Miracle-dz/UniFAR-FTUs huggingface dataset:
Replacement reactions and deformation by dissolution and precipitation processes in amphibolites

The deformation of the middle to lower crust in collisional settings occurs via deformation mechanisms that vary with rock composition, fluid content, pressure, and temperature. These mechanisms are responsible for the accommodation of large tectonic transport distances during nappe stacking and exhumation. Here, we show that fracturing and fluid flow triggered coupled dissolution–precipitation and dissolution–precipitation creep processes, which were responsible for the formation of a mylonitic microstructure in amphibolites. This fabric is developed over a crustal thickness >500 m in the Lower Seve Nappe (Scandinavian Caledonides). Amphibolites display a mylonitic foliation that wraps around albite porphyroclasts appearing dark in panchromatic cathodoluminescence (CL). The albite porphyroclasts were dissected and fragmented by fractures preferentially developed along the (001) cleavage planes and display lobate edges with embayments and peninsular features. Two albite/oligoclase generations, bright in CL, resorbed and overgrew the porphyroclasts, sealing the fractures. Electron backscattered diffraction shows that the two albite/oligoclase generations grew both pseudomorphically and topotaxially at the expense of the albite porphyroclasts and epitaxially around them. These two albite/oligoclase generations also grew as neoblasts elongated parallel to the mylonitic foliation. The amphibole crystals experienced a similar microstructural evolution, as evidenced by corroded ferrohornblende cores surrounded by ferrotschermakite rims that preserve the same crystallographic orientation of the cores. Misorientation maps highlight how misorientations in amphibole are related to displacement along fractures perpendicular to its c‐axis. No crystal plasticity is observed in either mineral species. Plagioclase and amphibole display a crystallographic preferred orientation that is the result of topotaxial growth on parental grains and nucleation of new grains with a similar crystallographic orientation. Amphibole and plagioclase thermobarometry constrains the mylonitic foliation development to the epidote amphibolite facies (˜600°C, 0.75–0.97 GPa). Our results demonstrate that at middle to lower crustal levels, the presence of H2O‐rich fluid at grain boundaries facilitates replacement reactions by coupled dissolution–precipitation and favours deformation by dissolution–precipitation creep over dislocation creep in plagioclase and amphibole.
Response to Comment on "Pierolapithecus catalaunicus, a New Middle Miocene Great Ape from Spain"

We describe a partial skeleton with facial cranium of Pierolapithecus catalaunicus gen. et sp. nov., a new Middle Miocene (12.5 to 13 million years ago) ape from Barranc de Can Vila 1 (Barcelona, Spain). It is the first known individual of this age that combines well-preserved cranial, dental, and postcranial material. The thorax, lumbar region, and wrist provide evidence of modern ape-like orthograde body design, and the facial morphology includes the basic derived great ape features. The new skeleton reveals that early great apes retained primitive monkeylike characters associated with a derived body structure that permits upright postures of the trunk. Pierolapithecus, hence, does not fit the theoretical model that predicts that all characters shared by extant great apes were present in their last common ancestor, but instead points to a large amount of homoplasy in ape evolution. The overall pattern suggests that Pierolapithecus is probably close to the last common ancestor of great apes and humans.
Growth Inhibition by Nitrocompounds of Selected Uric Acid-Utilizing Microorganisms Isolated from Poultry Manure

The overall objective of this study was to evaluate the potential ability of nitrocompounds to reduce ammonia volatilization by inhibiting uric acid–utilizing microorganisms. Experiment I was conducted to evaluate the effects of nitrocompounds on the growth of uric acid–utilizing microorganisms isolated from poultry manure during six-hour incubation. There were five treatments: (1) control, (2) 50 mM nitroethane, (3) 50 mM nitroethanol, (4) 50 mM nitropropanol, and (5) 50 mM nitropropionic acid. Optical density values of nitrocompounds were significantly lower than that of control at two, four, and six hours. Plate counts of uric acid–utilizing microorganisms after six-hour incubation exhibited that nitrocompounds greatly reduced the growth of these microorganisms except for the nitroethane (P < 0.05). The nitropropanol and nitropropionic acid treatments showed significantly higher inhibitory effects compared to the nitroethanol. Experiments II and III were conducted to evaluate inhibitory effects of nitrocompounds on growth of uric acid–utilizing microorganisms compared to non-nitrocompounds such as ethanol, propanol, and propionic acid. Experiments II and III consisted of seven treatments: (1) control, (2) nitroethanol, (3) nitropropanol, (4) nitropropionic acid, (5) ethanol, (6) propanol, and (7) propionic acid. The incubation times of Experiments II and III were 6 and 24 h, respectively. The nitrocompounds were significantly more successful in inhibiting growth of uric acid–utilizing microorganisms compared to those non-nitrocompounds. These results suggest that nitrocompounds exhibit potential to reduce ammonia volatilization in poultry manure by inhibiting growth of uric acid–utilizing microorganisms.
Stimulus Dependence of Neuronal Correlation in Primary Visual Cortex of the Macaque

