Miracle-dz/UniFAR-FTUs huggingface dataset:
A Transgenic Mouse Model for Studying the Role of the Parathyroid Hormone-Related Protein System in Renal Injury

Parathyroid hormone- (PTH-) related protein (PTHrP) and its receptor, the PTH1 receptor (PTH1R), are widely expressed in the kidney, where PTHrP exerts a modulatory action on renal function. PTHrP is known to be upregulated in several experimental nephropathies such as acute renal failure (ARF), obstructive nephropathy (ON) as well as diabetic nephropathy (DN). In this paper, we will discuss the functional consequences of chronic PTHrP overexpression in the damaged kidney using a transgenic mouse strain overexpressing PTHrP in the renal proximal tubule. In both ARF and ON, PTHrP displays proinflammatory and profibrogenic actions including the induction of epithelia to mesenquima transition. Moreover, PTHrP participates in the mechanisms of renal hypertrophy as well as proteinuria in experimental DN. Angiotensin II (Ang II), a critical factor in the progression of renal injury, appears to be, at least in part, responsible for endogenous PTHrP upregulation in these pathophysiological settings. These findings provide novel insights into the well-known protective effects of Ang II antagonists in renal diseases, paving the way for new therapeutic approaches.
Time lag between the initiation of adalimumab after methotrexate correlates with the efficacy of adalimumab in rheumatoid arthritis patients

Abstract Objectives: To evaluate the efficacy and safety of adalimumab (ADA) and methotrexate (MTX) in patients with rheumatoid arthritis (RA) and investigate critical factors associated with efficacy. Methods: In this retrospective cohort study, patients received ADA at a single facility. Clinical outcome was retrospectively evaluated using the Disease Activity Score in 28 joints with Erythrocyte Sedimentation Rate (DAS28-ESR). Results: Of the 122 patients undergoing treatment with ADA between July 2008 and April 2014, DAS28-ESR data after 6 months of treatment were available for 103 and 87 (84.5%) were treated with a combination of ADA and MTX. For combination therapy, time lag between MTX and the initiation of ADA significantly correlated with efficacy of ADA at 6 months, as well as prior use of biologics, but not disease duration. Conclusions: Clinical outcomes were correlated with the time lag between MTX and the initiation of ADA, not disease duration. Early initiation of ADA after MTX might improve clinical outcomes.
Mapping Quantitative Trait Loci Controlling High Iron and Zinc Content in Self and Open Pollinated Grains of Pearl Millet [Pennisetum glaucum (L.) R. Br.]

Pearl millet is a multipurpose grain/fodder crop of the semi-arid tropics, feeding many of the world’s poorest and most undernourished people. Genetic variation among adapted pearl millet inbreds and hybrids suggests it will be possible to improve grain micronutrient concentrations by selective breeding. Using 305 loci, a linkage map was constructed to map QTLs for grain iron [Fe] and zinc [Zn] using replicated samples of 106 pearl millet RILs (F6) derived from ICMB 841-P3 × 863B-P2. The grains of the RIL population were evaluated for Fe and Zn content using atomic absorption spectrophotometer. Grain mineral concentrations ranged from 28.4 to 124.0 ppm for Fe and 28.7 to 119.8 ppm for Zn. Similarly, grain Fe and Zn in open pollinated seeds ranged between 22.4–77.4 and 21.9–73.7 ppm, respectively. Mapping with 305 (96 SSRs; 208 DArT) markers detected seven linkage groups covering 1749 cM (Haldane) with an average intermarker distance of 5.73 cM. On the basis of two environment phenotypic data, two co-localized QTLs for Fe and Zn content on linkage group (LG) 3 were identified by composite interval mapping (CIM). Fe QTL explained 19% phenotypic variation, whereas the Zn QTL explained 36% phenotypic variation. Likewise for open pollinated seeds, the QTL analysis led to the identification of two QTLs for grain Fe content on LG3 and 5, and two QTLs for grain Zn content on LG3 and 7. The total phenotypic variance for Fe and Zn QTLs in open pollinated seeds was 16 and 42%, respectively. Analysis of QTL × QTL and QTL × QTL × environment interactions indicated no major epistasis.
Recovery of Ego-Motion Using Region Alignment

