Miracle-dz/UniFAR-FTUs huggingface dataset:
The Seasonality and Interannual Variability of Arctic Sea Ice Reemergence

AbstractThere is a significant gap between the potential predictability of Arctic sea ice area and the current forecast skill of operational prediction systems. One route to closing this gap is improving understanding of the physical mechanisms, such as sea ice reemergence, which underlie this inherent predictability. Sea ice reemergence refers to the tendency of melt-season sea ice area anomalies to recur the following growth season and growth-season anomalies to recur the following melt season. This study builds on earlier work, providing a mode-based analysis of the seasonality and interannual variability of three distinct reemergence mechanisms. These mechanisms are studied using a common set of coupled modes of variability obtained via coupled nonlinear Laplacian spectral analysis, a data analysis technique for high-dimensional multivariate datasets. The coupled modes capture the covariability of sea ice concentration (SIC), sea surface temperature (SST), sea level pressure (SLP), and sea ice thickne.
Palagonitic Mars from rock rinds to dust; evidence from visible, near-IR, and thermal emission spectra of poorly crystalline materials

Visible and near-IR (VNIR) spectral data for Martian bright regions are characterized by a general shape consisting of a ferric absorption edge extending from about 400 to 750 nm and relatively constant reflectivity extending from about 750 nm to beyond 2000 nm . Among terrestrial geologic materials, the best spectral analogues are certain palagonic tephras from Mauna Kea Volcano (Hawaii). By definition, palagonite is a yellow or orange isotropic mineraloid formed by hydration and devitrification of basaltic glass. The ferric pigment in palagonite is nanometer-sized ferric oxide particles (np-Ox) dispersed throughout the hydrated basaltic glass matrix. The hydration state of the np-Ox particles is not known, and the best Martian spectral analogues contain allophane-like materials and not crystalline phyllosilicates. We show here that laboratory VNIR and TES spectra of palagonitic alteration rinds developed on basaltic rocks are spectral endmembers that provide a consistent explanation for both VNIR and TES data of Martian dark regions.
The Performance of Three-Sample Qualitative Immunochemical Fecal Test to Detect Colorectal Adenoma and Cancer in Gastrointestinal Outpatients: An Observational Study

Background Repeated qualitative fecal immunochemical test (qlFIT) is a clinical strategy widely used to detect lower gastrointestinal lesions, but its diagnostic power has not been assessed in opportunistic screening for colorectal neoplasia. Objective This study aimed to determine the performance of three-sample qlFIT in screening for colorectal cancer and its precursors in high-risk participants. Methods 513 gastrointestinal outpatients yielded three qlFITs before a standard colonoscopy. We evaluated the diagnostic value of one, two, and three positive qlFITs serving as the positivity threshold. The risk factors of colorectal neoplasia to yield positive qlFITs were also determined. Results 52 patients were diagnosed with colorectal cancer and 70 with advanced adenomatous polyp. For colorectal cancer, the sensitivity and specificity of one positive qlFIT were 90.4% and 53.8%, of two were 80.8% and 75.1%, and of three were 53.9% and 88.5%, respectively. For advanced adenomatous polyp, the sensitivity and specificity of one positive qlFIT were 81.4% and 54.2%, of two were 50.0% and 72.5%, and of three were 28.6% and 86.2%. Left-sided location (OR 2.50, 95%CI 1.26–4.95) and advanced histology of tumors (OR 3.08, 95%CI 1.58–6.01) were independently associated with positive qlFITs. Conclusions Three-sample qlFIT is a reasonably good method to detect colorectal neoplasia in high-risk population. Tumors in the left side or with advanced pathological features are more likely to produce positive qlFITs.
The Emergence of Social Smiling

