Miracle-dz/UniFAR-FTUs huggingface dataset:
A 3.5 GHz Spread-Spectrum Clock Generator With a Memoryless Newton-Raphson Modulation Profile

A frequency-locked loop (FLL) based spread-spectrum clock generator (SSCG) with a memoryless Newton-Raphson modulation profile is introduced in this paper. The SSCG uses an FLL as a main clock generator. It brings not only an area reduction to the SSCG but also the advantage of having multiple frequency deviations. A double binary-weighted DAC is proposed that modulates the frequency information of the frequency detector using a 1-1-1 MASH ΔΣ modulator. The Newton-Raphson mathematical algorithm is applied to the proposed profile generator in order to generate the optimized nonlinear profile without needing any memory, resulting in a reduction in the area and the power consumption. It also makes it possible to have multiple modulation frequencies. The SSCG can support 14 frequency deviations of ±0.5% to 3.5% in steps of 0.5% and three modulation frequencies of fm, 2 fm and 3 fm. It achieved an EMI reduction of 19.14 dB with a 0.5% down spreading and a 31 kHz modulation frequency, while employing a core area of 0.076 mm2 in a 0.13-μm CMOS process and consuming 23.72 mW at 3.5 GHz.
Optimal Utilization of Signal-Free Samples for Array Processing in Unknown Colored Noise Fields

Many algorithms for direction-of-arrival (DOA) estimation require the noise covariance matrix to be known or to possess a known structure. In many cases, the noise covariance is, in fact, estimated from separate measurements. This paper addresses the combined effects of finite sample sizes, both in the estimated noise covariance matrix and in the data with signals present. It is assumed that a batch of signal-free samples is available in addition to the signal-containing samples. No assumption is made on the structure of the noise covariance. In this paper, the asymptotic covariance of the weighted subspace fitting (WSF) algorithm is derived for the case in which the data are whitened using an estimated noise covariance. The expression obtained suggests an optimal weighting that improves performance compared to the standard choice. In addition, a new method based on covariance matching is proposed. Both methods are asymptotically statistically efficient. The Cramer-Rao lower bound (CRB) on the covariance of the estimate for the data model is also derived. Monte Carlo simulations show promising small sample performance for the two new methods and confirm the asymptotic results
Visual Servo Regulation of Wheeled Mobile Robots With Simultaneous Depth Identification

In this paper, an adaptive visual servoing scheme is developed to drive a wheeled mobile robot to the desired pose, wherein the unknown depth information is identified simultaneously. Specifically, system errors are selected by measurable signals at first, then the kinematics model is obtained in polar coordinates containing the unknown feature depth. On the basis of the concurrent learning strategy, an augmented adaptive updating law is constructed for the unknown feature depth using both recorded and current data. Then, the regulation controller is designed with polar-coordinate representation to drive the mobile robot to the desired pose under the nonholonomic motion constraint. Subsequently, rigorous stability analysis is conducted by utilizing Lyapunov techniques and LaSalle's invariance principle, demonstrating that the pose regulation errors and the depth identification error can converge to zero simultaneously. The performance of the proposed visual servoing method is further validated by both simulation and experimental results.
Thyroid nodules with highly suspicious ultrasonographic features, but with benign cytology on two occasions: is malignancy still possible?

ABSTRACT Objective There is no information about the frequency of malignancy specifically in the case of thyroid nodules with highly suspicious sonographic features, but with two fine needle aspiration (FNA) showing benign cytology. This was the objective of the study. Subjects and methods We report the results of 105 patients with thyroid nodules considered “highly suspicious” according to the ultrasonographic classification of American Thyroid Association, in whom FNA revealed benign cytology on two occasions (interval of 6 months). Results Thyroidectomy was performed in 11 cases due to desire of the patient or significant growth of the nodule. In these patients, cytology continued to be benign in 9, was non-diagnostic in 1, and suspicious in 1. Histology revealed papillary carcinoma in only one nodule. In patients in whom a third FNA was obtained for this study (n = 94), cytology continued to be benign in 86, became non-diagnostic in 5, indeterminate in 2, and suspicious in 1. The last 8 patients (with non-benign cytology) were submitted to thyroidectomy and histology revealed malignancy in only one nodule. Conclusion The rate of malignancy found here for nodules with highly suspicious sonographic features, even after two FNA showing benign cytology, was 2%. We believe that in these cases, the continuation of follow-up consisting of ultrasound at intervals of 2 years may still be adequate.
On Redundancy in Linked Geospatial Data

