Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinicopathological and prognostic significance of microRNA-107 in human non small cell lung cancer.

BACKGROUND MicroRNAs (miRNAs) are small, non-coding RNAs which can function as oncogenes or tumor suppressor genes in human cancers. Researchers have found that the expression level of miR-107 was decreased in human non-small cell lung cancer (NSCLC) tissues and cell lines, however, its clinicopathological and prognostic significance in NSCLC has not been investigated. METHODS Quantitative real-time PCR (qRT-PCR) was used to analyze the expression of miR-107 in 137 pairs of fresh NSCLC and matched adjacent normal tissue specimens. The chi-square test and Fishers exact tests were used to examine the associations between miR-107 expression and the clinicopathological characters. The overall survival (OS) and progression-free survival (PFS) were analyzed by log-rank test, and survival curves were plotted according to Kaplan-Meier. RESULTS The expression level of miR-107 was significantly lower in tumor tissues than that in corresponding noncancerous tissues (0.4676 ± 0.2078 vs. 1.000 ± 0.3953, P<0.001). Low expression of miR-107 was found to significantly correlate with TNM stage (p=0.001), regional lymph node involvement (p=0.04), and tumor differentiation (p=0.003). Kaplan-Meier analysis with the log-rank test indicated that low miR-107 expression had a significant impact on OS (35.2% vs. 69.3%; P=0.008) and PFS (30.0% vs. 56.2%; P=0.029). In a multivariate Cox model, we found that miR-107 expression was an independent poor prognostic factor for both 5-year OS (HR=2.57, 95% CI: 1.88-10.28; P=0.007) and 5-year PFS (HR=3.08, 95% CI: 2.01-8.92; P=0.003). CONCLUSION The expression of miR-107 was decreased in NSCLC. Low expression of miR-107 was significantly associated with tumor progression and decreased survival in patients with NSCLC, indicating that miR-107 may serve as a novel prognostic marker in NSCLC.
A Case Study of the Australian Plague Locust Commission and Environmental Due Diligence: Why Mere Legislative Compliance Is No Longer Sufficient for Environmentally Responsible Locust Control in Australia

Abstract The Australian Plague Locust Commission (APLC) manages locust populations across 2 million square kilometers of eastern Australia using the aerial application of chemical and biological control agents to protect agricultural production. This occurs via a preventative control strategy involving ultralow-volume spray equipment to distribute small droplets of control agent over a target area. The economic costs of, and potential gains stemming from, locust control are well documented. The application of insecticides, however, to fragile arid and semiarid ecosystems is a task that brings with it both real and perceived environmental issues. The APLC is proactive in addressing these issues through a combination of targeted environmental operational research, an ISO-14001–aligned Environmental Management System (EMS), and links with environmental regulatory and research institutions. Increasing due diligence components within Australian environmental legislation dictate that mere legislative compliance is no longer sufficient for industries to ensure that they meet their environmental obligations. The development of external research links and the formulation of an EMS for locust control have enabled the APLC to identify environmental issues and trends, quantify objective environmental targets and strategies, and facilitate continuous improvement in its environmental performance, while maintaining stakeholder support. This article outlines the environmental issues faced by the APLC, the research programs in place to address these issues, and the procedures in place to incorporate research findings into the organization's operational structure.
The Political Economy of 'Natural' Disasters

Natural disasters occur in a political space. Although events beyond our control may trigger a disaster, the level of government preparedness and response greatly determines the extent of suffering incurred by the affected population. The authors use a political-economy model of disaster prevention, supported by case studies and preliminary empirics, to explain why some governments prepare well for disasters and others do not. The authors show how the presence of international aid distorts this choice and increases the chance that governments will underinvest. Policy suggestions that may alleviate this problem are discussed.
Revised estimates of the risk of fetal loss following a prenatal diagnosis of trisomy 13 or trisomy 18

