Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of hypothermia combined with neural stem cell transplantation on recovery of neurological function in rats with spinal cord injury

The microenvironment of the injured spinal cord is hypothesized to be involved in driving the differentiation and survival of engrafted neural stem cells (NSCs). Hypothermia is known to improve the microenvironment of the injured spinal cord in a number of ways. To investigate the effect of NSC transplantation in combination with hypothermia on the recovery of rat spinal cord injury, 60 Sprague-Dawley female rats were used to establish a spinal cord hemisection model. They were divided randomly into three groups: A, spinal cord injury group; B, NSC transplantation group; and C, NSC transplantation + hypothermia group. At 1, 2, 4, 6 and 8 weeks post-injury, the motor function of all animals was evaluated using the Basso, Beattie and Besnaham locomotor scoring system and the inclined plane test. At 4 weeks post-transplantation, histological analysis and immunocytochemistry were performed. At 8 weeks post-transplantation, horseradish peroxidase nerve tracing and transmission electron microscopy were conducted to observe axonal regeneration. The outcome of hind limb motor function recovery in group C significantly surpassed that in group B at 4 weeks post-injury (P<0.05). Recovery was also observed in group A, but to a lesser degree. For the pathological sections no neural axonal were observed in group A. A few axon-like structures were observed in group B and more in group C. Horseradish peroxidase-labeled neurofibers and bromodeoxyuridine-positive cells were observed in the spinal cords of group C. Fewer of these cells were found in group B and fewer still in group A. The differences among the three groups were significant (P<0.05). Using transmission electron microscopy, newly formed nerve fibers and myelinated nerve fibers were observed in the central transverse plane in groups B and C, although these nerve fibers were not evident in group A. In conclusion, NSC transplantation promoted the recovery of hind limb function in rats, and combination treatment with hypothermia produced synergistic effects.
Neural Congruency Effects in the Multi-Source Interference Task Vanish in Healthy Youth after Controlling for Conditional Differences in Mean RT

According to the conflict monitoring model of cognitive control, reaction time (RT) in distracter interference tasks (e.g., the Stroop task) is a more precise index of response conflict than stimulus congruency (incongruent vs. congruent). The model therefore predicts that RT should be a reliable predictor of activity in regions of the posterior medial frontal cortex (pMFC) that are posited to detect response conflict. In particular, pMFC activity should be (a) greater in slow-RT than in fast-RT trials within a given task condition (e.g., congruent) and (b) equivalent in RT-matched trials from different conditions (i.e., congruent and incongruent trials). Both of these effects have been observed in functional magnetic resonance imaging (MRI) studies of adults. However, neither effect was observed in a recent study of healthy youth, suggesting that (a) the model does not accurately describe the relationship between RT and pMFC activity in this population or (b) the recent study was characterized by high variability due to a relatively small sample size. To distinguish between these possibilities, we asked a relatively large group of healthy youth (n = 28) to perform a distracter interference task - the multi-source interference task (MSIT) - while we recorded their brain activity with functional MRI. In this relatively large sample, both of the model’s predictions were confirmed. We conclude that the model accurately describes the relationship between pMFC activity and RT in healthy youth, but that additional research is needed to determine whether processes unrelated to response conflict contribute to this relationship.
The Benefit of Remote Microphones Using Four Wireless Protocols.

