Miracle-dz/UniFAR-FTUs huggingface dataset:
Wearable Devices in Medical Internet of Things: Scientific Research and Commercially Available Devices

Objectives Wearable devices are currently at the heart of just about every discussion related to the Internet of Things. The requirement for self-health monitoring and preventive medicine is increasing due to the projected dramatic increase in the number of elderly people until 2020. Developed technologies are truly able to reduce the overall costs for prevention and monitoring. This is possible by constantly monitoring health indicators in various areas, and in particular, wearable devices are considered to carry this task out. These wearable devices and mobile apps now have been integrated with telemedicine and telehealth efficiently, to structure the medical Internet of Things. This paper reviews wearable health care devices both in scientific papers and commercial efforts. Methods MIoT is demonstrated through a defined architecture design, including hardware and software dealing with wearable devices, sensors, smart phones, medical application, and medical station analyzers for further diagnosis and data storage. Results Wearables, with the help of improved technology have been developed greatly and are considered reliable tools for long-term health monitoring systems. These are applied in the observation of a large variety of health monitoring indicators in the environment, vital signs, and fitness. Conclusions Wearable devices are now used for a wide range of healthcare observation. One of the most important elements essential in data collection is the sensor. During recent years with improvement in semiconductor technology, sensors have made investigation of a full range of parameters closer to realization.
ON CERTAIN SUBCLASSES OF UNIVALENT FUNCTIONS AND RADIUS PROPERTIES

Denote by A the class of all functions f , normalized by f(0) = f ′(0) − 1 = 0, that are analytic in the unit disk ∆ = {z ∈ C : |z| 0 in ∆. A function f ∈ A is said to belong to the class U if ∣∣∣∣f ′(z) ( z
The incidence of retinopathy 10 years after diagnosis in young adult people with diabetes: results from the nationwide population-based Diabetes Incidence Study in Sweden (DISS).

OBJECTIVE To estimate the prevalence and severity of diabetic retinopathy (DR) 10 years after diagnosis in a nationwide population-based cohort study of young adult diabetic patients in Sweden. RESEARCH DESIGN AND METHODS The Diabetes Incidence Study in Sweden (DISS) aims to register all incident cases of diabetes aged 15-34 years in Sweden. In 1987-1988, 806 cases were reported, and 627 (78%) of them were followed up with regard to retinopathy 8-10 years later. The assessment was based on retinal photographs in most cases (86%). RESULTS Ten years after diagnosis, retinopathy was found in 247 patients (39%). The retinopathy was mild in 206 (33%), whereas 30 (4.8%) patients had moderate nonproliferative DR (NPDR) and 11 (1.8%) had proliferative DR (PDR). Patients with retinopathy had worse glycemic control during the years than patients without (HbA(1c) 8.1 +/- 1.5% and 6.8 +/- 1.2%, respectively; P < 0.001). In a Cox regression analysis, time to retinopathy was related to high HbA(1c) (P < 0.001) and high BMI (P = 0.001). Patients with type 2 diabetes had an increased prevalence of severe retinopathy (NPDR or PDR) compared with those with type 1 diabetes (14 of 93 [15%] versus no or mild 24 of 471 [5%], respectively; P < 0.001). CONCLUSIONS Despite modern diabetes management, 39% of young adult diabetic patients developed retinopathy within the first 10 years of the disease. Nevertheless, compared with the prevalence of retinopathy (63%), after a similar duration of diabetes before the Diabetes Control and Complications Trial, this prevalence was clearly lower. Current treatment aimed to achieve strict glycemic control has reduced the risk for developing retinopathy.
Mirrored Prominent Deck B Phenomenon: Frequent Small Losses Override Infrequent Large Gains in the Inverted Iowa Gambling Task

