Miracle-dz/UniFAR-FTUs huggingface dataset:
A unifying view of the spectral energy distributions of blazars

ABSTRA C T We collect data at well-sampled frequencies from the radio to the g-ray range for the following three complete samples of blazars: the Slew survey, the 1-Jy samples of BL Lacs and the 2-Jy sample of flat-spectrum radio-loud quasars (FSRQs). The fraction of objects detected in g-rays (E * 100 MeV) is ,17, 26 and 40 per cent in the three samples respectively. Except for the Slew survey sample, g-ray detected sources do not differ either from other sources in each sample, or from all the g-ray detected sources, in terms of the distributions of redshift, radio and X-ray luminosities or of the broad-band spectral indices (radio to optical and radio to X-ray). We compute average spectral energy distributions (SEDs) from radio to g-rays for each complete sample and for groups of blazars binned according to radio luminosity, irrespective of the original classification as BL Lac or FSRQ. The resulting SEDs show a remarkable continuity in that (i) the first peak occurs in different frequency ranges for different samples/luminosity classes, with most luminous sources peaking at lower frequencies; (ii) the peak frequency of the g-ray component correlates with the peak frequency of the lower energy one; (iii) the luminosity ratio between the high and low frequency components increases with bolometric luminosity. The continuity of properties among different classes of sources and the systematic trends of the SEDs as a function of luminosity favour a unified view of the blazar phenomenon: a single parameter, related to luminosity, seems to govern the physical properties and radiation mechanisms in the relativistic jets present in BL Lac objects as well as in FSRQs. The general implications of this unified scheme are discussed while a detailed theoretical analysis, based on fitting continuum models to the individual spectra of most g-ray blazars, is presented in a separate paper.
Quasi-Periodic Features Due to Clumps Orbiting around a Black Hole

The expected Fourier power-spectrum density is examined with regard to the shape and quality factor Q of features which are predicted to appear in a signal from clumps orbiting near a marginally stable orbit of a compact body. It is shown that clumps distributed randomly in a narrow range of radii produce quasi-periodic oscillations with Q w 102, similar to those observed in many low-mass X-ray binaries.
Disease progression model for Clinical Dementia Rating–Sum of Boxes in mild cognitive impairment and Alzheimer’s subjects from the Alzheimer’s Disease Neuroimaging Initiative

Background The objective of this analysis was to develop a nonlinear disease progression model, using an expanded set of covariates that captures the longitudinal Clinical Dementia Rating Scale–Sum of Boxes (CDR–SB) scores. These were derived from the Alzheimer’s Disease Neuroimaging Initiative ADNI-1 study, of 301 Alzheimer’s disease and mild cognitive impairment patients who were followed for 2–3 years. Methods The model describes progression rate and baseline disease score as a function of covariates. The covariates that were tested fell into five groups: a) hippocampal volume; b) serum and cerebrospinal fluid (CSF) biomarkers; c) demographics and apolipoprotein Epsilon 4 (ApoE4) allele status; d) baseline cognitive tests; and e) disease state and comedications. Results Covariates associated with baseline disease severity were disease state, hippocampal volume, and comedication use. Disease progression rate was influenced by baseline CSF biomarkers, Trail-Making Test part A score, delayed logical memory test score, and current level of impairment as measured by CDR–SB. The rate of disease progression was dependent on disease severity, with intermediate scores around the inflection point score of 10 exhibiting high disease progression rate. The CDR–SB disease progression rate in a typical patient, with late mild cognitive impairment and mild Alzheimer’s disease, was estimated to be approximately 0.5 and 1.4 points/year, respectively. Conclusions In conclusion, this model describes disease progression in terms of CDR–SB changes in patients and its dependency on novel covariates. The CSF biomarkers included in the model discriminate mild cognitive impairment subjects as progressors and nonprogressors. Therefore, the model may be utilized for optimizing study designs, through patient population enrichment and clinical trial simulations.
“Degrowth” vs. Other Types of Growth: Labeling Affects Emotions but Not Attitudes

ABSTRACT Questioning the compatibility of economic growth and environmental sustainability, some scholars and activists call for a degrowth strategy. This idea presents an attack on the economic growth paradigm, and it has thus raised considerable attention. Yet, although many agree with questioning economic growth, a debate continues as to whether the term “degrowth” is (dis)advantageous in wider public communications. This debate, however, lacks empirical evidence. Here, we present two studies on how “degrowth” is perceived compared to other relevant terms. In Study 1, we show that “degrowth” elicits more negative affective and emotional reactions compared to “post-growth” and “prosperity without growth. ” In Study 2, we find that the effects of labeling on attitudes and voting intentions toward a sustainable economy are relatively small. These initial results suggest that “degrowth” may evoke somewhat more negative emotional reactions than similar terms, but this may not have significant consequences. We discuss the results and draw implications for communication and further research.
A systems-level “misunderstanding”: the plasma metabolome in Huntington’s disease

