Miracle-dz/UniFAR-FTUs huggingface dataset:
Complete and partial uterine perforation and embedding following insertion of intrauterine devices. I. Classification, complications, mechanism, incidence, and missing string.

This report of complete and partial uterine perforation and embedding following IUD insertion is based on a review of the pertinent literature of the past 15 years. An analysis of 356 cases reported in the literature during this time are included. A classification is proposed based on the distinction between complete and partial perforation. Of all perforations of the uterus, be they fundal, lower segmental, or upper cervical, the completely perforated IUD is the type most often encountered, most commonly described, most readily recognized, and most easily removed. To differentiate between perforated IUDs, 3 anatomical compartments are postulated. For the purposes of discussion, the endometrial and serosal layers of the uterus are disregarded, leaving only the myometrium as its truly essential feature. Compartment 1 is the uterine cavity; compartment 2, the myometrium; and compartment 3, the peritoneal cavity. Completely perforated and, less often, partially perforated IUDs may intrude upon neighboring viscera, particularly the intestinal tract, resulting frequently in seriously ill patients who require intensive treatment including intestinal surgery. In the review of 356 case reports, such special situations arose in 53 cases, or 15%. Of the 53 reported cases, 41 concerned the intestinal tract. There were 6 cases in which the IUD was in the bladder. In 1 case, the perforation had been partial (Lippes loop) and, in 5 cases, complete (4 Lippes loop and 1 Dalkon shield). There were 3 cases in which the uterus was involved under special circumstances. There were 5 cases in which death occurred in relation to uterine perforation by IUD. It is probable that, of the various factors responsible for uterine perforation by IUDs, the most important are the consistency and flexion of the uterus, the type and the rigidity of the IUD and its inserter, and the amount of force exerted at insertion, with the result that the IUD stops at a certain point rather than proceeding to complete perforation. If the IUD does not penetrate beyond the uterine wall, i.e., if it is type 1-2 or type-2 perforation, negative intraabdominal pressure does not obtain. If the IUD had penetrated beyond the uterine wall, the theoretical possibility exists for further progression to type 3 perforation more readily than in the type 1-2 or type 2 perforation. In this review of 356 cases, 352 cases were suitable for analysis. Of these there were 53 unusual complications involving the intestinal tract, bladder, and so forth. There were 299 cases of simple perforation involving the uterus only, of which 255 were complete and 44 were partial. The mechanism of cervical perforation appears to depend on the presence of an IUD with a dependent limb in its design. Embedding, diagnosis, and the problem of the missing string are reviewed.
Synthesising verified access control systems in XACML

The <i>eXtensible Access Control Markup Language</i> (XACML) was proposed by the OASIS committee to be used as a standard language in e-business [6]. However, policy files written in XACML are hard to read and analyse directly. In this paper, we present a tool which generates verified XACML scripts from access control system descriptions in simple but expressive language proposed in [3], which admits algorithmic verification of access control systems against appropriately formalised policies. This allows the generation of XACML scripts for systems that can be formally verified to be implementing the relevant policies.
Allergenicity suppression in natural latex surgical gloves

By a revised manufacturing process we aimed to obtain latex surgical gloves without immediate allergenicity, and also to determine a simple physical technique by which to estimate this allergenicity. Five glove samples were evaluated for allergenicity by physical and biochemical methods and by skin texts at the University Allergy Centre, Three groups of allergic patients with documented anaphylaxis to surgical gloves, positive skin test to latex extract and specific IgE to latex (RAST Pharmacia & class II), volunteered for the study. The protein content, the in vitro allergenic potency of glove supernatants (RAST inhibition) and the skin test results with glove supernatants were lower in washed gloves than in non‐washed samples (P < 0.02 to P < 0.009). The supplementary effect of glove sterilization at 120°C (for 1 h in saturated steam) was obvious. The protein content became undetectable in four of the five glove supernatants, and skin tests results with sample supernatants were decreased (M±SEM = 0.68±0.29 mm vs 3.06±0.61 mm with non‐sterilized gloves), P < 0.009 by Wilcoxon test. With the Spearman test there was a significant correlation (P= 0.029) between the mean wheal size, obtained with supernatants (Groups 1 and 2) and electrical conductivity. Skin tests through pieces of gloves randomly distributed and coded were decreased by sterilization: 0.66±0.25 mm vs 2.86±00,45 mm, p 0.0001. Thus, it is possible to decrease glove allergenicity by washing them after mould forming and then sterilizing with steam. Electrical conductivity may be a simple parameter for revealing allergenicity.
Luminal STAT5 mediates H2AX promoter activity in distinct population of basal mammary epithelial cells

