Miracle-dz/UniFAR-FTUs huggingface dataset:
Radial scars without atypia diagnosed at imaging-guided needle biopsy: how often is associated malignancy found at subsequent surgical excision, and do mammography and sonography predict which lesions are malignant?

OBJECTIVE The purposes of our study were to evaluate the surgical outcome of cases of radial scar without atypia diagnosed at imaging-guided percutaneous needle biopsy and to determine whether the mammographic and sonographic features are able to predict which lesions will be upgraded to malignancy at surgical excision. MATERIALS AND METHODS The records of 4,458 consecutive imaging-guided biopsies were retrospectively reviewed. Surgical excision results were available in 62 cases in which radial scar was the highest-risk lesion at stereotactically guided or sonographically guided biopsy. The mammographic and sonographic images and surgical findings were reviewed. The underestimation rate of malignancy of percutaneous biopsy was calculated. Differences in mammographic and sonographic appearances between radial scars with and without associated malignancy were evaluated using the Fisher's exact test. RESULTS The percutaneous malignancy underestimation rate was 8% (5/62): 9% (4/43) for sonography guided 14-gauge biopsies and 5% (1/19) for stereotactically guided 11-gauge vacuum-assisted biopsies (p = 1.000). Mammographic and sonographic appearances were not significantly different between radial scars with and those without associated malignancy. CONCLUSION A percutaneous diagnosis of a radial scar does not exclude associated malignancy at surgical excision. Mammographic and sonographic features of a lesion diagnosed as a radial scar at percutaneous imaging-guided biopsy do not predict which lesions will have associated malignancy at surgery. Therefore, all patients with percutaneous diagnosis of a radial scar should undergo surgical excision regardless of mammographic and sonographic appearances, until further criteria can be determined.
Molecular and Functional Characterization of the Electroneutral Na/HCO3 Cotransporter NBCn1 in Rat Hippocampal Neurons*

We examined molecular and electrophysiological properties of the electroneutral sodium/bicarbonate cotransporter (NBCn1) that is present in rat hippocampal neurons. By PCR, a deletion variant (NBCn1-E) that lacks 123 amino acids in the cytoplasmic N-terminal domain was found in adult neurons. The previously characterized NBCn1-B, which does not have the deletion, was detected in embryonic neurons. In Xenopus oocytes, NBCn1-E raised the intracellular pH in the presence of HCO3 without significantly affecting the membrane potential. Despite this electroneutral cotransport activity, the transporter mediated a steady-state current that positively shifted the resting potential by almost 30 mV. The mean reversal potential of the steady-state current was –21.2 mV, close to the resting potential of –21.4 mV. The reversal potential shifted 26 mV in response to a 10-fold increase of external Na+ for concentrations above 10 mm. The current activity mediated by the transporter was unaffected by K+, Mg2+, Ca2+, or Cl–. Stable expression of NBCn1-E in human embryonic kidney cells also evoked an inward current that shifted the resting potentials more positive compared with the sham-transfected controls. In primary cultures of embryonic hippocampal neurons, the NBCn1 protein was localized in somatodendrites and synapses. NBCn1 protein was partially colocalized with the postsynaptic density protein PSD-95. Single-cell PCR showed that NBCn1 mRNA expression was present in both γ-aminobutyric acid (GABA)ergic and non-GABAergic neurons. We propose that NBCn1 in hippocampal neurons may affect neuronal activity by regulating local pH as well as steady-state inward currents at synapses.
A classification model for prediction of certification motivations from the contents of ISO 9001 audit reports

ISO 9001 certification motivations can be classified into two main categories: (1) internal motivations; and (2) external motivations. Internal motivations are related with genuine organisational improvement goals (productivity, internal communication, process performance), while external motivations are mainly related to promotional and marketing issues (customer and market pressures, market share). Some companies that become certified mostly upon the basis of external motivations define their main goal as ‘obtaining registration’, and thus typically adopt a limited view over the scope of quality management systems implementation and certification. Based upon a detailed review of 100 ISO 9001 audit reports, we performed a detailed statistical comparison between both types of motivations driving companies in their certification efforts, explored their differences and similarities and derived a statistically based classification model that was able to predict, for a particular organisation, what kind of predominant motivation lead to its certification, from information that can be retrieved from the contents of the corresponding ISO 9001 audit reports.
e‐Government in Jordan: challenges and opportunities

