Miracle-dz/UniFAR-FTUs huggingface dataset:
A risk stratification model for antihypertensive medication non-adherence among Chinese immigrants

The purpose of this study was to establish a risk stratification model for identifying Chinese immigrants at risk for non-adherence to antihypertensive medications. Questionnaires were self-administered to 200 Chinese immigrants in San Francisco, USA. Questionnaires included demographics, culture factors (e.g., Perceived Susceptibility in General, Perceived Benefits of Western Medication, Perceived Benefits of Chinese Herbs, and HealthRelated Social Support), and medications adherence. Participants' mean age was 70.6 (±10.3) years. Three stratification factors were identified for non-adherence: Lower Perceived Susceptibility in General, lower Perceived Benefit of Western Medications, and longer Length of Stay in the United States. The probability of non-adherence was 77%, 62%, and 57% for lower perceived susceptibility, longer stay in the United States, and lower perceived benefits of Western medications, respectively. A combination of lower perceived susceptibility and lower perceived benefits of medication predicted 81% non-adherence and lower perceived susceptibility with longer stay in the United States predicted at 84%. All three factors combined predicted nearly 90%. Patients with all three factors had the highest risk for non-adherence. The second priority groups are patients with lower perceived susceptibility and those with lower perceived susceptibility combined with any of the other two factors. In the clinical setting, these three groups are a high priority for education on the importance of medication adherence.
Pedestrian tracking using inertial sensors

A personal navigation system is proposed in the present paper. This system is based on the use of inertial sensors and will be a complement for the Global Positioning System in places where GPS signals are not available. Such places are indoors and outdoors without a clear visibility of the sky (urban canyons, places under dense foliage.). A known initial position is required for this method for it to be able to estimate the trajectory of the pedestrian using inertial sensors attached to the foot. The developed method and the approximations taken into account are explained. Finally, the results of several tests carried out are shown.
Assessing Risk of Unintended Antigen Occurrence in Food: A Case Instance for Maize-Expressed LT-B

ABSTRACT Plant-based antigen production represents an innovative strategy for low cost vaccine production and delivery. Successfully advancing plant-made antigen production in open field systems requires understanding of confinement integrity and consequences of inadvertent occurrence in the food supply. The food safety implications of confinement loss and inadvertent antigen occurrence in the food supply can be effectively addressed using quantitative exposure assessment along with knowledge of properties of specific antigens. We report here a food safety risk assessment for the maize-expressed heat-labile enterotoxin subunit B of Escherichia coli (LT-B). In addition to dietary exposure assessment, food safety considerations for maize-expressed LT-B included assessment of allergenic potential, levels and sites of transgenic protein expression, history of use, post-translational glycosylation, protein processing and digestive stability, mammalian functionality and toxicity, and compositional characteristics of the transformed plant. As shown for LT-B, inadvertent occurrence in the food supply of a plant-produced antigen constitutes a minimal human health concern principally because of limited exposure potential.
Positive Interaction of Social Comparison and Personal Responsibility for Outcomes

We formulate and test a model that allows sharp separation between two different ways in which environment affects evaluation of outcomes, by comparing social vs. private and personal responsibility vs. chance. In the experiment, subjects chose between two lotteries, one low-risk and one high-risk. They could then observe the outcomes. By varying the environment between private (they could observe the outcome of the chosen lottery and the outcome of the lottery they had not chosen) and social (they could observe the outcome of the lottery chosen by another subject) we can differentiate the response and brain activity following the feedback in social and private settings. The evidence suggests that envy and pride are significant motives driving decisions and outcomes evaluation, stronger than private emotions like regret and rejoice, with ventral striatum playing a key role. When we focus on the outcome evaluation stage we demonstrate that BOLD signal in ventral striatum is increasing in the difference between obtained and counterfactual payoffs. For a given difference in payoffs, striatal responses are more pronounced in social than in private environment. Moreover, a positive interaction (complementarity) between social comparison and personal responsibility is reflected in the pattern of activity in the ventral striatum. At decision stage we observe getting ahead of the Joneses effect in ventral striatum with subjective value of risk larger in social than in private environment.
OSCILLATORY BEHAVIOR OF THE SQUID AXON MEMBRANE POTENTIAL

