Miracle-dz/UniFAR-FTUs huggingface dataset:
Probabilistic frequent itemset mining in uncertain databases

Probabilistic frequent itemset mining in uncertain transaction databases semantically and computationally differs from traditional techniques applied to standard "certain" transaction databases. The consideration of existential uncertainty of item(sets), indicating the probability that an item(set) occurs in a transaction, makes traditional techniques inapplicable. In this paper, we introduce new probabilistic formulations of frequent itemsets based on possible world semantics. In this probabilistic context, an itemset X is called frequent if the probability that X occurs in at least minSup transactions is above a given threshold τ. To the best of our knowledge, this is the first approach addressing this problem under possible worlds semantics. In consideration of the probabilistic formulations, we present a framework which is able to solve the Probabilistic Frequent Itemset Mining (PFIM) problem efficiently. An extensive experimental evaluation investigates the impact of our proposed techniques and shows that our approach is orders of magnitude faster than straight-forward approaches.
Colonic lesion characterization in inflammatory bowel disease: A systematic review and meta-analysis

AIM To perform a systematic review and meta-analysis for the diagnostic accuracy of in vivo lesion characterization in colonic inflammatory bowel disease (IBD), using optical imaging techniques, including virtual chromoendoscopy (VCE), dye-based chromoendoscopy (DBC), magnification endoscopy and confocal laser endomicroscopy (CLE). METHODS We searched Medline, Embase and the Cochrane library. We performed a bivariate meta-analysis to calculate the pooled estimate sensitivities, specificities, positive and negative likelihood ratios (+LHR, -LHR), diagnostic odds ratios (DOR), and area under the SROC curve (AUSROC) for each technology group. A subgroup analysis was performed to investigate differences in real-time non-magnified Kudo pit patterns (with VCE and DBC) and real-time CLE. RESULTS We included 22 studies [1491 patients; 4674 polyps, of which 539 (11.5%) were neoplastic]. Real-time CLE had a pooled sensitivity of 91% (95%CI: 66%-98%), specificity of 97% (95%CI: 94%-98%), and an AUSROC of 0.98 (95%CI: 0.97-0.99). Magnification endoscopy had a pooled sensitivity of 90% (95%CI: 77%-96%) and specificity of 87% (95%CI: 81%-91%). VCE had a pooled sensitivity of 86% (95%CI: 62%-95%) and specificity of 87% (95%CI: 72%-95%). DBC had a pooled sensitivity of 67% (95%CI: 44%-84%) and specificity of 86% (95%CI: 72%-94%). CONCLUSION Real-time CLE is a highly accurate technology for differentiating neoplastic from non-neoplastic lesions in patients with colonic IBD. However, most CLE studies were performed by single expert users within tertiary centres, potentially confounding these results.
Cocaine cue-induced dopamine release in the human prefrontal cortex.

BACKGROUND Accumulating evidence indicates that drug-related cues can induce dopamine (DA) release in the striatum of substance abusers. Whether these same cues provoke DA release in the human prefrontal cortex remains unknown. METHODS We used high-resolution positron emission tomography with [18F]fallypride to measure cortical and striatal DA D2/3 receptor availability in the presence versus absence of drug-related cues in volunteers with current cocaine dependence. RESULTS Twelve individuals participated in our study. Among participants reporting a craving response (9 of 12), exposure to the cocaine cues significantly decreased [18F]fallypride binding potential (BPND) values in the medial orbitofrontal cortex and striatum. In all 12 participants, individual differences in the magnitude of craving correlated with BPND changes in the medial orbitofrontal cortex, dorsolateral prefrontal cortex, anterior cingulate, and striatum. Consistent with the presence of autoreceptors on mesostriatal but not mesocortical DA cell bodies, midbrain BPND values were significantly correlated with changes in BPND within the striatum but not the cortex. The lower the midbrain D2 receptor levels, the greater the striatal change in BPND and self-reported craving. LIMITATIONS Limitations of this study include its modest sample size, with only 2 female participants. Newer tracers might have greater sensitivity to cortical DA release. CONCLUSION In people with cocaine use disorders, the presentation of drug-related cues induces DA release within cortical and striatal regions. Both effects are associated with craving, but only the latter is regulated by midbrain autoreceptors. Together, the results suggest that cortical and subcortical DA responses might both influence drug-focused incentive motivational states, but with separate regulatory mechanisms.
Agricultural Growth and Poverty Reduction: Additional Evidence

