Miracle-dz/UniFAR-FTUs huggingface dataset:
[Breeding places and biting activity of Anopheles species in the municipality of Cimitarra, Santander, Colombia].

INTRODUCTION Forty five percent of malaria cases in the department of Santander, Colombia originate in the municipality of Cimitarra. This locality has reported cases from the rural and urban areas. The population between 15 and 45 years of age is the most affected. Additionally, Cimitarra has registered malaria cases in children under 1 year of age. OBJECTIVE To determine the biology and behavioral aspects of Anopheles mosquitoes from Cimitarra to more effectively orient control strategies. MATERIALS AND METHODS During October to December/2002 and March/2003, anopheline collections were undertaken. Isofamilies were obtained from 620 wild females. RESULTS The following species were found in order of abundance: Anopheles (Nyssorhynchus) triannulatus (Neiva y Pinto 1922), Anopheles (Nyssorhynchus) nuneztovari Gabaldón 1940, Anopheles (Nyssorhynchus) rangeli Gabaldón, Cova-García y López 1940, Anopheles (Anopheles) pseudopunctipennis Theobald 1901, Anopheles (Anopheles) mattogrosensis Lutz y Neiva 1911 and Anopheles (Anopheles) neomaculipalpus Curry 1933. The highest biting rate (0.5) was recorded for An. nuneztovari and An. triannulatus indoors between 20-21 hours. Forty two breeding places were sampled, 81% were fish ponds, 9.5% puddles and 2.3% cement tanks. Eighty seven percent of fish ponds were located near dwellings, being positive for anopheline larvae. CONCLUSION This study has shown that in Cimitarra cryptic and sister species of Anopheles genus occur in sympatry, Nyssorhynchus subgenera.
Sustained Relief of Leiomyoma Symptoms by Using Focused Ultrasound Surgery

OBJECTIVE: To assess several measures of the long-term outcome of magnetic resonance–guided focused ultrasound surgery for symptomatic uterine leiomyomata. METHODS: Data on 359 women completing 24-month follow-up in all clinical trials of magnetic resonance–guided focused ultrasound surgery for uterine leiomyomata were analyzed. Quality of life outcomes, measured by the symptom severity score of the Uterine Fibroid Symptoms Quality Of Life Questionnaire were assessed for 24 months after treatment. Clinical endpoints, including uterine shrinkage, the need for additional leiomyoma treatment, and the time to additional leiomyoma treatment, were all assessed. The nonperfused volume ratio after treatment, calculated from the gadolinium-enhanced magnetic resonance imaging after treatment and the best measure of tissue necrosis after treatment, was used to assess outcome based on completeness of leiomyoma ablation. RESULTS: Women undergoing magnetic resonance–guided focused ultrasound surgery for symptomatic uterine leiomyomata have durable symptom relief, as measured by the symptom severity score at 24 months, with significantly greater improvement with more complete ablation (P<.001). Survival analysis demonstrates a significant reduction in the percentage of women undergoing additional leiomyoma treatment (P=.001) in women in the high nonperfused volume group. The mean shrinkage and mean residual nonperfused volume ratio are both significantly above zero at 6 months in the high nonperfused volume group (P<.001). The incidence of adverse events is low. However, for women with minimal treatment, the risk of additional procedures is high. CONCLUSION: Magnetic resonance–guided focused ultrasound surgery is an effective treatment for uterine leiomyomata and results in sustained symptomatic relief. LEVEL OF EVIDENCE: III
Regional Analgesia Following Epidural Blood Patch

During the period November 1972 through October 1974, 118 epidural blood patch procedures were performed for severe postlumbar-puncture cephalgia. Subsequently, in a period varying from 105 to 380 days, three patients, two of whom had twice undergone epidural blood patch, were readmitted for either surgical operation or delivery. Either epidural, caudal, or spinal block was successfully accomplished. During the epidural block, the epidural space was easily identified and no resistance was felt either to injection of the local anesthetic or to advancement of the epidural catheter. During the spinal block, ligamentum flavum was distinctly felt from the dura. The extent of the blocks, the onset and duration of action of bupivacaine, mepivacaine, and lidocaine were within normal limits. It is, therefore, concluded that epidural blood patch does not obliterate the epidural space and.should not precTirde the use of regional block for later surgical or obstetric procedures.
The Structure of Housing Finance Markets and House Prices in Asia

