Miracle-dz/UniFAR-FTUs huggingface dataset:
An experimental study of passive dynamic walking

A two-straight-legged walking mechanism with flat feet is designed and built to study the passive dynamic gait. It is shown that the mechanism having flat feet can exhibit passive dynamic walking as those with curved feet, but the walking efficiency is significantly lower. It is also shown that the balancing mass and its orientation are effective for controlling side-to-side rocking and yaw, which have significant effects on steady walking. The effects of various parameters on the gait patterns are also studied. lt is shown that changes in the ramp angle have the most dominant effect on the gait pattern as compared with the changes in the hip mass, ramp surface friction and size of the flat feet. More specifically, as the ramp angle increases, the step length increases while the range of the side-to side rocking angle decreases and the step length dictates the walking speed and the gravitational power. Another finding, is that adding a hip mass improves the walking efficiency by allowing the mechanism to walk on a flatter ramp. This research enables us to gain a better understanding of the mechanics of walking. Such an understanding will have a direct impact on better design of prostheses and on the active control aspects of bipedal robots.
A New Treatment Strategy for Parkinson's Disease through the Gut–Brain Axis

Molecular communications in the gut–brain axis, between the central nervous system and the gastrointestinal tract, are critical for maintaining healthy brain function, particularly in aging. Epidemiological analyses indicate type 2 diabetes mellitus (T2DM) is a risk factor for neurodegenerative disorders including Alzheimer's disease (AD) and Parkinson's diseases (PD) for which aging shows a major correlative association. Common pathophysiological features exist between T2DM, AD, and PD, including oxidative stress, inflammation, insulin resistance, abnormal protein processing, and cognitive decline, and suggest that effective drugs for T2DM that positively impact the gut–brain axis could provide an effective treatment option for neurodegenerative diseases. Glucagon-like peptide-1 (GLP-1)-based antidiabetic drugs have drawn particular attention as an effectual new strategy to not only regulate blood glucose but also decrease body weight by reducing appetite, which implies that GLP-1 could affect the gut–brain axis in normal and pathological conditions. The neurotrophic and neuroprotective effects of GLP-1 receptor (R) stimulation have been characterized in numerous in vitro and in vivo preclinical studies using GLP-1R agonists and dipeptidyl peptidase-4 inhibitors. Recently, the first open label clinical study of exenatide, a long-acting GLP-1 agonist, in the treatment of PD showed long-lasting improvements in motor and cognitive function. Several double-blind clinical trials of GLP-1R agonists including exenatide in PD and other neurodegenerative diseases are already underway or are about to be initiated. Herein, we review the physiological role of the GLP-1R pathway in the gut–brain axis and the therapeutic strategy of GLP-1R stimulation for the treatment of neurodegenerative diseases focused on PD, for which age is the major risk factor.
Bilaterality in anterior cruciate ligament injuries

Nonsimultaneous, bilateral ACL injuries are not uncom mon. We studied a group of patients with these injuries to determine possible predisposing factors that could aid in early detection and prevention of contralateral ACL injury. Retrospective analysis of 1,120 patients with ACL ruptures who were treated between 1983 and 1987 revealed 45 patients with bilateral ruptures. Complete follow-up data were available for 41 of these patients. We examined age at initial injury, sex, interval between initial and contralateral ACL injury, mechanism of injury, activity at injury, medical and family histories, treatment of initial injury, and radiographic measurement of inter condylar notch width. The overall incidence of bilaterality was 4.01 % in the 28 male and 13 female patients. Their average age was 19 years and 10 months. The average interval between initial and contralateral injury was 47 months. A non contact cutting maneuver was the most common mech anism of injury. We devised a method to measure and compare in tercondylar notch widths on plain radiographs. We com pared the mean notch width index (NWI) of the bilateral group to the mean NWI of a group of 50 consecutive patients with "normal" knees and to the mean NWI of 50 consecutive patients with acute ACL ruptures. The mean NWI for the normal group was . 2338, for the acute ACL group, . 2248, and for the bilateral group, . 1961. We noted a statistically significant difference when we compared the bilateral group to the normal and acute groups (P < 0.0001, respectively). There was no statistically significant difference between the NWI of the normal and acute ACL groups. None of the other variables studied were found to be significant. We identified a large subgroup of patients (59%) in the bilateral group who had sustained their initial injury at a relatively young age (average, 16 years) through noncontact mechanisms and who had a low NWI. These patients sustained their contralateral injury within 2 years of their initial ACL injury (average interval, 15 months) regardless of their initial treatment. We believe that young individuals who sustain an ACL tear by noncontact mechanisms and have a low NWI, carry a significant risk for contralateral ACL rup ture and should be strongly counseled regarding that possibility.
Best Practices or Best Guesses? Assessing the Efficacy of Corporate Affirmative Action and Diversity Policies

