Miracle-dz/UniFAR-FTUs huggingface dataset:
EFFECTS OF EMOTION REGULATION ON AGGRESSIVE BEHAVIOR IN INDIVIDUALS WITH BORDERLINE PERSONALITY DISORDER

The current study examined whether individuals with borderline personality disorder (BPD) symptomatology and difficulties in emotion regulation (DERS) would vary in their aggressive behavior following mood induction. One hundred and eightyfour males and females were randomly assigned to a neutral, sadness, or anger mood induction prior to participating in a competitive reaction-time task wherein they were free to administer or refrain from administering shocks to an ostensible opponent. Results indicated that there were no main effects of gender, BPD symptomatology, difficulties in emotion regulation, or condition on aggressive behavior. Explication of a three-way interaction among BPD, gender, and condition revealed that when experiencing negative affect (anger or sadness), females endorsing higher levels of BPD symptomatology were less physically aggressive than their low BPD symptomatology counterparts. Explication of a three-way interaction among DERS, gender, and condition indicated that the variables did not significantly predict differences in aggressive behavior. INDEX WORDS: Borderline Personality Disorder, Emotion Regulation, Aggression EFFECTS OF EMOTION REGULATION ON AGGRESSIVE BEHAVIOR IN INDIVIDUALS WITH BORDERLINE PERSONALITY DISORDER SYMPTOMATOLOGY
Expression of N471D strumpellin leads to defects in the endolysosomal system

ABSTRACT Hereditary spastic paraplegias (HSPs) are genetically diverse and clinically characterised by lower limb weakness and spasticity. The N471D and several other point mutations of human strumpellin (Str; also known as WASHC5), a member of the Wiskott–Aldrich syndrome protein and SCAR homologue (WASH) complex, have been shown to cause a form of HSP known as spastic paraplegia 8 (SPG8). To investigate the molecular functions of wild-type (WT) and N417D Str, we generated Dictyostelium Str− cells and ectopically expressed StrWT-GFP or StrN471D-GFP in Str− and WT cells. Overexpression of both proteins apparently caused a defect in cell division, as we observed a clear increase in multinucleate cells. Real-time PCR analyses revealed no transcriptional changes in WASH complex subunits in Str− cells, but western blots showed a twofold decrease in the SWIP subunit. GFP-trap experiments in conjunction with mass-spectrometric analysis revealed many previously known, as well as new, Str-interacting proteins, and also proteins that no longer bind to StrN471D. At the cellular level, Str− cells displayed defects in cell growth, phagocytosis, macropinocytosis, exocytosis and lysosomal function. Expression of StrWT-GFP in Str− cells rescued all observed defects. In contrast, expression of StrN471D-GFP could not rescue lysosome morphology and exocytosis of indigestible material. Our results underscore a key role for the WASH complex and its core subunit, Str, in the endolysosomal system, and highlight the fundamental importance of the Str N471 residue for maintaining lysosome morphology and dynamics. Our data indicate that the SPG8-causing N471D mutation leads to a partial loss of Str function in the endolysosomal system. This article has an associated First Person interview with the first author of the paper. Summary: Strumpellin, a core member of the WASH complex, plays a key role in the endolysosomal system. Deficiencies in endo-/exocytosis and lysosome morphology are caused by the N471D strumpellin mutation, which is associated with spastic paraplegia 8.
Impact of rapid organism identification via matrix-assisted laser desorption/ionization time-of-flight combined with antimicrobial stewardship team intervention in adult patients with bacteremia and candidemia.

