Miracle-dz/UniFAR-FTUs huggingface dataset:
ENGLISH AND JAPANESE SPEAKERS ’ EMOTION VOCALISATION AND RECOGNITION : A COMPARISON HIGHLIGHTING VOWEL QUALITY

A major question in work on phonetic correlates of emotion is to what extent vocalisation of emotion is due to psychobiological response mechanisms and is therefore quasiuniversal and to what extent it is due to social convention. Cross-cultural research gives an angle in on this question. This paper describes the design and discusses results so far of a study in progress which attempts to shed light on this question and to address some of the very difficult methodological issues in cross-language studies of vocal correlates of emotion. The study compares the cross-cultural decoding accuracy and phonetic correlates of emotion vocalisations encoded by native English and native Japanese speakers. Nonsense utterances and quasi-universally recognised facial expressions of emotions are used. These help deal with translation, ethical problems in data collection, the trade-off between artificiality of data and consistency and the masking of verbal utterances whilst allowing any influence exerted by specific vowel qualities to be highlighted.
ADULT FEMALE DROSOPHILA PSEUDOOBSCURA SURVIVE AND CARRY FERTILE SPERM THROUGH LONG PERIODS IN THE COLD: POPULATIONS ARE UNLIKELY TO SUFFER SUBSTANTIAL BOTTLENECKS IN OVERWINTERING

Abstract To assess whether, while overwintering, natural populations of Drosophila pseudoobscura are likely to experience substantial bottlenecks in their numbers and genotypes, laboratory tests of the cold sensitivities of each stage of the life history and reproduction were undertaken. Three genetically distinctive lineages established from flies caught at high elevation were used for testing in temperatures likely to persist in protected pockets of fermenting deciduous leaf fall in overwintering sites. Sensitivities to cold of each stage in development were measured as frequencies of survival to adulthood following a period in 5°C in a particular stage. The cold sensitivity of adults was measured as the survival in and following cold stays in adulthood. It was found that cold sensitivity decreases as development progresses, but that only adults (females more than males) are able to withstand long periods in the cold. The cold sensitivity of reproductive capacity of males was scored as their success in mating following a two-month cold stay, and of females as the numbers laying fertile eggs following periods of months in the cold. Both males and females maintain reproductive capacity. Of particular significance, however, is that even after six months in the cold females are able to restart production of eggs and these eggs may be fertilized by the sperm of matings prior to their cold stay. Thus, a substantial proportion of overwintering genomes must be those of adult females and those of the sperm carried by females from matings in the previous summer. This simple finding strongly suggests that populations are not likely to suffer substantial bottlenecks while overwintering. Further, it indicates how arrays of genetic variation may be maintained through winters and largely avoid winter selective pressures. Frequent migration between populations is therefore not required to maintain the variation commonly found in populations throughout the species range. Corresponding Editor: H. Allen Orr
Cardiovascular and temperature changes in spinal cord injured rats at rest and during autonomic dysreflexia

In patients with high spinal cord injuries autonomic dysfunction can be dangerous, leading to medical complications such as postural hypotension, autonomic dysreflexia and temperature disturbance. While animal models have been developed to study autonomic dysreflexia, associated temperature changes have not been documented. Our aim here was to use radiotelemetry and infrared thermography in rodents to record the development of cardiovascular and skin temperature changes following complete T4 transection. In adult male Wistar rats (n= 5), responses were assessed prior to spinal cord injury (intact) and for 6 weeks following injury. Statistical analysis by a repeated‐measure ANOVA revealed that following spinal cord injury (SCI), rats exhibited decreased mean arterial pressure (MAP, average decrease of 26 mmHg; P < 0.035) and elevated heart rate (HR, average increase of 65 bpm, P < 0.035) at rest. The basal core body temperature following SCI was also significantly lower than intact levels (−0.9°C; P < 0.0035). Associated with this decreased basal core temperature following SCI was an increased skin temperature of the mid‐tail and hindpaw (+5.6 and +4.0°C, respectively; P < 0.0003) consistent with decreased cutaneous vasoconstrictor tone. Autonomic dysreflexia, in response to a 1 min colorectal distension (25 mmHg), was fully developed by 4 weeks after spinal cord transection, producing increases in MAP greater than 25 mmHg (P < 0.0003). In contrast to the tachycardia seen in intact animals in response to colorectal distension, SCI animals exhibited bradycardia (P < 0.0023). During episodes of autonomic dysreflexia mid‐tail surface temperature decreased (approx. −1.7°C, P < 0.012), consistent with cutaneous vasoconstriction. This is the first study to compare cardiovascular dysfunction with temperature changes following spinal cord transection in rats.
New anticoagulants From bench to bedside

