Miracle-dz/UniFAR-FTUs huggingface dataset:
Performing solo Bach: A case study of musical decision-making

This study explores how an expert period instrument musician makes musical decisions, focusing on the distinction between intuitive (Type 1) and deliberate (Type 2) processes as defined by dual-process theories of cognition (Evans, 2008). A case study of the cellist Daniel Yeadon was conducted over 2 years, during which extensive quasi think-aloud and performance data were collected regarding Yeadon’s interpretation of the Suites for Solo Cello by J. S. Bach (BWV 1007–1012). Analysis of this data resulted in the categorization of 134 musical decisions as intuitive, procedural, deliberate, or deliberate HIP (historically informed performance). Procedural decisions were a subset of intuitive, defined as previously deliberate decisions that had become automatic over time. The category of deliberate HIP consisted of decisions that were explained with reference to specific knowledge of historical performance practices. A large proportion of deliberate decision-making was found (65% overall), with deliberate processes dictating the majority of decisions across all performance features except for tone color and ornamentation. Musical decisions discussed in the study demonstrate that performers often manipulate several features of the music simultaneously (making coding and analysis complicated), whether consciously or otherwise. The highest number of musical decisions related to articulation and phrasing, a result that highlights important components of current HIP style. Implications for dual-process theories include the novel category of procedural that demonstrates differences within intuitive (Type 1) processes.
The Prediction of Ego Integrity in Older Persons

This study examined the extent to which the resolution of the Eriksonian final stage-related crisis of ego integrity versus despair is predicted by the resolution of earlier stage-related crises and by non-Eriksonian personality constructs. Subjects were administered an Eriksonian life stage measure called the Inventory of Psychosocial Balance, the Rosenberg Self-Esteem Scale, the Purpose-in-Life Scale, and the Self-Realization Scale. A series of alternative and hierarchically nested regression models was run to assess the direct effects of all preceding Eriksonian life stages and the non-Eriksonian personality measures on the final stage of ego integrity. The results were consistent with Eriksonian theory, which states that personality development is a continuous process in which psychosocial growth during earlier phases of life is a prerequisite for the resolution of later developmental conflicts.
The Test of Memory Malingering (TOMM) in Forensic Psychology

The Test of Memory Malingering (TOMM) is described with particular emphasis directed towards the historical setting within which the TOMM was developed. This includes a review of the criteria for developing a memory malingering test, and the use of the empirically derived decision along with a discussion of the relative merits of empirically based vs. statistically based rules for detecting malingering. Data from a series of five experiments showing the sensitivity of the TOMM to feigned memory impairments, guidelines for interpretation of TOMM scores, and answers to frequently asked questions about the TOMM are provided. Finally, the ability of the TOMM to meet the Daubert guidelines is addressed.
microRNA changes in liver tissue associated with fibrosis progression in patients with hepatitis C

Accumulating evidence indicates that microRNAs play a role in a number of disease processes including the pathogenesis of liver fibrosis in hepatitis C infection. Our goal is to add to the accruing information regarding microRNA deregulation in liver fibrosis to increase our understanding of the underlying mechanisms of pathology and progression.
Quality of Life: From Concept to Future Applications in the Field of Intellectual Disabilities

The authors consider conclusions reached with respect to quality of life (QoL); these are examined in terms of both the past and present developments and within the context of three major areas. These three are (1) application of QoL through support and intervention; (2) the application to family QoL and the development of a working model; and (3) application of QoL for policy and evaluation. These conclusions are examined in relation to implications for public policy in terms of support and intervention, measurement and evaluation, with particular focus on a greater understanding and acceptance of the implications and structure involved in the QoL model and the importance of family QoL. The authors maintain that this should entail the development of applications that are empirically based and, wherever possible, take into account the complexity of mediator variables.
Abandoned Women and Spaces of the Exception

I consider two cases of legal abandonment in Vancouver—of murdered sex workers and live-in caregivers on temporary work visas—in light of Agamben’s claim that the generalized suspension of the law has become a dominant paradigm of government. I bring to Agamben’s theory a concern to specify both the gendering and racialisation of these processes, and the many geographies that are integral to legal abandonment and the reduction of categories of people to ‘bare life’. The case studies also allow me to explore two limit-concepts that Agamben offers as a means to re-envision political community: the refugee who refuses assimilation in the nation-state, and the human so degraded as to exist beyond conventional humanist ethics of respect, dignity and responsibility.
The Level of DAL80 Expression Down-Regulates GATA Factor-Mediated Transcription inSaccharomyces cerevisiae

