Miracle-dz/UniFAR-FTUs huggingface dataset:
Eliciting mixed emotions: a meta-analysis comparing models, types, and measures

The idea that people can experience two oppositely valenced emotions has been controversial ever since early attempts to investigate the construct of mixed emotions. This meta-analysis examined the robustness with which mixed emotions have been elicited experimentally. A systematic literature search identified 63 experimental studies that instigated the experience of mixed emotions. Studies were distinguished according to the structure of the underlying affect model—dimensional or discrete—as well as according to the type of mixed emotions studied (e.g., happy-sad, fearful-happy, positive-negative). The meta-analysis using a random-effects model revealed a moderate to high effect size for the elicitation of mixed emotions (dIG+ = 0.77), which remained consistent regardless of the structure of the affect model, and across different types of mixed emotions. Several methodological and design moderators were tested. Studies using the minimum index (i.e., the minimum value between a pair of opposite valenced affects) resulted in smaller effect sizes, whereas subjective measures of mixed emotions increased the effect sizes. The presence of more women in the samples was also associated with larger effect sizes. The current study indicates that mixed emotions are a robust, measurable and non-artifactual experience. The results are discussed in terms of the implications for an affect system that has greater versatility and flexibility than previously thought.
Faking the IAT: Aided and Unaided Response Control on the Implicit Association Tests

One pragmatic goal of implicit tools like the Implicit Association Tests (IAT) is to rule out self-presentation and controlled responding. Three experiments examined whether the IAT meets this goal, using Turkish and German groups along with positive and negative traits. Experiment 1 was an Internet study. After completing a naïve IAT pretest, participants were instructed to fake on a posttest in 3 graded conditions that differed in the explicitness of faking instructions. Experiment 2 replicated and extended the approach in the laboratory, including a no-pretest condition. Results demonstrate that participants who intended to fake were successful, provided the experience of a pretest. Experiment 3 ruled out an alternative account of faking in terms of pretest experience. Faking was mostly due to slow-down on compatible trials, but a notable speed-up on incompatible trials also occurred. Faking remained inconspicuous, especially with nonblatant instructions; experts failed to identify faked data sets.
Decreased Functional Brain Connectivity in Adolescents with Internet Addiction

Background Internet addiction has become increasingly recognized as a mental disorder, though its neurobiological basis is unknown. This study used functional neuroimaging to investigate whole-brain functional connectivity in adolescents diagnosed with internet addiction. Based on neurobiological changes seen in other addiction related disorders, it was predicted that connectivity disruptions in adolescents with internet addiction would be most prominent in cortico-striatal circuitry. Methods Participants were 12 adolescents diagnosed with internet addiction and 11 healthy comparison subjects. Resting-state functional magnetic resonance images were acquired, and group differences in brain functional connectivity were analyzed using the network-based statistic. We also analyzed network topology, testing for between-group differences in key graph-based network measures. Results Adolescents with internet addiction showed reduced functional connectivity spanning a distributed network. The majority of impaired connections involved cortico-subcortical circuits (∼24% with prefrontal and ∼27% with parietal cortex). Bilateral putamen was the most extensively involved subcortical brain region. No between-group difference was observed in network topological measures, including the clustering coefficient, characteristic path length, or the small-worldness ratio. Conclusions Internet addiction is associated with a widespread and significant decrease of functional connectivity in cortico-striatal circuits, in the absence of global changes in brain functional network topology.
Nonlinear scaling of space use in human hunter–gatherers

