Miracle-dz/UniFAR-FTUs huggingface dataset:
Fracture toughness assessment of ACF flip-chip packages under high moisture condition with moire interferometry

A primary factor of ACF package failure is delamination between the chip and the adhesive at the edge of the chip. This delamination is mainly affected by the normal strain at the edge of the chip. This normal strain was measured on various electronic ACF package specimens by micro Moiré interferometry with a phase shifting method. In order to find the effect of moisture, the reliability performance of an adhesive flip chip in the moisture environment was investigated. The failure modes were found to be interfacial delamination and bump/pad opening which may eventually lead to total loss of electrical contact. Different geometric size specimens in terms of interconnections were discussed in the context of the significance of mismatch in CME between the adhesive and other components in the package, which induces hygroscopic swelling stress. Interfacial fracture toughness between ACF and die chip were evaluated by peel test. The effect of moisture diffusion in the package and the CME mismatch were also evaluated by using the Moiré interferometry. From Moiré measurement results, we could also obtain the stress intensity factor K. Through an analysis of deformations induced by thermal and moisture environments, a damage model for an adhesive flip chip package is proposed.
Tooling Design and Compaction Analysis on P/M Copper Bushes

The successful production of P/M (powder metallurgy) components depends to a large extent on the tooling used for powder compaction. While designing the tool, the complexities arise from the interaction of the parameters such as powder characteristics, expected green density, the size and geometry of the product, and to whom the properties of the tool materials during compaction should be addressed. Floating type of compaction tooling set (die, punches, and core rod) was designed and fabricated. Pure electrolytic copper powder was compacted in the above-mentioned tool to obtain P/M copper bushes. Compaction pressure–density relationship and their influence on green strength are analyzed.
The Prevalence of Peripheral Arterial Disease in Korean Patients with Type 2 Diabetes Mellitus Attending a University Hospital

Background Peripheral arterial disease (PAD) is a common manifestation of systemic atherosclerosis and is associated with significant morbidity and mortality. Diabetes is known to increase the risk of PAD two- to four-fold. The prevalence of PAD in Korean diabetic patients has not been established. In this study, we investigated the prevalence of PAD in Korean patients with type 2 diabetes attending a large university hospital and analyzed the factors associated with PAD. Methods A total of 2,002 patients with type 2 diabetes who underwent ankle-brachial index (ABI) measurement in an outpatient clinic were enrolled. PAD was defined as an ABI ≤0.9. Clinical characteristics of 64 patients with PAD were compared with those of 192 age- and sex-matched control patients without PAD. Results Of the 2,002 type 2 diabetic patients, 64 (3.2%) were diagnosed as having PAD. PAD was associated with higher prevalences of retinopathy, nephropathy, neuropathy, cerebrovascular and coronary artery disease. Patients with PAD had higher systolic blood pressure and serum triglyceride level and reported higher pack-years of smoking. Multivariate analysis showed that the presence of micro- and macrovascular complications and high systolic blood pressure are factors independently associated with PAD. Conclusion The prevalence of PAD in diabetic patients was 3.2%, suggesting that the prevalence in Korean diabetic patients is lower than that of patients in Western countries.
Chronic Effects of Polychlorinated Dibenzofurans on Mink in Laboratory and Field Environments

