Miracle-dz/UniFAR-FTUs huggingface dataset:
A Phase II Study of SGN-30 in Cutaneous Anaplastic Large Cell Lymphoma and Related Lymphoproliferative Disorders

Purpose: An open-label, multicenter, phase II study was conducted to define the safety and antitumor activity of the monoclonal antibody SGN-30 in patients with CD30+ primary cutaneous anaplastic large cell lymphoma (pc-ALCL), lymphomatoid papulosis (LyP), or transformed mycosis fungoides (T-MF). Experimental Design: In the initial course (six doses), patients received i.v. SGN-30 every 3 weeks; eligible patients could receive two additional courses. The initial dose level of 4 mg/kg was increased to 12 mg/kg by protocol amendment. Results: The overall objective response rate [complete response (CR) + partial response (PR)] was 70% (16 of 23 patients): 10 patients achieved a CR and another 6 patients achieved a PR. Overall, clinical benefit of SGN-30, as assessed by achieving a response to therapy or stable disease (CR + PR + stable disease), was shown by 87% of patients during the study, including all patients with pc-ALCL or LyP and two thirds of patients with T-MF or with multiple clinical diagnoses. Nine of the 10 patients who achieved a CR and 5 of the 6 patients who achieved a PR were in remission at their follow-up evaluation (median duration, 84 days). Fifteen of 23 patients (65%) experienced at least one adverse event during the study, most of which were mild or moderate. Conclusions: SGN-30 was clinically active in 16 of 23 patients with heavily pretreated pc-ALCL, LyP, and T-MF and was well tolerated in this study. (Clin Cancer Res 2009;15(19):6217–24)
Coordination of Word Parts is Interpreted at Surface Level

1. Coordination of Parts of Words In this paper I argue that coordination of parts of words, as in (1) below, has to be interpreted at the level of the visible string; as a consequence, the semantics must assign separate meanings to the word parts ortho, perio, and dontists (an orthodontist is a specialist in straightening teeth; a periodontist specializes in gum disease). (1) ortho and periodontists The evidence comes from the interpretation of plural morphology. Specifically, the NP ortho and periodontists is not synonymous with orthodontists and periodontists. Suppose that Bill is an orthodontist and Martha is a periodontist; then sentence (2) below has a reading on which it is true, whereas sentence (3) does not have a true reading. (2) Bill and Martha are ortho and periodontists. (3) #Bill and Martha are orthodontists and periodontists. The relevant structure for the interpretation of ortho and periodontists must therefore be different from that of orthodontists and periodontists. Notice that the contrast between (2) and (3) is similar to the contrast between (4) and (5) below: only the former receives a coherent reading. (4) Konishki and Takanohana are heavy and light sumo wrestlers. (5) #Konishki and Takanohana are heavy sumo wrestlers and light sumo wrestlers. * Earlier versions of this paper were presented at TLS-2001 at the University of Texas and to the Rutgers semantics group; I thank the audiences for their comments and insights. I owe particular thanks to Rajesh The responsibility for the views expressed in this paper, as well as any resulting inadequacies, is of course my own.
BLAST training : Estimating Channel Characteristics for High-Capacity Space-Time Wireless

BLAST (Bell Labs Layered Space-Time) is a multiple-antenna communication scheme whose outage capacity in a Rayleigh at fading environment grows linearly with the minimum of the number of transmit and receive antennas, with no increase in bandwidth or transmitted power. Based on its knowledge of the matrix of propagation coeecients, the receiver performs two critical operations: nulling and cancellation, that in eeect create independent virtual subchannels. Assume that the receiver estimates the propagation matrix from a known set of transmitted training signals, and then uses the estimate as though it were correct for nulling and cancellation. How much training is needed for satisfactory operation? The optimal training signals are orthogonal with respect to time among the transmit antennas, and each transmit antenna is fed equal energy. Errors in estimating the propagation matrix manifest themselves as crosstalk among the virtual subchannels. If its magnitude is too large, the crosstalk constitutes an outage event that is independent of the primary outage event (e.g., that the value of the propagation matrix cannot support the transmission rate). We show that the training interval required to control the probability of the estimation-error induced outage is approximately proportional to the number of transmit antennas, and is independent of the number of receive antennas. Contrary to what is implied by their names, the operations of nulling and cancellation are, in fact, robust with respect to estimation errors. Our results have an interesting implication for BLAST, either in a mobile environment , or for TDMA, where both training and data transmission have to occur within a xed interval: if one wishes to maximize the overall transmission rate, then the number of transmit antennas should be chosen such that half of the interval is used for training, and half of the interval for data transmission.
Dose-dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor-1

