Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Negative Affect on Headache‐Related Disability Following Traumatic Physical Injury

Acute postinjury negative affect (NA) may contribute to headache pain following physical injury. Early psychiatric–headache comorbidity conveys increased vulnerability to chronic headache‐related disability and impairment. Yet, it is unknown whether NA is involved in the transition to chronic headache related‐disability after injury. This prospective observational study examined the role of acute postinjury NA on subacute and chronic headache‐related disability above and beyond nonpsychiatric factors.
The Old Host-galaxy Environment of SSS17a, the First Electromagnetic Counterpart to a Gravitational-wave Source

We present an analysis of the host-galaxy environment of Swope Supernova Survey 2017a (SSS17a), the discovery of an electromagnetic counterpart to a gravitational-wave source, GW170817. SSS17a occurred 1.9 kpc (in projection; 10.″2) from the nucleus of NGC 4993, an S0 galaxy at a distance of 40 Mpc. We present a Hubble Space Telescope (HST) pre-trigger image of NGC 4993, Magellan optical spectroscopy of the nucleus of NGC 4993 and the location of SSS17a, and broadband UV-through-IR photometry of NGC 4993. The spectrum and broadband spectral-energy distribution indicate that NGC 4993 has a stellar mass of log ( M / M ⊙ ) = 10.49 − 0.20 + 0.08 and star formation rate of 0.003 M ⊙ yr−1, and the progenitor system of SSS17a likely had an age of >2.8 Gyr. There is no counterpart at the position of SSS17a in the HST pre-trigger image, indicating that the progenitor system had an absolute magnitude M V > − 5.8 mag. We detect dust lanes extending out to almost the position of SSS17a and >100 likely globular clusters associated with NGC 4993. The offset of SSS17a is similar to many short gamma-ray-burst offsets, and its progenitor system was likely bound to NGC 4993. The environment of SSS17a is consistent with an old progenitor system such as a binary neutron star system.
Impact of chronic maternal stress during early gestation on maternal–fetal stress transfer and fetal stress sensitivity in sheep

Abstract Acute stress-induced reduction of uterine blood flow (UBF) is an indirect mechanism of maternal–fetal stress transfer during late gestation. Effects of chronic psychosocial maternal stress (CMS) during early gestation, as may be experienced by many working women, on this stress signaling mechanism are unclear. We hypothesized that CMS in sheep during early gestation augments later acute stress-induced decreases of UBF, and aggravates the fetal hormonal, cardiovascular, and metabolic stress responses during later development. Six pregnant ewes underwent repeated isolation stress (CMS) between 30 and 100 days of gestation (dGA, term: 150 dGA) and seven pregnant ewes served as controls. At 110 dGA, ewes were chronically instrumented and underwent acute isolation stress. The acute stress decreased UBF by 19% in both the CMS and control groups (p < .05), but this was prolonged in CMS versus control ewes (74 vs. 30 min, p < .05). CMS increased fetal circulating baseline and stress-induced cortisol and norepinephrine concentrations indicating a hyperactive hypothalamus–pituitary–adrenal (HPA)-axis and sympathetic–adrenal–medullary system. Increased fetal norepinephrine is endogenous as maternal catecholamines do not cross the placenta. Cortisol in the control but not in the CMS fetuses was correlated with maternal cortisol blood concentrations; these findings indicate: (1) no increased maternal–fetal cortisol transfer with CMS, (2) cortisol production in CMS fetuses when the HPA-axis is normally inactive, due to early maturation of the fetal HPA-axis. CMS fetuses were better oxygenated, without shift towards acidosis compared to the controls, potentially reflecting adaptation to repeated stress. Hence, CMS enhances maternal–fetal stress transfer by prolonged reduction in UBF and increased fetal HPA responsiveness.
On the persistence regime for Lotka-Volterra in randomly fluctuating environments

In this note, we study the long time behavior of Lotka-Volterra systems whose coefficients vary randomly. Bena{\"i}m and Lobry (2015) recently established that randomly switching between two environments that are both favorable to the same species may lead to different regimes: extinction of one species or the other, or persistence of both species. Our purpose here is to describe more accurately the range of parameters leading to these regimes, and the support of the invariant probability measure in case of persistence.
Dietary oils and FADS 1-FADS 2 genetic variants modulate [ 13 C ] a-linolenic acid metabolism and plasma fatty acid composition 1 – 5

