Miracle-dz/UniFAR-FTUs huggingface dataset:
Elsevier Editorial System(tm) for Neuroimage Manuscript Draft Title: Validation of Ica-based Myogenic Artifact Correction for Scalp and Source-localized Eeg

Muscle electrical activity, or "electromyogenic" (EMG) artifact, poses a serious threat to the validity of electroencephalography (EEG) investigations in the frequency-domain. EMG is sensitive to a variety of psychological processes and can mask genuine effects or masquerade as legitimate neurogenic effects across the scalp in frequencies at least as low as the alpha band (8-13Hz). Although several techniques for correcting myogenic activity have been described, most are subjected to only limited validation attempts. Attempts to gauge the impact of EMG correction on intracerebral source models (source "localization" analyses) are rarer still. Accordingly, we assessed the sensitivity and specificity of one prominent correction tool, independent component analysis (ICA), on the scalp and in the source-space using high-density EEG. Data were collected from 17 participants while neurogenic and myogenic activity was independently varied. Several protocols for classifying and discarding components classified as myogenic and non-myogenic artifact (e.g., ocular) were systematically assessed, leading to the exclusion of one-third to as much as three-quarters of the variance in the EEG. Some, but not all, of these protocols showed adequate performance on the scalp. Indeed, performance was superior to previously validated regression-based techniques. Nevertheless, ICA-based EMG correction exhibited low validity in the intracerebral source-space, likely owing to incomplete separation of neurogenic from myogenic sources. Taken with prior work, this indicates that EMG artifact can substantially distort estimates of intracerebral spectral activity. Neither regression-nor ICA-based EMG correction techniques provide complete safeguards against such distortions. In light of these results, several practical suggestions and recommendations are made for intelligently using ICA to minimize EMG and other common artifacts.
The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

A mutant promoter's partner in crime Telomerase is an enzyme that maintains the ends of chromosomes. TERT, the gene coding for the enzyme's catalytic subunit, is not expressed in healthy somatic cells, but its expression is reactivated in the majority of human cancers. The resultant high levels of telomerase help cancer cells survive and multiply. Recurrent mutations in the promoter region of TERT are associated with high telomerase levels in multiple cancer types. Bell et al. show that a specific transcription factor called GABP is selectively recruited to the mutant form of the TERT promoter, which activates TERT gene expression Science, this issue p. 1036 Cancer-associated mutations in the promoter of the telomerase gene allow increased activation by transcription factor binding. Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, which are fundamental steps in the initiation of human cancer. Multiple cancer types, including up to 83% of glioblastomas (GBMs), harbor highly recurrent TERT promoter mutations of unknown function but specific to two nucleotide positions. We identified the functional consequence of these mutations in GBMs to be recruitment of the multimeric GA-binding protein (GABP) transcription factor specifically to the mutant promoter. Allelic recruitment of GABP is consistently observed across four cancer types, highlighting a shared mechanism underlying TERT reactivation. Tandem flanking native E26 transformation-specific motifs critically cooperate with these mutations to activate TERT, probably by facilitating GABP heterotetramer binding. GABP thus directly links TERT promoter mutations to aberrant expression in multiple cancers.
MUSCLE DAMAGE IN MDX (DYSTROPHIC) MICE: ROLE OF CALCIUM AND REACTIVE OXYGEN SPECIES

1 Duchenne muscular dystrophy (DMD) is a lethal, degenerative muscle disease caused by a genetic mutation that leads to the complete absence of the cytoskeletal protein dystrophin in muscle fibres. 2 The present review provides an overview of some of the physiological pathways that may contribute to muscle damage and degeneration in DMD, based primarily on experimental findings in the mdx mouse, an animal model of this disease. 3 A rise in intracellular calcium is widely thought to be an important initiating event in the dystrophic pathogenesis. The pathway(s) leading to increased intracellular calcium in dystrophin deficient muscle is uncertain, but recent work from our laboratory provides evidence that stretch‐activated channels are an important source of the calcium influx. Other possible routes of calcium entry are also discussed. 4 The consequences of elevated cytosolic calcium may include activation of proteases, such as calpain, and increased production of reactive oxygen species (ROS), which can cause protein and membrane damage. 5 Another possible cause of damage in dystrophic muscle involves inflammatory pathways, such as those mediated by neutrophils, macrophages and associated cytokines. There is recent evidence that increased ROS may be important in both the activation of and the damage caused by this inflammatory pathway in mdx muscle.
The Different Roles of Glucocorticoids in the Hippocampus and Hypothalamus in Chronic Stress-Induced HPA Axis Hyperactivity

