Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunohistochemical Detection of Brucella Melitensis Antigens in Cases of Naturally Occurring Abortions in Sheep

Brucella melitensis, a worldwide zoonotic pathogen, is a significant cause of abortion in sheep and goats in some countries. The present study was carried out to determine, by immunohistochemistry, the presence of B. melitensis antigens in 110 naturally occurring aborted sheep fetuses. Sections of lung, liver, kidney, and spleen of each fetus were stained with immunoperoxidase to detect Brucella antigens. Brucella melitensis antigens were detected in 33 of 110 fetuses (30%). In the 33 positive cases, Brucella antigens were found in lung (25 [22.7%]), liver (21 [19%]), spleen (13 [11.8%]), and kidney (6 [5.4%]). Microscopic studies demonstrated that Brucella antigens were mainly located in the cytoplasm of macrophages and neutrophils of the lung, and in the cytoplasm of macrophages in the portal infiltrates and Kupffer cells of the liver. It was concluded that immunohistochemistry in formalin-fixed, paraffin-embedded tissues is a useful tool for the diagnosis of spontaneous ovine abortion caused by B. melitensis.
Organochlorine in the serum of inhabitants living near an electrochemical factory.

OBJECTIVES: To measure the impact of occupational and lifestyle factors on concentrations of organochlorine compounds in a general population sample living near an electrochemical factory with a high airborne concentration of hexachlorobenzene (HCB). METHODS: Serum samples from 608 people (328 selected from a random sample) were collected in 1994. Information on lifestyles, occupation, and medical condition was obtained by questionnaire. RESULTS: HCB and polychlorinated biphenyls (PCBs) were detected in all samples (means 36.7 ng/ml and 4.3 ng/ml respectively), followed by dichlorodiphenyl dichloroethane (DDE) and beta-hexachlorocyclohexane (beta-HCH), found in 98.7% and 87.3% of the samples respectively (means 4.6 ng/ml and 2.5 ng/ml, respectively). Concentrations of HCB were the highest ever reported. Occupation in the factory was the main determinant of the variation in concentrations of HCB (regression coefficients 1.52 (SEM 0.14) in 1n (HCB) for workers in the production department, and 2.13 (0.23) for workers in maintenance department) and explained the highest concentrations of HCB found in men of middle age. In retired workers, concentrations of HCB declined with time since retirement. The PCBs, dichlorodiphenyl trichloroethane (DDT), and beta-HCH were independent of the occupation and concentrations were similar to those found in other populations. Concentrations of beta-HCH and DDE in the whole population, and HCB among non-workers, were higher in women than in men. Concentrations of all measured organochlorine compounds increased with age and body mass index. Consumption of locally caught fish was an independent determinant of HCB and PCB concentrations. CONCLUSIONS: This population incorporated HCB directly through occupation in the electrochemical factory, by airborne pollution, and consumption of locally caught fish. Concentrations of other common organochlorine compounds were not higher than expected. Environmental exposures to these compounds deserve attention due to their persistence and potential health effects.
Personalized Persuasion for Social Interactions in Nursing Homes

This paper presents our preliminary investigation and approach towards a mixed physical-virtual technology for stimulating social interactions among and with older adults in nursing homes. We report on set of surveys, apps and focus groups aiming at understanding the different motivations and obstacles in promoting social interactions in institutionalised care. We then present our approach to address some of the key themes found, e.g., the technological disparity, lack of conversation topics and opportunities to interact
Black Immigrants

The history of what today is called the United States of America has been from the very beginning characterized by close relations between immigration and inequality. Many of the first European immigrants who came to the colony emerged from situations in which they were struggling to evade political or religious inequality; others were brought here as social, political, and economic unequals to further serve in inequality as bondsmen on the plantations. Then came the thousands of Africans, who were brought here by force because they were defined, among other things, as racial unequals. They were contained in a system structured
Moral worry and religiosity in US and Canadian college samples

The objective of this study was to investigate the presence of worry about personal moral attitudes and behaviors in two college samples, and to check associations with religiosity, age, gender, personality traits, and geographic region. The study sample was drawn from college students in Minneapolis, Minnesota (N = 333) and Sydney, Nova Scotia (N = 137). Instruments consisted of moral worry and religiosity questionnaires, and the Eysenck Personality Questionnaire. Principal-components analysis was used to develop components for the worry and religiosity scales, and MANOVA for correlations between variables. Moral worry emerged as a domain distinct from worry about practical issues. Moral worry was not related to religiosity, age, gender, or Eysenck personality traits. Whereas the US sample scored higher in religiosity than the Canadian sample, the Canadian sample scored higher on moral worry. The present study supports our previous work and that of others that worry about one's moral emotions and behaviors is an important aspect of daily life. As such, consideration should be given to including some inquiry about moral worries (guilt, shame, regret, remorse, and others) in psychiatric assessments.
Parental religiosity, family processes, and youth competence in rural, two-parent African American families.