Since Bechara et al. pioneered its development, the Iowa Gambling Task (IGT) has been widely applied to elucidate decision behavior and medial prefrontal function. Although most decision makers can hunch the final benefits of IGT, ventromedial prefrontal lesions generate a myopic choice pattern. Additionally, the Iowa group developed a revised IGT (inverted IGT, iIGT) to confirm the IGT validity. Each iIGT trial was generated from the trial of IGT by multiplying by a “−” to create an inverted monetary value. Thus, bad decks A and B in the IGT become good decks iA and iB in the iIGT; additionally, good decks C and D in the IGT become bad decks iC and iD in the iIGT. Furthermore, IGT possessed mostly the gain trials, and iIGT possessed mainly the loss trials. Therefore, IGT is a frequent-gain–based task, and iIGT is a frequent-loss–based task. However, a growing number of IGT-related studies have identified confounding factors in IGT (i.e., gain-loss frequency), which are demonstrated by the prominent deck B phenomenon (PDB phenomenon). Nevertheless, the mirrored PDB phenomenon and guiding power of gain-loss frequency in iIGT have seldom been reexamined. This experimental finding supports the prediction based on gain-loss frequency. This study identifies the mirrored PDB phenomenon. Frequent small losses override occasional large gains in deck iB of the iIGT. Learning curve analysis generally supports the phenomenon based on gain-loss frequency rather than final outcome. In terms of iIGT and simple versions of iIGT, results of this study demonstrate that high-frequency loss, rather than a satisfactory final outcome, dominates the preference of normal decision makers under uncertainty. Furthermore, normal subjects prefer “no immediate punishment” rather than “final reward” under uncertainty.
Effects of the 26-weeks Obesity Management Program on Obesity Index, Self-esteem, Self-efficacy, and Body Image among Obese Elementary School Children

This study was conducted to develop a 26-week obesity management program and examine the effects of this program on obesity index (body mass index, fat mass percentage, and triglyceride) and psychological variables, self-esteem, dietary self-efficacy, physical activity self-efficacy, and body image among 46 4th-6th obese elementary school children with a BMI above 20 kg/m2 using a nonequivalent control group quasi-experimental design (experimental group=23, control group=23). This program included a 12-week intensive course (12 times for group education on obesity, exercise, and nutrition, 36 times for practicing diet and physical exercise, and 5 times for psychological counseling) and a 14-week follow-up course (3 times for group education, 3 times for checking diet and physical exercise, and 1 time for psychological counseling. The collected data were analyzed by the Kolmogorov-Smirnov test, chi-squared test, Fisher's exact probability, t-test, and ANCOVA. There were above normal values in body mass index (20 kg/m2), fat mass percentage (15-20%), and triglyceride tolerance (90 mg/dl) in experimental group and control group. The body mass index (F=94.869, p<.001), fat mass percentage (F=37.361, p<.001), and triglyceride tolerance (F=7.907, p= .007) were significantly lower, while self-esteem (F=19.661, p<.001), dietary self-efficacy (F=16.942, p<.001), physical activity self-efficacy (F=9.363, p= .004), and body image (F=9.782, p= .003) were significantly higher in the experimental group than the control group after 26 weeks. This study provides evidence that the 26-weeks obesity management program is an effective nursing intervention for managing obesity and psychological variables of obese elementary school children.
Altered Structural Correlates of Impulsivity in Adolescents with Internet Gaming Disorder

Recent studies suggested that internet gaming disorder (IGD) was associated with impulsivity and structural abnormalities in brain gray matter (GM). However, no morphometric study has examined the association between GM and impulsivity in IGD individuals. In this study, 25 adolescents with IGD and 27 healthy controls (HCs) were recruited, and the relationship between Barratt impulsiveness scale-11 (BIS) score and gray matter volume (GMV) was investigated with the voxel-based morphometric (VBM) correlation analysis. Then, the intergroup differences in correlation between BIS score and GMV were tested across all GM voxels. Our results showed that the correlations between BIS score and GMV of the right dorsomedial prefrontal cortex (dmPFC), the bilateral insula and the orbitofrontal cortex (OFC), the right amygdala and the left fusiform gyrus decreased in the IGD group compared to the HCs. Region-of-interest (ROI) analysis revealed that GMV in all these clusters showed significant positive correlations with BIS score in the HCs, while no significant correlation was found in the IGD group. Our findings demonstrated that dysfunction of these brain areas involved in the behavior inhibition, attention and emotion regulation might contribute to impulse control problems in IGD adolescents.
ICE NUCLEATION C THEORY A TUTORIAL FOR PRESENTATION AT THE NCAR / ASP 1999 SUMMER COLLOQUIUM

