Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical analysis of an Antarctic ice core—towards an integration of micro- and macrodynamics of polar ice*

Microstructures from deep ice cores reflect the dynamic conditions of the drill location as well as the thermodynamic history of the drill site and catchment area in great detail. Ice core parameters (crystal lattice-preferred orientation (LPO), grain size, grain shape), mesostructures (visual stratigraphy) as well as borehole deformation were measured in a deep ice core drilled at Kohnen Station, Dronning Maud Land (DML), Antarctica. These observations are used to characterize the local dynamic setting and its rheological as well as microstructural effects at the EDML ice core drilling site (European Project for Ice Coring in Antarctica in DML). The results suggest a division of the core into five distinct sections, interpreted as the effects of changing deformation boundary conditions from triaxial deformation with horizontal extension to bedrock-parallel shear. Region 1 (uppermost approx. 450 m depth) with still small macroscopic strain is dominated by compression of bubbles and strong strain and recrystallization localization. Region 2 (approx. 450–1700 m depth) shows a girdle-type LPO with the girdle plane being perpendicular to grain elongations, which indicates triaxial deformation with dominating horizontal extension. In this region (approx. 1000 m depth), the first subtle traces of shear deformation are observed in the shape-preferred orientation (SPO) by inclination of the grain elongation. Region 3 (approx. 1700–2030 m depth) represents a transitional regime between triaxial deformation and dominance of shear, which becomes apparent in the progression of the girdle to a single maximum LPO and increasing obliqueness of grain elongations. The fully developed single maximum LPO in region 4 (approx. 2030–2385 m depth) is an indicator of shear dominance. Region 5 (below approx. 2385 m depth) is marked by signs of strong shear, such as strong SPO values of grain elongation and strong kink folding of visual layers. The details of structural observations are compared with results from a numerical ice sheet model (PISM, isotropic) for comparison of strain rate trends predicted from the large-scale geometry of the ice sheet and borehole logging data. This comparison confirms the segmentation into these depth regions and in turn provides a wider view of the ice sheet. This article is part of the themed issue ‘Microdynamics of ice’.
Sources of the porcine testis innervation

This study was carried out on three adult male pigs of the large White Polish breed weighing 110–130 kg each. The animals were anaesthetised and injected with retrograde tracer Fast Blue (FB) into right testis. Three weeks later, the pigs were deeply anaesthetised and perfused transcardially with fixative (4% paraformaldehyde in 0.1 m phosphate buffer pH 7.4). Collected ganglia were cut with freezing microtome into 12‐ μm‐thick sections. The sections were examined under a fluorescent microscope (Zeiss). FB‐positive neurones were found in pelvic ganglia (anterior pelvic ganglion) (15.4% of all FB+ neurones), prevertebral ganglia (caudal mesenteric, testicular, aortico‐renal and renal ganglia) (59% of all FB+ neurones), sympathetic chain ganglia (last four lumbar and first three sacral ganglia) (18.1% of all FB+ neurones) and dorsal root ganglia (DRG) (first three lumbar and first three sacral ganglia) (7.4% of all FB+ neurones). The majority of FB‐positive nerve cell bodies were observed in ipsilateral ganglia, but they were also found in contralateral ganglia (approximately 85% and 15% respectively). Thus, FB‐positive neurones were located in the left prevertebral, sympathetic chain and DRG, but surprisingly, they were absent in left anterior pelvic ganglia.
The Cold and Hot Gas Content of Fine-Structure E and S0 Galaxies

We investigate trends of the cold and hot gas content of early-type galaxies with the presence of optical morphological peculiarities, as measured by the fine-structure index Σ. H I mapping observations from the literature are used to track the cold gas content, and archival ROSAT Position Sensitive Proportional Counter data are used to quantify the hot gas content. We find that E and S0 galaxies with a high incidence of optical peculiarities are exclusively X-ray underluminous and, therefore, deficient in hot gas. In contrast, more relaxed galaxies with little or no signs of optical peculiarities span a wide range of X-ray luminosities. That is, the X-ray excess anticorrelates with Σ. There appears to be no similar trend of cold gas content with either fine-structure index or X-ray content. The fact that only apparently relaxed E and S0 galaxies are strong X-ray emitters is consistent with the hypothesis that after strong disturbances, such as a merger, hot gas halos build up over a timescale of several gigayears. This is consistent with the expected mass loss from stars.
Cytokines and the neurodevelopmental basis of mental illness