The study addresses the emergence of the social smile in two different sociocultural contexts during the first 12 postnatal weeks. We examined different eliciting mechanisms like mutual gazing, maternal smile during mutual gazing, and reciprocal maternal and infant imitation of smiling. In co-constructivist theories of emotional development, all of them are considered social mechanisms that foster the emergence of social smile in early infancy around the 2-month shift. During the 6th postnatal week, we assumed that mutual gazing and the accompanying maternal smiles are the primary mechanisms that correspond with first infants’ social smile. From the 2-month shift onward, thus during the 8th, 10th, and 12th postnatal weeks, we assumed maternal imitation of infant smile moderates the positive relationship between infant imitation of maternal smile and the duration of infant social smile. We compared face-to-face interactions between 20 mother–child dyads from an independent sociocultural context (urban middle-class families from Münster, Germany) and 24 mother–child dyads from an interdependent sociocultural context (rural Nso families, Cameroon) when the infants were 6, 8, 10, and 12 weeks old. The first hypothesis could be corroborated for both cultural contexts, the second hypothesis only partly for the independent cultural contexts and staggered for the interdependent context. The consequences of culture-specific developmental pathways of social smile are discussed.
AMG 102, A Fully Human Anti-Hepatocyte Growth Factor/Scatter Factor Neutralizing Antibody, Enhances the Efficacy of Temozolomide or Docetaxel in U-87 MG Cells and Xenografts

Purpose: Hepatocyte growth factor (HGF/SF) and its receptor c-Met have previously been shown to be up-regulated in multiple human cancers, including glioblastoma multiforme. To better understand if AMG 102, a fully human, anti-HGF/SF–neutralizing antibody, could be incorporated into current clinical practice, AMG 102 was tested preclinically in combination with temozolomide or docetaxel to determine if enhanced efficacy was observed compared with AMG 102 alone. Experimental Design: The effects of AMG 102 were tested for antiproliferative activity in combination with temozolomide or docetaxel on U-87 MG cells in vitro and for antitumor activity in a U-87 MG xenograft model in vivo. Apoptotic activity was also measured for AMG 102 and docetaxel combined in vitro. Results: Treatment with temozolomide combined with AMG 102 resulted in increased inhibition of cell growth in vitro compared with treatment with either single agent alone. In U-87 MG xenografts in vivo, AMG 102 combined with temozolomide or docetaxel significantly increased the inhibitory effect on tumor growth when compared with treatment with either agent alone (P < 0.0001 and P < 0.015, respectively). In vitro, docetaxel alone induced both caspase-3/7 activity as well as poly(ADP)ribose polymerase and caspase-7 cleavage in U-87 MG cells; these events were enhanced when used in combination with AMG 102. Importantly, there was no evidence of interference between AMG 102 and either temozolomide or docetaxel in vitro or in vivo. Conclusion: These studies support testing of AMG 102 in combination with temozolomide or docetaxel. Such combinations may represent promising, novel clinical therapeutic strategies for cancers that are dependent on the HGF/SF/SF:c-Met pathway in the oncology setting.
Dynamical quorum-sensing and synchronization of nonlinear oscillators coupled through an external medium

Many biological and physical systems exhibit population-density dependent transitions to synchronized oscillations in a process often termed "dynamical quorum sensing". Synchronization frequently arises through chemical communication via signaling molecules distributed through an external media. We study a simple theoretical model for dynamical quorum sensing: a heterogenous population of limit-cycle oscillators diffusively coupled through a common media. We show that this model exhibits a rich phase diagram with four qualitatively distinct mechanisms fueling population-dependent transitions to global oscillations, including a new type of transition we term "dynamic death". We derive a single pair of analytic equations that allows us to calculate all phase boundaries as a function of population density and show that the model reproduces many of the qualitative features of recent experiments of BZ catalytic particles as well as synthetically engineered bacteria.
The H2O2 Stimulon in Saccharomyces cerevisiae *

The changes in gene expression underlying the yeast adaptive stress response to H2O2were analyzed by comparative two-dimensional gel electrophoresis of total cell proteins. The synthesis of at least 115 proteins is stimulated by H2O2, whereas 52 other proteins are repressed by this treatment. We have identified 71 of the stimulated and 44 of the repressed targets. The kinetics and dose-response parameters of the H2O2 genomic response were also analyzed. Identification of these proteins and their mapping into specific cellular processes give a distinct picture of the way in which yeast cells adapt to oxidative stress. As expected, H2O2-responsive targets include an important number of heat shock proteins and proteins with reactive oxygen intermediate scavenging activities. Exposure to H2O2 also results in a slowdown of protein biosynthetic processes and a stimulation of protein degradation pathways. Finally, the most remarkable result inferred from this study is the resetting of carbohydrate metabolism minutes after the exposure to H2O2. Carbohydrate fluxes are redirected to the regeneration of NADPH at the expense of glycolysis. This study represents the first genome-wide characterization of a H2O2-inducible stimulon in a eukaryote.
AN OPERATIONAL FRAMEWORK FOR INFLATION TARGETING IN EGYPT