Employers have experimented with three broad approaches to promoting diversity. Some programs are designed to establish organizational responsibility for diversity, others to moderate managerial bias through training and feedback, and still others to reduce the social isolation of women and minority workers. These approaches find support in academic theories of how organizations achieve goals, how stereotyping shapes hiring and promotion, and how networks influence careers. This is the first systematic analysis of their efficacy. The analyses rely on federal data describing the workforces of 708 private sector establishments from 1971 to 2002, coupled with survey data on their employment practices. Efforts to moderate managerial bias through diversity training and diversity evaluations are least effective at increasing the share of white women, black women, and black men in management. Efforts to attack social isolation through mentoring and networking show modest effects. Efforts to establish responsibility for diversity lead to the broadest increases in managerial diversity. Moreover, organizations that establish responsibility see better effects from diversity training and evaluations, networking, and mentoring. Employers subject to federal affirmative action edicts, who typically assign responsibility for compliance to a manager, also see stronger effects from some programs. This work lays the foundation for an institutional theory of the remediation of workplace inequality.
1H-NMR Spectroscopy of Cerebrospinal Fluid of Fetal Sheep during Hypoxia-Induced Acidemia and Recovery

The purpose of the study was to investigate the sequence of processes occurring during and after hypoxia-induced acidemia. We used proton nuclear magnetic resonance spectroscopy, which provides an overview of metabolites in cerebrospinal fluid (CSF), reflecting neuronal metabolism and damage. The pathophysiological condition of acute fetal asphyxia was mimicked by reducing maternal uterine blood flow in 14 unanesthetized pregnant ewes. CSF metabolites were measured during hypoxia-induced acidemia, and during the following recovery period, including the periods at 24 and 48 h after the hypoxic insult. Maximum values of the following CSF metabolites were reached during severe hypoxia (pH ≤ 7.00): glucose, lactate, pyruvate, hypoxanthine, alanine, β-hydroxybutyrate, choline, creatine, myo-inositol, citrate, succinate, valine, and an unknown metabolite characterized by a resonance at 1.56 ppm in the proton nuclear magnetic resonance spectrum. Twenty-four hours after the hypoxic insult, myo-inositol was increased, and alanine was decreased 48 h after the hypoxic insult, both compared with control values. Choline levels in CSF had a linear relationship with arterial pH (r = 0.26, p < 0.005). During severe hypoxia, CSF levels of succinate and choline are increased. Increased CSF levels of succinate may indicate dysfunction of the mitochondrial respiratory chain, whereas elevated CSF choline levels may indicate disrupted cell membranes. The increase of the CSF myo-inositol level after 24 and 48 h may indicate osmolytic cell changes causing cell edema. Decreased alanine level may represent changes in the source of excitatory amino acid synthesis.
Helping Others, Warming Yourself: Altruistic Behaviors Increase Warmth Feelings of the Ambient Environment