The homogeneous and heterogeneous nucleation of ice are described in terms of the ’classical’ thermodynamic/kinetic theory, and in terms of various qualitative notions suggested by empirical results. The aim of this presentation is to provide a general, intuitive and critical appreciation of the issues involved. It is not meant to be exhaustive or definitive. Focus is on ice nucleation in the atmosphere.
Local Reorientation Dynamics of Semiflexible Polymers in the Melt

The reorientation dynamics of local tangent vectors of chains in isotropic amorphous melts containing semiflexible model polymers was studied by molecular dynamics simulations. The reorientation is strongly influenced both by the local chain stiffness and by the overall chain length. It takes place by two different subsequent processes: a short-time nonexponential decay and a long-time exponential reorientation arising from the relaxation of medium-size chain segments. Both processes depend on stiffness and chain length. The strong influence of the chain length on the chain dynamics is in marked contrast to its negligible effect on the static structure of the melt. The local structure shows only a small dependence on the stiffness and is independent of chain length. Calculated correlation functions related to double-quantum NMR experiments are in qualitative agreement with experiments on entangled melts. A plateau is observed in the dependence of segment reorientation on the mean-squared displacement of .
The Pairwise Velocity Dispersion of Galaxies: Luminosity Dependence and a New Test of Galaxy Formation Models

We present the first determination of the pairwise velocity dispersion (PVD) for galaxies in different luminosity intervals using the final release of the Two-Degree Field Galaxy Redshift Survey (2dFGRS). We have discovered quite surprisingly that the relative velocities of the faint galaxies at small separation are very high, around 700 km s-1, reaching similar values as the brightest galaxies. At intermediate luminosities M* - 1 (M* is the characteristic luminosity of the Schechter function), the relative velocities exhibit a well-defined steep minimum near 400 km s-1. This result has been derived using a novel method to determine the real-space power spectrum and the PVD from the redshift-space power spectrum of the 2dFGRS. Combined with the observed luminosity dependence of clustering, our result implies that quite a fraction of faint galaxies, as well as the brightest ones, are in massive halos of galaxy cluster size, but most of the M* galaxies are in galactic halos. Our observed result is compared with the current halo model of galaxies of Yang et al., which was obtained by matching the clustering and luminosity functions of the 2dFGRS. With the model parameters they favored most, the halo model seems to be unable to reproduce the luminosity dependence of the PVD, because it predicts a monotonically increasing PVD with the luminosity. We discuss a possible solution to this model by raising the faint-end slope of the conditional luminosity function in rich clusters. The PVD luminosity dependence may also be an important constraint in general on theories of galaxy formation, such as semianalytical models and hydro/N-body simulations of galaxy formation.
8-Oxo-7,8-dihydro-2′-deoxyguanosine and other lesions along the coding strand of the exon 5 of the tumour suppressor gene P53 in a breast cancer case-control study

The next-generation sequencing studies of breast cancer have reported that the tumour suppressor P53 (TP53) gene is mutated in more than 40% of the tumours. We studied the levels of oxidative lesions, including 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), along the coding strand of the exon 5 in breast cancer patients as well as in a reactive oxygen species (ROS)-attacked breast cancer cell line using the ligation-mediated polymerase chain reaction technique. We detected a significant ‘in vitro’ generation of 8-oxodG between the codons 163 and 175, corresponding to a TP53 region with high mutation prevalence, after treatment with xanthine plus xanthine oxidase, a ROS-generating system. Then, we evaluated the occurrence of oxidative lesions in the DNA-binding domain of the TP53 in the core needle biopsies of 113 of women undergoing breast investigation for diagnostic purpose. An increment of oxidative damage at the −G− residues into the codons 163 and 175 was found in the cancer cases as compared to the controls. We found significant associations with the pathological stage and the histological grade of tumours. As the major news of this study, this largest analysis of genomic footprinting of oxidative lesions at the TP53 sequence level to date provided a first roadmap describing the signatures of oxidative lesions in human breast cancer. Our results provide evidence that the generation of oxidative lesions at single nucleotide resolution is not an event highly stochastic, but causes a characteristic pattern of DNA lesions at the site of mutations in the TP53, suggesting causal relationship between oxidative DNA adducts and breast cancer.
Cleanroom energy benchmarking in high-tech and biotech industries

