Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonresident Fathers’ Financial Support, Informal Instrumental Support, Mothers’ Parenting, and Child Development in Single-Mother Families With Low Income

This study examines the relationships among nonresident fathers’ financial support, informal instrumental support, mothers’ parenting and parenting stress, and their children’s behavioral and cognitive development in single-mother families with low income. Informed by stress-coping and social support models, this study estimates the mediating effects of nonresident fathers’ financial support on children’s outcomes transmitted through mothers’ parenting and parenting stress. The analyses use the longitudinal data from a subsample of 679 single mothers in the Fragile Families and Child Wellbeing Study. Results suggest that nonresident fathers’ financial support is directly associated with children’s cognitive development. Nonresident fathers’ financial support is found to have indirect effects on children’s behavior problems and cognitive development transmitted through mothers’ parenting and parenting stress. Informal instrumental support is directly and indirectly associated with both outcomes of children transmitted through maternal economic hardship, parenting, and parenting stress. The study discusses the policy and practice implications of these findings.
Paroxetine and Offenders: A Pilot Study

Recidivism rates for offenders constantly reflect disappointment. In an effort to reduce the rate of recidivism, the SSRI (selective seroton in reuptake inhibitor) medication paroxetine was attempted with a small group of offenders in a community-based program About half the offenders dropped out after one or two sessions, but 14 completed 3 months of treatment. These had a reduction in depressive and obsessive-conpulsive disorder symptoms, but it is difficult to determine the impact on the total rehabilitation program for the offenders. The implications for further research and clinical work are discussed
Differences in Emotional Responsivity and Anger in Athletes and Nonathletes: Startle Reflex Modulation and Attributional Response

Studies of sport participation that include emotional responses, particularly anger, are frequently flawed because measures consist of associative paper–pencil inventories and archival data. In the present study, startle response (an aversive reflex) was enhanced during an unpleasant emotional state and diminished in a pleasant emotional context. Nonsignificant differences on this dispositional measure between 36 athletes and nonathletes did not replicate findings differing normals and psychopaths (Patrick, Bradley, & Lang, 1993) on emotional responsivity. Similarity was also apparent in experiential aspects of anger responsivity as revealed by the check for differences in attributional style. No significant intergroup differences were found in participants’ responses to realistic situations (termed vignettes), in evaluation of the anger/provocation inherent in the situation, in the reasons attributed to the “frustrater,” or in self-reported intended response. Implications for future sport research on emo.
Reflective Practice through Journal Writing and Peer Observation: A Case Study.

Journal writing and Peer Observation in an educational context have become popular techniques, with several different types of applications. They have now been used quite widely in both language teaching and in teacher training. However, despite its reported advantages in both teaching and research, there are not many Peer Observation and Diary studies available based on the writing of experienced language teachers. The Teacher participants maintain Journal writing and Peer Observation as a means of reflective practice. They consider these practices as a mirror, which reflects the teacher’s own image as a practioner. The post-reflection discussion reveals that the teacher participants believe in reflective practice as an effective means of self-evaluation and of developing sensitivity to students’ learning. This paper examines Peer Observation and journal writing of two teachers working on the same language programme in terms of a variety of topic headings, and suggests that reflective practice can be a useful tool for both classroom research and teachers’ professional development.
Phenotypic Diagnosis of Lineage and Differentiation During Sake Yeast Breeding

Sake yeast was developed exclusively in Japan. Its diversification during breeding remains largely uncharacterized. To evaluate the breeding processes of the sake lineage, we thoroughly investigated the phenotypes and differentiation of 27 sake yeast strains using high-dimensional, single-cell, morphological phenotyping. Although the genetic diversity of the sake yeast lineage is relatively low, its morphological diversity has expanded substantially compared to that of the Saccharomyces cerevisiae species as a whole. Evaluation of the different types of breeding processes showed that the generation of hybrids (crossbreeding) has more profound effects on cell morphology than the isolation of mutants (mutation breeding). Analysis of phenotypic robustness revealed that some sake yeast strains are more morphologically heterogeneous, possibly due to impairment of cellular network hubs. This study provides a new perspective for studying yeast breeding genetics and micro-organism breeding strategies.
An analysis of femoral component stem design in total hip arthroplasty.

