Miracle-dz/UniFAR-FTUs huggingface dataset:
Nitrogen Fuelling of the Pelagic Food Web of the Tropical Atlantic

We estimated the relative contribution of atmosphere (ic Nitrogen (N) input (wet and dry deposition and N fixation) to the epipelagic food web by measuring N isotopes of different functional groups of epipelagic zooplankton along 23°W (17°N-4°S) and 18°N (20-24°W) in the Eastern Tropical Atlantic. Results were related to water column observations of nutrient distribution and vertical diffusive flux as well as colony abundance of Trichodesmium obtained with an Underwater Vision Profiler (UVP5). The thickness and depth of the nitracline and phosphocline proved to be significant predictors of zooplankton stable N isotope values. Atmospheric N input was highest (61% of total N) in the strongly stratified and oligotrophic region between 3 and 7°N, which featured very high depth-integrated Trichodesmium abundance (up to 9.4×104 colonies m-2), strong thermohaline stratification and low zooplankton δ15N (~2‰). Relative atmospheric N input was lowest south of the equatorial upwelling between 3 and 5°S (27%). Values in the Guinea Dome region and north of Cape Verde ranged between 45 and 50%, respectively. The microstructure-derived estimate of the vertical diffusive N flux in the equatorial region was about one order of magnitude higher than in any other area (approximately 8 mmol m-2 d 1). At the same time, this region received considerable atmospheric N input (35% of total). In general, zooplankton δ15N and Trichodesmium abundance were closely correlated, indicating that N fixation is the major source of atmospheric N input. Although Trichodesmium is not the only N fixing organism, its abundance can be used with high confidence to estimate the relative atmospheric N input in the tropical Atlantic (r2 = 0.95). Estimates of absolute N fixation rates are two- to tenfold higher than incubation-derived rates reported for the same regions. Our approach integrates over large spatial and temporal scales and also quantifies fixed N released as dissolved inorganic and organic N. In a global analysis, it may thus help to close the gap in oceanic N budgets.
Elevated red cell distribution width is associated with advanced fibrosis in NAFLD

Background/Aims The red-blood-cell distribution width (RDW) is a newly recognized risk marker in patients with cardiovascular disease, but its role in nonalcoholic fatty liver disease (NAFLD) has not been well defined. The aim of the present study was to determine the association between RDW values and the level of fibrosis in NAFLD according to BARD and FIB-4 scores. Methods This study included 24,547 subjects who had been diagnosed with NAFLD based on abdominal ultrasonography and questionnaires about alcohol consumption. The degree of liver fibrosis was determined according to BARD and FIB-4 scores. The association between RDW values and the degree of fibrosis in NAFLD was analyzed retrospectively. Results After adjusting for age, hemoglobin level, mean corpuscular volume, history of hypertension, history of diabetes, and high-sensitivity C-reactive protein, the RDW values were 12.61±0.41% (mean±SD), 12.70±0.70%, 12.77±0.62%, 12.87±0.82%, and 13.25±0.90% for those with BARD scores of 0, 1, 2, 3, and 4, respectively, and 12.71±0.72%, 12.79±0.66%, and 13.23±1.52% for those with FIB-4 scores of <1.30, 1.31-2.66, and ≥2.67, respectively (P<0.05). The prevalence of advanced fibrosis (BARD score of 24 and FIB-4 score of ≥1.3) increased with the RDW [BARD score: 51.1% in quartile 1 (Q1) vs. 63.6% in Q4; FIB-4 score: 6.9% in Q1 vs. 10.5% in Q4; P<0.001]. After adjustments, the odds ratio of having advanced fibrosis for those in Q4 compared to Q1 were 1.76 (95%CI=1.55-2.00, P<0.001) relative to BARD score and 1.69 (95%CI=1.52-1.98, P<0.001) relative to FIB-4 score. Conclusions Elevated RDW is independently associated with advanced fibrosis in NAFLD.
A systematic description of shocks in gamma-ray bursts – I. Formulation

