Miracle-dz/UniFAR-FTUs huggingface dataset:
Strength and Mechanics of Bonded Scarf Joints for Repair of Composite Materials

Experimental and analytical investigations of scarf joints indicate that slight bluntness of adherend tips induces adhesive stress concentrations which significantly reduce joint strength, and the stress distribution through the adhesive thickness is non-uniform and has significant stress concentrations at the ends of the joint. The laminate stacking sequence can have important effects on the adhesive stress distribution. A significant improvement in joint strength is possible by increasing overlap at the expense of raising the repair slightly above the original surface. Although a surface grinder was used to make most experimental specimens, a hand held rotary bur can make a surprisingly good scarf. Scarf joints wit doublers on one side, such as might be used for repair, bend under tensile loads and may actually be weaker than joints without doublers.
Exploiting Timelines to Enhance Multi-document Summarization

We study the use of temporal information in the form of timelines to enhance multidocument summarization. We employ a fully automated temporal processing system to generate a timeline for each input document. We derive three features from these timelines, and show that their use in supervised summarization lead to a significant 4.1% improvement in ROUGE performance over a state-of-the-art baseline. In addition, we propose TIMEMMR, a modification to Maximal Marginal Relevance that promotes temporal diversity by way of computing time span similarity, and show its utility in summarizing certain document sets. We also propose a filtering metric to discard noisy timelines generated by our automatic processes, to purify the timeline input for summarization. By selectively using timelines guided by filtering, overall summarization performance is increased by a significant 5.9%.
A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region.

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with a multifactorial genetic basis. However, pathogenic genes for RA other than the human leukocyte antigen (HLA)-DRB1 gene have yet to be identified. Here, we investigated whether there is a second susceptibility locus for RA within the human major histocompatibility complex using 18 microsatellite markers distributed from the centromeric (HSET) to the telomeric end (P5-15) of the 3.6-Mb HLA region. Statistical studies of associated alleles on each microsatellite locus showed that one pathogenic gene for RA in the HLA region is localized in the DRB1 gene, as expected. Further, a second susceptibility gene of RA was suggested to be present in the HLA class III region, narrowed to 70 kb, that is just telomeric of the TNF gene cluster (TNFA and LTA) and that is located between the microsatellites TNFa and C1-2-A. In this critical segment, four expressed genes have been thus far identified, NFKBIL1 (IkappaBL), ATP6G, BAT1, and MICB, all of which are candidate genes for determining susceptibility to RA. These results exclude the possibility of involvement of the TNFA genes (TNF-alpha) in the development of RA, which was suggested previously to be a strong candidate for RA in the class III region.
Rapid method for fluorescent in situ ribosomal RNA labelling of Cryptosporidium parvum

A method for fluorescence in situ hybridization (FISH) is described that requires less than 1 h duration. Oocysts were resuspended in 50% ethanol and incubated at 80°C for 10 min for simultaneous fixation and permeabilization. Samples were then incubated with the oligonucleotide probe at 48 °C for more than 30 min. The rRNA binding specificity of the optimized protocol was confirmed. FISH was found to be valuable as a second label for oocysts presumptively identified immunofluorescently, but required more than an order of magnitude signal amplification for independent use. The number of oligonucleotide probes bound per oocyst was compared with the copy number of 18S rRNA molecules per oocyst to provide a measure of the labelling efficiency of the FISH method. Hybridization kinetics were also analysed. These data indicate that significant further increases in the brightness of FISH‐labelled oocysts cannot be achieved by further optimization of the pre‐treatment and hybridization conditions.
Mixed‐Mode Slip Behavior of the Altotiberina Low‐Angle Normal Fault System (Northern Apennines, Italy) through High‐Resolution Earthquake Locations and Repeating Events

