Miracle-dz/UniFAR-FTUs huggingface dataset:
Twenty Years of Responsive Regulation: An Appreciation and Appraisal

This special issue of Regulation and Governance celebrates and appraises twenty years since the publication of Ian Ayres and John Braithwaite’s Responsive Regulation. This Introduction situates the origins of Responsive Regulation and its vision of transcending the regulation-deregulation debate in the professional biographies of the authors. It goes on to introduce the extensions, critiques and appreciations of responsive regulation offered by the contributors to this special issue by situating them in the rich and ambiguous legacy of Ayres and Braithwaite’s 1992 book. Finally the Introduction points out that the main legacy of responsive regulation is the way it has inspired regulators, social movement advocates and scholars to keep imagining new ways of regulating for the public interest in a context where the boundaries between state, business and civil society is changing so that a predominant reliance on government regulation is no longer seen as legitimate. The Introduction argues that for the future the field of regulatory studies should also include studies that conceptualise and deductively test more specific and particular components of policy oriented theory that might provide the evidence base for responsive regulation, and, importantly, radically inductive critical studies that illuminate the values and interests and power differences that are created by regulation, including regulation inspired by responsive regulation.
The Herschel Multi-tiered Extragalactic Survey: HerMES

The Herschel Multi-tiered Extragalactic Survey (HerMES) is a legacy programme designed to map a set of nested fields totalling ∼380 deg^2. Fields range in size from 0.01 to ∼20 deg^2, using the Herschel-Spectral and Photometric Imaging Receiver (SPIRE) (at 250, 350 and 500 μm) and the Herschel-Photodetector Array Camera and Spectrometer (PACS) (at 100 and 160 μm), with an additional wider component of 270 deg^2 with SPIRE alone. These bands cover the peak of the redshifted thermal spectral energy distribution from interstellar dust and thus capture the reprocessed optical and ultraviolet radiation from star formation that has been absorbed by dust, and are critical for forming a complete multiwavelength understanding of galaxy formation and evolution. The survey will detect of the order of 100 000 galaxies at 5σ in some of the best-studied fields in the sky. Additionally, HerMES is closely coordinated with the PACS Evolutionary Probe survey. Making maximum use of the full spectrum of ancillary data, from radio to X-ray wavelengths, it is designed to facilitate redshift determination, rapidly identify unusual objects and understand the relationships between thermal emission from dust and other processes. Scientific questions HerMES will be used to answer include the total infrared emission of galaxies, the evolution of the luminosity function, the clustering properties of dusty galaxies and the properties of populations of galaxies which lie below the confusion limit through lensing and statistical techniques. This paper defines the survey observations and data products, outlines the primary scientific goals of the HerMES team, and reviews some of the early results.
IgG4‐related disease presenting as recurrent mastoiditis

IgG4-related disease (IgG4-RD) is a recently recognized disorder characterized by an overabundance of IgG4-positive plasma cells in affected tissues and, frequently, elevated serum IgG4 levels. First recognized in the context of autoimmune pancreatitisi, IgG4-RD presents as either a localized area of involvement within a single organ or as a multicentric disease, affecting several organs. Those organs include the pancreas, gallbladder, salivary glands, retroperitoneum, kidneys, lungs, prostate, ocular adnexaii, maxillary sinus, ethmoid sinusiii, lacrimal glands, breast, liver, large blood vessels, mediastinum, lymph nodesiv, pituitaryv, esophagusvi, and dura matervii. The histopathology of IgG4-RD involves a lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis. The disease process generally destroys the normal tissue architecture and replaces it with fibrotic tissue, creating a variety of histologic patterns. The appearance can be pseudolymphomatous (characterized by a dense infiltrate of small lymphocytes), sclerosing (characterized by fibrosis with some areas of lymphocyte aggregates), or mixed (characterized by fibrosis, plasma cells, and lymphocytic infiltrates)viii. IgG4-RD lesions can progress by infiltrating the surrounding tissues or by expanding as a space-occupying mass. The lesions are often exquisitely sensitive to glucocorticoids, but long-term, prospective therapeutic trials are lacking. We hereby describe a patient with IgG4-RD manifesting as recurrent inflammatory disease of the middle ear and mastoid, complicated by bone erosion.
OBSERVATIONS OF DARK AND LUMINOUS MATTER: THE RADIAL DISTRIBUTION OF SATELLITE GALAXIES AROUND MASSIVE RED GALAXIES

