Miracle-dz/UniFAR-FTUs huggingface dataset:
Forced G1-phase reduction alters mode of division, neuron number, and laminar phenotype in the cerebral cortex

The link between cortical precursors G1 duration (TG1) and their mode of division remains a major unresolved issue of potential importance for regulating corticogenesis. Here, we induced a 25% reduction in TG1 in mouse cortical precursors via forced expression of cyclin D1 and cyclin E1. We found that in utero electroporation-mediated gene transfer transfects a cohort of synchronously cycling precursors, necessitating alternative methods of measuring cell-cycle phases to those classical used. TG1 reduction promotes cell-cycle reentry at the expense of differentiation and increases the self-renewal capacities of Pax6 precursors as well as of Tbr2 basal precursors (BPs). A population level analysis reveals sequential and lineage-specific effects, showing that TG1 reduction: (i) promotes Pax6 self-renewing proliferative divisions before promoting divisions wherein Pax6 precursors generate Tbr2 BPs and (ii) promotes self-renewing proliferative divisions of Tbr2 precursors at the expense of neurogenesis, thus leading to an amplification of the BPs pool in the subventricular zone and the dispersed mitotic compartment of the intermediate zone. These results point to the G1 mode of division relationship as an essential control mechanism of corticogenesis. This is further supported by long-term studies showing that TG1 reduction results in cytoarchitectural modifications including supernumerary supragranular neuron production. Modeling confirms that the TG1-induced changes in neuron production and laminar fate are mediated via the changes in the mode of division. These findings also have implications for understanding the mechanisms that have contributed to brain enlargement and complexity during evolution.
Convolutional Models for Joint Object Categorization and Pose Estimation

In the task of Object Recognition, there exists a dichotomy between the categorization of objects and estimating object pose, where the former necessitates a view-invariant representation, while the latter requires a representation capable of capturing pose information over different categories of objects. With the rise of deep architectures, the prime focus has been on object category recognition. Deep learning methods have achieved wide success in this task. In contrast, object pose regression using these approaches has received relatively much less attention. In this paper we show how deep architectures, specifically Convolutional Neural Networks (CNN), can be adapted to the task of simultaneous categorization and pose estimation of objects. We investigate and analyze the layers of various CNN models and extensively compare between them with the goal of discovering how the layers of distributed representations of CNNs represent object pose information and how this contradicts with object category representations. We extensively experiment on two recent large and challenging multi-view datasets. Our models achieve better than state-of-the-art performance on both datasets.
Patterns of Traditional Chinese Medicine Diagnosis in Thermal Laser Acupuncture Treatment of Knee Osteoarthritis

Knee osteoarthritis (OA) manifests with pain, joint stiffness, and limited function. In traditional Chinese medicine, knee OA is differentiated into three patterns: yang deficiency and cold coagulation, kidney deficiency, and blood stasis. The objective of this study was to determine whether yang deficiency cold coagulation patients respond better to thermal laser acupuncture treatment than do non-yang deficient patients. Fifty-two patients with OA were allocated to group A (yang deficient, n = 26) or B (non-yang deficient, n = 26). All patients received a 20-min thermal laser acupuncture treatment at acupoint Dubi (ST 35) three times a week for two weeks and twice a week for another four weeks. Outcome assessments were performed immediately after the first treatment, and at weeks 2, 6, and 10. Group A function scores were significantly better than those of Group B at weeks 2 (P = 0.049), 6 (P = 0.046), and 10 (P = 0.042), but no significant differences were found between the two groups in pain and stiffness scores at any time point. No significant adverse effect was observed. The combined 10.6 μm–650 nm laser treatment might be most beneficial to yang deficiency cold coagulation knee OA patients, particularly in improving function.
Lucky Imaging of M subdwarfs