The prevalence of obesity, an established risk and progression factor for breast and many other cancer types, remains very high in the United States and throughout the world. Calorie restriction (CR), a reduced‐calorie dietary regimen typically involving a 20–40% reduction in calorie consumption, prevents or reverses obesity, and inhibits mammary and other types of cancer in multiple tumor model systems. Unfortunately, the mechanisms underlying the tumor inhibitory effects of CR are poorly understood, and a better understanding of these mechanisms may lead to new intervention targets and strategies for preventing or controlling cancer. We have previously shown that the anticancer effects of CR are associated with decreased systemic levels of insulin‐like growth factor‐1 (IGF‐1), the primary source of which is liver. We have also reported that CR strongly suppresses tumor development and growth in multiple mammary cancer models. To identify CR‐responsive genes and pathways, and to further characterize the role of IGF‐1 as a mediator of the anticancer effects of CR, we assessed hepatic and mammary gland gene expression, hormone levels and growth of orthotopically transplanted mammary tumors in control and CR mice with and without exogenous IGF‐1. C57BL/6 mice were fed either control AIN‐76A diet ad libitum (AL), subjected to 20%, 30%, or 40% CR plus placebo timed‐release pellets, or subjected to 30% or 40% CR plus timed‐release pellets delivering murine IGF‐1 (mIGF‐1, 20 μg/day). Compared with AL‐fed controls, body weights were decreased 14.3% in the 20% CR group, 18.5% in the 30% CR group, and 38% in the 40% CR group; IGF‐1 infusion had no effect on body weight. Hepatic transcriptome analyses indicated that compared with 20% CR, 30% CR significantly modulated more than twice the number of genes and 40% CR more than seven times the number of genes. Many of the genes specific to the 40% CR regimen were hepatic stress‐related and/or DNA damage‐related genes. Exogenous IGF‐1 rescued the hepatic expression of several metabolic genes and pathways affected by CR. Exogenous IGF‐1 also rescued the expression of several metabolism‐ and cancer‐related genes affected by CR in the mammary gland. Furthermore, exogenous IGF‐1 partially reversed the mammary tumor inhibitory effects of 30% CR. We conclude that several genes and pathways, particularly those associated with macronutrient and steroid hormone metabolism, are associated with the anticancer effects of CR, and that reduced IGF‐1 levels can account, at least in part, for many of the effects of CR on gene expression and mammary tumor burden.
VMVM: unit test virtualization for Java

As software evolves and grows, its regression test suites tend to grow as well. When these test suites become too large, they can eventually reach a point where they become too length to regularly execute. Previous work in Test Suite Minimization has reduced the number of tests in such suites by attempting to identify those that are redundant (e.g. by a coverage metric). Our approach to ameliorating the runtime of these large test suites is complementary, instead focusing on reducing the overhead of running each test, an approach that we call Unit Test Virtualization. This Tool Demonstration presents our implementation of Unit Test Virtualization, VMVM (pronounced "vroom-vroom") and summarizes an evaluation of our implementation on 20 real-world Java applications, showing that it reduces test suite execution time by up to 97% (on average, 62%). A companion video to this demonstration is available online, at https://www.youtube. com/watch? v=sRpqF3rJERI.
Multi-core for mobile phones

High-end mobile phones support multiple radio standards and a rich suite of applications, which involves advanced radio, audio, video, and graphics processing. The overall digital workload amounts to nearly 100GOPS, from 4b integer to 24b floating-point operations. With a power budget of only 1W this inevitably leads to heterogeneous multi-core architectures with aggressive power management. We review the state-of-theart as well as trends.
Evidence for a Life-Span Theory of Socioemotional Selectivity

