Miracle-dz/UniFAR-FTUs huggingface dataset:
Did Oral Interventions by the Indonesian Central Bank Support the Rupiah?

Most previous studies on the effectiveness of oral interventions (statements by officials in support of the exchange rate) focus on industrial countries. The present paper examines whether statements by Bank Indonesia officials (i.e. the central bank of Indonesia) during the period 2004–2007 have had any effect on the level and volatility of the rupiah–dollar exchange rate. Our exponential generalized autoregressive conditional heteroskedasticity models suggest that oral interventions have little impact on the level of the spot exchange rate, but increase the volatility of the spot exchange rate. Oral interventions indicating a stronger or weaker rupiah also have little influence on the level of the forward exchange rate while neutral statements lead to more volatility.
The dynamics of fertility, family planning and female education in a developing economy

Unlike most empirical works on fertility analysis, this study is the first attempt to analyse the dynamics of fertility and its determinants with a particular focus on the role played by female education and family planning programmes in the context of a traditional society. The analysis is based on the application of the following dynamic time-series techniques in a multivariate context: cointegration, vector error-correction modelling and variance decompositions. These ‘dynamic’ tools are recently developed and hitherto untried in fertility analysis in the context of a poor developing economy, such as India. The results based on the above most recently developed methodology, broadly indicate that in the complex dynamic interactions, the importance of conventional ‘structural’ hypothesis as a ‘Granger-causal’ factor in bringing fertility down in the longer term cannot be denied. However, overall, in the short to long term, the findings appear to be more consistent with the recent ‘ideational’ hypothesis (emphasizing the critical role played by the two policy variables in the analysis- i.e. changes in the female secondary enrolment ratios, and family planning programmes- to ensure ‘initial’ fertility decline) than with the conventional ‘structural’ hypothesis (emphasizing a significant socio-economic structural change as a pre-condition for ‘initial’ fertility decline).
Employer dilemma over disability employment policy in Thailand

This article analyses factors that present employers with a disability employment dilemma. Research on labour market discrimination among disabled jobseekers is abundant. However, very little is known about the reasons why employers cannot hire these people. It was noted that (i) the government passed disability laws and related regulations without sufficient study; (ii) universal design in society is not well placed; and (iii) the family always overprotects disabled members. These three major factors have demotivated disabled people. Despite strong intentions, employers fail to hire people with disabilities, while, at the same time, they are forced to pay into the Fund for Empowerment of Persons with Disabilities. Copyright © 2014 John Wiley & Sons, Ltd.
Learning through quality and innovation

This conceptual paper examines the role of knowledge and learning in the quality and innovation process, and proposes a holistic, cross‐disciplinary model of the learning approach to quality and innovation. It stresses the importance of creativity in the learning process and postulates a higher platform of quality and innovation: creative quality and value innovation. This will be necessary for sustaining competitive advantage in the hyper‐competitive world. The features and essentials in connection to the attainment of such a platform are tentatively constructed through the 5‐S model of creative quality and value innovation.
PROFILE OF A WINE TOURIST AND THE CORRESPONDENCE BETWEEN DESTINATION AND PREFERRED WINE: A STUDY IN ARAGON, SPAIN

Most of the existing characteristics of wine tourists have been based on the point of view of wineries or have been based on the tourists who have visited wineries. It is therefore necessary to establish a more general profile of wine tourists. In conjunction with this, a more in‐depth look must be taken at the motivations for visiting a destination. These motivations can include the production area of a preferred wine. The correspondence between the production area of a preferred wine and the destination selected by a tourist has been taken as a given in the research performed to date, but it has not been studied in depth. The results obtained show that the profile of a wine tourist can be divided into two groups, thereby considering the variables of gender, income, age, belonging to a wine club, wine consumption habits, and involvement in activities related to wine. Moreover, in the analyzed case there is positive correspondence between the place of origin of a preferred wine and the destination selected when participating in wine tourism.
Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells

