Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of atorvastatin and atorvastatin withdrawal on soluble CD40L and adipocytokines in patients with hypercholesterolaemia

Objective — Beyond lipid lowering, statins have pleiotropic effects with favourable benefits against atherogenesis.Withdrawal of statin therapy has been demonstrated to abrogate vascular protective activity and even increase the incidence of thrombotic vascular events.The purpose of this study is to investigate the serial changes of soluble CD40 ligand (sCD40L) and two adipocytokines, adiponectin and resistin, after short-term atorvastatin therapy and withdrawal in patients with hypercholesterolaemia. Methods and results — Thirty-two patients with hypercholesterolaemia received atorvastatin 10 mg/day for 3 months. Serum lipid profiles, and levels of sCD40L, adiponectin and resistin, were assessed before and immediately after 3 months’ statin therapy. Serum levels of sCD40L and adiponectin were also measured on the 3 consecutive days after statin withdrawal. After 3 months’ statin therapy, levels of sCD40L (1.93 ± 1.13 vs. 1.30 ± 0.97 ng/mL), total cholesterol and low-density lipoprotein cholesterol (LDL-C) were all reduced significantly (p < 0.05). However, sCD40L level tended to increase towards baseline on the first and second days after statin withdrawal, but was not significantly elevated until the third day after withdrawal (1.89 ± 1.28 vs. 1.30 ± 0.97 ng/mL, p < 0.05). Total cholesterol and LDL-C levels did not increase during the 3 days of statin withdrawal. No significant changes of adiponectin and resistin levels were shown after statin therapy. Conclusions — These results indicate that the effect of statin on sCD40L level was abrogated after therapy withdrawal, and was independent of serum cholesterol level. Statin therapy did not significantly alter levels of adiponectin and resistin.
Respiratory syncytial virus infection in children hospitalized for wheezing: Virus‐specific studies from infancy to preschool years

Aim: To evaluate whether the presence of immunoglobulin G (IgG) antibodies against respiratory syncytial virus (RSV) in early childhood is associated with later asthma, and to evaluate a new diagnostic test for RSV, reverse‐transcription polymerase chain reaction (RT‐PCR), comparing it to the antigen and antibody assays initially used in RSV diagnostics in the present cohort. Methods: At the start of the study in 1992–1993, RSV was studied by antigen detection (using time‐resolved fluoroimmunoassay) and complement‐fixing antibody assay. Advances in methodology allowed us to supplement RSV studies by RT‐PCR in frozen nasopharyngeal aspirates obtained on admission, and by specific IgG antibodies (using enzyme immunoassay) in frozen serum samples obtained during the follow‐up. Results: On admission, 29 of the 100 children hospitalized for wheezing at <2 y of age were RSV positive. When compared with conventional methods, the sensitivity of RT‐PCR was 83% (100% w.r.t. antigen detection) and its specificity was 92% in diagnosing RSV infection. RSV‐specific IgG antibody concentrations rose with age, but were not predictive of asthma at any age. In the present cohort, wheezing without RSV was particularly associated with increased risk for later childhood asthma.
The effectiveness of Otto’s World of Sound computer-based auditory training for improving auditory discrimination and auditory attention skills in children who have a hearing impairment

This study investigated the effects of computer-based auditory training software (Otto’s World of Sound) on auditory discrimination, speech perception and auditory attention skills in New Zealand children who have a hearing impairment. Four school-age participants with moderate to profound hearing loss participated in the study. A pre versus post test case study series design was employed to obtain pilot information on effectiveness of the intervention. The results for speech perception and auditory attention skills were promising. Hence further research is warranted using Otto’s World of Sound computer-based auditory training to demonstrate efficacy of the training, using a larger group of participants in a randomised controlled trial.
Artificial Consciousness: Utopia or Real Possibility?

Since the beginnings of computer technology, researchers have speculated about the possibility of building smart machines that could compete with human intelligence. Given the current pace of advances in artificial intelligence and neural computing, such an evolution seems to be a more concrete possibility. Many people now believe that artificial consciousness is possible and that, in the future, it will emerge in complex computing machines. However, a discussion of artificial consciousness gives rise to several philosophical issues: can computers think or do they just calculate? Is consciousness a human prerogative? Does consciousness depend on the material that comprises the human brain, or can computer hardware replicate consciousness? Answering these questions is difficult because it requires combining information from many disciplines including computer science, neurophysiology, philosophy, and religion. Further, we must consider the influence of science fiction, especially science fiction films, when addressing artificial consciousness. As a product of the human imagination, such works express human desires and fears about future technologies and may influence the course of progress. At a societal level, science fiction simulates future scenarios that can help prepare us for crucial transitions by predicting the consequences of significant technological advances. The paper considers robots in science fiction, the Turing test, computer chess and artificial consciousness.
Lymphomatoid Granulomatosis—A Single Institute Experience: Pathologic Findings and Clinical Correlations

