Miracle-dz/UniFAR-FTUs huggingface dataset:
A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment

The retinoic acid (RA) signal, produced locally from vitamin A by retinaldehyde dehydrogenase (Raldh) and transduced by the nuclear receptors for retinoids (RA receptor and 9-cis-RA receptor), is indispensable for ontogenesis and homeostasis of numerous tissues. We demonstrate that Raldh3 knockout in mouse suppresses RA synthesis and causes malformations restricted to ocular and nasal regions, which are similar to those observed in vitamin A-deficient fetuses and/or in retinoid receptor mutants. Raldh3 knockout notably causes choanal atresia (CA), which is responsible for respiratory distress and death of Raldh3-null mutants at birth. CA is due to persistence of nasal fins, whose rupture normally allows the communication between nasal and oral cavities. This malformation, which is similar to isolated congenital CA in humans and may result from impaired RA-controlled down-regulation of Fgf8 expression in nasal fins, can be prevented by a simple maternal treatment with RA.
Minimizing the Probability of Lifetime Ruin with Deferred Life Annuities

Abstract We find the minimum probability of lifetime ruin of an investor who can invest in a market with a risky and a riskless asset and who can purchase a deferred life annuity. Although we let the admissible set of strategies of annuity purchasing process be the set of increasing adapted processes, we find that the individual will not buy a deferred life annuity unless she can cover all her consumption via the annuity and have enough wealth left over to sustain her until the end of the deferral period.
Multivariate Customer Demand: Modeling and Estimation from Censored Sales

Demand modeling and forecasting is important for inventory management, retail assortment and revenue management applications. Current practice focuses on univariate demand forecasting, where models are built separately for each product. However, in many industries there is empirical evidence of correlated product demand. In addition, demand is usually observed in several periods during a selling horizon, and it may be truncated due to inventory constraints so that in practice only censored sales data are recorded. Ignoring the inter-product demand correlation or the serial correlation of demand from one selling period to the next leads to biased and inefficient estimates of the true demand distributions. In this paper we propose a class of models for multi-product multiperiod aggregate demand forecasting. We develop an approach for estimating the parameters of the demand models from censored sales data in a maximum likelihood framework using the Expectation-Maximization (EM) algorithm. Through a simulation study, we show that the algorithm is computationally attractive and leads to maximum likelihood estimates with good properties, under different demand and censoring scenarios. We exemplify the methodology with the analysis of two booking data sets from the entertainment and the airline industries, and show that the use of these models in a revenue management setting for airlines increases the revenue by up to 11% relative to the use of alternative demand forecasting methods.
Evaluating change in attitude towards mathematics using the 'then-now' procedure in a cooperative learning programme.

BACKGROUND Tertiary students' attitudes to mathematics are frequently negative and resistant to change, reflecting low self-efficacy. Some educators believe that greater use should be made of small group, collaborative teaching. However, the results of such interventions should be subject to assessments of bias caused by a shift in the frame of reference used by students in reporting their attitudes. AIMS This study was designed to assess whether traditional pretest-post-test procedures would indicate positive changes in mathematics attitude during a programme of cooperative learning, and whether an examination of any attitudinal change using the 'then-now' procedure would indicate bias in the results due to a shift in the internal standards for expressing attitude. SAMPLE Participants were 141 undergraduate students enrolled in a 12-week statistics and research design component of a course in educational psychology. METHOD Using multivariate procedures, pretest, post-test, and then-test measures of mathematics self-concept and anxiety were examined in conjunction with a cooperative learning approach to teaching. RESULTS Significant positive changes between pretest and post-test were found for both mathematics self-concept and mathematics anxiety. There were no significant differences between the actual pretest and retrospective pretest measures of attitude. The results were not moderated by prior level of mathematics study. CONCLUSION Conclusions about the apparent effectiveness of a cooperative learning programme were strengthened by the use of the retrospective pretest procedure.
Detectability of small and flat polyps in MDCT colonography using 2D and 3D imaging tools: results from a phantom study.

