Miracle-dz/UniFAR-FTUs huggingface dataset:
IgG4-related Sclerosing Mesenteritis in a 7-year-old Saudi Girl

Sclerosing mesenteritis (SM) is a rare, benign inflammatory disorder of unknown etiology, affecting the membranes of the digestive tract that involves lymphoplasmacytic inflammation, fat necrosis, and fibrosis of the mesentery. We report a child patient with a history of recurrent abdominal pain and fever who was found to have an intra-abdominal mass suspicious for malignancy. A tissue biopsy revealed the diagnosis of SM associated with IgG4-related systemic disease. The patient is currently maintained on 5 mg prednisone daily and no recurrence of symptoms was noted during the 24-month follow-up period. We emphasize, therefore, that SM can present clinical challenges and the presence of SM should cue clinicians to search for other coexisting autoimmune disorders that can have various outcomes.
Adaptation of hidden Markov models using maximum model distance algorithm

This paper presents a new approach that uses the maximum model distance (MMD) method for the adaptation of hidden Markov models (HMMs). This method has the same framework as it is used for constructing speech recognizers with abundant data, and work effectively with any amount of adaptation data. All parameters of the HMMs with or without the adaptation data could be adapted. If the adaptation data is sufficient, then the adapted models will gradually become a speaker-dependent one. Both the dialect and the speaker adaptation experiments were conducted to investigate the effectiveness of the proposed algorithm. In the speaker adaptation experiments, up to 65.55% phoneme error reduction was achieved, and the MMD could reduce the phoneme error by 16.91% even only one adaptation utterance is available.
Watermarking Relational Databases

Uptil now most of the work is done on image, video, audio.but today the Database watermarking becomes the research topic because of the increasing the use of relational database systems. Which deals with the legal issue of copyright protection of database systems. Watermarking is an information hiding technique which is used to embed a mark within some host content. In this paper,we have focused on the review of four relational database watermarking techniques proposed by researchers [R.Agarwal & Jerry Kiernan, ZHU Qin, Brijesh B. Mehta, A.Odeh and A. Al-Haj].
Serotype Sensitivity of a Lateral Flow Immunoassay for Cryptococcal Antigen

ABSTRACT To meet the needs of a global community, an immunoassay for cryptococcal antigen (CrAg) must have high sensitivity for CrAg of all major serotypes. A new immunoassay for CrAg in lateral flow format was evaluated and found to have a high sensitivity for detection of serotypes A, B, C, and D.
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting

Macrophage migration inhibitory factor (MIF) is a mediator of host immunity and functions as a high, upstream activator of cells within the innate and the adaptive immunological systems. Recent studies have suggested a potentially broader role for MIF in growth regulation because of its ability to antagonize p53-mediated gene activation and apoptosis. To better understand MIF's activity in growth control, we generated and characterized a strain of MIF-knockout (MIF-KO) mice in the inbred, C57BL/6 background. Embryonic fibroblasts from MIF-KO mice exhibit p53-dependent growth alterations, increased p53 transcriptional activity, and resistance to ras-mediated transformation. Concurrent deletion of the p53 gene in vivo reversed the observed phenotype of cells deficient in MIF. In vivo studies showed that fibrosarcomas induced by the carcinogen benzo[α]pyrene are smaller in size and have a lower mitotic index in MIF-KO mice relative to their WT counterparts. The data provide direct genetic evidence for a functional link between MIF and the p53 tumor suppressor and indicate an important and previously unappreciated role for MIF in carcinogenesis.
Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88-Dependent and -Independent Signaling and Is Reciprocally Modulated by Liver X Receptor Activation1

Chlamydia pneumoniae is detected by macrophages and other APCs via TLRs and can exacerbate developing atherosclerotic lesions, but how that occurs is not known. Liver X receptors (LXRs) centrally control reverse cholesterol transport, but also negatively modulate TLR-mediated inflammatory pathways. We isolated peritoneal macrophages from wild-type, TLR2, TLR3, TLR4, TLR2/4, MyD88, TRIF, MyD88/TRIF, and IFN regulatory factor 3 (IRF3) KO mice, treated them with live or UV-killed C. pneumoniae in the presence or absence of oxidized LDL, then measured foam cell formation. In some experiments, the synthetic LXR agonist GW3965 was added to macrophages infected with C. pneumoniae in the presence of oxidized LDL. Both live and UV-killed C. pneumoniae induced IRF3 activation and promoted foam cell formation in wild-type macrophages, whereas the genetic absence of TLR2, TLR4, MyD88, TRIF, or IRF3, but not TLR3, significantly reduced foam cell formation. C. pneumoniae-induced foam cell formation was significantly reduced by the LXR agonist GW3965, which in turn inhibited C. pneumoniae-induced IRF3 activation, suggesting a bidirectional cross-talk. We conclude that C. pneumoniae facilitates foam cell formation via activation of both MyD88-dependent and MyD88-independent (i.e., TRIF-dependent and IRF3-dependent) pathways downstream of TLR2 and TLR4 signaling and that TLR3 is not involved in this process. This mechanism could at least partly explain why infection with C. pneumoniae accelerates the development of atherosclerotic plaque and lends support to the proposal that LXR agonists might prove clinically useful in suppressing atherogenesis.
Network-wide BGP route prediction for traffic engineering