A method for computing the 3D camera motion (the ego-motion) in a static scene is described, where initially a detected 2D motion between two frames is used to align corresponding image regions. We prove that such a 2D registration removes all effects of camera rotation, even for those image regions that remain misaligned. The resulting residual parallax displacement field between the two region-aligned images is an epipolar field centered at the FOE (Focus-of-Expansion). The 3D camera translation is recovered from the epipolar field. The 3D camera rotation is recovered from the computed 3D translation and the detected 2D motion. The decomposition of image motion into a 2D parametric motion and residual epipolar parallax displacements avoids many of the inherent ambiguities and instabilities associated with decomposing the image motion into its rotational and translational components, and hence makes the computation of ego-motion or 3D structure estimation more robust.
Relative Size of Auditory Pathways in Symmetrically and Asymmetrically Eared Owls

Owls are highly efficient predators with a specialized auditory system designed to aid in the localization of prey. One of the most unique anatomical features of the owl auditory system is the evolution of vertically asymmetrical ears in some species, which improves their ability to localize the elevational component of a sound stimulus. In the asymmetrically eared barn owl, interaural time differences (ITD) are used to localize sounds in azimuth, whereas interaural level differences (ILD) are used to localize sounds in elevation. These two features are processed independently in two separate neural pathways that converge in the external nucleus of the inferior colliculus to form an auditory map of space. Here, we present a comparison of the relative volume of 11 auditory nuclei in both the ITD and the ILD pathways of 8 species of symmetrically and asymmetrically eared owls in order to investigate evolutionary changes in the auditory pathways in relation to ear asymmetry. Overall, our results indicate that asymmetrically eared owls have much larger auditory nuclei than owls with symmetrical ears. In asymmetrically eared owls we found that both the ITD and ILD pathways are equally enlarged, and other auditory nuclei, not directly involved in binaural comparisons, are also enlarged. We suggest that the hypertrophy of auditory nuclei in asymmetrically eared owls likely reflects both an improved ability to precisely locate sounds in space and an expansion of the hearing range. Additionally, our results suggest that the hypertrophy of nuclei that compute space may have preceded that of the expansion of the hearing range and evolutionary changes in the size of the auditory system occurred independently of phylogeny.
Learning Fair Representations via an Adversarial Framework

Fairness has become a central issue for our research community as classification algorithms are adopted in societally critical domains such as recidivism prediction and loan approval. In this work, we consider the potential bias based on protected attributes (e.g., race and gender), and tackle this problem by learning latent representations of individuals that are statistically indistinguishable between protected groups while sufficiently preserving other information for classification. To do that, we develop a minimax adversarial framework with a generator to capture the data distribution and generate latent representations, and a critic to ensure that the distributions across different protected groups are similar. Our framework provides a theoretical guarantee with respect to statistical parity and individual fairness. Empirical results on four real-world datasets also show that the learned representation can effectively be used for classification tasks such as credit risk prediction while obstructing information related to protected groups, especially when removing protected attributes is not sufficient for fair classification.
Effectiveness of switching from antipsychotic polypharmacy to monotherapy.

OBJECTIVE This randomized trial addressed the risks and benefits of staying on antipsychotic polypharmacy or switching to monotherapy. METHOD Adult outpatients with schizophrenia taking two antipsychotics (127 participants across 19 sites) were randomly assigned to stay on polypharmacy or switch to monotherapy by discontinuing one antipsychotic. The trial lasted 6 months, with a 6-month naturalistic follow-up. Kaplan-Meier and Cox regression analyses examined time to discontinuation of assigned antipsychotic treatment, and random regression models examined additional outcomes over time. RESULTS Patients assigned to switch to monotherapy had shorter times to all-cause treatment discontinuation than those assigned to stay on polypharmacy. By month 6, 86% (N=48) of those assigned to stay on polypharmacy were still taking both medications, whereas 69% (N=40) of those assigned to switch to monotherapy were still taking the same medication. Most monotherapy discontinuations entailed returning to the original polypharmacy. The two groups did not differ with respect to psychiatric symptoms or hospitalizations. On average, the monotherapy group lost weight, whereas the polypharmacy group gained weight. CONCLUSIONS Discontinuing one of two antipsychotics was followed by treatment discontinuation more often and more quickly than when both antipsychotics were continued. However, two-thirds of participants successfully switched, the groups did not differ with respect to symptom control, and switching to monotherapy resulted in weight loss. These results support the reasonableness of prescribing guidelines encouraging trials of antipsychotic monotherapy for individuals receiving antipsychotic polypharmacy, with the caveat that patients should be free to return to polypharmacy if an adequate trial on antipsychotic monotherapy proves unsatisfactory.
Passive avoidance learning in psychopathic and nonpsychopathic offenders.

