Miracle-dz/UniFAR-FTUs huggingface dataset:
An H7N1 Influenza Virus Vaccine Induces Broadly Reactive Antibody Responses against H7N9 in Humans

ABSTRACT Emerging H7N9 influenza virus infections in Asia have once more spurred the development of effective prepandemic H7 vaccines. However, many vaccines based on avian influenza viruses—including H7—are poorly immunogenic, as measured by traditional correlates of protection. Here we reevaluated sera from an H7N1 human vaccine trial performed in 2006. We examined cross-reactive antibody responses to divergent H7 strains, including H7N9, dissected the antibody response into head- and stalk-reactive antibodies, and tested the in vivo potency of these human sera in a passive-transfer H7N9 challenge experiment with mice. Although only a low percentage of vaccinees induced neutralizing antibody responses against the homologous vaccine strain and also H7N9, we detected strong cross-reactivity to divergent H7 hemagglutinins (HAs) in a large proportion of the cohort with a quantitative enzyme-linked immunosorbent assay. Furthermore, H7N1 vaccination induced antibodies to both the head and stalk domains of the HA, which is in sharp contrast to seasonal inactivated vaccines. Finally, we were able to show that both neutralizing and nonneutralizing antibodies improved in vivo virus clearance in a passive-transfer H7N9 challenge mouse model.
Radio-Frequency Coils in Implantable Devices: Misalignment Analysis and Design Procedure

Radio-frequency (RF) coils are used extensively in the design of implantable devices for transdermal power and data transmission. The practical issues of coil misalignments and configurations have not been investigated, and this paper presents a detailed theoretical analysis of misalignment effects in RF coil systems, including lateral and angular misalignments. Formulas are derived for the mutual inductance and, whenever possible, simplified upper bounds and lower bounds of the coupling coefficient are provided. A design procedure is established to maximize coil coupling for a given configuration, and a companion paper [1] discusses a circuit design technique to reduce the effects of misalignment on transmission efficiency.
Robotic Tactile Sensor System and Applications

This paper presents a tactile sensor system for a robot manipulator and an active-sensing technique to realize 3-D object recognitions concerning object shape, object surface normal, and object edge tracing with experimental results. The proposed tactile sensor units implemented on the robot hand consist of three thin sheets of force-sensitive resistors arranged triangularly with the peripheral circuits. One potential application of the proposed techniques is to realize an effective human-robot cooperation to move an object together by utilizing the control of a hand pose to keep the direction of the hand normal to the object surface in three dimensions, which is often necessary when pushing an object. Another is a 3-D object edge tracing. The proposed techniques can be employed in industrial processes such as welding and inspection to eliminate manual teaching procedures for searching the object edge automatically before doing the welding process. In these applications, information about the object shape or orientation is not required in advance.
A robust biologically plausible implementation of ICA-like learning

We present a model that can perform ICA-like learning by simple, local, biologically plausible rules. By combining synaptic learning with homeostatic regulation of neuron properties and adaptive lateral in- hibition, the neural network can robustly learn Gabor-like receptive fields from natural images. With spatially localized inhibitory connections, a topographic map can be achieved. Additionally, the network can solve the Foldiak bars problem, a classical nonlinear ICA task.
Formation control of multi-agent systems with heterogeneous communication delays

In this article, the formation control is investigated for a network of second-order dynamic agents with heterogeneous communication delays. The desired stationary formation is achieved by introducing diverse self-delay for each agent. In addition, a delay-dependent formation control algorithm is proposed to achieve the desired moving formation. Based on the frequency-domain analysis and matrix theory, sufficient conditions are obtained for the multi-agent systems asymptotically converging to desired stationary and moving formations, respectively. Simulation results illustrate the correctness of the results.
Fast copy coalescing and live-range identification

