Miracle-dz/UniFAR-FTUs huggingface dataset:
Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans

Low‐volume ‘sprint’ interval training (SIT) stimulates rapid improvements in muscle oxidative capacity that are comparable to levels reached following traditional endurance training (ET) but no study has examined metabolic adaptations during exercise after these different training strategies. We hypothesized that SIT and ET would induce similar adaptations in markers of skeletal muscle carbohydrate (CHO) and lipid metabolism and metabolic control during exercise despite large differences in training volume and time commitment. Active but untrained subjects (23 ± 1 years) performed a constant‐load cycling challenge (1 h at 65% of peak oxygen uptake before and after 6 weeks of either SIT or ET (n= 5 men and 5 women per group). SIT consisted of four to six repeats of a 30 s ‘all out’ Wingate Test (mean power output ∼500 W) with 4.5 min recovery between repeats, 3 days per week. ET consisted of 40–60 min of continuous cycling at a workload that elicited ∼65% (mean power output ∼150 W) per day, 5 days per week. Weekly time commitment (∼1.5 versus∼4.5 h) and total training volume (∼225 versus∼2250 kJ week−1) were substantially lower in SIT versus ET. Despite these differences, both protocols induced similar increases (P < 0.05) in mitochondrial markers for skeletal muscle CHO (pyruvate dehydrogenase E1α protein content) and lipid oxidation (3‐hydroxyacyl CoA dehydrogenase maximal activity) and protein content of peroxisome proliferator‐activated receptor‐γ coactivator‐1α. Glycogen and phosphocreatine utilization during exercise were reduced after training, and calculated rates of whole‐body CHO and lipid oxidation were decreased and increased, respectively, with no differences between groups (all main effects, P < 0.05). Given the markedly lower training volume in the SIT group, these data suggest that high‐intensity interval training is a time‐efficient strategy to increase skeletal muscle oxidative capacity and induce specific metabolic adaptations during exercise that are comparable to traditional ET.
Power-aware scheduling for periodic real-time tasks

We address power-aware scheduling of periodic tasks to reduce CPU energy consumption in hard real-time systems through dynamic voltage scaling. Our intertask voltage scheduling solution includes three components: 1) a static (offline) solution to compute the optimal speed, assuming worst-case workload for each arrival, 2) an online speed reduction mechanism to reclaim energy by adapting to the actual workload, and 3) an online, adaptive and speculative speed adjustment mechanism to anticipate early completions of future executions by using the average-case workload information. All these solutions still guarantee that all deadlines are met. Our simulation results show that our reclaiming algorithm alone outperforms other recently proposed intertask voltage scheduling schemes. Our speculative techniques are shown to provide additional gains, approaching the theoretical lower-bound by a margin of 10 percent.
Using self-questioning to promote pupils' process skills thinking

Process skills are an important aspect of scientific enquiry. The ability to ask oneself questions can elicit and promote self-regulated, reflective thinking. Thus, self-questioning that is directed towards the use of process skills offers much potential in fostering critical thinking in pupils. This article presents a framework for self-questioning that could develop pupils' process skills.
Vigilance and Signal Detection Theory: An Empirical Evaluation of Five Measures of Response Bias

Three experiments were conducted to determine which of five response bias indices (β, c, B", B'H and B"D) defined by the theory of signal detection provides the most effective measure of the observer's willingness to respond in a vigilance task. The results indicated that the traditional parametric bias index β was an inadequate measure of response bias in every respect, whereas the newer parametric measure c was the most effective of all five indices. When the three nonparametric measures (B", B'H' and B"D) were examined separately, B"D emerged as the most effective nonparametric index. We recommend that vigilance researchers use c rather than β to measure bias when a parametric model is involved and B"D instead of B" and B' H when a nonparametric model is used.
Using appreciative inquiry in evaluation

