Miracle-dz/UniFAR-FTUs huggingface dataset:
Adding Cilostazol to Dual Antiplatelet Therapy Achieves Greater Platelet Inhibition than High Maintenance Dose Clopidogrel in Patients With Acute Myocardial Infarction: Results of the Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With AMI (ACCEL-AMI) Study

Background—Optimal platelet inhibition is an important therapeutic adjunct in patients acute myocardial infarction (AMI) undergoing coronary stenting. Whether adjunctive cilostazol to dual antiplatelet therapy (triple antiplatelet therapy) can inhibit enhanced platelet reactivity in patients with AMI yet has not been determined. The aim of this study was to assess the degree of platelet inhibition by triple antiplatelet therapy in patients with AMI. Methods and Results—Immediately after emergency room arrival, patients with AMI received clopidogrel (600-mg loading dose, followed by 75 mg daily) and aspirin (300-mg loading dose and 200 mg daily throughout the study period). After patients underwent coronary stenting (n=90), they were randomly assigned to 1 of 3 groups before discharge: standard group, clopidogrel of 75 mg daily (n=30); high maintenance dose (MD) group, clopidogrel of 150 mg daily (n=30); and triple group, adjunctive cilostazol of 100 mg twice daily to clopidogrel of 75 mg daily (n=30). Platelet reactivity was assessed at predischarge and 30-day follow-up by conventional aggregometry and the VerifyNow P2Y12 assay. Predischarge platelet reactivities were similar in the 3 groups. At 30-day follow-up, inhibition of maximal aggregation with 20 &mgr;M ADP stimuli was 6.0% in the standard group, 19.1% in the high-MD group, and 42.4% in the triple group (P<0.001), whereas inhibition of late aggregation with 20&mgr;M ADP stimuli was 10.8%, 38.1%, and 66.4%, respectively (P<0.001). Similar results were demonstrated when 5 &mgr;M ADP was used. Furthermore, percent changes of P2Y12 reaction unit were significantly different among regimens (10.6% in the standard group, 30.7% in the high-MD group, and 43.0% in the triple group; P<0.001). With respect to high-postclopidogrel platelet reactivity (prespecified as 20 &mgr;M ADP-induced maximal aggregation >50% of light transmission), fewer patients in the triple group (13.3%) met the criteria as compared with those in the standard (76.7%) and high-MD groups (56.7%) at 30-day follow-up (P<0.001). In the triple group, there were more potent and consistent platelet inhibitions by all parameters as compared with the high-MD group except for percent changes of P2Y12 reaction unit (P=0.071). Conclusions—Among patients with AMI undergoing coronary stenting, triple antiplatelet therapy results in a greater antiplatelet effect at 30 days as compared with a high-MD clopidogrel or standard dual antiplatelet therapy.
Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study.

OBJECTIVE To measure soluble factors having a possible role in fibromyalgia (FM) and compare the profiles of patients with recent onset of the syndrome with patients with chronic FM. METHODS The production of cytokines, cytokine-related molecules, and a CXC chemokine, interleukin (IL)-8, was examined. Fifty-six patients with FM (23 with <2 yr and 33 with >2 yr of symptoms) were compared with age- and sex-matched healthy controls. Cytokines and cytokine-related molecules were measured in sera and in supernatants of peripheral blood mononuclear cells (PBMC) that were incubated with and without lectins and phorbol myristate acetate (PMA). RESULTS No differences between FMS and controls were found by measuring IL-1beta, IL-2, IL-10, serum IL-2 receptor (sIL-2R), interferon gamma (IFN-gamma), and tumour necrosis factor alpha (TNF-alpha). Levels of IL-1R antibody (IL-1Ra) and IL-8 were significantly higher in sera, and IL-1Ra and IL-6 were significantly higher in stimulated and unstimulated FM PBMC compared with controls. Serum IL-6 levels were comparable to those in controls, but were elevated in supernatants of in vitro-activated PBMC derived from patients with >2 yr of symptoms. In the presence of PMA, there were additional increases in IL-1Ra, IL-8 and IL-6 over control values. CONCLUSIONS In patients with FM we found increases over time in serum levels and/or PBMC-stimulated activity of soluble factors whose release is stimulated by substance P. Because IL-8 promotes sympathetic pain and IL-6 induces hyperalgesia, fatigue and depression, it is hypothesized that they may play a role in modulating FM symptoms.
Fluctuations and bistability in a "hybrid" atomistic model for CO oxidation on nanofacets: An effective potential analysis