Research on passive avoidance learning has demonstrated reliabledifferences between psychopaths and controls when avoidance errors result in electric shock but not in loss of money (Schmauk, 1970). Using monetary punishments, Newman, Widom, and Nathan (1985) found that psychopathic delinquents performed more poorly than controls in an experimental paradigm employing monetary reward as well as the avoidance contingency. The present study was conducted to replicate and extend these findings using adult psychopaths and a computer controlled task. Sixty white male prisoners were assigned to groups using Hare's (1980) Psychopathy Checklist and administered a "go/no-go" discrimination task involving monetary incentives. One condition entailed competing reward and punishment contingencies; the other, two punishment contingencies. As predicted, psychopaths made significantly more passive avoidance errors than nonpsychopaths when the task conmined competing goals (/9 < .05) but performed as well as controls when the subjects' only goal was avoiding punishment. Results corroborate earlier findings that psychopaths are relatively poor at learning to inhibit reward-seeking behavior that results in monetary punishment.
In situ hybridization demonstration of poly‐adenylated RNA sequences in formalin‐fixed paraffin sections using a biotinylated oligonucleotide poly d(T) probe

An in situ hybridization technique has been developed for assessing poly(A)+ RNA preservation in routine pathology specimens. The method detects poly‐adenylated RNA sequences in tissue sections using a biotinylated polydeoxythymidine poly d(T)) probe. The probe was prepared from single‐stranded 25–30 base oligo d(T) and was biotinylated using the enzyme terminal deoxynucleotide (ransferase with biotin‐11‐dUTP and dTTP in the ratio 1:4. The hybridization protocol uses varying concentrations of proteinase K to unmask mRNA sequences and the biotin labelled hybrids are demonstrated after hybridization under standard conditions by the application of streptavidin and biotinylated alkaline phosphatase. Alkaline phosphatase was visualized using a Fast Red naphthol‐capture method and the sections were counterstained with haematoxylin.
Bullous Pemphigoid

favorable results. We felt that with topical zinc therapy, the concentration of zinc could be significantly increased at the target organ, the sebaceous gland, with little systemic complication. This decision was based on the fact that zinc sulfate is known to be readily absorbed through the pilosebaceous apparatus. '" The average daily topical dose applied in this investigation was 20 mg, which corresponds approximately to the minimum daily requirement for zinc. Even if totally absorbed, this would not constitute a significant zinc body burden. This supplement to total body zinc would therefore allow only for a maximal local effect and a minimal systemic addition. This was apparent by the fact that there was not a significant increase in the zinc serum level over time for any of the patients.
A systematic literature review on first aid provided by laypeople to trauma victims

Death from trauma is a significant and international problem. Outcome for patients suffering out‐of‐hospital cardiac arrests is significantly improved by early cardiopulmonary resuscitation. The usefulness of first aid given by laypeople in trauma is less well established. The aim of this study was to review the existing literature on first aid provided by laypeople to trauma victims and to establish how often first aid is provided, if it is performed correctly, and its impact on outcome. A systematic review was carried out, according to preferred reporting items for systematic reviews and meta‐analysis (PRISMA) guidelines, of all studies involving first aid provided by laypeople to trauma victims. Cochrane, Embase, Medline, Pubmed, and Google Scholar databases were systematically searched. Ten eligible articles were identified involving a total of 5836 victims. Eight studies were related to patient outcome, while two studies were simulation based. The proportion of patients who received first aid ranged from 10.7% to 65%. Incorrect first aid was given in up to 83.7% of cases. Airway handling and haemorrhage control were particular areas of concern. One study from Iraq investigated survival and reported a 5.8% reduction in mortality. Two retrospective autopsy‐based studies estimated that correct first aid could have reduced mortality by 1.8–4.5%. There is limited evidence regarding first aid provided by laypeople to trauma victims. Due to great heterogeneity in the studies, firm conclusions can not be drawn. However, the results show a potential mortality reduction if first aid is administered to trauma victims. Further research is necessary to establish this.
A General Suspiciousness Metric for Dense Blocks in Multimodal Data

