Miracle-dz/UniFAR-FTUs huggingface dataset:
Autoimmunity and Pregnancy Loss

Autoimmunity affects women more commonly than men. It usually first appears in the reproductive years and thus may complicate pregnancy. In a few clinical autoimmune conditions, such as systemic lupus erythematosus, affected patients have an increased rate of pregnancy loss. In other conditions, pregnancy loss may be the only expression of autoimmunity. The condition of autoimmunity exists along a spectrum ranging from a subclinical autoimmune "diathesis' to frank autoimmune disease. Frank autoimmune disease usually presents as a combination of clinical signs and symptoms and relevant autoantibodies. In many but not all diseases, direct or circumstantial evidence links the presence of a specific autoantibody to a specific feature of the clinical disease (e.g., thyroid-stimulating antibodies and hyperthyroidism). The common autoimmune diseases usually have a typical pattern of clinical features and autoantibodies. This has allowed the development of diagnostic criteria for establishing a specific autoimmune diagnosis. In turn, these criteria have helped immensely in the study of the relevant clinical associations (including pregnancy loss), appropriate therapy, and the course of disease. It is important to recognize that autoimmunity is not confined to the clinically obvious. A small proportion of "normal" individuals have circulating autoantibodies. These asymptomatic individuals are generally considered to have a subclinical autoimmune "diathesis," the long-term implications of which are currently unknown. It has recently become apparent that some of these women have recurrent pregnancy loss or fetal death as the only manifestation of their autoimmune condition. Investigators have considered several autoantibodies as being possibly relevant, but the antiphospholipid antibodies have been the most strongly implicated. The emphasis of this review will be on the association between autoimmunity, both clinical and subclinical, and pregnancy loss. Because they are not generally considered a cause of recurrent pregnancy loss, autoimmune thrombocytopenia and autoimmune diseases of the thyroid are not included in this review. They have been recently covered elsewhere. -
Drifting runoff periodicity during the 20th century due to changing surface water volume

Fourier and wavelet analyses were used to reveal the dominant trends and coherence of a more than one‐century‐long time series of precipitation and discharge in several watersheds in Sweden, two of which were subjected to hydropower and intensive agriculture. During the 20th century, there was a gradual, significant drift of the dominant discharge periodicity in agricultural watersheds. This study shows that the steepness of the Fourier spectrum of runoff from the May to October period each year increased gradually during the century, which suggests a more predictable intra‐annual runoff pattern (more apart from white‐noise). In the agricultural watershed, the coherence spectrum of precipitation and runoff is generally high with a consistent white‐noise relationship for precipitation during the 20th century, indicating that precipitation is not controlling the drift of the discharge spectrum. In the hydropower regulated watershed, there was a sudden decrease of the discharge spectrum slope when regulation commenced in the 1920s. This study develops a new theory in which the runoff spectrum is related to the hydraulic and hydro‐morphological characteristics of the watershed. Using this theory, we explain the changes in runoff spectra in the two watersheds by the anthropogenic change in surface water volume and, hence, changes in kinematic wave celerity and water transit times. The reduced water volume in the agricultural watershed would also contribute to decreasing evaporation, which could explain a slightly increasing mean discharge during the 20th century despite the fact that precipitation was statistically constant in the area. Copyright © 2010 John Wiley & Sons, Ltd.
The impact of cognitive load on the perception of time

In cognitive psychology it is well known that cognitive load can have a significant impact on time perception. In this paper, we present an observation made during an empirical evaluation of several input techniques, showing that the cognitive load occurring during user input can significantly reduce perceived time. We provide a discussion of our findings, proposing that existing work in cognitive psychology, such as the Cognitive-Timer Model is applicable to HCI; and that this understanding can provide valuable information for predicting and actively modeling perceived input performance when designing user interfaces.
Illness awareness of patients in hospice: psychological evaluation and perception of family members and medical staff.

