Miracle-dz/UniFAR-FTUs huggingface dataset:
The ATESP radio survey - II. The source catalogue

This paper is part of a series reporting the results of the Australia Telescope ESO Slice Project (ATESP) radio survey obtained at 1400 MHz with the Australia Telescope Compact Array (ATCA) over the region covered by the ESO Slice Project (ESP) galaxy redshift survey. The survey consists of 16 radio mosaics with resolution and uniform sensitivity ( noise level ~79 μ Jy) over the whole area of the ESP redshift survey ( sq. degrees at ). Here we present the catalogue derived from the ATESP survey. We detected 2960 distinct radio sources down to a flux density limit of mJy (), 1402 being sub-mJy sources. We describe in detail the procedure followed for the source extraction and parameterization. The internal accuracy of the source parameters was tested with Monte Carlo simulations and possible systematic effects (e.g. bandwidth smearing) have been quantified.
Health information need and seeking behavior of patients in developing countries' context; an Iranian experience

Background and objective: Consumer Health Information (CHI) and Information Therapy (Ix) services for patients are increasingly becoming important priorities in healthcare policies around the globe. To establish, encourage and support a successful Information Therapy service in a developing country, it is essential to identify the preferences of patients, their information needs and attitudes toward CHI and Ix. This study aims to discover the attitudes of patients receiving health information in general and information prescription in particular in Iran as a developing nation. It answers the following questions: What are the patients' most essential information needs? Which channels do they choose to receive information prescription or health information from? Where do they seek health information from? How do they prefer to receive their information prescription? Methodology: An exploratory survey with an open interview and structured questionnaire was employed to gather data from patients of educational hospitals and clinics in Tabriz, Iran. Tabriz's facilities were selected for research because they admit patients from neighborhood provinces, due to the city's central location. Also, Tabriz's example of diverse dialects and literacy levels mimics a developing nation. This ensures that study findings would be transferable to other developing countries, especially one similar to Iran. Result: Receiving reliable health information and information prescription is remarkably demanded by the majority of the surveyed patients. Patients' information need is generally related to basic issues of health. The level of literacy impacts neither the demand for health information nor the patients' preferred channel to receive CHI and information prescription (P600.001). Conclusion: A localized approach, considering the socioeconomic and cultural aspects of a developing country like Iran and its limitation in using applications of information and communication technology, would make the Information Therapy and Consumer Health Information Services successful. Also, a localized approach would support the improvement in healthcare outcomes as well as health literacy.
The potential and limits of lay post-editing in an online community

This paper aims at exploring the potential of a lay community as post-editors. It focusses on 15 members of an online technology support forum, native speakers of the target language (TL) and some knowledge of the source language (SL) translating content that was machine translated from English into German specific to their own domain. It presents the most predominant errors remaining in the post-edited output and the impact of these on the quality of the post-edited output as measured by domain specialists evaluating adequacy and fluency. This paper further explores examples of these errors and possible solutions to reducing the occurrence of these and maximising the community’s potential. The targeted post-editing quality was “‘good enough”, as determined in the postediting guidelines. The PE results demonstrate that there is still room for improvement in terms of quality.
The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells

We previously showed that tumor-derived heregulin, a ligand for HER3, is associated with both de novo and acquired resistance to cetuximab. We have now examined whether patritumab, a novel neutralizing monoclonal antibody to HER3, is able to overcome such resistance. Human colorectal cancer (DiFi) cells that are highly sensitive to cetuximab were engineered to stably express heregulin by retroviral infection, and the effects of cetuximab and patritumab on the resulting DiFi-HRG cells were examined. DiFi-HRG cells released substantial amounts of heregulin and showed resistance to cetuximab. Cetuximab alone inhibited EGFR and ERK phosphorylation in DiFi-HRG cells, but it had no effect on the phosphorylation of HER2, HER3, or AKT, suggesting that sustained AKT activation by HER2 and HER3 underlies cetuximab resistance in these cells. In contrast, patritumab in combination with cetuximab markedly inhibited the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. The combination therapy also inhibited the growth of DiFi-HRG tumor xenografts in nude mice to a greater extent than did treatment with either drug alone. Activation of HER2-HER3 signaling associated with the operation of a heregulin autocrine loop confers resistance to cetuximab, and patritumab is able to restore cetuximab sensitivity through inhibition of heregulin-induced HER3 activation.
The G dwarf problem. Analysis of a new data set

