Miracle-dz/UniFAR-FTUs huggingface dataset:
The Metabolic Fate of Deoxynivalenol and Its Acetylated Derivatives in a Wheat Suspension Culture: Identification and Detection of DON-15-O-Glucoside, 15-Acetyl-DON-3-O-Glucoside and 15-Acetyl-DON-3-Sulfate

Deoxynivalenol (DON) is a protein synthesis inhibitor produced by the Fusarium species, which frequently contaminates grains used for human or animal consumption. We treated a wheat suspension culture with DON or one of its acetylated derivatives, 3-acetyl-DON (3-ADON), 15-acetyl-DON (15-ADON) and 3,15-diacetyl-DON (3,15-diADON), and monitored the metabolization over a course of 96 h. Supernatant and cell extract samples were analyzed using a tailored LC-MS/MS method for the quantification of DON metabolites. We report the formation of tentatively identified DON-15-O-β-D-glucoside (D15G) and of 15-acetyl-DON-3-sulfate (15-ADON3S) as novel deoxynivalenol metabolites in wheat. Furthermore, we found that the recently identified 15-acetyl-DON-3-O-β-D-glucoside (15-ADON3G) is the major metabolite produced after 15-ADON challenge. 3-ADON treatment led to a higher intracellular content of toxic metabolites after six hours compared to all other treatments. 3-ADON was exclusively metabolized into DON before phase II reactions occurred. In contrast, we found that 15-ADON was directly converted into 15-ADON3G and 15-ADON3S in addition to metabolization into deoxynivalenol-3-O-β-D-glucoside (D3G). This study highlights significant differences in the metabolization of DON and its acetylated derivatives.
Room-Temperature Electroluminescence From GeSn Light-Emitting Pin Diodes on Si

In this letter, a GeSn light-emitting pin diode integrated on Si via a Ge buffer is demonstrated and it is compared with a light-emitting pin diode made from pure, unstrained Ge on Si. The diode layer structures are grown with a special low-temperature molecular beam epitaxy process. The pseudomorphic GeSn layers (1.1% Sn content) on the Ge buffer are compressively strained. Both light-emitting pin diodes clearly show direct bandgap electroluminescence emission at room temperature. The electroluminescence peak of the GeSn light-emitting pin diode is shifted by 20 meV into the infrared region compared to the electroluminescence peak of the unstrained Ge light-emitting pin diode. The shift is due to the lower bandgap of GeSn and the influence of strain.
Towards a Revival of Indigenous Mobility in French Guiana? Contemporary Transformations of the Wayãpi and Teko Territories

The goal of this article is to understand the contemporary transformations of indigenous territories in relation to several factors, including urbanisation, population growth, economic development and conservation policies. Using socio-economic, governance and land use data, we explain the current territorial reorganisations of the Wayapi and Teko indigenous peoples. We demonstrate the existence of an emerging ‘multi-sited’ land use system that allows these indigenous peoples to benefit from resources in both urban and forest areas and ensures sovereignty over the territory. We emphasise the role of the delimitation of protected areas in catalysing identity claims and the process of land use reformulation.
Real-parameter optimization using the mutation step co-evolution

An evolutionary algorithm for the optimization of a function with real parameters is described in this paper. It uses a cooperative co-evolution to breed and reproduce successful mutation steps. The algorithm described herein is then tested on a suite of 10D and 30D reference optimization problems collected for the special session on real-parameter optimization of the IEEE Congress on Evolutionary Computation 2005. The results are of mixed quality (as expected), but reveal several interesting aspects of this simple algorithm
Anticardiolipin antibodies in Behçet's disease: a reassessment.

