Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Information Overload and Contribution Overload on Continued Usage of Electronic Knowledge Repositories

In the modern competitive organizational environment, more and more organizations are implementing knowledge management initiatives to achieve strategic advantages. One such initiative involves the implementation of electronic knowledge repositories (EKR). EKR implementation frequently results in a rapid increase in the quantity of information that must be processed daily by employees. This raises concerns about information overload (IO), and this is particularly true in relation to modern EKRs that use distributive technology. Furthermore, employees can also suffer from contribution overload (CO) because they can fulfill the functions of both knowledge seekers and knowledge contributors. This study employs the cognitive dissonance theory to determine whether IO and CO affect employees' willingness to use EKRs. The results from 144 survey respondents provide the first empirical evidence that contribution overload exerts a direct and significant negative effect on the intention to continue using EKR, whereas information overload exerts an indirect and significant negative effect on the intention to continue using EKR by altering perceived usefulness and satisfaction with the system.
Emotions shape memory suppression in trait anxiety

The question that motivated this study was to investigate the relation between trait anxiety, emotions and memory control. To this aim, memory suppression was explored in high and low trait anxiety individuals with the Think/No-think paradigm. After learning associations between neutral words and emotional scenes (negative, positive, and neutral), participants were shown a word and were requested either to think about the associated scene or to block it out from mind. Finally, in a test phase, participants were again shown each word and asked to recall the paired scene. The results show that memory control is influenced by high trait anxiety and emotions. Low trait anxiety individuals showed a memory suppression effect, whereas there was a lack of memory suppression in high trait anxious individuals, especially for emotionally negative scenes. Thus, we suggest that individuals with anxiety may have difficulty exerting cognitive control over memories with a negative valence. These findings provide evidence that memory suppression can be impaired by anxiety thus highlighting the crucial relation between cognitive control, emotions, and individual differences in regulating emotions.
Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics

Many smoking‐related phenotypes are substantially heritable. One genome scan of nicotine dependence (ND) has been published and several others are in progress and should be completed in the next 5 years. The goal of this hypothesis‐generating study was two‐fold. First, we present further analyses of our genome scan data for ND published by Straub et al. [ 1999 : Mol Psychiatry 4:129–144] (PMID: 10208445). Second, we used the method described by Cox et al. [ 1999 : Nat Genet 21:213–215] (PMID: 9988276) to search for epistatic loci across the markers used in the genome scan. The overall results of the genome scan nearly reached the rigorous Lander and Kruglyak [ 1995 : Nat Genet 11:241–247] criteria for “significant” linkage with the best findings on chromosomes 10 and 2. We then looked for correspondence between genes located in the 10 regions implicated in affected sibling pair (ASP) and epistatic linkage analyses with a list of genes suggested by microarray studies of experimental nicotine exposure and candidate genes from the literature. We found correspondence between linkage and microarray/candidate gene studies for genes involved with the mitogen‐activated protein kinase (MAPK) signaling system, nuclear factor kappa B (NFKB) complex, neuropeptide Y (NPY) neurotransmission, a nicotinic receptor subunit (CHRNA2), the vesicular monoamine transporter (SLC18A2), genes in pathways implicated in human anxiety (HTR7, TDO2, and the endozepine‐related protein precursor, DKFZP434A2417), and the µ1‐opioid receptor (OPRM1). Although the hypotheses resulting from these linkage and bioinformatic analyses are plausible and intriguing, their ultimate worth depends on replication in additional linkage samples and in future experimental studies. © 2003 Wiley‐Liss, Inc.
On the Uniqueness of Loopy Belief Propagation Fixed Points

We derive sufficient conditions for the uniqueness of loopy belief propagation fixed points. These conditions depend on both the structure of the graph and the strength of the potentials and naturally extend those for convexity of the Bethe free energy. We compare them with (a strengthened version of) conditions derived elsewhere for pairwise potentials. We discuss possible implications for convergent algorithms, as well as for other approximate free energies.
[Pathogenic and clinical presentation of bullous rash in hand, foot and mouth disease].

