Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring the Interplay of Trait Self–Control and Ego Depletion: Empirical Evidence for Ironic Effects

Trait self–control (TSC) has been conceptualized as a general and abstract ability to exert self–regulation across multiple domains that has mostly beneficial effects. However, its relationship to situational depletion of self–regulatory resources has received little attention. We systematically explore the interplay of trait and situational self–control in two studies (total N = 264). In contrast with a positive view of TSC, the results show greater ego depletion effects for high (vs. low) self–control abilities across such diverse domains as candy consumption (Study 1), risk–taking behaviour (Study 2) and achievement motivation (Study 2). It is proposed that these ironic effects are attributable to high–TSC individuals’ less frequent active inhibition of impulses in everyday life and their resulting lack of experience in resisting acute temptations. A third study (N> = 358) corroborated this general reasoning by showing that TSC is indeed associated with less frequent impulse inhibition in daily routines. Our data point to a downside of dispositional self–control in ego depletion paradigms. Other explanations and potential future avenues for resolving inconsistent findings across the literature are discussed. Copyright © 2013 European Association of Personality Psychology
Multivariate Time Series Classification with WEASEL+MUSE

Multivariate time series (MTS) arise when multiple interconnected sensors record data over time. Dealing with this high-dimensional data is challenging for every classifier for at least two aspects: First, a MTS is not only characterized by individual feature values, but also by the co-occurrence of features in different dimensions. Second, this typically adds large amounts of irrelevant data and noise. We present our novel MTS classifier WEASEL+MUSE (Word ExtrAction for time SEries cLassification + MUltivariate Symbols and dErivatives) which addresses both challenges. WEASEL+MUSE builds a multivariate feature vector, first using a sliding-window approach applied to each dimension of the MTS, then extracts discrete features per window and dimension. The feature vector is subsequently fed through feature selection, removing non-discriminative features, and analysed by a machine learning classifier. The novelty of WEASEL+MUSE lies in its specific way of extracting and filtering multivariate features from MTS by encoding context information into each feature, resulting in a small, yet very discriminative feature set useful for MTS classification. Based on a popular benchmark of $20$ MTS datasets, we found that WEASEL+MUSE is the most accurate domain agnostic classifier, when compared to the state of the art. The outstanding robustness of WEASEL+MUSE is further confirmed based on motion gesture recognition data, where it out-of-the-box achieved similar accuracies as domain-specific methods.
The effects of vagotomy and splanchnotomy on gastric motility in the sheep

Each of the four divisions of the ruminant stomach has its characteristic types of movement, as described by Wester (1926), Czepa & Stigler (1926, 1929), Mangold & Klein (1927), Schalk & Amadon (1928), and Phillipson (1939). Closely related to reticulo-ruminal motility is the phenomenon of rumination, shown by Stigler (1931, 1933, 1949) to be carried out by coordinated activity of the stomach and oesophagus with the respiratory apparatus. The existence of a nervous co-ordinating mechanism for gastric movements in the ruminant has been suggested by experiments of Ellenberger (1883), Wester (1926), Mangold & Klein (1927), Lagerlof & Hoflund (1936) and Hoflund (1940). The evidence, however, was incomplete; Mangold & Klein relied upon observations on laparotomized, anaesthetized animals, and on post-mortem findings after chronic neurectomies, while Hofilund based his observations on the auscultation of ruminal sounds and on post-mortem examination following section of various combinations of branches of the abdominal vagi. A detailed study has been made of the effects on reticulo-ruminal and abomasal motility of total and partial vagotomy and of splanchnotomy, and the results are described in this paper.
Effects of thalamic midline nuclei stimulation upon lateral geniculate transmission in rats: inhibition of principal cells and excitation of internuncial cells.

