Miracle-dz/UniFAR-FTUs huggingface dataset:
Ibutilide versus amiodarone in atrial fibrillation: A double-blinded, randomized study

ObjectiveIbutilide, a class III antiarrhythmic drug, has been shown to convert atrial fibrillation to sinus rhythm more rapidly than procainamide or sotalol. Our objective was to compare the efficacy and safety of ibutilide and amiodarone in patients after cardiac surgery. DesignProspective, randomized, double-blinded study. SettingIntensive care unit of a university hospital. PatientsForty adults with an onset of atrial fibrillation within 3 hrs after admission. InterventionsBefore the administration of antiarrhythmic drugs, a 24-hr Holter electrocardiograph was attached. Patients in the ibutilide group received ibutilide 0.008 mg/kg body weight over 10 mins; treatment was repeated if atrial fibrillation or flutter persisted. If sinus rhythm was not achieved within 4 hrs, amiodarone 5 mg/kg was administered over 30 mins, followed by amiodarone 15 mg/kg over 24 hrs. Patients in the amiodarone group received amiodarone 5 mg/kg over 30 mins, followed by amiodarone 15 mg/kg over 24 hrs if atrial fibrillation or flutter continued. Measurements and Main ResultsWithin the first 4 hrs, atrial fibrillation was converted in nine of 20 patients (45%) in group ibutilide and in ten of 20 patients (50%) in group amiodarone (not significant). Mean time for conversion overall was 385 mins in group ibutilide and 495 mins in group amiodarone (not significant). In group amiodarone, the protocol was discontinued in two patients because of severe arterial hypotension. Atrial fibrillation recurred in 11 of 20 patients (55%) in group ibutilide and in seven of 20 patients (35%) in group amiodarone (not significant). Ventricular arrhythmia did not occur during the first 24 hrs of the protocol. ConclusionsIbutilide has no significant advantage over amiodarone for the conversion of atrial fibrillation to sinus rhythm in either time to conversion or conversion overall, but severe hypotension was not seen with ibutilide.
Urinary metabolites from mango (Mangifera indica L. cv. Keitt) galloyl derivatives and in vitro hydrolysis of gallotannins in physiological conditions.

SCOPE The absorption, metabolism, and excretion of mango galloyl derivatives (GD) has not yet been investigated in humans, and studies investigating repeated dosages of polyphenols are limited. METHODS AND RESULTS In this human pilot trial, healthy volunteers (age = 21-38 y, n = 11) consumed 400 g/day of mango-pulp (cv. Keitt) for 10 days, and seven metabolites of gallic acid (GA) were characterized and quantified in urine excreted over a 12 h period. Pyrogallol-O-sulfate and deoxypyrogallol-O-sulfate were found to be significantly more excreted between days 1 and 10 (p < 0.05) from 28.5 to 55.4 mg and 23.6 to 47.7 mg, respectively. Additionally, the in vitro hydrolysis of gallotannins (GTs) was monitored at physiological pH and temperature conditions, and after 4 h a significant (p < 0.05) shift in composition from relativity high to low molecular weight GTs was observed. CONCLUSION Seven metabolites of GA were identified in the urine of healthy volunteers, and two microbial metabolites were found to be significantly more excreted following 10 days of mango consumption. Mango GTs were also found to release free GA in conditions similar to the intestines. GTs may serve as a pool of pro-GA compounds that can be absorbed or undergo microbial metabolism.
Early respiratory infections and childhood asthma.

