Miracle-dz/UniFAR-FTUs huggingface dataset:
Brain magnetic resonance imaging in multiple-system atrophy and Parkinson disease: a diagnostic algorithm.

BACKGROUND Brain magnetic resonance (MR) imaging offers the potential for objective criteria in the differential diagnosis of multiple system atrophy with predominant parkinsonism (MSA-P) and Parkinson disease (PD), since it frequently shows characteristic abnormalities in patients with MSA-P and is believed to be normal in patients with PD. OBJECTIVE To determine concordance between clinical and MR imaging-based diagnoses of MSA-P and PD. DESIGN Two neuroradiologists identified and rated striatal and infratentorial abnormalities in 39 brain MR images and assigned a diagnosis of PD, MSA-P, or MSA with additional marked cerebellar ataxia (MSA-C). SETTING Academic medical center. PATIENTS Thirty-nine patients with parkinsonism, including 21 with a clinical diagnosis of PD, 14 with MSA-P, and 4 with MSA-C. RESULTS All patients with MSA and 14 (67%) of 21 patients with PD had some abnormality on brain MR imaging. Brainstem atrophy was seen in patients with MSA-P and MSA-C. Putaminal atrophy was seen only in MSA-P. Putaminal hypointensity and lateral slitlike hyperintensity were seen in both PD and MSA-P but were always mild in PD. Cerebellar abnormalities, seen in all patients with MSA-C and 11 patients with MSA-P, were also identified in 6 patients with PD, albeit always rated as mild. Nonconcordance between clinical and radiological diagnosis occurred in 2 patients with PD, 5 with MSA-P, and 1 with MSA-C. CONCLUSION Since several features on brain MR imaging are seen only in MSA-P, a simple diagnostic algorithm may improve the MR imaging diagnosis of MSA-P and PD.
Legal Needs Arising in Mental Health Settings and Staff Capability and Support to Respond

Introduction: Legal issues are known to affect and be affected by mental health. But to what extent do legal issues surface in mental health settings and what do staff feel they need to support clients experiencing these issues? These questions were explored by a national mental health service interested in the potential for health justice partnership with local community based legal services. Methods: A survey of 999 frontline staff of a national mental health organisation. 146 staff (15%) responded from 70 service sites across Australia, including peer support workers (47%), support workers (20%), team leaders (17%) and clinicians (15%). Results: Staff identified a wide range of legal issues experienced by their clients (commonly referred to by staff as consumers), most commonly credit, debt and social security issues, housing, family law and family violence. Two-thirds (67%) of respondents indicated that they spent around 50% or more of their time ‘responding to these types of issues’. Respondents indicated that they need more support to address legal issues facing their clients, particularly more knowledge of other services, connections with professionals in other organisations and connections with community. They also felt they could benefit from additional processes, tools, and resources, and time to manage their case load. Originality: While there is an emerging field of research exploring the legal capability of citizens, this study explores what mental health service staff feel they need to support consumers experiencing legal issues that can interact with mental health.
Greenland Submarine Melt Water Observed in the Labrador and Irminger Sea

Helium and Neon distributions from 1994 to 2015 are used to identify and quantify submarine melt water (SMW) from the Greenland Ice Sheet in the Labrador and Irminger Sea. SMW fractions >0.2% (maximum 0.62 ± 0.075%) are confined in the upper 400 m of the Greenland shelf and slope and account for 12 ± 6% of the total east Greenland freshwater flux. SMW is embedded in water of different mixtures of cold and fresh Polar Water and warm and saline Atlantic Water. The resulting salinity range from that mixture exceeds the effect of SMW addition by one order of magnitude. Up to now, SMW is not detectable in the formation region of the Labrador Sea Water. Episodically, He and Ne excess anomalies are found in the deep ocean, probably introduced by the East Greenland Current spill jets.
Can Research Assessments Themselves Cause Bias in Behaviour Change Trials? A Systematic Review of Evidence from Solomon 4-Group Studies

