Miracle-dz/UniFAR-FTUs huggingface dataset:
Charging Model Research of Infrastructure Layer in Cloud Computing Based on Cost-Profit Petri Net

Cloud computing is a rising IT industry. How to charge for cloud computing is an important problem to be solved urgently at present. By analyzing and sorting, this article designs a charging model based on infrastructure layer in cloud computing called the infrastructure cloud. This article also proposes a Petri net which introduces costs and profits. A problem that attracts common concern in industrial circles. Based on the cost-profit Petri net, this article contributes to modeling design and analysis about charging model in cloud computing infrastructure layer.
Comparison of Platforms for Testing Antibody Responses against the Chlamydia trachomatis Antigen Pgp3

Abstract. Antibody responses to Chlamydia trachomatis (CT) antigens may be useful tools for surveillance of trachoma by estimating cumulative prevalence of infection within a population. Data were compared from three different platforms—multiplex bead array (MBA), enzyme-linked immunosorbent assay (ELISA), and lateral flow assay (LFA)—measuring antibody responses against the CT antigen protein plasmid gene product 3 (Pgp3). Sensitivity was defined as the proportion of specimens testing antibody positive from a set of dried blood spots from Tanzanian 1–9-year olds who were positive for CT nucleic acid of all nucleic acid amplification test (NAAT)-positive individuals (N = 103). The sensitivity of the LFA could not be determined because of the use of dried blood spots for this test; this specimen type has yet to be adapted to LFA. Specificity was defined as the proportion of sera from U.S. and Bolivian 1–9-year olds that had previously tested negative by the Chlamydia microimmunofluorescence (MIF) assay testing negative to Pgp3-specific antibodies (N = 154). The sensitivity for MBA and ELISA was the same—93.2 (95% confidence interval [CI]: 88.3–98.1). Specificity ranged across platforms from 96.1 (95% CI: 91.8–98.2) to 99.4% (95% CI: 98.2–100). ELISA performance was similar regardless of whether the plates were precoated or freshly coated with antigen. Sensitivity and specificity of control panels were similar if the cutoff was determined using receiver operator curves or a finite mixture model, but the cutoffs themselves differed by approximately 0.5 OD using the different methodologies. These platforms show good sensitivity and specificity and show good agreement between tests at a population level, but indicate variability for ELISA outcomes depending on the cutoff determination methodology.
Typechecking Polymorphism in Emerald

Emerald is a statically typed object-oriented language that was originally intended for programming distributed subsystems and applications [Jul 88]. It is important that such systems be dynamically extensible, i.e., that it be possible to introduce new kinds of entities into the system without re-compiling or re-linking the whole system. This led us to devise a type system based on the notion of type conformity rather than type equality. We also felt that polymorphism was a necessary feature of a modern programming language: programmers should be able to de ne generic abstractions like homogeneous sets, lists and les into which objects of arbitrary type can be placed. The combination of object-orientation, type-checking based on conformity and polymorphism gave rise to some interesting problems when designing Emerald's type system. This paper describes the Emerald's type-checking mechanism and the notion of types and parameterization on which it is based.
Adolescent Self-Organization and Adult Smoking and Drinking over Fifty Years of Follow-Up: The British 1946 Birth Cohort

Variations in markers of adolescent self-organization predict a range of economic and health-related outcomes in general population studies. Using a population-based birth cohort study we investigated associations between adolescent self-organization and two common factors over adulthood influencing health, smoking and alcohol consumption. The MRC National Survey of Health and Development (the British 1946 birth cohort) was used to test associations between a dimensional measure of adolescent self-organization derived from teacher ratings, and summary longitudinal measures of smoking and alcohol consumption over the ensuing five decades. Multinomial regression models were adjusted for sex, adolescent emotional and conduct problems, occupational social class of origin, childhood cognition, educational attainment and adult occupational social class. With all covariates adjusted, higher adolescent self-organization was associated with fewer smoking pack years, although not with quitting; there was no association with alcohol consumption across adulthood (none or heavy compared with light to moderate). Adolescent self-organization appears to be protective against smoking, but not against heavy alcohol consumption. Interpretation of this differential effect should be embedded in an understanding of the social and sociodemographic context in which these health behaviours occur over time.
Megaprosthesis of the knee in tumor and revision surgery