Heparins and vitamin K antagonists have been the cornerstones of anticoagulation therapy for several decades. Although they are very effective at inhibiting the coagulation process, they have several practical limitations. This was a challenge for the development of therapies that will overcome these drawbacks while matching the efficacy of the two classes of anticoagulants. Advances were achieved in the development of safer, convenient, more specific treatments, which should provide predictable anticoagulant responses and substantially improve the prevention and management of thromboembolic disorders. In the search for new agents matching the ideal anticoagulant profile, different steps in the coagulation cascade have been targeted, including direct thrombin inhibition, and inhibition of factor Xa, factor IXa, the factor Vlla-tissue factor complex and the factor Va-factor Vllla complex. The most advanced clinical development has been achieved with direct factor Xaand factor IIa-inhibitors which may replace conventional anticoagulants for long-term prevention and treatment of venous and arterial thromboembolic complications. Schlüsselwörter Antikoagulanzien, Faktor-Xa-Inhibitoren, Faktor-IIa-Inhibitoren, Vitamin-K-Antagonisten
Explicit and implicit neural mechanisms for processing of social information from facial expressions: A functional magnetic resonance imaging study

The processing of changing nonverbal social signals such as facial expressions is poorly understood, and it is unknown if different pathways are activated during effortful (explicit), compared to implicit, processing of facial expressions. Thus we used fMRI to determine which brain areas subserve processing of high‐valence expressions and if distinct brain areas are activated when facial expressions are processed explicitly or implicitly. Nine healthy volunteers were scanned (1.5T GE Signa with ANMR, TE/TR 40/3,000 ms) during two similar experiments in which blocks of mixed happy and angry facial expressions (“on” condition) were alternated with blocks of neutral faces (control “off” condition). Experiment 1 examined explicit processing of expressions by requiring subjects to attend to, and judge, facial expression. Experiment 2 examined implicit processing of expressions by requiring subjects to attend to, and judge, facial gender, which was counterbalanced in both experimental conditions. Processing of facial expressions significantly increased regional blood oxygenation level‐dependent (BOLD) activity in fusiform and middle temporal gyri, hippocampus, amygdalohippocampal junction, and pulvinar nucleus. Explicit processing evoked significantly more activity in temporal lobe cortex than implicit processing, whereas implicit processing evoked significantly greater activity in amygdala region. Mixed high‐valence facial expressions are processed within temporal lobe visual cortex, thalamus, and amygdalohippocampal complex. Also, neural substrates for explicit and implicit processing of facial expressions are dissociable: explicit processing activates temporal lobe cortex, whereas implicit processing activates amygdala region. Our findings confirm a neuroanatomical dissociation between conscious and unconscious processing of emotional information. Hum. Brain Mapping 9:93–105, 2000. © 2000 Wiley‐Liss, Inc.
A Randomized Controlled Trial to Compare the Efficacy of Bisphosphonates in the Management of Painful Bone Metastasis

