Miracle-dz/UniFAR-FTUs huggingface dataset:
Drug Chirality in Anesthesia

MORE than one-third of all synthetic drugs are chiral and are marketed as racemates, 1:1 mixtures of two types of molecules bearing identical chemical constitution and atomic connections but with a different spatial orientation of their constituent atoms. Drug receptors may discriminate between stereoisomers in several ways; binding may favor one form over the other, and to a degree varying with the drug molecule and with the state of the receptor, or stereoisomers may have opposite effects, one form being an agonist at the same receptor where its mirror image is antagonist. Stereoselectivity is interesting from both a scientific and clinical point of view. Scientifically, stereoselective responses give evidence for specific receptor-mediated responses and information about the structure of the binding site. Clinically, the use of single stereoisomers of chiral anesthetic drugs has received increasing attention recently, because it might decrease side effects and increase drug-safety. In this brief review we define some fundamental terms of stereochemistry, introduce the nomenclature for designating the different stereoisomers (enantiomers), present general principles of stereoselective drug action, and describe the possible contributions of pharmacokinetic and pharmacodynamic mechanisms to stereoselective advantages. Finally, three examples of chiral anesthetic drugs are discussed in the above context.
Wear and Friction Characteristics of Magnetorheological Fluid under Magnetic Field Activation

In this article, wear and friction characteristics of a magnetorheological (MR) fluid were studied under different magnetic fields. Using a pin-on-disc tribometer, the wear loss and friction coefficient were obtained with and without a magnetic field. The friction and wear of three typical materials under magnetic field were investigated at various normal loads and rotating speeds. After the wear tests, the worn surfaces of specimens were observed using a scanning electron microscope (SEM) in order to investigate the wear mechanisms, and the contacting surfaces were analyzed by energy-dispersive X-ray spectroscopy (EDS) to investigate the variation of elemental composition on the worn surface. Test results showed that the MR fluid exhibits better tribological characteristics under a magnetic field compared to the case without a magnetic field. The general morphology of the MR particles and wear debris was observed to assist with the analysis of friction and wear. The SEM micrographs and EDS spectra of the worn surfaces showed that the predominant wear mechanism in the case of the steel and brass specimens was abrasive wear by asperities and MR particles on the worn surfaces, whereas a mixed wear mechanism that included adhesive wear and abrasive wear was observed in the case of the aluminum specimen.
Recent Advances in Pulmonary Hypertension

582 It is estimated that >140 million people live above 2500 m in various regions of the world. There are many challenges to living at high altitude, but chronic exposure to alveolar hypoxia is prominent among them. Inspired Po 2 falls from ≈150 mm Hg at sea level to ≈100 mm Hg at 3000 m and 43 mm Hg on the summit of Everest (8400 m). The body responds by hyperventilating, increasing resting heart rate, and stimulating red cell production in an attempt to maintain the oxygen content of arterial blood at or above sea level values. However, hypoxic pulmonary vasoconstriction (HPV) and vascular remodeling, together with increased erythropoiesis, place an increased pressure load on the right ventricle (RV). How well healthy humans adapt to hypoxia depends on their rate of ascent to altitude, the severity and duration of their exposure, and their genetic background.
Low prevalence of irritable bowel syndrome in primary health care in four Swedish counties

Abstract Objective. Few large-scale studies have examined the prevalence of irritable bowel syndrome (IBS) and the number of visits among IBS patients in a primary health care setting. The aim of this study was to assess the prevalence of IBS in primary health care in four Swedish counties. Another aim was to study the number of visits among the IBS patients. Design. A register-based study. Setting. A primary health care database with information on patients from 71 primary health care centres in the Swedish counties of Stockholm, Uppsala, Värmland, and Gotland. Subjects. The primary health care database contains individual-level data for 919 954 patients for the period 2001–2007. Main outcome measures. Prevalence of IBS diagnosis. Results. 10 987 patients had a diagnosis of IBS, which corresponds to a prevalence of 1.2%. IBS was most common in the 25–44 years age group (37% of IBS patients); 71% of IBS patients were female, and 81% of IBS patients visited their GP six or more times, compared with 46% of non-IBS patients. However, 95% of the IBS patients visited their GP three times or fewer for IBS. Conclusion and implications. The prevalence of IBS was low among Swedish primary health care patients. This might suggest that IBS patients are insufficiently diagnosed in Swedish primary health care.
Repeated Use of Surrogate Mothers for Embryo Transfer in the Mouse

