Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase III comparative study of vinorelbine combined with doxorubicin versus doxorubicin alone in disseminated metastatic/recurrent breast cancer: National Cancer Institute of Canada Clinical Trials Group Study MA8.

PURPOSE This phase III study was performed to determine the superiority of doxorubicin (DOX) and vinorelbine (VNB) (arm 1) versus DOX alone (arm 2) in metastatic breast cancer (MBC) for overall survival (OS), time to treatment failure (TTF), toxicity, and quality of life (QOL). PATIENTS AND METHODS Three hundred three patients were randomized to DOX 50 mg/m(2) intravenously (IV) on day 1 and VNB 25 mg/m(2) IV on days 1 and 8 (arm 1) or DOX 70 mg/m(2) IV on day 1 (arm 2). Both regimens were given every 3 weeks until a cumulative DOX dose of 450 mg/m(2). After 16 of the first 65 randomized patients experienced febrile neutropenia (FN), the doses were reduced to DOX 40 mg/m(2) on day 1 and VNB 20 mg/m(2) on days 1 and 8 versus DOX 60 mg/m(2) on day 1. Eligible patients were vinca alkaloid and anthracycline naive. Chemotherapy was first-line or second-line for MBC. RESULTS Three patients were ineligible. Thus, 300 patients were assessable for toxicity and to determine time to disease progression (TTP), TTF, and OS. Two hundred eighty-nine patients were assessable for response, and 99 responders were assessable for response duration (RD). The response rates, QOL, and median RD, TTP, and TTF were not significantly different between the arms. Median OS was 13.8 months for arm 1 versus 14.4 months for arm 2 (P =.4). Grade 3 or 4 granulocytopenia was equivalent in both arms but more grade 3/4 neurotoxicity, mild venous toxicity, and FN were seen on arm 1. CONCLUSION The survival with DOX and VNB is not superior to DOX alone in MBC.
Recognition of apoptotic cells by human macrophages: inhibition by a monocyte/macrophage‐specific monoclonal antibody

Cells undergoing death by apoptosis are rapidly engulfed by phagocytes in vivo, a highly efficient process which prevents leakage of potentially dangerous intracellular contents from dying cells to neighboring tissue. We have tested a panel of monoclonal antibodies (mAb) specifying a range of human monocyte/macrophage surface antigens for their capacity to inhibit the in vitro recognition of apoptotic cells by human peripheral blood monocyte‐derived macrophages. The results identify the antigen defined by the 61D3 mAb, a widely‐used marker of monocyte/macrophage lineage cells, as an important mediator of apoptotic cell recognition. In our system, apoptotic, but not viable, cells were recognized by the cultured macrophages and 61D3 was found to inhibit the recognition of all apoptotic cell types tested, including Ca2+ ionophore‐treated or growth factor‐depleted B and T lymphocyte lines, tonsillar germinal center B cells, irradiated peripheral blood lymphocytes and senescing neutrophils. Furthermore, the apoptotic cell recognition pathway specified by 61D3 could be distinguished from that involving the macrophage αvβ3 vitronectin receptor which has been shown previously to play an important role in the recognition of apoptotic cells. These results provide further evidence that the mechanisms underlying rapid clearance of apoptotic cells involve multiple phagocyte receptors.
Measuring flourishing: The impact of operational definitions on the prevalence of high levels of wellbeing

The epidemiology of flourishing is an important research topic prompting international interest in its psychometric assessment. But the need to measure human feelings and functioning at the population level has resulted in the creation of a multitude of different conceptual frameworks of flourishing: a term now commonly used to describe high levels of subjective wellbeing. Not only do different researchers theorise and conceptualise flourishing in different ways, but also the categorical diagnosis of flourishing is dependent upon the various combinations of components, and researcher-determined thresholds, used in each operationalization. The multiplicity of approaches is potentially limiting the usefulness of the resultant epidemiology. This paper comprises two parts: Part 1 identifies four operationalizations of flourishing in the psychology literature and reviews their psychometric properties and utility; Part 2 investigates the impact of operational definition on the prevalence of flourishing using the Sovereign Wellbeing Index survey, a sample of 10,009 adult New Zealanders, and reports substantial variation in prevalence rates according to the four different operationalizations: Huppert and So (24%), Keyes (39%), Diener et al. (41%) and Seligman et al. (47%). Huppert and So’s model was the only one of the four to require endorsement of one particular variable, making it the most stringent criterion for flourishing, while the other three were more flexible in their categorisation. Cross-tabulation analysis indicated strong agreement between our replications of Keyes and Seligman et al.’s models (81%), and between Diener et al. and Seligman et al.’s models (80%). Agreement between Seligman, and Huppert and So’s, operationalizations was moderate (74%). Taken together, and in line with recent OECD recommendations, our findings reinforce the need for greater international collaboration and conceptualisation consensus when measuring flourishing. In the absence of any published empirical research investigating perceptions of flourishing among laypersons, a prototype analysis investigating alignment between lay and academic conceptualisations of flourishing is recommended.
Images of Circular Time and Spiral Repetition: The Generative Life Cycle Model