Hypothalamus-pituitary-adrenal (HPA) hyperactivity is observed in many patients suffering from depression and the mechanism underling the dysfunction of HPA axis is not well understood. Chronic stress has a causal relationship with the hyperactivity of HPA axis. Stress induces the over-synthesis of glucocorticoids, which will arrive at all the body containing the brain. It is still complicated whether glucocorticoids account for chronic stress-induced HPA axis hyperactivity and in which part of the brain the glucocorticoids account for chronic stress-induced HPA axis hyperactivity. Here, we demonstrated that glucocorticoids were indispensable and sufficient for chronic stress-induced hyperactivity of HPA axis. Although acute glucocorticoids elevation in the hippocampus and hypothalamus exerted a negative regulation of HPA axis, we found that chronic glucocorticoids elevation in the hippocampus but not in the hypothalamus accounted for chronic stress-induced hyperactivity of HPA axis. Chronic glucocorticoids exposure in the hypothalamus still exerted a negative regulation of HPA axis activity. More importantly, we found mineralocorticoid receptor (MR) - neuronal nitric oxide synthesis enzyme (nNOS) - nitric oxide (NO) pathway mediated the different roles of glucocorticoids in the hippocampus and hypothalamus in regulating HPA axis activity. This study suggests that the glucocorticoids in the hippocampus play an important role in the development of HPA axis hyperactivity and the glucocorticoids in the hypothalamus can't induce hyperactivity of HPA axis, revealing new insights into understanding the mechanism of depression.
THE PERCEPTION OF SMS ADVERTISING INTRUSIVENESS DIFFERS BETWEEN AGE GROUP

Short messaging system (SMS) has overtaken the means of communicating and interacting between individuals today, regardless of age, gender, social class and boundaries. Organizations around the world today have incorporated SMS into their strategic marketing communication plans as one vital tool to reach out to their target customers. It rapidly becomes a vital media vehicle since it has precision targeting, personalization, customization and measurability, impact, persuasiveness and interactivity. Age is a widely used demographic variable to characterize the adoption of technologies between two or more consumer groups (Morris and Venkatesh, 2000). There are certain differences exist in their behavior because of their inherent motivational needs. This paper is looking at the perceptions of different age group towards the intrusiveness of SMS advertising and how their perception could affect their brand loyalty and purchase intention. 550 questionnaires were distributed to mobile phone users using systematic stratified random sampling method.
The use of video-based feedback in elite sport: an ethnography of practice

The use of video-based performance analysis has increased within multidisciplinary sports science support teams, but there remains a lack of research to underpin pedagogical practices. This thesis adopted an 18-month interpretive ethnographic approach, as part of a longitudinal case study with an elite Paralympic team, to better understand how video-based feedback sessions are delivered by coaches and interpreted by athletes. Data for this study was collected by using participant observations to explore the behaviours and interactions that occurred before, during and after video-based feedback sessions. Following an initial period of participant observation, interviews were conducted with the Head Coach (Greg) and Assistant Coach (Barry) to understand the aim of the video-based feedback work with the team (2.5 hours). Additionally, multiple video-based feedback sessions were audio recorded (20 hours) from training sessions and competitions prior to the Rio Paralympics. During the Games, pre- and post-match team briefings were audio recorded (6.5 hours), and afterwards, debriefing sessions and preparation for future competitions (6.5 hours) were also audio recorded. Following the Paralympics, Greg and Barry, five athletes and the Sports Psychologist (Sam) shared their thoughts and feelings within in-depth, one-to-one interviews regarding the use of video-based feedback (12 hours). This data, along with detailed field notes, were then subjected to a narrative analysis to identify key patterns and characteristics. The narratives were analysed drawing upon concepts from Goffman’s (1959) interactionist understanding of the presentation of self in everyday life, as a novel theoretical lens to understand the preparation undertaken for video-based feedback sessions. Findings revealed that the coaching team prepare for their ‘frontstage’ performances in a ‘backstage’ environment and they work together in a ‘performance team’ which keep ‘secrets’ from others. However, the ‘frontstage’ performance does not always go according to plan because individuals can adopt ‘discrepant roles’ that are not compatible with the ‘image’ they are trying to portray. Consequently, this thesis has contributed to the understanding of video-based feedback sessions by adopting novel methodological and theoretical approaches and further develops the existing performance analysis and sports coaching literature.
Author ' s personal copy Memory strength and speci fi city revealed by pupillometry

