Miracle-dz/UniFAR-FTUs huggingface dataset:
Exclusion-based Signature Matching for Intrusion Detection

We consider the problem of efficient string-based signature matching for Network Intrusion Detection Systems (NIDSes). String matching computations dominate in the overall cost of running a NIDS, despite the use of efficient generalpurpose string matching algorithms. Aiming at increasing the efficiency and capacity of NIDSes, we have designed ExB, a string matching algorithm tailored to the specific characteristics of NIDS string matching. We have implemented ExB in snort and present experiments comparing ExB with the current best alternative solution. Our preliminary experiments suggest that ExB offers improvements in overall system performance by as much as a factor of three.
If the KI Is Defined by the Free Energy of Binding to P-Glycoprotein, Which Kinetic Parameters Define the IC50 for the Madin-Darby Canine Kidney II Cell Line Overexpressing Human Multidrug Resistance 1 Confluent Cell Monolayer?

From previous fits of drug transport kinetics across confluent Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 cell monolayers, we found that a drug's binding constant to P-glycoprotein (P-gp) was significantly smaller than its IC50 when that drug was used as an inhibitor against another P-gp substrate. We tested several IC50 candidate functions, including the standard function, the Kalvass-Pollack function, and the efflux ratio, to determine whether any of them yielded an IC50 = KI, as would be expected for water-soluble enzymes. For the confluent cell monolayer, the IC50/KI ratio is greater than 1 for all candidate functions tested. From the mass action kinetic model, we have derived a simple approximate equation that shows how the IC50/KI ratio depends on the elementary rate constants from our mass action model. Thus, the IC50 will differ between cell lines and tissues, for the same probe substrate and inhibitor, if there are different membrane concentrations of P-gp, or the probe substrate's elementary rate constants, partition coefficient, binding constant to P-gp, passive permeability, and ability to access the other transporters (if any) in the two cell lines. The mass action model and the approximate equation for the IC50/KI ratio derived here can be used to estimate the elementary rate constants needed to extrapolate in vitro drug-drug interactions for compounds to the in vivo environment.
Food Sources and Intake of Calcium in a Representative Sample of Spanish Adults

The present study aimed to assess calcium intake, dietary sources of this nutrient and its adequacy with respect to the dietary reference intake (DRI) in a representative sample of Spanish adults. In this study 418 adults (18 to 60 years) from 15 Spanish provinces were studied. Energy and nutrient intake was determined using a 24-hour recall questionnaire for two days. Adequacy of calcium intake was assessed using the established DRI for calcium. Anthropometric data (weight and height) were measured and the body mass index was calculated. Seventy eight percent of the participants in the study did not meet the DRI for calcium. Additionally, 33.7% of the participants did not meet the 67% of the DRI. The daily intake of calcium was 916.6 ± 288.1 mg/day, which represented the 81.3% of the DRI of calcium. Interestingly, subjects who had higher intake of calcium were taller. Additionally, it has been observed that individuals with normal body weight (BMI 2) had higher intakes of dairy products in comparison with overweight and obese individuals (BMI ≥ 25 kg/m2). The main food sources of calcium were dairy products (58.7% of calcium), cereals (13.6%) and vegetables (6.5%). Less than 1% (0.5%) of the calcium intake came from dietary supplements. It was observed that individuals who met the DRI for calcium had a significantly higher intake of dairy products (551.3 ± 240.4 g/day) than individuals who did not meet the DRI of calcium (305.0 ± 150.3 g/day). Calcium intake was inadequate in this sample of the adult Spanish population. Therefore, an increase in the consumption of dairy products, as well as cereals, vegetables and food items fortified with calcium seems to be necessary to achieve an adequate intake of calcium and to prevent diseases caused by calcium deficiency.
IL-9-Mediated Induction of Eotaxin1/CCL11 in Human Airway Smooth Muscle Cells1