The purpose of this article is to propose the Generative Life Cycle Model (GLCM) in two versions. The ecological version of the GLCM focuses on the cyclical images of successive generations beyond an individual’s life and death within ecological contexts. The spiral version of the GLCM is represented by the repeated spirals with variants, and is characterized by the multiple time concepts and the generative processes of life and death. The linear time concept, represented as a horizontal arrow, reflects an individual’s life characterized by a single stream of time from birth to death. Certainly, each individual is unique and can never be reproduced. Nevertheless, people can image and narrate stories in which their lives are regarded as being reproducible. These life stories based on repetition, reproduction, recovery and renewal have significant meanings for generative connections from past generations to future generations, and for the imaginations of continuities of multiple human lives within different historical eras
Emotion Regulation and its Influence on Body-Related Distress in Overweight Women

Overweight and obese individuals are at greater risk for the development of a major depressive disorder. A main factor contributing to negative affect in obese women is body-related worrying. Given the potential benefits of various emotion regulation (ER) strategies in the modification of negative affect, the aim of the present study was to test whether experimentally-induced body dissatisfaction can be modified by ER strategies in obese women. Body dissatisfaction was experimentally induced in a group of 37 obese women using model pictures. Following this, participants were randomly assigned to two different ER strategies: rumination on present emotions and thoughts, or acceptance of whatever thoughts and feelings come up. Weight and appearance satisfaction, distress about body feelings and mood were assessed both prior to, immediately after, and 4 min after the induction. Psychophysiological parameters were assessed continuously. The main results reveal that after the use of ER strategies, weight and appearance satisfaction returned to baseline levels. However, in the rumination condition, distress about body feelings remained above and mood below baseline. In the acceptance condition distress and mood returned to baseline levels. The results are discussed in terms of the usefulness of ER strategies with regard to reducing body-related distress.
Contributions of Music Video Exposure to Black Adolescents’ Gender and Sexual Schemas

Although music videos feature prominently in the media diets of many adolescents, little is known of their impact on viewers’ conceptions of femininity and masculinity. Accordingly, this study examines the impact of both regular and experimental music video exposure on adolescent viewers’ conceptions about gender. Across two testing sessions, 152 African American high school students completed survey measures assessing their regular media usage and gender role attitudes, and later they were exposed to either four stereotypical music videos or four nonstereotypical music videos and responded to additional measures examining their attitudes about gender. As expected, more frequent music video viewing was associated with more traditional gender role attitudes and with assigning greater importance to specific stereotypical attributes. Similarly, students exposed to videos laden with gender stereotypes expressed more traditional views about gender and sexual relationships than did those who had viewed less stereotypical content.
Effects on the Laughter Score, Cortisol and Immunoglobulin of Laughter Therapy in Middle Aged Women

Purpose: In this study, the effects of laughter therapy on a laughter index, cortisol and immunoglobulin of middle aged women were examined. Methods: A quasi-experimental nonequivalent control group pre/post-test design were used. The participants (n = 54) included 27 in the experimental group and 27 in the control group. The data were collected from February through March of 2013. The experimental group participated in laughter therapy for 40 minutes per session, five times a week for a period of 2 weeks. The tool was used to measure pre/post-test laughter index, cortisol and immunoglobulin of middle aged women. Results: The results showed that laughter therapy was effective in increasing the laughter index (p < .001), and immunoglobulin IgA (p < .001), IgG (p < .001), and IgM (p = .010). Also, the stress hormone, cortisol of middle aged women decreased but non-significantly (p = .158). Conclusion: The result of the study indicates that laughter therapy may have an influence on nursing intervention and treatment effects to improve the laughter index and immunoglobulin of middle aged women.
Structured Variation in Codeswitching: Towards an Empirically Based Typology of Bilingual Speech Patterns

This paper aims to accomplish two things: first, to develop precise criteria to establish profiles for bilingual speech, following the typology of insertion, alternation and congruent lexicalisation developed in Muysken (2000); and second, to test these criteria on specific data sets. A first set involves Welsh–English bilingual data analysed by Deuchar, a second set comprises Tsou–Mandarin Chinese data collected and analysed by Sung-Lan Wang, and a third set involves Taiwanese–Mandarin Chinese data, also collected and analysed by Sung-Lan Wang. We conclude that it is indeed possible to establish more precise quantitative profiles which capture the intuition that different data sets show different codeswitching properties, but that there are a number of conceptual and methodological issues that require further investigation.
Faria populations The early spread and epidemic ignition of HIV-1 in human

