Miracle-dz/UniFAR-FTUs huggingface dataset:
Spectral and Polarization Signatures of Relativistic Shocks in Blazars

Relativistic shocks are one of the most plausible sites of the emission of strongly variable, polarized multi-wavelength emission from relativistic jet sources such as blazars, via the diffusive shock acceleration (DSA) of relativistic particles. This paper summarizes recent results on a self-consistent coupling of diffusive shock acceleration and radiation transfer in blazar jets. We demonstrate that the observed spectral energy distributions (SEDs) of blazars strongly constrain the nature of hydromagnetic turbulence responsible for pitch-angle scattering by requiring a strongly energy-dependent pitch-angle mean free path. The prominent soft X-ray excess (“Big Blue Bump”) in the SED of the BL Lac object AO 0235+164 can be modelled as the signature of bulk Compton scattering of external radiation fields by the thermal electron population, which places additional constraints on the level of hydromagnetic turbulence. It has further been demonstrated that internal shocks propagating in a jet pervaded by a helical magnetic field naturally produce polarization-angle swings by 180 ∘ , in tandem with multi-wavelength flaring activity, without requiring any helical motion paths or other asymmetric jet structures. The specific application of this model to 3C279 presents the first consistent simultaneous modeling of snap-shot SEDs, multi-wavelength light curves, and time-dependent polarization signatures of a blazar during a polarization-angle (PA) rotation. This model has recently been generalized to a lepto-hadronic model, in which the high-energy emission is dominated by proton synchrotron radiation. It is shown that in this case, the high-energy (X-ray and γ-ray) polarization signatures are expected to be significantly more stable (not showing PA rotations) than the low-energy (electron-synchrotron) signatures.
Making MLSD decisions by thresholding the matched filter output

This paper presents an iterative detector that, by thresholding the output of the matched filter, gives maximum-likelihood sequence detector (MLSD) decisions on binary, antipodally modulated symbols that have been corrupted by intersymbol interference and additive Gaussian noise. The detector will make decisions on some, but often not all, of the symbols in a transmitted sequence, and those decisions will be the same decisions as the MLSD would have made. The number of symbols that are detected is stochastic, varying from sequence to sequence. The basis of the detector is a bound on a crossterm of the quadratic form in the log-likelihood function for the transmitted sequence. The detector is simple in structure, consisting of a matched filter and two variable threshold values for each symbol.
An Examination of the Relationship between Lipid Levels and Associated Genetic Markers across Racial/Ethnic Populations in the Multi-Ethnic Study of Atherosclerosis

Large genome-wide association studies have reported hundreds of genetic markers associated with lipid levels. However, the discovery and estimated effect of variants at these loci, derived from samples of exclusively European descent, may not generalize to the majority of the world populations. We examined the collective strength of association among these loci in a diverse set of U.S. populations from the Multi-Ethnic Study of Atherosclerosis. We constructed a genetic risk score for each lipid outcome based on previously identified lipid-associated genetic markers, and examined the relationship between the genetic risk scores and corresponding outcomes. We discover this relationship was often moderated by race/ethnicity. Our findings provide insight into the generalizability and predictive utility of large sample size meta-analyses results when leveraging data from a single population. We hope these findings will encourage researchers to investigate genetic susceptibility in more diverse populations and explore the source of such discrepancies. Until then, we caution clinicians, genetic counselors, and genetic testing consumers when interpreting genetic data on complex traits.
Ascorbate Supplement Reduces Oxidative Stress in Dyslipidemic Patients Undergoing Apheresis