Edwards syndrome (trisomy 18) and Patau syndrome (trisomy 13) both have high natural fetal loss rates. The aim of this study was to provide estimates of these fetal loss rates by single gestational week of age using data from the National Down Syndrome Cytogenetic Register. Data from all pregnancies with Edwards or Patau syndrome that were prenatally detected in England and Wales from 2004 to 2014 was analyzed using Kaplan‐Meier survival estimates. Pregnancies were entered into the analysis at the time of gestation at diagnosis, and were considered “under observation” until the gestation at outcome. There were 4088 prenatal diagnoses of trisomy 18 and 1471 of trisomy 13 in the analysis. For trisomy 18, 30% (95%CI: 25‐34%) of viable fetuses at 12 weeks will result in a live birth and at 39 weeks gestation 67% (60‐73%) will result in a live birth. For trisomy 13 the survival is 50% (41‐58%) at 12 weeks and 84% (73‐90%) at 39 weeks. There was no significant difference in survival between males and females when diagnosed at 12 weeks for trisomy 18 (P‐value = 0.27) or trisomy 13 (P‐value = 0.47). This paper provides the most precise gestational age‐specific estimates currently available for the risk of fetal loss in trisomy 13 and trisomy 18 pregnancies in a general population.
Enhanced AHS Safety Through the Integration of Vehicle Control and Communication

In fiscal year 2002/2003 we finished the study of the effect of vehicle-vehicle/vehicle-roadside communication on the performance of adaptive cruise control (ACC) systems. Two simulation studies were finished. The first is a single ACC vehicle simulation using MATLAB/SIMULINK. A cut-in scenario and a braking scenario are tested. Communication greatly saves control effort in the former scenario, while it has little effect in the latter. The other work simulates ACC controlled highway merging using SHIFT language. The results show the beneficial effects of communication in terms of the braking effort, the waiting-to-merge queue length, and the main lane traffic shock wave caused by merging.
The Bitter Truth About Sugar and Willpower

The idea behind ego depletion is that willpower draws on a limited mental resource, so that engaging in an act of self-control impairs self-control in subsequent tasks. To present ego depletion as more than a convenient metaphor, some researchers have proposed that glucose is the limited resource that becomes depleted with self-control. However, there have been theoretical challenges to the proposed glucose mechanism, and the experiments that have tested it have found mixed results. We used a new meta-analytic tool, p-curve analysis, to examine the reliability of the evidence from these experiments. We found that the effect sizes reported in this literature are possibly influenced by publication or reporting bias and that, even within studies yielding significant results, the evidential value of this research is weak. In light of these results, and pending further evidence, researchers and policymakers should refrain from drawing any conclusions about the role of glucose in self-control.
Title of Dissertation: On the (Un)intendend Conseq uences of Forgiveness: Creativity After Conflict

Title of Dissertation: On the (Un)intendend Conseq uences of Forgiveness: Creativity After Conflict Ryan Fehr, Ph.D., 2010 Dissertation directed by: Professor Michele J. Gel fand Department of Psychology Within the psychological and organizational scienc es, research on forgiveness as an offender-directed motivational response to victi mization is flourishing. Scholars have drawn from a wide range of theoretical perspectives to better understand the meaning of forgiveness and the antecedents of victims’ forgivi ng motivations. Underlying this research is a near-unanimous assumption that forgiv eness leads to beneficial outcomes, which has paradoxically hampered scholars’ understa nding of the precise nature of those benefits. The purpose of the current research is to consider a previously unforeseen yet broadly significant potential consequence of forgiv eness – creativity. Drawing from evolutionary process models of creative performance (Simonton, 1999; 2003), forgiveness is theorized to impact creativity by br oadening the set of ideas, concepts, and knowledge structures utilized during the creative p rocess, referred to collectively as the participant’s “domain set”. Specifically, forgivene ss and creativity are theoretically linked via three distinct mechanisms: mood, motivat ion, and cognitive resources. Two pilot studies were conducted to ensure the effi cacy of a forgiveness priming procedure and explore a theoretically consistent se t of lab-based creative performance measures. Three primary studies were subsequently c ondu ted to fully test the effect of forgiveness on creative performance and the theoriz d mediating mechanisms. In Study 1, a brainstorming task was utilized to provide ini tial support for the forgivenesscreativity link and the role of domain set over sim ple task persistence. Mood was furthermore measured as a mediating mechanism. Stud y 2 replicated and extended the Study 1 findings via a different creativity task (c reative drawing) and tests of both mood and motivation as potential mediators. In Study 3, further evidence for a forgivenesscreativity effect was sought via a creative problem solving exercise (the Duncker candle task). Mood and motivation were again measured as m ediators. In addition, the cognitive resource theory was explored via the addition of a cognitive load manipulation. Results cumulatively supported the cognitive resource persp ective. In all three studies, forgiveness predicted creative performance. The for giveness-creativity link disappeared under cognitive load (Study 3), but was unrelated t o victim mood (Studies 1-3) or motivation (Studies 2 and 3). In the discussion sec tion, theoretical and practical implications are reviewed along with limitations an d potential future directions. ON THE (UN)INTENDEND CONSEQUENCES OF FORGIVENESS: CREATIVITY AFTER CONFLICT
Cideb Regulates Diet-Induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation

OBJECTIVE—Our previous study suggests that Cidea, a member of Cide family proteins that share sequence homology with the DNA fragmentation factor and are expressed at high levels in brown adipose tissue, plays an important role in the development of obesity. Cideb, another member of Cide family protein, is highly expressed in the liver. We would like to understand the physiological role of Cideb in the regulation of energy expenditure and lipid metabolism. RESEARCH DESIGN AND METHODS—We generated Cideb-null mice by homolog recombination and then fed both wild-type and Cideb-null mice with high-fat diet (58% fat). We then characterized the animals’ adiposity index, food intake, whole-body metabolic rate, liver morphology, rate of fatty acid synthesis and oxidation, insulin sensitivity, and gene expression profile. RESULTS—Cideb-null mice had lower levels of plasma triglycerides and free fatty acids and were resistant to high-fat diet–induced obesity and live steatosis. In addition, Cideb mutant mice displayed significantly increased insulin sensitivity and enhanced rate of whole-body metabolism and hepatic fatty acid oxidation. More importantly, Cideb-null mice showed decreased lipogenesis and reduced expression levels of acetyl-CoA carboxylase, fatty acid synthase, and stearol-CoA desaturase. We further demonstrated that expression levels of sterol response element binding protein 1c was significantly decreased in Cideb-deficient mice. CONCLUSIONS—Our data demonstrate that Cideb is a novel important regulator in lipid metabolism in the liver. Cideb may represent a new therapeutic target for the treatment of obesity, diabetes, and liver steatosis.
ImpAr: A Deterministic Algorithm for Implicit Semantic Role Labelling

This paper presents a novel deterministic algorithm for implicit Semantic Role Labeling. The system exploits a very simple but relevant discursive property, the argument coherence over different instances of a predicate. The algorithm solves the implicit arguments sequentially, exploiting not only explicit but also the implicit arguments previously solved. In addition, we empirically demonstrate that the algorithm obtains very competitive and robust performances with respect to supervised approaches that require large amounts of costly training data.
Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice

The transition from liver fibrosis to hepatocellular carcinoma (HCC) has been suggested to be a continuous and developmental pathological process. MicroRNAs (miRNAs) are recently discovered molecules that regulate the expression of genes involved in liver disease. Many reports demonstrate that miR‐483‐5p and miR‐483‐3p, which originate from miR‐483, are up‐regulated in HCC, and their oncogenic targets have been identified. However, recent studies have suggested that miR‐483‐5p/3p is partially down‐regulated in HCC samples and is down‐regulated in rat liver fibrosis. Therefore, the aberrant expression and function of miR‐483 in liver fibrosis remains elusive. In this study, we demonstrate that overexpression of miR‐483 in vivo inhibits mouse liver fibrosis induced by CCl4. We demonstrate that miR‐483‐5p/3p acts together to target two pro‐fibrosis factors, platelet‐derived growth factor‐β and tissue inhibitor of metalloproteinase 2, which suppress the activation of hepatic stellate cells (HSC) LX‐2. Our work identifies the pathway that regulates liver fibrosis by inhibiting the activation of HSCs.
Abbreviations and Acronyms in English Word-Formation