The introduction of multidisciplinary approach with chemo and radiotherapy, the advances in surgical and the improvements of diagnostic techniques allowed limb salvage surgery in most cases of bone sarcomas instead of amputation. Modular megaprostheses are the most common method of reconstruction after segmental resection of the long bones in the extremities for their availability, immediate fixation, early weight bearing, good function. Despite the advances in materials and implant designs, these systems have an high incidence of complications. Aim of this study was to report the experience on mega-prostheses implanted around the knee in tumor and revision surgery to analyze: the most frequent used current systems, the problems of stems fixation, extensor mechanism reconstructions in proximal tibia resections and the preservation of growth of the lower extremity in children. (www.actabiomedica.it)
Revision of the troponin T release mechanism from damaged human myocardium.

BACKGROUND Cardiac troponin T (cTnT) is released from damaged heart tissue in patients with acute myocardial infarction. It is presumed that most cTnT is tightly bound and released following the degradation of myofibrils in necrotic cardiomyocytes, resulting in sustained increases in circulating cTnT. Evidence of a large irreversibly bound fraction is based on the inability to extract most cTnT from cardiac tissue in cold low-salt extraction buffers. METHODS Here we examined in vitro extraction of cTnT from human cardiac tissue in serum at 37 °C. RESULTS We found that over 80% of the cTnT can be extracted from human cardiac tissue in 90 min using large volumes of human serum at 37 °C. The release ratio was highly dependent on the extraction volume and was only 3% if an equal volume of serum and heart tissue was used. In contrast, extraction of the cytoplasmic cardiac damage markers myoglobin and creatinine kinase was much less affected by changing these conditions. Purified cTnT was poorly soluble in a low-salt extraction buffer at 0 °C, previously used to define the free cTnT fraction. CONCLUSIONS Our data indicate that the diffusible fraction of cTnT is likely substantially larger in vivo than previously reported and likely is not fixed but dependent on local plasma flow. It is therefore possible that the sustained increase in circulating cTnT after myocardial infarction is at least in part due to a slow washout of cTnT that interacts reversibly with tropomyosin in myofibrils.
A uniform CO survey of the molecular clouds in Orion and Monoceros

We report the results of a new large scale survey of the Orion-Monoceros complex of molecular clouds made in the J = 1 → 0 line of 12 CO with the Harvard-Smithsonian 1.2 m millimetre-wave telescope. The survey consists of 52 288 uniformly spaced spectra that cover an area of 432 deg 2 on the sky and represent the most sensitive large-scale survey of the region to date. Distances to the constituent molecular clouds of the complex, estimated from an analysis of foreground and background stars, have provided information on the three dimensional structure of the entire complex.
A new single-error correction scheme based on self-diagnosis residue number arithmetic

With the rapid size shrinking in electronic devices, radiation-induced soft-error has emerged as a major concern to the current circuit manufacturing. In this paper, we present a new error correction scheme based on the residue number arithmetic to cope with the single soft-error issue. The proposed technique called bidirectional redundant residue number system requires the redundant moduli to satisfy some constraints to achieve fast error correction. In this system, both the iterations for decoding the valid number and the error-correcting table that contains all combinations of erroneous digit, are not necessary. The detection and the diagnosis are simultaneously performed in plural parallel consistent-checking that has the capability of locating the corrupt digit. Finally, efficient pipeline architecture for the self-diagnosis decoder is detailed.
An asymptotic theory of topographic feedback on the beta-drift of a surface-intensified vortex