Nearby cortical neurons often have correlated trial-to-trial response variability, and a significant fraction of their spikes occur synchronously. These two forms of correlation are both believed to arise from common synaptic input, but the origin of this input is unclear. We investigated the source of correlated responsivity by recording from pairs of single neurons in primary visual cortex of anesthetized macaque monkeys and comparing correlated variability and synchrony for spontaneous activity and activity evoked by stimuli of different orientations and contrasts. These two stimulus manipulations would be expected to have different effects on the cortical pool providing input to the recorded pair: changing stimulus orientation should recruit different populations of cells, whereas changing stimulus contrast affects primarily the relative strength of sensory drive and ongoing cortical activity. Consistent with this predicted difference, we found that correlation was affected by these stimulus manipulations in different ways. Synchrony was significantly stronger for orientations that drove both neurons well than for those that did not, but correlation on longer time scales was orientation independent. Reducing stimulus contrast resulted in a decrease in the temporal precision of synchronous firing and an enhancement of correlated response variability on longer time scales. Our results thus suggest that correlated responsivity arises from mechanisms operating at two distinct timescales: one that is orientation tuned and that determines the strength of temporally precise synchrony, and a second that is contrast sensitive, of low temporal frequency, and present in ongoing cortical activity.
Drug utilization and polypharmacy among the elderly: a survey in Rio de Janeiro City, Brazil.

OBJECTIVES To describe drug utilization by Brazilian retirees with an emphasis on inappropriate use. METHODS Cross-sectional study with a simple random sample of 800 retirees of the Brazilian Institute of Social Security, 60 years of age and older, residing in Rio de Janeiro City, through face-to-face interviews. RESULTS Medication use in the 15 days before the study was reported by 85% of the sample, with a mean of 3.7 products per person (standard deviation=2.9). About half the sample used one to four medications and a third used five or more. The highest number of drugs used per patient was 24. More women than men used multiple medications. There is a tendency toward positive association (P<0.001) between drug use and variables relating to disease and health care. This trend continues in the analysis by gender. Men who reported five or more diseases were five times more likely to use multiple drugs than men with up to two (zero, one, or two) diseases (prevalence ratio 5.21, 95% confidence interval=2.48-10.90). Women who reported five or more diseases were nearly four times more likely to use multiple drugs than women with up to two diseases (prevalence ratio 3.67, 95% confidence interval=2.24-6.02). Of the active substances used by the sample, 10% were considered inappropriate. CONCLUSIONS To improve drug therapy for the elderly, health practitioners can take measures to reduce unwarranted use of medication and to optimize the benefits from important drugs. Further studies should be conducted to adjust lists of medications inappropriate for the elderly to the situation in developing countries.
Petrography and Mineralogy of Amphibolite Rocks in Penjween Complex, Northeastern Iraq

