Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Four Different Treatment Options in the Management of Acute Conversion Disorder

Objective: Patients with conversion disorder may be seen by different specialists in various clinics and emergency situations. However, there are not sufficient studies on the most effective treatment for this disabling illness. Methods: In a clinical trial, we compared four treatment strategies; muscle relaxation, suggestion, hypnosis and intravenous diazepam infusion, in 80 patients with acute conversion disorder. Speed of recovery and number of the recurrences in a month following different treatment options were compared among groups. Results: Recovery was significantly quicker with muscle relaxation compared to hypnosis and diazepam infusion. In patients with comorbidity of major depressive disorder, recovery was even faster. There was no statistically significant differences in the number of remissions or relapses among the four groups. Conclusion: All the four different treatment strategies brought about significant recovery. However, after treating patients with muscle relaxation, recovery was faster compared to other treatment methods.
Immediate peri‐operative memory

Background: Information about anterograde and retrograde amnesias in the immediate peri‐operative period is scarce. During this period, assessment of memory for real‐life events is also rare. We hypothesized that there would be both anterograde and retrograde amnesias and memory for peri‐operative events would be better than for verbal memory.
Capacitive indoor positioning and contact sensing for activity recognition in smart homes

In smart homes, unobtrusive monitoring of user position and activity are important but challenging tasks. With the current state of technology, this task is especially hard to carry out in private areas where video surveillance is considered undesirable or even offensive. Even though some alternative methods for passive and unobtrusive monitoring of people have been proposed in the past, we still do not have a simple method that could be used to measure user position and activities as a single practical solution. To fulfill this need, this paper presents a single privacy-preserving method to measure user position and activity which can easily be adapted to measure the subject's height and posture as well. The system proposed in this paper can locate a person at floor level and monitor the subject's interaction with common household items such as a bed, sofa, table or refrigerator. The measurement method is based on the conductivity of the human body and on capacitive coupling of low-frequency signals between electrodes embedded in the floor and the in the environment. A test system was built for the TUT Smart Home and was evaluated with multiple test subjects, including a two-week-long living test to show the system's potential in long-term monitoring applications. The results show that a standing person can be positioned to within either 7 or 11-cm accuracy at a 90% confidence level using 30 × 30-cm and 60 × 60-cm-sized transmitting floor electrodes, respectively. For people walking, the respective accuracies are 17 and 33 cm. According to the long-term test results, the interactions with the environment were detected accurately. All the test data from this long-term living test, including the person's position, contact with common household items as well as the user annotations, have been made public and are available for download.
Plasma sodium and subclinical left atrial enlargement in chronic kidney disease.

BACKGROUND Left atrial enlargement (LAE) reflects diastolic dysfunction and predicts mortality in end-stage renal disease patients. However, little is known of its prevalence and factors associated with subclinical LAE in earlier stages of chronic kidney disease (CKD). METHODS We conducted a prospective, cross-sectional study in 261 Stage 3-5 non-dialysis CKD patients without symptomatic cardiovascular disease with two-dimensional echocardiography performed to estimate left atrial volume index and other cardiac parameters. RESULTS One hundred and nine (41.8%) patients had LAE. Mild and moderate/severe LAEs were observed in 22.9 and 41.3% of patients with left ventricular (LV) hypertrophy (n = 109) versus 13.2 and 12.5% of patients with no LV hypertrophy (n = 152), respectively (P < 0.001). On univariate analysis, plasma sodium concentration showed a significant association with LAE [odds ratio (OR) 1.22, 95% confidence interval (95% CI) 1.09-1.37; P = 0.001]. In the stepwise multiple logistic regression, plasma sodium concentration emerged as one of the most significant factors associated with LAE (adjusted OR 1.29, 95% CI 1.14-1.47; P < 0.001]. Its significance was well maintained (adjusted OR 1.23, 95% CI 1.07-1.43; P = 0.005) when including LV mass and volume index and N-terminal pro-brain natriuretic peptide in the model, while blood haemoglobin and systolic blood pressure were displaced. CONCLUSIONS This study for the first time alerted to a very high prevalence of subclinical LAE and reported a strong novel, independent relationship between plasma sodium concentration and subclinical LAE in Stage 3-5 CKD patients. Longitudinal studies are needed to establish causality between high plasma sodium concentration and LAE and their usefulness as therapeutic targets in CKD.
Channel Assignments in Wireless Networks with Time-Varying Traffic Behaviors