Which seems more suspicious: 5,000 tweets from 200 users on 5 IP addresses, or 10,000 tweets from 500 users on 500 IP addresses but all with the same trending topic and all in 10 minutes? The literature has many methods that try to find dense blocks in matrices, and, recently, tensors, but no method gives a principled way to score the suspiciouness of dense blocks with different numbers of modes and rank them to draw human attention accordingly. Dense blocks are worth inspecting, typically indicating fraud, emerging trends, or some other noteworthy deviation from the usual. Our main contribution is that we show how to unify these methods and how to give a principled answer to questions like the above. Specifically, (a) we give a list of axioms that any metric of suspicousness should satisfy, (b) we propose an intuitive, principled metric that satisfies the axioms, and is fast to compute, (c) we propose CROSSSPOT, an algorithm to spot dense regions, and sort them in importance ("suspiciousness") order. Finally, we apply CROSSSPOT to real data, where it improves the F1 score over previous techniques by 68% and finds retweet-boosting in a real social dataset spanning 0.3 billion posts.
Hidden Markov Models for Video Skim Generation

In this paper we present a statistical framework based on hidden Markov models (HMMs) for video skimming. A chain of HMMs is used to model subsequent story units: HMM states represent different visual-concepts, transitions model the temporal dependencies in each story unit, and stochastic observations are given by single shots. The skim is generated as an observation sequence, where, in order to privilege more informative segments for entering the skim, dynamic shots are assigned higher probability of observation. The effectiveness of the method is demonstrated on a video set from different kinds of programmes, and results are evaluated in terms of metrics that assess the content representational value of the obtained video skims.
An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro

The Kae1 (Kinase-associated endopeptidase 1) protein is a member of the recently identified transcription complex EKC and telomeres maintenance complex KEOPS in yeast. Kae1 homologues are encoded by all sequenced genomes in the three domains of life. Although annotated as putative endopeptidases, the actual functions of these universal proteins are unknown. Here we show that the purified Kae1 protein (Pa-Kae1) from Pyrococcus abyssi is an iron-protein with a novel type of ATP-binding site. Surprisingly, this protein did not exhibit endopeptidase activity in vitro but binds cooperatively to single and double-stranded DNA and induces unusual DNA conformational change. Furthermore, Pa-Kae1 exhibits a class I apurinic (AP)-endonuclease activity (AP-lyase). Both DNA binding and AP-endonuclease activity are inhibited by ATP. Kae1 is thus a novel and atypical universal DNA interacting protein whose importance could rival those of RecA (RadA/Rad51) in the maintenance of genome integrity in all living cells.
Cardiovascular effects of acute hyperglycaemia: pathophysiological underpinnings

High admission blood glucose levels after acute myocardial infarction are common and are associated with an increased risk of death in subjects with and without diabetes. In this review, the possible toxic effects of acute hyperglycaemia are discussed as a possible explanation for the worse prognosis in subjects with myocardial infarction and concomitant hyperglycaemia. In particular, evidence supporting the hypothesis that acute hyperglycaemia may favour the appearance of cardiovascular disease through the generation of oxidative stress is presented.
GSTM1-null and GSTA1-low activity genotypes are associated with enhanced oxidative damage in bladder cancer

