Miracle-dz/UniFAR-FTUs huggingface dataset:
Psoriasis and pustular dermatitis triggered by TNF-{alpha} inhibitors in patients with rheumatologic conditions.

BACKGROUND New onset or worsening of psoriasis has been reported in patients treated with tumor necrosis factor alpha (TNF-alpha) inhibitors for a variety of rheumatologic conditions. There is mounting evidence that a key innate immune pathway for triggering common human autoimmune disease, including psoriasis, involves plasmacytoid dendritic cell precursors (PDCs) and type 1 interferon (IFN) production. We present herein a case series with clinical and histopathologic evidence of psoriasis in patients with rheumatologic disease treated with TNF-alpha inhibitors. We propose that the cross regulation between TNF-alpha and IFN may have a role in the pathogenesis of this reaction. OBSERVATIONS We observed new-onset psoriasis (n = 13) or severe exacerbation of psoriasis (n = 2) in 15 patients with a variety of rheumatologic conditions-rheumatoid arthritis (n = 13), psoriatic arthritis (n = 1), and seronegative arthritis (n = 1)-during treatment with etanercept (n = 6), infliximab (n = 5), and adalimumab (n = 4). Immunohistochemical staining of skin biopsy specimens for myxovirus-resistance protein A (MxA, a surrogate marker for lesional type 1 IFN activity) showed increased staining in TNF-alpha inhibitor-induced psoriasis compared with psoriasis vulgaris. CONCLUSIONS New onset or severe exacerbation of psoriasis is a rare complication of TNF-alpha inhibitor therapy. The finding of increased production of IFN-alpha in TNF-alpha inhibitor-induced psoriasis is a possible pathophysiologic explanation for this reaction.
The role of pulse duration and stimulation duration in maximizing the normalized torque during neuromuscular electrical stimulation.

STUDY DESIGN Controlled laboratory study OBJECTIVES To determine the effects of pulse duration and stimulation duration on the evoked torque after controlling for the activated area by using magnetic resonance imaging (MRI). BACKGROUND Neuromuscular electrical stimulation (NMES) is commonly used in the clinic without considering the physiological implications of its parameters. METHODS AND MEASURES Seven able-bodied, college students (mean +/- SD age, 28 +/- 4 years) participated in this study. Two NMES protocols were applied to the knee extensor muscle group in a random order. Protocol A applied 100-Hz, 450-microsecond pulses for 5 minutes in a 3-seconds-on 3-seconds-off duty cycle. Protocol B applied 60-Hz, 250-microsecond pulses for 5 minutes in a 10-seconds-on 20-seconds-off duty cycle. The amplitude of the current was similar in both protocols. Torque, torque time integral, and normalized torque for the knee extensors were measured for both protocols. MRI scans were taken prior to, and immediately after, each protocol to measure the cross-sectional area of the stimulated muscle. RESULTS The skeletal muscle cross-sectional areas activated after both protocols were similar. The longer pulse duration in protocol A elicited 22% greater torque output than that of protocol B (P<.05). After considering the activated area in both protocols, the normalized torque with protocol A was 38% greater than that with protocol B (P<.05). Torque time integral was 21% greater with protocol A (P = .029). Protocol B failed to maintain torque at the start and the end of the 10-second activation. CONCLUSIONS Longer pulse duration, but not stimulation duration, resulted in a greater evoked and normalized torque compared to the shorter pulse duration, even after controlling for the activated muscular cross-sectional areas with both protocols. LEVEL OF EVIDENCE Therapy, level 5.
Fate and Developmental Effects of Dietary Uptake of Methylmercury in Silurana tropicalis Tadpoles

Adverse effects of methylmercury (MeHg) exposure during amphibian metamorphosis remain to be fully characterized. Most previous investigations determined effects of short-term exposure to elevated dose rates, without information on mercury (Hg) depuration and degradation pathways. Since metamorphosis is primarily controlled by thyroid hormones (TH), alterations in this process suggest a disruption of the TH endocrine axis. The aim of this research was to (1) characterize patterns of MeHg accumulation and depuration in tadpoles and (2) examine effects of MeHg accumulation on metamorphosis and the TH axis. Silurana tropicalis tadpoles were exposed to environmental levels of dietary MeHg until metamorphic climax. Whole-body MeHg and total Hg (THg) levels were measured, as well as the number of metamorphs, rate of metamorphosis, body size, and whole-body triiodothyronine (T3) levels at metamorphosis. Tadpoles exposed to a higher level of MeHg exhibited increased mortality and size, and reduced metamorphosis. At lower levels of MeHg, body burdens increased rapidly and eventually reached a plateau, whereas no plateau was reached at a higher level of MeHg exposure. T3 levels were not affected. Data indicate that at low and medium levels of exposure, depuration of MeHg may prevent toxicity in tadpoles. However, depuration mechanisms may be insufficient at high doses, producing disruption of metamorphosis and death. Although there were no marked effects of MeHg on whole-body T3 levels, further investigation of other components of the TH axis is warranted.
12D-1 Excitation of Longitudinal and Lamb Waves in Plates by Edge-Mounted Transducers