RCC8 is a constraint language that serves for qualitative spatial representation and reasoning by encoding the topological relations between spatial entities. As such, RCC8 has been recently adopted by GeoSPARQL in an effort to enrich the Semantic Web with qualitative spatial relations. We focus on the redundancy that these data might harbor, which can throttle graph related applications, such as storing, representing, querying, and reasoning. For a RCC8 network N a constraint is redundant, if removing that constraint from N does not change the solution set of N . A prime network of N is a network which contains no redundant constraints, but has the same solution set as N . In this paper, we present a practical approach for obtaining the prime networks of RCC8 networks that originate from the Semantic Web, by exploiting the sparse and loosely connected structure of their constraint graphs, and, consequently, contribute towards offering Linked Geospatial Data of high quality. Experimental evaluation exhibits a vast decrease in the total number of non-redundant constraints that we can obtain from an initial network, while it also suggests that our approach significantly boosts the state-of-the-art approach.
MT-CGP: mixed type cartesian genetic programming

The majority of genetic programming implementations build expressions that only use a single data type. This is in contrast to human engineered programs that typically make use of multiple data types, as this provides the ability to express solutions in a more natural fashion. In this paper, we present a version of Cartesian Genetic Programming that handles multiple data types. We demonstrate that this allows evolution to quickly find competitive, compact, and human readable solutions on multiple classification tasks.
GABA Predicts Time Perception

Our perception of time constrains our experience of the world and exerts a pivotal influence over a myriad array of cognitive and motor functions. There is emerging evidence that the perceived duration of subsecond intervals is driven by sensory-specific neural activity in human and nonhuman animals, but the mechanisms underlying individual differences in time perception remain elusive. We tested the hypothesis that elevated visual cortex GABA impairs the coding of particular visual stimuli, resulting in a dampening of visual processing and concomitant positive time-order error (relative underestimation) in the perceived duration of subsecond visual intervals. Participants completed psychophysical tasks measuring visual interval discrimination and temporal reproduction and we measured in vivo resting state GABA in visual cortex using magnetic resonance spectroscopy. Time-order error selectively correlated with GABA concentrations in visual cortex, with elevated GABA associated with a rightward horizontal shift in psychometric functions, reflecting a positive time-order error (relative underestimation). These results demonstrate anatomical, neurochemical, and task specificity and suggest that visual cortex GABA contributes to individual differences in time perception.
Histopathological findings in goiter: A review of 624 thyroidectomies.

OBJECTIVES To identify the histopathological patterns of goiter in thyroidectomy specimens and their frequency in relation to age and gender of the patients. METHODOLOGY We present a retrospective data of 624 thyroidectomy specimens diagnosed over a period of six year (2007-2012) at the Department of Pathology, Holy Family Hospital, Rawalpindi, Pakistan. RESULTS A total of 624 consecutive thyroidectomy specimens were selected. Patient's age ranges from 11-89 years, 541 females and 83 males. There were 512 (82%) non-neoplastic lesions, which includes; 475 (76.1%) multi-nodular goiter (MNG), 16 (2.6%) Hashimoto thyroiditis, 11 (1.8%) colloid goiter, 4 (0.6%) toxic goiter, 2 (0.3%) chronic lymphocytic thyroiditis, 2 (0.3%) tuberculous thyroiditis and 2 (0.3%) miscellaneous. From 112 (18%) neoplastic lesions, 43 (6.9%) were adenomas (41 females and 2 males) and 69 (11.0%) were carcinomas (58 females and 11 males). Peak age for thyroid malignancy was 3rd to 4th decades. The histological subtypes of thyroid carcinomas includes, 35 (5.6%) follicular variant of papillary carcinoma (FVPC), 15 (2.5%) well-differentiated tumor of uncertain malignant potential (WDT-UMP), 6 (1%) medullary carcinomas, 6 (1%) papillary carcinomas, 3 (0.5%) anaplastic carcinomas, 2 (0.3%) follicular carcinomas and 2 (0.3%) other carcinomas. Twenty-nine (4.6%) neoplastic lesions were associated with MNG, includes; 2 (3.5%) follicular adenomas, 3 (0.5%) WDT-UMP and 4 (0.6%) FVPC. CONCLUSIONS MNG is common and FVPC is the common thyroid cancer seen in females. The overall frequency of thyroid cancer is 11%. Follicular adenoma and FVPC appears to be associated with long standing MNG of iodine deficiency.
Neisseria gonorrhoeae requires expression of TonB and the putative transporter TdfF to replicate within cervical epithelial cells

