Miracle-dz/UniFAR-FTUs huggingface dataset:
Drive: Theory and Construct Validation

This article explicates the theory of drive and describes the development and validation of two measures. A representative set of drive facets was derived from an extensive corpus of human attributes (Study 1). Operationalised using an International Personality Item Pool version (the Drive:IPIP), a three-factor model was extracted from the facets in two samples and confirmed on a third sample (Study 2). The multi-item IPIP measure showed congruence with a short form, based on single-item ratings of the facets, and both demonstrated cross-informant reliability. Evidence also supported the measures’ convergent, discriminant, concurrent, and incremental validity (Study 3). Based on very promising findings, the authors hope to initiate a stream of research in what is argued to be a rather neglected niche of individual differences and non-cognitive assessment.
Heart rate, oxygen uptake, and energy cost of ascending and descending the stairs.

PURPOSE This study describes the heart rate and oxygen uptake responses during, and the intensity and caloric cost of, ascending and descending a public-access staircase. METHODS Subjects were initially assessed for their maximum oxygen uptake and heart rate on a treadmill in the laboratory. For field measurements, subjects ascended (N = 103) and descended (N = 49) 11 stories of 180 steps, each step of 15 cm in height, for a total vertical displacement of 27.0 m. RESULTS The mean oxygen uptake and heart rate during the last 30 s of ascending were 33.5 +/- 4.8 mL.kg(-1). min(-1) and 159 +/- 15 beats.min(-1), respectively. During the descent, oxygen uptake and heart rate during the last 30 s of the climb were 17.0 +/- 3.8 mL.kg(-1). min(-1) and 107 +/- 18 beats.min(-1), respectively. The estimated gross energy expended during ascending and descending were 19.7 and 9.0 kcal, or equivalent to an intensity of 9.6 and 4.9 metabolic equivalents (METs), respectively (or 10.2 and 5.2 kcal.min(-1), respectively). The caloric cost of stepping up and down a step was calculated to be 0.11 and 0.05 kcal, respectively. CONCLUSION Stair-climbing exercise using a local public-access staircase met the minimum requirements for cardiorespiratory benefits and can therefore be considered a viable exercise for most people and suitable for promotion of physical activity.
Bayesian nonparametric latent feature models

We describe a flexible nonparametric approach to latent variable modelling in which the number of latent variables is unbounded. This approach is based on a probability distribution over equivalence classes of binary matrices with a finite number of rows, corresponding to the data points, and an unbounded number of columns, corresponding to the latent variables. Each data point can be associated with a subset of the possible latent variables, which we refer to as the latent features of that data point. The binary variables in the matrix indicate which latent feature is possessed by which data point, and there is a potentially infinite array of features. We derive the distribution over unbounded binary matrices by taking the limit of a distribution over N × K binary matrices as K → ∞. We define a simple generative processes for this distribution which we call the Indian buffet process (IBP; Griffiths and Ghahramani, 2005, 2006) by analogy to the Chinese restaurant process (Aldous, 1985; Pitman, 2002). The IBP has a single hyperparameter which controls both the number of feature per object and the total number of features. We describe a two-parameter generalization of the IBP which has additional flexibility, independently controlling the number of features per object and the total number of features in the matrix. The use of this distribution as a prior in an infinite latent feature model is illustrated, and Markov chain Monte Carlo algorithms for inference are described.
Higher hemoglobin is associated with improved outcome after subarachnoid hemorrhage*