The thesis focuses on the potential adoption of the inflation targeting (IT) regime in Egypt. Basically, it aimed at answering the following questions. (1) Should the central bank of Egypt shift to IT or continue with the current monetary policy framework, monetary aggregate targeting (MAT). (2) What the optimal policy horizon (OPH) should central bank choose to target inflation, (3) Does modelling inflation using models that allow for time-varying conditional variance, skewness and kurtosis helps in better understanding of inflation uncertainty? The main results of the thesis show that: (1) To answer the first question, the stability of velocity of money in circulation and money multiplier has been analysed using variance ratio tests and found unstable. Therefore, we could conclude that the current MAT framework cannot achieve its ultimate goal of price stability and it is believed that shifting to IT framework is highly recommended. (2) Concerning the OPH, the results show that the OPH is largely dependent on the nature of the shock and on a central bank’s preferences over goals. Thus, for different kinds of the shocks, even if they are generally classified of the same type, the concern of the central bank about other policy objectives affects the policy horizon. With respect to shock persistence, the results demonstrate that the horizon increases with the persistence of the shock as persistent shock distributed over many period in comparison with transitory and less persistent shocks. (3) To answer the third question, the methodology proposed by Leon, Rubio, and Serna (2005) for modelling nonconstant conditional second, third and fourth moments is applied. The results indicate that models with nonconstant second, third and fourth moments are superior to models with time invariant volatility, skewness and kurtosis.
The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma

Deregulation of mTOR and IGF pathways is frequent in hepatocellular carcinoma (HCC), thus mTOR and IGF1R represent suitable therapeutic targets in HCC. The aim of this study was to evaluate the effects of mTOR inhibitors (mTORi) and OSI-906, blocker of IGF1R/IR, on HCC cell proliferation, viability, migration and invasion, and alpha-fetoprotein (α-FP) secretion. In HepG2 and HuH-7 we evaluated, the expression of mTOR and IGF pathway components; the effects of Sirolimus, Everolimus, Temsirolimus and OSI-906 on cell proliferation; the effects of Sirolimus, OSI-906, and their combination, on cell secretion, proliferation, viability, cell cycle, apoptosis, invasion and migration. Moreover, intracellular mechanisms underlying these cell functions were evaluated in both cell lines. Our results show that HepG2 and HuH-7 present with the same mRNA expression profile with high levels of IGF2. OSI-906 inhibited cell proliferation at high concentration, while mTORi suppressed cell proliferation in a dose-time dependent manner in both cell lines. The co-treatment showed an additive inhibitory effect on cell proliferation and viability. This effect was not related to induction of apoptosis, but to G0/G1 phase block. Moreover, the co-treatment prevented the Sirolimus-induced AKT activation as escape mechanism. Both agents demonstrated to be differently effective in inhibiting α-FP secretion. Sirolimus, OSI-906, and their combination, blocked cell migration and invasion in HuH-7. These findings indicate that, co-targeting of IGF1R/IR and mTOR pathways could be a novel therapeutic approach in the management of HCC, in order to maximize antitumoral effect and to prevent the early development of resistance mechanisms.
Food-Bridging: A New Network Construction to Unveil the Principles of Cooking

