Miracle-dz/UniFAR-FTUs huggingface dataset:
Endogenous Intermediation in Over-the-Counter Markets

We provide a theory of trading through intermediaries in OTC markets. The role of intermediaries is to sustain unsecured trade. When agents trade without collateral, total surplus can increase. In our model, traders are connected through a network. Agents observe their neighbors' actions, and can trade with their counterparty in a given period through a path of intermediaries in the network. If trade is unsecured, agents can renege on their obligations. We show that trading through a network is essential to support unsecured trade, when agents infrequently meet the same counterparty in the market. However, intermediaries must receive fees to have the incentive to implement unsecured trades. While trade without collateral can be sustained in many networks, the efficiency gains are higher in a star network. The center agent in a star can receive higher fees as well. Moreover, concentrated intermediation is a stable structure, when agents incur linking costs.
Named Entity Recognition with a Maximum Entropy Approach

The named entity recognition (NER) task involves identifying noun phrases that are names, and assigning a class to each name. This task has its origin from the Message Understanding Conferences (MUC) in the 1990s, a series of conferences aimed at evaluating systems that extract information from natural language texts. It became evident that in order to achieve good performance in information extraction, a system needs to be able to recognize names. A separate subtask on NER was created in MUC-6 and MUC-7 (Chinchor, 1998).
EPIDEMIOLOGY OF LATENCY AND RELAPSE IN PLASMODIUM VIVAX MALARIA

Malaria is a major contributor to health burdens throughout the regions where it is endemic. Historically, it was believed that there was limited morbidity and essentially no mortality associated with Plasmodium vivax; however, evidence from diverse settings now suggests that infections with P. vivax can be both severe and fatal. This awareness has highlighted a critical gap: the vast majority of research has been directed towards P. falciparum, leading to a decades-long neglect of epidemiological and clinical studies of P. vivax. There exists a large body of historical data on human experimental infections with P. vivax; these studies in controlled settings provided a wealth of wide-ranging statements based on expert opinion, which form the basis for much of what is currently known about P. vivax. In this thesis, portions of this evidence-base have been re-examined using modern epidemiological analyses with two aims: to critically examine this accumulated knowledge base, and to inform current research agendas towards global malaria elimination for all species of Plasmodium. Chapter 2 examines geographic variation in the epidemiology of P. vivax, especially the timing of incubation periods and of relapses, by origin of the parasites. Chapter 3 re-assesses the impact of sporozoite dosage upon incubation and pre-patent periods; Chapter 4 provides well-defined mathematical distributions for incubation and relapses periods in experimental infections, and explores their epidemiological impacts using simple transmission models. Chapter 5 examines the epidemiology of mixed-strain P. vivax infections and compares these results with studies in murine models and general ecological theory; and Chapter 6 clarifies the origin of the Madagascar strain of P. vivax.
Are historical records sufficient to constrain ENSO simulations?

A control simulation of the GFDL CM2.1 global coupled GCM, run for 2000 years with its atmospheric composition, solar irradiance, and land cover held fixed at 1860 values, exhibits strong interdecadal and intercentennial modulation of its ENSO behavior. To the extent that such modulation is realistic, it could attach large uncertainties to ENSO metrics diagnosed from centennial and shorter records – with important implications for historical and paleo records, climate projections, and model assessment and intercomparison. Analysis of the wait times between ENSO warm events suggests that such slow modulation need not require multidecadal memory; it can arise simply from Poisson statistics applied to ENSO's interannual time scale and seasonal phase‐locking.
The distribution of output in integrated economies: theory and evidence

We show that in a fully integrated economy, in which there is free mobility of goods and factors, each member’s share of total output will equal its shares of total stocks of productive factors (i.e., physical and human capital). We label this result the equal-share relationship. This relationship also holds in the presence of technological differences or costs of factor mobility among members if outputs or inputs are properly measured to reflect such differences or costs. The equal-share relationship is the limiting distribution of output and factors among members of a fully integrated economy, and it constraints the set of policies that can affect each member’s relative growth within an integrated economy. We empirically examine for the equal-share relationship for alternative economic groups (i.e., US states, EU countries, Developing Countries and a World comprising 55 countries). Our findings indicate that the equal-share relationship holds strongly for US states, holds weakly for EU countries, but does not hold for Developing Countries or the World.
Characteristics of Diffuse X-Ray Line Emission within 20 Parsecs of the Galactic Center

