Miracle-dz/UniFAR-FTUs huggingface dataset:
Thoracoscopic lobectomy is associated with improved short-term and equivalent oncological outcomes compared with open lobectomy for clinical Stage I non-small-cell lung cancer: a propensity-matched analysis of 963 cases.

OBJECTIVES Previous literature has reported lower morbidity for video-assisted thoracoscopic surgery lobectomy (VL) compared with open lobectomy (OL); however, most comparative studies have been retrospective and have failed to compare well-matched patient groups, therefore allowing selection bias to influence results. Furthermore, oncological adequacy of VL has recently been questioned, particularly with respect to lymphadenectomy. This study aimed to evaluate short- and long-term outcomes of a large cohort of consecutive patients with c-stage I non-small-cell lung cancer (NSCLC) that underwent either VL or OL. METHODS Consecutive patients with c-stage I NSCLC who underwent lobectomy without preoperative therapy were reviewed. Univariable, multivariable and propensity-matched analyses were performed. VL patients who underwent conversion to OL were analysed within the VL group. RESULTS VL was performed in 307 (32%) patients and OL in 656 (68%). Twenty-two (7%) patients converted from VL to OL. Although there were no differences in overall p-stage grouping, there were fewer patients with pT2 tumours in the VL group (39 vs 48%, P = 0.012) and fewer patients with squamous cell histology (26 vs 18%, P = 0.006). These differences resolved after propensity matching. In unmatched and matched analyses, VL was associated with less overall morbidity, less pulmonary morbidity, fewer atrial arrhythmias, shorter chest tube duration and shorter hospital stay than patients who had OL. Thirty-day in-hospital mortality was 0.3 and 1.4%, for VL and OL groups, respectively (P = NS). In unmatched analysis (log rank), 5-year survival favoured VL (78 vs 68%, P = 0.007); however, after propensity matching there was only a trend towards improved survival with VL (78 vs 73%, P = 0.071). Multivariable Cox regression analysis revealed VL (hazard ratio (HR) 0.64, 95% confidence interval (CI) 0.46-0.92), male sex (HR 1.43, 95% CI 1.10-1.86), Zubrod performance status (HR 3.42, 95% CI 1.26-9.29) and increasing age (HR 1.04, 95% CI 1.03-1.06) to be independent predictors of survival. CONCLUSIONS Patients with clinical Stage I NSCLC undergoing VL have less perioperative morbidity compared with matched OL controls. Regional lymphadenectomy, nodal upstaging, overall and disease-free survival were similar between VL and OL groups. In experienced centres, VL is an acceptable operation for patients with c-stage I NSCLC.
Downregulation of Endothelial MicroRNA-200b Supports Cutaneous Wound Angiogenesis By Desilencing GATA Binding Protein 2 and Vascular Endothelial Growth Factor Receptor 2

Objective—MicroRNAs (miRs) regulate angiogenesis by posttranscriptional silencing of target genes. The significance of angiostatic miR-200b in switching on skin wound angiogenesis was tested. Methods and Results—Wounding caused imminent and transient downregulation of miR-200b in dermal wound-edge endothelial cells. Derailing this injury response by lentiviral delivery of miR-200b in vivo impaired wound angiogenesis. Computational prediction, target reporter luciferase assay, and Western blot analysis provided first evidence that miR-200b targets globin transcription factor binding protein 2 (GATA2) and vascular endothelial growth factor receptor 2 (VEGFR2). Overexpression of GATA2 or VEGFR2 in endothelial cells rescued the angiostatic effect of miR-200b in vitro. Downregulation of miR-200b derepressed GATA2 and VEGFR2 expression to switch on wound angiogenesis, which was disrupted in diabetic wounds. Treatment of endothelial cells with tumor necrosis factor-&agr;, a proinflammatory cytokine abundant in diabetic wounds, induced miR-200b expression, silenced GATA2 and VEGFR2, and suppressed angiogenesis. These outcomes were attenuated using anti-miR-200b strategy. Neutralization of tumor necrosis factor-&agr; in the diabetic wounds improved wound angiogenesis and closure, which was accompanied by downregulation of miR-200b expression and desilencing of GATA2 and VEGFR2. Conclusion—Injury-induced repression of miR-200b turned on wound angiogenesis. In mice with diabetes mellitus,excessive tumor necrosis factor-&agr; induced miR-200b blunting proangiogenic functions of GATA2 and VEGFR2.
Correlation, concepts and cross‐linguistic differences