Many of the models used to analyze the performance of wireless networks assume stationary traffic behaviors where the average state-changing event times are constant. Various analysis of real traffic traces have shown that such behaviors in mobile wireless networks vary periodically during the day and night. Other systems also exhibit a similar behavior. A better analysis of the network's performance can be achieved by assuming the traffic behaviors to be non-stationary in such systems. In this paper, a multi-server queueing system is presented where the arrival and service probabilities in each time slot are time-dependent and periodic. The model can be applied for computing the optimal assignment of channels that adheres to certain performance level requirements.
Dopamine–Glutamate Interactions Controlling Prefrontal Cortical Pyramidal Cell Excitability Involve Multiple Signaling Mechanisms

Although the importance of dopamine (DA) for prefrontal cortical (PFC) cognitive functions is widely recognized, the nature of DA actions in the PFC remains controversial. A critical component in DA actions is its modulation of glutamate transmission, which can be different when specific receptors are activated. To obtain a clear picture of cellular mechanisms involved in these interactions, we studied the effects of DA–glutamate coactivation on pyramidal cell excitability in brain slices obtained from developmentally mature rats using whole-cell patch-clamp recordings. Bath application of NMDA, AMPA, and the D1 agonist SKF38393 induced concentration-dependent excitability increases, whereas bath application of the D2 receptor agonist quinpirole induced a concentration-dependent excitability decrease. The NMDA-mediated response was potentiated by SKF38393. This NMDA–D1 synergism required postsynaptic intracellular Ca2+ and protein kinase A (PKA) and was independent of membrane depolarization. On the other hand, the excitatory effects of both NMDA and AMPA were attenuated by a D2 agonist. Surprisingly, the D2–NMDA interaction was also blocked by the GABAA antagonists bicuculline and picrotoxin, suggesting that the inhibitory action of D2 receptors on NMDA-induced responses in the PFC may be mediated by GABAergic interneurons. In contrast, the D2–AMPA interaction involves inhibition of PKA and activation of phospholipase lipase C–IP3 and intracellular Ca2+ at a postsynaptic level. Thus, the modulatory actions of D1 and D2 receptors on PFC pyramidal cell excitability are mediated by multiple intracellular mechanisms and by activation of GABAA receptors, depending on the glutamate receptor subtypes involved.
The `not guilty verdict'

Asperger syndrome is a relatively new diagnostic classification. A number of factors make receiving a diagnosis of Asperger syndrome in adulthood a unique experience. This study used a phenomenological approach to examine the experiences of 10 adults receiving such a diagnosis. Results suggested that six major themes were associated with receiving a diagnosis of Asperger syndrome. Individuals discussed their negative life experiences and their experience of services prior to diagnosis, which led to individuals holding certain beliefs about the symptoms of Asperger syndrome. These beliefs had an effect on the formation of each individual's perceived self-identity. Participants made links between how they felt when they received the diagnosis and their current beliefs about both their `symptoms' and themselves. Finally, participants highlighted the importance of the societal view of Asperger syndrome. The implications of these findings are reappraised in the context of previous research and the wider literature on identity formation.
Spectroscopy of Rocks and Minerals , and Principles of Spectroscopy

Spectroscopy is the study of light as a function of wavelength that has been emitted, reflected, or scattered from a solid, liquid, or gas. In this chapter I discuss primarily the spectroscopy of minerals, but the principles apply to any material. No single chapter can cover this topic adequately, and one could argue, not even a single book. Thus, in some ways, this chapter may fall short of some reader’s expectations. This chapter constitutes an overview of what is already known (some of which may be covered better in other reviews) and some of the practical lessons of spectroscopy, some of which have been in use by spectroscopists as common knowledge but have not necessarily been published previously in detail. See Farmer (1974), Adams (1975), Hunt (1977, 1982), Clark and Roush (1984), Clark et al. (1990a), Gaffey et al. (1993), Salisbury (1993), and references in those papers for more details.
Selected anionic and cationic surface active agents: case study on the Kłodnica sediments

Abstract Surface active agents (surfactants) are a group of chemical compounds, which are used as ingredients of detergents, cleaning products, cosmetics and functional products. After use, wastes containing surfactants or their degradation products are discharged to wastewater treatment plants or directly into surface waters. Due to their specific properties of SAAs, compounds are able to migrate between different environmental compartments such as soil, sediment, water or even living organisms and accumulate there. Surfactants can have a harmful effect on living organisms. They can connect with bioactive molecules and modify their function. Additionally, they have the ability to migrate into cells and cause their damage or death. For these reasons investigation of individual surfactants should be conducted. The presented research has been undertaken to obtain information about SAA contamination of sediment from the River Kłodnica catchment caused by selected anionic (linear alkylbenzene sulfonates (LAS C10-C13)) and cationic (alkylbenzyldimethylammonium (BDMA-C12-16), alkyl trimethyl ammonium (DTMA), hexadecyl piridinium chloride (HP) chlorides) surfactants. This river flows through an area of the Upper Silesia Industrial Region where various companies and other institutions (e.g. coal mining, power plants, metallurgy, hospitals) are located. To determine their concentration the following analytical tools have been applied: accelerated solvent extraction– solid phase extraction – high performance liquid chromatography – UV-Vis (anionic SAAs) and conductivity (cationic SAAs) detectors. In all sediments anionic SAAs have been detected. The concentrations of HTMA and BDMA-C16 in tested samples were higher than other cationic analytes. Generally, levels of surfactants with longer alkyl chains were higher and this observation can confirm their higher susceptibility to sorption on solid surfaces.
Management and Survival of Meconium Ileus A 30‐year Review

