Miracle-dz/UniFAR-FTUs huggingface dataset:
A life lived: experiencing an acquired facial ‘disfigurement’ and identity shift

With the advent of facial transplantation some academic authors have suggested that faces are significant for humans and that identities are located corporeally within faces and therefore transplantable. However, there has been little evidence to support these claims, particularly from a qualitative, theoretically informed social science background. Responding to this hiatus, in this thesis I set two interconnected research objectives: • to examine socio-cultural values associated with human faces in predominantly Western societies using secondary sources; • to explore the relationship between acquired facial ‘disfigurement’ and embodied identity shift using a narrative methodology. The first objective was addressed in full through an analytical review of largely Western secondary sources. It has become clear that faces, as part of bodies, are imbued with a variety of socio-cultural meanings on multiple levels. Individually people experience the world through their body and their face, making it a significant site for perception and sense making. On a societal level, faces and facial appearance have been associated with social reproduction (Giddens, 1991). For example, inaccurate and harmful historical associations between facial appearance and moral character still pervade British society. And, utilising the concept of faciality (Deleuze and Guattari, 1987, p.168) Twine (2002), Dudley (2002) and Benson (2008) have illustrated that the faces of people in sub-sections of society, generally those with very little power, can be conceptualised negatively and used to serve the interests of powerful elites. In terms of the second objective, most facial ‘disfigurement’ research has been completed using quantitative methods, resulting in partial knowledge and the disconnection of persons. Through the use of a phenomenological epistemology, embodiment position and a narrative methodology I have put the experiences of the 13 participants at the heart of the research. The analysis chapters focus on the participants’ embodied identities before, during and after an acquired facial ‘disfigurement’. In terms of conclusions, I have found that faces are important however, identities are not located within them but created and reshaped through embodied life experiences. I have also found that the relationship between embodied identity shift and acquired facial ‘disfigurement’ is one of contested negotiation between wider socio-cultural facial values, transitional/liminal identity states during and after the event(s) and the aim of previous identity restoration.
Proportions of Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus in Patients with Surgical Site Infections in Mainland China: A Systematic Review and Meta-Analysis

Background Sufficient details have not been specified for the epidemiological characteristics of Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA) among surgical site infections (SSIs) in mainland China. This systematic review aimed to estimate proportions of S. aureus and MRSA in SSIs through available published studies. Methods PubMed, Embase and four Chinese electronic databases were searched to identify relevant primary studies published between 2007 and 2012. Meta-analysis was conducted on the basis of logit-transformed metric for proportions of S. aureus and MRSA, followed by pre-defined subgroup meta-analysis. Random-effects meta-regression was also conducted to explore the impact of possible factors on S. aureus proportions. Results 106 studies were included, of which 38 studies involved MRSA. S. aureus accounted for 19.1% (95%CI 17.2-21.0%; I2 = 84.1%) of all isolates in SSIs, which was roughly parallel to 18.5% in the United States (US) (P-value = 0.57) but significantly exceeded those calculated through the surveillance system in China (P-value<0.001). In subgroup analysis, S. aureus in patients with thoracic surgery (41.1%, 95%CI 26.3-57.7%; I2 = 74.4%) was more common than in those with gynecologic surgery (20.1%, 95%CI 15.6-25.6%; I2 = 33.0%) or abdominal surgery (13.8%, 95%CI 10.3-18.4%; I2 = 70.0%). Similar results were found in meta-regression. MRSA accounted for 41.3% (95%CI 36.5-46.3%; I2 = 64.6%) of S. aureus, significantly lower than that in the US (P-value = 0.001). MRSA was sensitive to vancomycin (522/522) and linezolid (93/94), while 79.9% (95%CI 67.4-88.4%; I2 = 0%) and 92.0% (95%CI 80.2-97.0%; I2 = 0%) of MRSA was resistant to clindamycin and erythromycin respectively. Conclusion The overall proportion of S. aureus among SSIs in China was similar to that in the US but seemed higher than those reported through the Chinese national surveillance system. Proportions of S. aureus SSIs may vary with different surgery types. Commonly seen in SSIs, MRSA tended to be highly sensitive to vancomycin and linezolid but mostly resistant to clindamycin and erythromycin.
Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease.

