Miracle-dz/UniFAR-FTUs huggingface dataset:
Distorted-wave calculations of the electron-impact ionization of highly ionized Na-like ions.

We report on distorted-wave calculations of the electron-impact ionization cross sections and rate coefficients for the Na-like ions Ti/sup 11+/, Cr/sup 13+/, Fe/sup 15+/, and Ni/sup 17+/. The cross sections for direct ionization out of the 3s, 2p, and 2s subshells were determined using the configuration-average, distorted-wave approximation. In addition, excitation-autoionization contributions originating from inner-shell excitations of the type 2s/sup 2/2p/sup 6/3s. -->. 2s/sup 2/2p/sup 5/3snl (n = 3,4,5) and 2s/sup 2/2p/sup 6/3s . -->. 2s2p/sup 6/3snl (n = 3,4) were calculated by employing the distorted-wave approximation and configuration-interaction, bound-state wave functions. Near threshold, the total-ionization cross sections in all four ions are enhanced by approximately a factor of 5 through excitation autoionization. These excitation-autoionization contributions are large, even though they have been substantially reduced by radiative decay to the bound states of the initial ion. Furthermore, although electron correlation has a minimal effect on the excitation cross sections, the magnitude of the branching ratios for autoionization is quite sensitive to configuration interaction in the autoionizing levels. This is especially true for the 2p. -->. 3d excitations, where configuration interaction between 2p/sup 5/3s3d and 2p/sup 5/3p/sup 2/ can increase the magnitude of the autoionizing rates for levels within the 2p/sup 5/3s3d configuration by as much asmore » three orders of magnitude. Thus, for example, in the case of the 2p. -->. 3d excitation in Ni/sup 17+/, correlation increases the overall branching ratio for autoionization from 0.27 to 0.53. « less
Pleiotropic Modulation of Carbon and Nitrogen Metabolism in Arabidopsis Plants Overexpressing the NAD kinase2 Gene1[W]

Nicotinamide nucleotides (NAD and NADP) are important cofactors in many metabolic processes in living organisms. In this study, we analyzed transgenic Arabidopsis (Arabidopsis thaliana) plants that overexpress NAD kinase2 (NADK2), an enzyme that catalyzes the synthesis of NADP from NAD in chloroplasts, to investigate the impacts of altering NADP level on plant metabolism. Metabolite profiling revealed that NADP(H) concentrations were proportional to NADK activity in NADK2 overexpressors and in the nadk2 mutant. Several metabolites associated with the Calvin cycle were also higher in the overexpressors, accompanied by an increase in overall Rubisco activity. Furthermore, enhanced NADP(H) production due to NADK2 overexpression increased nitrogen assimilation. Glutamine and glutamate concentrations, as well as some other amino acids, were higher in the overexpressors. These results indicate that overexpression of NADK2 either directly or indirectly stimulates carbon and nitrogen assimilation in Arabidopsis under restricted conditions. Importantly, since neither up-regulation nor down-regulation of NADK2 activity affected the sum amount of NAD and NADP or the redox state, the absolute level of NADP and/or the NADP/NAD ratio likely plays a key role in regulating plant metabolism.
Rain Retrieval from TMI Brightness Temperature Measurements Using a TRMM PR-Based Database

This study focuses on improving the retrieval of rain from measured microwave brightness temperatures and the capability of the retrieved field to represent the mesoscale structure of a small intense hurricane. For this study, a database is constructed from collocated Tropical Rainfall Measuring Mission (TRMM) precipitation radar (PR) and the TRMM Microwave Imager (TMI) data resulting in about 50 000 brightness temperature vectors associated with their corresponding rain-rate profiles. The database is then divided in two: a retrieval database of about 35 000 rain profiles and a test database of about 25 000 rain profiles. Although in principle this approach is used to build a database over both land and ocean, the results presented here are only given for ocean surfaces, for which the conditions for the retrieval are optimal. An algorithm is built using the retrieval database. This algorithm is then used on the test database, and results show that the error can be constrained to reasonable levels for most of the observed rain ranges. The relative error is nonetheless sensitive to the rain rate, with maximum errors at the low and high ends of the rain intensities (60% and 30%, respectively) and a minimum error between 1 and 7 mm h 1 . The retrieval method is optimized to exhibit a low total bias for climatological purposes and thus shows a high standard deviation on point-to-point comparisons. The algorithm is applied to the case of Hurricane Bret (1999). The retrieved rain field is analyzed in terms of structure and intensity and is then compared with the TRMM PR original rain field. The results show that the mesoscale structures are indeed well reproduced even if the retrieved rain misses the highest peaks of precipitation. Nevertheless, the mesoscale asymmetries are well reproduced and the maximum rain is found in the correct quadrant. Once again, the total bias is low, which allows for future calculation of the heat sources/sinks associated with precipitation production and evaporation.
Reaction Time Variability in Children With ADHD Symptoms and/or Dyslexia

