal vision. Word frequency may influence not only early orthographic processing, but also later processing stages.
Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration

Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95–1.02) in group A, 0.98 (0.93–1.04) in group B, and 0.95 (0.89–1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07–1.23) in group A, 1.13 (1.05–1.22) in group B, and 1.12 (1.05–1.20) in group C. Conclusions We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.
Is quetiapine suitable for treatment of acute schizophrenia with catatonic stupor? A case series of 39 patients

Purpose We aimed to determine which antipsychotic is most effective for the treatment of acute schizophrenia with catatonic stupor. Patients and methods Data were obtained from the medical records of 450 patients with the diagnosis of schizophrenia, who had received acute psychiatric inpatient treatment between January 2008 and December 2010 at our hospital. Among them, 39 patients (8.7%) met the definition of catatonic stupor during hospitalization. The diagnoses of schizophrenia in all 39 patients were reconfirmed during the maintenance phase. We retrospectively reviewed the medical records of these 39 patients to investigate which antipsychotics were chosen for treatment during the period from admission to recovery from catatonia, at the time of discharge, and 12 and 30 months after discharge. Results As compared to other antipsychotics, it was found out that use of quetiapine had better outcomes and hence was used more often. A total of 61.5% of patients were on quetiapine at the time of recovery from catatonia and 51.3% of patients were on quetiapine at the time of discharge as compared to only 17.9% of patients on quetiapine on admission. However, at 12 and 30 months after discharge, the rates had decreased to 38.4% and 25.6%. Similarly, of 29 patients who were not administered electroconvulsive therapy, quetiapine was used at significantly higher rates at the time of recovery from catatonia (48.3%) than at the time of admission (17.2%). All 39 patients had received an antipsychotic as the first-line treatment and some antipsychotics might have contributed to the development of catatonia. Conclusion This study suggests that quetiapine is a promising agent for the treatment of schizophrenia with catatonic stupor during the acute phase.
Bayesian Estimation of an Open Economy DSGE Model with Incomplete Pass-Through

In this paper we develop a dynamic stochastic general equilibrium (DSGE) model for an open economy, and estimate it on Euro area data using Bayesian estimation techniques. The model incorporates several open economy features, as well as a number of nominal and real frictions that have proven to be important for the empirical fit of closed economy models. The paper offers: i) a theoretical development of the standard DSGE model into an open economy setting, ii) Bayesian estimation of the model, including assesments of the relative importance of various shocks and frictions for explaining the dynamic development of an open economy, and iii) an evaluation of the model's empirical properties using standard validation methods.
Turbo-MIMO for wireless communications

This article reviews an important class of MIMO wireless communications, known collectively as turbo-MIMO systems. A distinctive property of turbo-MIMO wireless communication systems is that they can attain a channel capacity close to the Shannon limit and do so in a computationally manageable manner. The article focuses attention on a subclass of turbo-MIMO systems that use space-time coding based on bit-inter-leaved coded modulation. Different computationally manageable decoding (detection) strategies are briefly discussed. The article also includes computer experiments that are intended to improve the understanding of specific issues involved in the design of turbo-MIMO systems.
Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages

The pathogenic fungus Cryptococcus enters the human host via inhalation into the lung and is able to reside in a niche environment that is serum- (opsonin) limiting. Little is known about the mechanism by which nonopsonic phagocytosis occurs via phagocytes in such situations. Using a combination of soluble inhibitors of phagocytic receptors and macrophages derived from knockout mice and human volunteers, we show that uptake of nonopsonized Cryptococcus neoformans and C. gattii via the mannose receptor is dependent on macrophage activation by cytokines. However, although uptake of C. neoformans is via both dectin-1 and dectin-2, C. gattii uptake occurs largely via dectin-1. Interestingly, dectin inhibitors also blocked phagocytosis of unopsonized Cryptococci in wax moth (Galleria mellonella) larvae and partially protected the larvae from infection by both fungi, supporting a key role for host phagocytes in augmenting early disease establishment. Finally, we demonstrated that internalization of nonopsonized Cryptococci is not accompanied by the nuclear translocation of NF-κB or its concomitant production of proinflammatory cytokines such as TNF-α. Thus, nonopsonized Cryptococci are recognized by mammalian phagocytes in a manner that minimizes proinflammatory cytokine production and potentially facilitates fungal pathogenesis.
RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling

Background: Mutations in RBM20 (RNA-binding motif protein 20) cause a clinically aggressive form of dilated cardiomyopathy, with an increased risk of malignant ventricular arrhythmias. RBM20 is a splicing factor that targets multiple pivotal cardiac genes, such as Titin (TTN) and CAMK2D (calcium/calmodulin-dependent kinase II delta). Aberrant TTN splicing is thought to be the main determinant of RBM20-induced dilated cardiomyopathy, but is not likely to explain the increased risk of arrhythmias. Here, we investigated the extent to which RBM20 mutation carriers have an increased risk of arrhythmias and explore the underlying molecular mechanism. Methods: We compared clinical characteristics of RBM20 and TTN mutation carriers and used our previously generated Rbm20 knockout (KO) mice to investigate downstream effects of Rbm20-dependent splicing. Cellular electrophysiology and Ca2+ measurements were performed on isolated cardiomyocytes from Rbm20 KO mice to determine the intracellular consequences of reduced Rbm20 levels. Results: Sustained ventricular arrhythmias were more frequent in human RBM20 mutation carriers than in TTN mutation carriers (44% versus 5%, respectively, P=0.006). Splicing events that affected Ca2+- and ion-handling genes were enriched in Rbm20 KO mice, most notably in the genes CamkII&dgr; and RyR2. Aberrant splicing of CamkII&dgr; in Rbm20 KO mice resulted in a remarkable shift of CamkII&dgr; toward the &dgr;-A isoform that is known to activate the L-type Ca2+ current (ICa,L). In line with this, we found an increased ICa,L, intracellular Ca2+ overload and increased sarcoplasmic reticulum Ca2+ content in Rbm20 KO myocytes. In addition, not only complete loss of Rbm20, but also heterozygous loss of Rbm20 increased spontaneous sarcoplasmic reticulum Ca2+ releases, which could be attenuated by treatment with the ICa,L antagonist verapamil. Conclusions: We show that loss of Rbm20 disturbs Ca2+ handling and leads to more proarrhythmic Ca2+ releases from the sarcoplasmic reticulum. Patients that carry a pathogenic RBM20 mutation have more ventricular arrhythmias despite a similar left ventricular function, in comparison with patients with a TTN mutation. Our experimental data suggest that RBM20 mutation carriers may benefit from treatment with an ICa,L blocker to reduce their arrhythmia burden.
Polarized object detection in crabs: a two-channel system

ABSTRACT Many animal species take advantage of polarization vision for vital tasks such as orientation, communication and contrast enhancement. Previous studies have suggested that decapod crustaceans use a two-channel polarization system for contrast enhancement. Here, we characterize the polarization contrast sensitivity in a grapsid crab. We estimated the polarization contrast sensitivity of the animals by quantifying both their escape response and changes in heart rate when presented with polarized motion stimuli. The motion stimulus consisted of an expanding disk with an 82 deg polarization difference between the object and the background. More than 90% of animals responded by freezing or trying to avoid the polarized stimulus. In addition, we co-rotated the electric vector (e-vector) orientation of the light from the object and background by increments of 30 deg and found that the animals' escape response varied periodically with a 90 deg period. Maximum escape responses were obtained for object and background e-vectors near the vertical and horizontal orientations. Changes in cardiac response showed parallel results but also a minimum response when e-vectors of object and background were shifted by 45 deg with respect to the maxima. These results are consistent with an orthogonal receptor arrangement for the detection of polarized light, in which two channels are aligned with the vertical and horizontal orientations. It has been hypothesized that animals with object-based polarization vision rely on a two-channel detection system analogous to that of color processing in dichromats. Our results, obtained by systematically varying the e-vectors of object and background, provide strong empirical support for this theoretical model of polarized object detection. Summary: In line with theoretical models, experimental evidence indicates that a semi-terrestrial crab uses a two-channel polarization system to achieve object-based polarization vision, maximizing sensitivity in its natural environment.
Neural substrates of social facilitation effects on incentive-based performance