Abstract Kallikrein 6 (KLK6) is a trypsin-like serine peptidase whose relevance in various types of cancers is currently being explored. Previous studies have shown that KLK6 mRNA is upregulated in colon and gastric cancers; however, the regulatory mechanisms and phenotypic consequences of this upregulation are largely unknown. Activating K-RAS mutations are common in colon cancer, occurring in approximately 50% of cases. We have recently reported the upregulation of KLK6 mRNA in Caco2 human colon cancer cells stably transfected with a mutant K-RAS allele (K-RASG12V). In this study we examined the pattern of K-RAS-dependent KLK6 expression and secretion in colon cancer cells. Using pharmacological inhibitors of pathways downstream of K-RAS, we could show that the PI3K and p42/44 MAPK pathways play an important role in the induction of KLK6 in mutant K-RAS-expressing colon cancer cells. Increased KLK6 expression enhanced colon cancer cell migration through laminin and Matrigel. Inhibition of KLK6 using small interference RNA treatment or a specific KLK6 antibody in Caco2 cells stably expressing the mutant K-RAS and in SW480 cells carrying a mutation in the K-RAS oncogene resulted in a reduction in invasiveness through cell culture inserts. These data support the oncogenic role of KLK6 in colorectal cancer.
Production and partial purification of Salmonella enterotoxin

By using a strain of Salmonella typhimurium, we detected the presence of an enterotoxin, as determined by the rabbit ileal loop assay, in various complex and defined media. The enterotoxin was concentrated by ultrafiltration of culture supernatant fluids and eluted in and adjacent to the void volume of a Sephadex G-100 column. This suggested that the enterotoxic factor was of a relatively high molecular weight, and additional evidence indicated it was heterogeneous in size. Further chromatography, using a diethylaminoethyl-cellulose anion exchanger, facilitated at least a 50-fold purification of the Salmonella enterotoxin.
Perceptions of Testicular Cancer and Testicular Self-Examination Among College Men

Testicular self-exam (TSE) is an important tool to prevent late-stage diagnosis of testicular cancer (TC). However, most young men remain unaware of their risk for TC despite a growing number of interventions promoting knowledge and awareness of the disease. Of those interventions, very few discuss perceived vulnerability, perceived value of health promotion, and/or preference for informational materials as viable predictors of behavioral change. In this study, 300 university males were surveyed on their perceptions of vulnerability, perceived value of health promotion methods, TC/TSE knowledge, and preference for health promotional information. The results indicated that men were generally unaware of TC and were unsure of their risk of developing the disease. Participants reported very positive responses to questions about the value of health promotion methods, particularly TSE, and indicated a high intention to perform health promotion behaviors. Most important, participants noted that they preferred personalized, tailored information to learn about TC and TSE. Significant predictors of intention to perform TSE include knowledge and awareness of TC/TSE, perceived value of health promotion, and attitudes. Significant predictors of promotional tool preferences differed among generalized pamphlets, personalized messages, and group training sessions. The authors recommend that researchers tailor promotional messages in TC/TSE awareness campaigns with an individual’s preference for promotional tool.
EARNINGS MANAGEMENT IN AN OVERLAPPING GENERATIONS MODEL

In this paper, I propose and analyze two reasons shareholders might not be inclined to eliminate the tendency for managers to engage in earnings management. The first motive is related to the stewardship value of accounting information. Once shareholders have determined which productive act they seek their management to implement, they must design a contract to encourage management to select that action. If shareholders' sole objective in designing the contract is to minimize the expected cost of inducing managers to select their preferred action, and the expected cost-minimizing contract encourages earnings management, then an "internal demand for earnings management" exists. In contrast, shareholders are said to have an "external demand for earnings management" if, holding managers' compensation and productive action fixed, they can improve their firm's contractual terms with outsiders by managing earnings. Though there are obviously several potential sources of such external demand (because of, e.g., accountingbased contracts with suppliers, debt-covenant restrictions, rate-of-return regulations), I analyze the external demand for earnings management induced by current shareholders' attempts to alter prospective investors' perceptions of the firm's value.
GARCH inadequacy for modelling exchange rates: empirical evidence from Latin America