BACKGROUND & AIMS Histologic analysis of liver biopsy specimens allows for grading and staging of nonalcoholic fatty liver disease (NAFLD). We performed a longitudinal study to investigate the long-term prognostic relevance of histologic features for patients with NAFLD. METHODS We performed a retrospective analysis of 619 patients diagnosed with NAFLD from 1975 through 2005 at medical centers in the United States, Europe, and Thailand. Patients underwent laboratory and biopsy analyses, and were examined every 3-12 months after their diagnosis. Outcomes analyzed were overall mortality, liver transplantation, and liver-related events. Cumulative outcomes were compared by log-rank analysis. Cox proportional-hazards regression was used to estimate adjusted hazard ratios (HRs). Time at risk was determined from the date of liver biopsy to the date of outcome or last follow-up examination. RESULTS Over a median follow-up period of 12.6 years (range, 0.3-35.1 y), 193 of the patients (33.2%) died or underwent liver transplantation. Features of liver biopsies significantly associated with death or liver transplantation included fibrosis stage 1 (HR, 1.88; 95% confidence interval [CI], 1.28-2.77), stage 2 (HR, 2.89; 95% CI, 1.93-4.33), stage 3 (HR, 3.76; 95% CI, 2.40-5.89), and stage 4 (HR, 10.9; 95% CI, 6.06-19.62) compared with stage 0, as well as age (HR, 1.07; 95% CI, 1.05-1.08), diabetes (HR, 1.61; 95% CI, 1.13-2.30), current smoking (HR, 2.62; 95% CI, 1.67-4.10), and statin use (HR, 0.32; 95% CI, 0.14-0.70). Twenty-six patients (4.2%) developed liver-related events; fibrosis stage 3 (HR, 14.2; 95% CI, 3.38-59.68) and stage 4 (HR, 51.5; 95% CI, 9.87-269.2) compared with stage 0, were associated significantly with the events. Patients with fibrosis, regardless of steatohepatitis or NAFLD activity score, had shorter survival times than patients without fibrosis. CONCLUSIONS In a longitudinal study of patients with NAFLD, fibrosis stage, but no other histologic features of steatohepatitis, were associated independently with long-term overall mortality, liver transplantation, and liver-related events.
Comparison of ribotyping and pulsed-field gel electrophoresis for molecular typing of Acinetobacter isolates

Seventy-three isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex, including 26 isolates from 10 hospital outbreaks, were typed by ribotyping with EcoRI and ClaI and by pulsed-field gel electrophoresis (PFGE) of genomic DNA after digestion with ApaI. Ribotyping with EcoRI distinguished 31 ribopatterns. Digestion with ClaI generated another eight ribotypes. PFGE, in contrast, identified 49 distinct patterns with seven variants. Both methods detected all outbreak-related isolates. By ribotyping, nine epidemiologically unrelated strains could not be differentiated from outbreak strains, in contrast to only one isolate not identified by PFGE. Thus, PFGE was more discriminating than ribotyping. However, ribotyping is known to generate banding patterns specific to each DNA group in the A. calcoaceticus-A. baumannii complex that may be used for taxonomic identification of the strains. PFGE was shown to lack this property. Both methods are therefore useful for strain differentiation in epidemiological studies of Acinetobacter isolates.
Search for best practices in inclusive recreation: Programmatic findings

There has been exponential growth in the number of recreation agencies adopting inclusive service delivery (ISD) practices. While many of these agencies are experiencing success with these initiatives, many others are not. The data reported here were collected as part of a comprehensive, qualitative study designed to identify best practices being employed by recreation agencies perceived as successful with ISD by leaders in the field at administrative, programmatic, and consumer levels. Results note that successful agencies are using best practices described in the literature; however, they are implementing these practices in highly individualized manners based on the needs and characteristics of the agency and community. Participant assessment, accommodation plans, behavioral interventions, adaptations, inclusion support staff, personal care, on-site technical support for general recreation staff, preparing nondisabled peers, facilitating peer interaction, and documentation and program evaluation strategies are explored with detailed accounts of variations in implementation strategies.
Engaging countries : strengthening compliance with international environmental accords