Over the last three years, the Galactic center region has been monitored with the Chandra X-Ray Observatory. Besides the X-ray emission from the target object, Sgr A*, diffuse X-ray emission was detected throughout most of the 17′ × 17′ field of view. With 11 Chandra observations through 2002 June, the total effective exposure reaches ~590 ks, providing significant photon statistics on much of the detailed structure within the faint, often filamentary, diffuse X-ray emission. The true-color X-ray image and the equivalent-width images for the detected elemental species of the Galactic center region demonstrate that the diffuse X-ray features have a broad range of spatiospectral properties. Enhancements of the low ionization state Fe line emission (E ~ 6.4 keV) to the northeast of Sgr A* can be interpreted as fluorescence within the dense interstellar medium resulting from irradiation by hard, external X-ray sources. They may also be explained by emission induced by the bombardments by high-energy particles on the ambient medium, such as may accompany unresolved supernova ejecta intruding into dense interstellar medium. The detection of molecular cloud counterparts to the 6.4 keV Fe line-emitting features indicates that these Fe line features are associated with dense Galactic center clouds and/or active star-forming regions, which strongly supports the proposed origins of the X-ray reflection and/or supernova ejecta for the Fe line emission. We detect highly ionized S and Si lines that are generally coincident with the low ionization state Fe line emission and the dense molecular clouds in the northeast of Sgr A*. These hot plasmas are then most likely produced by massive star-forming activities and/or supernova remnants in the Galactic center. In contrast, we find that highly ionized He-like Fe line emission (E ~ 6.7 keV) is primarily distributed along the plane instead of being concentrated in the northeast of Sgr A*. The implied high temperature and the relatively uniform, but strong, alignment along the plane are consistent with the magnetic-confinement model, suggesting that this hot gas component has been reheated by the strong interstellar magnetic fields in the Galactic center to produce the observed He-like Fe line emission.
LIS1, CLIP-170's Key to the Dynein/Dynactin Pathway

ABSTRACT CLIP-170 is a plus-end tracking protein which may act as an anticatastrophe factor. It has been proposed to mediate the association of dynein/dynactin to microtubule (MT) plus ends, and it also binds to kinetochores in a dynein/dynactin-dependent fashion, both via its C-terminal domain. This domain contains two zinc finger motifs (proximal and distal), which are hypothesized to mediate protein-protein interactions. LIS1, a protein implicated in brain development, acts in several processes mediated by the dynein/dynactin pathway by interacting with dynein and other proteins. Here we demonstrate colocalization and direct interaction between CLIP-170 and LIS1. In mammalian cells, LIS1 recruitment to kinetochores is dynein/dynactin dependent, and recruitment there of CLIP-170 is dependent on its site of binding to LIS1, located in the distal zinc finger motif. Overexpression of CLIP-170 results in a zinc finger-dependent localization of a phospho-LIS1 isoform and dynactin to MT bundles, raising the possibility that CLIP-170 and LIS1 regulate dynein/dynactin binding to MTs. This work suggests that LIS1 is a regulated adapter between CLIP-170 and cytoplasmic dynein at sites involved in cargo-MT loading, and/or in the control of MT dynamics.
Appalachian Bridges to the Baccalaureate: How Community Colleges Affect Transfer Success.