This article checks for the adequacy of using GARCH models in exchange rate series. Using the Hinich portmanteau bicorrelation test, we find that a GARCH formulation or any of its variants fails to capture the data generating process of the main Latin American exchange rates. Our results highlight the potential of having misleading public policy when estimates are based in GARCH types of models. This article also complements recent similar findings encountered in European and Asian economies.
Poly-ε-Caprolactone Microsphere Polymers Containing Usnic Acid: Acute Toxicity and Anti-Inflammatory Activity

Usnic acid (UA) has been studied by its pharmacological properties; however, it presents moderate toxicity, low solubility, and absorption by biological membranes. The aim of this study was to develop poly-ε-caprolactone microsphere polymers containing UA (UA-micro) and evaluate their acute toxicity and anti-inflammatory activity. The microspheres were prepared by multiple emulsion technique (water/oil/water) and characterized by the encapsulation efficiency, particle size, polydispersity index, and zeta potential. The acute toxicity of UA and UA-micro (25–50 mg/kg; p.o.) was evaluated in mice. The anti-inflammatory activity of UA and UA-micro was evaluated by subcutaneous air pouch and carrageenan-induced paw edema in rat, with measurement of inflammatory cytokines and MPO levels. The UA presented encapsulation efficiency of 97.72%, particle size of 13.54 micrometers, polydispersity index of 2.36, and zeta potential of 44.5 ± 2.95 mV. The UA-micro presented lower acute toxicity (LD50 value up to 2000 mg/kg; p.o.) when compared to UA. UA-micro and UA (25 mg/kg) significantly reduced paw volume and decreased MPO levels, whereas only UA-micro (50 mg/kg) reduced significantly IL-1β, TNF-α, and NO levels in inflammatory exudate. These results suggest that controlled release systems, as microspheres, can be a promising alternative to reduce the toxicity of UA, making it a viable compound for inflammation therapy.
Decreased PD-1 Expression on CD8 Lymphocyte Subsets and Increase in CD8 Tscm Cells in Children with HIV Receiving Raltegravir.

We investigated the effect of combination antiretroviral therapy (cART) on immune recovery, particularly on the percentages of PD-1-positive cells within the major leukocyte subsets. Cryopreserved peripheral blood mononuclear cells and plasma samples collected longitudinally from a subset of 13 children and adolescents (between 9.7 and 18.2 years old) who were enrolled in the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1066 were used for this study. Immunophenotyping by flow cytometry was performed to determine the effect of raltegravir-containing cART regimen on the distribution of leukocyte populations, on the expression of PD-1 on T cell subpopulations, and on the expression of well-established markers of T cell activation (CD38 and HLA-DR) on CD8 T cells. C reactive protein (CRP), lipopolysaccharide (LPS), IL-6, and soluble CD163 were assayed in plasma samples by an enzyme-linked immunosorbent assay. Plasma viral loads were decreased in all subjects (by an average of 2.9 log units). The cART regimen, including raltegravir, induced changes in CD8 T cell subsets, consistent with an effective antiretroviral outcome and improved immunologic status, including increased percentages of CD8 stem cell memory T cells (Tscm). The percentages of CD8 PD-1-positive cells decreased significantly as compared with baseline levels. Among the proinflammatory markers measured in plasma, sCD163 showed a decline that was associated with cART. cART therapy, including raltegravir, over 48 weeks in children is associated with immune restoration, consistent with effective antiretroviral therapy, namely decreased percentages of PD-1+ CD8+ T cells, an increase in CD8 Tscm cells, and decreased levels of sCD163.
Mutual Monitoring in Teams: The Effects of Residual Claimancy and Reciprocity

