Miracle-dz/UniFAR-FTUs huggingface dataset:
Temporal biomass dynamics of an Arctic plankton bloom in response to increasing levels of atmospheric carbon dioxide

Ocean acidification and carbonation, driven by anthropogenic emissions of carbon dioxide (CO 2 ), have been shown to affect a variety of marine organisms and are likely to change ecosystem functioning. High latitudes, especially the Arctic, will be the first to encounter profound changes in carbonate chemistry speciation at a large scale, namely the under-saturation of surface waters with respect to aragonite, a calcium carbonate polymorph produced by several organisms in this region. During a CO 2 perturbation study in Kongsfjorden on the west coast of Spitsbergen (Norway), in the framework of the EU-funded project EPOCA, the temporal dynamics of a plankton bloom was followed in nine mesocosms, manipulated for CO 2 levels ranging initially from about 185 to 1420 μatm. Dissolved inorganic nutrients were added halfway through the experiment. Autotrophic biomass, as identified by chlorophyll a standing stocks (Chl a ), peaked three times in all mesocosms. However, while absolute Chl a concentrations were similar in all mesocosms during the first phase of the experiment, higher autotrophic biomass was measured as high in comparison to low CO 2 during the second phase, right after dissolved inorganic nutrient addition. This trend then reversed in the third phase. There were several statistically significant CO 2 effects on a variety of parameters measured in certain phases, such as nutrient utilization, standing stocks of particulate organic matter, and phytoplankton species composition. Interestingly, CO 2 effects developed slowly but steadily, becoming more and more statistically significant with time. The observed CO 2 -related shifts in nutrient flow into different phytoplankton groups (mainly dinoflagellates, prasinophytes and haptophytes) could have consequences for future organic matter flow to higher trophic levels and export production, with consequences for ecosystem productivity and atmospheric CO 2 .
A study on evaluation and characterization of extruded product by using various by-products

Broken rice flour was added in proportions (75%) to equal amount of dehydrated pineapple waste pulp powder and red gram powder (12.5%) were extruded in a twin-screw extruder. The formulation was extruded at different moisture content (17-21%), screw speed (260-340 rpm) and die temperature (120140°C). The lateral expansion, bulk density, water absorption index, water solubility index, hardness and sensory characteristics were measured as responses. In the experiments, increase in barrel temperature resulted in extrudate with higher expansion, higher hardness, lower bulk density, lower WSI and higher WAI. Increasing in screw speed resulted in higher expansion, lower bulk density, higher overall acceptability and lower hardness; whereas, increasing level of moisture resulted in lower hardness, lower expansion and minimum bulk density and higher overall acceptability. In the experiment, optimization studies resulted in 132.27°C of barrel temperature, 315 rpm of screw speed and 18.48% of feed moisture.
Locked nucleic acid-inhibitor of miR-205 decreases endometrial cancer cells proliferation in vitro and in vivo

Pathogenesis of endometrial cancer has been connected with alterations of microRNA expression and in particular miR-205 up–regulation was consistently reported in this carcinoma. Presented study aimed to investigate if inhibition of miR-205 expression using LNA-modified-nucleotide would attenuate endometrial cancer cells proliferation in vitro and in vivo. In the course of the study we found that the proliferation of endometrial cancer cells (HEC-1-B, RL-95, KLE, Ishikawa) transfected with LNA-miR-205-inhibitor and evaluated using real time cell monitoring as well as standard cell proliferation assay, was significantly decreased. Next, LNA-miR-205-inhibitor was used to assess the in vivo effects of miR-205 inhibition of endometrial cancer growth. Cby.Cg-Foxn1/cmdb mice bearing endometrial cancer xenografts were intraperitoneally injected with nine dosages of 25mg/kg of miR-205-LNA-inhibitor or scramble control or phosphatase buffered saline and were observed for 32 days. We found that systemic administration of miR-205-LNA-inhibitor was technically possible, and exerted inhibitory effect on endometrial cancer xenograft growth in vivo with only mild toxic effects in treated animals. In conclusion our results suggest that systemic delivery of miR-205-LNA-inhibitor is feasible, devoid of significant toxicity, and could be a promising treatment strategy for endometrial cancer. Therefore it warrants further studies in other animal models.
New insights into the atmospheric mercury cycling in central Antarctica andimplications on a continental scale