Effects of low-frequency stimulation of thalamic midline nuclei (MID) upon unitary activities of principal (P) and internuncial (I) cells of the lateral geniculate body were examined in urethane-anesthetized rats. P-cells responsed to single shocks to the optic tract (OT) with single spikes at short latencies (initial spike, IS), followed by a phase of inhibition which lasted for more than 150 msec and ended with a burst of grouped discharges (late discharge, LD). Excitability of P-cells, assessed with the response probability of IS to testing OT shocks, was reduced for about 300 msec after single shock stimulation of MID. Usually this excitability depression became evident about 20 msec after MID shocks and was maximum from 50 to 100 msec. LDs were made more vigorous when MID shocks were given almost simultaneously with testing OT shocks. This was interpreted that MID stimulation induced an inhibition in P-cells and it summed with that induced by OT stimulation. That the MID-induced inhibition of P-cells was due to IPSPs was proved by the quasi-intracellular recording. I-cells, the units fired repetitively by single OT shocks and have been presumed to be inhibitory neurons acting upon P-cells, were found to receive from MID stimulation an excitatory effect followed by an inhibitory one of long duration. It was suggested that the primary inhibition of P-cells by low-frequency stimulation of MID would be a direct consequence of the primary excitation of I-cells.
Job Embeddedness: A New Attitudinal Measure

Job embeddedness is a relatively new concept that offers the potential to improve our ability to explain why people stay in their jobs. This article outlines the development and testing of new measures of on‐ and off‐the‐job embeddedness. Analyses of survey data show the measures demonstrate adequate psychometric properties across samples (three military and one nonmilitary organization) and across different organizational levels, genders, and tenure, as well as discriminant validity over other turnover‐relevant constructs and appropriate convergent validity with a number of further constructs identified in the literature.
The price of greatness : resolving the creativity and madness controversy

1. A Touch of Madness? 2. Determining Greatness 3. The Early Years 4. The Adult Years 5. Impediments to Eminence 6. The Measurement of Achievement 7. Mental Illness within the Professions 8. Mental Symptoms and Creative Activity 9. Predicting "True" Greatness
Knowledge, attitudes, sexual practices and STI/HIV prevalence in male sex workers and other men who have sex in Tel Aviv, Israel: a cross-sectional study

Objective To explore knowledge, attitudes and sexual practices of male sex workers (MSW) in Tel Aviv in comparison with men who have sex with men (MSM) classified by their risk behaviours and to outline attributes related to sexually transmitted infections (STI)/HIV prevalence. Methods MSW were recruited for this cross-sectional study from designated street venues and gay-dating internet site. MSM were recruited from gay-related venues and divided into high-risk MSM (HRMSM) if they performed unprotected anal intercourse in the last 6 months with an HIV-discordant/unknown partner and to low-risk MSM (LRMSM). Each participant completed a questionnaire and was tested for STI/HIV. Results Of 87 MSW and 635 MSM approached, 53 (60.9%) and 235 (37.0%) participated, respectively. Street-MSW (N=32) had more female sex partners and were more drug dependent than internet-MSW (N=21). No differences were found in their knowledge regarding STI/HIV transmission, practices and STI/HIV burden. Compared with HRMSM, MSW had different demographic attributes and demonstrated more realistic perception regarding the risk to getting STI/HIV, while no differences were found in their knowledge and sexual practices. STI burden among MSW, HRMSM (N=119) and LRMSM (N=116) were 28.3%, 23.5% and 10.3% (p=0.009) and HIV burden among MSW, HRMSM and LRMSM were 5.6%, 9.2% and 0%, (p=0.001), respectively. Multivariate models evaluating attributes associated with HIV/STI diagnosis did not find sex work to be significant if the variable used was MSW versus HRMSM, regardless of the adjustments performed. However, when MSW versus LRMSM was used in the model, sex work was associated with STI/HIV diagnosis. Conclusions Street-MSW and internet-MSW, similar to all MSW and HRMSM, had comparable sexual practices and had no difference in their STI/HIV prevalence.
Cold adaptation of fungi obtained from soil and lake sediment in the Skarvsnes ice-free area, Antarctica.