Objective:There are few data regarding anemia and transfusion after subarachnoid hemorrhage (SAH). We addressed the hypothesis that higher hemoglobin (HGB) levels are associated with less death and disability after SAH. Design:Prospective registry with automated data retrieval. Patients:Six hundred eleven patients enrolled in the Columbia University SAH Outcomes Project between August 1996 and June 2002. Setting:Neurologic intensive care unit. Interventions:Patients were treated according to standard management protocols. Measurements and Main Results:We electronically retrieved all HGB readings during the acute hospital stay for 611 consecutively admitted SAH patients. Outcomes were measured with the modified Rankin Scale at 14 days or discharge, and at 3 months. Patients who were independent (modified Rankin Scale, 0–3) at discharge or 14 days had higher mean (11.7 ± 1.5 vs. 10.9 ± 1.2, p < .001) and nadir (9.9 ± 2.1 vs. 8.6 ± 1.8, p < .001) HGB, and had higher HGB values every day in the hospital. There were similar results when patients were stratified by mortality. Higher HGB was associated with reduced risk of poor outcome (modified Rankin Scale, 4–6) at 14 days/discharge and 3 months after correcting for Hunt and Hess grade, age, history of diabetes, and cerebral infarction. Length of stay and HGB interacted such that lower HGB has a more pronounced effect with length of stay > 14 days. Conclusions:Higher HGB values are associated with improved outcomes after SAH at 14 days/discharge and 3 months. In contrast to general critical care patients, SAH patients may benefit from higher HGB. Determination of the optimal goal HGB after SAH will require separate prospective research.
Common and Specific Properties of Herpesvirus UL34/UL31 Protein Family Members Revealed by Protein ComplementationAssay

ABSTRACT The proteins encoded by the UL34 and UL31 genes of herpes simplex virus are conserved among herpesviruses. They form a complex that is essential for the egress of the herpesvirus nucleocapsids from the nucleus. In previous work on the homologous protein complex in murine cytomegalovirus (MCMV), we defined their mutual binding domains. Here, we started to map binding domains within the UL34/UL31 proteins of alpha-, beta-, and gammaherpesviruses and to locate other functional properties. A protein complementation assay (PCA) using the TEM-1 β-lactamase fragments fused to UL31 and UL34 protein homologues was used to study protein-protein interactions in cells. Wild-type MCMV M50 and M53 provided a strong reaction in the PCA, whereas mutants unable to form a complex did not. The homologous pairs of herpes simplex virus type 1, pseudorabies virus, human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), and murine herpes virus 68 proteins also reacted, with the exception of the EBV proteins. Cross-complementation was found to be positive only within the same herpesvirus subfamily. Moreover, the HCMV homologues rescued replication-defective MCMV genomes lacking one or the other gene. We identified the binding site of M53 for M50 in the first conserved region (CR1) (M. Loetzerich, Z. Ruzsics, and U. H. Koszinowski, J. Virol. 80:73-84). Here we show that the CR1 of all tested UL31 proteins contains the UL34 binding site, and chimeric proteins carrying the subfamily-specific CR1 rescued the ability to cross-complement in the PCA.
Optimality, fairness, and robustness in speed scaling designs

This work examines fundamental tradeoffs incurred by a speed scaler seeking to minimize the sum of expected response time and energy use per job. We prove that a popular speed scaler is 2-competitive for this objective and no "natural" speed scaler can do better. Additionally, we prove that energy-proportional speed scaling works well for both Shortest Remaining Processing Time (SRPT) and Processor Sharing (PS) and we show that under both SRPT and PS, gated-static speed scaling is nearly optimal when the mean workload is known, but that dynamic speed scaling provides robustness against uncertain workloads. Finally, we prove that speed scaling magnifies unfairness under SRPT but that PS remains fair under speed scaling. These results show that these speed scalers can achieve any two, but only two, of optimality, fairness, and robustness.
Compositional Learning of Relation Paths Embedding for Knowledge Base Completion

Nowadays, large-scale knowledge bases containing billions of facts have reached impressive sizes; however, they are still far from completion. In addition, most existing methods only consider the direct links between entities, ignoring the vital impact about the semantic of relation paths. In this paper, we study the problem of how to better embed entities and relations into different low dimensional spaces. A compositional learning model of relation paths embedding ( RPE) is proposed to take full advantage of additional semantic information expressed by relation paths. More specifically, using corresponding projection matrices, RPE can simultaneously embed entities into corresponding relation and path spaces. It is also suggested that type constraints could be extended from traditional relation-specific to the new proposed path-specific ones. Both of the two type constraints can be seamlessly incorporated into RPE and decrease the errors in prediction. Experiments are conducted on the benchmark datasets and the proposed model achieves significant and consistent improvements compared with the state-of-the-art algorithms for knowledge base completion.
Determinants and Patterns of Reproductive Success in the Greater Horseshoe Bat during a Population Recovery

