Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Fine Aggregate Grading on Properties of Cement Composite

The research describes the analysis of cement composites mixes based on fine aggregates. The natural fine aggregate was divided into 3 groups of fractions. Each of them contained particles of a diameter between specific limits. Such an approach enabled the authors to use a mixture experimental design based on triangular surfaces. The features of fresh cement composite mix and hardened cement composite based on the designed aggregates are shown on figures as contour plots. It has been experimentally demonstrated that fresh fine aggregate cement composites mixes are characterized by higher contents of air than mixes based on coarse aggregate. Moreover, strength increases together with both the increase of contents of the coarsest aggregate fractions and with a decrease of contents of the group of the finest fractions. The main subject of the analysis was to define optimal aggregate mixes for use in production of fine aggregate cement composite.
The Effect of Age on the V˙O2max Response to High-Intensity Interval Training

Purpose High-intensity interval training (HIIT) is documented to yield effective improvements in the cardiovascular system and be an excellent strategy for healthy aging. However, it is not determined how age may affect the training response of key components of aerobic endurance. Methods We recruited 72 males (mean ± SD, weight = 84.9 ± 12.9 kg, height = 180.4 ± 5.8 cm) and 22 females (weight = 76.0 ± 17.2 kg, height = 171.2 ± 6.7 cm) from 20 to 70+ yr with a training status typical for their age group and divided them into six decade cohorts. The participants followed supervised training with a targeted intensity of 90%–95% of maximal HR (HRmax) three times a week for 8 wk. Results After HIIT, all age groups increased (P < 0.001–P = 0.004) maximal oxygen consumption (V˙O2max) with 0.39 ± 0.20 (20–29 yr), 0.28 ± 0.21 (30–39 yr), 0.36 ± 0.08 (40–49 yr), 0.34 ± 0.27 (50–59 yr), 0.33 ± 0.23 (60–69 yr), and 0.34 ± 0.14 (70+ yr) L·min−1, respectively. These 9%–13% improvements were not significantly different between the age groups. In contrast to age, the percentage improvements after HIIT were inversely associated with baseline training status (r = 0.66, P < 0.001). HRmax was not altered within the respective age cohorts, but the two oldest cohorts exhibited a tendency (P = 0.07) to increase HRmax in contrast to a training-induced decrease in the younger cohorts. Conclusion In healthy individuals with an aerobic capacity typical for what is observed in the population, the training response is likely not affected by age in a short-term training intervention but may rather be affected by the initial training status. These findings imply that individuals across age all have a great potential for cardiovascular improvements, and that HIIT may be used as an excellent strategy for healthy aging.
Practitioner review: psychosocial treatments for conduct disorder in children.

The present paper reviews promising treatments for conduct disorder among children and adolescents. The treatments include problem-solving skills training, parent management training, functional family therapy and multisystemic therapy. For each treatment, conceptual underpinnings, characteristics and outcome evidence are highlighted. Limitations associated with these treatments (e.g. paucity of long-term follow-up evidence and of evidence for the clinical significance of the change) are also presented. Broader issues that affect treatment and clinical work with conduct-disordered youths are also addressed, including retaining cases in treatment, what treatments do not work, who responds well to treatment, comorbidity, the use of combined treatments and the need for new models of treatment delivery.
Answering UCQs under updates and in the presence of integrity constraints

We investigate the query evaluation problem for fixed queries over fully dynamic databases where tuples can be inserted or deleted. The task is to design a dynamic data structure that can immediately report the new result of a fixed query after every database update. We consider unions of conjunctive queries (UCQs) and focus on the query evaluation tasks testing (decide whether an input tuple belongs to the query result), enumeration (enumerate, without repetition, all tuples in the query result), and counting (output the number of tuples in the query result). We identify three increasingly restrictive classes of UCQs which we call t-hierarchical, q-hierarchical, and exhaustively q-hierarchical UCQs. Our main results provide the following dichotomies: If the query's homomorphic core is t-hierarchical (q-hierarchical, exhaustively q-hierarchical), then the testing (enumeration, counting) problem can be solved with constant update time and constant testing time (delay, counting time). Otherwise, it cannot be solved with sublinear update time and sublinear testing time (delay, counting time), unless the OV-conjecture and/or the OMv-conjecture fails. We also study the complexity of query evaluation in the dynamic setting in the presence of integrity constraints, and we obtain according dichotomy results for the special case of small domain constraints (i.e., constraints which state that all values in a particular column of a relation belong to a fixed domain of constant size).
Comprehensive Analysis of Cellular Galectin-3 Reveals No Consistent Oncogenic Function in Pancreatic Cancer Cells

