Miracle-dz/UniFAR-FTUs huggingface dataset:
Combined VSV Oncolytic Virus and Chemotherapy for Squamous Cell Carcinoma

Objectives: Vesicular stomatitis virus (VSV) is a negative‐strand ribonucleic acid (RNA) virus that replicates specifically in tumor cells and has oncolytic effects in a variety of malignant tumors. We previously demonstrated recombinant VSV vectors incorporating viral fusion protein (rVSV‐F) and interleukin 12 (rVSV‐IL12) to have significant antitumor effects against squamous cell carcinoma (SCC) in a murine model. Here we evaluate the potential to combine a potent chemotherapeutic agent for SCC (cisplatin) with rVSV‐F and rVSV‐IL12 to improve efficacy.
Effect of dietary protein source on feed intake, growth, pancreatic enzyme activities and jejunal morphology in newly-weaned piglets

Seventy piglets with no access to creep feed were weaned at 28 d of age and fed on one of four diets based on either skimmed-milk powder (SMP), soya-bean-protein concentrate (SPC), soya-bean meal (SBM) or fish meal (FM). At 0, 3, 6 and 10 d after weaning, piglets were killed and the pancreas and digesta from stomach and small intestine were collected, freeze-dried and analysed for dry matter (DM), N, and trypsin (EC3.4.21.4) and chymotrypsin (EC3.4.21.1) activities. Small-intestinal tissue samples were taken to examine gut wall morphology. Results indicated that dietary protein source affected post-weaning feed intake, pancreatic weight, gastric pH and gastric protein breakdown, and pancreatic and jejunal trypsin and chymotrypsin activities. Post-weaning feed intake appeared to be an important factor in digestive development of newly-weaned piglets.
Patient Beliefs Have a Greater Impact Than Barriers on Medication Adherence in a Community Health Center

Purpose: Nonadherence to medicines contributes to poor health outcomes, especially for patients with complicated medicine regimens. We examined adherence among patients at a family health center and the impact that barriers to getting medicines and negative beliefs about medicines have on adherence. Methods: A survey was administered incorporating the 8-item Morisky Medication Adherence Scale, questions from the Beliefs about Medicine Questionnaire, and questions about patients' external barriers to getting medicines. Low adherence was examined by any external barrier and by higher negative beliefs, adjusting for patient characteristics. Results: The convenience sample of 343 participants is demographically representative of the larger population. Among these patients, 54% report low adherence, 51% have at least 1 barrier to adherence, and 52% report more negative than positive beliefs about medicines. When beliefs and barriers are examined together, patients with negative beliefs are 49% less likely to adhere than those with more positive beliefs, whereas barriers show no significant impact on adherence. Conclusions: Negative beliefs about medicines are as prevalent in this population as external barriers to accessing medicines, but negative beliefs were more significantly associated with adherence than external barriers. Physicians should identify and address patients' negative beliefs about medicines to improve adherence rates.
Relationship between Narrow-Band Imaging Magnifying Observation and Pit Pattern Diagnosis in Colorectal Tumors