Deregulated STAT5 activity in the mammary gland causes parity-dependent tumorigenesis. Epithelial cell cultures transfected with constitutively active STAT5 express higher levels of the histone H2AX than their non-transfected counterparts. Higher H2AX expression may be involved in tumorigenesis. Here, we aimed to link high STAT5 activity to H2AX–GFP expression by looking for distinct types of mammary cells that express these proteins. In vitro and in transgenic mice, only 0.2 and 0.02%, respectively, of the cells expressed the H2AX–GFP hybrid gene. Its expression correlated with that of the endogenous H2AX gene, suggesting that detectable H2AX–GFP expression marks high levels of H2AX transcript. Methylation of the H2AX promoter characterized non-GFP-expressing H2AX–GFP cells and was inversely correlated with promoter activity. Administration of 5-azacytidine increased H2AX promoter activity in an activated STAT5-dependent manner. In transgenic mice, H2AX–GFP expression peaked at pregnancy. The number of H2AX–GFP-expressing cells and GFP expression decreased in a Stat5a-null background and increased in mice expressing the hyperactivated STAT5. Importantly, H2AX–GFP activity was allocated to basal mammary cells lacking stem-cell properties, whereas STAT5 hyperactivity was detected in the adjacent luminal cells. Knockdown of RANKL by siRNA suggested its involvement in signaling between the two layers. These results suggest paracrine activation of H2AX via promoter demethylation in specific populations of basal mammary cells that is induced by a signal from neighboring luminal cells with hyper STAT5 activity. This pathway provides an alternative route for the luminally confined STAT5 to affect basal mammary cell activity.
Head-turning asymmetries during kissing and their association with lateral preference

A head-turning bias to the right side is one of the earliest functional asymmetries in human development and is already present during the final weeks of gestation. To test whether head-turning preference is related to other lateral preferences in adults, kissing behaviour of participants towards a symmetrical doll was observed to assess their spontaneous head-turning preference. Additionally, participants’ individual handedness, footedness, and eye preference were determined using questionnaires. A significant difference in handedness and footedness, but not eye preference, was found between left- and right-kissers, with right-kissers showing a stronger right-sided bias than left-kissers. These results support the assumption that the head-turning bias in humans may be able to induce or enhance other asymmetries of perception and action.
Imperfect Duplicate Insertions Type of Mutations in Plasmepsin V Modulates Binding Properties of PEXEL Motifs of Export Proteins in Indian Plasmodium vivax

