Miracle-dz/UniFAR-FTUs huggingface dataset:
Netupitant PET imaging and ADME studies in humans

Netupitant is a new, selective NK1 receptor antagonist under development for the prevention of chemotherapy‐induced nausea and vomiting. Two studies were conducted to evaluate the brain receptor occupancy (RO) and disposition (ADME) of netupitant in humans. Positron emission tomography (PET) imaging with the NK1 receptor‐binding–selective tracer [11C]‐GR205171 was used to evaluate the brain penetration of different doses of netupitant (100, 300, and 450 mg) and to determine the NK1‐RO duration. A NK1‐RO of 90% or higher was achieved with all doses in the majority of the tested brain regions at Cmax, with a long duration of RO. The netupitant minimal plasma concentration predicted to achieve a NK1‐RO of 90%, C90%, in the striatum was 225 ng/mL; after administration of netupitant 300 mg, concentrations exceeded the C90%. In the ADME study, a single nominal dose of [14C]‐netupitant 300 mg was used to assess its disposition. Absorption was rapid and netupitant was extensively metabolized via Phase I and II hepatic metabolism. Elimination of >90% was predicted at day 29 and was principally via hepatic/biliary route (>85%) with a minor contribution of the renal route (<5%). In conclusion, these studies demonstrate that netupitant is a potent agent targeting NK1 receptors with long lasting RO. In addition, netupitant is extensively metabolized and is mainly eliminated through the hepatic/biliary route and to a lesser extent via the kidneys.
Water Diffusion Changes in Wallerian Degeneration and Their Dependence on White Matter Architecture

This study investigates water diffusion changes in Wallerian degeneration. We measured indices derived from the diffusion tensor (DT) and T2-weighted signal intensities in the descending motor pathways of patients with small chronic lacunar infarcts of the posterior limb of the internal capsule on one side. We compared these measurements in the healthy and le-sioned sides at different levels in the brainstem caudal to the primary lesion. We found that secondary white matter degeneration is revealed by a large reduction in diffusion anisotropy only in regions where fibers are arranged in isolated bundles of parallel fibers, such as in the cerebral peduncle. In regions where the degenerated pathway crosses other tracts, such as in the rostral pons, paradoxically there is almost no change in diffusion anisotropy, but a significant change in the measured orientation of fibers. The trace of the diffusion tensor is moderately increased in all affected regions. This allows one to differentiate secondary and primary fiber loss where the increase in trace is considerably higher. We show that DT-MRI is more sensitive than T2-weighted MRI in detecting Wallerian degeneration. Significant diffusion abnormalities are observed over the entire trajectory of the affected pathway in each patient. This finding suggests that mapping degenerated pathways noninva-sively with DT-MRI is feasible. However, the interpretation of water diffusion data is complex and requires a priori information about anatomy and architecture of the pathway under investigation. In particular, our study shows that in regions where fibers cross, existing DT-MRI-based fiber tractography algorithms may lead to erroneous conclusion about brain connec-tivity.
Alcohol problems, aggression, and other externalizing behaviors after return from deployment: understanding the role of combat exposure, internalizing symptoms, and social environment.

OBJECTIVES The study examined whether elevated rates of externalizing behaviors following deployment could be explained by internalizing symptoms (depression, anxiety, and PTSD symptoms), and health of the social environment (unit leadership, organizational support, and stigma/barriers to care). DESIGN A model of combat exposure, social environment, internalizing symptoms, and externalizing behaviors was tested in a military unit following a fifteen-month deployment to Iraq. The sample included 1,397 soldiers assessed four month post-deployment; 589 of these soldiers were assessed again nine months post-deployment. RESULTS Externalizing behaviors were highly stable over the five-month post-deployment period. Both social environment and internalizing symptoms were significantly associated with level of externalizing behaviors at four months and nine months post-deployment, but combat exposure alone significantly predicted change in externalizing behaviors over the follow-up period. CONCLUSIONS Results suggest the need to broaden the scope of interventions targeted to combat veterans and have implications for care providers and military leaders.
Combined light exercise after meal intake suppresses postprandial serum triglyceride.