BACKGROUND Integration of rapid diagnostic testing via matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) with antimicrobial stewardship team (AST) intervention has the potential for early organism identification, customization of antibiotic therapy, and improvement in patient outcomes. The objective of this study was to assess the impact of this combined approach on clinical and antimicrobial therapy-related outcomes in patients with bloodstream infections. METHODS A pre-post quasi-experimental study was conducted to analyze the impact of MALDI-TOF with AST intervention in patients with bloodstream infections. The AST provided evidence-based antibiotic recommendations after receiving real-time notification following blood culture Gram stain, organism identification, and antimicrobial susceptibilities. Outcomes were compared to a historic control group. RESULTS A total of 501 patients with bacteremia or candidemia were included in the final analysis: 245 patients in the intervention group and 256 patients in the preintervention group. MALDI-TOF with AST intervention decreased time to organism identification (84.0 vs 55.9 hours, P < .001), and improved time to effective antibiotic therapy (30.1 vs 20.4 hours, P = .021) and optimal antibiotic therapy (90.3 vs 47.3 hours, P < .001). Mortality (20.3% vs 14.5%), length of intensive care unit stay (14.9 vs 8.3 days) and recurrent bacteremia (5.9% vs 2.0%) were lower in the intervention group on univariate analysis, and acceptance of an AST intervention was associated with a trend toward reduced mortality on multivariable analysis (odds ratio, 0.55, P = .075). CONCLUSION MALDI-TOF with AST intervention decreased time to organism identification and time to effective and optimal antibiotic therapy.
Estimating time and space in the evolution of the Lepidoptera

Several aspects of estimating what happened when and where in the evolution of the Lepidoptera are discussed. Because of their scarcity and often poor preservation, fossils are not very helpful, but at least they demonstrate that, in the Oligocene some taxa of butterflies, perhaps at tribal level or higher, did occur in the Northern as well as in the Southern Hemisphere. The concept of a molecular clock is seen as a most needed test for vicariance explanations of disjunct distributions. Special emphasis is laid on the importance of calibration of the clock. The use of geological vicariance events as calibration points is rejected, because of circularity when vicariance explanations are to be tested. Fossils as calibration points should ideally be replaced by the minimum age of an apomorphous character state demonstrated by the fossil rather than a supposed identity on the basis of overall similarity. Some conditions that directed the evolution of Lepidoptera (called constraints here) are discussed for their possible use as calibration points. Estimation of the evolution in space through time (palaeobiogeography) as found in recent literature is discussed, the often supposed role (of the break-up) of Gondwana in the evolution of the butterflies is challenged, and an alternative hypothesis is given. R. de Jong, National Museum of Natural History, P.O. Box 9517, 2300 RA Leiden, The Netherlands. E-mail: jong@naturalis.nnm. nl
Defense Against Universal Adversarial Perturbations

Recent advances in Deep Learning show the existence of image-agnostic quasi-imperceptible perturbations that when applied to 'any' image can fool a state-of-the-art network classifier to change its prediction about the image label. These 'Universal Adversarial Perturbations' pose a serious threat to the success of Deep Learning in practice. We present the first dedicated framework to effectively defend the networks against such perturbations. Our approach learns a Perturbation Rectifying Network (PRN) as 'pre-input' layers to a targeted model, such that the targeted model needs no modification. The PRN is learned from real and synthetic image-agnostic perturbations, where an efficient method to compute the latter is also proposed. A perturbation detector is separately trained on the Discrete Cosine Transform of the input-output difference of the PRN. A query image is first passed through the PRN and verified by the detector. If a perturbation is detected, the output of the PRN is used for label prediction instead of the actual image. A rigorous evaluation shows that our framework can defend the network classifiers against unseen adversarial perturbations in the real-world scenarios with up to 97.5% success rate. The PRN also generalizes well in the sense that training for one targeted network defends another network with a comparable success rate.
Percutaneous Coronary Intervention of Left Main Disease: Pre- and Post-EXCEL (Evaluation of XIENCE Everolimus Eluting Stent Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) and NOBLE (Nordic-Baltic-British Left Main Revascularization Study) Era

