Miracle-dz/UniFAR-FTUs huggingface dataset:
Interleukin-17: A Promoter in Colorectal Cancer Progression

It is widely accepted that chronic inflammation plays an active role in cancer. Inflammatory immunocytes and related cytokines in the tumor microenvironment are supposed to be a “double-edged sword” in colorectal cancer (CRC) initiation and progression. Interleukin-17 (IL-17), a pleiotropic proinflammatory cytokine, can promote cancer-elicited inflammation and prevent cancer cells from immune surveillance. Despite controversy, IL-17 is generally considered to be a promoter in CRC progression. In this review, we devote to summarize the current progress regarding the role of IL-17 in tumor initiation and progression, as well as the prognostic value in CRC.
Engineering graphene by oxidation: a first-principles study

Graphene epoxide, with oxygen atoms lining up on pristine graphene sheets, is investigated theoretically here using first-principles calculations. Two distinct phases—metastable clamped and stable unzipped structures—are observed consistent with experimental observations. In the clamped structure, oxygen atoms form a regular lattice on the graphene sheet. In the unzipped phase, an epoxy group breaks the lower sp2 bond and modifies the mechanical and electronic properties of graphene remarkably. The foldable epoxy ring structure reduces its Young’s modulus by 42.4%, while leaving the tensile strength almost unchanged. The perturbation of epoxidation on the band structures depends on the density and symmetry of oxidation. These results pave the way for oxidation-based engineering of graphene-related materials.
Durable Consumption and Asset Management with Transaction and Observation Costs

The empirical evidence on rational inattention lags far behind the theoretical developments: micro evidence on the most immediate consequence of observation costs - the infrequent observation of state variables - is not available in standard datasets. We contribute to filling the gap with two novel household surveys that record the frequency with which investors observe the value of their financial investments, as well as the frequency with which they trade in financial assets and durable goods. We use these data to test some predictions of existing models and show that to match the patterns in the data we need to modify these models by shifting the focus from non-durable to durable consumption. The model we develop features both observation and transaction costs and implies a mixture of time-dependent and state-dependent rules, where the importance of each rule depends on the ratio of the observation to the transaction cost. Numerical simulations show that the model can produce frequency of portfolio observations and asset trading comparable to that of the median investor (about 4 and 0.4 per year, respectively) with small observation costs (about 1 basis point of financial wealth) and larger transaction costs (about 30 basis points of financial wealth). In spite of its small size the observation cost gives rise to infrequent information gathering (between monthly and quarterly). A quantitative assessment of the relevance of the observation costs shows that the behavior of the investors is essentially unchanged compared to the one produced by a model with transaction but no observation cost. We test a novel prediction of the model on the relationship between assets trades and durable-goods trades and find that it is aligned with the data.
NONCOMMUTATIVE DIFFERENTIAL CALCULUS