Agricultural growth has long been recognized as an important instrument for poverty reduction. Yet, measurements of this relationship are still scarce and not always reliable. The authors present additional evidence at both the sectoral and household levels based on recent data. Results show that rural poverty reduction has been associated with growth in yields and in agricultural labor productivity, but that this relation varies sharply across regional contexts. Gross domestic product (GDP) growth originating in agriculture induces income growth among the 40 percent poorest, which is on the order of three times larger than growth originating in the rest of the economy. The power of agriculture comes not only from its direct poverty reduction effect but also from its potentially strong growth linkage effects on the rest of the economy. Decomposing the aggregate decline in poverty into a rural contribution, an urban contribution, and a population shift component shows that rural areas contributed more than half the observed aggregate decline in poverty. Finally, using the example of Vietnam, the authors show that rapid growth in agriculture has opened pathways out of poverty for farming households. While the effectiveness of agricultural growth in reducing poverty is well established, the effectiveness of public investment in inducing agricultural growth is still incomplete and conditional on context.
Pulmonary Arteriovenous Malformations and Cerebral Abscess Recurrence in a Child With Hereditary Hemorrhagic Telangiectasia

Background: A 17-year-old boy was referred to our center with a history of brain abscess (BA) recurring after 9 years. The patient reported 2 previous treatments for pulmonary arteriovenous malformations, sporadic nosebleeds, and familial history for epistaxis. Clinical investigations revealed arteriovenous malformations in lung, brain, and liver, as well as mucocutaneous telangiectases. A definite diagnosis of hereditary hemorrhagic telangiectasia was made based on clinical criteria and confirmed by genetic analysis. This is the first report of BA recurrence at the end of pediatric age. Conclusions: The present case and the literature review of all cases of BA thus far reported highlight the need to raise the suspicion of a pulmonary arteriovenous malformations, both isolated and in the context of a possible hereditary hemorrhagic telangiectasia, for any case of BA of unexplained etiology, in children as well as in adults.
The effect of stress on core and peripheral body temperature in humans

Abstract Even though there are indications that stress influences body temperature in humans, no study has systematically investigated the effects of stress on core and peripheral body temperature. The present study therefore aimed to investigate the effects of acute psychosocial stress on body temperature using different readout measurements. In two independent studies, male and female participants were exposed to a standardized laboratory stress task (the Trier Social Stress Test, TSST) or a non-stressful control task. Core temperature (intestinal and temporal artery) and peripheral temperature (facial and body skin temperature) were measured. Compared to the control condition, stress exposure decreased intestinal temperature but did not affect temporal artery temperature. Stress exposure resulted in changes in skin temperature that followed a gradient-like pattern, with decreases at distal skin locations such as the fingertip and finger base and unchanged skin temperature at proximal regions such as the infra-clavicular area. Stress-induced effects on facial temperature displayed a sex-specific pattern, with decreased nasal skin temperature in females and increased cheek temperature in males. In conclusion, the amplitude and direction of stress-induced temperature changes depend on the site of temperature measurement in humans. This precludes a direct translation of the preclinical stress-induced hyperthermia paradigm, in which core temperature uniformly rises in response to stress to the human situation. Nevertheless, the effects of stress result in consistent temperature changes. Therefore, the present study supports the inclusion of body temperature as a physiological readout parameter of stress in future studies.
Thermodynamic and kinetic study of the intrinsic adsorption capacity of graphene oxide for malachite green removal from aqueous solution