Recent work has shown the potential importance of IL-9 in allergic diseases. The development of transgenic mice overexpressing IL-9 has suggested a key role for this cytokine in the development of the asthmatic phenotype including airway eosinophilia. In this study, we evaluated the expression of the IL-9R and the effects of IL-9 on human ASM cells by examining the release of Th2-associated chemokines (eotaxin1/CCL11 and thymus- and activation-regulated chemokine (TARC)/CCL17). IL-9R α-chain mRNA and surface expression were detected in cultured human airway smooth muscle (ASM) cells. In addition, primary cultured ASM cells, as well as bronchial smooth muscle cells within biopsies of asthmatics and not control subjects, revealed IL-9R protein expression. IL-9 stimulation of human ASM cells resulted in release of eotaxin1/CCL11, but had no effect on the release of TARC/CCL17, in time- and dose-dependent manner. Moreover, in vitro chemotaxis assay demonstrated that conditioned medium from IL-9-stimulated ASM cells attracted human eosinophils. Neutralizing Abs to IL-9, but not to IL-4 or IL-13, reduced significantly IL-9-induced production of eotaxin1/CCL11 from ASM cells. Interestingly, real-time RT-PCR showed that IL-9 up-regulated eotaxin1/CCL11 mRNA expression, but had no effect on TARC/CCL17. Treatment with Act D abrogates IL-9-induced eotaxin1/CCL11 mRNA and protein release by ASM cells. Finally, transfection study using eotaxin1/CCL11 promoter luciferase construct confirmed that IL-9 induced eotaxin1/CCL11 at the transcriptional level. Taken together, these data provide new evidence demonstrating that IL-9-dependent activation of ASM cells contributes to eosinophilic inflammation observed in asthma.
Intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: The prospective, randomized IABP SHOCK Trial for attenuation of multiorgan dysfunction syndrome*

Objective:Patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction with cardiogenic shock (CS) are often treated with intra-aortic balloon pump counterpulsation (IABP), even though the evidence to support this is limited. We determined whether IABP as an addition to PCI-centered therapy ameliorates multiorgan dysfunction syndrome (MODS) in patients with acute myocardial infarction complicated by CS. Design:A prospective, randomized, controlled, open-label clinical trial recruiting patients between March 2003 and June 2004 (ClinicalTrials.gov ID NCT00469248). Setting:Tertiary care university hospital. Patients and Interventions:Forty-five consecutive patients with AMI and CS undergoing PCI were randomized to treatment with or without IABP. Measurements and Main Results:Acute Physiology and Chronic Health Evaluation (APACHE) II scores (primary outcome measure), hemodynamic values, inflammatory markers, and plasma brain natriuretic peptide (BNP) levels (secondary outcomes) were collected over 4 days from randomization. The prospective hypothesis was that adding IABP therapy to “standard care” would improve CS-triggered MODS. The addition of IABP to standard therapy did not result in a significant improvement in MODS (measured by serial APACHE II scoring over 4 days). IABP use had no significant effect on cardiac index or systemic inflammatory activation, although BNP levels were significantly lower in IABP-treated patients. Initial and serial APACHE II scoring correlated with mortality better than cardiac index, systemic inflammatory state, and BNP levels in this group of patients. Nonsurvivors had significantly higher initial APACHE II scores (29.9 ± 2.88) than survivors (18.1 ± 1.66, p < .05). Nevertheless, discrepancies among patients within the groups cannot be ruled out and might interfere with our results. Conclusions:In this randomized trial addressing addition of IABP in CS patients, mechanical support was associated only with modest effects on reduction of APACHE II score as a marker of severity of disease, improvement of cardiac index, reduction of inflammatory state, or reduction of BNP biomarker status compared with medical therapy alone. However, the limitations of our present trial preclude any definitive conclusion, but request for a larger prospective, randomized, multicentered trial with mortality as primary end point.
Dual Linear Regression Based Classification for Face Cluster Recognition