Objective—The effect of ascorbate treatment on apheresis-induced oxidative stress in uremic and dyslipidemic patients was evaluated. Methods and Results—We developed a chemiluminescence-emission spectrum and high-performance liquid chromatography analysis to assess the effect of ascorbate supplement on plasma reactive oxygen species (ROS) scavenging activity and oxidized lipid/protein production in hyperlipidemic and uremic patients undergoing apheresis. Apheresis was efficient in reduction of atherogenic lipoproteins, complement, fibrinogen, soluble intercellular adhesion molecule-1, and oxidative parameters including phosphatidylcholine hydroperoxide (PCOOH), malonaldehyde, methylguanidine, and diotyrosine. Apheresis itself, however, activated leukocytes to increase ROS activity and reduced the plasma ROS scavenging activity. Ascorbate administration selectively diminished apheresis-enhanced H2O2 and inflammatory mediators such as tumor necrosis factor alpha (TNF-&agr;) and monocyte chemoattractant protein-1. Chronically dyslipidemic and uremic patients undergoing biweekly apheresis plus ascorbate treatment had lower levels of C-reactive protein and PCOOH than did those without ascorbate treatment during a 6-month follow-up study period. Conclusions—We demonstrate that apheresis with ascorbate treatment provides a therapeutic potential in reducing atherosclerotic risk via inhibition of H2O2-induced oxidative stress in patients with uremia or dyslipidemia.
Execution of a dual-object (pushing) action with semantic event chains

Execution of a manipulation after learning from demonstration many times requires intricate planning and control systems or some form of manual guidance for a robot. Here we present a framework for manipulation execution based on the so called “Semantic Event Chain” which is an abstract description of relations between the objects in the scene. It captures the change of those relations during a manipulation and thereby provides the decisive temporal anchor points by which a manipulation is critically defined. Using semantic event chains a model of a manipulation can be learned. We will show that it is possible to add the required control parameters (the spatial anchor points) to this model, which can then be executed by a robot in a fully autonomous way. The process of learning and execution of semantic event chains is explained using a box pushing example.
Role of 99mTc-ubiquicidin 29–41 scintigraphy to monitor antibiotic therapy in patients with orthopedic infection: a preliminary study

IntroductionUbiquicidin (UBI) 29–41 is a cationic synthetic antimicrobial peptide fragment that binds preferentially with anionic microbial cell membranes at the site of infection. This study evaluated the potential ability of 99mTc-UBI 29–41 to assess response to antibiotic therapy in orthopedic infection. MethodsA total of 12 patients, 10 men and two women (mean age, 41.6 years; range, 23–75 years), with suspected orthopedic infection (bone, soft tissue, or prosthesis) and positive 99mTc-UBI scan for infection were included in the study. One day after the 99mTc-UBI scan, a bone scan was performed as well. After this evaluation, eight of the nine treated cases responded to the treatment. Then, one nonresponder patient and two nontreated patients of three cases underwent antibiotic therapy and were evaluated again 10–14 days later. After this, one of the two patients not treated the first time responded to therapy and two patients did not. Moreover, one patient refused to undergo therapy both the first and second time. Thus, 11 treated cases were analyzed in this study and divided in two groups: (a) nine treated responders and (b) two treated nonresponders. In all patients, erythrocyte sedimentation rate and C-reactive protein were measured and also wound cultures were assessed. ResultsQuantitative analysis of erythrocyte sedimentation rate, C-reactive protein, and bone scan before and after the 10–14-day interval showed no significant change in either group, but a quantitative 99mTc-UBI scan at 30, 60, and 120 min after tracer injection indicated significant reduction in radiotracer uptake after the 10–14-day interval compared with the 99mTc-UBI scan before this interval in the responder group, and no significant change in the nonresponder group. ConclusionThe 99mTc-UBI scan can determine response to antibiotic therapy in orthopedic infection in humans.
Fast mapping from high resolution satellite images: a sustainable approach to provide maps for developing countries

