Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality Characteristics of Noodles with added Germinated Black Quinoa Powder

In this study, the quality characteristics of noodles containing different amounts of germinated black quinoa were investigated. The powder of black quinoa with the highest antioxidative activation was selected; and composite flour was prepared with 0%, 5%, 10%, 15%, and 20% of germinated black quinoa powder to produce the noodles. We evaluated the quality and sensory characteristics of the noodles, including pH, salinity, water absorption rate, volumetric expansion rate, turbidity, chromaticity, extensibility, and texture. With regards to the quality characteristics of noodles with added germinated black quinoa, the pH and salinity decreased with increasing percentage of added germinated black quinoa ( p <0.001). Increasing the percentage of added germinated black quinoa resulted in decreased water absorption ( p <0.01) and volumetric expansion rates and increased turbidity of the cooked noodles ( p <0.001). In terms of the chromaticity, L and b values decreased and a value increased with the increasing percentage of added germinated black quinoa ( p <0.001). For the texture, hardness ( p <0.001), adhesiveness ( p <0.01), springiness ( p <0.01), chewiness ( p <0.001), gumminess ( p <0.001), and cohesiveness ( p <0.05) decreased as the percentage of added germinated black quinoa increased; while extensibility ( p <0.001) increased. Consumer testing results indicated that the noodles with 15% of added germinated black quinoa showed the best results. Collectively, the evaluation of quality characteristics and consumer acceptability indicated that adding 15% of germinated black quinoa to produce noodles is optimal.
Astrocyte‐targeted expression of interleukin‐6 protects the central nervous system during neuroglial degeneration induced by 6‐aminonicotinamide

6‐Aminonicotinamide (6‐AN) is a niacin antagonist, which leads to degeneration of gray matter astrocytes mainly in the brainstem. We have examined the role of interleukin‐6 (IL‐6) in this degenerative process by using transgenic mice with astrocyte‐targeted IL‐6 expression (GFAP‐IL6 mice). This study demonstrates that transgenic IL‐6 expression significantly increases the 6‐AN‐induced inflammatory response of reactive astrocytes, microglia/macrophages, and lymphocytes in the brainstem. Also, IL‐6 induced significant increases in proinflammatory cytokines IL‐1, IL‐12, and tumor necrosis factor‐α as well as growth factors basic fibroblast growth factor (bFGF), transforming growth factor‐β, neurotrophin‐3, angiopoietin, vascular endothelial growth factor, and the receptor for bFGF. In accordance, angiogenesis was increased in GFAP‐IL6 mice relative to controls after 6‐AN. Moreover, oxidative stress and apoptotic cell death were significantly reduced by transgenic IL‐6 expression. IL‐6 is also a major inducer in the CNS of metallothionein I and II (MT‐I+II), which were significantly increased in the GFAP‐IL6 mice. MT‐I+II are antioxidants and neuroregenerative factors in the CNS, so increased MT‐I+II levels in GFAP‐IL6 mice could contribute to the reduction of oxidative stress and cell death in these mice. © 2003 Wiley‐Liss, Inc.
Bayesian inference and attentional modulation in the visual cortex

The responses of neurons in cortical areas V2 and V4 can be significantly modulated by attention to particular locations within an input image. We show that such effects emerge naturally when perception is viewed as a probabilistic inference process governed by Bayesian principles and implemented in hierarchical cortical networks. The proposed model can explain a rich variety of attention-related responses in cortical area V4 including multiplicative modulation of tuning curves, restoration of neural responses in the presence of distracting stimuli, and influence of attention on neighboring unattended locations. Our results suggest a new interpretation of attention as a cortical mechanism for reducing perceptual uncertainty by combining top-down task-relevant information with bottom-up sensory inputs in a probabilistic manner.
Motivation Matters: Differing Effects of Pre-Goal and Post-Goal Emotions on Attention and Memory