Reaction time (RT) variability on a Stop Signal task was examined among children with attention deficit hyperactivity disorder (ADHD) symptoms and/or dyslexia in comparison to typically developing (TD) controls. Children's go-trial RTs were analyzed using a novel ex-Gaussian method. Children with ADHD symptoms had increased variability in the fast but not the slow portions of their RT distributions compared to those without ADHD symptoms. The RT distributions of children with dyslexia were similar to those of TD-controls. It is argued that variability in responding may be underpinned by impairments in response preparation or timing during Stop Signal tasks.
Effectiveness of interventions to prevent delirium in hospitalized patients: a systematic review.

OBJECTIVE To determine the effectiveness of interventions to prevent delirium in hospitalized patients. DATA SOURCES Two databases, MEDLINE and CINAHL, were searched for relevant articles published from January 1966 to May 1995 and from January 1982 to May 1995 respectively. The bibliographies of identified articles were searched for additional references. STUDY SELECTION Ten articles met the following three inclusion criteria: (a) original research article, (b) published in English or French and (c) controlled trial (nonrandomized or randomized) of an intervention to prevent delirium in hospitalized patients. The validity of the studies was independently assessed according to the criteria for intervention studies proposed by the Evidence-Based medicine Working Group. DATA EXTRACTION Information about study design, patient population, sample size, diagnostic criteria, interventions and results was systematically abstracted from each report. Absolute risk reduction (ARR) for delirium was calculated for each study. DATA SYNTHESIS Eight trials involved surgical patients and two involved elderly medical patients; most of the studies had serious methodological limitations. Among the surgical patients the ARRs ranged from -13% to 81% and were not related to the type or timing of the intervention, or to the personnel involved. Among the elderly medical patients the ARRs ranged from -3% to 3%. CONCLUSION Interventions to prevent delirium among surgical patients may be modestly effective, but further trials are necessary.
Spectroscopic and Voltammetric Study on the Binding of Aluminium(III) to DNA

Cyclic voltammetry (CV) and ultraviolet (UV) spectroscopy were used, for the first time, to study the interaction between aluminium(III) and calf thymus DNA under neutral pH conditions. Thus obtained data confirmed the existence of a relatively strong interaction between Al(III) and DNA. The binding site for aluminium(III) on DNA chains is not the bases, but the phosphate groups on the DNA backbones, the same as that for [Co(phen)3]^3+/2+ that binds non-specifically and electrostatically to the deoxyribose phosphate backbone of DNA. When coexisting, Al(III) binds more favorably to DNA than [Co(phen)_3]^3+/2+, which implies the relatively strong binding of Al(III) to the phosphate backbone of DNA under neutral pH conditions. The nature of the binding of Al(III) to DNA is also discussed.
A PAS domain-containing regulator controls flagella-flagella interactions in Campylobacter jejuni