Abstract Mink are often used as a sentinel species in ecological risk assessments of chemicals such as polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) that cause toxicity mediated through the aromatic hydrocarbon receptor. Considerable toxicological information is available on the effects of PCBs and PCDDs on mink, but limited toxicological information is available for PCDFs. Thus, exposure concentrations at which adverse effects occur could not be determined reliably for complex mixtures in which PCDFs dominate the total calculated concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent (TEQ). Two studies were conducted to evaluate the potential toxicity of PCDFs to mink. The first was a chronic exposure, conducted under controlled laboratory conditions, in which mink were exposed to 2,3,7,8-tetrachlorodibenzofuran (2,3,7,8-TCDF) concentrations as great as 2.4 × 103 ng 2,3,7,8-TCDF/kg wet-weight (ww) diet or 2.4 × 102 ng TEQ2006-WHO-mammal/kg ww diet. In that study, transient decreases in body masses of kits relative to the controls was the only statistically significant effect observed. The second study was a 3-y field study during which indicators of individual health, including hematological and morphological parameters, were determined for mink exposed chronically to a mixture of PCDDs and PCDFs under field conditions. In the field study, there were no statistically significant differences in any of the measured parameters between mink exposed to a median estimated dietary dose of 31 ng TEQ2006-WHO-mammal/kg ww and mink from an upstream reference area where they had a median dietary exposure of 0.68 ng TEQ2006-WHO-mammal/kg ww. In both studies, concentrations of TEQ2006-WHO-mammal to which the mink were exposed exceeded those at which adverse effects, based on studies with PCDD and PCB congeners, would have been expected. Yet in both instances where PCDF congeners were the sole or predominant source of the TEQ2006-WHO-mammal, predicted adverse effects were not observed. Taken together, the results of these studies suggest that the values of the mammalian-specific toxicity equivalency factors suggested by the World Health Organization overestimate the toxic potency of PCDFs to mink. Therefore, hazard cannot be accurately predicted by making comparisons to toxicity reference values derived from exposure studies conducted with PCBs or PCDDs in situations where mink are exposed to TEQ mixtures dominated by PCDFs.
Infective Endocarditis in the Transcatheter Aortic Valve Replacement Era: Comprehensive Review of a Rare Complication

In recent years, transcatheter aortic valve replacement (TAVR) has emerged as a revolutionary alternative for surgical aortic valve replacement (SAVR) for the treatment of severe symptomatic aortic stenosis in patients at high risk for surgery. Prosthetic aortic valve endocarditis is a serious complication after SAVR with high morbidity and mortality. Although numerous TAVR procedures have been performed worldwide, infective endocarditis (IE) after TAVR was reported in the literature in few cases only and in 0% to 2.3% of patients enrolled in large TAVR cohorts. Our aim was to review the literature for IE following TAVR and to discuss the diagnostic and management strategies of this rare complication. Ten case reports of IE after TAVR were identified, 8 of which were published as case reports and 2 of which were presented in congresses. Infective endocarditis occurred in a mean time period of 186 days (median, 90 days) after TAVR. Most cases were characterized by fever and elevated inflammatory markers. Infective endocarditis after TAVR shared some common characteristics with IE after SAVR, yet it has some unique features. Echocardiographic findings included leaflet vegetations, severe mitral regurgitation with rupture of the anterior leaflet, and left ventricle outflow tract to left atrium fistula. Bacteriologic findings included several atypical bacteria or fungi. Cases of IE were managed either conservatively by antibiotics and/or using surgery, and the overall prognosis was poor. Infective endocarditis after TAVR deserves prompt diagnosis and treatment. Until further evidence is present, IE after TAVR should be managed according to SAVR guidelines with modifications as needed on a case‐by‐case basis.
Challenges of Ground Truth Evaluation of Multi-target Tracking

Evaluating multi-target tracking based on ground truth data is a surprisingly challenging task. Erroneous or ambiguous ground truth annotations, numerous evaluation protocols, and the lack of standardized benchmarks make a direct quantitative comparison of different tracking approaches rather difficult. The goal of this paper is to raise awareness of common pitfalls related to objective ground truth evaluation. We investigate the influence of different annotations, evaluation software, and training procedures using several publicly available resources, and point out the limitations of current definitions of evaluation metrics. Finally, we argue that the development an extensive standardized benchmark for multi-target tracking is an essential step toward more objective comparison of tracking approaches.
Is childhood immunisation associated with atopic disease from age 7 to 32 years?

