Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular and Cellular Pathobiology Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target

Glioblastoma is the most common form of primary adult brain tumors. A majority of glioblastomas grow invasively into distant brain tissue, leading to tumor recurrence, which is ultimately incurable. It is, therefore, essential to discover master regulators that control glioblastoma invasiveness and target them therapeutically. We show here that the transcriptional regulator Id-1 plays a critical role in modulating the invasiveness of glioblastoma cell lines and primary glioblastoma cells. Id-1 expression levels positively correlate with glioma cell invasiveness in culture andwith histopathologic grades in patient biopsies. Id-1 knockdown dramatically reduces glioblastoma cell invasion that is accompanied by profound morphologic changes and robust reduction in expression levels of "mesenchymal" markers, as well as inhibition of self-renewal potential and downregulation of glioma stem cell markers. Importantly, genetic knockdown of Id-1 leads to a significant increase in survival in an orthotopic model of human glioblastoma. Furthermore, we show that a nontoxic compound, cannabidiol, significantly downregulates Id-1 gene expression and associated glioma cell invasiveness and self-renewal. In addition, cannabidiol significantly inhibits the invasion of glioblastoma cells through an organotypic brain slice and glioma progression in vivo. Our results suggest that Id-1 regulates multiple tumor-promoting pathways in glioblastoma and that drugs targeting Id-1 represent a novel and promising strategy for improving the therapy and outcome of patients with glioblastoma. Cancer Res; 73(5); 1559–69. 2012 AACR.
The impact of emergent virtual leadership competencies on team effectiveness

Purpose – The research on virtual team leadership does well to describe the skills that are needed to guide and direct effective teams. However, what is presupposed in the previous research is that virtual teams have assigned leaders. That is, leaders were either management, appointed by management or were chosen by the team itself. Yet in today's global economy not all virtual teams have assigned leaders, instead many virtual team leaders emerge on their own to direct the group's actions. The purpose of this paper is to examine which emergent leadership competencies most impact virtual team effectiveness. Design/methodology/approach – This is a mixed method study where both a participant survey and content analysis of actual participant messages are used to determine the competencies of emergent virtual team leaders. The research participants for the current study were required to work in assigned teams on organizational case analyses. At the end of each case, teams presented their solutions in the form .
Normalization of the psychometric hepatic encephalopathy score in Polish population. A prospective, quantified electroencephalography study

The psychometric hepatic encephalopathy score (PHES) is recommended as a gold standard in evaluation of minimal hepatic encephalopathy (HE). Normative databases have been collected in few countries, clearly showing differences among studied groups. Thus, the standardization of PHES for selected populations remains necessary.
Attitudes of children toward an unfamiliar peer using an AAC device with and without voice output

This study describes the development of the Communication Aid/Device Attitudinal Questionnaire (CADAQ), which was used to measure children's attitudes toward an unfamiliar peer using an AAC device. One hundred and fifteen children, aged 11 to 13 years, viewed a videotape of a 13-year-old boy with cerebral palsy and no functional speech as he communicated with and without voice output. Attitudes were measured according to three factors: affective/behavioral, cognitive/belief, and communicative competence. An item analysis demonstrated good internal consistency of the CADAQ. The results showed that children's attitudes were more favorable when the focus child communicated with voice output and, overall, girls' attitudes toward the focus child were more positive than boys' attitudes.
An empirical study of salesperson stereotypes amongst UK students and their implications for recruitment

The success of recruitment efforts can have a major impact on sales force effectiveness. Students have long been considered a good source of potential sales recruits, but research has found students have generally negative perceptions of selling as a career. One reason for such perceptions may be negative stereotypes of salespeople held by students. However information on the content of UK sales stereotypes remains anecdotal at best. This study empirically examines UK business students' stereotypes of salespeople using a two-stage approach. Findings suggest that these stereotypes are generally negative. However, we create profiles of salespeople using our findings, and consequently uncover some positive aspects to the stereotype. The study provides instruction on how to use stereotypes in subsequent work, as well as how to utilise the profiles in recruitment efforts.
Cognitive Tests in Early Childhood

