Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of Asymptomatic Bacteriuria among Pregnant Women Attending Antenatal Clinic at Federal Medical Centre Nguru Yobe State

Microbial colonization of the urine and tissue invasion of any structure of urinary tract is referred to as urinary tract infections (UTIs). Pregnancy enhances the progression of infections from asymptomatic to symptomatic which could lead to adverse obstetric outcomes such as premature birth, low birth weight, still birth and pyelonephritis. This study was undertaken to determine the prevalence of asymptomatic bacteriuria among pregnant women attending antenatal clinic at Federal Medical Centre Nguru (FMC), Yobe State. A total of three hundred patients agreed to participate in the research and their sample of urine were collected in separate containers. Out of the three hundred urine samples processed, 130 (43.3%) showed a significant bacteriuria growth, the most common isolate was Escherichia coli (36.9%), followed by Staphylococcus spp. (22.3%), Klebsiella spp. (20.0%), Proteus spp. (6.2%), Pseudomonas spp. (3.1%) and Streptococcus fecalis (11.5%). To prevent asymptomatic bacteriuria complication, all pregnant women should be screened at the first antenatal visit, and proper treatment must be considered as an essential part of antenatal care in FMC Nguru
Effects of water addition to total mixed ration on water intake, nutrient digestibility, wool cortisol and blood indices in Corriedale ewes

Objective The objective of this study was to determine the effect of adding water to total mixed ration (TMR) on fresh water intake, nutrient digestibility, wool cortisol, and blood indices in Corriedale ewes under hot and humid conditions. Methods Nine non-pregnant Corriedale ewes (ave. body weight = 41±3.5 kg) were individually fed diets based on maintenance requirements in metabolic crates. Ewes were assigned to three treatment groups according to a triplicate 3×3 Latin Square design for 3 periods of 21 days duration each (9 ewes per treatment, 27 replications). Treatments were TMR (crude protein [CP] = 16.1, total digestible nutrients = 69.1%) moisture levels for 40%, 50%, and 60%. Results No differences were found in body weight gain among all treatment groups (p>0.05). Nitrogen balance including digestible N, retained N, and urinary and fecal N showed no change among the treatment groups (p>0.05). Fresh water intake was the lower in 50% TMR moisture group than in the other groups (p<0.05). Other than ether extract which was higher in 60% TMR moisture group (p<0.05) the differences among nutrient digestibilities including CP, organic matter, dry matter, neutral detergent fiber, acid detergent fiber, and non-fiber carbohydrate were not significant (p>0.05). No significant difference was observed for serum protein, blood urea nitrogen, glucose, and triglyceride among the treatment groups (p>0.05). Wool and blood cortisol were not different among the treatment groups (p>0.05). Blood hematology including red blood cell, white blood cells, hemoglobin, hematocrit, basophils, and eosinophils were not different among the treatment groups (p>0.05). Conclusion It is concluded that TMR moisture at 40%, 50%, and 60% had no effects on N balance parameters, and nutrient digestibilities except for the ether extract under hot and humid conditions. Additionally there were no effects on stress conditions include wool cortisol, as well as blood cortisol levels of ewes.
Nicotine Increases Impulsivity and Decreases Willingness to Exert Cognitive Effort despite Improving Attention in “Slacker” Rats: Insights into Cholinergic Regulation of Cost/Benefit Decision Making