Galectin-3 (Gal-3), a 31 kDa member of the family of beta-galactoside-binding proteins, has been implicated in the progression of different human cancers. However, the proposed roles differ widely, ranging from tumor-promoting cellular functions and negative impact on patient prognosis to tumor-suppressive properties and positive prognostic impact. We and others have previously identified Gal-3 as overexpressed in pancreatic cancer as compared to chronic pancreatitis and normal pancreatic tissue. The purpose of this study was thus the comprehensive analysis of putative cellular functions of Gal-3 by transient as well as stable silencing or overexpression of Gal-3 in a panel of 6 well-established pancreatic cancer cell lines. Our results confirm that galectin-3 is upregulated at the mRNA level in pancreatic cancer and strongly expressed in the majority of pancreatic cancer cell lines. In individual cell lines, transient knockdown of Gal-3 expression resulted in moderate inhibitory effects on proliferation, migration or anchorage-independent growth of the cells, but these effects were not consistent across the spectrum of analyzed cell lines. Moreover, functional effects of the modulation of Gal-3 expression were not observed in stable knockdown or overexpression approaches in vitro and did not alter the growth characteristics of nude mouse xenograft tumors in vivo. Our data thus do not support a direct functional role of Gal-3 in the malignant transformation of pancreatic epithelial cells, although paracrine or systemic effects of Gal-3 expression are not excluded.
Repetitive Deep TMS for Parkinson Disease: A 3-Month Double-Blind, Randomized Sham-Controlled Study

Purpose: To study the effects of a repetitive deep transcranial magnetic stimulation (rDTMS) in patients with Parkinson disease using the H5 coil for the low-frequency stimulation of the primary motor cortex, followed by the high-frequency rDTMS of the prefrontal cortex. Methods: The main outcome measures were the total and motor scores of the Unified Parkinson's Disease Rating Scale (UPDRS). Secondary measures included rating of depression and quantitative motor tasks. Results: Forty-eight patients were randomized 1:1 into real or sham rDTMS treatment arms. Analyses (n = 42) of both UPDRS scores revealed a significant main effect for time between baseline and day 90 (end of treatment), indicating that there was an improvement of both scores over time in the whole sample. Although effects of treatment and time-by-treatment were insignificant, simple effects analysis of both measures was significant in the rDTMS group and reached a P-value of 0.06 in the sham group. The response rate was higher in patients with longer disease duration and higher motor UPDRS scores. Side effects were more common in the rDTMS group but were transient and tolerable. Conclusions: Although rDTMS treatment exhibited some motor improvements, we could not demonstrate an advantage for real treatment over sham. Further research is required to establish stimulation parameters that may induce potentially more beneficial outcomes, probably in patients with longer and more sever disease.
Tool wear mechanisms in machining of three titanium alloys with increasing β-phase fraction

Mechanical and microstructural properties of titanium alloys change with β-phase fraction. This in turn influences the dominant tool wear mechanisms in their machining. This work therefore involves turning experimentation on three titanium alloys with varying β-phase fraction, namely, α, α+β and β-rich alloys using coated carbide tools, to identify dominant wear mechanisms, which hitherto have not been adequately investigated. The dominant wear mechanisms were investigated using scanning electron microscopy and energy-dispersive X-ray analysis of worn tool surfaces and were also correlated with the cutting forces during machining. Abrasion, abrasion with built-up edge and plastic deformation of cutting edge appeared to be the dominant tool wear mechanisms in α, α+β and β-rich alloy, respectively. At the same time, diffusion of Sn, V and Mo from α, α+β and β-rich alloys to tool face, respectively, was observed. The chip–tool contact length predicted using the analytical models from the literature matched closely with the experimental values.
Comparison of Heart Rate Variability Parameters to the Autonomic Reflex Screen in Postural Orthostatic Tachycardia Syndrome and Neurogenic Orthostatic Hypotension