3. R. Fendrich, CM. Wessinger, and M.S. GazI zaniga, Residual vision in a scotoma: Implications for blindsight, Science, 258, 1489-1491 (1992). 4. J.L. Barbur, J.D. G. Watson, R.S. j. Frackow iak, and S. Zeki, Conscious visual perception with out V1, Brain, 116, 1293 (1993). 5. A. Cowey and P. Stoerig, The neurobiology of blindsight, Trends in Neurosciences, 14, 140 (1991). 6. H.T. Rodman, CG. Gross, and T.D. Al bright, Afferent basis of visual response properties in area MT of the macaque: I. Effects of striate cortex removal, Journal of Neuroscience, 9, 2033 (1989). 7. A. Cowey, P. Stoerig, and V.H. Perry, Trans neuronal retrograde degeneration of retinal ganglion cells after damage to striate cortex in macaque mon keys: Selective loss of P-beta cells, Neuroscience, 29,65 (1989). 8. D.C Dennett, Consciousness Explained (Pen guin Press, London, 1991). 9. L. Weiskrantz, j.L. Barbur, and A. Sahraie, Parameters affecting conscious versus unconscious visual discrimination with damage to the visual corI tex (V1), Proceedings of the National Academy of Science, U.S.A. , 92, 6122-6126 (1995).
Assessing ecological correlates of marine bird declines to inform marine conservation

Identifying drivers of ecosystem change in large marine ecosystems is central for their effective management and conservation. This is a sizable challenge, particularly in ecosystems transcending international borders, where monitoring and conservation of long‐range migratory species and their habitats are logistically and financially problematic. Here, using tools borrowed from epidemiology, we elucidated common drivers underlying species declines within a marine ecosystem, much in the way epidemiological analyses evaluate risk factors for negative health outcomes to better inform decisions. Thus, we identified ecological traits and dietary specializations associated with species declines in a community of marine predators that could be reflective of ecosystem change. To do so, we integrated count data from winter surveys collected in long‐term marine bird monitoring programs conducted throughout the Salish Sea—a transboundary large marine ecosystem in North America's Pacific Northwest. We found that decadal declines in winter counts were most prevalent among pursuit divers such as alcids (Alcidae) and grebes (Podicipedidae) that have specialized diets based on forage fish, and that wide‐ranging species without local breeding colonies were more prone to these declines. Although a combination of factors is most likely driving declines of diving forage fish specialists, we propose that changes in the availability of low‐trophic prey may be forcing wintering range shifts of diving birds in the Salish Sea. Such a synthesis of long‐term trends in a marine predator community not only provides unique insights into the types of species that are at risk of extirpation and why, but may also inform proactive conservation measures to counteract threats—information that is paramount for species‐specific and ecosystem‐wide conservation.
Narrative Selves, Relations of Trust, and Bipolar Disorder

Abstract: For some people with bipolar disorder, excessive self-trust in the manic phase conflicts with trusting themselves over time, and radical shifts in mood and activity can undermine their trustworthiness. Difficulties in trust interface with the ability to construct a narrative. Although the narrative self may be (for anyone) fragmented and disjointed, it can nevertheless provide an unfolding rationale for the shape that one’s life has taken and will take. Many people with bipolar disorder experience themselves as fragmented where neither self-trust nor narrative can appropriately develop. Clinicians play a crucial role in extricating patients from this struggle for meaning in their lives. One aim of therapy may be to develop appropriate self-trust and to enhance patient trustworthiness through construction of a narrative where the patient is able to make sense of her changes to herself and others. Part of this joint task involves helping the patient to construct a narrative that accounts for effects of bipolar illness but is not driven by it. Because explanations of change from one mood or set of desires to another need to be deep enough to facilitate trust relations, the criteria for a narrative self must not be overly demanding of unity and similarity. This aim requires that the clinician be trustworthy with regard to the specific vulnerabilities of patients with bipolar disorder. This paper offers an outline of an approach psychotherapists should take to provide a kind of self-narrative–oriented therapy to help patients with bipolar disorder develop a sense of self that will help them to account for their illness while allowing patients see themselves as something more than just their illness.
Large-Scale Collective Entity Matching

