Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Robustness of Outcome Bias: No Constraint by Prior Culpability

Research on outcome bias has shown that blame attributions for behavioral decisions depend on the decision's consequences. Five studies of American undergraduates (N = 219, N = 83, N = 62, N = 279, and N = 45, respectively) demonstrated robust outcome effects across a variety of circumstances. A manipulation of prior negligence (Study 1), and attempts to keep prior negligence exceedingly low (Studies 2-4) produced converging results. In Study 5, a within-participants manipulation failed to eradicate outcome effects. Furthermore, outcome effects were not moderated by beliefs in a just world. Across all studies, mediational analyses suggested that participants adjusted estimates of negligence to match outcomes, which in turn led to more outcome-consistent attributions of blame. Study 5 showed that those low in belief in a just world were especially likely to adjust their negligence ratings in this way. These studies demonstrate that outcome effects contravene both the standards for rationality delineated by rational decision theorists, and also the more relaxed standards embodied in established legal doctrine.
Personality, Self‐Efficacy and Functioning in Management Teams: A Contribution to Validation

The relationship between individual difference variables and the contribution to team functioning was examined in 58 members of management teams. Extraversion and self-efficacy for working in teams were related to attraction to the team, which in turn was related to a rating of team effectiveness. Extraversion was also related directly to team effectiveness. The relationship between conscientiousness and team functioning was not clear. The results are considered supportive for the validity of self-efficacy for teams and extraversion as indicators of the ability and propensity of individuals to contribute to the functioning of management teams.
How is disease progress in Friedreich’s ataxia best measured? A study of four rating scales

Background: Friedreich’s ataxia (FRDA), the most common genetic cause of ataxia, is characterised by progressive neurodegeneration and cardiomyopathy. Initial treatments are likely to slow progression rather than reverse morbidity. An appropriate and sensitive scale to measure disease progress is critical to detect the benefit of treatments. Objective: To compare the Friedreich Ataxia Rating Scale (FARS) with other scales proposed as outcome measures for FRDA. Methods: 76 participants were assessed with the FARS and the International Cooperative Ataxia Rating Scale (ICARS) and 72 of these participants were also assessed with the Functional Independence Measure and the Modified Barthel Index. 43 participants had repeat measures at an interval of 12 months. Sensitivity and responsiveness were assessed using the effect size for each measure and the sample size required for a placebo-controlled clinical trial. Results: The FARS showed a high correlation with the other three measures. A significant change in the score over 12 months was detected by the FARS, the International Cooperative Ataxia Rating Scale and the Functional Independence Measure. The FARS had the greatest effect size and requires fewer patients for an equivalently powered study. Conclusions: Of the scales assessed, the FARS is the best to use in clinical trials of FRDA. This is based on effect size, and power calculations that show that fewer participants are required to demonstrate the same effect of an intervention. Further work is required to develop more sensitive and responsive instruments.
Effect of Glutathione Depletion on Antitumor Drug Toxicity (Apoptosis and Necrosis) in U-937 Human Promonocytic Cells

Treatment with the DNA topoisomerase inhibitors etoposide, doxorubicin, and camptothecin, and with the alkylating agents cisplatin and melphalan, caused peroxide accumulation and apoptosis in U-937 human promonocytic cells. Preincubation with the reduced glutathione (GSH) synthesis inhibitorl-buthionine-(S,R)-sulfoximine (BSO) always potentiated peroxide accumulation. However, although GSH depletion potentiated the toxicity of cisplatin and melphalan, occasionally switching the mode of death from apoptosis to necrosis, it did not affect the toxicity of the other antitumor drugs. Hypoxia or preincubation with antioxidant agents attenuated death induction, apoptotic and necrotic, by alkylating drugs. The generation of necrosis by cisplatin could not be mimicked by addition of exogenous H2O2 instead of BSO and was not adequately explained by caspase inactivation nor by a selective fall in ATP content. Treatment with cisplatin and melphalan caused a late decrease in mitochondrial transmembrane potential (ΔΨm), which was much greater during necrosis than during apoptosis. The administration of the antioxidant agents N-acetyl-l-cysteine and butylated hydroxyanisole after pulse treatment with cisplatin or melphalan did not affect apoptosis but attenuated necrosis. Under these conditions, both antioxidants attenuated the necrosis-associated ΔΨm decrease. These results indicate that oxidation-mediated alterations in mitochondrial function regulate the selection between apoptosis and necrosis in alkylating drug-treated human promonocytic cells.
Deep bi-directional recurrent networks over spectral windows

