Miracle-dz/UniFAR-FTUs huggingface dataset:
Post-traumatic headaches correlate with migraine symptoms in youth with concussion

Objective The term “post-traumatic migraine” (PTM) has been used to describe post-traumatic headaches (PTHs) that have associated migraine features, but studies of this relationship are lacking. The objective of the present study was to determine whether PTH correlates strongly with migraine symptoms among youth with concussion. Methods Twenty-three symptoms were analyzed from a retrospective cohort of 1953 pediatric patients with concussion. A principal component analysis (PCA) with oblique Promax rotation was conducted to explore underlying symptom relationships in the full cohort and in subcohorts stratified by the presence (n = 414) or absence (n = 1526) of premorbid headache. Results The mean patient age was 14.1 years; 63% were male. Headache was the most common postconcussion symptom, acknowledged by 69.4% of patients. When considering the full cohort, the PCA demonstrated clustering of headache with photophobia, phonophobia, nausea, dizziness, and neck pain. Similar clustering was present among patients without premorbid headaches. Repeating the analysis in the patients with preconcussion headaches led to elimination of neck pain from the cluster. Conclusions PTH correlates strongly with other migraine symptoms among youth with concussion, regardless of premorbid headaches. This clustering of migraine symptoms supports the existence of PTM as a distinct clinical entity in some patients.
Population Sizing for Optimum Sampling with Genetic Algorithms: A Case Study of the Onemax Problem

An experimental and analytical investigation of sampling, which focused on the sizing of population for optimum performance, was performed using the OneMax problem. A fixed-size population and population sizes that vary according to the number of samples were considered in this study. For the case of varying population sizes, population sizing models that ensure proper decision making of the GA and a newly derived model that maximizes the ending generation were studied. A method that provides the optimum sample size is illustrated along with the new population sizing model. The results reveal that maximizing the ending generation of the GA was more successful in maximizing performance.
The landscape of DNA methylation-mediated regulation of long non-coding RNAs in breast cancer

Although systematic studies have identified a host of long non-coding RNAs (lncRNAs) which are involved in breast cancer, the knowledge about the methyla-tion-mediated dysregulation of those lncRNAs remains limited. Here, we integrated multi-omics data to analyze the methylated alteration of lncRNAs in breast invasive carcinoma (BRCA). We found that lncRNAs showed diverse methylation patterns on promoter regions in BRCA. LncRNAs were divided into two categories and four subcategories based on their promoter methylation patterns and expression levels be-tween tumor and normal samples. Through cis-regulatory analysis and gene ontology network, abnormally methylated lncRNAs were identified to be associated with can-cer regulation, proliferation or expression of transcription factors. Competing endog-enous RNA network and functional enrichment analysis of abnormally methylated lncRNAs showed that lncRNAs with different methylation patterns were involved in several hallmarks and KEGG pathways of cancers significantly. Finally, survival analysis based on mRNA modules in networks revealed that lncRNAs silenced by high methylation were associated with prognosis significantly in BRCA. This study enhances the understanding of aberrantly methylated patterns of lncRNAs and pro-vides a novel insight for identifying cancer biomarkers and potential therapeutic tar-gets in breast cancer.
Impaired Collateral Recruitment and Outward Remodeling in Experimental Diabetes