, 56 (2014); 346 Science et al. Nuno R. Faria populations The early spread and epidemic ignition of HIV-1 in human This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): October 2, 2014 www.sciencemag. org (this information is current as of The following resources related to this article are available online at http://www.sciencemag. org/content/346/6205/56.full. html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag. org/content/suppl/2014/10/01/346.6205. 56.DC1. html can be found at: Supporting Online Material http://www.sciencemag. org/content/346/6205/56.full. html#related found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag. org/content/346/6205/56.full. html#ref-list-1 , 30 of which can be accessed free: cites 78 articles This article http://www.sciencemag. org/cgi/collection/medicine Medicine, Diseases subject collections: This article appears in the following
On the local existence of the free-surface Euler equation with surface tension

Here σ > 0 is the surface tension, while H represents twice the mean curvature of the boundary ∂ (t). Problems related to local or global existence of solutions of free surface evolution under the Euler flow, with or without surface tension, have attracted considerable attention in the last decades. For both cases different approaches have been developed; however, the search is still in progress for the lowest regularity spaces where the existence or uniqueness of solutions hold. For the history of both problems, cf. [2,17,32] and references therein. While in the zero surface tension case the problem is known to be unstable, and thus the RayleighTaylor stability condition has to be imposed, this is not necessary when the surface tension is nonzero since the surface tension provides a stabilizing effect close to the boundary.
STOCHASTIC VARIABILITY IN X-RAY EMISSION FROM THE BLACK HOLE BINARY GRS 1915+105

We examine stochastic variability in the dynamics of X-ray emission from the black hole system GRS 1915+105, a strongly variable microquasar commonly used for studying relativistic jets and the physics of black hole accretion. The analysis of sample observations for 13 different states in both soft (low) and hard (high) energy bands is performed by flicker-noise spectroscopy (FNS), a phenomenological time series analysis method operating on structure functions and power spectrum estimates. We find the values of FNS parameters, including the Hurst exponent, flicker-noise parameter, and characteristic timescales, for each observation based on multiple 2500 s continuous data segments. We identify four modes of stochastic variability driven by dissipative processes that may be related to viscosity fluctuations in the accretion disk around the black hole: random (RN), power-law (1F), one-scale (1S), and two-scale (2S). The variability modes are generally the same in soft and hard energy bands of the same observation. We discuss the potential for future FNS studies of accreting black holes.
An Exploration of the Experiential Nature of Boutique Accommodation

There has been increased attention given in the tourism literature to the experiential consumption of tourism. This article addresses the lack of attention in previous studies to the experiential nature of accommodation products, especially with regard to boutique or specialist accommodation. Attention to tourists’ experiences with accommodation is essential for determining guest satisfaction and the personal benefits that guests derive from their stay. In-depth interviews with 19 hosts and 30 guests at boutique accommodation establishments in Nelson in the South Island of New Zealand highlighted the emotive aspects of the experiences gained by guests and revealed five key experiential dimensions that are seen as important to the success of boutique accommodation product: unique character, personalized, homely, quality, and value added. Ways in which the experiential qualities offered by boutique accommodation are perceived to differ from that provided by other traditional and specialist types of accommodation are also discussed.
British Population and Society in 2025: Some Conjectures

The paper examines three aspects of demographic change and conjectures about their wider impact on British society. Two features of fertility behaviour are highlighted. The first deals with ethnic variations and the likely continuation of high fertility rates amongst women of South Asian origin. The second involves the continued bifurcation between career women and those for whom motherhood remains a central life project. International migration is also assessed and the contradictions within the `Fortress Britain' strategy exposed. Britain will continue to receive migrants from overseas and British society will become increasingly multi-ethnic. The paper also examines the tensions between an increasingly ageing population and the development of increased ethnic and cultural diversity. The paper concludes with some implications of these changes for the discipline of sociology itself.
Spinning Straw into Gold: the Tenuous Strategy, Funding, and Financial Performance Linkage

This study investigates relationships between strategic process elements, sources of funding, and the growth and financial strategies pursued by 31 nonprofit social service organizations. Organizations were categorized on the basis of their achievement of a balanced budget and targeted funding goals. Based on these criteria, the most successful firms (a) maintained or developed a strong relatedness in program offerings; (b) were financially oriented, with a diverse funding base, and with fund-raising efforts targeting a specific source category for increase; (c) emphasized marketing; and (d) principally sought growth through increased client usage of current offerings. Less successful organizations appeared to lack key strategic management attributes regarding direction or execution.
The Distal Sequence Element of the Selenocysteine tRNA Gene Is a Tissue-Dependent Enhancer Essential for Mouse Embryogenesis