ABSTRACT Nitrogen-catabolic gene expression in Saccharomyces cerevisiae is regulated by the action of four GATA family transcription factors: Gln3p and Gat1p/Nil1p are transcriptional activators, and Dal80 and Deh1p/Gzf3p are repressors. In addition to the GATA sequences situated upstream of all nitrogen catabolite repression-sensitive genes that encode enzyme and transport proteins, the promoters of the GAT1, DAL80, andDEH1 genes all contain multiple GATA sequences as well. These GATA sequences are the binding sites of the GATA family transcription factors and are hypothesized to mediate their autogenous and cross regulation. Here we show, using DAL80 fused to the carbon-regulated GAL1,10 or copper-regulated CUP1 promoter, that GAT1expression is inversely regulated by the level of DAL80expression, i.e., as DAL80 expression increases,GAT1 expression decreases. The amount of DAL80expression also dictates the level at which DAL3, a gene activated almost exclusively by Gln3p, is transcribed. Gat1p was found to partially substitute for Gln3p in transcription. These data support the contention that regulation of GATA-factor gene expression is tightly and dynamically coupled. Finally, we suggest that the complicated regulatory circuit in which the GATA family transcription factors participate is probably most beneficial as cells make the transition from excess to limited nitrogen availability.
Safety and Tolerability of Lamotrigine: Results From 12 Placebo-Controlled Clinical Trials and Clinical Implications

The mechanism of action of lamotrigine depends on voltage-sensitive sodium channels by which the neuronal membrane is stabilized and the release of excitatory neurotransmitters, such as glutamate and aspartate, is inhibited. Lamotrigine is indicated for maintenance treatment of bipolar I disorder to delay the time to the occurrence of mood episodes for those treated for acute mood episodes with standard therapy. There are significant gaps between clinical practices and research settings; data from controlled clinical trials of lamotrigine provide essential information about safety in bipolar populations because they result from large samples of patients with a specific disease and include comparisons with placebo or other comparators with randomized designs. In addition, lamotrigine's safety and tolerability data differ slightly in relation to disease entities, age ranges of the patients taking lamotrigine, and treatment conditions. For example, the incidence of serious rashes, including Stevens-Johnson syndrome, is approximately 0.8% (8/1000) in pediatric patients (2-16 years of age) receiving lamotrigine as adjunctive therapy for epilepsy and 0.3% (3/1000) in adults on adjunctive therapy for epilepsy. In clinical trials of bipolar and other mood disorders, the rate of serious rash was 0.08% (0.8/1000) in adult patients receiving lamotrigine as initial monotherapy and 0.13% (1.3/1000) in adult patients receiving lamotrigine as adjunctive therapy.Hence, in this study, we focus on the data regarding the safety and tolerability of lamotrigine in the treatment of bipolar disorder gathered from 12 placebo-controlled trials, regardless of publication status, that were sponsored by GlaxoSmithKline. We also inform clinicians of practical issues in safety and tolerability in the use of lamotrigine in the treatment of bipolar disorders.
In the Pages of Ms.: Sex Role Portrayals of Women in Advertising

Abstract The stated advertising policy of Ms. magazine precludes the acceptance of advertisements for products that are “harmful” or advertisements that are insulting to women. This study employs manifest and latent content analysis to assess the extent to which Ms. advertising, over the first 15 full years of its publication has carried out this policy. The findings suggest that a substantial proportion of Ms. advertising promotes products generally considered “harmful. ” Also, while the portrayal of women as subordinate to men or as merely decorative has decreased over time, Ms. advertising has increasingly portrayed women as alluring sex objects. Possible reasons for the trends revealed here are discussed.
Effects of Structural Characteristics of Stem Format of Multiple-Choice Items on Item Difficulty and Discrimination 1

The effects of stem orientation (positively stated stem or negatively stated) and completeness (closed or complete stem and incomplete stem) of multiple-choice items on difficulty and discrimination, were studied experimentally employing 142 senior students in education (82 women and 60 men). Incomplete versus complete stems increased item difficulty but had no effect on discrimination. Stem orientation had no effect on either difficulty or discrimination. The implications of the results are discussed.
Investigating the use of social networking sites and their implications for HIV/Aids communication amongst Rhodes University students