The bipolar flagella of the foodborne bacterial pathogen Campylobacter jejuni confer motility, which is essential for virulence. The flagella of C. jejuni are post-translationally modified, but how this process is controlled is not well understood. In this work, we have identified a novel PAS-domain containing regulatory system, which modulates flagella-flagella interactions in C. jejuni. Inactivation of the cj1387c gene, encoding a YheO-like PAS6 domain linked to a helix-turn-helix domain, resulted in the generation of a tightly associated “cell-train” morphotype, where up to four cells were connected by their flagella. The morphotype was fully motile, resistant to vortexing, accompanied by increased autoagglutination, and was not observed in aflagellated cells. The Δcj1387c mutant displayed increased expression of the adjacent Cj1388 protein, which comprises of a single endoribonuclease L-PSP domain. Comparative genomics showed that cj1387c (yheO) orthologs in bacterial genomes are commonly linked to an adjacent cj1388 ortholog, with some bacteria, including C. jejuni, containing another cj1388-like gene (cj0327). Inactivation of the cj1388 and cj0327 genes resulted in decreased autoagglutination in Tween-20-supplemented media. The Δcj1388 and Δcj0327 mutants were also attenuated in a Galleria larvae-based infection model. Finally, substituting the sole cysteine in Cj1388 for serine prevented Cj1388 dimerization in non-reducing conditions, and resulted in decreased autoagglutination in the presence of Tween-20. We hypothesize that Cj1388 and Cj0327 modulate post-translational modification of the flagella through yet unidentified mechanisms, and propose naming Cj1387 the Campylobacter Flagella Interaction Regulator CfiR, and the Cj1388 and Cj0327 protein as CfiP and CfiQ, respectively.
Is postresective intraoperative electrocorticography predictive of seizure outcomes in children?

OBJECT Intraoperative electrocorticography (ECoG) is commonly used to guide the extent of resection, especially in lesion-associated intractable epilepsy. Interictal epileptiform discharges on postresective ECoG (post-ECoG) have been predictive of seizure recurrence in some studies, particularly in adults undergoing medial temporal lobectomy, frontal lesionectomy, or low-grade glioma resection. The predictive value of postresective discharges in pediatric epilepsy surgery has not been extensively studied. METHODS The authors retrospectively examined the charts of all 52 pediatric patients who had undergone surgery with post-ECoG and had more than 1 year of follow-up between October 1, 2003, and October 1, 2009. RESULTS Of the 52 pediatric patients, 37 patients showed residual discharges at the end of their resection and 73% of these patients were seizure free, whereas 15 patients had no residual discharges and 60% of them were seizure-free, which was not significantly different (p = 0.36, chi-square). CONCLUSIONS Electrocorticography-guided surgery was associated with excellent postsurgical outcome. Although this sample size was too small to detect a subtle difference, absence of epileptiform discharges on post-ECoG does not appear to predict seizure freedom in all pediatric patients referred for epilepsy surgery. Future studies with larger study samples would be necessary to confirm this finding and determine whether post-ECoG may be useful in some subsets of pediatric epilepsy surgery candidates.
Post-Weaning Protein Malnutrition in the Rat Produces Short and Long Term Metabolic Impairment, in Contrast to Earlier and Later Periods

Malnutrition during gestation and lactation modifies metabolic strategies and leads to metabolic disease in adult life. Studies in human populations suggest that malnutrition during infancy may also induce long term metabolic disorders. The present study investigated if post-weaning and a late period of development might be sensitive for long term metabolic impairment. Hereto male Wistar rats were malnourished with a low protein diet (6%), during gestation and lactation (MGL), from weaning to 55 days (MPW) or during adulthood from 90 to 120 days (MA). Control rats (C) were fed with a regular diet (23% protein). We determine plasma concentrations of insulin, glucagon, triacylglycerols (TAG), free fatty acids (FFA), and liver glycogen after a Glucose Tolerance Test (GTT). Independent of the age of onset, malnutrition induced low body weight. Early and post-weaning malnutrition produced impaired glucose tolerance and low values of TAG, also in MPW induced low values of insulin and glucagon. At 90 days, after balanced diet rehabilitation, the MGL group showed a similar glucose tolerance test as the controls but display low values of insulin, while the MPW group exhibited high levels of glucose and TAG, and low values of insulin, glucagon, FFA and hepatic glycogen. At 180 days, after balanced rehabilitation only MPW rats showed metabolic alterations. Malnutrition during adult life (MA) did not produce metabolic disturbances. Surprisingly the results uncover the post-weaning stage as a vulnerable period to malnutrition that induces long lasting metabolic alterations and deficiency in pancreatic function.
The diagnosis and treatment of minimal hepatic encephalopathy.