Background: Desaturation of dietary a-linolenic acid (ALA) to omega-3 (n23) long-chain fatty acids (FAs) is mediated through FA desaturases (FADS1-FADS2) and may be influenced by dietary FA composition. Objective: We investigated the effects of diets enriched in flaxseed oil (FXCO) or high–oleic acid canola oil (HOCO) compared with a Western diet (WD) and FADS1-FADS2 single nucleotide polymorphisms (SNPs) on plasma FAs and [U-C]ALA metabolism. Design: In a randomized crossover design, 36 hyperlipidemic subjects consumed 3 isoenergetic diets enriched in FXCO (20.6 g ALA/d), HOCO (2.4 g ALA/d), or WD (1.3 g ALA/d) for 4 wk. On day 27, blood was sampled 0, 24, and 48 h after the subjects (n = 26) consumed 45 mg [U-C]ALA. The subjects were genotyped for 4 FADS SNPs. Results: FXCO increased (P , 0.001) plasma ALA, EPA, and docosapentaenoic acid (DPA), with no change in DHA compared with the HOCO or WD diets. At 24 and 48 h, [U-C]ALA recovered as plasma [C]EPA and [C]DPA were lower (P , 0.001) after the FXCO diet than after the HOCO and WD diets. No change in [C]DHA was observed between diets. Minor allele homozygotes of rs174545, rs174583, rs174561, and rs174537 had lower (P , 0.05) plasma EPA, arachidonic acid (AA), EPA/ALA, and AA/linoleic acid compositions and lower (P , 0.05) plasma [C]EPA enrichment at 24 and 48 h in comparison with carriers of the major allele after all diets. SNPs were not associated with plasma composition of DHA or [C]DHA enrichment. Conclusion: An increase in ALA intake resulting in increased plasma EPA composition may be cardioprotective, especially in minor allele homozygotes. This trial was registered at www.clinicaltrials. gov as NCT00927199. Am J Clin Nutr 2013;97:195–207.
Occlusion Aware Unsupervised Learning of Optical Flow

It has been recently shown that a convolutional neural network can learn optical flow estimation with unsupervised learning. However, the performance of the unsupervised methods still has a relatively large gap compared to its supervised counterpart. Occlusion and large motion are some of the major factors that limit the current unsupervised learning of optical flow methods. In this work we introduce a new method which models occlusion explicitly and a new warping way that facilitates the learning of large motion. Our method shows promising results on Flying Chairs, MPI-Sintel and KITTI benchmark datasets. Especially on KITTI dataset where abundant unlabeled samples exist, our unsupervised method outperforms its counterpart trained with supervised learning.
Performance of Dental Hygiene Students in Mass Fatality Training and Radiographic Imaging of Dental Remains.

PURPOSE Mass fatality incidents can overwhelm local, state and national resources quickly. Dental hygienists are widely distributed and have the potential to increase response teams' capacity. However, appropriate training is required. The literature is void of addressing this type of training for dental hygienists and scant in dentistry. Hence, the purpose of this study was to assess one facet of such training: Whether the use of multimedia is likely to enhance educational outcomes related to mass fatality training. METHODS A randomized, double-blind, pre- and post-test design was used to evaluate the effectiveness of comparable educational modules for 2 groups: a control group (n=19) that received low media training and a treatment group (n=20) that received multimedia training. Participants were second-year, baccalaureate dental hygiene students. Study instruments included a multiple-choice examination, a clinical competency-based radiology lab scored via a standardized rubric, and an assessment of interest in mass fatality education as a specialty. ANOVA was used to analyze results. RESULTS Participants' pre- and post-test scores and clinical competency-based radiology lab scores increased following both educational approaches. Interest in mass fatality training also increased significantly for all participants (p=0.45). There was no significant difference in pre- and post-test multiple choice scores (p=0.6455), interest (p=0.9133) or overall competency-based radiology lab scores (p=0.997) between groups. CONCLUSION Various educational technique may be effective for mass fatality training. However, mass fatality training that incorporates multimedia is an appropriate avenue for training instruction. Continued research about multimedia's role in this specialty area is encouraged.
PerM: efficient mapping of short sequencing reads with periodic full sensitive spaced seeds

