Miracle-dz/UniFAR-FTUs huggingface dataset:
HCBP6 Is Involved in the Development of Hepatic Steatosis Induced by High-Fat Diet and CCL4 in Rats.

INTRODUCTION AND AIM Hepatitis C virus core-binding protein 6 (HCBP6) was previously found to be an hepatitis C virus corebinding protein, its biological function remains unclear. Our research aims to investigate the role of HCBP6 in the development of hepatic steatosis induced by high-fat diet and carbon tetrachloride (CCL4) in rats. MATERIAL AND METHODS Eighteen Wistar rats were randomly allocated into 3 groups: control group, model group 1, and model group 2. The control group was treated with a standard diet for 5 weeks. Model groups were treated with high-fat diet and CCL4 injection twice a week for 3 weeks in Group 1 and 5 weeks in Group 2, respectively. After the intervention, hepatic steatosis was observed by histological staining with hematoxylin and eosin (H&E) and Oil Red O staining. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total colesterol (TC), and triglycerides (TGs) were measured. The TG content in liver homogenates was evaluated. Expressions of HCBP6 and SREBP-1c were determined by immunofluorescence, quantitative real-time PCR, and Western blot analysis. RESULTS Hepatic steatosis was successfully induced in model groups. ALT, AST, TC, and TGs elevated in model groups compared with those in control group (P < 0.05). Hepatic steatosis induced by high-fat diet and CCL4 resulted in low expression of HCBP6 and high expression of SREBP-1c in the liver of rats (P < 0.05). CONCLUSION HCBP6 is involved in the development of high-fat diet- and CCL4-induced hepatic steatosis and related negatively with SREBP-1c.
Protective Effect of Artemisia argyi and Its Flavonoid Constituents against Contrast-Induced Cytotoxicity by Iodixanol in LLC-PK1 Cells

Preventive effects and corresponding molecular mechanisms of mugwort (Artemisia argyi) extract and its flavonoid constituents on contrast-induced nephrotoxicity were explored in the present study. We treated cultured LLC-PK1 cells with iodixanol to induce contrast-induced nephrotoxicity, and found that A. argyi extracts ameliorated the reduction in cellular viability following iodixanol treatment. The anti-apoptotic effect of A. argyi extracts on contrast-induced nephrotoxicity was mediated by the inhibition of mitogen-activated protein kinase (MAPK) phosphorylation and the activation of caspases. The flavonoid compounds isolated from A. argyi improved the viability of iodixanol-treated cells against contrast-induced nephrotoxicity. Seven compounds (1, 2, 3, 15, 16, 18, and 19) from 19 flavonoids exerted a significant protective effect. Based on the in silico oral-bioavailability and drug-likeness assessment, which evaluate the drug potential of these compounds, compound 2 (artemetin) showed the highest oral bioavailability (49.55%) and drug-likeness (0.48) values. We further investigated the compound–target–disease network of compound 2, and proliferator-activated receptor gamma (PPAR-γ) emerged as a predicted key marker for the treatment of contrast-induced nephrotoxicity. Consequently, compound 2 was the preferred candidate, and its protective effect was mediated by inhibiting the contrast-induced inflammatory response through activation of PPAR-γ and inhibition of MAPK phosphorylation and activation of caspases.
Criterion A of the AMPD in HiTOP

ABSTRACT The categorical model of personality disorder classification in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (5th ed. [DSM–5]; American Psychiatric Association, 2013) is highly and fundamentally problematic. Proposed for DSM–5 and provided within Section III (for Emerging Measures and Models) was the Alternative Model of Personality Disorder (AMPD) classification, consisting of Criterion A (self-interpersonal deficits) and Criterion B (maladaptive personality traits). A proposed alternative to the DSM–5 more generally is an empirically based dimensional organization of psychopathology identified as the Hierarchical Taxonomy of Psychopathology (HiTOP; Kotov et al., 2017). HiTOP currently includes, at the highest level, a general factor of psychopathology. Further down are the five domains of detachment, antagonistic externalizing, disinhibited externalizing, thought disorder, and internalizing (along with a provisional sixth somatoform dimension) that align with Criterion B. The purpose of this article is to discuss the potential inclusion and placement of the self-interpersonal deficits of the DSM–5 Section III Criterion A within HiTOP.
Myocarditis Secondary to Mesalamine-Induced Cardiotoxicity in a Patient with Ulcerative Colitis

Development of cardiac manifestations in patients diagnosed with inflammatory bowel disease undergoing treatment with mesalamine is a rare. When this occurs, it can be difficult to tease out the primary etiology, as both IBD and mesalamine can cause cardiac manifestations independently of each other. The exact mechanism of mesalamine-induced cardiotoxicity is yet to be determined although several mechanisms have been described. We present the case of a gentleman with nonexertional chest pain in the setting of ulcerative colitis exacerbation believed to have occurred secondary to mesalamine.
Modification and validation of the multidimensional scale of perceived social support for Chinese school teachers