We generated a 4.5‐year‐long (2010–2014) high‐resolution earthquake catalogue, composed of ~37,000 events with ML < 3.9 and MC = 0.5 completeness magnitude, to report on the seismic activity of the Altotiberina (ATF) low‐angle normal fault system and to shed light on the mechanical behavior and seismic potential of this fault, which is capable of generating a M7 event. Seismicity defines the geometry of the fault system composed of the low‐angle (15°–20°) ATF, extending for ~50 km along strike and between 4 and 16 km at depth showing an ~1.5 km thick fault zone made of multiple subparallel slipping planes, and a complex network of synthetic/antithetic higher‐angle segments located in the ATF hanging wall (HW) that can be traced along strike for up to 35 km. Ninety percent of the recorded seismicity occurs along the high‐angle HW faults during a series of minor, sometimes long‐lasting (months) seismic sequences with multiple MW3+ mainshocks. Remaining earthquakes (ML < 2.4) are released instead along the low‐angle ATF at a constant rate of ~2.2 events per day. Within the ATF‐related seismicity, we found 97 clusters of repeating earthquakes (RE), mostly consisting of doublets occurring during short interevent time (hours). RE are located within the geodetically recognized creeping portions of the ATF, around the main locked asperity. The rate of occurrence of RE seems quite synchronous with the ATF‐HW seismic release, suggesting that creeping may guide the strain partitioning in the ATF system. The seismic moment released by the ATF seismicity accounts for 30% of the geodetic one, implying aseismic deformation. The ATF‐seismicity pattern is thus consistent with a mixed‐mode (seismic and aseismic) slip behavior.
Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer

Whilst the near instantaneous physical interaction of radiation energy with living cells leaves little opportunity for inter-individual variation in the initial yield of DNA damage, all the downstream processes in how damage is recognized, repaired or resolved and therefore the ultimate fate of cells can vary across the population. In the clinic, this variability is observed most readily as rare extreme sensitivity to radiotherapy with acute and late tissue toxic reactions. Though some radiosensitivity can be anticipated in individuals with known genetic predispositions manifest through recognizable phenotypes and clinical presentations, others exhibit unexpected radiosensitivity which nevertheless has an underlying genetic cause. Currently, functional assays for cellular radiosensitivity represent a strategy to identify patients with potential radiosensitivity before radiotherapy begins, without needing to discover or evaluate the impact of the precise genetic determinants. Yet, some of the genes responsible for extreme radiosensitivity would also be expected to confer susceptibility to radiation-induced cancer, which can be considered another late adverse event associated with radiotherapy. Here, the utility of functional assays of radiosensitivity for identifying individuals susceptible to radiotherapy-induced second cancer is discussed, considering both the common mechanisms and important differences between stochastic radiation carcinogenesis and the range of deterministic acute and late toxic effects of radiotherapy.
Understanding unintentional injury risk in young children II. The contribution of caregiver supervision, child attributes, and parent attributes.

OBJECTIVE To identify child and parent attributes that relate to caregiver supervision and examine how these factors influence child-injury risk. METHODS Mothers completed diary records about supervision of their young child (2-5 years) when at home. Standardized questionnaires provided information about child attributes, maternal attributes, and children's history of injuries. RESULTS Correlations revealed that child attributes and parent attributes related both to actual maternal supervision and child-injury scores. Regression analyses to predict injury scores revealed child-temperament factors alone predicted all levels of severity (minor, moderately severe, and medically attended), but parent supervision also contributed to predict medically attended injuries. CONCLUSIONS Both child and parent factors influenced caregiver's supervision of young children at home and related to child-injury risk. For medically attended injuries, child attributes and parent supervision both predicted risk, whereas for less serious injuries, child factors alone determined risk.
The multiple molecular structure of the M proteins of group A streptococci.