In this manuscript we propose, analyse, and discuss a possible new principle behind traditional cuisine: the Food-bridging hypothesis and its comparison with the food-pairing hypothesis using the same dataset and graphical models employed in the food-pairing study by Ahn et al. [Scientific Reports,1:196,2011]. The Food-bridging hypothesis assumes that if two ingredients do not share a strong molecular or empirical affinity, they may become affine through a chain of pairwise affinities. That is, in a graphical model as employed by Ahn et al., a chain represents a path that joints the two ingredients, the shortest path represents the strongest pairwise chain of affinities between the two ingredients. Food-pairing and Food-bridging are different hypotheses that may describe possible mechanisms behind the recipes of traditional cuisines. Food-pairing intensifies flavour by mixing ingredients in a recipe with similar chemical compounds, and food-bridging smoothes contrast between ingredients. Both food-pairing and food-bridging are observed in traditional cuisines, as shown in this work. We observed four classes of cuisines according to food-pairing and food-bridging: (1) East Asian cuisines, at one extreme, tend to avoid food-pairing as well as food-bridging; and (4) Latin American cuisines, at the other extreme, follow both principles. For the two middle classes: (2) Southeastern Asian cuisines, avoid food-pairing and follow food-bridging; and (3) Western cuisines, follow food-pairing and avoid food-bridging.
Conversion to pine: Changes in timing and magnitude of high and low flows

Abstract Understanding watershed responses to extreme events is important for assessing potential impacts of floods, droughts, episodic pollution, and other external driving variables on watershed resources. In this study, we combine trend and frequency analyses with paired watershed techniques to evaluate the long-term high- and low-flow data from Coweeta Hydrologic Laboratory in North Carolina, USA in an attempt to quantify and interpret responses to extreme flow events in managed and unmanaged watersheds. Two experimental watersheds were converted from mixed deciduous forest cover to pine (Pinus strobus L.) in 1957 and 1956, respectively and two others were kept untreated to serve as control watersheds. Seventy years of annual streamflow (instantaneous maximum, minimum, and mean) time series data from watersheds 1, 2, 17, and 18 were analyzed with a Mann–Whitney–Pettitt test to identify and compare change points. Mean annual streamflow increased in both watersheds for 10–12 years after harvests, but the more effective factor on the flow series was the growth of pine plantations. Maximum flows of 2-, 5-, and 10-year return periods decreased after planting pine, but there was no difference for larger flow events compared to deciduous forest. For minimum flows, pine stands were more effective compared to maximum flows as minimum flows decreased for all return periods.
A Bayesian approach to tracking multiple targets using sensor arrays and particle filters

We present a Bayesian approach to tracking the direction-of-arrival (DOA) of multiple moving targets using a passive sensor array. The prior is a description of the dynamic behavior we expect for the targets which is modeled as constant velocity motion with a Gaussian disturbance acting on the target's heading direction. The likelihood function is arrived at by defining an uninformative prior for both the signals and noise variance and removing these parameters from the problem by marginalization. Advances in sequential Monte Carlo (SMC) techniques, specifically the particle filter algorithm, allow us to model and track the posterior distribution defined by the Bayesian model using a collection of target states that can be viewed as samples from the posterior of interest. We describe two versions of this algorithm and finally present results obtained using synthetic data.
Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection

Sepsis, the systemic inflammatory response to microbial infection, induces changes in both innate and adaptive immunity that presumably lead to increased susceptibility to secondary infections, multiorgan failure, and death. Using a model of murine polymicrobial sepsis whose severity approximates human sepsis, we examined outcomes and defined requirements for survival after secondary Pseudomonas aeruginosa pneumonia or disseminated Listeria monocytogenes infection. We demonstrate that early after sepsis neutrophil numbers and function are decreased, whereas monocyte recruitment through the CCR2/MCP-1 pathway and function are enhanced. Consequently, lethality to Pseudomonas pneumonia is increased early but not late after induction of sepsis. In contrast, lethality to listeriosis, whose eradication is dependent upon monocyte/macrophage phagocytosis, is actually decreased both early and late after sepsis. Adaptive immunity plays little role in these secondary infectious responses. This study demonstrates that sepsis promotes selective early, impaired innate immune responses, primarily in neutrophils, that lead to a pathogen-specific, increased susceptibility to secondary infections.
The Housing Wealth of the Aged