There have been several recent advancements in Machine Learning community on the Entity Matching (EM) problem. However, their lack of scalability has prevented them from being applied in practical settings on large real-life datasets. Towards this end, we propose a principled framework to scale any generic EM algorithm. Our technique consists of running multiple instances of the EM algorithm on small neighborhoods of the data and passing messages across neighborhoods to construct a global solution. We prove formal properties of our framework and experimentally demonstrate the effectiveness of our approach in scaling EM algorithms.
Rozvoj prosociálního chování u žáků II. stupně základní školy v kontextu Etické výchovy

Eticka výchova je projekt vychazejici ze spanělskeho programu Rozvoj prosocialnosti, jehož autorem je Roche. Cilem Eticke výchovy je rozvoj prosocialniho chovani žaků a studentů. Disertacni prace se sklada ze dvou empirických studii. Cilem prvni empiricke studie je zjistit, jaký efekt ma realizace Eticke výchovy po dobu jednoho skolniho roku na žaky sestých a sedmých třid zakladni skoly (n = 115). Zvolili jsme design kvazi-experimentu s kontrolni a výzkumnou skupinou. Efekt Eticke výchovy sledujeme v těchto proměnných: klima a vztahy ve třidě, sebehodnoceni žaků a mira výskytu prosocialniho chovani u žaků. Cilem druhe empiricke studie je ziskat a zprostředkovat nazory samotných žaků na efektivitu předmětu Eticka výchova i na osobu ucitelky, ktera tento předmět vyucuje. Respondenti (n = 115) odpovidali na otevřene otazky. Tyto odpovědi jsme kategorizovali a kvantifikovali.
Necessity or Eccentricity—Teaching Writing in a New Media Ecology

ABSTRACT This article concerns how teachers of Mother-Tongue Education (MTE) and pupils in Swedish secondary schools look upon and relate to the keyboard and screen and pen and paper, respectively, for writing in the context of MTE. The results showed that both teachers and pupils found that the computer on one side and the pen and paper on the other circumscribed different writing processes. Paper and pen offered greater resistance when writing than a computer. It was concluded that writing on a computer had been culturally appropriated in the MTE and represented the frame for both teachers and students from which they assessed the advantages and disadvantages of each technology, but also that paper and pen added a value of necessity rather than eccentricity for the pupils, in contrast to the teachers, in order to meet the requirements concerning grammar, longhand, and orthography.
Neuroscience and Biobehavioral Reviews

Experimental evidence indicates that saccadic metrics vary with task difﬁculty and time-on-task in nat- uralistic scenarios. We explore historical and recent ﬁndings on the correlation of saccadic velocity with task parameters in clinical, military, and everyday situations, and its potential role in ergonomics. We moreover discuss the hypothesis that changes in saccadic velocity indicate variations in sympathetic nervous system activation; that is, variations in arousal
Interpreting the Significance of the Lagged Interest Rate in Estimated Monetary Policy Rules

Many researchers have found that the lagged interest rate enters estimated monetary policy rules with overwhelming significance, suggesting that policy adjusts gradually to changes in economic conditions. However, Rudebusch (2002) argues that the lagged interest rate is not a fundamental component of the U.S. policy rule, and that its significance arises from the omission of serially correlated variables from the policy rule. This paper considers the possibility that policy rules may be characterized by both partial adjustment and serially correlated omitted variables. Our findings indicate that even if one allows for serially correlated errors, partial adjustment plays an important role in describing the behavior of the federal funds rate.
Response maxima in modulated turbulence.