We analyze fluctuations in a “hybrid” atomistic model mimicking CO oxidation on nanoscale facets of metal(100) catalyst surfaces. The model incorporates a mean-field-like treatment of infinitely mobile CO, and a lattice-gas treatment of the superlattice ordering of immobile O. For an infinite system, it exhibits an Ising-type order–disorder transition for O, together with mean-field-like bistability disappearing at a cusp bifurcation. For finite systems, we use kinetic Monte Carlo simulation to study the probability distribution for the population of adsorbed species, from which bistability can be observed, together with fluctuation-induced transitions between the two stable states. An effective potential picture emerges from our analyses that can be used to quantify both the system size dependence of fluctuations and the transition rates. Thus, our hybrid atomistic model displays fluctuation behavior analogous to traditional mean-field models. This qualitative behavior can be understood by approximate tr.
Lexical competition for production in a case of nonfluent aphasia: Converging evidence from four different tasks

We report an individual with Broca's aphasia (J.H.M.), who exhibited powerful lexical context effects in word production tasks. In an adjective–noun production task (Experiment 1), J.H. M. 's production accuracy decreased as the number of adjectives in the phrase increased (e.g., curly hair vs. long curly hair). In a picture pair naming task (Experiment 2), J.H. M. 's naming accuracy was high, but her naming latencies were abnormally delayed when pairs were semantically related (e.g., goat and pig). This pattern was not observed for older controls. In a computerized Stroop task (Experiment 3), J.H. M. 's naming latencies were abnormally prolonged in the conflict condition, relative to a baseline colour naming task. This effect was far in excess of that for controls. Finally, in a blocked cyclic naming task (Experiment 4), J.H. M. 's accuracy was poorer and her latencies slower when the pictures were semantically related than when they were unrelated, and this effect built up across successive presentation cycles. It was far in excess of that exhibited by older controls. We propose that J.H. M. 's pattern of impairment across these four very different tasks suggests an impairment to a lexical control mechanism, whose normal function is to modulate the flow of activation throughout the lexical network, so as to minimize the competitive effects of nontarget lexical items.
Tweeting to save the furniture: the 2013 Australian election campaign on Twitter

Past years have seen continuing experimentation in the use of social media for political campaigning. By the time of the 2013 Australian federal election, social media of various forms had become comparatively mainstream in Australia and were widely used by members and candidates: more than 350 candidates operated Twitter accounts during the campaign, for instance. This article explores the key patterns both in how politicians and their parties campaigned on Twitter during the 2013 federal election campaign and in how the public responded to and engaged with these campaigns. It documents significant, systematic differences between the major party blocs and interprets these as reflecting the Coalition’s ‘small target’ strategy and Labor’s last-ditch attempts to ‘save the furniture’, respectively.
Yang–Baxter maps with first-degree-polynomial 2 × 2 Lax matrices

A family of non-parametric Yang–Baxter (YB) maps is constructed by re-factorization of 2 × 2 matrix polynomials of first degree. These maps are Poisson with respect to the Sklyanin bracket. For each Casimir function a parametric Poisson YB map is generated by reduction on the corresponding level set. By considering a complete set of Casimir functions symplectic multi-parametric YB maps are derived. These maps are quadrirational with explicit formulae in terms of matrix operations. Their Lax matrices are, by construction, 2 × 2 first-degree-polynomial in the spectral parameter and are classified by THE Jordan normal form of the leading term. Degenerate parametric YB maps constructed as limits of the non-degenerate ones are connected to known integrable systems on quadgraphs.
Investigating the relationship among extracurricular activities, learning approach and academic outcomes: A case study

Learning effectiveness requires an understanding of the relationship among extracurricular activities, learning approach and academic performance and, it is argued, this helps educators develop techniques designed to enrich learning effectiveness. Biggs’ Presage–Process–Product model on student learning has identified the relationship among individual difference, learning approaches and academic achievement in higher education. Studies have typically revealed that the deep approach is positively associated with academic achievement. It is argued that extracurricular activities enhance students’ confidence in their ability which in turn encourages deep learning. Comparatively little is known about such relationship. The main aims of this study are to examine the effect of the learning approach on academic outcomes and the effect of extracurricular activities on the learning approach and academic outcomes. A total of 131 full-time students participated in this research using Revised Two-Factor Study Process Questionnaire to examine the fit of the variables to hypothesised model. The results indicate a positive relationship between deep approach and academic outcomes. Students with active involvement in extracurricular activities are more likely to use the deep approach.
NO2 Detection Using Microcantilever Based Potentiometry