ABSTRACT Appropriate expression of the selenocysteine tRNA (tRNASec) gene is necessary for the production of an entire family of selenoprotein enzymes. This study investigates the consequence of disrupting an upstream enhancer region of the mouse tRNASec gene (Trsp) known as the distal sequence element (DSE) by use of a conditional repair gene targeting strategy, in which a 3.2-kb insertion was introduced into the promoter of the gene. In the absence of DSE activity, homozygous mice failed to develop in utero beyond embryonic day 7.5 and had severely decreased levels of selenoprotein transcript. Cre-mediated removal of the selection cassette recovered DSE regulation of Trsp, restoring wild-type levels of tRNASec expression and allowing the generation of viable rescued mice. Further analysis of targeted heterozygous adult mice revealed that the enhancer activity of the DSE is tissue dependent since, in contrast to liver, heart does not require the DSE for normal expression of Trsp. Similarly, in mouse cell lines we showed that the DSE functions as a cell-line-specific inducible element of tRNASec. Together, our data demonstrate that the DSE is a tissue-dependent regulatory element of tRNASec expression and that its activity is vital for sufficient tRNASec production during mouse embryogenesis.
Need for approval, children's sharing behavior, and reciprocity in sharing.

2 questions were investigated about the sharing behavior of children in the course of their interaction with other children: the relation between need for approval and sharing, and reciprocity in sharing. A significant negative relation was found between Ss' (the givers) scores on a measure of need for approval and both the amount of candy they shared and the amount they ate in the presence of another child (the receiver). Children with strong need for approval were "inactive" in relation to the candy in the presence of the other child, presumably inhibited by fear of disapproval. Reciprocity was shown by a positive relation between the number of candies shared and the subsequent sharing of the (use of a crayon by the receiver. Moreover, the difference between the amount of candy givers ate and the amount they shared was significantly related to the receiver's sharing of the crayon. Receivers seemed to respond to the fairness or unfairness of the givers' behavior, retaliating for obvious selfishness. Finally, children's liking for each other also influenced sharing behavior.
Sense of Sensing: From Data to Informed Decisions for the Built Environment

There is currently an explosion of research on microsensor and wireless network technology, and methods of discerning structural state from such data. Besides the inherent interest in such fascinating technology, the question remains as to why an owner, operator, or user of the built environment should care. The construction industry is now adopting new types of contracting practice. Previously the contractor simply implemented a given design, but the current trend is for clients to commission certain performance requirements to be met with performance-based design. The emphasis of the industry is becoming the delivery of certain structural behavior states rather than simply building to a client’s set plans. The contracting process becomes the determination of the performance criteria, and delivery becomes a long-term fulfillment of these criteria. This can only take place if the performance states can be measured, and the measurement utilized in a decision-making process. The tools needed for both the ev.
An Exploratory Study of Seventeen Sexually Open Marriages1

Extensive lifestyle and attitudinal data were collected from eleven couples in Florida and six couples in Kansas who described their marriage styles as sexually open: all outside relationships were with the knowledge of the spouse, and independent functioning with satellite partners was preferred rather than an exchange arrangement as in swinging. Other common characteristics were noted: emotional involvement with outside partners was common and generally accepted; non‐spouse partners maintained separate residences; prospective partners did not have to be selected from certain predefined populations; and in addition to sexual pleasure there was emphasis on social and intellectual sharing and the psychological well‐being of all persons involved. Some sexual behavior patterns, role structures, ground rules, benefits, and stresses of this marriage style are explicated.
Fear, the School Organization, and Teacher Evaluation

Fear can be conceptualized differently as experienced by those inside and outside the school organization. Internally, participants respond to fear in a politics of maintenance aimed toward protection against anticipated job loss(es). This article examines internal organizational participants' fear, with particular attention to teachers' fear of being evaluated. It is argued that the cellular organization of teaching contributes to fear, as do certain existing conflicts in evaluation. For example, teachers fearing a summative evaluation may be less than forthcoming about their performance shortcomings and/or goals. An analysis of fear in teacher evaluation should take into account (a) teacher controllability of teaching and its evaluation and (b) principals' preference for evaluation rigidity. In environments compromised by fear, for example, administrators might restrict information in teacher evaluation. Reform directions such as union participation and altering the adversarial tone of evaluation may improve evaluation by more fully developing the skills desired in teaching.
Introduction: The Elusive Idea of Utopia

This introductory article discusses the contributions to this number in the light of some general issues arising out of recent writing on utopia. It notes the wide variety of views on the question of definition of utopia, ranging from the anti-utopian dismissal of it as totalitarianism to a broad and flexible vehicle of desire. It traces the shifting accents of utopia consequent on the move beyond modernity - a shift from time to space and from content to process. Only a flexible approach reflected in the variety of articles in this collection can offer glimpses of the most elusive utopia, the transcendence of loss and longing.