The G dwarf metallicity distribution of a mass limited sample of stars within 40 pc and south of δ = −26◦ and for which Str̈omgrenuvby andHβ photometry is available is studied. Special care is taken to ensure that the sample consists of stars with a main sequence lifetime longer than the age of the Galactic disk. Furthermore, binary stars, subgiants, active stars, etc. are removed to ensure that the sample is as clean as possible. The sample was limited to the mass interval 0.7 − 1.0M using masses determined by interpolation between theoretical evolutionary tracks. A mass interval was used as opposed to a color interval, as it is more directly comparable with theoretical models. The final sample contains 253 stars. Even though the sample shows a remarkably small low metallicity tail a new scale height weighting method was developed, and used. The resulting G dwarf distribution cannot be reconciled with the simple model for chemical evolution, in fact this dataset shows that the G dwarf problem is even larger than earlier results indicate.
Competitive binding of transcription factors drives Mendelian dominance in regulatory genetic pathways

We report a new mechanism for allelic dominance in regulatory genetic interactions that we call binding dominance. We investigated a biophysical model of gene regulation, where the fractional occupancy of a transcription factor (TF) on the cis-regulated promoter site it binds to is determined by binding energy (-{\Delta}G) and TF dosage. Transcription and gene expression proceed when the TF is bound to the promoter. In diploids, individuals may be heterozygous at the cis-site, at the TF's coding region, or at the TF's own promoter, which determines allele-specific dosage. We find that when the TF's coding region is heterozygous, TF alleles compete for occupancy at the cis sites and the tighter-binding TF is dominant in proportion to the difference in binding strength. When the TF's own promoter is heterozygous, the TF produced at the higher dosage is also dominant. Cis-site heterozygotes have additive expression and therefore codominant phenotypes. Binding dominance propagates to affect the expression of downstream loci and it is sensitive in both magnitude and direction to genetic background, but its detectability often attenuates. While binding dominance is inevitable at the molecular level, it is difficult to detect in the phenotype under some biophysical conditions, more so when TF dosage is high and allele-specific binding affinities are similar. A body of empirical research on the biophysics of TF binding demonstrates the plausibility of this mechanism of dominance, but studies of gene expression under competitive binding in heterozygotes in a diversity of genetic backgrounds are needed.
Wavelet time-scale dependencies for signal and image compression

In this paper, an evolution law through scales for modulus maxima of the wavelet transform of a signal is proposed. It corresponds to an atomic approximation of wavelet detail bands. Although this result is very general and useful for various fields of image processing, we focus on its application to signal and image compression. We propose a simple trick for taking advantage from the law without directly solving its corresponding partial differential equation. Preliminary experimental results show that the proposed approach outperforms available compression techniques.
Genetic and Environmental Inﬂuences on Smoking Behavior across Adolescence and Young Adulthood in the Virginia Twin Study of Adolescent Behavioral Development and the Transitions to Substance Abuse Follow-Up

Little is known regarding the underlying relationship between smoking initiation and current quantity smoked during adolescence into young adulthood. It is possible that the inﬂuences of genetic and environmental factors on this relationship vary across sex and age. To investigate this further, the current study applied a common causal contingency model to data from a Virginia-based twin study to determine: (1) if the same genetic and environmental factors are contributing to smoking initiation and current quantity smoked; (2) whether the magnitude of genetic and environmental factor contributions are the same across adolescence and young adulthood; and (3) if qualitative and quantitative differences in the sources of variance between males and females exist. Study results found no qualitative or quantitative sex differences in the relationship between smoking initiation and current quantity smoked, though relative contributions of genetic and environmental factors changed across adolescence and young adulthood. More speciﬁcally, smoking initiation and current quantity smoked remain separate constructs until young adulthood, when liabilities are correlated. Smoking initiation is explained by genetic, shared, and unique environmental factors in early adolescence and by genetic and unique environmental factors in young adulthood; while current quantity smoked is explained by shared environmental and unique environmental factors until young adulthood, when genetic and unique environmental factors play a larger role.
Signaling Potential Adverse Drug Reactions from Administrative Health Databases