Purpose – The purpose of this paper is to examine the challenges encountered in e‐government implementation, as well as the potential opportunities available in the context of Jordanian society.Design/methodology/approach – A detailed examination and analysis of Jordan's published e‐government vision and strategy is presented, together with a review of other relevant literature.Findings – The findings and implications of this study reveal Jordan is still lagging behind in utilising information and communication technologies for delivering government services online.Practical implications – An understanding of the current status of e‐government in Jordan can help policy makers in the country pursue development of the public sector organisations on the one hand, and would be of importance for Jordan's economic future success on the other.Originality/value – This is believed to be the most up‐to‐date and comprehensive analysis of Jordan's plans and assessment of its level of readiness for delivery of e‐gover.
From ACEA's voluntary agreement to an emission trading scheme for new passenger cars

Abstract This paper critically analyses the voluntary agreement of the European Automobile Manufacturers Association (ACEA) which is intended to ensure a significant reduction of average CO2 emissions from new passenger cars. It concludes that the voluntary agreement is far from being an adequate solution in terms of both ecological effectiveness and economic cost-efficiency. Therefore, the paper proposes to replace the voluntary agreement by an emission trading scheme which directly places car makers under obligation. This switch in policy should be accompanied by further phased increases in the ecotax levied on fuels and a vehicle taxation system that places greater focus on CO2 emission.
Retail assortment, shelf and stockout management : Issues, interplay and future challenges

Starting from a brief literature review, this paper identifies key issues for future research in three related category management (CM) decision areas: assortment, shelf and stockout management. It elaborates on the interdependencies between the three CM issues, underscoring the need for a more integrated research approach. A common framework is presented of factors mediating and moderating consumer reactions to CM changes, which may provide guidelines for future research on reaction heterogeneity. The paper concludes with a discussion of the methodological challenges to be faced, ranging from advanced data collection procedures, over the development of more ingenious model structures, to the design of more powerful estimation and optimization routines. Copyright © 2005 John Wiley & Sons, Ltd.
Developing Metrics for Effective Teaching in Extension Education: A Multi-State Factor-Analytic and Psychometric Analysis of Effective Teaching

To successfully educate the public about agriculture, food, and natural resources, we must have effective educators in both formal and nonformal settings. Specifically, this study, which is a valuable part of a larger sequential mixed-method study addressing effective teaching in formal and nonformal agricultural education, provides direction for future effective teaching research in extension education. Particularly, this study assessed 142 behaviors, characteristics, and techniques considered indicative of effective teaching, to reduce the number of competencies and identify constructs of effective teaching in extension education. A total of 1,470 extension educators from 30 states, surveyed in the fall of 2011, served as the population for this study. As a result, 63 effective teaching competencies in 11 constructs were identified. Psychometric evaluation of the 11 constructs resulted in Cronbach’s alpha coefficients ranging from . 82 to . 93, supporting the reliability of the identified constructs. An expert panel then named the constructs, many of which aligned with those identified in previous teaching effectiveness research. Implications for practice and research resulted from this study, including a proposed three-part framework for assessing effective teaching in extension education, which includes self-evaluation, observation-based assessment, teaching-related output and/or outcome measures.
Community Involvement in Rural Regeneration Partnerships: Exploring the Rural Dimension

This paper is about the involvement of local communities in rural regeneration and area development partnerships. In particular it asks questions about the extent to which there are distinctive rural elements to this which differentiate and counterpoise it to such involvement in urban areas. The paper concludes that, whilst there are some commonalities between such involvement across urban and rural communities, there are also challenges particular to rural areas. These are the spatial features of rural areas, the paucity of human capital in rural communities and a much lower resource level than in urban communities. The paper concludes that these challenges can only be met effectively in rural areas where there is strong local voluntary and community sector infrastructure to support community involvement in rural regeneration partnerships.
Translating obesity: Navigating the front lines of the “war on fat”

Obesity is treated within medicine, public health, and applied sciences as a biomedical fact with urgent health implications; obesity is also, however, a social fact and one that reveals biomedical concerns can lead to social suffering. Translation of social science‐oriented obesity research for broader public good requires navigation of the space between these polemical and seemingly mutually exclusive positions.
Impact of Community Health Funds on the Access to Health Care: Empirical Evidence from Rural Tanzania

Abstract In 1996 the Tanzanian government initiated community health insurance schemes to improve access to health care and to protect people against the financial cost of illness in an environment with shrinking budgets for the health sector. This study aims to evaluate the role of the community-health funds (CHF) in lowering the barriers to assessing health care. Three important results emerge from this study: first, the results show that income is amongst the most important factors determining household participation in the schemes. This means that despite exemption mechanisms, the poorest of the poor within the society are not reached as they can not afford to pay regular insurance premiums. Secondly, though we find no significant differences between members and non-members in the overall amount of health expenditure and in the use of preventive measures, sick individuals in member households were 15 percentage points more likely to get treatment than non-member households. Hence, being insured leads to an increase in the effective utilization of health care. Third, the analysis reveals that members of the CHF are better financially protected against health shocks than non members. The result of this work provides further evidence of the important role that micro-insurance schemes can play in the risk management of people in developing countries.
The Effects of the Image Differentiated Positioning Strategy on Airlines Consumer Behavior: An Application of the Schema Theory