A model that linked parental formal religiosity to children's academic competence and socioemotional adjustment during early adolescence was tested. The sample included 90 9- to 12-year-old African American youths and their married parents living in the rural South. The theoretical constructs in the model were measured through a multimethod, multi-informant design. Rural African American community members participated in the development of the self-report instruments and observational research methods. Greater parental religiosity led to more cohesive family relationships, lower levels of interparental conflict, and fewer externalizing and internalizing problems in the adolescents. Formal religiosity also indirectly influenced youth self-regulation through its positive relationship with family cohesion and negative relationship with interparental conflict.
Structural determinants of Third World urban change: an ecological and political economic analysis.

Quantitative cross-national studies of peripheral urbanization have been rooted in human ecology or political economy. Studies in the human ecology tradition cite rural adversity as a major determinant of Third World urban growth. Studies in the political economy mode emphasize economic dependency. This paper 1) argues that no quantitative analysis of Third World urbanization can be complete if it fails to incorporate determinants suggested by 1 or the other theory and 2) conducts such a "complete" quantitative cross-national analysis which examines simultaneously both rural adversity and dependency as predictors of urban change. Findings suggest that both factors are important. (authors)
Does the Punitive Need the Supportive? A Sympathetic Critique of Current Grammars of Urban Injustice

This paper is a sympathetic critique of mainstream grammars of urban injustice, arguing that they are frequently too one-sided and selective to adequately grasp the full complexity of urban realities. Most prominently, I contend that urban injustice and punitiveness co-exist with, if not sometimes depend upon, more supportive responses within urban space. I therefore counterbalance the spectacular logics of punitive urbanism and the everyday logics of control with a tripartite approach to logics assembled within the urban voluntary sector (abeyance, care and survival) as a way to reconnect to a broader set of practices. Two case studies are used to illustrate these contentions.
Role of Myo/Nog Cells in Neuroprotection: Evidence from the Light Damaged Retina

Purpose To identify Myo/Nog cells in the adult retina and test their role in protecting retinal photoreceptors from light damage. Methods Light damage was induced by exposing albino rats raised in dim cyclic light to 1000 lux light for 24 hours. In one group of rats, Myo/Nog cells were purified from rat brain tissue by magnetic cell sorting following binding of the G8 monoclonal antibody (mAb). These cells were injected into the vitreous humour of the eye within 2 hours following bright light exposure. Retinal function was assessed using full-field, flash electroretinogram (ERG) before and after treatment. The numbers of Myo/Nog cells, apoptotic photoreceptors, and the expression of glial fibrillary acidic protein (GFAP) in Muller cells were assessed by immunohistochemistry. Results Myo/Nog cells were present in the undamaged retina in low numbers. Light induced damage increased their numbers, particularly in the choroid, ganglion cell layer and outer plexiform layer. Intravitreal injection of G8-positive (G8+) cells harvested from brain mitigated all the effects of light damage examined, i.e. loss of retinal function (ERG), death of photoreceptors and the stress-induced expression of GFAP in Muller cells. Some of the transplanted G8+ cells were integrated into the retina from the vitreous. Conclusions Myo/Nog cells are a subpopulation of cells that are present in the adult retina. They increase in number in response to light induced stress. Intravitreal injection of Myo/Nog cells was protective to the retina, in part, by reducing retinal stress as measured by the Muller cell response. These results suggest that Myo/Nog cells, or the factors they produce, are neuroprotective and may be therapeutic in neurodegenerative retinal diseases.
Non‐physical forms of bullying among school pupils: a cause for concern

Considers which behaviours pupils and teachers regard as bullying. Finds that a substantial proportion of people fail to include non‐physical acts ‐ such as deliberately leaving somebody out of activities, laughing at someone’s misfortunes, and name‐calling ‐ in their definition of bullying. Reports on the frequency with which various behaviours were experienced by young people, and how they might affect standardized measures of psychological wellbeing. Finds that many children were bullied in non‐physical ways, and that these experiences were associated with psychological disturbances. Suggests that health educators should do more to widen teachers’ and pupils’ conceptions of bullying to include non‐physical acts of violence, and to encourage schools and other institutions to do more to combat them.
Using multiple sources of evidence to reason about history.

