Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of the Performance of the TES Algorithm Over Urban Areas

The temperature and emissivity separation (TES) algorithm is used to retrieve the land surface emissivity (LSE) and land surface temperature (LST) values from multispectral thermal infrared sensors. In this paper, we analyze the performance of this methodology over urban areas, which are characterized by a large number of different surface materials, a variability in the lowest layer of the atmospheric profiles, and a 3-D structure. These specificities induce errors in the LSE and LST retrieval, which should be quantified. With this aim, the efficiency of the TES algorithm over urban materials, the atmospheric correction, and the impact of the 3-D architecture of urban scenes are analyzed. The method is based on the use of a 3-D radiative transfer tool, TITAN, for modeling all of the radiative components of the signal registered by a sensor. From the sensor radiance, an atmosphere compensation process is applied, followed by a TES methodology that considers the observed scene to be a flat surface. Finally, the retrieved LSE and LST are compared with the original parameters. Results show the following: First, the TES algorithm used reproduces the LSE (LST) of urban materials within a root-mean-square error (rmse) of 0.017 (0.9 K). Second, 20% of uncertainty in the water vapor content of the total atmosphere introduces an rmse of 0.005 (0.4 K) for the LSE (LST) product. Third, in a standard case, the 3-D structure of an urban canyon leads to an rmse of 0.005 (0.2 K) for the LSE (LST) retrieval of the asphalt at the bottom of the scene.
TEST OF FABRICATED TUBULAR COLUMNS

Described herein are tests of 10 long fabricated tubular steel columns, of relatively large diameter, with essentially pine-ended conditions. In addition to the behavior, strength, and the manner of failure of the long columns, a number of stub column tests were also made along with the measurements of residual stresses. These residual stresses are both circumferential, due to formation of a flat plate into a cylindrical shape; and longitudinal, resulting from the welding of longitudinal seam needed to complete the fabricated cylinder. Measurement of these stresses is considered essential to any theoretical analysis of column behavior. The maximum strength of the 10 long columns tested (at diameter-to-thickness ratios of 48 and 70 and with a range of slenderness ratio between 39 to 83) is compared with the CRC column curve and good agreement is generally observed.
Laparoscopic Sigmoid Resection for Diverticulitis Decreases Major Morbidity Rates: A Randomized Control Trial: Short-term Results of the Sigma Trial

Background:No randomized controlled trial has compared laparoscopic sigmoid resection (LSR) to open sigmoid resection (OSR) for symptomatic diverticulitis of the sigmoid colon. This study tested the hypothesis that LSR is associated with decreased postoperative complication rates as compared with OSR. Methods:This was a prospective, multicenter, double-blind, parallel-arm, randomized controlled trial. Eligible patients were randomized to either LSR or OSR. Endpoints included postoperative mortality, and complications were classified as major and minor. The generator of the allocation sequence was separated from the executor. Blinding was ensured using an opaque wound dressing to cover the abdomen. Symptomatic diverticulitis of the sigmoid colon was defined as recurrent disease Hinchey I, IIa, IIb, symptomatic stricture, or severe rectal bleeding. The decision to discharge patients was made by independent physicians blind to the allocation sequence. Data were analyzed according to the intention to treat principle. Results:From 2002 to 2006, 104 patients were randomized in 5 centers. All patients underwent the allocated intervention. Fifty-two LSR patients were comparable to 52 OSR patients for gender, age, BMI, ASA grade, comorbid conditions, previous abdominal surgery, and indication for surgery. LSR took longer (P = 0.0001) but caused less blood loss (P = 0.033). Conversion rate was 19.2%. Mortality rate was 1%. There were significantly more major complications in OSR patients (9.6% vs. 25.0%; P = 0.038). Minor complication rates were similar (LSR 36.5% vs. OSR 38.5%; P = 0.839). LSR patients had less pain (Visual Analog Scale 1.6; P = 0.0003), systemic analgesia requirement (P = 0.029), and returned home earlier (P = 0.046). The short form-36 questionnaire showed significantly better quality of life for LSR. Conclusions:LSR was associated with a 15.4% reduction in major complication rates, less pain, improved quality of life, and shorter hospitalization at the cost of a longer operating time.
Differential Clinicopathological Risk and Prognosis of Major Papillary Thyroid Cancer Variants.

