Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationship between suicidal ideation and symptoms of depression in Japanese workers: a cross-sectional study

Objectives The prevalence of suicidal ideation and predictors for suicidal ideation among Japanese workers is unknown, although a previous study reported a 30% prevalence rate of suicidal ideation in a psychosomatic clinical setting. Hence, we evaluated the prevalence of suicidal ideation and its relationship with depressive symptoms among Japanese workers. Methods For this purpose, a cross-sectional design was used. Major depressive disorder (MDD) and suicidal ideation in 1266 workers (1100 men and 166 women, aged 20–69 years) were assessed through clinical interviews conducted in accordance with the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders. Results A total of 34 and 70 participants were diagnosed with suicidal ideation and MDD, respectively. Suicidal ideation was especially prevalent in 40-year-olds to 49-year-olds. Six of the eight symptoms of MDD (depressive mood, loss of interest, weight loss, psychomotor agitation, worthlessness and concentration loss) were related to suicidal ideation. Depressive mood had the strongest relationship with suicidal ideation, followed by worthlessness and concentration loss. Worthlessness had the highest area under the curve in predicting suicidal ideation, followed by concentration loss and depressive mood. Conclusions We conclude that MDD symptoms—particularly depressive mood, worthlessness and concentration loss—are potential predictors of suicidal ideation in Japanese workers.
Postnatal development of right atrial injection of capsaicin-induced apneic response in rats.

Apnea and respiratory failure often occur in infants with pulmonary disease. Bronchopulmonary C-fiber (PCF)-mediated apnea is an important component of respiratory dysfunction. This study was undertaken to define the postnatal development of PCF-mediated apnea. The experiments were conducted in five groups of anesthetized, tracheotomized, and spontaneously breathing rats with ages at postnatal days P1-3, P7-9, P14-16, P21-23, and P56-58. Right atrial bolus injection of three doses of capsaicin (Cap), equivalent to 2, 4, and 8 microg/kg used previously in 450-g rats, was applied to stimulate PCFs. We found that 1) Cap-induced apneic response [percent change from the baseline expiratory duration (Te) values (deltaTe%)] and the sensitivity of this response (deltaTe%.microg(-1)) were significantly greater in the rats P10; 2) the Cap-induced apneas were vagally dependent in all rats tested; and 3) bivagotomy-induced prolongation of Te was much greater in the rats P10. From these findings we concluded that, compared with the older rats (>P10), the newborn rats have a stronger PCF-mediated respiratory inhibition that may contribute to infants' vulnerability to respiratory failure.
An economic comparison of a laparoscopic electrocautery strategy and ovulation induction with recombinant FSH in women with clomiphene citrate-resistant polycystic ovary syndrome.

BACKGROUND Recombinant FSH (rFSH) is the current standard treatment for ovulation induction in women with polycystic ovary syndrome (PCOS) that do not respond to clomiphene citrate. Ovulation induction with rFSH is known to be costly due to the necessity of daily injections and intensive monitoring. An alternative strategy, starting with electrocautery of the ovaries, may be a less costly option. METHODS An economic evaluation was set up alongside a multicentre randomized clinical trial comparing laparoscopic electrocautery of the ovaries, followed by clomiphene citrate and rFSH when anovulation persisted, and treatment with rFSH in 168 women with clomiphene citrate-resistant PCOS. Data on resources used for treatment and productivity loss were collected prospectively up to an eventual ongoing pregnancy with a time horizon of 12 months. RESULTS At 12 months the ongoing pregnancy rates were 67% for both the electrocautery strategy and rFSH treatment. Mean total costs per woman were 5308 euros for the electrocautery strategy and 5925 euros for treatment with rFSH, resulting in a mean difference of 617 (95% CI: -382 euros to 1614 euros). CONCLUSIONS The total treatment costs up to an ongoing pregnancy are comparable for rFSH treatment and an alternative strategy starting with electrocautery. Due to a lower number of multiple pregnancies, the electrocautery strategy can be expected to result in lower total costs when costs of the delivery are included.
An Iterative Hungarian Algorithm Based Coordinated Spectrum Sensing Strategy