A framework for analysis, Harold K. Jacobson and Edith Brown Weiss how compliance happens and doesn't happen domestically, David Vogel and Timothy Kessler managing compliance - a comparative perspective, Abram Chayes et al contingent knowledge - implications for implementation and compliance, Sheila Jasanoff the five international treaties - a living history, Edith Brown Weiss the United States - taking environmental treaties seriously, Michael J. Glennon and Alison L. Stewart the European Union and compliance - a story in the making, Alberta M. Sbragia and Philipp M. Hildebrand Japan - consensus-based compliance, James V. Feinerman and Koichiro Fujikura.
Robust Approximate Inverse Preconditioning for the Conjugate Gradient Method

We present a variant of the AINV factorized sparse approximate inverse algorithm which is applicable to any symmetric positive definite matrix. The new preconditioner is breakdown-free and, when used in conjunction with the conjugate gradient method, results in a reliable solver for highly ill-conditioned linear systems. We also investigate an alternative approach to a stable approximate inverse algorithm, based on the idea of diagonally compensated reduction of matrix entries. The results of numerical tests on challenging linear systems arising from finite element modeling of elasticity and diffusion problems are presented.
Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation

Meningococcal secreted proteins (MSPs) have been poorly characterized. We hypothesized that MSPs play essential roles in host–bacterial interactions and in the pathogenesis of disease. In order to test this, we examined differential host gene expression in human meningeal‐derived cells, in response to endotoxin‐depleted MSPs compared to live bacteria. Using expression arrays, upregulated expression of several pro‐inflammatory and apoptosis‐related genes was found to be induced by MSPs. The transcription and translation of representative genes was confirmed by using various methods. Increased interleukin 8 (IL‐8) and cyclooxygenase 2 (COX‐2) gene transcription was confirmed using real‐time PCR. Upregulated IL‐8, IL‐6, ICAM‐1 and COX‐2 protein expression were confirmed by ELISA, flow cytometry or Western immunoblots. Furthermore, exposure of cells to MSPs or live meningococci induced a small significant resistance effect to staurosporine‐induced apoptosis. Secreted meningococcal virulence factors are therefore important in inducing host inflammatory responses and resistance to apoptosis, and they are worthy of extensive investigation.
General and specific abilities to recognise negative emotions, especially disgust, as portrayed in the face and the body

We examined the ability of 150–166 undergraduate students to assign four negative emotions (sadness, fear, disgust, and anger) to five sets of emotion expression stimuli: a standard of face photographs expressing basic emotions, faces that were morphs of standards for these emotions, a special set of faces that was designed to detect different components of disgust expressions, and two sets of dynamic, video clips displays of emotions as described in traditional Hindu scriptures and used in classical Hindu dance. One of these sets presented the full body traditional displays (including hands and face), while in the second set, the same clips were used but the facial expressions were blocked out. Participants also completed an obsessive compulsive inventory and the disgust scale. Major findings are that: (a) there are some substantial individual differences in ability to correctly identify emotions; (b) the ability to detect facial emotions correlates substantially (.49) with ability to detect bodily emotions; (c) there is no evidence for specific deficits in the detection of any particular emotion; and (d) there is no relation between individual differences in obsessive‐compulsive disorder (OCD) tendencies or disgust sensitivity, in a normal sample and the ability to detect disgust.
Redistribution of coronary microvascular resistance produced by dipyridamole.

This study assessed the redistribution of coronary microvascular resistance during vasodilation produced by dipyridamole. Measurements of microvascular diameter and pressure in the beating left ventricle of anesthetized cats were accomplished by means of a computer-controlled system that enabled measurements in the beating heart. Resistances of coronary arteries, microvessels, and veins were calculated from the quotients of the pressure gradient across each vascular compartment and myocardial perfusion (radioactive microspheres). Administration of dipyridamole increased coronary blood flow from 1.80 +/- 0.09 to 6.42 +/- 0.31 ml.min-1. g-1 (P less than 0.05). During control conditions, 25 +/- 8% of total resistance occurred in coronary arteries (proximal to 170 microns), 68 +/- 8% of total resistance was in coronary microvessels (between arterioles less than 170 microns in diameter and venules less than 150 microns in diameter), and 7 +/- 7% of resistance resided in veins (distal to 150 microns). There was a significant redistribution (P less than 0.05) of resistance in all vessel classes after dipyridamole: coronary arteries constituted 42 +/- 6%, microvessels contained 27 +/- 5%, and veins had 31 +/- 8% of total coronary resistance. During control conditions, vascular resistance in coronary arteries and microvessels was 17 +/- 4 and 45 +/- 6 mmHg.min.g.ml-1, respectively. During vasodilation, resistance was significantly reduced (P less than 0.05) in both the arterial and microvessel segments to 6 +/- 2 and 4 +/- 2 mmHg.min.g.ml-1, respectively. Venous resistance was not significantly affected during dipyridamole-induced vasodilation. In conclusion, there was a marked reduction of coronary vascular resistance in response to dipyridamole, with the major component accounted for by dilation of microvessels. (ABSTRACT TRUNCATED AT 250 WORDS)
A p70 killer cell inhibitory receptor specific for several HLA-B allotypes discriminates among peptides bound to HLA-B*2705