The propagation of compact, surface-intensified vortices on the β-plane is studied in the framework of a two-layer model with sloping topography. A perturbation theory is derived for a circular vortex in the upper layer with the lower layer at rest as a basic state. An integral momentum balance for the upper layer is used to obtain expressions for the velocity of the vortex center assuming the interface is described by a circular dome in the leading order. This approach allows us to reduce the problem to the calculation of the deep-flow pattern, depending on the interface shape and bottom friction. The most essential part of the deep-flow pattern are elongated dipolar gyres generated by the cross-slope β-drift. Corresponding deep-flow feedback provides an additional along-slope propagation which is proportional to the crossslope drift speed, and to the ratio of the interface slope to the topographic slope. Over a steep topographic slope, when the lower layer depth contours are open, the deep flow approaches the inviscid solution in the limit of small friction. On the other hand, in the case of a gentle topographic slope, the inviscid limit does not exist on a certain set of closed contours of the lower layer thickness field, lying beneath the dome. In this case, the deep-flow pattern becomes strongly asymmetric and frictionally controlled; the dominant deep-flow circulation and corresponding coefficient of the deep-flow feedback are then inversely proportional to the friction coefficient.
What determines the switch between atrophic and neovascular forms of age related macular degeneration? - the role of BMP4 induced senescence

Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, targets the retinal pigment epithelium (RPE), a monolayer of cells at the back of the eye. As AMD progresses, it can develop into two distinct forms of late AMD: "dry," atrophic AMD, characterized by RPE senescence and geographic RPE loss, and "wet," neovascular AMD, characterized by RPE activation with abnormal growth of choroidal vessels. The genetic and molecular pathways that lead to these diverse phenotypes are currently under investigation. We have found that bone morphogenetic protein-4 (BMP4) is differentially expressed in atrophic and neovascular AMD. In atrophic AMD, BMP4 is highly expressed in RPE, and mediates oxidative stress induced RPE senescencein vitro via Smad and p38 pathways. In contrast, in neovascular AMD lesions, BMP4 expression in RPE is low, possibly a result of local expression of pro-inflammatory mediators. Thus, BMP4 may be involved in the molecular switch determining which phenotypic pathway is taken in the progression of AMD.
Throughput Analysis of Wireless Multi-hop Chain Networks

It is important but challenging to understand the throughput performance in wireless multi-hop networks. Most previous works show that the M/M/1 model is accurate enough for throughput analysis most of the time. However, we notice that without considering the interrelationship between the traffic on nodes, the M/M/1 model is quite inaccurate sometimes, especially on the typical chain topology. Therefore in this paper, we propose a model called Traffic-Analysis-Based (TAB) for throughput analysis focusing on chains. TAB obtains the throughput by analyzing the state transition process of the chain as the traffic rate is increasing, based on the traffic interrelationships. Besides the throughput of each node, we also get two significant state transition points. One is the optimal sending rate of traffic, and the other is the lower bound when M/M/1 can be used. Simulation results show that TAB is much more accurate than M/M/1 when the traffic rate is under the second transition point.
The Constraints Functional Neuroimaging Places on Classical Models of Auditory Word Processing

Several previous functional imaging experiments have demonstrated that auditory presentation of speech, relative to tones or scrambled speech, activate the superior temporal sulci (STS) bilaterally. In this study, we attempted to segregate the neural responses to phonological, lexical, and semantic input by contrasting activation elicited by heard words, meaningless syllables, and environmental sounds. Inevitable differences between the duration and amplitude of each stimulus type were controlled with auditory noise bursts matched to each activation stimulus. Half the subjects were instructed to say okay in response to presentation of all stimuli. The other half repeated back the words and syllables, named the source of the sounds, and said okay to the control stimuli (noise bursts). We looked for stimulus effects that were consistent across task. The results revealed that central regions in the STS were equally responsive to speech (words and syllables) and familiar sounds, whereas the posterior and anterior regions of the left superior temporal gyrus were more active for speech. The effect of semantic input was small but revealed more activation in the inferior temporal cortex for words and familiar sounds than syllables and noise. In addition, words (relative to syllables, sounds, and noise) enhanced activation in the temporo-parietal areas that have previously been linked to modality independent semantic processing. Thus, in cognitive terms, we dissociate phono-logical (speech) and semantic responses and propose that word specificity arises from functional integration among shared phonological and semantic areas.
Adiposity and Blood Pressure in 110 000 Mexican Adults

