Miracle-dz/UniFAR-FTUs huggingface dataset:
Retinal oximetry images must be standardized: a methodological analysis.

PURPOSE Retinal vessel oximetry is a new technology and needs detailed methodological scrutiny. We determine (1) the repeatability of retinal vessel oxygen saturation measurements, (2) whether measured saturation is different between retinal quadrants, and (3) whether the angle of gaze changes measurements of the same vessels. METHODS Fundus oximetry images were obtained from 26 healthy individuals, 18 to 30 years old, using the Oxymap retinal oximeter. Oxygen saturation in the same vessel segments was compared between two similar images of each individual to determine repeatability. Vessel oxygen saturation was also compared between different quadrants of the retina in the same oximetry image. Finally, oxygen saturation measurements were made on the same vessel segments at different angles of gaze. RESULTS Mean and standard deviation of saturation measurements was 93.1% ± 2.3% in arterioles and 64.9% ± 3.3% in venules. Standard deviation of repeated saturation measurements on the same vessel segment was 1.0% in arterioles and 1.4% in venules. Significant differences were seen between retinal quadrants. When angle of gaze was altered, measured saturation was lower in the same vessels when they were located in the inferior portion compared with other parts of the image (-1.3% ± 1.7%, P = 0.0004 in arterioles and -1.9 ± 2.4%, P = 0.0007 in venules). CONCLUSIONS Retinal vessel oxygen saturation measurements are repeatable with a small standard deviation. When oximetry results are compared between time points or eyes, the imaging must be standardized and similar parts of the images analyzed.
Big Five Personality Factors and Facets as Predictors of Openness to Diversity

ABSTRACT Openness to diversity is a crucial component of cultural competence needed in the increasingly diversified modern society and a necessary condition for benefitting from diversity contacts and interventions (e.g., diversity training, cultural courses). Responding to the recent call for more research on personality and its relation to diversity outcomes, we examined the associations between Big Five personality (i.e., Openness to Experience, Agreeableness, Extraversion, Neuroticism, and Conscientiousness) higher order factors and lower order facets and universal-diverse orientation (i.e., open attitude of appreciating human universality and diversity; Miville et al., 1999). In the Study 1 (N = 338) web survey on Big Five factors, Openness to Experience and Agreeableness were associated with universal-diverse orientation significantly. In the Study 2 (N = 176) paper survey on both Big Five factors and facets, Openness to Experience, low Neuroticism, and Conscientiousness, and various lower-order facets of all the Big Five personality were associated with universal-diverse orientation significantly. Practical implications were suggested on how personality facets could be incorporated into current diversity interventions to enhance their effectiveness of promoting openness to diversity.
Localized Short Elastic Tape Affects the Hamstring Reflex on Anterior Cruciate Ligament Deficient Knee (ナノ・サブマイクロ技術を用いた模擬/人工生体組織の創製と新診断・治療法の開発プロジェクト)

We evaluated the effect of localized continuous cutaneous stimulation on functional stability of the knee in a subject with an old anterior cruciate ligament (ACL) complete tear. Three controlled comparative experiments were performed: 1) without applying the cutaneous stimulation to deficient and uninjured knees, 2) with applying the stimulation to deficient knee, and 3) with applying the stimulation to deficient knee with subcutaneous anesthesia. For the cutaneous stimulation, we applied a short elastic tape (SET) on the lateral side of the knee, which did not immobilize the joint. We evaluated functional stability of the knee by measuring response latency of the stretch reflex in the hamstring muscle after acute anterior translation of the tibia. The latencies in ACL deficient and uninjured knees without applying SET were 66.7 ms and 43.4 ms, respectively. When SET was applied, the value in the deficient knee was shortened to 49.0 ms, and the value was prolonged to 58.5 ms after subcutaneous anesthesia. Our data indicate the possibility that continuous cutaneous stimulation to a small and localized area in ACL-deficient knee may improve the stretch reflex, which may contribute to the functional stability of the knee.
Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I