Imagery coming from high resolution sensors seems to become in the near future a tools to derive maps, comprehending large scales as well. At the current state-of-the-art, this dream is still infeasible: the main reason is the unavailability of stereo-pairs (barring few exceptions). Results of different researches on this topic has stated the usefulness of this kind of data to yield cartography in those countries where production based on traditional methods cannot be really afforded. This impossibility is due to the high skilfulness of operators involved in the process, to the expensive hardware required (stereo-plotters or DPW), to the availability of a company which may provide aerial photos over the interested area. On the contrary, the use of satellite imagery is simpler: data can be purchased via Internet, choosing between different kinds of sensors and resolutions, processing can be completely performed by commercial SWs, control points can be measured by GPS, operations are simple and can be easily standardized. Furthermore, the technology transfer process from researchers to operators is sustainable. Obviously the cartographic product that might be obtained in this way is different with respect to a numerical 3D map derived from aerial photogrammetry. The third dimension of object cannot be computed, due to the unavalability of stereo-pairs, and the pixel size does not allow to derive maps larger than scales up to 1:10,000-1:5,000. Due to difference from the traditional cartography, either in the production process and in the content of maps, we have termed such a product “Fast Mapping”.
Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) damages the nigrostriatal dopaminergic pathway as seen in Parkinson's disease (PD), a common neurodegenerative disorder with no effective protective treatment. Consistent with a role of glial cells in PD neurodegeneration, here we show that minocycline, an approved tetracycline derivative that inhibits microglial activation independently of its antimicrobial properties, mitigates both the demise of nigrostriatal dopaminergic neurons and the formation of nitrotyrosine produced by MPTP. In addition, we show that minocycline not only prevents MPTP-induced activation of microglia but also the formation of mature interleukin-1β and the activation of NADPH–oxidase and inducible nitric oxide synthase (iNOS), three key microglial-derived cytotoxic mediators. Previously, we demonstrated that ablation of iNOS attenuates MPTP-induced neurotoxicity. Now, we demonstrate that iNOS is not the only microglial-related culprit implicated in MPTP-induced toxicity because mutant iNOS-deficient mice treated with minocycline are more resistant to this neurotoxin than iNOS-deficient mice not treated with minocycline. This study demonstrates that microglial-related inflammatory events play a significant role in the MPTP neurotoxic process and suggests that minocycline may be a valuable neuroprotective agent for the treatment of PD.
Involvement of P2Y receptors in the differentiation of haematopoietic cells

The effects of extracellular nucleotides are mediated by multiple P2X ionotropic receptors and G protein‐coupled P2Y receptors. These receptors are ubiquitous, but few physiological roles have been firmly identified. In this review article, we present a survey of the functional expression of P2Y receptors in the different haematopoietic lineages by analyzing the selectivity of these cells for the various adenine and uracil nucleotides as well as the second messenger signaling pathways involved. The pharmacological profiles of metabotropic nucleotide receptors are different among myeloid, megakaryoid, erythroid, and lymphoid cells and change during differentiation. A role of P2Y receptors in the differentiation and maturation of blood cells has been proposed: In particular the P2Y11receptor seems to be involved in the granulocytic differentiation of promyelocytes and in the maturation of monocyte‐derived dendritic cells. It is suggested that the role of P2Y receptors in the maturation of blood cells may be more important than believed so far.
Aberrant Cerebral Blood Flow in Response to Hunger and Satiety in Women Remitted from Anorexia Nervosa

The etiology of pathological eating in anorexia nervosa (AN) remains poorly understood. Cerebral blood flow (CBF) is an indirect marker of neuronal function. In healthy adults, fasting increases CBF, reflecting increased delivery of oxygen and glucose to support brain metabolism. This study investigated whether women remitted from restricting-type AN (RAN) have altered CBF in response to hunger that may indicate homeostatic dysregulation contributing to their ability to restrict food. We compared resting CBF measured with pulsed arterial spin labeling in 21 RAN and 16 healthy comparison women (CW) when hungry (after a 16-h fast) and after a meal. Only remitted subjects were examined to avoid the confounding effects of malnutrition on brain function. Compared to CW, RAN demonstrated a reduced difference in the Hungry − Fed CBF contrast in the right ventral striatum, right subgenual anterior cingulate cortex (pcorr < 0.05) and left posterior insula (punc < 0.05); RAN had decreased CBF when hungry versus fed, whereas CW had increased CBF when hungry versus fed. Moreover, decreased CBF when hungry in the left insula was associated with greater hunger ratings on the fasted day for RAN. This represents the first study to show that women remitted from AN have aberrant resting neurovascular function in homeostatic neural circuitry in response to hunger. Regions involved in homeostatic regulation showed group differences in the Hungry − Fed contrast, suggesting altered cellular energy metabolism in this circuitry that may reduce motivation to eat.
Key Role for Clumping Factor B in Staphylococcus aureus Nasal Colonization of Humans