Huntington's disease (HD) is a rare neurodegenerative disease caused by the expansion of an N‐terminal repeat in the huntingtin protein. The protein is expressed in all cells in the body; hence, peripheral tissues, such as blood, may recapitulate processes in the brain. The plasma metabolome may provide a window into active processes that influence brain health and a unique opportunity to noninvasively identify processes that may contribute to neurodegeneration. Alterations in metabolic pathways in brain have been shown to profoundly impact HD. Therefore, identification and quantification of critical metabolomic perturbations could provide novel biomarkers for disease onset and disease progression.
Effect of Sodium Ascorbate and Delayed Bonding on the Bond Strength of Silorane and Two-step Self-etch Adhesive Systems in Bleached Enamel

Background and aims. Studies have shown decreased bond strength of composite resin to human and bovine bleached enamel. This study evaluated the effect of sodium ascorbate and delayed bonding on the bond strength of two adhesive systems to bleached enamel. Materials and methods. The labial surfaces of 150 sound bovine incisor teeth were abraded with abrasive paper. The teeth were randomly divided into 8 groups: A: control; B: bleached with 35% hydrogen peroxide; C: bleached with 35% hydrogen peroxide + sodium ascorbate gel; and D: bleached with 35% hydrogen peroxide + delayed bonding. In groups A‒D, silorane adhesive system and Filtek silorane composite resin were used. In groups E‒H, the same preparation methods of groups A-D were used. Two-step self-etch Clearfil SE Bond adhesive systems and AP-X composite resin were administered. Shear bond strength of each group was measured. Two samples were prepared for each surface preparation for ultra-structural evaluation. Two-way ANOVA and Tukey test were used for data analysis at P<0.05. Results. The interaction between the adhesive system type and surface preparation protocol was significant (P=0.014), withsignificant differences in shear bond strengths in terms of the adhesive systems (P<0.01). There were significant differences in shear bond strength in terms of surface preparation techniques irrespective of the adhesive system (P<0.01). Conclusion. The results showed that bleaching with 35% hydrogen peroxide decreased the shear bond strength values with both adhesive systems, and a one-week delay in bonding and 10% sodium ascorbate for10 minutes restored the bond strength in both adhesive systems.
Chapter 3 : Neuronal activity in area V 1 during contour grouping conforms to a growth-cone model of object-based attention

Attention can select elements of spatially extended objects and group them into coherent representations, but the processes responsible for object-based attention have remained unclear. Shape-selective neurons in higher areas of the visual cortex could contribute to object-based attention by providing feedback to lower areas to enhance the representation of image elements that belong to a relevant shape (Van der Velde and de Kamps, 2001). Another possibility is that attention gradually spreads according to the Gestalt rules, successively adding new elements to a growing object representation. Here we investigated the dynamics of object-based attention by recording the activity of area V1 neurons in a contour grouping task. Our results show that attention gradually spreads across the object representation as neuronal responses evoked by contour elements further along a relevant curve are enhanced at progressively later times, while responses evoked by the initial segments of the curve stay at an enhanced level. The speed of the attentional spreading process decreased at locations where the relevant curve came close to an irrelevant one. Our findings inspire a " growth-cone " model where attention spreads at multiple spatial scales by enhancing the responses of neurons with differently sized receptive fields, at a pace of approximately 50ms per receptive field.
Evaluating the preschool life skills program to teach school readiness skills: An irish pilot study

ABSTRACT The Preschool Life Skills (PLS; Hanley et al., 2007) program is a preventive program targeting 13 important school readiness skills for preschool children. The PLS program addresses communication and social skill development and aims to prevent the development of problem behavior. These skills have been identified as core skills for success in later educational settings by kindergarten teachers and are the most commonly taught functionally equivalent and alternative skills in intervention for problem behavior. The current study evaluated the PLS program within an Irish educational context. Results indicated increases in target preschool life skills and decreases in problem behavior following intervention. Evidence of generalization and maintenance also were observed.
Attachment anxiety predicts depression and anxiety symptoms following coronary artery bypass graft surgery