Purpose: The clinical significance of heart rate variability (HRV) in the context of autonomic dysfunction continues to be a matter of debate. Therefore, the purpose of the current study was to investigate the clinical relevance of HRV in the context of autonomic dysfunction. Methods: Heart rate variability data from 225 volunteers consisting of controls (n = 166) and patients with mild (n = 25) and severe (n = 34) autonomic dysfunction were retrospectively analyzed. Time and frequency parameters were correlated against baseline and standardized tests of autonomic function. Results: During baseline, resting HR was negatively correlated with time (SD of all normal RR interval, r = −0.511; RMSSD, r = −0.585; pNN50, r = −0.545) and frequency (low-frequency, r = −0.362; high-frequency, r = −0.421) parameters (P < 0.01). Resting systolic blood pressure demonstrated similar significant correlations (P < 0.01). During head-up tilt, SD of all normal RR intervals was positively correlated with [INCREMENT]HR and change in systolic blood pressure (r = 0.340; r = 0.538, respectively; P < 0.01). Similarly, low-frequency, high-frequency, and low-frequency/high-frequency ratios were correlated with [INCREMENT]HR (r = 0.422, r = 0.176, r = 0.470) and change in systolic blood pressure (r = 0.451, r = 0.407, and r = 0.185) (P < 0.01). Time parameters (SD of all normal RR intervals, RMSSD, and pNN50) were all significantly correlated with deep breathing (r = 0.600; r = 0.556; r = 0.516; P < 0.01, respectively). Low-frequency and high-frequency power were also correlated (r = 0.596; r = 0.580, respectively) (P < 0.01). Conclusions: Time and frequency parameters showed significant negative correlations with baseline hemodynamics. During a test of sympathetic activation and parasympathetic withdrawal, this relationship shifted to reveal significant positive correlations between HRV parameters and hemodynamics. Last, during a test of parasympathetic activation, there were significant positive correlations with cardiovagally mediated HRV parameters. Overall, these results suggest broader clinical relevance for HRV parameters within the spectrum of autonomic functioning.
SpiNNaker: A 1-W 18-Core System-on-Chip for Massively-Parallel Neural Network Simulation

The modelling of large systems of spiking neurons is computationally very demanding in terms of processing power and communication. SpiNNaker - Spiking Neural Network architecture - is a massively parallel computer system designed to provide a cost-effective and flexible simulator for neuroscience experiments. It can model up to a billion neurons and a trillion synapses in biological real time. The basic building block is the SpiNNaker Chip Multiprocessor (CMP), which is a custom-designed globally asynchronous locally synchronous (GALS) system with 18 ARM968 processor nodes residing in synchronous islands, surrounded by a lightweight, packet-switched asynchronous communications infrastructure. In this paper, we review the design requirements for its very demanding target application, the SpiNNaker micro-architecture and its implementation issues. We also evaluate the SpiNNaker CMP, which contains 100 million transistors in a 102-mm2 die, provides a peak performance of 3.96 GIPS, and has a peak power consumption of 1 W when all processor cores operate at the nominal frequency of 180 MHz. SpiNNaker chips are fully operational and meet their power and performance requirements.
Functional subdivisions within the human intraparietal sulcus are involved in visuospatial transformation in a non‐context‐dependent manner

Object‐based visuospatial transformation is important for the ability to interact with the world and the people and objects within it. In this preliminary investigation, we hypothesized that object‐based visuospatial transformation is a unitary process invoked regardless of current context and is localized to the intraparietal sulcus. Participants (n = 14) performed both antisaccade and mental rotation tasks while scanned using fMRI. A statistical conjunction confirmed that both tasks activated the intraparietal sulcus. Statistical parametric anatomical mapping determined that the statistical conjunction was localized to intraparietal sulcus subregions hIP2 and hIP3. A Gaussian naïve Bayes classifier confirmed that the conjunction in region hIP3 was indistinguishable between tasks. The results provide evidence that object‐based visuospatial transformation is a domain‐general process that is invoked regardless of current context. Our results are consistent with the modular model of the posterior parietal cortex and the distinct cytoarchitectonic, structural, and functional connectivity profiles of the subregions in the intraparietal sulcus. Hum Brain Mapp 39:354–368, 2018. © 2017 Wiley Periodicals, Inc.
The Association Between the MAOA 2R Genotype and Delinquency Over Time Among Men