Previous studies have reached differing conclusions about the importance of general versus central markers of adiposity to blood pressure, leading to suggestions that population-specific adiposity thresholds may be needed. We examined the relevance of adiposity to blood pressure among 111 911 men and women who, when recruited into the Mexico City Prospective Study, were aged 35 to 89 years, had no chronic disease, and were not taking antihypertensives. Linear regression was used to estimate the effects on systolic and diastolic blood pressure of 2 markers of general adiposity (body mass index and height-adjusted weight) and 4 markers of central adiposity (waist circumference, hip circumference, waist:hip ratio, and waist:height ratio), adjusted for relevant confounders. Mean (SD) adiposity levels were: body mass index (28.7±4.5 kg/m2), height-adjusted weight (70.2±11.2 kg), waist circumference (93.3±10.6 cm), hip circumference (104.0±9.0 cm), waist:hip ratio (0.90±0.06), and waist:height ratio (0.60±0.07). Associations with blood pressure were linear with no threshold levels below which lower general or central adiposity was not associated with lower blood pressure. On average, each 1 SD higher measured adiposity marker was associated with a 3 mm Hg higher systolic blood pressure and 2 mm Hg higher diastolic blood pressure (SEs <0.1 mm Hg), but for the waist:hip ratio, associations were only approximately half as strong. General adiposity associations were independent of central adiposity, but central adiposity associations were substantially reduced by adjustment for general adiposity. Findings were similar for men and women. In Mexican adults, often overweight or obese, markers of general adiposity were stronger independent predictors of blood pressure than measured markers of central adiposity, with no threshold effects.
Assessing the Lucas Critique in Monetary Policy Models

Empirical estimates of monetary policy rules suggest that the behavior of U.S. monetary policymakers changed during the past few decades. However, for that same time period, statistical analyses of lagged representations of the economy, such as VARs, often have not rejected the null of structural stability. These two sets of empirical results appear to contradict the Lucas critique. This paper reconciles these results with the Lucas critique by showing that the apparent policy invariance of reduced forms is consistent with the magnitude of historical policy shifts and the relative insensitivity of the reduced forms of plausible forward-looking macroeconomic specifications to policy shifts.
Incomplete Depletion and Rapid Regeneration of Foxp3+ Regulatory T Cells Following Anti-CD25 Treatment in Malaria-Infected Mice1

Investigation of the role of regulatory T cells (Treg) in model systems is facilitated by their depletion using anti-CD25 Abs, but there has been considerable debate about the effectiveness of this strategy. In this study, we have compared the depletion and repopulation of CD4+CD25+Foxp3+ Treg in uninfected and malaria-infected mice using 7D4 and/or PC61 anti-CD25 Abs. We find that numbers and percentages of CD25high cells, but not Foxp3+ cells, are transiently reduced after 7D4 treatment, whereas treatment with PC61 alone or in combination with 7D4 (7D4 plus PC61) reduces but does not eliminate Foxp3+ cells for up to 2 wk. Importantly, all protocols fail to eliminate significant populations of CD25−Foxp3+ or CD25lowFoxp3+ cells, which retain potent regulatory capacity. By adoptive transfer we show that repopulation of the spleen by CD25highFoxp3+ cells results from the re-expression of CD25 on peripheral populations of CD25−Foxp3+ but not from the conversion of peripheral Foxp3− cells. CD25highFoxp3+ repopulation occurs more rapidly in 7D4-treated mice than in 7D4 plus PC61-treated mice, reflecting ongoing clearance of emergent CD25+Foxp3+ cells by persistent PC61 Ab. However, in 7D4 plus PC61-treated mice undergoing acute malaria infection, repopulation of the spleen by CD25+Foxp3+ cells occurs extremely rapidly, with malaria infection driving proliferation and CD25 expression in peripheral CD4+CD25−Foxp3+ cells and/or conversion of CD4+CD25−Foxp3− cells. Finally, we reveal an essential role for IL-2 for the re-expression of CD25 by Foxp3+ cells after anti-CD25 treatment and observe that TGF-β is required, in the absence of CD25 and IL-2, to maintain splenic Foxp3+ cell numbers and a normal ratio of Treg:non-Treg cells.
Respiratory syncytial virus infection and disease in infants and young children observed from birth in Kilifi District, Kenya.