As the commentaries make clear, our results bear on one of the most fundamental issues in cognitive development: the degree to which thought is determined by language. The language effect reported in the target article is small but informative: language is one force creating ontological distinctions. In this reply, we concentrate on three issues pertinent to the commentators’ reactions to the target article. These are: (1) the nature of correlational learning, (2) what concepts are (or could be) and finally (3) the nature of cross-linguistic differences.
Effect of Rosiglitazone Treatment on Plaque Inflammation and Collagen Content in Nondiabetic Patients: Data From a Randomized Placebo-Controlled Trial

Background—Therapeutic strategies to stabilize advanced arteriosclerotic lesions may prevent plaque rupture and reduce the incidence of acute coronary syndromes. Thiazolidinediones (TZDs), like rosiglitazone, are oral antidiabetic drugs with additional antiinflammatory and potential antiatherogenic properties. In a randomized, placebo-controlled, single-blind trial, we examined the effect of 4 weeks of rosiglitazone therapy on histomorphological characteristics of plaque stability in artery specimen of nondiabetic patients scheduled for elective carotid endarterectomy. Methods and Results—A total of 24 nondiabetic patients with symptomatic carotid artery stenosis were randomly assigned to rosiglitazone (4 mg BID) or placebo in addition to standard therapy. In this population of nondiabetic patients, rosiglitazone treatment did not significantly change fasting blood glucose, fasting insulin, or lipid parameters. In contrast, rosiglitazone significantly reduced CD4-lymphocyte content as well as macrophage HLA-DR expression in the shoulder region, reflecting less inflammatory activation of these cells by lymphocyte interferon-&ggr;. Moreover, rosiglitazone significantly increased plaque collagen content (7.7±1.6% versus 3.7±0.7% of plaque area; P=0.036) compared with placebo, suggesting that TZD treatment may stabilize arteriosclerotic lesions. In addition, rosiglitazone reduced serum levels of 2 inflammatory arteriosclerosis markers: C-reactive protein and serum amyloid A. Conclusions—Four weeks of treatment with rosiglitazone significantly reduces vascular inflammation in nondiabetic patients, leading to a more stable type of arteriosclerotic lesion.
Seasonal Cycle-El Niño Relationship: Validation of Hypotheses

The present paper examines ways in which the seasonal cycle influences the evolution of El Nino in the tropical Pacific. The following hypotheses and associated physical mechanisms are investigated: (i) Hy- pothesis 1 (H1)—the seasonal warming of the cold tongue early in the calendar year (January-April) favors the initial growth of an event; (ii) hypothesis 2 (H2)—during an event, the warm surface waters migrating in the western basin from the Southern to the Northern Hemisphere during the northern spring (April-May) trigger enhanced convection along the equator, which contributes to reinforce the event; and (iii) hypothesis 3 (H3)—the warm surface waters returning in the western basin from the Northern to the Southern Hem- isphere toward the end of the calendar year (November-January) favor the demise of ongoing events. Hypothesis-validation experiments are performed with a coupled atmosphere-ocean general circulation model (CGCM)—the tropical Pacific version of the University of California, Los Angeles (UCLA) CGCM. The anomaly-coupling technique is applied, in which the simulated seasonal cycle and interannual variability can be separated and artificially modified to highlight the aspect targeted for examination, thus allowing for comparisons of simulations in which seasonal conditions in the CGCM's atmospheric component are either fixed or time varying. The results obtained in the experiments are supportive of hypotheses H1 and H3. No supportive evidence is found for the validity of hypothesis H2.
In Vivo Lymphocyte‐Mediated Myocardial Injuries Demonstrated by Adoptive Transfer of Experimental Autoimmune Myocarditis