Lamb waves have been extensively studied for the detection of flaws in plate-like structures. However operation at low f-d products is usually recommended in order to eliminate the complications of multiple Lamb modes, and low f-d products lead to reduced scattering from small defects. Here we explore the generation of waves at higher f-d products. We explore the transition between the generation of multiple Lamb modes and the generation of a train of nearly longitudinal pulses. We also investigate the transfer of energy from the leading to trailing pulses along with the scattering of the pulse train by simulated defects.
Discourse, Dominance and Power Relations

This article focuses on some of the issues that arise when examining social inequality and similar notions such as dominance or group superiority as participants’ concerns. It emphasizes the importance of understanding constructions of inequality in terms of how they are (1) situated, constructed and invoked in talk; and (2) oriented to and part of actions and ideological practices. These concerns are illustrated with an example from an interview with majority group members on ethnic issues. This shows how particular orientations to and descriptions of inequality are constructed and what they might be doing. Implications for the study of the discursive construction and representation of social inequality in talk and the nature of inequality as an object in interaction are discussed.
Closeness, Expenditures, and Turnout in the 1982 U.S. House Elections

Students of elections have repeatedly found that the closeness of an election is modestly correlated with turnout. This may be due to a direct response of instrumentally motivated voters, but recent theoretical work casts doubt on the adequacy of this explanation. Another possibility is that elite actors respond to closeness with greater effort at mobilization. We explore the latter possibility by using FEC and state data on campaign expenditures in House, Senate, and gubernatorial races. Our results indicate that closeness has an effect at both the mass and elite levels. We also provide quantitative estimates of the effect of Senate and gubernatorial expenditure on House turnout.
iRNA and tropism of human parvovirus B 19

Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation
Use of whey as a culture medium for Bacillus clausii for the production of protein hydrolysates with antimicrobial and antioxidant activity

The use of whey as a natural culture medium to produce hydrolysates with antimicrobial from Bacillus clausii is the objective of this research. The fermentation process was carried out at 25 ℃ for five days, where proteolytic activity, soluble peptides quantification, and antimicrobial activity using the disc diffusion method were determined every day. The fermented whey reached values of proteolytic activity between 90 and 260 U ml−1 and a production of soluble peptides between 100 and 2070 µg ml−1. The maximum values were reached after three days of fermentation to all determinations. In addition, the inhibition zone of fermented whey against Salmonella Typhimurium, Escherichia coli, Shigella flexneri, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis strains were 13.7, 13.2, 14.4, 14.6, 9.8, 15.7 mm, respectively. The hydrolysates inhibited the 2, 2’-azinobis (3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radicals by 85 and 80%, respectively. The whey was used to allow the growth of B. clausii and to generate peptides with antioxidant and antimicrobial activity through the hydrolysis of proteins present in the natural culture medium. This process could be used for the development of new dairy products added with probiotics.
Who is Being Served? The Impact of Student Volunteering on Local Community Organizations

This research investigated how local community-based and nonprofit organizations benefit from cooperation with community-based learning (CBL) initiatives such as service learning, internships, and volunteering. By examining data from local organizations that cooperate with a campus-based student volunteer program, the authors empirically assessed the extent to which local organizations benefit from cooperation with CBL initiatives. The data enabled comparisons of the relative contributions of university student volunteers and off-campus volunteers recruited from the larger community. The authors found that student volunteers constitute a substantial pool of volunteer labor for local organizations, yet they play different roles than community volunteers, roles that vary by organizational form. Student volunteers are generally the least likely to provide or help plan and coordinate services compared with community volunteers. These differences can be offset by a modest amount of training for student volunteers. The findings do not support the notion that students are used exclusively for routine tasks.
Investigating the receptive vocabulary size of university-level Chinese learners of English: how suitable is the Vocabulary Levels Test?