Neisseria gonorrhoeae has evolved a repertoire of iron acquisition systems that facilitate essential iron uptake in the human host. Acquisition of iron requires both the energy‐harnessing cytoplasmic membrane protein, TonB, as well as specific outer membrane TonB‐dependent transporters (TdTs.) Survival within host epithelial cells is important to the pathogenesis of gonococcal disease and may contribute to the persistence of infection. However, the mechanisms by which gonococci acquire iron within this intracellular niche are not currently understood. In this study, we investigated the survival of gonococcal strain FA1090 within ME180 human cervical epithelial cells with respect to high affinity iron acquisition. Intracellular survival was dependent upon iron supplied by the host cell. TonB was expressed in the host cell environment and this protein was critical to gonococcal intracellular survival. Furthermore, expression of the characterized outer membrane transporters TbpA, FetA and LbpA and putative transporters TdfG, TdfH and TdfJ were not necessary for intracellular survival. Conversely, intracellular survival was dependent on expression of the putative transporter, TdfF. Expression of TdfF was detected in the presence of epithelial cell culture media containing fetal bovine serum. Expression was further modulated by iron availability. To our knowledge, this study is the first to demonstrate the specific requirement for a single iron transporter in the survival of a bacterial pathogen within host epithelial cells.
The predictive value of prostate cancer biomarkers depends on age and time to diagnosis: Towards a biologically‐based screening strategy

Both benign and malignant prostate diseases elevate total prostate‐specific antigen (tPSA), and the incidence of benign disease increases markedly with age. There is evidence, however, that free‐to‐total PSA ratio (%fPSA) and human kallikrein 2 (hK2) more closely reflect the malignant process. We tested the hypothesis that tPSA levels are more strongly predictive of cancer in younger when compared to older men, whereas %fPSA and hK2 are more strongly predictive in men tested closer to diagnosis. The study included 13,676 men age ≥ 44 in Sweden, where PSA screening was uncommon during the study period. fPSA, tPSA and hK2 were measured in archived plasma collected during 1974–1986 in 501 men subsequently diagnosed with prostate cancer up to 1999 and in 1,292 matched controls. The predictive value of tPSA was lower in older men (p = 0.003) but was not strongly affected by time to diagnosis (p = 0.3); the predictive value of hK2 was higher closer to diagnosis (p < 0.0005) but was not modified by age (p = 0.7). A model including tPSA, fPSA and hK2 was superior (p = 0.02) to tPSA alone in older (AUC 0.819 vs. 0.794), but not in younger men (0.758 vs. 0.759). Total PSA can be used as a single marker at early middle age to predict long‐term risk of prostate cancer and thus to determine intensity of subsequent screening. In contrast, %fPSA and hK2 add important predictive value in older men and much closer to diagnosis. Strategies for prostate cancer screening should be based on thorough understanding of the interaction of kallikrein‐related biomarkers with prostate pathobiology. © 2007 Wiley‐Liss, Inc.
Family decision-making in advanced dementia: narrative and ethics.