This is a note from B. Tsygan’s lecture series which was part of masterclass “Algebraic structure of Hochschild complexes” at the University of Copenhagen in October 2015. From the course description: I will review the current state of noncommutative differential calculus. The term stands for the theory that generalizes classical algebraic structures arising in differential calculus on manifolds to make them valid for any associative algebra (or, more generally, any differential graded category) instead of the algebra of functions on a manifold. The role of differential forms and multi-vector fields in this new theory is played by the Hochschild complexes of our algebra. The generalized algebraic structures from classical calculus are provided by the action of various operads on these complexes. I will summarize the current state of the subject as developed in the works of Kontsevich and Soibelman, Tamarkin, Willwacher, and other authors, as well as my own works in collaboration with Dolgushev, Nest, and Tamarkin. 1. Hochschild and Cyclic Homologies 1.1. Basic definitions. Throughout the course k denotes a field of characteristic 0. Let A be a unital associative algebra over k. We put Ā := A/k · 1 and Cn(A) := Cn(A,A) = A⊗ Ā⊗n for each integer n ≥ 0. Define b : Cn(A)→ Cn−1(A) and B : Cn(A)→ Cn+1(A) by b(a0 ⊗ . . .⊗ an) = n−1 ∑ j=0 a0 ⊗ . ⊗ ajaj+1 ⊗ . an + (−1)ana0 ⊗ a1 . ⊗ an−1, B(a0 ⊗ . . .⊗ an) = n ∑ j=0 (−1)1⊗ aj ⊗ . ⊗ an ⊗ a0 ⊗ . ⊗ aj−1. Note that we have bB +Bb = b = B = 0. Definition 1.1. Let u be a formal variable of degree |u| = −2. We consider the following complexes: (reduced) Hochschild complex : (C•(A), b), negative cyclic complex : CC• (A) := (C•(A)JuK, b+ uB), periodic cyclic complex : CC • (A) := (C•(A) ((u)) , b+ uB), cyclic complex : CC•(A) := (C•(A) ((u)) /uC•(A)JuK, b+ uB). Their homology groups are respectively denoted by HH•(A), HC − • (A), HC per • (A), and HC•(A). Here, C•(A)JuK is the space of formal power series in the formal variable u with coefficients in C•(A). More formally, it is just the infinite direct product C•(A) ∞, where (x0, x1, · · · ) for xn ∈ C•(A) corresponds to the series ∑∞ n=0 xnu . Similarly, C• ((u)) = C•JuK[u] denotes the space of Laurent power series ∑∞ n=−∞ xnu n with xn = 0 for n 0. The diagram of Figure 1 clears up the above definitions. Here, the Hochschild complex is given by the column marked (∗), the negative cyclic complex is obtained by considering this column and the ones to the right of it, the cyclic complex is obtained by removing the columns to the right of (∗), and the total double complex gives us the periodic cyclic complex. Remark 1.2. It is sometimes convenient to work with the unreduced Hochschild complex C • (A) = A⊗•+1 with the Hochschild differential b given by the same formula as above. Note that the obvious surjection C • (A) → C•(A) admits a homotopy inverse coming from insertion of unit, and the operator B lifts to a differential on C • (A). 1
Asset Purchase Policy at the Effective Lower Bound for Interest Rates

This paper studies optimal policy in a stylised New Keynesian model that is extended to incorporate imperfect substitutability between short-term and long-term bonds. This simple modification provides a channel through which asset purchases by the policy maker can affect aggregate demand. Because assets are imperfect substitutes, central bank asset purchases that alter the relative supplies of assets can influence their prices. In the model, aggregate demand depends on the prices (or interest rates) of both long-term and short-term bonds. To the extent that central bank asset purchases reduce long-term interest rates (over and above the effect of expected future short rates), aggregate demand can be stimulated, leading to higher inflation through a standard New Keynesian Phillips Curve. However, the imperfect substitutability between bonds that gives asset purchases their traction also reduces the potency of conventional monetary policy because reductions in the short-term nominal interest rate reduce the relative supply of short-term bonds, increasing the premium on long-term bonds. Nevertheless, a policy in which the policymaker uses asset purchases as an additional policy instrument can improve outcomes in the face of a negative demand shock that drives the short-term policy rate to its lower bound. This is true even if asset purchases policies are also subject to (both upper and lower) bounds.
Happiness from the perspective of mother and children: Indonesian setting

ABSTRACT This study aims to evaluate whether mothers and their children have the same perspective on the children’s happiness. It enriched studies gap concerning agreement on perspective about young children happiness. Some studies showed agreement, the others showed disagreement. In total 777 children and 367 mothers were involved in this study. This study used face scale test for children to address their happiness. This study required mothers to recognize face scales and give ratings as to what the level of their children’s happiness was. The Spearman rho analysis was revealed that Indonesian mothers and children have discrepancies on happiness (r = 0.091; p = .080). In view of gender difference, agreement was found between mothers and sons (r = 0.195; p = .009), but not on daughters. It is needed to develop parenting program to educate mothers on how build better communication particularly with daughters.
Exploring organisational use of negative emotions on Facebook and their effect on brand perceptions

