Miracle-dz/UniFAR-FTUs huggingface dataset:
Postpartum aHUS Secondary to a Genetic Abnormality in Factor H Acquired Through Liver Transplantation

We report here a young female who underwent a successful deceased donor liver transplant for hepatic vein thrombosis. Five years after transplantation she developed postpartum atypical hemolytic uremic syndrome (aHUS). She did not recover renal function. Mutation screening of complement genes in her DNA did not show any abnormality. Mutation screening of DNA available from the donor showed a nonsense CFH mutation leading to factor H deficiency. Genotyping of the patient showed that she was homozygous for an aHUS CD46 at‐risk haplotype. In this individual, the development of aHUS has been facilitated by the combination of a trigger (pregnancy), an acquired rare genetic variant (CFH mutation) and a common susceptibility factor (CD46 haplotype).
Similar prompts may not be similar in the performance they elicit: Examining fluency, complexity, accuracy, and lexis in narratives from five picture prompts

Only a few characteristics of picture-based narrative prompts have been studied to determine what features affect task performance. Thus, it is not easy to identify equivalent narrative prompts or identify features that are impactful. Tavakoli and Foster (2008) and Tavakoli (2009) examined the impact of prompt on the language produced by English learners during a picture-based narrative task in respect to narrative structure and storyline complexity. This study investigates if prompts within these known categories elicit similar performance. Considering the findings based on different prompts in Tavakoli and Foster, as well as in Robinson’s (2011) Triadic Componential Framework for pedagogical tasks, we added another feature, number of elements. All of the prompts in this study had a tight sequential structure (±causal reasoning), similar storyline complexity (±intentional reasoning), and similar main characters and props (±elements). Although the accuracy and complexity in the ESL narratives were similar across prompts, there were some unexpected differences in fluency and lexis. Potential explanations of the variation in these subareas of language performance are discussed. Overall, this study highlights the importance of piloting research and testing materials and of investigating features that constitute task complexity.
The efficacy and characteristics of warm-up and re-warm-up practices in soccer players: a systematic review.

INTRODUCTION This review aimed 1) to evaluate the current research that examines the efficacy of warm-up (WU) and re-warm-up (RWU) on physical performance; and 2) to highlight the WU and RWU characteristics that optimise subsequent performance in soccer players. EVIDENCE ACQUISITION A computerized search was performed in the PubMed, ScienceDirect and Google Scholar (from 1995 to December 2015) for English-language, peer-reviewed investigations using the terms "soccer" OR "football" AND "warm-up" OR "stretching" OR "post-activation potentiation" OR "pre-activity" OR "re-warm-up" AND "performance" OR "jump" OR "sprint" OR "running". EVIDENCE SYNTHESIS Twenty seven articles were retrieved. Particularly, 22 articles examined the effects of WU on soccer performance and 5 articles focused on the effects of RWU. Clear evidence exists supporting the inclusion of dynamic stretching or postactivation potentiation-based exercises within a WU as acute performance enhancements were reported (pooled estimate changes of +3.46% and +4.21%, respectively). The FIFA 11+ WU also significantly increases strength, jump, speed and explosive performances (changes from 1% to 20%). At half-time, active RWU protocols including postactivation potentiation practices and multidirectional speed drills attenuate temperature and performance reductions induced by habitual practice. The data obtained in the present review showed that the level of play did not moderate the effectiveness of WU and RWU on soccer performance. CONCLUSIONS This review demonstrated that a static stretching WU reduced acute subsequent performance, while WU activities that include dynamic stretching, PAP-based exercises, and the FIFA 11+ can elicit positive effects in soccer players. The efficacy of an active RWU during half-time is also justified.
Bilateral lesions of the paraventricular hypothalamic nucleus disrupt nursing behavior in rabbits

Doe rabbits nurse the litter only once a day, for around 3 min, with circa 24‐h periodicity. To explore the participation of the paraventricular nucleus (PVN) in regulating this behavior, we lesioned it bilaterally with kainic acid on lactation day 7. Bilateral lesions, comprising less than 50% of the total PVN volume, abolished nursing behavior (4/8 does) or severely disrupted its normal periodicity (4/8 does). In the latter case, duration of nursing bouts was normal. Body weight, food and water intake were not significantly affected by bilateral PVN lesions. Unilateral lesions of the PVN or lesions located outside this nucleus did not significantly alter nursing periodicity or any other behavioral parameter. Results indicate an important role of the PVN for (i) maintaining maternal behavior, and (ii) the periodic display of nursing across lactation in rabbits.
Cigarette Smoking and Lung Cancer: Modeling Effect Modification of Total Exposure and Intensity