Emerging Asia has witnessed rapid growth of private housing and market-based housing finance in the past decade; nevertheless, market development has been uneven across countries. There is evidence that, in those economies with more flexible housing finance markets, house prices are more responsive to overall changes in market conditions, particularly equity price movements.
Performance of Brazilian children on phonemic and semantic verbal fluency tasks

The most used verbal fluency paradigms are semantic and letter fluency tasks. Studies suggest that these paradigms access semantic memory and executive function and are sensitive to frontal lobe disturbances. There are few studies in Brazilian samples on these paradigms. Objective The present study investigated performance, and the effects of age, on verbal fluency tasks in Brazilian children. The results were compared with those of other studies, and the consistency of the scoring criteria data is presented. Methods A sample of 119 children (7 to 10 years old) was submitted to the three phonemic fluency (F, A, M) tasks and three semantic fluency (animals, clothes, fruits) tasks. The results of thirty subjects were scored by two independent examiners. Results A significant positive correlation was found between the scores calculated by the two independent examiners. Significant positive correlations were found between performance on the semantic fluency task and the phonemic fluency task. The effect of age was significant for both tasks, and a significant difference was found between the 7- and 9-year-old subjects and between the 7- and 10-year-old subjects. The 8-year-old group did not differ to any of the other age groups. Conclusion The pattern of results was similar to that observed in previous Brazilian and international studies.
HEp-2 cell classification and segmentation using motif texture patterns and spatial features with random forests

Human epithelial (HEp-2) cell specimens are obtained from indirect immunofluorescence (IIF) imaging for diagnosis and management of autoimmune diseases. Analysis of HEp2 cells is important and in this work we consider automatic cell segmentation and classification using spatial and texture pattern features and random forest classifiers. In this paper, we summarize our efforts in classification and segmentation tasks proposed in ICPR 2016 contest. For the cell level staining pattern classification (Task 1), we utilized texture features such as rotational invariant co-occurrence (RIC) versions of the well-known local binary pattern (LBP), median binary pattern (MBP), joint adaptive median binary pattern (JAMBP), and motif labels (ML) along with other optimized features. We report the classification results utilizing different classifiers such as the k-nearest neighbors (kNN), support vector machine (SVM), and random forest (RF). We obtained the best accuracy of 94.26% for six cell classes with RIC-LBP combined with a motif pattern co-occurrence labels (MCL). For specimen level staining pattern classification (Task 2) we utilize a combination RIC-LBP with RF classifier and obtain 80% accuracy for seven classes. For cell segmentation (Task 4), we use our optimized multiscale spatial feature bank along with RF classifier for pixel-wise labeling to achieve an F-measure of 84.26% for 1008 images.
Reply: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers

Sir, Thank you for the opportunity to reply to the correspondence concerning our recent publication in Brain , ‘Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers’ (Mencacci et al. , 2014). We read with great interest these letters and we thank the authors for their insights. Guella et al. (2014) report the screening of GCH1 in 528 Canadian cases with Parkinson’s disease and atypical parkinsonism and 290 matched controls. They identified two variants, the known pathogenic p.K224R (×2) and the novel variant p.A99D (likely pathogenic according to in silico prediction tools and interspecies conservation) in three unrelated cases with Parkinsons’s disease and the two benign variants p.P23L and p.P69L in one single control individual. The mutational frequency, excluding the aforementioned benign variants, was 0.56% (3/528) in cases versus 0% (0/290) in controls, consistent with the frequency we observed in our study (0.75% in cases versus 0.1% in controls). This result is relevant as it represents the first independent confirmation that rare deleterious GCH1 variants are enriched in patients with Parkinson’s disease compared to control subjects. Furthermore, they describe the post-mortem findings of one of the mutated patients, who presented at the age of 82 with DOPA-responsive asymmetric rest tremor. This showed a combination of brainstem Lewy body pathology together with the presence of tau-immunoreactive neurofibrillary tangles. To date, the only available brain pathology analysis of a GCH1 -associated neurodegenerative parkinsonism case showed severe nigral neurodegeneration and Lewy bodies in surviving nigral cells and in the locus coeruleus (Gibb et al. , 1991; Segawa et al. , 2004). Further studies are needed to establish if the tauopathy described by Guella et al. …
Learning and occupational sorting