BACKGROUND Many studies have reported the speech recognition benefits of a personal remote microphone system when used by adult listeners with hearing loss. The advance of wireless technology has allowed for many wireless audio transmission protocols. Some of these protocols interface with commercially available hearing aids. As a result, commercial remote microphone systems use a variety of different protocols for wireless audio transmission. It is not known how these systems compare, with regard to adult speech recognition in noise. PURPOSE The primary goal of this investigation was to determine the speech recognition benefits of four different commercially available remote microphone systems, each with a different wireless audio transmission protocol. RESEARCH DESIGN A repeated-measures design was used in this study. STUDY SAMPLE Sixteen adults, ages 52 to 81 yr, with mild to severe sensorineural hearing loss participated in this study. INTERVENTION Participants were fit with three different sets of bilateral hearing aids and four commercially available remote microphone systems (FM, 900 MHz, 2.4 GHz, and Bluetooth(®) paired with near-field magnetic induction). DATA COLLECTION AND ANALYSIS Speech recognition scores were measured by an adaptive version of the Hearing in Noise Test (HINT). The participants were seated both 6 and 12' away from the talker loudspeaker. Participants repeated HINT sentences with and without hearing aids and with four commercially available remote microphone systems in both seated positions with and without contributions from the hearing aid or environmental microphone (24 total conditions). The HINT SNR-50, or the signal-to-noise ratio required for correct repetition of 50% of the sentences, was recorded for all conditions. A one-way repeated measures analysis of variance was used to determine statistical significance of microphone condition. RESULTS The results of this study revealed that use of the remote microphone systems statistically improved speech recognition in noise relative to unaided and hearing aid-only conditions across all four wireless transmission protocols at 6 and 12' away from the talker. CONCLUSIONS Participants showed a significant improvement in speech recognition in noise when comparing four remote microphone systems with different wireless transmission methods to hearing aids alone.
The Three-dimensional Structure of a Superantigen-like Protein, SET3, from a Pathogenicity Island of the Staphylococcus aureus Genome*

The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within the Staphylococcus aureus genome that were identified by their similarity to the well described bacterial superantigens. The first crystal structure of a member of the SET family, SET3, has been determined to 1.9 Å (R = 0.205, R free = 0.240) and reveals a fold characteristic of the superantigen family but with significant differences. The SET proteins are secreted at varying levels by staphylococcal isolates, and seroconversion studies of normal individuals indicate that they are strongly antigenic to humans. Recombinant SETs do not exhibit any of the properties expected of superantigens such as major histocompatibility complex class II binding or broad T-cell activation, suggesting they have an entirely different function. The fact that the whole gene family is clustered within the pathogenicity island SaIn2 of theS. aureus genome suggests that they are involved in host/pathogen interactions.
Power management of variation aware chip multiprocessors

Faced with the challenge of finding ways to use an ever-growing transistor budget, microarchitects have begun to move towards the chip multiprocessors (CMPs) as an attractive solution. CMPs have become a common way of reducing chip complexity and power consumption while maintaining high performance. Multiple cores are replicated on a single chip, resulting in a potential linear scaling of performance. Cores are becoming sufficiently small with technology scaling. As technology continues to scale, inter-die and intra-die variations in process parameters can result in significant impact on performance and power consumption, leading to asymmetry among the cores that were designed to be symmetric. Adaptive voltage scaling can be used to bring all cores to the same performance level leaving only core-to-core power variations. The goal of our work is to find the optimal frequency that balances performance with power against asymmetry. We also demonstrate that traditional task scheduling techniques need to be revisited to mitigate the effects of process variations.
Virtual Point-to-Point Links in Packet-Switched NoCs

A method to setup virtual point-to-point links between the cores of a packet-switched network-on-chip is presented in this paper which aims at reducing the NoC power consumption and delay. The router architecture proposed in this paper provides packet-switching, as well as a number of virtual point-to-point, or VIP (VIrtual Point-to-point) for short, connections. This is achieved by designating one virtual channel at each physical channel of a router to bypass the router pipeline. The mapping and routing algorithm exploits these virtual channels and tries to virtually connect the source and destination nodes of high-volume communication flows during task-graph mapping and route selection phase of the NoC design process. The evaluation results show a significant reduction in power and latency over a traditional packet-switched NoC.
The X-Ray Luminosity Function of Bright Galaxy Clusters in the Local Universe