This study explores the use of negative emotions on social media by organisations, with the main purpose being to discover how consumers perceive the content. Research in the past has focused on advertising, with little attempt made to understand the response to negative emotions on social media. This study used a multi-method qualitative approach with an interpretive paradigm. First, five online observations were made from real companies on Facebook, finding what sort of reaction these type of emotions evoked. Next were sixteen 1-to-1 interviews where participants viewed mock Facebook pages, one containing posts with negative emotions and one containing solely positive posts. The findings show the consumer has complex and varied reactions to negative emotions on social media. Often, they see benefits such as the posts grabbing their attention and creating an emotional connection. But they also react negatively - not wanting to see the post on their own Facebook newsfeed. There was also a general mistrust of marketing - participants expected companies to use unethical marketing techniques. The study concludes that using negative emotions on Facebook can have some benefits, with these however being greatly outweighed by the potential to leave consumers with a negative perception of the brand.
A comprehensive compact-modeling methodology for spiral inductors in silicon-based RFICs

A new comprehensive wide-band compact-modeling methodology for on-chip spiral inductors is presented. The new modeling methodology creates an equivalent-circuit model consisting of frequency-independent circuit elements. A fast automated extraction procedure is developed for determining the circuit element values from two-port S-parameter measurement data. The methodology is extremely flexible in allowing for accurate modeling of general classes of spiral inductors on high- or low-resistivity substrate and for large spirals exhibiting distributed trends. The new modeling methodology is applied to general classes of spirals with various sizes and substrate parameters. The extracted models show excellent agreement with the measured data sets over the frequency range of 0.1-10 GHz.
Relationship with God and the Word: Faith among American Evangelical Christian families

Abstract A little more than 40% of Americans self-identify with the Evangelical Christian faith. American Evangelical Christians generally report that the primary convictions of their faith are a strong belief in the Bible and deep commitment to and personal relationship with Jesus Christ. We explore how these specific faith convictions and practices of Evangelical Christians influence their family life and family interactions. The article is based on in-depth qualitative interviews with 23 Evangelical Christian families (46 parents, 10 youth). Themes related to the domain of marital strengths included: (1) enhancing marital unity, (2) resolving marital conflict, and (3) giving and receiving forgiveness in marriage. The three central themes related to parenting include: (1) enhancing parent–child unity, (2) resolving parent–child conflict, and (3) giving and receiving forgiveness.
Probable member stars of the gravitational theory-testing globular clusters AM 1, Pal 3 and Pal 14

Some of the Galactic outer halo globular clusters are excellent tools to probe gravitational theories in the regime of weak accelerations. The measurement of the line-of-sight velocity dispersion among stars in these clusters will differentiate between the validity of Newtonian dynamics (low velocity dispersion) and the possiblity of modified Newtonian dynamics (MOND) or dark matter dominated globular clusters (high velocity dispersion). In this paper, the properties of probable member stars of the three best-case gravitational theory-testing clusters AM 1, Pal 3 and Pal 14 are presented. The member selection is based on VLT photometry in Johnson $\it BV$. The positions of the stars were determined with an accuracy of the order of ≤ $0\farcs2$, allowing their direct use for follow-up spectroscopy. The distance, reddening, age and metallicities of the clusters were estimated from isochrone fitting. Furthermore, improved structural parameters, like central coordinates, ellipticity, half-light radius, King model core and tidal radius, are presented.
CapEst : Estimating wireless link capacity in multi-hop networks

