Miracle-dz/UniFAR-FTUs huggingface dataset:
Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis

The interactions of tumor cells with platelets contribute to the progression of tumor malignancy, and the expression levels of platelet aggregation‐inducing factors positively correlate with the metastatic potential of osteosarcoma cells. However, it is unclear how tumor‐platelet interaction contributes to the proliferation of osteosarcomas. We report here that osteosarcoma‐platelet interactions induce the release of platelet‐derived growth factor (PDGF) from platelets, which promotes the proliferation of osteosarcomas. Co‐culture of platelets with MG63 or HOS osteosarcoma cells, which could induce platelet aggregation, enhanced the proliferation of each cell line in vitro. Analysis of phospho‐antibody arrays revealed that co‐culture of MG63 cells with platelets induced the phosphorylation of platelet derived growth factor receptor (PDGFR) and Akt. The addition of supernatants of osteosarcoma‐platelet reactants also increased the growth of MG63 and HOS cells as well as the level of phosphorylated‐PDGFR and ‐Akt. Sunitinib or LY294002, but not erlotinib, significantly inhibited the platelet‐induced proliferation of osteosarcoma cells, indicating that PDGF released from platelets plays an important role in the proliferation of osteosarcomas by activating the PDGFR and then Akt. Our results suggest that inhibitors that specifically target osteosarcoma‐platelet interactions may eradicate osteosarcomas.
The Complex Relationship between Forecast Skill and Forecast Value: A Real-World Analysis

Abstract For routine forecasts of temperature and precipitation, the relative skill advantage of human forecasters with respect to the numerical–statistical guidance is small (and diminishing). Since the relationship between forecast skill and the value of those forecasts is complex, the authors have examined their value across a range of real-world user contexts. It is found that although in most cases the meteorological information possessed considerable value to the users, human intervention in making those forecasts (as measured by National Weather Service forecasts) has generally led to minimal gains in value beyond that which is obtainable through direct use of numerical–statistical guidance. An important exception is the use of meteorological information by gas utilities during peak wintertime periods; in those circumstances, the value of human intervention was considerable. The presence of information in the National Weather Service forecasts independent of that contained in the numerical–statisti.
Chorioretinal Coloboma Complications: Retinal Detachment and Choroidal Neovascular Membrane

Purpose: To report the chorioretinal coloboma, and its association with increased risk of retinal detachment (RD) and choroidal neovascularization (CNV). Methods: This retrospective case series included eyes with chorioretinal coloboma diagnosed between 1995 and 2014 with a focus on RD and CNV as related complications. Cases of CNV were managed with laser photocoagulation or intravitreal injection of bevacizumab. For eyes with CNV, therapeutic success was defined as resolution of the subretinal hemorrhage on fundus examination and resolution of the subretinal and intraretinal fluid on optical coherence tomography (OCT). For eyes with RD, anatomic success following surgical intervention was defined as attachment of the retina at the last follow-up visit. Results: Fifty-one eyes of 31 patients with chorioretinal coloboma were identified for review. Bilateral chorioretinal coloboma was present in 64.5% of subjects. RD developed in 15 eyes (29.4%). Among 15 eyes with RD, 4 eyes (27%) had retinal breaks identified within the coloboma, 5 eyes (33%) had retinal breaks outside the coloboma, 2 eyes (13%) showed retinal breaks both inside and outside the coloboma, and in 4 eyes (27%) the causative retinal break was not localized. The overall rate of anatomic success after RD repair was 85.7%. CNV developed in 7 eyes (13.7%) and was located along the margin of the coloboma in all cases. CNV was bilateral in 2 of the 5 affected individuals (40%). Conclusion: RD and CNV were present in a high percentage of eyes with chorioretinal coloboma in these series. The frequent finding of retinal breaks outside the coloboma bed suggests that vitreoretinal interface abnormalities may play a role in development of RD in these eyes.
Investigating event-related potentials in spider phobia

