Miracle-dz/UniFAR-FTUs huggingface dataset:
Abuse Reporting and the Fight Against Cybercrime

Cybercriminal activity has exploded in the past decade, with diverse threats ranging from phishing attacks to botnets and drive-by-downloads afflicting millions of computers worldwide. In response, a volunteer defense has emerged, led by security companies, infrastructure operators, and vigilantes. This reactionary force does not concern itself with making proactive upgrades to the cyber infrastructure. Instead, it operates on the front lines by remediating infections as they appear. We construct a model of the abuse reporting infrastructure in order to explain how voluntary action against cybercrime functions today, in hopes of improving our understanding of what works and how to make remediation more effective in the future. We examine the incentives to participate among data contributors, affected resource owners, and intermediaries. Finally, we present a series of key attributes that differ among voluntary actions to investigate further through experimentation, pointing toward a research agenda that could establish causality between interventions and outcomes.
Drug-Induced Trafficking of P-Glycoprotein in Human Brain Capillary Endothelial Cells as Demonstrated by Exposure to Mitomycin C

P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), restricting the penetration of various compounds. In other tissues, trafficking of Pgp from subcellular stores to the cell surface has been demonstrated and may constitute a rapid way of the cell to respond to toxic compounds by functional membrane insertion of the transporter. It is not known whether drug-induced Pgp trafficking also occurs in brain capillary endothelial cells that form the BBB. In this study, trafficking of Pgp was investigated in human brain capillary endothelial cells (hCMEC/D3) that were stably transfected with a doxycycline-inducible MDR1-EGFP fusion plasmid. In the presence of doxycycline, these cells exhibited a 15-fold increase in Pgp-EGFP fusion protein expression, which was associated with an increased efflux of the Pgp substrate rhodamine 123 (Rho123). The chemotherapeutic agent mitomycin C (MMC) was used to study drug-induced trafficking of Pgp. Confocal fluorescence microscopy of single hCMEC/D3-MDR1-EGFP cells revealed that Pgp redistribution from intracellular pools to the cell surface occurred within 2 h of MMC exposure. Pgp-EGFP exhibited a punctuate pattern at the cell surface compatible with concentrated regions of the fusion protein in membrane microdomains, i.e., lipid rafts, which was confirmed by Western blot analysis of biotinylated cell surface proteins in Lubrol-resistant membranes. MMC exposure also increased the functionality of Pgp as assessed in three functional assays with Pgp substrates (Rho123, eFluxx-ID Gold, calcein-AM). However, this increase occurred with some delay after the increased Pgp expression and coincided with the release of Pgp from the Lubrol-resistant membrane complexes. Disrupting rafts by depleting the membrane of cholesterol increased the functionality of Pgp. Our data present the first direct evidence of drug-induced Pgp trafficking at the human BBB and indicate that Pgp has to be released from lipid rafts to gain its full functionality.
A Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric Aggregates

The presence of oligomeric aggregates, which is often observed during the process of amyloid formation, has recently attracted much attention because it has been associated with a range of neurodegenerative conditions including Alzheimer's and Parkinson's diseases. We provide a description of a sequence-indepedent mechanism by which polypeptide chains aggregate by forming metastable oligomeric intermediate states prior to converting into fibrillar structures. Our results illustrate that the formation of ordered arrays of hydrogen bonds drives the formation of β-sheets within the disordered oligomeric aggregates that form early under the effect of hydrophobic forces. Individual β-sheets initially form with random orientations and subsequently tend to align into protofilaments as their lengths increase. Our results suggest that amyloid aggregation represents an example of the Ostwald step rule of first-order phase transitions by showing that ordered cross-β structures emerge preferentially from disordered compact dynamical intermediate assemblies.
In-vivo local determination of tissue optical properties

Local and superficial optical characterization of biological tissues can be achieved by measuring the spatially resolved diffuse reflectance at small source-detector separations. The sensitivity of the signal to the phase function, absorption and scattering coefficients were studied using Monte Carlo simulations. Measurements of spatially resolved reflectance were performed in vivo on human brain with source-detector separations from 0.3 to 1.5 mm. Distinct optical properties were found between normal cortex, astrocytoma of optic nerve and normal optic nerve.
ANTHROPIC ACTIVITY AND ITS INFLUENCE ON A NATURAL CAVITY: EFFECTS ON FUNGAL SPORE LEVELS IN THE AIR OF THE CAVE OF NERJA