Abstract. Under the framework of the GMOS project (Global Mercury Observation System) atmospheric mercury monitoring has been implemented at Concordia Station on the high-altitude Antarctic plateau (75°06′ S, 123°20′ E, 3220 m above sea level). We report here the first year-round measurements of gaseous elemental mercury (Hg(0)) in the atmosphere and in snowpack interstitial air on the East Antarctic ice sheet. This unique data set shows evidence of an intense oxidation of atmospheric Hg(0) in summer (24-hour daylight) due to the high oxidative capacity of the Antarctic plateau atmosphere in this period of the year. Summertime Hg(0) concentrations exhibited a pronounced daily cycle in ambient air with maximal concentrations around midday. Photochemical reactions and chemical exchange at the air–snow interface were prominent, highlighting the role of the snowpack on the atmospheric mercury cycle. Our observations reveal a 20 to 30 % decrease of atmospheric Hg(0) concentrations from May to mid-August (winter, 24 h darkness). This phenomenon has not been reported elsewhere and possibly results from the dry deposition of Hg(0) onto the snowpack. We also reveal the occurrence of multi-day to weeklong atmospheric Hg(0) depletion events in summer, not associated with depletions of ozone, and likely due to a stagnation of air masses above the plateau triggering an accumulation of oxidants within the shallow boundary layer. Our observations suggest that the inland atmospheric reservoir is depleted in Hg(0) in summer. Due to katabatic winds flowing out from the Antarctic plateau down the steep vertical drops along the coast and according to observations at coastal Antarctic stations, the striking reactivity observed on the plateau most likely influences the cycle of atmospheric mercury on a continental scale.
Psychopharmacologic treatment and blood transfusion in fast‐track total hip and knee arthroplasty

Selective serotonin reuptake inhibitors (SSRIs) and other psychotropics are receiving increasing attention due to reports on inhibition of thrombocyte function and an increased bleeding risk in surgical settings. Studies in total hip and total knee arthroplasty (THA and TKA, respectively) have shown conflicting results, questioning whether the potential increased bleeding risk is of clinical importance.
Cold platelets for trauma‐associated bleeding: regulatory approval, accreditation approval, and practice implementation—just the “tip of the iceberg”

Laboratory and clinical evidence suggest that cold‐stored platelets (CS‐PLTs) might be preferable to room temperature platelets (RT‐PLTs) for active bleeding. Ease of prehospital use plus potential hemostatic superiority led our facility to pursue approval of CS‐PLTs for actively bleeding trauma patients.
Cadmium increases ferroportin-1 gene expression in J774 macrophage cells via the production of reactive oxygen species

Cadmium intoxication has been associated with the dysregulation of iron homeostasis. In the present study, we investigated the effect of cadmium on the expression of ferroportin 1 (FPN1), an important iron transporter protein that is involved in iron release from macrophages. When we incubated cadmium with J774 mouse macrophage cells, FPN1 mRNA levels were significantly increased in a dose- and time-dependent manner. Furthermore, the cadmium-induced FPN1 mRNA expression was associated with increased levels of FPN1 protein. On the other hand, cadmium-mediated FPN1 mRNA induction in J774 cells was completely blocked when cells were co-treated with a transcription inhibitor, acitomycin D. Also, cadmium directly stimulated the activity of the FPN1-promoter driven luciferase reporter, suggesting that the cadmium up-regulates FPN1 gene expression in a transcription-dependent manner. Finally, cadmium exposure to J774 macrophages increased intracellular reactive oxygen species (ROS) levels by ~ 2-fold, compared to untreated controls. When J774 cells were co-treated with antioxidant N-acetylcystein, the cadmium-induced FPN1 mRNA induction was significantly attenuated. In summary, the results of this study clearly demonstrated that cadmium increased FPN1 expression in macrophages through a mechanism that involves ROS production, and suggests another important interaction between iron and cadmium metabolism.
Hybrid precoding for multi-user mmWave systems based on MMSE criterion