8 Acknowledgment . 9 Introduction . 10 Selective attention . 11 The concept of attention . 11 Attention as structure or capacity . 11 A possible integration: Load theory . 12 Visual attention . 14 Emotion . 16 Types or dimensions of emotionality . 16 Emotion elicitation . 16 Phobia . 17 Emotion and attention . 19 Attentional bias to emotion . 19 Emotion without top-down attention . 20 Event-related potentials . 22 P1 . 22 EPN . 23 LPP . 23 Summary of studies . 26 Study I . 26 Study II . 28 Study III . 30 General discussion . 33 References . 37
PENGARUH GAYA HIDUP HEDONIS, KETERLIBATAN FASHION DAN VISUAL MERCHANDISING TERHADAP PEMBELIAN IMPULSIF

ABSTRACT This research is meant to examine the influence of hedonic lifestyle, fashion involvement and visual merchandising to the impulsive buying through positive emotion. The population is all customers at Matahari Department Store Plaza Surabaya which is located on Jl. Pemuda No. 31-37, Surabaya. The sample collection technique has been conducted by using purposive sampling with the numbers of samples are 100 respondents. The data analysis technique has been carried out by using validity test and reliability test, classic assumption test and path analysis which has been conducted.The result of the test shows that hedonic lifestyle is proven to have positive and significant influence to the impulsive buying whereas fashion involvement is not proven to have significant influence to the impulsive buying,and visual merchandising is not proven to have positive influence to the impulsive buying, mean while the positive emotion does not have any significant influence to the impulsive buyers. The result of this research shows that the magnitudeof the indirect influence of hedonic lifestyle, fashion involvement, and visual merchandising to the impulsive buying through positive emotion which is larger than the direct influence of hedonic lifestyle, fashion involvement and visual merchandising to the impulsive buying. Keywords: hedonism lifestyle, fashion involve, visual merchandising, positive emotion, impulsive purchasing.
Physical Games as a Means of Developing Children’s Social Skills in Kindergarten

Abstract Introduction: The text presents the results of a study conducted in the years 2015 - 2016. The objective of the study was to examine a programme of physical activities aimed at developing children’s social skills. Methods: The research was conducted in a kindergarten. This was a deliberate choice on the basis of availability. The experimental group comprised of 24 children, the control group comprised of 11 children. A 12-lessons programme of physical activities was applied, with a frequency of 1 lesson per week. Entry and exit measurements were taken before the commencement of the programme and after its end, with the help of structured observation, CATO projective tests and interviews with teachers. The data were processed by means of a descriptive statistics level by comparing the average levels. The achieved changes in the level of social skills were subsequently displayed through percentage values. Results: The results indicate that physical activities have a positive effect on the development of children’s social skills. Although the changes are not significant, the experimental group recorded greater changes than the control group in all the evaluated areas; in terms of the overall results, it was actually more than twofold. Discussion: The results cannot be generalized. The results are only valid for our group of children. The reason is the insufficient size of the research sample. Limitations: A significantly limiting factor showed to be the low number of children in the control group. This caused a lack of balance between the two groups in terms of the number of children and their entry level. The length of the intervention program was another limit. Conclusions: Despite the limits of the study, the authors view the results as positive. The reason is the improvement in all the children’s social skills in all the monitored areas, and the more than twofold improvement by the experimental groups compared to the control group.
Efficient Semi-Supervised Feature Selection: Constraint, Relevance, and Redundancy

This paper describes a three-level framework for semi-supervised feature selection. Most feature selection methods mainly focus on finding relevant features for optimizing high-dimensional data. In this paper, we show that the relevance requires two important procedures to provide an efficient feature selection in the semi-supervised context. The first one concerns the selection of pairwise constraints that can be extracted from the labeled part of data. The second procedure aims to reduce the redundancy that could be detected in the selected relevant features. For the relevance, we develop a filter approach based on a constrained Laplacian score. Finally, experimental results are provided to show the efficiency of our proposal in comparison with several representative methods.
Beginning spelling and literacy approaches: A comparative study between French and Québécois first-grade classes