We are dealing with the face cluster recognition problem where there are multiple images per subject in both gallery and probe sets. It is never guaranteed to have a clear spatio-temporal relation among the multiple images of each subject. Considering that the image vectors of each subject, either in gallery or in probe, span a subspace, an algorithm, Dual Linear Regression Classification (DLRC), for the face cluster recognition problem is developed where the distance between two subspaces is defined as the similarity value between a gallery subject and a probe subject. DLRC attempts to find a "virtual" face image located in the intersection of the subspaces spanning from both clusters of face images. The "distance" between the "virtual" face images reconstructed from both subspaces is then taken as the distance between these two subspaces. We further prove that such distance can be formulated under a single linear regression model where we indeed can find the "distance" without reconstructing the "virtual" face images. Extensive experimental evaluations demonstrated the effectiveness of DLRC algorithm compared to other algorithms.
Metabolic Syndrome Among Urban Indian Young Adults : Prevalence and Associated Risk Factors

Background: We estimated the prevalence of metabolic syndrome among urban Indian young adults (18–25 years) as defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), Internation Diabetes Federation (IDF), and Indian consensus statement criteria. Method: We included 473 urban young adults through simple random sampling methodology to estimate the prevalence and associated risk factors for metabolic syndrome. Results: Prevalence of metabolic syndrome was estimated to be 3.6 [95% confidence interval (CI) 2.2–5.8], 6.6% (95% CI 4.6–9.1), and 8.7% (95% CI 6.4–11.6) using the NCEP ATP III, IDF, and Indian consensus statement criteria, respectively. Men had significantly higher waist circumference, systolic blood pressure, fasting blood glucose, and triglycerides, whereas mean concentrations of both high-density lipoprotein cholesterol (HDL-C) and total cholesterol were significantly higher among women. Low HDL-C (38.9%), high blood pressure (26%), and central obesity (16.1%) were the most common component risk factors. Although less than 4% of normal weight adults met the criteria for metabolic syndrome, rates increased in overweight individuals and reached a prevalence of 87% in the obese participants. In all, 61.3% of the total population had one or more risk factors for metabolic syndrome. Conclusion: The prevalence of metabolic syndrome is high among urban young adults in India, and it increased with increase in body mass index (BMI). Each component risk factor in isolated form—increased BMI, smoking, and history of hypertension—is an associated risk factor for metabolic syndrome. Although it is unclear whether metabolic syndrome screening in young Indians as a means to prevent adverse cardiovascular health outcomes is appropriate, healthy lifestyles should nevertheless be encouraged, and young adults should be considered as an important group for cardiovascular risk reduction programs.
Perception of Binaural Cues Develops in Children Who Are Deaf through Bilateral Cochlear Implantation

There are significant challenges to restoring binaural hearing to children who have been deaf from an early age. The uncoordinated and poor temporal information available from cochlear implants distorts perception of interaural timing differences normally important for sound localization and listening in noise. Moreover, binaural development can be compromised by bilateral and unilateral auditory deprivation. Here, we studied perception of both interaural level and timing differences in 79 children/adolescents using bilateral cochlear implants and 16 peers with normal hearing. They were asked on which side of their head they heard unilaterally or bilaterally presented click- or electrical pulse- trains. Interaural level cues were identified by most participants including adolescents with long periods of unilateral cochlear implant use and little bilateral implant experience. Interaural timing cues were not detected by new bilateral adolescent users, consistent with previous evidence. Evidence of binaural timing detection was, for the first time, found in children who had much longer implant experience but it was marked by poorer than normal sensitivity and abnormally strong dependence on current level differences between implants. In addition, children with prior unilateral implant use showed a higher proportion of responses to their first implanted sides than children implanted simultaneously. These data indicate that there are functional repercussions of developing binaural hearing through bilateral cochlear implants, particularly when provided sequentially; nonetheless, children have an opportunity to use these devices to hear better in noise and gain spatial hearing.
Antiplatelet and Anticoagulation Therapy for Acute Coronary Syndromes

The past 2 decades have witnessed the introduction and demise of several different antithrombotic medications for acute coronary syndromes. Part of the assessment of these compounds has been their effect on thrombotic events relative to the degree of increase in bleeding events. This review will outline the data supporting various antiplatelet and anticoagulant therapies and their combinations in patients with acute coronary syndromes and related disorders in both the acute and chronic phases of therapy.
Environmental controls on the Emiliania huxleyi calcite mass

