Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic Analysis of Jacket Substructure for Offshore Wind Turbine Generators under Extreme Environmental Conditions

In order to develop dynamic analysis technologies regarding the design of offshore wind turbine generators (OWTGs), a special project called Offshore Code Comparison Collaboration Continuation (OC4) was conducted by IEA (International Energy Agency) in 2010. A similar project named INER-OC4 has been performed by the Institute of Nuclear Energy Research (INER) to develop the OWTG technologies of Taiwan. Since the jacket substructure will be applied to Taiwan OWTGs before 2020, the INER-OC4 project has been devoted to the design and analysis of jacket support structure. In this work, the preliminary result of INER-OC4 is presented. A simplified analysis procedure for jacket support structure has been proposed. Both of the NREL (National Renewable Energy Laboratory) 5 MW OWTG FAST model and OC4 jacket substructure model have been built and analyzed under severe design load cases (DLCs) of IEC (International Electrotechnical commission) 61400-3. Simulation results of six severe DLCs are performed in this work and the results are in agreement with the requirements of API (American Petroleum Institute) and NORSOK (Norwegian Petroleum Industry) standards.
Tracer diffusion at low temperature in kinetically constrained models

We describe the motion of a tracer in an environment given by a kinetically constrained spin model (KCSM) at equilibrium. We check convergence of its trajectory properly rescaled to a Brownian motion and positivity of the diffusion coefficient $D$ as soon as the spectral gap of the environment is positive (which coincides with the ergodicity region under general conditions). Then we study the asymptotic behavior of $D$ when the density $1-q$ of the environment goes to $1$ in two classes of KCSM. For noncooperative models, the diffusion coefficient $D$ scales like a power of $q$, with an exponent that we compute explicitly. In the case of the Fredrickson-Andersen one-spin facilitated model, this proves a prediction made in Jung, Garrahan and Chandler [Phys. Rev. E 69 (2004) 061205]. For the East model, instead we prove that the diffusion coefficient is comparable to the spectral gap, which goes to zero faster than any power of $q$. This result contradicts the prediction of physicists (Jung, Garrahan and Chandler [Phys. Rev. E 69 (2004) 061205; J. Chem. Phys. 123 (2005) 084509]), based on numerical simulations, that suggested $D\sim \operatorname {gap}^{\xi}$ with $\xi<1$.
Profiles of trauma exposure and biopsychosocial health among sex trafficking survivors: exploring differences in help-seeking attitudes and intentions

Human sex trafficking is a complex and unique phenomenon involving the commercial sexual exploitation (CSE) of persons by means of force, fraud, or coercion. The purpose of this study was to investigate unique patterns of trauma exposure and biopsychosocial health among a sample of CSE survivors. Results from a latent profile analysis with 135 adults trafficked in the United States yielded three distinct survivor sub-groups: mildly distressed, moderately distressed, and severely distressed. The mildly distressed class (18.5%) was characterized by the lowest reports of trauma exposure and an absence of clinically significant psycho-social stress symptoms. The moderately distressed class (48.89%) endorsed comparatively medial levels of trauma exposure, as well as clinically significant disturbance in six domains of psycho-social health. The severely distressed class (32.59%) reported the highest degree of trauma exposure and exhibited clinically significant symptoms of pervasive psycho-social stress across all domains assessed. To better understand variation in CSE survivors’ engagement with formal support services, this study also examined differences in help-seeking attitudes and intentions between latent classes. Results indicated that compared to those in the mildly and moderately distressed classes, severely distressed survivors endorsed significantly more unfavorable attitudes toward seeking professional help, along with no intention to seek help from any source when facing a personal or emotional crisis. Findings from this study provide a snapshot of significant heterogeneity in trauma exposure and biopsychosocial health among CSE survivors, as well as associated differences in help-seeking attitudes and intentions. The identification of distinct survivor sub-groups in these and future analyses mark an important intermediate step toward developing empirically-testable support services that are specifically designed to meet the unique needs of CSE survivors. Profiles of trauma exposure and biopsychosocial health among sex trafficking survivors: Exploring differences in help-seeking attitudes and intentions
Evaluation of Post-Harvest Organic Carbon Amendments as a Strategy to Minimize Nitrogen Losses in Cole Crop Production