People often show enhanced memory for information that is central to emotional events and impaired memory for peripheral details. The intensity of arousal elicited by an emotional event is commonly held to be the mechanism underlying memory narrowing, with the implication that all sources of emotional arousal should have comparable effects. Discrete emotions differ in their effects on memory, however, with some emotions broadening rather than narrowing the range of information attended to and remembered. Thus, features of emotion other than arousal appear to play a critical role in memory narrowing. We review theory and research on emotional memory narrowing and argue that motivation matters. Recent evidence suggests that emotions experienced prior to goal attainment or loss lead to memory narrowing whereas emotions experienced after goal attainment or loss broaden the range of information encoded in memory. The motivational component of emotion is an important but understudied feature that can help to clarify the conditions under which emotions enhance and impair attention and memory.
Is Personal Insecurity a Cause of Cross-National Differences in the Intensity of Religious Belief?

Previous research has shown an apparent relationship between “societal health” and religiosity, with nations that exhibit higher mean personal religiosity also tending to provide worse social environments. A possible cause is that exposure to stressful situations (i.e. personal insecurity) increases personal religiosity. To test this hypothesis, income inequality, a widely available proxy for personal insecurity, was compared with other macro-scale causes of religiosity (derived from modernization and rational choice theories) in a multinational, cross-sectional analysis. Income inequality, and hence personal insecurity, was found to be an important determinant of religiosity in this diverse sample of nations.
Differential expression of plasma miR-146a in sepsis patients compared with non-sepsis-SIRS patients

Sepsis is a subtype of systemic inflammatory response syndrome (SIRS), which is characterized by infection. Circulating microRNAs (miRNAs), including miR-150, miR-146a and miR-223, are potential biomarkers of sepsis. In this study, we demonstrated that measuring the relative expression of miR-146a/U6 in plasma, using the 2−ΔΔCt method, provides a method for differentiating between sepsis and non-sepsis-SIRS. We observed a significant increase in miR-146a expression in the initial cohort of 6 non-sepsis-SIRS patients compared to the 4 sepsis patients (P=0.01) and in the second cohort of 8 non-sepsis-SIRS patients compared to the 10 sepsis patients (P=0.027). Additionally, we identified that sodium citrate and ethylenediaminetetraacetic acid (EDTA) K2 may be used as anticoagulant reagents. Generation of a standard curve is not necessary in these diagnostic tests, unless the standard of normalization is carefully selected. Thus we provide more detailed guidance for the clinical use of circulating miRNA biomarkers.
Certification and Integration of Environment with Quality and Safety - A Path to Sustained Success

© 2012 Santos et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Certification and Integration of Environment with Quality and Safety – A Path to Sustained Success
SherLog: error diagnosis by connecting clues from run-time logs

Computer systems often fail due to many factors such as software bugs or administrator errors. Diagnosing such production run failures is an important but challenging task since it is difficult to reproduce them in house due to various reasons: (1) unavailability of users' inputs and file content due to privacy concerns; (2) difficulty in building the exact same execution environment; and (3) non-determinism of concurrent executions on multi-processors. Therefore, programmers often have to diagnose a production run failure based on logs collected back from customers and the corresponding source code. Such diagnosis requires expert knowledge and is also too time-consuming, tedious to narrow down root causes. To address this problem, we propose a tool, called SherLog, that analyzes source code by leveraging information provided by run-time logs to infer what must or may have happened during the failed production run. It requires neither re-execution of the program nor knowledge on the log's semantics. It infers both control and data value information regarding to the failed execution. We evaluate SherLog with 8 representative real world software failures (6 software bugs and 2 configuration errors) from 7 applications including 3 servers. Information inferred by SherLog are very useful for programmers to diagnose these evaluated failures. Our results also show that SherLog can analyze large server applications such as Apache with thousands of logging messages within only 40 minutes.
Coverage and Load Balancing in Heterogeneous Cellular Networks with Minimum Cell Separation