Squid axons impaled with a microelectrode have been treated with concentrations of xylene and benzene such that there is no change in threshold or resting potential at 20°C. , while the spike height declines about 10 mv. A decrease in ambient temperature results in large, reversible, increases in threshold. While neither low temperature nor the added blocking agent induces repetitive firing from a single stimulus, the two treatments when combined do yield repetitive responses which commence at a sharply defined temperature. The alteration in the membrane responsible for the effects observed can be described by saying that there has been a large increase in the inductance of the equivalent electric circuit, and the temperature coefficient of the apparent membrane inductance has a Q 10 = 5.
Activation of different vestibular subnuclei evokes differential respiratory and pressor responses in the rat

Activation of the vestibular system can either increase or decrease ventilation. The objectives of the present study were to clarify whether these different responses are the result of activating different vestibular subnuclei, by addressing three questions. Do neurones within the medial, lateral and spinal vestibular nuclei (VNM, VNL and VNS, respectively) function differently in respiratory modulation? Is the ventral medullary nucleus gigantocellularis (NGC) required to fully express the VN‐mediated respiratory responses? Is glutamate, by acting on N‐methyl‐d‐aspartic acid (NMDA) receptors in the vestibular subnuclei, capable of modulating respiration? In anaesthetized, tracheotomized and spontaneously breathing rats, electrical stimuli (< 10 s) applied in the VNL and VNS significantly elevated ventilation by 35 % and 30 % (P < 0.05), respectively. However, VNM stimulation produced statistically significant (P < 0.05) changes that differed depending upon the stimulation site: either ventilatory inhibition (by 40 % in 57 % of the trials) or excitation (by 55 % in 43 % of trials), and which were often accompanied by a pressor response. These electrical‐stimulation‐evoked cardiorespiratory responses were almost eliminated following microinjection of ibotenic acid into the stimulation sites (P < 0.05) or bilaterally into the NGC (P < 0.05). As compared to vehicle, microinjection of NMDA into the unilateral VNM, VNL and VNS significantly increased ventilation to 74 %, 58 % and 60 % (P < 0.05), respectively, with no effect on arterial blood pressure. These data suggest that neurones within the vestibular subnuclei play different roles in cardiorespiratory modulation, and that the integrity of the NGC is essential for the full expression of these VN‐mediated responses. The evoked respiratory excitatory responses are probably mediated by glutamate acting on NMDA receptors, whereas the neurotransmitters involved in VNM‐mediated respiratory inhibition and hypertension remain unknown.
Requirement of polysialic acid for the migration of the O-2A glial progenitor cell from neurohypophyseal explants

While the capacity of O-2A oligodendrocyte progenitors to migrate in cell culture and during in vivo myelin formation is well documented, little is known about factors that regulate the motility of these cells. Here, we report on an in vitro model that allowed us to evaluate the contribution of alpha 2–8 linked polysialic acid (PSA) to O-2A cell motility. Using explant cultures of newborn rat neurohypophysis, we observed that individual glial fibrillary acidic protein (GFAP)- positive cells rapidly disperse from the explants, and that cells of the O-2A lineage predominate in the migratory cell pool. Presumed O-2A progenitor cells had a round or bipolar morphology and presented both A2B5 and GFAP immunoreactivity. When cultured in medium containing 10% fetal calf serum, these cells differentiated into stellate-shaped, A2B5/GFAP-positive type 2 astrocytes. In serum-free medium most of them developed into O4/galactocerebroside-positive oligodendrocytes. O-2A lineage cells were found only in a specific developmental period extending from embryonic day 21 to postnatal day 3. A monoclonal antibody, which recognizes the alpha 2–8 linked PSA, characteristic of the embryonic form of NCAM, revealed immunoreactivity on the surface of O-2A progenitor cells, whereas mature oligodendrocytes, type 2, type 1 astrocytes as well as flat GFAP-negative cells were negative. Treatment of the explants with endoneuraminidase purified from phage K1, which specifically removes PSA from the surface of the cell, resulted in a complete blockade of the dispersion of O-2A lineage population from the explant. The effects of the enzymatic treatment were both selective and reversible: migration of GFAP-negative fibroblast-like cells that are normally PSA negative was not influenced, and upon removal of the enzyme, cells of the O-2A lineage were readily detectable in the migrating population. These results provide direct evidence that alpha 2–8 linked PSA contribute to the motility of O-2A, glial progenitor cells.
Possible contribution of apoptosis‐inducing factor (AIF) and reactive oxygen species (ROS) to UVB‐induced caspase‐independent cell death in the T cell line Jurkat

