Miracle-dz/UniFAR-FTUs huggingface dataset:
High voltage J-waves as a predictor of death in acute ST-Segment elevated myocardial infarction in hospital

Aims: Stratification of the risk of malignant arrhythmias in patients with coronary artery disease remains a challenge. This study evaluated the potential of high voltage J-waves in patients with acute ST-segment elevated myocardial infarction (STEMI) to predict the risk of malignant arrhythmias during hospitalization. Methods: A total of 128 consecutive STEMI patients with J-waves were enrolled within 48 h after the onset of the STEMI in this prospective study. The mean age was 62.97 ± 12.1 years, and 108 patients were male. Both 12-lead electrocardiograms (ECGs) and right-sided chest lead ECGs were recorded simultaneously within 10 min of admission to the hospital. Continuous ECG monitoring was administered from admission until discharge. Clinical characteristics and ECG parameters were compared between patients who survived and those who died during hospitalization. Results: Malignant ventricular arrhythmias (MVAs) were seen with J-waves more frequently in STEMI patients who subsequently died (P < 0.05). J-wave voltage, QTDc, Tp-e, and the Tp-e/QT ratio increased significantly in patients who died (P < 0.05). Multivariate logistic regression analysis revealed that J-wave voltage (odds ratio [OR], 89.09; 95% confidence interval [CI], 2.606-3045.108; P < 0.05) and MVAs (OR, 4.296; 95% CI, 1.348–13.693; P < 0.05) were associated with the occurrence of sudden death in patients with STEMI during hospitalization. Conclusions: High voltage J-waves are a potential ECG parameter for predicting sudden death in patients with STEMI during hospitalization.
Why Science Is Not Necessarily Self-Correcting

The ability to self-correct is considered a hallmark of science. However, self-correction does not always happen to scientific evidence by default. The trajectory of scientific credibility can fluctuate over time, both for defined scientific fields and for science at-large. History suggests that major catastrophes in scientific credibility are unfortunately possible and the argument that “it is obvious that progress is made” is weak. Careful evaluation of the current status of credibility of various scientific fields is important in order to understand any credibility deficits and how one could obtain and establish more trustworthy results. Efficient and unbiased replication mechanisms are essential for maintaining high levels of scientific credibility. Depending on the types of results obtained in the discovery and replication phases, there are different paradigms of research: optimal, self-correcting, false nonreplication, and perpetuated fallacy. In the absence of replication efforts, one is left with unconfirmed (genuine) discoveries and unchallenged fallacies. In several fields of investigation, including many areas of psychological science, perpetuated and unchallenged fallacies may comprise the majority of the circulating evidence. I catalogue a number of impediments to self-correction that have been empirically studied in psychological science. Finally, I discuss some proposed solutions to promote sound replication practices enhancing the credibility of scientific results as well as some potential disadvantages of each of them. Any deviation from the principle that seeking the truth has priority over any other goals may be seriously damaging to the self-correcting functions of science.
Qualitative analysis of patient responses to the ABCD FreeStyle Libre audit questionnaire

The Abbott FreeStyle Libre flash glucose monitoring system is a novel sensor‐based, factory‐calibrated device that allows individuals with diabetes to monitor their interstitial glucose levels, capture up to 8 hours of interstitial glucose data, and predict future changes in interstitial glucose by scanning a temporary implantable glucose sensor with a reader device or compatible mobile phone.
Robust and Invariant Phase Based Local Feature Matching

Any feature matching algorithm needs to be robust, producing few false positives but also needs to be invariant to changes in rotation, illumination and scale. Several improvements are proposed to a previously published Phase Correlation based algorithm, which operates on local disc areas, using the Log Polar Transform to sample the disc neighborhood and the FFT to obtain the phase. It will be shown that the matching can be done in the frequency domain directly, using the Chi-squared distance, instead of computing the cross power spectrum. Moreover, it will be shown how combining these methods yields an algorithm that sorts out a majority of the false positives. The need for a peak to sub lobe ratio computation in order to cope with sub pixel accuracy will be discussed as well as how the FFT of the periodic component can enhance the matching. The result is a robust local feature matcher that is able to cope with rotational, illumination and scale differences to a certain degree.
HIV-infected individuals who use alcohol and other drugs, and virologic suppression

