Miracle-dz/UniFAR-FTUs huggingface dataset:
Deletion of chromosome 1p loci and microsatellite instability in neuroblastomas analyzed with short-tandem repeat polymorphisms.

We have analyzed DNA from 46 neuroblastoma tumors of all clinical stages and five ganglioneuroma tumors together with corresponding control DNA for loss of heterozygosity (LOH) on the distal 1p chromosomal region (1p-LOH). The markers used for the analyses were genetically mapped DNA polymorphisms detectable with PCR analysis. In general, there was concordance among aggressive tumor stage, 1p deletion, and N-myc amplification, although exceptions were found. Twelve (26%) of the 46 neuroblastoma tumors displayed 1p-LOH, 11 being stage 4 and 1 stage 2 (which progressed subsequently to stage 4), whereas 10 stage 4 tumors showed no 1p-LOH. Of 12 neuroblastomas shown to have N-myc amplification, 10 had 1p-LOH. In 8 cases it was possible to test for parental origin of the chromosome involved in 1p-LOH. No significant correlation between LOH and paternal or maternal allele was found. Commonly deleted loci in the distal 1p region in the neuroblastoma tumors indicated that the region for a tentative neuroblastoma tumor suppressor gene is defined proximally by marker D1S244 and distally by marker D1S80. One striking feature of three stage 2 neuroblastomas and one of the stage 3 tumors was the presence in the tumor DNA of alleles not present in the constitutional DNA of the patients, i.e., microsatellite instability. The significance of this phenomenon in localized neuroblastoma tumors remains to be clarified. Aggressive neuroblastoma in young children (younger than 2 years of age) seems to be a homogenous disorder consistently showing concomitant 1p-LOH and N-myc amplification. In the majority of unfavorable neuroblastoma in older children, however, neither 1p-LOH nor N-myc amplification could be detected. This indicates that neuroblastoma in older children is a biologically more heterogenous disorder in which genetic alterations other than deletions of chromosome 1p and amplification of N-myc also may contribute to tumorigenesis.
Ten years of war: A characterization of craniomaxillofacial injuries incurred during operations Enduring Freedom and Iraqi Freedom

BACKGROUND Improved armor and battlefield medicine have led to better survival in the wars in Iraq and Afghanistan than any previous ones. Increased frequency and severity of craniomaxillofacial injuries have been proposed. A comprehensive characterization of the injury pattern sustained during this 10-year period to the craniomaxillofacial region is needed to improve our understanding of these unique injuries, to optimize the treatment for these patients, and to potentially direct strategic development of protective equipment in the future. METHODS The Joint Theater Trauma Registry was queried from October 19, 2001, to March 27, 2011, covering operations Enduring Freedom and Iraqi Freedom for battle injuries to the craniomaxillofacial region, including patient demographics and mechanism of injury. Injuries were classified according to type (wounds, fractures, burns, vascular injuries, and nerve injuries) using DRG International Classification of Diseases—9th Rev. diagnosis codes. RESULTS In this 10-year period, craniomaxillofacial battle injuries to the head and neck were found in 42.2% of patients evacuated out of theater. There is a high preponderance of multiple wounds and open fractures in this region. The primary mechanism of injury involved explosive devices, followed by ballistic trauma. CONCLUSION Modern combat, characterized by blast injuries, results in higher than previously reported incidence of injury to the craniomaxillofacial region. LEVEL OF EVIDENCE Epidemiologic study, level IV.
Metformin versus flutamide in the treatment of metabolic consequences of non-obese young women with polycystic ovary syndrome: a randomized prospective study