Background/Aim: The aim of this study was to examine the relationship between narrow-band imaging (NBI) magnifying observation using the surface pattern as the main evaluation criterion and pit pattern diagnosis on the basis of magnifying observation using a dye in relation to the characteristics of colorectal tumors according to their morphologies. Methods: In this study, NBI observation and pit pattern diagnosis using a dye with magnifying observation were simultaneously performed in our hospital, and the consecutive 786 cases of colorectal lesions (hyperplasia, adenomata and early carcinomas) that had been endoscopically or surgically resected were retrospectively analyzed. NBI magnifying observation was in conformance with the Hiroshima classification and pit pattern diagnosis was in conformance with the Kudo and Tsuruta classification. The relationship between NBI magnifying observation and pit pattern diagnosis and that between NBI magnifying observation and the histological type/invasion depth were examined in relation to colorectal tumor morphology. Results: Type A corresponded to the type II pit pattern, type B corresponded to the type IIIS, type IIIL and type IV regular pit patterns, type C1 corresponded to the type VI slightly irregular pit pattern, type C2 corresponded to the type VI highly irregular pit pattern and type C3 corresponded to the type VN pit pattern. In the protruded type, the irregularity of type C1 or C2 lesions agreed with the type VI slightly or highly irregular pit pattern, respectively, in 114 cases (64.0%). Moreover, the irregularity was higher with NBI magnifying observation than with pit pattern diagnosis in 58 cases (32.6%). In the superficial type, the irregularity of type C1 or C2 lesions agreed with the type VI slightly or highly irregular pit pattern, respectively, in 63 cases (71.6%). Moreover, the irregularity was higher with NBI magnifying observation than with pit pattern diagnosis in 19 cases (21.6%). In the case of type C1 or C2 lesions, the irregularity tended to be higher with NBI magnifying observation than with pit pattern diagnosis in the protruded type compared to the superficial type (p = 0.087). Conclusion: The surface pattern, which was visible in NBI magnifying observation, differed from the pit pattern findings obtained by magnifying endoscopic observation using a dye. Findings were more detailed in pit pattern diagnosis using a dye than in NBI magnifying observation.
Lake sediments record large-scale shifts in moisture regimes across the northern prairies of North America during the past two millennia

Six high-resolution climatic reconstructions, based on diatom analyses from lake sediment cores from the northern prairies of North America, show that shifts in drought conditions on decadal through multicentennial scales have prevailed in this region for at least the last two millennia. The predominant broad-scale pattern seen at all sites is a major shift in moisture regimes from wet to dry, or vice versa (depending on location), that occurred after a period of relative stability. These large-scale shifts at the different sites exhibit spatial coherence at regional scales. The three Canadian sites record this abrupt shift between anno Domini 500 and 800, and subsequently conditions become increasingly variable. All three U.S. sites underwent a pronounced change, but the timing of this change is between anno Domini 1000 and 1300, thus later than in all of the Canadian sites. The mechanisms behind these patterns are poorly understood, but they are likely related to changes in the shape and location of the jet stream and associated storm tracks. If the patterns seen at these sites are representative of the region, this observed pattern can have huge implications for future water availability in this region.
American Journal of Psychological Research the Phonological Loop and Articulatory Suppression

The researchers designed this study to demonstrate the role played by the phonological loop as defined by Baddeley's model of working memory (2000). The operation of the phonological loop can be disrupted by oral repetition of sounds while attempting to utilize working memory, a task known as articulatory suppression. The study utilized a between-group, experimental design to demonstrate the effectiveness of articulatory suppression for reducing accuracy of serial recall of a visually presented list of phonologically dissimilar letters.
A Mention-Ranking Model for Abstract Anaphora Resolution

Resolving abstract anaphora is an important, but difficult task for text understanding. Yet, with recent advances in representation learning this task becomes a more tangible aim. A central property of abstract anaphora is that it establishes a relation between the anaphor embedded in the anaphoric sentence and its (typically non-nominal) antecedent. We propose a mention-ranking model that learns how abstract anaphors relate to their antecedents with an LSTM-Siamese Net. We overcome the lack of training data by generating artificial anaphoric sentence–antecedent pairs. Our model outperforms state-of-the-art results on shell noun resolution. We also report first benchmark results on an abstract anaphora subset of the ARRAU corpus. This corpus presents a greater challenge due to a mixture of nominal and pronominal anaphors and a greater range of confounders. We found model variants that outperform the baselines for nominal anaphors, without training on individual anaphor data, but still lag behind for pronominal anaphors. Our model selects syntactically plausible candidates and – if disregarding syntax – discriminates candidates using deeper features.
Does stent strut design impact clinical outcomes: comparative safety and efficacy of Endeavor Resolute versus Resolute Integrity zotarolimus-eluting stents.