Epidemiological studies suggest that prenatal exposure to different types of viral or bacterial infections may be associated with similar outcomes; i.e., an increased risk of mental illness disorders in the offspring. Infections arising from various causes have similar debilitating effects in later life, suggesting that the exact pathogen may not be the critical factor in determining the neurological and cognitive outcome in the offspring. Instead, it is thought that response of the innate immune system, specifically the increased production of inflammatory cytokines, may be the critical mediator in altering fetal brain development pre-disposing the offspring to mental illness disorders later in life. Inflammatory cytokines are essential for normal brain development. Factors such as the site of cytokine production, a change in balance between anti- and pro- inflammatory cytokines, placental transfer of cytokines, the effects of cytokines on glial cells, and the effects of glucocorticoids are important when evaluating the impact of maternal infection on fetal brain development. Although it is clear that cytokines are altered in the fetal brain following maternal infection, further evidence is required to determine if cytokines are the critical factor that alters the trajectory of brain development, subsequently leading to postnatal behavioral and neurological abnormalities.
Assessing autonomic dysfunction in early diabetic neuropathy

Objective: Autonomic symptoms may occur frequently in diabetic and other neuropathies. There is a need to develop a simple instrument to measure autonomic symptoms in subjects with neuropathy and to test the validity of the instrument. Methods: The Survey of Autonomic Symptoms (SAS) consists of 11 items in women and 12 in men. Each item is rated by an impact score ranging from 1 (least severe) to 5 (most severe). The SAS was tested in observational studies and compared to a previously validated autonomic scale, the Autonomic Symptom Profile (ASP), and to a series of autonomic tests. Results: The SAS was tested in 30 healthy controls and 62 subjects with neuropathy and impaired glucose tolerance or newly diagnosed diabetes. An increased SAS score was associated with the previously validated ASP (rank order correlation = 0.68; p < 0.0001) and with quantitative measures of autonomic function: a reduced quantitative sudomotor axon reflex test sweat volume (0.31; p < 0.05) and an abnormal 30:15 ratio (0.53; p < 0.01). The SAS shows a high sensitivity and specificity (area under the receiver operating characteristic curve 0.828) that compares favorably with the ASP. The SAS scale domains had a good internal consistency and reliability (Cronbach α = 0.76). The SAS symptom score was increased in neuropathy (95% confidence interval [CI] 2.99–4.14) compared to control (95% CI 0.58–1.69; p < 0.0001) subjects. Conclusions: The SAS is a new, valid, easily administered instrument to measure autonomic symptoms in early diabetic neuropathy and would be of value in assessing neuropathic autonomic symptoms in clinical trials and epidemiologic studies.
Ocean acidification increases the vulnerability of native oysters to predation by invasive snails

There is growing concern that global environmental change might exacerbate the ecological impacts of invasive species by increasing their per capita effects on native species. However, the mechanisms underlying such shifts in interaction strength are poorly understood. Here, we test whether ocean acidification, driven by elevated seawater pCO2, increases the susceptibility of native Olympia oysters to predation by invasive snails. Oysters raised under elevated pCO2 experienced a 20% increase in drilling predation. When presented alongside control oysters in a choice experiment, 48% more high-CO2 oysters were consumed. The invasive snails were tolerant of elevated CO2 with no change in feeding behaviour. Oysters raised under acidified conditions did not have thinner shells, but were 29–40% smaller than control oysters, and these smaller individuals were consumed at disproportionately greater rates. Reduction in prey size is a common response to environmental stress that may drive increasing per capita effects of stress-tolerant invasive predators.
Inhibition of I‐Ad‐, but not Db‐restricted peptide‐induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice

Thymocytes differentiate by positive and negative selection of immature CD4+ CD8+ T cells. Negative selection occurs by default or by high‐affinity recognition of peptides bound to proteins encoded by the major histocompatibility complex (MHC). MHC class I molecules are expressed on many different cell types, although at different levels, whereas MHC class II molecules are selectively expressed on thymic epithelial cells (TEC) and dendritic cells (DC). We investigated the role of the glucocorticoid receptor (GR) in thymic negative selection using the receptor antagonist RU486. Glucocorticoids (GC) are known to be potent inducers of apoptosis in CD4+ CD8+ thymocytes, and we have earlier shown that anti‐CD3‐induced thymic apoptosis can be blocked by RU486 in vivo. We now show that anti‐CD3 induces thymic apoptosis in mice that have been adrenalectomized (ADX), and that RU486 inhibits anti‐CD3 antibody‐mediated thymocyte killing in newborn thymic organ cultures. Thymocyte apoptosis induced by ovalbumin peptide OVA323–339 treatment of mice transgenic for the DO11.10T cell receptor (TCR), which recognizes this peptide in the context of I‐Ad, was found to be inhibited by RU486. These mice responded to peptide treatment by an extensive activation of the peripheral immune system, which became lethal in 60% of the mice when accompanied by simultaneous RU486 treatment. In contrast, RU486 had no effect on thymic apoptosis induced by the influenza A nucleoprotein NP366–374 peptide, recognized in context of Db, in F5 TCR transgenic mice. We interpret the results to demonstrate that different deletion systems operate in the thymus. We propose that endogenous GC may be important for negative selection by default and by high‐affinity recognition of endogenous MHC‐presented peptides on TEC.
The Precautionary Principle and Unnecessary Precautionary Action

Claims that a specific chemical, technology or activity is a false negative or a false positive are often made and used as an argument either for or against the application of the Precautionary Principle in the future. False positives could be defined as risks where actions were taken in the face of incomplete knowledge on the basis of a precautionary approach that later turned out to be unnecessary. The purpose of this study is to identify false positives and to analyze these to learn lessons from the past that can be valuable for future regulatory decision-making regarding human health and the environment. The environmental and health literature was examined for proclaimed “false positives” often said to be diverting scarce resources from real risks or even worse creating new more problematic risks. This review was narrowed down to false positives seen in the light of today’s knowledge and recognized uncertainty. Four cases were identified: the Southern Corn Leaf Blight, the Swine Flu affair, saccharin, and food irradiation in relation to consumer health. The identified cases were analysed to identify when and why actions were initially taken, when and why it was realized that the believed risk was false and what the overall socio-economic costs and benefits were. The study shows that the actual number of false positives is very limited and that a great deal of the cases often mentioned in the literature are not real “false positives”, but fall into a wide variety of different risk categories. Seen from a public health and environmental perspective, the false positives generally did not have great impact, either positive or negative. From a socio-economic perspective false positives did have an impact, mostly on the industry directly affected by regulatory action, but the overall impact was not always negative since it sparked innovation within industry, science and government. This leads to the conclusion that fear of false positives is not a reasonable argument against future application of the Precautionary Principle.
Anticipatory and Reactive Crouching of Pea Aphids in Response to Environmental Perturbations

ABSTRACT Animals use different strategies to deal with changing environmental conditions. While standing and feeding on their host plant, aphids (Hemiptera: Aphididae) may be exposed to detrimental environmental perturbations, such as strong winds. If aphids are forcibly blown off the plant and spend time on the ground, they will face additional dangers by both ground-dwelling predators and detrimental soil temperature. It is therefore adaptive for aphids to behave in a way that lowers the risk of being removed from the plant. We observed that pea aphids (Acyrthosiphon pisum (Harris) ) display a specific crouched body posture, previously undescribed, which reduces their chance of being carried off from the plant by sudden winds. We exposed aphids in the laboratory to different cues indicative of a windy environment: wind, plant vibration, and visual stimuli. We found that aphids crouch in two situations: 1) reactively, when they are being pulled by a continuous gust of wind threatening to dislodge them. 2) Anticipatorily, when environmental cues, such as plant vibration or continuous movement near their host plant, may signify that sudden wind gusts are expected. Crouching aphids were less likely to be dislodged by a sudden air stream or plant vibration than were aphids that did not crouch. Crouching thus improves the aphids' chances of remaining on their host plant under unfavorable environmental conditions.
Relationship between the size and margin status of ductal carcinoma in situ of the breast and residual disease.