The Vocabulary Levels Test (VLT) is widely used to assess the vocabulary size of second-language learners of English. The test assesses learners' knowledge of words of different frequencies within general English and of high-frequency words within academic texts. We used the VLT to measure the English vocabulary size of Chinese university students of English in Hong Kong where a large vocabulary is required for academic and professional success. Students achieved high scores for high-frequency words but scored poorly for low-frequency words. We consider the possibility that the low scores reflect a deficit of the test: words were selected on the basis of frequency counts from dated word lists of American words and at the lower frequency levels may not be representative of current Hong Kong English. We compiled a corpus of 14.7 million words of Hong Kong English. Cross-checking revealed a number of VLT words that do not occur in the corpus. We argue that these words are not required by English speakers in Hong Kong and that the lowest word frequency levels of the VLT should be revised to reflect modern Hong Kong English.
The Epidemiology of Sleep Quality and Consumption of Stimulant Beverages among Patagonian Chilean College Students

Objectives. (1) To assess sleep patterns and parameters of sleep quality among Chilean college students and (2) to evaluate the extent to which stimulant beverage use and other lifestyle characteristics are associated with poor sleep quality. Methods. A cross-sectional study was conducted among college students in Patagonia, Chile. Students were asked to complete a self-administered questionnaire to provide information about lifestyle and demographic characteristics. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality. In addition, students underwent a physical examination to collect anthropometric measurements. Results. More than half of students (51.8%) exhibited poor sleep quality. Approximately 45% of study participants reported sleeping six hours or less per night and 9.8% used medications for sleep. In multivariate analysis, current smokers had significantly greater daytime dysfunction due to sleepiness and were more likely to use sleep medicines. Students who reported consumption of any stimulant beverage were 1.81 times as likely to have poor sleep quality compared with those who did not consume stimulant beverages (OR:1.81, 95% CI:1.21–2.00). Conclusions. Poor sleep quality is prevalent among Chilean college students, and stimulant beverage consumption was associated with the increased odds of poor sleep quality in this sample.
Hybrid MPI/OpenMP implementation of PCA

Most surveillance systems depend on fully automated face recognition applications. The main concern is achieving high accuracy in real time. Principle Component Analysis algorithm is used for reducing the number of variables and getting the maximum variance between low dimensional data. The proposed approaches focus on data partitioning to minimize the execution time of the algorithm by distributing data over a cluster with parallel computing architecture. The first approach achieves 2975X and 102X relatively faster than the sequential implementation in the training and recognition phases, respectively. However, the second approach achieves 74X relatively faster than the sequential implementation in the recognition phase.
Immediate implants following tooth extraction. A systematic review

Objectives: The aim of this article is to review the current state of immediate implants, with their pros and contras, and the clinical indications and contraindications. Material and Methods: An exhaustive literature search has been carried out in the COCHRANE library and MEDLINE electronic databases from 2004 to November 2009. Randomized clinical trials and clinical trials focused on single implants placed in fresh extraction sockets were included and compared. A meta-analysis could not be performed due to heterogeneity of the data. Results: Twenty studies out of 135 articles from the initial search were finally included, which summed up a total of 1139 immediate implants with at least a 12-month follow-up. Our results have been compared with other current available papers in the literature reviewed that obtained similar outcomes. Discussion: Immediate implants have predictable results with several advantages over delayed implant placement. However, technical complications have been described regarding this technique. Also, biomaterials may be needed when the jumping distance is greater than 1mm or any bone defect is present. Conclusions: Few studies report on success rates rather than survival rates in the literature reviewed. Short-term clinical results were described and results were comparable to those obtained with delayed implant placement. Further long-term, randomized clinical trials are needed to give scientific evidence on the benefits of immediate implants over delayed implant placement. Key words:Immediate implants, fresh socket, dental implants, gap, jumping distance, implant stability.
The use of augmentative and alternative communication apps for the iPad, iPod and iPhone: an overview of recent developments

Purpose – The purpose of this paper is to provide an overview of the communication applications (apps) that can be used with devices such as the iPad, iPod and iPhone to support augmentative and alternative communication (AAC). Design/methodology/approach – A brief discussion of the research into the use of high‐technology communication aids is followed by an introduction to the iPad, iPod and iPhone AAC apps.Findings – These devices and apps clearly have a role within the spectrum of AAC devices currently available. They may have some distinct advantages in cost, ease of use and acceptability but more research into their use is needed.Originality/value – This article starts with a model of communicative competence and presents some recent research into barriers in the use of high‐technology AAC. It suggests some ways in which AAC apps may address some of the barriers to implementation and functional use. Finally, the need for individual assessment to determine specific communication needs is stressed. The.
A laparoscopic versus open adrenalectomy in Ramathibodi Hospital.