BACKGROUND In developing countries, there are few data that characterize the disease burden attributable to respiratory syncytial virus (RSV) and clearly define which age group to target for vaccine intervention. METHODS Six hundred thirty-five children, recruited during the period 2002-2003, were intensively monitored until each experienced 3 epidemics of RSV infection. RSV infection was diagnosed using immunofluorescence of nasal washing specimens collected at each episode of acute respiratory infection. Incidence estimates were adjusted for seasonality of RSV exposure. RESULTS For 1187 child-years of observation (CYO), a total of 409 (365 primary and 82 repeat) episodes of RSV infection were identified. Adjusted incidence estimates of lower respiratory tract infection (LRTI), severe LRTI, and hospital admission were 90 cases per 1000 CYO, 43 cases per 1000 CYO, and 10 cases per 1000 CYO, respectively, and corresponding estimates among infants were 104 cases per 1000 CYO, 66 cases per 1000 CYO, and 13 cases per 1000 CYO, respectively. The proportion of cases of all-cause LRTI, and severe LRTI and hospitalizations attributable to RSV in the cohort was 13%, 19%, and 5%, respectively. Fifty-five percent to 65% of RSV-associated LRTI and severe LRTI occurred in children aged >6 months. The risk of RSV disease following primary symptomatic infection remained significant beyond the first year of life, and one-quarter of all reinfections were associated with LRTI. CONCLUSIONS RSV accounts for a substantial proportion of the total respiratory disease in this rural population; we estimate that 85,000 cases of severe LRTI per year occur in infants in Kenya. The majority of this morbidity occurs during late infancy and early childhood--ages at which the risk of disease following infection remains significant. Disease resulting from reinfection is common. Our results inform the debate on the target age group and effectiveness of a vaccine.
The Modular Group Action on Real SL(2)-characters of a One-Holed Torus

The group Gamma of automorphisms of the polynomial kappa(x,y,z) = x^2 + y^2 + z^2 - xyz -2 is isomorphic to PGL(2,Z) semi-direct product with (Z/2+Z/2). For t in R, Gamma-action on ktR = kappa^{-1}(t) intersect R displays rich and varied dynamics. The action of Gamma preserves a Poisson structure defining a Gamma-invariant area form on each ktR. For t 18, in which case the Gamma-action on the complement ktR - Omega is ergodic.
Impulsive choice in hippocampal but not orbitofrontal cortex-lesioned rats on a nonspatial decision-making maze task

Orbitofrontal cortical (OFC) and hippocampal (HPC) lesions in primates and rodents have been associated with impulsive behaviour. We showed previously that OFC‐ or HPC‐lesioned rats chose the immediate low‐reward (LR) option in preference to the delayed high‐reward (HR) option, where LR and HR were associated with different spatial responses in a uniform grey T‐maze. We now report that on a novel nonspatial T‐maze task in which the HR and LR options are associated with patterned goal arms (black‐and‐white stripes vs. gray), OFC‐lesioned rats did not show impulsive behaviour, choosing the delayed HR option, and were indistinguishable from controls. In contrast, HPC‐lesioned rats exhibited impulsive choice in the nonspatial decision‐making task, although they chose the HR option on the majority of trials when there was a 10‐s delay associated with both goal arms. The previously reported impairment in OFC‐lesioned rats on the spatial version of the intertemporal choice task is unlikely to reflect a general problem with spatial learning, because OFC lesions were without effect on acquisition of the standard reference memory water‐maze task and spatial working memory performance (nonmatching‐to‐place) on the T‐maze. The differential effect of OFC lesions on the two versions of the intertemporal choice task may be explained instead in terms of the putative role of OFC in using associative information to represent expected outcomes and generate predictions. The impulsivity in HPC‐lesioned rats may reflect impaired temporal information processing, and emphasizes a role for the hippocampus beyond the spatial domain.