Millimeter wave (mmWave) communication has been considered as a key technology for future 5G or beyond wireless communication systems due to its huge spectrum bandwidth and great potential when combined with the large scale antenna technology. Considering the new challenge of high hardware cost and huge power consumption with the increase of bandwidth and number of antennas, hybrid digital and analog signal processing has been receiving a lot of interest recently. This paper investigates the hybrid precoding for multi-user communication in a downlink mmWave system, aiming at minimizing the sum of the users' mean square errors (sum-MSE) with the constraints of maximum transmit power and constant modulus for the phase shifters in the radio frequency precoding block. A two-stage optimization scheme is proposed to obtain a near-optimal solution. Simulation results show that the proposed hybrid precoding scheme performs closely to the fully digital precoding scheme.
Standardized reporting of functioning information on ICF-based common metrics.

BACKGROUND In clinical practice and research a variety of clinical data collection tools are used to collect information on people's functioning for clinical practice and research and national health information systems. Reporting on ICF-based common metrics enables standardized documentation of functioning information in national health information systems. The objective of this methodological note on applying the ICF in rehabilitation is to demonstrate how to report functioning information collected with a data collection tool on ICF-based common metrics. We first specify the requirements for the standardized reporting of functioning information. Secondly, we introduce the methods needed for transforming functioning data to ICF-based common metrics. Finally, we provide an example. METHODS The requirements for standardized reporting are as follows: 1) having a common conceptual framework to enable content comparability between any health information; and 2) a measurement framework so that scores between two or more clinical data collection tools can be directly compared. The methods needed to achieve these requirements are the ICF Linking Rules and the Rasch measurement model. Using data collected incorporating the 36-item Short Form Health Survey (SF-36), the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0), and the Stroke Impact Scale 3.0 (SIS 3.0), the application of the standardized reporting based on common metrics is demonstrated. RESULTS A subset of items from the three tools linked to common chapters of the ICF (d4 Mobility, d5 Self-care and d6 Domestic life), were entered as "super items" into the Rasch model. Good fit was achieved with no residual local dependency and a unidimensional metric. A transformation table allows for comparison between scales, and between a scale and the reporting common metric. CONCLUSIONS Being able to report functioning information collected with commonly used clinical data collection tools with ICF-based common metrics enables clinicians and researchers to continue using their tools while still being able to compare and aggregate the information within and across tools.
Early Expressive Language Skills Predict Long-Term Neurocognitive Outcomes in Cochlear Implant Users: Evidence from the MacArthur-Bates Communicative Development Inventories.

PURPOSE The objective of the present article was to document the extent to which early expressive language skills (measured using the MacArthur-Bates Communicative Development Inventories [CDI; Fenson et al., 2006]) predict long-term neurocognitive outcomes in a sample of early-implanted prelingually deaf cochlear implant (CI) users. METHOD The CDI was used to index the early expressive language skills of 32 pediatric CI users after an average of 1.03 years (SD = 0.56, range = 0.39-2.17) of CI experience. Long-term neurocognitive outcomes were assessed after an average of 11.32 (SD = 2.54, range = 7.08-16.52) years of CI experience. Measures of long-term neurocognitive outcomes were derived from gold-standard performance-based and questionnaire-based assessments of language, executive functioning, and academic skills. RESULT Analyses revealed that early expressive language skills, collected on average 1.03 years post cochlear implantation, predicted long-term language, executive functioning, and academic skills up to 16 years later. CONCLUSION These findings suggest that early expressive language skills, as indexed by the CDI, are clinically relevant for identifying CI users who may be at high risk for long-term neurocognitive delays and disturbances.
Impacts of Wear and Geometry Response of the Cutting Tool on Machinability of Super Austenitic Stainless Steel

