Miracle-dz/UniFAR-FTUs huggingface dataset:
Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome

Postprandial dyslipidaemia may be a plausible mechanism by which polycystic ovary syndrome (PCOS) increases cardiovascular risk. We sought to investigate whether the postprandial glucose and insulin and lipid and lipoprotein responses, including that of apolipoprotein B-48 (apoB-48) containing chylomicrons, to a mixed meal are different in obese PCOS women when compared to obese control subjects and whether differences, if any, are related to obesity, insulin resistance (IR), hyperandrogenaemia, or PCOS status. 26 women with PCOS (age 30.4 ± 1.2 years (mean ± SEM), body mass index (BMI) 36.8 ± 1.5 kg/m2) and 26 non-PCOS subjects (age 34.1 ± 0.9 years, BMI 31.5 ± 1.0 kg/m2) were studied before and up to 8 hours following a standard mixed meal. AUC-triglyceride (AUC-TG) was higher and AUC-high-density lipoprotein (AUC-HDL) lower in PCOS women. These differences were not apparent when BMI was accounted for. Insulin sensitivity (S I), AUC-apoB-48, and AUC-apolipoprotein B (AUC-apoB) were found to be independent predictors of AUC-TG, accounting for 55% of the variance. Only AUC-insulin remained significantly elevated following adjustment for BMI. Obesity related IR explains postprandial hypertriglyceridaemia and hyperinsulinaemic responses. Management of obesity in premenopausal women with PCOS is likely to reduce their cardiovascular risk burden.
Developmental change in amygdala reactivity during adolescence: effects of family history of depression and stressful life events.

OBJECTIVE Although heightened amygdala reactivity is observed in patients with major depression, two critical gaps in our knowledge remain. First, it is unclear whether heightened amygdala reactivity is a premorbid vulnerability or a consequence of the disorder. Second, it is unknown how and when this neural phenotype develops. The authors sought to address these gaps by evaluating developmental change in threat-related amygdala reactivity in adolescents at high or low risk for depression based on family history, before onset of disorder. METHOD At baseline and again 2 years later, adolescents (initially 11-15 years of age) participated in a functional MRI paradigm that elicited threat-related amygdala reactivity. After quality control, data were available for 232 adolescents at wave 1 and 197 adolescents at wave 2; longitudinal data meeting quality control at both waves were available for 157 of these participants. Change in amygdala reactivity was assessed as a function of family history of depression and severity of stressful life events. RESULTS Threat-related amygdala reactivity increased with age in participants with a positive family history regardless of the severity of life stress reported, and it increased in adolescents with a negative family history who reported relatively severe life stress. These changes in amygdala reactivity with age occurred in the absence of clinical disorder or increases in depressive symptoms. CONCLUSIONS These results suggest that heightened amygdala reactivity emerges during adolescence, prior to the development of depression, as a function of familial risk or, in the absence of familial risk, stressful life events.
Strong Correlation Between Experiment and Simulation for Two-Photon Absorption Induced Carrier Generation

This correspondence comments on the correlation between measured and simulated charge collection in two diode structures presented in [1]. In [1], results from pulsed-laser-induced charge deposition via two-photon absorption revealed reasonable correlation between experimental data and simulations in some aspects but showed lack of correlation in terms of the measured and predicted magnitudes of the collected charge. The source of this poor agreement has recently been determined, and is attributed to an incorrect pulse energy calibration used for those experiments. With the proper energy calibration applied, the agreement between simulation and experiment is nearly quantitative for all observables in both devices. These results significantly strengthen the validity of the nonlinear optical beam propagation method numerical approach for accurately predicting pulsed-laser-induced charge deposition.
Diet specialization in an extreme omnivore: nutritional regulation in glucose‐averse German cockroaches