Many studies note the difficulties experienced by young children in learning deep writing sys- tems (such as English and French) compared to those for which the link between the spoken and the written is shallower (e.g., Spanish and Italian). A large percentage of these studies are focused on English. As such, more research needs to be conducted with other first languages such as French. The present exploratory study seeks to understand the effects of these kinds of linguistic variable, along with the impact (which has received little attention) of instructional factors, on the competencies of first-grade, French-language writers. Two kinds of instructional context are examined (integrated approach vs code-oriented approach) in two countries (France and Quebec, Canada). The main findings for invented spelling situations within an integrated-approach framework reveal that French and Quebec pupils construct a more complete view of the writing system. This construction includes both units involving the transcription of phonemes by phonograms and units involving the treatment of inaudible, semiographic information by morphograms. mais completa do sistema de escrita. Esta visão inclui tanto as unidades implicadas na transcrição de fonemas por fonogramas como as unidades implicadas no tratamento de informação inaudível e semiográfica por morfogramas. Palavras-chave: língua francesa, 1º ano de escolaridade, ortografia inventada, abordagens instrucionais da literacia, desenvolvimento ortográfico.
Transcranial Near-Infrared Laser Transmission (NILT) Profiles (800 nm): Systematic Comparison in Four Common Research Species

Background and Purpose Transcranial near-infrared laser therapy (TLT) is a promising and novel method to promote neuroprotection and clinical improvement in both acute and chronic neurodegenerative diseases such as acute ischemic stroke (AIS), traumatic brain injury (TBI), and Alzheimer’s disease (AD) patients based upon efficacy in translational animal models. However, there is limited information in the peer-reviewed literature pertaining to transcranial near-infrared laser transmission (NILT) profiles in various species. Thus, in the present study we systematically evaluated NILT characteristics through the skull of 4 different species: mouse, rat, rabbit and human. Results Using dehydrated skulls from 3 animal species, using a wavelength of 800nm and a surface power density of 700 mW/cm2, NILT decreased from 40.10% (mouse) to 21.24% (rat) to 11.36% (rabbit) as skull thickness measured at bregma increased from 0.44 mm in mouse to 0.83 mm in rat and then 2.11 mm in rabbit. NILT also significantly increased (p<0.05) when animal skulls were hydrated (i.e. compared to dehydrated); but there was no measurable change in thickness due to hydration. In human calvaria, where mean thickness ranged from 7.19 mm at bregma to 5.91 mm in the parietal skull, only 4.18% and 4.24% of applied near-infrared light was transmitted through the skull. There was a slight (9.2-13.4%), but insignificant effect of hydration state on NILT transmission of human skulls, but there was a significant positive correlation between NILT and thickness at bregma and parietal skull, in both hydrated and dehydrated states. Conclusion This is the first systematic study to demonstrate differential NILT through the skulls of 4 different species; with an inverse relationship between NILT and skull thickness. With animal skulls, transmission profiles are dependent upon the hydration state of the skull, with significantly greater penetration through hydrated skulls compared to dehydrated skulls. Using human skulls, we demonstrate a significant correlation between thickness and penetration, but there was no correlation with skull density. The results suggest that TLT should be optimized in animals using novel approaches incorporating human skull characteristics, because of significant variance of NILT profiles directly related to skull thickness.
On the Efficient Implementation of Social Abstract Argumentation

In this paper we present a novel iterative algorithm -the Iterative Successive Substitution (ISS) - to efficiently approximate the models of debates structured according to Social Abstract Argumentation [10]. Classical iterative algorithms such as the Iterative Newton-Raphson (INR) and the Iterative Fixed-point (IFP) don't always converge and, when they do, usually take too long to be effective. We analytically prove convergence of ISS, and empirically show that, even when INR and IFP converge, ISS always outperforms them, often by several orders of magnitude. The ISS is able to approximate the models of complex debates with thousands of arguments in well under a second, often in under one tenth of a second, making it comfortably suitable for its purpose. Additionally, we present a small modification to ISS that, with a negligible overhead, takes advantage of the topological structure of certain debates to significantly increase convergence times.
Heterogeneous guilt sensitivities and incentive effects