— Penjween igneous complex is situated in the northeastern part of the Iraqi Zagros Thrust Zone (IZTZ) which is considered as integral part of the Alpine-Himalayan Orogenic Belt of Cretaceous age. The amphibolite rocks exist in Penjween as pods of lensoid-shape of variable sizes (2-3m). These amphibolite pods are surrounded by sheared tectonized serpentinite and peridotite and one is in contact with amphibole-bearing gabbro dike. In addition, there is an albitite dyke in contact with the amphibolite. These amphibolites exhibit deformation and alteration which is evident by the existence of chlorite veins cutting through or as patches within these rocks. Petrographic observations reveal that the main mineral constituents are amphibole; both primary and secondary, plagioclase with accessory clinopyroxene, quartz, titanite, apatite, zircon and iron oxides. Secondary minerals include chlorite, epidote, secondary amphibole and iron oxides as a consequence of alteration. Dominated textures are porphyroblastic, poikiloblastic, nematoblastic , blasto-ophitic and blasto-subophitic which are inherited from the original rocks. Accordingly, two mineral assemblages are identified: 2- Hb. + plag. ± qtz. ± titanite ± apatite ± zircon ± iron oxides ± chl. ± sericite ± ep. The secondary assemblage is more altered. On the basis of Mg/(Mg+Fe)-Si per formula of the analyzed amphibole, two types of amphibole are observed; Mg-hornblende and tschermakite. Chemical analyses of the plagioclase grains give two types; oligoclase (An23.9 Ab75.9 ) and albite (An1.7 Ab97.9).
Expression of intermediate filaments in cultured cells.

The occurrence of different types of intermediate filaments in primary cultures of cells and in cultured cell lines was studied by the indirect immunofluorescence (IFL) technique. The antibodies used were spontaneous monoclonal human antibodies of immunoglobulin M (IgM) class against vimentin-type intermediate filaments (fibroblast 58 x 10 mol. wt subunit protein), and experimental rabbit antibodies of IgG class against vimentin, desmin (muscle 55 x io mol. wt subunit protein), glial fibrillary acidic protein (GFA), 68 x io mol. wt neurofilament polypeptide and human keratin polypeptides. Cultured fibroblasts from different species, and both aortic and venous endothelial cells, showed a fibrillar cytoplasmic fluorescence when stained with antibodies against vimentin. On the other hand, in cultures of chicken embryonal fibroblasts, cells showing a bright desminspecific fluorescence, but lacking vimentin-specific staining, were seen even after several subcultivations. The presence of both desmin and vimentin polypeptides in these cultures was also confirmed by polyacrylamide gel electrophoresis. In chicken fibroblast cultures the 2 types of intermediate filaments were not expressed simultaneously in individual cells, whereas in baby hamster kidney (BHK-21) cells and human rhabdomyosarcoma cells a variable co-staining with anti-vimentin and anti-desmin antibodies could be seen. In contrast, cultured human fibrosarcoma cells and simian virus 40-transformed human fibroblasts showed only vimentinspecific fibrillar fluorescence. Glial cells from mouse embryonic spinal cord appeared to express only GFA-containing intermediate filaments in a primary culture, whereas both subcultured mouse glial cells and a cultured glioma cell-line also showed vimentin-specific staining. On the other hand, neuronelike cells in the primary cultures could only be stained with the antibodies to 68 x io mol. wt neurofilament polypeptide. Interestingly, clones ofmouseneuroblastoma(Ci 300) cells contained
Meiotic Recombination Analyses of Individual Chromosomes in Male Domestic Pigs (Sus scrofa domestica)

For the first time in the domestic pig, meiotic recombination along the 18 porcine autosomes was directly studied by immunolocalization of MLH1 protein. In total, 7,848 synaptonemal complexes from 436 spermatocytes were analyzed, and 13,969 recombination sites were mapped. Individual chromosomes for 113 of the 436 cells (representing 2,034 synaptonemal complexes) were identified by immunostaining and fluorescence in situ hybridization (FISH). The average total length of autosomal synaptonemal complexes per cell was 190.3 µm, with 32.0 recombination sites (crossovers), on average, per cell. The number of crossovers and the lengths of the autosomal synaptonemal complexes showed significant intra- (i.e. between cells) and inter-individual variations. The distributions of recombination sites within each chromosomal category were similar: crossovers in metacentric and submetacentric chromosomes were concentrated in the telomeric regions of the p- and q-arms, whereas two hotspots were located near the centromere and in the telomeric region of acrocentrics. Lack of MLH1 foci was mainly observed in the smaller chromosomes, particularly chromosome 18 (SSC18) and the sex chromosomes. All autosomes displayed positive interference, with a large variability between the chromosomes.
The Role of Hip Muscle Function in the Treatment of Patellofemoral Pain Syndrome