We present the X-ray luminosity function (XLF) for clusters of galaxies derived from the RASS1 Bright Sample. The sample, selected from the ROSAT All-Sky Survey in a region of 2.5 sr within the southern Galactic cap, contains 130 clusters with flux limits in the range ~3-4×10−12 ergs cm-2 s-1 in the 0.5-2.0 keV band. A maximum likelihood fit with a Schechter function of the XLF over the entire range of luminosities (0.045-28.0×1044 ergs s-1) gives α=1.52+0.11−0.11, L*=3.80+0.70−0.55×1044 ergs s-1, and A=5.07±0.45×10−7 Mpc-3 (1044 ergs s-1)α-1. We investigate possible evolutionary effects within the sample, out to our redshift limit (z~0.3), finding no evidence for evolution. Our results are in good agreement with other local estimates of the XLF, implying that this statistic for the local universe is now well determined. Comparison with XLFs for distant clusters (0.3 < z < 0.6) shows that no evolution is present for LX ≲ 1044 ergs s-1. However, we detect differences at the 3 σ level between our local XLF and the distant one estimated by Henry et al. for the Einstein Extended Medium-Sensitivity Survey (EMSS) sample. This difference is still present when considering the EMSS sample revised by Nichol et al.
Are There Any Spillovers between Household and Firm Financing Frictions ? A Dynamic General Equilibrium Analysis

Economic commentators frequently imply the existence of positive spillovers between the nancing frictions a¤ecting households and rms, suggesting another way in which credit constraints may amplify aggregate shocks and increase the persistence of aggregate uctuations. To examine this possibility, I develop a new model that incorporates both rm and household external nance spreads while improving in several dimensions on existing frameworks. Contrary to a common intuition, the baseline Real Business Cycle model with credit constraints produces small negative spillovers between the costs of external nancing for rms and households. The key factor in this result is the income e¤ect of changes in the external nance premium on borrower labour supply. The reduction in householdscost of borrowing in a boom decreases labour supply, increases the risk free interest rate and crowds out investment, raising borrowing costs for nancially constrained rms. JEL classi cation: E3, E4, G3. Key words: Financial frictions, external nance premium, business cycles. 0I would like to thank my supervisors Francisco Ruge-Murcia and Onur Ozgur, as well as Matthieu Darracq Paries and seminar participants at the European Central Bank for helpful discussions and advice. All remaining errors are my own. 0Department of Economics, Universite de Montreal and CIREQ. email:bd.solomon@umontreal.ca
Identifying Chaotic FitzHugh-Nagumo Neurons Using Compressive Sensing

We develop a completely data-driven approach to reconstructing coupled neuronal networks that contain a small subset of chaotic neurons. Such chaotic elements can be the result of parameter shift in their individual dynamical systems and may lead to abnormal functions of the network. To accurately identify the chaotic neurons may thus be necessary and important, for example, applying appropriate controls to bring the network to a normal state. However, due to couplings among the nodes, the measured time series, even from non-chaotic neurons, would appear random, rendering inapplicable traditional nonlinear time-series analysis, such as the delay-coordinate embedding method, which yields information about the global dynamics of the entire network. Our method is based on compressive sensing. In particular, we demonstrate that identifying chaotic elements can be formulated as a general problem of reconstructing the nodal dynamical systems, network connections and all coupling functions, as well as their weights. The working and efficiency of the method are illustrated by using networks of non-identical FitzHugh–Nagumo neurons with randomly-distributed coupling weights.
7Li NMR relaxation study of Li+ binding in human erythrocytes.

We used 7Li NMR spin-lattice (T1) and spin-spin (T2) relaxation time measurements to investigate the binding of Li+ in human red blood cell (RBC) suspensions. In RBCs containing 1.4 mM Li+, the intracellular 7Li NMR T2 relaxation value (0.30 +/- 0.03 s) was much smaller than the corresponding T1 value (6.0 +/- 0.1 s), yielding a ratio of T1 to T2 of 20. For 1.5 mM LiCl solutions whose viscosities were adjusted to 5 cP with glycerol, the values of the T1/T2 ratios were as follows: 49 for unsealed RBC membrane (2.0 mg of protein/mL); 4.4 for spectrin (1.9 mg/mL); 1.5 for 5.4 mM 2,3-bisphosphoglycerate (BPG); 2.2 for 2.7 mM carbonmonoxyhemoglobin (COHb); 1.6 for 2.0 mM ATP; and 1.2 for a 50/50% (v/v) glycerol-water mixture. Intracellular viscosity and the electric field gradients experienced by Li+ when traversing the spectrin-actin network therefore are not responsible for the large values of the T1/T2 ratios observed in Li(+)-loaded RBCs. We conclude that the RBC membrane is the major Li+ binding site in Li(+)-loaded RBCs (Kb = 215 +/- 36 M-1) and that the binding of Li+ to COHb, BPG, spectrin-actin, or ATP is weak. Partially relaxed 7Li NMR spectra of Li(+)-containing RBC membrane suspensions indicated the presence of two relaxation components, one broad and one narrow. (ABSTRACT TRUNCATED AT 250 WORDS)
Extracellular Quaternary Ammonium Blockade of Transient Receptor Potential Vanilloid Subtype 1 Channels Expressed in Xenopus laevis Oocytes