Since the suggestion of relativistic shocks as the origin of gamma-ray bursts (GRBs) in the early 1990s, the mathematical formulation of this process has stayed at a phenomenological level. One of the reasons for the slow development of theoretical works has been the simple power-law behaviour of the afterglows hours or days after the prompt gamma-ray emission. It was believed that they could be explained with these formulations. Nowadays, with the launch of the Swift satellite and implementation of robotic ground follow-ups, GRBs and their afterglow can be observed at multi-wavelengths from a few tens of seconds after trigger onwards. These observations have led to the discovery of features unexplainable by the simple formulation of the shocks and emission processes used up to now. Some of these features can be inherent in the nature and activities of the GRBs' central engines which are not yet well understood. On the other hand, the devil is in the detail and others may be explained with a more detailed formulation of these phenomena and without ad hoc addition of new processes. Such a formulation is the goal of this work. We present a consistent formulation of the kinematics and dynamics of the collision between two spherical relativistic shells, their energy dissipation and their coalescence. It can be applied to both internal and external shocks. Notably, we propose two phenomenological models for the evolution of the emitting region during the collision. One of these models is more suitable for the prompt/internal shocks and late external shocks, and the other for the afterglow/external collisions as well as the onset of internal shocks. We calculate a number of observables such as flux, lag between energy bands and hardness ratios. One of our aims has been a formulation complex enough to include the essential processes, but simple enough such that the data can be directly compared with the theory to extract the value and evolution of physical quantities. To accomplish this goal, we also suggest a procedure for extracting parameters of the model from data. In a companion paper, we numerically calculate the evolution of some simulated models and compare their features with the properties of the observed GRBs.
Investigating the antecedents of cyberbullying

This research attempted to fill the knowledge gap in cyberbullying by revealing one of the five main themes of cyberbullying that is the antecedents that contribute to the working hypothesis or paradigm model of the phenomenon. The actual research reveals the antecedents and the contexts and prevailing conditions that influence it, as well as the phenomenon, the coping strategies and the consequences resulting from the coping strategies. Using a grounded theory methodology, in-depth interviews were conducted on adolescents aged between 12 to 18 years from different schools in the state of Perlis. The data were analyzed using NVivo 10 by methodically coding and categorizing the data in open, axial and selective coding to arrive at a model development. A paradigm model was obtained based on these themes and subthemes which uniquely contribute to the body of knowledge on cyberbullying phenomenon in Malaysia. The involved elements derived from the model are; the antecedents of cyberbullying; the phenomenon; the coping strategies by informants and the consequences resulting from these strategies. The significance of this study lies in its attempt to provide a working framework for reducing adolescents’ technology abuse that will eventually lead to cyberbullying and to find solutions for adolescents to tackle cyberbullying problems if it ever happened. This study is hoped to benefit all the parties: adolescents, parents, teachers, and other stakeholders to minimize adolescents’ cyberbullying phenomenon.
Sensitivity of Bovine Tuberculosis Surveillance in Wildlife in France: A Scenario Tree Approach

Bovine tuberculosis (bTB) is a common disease in cattle and wildlife, with an impact on animal and human health, and economic implications. Infected wild animals have been detected in some European countries, and bTB reservoirs in wildlife have been identified, potentially hindering the eradication of bTB from cattle populations. However, the surveillance of bTB in wildlife involves several practical difficulties and is not currently covered by EU legislation. We report here the first assessment of the sensitivity of the bTB surveillance system for free-ranging wildlife launched in France in 2011 (the Sylvatub system), based on scenario tree modelling. Three surveillance system components were identified: (i) passive scanning surveillance for hunted wild boar, red deer and roe deer, based on carcass examination, (ii) passive surveillance on animals found dead, moribund or with abnormal behaviour, for wild boar, red deer, roe deer and badger and (iii) active surveillance for wild boar and badger. The application of these three surveillance system components depends on the geographic risk of bTB infection in wildlife, which in turn depends on the prevalence of bTB in cattle. We estimated the effectiveness of the three components of the Sylvatub surveillance system quantitatively, for each species separately. Active surveillance and passive scanning surveillance by carcass examination were the approaches most likely to detect at least one infected animal in a population with a given design prevalence, regardless of the local risk level and species considered. The awareness of hunters, which depends on their training and the geographic risk, was found to affect surveillance sensitivity. The results obtained are relevant for hunters and veterinary authorities wishing to determine the actual efficacy of wildlife bTB surveillance as a function of geographic area and species, and could provide support for decision-making processes concerning the enhancement of surveillance strategies.
Organizational Responses to Institutional Pressures: Reconfiguration of Spaces in Nanosciences and Nanotechnologies