Objective Depression and anxiety are associated with poor recovery in coronary artery bypass graft (CABG) patients, but little is known about predictors of depression and anxiety symptoms. Design We tested the prospective association between attachment orientation, and symptoms of depression and anxiety in CABG patients, 6–8 weeks, and 12 months following surgery. Method One hundred and fifty‐five patients who were undergoing planned CABG surgery were recruited. Patients completed questionnaires measuring attachment, depression, and anxiety prior to surgery, then 6–8 weeks, and 12 months after surgery. Results Attachment anxiety predicted symptoms of depression and anxiety at both follow‐up time points, whereas attachment avoidance was not associated with depression or anxiety symptoms. The findings remained significant when controlling for baseline mood scores, social support, demographic, and clinical risk factors. Conclusion These results suggest that attachment anxiety is associated with short‐term and long‐term depression and anxiety symptoms following CABG surgery. These results may offer important insight into understanding the recovery process in CABG surgery. Statement of contribution What is already known on this subject? Depression and anxiety symptoms are twice more likely to occur in coronary artery bypass graft (CABG) populations than in any other medical group. Depression and anxiety are associated with poor recovery following cardiac surgery. Predictors of depression and anxiety in CABG patients have been underexplored. What does this study add? This study highlights the importance of close interpersonal relationships on health. Attachment anxiety was prospectively associated with higher levels of depression and anxiety. These results add to understanding mechanisms linked to recovery following CABG.
Differential Effects of Toluene and Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area

Drugs of abuse increase the activity of dopaminergic neurons of the ventral tegmental area (VTA), and output from the VTA is critical for both natural and drug-induced reward and reinforcement. Ethanol and the abused inhalant toluene both enhance VTA neuronal firing, but the mechanisms of this effect is not fully known. In this study, we used extracellular recordings to compare the actions of toluene and ethanol on DA VTA neurons. Both ethanol and toluene increased the firing rate of DA neurons, although toluene was ~100 times more potent than ethanol. The mixed ion channel blocker quinine (100 μM) blocked the increases in firing produced by ethanol and toluene, indicating some similarity in mechanisms of excitation. A mixture of antagonists of GABA and cholinergic receptors did not prevent toluene-induced or ethanol-induced excitation, and toluene-induced excitation was not altered by co-administration of ethanol, suggesting independent mechanisms of excitation for ethanol and toluene. Concurrent blockade of NMDA, AMPA, and metabotropic glutamate receptors enhanced the excitatory effect of toluene while having no significant effect on ethanol excitation. Nicotine increased firing of DA VTA neurons, and this was blocked by the nicotinic antagonist mecamylamine (1 μM). Mecamylamine did not alter ethanol or toluene excitation of firing but the muscarinic antagonist atropine (5 μM) or a combination of GABA antagonists (bicuculline and CGP35348, 10 μM each) reduced toluene-induced excitation without affecting ethanol excitation. The Ih current blocker ZD7288 abolished the excitatory effect of toluene but unlike the block of ethanol excitation, the effect of ZD7288 was not reversed by the GIRK channel blocker barium, but was reversed by GABA antagonists. These results demonstrate that the excitatory effects of ethanol and toluene have some similarity, such as block by quinine and ZD7288, but also indicate that there are important differences between these two drugs in their modulation by glutamatergic, cholinergic, and GABAergic receptors. These findings provide important information regarding the actions of abused inhalants on central reward pathways, and suggest that regulation of the activation of central dopamine pathways by ethanol and toluene partially overlap.
Validating and prioritizing quality rules for managing technical debt: An industrial case study

One major problem in using static analyzers to manage, monitor, control, and reason about technical debt is that industrial projects have a huge amount of technical debt which reflects hundreds of quality rule violations (e.g., high complex module or low comment density). Moreover the negative impact of violating quality rules (i.e., technical debt interest) may vary across rules or even across contexts. Thus, without a context-specific validation and prioritization of quality rules, developers cannot effectively manage technical debt. This paper reports on a case study aimed at exploring the interest associated with violating quality rules; i.e., we investigate if and which quality rules are important for software developers. Our empirical method consists of a survey and a quantitative analysis of the historical data of a CMMI Level 5 software company. The main result of the quantitative analysis is that classes violating several quality rules are five times more defect prone than classes not violating any rule. The main result of the survey is that some rules are perceived by developers as more important than others; however, there is no false positive (i.e., incorrect rule or null interest). These results pave the way to a better practical use of quality rules to manage technical debt and describe new research directions for building a scientific foundation to the technical debt metaphor.
Getting at the truth or getting along: Accuracy- versus impression-motivated heuristic and systematic processing.

Two studies examined the heuristic and systematic processing of accuracy- versus impression-motivated individuals expecting a discussion with a partner believed to hold either a favorable or unfavorable opinion on the discussion issue. Given the goal of having a pleasant interaction, impressionmotivated (versus accuracy-motivated) participants in both studies were particularly likely to express attitudes that were evaluatively consistent with the partner's opinion, reflecting their selective use of a "go along to get along" heuristic. Study 2 yielded stronger evidence for the distinct nature of heuristic and systematic processing in the service of accuracy versus impression goals. In this study, the evaluative implication of impression-motivated participants' low-effort application of a "go along to get along" heuristic biased their more effortful, systematic processing, leading to attitudes consistent with the partner's views. In contrast, given the goal of determining an accurate issue opinion, accuracy-motivated participants exhibited relatively evenhanded systematic processing, resulting in attitudes unbiased by the partner's opinion. The results underscore the utility of a dual-process approach to understanding motivated cognition. Intuition and experience suggest that various motives can influence the way in which people process information and the judgments that result. That is, the motivated perceiver's cognitive processes will be a direct reflection of the goals that they are intended to satisfy. Using the heuristic-systematic model (Chaiken, 1980, 1987; Chaiken, Liberman, & Eagly, 1989) as a theoretical framework, the present research aims to elucidate the distinct ways in which accuracy versus impression motives are served by both heuristic and systematic processes.
Small Business Research 1 RESOURCES , LONG-TERM ENTREPRENEURIAL ORIENTATION , AND FIRM PERFORMANCE