Lymphomatoid granulomatosis (LYG) is a rare angiocentric and angiodestructive Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorder. It is hypothesized that these patients have dysregulated immune surveillance of EBV. We reviewed the biopsies of 55 patients with LYG who were referred for a prospective trial at the National Cancer Institute (1995 to 2010) and evaluated the histologic, immunohistochemical, in situ hybridization, and molecular findings of these biopsies in conjunction with clinical information. Grading of the lesions was based on morphologic features and the number of EBV-positive B cells. The median age was 46 years (M:F 2.2:1). Clinically, all patients had lung involvement (100%), with the next most common site being the central nervous system (38%). No patient had nodal or bone marrow disease. All patients had past EBV exposure by serology but with a low median EBV viral load. We reviewed 122 biopsies; the most common site was lung (73%), followed by skin/subcutaneous tissue (17%); other sites included kidney, nasal cavity, gastrointestinal tract, conjunctiva, liver, and adrenal gland. Histologically, the lesions showed angiocentricity, were rich in T cells, had large atypical B cells, and were positive for EBV. Grading was performed predominantly on the lung biopsy at diagnosis; they were distributed as follows: LYG grade 1 (30%), grade 2 (22%), and grade 3 (48%). Necrosis was seen in all grades, with a greater degree in high-grade lesions. Immunoglobulin gene rearrangement studies were performed, and a higher percentage of clonal rearrangements were seen in LYG grade 2 (50%) and grade 3 (69%) as compared with grade 1 (8%). LYG is a distinct entity that can usually be differentiated from other EBV-associated B-cell lymphoproliferative disorders on the basis of the combination of clinical presentation, histology, and EBV studies. Grading of these lesions is important because it dictates the treatment choice.
Chymosin and other milk coagulants: sources and biotechnological interventions

Calf rennet, which consists of over 90% chymosin, is commonly used in cheese industries for the curdling of milk. Various animal, plant and microbial sources have been exploited as possible alternatives to calf rennet. The coagulating properties of the enzymatic preparations (coagulants) from these sources differ in terms of their physicochemical factors. The cheese industry has always sought out novel and stable enzyme sources, and recombinant chymosin has been found to be an effective alternative since it possesses several advantages over plant and microbial milk-clotting enzymes. This paper reviews the use of various milk coagulants, especially animal coagulants, for cheese making. Advancements in genetic and protein engineering to produce recombinant chymosin are discussed in addition to evaluating its identity to the rennet available from natural sources.
Environmentally Concerned Logistics Operations in Fuzzy Environment: A Literature Survey

Growing environmental awareness coupled with stricter governmental regulations has fueled the need for integrating sustainability into supply chain and logistics activities. Accordingly, recent studies in the literature have emphasized the significance of environmentally concerned logistics operations (ECLO). Research in the broad area of ECLO encompasses a wide range of topics including sustainable supply chain, green supply chain, closed-loop supply chain, low-carbon logistics, and waste management. In this paper, a comprehensive content analysis and area review is presented. Over 800 papers published between 1994 and 2017 in peer-reviewed journals, proceedings, and book chapters are utilized. These papers are analyzed in consecutive stages after being reviewed under a structural dimension process that addresses the fields of environmentally concerned logistics operations. Following the state-of-the-art review, a detailed analysis of ECLO research with a special emphasis on fuzzy applications is provided. The findings clearly indicate that the fuzzy multi-criteria decision making technique is a frequently used hybrid method, whereas fuzzy sets theory and other fuzzy hybrid techniques identify a gap in the related literature. This paper provides further critical analysis and other research suggestions in order to clarify these gaps and offer additional research perspectives. This information may provide extensive data that will enable future researchers to fill these gaps within this field.
Effects of phytosterol ester-enriched low-fat milk on serum lipoprotein profile in mildly hypercholesterolaemic patients are not related to dietary cholesterol or saturated fat intake