The literature on organizational responses to institutional pressures describes responses ranging from compliance to resistance via different modes of decoupling. However, although these studies provide a greater understanding of the phenomenon, they tend to consider the different elements separately. Through a comparative case study of six research teams in the area of nanosciences and nanotechnologies, we offer three contributions. Our first contribution is to the decoupling literature by way of a complementary and cohesive framework, which shows that organizations vary in their responses by reconfiguring their physical (policy and materiality), mental (meaning) and social (identity) spaces, and that each space can be reconfigured at the core or periphery, or not be reconfigured. Our second and third contributions are through descriptions of two modes of organizational responses to institutional pressures and two factors explaining the variety of responses.
Foundations of Representation: Where Might Graphical Symbol Systems Come From?

It has been suggested that iconic graphical signs evolve into symbolic graphical signs through repeated usage. This article reports a series of interactive graphical communication experiments using a 'pictionary' task to establish the conditions under which the evolution might occur. Experiment 1 rules out a simple repetition based account in favor of an account that requires feedback and interaction between communicators. Experiment 2 shows how the degree of interaction affects the evolution of signs according to a process of grounding. Experiment 3 confirms the prediction that those not involved directly in the interaction have trouble interpreting the graphical signs produced in Experiment 1. On the basis of these results, this article argues that icons evolve into symbols as a consequence of the systematic shift in the locus of information from the sign to the users' memory of the sign's usage supported by an interactive grounding process.
Pharmacokinetics of sunitinib in an obese patient with a GIST.

Sunitinib is a potent inhibitor of a variety of receptor tyrosine kinases including vascular endothelial growth factor receptors (1, 2 and 3), fetal liver tyrosine kinase receptor 3, stem-cell factor receptor (KIT), platelet-derived growth factor receptors (alpha and beta) and colony-stimulating factor-1 receptor. It is approved for the treatment of imatinib-resistant gastrointestinal stromal tumours (GISTs) and metastatic renal cell cancer. Data about the pharmacokinetics of sunitinib in seriously obese patients are lacking. We here report the pharmacokinetic data of such an obese GIST patient treated with sunitinib.
Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation

Bone morphogenetic protein 4 (BMP4) is crucial for the formation of FLK1-expressing (FLK1+) mesodermal cells. To further define the requirement for BMP signaling in the differentiation of blood, endothelial and smooth muscle cells from FLK1+ mesoderm, we inactivated Alk3 (Bmpr1a) in FLK1+ cells by crossing Alk3floxed/floxed and Flk1+/CreAlk3+/floxed mice. Alk3 conditional knockout (CKO) mice died between E10.5 and E11.5. Unexpectedly, Alk3 CKO embryos did not show any hematopoietic defects. However, Alk3 CKO embryos displayed multiple abnormalities in vascular development, including vessel remodeling and maturation, which contributed to severe abdominal hemorrhage. Alk3 CKO embryos also displayed defects in atrioventricular canal (AVC) endocardial cushion formation in the heart. Collectively, our studies indicate a crucial role for ALK3 in vessel remodeling, vessel integrity and endocardial cushion formation during the development of the circulation system.
An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus

The unique anatomical and functional features of principal and interneuron populations are critical for the appropriate function of neuronal circuits. Cell type-specific properties are encoded by selective gene expression programs that shape molecular repertoires and synaptic protein complexes. However, the nature of such programs, particularly for post-transcriptional regulation at the level of alternative splicing is only beginning to emerge. We here demonstrate that transcripts encoding the synaptic adhesion molecules neurexin-1,2,3 are commonly expressed in principal cells and interneurons of the mouse hippocampus but undergo highly differential, cell type-specific alternative splicing. Principal cell-specific neurexin splice isoforms depend on the RNA-binding protein Slm2. By contrast, most parvalbumin-positive (PV+) interneurons lack Slm2, express a different neurexin splice isoform and co-express the corresponding splice isoform-specific neurexin ligand Cbln4. Conditional ablation of Nrxn alternative splice insertions selectively in PV+ cells results in elevated hippocampal network activity and impairment in a learning task. Thus, PV-cell-specific alternative splicing of neurexins is critical for neuronal circuit function DOI: http://dx.doi. org/10.7554/eLife.22757. 001
Flare magnetic reconnection and relativistic particles in the 2003 October 28 event

An X17.2 solar flare occurred on 2003 October 28, accompanied by multi-wavelength emissions and a high flux of relativistic particles observed at 1 AU. We present the analytic results of the TRACE, SOHO, RHESSI, ACE, GOES, hard X-ray (INTEGRAL satellite), radio (Ondeřejov radio telescope), and neutron monitor data. It is found that the inferred magnetic reconnection electric field correlates well with the hard X-ray, gamma-ray, and neutron emission at the Sun. Thus the flare's magnetic reconnection probably makes a crucial contribution to the prompt relativistic particles, which could be detected at 1 AU. Since the neutrons were emitted a few minutes before the injection of protons and electrons, we propose a magnetic-field evolution configuration to explain this delay. We do not exclude the effect of CME-driven shock, which probably plays an important role in the delayed gradual phase of solar energetic particles.
Time and message complexities of the generalized distributed mobility-adaptive clustering (GDMAC) algorithm in wireless multihop networks

Distributed mobility-adaptive clustering algorithms are used in multihop ad hoc networks to separate the nodes into logical groups and build up a hierarchical network architecture. This paper studies the convergence time and message complexity of Basagni's generalized DMAC clustering algorithm. Our results show how many time steps and signaling messages are typically needed after a single topology change to re-achieve a stable and valid cluster structure. Furthermore, we discuss chain reactions that can occur along a path if certain conditions are fulfilled. Finally, we regard a mobile scenario in order to analyze (a) the number of signaling messages per node and time step and (b) the percentage of time steps in which the cluster structure is invalid. Our results give a qualitative insight on the behavior of clustering in ad hoc networks. In particular, they show that tuning the density of clusterheads and employing a hysteresis parameter for cluster changes can significantly improve the performance.
Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems

Graphene quantum dots (GQDs) were rationally fabricated as a traceable drug delivery system for the targeted, pH-sensitive delivery of a chemotherapeutic drug into cancer cells. The GQDs served as fluorescent carriers for a well-known anticancer drug, doxorubicin (Dox). The whole system has the capacity for simultaneous tracking of the carrier and of drug release. Dox release is triggered upon acidification of the intracellular vesicles, where the carriers are located after their uptake by cancer cells. Further functionalization of the loaded carriers with targeting moieties such as arginine-glycine-aspartic acid (RGD) peptides enhanced their uptake by cancer cells. DU-145 and PC-3 human prostate cancer cell lines were used to evaluate the anticancer ability of Dox-loaded RGD-modified GQDs (Dox-RGD-GQDs). The results demonstrated the feasibility of using GQDs as traceable drug delivery systems with the ability for the pH-triggered delivery of drugs into target cells.
AT-EASE : A Tool for Early and Quick Usability Evaluation of Smartphone Application

We present our tool AT-EASE: A Tool for EArly and quick uSability Evaluation. The tool can help mobile app designers simulate their low-fidelity prototypes on real mobile devices. Designers are able to perform iterative design based on the usability data provided by AT-EASE. To enable a more realistic simulation regarding screen navigation, AT-EASE provides multiple ways to override the default behavior that just shows a screen to another. To provide meaningful usability evaluation to designers, we design a set of experimental metrics derived from the raw data collected by AT-EASE. We demonstrate the basic usage of AT-EASE, and present two experiments with four human subjects on two Android apps to show the effectiveness of ATEASE. The experiment results show some possible correlations between the usability problems observed on real apps and revealed during the AT-EASE study.
A Chromosome Segment Substitution Library of Weedy Rice for Genetic Dissection of Complex Agronomic and Domestication Traits

