Miracle-dz/UniFAR-FTUs huggingface dataset:
Handedness genetics: considering the phenotype

The question which genetic, epigenetic and environmental factors contribute to human handedness certainly is one of the central questions in research on manual asymmetries. A number of environmental factors such as season of birth (Stoyanov et al., 2011), cultural influences (Fagard and Dahmen, 2004), differential visual experience of the hands (Ocklenburg and Gunturkun, 2009; Ocklenburg et al., 2010), parental influence (Laland, 2008) and others (Schaafsma et al., 2009) have been shown to influence handedness. Moreover, several genes such as LRRTM1 (Francks et al., 2007), PCSK6 (Scerri et al., 2011; Arning et al., 2013), and AR (Medland et al., 2005; Hampson and Sankar, 2012) have been related to handedness. However, the variance in individual handedness explained by any single one of these factors is typically low, and it is not uncommon that findings in one sample cannot be replicated in others (for example see: Bloss et al., 2010; Hubacek et al., 2013). Furthermore, hardly anything is known about epigenetic and epistatic interactions between different genetic and environmental factors influencing handedness. In view of this, several authors recently argued that only a complex multifactorial model could explain the ontogenesis of handedness (e.g., McManus et al., 2013; Ocklenburg et al., 2013; Armour et al., 2014). McManus et al. (2013) estimated the number of genetic loci involved in handedness to be at least 30–40, and possibly much larger. This estimation suggests that genome-wide association studies with very large sample sizes might constitute a meaningful methodological tool to further advance our knowledge about how handedness develops. In our opinion, however, the large number of involved ontogenetic factors and likely complex interactions between them is only part of the problem why the search for the biological determinants involved in the development of handedness despite continuous research still is at a very early stage.
Distributional Effects of Growth and the Elasticity of Substitution

Reforms that promote economic growth have also an impact on the distribution of capital and income. I consider the effect of a rise in the elasticity of substitution between capital and labor and understand it as liberalization. To evaluate its effects, the normalized CES functions by Klump and de La Grandville (2000) are introduced. A rise in the elasticity of substitution may have an immediate impact on wages. Dynamic effects are studied in the Ramsey model with heterogenous agents by Caselli and Ventura (2000). The existence of a trade-off between growth and equality in liberalizing the economy depends crucially on the choice of the point of normalization. Inequality tends to increase, if an initially low economic flexibility is combined with a high share of capital income, high risk aversion or a wage rate close to the subsistence level. While inequality in a liberalized economy may be higher in the long-term, increases in absolute poverty are compensated quickly.
CDK2-dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression

Although several studies have suggested that the functions of heterochromatin regulators may be regulated by post-translational modifications during cell cycle progression, regulation of the histone methyltransferase Suv39H1 is not fully understood. Here, we demonstrate a direct link between Suv39H1 phosphorylation and cell cycle progression. We show that CDK2 phosphorylates Suv39H1 at Ser391 and these phosphorylation levels oscillate during the cell cycle, peaking at S phase and maintained during S-G2-M phase. The CDK2-mediated phosphorylation of Suv39H1 at Ser391 results in preferential dissociation from chromatin. Furthermore, phosphorylation-mediated dissociation of Suv39H1 from chromatin causes an enhanced occupancy of JMJD2A histone demethylase on heterochromatin and alterations in inactive histone marks. Overexpression of phospho-mimic Suv39H1 induces early replication of heterochromatin, suggesting the importance of Suv39H1 phosphorylation in the replication of heterochromatin. Moreover, overexpression of phospho-defective Suv39H1 caused altered replication timing of heterochromatin and increases sensitivity to replication stress. Collectively, our data suggest that phosphorylation-mediated modulation of Suv39H1-chromatin association may be an initial step in heterochromatin replication.
Soil fertility status and NuMaSS fertilizer recommendation of typic hapluusterts in the northern highlands of Ethiopia.