CONTEXT Individualized management, incorporating papillary thyroid cancer (PTC) variant-specific risk, is conceivably a useful treatment strategy for PTC, which awaits comprehensive data demonstrating differential risks of PTC variants to support. OBJECTIVE This study sought to establish the differential clinicopathological risk of major PTC variants: conventional PTC (CPTC), follicular-variant PTC (FVPTC), and tall-cell PTC (TCPTC). METHODS This was a retrospective study of clinicopathological outcomes of 6282 PTC patients (4799 females and 1483 males) from 26 centers and The Cancer Genome Atlas in 14 countries with a median age of 44 years (interquartile range, 33-56 y) and median follow-up time of 37 months (interquartile range, 15-82 mo). RESULTS The cohort consisted of 4702 (74.8%) patients with CPTC, 1126 (17.9%) with FVPTC, and 239 (3.8%) with TCPTC. The prevalence of high-risk parameters was significantly different among the three variants, including extrathyroidal invasion, lymph node metastasis, stages III/IV, disease recurrence, mortality, and the use (need) of radioiodine treatment (all P < .001), being highest in TCPTC, lowest in FVPTC, and intermediate in CPTC, following an order of TCPTC > CPTC ≫ FVPTC. Recurrence and mortality in TCPTC, CPTC, and FVPTC were 27.3 and 6.7%, 16.1 and 2.5%, and 9.1 and 0.6%, corresponding to events per 1000 person-years (95% confidence interval [CI]) of 92.47 (64.66-132.26) and 24.61 (12.31-49.21), 34.46 (30.71-38.66), and 5.87 (4.37-7.88), and 24.73 (18.34-33.35) and 1.68 (0.54-5.21), respectively. Mortality hazard ratios of CPTC and TCPTC over FVPTC were 3.44 (95% CI, 1.07-11.11) and 14.96 (95% CI, 3.93-56.89), respectively. Kaplan-Meier survival analyses showed the best prognosis in FVPTC, worst in TCPTC, and intermediate in CPTC in disease recurrence-free probability and disease-specific patient survival. This was particularly the case in patients at least 45 years old. CONCLUSION This large multicenter study demonstrates differential prognostic risks of the three major PTC variants and establishes a unique risk order of TCPTC > CPTC ≫ FVPTC, providing important clinical implications for specific variant-based management of PTC.
A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media

Acute otitis media (AOM) caused by Streptococcus pneumoniae remains one of the most common infectious diseases worldwide despite widespread vaccination. A major limitation of the currently licensed pneumococcal vaccines is the lack of efficacy against mucosal disease manifestations such as AOM, acute bacterial sinusitis and pneumonia. We sought to generate a novel class of live vaccines that (1) retain all major antigenic virulence proteins yet are fully attenuated and (2) protect against otitis media. A live vaccine candidate based on deletion of the signal recognition pathway component ftsY induced potent, serotype‐independent protection against otitis media, sinusitis, pneumonia and invasive pneumococcal disease. Protection was maintained in animals coinfected with influenza virus, but was lost if mice were depleted of CD4+ T cells at the time of vaccination. The live vaccine induced a strong serum IgG2a and IgG2b response that correlated with CD4+ T‐cell mediated class switching. Deletion of genes required for microbial adaptation to the host environment is a novel live attenuated vaccine strategy yielding the first experimental vaccine effective against pneumococcal otitis media.
Effect of Rubber Nanoparticle Agglomeration on Properties of Thermoplastic Vulcanizates during Dynamic Vulcanization