OBJECTIVE To assess the role of early respiratory infections in the development of bronchial obstruction in the first 2 years of life, and asthma by the age of 4 years in the Oslo Birth Cohort, established in 1992-1993. Having older siblings and attendance to a day care center were also considered as proxy measures of early infections. METHODS A total of 2531 children were followed from birth to 4 years of age. Experiences of respiratory infections were recorded in the follow-up surveys at 6 and 12 months of age, and children with symptoms and signs of bronchial obstruction during the first 2 years of life were identified and examined. The presence of current asthma was recorded when the children were 4 years old. RESULTS Children with respiratory infections during infancy had a higher risk of having bronchial obstruction during the first 2 years of life and of having asthma at 4 years of age. In logistic regression adjusting for confounders including other infections, the risk of asthma at 4 years of age was related to lower respiratory tract infection (odds ratio [OR]: 3.4; 95% confidence interval [CI]: 2.3-7.0), otitis media (OR: 1.8; 95% CI: 1.2-2.6), croup (OR: 2.1; 95% CI: 1.2-3.7) in the first year and related to the common cold (OR: 2.0; 95% CI: 1.3-3.1) in the first 6 months of life. The risk of current asthma was inversely related to older siblings after controlling for early respiratory infections. CONCLUSION Early respiratory infections indicate increased, rather than decreased, risk of developing bronchial obstruction during the first 2 years of life and of having asthma at 4 years of age.
CAPERα Is a Novel Rel-TAD-Interacting Factor That Inhibits Lymphocyte Transformation by the Potent Rel/NF-κB Oncoprotein v-Rel

ABSTRACT The Rel/NF-κB transcription factors are constitutively activated in many human cancers. The Rel proteins in this family are implicated in leukemia/lymphomagenesis, but the mechanism is not completely understood. Previous studies showed that the transcription activation domains (TADs) of the viral oncoprotein v-Rel and its cellular Rel/NF-κB homologues c-Rel and RelA are key determinants of their different transforming activities in primary lymphocytes. Substitution of a Rel TAD for that of RelA conferred a strong transforming phenotype upon RelA, which otherwise failed to transform cells. To gain insights into protein interactions that influence cell transformation by the Rel TADs, we identified factors that interact with the TAD of v-Rel, the most oncogenic member of the Rel/NF-κB family. We report that the coactivator for transcription factors AP-1 and estrogen receptors, CAPERα, interacts with the v-Rel TAD and potently synergizes v-Rel-mediated transactivation. Importantly, coexpression of CAPERα markedly reduced and delayed v-Rel's transforming activity in primary lymphocytes, whereas a dominant-negative mutant enhanced the kinetics of v-Rel-mediated transformation. Furthermore, small interfering RNA-mediated knockdown of CAPERα in v-Rel-transformed lymphocytes significantly enhanced colony formation in soft agar. Since the potency of Rel-mediated transactivation is an important determinant of lymphocyte transformation, as is Rel's ability to induce transcriptional repression, these data suggest that CAPERα's interaction with the Rel TAD could modulate Rel/NF-κB's transforming activity by facilitating expression or dampening repression of specific gene subsets important for oncogenesis. Overall, this study identifies CAPERα as a new transcriptional coregulator for v-Rel and reveals an important role in modulating Rel's oncogenic activity.
New angles on top quark decay to a charged Higgs

To properly discover a charged Higgs Boson (H? ) requires its spin and couplings to be determined. We investigate how to utilize t spin correlations to analyze the H? couplings in the decay t ? bH+ ? b? +? Within the framework of a general Two-Higgs-Doublet Model, we obtain results on the spin analyzing coefficients for this decay and study in detail its spin phenomenology, focusing on the limits of large and small values for tan ? Using a Monte Carlo approach to simulate full hadron-level events, we evaluate systematically how the H? decay mode can be used for spin analysis. The most promising observables are obtained from azimuthal angle correlations in the transverse rest frames of t(). This method is particularly useful for determining the coupling structure of H? in the large tan ? limit, where differences from the SM are most significant.
VERBAL INFLECTIONAL MORPHOLOGY IN BROCA'S APHASIA

The present study aims to explore the nature of agrammatism, the main symptom of Broca’s aphasia, by seeking to clarify if some of its characteristic grammatical errors are a consequence of selective impairment of functional categories. To examine this question, it focuses on the inflectional domain, i.e. Tense and Agreement in the verbal production of Catalan, English and Spanish agrammatic subjects. This issue is analysed within the theoretical framework of generative grammar. Pollock’s (1989) Split Inflection Hypothesis together with Friedmann and Grodzinsky’s (1997) Tree-Pruning Hypothesis will be the main hypotheses considered to analyse the data. Agrammatic speech is characterized by the omission or substitution of two main types of functional elements: inflectional morphemes and ‘free-standing function words’ (prepositions, determiners, auxiliaries and complementizers), which are selectively impaired. For bound morphemes, assuming that patients respect rules of lexical well-formedness (as established by Grodzinsky 1984, 1990), the grammatical properties of the language used mark in which cases omissions are impossible and substitutions take place. While in languages where inflection is attached to words (e.g. English), omissions are expected to occur, for languages which attach inflection to stems (e.g. Catalan or Spanish), substitutions are expected. The analysis of inflection in terms of a series of functional categories follows, within the framework of Principles and Parameters, from Pollock’s (1989) Split Inflection Hypothesis. Based on a study of inflected verbs in French and English, Pollock proposed the division of INFL into two separate functional nodes. Following
Peroxisome Proliferator-Activated Receptor Delta (PPARD) : Molecular studies of regulation and activation