Although ocean acidification is expected to impact (bio) calcification by decreasing the seawater carbonate ion concentration, [CO 3 2− ], there is evidence of nonuniform response of marine calcifying plankton to low seawater [CO 3 2− ]. This raises questions about the role of environmental factors other than acidification and about the complex physiological responses behind calcification. Here we investigate the synergistic effect of multiple environmental parameters, including seawater temperature, nutrient (nitrate and phosphate) availability, and carbonate chemistry on the coccolith calcite mass of the cosmopolitan coccolithophore Emiliania huxleyi , the most abundant species in the world ocean. We use a suite of surface (late Holocene) sediment samples from the South Atlantic and southwestern Indian Ocean taken from depths lying above the modern lysocline (with the exception of eight samples that are located at or below the lysocline). The coccolith calcite mass in our results presents a latitudinal distribution pattern that mimics the main oceanographic features, thereby pointing to the potential importance of seawater nutrient availability (phosphate and nitrate) and carbonate chemistry (pH and p CO 2 ) in determining coccolith mass by affecting primary calcification and/or the geographic distribution of E. huxleyi morphotypes. Our study highlights the importance of evaluating the combined effect of several environmental stressors on calcifying organisms to project their physiological response(s) in a high-CO 2 world and improve interpretation of paleorecords.
Multi-Determinants Analysis of Molecular Alterations for Predicting Clinical Benefit to EGFR-Targeted Monoclonal Antibodies in Colorectal Cancer

Background KRAS mutations occur in 35–45% of metastatic colorectal cancers (mCRC) and preclude responsiveness to EGFR-targeted therapy with cetuximab or panitumumab. However, less than 20% patients displaying wild-type KRAS tumors achieve objective response. Alterations in other effectors downstream of the EGFR, such as BRAF, and deregulation of the PIK3CA/PTEN pathway have independently been found to give rise to resistance. We present a comprehensive analysis of KRAS, BRAF, PIK3CA mutations, and PTEN expression in mCRC patients treated with cetuximab or panitumumab, with the aim of clarifying the relative contribution of these molecular alterations to resistance. Methodology/Principal Findings We retrospectively analyzed objective tumor response, progression-free (PFS) and overall survival (OS) together with the mutational status of KRAS, BRAF, PIK3CA and expression of PTEN in 132 tumors from cetuximab or panitumumab treated mCRC patients. Among the 106 non-responsive patients, 74 (70%) had tumors with at least one molecular alteration in the four markers. The probability of response was 51% (22/43) among patients with no alterations, 4% (2/47) among patients with 1 alteration, and 0% (0/24) for patients with ≥2 alterations (p<0.0001). Accordingly, PFS and OS were increasingly worse for patients with tumors harboring none, 1, or ≥2 molecular alteration(s) (p<0.001). Conclusions/Significance When expression of PTEN and mutations of KRAS, BRAF and PIK3CA are concomitantly ascertained, up to 70% of mCRC patients unlikely to respond to anti-EGFR therapies can be identified. We propose to define as ‘quadruple negative’, the CRCs lacking alterations in KRAS, BRAF, PTEN and PIK3CA. Comprehensive molecular dissection of the EGFR signaling pathways should be considered to select mCRC patients for cetuximab- or panitumumab-based therapies.
Influence of Selected Inhibitors on the Metabolism of the Styrene Metabolite 4-Vinylphenol in Wild-Type and CYP2E1 Knockout Mice