Background: A recent analysis indicates that the excess odds ratio for lung cancer by smoking is described by a function that is linear in pack-years and exponential in the logarithm of smoking intensity and its square (Cancer Epidemiol Biomarkers Prev. 2006;15:517–523). The model suggests that below 15–20 cigarettes per day there is a “direct exposure rate” effect, ie, the excess odds ratio per pack-year for higher intensity (and shorter duration) smokers is greater than for lower-intensity (and longer duration) smokers. Above 20 cigarettes per day, there is an “inverse-exposure-rate” effect, ie, the excess odds ratio per pack-year for higher intensity smokers is smaller than for lower-intensity smokers. Methods: Using pooled data from 2 large case-control studies of lung cancer (the European Smoking and Health Study and the German Radon Study), we evaluated effect modification of the association between smoking and lung cancer. Results: Interaction effects are very specific. Variations in risk of lung cancer with years since cessation of smoking, age, method of inhalation, and type of cigarette result from interactions with smoking intensity, and not total pack-years. In contrast, risk variations by sex result from the interaction with total pack-years, while intensity effects are homogeneous. Risk variations by age at which smoking started result from interactions with both total pack-years and intensity. All intensity interactions are homogeneous across studies. Conclusions: The specificity of the interactions may provide clues for the molecular basis of the smoking and lung cancer relationship.
Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans

ABSTRACT Antiviral RNA-mediated silencing (RNA interference [RNAi]) acts as a powerful innate immunity defense in plants, invertebrates, and mammals. In Caenorhabditis elegans, RNAi is systemic; i.e., RNAi silencing signals can move between cells and tissues. Furthermore, RNAi effects can be inherited transgenerationally and may last for many generations. Neither the biological relevance of systemic RNAi nor transgenerational RNAi is currently understood. Here we examined the role of both pathways in the protection of C. elegans from viral infection. We studied the Orsay virus, a positive-strand RNA virus related to Nodaviridae and the first and only virus known to infect C. elegans. Immunity to Orsay virus infection requires the RNAi pathway. Surprisingly, we found that genes required for systemic or transgenerational RNAi did not have a role in antiviral defense. Furthermore, we found that Orsay virus infection did not elicit a systemic RNAi response even when a target for RNAi was provided by using transgenes. Finally, we show that viral siRNAs, the effectors of RNAi, are not inherited to a level that provides any significant resistance to viral infection in the next generation. We conclude that systemic or transgenerational RNAi does not play a role in the defense against natural Orsay virus infection. Furthermore, our data suggest that there is a qualitative difference between experimental RNAi and antiviral RNAi. Our data are consistent with a model of systemic and transgenerational RNAi that requires a nuclear or germ line component that is lacking in almost all RNA virus infections. IMPORTANCE Since its discovery in Caenorhabditis elegans, RNAi has proven a valuable scientific tool in many organisms. In C. elegans, exogenous RNAi spreads throughout the organism and can be passed between generations; however, there has been controversy as to the endogenous role(s) that the RNAi pathway plays. One endogenous role for which spreading both within the infected organism and between generations would be advantageous is a role in viral defense. In plants, antiviral RNAi is systemic and the spread of RNAi between cells provides protection against subsequent viral infection. Here we investigated this by using the only naturally occurring virus known to infect C. elegans, Orsay virus, and surprisingly found that, in contrast to the exogenous RNAi pathway, the antiviral RNAi response targeted against this virus does not spread systemically throughout the organism and cannot be passed between generations. These results suggest that there are differences between the two pathways that remain to be discovered.
Trehalose, a temperature‐ and salt‐induced solute with implications in pathobiology of Acinetobacter baumannii

Acinetobacter baumannii is an opportunistic human pathogen that has become a global threat to healthcare institutions worldwide. A major factor contributing to success of this bacterium is its outstanding ability to survive on dry surfaces. The molecular basis for desiccation resistance is not completely understood. This study focused on growth under osmotic stress and aimed to identify the pool of compatible solutes synthesized in response to these low water activity conditions. A. baumannii produced mannitol as compatible solute, but in contrast to Acinetobacter baylyi, also trehalose was accumulated in response to increasing NaCl concentrations. The genome of A. baumannii encodes a trehalose-6-phosphate phosphatase (OtsB) and a trehalose-6-phosphate synthase (OtsA). Deletion of otsB abolished trehalose formation, demonstrating that otsB is essential for trehalose biosynthesis. Growth of the mutant was neither impaired at low salt nor at 500 mM NaCl, but it did not grow at high temperatures, indicating a dual function of trehalose in osmo- and thermoprotection. This led us to analyse temperature dependence of trehalose formation. Indeed, expression of otsB was not only induced by high osmolarity but also by high temperature. Concurrently, trehalose was accumulated in cells grown at high temperature. Taken together, these data point to an important role of trehalose in A. baumannii beyond osmoprotection.
Randomized Trial on Mindfulness Training for Smokers Targeted to a Disadvantaged Population

We report the results of a randomized trial comparing a novel smoking cessation treatment Mindfulness Training for Smokers (MTS) to a usual care therapy (Controls), which included the availability of a tobacco quit line and nicotine patches. Data were collected from 196 low socioeconomic status smokers in 2010–2011 in Madison, Wisconsin. Participants were randomized to either MTS or a telephonic quit line. The primary outcome was 6-month smoking abstinence measured by carbon monoxide breath testing and Time-Line Follow-Back. Among treatment initiators (randomized participants who participated in the intervention), abstinence rates were significantly different between the MTS (38.7%) and control (20.6%, p = .05) groups. Study limitations are also discussed. Results suggest that further study is warranted.
What Moderates the Too-Much-Choice Effect?