Background: There is ongoing conjecture over whether childhood immunisation leads to an increased risk of developing atopic diseases. Objective: To examine associations between childhood immunisation and the risk of atopic disease. Method: Immunisation histories of 8443 Tasmanian children born in 1961 obtained from school medical records were linked to the Tasmanian Asthma Study. Associations between immunisation status and atopic diseases were examined while adjusting for possible confounders using multiple logistic regression. Results: Diphtheria immunisation was weakly associated with an increased risk of asthma by age 7 years (odds ratio (OR) 1.3, 95% confidence interval (CI) 1.1 to 1.7), but there was no evidence of any association for four other vaccinations studied. An increased risk of eczema by age 7 years was associated with immunisation against diphtheria (OR 1.5, 95% CI 1.1 to 2.1), tetanus (OR 1.5, 95% CI, 1.1 to 2.0), pertussis (OR 1.5, 95% CI 1.1 to 1.9) and polio (OR 1.4, 95% CI 1.0 to 1.9) but not small pox. Similar but slightly weaker patterns of association were observed between the risk of food allergies and immunisation against diphtheria (OR 1.5, 95% CI 1.0 to 2.1), pertussis (OR 1.4, 95% CI 1.1 to 1.9), polio (OR 1.4, 95% CI 1.00 to 2.1) and tetanus (OR 1.30 95% CI 0.99 to 1.70), but not with small pox. There was no evidence of associations between immunisation history and hay fever, or incidence of later-onset atopic outcomes. Conclusions: The few effects seen in this study are small and age-dependent, and nearly all our findings support numerous previous studies of no effect of vaccines on asthma. Based on these findings, the fear of their child developing atopic disease should not deter parents from immunising their children, especially when weighed against the benefits.
Experimental Investigation of Single-Event Transient Waveforms Depending on Transistor Spacing and Charge Sharing in 65-nm CMOS

Single-event cross sections of four inverter chains, with uniform inverter spacing ranging from 120 nm to $4~\mu \text{m}$ , were experimentally measured and compared. These inverter chains were irradiated using a focused ion beam. Full analog waveforms of responses were sensed using on-chip wide-bandwidth analog multiplexers. Cross sections are examined with respect to pulse heights and pulse widths, for direct-hit waveforms as well as for waveforms propagated through the chain. The influence of ion hit position and charge sharing effects on the initial shape and propagation of the single-event transients (SETs) was analyzed. We have observed a considerable reduction of cross section for tightly spaced inverters, for both direct hits and propagated SETs.
Radiation effects on optical fibers and amplifiers

The effects of gamma radiation on rare-earth doped optical fibers have been investigated over the range of 0.01 to 145 kilorads(Si) per hour to total doses exceeding 100 kilorads(Si). The effects of 3 to 4 MeV protons have also been investigated. The level of radiation induced damage has been found to be strongly dependent on radiation dose rate and fiber composition. The existence of dose rate dependence is explained by the process of simultaneous creation of color center defects and annihilation via thermal annealing. Through the use of a suitable kinetic analysis technique, we have determined appropriate rate constants for this process and have developed an empirical model based on our experimental results. In addition to these results, we present the effects of gamma radiation on the performance of operational high power erbium-ytterbium optical amplifiers.
Solving the MEG Inverse Problem: A Robust Two-Way Regularization Method

Magnetoencephalography (MEG) is a common noninvasive imaging modality for instantly measuring whole brain activities. One challenge in MEG data analysis is how to minimize the impact of the outliers that commonly exist in the images. In this article, we propose a robust two-way regularization approach to solve the important MEG inverse problem, that is, reconstructing neuronal activities using the measured MEG signals. The proposed method is based on the distributed source model and produces a spatio-temporal solution for all the dipoles simultaneously. Unlike the traditional methods that use the squared error loss function, our proposal uses a robust loss function, which improves the robustness of the results against outliers. To impose desirable spatial focality and temporal smoothness, we then penalize the robust loss through appropriate spatial–temporal two-way regularization. Furthermore, an alternating reweighted least-squares algorithm is developed to optimize the penalized model fitting criterion. Extensive simulation studies and a real-world MEG study clearly demonstrate the advantages of the proposed method over three nonrobust methods.
Tenure, Experience, Human Capital, and Wages: A Tractable Equilibrium Search Model of Wage Dynamics