The Internet consists of about 13,000 Autonomous Systems (AS's) that exchange routing information using the Border Gateway Protocol (BGP). The operators of each AS must have control over the flow of traffic through their network and between neighboring AS's. However, BGP is a complicated, policy-based protocol that does not include any direct support for traffic engineering. In previous work, we have demonstrated that network operators can adapt the flow of traffic in an efficient and predictable fashion through careful adjustments to the BGP policies running on their edge routers. Nevertheless, many details of the BGP protocol and decision process make predicting the effects of these policy changes difficult. In this paper, we describe a tool that predicts traffic flow at network exit points based on the network topology, the import policy associated with each BGP session, and the routing advertisements received from neighboring AS's. We present a linear-time algorithm that computes a network-wide view of the best BGP routes for each destination prefix given a static snapshot of the network state, without simulating the complex details of BGP message passing. We describe how to construct this snapshot using the BGP routing tables and router configuration files available from operational routers. We verify the accuracy of our algorithm by applying our tool to routing and configuration data from AT&T's commercial IP network. Our route prediction techniques help support the operation of large IP backbone networks, where interdomain routing is an important aspect of traffic engineering.
O-GlcNAcylation and Inflammation: A Vast Territory to Explore

O-GlcNAcylation is a reversible post-translational modification that regulates the activities of cytosolic and nuclear proteins according to glucose availability. This modification appears to participate in several hyperglycemia-associated complications. An important feature of metabolic diseases such as diabetes and obesity is the presence of a low-grade chronic inflammation that causes numerous complications. Hyperglycemia associated with the metabolic syndrome is known to promote inflammatory processes through different mechanisms including oxidative stress and abnormally elevated protein O-GlcNAcylation. However, the role of O-GlcNAcylation on inflammation remains contradictory. O-GlcNAcylation associated with hyperglycemia has been shown to increase nuclear factor κB (NFκB) transcriptional activity through different mechanisms. This could contribute in inflammation-associated diabetic complications. However, in other conditions such as acute vascular injury, O-linked N-acetyl glucosamine (O-GlcNAc) also exerts anti-inflammatory effects via inhibition of the NFκB pathway, suggesting a complex regulation of inflammation by O-GlcNAc. Moreover, whereas macrophages and monocytes exposed to high glucose for a long-term period developed a pro-inflammatory phenotype, the impact of O-GlcNAcylation in these cells remains unclear. A future challenge will be to clearly establish the role of O-GlcNAcylation in pro- and anti-inflammatory functions in macrophages.
An Improved Measurement Model for IPv6 Network

A novel time stamp extension header used to record the packet through the router’s time for IPv6 network is designed. Based on this type of packet a new link utilization measurement method is promoted. Source sends probe packets initiative, the router time is recorded in the packets hop by hop. Through the statistical processing, eliminate the packet processing delay, propagation delay, transmission delay and the router clock skew, then the queuing delay of each probing packet is obtained. Using the Link Status Smoothed Algorithm, the queuing delay transforms into the sequence of the link status, finally gets the link utilization. This approach is verified through simulations.
Trust and Reciprocity: Are Effort and Money Equivalent?

Trust and reciprocity facilitate cooperation and are relevant to virtually all human interactions. They are typically studied using trust games: one subject gives (entrusts) money to another subject, which may return some of the proceeds (reciprocate). Currently, however, it is unclear whether trust and reciprocity in monetary transactions are similar in other settings, such as physical effort. Trust and reciprocity of physical effort are important as many everyday decisions imply an exchange of physical effort, and such exchange is central to labor relations. Here we studied a trust game based on physical effort and compared the results with those of a computationally equivalent monetary trust game. We found no significant difference between effort and money conditions in both the amount trusted and the quantity reciprocated. Moreover, there is a high positive correlation in subjects' behavior across conditions. This suggests that trust and reciprocity may be character traits: subjects that are trustful/trustworthy in monetary settings behave similarly during exchanges of physical effort. Our results validate the use of trust games to study exchanges in physical effort and to characterize inter-subject differences in trust and reciprocity, and also suggest a new behavioral paradigm to study these differences.
Generalized theory of helicon waves. II. Excitation and absorption