ABSTRACT People living with HIV (PLWH) on antiretroviral therapy (ART) who use substances were examined to (a) describe those with virologic control and (b) determine which substance use-factors are associated with lack of virologic control. Participants were adult PLWH taking ART with either past 12-month DSM-IV substance dependence or past 30-day alcohol or illicit drug use. Substance use factors included number of DSM-IV alcohol or drug dependence criteria and past 30-day specific substance use. Associations with HIV viral load (HVL) (<200 vs. ≥200 copies/mL) were tested using logistic regression models. Multivariable analyses adjusted for age, sex, homelessness and anxiety or depression. Participants (n = 202) were median age 50 years, 66% male, 51% African American and 75% self-reported ≥90% past 30-day ART adherence. Though HVL suppression (HVL <200 copies/mL) was achieved in 78% (158/202), past 30-day substance use was common among this group: 77% cigarette use; 51% heavy alcohol use; 50% marijuana; 27% cocaine; 16% heroin; and 15% illicit prescription opioid use. After adjusting for covariates, specific substance use was not associated with a detectable HVL, however number of past 12-month DSM-IV drug dependence criteria was (adjusted odds ratio = 1.23 for each additional criterion, 95% CI: 1.04–1.46). Three-quarters of a substance-using cohort of PLWH receiving ART had virologic control and ≥90% ART adherence. Substance dependence criteria (particularly drug dependence), not specifically substance use, were associated with lack of virologic control. Optimal HIV outcomes can be achieved by individuals who use alcohol or drugs and addressing symptoms of substance dependence may improve HIV-related outcomes.
Expression of P2X receptors on rat microglial cells during early development

We have used single‐ and double‐labeling immunfluorescence and reverse transcription‐polymerase chain reaction (RT‐PCR) methods to examine expression of P2X receptor subtypes on microglial cells of brain in late embryonic and postnatal rat, in the N9 microglial cell line and primary cultured microglial cells. P2X1, P2X4, and P2X7 receptors were shown on microglial cells from late embryonic day 16. Almost all the microglial cells that were positive for the marker ED1, expressed P2X1 and P2X4 receptors, whereas only about 30% of the cells with ED1‐immunoreactivity were found to express the P2X7 receptor. Positive cells were localized mainly in the white matter and around ventricles. From postnatal day 7, many microglial cells with P2X4 receptor‐immunoreactivity were seen around the blood vessels. At postnatal day 30, microglial cells with P2X1 receptor‐immunoreactivity disappeared and the cells with P2X4 receptor‐immunoreactivity were mainly localized around blood vessels and lining the subarachnoid space. From postnatal day 30, the microglial cells with P2X7 receptor‐immunoreactivity were found to be distributed widely in the forebrain. Cells with P2X7 receptor‐immunoreactivity from P30 were not labeled by ED1, but some were labeled by isolectin B4. The expression of P2X1, P2X4, and P2X7 receptor mRNA and protein on primary cultures of rat microglial cells and on the N9 microglial cell line was demonstrated with immunocytochemistry and RT‐PCR. This is the first report that the P2X1 receptor is expressed on microglial cells, at least in early development, before postnatal day 30. © 2005 Wiley‐Liss, Inc.
Weighted Fuzzy Dempster–Shafer Framework for Multimodal Information Integration

This study proposes an architecture based on a weighted fuzzy Dempster–Shafer framework (WFDSF), which can adjust weights associated with inconsistent evidence obtained by different classification approaches, to realize a fusion system for integrating multimodal information. The Dempster–Shafer theory (D-S theory) of evidence enables us to integrate heterogeneous information from multiple sources to obtain collaborative inferences for a given problem. To conquer various uncertainties associated with the collected information, our system assigns beliefs and plausibilities to possible hypotheses of each decision maker and uses a combination rule to fuse multimodal information. For information fusion, an important step in D-S aggregation is to find an appropriate basic probability assignment scheme for allocating support to each possible hypothesis/class, which remains an arduous and unsolved problem. Here, we propose a mathematical structure to aggregate weighted evidence extracted from two different types of approaches: fuzzy Naïve Bayes and nearest mean classification rule. Further, an intuitionistic belief assignment is employed to address uncertainties between hypotheses/classes. Finally, 12 benchmark problems from the UCI machine learning repository for classification are employed to validate the proposed WFDSF-based scheme. In addition, an application of WFDSF to a practical brain–computer interface problem involving multimodal data fusion is demonstrated in this study. The experimental results show that the WFDSF is superior to several existing methods.
Tribbles homolog 3 expression in spermatogonial stem cells of rat testes