Graphene oxide (GO) was produced from bare graphite (BGP) material and was used as an intrinsic adsorbent for the removal of malachite green (MG) from aqueous solution. In an optimization study, the effects of the initial concentration of MG, solution pH, adsorbent dosage, contact time and ionic strength were investigated in detail. The water-soluble dye was analyzed at a maximum wavelength of 618 nm. The optimum conditions for MG removal from aqueous solution included a 300 mg/L initial concentration with 0.02 mg adsorbent at pH 5.1, and complete adsorption equilibrium was reached within 40 min. The maximum adsorption capacity of GO for MG was 384.62 mg/g, dramatically higher (over 10 times) than that of BGP (28.73 mg/g). The adsorption process followed pseudo-second-order kinetics. Thermodynamic data demonstrated that dye adsorption onto the GO surface was mainly an exothermic spontaneous reaction. The remarkably different adsorption isotherms for GO and BGP fit well with the Langmuir and Freundlich models, respectively. It is therefore evident that the prepared GO can be used as a highly effective adsorbent for this toxic dye.
Extracting bottleneck features and word-like pairs from untranscribed speech for feature representation

We propose a framework to learn a frame-level speech representation in a scenario where no manual transcription is available. Our framework is based on pairwise learning using bottleneck features (BNFs). Initial frame-level features are extracted from a bottleneck-shaped multilingual deep neural network (DNN) which is trained with unsupervised phoneme-like labels. Word-like pairs are discovered in the untranscribed speech using the initial features, and frame alignment is performed on each word-like speech pair. The matching frame pairs are used as input-output to train another DNN with the mean square error (MSE) loss function. The final frame-level features are extracted from an internal hidden layer of MSE-based DNN. Our pairwise learned feature representation is evaluated on the ZeroSpeech 2017 challenge. The experiments show that pairwise learning improves phoneme discrimination in 10s and 120s test conditions. We find that it is important to use BNFs as initial features when pairwise learning is performed. With more word pairs obtained from the Switchboard corpus and its manual transcription, the phoneme discrimination of three languages in the evaluation data can further be improved despite data mismatch.
Localized versus itinerant states created by multiple oxygen vacancies in SrTiO3

Oxygen vacancies in strontium titanate surfaces (SrTiO3) have been linked to the presence of a two-dimensional electron gas with unique behavior. We perform a detailed density functional theory study of the lattice and electronic structure of SrTiO3 slabs with multiple oxygen vacancies, with a main focus on two vacancies near a titanium dioxide terminated SrTiO3 surface. We conclude based on total energies that the two vacancies preferably inhabit the first two layers, i.e. they cluster vertically, while in the direction parallel to the surface, the vacancies show a weak tendency towards equal spacing. Analysis of the nonmagnetic electronic structure indicates that oxygen defects in the surface TiO2 layer lead to population of Ti t 2 g ? > states and thus itinerancy of the electrons donated by the oxygen vacancy. In contrast, electrons from subsurface oxygen vacancies populate Ti eg states and remain localized on the two Ti ions neighboring the vacancy. We find that both the formation of a bound oxygen-vacancy state composed of hybridized Ti 3eg and 4p states neighboring the oxygen vacancy as well as the elastic deformation after extracting oxygen contribute to the stabilization of the in-gap state.
Learning Less is More - 6D Camera Localization via 3D Surface Regression

Popular research areas like autonomous driving and augmented reality have renewed the interest in image-based camera localization. In this work, we address the task of predicting the 6D camera pose from a single RGB image in a given 3D environment. With the advent of neural networks, previous works have either learned the entire camera localization process, or multiple components of a camera localization pipeline. Our key contribution is to demonstrate and explain that learning a single component of this pipeline is sufficient. This component is a fully convolutional neural network for densely regressing so-called scene coordinates, defining the correspondence between the input image and the 3D scene space. The neural network is prepended to a new end-to-end trainable pipeline. Our system is efficient, highly accurate, robust in training, and exhibits outstanding generalization capabilities. It exceeds state-of-the-art consistently on indoor and outdoor datasets. Interestingly, our approach surpasses existing techniques even without utilizing a 3D model of the scene during training, since the network is able to discover 3D scene geometry automatically, solely from single-view constraints.
Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study