OBJECTIVE—In this study, the effect of chronic hyperglycemia on acute ligation-induced collateral vasodilation, on monocyte chemotaxis, and on structural outward remodeling of collaterals was investigated. RESEARCH DESIGN AND METHODS—Femoral artery ligation was performed 8 weeks after alloxan or saline treatment in New Zealand White rabbits. Angiography was performed directly, 1 and 3 weeks after ligation. These angiographic recordings were used to quantify number of collaterals, lumen, and blood volume index. Reactive hyperemia response was tested by intramuscular laser Doppler measurements. Subsequently, blood was sampled from the aorta for monocyte chemotaxis. RESULTS—Ligation resulted in markedly lower acute collateral vasodilation in diabetic compared with control rabbits. Also, hyperemic vasodilatory response to local ischemia was impaired in diabetic rabbits. This difference persisted at 1 and 3 weeks after ligation, with a lower number of visible collaterals. In addition, the collateral lumen was markedly lower in diabetic rabbits after the maturation phase. Likewise, a reduced blood volume index in the region of growing collaterals was observed in diabetic animals. The monocyte migration toward vascular endothelial growth factor-A and monocyte chemotactic protein-1 was strongly reduced in diabetic rabbits. CONCLUSIONS—This study demonstrates that chronic hyperglycemia negatively affects the different phases of arteriogenesis: 1) impaired shear induced vasodilatation; 2) impaired outward collateral growth, reflected in the number of collaterals and blood volume index; and 3) inhibition of monocyte chemotaxis. Impairments were most evident in the acute phase of arteriogenesis. Therapies aimed at restoring acute collateral recruitment, such as vasodilators, may be of interest to improve collateral function in diabetes.
Antiepileptic drugs in psychiatry

Identifying carotid occlusion patients at risk of stroke Although atherothrombotic occlusion of the internal carotid artery (ICA) can cause a devastating stroke, in many instances it is a benign event, causing only transient ischaemic attacks (TIAs), a minor stroke, or even no symptom at all. Despite optimal medical treatment, however, the subsequent risk of stroke in patients with symptomatic ICA occlusion is around 7% per year, with 6% ipsilateral. It would be important to be able to identify patients at high risk of subsequent stroke to implement appropriate prevention. Studies performed over the last two decades have provided strong evidence that haemodynamic factors play a major role in such risk. The association of focally decreased cerebral blood flow (CBF) and increased oxygen extraction fraction (OEF)—coined “misery perfusion”—was first …
A semi-classical study of the Casati–Prosen triangle map

We investigate the semi-classical properties of a two-parameter family of piece-wise linear maps on the torus known as the Casati–Prosen or triangle map. This map is weakly chaotic and has zero Lyapunov exponent. A correspondence between classical and quantum observables is established, leading to an appropriate statement regarding equidistribution of eigenfunctions in the semi-classical limit. We then give a full description of our numerical study of the eigenvalues and eigenvectors of this family of maps. For generic choices of parameters, the spectral and eigenfunction statistics are seen to follow the predictions of the random matrix theory conjecture.
Unique Aspects of Content Unique Aspects of Software

ID Fellows Board Review Unique Aspects of Content The database is unique in that it provides detailed information on alternative therapy when the drug of choice cannot be given including drug allergy or intolerance, immunocompromised host, pregnancy, etc. Expanded summaries on microbiology, epidemiology, laboratory diagnosis, clinical manifestations and pathogenesis complement the comprehensive sections on antimicrobial therapy. Links are made to review articles in pharmacology and in vitro/animal studies. State-of-the-art updates from clinical peer-review journals are linked to individual topics. Historical vignettes giving anecdotes and historical perspective of key discoveries in microbiology and infectious diseases are included. Over 500 international authorities in infectious diseases, epidemiology and pharmacology contributed to this massive data base.
Comparison of methods for hand gesture recognition based on Dynamic Time Warping algorithm

Gesture recognition may find applications in rehabilitation systems, sign language translation or smart environments. The aim of nowadays science is to improve the recognition systems' efficiency but also to allow the user to perform the gesture in a natural way. The article presents different methods (DTW - Dynamic Time Warping, DDTW - Derivative Dynamic Time Warping, PDTW - Piecewise Dynamic Time Warping) based on Dynamic Time Warping algorithm, which is commonly used for hand gesture recognition using small wearable three-axial inertial sensor. Additionally, different approaches to signal definitions and preprocessing are discussed and tested. To verify which of the methods presented is more accurate in case of gesture recognition, database of 2160 simple gestures was collected, and recognition procedure was implemented. The main goal was to compare the efficiency of each method assuming that each person should perform the movement naturally. Obtained results suggest that the most efficient method for the presented problem was the DDTW. The worst recognition performance was achieved with the PDTW method.
Impact of surface treatment on the mechanical properties of sisal and jute reinforced with epoxy resin natural fiber hybrid composites