Natural killer (NK) cells express a repertoire of killer cell inhibitory receptors (KIR) for major histocompatibility complex (MHC) class I molecules. KIR specificity for MHC class I can be broad, as in the case of a single p70 KIR that can recognize several HLA-B allotypes, including HLA-B*2705. On the other hand, recognition of MHC class I can also be highly specific, as in the case of NK clones that recognize HLA-B*2705 in a peptide-specific manner. Most NK cells express multiple KIR sequences. To determine whether the broad and specific types of HLA-B recognition by NK cells reflect the use of different receptors or a property of a single KIR we analyzed the recognition of HLA-B*2705 by the p70 KIR-11, known to recognize several HLA-B allotypes. Vaccinia virus-mediated expression of KIR-11 in NK clones resulted in inhibition by HLA-B*2705 molecules on wild type but not on target cells deficient in the transporter for antigen presentation (TAP). Two peptides (FRYNGLIHR and RRSKEITVR) loaded onto HLA-B*2705 molecules on TAP-deficient cells provided protection from lysis by NK cells expressing KIR-11 but three other B27-specific peptides did not. As the five peptides bound to HLA-B*2705 with similar stability, these data demonstrate that a single KIR specific for several HLA-B allotypes recognizes a subset of peptides bound to HLA- B*2705.
Tradition oder Zukunft? 50 Jahre Deutsche Gesellschaft für Erziehungswissenschaft aus bildungshistorischer Sicht

Der nachfolgende Beitrag interpretiert die in jungster Zeit vollzogenen Sezessionsbewegungen innerhalb der DGfE als Ausdruck eines grundsatzlichen Problems, das bereits in der Grundungszeit der Gesellschaft (1964) virulent war und schon damals eine Vorgeschichte hatte. Die ubergeordnete These lautet, dass die leitende Ideologie der damaligen DGfE einem Zukunftsverstandnis verpflichtet war, das sich masgeblich aus der idealistischen Tradition nahrte. Dadurch grenzte sie vorwiegend auseruniversitare Akteure der Bildungsreform aus, die sich einem hauptsachlich in den USA entwickelten, expertokratischen Zukunftskonzept verschrieben hatten und sich dabei auf spezifische Psychologiemodelle stutzten. Als nach dem Ende des Kalten Krieges die OECD ihre Vision von Schulpolitik und -reform durchsetzen konnte, gelang es dieser vermeintlich traditionsfreien Ideologie padagogischer Planung, sich auch innerhalb der DGfE zu etablieren. Dies erzeugte allerdings eine eklatante Polaritat mit der traditionellen Vorstellung von Bildung - ein Spannungsfeld, das sich nur durch historisch-komparative Analysen konstruktiv losen lasst. (DIPF/Orig.) The author interprets the most recent secessionist movements within the GERA as the manifestation of a fundamental problem that had already been virulent at the time of the association's foundation (1964) and that had not been utterly new, even then. The primary thesis states that the guiding ideology of the GERA at that time was bound to a concept of future primarily nourished by the idealist tradition. Thus, the association ostracized mainly extramural actors of educational reform who were committed to an expertocratic concept of the future, developed mainly in the United States, and who, in this, relied on specific psychology models. When, after the end of the Cold War, the OECD was able to enforce its vision of school policy and educational reform, this ideology of pedagogical planning, supposedly unimpeded by any traditions, managed to establish itself within the GERA, too. This, however, created a blatant polarity with the traditional concept of education - a field of tension that can only be dissolved constructively through historical-comparative analyses. (DIPF/Orig.)
Genes regulated by learning in the hippocampus