Background The possible effects of research assessments on participant behaviour have attracted research interest, especially in studies with behavioural interventions and/or outcomes. Assessments may introduce bias in randomised controlled trials by altering receptivity to intervention in experimental groups and differentially impacting on the behaviour of control groups. In a Solomon 4-group design, participants are randomly allocated to one of four arms: (1) assessed experimental group; (2) unassessed experimental group (3) assessed control group; or (4) unassessed control group. This design provides a test of the internal validity of effect sizes obtained in conventional two-group trials by controlling for the effects of baseline assessment, and assessing interactions between the intervention and baseline assessment. The aim of this systematic review is to evaluate evidence from Solomon 4-group studies with behavioural outcomes that baseline research assessments themselves can introduce bias into trials. Methodology/Principal Findings Electronic databases were searched, supplemented by citation searching. Studies were eligible if they reported appropriately analysed results in peer-reviewed journals and used Solomon 4-group designs in non-laboratory settings with behavioural outcome measures and sample sizes of 20 per group or greater. Ten studies from a range of applied areas were included. There was inconsistent evidence of main effects of assessment, sparse evidence of interactions with behavioural interventions, and a lack of convincing data in relation to the research question for this review. Conclusions/Significance There were too few high quality completed studies to infer conclusively that biases stemming from baseline research assessments do or do not exist. There is, therefore a need for new rigorous Solomon 4-group studies that are purposively designed to evaluate the potential for research assessments to cause bias in behaviour change trials.
Managing hospitals in turbulent times: do organizational changes improve hospital survival?

OBJECTIVE To examine (1) the degree to which organizational changes affected hospital survival; (2) whether core and peripheral organizational changes affected hospital survival differently; and (3) how simultaneous organizational changes affected hospital survival. DATA SOURCES AHA Hospital Surveys, the Area Resource File, and the AHA Hospital Guides, Part B: Multihospital Systems. STUDY DESIGN The study employed a longitudinal panel design. We followed changes in all community hospitals in the continental United States from 1981 through 1994. The dependent variable, hospital closure, was examined as a function of multiple changes in a hospital's core and peripheral structures as well as the hospital's organizational and environmental characteristics. Cox regression models were used to test the expectations that core changes increased closure risk while peripheral changes decreased such risk, and that simultaneous core and peripheral changes would lead to higher risk of closure. PRINCIPAL FINDINGS Results indicated more peripheral than core changes in community hospitals. Overall, findings contradicted our expectations. Change in specialty, a core change, was beneficial for hospitals, because it reduced closure risk. The two most frequent peripheral changes, downsizing and leadership change, were positively associated with closure. Simultaneous organizational changes displayed a similar pattern: multiple core changes reduced closure risk, while multiple peripheral changes increased the risk. These patterns held regardless of the level of uncertainty in hospital environments. CONCLUSIONS Organizational changes are not all beneficial for hospitals, suggesting that hospital leaders should be both cautious and selective in their efforts to turn their hospitals around.
Combined Use of Remote Sensing Data, Mineralogical Analyses, Microstructure Studies and Geographic Information System for Geological Mapping of Antiparos Island (Greece)

This study presents the combined use of field mapping, remote sensing data analysis, mineralogy, spectroscopy and GIS techniques for the geological mapping of Antiparos Island. Antiparos is part of the Cyclades Blueschist Belt located in central Aegean, where gneisses, schists and Pliocene volcanic rocks occurred. During the extended field work, a number of volcanic rock samples were collected from the southern part of Antiparos. The sampling strategy was to collect samples from the primary as well as the altered rocks in specific areas in which they were previously located from the remote sensing data processing. In this study, high resolution satellite images have been carried out in order to detect, allocate and separate the different geological formations. Furthermore, the existing geological map was georeferenced and all the tectonic lines and boundaries were digitized. All these features were implemented in a Mobile Mapper CE GPS using Arcpad GIS and checked in situ. The collected samples were analyzed in the laboratory using various techniques including XRD, Petrographic Microscopy and SEM. The qualitative mineralogical analyses were conducted by using XRD. The study was supplemented by the petrographic observations providing a detailed characterization of rock textures. In addition, SEM study and SEM-EDS analyses of the samples were emphasized on the genetic relations of the minerals. The laboratory results revealed that specific corrections should be made in the previous geological map of Antiparos concerning the volcanic rocks, especially at the southern part of the island. A significant conclusion is that the rock described as volcanic in the previous map proved to be a fossiliferous limestone which includes micritic matrix of calcite with an insignificant amount of fossils. All the analogical and digital data and the results of the petrographic analysis were imported in a geodatabase specially designed for geological data. After the necessary topological control and corrections, the data were unified and processed in order to create the final layout at 1/25.000 scale.
Automated Grading of Angelica sinensis Using Computer Vision and Machine Learning Techniques