Cole crops (Brassica vegetables) can pose a significant risk for N losses during the post-harvest period due to substantial amounts of readily mineralizable N in crop residues. Amending the soil with organic C has the potential to immobilize N and thereby reduce the risk for N losses. Four field trials were conducted to determine the effects of organic C amendments (OCA) on N dynamics and spring wheat (Triticum durum L.) harvest parameters proceeding early- and late-broccoli (Brassica olecerea var italica L.) systems in 2009 and 2010. The experimental controls represented the traditional grower practice of incorporated broccoli crop residue (CR-control) and the pre-plant application of N fertilizer (CRN-control) to subsequent spring wheat. Alternative practices were compared to the controls, which included broccoli crop residue removal (CR-removal), an oat (Avena sativa L.) cover crop (CC-oat), and three different OCA of wheat straw (OCA-straw), yard waste (OCA-yard), or used cooking oil (OCA-oil). The treatments, which demonstrated reduced autumn soil mineral N (SMN) concentrations after broccoli harvest, relative to the CR-control, were CR-removal, OCA-straw, and OCA-oil. Although CR-removal and OCA-straw indicated a reduced potential for autumn soil N losses in the early-broccoli system, these practices are not recommended for growers because subsequent spring wheat yield and profit margins were reduced compared to the CR- and CRN-controls. The OCA-oil reduced autumn SMN concentrations by 53 to 112 kg N ha−1 relative to the CR-control after both early- and late-broccoli harvest, suggesting a larger potential for reduced autumn soil N losses, compared to all other treatments. No detrimental effects resulted from the OCA-oil treatment on the subsequent spring yield or grain N. The OCA-oil reduced spring wheat profit margins relative to the CR-control, like the OCA-straw and CR-removal treatments, however profit margins were similar between the OCA-oil and the CRN-control. Therefore, in areas with a high risk of environmental N contamination, growers should consider the OCA-oil practice after cole crop harvest to minimize the risk of N losses.
Alcohol Use in Pregnancy and Miscarriage: A Systematic Review and Meta-Analysis.

OBJECTIVE To systematically review and critically evaluate studies reporting alcohol exposure during pregnancy and miscarriage. METHODS We searched PubMed, EMBASE, PsycINFO, and ProQuest Theses for publications from January 1970 to January 2019. We identified studies about alcohol exposure during pregnancy and miscarriage. Information about study population, alcohol exposure assessment, outcome definition, covariates, and measures of association were collected. We assessed study quality using an adapted Newcastle-Ottawa Scale. Data were abstracted by two investigators independently. We conducted a random-effects meta-analysis to calculate the association between alcohol exposure and miscarriage risk and performed subgroup analyses to determine robustness of results to study differences. For studies reporting dose-specific effects, a pooled dose-response association was estimated using generalized least squares regression with and without restricted cubic spline terms for number of drinks consumed per week. RESULTS Of 2,164 articles identified, 24 were eligible for inclusion. Meta-analysis of data from 231,808 pregnant women finds those exposed to alcohol during pregnancy have a greater risk of miscarriage compared to those who abstained (odds ratio [OR] 1.19, 95% confidence intervals [CI] 1.12, 1.28). Estimates did not vary by study design, study country, or method of alcohol ascertainment. For alcohol use of five or fewer drinks per week, each additional drink per week was associated with a six percent increase in miscarriage risk (OR 1.06, 95% CI 1.01, 1.10). Common study limitations reflect challenges inherent to this research, including difficulty recruiting participants early enough in pregnancy to observe miscarriage and collecting and quantifying information about alcohol consumption during pregnancy that accurately reflects use. CONCLUSIONS This review provides evidence that alcohol consumption during pregnancy is associated with a dose-mediated increase in miscarriage risk. Future studies evaluating change in alcohol use in pregnancy are needed to provide insight into how alcohol consumption prior to pregnancy recognition impacts risk. This article is protected by copyright. All rights reserved.
Iron Deficiency in Young Children: A Risk Marker for Early Childhood Caries

ABSTRACT Aim: Evaluate the coexistence of iron deficiency and early childhood caries. Evaluate whether iron deficiency can be considered as a risk marker for early childhood caries. Estimate the incidence of iron deficiency in children with early childhood caries. To evaluate and compare the iron status of children with and without severe early childhood caries. Materials and methods: Sixty children of age 2 to 6 years in whom blood investigations are advised by pediatricians are selected for the study and are divided into early childhood caries (ECC) and control groups according to the def index. After obtaining the informed consent from parent, blood investigations are carried out in these children for the estimation of iron status. Results: All the values depicting the iron status are found to be decreased in the clinical trial group (ECC group) and they are statistically significant. Conclusion: Iron deficiency is observed definitely in children having ECC. How to cite this article: Koppal PI, Sakri MR, Akkareddy B, Hinduja DM, Gangolli RA, Patil BC. Iron Deficiency in Young Children: A Risk Marker for Early Childhood Caries. Int J Clin Pediatr Dent 2013;6(1):1-6.
The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation

Recent work indicates that signaling events resulting from stimulation of the T cell antigen receptor (TCR) can be initiated by the CD3 complex (gamma, delta, epsilon) as well as the zeta chains of the receptor. To help characterize the signaling function of CD3 we examined its associated tyrosine kinase activity since induction of tyrosine phosphorylation is one of the earliest signaling events. Our results indicate that at least two kinases, lck and ZAP-70, contribute to the CD3-associated kinase activity. A likely target of this activity is the CD3 complex itself since we observed that TCR stimulation resulted in rapid tyrosine phosphorylation of the CD3 epsilon and delta chains. To examine the function of the CD3 epsilon chain in particular, we constructed a chimera that fused the extracellular and transmembrane domains of CD8 to the cytoplasmic domain of CD3 epsilon. This chimera demonstrated that CD3 epsilon was independently capable of associating with proteins having tyrosine kinase activity, including ZAP-70. Our results show that the kinase activity that associates with the CD3 complex has characteristics that are quite similar to the previously characterized zeta-associated kinase activity. This finding suggests that both these components of the TCR initiate signaling events using a common mechanism. However, differences in their signaling function could result from recognition of distinct substrates.
Paternal history of depression or anxiety disorder and infant–father attachment

Paternal depression and anxiety are important risk factors for a problematic parent–child relationship and subsequent child development. We explored the association between paternal history of depression and anxiety disorder and infant–father attachment security, taking into account the possible mediating roles of sensitivity and perceived family stress. In a sample of 94 infant–father dyads, a structured diagnostic interview and a questionnaire on family stress were administered during pregnancy. Paternal sensitivity was observed using the Ainsworth coding scales, and infant–father attachment was observed in the strange situation procedure during a lab visit at 14 months. Linear regression models were used to examine the association of father's lifetime depression or anxiety with the continuous scales for infant–father attachment security and disorganization. Father's history of depression or anxiety disorder was not significantly related to infant–father attachment security in the total sample. Interestingly, daughters of fathers with a history of depression or anxiety had higher scores on attachment security than daughters of fathers without this diagnosis. Perceived family stress and paternal sensitivity were not significant mediators. We discuss these unexpected findings, suggesting alternative mechanisms for how paternal vulnerability to depression or anxiety may be associated with the infant–father attachment relationship. Highlights: We examine the association between paternal history of depression and anxiety disorder and infant-father attachment security. In 94 infant-father dyads, a structured diagnostic interview was administered and infant-father attachment was observed in the Strange Situation Procedure. Daughters of fathers with a psychiatric history had higher scores on attachment security. Mechanisms of paternal vulnerability are discussed.
A Privacy-Preserving Framework for Personalized, Social Recommendations

We consider the problem of producing item recommendations that are personalized based on a user’s social network, while simultaneously preventing the disclosure of sensitive user-item preferences (e.g., product purchases, ad clicks, web browsing history, etc.). Our main contribution is a privacypreserving framework for a class of social recommendation algorithms that provides strong, formal privacy guarantees under the model of dierential privacy. Existing mechanisms for achieving dierential privacy lead to an unacceptable loss of utility when applied to the social recommendation problem. To address this, the proposed framework incorporates a clustering procedure that groups users according to the natural community structure of the social network and signicantly reduces the amount of noise required to satisfy dierential privacy. Although this reduction in noise comes at the cost of some approximation error, we show that the benets of the former signicantly outweigh the latter. We explore the privacy-utility trade-o for several dierent instantiations of the proposed framework on two real-world data sets and show that useful social recommendations can be produced without sacricing privacy. We also experimentally compare the proposed framework with several existing dierential privacy mechanisms and show that the proposed framework signicantly outperforms all of them in this setting.
Minimum-Effort Coordination Games: Stochastic Potential and Logit Equilibrium

Abstract This paper revisits the minimum-effort coordination game with a continuum of Pareto-ranked Nash equilibria. Noise is introduced via a logit probabilistic choice function. The resulting logit equilibrium distribution of decisions is unique and maximizes a stochastic potential function. In the limit as the noise vanishes, the distribution converges to an outcome that is analogous to the risk-dominant outcome for 2 × 2 games. In accordance with experimental evidence, logit equilibrium efforts decrease with increases in effort costs and the number of players, even though these parameters do not affect the Nash equilibria. Journal of Economic Literature Classification Numbers: C72, C92.
Membrane potential bistability is controlled by the hyperpolarization‐activated current IH in rat cerebellar Purkinje neurons in vitro