Organisms have diverse adaptations for balancing dietary nutrients, but often face trade‐offs between ingesting nutrients and toxins in food. While extremely omnivorous cockroaches would seem excluded from such dietary trade‐offs, German cockroaches (Blattella germanica) in multiple populations have rapidly evolved a unique dietary specialization – an aversion to glucose, the phagostimulant in toxic baits used for pest control. We used factorial feeding experiments within the geometric framework to test whether glucose‐averse (GA) cockroaches with limited access to this critical metabolic fuel have compensatory behavioural and physiological strategies for meeting nutritional requirements. GA cockroaches had severely constrained intake, fat and N mass, and performance on glucose‐based diets relative to wild‐type (WT) cockroaches and did not appear to exhibit digestive strategies for retaining undereaten nutrients. However, a GA × WT ‘hybrid’ had lower glucose aversion than GA and greater access to macronutrients within glucose‐based diets – while still having lower intake and survival than WT. Given these intermediate foraging constraints, hybrids may be a reservoir for this maladaptive trait in the absence of positive selection and may account for the rapid evolution of this trait following bait application.
THE EXTRAORDINARY TRILOBITE FENESTRASPIS (DALMANITIDAE, SYNPHORIINAE) FROM THE LOWER DEVONIAN OF BOLIVIA

Abstract: The hitherto poorly known, monotypic trilobite genus Fenestraspis from the Lower Devonian of Bolivia is revised and its original assignment to the Synphoriinae supported. The thoracic morphology of the genus remains very poorly known. Fenestraspis is morphologically unusual because of the development of extensive fenestrae in the pleural region of the pygidium and apparently of the thorax; the presence of upwardly directed spines on the cephalon, thorax and pygidium; and the exceptionally large and highly elevated eyes with the palpebral rim projecting outwards above the visual surface. The function of the fenestrae remains uncertain. If they formed openings in the body of the trilobite in life they may have allowed circulation of oxygenated water to the limb exites so that respiration could have been maintained while the trilobite was enrolled. If they were covered with a flexible membrane, they may have been secondary respiratory structures or had a sensory function. The Synphoriinae is regarded as a subfamily of the Dalmanitidae rather than as an independent family of the Dalmanitoidea as proposed by some authors. The type species of the poorly known monotypic genus Dalmanitoides from the Lower Devonian of Argentina is illustrated photographically for the first time and compared with Fenestraspis.
Analysis of the Devonian (Frasnian) platform from Belgium: a multi‐faceted approach for basin evolution reconstruction

This study undertakes a multi‐disciplinary approach (sedimentology, carbon isotopes, magnetic susceptibility and thickness distribution) to improve understanding of a major Palaeozoic carbonate platform, the Frasnian platform of Belgium. These combined techniques are used to reconstruct the platform history, which evolved in two main steps. During the first phase, the basin was strongly influenced by faulting, producing notable thickness and facies variations, with open ocean conditions, with good water circulation and no/or limited barrier reef. The second phase of platform development was less influenced by differential subsidence, as indicated by homogeneous facies distribution. However, this platform developed under restricted waters, with low circulation which is likely related to the development of a barrier reef.
Automatic Control of Distributed Systems Based on State Prediction Methods

Distributed systems have been developing rapidly in the past few years and their automatic control is a real challenge being a very active research field. In order to assure the load balancing and to optimize the resource utilization, a distributed system is using different software components, such as management tools, schedulers or monitoring tools. Considering the prediction of future behavior of distributed systems resources can offer better results in optimization and control. This paper proposes a state prediction algorithm based on neural networks using a genetic algorithm for initialization. The algorithm combines the advantages of the neural networks with the advantages of a dynamically constructed architecture and the very good results offered by a genetic algorithm. The prediction system includes the MonALISA monitoring system that collects information about the current status of the available resources in a distributed system. The algorithm is used in order to predict the next value or the next interval of values for parameters such as load, free memory or network bandwidth. The comparison between proposed algorithm and the classical prediction methods highlights the obtained improvements referring to the decreasing of the prediction errors.
The CURUPIRA-2 Block Cipher for Constrained Platforms: Specification and Benchmarking