Cognitive assessment of young children contributes to high-stakes decisions because results are often used to determine eligibility for early intervention and special education. Previous reviews of cognitive measures for young children highlighted concerns regarding adequacy of standardization samples, steep item gradients, and insufficient floors for young children functioning at lower levels. The present report extends previous reviews by including measures recently published or revised, nonverbal cognitive assessment tools, and issues specific to assessing bilingual or non-English-speaking children. Sixteen tests were reviewed, including all available measures of cognitive functioning for 2- to 4-year-old children normed in the United States. Test characteristics evaluated included (a) representativeness and recency of standardization data, (b) item bias analysis, (c) psychometric characteristics, and (d) appropriateness for assessing young children with developmental delays and non-English-speaking children. Implications are discussed for clinicians, researchers, and test developers.
Ethnography in Educational Research: The Dynamics of Diffusion

Anthropologists have a long tradition of studying the diffusion of c u l t u r a l innova t ions (Boaz, 1896/1940; Driver, 1961; Hallowell, 1948; Kroeber, 1931,1952; Morgan, 1877; Sapir, 1916/1949; Spindler, 1955; Spindler & Goldschmidt, 1952; L. Spindler, 1962; Tylor, 1879). Diffusion occurs during the interaction of two sociocultural systems as in times of war or during trade. Similarly, the recent interaction of ethnographic and quantitative research methodologies results in an inevitable diffusion of techniques, methods, and values. By viewing these two disciplines as "sociocultural systems" we gain an excellent opportunity to study the dynamics of diffusion between the two fields. Of particular interest is the diffusion of ethnographic techniques, which are among the most v is ib le t r a i t s c u r r e n t l y be ing transmitted.
The Presence of a Familiar Peer Does Not Affect Intensity or Enjoyment during Treadmill Exercise in Male Distance Runners or Non-Runners

The Presence of a Familiar Peer Does Not Affect Intensity or Enjoyment during Treadmill Exercise in Male Distance Runners or Non-Runners The purpose of this study was to experimentally test the effect of the exercising with a partner (versus alone) on the intensity, enjoyment, and ratings of perceived exertion (RPE) of self-paced treadmill exercise in competitive male runners and non-runner controls. Collegiate male distance runners (N=14, 20.2 ± 1.4 yr) and non-runner controls (N=10, 22.6 ± 2.01 yr) completed two exercise trials under differing social conditions (alone, with a peer) in a counterbalanced order. Exercise trials each consisted of 30-minutes of self-paced treadmill exercise with grade fixed at 0% and speed controlled voluntarily by the participant. During one visit participants exercised on a treadmill alone (alone condition). During the other visit participants exercised with a familiar peer on an identical treadmill adjacent to their own (peer condition). Total distance covered (km), average treadmill speed (km∙hr-1), enjoyment of the exercise (mm), heart rate (beats∙min-1), and rating of perceived exertion (RPE) were assessed in each condition. Mixed-model regression analysis showed no significant (p ≥ 0.40) main effect of social condition in either group for any of the dependent variables. These results suggest that the presence of a familiar peer does not alter exercise behavior or enjoyment during treadmill exercise.
Peak Expiratory Flow–Guided Self-Management Treatment of Asthma in Serbia

The aims of this study were to compare the efficacy of 1-year peak expiratory flow (PEF)–based self-management of asthma against conventional treatment and to analyze the long-term effectiveness of self-management. Eighty adult patients with persistent asthma (group B). After 1 year, significant improvement was noted in markers of asthma severity in group A but there were no changes in group B. After 6 years of the self-management program, asthma morbidity and emergency use of health services were reduced. These results show short-term and long-term effectiveness of a PEF-based self-management program in persistent asthma.
Acute bacterial, nonnecrotizing cellulitis in Finland: microbiological findings.