This paper develops and estimates a model of occupational choice and learning that allows for correlated learning across occupation specificabilities. In the labor market, workers learn about their potential outcomes in all occupations, not just their current occupation. Based on what they learn, workers engage in directed search across occupations. The estimates indicate that sorting occurs in multiple dimensions. Workers discovering a low ability in their current occupation are significantly more likely to move to a new occupation. At the same time, workers discovering a high ability in some occupations are more likely to move up the occupational ladder into managerial occupations. By age 28 this sorting process leads to an aggregate increase in wages similar to what would occur if all workers were endowed with an additional year of education.
Hepatoprotective Activity of Methanolic Extract of Bauhinia purpurea Leaves against Paracetamol-Induced Hepatic Damage in Rats

In an attempt to further establish the pharmacological properties of Bauhinia purpurea (Fabaceae), hepatoprotective potential of methanol extract of B. purpurea leaves (MEBP) was investigated using the paracetamol- (PCM-) induced liver toxicity in rats. Five groups of rats (n = 6) were used and administered orally once daily with 10% DMSO (negative control), 200 mg/kg silymarin (positive control), or MEBP (50, 250, and 500 mg/kg) for 7 days, followed by the hepatotoxicity induction using paracetamol (PCM). The blood samples and livers were collected and subjected to biochemical and microscopical analysis. The extract was also subjected to antioxidant study using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay with the total phenolic content (TPC) also determined. From the histological observation, lymphocyte infiltration and marked necrosis were observed in PCM-treated groups (negative control), whereas maintenance of the normal hepatic structural was observed in group pretreated with silymarin and MEBP. Hepatotoxic rats pretreated with silymarin or MEBP exhibited significant decrease (P < 0.05) in ALT and AST enzyme level. Moreover, the extract also exhibited antioxidant activity and contained high TPC. In conclusion, MEBP exerts potential hepatoprotective activity that could be partly attributed to its antioxidant activity and high phenolic content and thus warrants further investigation.
Childhood malaria in East London

Objectives. To describe the epidemiologic, clinical and laboratory features of children younger than 16 years with malaria in East London. Methods. Retrospective case review of all children admitted to two East London hospitals with malaria identified between 1996 and 2001 with the use of notifications and hospital discharge data. Results. A total of 211 children with a median age of 9 years (range, 11 to 179 months) were identified. Children living in the UK who acquired malaria while visiting a malaria-endemic country on holiday accounted for 82% of cases, whereas the rest were children visiting the UK from endemic areas. Three-fourths of children who had traveled to a malaria-endemic area were born in the UK, and 93% were of Black African ethnicity. The peak seasonal incidence was late summer/early autumn. Plasmodium falciparum acquired in Africa accounted for 91% of cases. Although 42% of children took antimalarial prophylaxis, only 15% of medications were taken according to recommended guidelines. Another family member, most often a sibling, was found to have concurrent malaria in 23% (49 of 211) of cases. On the basis of the WHO criteria, 15 children (7.1%) 15 months to 15 years of age had severe malaria, including convulsions (n = 4), acute renal failure (n = 3), jaundice (n = 4), severe anemia (n = 3) and >2% parasitemia (n = 6). Conclusions. The majority of children with malaria in this study were UK-born, school age, of Black African ethnicity and were visiting family in Africa, often with other family members. Most children had low level parasitemia and uncomplicated malaria, and they responded rapidly to antimalarial treatment.
Green Tea Polyphenol Causes Differential Oxidative Environments in Tumor versus Normal Epithelial Cells