Monitoring by peers in work teams, credit associations, partner- ships, local commons situations, and residential neighborhoods is often an effective means of attenuating incentive problems. Most explanations of the incentives to engage in mutual monitoring rely either on small group size or on a version of the Folk theorem with repeated interactions. We provide an explanation of mutual monitoring in single shot interactions among members of large teams. A key element of our approach is that when team members are residual claimants, some members are motivated by reciprocity norms to punish fellow members when they shirk. We provide evidence for the behavioral relevance of reciprocity norms and we explore the effects team size and the structure of information among team members on the efficacy of mutual monitoring. We conclude with some results specifying conditions under which mutual monitoring in teams provides an effective solution to incentive problems arising from incomplete contracting, as well as conditions under which mutual monitoring is likely to fail.
Determinants of Inflation in Poland: A Structural Cointegration Approach

Using cointegration and error-correction models, this paper analyses the relative impacts of the monetary, labour and foreign sectors on Polish inflation from 1990 to 1999. Following the development of a theoretical framework, we use a structural system approach in which cointegration relationships are used to derive deviations from steady-state levels. The deviations are interpreted as excess demand pressure on inflation in a given sector and subsequently incorporated in order to determine the short-run dynamics of Polish inflation. The results suggest that the labour and external sectors dominated the determination of Polish inflation during the above period, but their effects have been opposite since 1994. The appreciation of the domestic currency contributed to reducing inflation, while excessive wage increases prevented inflation from decreasing to a lower level. The monetary sector appears not to have exerted influence on inflation, suggesting monetary policy has been passive.
Why Most Published Results on Unit Root and Cointegration are False

The method of cointegration analysis for modeling nonstationary economic time series variables has become a dominant paradigm in empirical economic research. Critics argue that a cointegration analysis produces results that are, at best, useless and, at worst, dangerous. In this research, we explain why and how the use of a cointegration analysis in economic research will likely lead to findings and subsequent recommendations for public policy that will be unsound, misleading and potentially harmful. We recommend that, except for pedagogical review of policy failure of a historical magnitude, this method not be used in any analysis that affects public policy.
The Elasticity of Intertemporal Substitution Reconsidered

The elasticity of intertemporal substitution (EIS) is a crucial parameter in finance and macroeconomics, yet its estimation remains elusive. We show, based on Fisher's relation and the expectations theory of the term structure, that the EIS is the inverse of the product of the average term to maturity of debt instruments and the consumption-output ratio. Therefore, the EIS need not be estimated but can be calibrated from observable data.
Linking Unlearning with Work–Life Balance: An Initial Empirical Investigation into SMEs

The use of work–life balance () supporting cultures to provide and support the welfare of both the individuals and their families is expected to improve organizational outcomes by enabling company members to improve levels of job satisfaction and commitment to work. However, creating or introducing another culture in the company frequently generates internal problems when it conflicts with the current culture in terms of the beliefs, habits, and things managers take for granted. In this paper, we develop a framework for modeling how the unsuitable knowledge may be mitigated in order to strengthen a culture. It is based on the idea that the presence of an unlearning context that fosters the updating of knowledge is likely to be essential for small and medium‐sized enterprises (s) that are trying to implement a culture. The research model and hypothesized relationships are empirically tested using the structural equation modeling approach, validated by factor analysis of 229 s in the Spanish metal industry. Our findings show that in order to strengthen a WLB culture and thus positively influence innovation‐related outcomes, s meet the challenge of developing an unlearning context to counteract the negative effects of the outdated knowledge in relevant areas and to facilitate the replacement of out‐of‐date or obsolete knowledge.
Cash Flow and Accrual Surprises: Persistence and Return Implications