Cystic fibrosis patients born with meconium ileus (MI) have had an improved outcome over the last three decades. The authors reviewed the impact of surgical management and long-term nutritional care on the survival of patients with MI. Of the 59 cases of MI seen from 1959 to 1989, 48 cases were managed operatively using either the Bishop-Koop ileostomy (BK), the Mikulicz il-eostomy, primary resection and anastomosis (RA), or ileotomy. Six-month survival of MI has improved from 37% to 100%. Nonoperative cases (n = 11) had 100% long-term survival. The RA survivors required less late operative intervention (20%) as compared with other surgical patients (81%). A comparison of serial growth percentiles of CF patients with MI with those of their non-Mi CF peers showed similar long-term decreases. These data confirm: (1) There is an improved survival for MI independent of the surgical procedure; (2) The BK ileostomy is an effective and time-tested MI treatment; (3) Primary resection and anastomosis in selected cases may have a lower surgical morbidity rate; and (4) Meconium ileus does not adversely affect the long-term nutritional outcome of CF patients.
On Route Lifetime in Multihop Mobile Ad Hoc Networks

One wireless network architecture that has received a lot of attention recently is the mobile ad hoc network (MANET). It is attractive because the network can be quickly deployed without the infrastructure of base stations. One main feature of MANET is that mobile hosts may communicate with each other through a sequence of wireless links (i.e., in a multihop manner). While many routing protocols have been proposed for MANET by considering criteria such as length, quality, bandwidth, and signal strength [S. Agarwal et al., 2000], [D.B. Johnson et al., 2000], [R. Dube et al., Feb. 1997], [Z. Haas and M. Pearlman, 2000], [M. Jiang et al., 1998], [C. Perkins and P. Bhagwat, Sept. 1994], the issue of route lifetime has not been addressed formally. This paper presents a formal model to predict the lifetime of a routing path based on the random walk model. Route lifetime is derived based on a probabilistic model. Through such investigation, we hope to provide further insight into issues such as route selection, route maintenance, and network scalability related to MANETs.
Medication prescribing errors in a public teaching hospital in India: A prospective study

Background To prevent medication errors in prescribing, one needs to know their types and relative occurrence. Such errors are a great cause of concern as they have the potential to cause patient harm. The aim of this study was to determine the nature and types of medication prescribing errors in an Indian setting. Methods The medication errors were analyzed in a prospective observational study conducted in 3 medical wards of a public teaching hospital in India. The medication errors were analyzed by means of Micromedex Drug-Reax database. Results Out of 312 patients, only 304 were included in the study. Of the 304 cases, 103 (34%) cases had at least one error. The total number of errors found was 157. The drug-drug interactions were the most frequently (68.2%) occurring type of error, which was followed by incorrect dosing interval (12%) and dosing errors (9.5%). The medication classes involved most were antimicrobial agents (29.4%), cardiovascular agents (15.4%), GI agents (8.6%) and CNS agents (8.2%). The moderate errors contributed maximum (61.8%) to the total errors when compared to the major (25.5%) and minor (12.7%) errors. The results showed that the number of errors increases with age and number of medicines prescribed. Conclusion The results point to the establishment of medication error reporting at each hospital and to share the data with other hospitals. The role of clinical pharmacist in this situation appears to be a strong intervention; and the clinical pharmacist, initially, could confine to identification of the medication errors.
Ultrasound video analysis for understanding infant breastfeeding

While it has been widely proved that breastfeeding is the healthiest feeding option for a baby and its mother, the mechanisms by which a baby removes milk from the breast are still not completely known. Partly this is due to the lack of tools to analyze images of the infant oral cavity during feeding automatically and quantitatively. In this paper we propose two methods for analyzing ultrasound videos to automatically detect relevant events such sucking and swallowing of milk and to discriminate different types of tongue action during milk removal. The proposed algorithms provide, for the first time, quantitative indications of the type of activities carried out during breastfeeding by the baby, promising unprecedented advancements in the field.
Interface surfaces for protein-protein complexes

Protein-protein interactions, which form the basis for most cellular processes, result in the formation of protein interfaces. Believing that the local shape of proteins is crucial, we take a geometric approach and present a definition of an interface surface formed by two or more proteins. We also present an algorithm and study the geometric and topological properties of these surfaces, thus paving the way for future biochemical studies of protein-protein interactions.
Practice guideline for psychiatric evaluation of adults. American Psychiatric Association.