Isotropic and homogeneous turbulence driven by an energy input modulated in time is studied within a variable range mean-field theory. The response of the system, observed in the second-order moment of the large-scale velocity difference D(L,t)=<<(u(x+L)-u(x))(2)>> proportional, variant Re(2)(t), is calculated for varying modulation frequencies omega and weak modulation amplitudes. For low frequencies the system follows the modulation of the driving with almost constant amplitude, whereas for higher driving frequencies the amplitude of the response decreases on average proportional, variant 1/omega. In addition, at certain frequencies the amplitude of the response either almost vanishes or is strongly enhanced. These frequencies are connected with the frequency scale of the energy cascade and multiples thereof.
Gastrodia Elata Bl Attenuates Cocaine-Induced Conditioned Place Preference and Convulsion, but not Behavioral Sensitization in Mice: Importance of GABAA Receptors

It has been suggested that GABAergic neurotransmission can modulate cocaine dependence and seizure activity. Since Gastrodia elata Bl (GE), an oriental herb agent, has been shown to enhance GABAergic transmission, we examined whether GE affects cocaine-induced seizures, conditioned place preference (CPP), and behavioral sensitization in mice. Treatment with GE (500 or 1000 mg/kg, p.o.) significantly delayed seizure onset time and significantly shortened seizure duration induced by cocaine (90 mg/kg, i.p.). In addition, cocaine (15 mg/kg, i.p.)-induced CPP was significantly attenuated by GE in a dose-dependent manner. However, GE did not significantly alter behavioral sensitization induced by cocaine (15 mg/kg, i.p.). In order to understand whether GABAergic receptors are implicated in GE-mediated pharmacological action in response to cocaine, GABAA receptor antagonist bicuculline and GABAB receptor antagonist SCH 50911 were employed in the present study. GE-mediated attenuations on the cocaine-induced seizures and CPP were significantly reversed by bicuculline (0.25 or 0.5 mg/kg, i.p.), but not by SCH 50911 (1.5 or 3.0 mg/kg, i.p.). Therefore, our results suggest that GE attenuates cocaine-induced seizures and CPP via, at least in part, GABAA receptor activation.
Cloud Types: Robust Abstractions for Replicated Shared State

In the age of cloud-connected mobile devices, users want responsive apps that read and write shared data everywhere, at all times, even if network connections are slow or unavailable. Cloud types [6] have been proposed as a solution that lets programmers declare, read, and update shared structured data while hiding tricky consistency issues related to update propagation and conflict resolution. However, previous work on cloud types does not satisfactorily address (1) how to best understand the weak consistency model, (2) where consistency pitfalls continue to lurk, and (3) how to implement the system efficiently and reliably. We address these questions by (1) introducing the GLUT model (global log of update transactions), suitable as a mental reference model that helps programmers to visualize executions and reason about correctness, (2) describing typical consistency pitfalls (anti-patterns) and how to avoid them using cloud types, and (3) an efficient client-server implementation of GLUT that uses robust streaming and optimal delta reduction.
Chronic hepatitis virus infections in patients on renal replacement therapy.

between the sympathetic nervous system and sodium potassium adenosine triphosphatase inhibitor in salt-sensitive patients with essential hypertension. salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease. Blood Purif 2002; 20: 466–468 10. Aviv A. Salt consumption, reactive oxygen species and cardiovas-cular ageing: a hypothetical link.gen peroxide production in hypertensives and normotensive subjects at genetic risk of hypertension. Salt sensitivity of blood pressure in chronic renal failure. Evidence for renal control of body fluid distribution in man. AP. Effects of hemodialysis and saline loading on body fluid compartments, plasma renin activity, and blood pressure in patients on chronic hemodialysis. Blankestijn PJ. Sympathetic nerve activity is inappropriately increased in chronic renal disease. Regression of left ventricular hypertrophy in haemodialysis patients by ultrafiltration and reduced salt intake without antihypertensive drugs. Kooman JP et al. Ionic mass balance and blood volume preservation during a high, standard, and individualized dialysate sodium concentration. Dietary salt restriction and reduction of dialysate sodium to control hypertension in maintenance haemodialysis patients.independent contribution of sodium to large artery structure and function in hypertension. van Bortel LM et al. Vascular compliance in sodium-sensitive and sodium-resistant borderline hypertensive patients. II activates nuclear transcription factor kB through AT 1 and AT 2 in vascular smooth muscle cells: molecular mechanisms. The magnitude of the problem Hepatitis B (HBV) and C (HCV) virus infections represent a major problem in dialysis patients and renal allograft recipients.