Abstract Objectives To examine the association between gene variants of the detoxifying and antioxidant enzymes glutathione transferase M1 (GSTM1) and glutathione transferase A1 (GSTA1) and the extent of oxidative damage in patients with transitional cell carcinoma (TCC) of the urinary bladder. Methods GSTM1 deletion polymorphism was identified by polymerase chain reaction, and the restriction fragment length polymorphism method was used for the single nucleotide polymorphism of GSTA1. Enzyme immunoassay was used to determine markers of DNA (8-hydroxy-2′-deoxyguanosine, 8-OHdG) and lipid (8-epiprostaglandin F2α) oxidative damage in the urine of 80 TCC patients and 60 age-matched controls. Results Urinary 8-OHdG and 8-epi-prostaglandin F2α concentrations in TCC patients were significantly higher than in controls (P = 0.043 and 0.001, respectively). GSTM1 and GSTA1 polymorphisms influence vulnerability to both DNA and lipid oxidation, with the GSTM1-null gene variant having a more pronounced effect. A significant effect of combined GSTM1 and GSTA1 genotypes on the extent of oxidative damage was found only for 8-OHdG (P = 0.018). In addition, TCC patients with the most malignant tumors exhibited significantly higher frequencies of GSTM1-null or GSTA1-low activity genotypes, associated with a twofold increase in urinary 8-OHdG concentration (P = 0.044). Conclusions Our results suggest that absent GSTM1 or reduced GSTA1 antioxidant activity may increase the accumulation of oxidative DNA damage, thereby contributing to the malignant potential of TCC.
Structure of Ultra-Thin Diamond-Like Carbon Films Grown with Filtered Cathodic Arc on Si(001)

The structure of 3 nm and 15 nm diamond-like carbon films, grown on Si(001) by filtered cathodic arc, was studied by angle-resolved X-ray photoelectron spectroscopy (ARXPS) and transmission electron microscopy (TEM). The ARXPS data was deconvolved by employing simultaneous-fitting, which allowed for a clear deconvolution of the Si 2p and C 1s spectra into their different chemical contributions. An analysis of the take-off angle dependence of the peak intensities allowed for an independent identification of the physical origin of the chemical species. It was shown that the C 1s peak at 283.3 eV and the Si 2p peak at 99.6 eV correspond to SiC, and that the C/Si interface of the 3 nm film consists of a stoichiometric ~1 nm SiC layer. To quantify the sp^3-sp^2 ratio it was necessary to take into account not only their associated C 1s XPS-peak intensities, but also their take-off angle dependence. The thickness of the films obtained through ARXPS closely agrees with cross-sectional TEM images.
Blockchain-Free Cryptocurrencies. A Rational Framework for Truly Decentralised Fast Transactions

We present a radical solution to the two foremost challenges facing “blockchain”-based cryptocurrencies: (1) “mining pool” oligopolies and (2) incompressibility of delays affecting validation. Both problems stem from the Blockchain mechanism itself, which drives participants into a winner-takes-all global contest that amounts to a low-odds high-variance rewards lottery. Our proposal strips out the “blocks”-&-“chain” consolidation mechanism, instead repurposing the atomic transactions as the only system objects. A fully distributed proof of work, coupled with progressive and predictable rewards, is efficiently layered on top of the transaction structure. Without blocks, the cryptographic “chain” of transaction affirmations turns into a directed graph, whose sparseness, timely growth and global convergence are steered by game-theoretic incentives. The transaction affirmation process is cooperative (rather than competitive), to entice all participants to work solitarily at their own pace, rather than in pools at the pace of a blockchain. In the absence of blocks, we develop a framework that enjoys better decentralisation, improved responsiveness and natural scalability. Crucially, most of the key features of cryptocurrencies are transaction-bound rather than blockchain-bound, and are thus compatible with our framework—e.g., scripting, multi denominations, smart contracts, etc.
Methyl bromide.

At room temperature methyl bromide is a colourless gas, and in low concentrations odourless. It is used as a reaction gas in ionization chambers, for defatting wool and for extracting fats and ethereal oils from nuts, seeds and flowers. It is mainly used, however, as a fumigant in the production, improvement, storage and transport of foodstuffs; such fumigation is prescribed for export of the goods to various countries (e.g. the USA) (see GefStoffV 2003, § 15d). Another important application is in the disinfection of soil. Its use as a fire-extinguishing agent is obsolete (Budavari 1989, Hallier 1996).