This paper presents a fast new algorithm for modeling and reasoning about interferences for variables in a program without constructing an interference graph. It then describes how to use this information to minimize copy insertion for &fgr;-node instantiation during the conversion of the static single assignment (SSA) form into the control-flow graph (CFG), effectively yielding a new, very fast copy coalescing and live-range identification algorithm.This paper proves some properties of the SSA form that enable construction of data structures to compute interference information for variables that are considered for folding. The asymptotic complexity of our SSA-to-CFG conversion algorithm is where-is the number of instructions in the program.Performing copy folding during the SSA-to-CFG conversion eliminates the need for a separate coalescing phase while simplifying the intermediate code. This may make graph-coloring register allocation more practical in just in time (JIT) and other time-critical compilers For example, Sun's Hotspot Server Compiler already employs a graph-coloring register allocator[10]. This paper also presents an improvement to the classical interference-graph based coalescing optimization that shows adecrease in memory usage of up to three orders of magnitude and a decrease of a factor of two in compilation time, while providing the exact same results.We present experimental results that demonstrate that our algorithm is almost as precise (within one percent on average) as the improved interference-graph-based coalescing algorithm, while requiring three times less compilation time.
Novel Application of Fluorescence Lifetime and Fluorescence Microscopy Enables Quantitative Access to Subcellular Dynamics in Plant Cells

Background Optical and spectroscopic technologies working at subcellular resolution with quantitative output are required for a deeper understanding of molecular processes and mechanisms in living cells. Such technologies are prerequisite for the realisation of predictive biology at cellular and subcellular level. However, although established in the physical sciences, these techniques are rarely applied to cell biology in the plant sciences. Principal Findings Here, we present a combined application of one-chromophore fluorescence lifetime microscopy and wavelength-selective fluorescence microscopy to analyse the function of a GFP fusion of the Brassinosteroid Insensitive 1 Receptor (BRI1-GFP) with high spatial and temporal resolution in living Arabidopsis cells in their tissue environment. We show a rapid, brassinolide-induced cell wall expansion and a fast BR-regulated change in the BRI1-GFP fluorescence lifetime in the plasmamembrane in vivo. Both cell wall expansion and changes in fluorescence lifetime reflect early BR-induced and BRI1-dependent physiological or signalling processes. Our experiments also show the potential of one-chromophore fluorescence lifetime microscopy for the in vivo monitoring of the biochemical and biophysical subcellular environment using GFP fusion proteins as probes. Significance One-chromophore fluorescence lifetime microscopy, combined with wavelength-specific fluorescence microscopy, opens up new frontiers for in vivo dynamic and quantitative analysis of cellular processes at high resolution which are not addressable by pure imaging technologies or transmission electron microscopy.
Primary care emergency team training in situ means learning in real context

Abstract Objective: The purpose of our study was to explore the local learning processes and to improve in situ team training in the primary care emergency teams with a focus on interaction. Design, setting and subjects: As participating observers, we investigated locally organised trainings of teams constituted ad hoc, involving nurses, paramedics and general practitioners, in rural Norway. Subsequently, we facilitated focus discussions with local participants. We investigated what kinds of issues the participants chose to elaborate in these learning situations, why they did so, and whether and how local conditions improved during the course of three and a half years. In addition, we applied learning theories to explore and challenge our own and the local participants’ understanding of team training. Results: In situ team training was experienced as challenging, engaging, and enabling. In the training sessions and later focus groups, the participants discussed a wide range of topics constitutive for learning in a sociocultural perspective, and topics constitutive for patient safety culture. The participants expanded the types of training sites, themes and the structures for participation, improved their understanding of communication and developed local procedures. The flexible structure of the model mirrors the complexity of medicine and provides space for the participants’ own sense of responsibility. Conclusion: Challenging, monthly in situ team trainings organised by local health personnel facilitate many types of learning. The flexible training model provides space for the participants’ own sense of responsibility and priorities. Outcomes involve social and structural improvements, including a sustainable culture of patient safety. KEY POINTS Challenging, monthly in situ team trainings, organised by local health personnel, facilitate many types of learning. The flexible structure of the training model mirrors the complexity of medicine and the realism of the simulation sessions. Providing room for the participants’ own priorities and sense of responsibility allows for improvement on several levels. The participants demonstrated a consistent, long-term motivation to strengthen safety, both for their patients and for themselves.
Evaluation of Angiotensin Converting Enzyme (ACE)-Like Activity of Acellular Hemoglobin