Introduction Plasmepsin V (PM-V) have functionally conserved orthologues across the Plasmodium genus who's binding and antigenic processing at the PEXEL motifs for export about 200–300 essential proteins is important for the virulence and viability of the causative Plasmodium species. This study was undertaken to determine P. vivax plasmepsin V Ind (PvPM-V-Ind) PEXEL motif export pathway for pathogenicity-related proteins/antigens export thereby altering plasmodium exportome during erythrocytic stages. Method We identify and characterize Plasmodium vivax plasmepsin-V-Ind (mutant) gene by cloning, sequence analysis, in silico bioinformatic protocols and structural modeling predictions based on docking studies on binding capacity with PEXEL motifs processing in terms of binding and accessibility of export proteins. Results Cloning and sequence analysis for genetic diversity demonstrates PvPM-V-Ind (mutant) gene is highly conserved among all isolates from different geographical regions of India. Imperfect duplicate insertion types of mutations (SVSE from 246–249 AA and SLSE from 266–269 AA) were identified among all Indian isolates in comparison to P.vivax Sal-1 (PvPM-V-Sal 1) isolate. In silico bioinformatics interaction studies of PEXEL peptide and active enzyme reveal that PvPM-V-Ind (mutant) is only active in endoplasmic reticulum lumen and membrane embedding is essential for activation of plasmepsin V. Structural modeling predictions based on docking studies with PEXEL motif show significant variation in substrate protein binding of these imperfect mutations with data mined PEXEL sequences. The predicted variation in the docking score and interacting amino acids of PvPM-V-Ind (mutant) proteins with PEXEL and lopinavir suggests a modulation in the activity of PvPM-V in terms of binding and accessibility at these sites. Conclusion/Significance Our functional modeled validation of PvPM-V-Ind (mutant) imperfect duplicate insertions with data mined PEXEL sequences leading to altered binding and substrate accessibility of the enzyme makes it a plausible target to investigate export mechanisms for in silico virtual screening and novel pharmacophore designing.
Flux Densities and Radio Polarization Characteristics of Two Vela-like Pulsars

We report on dual-frequency radio polarimetry observations of two young, energetic pulsars, PSRs J0940-5428 and J1301-6305. These were among the first Vela-like pulsars discovered in the Parkes multibeam survey. We conducted observations of these pulsars with the Australia Telescope Compact Array (ATCA) at center frequencies of 1384 and 2496 MHz using pulsar gating while preserving full Stokes parameters. After correcting for bandwidth depolarization, we measured polarization characteristics, flux densities, and rotation measures for these pulsars. The spectral indices derived from the ATCA data are shallow but still consistent with values seen for pulsars of this type. The rotation measures for both pulsars are consistent with those reported recently using data from the Parkes telescope, and both pulsars have highly linearly polarized pulse profiles at both 1384 and 2496 MHz. Our results support a previously noted correlation between a high degree of linear polarization, shallow spectral index, and large spin-down luminosity.
A Platform for Learning Internet of Things

This paper presents a model for conducting Internet of Things (IoT) classes based on a web-service oriented cloud platform. The goal of the designed model is to provide university students with knowledge about IoT concepts, possibilities, and business models, and allow them to develop basic system prototypes using general-purpose microdevices and a cloud and service infrastructure. The model was based on a cloud infrastructure deployed at the E-Business Department at the Belgrade University, and some implementation details are given. The model was tested and evaluated
Author ' s personal copy Market impacts of a multiyear mechanical fuel treatment program in the U

We describe a two-stage model of global log and chip markets that evaluates the spatial and temporal economic effects of government-subsidized fire-related mechanical fuel treatment programs in the U.S. West and South. The first stage is a goal program that allocates subsidies according to fire risk and location priorities, given a budget and a feasible, market-clearing market solution. The second stage is a quadratic welfare maximization spatial equilibriummodel of individual State and global product markets, subject to the fuel treatment allocation. Results show that the program enhances timber market welfare in regions where treatments occur and globally but has an overall negative economic impact, once fuel treatment program costs are included. The overall cost of a mechanical fuel treatment program, when considering timber market welfare, transport costs, treatment costs, and timber receipts, exceeds $1000 per acre, implying that the long run fire effects and ecosystem net benefits of a treatment programwould need to exceed this figure in order to justify widespread implementation. Published by Elsevier B.V.
Receiver Concepts and Resource Allocation for OSC Downlink Transmission

Voice services over Adaptive Multi-user channels on One Slot (VAMOS) has been standardized as an extension to the Global System for Mobile Communications (GSM). The aim of VAMOS is to increase the capacity of GSM, while maintaining backward compatibility with the legacy system. To this end, the Orthogonal Sub-channels (OSC) concept is employed, where two Gaussian minimum-shift keying (GMSK) signals are transmitted in the same time slot and with the same carrier frequency. To fully exploit the possible capacity gain of OSC, new receiver concepts are necessary. In contrast to the base station, where multiple antennas can be employed, the mobile station is typically equipped with only one receive antenna. Therefore, the downlink receiver design is a very challenging task. Different concepts for channel estimation, user separation, and equalization at the receiver of an OSC downlink transmission are introduced in this paper. Furthermore, the system capacity must be improved by suitable downlink power and resource allocation algorithms. Making realistic assumptions on the information available at the base station, an algorithm for joint power and radio resource allocation is proposed. Simulation results show the excellent performance of the proposed channel estimation algorithms, equalization schemes, and joint radio resource and power allocation algorithms in realistic VAMOS environments.
Empirical Effective Dimension and Optimal Rates for Regularized Least Squares Algorithm