The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors involved in energy homeostasis. Their natural ligands are fatty acids and there are three different PPAR isoforms; PPARA, PPARG and PPARD. They are encoded by separate genes and have distinct functions, due to different tissue expression and affinity for ligands. PPARA controls genes involved in fatty acid oxidation, PPARG regulates genes important for fatty acid storage, and PPARD controls genes implicated in lipid oxidation and lipoprotein metabolism. Primates and humans treated with a PPARD agonist (GW501516) resulted in improved insulin sensitivity, increased HDL and decreased LDL cholesterol levels, making it a putative drug candidate for treatment of metabolic disease. PPARD has recently been assigned a beneficial role in macrophages, by inducing a switch from proinflammatory (M1) to antiinflammatory (M2) macrophages. To characterize additional target genes of PPARD involved in the lipoprotein metabolism, the effect of PPARD activation on the apolipoprotein A-II (apoA-II) gene was investigated in human hepatoma cells. ApoA-II is one of the major proteins in the HDL particles. Treatment with GW501516 increased apoA-II promoter activity and mRNA levels in hepatoma cell lines. A site located at -737/-717 in the promoter was identified as the functional PPAR response element (PPRE). These results suggest that increased expression of the apoA-II gene is one of the reasons for the beneficial effects on lipoprotein metabolism after treatment with
Detection of bacteriocins of lactic acid bacteria isolated from foods and comparison with pediocin and nisin

A total of 663 533 colonies from 72 dairy and meat sources showed a detection rate of 0·2% for bacteriocin producers using direct plating techniques. A further 83 000 colonies from 40 fish and vegetable sources showed a detection rate of 3·4% for bacteriocin producers using selective enrichment procedures. A collection of seven purified isolates showing a different host spectrum of bacteriocin activity and with the ability to produce bacteriocins in broth culture were compared with nisin and pediocin (with respect to their inhibitory activity, determined by the critical dilution method), against various indicator bacteria in agar and broth. The sensitivity of Listeria species to various bacteriocins was influenced by the agar and broth test systems used. A Lactobacillus curvatus strain was found to be the most suitable indicator for quantitating antimicrobial effects of all the bacteriocins investigated in both agar and broth test systems. The bacteriocin‐producing isolates were characterized by biochemical reactions and DNA restriction enzyme profiles and taxonomic identification revealed species of Lactobacillus, Carnobacterium and Lactococcus assigned on the basis of 16S rDNA sequences.
Resistance rate to antibiotics of Helicobacter pylori isolates in eastern Taiwan

Background and Aim: Prevalence of Helicobacter pylori (H. pylori) strains resistant to metronidazole, clarithromycin and amoxicillin is increasing worldwide. The aim of this study was to determine the antibiotic susceptibility patterns in H. pylori strains isolated from eastern Taiwan.
Esthetic rehabilitation of single anterior edentulous space using fiber-reinforced composite

A fiber-reinforced composite (FRC) fixed prosthesis is an innovative alternative to a traditional metal restoration, as it is a conservative treatment method. This case report demonstrates a detailed procedure for restoring a missing anterior tooth with an FRC. A 44-year-old woman visited our department with an avulsed tooth that had fallen out on the previous day and was completely dry. This tooth was replanted, but it failed after one year. A semi-direct technique was used to fabricate a FRC fixed partial prosthesis for its replacement. The FRC framework and the pontic were fabricated using a duplicated cast model and nanofilled composite resin. Later on, interproximal contact, tooth shape, and shade were adjusted at chairside. This technique not only enables the clinician to replace a missing tooth immediately after extraction for minimizing esthetic problems, but it also decreases both tooth reduction and cost.
Vocal cord dysfunction and asthma