ABSTRACT Embryo transfer in mice is a crucial technique for generation of transgenic animals, rederivation of contaminated lines, and revitalization of cryopreserved strains, and it is a key component of assisted reproduction techniques. It is common practice to use females only once as surrogate mothers. However, their reuse for a second embryo transfer could provide hygienic and economic advantages and conform to the concept of the 3Rs (replace, reduce, refine). This investigation evaluated the potential for a second embryo transfer in terms of feasibility, reproductive results, and experimental burden for the animal. Virgin female ICR mice (age 8–16 wk) were used as recipients for the first embryo transfer. Immediately after weaning of the first litter, a second surgical embryo transfer was performed into the same oviduct. Virgin females of comparable age to the reused mothers served as controls and underwent the same procedure. The first surgery did not affect the success of the second embryo transfer. Histological sections showed excellent wound healing without relevant impairment of involved tissues. We observed no differences in pregnancy rates or litter sizes between the transfer groups. Most importantly, we found no change in behavior indicating reduced well-being and no increase of corticosterone metabolites in the feces of surrogate mothers reused for a second embryo transfer. We conclude that a second embryo transfer in mice is feasible with regard to reproductive and animal welfare aspects.
Adaptation and Prosthesis Effects on Stride-to-Stride Fluctuations in Amputee Gait

Twenty-four individuals with transtibial amputation were recruited to a randomized, crossover design study to examine stride-to-stride fluctuations of lower limb joint flexion/extension time series using the largest Lyapunov exponent (λ). Each individual wore a “more appropriate” and a “less appropriate” prosthesis design based on the subject's previous functional classification for a three week adaptation period. Results showed decreased λ for the sound ankle compared to the prosthetic ankle (F1,23 = 13.897, p = 0.001) and a decreased λ for the “more appropriate” prosthesis (F1,23 = 4.849, p = 0.038). There was also a significant effect for the time point in the adaptation period (F2,46 = 3.164, p = 0.050). Through the adaptation period, a freezing and subsequent freeing of dynamic degrees of freedom was seen as the λ at the ankle decreased at the midpoint of the adaptation period compared to the initial prosthesis fitting (p = 0.032), but then increased at the end compared to the midpoint (p = 0.042). No differences were seen between the initial fitting and the end of the adaptation for λ (p = 0.577). It is concluded that the λ may be a feasible clinical tool for measuring prosthesis functionality and adaptation to a new prosthesis is a process through which the motor control develops mastery of redundant degrees of freedom present in the system.
Direct Reciprocity Under Uncertainty Does Not Explain One-Shot Cooperation, But It Can Explain Norm Psychology

Humans in many societies cooperate in economic experiments at much higher levels than would be expected if their goal was maximizing economic returns even when interactions are anonymous and one-shot. This is a puzzle because paying a cost to benefit another player in one-shot interactions has no direct benefit to the cooperator. This paper explores the logic of two competing evolutionary hypotheses to explain this behavior. The “norm psychology” hypothesis holds that a player’s choice of strategy is heavily influenced by socially-learned cultural norms. Its premise is that over the course of human evolutionary history, cultural norms varied considerably across human societies and through a process of gene-culture co-evolution, humans evolved mechanisms to learn and adopt the norms of their particular society. The “evolutionary mismatch” hypothesis holds that pro-social preferences evolved genetically in our hunter-gatherer past where one-shot anonymous interactions were rare and these evolved “protocols” for cooperation are misapplied in modern, laboratory, conditions. I compare these hypotheses by adopting a well-known model of the mismatch hypothesis. I show that the cooperation generated by the model is based on a flawed assumption - that the best thing to do is cooperate in a repeated game. I show that repeated games generate a great diversity of behavioral equilibria, in support of the norm psychology hypothesis’s premise. When interaction is repeated, adopting local norms is a more evolutionarily successful strategy than automatically cooperating. If various groups are at different behavioral equilibria, then cultural selection between groups tends to select for cooperative behavior.
Heterozygous Mutations of FREM1 Are Associated with an Increased Risk of Isolated Metopic Craniosynostosis in Humans and Mice

The premature fusion of the paired frontal bones results in metopic craniosynostosis (MC) and gives rise to the clinical phenotype of trigonocephaly. Deletions of chromosome 9p22.3 are well described as a cause of MC with variably penetrant midface hypoplasia. In order to identify the gene responsible for the trigonocephaly component of the 9p22.3 syndrome, a cohort of 109 patients were assessed by high-resolution arrays and MLPA for copy number variations (CNVs) involving 9p22. Five CNVs involving FREM1, all of which were de novo variants, were identified by array-based analyses. The remaining 104 patients with MC were then subjected to targeted FREM1 gene re-sequencing, which identified 3 further mutant alleles, one of which was de novo. Consistent with a pathogenic role, mouse Frem1 mRNA and protein expression was demonstrated in the metopic suture as well as in the pericranium and dura mater. Micro-computed tomography based analyses of the mouse posterior frontal (PF) suture, the human metopic suture equivalent, revealed advanced fusion in all mice homozygous for either of two different Frem1 mutant alleles, while heterozygotes exhibited variably penetrant PF suture anomalies. Gene dosage-related penetrance of midfacial hypoplasia was also evident in the Frem1 mutants. These data suggest that CNVs and mutations involving FREM1 can be identified in a significant percentage of people with MC with or without midface hypoplasia. Furthermore, we present Frem1 mutant mice as the first bona fide mouse model of human metopic craniosynostosis and a new model for midfacial hypoplasia.
Graph Laplacians and Stabilization of Vehicle Formations

