Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors that influence recurrent lumbar disc herniation.

INTRODUCTION The most common cause of poor outcome following lumbar disc surgery is recurrent herniation. Recurrence has been noted in 5% to 15% of patients with surgically treated primary lumbar disc herniation. There have been many studies designed to determine the risk factors for recurrent lumbar disc herniation. In this study, we retrospectively analysed the influence of disc degeneration, endplate changes, surgical technique, and patient's clinical characteristics on recurrent lumbar disc herniation. METHODS Patients who underwent primary single-level L4-L5 lumbar discectomy and who were reoperated on for recurrent L4-L5 disc herniation were retrospectively reviewed. All these operations were performed between August 2004 and September 2009 at the Neurosurgery Department of Ataturk Education and Research Hospital in Ankara, Turkey. RESULTS During the study period, 126 patients were reviewed, with 101 patients underwent primary single-level L4-L5 lumbar discectomy and 25 patients were reoperated on for recurrent L4-L5 disc herniation. Preoperative higher intervertebral disc height (P<0.001) and higher body mass index (P=0.042) might be risk factors for recurrence. Modic endplate changes were statistically significantly greater in the recurrent group than in the non-recurrent group (P=0.032). CONCLUSION Our study suggests that patients who had recurrent lumbar disc herniation had preoperative higher disc height and higher body mass index. Modic endplate changes had a higher tendency for recurrence of lumbar disc herniation. Well-planned and well-conducted large-scale prospective cohort studies are needed to confirm this and enable convenient treatment modalities to prevent recurrent disc pathology.
The structure of human CD23 and its interactions with IgE and CD21

The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcɛRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response. We have determined the three-dimensional structure of the C-type lectin domain of CD23 in solution by nuclear magnetic resonance spectroscopy. An analysis of concentration-dependent chemical shift perturbations have allowed us to identify the residues engaged in self-association to the trimeric state, whereas ligand-induced changes have defined the binding sites for IgE and CD21. The results further reveal that CD23 can bind both ligands simultaneously. Despite the C-type lectin domain structure, none of the interactions require calcium. We also find that IgE and CD23 can interact to form high molecular mass multimeric complexes. The interactions that we have described provide a solution to the paradox that CD23 is involved in both up- and down-regulation of IgE and provide a structural basis for the development of inhibitors of allergic disease.
Symptoms of posttraumatic stress disorder and depression among children in tsunami-affected areas in southern Thailand.

CONTEXT On December 26, 2004, an undersea earthquake occurred off the northwestern coast of Sumatra, Indonesia. The tsunami that followed severely impacted all 6 southwestern provinces of Thailand, where approximately 20,000 children were directly affected. OBJECTIVE To assess trauma experiences and the prevalence of symptoms of posttraumatic stress disorder (PTSD) and depression among children in tsunami-affected provinces in southern Thailand. DESIGN, SETTING, AND PARTICIPANTS Population-based mental health surveys were conducted among children aged 7 to 14 years in Phang Nga, Phuket, and Krabi provinces from February 15-22, 2005 (2 months posttsunami), and September 7-12, 2005 (9 months posttsunami). MAIN OUTCOME MEASURES Trauma experiences and symptoms of PTSD and depression as measured by a tsunami-modified version of the PsySTART Rapid Triage System, the UCLA PTSD Reaction Index, and the Birleson Depression Self-Rating Scale. RESULTS A total of 371 children (167 displaced and living in camps, 99 not displaced from villages affected by the tsunami, and 105 not displaced from unaffected villages) participated in the first survey. The prevalence rates of PTSD symptoms were 13% among children living in camps, 11% among children from affected villages, and 6% among children from unaffected villages (camps vs unaffected villages, P = .25); for depression symptoms, the prevalence rates were 11%, 5%, and 8%, respectively (P = .39). In multivariate analysis of the first assessment, having had a delayed evacuation, having felt one's own or a family member's life to have been in danger, and having felt extreme panic or fear were significantly associated with PTSD symptoms. Older age and having felt that their own or a family member's life had been in danger were significantly associated with depression symptoms. In the follow-up survey, 72% (151/210) of children from Phang Nga participated. Prevalence rates of symptoms of PTSD and depression among these children did not decrease significantly over time. CONCLUSIONS This assessment documents the prevalence of mental health problems among children in tsunami-affected provinces in southern Thailand at 2 and 9 months posttsunami. Traumatic events experienced during the tsunami were significantly associated with symptoms of PTSD and depression. These data may be useful to target mental health services for children and may inform the design of these interventions.
Specificity of Stress‐Responsive Transcription Factors Nrf2, ATF4, and AP‐1