OBJECTIVE To assess the frequency and clinical relevance of anticardiolipin antibodies (aCL) in Behçet's disease (BD). METHODS IgG, IgM and IgA aCL isotypes were investigated by ELISA in 128 patients with BD, 143 healthy controls and 20 systemic lupus erythematosus (SLE) patients. RESULTS The IgA binding index (BI) was slightly elevated in BD compared with healthy controls (120+/-53 vs 107+/-46, P=0.02), whereas IgG and IgM aCL levels were not significantly different (IgG, BD 2.5+/-2.4 G phospholipid (GPL), healthy controls 2.8+/-3.6 GPL, P=0.6; IgM, BD 0.7+/-0.9 M phospholipid (MPL), healthy controls 0.9+/-1.3 MPL, P=0.6). The frequency of aCL positivity was 7% in BD (IgG 0.8%, IgM 1.6%, IgA 4.6%), 50% in SLE and 5.6% in healthy controls. IgA BI was elevated in the HLA-B5-negative group compared with HLA-B5-positive patients (P<0.005). In a literature review, the frequency of aCL was found to be 9.5% in studies from Turkey compared with 25.5% in other series (P<0.0001). CONCLUSION These results do not suggest a primary role for aCL in BD. A significantly lower frequency of aCL in Turkish BD patients than in other series indicate that regional determinants, whether environmental or genetic, might also play a role in controlling aCL production in BD.
Quality Analysis of Chlorogenic Acid and Hyperoside in Crataegi fructus

Background: Crataegi fructus is a herbal medicine for strong stomach, sterilization, and alcohol detoxification. Chlorogenic acid and hyperoside are the major compounds in Crataegi fructus. Objective: In this study, we established novel high-performance liquid chromatography (HPLC)-diode array detection analysis method of chlorogenic acid and hyperoside for quality control of Crataegi fructus. Materials and Methods: HPLC analysis was achieved on a reverse-phase C18 column (5 μm, 4.6 mm × 250 mm) using water and acetonitrile as mobile phase with gradient system. The method was validated for linearity, precision, and accuracy. About 31 batches of Crataegi fructus samples collected from Korea and China were analyzed by using HPLC fingerprint of developed HPLC method. Then, the contents of chlorogenic acid and hyperoside were compared for quality evaluation of Crataegi fructus. Results: The results have shown that the average contents (w/w %) of chlorogenic acid and hyperoside in Crataegi fructus collected from Korea were 0.0438% and 0.0416%, respectively, and the average contents (w/w %) of 0.0399% and 0.0325%, respectively. Conclusion: In conclusion, established HPLC analysis method was stable and could provide efficient quality evaluation for monitoring of commercial Crataegi fructus.
Micromechanical Modeling of Fiber Composites Under Off-Axis Loading

The nonlinear behavior of AS4/PEEK composite under off-axis loading was investigated using a finite element-based micromechanical approach with three different unit cells. Proper boundary conditions for uniaxial off-axis loading for the unit cell were established. The elastic moduli of the fiber and the nonlinear stress-strain curve of the matrix were used in the micromechanical analysis. By comparing the predicted off-axis stress-strain curves with experimental data, it was found that the nonlinear behavior of the composite is highly dependent on the fiber packing arrangement of the unit cell model.
Light penetration structures the deep acoustic scattering layers in the global ocean

The depth distribution of a major marine biomass component is determined by variation in water clarity. The deep scattering layer (DSL) is a ubiquitous acoustic signature found across all oceans and arguably the dominant feature structuring the pelagic open ocean ecosystem. It is formed by mesopelagic fishes and pelagic invertebrates. The DSL animals are an important food source for marine megafauna and contribute to the biological carbon pump through the active flux of organic carbon transported in their daily vertical migrations. They occupy depths from 200 to 1000 m at daytime and migrate to a varying degree into surface waters at nighttime. Their daytime depth, which determines the migration amplitude, varies across the global ocean in concert with water mass properties, in particular the oxygen regime, but the causal underpinning of these correlations has been unclear. We present evidence that the broad variability in the oceanic DSL daytime depth observed during the Malaspina 2010 Circumnavigation Expedition is governed by variation in light penetration. We find that the DSL depth distribution conforms to a common optical depth layer across the global ocean and that a correlation between dissolved oxygen and light penetration provides a parsimonious explanation for the association of shallow DSL distributions with hypoxic waters. In enhancing understanding of this phenomenon, our results should improve the ability to predict and model the dynamics of one of the largest animal biomass components on earth, with key roles in the oceanic biological carbon pump and food web.
Salience network dynamics underlying successful resistance of temptation