Abstract This study aims to investigate the psychometric properties of the revised multidimensional scale of perceived social support (R-MSPSS) for Chinese school teachers. A questionnaire comprising the R-MSPSS and other psychological measures was administered to a sample of 539 school teachers in Hong Kong. A series of confirmatory factor analysis was conducted to examine the construct validity of the Scale. The results indicated a moderate fit of the proposed model with improved fit after covariance of error terms were added. Convergent and discriminant validity of the Scale were assessed by associations with self-esteem and burnout symptoms. The results of most correlations were statistically significant and in predicted directions, which will provide a fertile ground in supporting the use of the R-MSPSS for measuring social support for Hong Kong teachers. Further modifications in differentiating those items for measuring perceived social support from school principal and colleagues are suggested.
Dispersion Bound for the Wyner-Ahlswede-Körner Network via Reverse Hypercontractivity on Types

Using the functional-entropic duality and the reverse hypercontractivity of the transposition semigroup, we lower bound the error probability for each joint type in the Wyner-Ahlswede-Korner problem. Then by averaging the error probability over types, we lower bound the c-dispersion (which characterizes the second-order behavior of the weighted sum of the rates of the two compressors when a nonvanishing error probability is small) as the variance of the gradient of $\inf_{P_{U\vert X}}\{cH(Y\vert U)+ \ I(U;X)\}$ with respect to $Q_{XY}$, the per-letter side information and source distribution. On the other hand, using the method of types we derive a new upper bound on the c-dispersion, which improves the existing upper bounds but has a gap to the aforementioned lower bound.
Predictors of quality of life for autistic adults

Research with adults on the autism spectrum is as yet limited in scope and quality. The present study describes quality of life (QoL) of a large sample of autistic adults in the UK and investigates characteristics that may be predictive of QoL. A total of 370 autistic adults from the Adult Autism Spectrum Cohort‐UK (ASC‐UK) completed the WHOQoL‐BREF, and the Social Responsiveness Scale (SRS, autism symptom severity), along with the ASC‐UK registration questionnaire giving information on mental health and their life situation. QoL for autistic adults was lower than for the general population for each WHOQoL domain. Younger participants reported higher QoL than older participants in psychological and environment domains. Males reported higher physical QoL than females, and females reported higher social QoL than males. Significant positive predictors of QoL were: being employed (physical QoL), receiving support (social and environment QoL), and being in a relationship (social QoL). Having a mental health condition and higher SRS total score were negative predictors of QoL across all four domains. Autistic adults require access to effective mental health interventions, and informal and formal support for their social difficulties, to improve their quality of life. Autism Res 2018, 11: 1138–1147. © 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc.
In vivo impact testing on a lengthened femur with external fixation: a future option for the non-invasive monitoring of fracture healing?

Non-invasive methods for assessing fracture healing are crucial for biomedical engineers. An approach based on mechanical vibrations was tried out in the 1990s, but was soon abandoned due to insufficiently advanced technologies. The same approach is re-proposed in the present study in order to monitor the healing process of a lengthened femur with an external fixator. The pins screwed into the bone were exploited for the impact testing (IT) to excite the bone and capture its response. Transmission through the soft tissues was thus prevented, and the quality of the signals was improved. Impact tests were performed every three to four weeks for five months. Unfortunately, after seven weeks, some pins were removed due to infection, and thus, the system was modified. Two different configurations were considered: before and after pin removal. An additional configuration was examined in the last two sessions, when the fixator body was removed, while four pins were left in the femur. The evolution of the frequency response function and of the resonant frequencies of the system were analysed for the duration of the monitoring period. The IT results were compared to the indications provided by X-ray images. During the evolution of the callus from the soft phase to the woven bone, the resonant frequencies of the system were found to increase by approximately 2–3% per week. The largest increase (approx. 22%) was observed for the first resonant frequency. After formation of the woven bone, the vibratory response remained almost the same, suggesting that the healing assessment could be related to the relative variation in the resonant frequencies. The results presented support the application of the IT approach for fracture healing assessment.
Mixed Equilibrium Solution of Time-Inconsistent Stochastic LQ Problem