OBJECTIVE The objective of this phantom study was to determine the performance of MDCT colonography for the detection of small polyps under ideal imaging conditions and to determine the added value of 3D imaging when used as an adjunct to 2D imaging. MATERIALS AND METHODS Thirty-six polypoid and 39 flat polyps (44 lesions, 2-5 mm; 31 lesions, 6-8 mm) were placed in three explanted segments of a thoroughly cleaned porcine colon (overall length, 4.5 m) that was distended with air and submerged in a water phantom. MDCT data sets with 4 x 1 mm collimation and 6-mm table feed were reconstructed every 0.7 mm with 1.25-mm effective slice width. The data were reviewed by three radiologists using 2D images in all three projections and with 3D volume-rendered images available as an adjunct to the 2D images. RESULTS Additional 3D as a problem-solving tool significantly increased the overall sensitivity (96% vs 90%), decreased the total number of false-positive calls (n = 9 vs n = 5), and increased the diagnostic confidence level (p < 0.03) compared with 2D images alone. Small polyps less than or equal to 5 mm (89% vs 95%, p = 0.004) and flat polyps (82% vs 94%, p = 0.001) especially benefited from 3D. Sensitivity was generally higher for polypoid than for flat polyps (99% vs 94%, p = 0.041). CONCLUSION Under phantom conditions, simulating an ideal clinical setup, MDCT colonography is not limited by spatial resolution and detects polyps less than or equal to 5 mm in size with high sensitivity and specificity. Additional 3D image tools improve diagnostic accuracy and reviewer confidence, especially for the detection of flat and small polyps.
Does corporate governance determine dividend payouts in Poland?

This study examines the relation between corporate governance practices measured by the Transparency Disclosure Index (TDI) and dividend payouts in Poland. Our empirical approach lies in constructing measures of the quality of the corporate governance in 110 non-financial companies listed on the Warsaw Stock Exchange between 1998 and 2004.We find evidence that an increase in the TDI or its sub-indices leads to an increase in the dividend to cash flow ratio. These results support the hypothesis that companies with weak shareholder rights pay dividends less generously than do firms with high corporate governance standards. We assume that well protected shareholders in Poland use their power to extract dividends, thus our results seem to support the outcome agency model of dividends.
The Cultural Politics of Ethnic Identity in Xishuangbanna, China: Tea and Rubber as “Cash Crops” and “Commodities”

In 2003, the poverty alleviation bureau in Xishuangbanna, China, introduced tea and rubber as cash crops to raise the incomes of ethnic-minority farmers who were thought to be backward and unfamiliar with markets. Using Marx's commodity fetish and Polly Hill's critique of “cash crops”, this paper analyses the cultural politics of ethnicity for Akha and Dai farmers in relation to tea and rubber. When the prefecture government introduces “cash crops”, the state retains its authority as the dispenser of knowledge, crops and modernity. When tea and rubber become commodities, however, some of the symbolic value of the commodity seems to stick to farmers, making rubber farmers “modern” and tea farmers “ethnic” in new ways. Through rising incomes and enhanced identities, Akha and Dai farmers unsettle stereotypes of themselves as “backward”. As a result of income levels matching those of urban middle-class residents, rubber farmers even challenge the prevalent social hierarchy.
Migration as the Second-best Option: Local Power and Off-farm Employment

In the 1980s and 1990s, China experienced rapid labour transfer from agricultural to non-agricultural activities. Large numbers of Chinese villagers sought to escape low-status and unprofitable work in grain cultivation through migration or local off-farm employment. Although migrants generally earned higher wage income, they suffered from inferior work and living conditions compared to local off-farm workers. All things considered, we argue that migration was a second best option for the villagers which they chose only after they had failed to secure comparable local employment. Under such circumstances, political power in the rural area was expected to have a significant influence on the outcome of local off-farm employment. When the off-farm population (migrants and local off-farm workers) is further divided into wage labourers and entrepreneurs, it can be seen that local power worked differently in each case. Being from a cadre family had little impact on whether a wage worker stayed local or migrated, but entrepreneurs with political connections were more likely to stay in the local area. This conclusion contradicts the “market transition” theory that asserts marketization (measured by the presence of private entrepreneurial activities) nullifies the advantage of traditional power. It also qualifies the “power persistence” theory in that positional power seemed less relevant for the wage labourers than for the private entrepreneurs.
Retinoic acid signalling centres in the avian embryo identified by sites of expression of synthesising and catabolising enzymes