We analyzed the mechanism of UVB‐induced cell death using the Jurkat T cell line. Apoptosis was assessed by measuring phosphatidylserine (PS) externalization, caspase activity, the decrease in mitochondrial membrane potential (ΔΨm), nucleosomal DNA fragmentation, and morphological changes such as chromatin condensation. The mitochondrio‐nuclear translocation of apoptosis‐inducing factor (AIF) was evaluated by confocal laser microscopy. The cell death pattern of UVB‐irradiated cells was similar to the Fas‐induced cell death pattern. However, zVAD‐fmk inhibited the nucleosomal fragmentation of DNA but not the externalization of PS, decrease in ΔΨm, or mitochondrio‐nuclear translocation of AIF. N‐acetyl L‐cysteine significantly inhibited the translocation of AIF induced by UVB. These results suggested that caspase‐dependent and ‐independent pathways were involved in UVB‐induced cell death in Jurkat cells, and the mitochondrio‐nuclear translocation of AIF was associated with the latter pathway. In addition, reactive oxygen species generated by UVB might be involved in inducing the mitochondrio‐nuclear translocation of AIF.
Effect of Basalt Fiber on the Asphalt Binder and Mastic at Low Temperature

The effect of basalt fiber on asphalt binder and mastic at low temperatures is investigated in this study. Basalt fibers are dispersed into the asphalt binder and mastic specimens to prepare the fiber-reinforced binding materials. The fiber-reinforced specimens are tested using the direct tension test and a newly developed fatigue test procedure, which is able to directly apply cyclic tensile loading to the asphalt binder and mastic specimens. The reinforcement effects of basalt fiber to the fatigue resistance of asphalt binding materials are evaluated. The direct tension test results show that with an appropriate content, the tensile strength of the asphalt binder is improved with the use of basalt fiber. The basalt fiber also restrains the axial strain and increases the stiffness of both the asphalt binder and mastic specimens. The fatigue test results indicate that the fatigue life of both asphalt binder and mastic specimens is significantly improved by the basalt fibers. The effect of basalt fibers is also analyzed using numerical simulations of direct tension and fatigue tests based on the finite-element method. The internal structure of the fiber-reinforced mastic is considered with the assistance of X-ray tomography technology. The fiber-reinforced mastic model is a heterogeneous composite in which the asphalt binder, fillers, and basalt fibers are treated as different materials. The axial stress and strain of the model are analyzed under unidirectional tensile loading and cyclic tensile loading. The results show that the fiber added between fillers releases the stress concentration of the critical area and diminishes the fatigue damage caused by cyclic loading.
En‐Bloc Kidney Transplantation in the United States: An Analysis of United Network of Organ Sharing (UNOS) Data from 1987 to 2003

With increasing donor organ shortages, en‐bloc kidney (EBK) transplantation is an alternative to utilize very young or very old donor age cadaver kidneys for transplantation. Several single‐center series have reported excellent graft survival (GS). We sought to determine national level registry‐based patterns for GS and determine adjusted hazard ratios (AHR) for graft loss after EBK versus single kidney (SK) cadaver transplants.
Nasal obstruction: comparison of radiofrequency with lateral displacement of the inferior turbinate and radiofrequency alone.