Altruistic behaviors typically improve the welfare of the recipient at the cost of the performer’s resources and energy. Do altruistic performers obtain any positive internal reward from altruistic behaviors? We conducted six experiments to explore whether altruistic behaviors could increase performer’s warmth perception of the ambient environment. The first three studies focused on crisis situations. A retrospective field study (Study 1, with Hurricane Sandy) and two laboratory studies (Studies 2a and 2b, with an earthquake scenario) found that people who helped others felt warmer of the ambient environment than people who did not. We extended to daily life situations and found that participants who performed helping behaviors in laboratory (either voluntarily in Study 3a or randomly assigned to in Study 3b) and passers-by who donated to a charity (Study 4) reported warmer perception of the ambient environment than those who did not. These findings suggested an immediate internal reward of altruism.
A Framework for Supporting Metacognitive Aspects of Online Inquiry Through Software-Based Scaffolding

Major educational policy groups call on learners to engage in inquiry-based activities. With a growing amount of information now available online, there is an increased focus on online inquiry where learners ask research questions; search digital libraries and other information sources; and read, assess, and synthesize that information. Metacognitive skills are important for engaging in complex practices like online inquiry, but those skills are weak in novice learners. In this article, we propose a framework that describes the types of metacognitive problems that learners exhibit during online inquiry and the ways that software can serve a scaffolding function to address those problems and support learners through those metacognitive issues. Specifically, we consider how three categories of metacognition relate to online inquiry—task understanding and planning, monitoring and regulation, and reflection—and the issues learners face within each. Our framework describes different types of scaffolding features from a range of software tools that can support learners with the identified metacognitive issues in different ways, such as by describing online inquiry task structures for better task understanding, making planning an explicit activity, helping learners see online inquiry task spaces and strategies to monitor and regulate work, and describing to learners the important aspects of online inquiry that they should reflect on during their work. A common thread with these scaffolding features is the fact that they make different aspects of metacognition, which tends to be implicit to learners, more explicit so learners can engage in the metacognitive activity that they otherwise tend to bypass.
Great tits Parus major trade health for reproduction

Reproduction and maintenance compete for resources within a single individual. But do individuals invest in reproduction just as much as remains after the requirements of maintenance are covered, or do they sacrifice their health for the sake of still further increase the investment in current reproduction? This question has been found hard to answer because of difficulties of demonstrating that individuals naturally make a reproductive effort of such a magnitude as to inflict health damage. In this paper we present evidence for a trade-off between reproductive effort and health state in great tits, indicated by a positive correlation between total prefledging brood weight and both intensity of Haemoproteus blood parasite infection and heterophile: lymphocyte (H:L) ratio. H:L ratios, which signal stress in birds, were high both among individuals making an intense reproductive effort and among aberrantly behaving individuals, such as females incubating in empty nests and birds which abandoned their broods after blood sampling. Experimental reduction of clutch size resulted in decreased intensity of Haemoproteus parasitemia, providing further evidence that individual great tits accept immunosuppression to increase their reproductive investment.
Improved treatment for anovulation in polycystic ovarian disease utilizing the effect of progesterone on the inappropriate gonadotrophin release and clomiphene response.

The treatment of anovulatory, clomiphene-resistant patients with polycystic ovarian disease (PCOD) is difficult. Ten such women were given progesterone, 50 mg/day i.m. for 5 days to achieve luteal phase concentrations. Immediately following progesterone treatment, plasma concentrations of FSH were reduced in all patients (P = 0.001) and seven of the 10 had reduced plasma LH concentrations. Following the withdrawal bleeding these seven all became responsive to clomiphene as shown by ovulation, and three conceived after a single progesterone/clomiphene cycle. LH pulsatility, studied in five women over 4 h, before and immediately following progesterone treatment, showed a slowing of the pulse frequency (62 +/- 26 min to 105 +/- 51 min, P less than 0.05) and an increase in pulse amplitude (6 +/- 1.9 IU/l to 16.7 +/- 20 IU/l). The LH and FSH response to GnRH was blunted by progesterone. It would thus appear that progesterone modulates LH pulsatility and reduces pituitary sensitivity to GnRH, reducing LH levels and possibly inducing more FSH synthesis and storage, similar to its action in the normal ovulatory cycle. These changes provide a more favourable environment for ovulation induction by clomiphene and we suggest that short-term progesterone treatment may be utilized to improve the efficiency and results of clomiphene treatment in PCOD.
Intergenerational Wellness Programming in Occupational Therapy