Tribbles are a family of signal‐regulating proteins shown to coordinate the action and the suppression of different pathways. Tribbles homolog 3 (Trib3), the best‐studied member of the mammalian tribble family, has a key function in determining cell fate when responding to environmental challenges. Trib3 effects are also modulated by its direct interaction with other signaling molecules. We found that Trib3 is highly expressed in the early development of rat testis, at just the time when the gonocytes resume proliferation to give rise to A spermatogonia. Immunofluorescence staining of cross‐sections of rat testis and cultured spermatogonial stem cells (SSCs) also confirmed that Trib3 is expressed in rat SSCs.
Cardiovascular risk factors in 2011 and secular trends since 2007: The Cardiovascular Risk in Young Finns Study

Aims: Cardiovascular risk factor levels in 2011 and 4-year changes between 2007 and 2011 were examined using data collected in follow-ups of the Cardiovascular Risk in Young Finns Study. Methods: The study population comprised 2063 Finnish adults aged 34–49 years (45% male). Lipid and blood pressure levels, glucose and anthropometry were measured and life style risk factors examined with questionnaires. Results: Mean total cholesterol level in 2011 was 5.19 mmol/l, low density lipoprotein (LDL)-cholesterol 3.27 mmol/l, high density lipoprotein (HDL)-cholesterol 1.33 mmol/l, and triglycerides 1.34 mmol/l. Using American Diabetes Association criteria, Type 2 diabetes (T2D) was observed in 4.1% and prediabetes (fasting glucose 5.6–6.9 mmol/l or glycated hemoglobin 5.7–6.4%) diagnosed for 33.8% of the participants. Significant changes (P < 0.05) between 2007 and 2011 included an increase in waist circumference (3.3%) in women. In both sexes, systolic (−3.0% in women, −4.0% in men) and diastolic (−3.0% in women, −3.3% in men) blood pressure and triglycerides (−3.4% in women, −6.5% in men) decreased during follow-up. Conclusions: Previously observed favorable trends in LDL-cholesterol levels have leveled off among a sample of young and middle-aged adults in Finland. Triglyceride and blood pressure levels have decreased. Over one-third of the study population had prediabetes and may be at increased risk for T2D.
Successful Management of Jejunal Perforation in Burkitt's Lymphoma: A Case Report

Burkitt's lymphoma (BL) is rare, rapidly growing, and highly aggressive. Urgent commencement of chemotherapy is vital to prevent complications and promote a favourable prognosis. Any factor causing a delay in the initiation of chemotherapy will affect prognosis significantly. Intestinal perforation is a well-known complication with devastating consequences. It inevitably leads to a delay in the initiation of chemotherapy. There are few reports in the literature that discuss this complication. Furthermore, there are no reports of patients that have survived intestinal perforation occurring prior to the commencement of chemotherapy. We present a case of a 55-year-old male who survived perforation of advanced sporadic BL of the jejunum occurring prior to the commencement of chemotherapy. Critical aspects of the patients care are discussed.
Effects of short term sacral nerve stimulation on anal and rectal function in patients with anal incontinence