Despite the tremendous progress in research on hemoglobin (Hb) cellular and molecular responses, the current understanding of Hb's overall intrinsic toxicity is still limited. The complete mechanism of Hb-induced vasoconstriction has not yet been established, particularly the involvement of the renin-angiotensin system (RAS). Some studies emphasized that Hb may augment the vascular responsiveness to angiotensin (Ang)-II. It was also reported that Hb, as well as Ang-II, influences the synthesis of 8-iso prostaglandin F2 alpha, which has an impact on renal flow and possibly RAS. Hb in the presence of H2O2 gains enzymatic activity. Thus, it is possible that Hb directly and/or indirectly can activate RAS. In this study, we monitored the effect of ferrous- and ferryl-Hb, and H2O2 alone, on conversion of Ang-I to its active metabolites. The structural and immunological identity of the resulting products were evaluated by reversed phase C-18 HPLC and ELISA, respectively. Additionally, ACE-like activity of Hbs was measured spectrophotometrically by determining their ability to react with the ACE substrate, the synthetic tripeptide N-[3-(2-furyl)acryloyl]-L-phenylalanylglycylglycine. Results indicate that while ferrous-Hb can serve as a receptor for Ang-I, its ferryl form possesses ACE-like activity, being able to convert, within minutes, Ang-I to Ang-II, Ang-III, Ang-IV, Ang (1-7) and other unresolved fragments. H2O2 itself had a very limited hydrolyzing effect on Ang-I. Based on this study, it can be concluded that ACE-like activity of Hb with rapid formation of active angiotensins may be a contributor to the still unexplained vasoconstrictive response observed immediately after Hb administration.
A Simple Model of Cortical Dynamics Explains Variability and State Dependence of Sensory Responses in Urethane-Anesthetized Auditory Cortex

The responses of neocortical cells to sensory stimuli are variable and state dependent. It has been hypothesized that intrinsic cortical dynamics play an important role in trial-to-trial variability; the precise nature of this dependence, however, is poorly understood. We show here that in auditory cortex of urethane-anesthetized rats, population responses to click stimuli can be quantitatively predicted on a trial-by-trial basis by a simple dynamical system model estimated from spontaneous activity immediately preceding stimulus presentation. Changes in cortical state correspond consistently to changes in model dynamics, reflecting a nonlinear, self-exciting system in synchronized states and an approximately linear system in desynchronized states. We propose that the complex and state-dependent pattern of trial-to-trial variability can be explained by a simple principle: sensory responses are shaped by the same intrinsic dynamics that govern ongoing spontaneous activity.
Engineering Properties of stabilised tropical peat soils

Peaty soils are not suitable as foundation soils as they are weak and highly compressible. This paper describes a study on peat soil stabilisation to improve its physical and engineering properties. It investigates the effect of additives (binder amount 5, 10 and 15 (85cement, 15 bentonite) and range of sand 5 to 25 on the index properties as well as, pH, compaction, California Bearing Ratio and unconfined compressive strength of tropical peat soils. The amount of additives added to the peat soil sample was investigated in terms of the percentage of the dry soil mass. The results showed that of the additive admixtures altered the engineering properties of tropical peat soils. The soil liquid limit was found to decrease with increase of the additive content. The pH was found to increase with increase binder. The maximum dry density was found to increase while the optimum moisture content was found to decrease with the increase of the additive content. The California Bearing Ratio of the soil was found to increase significantly with increase in the additives.
Biconnectivity, chain decomposition and $st$-numbering using $O(n)$ bits