PURPOSE The effect of exercise performed on the day of meal intake on postprandial triglyceride concentration, which is an independent risk factor for cardiovascular disease, is unclear. The present study investigated the effects of combined low-intensity exercise before and after a high-fat meal on serum triglyceride concentrations. METHODS Ten healthy young subjects (four men and six women) consumed a relatively high-fat diet (fat energy ratio: men = 37.8%, women = 39.1%). In the exercise trials, subjects performed brisk walking (2.0 km) after light resistance exercise, either 60 min before or after meal intake. Blood samples were collected before and 2, 4, and 6 h after meal intake. RESULTS Exercise resulted in a reduction in the transient elevation in serum triglyceride concentration observed 2 h after meal intake in the postmeal trial (131 ± 67 mg·dL) when compared with the sedentary trial (172 ± 71 mg·dL; 95% confidence interval = 7.2-79.4, d = -1.00). This was also observed in the premeal trial, although the effect was less pronounced (148 ± 66 mg·dL; 95% confidence interval = -9.0 to 59.0, d = -0.57). The triglyceride concentrations in the VLDL, LDL, and HDL fractions, but not the chylomicron fraction, were also decreased 2 h after meal intake in both exercise trials, whereas the integrated triglyceride values after meal intake showed a greater decrease when exercise was performed after meal intake (d = -1.23) than before (d = -0.47). The concentration of serum growth hormone was drastically increased after exercise in both trials. CONCLUSIONS Low-intensity exercise on the day of meal intake, particular after intake, can prevent the elevation of postprandial triglyceride concentration in healthy young subjects.
Tight Bounds on Low-Degree Spectral Concentration of Submodular and XOS Functions

Submodular and fractionally subadditive (or equivalently XOS) functions play a fundamental role in combinatorial optimization, algorithmic game theory and machine learning. Motivated by learnability of these classes of functions from random examples, we consider the question of how well such functions can be approximated by low-degree polynomials in ℓ<sub>2</sub> norm over the uniform distribution. This question is equivalent to understanding the concentration of Fourier weight on low-degree coefficients, a central concept in Fourier analysis. Denoting the smallest degree sufficient to approximate f in ℓ<sub>2</sub> norm within ∈ by deg<sub>∈</sub>(ℓ<sub>2</sub>)(f), we show that : For any submodular function f : {0, 1}<sup>n</sup> → [0, 1], deg<sub>∈</sub>(ℓ<sub>2</sub>)(f) = O(log(1/∈)/∈<sup>4/5</sup>) and there is a submodular function that requires degree Ω(1/∈<sup>4/5</sup>). : For any XOS function f : {0, 1} → [0, 1], deg<sub>∈</sub>(ℓ<sub>2</sub>) (f) = O(1/∈) and there exists an XOS function that requires degree Ω(1/∈). This improves on previous approaches that all showed an upper bound of O(1/∈<sup>2</sup>) for submodular [CKKL12], [FKV13], [FV13] and XOS [FV13] functions. The best previous lower bound was Ω(1/∈<sup>2/3</sup>) for monotone submodular functions [FKV13]. Our techniques reveal new structural properties of submodular and XOS functions and the upper bounds lead to nearly optimal PAC learning algorithms for these classes of functions.
Internally heated convection beneath a poor conductor

We consider convection in an internally heated (IH) layer of fluid that is bounded below by a perfect insulator and above by a poor conductor. The poorly conducting boundary is modelled by a fixed heat flux. Using solely analytical methods, we find linear and energy stability thresholds for the static state, and we construct a lower bound on the mean temperature that applies to all flows. The linear stability analysis yields a Rayleigh number above which the static state is linearly unstable ( $R_{L}$ ), and the energy analysis yields a Rayleigh number below which it is globally stable ( $R_{E}$ ). For various boundary conditions on the velocity, exact expressions for $R_{L}$ and $R_{E}$ are found using long-wavelength asymptotics. Each $R_{E}$ is strictly smaller than the corresponding $R_{L}$ but is within 1 %. The lower bound on the mean temperature is proven for no-slip velocity boundary conditions using the background method. The bound guarantees that the mean temperature of the fluid, relative to that of the top boundary, grows with the heating rate ( $H$ ) no slower than $H^{2/3}$ .
Multiple airport ground holding dynamic model and optimal algorithm basing flight priority