Introduction: The prospective interventional single-institution randomized control study was carried out to compare the pain relieving efficacy among different bisphosphonates at the cost of incidence of skeletal-related events (SRE). Materials and Methods: During June 2008 and May 2011, 256 patients with painful bone metastasis in solid tumors with a pain score of at least 5 were randomized into three arms: zoledronic acid (4 mg, i.v.), ibandronate (6 mg, i.v.) and pamidronate (90 mg, i.v.). Radiation was given to all patients, either 800 cGy single fraction or 20 Gy in five fractions. The ANOVA test was used for analysis. The Pearson test was used to correlate pain scores with proportions of responders as statistical estimation of pain relief. Results: With a mean baseline pain score of 6.5 ± 1.2, there was no difference in pain scores among the three treatment arms, assessed at 3 months and at the end of the study. However, the pain scores at 6 months were statistically reduced in zoledronic acid-receiving patients (1.5 ± 0.4) unlike the scores in patients receiving ibandronate (3.1 ± 0.5) and pamidronate (2.3 ± 0.4), with a P-value of 0.024. The response was statistically significant at 6 months (0.039) and at the end of the study (0.023), in favor of zoledronic acid. Pearson's correlation demonstrated a statistically significant positive correlation between pain scores and response rates. There were no statistical differences in the narcotic scores among the treatment arms during the study period. The overall duration of pain relief was not different in any of treatment arms. The time of detection of hypercalcemia was no different; however, the incidence of hypercalcemia was significantly less in the zoledronic acid arm (28.3%) against 44.6% and 50% in ibandronate and pamidronate arms, respectively, with a P-value of 0.041. Conclusion: The use of bisphosphonates for 6 months or more results in a statistical significant improvement in bone pain, more so with zoledronic acid. Hypercalcemia, an SRE, was significantly less in the zoledronic acid arm.
Phosphorylation-induced structural changes in smooth muscle myosin regulatory light chain

We have performed complementary time-resolved fluorescence resonance energy transfer (TR-FRET) experiments and molecular dynamics (MD) simulations to elucidate structural changes in the phosphorylation domain (PD) of smooth muscle regulatory light chain (RLC) bound to myosin. PD is absent in crystal structures, leaving uncertainty about the mechanism of regulation. Donor-acceptor pairs of probes were attached to three site-directed di-Cys mutants of RLC, each having one Cys at position 129 in the C-terminal lobe and the other at position 2, 3, or 7 in the N-terminal PD. Labeled RLC was reconstituted onto myosin subfragment 1 (S1). TR-FRET resolved two simultaneously populated structural states of RLC, closed and open, in both unphosphorylated and phosphorylated biochemical states. All three FRET pairs show that phosphorylation shifts the equilibrium toward the open state, increasing its mol fraction by ∼20%. MD simulations agree with experiments in remarkable detail, confirming the coexistence of two structural states, with phosphorylation shifting the system toward the more dynamic open structural state. This agreement between experiment and simulation validates the additional structural details provided by MD simulations: In the closed state, PD is bent onto the surface of the C-terminal lobe, stabilized by interdomain salt bridges. In the open state, PD is more helical and straight, resides farther from the C-terminal lobe, and is stabilized by an intradomain salt bridge. The result is a vivid atomic-resolution visualization of the first step in the molecular mechanism by which phosphorylation activates smooth muscle.
Moisture Absorption and Fracture Toughness of PEEK Polymer and Graphite Fiber Reinforced PEEK

Tests were conducted to determine the moisture absorption characteristics of PEEK 150P polymer and APC-2 composite exposed to humid air, and to evaluate the effects of moisture content and crystallinity on the fracture toughness. Tests were con ducted with PEEK 150P specimens having 30, 34, and 43 percent crystallinities and with APC-2 specimens having 17 and 21 percent crystallinities. The weight gains of these speci mens were measured during exposure to air kept at relative humidities ranging from 60 to 100 percent and temperatures ranging from 140 to 200°F. The values of the maximum moisture content and diffusivity were deduced from the weight gain data. Empirical cor relations were established for the maximum moisture content and for the diffusivity. The room temperature fracture toughnesses of PEEK 150P and APC-2 were measured. For the conditions of the tests the fracture toughness was found to be unaffected by crystallinity and by moisture content.
Effect of Acetylation and MAPE on the Properties of Steam-Exploded Acacia mangium Fiber—HDPE Composites

