Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic Diversity and Distribution Patterns of Host Insects of Caterpillar Fungus Ophiocordyceps sinensis in the Qinghai-Tibet Plateau

The caterpillar fungus Ophiocordyceps sinensis is one of the most valuable medicinal fungi in the world, and it requires host insects in family Hepialidae (Lepidoptera) to complete its life cycle. However, the genetic diversity and phylogeographic structures of the host insects remain to be explored. We analyzed the genetic diversity and temporal and spatial distribution patterns of genetic variation of the host insects throughout the O. sinensis distribution. Abundant haplotype and nucleotide diversity mainly existed in the areas of Nyingchi, ShangriLa, and around the edge of the Qinghai-Tibet Plateau, where are considered as the diversity center or micro-refuges of the host insects of O. sinensis. However, there was little genetic variation among host insects from 72.1% of all populations, indicating that the host species composition might be relatively simple in large-scale O. sinensis populations. All host insects are monophyletic except for those from four O. sinensis populations around Qinghai Lake. Significant phylogeographic structure (NST>GST, P<0.05) was revealed for the monophyletic host insects, and the three major phylogenetic groups corresponded with specific geographical areas. The divergence of most host insects was estimated to have occurred at ca. 3.7 Ma, shortly before the rapid uplift of the QTP. The geographical distribution and star-like network of the haplotypes implied that most host insects were derived from the relicts of a once-widespread host that subsequently became fragmented. Neutrality tests, mismatch distribution analysis, and expansion time estimation confirmed that most host insects presented recent demographic expansions that began ca. 0.118 Ma in the late Pleistocene. Therefore, the genetic diversity and distribution of the present-day insects should be attributed to effects of the Qinghai-Tibet Plateau uplift and glacial advance/retreat cycles during the Quaternary ice age. These results provide valuable information to guide the protection and sustainable use of these host insects as well as O. sinensis.
TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action

OBJECTIVE Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk. RESEARCH DESIGN AND METHODS Eight subjects with risk-conferring TCF7L2 genotypes (TT or TC at rs7903146) and 10 matched subjects with wild-type genotype (CC) underwent 5-h oral glucose tolerance test (OGTT), isoglycemic intravenous glucose infusion, and graded glucose infusion (GGI). Mathematical modeling was used to quantify insulin-secretory profiles during OGTT and glucose infusion protocols. The incretin effect was assessed from ratios of the insulin secretory rates (ISR) during oral and isoglycemic glucose infusions. Dose-response curves relating insulin secretion to glucose concentrations were derived from the GGI. RESULTS β-cell responsivity to oral glucose was 50% lower (47 ± 4 vs. 95 ± 15 × 109 min−1; P = 0.01) in the group of subjects with risk-conferring TCF7L2 genotypes compared with control subjects. The incretin effect was also reduced by 30% (32 ± 4 vs. 46 ± 4%; P = 0.02) in the at-risk group. The lower incretin effect occurred despite similar glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) responses to oral glucose. The ISR response to intravenous glucose over a physiologic glucose concentration range (5–9 mmol/l) was similar between groups. CONCLUSIONS The TCF7L2 variant rs7903146 appears to affect risk of type 2 diabetes, at least in part, by modifying the effect of incretins on insulin secretion. This is not due to reduced secretion of GLP-1 and GIP but rather due to the effect of TCF7L2 on the sensitivity of the β-cell to incretins. Treatments that increase incretin sensitivity may decrease the risk of type 2 diabetes.
Ranking of hazardous road locations in two-lane two-way rural roads with no crash record

Crash data availability is a significant requirement for identifying hazardous roads. However, for roads with poor data sets or no crash record, a method is needed to find and rank road segments independent of the crash records. In this paper, an auditing based methodology is proposed to determine the hazardous locations. A Rural road is investigated by decomposing it first into six elements, and then into safety factors corresponding to each element. The elements are: straight segments, horizontal and vertical curves, bridges, tunnels, merges and intersections, and side road land use. The relative contribution of the elements to the safety of a road segment is determined using the Analytical Hierarchy Process (AHP) via a system of weights which are suggested by an expert panel. Subject to a consistency test of the expert responses, AHP determines the weight of elements. In an independent survey, roads are audited and ranked with respect to their elements. The weighted sum of these ranks is used to calculate a Safety Index (SI) for a road segment. Road segments with the lowest values of SI are identified as the most hazardous locations.
Deep Learning for Music