A highly sensitive and novel sensor platform for gases and volatile chemicals using microcantilever based potentiometry is reported. A resonant cantilever is used to detect the changes in surface work functions of functionalized substrates caused by adsorption of target gas molecules. Surface work function (SWF) changes were measured for different functionalization layers made of transition metal oxide thin films with the flow of NO2. The rate of change in SWF for In2O3 and SnO2 were found to be ∼80 and ∼100 μV/sec, respectively, for 70 ppm NO2. A sensitivity of 64 μV/sec for SWF change was also found for 70 ppm NO2 concentration for isolated clusters of ZnO nanowires, indicating that this technique is applicable even for nano-clusters of sensing materials where amperometric detection is impossible due to material discontinuity. NO2 detection as low as 400 ppb was possible using highly insulating In2O3 and SnO2 thin films (resistivity > 1 TΩ/□. Two different forms of nano scale graphite were compared with the transition oxide based functionalization layer for sensing sub-ppm NO2 sensing. It was observed that nanostructured graphite (NG) shows much higher sensitivity and lower response time than transition metal oxides.
The molecular pathogenesis of small cell lung cancer

Small cell lung cancer (SCLC) represents 13% of all lung cancer cases diagnosed in the United States. Although a chemotherapy- and radiation-sensitive disease, SCLC recurs rapidly with only 5% of patients surviving five years. This dismal prognosis likely is secondary to few improvements in its treatment, without significant changes in its standard of care over the last three decades. SCLC has a unique biology with specific molecular and cellular changes, which are the subject of active investigation. Here, we summarize the alterations leading to the pathogenesis of SCLC: chromosomal changes; dysregulation of tumor suppressor genes, oncogenes, and signaling pathways; upregulation of receptor tyrosine kinases, growth factors, and cellular markers; and the persistence of developmental pathways. Each of these represents potential targets for therapy and many biologic agents are being studied.
Bone mineral density in patients with rheumatoid arthritis: relation between disease severity and low bone mineral density

Objective: To examine variables associated with bone mineral density (BMD) in patients with rheumatoid arthritis (RA). Methods: We investigated 373 patients with low to moderately active RA. Patients with low disease activity were recruited from a cohort of patients in clinical remission. Patients with moderately active disease were included in a trial comparing the effects of long term high intensity exercise programme and conventional physical therapy. Demographic and clinical data were collected. Bone mineral density (BMD) was measured by means of dual x ray absorptiometry (DXA). Associations between demographic and clinical measurements on the one hand and BMD on the other were investigated in regression analyses. Results: The patient group consisted of middle aged, mainly female, patients. The median (interquartile range) disease duration was 7 (4 to 13) years, the mean disease activity score (standard deviation) was 3.2 (1.4). Of the group, 66% was rheumatoid factor positive, and 83% (n = 304) had never used corticosteroids. The median Larsen score of hands and feet was 27 (5 to 61). Greater age and low body mass index were related to low BMD at the hip and spine. High Larsen score for hands and feet was significantly associated with low BMD at the hip. The use of corticosteroids was not independently associated with BMD. The results of the multiple regression analyses also applied to the subgroup of corticosteroid naive patients. Conclusion: BMD data of patients with low to moderately active RA demonstrated an association between high radiological RA damage and low BMD at the hip, which suggests an association between the severity of RA and the risk of generalised bone loss, which also occurred in corticosteroid naive patients.
Towards A Wider Application of the Systems Approach in Information Systems and Software Engineering

The chapter provides possible directions for the wider application of the systems approach to information systems development. Potential improvement of software development practices is linked by some leading experts to the application of more systemic ideas. However, the current state of the practice in software engineering and information systems development shows the urgent need for improvement through greater application of systems thinking.
the PHSCN Sequence in Prostate Carcinoma Anti-invasive , Antitumorigenic , and Antimetastatic Activities of Updated Version

