Miracle-dz/UniFAR-FTUs huggingface dataset:
5-Lipoxygenase: Underappreciated Role of a Pro-Inflammatory Enzyme in Tumorigenesis

Leukotrienes constitute a group of bioactive lipids generated by the 5-lipoxygenase (5-LO) pathway. An increasing body of evidence supports an acute role for 5-LO products already during the earliest stages of pancreatic, prostate, and colorectal carcinogenesis. Several pieces of experimental data form the basis for this hypothesis and suggest a correlation between 5-LO expression and tumor cell viability. First, several independent studies documented an overexpression of 5-LO in primary tumor cells as well as in established cancer cell lines. Second, addition of 5-LO products to cultured tumor cells also led to increased cell proliferation and activation of anti-apoptotic signaling pathways. 5-LO antisense technology approaches demonstrated impaired tumor cell growth due to reduction of 5-LO expression. Lastly, pharmacological inhibition of 5-LO potently suppressed tumor cell growth by inducing cell cycle arrest and triggering cell death via the intrinsic apoptotic pathway. However, the documented strong cytotoxic off-target effects of 5-LO inhibitors, in combination with the relatively high concentrations of 5-LO products needed to achieve mitogenic effects in cell culture assays, raise concern over the assignment of the cause, and question the relationship between 5-LO products and tumorigenesis.
Measuring the Redshift Evolution of Clustering: the Hubble Deep Field South

ABSTRA C T We present an analysis of the evolution of galaxy clustering in the redshift interval 0 # z # 4:5 in the Hubble Deep Field South (HDF-South). The HST optical data are combined with infrared ISAAC/VLT observations, and photometric redshifts are used for all the galaxies brighter than IAB # 27:5. The clustering signal is obtained in different redshift bins using two different approaches: a standard one, which uses the best redshift estimate of each object, and a second one, which takes into account the redshift probability function of each object. This second method makes it possible to improve the information in the redshift intervals where contamination from objects with insecure redshifts is important. With both methods, we find that the clustering strength up to z . 3:5 in the HDF-South is consistent with the previous results in the HDF-North. Whereas at redshift lower than z , 1 the HDF galaxy population is un/anti-biasedOb # 1U with respect to the underlying dark matter, at high redshift the bias increases up to bOz , 3U . 2‐3, depending on the cosmological model. These results support previous claims that, at high redshift, galaxies are preferentially located in massive haloes, as predicted by the biased galaxy formation scenario. In order to quantify the impact of cosmic errors on our analyses, we have used analytical expressions from Bernstein. Once the behaviour of higher-order moments is assumed, our results show that errors in the clustering measurements in the HDF surveys are indeed dominated by pure shot-noise in most regimes, as assumed in our analysis. We also show that future observations with instruments like the Advanced Camera on HST will improve the signal-to-noise ratio by at least a factor of 2, as a consequence, more detailed analyses of the errors will be required. In fact, pure shot-noise will give a smaller contribution with respect to other sources of errors, such as finite volume effects or non-Poissonian discreteness effects.
Differential outcomes in triple negative breast cancer observed among the major ethnic groups in Singapore

Objectives: Although Triple Negative Breast Cancers (TNBCs) are known as a particularly aggressive subtype, some women have a favorable prognosis and recurrence after the initial few years is uncommon. In this study, we reviewed the outcome of women with TNBC and evaluated factors potentially useful for risk stratification. Methods: Retrospective review was performed of 345 patients diagnosed with TNBC at two local institutes from 2006 to 2011. Detailed analyses focused on 315 women without metastasis. Results: TNBC accounted for 11.3% of cancers diagnosed and was most prevalent among Indian women. Disease recurrence was a significant determinant of overall survival (P<0.001) and apart from the disease stage (P<0.001), it was independently associated with ethnicity (P=0.011). Recurrence was two-fold higher among Malay and Indian women compared to Chinese women (P=0.027) and 5-year recurrence-free survival was significantly shorter compared to Chinese women (P=0.031, HR 2.575, 95% CI 0.165 to 0.915; P=0.034, HR 2.090, 95% CI 0.514 to 0.929). On the other hand, 5-year recurrence-free survival was similar between Malay and Indian women (P=0.987). This survival difference could not be attributed to differences in disease factors or stage at presentation, and apart from more Malay women receiving radiation (P=0.020), due to higher rates of breast conservation in this group, the women all received similar treatments. Conclusions: Ethnicity and disease stage were identified as independent predictors of disease recurrence in women with TNBC, with Chinese women having better survival outcomes.
The Emergence of Environmental Homeostasis in Complex Ecosystems