Use of space by both humans and other mammals should reflect underlying physiological, ecological, and behavioral processes. In particular, the space used by an individual for its normal activities should reflect the interplay of three constraints: (i) metabolic resource demand, (ii) environmental resource supply, and (iii) social behaviors that determine the extent to which space is used exclusively or shared with other individuals. In wild mammals, there is an allometric scaling relation between the home range of an individual and its body size: Larger mammals require more space per individual, but this relation is additionally modified by productivity of the environment, trophic niche, sociality, and ability to defend a territory [Kelt DA, Van Vuren D (1999) Ecology 80: 337–340; Kelt DA, Van Vuren D (2001) Am Nat 157:637–645; Haskell JP, Ritchie ME, Olff H (2002) Nature 418:527–530; Damuth J (1987) Biol J Linn Soc 31:193–246; Damuth J (1981) Nature 290:699–700; and other previously published work]. In this paper we show how similar factors affect use of space by human hunter–gatherers, resulting in a nonlinear scaling relation between area used per individual and population size. The scaling exponent is less than one, so the area required by an average individual decreases with increasing population size, because social networks of material and information exchange introduce an economy of scale.
Development and Evaluation of a 16S Ribosomal DNA Array-Based Approach for Describing Complex Microbial Communities in Ready-To-Eat Vegetable Salads Packed in a Modified Atmosphere

ABSTRACT There is a clear need for new approaches in the field of microbial community analyses, since the methods used can be severely biased. We have developed a DNA array-based method that targets16S ribosomal DNA (rDNA), enabling the direct detection and quantification of microorganisms from complex communities without cultivation. The approach is based on the construction of specific probes from the 16S rDNA sequence data retrieved directly from the communities. The specificity of the assay is obtained through a combination of DNA array hybridization and enzymatic labeling of the constructed probes. Cultivation-dependent assays (enrichment and plating) and cultivation-independent assays (direct fluorescence microscopy and scanning electron microscopy) were used as reference methods in the development and evaluation of the method. The description of microbial communities in ready-to-eat vegetable salads in a modified atmosphere was used as the experimental model. Comparisons were made with respect to the effect of storage at different temperatures for up to 12 days and with respect to the geographic origin of the crisphead lettuce (Spanish or Norwegian), the main salad component. The conclusion drawn from the method comparison was that the DNA array-based method gave an accurate description of the microbial communities. Pseudomonas spp. dominated both of the salad batches, containing either Norwegian or Spanish lettuce, before storage and after storage at 4°C. The Pseudomonas population also dominated the batch containing Norwegian lettuce after storage at 10°C. On the contrary, Enterobacteriaceae and lactic acid bacteria dominated the microbial community of the batch containing Spanish lettuce after storage at 10°C. In that batch, the Enterobacteriaceae also were abundant after storage at 4°C as well as before storage. The practical implications of these results are that microbial communities in ready-to-eat vegetable salads can be diverse and that microbial composition is dependent both on the origin of the raw material and on the storage conditions.
Cardiac Repolarization and Autonomic Regulation during Short-Term Cold Exposure in Hypertensive Men: An Experimental Study

Objectives The aim of our study was to assess the effect of short-term cold exposure, typical in subarctic climate, on cardiac electrical function among untreated middle-aged hypertensive men. Methods We conducted a population-based recruitment of 51 hypertensive men and a control group of 32 men without hypertension (age 55–65 years) who underwent whole-body cold exposure (15 min exposure to temperature −10°C, wind 3 m/s, winter clothes). Conduction times and amplitudes, vectorcardiography, arrhythmias, and heart rate variability (autonomic nervous function) were assessed. Results Short-term cold exposure increased T-peak to T-end interval from 67 to 72 ms (p<0.001) and 71 to 75 ms (p<0.001) and T-wave amplitude from 0.12 to 0.14 mV (p<0.001) and from 0.17 to 0.21 mV (p<0.001), while QTc interval was shortened from 408 to 398 ms (p<0.001) and from 410 to 401 ms (p<0.001) among hypertensive men and controls, respectively. Cold exposure increased both low (from 390 to 630 ms2 (p<0.001) and 380 to 700 ms2 (p<0.001), respectively) and high frequency heart rate variability (from 90 to 190 ms2 (p<0.001) and 150 to 300 ms2 (p<0.001), respectively), while low-to-high frequency-ratio was reduced. In addition, the frequency of ventricular ectopic beats increased slightly during cold exposure. The cold induced changes were similar between untreated hypertensive men and controls. Conclusions Short-term cold exposure with moderate facial and mild whole body cooling resulted in prolongation of T-peak to T-end interval and higher T-wave amplitude while QTc interval was shortened. These changes of ventricular repolarization may have resulted from altered cardiac autonomic regulation and were unaffected by untreated hypertension. Trial Registration ClinicalTrials.gov NCT02007031
Effect of physician disclosure of specialty bias on patient trust and treatment choice