Synapsins are synaptic vesicle (SV)-associated proteins that regulate synaptic transmission and neuronal differentiation. At early stages, Syn I and II phosphorylation at Ser9 by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin-dependent protein kinase I/IV modulates axon elongation and SV-precursor dynamics. We evaluated the requirement of Syn I for synapse formation by siRNA-mediated knockdown as well as by overexpression of either its wild-type (WT) form or its phosphorylation mutants. Syn1 knockdown at 14 days in vitro caused a decrease in the number of synapses, accompanied by a reduction of SV recycling. Although overexpression of WT Syn I was ineffective, overexpression of its phosphorylation mutants resulted in a complex temporal regulation of synapse density. At early stages of synaptogenesis, phosphomimetic Syn I S9E significantly increased the number of synapses. Conversely, dephosphomimetic Syn I S9A decreased synapse number at more advanced stages. Overexpression of either WT Syn I or its phosphomimetic S9E mutant rescued the decrease in synapse number caused by chronic treatment with tetrodotoxin at early stages, suggesting that Syn I participates in an alternative PKA-dependent mechanism that can compensate for the impairment of the activity-dependent synaptogenic pathway. Altogether these results indicate that Syn I is an important regulator of synapse formation, which adjusts synapse number in response to extracellular signals.
The influence of direct supervision of resistance training on strength performance.

PURPOSE The purpose of this study was to compare changes in maximal strength, power, and muscular endurance after 12 wk of periodized heavy-resistance training directly supervised by a personal trainer (SUP) versus unsupervised training (UNSUP). METHODS Twenty moderately trained men aged 24.6 +/- 1.0 yr (mean +/- SE) were randomly assigned to either the SUP group (N = 10) or the UNSUP group (N = 8). Both groups performed identical linear periodized resistance training programs consisting of preparatory (10-12 repetitions maximum (RM)), hypertrophy (8 to 10-RM), strength (5 to 8-RM), and peaking phases (3 to 6-RM) using free-weight and variable-resistance machine exercises. Subjects were tested for maximal squat and bench press strength (1-RM), squat jump power output, bench press muscular endurance, and body composition at week 0 and after 12 wk of training. RESULTS Mean training loads (kg per set) per week were significantly (P < 0.05) greater in the SUP group than the UNSUP group at weeks 7 through 11 for the squat, and weeks 3 and 7 through 12 for the bench press exercises. The rates of increase (slope) of squat and bench press kg per set were significantly greater in the SUP group. Maximal squat and bench press strength were significantly greater at week 12 in the SUP group. Squat and bench press 1-RM, and mean and peak power output increased significantly after training in both groups. Relative local muscular endurance (80% of 1-RM) was not compromised in either group despite significantly greater loads utilized in bench press muscular endurance testing after training. Body mass, fat mass, and fat-free mass increased significantly after training in the SUP group. CONCLUSION Directly supervised, heavy-resistance training in moderately trained men resulted in a greater rate of training load increase and magnitude which resulted in greater maximal strength gains compared with unsupervised training.
Using Time Series Analysis to Measure Intermedia Agenda-Setting Influence in Traditional Media and Political Blog Networks

Using time series analysis to gauge intermedia agenda setting in a sample of eighteen U.S. political blogs, two elite traditional news entities, and their eleven political newsroom blogs across three issues in 2007, this study reveals that traditional media were unable to set political blog agendas. Ideologically diverse political blog networks were also able to set traditional media's online news agenda, and, to a lesser extent, their newsroom blog agenda. Findings point to a dilution of traditional media's singular agenda-setting influence and to greater interdependence between traditional media and political blogs than suggested by hyperlink studies.
Endothelin-1 and O2-Mediated Pulmonary Hypertension in Neonatal Rats: A Role for Products of Lipid Peroxidation