4-Vinylphenol (4-VP), a minor metabolite of styrene, is a more potent hepato- and pneumotoxicant than either styrene or styrene oxide. In CD-1 mice 4-VP is metabolized primarily by cytochrome P-450 (CYP) 2E1 and CYP2F2. However, there is no difference in the rate of metabolism of 4-VP between wild-type and CYP2E1 knockout mice, indicating that other cytochromes P-450 play an important role. To understand the role of various cytochromes P-450, the in vitro metabolism of 4-VP was measured in the presence of selected inhibitors. Chemical inhibitors used to ascertain the contributions made by various cytochromes P450 were imipramine for CYP2C, α-methylbenzylaminobenzotriazole (MBA) for CYP2B, α-naphthoflavone (ANF) for CYP1A, 5-phenyl-1-pentyne (5P1P) for CYP2F2, and diethyldithiocarbamate (DTTC) for CYP2E1. Imipramine, MBA, and ANF produced significant inhibition in both the wild-type and CYP2E1 knockout mouse liver with minimal effects in lung. 5P1P significantly inhibited enzymic activity in both tissues, but to a greater extent in lung. The greatest inhibition was observed with DDTC even in the knockout mice, suggesting that it must also inhibit cytochromes P-450 in addition to CYP2E1. The results show little difference between the wild-type and knockout mice with respect to the contributions made by the cytochromes P-450 in the metabolism of 4-VP.
Role of the 1-month protocol transarterial chemoinfusion in detecting intrahepatic metastasis after resection of large hepatocellular carcinoma greater than 10 cm

Backgrounds/Aims Tumor recurrence is very common after hepatic resection of hepatocellular carcinoma (HCC) ≥10 cm. The purpose of this study was to validate the prognostic significance of the preoperative alkaline phosphatase (ALP) level and early intrahepatic metastasis in HCC patients who underwent resection of large HCC. Methods Clinical data of 100 large HCC patients who underwent liver resection were retrospectively reviewed. All of them underwent protocol transarterial chemoinfusion (TACI) at 1 month. Results Median tumor diameter was 13.8 cm, and 94% were single lesions. Systematic and non-systematic resections were performed in 91% and 9%, respectively, with R0 resection achieved in 84%. Overall 1-, 3- and 5-year survival rates were 76%, 38.5%, and 30.4%, respectively. Univariate analyses on patient survival revealed that intrahepatic metastasis on 1-month protocol TACI was the only significant risk factor (p=0.002). Mean ALP values according to the intrahepatic metastasis on 1-month protocol TACI were 124.6±76.9 IU/L and 145.1±92.6 IU/L, which did not show a statistical difference (p=0.23). Conclusions In patients with large HCC, 1-month protocol TACI combined with hepatic resection may contribute to the early detection and timely treatment of potentially preexisting metastatic lesions.
Representing Compositionality based on Multiple Timescales Gated Recurrent Neural Networks with Adaptive Temporal Hierarchy for Character-Level Language Models

A novel character-level neural language model is proposed in this paper. The proposed model incorporates a biologically inspired temporal hierarchy in the architecture for representing multiple compositions of language in order to handle longer sequences for the character-level language model. The temporal hierarchy is introduced in the language model by utilizing a Gated Recurrent Neural Network with multiple timescales. The proposed model incorporates a timescale adaptation mechanism for enhancing the performance of the language model. We evaluate our proposed model using the popular Penn Treebank and Text8 corpora. The experiments show that the use of multiple timescales in a Neural Language Model (NLM) enables improved performance despite having fewer parameters and with no additional computation requirements. Our experiments also demonstrate the ability of the adaptive temporal hierarchies to represent multiple compositonality without the help of complex hierarchical architectures and shows that better representation of the longer sequences lead to enhanced performance of the probabilistic language model.
To Control or Not to Control? Bias of Simple Matching vs Difference-In-Difference Matching in a Dynamic Framework

In this paper, I examine whether the claim “the more control variables, the better” holds when matching in a dynamic context. I exhibit two situations where it is better not to control for past outcomes because DID matching is unbiased whereas matching on past outcomes is biased. I study the special case of evaluating a job training program, where both estimators are biased, borrowing a credible selection rule from Heckman, LaLonde, and Smith (1999) and relying on the parameters of the wage process estimated by MaCurdy (1982). I derive closed forms for the bias terms of the two estimators when the error terms are normally distributed. I show that DID matching performs better when used symmetrically around the period of enrollment, as implemented by Heckman, Ichimura, Smith, and Todd (1998). Matching is less biased than DID-matching when considering to use the first pre-enrollment period, but symmetric DID-matching is less biased than the less biased matching estimator.