UNLABELLED Percutaneous coronary intervention is the most commonly performed method of revascularizing obstructive coronary artery disease. The impact of stent strut design on clinical outcomes remains unclear. The Endeavour Resolute (ER-ZES) and the Resolute Integrity (RI-ZES) zotarolimus-eluting stents utilize identical polymers and anti-proliferative agents, differing only in their respective strut design. This study assessed the comparative safety and efficacy of these two stents in unrestricted contemporary real-world practice. METHODS A total of 542 patients were identified, corresponding to 340 ER-ZES and 480 RI-ZES. The primary endpoint was major adverse cardiac events (MACE) defined by a composite of death, nonfatal myocardial infarction and stroke. Secondary endpoints included post-procedural length of stay, in-stent restenosis, target lesion revascularization, target vessel revascularization, coronary artery bypass grafting and stent thrombosis. RESULTS MACE occurred in 3.2% of the ER-ZES cohort and 5.0% of the RI-ZES cohort (p= 0.43). Adjusted analysis utilizing propensity score-adjusted odds ratio for MACE, was 1.37 (95% CI 0.46-4.07, p=0.57). The mortality rate (0.9% ER-ZES vs. 1.9% RI-ZES, p=0.59), non-fatal MI (2.3% ER-ZES vs. 3.1% RI-ZES, p=0.75) and stroke (0.0% ER-ZES vs. 0.3% RI-ZES, p=0.85) were not different. Additionally, there was no difference in any of secondary outcomes. CONCLUSIONS The clinical performance and safety of both ER-ZES and RI-ZES were not statistically different, despite differences in stent strut design.
3 D ZEBRA-CROSSING RECONSTRUCTION FROM STEREO RIG IMAGES OF A GROUND-BASED MOBILE MAPPING SYSTEM 1

: Zebra-crossings are very speciﬁc road features that are less generalized when imaged at different scales. We aim to use zebra-crossings as control objects for georeferencing the images provided by a Mobile Mapping System (MMS) using the oriented aerial images of the same area. In this paper, we present a full automatic method for 3D zebra-crossing reconstruction from our MMS calibrated stereo rig. In our image-based georeferencing context, reconstruction accuracy is a priority. The only assumption made is that each zebra-crossing band is supposed to be planar and to have an a priori known 3D width. The method consists in reconstructing the 3D edges using a sub-pixel edge matching process by dynamic programming. The detection step is run on all 3D edges around the estimated road plane by looking for parallel segment lines with speciﬁc distances. The accurate 3D plane of each band is then estimated from the points belonging to the two previously detected sides. The short sides of each band are detected on the image and are projected onto the 3D plane of the band. Our method is robust and provides promising results. We have a good geometric accuracy.
User authentication through typing biometrics features

This paper uses a static keystroke dynamics in user authentication. The inputs are the key down and up times and the key ASCII codes captured while the user is typing a string. Four features (key code, two keystroke latencies, and key duration) were analyzed and seven experiments were performed combining these features. The results of the experiments were evaluated with three types of user: the legitimate, the impostor and the observer impostor users. The best results were achieved utilizing all features, obtaining a false rejection rate of 1.45% and a false acceptance rate of 1.89%. This approach can be used to improve the usual login-password authentication when the password is no more a secret. This paper innovates using four features to authenticate users.
A Robustness Approach to Inter-Autonomous System Outbound Traffic Engineering

Inter-AS outbound Traffic Engineering (TE) aims to control the flow of traffic exiting an AS so as to optimize inter-AS TE objectives such as load balancing among multiple downstream ASes. The inter-AS traffic matrix is fundamental input for outbound TE and its accuracy is essential for the target performance to be achieved. However, deriving an accurate traffic matrix is far from trivial. This paper proposes a robust approach for outbound TE to manage traffic demand uncertainty through Scenario-based Robust Optimization. The objective of this robust outbound TE is to minimize the worst-case maximum inter-AS link utilization across a set of inter-AS traffic matrices while minimizing the performance deviation from the optimal solutions. Simulation results reveal that the robust outbound TE is capable of achieving reasonably good performance under all the given traffic matrices while non-robust approaches are not.
Physiological ramifications for loggerhead turtles captured in pelagic longlines