Cellular stress leads to an upregulation of gene transcription. We asked if there is a specificity in the activation of the stress‐responsive transcription factors Nrf2, ATF4, and AP‐1/c‐Jun, or if activation of these proteins is a redundant cellular answer toward extracellular stressors. Here, we show that oxidative stress, induced by stimulation of the cells with the oxidant arsenite, strongly activated gene transcription via the stress‐responsive element (StRE), while phorbol ester or tunicamycin, activators of AP‐1/c‐Jun or ATF4, respectively, activated AP‐1 or nutrient‐sensing response element‐mediated transcription. Preincubation of the cells with N‐acetyl‐cysteine or overexpression of thioredoxin selectively attenuated arsenite‐induced upregulation of StRE‐regulated transcription. Expression of either dominant‐negative or constitutively active mutants of Nrf2, ATF4, or c‐Jun confirmed that distinct transcription units are regulated by these transcription factors. Physiological stimuli involving the activation of either Gαq‐coupled designer receptors or the protein kinases c‐Jun N‐terminal protein kinase or p38 strongly stimulated transcription via AP‐1/c‐Jun, with minimal effects on Nrf2 or ATF4‐responsive promoters. Thus, activation of transcription by extracellular signaling molecules shows specificity at the level of the chemical nature of the signaling molecule, at the level of the intracellular transduction process, and at the level of signal‐responsive transcription factors. J. Cell. Biochem. 118: 127–140, 2017. © 2016 Wiley Periodicals, Inc.
Iterative Polite Water-Filling for Weighted Sum-Rate Maximization in iTree Networks

It is well known that in general, the traditional water-filling is far from optimal in networks. We recently found the long-sought network version of water-filling named polite water-filling that is optimal for a large class of MIMO networks called B-MAC networks, of which interference Tree (iTree) networks is a subset whose interference graphs have no directional loop. iTree networks is a natural extension of both broadcast channel (BC) and multiaccess channel (MAC) and possesses many desirable properties for further information theoretic study. Given the optimality of the polite water-filling, general purpose optimization algorithms for networks are no longer needed because they do not exploit the structure of the problems. Here, we demonstrate it through the weighted sum-rate maximization. The significance of the results is that the algorithm can be easily modified for general B-MAC networks with interference loops. It illustrates the properties of iTree networks and for the special cases of MAC and BC, replaces the current steepest ascent algorithms for finding the capacity regions. The fast convergence and high accuracy of the proposed algorithms are verified by simulation.
Threat of Copper, Zinc, Lead, and Cadmium in Alfalfa (Medicago scutellata) as Livestock Forage and Medicinal Plant

Background: Concentrations of 4 toxic metals, viz. Cd, Cu, Pb, and Zn in the soil and alfalfa samples collected from Borujerd, Iran, was determined. The capability of alfalfa to accumulate heavy metals from soils was assessed in terms of Biological Concentration Factor. Materials and Methods: The alfalfa and soil samples were collected from 20 different farms, including 13 wastewater-irrigated and seven underground-irrigated farms. After acid digestion, the samples were analyzed using atomic absorption spectrophotometer. Results: The levels of Cd, Pb, and Zn in the soils of wastewater-irrigated farms were higher than those from the groundwater-irrigated farms. With the exception of Cu, concentrations of heavy metals in the alfalfa crop were higher in wastewater-irrigated farms compared to well water. Also, in the case of BCF, both Cd and Cu values decreased with increasing metal concentration in soil. The order of BCF of heavy metals in alfalfa was in order of Cu>Cd>Zn>Pb in well water-irrigated and Zn>Cd>Cu>Pb in wastewater –irrigated samples. Discussion and Conclusions: The findings remarked that the levels of Cu, Cd, and Pb in alfalfa were exceeding the permissible levels suggested by the Joint FAO/WHO Expert Committee on Food Additives. These outcomes propose that the consumption of alfalfa plants is potentially threatening both animal and human health.
Predictors of readiness for oral rapid HIV testing by Chilean health care providers.