The Cave of Nerja is one of the biggest and most visited caves in the world. It is situated near the village of the same name, southern Spain. This coastal town, (21 metres above sea level), is located 65 km east of the capital of the province, Malaga, on the border with the province of Granada (Figure 1). The cave was discovered in 1959, although there is much evidence of the presence of prehistoric cultures that dwelled in it from the Palaeolithic to the Bronze Age (Sanchidrian 1994). It was formed by the dissolution of the calciummagnesium carbonate of the dolomitic rocks that comprise the mountain range of Almijara and is divided into two zones: the low galleries, which can be visited by tourists and the general public (representing a third of the total), and the high galleries which cannot be visited. The genesis of the cave started in the Pliocene but the greatest lithogenic activity took place during the middle Pliocene (Carrasco 1993).
Optimizing Bulk Transfers with Software-Defined Optical WAN

Bulk transfer on the wide-area network (WAN) is a fundamental service to many globally-distributed applications. It is challenging to efficiently utilize expensive WAN bandwidth to achieve short transfer completion time and meet mission-critical deadlines. Advancements in software-defined networking (SDN) and optical hardware make it feasible and beneficial to quickly reconfigure optical devices in the optical layer, which brings a new opportunity for traffic management on the WAN. We present Owan, a novel traffic management system that optimizes wide-area bulk transfers with centralized joint control of the optical and network layers. \sysname can dynamically change the network-layer topology by reconfiguring the optical devices. We develop efficient algorithms to jointly optimize optical circuit setup, routing and rate allocation, and dynamically adapt them to traffic demand changes. We have built a prototype of Owan with commodity optical and electrical hardware. Testbed experiments and large-scale simulations on two ISP topologies and one inter-DC topology show that \sysname completes transfers up to 4.45x faster on average, and up to 1.36x more transfers meet their deadlines, as compared to prior methods that only control the network layer.
The Role of Internally Generated Neural Activity in Newborn and Infant Face Preferences

Infant face perception is controversial, but the current evidence suggests that (a) newborns orient to and follow face-like schematic patterns more than similar patterns, (b) infants can learn individual faces soon after birth, and (c) full face-processing abilities develop through months or years of experience with faces. Together, these capabilities have proved difficult to explain in terms of either environment-driven learning or genetically hardwired abilities. Accordingly, researchers have proposed that multiple visual processing areas may be involved, some hardwired and some plastic. New discoveries of widespread spontaneous neural activity during development suggest an alternative explanation: a single plastic visual processing system may learn from both spontaneous and visually evoked activity. In simulations with a biologically based computational model, we show that such internally generated patterns and a learning system can account for a wide range of these seemingly contradictory experimental results. The results suggest that learning of both internally generated and environmentally evoked activity may be a general feature of brain development.
Back‐Projection Imaging of Extended, Diffuse Sources of Volcano‐Tectonic Seismicity During June 2010 at Sierra Negra Volcano, Galápagos

Seismic signals generated by subsurface volcano‐tectonic processes commonly have low signal‐to‐noise ratios that make it difficult to resolve both 3‐D subsurface structures and seismic source locations using established seismic imaging methods (e.g., phase picking, template matching). High‐amplitude bursts within the noise (i.e., eruptions) are sometimes suitable for traditional seismic imaging but occur infrequently relative to the duration of a systems eruption cycle and offer minimal insight into mechanisms that occur during more common intereruption periods. Prevalent noise recorded near volcanic systems is often nearly continuously generated by many overlapping low‐magnitude displacements at depth that can be directly linked to magma, fluid, and volatile transport. This noise contains valuable information about subsurface processes that occur between volcanic eruptions and may provide critical information for mitigating risks from volcanic hazards. We present a new computationally efficient method to comprehensively study temporal and spatial variations in extended, diffuse, low‐magnitude volcano‐tectonic seismicity by applying a back‐projection search algorithm to analyze coherent seismic energy arriving from potential subsurface source locations to available pairs of broadband seismometers. We apply this method to Sierra Negra Volcano for a 2.5‐week study period coinciding with a dike intrusion in June 2010. Through averaging (stacking), the back‐projection algorithm illuminates the most likely source locations of low‐magnitude, high‐frequency volcano‐tectonic seismicity before, during, and after previously identified volcano‐tectonic earthquakes. Our results corroborate known volcano‐tectonic earthquake locations and support the interpretation of a small‐volume dike intrusion at ~5–8 km below sea level along the south‐southeastern flanks of the Sierra Negra caldera in June 2010.
Botanic Garden User Outcomes: A Means-End Investigation