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YM-359445, an Orally Bioavailable Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor, Has Highly Potent Antitumor Activity against Established Tumors

Purpose: The vascular endothelial growth factor receptor-2 (VEGFR2) tyrosine kinase has been implicated in the pathologic angiogenesis associated with tumor growth. YM-359445 was a (3Z)-3-quinolin-2(1H)-ylidene-1,3-dihydro-2H-indol-2-one derivative found while screening based on the inhibition of VEGFR2 tyrosine kinase. The aim of this study was to analyze the efficacy of this compound both in vitro and in vivo. Experimental Design: We tested the effects of YM-359445 on VEGFR2 tyrosine kinase activity, cell proliferation, and angiogenesis. The antitumor activity of YM-359445 was also tested in nude mice bearing various established tumors and compared with other VEGFR2 tyrosine kinase inhibitors (ZD6474, CP-547632, CGP79787, SU11248, and AZD2171), a cytotoxic agent (paclitaxel), and an epidermal growth factor receptor tyrosine kinase inhibitor (gefitinib). Results: The IC50 of YM-359445 for VEGFR2 tyrosine kinase was 0.0085 μmol/L. In human vascular endothelial cells, the compound inhibited VEGF-dependent proliferation, VEGFR2 autophosphorylation, and sprout formation at concentrations of 0.001 to 0.003 μmol/L. These concentrations had no direct cytotoxic effect on cancer cells. In mice bearing various established tumors, including paclitaxel-resistant tumors, once daily oral administration of YM-359445 at doses of 0.5 to 4 mg/kg not only inhibited tumor growth but also reduced its vasculature. YM-359445 had greater antitumor activity than other VEGFR2 tyrosine kinase inhibitors. Moreover, in human lung cancer A549 xenografts, YM-359445 markedly regressed the tumors (73%) at a dose of 4 mg/kg, whereas gefitinib caused no regression even at 100 mg/kg. Conclusion: Our results show that YM-359445 is more potent than orally bioavailable VEGFR2 tyrosine kinase inhibitors, which leads to great expectations for clinical applicability.
A Survey: Digital Image Watermarking Techniques

Multimedia security is extremely significant concern for the internet technology because of the ease of the duplication, distribution and manipulation of the multimedia data. The digital watermarking is a field of information hiding which hide the crucial information in the original data for protection illegal duplication and distribution of multimedia data. This paper presents a survey on the existing digital image watermarking techniques. The results of various digital image watermarking techniques have been compared on the basis of outputs. In the digital watermarking the secret information are implanted into the original data for protecting the ownership rights of the multimedia data. The image watermarking techniques may divide on the basis of domain like spatial domain or transform domain or on the basis of wavelets. The spatial domain techniques directly work on the pixels and the frequency domain works on the transform coefficients of the image. This survey elaborates the most important methods of spatial domain and transform domain and focuses the merits and demerits of these techniques.
Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR

M2 Out of the Envelope The M2 protein from influenza A virus forms an acid-activated tetrameric proton channel in the viral envelope and is essential for viral replication. Two manuscripts shed light on the functional mechanism of this channel. Sharma et al. (p. 509; see the Perspective by Fiorin et al.) determined the structure of the conductance domain in a lipid bilayer and propose that a histidine and tryptophan from each monomer form a cluster that guides protons through the channel in a mechanism that involves forming and breaking hydrogen bonds between adjacent pairs of histidines. Hu et al. (p. 505; see the Perspective by Fiorin et al.) focused on the structure and dynamics of the proton-selective histidine at high and low pH, proposing that proton conduction involves histidine deprotonation and reprotonation. Histidine side-chain dynamics regulate proton conduction in an influenza proton channel. The M2 protein of influenza viruses forms an acid-activated tetrameric proton channel. We used solid-state nuclear magnetic resonance spectroscopy to determine the structure and functional dynamics of the pH-sensing and proton-selective histidine-37 in M2 bound to a cholesterol-containing virus-envelope-mimetic membrane so as to better understand the proton conduction mechanism. In the high-pH closed state, the four histidines form an edge-face π-stacked structure, preventing the formation of a hydrogen-bonded water chain to conduct protons. In the low-pH conducting state, the imidazoliums hydrogen-bond extensively with water and undergo microsecond ring reorientations with an energy barrier greater than 59 kilojoules per mole. This barrier is consistent with the temperature dependence of proton conductivity, suggesting that histidine-37 dynamically shuttles protons into the virion. We propose a proton conduction mechanism in which ring-flip–assisted imidazole deprotonation is the rate-limiting step.