OBJECTIVE To compare the results of laparoscopic adrenalectomy with those of open adrenalectomy in Ramathibodi Hospital. MATERIAL AND METHOD Medical charts of 41 laparoscopic and 39 open adrenalectomy patients were reviewed Baseline characteristics and outcomes of treatment were compared between these two patient groups, using univariable statistical tests and multivariable statistical procedures. RESULTS There were significant baseline differences between the two groups in terms of gender, body mass index, ASA class, and preoperative diagnosis. The outcomes operative time, estimated blood loss and length of hospital stay were also significantly different. After adjusting for the effects of baseline differences, laparoscopic adrenalectomy was associated with a significant reduction of length of hospital stay by 40%. CONCLUSION Laparoscopic adrenalectomy is a safe and effective procedure and should help hasten postoperative recovery and may save the costs of hospitalization.
The mediatisation of religion: Theorising religion, media and social change

Drawing on recent advances in mediatisation theory, the article presents a theoretical framework for understanding the increased interplay between religion and media. The media have become an important, if not primary, source of information about religious issues, and religious information and experiences become moulded according to the demands of popular media genres. As a cultural and social environment, the media have taken over many of the cultural and social functions of the institutionalised religions and provide spiritual guidance, moral orientation, ritual passages and a sense of community and belonging. Furthermore, the article considers the relationship between mediatisation and secularisation at three levels: society, organisation and individual. At the level of society, mediatisation is an integral part of secularisation. At the level of organisation and the individual, mediatisation may both encourage secular practices and beliefs and invite religious imaginations typically of a more subjectivised nature.
Using Estimated Models to Assess Nominal and Real Rigidities in the United Kingdom

This paper aims to contribute to our understanding of inflation dynamics in the United Kingdom by estimating two dynamic stochastic general equilibrium models and assessing the role of nominal and real rigidities within them. We first obtain an empirical representation of the monetary transmission mechanism in the United Kingdom and then estimate the models by minimising the difference between this representation and its model equivalents. We find that both models can explain the data reasonably well without relying on undue amounts of price and wage stickiness.
A longitudinal follow-up of 550 mild cognitive impairment patients: evidence for large conversion to dementia rates and detection of major risk factors involved.

The most recent studies about mild cognitive impairment (MCI) are focused on the search for factors that make patients more vulnerable to conversion to dementia, mainly Alzheimer’s disease (AD). The aim of this study was to determine which neuropsychological test performances, including episodic memory profiles, and genetic risk factors (APOE ε4) better predict early conversion to dementia among the four MCI subtypes. Data from 550 MCI patients were analyzed for the purpose of this study and were classified according to Petersen’s criteria (2004), and also taking into account the absence (probable MCI) or presence (possible MCI) of comorbidities that could explain cognitive deficits. MCI cases were divided into Probable amnestic (Pr-aMCI) (n = 115), probable non-amnestic (Pr-naMCI) (n = 37), possible amnestic (Pss-aMCI) (n = 234), and possible non-amnestic (Pss-naMCI) (n = 164), single or multiple domain. In the whole MCI sample, regression analysis showed that low performances on Orientation, Verbal Delayed Recall of the Word List Learning test from WMS-III, and Luria’s Clock test were associated with conversion to dementia, independently of APOE ε4 allele. Cox proportional-hazards showed that the Probable MCI subtype, presence of storage memory impairment, multiple domain condition, and presence of at least one ε4 allele increased the risk of conversion to dementia. Multivariate survival and Kapplan-Meier analyses showed that the Pr-aMCI with storage memory impairment had the most and closest risk of conversion to dementia. In conclusion, the Pr-aMCI subset of patients had 8.5 times more risk of converting to dementia than the Pss-naMCI group, who displayed the slowest conversion rate to dementia.
Understanding Uncertainties in Future Colorado River Streamflow

The Colorado River is the primary water source for more than 30 million people in the United States and Mexico. Recent studies that project streamf low changes in the Colorado River all project annual declines, but the magnitude of the projected decreases range from less than 10% to 45% by the mid-twenty-first century. To understand these differences, we address the questions the management community has raised: Why is there such a wide range of projections of impacts of future climate change on Colorado River streamflow, and how should this uncertainty be interpreted? We identify four major sources of disparities among studies that arise from both methodological and model differences. In order of importance, these are differences in 1) the global climate models (GCMs) and emission scenarios used; 2) the ability of land surface and atmospheric models to simulate properly the high-elevation runoff source areas; 3) the sensitivities of land surface hydrology models to precipitation and temperature changes; .