Psychological games of guilt aversion assume that preferences depend on (beliefs about) beliefs and on the guilt sensitivity of the decision-maker. We present an experiment designed to measure guilt sensitivities at the individual level for various stake sizes. We use the data to estimate a structural choice model that allows for heterogeneity, and permits that guilt sensitivities depend on stake size. We find substantial heterogeneity of guilt sensitivities in our population, with 60% of decision makers displaying stake-dependent guilt sensitivity. For these decision makers, we find that average guilt sensitivities are significantly different from zero for all stakes considered, while significantly decreasing with the level of stakes.
Pollution events observed during CARIBIC flights in the upper troposphere between South China and the Philippines

Abstract. A strong pollution episode in the upper troposphere between South China and the Philippines was observed during CARIBIC flights in April 2007. Five pollution events were observed, where enhancements in aerosol and trace gas concentrations including CO, CO2, CH4, non-methane hydrocarbons (NMHCs) and halocarbons were observed along the flight tracks during four sequential flights. The importance of the contribution of biomass/biofuel burning was investigated using chemical tracers, emission factor analysis, back-trajectory analysis and satellite images. The Indochinese peninsula was identified as the probable source region of biomass/biofuel burning. However, enhancements in the urban/industrial tracer C2Cl4 during the events also indicate a substantial contribution from urban anthropogenic emissions. An estimation of the contribution of fossil fuel versus biomass/biofuel to the CO enhancement was made, indicating a biomass/biofuel burning contribution of ~54 to ~92% of the observed CO enhancements. Biomass/biofuel burning was found to be the most important source category during the sampling period.
Emotional extremes and attachment in conflictual romantic relationships.

EMOTIONAL EXTREMES AND ATTACHMENT IN CONFLICTUAL ROMANTIC RELATIONSHIPS SEPTEMBER 1993 HILLARY JEAN MORGAN, B.A., POMONA COLLEGE M.S., UNIVERSITY OF MASSACHUSETTS AMHERST Ph.D., UNIVERSITY OF MASSACHUSETTS AMHERST Directed by: Professor Paula Pietromonaco Three studies explored people's experience of intense emotion in conflictual and non-conf lictual romantic relationships. All studies showed that when subjects reported how they generally experienced emotion in their relationship, people in highly conflictual relationships reported equally intense positive emotion and more intense negative emotion than people in non-conf lictual relationships. Study 3 also showed that when subjects described their emotional reactions to specific happy times in their relationship, people in more conflictual relationships reported more love and marginally more idealization of their partners than people in less conflictual relationships. There is some evidence that women in high conflict relationships differ from women in low conflict relationships on certain personality variables. High Conflict women score higher than Low Conflict women on
Qana’ah pada Mahasiswa Ditinjau dari Kepuasan Hidup dan Stres

Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara kepuasan hidup dan stres terhadap qana’ah pada mahasiswa. Subjek dalam penelitian ini berjumlah 105 mahasiswa. Analisis data yang digunakan adalah regresi berganda dan uji beda. Qana’ah diukur menggunakan skala qana’ah dari Rusdi (2016) (Cronbach’s Alpha = 0,810), kepuasan hidup diukur menggunakan Satisfaction Life Scale (SWLS) yang telah diujicobakan oleh Krisnawati (2015) yang mengacu pada teori Diener, dkk (1985) (Cronbach’s Alpha 0,828), dan stres diukur menggunakan skala yang telah diujicobakan oleh Sari dan Uyun (2016) yang merujuk pada aspek-aspek stres dari Sarafino (2012) (Cronbach’s Alpha = 0,869). Hasil dari penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara kepuasan hidup dan stres terhadap qana’ah pada mahasiswa ( p = 0.002, F = 6.559 ). Selain itu, terdapat hubungan positif yang signifikan antara kepuasan hidup dan qana’ah pada mahasiswa ( p = 0.003, r = 0.267 ) dan terdapat hubungan negatif yang signifikan antara stres dan qana’ah pada mahasiswa ( p = 0.005, r = -0.249 ).
Orthogonal Nearest Neighbor Feature Space Embedding