Privacy is a key concern in Location Based Applications (LBAs), especially due to their intensive use resource constrained devices in which general purpose ciphers are di cult to deploy. In this paper, we address this issue by specifying a new, faster key-schedule algorithm for the Curupira block cipher. This special-purpose cipher follows the Wide Trail Strategy (such as AES) and is tailored for resource-constrained platforms, such as sensors and mobile devices. Furthermore, we present our benchmark results for both the Curupira-1 (which adopts the original key-schedule speci cation) and the Curupira-2 (which adopts the new one) in appropriate testbeds.
The nested assembly of plant–animal mutualistic networks

Most studies of plant–animal mutualisms involve a small number of species. There is almost no information on the structural organization of species-rich mutualistic networks despite its potential importance for the maintenance of diversity. Here we analyze 52 mutualistic networks and show that they are highly nested; that is, the more specialist species interact only with proper subsets of those species interacting with the more generalists. This assembly pattern generates highly asymmetrical interactions and organizes the community cohesively around a central core of interactions. Thus, mutualistic networks are neither randomly assembled nor organized in compartments arising from tight, parallel specialization. Furthermore, nestedness increases with the complexity (number of interactions) of the network: for a given number of species, communities with more interactions are significantly more nested. Our results indicate a nonrandom pattern of community organization that may be relevant for our understanding of the organization and persistence of biodiversity.
Autumn migration of robins (Erithacus rubecula) in Hungary

The purpose of this study was to describe the autumn migration dynamics of juvenile (n = 3075) and adult (n = 596) robin Erithacus rubecula in Hungary. Capturing and ringing of birds took place at five bird ringing stations of Actio Hungarica between 13 August and 27 October, 2004. The number of captured juvenile and adult individuals rated to one net was the lowest in the reeds of Izsák and the highest in the woody areas of Szalonna, where adults were present at a higher proportion. The migration dynamics of the robin showed that the end of September and the beginning of October was the peak time for passing through Hungary. Based on the estimated time of the 10% of daily capture, it can be stated that juvenile birds started their migration as early as the end of August or at the beginning of September while the migration of the adults started later. The migration started earliest in Szalonna and latest in Izsák. The comparison of daily catch dynamics (based on the estimated time of 10% and 50% of daily captures) of juveniles and adults between study sites showed that similarity of daily capture was higher in the case of juveniles. The five study sites had different qualities from the point of view of the robins’ habitat preference. Our results showed that the reed-bed of Izsák had only peripheral importance while the other forest and bushy study areas played a key role in resting and feeding during the migration of the robin.
Chinese Guidelines on the Diagnosis and Treatment of Melanoma (2015 Edition).

Malignant melanoma is one of the most common malignancies. Its incidence grows rapidly at an annual rate of 3−5%. Although the incidence of melanoma remains low in China, it has increased rapidly, with approximately 20,000 new cases reported each year. The mortality of melanoma also has been increasing rapidly; in contrast, although the incidence of melanoma is also increasing in western countries, its mortality basically remains unchanged and does not rise along with the escalation in prevalence. Thus, there is still a wide gap between China and Western countries in the diagnosis and treatment of melanoma. Melanoma has become one of the diseases that pose a major threat to health of Chinese people. However, compared with other common malignant tumors, there is still a far way to go to achieve the standardized diagnosis and treatment of melanoma. In May 2007, the Chinese Society of Clinical Oncology (CSCO) formally established the CSCO Melanoma Panel with an attempt to promote the development of clinical oncology, facilitate the multidisciplinary standardized treatment for melanoma, advocate the active learning and application of currently available scientific evidences at home and abroad, and explore the development of Chinese guidelines on the clinical practices on melanoma. After consultations with multidisciplinary experts, the first edition of the Chinese Consensus on the Diagnosis and Treatment of Melanoma was released in 2008; in 2009, 2011, and 2013, three revisions of this consensus document were published after many multidisciplinary seminars. The past 5 years have witnessed several breakthroughs in the clinical treatment of melanoma. Melanoma has become one of the malignant tumors whose treatment patterns have changed rapidly. To adapt to the fast advances in melanoma treatment and make the clinical management of melanoma in China more standardized and internationalized, the 2015 edition of the Chinese Guidelines on the Diagnosis and Treatment of Melanoma was finalized after repeated and wide consultations with multidisciplinary experts and updated and added with much new information, with an attempt to provide the up-to-dated and reliable instructions on clinical practices based recent scientific evidences.
An information theoretic approach to optimal amplifier operation