Angelica sinensis (Oliv.) Diels, a member of the Umbelliferae family, is commonly known as Danggui (Angelica sinensis, AS). AS has the functions of blood tonic, menstrual pain relief, and laxatives. Accurate classification of AS grades is crucial for efficient market management and consumer health. The commonly used method to classify AS grades depends on the evaluator’s observation and experience. However, this method has issues such as unquantifiable parameters and inconsistent identification results among different evaluators, resulting in a relatively chaotic classification of AS in the market. To address these issues, this study introduced a computer vision-based approach to intelligently grade AS. Images of AS at five grades were acquired, denoised, and segmented, followed by extraction of shape, color, and texture features. Thirteen feature parameters were selected based on difference and correlation analysis, including tail area, whole body area, head diameter, G average, B average, R variances, G variances, B variances, R skewness, G skewness, B skewness, S average, and V average, which exhibited significant differences and correlated with grades. These parameters were then used to train and test both the traditional back propagation neural network (BPNN) and the BPNN model improved with a growing optimizer (GOBPNN). Results showed that the GOBPNN model achieved significantly higher average testing precision, recall, F-score, and accuracy (97.1%, 95.9%, 96.5%, and 95.0%, respectively) compared to the BPNN model. The method combining machine vision technology with GOBPNN enabled efficient, objective, rapid, non-destructive, and cost effective AS grading.
Three to Tango: MUC1 as a Ligand for Both E-Selectin and ICAM-1 in the Breast Cancer Metastatic Cascade

Cancer cell tethering and rolling on the vascular wall is facilitated by various selectin: glycoprotein interactions which lead to eventual extravasation and metastases. The aberrantly underglycosylated mucin MUC1 has been shown to both abundantly express selectin binding moieties (sialyl Lewis x and a) and to consistently expose its core epitope. Flow cytometry was used to determine MUC1 expression on ZR-75-1 and MCF7 cells, while immunofluorescence microscopy was used to confirm the aberrant form of MUC1 and MUC1:ICAM-1 interactions. Each cell line was then perfused through combined E-selectin and ICAM-1 coated microtubes, as a model of the microvascular endothelium. ZR-75-1 and MCF7 were found to express abundant and low levels of underglycosylated MUC1, respectively. The rolling/adhesion profiles showed that ZR-75-1 cells, when compared to MCF7 cells, interact with E-selectin more efficiently resulting in sufficiently slow rolling velocities to form MUC1:ICAM-1 interactions thereby facilitating firm adhesion. The purpose and novelty of this work is the demonstration of the synergistic adhesion capabilities of MUC1 in the metastatic adhesion cascade, where the observed differential adhesion is consistent with the relative metastatic potential of the ZR-75-1 (highly metastatic) and MCF7 (weakly metastatic) cell lines.
Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells

Eukaryotic cells contain hundreds of metalloproteins that are supported by intracellular systems coordinating the uptake and distribution of metal cofactors. Iron cofactors include heme, iron–sulfur clusters, and simple iron ions. Poly(rC)-binding proteins are multifunctional adaptors that serve as iron ion chaperones in the cytosolic/nuclear compartment, binding iron at import and delivering it to enzymes, for storage (ferritin) and export (ferroportin). Ferritin iron is mobilized by autophagy through the cargo receptor, nuclear co-activator 4. The monothiol glutaredoxin Glrx3 and BolA2 function as a [2Fe-2S] chaperone complex. These proteins form a core system of cytosolic iron cofactor chaperones in mammalian cells.
RFID-Enabled Business Process Intelligence in Retail Stores: A Case Report

The growing interest in Radio Frequency Identification (RFID) technology in recent years has sparked an intensive debate on the benefits to be expected. With the growth of RFID implementations in size and scope comes a shift away from infrastructural aspects to the question of how to draw value from the large amounts of collected data. However, the necessary procedures for the handling of massive RFID data sets are still an under-researched issue. Against this background, the study presents results from a real-world trial conducted by a large apparel retailer. The objective of the trial was to explore the opportunities for generating novel performance indicators and reports on the reality of store processes and customer behavior on the sales floor. We give an overview of the algorithms used for RFID data processing and the interpretation of the resulting insights from a practitioner's point of view. The case example thus provides an overview of the potential of RFID as a powerful tool for assortment optimization, customer research, store layout design, and other management tasks in retail.
The Influence Of Accounting Knowledge, Socialization Of Accounting Standards, Education And Business Scale On The Quality Of Financial Statements (Study on SME in Bengkulu City)

The development of SME in Bengkulu City is increasing from year to year, but in running their business, SMEs rarely make financial statements in accordance with SAK EMKM, this is due to the low accounting knowledge and education possessed by SME. In addition, it is very rare for socialization about SAK EMKM by the government. Business size will also affect SME in improving the quality of financial statements. This study aims to determine the influence of accounting knowledge, socialization of accounting standards, education and business scale on the quality of financial statements in SME in Bengkulu City. Data collection was done by questionnaire and data analysis using multiple linear regression analysis and hypothesis test. The sample in this study was 88 SME in the city of Bengkulu. The results showed that accounting knowledge, socialization of accounting standards and business scale had a significant partial effect on the quality of financial statements because the quality of financial statements could be improved due to accounting knowledge from SME and socialization from the government about SAK EKM and business scale. However, the variable level of education does not have a significant effect on the quality of financial statements because high education does not guarantee that someone can produce quality financial statements, without high education, SME can find out about the quality of good financial statements through socialization and training
PPR596 Is Required for nad2 Intron Splicing and Complex I Biogenesis in Arabidopsis

Mitochondria are essential organelles that generate energy via oxidative phosphorylation. Plant mitochondrial genome encodes some of the respiratory complex subunits, and these transcripts require accurate processing, including C-to-U RNA editing and intron splicing. Pentatricopeptide repeats (PPR) proteins are involved in various organellar RNA processing events. PPR596, a P-type PPR protein, was previously identified to function in the C-to-U editing of mitochondrial rps3 transcripts in Arabidopsis. Here, we demonstrate that PPR596 functions in the cis-splicing of nad2 intron 3 in mitochondria. Loss of the PPR596 function affects the editing at rps3eU1344SS, impairs nad2 intron 3 splicing and reduces the mitochondrial complex I’s assembly and activity, while inducing alternative oxidase (AOX) gene expression. This defect in nad2 intron splicing provides a plausible explanation for the slow growth of the ppr595 mutants. Although a few P-type PPR proteins are involved in RNA C-to-U editing, our results suggest that the primary function of PPR596 is intron splicing.
Adenosine Receptor-Mediated Adhesion of Endothelial Progenitors to Cardiac Microvascular Endothelial Cells