Context. The knowledge of the binary properties of metal-poor and solar-metallicity stars can shed light on the potential differences between the formation processes responsible for both types of objects. Aims. The aim of the project is to determine the binary properties (separation, mass ratio, frequency of companions) for M subdwarfs, the low-metallicity counterparts of field M dwarfs, and investigate any potential differences between both populations. Methods. We have obtained high-resolution imaging in the optical for a sample of 24 early-M subdwarfs and nine extreme subdwarfs with the “Lucky Imaging” technique using the AstraLux instrument on the Calar Alto 2.2-m telescope. Results. We are sensitive to companions at separations larger than 0.1 arcsec and differences of ∼2 mag at 0.1 arcsec and ∼5 mag at 1 arcsec. We have found no companion around the 24 subdwarfs under study and one close binary out of nine extreme subdwarfs. A second image of LHS 182 taken three months later with the same instrument confirms the common proper motion of the binary separated by about 0.7 arcsec. Moreover, we do not confirm the common proper motion of the faint source reported by Riaz and collaborators at ∼2 arcsec from LHS 1074. Conclusions. We derive a binary frequency of 3 ± 3% for M subdwarfs from our sample of 33 objects for separations larger than about five astronomical units. Adding to our sample the additional 28 metal-poor early-M dwarfs observed with the Hubble Space Telescope by Riaz and collaborators, we infer a binary fraction of 3.7 ± 2.6% (with a 1σ confidence limit), significantly lower than the fraction of resolved binary M dwarfs (∼20%) over the same mass and separation ranges. This result suggests a sharp cut-off in the multiplicity fraction from G to M subdwarfs, indicating that the metallicity plays a role at lower masses and/or an environmental effect governing the formation of metal-poor M dwarfs compared to their metallicity counterparts.
Pro-cathepsin D interacts with the extracellular domain of the β chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth

Interactions between cancer cells and fibroblasts are crucial in cancer progression. We have previously shown that the aspartic protease cathepsin D (cath-D), a marker of poor prognosis in breast cancer that is overexpressed and highly secreted by breast cancer cells, triggers mouse embryonic fibroblast outgrowth via a paracrine loop. Here, we show the requirement of secreted cath-D for human mammary fibroblast outgrowth using a three-dimensional co-culture assay with breast cancer cells that do or do not secrete pro-cath-D. Interestingly, proteolytically-inactive pro-cath-D remains mitogenic, indicating a mechanism involving protein-protein interaction. We identify the low-density lipoprotein (LDL) receptor-related protein-1, LRP1, as a novel binding partner for pro-cath-D in fibroblasts. Pro-cath-D binds to residues 349–394 of the β chain of LRP1, and is the first ligand of the extracellular domain of LRP1β to be identified. We show that pro-cath-D interacts with LRP1β in cellulo. Interaction occurs at the cell surface, and overexpressed LRP1β directs pro-cath-D to the lipid rafts. Our results reveal that the ability of secreted pro-cath-D to promote human mammary fibroblast outgrowth depends on LRP1 expression, suggesting that pro-cath-D–LRP1β interaction plays a functional role in the outgrowth of fibroblasts. Overall, our findings strongly suggest that pro-cath-D secreted by epithelial cancer cells promotes fibroblast outgrowth in a paracrine LRP1-dependent manner in the breast tumor microenvironment.
Bendamustine plus rituximab is an effective first-line treatment in hairy cell leukemia variant: a report of three cases

Hairy cell leukemia variant (HCLv) is a chronic lymphoproliferative disorder classified as a provisional entity in the 2016 WHO Classification of Lymphoid Tumors. HCLv is characterized by unfavorable prognosis, low complete remission rates and limited disease control following classical hairy cell leukemia-based regimens. In this study, we report 3 cases of elderly patients with treatment-naive, TP53 un-mutated HCLv, who were effectively treated with four cycles of bendamustine plus rituximab. The regimen was completed in all the patients with acceptable toxicity. All patients achieved a complete clinical response with no evidence of residual disease at bone marrow biopsy and flow-cytometry examination. After a median follow-up of 19 months, the 3 subjects are still in complete remission. In this work, bendamustine plus rituximab proved to be an effective and feasible first-line treatment strategy for elderly patients with TP53 un-mutated HCLv.
TRT - A Tripleset Recommendation Tool