BACKGROUND The subtype of hepatic encephalopathy (HE) called minimal hepatic encephalopathy (MHE) is highly prevalent (22-74%) among patients with liver dysfunction. MEH is defined as HE without grossly evident neurologic abnormalities, but with cognitive deficits that can be revealed by psychometric testing. METHODS This article is based on relevant original publications and reviews in English and German (1970-2011) that were retrieved by a selective key-word-based search in the Medline and PubMed databases. RESULTS Despite its mild manifestations, MHE impairs patients' quality of life and their ability to work. It impairs driving ability and is associated with a higher rate of motor vehicle accidents. Furthermore, patients with MHE fall more often and are more likely to undergo progression to overt HE. The main pathophysiological mechanism of MHE is hyperammonemia leading to astrocyte dysfunction. Psychometric tests are the standard instruments for establishing the diagnosis; further, supportive diagnostic tools include neurophysiological tests and imaging studies. Recent randomized and controlled trials have revealed that treatment with lactulose or rifaximin therapy improves the quality of life of patients with MHE. Rifaximin was also found to improve driving performance in a simulator. A combination of these two drugs prevents the recurrence of episodic HE over a 6-months follow-up period. Moreover, small-scale trials have revealed that some dietary supplements can improve the cognitive deficits of MHE. CONCLUSION Clinical trials have shown that patients with MHE and patients who have had an episode of overt HE in the past can benefit from drug treatment.
Heterochrony and patterns of cranial suture closure in hystricognath rodents

Sutures, joints that allow one bone to articulate with another through intervening fibrous connective tissue, serve as major sites of bone expansion during postnatal craniofacial growth in the vertebrate skull and represent an aspect of cranial ontogeny which may exhibit functional and phylogenetic correlates. Suture evolution among hystricognath rodents, an ecologically diverse group represented here by 26 species, is examined using sequence heterochrony methods, i.e. event pairing and parsimov. Although minor nuances in suture closure sequence exist between species, the overall sequence was found to be conserved both across the hystricognath group and, to an increasing degree, within selected clades. At species level, suture closure pattern exhibited a significant positive correlation with patterns previously reported for hominoids. Patterns for most clades revealed the first sutures to close are those contacting the exoccipital, interparietal, and palatine bones. Heterochronic shifts were found along 19 of 35 branches within the hystricognath phylogeny. The number of shifts per node ranged from one to seven events and, overall, involved 21 of 34 suture sites. The topology generated by parsimony analyses of the event pair matrix yielded only one grouping that was congruent with the evolutionary relationships, compiled from morphological and molecular studies, taken as framework. Sutures contacting the exoccipital displayed the highest levels of most complete closure across all species. Level of suture closure is negatively correlated with cranial length (P < 0.05). Differing life history and locomotory strategies are coupled in part with differing suture closure patterns among several species.
Complex cepstrum-based decomposition of speech for glottal source estimation

Homomorphic analysis is a well-known method for the separation of non-linearly combined signals. More particularly, the use of complex cepstrum for source-tract deconvolution has been discussed in various articles. However there exists no study which proposes a glottal flow estimation methodology based on cepstrum and reports effective results. In this paper, we show that complex cepstrum can be effectively used for glottal flow estimation by separating the causal and anticausal components of a windowed speech signal as done by the Zeros of the Z-Transform (ZZT) decomposition. Based on exactly the same principles presented for ZZT decomposition, windowing should be applied such that the windowed speech signals exhibit mixed-phase characteristics which conform the speech production model that the anticausal component is mainly due to the glottal flow open phase. The advantage of the complex cepstrum-based approach compared to the ZZT decomposition is its much higher speed. Index Terms: Speech Analysis, Homomorphic Processing, Glottal Source Estimation
Efficacy and tolerability of oral versus injectable disease-modifying therapies for multiple sclerosis in clinical practice