Control of vehicle formations has emerged as a topic of significant interest to the controls community. In this paper, we merge tools from graph theory and control theory to derive stability criteria for formation stabilization. The interconnection between vehicles (i.e., which vehicles are sensed by other vehicles) is modeled as a graph, and the eigenvalues of the Laplacian matrix of the graph are used in stating a Nyquist-like stability criterion for vehicle formations. The location of the Laplacian eigenvalues can be correlated to the graph structure, and therefore used to identify desirable and undesirable formation interconnection topologies.
Are posttherapy radioiodine scans informative and do they influence subsequent therapy of patients with differentiated thyroid cancer?

UNLABELLED Posttherapy scans (PTS) with a gamma camera are typically used after therapeutic doses of 131I to visualize metastases that may not be seen with lower dose diagnostic scans. During a 16-month period, we studied 81 patients (64 with papillary thyroid cancer and 17 with follicular thyroid cancer), who had both a diagnostic whole-body scan (131I dose 3 mCi) and a PTS. A total of 117 PTS were evaluated. At the time of PTS, clinical or radiologic evidence of metastatic or residual disease was present in 68 patients (84%). The anatomic sites of known disease included, neck (63), mediastinum (23), lung (35), bone (14), trachea (16), esophagus (5), and brain (2). PTS showed focal areas of abnormal uptake not seen in diagnostic scans in 15 scans (13%). Areas with abnormal new uptake included: neck (5), lung (5), mediastinum (4), bone (2), and adrenal (1). In 7 patients (9%) the PTS results impacted future decisions regarding plans for subsequent diagnostic scanning and 131I therapy or changed the patient's risk group category. IN CONCLUSION (1) 13% of 117 PTS demonstrated abnormal foci of 131I uptake not seen on pretherapy scans and (2) PTS changed management strategy in 9% of the studied patients.
Functional and Molecular Surveillance of Helicobacter pylori Antibiotic Resistance in Kuala Lumpur

Background Helicobacter pylori is the etiological agent for diseases ranging from chronic gastritis and peptic ulcer disease to gastric adenocarcinoma and primary gastric B-cell lymphoma. Emergence of resistance to antibiotics possesses a challenge to the effort to eradicate H. pylori using conventional antibiotic-based therapies. The molecular mechanisms that contribute to the resistance of these strains have yet to be identified and are important for understanding the evolutional pattern and selective pressure imposed by the environment. Methods and Findings H. pylori was isolated from 102 patients diagnosed with gastrointestinal diseases, who underwent endoscopy at University Malaya Medical Centre (UMMC). The isolates were tested for their susceptibility on eleven antibiotics using Etest. Based on susceptibility test, 32.3% of the isolates were found to have primary metronidazole resistance; followed by clarithromycin (6.8%) and fluoroquinolones (6.8%). To further investigate the resistant strains, mutational patterns of gene rdxA, frxA, gyrA, gyrB, and 23S rRNA were studied. Consistent with the previous reports, metronidazole resistance was prevalent in the local population. However, clarithromycin, fluoroquinolone and multi-drug resistance were shown to be emerging. Molecular patterns correlated well with phenotypic data. Interestingly, multi-drug resistant (MDR) strains were found to be associated with higher minimum inhibitory concentration (MIC) than their single-drug resistant (SDR) counterparts. Most importantly, clarithromycin-resistant strains were suggested to have a higher incidence for developing multi-drug resistance. Conclusion Data from this study highlighted the urgency to monitor closely the prevalence of antibiotic resistance in the Malaysian population; especially that of clarithromycin and multi-drug resistance. Further study is needed to understand the molecular association between clarithromycin resistance and multi-drug resistance in H. pylori. The report serves a reminder that a strict antibiotic usage policy is needed in Malaysia and other developing countries (especially those where H. pylori prevalence remained high).
Association of airflow limitation with trauma exposure and post-traumatic stress disorder