According to the Linked Data principles, a tripleset should be interlinked with others to take advantage of existing knowledge. However, interlinking is a laborious task. Thus, users interlink their triplesets mostly with data hubs, such as DBpedia and Freebase, ignoring the more specific yet often even more promising triplesets. To alleviate this problem, this paper describes a tripleset interlinking recommendation tool based on link prediction techniques and evaluates the tool on a real-world tripleset repository.
Newborn Boys and Girls Differ in the Lipid Composition of Vernix Caseosa

Vernix caseosa protects the skin of a human fetus during the last trimester of pregnancy and of a newborn after the delivery. Besides its cellular and proteinaceous components, an important constituent and functional agent is a complex lipid fraction, implicated in a multitude of salubrious effects of vernix caseosa. Little is known about how the chemical composition of vernix caseosa lipids is affected by various biological characteristics of the baby, such as the gestational age, birth weight, and, last but not least, the gender of the newborn. This study reports on the chemical variability of lipids contained in the vernix caseosa of twenty newborn girls and boys and shows that the quantitative patterns of the lipids are sex-specific. The specificity of lipids was investigated at the level of fatty acids in the total lipid extracts and intact lipids of several neutral lipid classes. Hydrocarbons, wax esters, cholesteryl esters, diol diesters and triacylglycerols were isolated using optimized semipreparative thin-layer chromatography, and the molecular species within each class were characterized using matrix-assisted laser desorption/ionization mass spectrometry. Statistical evaluation revealed significant quantitative sex-related differences in the lipid composition of vernix caseosa among the newborns, pronounced in the two lipid classes associated with the activity of sebaceous glands. Higher proportions of wax esters and triacylglycerols with longer hydrocarbon chains were observed in newborn girls.
Optimal Control of a Mechanical Hybrid Powertrain With Cold-Start Conditions

This paper investigates the impact of cold-start conditions on the fuel-saving potential and the associated optimal energy controller of a mechanical hybrid powertrain. The mechanical hybrid powertrain uses a flywheel system to add fuel-saving functionalities to a conventional powertrain, which consists of an internal combustion engine and a continuously variable transmission (CVT). The cold-start conditions refer to a low powertrain temperature, which increases the frictional power dissipation in the engine and transmission, and a stationary (or energyless) flywheel system, which must be energized to a minimum energy level before it can be effectively utilized. The heating of the powertrain and the initialization of the flywheel system can be influenced by the energy controller, which controls the power distribution between the engine, the flywheel, and the vehicle. The energy controller aims at minimizing the overall fuel consumption for a given driving cycle. The optimal energy controller is found analytically for a simplified model to gain qualitative insights in the controller and numerically using dynamic programming for a detailed model to quantify the impact on the fuel consumption. The results show that the cold-start conditions have a significant impact on the fuel-saving potential, yet a negligible impact on the optimal energy controller. The latter result implies that the temperature state can be eliminated from the state space of the energy controller, which is an important step toward the design of an effective yet simple energy controller suitable for real-time implementation.
Limbal stem cells may be depleted by a wide range of pathological Culture & characterisation of limbal epithelial cells & oral mucosal cells

increasingly implicated as a cause of ocular surface diseases including pterygium. Limbal stem cells act as a physiological barrier to the ingress of conjunctival cells across the cornea1. Deficiency leads to conjunctivalisation of the cornea, surface irregularity, and vascularisation. Limbal stem cells may be depleted by a wide range of pathological Culture & characterisation of limbal epithelial cells & oral mucosal cells
A New gauge mediation theory

We propose a class of models with gauge mediation of supersymmetry breaking, inspired by simple brane constructions, where R-symmetry is very weakly broken. The gauge sector has an extended N = 2 supersymmetry and the two electroweak Higgses form an N = 2 hypermultiplet, while quarks and leptons remain in N = 1 chiral multiplets. Supersymmetry is broken via the D-term expectation value of a secluded U(1) and it is transmitted to the Standard Model via gauge interactions of messengers in N = 2 hypermultiplets: gauginos thus receive Dirac masses. The model has several distinct experimental signatures with respect to ordinary models of gauge or gravity mediation realizations of the Minimal Supersymmetric Standard Model (MSSM). First, it predicts extra states as a third chargino that can be observed at collider experiments. Second, the absence of a D-flat direction in the Higgs sector implies a lightest Higgs behaving exactly as the Standard Model one and thus a reduction of the ‘little’ fine-tuning in the low tan β region. This breaking of supersymmetry can be easily implemented in string theory models.
Configurable Thru-Silicon-Via interconnect Built-In Self-Test and diagnosis

