Miracle-dz/UniFAR-FTUs huggingface dataset:
UNSTEADY FLOW OF INCOMPRESSIBLE ELECTRICALLY CONDUCTING SECOND GRADE FLUID THROUGH A COMPOSITE MEDIUM IN A ROTATING PARALLEL PLATE CHANNEL BOUNDED BY A POROUS BED

In this paper, we consider the unsteady flow of an incompressible electrically conducting second grade fluid in a rigidly rotating parallel plate channel bounded below by a sparsely packed porous bed. The flow in nonporous region is governed by the equation of motion derived using the constitutive equation for the stress in compressible second order fluid, while the Brinkman’s model equation has been used for the momentum equation in the porous bed. In the undisturbed state both the fluid and the plates are in rigid rotation with same angular velocity about the normal to the plates and at t >0 the fluid is driven by the constant pressure gradient-parallel to the channel wall and in addition, the lower plate perform non-torsional oscillation in its own plane. Exact solution of the velocity in the clean fluid and the porous medium consists of steady state and transient state. The time required for the transient state to decay is evaluated and the ultimate quasi steady state solution has been derived analytically and its behaviour is computationally discussed with reference to the governing parameter. The shear stress on the boundary is obtained analytically and its behaviour is computationally discussed.
Influence of Land Use and Point Source Pollution on Water Quality in a Developed Region: A Case Study in Shunde, China

To design and implement policy to manage water quality, it is important to investigate land use and possible sources of pollution. In this study, using Pearson regression analysis, redundancy analysis and multiple regression analysis, we assess the influence of land use and point sources on water quality in the river system in Shunde district in 2000 and 2010. The results show that water quality was related positively with water surface but negatively with impervious and urban greening area. Additionally, water quality was related negatively to point source emissions of chemical oxygen demand (COD) and ammonium-nitrogen (NH4-N). The total explanatory power of spatial variation of water quality was improved from 43.4% to 60.0% in 2000 and from 31.3% to 57.8% in 2010, respectively, when the influence of point sources was added into redundancy analysis between water quality and land use. Thus, both land use management and point source pollution control should be considered for improving river water quality.
Effects of Palate Repair on Cranial Base and Maxillary Morphology in Patients With Unilateral Complete Cleft Lip and Palate

Objective: To identify the effects of palate repair on cranial base and maxillary morphology in patients with unilateral cleft lip and palate (UCLP) and to discover the relevance between cranial base and maxilla through cephalometric analysis. Design: Retrospective. Patients: Thirty-seven UCLP patients with operated lip (OL) and unoperated palate constituted OL group and were classified into 5 cervical vertebral maturation (CVM) stages. Thirty-seven UCLP patients with operated lip and palate (OLP) and 37 noncleft people with skeletal class I malocclusion were CVM- and sex-matched with the OL group as OLP group and control group, respectively. CVM stage I and II were combined into group 1, CVM stage III to V were combined into group 2. Interventions: Lateral cephalograms of all participants were obtained. Main Outcome Measures: Cephalometric analysis was employed, and data were compared among groups. Results: Length of posterior cranial base (Ba-S) of the OL group was shorter than controls in group 1; Ba-S and the ratio between length of posterior and anterior cranial base (Ba-S/S-N) of the OL and OLP groups were smaller than controls in group 2. No significant differences in cranial base were found between the OL and OLP groups. In group 1, patients of the OLP group showed smaller SNA, ANS-Ptm, and ANS-Ptm/S-N, and patients of the OL group showed smaller ANS-Ptm. In group 2, both OL and OLP groups had smaller sella-nasion-A point angle (SNA), projection distance between ANS and Ptm points on FH plane (ANS-Ptm), and the ratio between ANS-Ptm and anterior cranial base length (ANS-Ptm/S-N). Conclusions: Palate repair seems to have no obvious effects on cranial base morphology in patients with UCLP. Those patients with lip operated, whether cleft palate operated or not, tend to have a smaller length of maxilla sagittally and this deformity progresses with age.
NK Cell–Specific CDK8 Deletion Enhances Antitumor Responses