Abstract An intergenerational Wellness program was implemented by occupational therapy students at Laboure House located in Chicago, Illinois, in the fall of 2001 as part of a grant funded by the National Service Corporation in conjunction with the Association for Gerontology in Higher Education. Program goals include: (a) developing students' skills in evaluation and Wellness programming by participating in an intergenerational service learning project, (b) providing occupation-based Wellness programming for the residents, and (c) promoting Wellness for the residents by encouraging them to find meaning in their lives through a variety of wellness/health promotion activities. Outcome measures used to assess change in the residents included the COPM (Canadian Occupational Performance Measure) (Law, Baptiste, Carswell, McColl, Polatajko, & Pollock, 1998) and the SF-36 (Ware, 1992). Tools used to assess students' performance included internship assessment forms and qualitative data from students' reflective journals. Preliminary results indicate improvement in awareness of Wellness and health promotion activities by the residents as well as a positive learning experience for students.
Commemoration of the Great War on the Somme: exploring personal connections

This study was undertaken at two sites on the Somme, France, one of the main battlefields of the Great War (1914–1918). It used a quantitative method and sought to explore the relative strength of two bases of personal connection (family and nation) to interests in visiting the area. The impact of attendance at a commemorative event on visitors' battlefield interests was also explored. The sample at the Thiepval memorial was dominated by British visitors and by Australians at Villers-Bretonneux. The analysis indicated that people with close family connections to the war had higher levels of interest in seeing sites of their family's war-time involvement, desire to pay their respects and historical interest. Attendance at a major national event (Anzac Day) appeared to increase national interest in people who did not have family connections.
A Conceptual Framework for Describing Online Entrepreneurship

Abstract Most of the literature on entrepreneurship relates to the traditional “brick-and-mortar” type. A review of contemporary research in entrepreneurship literature suggests that online entrepreneurs are different from regular, or “brick-and-mortar” entrepreneurs. This paper attempts to collate all variables used in prior research to describe entrepreneurs and their ventures into a comprehensive framework. This framework considers four major aspects of entrepreneurship: characteristics of individuals starting the venture; technology used in the venture; the environment in which the venture operates and the process by which the venture is created. Such a framework can provide useful insights into the process of online entrepreneurship by showing it to be a complex, multi-factor phenomenon.
Differential Effects of Visual-Acoustic Biofeedback Intervention for Residual Speech Errors

Recent evidence suggests that the incorporation of visual biofeedback technologies may enhance response to treatment in individuals with residual speech errors. However, there is a need for controlled research systematically comparing biofeedback versus non-biofeedback intervention approaches. This study implemented a single-subject experimental design with a crossover component to investigate the relative efficacy of visual-acoustic biofeedback and traditional articulatory treatment for residual rhotic errors. Eleven child/adolescent participants received ten sessions of visual-acoustic biofeedback and 10 sessions of traditional treatment, with the order of biofeedback and traditional phases counterbalanced across participants. Probe measures eliciting untreated rhotic words were administered in at least three sessions prior to the start of treatment (baseline), between the two treatment phases (midpoint), and after treatment ended (maintenance), as well as before and after each treatment session. Perceptual accuracy of rhotic production was assessed by outside listeners in a blinded, randomized fashion. Results were analyzed using a combination of visual inspection of treatment trajectories, individual effect sizes, and logistic mixed-effects regression. Effect sizes and visual inspection revealed that participants could be divided into categories of strong responders (n = 4), mixed/moderate responders (n = 3), and non-responders (n = 4). Individual results did not reveal a reliable pattern of stronger performance in biofeedback versus traditional blocks, or vice versa. Moreover, biofeedback versus traditional treatment was not a significant predictor of accuracy in the logistic mixed-effects model examining all within-treatment word probes. However, the interaction between treatment condition and treatment order was significant: biofeedback was more effective than traditional treatment in the first phase of treatment, and traditional treatment was more effective than biofeedback in the second phase. This is consistent with existing theory and data suggesting that detailed knowledge of performance feedback is most effective in the early stages of motor learning. Further research is needed to confirm that an initial phase of biofeedback has a facilitative effect, and to determine the optimal duration of biofeedback treatment. In addition, there is a strong need for correlational studies to examine which individuals with residual speech errors are most likely to respond to treatment.
The response of human ectomesenchymal dental pulp stem cells to cisplatin treatment.