In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: a b s t r a c t a r t i c l e i n f o Voice-specificity effects in recognition memory were investigated using both behavioral data and pupillometry. Volunteers initially heard spoken words and nonwords in two voices; they later provided confidence-based old/ new classifications to items presented in their original voices, changed (but familiar) voices, or entirely new voices. Recognition was more accurate for old-voice items, replicating prior research. Pupillometry was used to gauge cognitive demand during both encoding and testing: enlarged pupils revealed that participants devoted greater effort to encoding items that were subsequently recognized. Further, pupil responses were sensitive to the cue match between encoding and retrieval voices, as well as memory strength. Strong memories, and those with the closest encoding-retrieval voice matches, resulted in the highest peak pupil diameters. The results are discussed with respect to episodic memory models and Whittlesea's (1997) SCAPE framework for recognition memory. In the present study, we examined the extent to which memory strength and specificity for spoken items are revealed by pupillome-try across learning and recognition. Although the speech signal is characterized by idiosyncratic variations that listeners must fluently overcome, debate surrounds the necessity of encoding this information into memory during on-line perception. For example, people encounter little perceptual resistance when processing the same words spoken by different speakers, each of whom has a unique vocal structure , pattern of intonation, and speaking rate. Changes in context and other non-linguistic variables similarly pose little challenge to the perceptual system. Speech perception is clearly robust to idiosyncratic variations in the input signal, but do these variations get " filtered out " during perception, or are they somehow stored in a detailed memory trace, capable of affecting subsequent perception or retrieval? Two general, and opposing, approaches to this problem have dominated the literature. According to the first, the speech signal is stripped of idiosyncratic information upon encoding, allowing the perceiver to activate abstract representations in memory (Joos, 1948). Such theories generally treat idiosyncratic variations as undesirable noise in the speech signal, a problem for the perceptual system to overcome (Pisoni, 1993). According to the second approach, surface properties …
Penerapan Model UTAUT Untuk Memahami Perilaku Pengguna Sistem Informasi Akademik

Use of information technology is important to the organization, because it can increase the effectiveness and efficiency of organizational performance. However, the implementation of information technology is not always successful. One of the critical success factors is the attitude of users who utilize it. UTAUT is a combination of eight models of user acceptance of technology that has been developed previously . Empirical studies that adopted the UTAUT model has been widely applied. UTAUT is also used by some researchers to look at the intentions and behavior of users of information technology in education. Therefore, this study was also developed by adopting the UTAUT model to see the user's intention of SIAK in STT Musidan STIE Musi. Four constructs of UTAUT used as a determinant of behavioral intention, namely: performance expectancy, effort expectancy, social influence and facilitating conditions. Data obtained through 300 questionnaires were distributed randomly to students of STT Musi and STIE Musi. The analysis showed that behavioral intention is significantly influenced by the performance expectancy, effort expectancy and facilitating conditions,social factors influence while no significant effect was found.
Hovering Information : Infrastructure-Free Self-Organising Location-Aware Information Dissemination Service

This paper proposes a location-based service for disseminating geo-localised information generated by and aimed at mobile users. The service itself works in a self-organising manner. A piece of hovering information is attached to a geographical point, called the anchor location, and to its vicinity area, called the anchor area. It is responsible for keeping itself alive, available and accessible to other devices within its anchor area. Hovering information uses mechanisms such as active hopping, replication and dissemination among mobile nodes to satisfy the above requirements. It does not rely on any central server. Previous results involving a single piece of hovering information have shown the interest of the concept. This paper reports on a series of simulations involving multiple pieces of hovering information. Our goal is to investigate the scalability of the technique up to 200 pieces in a small geographic area. Two main replication algorithms for pieces of hovering information are compared, an Attraction Point algorithm and a Broadcast-based one. These replication algorithms are combined with two different caching policies, Location-based and Generation-based, for discarding hovering information pieces from mobile nodes buffer when memory is not enough.
Pengaruh Kepuasan Kerja, Beban Kerja Dan Komitmen Organisasi Terhadap Turnover Intention Perawat RS. Bhayangkara TK. III Manado

Higher nurse turnover rates will have a serious impact on hospitals in the future. The results of this study are job satisfaction, workload and organizational commitment have a significant effect on simultaneous turnover intention. Job satisfaction has no significant effect on partial turnover intention. Workload has a positive and significant impact on partial turnover intention. Work commitment has a negative and significant effect on partial turnover intention Keywords: Job Satisfaction, Workload, Organizational commitment, Turnover Intention
Age-related sensitive periods influence visual language discrimination in adults