BACKGROUND Bacterial, nonnecrotizing cellulitis is a localized and often recurrent infection of the skin. The aim of this study was to identify the beta-hemolytic streptococci that cause acute nonnecrotizing cellulitis infection in Finland. METHODS A case-control study of 90 patients hospitalized for acute cellulitis and 90 control subjects was conducted during the period of April 2004-March 2005. Bacterial swab samples were obtained from skin lesions or any abrasion or fissured toe web. Blood culture samples were taken for detection of bacteremia. The patients, their household members, and control subjects were assessed for pharyngeal carrier status. beta-Hemolytic streptococci and Staphylococcus aureus were isolated and identified, and group A and G streptococcal isolates were further analyzed by T serotyping and emm and pulsed-field gel electrophoresis typing. RESULTS beta-Hemolytic streptococci were isolated from 26 (29%) of 90 patients, 2 isolates of which were blood-culture positive for group G streptococci, and 24 patients had culture-positive skin lesions. Group G Streptococcus (Streptococcus dysgalactiae subsp. equisimilis) was found most often and was isolated from 22% of patient samples of either skin lesions or blood, followed by group A Streptococcus, which was found in 7% of patients. Group G streptococci were also carried in the pharynx of 7% of patients and 13% of household members but was missing from control subjects. Several emm and pulsed-field gel electrophoresis types were present among the isolates. Six patients (7%) had recurrent infections during the study. In 2 patients, the group G streptococcal isolates recovered from skin lesions during 2 consecutive episodes had identical emm and pulsed-field gel electrophoresis types. CONCLUSIONS Group G streptococci, instead of group A streptococci, predominated in bacterial cellulitis. No clear predominance of a specific emm type was seen. The recurrent nature of cellulitis became evident during this study.
Molecular mechanisms of segmental patterning in the vertebrate hindbrain and neural crest

Recent work has shown that segmentation underlies the patterning of the vertebrate hindbrain and its neural crest derivatives. Several genes have been identified with segment‐restricted expression, and evidence is now emerging regarding their function and regulatory relationships. The expression patterns of Hox genes and the phenotype of null mutants indicate roles in specifying segment identity. A zinc finger gene Krox‐20 is a segment‐specific regulator of Hox expression, and it seems probable that retinoic acid receptors also regulate Hox genes in the hindbrain. The receptor tyrosine kinase gene Sek may mediate cell‐cell interactions that lead to segmentation. These studies provide a starting point for understanding the molecular basis of segmental patterning in the hindbrain.
Women's Musical Lives: Self-Managing a Freelance Career

Abstract While opportunities for women have certainly improved and they are far better represented today in a range of music sectors, Creative and Cultural Skills (2010) found that women occupy only 32.2% of all music industry related jobs, they earn less, give up their careers sooner and experience more barriers to progression than their male counterparts. It has been shown that while ‘creative labour’ can be rewarding and fulfilling it is also a source of (self-) exploitation, is insecure, involves long hours, entails working for low or no pay, through the gifting of free labour, requires high levels of commitment from a normatively younger worker and results in bulimic patterns of work. It appears that the contested nature of creative work may have particular implications for female freelance musicians but, hitherto, very little critical attention has been paid to their experiences. Using an innovative methodological approach combining visual social research methods and digital ethnography, this paper presents the findings of an exploratory study into the working lives of five professional female musicians based in London and the South West of England. It examines the nature of their work and seeks to understand how freelance careers are experienced, supported and developed. The findings suggest that this is often contingent on the context of the work, its purpose, the types of work the musicians undertake and the meanings they attribute to their various musical activities.
The dispossession of the Innu and the colonial magic of Canadian Liberalism