With the increase of air transportation demand, the problem of air traffic congestion has become more and more serious, so the study of flow optimization management is of urgent need and great importance. Ground-holding policy (GHP) is regarded as one of the most effective methods of short-term air flow management to ease the air traffic congestion and improve the air safety. The essence of the GHP optimal algorithm is to decide which flight is to be delayed to take off and how long it is delayed.
Towards an information theory of large networks: an achievable rate region

We study communication networks of arbitrary size and topology under a general vector discrete memoryless channel (V-DMC). We propose an information-theoretic constructive scheme for obtaining an achievable rate region in such networks. Many well-known capacity-defining achievable rate regions can be derived as special cases of the proposed scheme; a few such examples are: degraded and reversely-degraded relay channels, Gaussian multiple access channel, and Gaussian broadcast channel. Applying the proposed scheme to a specific wireless network of n nodes located in a region of unit area, we show that a transport capacity of O(n) bit-meters/s is feasible.
Influence of Nutrient Management Practices on Growth and Yield of Pearl Millet in Melia dubia Based Agri-Silvi System

Pearl millet (Pennisetum glaucum L.), the world’s hardiest warm season cereal crop (Reddy et al., 2012). Globally it ranks sixth after rice, wheat, maize, barley and sorghum in terms of area (Khairwal et al., 2007) and share 42% of total world production (Ramesh et al., 2006). In India, it is the fifth most important cereal grain crop next to rice, wheat, maize and sorghum. Pearl millet is an indispensable arid and semi-arid crop of India (Ramesh et al., 2006) cultivated as dual purpose (food and feed) crop in over 7.12 m ha ranking fourth among total cereals (Agricultural Statistics at a Glance, 2016). The recent spurt in prices of wheat, rice and maize and growing demand for non-food uses (cattle and poultry feed, alcohol and starch industries), pearl millet became cheaper alternative sources (Reddy et al., 2013). Further, the nutritional value of this crop offers much scope to development of value added products in new health conscious consumer segments (Yadav et al., 2011) as it contains more fibre and is good for diabetic International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 7 Number 06 (2018) Journal homepage: http://www.ijcmas. com
The primary defect in experimental ileitis originates from a nonhematopoietic source

The initiating etiologic factor in Crohn's disease (CD) remains unclear. SAMP1/YitFc (SAMP) mice develop chronic ileitis similar to human CD. We used bone marrow chimeras to determine if SAMP ileitis results from a primary immunological defect or from dysregulated mucosal immunity secondary to intrinsic, nonhematopoietic (e.g., epithelial) dysfunction. SAMP mice receiving wild-type (AKR) BM developed severe ileitis, whereas SAMP BM did not confer ileitis to WT recipients. WT lymphocytes from reconstituted SAMP mice resembled native SAMP populations in regard to surface phenotype and cytokine production. Ilea from native SAMP mice and SAMP recipients of wild-type BM displayed decreased epithelial barrier resistance ex vivo and increased epithelial permeability in vivo compared to native WT mice and AKR recipients of SAMP BM. This permeability defect preceded the development of ileal inflammation, was present in the absence of commensal bacteria, and was accompanied by altered ileal mRNA expression of the tight junction proteins claudin-2 and occludin. Our results provide evidence that the primary defect conferring ileitis in SAMP mice originates from a nonhematopoietic source. Generation of pathogenic lymphocytes is a consequence of this defect and does not reflect intrinsic proinflammatory leukocyte properties. Decreased barrier function suggests that defects in the epithelium may represent the primary source of SAMP ileitis susceptibility.
A Component- and Message-Based Architectural Style for GUI Software

While a large fraction of application system code is devoted to user interface (UI) functions, support for reuse in this domain has largely been confined to creation of UI toolkits ("widgets"). We present a novel architectural style directed at supporting larger grain reuse andjexible system composition. Moreover, the style supports design of distributed, concurrent, applications. A key aspect of the style is that components are not built with any dependencies on what typically would be considered lower-level components, such as user interface toolkits. Indeed, all components are oblivious to the existence of any components to which notification messages are sent. Asynchronous notification messages and asynchronous request messages are the sole basis for inter-component communication. While our focus has been on applications involving graphical user interfaces, the style has the potential for broader applicability. Several trial applications using the style are described.
Transcervical recovery of fetal cells from the lower uterine pole: reliability of recovery and histological/immunocytochemical analysis of recovered cell populations.