Mice with an NK cell–specific knockout of CDK8 were used to show that loss of CDK8 enhances NK-cell cytotoxicity and tumor surveillance in vivo. Thus, CDK8 is a promising target for immunotherapy against cancer. Cyclin-dependent kinase 8 (CDK8) is a member of the transcription-regulating CDK family. CDK8 activates or represses transcription by associating with the mediator complex or by regulating transcription factors. Oncogenic activity of CDK8 has been demonstrated in several cancer types. Targeting CDK8 represents a potential therapeutic strategy. Because knockdown of CDK8 in a natural killer (NK) cell line enhances cytotoxicity and NK cells provide the first line of immune defense against transformed cells, we asked whether inhibiting CDK8 would improve NK-cell antitumor responses. In this study, we investigated the role of CDK8 in NK-cell function in vivo using mice with conditional ablation of CDK8 in NKp46+ cells (Cdk8fl/flNcr1Cre). Regardless of CDK8 expression, NK cells develop and mature normally in bone marrow and spleen. However, CDK8 deletion increased expression of the lytic molecule perforin, which correlated with enhanced NK-cell cytotoxicity in vitro. This translates into improved NK cell–mediated tumor surveillance in vivo in three independent models: B16F10 melanoma, v-abl+ lymphoma, and a slowly developing oncogene-driven leukemia. Our results thereby define a suppressive effect of CDK8 on NK-cell activity. Therapies that target CDK8 in cancer patients may enhance NK-cell responses against tumor cells. Cancer Immunol Res; 6(4); 458–66. ©2018 AACR.
The relation of perceived and received social support to mental health among first responders: a meta‐analytic review

There are plenty of theories that may support the protective role of social support in the aftermath of potentially traumatic events. This meta-analytic review examined the role of received and perceived social support in promoting mental health among first responders (e.g., firefighters, police officers, and paramedics or emergency medical services personnel). Results showed that the effect sizes derived from 37 empirical studies ranged from 0 to 0.46. The overall weighted mean effect size was of medium magnitude (r=0.27). Moreover, moderator analysis showed that the effect size of perceived social support (r=0.31) was significantly higher than the effect size of received social support (r=0.22). Participants' age and gender or research design did not exert an influence on the relationship between social support and mental health. Theoretical implications and limitations are discussed. © 2010 Wiley Periodicals, Inc.
Study of the Cooling Effects of Urban Green Space in Harbin in Terms of Reducing the Heat Island Effect

The urban heat island (UHI) effect might cause extreme weather, which would seriously affect people’s health, increase energy consumption and cause other negative impacts. To construct urban green spaces is a feasible strategy to effectively weaken the UHI effect. In this study, the cooling effect of green spaces on the UHI effect was carefully investigated in summer and winter in Harbin city. Specifically, the vegetation index and surface temperature information were extracted by the grid method, and based on this data, the relationship between the urban green space and the UHI effect was analyzed quantitatively. In summer, the cooling effect is more significant. The average cooling extent reached 1.65 °C, the average maximum temperature change was 7.5 °C, and the cooling range was mainly 120 m. The cooling effect can be improved by adjusting the green space area, perimeter and shape. Increasing the green area (within 37 ha) or the green circumference (within 5300 m) can most economically improve its cooling effect. The shape factor would significantly affect the cooling effect within 0.03. The simpler the green space shape, the more obvious the cooling effect. In contrast, in winter the green spaces had a certain cooling effect when there was no snow cover or little snow cover, although this was still less significant compared with the situation in summer. The average cooling extent reached 0.48 °C, the average maximum temperature change was 4.25 °C, and the cooling range was mainly 90 m. However, there is no correlation between urban green space and the UHI effect in areas mainly covered by ice and snow. This work could provide protocols for urban green space design to effectively control the UHI effect of sub-frigid cities.
EFFECT OF DISEASE-MODIFYING ANTIRHEUMATIC DRUGS ON THE VALUES OF APOLIPOPROTEIN A-1 AND ACUTE PHASE REACTANTS IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS.