This article investigated whether students' ability to reason with and about documentary evidence is influenced by the composition of the document set they study. Two groups of college students read sets of history documents containing a variety of document types (e.g., historian essays, participant accounts). One group was also given primary documents, and the other group received additional historian essays that cited the primary documents. The students' task was to read the documents, rate their usefulness and trustworthiness, and write a short opinion essay on the controversy described in the documents. Results revealed that the presence of primary documents influenced how students rated the documents and on which criteria they based this interpretation. These results suggest that exposing students to a variety of document types, especially primary documents, within a reasoning task changes how students represent and reason about documents and historical problems.
TrueSkillTM: A Bayesian Skill Rating System

We present a new Bayesian skill rating system which can be viewed as a generalisation of the Elo system used in Chess. The new system tracks the uncertainty about player skills, explicitly models draws, can deal with any number of competing entities and can infer individual skills from team results. Inference is performed by approximate message passing on a factor graph representation of the model. We present experimental evidence on the increased accuracy and convergence speed of the system compared to Elo and report on our experience with the new rating system running in a large-scale commercial online gaming service under the name of TrueSkill.
High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease

Polycystic kidney disease (PKD) is a prevalent disorder characterized by renal cysts that lead to kidney failure. Various signaling pathways have been targeted to stop disease progression, but most interventions still focus on alleviating PKD-associated symptoms. The mechanistic complexity of the disease, as well as the lack of functional in vitro assays for compound testing, has made drug discovery for PKD challenging. To identify modulators of PKD, Pkd1–/– kidney tubule epithelial cells were applied to a scalable and automated 3D cyst culture model for compound screening, followed by phenotypic profiling to determine compound efficacy. We used this screening platform to screen a library of 273 kinase inhibitors to probe various signaling pathways involved in cyst growth. We show that inhibition of several targets, including aurora kinase, CDK, Chk, IGF-1R, Syk, and mTOR, but, surprisingly, not PI3K, prevented forskolin-induced cyst swelling. Additionally, we show that multiparametric phenotypic classification discriminated potentially undesirable (i.e., cytotoxic) compounds from molecules inducing the desired phenotypic change, greatly facilitating hit selection and validation. Our findings show that a pathophysiologically relevant 3D cyst culture model of PKD coupled to phenotypic profiling can be used to identify potentially therapeutic compounds and predict and validate molecular targets for PKD.
Application of Contact Graph Routing to LEO satellite DTN communications

Delay-/Disruption-Tolerant Networking, which originated from research on deep space communications, has enlarged its scope to encompass all challenged networks, including LEO satellite communications. Focusing on single satellite or incomplete constellation cases, the advantages of DTN mainly relate to its ability to cope with disruption and intermittent connectivity, typical of LEOs. This, however, requires the adoption of routing solutions specifically designed for DTNs. Among the many proposals, Contact Graph Routing, designed by NASA for deep space, seems particularly appealing, as it takes advantage of the a priori knowledge of “contacts” between DTN nodes, a characteristic peculiar to both deep space and LEO environments. This paper aims to investigate the suitability of CGR in LEO satellite DTN communications, by focusing on two practical application scenarios: Earth observation and data mule. Results, obtained through a Linux testbed running ION, the DTN Bundle protocol and CGR implementation developed by NASA, highlight the advantages of CGR when applied to LEO satellite communications.
Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration: results of a single treatment in a phase 1 and 2 study.

OBJECTIVE To evaluate the safety and short-term visual and fluorescein angiographic effects of a single photodynamic therapy treatment with verteporfin with the use of different dosage regimens in patients with choroidal neovascularization (CNV) from age-related macular degeneration. DESIGN Nonrandomized, multicenter, open-label, clinical trial using 5 dosage regimens. SETTING Four ophthalmic centers in North America and Europe providing retinal care. PARTICIPANTS Patients with subfoveal CNV caused by age-related macular degeneration. METHODS Standardized protocol refraction, visual acuity testing, ophthalmic examination, color photographs, and fluorescein angiograms were used to evaluate the effects of a single treatment of photodynamic therapy with verteporfin. Follow-up was planned through 3 months in 97 patients and for less than 3 months in 31 other patients. RESULTS The mean visual acuity change (and range of change) from baseline at the follow-up examination at week 12 after a single treatment with regimens 1 through 5 was -0.2 (-3 to +2), -0.9 (-9 to +5), -1.6 (-9 to +2), +0.4 (-8 to +7), and +0.1 (-8 to +9) lines, respectively. Only the highest light dose (150 J/cm2) in regimens 2 and 3, which produced angiographic nonperfusion of neurosensory retinal vessels, caused marked vision loss. Some cessation of fluorescein leakage from CNV was achieved without loss of vision when the light dose used was less than 150 J/cm2. Systemic adverse events were rare. Cessation of fluorescein leakage from CNV was noted in all regimens by 1 week after photodynamic therapy. Fluorescein leakage from at least a portion of the CNV reappeared by 4 to 12 weeks after treatment in almost all cases. Progression of classic CNV beyond the area of CNV identified before treatment was noted in 42 (51%) of the 83 eyes with classic CNV followed up for 3 months after a single treatment. Eyes in which the area of any CNV leakage at 12 weeks was less than at baseline had a significantly better visual acuity outcome (+0.8 line) than eyes in which CNV leakage progressed (-0.8 line). CONCLUSIONS Photodynamic therapy with verteporfin achieved short-term cessation of fluorescein leakage from CNV without loss of vision or growth of classic CNV in some patients with age-related macular degeneration. Except for nonperfusion of neurosensory retinal vessels at a light dose of 150 J/cm2, no other adverse events were of concern. Randomized clinical trials to investigate whether this new modality can preserve vision in patients with CNV secondary to age-related macular degeneration are justified.
Expression of Tau40 Induces Activation of Cultured Rat Microglial Cells