Retinoic acid is an important signalling molecule in the developing embryo, but its precise distribution throughout development is very difficult to determine by available techniques. Examining the distribution of the enzymes by which it is synthesised by using in situ hybridisation is an alternative strategy. Here, we describe the distribution of three retinoic acid synthesising enzymes and one retinoic acid catabolic enzyme during the early stages of chick embryogenesis with the intention of identifying localized retinoic acid signalling regions. The enzymes involved are Raldh1, Raldh2, Raldh3, and Cyp26A1. Although some of these distributions have been described before, here we assemble them all in one species and several novel sites of enzyme expression are identified, including Hensen's node, the cardiac endoderm, the presumptive pancreatic endoderm, and the dorsal lens. This study emphasizes the dynamic pattern of expression of the enzymes that control the availability of retinoic acid as well as the role that retinoic acid plays in the development of many regions of the embryo throughout embryogenesis. This strategy provides a basis for understanding the phenotypes of retinoic acid teratology and retinoic acid–deficiency syndromes. Developmental Dynamics 227:114–127, 2003. © 2003 Wiley‐Liss, Inc.
Vascular access survival in children and young adults receiving long-term hemodialysis.

BACKGROUND The delivery of long-term hemodialysis therapy in children is complicated by smaller vascular caliber and the potential lifelong requirement for hemodialysis access. Various factors have resulted in the increased use of cuffed central venous catheters (CVLs) in preference to autologous arteriovenous fistulae (AVFs) and arteriovenous synthetic grafts (AVGs). The aim of this study is to compare CVL, AVF, and AVG survival and determine factors affecting their survival. METHODS A 20-year retrospective study was undertaken of pediatric patients receiving long-term hemodialysis therapy. Age, height, weight, body mass index, and sex were noted at each procedure, in addition to the presence of hypoalbuminemia, underlying diagnosis, type and site of vascular access, and effect of previous access surgery. The grade of operator also was noted. RESULTS Three hundred four vascular access procedures were performed on 114 patients, with a median age at initial access formation of 12.0 years (range, 4 weeks to 21.9 years). The most common procedure was CVL insertion (182 procedures) and then AVF formation (107 procedures), with only 15 AVGs created. Median censored survival was 3.14 years (95% confidence interval, 1.22 to 5.06) for AVFs and 0.6 years (95% confidence interval, 0.20 to 1.00) for CVLs. Factors adversely affecting vascular access survival were younger age, trainee operator, presence of hypoalbuminemia, and type of access undertaken, with AVF better than CVL. CONCLUSION This study shows increased survival of AVFs over CVLs and AVGs. Vascular access in children and adolescents may impact on future dialysis accessibility and should be undertaken by those most experienced in each technique.
A Declaration of the Independence of Cyberspace