We develop and estimate an equilibrium job search model of worker careers, allowing for human capital accumulation, employer heterogeneity and individual-level shocks. Career wage growth is decomposed into the contributions of human capital and job search, within and between jobs. Human capital accumulation is largest for highly educated workers, and both human capital accumulation and job search contribute to the observed concavity of wage-experience pro files. The contribution from job search to wage growth, both within- and between-job, declines over the fi rst ten years of a career- the `job-shopping' phase of a working life - after which workers settle into high-quality jobs and use outside off ers to generate gradual wage increases, thus reaping the benefi ts from competition between employers.
Application of a Socio-Ecological Model to Mother–Infant Bed-Sharing

Mother–infant bed-sharing has been associated with an increased risk of sleep-related infant deaths, and thus, health messaging has aimed to discourage this behavior. Despite this messaging, bed-sharing remains a common practice in the United States, especially among minority families. Moreover, rates of accidental suffocation and strangulation in bed (often related to bed-sharing) are on the rise, with Black infants at two to three times greater risk than Whites. Multiple studies have identified risk factors for bed-sharing, but a gap remains between findings and translation into interventions. The socio-ecological model (SEM) has been suggested as a way to study and design interventions addressing complex public health issues. This article reconceptualizes the literature on mother–infant bed-sharing using the SEM. PubMed, POPLINE, ERIC, and Psych Info were searched for articles that (a) included bed-sharing as the outcome variable, (b) were published between 2000 and 2013, (c) were conducted in the United States, and (d) included quantitative comparison of more than one factor. The following data were extracted: sample characteristics, bed-sharing definition, methods, factors examined, key findings, and conclusions. Data were summarized into five SEM levels—infant, maternal, family and household, and community and society, nested within the historical context of race. Sixteen studies met inclusion criteria. Significant factors associated with bed-sharing were present within each SEM level of influence. Educational interventions may increase efficacy by attending to multiple levels of the SEM, especially when implementing such interventions within minority subpopulations. Using a harm reduction approach to reducing the risk around bed-sharing may be one way to account for the multiple influences on bed-sharing. The science and practice of minimizing mother–infant bed-sharing may be advanced through use of the SEM.
Strategies and Methodologies for Developing Microbial Detoxification Systems to Mitigate Mycotoxins

Mycotoxins, the secondary metabolites of mycotoxigenic fungi, have been found in almost all agricultural commodities worldwide, causing enormous economic losses in livestock production and severe human health problems. Compared to traditional physical adsorption and chemical reactions, interest in biological detoxification methods that are environmentally sound, safe and highly efficient has seen a significant increase in recent years. However, researchers in this field have been facing tremendous unexpected challenges and are eager to find solutions. This review summarizes and assesses the research strategies and methodologies in each phase of the development of microbiological solutions for mycotoxin mitigation. These include screening of functional microbial consortia from natural samples, isolation and identification of single colonies with biotransformation activity, investigation of the physiological characteristics of isolated strains, identification and assessment of the toxicities of biotransformation products, purification of functional enzymes and the application of mycotoxin decontamination to feed/food production. A full understanding and appropriate application of this tool box should be helpful towards the development of novel microbiological solutions on mycotoxin detoxification.
The form and function of extra-sentential elements *

Astruc-Aguilera, Lluisa (2005). The form and function of extra-sentential elements. Cambridge Occa-sional Papers in Linguistics, 2 pp. 1–25.For guidance on citations see FAQs.c 2005 Llu¨isa Astruc-AguileraVersion: Accepted ManuscriptLink(s) to article on publisher’s website:http://www.ling. cam.ac. uk/COPIL/volumes.htmlCopyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copy-right owners. For more information on Open Research Online’s data policy on reuse of materials please consultthe policies page.
Verifying Sequential Consistency on Shared-Memory Multiprocessors by Model Checking