Using a panel of 6,001 males from the National Longitudinal Study of Adolescent and Adult Health, we examine potential moderation by paternal incarceration and parent–child closeness altering the relationship between the rare 2R MAOA genotype and delinquency. By jointly examining moderation patterns for both the mother and father with the transmission of the MAOA genotype from mother to son, we are able to make inferences about the specific genetic model that best explains these outcomes. In line with prior research, we find a direct relationship between the MAOA 2R genotype and delinquency, independent of parental incarceration and closeness. Examining moderation patterns, we find that delinquency risk for the 2R allele is buffered for males close to their biological or social father but not their biological mother. We conclude that the 2R-delinquency association is not due to passive gene–environment correlation but is best characterized as a social control Gene × Environment interaction.
Herpes Zoster and Dementia: A Nationwide Population-Based Cohort Study.

OBJECTIVE Some infectious diseases have been found to be associated with cognitive impairment and dementia. However, the relationship between herpes zoster and dementia has received little attention. This study aimed to investigate this association as well as associations of antiviral treatments for herpes zoster and incident dementia using a large national sample. METHODS Cases were identified from the Taiwan National Health Insurance Research Database with a new diagnosis of herpes zoster (ICD-9-CM code: 053) between 1997 and 2013. Each identified individual with a case of herpes zoster was compared with 1 sex-, age-, and residence-matched control subject. Both groups were followed until the first diagnosis of dementia (ICD-9-CM codes: 290.0 to 290.4, 294.1, 331.0 to 331.2, and 331.82), withdrawal from the registry, or the end of 2013. Cox regression analyses and competing risk model were applied, adjusting for sex, age, residence, depression, autoimmune disease, ischemic stroke, traumatic brain injury, alcohol use disorder, and antiviral treatments for herpes zoster to evaluate the risk of interest. RESULTS A total of 39,205 cases with herpes zoster were identified. Of the 78,410 study and comparison subjects, 4,204 were diagnosed as having dementia during a mean (SD) follow-up period of 6.22 (4.05) years. Herpes zoster was associated with a slightly increased risk of dementia in the fully adjusted model (hazard ratio [HR] = 1.11; 95% CI, 1.04-1.17). Prescriptions of antiviral therapy were associated with a reduced risk of developing dementia following the diagnosis of herpes zoster (HR = 0.55; 95% CI, 0.40-0.77). CONCLUSIONS Herpes zoster was associated with an increased risk of dementia, independent of potential confounding factors. Antiviral treatment might be protective in preventing dementia in patients with herpes zoster.
Calcium hydroxylapatite: A review on safety and complications

Radiesse®, or calcium hydroxylapatite (CaHA), is a biodegradable, biostimulatory soft tissue filler suitable for deeper folds and wrinkles. In the literature, good results have been documented with the use of CaHA and patient satisfaction scores are high. This study reviews the current literature on safety and complications of CaHA.
Formation of highly oxygenated organic molecules from aromatic compounds

Abstract. Anthropogenic volatile organic compounds (AVOCs) often dominate the urban atmosphere and consist to a large degree of aromatic hydrocarbons (ArHCs), such as benzene, toluene, xylenes, and trimethylbenzenes, e.g., from the handling and combustion of fuels. These compounds are important precursors for the formation of secondary organic aerosol. Here we show that the oxidation of aromatics with OH leads to a subsequent autoxidation chain reaction forming highly oxygenated molecules (HOMs) with an O : C ratio of up to 1.09. This is exemplified for five single-ring ArHCs (benzene, toluene, o-/m-/p-xylene, mesitylene (1,3,5-trimethylbenzene) and ethylbenzene), as well as two conjugated polycyclic ArHCs (naphthalene and biphenyl). We report the elemental composition of the HOMs and show the differences in the oxidation patterns of these ArHCs. A potential pathway for the formation of these HOMs from aromatics is presented and discussed. We hypothesize that AVOCs may contribute substantially to new particle formation events that have been detected in urban areas.
Regeneration and invasion of cottonwood riparian forest following wildfire