We study the projected radial distribution of satellite galaxies around more than 28,000 luminous red galaxies (LRGs) at 0.28 < z < 0.40 and trace the gravitational potential of LRG groups in the range 15 < r/kpc < 700. We show that at large radii the satellite number-density profile is well fitted by a projected Navarro–Frenk–White (NFW) profile with rs ∼ 270 kpc and that at small radii this model underestimates the number of satellite galaxies. Utilizing the previously measured stellar light distribution of LRGs from deep imaging stacks, we demonstrate that this small-scale excess is consistent with a non-negligible baryonic mass contribution to the gravitational potential of massive groups and clusters. The combined NFW+scaled stellar profile provides an excellent fit to the satellite number-density profile all the way from 15 kpc to 700 kpc. Dark matter dominates the total mass profile of LRG halos at r > 25 kpc whereas baryons account for more than 50% of the mass at smaller radii. We calculate the total dark-to-baryonic mass ratio and show that it is consistent with measurements from weak lensing for environments dominated by massive early-type galaxies. Finally, we divide the satellite galaxies in our sample into three luminosity bins and show that the satellite light profiles of all brightness levels are consistent with each other outside of roughly 25 kpc. At smaller radii we find evidence for a mild mass segregation with an increasing fraction of bright satellites close to the central LRG.
The Impact of Work-Family Conflict on Social Work and Human Service Worker Job Satisfaction and Organizational Commitment

Abstract The job stress literature for social workers has grown dramatically during the past twenty years, and it has shown that social service workers suffer from a significant amount of stress; however, Work-Family Conflict (WFC) is a stressor which has received little, if any, attention. WFC occurs when problems from work spillover in family life and vice versa, causing conflict. The four main types of WFC are family-based conflict (when problems at home spillover to work), time-based (when time at work takes away from family life), strain-based (when stress and strain from work causes problems at home), and behavior-based (when work roles cause problems at home or when home roles cause problems at work). This study examined the impact of different types of WFC on the job satisfaction and organizational commitment of social and human service workers. A survey of social and human service employees in Northwest Ohio was conducted in the Fall of 2002, and 255 surveys were returned. It was found that time-based conflict and behavior-based conflict had significant effects on job satisfaction, while strain-based conflict, and family-based conflict did not. Only behavior-based conflict had a significant impact on organizational commitment.
L'économie Néo-Institutionnelle

[eng] Mainstream economics has become increasingly abstract over time. It is little concerned with what happens in the real economic system, and is dedicated to the analysis of choices (whatever the purpose of these choices). To the opposite, New Institutional Economics is concentrated on the main subject of economic analysis : the flows of goods and services. These flows are depending upon the institutions, that result themselves from complex evolutionary and interactive processes. The study of complex interrelated structures is the economists' research agenda for the coming years. [fre] Le courant dominant de l'analyse economique s'est eloigne de son objet d'etude pour se concentrer sur le developpement d'outils analytiques destines a rendre compte des choix. L'economie neo-institutionnelle se caracterise au contraire par la volonte de se concentrer sur l'objet d'etude des economistes : les flux de biens et services. Ces flux dependent de maniere cruciale des institutions qui elles-memes resultent de processus d'evolutions et d'interactions complexes. L'etude des multiples relations d'interdependances en cause constitue le programme de travail des economistes pour les prochaines annees.
Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome

Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying more important positions than others and thus being likely to be under stronger selective pressures. However, how positive selection distributes across the different parts of molecular networks is still not fully understood. Here, we inferred positive selection using comparative genomics and population genetics approaches through the comparison of 10 mammalian and 270 human genomes, respectively. In agreement with previous results, we found that genes with lower network centralities are more likely to evolve under positive selection (as inferred from divergence data). Surprisingly, polymorphism data yield results in the opposite direction than divergence data: Genes with higher centralities are more likely to have been targeted by recent positive selection during recent human evolution. Our results indicate that the relationship between centrality and the impact of adaptive evolution highly depends on the mode of positive selection and/or the evolutionary time-scale.
SOD2 Mediates Amifostine-Induced Protection against Glutamate in PC12 Cells

Background. Cytoprotectant amifostine attenuates radiation-induced oxidative injury by increasing intracellular manganese superoxide dismutase (SOD2) in peripheral tissue. However, whether amifostine could protect neuronal cells against oxidative injury has not been reported. The purpose of this study is to explore the protection of amifostine in PC12 cells. Methods. PC12 cells exposed to glutamate were used to mimic neuronal oxidative injury. SOD assay kit was taken to evaluate intracellular Cu/Zn SOD (SOD1) and SOD2 activities; western blot analysis and immunofluorescence staining were performed to investigate SOD2 protein expression; MTT, lactate dehydrogenase (LDH), release and cell morphology were used to evaluate cell injury degree, and apoptotic rate and cleaved caspase-3 expression were taken to assess apoptosis; mitochondrial superoxide production, intracellular reactive oxygen species (ROS), and glutathione (GSH) and catalase (CAT) levels were evaluated by reagent kits. Results. Amifostine increased SOD2 activity and expression, decreased cell injury and apoptosis, reduced mitochondrial superoxide production and intracellular ROS generation, and restored intracellular GSH and CAT levels in PC12 cells exposed to glutamate. SOD2-siRNA, however, significantly reversed the amifostine-induced cytoprotective and antioxidative actions. Conclusion. SOD2 mediates amifostine-induced protection in PC12 cells exposed to glutamate.
Passively mode-locked diode-pumped surface-emitting semiconductor laser