Abstract The rise and dominance of social networking sites has generated increasing interest amongst scholars, mainly to understand their nature and the activities supported by these social sites. Studies conducted on social networking sites have generated information on the potential of such sites in boosting revenue-generating businesses, with limited research on how online sites can be used to address the social challenges faced by societies today. This article maintains that online social sites, in particular HIV/Aids-related sites, can possibly be used for HIV/Aids communication. The article therefore presents and reflects on the use of social networking sites amongst Rhodes students and the implications for HIV/Aids communication. The concept ‘use’ in this article is discussed under three sub-topics: (1) extent of social network site use; (2) topics or issues discussed on social sites focusing on HIV/Aids issues; and (3) the advantages and challenges of using social sites to communicate about issues such as HIV and Aids. Using both quantitative and qualitative approaches to the research design and methodology, the study found that social networking sites have become part of the youth's everyday activities, with social sites focusing on HIV/Aids-related issues being used as platforms for learning about the disease, sharing personal experiences and even finding encouragement from peers facing similar challenges. Drug abuse and sexual debut are amongst the topics discussed on HIV/Aids sites. The study also reveals that the effectiveness of social sites in communicating about HIV/Aids can be downplayed by issues of privacy, artificiality and the nature of relationships within networks.
A prospective comparative study to assess the accuracy of MRI versus HSG in tubouterine causes of female infertility

Objective: To evaluate the role of magnetic resonance imaging versus hysterosalpingography during investigating infertile women due to uterotubal causes of infertility Setting: kasr EL-Aini Hospital Materials and methods: All infertile women were subjected to both hysterosalpingography and MRI. Laparoscopy was performed to confirm different findings, being considered the gold standard for diagnosis. Results: MRI was superior to HSG in diagnosing uterine anomalies (accuracy 100% vs. 96%), but failed to diagnose any case of intrauterine adhesions or peritubal adhesions. Conclusion: In infertile women with suspected uterine anomalies, magnetic resonance imaging is the study of choice because of its high accuracy and detailed elaboration of uterovaginal anatomy. Laparoscopy and hysteroscopy are reserved for women in whom interventional therapy is likely to be undertaken.
Bortezomib (Velcade™) in the Treatment of Multiple Myeloma

The introduction of bortezomib, a novel first-in-class proteasome inhibitor, has been a major break through in the treatment of multiple myeloma. It is currently approved for the treatment of myeloma in the relapsed setting post transplant or as a second line treatment in patients unsuitable for transplantation. In pre-clinical studies bortezomib showed a number of different anti-myeloma effects including disruption of the cell cycle and induction of apoptosis, alteration of the bone marrow microenvironment and inhibition of nuclear factor kappa B (NFκB). Due to its novel mechanism of action, bortezomib has been shown to induce responses in previously refractory patients (including those with poor risk cytogenetics), and results in an increased progression free and overall survival in relapsed patients when compared with dexamethasone treatment alone. It is well tolerated and can be administered in the outpatient setting with manageable toxicities. Peripheral neuropathy is the most common dose limiting toxicity and thrombocytopenia can generally be managed with platelet transfusions without reducing or omitting doses. Bortezomib shows a synergistic effect in combination with dexamethasone and also sensitises myeloma cells to the effects of other chemotherapeutic agents with major response rates of over 50% being shown in the relapsed setting. Initial data from ongoing trials in front line therapy are encouraging with response rates of 80%–90% when bortezomib is given in combination with other agents and importantly, the ability to mobilize peripheral blood stem cells is not impaired.
Influence of Family Adversity on School-Related Behavioural Problems among Multi-Ethnic High School Students

This study examines the influence of family adversity indicators on school-related behavioural problems among Hawaiian and non-Hawaiian adolescents. Questionnaire data from 2787 students were linked to school information, including grade point average (GPA), absences, suspensions and conduct infractions. Logistic regression analyses were performed. The cumulative effect revealed higher increases in the odds ratios for school-related behavioural problems among non-Hawaiians. Surprisingly, there was no cumulative effect of family adversity among Hawaiian adolescents. Given their high rates of adversity and behavioural problems, any family adversity may significantly impact this group. The family environment must be considered in the prevention and intervention of school-related behavioural problems.
Fatigue behavior of the resinous cement to zirconia bond.

PURPOSE Resinous cements are widely used for luting zirconia restorations. Adhesive failures have occurred at the cement/zirconia interface, rather than at the cement/dentin interface, suggesting that the cement/zirconia bond may lack durability; however, few comprehensive, comparative evaluations of fatigue effects have been reported. The rate of fatigue-induced loss of bond strength may be a more important predictor of long-term success than a single snapshot of bond strength after an arbitrary number of thermocycles. Previous studies have failed to identify trends by investigating bond strengths at several different numbers of cycles. This may result in invalid conclusions about which cements have superior bond strengths. The purpose of this study was to investigate the effects of artificial aging by thermocycling and resinous cement type on bond strengths to zirconia. MATERIALS AND METHODS The effect of the number of thermocycles (0, 1, 10, 100, 1000, and 10,000) on the bond strengths of five resinous cements, two of which were used with and without a primer, and an oxygen-inhibiting gel, was studied. Specimens were randomly assigned to thermocycle number/cement-type test groups. Because zirconia has a very low thermal diffusivity, exceptionally long thermocycle dwell times were used. Cylinders of zirconia were bonded end-to-end. One end of each bonded specimen was insulated, specimens were thermocycled and tested in shear, and bond strengths were calculated and analyzed. RESULTS Two-way ANOVA revealed that the effects of cement type, the number of thermocycles, and their interaction all significantly affected bond strength (p < 0.0001). By 10,000 cycles, most cements had lost at least half of their initial bond strengths, and two cements effectively recorded zero bond strengths. Failure modes were cement specific, but adhesive modes predominated. Fatigue resistance of two cements was greatly improved by use of a primer and an oxygen-inhibiting gel, as recommended by their respective manufacturers. CONCLUSIONS Both the type of resin cement and the number of thermocycles influenced bond strength. Fatigue through thermocycling affected different cement types in different ways. Some materials displayed more rapid loss of bond strength than others. Cements differed in their failure modes.
Exploring Filipino adolescents’ conception of happiness