Long short-term memory (LSTM) acoustic models have recently achieved state-of-the-art results on speech recognition tasks. As a type of recurrent neural network, LSTMs potentially have the ability to model long-span phenomena relating the spectral input to linguistic units. However, it has not been clear whether their observed performance is actually due to this capability, or instead if it is due to a better modeling of short term dynamics through the recurrence. In this paper. we answer this question by applying a windowed (truncated) LSTM to conversational speech transcription, and find that a limited context is adequate, and that it is not necessaary to scan the entire utterance. The sliding window approach allows not only incremental (online) recognition with a bidirectional model, but also frame-wise randomization (as opposed to utterance randomization), which results in faster convergence. On the SWBD/Fisher corpus, applying bidirectional LSTM RNNs to spectral windows of about 0.5s improves WER on the Hub5'00 benchmark set by 16% relative compared to our best sequence-trained DNN. On an extended 3850h training set that that also includes lectures, the relative gain becomes 28% (Hub5'00 WER 9.2%). In-house conversational data improves by 12 to 17% relative.
Idiopathic pulmonary hemosiderosis presenting in an adult: A case report and review of the literature

Diffuse alveolar hemorrhage (DAH) is characterized by the presence of hemoptysis, anemia, and the presence of diffuse parenchymal infiltrates on imaging studies. Idiopathic pulmonary hemosiderosis (IPH) is an uncommon cause of diffuse alveolar hemorrhage (DAH) and is classically known to present in childhood. Adult-onset IPH is extremely rare. We report the case of a 48-year-old female patient who presented with hemoptysis and acute hypoxic respiratory failure, requiring intubation and mechanical ventilation. Imaging studies showed diffuse bilateral patchy infiltrates. Bronchoalveolar lavage (BAL) confirmed the diagnosis of DAH. Extensive workup including video-assisted thoracoscopic surgical lung biopsy (VATS) failed to reveal any vasculitis, infectious, immunological or connective tissue disorder, as the underlying cause for DAH. The patient was successfully treated with high-dose steroid therapy.
Metagenes and molecular pattern discovery using matrix factorization

We describe here the use of nonnegative matrix factorization (NMF), an algorithm based on decomposition by parts that can reduce the dimension of expression data from thousands of genes to a handful of metagenes. Coupled with a model selection mechanism, adapted to work for any stochastic clustering algorithm, NMF is an efficient method for identification of distinct molecular patterns and provides a powerful method for class discovery. We demonstrate the ability of NMF to recover meaningful biological information from cancer-related microarray data. NMF appears to have advantages over other methods such as hierarchical clustering or self-organizing maps. We found it less sensitive to a priori selection of genes or initial conditions and able to detect alternative or context-dependent patterns of gene expression in complex biological systems. This ability, similar to semantic polysemy in text, provides a general method for robust molecular pattern discovery.
Automatic extension of non-english wordnets

Lexical taxonomies, such as WordNet, are important resources underlying natural language processing techniques such as machine translation and word-sense disambiguation. However, creating and maintaining such taxonomies manually is a tedious and time-consuming task. This has led to a great deal of interest in automatic methods for retrieving taxonomic relations. Efforts for both manual development of taxonomies and automatic acquisition methods have largely focused on English-language resources. Although WordNets exist for many languages, these are usually much smaller than Princeton WordNet (PWN) [1], the major semantic resource for English. For English, an excellent method has been developed for automatically extending lexical taxonomies. Snow et al. [4] show that it is possible to predict new and precise hypernymhyponym relations from a parsed corpus. Unfortunately, the method cannot be easily applied to other languages, as it relies on existing lexical resources. First, the authors use the large amount of data already contained in the PWN to extract a pattern lexicon and train their hypernym classifier. Second, the authors apply word-sense disambiguation based on an existing sense-tagged corpus. Problems in transferring the method to another language include the small size of non-English WordNets and the lack of sense-tagged corpora in other languages. In this paper we apply the method of [4] to a non-English language (Dutch) for which only a basic WordNet and a parser are available. We find that, without an additional sense-tagged corpus, this approach is highly susceptible to noise due to word sense ambiguity. We propose and evaluate two methods to address this problem.
In Situ Split of the Liver When Portal Venous Embolization Fails to Induce Hypertrophy: A Report of Two Cases