For nearly half a century, coronary artery bypass grafting has been the standard treatment for patients with obstructive left main coronary artery (LMCA) disease. However, there has been considerable evolution in the field of percutaneous coronary intervention, and especially, percutaneous coronary intervention for LMCA disease has been rapidly expanded with adoption of drug-eluting stents. Some, but not all randomized trials, have shown that percutaneous coronary intervention with drug-eluting stents might be a suitable alternative for selected patients with LMCA disease instead of bypass surgery. However, none of previous trials involving early-generation drug-eluting stents was sufficiently powered and comparative trials using contemporary drug-eluting stents were limited. Recently, primary results of 2 new trials of EXCEL (Evaluation of XIENCE Everolimus Eluting Stent Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) and NOBLE (Nordic-Baltic-British Left Main Revascularization Study) were reported. However, these trials showed conflicting results, which might pose uncertainty on the optimal revascularization strategy for LMCA disease. In this article, with the incorporation of a key review on evolution of LMCA treatment, we summarize the similarity or disparity of the EXCEL and NOBLE trials, focus on how they relate to previous trials in the field, and finally speculate on how the treatment strategy may be changed or recommended for LMCA treatment.
Tunable Weyl and Dirac states in the nonsymmorphic compound CeSbTe

By establishing magnetic order in a square lattice compound, we introduce the first magnetic “new fermion. ” Recent interest in topological semimetals has led to the proposal of many new topological phases that can be realized in real materials. Next to Dirac and Weyl systems, these include more exotic phases based on manifold band degeneracies in the bulk electronic structure. The exotic states in topological semimetals are usually protected by some sort of crystal symmetry, and the introduction of magnetic order can influence these states by breaking time-reversal symmetry. We show that we can realize a rich variety of different topological semimetal states in a single material, CeSbTe. This compound can exhibit different types of magnetic order that can be accessed easily by applying a small field. Therefore, it allows for tuning the electronic structure and can drive it through a manifold of topologically distinct phases, such as the first nonsymmorphic magnetic topological phase with an eightfold band crossing at a high-symmetry point. Our experimental results are backed by a full magnetic group theory analysis and ab initio calculations. This discovery introduces a realistic and promising platform for studying the interplay of magnetism and topology. We also show that we can generally expand the numbers of space groups that allow for high-order band degeneracies by introducing antiferromagnetic order.
Role of Melatonin in Body Weight: A Systematic Review and Meta-Analysis.

BACKGROUND Some trials on animals and human claim that melatonin can influence body weight. So we conducted a systematic review of controlled trials of melatonin effects on weight of human subjects. METHODS First we performed a systematic and comprehensive search in June 2015 on MEDLINE/PubMed, Scopus, Google scholar, hand searching in key journals, the list of references of selected articles and gray literature. RESULTS We included 7 clinical trials with a total of 244 patients. All studies were parallel clinical trials conducted at the clinic. Evaluating standardized mean difference (SMD) using Cohen's method shows that none of the included studies have found a strong and significant effect of melatonin on body weight. However, some have reported decreasing or increasing effect of melatonin on body weight. We pooled SMDs using random effects (DerSimonian and Laird). Pooled SMD was still not significant SMD (95% CI) = 0.09(-0.17-0.34), with lack of heterogeneity I2=0.0%, p=0.66. CONCLUSION We concluded that once the standard treatment had increasing effect on body weight, melatonin could be able to slightly diminish this effect and vice versa. Subgroup analysis showed that melatonin was more effective in child and adolescents. According to the results hypothesis of the buffering role of melatonin on body weight fluctuations can be proposed.
The role of accent imitation in sensorimotor integration during processing of intelligible speech

Recent theories on how listeners maintain perceptual invariance despite variation in the speech signal allocate a prominent role to imitation mechanisms. Notably, these simulation accounts propose that motor mechanisms support perception of ambiguous or noisy signals. Indeed, imitation of ambiguous signals, e.g., accented speech, has been found to aid effective speech comprehension. Here, we explored the possibility that imitation in speech benefits perception by increasing activation in speech perception and production areas. Participants rated the intelligibility of sentences spoken in an unfamiliar accent of Dutch in a functional Magnetic Resonance Imaging experiment. Next, participants in one group repeated the sentences in their own accent, while a second group vocally imitated the accent. Finally, both groups rated the intelligibility of accented sentences in a post-test. The neuroimaging results showed an interaction between type of training and pre- and post-test sessions in left Inferior Frontal Gyrus, Supplementary Motor Area, and left Superior Temporal Sulcus. Although alternative explanations such as task engagement and fatigue need to be considered as well, the results suggest that imitation may aid effective speech comprehension by supporting sensorimotor integration.
Impact of maternal education, employment and family size on nutritional status of children