An individual's reproductive success will depend on traits that increase access to mates, as well as the number of mates available. In most well-studied mammals, males are the larger sex, and body size often increases success in intra-sexual contests and thus paternity. In comparison, the determinants of male success in species with reversed sexual size dimorphism (RSD) are less well understood. Greater horseshoe bats (Rhinolophus ferrumequinum) exhibit RSD and females appear to exert mate choice when they visit and copulate with males in their underground territories. Here we assessed putative determinants of reproductive success in a colony of greater horseshoe bats during a 19-year period of rapid population growth. We genotyped 1080 bats with up to 40 microsatellite loci and assigned maternity to 99.5% of pups, and paternity to 76.8% of pups. We found that in spite of RSD, paternity success correlated positively with male size, and, consistent with our previous findings, also with age. Female reproductive success, which has not previously been studied in this population, was also age-related and correlated positively with individual heterozygosity, but not with body size. Remarkable male reproductive skew was detected that initially increased steadily with population size, possibly coinciding with the saturation of suitable territories, but then levelled off suggesting an upper limit to a male's number of partners. Our results illustrate that RSD can occur alongside intense male sexual competition, that male breeding success is density-dependent, and that male and female greater horseshoe bats are subject to different selective pressures.
Modulatory role of androgenic and estrogenic neurosteroids in determining the direction of synaptic plasticity in the CA1 hippocampal region of male rats

Estrogenic and androgenic neurosteroids can rapidly modulate synaptic plasticity in the brain through interaction with membrane receptors for estrogens (ERs) and androgens (ARs). We used electrophysiological recordings in slices of young and adolescent male rats to explore the influence of sex neurosteroids on synaptic plasticity in the CA1 hippocampal region, by blocking ARs or ERs during induction of long‐term depression (LTD) and depotentiation (DP) by low‐frequency stimulation (LFS) and long‐term potentiation (LTP) by high‐frequency stimulation (HFS). We found that LTD and DP depend on ARs, while LTP on ERs in both age groups. Accordingly, the AR blocker flutamide affected induction of LTD reverting it into LTP, and prevented DP, while having no effect on HFS‐dependent LTP. Conversely, ER blockade with ICI 182,780 (ICI) markedly reduced LTP, but did not influence LTD and DP. However, the receptor blockade did not affect the maintenance of either LTD or LTP. Moreover, we found that similar to LTP and LTD induced in control condition, the LTP unveiled by flutamide during LFS and residual LTP induced by HFS under ICI depended on N‐methyl‐d aspartate receptor (NMDAR) activation. Furthermore, as the synaptic paired‐pulse facilitation (PPF) was not affected by either AR or ER blockade, we suggest that sex neurosteroids act primarily at a postsynaptic level. This study demonstrates for the first time the crucial role of estrogenic and androgenic neurosteroids in determining the sign of hippocampal synaptic plasticity in male rat and the activity‐dependent recruitment of androgenic and estrogenic pathways leading to LTD and LTP, respectively.
Negative Filterin g Rejected Negative Group Cost-sensitive Classifier +-+-+-+-Filtered Channel Filtered Channel First Detection Stage Aggregated Channel Input Image Second Detection Stage Detection

We propose a novel two-stage pedestrian detection framework that combines multiscale decorrelated filters to extract more discriminative features and a novel group costsensitive boosting algorithm. The proposed boosting algorithm is based on mixture loss to alleviate the influence of annotation errors in training data and explores varying cost for different types of misclassification. Experiments on Caltech and INRIA datasets show that the proposed framework achieves the best detection performance among all state-of-the-art non-deep learning methods. In addition, the proposed approach runs 88X faster than the best performing method from the widely-known Filtered Channel Feature framework.
Serous peritoneal psammocarcinoma with an aggressive course: a case and review of the literature.