OF DISSERTATION APPALACHIAN BRIDGES TO THE BACCALAUREATE: HOW COMMUNITY COLLEGES AFFECT TRANSFER SUCCESS Statement of the problem. Too few community college students who intend to transfer and earn a baccalaureate degree actually do. This is a problem because postsecondary education is a key factor in economic mobility, and community colleges enroll a disproportionate number of nontraditional, part-time and low-income students. Although individual factors must be considered by community colleges, they often are out of the control of the institution. This study focused on the institutional factors, including the ways that organizational structures contribute to the success of a community college’s transfer program. Design. This companion study was conducted by a four-member research team. In order to describe the transfer population and institutional characteristics, a quantitative analysis was conducted for the student population, which included 338 spring and summer 2009 Associate in Arts and/or Associate in Science (AA/AS) graduates from four Appalachian community colleges. This analysis indicated that individual student characteristics did not explain the differences in institutional transfer rates. Two of the institutions were identified as statistically significant institutions promoting transfer success. Students from these high-impact community colleges were found to be at least two times more likely to transfer than students attending the low-impact institutions. Each member of the research team looked at a different aspect of the transfer experiences of the cohort. Two components explored institutional perspectives by interviewing 27 faculty, staff, and leaders from the four community colleges. The other two components examined student perceptions of their community college transfer experiences. Major conclusions. One component of the companion study examined the interplay of informal and formal organizational structures of community colleges in the context of successful transfer. A typology model was created to illustrate the interface of structural elements that plays a role in the differentiation between high-impact and low-impact institutions. Findings indicated that two elements seem to make a difference in a
Can Mean Platelet Volume Serve as a Marker for Prostatitis?

Aim: The aim of the study was to compare the yield of mean platelet volume (MPV), total prostate specific antigen (tPSA), free prostate specific antigen (fPSA), f/t PSA ratio and complex prostate specific antigen (cPSA) in patients with prostatitis. Material and method: The study was designed in the Kayseri Education and Research Hospital. Ninety-six patients with prostatitis were enrolled retrospectively into the study. Laboratory data were obtained from the computerized patient database. We evaluated the correlation between tPSA, fPSa, f/t PSA ratio, cPSA, MPV and extent and aggressiveness of inflammation in the surgical specimens of patients who underwent surgery for benign prostatic hyperplasia (BPH). Inflammation in the prostatic tissues was scored for extent and aggressivity of inflammation using the grading system designed by Irani et al. Results: The total PSA, fPSa, f/t PSA ratio, cPSA and pre- and post-treatment MPV values of each group did not differ (p>0.05) (Table 1). Also there was no correlation between the histopathological grades and the MPV, tPSA, fPSA, f/t PSA ratio and cPSA of patients. However, MPV values significantly decreased after treatment in all grades of prostatitis (p<0.001). Conclusion: MPV values may be used as an inflammation marker in patients with prostatitis.
A Mimic of Tumor Rejection Antigen-Associated Carbohydrates Mediates an Antitumor Cellular Response

Tumor-associated carbohydrate antigens are typically perceived as inadequate targets for generating tumor-specific cellular responses. Lectin profile reactivity and crystallographic studies demonstrate that MHC class I molecules can present to the immune system posttranslationally modified cytosolic peptides carrying O-β-linked N-acetylglucosamine (GlcNAc). Here we report that a peptide surrogate of GlcNAc can facilitate an in vivo tumor-specific cellular response to established Meth A tumors that display native O-GlcNAc glycoproteins on the tumor cell surface. Peptide immunization of tumor-bearing mice had a moderate effect on tumor regression. Inclusion of interleukin 12 in the immunization regimen stimulated complete elimination of tumor cells in all of the mice tested, whereas interleukin 12 administration alone afforded no tumor growth inhibition. Adoptive transfer of immune T cells into tumor-bearing nude mice indicates a role for CD8+ T cells in tumor regression. This work postulates that peptide mimetics of glycosylated tumor rejection antigens might be further developed for immune therapy of cancer.
Multiple Regimes and Low-Frequency Oscillations in the Northern Hemisphere’s Zonal-Mean Flow