We hypothesized that reactive O2 species, or their intermediary products, generated during exposure to elevated O2 lead to pathologic endothelin-1 expression in the newborn lung. Endothelin-1 expression and 8-isoprostane content (an in vivo marker of lipid peroxidation) were examined and found to be elevated (p < 0.05) in the lungs of newborn rats with abnormal lung morphology and pulmonary hypertension, as assessed by right ventricular hypertrophy, after a 14-d exposure to 60% O2. The antioxidant and lipid hydroperoxide scavenger, U74389G (10 mg/kg), given by daily i.p. injection prevented O2-dependent right ventricular hypertrophy (p < 0.05 compared with vehicle-treated controls), but had no effect on abnormal lung morphology. Additionally, we observed that 8-isoprostane caused marked endothelin-1 mRNA up-regulation in vitro in primary rat fetal lung cell cultures. We conclude that reactive O2 species, or their bioactive intermediaries, are causative in O2-mediated pulmonary hypertension and endothelin-1 up-regulation. It is likely that the bioactive lipid peroxidation product, 8-isoprostane, plays a key role in pathologic endothelin-1 expression and pulmonary hypertension during oxidant stress.
Structural Validity of the Wechsler Intelligence Scale for Children–Fifth Edition: Confirmatory Factor Analyses With the 16 Primary and Secondary Subtests

The factor structure of the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V; Wechsler, 2014a) standardization sample (N = 2,200) was examined using confirmatory factor analyses (CFA) with maximum likelihood estimation for all reported models from the WISC-V Technical and Interpretation Manual (Wechsler, 2014b). Additionally, alternative bifactor models were examined and variance estimates and model-based reliability estimates (&ohgr; coefficients) were provided. Results from analyses of the 16 primary and secondary WISC-V subtests found that all higher-order CFA models with 5 group factors (VC, VS, FR, WM, and PS) produced model specification errors where the Fluid Reasoning factor produced negative variance and were thus judged inadequate. Of the 16 models tested, the bifactor model containing 4 group factors (VC, PR, WM, and PS) produced the best fit. Results from analyses of the 10 primary WISC-V subtests also found the bifactor model with 4 group factors (VC, PR, WM, and PS) produced the best fit. Variance estimates from both 16 and 10 subtest based bifactor models found dominance of general intelligence (g) in accounting for subtest variance (except for PS subtests) and large &ohgr;-hierarchical coefficients supporting general intelligence interpretation. The small portions of variance uniquely captured by the 4 group factors and low &ohgr;-hierarchical subscale coefficients likely render the group factors of questionable interpretive value independent of g (except perhaps for PS). Present CFA results confirm the EFA results reported by Canivez, Watkins, and Dombrowski (2015); Dombrowski, Canivez, Watkins, and Beaujean (2015); and Canivez, Dombrowski, and Watkins (2015).
[Lid-wiper epitheliopathy in patients with dry eye symptoms].

PURPOSE Lid-wiper epitheliopathy (LWE) is characterized by one part of the marginal conjunctiva of the upper eyelid being affected and is correlated with dry eye symptoms. This is a study of the clinical features of LWE. METHODS Three hundred and sixty-four eyes of 182 patients with dry eye symptoms were studied. In all subjects the presence of LWE was determined by lissamine green staining followed by tests for dry eye. RESULTS LWE was detected in 48 of 364 eyes (13.2%). One hundred thirty-four eyes were diagnosed with dry eye and LWE was detected in 25 of 134 eyes (18.7%). This rate was higher than that of non-dry eyes with LWE (23 of 230 eyes, 10.0%). Since LWE was detected at a high rate in contact lens (CL) wearers (22 of 37 eyes, 59.4%), LWE background factors in CL wearers and non-CL wearers were compared. Significantly higher fluorescein staining scores were detected in the LWE positive CL wearers compared to LWE negative CL wearers, whereas no significant differences were detected between the LWE positive and negative groups in any other dry eye examination. LWE-like lissamine green staining was detected on the lower eyelids in 122 eyes (33.0%). CONCLUSION LWE was detected in more than 10% of patients with dry eye symptoms. Although LWE was detected in dry eye patients, no clear relationship was recognized between LWE and the presence of dry eye.
Craving Is an Affective State and Its Regulation Can Be Understood in Terms of the Extended Process Model of Emotion Regulation

We argue that craving is an affective state per the definition offered in the target article, and as such the Extended Process Model provides a strong theoretical framework to understand the self-regulation of craving. First, we briefly define craving in general and food craving in particular and relate those constructs to the definitions of affect and emotion in the target article. We then apply the Extended Process Model to cognitive strategies for self-regulation of food craving and related clinical interventions. In doing so, we illustrate how the Extended Process Model of Emotion Regulation is a useful tool for bridging related topics within affective science (e.g., craving and emotion) and for analyzing and improving programs that target affective states (e.g., dietary interventions).
Long-term Benzodiazepine Treatment in Patients with Psychotic Disorders Attending a Mental Health Service in Rural Greece