Recent work by Elmasry et al. (STACS 2015) and Asano et al. (ISAAC 2014) reconsidered classical fundamental graph algorithms focusing on improving the space complexity. Elmasry et al. gave, among others, an implementation of depth first search (DFS) of a graph on n vertices and m edges, taking O(m lg lg n) time using O(n) bits of space improving on the time bound of O(m lg n) due to Asano et al. Subsequently Banerjee et al. (COCOON 2016) gave an O(m + n) time implementation using O(m+n) bits, for DFS and its classical applications (including testing for biconnectivity, and finding cut vertices and cut edges). Recently, Kammer et al. (MFCS 2016) gave an algorithm for testing biconnectivity using O(n + min{m, n lg lg n}) bits in linear time. In this paper, we consider O(n) bits implementations of the classical applications of DFS. These include the problem of finding cut vertices, and biconnected components, chain decomposition and st-numbering. Classical algorithms for them typically use DFS and some Omega(lg n) bits of information at each node. Our O(n)-bit implementations for these problems take O(m lg^c n lg lg n) time for some small constant c (c leq 3). Central to our implementation is a succinct representation of the DFS tree and a space efficient partitioning of the DFS tree into connected subtrees, which maybe of independent interest for space efficient graph algorithms.
An efficient multi-gateway-based three-factor user authentication and key agreement scheme in hierarchical wireless sensor networks

User authentication in wireless sensor network WSN plays a very important role in which a legal registered user is allowed to access the real-time sensing information from the sensor nodes inside WSN. To allow such access, a user needs to be authenticated by the accessed sensor nodes as well as gateway nodes inside WSNs. Because of resource limitations and vulnerability to physical capture of some sensor nodes by an attacker, design of a secure user authentication in WSN continues to be an important and challenging research area in recent years. In this paper, we propose a new three-factor user authentication scheme based on the multi-gateway WSN architecture. Through the widely-accepted Burrows-Abadi-Needham logic, we prove that our scheme provides the secure mutual authentication. We then present the formal security verification of our proposed scheme using AVISPA tool, which is a powerful validation tool for network security applications, and show that our scheme is secure. In addition, the rigorous informal security analysis shows that our scheme is also secure against possible other known attacks including the sensor node capture attack. Furthermore, we present the additional functionality features that our scheme offers, which are efficient in communication and computation. Copyright © 2016 John Wiley & Sons, Ltd.
A remarkable short-snouted horned dinosaur from the Late Cretaceous (late Campanian) of southern Laramidia

The fossil record of centrosaurine ceratopsids is largely restricted to the northern region of western North America (Alberta, Montana and Alaska). Exceptions consist of single taxa from Utah (Diabloceratops) and China (Sinoceratops), plus otherwise fragmentary remains from the southern Western Interior of North America. Here, we describe a remarkable new taxon, Nasutoceratops titusi n. gen. et sp. , from the late Campanian Kaiparowits Formation of Utah, represented by multiple specimens, including a nearly complete skull and partial postcranial skeleton. Autapomorphies include an enlarged narial region, pneumatic nasal ornamentation, abbreviated snout and elongate, rostrolaterally directed supraorbital horncores. The subrectangular parietosquamosal frill is relatively unadorned and broadest in the mid-region. A phylogenetic analysis indicates that Nasutoceratops is the sister taxon to Avaceratops, and that a previously unknown subclade of centrosaurines branched off early in the group's history and persisted for several million years during the late Campanian. As the first well-represented southern centrosaurine comparable in age to the bulk of northern forms, Nasutoceratops provides strong support for the provincialism hypothesis, which posits that Laramidia—the western landmass formed by inundation of the central region of North America by the Western Interior Seaway—hosted at least two coeval dinosaur communities for over a million years of late Campanian time.
Acoustic Fresnel lenses with extraordinary transmission