Background Previous literature has associated hip weakness with patellofemoral pain syndrome. Hypothesis Improvements in hip strength and flexibility are associated with a decrease in patellofemoral pain. Study Design Cohort study; Level of evidence, 2. Methods Thirty-five patients with patellofemoral pain syndrome, aged 33 ± 16 years (29 women, 6 men; 43 knees), were evaluated and placed on a 6-week treatment program. Hip flexion, abduction, and adduction strengths, Thomas and Ober test results, and visual analog scale scores for pain with activities of daily living as well as with exercise were documented on initial evaluation and again 6 weeks later. Treatment consisted of strength and flexibility exercises primarily focusing on the hip. Results Hip flexion strength improved by 35% ± 8.4% in 26 lower extremities treated successfully, compared with –1.8% ± 3.5% in 17 lower extremities with an unsuccessful outcome (P< .001). Before treatment, there were positive Ober test results in 39 of 43 lower extremities; positive Thomas test results were seen in 31 of 43 lower extremities. A successful outcome with a concurrent normalized Ober test result was seen in 83% (20/24) of lower extremities, and successful outcomes with normalized Thomas test results were seen in 80% (16/20) of lower extremities. A combination of improved hip flexion strength (> 20%) as well as normal Ober and Thomas test results was seen in 93% of successfully treated cases (14/15 lower extremities), compared with 0% success (0/5 lower extremities) if there was no change in hip flexion strength (< 20%) and if Ober and Thomas test results remained positive. Conclusions Improvements in hip flexion strength combined with increased iliotibial band and iliopsoas flexibility were associated with excellent results in patients with patellofemoral pain syndrome.
Plaque pH in Caries-Free and Caries-Active Young Individuals before and after Frequent Rinses with Sucrose and Urea Solution

Objective: To examine pH in the approximal dental biofilm after acid and alkali formation from sucrose and urea, after an adaptation period to these substances, in caries-free (CF) and caries-active (CA) individuals. Saliva flow and buffer capacity, and aciduric bacteria in saliva and plaque were also examined. Material and Methods: Twenty adolescents and young adults (15-21 years) with no caries (n = 10, Dm + iMFS = 0) or ≥1 new manifest lesions/year (n = 10, DmMFS = 3.4 ± 1.8) participated. After plaque sampling, interproximal plaque pH was measured using the strip method before (baseline) and up to 30 min (final pH) after random distribution of a 1-min rinse with 10 ml of 10% sucrose or 0.25% urea. This procedure was repeated after a 1-week adaptation period of rinsing 5 times/day with 10 ml of the selected solution. After a 2-week washout period the second solution was similarly tested. Mutans streptococci, lactobacilli and pH 5.2-tolerant bacteria were analyzed by culturing. Results: In the CF group, acid adaptation resulted in lowering of baseline and final plaque pH values after a sugar challenge, and in increased numbers of bacteria growing at pH 5.2, which was increased also after alkali adaptation. In the CA group, the final pH was decreased after acid adaptation. No clear effects of alkali adaptation were seen in this group. Conclusion: One-week daily rinses with sucrose and urea had the most pronounced effect on the CF group, resulting in increased plaque acidogenicity from the sugar rinses and increased number of acid-tolerant plaque bacteria from both rinses.
TASTE TRUMPS HEALTH AND SAFETY: INCORPORATING CONSUMER PERCEPTIONS INTO A DISCRETE CHOICE EXPERIMENT FOR MEAT

Abstract Consumers implicitly incorporate their perceptions of products into their decision processes, yet little research has explicitly focused on how those perceptions influence demand for meat. This study incorporates taste, health, and safety perceptions into a discrete choice experiment for meat products at a grocery store. Our results indicate that taste is the most important perception as a 1-unit increase in the perceived tastiness (on a −5 to +5 scale) of a food product leads to a $0.60 increase in willingness to pay, whereas equivalent increases in perceived health and safety lead to $0.31 and $0.21 increases, respectively.
Activation of metabotropic glutamate receptors improves the accuracy of coincidence detection by presynaptic mechanisms in the nucleus laminaris of the chick