The Earth, with its core-driven magnetic field, convective mantle, mobile lid tectonics, oceans of liquid water, dynamic climate and abundant life is arguably the most complex system in the known universe. This system has exhibited stability in the sense of, bar a number of notable exceptions, surface temperature remaining within the bounds required for liquid water and so a significant biosphere. Explanations for this range from anthropic principles in which the Earth was essentially lucky, to homeostatic Gaia in which the abiotic and biotic components of the Earth system self-organise into homeostatic states that are robust to a wide range of external perturbations. Here we present results from a conceptual model that demonstrates the emergence of homeostasis as a consequence of the feedback loop operating between life and its environment. Formulating the model in terms of Gaussian processes allows the development of novel computational methods in order to provide solutions. We find that the stability of this system will typically increase then remain constant with an increase in biological diversity and that the number of attractors within the phase space exponentially increases with the number of environmental variables while the probability of the system being in an attractor that lies within prescribed boundaries decreases approximately linearly. We argue that the cybernetic concept of rein control provides insights into how this model system, and potentially any system that is comprised of biological to environmental feedback loops, self-organises into homeostatic states.
Resource allocation for energy-efficient device-to-device communication in 4G networks

Device-to-device (D2D) communications as an underlay of a LTE-A (4G) network can reduce the traffic load as well as power consumption in cellular networks by way of utilizing peer-to-peer links for users in proximity of each other. This would enable other cellular users to increment their traffic, and the aggregate traffic for all users can be significantly increased without requiring additional spectrum. However, D2D communications may increase interference to cellular users (CUs) and force CUs to increase their transmit power levels in order to maintain their required quality-of-service (QoS). This paper proposes an energy-efficient resource allocation scheme for D2D communications as an underlay of a fully loaded LTE-A (4G) cellular network. Simulations show that the proposed scheme allocates cellular uplink resources (transmit power and channel) to D2D pairs while maintaining the required QoS for D2D and cellular users and minimizing the total uplink transmit power for all users.
Evaluation of a web-based self-compassion intervention to reduce student assessment anxiety.

Assessment anxiety is associated with excessive worry and cognitive disruption which can contribute to academic failure. Compassion-focused interventions have previously been effective in reducing anxiety, stress and depression among the general population. Aims: This study extended this approach to students whose academic achievement is potentially compromised by assessment anxiety, by evaluating a web-based compassionate imagery intervention. Students (n=48) who self-identified as assessment anxious were randomised to practice either compassionate imagery exercises or to a control condition of practicing relaxation exercises. Students completed measures of test anxiety, mastery and performance learning goals, self-compassion, self-criticism/self-reassurance, depression, anxiety and stress, before and after the two-week intervention. The compassionate imagery exercises improved self-compassion more than the control condition of relaxation exercises did. Both tasks improved students’ well being, and reduced assessment anxiety among those with higher baseline assessment anxiety. Webbased compassionate imagery and relaxation may offer cost-effective interventions for reducing assessment anxiety. More research is needed on the influence of selfcompassion on learning processes and academic performance and achievement. Received: November 09, 2017 Accepted: April 23, 2018 Published: May 04, 2018 Copyright: © 2018 McEwan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Corresponding author: Kirsten McEwan, University of Derby, Kedleston Road, Derby, DE22 1GB, UK E-mail: k.mcewan@derby.ac. uk Citation: McEwan, K. , Elander, J.,Gilbert, P. 2018. Evaluation of a web-based self-compassion intervention to reduce student assessment anxiety. Interdisciplinary Education and Psychology, 2(1):6. Open Access Interdisciplinary Education and Psychology 1 of 12 McEwan et al. Interdisciplinary Education and Psychology. 2018, 2(1):6.
Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved Druglike Properties

(−)-P7C3-S243 is a neuroprotective aminopropyl carbazole with improved druglike properties compared with previously reported compounds in the P7C3 class. It protects developing neurons in a mouse model of hippocampal neurogenesis and protects mature neurons within the substantia nigra in a mouse model of Parkinson’s disease. A short, enantioselective synthesis provides the neuroprotective agent in optically pure form. It is nontoxic, orally bioavailable, metabolically stable, and able to cross the blood–brain barrier. As such, it represents a valuable lead compound for the development of drugs to treat neurodegenerative diseases and traumatic brain injury.
A novel microfluidic platform for size and deformability based separation and the subsequent molecular characterization of viable circulating tumor cells