OBJECTIVE To compare the outcomes of the nasal obstruction, the main symptom of the patients who underwent radiofrequency and lateral displacement of the inferior turbinate and patients who were treated with radiofrequency alone. METHODS The prospective randomised study was conducted at the Department of Otorhinolaryngology and Head-Neck Surgery, Balikesir University Medical School, Balikesir, Turkey, between July and December 2012. It included 60 patients, diagnosed with allergic or non-allergic chronic rhinitis with inferior turbinate hypertrophy which was refractory to medical therapy. Half of the patients were treated with radiofrequency, and the rest with radiofrequency and lateral displacement. The main symptom of the patients was nasal obstruction. The frequency and degree of nasal obstruction were evaluated by patients' self-assessments using the standard 10-cm visual analogue scale. The evaluations were performed first pre-operatively and on the 1st, 3rd, 5th and 7th days postoperatively as well as at the end of the 4th week. SPSS 18 was used for statistical analysis. RESULTS Nasal obstruction frequency and severity scores in patients treated with both radiofrequency and lateral displacement on post-operative days 3, 5 and 7 were found to be significantly lower (p<0.001) compared to the patients treated with only radiofrequency. CONCLUSIONS The study demonstrated that radiofrequency and lateral displacement together is an effective method to prevent inferior turbinate oedema in the early post-operative period.
Situational and Dispositional Influences on Nurses' Workplace Well-being: The Role of Empowering Unit Leadership

Background:Unit-level leadership and structural empowerment play key roles in creating healthy work environments, yet few researchers have examined these contextual effects on nurses' well-being. Objectives:The aim of this study was to test a multilevel model of structural empowerment examining the effect of nursing unit leadership quality and structural empowerment on nurses' experiences of burnout and job satisfaction and to examine the effect of a personal dispositional variable, core self-evaluation, on these nurse experiences. Methods:Nurses (n = 3,156) from 217 hospital units returned surveys that included measures of leader-member exchange, structural empowerment, burnout, core self-evaluation, and job satisfaction. Multilevel structural equation modeling was used to test the model. Results:Nurses' shared perceptions of leader-member exchange quality on their units positively influenced their shared perceptions of unit structural empowerment (Level 2), which resulted in significantly higher levels of individual nurse job satisfaction (Level 1). Unit-level leader-member exchange quality also directly influenced individual nurse job satisfaction. Unit leader-member exchange quality and structural empowerment influenced emotional exhaustion and cynicism differentially. Higher unit-level leader-member exchange quality was associated with lower cynicism; higher unit-level structural empowerment was associated with lower emotional exhaustion. At Level 1, higher core self-evaluation was associated with lower levels of both emotional exhaustion and cynicism, both of which were associated with lower job satisfaction. Discussion:This study provides a theoretical understanding of how unit leadership affects both unit- and individual-level outcomes.
Risperidone in combination with mood stabilizers for acute mania: a multicentre, open study

The primary aims of this study were (i) a replication of the effectiveness and tolerability of risperidone in the treatment of patients with acute mania in a very large cohort in a naturalistic treatment setting and (ii) to extend the data on the effect and tolerability of risperidone in the treatment of patients with acute mania to an Asian population. A total of 909 patients fulfilling DSM-IV criteria of bipolar disorder (current manic and hypomanic episode) entered this large, open, multicentre study. The Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI) and Simpson–Angus Rating Scale (SARS) were measured at baseline and weeks 1, 3 and 6, for the assessment of effectiveness and extrapyramidal symptoms. This study showed a statistically significant reduction of scores on the YMRS and CGI-severity (mean change=−23.5±11.8, P<0.0001; mean change=−2.7±1.5, P<0.0001, respectively) from baseline to endpoint (week 6). The number of patients with a 50% reduction or more in the YMRS and CGI-severity scores was 693 (77.8%) and 630 (70.7%) at endpoint, respectively. There were no statistically significant increments of scores on SARS. Risperidone was generally well tolerated. The present larger open study indicates that risperidone add-on therapy is effective and tolerable in treatment of bipolar disorder, replicating results in various controlled and uncontrolled studies from Western countries.
Average midrange ultraviolet radiation flux and time outdoors predict melanoma risk.