THIS IS THE FOURTH ARTICLE IN A SERIES about categories of English word-formation-the first three articles treating functional shift, blends, and back-formations (Cannon 1985, 1986; Cannon and Bailey 1986). Collections of abbreviations and acronyms and the considerable scholarship on these two categories will be reviewed, possible solutions to presently untenable definitions and other problems will be offered, and a large corpus of recent items in the two categories will be analyzed. This study has the advantage of drawing on vastly more numerous written data and building on a comprehensive earlier study-Algeo's article (1975), which summarizes the overlapping terminology and the scholarship to that date. This study will update his data and findings, especially in light of the large corpus that we will describe. It will simultaneously update the overall analysis of all 21 categories in Cannon's total 13,683item corpus (1987), and make some comparisons with other categories. The results may shed light on lexicology and lexical theory, the dynamic relations between writing and speech, and the seeming state of the art, as it were, for abbreviations and acronyms.
Effect of Sodium PhÃ©nobarbitaland Sodium Saccharin in AIN-76A Diet on Carcinogenesis Initiated with AL[4-(5-Nitro-2-furyl)-2-thiazolyI]formamide and jY,yV-Dibutylnitrosaminein Male F344 Rats1

Promoting activities of sodium phÃ©nobarbital(PB) and sodium sac charin (SS), incorporated in a semisynthetic diet (AIN-76A), on 2-stage Carcinogenesis initiated with Â¿V-|4-(5-nitro-2-furyl)-2-thiazolyl)formam-ide (FANFT) or yV,/V-dibutylnitrosamine (DBN) in male F344 rats were investigated. For the first 4 weeks of the experiment, weanling male Fischer rats were fed Wayne diet containing 0.2% FANFT or drinking water containing 0.005% DBN. The control rats were given the basal diet and normal drinking water. Beginning at the fifth week, the rats were given the AIN-76A diet or this diet containing 0.05 or 0.15% PB or 5% SS. The experiment was terminated at the end of 100 weeks. PB significantly increased the incidence of transitional cell carcinoma of the bladder of the rats that had been treated with FANFT (P = 0.027). PB also increased the incidence of bladder carcinoma of the rats that had been treated with DBN, but the increase was not significant (P = 0.081). SS in the AIN-76A diet increased the incidence of bladder carcinoma in the rats which had been treated with FANFT or DBN, but the increase was not significant (P = 0.059 and 0.327, respectively). Both high and low doses of PB, but not SS, significantly increased the incidence of hepatocellular carcinoma in the rats that had been treated with DBN. None of the control rats that had been fed the basal diet or the basal diet containing low or high PB or 5% SS developed either bladder or liver carcinoma. These results demonstrate that PB promotes urinary bladder Carcinogenesis of rats initiated with FANFT but not with DBN. In contrast to incorporation in commercial rat chows, SS incorporated in the AIN-76A diet is very weak in promoting bladder Carcinogenesis. On the other hand, PB, but not SS, promotes hepatocarcinogenesis initiated with DBN. Neither PB nor SS promoted DBN-induced Carcinogenesis of esophagus or forestomach.
Increased Prevalence of Autoimmunity and Connective Tissue Diseases in Sickle Cell Disease