BackgroundTo elucidate the mechanisms of immune-related myocardial injuries, we examined whether autoimmune myocarditis was passively transferable by use of humoral or cellular factors. Methods and ResultsActive myocarditis was elicited in Lewis rats by immunization with human cardiac myosin fraction in complete Freund's adjuvant. This experimental myocarditis was characterized by macroscopic features such as pericardial effusion, enlargement of the heart, and gray discoloration of the cardiac surface. Histologically, extensive myocardial necrosis and numerous inflammatory cell infiltrations were observed. Interestingly, multinucleated giant cells were frequently observed in the lesions. Transfer of the disease by the humoral factor was examined by use of fresh sera and immunoglobulin fraction of pooled sera from rats with severe myocarditis, and transfer by the cellular factor was tested by use of spleen cells and lymph node cells from the diseased rats. When naive Lewis rats were given 15.75 mg of immunoglobulin fraction, no particular change was observed in the hearts. Fresh sera also could not elicit myocarditis in recipient rats. In contrast, intravenous injection of spleen cells or lymph node cells that were cultured for 3 days in the presence of 1 μg/ml of concanavalin A elicited severe myocarditis. The macroscopic and microscopic findings of passively transferred myocarditis are essentially the same as those found in actively induced myocarditis. Multinucleated giant cells were also observed in the lesions of transferred myocarditis. ConclusionsThis study demonstrates direct evidence for in vivo lymphocyte-mediated myocardial injuries.
CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine.

BACKGROUND & AIMS Studies are aimed to determine the role of CD36 in intestinal lipid absorption. METHODS Knock-out (KO) and wild-type (WT) lymph fistula mice were used to study fatty acids (FA) and cholesterol uptake, and chylomicron formation and secretion. Uptake of FA and cholesterol was studied by using sucrose polybehenate and fecal dual isotope methods, respectively. RESULTS The CD36 KO exhibited significant accumulation of dietary cholesterol in the intestinal lumen at the end of 6-hour lipid infusion and significant reduction of dietary cholesterol transport into the lymph. Fecal dual isotope studies, however, did not show any significant difference in cholesterol uptake, suggesting that given sufficient time, the KO intestine could compensate for the reduced cholesterol uptake observed in the acute lymph fistula studies. Recovery of dietary FA in the intestinal lumen was comparable between WT and KO, consistent with the sucrose polybehenate study. However, the KO mice accumulated more, albeit not significantly, dietary triacylglycerols in the intestine, followed by a significant reduction in lymphatic transport. The ratio of intestinal dietary triacylglycerols to FA was not higher in WT than KO, arguing against impaired lipid esterification. It is rather a deficiency in the formation and secretion of chylomicrons, as supported by the significantly less apolipoprotein B-48 and the smaller, albeit not significantly, lipoprotein particles secreted into the lymph of the KO. CONCLUSIONS CD36 may play an important role in chylomicron formation and secretion and may also facilitate cholesterol uptake in the proximal intestine.
Naturalistic Assessment of Everyday Activities and Prompting Technologies in Mild Cognitive Impairment

Abstract Older adults with mild cognitive impairment (MCI) often have difficulty performing complex instrumental activities of daily living (IADLs), which are critical to independent living. In this study, amnestic multi-domain MCI (N = 29), amnestic single-domain MCI (N = 18), and healthy older participants (N = 47) completed eight scripted IADLs (e.g., cook oatmeal on the stove) in a smart apartment testbed. We developed and experimented with a graded hierarchy of technology-based prompts to investigate both the amount of prompting and type of prompts required to assist individuals with MCI in completing the activities. When task errors occurred, progressive levels of assistance were provided, starting with the lowest level needed to adjust performance. Results showed that the multi-domain MCI group made more errors and required more prompts than the single-domain MCI and healthy older adult groups. Similar to the other two groups, the multi-domain MCI group responded well to the indirect prompts and did not need a higher level of prompting to get back on track successfully with the tasks. Need for prompting assistance was best predicted by verbal memory abilities in multi-domain amnestic MCI. Participants across groups indicated that they perceived the prompting technology to be very helpful. (JINS, 2013, 19, 1–11)
Outcome prediction by extranodal involvement, IPI, R‐IPI, and NCCN‐IPI in the PET/CT and rituximab era: A Danish–Canadian study of 443 patients with diffuse‐large B‐cell lymphoma

