Miracle-dz/UniFAR-FTUs huggingface dataset:
Global Gradients of Coral Exposure to Environmental Stresses and Implications for Local Management

Background The decline of coral reefs globally underscores the need for a spatial assessment of their exposure to multiple environmental stressors to estimate vulnerability and evaluate potential counter-measures. Methodology/Principal Findings This study combined global spatial gradients of coral exposure to radiation stress factors (temperature, UV light and doldrums), stress-reinforcing factors (sedimentation and eutrophication), and stress-reducing factors (temperature variability and tidal amplitude) to produce a global map of coral exposure and identify areas where exposure depends on factors that can be locally managed. A systems analytical approach was used to define interactions between radiation stress variables, stress reinforcing variables and stress reducing variables. Fuzzy logic and spatial ordinations were employed to quantify coral exposure to these stressors. Globally, corals are exposed to radiation and reinforcing stress, albeit with high spatial variability within regions. Based on ordination of exposure grades, regions group into two clusters. The first cluster was composed of severely exposed regions with high radiation and low reducing stress scores (South East Asia, Micronesia, Eastern Pacific and the central Indian Ocean) or alternatively high reinforcing stress scores (the Middle East and the Western Australia). The second cluster was composed of moderately to highly exposed regions with moderate to high scores in both radiation and reducing factors (Caribbean, Great Barrier Reef (GBR), Central Pacific, Polynesia and the western Indian Ocean) where the GBR was strongly associated with reinforcing stress. Conclusions/Significance Despite radiation stress being the most dominant stressor, the exposure of coral reefs could be reduced by locally managing chronic human impacts that act to reinforce radiation stress. Future research and management efforts should focus on incorporating the factors that mitigate the effect of coral stressors until long-term carbon reductions are achieved through global negotiations.
State estimation for a humanoid robot

This paper introduces a framework for state estimation on a humanoid robot platform using only common proprioceptive sensors and knowledge of leg kinematics. The presented approach extends that detailed in prior work on a point-foot quadruped platform by adding the rotational constraints imposed by the humanoid's flat feet. As in previous work, the proposed Extended Kalman Filter accommodates contact switching and makes no assumptions about gait or terrain, making it applicable on any humanoid platform for use in any task. A nonlinear observability analysis is performed on both the point-foot and flat-foot filters and it is concluded that the addition of rotational constraints significantly simplifies singular cases and improves the observability characteristics of the system. Results on a simulated walking dataset demonstrate the performance gain of the flat-foot filter as well as confirm the results of the presented observability analysis.
Innovations Drive the Enterprises to Sustainable Development: An Empirical Research on Delixi-Electric Co. Ltd in WenZhou

Management innovation is the key element for an enterprise's sustainable development, which determines whether an enterprise can stand out in the fierce competition of 21st century, and develop rapidly so as to keep an enterprise sustainable running. Through empirical research on innovative management of Delixi-electric Co.Ltd, a Sino-French joint venture, this article summarizes the practice of the enterprise values rebuilt, the new brand promotion and supply chain management innovation as well as its effect.
Predicting Pesticide Transport in Mulch‐Amended Soils

With adoption of combine harvest technology, massive sugarcane (Saccharum Spp. Hyb.) residue is left on the soil surface following each harvest, which could affect the environmental fate and efficacy of applied pesticides in subsequent cropping seasons. The objective of this study was to quantify the retention characteristics and mobility of a commonly used herbicide, atrazine (2-chloro-4-ethylamine-6-isopropylamino-S-triazine), in soils when sugarcane mulch residue was present. Specifically, adsorption and desorption kinetic batch experiments were performed to quantify atrazine retention by the mulch residue over time. Atrazine sorption exhibited time-dependent behavior and was followed by slow release regardless of input concentration. A kinetic-equilibrium model based on a second-order two-site (SOTS) formulation was successful in describing atrazine adsorption versus time by the mulch residue. One set of model parameters was capable of describing atrazine release based on six successive desorption steps. As a test for the applicability of the model, data sets from two other experiments where sorption and release was measured for extended time periods (1348 and 2476 h) were successfully predicted by the SOTS model. Miscible displacement methods were used to measure the mobility of atrazine in packed columns where the mulch residue was mixed with a reference sand material or a Sharkey clay soil (very fine, smectitic, thermic Chromic Epiaquerts). Use of batch-measured model parameters did not adequately describe atrazine mobility in the sand-mulch column. In contrast, for a Sharkey-mulch soil column, a two-compartment SOTS model was successful in predicting atrazine breakthrough results where independently estimated parameters for the mulch residue and the soil matrix were used as the input parameters. Results also showed that mixing of mulch with soil created physical non-equilibrium condition in the columns, which was responsible for errors in model predictions.
Ellipsoid-Constrained Robust Fitting of Quadrics with Application to the 3D Morphological Characterization of Articular Surfaces