This paper examines the degree to which the elderly reduce homeownership as they age, and the factors which influence this process. We find that average levels of homeownership decline significantly with age, even when cohort effects are taken into consideration, and that the amount of housing held by people near death is quite low compared to what is seen in cross sections. We estimate that 42% of households will leave behind a house when the last member dies. We also find that the degree to which households reduce homeownership between age 65 and death does not differ greatly between the upper and lower income halves of our sample; that people who do not have children reduce their homeownership more slowly than those who do; that increases in house prices in a state make it more likely that the elderly in that state reduce their home equity; and that the value of houses sold by elderly people tends not remain in their portfolios after the house is sold.
Obsessive-Compulsive Spectrum Disorders: A Review of the Evidence-Based Treatments

Objective: To provide a review of the evidence-based treatments for Obsessive-Compulsive spectrum disorders (OCSD), a group of conditions related to Obsessive-Compulsive disorder (OCD) by phenomenological and etiological similarities, the morbidity of which is increasingly recognized. Method: Literature relating to the following disorders: body dysmorphic disorder, hypochondriasis, trichotillomania, onychophagia, psychogenic excoriation, compulsive buying, kleptomania, and pathological gambling, and published between January 1965 and October 2007, was found using PubMed. Included in this review were 107 treatment reports. Results: Serotonin reuptake inhibitors (SRIs) have shown benefits as first-line, short-term treatments for body dysmorphic disorder, hypochondriasis, onychophagia, and psychogenic excoriation, with some benefits in trichotillomania, pathological gambling, and compulsive buying. There are also suggested benefits for several atypical antipsychotics in disorders with a high degree of impulsivity, including trichotillomania and pathological gambling, and to a lesser extent, kleptomania and psychogenic excoriation. Cognitive-behavioural interventions have generally shown evidence for use as first-line treatment across the spectrum, with some variability in degree of benefit. Conclusions: As in OCD, several conditions in the proposed OCSD benefit from SRIs and (or) cognitive-behavioural interventions. However, the treatment literature is generally limited, and more randomized controlled trials (RCTs) are needed to evaluate individual and combination treatments, for short-term use and as maintenance.
Acoustic communication in the Palaearctic red cicada, Tibicina haematodes: chorus organisation, calling-song structure, and signal recognition

Males of the Palaearctic red cicada, Tibicina haematodes, produce calling songs that are attractive to both sexes. For the first time we (i) describe the organisation of the chorus formed by aggregating males, (ii) analysed the physical characteristics of the calling song, and ( iii) used playback experiments of natural, modified, and allospecific signals to investigate the signal-recognition process. Males overlap each other's calling song and try to call first and last during a chorus, leading to what we term domino and last-word effects, respectively. The calling song consists of a two-part sequence made up of a succession of pulses. It is characterized by slow and fast amplitude modulations and three frequency bands. The structure of the signal varied among individuals in both temporal and frequency parameters. Our playback experiments showed that males make a rough analysis of frequency and duration features of the signal. They pay no attention to amplitude modulations. Because males are not capable of precise analysis, they reply to vari- ous allospecific calling songs. Females' analysis of the calling song being difficult to test, the role of this signal in sex - ual selection still needs to be documented.
The Impacts of ICTs on Banks A Case study of the Nigerian Banking Industry

ICT has taken the center stage in almost every aspect of human endeavor. ICT help banks improve the efficiency and effectiveness of services offered to customers, and enhances business processes, managerial decision making, and workgroup collaborations, which strengthens their competitive positions in rapidly changing and emerging economies. This paper considers the impacts and trends of ICTs on the banking industry of the 21 century. Four (4) parameters, namely: productivity, market structure, Innovation and value chain were used for benchmarking. Case studies of the IT platform employed by two Nigerian banks were included to for a more informed inference. KeywordsBanking industry; CBN; Customers; Economic growth;
An Unfolding Tragedy of Chagas Disease in North America

In North America, Chagas disease (American trypanosomiasis caused by Trypanosoma cruzi) was first reported in Mexico in 1940 [1] and in the United States in Texas in 1955 [2]. However, based on ancient mummified remains discovered in the Rio Grande Valley, human T. cruzi infection has been present in North America since prehistoric times [3].