Estimating link capacity in a wireless network is a complex task because the available capacity at a link is a function ofnot only the current arrival rate at that link, but also of the arr ival rate at links which interfere with that link as well as of the nature of interference between these links. Models which accurately c haracterize this dependence are either too computationally complex to b e useful or lack accuracy. Further, they have a high implementation ove rhead and make restrictive assumptions, which makes them inapplicab le to real networks. In this paper, we propose CapEst, a general, simple yet accur ate, measurement-based approach to estimating link capacity ina wireless network. To be computationally light, CapEst allows inaccuracy in estimation; however, using measurements, it can correct th is inaccuracy in an iterative fashion and converge to the correct estimate. Ou r evaluation shows that CapEst always converged to within5% of the correct value in less than18 iterations. CapEst is model-independent, hence, is applic able to any MAC/PHY layer and works with auto-rate adaptation. Moreover, it has a low implementation overhead, can be used with any app lication which requires an estimate of residual capacity on a wireles s link and can be implemented completely at the network layer without any support from the underlying chipset.
Moment Stability Properties of State-dependent Queueing Networks

We consider a class of queueing networks with state-dependent arrival and service rates. Under the uniform (in state) stability condition, we establish several moment stability properties of the queue length process: (i) the unique invariant measure of the queue length process admits a nite moment generating function in a neighborhood of zero; (ii) the expected value of unbounded (and possibly exponentially growing) functionals of the state process converges to the expectation under the invariant measure at an exponential rate; (iii) uniform (in time and initial condition in a compact set) estimates on exponential moments of the process; (iv) growth estimates of polynomial moments of the process as a function of the initial conditions. We note that our approach provides elementary proofs of these stability properties without resorting to the convergence of the scaled process to a stable uid limit model.
The Extended algebra of observables for Dirac fields and the trace anomaly of their stress-energy tensor

We discuss from scratch the classical structure of Dirac spinors on an arbitrary globally hyperbolic, Lorentzian spacetime, their formulation as a locally covariant quantum field theory, and the associated notion of a Hadamard state. Eventually, we develop the notion of Wick polynomials for spinor fields, and we employ the latter to construct a covariantly conserved stress-energy tensor suited for back-reaction computations. We shall explicitly calculate its trace anomaly in particular.
School Engagement and the Role of Peer Victimization, Depressive Symptoms, and Rumination

The purpose of the current study was to explore the association between peer victimization and school engagement and the indirect effects of rumination and depressive symptoms in this association. Data on middle school students’ victimization experiences, school engagement, rumination, and depressive symptoms were collected from 887 sixth- through eighth-grade students utilizing self-report measures. Results indicated for both boys and girls a significant negative association between peer victimization and school engagement. Furthermore, a significant indirect effect of rumination and depression symptoms was evident for both boys and girls, but these effects were more robust for girls. Furthermore, the direct relation between depressive symptoms and school engagement was stronger for girls. Implications of these findings are discussed.
The Elongation Complex Components BRD4 and MLLT3/AF9 Are Transcriptional Coactivators of Nuclear Retinoid Receptors

Nuclear all-trans retinoic acid receptors (RARs) initiate early transcriptional events which engage pluripotent cells to differentiate into specific lineages. RAR-controlled transactivation depends mostly on agonist-induced structural transitions in RAR C-terminus (AF-2), thus bridging coactivators or corepressors to chromatin, hence controlling preinitiation complex assembly. However, the contribution of other domains of RAR to its overall transcriptional activity remains poorly defined. A proteomic characterization of nuclear proteins interacting with RAR regions distinct from the AF-2 revealed unsuspected functional properties of the RAR N-terminus. Indeed, mass spectrometry fingerprinting identified the Bromodomain-containing protein 4 (BRD4) and ALL1-fused gene from chromosome 9 (AF9/MLLT3), known to associate with and regulates the activity of Positive Transcription Elongation Factor b (P-TEFb), as novel RAR coactivators. In addition to promoter sequences, RAR binds to genomic, transcribed regions of retinoid-regulated genes, in association with RNA polymerase II and as a function of P-TEFb activity. Knockdown of either AF9 or BRD4 expression affected differentially the neural differentiation of stem cell-like P19 cells. Clusters of retinoid-regulated genes were selectively dependent on BRD4 and/or AF9 expression, which correlated with RAR association to transcribed regions. Thus RAR establishes physical and functional links with components of the elongation complex, enabling the rapid retinoid-induced induction of genes required for neuronal differentiation. Our data thereby extends the previously known RAR interactome from classical transcriptional modulators to components of the elongation machinery, and unravel a functional role of RAR in transcriptional elongation.
Planning Collision-Free Trajectories for Reversing Multiply-Articulated Vehicles