was hydrolyzed in sealed vials with 6 N HCl at 100° for 20 hr. D-amino acids were determined by treating protein hydrolysates with purified D-amino acid oxidase (Worthington). '3 Control analyses of D-alanine added to hydrolysates of crystalline lysozyme were used to test the sensitivity of the method. Samples were applied to the amino acid analyzer before and after oxidase treatment to measure the decrease in amino acids (particularly alanine and lysine). Proteins were measured by the method of Lowry et al.,14 pentose by the method of Morse and Carter,"5 hexosamine by a modified method of Elson and Morgan,'6 and methyl pentose by the method of Dische and Shettles.17
Micro-Macro Schemes for Kinetic Equations Including Boundary Layers

We introduce a new micro-macro decomposition of collisional kinetic equations in the specific case of the diffusion limit, which naturally incorporates the incoming boundary conditions. The idea is to write the distribution function $f$ in all its domain as the sum of an equilibrium adapted to the boundary (which is not the usual equilibrium associated with $f$) and a remaining kinetic part. This equilibrium is defined such that its incoming velocity moments coincide with the incoming velocity moments of the distribution function. A consequence of this strategy is that no artificial boundary condition is needed in the micro-macro models and the exact boundary condition on $f$ is naturally transposed to the macro part of the model. This method provides an “asymptotic preserving” numerical scheme that generates a very good approximation of the space boundary values at the diffusive limit, without any mesh refinement in the boundary layers. Our numerical results are in very good agreement with the exact so-c.
The glaciogenic origin of the Pleistocene calcareous dust in Argentina on the basis of field, mineralogical, textural, and geochemical analyses

Abstract Calcareous dust occurs in Argentina as layers and pockets closely associated with Pleistocene deposits and periglacial features from southernmost Patagonia to at least the Mendoza Precordillera and has been traditionally interpreted as a soil horizon resulting from postdepositional pedogenesis during interglacials. Detailed field and microscopic observations and sedimentological and geochemical analyses of more than 100 samples collected from lower to upper Pleistocene deposits between 51°S and 33°S and from near sea level to 2800 m asl allow us to interpret the dust as synchronous with the host sediment. All observations and analyses lead us to conclude that: (1) the cryogenic morphology and the chemical signatures of the calcite component show that the dust is glaciogenic, (2) the dust was carried by southeasterly Antarctic winds, and (3) it was deposited over most of southern and central Argentina. Field observations, geomorphic evidence, and radiocarbon dates suggest that the dust was deposited during several Pleistocene glacial episodes.
Black carbon over Mexico: the effect of atmospheric transport on mixing state, mass absorption cross-section, and BC/CO ratios

Abstract. A single particle soot photometer (SP2) was operated on the NCAR C-130 during the MIRAGE campaign (part of MILAGRO), sampling black carbon (BC) over Mexico. The highest BC concentrations were measured over Mexico City (sometimes as much as 2 μg/m3) and over hill-fires to the south of the city. The age of plumes outside of Mexico City was determined using a combination of HYSPLIT trajectories, WRF-FLEXPART modeling and CMET balloon tracks. As expected, older, diluted air masses had lower BC concentrations. A comparison of carbon monoxide (CO) and BC suggests a CO background of around 65 ppbv, and a background-corrected BC/COnet ratio of 2.89±0.89 (ng/m3-STP)/ppbv (average ± standard deviation). This ratio is similar for fresh emissions over Mexico City, as well as for aged airmasses. Comparison of light absorption measured with a particle soot absorption photometer (PSAP) and the SP2 BC suggests a BC mass-normalized absorption cross-section (MAC) of 10.9±2.1 m2/g at 660 nm (or 13.1 m2/g @ 550 nm, assuming MAC is inversely dependent on wavelength). This appears independent of aging and similar to the expected absorption cross-section for aged BC, but values, particularly in fresh emissions, could be biased high due to instrument artifacts. SP2-derived BC coating indicators show a prominent thinly-coated BC mode over the Mexico City Metropolitan Area (MCMA), while older air masses show both thinly-coated and thickly-coated BC. Some 2-day-old plumes do not show a prominent thickly-coated BC mode, possibly due to preferential wet scavenging of the likely-hydrophilic thickly-coated BC.
Inconsistencies in the risk classification of alien species and implications for risk assessment in the European Union