tudies showing the possibility that the effect of entrepreneurship is long-term in nature are called for. The primary contribution of this article is that the entrepreneurial orientation (EO) employed here has a long-time effect on perceived performance. Another contribution, when controlling for past EO, is that this variable has implications for all three performance measures (perceived performance compared to competitors, relatively sales growth and relatively employment growth). As entrepreneurial posture tends to be resource-consuming these result are of interest for managers seeing that EO over time can contribute to value-adding activities. For scholars this result is encouraging when trying to gain new insight and knowledge about the intended effect of entrepreneurial activities. Surprisingly, the results only partly supported the importance of the seven resources tested; the manager’s education and experience, the use of organizational networks, the firm’s location, board, patented products/services and technology, and financial position, for performance. Hence, other resources have to be explored and tested.
Computations underlying Drosophila photo-taxis, odor-taxis, and multi-sensory integration

To better understand how organisms make decisions on the basis of temporally varying multi-sensory input, we identified computations made by Drosophila larvae responding to visual and optogenetically induced fictive olfactory stimuli. We modeled the larva's navigational decision to initiate turns as the output of a Linear-Nonlinear-Poisson cascade. We used reverse-correlation to fit parameters to this model; the parameterized model predicted larvae's responses to novel stimulus patterns. For multi-modal inputs, we found that larvae linearly combine olfactory and visual signals upstream of the decision to turn. We verified this prediction by measuring larvae's responses to coordinated changes in odor and light. We studied other navigational decisions and found that larvae integrated odor and light according to the same rule in all cases. These results suggest that photo-taxis and odor-taxis are mediated by a shared computational pathway. DOI: http://dx.doi. org/10.7554/eLife.06229. 001
Phonology versus phonetics in loanword adaptations A reassessment of English vowels in French *

This electronic file may not be altered in any way. The author(s) of this article is/are permitted to use this PDF file to generate printed copies to be used by way of offprints, for their personal use only. Permission is granted by the publishers to post this file on a closed server which is accessible to members (students and staff) only of the author’s/s’ institute, it is not permitted to post this PDF on the open internet. For any other use of this material prior written permission should be obtained from the publishers or through the Copyright Clearance Center (for USA: www.copyright.com). Please contact rights@benjamins.nl or consult our website: www.benjamins. com
TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress

Transcription factor IIS (TFIIS) stimulates RNA cleavage by RNA polymerase II by allowing backtracked enzymes to resume transcription elongation. Yeast cells do not require TFIIS for viability, unless they suffer severe transcriptional stress due to NTP-depleting drugs like 6-azauracil or mycophenolic acid. In order to broaden our knowledge on the role of TFIIS under transcriptional stress, we carried out a genetic screening for suppressors of TFIIS-lacking cells’ sensitivity to 6-azauracil and mycophenolic acid. Five suppressors were identified, four of which were related to the transcriptional regulation of those genes encoding ribosomal components [rRNAs and ribosomal proteins (RP)], including global regulator SFP1. This led us to discover that RNA polymerase II is hypersensitive to the absence of TFIIS under NTP scarcity conditions when transcribing RP genes. The absence of Sfp1 led to a profound alteration of the transcriptional response to NTP-depletion, thus allowing the expression of RP genes to resist these stressful conditions in the absence of TFIIS. We discuss the effect of transcriptional stress on ribosome biogenesis and propose that TFIIS contributes to prevent a transcriptional imbalance between rDNA and RP genes.
Optimal resource allocation for OFDM uplink communication: A primal-dual approach

Orthogonal frequency division multiplexing (OFDM) with dynamic resource allocation is widely considered to be a key component of most emerging broadband wireless access networks. However, resource allocation in an OFDM system is complicated, especially in the uplink due to the heterogeneity of the users' subchannel conditions, individual resource constraints and application requirements. We formulate the resource allocation problem as a convex optimization problem, which has a unique optimal objective value but might have multiple corresponding optimal solutions. We then present a primal-dual based algorithm that is distributed, low complexity, and is provably global convergent to the optimal solutions. The convergence and optimality of the algorithm is studied through a realistic OFDM simulator.