Introduction: Long-term benzodiazepine (BZD) treatment in patients with mental disorders is widespread in clinical practice, and this is also the case of patients with schizophrenia, although the evidence is weak and BZD prescription is discouraged by guidelines and medical authorities. Data on BZD prescription are usually derived from national or regional databases whereas information on the use of BZD by patients with schizophrenia and related psychoses in general population-based samples is limited. Materials and Methods: Information for 77 patients with psychotic disorders who were regularly attending follow-up appointments with the multidisciplinary Mobile Mental Health Unit of the prefectures of Ioannina and Thesprotia, Northwest Greece, during 1-year period (2015) was obtained from our database. Results: From the total of 77 engaged patients, 30 (39%) were regularly prescribed BZDs in the long term, as part of their treatment regimen. Prescribed BZDs were mostly diazepam and lorazepam, in 43.3% of cases each. The mean daily dose of these compounds was 13 mg and 3.77 mg, respectively. Statistical analysis showed a correlation of long-term BZD use with the history of alcohol/substance abuse. Most patients were receiving BZD continuously for several years, and the mean dose was steady within this interval. Conclusions: A large proportion of patients with psychotic disorders were regularly prescribed BZD in long term. It appears that when BZDs are prescribed for some period in the course of a psychotic disorder, their use commonly exceeds the recommended interval and then becomes a regular part of the chronic treatment regimen. Future research should address the factors that may be related to the long-term BZD use by patients with psychotic disorders. Interventions for the reduction of regular BZD prescription should target the primary care setting and all those who treat first episode patients.
Carl Rogers' Person-centered Approach: Toward an understanding of its implications

1. Approaching the Approach: An introduction2. The Person-Centered Approach to Psychotherapy3. The Person-Centered Approach to Small Groups: More than psychotherapy4. Applying the Person-Centered Approach vs. Applying the Principles of Client-Centered Therapy5. An Example of the Pitfalls in 'Giving People an Experience of the Person-Centered Approach' Instead of Applying the Approach6. The Person-Centered Approach to Large Group Workshops 7. A Rehearsal for Understanding the Phenomenon of Group8. Learning About Learning 9. Effect of Group10.On Becoming a Culture11. What's Wrong With the Psychology of Client-Centered Therapy? 12. Toward a Psychology for Applications of the Person-Centered Approach
A D-Band Gain-Boosted Current Bleeding Down-Conversion Mixer in 65 nm CMOS for Chip-to-Chip Communication

A D-band gain-boosted current-bleeding down-conversion mixer is presented in this letter using 65 nm CMOS technology. The proposed downconversion mixer uses a gain-boosted current-bleeding technique to improve the conversion gain for low power chip to chip communication with a low local oscillator (LO) power. Broadband Marchand baluns were used to transform a single-ended signal to a differential signal at the RF and LO port for measurement. According to experimental results, the proposed mixer had a measured conversion gain of -12 ± 1 dB at a frequency range from 113 to 127 GHz with an ultra-low LO power of -9 dBm using a gain-boosted current bleeding technique. The LO-to-RF isolation was better than -30 dB. This core chip occupies 350 × 320 μm2. The power consumption is 6 mW from a 1 V supply voltage.
Hepatitis C virus and Human Immunodeficiency Virus coinfection among attendants of Voluntary Counseling and Testing Centre and HIV follow up clinics in Mekelle Hospital