Bycatch of endangered loggerhead turtles in longline fisheries results in high rates of post-release mortality that may negatively impact populations. The factors contributing to post-release mortality have not been well studied, but traumatic injuries and physiological disturbances experienced as a result of capture are thought to play a role. The goal of our study was to gauge the physiological status of loggerhead turtles immediately upon removal from longline gear in order to refine our understanding of the impacts of capture and the potential for post-release mortality. We analysed blood samples collected from longline- and hand-captured loggerhead turtles, and discovered that capture in longline gear results in blood loss, induction of the systemic stress response, and a moderate increase in lactate. The method by which turtles are landed and released, particularly if released with the hook or line still attached, may exacerbate stress and lead to chronic injuries, sublethal effects or delayed mortality. Our study is the first, to the best of our knowledge, to document the physiological impacts of capture in longline gear, and our findings underscore the importance of best practices gear removal to promote post-release survival in longline-captured turtles.
A Novel Hybrid Beamforming Algorithm With Unified Analog Beamforming by Subspace Construction Based on Partial CSI for Massive MIMO-OFDM Systems

Hybrid beamforming (HB) has been widely studied for reducing the number of costly radio frequency (RF) chains in massive multiple-input multiple-output (MIMO) systems. However, previous works on HB are limited to a single user equipment (UE) or a single group of UEs, employing the frequency-flat first-level analog beamforming (AB) that cannot be applied to multiple groups of UEs served in different frequency resources in an orthogonal frequency-division multiplexing (OFDM) system. In this paper, a novel HB algorithm with unified AB based on the spatial covariance matrix (SCM) knowledge of all UEs is proposed for a massive MIMO-OFDM system in order to support multiple groups of UEs. The proposed HB method with a much smaller number of RF chains can achieve more than 95% performance of full digital beamforming. In addition, a novel practical subspace construction (SC) algorithm based on partial channel state information is proposed to estimate the required SCM. The proposed SC method can offer more than 97% performance of the perfect SCM case. With the proposed methods, significant cost and power savings can be achieved without large loss in performance. Furthermore, the proposed methods can be applied to massive MIMO-OFDM systems in both time-division duplex and frequency-division duplex.
Factors associated with traumatic symptoms and internalizing problems among adolescents who experienced a traumatic event

Abstract The aim of the present study was to identify factors that are related to the traumatic symptoms and problem behavior among adolescents who experienced the New Years fire in 2001 in Volendam, The Netherlands. Three groups of factors were considered: pre-trauma (personality and coping), trauma-related (physical and emotional proximity to disaster), and post-trauma factors (received social support). Forty-five adolescents completed the questionnaire. Two years after the disaster, these adolescents experienced significant traumatic stress reaction (70% within the clinical range) and showed clinically significant levels of internalizing problems (37%). Pre-trauma, individual factors were identified as the most important predictors of distress, followed by received social support. The indicators of physical and emotional proximity to disaster explained little variance in distress.
The Safety and Efficacy of Adjustable Postoperative Position after Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment

Purpose. To report the safety and efficacy of adjustable postoperative position for rhegmatogenous retinal detachment (RRD). Methods. Retrospective review of 536 consecutive RRD eyes that underwent vitrectomy surgery for retina repair from year 2008 to 2014. The retinal breaks were divided into superior, lateral (nasal, temporal, and macular), and inferior locations, according to the clock of breaks. Patients with superior and lateral break location were allowed to have facedown position or lateral decubitus position postoperatively, while patients with inferior break location were allowed to have facedown position. Results. 403 eyes of 400 patients were included. The mean follow-up interval was 22.7 ± 21.3 months. The overall primary retinal reattachment rate was 93.3%. There were 24 (6.0%), 273 (67.7%), and 106 (26.3%) patients with superior, lateral, and inferior break location, respectively. The primary reattachment rate was 95.8%, 92.3%, and 95.3% accordingly. After further divided the break location into subgroups as a function of duration of symptom, postoperative lens situation, number of retinal breaks, and different vitreous tamponade, the primary reattachment rates were all higher than 82%. Conclusion. Adjustable postoperative positioning is effective and safe for RRD repair with different break locations. Choosing postoperative position appropriately according to retinal break locations could be recommended.
Flexible Seasonal Long Memory and Economic Time Series