Transient receptor potential vanilloid subtype 1 (TRPV1) channels are essential nociceptive integrators in primary afferent neurons. These nonselective cation channels are inhibited by local anesthetic compounds through an undefined mechanism. Here, we show that lidocaine inhibits TRPV1 channels expressed in Xenopus laevis oocytes, whereas the neutral local anesthetic, benzocaine, does not, suggesting that a titratable amine is required for high-affinity inhibition. Consistent with this possibility, extracellular tetraethylammonium (TEA) and tetramethylammonium application produces potent, voltage-dependent pore block. Alanine substitutions at Phe649 and Glu648, residues in the putative TRPV1 pore region, significantly abrogated the concentration-dependent TEA inhibition. The results suggest that large cations, shown previously to enter cells through activated transient receptor potential channels, can also act as channel blockers.
Intracellular Calcium Homeostasis in a Human Neuroblastoma Cell Line: Modulation by Depolarization, Cholinergic Receptors, and α‐Latrotoxin

Abstract: Intracellular calcium homeostasis and its modulation by different agents was studied in cells by using the by using the Ca2+‐sensitive fluorescent dye quin2. The results obtained demonstrate the existence in IMR32 cells of (a) voltage‐dependent, verapamil sensitive, Ca2+ channels, which are expressed before differentiation; (b) muscarinic receptors whose activation triggers both Ca2+ influx and Ca2+ redistribution from intracellular stores, whereas nicotinc receptors and α‐bungarotoxin binding sites do not; and (c) receptors for α‐latrotoxin (the major toxin of the black widow spider venom), which are well‐known markers of the neuronal presynaptic membrane. Up to now, no cell lines of human origin sensitive to this toxin have been identified. These results confirm that IMR32 cells are very convenient model cells for studying specific aspects of the neurochemistry and neurobiology of the human neuron at the molecular and cellular levels.
Association of Adiponectin Gene Polymorphisms With the Risk of Coronary Artery Disease in Patients With Nonalcoholic Fatty Liver Disease in a Chinese Han Population

Background Cardiovascular events are an independent risk factor for nonalcoholic fatty liver disease (NAFLD), which is the leading cause of mortality in NAFLD patients. Several recent studies demonstrated that adiponectin (Ad) polymorphisms were involved in the progression of NAFLD and coronary artery disease (CAD). However, reports on the association between Ad polymorphisms and the risk of developing CAD in NAFLD patients are lacking in a Northern Han Chinese population. Objectives The present study was designed to evaluate the association between Ad gene polymorphisms (rs266729 and rs2241766) and the risk of developing CAD in Northern Han Chinese patients with NAFLD. Materials and Methods In this case-control study, using the polymerase chain reaction (PCR), Adrs266729 and rs2241766 gene polymorphisms were genotyped in B-type ultrasonography-proven NAFLD patients, with (n = 246) or without (n = 247) CAD and in healthy controls (n = 304). Serum lipid profiles were determined using biochemical methods. Statistical analyses were performed using SPSS 17.0 statistical software. Results There were significant differences in the Adrs266729 G allele between the NAFLD patients with and without CAD (P < 0.05). In addition, there was a significant difference in the Adrs2241766 G allele of the NAFLD patients compared with that of the controls (P < 0.05). In the NAFLD CAD population, carriers of the G allele of Adrs266729 had higher serum triglycerides (TG), total cholesterol (TC), fasting plasma glucose (FPG), and low-density lipoprotein (LDL) levels and a lower Ad level than their noncarrier counterparts (P = 0.031, P = 0.034, P = 0.007, P < 0.001, and P < 0.001, respectively). NAFLD patients without CAD had higher TG and serum FPG values and a lower Ad level than their noncarrier counterparts (P = 0.014, P = 0.038, and P < 0.001, respectively). In the NAFLD patients with/without CAD, the carriers of the G allele of Adrs2241766 had higher TG levels (P = 0.039 and P = 0.042, respectively) than those of their noncarrier counterparts. Conclusions In this Northern Chinese Han population, the Adrs266729 and rs2241766 G alleles were closely associated with the occurrence of NAFLD. However, only NAFLD patients who carried the Adrs266729 G allele had an increased risk of developing CAD.
Using multidimensional item response theory to understand what items and tests are measuring