Trauma exposure and post-traumatic stress disorder (PTSD) are associated with self-reported asthma and chronic obstructive pulmonary disease. However, these conditions have not yet been related to objective measures of lung function. 1,772 adults from the general population were assessed regarding their medical histories and spirometric lung function. Additionally, they were administered a PTSD interview, and assigned to three groups: no trauma; trauma, but no PTSD; and trauma with PTSD. Adjusting for sociodemographic, clinical and lifestyle factors, subjects with PTSD had significantly higher odds ratios for most asthma-related symptoms than PTSD-negative participants (OR 3.2–8.8). The mean ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) was lowest in the PTSD group and highest in those without trauma exposure. Traumatic stress was independently associated with FEV1 and FEV1/FVC. Participants with PTSD, compared with those without, had a significantly increased risk for airflow limitation independent of its definition (OR 4.2–7.8). This is the first study relating traumatic stress and PTSD, respectively, to objective parameters of lung function. Our findings suggest an association of trauma exposure and PTSD with airflow limitation, which may be mediated by inflammatory processes.
Navigating high-dimensional spaces to support design steering

Throughout the design cycle, visualization, whether a sketch scribbled on the back of a spare piece of paper or a fully detailed drawing, has been the mainstay of design: we need to see the product. One of the most important stages of the design cycle is the initial, or concept, stage and it is here that design variants occur in large numbers to be vetted quickly. At this initial stage the human element, the designer is crucial to the success of the product. We describe an interactive environment for concept design which recognises the needs of the designer, not only to see the product and make rapid modifications, but also to monitor the progress of their design towards some preferred solution. This leads to the notion of a design parameter space, typically high-dimensional, which must also be visualized in addition to the product itself. Using a module developed for IRIS Explorer design steering is presented as a navigation of this space in order to search for optimal designs, either manually or by local optimisation.
Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults

Although fatty acid binding protein 4 (FABP4) may increase risk of diabetes and exert negative cardiac inotropy, it is unknown whether plasma concentrations of FABP4 are associated with incidence of sudden cardiac death (SCD). We prospectively analyzed data on 4,560 participants of the Cardiovascular Health Study. FABP4 was measured at baseline using ELISA, and SCD events were adjudicated through review of medical records. We used Cox proportional hazards to estimate effect measures. During a median followup of 11.8 years, 146 SCD cases occurred. In a multivariable model adjusting for demographic, lifestyle, and metabolic factors, relative risk of SCD associated with each higher standard deviation (SD) of plasma FABP4 was 1.15 (95% CI: 0.95–1.38), P = 0.15. In a secondary analysis stratified by prevalent diabetes status, FABP4 was associated with higher risk of SCD in nondiabetic participants, (RR per SD higher FABP4: 1.33 (95% CI: 1.07–1.65), P = 0.009) but not in diabetic participants (RR per SD higher FABP4: 0.88 (95% CI: 0.62–1.27), P = 0.50), P for diabetes-FABP4 interaction 0.049. In summary, a single measure of plasma FABP4 obtained later in life was not associated with the risk of SCD in older adults overall. Confirmation of our post-hoc results in nondiabetic people in other studies is warranted.
Optimal Detector for Multitaper Spectrum Estimator in Cognitive Radios

In this paper, the authors propose an optimal detector for the Thomson's multitaper spectral estimation (MTSE) in cognitive radios for spectrum sensing. The MTSE is used for spectral estimation and then the proposed detector can detect primary users and spectrum holes in cognitive radios. The detector is optimized based on the Neyman-Pearson Theorem. The analytical detection performance (probability of detection) of detecting primary users (PUs) and spectrum holes in spectrum sensing is mathematically formulated and verified by simulations. The proposed detector for the MTSE is non-cooperative in spectrum sensing and can perform blind spectrum sensing without prior knowledge of the primary users. Compared to the conventional energy detector, the proposed detector is more reliable and robust for various multiple Slepian tapers. The proposed detector outperforms the cooperative autocorrelation-based detectors in detection rate by 48% and with 3dB gain in SNR performance. Moreover, the minimum required observation size is smaller than the conventional energy detector by a reduction of 73.3%.
Effects of Balance Training on Postural Sway, Leg Extensor Strength, and Jumping Height in Adolescents

Deficits in strength of the lower extremities and postural control have been associated with a high risk of sustaining sport-related injuries. Such injuries often occur during physical education (PE) classes and mostly affect the lower extremities. Thus, the objectives of this study were to investigate the effects of balance training on postural sway, leg extensor strength, and jumping height in adolescents. Twenty high school students participated in this study and were assigned to either an intervention (n = 10) or control group (n = 10). The intervention group participated in a 4-week balance-training program integrated in their physical education lessons. Pre- and posttests included the measurements of postural sway on a balance platform, jumping height on a force platform, and maximal isometric leg extension force on a leg-press. Balance training resulted in significantly improved postural control, increased jumping height, and enhanced rate of force development of the leg extensors. Physiological adaptations rather than learning effects seem to be responsible for the observed findings. These results could have an impact on improving the performance level in various sports and on reducing the injury prevalence of the lower extremities.