In addition to the reproductive consequences, polycystic ovary syndrome (PCOS) is characterized by a metabolic disorder in which hyperinsulinemia and insulin resistance are central features. The effects and possible benefits from insulin-sensitizing drugs are not well known, especially in non-obese women with PCOS. This study was designed to evaluate the effects of metformin and flutamide on metabolic parameters and insulin resistance in non-obese women with PCOS. Thirty non-obese women newly diagnosed with PCOS and 15 age- and weight-matched healthy volunteers as controls were included in the study. Patients were assigned randomly to receive flutamide 250 mg daily or metformin 850 mg three times daily. Glucose, insulin, insulin resistance, androgen levels and glucose and insulin responses to an oral glucose tolerance tests (OGTT) were assessed before and after a 4-week therapy period. A positive correlation was found between body mass index and insulin level in patients with PCOS and controls. Follicle stimulating hormone, luteinizing hormone, free testosterone and dehydroepiandrosterone sulfate levels decreased significantly, but insulin resistance levels were not changed after flutamide therapy. Body weight, free testosterone, insulin and insulin resistance levels decreased significantly after metformin therapy. In conclusion, metformin treatment improved insulin sensitivity and decreased androgen levels, and flutamide decreased androgen levels but failed to improve insulin sensitivity in the non-obese women with PCOS.
Emotional exhaustion and overcommitment to work are differentially associated with hypothalamus–pituitary–adrenal (HPA) axis responses to a low-dose ACTH1–24 (Synacthen) and dexamethasone–CRH test in healthy school teachers

Evidence for a detrimental impact of chronic work stress on health has accumulated in epidemiological research. Recent studies indicate altered hypothalamus–pituitary–adrenal (HPA) axis regulation as a possible biological pathway underlying the link between stress and disease. However, the direction of dysregulation remains unclear, with reported HPA hyper- or hyporeactivity. To disentangle potential effects on different functional levels in the HPA axis, we examined responses using two pharmacological stimulation tests in 53 healthy teachers (31 females, 22 males; mean age: 49.3 years; age range: 30–64 years): a low-dose adrenocorticotrophic hormone (ACTH1–24, Synacthen) test was used to assess adrenal cortex sensitivity and the combined dexamethasone–corticotropin releasing hormone (DEX–CRH) test to examine pituitary and adrenal cortex reactivity. Blood and saliva samples were collected at − 1,+15,+30,+45,+60,+90,+120 min. Emotional exhaustion (EE), the core dimension of burnout, was measured with the Maslach Burnout Inventory. Overcommitment (OC) was assessed according to Siegrist's effort–reward–imbalance model. We found a significant association between EE and higher plasma cortisol profiles after Synacthen (p = 0.045). By contrast, OC was significantly associated with attenuated ACTH (p = 0.045), plasma cortisol (p = 0.005), and salivary cortisol (p = 0.023) concentrations following DEX–CRH. Results support the notion of altered HPA axis regulation in chronically work-stressed teachers, with differential patterns of hyper- and hyporeactivity depending on individual stress condition and the tested functional level of the HPA axis.
Cognitive Dissonance : Neural Correlates and New Theoretical Approaches

Cognitive dissonance has traditionally been defined as the negative affective state which accompanies inconsistent cognitions and motivates one to make the cognitions consistent. This thesis critically evaluates two theories about cognitive dissonance. The action-based model of dissonance argues that inconsistent cognitions have the potential to interfere with effective and unconflicted action. The new look model of dissonance, contradicting the traditional definition of dissonance, argues that it is aversive consequences rather than inconsistent cognitions that cause dissonance. Recent studies investigating the neural correlates of dissonance show that parts of anterior cingulate cortex and prefrontal cortex seem to be involved in the dissonance process. One of the major predictions of the new look model of dissonance has been undermined by recent evidence. In contrast, the action-based model of dissonance is supported by recent studies.
From Group to Individual Labels Using Deep Features