Significance Disclosure policies, intended to protect consumers, are a popular solution across a range of industries such as health care, financial investments, mortgages, and other services in which professional advisors may suffer from potential bias from misaligned incentives. Using field data (recorded transcripts of surgeon–patient consultations) and a randomized controlled laboratory experiment, we examine and find that disclosures of specialty bias increase patients’ trust and their likelihood of choosing a treatment in accordance with the physicians’ specialty. Professionals and policy makers should be aware of the implications on advisee trust and choice when advocating for the disclosure of advisor bias. This paper explores the impact of disclosures of bias on advisees. Disclosure—informing advisees of a potential bias—is a popular solution for managing conflicts of interest. Prior research has focused almost exclusively on disclosures of financial conflicts of interest but little is known about how disclosures of other types of biases could impact advisees. In medicine, for example, physicians often recommend the treatment they specialize in; e.g., surgeons are more likely to recommend surgery than nonsurgeons. In recognition of this bias, some physicians inform patients about their specialty bias when other similarly effective treatment options exist. Using field data (recorded transcripts of surgeon–patient consultations) from Veteran Affairs hospitals and a randomized controlled laboratory experiment, we examine and find that disclosures of specialty bias increase patients’ trust and their likelihood of choosing a treatment in accordance with the physicians’ specialty. Physicians in the field also increased the strength of their recommendation to have the specialty treatment when they disclosed their bias or discussed the opportunity for the patient to seek a consultation with a physician from another specialty. These findings have important implications for handling advisor bias, shared advisor–advisee decision-making, and disclosure policies.
Endurance training in early life results in long‐term programming of heart mass in rats

Being born small for gestational age increases the risk of developing adult cardiovascular and metabolic diseases. This study aimed to examine if early‐life exercise could increase heart mass in the adult hearts from growth restricted rats. Bilateral uterine vessel ligation to induce uteroplacental insufficiency and fetal growth restriction in the offspring (Restricted) or sham surgery (Control) was performed on day 18 of gestation in WKY rats. A separate group of sham litters had litter size reduced to five pups at birth (Reduced litter), which restricted postnatal growth. Male offspring remained sedentary or underwent treadmill running from 5 to 9 weeks (early exercise) or 20 to 24 weeks of age (later exercise). Remarkably, in Control, Restricted, and Reduced litter groups, early exercise increased (P < 0.05) absolute and relative (to body mass) heart mass in adulthood. This was despite the animals being sedentary for ~4 months after exercise. Later exercise also increased adult absolute and relative heart mass (P < 0.05). Blood pressure was not significantly altered between groups or by early or later exercise. Phosphorylation of Akt Ser473 in adulthood was increased in the early exercise groups but not the later exercise groups. Microarray gene analysis and validation by real‐time PCR did not reveal any long‐term effects of early exercise on the expression of any individual genes. In summary, early exercise programs the heart for increased mass into adulthood, perhaps by an upregulation of protein synthesis based on greater phosphorylation of Akt Ser473.
Self‐organization in the developing nervous system: Theoretical models

Sensory maps in the nervous system often connect to each other in a topographic fashion. This is most strikingly seen in the visual system, where neighboring neurons in the retina project to neighboring neurons in the target structure, such as the superior colliculus. This article discusses the developmental mechanisms that are involved in the formation of topographic maps, with an emphasis on the role of theoretical models in helping us to understand these mechanisms. Recent experimental advances in studying the roles of guidance molecules and patterns of spontaneous activity mean that there are new challenges to be addressed by theoretical models. Key questions include understanding what instructional cues are present in the patterns of spontaneous activity, and how activity and guidance molecules might interact. Our discussion concludes by comparing development of visual maps with development of maps in the olfactory system, where the influence of neural activity seems to differ.
Antimicrobial Activity of Peptides Derived from Olive Flounder Lipopolysaccharide Binding Protein/Bactericidal Permeability-Increasing Protein (LBP/BPI)