ABSTRACT Natural fiber composites (NFCs) are gaining importance in various fields of engineering due to their ecofriendly nature and low cost. The present work is aimed in studying the mechanical properties such as tensile strength, flexural strength, impact strength, and hardness for natural fiber/epoxy resin composites reinforced with sisal and jute. The composites are prepared by hand lay-up method by varying the proportion of jute fiber. One set of fibers is surface treated with NAOH solution and its impact on mechanical strength was studied. From the results obtained, it was observed that the tensile strength increases by 20%, flexural strength by 25%, impact strength increases by 27.27%, and hardness by 5% for surface treated composites. Scanning electron microscope was used to study the morphology of prepared specimen and fractured specimen. The results indicate that surface-treated composites perform better than the untreated fiber composites.
Maintenance Pharmacotherapy for Opioid Dependence and SF-36 Health Status: A Comparison With General Population Norms and Other Chronic Disorders

ObjectivesTo assess the health status of heroin users starting and following 3 months of pharmacotherapy for opioid dependence, and to compare outcomes to a range of other chronic medical illnesses treated with maintenance medication. MethodsThe study uses pooled data from 6 clinical trials included in an Australian National Evaluation of Pharmacotherapies for Opioid Dependence. Participants received maintenance pharmacotherapy (oral naltrexone treatment, methadone, or buprenorphine) for the treatment of heroin dependence. Participants' health status was measured using the Short Form 36 health survey completed before treatment and at 3-month follow-up. Baseline data from 326 heroin-dependent participants starting maintenance treatment, and 3-month follow-up data for the 117 participants retained in trial treatment are presented. ResultsHeroin users at entry into pharmacotherapy for opioid dependence were in very poor psychological and physical health in relation to Australian population norms. For the 117 participants retained in treatment, clinically and statistically significant improvements in physical health, and emotional and social health were observed in just 3 months. Importantly, the health status of treated heroin users improves to a comparable or greater degree than that observed with other chronic illnesses treated with maintenance medication. ConclusionsExisting, evidence-based pharmacotherapies should be used in the treatment of heroin dependence with the same long-term care and medical monitoring strategies currently used in the treatment of other chronic illnesses.
Ultrasonic defect detection in wooden pallet parts for quality sorting

Millions of wooden pallets are discarded annually due to damage or because their low cost makes them readily disposable. Higher quality wooden pallets, however, can be built from high quality deckboards and stringers, and have a much longer life cycle and a lower cost per trip. The long- term goal of this project is to develop an automated pallet part inspection system to sort pallet parts according to grade. Ultrasonic time of flight (TOF) measurements in a pitch-catch arrangement are being used to distinguish types of defects, including knots, decay, cross grain, and voids, from clear wood. Rolling transducers of 3 different frequencies have been used to collect measurements on four oak deckboards of 1/2 inch thickness. Ultrasonic C-scans taken on a 1/2 inch by 1/2 inch grid indicate that TOF with 84 KHz transducers can be used to partially distinguish between several deckboard features and clear wood. Nevertheless, future application of these results to defect detection must not be limited to single, pixel value classification, but must include pixel neighborhoods with textural information.
Molecular Dynamics Simulation of Biomembrane Systems

The fundamental structure of all biological membranes is the lipid bilayer. Attributed to the multifaceted features of lipids and its dynamical interaction with other membrane-integrated molecules, the lipid bilayer is involved in a variety of physiological phenomena such as transmembrane transportation, cellular signalling transduction, energy storage, etc. Due to the nanoscale but high complexity of the lipid bilayer system, experimental investigation into many important processes at the molecular level is still challenging. Molecular dynamics (MD) simulation has been emerging as a powerful tool to study the lipid membrane at the nanoscale. Utilizing atomistic MD, we have quantitatively investigated the effect of lamellar and nonlamellar lipid composition changes on a series of important bilayer properties, and how membranes behave when exposed to a high-pressure environment. A series of membrane properties such as lateral pressure and dipole potential profiles are quantified. Results suggest the hypothesis that compositional changes, involving both lipid heads and tails, modulate crucial mechanical and electrical features of the lipid bilayer, so that a range of biological phenomena, such as the permeation through the membrane and conformational equilibria of membrane proteins, may be regulated. Furthermore, water also plays an essential role in the biomembrane system. To balance accuracy and efficiency in simulations, a coarse-grained ELBA water model was developed. Here, the ELBA water model is stress tested in terms of temperatureand pressure-related properties, as well as hydrating properties. Results show that the accuracy of the ELBA model is almost as good as conventional atomistic water models, while the computational efficiency is increased substantially.
The efficiency of using advanced PRF-xenograft mixture around immediate implants in the esthetic zone: a randomized controlled clinical trial