Using naturally serum-free SU-ECM basement membranes as invasion substrates showed that plasma fibronectin was necessary to stimulate invasion by DU 145 human and metastatic MATLyLu (MLL) rat prostate carcinoma cells. This activity mapped to the PHSRN sequence, which induced invasion througha5b1 integrin. PHSCN, a competitive inhibitor, blocked both PHSRNand serum-induced invasion. Acetylated, amidated PHSCN (Ac-PHSCN-NH2) was 30-fold more potent; however, AcHSPNC-NH2 was inactive. Rats receiving injections s.c. with 100,000 MLL cells were treated systemically by i.v. injection three times weekly with 1 mg of either Ac-PHSCN-NH2 or Ac-HSPNC-NH2 beginning 24 h later, three times weekly with 1 mg of Ac-PHSCN-NH2 beginning only after surgery to remove large (2 cm) MLL tumors, or were left untreated. MLL tumors grew rapidly in Ac-HSPNC-NH2-treated and in untreated rats. MLL tumor growth in rats treated with Ac-PHSCN-NH 2 beginning 1 day after MLL cell injection was reduced by 99.9% during the first 16 days of treatment, although subsequent tumor growth occurred. MLL tumor cryosections immunostained with anti-PECAM-1 showed that AcPHSCN-NH2 inhibited neovascularization by 12-fold during this time. Whether initiated after MLL cell injection or only after MLL tumor removal, Ac-PHSCN-NH2 treatment reduced the numbers of MLL lung colonies and micrometastases by 40to >100-fold, whereas Ac-HSPNCNH2 was inactive. Thus, Ac-PHSCN-NH2 may be a potent antitumorigenic and antimetastatic agent for postsurgical use prior to extensive metastasis.
Use of viscoelastic substance in ophthalmic surgery – focus on sodium hyaluronate

Among viscoelastic substances, sodium hyaluronate has become the most popular for intraocular surgeries since the introduction of Healon® (sodium hyaluronate 1%, 4 × 106 daltons) in 1979. This review focuses on the recent development of a new generation of sodium hyaluronate agents with new rheologic properties and the relevant new techniques used in cataract, glaucoma, corneal, and vitreoretinal surgeries. The introduction of sodium hyaluronate agents with different rheologic properties has improved the safety and reliability of intraocular surgeries. Although there have been numerous studies reporting the effectiveness of viscoelastic substances in intraocular surgeries, rigorous validation by multi-center randomized control trials is lacking in many cases. At present, no single viscoelastic agent is most suitable to all of the various intraocular surgical techniques. Therefore, ophthalmologic surgeons should keep up with recent developments of viscoelastic agents and relevant surgical techniques for better patient care.
Influence of organizational rewards on organizational commitment and turnover intentions

Purpose – The purpose of this paper is to explore the relationship between extrinsic, intrinsic and social rewards and two components of organizational commitment and finally Chinese workers turnover intention in public and private sector. Design/methodology/approach – A questionnaire was utilized as the method for data collection. Structural equation modeling was utilized to examine survey data obtained from 202 employees in the southern part of China. Findings – The findings exhibit that extrinsic, social and intrinsic rewards were significantly related to affective and normative commitment. Findings suggest that satisfaction with extrinsic benefits, supervisor support, coworker support, autonomy, training and participation in decision making has substantial impact on employee’s affective and normative commitment. However, affective and normative commitment was negatively related to employee turnover intention. Research limitations/implications – This study covers different public and private-sector org.
Investigation The Role of Gender on The HLA-DRB1 and -DQB1 Association with Type 1 Diabetes Mellitus in Iranian Patients