We describe the antimicrobial function of peptides derived from the C-terminus of the olive flounder LBP BPI precursor protein. The investigated peptides, namely, ofLBP1N, ofLBP2A, ofLBP4N, ofLBP5A, and ofLBP6A, formed α-helical structures, showing significant antimicrobial activity against several Gram-negative bacteria, Gram-positive bacteria, and the yeast Candida albicans, but very limited hemolytic activities. The biological activities of these five analogs were evaluated against biomembranes or artificial membranes for the development of candidate therapeutic agents. Gel retardation studies revealed that peptides bound to DNA and inhibited migration on an agarose gel. In addition, we demonstrated that ofLBP6A inhibited polymerase chain reaction. These results suggested that the ofLBP-derived peptide bactericidal mechanism may be related to the interaction with intracellular components such as DNA or polymerase.
Interleukin-10 gene promoter polymorphisms and risk of gastric cancer in a Chinese population: single nucleotide and haplotype analyses.

OBJECTIVES Interleukin (IL) -10 is a potent cytokine with a dual ability to immunosuppress or immunostimulate. We aimed to explore the association of IL10 promoter polymorphisms with risk of gastric cancer (GC) in a Han population in Southwestern China. METHODS We enrolled 308 pairs of GC and control subjects from four hospitals and a community between October 2010 and August 2011 in a 1:1 matched case-control design. Demographic information was collected using a designed questionnaire. IL10-592 A>C and IL10-1082 A>G polymorphisms were determined by Sequenom MassARRAY analysis. RESULTS Patients with GC reported statistically higher proportions of family history of cancer (29.9% versus 10.7%, P<0.01) and alcohol drinking (54.6% versus 43.2%, P<0.01) than did controls. Similar results were observed in comparison between non-cardia GC patients and controls (P<0.01 and P=0.03). Variant genotypes of IL10-592 A>C and IL10-1082 A>G were not associated with overall GC risk (adjusted OR, 0.94, 95% CI, 0.66-1.33; adjusted OR, 1.00, 95% CI, 0.62-1.60). Sub-analysis showed that the IL10-592 AC/CC variant genotype was associated with decreased non-cardia GC risk (adjusted OR, 0.58; 95% CI, 0.36-0.95). No association was found between any of the IL10 haplotypes established from two polymorphisms and risk of non-cardia GC. CONCLUSIONS In conclusion, our data do not link the two SNPs of IL10-592 and IL10-1082 with overall GC risk. We demonstrate that IL10-592 polymorphism is associated with protective effect against non-cardia GC. Our findings may offer insight into risk associated with the development of GC in this region.
Distortion of maternal-fetal angiotensin II type 1 receptor allele transmission in pre-eclampsia.

OBJECTIVE: To investigate the fetal angiotensin II type 1 receptor genotype in pre-eclampsia. DESIGN: Case-control study. POPULATION: Forty-one maternal-fetal pairs from pre-eclamptic pregnancies and 80 maternal-fetal pairs from normotensive pregnancies. METHODS: Maternal and fetal DNA was genotyped at three diallelic polymorphisms, at nucleotides 573, 1062, and 1166, in the coding exon of the angiotensin II type 1 receptor gene, and at a dinucleotide repeat polymorphism in its 3' flanking region. RESULTS: Allele and genotype frequencies at the four polymorphic regions investigated did not differ between pre-eclamptic and normotensive groups, in either fetal or maternal samples. Mothers heterozygous for the dinucleotide repeat allele designated A4 transmitted this allele to the fetus in 15 of 18 informative pre-eclamptic pregnancies and in eight of 26 normotensive pregnancies. This was greater than the expected probability in pre-eclamptic pregnancies (p=0.04) and less than expected in normotensive pregnancies (p<0.005). The 573T variant, which is in partial linkage disequilibrium with the A4 allele, showed a similar distortion of maternal-fetal transmission. CONCLUSION: Angiotensin II type 1 receptor gene expression in the fetus may contribute to the aetiology of pre-eclampsia. It is unclear whether susceptibility is conferred by the fetal genotype acting alone, or by allele sharing by mother and fetus. Possible mechanisms for the effect of the angiotensin II type 1 receptor gene are suggested by the association of the 573T variant with low levels of surface receptor expression on platelets. If receptor expression is similarly genetically determined in the placenta, responsiveness to angiotensin II may be affected, with the potential to influence placentation or placental prostaglandin secretion.
BestConfig: tapping the performance potential of systems via automatic configuration tuning