BACKGROUND For women with ductal carcinoma in situ (DCIS) of the breast who have been treated with breastconserving surgery, the usefulness of size and surgical margin status (i.e., presence or absence of disease at the point of excision) as prognostic factors for predicting residual disease has not been well established. This study was conducted to determine more clearly the relationship between size and margin status of mammary DCIS to residual disease. METHODS The pathology records of 232 consecutive patients with mammary DCIS who had been initially treated with lumpectomy at the University Hospitals of Cleveland were retrospectively reviewed. The size of the DCIS and the surgical margins of lumpectomy were analyzed. Residual disease was defined as the persistence of DCIS in the re-excision and/or mastectomy specimens. RESULTS Residual disease was found in 15 of 101 patients with DCIS of less than 1.0 cm in longest dimension, in 27 of 96 patients with DCIS of 1.0-2.4 cm in size, and in 24 of 35 patients with DCIS of greater than or equal to 2.5 cm in size (P<.001). Residual disease was found in 30 of 77 patients with DCIS and positive margins, in 11 of 59 patients with DCIS and close margins (< or =1mm), and in 10 of 73 patients with DCIS and negative margins (>1 mm) (P =.001). In multivariate analysis, the occurrence of residual disease was associated with large tumor size (i.e., > or =2.5 cm) (odds ratio [OR] = 7.7; 95% confidence interval [CI] = 3.13-20.00; two-sided P = .0001) and with positive margin status (OR = 2.2; 95% CI = 1.02-4.55; two-sided P = .04). CONCLUSIONS The size and margin status of DCIS each were found to be independent predictors of residual disease.
A simple Pearson distribution based detector with applications to time-hopping multiuser UWB receiver design

Application of a powerful statistical tool, the Pearson distribution family, to signal detection problems is investigated in communications literature for the first time. In order to design high performance detectors, we use a method of moments which relies on the Pearson distribution system to estimate probability density function (PDF) of the additive noise or interference. Using the Pearson PDF as approximation to the true PDF of the noise/interference, we present a novel and simple detector structure which can be used in a variety of detection problems. The TH-UWB receiver design is studied as an example and demonstration of the proposed detection approach. It is shown that the Pearson distribution based detector achieves high performance in a wide range of noise/interference conditions for TH-UWB systems, which suffer from non-Gaussian, impulse-like multiple access interference.
Individual and Contextual Correlates of Trust in Media Across 44 Countries

Media research demonstrates that audience trust in the news media is a highly consequential factor, shaping audience selection of and response to media, and potentially impacting citizens’ perceptions of the political system at large. Still, our knowledge about the correlates of trust in media is limited. Only a few studies have utilized a correlational design to explore the associations between trust in media and other factors, and almost all of these studies originate in the U.S. context. The current investigation utilizes data from 44 diverse countries (n = 57,847), collected as part of the World Values Survey, to broaden our understanding of trust in media. The aim is two-fold—to learn about individual-level correlates across contexts and to demonstrate that macro-level factors play a part in shaping such trust. Our findings indicate that levels of political interest, interpersonal trust, and exposure to television news and newspapers are positively correlated with trust in media, while education and exposure to news on the Internet are negatively associated. On the macro level, postmaterialism emerged as a consistent predictor of trust in media. State ownership of the media industry did not have a main effect on trust in media after controlling for other factors. However, an interaction was found between state ownership and level of democracy: state ownership of television is positively associated with media trust in democratic societies and negatively associated with trust in media in nondemocratic societies.
Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity

Background Iron dysregulation is a potential contributor to the pathology of obesity-related metabolic complications. KK/HIJ (KK) mice, a polygenic obese mouse model, have elevated serum iron levels. A subset of KK male mice display a bronzing of epididymal adipose tissue (eAT) associated with >100-fold (p<0.001) higher iron concentration. Methods To further phenotype and characterize the adipose tissue iron overload, 27 male KK mice were evaluated. 14 had bronzing eAT and 13 had normal appearing eAT. Fasting serum and tissues were collected for iron content, qPCR, histology and western blot. Results High iron levels were confirmed in bronzing eAT (High Iron group, HI) versus normal iron level (NI) in normal appearing eAT. Surprisingly, iron levels in subcutaneous and brown adipose depots were not different between the groups (p>0.05). The eAT histology revealed iron retention, macrophage clustering, tissue fibrosis, cell death as well as accumulation of HIF-2α in the high iron eAT. qPCR showed significantly decreased Lep (leptin) and AdipoQ (adiponectin), whereas Tnfα (tumor necrosis factor α), and Slc40a1 (ferroportin) were up-regulated in HI (p<0.05). Elevated HIF-2α, oxidative stress and local insulin signaling loss was also observed. Significance Our data suggest that deposition of iron in adipose tissue is limited to the epididymal depot in male KK mice. A robust adipose tissue remodeling is concomitant with the high iron concentration, which causes local adipose tissue insulin resistance.
Likelihood-Maximizing-Based Multiband Spectral Subtraction for Robust Speech Recognition

Automatic speech recognition performance degrades significantly when speech is affected by environmental noise. Nowadays, the major challenge is to achieve good robustness in adverse noisy conditions so that automatic speech recognizers can be used in real situations. Spectral subtraction (SS) is a well-known and effective approach; it was originally designed for improving the quality of speech signal judged by human listeners. SS techniques usually improve the quality and intelligibility of speech signal while speech recognition systems need compensation techniques to reduce mismatch between noisy speech features and clean trained acoustic model. Nevertheless, correlation can be expected between speech quality improvement and the increase in recognition accuracy. This paper proposes a novel approach for solving this problem by considering SS and the speech recognizer not as two independent entities cascaded together, but rather as two interconnected components of a single system, sharing the common goal of improved speech recognition accuracy. This will incorporate important information of the statistical models of the recognition engine as a feedback for tuning SS parameters. By using this architecture, we overcome the drawbacks of previously proposed methods and achieve better recognition accuracy. Experimental evaluations show that the proposed method can achieve significant improvement of recognition rates across a wide range of signal to noise ratios.
Chronic intrathecal infusions after spinal cord injury cause scarring and compression

Intrathecal infusions are used in a number of rodent studies to deliver substances to the injured spinal cord. Whereas this method has been successful in certain paradigms, two potential limitations of this model have not been extensively reported: (1) scar formation at the catheter tip, which can lead to infusion failure, and (2) damage to the spinal cord caused by the catheter itself. Thus, the purpose of the present study was threefold: (1) to determine intrathecal infusion efficiency over 14 days following spinal cord injury; (2) to examine possible secondary damage caused by intrathecal tubing; and (3) to explore whether alternative protocols that avoid such damage are effective. Adult Fischer 344 rats were subjected to spinal cord lesions at T7, followed by placement of an intrathecal catheter attached to an Alzet minipump. Seven or 14 days following injury and catheter placement, tube patency was evaluated by diffusion of Evans Blue dye from the minipump. Results indicate that infusion was efficient 7 days following injury but was markedly reduced after 14 days. Further, histology and immunocytochemistry 14 days after injury demonstrated compression damage to the cord where the tubing rested. Alternative protocols, including intrathecal infusions through metal cannulae, or “drip” infusions directly over the lesion, did not improve delivery. These data suggest that results from rodent studies using infusion from catheters placed adjacent to lesion sites may be attributable to acute or subacute effects of the delivered substance. Future rodent studies using intrathecal infusions should include rigorous evaluation of infusion efficiency and possible secondary tissue damage. Microsc. Res. Tech. 54:317–324, 2001. © 2001 Wiley‐Liss, Inc.