BACKGROUND Traditionally, family members become decision-makers for ageing parents with cognitive impairment. Our understanding of how families negotiate the ethical issues in this decision-making is still developing. AIM To describe and understand the ethical thinking used in end-of-life decision-making by family surrogates on behalf of their cognitively impaired elders. METHODS Qualitative research with eight focus groups that included 39 family members of severely impaired nursing home residents in Minnesota. Transcripts were analysed using a thematic approach. FINDINGS The family surrogates described their decision-making as a process based in the families' stories and as extensions of the elders' identities. Four themes emerged from the analysis of the families' decision-making: (i) acquisition of decision-making authority, (ii) decision-making for short-term or long-term time frames, (iii) justifying the decisions and (iv) advocacy for the elders. CONCLUSIONS The families in these focus groups used the elders' life stories to frame their decisions for care. Providers working in primary care settings who work with families in making care decisions for cognitively impaired elderly patients may find narrative ethics more pertinent than principle-based ethics in understanding families' perspectives and priorities, while also recognizing their decision-making transition from using the principle of autonomy to that of beneficence.
Pruebas de bondad de ajuste en distribuciones simétricas, ¿qué estadístico utilizar?

The use of nonparametric tests is recommended when the data do not meet the assumptions of normality and homoscedasticity. However, the assumptions of normality of the data or the use of goodness of fit tests that are not appropriate for the assessed sample are common aspects. In many cases, this implies the use of statistical tests unadjusted for the real data distribution and, consequently, the establishment of inaccurate conclusions. Therefore, in this paper the detection power of five tests of goodness of fit (Kolmogorov-Smirnov-Lilliefors, Kolmogorov-Smirnov, Shapiro-Wilk, Anderson-Darling and Jarque-Bera) in symmetric distributions is analysed in six sample sizes between 30 and 1000 participants generated by Monte Carlo simulation. Results show a marked conservative tendency as the sample size becomes larger. Regarding sample sizes to detect non-normality: analysing small samples the best results are provided by Kolmogorov-Smirnov-Lilliefors and Anderson-Darling tests, if the sample is medium-sized (200 participants) the Kolmogorov-Smirnov, and when samples are over 500 participants the Shapiro-Wilk test is recommended. In addition, the classic test of Kolmogorov-Smirnov is considered absolutely ineffective regardless the sample size.
That's Near My Hand! Parietal and Premotor Coding of Hand-Centered Space Contributes to Localization and Self-Attribution of the Hand

The ability to identify and localize our own limbs is crucial for survival. Indeed, the majority of our interactions with objects occur within the space surrounding the hands. In non-human primates, neurons in the posterior parietal and premotor cortices dynamically represent the space near the upper limbs in hand-centered coordinates. Neuronal populations selective for the space near the hand also exist in humans. It is unclear whether these remap the peri-hand representation as the arm is moved in space. Furthermore, no combined neuronal and behavioral data are available about the possible involvement of peri-hand neurons in the perception of the upper limbs in any species. We used fMRI adaptation to demonstrate dynamic hand-centered encoding of space by reporting response suppression in human premotor and posterior parietal cortices to repeated presentations of an object near the hand for different arm postures. Furthermore, we show that such spatial representation is related to changes in body perception, being remapped onto a prosthetic hand if perceived as one's own during an illusion. Interestingly, our results further suggest that peri-hand space remapping in the premotor cortex is most tightly linked to the subjective feeling of ownership of the seen limb, whereas remapping in the posterior parietal cortex closely reflects changes in the position sense of the arm. These findings identify the neural bases for dynamic hand-centered encoding of peripersonal space in humans and provide hitherto missing evidence for the link between the peri-hand representation of space and the perceived self-attribution and position of the upper limb.
Different Subtypes of Striatal Neurons Are Selectively Modulated by Cortical Oscillations

The striatum is the key site for cortical input to the basal ganglia. Cortical input to striatal microcircuits has been previously studied only in the context of one or two types of neurons. Here, we provide the first description of four putative types of striatal neurons (medium spiny, fast spiking, tonically active, and low-threshold spiking) in a single data set by separating extracellular recordings of sorted single spikes recorded under halothane anesthesia using waveform and burst parameters. Under halothane, the electrocorticograms and striatal local field potential displayed spontaneous oscillations at both low (2–9 Hz) and high (35–80 Hz) frequencies. Putative fast spiking interneurons were significantly more likely to phase lock to high-frequency cortical oscillations and displayed significant cross-correlations in this frequency range. These findings suggest that, as in neocortex and hippocampus, the coordinated activity of fast spiking interneurons may specifically be involved in mediating oscillatory synchronization in the striatum.
Morphogenetic Plasticity of Neuronal Elements in Cerebellar Glomeruli during Deafferentation-Induced Synaptic Reorganization