Successful decision making in our daily lives requires weighing an option’s costs against its associated benefits. The neuromodulator acetylcholine underlies both the etiology and treatment of a number of illnesses in which decision making is perturbed, including Alzheimer’s disease, attention-deficit/hyperactivity disorder, and schizophrenia. Nicotine acts on the cholinergic system and has been touted as a cognitive enhancer by both smokers and some researchers for its attention-boosting effects; however, it is unclear whether treatments that have a beneficial effect on attention would also have a beneficial effect on decision making. Here we utilize the rodent Cognitive Effort Task (rCET), wherein animals can choose to allocate greater visuospatial attention for a greater reward, to examine cholinergic contributions to both attentional performance and choice based on attentional demand. Following the establishment of baseline behavior, four drug challenges were administered: nicotine, mecamylamine, scopolamine, and oxotremorine (saline plus three doses for each). As per previous rCET studies, animals were divided by their baseline preferences, with “worker” rats choosing high-effort/high-reward options more than their “slacker” counterparts. Nicotine caused slackers to choose even fewer high-effort trials than at baseline, but had no effect on workers’ choice. Despite slackers’ decreased willingness to expend effort, nicotine improved their attentional performance on the task. Nicotine also increased measures of motor impulsivity in all animals. In contrast, scopolamine decreased animals’ choice of high-effort trials, especially for workers, while oxotremorine decreased motor impulsivity for all animals. In sum, the cholinergic system appears to contribute to decision making, and in part these contributions can be understood as a function of individual differences. While nicotine has been considered as a cognitive enhancer, these data suggest that its modest benefits to attention may be coupled with impulsiveness and decreased willingness to work hard, especially in individuals who are particularly sensitive to effort costs (i.e. slackers).
Expression of neuropeptide hormone receptors in human adrenal tumors and cell lines: Antiproliferative effects of peptide analogues

Peptide analogues targeting various neuropeptide receptors have been used effectively in cancer therapy. A hallmark of adrenocortical tumor formation is the aberrant expression of peptide receptors relating to uncontrolled cell proliferation and hormone overproduction. Our microarray results have also demonstrated a differential expression of neuropeptide hormone receptors in tumor subtypes of human pheochromocytoma. In light of these findings, we performed a comprehensive analysis of relevant receptors in both human adrenomedullary and adrenocortical tumors and tested the antiproliferative effects of peptide analogues targeting these receptors. Specifically, we examined the receptor expression of somatostatin-type-2 receptor, growth hormone-releasing hormone (GHRH) receptor or GHRH receptor splice variant-1 (SV-1) and luteinizing hormone-releasing hormone (LHRH) receptor at the mRNA and protein levels in normal human adrenal tissues, adrenocortical and adrenomedullary tumors, and cell lines. Cytotoxic derivatives of somatostatin AN-238 and, to a lesser extent, AN-162, reduced cell numbers of uninduced and NGF-induced adrenomedullary pheochromocytoma cells and adrenocortical cancer cells. Both the splice variant of GHRH receptor SV-1 and the LHRH receptor were also expressed in adrenocortical cancer cell lines but not in the pheochromocytoma cell line. The GHRH receptor antagonist MZ-4–71 and LHRH antagonist Cetrorelix both significantly reduced cell growth in the adrenocortical cancer cell line. In conclusion, the expression of receptors for somatostatin, GHRH, and LHRH in the normal human adrenal and in adrenal tumors, combined with the growth-inhibitory effects of the antitumor peptide analogues, may make possible improved treatment approaches to adrenal tumors.
Has this bug been reported?

Bug reporting is essentially an uncoordinated process. The same bugs could be repeatedly reported because users or testers are unaware of previously reported bugs. As a result, extra time could be spent on bug triaging and fixing. In order to reduce redundant effort, it is important to provide bug reporters with the ability to search for previously reported bugs. The search functions provided by the existing bug tracking systems are using relatively simple ranking functions, which often produce unsatisfactory results. In this paper, we adopt Ranking SVM, a Learning to Rank technique to construct a ranking model for effective bug report search. We also propose to use the knowledge of Wikipedia to discover the semantic relations among words and documents. Given a user query, the constructed ranking model can search for relevant bug reports in a bug tracking system. Unlike related works on duplicate bug report detection, our approach retrieves existing bug reports based on short user queries, before the complete bug report is submitted. We perform evaluations on more than 16,340 Eclipse and Mozilla bug reports. The evaluation results show that the proposed approach can achieve better search results than the existing search functions provided by Bugzilla and Lucene. We believe our work can help users and testers locate potential relevant bug reports more precisely.
Attention to the Scale: Deep Multi-Scale Salient Object Detection

Salient object detection has been greatly boosted thanks to the deep convolutional neural networks (CNN), especially fully convolutional neural networks (FCN). Nowadays, it is possible to train an end-to-end deep model for salient object detection. However, the diverse scales of salient objects still pose major challenges for these state-of-the-art methods. In this paper, we investigate how different scales of context information affect the performance of salient object detection by building our saliency prediction model on a pyramid spatial pooling network. An attention-to-scale model is trained to measure the importance of saliency features at different scales, and a saliency fusion stage is utilized to extract complementary information from different scales. The proposed model is trained in an end-to-end manner. Extensive experimental results on eight benchmark datasets demonstrate the superior performance of our proposed method compared with existing state-of-the-art methods.
Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences

In epithelial and muscle cells, intermediate filaments (IFs) are important for resistance to mechanical stress. The aim of this study was to elucidate whether IFs are also important for providing resistance to mechanical stress in the Müller cells of the retina and whether this has any pathophysiological consequences. We used mice deficient in IF proteins glial fibrillary acidic protein and/or vimentin (GFAP–/–, Vim–/– and GFAP–/– Vim–/–), and stress on the retina was applied by excision of the eyes immediately post mortem (compared with in situ fixation) or by inducing a neovascular response to oxygen-induced retinopathy (OIR). The structure of unchallenged retinas was normal, but mechanical stress caused local separation of the inner limiting membrane (ILM) and adjacent tissue from the rest of the retina in GFAP–/– Vim–/– mice and, to a lesser extent, in Vim–/– mice. This detachment occurred within the endfeet of Müller cells, structures normally rich in IFs but IF-free in GFAP–/– Vim–/– mice. Hypoxia-induced neovascularization was comparable in all groups of mice with respect to the retinal surface area occupied by new vessels. However, the vessels traversed the ILM and penetrated the vitreous body less frequently than in wild-type retinas (31-55% in Vim–/–, 66-79% in GFAP–/– Vim–/–). We conclude that IFs are important for maintaining the mechanical integrity of Müller-cell endfeet and the inner retinal layers under a mechanical challenge. Furthermore, the absence of IFs in Müller cells leads to an abnormal response of the vascular system to ischemia, specifically decreased ability of newly formed blood vessels to traverse the ILM.
Enhancement of NK Cell Cytotoxicity Induced by Long-Term Living in Negatively Charged-Particle Dominant Indoor Air-Conditions

Investigation of house conditions that promote health revealed that negatively charged-particle dominant indoor air-conditions (NCPDIAC) induced immune stimulation. Negatively charged air-conditions were established using a fine charcoal powder on walls and ceilings and utilizing forced negatively charged particles (approximate diameter: 20 nm) dominant in indoor air-conditions created by applying an electric voltage (72 V) between the backside of the walls and the ground. We reported previously that these conditions induced a slight and significant increase of interleukin-2 during a 2.5-h stay and an increase of NK cell cytotoxicity when examining human subjects after a two-week night stay under these conditions. In the present study, seven healthy volunteers had a device installed to create NCPDIAC in the living or sleeping rooms of their own homes. Every three months the volunteers then turned the NCPDIAC device on or off. A total of 16 ON and 13 OFF trials were conducted and their biological effects were analyzed. NK activity increased during ON trials and decreased during OFF trials, although no other adverse effects were found. In addition, there were slight increases of epidermal growth factor (EGF) during ON trials. Furthermore, a comparison of the cytokine status between ON and OFF trials showed that basic immune status was stimulated slightly during ON trials under NCPIADC. Our overall findings indicate that the NCPDIAC device caused activation of NK activity and stimulated immune status, particularly only on NK activity, and therefore could be set in the home or office buildings.
A chronosequence approach to estimate the regional soil organic carbon stock on moraines of two glacial fore-fields in SE-Iceland

ABSTRACT SOC has received increased attention over the last decades because of its role as an option to mitigate the effects of increased anthropogenic greenhouse gas emissions. In Iceland, the loss of vegetation and soil due to land-use and natural processes has left large areas as barren deserts. Land restoration actions have the primary goals to prevent land degradation and restore lost ecosystems but the ancillary benefits of SOC accumulation with regard to COP 21 are obvious. Natural vegetation succession is active in areas being exposed by glacial recession since the end of the Little Ice Age in ∼1890. Here, we attempt to estimate the current regional SOC stock on undisturbed moraines in front of two glaciers in SE-Iceland, using surface age, soil properties and vegetation cover data. RapidEye images were used to estimate the surface area of two vegetation classes with <50% and >50% cover. Regional SOC stock was calculated using soil data and the sum of the area of each cover class for each time-zone. The rates of SOC accretion reached the maximum values of 0.004−0.009 kg C m−2 yr−1. The regional SOC stock for the two glacier fore-fields was estimated at 1605 Mg C (0−10 cm) for Skaftafellsjökull (396 ha) and 1106 Mg C (0−5 cm) for Breiðamerkurjökull (632 ha). The current annual increase in the moraine SOC stocks was estimated at 20.7 Mg C yr−1 for Skaftafellsjökull and 19.7 Mg C yr−1 for Breiðamerkurjökull.
Left atrial volume quantification using cardiac MRI in atrial fibrillation: comparison of the Simpson's method with biplane area-length, ellipse, and three-dimensional methods.