Core theories in economics,psychology,and marketing suggest that decision makers benefit from having more choice. In contrast, according to the too-much-choice effect,having too many options to choose from may ultimately decrease the motivation to choose and the satisfaction with the chosen option. To reconcile these two positions,we tested whether there are specific conditions in which the too-much-choice effect is more or less likely to occur. In three studies with a total of 598 participants,we systematically investigated the moderating impact of choice set sizes,option attractiveness,and whether participants had to justify their choices. We also tested the moderating role of search behavior,domain-specific expertise,and participants’ tendency to maximize,in a within-subject design. Overall,only choice justification proved to be an effective moderator,calling the extent of the too-much-choice effect into question. We provide a theoretical account for our findings and discuss possible pathways for future research. © 2009 Wiley Periodicals,Inc.
Epicardium-derived cells: a new source of regenerative capacity

Cardiovascular regenerative medicine aims to counter muscle loss post ischaemic disease with the identification of new cellular sources for cardiomyocyte replacement. A number of embryonic and adult cell models have been explored preclinically and in patient trials, but modest outcome, coupled with issues with impaired graft survival and limited/immature (trans-) differentiation alongside host rejection, has left the door open for more therapeutically efficacious sources of myocardial regeneration. Due to its fundamental role in heart development, the epicardium emerges as an obvious candidate. Here, recent findings are reviewed that show adult epicardium-derived cells as a new source of regenerative capacity for heart repair.
The Relationship Between Mastery Orientation and Maximal Oxygen Uptake Among Military Cadets: The Mediating Role of Intrinsic Motivation

ABSTRACT Drawing upon achievement goal theory (AGT) and self-determination theory (SDT), a longitudinal study was conducted among 248 military cadets across a two-year time span. The results showed that mastery orientation at Time 1 was positively associated with intrinsic motivation at Time 2 after controlling for intrinsic motivation at Time 1. Furthermore, intrinsic motivation assessed at Time 2 was positively associated with maximal oxygen uptake (VO2 max) at Time 3 after controlling for VO2 max at Time 2. This suggests that military cadets who strive to improve their personal performance (i.e., mastery-oriented individuals) are more likely to exhibit an increase in their level of VO2 max and that this increase can be attributed to increased intrinsic motivation.
HIV sequence diversity during the early phase of infection is associated with HIV DNA reductions during antiretroviral therapy

The association between baseline human immunodeficiency virus (HIV) sequence diversity and HIV DNA decay after the initiation of antiretroviral therapy (ART) remains uncharacterized during the early stages of HIV infection. Samples were obtained from a cohort of 17 patients with early HIV infection (<6 months after infection) who initiated ART, and the C2V5 region of the HIV‐1 envelope (env) gene was amplified via single genome amplification (SGA) to determine the peripheral plasma HIV quasispecies. We categorized HIV quasispecies into two groups according to baseline viral sequence genetic distance, which was determined by the Poisson–Fitter tool. Total HIV DNA in peripheral blood mononuclear cells (PBMCs), viral load, and T cell subsets were measured prior to and after the initiation of ART. The median SGA sequence number was 17 (range 6–28). At baseline, we identified 7 patients with homogeneous viral populations (designated the Homogeneous group) and 10 patients with heterogeneous viral populations (designated the Heterogeneous group) based on SGA sequences. Both groups exhibited similar HIV DNA decay rates during the first 6 months of ART (P > 0.99), but the Homogenous group experienced more prominent decay than the Heterogeneous group after 6 months (P = 0.037). The Heterogeneous group had higher CD4 cell counts after ART initiation; however, both groups had comparable recovery in terms of CD4/CD8 ratios and CD8 T cell activation levels. Viral population homogeneity upon the initiation of ART is associated with a decrease in HIV DNA levels during ART. J. Med. Virol. 89:982–988, 2017. © 2017 Wiley Periodicals, Inc.
Attribution-Based Treatment Interventions in Some Achievement Settings