UNLABELLED A comparative study of the various aspects of the design of the femoral components of total hip replacements was done using three-dimensional finite-element stress analysis. The aspects of deisgn that were considered included: length, cross-sectional size, and material properties of the stem; presence or absence of a medial collar; and material properties of the cement. We found that increasing the length of the stem generally increased the stress present in the stem while decreasing the stress present in the cement. Increasing the cross-sectional size of the stem decreased the stress in both the stem and the cement. Decreasing the modulus of elasticity of the stem material decreased the stress in the stem but increased the stress in the cement. Increasing the modulus of elasticity of the cement decreased the stress in the stem and increased the stress in the cement. Contact of the collar of a femoral prosthesis with the calcar femorale increased the longitudinal component of stress within the region of the calcar femorale. CLINICAL RELEVANCE The mechanical longevity of a total joint reconstruction is related to the stress distribution throughout the prosthesis, cement, and bone. The stress distribution is related to a number of factors, including the design of the prosthetic components (for example, stem size, stem length, stem modulus of elasticity, and cement modulus of elasticity). Reducing the stresses in prosthetic components to minimize the risk of failure can be accomplished only through systematic analysis of all components of the reconstruction.
Beliefs About Emotion: Links to Emotion Regulation, Well-Being, and Psychological Distress

People differ in their implicit beliefs about emotions. Some believe emotions are fixed (entity theorists), whereas others believe that everyone can learn to change their emotions (incremental theorists). We extend the prior literature by demonstrating (a) entity beliefs are associated with lower well-being and increased psychological distress, (b) people's beliefs about their own emotions explain greater unique variance than their beliefs about emotions in general, and (3) implicit beliefs are linked with well-being/distress via cognitive reappraisal. These results suggest people's implicit beliefs—particularly about their own emotions—may predispose them toward emotion regulation strategies that have important consequences for psychological health.
Null genotypes at the GSTM1 and GSTT1 genes and the risk of benign prostatic hyperplasia: A case–control study and a meta‐analysis

Benign prostatic hyperplasia (BPH) is an age related non‐malignant disease diagnosed as lower urinary tract symptoms and prostatic enlargement. Null genotypes in drug detoxification glutathione‐S‐transferase genes/enzymes, such as GSTT1 and GSTM1 have been reported to increase risk of several cancers including prostate. Meta‐analysis on PC also suggested significant impact of GSTM1 null genotype but not that of GSTT1; however, BPH data have not been subjected to meta‐analysis.
RNA Processing and Degradation in Bacillus subtilis

SUMMARY This review focuses on the enzymes and pathways of RNA processing and degradation in Bacillus subtilis, and compares them to those of its gram-negative counterpart, Escherichia coli. A comparison of the genomes from the two organisms reveals that B. subtilis has a very different selection of RNases available for RNA maturation. Of 17 characterized ribonuclease activities thus far identified in E. coli and B. subtilis, only 6 are shared, 3 exoribonucleases and 3 endoribonucleases. Some enzymes essential for cell viability in E. coli, such as RNase E and oligoribonuclease, do not have homologs in B. subtilis, and of those enzymes in common, some combinations are essential in one organism but not in the other. The degradation pathways and transcript half-lives have been examined to various degrees for a dozen or so B. subtilis mRNAs. The determinants of mRNA stability have been characterized for a number of these and point to a fundamentally different process in the initiation of mRNA decay. While RNase E binds to the 5′ end and catalyzes the rate-limiting cleavage of the majority of E. coli RNAs by looping to internal sites, the equivalent nuclease in B. subtilis, although not yet identified, is predicted to scan or track from the 5′ end. RNase E can also access cleavage sites directly, albeit less efficiently, while the enzyme responsible for initiating the decay of B. subtilis mRNAs appears incapable of direct entry. Thus, unlike E. coli, RNAs possessing stable secondary structures or sites for protein or ribosome binding near the 5′ end can have very long half-lives even if the RNA is not protected by translation.
Detecting and Predicting Forecast Breakdowns

We propose a theoretical framework for assessing whether a forecast model estimated over one period can provide good forecasts over a subsequent period. We formalize this idea by defining a forecast breakdown as a situation in which the out-of-sample performance of the model, judged by some loss function, is significantly worse than its in-sample performance. Our framework, which is valid under general conditions, can be used not only to detect past forecast breakdowns but also to predict future ones. We show that main causes of forecast breakdowns are instabilities in the data generating process and relate the properties of our forecast breakdown test to those of existing structural break tests. The main differences are that our test is robust to the presence of unstable regressors and that it has greater power than previous tests to capture systematic forecast errors caused by recurring breaks that are ignored by the forecast model. As a by-product, we show that our results can be applied to forecast rationality tests and provide the appropriate asymptotic variance estimator that corrects the size distortions of previous forecast rationality tests. The empirical application finds evidence of a forecast breakdown in the Phillipsi curve forecasts of U.S. inflation, and links it to inflation volatility and to changes in the monetary policy reaction function of the Fed.
Altered skin blood perfusion in areas with non blanchable erythema: an explorative study