The work is motivated by real-world applications of detecting Adverse Drug Reactions (ADRs) from administrative health databases. ADRs are a leading cause of hospitalization and death worldwide. Almost all current postmarket ADR signaling techniques are based on spontaneous ADR case reports, which suffer from serious underreporting and latency. However, administrative health data are widely and routinely collected. They, especially linked together, would contain evidence of all ADRs. To signal unexpected and infrequent patterns characteristic of ADRs, we propose a domain-driven knowledge representation Unexpected Temporal Association Rule (UTAR), its interestingness measure, unexlev, and a mining algorithm MUTARA (Mining UTARs given the Antecedent). We then establish an improved algorithm, HUNT, for highlighting infrequent and unexpected patterns by comparing their ranks based on unexlev with those based on traditional leverage. Various experimental results on real-world data substantiate that both MUTARA and HUNT can signal suspected ADRs while traditional association mining techniques cannot. HUNT can reliably shortlist statistically significantly more ADRs than MUTARA (p=0.00078). HUNT, e.g., not only shortlists the drug alendronate associated with esophagitis as MUTARA does, but also shortlists alendronate with diarrhoea and vomiting for older (age ¿ 60) females. We also discuss signaling ADRs systematically by using HUNT.
Donor Characteristics of College of Education Alumni: Examining Undergraduate Involvement.

This study examlned alumni givillg as related to undergraduate involvement, student housing, academic success, and satisfaction with the education received. Two 'tundred alumni donors from Southern Illinois University at Carbondale's College of Education were surveyed, witi a 70% response rate. ihe study found that alumni donors had not been as involved in extra-curricular activities as non-donors and that on-campus residence halls and communir:, rental units had been the most common housing arrangements, though an unexpectedly high percent of respondents indicated they had lived with their parerts or at home and commuted. The study also revealed that alumni donors reported average to above average academic success as undergraduates and were highly satisfied with the education received. Overall, the two factors clearly related to giving were academic achievement and satisfaction with education received. Includes 50 refererces. (DB) *****************************P****************x*t********************** Reproductions supplied by EDRS are the best that can be made * from the original document * ****************************************************,. ****************** Donor Characteristics of College of Education Alumni: Examining Undergraduate Involvement Michael T. Miller, MSEd Doctoral Research Assistant Department of Vocational and Adult Education University of Nebraska-Lincoln Lincoln, Nebraska 68588 Arthur L. Casebeer, EdD
Perfectionism, Irrational Beliefs, Need for Social Approval and Gender as Predictors of Parent Exam Anxiety

Bu calismanin amaci ebeveyn sinav kaygisinin yordayicilari olarak sosyal onay ihtiyaci, akilci olmayan inanclar, mukemmeliyetcilik ve cinsiyetin rolunu incelemektir. Arastirmanin calisma grubunu Orta Karadeniz'de yer alan bir il merkezindeki 113 (%63.48) kadin ve 65 (%36.52) erkek olmak uzere toplam 178 ogrenci velisi olusturmaktadir. Arastirmaya katilanlarin yas ortalamasi 42.28, Ss= 5.90’dur. Arastirmada veri toplama araclari olarak, Kisisel Bilgi Formu, Sosyal Onay Ihtiyaci Olcegi, Akilci Olmayan Inanclar Olcegi, Ebeveyn Sinav Kaygisi Olcegi ve APS Mukemmeliyetcilik Olcegi kullanilmistir. Verilerin analizinde degiskenler arasindaki iliskilerin incelenmesi icin icin Pearson Momentler Carpimi Korelasyon Katsayisi ve bagimsiz degiskenlerin bagimli degiskenleri yordama gucunu belirlemek icin Coklu Regresyon Analizi kullanilmistir. Arastirma sonucunda olumlu mukemmeliyetcilik ve sosyal onay ebeveyn sinav kaygisi ile anlamli olarak iliskili olsa da regresyon modelindeki katkilari anlamli bulunmamistir. Olumsuz mukemmeliyetcilik, cinsiyet ve akilci olmayan inanclarin hep birlikte ebeveyn sinav kaygisinin yuzde 26'sini acikladigi bulunmustur. Modele sirasiyla, mukemmeliyetciligin daha sonra cinsiyetin ve son olarak akilci olmayan inanclarin katki sagladigi ortaya cikmistir.
The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj‐1 have distinct roles in recognition of a non‐native protein and protein refolding.