Composites of high-density polyethylene (HDPE) and alkali-extracted steam-exploded Acacia mangium fiber (AEF) were prepared using 2-roll mill and compression molding. AEF was acetylated (AAEF) to three different wt% gains (WPG) and maleic anhydride grafted polyethylene (MAPE) was used as compatibilizer. Acetylation of AEF (AAEF) did not improve the tensile properties, particularly tensile strength of the composites. Addition of maleic anhydride-grafted polyethylene (MAPE) to either HDPE—AEF or HDPE—AAEF composites improved the composite strength. The effectiveness of MAPE, however, was limited by the weight percent gain (WPG) of AAEF resulting in a decrease in composite strength and stiffness. Sorption kinetics and characteristics of water absorption of the composites immersed in distilled water at room temperature for 30 days were determined and compared. All composites were found to exhibit Fickian diffusion process. Results showed that acetylation and MAPE reduced equilibrium water uptake as well as rate of water absorption (diffusion coefficient) of the composites. A synergistic effect, however, was only observed for the equilibrium water uptake when both were considered in a composite formulation.
The first unprovoked, untreated seizure in childhood: a hospital based study of the accuracy of the diagnosis, rate of recurrence, and long term outcome after recurrence. Dutch study of epilepsy in childhood

OBJECTIVE To assess the accuracy of the diagnosis of a first unprovoked seizure in childhood, the recurrence rate within two years, the risk factors for recurrence, and the long term outcome two years after recurrence. METHODS One hundred and fifty six children aged 1 month to 16 years after a first seizure, and 51 children with a single disputable event were followed up. The diagnosis of a seizure was confirmed by a panel of three child neurologists on the basis of predescribed diagnostic criteria. None of the children was treated after the first episode. RESULTS Five children with a disputable event developed epileptic seizures during follow up. The diagnosis did not have to be revised in any of the 156 children with a first seizure. The overall recurrence rate after two years was 54%. Significant risk factors were an epileptiform EEG (recurrence rate 71%) and remote symptomatic aetiology and/or mental retardation (recurrence rate 74%). For the 85 children with one or more recurrences, terminal remission irrespective of treatment two years after the first recurrence was >12 months in 50 (59%), <six months in 22 (26%), and six to 12 months in 11 (13%) and unknown in two (2%). Taking the no recurrence and recurrence groups together, a terminal remission of at least 12 months was present in 121 out of the 156 children (78%). CONCLUSIONS The diagnosis of a first seizure can be made accurately with the help of strict diagnostic criteria. The use of these criteria may have contributed to the rather high risk of recurrence in this series. However, the overall prognosis for a child presenting with a single seizure is excellent, even if treatment with antiepileptic drugs is not immediately instituted.
Functional localization in the cerebellum. II. Somatotopic organization in cortex and nuclei.

A new concept of the organization of the cerebellum into longitudinal, corticonuclear zones has been formulated (Chambers and Sprague14) on the basis of anatomical studies of Jansen and Brodal* and on our own physiological observations. † This concept stresses the importance of localization in the efferent corticonuclear projections, rather than the distribution of afferent fibers in the cerebellar cortex, in the interpretation of the results obtained by stimulation and ablation. Three bilaterally symmetrical zones have been defined in the cat (Fig. 1): (a) Each medial zone (vermal cortex and fastigial nucleus) regulates the tone, posture, locomotion, and equilibrium of the entire body; (b) each intermediate zone (paravermal cortex and nucleus interpositus) regulates the spatially organized and skilled movements and the tone and posture associated with these movements of the ipsilateral limbs, and (c) each lateral zone (hemispherical cortex and dentate nucleus) is involved in the same skilled and spatially organized
Epigenetic modification in congenital heart diseases by using stem cell technologies