Motivation: The explosion of next-generation sequencing data has spawned the design of new algorithms and software tools to provide efficient mapping for different read lengths and sequencing technologies. In particular, ABI's sequencer (SOLiD system) poses a big computational challenge with its capacity to produce very large amounts of data, and its unique strategy of encoding sequence data into color signals. Results: We present the mapping software, named PerM (Periodic Seed Mapping) that uses periodic spaced seeds to significantly improve mapping efficiency for large reference genomes when compared with state-of-the-art programs. The data structure in PerM requires only 4.5 bytes per base to index the human genome, allowing entire genomes to be loaded to memory, while multiple processors simultaneously map reads to the reference. Weight maximized periodic seeds offer full sensitivity for up to three mismatches and high sensitivity for four and five mismatches while minimizing the number random hits per query, significantly speeding up the running time. Such sensitivity makes PerM a valuable mapping tool for SOLiD and Solexa reads. Availability: http://code.google. com/p/perm/ Contact: tingchen@usc.edu Supplementary information: Supplementary data are available at Bioinformatics online.
Protease-Mediated Suppression of DRG Neuron Excitability by Commensal Bacteria

Peripheral pain signaling reflects a balance of pronociceptive and antinociceptive influences; the contribution by the gastrointestinal microbiota to this balance has received little attention. Disorders, such as inflammatory bowel disease and irritable bowel syndrome, are associated with exaggerated visceral nociceptive actions that may involve altered microbial signaling, particularly given the evidence for bacterial dysbiosis. Thus, we tested whether a community of commensal gastrointestinal bacteria derived from a healthy human donor (microbial ecosystem therapeutics; MET-1) can affect the excitability of male mouse DRG neurons. MET-1 reduced the excitability of DRG neurons by significantly increasing rheobase, decreasing responses to capsaicin (2 μm) and reducing action potential discharge from colonic afferent nerves. The increase in rheobase was accompanied by an increase in the amplitude of voltage-gated K+ currents. A mixture of bacterial protease inhibitors abrogated the effect of MET-1 effects on DRG neuron rheobase. A serine protease inhibitor but not inhibitors of cysteine proteases, acid proteases, metalloproteases, or aminopeptidases abolished the effects of MET-1. The serine protease cathepsin G recapitulated the effects of MET-1 on DRG neurons. Inhibition of protease-activated receptor-4 (PAR-4), but not PAR-2, blocked the effects of MET-1. Furthermore, Faecalibacterium prausnitzii recapitulated the effects of MET-1 on excitability of DRG neurons. We conclude that serine proteases derived from commensal bacteria can directly impact the excitability of DRG neurons, through PAR-4 activation. The ability of microbiota-neuronal interactions to modulate afferent signaling suggests that therapies that induce or correct microbial dysbiosis may impact visceral pain. SIGNIFICANCE STATEMENT Commercially available probiotics have the potential to modify visceral pain. Here we show that secretory products from gastrointestinal microbiota derived from a human donor signal to DRG neurons. Their secretory products contain serine proteases that suppress excitability via activation of protease-activated receptor-4. Moreover, from this community of commensal microbes, Faecalibacterium prausnitzii strain 16-6-I 40 fastidious anaerobe agar had the greatest effect. Our study suggests that therapies that induce or correct microbial dysbiosis may affect the excitability of primary afferent neurons, many of which are nociceptive. Furthermore, identification of the bacterial strains capable of suppressing sensory neuron excitability, and their mechanisms of action, may allow therapeutic relief for patients with gastrointestinal diseases associated with pain.
Identification of factors affecting colostrum quality of dairy Lacaune ewes assessed with the Brix refractometer