BACKGROUND Despite the widespread belief that patients should be given full information about their disease and prognosis, they actually they know very little. The purpose of this study was to evaluate the awareness of 100 patients (from the Hospices of Rimini and Savignano-Rubicone) about their diagnoses and prognoses. It is also investigated staff and relatives perceptions of patients' awareness. METHODS A semistructured interview of patients was performed by psychologists to evaluate their awareness about diagnosis and prognosis. Then psychologists completed a questionnaire about their own evaluation of patients' disease awareness. Moreover, the same questionnaire was completed by family members and by staff members (doctors and nurses) about their perceptions of patients' awareness. Doctors and nurses gave their answers based on their routine interactions with patients. RESULTS Despite the fact that patients in hospice were in the terminal phase of disease, 30% of patients had no diagnosis awareness, and an even higher percentage of patients (62%) who had no prognosis awareness.
Grape seed proanthocyanidin extract improves the hepatic glutathione metabolism in obese Zucker rats.

SCOPE Increased oxidative stress may play an important role in metabolic syndrome and related manifestations, including obesity, atherosclerosis, hypertension, and insulin resistance. Its relation to obesity is due to increased reactive oxygen species and/or decreased glutathione (GSH) antioxidant metabolism. Consequently, the activation of glutathione metabolism appears to be a central defense response to prevent oxidative stress. In this sense, dietary supplements with natural antioxidant molecules, including proanthocyanidins, may present a useful strategy of controlling and reducing complications of obesity, including hepatic steatosis. MATERIALS AND RESULTS We assessed the grape seed proanthocyanidin extract (GSPE) effect on oxidative alterations related to genetically obese rats (Zucker rats) and, more specifically, to hepatic GSH metabolism. We demonstrate that the administration of GSPE reduced the oxidized glutathione accumulation increasing the total GSH/oxidized glutathione hepatic ratio and consequently decreasing the activation of antioxidant enzymes, including glutathione peroxidase, glutathione reductase, and glutathione S-transferase, and increasing the total antioxidant capacity of the cell. CONCLUSION In Zucker rats, the obesity-induced oxidative stress related to liver glutathione alteration was mitigated by GSPE administration.
Effects and Mechanism of Blue Light on Monascus in Liquid Fermentation

The effect of light on Monascus and the underlying mechanism have received a great deal of interest for the industrial application of Monascus pigments. In this study, we have examined the effects of blue light on the culture morphology, mycelium growth, pigments, and citrinin yield of Monascus in liquid-state and oscillation fermentation, and explored the mechanism at a physiological level. It was found that blue light affected the colony morphology, the composition (chitin content), and permeability of the Monascus mycelium cell wall in static liquid culture, which indicates blue light benefits pigments secreting from aerial mycelium to culture medium. In liquid oscillation fermentation, the yields of Monascus pigments in fermentation broth (darkness 1741 U/g, blue light 2206 U/g) and mycelium (darkness 2442 U/g, blue light 1900 U/g) cultured under blue light and darkness are different. The total pigments produced per gram of Monascus mycelium under blue light was also higher (4663 U/g) than that in darkness (4352 U/g). However, the production of citrinin (88 μg/g) under blue light was evidently lower than that in darkness (150 μg/g). According to the degradation of citrinin caused by blue light and hydrogen peroxide, it can be concluded that blue light could degrade citrinin and inhibit the catalase activity of Monascus mycelium, subsequently suppressing the decomposition of hydrogen peroxide, which is the active species that degrades citrinin.
Bearing capacity of foundations on slopes

By applying the lower bound finite element limit analysis in conjunction with non-linear optimisation, the bearing capacity factors, Nc, Nq and Nγ, due to the components of cohesion, surcharge and unit weight, respectively, have been estimated for a horizontal strip footing placed along a sloping ground surface. The variation of Nc, Nq and Nγ with changes in slope angle (β) for different soil friction angle (φ) have been computed for smooth as well as rough strip footings. The analysis reveals that along a sloping ground surface, in addition to Nγ, the factors Nc and Nq also vary considerably with changes in footing roughness. Compared to the smooth footing, the extent of the plastic zone around the footing becomes greater for the rough footing. The results obtained from the analysis are found to compare well with those previously reported in literature.
Computing Declarative Prosodic Morphology