The memory model of a shared-memory multiprocessor is a contract between the designer and the programmer of the multiprocessor. A memory model is typically implemented by means of a cache-coherence protocol. The design of this protocol is one of the most complex aspects of multiprocessor design and is consequently quite error-prone. However, it is imperative to ensure that the cache-coherence protocol satisfies the shared-memory model. We present a novel technique based on model checking to tackle this difficult problem for the important and well-known shared-memory model of sequential consistency. Surprisingly, verifying sequential consistency is undecidable in general, even for finite-state cache-coherence protocols. In practice, cache-coherence protocols satisfy the properties of causality and data independence. Causality is the property that values of read events flow from values of write events. Data independence is the property that all traces can be generated by renaming data values from traces where the written values are pairwise distinct. We show that, if a causal and data independent system also has the property that the logical order of write events to each location is identical to their temporal order, then sequential consistency is decidable. We present a novel model checking algorithm to verify sequential consistency on such systems for a finite number of processors and memory locations and an arbitrary number of data values.
Generalized spatial dirichlet process models

Many models for the study of point-referenced data explicitly introduce spatial random effects to capture residual spatial association. These spatial effects are customarily modelled as a zero-mean stationary Gaussian process. The spatial Dirichlet process introduced by Gelfand et al. (2005) produces a random spatial process which is neither Gaussian nor stationary. Rather, it varies about a process that is assumed to be stationary and Gaussian. The spatial Dirichlet process arises as a probability-weighted collection of random surfaces. This can be limiting for modelling and inferential purposes since it insists that a process realization must be one of these surfaces. We introduce a random distribution for the spatial effects that allows different surface selection at different sites. Moreover, we can specify the model so that the marginal distribution of the effect at each site still comes from a Dirichlet process. The development is offered constructively, providing a multivariate extension of the stick-breaking representation of the weights. We then introduce mixing using this generalized spatial Dirichlet process. We illustrate with a simulated dataset of independent replications and note that we can embed the generalized process within a dynamic model specification to eliminate the independence assumption. Copyright 2007, Oxford University Press.
Optimal fidelity multi-level Monte Carlo for quantification of uncertainty in simulations of cloud cavitation collapse

We quantify uncertainties in the location and magnitude of extreme pressure spots revealed from large scale multi-phase flow simulations of cloud cavitation collapse. We examine clouds containing 500 cavities and quantify uncertainties related to their initial spatial arrangement. The resulting 2000-dimensional space is sampled using a non-intrusive and computationally efficient Multi-Level Monte Carlo (MLMC) methodology. We introduce novel optimal control variate coefficients to enhance the variance reduction in MLMC. The proposed optimal fidelity MLMC leads to more than two orders of magnitude speedup when compared to standard Monte Carlo methods. We identify large uncertainties in the location and magnitude of the peak pressure pulse and present its statistical correlations and joint probability density functions with the geometrical characteristics of the cloud. Characteristic properties of spatial cloud structure are identified as potential causes of significant uncertainties in exerted collapse pressures.
Tsga10 Encodes a 65-Kilodalton Protein That Is Processed to the 27-Kilodalton Fibrous Sheath Protein1

Abstract We had previously reported the isolation of the testis-specific human gene Tsga10, which is not expressed in testes from two infertile patients. To study its role and function, we cloned the mouse homologue Mtsga10. Mtsga10 localizes to mouse chromosome 1, band B. This region is syntenic with human chromosome 2q11.2, where Tsga10 is located. We demonstrate that Mtsga10 mRNA is expressed in testis, but not in other adult tissues, and in several human fetal tissues and primary tumors. We uncovered that different species use different first exons and, consequently, different promoters. Using several antibodies, we discovered that, in mouse testis, Mtsga10 encodes a 65-kDa spermatid protein that appears to be processed to a 27-kDa protein of the fibrous sheath, a major sperm tail structure, in mature spermatozoa. Mtsga10 protein contains a putative myosin/Ezrin/radixin/moesin (ERM) domain. Transfection of fibroblasts with GFP-Mtsga10 fusion protein results in formation of short, thick filaments and deletion of the myosin/ERM domain abolished filament formation. Our results suggest the possibility that Tsga10 plays a role in the sperm tail fibrous sheath.