• Interaural time difference (ITD) is a major cue for sound source localization and is processed by detecting a coincidence of bilateral excitatory postsynaptic potentials (EPSPs) in the nucleus laminaris (NL) in birds. • The sharpness of coincidence detection (CD) depends on the speed and size of EPSPs. We found here a regulatory mechanism of EPSP size through the presynaptic mGluR activity. • The activation of mGluRs reduced the transmitter release and extent of excitatory postsynaptic current depression during tetanic stimulation, but improved the CD. Furthermore, the activity of mGluRs and their expression were graded along the tonotopic axis and were stronger toward the low frequency neurons of NL. • We proposed an idea that the presynaptic mGluRs may operate as a self‐regulatory mechanism to optimize the size of EPSP and have roles in sharpening the CD. This regulatory mechanism may underlie the sound source localization particularly during a long‐lasting sound in the NL.
Current Status of the Screening of Chlamydia trachomatis Infection Among Japanese Pregnant Women

Chlamydia trachomatis (CT) infection in pregnancy can cause maternal disease, adverse pregnancy outcomes, and neonatal disease [1-6]. In general, approximately 80% of CT infected women are asymptomatic or minimally symptomatic. There-fore, screening is the only means to effectively identify infec-tions [2]. In Japan, pregnant women are routinely tested for CT with the Japanese public funds. According to the guide-lines for obstetrical practice in Japan [7], Japanese obstetri-cians must provide a test for the detection of CT for the pre-vention of neonatal CT infection and diagnose urogenital CT infection when CT is detected using polymerase chain reac-tion (PCR), strand displacement amplification, transcription mediated amplification, an enzyme immunoassay, or culture methods in specimens obtained from the uterine cervix (CT nucleic acid detection tests). However, CT antibody detection by IgA tests has been substituted for these methods by some of obstetricians.On October 2014, we requested 2,544 obstetrical facilities that are members of Japan Association of Obstetricians and Gynecologists (JAOG) to provide information of CT screen-ing tests in pregnant women between October 2013 and March 2014. A total of 1,644 (64.6%) of 2,544 obstetrical facilities responded with possible statistical analysis information on a total of 328,788 women, accounting for approximately 65% of all deliveries that occurred in Japan during the study period. Of the 1,644 obstetrical facilities, CT nucleic acid detection PCR tests, CT nucleic acid detection tests except PCR and CT antibody detection tests were performed in 1,221 (74.3%), 408 (24.8%) and 15 (0.9%) facilities, respectively.Table 1 shows the maternal age distribution under the three CT screening tests (CT nucleic acid detection tests with and without PCR and CT antibody detection tests). There were no significant differences in the maternal age distribution among the three CT screening tests groups.Table 2 shows the results of CT screening tests (CT nucle-ic acid detection tests with and without PCR and CT antibody detection tests) of the study population by age. There were no significant differences in the rate of positive CT between the two groups of CT nucleic acid detection screening tests with and without PCR. However, the positive rate by the CT anti-body detection tests was significantly higher than those by the two CT nucleic acid detection tests with and without PCR (P < 0.01 by X
White Matter Microstructure is Associated with Auditory and Tactile Processing in Children with and without Sensory Processing Disorder

Sensory processing disorders (SPDs) affect up to 16% of school-aged children, and contribute to cognitive and behavioral deficits impacting affected individuals and their families. While sensory processing differences are now widely recognized in children with autism, children with sensory-based dysfunction who do not meet autism criteria based on social communication deficits remain virtually unstudied. In a previous pilot diffusion tensor imaging (DTI) study, we demonstrated that boys with SPD have altered white matter microstructure primarily affecting the posterior cerebral tracts, which subserve sensory processing and integration. This disrupted microstructural integrity, measured as reduced white matter fractional anisotropy (FA), correlated with parent report measures of atypical sensory behavior. In this present study, we investigate white matter microstructure as it relates to tactile and auditory function in depth with a larger, mixed-gender cohort of children 8–12 years of age. We continue to find robust alterations of posterior white matter microstructure in children with SPD relative to typically developing children (TDC), along with more spatially distributed alterations. We find strong correlations of FA with both parent report and direct measures of tactile and auditory processing across children, with the direct assessment measures of tactile and auditory processing showing a stronger and more continuous mapping to the underlying white matter integrity than the corresponding parent report measures. Based on these findings of microstructure as a neural correlate of sensory processing ability, diffusion MRI merits further investigation as a tool to find biomarkers for diagnosis, prognosis and treatment response in children with SPD. To our knowledge, this work is the first to demonstrate associations of directly measured tactile and non-linguistic auditory function with white matter microstructural integrity – not just in children with SPD, but also in TDC.