We previously reported that the dispersed rubber microparticles in ethylene-propylene-diene monomer (EPDM)/polypropylene (PP) thermoplastic vulcanizates (TPVs) are actually agglomerates of rubber nanoparticles. In this study, based on this new understanding of the microstructure of TPV, we further revealed the microstructure-properties relationship of EPDM/PP TPV during dynamic vulcanization, especially the effect of the size of rubber nanoparticle agglomerates (dn), the thicknesses of PP ligaments (IDpoly) and the rubber network on the properties of EPDM/PP TPV. We were able to simultaneously obtain a high tensile strength, elongation at break, elastic modulus, and elasticity for the EPDM/PP TPV by the achievement of a smaller dn, a thinner IDpoly and a denser rubber network. Interestingly, the effect of dn and IDpoly on the elastic modulus of EPDM/PP TPV composed of rubber nanoparticle agglomerates is different from that of EPDM/PP TPVs composed of rubber microparticles reported previously. The deformation behavior of the TPVs during stretching was studied to understand the mechanism for the achievement of good mechanical properties. Interestingly, the rubber nanoparticle agglomerates are oriented along the tensile direction during stretching. The TPV samples with smaller and more numerous rubber nanoparticle agglomerates can slow down the development of voids and cracks more effectively, thus leading to increase in tensile strength and elongation at break of the EPDM/PP TPV.
Acylated and unacylated ghrelin inhibit atrophy in myotubes co-cultured with colon carcinoma cells

Cancer cachexia is a result of increased protein degradation and decreased protein synthesis. The multifunctional circulating hormone ghrelin promotes synthesis and inhibits degradation of muscle protein, but its mechanism of action is not fully understood. Here, we investigated whether co-culturing C2C12 myotubes with CT26 colon carcinoma cells induces myotube atrophy, and whether acylated ghrelin (AG) and unacylated ghrelin (UnAG) had anti-atrophic effects. We found that co-culture induced myotube atrophy and increased tumor necrosis factor-alpha (TNF-α) and myostatin concentrations in the culture medium. Moreover, co-culture down-regulated myogenin and MyoD expression, inhibited the Akt signaling, up-regulated ubiquitin E3 ligase expression, and activated the calpain system and autophagy in myotubes. Both AG and UnAG inhibited these changes. Our study describes a novel in vitro model that can be employed to investigate cancer cachexia, and our findings suggest a possible use for AG and UnAG in treating cancer cachexia.
Comparative performance analysis of adaptive multispectral detectors

The fully adaptive hypothesis testing algorithm developed by I.S. Reed and X. Yu (1990) for detecting low-contrast objects of unknown spectral features in a nonstationary background is extended to the case in which the relative spectral signatures of objects can be specified in advance. The resulting background-adaptive algorithm is analyzed and shown to achieve robust spectral feature discrimination with a constant false-alarm rate (CFAR) performance. A comparative performance analysis of the two algorithms establishes some important theoretical properties of adaptive spectral detectors and leads to practical guidelines for applying the algorithms to multispectral sensor data. The adaptive detection of man-made artifacts in a natural background is demonstrated by processing multiband infrared imagery collected by the Thermal Infrared Multispectral Scanner (TIMS) instrument. >
PPARA Intron Polymorphism Associated with Power Performance in 30-s Anaerobic Wingate Test

To date, polymorphisms in several genes have been associated with a strength/power performance including alpha 3 actinin, ciliary neurotrophic factor, vitamin D receptor, or angiotensin I converting enzyme, underlining the importance of genetic component of the multifactorial strength/power-related phenotypes. The single nucleotide variation in peroxisome proliferator-activated receptor alpha gene (PPARA) intron 7 G/C (rs4253778; g.46630634G>C) has been repeatedly found to play a significant role in response to different types of physical activity. We investigated the effect of PPARA intron 7 G/C polymorphism specifically on anaerobic power output in a group of 77 elite male Czech ice hockey players (18–36 y). We determined the relative peak power per body weight (Pmax.kg−1) and relative peak power per fat free mass (W.kg−1 FFM) during the 30-second Wingate Test (WT30) on bicycle ergometer (Monark 894E Peak bike, MONARK, Sweden). All WT30s were performed during the hockey season. Overall genotype frequencies were 50.6% GG homozygotes, 40.3% CG heterozygotes, and 9.1% CC homozygotes. We found statistically significant differences in Pmax.kg−1 and marginally significant differences in Pmax.kg−1 FFM values in WT30 between carriers and non-carriers for C allele (14.6±0.2 vs. 13.9±0.3 W.kg−1 and 15.8±0.2 vs. 15.2±0.3 W.kg−1 FFM, P = 0.036 and 0.12, respectively). Furthermore, Pmax.kg−1 FFM strongly positively correlated with the body weight only in individuals with GG genotypes (R = 0.55; p<0.001). Our results indicate that PPARA 7C carriers exhibited higher speed strength measures in WT30. We hypothesize that C allele carriers within the cohort of trained individuals may possess a metabolic advantage towards anaerobic metabolism.
A bio-inspired distributed approach for searching underwater acoustic source using a team of AUVs