A total of 71 isolates were collected from lake sediment and soil surrounding lakes in the Skarvsnes area, Antarctica. Based on ITS region sequence similarity, these isolates were classified to 10 genera. Twenty-three isolates were categorized as ascomycetous fungi from five genera (Embellisia, Phoma, Geomyces, Tetracladium or Thelebolus) and 48 isolates were categorized as basidiomycetous fungi in five genera (Mrakia, Cryptococcus, Dioszegia, Rhodotorula or Leucosporidium). Thirty-five percent of culturable fungi were of the genus Mrakia. Eighteen isolates from eight genera were selected and tested for both antifreeze activity and capacity for growth under temperatures ranging from -1 to 25 °C. Rhodotorula sp. NHT-2 possessed a high degree of sequence homology with R. gracialis, while Leucosporidium sp. BSS-1 possessed a high degree of sequence homology with Leu. antarcticum (Glaciozyma antarctica), and these two isolates demonstrated antifreeze activity. All isolates examined were capable of growth at -1 °C. Mrakia spp. , while capable of growth at -1 °C, did not demonstrate any antifreeze activity and exhibited only limited secretion of extracellular polysaccharides. Species of the genus Mrakia possessed high amounts of unsaturated fatty acids, suggesting that members of this genus have adapted to cold environments by increasing their membrane fluidity.
Modeling Aluminum Smelter Plants Using Sliced Inverse Regression With a View Towards Load Flexibility

This paper describes the application of sliced inverse regression to model the electrochemical process of aluminum smelter plants. Real data measurements obtained during several years in a Spanish industrial environment are used to illustrate the main dependencies between parameters. Nonlinear relations between the output variables and relevant linear combinations of input variables are deduced. An exploratory statistical analysis is also presented, checking for correlations and possible linear dependencies. The developed model is used to analyze the range of electrical power demand variations as a consequence of modifications in chemical and electrical parameters. An example is described maintaining constant the aluminum production. The results can be considered for future load flexibility programs, which might include aluminum smelter plants as a flexible industrial customer.
Treatment of Hodgkin's Disease: A Twenty-Year Follow-up of Patients at a Center in Korea

Hodgkin's disease (HD) is a hematologic malignancy which shows common features regardless of race, but racial differences may be considered with certain clinical characteritcs. HD in Korea shows somewhat different characteristics when compared to cases in Western countries. We evaluated the clinical and histopathologic characteristics of HD, the outcomes of various chemotherapy regimens, and prognostic factors of HD in Korea. One hundred and five patients with initial histopathologic diagnosis of Hodgkin's disease were retrospectively reviewed 20 years after diagnosis at Yonsei University College of Medicine. Nodular sclerosis was the most common histopathogic subtype (41%) and mixed cellularity was nearly as common (40%). The overall complete remission rate (CR) was 87.6%. The disease-free survival (DFS) and overall survival (OS) rate were 79.2% and 84.8% at 5-years, 70% and 79.2% at 10- and 20-years. There were no significant differences in CR rate and DFS, but OS rates were significantly higher in m-BACOP and ABVD regimen. Univariate analysis revealed that age, B-symptom, ECOG scale, Ann Arbor stage, international prognostic index, and serum β2-microglobulin level were significant prognostic factors for both DFS and OS. Multivariate analysis demonstrated that age, B symptoms, and ECOG scale were significant prognostic factors for OS only. In conclusion, the survival rates of HD patients in our center were superior to those of previous reports in Korea and Western countries. Considering the higher OS rate and decreased incidence of side effects, the ABVD regimen may be recommended for the initial treatment of Hodgkin's disease.
Age -related effects on the threshold equalizing noise (TEN) test