18F‐fluorodeoxyglucose PET/CT (PET/CT) is the current state‐of‐the‐art in the staging of diffuse large B‐cell lymphoma (DLBCL) and has a high sensitivity for extranodal involvement. Therefore, reassessment of extranodal involvement and the current prognostic indices in the PET/CT era is warranted. We screened patients with newly diagnosed DLBCL seen at the academic centers of Aalborg, Copenhagen, and British Columbia for eligibility. Patients that had been staged with PET/CT and treated with R‐CHOP(‐like) 1st line treatment were retrospectively included. In total 443 patients met the inclusion criteria. With a median follow‐up of 2.4 years, the 3‐year overall (OS) and progression‐free survival (PFS) were 73% and 69%, respectively. The Ann Arbor classification had no prognostic impact in itself with the exception of stage IV disease (HR 2.14 for PFS, P<0.01). Extranodal involvement was associated with a worse outcome in general, and in particular for patients with involvement of >2 extranodal sites, including HR 7.81 (P < 0.001) for PFS for >3 sites. Bone/bone marrow involvement was the most commonly involved extranodal site identified by PET/CT (29%) and was associated with an inferior PFS and OS. The IPI, R‐IPI, and NCCN‐IPI were predictive of PFS and OS, and the two latter could identify a very good prognostic subgroup with 3‐year PFS and OS of 100%. PET/CT‐ascertained extranodal involvement in DLBCL is common and involvement of >2 extranodal sites is associated with a dismal outcome. The IPI, R‐IPI, and NCCN‐IPI predict outcome with high accuracy. Am. J. Hematol. 90:1041–1046, 2015. © 2015 Wiley Periodicals, Inc.
Why inclusive fitness can make it adaptive to produce less fit extra-pair offspring

Social monogamy predominates in avian breeding systems, but most socially monogamous species engage in promiscuous extra-pair copulations (EPCs). The reasons behind this remain debated, and recent empirical work has uncovered patterns that do not seem to fit existing hypotheses. In particular, some results seem to contradict the inbreeding avoidance hypothesis: females can prefer extra-pair partners that are more closely related to them than their social partners, and extra-pair young can have lower fitness than within-pair young. Motivated by these studies, we show that such results can become explicable when an asymmetry in inbreeding tolerance between monogamy and polygamy is extended to species that combine both strategies within a single reproductive season. Under fairly general conditions, it can be adaptive for a female to choose an unrelated social partner, but inbreed with an extra-pair partner. Inbreeding depression is compensated for by inclusive fitness benefits, which are only fully realized in EPCs. We also show that if a female has already formed a suboptimal social bond, there are scenarios where it is beneficial to engage in EPCs with less related males, and others where EPCs with more related males increase her inclusive fitness. This has implications for detecting general relatedness or fitness trends when averaged over several species.
A support vector machine classifier of emotion from voice and facial expression data

The paper provides a novel approach to emotion recognition from facial expression and voice of subjects. The subjects are asked to manifest their emotional exposure in both facial expression and voice, while uttering a given sentence. Facial features including mouth-opening, eye-opening, eyebrow-constriction, and voice features including, first three formants: F1, F2, and F3, and respective powers at those formants, and pitch are extracted for 7 different emotional expressions of each subject. A linear Support Vector Machine classifier is used to classify the extracted feature vectors into different emotion classes. Sensitivity of the classifier to Gaussian noise is studied, and experimental results confirm that the recognition accuracy of emotion up to a level of 95% is maintained, even when the mean and standard deviation of noise are as high as 5% and 20% respectively over the individual features. A further analysis to identify the importance of individual features reveals that mouthopening and eye-opening are primary features, in absence of which classification accuracy falls off by a large margin of more than 22%.
Hidradenitis Suppurativa: Successful Treatment Using Carbon Dioxide Laser Excision and Marsupialization