Sunlight is the major environmental risk factor for melanoma. Descriptive studies have shown latitudinal variation in population incidence and mortality rates [D. C. Whiteman and A. C. Green, Int. J. Dermatol. , 38: 481-489, 1999, and B. K. Armstrong, Australian J. Dermatol. , 38 (Suppl. 1): 51-56, 1997]. In analytic studies, individual exposure has been particularly difficult to quantify. Lifetime residential history was coupled with levels of midrange UV radiation (UVB flux) to provide a measure of individual exposure to sunlight thought to be less subject to misclassification and recall bias. Data were analyzed from 718 non-Hispanic white patients with invasive cutaneous melanoma from melanoma clinics in Philadelphia and San Francisco. Matched controls were 945 patients from outpatient clinics with similar catchment areas. The association of melanoma risk and history of UVB flux along with the usual outdoor exposure risk factors were studied. A 10% increase in the average annual UVB flux was associated with a 19% [95% confidence interval (CI), 5-35%] increase in individual odds for melanoma for men and 16% (95% CI, 2-32%) for women. In men, a 10% increase in hours outdoors was associated with a 2.8% (95% CI, 1.2-4.5%) increase in odds. Even in women who could develop a deep tan, a 10% increase in hours outdoors was associated with a 5.8% increase in odds (95% CI, 1.4-10.4%). The association between melanoma risk and average annual UVB flux was strong and consistent for men and for women. The association with total adult hours outdoors was notable for men of all skin types and women who develop a suntan.
Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

Objective Patients with IBD display substantial heterogeneity in clinical characteristics. We hypothesise that individual differences in the complex interaction of the host genome and the gut microbiota can explain the onset and the heterogeneous presentation of IBD. Therefore, we performed a case–control analysis of the gut microbiota, the host genome and the clinical phenotypes of IBD. Design Stool samples, peripheral blood and extensive phenotype data were collected from 313 patients with IBD and 582 truly healthy controls, selected from a population cohort. The gut microbiota composition was assessed by tag-sequencing the 16S rRNA gene. All participants were genotyped. We composed genetic risk scores from 11 functional genetic variants proven to be associated with IBD in genes that are directly involved in the bacterial handling in the gut: NOD2, CARD9, ATG16L1, IRGM and FUT2. Results Strikingly, we observed significant alterations of the gut microbiota of healthy individuals with a high genetic risk for IBD: the IBD genetic risk score was significantly associated with a decrease in the genus Roseburia in healthy controls (false discovery rate 0.017). Moreover, disease location was a major determinant of the gut microbiota: the gut microbiota of patients with colonic Crohn's disease (CD) is different from that of patients with ileal CD, with a decrease in alpha diversity associated to ileal disease (p=3.28×10−13). Conclusions We show for the first time that genetic risk variants associated with IBD influence the gut microbiota in healthy individuals. Roseburia spp are acetate-to-butyrate converters, and a decrease has already been observed in patients with IBD.
De novo autoimmune hepatitis following living‐donor liver transplantation for primary biliary cirrhosis

Abstract: Since first being described in 1998, de novo autoimmune hepatitis (AIH) after liver transplantation has been reported in several cases suffering from non‐autoimmune liver diseases and primary biliary cirrhosis (PBC). Glutathione S‐transferase (GST) T1 genotype mismatches between donor and recipient have also been suggested to constitute a risk factor for de novo AIH. Here, we report a 33‐yr‐old woman who presented complaining of marked fatigue and jaundice four yr after living‐donor liver transplantation for PBC. On examination, transaminase levels were highly elevated and ANA and antimitochondrial antibody M2 were positive. Histological findings showed zonal necrosis with lymphoplasmacytic infiltration closely resembling AIH. She had pretreatment AIH score of 16 and 19 points after relapse of de novo AIH. Two color fluorescence in situ hybridization with X and Y chromosome‐specific probes clearly revealed that the hepatocytes were of donor origin and lymphocytes were of patient origin. The GSTT1 genotype of the patient and the donor were the same null type, suggesting that mechanisms other than GSTT1 mismatches may exist in de novo AIH development. In conclusion, recipient immune cells attacked the allogeneic transplanted liver of the patient via de novo AIH, although the exact participation of autoimmune mechanisms is unclear.