Objectives The objectives of this study were to examine changes in the incidence and prevalence of RA between 1990 and 2014 and to explore if there is any geographic variation in the incidence and prevalence of RA in the UK. Methods This was a primary care-based prospective cohort study. People contributing acceptable data to Clinical Practice Research Datalink between 1 January 1990 and 31 December 2014 were included. Read codes were used to identify RA cases ⩾18 years of age. The prevalence and incidence rates for each year were standardized to the 2014 population and the regional incidence and prevalence of RA for the year 2014 were standardized to the overall population. Results The incidence and prevalence of RA was 3.81/10 000 person-years and 0.67%, respectively, in 2014. The annual incidence of RA decreased by 1.6% (95% CI 0.8, 2.5) between 1990 and 2014, with significant joinpoints at 1994 and 2002. The prevalence of RA increased by 3.7%/year (95% CI 3.2, 4.1) from 1990 to 2005 and decreased by 1.1%/year (95% CI 2.0, 0.2) between 2005 and 2014. There were significant differences in the occurrence of RA throughout different regions of the UK, with the highest incidence in East Midlands, Yorkshire and Humber and the highest prevalence in North East, Yorkshire and Humber. Conclusion The incidence of RA is decreasing, with a reduction in prevalence in recent years. There is significant geographic variation in the occurrence of RA in the UK. Further research is required to identify the reasons underlying this phenomenon so that public health interventions can be designed to further reduce the incidence of RA.
Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

Significance Mitochondrial function is supported by dynamic quality control processes, such as mitochondrial fusion. Cardiac contractility depends on mitochondrial metabolism, yet in cardiomyocytes, mitochondria are confined among myofibrils, raising questions about the possibility of mitochondrial physical communication. Here we demonstrate that mitochondrial continuity is robust and fusion is frequent in freshly isolated rat ventricular myocytes, manifesting both as rapid content mixing events between adjacent organelles and slower, often long-distance events. We show that mitochondrial fusion decreases dramatically in culture because of the decay in contractile activity and, more specifically, the underlying calcium oscillations, which involve mitofusin 1 (Mfn1) abundance. In addition, we show that attenuation of cardiac contractility in vivo in alcoholic animals is also associated with depressed mitochondrial fusion. Mitochondrial fusion is thought to be important for supporting cardiac contractility, but is hardly detectable in cultured cardiomyocytes and is difficult to directly evaluate in the heart. We overcame this obstacle through in vivo adenoviral transduction with matrix-targeted photoactivatable GFP and confocal microscopy. Imaging in whole rat hearts indicated mitochondrial network formation and fusion activity in ventricular cardiomyocytes. Promptly after isolation, cardiomyocytes showed extensive mitochondrial connectivity and fusion, which decayed in culture (at 24–48 h). Fusion manifested both as rapid content mixing events between adjacent organelles and slower events between both neighboring and distant mitochondria. Loss of fusion in culture likely results from the decline in calcium oscillations/contractile activity and mitofusin 1 (Mfn1), because (i) verapamil suppressed both contraction and mitochondrial fusion, (ii) after spontaneous contraction or short-term field stimulation fusion activity increased in cardiomyocytes, and (iii) ryanodine receptor-2–mediated calcium oscillations increased fusion activity in HEK293 cells and complementing changes occurred in Mfn1. Weakened cardiac contractility in vivo in alcoholic animals is also associated with depressed mitochondrial fusion. Thus, attenuated mitochondrial fusion might contribute to the pathogenesis of cardiomyopathy.
Infrared Image Enhancement in Maritime Environment with Convolutional Neural Networks

Image enhancement approach with Convolutional Neural Network (CNN) for infrared (IR) images from maritime environment, is proposed in this paper. The approach includes different CNNs to improve the resolution and to reduce noise artefacts in maritime IR images. The denoising CNN employs a residual architecture which is trained to reduce graininess and fixed pattern noise. The super-resolution CNN employs a similar architecture to learn the mapping from a low-resolution to multi-scale high-resolution images. The performance of the CNNs is evaluated on the IR test dataset with standard evaluation methods and the evaluation results show an overall improvement in the quality of the IR images.
Diphenhydramine as a selective probe to study H+-antiporter function at the blood–brain barrier: Application to [11C]diphenhydramine positron emission tomography imaging