BACKGROUND Some patients with faecal incontinence are not amenable to simple surgical sphincter repair, due to sphincter weakness in the absence of a structural defect. AIMS To evaluate the efficacy and possible mode of action of short term stimulation of sacral nerves in patients with faecal incontinence and a structurally intact external anal sphincter. PATIENTS Twelve patients with faecal incontinence for solid or liquid stool at least once per week. METHODS A stimulating electrode was placed (percutaneously in 10 patients, operatively in two) into the S3 or S4 foramen. The electrode was left in situ for a minimum of one week with chronic stimulation. RESULTS Evaluable results were obtained in nine patients, with early electrode displacement in the other three. Incontinence ceased in seven of nine patients and improved notably in one; one patient with previous imperforate anus and sacral agenesis had no symptomatic response. Stimulation seemed to enhance maximum squeeze pressure but did not alter resting pressure. The rectum became less sensitive to distension with no change in rectal compliance. Ambulatory studies showed a possible reduction in rectal contractile activity and diminished episodes of spontaneous anal relaxation. CONCLUSIONS Short term sacral nerve stimulation notably decreases episodes of faecal incontinence. The effect may be mediated via facilitation of striated sphincter muscle function, and via neuromodulation of sacral reflexes which regulate rectal sensitivity and contractility, and anal motility.
Differentiation of Trypsin-LikeEnzymes in Human Plasma

The arginine amidase and arginine esterase activity of human plasma is compared with that of trypsin, thrombin, plasmin, and kallikrein by using the homologous synthetic amino acid substrates, benzoyl arginine amide (BAA) and benzoyl arginine ethyl ester (BAEE). Hydrolyses of BAA and BAEE in plasma are distinguished by several features: pH optimum, heat stability, storage stability, effect of dilution, surface contact activation, streptokinase activation, inhibition by proteolytic enzyme inhibitor, and range of normal variation. The differential sensitivity of trypsin, throm. bin, plasmin, and kallikrein toward these substrates and the similarity in reaction characteristics of plasma-BAA and trypsin-BAA provide evidence that the arginine amidase activity of plasma represents trypsin, while the arginine esterase activity of plasma is nonspecific.
Integrated method for boundary delineation of agricultural fields in multispectral satellite images

Agricultural field boundary information is important in many agricultural management practices and remotely sensed imagery can present valuable, timely, information about land parcels. This paper presents a multispectral segmentation method for automated delineation of agricultural field boundaries in digital imagery. Edge information from a gradient edge detector is integrated with region growing, where the multispectral information from all selected image bands is utilized in both procedures. In this way, information from several spectral bands (and/or different dates) can be used for delineating field boundaries with different characteristics. This is particularly important for agricultural applications, where multidate information is necessary to differentiate between, for instance, crops at different phenological growing stages. The results show that Landsat TM images are easier to delineate than SPOT images due to lower spectral variance between adjacent pixels.
Filamentary extension of the mem-con theory of memristance and its application to titanium dioxide sol-gel memristors

Titanium dioxide sol-gel memristors have two different modes of operation, believed to be dependent on whether there is bulk memristance, i.e. memristance throughout the whole volume, or a filamentary memristance, i.e. memristance caused by the connection of conducting filaments. The mem-con theory of memristance is based on the drift of oxygen vacancies rather than that of conducting electrons and has been previously used to describe bulk memristance in several devices. Here, the mem-con theory is extended to model memristance caused by small filaments of low resistance titanium dioxide and it compares favorably to experimental results for filamentary memristance in sol-gel devices.
Neuronal Differentiation of Human Umbilical Cord Blood Neural Stem-Like Cell Line

The expanding population of neural stem/progenitor cells can be selected from human cord blood nonhematopoietic (CD34-negative) mononuclear fraction. Due to repeated expansion and selection of these cells we have established the first clonogenic, nonimmortalized human umbilical cord blood neural stem-like cell (HUCB-NSC) line. This line can be maintained at different stages of neural progenitor development by the presence of trophic factors, mitogens and neuromorphogens in culture media. Neurogenic potential of HUCB-NSC was established for serum-free and low-serum cultured cells. Commitment of HUCB-NSC by serum was shown to be important for the optimal response to the signals provided by surrounding environment in vitro. Enhanced neuronal differentiation induced by dBcAMP treatment was accompanied by expression of several functional proteins including glutamatergic, GABAergic, dopamine, serotonin and acetylcholine receptors, which was shown by microarray, immunocytochemistry and electrophysiology. Electrophysiological studies, whole-cell patch-clamp recordings, revealed in differentiated HUCB-NSC two types of voltage-sensitive and several ligand-gated currents typical for neuronal cells. The above HUCB-NSC characteristic conceivably implicates that cord blood-derived progenitors could be effectively differentiated into functional neuron-like cells in vitro.
A novel LDPC decoder for DVB-S2 IP