This article examines the legal and philosophical grounds which are used by the nation state of Canada to dispossess aboriginal people who have not ceded land through treaties. Using the Innu people of the Labrador‐Quebec peninsula as an example, my thesis is that, far from being a neutral doctrine of rights and citizenship, liberalism functions as a magical, yet ethnocidal, instrument of colonial domination and land usurpation. I demonstrate this by looking at the way in which policies such as Comprehensive Land Claims and Environmental Impact Assessment, ostensibly for the protection of the Innu and other aboriginal peoples, predetermine that land will be legally ceded and ways of life based on it exterminated. The roots of this approach are traced through an examination of the imposition of sovereignty in colonial policy and its continued assertion in Canadian court cases, including the recent Delgamuukw decision. In conclusion, I draw attention to the affinities between the ideas of contemporary liber.
Disciplinary Differences in Academic Web Presence – A Statistical Study of the UK

The Web has become an important tool for scholars to publicise their activities and disseminate their findings. In the information age, those who do not use it risk being bypassed. In this paper we introduce a statistical technique to assess the extent to which the broad spectrum of research areas are visible online in UK universities. Five broad subject categories are used for research, and inlink counts are used as indicators of online visibility or impact. The approach is designed to give more complete subject coverage than previous studies and to avoid the conceptual difficulties of a page classification approach, although one is used for triangulation. The results suggest that Science and Engineering dominate university Web presences, but with Humanities and Arts also achieving a high presence relative to its size, showing that high Web impact does not have to be restricted to the sciences. Research funding bodies should now consider whether action needs to be taken to ensure that opportunities are not being missed in the lower Web impact areas.
A Normative Approach to Shaping College Students' Attitudes Toward Organ Donation

This study tested the effects of normative influence on increasing college students' attitudes, intentions, and willingness to communicate about organ and tissue donation (OTD). It was hypothesized that students would look to their peers (referent group) in forming their own attitudes about organ donation. Three hundred thirty-nine (N = 339) participants were randomly assigned to one of five experimental conditions: (1) control group; (2) general referent/normative message group; (3) specific referent/normative message group; (4) general referent/counternormative message group; and (5) specific referent/counternormative message group. An interaction effect was predicted between message type (normative > counternormative) and attributed message source (specific referent > general referent). Students reported highly favorable attitudes toward OTD, moderate-to-high levels of intentions to become organ donors and willingness to communicate about OTD. The hypothesis that participants within the normative message condition would report more favorable attitudes, intentions, and willingness to communicate about OTD compared to participants within the counternormative message condition was supported for participants' willingness to communicate about OTD. The second hypothesis that participants within the specific referent condition would express more favorable attitudes, intentions, and willingness to communicate was rejected.
Human Emotion Recognition Based on Galvanic Skin Response Signal Feature Selection and SVM

A novel human emotion recognition method based on automatically selected Galvanic Skin Response (GSR) signal features and SVM is proposed in this paper. GSR signals were acquired by e-Health Sensor Platform V2.0. Then, the data is de-noised by wavelet function and normalized to get rid of the individual difference. 30 features are extracted from the normalized data, however, directly using of these features will lead to a low recognition rate. In order to gain the optimized features, a covariance based feature selection is employed in our method. Finally, a SVM with input of the optimized features is utilized to achieve the human emotion recognition. The experimental results indicate that the proposed method leads to good human emotion recognition, and the recognition accuracy is more than 66.67%.
Seeing Eye to Body

Scholars have long argued that women are denied a basic sense of humanness—are objectified—when focus is directed toward their physical rather than mental qualities. Early research on objectification focused on women’s self-objectification and measured objectification indirectly (as an emphasis on physical appearance). Recent research, however, has provided direct evidence that a focus on the physical aspects of women by others causes women to be perceived like, and act like, objects lacking mind. Manifestations of this literal objectification include attributing women less of the traits that distinguish people from objects and visual-recognition and neural responses consistent with nonhuman-object perception. Women themselves also behave more like objects (by, e.g., speaking less) when they are aware of this focus by others. Real-world implications and ways to defuse literal objectification are discussed.
Differentially methylated regions in maternal and paternal uniparental disomy for chromosome 7