Aim Immediate implant placement in fresh extraction sockets is an accepted treatment modality and for better predictable outcomes the resultant peri-implant gap should be grafted. Many grafting materials are available; in this study, a xenograft was used with Advanced-Platelet-Rich Fibrin (A-PRF) as a supplement to tissue regeneration procedures. The aim of this study was to evaluate clinically and radiographically the efficiency of using A-PRF-xenograft mixture around immediate implants in the esthetic zone. Materials and methods For this randomized controlled clinical trial, 18 patients requiring extraction of maxillary anterior teeth and immediate implant placement were selected. They were randomly divided into two groups: the study group, where the peri-implant gap was filled with A-PRF-xenograft mixture, and the control group, where the gap was filled with xenograft alone. The variables studied were probing depth, implant stability, marginal bone height and bone density; the follow-up period was 9 months. For statistical analysis, independent and paired t-tests were used. Results Improvements were seen regarding all variables with no significant differences noticed during follow-up, except for implant stability which showed statistically significant differences. Conclusion The results highlighted the promising effects of A-PRF-xenograft mixture on bone and soft tissue healing around immediate implants in the esthetic zone.
Caspase-Dependent and Caspase-Independent Pathways Are Involved in Cadmium-Induced Apoptosis in Primary Rat Proximal Tubular Cell Culture

We designed this study to investigate whether cadmium induces caspase-independent apoptosis and to investigate the relationship between the caspase-dependent and caspase-independent apoptotic pathways. Cadmium (1.25–2.5 μM) induced oxidative stress in rat proximal tubular (rPT) cells, as seen in the reactive oxygen species levels; N-acetylcysteine prevented this. Cyclosporin A (CsA) prevented mitochondrial permeability transition pore opening and apoptosis; there was mitochondrial ultrastructural disruption, mitochondrial cytochrome c (cyt c) translocation to the cytoplasm, and subsequent caspase-9 and caspase-3 activation. Z-VAD-FMK prevented caspase-3 activation and apoptosis and decreased BNIP-3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) expression levels and apoptosis-inducing factor/endonuclease G (AIF/Endo G) translocation. Simultaneously, cadmium induced prominent BNIP-3 expression in the mitochondria and cytoplasmic AIF/Endo G translocation to the nucleus. BNIP-3 silencing significantly prevented AIF and Endo G translocation and decreased the apoptosis rate, cyt c release, and caspase-9 and caspase-3 activation. These results suggest that BNIP-3 is involved in the caspase-independent apoptotic pathway and is located upstream of AIF/Endo G; both the caspase-dependent and caspase-independent pathways are involved in cadmium-induced rPT cell apoptosis and act synergistically.
Physiological changes in certain test plants under automobile exhaust pollution.

Plants are the only living organisms which have to suffer a lot from automobile exhaust pollution because they remain static at their habitat. But such roadside plants like Nerium indicum Mill. , Boerhaavia diffusa L. , Amaranthus spinosus L. , Cephalandra indica Naud. , and Tabemaemontana divaricata L. can easily avoid the effects of air pollution by altering their physiological pathways pertaining to photosynthesis and respiration. Stomatal closure in Boerhaavia, Amaranthus, Cephlandra and stomatal clogging in Nerium and Tabemaemontana help these plants in preventing the entry of poisonous gases. The increased activity of the enzyme Phosphoenol Pyruvate Carboxylase (PEPCase) belonging to C4 pathway helps Nerium and Boerhaavia (both C3 plants) in carbon fixation under stress condition. Photorespiration is favoured in Amaranthus, Cephalandra and Tabernaemontana to compensate for the over production of ATP in them. Owing an inefficient gaseous exchange in Boerhaavia and Tabemaemontana, the activity of Glucose 6--Phosphate Dehydrogenase (G6-PD) also increases for the preferential shift to Pentose Phosphate Pathway to produce excess NADPH+H+ which are likely to re-oxidize by metabolic reactions not linked to electron transport chain.
The Parameter to Characterize Chaotic Dynamics