Objective: To determine the impact of maternal education, employment, and family size on nutritional status of children. Methods: It was case control study conducted at OPD of children Hospital Lahore, from September 2015 to April 2017. Total 340 children (170 cases and 170 controls) with age range of six months to five years along with their mothers were included. Anthropometric measurements were plotted against WHO growth Charts. 170 wasted (<-2 SD) were matched with 170 controls (≥ -2 SD). Maternal education, employment and family size were compared between the cases and control. Confounding variables noted and dichotomized. Univariate analysis was carried out for factors under consideration i.e.; Maternal Education, employment and family size to study the association of each factor. Logistic regression analysis was applied to study the independent association. Results: Maternal education had significant association with growth parameters; OR of 1.32 with confidence interval of (CI= 1.1 to 1.623). Employment status of mothers had OR of 1.132 with insignificant confidence interval of (CI=0.725 to 1.768). Family size had OR of one with insignificant confidence interval (CI=0.8 -1.21). Association remained same after applying bivariate logistic regression analysis. Conclusion: Maternal education has definite and significant effect on nutritional status of children. This is the key factor to be addressed for prevention or improvement of childhood malnutrition. For this it is imperative to launch sustainable programs at national and regional level to uplift women educational status to combat this ever increasing burden of malnutrition.
Biochemical regulation of pigment motility in vertebrate chromatophores: a review of physiological color change mechanisms

Abstract The fundamental unit of rapid, physiological color change in vertebrates is the dermal chromatophore unit. This unit, comprised of cellular associations between different chromatophore types, is relatively conserved across the fish, amphibian, and reptilian species capable of physiological color change and numerous attempts have been made to understand the nature of the four major chromatophore types (melanophores, erythrophores, xanthophores, and iridophores) and their biochemical regulation. In this review, we attempt to describe the current state of knowledge regarding what classifies a pigment cell as a dynamic chromatophore, the unique characteristics of each chromatophore type, and how different hormones, neurotransmitters, or other signals direct pigment reorganization in a variety of vertebrate taxa.
Predictors for Gingival Index in Middle-Aged Asian Indians with Type 2 Diabetes from South India: A Cross-Sectional Observational Study

Asian Indians develop type 2 diabetes mellitus (T2DM) much earlier as compared to White Caucasians, due to unique phenotypic and genetic architecture. Periodontitis in T2DM patients is often a neglected clinical feature. This study was conducted to derive predictor variables for gingival index in middle-aged Asian Indians with T2DM in a semiurban population of Dravidian ethnicity from Tamil Nadu, India. T2DM patients (n = 232, mean age: 50.6 ± 10.4 years) with periodontitis (n = 123, mean age: 54.3 ± 2.4 years) and without periodontitis (n = 109, mean age: 55.2 ± 3.1 years) were recruited between 2014 and 2016 by purposive sampling method. Dental examinations for pocket depth (PD) and clinical attachment level (CAL) were performed and gingival index was calculated. Fasting venous blood samples were analysed for measures of glycaemia and cholesterol. Significant positive correlation (p < 0.01) was observed for gingival index with glycosylated haemoglobin (HbA1c), pocket depth, presence of T2DM, and clinical attachment level. Stepwise multiple linear regression analysis derived increased pocket depth (p < 0.01), elevated HbA1c (p < 0.01), clinical attachment level (p < 0.01), and presence of diabetes (p < 0.01) as significant predictors (r 2 value = 0.67) for increased gingival index in middle aged patients with T2DM. These variables significantly (p < 0.01) predispose middle-aged T2DM patients to increased gingival index, thus warranting appropriate intervention.
Substrate Shift Reveals Roles for Members of Bacterial Consortia in Degradation of Plant Cell Wall Polymers