SERIES EDITORS' NOTES (Gary T. Henry, Jennifer C. Greene). EDITORS' NOTES (Hallie Preskill, Anne T. Coghlan). 1. An Overview of Appreciative Inquiry in Evaluation (Anne T. Coghlan, Hallie Preskill, Tessie Tzavaras Catsambas) This chapter provides an overview of Appreciative Inquiry and a discussion of why and how it may be used in evaluation practice.2. Appreciative Evaluation Within a Conflicted Educational Context (Sheila McNamee) Appreciative Inquiry was used as part of a schoolwide curriculum reform evaluation process with one department's staff that was having difficulties agreeing on its program's philosophy and curricular changes.3. Using Appreciative Inquiry to Guide an Evaluation of the International Women's Media Foundation Africa Program (Tessie Tzavaras Catsambas, Laverne D. Webb) This chapter examines the benefits and challenges of using Appreciative Inquiry processes to focus an evaluation and to design and conduct several data collection methods.4. Using Appreciative Inquiry to Evaluate Project Activities of a Nongovernmental Organization Supporting Victims of Trauma in Sri Lanka (Mette Jacobsgaard) Appreciative Inquiry was used to evaluate a program that serves victims of torture and trauma.5. Incorporating Appreciative Inquiry Methods to Evaluate a Youth Development Program (Dawn Hanson Smart, Mariann Mann) Using Appreciative Inquiry in conjunction with other evaluation methods helped to identify and confirm a program's theory of change and its long-term expected outcomes. It also provided important information for improving the program.6. Appreciating Appreciative Inquiry (Patricia J. Rogers, Dugan Fraser) This chapter provides a critique of the four case studies in this volume and offers insights into the limitations of using Appreciative Inquiry in evaluation contexts.7. Inquiry into Appreciative Evaluation (Michael Quinn Patton) After comparing Appreciative Inquiry applications in organizational development and evaluation, this chapter focuses on how Appreciative Inquiry adds to the options available to evaluators when seeking to match their evaluation approach to the situation and needs of users.INDEX.
Incidence and Cost of Hospital Admissions Secondary to Drug Interactions Involving Theophylline

OBJECTIVE: To determine the incidence and cost of hospital admissions for theophylline toxicity, which occurred as a result of the concurrent use of one of the following medications: cimetidine, erythromycin, or ciprofloxacin. DESIGN: Retrospective chart review (18 months, between June 1989 and November 1990). SETTING: A Department of Veterans Affairs Medical Center. PARTICIPANTS: All patients who were receiving theophylline chronically (913 patients) and also had a prescription for cimetidine (124 patients with 140 treatment courses), erythromycin (66 patients with 93 treatment courses), or ciprofloxacin (39 patients with 59 treatment courses) dispensed. INTERVENTIONS: Each patient's medical record was reviewed to identify hospital admissions within 30 days following the dispensing of the interacting drug. MAIN OUTCOME MEASURES: Admissions were considered to be related to theophylline toxicity if appropriate signs and symptoms were present and the theophylline concentration was above 20 μg/mL or had increased significantly from the concentration obtained prior to introduction of the interacting drug. RESULTS: One patient who received cimetidine and one who received ciprofloxacin were admitted for theophylline toxicity (2 of 292 potential interactions, 0.81 percent). Admissions were for 16 and 13 days, respectively, and total costs for the two admissions were $12 864.22 or $44.00, respectively, per potential interaction. The entire admission was not for theophylline toxicity; it appeared that iatrogenic factors contributed to the duration. CONCLUSIONS: The incidence of hospital admissions secondary to theophylline drug interactions with cimetidine, ciprofloxacin, or erythromycin is low, but the admissions represent considerable expense, even when distributed among all patients at risk for the interactions.
Tool-supported refactoring for JavaScript