Coordinated spectrum sensing ensures Cognitive Radio systems to get the usability of every channel within the entire spectrum of interest by assigning terminals to detect different channels simultaneously. This letter proposes an optimized channel-assignment strategy for coordinated spectrum sensing based on an Iterative Hungarian Algorithm. Simulation results show that the proposed strategy performs excellently in improving the overall sensing performance of the system.
Replicated divergence in cichlid radiations mirrors a major vertebrate innovation

Decoupling of the upper jaw bones—jaw kinesis—is a distinctive feature of the ray-finned fishes, but it is not clear how the innovation is related to the extraordinary diversity of feeding behaviours and feeding ecology in this group. We address this issue in a lineage of ray-finned fishes that is well known for its ecological and functional diversity—African rift lake cichlids. We sequenced ultraconserved elements to generate a phylogenomic tree of the Lake Tanganyika and Lake Malawi cichlid radiations. We filmed a diverse array of over 50 cichlid species capturing live prey and quantified the extent of jaw kinesis in the premaxillary and maxillary bones. Our combination of phylogenomic and kinematic data reveals a strong association between biting modes of feeding and reduced jaw kinesis, suggesting that the contrasting demands of biting and suction feeding have strongly influenced cranial evolution in both cichlid radiations.
Quality of life among younger women with breast cancer.

PURPOSE To describe quality of life (QOL) of younger women 4 to 42 months after breast cancer diagnosis and to identify factors associated with impaired QOL. METHODS A total of 202 women diagnosed with stage I to III breast cancer at age 50 or younger from 4 to 42 months after breast cancer diagnosis previously completed a mailed survey. Global QOL; health-related QOL as measured by the Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B); medical history; symptoms; days of work/activity missed after diagnosis; relationship, sexual, and body image problems; coping strategies; and feelings of preparedness were measured. RESULTS General aches and pains and unhappiness with appearance were reported by more than 70% of women. Hot flashes (P = .0007), pain with sexual intercourse (P = .02), and difficulty with bladder control (P = .002) all significantly increased with age. Global QOL was significantly lower than for a nonpatient sample of younger women (P < .0001). In general, few sociodemographic and medical factors were related to QOL. In multivariate analyses, days of work/usual activity missed immediately after diagnosis; relationship, sexual, or body image problems after diagnosis; and coping strategies were related to almost all QOL domains. Ongoing treatment, vaginal dryness, and feeling unprepared for the impact of breast cancer were related to some domains. CONCLUSION Younger breast cancer survivors are at risk for impaired QOL up to several years after diagnosis. Younger women, especially those at high risk for lower QOL, may need interventions that specifically target their needs related to menopausal symptoms and problems with relationships, sexual functioning, and body image. Preparing younger woman for the impact of breast cancer may also prove beneficial.
H I Narrow Self-Absorption in Dark Clouds: Correlations with Molecular Gas and Implications for Cloud Evolution and Star Formation

We present the results of a comparative study of H I narrow self-absorption (HINSA), OH, 13CO, and C18O in five dark clouds. We find that the HINSA generally follows the distribution of the emission of the carbon monoxide isotopologs and has a characteristic size close to that of 13CO. This confirms earlier work that determined that the HINSA is produced by cold H I that is well mixed with molecular gas in well-shielded regions. The OH and 13CO column densities are essentially uncorrelated for the sources other than L1544. Our observations indicate that the central number densities of H I are between 2 and 6 cm-3 and that the ratio of the hydrogen density to total proton density for these sources is (5-27) × 10-4. Using cloud temperatures and the density of atomic hydrogen, we set an upper limit to the cosmic-ray ionization rate of 10-16 s-1. We present a model for H I to H2 conversion in well-shielded regions that includes cosmic-ray destruction of H2 and formation of this species on grain surfaces. We include the effect of a distribution of grain sizes, and we find that for an MRN distribution, the rate of H2 formation is increased by a factor of 3.4 relative to that for a model with a single grain radius of 1700 Å. Comparison of observed and modeled fractional H I abundances indicates ages for these clouds, defined as the time since the initiation of H → H2 conversion, to be 106.5-107 yr. Several effects may make this time a lower limit, but the low values of n that we have determined make it certain that the timescale for evolution from a possibly less dense atomic phase to an almost entirely molecular phase must be a minimum of several million years. This clearly sets a lower limit to the overall timescale for the process of star formation and the lifetime of molecular clouds.
Arsenic removal from drinking water using wood charcoal