Reorganization of the cerebellar glomerulus, the main synaptic complex within the granule cell layer, was investigated using quantitative morphological techniques. All afferents to the cerebellar cortex, including mossy-fibers, were surgically destroyed by undercutting the cerebellar vermis. Fifteen days after the operation, which resulted in the removal of the main excitatory afferent to the glomerulus, a significant reorganization of the whole synaptic complex was observed, whereas the structural integrity of the glomerulus was remarkably well preserved. This was indicated by the observation that the number of granule cell dendrites (≈50 per glomerulus), as well as the number of dendritic digits (≈210 per glomerulus) bearing most of the ≈230 synaptic junctions per glomerulus, did not change significantly after mossy-fiber degeneration. The total number of synapses in the reorganized glomerulus did not change either, despite the disappearance of two-thirds of (excitatory) synaptic junctions caused by mossy-fiber degeneration. In the reorganized glomeruli, however, the inhibitory, GABA-containing Golgi axonal varicosities became the dominant synaptic type—about four-fifths (≈200) of all synapses within the glomerulus—whereas the dendritic synapses between the granule cells represented only one-fifth of all synaptic junctions. The quantitative data of the reorganized cerebellar glomerulus demonstrate both a remarkable constancy and a plasticity of he excitatory granule cells and inhibitory Golgi neurons building up this synaptic complex. constancy (the preservation of certain specific structural features) is represented by an eventually unchanged number of dendrites and synaptic junctions within the deafferented lomerulus. Such constancy was made possible, however, by the morphogenetic plasticity of both nerve-cell types to produce new, dendrodendritic and axo-dendritic synapses to compensate for the loss of mossy-fiber synapses.
Financial Firm Bankruptcy and Contagion

The Lehman bankruptcy highlights the potential for interconnectedness to cause negative externalities through counterparty contagion, but the externalities may also arise from information contagion. We examine contagion from troubled financial firms and find that counterparty contagion is greater during recessions and in cases of riskier firms and larger and more complex exposures. However, the counterparty exposures are small, especially among banks that face diversification regulations, and do not typically cause a cascade of failures. Information contagion is stronger for rivals in the same locale or the same line of business and is stronger in cases of distress than in bankruptcies.
Sleep Disturbances Associated with Parkinson's Disease

Sleep disturbances are common problems affecting the quality life of Parkinson's disease (PD) patients and are often underestimated. The causes of sleep disturbances are multifactorial and include nocturnal motor disturbances, nocturia, depressive symptoms, and medication use. Comorbidity of PD with sleep apnea syndrome, restless legs syndrome, rapid eye movement sleep behavior disorder, or circadian cycle disruption also results in impaired sleep. In addition, the involvement of serotoninergic, noradrenergic, and cholinergic neurons in the brainstem as a disease-related change contributes to impaired sleep structures. Excessive daytime sleepiness is not only secondary to nocturnal disturbances or dopaminergic medication but may also be due to independent mechanisms related to impairments in ascending arousal system and the orexin system. Notably, several recent lines of evidence suggest a strong link between rapid eye movement sleep behavior disorder and the risk of neurodegenerative diseases such as PD. In the present paper, we review the current literature concerning sleep disorders in PD.
Epistemic Actions in Science Museums: Families Interacting with the Mirror Room Exhibit

Interactive museum exhibits offer opportunities to manipulate and discuss phenomena. Epistemic actions relevant to the Mirror Room exhibit were identified, analyzing the exhibit’s messages and the external representations that support these activities. Exhibit elements were placed at different angles to support the conversation around the number of reflections in each corner. The effect of these external representations on the interaction of families in the Mirror Room was recorded. Geometric solids in the corners of the mirrors in the experimental group doubled the interaction time and supported epistemic actions (e. g. counting) as compared to the control group without the geometric solids. In addition, families mentioned corners or angles more frequently in the experimental situation. Based on these results, it is recommended to implement a representational analysis for the identification of specific epistemic actions in each exhibit as design guidelines.