Introduction. Associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been reported as an efficient alternative to portal vein embolization (PVE) to induce growth of the future liver remnant (FLR). This method combines portal vein ligation with splitting of the liver parenchyma. Although shown to be efficient in introducing growth of the FLR and allowing for resection of the deportalized part of the liver one to two weeks after the first operation, this approach carries a significant mortality. Presentation of Case. ALPPS was applied to two elderly patients where PVE failed to stimulate sufficient growth of the FLR. In both cases, subsequent growth of the FLR allowed for successful resection of the liver lesions. The postoperative course was uneventful for both patients. Discussion. In both cases, the growth of the FLR was similar to what was previously reported when ALPPS has been performed, both patients underwent radical resections that would probably not have been safe after only the PVE. Conclusion. ALPPS used as rescue technique when PVE fails to stimulate sufficient growth of the FLR can be expected to deliver similar results as ALPPS “Up front”. These cases also suggest that ALPPS is applicable to the elderly population.
Food Habits, Lifestyle Factors and Mortality among Oldest Old Chinese: The Chinese Longitudinal Healthy Longevity Survey (CLHLS)

There are few studies reporting the association between lifestyle and mortality among the oldest old in developing countries. We examined the association between food habits, lifestyle factors and all-cause mortality in the oldest old (≥80 years) using data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). In 1998/99, 8959 participants aged 80 years and older took part in the baseline survey. Follow-up surveys were conducted every two to three years until 2011. Food habits were assessed using an in-person interview. Deaths were ascertained from family members during follow-up. Cox and Laplace regression were used to assess the association between food habits, lifestyle factors and mortality risk. There were 6626 deaths during 31,926 person-years of follow-up. Type of staple food (rice or wheat) was not associated with mortality. Daily fruit and vegetable intake was inversely associated with a higher mortality risk (hazard ratios (HRs): 0.85 (95% CI (confidence interval) 0.77–0.92), and 0.74 (0.66–0.83) for daily intake of fruit and vegetables, respectively). There was a positive association between intake of salt-preserved vegetables and mortality risk (consumers had about 10% increase of HR for mortality). Fruit and vegetable consumption were inversely, while intake of salt-preserved vegetables positively, associated with mortality risk among the oldest old. Undertaking physical activity is beneficial for the prevention of premature death.
Cognitive representation of personality impressions: Organizational processes in first impression formation.

In three experiments subjects given either impression formation or memory task instructions read a series of behavior descriptions that either did or did not contain a highly distinctive item. In each study subjects given impression formation instructions recalled significantly more items than did subjects in the memory condition. Subjects given impression formation instructions were more likely to recall a distinctive item, but presence of a distinctive item in the stimulus list had little effect on recall of the other items. Results are discussed in terms of the organization of information acquired during the process of impression development.
Understanding the learning styles of students: implications for educators

Aims to understand a group learning style so that teachers can best adapt their teaching style and materials to suit the students. Defines learning styles and briefly covers previous findings in this area. Looks at different types of thinking before covering how to assess learning styles using a questionnaire. Provides some implications for educators and looks at the design of assignments which can be tailored in different ways depending upon the findings.
International Journal of Women's Health Dovepress Cervical Cancer Screening: Knowledge, Health Perception and Attendance Rate among Hong Kong Chinese Women

Purpose: Cervical cancer screening has been consistently shown to be effective in reducing the incidence rate and mortality from cervical cancer. However, cervical screening attendance rates are still far from satisfactory in many countries. Strategies, health promotion and education programs need to be developed with clear evidence of the causes and factors relating to the low attendance rate. The study aims to assess the prediction of cervical screening attendance rate by Chinese women's knowledge about cervical cancer and cervical screening as well as their perception of health. Patients and methods: A survey with self-reported questionnaires was conducted on 385 Chinese women recruited from a community clinic in Hong Kong. Participants were Chinese women, Hong Kong residents, aged 18–65 years, able to read Chinese or English, and were not pregnant. Results: Women aged 37 years or less, with at least tertiary education, who perceived having control over their own health and had better knowledge on risk factors, were more likely to attend cervical cancer screening. Many participants had adequate general knowledge but were unable to identify correct answers on the risk factors. Conclusion: Health promotion efforts need to focus on increasing women's knowledge on risk factors and enhancing their perceived health control by providing more information on the link between screening and early detection with lower incidence rates and mortality from cervical cancer. Cervical cancer is the second most common cancer among women, with about 500,000 new cases and 250,000 deaths each year worldwide. 1 The progression of lesions to invasive cancer is slow and most lesions are asymptomatic but can be detected by cervical screening. 2 Early detection of cervical cancer can lead to a good prognosis resulting in a decrease in the mortality and health care costs; if left untreated, the individual suffers and there are significant adverse effects on the families and the community. 3 Cervical screening attendance is likely to be affected by knowledge of cervical Pap smear screening, the risk factors of cervical cancer, and health perception. Although these factors have been widely studied among North American patients, very limited studies are reported among Asian and particularly Chinese. It is not known whether these factors contribute to the low cervical screening rates in many other countries. This study probes the link between cervical screening rate against Chinese women's
Perception of speech simulating different configurations of hearing loss in normal hearing individuals