Accumulation of microtubule-associated protein tau has been observed in the brain of aging and tauopathies. Tau was observed in microglia, but its role is not illustrated. By immunofluorescence staining and the fractal dimension value assay in the present study, we observed that microglia were activated in the brains of rats and mice during aging, simultaneously, the immunoreactivities of total tau and the phosphorylated tau were significantly enhanced in the activated microglia. Furtherly by transient transfection of tau40 (human 2N/4R tau) into the cultured rat microglia, we demonstrated that expression of tau40 increased the level of Iba1, indicating activation of microglia. Moreover, expression of tau40 significantly enhanced the membranous localization of the phosphorylated tau at Ser396 in microglia possibly by a mechanism involving protein phosphatase 2A, extracellular signal-regulated kinase and glycogen synthase kinase-3β. It was also found that expression of tau40 promoted microglial migration and phagocytosis, but not proliferation. And we observed increased secretion of several cytokines, including interleukin (IL)-1β, IL-6, IL-10, tumor necrosis factor-α and nitric oxide after the expression of tau40. These data suggest a novel role of human 2N/4R tau in microglial activation.
‘It Never Struck Me as Female’: Investigating Men's Entry into Female-dominated Occupations

Whilst occupational segregation by sex remains the most pervasive aspect of the labour market, some men cross gender boundaries to work in female-dominated jobs. This article explores how men who do ‘women's work’ articulate reasons for moving into such jobs. Drawing on testimonies from a purposive sample of ten British men working in non-traditional jobs, we present personal testimonies and insights that challenge existing accounts of why men enter female-dominated work places. Following Bradley, four explanations are suggested for why these men opted to do non-traditional work. They are: labour market changes; role models; possibility of different masculinities; and career ambition. We argue that existing explanations are simplistic and unable to make sense of the contingent aspects of working life that account for why men choose to pursue jobs currently dominated by women.
A Forensic Taxonomy of SCADA Systems and Approach to Incident Response

SCADA systems that monitor and control Critical National Infrastructure (CNI) are increasingly becoming the target of advanced cyber-attacks since their convergence with TCP/IP and other networks for efficient controlling. When a SCADA incident occurs the consequences can be catastrophic having an impact on the environment, economy and human life and therefore it is essential for a forensic investigation to take place. SCADA system forensics is an essential process within the cyber-security lifecycle that not only helps to identify the cause of an incident and those responsible but to help develop and design more secure systems of the future. This paper provides an overall forensic taxonomy of the SCADA system incident response model. It discusses the development of forensic readiness within SCADA system investigations, including the challenges faced by the SCADA forensic investigator and suggests ways in which the process may be improved.
Failure of self-control

Medicago truncatula and Sinorhizobium meliloti form a symbiotic association resulting in the formation of nitrogen-fixing nodules. In this organ, symbiotic cells contain large numbers of bacteroids. Remarkably, this chronic infection does not trigger visible defense reactions. Despite the importance of this phenomenon for potential transfer of the symbiotic capacity to non-legume plants, the molecular mechanisms underlying this tolerance are not understood. We have characterized the dnf2 M. truncatula mutant blocked in the symbiotic process after bacterial infection of the symbiotic cells. Nodules formed by the mutant contain only few layers of infected cells. Furthermore, they exhibit defense-like reactions which clearly contrast with premature senescence frequently observed during inefficient symbioses. This atypical phenotype raises DNF2 as an exciting starting point to investigate the molecular basis of symbiotic repression of plant defenses.
Sampling-based A* algorithm for robot path-planning

This paper presents a generalization of the classic A* algorithm to the domain of sampling-based motion planning. The root assumptions of the A* algorithm are examined and reformulated in a manner that enables a direct use of the search strategy as the driving force behind the generation of new samples in a motion graph. Formal analysis is presented to show probabilistic completeness and convergence of the method. This leads to a highly exploitative method which does not sacrifice entropy. Many improvements are presented to this versatile method, most notably, an optimal connection strategy, a bias towards the goal region via an Anytime A* heuristic, and balancing of exploration and exploitation on a simulated annealing schedule. Empirical results are presented to assess the proposed method both qualitatively and quantitatively in the context of high-dimensional planning problems. The potential of the proposed methods is apparent, both in terms of reliability and quality of solutions found.