Congenital heart diseases are the most common birth defects, occurring in more than 1% of newborns. The gene regulatory network of cardiac development has been revealed and some cases of congenital heart diseases have been shown to be associated with cardiac-specific gene mutations or related chromosomal abnormalities; however, almost all cases of congenital heart diseases are sporadic and the pathogenesis of heart malformations still remains unknown. Recently, studies of epigenetic regulation have been making progress in the field of cardiac development and the accumulated knowledge helps us understand more about cardiogenesis and congenital heart diseases. Interestingly, pluripotent stem cells such as embryonic stem (ES) cells and induced pluripotent stem (iPS) cells have attracted attention as tools to dissect epigenetic regulation during differentiation. Reprogramming and differentiation of ES cells and iPS cells can be induced by changes of gene expression patterns and epigenetic regulation, not by changing DNA sequences. We can also modify histone patterns and chromatin structures using chemical reagents. Hence, pluripotent stem cells enable us to dissect and modify epigenetic regulation during cardiogenesis in vitro. Moreover, in terms of iPS cells, they have become disease models because they can be generated from the somatic cells of patients. In this review, we summarize the recent findings of epigenetic regulation in cardiac development and congenital heart diseases. We also review the epigenetic modification during the reprogramming and cardiac differentiation of ES cells and iPS cells, and introduce our study showing that the disease-specific iPS cells of hypoplastic left heart syndrome, one of the severest congenital heart diseases with single ventricular circulation, exhibit unique epigenetic regulation during differentiation. Furthermore, we briefly focus on modifications of epigenetic regulation in cardiac development using chemical reagents, which suggest the possibility of treating congenital heart diseases using drugs. Lastly, we discuss the epigenetic memory of iPS cells, a specific feature that often complicates or prevents study of the differentiation of iPS cells.
A Critique of Laser-Induced Incandescence for the Measurement of Soot

The health and environmental risks due to airborne nanoparticles are important issues facing the citizens and governments of the industrialized countries. To assess and mitigate these risks, increasingly stringent regulations are being enacted to reduce the particulate emissions from the combustion of hydrocarbon fuels, which primarily consist of soot. Improvements to the understanding of the formation of soot nanoparticles and their impact on the health and the environment are required. This necessitates advances in the state of quantitative measurement of soot. Laser-induced incandescence (LII) is an optical diagnostic technique for the measurement of concentration and primary particle diameter of soot with high selectivity. Limitations with conventional LII were identified and a significantly enhanced technique, autocompensating LII (AC-LII), was developed employing timeresolved two-colour pyrometry, low fluence, and an absolute intensity calibration to address these limitations. AC-LII was shown to measure the soot particle temperature and automatically compensate for variations in the measurement environment that affected the peak soot particle temperature. With low fluence, AC-LII was shown to avoid soot sublimation, which impacted the measurements of concentration and size with high fluences. AC-LII was applied to flames and to combustion-generated emissions. At low ambient temperatures it was discovered that the measured concentration varied with fluence. To mitigate this issue, it was recommended that AC-LII be performed at a moderate fluence near the sublimation threshold. In order to assess the impact of distributions of the soot primary particle diameter and of aggregate size, analysis coupling experiments with a state-of-the-art numerical model of the heat transfer was performed. The results showed that AC-LII signal evaluation should begin immediately after an initial anomalous cooling period but before distribution effects become dominant. The sensitivity of AC-LII was optimized and applied to measure atmospheric black carbon concentrations. Comparison to other instruments demonstrated that AC-LII has significant advantages for the measurement of soot, and represents a major advancement in techniques for nanoparticle characterization.
Computing simulated endolymphatic flow thermodynamics during the caloric test using normal and hydropic duct models

Abstract Conclusion: The obtained simulations support the underlying hypothesis that the hydrostatic caloric drive is dissipated by local convective flow in a hydropic duct. Objective: To develop a computerized model to simulate and predict the internal fluid thermodynamic behavior within both normal and hydropic horizontal ducts. Methods: This study used a computational fluid dynamics software to simulate the effects of cooling and warming of two geometrical models representing normal and hydropic ducts of one semicircular horizontal canal during 120 s. Results: Temperature maps, vorticity, and velocity fields were successfully obtained to characterize the endolymphatic flow during the caloric test in the developed models. In the normal semicircular canal, a well-defined endolymphatic linear flow was obtained, this flow has an opposite direction depending only on the cooling or warming condition of the simulation. For the hydropic model a non-effective endolymphatic flow was predicted; in this model the velocity and vorticity fields show a non-linear flow, with some vortices formed inside the hydropic duct.