The aim of this work was to isolate, enumerate and attempt the identification of fetal cells recovered from the lower uterine pole. Immediately before elective termination of pregnancy at 7-17 weeks gestation, samples were recovered by transcervical flushing of the lower uterine pole (n = 108) or transcervical aspiration of mucus from just above the internal os (n = 187), and their contents examined using histological, immunohistochemical and molecular techniques. Syncytiotrophoblasts were identified morphologically in 28 out of 89 (31%) and 50 out of 180 (28%) flushings and aspirates respectively (mean 29%). Immunocytochemistry with monoclonal antibodies (mAbs) recognizing trophoblast or epithelial cell antigens on a smaller number of samples (n = 69) identified putative placental cells in 13 out of 19 (68%) and 25 out of 50 (50%) flushings and aspirates respectively (mean 55%). These included groups of distinctive cells with a small, round, hyperchromatic nucleus, strongly reactive with mAbs PLAP, NDOG1 and FT1.41. 1. Smaller groups of larger, amorphous cells, usually containing multiple large, pale staining nuclei, reactive with mAb 340 and to a lesser degree with mAb NDOG5 were also observed. Taking cellular morphology and immunophenotype into consideration, the smaller uninucleate cells were likely to be villous mesenchymal cells, while the larger cells were possibly degrading villous syncytiotrophoblast. There was no significant difference in the frequency of fetal cells obtained by the two recovery methods. Squamous or columnar epithelial cells, labelled strongly with antibodies to cytokeratins or human milk fat globule protein, were observed in 97% (29 out of 30) of aspirates. The use of cervagem in a small number of patients prior to termination of pregnancy did not appear to influence the subsequent recovery of placental cells. Y-specific DNA was detected by polymerase chain reaction (PCR) in 13 out of 26 (50%) flushings and (99 out of 154) 64% aspirates analysed (mean 62%). In-situ hybridization (ISH) revealed Y-specific targets in 40 out of 69 (60%) of aspirates analysed. A comparison of PCR data obtained from transcervical recovered samples and placental tissues showed a concordance of 80% (76 out of 95), with 10 false positives. Comparing the PCR data from tissues with data derived by ISH from 41 aspirates gave a concordance of 90% with two false positives. Although syncytiotrophoblasts were much more likely to be present in samples containing immunoreactive placental cells, the detection rates of fetal-derived DNA were similar regardless of the morphological and/or immunological presence of placental cells. We conclude that the transcervical recovery of fetal cells, while promising, requires considerable additional effort being expended in further research and development, particular in the sampling procedure.
Ge MOS characteristics with CVD HfO/sub 2/ gate dielectrics and TaN gate electrode

In this paper, we report for the first time Ge MOS characteristics with ultra thin rapid thermal CVD HfO/sub 2/ gate dielectrics and TaN gate electrode. Using the newly developed pre-gate cleaning and NH/sub 3/-based Ge surface passivation, the TaN/HfO/sub 2//Ge gate stack with EOT of 12.9 /spl Aring/ exhibits excellent leakage current density of 6 mA/cm/sup 2/ @Vg=1V and interface state density (D/sub it/) of 8/spl times/10/sup 10//cm/sup 2/-eV. Both D/sub it/ and CV hysteresis of Ge MOS are improved significantly with NH/sub 3/ surface treatment. We also study the effects of post-deposition anneal and investigate the conduction mechanism of TaN/HfO/sub 2//Ge gate stack.
The significance of relative dose intensity in adjuvant chemotherapy of pancreatic ductal adenocarcinoma—including the analysis of clinicopathological factors influencing relative dose intensity