We investigate numerically and experimentally highly efficient acoustic lenses based on the principle of extraordinary acoustic transmission. We study circular, flat lenses composed of perforated air channels. The geometry is similar to binary Fresnel lenses, and the lenses exploit several resonance mechanisms to enhance the transmission, such as Fabry–Perot resonances in the channels and cavity resonances on the lens surface. The proposed lenses are able to transmit up to 83% of the incident energy and generate sharp focusing with very high amplification (up to 16 dB experimentally). Furthermore, the resulting lenses are thinner than other designs providing similar performance, making them ideal candidates for application in acoustic imaging and medical diagnostics.
Immunohistochemical analysis of ZAP‐70 expression in B‐cell lymphoid neoplasms

ZAP‐70 is a tyrosine kinase that participates in early B‐cell differentiation and is a prognostic factor in chronic lymphocytic leukaemia (CLL), where it is associated with an unmutated configuration of the IgVH genes. In this study ZAP‐70 expression was studied by immunohistochemistry in a spectrum of B‐cell lymphoid neoplasms; this staining method was compared with flow cytometry, and the relationship of ZAP‐70 expression to mutational status and prognosis was assessed. 242 tissue samples from 225 patients with B‐cell lymphoid neoplasms arising at different maturational stages were included. Flow cytometry was performed in all CLL cases (n = 52). IgVH mutational status was determined in 25 CLL and 12 mantle cell lymphoma (MCL) patients. ZAP‐70 was positive in 34/52 (65%) CLL, 9/31 (31%) Burkitt's lymphoma, 2/7 (29%) lymphoblastic lymphomas, 3/36 (8%) MCL, 1/23 (4%) marginal zone lymphoma, and 1/45 (2%) diffuse large B‐cell lymphomas, but in none of the 19 follicular lymphomas or the 14 Hodgkin lymphomas. An identical ZAP‐70 pattern was obtained in six patients with simultaneous biopsies from different sites and in 12 patients with sequential biopsies. Immunohistochemistry and flow cytometry gave identical results in 48 the 52 CLLs. All but one ZAP‐70‐positive CLL had IgVH gene in an unmutated configuration, whereas all but one ZAP‐70‐negative CLL had somatically hypermutated IgVH. The 12 MCLs analysed were ZAP‐70 negative regardless of IgVH mutational status (4 mutated, 8 unmutated). ZAP‐70 positive CLL was associated with a shorter overall survival (median time 103 months vs. 293 months, p = 0.01) and a shorter time to disease progression (median time 26 months vs. 60 months, p = 0.01). In conclusion, ZAP‐70 is expressed in several types of B‐cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with CLL from whom no other material is available or when other techniques for its assessment cannot be performed. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
An integrated physiological and performance profile of professional tennis

Objective: To describe the physiological responses to tournament tennis in relation to prevailing environmental conditions, match notation, and skills that underpin performance. Design: 14 male professional tennis players (mean (SD) age, 21.4 (2.6) years; height, 183.0 (6.9) cm; body mass, 79.2 (6.4) kg) were studied while contesting international tennis tournaments. Environmental conditions, match notation, physiological (core temperature, hydration status, heart rate, blood variables), and performance indices (serve kinematics, serve velocity, error rates) were recorded. Results: Hard and clay court tournaments elicited similar peak core temperature (38.9 (0.3) v 38.5 (0.6)°C) and average heart rate (152 (15) v 146 (19) beats/min) but different body mass deficit (1.05 (0.49) v 0.32 (0.56)%, p<0.05). Average pre-match urine specific gravity was 1.022 (0.004). Time between points was longer during hard court matches (25.1 (4.3) v 17.2 (3.3) s, p<0.05). Qualitative analysis of first and second serves revealed inverse relations between the position of the tossing arm at ball release and the position of the ball toss and progressive match time (respectively, r = −0.74 and r = −0.73, p<0.05) and incurred body mass deficit (r = 0.73 and r = 0.73, p<0.05). Conclusions: Participants began matches in a poor state of hydration, and experienced moderate thermoregulatory strain and dehydration during competition. These adverse physiological conditions may compromise performance and influence notational analyses.