A surface-emitting semiconductor laser has been passively mode locked in an external cavity incorporating a semiconductor saturable absorber mirror. The gain medium consists of a stack of 12 InGaAs-GaAs strained quantum wells, grown above a Bragg mirror structure, and pumped optically by a high-brightness diode laser. The mode-locked laser emits pulses of 22-ps full-width at half maximum duration at 1030 nm, with a repetition rate variable around 4.4 GHz.
Relationships between Self-Concept Measures and Social Network Characteristics for Black Adolescents

This study explores the relationship among social network structure and support characteristics and between these network characteristics and several self-concept dimensions for 343 middle-income black adolescents. Relationships between the family and the friend portions of the network are also examined. Each adolescent completed the 1 1/2 hour Social Network Record which uses graphic and questionnaire stimulus materials to allow respondents to describe how their social relations are organized and function to provide emotional and material support. Network scales are related to factor scores of the Coopersmith Self-Esteem Inventory, to the Ziller nonverbal "identification with others" tasks and to three semantic differential scales designed to assess the adolescents' perception of how parents, male friends and female friends "see" them. Network size, frequency of contact with members and the average length of time members have been known are highly related while density is unrelated to any other structural score. The relationship between the proximity of family members and frequency of contact with them is very high and positive although this is not the case for the analogous friend measures. While network structure measures are more related to "how others see me" self-judgments and to a measure of social affiliation, the support scales are more related to overall self-esteem. The usefulness of a social network analysis for understanding the social interaction basis of the self-concept during adolescence is discussed.
A Statistical Framework for Improved Automatic Flaw Detection in Nondestructive Evaluation Images

ABSTRACT Nondestructive evaluation (NDE) techniques are widely used to detect flaws in critical components of systems like aircraft engines, nuclear power plants, and oil pipelines to prevent catastrophic events. Many modern NDE systems generate image data. In some applications, an experienced inspector performs the tedious task of visually examining every image to provide accurate conclusions about the existence of flaws. This approach is labor-intensive and can cause misses due to operator ennui. Automated evaluation methods seek to eliminate human-factors variability and improve throughput. Simple methods based on peak amplitude in an image are sometimes employed and a trained-operator-controlled refinement that uses a dynamic threshold based on signal-to-noise ratio (SNR) has also been implemented. We develop an automated and optimized detection procedure that mimics these operations. The primary goal of our methodology is to reduce the number of images requiring expert visual evaluation by filtering out images that are overwhelmingly definitive on the existence or absence of a flaw. We use an appropriate model for the observed values of the SNR-detection criterion to estimate the probability of detection. Our methodology outperforms current methods in terms of its ability to detect flaws. Supplementary materials for this article are available online.
Gastroesophageal Reflux Disease: Attachment Style and Parental Bonding

The attachment styles and parental bonding of 72 patients (M age = 45.3 yr., SD = 13.5) suffering from Gastroesophageal Reflux Disease were compared with those of 105 healthy subjects (M age = 44.9 yr., SD = 5.8). A clinical interview and two questionnaires, the Attachment Style Questionnaire and the Parental Bonding Instrument, showed that the scores on the ASQ Confidence subscale were significantly lower in the clinical group. Similar results were obtained for the Discomfort with Closeness subscale in the subsample with Pure Gastroesophageal Reflux Disease. The results indicate Insecure Attachment in the clinical sample. The results obtained from the Parental Bonding Instrument indicate that scores on the Protection Mother scale were significantly higher in the clinical subjects, suggesting a Low Care–High Protection combination (Affectiveless Control), at least for patients with pure Gastroesophageal Reflux Disease. These characteristics can be considered important factors in the tendency to somatization. The symptoms may have a paradoxically normalising function while the patient shows an emotional detachment towards intimate relationships. The illness appears to act as a bond through which the relationship with the caregivers is maintained.
Looks can be deceiving: recent insights into the mechanism of protein secretion by the autotransporter pathway