Invasive alien species (IAS) are species whose introduction or spread outside their native range threatens biological diversity, ecosystem functioning, economy, and/or public health. The recent European Union (EU) regulation on the management of IAS emphasizes the need for a consistent approach to alien species assessment that will underpin international measures for the early identification of newly introduced IAS followed by rapid action aimed at the prevention of introduction, spread, and negative impacts. The goals of the present study were (1) to present the risk classifications of 18 aquatic alien species for The Netherlands using the Invasive Species Environmental Impact Assessment protocol, (2) to compare these with available risk classifications made for countries spanning similar climatic and biogeographical regions to the EU, and (3) to provide explanations for inconsistencies between different risk classifications. Five species were classified as high risk: Carassius gibelio (Prussian carp), Cyprinus carpio (common carp), Sander lucioperca (pike-perch), Cabomba caroliniana (fanwort), and Dreissena rostriformis bugensis (quagga mussel). Of the 14 species with existing risk classifications for countries spanning similar climatic and biogeographical regions to the EU, all but two of the assessed species (C. gibelio and D. rostriformis bugensis) were classified inconsistently. Reasons for these inconsistencies are the application of different risk assessment schemes, application on a national rather than biogeographical scale, differences in the definition and application of criteria, differences in habitat availability, and uncertainties that are intrinsic to risk assessment methodologies. Approaches that increase transparency by highlighting these methodological aspects, normative choices, and uncertainties are vital to the legitimacy of any risk assessment method and will increase acceptance among decision makers, nature managers, and stakeholders.
A new, diminutive species of Catopsalis (Mammalia, Multituberculata, Taeniolabidoidea) from the early Paleocene of southwestern Alberta, Canada

Abstract. Multituberculates were among the most taxonomically diverse mammals of the early Paleocene, having survived the catastrophic Cretaceous-Paleogene mass extinction and radiating soon thereafter. Although their evolution during the early Paleocene saw the advent of increasingly specialized dentitions, multituberculates generally remained small, rarely exceeding body sizes greater than those of extant rabbits. A conspicuous exception is the Taeniolabidoidea, a primarily North American clade whose members include the largest multituberculates yet discovered. Taeniolabidoidea includes several genera, with one of these, Catopsalis, being speciose and geographically wide ranging. Until recently, the chronological succession of Catopsalis appeared to document a trend of increasing body size. We report here on a new species of Catopsalis from the early Paleocene of Alberta that violates this trend and suggests that the evolutionary history of Catopsalis is considerably more complex. Catopsalis kakwa new species is not only the smallest species of Catopsalis, but is the smallest taeniolabidoid so far discovered, with an estimated body mass between 400 g and 660 g. In contrast to previous studies, we used recently proposed regressions based on lower cheek tooth row length to estimate body masses for North American taeniolabidoids. Our results propose more modest body mass estimates, particularly for the largest taeniolabidoids. The occurrence of C. kakwa n. sp. in the late early Paleocene implies either a significant ghost lineage, or reversal of several characters, including body size, during the latter part of the early Paleocene; the more likely of these scenarios must await a better understanding of the phylogenetic position of C. kakwa n. sp.
Evaluating Delayed Climate Policy by Cost-Risk Analysis

Cost-Risk Analysis (CRA) is a method to mathematically deduce preferences in line with a climate target. CRA is a trade-off, where costs of mitigating greenhouse gas emissions are weighted against the risk of exceeding climate targets. CRA enables a community supporting climate targets to evaluate delayed climate policy with an arbitrary length because the scope of CRA is not restricted to solutions that do not violate the target. For the first time we apply this approach to the problem of delayed climate policy using the integrated assessment model MIND-L. The most important results of our analysis are: (i) Using the most conservative risk metric welfare losses double for a 40 year delay of climate policy, that initially aims at limiting global mean temperature rise to 2 °C with a probability of 66%. (ii) The welfare losses are only driven by an increase in temperature. Mitigation costs are even decreasing, which can be seen as an incentive to delay mitigation efforts for decision makers who ignore risk. (iii) For the 2°C target, we find that maximum mitigation is optimal for any delay scenario beyond 2020, in line with previous studies using other approaches.
The implicit fan cursor: a velocity dependent area cursor