PURPOSE Left atrial volume is an important predictor of future arrhythmias, and it can be assessed by several different methods. Simpson's method is well accepted as a reference standard, although no standardization exists for cardiac magnetic resonance (CMR). We aimed to compare the estimations of left atrial volumes obtained by the Simpson's method with three other methods. MATERIALS AND METHODS Eighty-one consecutive patients referred for CMR imaging between February 2007 and May 2010 were included in the study (47 males; mean age, 59.4±11.5 years; body mass index, 26.3±3.7 kg/m(2)). Left atrial volume measurements were performed using the Simpson's, biplane area-length, ellipse, and three-dimensional methods. Results were correlated using a Bland-Altman plot and linear regression models and compared by two-tailed paired-sample t tests. Reader variability was also calculated. RESULTS Left atrial volume measurements using the biplane area-length technique showed the best correlation with Simpson's method (r=0.92; P < 0.001). Quantification values using the ellipse and three-dimensional methods were significantly different than values obtained using the Simpson's method (P < 0.05, for both). All methods showed excellent observer reliability (intra-class correlation coefficient >0.99). CONCLUSION The biplane area-length method can be used for left atrial volume measurement when the Simpson's method cannot be performed. If these two methods are not feasible, then all methods are highly reproducible and can be used, but should not be used interchangeably for follow-up studies.
Automatic bilingual lexicon acquisition using random indexing of parallel corpora

This paper presents a very simple and effective approach to using parallel corpora for automatic bilingual lexicon acquisition. The approach, which uses the Random Indexing vector space methodology, is based on finding correlations between terms based on their distributional characteristics. The approach requires a minimum of preprocessing and linguistic knowledge, and is efficient, fast and scalable. In this paper, we explain how our approach differs from traditional cooccurrence-based word alignment algorithms, and we demonstrate how to extract bilingual lexica using the Random Indexing approach applied to aligned parallel data. The acquired lexica are evaluated by comparing them to manually compiled gold standards, and we report overlap of around 60%. We also discuss methodological problems with evaluating lexical resources of this kind.
Toxicity Of Indole-3-acetic Acid Combined With Horseradish Peroxidase On Staphylococcus Aureus

We investigated the action of indole-3-acetic acid (IAA) combined with horseradish peroxidase (HRP) on Staphylococcus aureus death. S. aureus is a pathogen microorganism capable of causing several diseases. S. aureus was incubated for 1.5, 3.0, and 6.0 h in the absence (control) and presence of IAA, HRP or both IAA/HRP and was then examined: Colony formations, membrane integrity and membrane depolarization. Hydrogen peroxide (H2O2) and superoxide anion (O2.) production by IAA/HRP and their roles in S. aureus death were also evaluated. The gathered data were tested by ANOVA and Tukey test, using P-.
On sampling with Markov chains

In this paper, we apply some recent eigenvalue bounds based on heat kernel estimates to provide polynomial bounds on Markov chain approaches to a number of sampling problems. In particular, for the space S of m by n contingency tables (which are arrays of non-negative integers having fixed row and column sums), we give the first bounds on the mixing time for the natural walk on S which is polynomial in m, n and the row and column sums, provided the minimum row and column sums are large enough.
The Impact of Summer Programs on the English Language Scores of Migrant Children