Non blanchable erythema, i.e. stage I pressure ulcer, is common in patients in acute and geriatric care and in nursing homes. Research has shown that this type of lesions is prone to develop into more severe pressure ulcers. The peripheral skin blood perfusion is of major importance for the development of pressure ulcers. The aim of this study was to explore the peripheral skin blood perfusion over time, in areas with non blanchable erythema and in corresponding undamaged areas on the opposite side of the body. A total of 19 measurements were performed, over time, using a laser Doppler perfusion imager. The blood flow distribution profiles over areas with non blanchable erythema and undamaged skin were found to be different. As the area of the non blanchable erythema decreased, the blood perfusion distribution profiles gradually became more heterogeneous; an area of high blood perfusion in the centre of the lesions was seen and the perfusion successively decreased closer to the edge. These results indicate that there are differences in blood perfusion between skin areas of non blanchable erythema and undamaged skin. The results also indicate that the visible redness in areas with non blanchable erythema is related to altered blood perfusion. The skin blood perfusion also seems to increase in relation to the size of the non blanchable erythema.
Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis

Significance The exocyst complex is a conserved protein complex that tethers the secretory vesicles to the site of membrane fusion during exocytosis, an essential cellular process that transports molecules, such as protein, to the cell surface or extracellular space. We identified a small molecule that targets the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex to inhibit exocytosis. This compound made it possible to control the dynamics of the exocytosis process in a dosage-dependent manner in different organisms and overcame the mutant lethality and genetic redundancy issues in studying mechanisms of exocyst complex regulation. Further design of molecules with higher affinity and more potent activity may make it possible to use drugs to control human diseases related to exocytosis, such as cancer and diabetes. The exocyst complex regulates the last steps of exocytosis, which is essential to organisms across kingdoms. In humans, its dysfunction is correlated with several significant diseases, such as diabetes and cancer progression. Investigation of the dynamic regulation of the evolutionarily conserved exocyst-related processes using mutants in genetically tractable organisms such as Arabidopsis thaliana is limited by the lethality or the severity of phenotypes. We discovered that the small molecule Endosidin2 (ES2) binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex, resulting in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking. An EXO70 protein with a C-terminal truncation results in dominant ES2 resistance, uncovering possible distinct regulatory roles for the N terminus of the protein. This study not only provides a valuable tool in studying exocytosis regulation but also offers a potentially new target for drugs aimed at addressing human disease.
Duration of a maximal isometric muscular contraction.

Abstract The maximum force exerted by forearm flexors, during isometric contraction at 60, 100 and 120 degrees at the elbow joint, was measured on nine male subjects by means of an electric dynamometer. The intensity of the effort was recorded in ft-lb. of torque to make measurements independent of the length of the forearm. The maximum force was reached on the average in 2.6 sec. (range .6–6.7 sec.) and lasted . 7 sec. (range .2–2.4 sec.). The torque was from 19% to 25.7% greater when an elbow support was used. A sustained contraction was maintained from 2.9 to 8.6 sec. ; thus if no sensitive instrument for recording the intensity of contraction is used, a sustained submaximal contraction may be mistaken for a maximal one.
9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner

Single nucleotide polymorphisms from the chromosome locus 9p21 are reported to carry a risk for various cardiovascular diseases. One of the lead single nucleotide polymorphisms, rs10757278, was mostly investigated in association with coronary artery disease but rarely with carotid atherosclerosis. In this study, we aimed to analyze the association of rs10757278 A/G polymorphism with carotid plaque presence in advanced carotid atherosclerosis. The study included 803 participants, 486 patients with high-grade stenosis (>70%) who were undergoing carotid endarterectomy and 317 controls from Serbian population. Genotypes were determined using the real-time polymerase chain reaction. According to the recessive model of inheritance, GG genotype was significantly and independently associated with carotid plaque in females only (odds ratio 2.42, CI = 1.20–4.90, P = 0.013). Odds ratio was adjusted for age, body mass index, hypertension, TC, LDLC, HDLC and TG, and P value was corrected for multiple comparisons. Our preliminary findings suggest a gender-specific association of rs10757278 polymorphism with carotid plaque. Further studies on larger sample and in genetically and environmentally similar populations are needed.
Vitacyte collagenase HA: a novel enzyme blend for efficient human islet isolation.