In this Research Communication we assessed factors affecting colostrum quality of dairy Lacaune ewes using the Brix-refractometer. Colostrum from 536 lambings from one commercial intensive dairy Lacaune farm were analysed for the following factors with potential influence in colostrum quality: (1) ewe parity (n = 84–132), (2) length of previous dry period (PDP) (n = 23–214), (3) age at first lambing (AFL) of primiparous ewes (n = 9–88), (4) lambing season (n = 192 or 344), and (5) year (2011–2013, n = 142–203). Parity significantly affected colostrum quality, with primiparous ewes showing the highest Brix refractometer values (22·6 ± 5·6%, P < 0·0001), though values were similar among multiparous ewes. PDP length also significantly affected colostrum quality: ewes with the shortest PDP showed the worst quality (16·8 ± 4·2%, P < 0·0001), with quality gradually rising with PDP length. Colostrum quality was significantly higher in 2011 (21·0 ± 5·2%) than in 2012 or 2013 (P < 0·0001); this likely reflects the several-fold greater proportion of animals with long PDP in 2011. In contrast, neither AFL nor lambing season significantly affected colostrum quality. These results suggest that parity and PDP length can substantially affect ovine colostrum quality of dairy ewes under intensive management conditions and they further show the usefulness of the Brix refractometer for providing a rough estimation of colostrum quality on-farm. However, further studies are needed to determine a validated cut-off Brix value for identifying good-quality colostra in ovine species.
Fitness costs associated with Cry1F resistance in the European corn borer

Crops producing insecticidal toxins derived from the bacterium Bacillus thuringiensis (Bt) are widely planted to manage insect pests. Bt crops can provide an effective tool for pest management; however, the evolution of Bt resistance can diminish this benefit. The European corn borer, Ostrinia nubilalis Hübner, is a significant pest of maize and is widely managed with Bt maize in the Midwest of the United States. When Bt crops are grown in conjunction with non‐Bt refuges, fitness costs of Bt resistance can delay the evolution of resistance. Importantly, fitness costs often vary with ecological factors, including host‐plant genotype and diapause. In this study, we examined fitness costs associated with Cry1F resistance in O. nubilalis when insects were reared on three maize lines. Fitness costs were tested in two experiments. One experiment assessed the fitness costs when Cry1F‐resistant and Cry1F‐susceptible insects were reared on plants as larvae and experienced diapause. The second experiment tested resistant, susceptible and F1 heterozygotes that were reared on plants but did not experience diapause. Despite some evidence of greater adult longevity for Cry1F‐resistant insects, these insects produced fewer fertile eggs than Cry1F‐susceptible insects, and this occurred independent of diapause. Reduced fecundity was not detected among heterozygous individuals, which indicated that this fitness cost was recessive. Additionally, maize lines did not affect the magnitude of this fitness cost. The lower fitness of Cry1F‐resistant O. nubilalis may contribute to the maintenance of Cry1F susceptibility in field populations more than a decade after Cry1F maize was commercialized.
Efficient Tag Identification in Blocker-Assisted RFID Systems

In RFID systems, the privacy problem has attracted increasing attention as the tags have extremely limited on-chip resources and may blindly respond to unauthorized readers. To protect the privacy, one widely used solution is to deploy one or more blocker tags to collide the RF signal sent from protected tags all the time. In this paper, we investigate the problem of tag identification in privacy-sensitive RFID systems when we have the authorized reader(s). Due to the presence of blocker tags, the tag identification becomes more challenging since the protected tags and blocker tags will always respond concurrently, leading to unreconciled collisions. To overcome this challenge, we in this paper propose two efficient tag identification protocols IIP and SIP, which meet three application requirements: privacy, accuracy, and efficiency. IIP iteratively deactivates blocking tags as well as labeling genuine tags, and finally identifies tags by avoiding all the unreconciled collisions. On top of IIP, SIP further avoids the slot waste by carrying out a filter to separate genuine tags from others in advance. Simulation results demonstrate that our protocols are able to guarantee any identification accuracy in a time-efficient and privacy-protected way.
Understanding mobile IM continuance usage from the perspectives of network externality and switching costs

Retaining users and facilitating their continuance usage are essential for mobile service providers to increase both revenues and profits. This research integrates the perspectives of network externality and switching costs to propose a model for investigating the continuance usage of mobile instant messaging services. Network externality arises from both direct and indirect sources and is conceptualised as referent network size and perceived complementarity, respectively. The results show that perceived complementarity is the main factor affecting perceived enjoyment, whereas referent network size has a strong effect on perceived usefulness. Switching costs is the main factor determining switching barriers. Perceived usefulness, perceived enjoyment and switching barriers determine continuance usage.
Psychosocial Risk and Protective Factors and Incident Mild Cognitive Impairment and Dementia in Community Dwelling Elderly: Findings from the Singapore Longitudinal Ageing Study.