Objective This study identified the personal characteristics that affect Chilean health care providers' readiness to adopt HIV Oral Rapid Testing (ORT) in Chile as a new clinical evidence-based practice (EBP). Methods Using a cross-sectional research design, the study sampled 150 nurses, midwives, and physicians employed at four clinics within the Pontifícia Universidad Católica de Chile Health Network in Santiago. Participants completed a self-administered survey asking about their demographic background, EBP attitudes and experience, personal beliefs related to HIV, the importance of HIV testing, and perceived self-comfort in performing a rapid HIV test. Results Of the participants, 90% believed that incorporating ORT would make a positive difference in their practice and said that they would be willing to adopt the technology for that reason. Nonetheless, the providers reported a mean "readiness to implement ORT" score of 15.1 out of a possible value of 20, suggesting only moderate self-perceived readiness to adopt the EBP. Education, beliefs about evidence-based practice, perceived comfort in performing ORT, and perceived importance of HIV testing explained 43.6% of the variance in readiness to adopt ORT. Conclusion The findings of this first ORT pre-implementation study in Chile can help guide policy makers and HIV stakeholders to prepare for and increase primary health care providers' readiness to successfully adopt this evidence-based technology. Successful adoption of ORT could increase Chile's capacity to reach HIV-vulnerable Chileans for testing and referral to care if infected, thus helping the country to reduce further transmission of the virus and its medical complications.
Effect of pre-pregnancy body mass index on respiratory-related neonatal outcomes in women undergoing elective cesarean prior to 39 weeks

Abstract Objective To examine the association between pre-pregnancy body mass index (BMI) and neonatal respiratory-related outcomes among women who underwent an elective cesarean section (CS). Methods A retrospective cohort study was conducted using the Centers for Disease Control and Prevention (CDC)’s 2009–2013 period linked birth/infant death dataset. Women who had elective CSs at term were categorized by their pre-pregnancy BMI as normal, overweight, obese or morbidly obese. Odds ratios (OR) and 95% confidence intervals (CIs), adjusted for baseline characteristics, were calculated using multivariate logistic regression to estimate the neonatal risks in relation to maternal pre-pregnancy BMI. Results Our cohort consisted of 717,080 women, of whom 39.9% had normal BMI, 27.0% were overweight, 25.7% obese and 7.4% morbidly obese. A dose-dependent relationship between maternal pre-pregnancy BMI and assisted ventilation was seen. Furthermore, infants born to morbidly obese women were at significantly increased risk for assisted ventilation over 6 h (OR 1.24, 95% CI 1.15–1.35) and admission to intensive care units (OR 1.17, 95% CI 1.13–1.21). Infant mortality rates were 4.2/1000 births for normal weight women, and 5.5/1000 births among the morbidly obese group (OR 1.43, 95% CI 1.25–1.64). Risk for adverse outcomes was increased with elective SC performed at earlier gestational age, and this effect was not modified by use of corticosteroids. Conclusion Overweight and obese women are at particularly greater risk of adverse newborn outcomes when elective CSs are done before 39 weeks. In these women, elective CSs should be delayed until 39 weeks, as corticosteroid use did not eliminate this association.
New methods for the assessment of Parkinson's disease (2005 to 2015): A systematic review