Cleanrooms, critical to a wide range of industries, universities, and government facilities, are extremely energy intensive. Consequently, energy represents a significant operating cost for these facilities. Improving energy efficiency in cleanrooms will yield dramatic productivity improvement. But more importantly to the industries which rely on cleanrooms, base load reduction will also improve reliability. The number of cleanrooms in the US is growing and the cleanroom environmental systems' energy use is increasing due to increases in total square footage and trends toward more energy intensive, higher cleanliness applications. In California, many industries important to the State's economy utilize cleanrooms. In California these industries utilize over 150 cleanrooms with a total of 4.2 million sq. ft. (McIlvaine). Energy intensive high tech buildings offer an attractive incentive for large base load energy reduction. Opportunities for energy efficiency improvement exist in virtually all operating cleanrooms as well as in new designs. To understand the opportunities and their potential impact, Pacific Gas and Electric Company sponsored a project to benchmark energy use in cleanrooms in the electronics (high-tech) and biotechnology industries. Both of these industries are heavily dependent intensive cleanroom environments for research and manufacturing. In California these two industries account for approximately 3.6 million sq. ft. of cleanroom (McIlvaine, 1996) and 4349 GWh/yr. (Sartor et al. 1999). Little comparative energy information on cleanroom environmental systems was previously available. Benchmarking energy use allows direct comparisons leading to identification of best practices, efficiency innovations, and highlighting previously masked design or operational problems.
Pengaruh Sistem Pengendalian Internal Pemerintah Dan Komitmen Organisasi Terhadap Kualitas Laporan Keuangan Daerah

Penelitian ini bertujuan untuk mengetahui pengaruh sistem pengendalian internal pemerintah dan komitmen organisasi terhadap kualitas laporan keuangan pemerintah daerah pada DPPKAD, SETDA dan KOMINFO Kota Sukabumi. Teknik penentuan sampel menggunakan teknik Purposive Sampling dengan jumlah responden sebanyak 40 orang. Jenis data yang digunakan adalah data primer. Metode pengumpulan data dilakukann dengan kuesioner. Teknik analisis menggunakan program SPSS versi 23.0 Hasil penelitian ini menunjukan bahwa, 1) Sistem Pengendalian Internal Pemerintah berpengaruh positif dan signifikan terhadap kualitas laporan keuangan, 2) Komitmen Organisasi berpangaruh positif dan signifikan terhadap kualitas laporan keuangan, 3) Sistem Pengendalian Internal dan Komitmen Organisasi berpengaruh positif dan signifikan terhadap kualitas laporan keuangan pemerintah daerah. Koefisien determinasi menunjukkan pengaruh sistem pengendalian intern dan komitmen organisasi terhadap kualitas laporan keuangan pemerintah daerah adalah sebesar 35% dan sisanya 65% dipengaruhi faktor lain.
On the interaction between affective and cognitive processes in decisions under risk: Underlying behavioral, neural, and neuroendocrine correlates