Autotransporters are a large superfamily of cell surface proteins produced by Gram‐negative bacteria that consist of an N‐terminal extracellular domain (‘passenger domain’) and a C‐terminal β‐barrel domain that resides in the outer membrane (OM). Although it was originally proposed that the passenger domain is translocated across the OM through a channel formed exclusively by the covalently linked β‐barrel domain, this idea has been strongly challenged by a variety of observations. Recent experimental results have suggested a new model in which both the translocation of the passenger domain and the membrane integration of the β‐barrel domain are facilitated by the Bam complex, a highly conserved heteroligomer that plays a general role in OM protein assembly. Other factors, including periplasmic chaperones and inner membrane proteins, have also recently been implicated in the biogenesis of at least some members of the autotransporter superfamily. New results have raised intriguing questions about the energetics of the secretion reaction and the relationship between the assembly of autotransporters and the assembly of other classes of OM proteins. Concomitantly, new mechanistic and structural insights have expanded the utility of the autotransporter pathway for the surface display of heterologous peptides and proteins of interest.
The impact of baryonic physics on the structure of dark matter haloes: the view from the FIRE cosmological simulations

We study the distribution of cold dark matter (CDM) in cosmological simulations from the FIRE (Feedback In Realistic Environments) project, for M_* ∼ 10^(4–11) M_⊙ galaxies in M_h ∼ 10^(9–12) M_⊙ haloes. FIRE incorporates explicit stellar feedback in the multiphase interstellar medium, with energetics from stellar population models. We find that stellar feedback, without ‘fine-tuned’ parameters, greatly alleviates small-scale problems in CDM. Feedback causes bursts of star formation and outflows, altering the DM distribution. As a result, the inner slope of the DM halo profile (α) shows a strong mass dependence: profiles are shallow at M_h ∼ 10^(10)–10^(11) M_⊙ and steepen at higher/lower masses. The resulting core sizes and slopes are consistent with observations. This is broadly consistent with previous work using simpler feedback schemes, but we find steeper mass dependence of α, and relatively late growth of cores. Because the star formation efficiency M_*/M_h is strongly halo mass dependent, a rapid change in α occurs around M_h ∼ 10^(10) M_⊙ (M_* ∼ 10^6–10^7 M_⊙), as sufficient feedback energy becomes available to perturb the DM. Large cores are not established during the period of rapid growth of haloes because of ongoing DM mass accumulation. Instead, cores require several bursts of star formation after the rapid build-up has completed. Stellar feedback dramatically reduces circular velocities in the inner kpc of massive dwarfs; this could be sufficient to explain the ‘Too Big To Fail’ problem without invoking non-standard DM. Finally, feedback and baryonic contraction in Milky Way-mass haloes produce DM profiles slightly shallower than the Navarro–Frenk–White profile, consistent with the normalization of the observed Tully–Fisher relation.
The ASTOOT approach to testing object-oriented programs

This article describes a new approach to the unit testing of object-oriented programs, a set of tools based on this approach, and two case studies. In this approach, each test case consists of a tuple of sequences of messages, along with tags indicating whether these sequences should put objects of the class under test into equivalent states and/or return objects that are in equivalent states. Tests are executed by sending the sequences to objects of the class under test, then invoking a user-supplied equivalence-checking mechanism. This approach allows for substantial automation of many aspects of testing, including test case generation, test driver generation, test execution, and test checking. Experimental prototypes of tools for test generation and test execution are described. The test generation tool requires the availability of an algebraic specification of the abstract data type being tested, but the test execution tool can be used when no formal specification is available. Using the test execution tools, case studies involving execution of tens of thousands of test cases, with various sequence lengths, parameters, and combinations of operations were performed. The relationships among likelihood of detecting an error and sequence length, range of parameters, and relative frequency of various operations were investigated for priority queue and sorted-list implementations having subtle errors. In each case, long sequences tended to be more likely to detect the error, provided that the range of parameters was sufficiently large and likelihood of detecting an error tended to increase up to a threshold value as the parameter range increased.
Deaf Culture and Competing Discourses in a Residential School for the Deaf: “Can Do” Versus “Can't Do”

From an ethnographic case study of a state-funded residential school for the Deaf, the authors employed Critical Discourse Analysis to identify competing discourses in the talk of educators. These discourses are embedded in the historical oppression and labeling of deaf people as disabled and the development of Deaf culture as a counter-discourse. Implications include changing teacher/administrator hiring practices, improving professional development options, and distributing power between Deaf and hearing educators.
Examiners' Errors on the Wechsler Memory Scale—Revised

This study examined the nature of WMS–R scoring errors made by trainee psychologists and the extent to which errors influenced index scores on this scale Trainee psychologists undertook competency based training exercises for the WMS–R, similar to those devised for the WAIS–R by Fantuzzo, Blakely, and Gorsuch in 1989. A WMS–R training protocol was devised and scored by three experienced psychologists to generate a gold standard protocol. The training protocol was then given to trainee psychologists to score. Scoring errors made by trainees included mathematical and transcription errors, and errors of judgment given failure to apply scoring criteria correctly. Present results are consistent with previous investigations of scoring errors among trainees on Wechsler's intelligence tests, and findings provide a preliminary indication that scoring errors on the WMS–R may alter classification by ability.