In many classification problems labels are relatively scarce. One context in which this occurs is where we have labels for groups of instances but not for the instances themselves, as in multi-instance learning. Past work on this problem has typically focused on learning classifiers to make predictions at the group level. In this paper we focus on the problem of learning classifiers to make predictions at the instance level. To achieve this we propose a new objective function that encourages smoothness of inferred instance-level labels based on instance-level similarity, while at the same time respecting group-level label constraints. We apply this approach to the problem of predicting labels for sentences given labels for reviews, using a convolutional neural network to infer sentence similarity. The approach is evaluated using three large review data sets from IMDB, Yelp, and Amazon, and we demonstrate the proposed approach is both accurate and scalable compared to various alternatives.
Cooperative load balancing for hierarchical SDN controllers

Software-defined networking (SDN) has been proposed as a new networking paradigm which separates the control and data forwarding planes. The controllers deployed as centralized network control entities are crucial for meeting the performance and efficiency requirements of these systems. The placement of these network entities, switch assignment and their load-aware operation are challenging research questions. Although various load-balancing schemes are proposed in the literature, this research topic is yet to be explored adequately. In this work, we discuss load-balancing issues in SDN and propose a load-balancing scheme, namely Cooperative Load Balancing Scheme For Hierarchical SDN Controllers (COLBAS), for hierarchical controller configurations. Moreover, we evaluate the performance of our scheme and investigate important performance factors.
Believing Is Doing: Emotion Regulation Beliefs Are Associated With Emotion Regulation Behavioral Choices and Subjective Well-Being

Research in emotion regulation has begun to examine various predictors of emotion regulation choices, including individual differences and contextual variables. However, scant attention has been paid to the extent to which people’s beliefs about the specific consequences of emotion regulation strategies for the components of an emotional response and long-term well-being predict their behavioral regulatory choices and, in turn, their subjective well-being. Participants completed measures to assess their beliefs about the consequences of functional and dysfunctional strategies, behavioral choices of emotion regulation strategies in negative scenarios, and subjective well-being. The model that fit the data indicated partial mediation whereby beliefs were associated with approximately 9% of the variance in choices. Emotion regulation choices were related to subjective well-being, with an additional direct effect between beliefs and well-being. This suggests beliefs play a role in people’s regulatory choices. Future research should explore how beliefs interact with individual differences and contextual variables to better understand why people regulate their emotions in different ways and, ultimately, to help individuals make healthy emotion regulation choices.
Gene Expression Signature and the Prediction of Ulcerative Colitis–Associated Colorectal Cancer by DNA Microarray

Purpose: Ulcerative colitis (UC) is associated with a high risk of colorectal cancer. To identify genes that could predict the development of cancer in UC, we conducted a DNA microarray analysis using nonneoplastic rectal mucosa of UC patients. Experimental Design: Gene expression in nonneoplastic mucosa of 53 UC patients were examined. Gene expression profiles were examined using human Genome U133 Plus 2.0 gene chip array (Affymetrix). Among 53 UC patients, 10 had UC-associated cancer (UC-Ca group) whereas 43 did not (UC-NonCa group). Results: By comparing gene expression profiles of nonneoplastic rectal mucosae between the UC-Ca and UC-NonCa groups, we could identify 40 genes that were differentially expressed between two groups. The list of discriminating genes included low-density lipoprotein receptor–related protein (LRP5 and LRP6). Previous studies suggested that LRP5 and LRP6 expression promotes cancer cell proliferation and tumorigenesis and are considered as candidate oncogenes. In the present study, both LRP5 and LRP6 showed significantly higher expression in the UC-Ca group, which suggests the importance of these genes in the development of UC-associated colorectal cancers. With the 40 selected discriminating genes, we did class prediction of the development of colorectal neoplasms in UC patients. Using the k-nearest neighbor method and the support vector machine, we could predict the development of UC-associated neoplasms with an accuracy of 86.8% and 98.1%, respectively. Conclusions: These findings have important implications for the early detection of malignant lesions in UC and may provide directions for future research into the molecular mechanisms of UC-associated cancer.
Fusion algebra of critical percolation