Our goal is to be able to build a generative model from a deep neural network architecture to try to create music that has both harmony and melody and is passable as music composed by humans. Previous work in music generation has mainly been focused on creating a single melody. More recent work on polyphonic music modeling, centered around time series probability density estimation, has met some partial success. In particular, there has been a lot of work based off of Recurrent Neural Networks combined with Restricted Boltzmann Machines (RNN-RBM) and other similar recurrent energy based models. Our approach, however, is to perform end-to-end learning and generation with deep neural nets alone.
Epigenome-Microbiome crosstalk: A potential new paradigm influencing neonatal susceptibility to disease

ABSTRACT Preterm birth is the leading cause of infant morbidity and mortality. Necrotizing enterocolitis (NEC) is an inflammatory bowel disease affecting primarily premature infants, which can be lethal. Microbial intestinal colonization may alter epigenetic signatures of the immature gut establishing inflammatory and barrier properties predisposing to the development of NEC. We hypothesize that a crosstalk exists between the epigenome of the host and the initial intestinal colonizing microbiota at critical neonatal stages. By exposing immature enterocytes to probiotic and pathogenic bacteria, we showed over 200 regions of differential DNA modification, which were specific for each exposure. Reciprocally, using a mouse model of prenatal exposure to dexamethasone we demonstrated that antenatal treatment with glucocorticoids alters the epigenome of the host. We investigated the effects on the expression profiles of genes associated with inflammatory responses and intestinal barrier by qPCR-based gene expression array and verified the DNA modification changes in 5 candidate genes by quantitative methylation specific PCR (qMSP). Importantly, by 16S RNA sequencing-based phylogenetic analysis of intestinal bacteria in mice at 2 weeks of life, we showed that epigenome changes conditioned early microbiota colonization leading to differential bacterial colonization at different taxonomic levels. Our findings support a novel conceptual framework in which epigenetic changes induced by intrauterine influences affect early microbial colonization and intestinal development, which may alter disease susceptibility.
An OMV Vaccine Derived from a Capsular Group B Meningococcus with Constitutive FetA Expression: Preclinical Evaluation of Immunogenicity and Toxicity

Following the introduction of effective protein-polysaccharide conjugate vaccines against capsular group C meningococcal disease in Europe, meningococci of capsular group B remain a major cause of death and can result in debilitating sequelae. The outer membrane proteins PorA and FetA have previously been shown to induce bactericidal antibodies in humans. Despite considerable antigenic variation among PorA and FetA OMPs in meningococci, systematic molecular epidemiological studies revealed this variation is highly structured so that a limited repertoire of antigenic types is congruent with the hyperinvasive meningococcal lineages that have caused most of the meningococcal disease in Europe in recent decades. Here we describe the development of a prototype vaccine against capsular group B meningococcal infection based on a N. meningitidis isolate genetically engineered to have constitutive expression of the outer membrane protein FetA. Deoxycholate outer membrane vesicles (dOMVs) extracted from cells cultivated in modified Frantz medium contained 21.8% PorA protein, 7.7% FetA protein and 0.03 μg LPS per μg protein (3%). The antibody response to the vaccine was tested in three mouse strains and the toxicological profile of the vaccine was tested in New Zealand white rabbits. Administration of the vaccine, MenPF-1, when given by intramuscular injection on 4 occasions over a 9 week period, was well tolerated in rabbits up to 50 μg/dose, with no evidence of systemic toxicity. These data indicated that the MenPF-1 vaccine had a toxicological profile suitable for testing in a phase I clinical trial.
Psychiatric Comorbidity at the Time of Diagnosis in Adults With ADHD