Title of Document: AGE-RELATED EFFECTS ON THE THRESHOLD EQUALIZING NOISE (TEN) TEST Christine Gmitter Doctor of Audiology, 2008 Directed By: Professor Sandra Gordon-Salant Department of Hearing and Speech Sciences Some individuals with sensorineural hearing loss have certain places along the basilar membrane where inner hair cells and/or neurons are damaged or destroyed and consequently have ceased to function. These regions have been referred to as “dead regions” in the literature. The TEN (HL) test is a relatively quick behavioral test designed to identify cochlear dead regions. The test relies on the detection of pure-tone signals in the presence of a specially designed broadband noise (threshold equalizing noise) masker. The TEN (HL) test was validated on young to middle aged adult listeners, an age group which does not represent that of all adults with hearing loss. The goal of this study was to evaluate the effects of age on the TEN (HL) test. The TEN (HL) test was administered to 18 younger and 18 older adults with normal to near-normal hearing sensitivity at seven different frequencies in three different levels of TEN noise. These measures were conducted twice to assess test re-test reliability. The older group demonstrated significantly poorer (higher) SNRs compared to the younger group at all three TEN noise levels and for all seven test frequencies. The greatest difference between groups was observed for the highest level of TEN noise. The greatest difference in SNRs was at 4000 Hz compared to other test frequencies for both groups. Both groups performed best (lowest SNRs) at 4000 Hz compared to the other test frequencies. Finally, a main effect of trial was found, revealing that both groups performed statistically better (lower SNRs) on the second trial; however the small magnitude of this improvement (0.37 dB), suggests that the TEN (HL) test has good repeatability for clinical use, at least within the time period assessed. Although there were significant differences between the two groups, overall the TEN (HL) test yielded accurate results in classifying all normal to near-normal hearing participants as not having a dead region. The significantly higher (poorer) SNRs associated with age, combined with the expected difference in SNRs associated with hearing loss, may allow for older hearing-impaired individuals to demonstrate abnormally high SNRs on the TEN (HL) test in the absence of a cochlear dead region. Future studies that include younger and older participants with normal hearing and hearing loss are needed to assess these differences and examine whether different norms are needed for this older population. AGE-RELATED EFFECTS ON THE THRESHOLD EQUALIZING NOISE (TEN) TEST
Life and death by P53

p53 is a multifunctional protein which plays a role in modulating gene transcription, policing cell cycle checkpoints, activating apoptosis, controlling DNA replication and repair, maintaining genomic stability and responding to genetic insults. Mutation of the p53 gene confers the single greatest known selective advantage favoring cancer formation. Point mutations result not only in the loss of tumor suppressor functions, but also in the gain of tumor promotion functions. These dual circumstances may be unique to p53 and, in part, could explain the relatively powerful force behind this selection pressure. General mechanisms of gain of function by mutated p53 may include alteration in transcriptional modulation and newly acquired targets for transcriptional regulation and protein binding. Despite the direct significance of p53 mutations, loss of the remaining wild‐type allele is usually required for the formation of tumors in the natural setting. Novel applications of the basic scientific knowledge of p53 could lead to an improvement in cancer treatment, hopefully in the not so distant future.
Valuing R&D Projects in a Portfolio: Evidence from the Pharmaceutical Industry

Understanding the value of a product development project is central to a firm's choice of project portfolio. The value of a project to a firm depends not only on its properties but also on the other projects being developed by the firm. This is due to interactions with the other projects that address the same consumer need and require the same development resources. In this study, we empirically investigate the structure and significance of these portfolio-level project interactions. Using a self-developed pharmaceutical industry data set, we conduct an event study around the failure of phase III clinical trials and their effect on the market valuation of the firm. The study exploits the natural experiment of a product development failure to give us a measure of the value of a drug development project to a firm. We then explain the variance in the value of projects based on interactions with other projects in the firm's portfolio. We find that the presence of other projects targeting the same market and a build-up of projects that require the same development resources reduce the value of a development project. In addition to providing evidence on the significance and structure of these portfolio-level project interactions, the empirical model estimated in this paper also provides a data-driven approach to valuing projects that may be relevant to licensing transactions.
Automatic multiresolution age-related macular degeneration detection from fundus images