In this paper, we consider a downlink heterogeneous cellular network (HCN) where K tiers operate in a common spectrum and differ in terms of transmit power, target data rate, and base station (BS) density. We employ a repulsive cell activation (or planning) in the HCN by ensuring a minimum separation distance between interfering BSs in each tier. We consider a modified Matern hardcore process (MHP) for rendering a minimum separation distance between the BSs, which is realized by outweighing random BS distribution for closed and open access networks. Repulsive cell activation not only improves the coverage probability but also plays a role in balancing per-cell loads effectively according to varying user density. Assuming a finite BS capacity in terms of a limited number of per-cell users, we point out the importance of a relative BS density control between the tiers, and propose a tier-wise density and power control by introducing a load factor for configuring a HCN distributively while satisfying per-tier user throughput constraints given user density.
Monitoring of 222Rn/220Rn concentrations at the work places of Muzaffarabad, Azad Kashmir

Thoron (220Rn), due to its-short half-life of 55.5 s is unable to travel far from its point of generation. A number of studies report indoor radon (222Rn) concentration in different locations of Azad Jammu and Kashmir, while no study reports indoor 220Rn concentration. The CR-39 based passive alpha track detectors were used for the measurement of 222Rn and 220Rn concentrations at different selected workplaces of Muzaffarabad. 222Rn and220Rn concentration were measured simultaneously. Alpha track detectors (ATD) were enclosed in a thin polyethylene film to exclude 220Rn (closed detector) while the other ATD has a coarse metal grid and cloth covering the large entry port allowing for rapid radon gas ingress. The results showed that the measured 222Rn concentration varied from 18.7 Bqm-3 to 160.2 Bqm-3 with an average value of 67.0 ± 3 Bq.m-3. Whereas the 220Rn concentration varied from 14.7 Bqm-3 to 100.4 Bqm-3 with an average value of 50.0 ± 2 Bqm-3. Preliminary results show that indoor 220Rn concentration is significantly higher and should be taken into consideration while calculating the dose due to radiation of natural origin. Key words: Thoron, indoor radon, alpha track detectors, radiation dose, Azad Jammu and Kashmir.
Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age

Objective: The effect of ghrelin on growth of the newborn has long been argued, but not fully clarified. In this study, we aimed to investigate the relationship between ghrelin levels and growth parameters in the first 3 months of life. Methods: The study included 60 babies (27 girls and 33 boys) born at gestational ages between 38-42 weeks. The newborns were divided into three groups according to the Lubchenco curves as: small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA). The relationship between ghrelin levels and growth parameters in the third month was investigated. Results: Ghrelin concentrations were significantly higher in SGA (2.4±2.6 ng/dL) babies than in AGA (1.3±0.9 ng/dL) and LGA (1.0±0.8 ng/dL) babies. The lowest ghrelin levels were in the LGA group. In SGA infants, ghrelin concentrations were inversely correlated with change in weight (r=-0.577; p=0.001), change in length (r=-0.361; p=0.005), and change in head circumference (r=-0.387; p=0.002). Conclusion: The results show that at age 3 months, SGA infants had higher ghrelin levels than AGA and LGA infants. Our findings indicate that ghrelin may be involved in the process of catch-up growth in these infants. Conflict of interest:None declared.
Cross-Layer Optimization Using Advanced Physical Layer Techniques in Wireless Mesh Networks

The objective of this paper is to study the impact of advanced physical layer techniques on the maximum achievable throughput of wireless multihop mesh networks. We formulate a cross-layer optimization framework for the routing and scheduling problem jointly with the following physical layer techniques: successive interference cancellation, superposition coding, dirty-paper coding and their combinations. In the case when each node is enabled with superposition coding, we need to formulate a power allocation subproblem for the optimal power partition of the superimposed signals. We solve these joint problems exactly to compute the maximum achievable throughput in realistic size networks. This allows us to quantify the performance gains obtained by using these techniques (and their combinations). Specifically, we find that the use of dirty-paper coding (only at the gateway) is not justified in networks with mixed uplink and downlink flows. On the other hand, the combination of superposition coding with successive interference outperforms significantly other techniques across all transmission power range for both uplink and downlink flows. We also provide a number of interesting practical insights on throughput improvement by comparing different combinations of these techniques.
Production of human tissue‐engineered skin trilayer on a plasma‐based hypodermis