Self-control and the ability to resist temptation are critical for successful completion of long-term goals. Contemporary models in cognitive neuroscience emphasize the primary role of prefrontal cognitive control networks in aligning behavior with such goals. Here we use gaze pattern analysis and dynamic functional connectivity fMRI data to explore how individual differences in the ability to resist temptation are related to intrinsic brain dynamics of the cognitive control and salience networks. Behaviorally, individuals exhibit greater gaze distance from target location (e.g. higher distractibility) during presentation of tempting erotic images compared with neutral images. Individuals whose intrinsic dynamic functional connectivity patterns gravitate towards configurations in which salience detection systems are less strongly coupled with visual systems resist tempting distractors more effectively. The ability to resist tempting distractors was not significantly related to intrinsic dynamics of the cognitive control network. These results suggest that susceptibility to temptation is governed in part by individual differences in salience network dynamics, and provide novel evidence for involvement of brain systems outside canonical cognitive control networks in contributing to individual differences in self-control.
Oogenesis and reproductive investment of Atlantic herring are functions of not only present but long-ago environmental influences as well

Significance Fish stock advice and management have a focus on protecting the reproductive capacity of a stock. Central to the associated research undertaken is whether spawning stock biomass is a proxy for total egg production. Here we demonstrate for the planktivorous Atlantic herring that the standard use of season-independent potential fecundity formulas may cause flaws in these interpretations. In particular, this would happen when the adults have experienced poor feeding conditions that negatively affect the reservoir of primary oocytes and thereby the future fecundity. Hence, females in excellent condition may show significantly lower-than-expected fecundity that could lead to errors in the judgment of reproductive capacity, especially under “red flag” situations. Following general life history theory, immediate reproductive investment (egg mass × fecundity/body mass) in oviparous teleosts is a consequence of both present and past environmental influences. This clarification questions the frequent use of season-independent (general) fecundity formulas in marine fish recruitment studies based on body metrics only. Here we test the underlying assumption of no lag effect on gametogenesis in the planktivorous, determinate-fecundity Atlantic herring (Clupea harengus) displaying large plasticity in egg mass and fecundity, examining Norwegian summer–autumn spawning herring (NASH), North Sea autumn-spawning herring (NSAH), and Norwegian spring-spawning herring (NSSH). No prior reproductive information existed for NASH. Compared with the 1960s, recent reproductive investment had dropped markedly, especially for NSAH, likely reflecting long-term changes in zooplankton biography and productivity. As egg mass was characteristically small for autumn spawners, although large for spring spawners (cf. different larval feeding conditions), fecundity was the most dynamic factor within reproductive investment. For the data-rich NSSH, we showed evidence that transient, major declines in zooplankton abundance resulted in low fecundity over several subsequent seasons, even if Fulton’s condition factor (K) turned high. Temporal trends in Kslope (K on total length) were, however, informative. These results clarify that fecundity is defined by (i) dynamics of primary (standing stock) oocytes and (ii) down-regulation of secondary oocytes, both processes intimately linked to environmental conditions but operating at different timescales. Thus, general fecundity formulas typically understate interannual variability in actual fecundity. We therefore argue for the use of segmented fecundity formulas linked to dedicated monitoring programs.
A Structural Materials: Properties, Microstructure and Processing.