This paper presents a study of tool wear and geometry response when machinability tests were applied under milling operations on the Super Austenitic Stainless Steel alloy AL-6XN. Eight milling trials were executed under two cutting speeds, two feed rates, and two depths of cuts. Cutting edge profile measurements were performed to reveal response of cutting edge geometry to the cutting parameters and wear. A scanning electron microscope (SEM) was used to inspect the cutting edges. Results showed the presence of various types of wear such as adhesion wear and abrasion wear on the tool rake and flank faces. Adhesion wear represents the formation of the built-up edge, crater wear, and chipping, whereas abrasion wear represents flank wear. The commonly formed wear was crater wear. Therefore, the optimum tool life among the executed cutting trails was identified according to minimum length and depth of the crater wear. The profile measurements showed the formation of new geometries for the worn cutting edges due to adhesion and abrasion wear and the cutting parameters. The formation of the built-up edge was observed on the rake face of the cutting tool. The microstructure of the built-up edge was investigated using SEM. The built-up edge was found to have the austenite shear lamellar structure which is identical to the formed shear lamellae of the produced chip.
Primary cutaneous anaplastic large cell lymphoma

Primary cutaneous anaplastic large cell lymphoma (PC‐ALCL) is a CD30+ lymphoproliferative disorder (LPD) of the skin with a relatively good prognosis in the absence of high‐stage disease. CD30+ LPDs comprise approximately 25%‐30% of primary cutaneous lymphomas and as a group represent the second most common clonal T‐cell neoplasm of the skin behind mycosis fungoides. Diagnosis of PC‐ALCL relies strongly on clinicopathologic correlation given the potential morphologic, clinical and molecular overlap with the other cutaneous CD30+ LPD, lymphomatoid papulosis, and more aggressive hematolymphoid neoplasms.
Cryptic Diversity of the Tetraclita squamosa Complex (Crustacea: Cirripedia) in Asia: Description of a New Species from Singapore

T. kuroshioensis by more than 19%, 10%, and 11% divergences in the COI, 12S rRNA, and ITS1 sequences, respectively. These values are much higher than those within each taxon (< 1.5% in the most variable COI sequence), revealing that they are genetically distinct. The clear genetic and morphological differences from both T. squamosa and T. kuroshioensis indicate that T. squamosa from Singapore represents a new species of Tetraclita. Tetraclita squamosa in the Indo-West Pacific region is a cryptic species complex with high morphological and genetic diversity. Given the relatively restricted areas investigated to the present, it is likely that more species await discovery in Southeast Asia, Australia, and the Indian Ocean. http://zoolstud.sinica. edu.tw/Journals/46.1/46.pdf
Effect of the proximal anastomosis site on mid-term radial artery patency in off-pump coronary artery bypass†

OBJECTIVES The purpose of this study was to evaluate mid-term patency and clinical outcomes according to the proximal anastomosis site after off-pump coronary artery bypass using the radial artery (RA). METHODS From January 2001 to December 2015, 1124 patients who underwent isolated off-pump coronary artery bypass using the RA were reviewed and divided into 2 groups: the composite Y-graft (n = 1014, Y group) and aortocoronary graft (n = 110, Aorta group). Graft patency was assessed by computed tomography or coronary angiography. RESULTS Patients receiving Y-grafts had a greater number of RA anastomoses (1.79 ± 0.68 per patient vs 1.40 ± 0.51 per patient, P < 0.001), more sequential grafts (55.6% vs 37.3%, P < 0.001) and a higher incidence of total arterial revascularization (77.9% vs 54.5%, P < 0.001). Postoperative graft patency at a mean of 3.1 ± 3.5 years was assessed in 1944 distal RA anastomoses (Y group: 1811, Aorta group: 133). No significant differences were observed in RA graft patency rate (P = 0.705), overall survival (P = 0.987) and major cardiac event-free survival (P = 0.830) between groups. Multivariable analysis demonstrated that the independent predictors of graft occlusion were age [hazard ratio (HR) 1.025, confidence interval (CI) 1.007-1.044; P = 0.007], female gender (HR 1.391, CI 1.007-1.924; P = 0.047), target of the right coronary artery territory (HR 2.135, CI 1.347-3.382; P = 0.001) and target vessel stenosis ≥90% (HR 0.478, CI 0.291-0.785; P = 0.004). The proximal anastomosis site was not significantly associated with graft occlusion (P = 0.705). CONCLUSIONS When target vessel territory and stenosis are appropriately considered, the RA as a secondary conduit can be effectively used for myocardial revascularization, regardless of the proximal anastomosis site.
A qualitative evaluation of a learning dashboard to support advisor-student dialogues