Background Staphylococcus aureus permanently colonizes the vestibulum nasi of one-fifth of the human population, which is a risk factor for autoinfection. The precise mechanisms whereby S. aureus colonizes the nose are still unknown. The staphylococcal cell-wall protein clumping factor B (ClfB) promotes adhesion to squamous epithelial cells in vitro and might be a physiologically relevant colonization factor. Methods and Findings We define the role of the staphylococcal cytokeratin-binding protein ClfB in the colonization process by artificial inoculation of human volunteers with a wild-type strain and its single locus ClfB knock-out mutant. The wild-type strain adhered to immobilized recombinant human cytokeratin 10 (CK10) in a dose-dependent manner, whereas the ClfB− mutant did not. The wild-type strain, when grown to the stationary phase in a poor growth medium, adhered better to CK10, than when the same strain was grown in a nutrient-rich environment. Nasal cultures show that the mutant strain is eliminated from the nares significantly faster than the wild-type strain, with a median of 3 ± 1 d versus 7 ± 4 d (p = 0.006). Furthermore, the wild-type strain was still present in the nares of 3/16 volunteers at the end of follow-up, and the mutant strain was not. Conclusions The human colonization model, in combination with in vitro data, shows that the ClfB protein is a major determinant of nasal-persistent S. aureus carriage and is a candidate target molecule for decolonization strategies.
Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein

The adenovirus early region 1A (E1A) oncoprotein mediates cell transformation by deregulating host cellular processes and activating viral gene expression by recruitment of cellular proteins that include cyclic-AMP response element binding (CREB) binding protein (CBP)/p300 and the retinoblastoma protein (pRb). While E1A is capable of independent interaction with CBP/p300 or pRb, simultaneous binding of both proteins is required for maximal biological activity. To obtain insights into the mechanism by which E1A hijacks the cellular transcription machinery by competing with essential transcription factors for binding to CBP/p300, we have determined the structure of the complex between the transcriptional adaptor zinc finger-2 (TAZ2) domain of CBP and the conserved region-1 (CR1) domain of E1A. The E1A CR1 domain is unstructured in the free state and upon binding folds into a local helical structure mediated by an extensive network of intermolecular hydrophobic contacts. By NMR titrations, we show that E1A efficiently competes with the N-terminal transactivation domain of p53 for binding to TAZ2 and that pRb interacts with E1A at 2 independent sites located in CR1 and CR2. We show that pRb and the CBP TAZ2 domain can bind simultaneously to the CR1 site of E1A to form a ternary complex and propose a structural model for the pRb:E1A:CBP complex on the basis of published x-ray data for homologous binary complexes. These observations reveal the molecular basis by which E1A inhibits p53-mediated transcriptional activation and provide a rationale for the efficiency of cellular transformation by the adenoviral E1A oncoprotein.
Gravitational Wave Spectrum Induced by Primordial Scalar Perturbations

We derive the complete spectrum of gravitational waves induced by primordial scalar perturbations ranging over all observable wavelengths. This scalar-induced contribution can be computed directly from the observed scalar perturbations and general relativity and is, in this sense, independent of the cosmological model for generating the perturbations. The spectrum is scale invariant on small scales, but has an interesting scale dependence on large and intermediate scales, where scalar-induced gravitational waves do not redshift and are hence enhanced relative to the background density of the Universe. This contribution to the tensor spectrum is significantly different in form from the direct model-dependent primordial tensor spectrum and, although small in magnitude, it dominates the primordial signal for some cosmological models. We confirm our analytical results by direct numerical integration of the equations of motion.
Algorithms for optimal scheduling and management of hidden Markov model sensors

The author considers a hidden Markov model (HMM) where a single Markov chain is observed by a number of noisy sensors. Due to computational or communication constraints, at each time instant, one can select only one of the noisy sensors. The sensor scheduling problem involves designing algorithms for choosing dynamically at each time instant which sensor to select to provide the next measurement. Each measurement has an associated measurement cost. The problem is to select an optimal measurement scheduling policy to minimize a cost function of estimation errors and measurement costs. The optimal measurement policy is solved via stochastic dynamic programming. Sensor management issues and suboptimal scheduling algorithms are also presented. A numerical example that deals with the aircraft identification problem is presented.
On the Expressivity of Symmetry in Event Structures