Refactoring is a popular technique for improving the structure of existing programs while maintaining their behavior. For statically typed programming languages such as Java, a wide variety of refactorings have been described, and tool support for performing refactorings and ensuring their correctness is widely available in modern IDEs. For the JavaScript programming language, however, existing refactoring tools are less mature and often unable to ensure that program behavior is preserved. Refactoring algorithms that have been developed for statically typed languages are not applicable to JavaScript because of its dynamic nature. We propose a framework for specifying and implementing JavaScript refactorings based on pointer analysis. We describe novel refactorings motivated by best practice recommendations for JavaScript programming, and demonstrate how they can be described concisely in terms of queries provided by our framework. Experiments performed with a prototype implementation on a suite of existing applications show that our approach is well-suited for developing practical refactoring tools for JavaScript.
Craving for Food in Virtual Reality Scenarios in Non-Clinical Sample: Analysis of its Relationship with Body Mass Index and Eating Disorder Symptoms.

Virtual reality (VR) technology has been successfully used to study the influence of specific and contextual food-related cues on emotional, cognitive and behavioural responses in patients with eating disorders (ED) and healthy controls. Following this research line, the present study assesses the effect on reported food craving of the type of food (low calorie versus high calorie) and the presence or absence of other people (private versus social context) in VR environments. Relationships between craving and body mass index (BMI) and ED symptoms are also explored. Eighty-seven female students were exposed to four VR scenarios presented in random order: a low-calorie kitchen, a high-calorie kitchen, a low-calorie restaurant and a high-calorie restaurant. After 2 minutes of exposure to each virtual scenario, food craving was assessed. Repeated measures analyses of covariance were conducted to assess changes in food craving following exposure to the different VR environments. Time elapsed since the last meal was introduced as a covariate to control for responses produced by food deprivation. Correlation and hierarchical multiple regression analyses were also conducted to assess the relationship between reported food craving and BMI and ED symptoms. Participants experienced higher levels of food craving after exposure to high-calorie foods (in both the kitchen and restaurant environments) than after exposure to low-calorie foods. Being alone in the kitchen or with friends in the restaurant had no effect on reported craving. Overall, neither BMI nor ED symptoms were related with reported food craving; only in the restaurant with low-calorie food was a significant negative correlation found between BMI and food craving. The results suggest that cue exposure in virtual environments is an effective procedure for inducing food craving in healthy controls and may be useful as a research and therapeutic tool in clinical populations.
Multiple conformational switches in a GTPase complex control co-translational protein targeting

The “GTPase switch” paradigm, in which a GTPase switches between an active, GTP-bound state and an inactive, GDP-bound state through the recruitment of nucleotide exchange factors (GEFs) or GTPase activating proteins (GAPs), has been used to interpret the regulatory mechanism of many GTPases. A notable exception to this paradigm is provided by two GTPases in the signal recognition particle (SRP) and the SRP receptor (SR) that control the co-translational targeting of proteins to cellular membranes. Instead of the classical “GTPase switch,” both the SRP and SR undergo a series of discrete conformational rearrangements during their interaction with one another, culminating in their reciprocal GTPase activation. Here, we show that this series of rearrangements during SRP-SR binding and activation provide important control points to drive and regulate protein targeting. Using real-time fluorescence, we showed that the cargo for SRP—ribosomes translating nascent polypeptides with signal sequences—accelerates SRP·SR complex assembly over 100-fold, thereby driving rapid delivery of cargo to the membrane. A series of subsequent rearrangements in the SRP·SR GTPase complex provide important driving forces to unload the cargo during late stages of protein targeting. Further, the cargo delays GTPase activation in the SRP·SR complex by 8–12 fold, creating an important time window that could further improve the efficiency and fidelity of protein targeting. Thus, the SRP and SR GTPases, without recruiting external regulatory factors, constitute a self-sufficient system that provides exquisite spatial and temporal control of a complex cellular process.
The parental experience in midlife

Most adults experience parenthood. The longest period of the parental experience - when children grow into adolescence and young adulthood and parents themselves are not yet elderly - the editors see as the least understood. In this volume, contributors from the fields of anthropology, demography, economics, psychology, social work, and sociology explore the years of midlife parenthood. The authors employ a varied array of theory and methods to address how the parental experience affects the health, well-being, and development of individuals. Collectively, they look at the time when parents watch offspring grow into adulthood and begin to establish adult-to-adult relationships with their children and examine the factors that influence the quality of the midlife parenting experience.
Risk prediction models for hospital readmission: a systematic review.