Yesterday, that great invertebrate in the White House signed into the law the Telecom “Reform” Act of 1996, while Tipper Gore took digital photographs of the proceedings to be included in a book called “24 Hours in Cyberspace. ” I had also been asked to participate in the creation of this book by writing something appropriate to the moment. Given the atrocity that this legislation would seek to inflict on the Net, I decided it was as good a time as any to dump some tea in the virtual harbor. After all, the Telecom “Reform” Act, passed in the Senate with only 5 dissenting votes, makes it unlawful, and punishable by a $250,000 to say “shit” online. Or, for that matter, to say any of the other 7 dirty words prohibited in broadcast media. Or to discuss abortion openly. Or to talk about any bodily function in any but the most clinical terms. It attempts to place more restrictive constraints on the conversation in Cyberspace than presently exist in the Senate cafeteria, where I have dined and heard colorful indecencies spoken by United States senators on every occasion I did. This bill was enacted upon us by people who haven’t the slightest idea who we are or where our conversation is being conducted. It is, as my good friend and Wired Editor Louis Rossetto put it, as though “the illiterate could tell you what to read. ” Well, fuck them. Or, more to the point, let us now take our leave of them. They have declared war on Cyberspace. Let us show them how cunning, baffling, and powerful we can be in our own defense. I have written something (with characteristic grandiosity) that I hope will become one of many means to this end. If you find it useful, I hope you will pass it on as widely as possible. You can leave my name off it if you like, because I don’t care about the credit. I really don’t. But I do hope this cry will echo across Cyberspace, changing and growing and self-replicating, until it becomes a great shout equal to the idiocy they have just inflicted upon us. I give you. A Declaration of the Independence of Cyberspace
Modelling regional labour market dynamics in space and time

type="main" xml:lang="es"> Este articulo amplia el modelo seminal de mercado laboral regional de Blanchard y Katz con la inclusion de efectos de interaccion por medio de un enfoque de datos de panel espacial dinamico. Son tres las contribuciones clave de este modelo ampliado: (i) la suposicion poco realista de que las regiones son independientes entre si ya no es necesaria; (ii) la magnitud y la importancia de los llamados efectos de spillover se pueden evaluar empiricamente; y (iii) se puede investigar las propagaciones temporal y espacial de perturbaciones en la demanda de mano de obra. Por medio de datos anuales del periodo 1986–2010 para 112 regiones en ocho paises de la UE, se han estimado tanto los modelos no espaciales como los espaciales. Se encontro que la mayoria de los efectos de spillover son altamente significativos. De acuerdo con la teoria economica, el impacto de una perturbacion de la demanda especifica para una region es mas grande en la region en la que se origina la perturbacion. La perturbacion tambien se propaga a otras regiones, afectando especialmente a los vecinos de primer y segundo orden.
Human Resource Information Systems (HRIS): Providing Business with Rapid Data Access, Information Exchange and Strategic Advantage

This article will review the major components of a Human Resource Information System (HRIS), including systems that are computerized and those that are not. These basic components provide a foundation for the reader to understand and explore how computerized and non-computerized information can assist human resources (HR) professionals achieve certain human resource objectives. There are many different types of computer software available to help in developing a comprehensive human resource information system. There is no doubt that personal computers can support real human resource decisions, but the information must be available in a form that can be utilized effectively in the decision making process.
Is southwestern China experiencing more frequent precipitation extremes?

Climate extremes have and will continue to cause severe damages to buildings and natural environments around the world. A full knowledge of the probability of the climate extremes is important for the management and mitigation of natural hazards. Based on Mann–Kendall trend test and copulas, this study investigated the characteristics of precipitation extremes as well as their implications in southwestern China (Yunnan, Guangxi and Guizhou Province), through analyzing the changing trends and probabilistic characteristics of six indices, including the consecutive dry days, consecutive wet days, annual total wet day precipitation, heavy precipitation days (R25), max 5 day precipitation amount (Rx5) and the rainy days (RDs). Results showed that the study area had generally become drier (regional mean annual precipitation decreased by 11.4 mm per decade) and experienced enhanced precipitation extremes in the past 60 years. Relatively higher risk of drought in Yuanan and flood in Guangxi was observed, respectively. However, the changing trends of the precipitation extremes were not spatially uniform: increasing risk of extreme wet events for Guangxi and Guizhou, and increasing probability of concurrent extreme wet and dry events for Yunnan. Meanwhile, trend analyses of the 10 year return levels of the selected indices implied that the severity of droughts decreased in Yunnan but increased significantly in Guangxi and Guizhou, and the severity of floods increased in Yunnan and Guangxi in the past decades. Hence, the policy-makers need to be aware of the different characterizations and the spatial heterogeneity of the precipitation extremes.
Income Poverty and Material Hardship: How Strong is the Association?