In this observational study we examined the impact of disease-modifying antirheumatic drugs (DMARDS) on the disease activity as well as the values of acute phase reactants and the apolipoprotein A1 (Apo A1) in patients with active rheumatoid arthritis (RA). Eighty patients with active RA and newly discovered RA patients who meet the American Rheumatology Association (ARA) 1987 revised criteria were treated with disease modifying anti-rheumatic drugs – DMARDs according to the standard protocol of everyday clinical practice. At 6 and 12 months of treatment the patients achieved a signifi cant decrease in the disease activity score 28 (DAS28), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) values. On the other hand, the levels of Apo A-1, which were low at baseline, were signifi - cantly higher. In conclusion, the use of DMARDs in patients with RA reduced disease activity and infl ammation, but also had a benefi cial eff ect in increasing the levels of atheroprotective Apo A-1 lipoprotein, which can reduce CV risks in these patients.
Neuroprotective effect of Citrus kawachiensis (Kawachi Bankan) peels, a rich source of naringin, against global cerebral ischemia/reperfusion injury in mice

Abstract Cerebral ischemia/reperfusion is known to induce the generation of reactive oxygen species and inflammatory responses. Numerous studies have demonstrated that naringin (NGIN) has anti-oxidant and anti-inflammatory properties. We previously reported that Citrus kawachiensis contains a large quantity of NGIN in its peel. In the present study, we orally (p.o.) administered dried peel powder of C. kawachiensis to mice of a transient global ischemia model and found in the hippocampus region that it 1) suppressed neuronal cell death, 2) reversed the reduction in the level of phosphorylated calcium-calmodulin-dependent protein kinase II, 3) had the tendency to reverse the reduction in the level of glutathione, and 4) blocked excessive activation of microglia and astrocytes. These results suggested that the dried peel powder of C. kawachiensis had a neuroprotective effect against ischemic brain via anti-oxidative and anti-inflammatory effects. We also showed that these effects of the dried peel powder were more powerful than those obtained with a comparable amount of NGIN alone. rONC-TFn had a dose-dependent cytotoxicity to the HepG2 and Hela cells and incubation of L02 cells with rONC-TFn did not result in any cytotoxicity even at very high concentrations.
Seroprevalence of Cytomegalovirus, Epstein Barr Virus and Varicella Zoster Virus among Pregnant Women in Bradford: A Cohort Study

Objective To estimate the seroprevalence of cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella zoster virus (VZV) among pregnant women in Bradford by ethnic group and country of birth. Methods A stratified random sample of 949 pregnant women enrolled in the Born in Bradford birth cohort was selected to ensure sufficient numbers of White UK born women, Asian UK born women and Asian women born in Asia. Serum samples taken at 24-28 weeks’ gestation were tested for CMV IgG, EBV IgG and VZV IgG. Each woman completed a questionnaire which included socio-demographic information. Results CMV seroprevalence was 49% among the White British women, 89% among South Asian UK born women and 98% among South Asian women born in South Asia. These differences remained after adjusting for socio-demographic factors. In contrast, VZV seroprevalence was 95% among women born in the UK but significantly lower at 90% among South Asian women born in Asia. EBV seroprevalence was 94% overall and did not vary by ethnic group/country of birth. Conclusions Although about half of White British women are at risk of primary CMV infection in pregnancy and the associated increased risk of congenital infection, most congenital CMV infections are likely to be in children born to South Asian women with non-primary infection during pregnancy. South Asian women born in South Asia are at risk of VZV infection during pregnancy which could produce congenital varicella syndrome or perinatal chickenpox. Differences in CMV and VZV seroprevalence by ethnic group and country of birth must be taken into account when universal immunisation against these viruses is contemplated.
Regional differences in the preferred e-vector orientation of honeybee ocellar photoreceptors