Item response theory (IRT) describes the interaction between examinees and items using probabilistic models. One of the underlying assumptions of IRT is that examinees are all using the same skill or same composite of multiple skills to respond to each of the test items. When item response data do not satisfy the unidimensionality assumption, multidimensional item response theory (MIRT) should be used to model the item-examinee interaction. MIRT enables one to model the interaction of items that are capable of discrimi- nating between levels of several different abilities and examinees that vary in their proficiencies on these abilities. In this article graphical MIRT analyses designed to provide better insight into what individual items are measuring as well as what the test as a whole is assessing are presented and discussed. The goal of the article is to encourage testing practitioners to use MIRT as a means to statistically validate the test specifications.
Type-2 diabetes and coronary heart disease: common physiopathology, viewed from autoimmunity

Two highly prevalent diseases, Type-2 diabetes mellitus and coronary heart disease (CHD), share risk factors. Excess levels of LDL-cholesterol have been overemphasized to uniformly encompass the development of CHD, and the origin of insulin resistance underlying Type-2 diabetes has not been fully elucidated. Autoimmune response has been recognized to be responsible only of a small minority of diabetes. The increasing trend in the worldwide prevalence of diabetes and the risk factors for both diseases are reviewed, the independent mediation for CHD of (central) adiposity in both diseases and the ‘hypertriglyceridemic waist’ phenotype are outlined. Evidence is described that serum lipoprotein (Lp)(a) concentrations, not only in excess, but also in apparently ‘reduced’ levels, as a result of autoimmune response, underlie both disorders and are closely related to insulin resistance.
‘Callback’: increasing access to, and improving choice in, a multi-level, multi-purpose low-intensity service

Abstract In a previous paper auditing individual therapy in the STEPS team, we demonstrated a significant problem with attrition for both CBT and person-centred therapy. We argued that a root-and-branch change to the referral process was needed. This paper looks at the system which replaced it. ‘Callback’ allows self-referral with service users able to leave a phone message at any time. Clinicians call back and carry out a protocol-driven assessment, arranging, where appropriate, services at the end of the call. Reporting on the first 2500 calls, 92% of callers were successfully called back. Individuals were, on average, called back in 8.4 hours. Eighty-six percent of callers were offered an intervention within the STEPS service. They entered these STEPS services, on average, 9.4 days after the initial phone call. Of all callers 15.6% were offered individual therapy. Of these, 93% attended the first appointment and 82% completed a course of treatment. The results suggest that Callback is a significant improvement on the GP-referral system it replaced and provide evidence supporting the utility of ‘multi-level, multi-purpose’ services in primary care.
Flavor Formation and Character in Cocoa and Chocolate: A Critical Review

Chocolate characters not only originate in flavor precursors present in cocoa beans, but are generated during post-harvest treatments and transformed into desirable odor notes in the manufacturing processes. Complex biochemical modifications of bean constituents are further altered by thermal reactions in roasting and conching and in alkalization. However, the extent to which the inherent bean constituents from the cocoa genotype, environmental factors, post-harvest treatment, and processing technologies influence chocolate flavor formation and relationships with final flavor quality, has not been clear. With increasing speciality niche products in chocolate confectionery, greater understanding of factors contributing to the variations in flavor character would have significant commercial implications.