The current paper aimed to explore the meaning and conception of happiness among selected Filipino adolescents. Ten Filipino college students whose ages range between 16 and 20 were selected through purposive sampling. The study employed qualitative-descriptive research design. Findings showed that happiness is a multifaceted construct that involved the following major themes: satisfaction of wants, absence of worries, expression of positive emotions, motivational drive, and fulfillment of relational needs. Distinct personal characteristics and positive behavioral strategies predictive of happiness were identified as well. Enhancing positive emotions, positive traits and behavioral strategies of individuals from this developmental phase may be a good step to increase their social, psychological and occupational functioning in the form of academic, extra-curricular, co-curricular endeavours.
Is Surgery a Risk Factor for Creutzfeldt-Jakob Disease? Outcome Variation by Control Choice and Exposure Assessments

Objective. To determine whether methodological differences explain divergent results in case-control studies examining surgery as a risk factor for Creutzfeldt-Jakob disease (CJD). Methods. After case-control studies were systematically identified using PubMed, we performed a homogeneity analysis and applied models to effect sizes (odds ratio [OR] with 95% confidence interval [CI]) using 2 parameters: type of control subject used and consistency of data ascertainment. The hospitals and communities were located in Europe, Japan, and Australia. Patients were CJD case subjects and age- and sex-matched control subjects in the hospital or community. Because of the natural history of the disease, CJD subjects are not considered reliable sources of information for these studies. Therefore, individuals who are considered close to the subjects and who have knowledge of their medical history, including spouses and relatives, are necessarily identified as proxy informants for the surgical record of the case subjects. Results. Overall, the effect sizes lacked homogeneity (P<.0001). Three studies that used control subjects from the community revealed a significantly elevated risk of CJD for patients who underwent surgery (OR, 1.82; 95% CI, 1.41-2.35 [P<.0001 ]), whereas 3 investigations that used control subjects from the hospital revealed a significantly reduced risk (OR, 0.69; 95% CI, 0.52-0.90 [P = .0069]). Two studies that used proxy informants to acquire information about case subjects and control subjects (consistent ascertainment) found that the risk of CJD was significantly lower in those subjects who underwent surgery (OR, 0.65; 95% CI, 0.48-0.87 [P = .0043]). Conversely, 4 studies in which proxy informants acted only on behalf of case subjects (inconsistent data ascertainment) found a significant positive association between surgery and CJD (OR, 1.67; 95% CI, 1.32-2.12 [P<.0001 ]). Both models fit the data very well, leaving no remaining variance in effect sizes to explain. Conclusion. Variation in the type of control subjects used and in exposure assessment in case-control studies may partially explain conflicting data regarding the association between surgery and CJD. However, there was almost complete confounding of these 2 parameters, making interpretation more difficult. Planning of future investigations must carefully consider these design elements.
Social capital in action in urban environments: an intersection of theory, research and practice literature

This paper attempts to widen our understanding of the relationship between social capital and the physical environment through an exploration of the intersection of theory, urban design practitioner guidance and empirical research on social capital that considers the built environment as a variable. Theory suggests that social capital in a neighbourhood can grow over time, and that stability of residency and opportunity for social interaction can help to establish the bonds, bridges and networks that build trust and participation. The content analysis of a selection of literature on urban design guidance revealed 12 recurrent attributes that help people to live, work and relax and thus encourage formal or informal interaction and longer‐term residency in the area in which they live, and hence the growth of social capital. As urban design guidance does not use such a term, these attributes were substantiated through reference to empirical research and social capital theory. This exercise gives a better understanding of the specificities of environmental variables, aiding our conceptualization of social capital. If we aspire to assessment tools that incorporate knowledge of predictable relationships between the variables concerned, then it becomes clear there is a long way to go in developing our understanding of the interplay of urban development and social capital.