ABSTRACT In addition to compound eyes, honeybees (Apis mellifera) possess three single-lens eyes called ocelli located on the top of the head. Ocelli are involved in head-attitude control and in some insects have been shown to provide celestial compass information. Anatomical and early electrophysiological studies have suggested that UV and blue–green photoreceptors in ocelli are polarization sensitive. However, their retinal distribution and receptor characteristics have not been documented. Here, we used intracellular electrophysiology to determine the relationship between the spectral and polarization sensitivity of the photoreceptors and their position within the visual field of the ocelli. We first determined a photoreceptor's spectral response through a series of monochromatic flashes (340–600 nm). We found UV and green receptors, with peak sensitivities at 360 and 500 nm, respectively. We subsequently measured polarization sensitivity at the photoreceptor's peak sensitivity wavelength by rotating a polarizer with monochromatic flashes. Polarization sensitivity (PS) values were significantly higher in UV receptors (3.8±1.5, N=61) than in green receptors (2.1±0.6, N=60). Interestingly, most receptors with receptive fields below 35 deg elevation were sensitive to vertically polarized light while the receptors with visual fields above 35 deg were sensitive to a wide range of polarization angles. These results agree well with anatomical measurements showing differences in rhabdom orientations between dorsal and ventral retinae. We discuss the functional significance of the distribution of polarization sensitivities across the visual field of ocelli by highlighting the information the ocelli are able to extract from the bee's visual environment. Summary: UV-sensitive photoreceptors are more strongly polarization sensitive than green photoreceptors in honeybee ocelli; preferred e-vector orientation varies across the visual field with a preference for vertically polarized light along the equator.
Isolation and Identification of a Novel LipaseProducing Bacteria from Oil Spilled Soil

Lipases are glycerol ester hydrolases that catalyze the hydrolysis of triglycerides to free fatty acids and glycerol. Oil spilled soil samples collected from Dharmapuri and Salem districts were screened for a novel lipase producing bacteria by screening in Tributyrin agar plate and Rhodamine olive oil agar and lipase screening liquid medium. Among the two hundred isolates thirty two isolates exhibited high lipolytic activity on TBA plate assay and twenty isolate exhibited high lipolytic activity on ROA plate assay The isolate BLP 141 produces lipase more than 12 U/ml in the further lipase screening liquid medium was selected as a novel lipase producing bacteria and identified by morphological and biochemical characteristics as Pseudomonas. The 16S rRNA gene amplified by bacterial universal primer 27F and 1492R yielded 1478 bp was analysed by BLAST confirmed it as Pseudomonas gessardii and was submitted in GenBank with accession number KJ547711.
Comparative mitochondrial genome analysis of Daphnis nerii and other lepidopteran insects reveals conserved mitochondrial genome organization and phylogenetic relationships

In the present study, the complete sequence of the mitochondrial genome (mitogenome) of Daphnis nerii (Lepidoptera: Sphingidae) is described. The mitogenome (15,247 bp) of D.nerii encodes13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), two ribosomal RNA genes (rRNAs) and an adenine (A) + thymine (T)-rich region. Its gene complement and order is similar to that of other sequenced lepidopterans. The 12 PCGs initiated by ATN codons except for cytochrome c oxidase subunit 1 (cox1) gene that is seemingly initiated by the CGA codon as documented in other insect mitogenomes. Four of the 13 PCGs have the incomplete termination codon T, while the remainder terminated with the canonical stop codon. This mitogenome has six major intergenic spacers, with the exception of A+T-rich region, spanning at least 10 bp. The A+T-rich region is 351 bp long, and contains some conserved regions, including ‘ATAGA’ motif followed by a 17 bp poly-T stretch, a microsatellite-like element (AT)9 and also a poly-A element. Phylogenetic analyses based on 13 PCGs using maximum likelihood (ML) and Bayesian inference (BI) revealed that D. nerii resides in the Sphingidae family.
The Relationship Between Nursing Workload, Quality of Care, and Nursing Payment in Intensive Care Units