We present the Implicit Fan Cursor (IFC) - a novel target pointing technique using a cursor with a fan-shape activation area. The IFC couples the cursor's activation area with its velocity, i.e., the speed and direction of the mouse motion, behaving like a 2D spotlight cursor at low speed and a circular area cursor at high speed. Thus, it enables the user to precisely acquire distant targets at low speed and easily acquire nearest targets at high speed, without explicit mode switching. This technique minimizes cursor movement, while taking into consideration of the precision of cursor movement at different speeds. It also ensures that only one target is captured at any time. The results of our controlled experiments show that the IFC outperforms the point cursor and the area cursor techniques, particularly in terms of cursor moving distance, and that its performance can be accurately modeled using the Fitts' law.
SPEAR Trial: Smartphone Pediatric ElectrocARdiogram Trial

Objectives Smartphone-enabled ECG devices have the potential to improve patient care by enabling remote ECG assessment of patients with potential and diagnosed arrhythmias. This prospective study aimed to assess the usefulness of pediatric ECG tracings generated by the AliveCor device (Oklahoma City, OK) and to assess user satisfaction. Study Design Enrolled pediatric patients with documented paroxysmal arrhythmia used the AliveCor device over a yearlong study period. Pediatric electrophysiologists reviewed all transmitted ECG tracings. Patient completed surveys were analyzed to assess user satisfaction. Results 35 patients were enrolled with the following diagnoses: supraventricular tachycardia (SVT, 57%), atrial fibrillation (AF, 11%), ectopic atrial tachycardia (EAT, 6%), atrial tachycardia (AT, 3%), and ventricular tachycardia (VT, 23%). A total of 238 tracings were received from 20 patients, 96% of which were of diagnostic quality for sinus rhythm, sinus tachycardia, SVT, and AF. 126 patient satisfaction surveys (64% from parents) were completed. 98% of the survey responses indicated that it was easy to obtain tracings, 93% found it easy to transmit the tracings, 98% showed added comfort in managing arrhythmia by having the device, and 93% showed interest in continued use of the device after the study period ended. Conclusions Smartphone-enabled ECG devices can generate tracings of diagnostic quality in children. User satisfaction was extremely positive. Use of the device to manage certain patients with AF and SVT showcases the future role of remote ECGs in the successful outpatient management of arrhythmias in children by potentially reducing Emergency Department visits and healthcare costs.
The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease

OBJECTIVE: To establish whether alterations of brain structures in Alzheimer's disease are associated with executive dysfunction. METHODS: Nineteen patients with Alzheimer's disease and 22 older control subjects underwent a comprehensive evaluation. The clock drawing test, digit span test, executive motor function test, Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test), and Stroop test were used to evaluate executive dysfunction. A multiparametric approach using the FreeSurfer image analysis suite provided a description of volumetric and geometric features of the gray matter structures. RESULTS: The cortical thickness maps showed a negative correlation between the Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test) and the right middle frontal gyrus; a positive correlation between the executive motor function test and the left superior parietal gyrus, left middle temporal gyrus, bilateral supramarginal gyri, right middle frontal gyrus, and right precuneus; a negative correlation between the Stroop test (part III) and the right superior parietal gyrus; and a negative correlation between the Stroop test (part III) and the right middle temporal gyrus. CONCLUSION: Executive dysfunction in Alzheimer's disease is correlated with alterations not only in the frontal areas but also within many temporal and parietal regions.