Amplifier performance can be severely degraded by the presence of intrinsic physical noise sources. We analyze the information transfer rates for simple and wide-range operational transconductance amplifiers (OTAs) using the principles of information theory. Frequency transfer characteristics and input-referred noise of both simple and wide-range OTAs are modeled using process dependent noise parameters to determine the frequency ranges of operation that provide minimum noise and maximum information capacity. The theoretical predictions of channel capacity are compared with empirical estimates of capacity determined using transfer characteristics and output noise obtained experimentally. The amplifiers have been fabricated in a commercially available 0.5mum process
Neogene and Quaternary Volcanism of Southeastern Turkey

Abstract Potassium-argon dating indicates two episodes of basaltic magmatism in south eastern Turkey at c. 19–15 and c. 2.3–0.6 Ma. Each produced olivine-titanaugite basalts, whose chemical compositions are difficult to classify using any conventional model in both the Anatolian continental fragment and the Arabian Platform. It is proposed here that both episodes of volcanism, and the associated crustal thickening and surface uplift, result from heating of the mantle lithosphere by crustal thickening caused by inflow of plastic lower crust from adjoining regions. Thus, although this study region has remained in a plate boundary zone for tens of millions of years, its volcanism has no direct relationship to local plate motions. It is suggested instead that both episodes of volcanism are the result of loading effects caused by glacial to interglacial sea-level variations, which will cause net flow of lower crust from beneath the offshore shelf to beneath the land: the moderate glaciations of Antarctica which began in the Early-Middle Miocene, and the more intense lowland glaciations of the northern hemisphere which began around c. 2.5 Ma.
Prediction of Consistency of Pituitary Adenomas by Magnetic Resonance Imaging

Abstract Objective Pituitary adenomas are typically soft. The prevalence of fibrous adenomas is ∼ 5 to 13%. Firm tumors are difficult to remove by curettage or suction. Predicting fibrous adenomas by magnetic resonance (MR) imaging is typically difficult and unreliable. We propose a new prediction method based on MR T2-sequence intensity. Methods The MRIs of 36 consecutive patients with nonsecreting macroadenomas were evaluated preoperatively by a blinded radiologist. Using an MR T2-weighted sequence, regions of interest were sampled from the adenoma and cerebellar peduncle, and the ratio was calculated. Intraoperatively, tumors were graded prospectively for their consistency by the operating surgeon. Results There were 28 soft and 6 fibrous tumors. Unpaired t test for these ratios was found to be statistically significant (p < 0.0240; 95% confidence interval, −0.8229 to −0.06207). Mean values for soft tumors were found to be 1.918 (standard error of the mean [SEM] = 0.08212); firm tumors, 1.475 (SEM = 0.1179). Soft tumors were associated with ratios > 1.5 (sensitivity 100%; specificity 66.7%); firm tumors were associated with ratios < 1.8 (sensitivity 100%; specificity 42.9%). Conclusion Fibrous adenomas are typically diagnosed intraoperatively. However, their resection can be technically challenging. Using T2 intensity ratios on routine preoperative MRI allows identification of these challenging cases. The surgeon can then be better prepared for the surgical resection.
A Review on Recent Developments in Fully Polarimetric SAR Image Despeckling

The use of synthetic aperture radar (SAR) technology with quad-polarization data requires efficient polarimetric SAR (PolSAR) speckle filtering algorithms. During the last three decades, many effective methods have been developed to reduce the speckle in PolSAR images, and recent studies have generally shown a trend developing from local single-point filtering to nonlocal patch-based or globally collaborative filtering. The main goals of this paper are to make a comprehensive review of the existing PolSAR despeckling algorithms and highlight the recent development trends. In the experimental part, the filtering results obtained with both simulated and real PolSAR images are deployed to compare the performance of some of the state-of-the-art despeckling algorithms, which shows that all of the selected filters have their individual strengths and weaknesses.
Site index prediction of Eucalyptus dunnii Maiden plantations with soil and site parameters in sub-tropical eastern Australia