BACKGROUND Primary serous peritoneal psammocarcinoma (PSPP) is a rare variant of serous carcinoma characterized by massive psammoma body formation and low-grade cytological features. Patients with serous psammocarcinoma have a protracted clinical course and relatively favourable prognosis, although a more aggressive course of PSPP may occur. CASE PRESENTATION A 52-year-old woman suffering from abdominal pain with ascites and serum CA-125 level substantially elevated underwent an exploratory laparoscopy which revealed bulk disease. The pathology report detected PPSP at the FIGO stage IIIC. The patient received neoadjuvant chemotherapy (3 courses of paclitaxel/pegylated liposomal doxorubicin/carboplatin). Optimal interval debulking surgery was performed as the next step, followed by three courses of adjuvant chemotherapy (paclitaxel/carboplatin). Due to the fact that the patient had residual disease, at the second-look surgery she received consolidation therapy with intraperitoneal and intravenous chemotherapy carboplatin. Eight months after the completion of treatment the patient developed disease recurrence in the peritoneum. Palliative surgery (enterostomy) was performed. Furthermore, the patient received two lines of chemotherapy consisting of cyclophosphamide/cisplatin and then gemcitabine. After twenty five months she developed brain metastases, treated with palliative radiotherapy. The patient died twenty-eight months since her primary presentation of PSPP. CONCLUSION PSPP is an infrequent variant of epithelial cancer with favourable prognosis. The disease may however, take a more aggressive course. Thus, an aggressive therapy is required to postpone the progression.
Factors Associated With Pulseless Electric Activity Versus Ventricular Fibrillation: The Oregon Sudden Unexpected Death Study

Background— Corresponding with a continuing decline in the prevalence of sudden cardiac arrest cases presenting with ventricular fibrillation (VF), there has been a significant rise in the prevalence of pulseless electrical activity (PEA). Given significantly lower survival from PEA versus VF, we comprehensively investigated PEA correlates by incorporating first-responder data with lifetime clinical history information. Methods and Results— In the Portland, Ore, metropolitan area (population ≈1 million), cases of out-of-hospital sudden cardiac arrest who underwent attempted resuscitation were identified prospectively (2002–2007). Those presenting with PEA versus VF and asystole were compared with &khgr;2 tests, ANOVA, and logistic regression. A total of 1277 cases aged ≥18 years underwent resuscitation by first responders (mean age, 65±16 years; 67% male). Presenting arrhythmia was VF in 48%, PEA in 25%, and asystole/other in the remainder. Compared with VF cases, PEA cases were older (mean age, 68 versus 63 years; P=0.0002), more likely to be female (37% versus 26%; P=0.0008), and less likely to survive to hospital discharge (6% versus 25%; P<0.0001). A history of syncope was strongly associated with PEA (odds ratio, 2.6; confidence interval, 1.3 to 5.3) after adjustment for age, gender, response time, and arrest circumstances. Black race was also independently associated with PEA (odds ratio, 2.6; confidence interval, 1.3 to 5.4). Pulmonary disease and female gender were significant factors associated with PEA (P for interaction=0.04). In a subgroup analysis of resting ECGs (n=391), there were no differences in cardiac clinical history or prevalence of cardiac conduction system disease (PEA, 31.6% versus VF, 32.2%; P=0.48). Conclusions— PEA cases had a significantly higher prevalence of syncope in their lifetime, with other correlates, including black race, that were distinct from VF cases. Potential mechanistic links between syncope and future manifestation with PEA warrant further exploration.
Battery Voltage Supervisors for Miniature IoT Systems

As battery size decreases due to system size constraints in miniature Internet-of-things systems, the internal resistance of the battery increases, resulting in a large IR drop on the battery voltage, complicating battery supervising functions. In this paper, we discuss low-power battery voltage supervisors (BVSs) that are capable of handling this increased IR drop. Battery voltage, battery internal resistance, required threshold voltages, and power-on-reset delay are discussed. As examples, two low-power BVSs fabricated in a 180 nm CMOS process are described.
Fuel values of stems and branches in white oak, yellow-poplar, and sweetgum.