Diphenhydramine, a sedative histamine H1-receptor (H1R) antagonist, was evaluated as a probe to measure drug/H+-antiporter function at the blood–brain barrier. In situ brain perfusion experiments in mice and rats showed that diphenhydramine transport at the blood–brain barrier was saturable, following Michaelis–Menten kinetics with a Km = 2.99 mM and Vmax = 179.5 nmol s−1 g−1. In the pharmacological plasma concentration range the carrier-mediated component accounted for 77% of diphenhydramine influx while passive diffusion accounted for only 23%. [14C]Diphenhydramine blood–brain barrier transport was proton and clonidine sensitive but was influenced by neither tetraethylammonium, a MATE1 (SLC47A1), and OCT/OCTN (SLC22A1-5) modulator, nor P-gp/Bcrp (ABCB1a/1b/ABCG2) deficiency. Brain and plasma kinetics of [11C]diphenhydramine were measured by positron emission tomography imaging in rats. [11C]Diphenhydramine kinetics in different brain regions were not influenced by displacement with 1 mg kg−1 unlabeled diphenhydramine, indicating the specificity of the brain positron emission tomography signal for blood–brain barrier transport activity over binding to any central nervous system target in vivo. [11C]Diphenhydramine radiometabolites were not detected in the brain 15 min after injection, allowing for the reliable calculation of [11C]diphenhydramine brain uptake clearance (Clup = 0.99 ± 0.18 mL min−1 cm−3). Diphenhydramine is a selective and specific H+-antiporter substrate. [11C]Diphenhydramine positron emission tomography imaging offers a reliable and noninvasive method to evaluate H+-antiporter function at the blood–brain barrier.
The Role of Quinine-Responsive Taste Receptor Family 2 in Airway Immune Defense and Chronic Rhinosinusitis

Background Bitter (T2R) and sweet (T1R) taste receptors in the airway are important in innate immune defense, and variations in taste receptor functionality in one T2R (T2R38) correlate with disease status and disease severity in chronic rhinosinusitis (CRS). Quinine is a bitter compound that is an agonist for several T2Rs also expressed on sinonasal cells, but not for T2R38. Because of this property, quinine may stimulate innate immune defense mechanisms in the airway, and functional differences in quinine perception may be reflective of disease status in CRS. Methods Demographic and taste intensity data were collected prospectively from CRS patients and non-CRS control subjects. Sinonasal tissue from patients undergoing rhinologic surgery was also collected and grown at an air–liquid interface (ALI). Nitric oxide (NO) production and dynamic regulation of ciliary beat frequency in response to quinine stimulation were assessed in vitro. Results Quinine reliably increased ciliary beat frequency and NO production in ALI cultures in a manner consistent with T2R activation (p < 0.01). Quinine taste intensity rating was performed in 328 CRS patients and 287 control subjects demonstrating that CRS with nasal polyps (CRSwNP) patients rated quinine as significantly less intense than did control subjects. Conclusion Quinine stimulates airway innate immune defenses by increasing ciliary beat frequency and stimulating NO production in a manner fitting with T2R activation. Patient variability in quinine sensitivity is observed in taste intensity ratings, and gustatory quinine “insensitivity” is associated with CRSwNP status. Thus, taste tests for quinine may be a biomarker for CRSwNP, and topical quinine has therapeutic potential as a stimulant of innate defenses.
Barriers in the adoption of a market orientation by locally based non-profit organisations (NPOs)

The need for non-profit organisations (NPOs) to adopt a ‘market orientation’ has been promoted widely in the academic literature. To date, research in this area has focussed on either measuring the degree of market orientation within an NPO or detailing the financial and other benefits that accrue from a market orientation. Although this body of research acknowledges there are barriers to the adoption of a market orientation no study has identified the nature of these barriers. This study contributes to our knowledge by identifying what managers of small locally based NPOs perceive as the main barriers to the adoption of a market orientation. Barriers to the adoption of a market orientation were identified through a qualitative study that included the development of eight case studies. In the cases studied the greatest barrier to the adoption of a market orientation by an NPO was its size (as measured by staff numbers). The larger the NPO the less difficulty it has adopting a market orientation. However, two other factors can also influence the adoption of a market orientation. These are: organisational dynamics and individual leadership. This paper discusses each of these factors and concludes by suggesting avenues for further research.