Objective: The CAT (Comorbilidad en Adultos con TDAH) study aimed to quantify and characterize the psychiatric comorbidity at the time of diagnosis of ADHD in adult outpatients. Method: Cross-sectional, multicenter, observational register of adults with ADHD diagnosed for the first time. Results: In this large sample of adult ADHD (n = 367), psychiatric comorbidities were present in 66.2% of the sample, and were more prevalent in males and in the hyperactive-impulsive and combined subtypes. The most common comorbidities were substance use disorders (39.2%), anxiety disorders (23%), and mood disorders (18.1%). In all, 88.8% patients were prescribed pharmacological treatment for ADHD (in 93.4% of cases, modified release methylphenidate capsules 50:50). Conclusion: A high proportion of psychiatric comorbidity was observed when adult outpatients received a first-time diagnosis of ADHD. The systematic registering of patients and comorbidities in clinical practice may help to better understand and manage the prognostic determinants in adult ADHD.
Analysis of handwriting of children during treatment for acute lymphoblastic leukemia.

BACKGROUND Children treated for acute lymphoblastic leukemia (ALL) often complain about handwriting problems. PROCEDURE Using a computerized writing task, we have prospectively studied the processes necessary for the production of handwriting movements in 11 children (5-12 years old) during treatment for ALL. Children were tested at time points closely related to the vincristine administration. RESULTS AND CONCLUSIONS Children treated for ALL drew slower, with longer pause durations and increased drawing pressure. Children were able to overcome the problems, except for a consistently increased drawing pressure. This increased drawing pressure may be an attempt of the children to obtain sufficient kinesthetic information and thus can be seen as an adequate adaptation mechanism in case of peripheral neuropathy due to the neurotoxic effects of vincristine. However, neurotoxic effects of other cytostatic drugs cannot be excluded.
Generalized Frequency Division Multiplexing for 5th Generation Cellular Networks

Cellular systems of the fourth generation (4G) have been optimized to provide high data rates and reliable coverage to mobile users. Cellular systems of the next generation will face more diverse application requirements: the demand for higher data rates exceeds 4G capabilities; battery-driven communication sensors need ultra-low power consumption; and control applications require very short response times. We envision a unified physical layer waveform, referred to as generalized frequency division multiplexing (GFDM), to address these requirements. In this paper, we analyze the main characteristics of the proposed waveform and highlight relevant features. After introducing the principles of GFDM, this paper contributes to the following areas: 1) the means for engineering the waveform's spectral properties; 2) analytical analysis of symbol error performance over different channel models; 3) concepts for MIMO-GFDM to achieve diversity; 4) preamble-based synchronization that preserves the excellent spectral properties of the waveform; 5) bit error rate performance for channel coded GFDM transmission using iterative receivers; 6) relevant application scenarios and suitable GFDM parameterizations; and 7) GFDM proof-of-concept and implementation aspects of the prototype using hardware platforms available today. In summary, the flexible nature of GFDM makes this waveform a suitable candidate for future 5G networks.
Magnetic Nanoparticles: Surface Effects and Properties Related to Biomedicine Applications

Due to finite size effects, such as the high surface-to-volume ratio and different crystal structures, magnetic nanoparticles are found to exhibit interesting and considerably different magnetic properties than those found in their corresponding bulk materials. These nanoparticles can be synthesized in several ways (e.g., chemical and physical) with controllable sizes enabling their comparison to biological organisms from cells (10–100 μm), viruses, genes, down to proteins (3–50 nm). The optimization of the nanoparticles’ size, size distribution, agglomeration, coating, and shapes along with their unique magnetic properties prompted the application of nanoparticles of this type in diverse fields. Biomedicine is one of these fields where intensive research is currently being conducted. In this review, we will discuss the magnetic properties of nanoparticles which are directly related to their applications in biomedicine. We will focus mainly on surface effects and ferrite nanoparticles, and on one diagnostic application of magnetic nanoparticles as magnetic resonance imaging contrast agents.
Perceptual decision making: drift-diffusion model is equivalent to a Bayesian model