CONTEXT Predicting hospital readmission risk is of great interest to identify which patients would benefit most from care transition interventions, as well as to risk-adjust readmission rates for the purposes of hospital comparison. OBJECTIVE To summarize validated readmission risk prediction models, describe their performance, and assess suitability for clinical or administrative use. DATA SOURCES AND STUDY SELECTION The databases of MEDLINE, CINAHL, and the Cochrane Library were searched from inception through March 2011, the EMBASE database was searched through August 2011, and hand searches were performed of the retrieved reference lists. Dual review was conducted to identify studies published in the English language of prediction models tested with medical patients in both derivation and validation cohorts. DATA EXTRACTION Data were extracted on the population, setting, sample size, follow-up interval, readmission rate, model discrimination and calibration, type of data used, and timing of data collection. DATA SYNTHESIS Of 7843 citations reviewed, 30 studies of 26 unique models met the inclusion criteria. The most common outcome used was 30-day readmission; only 1 model specifically addressed preventable readmissions. Fourteen models that relied on retrospective administrative data could be potentially used to risk-adjust readmission rates for hospital comparison; of these, 9 were tested in large US populations and had poor discriminative ability (c statistic range: 0.55-0.65). Seven models could potentially be used to identify high-risk patients for intervention early during a hospitalization (c statistic range: 0.56-0.72), and 5 could be used at hospital discharge (c statistic range: 0.68-0.83). Six studies compared different models in the same population and 2 of these found that functional and social variables improved model discrimination. Although most models incorporated variables for medical comorbidity and use of prior medical services, few examined variables associated with overall health and function, illness severity, or social determinants of health. CONCLUSIONS Most current readmission risk prediction models that were designed for either comparative or clinical purposes perform poorly. Although in certain settings such models may prove useful, efforts to improve their performance are needed as use becomes more widespread.
Carbon Biogeochemistry of Ground Water, Guiyang, Southwest China

Variations in the concentrations and isotopic compositions (δ13CDIC) of dissolved inorganic carbon (DIC) reflect contamination and biogeochemical cycling of the carbon in ground water. In order to understand contamination and biogeochemical cycling of DIC, we carried out research on the geochemistry of ground water of Guiyang, the capital city of Guizhou Province, China. Results show that ground water is mainly characterized by SO4·HCO3‐Ca·Mg and HCO3‐Ca·Mg chemical compositions. The hydrochemical characteristics of these types of water are mainly controlled by lithology of the aquifers. HCO3− is the dominant species of DIC in ground water and has lower concentrations and more negative values of δ13CDIC in the high‐flow (summer monsoon) season, as compared to the low‐flow season. This indicates that DIC is relatively enriched in carbon of biological origin in the high‐flow season as compared to the low‐flow season and that biological activities are the predominant control on shifts of stable carbon isotope values. The evidence that the δ13CDIC values of ground water decrease with increasing concentrations of anthropogenic species shows that the carbon isotopic composition of DIC can be a useful tracer of contamination, in addition to biogeochemical cycling of inorganic carbon in ground water. Results from this study show that ground water is impacted by significant levels of contamination from human activities, especially in the urban areas, as well as the northeast and west suburbs, in Guiyang city, southwest China.
Measuring the Impact of Cultural Context on Chinese ESL University Learners’ Comprehension and Memorization of Figurative Idioms

This paper primarily focuses on the description of the results of a study conducted on ten Chinese university students ESL learners to investigate whether or not cultural context has a significant impact on university students’ ability to remember and understand English figurative idioms as part of English as a Second Language instruction in China. Since Idiom is a kind of language block which concord rich cultural elements and the figurative idiom whose meaning cannot be easy inferred by the usual meaning of its constituent elements, so the present study was based on the relationship between culture and language, the origins of the idioms and their cultural connotations. As some scholars’ studies have shown before, knowing the origins and the source domains of the idioms can enhance the learners motivation, then their comprehension and retention of idioms are improved. The present study also demonstrates that the cultural context can facilitate learners understanding and memorization of the English figurative idiom.
A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export