Purpose of review Vocal cord dysfunction can occur independently or can co-exist with asthma. It often mimics asthma in presentation and can be challenging to diagnose, particularly in those with known asthma. Vocal cord dysfunction remains under-recognized, which may result in unnecessary adjustments to asthma medicines and increased patient morbidity. There is a need to review current literature to explore current theories regarding disease presentation, diagnosis, and treatment. Recent findings The underlying cause of vocal cord dysfunction is likely multifactorial but there has been increased interest in hyper-responsiveness of the larynx. Many intrinsic and extrinsic triggers have been identified which in part may explain asthma-like symptomatology. A variety of techniques have been reported to provoke vocal cord dysfunction during testing which may improve diagnosis. There is a significant gap in the literature regarding specific laryngeal control techniques, duration of therapy, and the effectiveness of laryngeal control as a treatment modality. Summary Those with vocal cord dysfunction and asthma report more symptoms on standardized asthma control questionnaires, which can result in increasing amounts of medication if vocal cord dysfunction is not identified and managed appropriately. Clinicians need to maintain a high index of suspicion to identify these patients. Videolaryngostroboscopy remains the diagnostic method of choice. Evidence-based guidelines are needed for the most effective diagnostic techniques. Laryngeal control taught by speech pathologists is the most common treatment. Effectiveness is supported in case reports and clinical experience, but not in larger randomized trials which are needed.
Psychopathology and resilience following traumatic injury: a latent growth mixture model analysis.

OBJECTIVE To investigate trajectories of PTSD and depression following traumatic injury using latent class growth curve modeling. METHOD A longitudinal study of 330 injured trauma survivors was conducted and participants were assessed during hospitalization, and at 1, 3, and 6 months follow-up. Acute Stress Disorder (ASD) was assessed during hospitalization using the Acute Stress Disorder Interview (ASD-I), PTSD was measured at all follow-up with the Post-Traumatic Stress Diagnostic Scale (PDS) and depression was measured at hospitalization with the (BSI) and at follow-up with the Center for Epidemiologic Studies Depression Scale (CESDS). Covariates were explored, including coping self-efficacy, anger, education level, and mechanism of injury. RESULTS Four latent classes were identified for PTSD and Depression symptoms: chronic distress, delayed distress, recovered, and resilience. When compared to the resilient group, individuals with chronic distress were more likely to have been assaulted, had higher levels of anger, and had less coping self-efficacy. The delayed distress group had lower education levels, higher levels of coping self-efficacy, and higher levels of anger. Individuals in the recovered group had fewer years of education, and higher levels of anger. CONCLUSION The majority of the injured trauma sample demonstrated resiliency, with those exhibiting distress doing so as a delayed, chronic, or recovered trajectory. Coping self efficacy, education, assaultive trauma type, and anger were important covariates of depression and PTSD trajectories. These results are similar to studies of individuals who experienced a major health threat and with survivors from the World Trade Center attacks in the U.S.
Laminar selectivity of the cholinergic suppression of synaptic transmission in rat hippocampal region CA1: computational modeling and brain slice physiology

ACh may set the dynamics of cortical function to those appropriate for learning new information. In models of the putative associative memory function of piriform cortex, selective suppression of intrinsic but not afferent fiber synaptic transmission by ACh prevents recall of previous input from interfering with the learning of new input (Hasselmo, 1993). Selective cholinergic suppression may play a similar role in the hippocampal formation, where Schaffer collateral synapses in stratum radiatum (s. rad) may store associations between activity in region CA3 and the entorhinal cortex input to region CA1 terminating in stratum lacunosum-moleculare (s. l-m). A computational model of region CA1 predicts that for effective associative memory function of the Schaffer collaterals, cholinergic suppression of synaptic transmission should be stronger in s. rad than in s. l-m. In the hippocampal slice preparation, we tested the effect of the cholinergic agonist carbachol (0.01–500 microM) on synaptic transmission in s. rad and s. l-m. Stimulating and recording electrodes were simultaneously placed in both layers, allowing analysis of the effect of carbachol on synaptic potentials in both layers during the same perfusion in each slice. Carbachol produced a significantly stronger suppression of stimulus- evoked EPSPs in s. rad than in s. l-m at all concentrations greater than 1 microM. At 100 microM, EPSP initial slopes were suppressed by 89.1 +/- 3.0% in s. rad, but only by 40.1 +/- 4.1% in s. l-m. The muscarinic antagonist atropine (1 microM) blocked cholinergic suppression in both layers. These data support the hypothesis that synaptic modification of the Schaffer collaterals may store associations between activity in region CA3 and the afferent input to region CA1 from the entorhinal cortex. In simulations, feedback regulation of cholinergic modulation based on activity in region CA1 sets the appropriate dynamics of learning for novel associations, and recall for familiar associations.
How to Develop a Coaching Eye.