Nutrient depletion is one of the major causes that contribute to decline in soil productivity in the highlands of Ethiopia. It is generally a reversible constraint as long as soil test based fertilizer application is in place. However, Ethiopian subsistence agriculture has suffered for years due to lack of proper knowledge to combat nutrient depletion. To date, blanket application is the traditional approach for applying commercial fertilizers irrespective of soil types and agroecology. Thus, it is imperative to start to develop an agro-ecology based soil test program for small holding farmers. This study assesses the soil fertility status of Typic Hapluusterts and suggests application of NuMaSS as a diagnostic tool to recommend supplementary N and P fertilizers for maize at limiting sites. In total thirty-six soil samples were collected from five profiles and analyzed for the major soil physical and chemical properties. The study reveals that N, P and micronutrients are deficient in all the sampled profiles. Based on the soil analytical data and farmers' soil fertility management practices, the study proposes that a quarter, half or the lower confident limit of the NuMaSS prescribed fertilizer 213 kg P ha and 104 kg N ha for Adigudom; 161 kg P ha and 98 kg N ha for Adwa; 132 kg P ha and 1 1 11 1
Stochastic Mortality, Subjective Survival Expectations, and Individual Saving Behavior

Theoretical studies suggest that unexpected changes in future mortality and survival probabilities (stochastic mortality) are important determinants of individualsâ€™ decisions about consumption, saving, asset allocation, and retirement timing. Using data on subjective survival expectations elicited in the Survey of Health, Ageing and Retirement in Europe (SHARE) and corresponding life table data from the Human Mortality Database (HMD), we find evidence of respondentsâ€™ awareness of stochastic mortality. We also find that respondentsâ€™ saving behavior is influenced by stochastic mortality perceptions.
Performance and persistence of performance of healthcare mutual funds

This study analyzes 115 actively managed domestic healthcare mutual funds over the period 1/2000 –12/2011. Findings of this study show that, on average, healthcare mutual funds outperform the passive index by roughly 2.97% per year after controlling for the market risk premium, growth and size premiums, and momentum effects. Further, this study documents that the abnormal over- and under-performance does not persist over subsequent periods. In other words, under- and over- performances are mean reverting.
An Investigation Into the Relative Price of Investment

In this thesis, I examine the conventional assumption of identifying investmentspecific technology by the inverse of the relative price of investment. Linking prices to technology in this fashion implies that the relative price is orthogonal to any other form of economic disturbance. However, recent research has found that both neutral technology and the relative price of investment are cointegrated in the postwar US. In the chapters that follow, I explore the impact of this identification by either linking the relative price of investment to total factor productivity, or by allowing this relative price to vary depending on investment demand. In all three chapters, I find that loosening this restriction has a sizable effect on the outcome of my research as it compares to the current literature. In the second chapter, I investigate the effects of incorporating financial frictions into a two-country, two-good international business cycle model. The model is set up such that any changes in the relative price of investment arise endogenously. We find that the relative price of investment is positively correlated across countries in our model, much as it is in detrended US-Europe data. We also find that financial frictions tend to increase the volatility of the terms of trade and raise the international correlations of consumption, hours worked, output and investment.
Pro-Social Behavior In Rats Requires An Affective Motivation

43 words; Manuscript: 9000 words Number of figures: 7; Supplementary material: 5 Current addresses: IBAB: 188 Li Ka Shing Center, Berkeley CA 94720 TMM: Washington University Department of Anesthesiology, 660 S Euclid Avenue, Box 8054, St Louis MO 63110; JZW: Byers Hall; 1700 4th Street; San Francisco, CA 94158-2330 . CC-BY-NC 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not . http://dx.doi. org/10.1101/044180 doi: bioRxiv preprint first posted online Mar. 17, 2016;
Transparency, holophrasting, and automatic layout applied to control structures for visual dataflow programming languages