Background: Nursing workload is highly associated with patient safety. It has been argued that the imbalance between nursing payment and nursing workload in Taiwan National Health Insurance (NHI)-covered intensive care units (ICUs) has resulted in the inadequate allocation of nursing manpower. However, limited empirical data are currently available to support this argument. Purpose: The aim of this study was to investigate the correlation between nursing workload, quality of care, and NHI-covered nursing payments in ICU settings. Methods: This macrodata analysis study retrieved data from the existing ICU patient classification system, nursing quality monitoring system, and infection control monitoring system of a medical center in central Taiwan. Data on the Therapeutic Intervention Scoring System-28 (TISS-28) and non-TISS-28 scores, nursing hours, and nursing labor utilization rate were retrieved for the 23-month period beginning in January 2013 and ending in November 2014. The indices of care quality used in this study included incidence of falls, pressure sore density, incidence of restraint use, incidence of tube self-extraction, and infection density. Results: A total of 92,442 data sets were collected from eight ICUs, with 61% of the direct ICU nursing hours categorized as TISS-28 and 39% categorized as non-TISS-28. Mean nursing hours totaled 12.5 hours. The direct nursing hours, the total nursing hours, the bed occupancy rate, the nursing hours calculated by patient classification system, and the nursing hours calculated by nurse–patient ratio were statistically, significantly correlated respectively with all of the care quality indices except for incidence of falls. The number of items of patient care in the patient classification records was greater than that of NHI-covered nursing payments. The NHI-covered nursing payment for every patient accounted for only 4.77% of the total medical expenses in the ICU. Conclusions/Implications for Practice: Data from the patient classification database, quality monitoring database, and medical cost database indicate excessive nursing workload and underpayment from the Taiwan NHI program. Current nursing workload was significantly associated with care quality. This study provides empirical data for administrators to consider when revising nursing staffing and NHI payment policies.
The Harris hip score: Do ceiling effects limit its usefulness in orthopedics?

Background and purpose The Harris hip score (HHS), a disease-specific health status scale that is frequently used to measure the outcome of total hip arthroplasty, has never been validated properly. A questionnaire is suitable only when all 5 psychometric properties are of sufficient quality. We questioned the usefulness of the HHS by investigating its content validity. Methods We performed a systematic review based on a literature search in PubMed, Embase, and the Cochrane Library for descriptive studies published in 2007. 54 studies (59 patient groups) met our criteria and were included in the data analysis. To determine the content validity, we calculated the ceiling effect (percentage) for each separate study and we pooled data to measure the weighted mean. A subanalysis of indications for THA was performed to differentiate the populations for which the HHS would be suitable and for which it would not. A ceiling effect of 15% or less was considered to be acceptable. Results Over half the studies (31/59) revealed unacceptable ceiling effects. Pooled data across the studies included (n = 6,667 patients) suggested ceiling effects of 20% (95%CI: 18–22). Ceiling effects were greater (32%, 95%CI:12–52) in those patients undergoing hip resurfacing arthroplasty. Interpretation Although the Harris hip score is widely used in arthroplasty research on outcomes, ceiling effects are common and these severely limit its validity in this field of research.
Is Media Multitasking Good for Cybersecurity? Exploring the Relationship Between Media Multitasking and Everyday Cognitive Failures on Self-Reported Risky Cybersecurity Behaviors

Abstract The current study focused on how engaging in media multitasking (MMT) and the experience of everyday cognitive failures impact on the individual's engagement in risky cybersecurity behaviors (RCsB). In total, 144 participants (32 males, 112 females) completed an online survey. The age range for participants was 18 to 43 years (M = 20.63, SD = 4.04). Participants completed three scales which included an inventory of weekly MMT, a measure of everyday cognitive failures, and RCsB. There was a significant difference between heavy media multitaskers (HMM), average media multitaskers (AMM), and light media multitaskers (LMM) in terms of RCsB, with HMM demonstrating more frequent risky behaviors than LMM or AMM. The HMM group also reported more cognitive failures in everyday life than the LMM group. A regression analysis showed that everyday cognitive failures and MMT acted as significant predictors for RCsB. These results expand our current understanding of the relationship between human factors and cybersecurity behaviors, which are useful to inform the design of training and intervention packages to mitigate RCsB.