Intracoronary delivery of endothelial progenitor cells (EPCs) is an emerging concept for the treatment of cardiovascular disease. Enhancement of EPC adhesion to vascular endothelium could improve cell retention within targeted organs. Because extracellular adenosine is elevated at sites of ischemia and stimulates neovascularization, we examined the potential role of adenosine in augmenting EPC retention to cardiac microvascular endothelium. Stimulation of adenosine receptors in murine embryonic EPCs (eEPCs) and cardiac endothelial cells (cECs) rapidly, within minutes, increased eEPC adhesion to cECs under static and flow conditions. Similarly, adhesion of human adult culture-expanded EPCs to human cECs was increased by stimulation of adenosine receptors. Furthermore, adenosine increased eEPC retention in isolated mouse hearts perfused with eEPCs. We determined that eEPCs and cECs preferentially express functional A1 and A2B adenosine receptor subtypes, respectively, and that both subtypes are involved in the regulation of eEPC adhesion to cECs. We documented that the interaction between P-selectin and its ligand (P-selectin glycoprotein ligand-1) plays a role in adenosine-dependent eEPC adhesion to cECs and that stimulation of adenosine receptors in cECs induces rapid cell surface expression of P-selectin. Our results suggest a role for adenosine in vasculogenesis and its potential use to stimulate engraftment in cell-based therapies.
Manufacturing test of SoCs

In this paper the solution the industry is driving towards for manufacturing test of SoCs is described. The quality of test for every core that is integrated on the chip is very important to the overall quality of the SoC. In this paper a method for evaluating the quality needs of an embedded core relative to the embedded environment is presented. Due to the partitioning of the test data and the increased stress in quality for individual designs the test application time is increasing. This paper presents the problems associated with test application time with SoCs.
Elliptic Curve Point Multiplication in GF(2n) using Polynomial Residue Arithmetic

Elliptic Curve Point Multiplication is the main operation employed in all elliptic curve cryptosystems, as it forms the basis of the Elliptic Curve Discrete Logarithm Problem. Therefore, the efficient realization of an Elliptic Curve Point Multiplier is of fundamental importance, as its performance is decisive for the performance of the overall cryptosystem. This work presents the first practical implementation of an Elliptic Curve Point Multiplier in GF(2n) using Polynomial Residue Arithmetic. Unlike the typical representation of GF(2n) elements as polynomials in GF(2)[x] of degree at most n − 1, data are represented as their remainder modulo a set of L pairwise prime polynomials m1,m2, … ,mL of degree w and such that Lw ≥ 2n. The methodology for incorporating Polynomial Residue Arithmetic in the elliptic curve point addition and doubling algorithms, as well as the VLSI architecture of the proposed point multiplier are analyzed, thus forming an interesting alternative to Elliptic Curve Cryptography realization.
Particle systems—a technique for modeling a class of fuzzy objects

This paper introduces particle systems-a method for modeling fuzzy objects such as fire, clouds, and water. Particle systems model an object as a cloud of primitive particles that define its volume. Over a period of time, particles are generated into the system, move and change form within the system, and die from the system. The resulting model is able to represent motion, changes of form, and dynamics that are not possible with classical surface-based representations. The particles can easily be motion blurred, and therefore do not exhibit temporal aliasing or strobing. Stochastic processes are used to generate and control the many particles within a particle system. The application of particle systems to the wall of fire element from the Genesis Demo sequence of the film Star Trek II: The Wrath of Khan [10] is presented.
Slime Mold Solves Maze in One Pass, Assisted by Gradient of Chemo-Attractants

Plasmodium of Physarum polycephalum is a large cell, visible by unaided eye, which exhibits sophisticated patterns of foraging behaviour. The plasmodium's behaviour is well interpreted in terms of computation, where data are spatially extended configurations of nutrients and obstacles, and results of computation are networks of protoplasmic tubes formed by the plasmodium. In laboratory experiments and numerical simulation we show that if plasmodium of P. polycephalum is inoculated in a maze's peripheral channel and an oat flake (source of attractants) in a the maze's central chamber then the plasmodium grows toward target oat flake and connects the flake with the site of original inoculation with a pronounced protoplasmic tube. The protoplasmic tube represents a path in the maze. The plasmodium solves maze in one pass because it is assisted by a gradient of chemo-attractants propagating from the target oat flake.