We present a bio-inspired distributed algorithm which is a fusion of two distinct animal behaviours to solve three different underwater search missions. One of the two constituent control modules is called target-drive which models the hypothesized behaviour of a fish-larva searching for a coral reef using acoustic cues. Target-drive helps a single Autonomous Underwater Vehicle (AUV) to adjust its heading towards the acoustic source. The other control module called group-cohesion, mimics movements of a golden shiner (Notemigonus crysoleucas) in a school of fish. The proposed approach only relies on implicit communication and achieves target convergence only by assuming a single on-board hydrophone and location estimate of AUV's neighbours. The effects of varying key parameters such as group-size and neighbourhood-radius on convergence times have been thoroughly investigated. We present a preliminary analysis of the algorithm's performance which shows promise in solving problems employing small teams of AUVs in terms of convergence times and non-existent inter-agent communication.
FCERI and Histamine Metabolism Gene Variability in Selective Responders to NSAIDS

The high-affinity IgE receptor (Fcε RI) is a heterotetramer of three subunits: Fcε RIα, Fcε RIβ, and Fcε RIγ (αβγ2) encoded by three genes designated as FCER1A, FCER1B (MS4A2), and FCER1G, respectively. Recent evidence points to FCERI gene variability as a relevant factor in the risk of developing allergic diseases. Because Fcε RI plays a key role in the events downstream of the triggering factors in immunological response, we hypothesized that FCERI gene variants might be related with the risk of, or with the clinical response to, selective (IgE mediated) non-steroidal anti-inflammatory (NSAID) hypersensitivity. From a cohort of 314 patients suffering from selective hypersensitivity to metamizole, ibuprofen, diclofenac, paracetamol, acetylsalicylic acid (ASA), propifenazone, naproxen, ketoprofen, dexketoprofen, etofenamate, aceclofenac, etoricoxib, dexibuprofen, indomethacin, oxyphenylbutazone, or piroxicam, and 585 unrelated healthy controls that tolerated these NSAIDs, we analyzed the putative effects of the FCERI SNPs FCER1A rs2494262, rs2427837, and rs2251746; FCER1B rs1441586, rs569108, and rs512555; FCER1G rs11587213, rs2070901, and rs11421. Furthermore, in order to identify additional genetic markers which might be associated with the risk of developing selective NSAID hypersensitivity, or which may modify the putative association of FCERI gene variations with risk, we analyzed polymorphisms known to affect histamine synthesis or metabolism, such as rs17740607, rs2073440, rs1801105, rs2052129, rs10156191, rs1049742, and rs1049793 in the HDC, HNMT, and DAO genes. No major genetic associations with risk or with clinical presentation, and no gene-gene interactions, or gene-phenotype interactions (including age, gender, IgE concentration, antecedents of atopy, culprit drug, or clinical presentation) were identified in patients. However, logistic regression analyses indicated that the presence of antecedents of atopy and the DAO SNP rs2052129 (GG) were strongly related (P < 0.001 and P = 0.005, respectively) with selective hypersensitivity to ibuprofen. With regard to patients with selective hypersensitivity to ASA, men were more prone to develop such a reaction than women (P = 0.011), and the detrimental DAO SNP rs10156191 in homozygosity increased the risk of developing such hypersensitivity (P = 0.039).
Testosterone-induced adult neurosphere growth is mediated by sexually-dimorphic aromatase expression