Phytosterols (PS) are recommended to reduce LDL-cholesterol. However, the influence of cholesterol and fat intake on the lipid-lowering effect of PS in mildly hypercholesterolaemia is unclear. Thus, the aim of the present study was to evaluate whether the efficacy of PS is related to the composition of saturated fat and dietary cholesterol intake. Additionally, serum carotenoid content was analysed to evaluate to what extent it was undermined by PS. This was a 3-month randomised, parallel trial with a three-arm design. Patients were divided into three groups: healthy diet (n 24), healthy diet+PS (n 31) and free diet+PS (n 29), receiving 2 g/d of PS. Healthy and free diets were characterised by a daily ingestion of 6·8 % of saturated fat and 194·4 mg of cholesterol and 12·7 % of saturated fat and 268·1 mg of cholesterol, respectively. After PS therapy, patients receiving the healthy diet+PS or a free diet+PS exhibited a similar reduction in total cholesterol (6·7 and 5·5 %), LDL-cholesterol (9·6 and 7·0 %), non-HDL-cholesterol (12·2 and 8·9 %) and apo B-100/apo A-I ratio (11·5 and 11·6 %), respectively. In patients following the healthy diet, (β-carotene concentration rose by 26·9 %, whereas the β-carotene and lycopene levels dropped by 21·0 and 22·8 % in the group receiving the free diet+PS, respectively. No change was observed in carotenoid levels in healthy diet+PS group. In conclusion, the efficacy of PS in relation to lipoprotein profile is not influenced by saturated fat or dietary cholesterol intake, which confirms the positive effect of healthy diet therapy in improving the negative effects that PS exert on carotenoid levels.
Enhancing quality of student teachers' practices through reflective journal writing during school practice

This paper explores the role of journal writing in enhancing student teachers’ learning during school practice. It analyses data from 22 student teachers’ journals and 23 questionnaires. The study focuses on the areas that student teachers reflected on most, the nature of their reflection and the extent to which previous experiences informed their subsequent reflection and learning. Findings showed that student teachers frequently reflected on handling indiscipline issues, procedures and outcomes of supervision, but less on their own learning. Inadequate reflection on their learning suggests that journal writing has not yet sufficiently promoted student teachers’ professional growth. Generally, the examination and cultural orientation in the Ugandan society influence student teachers’ journal writing. Finally, the paper proposes strategies for improving journal writing in order to enhance the potential of students learning from reflection during school practice.
Minimal determinant expressed by a recombinant vaccinia virus elicits therapeutic antitumor cytolytic T lymphocyte responses.

Anticancer vaccine strategies can now target intracellular antigens that are involved in the process of malignant transformation, such as oncogene products or mutated tumor suppressor genes. Fragments of these antigens, generally 8-10 amino acids in length and complexed with MHC class I molecules, can be recognized by CD8+ T lymphocytes (TCD8+). To explore the possibility of using a genetically encoded, minimally sized fragment of an intracellular antigen as an immunogen, we constructed a recombinant vaccinia virus encoding an 8-residue peptide derived from chicken ovalbumin that is known to associate with the mouse H-2Kb molecule. Compared to standard methods of immunization, recombinant molecule. Compared to standard methods of immunization, recombinant vaccinia virus expressing the minimal determinant as well as full length ovalbumin were the only approaches that elicited specific primary lytic responses in C57BL/6 mice against E.G7OVA, a transfectant of the murine thymoma EL4 containing the ovalbumin gene. Stimulating these effectors in vitro with OVA257-264 peptide induced H-2Kb-restricted TCD8+ that not only lysed but also specifically secreted IFN-gamma in response to an antigen. Furthermore, when transferred adoptively, these anti-OVA257-264 TCD8+ cells significantly reduced the growth of established ovalbumin-transfected tumors in a pulmonary metastasis model system. Synthetic transfected tumors in a pulmonary metastasis model system. Synthetic oligonucleotides encoding minimal antigenic determinants within expression constructs may be a useful approach for treatment of neoplastic disease, thus avoiding the potential hazards of immunizing with full-length cDNAs that are potentially oncogenic.
An empirical model of technical debt and interest

Cunningham introduced the metaphor of technical debt as guidance for software developers that must trade engineering quality against short-term goals. We revisit the technical debt metaphor, and translate it into terms that can help IT executives better understand their IT investments. An approach is proposed to quantify debts (cost to fix technical quality issues) and interest (extra cost spent on maintenance due to technical quality issues). Our approach is based on an empirical assessment method of software quality developed at the Software Improvement Group (SIG). The core part of the technical debt calculation is constructed on the basis of empirical data of 44 systems that are currently being monitored by SIG. In a case study, we apply the approach to a real system, and discuss how the results provide useful insights on important questions related to IT investment such as the return on investment (ROI) in software quality improvement.
Motivational Factors in Learning Foreign Languages: The Case of Russian