OBJECTIVE To investigate the pathogenic and clinical presentation and laboratory tests of bullous rash in hand, foot and mouth disease (HFMD) in Xi'an from January 2013 to December 2014 by retrospective analysis. METHOD A total of 224 specimens were collected from clinically diagnosed HFMD cases who were characterized by widespread mucocutaneous bullous reactions in Xi'an Children's Hospital from January 2013 to December 2014, the identification and subtyping of the isolates were conducted with real-time fluorescent quantitative RT-PCR. A retrospective analysis was performed to analyze the clinical presentation, laboratory tests and late follow-up problems of the HFMD. RESULT In the clinically diagnosed HFMD cases who were characterized by widespread mucocutaneous bullous reactions, 207 were caused by coxsackievirus A6 (CA6), accounting for 92. 4% of all cases with bullous, 4 were caused by enterovirus 71 (EV71), accounting for 1.8%, 10 were caused by coxsackievirus A16 (CA16), accounting for 4. 5%; 4 cases were negative for these viruses. In the cases positive for intestinal virus-nucleic acid, 130 were male, 90 were female; male to female ratio was 1. 44: 1, 203 were <5 years old, accounting for 92. 3%. Leukocytosis was found in 75 cases (34. 1%); high-sensitivity C-reactive protein (hsCRP) increased in 200 cases (90. 9%); elevated myocardial enzyme CK-MB was found in 35 cases (15. 9%), alanine aminotransferase increased in 15 cases (6. 8%); 187 cases had fever (85. 0%). None of the cases had serious complications such as encephalitis or myocarditis. In the course of the critical phase bullous rash or large vesicle-like changes, obvious itching, and facial rash appeared. After the fluid in the bullae was absorbed or the bullae ruptured or became ulcerated, scar formation and large areas of exfoliation occurred, with no effusion on the newly formed epithelium in the base, without significant pigmentation on later follow-up. In the late follow up process, 52 cases in CA6-positive patients (25. 1%) developed onychomadesis within 2-4 weeks after onset, 1 to 8 nails, an average of 4. 3 fell off, new nails grew, the nail bed showed no structural abnormalities and hyperplasia after falling off, the surface was smooth, had no hypertrophy, left no sequelae. CONCLUSION The pathogen in HFMD characterized by widespread bullous reactions was mainly the CA6, this kind of HFMD was mainly mild type, with significant itching, later the bullae may have scar formation and skin exfoliation, in some cases onychomadesis may occur.
Using Bayes' Rule to Model Multisensory Enhancement in the Superior Colliculus

The deep layers of the superior colliculus (SC) integrate multisensory inputs and initiate an orienting response toward the source of stimulation (target). Multisensory enhancement, which occurs in the deep SC, is the augmentation of a neural response to sensory input of one modality by input of another modality. Multisensory enhancement appears to underlie the behavioral observation that an animal is more likely to orient toward weak stimuli if a stimulus of one modality is paired with a stimulus of another modality. Yet not all deep SC neurons are multisensory. Those that are exhibit the property of inverse effectiveness: combinations of weaker unimodal responses produce larger amounts of enhancement. We show that these neurophysiological findings support the hypothesis that deep SC neurons use their sensory inputs to compute the probability that a target is present. We model multimodal sensory inputs to the deep SC as random variables and cast the computation function in terms of Bayes' rule. Our analysis suggests that multisensory deep SC neurons are those that combine unimodal inputs that would be more uncertain by themselves. It also suggests that inverse effectiveness results because the increase in target probability due to the integration of multisensory inputs is larger when the unimodal responses are weaker.
Acute Rupture of the Tibialis Anterior Tendon: A Case Report

Acute rupture of tendons on the dorsum of the foot is rare and the diagnosis can be difficult. We present the case of a 51-year-old man who sustained an acute rupture of the tibialis anterior tendon. Pain about the medial aspect of the midfoot and ambulation with a steppage gait were the keys to formulating a correct diagnosis. The tendon was repaired primarily 10 days after injury. At his final follow-up examination 6 months after surgery, the patient was asymptomatic and ambulated with a normal gait.
8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.

STUDY OBJECTIVES Obstructive sleep apnea (OSA) is characterized by recurrent apnea during sleep that may compromise oxidative balance. Oxidative stress is increased in the blood and in the airways of OSA patients. DESIGN The aim of this study was to investigate whether oxidative stress is determined by nocturnal apneas and could be reduced by CPAP therapy, and whether there is a relation between local and systemic oxidative stress in these patients. PATIENTS AND METHODS Eighteen patients with OSA (13 men; mean [+/- SD] age, 48 +/- 3 years) and 12 healthy age-matched and weight-matched subjects (8 men; mean age, 46 +/- 7 years) were recruited. 8-Isoprostane was measured in exhaled breath condensate and blood by a specific enzyme immunoassay. MEASUREMENTS AND RESULTS Higher concentrations of 8-isoprostane were found in the morning exhaled condensate (9.5 +/- 1.9 pg/mL) and plasma (9.7 +/- 1.5 pg/mL) of OSA patients compared to healthy obese subjects (6.7 +/- 0.2 and 7.1 +/- 0.3 pg/mL, respectively; p < 0.0001). Elevated mean concentrations of exhaled 8-isoprostane were observed in the OSA patients at 8:00 AM (9.5 +/- 1.9 pg/mL) but not at 8:00 PM (7.6 +/- 0.8 pg/mL; p < 0.0005), and a significant reduction was seen after continuous positive airway pressure (CPAP) therapy (7.7 +/- 0.9 pg/mL; before treatment, 9.6 +/- 1.7 pg/mL; p < 0.005). A positive correlation was found between morning exhaled 8-isoprostane levels and the apnea-hypopnea index (r = 0.8; p < 0.0001), and 8-isoprostane levels and neck circumference (r = 0.6; p < 0.0001). CONCLUSIONS These findings suggest that systemic and local oxidative stress are increased in OSA patients, and that they are higher after nocturnal apnea and reduced by CPAP therapy.
Middle School Friendships and Academic Achievement in Early Adolescence: A Longitudinal Analysis