AbstractRecently, it has been reported that the relative dose intensity (RDI) of adjuvant chemotherapy (AC) influences survival in various cancers, but there are very few reports about RDI in pancreatic ductal adenocarcinoma (PDAC). The optimal timing for initiation of AC for PDAC also remains unknown. The aim of this study was to identify the significance of RDI and the time interval between surgery and initiation of AC on survival of patients with PDAC. Clinicopathological factors that affect RDI were also investigated.A total of 311 consecutive PDAC patients who underwent curative resection between May 2005 and January 2015 were enrolled. Patients who underwent neoadjuvant chemoradiation, had UICC stage IV disease, or had early recurrences within 6 months were excluded, and the remaining 168 cases were analyzed.Patients with RDIs ≥80% (n = 79) showed significantly better overall survival (OS) compared to patients with RDIs <80% (n = 55) (median survival time (MST): 45.6 months, 26.0 months, P < 0.001). Patients with no AC (n = 34) showed the worst OS (MST: 20.8 months). Whether the AC was initiated earlier or later than 8 weeks after surgery did not influence survival, either in patients with RDIs ≥80% (P = 0.79) or in those with <80% (P = 0.73). Patients in the S-1 monotherapy group (n = 49) showed significantly better OS than patients in the gemcitabine monotherapy group (n = 51) (MST: 95.0 months, 26.0 months, respectively; P = 0.001). Univariate analysis conducted after adjusting for the chemotherapeutic drug used identified several prognostic factors; male gender (P = 0.01), intraoperative blood transfusion (P = 0.005), lymph node metastasis (P = 0.03), and postoperative WBC count (P = 0.03). Multivariate analysis identified intra-plus postoperative blood transfusion (P = 0.002) and high postoperative platelet-to-lymphocyte ratios (PLR) (P = 0.04) as independent predictors of poor RDI.Efforts to maintain RDI had a greater impact on survival than the struggle to start AC early after surgery. Intra-plus postoperative blood transfusion and a high postoperative PLR could be predictive markers of reduced RDI in AC of PDAC patients. Avoidance of perioperative blood transfusions where possible and nutritional support during the perioperative period could maintain adequate RDI and may lead to improved long-term outcome.
Subaru Telescope Observations of Deep Impact

The impact cratering process on a comet is controversial but holds the key for interpreting observations of the Deep Impact collision with comet 9P/Tempel 1. Mid-infrared data from the Cooled Mid-Infrared Camera and Spectrometer (COMICS) of the Subaru Telescope indicate that the large-scale dust plume ejected by the impact contained a large mass (∼106 kilograms) of dust and formed two wings approximately ±45° from the symmetric center, both consistent with gravity as the primary control on the impact and its immediate aftermath. The dust distribution in the inner part of the plume, however, is inconsistent with a pure gravity control and implies that evaporation and expansion of volatiles accelerated dust.
FIDA : Face Recognition using Descriptive Input Semantics

Generic face recognition systems identify a subject by comparing the subject’s image to images in an existing face database[11]. These systems are very useful in forensics for criminal identification[7] and in security for biometric authentication[8], but are constrained by the availability and quality of subject images[1]. In this paper, we propose a novel system, FIDA, that uses descriptive nonvisual human input of facial features to perform face recognition without the need for a reference image for comparison. FIDA maps images in an existing database to a fourteen dimensional descriptive feature space using softmax regression, and compares input feature descriptions to images in feature space. FIDA clusters database images in feature space using feature-weighted K-Means clustering[4] to offer computational speedup while searching feature space for matching images.
NuSTAR OBSERVATIONS OF THE MAGNETAR 1E 2259+586

We report on new broad band spectral and temporal observations of the magnetar 1E 2259+586, which is located in the supernova remnant CTB 109. Our data were obtained simultaneously with the Nuclear Spectroscopic Telescope Array (NuSTAR) and Swift, and cover the energy range from 0.5–79 keV. We present pulse profiles in various energy bands and compare them to previous RXTE results. The NuSTAR data show pulsations above 20 keV for the first time and we report evidence that one of the pulses in the double-peaked pulse profile shifts position with energy. The pulsed fraction of the magnetar is shown to increase strongly with energy. Our spectral analysis reveals that the soft X-ray spectrum is well characterized by an absorbed double blackbody or blackbody plus power-law model in agreement with previous reports. Our new hard X-ray data, however, suggest that an additional component, such as a power law, is needed to describe the NuSTAR and Swift spectrum. We also fit the data with the recently developed coronal outflow model by Beloborodov for hard X-ray emission from magnetars. The outflow from a ring on the magnetar surface is statistically preferred over outflow from a polar cap.