This paper presents an evaluation of a learning dashboard that supports the dialogue between a student and a study advisor. The dashboard was designed, developed, and evaluated in collaboration with study advisers. To ensure scalability to other contexts, the dashboard uses data that is commonly available at any higher education institute. It visualizes the grades of the student, an overview of the progress through the year, his/her position in comparison with peers, sliders to plan the next years and a prediction of the length of the bachelor program for this student in years based on historic data. The dashboard was deployed at KU Leuven, Belgium and used in September 2017 to support 224 sessions between students and study advisers. We observed twenty of these conversations. We also collected feedback from 101 students with questionnaires. Results of our observations indicate that the dashboard primarily triggers insights at the beginning of a conversation. The number of insights and the level of these insights (factual, interpretative and reflective) depends on the context of the conversation. Most insights were triggered in conversations with students doubting to continue the program, indicating that our dashboard is useful to support difficult decision-making processes.
Transmission Line Modeling of Scattering From a Linear Conductor Near the Surface of the Ground

Applied modeling of electromagnetic interactions with linear conductors is essential to advance near-earth sensing devices and integrated signal processing algorithms. This paper describes the development of a novel analytical transmission line (TL) model and its subsequent comparison with a method of moments simulation. The TL model predicts electromagnetic scattering by a linear conductor of finite length that is near lossy ground, here assumed to be a homogeneous conducting half-space. Our model uniquely combines the following: the effect of surface waves on the fields, the proximity of the air–ground interface on wave propagation along the conductor, orthogonal electric dipole exciter polarizations, and the role of an insulating layer on the conductor. It is shown that the TL approach is accurate and offers advantages such as fast computation time, physical insight into the scattering process, and potential for embedded signal processing.
The practice of essential nutrition actions in healthcare deliveries of Shebedino District, South Ethiopia

The essential nutrition actions explain nutrition through life cycle approach addressing women’s nutrition during pregnancy and lactation, optimal infant and young children feeding, nutritional care for sick children and control of anemia, iodine and vitamin A deficiencies. Essential nutrition action has been implemented and resulted in positive outcome in less developed countries. However, the status of practice and associated factors were not studied in Ethiopia. Thus, institution-based cross-sectional study was conducted to assess the practice of essential nutrition actions in healthcare deliveries of Shebedino District, South Ethiopia. Quantitative data were collected though face-to-face interview with health workers and triangulated with data obtained through in-depth interview with health managers in the district and non-participatory observation of client-provider interaction in health facilities. Data were analyzed using SPSS16.0 software. Descriptive and logistic regression analyses were undertaken. The study revealed that 61 (56.0%) health workers practiced essential nutrition actions. Seventy one (65.1%) health workers were trained on essential nutrition actions. The practice of essential nutrition actions was associated with career structure of the health workers (AOR = 6.79, 95%CI: 2.31, 19.98), essential nutrition actions knowledge of health workers (AOR = 6.87, 95%CI: 2.11, 21.51) and availability of monthly nutrition related report form (AOR = 4.95, 95%CI: 1.46, 16.81). The practice of essential nutrition actions was low. The factors affecting the practice were inadequate training and knowledge of essential nutrition actions, career structure of the health workers and availability of monthly report form. Training should be provided for health workers on essential nutrition actions; moreover, essential nutrition actions indicators should be included in monthly report forms of the health institutions.