This paper studies multiple regimes and low-frequency oscillations in the Northern Hemisphere zonal-mean zonal flow in winter, using 55 yr of daily observational data. The probability density function estimated in the phase space spanned by the two leading empirical orthogonal functions exhibits two distinct, statistically significant maxima. The two regimes associated with these maxima describe persistent zonal-flow states that are characterized by meridional displacements of the midlatitude jet, poleward and equatorward of its time-mean position. The geopotential height anomalies of either regime have a pronounced zonally symmetric component, but largest-amplitude anomalies are located over the Atlantic and Pacific Oceans. High-frequency synoptic transients participate in the maintenance of and transitions between these regimes. Significant oscillatory components with periods of 147 and 72 days are identified by spectral analysis of the zonal-flow time series. These oscillations are described by singular spectrum analysis and the multitaper method. The 147-day oscillation involves zonal-flow anomalies that propagate poleward, while the 72-day oscillation only manifests northward propagation in the Atlantic sector. Both modes mainly describe changes in the midlatitude jet position and intensity. In the horizontal plane though, the two modes exhibit synchronous centers of action located over the Atlantic and Pacific Oceans. The two persistent flow regimes are associated with slow phases of either oscillation.
ON BADLY APPROXIMABLE NUMBERS AND CERTAIN GAMES

1. Introduction. A number a is called badly approximable if j a — p/q | > c/q2 for some c > 0 and all rationals pjq. It is known that an irrational number a is badly approximable if and only if the partial denominators in its continued fraction are bounded [4, Theorem 23]. In a recent paper [7] I proved results of the following type: // fuf2, • ■ • are differenliable functions whose derivatives are continuous and vanish nowhere, then there are continuum-many numbers a such that all the numbers fi(a),f2(a), • • • are badly approximable. Let 0<a<l/2, 0 < ß < 1, and consider the following game of two players black and white. First black picks a closed interval B¡. Then white picks a closed interval Wx c By whose length is a times the length of Bt. Then black chooses an interval B2 <= Wx which is closed and has length ß times the length of IF,. Then again white picks a closed interval W2 c B2 of length a times the length of B2, and so on. Call white the winner of a play if the intersection of the intervals W} is badly approximable; otherwise black is called the winner. Who will win? Since the badly approximable numbers have Lebesgue measure zero, [4, Theorem 29], one might think that black can always win. It turns out, however, that white can always win (Theorem 3). We shall show that sets S with this property (namely that white can always play such that the intersection [j W¡ is in S) necessarily contain continuum-many elements (Lemma 23), that countable intersections of sets with this property again have this property (Theorem 2), and that if S has this property, and f(x) has a continuous derivative with f'(x) # 0 everywhere, then the set of a with /(a) e S again has this property (Theorem 1). These facts imply the result stated at
Benchmarking OpenCL, OpenACC, OpenMP, and CUDA: programming productivity, performance, and energy consumption

Many modern parallel computing systems are heterogeneous at their node level. Such nodes may comprise general purpose CPUs and accelerators (such as, GPU, or Intel Xeon Phi) that provide high performance with suitable energy-consumption characteristics. However, exploiting the available performance of heterogeneous architectures may be challenging. There are various parallel programming frameworks (such as, OpenMP, OpenCL, OpenACC, CUDA) and selecting the one that is suitable for a target context is not straightforward. In this paper, we study empirically the characteristics of OpenMP, OpenACC, OpenCL, and CUDA with respect to programming productivity, performance, and energy. To evaluate the programming productivity we use our homegrown tool CodeStat, which enables us to determine the percentage of code lines required to parallelize the code using a specific framework. We use our tools MeterPU and x-MeterPU to evaluate the energy consumption and the performance. Experiments are conducted using the industry-standard SPEC benchmark suite and the Rodinia benchmark suite for accelerated computing on heterogeneous systems that combine Intel Xeon E5 Processors with a GPU accelerator or an Intel Xeon Phi co-processor.
Muscle residual force enhancement: a brief review