Age-related Macular Degeneration (AMD) is a leading cause of legal blindness. As the disease progress, visual loss occurs rapidly, therefore early diagnosis is required for timely treatment. Automatic, fast and robust screening of this widespread disease should allow an early detection. Most of the automatic diagnosis methods in the literature are based on a complex segmentation of the drusen, targeting a specific symptom of the disease. In this paper, we present a preliminary study for AMD detection from color fundus photographs using a multiresolution texture analysis. We analyze the texture at several scales by using a wavelet decomposition in order to identify all the relevant texture patterns. Textural information is captured using both the sign and magnitude components of the completed model of Local Binary Patterns. An image is finally described with the textural pattern distributions of the wavelet coefficient images obtained at each level of decomposition. We use a Linear Discriminant Analysis for feature dimension reduction, to avoid the curse of dimensionality problem, and image classification. Experiments were conducted on a dataset containing 45 images (23 healthy and 22 diseased) of variable quality and captured by different cameras. Our method achieved a recognition rate of 93:3%, with a specificity of 95:5% and a sensitivity of 91:3%. This approach shows promising results at low costs that in agreement with medical experts as well as robustness to both image quality and fundus camera model.
On Theories Explaining the Success of the Gravity Equation

We examine whether two important theories of trade, the Heckscher‐Ohlin theory and the increasing returns theory, can account for the empirical success of the so‐called gravity equation. Since versions of both theories can predict this equation, we tackle the model identification problem by conditioning bilateral trade relations on factor endowment differences and on the share of intraindustry trade. Only for large differences in factor endowments does the Heckscher‐Ohlin model predict perfect production specialization in different countries as well as the gravity equation, and trade is purely in goods produced with different factor intensities. Our empirical analysis yields three findings. First, the predictions of the perfect specialization versions of both theories are rejected by the data and so are unlikely explanations for the empirical success of the gravity equation. Second, a model of imperfect specialization that includes both increasing returns and factor endowments as sources of trade has a mixed performance: it correctly predicts production of more differentiated goods when the level of intraindustry trade is greater; however, the predicted link to factor proportions is tenuous. Third, the predictions of a model with imperfect specialization that relies solely on differences in factor endowments find support in the data. These results suggest that factor endowments and increasing returns explain different components of the international variation of production patterns and trade volumes.
Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma.

PURPOSE CC chemokine receptor 7 (CCR7) plays a critical role in the migration of activated dendritic cells to regional lymph nodes. Recent studies have shown that CCR7 is involved in metastasis in some malignant diseases. The role of CCR7 in esophageal squamous cell carcinoma (SCC) has not yet been clarified. EXPERIMENTAL DESIGN We performed reverse transcription-PCR analysis for CCR7 in 20 esophageal SCC cell lines and immunohistochemical analysis of 96 esophageal SCC samples. We then performed a cell migration assay, F-actin polymerization, and a phagokinetic assay on esophageal SCC cell lines in the presence of CCL21, a ligand of CCR7. RESULTS CCR7 mRNA was detected in 9 of 20 esophageal SCC cell lines. Immunoreactive CCR7 was found mainly in esophageal cancer cells. High CCR7 expression was significantly correlated with esophageal SCC lymphatic permeation, lymph node metastasis, tumor depth, and tumor-node-metastasis stage and was associated with poor survival. In vitro studies demonstrated that CCL21 significantly increased the cell migration ability of esophageal SCC cell lines, and pseudopodia formation was induced by CCL21 stimulation. Furthermore, CCL21 markedly enhanced the motility of esophageal carcinoma cell lines by the phagokinetic assay. CONCLUSIONS The results suggested that the CCR7/CCL21 receptor ligand system may play a role in the lymph node metastasis of esophageal SCC.