Helicon waves in a plasma confined by a cylinder are treated. The undamped normal modes of the helicon (H) and Trivelpiece–Gould (TG) waves have distinctly different wave patterns at high magnetic fields but at low fields have similar patterns and therefore interact strongly. Damping of these modes, their excitation by antennas, and the rf plasma absorption efficiency are considered. Nonuniform plasmas are treated by solving a fourth-order ordinary differential equation numerically. A significant difference between this and earlier codes which divide the plasma into uniform shells is made clear. Excitation of the weakly damped H wave, followed by conversion to the strongly damped TG wave which leads to high helicon discharge efficiency, is examined for realistic density profiles. A reason for the greater heating efficiency of the m=+1 vs the m=−1 mode for axially peaked profiles is provided.
Negative Effects of Bytecode Instrumentation on Java Source Code Coverage

Code coverage measurement is an important element in white-box testing, both in industrial practice and academic research. Other related areas are highly dependent on code coverage as well, including test case generation, test prioritization, fault localization, and others. Inaccuracies of a code coverage tool sometimes do not matter that much but in certain situations they can lead to serious confusion. For Java, the prevalent approach to code coverage measurement is to use bytecode instrumentation due to its various benefits over source code instrumentation. However, if the results are to be mapped back to source code this may lead to inaccuracies due to the differences between the two program representations. In this paper, we systematically investigate the amount of differences in the results of these two Java code coverage approaches, enumerate the possible reasons and discuss the implications on various applications. For this purpose, we relied on two widely used tools to represent the two approaches and a set of benchmark programs from the open source domain.
Designing Virtual Audiences for Fear of Public Speaking Training - An Observation Study on Realistic Nonverbal Behavior

Virtual Reality technology offers great possibilities for Cognitive Behavioral Therapy of fear of public speaking: Clients can be exposed to virtual fear-triggering stimuli (exposure) and are able to role-play in virtual environments, training social skills to overcome their fear. Usually, prototypical audience behavior (neutral, social and anti-social) serves as stimulus in virtual training sessions, although there is significant lack of theoretical basis on typical audience behavior. The study presented deals with the design of a realistic virtual presentation scenario. An audience (consisting of n=18 men and women) in an undergraduate seminar was observed during three frontal lecture sessions. Behavior frequency of four nonverbal dimensions (eye contact, facial expression, gesture, and posture) was rated by means of a quantitative content analysis. Results show audience behavior patterns which seem to be typical in frontal lecture contexts, like friendly and neutral face expressions. Additionally, combined and even synchronized behavioral patterns between participants who sit next to each other (like turning to the neighbor and start talking) were registered. The gathered data serve as empirical design basis for a virtual audience to be used in virtual training applications that stimulate the experiences of the participants in a realistic manner, thereby improving the experienced presence in the training application.
Efficacy of remission-induction regimens for ANCA-associated vasculitis.

BACKGROUND The 18-month efficacy of a single course of rituximab as compared with conventional immunosuppression with cyclophosphamide followed by azathioprine in patients with severe (organ-threatening) antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is unknown. METHODS In a multicenter, randomized, double-blind, double-dummy, noninferiority trial, we compared rituximab (375 mg per square meter of body-surface area administered once a week for 4 weeks) followed by placebo with cyclophosphamide administered for 3 to 6 months followed by azathioprine for 12 to 15 months. The primary outcome measure was complete remission of disease by 6 months, with the remission maintained through 18 months. RESULTS A total of 197 patients were enrolled. As reported previously, 64% of the patients in the rituximab group, as compared with 53% of the patients in the cyclophosphamide-azathioprine group, had a complete remission by 6 months. At 12 and 18 months, 48% and 39%, respectively, of the patients in the rituximab group had maintained the complete remissions, as compared with 39% and 33%, respectively, in the comparison group. Rituximab met the prespecified criteria for noninferiority (P<0.001, with a noninferiority margin of 20%). There was no significant difference between the groups in any efficacy measure, including the duration of complete remission and the frequency or severity of relapses. Among the 101 patients who had relapsing disease at baseline, rituximab was superior to conventional immunosuppression at 6 months (P=0.01) and at 12 months (P=0.009) but not at 18 months (P=0.06), at which time most patients in the rituximab group had reconstituted B cells. There was no significant between-group difference in adverse events. CONCLUSIONS In patients with severe ANCA-associated vasculitis, a single course of rituximab was as effective as continuous conventional immunosuppressive therapy for the induction and maintenance of remissions over the course of 18 months. (Funded by the National Institute of Allergy and Infectious Diseases and others; RAVE ClinicalTrials.gov number, NCT00104299.)
Making Sense of Cents: An Examination of Firms that Marginally Miss or Beat Analysts Forecasts