A global path-planning strategy is proposed which defines the geometric path of the rear trailer axle of a multiply-articulated vehicle traveling in reverse. This is intended for use in conjunction with a path-tracking reversing controller. A general multiple-trailer vehicle model is derived and used to model a “B-double” heavy vehicle combination, which has two trailers. The curvature properties of a path for the rear trailer axle are investigated, and an empirical relationship is defined between the curvature and the length over which the curvature changes. This is used to generate a library of feasible path segments, and the vehicle model is used to calculate swept paths. A Dijkstra grid search algorithm is then used to connect the path segments together to generate a collision-free composite path. An example path generation is presented for the B-double.
Acupuncture Attenuates Anxiety-Like Behavior by Normalizing Amygdaloid Catecholamines during Ethanol Withdrawal in Rats

Previously, we demonstrated acupuncture at acupoint HT7 (Shen-Men) attenuated ethanol withdrawal syndrome by normalizing the dopamine release in nucleus accumbens shell. In the present study, we investigated the effect of acupuncture on anxiety-like behavior in rats and its relevant mechanism by studying neuro-endocrine parameters during ethanol withdrawal. Rats were treated with 3 g kg−1day−1 of ethanol (20%, w/v) or saline by intraperitoneal injections for 28 days. The rats undergoing ethanol withdrawal exhibited anxiety-like behavior 72 h after the last dose of ethanol characterized by the decrease of time spent in the open arms of the elevated plus maze compared with the saline-treated rats (P < .05). Radioimmunoassay exhibited there were notably increased concentrations of plasma corticosterone in ethanol-withdrawn rats compared with saline-treated rats (P < .05). Additionally, high performance liquid chromatography analysis also showed the levels of norepinephrine and 3-methoxy-4-hydroxy-phenylglycol were markedly increased while the levels of dopamine and 3,4-dihydroxyphenylacetic acid were significantly decreased in the central nucleus of the amygdala of ethanol-withdrawn rats compared with saline-treated rats (P < .01). Acupuncture groups were treated with acupuncture at acupoint HT7 or PC6 (Nei-Guan). Acupuncture at HT7 but not PC6 greatly attenuated the anxiety-like behavior during ethanol withdrawal as evidenced by significant increases in the percentage of time spent in open arms (P < .05). In the meantime, acupuncture at HT7 also markedly inhibited the alterations of neuro-endocrine parameters induced by ethanol withdrawal (P < .05). These results suggest that acupuncture may attenuate anxiety-like behavior during ethanol withdrawal through regulation of neuro-endocrine system.
The Company Approach to Software Engineering Project Courses

Teaching larger software engineering project courses at the end of a computing curriculum is a way for students to learn some aspects of real-world jobs in industry. Such courses, often referred to as capstone courses, are effective for learning how to apply the skills they have acquired in, for example, design, test, and configuration management. However, these courses are typically performed in small teams, giving only a limited realistic perspective of problems faced when working in real companies. This paper describes an alternative approach to classic capstone projects, with the aim of being more realistic from an organizational, process, and communication perspective. This methodology, called the company approach, is described by intended learning outcomes, teaching/learning activities, and assessment tasks. The approach is implemented and evaluated in a larger Master's student course.