We derived adult neural stem/progenitor cells (NSPCs) from the sub-ventricular zone of male and female mice to examine direct responses to principal sex hormones. In the presence of epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF2) NSPCs of both sexes expressed nestin and sox2, and could be maintained as neurospheres without addition of any sex hormones. The reverse was not observed; neither testosterone (T), 17β-estradiol (E2) nor progesterone (P4) was able to support neurosphere growth in the absence of EGF and FGF2. Ten nanomolar T, E2 or P4 induced nestin(+) cell proliferation within 20 min and enhanced neurosphere growth over 7 days irrespective of sex, which was abolished by Erk inhibition with 20 μM U0126. Maintaining neurospheres with each sex hormone did not affect subsequent neuronal differentiation. However, 10 nM T, E2 or P4 added during differentiation increased βIII tubulin(+) neuron production with E2 being more potent compared to T and P4 in both sexes. Androgen receptor (AR) inhibition with 20 μM flutamide but not aromatase inhibition with 10 μM letrozole reduced basal and T-induced neurosphere growth in females, while only concurrent inhibition of AR and aromatase produced the same effect in males. This sex-specific effect was supported by higher aromatase expression in male neurospheres compared to females measured by Western blot and green fluorescent protein (GFP) reporter. Ten micromolar menadione induced oxidative stress, impaired neurosphere growth and up-regulated aromatase expression in both sexes. However, under oxidative stress letrozole significantly exacerbated impaired neurosphere growth in males only. While both E2 and T could prevent oxidative stress-induced growth reduction in both sexes, the effects of T were dependent on innate aromatase activity. We show for the first time that intrinsic androgen and estrogen signaling may impact the capacity of NSPCs to produce neural progenitors under pathological conditions of oxidative stress.
Hydrogen influence on Brillouin and Rayleigh distributed temperature or strain sensors

Distributed optical fiber sensors are a clue technology for the monitoring of geological repository for long-lived nuclear wastes. Environment includes hydrogen whose influence on Rayleigh and Brillouin scatterings is experimentally evaluated. Induced propagation losses are quantified, as a function of wavelength and fiber dopants. 1310nm resulted the most favorable working wavelength. Distance range would anyway be reduced down to a hundred meter. We show hydrogen also induces Brillouin frequency shifts, up to 21MHz which corresponds to large temperature and strain measuring errors if not corrected. Fluorine fibers appeared more sensitive for short hydrogen exposure than other tested fibers.
Population Heterogeneity of Salmonella enterica Serotype Typhimurium Resulting from Phase Variation of the lpf Operon In Vitro and In Vivo

ABSTRACT The lpf fimbrial operon oscillates between phase ON and phase OFF expression states, thereby generating heterogeneity within S. enterica serotype Typhimurium populations with regard to expression of long polar fimbrial antigens. To determine whether the proportion of lpf phase variants changes with growth conditions, the lpf phase ON content of cultures was determined after in vitro and in vivo passage. After passage in Luria-Bertani (LB) broth for 120 generations, 96% of cells in a serotype Typhimurium culture carried the lpf operon in the phase ON expression state, regardless of the phase ON/OFF ratio in the inoculum. In contrast, a culture passaged on LB agar plates for 500 generations contained approximately 2% lpf phase ON cells. Differences in the lpf phase ON content of cultures passaged in broth and on plates were not caused by an outgrowth of lpf phase ON or lpf phase OFF cells, since deletion of lpf biosynthesis genes did not alter the phase ON/OFF ratio attained after passage. Instead, growth in LB broth resulted in a eightfold increase in the phase OFF-to-ON transition frequency and a decrease of the lpf phase ON-to-OFF transition frequency by a factor of 150 compared to growth on LB agar plates. After infection of naïve CBA/J mice with an lpf phase ON culture of serotype Typhimurium, the proportion of lpf phase ON cells continuously decreased over time, regardless of whether the strain carried intact fimbrial biosynthesis genes. These data suggest that elaboration of fimbriae does not have a major influence on the population heterogeneity produced by phase variation of the lpf operon in naïve mice.