Abstract : The journal provides an international medium for the publication of theoretical and experimental studies and reviews of the properties and behavior of a wide range of materials, related both to their structure and to their engineering application. The varied topics comprising materials science and engineering are viewed as appropriate for publication: these include, but are not limited to, the properties and structure of crystalline and non-crystalline metals and ceramics, polymers and composite materials. (MM)
The use of gallium-67 scintigraphy in the diagnosis of acute interstitial nephritis

Background Gallium-67 scintigraphy has been suggested as a noninvasive method to diagnose acute interstitial nephritis (AIN). However, its diagnostic performance and usefulness remain controversial. Methods We retrospectively reviewed the charts of 76 patients who underwent gallium-67 scintigraphy for a suspicion of AIN. Patients were classified based on kidney biopsy and/or clinical probability of AIN. Gallium-67 scintigraphy results were reinterpreted blindly using both posterior planar and single photon emission computed tomography (SPECT) imaging. Intensity of radioisotope uptake in the kidney was graded from 0 to 5. Results The diagnosis of AIN was confirmed in 23 patients and excluded in 44. Nine patients with an uncertain diagnosis were excluded from subsequent analysis. A gallium-67 kidney uptake cutoff of 1 gave a negative predictive value of 100%, whereas a cutoff of 5 had an excellent specificity and positive predictive value for the diagnosis of AIN. When using a cutoff of 3, which had previously been used in the literature, we obtained a sensitivity of 61% and a specificity of 75% with posterior planar imaging. The results of both SPECT and posterior planar imaging modalities were comparable. Conclusions Gallium-67 scintigraphy may be of interest in patients with a clinical suspicion of AIN, especially in those who are unable to undergo kidney biopsy. However, results need to be interpreted with caution and depend on the intensity of gallium-67 kidney uptake.
Generation of the membrane potential and its impact on the motility, ATP production and growth in Campylobacter jejuni

The generation of a membrane potential (Δψ), the major constituent of the proton motive force (pmf), is crucial for ATP synthesis, transport of nutrients and flagellar rotation. Campylobacter jejuni harbors a branched electron transport chain, enabling respiration with different electron donors and acceptors. Here, we demonstrate that a relatively high Δψ is only generated in the presence of either formate as electron donor or oxygen as electron acceptor, in combination with an acceptor/donor respectively. We show the necessity of the pmf for motility and growth of C. jejuni. ATP generation is not only accomplished by oxidative phosphorylation via the pmf, but also by substrate‐level phosphorylation via the enzyme AckA. In response to a low oxygen tension, C. jejuni increases the transcription and activity of the donor complexes formate dehydrogenase (FdhABC) and hydrogenase (HydABCD) as well as the transcription of the alternative respiratory acceptor complexes. Our findings suggest that in the gut of warm‐blooded animals, C. jejuni depends on at least formate or hydrogen as donor (in the anaerobic lumen) or oxygen as acceptor (near the epithelial cells) to generate a pmf that sustains efficient motility and growth for colonization and pathogenesis.
Serum- and Glucocorticoid-Regulated Kinase (SGK1) Gene and Blood Pressure

The serum- and glucose-regulated kinase (SGK1) gene has recently been identified as an important aldosterone-induced protein kinase that mediates trafficking of the renal epithelial Na+ channel (ENaC) to the cell membrane. Thus, SGK1 is an appealing candidate for blood pressure regulation and possibly essential hypertension. To test this hypothesis, we recruited monozygotic (126 pairs) and dizygotic (70 pairs) normotensive twin subjects and parents of dizygotic twins. Blood pressure was measured in a controlled fashion: recumbent, sitting, and upright. We documented genetic variance on blood pressure in all positions. We then relied on microsatellite markers at the SGK1 gene locus (D6S472, D6S1038, and D6S270) and 2 single nucleotide polymorphisms within the SGK1 gene. We found significant linkage of the SGK1 gene locus to diastolic blood pressure (P <0.0002) and suggestive evidence for linkage for systolic blood pressure (P <0.04), documenting the locus as a quantitative trait locus for blood pressure. We next performed association, using all dizygotic twins and a monozygotic member from each pair. We found significant associations between both single nucleotide polymorphism variants and blood pressure, as well as a significant interaction between the single nucleotide polymorphisms enhancing the effect. This combined effect of the polymorphisms was confirmed in an independent sample of 260 young normotensive men. We conclude that the SGK1 gene is relevant to blood pressure regulation and probably to hypertension in man.
Dynamics and solutions to some control problems for water-tank systems