BACKGROUND Hidradenitis suppurativa (HS) is a disease associated with significant patient morbidity and less‐than‐ideal therapies. OBJECTIVES To determine the long‐ and short‐term benefits of carbon dioxide (CO2) laser excision and marsupialization in the management of persisent lesions of HS. METHODS Patients with long‐standing lesions of HS were treated using a CO2 laser to excise inflammatory and draining masses. RESULTS One hundred eighty‐five areas were treated in 61 patients using the CO2 laser excision and marsupialization technique in 154 sessions. Local anesthesia was used for all but three sessions. Healing occurred primarily through secondary intention. In follow‐up from 1 to 19 years, acceptable to excellent qualities of healing occurred. Recurrence within the treated area occurred in two of 185 sites treated. CONCLUSION CO2 laser excision and marsupialization appears to be an effective therapy for management of persisent or late‐stage HS. There was good patient comfort during and after treatment, lower costs than with inpatient modalities, good healing, and minimal risk of recurrence within the treated areas. The authors have indicated no significant interest with commercial supporters.
Adaptive Ensembling of Semi-Supervised Clustering Solutions

Conventional semi-supervised clustering approaches have several shortcomings, such as (1) not fully utilizing all useful must-link and cannot-link constraints, (2) not considering how to deal with high dimensional data with noise, and (3) not fully addressing the need to use an adaptive process to further improve the performance of the algorithm. In this paper, we first propose the transitive closure based constraint propagation approach, which makes use of the transitive closure operator and the affinity propagation to address the first limitation. Then, the random subspace based semi-supervised clustering ensemble framework with a set of proposed confidence factors is designed to address the second limitation and provide more stable, robust, and accurate results. Next, the adaptive semi-supervised clustering ensemble framework is proposed to address the third limitation, which adopts a newly designed adaptive process to search for the optimal subspace set. Finally, we adopt a set of nonparametric tests to compare different semi-supervised clustering ensemble approaches over multiple datasets. The experimental results on 20 real high dimensional cancer datasets with noisy genes and 10 datasets from UCI datasets and KEEL datasets show that (1) The proposed approaches work well on most of the real-world datasets. (2) It outperforms other state-of-the-art approaches on 12 out of 20 cancer datasets, and 8 out of 10 UCI machine learning datasets.
A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients

Objective:The impact of a contributive result of open-lung biopsy on the outcome of patients with acute respiratory distress syndrome (ARDS) has not been extensively investigated. The aim of this study was therefore to determine the rate of contributive open-lung biopsy and whether it improved the prognosis of ARDS patients. Design:Prospective study conducted during an 8-yr period. Setting:A 14-bed medico-surgical intensive care unit and a 12-bed medical intensive care unit from the same hospital. Patients:One hundred open-lung biopsies were performed in 100 patients presenting ARDS. Interventions:Open-lung biopsy was performed after ≥5 days of evolution of ARDS when there was no improvement in the respiratory status despite negative microbiological samples cultures and potential indication for corticosteroid treatment. Measurements and Main Results:Ten patients presented a mechanical complication following open-lung biopsy (two pneumothoraces and eight moderate air leaks). The unique independent factor associated with this complication was the minute ventilation when open-lung biopsy was performed (odds ratio, 1.20; 95% confidence interval, 1.03–1.41; p = .02). Fibrosis was noted in 53 patients but was associated with an infection in 29 of these 53 patients (55%). A contributive result of open-lung biopsy (defined as the addition of a new drug) was noted in 78 patients. Simplified Acute Physiology Score II was the only independent predictive factor of a contributive open-lung biopsy (odds ratio, 0.96; 95% confidence interval, 0.92–0.99; p = .04). Survival was higher in patients with a contributive open-lung biopsy (67%) than in patients in whom open-lung biopsy results did not modify the treatment (14%) (p < .001). The factors predicting survival were a contributive result of open-lung biopsy, female gender, and the Organ System Failures score the day of open-lung biopsy. Conclusions:The present study shows that open-lung biopsy provided a contributive result in 78% of ARDS patients with a negative bronchoalveolar lavage. Survival of ARDS patients improved when open-lung biopsy was contributive.