In this paper, we propose a novel equilibrium solution notion for the time-inconsistent stochastic linear-quadratic optimal control problem. This notion is called the mixed equilibrium solution, which consists of two parts: a pure-feedback-strategy part and an open-loop-control part. When the pure-feedback-strategy part is zero or the open-loop-control part does not depend on the initial state, the mixed equilibrium solution reduces to the open-loop equilibrium control and the feedback equilibrium strategy, respectively. Using a maximum-principle-like methodology with forward-backward stochastic difference equations, a necessary and sufficient condition is established to characterize the existence of a mixed equilibrium solution. Then, by decoupling the forward-backward stochastic difference equations, three sets of difference equations, which together portray the existence of a mixed equilibrium solution, are obtained. Moreover, the case with a fixed time-state initial pair and the case with all the initial pairs are separately investigated. Furthermore, an example is constructed to show that the mixed equilibrium solution exists for all the initial pairs, although neither the open-loop equilibrium control nor the feedback equilibrium strategy exists for some initial pairs.
When do people bet on their selves? The role of global self-concepts in decision making

Abstract Previous research suggests that behavior is generally predicted by specific self-concepts but not global self-concepts. A study was conducted to examine the conditions under which global conceptions of self are predictive of decision-making. Participants were given the opportunity to bet lottery tickets on their performance in the “Utah Challenge” competition. Both global and specific self-concepts independently predicted betting on specific known contests and betting on a contest that was unknown. Global but not specific self-concepts independently predicted betting on a multi-faceted contest. Mediation analyses suggest that self-concepts guide decisions by influencing the perceived likelihood of success. Participants’ were more overconfident about their chances of winning when a task was unknown rather than familiar.
A Model of Chronic Exposure to Unpredictable Mild Socio-Environmental Stressors Replicates Some Spaceflight-Induced Immunological Changes

During spaceflight, astronauts face radiations, mechanical, and socio-environmental stressors. To determine the impact of chronic socio-environmental stressors on immunity, we exposed adult male mice to chronic unpredictable mild psychosocial and environmental stressors (CUMS model) for 3 weeks. This duration was chosen to simulate a long flight at the human scale. Our data show that this combination of stressors induces an increase of serum IgA, a reduction of normalized splenic mass and tends to reduce the production of pro-inflammatory cytokines, as previously reported during or after space missions. However, CUMS did not modify major splenic lymphocyte sub-populations and the proliferative responses of splenocytes suggesting that these changes could be due to other factors such as gravity changes. Thus, CUMS, which is an easy to implement model, could contribute to deepen our understanding of some spaceflight-associated immune alterations and could be useful to test countermeasures.
PENGARUH KOMPETENSI GURU TERHADAP KINERJA GURU SMP NEGERI 6 SINGARAJA

Penelitian ini bertujuan untuk mengetahui (1) kompetensi pedagogik, (2) kompetensi profesional, (3) kompetensi sosial, (4) kompetensi kepribadian secara parsial terhadap kinerja guru SMP Negeri 6 Singaraja dan (5) pengaruh kompetensi guru secara simultan terhadap kinerja guru SMP Negeri 6 Singaraja. Jenis penelitian ini termasuk dalam jenis penelitian kausalitas. Subjek penelitian ini adalah kepala SMP Negeri 6 Singaraja dengan jumlah responden sebanyak 70 guru, dan yang menjadi objek dalam penelitian ini kompetensi guru dan kinerja guru. Metode pengumpulan data yang digunakan adalah dokumentasi dan kuisioner. Data dianalisis dengan analisis regresi linier berganda dengan SPSS 17.0 for windows yang meliputi uji t dan uji F. Hasil penelitian menunjukkan bahwa (1) kompetensi pedagogik berpengaruh signifikan terhadap kinerja guru dengan hasil thitung 2,545> ttabel 1,994 dan p-value 0,013 ttabel 1,994 dan p-value 0,041 ttabel 1,994 dan p-value 0,029 ttabel 1,994 dan p-value 0,003 Ftabel = 2,740 dan ditunjukkan dengan nilai probabilitas uji F 0,000 lebih kecil dari α = 0,05. Nilai koefisien determinasi disesuaikan sebesar 0,726 artinya 72,6% kinerja guru dipengaruhi oleh kompetensi guru sedangkan sisanya sebesar 27,4% dipengaruhi oleh faktor lain. Kata Kunci : kompetensi guru, kinerja guru This study aims to determine (1) pedagogical, (2) professional competence, (3) social competence, (4) personal competence partially on the performance of teachers SMPN 6 Singaraja and (5) the effect of teacher competence simultaneously on teacher performance SMP State 6 Singaraja. This study is in this type of research causality. This research subject is the head of SMPN 6 Singaraja with the number of respondents as many as 70 teachers, and which is the object of this research competence of teachers and teacher performance. Data collection methods used were documentation and questionnaires. Data were analyzed with multiple linear regression analysis with SPSS 17.0 for Windows that includes t test and F. The results showed that (1) the pedagogic competence significantly influence the performance of teachers with the results tcount 2,545> t table 1.994 and p-value 0.013 t table 1.994 and p-value 0.041 t table 1.994 and p-value 0.029 ttable 1.994 and p-value 0.003 F table = 2.740 and is indicated by the F test probability value 0,000 smaller than α = 0.05. Adjusted determination coefficient of 0.726 means that 72.6% of teacher performance is influenced by the competence of teachers while the remaining 27.4% is influenced by other factors. keyword : competence of teachers, teacher performance
Changes in quality of life and health status in patients with extracorporeal life support: A prospective longitudinal study