Behavioral data obtained with perceptual decision making experiments are typically analyzed with the drift-diffusion model. This parsimonious model accumulates noisy pieces of evidence toward a decision bound to explain the accuracy and reaction times of subjects. Recently, Bayesian models have been proposed to explain how the brain extracts information from noisy input as typically presented in perceptual decision making tasks. It has long been known that the drift-diffusion model is tightly linked with such functional Bayesian models but the precise relationship of the two mechanisms was never made explicit. Using a Bayesian model, we derived the equations which relate parameter values between these models. In practice we show that this equivalence is useful when fitting multi-subject data. We further show that the Bayesian model suggests different decision variables which all predict equal responses and discuss how these may be discriminated based on neural correlates of accumulated evidence. In addition, we discuss extensions to the Bayesian model which would be difficult to derive for the drift-diffusion model. We suggest that these and other extensions may be highly useful for deriving new experiments which test novel hypotheses.
The electrical properties of liquid semiconductors

Abstract The Hall coefficient and the conductivity have been measured as a function of temperature for liquid Au2Te, CuTe and AgTe and as a function of temperature and composition for the liquid alloy systems Bi-Te and Tl-Te. The electrical properties of liquid Cu-Te, Ag-Te and Tl-Te seem to resemble those of a heavily doped semiconductor. The thermoelectric power data of Cutler and Mallon and of Dancy suggest that both p and n-type conduction occurs in these materials, depending on the composition. By contrast the Hall coefficient appears to be consistently negative and several explanations of this discrepancy are discussed.
Effects of Aeration on the Quality of Popcorn

Gentle in-store drying of popping corn may reduce the risk of stress fissures being generated, an effect which reduces popcorn expansion volume. In order to allow optimisation studies of in-store drying to be conducted, thermophysical properties of two current Australian popping corn varieties were measured in the range 30-50°C, at moisture contents from 12% to 20% wb. Models were developed for moisture isotherms, true density, bulk density, pressure drop and thin layer drying rate.
Modelling national HIV/AIDS epidemics: revised approach in the UNAIDS Estimation and Projection Package 2011

Objective United Nations Programme on HIV/AIDS reports regularly on estimated levels and trends in HIV/AIDS epidemics, which are evaluated using an epidemiological model within the Estimation and Projection Package (EPP). The relatively simple four-parameter model of HIV incidence used in EPP through the previous round of estimates has encountered challenges when attempting to fit certain data series on prevalence over time, particularly in settings with long running epidemics where prevalence has increased recently. To address this, the most recent version of the modelling package (EPP 2011) includes a more flexible epidemiological model that allows HIV infection risk to vary over time. This paper describes the technical details of this flexible approach to modelling HIV transmission dynamics within EPP 2011. Methodology For the flexible modelling approach, the force of infection parameter, r, is allowed to vary over time through a random walk formulation, and an informative prior distribution is used to improve short-term projections beyond the last year of data. Model parameters are estimated using a Bayesian estimation approach in which models are fit to HIV seroprevalence data from surveillance sites. Results This flexible model can yield better estimates of HIV prevalence over time in situations where the classic EPP model has difficulties, such as in Uganda, where prevalence is no longer falling. Based on formal out-of-sample projection tests, the flexible modelling approach also improves predictions and CIs for extrapolations beyond the last observed data point. Conclusions We recommend use of a flexible modelling approach where data are sufficient (eg, where at least 5 years of observations are available), and particularly where an epidemic is beyond its peak.
A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Maladaptive reward memories (MRMs) can become unstable following retrieval under certain conditions, allowing their modification by subsequent new learning. However, robust (well-rehearsed) and chronologically old MRMs, such as those underlying substance use disorders, do not destabilize easily when retrieved. A key determinate of memory destabilization during retrieval is prediction error (PE). We describe a retrieval procedure for alcohol MRMs in hazardous drinkers that specifically aims to maximize the generation of PE and therefore the likelihood of MRM destabilization. The procedure requires explicitly generating the expectancy of alcohol consumption and then violating this expectancy (withholding alcohol) following the presentation of a brief set of prototypical alcohol cue images (retrieval + PE). Control procedures involve presenting the same cue images, but allow alcohol to be consumed, generating minimal PE (retrieval-no PE) or generate PE without retrieval of alcohol MRMs, by presenting orange juice cues (no retrieval + PE). Subsequently, we describe a multisensory disgust-based counterconditioning procedure to probe MRM destabilization by re-writing alcohol cue-reward associations prior to reconsolidation. This procedure pairs alcohol cues with images invoking pathogen disgust and an extremely bitter-tasting solution (denatonium benzoate), generating gustatory disgust. Following retrieval + PE, but not no retrieval + PE or retrieval-no PE, counterconditioning produces evidence of MRM rewriting as indexed by lasting reductions in alcohol cue valuation, attentional capture, and alcohol craving.
Representing Continuous Change in the Event Calculus