This paper investigates the return implications of the cash flows and accruals components of unexpected earnings. We find that unexpected cash flows have greater persistence than unexpected accruals and that this difference is driven primarily by loss firms. We also find that markets appear to react more (less) strongly to the unexpected cash flow (accrual) component of total unexpected earnings, but that only firms that beat both earnings expectations and cash flow expectations are rewarded with higher returns. These results are consistent with at least some fixation on the total earnings number, to the exclusion of more economically important cash flow surprises.
Compensating Wage Differentials versus Efficiency Wages: An Empirical Study of Job Autonomy and Wages

Efficiency wage theory as incorporated in the shirking model predicts that firms may substitute wage premiums for costly monitoring. This means that wage premiums should be expected for loosely monitored workers. By regarding extensive monitoring as a lack of job autonomy, efficiency wage theory predicts a positive relation between autonomy and wages. The theory of compensating wage differentials, however, predicts a negative relation between autonomy and wages. When workers prefer autonomous jobs, employers have to offer higher wages for less autonomous jobs in order to recruit labor. Swedish micro data are analyzed in order to examine the predictions of these theories. A proxy for the monitoring problem of the firm measures workers' possibilities of effort variation. Since this proxy is autonomy, it enables us to test the two rival hypotheses on the relation between job autonomy and wages. We find a positive relation in the private sector as predicted by the efficiency wage hypotheses and a negative relation in the case of the public sector, which accords with the theory of compensating wage differentials.
The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis.

OBJECTIVE Macrophage activation syndrome is characterized by an overwhelming inflammatory reaction driven by excessive expansion of T cells and hemophagocytic macrophages. Levels of soluble interleukin-2 receptor alpha (sIL-2Ralpha) and soluble CD163 (sCD163) may reflect the degree of activation and expansion of T cells and macrophages, respectively. This study was undertaken to assess the value of serum sIL-2Ralpha and sCD163 in diagnosing acute macrophage activation syndrome complicating systemic juvenile idiopathic arthritis (JIA). METHODS Enzyme-linked immunosorbent assay was used to assess sIL-2Ralpha and sCD163 levels in sera from 7 patients with acute macrophage activation syndrome complicating systemic JIA and 16 patients with untreated new-onset systemic JIA. The results were correlated with clinical features of established macrophage activation syndrome, including ferritin levels. RESULTS The median level of sIL-2Ralpha in the patients with macrophage activation syndrome was 19,646 pg/ml (interquartile range [IQR] 18,128), compared with 3,787 pg/ml (IQR 3,762) in patients with systemic JIA (P = 0.003). Similarly, the median level of sCD163 in patients with macrophage activation syndrome was 23,000 ng/ml (IQR 14,191), compared with 5,480 ng/ml (IQR 2,635) in patients with systemic JIA (P = 0.017). In 5 of 16 patients with systemic JIA, serum levels of sIL-2Ralpha or sCD163 were comparable with those in patients with acute macrophage activation syndrome. These patients had high inflammatory activity associated with a trend toward lower hemoglobin levels (P = 0.11), lower platelet counts, and significantly higher ferritin levels (P = 0.02). Two of these 5 patients developed overt macrophage activation syndrome several months later. CONCLUSION Levels of sIL-2Ralpha and sCD163 are promising diagnostic markers for macrophage activation syndrome. They may also help identify patients with subclinical macrophage activation syndrome.
An Analysis of Cooperative Bargaining in the Processing Tomato Industry

This article analyzes factors which affected the bargaining process and outcome of negotiations for the processing tomato industry in Indiana and Ohio during the 1966 growing season. Data obtained from Indiana and Ohio tomato processors, grower representatives, and growers was used to reconstruct the bargaining process to determine what factors were considered in establishing contract objectives, to determine various factors each party thought affected bargaining strength and the outcome of negotiations, and to measure attitudes about bargaining. Substantial differences were found between the parties' conception of supply and demand response and those estimated statistically. Processors and grower representatives underestimated supply response and consumers' response to higher prices. Significant differences between grower and processor attitudes toward bargaining were identified. Processors were primarily concerned about quality factors and growers with price. This suggests that a "trading off" of concessions would benefit both parties.