Green tea polyphenols (GTPPs) are considered beneficial to human health, especially as chemopreventive agents. Recently, cytotoxic reactive oxygen species (ROS) were identified in tumor and certain normal cell cultures incubated with high concentrations of the most abundant GTPP, (–)-epigallocatechin-3-gallate (EGCG). If EGCG also provokes the production of ROS in normal epithelial cells, it may preclude the topical use of EGCG at higher doses. The current study examined the oxidative status of normal epithelial, normal salivary gland, and oral carcinoma cells treated with EGCG, using ROS measurement and catalase and superoxide dismutase activity assays. The results demonstrated that high concentrations of EGCG induced oxidative stress only in tumor cells. In contrast, EGCG reduced ROS in normal cells to background levels. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and 5-bromodeoxyuridine incorporation data were also compared between the two oral carcinoma cell lines treated by EGCG, which suggest that a difference in the levels of endogenous catalase activity may play an important role in reducing oxidative stress provoked by EGCG in tumor cells. It is concluded that pathways activated by GTPPs or EGCG in normal epithelial versus tumor cells create different oxidative environments, favoring either normal cell survival or tumor cell destruction. This finding may lead to applications of naturally occurring polyphenols to enhance the effectiveness of chemo/radiation therapy to promote cancer cell death while protecting normal cells.
What is Going On in Higher Education?: Is It Time for a Change?

In her ASHE presidential address, Judith Dozier Hackman argues that it is indeed time for a change. Taking “the view from the dean’s office,” she identifies and documents four underlying forces: increasing gender equality, globalism, multiculturalism, and technology. Because organizational change is more often possible during times of disarray, she recommends that we study and capitalize on these turbulent forces for the future.
Viral load versus CD4+ monitoring and 5-year outcomes of antiretroviral therapy in HIV-positive children in Southern Africa: a cohort-based modelling study

Objectives:Many paediatric antiretroviral therapy (ART) programmes in Southern Africa rely on CD4+ to monitor ART. We assessed the benefit of replacing CD4+ by viral load monitoring. Design:A mathematical modelling study. Methods:A simulation model of HIV progression over 5 years in children on ART, parameterized by data from seven South African cohorts. We simulated treatment programmes with 6-monthly CD4+ or 6- or 12-monthly viral load monitoring. We compared mortality, second-line ART use, immunological failure and time spent on failing ART. In further analyses, we varied the rate of virological failure, and assumed that the rate is higher with CD4+ than with viral load monitoring. Results:About 7% of children were predicted to die within 5 years, independent of the monitoring strategy. Compared with CD4+ monitoring, 12-monthly viral load monitoring reduced the 5-year risk of immunological failure from 1.6 to 1.0% and the mean time spent on failing ART from 6.6 to 3.6 months; 1% of children with CD4+ compared with 12% with viral load monitoring switched to second-line ART. Differences became larger when assuming higher rates of virological failure. When assuming higher virological failure rates with CD4+ than with viral load monitoring, up to 4.2% of children with CD4+ compared with 1.5% with viral load monitoring experienced immunological failure; the mean time spent on failing ART was 27.3 months with CD4+ monitoring and 6.0 months with viral load monitoring. Conclusion:Viral load monitoring did not affect 5-year mortality, but reduced time on failing ART, improved immunological response and increased switching to second-line ART.
Geophysical Investigations Of The Tropical Quelccaya Ice Cap, Peru