Early adolescence is a critical transition period for the maintenance of academic achievement. One factor that school systems often fail to take into account is the influence of friends on academic achievement during middle school. This study investigated the influence of friends’ characteristics on change in academic achievement from Grade 6 to Grade 8 and the role of students’ own characteristics as moderators of this relationship. The sample included 1,278 participants (698 girls). Linear regressions suggest that students with academically engaged friends may achieve to levels higher than expected in Grade 8. However, when considering the significant, negative influence of friends’ problem behavior, the role of friends’ school engagement became nonsignificant. Low-achieving girls who had high-achieving friends in Grade 6 had lower academic achievement than expected by Grade 8. In contrast, high-achieving girls seemed to benefit from having high-achieving friends. Implications for theory and prevention efforts targeting young adolescents are discussed.
Peptidergic innervation of the primate meibomian gland.

PURPOSE To localize and characterize nerves in primate meibomian glands using immunohistochemical staining for neuropeptides and neuronal enzymes. METHODS Upper eyelids were obtained from seven rhesus monkeys (Macaca mulatta) and one cynomolgous monkey (Macaca fascicularis). The tissues were fixed either by immersion in Zamboni's fixative or by transcardiac perfusion with paraformaldehyde and glutaraldehyde and were then postfixed. Cryostat tissue sections of the lids were stained by immunohistochemistry using rabbit antisera to neuron-specific enolase (NSE), tyrosine hydroxylase (TH), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP), and substance P (SP), followed by a fluorescence visualization system. RESULTS Used as a marker for the overall nerve distribution, NSE antibodies revealed abundant smooth and varicose nerve fibers closely apposed to the basement membranes of acini of the meibomian glands. Numerous nerve fibers near the meibomian gland acini were immunoreactive for NPY and VIP, but nerve fibers containing TH, CGRP, and SP were more sparse in the meibomian glands. Nerve fibers also were visualized in other eyelid structures, including conjunctiva, epidermis, hair follicles, and subconjunctival lymphoid follicles. CONCLUSIONS The meibomian glands of rhesus and cynomolgous monkeys are richly innervated by diverse nerve fiber types. The immunohistochemical staining suggests a largely parasympathetic origin for this innervation, with relatively smaller contributions from sympathetic and sensory sources. These findings also suggest that meibomian gland secretion is under the control of diverse neurotransmitter-neuromodulator mechanisms.
Fast Kronecker Inference in Gaussian Processes with non-Gaussian Likelihoods

Gaussian processes (GPs) are a flexible class of methods with state of the art performance on spatial statistics applications. However, GPs require O(n3) computations and O(n2) storage, and popular GP kernels are typically limited to smoothing and interpolation. To address these difficulties, Kronecker methods have been used to exploit structure in the GP covariance matrix for scalability, while allowing for expressive kernel learning (Wilson et al., 2014). However, fast Kronecker methods have been confined to Gaussian likelihoods. We propose new scalable Kronecker methods for Gaussian processes with non-Gaussian likelihoods, using a Laplace approximation which involves linear conjugate gradients for inference, and a lower bound on the GP marginal likelihood for kernel learning. Our approach has near linear scaling, requiring O(DnD+1/D) operations and O(Dn2/D) storage, for n training data-points on a dense D > 1 dimensional grid. Moreover, we introduce a log Gaussian Cox process, with highly expressive kernels, for modelling spatiotemporal count processes, and apply it to a point pattern (n = 233,088) of a decade of crime events in Chicago. Using our model, we discover spatially varying multiscale seasonal trends and produce highly accurate long-range local area forecasts.
Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology

We previously demonstrated high-frequency, targeted DNA addition mediated by the homology-directed DNA repair pathway. This method uses a zinc-finger nuclease (ZFN) to create a site-specific double-strand break (DSB) that facilitates copying of genetic information into the chromosome from an exogenous donor molecule. Such donors typically contain two ∼750 bp regions of chromosomal sequence required for homology-directed DNA repair. Here, we demonstrate that easily-generated linear donors with extremely short (50 bp) homology regions drive transgene integration into 5–10% of chromosomes. Moreover, we measure the overhangs produced by ZFN cleavage and find that oligonucleotide donors with single-stranded 5′ overhangs complementary to those made by ZFNs are efficiently ligated in vivo to the DSB. Greater than 10% of all chromosomes directly incorporate this exogenous DNA via a process that is dependent upon and guided by complementary 5′ overhangs on the donor DNA. Finally, we extend this non-homologous end-joining (NHEJ)-based technique by directly inserting donor DNA comprising recombinase sites into large deletions created by the simultaneous action of two separate ZFN pairs. Up to 50% of deletions contained a donor insertion. Targeted DNA addition via NHEJ complements our homology-directed targeted integration approaches, adding versatility to the manipulation of mammalian genomes.
Attenuated Response of Aged Mice to Respiratory Francisella novicida Is Characterized by Reduced Cell Death and Absence of Subsequent Hypercytokinemia

Background Pneumonia and pulmonary infections are major causes of mortality among the growing elderly population. Age associated attenuations of various immune parameters, involved with both innate and adaptive responses are collectively known as immune senescence. These changes are likely to be involved with differences in host susceptibility to disease between young and aged individuals. Methodology/Principal Findings The objective of this study was to assess potential age related differences in the pulmonary host response in mice to the Gram-negative respiratory pathogen, Francisella novicida. We intranasally infected mice with F. novicida and compared various immune and pathological parameters of the pulmonary host response in both young and aged mice. Conclusions/Significance We observed that 20% of aged mice were able to survive an intranasal challenge with F. novicida while all of their younger cohorts died consistently within 4 to 6 days post infection. Further experiments revealed that all of the aged mice tested were initially able to control bacterial replication in the lungs as well as at distal sites of replication compared with young mice. In addition, the small cohort of aged survivors did not progress to a severe sepsis syndrome with hypercytokinemia, as did all of the young adult mice. Finally, a lack of widespread cell death in potential aged survivors coupled with a difference in cell types recruited to sites of infection within the lung confirmed an altered host response to Francisella in aged mice.
Numerical Simulation of Rising Damp Phenomenon

The treatment of rising damp in historical buildings walls is very complex. Moisture transfer in walls of old buildings, which are in direct contact with the ground, leads to a migration of soluble salts responsible for many building pathologies. The present work describes an extensive numerical analyse of rising damp phenomenon, using the software WUFI-2D, developed by Fraunhofer Institute for Building Physics. The results show that the numerical simulation describes very well the rising damp front for different boundary conditions and materials. The influence of the wall thickness, boundary conditions, composition of walls and material properties, such as, porosity and water absorption coefficient were analysed in detail.
Yielding, Strain Hardening, and Creep Under Nanoindentation of Precursor‐Derived Si–C–N Ceramics

The plastic deformation of the precursor-derived Si–C–N ceramics during indentation at room temperature displays permanent densification and creep, the former effect promoting strain hardening. This paper attempts to quantify the above two phenomena in these materials using, (i) reverse analysis of nanoindentation load–displacement curves in terms of yield stress (σy) and strain hardening exponent (n), and (ii) indentation creep analysis in terms of the strain rate sensitivity (m), respectively. The estimated values of n were commensurate with the capacity for densification, and were high among the amorphous Si–C–N materials. The present results indicate the importance of the optimum network connectivity in promoting densification in lieu of shear deformation in amorphous covalent networks. The densification-induced strain hardening led to a load dependence of m, and controlled the indentation size effect (ISE). The evolution of m showed good agreement with the cluster model, which relates the increase in the number density of isolated regions or discontinuities in the microstructure to a corresponding increase in m. Phase separation in these materials promoted the shear mode of plastic deformation and led to a decrease in n, an increase in m, and increased vulnerability to ISE.
Tools for Brain-Computer Interaction: A General Concept for a Hybrid BCI

The aim of this work is to present the development of a hybrid Brain-Computer Interface (hBCI) which combines existing input devices with a BCI. Thereby, the BCI should be available if the user wishes to extend the types of inputs available to an assistive technology system, but the user can also choose not to use the BCI at all; the BCI is active in the background. The hBCI might decide on the one hand which input channel(s) offer the most reliable signal(s) and switch between input channels to improve information transfer rate, usability, or other factors, or on the other hand fuse various input channels. One major goal therefore is to bring the BCI technology to a level where it can be used in a maximum number of scenarios in a simple way. To achieve this, it is of great importance that the hBCI is able to operate reliably for long periods, recognizing and adapting to changes as it does so. This goal is only possible if many different subsystems in the hBCI can work together. Since one research institute alone cannot provide such different functionality, collaboration between institutes is necessary. To allow for such a collaboration, a new concept and common software framework is introduced. It consists of four interfaces connecting the classical BCI modules: signal acquisition, preprocessing, feature extraction, classification, and the application. But it provides also the concept of fusion and shared control. In a proof of concept, the functionality of the proposed system was demonstrated.