This paper establishes a bridge between presheaf models for concurrency and the more operationally-informative world of event structures. It concentrates on a particular presheaf category, consisting of presheaves over finite partial orders of events; such presheaves form a model of nondeterministic processes in which the computation paths have the shape of partial orders. It is shown how with the introduction of symmetry event structures represent all presheaves over finite partial orders. This is in contrast with plain event structures which only represent certain separated presheaves. Specifically a coreflection from the category of presheaves to the category of event structures with symmetry is exhibited. It is shown how the coreflection can be cut down to an equivalence between the presheaf category and the subcategory of graded event structures with symmetry. Event structures with strong symmetries are shown to represent precisely all the separated presheaves. The broader context and specific applications to the unfolding of higher-dimensional automata and Petri nets, and weak bisimulation on event structures are sketched.
A Point Process Describing the Component Sizes in the Critical Window of the Random Graph Evolution

We study a point process describing the asymptotic behaviour of sizes of the largest components of the random graph G(n, p) in the critical window, that is, for p = n−1 + λn−4/3, where λ is a fixed real number. In particular, we show that this point process has a surprising rigidity. Fluctuations in the large values will be balanced by opposite fluctuations in the small values such that the sum of the values larger than a small ϵ (a scaled version of the number of vertices in components of size greater than εn2/3) is almost constant.
Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects.

OBJECTIVE 1) To evaluate the effect of a single oral dose of hexyl-insulin monoconjugate 2 (HIM2) on the rate of whole-body glucose disposal (Rd) and endogenous glucose production (EGP) in healthy nondiabetic subjects, 2) to examine the reproducibility of HIM2 on glucose metabolism, and 3) to compare the results obtained with HIM2 with those using a bioequivalent dose of subcutaneous lispro insulin. RESEARCH DESIGN AND METHODS Six healthy subjects ([means +/- SE] aged 31 +/- 5 years and BMI 23.1 +/- 3.9 kg/m2) participated in four studies performed in random order on separate days. Subjects ingested a single dose of HIM2 (0.125, 0.5, and 0.75 mg/kg) or received subcutaneous lispro insulin (0.1 units/kg). Studies were performed with [3-3H]glucose, and plasma glucose concentration was maintained at basal levels for 4 h with the euglycemic clamp technique. After 6 weeks, subjects participated in two repeat studies to examine the reproducibility of HIM2 (0.5 mg/kg) and lispro insulin (0.1 units/kg). RESULTS Fasting plasma insulin (7 muU/ml) increased to a maximum of 102, 321, and 561 muU/ml at 60 min after all three HIM2 doses (0.125, 0.5, and 0.75 mg/kg, respectively). A dose-related decrease in basal EGP was observed as the HIM2 dosage was increased from 0 to 0.125 to 0.5 mg/kg (P <0.05 vs. each preceding dose). Suppression of EGP was similar with the 0.5- and 0.75-mg/kg HIM2 doses. A dose-related stimulation of basal Rd was observed as the HIM2 dosage was increased from 0 to 0.125 to 0.5 (P <0.05 vs. each preceding dose) to 0.75 mg/kg (P <0.10 vs. preceding dose). Rd (0-240 min) was increased by 0.5 mg/kg oral HIM2 to a value similar to 0.1 units/kg lispro insulin. The 0.125-mg/kg HIM2 dose reduced EGP (0-240 min) to a value that was similar to 0.1 units/kg lispro insulin. The variability in the effect of HIM2 and lispro on Rd (25 +/- 7 vs. 27 +/- 1%, respectively) and on suppression of EGP (19 +/- 1 vs. 19 +/- 0.7%, respectively) was similar. CONCLUSIONS Oral HIM2 suppresses EGP and increases tissue Rd in a dose-dependent manner. The effects of HIM2 on EGP and Rd persisted at 240 min, even though plasma insulin concentration had returned to basal levels. Oral HIM2 may provide an effective and reproducible means of controlling postprandial plasma glucose excursions in diabetic patients.