Full thickness wounds require a dermal component to achieve functional permanent skin restoration. Currently available tissue‐engineered skin substitutes lack a subcutaneous fat layer that would functionally contribute some of the mechanical and thermoregulatory properties of normal skin. To generate a trilayer engineered skin equivalent, we included bone marrow mesenchymal (BM‐MSC) or adipose tissue‐derived (ASC) stromal cells in a human plasma hydrogel exposed to adipogenic clues for three weeks. Approximately half of the cells differentiated under these conditions into mature adipocytes that survived for two years in culture with minimal medium change. In vitro generation of bona fide fully differentiated adipocytes was assessed by leptin secretion and ultrastructurally demonstrated through semithin to ultrathin sectioning and lipid staining with osmium tetroxide. Furthermore, presence of BM‐MSCs or ASCs within the subcutaneous layer contributed to the epidermal differentiation program, with more proliferating basal cells depositing basal membrane proteins and differentiating into mature keratinocytes that were able to generate a pluristratified epithelium. In conclusion, we engineered a fully differentiated human skin trilayer that could present multiple applications such as use for in vitro drug absorption tests and regenerative therapies. Copyright © 2012 John Wiley & Sons, Ltd.
Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria

Background. The pharmacokinetics and pharmacodynamics of lumefantrine, a component of the most widely used treatment for malaria, artemether-lumefantrine, has not been adequately characterized in young children. Methods. Capillary whole-blood lumefantrine concentration and treatment outcomes were determined in 105 Ugandan children, ages 6 months to 2 years, who were treated for 249 episodes of Plasmodium falciparum malaria with artemether-lumefantrine. Results. Population pharmacokinetics for lumefantrine used a 2-compartment open model with first-order absorption. Age had a significant positive correlation with bioavailability in a model that included allometric scaling. Children not receiving trimethoprim-sulfamethoxazole with capillary whole blood concentrations <200 ng/mL had a 3-fold higher hazard of 28-day recurrent parasitemia, compared with those with concentrations >200 ng/mL (P = .0007). However, for children receiving trimethoprim-sulfamethoxazole, the risk of recurrent parasitemia did not differ significantly on the basis of this threshold. Day 3 concentrations were a stronger predictor of 28-day recurrence than day 7 concentrations. Conclusions. We demonstrate that age, in addition to weight, is a determinant of lumefantrine exposure, and in the absence of trimethoprim-sulfamethoxazole, lumefantrine exposure is a determinant of recurrent parasitemia. Exposure levels in children aged 6 months to 2 years was generally lower than levels published for older children and adults. Further refinement of artemether-lumefantrine dosing to improve exposure in infants and very young children may be warranted.
Indication of long-term endothelial dysfunction after sirolimus-eluting stent implantation.

AIMS Endothelial dysfunction has been related both to progression of atherosclerotic disease and to future cardiovascular events. We assessed local epicardial endothelial function 6 months after sirolimus-eluting stent (SES) or bare metal stent (BS) implantation. METHODS AND RESULTS In 12 patients (seven SES, five BS), endothelium-dependent vasomotion of a coronary segment 15 mm in length, starting 2 mm distal to the stent, was assessed with quantitative coronary angiography immediately after the procedure and at 6 months follow-up, after intracoronary infusion of acetylcholine. Intravascular ultrasound (IVUS) was performed and coronary flow reserve (CFR) assessed in all patients. At follow-up significant vasoconstriction was seen in SES (median 32% diameter reduction from baseline) but not in BS (median 2% reduction) patients after acetylcholine infusion (P=0.03 for SES vs. BS); endothelium-independent vasodilatation to nitrates did not differ significantly between groups (20% SES, 5% BS, P=0.14). IVUS revealed no late unhealed dissections and CFR was comparable between groups (SES 3.1 vs. BS 3.2, n.s.). CONCLUSION SES implantation may have an adverse effect on local endothelium-dependent vasomotor responses compared with BS implantation at 6 months. Long-term clinical consequences of this observation are still unknown.
Further studies on the activity and subcellular distribution of alanine:glyoxylate aminotransferase in the livers of patients with primary hyperoxaluria type 1.