Background Extracorporeal life support (ECLS) provides emergency pulmonary and cardiac assistance for patients in respiratory or cardiac failure. Most studies evaluate the success of ECLS based on patients’ survival rate. However, the trajectory of health status and quality of life (QOL) should also be important considerations. The study’s aim was to explore changes in health status and QOL in adult patients weaned from ECLS who survived to hospital discharge over a one-year period. Study design A prospective longitudinal study was conducted from April 2012 to September 2014. A convenience sample of patients who had undergone ECLS was followed for one-year after hospital discharge. Heath status was measured with a physical activity scale, the Centre for Epidemiologic Studies Depression scale, and a social support scale; we assessed quality of life with the physical and mental component summary scales of the Short-Form 36 Health Survey. Changes in depression, social support, physical activity and QOL were analysed with generalized estimating equations at 3-month intervals; participants’ QOL at 12 months after discharge was compared with the general population. Results A total of 231 patients received ECLS during the study period. Sixty-five patients survived to hospital discharge (28% survival rate); 32 participants completed the study. Data showed scores for physical activity increased significantly over time (p < .001), while depression and social support significantly decreased (p < .05 and p < .001, respectively). Participants with veno-venous ECLS had higher scores for depression than participants with veno-arterial ECLS (p < .05). PCS scores significantly increased at 9, and 12 months after discharge (p < .05 and p < .001, respectively). There was no significant change in MCS scores. Conclusions This was a preliminary study of patients with ECLS following hospital discharge over a one-year period. One year following hospital discharge survivors of ECLS continued to experience physical complications and some continued to have depressive symptoms; the level of social support was significantly lower after hospital discharge. Healthcare professionals should understand the trajectory of health status and QOL after discharge, which can help developing evidence-based interventions and improve QOL for survivors of ECLS.
Digital zooplankton image analysis using the ZooScan integrated system

ZooScan with ZooProcess and Plankton Identifier (PkID) software is an integrated analysis system for acquisition and classification of digital zooplankton images from preserved zooplankton samples. Zooplankton samples are digitized by the ZooScan and processed by ZooProcess and PkID in order to detect, enumerate, measure and classify the digitized objects. Here we present a semi-automatic approach that entails automated classification of images followed by manual validation, which allows rapid and accurate classification of zooplankton and abiotic objects. We demonstrate this approach with a biweekly zooplankton time series from the Bay of Villefranche-sur-mer, France. The classification approach proposed here provides a practical compromise between a fully automatic method with varying degrees of bias and a manual but accurate classification of zooplankton. We also evaluate the appropriate number of images to include in digital learning sets and compare the accuracy of six classification algorithms. We evaluate the accuracy of the ZooScan for automated measurements of body size and present relationships between machine measures of size and C and N content of selected zooplankton taxa. We demonstrate that the ZooScan system can produce useful measures of zooplankton abundance, biomass and size spectra, for a variety of ecological studies.
Identification of multiple strains of Porphyromonas gingivalis using heteroduplex polymerase chain reaction in varying severity of chronic periodontitis

Aim: Research has demonstrated that there are multiple strains of Porphyromonas gingivalis with varying potency to cause periodontal disease. The current study aims at using heteroduplex polymerase chain reaction (PCR) to detect the strain diversity of P. gingivalis in periodontitis lesions of varying severity in a sample of the Indian population. Materials and Methods: Subgingival plaque samples were collected from 60 individuals with varying severity of chronic periodontitis and 30 individuals with a clinically healthy periodontium. The samples were subjected to PCR analysis to identify P. gingivalis, followed by heteroduplex analysis to identify the strain diversity in a given sample. Bacterial culture was carried out as a comparative standard. Results: Of the 56 samples that were positive for P. gingivalis by PCR, 54 samples yielded eight different heteroduplex patterns. Analysis of these patterns indicated that two strains of P. gingivalis were present in 41 individuals (45.6%) and three strains were present in 13 individuals (14.4%). Detection of P. gingivalis by PCR was significantly more in the periodontitis group as compared to the healthy group. Conclusions: Species-specific PCR and heteroduplex analysis provide a simple and accurate method to analyse the strain diversity of P. gingivalis. P. gingivalis was detected in both healthy periodontal sites as well as sites with periodontitis. The presence of two or three P. gingivalis strains was seen in 60% of the samples.