This paper addresses the ellipsoid-type-specified fitting of quadratic surfaces, in the scope of model-based global feature extraction within scattered 3D point clouds. At characterizing articular bone surfaces, the quadrics estimated indicate useful overall-symmetry-related intrinsic centers and axes in joints. A constrained weighted least-squares minimization of algebraic residuals is used, with a robust and bias-corrected metric. With only one quadratic constraint involved, every step produces closed-form eigenvector solutions. To guarantee that an ellipsoid is output, we originally exploit a 2D representation called the quadric shape map (QSM) by carrying out a visual study of the influence of shape constraints. The identified ellipsoid guarantee is needed to extract the center and axes in a wrist joint data stemming from 3D medical images.
Exploiting a Probabilistic Hierarchical Model for Generation

Previous stochastic approaches to generation do not include a tree-based representation of syntax. While this may be adequate or even advantageous for some applications, other applications profit from using as much syntactic knowledge as is available, leaving to a stochastic model only those issues that are not determined by the grammar. We present initial results showing that a tree-based model derived from a tree-annotated corpus improves on a tree model derived from an unannotated corpus, and that a tree-based stochastic model with a hand-crafted grammar outperforms both.
Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best?

OBJECTIVE To assess the effects of different doses of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in patients with septic shock. DESIGN Prospective, randomized, open-label study. SETTING A 31-bed, medicosurgical intensive care unit of a university hospital. PATIENTS Convenience sample of 20 patients with septic shock, separated into two groups according to whether (moderate shock group, n = 10) or not (severe shock, n = 10) dopamine alone was able maintain mean arterial pressure >65 mm Hg. INTERVENTIONS Dopamine was progressively withdrawn and replaced successively by norepinephrine and then epinephrine (the order of the two agents was randomly determined) to maintain mean arterial pressure constant (moderate shock) or to increase mean arterial pressure above 65 mm Hg (severe shock). MEASUREMENTS AND MAIN RESULTS Systemic circulation (pulmonary artery catheter) and splanchnic circulation (indocyanine green dilution and hepatic vein catheter) and gastric mucosal Pco(2) (gas tonometry) were measured during dopamine (moderate shock only), norepinephrine, and epinephrine administration (both groups). Data were analyzed with nonparametric tests and are presented as median [percentiles 25-75]. In moderate shock, cardiac index was similar to dopamine and norepinephrine (3.1 [2.7-3.8] vs. 2.9 [2.7-4.1] L/min.m2, p = nonsignificant) but greater with epinephrine (4.1 [3.5-4.4] p <.01 vs. dopamine and norepinephrine). Splanchnic blood flow was similar with the three agents (732 [413-1483] vs. 746 [470-1401] vs. 653 [476-1832] mL/min.m, p = nonsignificant). The gradient between mixed-venous and hepatic venous oxygen saturations was lower with dopamine than with norepinephrine and epinephrine, but the Pco(2) gap was similar with the three agents. In severe shock, cardiac index was higher, but splanchnic blood flow was lower, with epinephrine than with norepinephrine (4.6 [3.7-5.3] vs. 3.4 [3.0-4.1] L/min.m2, p <.01 and 860 [684-1334] vs. 977 [806-1802] mL/min.m2, p <.05, respectively). Epinephrine increased the mixed-venous and hepatic venous oxygen saturation gradient but did not alter Pco(2) gap. CONCLUSIONS Dopamine and norepinephrine have similar hemodynamic effects, but epinephrine can impair splanchnic circulation in severe septic shock.
Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation

Diabetic nephropathy (DN) is a major complication of diabetes and the leading cause of end‐stage renal disease. DN is characterized by changes in kidney structure and function but the underlying genetic and molecular factors are poorly understood. We used a mouse diversity panel to explore the genetic basis of DN traits in mice carrying the Ins2 Akita mutation. Twenty‐eight Akita strains were generated by breeding this panel to DBA/2.Akita mice. Male F1 diabetic and nondiabetic littermates were evaluated for DN‐related traits. Urine albumin‐to‐creatinine ratios (ACRs), volume and cystatin C as well as blood urea nitrogen and lipoprotein levels varied significantly among the diabetic strains. For most Akita strains, ACR values increased 2‐ to 6‐fold over euglycemic control values. However, six strains exhibited changes in ACR exceeding 10‐fold with two strains (NOD/ShiLt and CBA) showing 50‐ to 83‐ fold increases. These increases are larger than previously reported among available DN mouse models establishing these strains as useful for additional studies of renal function. ACRs correlated with cystatin C (P = 0.0286), a measure of hyperfiltration and an interstitial tubular marker associated with DN onset in humans suggesting that tubule damage as well as podocyte‐stress contributed to reduced kidney function assessed by ACR. Although large changes were seen for ACRs, severe nephropathology was absent. However, glomerular hypertrophy and collagen IV content were found to vary significantly among strains suggesting a genetic basis for early onset features of DN. Our results define the range of DN phenotypes that occur among common inbred strains of mice.
Obesity, arterial function and arterial structure – a systematic review and meta‐analysis

Obesity is an established risk factor for cardiovascular disease. The mechanisms by which obesity affects cardiovascular risk have not been fully elucidated. This paper reports a comprehensive systematic review and meta‐analysis on obesity and two key aspects of vascular health using gold‐standard non‐invasive measures – arterial endothelial function (brachial flow‐mediated dilatation) and subclinical atherosclerosis (carotid intima‐media thickness).
Intermittency in the Photosphere and Corona above an Active Region

Recent studies have demonstrated without doubt that the magnetic field in the photosphere and corona is an intermittent structure, opening new views of the underlying physics. In particular, such problems as the existence in the corona of localized areas with extremely strong resistivity (required to explain magnetic reconnection at all scales) and the interchange between small and large scales (required in the study of photospheric-coronal coupling), to name a few, can be easily captured by the concept of intermittency. This study focuses on simultaneous time variations of intermittency properties derived in the photosphere, chromosphere, and corona. We analyze data for NOAA Active Region 10930 acquired between 2006 December 8, 12:00 UT, and December 13, 18:45 UT. Photospheric intermittency is inferred from Hinode magnetic field measurements, while intermittency in the transition region and corona is derived from Nobeyama 9 GHz radio polarization measurements and high-cadence Hinode XRT (thin-Be) data, as well as GOES 1-8 Å flux. The photospheric dynamics and its possible relationship with the intermittency variations are also analyzed by calculating the kinetic vorticity. In this case study, we find the following chain of events: The intermittency of the photospheric magnetic field peaked after the specific kinetic vorticity of plasma flows in the active region reached its maximum (4 hr time delay). In turn, a gradual increase of coronal intermittency occurred after the peak of the photospheric intermittency. The time delay between the peak of photospheric intermittency and the occurrence of the first strong (X3.4) flare was approximately 1.3 days. Our analysis seems to suggest that the enhancement of intermittency/complexity first occurs in the photosphere and is later transported toward the corona.
Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress

Cancer cells are metabolically stressed during tumour progression due to limited tumour vascularity and resultant nutrient, growth factor and oxygen deficiency that can induce cell death and inhibit tumour growth. We demonstrate that Rab25, a small GTPase involved in endosomal recycling, that is genomically amplified in multiple tumour lineages, is a key regulator of cellular bioenergetics and autophagy. RAB25 enhanced survival during nutrient stress by preventing apoptosis and autophagy via binding and activating AKT leading to increased glucose uptake and improved cellular bioenergetics. Unexpectedly, Rab25 induced the accumulation of glycogen in epithelial cancer cells, a process not previously identified. Strikingly, an increase in basal ATP levels combined with AKT‐dependent increases in glucose uptake and glycogen storage allowed maintenance of ATP levels during bioenergetic stress. The clinical relevance of these findings was validated by the ability of a Rab25‐dependent expression profile enriched for bioenergetics targets to identify patients with a poor prognosis. Thus, Rab25 is an unexpected regulator of cellular bioenergetics implicated as a useful biomarker and potential therapeutic target.
The Hes gene family: repressors and oscillators that orchestrate embryogenesis

Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The mammalian Hes basic helix-loop-helix repressor genes play central roles in these processes by maintaining progenitor cells in an undifferentiated state and by regulating binary cell fate decisions. Hes genes also display an oscillatory expression pattern and control the timing of biological events, such as somite segmentation. Many aspects of Hes expression are regulated by Notch signaling, which mediates cell-cell communication. This primer describes these pleiotropic roles of Hes genes in some developmental processes and aims to clarify the basic mechanism of how gene networks operate in vertebrate embryogenesis.
A Joint Source-Channel Model for Machine Transliteration

Most foreign names are transliterated into Chinese, Japanese or Korean with approximate phonetic equivalents. The transliteration is usually achieved through intermediate phonemic mapping. This paper presents a new framework that allows direct orthographical mapping (DOM) between two different languages, through a joint source-channel model, also called n-gram transliteration model (TM). With the n-gram TM model, we automate the orthographic alignment process to derive the aligned transliteration units from a bilingual dictionary. The n-gram TM under the DOM framework greatly reduces system development effort and provides a quantum leap in improvement in transliteration accuracy over that of other state-of-the-art machine learning algorithms. The modeling framework is validated through several experiments for English-Chinese language pair.
Properties of protective loose‐fill foams

This study compared the performance of eight commercial starch and expanded polystyrene (EPS)-based loose-fill foam products. Density of starch-based foams is higher, by a factor of two to three times, than either EPS-based ones. Compressive stress of most starch-based foams did not differ significantly from 0.0893 MPa value for virgin EPS foam. EPS- and starch-based foams have predominantly a closed and open cellular structure, respectively. Resiliency or elastic recovery of starch-based foams had values between 69.5 and 71.25%, which is about 10% lower than virgin EPS foam. Friability of both starch- and EPS-based foams was between 2 and 6 wt %, but starch-based foams broke into a fine dust, whereas EPS-based foams broke into large fragments. After conditioning at 20, 50, and 80% r.h. , 23°C and 50% r.h. , 35°C, the water content for starch-based foams averaged 6.0, 9.5, 14, and 8.5 wt %, respectively. The mechanical properties of starch-based foams were more sensitive to changes in relative humidity and temperature than EPS-based foams, but the higher amount of absorbed moisture did not compromise its mechanical integrity. © 1998 John Wiley & Sons, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America. J Appl Polym Sci 67:1157–1176, 1998
Depth-Related Gradients of Viral Activity in Lake Pavin

ABSTRACT High-resolution vertical sampling and determination of viral and prokaryotic parameters in a deep volcanic lake shows that in the absence of thermal stratification but within light, oxygen, and chlorophyll gradients, host availability empirically is prevalent over the physical and chemical environments and favors lytic over lysogenic “viral life cycles. ”
State in Apolipoprotein E-Deficient Mice Resulting in a Systemic Proinflammatory Apoptotic Bodies In Vitro and In Vivo, Apolipoprotein E Modulates Clearance of