AIM To determine the response of dental pulp stem cells (DPSCs) to DNA-damaging cytostatic cisplatin and compare it with the response of normal human dermal fibroblasts (HDFs). METHODOLOGY Dental pulp stem cells were exposed to 5, 10, 20 or 40 μmol L(-1) of cisplatin. The proliferation of affected cells was assessed by a Z2 Counter and viability was assessed by means of a Vi-Cell XR using Trypan blue exclusion staining. Cell cycle analysis and induction of apoptosis were performed by flow cytometry. Induction of apoptosis was determined by monitoring the activities of caspases. The expression of proteins was detected by electrophoresis and Western blotting. The descriptive statistics of the results was analyzed by Student's t-test. RESULTS Dental pulp stem cells had a greater genotoxic stress response to cisplatin compared to HDFs. All three main Mitogen-activated protein kinases (MAPK) families - extracellular signal-regulated kinases (ERK), c-Jun-N-terminal kinase (JNK) and p38 were activated after treatment of DPSCs with cisplatin. The activation of MAPK pathways was not observed in HDFs exposed to cisplatin. The exposure of DPSCs and HDFs to cisplatin provoked an increase in p53 and p21 expression and p53 phosphorylation of serine 15. Higher concentrations of cisplatin reduced the viability of DPSCs and HDFs and induced the activation of caspases 3/7 and 9. CONCLUSION Dental pulp stem cells had a greater genotoxic stress response to cisplatin compared to HDFs. Cisplatin in higher concentrations triggered activation of MAPK and apoptosis in DPSCs but not in HDFs.
A single-inductor dual-output switching converter with low ripples and improved cross regulation

This paper proposes a novel fly capacitor method for single-inductor dual-output (SIDO) switching converters to reduce the output ripples and spikes. An adaptive common-mode control is presented to suppress the cross regulation problem. The converter can automatically switch between pulse-width modulation (PWM) and pulse-frequency modulation (PFM) control to improve the efficiency. The SIDO converter is specified for one channel 1.2 V/400 mA and the other 1.8 V/200 mA with input voltage ranging from 2.7 V to 5 V. The chip has been fabricated on a 0.25 μm CMOS mixed signal process. The conversion efficiency is 82% at a total output power of 840 mW while the output ripples are about 20 mV and spikes less than 40 mV.
Children’s Arithmetic Development

In this article, we present the results of an 11-month longitudinal study (beginning when children were 6 years old) focusing on measures of the approximate number sense (ANS) and knowledge of the Arabic numeral system as possible influences on the development of arithmetic skills. Multiple measures of symbolic and nonsymbolic magnitude judgment were shown to define a unitary factor that appears to index the efficiency of an ANS system, which is a strong longitudinal correlate of arithmetic skills. However, path models revealed that knowledge of Arabic numerals at 6 years was a powerful longitudinal predictor of the growth in arithmetic skills, whereas variations in magnitude-comparison ability played no additional role in predicting variations in arithmetic skills. These results suggest that verbal processes concerned with learning the labels for Arabic numerals, and the ability to translate between Arabic numerals and verbal codes, place critical constraints on arithmetic development.