Fuel values were determined for stems and branches in three hardwood species: white oak, yellow-poplar, and sweetgum. A significant difference was found between the higher heating value of the stemwood and branchwood of white oak. Otherwise, no difference in higher heating value was detected due to position in tree, position in branch, branch position in tree and wood versus bark.
CELL INTERACTIONS IN THE IMMUNE RESPONSE IN VITRO

The mechanism of interaction of T and B lymphocytes was investigated in an in vitro hapten carrier system using culture chambers with two compartments separated by a cell impermeable nucleopore membrane. Because specific cell interaction occurred efficiently across this membrane, contact of T and B lymphocytes was not essential for cooperation which must have been mediated by a subcellular component or "factor. " By using different lymphoid cell populations in the lower culture chamber and activated thymus cells in the upper chamber (with antigen present in both), it was found that the antigen-specific mediator acted indirectly on B cells, through the agency of macrophages. Macrophages which had been cultured in the presence of activated T cells and antigen acquired the capacity to specifically induce antibody responses in B cell-containing lymphoid populations. Trypsinization of these macrophages inhibited their capacity to induce immune responses, indicating that the mediator of cell cooperation is membrane bound. By using antisera to both the haptenic and carrier determinants of the antigen as blocking reagents, it was demonstrated that the whole antigen molecule was present on the surface of macrophages which had been exposed to activated T cells and antigen. Because specifically activated T cells were essential a component of the antigen-specific mediator must be derived from these cells. By using anti-immunoglobulin sera as inhibitors of the binding of the mediator to macrophages, the T cell component was indeed found to contain both κ- and µ-chains and was thus presumably a T cell-derived immunoglobulin. It was proposed that cell cooperation is mediated by complexes of T cell IgM and antigen, bound to the surface of macrophage-like cells, forming a lattice of appropriately spaced antigenic determinants. B cells become immunized by interacting with this surface. With this mechanism of cell cooperation, the actual pattern of antigen-B cell receptor interactions in immunization would be the same with both thymus-dependent and independent antigens. An essential feature of the proposed mechanism of cell cooperation is that macrophage-B cell interaction must occur at an early stage of the antibody response, a concept which is supported by many lines of evidence. Furthermore this mechanism of cell interaction can be elaborated to explain certain phenomena such as the highly immunogenic macrophage-bound antigen, antigenic competition, the distinction between immunity and tolerance in B lymphocytes, and the possible mediation of tolerance by T lymphocytes.
Back‐arc strain in subduction zones: Statistical observations versus numerical modeling

Recent statistical analysis by Lallemand et al. (2008) of subduction zone parameters revealed that the back‐arc deformation mode depends on the combination between the subducting (vsub) and upper (vup) plate velocities. No significant strain is recorded in the arc area if plate kinematics verifies vup = 0.5 vsub − 2.3 (cm/a) in the HS3 reference frame. Arc spreading (shortening) occurs if vup is greater (lower) than the preceding relationship. We test this statistical law with numerical models of subduction, by applying constant plate velocities far away from the subduction zone. The subducting lithosphere is free to deform at all depths. We quantify the force applied on the two converging plates to sustain constant surface velocities. The simulated rheology combined viscous (non‐Newtonian) and brittle behaviors, and depends on water content. The influence of subduction rate vs is first studied for a fixed upper plate. After 950 km of convergence (steady state slab pull), the transition from extensional to compressive stresses in the upper plate occurs for vs ∼ 1.4 cm/a. The effect of upper plate velocity is then tested at constant subduction rate. Upper plate retreat (advance) with respect to the trench increases extension (compression) in the arc lithosphere and increases (decreases) the subducting plate dip. Our modeling confirms the statistical kinematic relationship between vsub and vup that describes the transition from extensional to compressive stresses in the arc lithosphere, even if the modeled law is shifted toward higher rates of upper plate retreat, using our set of physical parameters (e.g., 100 km thick subducting oceanic plate) and short‐term simulations. Our results make valid the choice of the HS3 reference frame for assessing plate velocity influence on arc tectonic regime. The subduction model suggests that friction along the interplate contact and the mantle Stokes reaction could be the two main forces competing against slab pull for upper mantle subductions. Besides, our simulations show that the arc deformation mode is strongly time dependent.