Deconstructing the intricate matrix of cellulose, hemicellulose, and lignin poses a major challenge in biofuel production. In diverse environments in nature, some microbial communities, are able to overcome plant biomass recalcitrance. Identifying key degraders of each component of plant cell wall can help improve biological degradation of plant feedstock. Here, we sequenced the metagenome of lignocellulose-adapted microbial consortia sub-cultured on xylan and alkali lignin media. We observed a drastic shift on community composition after sub-culturing, independently of the original consortia. Proteobacteria relative abundance increased after growth in alkali lignin medium, while Bacteroidetes abundance increased after growth in xylan medium. At the genus level, Pseudomonas was more abundant in the communities growing on alkali lignin, Sphingobacterium in the communities growing on xylan and Cellulomonas abundance was the highest in the original microbial consortia. We also observed functional convergence of microbial communities after incubation in alkali lignin, due to an enrichment of genes involved in benzoate degradation and catechol ortho-cleavage pathways. Our results represent an important step toward the elucidation of key members of microbial communities on lignocellulose degradation and may aide the design of novel lignocellulolytic microbial consortia that are able to efficiently degrade plant cell wall polymers.
Cosmic web and environmental dependence of screening: Vainshtein vs. chameleon

Theories which modify general relativity to explain the accelerated expansion of the Universe often use screening mechanisms to satisfy constraints on Solar System scales. We investigate the effects of the cosmic web and the local environmental density of dark matter halos on the screening properties of the Vainshtein and chameleon screening mechanisms. We compare the cosmic web morphology of dark matter particles, mass functions of dark matter halos, mass and radial dependence of screening, velocity dispersions and peculiar velocities, and environmental dependence of screening mechanisms in f(R) and nDGP models. Using the ORIGAMI cosmic web identification routine we find that the Vainshtein mechanism depends on the cosmic web morphology of dark matter particles, since these are defined according to the dimensionality of their collapse, while the chameleon mechanism shows no morphology dependence. The chameleon screening of halos and their velocity dispersions depend on halo mass, and small halos and subhalos can be environmentally screened in the chameleon mechanism. On the other hand, the screening of halos in the Vainshtein mechanism does not depend on mass nor environment, and their velocity dispersions are suppressed. The peculiar velocities of halos in the Vainshtein mechanism are enhanced because screened objects can still feel the fifth force generated by external fields, while peculiar velocities of chameleon halos are suppressed when the halo centers are screened.
Coupling Basin‐ and Site‐Scale Inverse Models of the Espanola Aquifer

Large‐scale models are frequently used to estimate fluxes to small‐scale models. The uncertainty associated with these flux estimates, however, is rarely addressed. We present a case study from the Española Basin, northern New Mexico, where we use a basin‐scale model coupled with a high‐resolution, nested site‐scale model. Both models are three‐dimensional and are analyzed by codes FEHM and PEST. Using constrained nonlinear optimization, we examine the effect of parameter uncertainty in the basin‐scale model on the nonlinear confidence limits of predicted fluxes to the site‐scale model. We find that some of the fluxes are very well constrained, while for others there is fairly large uncertainty. Site‐scale transport simulation results, however, are relatively insensitive to the estimated uncertainty in the fluxes. We also compare parameter estimates obtained by the basin‐ and site‐scale inverse models. Differences in the model grid resolution (scale of parameter estimation) result in differing delineation of hydrostratigraphic units, so the two models produce different estimates for some units. The effect is similar to the observed scale effect in medium properties owing to differences in tested volume. More important, estimation uncertainty of model parameters is quite different at the two scales. Overall, the basin inverse model resulted in significantly lower estimates of uncertainty, because of the larger calibration dataset available. This suggests that the basin‐scale model contributes not only important boundary condition information but also improved parameter identification for some units. Our results demonstrate that caution is warranted when applying parameter estimates inferred from a large‐scale model to small‐scale simulations, and vice versa.