The past decade has witnessed a highly dynamic and growing expansion of novel methods aimed at improving the assessment of Parkinson's disease with technology (NAM‐PD) in laboratory, clinical, and home environments. However, the current state of NAM‐PD regarding their maturity, feasibility, and usefulness in assessing the main PD features has not been systematically evaluated.
Managing the Threat of Violence: Coping Strategies Among Juvenile Inmates

This article reports findings on violence, safety, and coping strategies from interviews conducted with 281 male youth incarcerated in California’s Division of Juvenile Justice (DJJ). Descriptive analyses revealed that youth report that violence is a common occurrence and that some locations, such as school or housing units, were particularly dangerous. Analysis of how youth avoid violence revealed three distinct precautionary or coping strategies. These three categories highlight a range of conflict management techniques from avoidance to aggression. Those youth who were younger, sex offenders, or newer to the facility used more passive avoidance techniques while gang members and those more active in violent misconduct used more aggressive techniques. A third group, those youth proactively navigating their interactions, had spent more time in their current institution and were marginally more likely to be adult court commitments. Intervention and policy implications of this study are also discussed.
Different expression patterns of sperm motility-related genes in testis of diploid and tetraploid cyprinid fish

Abstract Sperm motility is an important standard to measure the fertility of male. In our previous study, we found that the diploid spermatozoa from allotetraploid hybrid (4nAT) had longer durations of rapid and slow progressive motility than haploid spermatozoa from common carp (COC). In this study, to explore sperm motility-related molecular mechanisms, we compared the testis tissues transcriptomes from 2-year-old male COC and 4nAT. The RNA-seq data revealed that 2985 genes were differentially expressed between COC and 4nAT, including 2216 upregulated and 769 downregulated genes in 4nAT. Some differentially expressed genes, such as tubulin genes, dynein, axonemal, heavy chain(dnah) genes, mitogen-activated protein kinase(mapk) genes, tektin 4, FOX transcription factors, proteasome genes, and ubiquitin carboxyl-terminal hydrolase(uchl) genes, are involved in the regulation of cell division, flagellar and ciliary motility, gene transcription, cytoskeleton, energy metabolism, and the ubiquitin-proteasome system, suggesting that these genes were related to sperm motility of the 4nAT. We confirmed the differential expression of 12 such genes in 4nAT by quantitative PCR. By western blotting, we also confirmed increased expression of Uchl3 in 4nAT testis. In addition, we identified 1915 and 2551 predicted long noncoding RNA (lncRNA) transcripts from testis tissue transcriptomes of COC and 4nAT, respectively. Of these, 1575 lncRNAs were specifically expressed in 4nAT and 939 were specifically expressed in COC. This study provides insights into the transcriptome profile of testis tissues from diploid and tetraploid, which are useful for research on regulatorymechanisms behind sperm motility in male polyploidy. Summary Sentence Clues of variations in tetraploid testis are characterized by comparative transcriptome analysis between tetraploid hybrid and common carp.
Effect of Mixing Constituent toward Engineering Properties of POFA Cement-Based Aerated Concrete

Palm oil fuel ash (POFA) cement-based aerated concrete is a new type of lightweight concrete produced by integrating POFA, a by product of palm oil mill as a partial cement replacement in aerated concrete. This paper presents the effects of using a different character of mixing constituent such as size of sand, various amounts of gas foaming agent, and a range of superplasticizer content on the compressive strength and density of aerated concrete with and without POFA. POFA passing 300-µm sieve was ground until its fineness is 99% passing 45-µm sieve was incorporated as partial cement replacement. POFA cement-based aerated concrete was prepared by adding 20% of POFA by weight of cementitious materials. It was discovered that POFA cement-based aerated concrete continues to exhibit higher strength compared to ordinary portland cement aerated concrete throughout the experimental program. Thus, this newly found material could be used as environmental friendly construction material since it possess adequate strength fulfilling the requirement in ASTM allowing it to be used as nonload-bearing element yet having lower density below 1,000 kg/m3.
Motivation and challenge to capture both large-scale and local transport in next generation accretion theory