Introduction Hepatitis C virus remains a large health care burden to the world. HIV and HCV coinfection is major global health concern worldwide. However, there is limited information on the prevalence of HCV/HIV co-infection in Ethiopia. The aim of the study was to assess the magnitude of HIV/HCV coinfection and the potential risk factors in attendants of voluntary counseling and testing centre and HIV follow up clinics of Mekelle hospital. Methods A cross sectional seroprevalence survey of HCV infection was carried out on 300 HIV negative and positive subjects attending voluntary counseling and testing (VCT) center and HIV follow up clinics of Mekelle hospital, Ethiopia from December 2010-February 2011. Serum samples were tested for anti-HCV antibodies using immunochromatographic test. Results Of the 300 study participants, 126(42%) were HIV negative and 174(58%) HIV seropositive from VCT and HIV follow up clinics, respectively. The overall anti-HCV prevalence was 18(6.0%). There were no significant differences in HCV seroprevalence among the different categories of age and sex (p> 0.05). Of the 174 persons with HIV, 16 (9.2%) cases had antibodies to HCV, where as among 126 HIV negative subjects 2 (1.58%) were HCV seropositive (p= 0.006, OR= 6.28, 95% CI= 1.42-27.82). Conclusion Accordingly, there was a significant difference in sero-positivity of HCV between HIV positive and HIV negative participants. No apparent risk factor that caused HCV infection was inferred from this study.
Comparison of the Laminar Distribution of Input from Areas 17 and 18 of the Visual Cortex to the Lateral Geniculate Nucleus of the Cat

The feedback from area 18 of the cat visual cortex to the lateral geniculate nucleus has been investigated by labeling and reconstructing seventeen axons of known receptive field position and eye preference. The distribution of boutons from each axon was quantified with respect to the compartments of the geniculate complex, and the results were compared with an equivalent analysis of fourteen area 17 axons. Area 18 axons form large, sparse arborizations that extend up to 1.9 mm laterally (1170 ± 85 μm; mean ± SEM), with a core of relatively dense innervation spanning on average 600 ± 70 μm (mean ± SEM). Thus, they have the potential to influence the transmission of visual information from well beyond their own classical receptive fields. In this respect, they are surprisingly similar to the axons from area 17, despite the fact that the two cortical areas have very different retinotopy. However, there are important differences between the pathways. Area 18 axons project more heavily to the C layers and medial interlaminar nucleus. Whereas the input from both areas to the A layers is biased toward the layer appropriate to the eye preference of each axon, the area 18 input to magnocellular layer C is not. The distribution of area 18 boutons favors the bottom of their preferred A layer, and the area 17 boutons favor the top. These differences mirror those seen in the afferent pathways, suggesting that each cortical area preferentially targets the cells from which it receives input. Finally, their greater diameter suggests that area 18 axons provide the earliest feedback signal in the corticogeniculate loop.
Variations in EEG Coherence as an Index of the Affective Content of Dreams from REM Sleep: Relationships with Face Imagery

EEG coherence was examined in relation to four measures of socioemotional dream content, including a new measure--the proportional representation of a character's face. Twenty-four healthy subjects, recorded for sleep stages and EEG activity, were awakened from REM sleep to report dream mentation and to rate it on these variables. Coherence scores were calculated for homologous interhemispheric electrode pairs (Fp1-Fp2, F3-F4, F7-F8, C3-C4, P3-P4, O1-O2, T3-T4, T5-T6) and for left and right intrahemispheric pairs for delta, theta, alpha, beta1, and beta2 frequencies. These were correlated with the mentation measures. Positive correlations were found between average interhemispheric coherence in most bands and the character face measure. A breakdown by gender revealed that this relationship was most evident for women, whereas for men positive correlations were observed between coherence and negative self-feeling. That similar relationships also obtained for both left and right intrahemispheric coherence is consistent with the hypothesis that dreamed socioemotional interactions reflect the integrative functioning of many brain regions in both hemispheres.
A Multi-Factor QoE Model for Adaptive Streaming over Mobile Networks

In the context of HTTP Adaptive Streaming (HAS), a main challenge is how to evaluate the quality of experience (QoE) of a session. In general, the QoE of a streaming session is affected by three key factors, namely initial delay, varying perceptual quality, and interruptions. In this paper, in order to investigate the impacts of quality variations and interruptions on the QoE of a session, we propose to use histograms, which represent the frequency distributions of these recurrent factors in a session. The QoE of a session is modeled by pooling the statistics of the recurrent factors and the initial delay. Evaluation results show that the proposed model has a high prediction performance. Especially, the proposed model provides insights into the impacts of different influence factors, thus leading to suggestions to improve the quality of streaming video.