Circulating tumor cells (CTCs) were introduced as biomarkers more than 10 years ago, but capture of viable CTCs at high purity from peripheral blood of cancer patients is still a major technical challenge. Here, we report a novel microfluidic platform designed for marker independent capture of CTCs. The Parsortix™ cell separation system provides size and deformability‐based enrichment with automated staining for cell identification, and subsequent recovery (harvesting) of cells from the device. Using the Parsortix™ system, average cell capture inside the device ranged between 42% and 70%. Subsequent harvest of cells from the device ranged between 54% and 69% of cells captured. Most importantly, 99% of the isolated tumor cells were viable after processing in spiking experiments as well as after harvesting from patient samples and still functional for downstream molecular analysis as demonstrated by mRNA characterization and array‐based comparative genomic hybridization. Analyzing clinical blood samples from metastatic (n = 20) and nonmetastatic (n = 6) cancer patients in parallel with CellSearch® system, we found that there was no statistically significant difference between the quantitative behavior of the two systems in this set of twenty six paired separations. In conclusion, the epitope independent Parsortix™ system enables the isolation of viable CTCs at a very high purity. Using this system, viable tumor cells are easily accessible and ready for molecular and functional analysis. The system's ability for enumeration and molecular characterization of EpCAM‐negative CTCs will help to broaden research into the mechanisms of cancer as well as facilitating the use of CTCs as “liquid biopsies. ”
FITRAH-BASED EDUCATION

In the general concept of Islam, it is stated that primordial human nature (Fitrah in Arabic) is that human beings are born with an innate inclination of tawhid (Oneness). Existing creation and the natural structure has the fact that human beings are born with their natural belief of one God which is called tawhid religion. Islam, as a Fitrah religion, fits not only in men’s diversity but also supports their growth and development. This makes their existence completed with perfect personality. The concept of education on the basis of fitrah has two primary goals. Firstly, it is to trigger and encourage the development of good personality rooted from Fitrah of the students. The good personality has two main dimensions, which are social and personal dimension, which lead to self awareness. By having self awareness, students are expected to have fundamental potential which should be developed optimally. Secondly, it is to return back to th concept of Oneness so that the universe becomes a means of Zikr (devotional acts in Islam in which short phrases or prayers, glorifying Allah, are repeatedly recited silently within the mind or aloud) and learning sources for students. In line with the goals of the Fitrah concept in the islamic educational system, students’ Fitrah can be built correctly and perfectly as a moslem. A pious man who has great relationship with Allah SWT, other human beings, and nature positively and constructively is called Manusia yang beriman dan bertaqwa serta memiliki berbagai kemampuan aktualisasi hubungan dengan Allah swt, sesama manusia, dan alam secara positif konstruktif, inilah yang disebut transcedental humanism theocentric
Stability Analysis, Design and Application of Reset Control Systems

This paper investigates stability analysis and design of reset control systems of which the reset times are pre-specified. Firstly, in order to testify stability of reset control systems, we propose an approach which does not rely on the stability of base linear systems. Based on this, some Lie-algebraic conditions are also obtained. Then, we develop a method of reset law design which aims at improving transient response of the base linear systems. In addition, observer based design is also considered. We prove that under some mild conditions, reset controller and observer can be designed separately. The obtained results are applied to short-span seeking control of a kind of single stage hard disk drive servo systems. Simulations show that the proposed design is more capable of improving transient response than traditional one.
Meet iCAM: A Next-Generation Color Appearance Model

For over 20 years, color appearance models have evolved to the point of international standardization. These models are capable of predicting the appearance of spatially-simple color stimuli under a wide variety viewing conditions and have been applied to images by treating each pixel as an independent stimulus. It has been more recently recognized that revolutionary advances in color appearance modeling would require more rigorous treatment of spatial (and perhaps temporal) appearance phenomena. In addition, color appearance models are often more complex than warranted by the available visual data and limitations in the accuracy and precision of practical viewing conditions. Lastly, issues of color difference measurement are typically treated separate from color appearance. Thus, the stage has been set for a new generation of color appearance models. This paper presents one such model called iCAM, for image color appearance model. The objectives in formulating iCAM were to simultaneously provide traditional color appearance capabilities, spatial vision attributes, and color difference metrics, in a model simple enough for practical applications. The framework and initial implementation of the model are presented along with examples that illustrate its performance for chromatic adaptation, appearance scales, color difference, crispening, spreading, high-dynamic-range tone mapping, and image quality measurement. It is expected that the implementation of this model framework will be refined in the coming years as new data become available.
IMPACT OF PARTICIPATIVE LEADERSHIP AND EMPLOYEE VOICE THROUGH CONSCIENTIOUSNESS ON ORGANIZATIONAL EFFECTIVENESS: 3-TIME LAGGED STUDY ON BANKING SECTOR OF PAKISTAN