Abstract Purpose This chapter presents empirical evidence on the effects of attributional retraining (AR), a motivation-enhancing treatment that can offset maladaptive explanatory mind-sets arising from adverse learning experiences. The evidence shows that AR is effective for assisting college students to adapt to competitive and challenging achievement settings. Design/methodology/approach This chapter describes the characteristics of AR protocols and details three primary advances in studying AR efficacy in terms of achievement performance, psychosocial outcomes, and processes that mediate AR-performance linkages. The psychological mechanisms that underpin AR effects on motivation and performance are outlined from the perspective of Weiner’s (1974, 1986, 2012) attribution theory. Findings Laboratory and field studies show that AR treatments are potent interventions that have short-term and long-lasting psychosocial, motivation, and performance benefits in achievement settings. Students who participate in AR programs are better off than their no-AR counterparts not just in their cognitive and affective prospects, but they also outperform their no-AR peers in class tests, course grades, and grade-point-averages, and are more persistent in terms of course credits and graduation rates. Originality/value This paper contributes to the emerging literature on treatment interventions in achievement settings by documenting key advances in the development of AR protocols and by identifying the next steps critical to moving the literature forward. Further progress in understanding AR efficacy will rest on examining the analysis of complex attributional thinking, the mediation of AR treatment effects, and the boundary conditions that moderate AR treatment efficacy.
Success Probability and Area Spectral Efficiency in Multiuser MIMO HetNets

We derive a general and closed-form result for the success probability in downlink multiple-antenna (MIMO) heterogeneous cellular networks (HetNets), utilizing a novel Toeplitz matrix representation. This main result, which is equivalently the signal-to-interference ratio (SIR) distribution, includes multiuser MIMO, single-user MIMO and per-tier biasing for K different tiers of randomly placed base stations (BSs), assuming zero-forcing precoding and perfect channel state information. The large SIR limit of this result admits a simple closed form that is accurate at moderate SIRs, e.g., above 5 dB. These results reveal that the SIR-invariance property of SISO HetNets does not hold for MIMO HetNets; instead the success probability may decrease as the network density increases. We prove that the maximum success probability is achieved by activating only one tier of BSs, while the maximum area spectral efficiency (ASE) is achieved by activating all the BSs. This reveals a unique tradeoff between the ASE and link reliability in multiuser MIMO HetNets. To achieve the maximum ASE while guaranteeing a certain link reliability, we develop efficient algorithms to find the optimal BS densities. It is shown that as the link reliability requirement increases, more BSs and more tiers should be deactivated.
Migration of the Lag Screw Within the Femoral Head: A Comparison of the Intramedullary Hip Screw and the Gamma Asia-Pacific Nail

Objectives To study the functional difference in the performances of sliding femoral head screws by comparing the displacement of the screw in relation to the femoral head in hips treated with the Gamma Asia-Pacific nail (GN) and hips treated with the intramedullary hip screw (IMHS). Study Design Retrospective review of prospectively collected data. Methods Displacement of the femoral head screw in relation to the femoral head was measured in fifty-six elderly patients with intertrochanteric fractures who were treated with an IMHS or GN. Displacement of the femoral head screw was determined by comparing screw position in the immediate postoperative radiograph with a film taken 3 months after surgery. Results In the GN group, significant displacement of the screw was observed with 3.8 ± 3.8 percent translation in the horizontal axis (P < 0.005) and 4.3 ± 5.1 percent displacement in the vertical axis (P < 0.05) in comparison with the diameter of the femoral head. In comparison, displacement of the femoral head screw was not observed with the IMHS (P = 0.48 for horizontal, P = 0.18 for vertical). Total displacement of the femoral head screw in relation to the femoral head in the GN was twice that observed in the IMHS (P < 0.001). Conclusion These results indicate that the displacement of the femoral head screw of the IMHS was less than the lag screw of the GN. However, it is still unknown whether this smaller displacement of the IMHS is clinically significant for reducing the rate of screw cut-out after surgery.
A Context-Aware Recurrent Encoder for Neural Machine Translation

Neural machine translation (NMT) heavily relies on its encoder to capture the underlying meaning of a source sentence so as to generate a faithful translation. However, most NMT encoders are built upon either unidirectional or bidirectional recurrent neural networks, which either do not deal with future context or simply concatenate the history and future context to form context-dependent word representations, implicitly assuming the independence of the two types of contextual information. In this paper, we propose a novel context-aware recurrent encoder (CAEncoder), as an alternative to the widely-used bidirectional encoder, such that the future and history contexts can be fully incorporated into the learned source representations. Our CAEncoder involves a two-level hierarchy: The bottom level summarizes the history information, whereas the upper level assembles the summarized history and future context into source representations. Additionally, CAEncoder is as efficient as the bidirectional RNN encoder in terms of both training and decoding. Experiments on both Chinese–English and English–German translation tasks show that CAEncoder achieves significant improvements over the bidirectional RNN encoder on a widely-used NMT system. 1