Control flow within dataflow visual programming languages such as Prograph is difficult to understand due to hidden dependencies created by the control structures that desperate code blocks into independent views. We have created a model arising from research on ReactoGraph -- a derivative of Prograph -- that allows code in a general class of dataflow programming languages to be controlled based on nested graph structures. These structures, aimed at removing hidden dependencies, provide a reasonable alternative to Prograph's case control structures. However, they have also been found to introduce some usability problems such as low tolerance to code layout modification and difficulties scaling the number of code elements as nesting depth increases. In this paper we present a novel use of various software visualization techniques applied to these nested control structures in order to enable effective modification and scalability of code for improved comprehension and programming performance.
Facebook Groups: Perception and Usage among Undergraduates in the Context of Learning

This study presents and evaluates the educational potentials and benefits that Social Network Services (SNSs) offer to students in the higher education context. Based on Social Learning Theory, we explored students’ perception and learning activities in Facebook Groups (i.e. Facebook Learning Groups), and the learning and affective benefits that SNSs offer to students. We further explored the influence of four attributes (i.e. self-efficacy, trust, privacy and presence of teaching members) in moderating individuals’ perception and learning activities on SNSs. Results from a survey accompanied by data collected from a Facebook Learning Group demonstrate the usefulness of these learning groups. Findings also indicate that trust and presence of teaching members do play influential roles in affecting students’ perception and usage of Facebook Learning Groups.
Effects of anti-Ia sera on mitogenic responses. III. Mapping the genes controlling the expression of Ia determinants on concanavalin A- reactive cells to the I-J subregion of the H-2 gene complex

We have shown that the Ia determinants expressed on nylon wool-purified T lymphocytes reactive to concanavalin A (Con A) in serum-free media are coded in a single I subregion of the H-2 gene complex. This region, I-J, is defined by two pairs of intra-H-2 recombinant haplotypes: H- 2t3, H-2t4 and H-2i3, H-2i5, carried by B10.HTT, B10.S(9R), B10.A(3R), AND B10.A(5R), respectively. No activity against Con A-reactive T cells has been detected in any antiserum that was produced in strain combinations which shared a common I-J region. This suggests that Ia antigens expressed on Con A-reactive T cells are restricted to the I-J subregion.
Evaluation of Cognitive and Behavioral Effects of Peer Education Model-Based Intervention to Sun Safe in Children

Abstract Background There have been many studies that evidence the health hazards of sunlight exposure, but less study on sun safe intervention model, especially in China. Our aim was to evaluate the cognitive and behavioral effects of a peer education model-based intervention to sun safe in children. Methods Cluster random control intervention was conducted in one district in Chongqing, China. Two primary schools, selected through stratified clustered sampling approach (two grades in each school, three classes in each grade) were designated as intervention (n=304) and control schools (n=305) randomly. 36 students, selected as peer educators in intervention group, were trained for one month. Educational activities such as discussions were organized by peer educator for one month. There was no sun safe education to participants in control school during the project period. The evaluation of changes of sun safe knowledge (the primary outcome), attitude and behavior (the secondary outcome measures) were conducted before intervention and at months of 0, 1 and 6 of the intervention to two groups using quantitative and qualitative methods. Results After the intervention, sun safe knowledge score which gained by the students from intervention group has been remarkably improved, compared to baseline survey (24.48±6.17 vs. 29.51±6.75) (P<0.001), and it kept this high level (29.02±7.96 and. 28.65±8.96), while control group students' scores have made no difference (P=0.410). Most of students have changed their sun safe behavior after the intervention. Conclusion Peer education program is somewhat effective in some dimensions for improving children's understanding of sun safe knowledge and behavior.
Prevalence of self-injury performed by adolescents aged 16-19 years.