We present an explicit conjecture for the chiral fusion algebra of critical percolation considering Virasoro representations with no enlarged or extended symmetry algebra. The representations that we take to generate fusion are countably infinite in number. The ensuing fusion rules are quasi-rational in the sense that the fusion of a finite number of these representations decomposes into a finite direct sum of these representations. The fusion rules are commutative, associative and exhibit an structure. They involve representations which we call Kac representations of which some are reducible yet indecomposable representations of rank 1. In particular, the identity of the fusion algebra is a reducible yet indecomposable Kac representation of rank 1. We make detailed comparisons of our fusion rules with the recent results of Eberle–Flohr and Read–Saleur. Notably, in agreement with Eberle–Flohr, we find the appearance of indecomposable representations of rank 3. Our fusion rules are supported by extensive numerical studies of an integrable lattice model of critical percolation. Details of our lattice findings and numerical results will be presented elsewhere.
Evaluation of Adherence Should Become an Integral Part of Assessment of Patients With Apparently Treatment-Resistant Hypertension

Since the publication of the first Symplicity studies in 2009 to 2010, renal sympathetic denervation gained acceptance as a novel treatment of drug-resistant hypertension. The latter has been defined as a blood pressure (BP) >140/90 mm Hg, despite appropriate lifestyle measures plus a diuretic and 2 other antihypertensive drugs belonging to different classes at adequate doses.1 According to the US definition, patients with controlled BP on ≥4 antihypertensive drugs are also considered as resistant hypertensives.2 However, a substantial proportion of patients with apparently resistant hypertension are in fact poorly adherents to drug treatment. The highly variable BP response to renal denervation (RDN)3–5 prompted to a more rigorous evaluation of eligible patients, with the goal to exclude false resistant hypertension, because of poor adherence to drug treatment.6–8 In particular, several publications documented a high proportion of low drug adherence in patients with apparently resistant hypertension (23%–66%), using witnessed drug intake9 or plasma/urine drug determinations10–18 (Figure 1). Figure 1. Proportion of poor or nonadherence according to drug monitoring in different cohorts of patients with apparently resistant hypertension. Black indicates total nonadherence, whereas gray indicates partial adherence. Partial adherence was defined as the presence of at least one undetectable drug10–12,14,16–18 or as the presence of fewer medications than prescribed.13,15 Furthermore, RDN studies shed the light on the dynamic character of drug adherence. Inclusion in RDN trials may influence drug adherence in various, unpredictable directions.6 In some patients, close follow-up and massive attention devoted to them may lead to improved adherence to lifestyle measures and drug treatment, particularly in the RDN arm (Hawthorne effect). Other patients may stop their medications after RDN according to their perception that the intervention cured their …
Microindentation for in vivo measurement of bone tissue material properties in atypical femoral fracture patients and controls

Atypical femoral fractures (AFF) associated with long‐term bisphosphonates (LTB) are a growing concern. Their etiology is unknown, but bone material properties might be deteriorated. In an AFF series, we analyzed the bone material properties by microindentation. Four groups of patients were included: 6 AFF, 38 typical osteoporotic fractures, 6 LTB, and 20 controls without fracture. Neither typical osteoporotic fractures nor controls have received any antiosteoporotic medication. A general laboratory workup, bone densitometry by dual‐energy X‐ray absorptiometry (DXA), and microindentation testing at the tibia were done in all patients. Total indentation distance (Total ID), indentation distance increase (IDI), and creep indentation distance (Creep ID) were measured (microns). Age‐adjusted analysis of covariance (ANCOVA) was used for comparisons. Controls were significantly younger than fracture groups. Bisphosphonate exposure was on average 5.5 years (range 5 to 12 years) for the AFF and 5.4 years (range 5 to 8 years) for the LTB groups. Total ID (microns) showed better material properties (lower Total ID) for controls 36 (± 6; mean ± SD) than for AFF 46 (± 4) and for typical femoral fractures 47 (± 13), respectively. Patients on LTB showed values between controls and fractures, 38 (± 4), although not significantly different from any of the other three groups. IDI values showed a similar pattern 13 (± 2), 16 (± 6), 19 (± 3), and 18 (± 5). After adjusting by age, significant differences were seen between controls and typical (p < 0.001) and atypical fractures (p = 0.03) for Total ID and for IDI (p < 0.001 and p < 0.05, respectively). There were no differences in Creep ID between groups. Our data suggest that patients with AFF have a deep deterioration in bone material properties at a tissue level similar to that for the osteoporotic fracture group. The LTB group shows levels that are in between controls and both type of fractures, although not statistically different. These results suggest that bisphosphonate therapy probably does not put the majority of patients at risk for AFF. © 2013 American Society for Bone and Mineral Research
On the conducting and non-conducting electrical trees in XLPE cable insulation specimens