As schools and districts explore how coaching fits into their professional development plans, they must identify the essential skills and supports needed for this complex role. Teachers, school leaders, and coaches must begin by asking: What skills are needed for coaching? What coaching strategies enhance the coach-teacher interaction? What kinds of support do coaches need? And teachers and staff developers taking on this assignment have to learn to look at what's happening in the classroom using a "coaching eye" instead of a "teaching eye. "
Inhibition of calcium spikes and transmitter release by γ‐aminobutyric acid in the guinea‐pig myenteric plexus

1 The effect of γ‐aminobutyric acid (GABA) (1 μM‐1 mM) on synaptic transmission in isolated myenteric ganglia of guinea‐pig ileum was investigated with intracellular recording techniques. 2 GABA (up to 1 mM) had no effect on the resting membrane potential and membrane conductance of S neurones. 3 GABA reduced the amplitude of the fast excitatory postsynaptic potential (e.p.s.p.) without changing the amplitude of the nicotinic response to ionophoretic application of acetylcholine (ACh). This effect was mimicked by baclofen (10–100 μM) and was not blocked by bicuculline (10 μM). The preparation did not become desensitized during prolonged GABA applications. 4 Cholinergic and non‐cholinergic slow e.p.s.ps evoked by single or repetitive presynaptic nerve stimulation were reduced in amplitude by GABA. GABA did not depress muscarinic responses to ionophoretic application of ACh. 5 GABA reduced the duration of the action potential in AH neurones in concentrations that did not affect the membrane potential or conductance. The effect was very marked when electrodes were filled with CsCl, and tetrodotoxin was in the supervising solution. This effect was also mimicked by baclofen, was insensitive to bicuculline and was not reduced with repeated application or GABA. 6 It is concluded that GABA inhibits release of ACh and the transmitter mediating the slow e.p.s.p. This effect may result from inhibition of an inward calcium current.
Understanding adolescent girls’ vulnerability to the impact of the mass media on body image and restrained eating behaviour: the role of media type, body perfect internalisation and materialism

There is a strong body of psychological research implicating the mass media in the aetiology of adolescent girls’ negative body image and eating behaviours. The present thesis aims to extend this research by examining potential factors – namely, media type, body perfect internalisation and materialism – that make girls more vulnerable to the negative impact of the mass media. An initial meta-analysis (Chapter 3) collated the findings of existing research examining the impact of ‘body perfect’ media on adolescents’ body image; examining gender, age and media type as moderators of this effect. Chapter 4 examined the relative roles of both media type and media model identification (a key dimension of body perfect internalisation), within the mass media and body image relationship. Using both survey and experimental methods (N = 199), it was found that adolescent girls’ habitual tendency to identify with media models, was a more potent vulnerability factor within the mass media and body image relationship, than media type. Due to the limitations associated with existing measures of body perfect internalisation, a new measure of body perfect internalisation was developed in Chapter 5 (N =373), which was subsequently utilised in the final experiments of the thesis. Chapter 6 demonstrated that acute music video exposure had a more potent negative impact on girls’ body image than still media images (N = 142); an effect that was fully mediated by wishful character identification and also moderated by body perfect internalisation. Chapter 7 consists of two studies that demonstrate the important role which materialism plays within the mass media, body image and eating behaviour relationship. In Study 1, structural equation modelling identified a direct pathway between materialism and restrained eating that was independent of body image (N = 199). This finding was further replicated in an exposure experiment, which demonstrated that brief exposure to materialistic media causes acute diet-like behaviours in adolescent girls (N = 180).