Three-dimensional integration is a key technology for systems whose performance / power requirements cannot be achieved by traditional silicon technologies. Testing is one of the major challenges of 3D integration. This paper proposes a configurable Interconnect Built-In Self-Test (BIST) technique for inter-die interconnects (Thru-Silicon Vias TSVs). The proposed technique accounts for faults like opens and shorts and also delay faults due to crosstalk. In the proposed fault model, the signal transitions on victim TSVs are affected by the transitions on the aggressor TSVs. The Kth Aggressor Fault model (KAF) assumes that the aggressors of each victim TSV are the K-order neighbors. The test times are reduced as more victim TSVs are concurrently tested. The neighboring order K is technology dependent and it is determined such that the test times are minimal without loss in fault coverage. The proposed BIST has lower area than existing interconnect BIST solutions, while the configuration capabilities increase the area by up to 80%. However, due to relative high TSV pitch (10s μm), the area overheads are small.
Onset Latency of Motor Evoked Potentials in Motor Cortical Mapping with Neuronavigated Transcranial Magnetic Stimulation

Cortical motor mapping in pre-surgical applications can be performed using motor evoked potential (MEP) amplitudes evoked with neuronavigated transcranial magnetic stimulation. The MEP latency, which is a more stable parameter than the MEP amplitude, has not so far been utilized in motor mapping. The latency, however, may provide information about the stress in damaged motor pathways, e.g. compression by tumors, which cannot be observed from the MEP amplitudes. Thus, inclusion of this parameter could add valuable information to the presently used technique of MEP amplitude mapping. In this study, the functional cortical representations of first dorsal interosseous (FDI), abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles were mapped in both hemispheres of ten healthy righthanded volunteers. The cortical muscle representations were evaluated by the area and centre of gravity (CoG) by using MEP amplitudes and latencies. As expected, the latency and amplitude CoGs were congruent and were located in the centre of the maps but in a few subjects, instead of a single centre, several loci with short latencies were observed. In conclusion, MEP latencies may be useful in distinguishing the cortical representation areas with the most direct pathways from those pathways with prolonged latencies. However, the potential of latency mapping to identify stressed motor tract connections at the subcortical level will need to be verified in future studies with patients.
Comparison of the API Candida System with the AUXACOLOR System for Identification of Common Yeast Pathogens

ABSTRACT Two commercial systems for the identification of yeasts were evaluated by using 159 clinical isolates that had also been identified by conventional biochemical and morphological methods. The API Candida system correctly identified 146 isolates (91.8%), and the AUXACOLOR system correctly identified 145 isolates (91.2%). However, of the 146 isolates identified by the API Candida system, 23 required supplemental biochemical tests or morphological assessment to obtain the correct identification. The AUXACOLOR system gave no identification in 13 cases (8.2%), while the API Candida system gave an unreadable profile in only one case. Incorrect identifications were more common with the API Candida system (12 isolates; 7.5%) than with the AUXACOLOR system (1 isolate; 0.6%).
Human-Induced Landcover Changes Drive a Diminution of Land Surface Albedo in the Loess Plateau (China)