ABSTRACT Children of Migrant and Seasonal Farmworkers (MSFWs) in the United States face educational challenges from language barriers and disjointed schooling due to migration and other factors. This quasi-experimental pretest/posttest study investigated whether summer Migrant Education Programs (MEP) could help prevent summer learning loss in English proficiency. Kindergarten through fourth-grade Latinx migrant students who attended MEP summer programs in Northwest Ohio were assessed with the IDEA Proficiency Test (n = 246) and the i-Ready Diagnostic (n = 92). Paired samples t-tests analyzed pre/post differences, and ANOVA and ANCOVA analyzed differences in gains between school locations and grade levels. On average, migrant students attending the MEP experienced significant gains in their English speaking and language art scores over the summer. These gains did not differ significantly by grade; however, they did differ by school. Results suggest that these programs may prevent learning loss, even resulting in summer learning gains for some children of MSFWs.
GANs Trained by a Two Time-Scale Update Rule Converge to a Local Nash Equilibrium

Generative Adversarial Networks (GANs) excel at creating realistic images with complex models for which maximum likelihood is infeasible. However, the convergence of GAN training has still not been proved. We propose a two time-scale update rule (TTUR) for training GANs with stochastic gradient descent on arbitrary GAN loss functions. TTUR has an individual learning rate for both the discriminator and the generator. Using the theory of stochastic approximation, we prove that the TTUR converges under mild assumptions to a stationary local Nash equilibrium. The convergence carries over to the popular Adam optimization, for which we prove that it follows the dynamics of a heavy ball with friction and thus prefers flat minima in the objective landscape. For the evaluation of the performance of GANs at image generation, we introduce the "Frechet Inception Distance" (FID) which captures the similarity of generated images to real ones better than the Inception Score. In experiments, TTUR improves learning for DCGANs and Improved Wasserstein GANs (WGAN-GP) outperforming conventional GAN training on CelebA, CIFAR-10, SVHN, LSUN Bedrooms, and the One Billion Word Benchmark.
In vitro effects of 2‐methoxyestradiol‐bis‐sulphamate on the non‐tumorigenic MCF‐12A cell line

A priority in recent anti‐cancer drug development has been attaining better side‐effect profiles for potential compounds. To produce highly specific cancer therapies it is necessary to understand both the effects of the proposed compound on cancer and on normal cells comprising the rest of the human body. Thus in vitro evaluation of these compounds against non‐carcinogenic cell lines is of critical importance. One of the most recent developments in experimental anti‐cancer agents is 2‐methoxyestradiol‐bis‐sulphamate (2ME‐BM), a sulphamoylated derivative of 2‐methoxyestradiol. The aim of this study was to evaluate the in vitro effects of 2ME‐BM on cell proliferation, morphology and mechanisms of cell death in the non‐carcinogenic MCF‐12A breast epithelial cell line. The study revealed changes in proliferative capacity, morphology and cell death induction in response to 2ME‐BM exposure (24 h at 0.4 µM). Microscopy showed decreased cell density and cell death‐associated morphology (increased apoptotic characteristics), a slight increase in acidic intracellular vesicles and insignificant ultra‐structural aberrations. Mitotic indices revealed a G2M‐phase cell cycle block. This was confirmed by flow cytometry, where an increased fraction of abnormal cells and a decrease in cyclin B1 levels were observed. These results evidently demonstrate that the non‐carcinogenic MCF‐12A cell line is less susceptible when compared to 2ME‐BM‐exposed cancer cell lines previously tested. Further in vitro research into the mechanism of this potentially useful compound is warranted. Copyright © 2010 John Wiley & Sons, Ltd.
Self-Insight in Probabilistic Category Learning

ABSTRACT The Weather Prediction (WP) task is one of the most extensively used Probabilistic Category Learning tasks. Although it has been usually treated as an implicit task, its implicit nature has been questioned with focus on the structural knowledge of the acquired information. The goal of the current studies is to test if participants acquire explicit knowledge on the WP task. Experiment 1 addresses this question directly with the help of a subjective measure on self-insight in two groups: an experimental group facing the WP task and a control group with a task lacking predictive structure. Participants in the experimental group produced more explicit reports than the control group, and only on trials with explicit knowledge was their performance higher. Experiment 2 provided further evidence against the implicitness of the task by showing that decreasing stimulus presentation times extends the learning process, but does not result in more implicit processes.