This paper describes a computational, declarative approach to prosodic morphology that uses inviolable constraints to denote small finite candidate sets which are filtered by a restrictive incremental optimization mechanism. The new approach is illustrated with an implemented fragment of Modern Hebrew verbs couched in MicroCUF, an expressive constraint logic formalism. For generation and parsing of word forms, I propose a novel off-line technique to eliminate run-time optimization. It produces a finitestate oracle that efficiently restricts the constraint interpreter's search space. As a byproduct, unknown words can be analyzed without special mechanisms. Unlike pure finite-state transducer approaches, this hybrid setup allows for more expressivity in constraints to specify e.g. token identity for reduplication or arithmetic constraints for phonetics.
An Examination of Emotional Intelligence as a Potential Mediator in Educator Stress and Burnout

The objective of this study was to investigate the relationship between teacher burnout, emotional intelligence, attitudes towards seeking professional help, and perceptions of psychological safety within schools. Findings from this study of 600 Canadian educational professionals suggest that emotional intelligence and perceptions of psychological safety were significant predictors of teacher burnout, while attitudes towards seeking professional help were not. Teaching level, employment status (e.g., part-time versus full-time), and gender were also explored in relation to burnout. Findings suggested that full-time status significantly impacted levels of burnout, while teaching level and gender did not. The potential preventative impact of interventions focusing on emotional intelligence and psychological workplace safety was discussed. Recommendations for future research were suggested.
A parameterization of the wavelength of tidal dunes

The idealized model of Besio et al. (On the formation of sand waves and sand banks. Journal of Fluid Mechanics 2006; 557: 1–17) is used to predict the wavelength of tidal dunes (sand waves) generated by tidal currents in estuaries and shallow seas. The predictions are then analysed and a formula is proposed to estimate the wavelength of tidal dunes as a function of the parameters of the problem. The wavelength of the dunes is found to increase when the water depth is increased and/or the strength of the tidal current is decreased. On the other hand, the size of the bottom material (if medium sand is considered) and the tidal ellipticity are found to have a relatively small influence on the length of the bottom forms. The formula proposed provides results which are consistent with field observations of different authors. Copyright © 2011 John Wiley & Sons, Ltd.
Location Coding by Opponent Neural Populations in the Auditory Cortex

Although the auditory cortex plays a necessary role in sound localization, physiological investigations in the cortex reveal inhomogeneous sampling of auditory space that is difficult to reconcile with localization behavior under the assumption of local spatial coding. Most neurons respond maximally to sounds located far to the left or right side, with few neurons tuned to the frontal midline. Paradoxically, psychophysical studies show optimal spatial acuity across the frontal midline. In this paper, we revisit the problem of inhomogeneous spatial sampling in three fields of cat auditory cortex. In each field, we confirm that neural responses tend to be greatest for lateral positions, but show the greatest modulation for near-midline source locations. Moreover, identification of source locations based on cortical responses shows sharp discrimination of left from right but relatively inaccurate discrimination of locations within each half of space. Motivated by these findings, we explore an opponent-process theory in which sound-source locations are represented by differences in the activity of two broadly tuned channels formed by contra- and ipsilaterally preferring neurons. Finally, we demonstrate a simple model, based on spike-count differences across cortical populations, that provides bias-free, level-invariant localization—and thus also a solution to the “binding problem” of associating spatial information with other nonspatial attributes of sounds.
Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment

Pluripotent cells develop within the inner cell mass of blastocysts, a mosaic of cells surrounded by an extra-embryonic layer, the trophectoderm. We show that a set of somatic lineage regulators (including Hox, Gata and Sox factors) that carry bivalent chromatin enriched in H3K27me3 and H3K4me2 are selectively targeted by Suv39h1-mediated H3K9me3 and de novo DNA methylation in extra-embryonic versus embryonic (pluripotent) lineages, as assessed both in blastocyst-derived stem cells and in vivo. This stably repressed state is linked with a loss of gene priming for transcription through the exclusion of PRC1 (Ring1B) and RNA polymerase II complexes at bivalent, lineage-inappropriate genes upon trophoblast lineage commitment. Collectively, our results suggest a mutually exclusive role for Ring1B and Suv39h1 in regulating distinct chromatin states at key developmental genes and propose a novel mechanism by which lineage specification can be reinforced during early development.
Factors influencing students to enroll in health information management programs.