Abstract During the 1978 and 1979 field seasons, ice thicknesses on the Quelccaya ice cap were determined using a Worden geodetic gravity meter along a west–east traverse and using a mono–pulse ice radar sounder along a north–south traverse. The maximum ice thickness measured was 180 ± 10 m. Based upon the known thickness of the ice cap and the net accumulation, depth–age calculations indicate that an ice core record covering at least the past 600 years and perhaps 1 300 years could be obtained from this tropical ice cap. A topographic map of the Qori Kalis glacier (the largest outlet glacier from the Quelccaya ice cap) has been compiled at a scale of 1:6 000 from 1963 aerial photography. Terrestrial photography of the glacier was obtained in 1978 and coordinates of the edge of the glacier were determined photogrammetrically. Comparison of these two shows that over this 15 year period the glacier has thinned with the terminus retreating more than 100 m. The retreat measured for the Qori Kalis glacier is consistent with the behavior of other tropical glaciers.
Role of Macrophage Inflammatory Peptide-2 in Cerulein-Induced Acute Pancreatitis and Pancreatitis-Associated Lung Injury

Acute pancreatitis is an inflammatory process of variable severity, and leukocytes are thought to play a key role in the development of pancreatitis and pancreatitis-associated lung injury. The effects of mediators released by these inflammatory cells may induce tissue damage. The aim of our study was to evaluate the role of the chemokine, macrophage inflammatory protein-2 (MIP-2), in the pathogenesis of cerulein-induced pancreatitis and pancreatitis-associated lung injury. The severity of pancreatitis was measured by serum amylase, pancreatic edema, acinar cell necrosis, and myeloperoxidase activity. Lung injury was quantitated by evaluating lung microvascular permeability and lung myeloperoxidase activity. To determine the role of MIP-2 in the pathophysiology of the disease, anti-MIP-2 antibody was administered either 1 hour before or 2 hours after the start of cerulein administration. MIP-2 concentrations increased in serum, pancreas, and lung tissues in mice treated with cerulein. Anti-MIP-2 antibody administrated either before or after cerulein partially protected against pancreas and lung injury. These results show that MIP-2 plays a key role in the pathophysiology of acute pancreatitis and that MIP-2 blockade may improve the outcome of the disease.
Association of HLA-DR, DQ Genotype With Different β-Cell Functions at IDDM Diagnosis in Japanese Children

Japanese IDDM patients have been demonstrated to have unique and different HLA associations from white patients. To elucidate the effect of HLA-associated genetic factors on the clinical heterogeneity of IDDM in Japanese people, HLA-DRB1, DQA1, and DQB1 genotypes in 88 childhood-onset Japanese IDDM patients were examined by polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) or sequence-specific primers (SSP). Of the 88 IDDM patients, 26 (29.5%) had DRB1*0405-DQA1*0302-DQB1*0401/X (DR4-DQ4/X), 38 (43.2%) had DRB1*0901-DQA1*0302-DQB1*0303/X (DR9-DQ9/X), and 9 (10.2%) were DR4/9-DQ4/9 heterozygous in the present study (X does not contain protective alleles). Clinical heterogeneity such as age distribution at onset, prevalence and serum level of anti-GAD antibodies (GADAb), and residual pancreatic β-cell function after diagnosis were compared between patients with HLA-DR4-DQ4 and DR9-DQ9. The frequency of DR9-DQ9 genotype was significantly higher in the younger (0–10 years) than in the older (11–16 years) age-group of onset, but the frequency of DR4-DQ4 was higher in the older (11–16 years) age-group. Although no association of DR-DQ genotypes with the prevalence and serum level of GADAb was found among newly diagnosed patients, long-standing DR9-DQ9 patients had significantly higher levels of GADAb than those with DR4-DQ4. While no difference in time course of serum C-peptide (CPR) levels was detected between GADAb+ and GADAb− patients, a remarkable difference was demonstrated between DR9-DQ9 and DR4-DQ4 patients. The residual pancreatic β-cell function was retained more in patients with DR4-DQ4 than in those with DR9-DQ9 at diagnosis through 12–18 months after diagnosis. These results suggest that the DR9-DQ9 genotype may induce stronger autoimmune destructive response (T-helper 1 function) against target β-cells than the DR4-DQ4 genotype does. Our findings may warrant further studies on the association of diabetogenic autoimmune response with HLA class II molecules and contribute to a clarification of interracial differences in HLA-encoded susceptibility to IDDM.