We discuss specification, frequency domain estimation and application of flexible fractionally integrated seasonal long memory time series models, which allow for 'chi-squared' (seasonal) unit root testing. We suggest periodogram regression and approximate ML estimation. We successfully apply a flexible model on post war US GNP data, which shows the statistical significance of seasonal 'overdifferencing' due to seasonal adjustment. Application to monthly shipping data for the Sound (1557-1783) shows the order of integration at frequency 0 and 1/12 about 0.5, with lower values at other frequencies. We use several graphical techniques to evaluate the estimation results in the frequency domain.
Efficacy and safety of topical cyclosporine A 0.05% in vernal keratoconjunctivitis.

INTRODUCTION While corticosteroids are an effective choice of treatment for severe vernal keratoconjunctivitis (VKC), their long-term use is restricted due to side effects. This study was conducted to evaluate the efficacy and safety of topical cyclosporine A (CsA) 0.05% in the treatment of VKC. METHODS A total of 30 patients with VKC that was resistant to topical corticosteroids, antihistamines and mast cell stabilisers were treated with topical CsA 0.05%. Patients were evaluated at Weeks 4, 8 and 12 after the initiation of therapy. Symptoms and signs observed before and after treatment were recorded and scores were assigned. Scores for symptoms and signs, the need for topical corticosteroids and ocular side effects were evaluated. RESULTS At baseline, the median values of the symptom and sign scores were 10.0 (range 5.0-18.0) and 6.0 (range 2.0-13.0), respectively. At Week 4 of treatment with topical CsA 0.05%, the median values of the symptom and sign scores were 3.0 (range 0-14.0) and 3.0 (range 0-8.0), respectively. The reductions in the symptom and sign scores were statistically significant. The reduction in the need for corticosteroid was statistically significant by Week 12 of therapy. No significant side effects were reported. CONCLUSION Topical CsA 0.05%, which can help to reduce corticosteroid usage, is an effective and safe alternative for the treatment of resistant VKC. Further studies are needed to determine the optimal duration of therapy and possibility of recurrence.
Assessment of perfusion by dynamic contrast-enhanced imaging using a deconvolution approach based on regression and singular value decomposition

The assessment of tissue perfusion by dynamic contrast-enhanced (DCE) imaging involves a deconvolution process. For analysis of DCE imaging data, we implemented a regression approach to select appropriate regularization parameters for deconvolution using the standard and generalized singular value decomposition methods. Monte Carlo simulation experiments were carried out to study the performance and to compare with other existing methods used for deconvolution analysis of DCE imaging data. The present approach is found to be robust and reliable at the levels of noise commonly encountered in DCE imaging, and for different models of the underlying tissue vasculature. The advantages of the present method, as compared with previous methods, include its efficiency of computation, ability to achieve adequate regularization to reproduce less noisy solutions, and that it does not require prior knowledge of the noise condition. The proposed method is applied on actual patient study cases with brain tumors and ischemic stroke, to illustrate its applicability as a clinical tool for diagnosis and assessment of treatment response.
Reflection and scattering characteristics of reflectors in SAW tags

As a foundation of an optimal design for SAW tags,the reflection, scattering, and transmission of the reflector composed of a few electrodes are discussed. A source regeneration method based on Green's function and the finite element method/boundary element method is used to obtain the reflection coefficient and the scattering coefficient for the short-circuited and open circuit reflectors. Examples are presented to show how one can use structure variance to satisfy the requirements for SAW tag design according to the reflection and scattering characteristics.