1. The activity of alanine:glyoxylate aminotransferase (AGT; EC 2.6.1.44) has been measured in the unfractionated livers of 20 patients with primary hyperoxaluria type 1 (PH1), three patients with other forms of primary hyperoxaluria and one PH1 heterozygote. The subcellular distribution of AGT activity was examined in four of the PH1 livers and in the liver of the PH1 heterozygote. 2. The mean AGT activity in the unfractionated PH1 livers was 12.6% of the mean control value. The activities of other aminotransferases and the peroxisomal marker enzymes were normal. When corrected for cross-over from glutamate:glyoxylate aminotransferase (GGT; EC 2.6.1.4), the mean AGT activity in the PH1 livers was reduced to 3.3% of the control values. 3. The livers from a patient with primary hyperoxaluria type 2 (D-glycerate dehydrogenase deficiency) and one with an undefined form of primary hyperoxaluria (possibly oxalate hyperabsorption) had normal AGT levels. The livers of a very mild PH1-type variant and a PH1 heterozygote had intermediate levels of AGT activity. 4. Subcellular fractionation of four PH1 livers by sucrose gradient isopycnic centrifugation demonstrated a complete absence of peroxisomal AGT activity. The subcellular distribution of the residual AGT activity was very similar to that of GGT activity (i.e. mainly cytosolic with a small amount mitochondrial). There were no alterations in the subcellular distributions of any of the peroxisomal marker enzymes. The subcellular distribution of AGT activity in the PH1 heterozygote liver was similar to that of the control (i.e. mainly peroxisomal).
Effect of natural coagula maturation on the processability, cure, and mechanical properties of unfilled vulcanizates of Hevea natural rubber

Fresh latex from different Hevea brasiliensis clones was naturally coagulated, subjected to different durations of maturation, processed into solid rubber, and compounded into pure gum stocks and vulcanized. Coagula maturation had clone-specific effects on the processability of the raw rubber: reduced for some clones, while others was less sensitive. The cure and mechanical behaviors of the compounded stocks and vulcanizates, respectively, were not sensitive to the clonal origin of coagula and their duration of maturation. Although coagula maturation could be associated with leaching, deactivation of inherent antioxidants in Hevea latex, as well as crosslinking and/or oxidation of polyisoprene chains, these results show that compounding with a standard pure gum recipe compensates for the Hevea latex constituents affected by maturation. Hence, extended maturation of Hevea coagula, for economic or other reasons, would influence much more the bulk behavior of raw rubber and have insignificant effects on the compounded stocks and vulcanizates. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2359–2363, 2007
RNA-seq reveals distinctive RNA profiles of small extracellular vesicles from different human liver cancer cell lines

Liver cancer (LC) is one of the most common cancers and represents the third highest cause of cancer-related deaths worldwide. Extracellular vesicle (EVs) cargoes, which are selectively enriched in RNA, offer great promise for the diagnosis, prognosis and treatment of LC. Our study analyzed the RNA cargoes of EVs derived from 4 liver-cancer cell lines: HuH7, Hep3B, HepG2 (hepato-cellular carcinoma) and HuH6 (hepatoblastoma), generating two different sets of sequencing libraries for each. One library was size-selected for small RNAs and the other targeted the whole transcriptome. Here are reported genome wide data of the expression level of coding and non-coding transcripts, microRNAs, isomiRs and snoRNAs providing the first comprehensive overview of the extracellular-vesicle RNA cargo released from LC cell lines. The EV-RNA expression profiles of the four liver cancer cell lines share a similar background, but cell-specific features clearly emerge showing the marked heterogeneity of the EV-cargo among the individual cell lines, evident both for the coding and non-coding RNA species.