Accretion disc theory is less developed than stellar evolution theory although a similarly mature phenomenological picture is ultimately desired. While the interplay of theory and numerical simulations has amplified community awareness of the role of magnetic fields in angular momentum transport, there remains a long term challenge to incorporate the insights gained from simulations into improving practical models for comparison with observations. What has been learned from simulations that can lead to improvements beyond SS73 in practical models? Here, we emphasize the need to incorporate the role of non-local transport more precisely. To show where large-scale transport would fit into the theoretical framework and how it is currently missing, we review why the wonderfully practical approach of Shakura & Sunyaev (Astron. Astrophys., vol. 24, 1973, pp. 337–355, SS73) is necessarily a mean field theory, and one which does not include large-scale transport. Observations of coronae and jets, combined with the interpretation of results from shearing box simulations, of the magnetorotational instability (MRI) suggest that a significant fraction of disc transport is indeed non-local. We show that the Maxwell stresses in saturation are dominated by large-scale contributions and that the physics of MRI transport is not fully captured by a viscosity. We also clarify the standard physical interpretation of the MRI as it applies to shearing boxes. Computational limitations have so far focused most attention toward local simulations, but the next generation of global simulations should help to inform improved mean field theories. Mean field accretion theory and mean field dynamo theory should in fact be unified into a single theory that predicts the time evolution of spectra and luminosity from separate disc, corona and outflow contributions. Finally, we note that any mean field theory, including that of SS73, has a finite predictive precision that needs to be quantified when comparing the predictions to observations.
Trial-by-Trial Fluctuations in the Event-Related Electroencephalogram Reflect Dynamic Changes in the Degree of Surprise

The P300 component of the human event-related brain potential has often been linked to the processing of rare, surprising events. However, the formal computational processes underlying the generation of the P300 are not well known. Here, we formulate a simple model of trial-by-trial learning of stimulus probabilities based on Information Theory. Specifically, we modeled the surprise associated with the occurrence of a visual stimulus to provide a formal quantification of the “subjective probability” associated with an event. Subjects performed a choice reaction time task, while we recorded their brain responses using electroencephalography (EEG). In each of 12 blocks, the probabilities of stimulus occurrence were changed, thereby creating sequences of trials with low, medium, and high predictability. Trial-by-trial variations in the P300 component were best explained by a model of stimulus-bound surprise. This model accounted for the data better than a categorical model that parametrically encoded the stimulus identity, or an alternative model of surprise based on the Kullback–Leibler divergence. The present data demonstrate that trial-by-trial changes in P300 can be explained by predictions made by an ideal observer keeping track of the probabilities of possible events. This provides evidence for theories proposing a direct link between the P300 component and the processing of surprising events. Furthermore, this study demonstrates how model-based analyses can be used to explain significant proportions of the trial-by-trial changes in human event-related EEG responses.
Early Life Pb Exposure and its Effect on Later Life Retinal Degeneration

The study presents the longitudinal effect of early life lead exposure on retinal ischemia. Swiss albino mice were exposed to lead acetate at two different timepoints viz. postnatal day 1–20 and at 7th week of age. These mice were then followed till 10 week of age and subjected to retinal ischemia. Retinal ischemia was induced using pterygopalatine artery ligation. The effect of prior lead exposure on ischemic insult was determined using various histological and molecular parameters. Although toxic effects of Pb are well reported, but the results in this study showed not much significant effect of early life Pb exposure on later life retinal degeneration. While retinal thickness was decreased in surgery group and 7th week Pb exposed group, PND Pb exposed mice showed retinal thickness comparable to normal control. There was no difference in TUNEL positive cells in Pb exposed group when compared to surgery group. The molecular studies revealed overexpression of BDNF and GFAP in PND Pb exposed mice reflecting more injury and inflammation. The combined results revealed that Pb exposure have mild effect on overall susceptibility to retinal damage in later life. The Pb may exert its toxic effects at longer duration and thus the toxic effects may be mapped at longer timepoints. The study provides a new dimension to the already well known toxic effects of lead which needs to be further explored. J. Cell. Biochem. 118: 3213–3224, 2017. © 2017 Wiley Periodicals, Inc.