Material deprivation has been measured in a variety of ways, such as in terms of income shortfalls or the experience of different types of material hardship. This paper tests the extent to which indicators of hardship are associated with income poverty. Using a U.S. dataset with detailed income and poverty information observed over a few years, we find that timing, duration, and depth of poverty are all associated with material hardships (food insecurity, difficulty meeting basic needs, lack of consumer durables, housing problems, neighborhood problems, and fear of crime). Even very short spells of poverty have a measurable impact on material well-being, although not all types of well-being are affected in equal measures.
Exchange Rate Regimes and International Trade

The existing evidence on the volume effects of exchange rate risk and exchange rate regime choice is examined. The analysis involves estimating the effects of cross-country differences in exchange rate regime on export and import elasticities using a continuous measure of the degree of exchange rate flexibility. It is argued that risk for firms involved in international trade tends to decrease with greater exchange rate flexibility. In formulating our hypotheses we argued that the cross-country variation in U.S. export elasticities with respect to the real exchange rate and foreign GDPs is primarily attributable to the cross- country variation in bilateral exchange rate regime-related risk. The empirical results showed that U.S. export elasticities increase with the degree of bilateral exchange rate flexibility of the importing country. We interpreted this result as an indication that the total macroeconomic risk exporters face decreases as the degree of exchange rate flexibility increases.
An Empirical Window on Rational Expectations Formation

Persons' expectations regarding their ultimate life span provide a tractable empirical opportunity to test for rational expectations. To the extent people only utilize information from "current life tables," they underestimate the more relevant ultimate life expectancy that results from on-going improvements in mortality experience not reflected in these tables. The expectations observed in the authors' empirical work are not consistent with rational-expectations models. All available information about life expectancies and their trends were not used by the surveyed households in forming life-span expectations. This deficiency precludes correct estimation of the ultimate life expectancy necessary for informed life-cycle choices. Copyright 1992 by MIT Press.
Remission of Seizures and Predictors of Intractability in Long‐Term Follow‐Up

In an incidence cohort, remission and relapse rates and determinants were studied in 178 patients followed long‐term. A comparative study of predictive factors was performed in 40 patients with histories of antiepileptic (AED)‐drug‐refractory epileptic seizures in the last 10 years of follow‐up and compared with the other 138 cohort subjects. The two groups were cross‐tabulated with 353 variables of family history, obstetric, developmental and seizure histories, and current medical and social status. Multivariate analyses were applied for control of confounding. Defined or probable remote symptomatic etiology of seizures, abnormal neurologic development/ status, high initial seizure frequency, occurrence of status epilepticus, and poor short‐term effects of AED therapy were significantly associated with long‐term AED refractoriness. On logistic regression analyses, poor short‐term outcome of AED therapy [odds ratio (OR) 3.6; 95% confidence interval (CI) 1.2–10.4], occurrence of status epilepticus (OR 11.4; 95% CI 3.2–41.0), high initial seizure frequency (OR 4.6; 95% CI 1.1–19.3), and remote symptomatic seizure etiology (OR 2.9; 95% CI 1.1–8.2) remained the only independent predictors of seizure intractability. These factors enable early assessment of need for epilepsy surgery.
Defence spending and economic growth in South Africa: A supply and demand model

This paper provides a contribution to the growing corpus of knowledge and understanding of the interaction between economic growth and defence spending in South Africa by specifying a Keynesian simultaneous equation model and estimating the system for the period 1961 to 1997. The model contains a growth equation, a savings equation, a trade balance equation and a military burden equation and when estimated by single equation and systems estimation methods is relatively well specified. There is evidence of an overall negative effect of military spending on the economy over this period, though the significance of individual coefficients is low. There is certainly no evidence of any positive impact, suggesting that cuts in military spending do present an opportunity for improved macroeconomic performance.