Populus deltoides is considered to be a weak resprouter and highly susceptible to wildfire, but few post‐wildfire studies have tracked P. deltoides response and resprouting within the Great Plains of North America. Following a wildfire in southwestern Kansas, U.S.A. , we surveyed burned and unburned areas of a cottonwood riparian forest along the Cimarron River that included a major understory invader, tamarisk (Tamarix ramosissima Ledeb.). We tested the following hypotheses, which are consistent with the current understanding of P. deltoides response to wildfire in the Great Plains: (1) regeneration of P. deltoides will be low in areas burned by the wildfire; (2) the number of dead P. deltoides individuals will be greater in the wildfire than unburned areas; and (3) tamarisk regeneration will be higher than P. deltoides regeneration in the wildfire areas because tamarisk is considered a stronger resprouter. We found evidence contrary to two of our hypotheses 3 years following the wildfire. (1) P. deltoides regeneration was high following the wildfire, averaging 692 individuals/ha. (2) The number of dead mature cottonwood trees was greater in wildfire plots than in unburned plots. (3) There was more P. deltoides regeneration than tamarisk regeneration following wildfire. These findings, which diverge from the majority of studies examining P. deltoides regeneration in the Great Plains, suggest that differing local environmental and forest stand conditions, coupled with the timing and intensity of the fire, could be important determinants of riparian forest species' responses to wildfire.
Estimation of skin optical parameters for real-time hyperspectral imaging applications

Abstract. Hyperspectral imaging combines high spectral and spatial resolution in one modality. This imaging technique is a promising tool for objective medical diagnostics. However, to be attractive in a clinical setting, the technique needs to be fast and accurate. Hyperspectral imaging can be used to analyze tissue properties using spectroscopic methods, and is thus useful as a general purpose diagnostic tool. We combine an analytic diffusion model for photon transport with real-time analysis of the hyperspectral images. This is achieved by parallelizing the inverse photon transport model on a graphics processing unit to yield optical parameters from diffuse reflectance spectra. The validity of this approach was verified by Monte Carlo simulations. Hyperspectral images of human skin in the wavelength range 400–1000 nm, with a spectral resolution of 3.6 nm and 1600 pixels across the field of view (Hyspex VNIR-1600), were used to develop the presented approach. The implemented algorithm was found to output optical properties at a speed of 3.5 ms per line of image data. The presented method is thus capable of meeting the defined real-time requirement, which was 30 ms per line of data.The algorithm is a proof of principle, which will be further developed.
Hydrothermal synthesis, crystal structure and properties of a two-dimensional uranyl coordination polymer based on a flexible zwitterionic ligand.

The interaction between the uranyl cation, (UO2)2+, and organic species is of interest due to the potential applications of the resulting compounds with regard to nuclear waste disposal and nuclear fuel reprocessing. The hydrothermal reaction of various uranyl compounds with flexible zwitterionic 1,1'-[1,4-phenylenebis(methylene)]bis(pyridin-1-ium-4-carboxylate) dihydrochloride (Bpmb·2HCl) in deionized water containing drops of H2SO4 resulted in the formation of a novel two-dimensional uranyl coordination polymer, namely poly[tetraoxido{μ2-1,1'-[1,4-phenylenebis(methylene)]bis(pyridin-1-ium-4-carboxylate)}di-μ3-sulfato-diuranium(VI)], [(UO2)2(SO4)2(C20H16N2O4)]n, (1). Single-crystal X-ray diffraction reveals that this coordination polymer exhibits a layered arrangement and the (UO2)2+ centre is coordinated by five equatorial O atoms. The structure was further characterized by FT-IR spectroscopy, powder X-ray diffraction (PXRD) and thermogravimetric analysis (TGA). The polymer shows high thermal stability up to 696 K. Furthermore, the photoluminescence properties of (1) has also been studied, showing it to exhibit a typical uranyl fluorescence.