Abstract : This paper presents an approach to model selection for regularized least-squares on reproducing kernel Hilbert spaces in the semi-supervised setting. The role of effective dimension was recently shown to be crucial in the definition of a rule for the choice of the regularization parameter, attaining asymptotic optimal performances in a minimax sense. The main goal of the present paper is showing how the effective dimension can be replaced by an empirical counterpart while conserving optimality. The empirical effective dimension can be computed from independent unlabelled samples. This makes the approach particularly appealing in the semi-supervised setting.
Biophysical studies of the c-MYC NHE III1 promoter: model quadruplex interactions with a cationic porphyrin.

Regulation of the structural equilibrium of G-quadruplex-forming sequences located in the promoter regions of oncogenes by the binding of small molecules has shown potential as a new avenue for cancer chemotherapy. In this study, microcalorimetry (isothermal titration calorimetry and differential scanning calorimetry), electronic spectroscopy (ultraviolet-visible and circular dichroism), and molecular modeling were used to probe the complex interactions between a cationic porphryin mesotetra (N-methyl-4-pyridyl) porphine (TMPyP4) and the c-MYC PU 27-mer quadruplex. The stoichiometry at saturation is 4:1 mol of TMPyP4/c-MYC PU 27-mer G-quadruplex as determined by isothermal titration calorimetry, circular dichroism, and ultraviolet-visible spectroscopy. The four independent TMPyP4 binding sites fall into one of two modes. The two binding modes are different with respect to affinity, enthalpy change, and entropy change for formation of the 1:1 and 2:1, or 3:1 and 4:1 complexes. Binding of TMPyP4, at or near physiologic ionic strength ([K(+)] = 0.13 M), is described by a "two-independent-sites model. " The two highest-affinity sites exhibit a K(1) of 1.6 x 10(7) M(-1) and the two lowest-affinity sites exhibit a K(2) of 4.2 x 10(5) M(-1). Dissection of the free-energy change into the enthalpy- and entropy-change contributions for the two modes is consistent with both "intercalative" and "exterior" binding mechanisms. An additional complexity is that there may be as many as six possible conformational quadruplex isomers based on the sequence. Differential scanning calorimetry experiments demonstrated two distinct melting events (T(m)1 = 74.7 degrees C and T(m)2 = 91.2 degrees C) resulting from a mixture of at least two conformers for the c-MYC PU 27-mer in solution.
Opioid Conversions in Acute Care

Objective: To discuss the historical basis and limitations of opioid conversion tables, review the relevant literature, and establish an evidence-based equianalgesic dose ratio (EDR) table for performing conversions in the acute care setting. Data Sources: Articles were identified through searches of MEDLINE (1966–January 2007) using the key words opioid, tolerance, conversion, dose, equianalgesic, equipotent, acute care, morphine, hydromorphone, fentanyl, methadone, and oxycodone. Additional references were located through a review of the bibliographies of articles cited and references cited in conversion tables. Study Selection and Data Extraction: All data sources identified were evaluated, and all information deemed relevant was included, with the exception of case series and case reports when higher level evidence was available. Data Synthesis: Opioid conversion tables are published in major textbooks, medical references, national guidelines, and review articles. Some conversion tables do not accurately reflect the dose ratios for which evidence is available. There is marginal evidence-based clinical data to support the dose ratios cited in these tables, particularly in the acute care setting where the clinical status of patients often changes rapidly. The barriers when performing route and opioid-to-opioid conversions in the acute care setting are formidable, but EDRs are provided, based on the best available evidence. Conclusions: In the acute care setting, calculation of dose ratios for opioids, based solely on opioid conversion tables, is an oversimplification of pain management, with a potential for adverse consequences. The calculation of EDRs is one step in an interdisciplinary process that must take into account patient- and institution-specific factors.
RegionKNN: A Scalable Hybrid Collaborative Filtering Algorithm for Personalized Web Service Recommendation