This nonexperimental quantitative descriptive-correlative research study was performed to describe the sources with the greatest influence on the participants' decision to enroll in a postsecondary educational program with the intent of working toward a career in health information management. Participants were asked, "Which sources have the greatest influence on an individual's decision to enroll in a postsecondary educational program with the intent of working toward a career in health information management (HIM)? " The study population was composed of matriculated students enrolled in accredited postsecondary schools offering an undergraduate medical billing and coding program at a brick-and-mortar campus in a two-county area of a South Atlantic state. The study found that an environmental source, specifically career job opportunities, was statistically significant as the greatest source of influence for these participants. This research aims to support efforts to provide the health information management subsector of the healthcare industry with a sufficient number of trained professionals to fill the identified need for trained HIM professionals, particularly medical coding specialists.
Multiple cells express interleukin 17 in oral squamous cell carcinoma

BACKGROUND Interleukin (IL)-17 is a pro-inflammatory cytokine with pro- and antitumour effects. The aim of this study was to investigate the presence and potential sources of IL-17 in oral squamous cell carcinoma (OSCC). METHODS Immunohistochemistry was used to label and compare IL-17+ cells in the tissue sections of OSCC and inflammatory controls (IC), n = 14 for both. In OSCC, the comparison was made between the number of IL-17+ cells in the tumoral islands (TI), tumour-stroma interface (TS) and more distant stroma (DS). Cells expressing IL-17 were identified using double-labelling immunofluorescence and examined using laser scanning microscopy. The production of IL-17 from tumour cells was determined in the culture supernatants of OSCC cell lines, SCC4, SCC15 and SCC25, using sandwich ELISA. RESULTS Significantly more IL-17+ cells were observed in OSCC compared with IC (Mann-Whitney, P < 0.0001). In OSCC, the numbers of IL-17+ cells were not significantly different in three compartments, TI, TS and DS (one-way ANOVA, P > 0.05). However, the TI had significantly fewer IL-17+ cells than the combined stroma (both TS and DS together, Mann-Whitney, P < 0.01). Laser scanning microscopy revealed helper T cells, cytotoxic T cells, macrophages and mast cells co-expressed IL-17. ELISA experiments did not detect IL-17 in the supernatants of OSCC cell lines. CONCLUSIONS Although the tumour cells themselves did not express IL-17, a range of cell types did, suggesting multiple cellular sources for IL-17 in OSCC. The spatial distribution of IL-17+ cells suggests specific interactions with cells within the tumour microenvironment, implying that IL-17+ cells are likely to play a role in the pathogenesis of OSCC.
Current scenario of attitude and knowledge of physicians about rational prescription: A novel cross-sectional study

Background: In the last 30 years concepts in pharmacology have moved from Essential Medicines (EM) to P-drugs via the Rational Use of Medicines (RUM), but no structured study has evaluated the level of understanding among the working clinicians about these concepts. Aim: The present study was designed to assess the attitude and knowledge of clinical practitioners about the concepts of RUM, EM, P-drugs, and sources of drug-information, across North India. Materials and Methods: A cross-sectional study was carried out in and around the teaching hospitals attached to Medical Colleges, enrolling 504 clinicians from six centers across North India to fill-up a questionnaire containing 25 questions. Statistical Analysis: The results were compiled using percentages and averages. Univariate analysis, which explores each variable in a data set separately, was carried out by using the Fisher's exact test. Results: Only one-fourth of the participants claimed that they always prescribed Essential Medicine; no one could correctly count the number of drugs / drug combinations in the Indian Essential Drug list; only 15.1% of the clinicians wrote the generic names of drugs on the prescription slip; about one-third of clinicians were not fully aware about the adverse effects, drug interactions, and contraindications of the drugs they prescribed; about 83% of physicians admitted to relying on information from Medical Representatives and an interest in research activities seemed to be lost. Conclusion: Results show a sorry state of affairs among clinicians, as far as the level of understanding about EM, P-drugs, and RUM is concerned, and it points toward arranging more continuing medical education (CME) for clinicians with regard to these concepts.
Noncanonical notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of trio