The properties of molecular chaperones in protein‐assisted refolding were examined in vitro using recombinant human cytosolic chaperones hsp90, hsc70, hsp70 and hdj‐1, and unfolded beta‐galactosidase as the substrate. In the presence of hsp70 (hsc70), hdj‐1 and either ATP or ADP, denatured beta‐galactosidase refolds and forms enzymatically active tetramers. Interactions between hsp90 and non‐native beta‐galactosidase neither lead to refolding nor stimulate hsp70‐ and hdj‐1‐dependent refolding. However, hsp90 in the absence of nucleotide can maintain the non‐native substrate in a ‘folding‐competent’ state which, upon addition of hsp70, hdj‐1 and nucleotide, leads to refolding. The refolding activity of hsp70 and hdj‐1 is effective across a broad range of temperatures from 22 degrees C to 41 degrees C, yet at extremely low (4 degrees C) or high (>41 degrees C) temperatures refolding activity is reversibly inhibited. These results reveal two distinct features of chaperone activity in which a non‐native substrate can be either maintained in a stable folding‐competent state or refolded directly to the native state; first, that the refolding activity itself is temperature sensitive and second, that hsp90, hsp70 (hsc70) and hdj‐1 each have distinct roles in these processes.
Understanding the Relationship Between Job Insecurity and Performance: Hindrance or Challenge Effect?

This study aims to propose a theoretical model that explains the psychological processes underlying the job insecurity–performance relationship. To accomplish this goal, we draw on a two-dimensional stressor framework. Job insecurity may undermine performance through a hindrance effect, because it causes strain reactions and withdrawal behaviors. In contrast, it can trigger productive behaviors as a form of job preservation strategy, when reacting actively. These competing predictions are integrated in the same structural equation modeling by testing the negative indirect effect of job insecurity on task and contextual performance, mediated by job satisfaction and affective commitment. The positive challenge effect is examined by testing the remaining direct path to performance. To provide convergence of evidence, two studies were conducted with the purpose to replicate patterns and findings across different measures and samples. The results provide support only for negative and passive reactions to job insecurity, leading to lower performance.
AtRabF2b (Ara7) acts on the vacuolar trafficking pathway in tobacco leaf epidermal cells

Rab GTPases are universal key regulators of intracellular secretory trafficking events. In particular, Rab 5 homologues have been implicated in endocytic events and in the vacuolar pathway. In this study, we investigate the location and function of a member of this family, AtRabF2b (Ara7) in tobacco (Nicotiana tabacum) leaf epidermal cells using a live cell imaging approach. Fluorescent-tagged AtRabF2b[wt] localized to the prevacuolar compartment and Golgi apparatus, as determined by coexpression studies with fluorescent markers for these compartments. Mutations that impair AtRabF2b function also alter the subcellular location of the GTPase. In addition, coexpression studies of the protein with the vacuole-targeted aleurain-green fluorescent protein (GFP) and rescue experiments with wild-type AtRabF2b indicate that the dominant-negative mutant of AtRabF2b causes the vacuolar marker to be secreted to the apoplast. Our results indicate a clear role of AtRabF2b in the vacuolar trafficking pathway.
Inertial effects in three-dimensional spinodal decomposition of a symmetric binary fluid mixture: a lattice Boltzmann study