The present thesis taps into the field of neuropsychological decision-making research. In this field it is common to distinguish between decisions under ambiguity and decisions under risk. In situations under ambiguity the decision maker has no information about the consequences and their probabilities of occurrence, which is why she/he has to rely on her/his intuitions and experiences with the situation (e.g., Bechara, Damasio, Damasio, & Anderson, 1994). In contrast, in situations under risk information about consequences and probabilities is given and the decider can process them to make a decision (e.g., Brand, Labudda, & Markowitsch, 2006). In their model of decision making under risk, Brand and colleagues (2006) postulated the involvement of cognitive and affective processes. Over the years, several studies supported this assumption. However, little was known about the interaction between the underlying cognitive and affective processes and the associated neural correlates. The research for this thesis was conducted to fill this gap. The first study aimed to investigate the neural correlates of the interaction between decision making, additional cognitive demand, and stress. It was found that stress appears to trigger a shift from serial to parallel processing brain regions to prevent decision-making performance from decreasing, supporting the assumptions made in previous studies (Pabst, Schoofs, Pawlikowski, Brand, & Wolf, 2013; Plessow, Schade, Kirschbaum, & Fischer, 2012). The second study concentrated on the possibility that cognitive functions might have an important role in facilitating decision making in situations when both processing routes (affective and cognitive) are demanded at the same time. The results revealed that although affective stimuli (especially those of positive valence) interfere with the decision-making performance, participants with superior executive functioning seem to be unaffected and were still able to decide advantageously. In contrast, participants with inferior executive functions were affected and showed disadvantageous decision making. In the third study the focus of investigation was which subcomponents of executive functioning might be involved in decision-making situations with additional cognitive demand. The findings suggest the involvement of higher-level executive functions and lower-level executive functions in decision making when the cognitive route is additionally loaded by another cognitive demanding task simultaneously. In order to measure the additional cognitive load, a dual task consisting of a decision-making task and an additional cognitive task was used in each study. In conclusion, the findings suggest that in decision-making situations with additional cognitive and affective demand, underlying affective and cognitive processes interact in a way that they prevent a decrease of decision-making performance. The findings and the therefrom derived assumptions are discussed in detail and perspectives for future outcomes are given.
Yoga for traumatic stress: A three paper dissertation

This three paper dissertation considers whether yoga—a popular mind-body practice combining physical postures and movement, mindfulness, and breath exercises—may be a useful component of treatment for adult trauma survivors. The first paper involves a systematic review and meta-analyses of the current evidence base for yoga in the treatment of anxiety, depression, and PTSD among trauma survivors. The second and third papers are grounded in a single, mixed-methods multi-wave data source aimed at examining yoga’s contribution to recovery for adult women who have complex trauma histories (i.e., sustained and/or multiple traumatic experiences such as recurring physical or sexual abuse). The second paper is a quantitative study employing hierarchical linear and logistic regression to examine associations between yoga practice and reductions in traumatic symptomology over time. The third paper is a hermeneutic phenomenological study exploring how women with complex trauma histories experience practicing yoga and its potential role in their coping and healing processes over time. Taken together, these three papers offer insights into the complex healing needs of adult survivors suffering from the effects of traumatization, and the promising role of yoga within their recovery processes.
PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21

Pulmonary hypertension (PH) is a progressive and often fatal disorder whose pathogenesis involves pulmonary artery smooth muscle cell (PASMC) proliferation. Although modern PH therapies have significantly improved survival, continued progress rests on the discovery of novel therapies and molecular targets. MicroRNA (miR)-21 has emerged as an important non-coding RNA that contributes to PH pathogenesis by enhancing vascular cell proliferation, however little is known about available therapies that modulate its expression. We previously demonstrated that peroxisome proliferator-activated receptor gamma (PPARγ) agonists attenuated hypoxia-induced HPASMC proliferation, vascular remodeling and PH through pleiotropic actions on multiple targets, including transforming growth factor (TGF)-β1 and phosphatase and tensin homolog deleted on chromosome 10 (PTEN). PTEN is a validated target of miR-21. We therefore hypothesized that antiproliferative effects conferred by PPARγ activation are mediated through inhibition of hypoxia-induced miR-21 expression. Human PASMC monolayers were exposed to hypoxia then treated with the PPARγ agonist, rosiglitazone (RSG,10 μM), or in parallel, C57Bl/6J mice were exposed to hypoxia then treated with RSG. RSG attenuated hypoxic increases in miR-21 expression in vitro and in vivo and abrogated reductions in PTEN and PASMC proliferation. Antiproliferative effects of RSG were lost following siRNA-mediated PTEN depletion. Furthermore, miR-21 mimic decreased PTEN and stimulated PASMC proliferation, whereas miR-21 inhibition increased PTEN and attenuated hypoxia-induced HPASMC proliferation. Collectively, these results demonstrate that PPARγ ligands regulate proliferative responses to hypoxia by preventing hypoxic increases in miR-21 and reductions in PTEN. These findings further clarify molecular mechanisms that support targeting PPARγ to attenuate pathogenic derangements in PH.