The receptor Notch interacts with the Abl tyrosine kinase signaling pathway to control axon growth and guidance in Drosophila motor neurons. In part, this is mediated by binding to Trio, a guanine nucleotide exchange factor (GEF) for Rho GTPases. We show here that one of the two GEF domains of Trio, the Rac‐specific GEF1, is essential for Trio‐dependent motor axon guidance and for the genetic suppression of Notch function in motor axon patterning, but the Rho‐specific GEF2 domain is not. Consistent with this, we show that Rac, and not Rho1 or Cdc42, interacts genetically with Notch in a manner indistinguishable from that of bona fide Abl signaling components. We infer, therefore, that Rac is a key component of Abl signaling in Drosophila motor axons, and specifically that it is the crucial Rho GTPase in “noncanonical” Notch/Abl signaling. Developmental Dynamics 240:324–332, 2011. © 2011 Wiley‐Liss, Inc.
Methods to determine the impact of rainfall on fuels and burned area in southern African savannas

In southern African savannas, grass production, and therefore the annual extent of fire, is highly dependent on rainfall. This response has repeatedly been noted in the literature but authors used different input variables and modelling approaches and the results are not comparable. Using long-term fire occurrence data from six protected areas in southern Africa we tested various methods for determining the relationship between antecedent rainfall and burned area. The types of regression model, the most appropriate index of accumulated rainfall, and the period over which to calculate annual burned area were all investigated. The importance of accumulating rainfall over more than one growing season was verified in all parks – improving the accuracy of the models by up to 30% compared with indices that only used the previous year’s rainfall. Up to 56% of the variance in burned area between years could be explained by an 18-month accumulated rainfall index. Linear models and probit models performed equally well. The method suggested in this paper can be applied across southern Africa. This will improve our understanding of the drivers of interannual variation in burned area in this globally important fire region.
Production of monoclonal antibodies to human estrogen‐receptor protein (ER) using recombinant ER (RER)

Two monoclonal antibodies (MAbs), IC5 and ID5, were produced using spleen cells from BALB/c mice immunized with recombinant estrogen‐receptor protein (RER). On immunoblotting, both MAbs reacted with the 67‐kDa polypeptide chain obtained by transformation of E. coli and transaction of COS cells with plasmid vectors expressing ER. The epitopes of both MAbs were in the N‐terminal domain (A/B region) of the receptor. In normal human tissues, IC5 and ID5 reacted with cells known to contain large amount of ER, such as cells of the mammary gland and the uterus. Staining was localized predominantly in nuclei with little or no cytoplasmic reactivity. IC5 and ID5 were unreactive with tissues usually considered to be negative for ER. The reactions of these 2 MAbs were further tested on different tumor types, using immunohistochemical (IHC) method on frozen sections. In breast cancer, a good correlation was found between the results obtained on frozen sections and those using the conventional radioligand dextran‐coated charcoal (DCC) assay. Immunostaining with IC5 and ID5 MAbs was also assessed on routinely processed paraffin sections using the antigen‐retrieval method. Staining was comparable to that obtained on frozen sections in virtually all the breast carcinomas. Negative reactions were consistently obtained with both antibodies on human neoplasms derived from other non‐estrogen‐dependent organs. IC5 and ID5 MAbs may thus be of value in routine diagnostic histopathology for assessment of the estrogen‐receptor content in human carcinomas.