The late-stage demixing following spinodal decomposition of a three-dimensional symmetric binary fluid mixture is studied numerically, using a thermodynamically consistent lattice Boltzmann method. We combine results from simulations with different numerical parameters to obtain an unprecedented range of length and time scales when expressed in reduced physical units. (These are the length and time units derived from fluid density, viscosity, and interfacial tension.) Using eight large (2563) runs, the resulting composite graph of reduced domain size l against reduced time t covers 1 [lsim ] l [lsim ] 105, 10 [lsim ] t [lsim ] 108. Our data are consistent with the dynamical scaling hypothesis that l(t) is a universal scaling curve. We give the first detailed statistical analysis of fluid motion, rather than just domain evolution, in simulations of this kind, and introduce scaling plots for several quantities derived from the fluid velocity and velocity gradient fields. Using the conventional definition of Reynolds number for this problem, Reϕ = ldl/dt, we attain values approaching 350. At Reϕ [gsim ] 100 (which requires t [gsim ] 106) we find clear evidence of Furukawa's inertial scaling (l ∼ t2/3), although the crossover from the viscous regime (l ∼ t) is both broad and late (102 [lsim ] t [lsim ] 106). Though it cannot be ruled out, we find no indication that Reϕ is self-limiting (l ∼ t1/2) at late times, as recently proposed by Grant & Elder. Detailed study of the velocity fields confirms that, for our most inertial runs, the RMS ratio of nonlinear to viscous terms in the Navier–Stokes equation, R2, is of order 10, with the fluid mixture showing incipient turbulent characteristics. However, we cannot go far enough into the inertial regime to obtain a clear length separation of domain size, Taylor microscale, and Kolmogorov scale, as would be needed to test a recent ‘extended’ scaling theory of Kendon (in which R2 is self-limiting but Reϕ not). Obtaining our results has required careful steering of several numerical control parameters so as to maintain adequate algorithmic stability, efficiency and isotropy, while eliminating unwanted residual diffusion. (We argue that the latter affects some studies in the literature which report l ∼ t2/3 for t [lsim ] 104.) We analyse the various sources of error and find them just within acceptable levels (a few percent each) in most of our datasets. To bring these under significantly better control, or to go much further into the inertial regime, would require much larger computational resources and/or a breakthrough in algorithm design.
Pre-stimulation of CD81 expression by resting B cells increases proliferation following EBV infection, but the overexpression of CD81 induces the apoptosis of EBV-transformed B cells

Hepatitis C virus (HCV) E2 protein binds to CD81, which is a component of the B cell co-stimulatory complex. The E2-CD81 interaction leads to B cell proliferation, protein tyrosine phosphorylation and to the hypermutation of immunoglobulin genes. Epidemiological studies have reported a high prevalence of B cell non-Hodgkin lymphoma (NHL) in HCV-positive patients, suggesting a potential association between HCV and Epstein-Barr virus (EBV) in the genesis of B lymphocyte proliferative disorders. In the present study, in order to investigate the association between EBV and HCV in B cells, we created an in vitro EBV-induced B cell transformation model. CD81 was gradually overexpressed during transformation by EBV. B cells isolated from HCV-positive patients grew more rapidly and clumped together earlier than B cells isolated from healthy donors following EBV infection. Pre-stimulation of CD81 expressed by resting B cells with anti-CD81 monoclonal antibody (mAb) or HCV E2 accelerated the generation of lymphoblastoid cell lines (LCLs) by EBV infection. These cells proliferated prominently through the early expression of interleukin-10 and intracellular latent membrane protein (LMP)-l. By contrast, the overexpression of CD81 on EBV-transformed B cells by anti-CD81 mAb or HCV E2 protein induced apoptosis through reactive oxygen species (ROS)-mediated mitochondrial dysfunction. These results suggest that the engagement of CD81 expressed by B cells has differential effects on B cell fate (proliferation or apoptosis) according to EBV infection and the expression level of CD81.