The Event Calculus of Kowalski and Sergot only deals with discrete change. This paper introduces a simplified version of the Event Calculus and extends it to deal with continuous change, as in the height of a falling object or the level of liquid in a filling vessel. The idea of autotermination is introduced. A period of continuous change autoterminates if it brings about the event which terminates it. For example, when the increasing level of water in a sink reaches the overflow, it ceases to increase. The formulation is applied to a simple example with liquid filling a sink, and to a more complicated one with many tanks discharging liquid into another tank. In Proceedings ECAI 90, pages 598-603
Journal of the ceramic society of Japan = 窯業協会誌 : セラミックスと材料科学

Synthesis of gallium nitride nano-particles by ammonia nitridation of mixed ¢ -gallium oxide and gallium nitride powders Vol. 128, 10, The cover presents the synthesis process of gallium nitride (GaN) nanoparticles from mixed ¢ -gallium oxide (Ga 2 O 3 ) and GaN powders. Ammonia nitridation of ¢ -Ga 2 O 3 proceed via gas phase species. When GaN is added in advance, the size of ¢ -Ga 2 O 3 particles becomes smaller, which lead to the formation of GaN nanoparticles.
P‐4: Metal Contact Improvement in Cu‐gate TFT‐LCD

It was found that the extremely high contact resistance between Cu and ITO is caused by the damage of Cu during the via hole etching using SF6 and O2 plasma. TEM and XPS analysis indicate that an etching by‐product composed principally Cu2O was formed on the Cu film after the via etching. The result of a 3‐level 4‐factor Taguchi design showed that SF6/O2 ratio is the key parameter for the Cu dry etching. The Cu etching rate increases with decreasing the SF6/O2 ratio. By a via etching with high SF6/O2, Cu2O formation could be suppressed. The via contact resistance between Cu and ITO could be improved as same as that in the conventional Al gate metal.
An epidemiological approach to depression prevention in old age.

OBJECTIVE To identify target groups for prevention of chronic or recurrent depression in old age such that prevention is likely to become cost-effective. METHODS Data were used from a population-based cohort study (N = 2,200). Chronic or recurrent depression was defined when people presented with clinically high levels of depression at two time points separated by 3 years. Risk profiles of these conditions were identified using classification and regression trees analysis. The combinations of risk factors were then evaluated in multivariate models to ascertain their utility for preventing depression in high-risk groups. RESULTS People are placed at a high risk of depression when having symptoms of anxiety, functional impairments, two or more chronic illnesses, and either a low attained educational level or below average levels of mastery, while living without a partner. These risk profiles correspond with groups no larger than 8.3% of the older population. Containing the adverse effects of the risk factors would help to reduce the incidence of depression by possibly as much as 48.7%, indicating that large health gains can be generated, which can also be done efficiently with numbers-needed-to-be-treated, perhaps as small as three. CONCLUSION Targeting prevention on the selected high-risk groups is likely to become a cost-effective endeavor, because optimal health gains can be generated efficiently in groups small enough to be logistically manageable. The burden of illness associated with depression, particularly depression, in aging populations underscores the public health significance of such an approach.