Background The advent of oral disease-modifying therapies fundamentally changed the treatment of multiple sclerosis. Nevertheless, impressions of their relative efficacy and tolerability are primarily founded on expert opinion. Objective The purpose of this study was to determine whether oral disease-modifying therapies were better tolerated and/or more effective for controlling multiple sclerosis compared to injectable therapies in clinical practice. Methods Single-center, retrospective cohort study. 480 patients initiated oral (fingolimod, teriflunomide, or dimethyl fumarate) or injectable therapy between March 2013–March 2015 and follow-up data was collected for 5–31 months. Outcomes included on-drug multiple sclerosis activity and drug discontinuation. Cox proportional hazards models were used to control for baseline differences and sensitivity analyses using propensity-weighted matching were performed. Results A higher proportion of teriflunomide-treated patients experienced multiple sclerosis activity compared to those treated with injectable therapies (p = 0.0053) in the adjusted model. Breakthrough multiple sclerosis was equally prevalent among fingolimod and dimethyl fumarate-treated compared to injectable therapy-treated patients. Of patients initiating a disease-modifying therapy, 32–46% discontinued or switched treatments during the study. After controlling for baseline differences, discontinuation rates were comparable across treatment groups. Conclusions In this cohort, oral and injectable disease-modifying therapies were equally well tolerated, but teriflunomide appeared less effective for controlling multiple sclerosis activity than injectable therapies. Further study is needed.
Examining Mechanims of Political Disagreement

This research seeks to develop and test hypotheses about how political disagreement in social networks affects political behavior. We conduct experimental research to test whether subjects’ acquaintances act as independent sources of information, and examine two different models of how such social stimuli may produce effects—either via information seeking, or information shortcuts. These tests are important because prior research is ambiguous on whether causal effects come from networks, and on potential mechanisms of influence. Our results back aspects of both models, but more strongly support the notion of disagreement as a heuristic—subjects primed to consider disagreement before a mock election exhibited a less-orderly information search process; those primed to consider disagreement after the election (but before voting) displayed lower rates of ambivalence, and evidence that such information helped clarify their decisions.
Laboratory Changes Consistent with Feline Infectious Peritonitis in Cats from Multicat Environments

Summary The present study describes the prevalence of haematological and electrophoretic changes consistent with the diagnosis of feline infectious peritonitis (FIP) in cats without FIP living in six multicat environments with different prevalence of FIP and of other diseases. The results allow designing haematological and electrophoretic profiles typical of each group, most likely depending on the management and on the health status of the group rather than on the prevalence of FIP. In fact, many cats from the colonies with open management and frequent outbreaks of infectious diseases other than FIP had one or more haematological and/or electrophoretical changes consistent with FIP, compared with the reference ranges. In the case of non‐specific clinical signs such as fever or neurological signs because of diseases other than FIP, these cats would be erroneously considered as affected by FIP and euthanasized. The use of internal ranges designed on the basis of repeated samplings from non‐symptomatic cats allows avoiding these misinterpretations. Results from cats with symptoms consistent with FIP living in the same colonies were also compared with both the reference ranges and the internal ones: such a comparison demonstrated that the use of internal ranges rarely affected the possibility to correctly diagnose the disease in cats with symptoms suggestive of FIP.
Effect of Ocean Gateway Changes under Greenhouse Warmth

Abstract The role of tectonic Southern Ocean gateway changes in driving Antarctic climate change at the Eocene–Oligocene boundary remains a topic of debate. One approach taken in previous idealized modeling studies of gateway effects has been to alter modern boundary conditions, whereby the Drake Passage becomes closed. Here, the authors follow this approach but vary atmospheric pCO2 over a range of values when comparing gateway configurations. They find a significantly greater sensitivity of Antarctic temperatures to Southern Ocean gateway changes when atmospheric pCO2 is high than when concentrations are low and the ambient climate is cool. In particular, the closure of the Drake Passage (DP) gap is a necessary condition for the existence of ice-free Antarctic conditions at high CO2 concentrations in this coupled climate model. The absence of the Antarctic Circumpolar Current (ACC) is particularly conducive to warm Antarctic conditions at higher CO2 concentrations, which is markedly different from previ.