Lantibiotic and non‐lantibiotic bacteriocins are synthesized as precursor peptides containing N‐terminal extensions (leader peptides) which are cleaved off during maturation. Most non‐lantibiotics and also some lantibiotics have leader peptides of the so‐ called double‐glycine type. These leader peptides share consensus sequences and also a common processing site with two conserved glycine residues In positions ‐1 and 2. The double‐glycine‐type leader peptides are unrelated to the N‐terminal signal sequences which direct proteins across the cytoplasmic membrane via the sec pathway. Their processing sites are also different from typical signal peptidase cleavage sites, suggesting that a different processing enzyme is involved. Peptide bacteriocins are exported across the cytoplasmic membrane by a dedicated ATP‐binding cassette (ABC) transporter. Here we show that the ABC transporter is the maturation protease and that its proteolytic domain resides in the N‐terminal part of the protein. This result demonstrates that the ABC transporter has a dual function: (i) removal of the leader peptide from its substrate, and (ii) translocation of its substrate across the cytoplasmic membrane. This represents a novel strategy for secretion of bacterial proteins.
Transcending oneself through social identification

This brief survey of life strategies suggests that a recurrent theme in human beings' struggle with the unbearable finitude of being is the reliance on a community, be it local or imagined. In this chapter we elaborate on this thesis from a social psychological perspective and argue that affiliation to and, more crucially, identification with social groups is ranked high in the repertoire of strategies that human beings use to transcend themselves. Specifically, we contend that through social identification, individuals expand their sense of self in space and time, thus participating in a larger, immaterial, and therefore immortal entity. The development of these ideas is grounded in social identity theory and terror management theory. We begin by outlining the main concepts of these theoretical perspectives before presenting some empirical evidence in support of our thesis.
Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X‐irradiated spinal cord not shared by Schwann cells

Although several studies have shown that Schwann cells (SCs) and olfactory ensheathing cells (OECs) interact differently with central nervous system (CNS) cells in vitro, all classes of adult myelin‐forming cells show poor survival and migration after transplantation into normal CNS. X‐irradiation of the spinal cord, however, selectively facilitates migration of oligodendrocyte progenitor cells (OPCs), but not SCs, revealing differences in in vivo migratory capabilities that are not apparent in intact tissue. To compare the in vivo migratory properties of OECs and SCs and evaluate the potential of migrating cells to participate in subsequent repair, we first transplanted freshly isolated GFP‐expressing adult rat olfactory bulb‐derived OECs and SCs into normal and X‐irradiated spinal cords. Both OECs and SCs showed limited survival and migration in normal spinal cord at 3 weeks. However, OECs, unlike SCs, migrated extensively in both grey and white matter of the X‐irradiated spinal cord, and exhibited a phagocytic phenotype with OX‐42 staining on their processes. If a X‐irradiated and OEC transplanted spinal cord was then subjected to a focal demyelinating lesion 3 weeks after transplantation, OECs moved into the delayed demyelinated lesion and remyelinated host axons with a peripheral‐like pattern of myelin. These results revealed a clear difference between the migratory properties of OECs and SCs in the X‐irradiated spinal cord and demonstrated that engrafted OECs can participate in repair of subsequent lesions. © 2008 Wiley‐Liss, Inc.
Tetraspan and beta‐1 integrins expression pattern of the epithelial lung adenocarcinoma cell line A549 and its sensitivity to divalent cations

Tetraspans are ubiquitous integral transmembrane molecules associated on the cell surface with such adhesion molecules as integrins. Their expression has been shown to vary in tumors, but has seldom been described on lung tumoral epithelial cells, and the conditions required for a proper association of tetraspans and integrins have not yet been fully explored.