In this paper a programmable Forward Error Correction (FEC) IP for a DVB-S2 receiver is presented. It is composed of a Low-Density Parity Check (LDPC), a Bose-Chaudhuri-Hoquenghem (BCH) decoder, and pre- and postprocessing units. Special emphasis is put on LDPC decoding, since it accounts for the most complexity of the IP core by far.
Ocean Vector Winds Retrieval From C-Band Fully Polarimetric SAR Measurements

We present an efficient algorithm for retrieving the ocean-surface wind vector from C-band Radar Satellite RADARSAT-2 fully polarimetric synthetic aperture radar (SAR) measurements based upon the copolarized geophysical model function, i.e., CMOD5.N, and the cross-polarized ocean backscatter model, i.e., C-2PO. The analysis of fine quad-polarization mode single-look complex SAR data and collocated in situ moored buoy observations reveals that the polarimetric correlation coefficient between co- and cross-polarization channels has odd symmetry with respect to the wind direction. This characteristic is different from the feature that normalized radar cross sections for quad-polarization have even symmetry regarding the wind direction. We first use the C-2PO model to directly retrieve wind speeds without any external wind-direction and radar-incidence-angle inputs. Subsequently, the retrieved wind speeds, along with incidence angles and CMOD5.N, are employed to invert the wind direction, still with ambiguities. The odd-symmetry property is then applied to remove the wind direction ambiguities. Thus, it is shown that fully polarimetric SAR measurements provide complementary directional information for the ocean-surface wind fields. This method has the potential to improve wind vector retrievals from space.
Optimal Cognitive Distance and Absorptive Capacity

The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4 T cell immune responses by identifying compounds that block the interaction of CD4 and MHC, class II, gene products and a method of treatment which comprises administering such an identified compound. The compounds that inhibit undesired human CD4 T cell immune responses can be used to treat disease such as multiple sclerosis and to prevent graft rejection and graft versus host disease. More specifically, the application concerns compounds having molecular weights between about 1400 and 400 that mimic three portions of the human CD4 lymphocyte cell surface antigen. The portions are residues 29-35, the C-C' loop of the D1 domain; residues 317-323, the C-C' loop of the D4 domain; and residues 346-353, the CDR3 or FG ridge of the D4 domain of the CD4 molecule. Specific examples of such compounds include cyclic peptides and peptidomimetic.
An Oscillatory Network Model of Head Direction, Spatially Periodic Cells and Place Cells Using Locomotor Inputs

We propose a computational modeling approach that explains the formation of a range of spatial cells like head direction cells, grid cells, border cells and place cells which are believed to play a pivotal role in the spatial navigation of an animal. Most existing models insert special symmetry conditions in the models in order to obtain such symmetries in the outcome; our models do not require such symmetry assumptions. Our modeling approach is embodied in two models: a simple one (Model #1) and a more detailed version (Model #2). In Model #1, velocity input is presented to a layer of Head Direction cells, with no special topology requirements, the outputs of which are presented to a layer of Path Integration neurons. A variety of spatially periodic responses resembling grid cells, are obtained using the Principal Components of Path Integration layer. In Model #2, the input consists of the locomotor rhythms from the four legs of a virtual animal. These rhythms are integrated into the phases of a layer of oscillatory neurons, whose outputs drive a layer of Head Direction cells. The Head Direction cells in turn drive a layer of Path Integration neurons, which in turn project to two successive layers of Lateral Anti Hebbian Networks (LAHN). Cells in the first LAHN resemble grid cells (with both hexagonal and square gridness), and border cells. Cells in the second LAHN exhibit place cell behaviour and a new cell type known as corner cell. Both grid cells and place cells exhibit phase precession in 1D and 2D spaces. The models outline the neural hierarchy necessary to obtain the complete range of spatial cell responses found in the hippocampal system.