BACKGROUND Indicators of social isolation or support such as living alone, loneliness, being married, and life satisfaction are possible psychosocial risk and protective factors for dementia. OBJECTIVE We investigate the associations of these overlapping psychosocial factors with incident MCI-dementia (neurocognitive disorder) in a population cohort. METHODS Using data from 1601 participants of the Singapore Longitudinal Ageing Study (SLAS) who were free of MCI or dementia at baseline and followed up to 8 years, we estimated hazards ratio (HR) of association of living alone, loneliness, being married, and high life satisfaction with incident MCI-dementia. RESULTS In univariate analyses, individual HRs of association with incident MCI-dementia for living alone was 1.86 [1.18 - 2.95], (p = 0.008), loneliness was 1.26 [0.86 - 1.84], (p = 0.23), being married was 0.54 [0.39 - 0.75] (p < 0.0001), and being very satisfied with life was 0.59 [0.38-0.91]), (p = 0.017). Adjusted mutually for other psychosocial variables, and for age, sex, education, ethnicity, smoking, alcohol, dyslipidemia, hypertension, diabetes, central obesity, history of stroke or heart disease, APOE-ɛ4, depression, physical, social, and productive activities, only being married (0.68 [0.47-0.99], p = 0.044), and being very satisfied with life (0.61 [0.39 - 0.96], p = 0.034) remained significant variables associated with lower risks of developing MCI-dementia. CONCLUSION Individuals who were married and those who were very satisfied with life are protected against the risk of developing MCI and dementia. Controlling for the adverse effects of being without spousal support and low life satisfaction, living alone or a feeling of loneliness were not associated with increased risk of MCI-dementia.
Improving Biometric-Based Authentication Schemes with Smart Card Revocation/Reissue for Wireless Sensor Networks

User authentication in wireless sensor networks is more difficult than in traditional networks owing to sensor network characteristics such as unreliable communication, limited resources, and unattended operation. For these reasons, various authentication schemes have been proposed to provide secure and efficient communication. In 2016, Park et al. proposed a secure biometric-based authentication scheme with smart card revocation/reissue for wireless sensor networks. However, we found that their scheme was still insecure against impersonation attack, and had a problem in the smart card revocation/reissue phase. In this paper, we show how an adversary can impersonate a legitimate user or sensor node, illegal smart card revocation/reissue and prove that Park et al.’s scheme fails to provide revocation/reissue. In addition, we propose an enhanced scheme that provides efficiency, as well as anonymity and security. Finally, we provide security and performance analysis between previous schemes and the proposed scheme, and provide formal analysis based on the random oracle model. The results prove that the proposed scheme can solve the weaknesses of impersonation attack and other security flaws in the security analysis section. Furthermore, performance analysis shows that the computational cost is lower than the previous scheme.
Halving of the northern wetland CH4 source by a large Icelandic volcanic eruption

[1] Northern temperate and high-latitude wetlands are a major source of the greenhouse gas methane (CH4). Here, we estimate the sensitivity in the strength of this source to the effects of large Icelandic volcanic eruptions such as the Laki eruption of 1783–1784. We applied spatially explicit modeled sulfate aerosol and S deposition fields from a Laki eruption simulation to a climate-sensitive model of CH4 emissions from wetlands. We estimate that the combined influence on climate and S deposition from the Laki eruption halved the output of CH4 from wetlands north of 30°N for the first 12 months following the eruption. The largest short-term component responsible for the CH4 suppression is the aerosol-influenced surface cooling, although the effect of large-scale S deposition on CH4 emissions provides a longer-term suppressive effect on emissions. Together, we estimate this combination of processes to result in an annual suppression of ∼20 Tg CH4 in the year of the eruption and two subsequent years. Further, the impact of the eruption on atmospheric CH4 concentration extends beyond the likely duration of suppressed emission. The modeled effect of this large Icelandic eruption is consistent with ice core records of atmospheric CH4 concentrations at the time and is equivalent, in size, to the current estimated suppressive effect of industrially derived S pollution on the global wetland CH4 source.