This paper examines the performance consequences of cutting discretionary expenditures and managing accruals to exceed analyst forecasts. We show that firms that just beat analyst forecasts with low quality earnings exhibit a short-term stock price benefit relative to firms that miss forecasts with high quality earnings. This trend, however, reverses over a 3-year horizon. Additionally, firms reducing discretionary expenditures to beat forecasts have significantly greater equity issuances and insider selling in the following year, consistent with managers understanding the myopic nature of their actions. Our results confirm survey evidence suggesting managers engage in myopic behavior to beat benchmarks. THERE IS GROWING EVIDENCE that managers are willing to sacrifice economic value to meet short-run earnings objectives. For example, Graham, Harvey, and Rajagopal (2005) report that a majority of managers would forgo a project with positive net present value (NPV) if the project would cause them to fall short of the current quarter consensus forecast. When asked what actions they might take in order to meet an earnings target, approximately 80% suggest they would decrease discretionary spending, including R&D and advertising expense. This survey evidence is consistent with other research on myopic behavior and real earnings management (e.g., Baber, Fairfield, and Haggard (1991), Bhojraj and Libby (2005), Roychowdhury (2006)). Jensen (2005) attributes this behavior in part to the agency costs of overvalued equity, noting that “when numbers are manipulated to tell the market what they want to hear . and when real operating decisions that would maximize value are compromised to meet market expectations, real long-term value is being destroyed” (p. 8). In this paper, we provide evidence on the shortand long-term price and profitability ∗Sanjeev Bhojraj is from the Johnson School of Management, Cornell University. Paul Hribar is from the Tippie College of Business, University of Iowa. Marc Picconi is from the Kelley School of Business, Indiana University. John McInnis is from the McCombs School of Business, University of Texas at Austin. The authors gratefully acknowledge the insightful comments and suggestions made by Cam Harvey (the editor), an associate editor, and an anonymous referee, as well as seminar participants at Cornell University, Columbia University, Duke University, the University of Illinois, the University of Minnesota, the University of North Carolina, the University of Oklahoma, the University of Rochester, and Washington University in St. Louis. The authors thank Thomson Financial Services Inc. for providing earnings per share forecast data, available through the Institutional Brokers Estimate System (I/B/E/S). These data have been provided as part of a broad academic program to encourage earnings expectation research.
Low-complexity partitioned-spreading CDMA system with multistage MMSE reception

In this paper, we propose a low-complexity multistage filter for the partitioned-spreading CDMA (PS-CDMA). The proposed method embodies a MMSE filter that operates on the soft output of interference cancellation. Extrinsic information on the partitioned symbol is exchanged between the MMSE filter and the partitioned-spreading APP detector to improve the system performance. It is shown via variance evolution the signal-to-noise ratio of this novel technique achieves that of the single-user channel even for heavily loaded systems. It also outperforms IDMA by a fraction of dB to a few dBs, for a variety of system loads. The complexity of the proposed system is much lower that of its counterparts for conventional CDMA, which makes it a viable alternative for future 3G or beyond 3G systems
Grape-Derived Polyphenols Improve Aging-Related Endothelial Dysfunction in Rat Mesenteric Artery: Role of Oxidative Stress and the Angiotensin System

Aging is characterized by the development of an endothelial dysfunction, which affects both the nitric oxide (NO)- and the endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxations, associated with vascular oxidative stress and the activation of the angiotensin system. This study investigated whether red wine polyphenols (RWPs), antioxidants and potent stimulators of NO- and EDHF-mediated relaxations improve aging-related endothelial dysfunction, and, if so, examined the underlying mechanism. Mesenteric artery reactivity was determined in organ chambers, vascular oxidative stress by dihydroethidine and MitoSOX staining, and expression of target proteins by immunohistochemical staining. Control young rats (16 weeks) received solvent (ethanol, 3% v/v), and middle-aged rats (46 weeks) either solvent or RWPs (100 mg/kg/day) in the drinking water. The acetylcholine-induced endothelium-dependent NO component was slightly reduced whereas the EDHF component was markedly blunted in rings of middle-aged rats compared to young rats. The endothelial dysfunction was associated with oxidative stress, an upregulation of angiotensin II and AT1 receptors and a down-regulation of SKCa, IKCa, and angiotensin converting enzyme. Intake of RWPs for either one or two weeks improved the NO and the EDHF components of the relaxation, and normalized oxidative stress, the expression of SKCa, IKCa and the components of the angiotensin system. The protective effect of the 2-week RWPs treatment persisted for one and two weeks following stopping intake of RWPs. Thus, intake of RWPs caused a persistent improvement of the endothelial function, particularly the EDHF component, in middle-aged rats and this effect seems to involve the normalization of the expression of SKCa, IKCa and the angiotensin system.