The present study aimed at assessing perception of filtered speech that simulated different configurations of hearing loss. The simulation was done by filtering four equivalent lists of a monosyllabic test developed by Shivaprasad for Indian‐English speakers. This was done using the Adobe Audition software. Thirty normal hearing participants in the age range of 17–25 years were evaluated. It was found that all four simulated configurations resulted in word identification scores that were significantly different from each other at the. 001 level. Further, phoneme error analysis was done, which showed place errors were more evident than manner and voicing errors in three of the simulated conditions (gradually falling, sharply falling, and rising configurations). It can be concluded that speech identification scores are dependent on the configuration of the simulated hearing loss. However, further studies need to be carried out on individuals with hearing impairment to determine whether a similar trend exists in them or not.
Performance of database workloads on shared-memory systems with out-of-order processors

Database applications such as online transaction processing (OLTP) and decision support systems (DSS) constitute the largest and fastest-growing segment of the market for multiprocessor servers. However, most current system designs have been optimized to perform well on scientific and engineering workloads. Given the radically different behavior of database workloads (especially OLTP), it is important to re-evaluate key system design decisions in the context of this important class of applications.This paper examines the behavior of database workloads on shared-memory multiprocessors with aggressive out-of-order processors, and considers simple optimizations that can provide further performance improvements. Our study is based on detailed simulations of the Oracle commercial database engine. The results show that the combination of out-of-order execution and multiple instruction issue is indeed effective in improving performance of database workloads, providing gains of 1.5 and 2.6 times over an in-order single-issue processor for OLTP and DSS, respectively. In addition, speculative techniques enable optimized implementations of memory consistency models that significantly improve the performance of stricter consistency models, bringing the performance to within 10--15% of the performance of more relaxed models.The second part of our study focuses on the more challenging OLTP workload. We show that an instruction stream buffer is effective in reducing the remaining instruction stalls in OLTP, providing a 17% reduction in execution time (approaching a perfect instruction cache to within 15%). Furthermore, our characterization shows that a large fraction of the data communication misses in OLTP exhibit migratory behavior; our preliminary results show that software prefetch and writeback/flush hints can be used for this data to further reduce execution time by 12%.
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level

A fundamental question in evolutionary genetics concerns the extent to which adaptive phenotypic convergence is attributable to convergent or parallel changes at the molecular sequence level. Here we report a comparative analysis of hemoglobin (Hb) function in eight phylogenetically replicated pairs of high- and low-altitude waterfowl taxa to test for convergence in the oxygenation properties of Hb, and to assess the extent to which convergence in biochemical phenotype is attributable to repeated amino acid replacements. Functional experiments on native Hb variants and protein engineering experiments based on site-directed mutagenesis revealed the phenotypic effects of specific amino acid replacements that were responsible for convergent increases in Hb-O2 affinity in multiple high-altitude taxa. In six of the eight taxon pairs, high-altitude taxa evolved derived increases in Hb-O2 affinity that were caused by a combination of unique replacements, parallel replacements (involving identical-by-state variants with independent mutational origins in different lineages), and collateral replacements (involving shared, identical-by-descent variants derived via introgressive hybridization). In genome scans of nucleotide differentiation involving high- and low-altitude populations of three separate species, function-altering amino acid polymorphisms in the globin genes emerged as highly significant outliers, providing independent evidence for adaptive divergence in Hb function. The experimental results demonstrate that convergent changes in protein function can occur through multiple historical paths, and can involve multiple possible mutations. Most cases of convergence in Hb function did not involve parallel substitutions and most parallel substitutions did not affect Hb-O2 affinity, indicating that the repeatability of phenotypic evolution does not require parallelism at the molecular level.
Wnt signaling promotes oral but suppresses aboral structures in Hydractinia metamorphosis and regeneration

We studied the role of Wnt signaling in axis formation during metamorphosis and regeneration in the cnidarian Hydractinia. Activation of Wnt downstream events during metamorphosis resulted in a complete oralization of the animals and repression of aboral structures (i.e. stolons). The expression of Wnt3, Tcf and Brachyury was upregulated and became ubiquitous. Rescue experiments using Tcf RNAi resulted in normal metamorphosis and quantitatively normal Wnt3 and Brachyury expression. Isolated, decapitated polyps regenerated only heads but no stolons. Activation of Wnt downstream targets in regenerating animals resulted in oralization of the polyps. Knocking down Tcf or Wnt3 by RNAi inhibited head regeneration and resulted in complex phenotypes that included ectopic aboral structures. Multiple heads then grew when the RNAi effect had dissipated. Our results provide functional evidence that Wnt promotes head formation but represses the formation of stolons, whereas downregulation of Wnt promotes stolons and represses head formation.