Apolipoprotein E (apoE) is a 34-kDa glycoprotein involved in lipoprotein transport through interaction with the low-density lipoprotein receptor and related receptors. Recently, it has become clear that apoE binding to its receptors plays a role both in development and in control of the immune system. In this study, we show that apoE modulates the rate of uptake of apoptotic cells by macrophages. In vitro, apoE-deﬁcient macrophages ingest less apoptotic thymocytes (but not latex beads) than wild-type macrophages, and this defect can be corrected by addition of exogenous apoE protein . In vivo , the number of dying macrophages is increased in a range of tissues, including lung and brain. Possibly in response to the larger numbers of persistent apoptotic bodies, the number of live macrophages in these tissues are also increased compared with those of wild-type control mice. In addition to the signiﬁcant changes in macrophage population dynamics we observed, levels of the proinﬂammatory cytokine TNF- (cid:1) and the positive acute phase reactant ﬁbrinogen are also elevated in the livers from apoE-deﬁcient mice. In contrast, neither deletion of the gene encoding the LDL receptor nor cholesterol feeding of wild-type mice affected either the number of apoptotic bodies or the number of live macrophages. We conclude that apoE deﬁciency results in impaired clearance of apoptotic cell remnants and a functionally relevant systemic proinﬂammatory condition in mice, independent of its role in lipoprotein metabolism. Any similar reduction of apoE activity in humans may contribute to the pathogenesis of a wide range of chronic diseases including atherosclerosis, dementia, and osteoporosis. The Journal of Immunology, 2004, 173: 6366–6375.
Recording Process Documentation for Provenance

Scientific and business communities are adopting large-scale distributed systems as a means to solve a wide range of resource-intensive tasks. These communities also have requirements in terms of provenance. We define the provenance of a result produced by a distributed system as the process that led to that result. This paper describes a protocol for recording documentation of a distributed system's execution. The distributed protocol guarantees that documentation with characteristics suitable for accurately determining the provenance of results is recorded. These characteristics are confirmed through a number of proofs based on an abstract state machine formalization.
Word-Sense Disambiguation Using Statistical Models of Roget's Categories Trained on Large Corpora

This paper describes a program that disambiguates English word senses in unrestricted text using statistical models of the major Roget's Thesaurus categories. Roget's categories serve as approximations of conceptual classes. The categories listed for a word in Roget's index tend to correspond to sense distinctions; thus selecting the most likely category provides a useful level of sense disambiguation. The selection of categories is accomplished by identifying and weighting words that are indicative of each category when seen in context, using a Bayesian theoretical framework.Other statistical approaches have required special corpora or hand-labeled training examples for much of the lexicon. Our use of class models overcomes this knowledge acquisition bottleneck, enabling training on unrestricted monolingual text without human intervention. Applied to the 10 million word Grolier's Encyclopedia, the system correctly disambiguated 92% of the instances of 12 polysemous words that have been previously studied in the literature.
Numerical investigation of the tribological performance of micro-dimple textured surfaces under hydrodynamic lubrication

Surface texturing is an important approach for controlling the tribological behavior of friction pairs used in mechanical and biological engineering. In this study, by utilizing the method of three-dimensional computational fluid dynamics (CFD) simulation, the lubrication model of a friction pair with micro-dimple array was established based on the Navier–Stokes equations. The typical pressure distribution of the lubricant film was analyzed. It was found that a positive hydrodynamic pressure is generated in the convergent part of the micro-dimple, while a negative hydrodynamic pressure is generated in the divergent part. With suitable parameters, the total integration of the pressure is positive, which can increase the load-carrying capacity of a friction pair. The effects of the micro-dimple parameters as well as fluid properties on tribological performance were investigated. It was concluded that under the condition of hydrodynamic lubrication, the main mechanism for the improvement in the tribological performance is the combined effects of wedging and recirculation. Within the range of parameters investigated in this study, the optimum texture density is 13%, while the optimum aspect ratio varies with the Reynolds number. For a given Reynolds number, there exists a combination of texture density and aspect ratio at which the optimum tribological performance could be obtained. Conclusions from this study could be helpful for the design of texture parameters in mechanical friction components and even in artificial joints.