Connective tissue disease (CTD) and sickle cell disease (SCD) are diverse group of disorders; however, both of these diseases are characterized by underlying chronic inflammation. CTD is perceived to have a higher incidence and to affect the disease severity in SCD. Objectives: We seek to describe prevalence of autoimmunity and CTD and itsimpact on SCD disease severity as this is not well described in the literature. Methods: We retrospectively reviewed the medical records of 722 patients with SCD, seen over an 11 year period followed at a tertiary care hospital in London, UK. During the last 2 years of the study, number of hospitalizations and length of hospital stay were compared in patients with SCD with and without CTD. Results: In the study cohort, hemoglobin SS was the most common genotype (n = 451; 62%) and 411 (57%) were female. Twenty-three patients (3.1% had documented evidence of CTD, with rheumatoid arthritis (n = 14; 2%) and systemic lupus erythematosus (n = 2; 0.3%) being the most common. Antinuclear antibody was present in 108 (15%) of the patients and anti-smooth muscle antibody was present in 60 (8%). The mean number of hospitalizations (1.9 ± 2.7 vs. 1.5 ± 2.7) and mean length of hospital stay (6 days ± 4.1 vs. 7 days ± 11.4) were not different between those with or without autoimmunity and/or CTD. Avascular necrosis was the most common non-CTD musculoskeletal complication, affecting 72 (10%) patients. Conclusion: Our study suggests that positive autoimmune serology and CTD were more common in SCD compared to non-SCD population of similar ethnic background; however, presence of CTD does not appear to affect the SCD severity. The high frequency of CTD and overlapping of clinical symptoms suggest a need for diagnostic vigilance in diagnosing CTD in patients with SCD.
Idiosyncratic Jobs in Formalized Organizations

Suzanne Estler, James G. March, Jeffrey Pfeffer, W. Richard Scott, Myra Strober, members of the Personnel Office and senior administrators of Stanford University, and many anonymous informants contributed substantially to this research. Valuable assistance in data analysis was provided by W. Burkhardt, Charles Lehner, and Walter Meyers. The following people improved the analysis and reporting of results: Ramon L. Aldag, Randall B. Dunham, Herbert G. Heneman, Ill, John W. Meyer, Gerald R. Salancik, Donald P. Schwab, and two anonymous ASQ reviewers. This research was funded in part by the National Institute for Mental Health, Stanford University, the University of Wisconsin Business School Research Fund, the University of Wisconsin Graduate School, and the Scandinavian Center for Research on Organization Theory. A study of approximately 1,600 job transitions is used to test the assumption made in several organizational literatures that the mix of activities in a job is established in advance of and independent of the characteristics of any particular individual. Based on alternative theories and prior research, the paper defines and measures the occurrence of idiosyncratic jobs whose duties reflect the interests or abilities of current employees (evolved jobs) or others (opportunistic hires). Idiosyncratic jobs account for between 7 and 12 percent of new jobs in a highly formalized system in which such jobs should be least likely to be found. Some theory suggests that such jobs should be harmful, while other theory and field research suggest they may also be the product of benign opportunism by managers in response to ambiguity and uncertainty. This paper identifies six conditions argued to embody such ambiguity and uncertainty and tests the proposition that they enhance the creation rate of idiosyncratic jobs. The results, while modest, support the hypothesis that both types of idiosyncratic jobs occur more frequently when there is change in size and that evolved jobs occur more frequently under conditions of mission ambiguity and resource uncertainty. *
Role of ribosome recycling factor (RRF) in translational coupling

RNA phage GA coat and lysis protein expression are translationally coupled through an overlapping termination and initiation codon UAAUG. Essential for this coupling are the proximity of the termination codon of the upstream coat gene to the initiation codon of the lysis gene (either a <3 nucleotide separation or physical closeness through a possible hairpin structure) but not the Shine–Dalgarno sequence. This suggests that the ribosomes completing the coat gene translation are exclusively responsible for translation of the lysis gene. Inactivation of ribosome recycling factor (RRF), which normally releases ribosomes at the termination codon, did not influence the expression of the reporter gene fused to the lysis gene. This suggests the possibility that RRF may not release ribosomes from the junction UAAUG. However, RRF is essential for correct ribosomal recognition of the AUG codon as the initiation site for the lysis gene.