Arsenic contamination of drinking water is threatening the health of millions of people of Bangladesh. Lack of appropriate arsenic removal technology has complicated and inhibited the mitigation initiatives. The effectiveness of wood charcoal for removal of arsenic from tubewell water was evaluated in this study. Arsenic contaminated water sample was passed through a pitcher having a small hole at its bottom contained wood charcoal at a controlled flow rate of 30 mL min−1 with different thickness of wood charcoal (7.5, 10, 12.5, 15, 17.5, 20 and 22.5 cm) and at different flow rates (10, 30, 50, 70, 90, 110 and 130 mL min−1) with 20 cm fixed thickness of wood charcoal. Results revealed that with the increased of flow rate the removal of arsenic percentage decreased. Maximum arsenic removal efficiency (93.68%) was obtained at a flow rate of 10 mL min−1 with 20 cm of charcoal thickness. In addition, it was also observed that both flow rate and charcoal thickness are critically important in achieving higher arsenic removal efficiency. Therefore, water flow rate of 50 mL min−1 with charcoal thickness of 15 cm could be used to remove arsenic from contaminated tube well water (arsenic concentration after filtration was 30 μg L−1 which is below the allowable arsenic concentration standard i.e. 50 μg L−1).
Immunohistochemical detection of membrane-type-1-matrix metalloproteinase in colorectal carcinoma

We investigated whether the expression of membrane-type-1 matrix metalloproteinase (MT1-MMP), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) was consistent with the proposed roles of these proteins in promoting metastasis in colorectal cancer. The expression of MT1-MMP was significantly more frequent in deeply invasive carcinomas (P = 0.007) and in cases of vascular invasion (P = 0.02). The frequency of detection of MMP-2 in the stroma was much greater in vascular invasion-positive cases (42%) than in negative cases (20%; P = 0.02). The rate of detection of TIMP-2 in tumour cell cytoplasm increased with the depth of invasion (P = 0.03). TIMP-2 in the stroma was found more frequently in tumours with lymphatic invasion and lymph node metastasis (P < 0.05). Significant correlations were found between detection of MT1-MMP and MMP-2 in tumour cell cytoplasm (P < 0.05), of MT1-MMP and TIMP-2 in tumour cell cytoplasm (P < 0.01), and of MMP-2 and TIMP-2 in tumour cell cytoplasm (P < 0.01). Immunohistochemical detection of MT1-MMP and TIMP-2 might be useful for monitoring infiltration in colorectal carcinoma but is not correlated with distant metastases. © 2000 Cancer Research Campaign
Responses of rabbit retinal ganglion cells to subretinal electrical stimulation using a silicon-based microphotodiode array.

PURPOSE With subretinal prostheses, retinal ganglion cells (RGCs) are activated by electrical stimulation of the retinal neural network. The aim of this study was to evaluate the efficacy of silicon-based solar cells in evoking RGC responses by electrically stimulating the photoreceptor side of an isolated retina. METHODS A light-bleached retina of an adult New Zealand White rabbit was placed with its photoreceptor side down onto a silicon chip that consisted of a 4 × 4 microphotodiode array (MPDA). The stimulating current was elicited by activating the solar cell with a 532-nm laser light source. Responses of the ON and OFF alpha RGCs on electrical stimulation were recorded extracellularly. Recorded RGCs were then injected with 4% N-(2-aminoethyl)-biotinamide hydrochloride to allow cell type identification. RESULTS Using a design that includes a circumvented ground electrode, the authors successfully evoked spiking responses by the ON and OFF alpha RGCs in an isolated rabbit retina using low light power to activate the MPDA (equivalent to 39 μC/cm(2)). The charge density-dependent response and the frequency-dependent pair-pulse suppression were characterized. The spike latency of the RGC responses triggered by electrical stimulation was equivalent to the latency of its light response, which supports the hypothesis that the activation is mediated by the retinal neural network. CONCLUSIONS Reliable activation of RGCs by electrical stimulation in vitro using an MPDA demonstrates the feasibility of developing solar cell-based subretinal prostheses that potentially could be developed into a power-free device able to restore vision.
Prediction of PIN diode reverse recovery