The enduring changes in long‐term memory probably depend on regulation of gene expression in the hippocampus. To seek genes regulated by learning, we used microarray technology to compare hippocampal gene expression in mice undergoing training in the Morris water maze and control mice forced to swim for the same period in the absence of a hidden platform. ANOVA was employed to prioritize genes for further study, and three genes were confirmed by real‐time PCR as being regulated during learning. One of the genes was the α subunit of the platelet‐derived growth factor receptor (Pdgfra); another showed homology to DnaJ and cAMP response element‐binding protein 2 (CREB2); and a third was novel. These genes may provide useful insights into the molecular mechanisms of hippocampal learning. © 2003 Wiley‐Liss, Inc.
Endoscopic Treatment of Subglottic and Tracheal Stenosis by Radial Laser Incision and Dilation

Five patients with severe fibrous subglottic and tracheal stenosis were treated by endoscopic radial laser incision and dilation using both carbon dioxide and neodymium:yttrium aluminum garnet lasers. Good results were noted without complications in all patients in a follow-up period of at least 1 year. Careful selection of patients, excluding those with tracheal collapse or tracheomalacia, and preservation of tracheal epithelium with minimal heat and mechanical trauma are considered essential for good results.
The West Nile Virus Capsid Protein Blocks Apoptosis through a Phosphatidylinositol 3-Kinase-Dependent Mechanism

ABSTRACT West Nile virus (WNV) is a mosquito-transmitted pathogen that can cause serious disease in humans. Our laboratories are focused on understanding how interactions between WNV proteins and host cells contribute to virus replication and pathogenesis. WNV replication is relatively slow, and on the basis of earlier studies, the virus appears to activate survival pathways that delay host cell death during virus replication. The WNV capsid is the first viral protein produced in infected cells; however, its role in virus assembly is not required until after replication of the genomic RNA. Accordingly, from a temporal perspective, it is perfectly suited to block host cell apoptosis during virus replication. In the present study, we provide evidence that the WNV capsid protein blocks apoptosis through a phosphatidylinositol (PI) 3-kinase-dependent pathway. Specifically, expression of this protein in the absence of other viral proteins increases the levels of phosphorylated Akt, a prosurvival kinase that blocks apoptosis through multiple mechanisms. Treatment of cells with the PI 3-kinase inhibitor LY294002 abrogates the protective effects of the WNV capsid protein.
Drug Repositioning for Diabetes Based on 'Omics' Data Mining

Drug repositioning has shorter developmental time, lower cost and less safety risk than traditional drug development process. The current study aims to repurpose marketed drugs and clinical candidates for new indications in diabetes treatment by mining clinical ‘omics’ data. We analyzed data from genome wide association studies (GWAS), proteomics and metabolomics studies and revealed a total of 992 proteins as potential anti-diabetic targets in human. Information on the drugs that target these 992 proteins was retrieved from the Therapeutic Target Database (TTD) and 108 of these proteins are drug targets with drug projects information. Research and preclinical drug targets were excluded and 35 of the 108 proteins were selected as druggable proteins. Among them, five proteins were known targets for treating diabetes. Based on the pathogenesis knowledge gathered from the OMIM and PubMed databases, 12 protein targets of 58 drugs were found to have a new indication for treating diabetes. CMap (connectivity map) was used to compare the gene expression patterns of cells treated by these 58 drugs and that of cells treated by known anti-diabetic drugs or diabetes risk causing compounds. As a result, 9 drugs were found to have the potential to treat diabetes. Among the 9 drugs, 4 drugs (diflunisal, nabumetone, niflumic acid and valdecoxib) targeting COX2 (prostaglandin G/H synthase 2) were repurposed for treating type 1 diabetes, and 2 drugs (phenoxybenzamine and idazoxan) targeting ADRA2A (Alpha-2A adrenergic receptor) had a new indication for treating type 2 diabetes. These findings indicated that ‘omics’ data mining based drug repositioning is a potentially powerful tool to discover novel anti-diabetic indications from marketed drugs and clinical candidates. Furthermore, the results of our study could be related to other disorders, such as Alzheimer’s disease.