In this paper, a novel manifold learning algorithm termed orthogonal nearest neighbor feature space embedding (ONNFSE) is proposed to eliminate three drawbacks of the nearest feature space embedding (NFSE) approach. The first one is an extrapolation error, a feature line passes through two far neighbor points is selected for scatter matrix calculating when the distance of a specified point to this line is small. The calculated scatter matrix could not efficiently preserve the local topological structure among samples. The incorrect selection will reduce the recognition rates. The interpolation error is similar the extrapolation one. To remedy these two problems, the nearest neighbor feature space is built in the proposed ONNFSE. The last problem should be solved is the non-orthogonal eigenvectors found by the NFSE algorithm. The modified ONNFSE algorithm generates orthogonal bases which possess the more discriminating power. Experimental results are conducted to demonstrate the effectiveness of our proposed algorithm.
Massive Vacua of N=1* Theory and S Duality from Matrix Models

In this note we show how Dijkgraaf and Vafa's hypothesis relating the exact superpotential of an = 1 theory to a matrix model can be used to describe all the massive vacua of the = 1*, or mass deformed = 4, theory including the Higgs vacuum. The matrix model computation of the superpotential for each massive vacuum independently yields a modular function of the associated effective coupling in that vacuum which agrees with previously derived results up to a vacuum-independent additive constant. The results in the different massive vacua can be related by the action of SL(2,) on the = 4 coupling, thus providing evidence for modular invariance of the underlying = 4 theory.
Distributed flocking control of mobile robots by bounded feedback

Flocking control of multiple agents with their point-mass models has been extensively studied. However, flocking control of mobile robots with full dynamic models is challenging research due to nonhonolomic nature. This paper presents a novel approach to distributed flocking control of nonholonomic mobile robots by bounded feedback. The flocking control objectives include velocity consensus, collision avoidance, and cohesion maintenance among mobile robots. A flocking protocol which is based on the neighborhood information of mobile robots is constructed by means of control design. A Lyapunov-like function and graph theory are employed for convergence analysis. Simulation results are presented to illustrate the effectiveness of the proposed distributed flocking control scheme.
Evaluation of The Erosive Potential of Soft Drinks

Objectives This in vitro study evaluated the capability of different soft drinks (Coca-Cola®-C, Coca-Cola Light®-CL, Guaraná®-G, Pepsi Twist®-P and Sprite Light®-SL) to erode dental enamel, relating the percentage of superficial microhardness change (%SMHC) to concentrations of fluoride and phosphate, buffering capacity and pH of these drinks. Methods The soft drinks were evaluated in respect to concentration of phosphate and fluoride spectrophotometrically using Fiske, Subarrow method and by specific electrode (Orion 9609), respectively. The pH and the buffering capacity were determined by glass electrode and by estimating of the volume of NaOH necessary to change the pH of the drink in one unit, respectively. One hundred specimens of bovine enamel were randomly assigned to 5 groups of 20 each. They were exposed to 4 cycles of demineralisation in the beverage and remineralisation in artificial saliva. The softening of enamel was evaluated by %SMHC. Results The mean %SMHC was: C=77.27%, CL= 72.45%, SL=78.43%, G=66.65% and P=67.95%. Comparing the %SMHC promoted by 5 soft drinks, SL = C > CL > P = G (P<.05). There was not significant correlation between %SMHC and the other variables tested for the five drinks (P>.05). Conclusions The five soft drinks caused surface softening of enamel (erosion). In respect to the chemical variables tested, despite not statistically significant, the pH seems to have more influence on the erosive potential of these drinks. (Eur J Dent 2007;1:10–13)