OBJECTIVES The aim of the study was to assess the prevalence of self-injury among adolescents aged 16-19 years and to indicate demographic variable, selected environmental variables and risky behaviours coexisting with performing self-injuries by the respondents. METHODS The research encompassed 5,685 individuals, aged 16-19 years. During the research the Questionnaire designed by the authors was used. RESULTS Significant statistical differences were found between the number of adolescents performing self-injury and those who do not perform it, who use psychoactive agents, make suicide attempts, get drunk, run away from home, report conflicts with their parents, experience parental violence and peer violence and report alcohol addictions by family members. CONCLUSIONS 1. Self-injury is performed by 14% of adolescents aged 16-19 years, significantly more girls than boys. 2. Significantly more adolescents who perform self-injury, as compared to those who do not do it, use psychoactive substances, get drunk, report planning suicide, neglect school and more often consume alcohol. 3. Significantly more adolescents who perform self-injury, as compared to those who do not perform it, raised in a single parent family inform about alcohol addiction of a family member, conflicts with parents and the experienced psychological and physical violence experienced from their parents and peers. Significantly more girls who perform self-injury, as compared to those who do not perform it, experienced sexual abuse. 4. Performing self-injury by adolescents coexists with factors motivating to this type of behaviours: sense of helplessness, rejection, loneliness, sense of guilt, anger, impulsiveness, desire for revenge, school problems, conflicts with parents and peers.
Mineralocorticoid Receptor Blocker Increases Angiotensin-Converting Enzyme 2 Activity in Congestive Heart Failure Patients

Aldosterone plays an important role in the pathophysiology of congestive heart failure (CHF), and spironolactone improves cardiovascular function and survival rates in patients with CHF. We hypothesized that the mineralocorticoid receptor blockade (MRB) exerted its beneficial effects by reducing oxidative stress and changing the balance between the counter-acting enzymes angiotensin-converting enzyme (ACE) and ACE2. Monocyte-derived macrophages were obtained from 10 patients with CHF before and after 1 month of treatment with spironolactone (25 mg/d). Spironolactone therapy significantly (P<0.005) reduced oxidative stress, as expressed by reduced lipid peroxide content, superoxide ion release, and low-density lipoprotein oxidation by 28%, 53%, and 70%, respectively. Although spironolactone significantly (P<0.01) reduced macrophage ACE activity by 47% and mRNA expression by 53%, ACE2 activity and mRNA expression increased by 300% and 654%, respectively. In mice treated for 2 weeks with eplerenone (200 mg · kg−1 · d−1), cardiac ACE2 activity significantly (P<0.05) increased by 2-fold and was paralleled by increased ACE2 activity in macrophages. The mechanism of aldosterone antagonist action was studied in mouse peritoneal macrophages (MPMs) in vitro. Although ACE activity and mRNA were significantly increased by 250 nmol/L aldosterone, ACE2 was significantly reduced. Cotreatment with eplerenone (2 &mgr;mol/L) attenuated these effects. In MPM obtained from p47 knockout mice, where NADPH oxidase is inactive, as well as in control MPMs treated with NADPH oxidase inhibitor, aldosterone did not increase ACE or decrease ACE2. MRB reduced oxidative stress, decreased ACE activity, and increased ACE2 activity, suggesting a protective role for MRB by possibly increasing generation of angiotensin (1–7) and decreasing formation of angiotensin II. These effects are mediated, at least in part, by NADPH oxidase.
Please Scroll down for Article Journal of Cultural Economy Reassembling Nuremberg, Reassembling Heritage

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Herding, anti-herding behaviour in metal commodities futures: a novel portfolio-based approach

The purpose of this article is twofold. Motivated by the heated debate on the financialization of commodities, we examine the existence of herding behaviour in metal commodities futures. In order to identify any time-dependent properties reflected in time-varying parameters, we employ the overlapping rolling window regression technique. The empirical evidence confirms a time-varying anti-herding behaviour before the global financial crisis and the absence of herding or anti-herding behaviour during the crisis. Next we attempt to formally establish the link between the documented anti-herding behaviour and portfolio management with the use of dynamic conditional correlations via the DCC-GARCH family multivariate modelling. After specifying the correlations, an in-sample recursive dynamic Markowitz portfolio is constructed and monitored. By doing so, we attribute the anti-herding behaviour to different portfolio positioning and rebalancing. On the other hand, in the absence of herding or anti-herding behaviour, we document a shift in the correlations and covariances of the commodity futures especially during the crisis, resulting in a decrease of the portfolio weights together with a substantial cash flow towards the risk-free asset.
Foreign Aid Volatility and Lifelong Learning: Demand-Side Empirics to a Textual Literature