Generally, the reverse recovery issue of diode is difficult to deal with, which causes large added loss and EMI. Different down slopes for diode reverse voltage mean different working conditions, and this paper shows you the general concept with different down slopes and how to predict the reverse recovery current to calculate the relative switching loss. The empirical equations are deduced based on physical concepts and verified by lab measurements.
Detecting Changes of Arterial and Venous Blood Flow in Flaps

Island skin flaps based on the latissimus dorsi muscle were raised in domestic pigs. Simultaneous recordings of laser Doppler flowmetric and laser photometric values were made on the skin in the middle of the flap. Occlusion of either the artery or the vein of the pedicle was accompanied by very low laser Doppler flow values. In laser photometry the total intensity of backscattered light remained unchanged or was sightly increased during arterial occlusion. In response to venous occlusion, however, it decreased markedly.As venous outflow pressure was increased step by step, both the laser Doppler flow value and the laser photometry value fell proportionally; thus, the greater the increase in pressure the lower were the steady state levels of both variables. Stepwise reductions of arterial inflow pressure were followed by proportional decreases in both mean blood volume flow, recorded using electromagnetic flowmetry, and in laser Doppler flowmetric values. However, laser photometric values varied only minimally.Laser Doppler flowmetry thus might be a useful clinical aid in detecting decreased blood flow in transferred flaps, and laser photometry may determine whether the decreased flow is due to arterial or venous causes.
Hebbian Learning of Bayes Optimal Decisions

Uncertainty is omnipresent when we perceive or interact with our environment, and the Bayesian framework provides computational methods for dealing with it. Mathematical models for Bayesian decision making typically require data-structures that are hard to implement in neural networks. This article shows that even the simplest and experimentally best supported type of synaptic plasticity, Hebbian learning, in combination with a sparse, redundant neural code, can in principle learn to infer optimal Bayesian decisions. We present a concrete Hebbian learning rule operating on log-probability ratios. Modulated by reward-signals, this Hebbian plasticity rule also provides a new perspective for understanding how Bayesian inference could support fast reinforcement learning in the brain. In particular we show that recent experimental results by Yang and Shadlen [1] on reinforcement learning of probabilistic inference in primates can be modeled in this way.
Improving Social Well-Being Through New Democratic Institutions

We evaluate the role of a new type of democratic institution, participatory budgeting (PB), for improving citizens’ well-being. Participatory institutions are said to enhance governance, citizens’ empowerment, and the quality of democracy, creating a virtuous cycle to improve the poor’s well-being. Drawing from an original database of Brazil’s largest cities over the last 20 years, we assess whether adopting PB programs influences several indicators of well-being inputs, processes, and outcomes. We find PB programs are strongly associated with increases in health care spending, increases in civil society organizations, and decreases in infant mortality rates. This connection strengthens dramatically as PB programs remain in place over longer time frames. Furthermore, PB’s connection to well-being strengthens in the hand of mayors from the nationally powerful, ideologically and electorally motivated Workers’ Party. Our argument directly addresses debates on democracy and well-being and has powerful implications for participation, governance, and economic development.
Dynamics of Dynamics within a Single Data Acquisition Session: Variation in Neocortical Alpha Oscillations in Human MEG