Adults as well as infants have the capacity to discriminate languages based on visual speech alone. Here, we investigated whether adults' ability to discriminate languages based on visual speech cues is influenced by the age of language acquisition. Adult participants who had all learned English (as a first or second language) but did not speak French were shown faces of bilingual (French/English) speakers silently reciting sentences in either language. Using only visual speech information, adults who had learned English from birth or as a second language before the age of 6 could discriminate between French and English significantly better than chance. However, adults who had learned English as a second language after age 6 failed to discriminate these two languages, suggesting that early childhood exposure is crucial for using relevant visual speech information to separate languages visually. These findings raise the possibility that lowered sensitivity to non-native visual speech cues may contribute to the difficulties encountered when learning a new language in adulthood.
Microbial Electrodialysis Cell for Simultaneous Water Desalination and Hydrogen Gas Production

A new approach to water desalination is to use exoelectrogenic bacteria to generate electrical power from the biodegradation of organic matter, moving charged ions from a middle chamber between two membranes in a type of microbial fuel cell called a microbial desalination cell. Desalination efficiency using this approach is limited by the voltage produced by the bacteria. Here we examine an alternative strategy based on boosting the voltage produced by the bacteria to achieve hydrogengasevolutionfromthecathodeusingathree-chambered system we refer to as a microbial electrodialysis cell (MEDC). We examined the use of the MEDC process using two different initial NaCl concentrations of 5 g/L and 20 g/L. Conductivity in the desalination chamber was reduced by up to 68 ( 3% in a single fed-batch cycle, with electrical energy efficiencies reaching 231 ( 59%, and maximum hydrogen production rates of 0.16 ( 0.05 m3 H2/m d obtained at an applied voltage of 0.55 V. The advantage of this system compared to a microbial fuel cell approach is that the potentials between the electrodes can be better controlled, and the hydrogen gas that is produced can be used to recover energy to make the desalination process self-sustaining with respect to electrical power requirements.
The Impact of Trust on School Principals' Leadership.

The impact of trust on working relationships has become a focus of discussion by educational researchers. However, the role trust plays in the relationship between principal and teacher has seen few studies undertaken and thus forms the basis for this study’s investigation. The primary aim of this study in contributing to educational research focuses on developing an understanding of the conditions that allow trust to develop and those that damage trust from being established or maintained between principal and staff member. This study is informed by a synthesis of theoretical and educational research of the dimensions of trust, and through a field-study, examination of the impact staff actions have on the maintenance and repair of trust and the impact these actions have on the principal. The main question of the study is: “What is the impact of trust on school principals’ leadership? ” The first phase of the research design incorporates a literature review to distil the current knowledge of trust, so as to establish a theoretical context for the study. The second phase of the study employs a qualitative research methodology engaging 20 Western Australian school principals in the process of recounting their observations of trust relationships in their schools. The links between phases of the study identify common themes. The study found that trust plays an important role in the establishment and maintenance of working relationships between school principals and their staff. The findings identify the importance of trust to principals; the conditions that promote and diminish trust in relationships, the outcomes of breaches of trust, and the conditions that allow for trust repair. The findings are discussed in the light of contemporary research of trust in related fields and recommendations are made for further research.
Impoliteness Strategies Used In Dailymail’s Comments

This research investigated impoliteness strategies used in Dailymail’s comments. It is qualitative research. The objectives of this research are describing the types of impoliteness strategies found dominantly and the conventional form of impoliteness in Dailymail’s comments. The data are the comments of Dailymail site. The researcher uses documentation method to collect the data, by doing some steps: reading and understanding the comments below the article, writing the data of impoliteness strategies found in the comments, and coding. The data were analyzed by the theory of impoliteness by Culpeper (2005) and conventional form of Culpeper’s theory (2010). There are 3 steps in analyzing the data, as follow: analyzing the impoliteness strategies in Dailymail’s comments, analyzing the conventional form of impoliteness, and drawing conclusion. The finding of this research shows that not all the impoliteness strategies found in this research. There are bald on record impoliteness, positive impoliteness, negative impoliteness, and offrecord impoliteness or sarcasm/mock impoliteness and pragmalinguistic of impoliteness strategies can be expressed with some form, such assessing, figurative language, rhetorical question, telling the truth, giving advice, etc.
Analysis on Factors Impacting to Information System Development

This study examines three project diversity, including project size, project member diversity, technical complexity; five critical success factors, including project objective and bound, top management support, project plan and monitoring, project user involvement, project communications; and six success criteria, including time, cost, quality, information quality, information use, user satisfaction. Through literature review, hypotheses, data collection, data analysis, validation, we get conclusions and recommendations. In this paper, we have found that five critical success factors including project objective and bound, top management support, project plan and monitoring, project user involvement, project communications would have significant impacts on the performance of the information system development projects. On the other words, that means we could gain success by controlling theses critical success factors. Furthermore, we also found that the factors have significant differences between the different projects.