The conducting and non-conducting properties of electrical trees in cross-linked polyethylene (XLPE) cable insulation are studied by means of partial discharge (PD) measurement, optical microscope, confocal Raman microprobe spectroscopy and scanning electron microscopy (SEM). Specimens equipped with an embedded electrode system and constituted of a needle separated by approximately 2 mm from the counter electrode were utilized. Various types of electrical trees were produced at a range of voltage levels from 9 to 15 kV. It was found that the electrical trees grown at low voltage levels exhibited very different electrical properties from those grown at higher voltage levels. Branch-pine trees were formed at the low voltage conditions, displaying buildup of conducting main channels composed of disordered graphitic carbon deposited on the tree sidewalls. The average domain of the graphitic residues was estimated at the range of 8-8.4 nm in size, which resulted in a sufficient channel conductivity to suppress the PD activity within the main tree channels and caused growth of the pine structure. The branch trees, grown at higher voltage levels, showed typical characteristics of non-conducting trees, in which continuous discharges eroded the tree sidewalls and the observed intensity of fluorescence decreased evidently with the distance from the needle electrode to the tree tip. The bush trees at high voltage levels also showed the non-conducting characteristics. However, some carbonized residues were formed locally in them near the needle electrode, which can be connected to the long and intensive discharge activity during the tree growth.
Expanded Mental Health Benefits and Outpatient Depression Treatment Intensity

Background:The justification for higher cost-sharing for behavioral health treatment is its greater price sensitivity relative to general healthcare treatment. Despite this, recent policy efforts have focused on improving access to behavioral health treatment. Objectives:We measured the effects on outpatient treatment of depression of a change in mental health benefits for employees of a large U.S.-based corporation. Research Design:The benefit change involved 3 major elements: reduced copayments for mental health treatment, the implementation of a selective contracting network, and an effort to destigmatize mental illness. Claims data and a difference-in-differences methodology were used to examine how the benefit change affected outpatient treatment of depression. Subjects:Subjects consisted of 214,517 employee-years of data for individuals who were continuously enrolled for at least 1 full year at the intervention company and 96,365 employee-years in the control group. Measures:We measured initiation into treatment of depression and the number of outpatient therapy visits. Results:The benefit change was associated with a 26% increase in the probability of initiating depression treatment. Conditional on initiating treatment, patients in the intervention company received 1.2 additional (P < 0.001) outpatient mental health treatment visits relative to the control group. Conclusions:Our results suggest that the overall effect of the company's benefit change was to significantly increase the number of outpatient visits per episode of treatment conditional on treatment initiation.
Cognitive and Motivational Consequences of Tutoring and Discovery Learning

Abstract : A central controversy in the design of instruction concerns the amount of freedom or guidance that should be provided to students. We examined the cognitive and motivational consequences of guidance and freedom in a learning environment used by students learning introductory programming. Students worked with one of three interactive learning environments that varied in the amount of freedom to explore or guidance provided. We argue that discovery learning creates more opportunities for students to assess how well they can overcome obstacles, and their resulting attitudes toward their past and future success in the domain relies heavily on this type of attribution. The positive or negative nature of that attribution will depend on their relative success in achieving their goals.