ABSTRACT The purpose of this study is to establish and test a model of the image differentiation positioning strategy in the airline industry. This study is based on the schema, which is defined as “a stored framework of cognitive knowledge that represents information about a topic, a concept, or a particular stimulus, including its attributes and the relations among the attributes” (Aggarwal & McGill, 2007, p. 470). The objectives of the study are: (a) to compare the differences between two models (schema plus tag model and subtyping model) of the schematic process; (b) to identify the relationship between the image differentiated positioning strategy and the schematic process; and (c) to assess how the schematic process influences future consumer behavior (attitude and purchasing behavior). Results showed that the airline's image differentiated positioning strategy had a positive effect on future consumer behavior through the schema.
Mitochondrial dysfunction and respiratory chain defects in a rodent model of methotrexate-induced enteritis

The efficacy of methotrexate (MTX), a widely used chemotherapeutic drug, is limited by its gastrointestinal toxicity and the mechanism of which is not clear. The present study investigates the possible role of mitochondrial damage in MTX-induced enteritis. Small intestinal injury was induced in Wistar rats by the administration of 7 mg kg−1 body wt. MTX intraperitoneally for 3 consecutive days. MTX administration resulted in severe small intestinal injury and extensive damage to enterocyte mitochondria. Respiratory control ratio, the single most useful and reliable test of mitochondrial function, and 3-(4,5-dimethylthiazol-2-yll)-2,5-diphenyltetrazolium bromide reduction, a measure of cell viability were significantly reduced in all the fractions of MTX-treated rat enterocytes. A massive decrease (nearly 70%) in the activities of complexes II and IV was also observed. The results of the present study suggest that MTX-induced damage to enterocyte mitochondria may play a critical role in enteritis. MTX-induced alteration in mitochondrial structure may cause its dysfunction and decreases the activities of the electron chain complexes. MTX-induced mitochondrial damage can result in reduced adenosine triphosphate synthesis, thereby interfering with nutrient absorption and enterocyte renewal. This derangement may contribute to malabsorption of nutrients, diarrhea, and weight loss seen in patients on MTX chemotherapy.
An electromyographic evaluation of dual role breathing and upper body muscles in response to front crawl swimming

The upper body trunk musculature is key in supporting breathing, propulsion, and stabilization during front crawl swimming. The aim of this study was to determine if the latissimus dorsi, pectoralis major, and serratus anterior contributed to the development of inspiratory muscle fatigue observed following front crawl swimming. Fourteen trained swimmers completed a 200‐m front crawl swim at 90% of race pace. Maximal inspiratory and expiratory mouth pressures (PImax and PEmax) were assessed before (baseline) and after each swim, and electromyography was recorded from the three muscles. Post‐swim PImax fell by 11% (P < 0.001, d = 0.57) and the median frequency (MDF: a measure of fatigue) of the latissimus dorsi, pectoralis major, and serratus anterior fell to 90% (P = 0.001, d = 1.57), 87% (P = 0.001, r = −0.60) and 89% (P = 0.018, d = 1.04) of baseline, respectively. The fall in serratus anterior MDF was correlated with breathing frequency (r = 0.675, P = 0.008) and stroke rate (r = 0.639, P = 0.014). The results suggest that the occurrence of inspiratory muscle fatigue was partly caused by fatigue of these muscles, and that breathing frequency and stroke rate particularly affect the serratus anterior.
Work-related musculoskeletal disorders in ultrasound: Can you reduce risk?

Work-related musculoskeletal disorders are a common cause of pain and sickness absence for ultrasound practitioners. This article aims to provide background information about factors increasing the chance of developing work-related musculoskeletal disorders and potential ways to reduce risk. Factors influencing ultrasound professionals’ likelihood of developing work-related musculoskeletal disorders include poor posture, repetitive movements, transducer pressure and poor grip, stress, workload, limited support or sense of control and other psychosocial factors. The impact of these risk factors on the health and well being of ultrasound practitioners can be reduced by following recommendations published by professional bodies and the Health and Safety Executive. Ultrasound practitioners should remember that optimising the examination should not be at the detriment of their health. Some hints and tips to reduce the chance of developing work-related musculoskeletal disorders are provided.
Poplar Wood Rays Are Involved in Seasonal Remodeling of Tree Physiology1[C][W]