We consider a tank containing a fluid. The tank is subjected to directly controlled translations and rotations. The fluid motion is described by linearized wave equations under shallow water approximations. For irrotational flows, a new variational formulation of Saint-Venant equations is proposed. This provides a simple method to establish the equations when the tank is moving. Several control configurations are studied: one and two horizontal dimensions; tank geometries (straight and nonstraight bottom, rectangular and circular shapes), tank motions (horizontal translations with and without rotations). For each configuration, we prove that the linear approximation is steady-state controllable and provide a simple and flatness-based algorithm for computing the steering open-loop control. These algorithms rely on operational calculus. They lead to second order equations in space variables whose fundamental solutions define delay operators corresponding to convolutions with compact support kernels. For each configuration, several controllability open-problems are proposed and motivated.
Impact of periconceptional multi-micronutrient supplementation on gestation: a population-based study.

OBJECTIVE To examine the effect of periconceptional multi-micronutrient supplementation on gestation and birth outcomes. METHODS A population-based community intervention program was conducted in 18 counties in China. Participants were divided into an intervention group, who received multi-micronutrient supplementation from at least 3 months before pregnancy throughout the first trimester, and a control group. Pregnant women were followed up to record information about birth outcomes. Maternal socio-economic characteristics and main birth outcomes were evaluated. Gestational age was further analyzed using survival analysis, to determine the time distribution of delivery. RESULTS Periconceptional multi-micronutrient supplementation was associated with higher birth weight, birth length and occipitofrontal head circumference, and with lower incidence rates for stillbirth, low birth weight, and preterm birth. Moreover, periconceptional multi-micronutrient supplementation changed the time distribution of delivery, making the deliveries more clustered in the period between day 275 and day 295 of gestation. CONCLUSION Our study shows that periconceptional multi-micronutrient supplementation is beneficial for fetal development and optimizes all measured aspects of health in neonates in socioeconomically disadvantaged areas in China. The change in time distribution of deliveries caused by multi-micronutrient supplementation needs further clarification.
Pseudoelastic Behaviour of TiNi Shape Memory Alloy Subjected to Strain Variations

The pseudoelastic behaviour associated with the martensitic transformation (MT) of TiNi shape memory alloys subjected to strain variations has been investigated experimentally. The results are summarized as follows. Firstly, with respect to strain variations within the MT region: (1) The reverse transformation stress does not depend on the maximum strain. (2) The MT stress and reverse transformation stress decrease with an increase in the number of deformation cycles. (3) The rate of variation in both transformation stresses with cycling decreases with the increase in the number of cycles. Secondly, with respect to strain variations beyond the completion points of MT and reverse transformation: (1) At the start points of MT and of the reverse transformation, over shooting of both transformation stresses appears. (2) The higher the temperature and the larger the maximum strain, the larger the overshoot of both transformation stresses and the larger the decrease of the reverse transformation stress.
Spatio-Chromatic Adaptation via Higher-Order Canonical Correlation Analysis of Natural Images

Independent component and canonical correlation analysis are two general-purpose statistical methods with wide applicability. In neuroscience, independent component analysis of chromatic natural images explains the spatio-chromatic structure of primary cortical receptive fields in terms of properties of the visual environment. Canonical correlation analysis explains similarly chromatic adaptation to different illuminations. But, as we show in this paper, neither of the two methods generalizes well to explain both spatio-chromatic processing and adaptation at the same time. We propose a statistical method which combines the desirable properties of independent component and canonical correlation analysis: It finds independent components in each data set which, across the two data sets, are related to each other via linear or higher-order correlations. The new method is as widely applicable as canonical correlation analysis, and also to more than two data sets. We call it higher-order canonical correlation analysis. When applied to chromatic natural images, we found that it provides a single (unified) statistical framework which accounts for both spatio-chromatic processing and adaptation. Filters with spatio-chromatic tuning properties as in the primary visual cortex emerged and corresponding-colors psychophysics was reproduced reasonably well. We used the new method to make a theory-driven testable prediction on how the neural response to colored patterns should change when the illumination changes. We predict shifts in the responses which are comparable to the shifts reported for chromatic contrast habituation.