1 Forestry Program, School of Environmental Science, Southern Cross University, Lismore, NSW 2480, Australia 2 Email: john.grant@scu.edu. au 3 Formerly Forests NSW, PO Box J19, Coffs Harbour Jetty, NSW 2450, Australia 4 Present address: Elders Forestry, PO Box 1581, Cairns, Queensland 4870, Australia 5 Present address: WA Forest Products Commission, Locked Bag 388, Perth Business Centre, WA 6849, Australia
Lead and Cadmium Levels and Balance and Vestibular Dysfunction among Adult Participants in the National Health and Nutrition Examination Survey (NHANES) 1999–2004

Background: Few studies have been conducted to identify risk factors for balance and vestibular dysfunction in general populations, but previous studies have reported evidence of adverse effects of lead and cadmium on balance control in high-risk groups. Objective: We evaluated the relationship between blood lead and cadmium levels and balance and vestibular dysfunction in a general population study. Methods: We analyzed data from the 1999–2004 National Health and Nutrition Examination Survey (NHANES) of 5,574 adults ≥ 40 years of age. Balance dysfunction was evaluated by the Romberg Test of Standing Balance on Firm and Compliant Support Surfaces, which examines the ability to stand unassisted using four test conditions to evaluate vestibular system, vision, and proprioception inputs that contribute to balance. Blood levels of lead and cadmium were measured by atomic absorption spectrometry. Associations were estimated using logistic regression models adjusted for potential confounders. Associations with time to loss of balance were estimated using adjusted Cox proportional hazard models. Results: The adjusted odds ratio (OR) for balance dysfunction in association with the highest quintile (3.3–48 µg/dL) versus the lowest quintile (< 1.2 µg/dL) of lead was 1.42 [95% confidence interval (CI): 1.07, 1.89]. The corresponding OR for cadmium (0.9–7.4 µg/L vs. < 0.2 µg/L) was 1.27 (95% CI: 1.01, 1.60). The adjusted hazard ratio for time to failure for the most physiologically challenging balance test among subjects with the highest vs. lowest quintiles of blood lead was 1.24 (95% CI: 1.04, 1.48). Cadmium levels were not associated with time to failure. Conclusions: Our findings suggest that blood lead and cadmium levels may be associated with balance and vestibular dysfunction in a general sample of U.S. adults.
Information theory and the earthquake frequency-magnitude distribution

Abstract A new frequency-magnitude relation consistent with an average magnitude 〈 m 〉 and an average seismic moment 〈 M o 〉 in the magnitude range ( m c , ω) is derived using the principles of information theory. The resulting density distribution n ( m ) dm = C exp{−λ 1 m − λ 2 M o ( m )} dm can be interpreted as a Boltzmann distribution of possible energy transitions scaled by a geometric factor, depending on how such transitions may occur on a fault plane. It gives a better fit to available frequency data on the Central Mediterranean area than other distributions which can only successfully model part of the magnitude range. The technique offers a direct method of including long-term geological information from plate models or observed fault movement in order to extrapolate seismicity statistics beyond the instrumental and historical eras. This approach is found to be in reasonable agreement with southern Californian frequency data—the resulting distribution being consistent with a geologically estimated recurrence time for the major events on the southern locked portion of the San Andreas fault.
Rapid Detection of Ophiostoma piceae andO. quercus in Stained Wood by PCR

ABSTRACT A rapid, sensitive, and simple method was developed to detect the sapstain fungi Ophiostoma piceae and O. quercus in stained wood. By using microwave heating for DNA extraction and PCR with internal transcribed spacer-derived-specific primers, detection was feasible within 4 h, even with DNA obtained from a single synnema. This method can easily be extended for the detection of other wood-inhabiting fungi.