Purpose- This paper has put a demand-side empirical structure to the hypothesis that foreign aid volatility adversely affects choices to lifelong learning in recipient countries Design/methodology/approach- Lifelong learning is measured as the combined knowledge acquired during primary, secondary and tertiary educational enrolments. Three types of aggregate foreign aid volatilities are computed in a twofold manner: baseline standard deviations and standard errors (standard deviations of residuals after first-order autoregressive processes). An endogeneity robust dynamic system GMM empirical strategy is employed. Findings- The findings broadly show that foreign aid volatility does not adversely affect the demand-side choices of lifelong learning in Africa. Practical implications- As a policy implication, when faced with aid uncertainty, the demand for education would increase. This may be explained by the need for more self-reliance in order to mitigate income risks or/and the use of education as means of copping with uncertainty. Moreover, the findings indirectly confirm a stream of the literature sustaining that when faced with uncertainty in external financial flows, countries may recourse to promoting human resource development through lifelong learning and knowledge economy as a competitive advantage. This may also explain why countries which have acknowledged scarcity in external financial flows from natural resources have done relatively better compared to their natural resource-rich counterparts. Originality/value- This paper has provided demand-side empirics to a hypothesis that could substantial influence policy making.
Electrosense: Open and Big Spectrum Data

While radio spectrum allocation is well regulated, there is little knowledge about its actual utilization over time and space. This limitation hinders taking effective actions in various applications including cognitive radios, electrosmog monitoring, and law enforcement. We introduce Electrosense, an initiative that seeks a more efficient, safe and reliable monitoring of the electromagnetic space by improving the accessibility of spectrum data for the general public. A collaborative spectrum monitoring network is designed that monitors the spectrum at large scale with low-cost spectrum sensing nodes. The large set of data is stored and processed in a big data architecture and provided back to the community with an open spectrum data as a service model, that allows users to build diverse and novel applications with different requirements. We illustrate useful usage scenarios of the Electrosense data.
Optimal adjuvant therapy for resected hepatocellular carcinoma: a systematic review with network meta-analysis

Objectives Major adjuvant therapies (ATs) for resected hepatocellular carcinoma (HCC) include chemotherapy, internal radiation therapy (IRT), interferon therapy (IFNT) and immunotherapy but the optimum regimen remains inconclusive. We aim to compare these therapies in terms of patient survival and recurrence rates. Methods We searched PubMed, EMBASE and Cochrane library databases for randomized trials comparing the above four therapies until 31 March 2014. We estimated the HRs for survival and ORs for overall recurrence among different therapies. Toxic effects were also evaluated. Results Fourteen eligible articles were included. IFNT improved 5-year survival greatly (HR 1.81, 95% CI 1.01–3.81, P = 0.034), whereas chemotherapy (HR 0.33, 95% CI 0.03–2.02), IRT (HR 0.31, 95% CI 0.02–3.33) and immunotherapy (HR 0.73, 95% CI 0.05–9.12) all provided a poorer survival outcome after 1-year. Similarly, for 5-year survival rates, although differing, IRT did not provide a significant improvement in survival (HR 1.38, 95% CI 0.34–5.19) compared with IFNT. Chemotherapy (HR 0.49, 95% CI 0.18–1.14) and immunotherapy (HR 0.56, 95% CI 0.17–1.59) did not appear to provide benefit over IFNT. Chemotherapy was ranked the worst in overall recurrence (OR 0.99, 95% CI 0.18–5.38) and most likely to cause toxic effects. Conclusions IFNT was the most efficacious AT regimen both for short and long term survivals. Immunotherapy and IFNT were the most two effective in preventing overall relapse for resected HCC.