Abstract Throughout our lives we must perform tasks while being observed by others. Previous studies have shown that the presence of an audience can cause increases in an individual’s performance as compared to when they are not being observed—a phenomenon called ‘social facilitation’. However, the neural mechanisms underlying this effect, in the context of skilled-task performance for monetary incentives, are not well understood. We used functional magnetic resonance imaging to monitor brain activity while healthy human participants performed a skilled-task during conditions in which they were paid based on their performance and observed and not observed by an audience. We found that during social facilitation, social signals represented in the dorsomedial prefrontal cortex (dmPFC) enhanced reward value computations in ventromedial prefrontal cortex (vmPFC). We also found that functional connectivity between dmPFC and ventral striatum was enhanced when participants exhibited social facilitation effects, indicative of a means by which social signals serve to modulate brain regions involved in regulating behavioral motivation. These findings illustrate how neural processing of social judgments gives rise to the enhanced motivational state that results in social facilitation of incentive-based performance.
Incorporation of the Effects of Temperature and Unloading into the Strain Rate Dependent Analysis of Polymer Matrix Materials Utilizing a State Variable Approach

A previously developed analytical formulation has been modified in order to accurately model the nonlinear, strain rate dependent deformation of polymeric materials, including the effects of hydrostatic stresses. State variable constitutive equations originally developed for metals have been modified in order to model the nonlinear, strain rate dependent deformation of polymeric materials. To account for the effects of hydrostatic stresses, which are significant in polymers, the classical J2 plasticity theory definitions of effective stress and effective inelastic strain are appropriately modified. To account for the effects of temperature on the nonlinear, strain rate dependent deformation of polymers, the isothermal equations were still applied, but some of the material constants were allowed to vary with temperature. Preliminary efforts to model the nonlinear unloading observed in polymers indicated that the methods used to compute the value of a state variable which controls the inelastic flow must be modified to account for the nonlinear unloading. To verify the developed formulation, the room temperature shear and tensile deformation response of a representative polymer has been computed across a wide range of strain rates. The high strain rate (several hundred per second) torsion response, and the low strain rate (quasi-static) tensile and torsion response of the polymer has also been simulated. In all cases, the results computed using the developed constitutive equations correlate well with experimental data. Techniques which can be used to incorporate the model into the analysis of the strain rate dependent deformation of polymer matrix composites, through the use of micromechanics techniques, are also described.
Changing trends in maxillofacial trauma: A 15 years retrospective study in the Southern Part of Haryana, India

Objective: The aim is to analyze the pattern of maxillofacial injuries and treatment outcomes in the past 15 years (2002–2016). Materials and Methods: One thousand eight hundred and fifty patients from two tertiary referral center hospitals were studied retrospectively in which the age, sex, etiology, site of fracture, and treatment modality was recorded. Results: One thousand two hundred and twenty-eight males and 622 females were operated between 2002 and 2016. Mean age was 29 ± 17.2 years. Maximum incidence was seen in the age group of 16–30 years in males, whereas in females, the predominance of trauma was seen in both 16–30 and 31–45 age groups. Road traffic accidents were responsible for the majority of fractures (42.2%), followed by assaults (26.4), sports injuries (17.6%), and fall (10.7%). Maximum fractures were of the mandible (53.5%) followed by midface (25.6%) and panfacial trauma (20.8%). Nearly 53.6% of patients underwent open reduction, and internal fixation (ORIF), 34.2% managed by the closed method and 12.1% were kept under observation. Conclusion: This study verified a young male predominance, a shift toward more assault related fractures, especially in females. Mandibular fractures were the most common of all. Moreover, the changing trend toward ORIF in the past 15 years.