Understanding seasonality and longevity is a major challenge in tree biology. In woody species, growth phases and dormancy follow one another consecutively. In the oldest living individuals, the annual cycle may run for more than 1,000 years. So far, however, not much is known about the processes triggering reactivation from dormancy. In this study, we focused on wood rays, which are known to play an important role in tree development. The transition phase from dormancy to flowering in early spring was compared with the phase of active growth in summer. Rays from wood samples of poplar (Populus × canescens) were enriched by laser microdissection, and transcripts were monitored by poplar whole-genome microarrays. The resulting seasonally varying complex expression and metabolite patterns were subjected to pathway analyses. In February, the metabolic pathways related to flower induction were high, indicating that reactivation from dormancy was already taking place at this time of the year. In July, the pathways related to active growth, like lignin biosynthesis, nitrogen assimilation, and defense, were enriched. Based on “marker” genes identified in our pathway analyses, we were able to validate periodical changes in wood samples by quantitative polymerase chain reaction. These studies, and the resulting ray database, provide new insights into the steps underlying the seasonality of poplar trees.
High school physical education: A place to compete not necessarily a place to learn

HIGH SCHOOL PHYSICAL EDUCATION: A PLACE TO COMPETE NOT NECESSARILY A PLACE TO LEARN FEBRUARY 1997 KAREN L. SYKES, B.S., THE PENNSYLVANIA STATE UNIVERSITY Ed.D. , UNIVERSITY OF MASSACHUSETTS AMHERST Directed by: Professor Patt Dodds The purpose of this study was to examine how college freshmen make meaning of their secondary school physical education experiences. The study was also designed to explore the events, individuals or factors associated with their physical education experiences that influenced the ways in which students construct their meanings. Using concepts first identified in Kelly’s (1955) “personal construct psychology”, the study was designed to understand how college students describe their experiences in high school physical education and their current beliefs about the value and meaning of those experiences. A semi-structured, open-ended interview format was used to engage 27 college freshmen from a small private, two year college in New England in a discussion about their high school physical education experiences. This methodology allowed the students/participants to ascribe their own meaning to the experiences they had in physical education. Each audiotaped interview session lasted approximately sixty minutes and was later transcribed for analysis.
Market Reaction and Volatility in the Brazilian Stock Market

We perform an event study to investigate stock returns associated to the announcement of equity issues by Brazilian firms between 1992 and 2003 aiming to determine the market reaction before, during, and after the issue announcement. After measuring abnormal returns by OLS, we used ARCH and GARCH models over 70% of the sample. The results show signs of insider information, negative abnormal returns around the announcement, and persistent negative abnormal returns in the long-term after the issue. The results are consistent with the extant empirical literature and show that ARCH/GARCH estimation of abnormal returns is superior to OLS estimation.
Normal Hepatic Cell Surface Localization of the High Density Lipoprotein Receptor, Scavenger Receptor Class B, Type I, Depends on All Four PDZ Domains of PDZK1*

PDZK1 is a four PDZ domain-containing scaffold protein that binds to scavenger receptor class B, type I (SR-BI), the high density lipoprotein receptor, by its first PDZ domain (PDZ1). PDZK1 knock-out mice exhibit a >95% decrease in hepatic SR-BI protein and consequently an ∼70% increase in plasma cholesterol in abnormally large high density lipoprotein particles. These defects are corrected by hepatic overexpression of full-length PDZK1 but not the PDZ1 domain alone, which partially restores SR-BI protein abundance but not cell surface expression or function. We have generated PDZK1 knock-out mice with hepatic expression of four PDZK1 transgenes encoding proteins with nested C-terminal truncations: pTEM, which lacks the three C-terminal residues (putative PDZ-binding motif), and PDZ1.2, PDZ1.2. 3, or PDZ1.2. 3.4, which contain only the first two, three, or four N-terminal PDZ domains, respectively, but not the remaining C-terminal sequences. Hepatic overexpression of pTEM restored normal hepatic SR-BI abundance, localization, and function. Hepatic overexpression of PDZ1.2 or PDZ1.2. 3 partially restored SR-BI abundance (∼12 or ∼30% of wild type, respectively) but did not (PDZ1.2) or only slightly (PDZ1.2.3) restored hepatic SR-BI cell surface localization and function. Hepatic overexpression of PDZ1.2. 3.4 completely restored SR-BI protein abundance, cell surface expression, and function (normalization of plasma cholesterol levels). Thus, all four PDZ domains in PDZK1, but not PDZ1-3 alone, are sufficient for its normal control of the abundance, localization, and therefore function of hepatic SR-BI, whereas the residues C-terminal to the PDZ4 domain, including the C-terminal putative PDZ-binding domain, are not required.