Drawing on trait activation theory, we hypothesize that participative leadership directly and positively affect organizational effectiveness. This model has been tested through 3-time lagged study design. On time 1 independent variable and moderator have been tested. At time 2 intermediary variable and on the 3rd time dependent variable is tested. Results of the study have confirmed that the participative leadership has a positive influence on organizational effectiveness used as an outcome variable and it has indirect influence through employee voice. The mediation analysis is also significant with employee voice as an intermediary variable. Result shows the indirect path is stronger in the presence of people having high conscientious trait and insignificant for individuals having low trait. In the end limitations, future directions for research besides theoretical and practical implications of the current study are discussed
Successive Interference Cancelers for Multimedia Multicode DS-CDMA Systems Over Frequency-Selective Fading Channels

Noncoherent and coherent multicode direct-sequence code-division multiple access (DS-CDMA) systems with successive interference cancellation (SIC) for multimedia reverse links over frequency-selective fading channels are studied. Followed by a RAKE receiver, the SIC scheme is applied for combating the multiple access interference. The bit error rate (BER) using the SIC technique over Nakagami-m fading channels is derived. Simulation results show that the multicode DS-CDMA system with SIC has demonstrated better performance than that without SIC under the multipath fading environment, while their corresponding numerical results from performance analyses are also provided for verifications. Furthermore, the coherent receiver could achieve a more satisfactory BER than the noncoherent counterpart at the expense of synchronization.
Democracy or fellowship and participation with peers: what constitutes one’s choice to self-segregate?

ABSTRACT Democracy in an inclusive discourse in education relates to all children’s rights to comment upon and influence matters concerning their interest in education. The article’s empirical data are based on a girl categorised with intellectual disability who through her surroundings is granted the right to influence her physical placement in school, which results in her often choosing to segregate herself from the fellowship with peers. This creates a dilemma for the school, which is faced with the question of overruling her decision in favour of other aspects of inclusion such as fellowship and participation or to continue supporting her decision to segregate. Based on theoretical contributions by Ian Hacking and Lev Vygotskij, this article discusses how schools and teachers approach children that are categorised as intellectually disabled and how the category influences the construction of their identity. Further, constructions of identity govern how the child views themselves and their surroundings. How they understand themselves in relation to the context and situations they are part of will ultimately affect what needs, wishes and compensation strategies the child develops. Studying the structures at play might contribute to further understanding about what causes a child to decide in a manner that conflicts with dimensions of inclusion.
A population of very young brown dwarfs and free‐floating planets in Orion

We describe the results of a very deep imaging survey of the Trapezium cluster in the IJH bands, using the UKIRT high-resolution camera UFTI. Approximately 32 per cent of the 515 point sources detected are brown dwarf candidates, including several free-floating objects with masses below the deuterium-burning (planetary) threshold at 0.013 M⊙, which are detectable because of their extreme youth. We have confidence that almost all the sources detected are cluster members, since foreground contamination is minimal in the 33-arcmin2 area surveyed, and the dense backdrop of OMC-1 obscures all background stars at these wavelengths. Extinction is calculated from the (J−H) colours, permitting accurate luminosity estimates, and temperatures are derived from the dereddened (I−J) colours. There is some evidence for a cut-off in the luminosity function below the level corresponding to several Jupiter masses, which may represent the bottom end of the initial mass function. Since star formation is complete in the Trapezium, this limit could have wide significance, if confirmed. However, it could well be an effect of the dispersal of the molecular cloud by the central O-type stars, a process for which the time-scale will vary between star formation regions.
Classes in Translating and Interpreting Produce Differential Gains in Switching and Updating

The present longitudinal study was intended to investigate whether the two bilingual experiences of written translation and consecutive interpreting (featured with similar language switching experience but different processing demands) would produce different cognitive control effects in young adults. Three groups of Chinese–English young adult bilinguals, who differed mainly in their half-year long bilingual experience: one for general L2 training, one for written translation and one for oral consecutive interpreting, were tested twice on the number Stroop, switching color-shape and N-back tasks. The results show that the interpreting experience produced significant cognitive advantages in switching (switch cost) and updating, while the translating experience produced marginally significant improvements in updating. The findings indicate that the experience of language switching under higher processing demands brings more domain-general advantages, suggesting that processing demand may be a decisive factor for the presence or absence of the hot-debated bilingual advantages.