DNA methylation is a hallmark of genomic imprinting and differentially methylated regions (DMRs) are found near and in imprinted genes. Imprinted genes are expressed only from the maternal or paternal allele and their normal balance can be disrupted by uniparental disomy (UPD), the inheritance of both chromosomes of a chromosome pair exclusively from only either the mother or the father. Maternal UPD for chromosome 7 (matUPD7) results in Silver-Russell syndrome (SRS) with typical features and growth retardation, but no gene has been conclusively implicated in SRS. In order to identify novel DMRs and putative imprinted genes on chromosome 7, we analyzed eight matUPD7 patients, a segmental matUPD7q31-qter, a rare patUPD7 case and ten controls on the Infinium HumanMethylation450K BeadChip with 30 017 CpG methylation probes for chromosome 7. Genome-scale analysis showed highly significant clustering of DMRs only on chromosome 7, including the known imprinted loci GRB10, SGCE/PEG10, and PEG/MEST. We found ten novel DMRs on chromosome 7, two DMRs for the predicted imprinted genes HOXA4 and GLI3 and one for the disputed imprinted gene PON1. Quantitative RT-PCR on blood RNA samples comparing matUPD7, patUPD7, and controls showed differential expression for three genes with novel DMRs, HOXA4, GLI3, and SVOPL. Allele specific expression analysis confirmed maternal only expression of SVOPL and imprinting of HOXA4 was supported by monoallelic expression. These results present the first comprehensive map of parent-of-origin specific DMRs on human chromosome 7, suggesting many new imprinted sites.
Treatment perspectives on interned mentally ill offenders in a forensic psychiatric center (FPC): a Delphi study on experts' opinions

The study aims to map the treatment perspectives of international experts on treating mentally ill offenders (MIO) in a forensic psychiatric centre (FPC) using the Delphi method. The four-round Delphi study reveals high conformity on the proposed treatment-related issues. However, some points of divergence remain. Three controversies underpinning these disagreements are discussed. The first regards the treatment and control debate, the second concerns the dual role of assessment in forensic mental health care and the third describes potential entry conditions for treatment in a FPC. Further research is needed to scientifically underpin the above mentioned debates. In this regard, the study suggests a close collaboration between practitioners and researchers.
Steroid-free Liver Transplantation Using Rabbit Antithymocyte Globulin Induction in 500 Consecutive Patients

Background We have previously documented the efficacy of a steroid-free immunosuppression protocol using rabbit antithymocyte globulin (RATG) induction in orthotopic liver transplantation (OLT) with tacrolimus minimization. The purpose of this report is to demonstrate the benefits of this protocol in a large cohort of patients. Methods We evaluated outcomes of 500 consecutive OLT recipients who received RATG induction and a single dose of solumedrol given before the first dose of RATG. Mycophenolate mofetil was initiated postoperatively with delayed initiation of tacrolimus. Sirolimus replaced tacrolimus if serum creatinine remained above 2.0 mg/dL by day 7. Patients were weaned to tacrolimus or sirolimus monotherapy at 3 months. Mean model for end-stage liver disease (MELD) at transplantation was 22 ± 6. Results Forty-four percent of patients had hepatitis C. Posttransplant creatinine was highest at 1 month (1.43 ± 0.95 mg/dL) and improved to 1.26 ± 0.60 mg/dL (P < 0.05) at 2.5 years. Glomerular filtration rate was lowest at 1 month (65.6 ± 30.0) and improved by 1 year (72.7 ± 28.2, P < 0.01). Tacrolimus was initiated at 4.79 ± 13.3 days with a level of 4.95 ± 2.45 ng/mL at 1 year. One-year patient and graft survival were 92.8% and 89.6%, respectively, with a 3-year patient survival of 82.9%. Rejection occurred in 114 (22.8%) patients, 33 (6.6%) patients requiring steroids. Univariate and multivariate Cox proportional hazard analyses were performed to evaluate the effects of donor and recipient characteristics on patient and graft survivals. Pretransplant creatinine was consistently a statistically significant predictor for patient and graft survival. Conclusion This is the largest reported series of OLT recipients using a steroid-free protocol with RATG induction demonstrating excellent outcomes, low complication rates, and preservation of renal function.