Muscle residual force enhancement has been observed in different muscle preparations for more than half a century. Nonetheless, its mechanism remains unclear; to date, there are three generally accepted hypotheses: 1) sarcomere length non-uniformity, 2) engagement of passive elements, and 3) an increased number of cross-bridges. The first hypothesis uses sarcomere non-homogeneity and instability to explain how “weak” sarcomeres would convey the higher tension generated by an enhanced overlap from “stronger” sarcomeres, allowing the whole system to produce higher forces than predicted by the force-length relationship; non-uniformity provides theoretical support for a large amount of the experimental data. The second hypothesis suggests that passive elements within the sarcomeres (i.e., titin) could gain strain upon calcium activation followed by stretch. Finally, the third hypothesis suggests that muscle stretch after activation would alter cross-bridge kinetics to increase the number of attached cross-bridges. Presently, we cannot completely rule out any of the three hypotheses. Different experimental results suggest that the mechanisms on which these three hypotheses are based could all coexist.
Discrete-time survival trees and forests with time-varying covariates

The aim of this paper is to propose a new survival tree method for discrete-time survival data with time-varying covariates. This method can accommodate simultaneously time-varying covariates and time-varying effects. The method is then used for bankruptcy analysis of US firms that conducted an Initial Public Offerings between 1990 and 1999 using accounting and financial ratios.
Nonlinear Parameter Estimation: Comparison of an Ensemble Kalman Smoother with a Markov Chain Monte Carlo Algorithm

AbstractThis paper explores the temporal evolution of cloud microphysical parameter uncertainty using an idealized 1D model of deep convection. Model parameter uncertainty is quantified using a Markov chain Monte Carlo (MCMC) algorithm. A new form of the ensemble transform Kalman smoother (ETKS) appropriate for the case where the number of ensemble members exceeds the number of observations is then used to obtain estimates of model uncertainty associated with variability in model physics parameters. Robustness of the parameter estimates and ensemble parameter distributions derived from ETKS is assessed via comparison with MCMC. Nonlinearity in the relationship between parameters and model output gives rise to a non-Gaussian posterior probability distribution for the parameters that exhibits skewness early and multimodality late in the simulation. The transition from unimodal to multimodal posterior probability density function (PDF) reflects the transition from convective to stratiform rainfall. ETKS-base.
IMPLICATIONS OF ULTRA–HIGH-ENERGY COSMIC RAYS FOR TRANSIENT SOURCES IN THE AUGER ERA

We study ultra–high-energy cosmic rays (UHECRs) from transient sources, propagating in the Galactic and intergalactic space. Based on recent observational results, we also estimate upper and lower bounds on the rate of transient UHECR sources and the required isotropic cosmic-ray energy input per burst as 0.1 Gpc−3 yr−1 ≲ ρ0 ≲ 103.5 Gpc−3 yr−1 and by constraining the apparent burst duration, i.e., dispersion in arrival times of UHECRs. Based on these bounds, we discuss implications for proposed candidates such as gamma-ray bursts and active galactic nuclei.
Reening Logical Characterizations of Advice Complexity Classes 1

Numerical relations in logics are known to characterize, via the nite models of their sentences, polynomial advice nonuniform complexity classes. These are known to coincide with reduction classes of tally sets. Our contributions here are: 1/ a reenement of that characterization that individualizes the reduction class of each tally set, and 2/ characterizing logarithmic advice classes via numerical constants, both in the (rather easy) case of C/log and in the more complex case of Full-C/log; this proof requires to extend to classes below P the technical characterizations known for the class Full-P/log.
Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue

We introduce a new, non-invasive, diffuse optical technique, speckle contrast optical spectroscopy (SCOS), for probing deep tissue blood flow using the statistical properties of laser speckle contrast and the photon diffusion model for a point source. The feasibility of the method is tested using liquid phantoms which demonstrate that SCOS is capable of measuring the dynamic properties of turbid media non-invasively. We further present an in vivo measurement in a human forearm muscle using SCOS in two modalities: one with the dependence of the speckle contrast on the source-detector separation and another on the exposure time. In doing so, we also introduce crucial corrections to the speckle contrast that account for the variance of the shot and sensor dark noises.