Several approaches to web service selection and recommendation via collaborative filtering have been studied, but seldom have these studies considered the difference between web service recommendation and product recommendation used in e-commerce sites. In this paper, we present RegionKNN, a novel hybrid collaborative filtering algorithm that is designed for large scale web service recommendation. Different from other approaches, this method employs the characteristics of QoS by building an efficient region model. Based on this model, web service recommendations will be generated quickly by using modified memory-based collaborative filtering algorithm. Experimental results demonstrate that apart from being highly scalable, RegionKNN provides considerable improvement on the recommendation accuracy by comparing with other well-known collaborative filtering algorithms.
Anemia and intestinal parasite infection in school children in rural Vietnam.

OBJECTIVES This study hypothesized that besides iron deficiency, intestinal parasites infection is also a determinant of anemia in schoolchildren in rural Vietnam. METHODS 400 primary schoolchildren from 20 primary schools in Tam Nong district, a poor rural area in Vietnam, were randomly selected from enrollment lists. Venous blood (5ml) was collected in a cross sectional study and analyzed for hemoglobin (Hb), serum ferritin (SF), serum transferrin receptor (TfR), serum C-reactive protein (CRP) and total immunoglobulin E (IgE). Stools samples were examined for hookworm, Trichuris, and Ascaris infection. Logistic regression was used to assess the effect of intestinal parasites on anemia. RESULTS The prevalence of anemia (Hb < 115g/l) was 25%. Iron deficiency (TfR > 8.5mg/L) occurred in 2% of the children. The prevalence of intestinal parasites was 92% with the highest prevalence for Trichuris (76%) and Ascaris (71%). More than 30% and 80% of the children showed an elevated CRP (> or = 8 mg/L) and IgE (> 90 IU/ml) concentration. Anemia status was borderline significantly associated with SF and not associated with TfR and CRP. The prevalence odds ratio for Trichuris infection was 1.96 (95% CI 1.07-3.59) and 2.00 (95% CI 1.08-3.65) with iron deficiency reflected by TfR and SF, respectively. CONCLUSION Anemia is highly prevalent among schoolchildren in Vietnam but may not be associated with iron deficiency. Trichuris infection is associated with a doubled risk of anemia, not mediated through iron deficiency. Chronic infection may play a role in anemia, but needs further investigation.
Brain Activation During Response Interference in Twins Discordant or Concordant for Obsessive Compulsive Symptoms

One of the core behavioral features associated with obsessive compulsive symptomatology is the inability to inhibit thoughts and/or behaviors. Neuroimaging studies have indicated abnormalities in frontostriatal and dorsolateral prefrontal – anterior cingulate circuits during inhibitory control in patients with obsessive compulsive disorder compared with controls. In the present study, task performance and brain activation during Stroop color-word and Flanker interference were compared within monozygotic twin pairs discordant for obsessive compulsive symptoms and between groups of pairs scoring very low or very high on obsessive compulsive symptoms, in order to examine the differential impact of non-shared environmental versus genetic risk factors for obsessive compulsive symptomatology on inhibitory control related functional brain activation. Although performance was intact, brain activation during inhibition of distracting information differed between obsessive compulsive symptom high-scoring compared to low-scoring subjects. Regions affected in the discordant group (e.g., temporal and anterior cingulate gyrus) were partly different from those observed to be affected in the concordant groups (e.g., parietal gyrus and thalamus). A robust increase in dorsolateral prefrontal activity during response interference was observed in both the high-scoring twins of the discordant sample and the high-scoring twins of the concordant sample, marking this structure as a possible key region for disturbances in inhibitory control in obsessive compulsive disorder.