In this work, an asymptotic measure is introduced in order to characterize chaotic dynamics. This is the asymptotic distance between trajectories \math, which can actually help either as a complementary measure to Lyapunov exponents, or as an alternative parameter characterizing chaos when Lyapunov exponents are either very difficult, or impossible to work out. Some analytical relationships between the leading Lyapunov exponent and the values of \math both for discrete maps and continuous systems are here reported, together with experimental comparisons drawn from the simulation of Chua's circuit in different operational conditions.
Photosynthetic action spectra and adaptation to spectral light distribution in a benthic cyanobacterial mat

We studied adaptation to spectral light distribution in undisturbed benthic communities of cyanobacterial mats growing in hypersaline ponds at Guerrero Negro, Baja California, Mexico. Microscale measurements of oxygen photosynthesis and action spectra were performed with microelectrodes; spectral radiance was measured with fiber-optic microprobes. The spatial resolution of all measurements was 0.1 mm, and the spectral resolution was 10 to 15 nm. Light attenuation spectra showed absorption predominantly by chlorophyll a (Chl a) (430 and 670 nm), phycocyanin (620 nm), and carotenoids (440 to 500 nm). Blue light (450 nm) was attenuated 10-fold more strongly than red light (600 nm). The action spectra of the surface film of diatoms accordingly showed activity over the whole spectrum, with maxima for Chl a and carotenoids. The underlying dense Microcoleus population showed almost exclusively activity dependent upon light harvesting by phycobilins at 550 to 660 nm. Maximum activity was at 580 and 650 nm, indicating absorption by phycoerythrin and phycocyanin as well as by allophycocyanin. Very little Chl a-dependent activity could be detected in the cyanobacterial action spectrum, even with additional 600-nm light to excite photosystem II. The depth distribution of photosynthesis showed detectable activity down to a depth of 0.8 to 2.5 mm, where the downwelling radiant flux at 600 nm was reduced to 0.2 to 0.6% of the surface flux.
More than Zero Intelligence Needed for Continuous Double-Auction Trading

Gode & Sunder's (1993) results from using \zerointelligence" (zi) traders, that act randomly within a continuous double-auction (cda) market, appear to imply that human-like convergence to the theoretical equilibrium price in such markets is determined more by market structure than by the intelligence of the traders in that market. This paper presents a mathematical analysis that predicts serious failures in zi-trader cda markets. The analytical predictions are con rmed by computer simulations. Thus, more than zero intelligence is required of trading agents to yield humanlike cda market behavior.
Numerical Thermal Model of Diode Double-End-Pumped Solid State Lasers

In this work, a numerical analysis based on finite element method (FEM) has been used to predict both the temperature distribution and focal length in CW Nd:YAG laser rod. The double end-pumped utilizing two different pumping profiles, namely, Gaussian and superGaussian beam profiles are adopted in this simulation. In addition, four different superGaussian beam profiles (N = 4, 6, 10, 30) have been studied and compared with the Gaussian (N = 2) pump profile. At Gaussian pumping power of 40 W (20 W for each face), maximum center temperature is observed for each face of the two end-pumped faces were found, and start to decrease in the super-Gaussian case as the exponent factor N increases. The thermal lensing effect strongly depends on different factors, namely, power of the pump source, and distribution profile of the pump through the laser medium geometry. Therefore, the double-end-pumped method may be considered as important to reduce temperature gradiant in the laser rod while choosing the type of pumping profiles.