We investigated the role of the hyperpolarization‐activated mixed cation current, IH, in the control of spontaneous action potential firing of rat cerebellar Purkinje neurons in brain slices. Extracellular recordings revealed that the continual action potential firing of Purkinje neurons was disrupted by the pharmacological blockade of IH. Blockade of IH revealed spontaneous transitions between periods of tonic action potential firing and quiescence, without effects on the frequency or variance of action potential generation. Whole‐cell recordings revealed that blockade of IH unmasked a form of membrane potential bistability, where transitions between tonic firing and quiescent states (separated by ∼20 mV) were evoked by excitatory and inhibitory postsynaptic potentials, or by the delivery of brief (20 ms) somatic or dendritic positive and negative current pulses. The stable upper state of tonic action potential firing was maintained by the recruitment of axo‐somatic voltage‐activated sodium, but not calcium, channels. Negative modulation of IH by serotonin unmasked bistability, indicating that bistability of Purkinje neurons is likely to occur under physiological conditions. These data indicate that IH acts as a ‘safety net’, maintaining the membrane potential of Purkinje neurons within the range necessary for the generation of tonic action potential firing. Following the downregulation of IH, synaptic inhibition can generate long periods (seconds) of quiescence, the duration of which can be controlled by climbing fibre activation and by the underlying ‘tone’ of parallel fibre activity.
Structure–Biological Function Relationship Extended to Mitotic Arrest-Deficient 2-Like Protein Mad2 Native and Mutants-New Opportunity for Genetic Disorder Control

Overexpression of mitotic arrest-deficient proteins Mad1 and Mad2, two components of spindle assembly checkpoint, is a risk factor for chromosomal instability (CIN) and a trigger of many genetic disorders. Mad2 transition from inactive open (O-Mad2) to active closed (C-Mad2) conformations or Mad2 binding to specific partners (cell-division cycle protein 20 (Cdc20) or Mad1) were targets of previous pharmacogenomics studies. Here, Mad2 binding to Cdc20 and the interconversion rate from open to closed Mad2 were predicted and the molecular features with a critical contribution to these processes were determined by extending the quantitative structure-activity relationship (QSAR) method to large-size proteins such as Mad2. QSAR models were built based on available published data on 23 Mad2 mutants inducing CIN-related functional changes. The most relevant descriptors identified for predicting Mad2 native and mutants action mechanism and their involvement in genetic disorders are the steric (van der Waals area and solvent accessible area and their subdivided) and energetic van der Waals energy descriptors. The reliability of our QSAR models is indicated by significant values of statistical coefficients: Cross-validated correlation q2 (0.53–0.65) and fitted correlation r2 (0.82–0.90). Moreover, based on established QSAR equations, we rationally design and analyze nine de novo Mad2 mutants as possible promoters of CIN.
Indicator of Exo-Solar Planet(s) in the Circumstellar Disk Around β Pictoris

Our efficient numerical approach has been applied to modeling the asymmetric circumstellar dust disk around β Pictoris as observed with the HST/STIS. We present a new model on the origin of the warping of the β Pic disk. We suggest that the observed warp is formed by the gravitational influence of a planet with a mass of about 10 masses of Earth, at a distance of 70 AU, and a small inclination (∽ 2.5°) of the planetary orbit to the main dust disk. Results of our modeling are compared with the STIS observations.
Detection and filtering of short-term (1/f) noise in inertial sensors

Systematic and random errors inherently present in all inertial sensors contribute to the long-term divergence of the navigation solution of an Inertial Navigation System (INS). To keep such long-term divergence under control while taking advantage of their excellent short-term performance, an INS is often combined with information from other navigation aids. However, the improvements due to external aiding are limited by the type, accuracy and update period of the information provided by the aid(s). In the case where an INS is aided by GPS, only the long-term inertial errors are suppressed while the short-term inertial errors essentially remain unaffected. A better navigation solution can therefore be expected if most of the short-term inertial sensor noise is reduced prior to data integration. This paper describes a method of inertial data pre-filtering over the frequency band of interest, i.e. between the measurement period of external aiding with GPS and the edge of the motion band. A model for the short-term inertial errors in this band is introduced as a combination of a broad band signal with noise possessing self-similarities over several decades of frequency. The model is defined in the frequency and wavelet domains. A technique for adaptive estimation of the model parameters is introduced. This method is based on an analysis of a short portion of data above the band of interest. Once the model parameters are estimated for a specific system and time-period, the noise distribution is predicted within the band of interest and the signals are de-noised. This filtering methodology is tested using different navigation-grade strapdown inertial systems and the results are presented. A 20% improvement in the attitude determination has been observed under the dynamic conditions with respect to an independent reference.
Generating Predictive Inferences When Multiple Alternatives Are Available

ABSTRACT The generation of predictive inferences may be difficult when a story leads to multiple possible consequences. The present study examined whether inferences are generated when the story implies two mutually exclusive consequences are nearly equally likely to occur. Experiment 1 used a word-naming task and showed that neither inference was activated when probed at 500 ms after the story, suggesting the alternative inference interfered with activation of the targeted inference. Experiment 2 used a contradictory reading paradigm and showed that reading time was slower when a sentence contradicted both inferences but not when it contradicted only one inference. These results imply that both inferences were generated but at a minimal level of activation so that they were not detected in a word-naming task. The results are discussed in the light of comprehension theories that could account for the representation of minimally encoded inferences.