Objective: Type 1 diabetes mellitus (T1D) is an autoimmune and multifactorial disorder. Subsequent analysis on human leukocyte antigen ( HLA) region shows that HLA-DRB1 and -DQB1 genes have the strongest association with T1D. In this study, for the first time, we investigated the influence of gender on the HLA-DRB1 and -DQB1 association with type 1 diabetes mellitus in Iranian patients in order to determine gender dependent HLA heterogeneity in Iranian T1D patients. Materials and Methods: In this case control study, the HLA-DRB1 and -DQB1 typing were performed on 105 Iranian T1D patients and 100 healthy controls. The data were evaluated by using Fisher exact test. Results: Our results indicate that DRB1*04:01, DQB1*03:02 alleles and DRB1*04:01- DQB1*03:02 haplotype were significantly more frequent in male T1D patients than females. Also, DRB1*03:01, DRB1*15:01, DQB1*06:01 alleles, DQB1*03:01/05:01 genotype, DRB1*03:01-DQB1*02:01 and DRB1*15:01-DQB1*06:01 haplotypes were significantly higher in female T1D group than males. Furthermore, our results showed that DRB1*04:01 and DQB1*03:02 alleles were significantly more frequent in male T1D patients 1-5 years old at onset than females with similar condition. The DRB1*03:01 allele and DRB1*03:01- DQB1*02:01 haplotype were significantly higher in female T1D patients 6-10 years old at onset than males with similar condition. The DRB1*15:01 allele and DRB1*15:01-DQB1*06:01 haplotype were significantly more frequent in female T1D patients 16-20 years old at onset than males with similar condition. Conclusion: Our findings suggest that gender has a significant influence on the distribution of HLA-DR and -DQ alleles, genotypes and haplotypes. Also, distribution of the HLA-DRB1 and -DQB1 alleles, genotypes and haplotypes vary based on the gender of T1D patients in different age at onset.
Testing of a paper-and-pencil Personalized Single Category Implicit Association Test (SC-IAT-P)

The purpose of this series of studies is to test a paper-and-pencil procedure adapted from a computerized Implicit Association Test: the SC-IAT-P (Personalized Single Category Implicit Association Test, Bardin, et al. 2014). This adaptation combines the advantages of SC-IAT (Karpinski & Steinman, 2006), IAT-P (Olson & Fazio, 2004) and paper-and-pencil IAT (Lemm, Lane, Sattler, Khan & Nosek, 2008). It is capable of measuring implicit attitude toward a single object, limits the influence of extrapersonal associations, and is unquestionably easy to administer. The tool was used in three studies with two different goals. Study 1 highlights a link between paper-and-pencil SC-IAT-P and a computerized corollary in the field of tobacco-smoking. Study 2 reveals the ability of the tool to distinguish smokers from non-smokers according to their score and smokers who have already considered quitting from those who have never considered it. Finally, Study 3, carried out between the two rounds of the French presidential elections in 2012, highlights the difference of attitude between supporters on the Left and Right but also an effect of indecision. The discussion deals with the prospects offered by this tool and its limitations. Resume : Cette serie d’etudes teste une adaptation en procedure papier crayon d’un test d’association implicite informatise : le SC-IAT-P (Single Category Implicit Association Test Personalized, Bardin, Perrissol, Py, Launay, & Escoubes, 2014). Cette adaptation allie les avantages du SC-IAT (Karpinski & Steinman, 2006) de l’IAT-P (Olson & Fazio, 2004) et de l’IAT format papier crayon (Lemm, Lane, Sattler, Khan, & Nosek, 2008). Il mesure l’attitude implicite envers un unique objet, limite la contamination de la mesure par des associations extra-personnelles et son administration est d’une facilite indeniable. L’outil a ete mis en oeuvre dans trois etudes portant sur deux objets. L’etude 1 permet de mettre en evidence un lien entre le SC-IAT-P papier crayon et son corollaire informatise dans le domaine du tabac. L’etude 2 revele la capacite de l’outil a discriminer les fumeurs des non-fumeurs en fonction de leur score au SC-IAT-P papier crayon mais egalement les fumeurs qui ont deja envisage d’arreter de fumer de ceux qui n’ont jamais envisage. Enfin, l’etude 3, realisee pendant l’entre deux tours des elections presidentielles francaises de 2012, met en evidence une difference d’attitude entre les sympathisants de gauche et de droite mais egalement un effet de l’indecision. La discussion porte notamment sur les perspectives offertes par cet outil et ses limites.
Destination Choice Models for Rock Climbing in the Northeastern Alps: A Latent-Class Approach Based on Intensity of Preferences

Rock climbers are likely to exhibit preference heterogeneity dictating the way with which such sport is practiced. This has a reflection on the population’s structure of recreational values of rock-climbing destinations, their attributes, and to land management policies. We test this hypothesis on a panel of destination choices by a sample of members of the Italian Alpine Club. Using a latent-class, random utility approach we find evidence in support of the hypothesis that there are at least four classes in the sample, thereby revealing a considerable richness in the structure of preference, which would otherwise be unobservable with more conventional approaches. (JEL Q26, C25)