A large decrease in the land surface albedo of the Loess Plateau was observed from 2000 to 2010, as measured using satellite imagery. In particular, ecological restoration program regions experienced a decrease in peak season land surface albedo exceeding 0.05. In this study, we examined the spatial and temporal patterns of variation during the peak season albedo in the Loess Plateau and analyzed its relationships with changes of anthropogenic and natural factors at the pixel level. Our analysis revealed that increasing grassland coverage due to returning rangeland to grassland could lead to a maximum albedo decrease of 0.030 in peak season. This result highlighted the human-induced land use change in driving the decreasing albedo on an annual scale. There was no significant correlation between precipitation change and albedo reduction. Precipitation could influence the spatial pattern of albedo in drought years by influencing the natural vegetation water requirement. However, the role of precipitation was not obvious in the ecological restoration program regions. This article demonstrates the substantial role that land use change could play in regional-scale albedo change and climate. Finally, some implications for the radiative forcing of land use change are discussed.
Comparison of nose and face mask CPAP therapy for sleep apnoea

BACKGROUND Many patients with sleep apnoea/hypopnoea syndrome (SAHS) find nasal continuous positive airway pressure (CPAP) treatment unsatisfactory due to side effects related to mouth air leakage. A study was performed to compare side effects with face mask and nose mask CPAP therapy in patients with SAHS, with and without uvulopalatopharyngoplasty (U3P). METHODS Twenty newly diagnosed patients with SAHS took part in a randomised double limb trial of face or nose mask CPAP therapy (four weeks per limb) in which CPAP compliance in terms of machine run time was measured and patients answered a symptom questionnaire on side effects resulting from the mask. Ten patients with SAHS with U3P (SAHS/U3P) who were already regular users of nasal CPAP were also given a four week trial of face mask CPAP to compare compliance and symptoms. Ten patients with SAHS were matched with the 10 SAHS/U3P patients for body mass index, age, apnoea/hypopnoea index, and CPAP pressure. Long term compliance was estimated one year after the mask comparison studies. RESULTS For patients with SAHS nightly compliance was higher with a nose mask (mean (SE) 5.3 (0.4) hours/night CPAP) than with a face mask (4.3 (0.5) hours/night CPAP), p = 0.01 (mean difference 1.0 hour/night, 95% CI 1.8 to 0.3). Nose masks were rated more comfortable by 19 of 20 patients (p<0.001) despite more mouth leak related symptoms. For SAHS/U3P patients compliance was marginally higher with nose masks (5.1 (0.7) hours/night CPAP) than with face masks (4.0 (0.8) hours/night CPAP), p = 0.07 (mean difference 1.1 hour/night, 95% CI 2.1 to 0.1). Nose masks were rated more comfortable by seven of 10 patients. There were no significant differences in side effect scores with face and nose masks. At one year nine of 10 SAHS patients and nine of 10 SAHS/U3P patients were still using CPAP. Compliance was 5.4 (0.6) hours/night for the SAHS patients and 3.5 (0.4) hours/night for the SAHS/U3P patients, p = 0.02 (mean difference 1.9 hour/night, 95% CI 3.6 to 0.3). CONCLUSIONS Compliance is greater with nose mask CPAP than with face mask CPAP because the overall comfort is better and compensates for increased symptoms associated with mouth leakage. Improved face mask design is needed.
Implications of Presenting Pre-University Courses Using the Blended e-Learning Approach

This paper discusses two pre-university courses presented at the Technion – Israel Institute of Technology – to two remote sites by means of blended e-Learning, a combination of face -to-face and distance learning. These were refresher courses in mathematics and physics that were offered to students who had completed their schooling early and who live and/or work in places remote from the Technion. These students had taken, in their high schools, advanced classes in these subjects. The aim of the research presented here was to examine what happens to teachers and students participating in distance learning projects. The research team accompanied the courses from conception and planning, throughout their execution, and up to the final meeting. Implications of Synchronous Distance Learning are discussed and some implementation tips are offered.
3D FE model reconstruction and numerical simulation of airflow for the upper airway

Based on CT medical images of ten volunteers, the 3D FE model of the upper airway was recon- structed by using the method of surface rendering. It is comparatively true that the established model reflects the actual anatomical configuration, and the airflow of the whole cavity is simulated numerically and analyzed by the FE method. From the results of the numerical simulation, the airflow distribution in the whole cavity and pharyngeal cavities in the course of respiration can be obtained. The results of the numerical simulation can be used to diagnose the disease related to the anatomical structure and the function of the upper airway and the additional study of the pathogenesis.