Islet transplantation has found its niche in diabetes treatment. It has contributed to a better quality of life and better glycemic control of patients with diabetes suffering from severe hypoglycemia that are not eligible for vascularized pancreas transplantation. Islet isolation is a technically challenging procedure. The different studies within this doctoral thesis aim to improve and standardize different steps in the isolation procedure. They are in particular looking to improve human pancreas preservation during cold storage, to optimize islet release from the exocrine tissue and to assess whether the isolated islet yield can be predicted from a biopsy. We found that pancreas preservation with pre-oxygenated perfluorodecalin (two-layer method) did not improve the ischemic tolerance of the human pancreas as compared to cold storage with the University of Wisconsin (UW) solution. Furthermore, in pancreas with long cold ischemia time (CIT) (>10 hours), Histidine-Tryptophan-Ketoglutarate (HTK) had a limited preservation capacity as compared with the UW solution with respect to isolation outcome. We also found that during enzymatic pancreas digestion, Vitacyte HA was able to provide a similar islet yield and quality as Serva NB1 with less collagenase activity and shorter digestion time. We further describe the first experience with a new GMP manufactured enzyme called Liberase MTF-S for successful human islet isolation. Finally, we found that the isolated islet yield could not be predicted from a biopsy taken from the head of the pancreas concerning solely morphological parameters of the islets tissue. The improvement of pancreas preservation will allow for marginal organs with prolonged cold ischemia time to expand the donor pool. Better knowledge of how the pancreatic extracellular matrix is digested by collagenase will lead to a fast and predictable islet release from the exocrine tissue. By standardizing the isolation procedure and improving organ selection we will increase the success rate in human islet isolation, thereby making islet transplantation available for more patients.
Echocardiographic changes in heart size in hypohydrated horses.

BACKGROUND Hypohydration causes transient echocardiographic changes in pigs, dogs, humans, and cats. These changes mask the diagnosis of some cardiac diseases (valvular regurgitation, dilated cardiomyopathy) and promote the diagnosis of others (hypertropic cardiomyopathy and infiltrative disease), thus inhibiting accurate echocardiographic evaluation. OBJECTIVES To describe the echocardiographic changes associated with hypohydration in normal horses. ANIMALS Ten adult horses without detectable cardiac disease. METHODS Experimental study. Echocardiographic examinations were performed on horses in the euhydrated and hypohydrated states. Horses were hypohydrated by combined water deprivation and furosemide administration until a 4-7% reduction in bodyweight was achieved. Statistical analyses were performed by paired t-tests. RESULTS Hypohydration decreased left ventricular internal diameter in systole (0.8 ± 0.6 cm) and diastole (1.7 ± 0.9 cm), left atrial diameter (1.5 ± 0.4 cm) and left ventricular volume (490 ± 251 mL) (P-values < .01), and increased septal wall thickness in diastole (0.6 ± 0.3 cm), free wall thickness in diastole (0.5 ± 0.3 cm), mean wall thickness (0.5 ± 0.2 cm) and relative wall thickness (0.2 ± 0.1 cm) (P-values < .01). CONCLUSIONS AND CLINICAL IMPORTANCE Hypohydration produces changes in left ventricular and atrial size that could mask or promote the severity of cardiac disease. The thickened, "pseudohypertrophied" appearance of the left ventricle in hypohydrated horses could affect interpretation of echocardiographic variables that are applied to the prediction of athletic performance. Echocardiography may prove a noninvasive method of monitoring volume status and response to fluid therapy in hypovolemic horses.
Low-Latency, Small-Area FPGA Implementation of the Advanced Encryption Standard Algorithm

This paper presents a Field-Programmable Gate Array (FPGA) implementation of an Advanced Encryption Standard (AES) algorithm using approach of combination iterative looping and Look-Up Table (LUT)-based S-box with block and key size of 128 bits. Modifications in the way of loading data out in AES encryption/decryption, loading key_expansion in Key_Expansion blocks are also proposed. The design is tested with the sample vectors provided by Federal Information Processing Standard (FIPS) 197. The design is implemented on APEX20KC Alteraâ€™s FPGA and on Virtex XCV600 Xilinxâ€™s FPGA. For all the authorsâ€™ proposals, they are found to be very simple in FPGA-based architecture implementation, better in low latency, and small area, but large in memory, moderate throughput.
EPICURE: Spatial and Knowledge Limitations in Group Foraging

We propose an agent-based model of group foraging, EPICURE, for patchily distributed resources. Each agent makes probabilistic movement decisions in a gridworld through a linear combination of cur rent perceptual information and a reinforcement history. EPICURE captures the empirical results from several foraging conditions in previous works, and it leads to a reevaluation of findings from those papers. In particular, human foragers show contingent usage of information, initially using social infor mation to discover resource pools before private sampling information has been established. We describe a series of simulations that test the sources of resource undermatching often found in group foraging experiments. After testing the effects of foragers' starting locations, travel costs, the number of foragers, and the size of uniform food distributions, we discuss a novel hypothesis for undermatch ing. Spatial constraints lead to inadequate individual and group information sampling and cause group undermatching. The foraging group size, food rate, spatial distribution of food, and resulting forager reinforcement histories interact to produce undermatching, and occasionally overmatching, to resources.