Background Behavioral paradigms applied during human recordings in electro- and magneto- encephalography (EEG and MEG) typically require 1–2 hours of data collection. Over this time scale, the natural fluctuations in brain state or rapid learning effects could impact measured signals, but are seldom analyzed. Methods and Findings We investigated within-session dynamics of neocortical alpha (7–14 Hz) rhythms and their allocation with cued-attention using MEG recorded from primary somatosensory neocortex (SI) in humans. We found that there were significant and systematic changes across a single ∼1 hour recording session in several dimensions, including increased alpha power, increased differentiation in attention-induced alpha allocation, increased distinction in immediate time-locked post-cue evoked responses in SI to different visual cues, and enhanced power in the immediate cue-locked alpha band frequency response. Further, comparison of two commonly used baseline methods showed that conclusions on the evolution of alpha dynamics across a session were dependent on the normalization method used. Conclusions These findings are important not only as they relate to studies of oscillations in SI, they also provide a robust example of the type of dynamic changes in brain measures within a single session that are overlooked in most human brain imaging/recording studies.
Novel lineages of Giardia intestinalis identified by genetic analysis of organisms isolated from dogs in Australia

Infection of suckling mice with Giardia trophozoites recovered from the intestines of 11 dogs autopsied in Central and Southern Australia in each case produced an established isolate. In contrast, only 1 isolate was obtained by inoculation of faecal cysts. The organisms grew poorly in comparison with isolates from humans or non-canine animal hosts. Light microscopy revealed that the trophozoites had median bodies with the ‘claw hammer’ appearance typical of G. intestinalis (syn. G. duodenalis, G. lamblia) but that they differed in shape and nuclear morphology from axenic isolates of human or canine origin. Allozymic analysis of electrophoretic data representing 26 loci and phylogenetic analysis of nucleotide sequences obtained from DNA amplified from the glutamate dehydrogenase locus showed that the 11 isolates examined from Australian dogs were genetically distinct from all isolates of G. intestinalis that have been established previously from humans and animals, and also from G. muris. Both analytical methods placed 10 of the Australian canine isolates into a unique genetic lineage (designated Assemblage C) and the eleventh into a deep-rooted second branch (designated Assemblage D), each well separated from the 2 lineages (Assemblages A and B) of G. intestinalis that encompass all the genotypes known to infect humans. In contrast, 4 axenic isolates derived from dogs in Canada and Europe (the only other isolates to have been established from dogs) have genotypes characteristic of genetic Assemblages A or B. The findings indicate that the novel Giardia identified in these rural Australian dogs have a restricted host range, possibly confined to canine species. The poor success rate in establishing Giardia from dogs in vitro suggests, further, that similar genotypes may predominate as canine parasites world-wide. The absence of such organisms among isolates of Giardia that have been established from humans by propagation in suckling mice indicates that they are unlikely to infect humans. However, infection of humans by those dog-derived genotypes that grow in vitro cannot be excluded.
Performance Evaluation and ParameterOptimization of MC-CDMA

The performance of multicarrier systems depends on the propagation channel behavior. The latter is subject to time and/or frequency selectivity. The designer has to select properly the guard interval and the number of carriers for a given system bandwidth to combat the channel dispersiveness. In this paper, we investigate the sensitivity of downlink multicarrier code-division multiple-access (MC-CDMA) performance to these parameters in different environments. We derive closed-form expressions of the useful and the different interference powers after maximum ratio combining and despreading. The optimum parameters correspond to the minimum of the signal-to-noise-ratio degradation. It turns out that the derivations in the paper of Steendam and Moeneclaey ( IEEE Trans. Commun., 1999) that are restricted to the orthogonal frequency-division multiplexing (OFDM) system are a particular case of our results. Numerical evaluation of the analytical expressions reveals that the optimum parameters of the MC-CDMA and its corresponding OFDM system are similar and depend in the same way on the channel characteristics. We show in this paper that the load of the MC-CDMA system only has small influence on the optimization of the parameters. Therefore, from the point of view of parameter optimization, single-user transmission is sufficient to find the optimum parameters. Furthermore, as the optimum parameters mainly depend on the channel characteristics, similar conclusions can be drawn for the uplink transmission