There are two types of motivation, that is, concrete motivation (instrumental) and universal motivation (Integral) when learning languages. The student with concrete motivation possess limited objectives such as to read books that are suitable or in accordance with their proficiency, listening to the radio, watching television programmes and others. Students with universal motivation will have more global objectives, such as, they will view learning foreign languages as a prerequisite or key for acquainting them with the country origin of the language. Both types of motivation will determine the extrinsic motivation. How is the situation for the Russian language in accordance to these views? For 288 million people the Russian language is the mother language or is a second language. Apart of this, according to UNESCO, 215 million people in the world use the Russian language as a foreign language. The Russian language is one of the job and official language of the United Nations. The desire to know about the the Russian culture is another motivation to learn the language. A number of foreigners are attracted to the beauty of the sound of the Russian language. Presently, The Russian language is widely used in business. But there are intrinsic motivation to wanting to learning the language which are related with the delivery process of learning a foreign language. The choice of books which are attractive, teaching methods which are encouraging, the creative organization and maintainance of language classes which could result in the desire to continue lrearning the language is important. In this article, the author uses the results from a survey conducted at the Faculty of Language and Linguistics, University of Malaya oin April 2006 to find out student’s interests in learning this language.
Neural Dynamics of Audiovisual Synchrony and Asynchrony Perception in 6-Month-Old Infants

Young infants are sensitive to multisensory temporal synchrony relations, but the neural dynamics of temporal interactions between vision and audition in infancy are not well understood. We investigated audiovisual synchrony and asynchrony perception in 6-month-old infants using event-related brain potentials (ERP). In a prior behavioral experiment (n = 45), infants were habituated to an audiovisual synchronous stimulus and tested for recovery of interest by presenting an asynchronous test stimulus in which the visual stream was delayed with respect to the auditory stream by 400 ms. Infants who behaviorally discriminated the change in temporal alignment were included in further analyses. In the EEG experiment (final sample: n = 15), synchronous and asynchronous stimuli (visual delay of 400 ms) were presented in random order. Results show latency shifts in the auditory ERP components N1 and P2 as well as the infant ERP component Nc. Latencies in the asynchronous condition were significantly longer than in the synchronous condition. After video onset but preceding the auditory onset, amplitude modulations propagating from posterior to anterior sites and related to the Pb component of infants’ ERP were observed. Results suggest temporal interactions between the two modalities. Specifically, they point to the significance of anticipatory visual motion for auditory processing, and indicate young infants’ predictive capacities for audiovisual temporal synchrony relations.
Strongly unforgeable ID-based signatures without random oracles

In this paper, we construct a strongly unforgeable ID-based signature scheme in the standard model (or without random oracles), with five signature parameters. The signature size of our scheme is smaller than that of other schemes based on varieties of the Diffie Hellman (DH) problem or the discrete logarithm problem. The security of the scheme relies on the difficulty solving three problems related to the DH problem and a one-way isomorphism.
Mechanisms Underlying Encoding of Short-Lived Versus Durable Episodic Memories

We continuously encounter and process novel events in the surrounding world, but only some episodes will leave detailed memory traces that can be recollected after weeks and months. Here, our aim was to monitor brain activity during encoding of events that eventually transforms into long-term stable memories. Previous functional magnetic resonance imaging (fMRI) studies have shown that the degree of activation of different brain regions during encoding is predictive of later recollection success. However, most of these studies tested participants' memories the same day as encoding occurred, whereas several lines of research suggest that extended post-encoding processing is of crucial importance for long-term consolidation. Using fMRI, we tested whether the same encoding mechanisms are predictive of recollection success after hours as after a retention interval of several weeks. Seventy-eight participants were scanned during an associative encoding task and given a source memory test the same day or after ∼6 weeks. We found a strong link between regional activity levels during encoding and recollection success over short time intervals. However, results further showed that durable source memories, i.e., events recollected after several weeks, were not simply the events associated with the highest activity levels at encoding. Rather, strong levels of connectivity between the right hippocampus and perceptual areas, as well as with parts of the self-referential default-mode network, seemed instrumental in establishing durable source memories. Thus, we argue that an initial intensity-based encoding is necessary for short-term encoding of events, whereas additional processes involving hippocampal–cortical communication aid transformation into stable long-term memories.
Representing shape with a spatial pyramid kernel

The objective of this paper is classifying images by the object categories they contain, for example motorbikes or dolphins. There are three areas of novelty. First, we introduce a descriptor that represents local image shape and its spatial layout, together with a spatial pyramid kernel. These are designed so that the shape correspondence between two images can be measured by the distance between their descriptors using the kernel. Second, we generalize the spatial pyramid kernel, and learn its level weighting parameters (on a validation set). This significantly improves classification performance. Third, we show that shape and appearance kernels may be combined (again by learning parameters on a validation set). Results are reported for classification on Caltech-101 and retrieval on the TRECVID 2006 data sets. For Caltech-101 it is shown that the class specific optimization that we introduce exceeds the state of the art performance by more than 10%.