Chromosome segment substitution lines (CSSLs) are a powerful alternative for locating quantitative trait loci (QTL), analyzing gene interactions, and providing starting materials for map-based cloning projects. We report the development and characterization of a CSSL library of a U.S. weedy rice accession ‘PSRR-1’ with genome-wide coverage in an adapted rice cultivar ‘Bengal’ background. The majority of the CSSLs carried a single defined weedy rice segment with an average introgression segment of 2.8 % of the donor genome. QTL mapping results for several agronomic and domestication traits from the CSSL population were compared with those obtained from two recombinant inbred line (RIL) populations involving the same weedy rice accession. There was congruence of major effect QTLs between both types of populations, but new and additional QTLs were detected in the CSSL population. Although, three major effect QTLs for plant height were detected on chromosomes 1, 4, and 8 in the CSSL population, the latter two escaped detection in both RIL populations. Since this was observed for many traits, epistasis may play a major role for the phenotypic variation observed in weedy rice. High levels of shattering and seed dormancy in weedy rice might result from an accumulation of many small effect QTLs. Several CSSLs with desirable agronomic traits (e.g. longer panicles, longer grains, and higher seed weight) identified in this study could be useful for rice breeding. Since weedy rice is a reservoir of genes for many weedy and agronomic attributes, the CSSL library will serve as a valuable resource to discover latent genetic diversity for improving crop productivity and understanding the plant domestication process through cloning and characterization of the underlying genes.
Accounting for Wage and Employment Changes in the U.S. From 1968-2000: A Dynamic Model of Labor Market Equilibrium, Second Version

In this paper, we present a unified treatment of and explanation for the evolution of wages and employment in the U.S. over the last 30 years. Specifically, we account for the pattern of changes in wage inequality, for the increased relative wage and employment of women, for the emergence of the college wage premium and for the shift in employment from the goods to the service-producing sector. The underlying theory we adopt is neoclassical, a two-sector competitive labor market economy in which the supply of and demand for labor of heterogeneous skill determines spot market skill-rental prices. The empirical approach is structural. The model embeds many of the features that have been posited in the literature to have contributed to the changing U.S. wage and employment structure including skill-biased technical change, capital-skill complementarity, changes in relative product-market prices, changes in the productivity of labor in home production and demographics such as changing cohort size and fertility.
The correlation between the Trendelenburg position and the stroke volume variation

Background The stroke volume variation (SVV), based on lung-heart interaction during mechanical ventilation, is a useful dynamic parameter for fluid responsiveness. However, it is affected by many factors. The aim of this study was to evaluate the effects of SVV on Trendelenburg (T) and reverse Trendelenburg (RT) position and to further elaborate on the patterns of the SVV with position. Methods Forty-two patients undergoing elective surgery were enrolled in this study. Fifteen minutes after standardized induction of anesthesia with propofol, fentanyl, and rocuronium with volume controlled ventilation (tidal volume of 8 ml/kg of ideal body weight, inspiration : expiration ratio of 1 : 2, and respiratory rate of 10-13 breaths/min), the patients underwent posture changes as follows: supine, T position at slopes of operating table of -5°, -10°, and -15°, and RT position at slopes of operating table of 5°, 10°, and 15°. At each point, SVV, cardiac output (CO), peak airway pressure (PAP), mean blood pressure, and heart rate (HR) were recorded. Results The SVV was significant decreased with decreased slopes of operating table in T position, and increased with increased slopes of operating table in RT position (P = 0.000). Schematically, it was increased by 1% when the slope of operating table was increased by 5°. But, the CO and PAP were significant increased with decreased slopes of operating table in T position, and decreased with increased slopes of operating table in RT position (P = 0.045, 0.027). Conclusions SVV is subjected to the posture, and we should take these findings into account on reading SVV for fluid therapy.