An ever increasing number of configuration parameters are provided to system users. But many users have used one configuration setting across different workloads, leaving untapped the performance potential of systems. A good configuration setting can greatly improve the performance of a deployed system under certain workloads. But with tens or hundreds of parameters, it becomes a highly costly task to decide which configuration setting leads to the best performance. While such task requires the strong expertise in both the system and the application, users commonly lack such expertise. To help users tap the performance potential of systems, we present Best Config, a system for automatically finding a best configuration setting within a resource limit for a deployed system under a given application workload. BestConfig is designed with an extensible architecture to automate the configuration tuning for general systems. To tune system configurations within a resource limit, we propose the divide-and-diverge sampling method and the recursive bound-and-search algorithm. BestConfig can improve the throughput of Tomcat by 75%, that of Cassandra by 63%, that of MySQL by 430%, and reduce the running time of Hive join job by about 50% and that of Spark join job by about 80%, solely by configuration adjustment.
Investigation of the permeability and optical clearing ability of different analytes in human normal and cancerous breast tissues by spectral domain OCT

The potential of OCT applied for early breast cancer detection attracted significant efforts. The permeability coefficients and the percentages of OCT signal enhancement for normal and cancerous breast tissues have been investigated from the experiments of 20% glucose, 40% glucose, and 20% mannitol in vitro. Obtained results indicate that the permeability coefficient in breast cancer tissue is prominently larger than that in normal breast tissue, while the optical clearing effect is just the reverse to that for each agent. The results suggest that OCT has the ability to distinguish cancer tissue from different aspect. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Optoelectronic characterization of transmission lines and waveguides by terahertz time-domain spectroscopy

An overview is presented of an experimental search for an ultrawide-band transmission channel with low dispersion and loss. Such a terahertz (THz) interconnect will soon be required by the insatiable demand for higher speed devices and wider bandwidth communication. Starting with the early optoelectronic generation and detection of single-mode, subpicosecond electrical pulses on coplanar transmission lines, their complete characterization by THz time-domain spectroscopy (THz-TDS) is described. The consequent discovery of phase-coherent Cherenkov radiation in the form of an electromagnetic shock wave from these propagating electrical pulses is discussed together with its dominant role in the large measured propagation loss of these pulses. Various techniques to reduce this radiation are presented. The importance of dielectric materials characterization is explained and illustrated by THz-TDS measurements of high T/sub c/ substrates. Newly obtained THz waveguide results are presented and compared to the performance of coplanar transmission lines.
Effectiveness of denial of handgun purchase to persons believed to be at high risk for firearm violence.

OBJECTIVES The purpose of this study was to determine whether denial of handgun purchase is an effective violence prevention strategy. METHODS Individuals denied handgun purchase because of a prior felony conviction and handgun purchasers with a felony arrest at time of purchase were examined. RESULTS Relative to those denied purchase, handgun purchasers were found to be at greater risk for subsequent offenses involving a gun (relative risk [RR] = 1.21, 95% confidence interval [CI] = 1.08, 1.36) or violence (RR = 1.24, 95% CI = 1.11, 1.39), after adjustment for number of prepurchase weapon/violence charges. CONCLUSIONS Denial of handgun purchase to persons with a prior felony conviction may lower their rate of subsequent criminal activity.