Botanic Garden User Outcomes: A Means-End Investigation Christopher Lee Wassenberg This study explored the outcomes that Leaning Pine Arboretum users experience from visiting the botanic garden. Understanding visitor motivations and benefits has been a focus in the field of outdoor recreation, and the subject of a number of botanic garden and green space visitor studies. Previous studies have found that visiting a botanic garden can serve as a coping strategy for dealing with and reducing life stress (Holbrook, 2010; Kohlleppel, Bradley, & Jacob, 2002; Maller, Townsend, Pryor, Brown, & St Leger, 2005) and that visiting public outdoor green spaces led visitors to experience greater exposure to natural spaces and to have meaningful experiences with others (Burgess, Harrison, & Limb, 1988). This study employed means-end theory (Gutman, 1982) to investigate the link between garden attributes and user outcomes. In-person interviews were conducted with 83 garden visitors during the summer of 2011. Researchers coded the interview data to identify participants’ reported attributes, consequences, and values. Intercoder reliability was conducted to ensure validity of the results. Coded data were entered into the Laddermap (Gengler & Reynolds, 1995) computer software program to be analyzed. Implication matrixes were created to determine the number of times concepts were linked. From the implication matrixes, hierarchical value maps (HVMs) were developed to display the results graphically. HVMs show the strength of links between attributes, consequences, and values, and were used to compare results from different visitor groups
RANK 5 3 2 3 5 9 5 2 Node 6 Node 5 Rou ? ng table of Node 6 Internet

RPL is the IPv6 routing protocol for low-power and lossy networks (LLNs), standardized by IETF in 2012 as RFC6550. Specifically, RPL is designed to be a simple and interoperable networking protocol for resource-constrained devices in industrial, home, and urban environments, intended to support the vision of the Internet of Things (IoT) with thousands of devices interconnected through multihop mesh networks. More than four-years have passed since the standardization of RPL, and we believe that it is time to examine and understand its current state. In this article, we review the history of research efforts in RPL; what aspects have been (and have not been) investigated and evaluated, how they have been studied, what was (and was not) implemented, and what remains for future investigation. We reviewed 97+ RPL-related academic research papers published by major academic publishers and present a topic-oriented survey for these research efforts. Our survey shows that only 40.2% of the papers evaluate RPL through experiments using implementations on real embedded devices, ContikiOS and TinyOS are the two most popular implementations (92.3%), and TelosB was the most frequently used hardware platform (69%) on testbeds that have average and median size of 49.4 and 30.5 nodes, respectively. Furthermore, unfortunately, despite it being approximately four years since its initial standardization, we are yet to see wide adoption of RPL as part of real-world systems and applications. We present our observations on the reasons behind this and suggest directions on which RPL should evolve.
Non-invasive Ventilation for Acute Respiratory Failure

Giant steps are what Non-Invasive Mechanical Ventilation (NIMV) has taken in the last decades for the treatment of Acute Respiratory Failure. NIMV is safe and effective when applied early to carefully selected patients not meeting criteria for invasive ventilation. A well-fitting interface, close monitoring, coaching and clear information provided to patients, and a trained and skilled team available throughout the 24-h period are crucial factors to get to the best outcome, to reduce morbility and mortality associated to endotracheal intubation. Moving from the essential questions, in this review we focused on the key points to know and understand NIMV in some lights and shadows. What is NIMV and what do we mean speaking about NIMV? Which kind of NIMV is it suitable? Why NIMV works? Who is the right patient, and who is the right doctor, for NIMV? When to start NIMV? Where to perform NIMV? How to carry out NIMV? How long to go on with NIMV?
Temporal trends in the use of anticoagulants among older adults with atrial fibrillation.

BACKGROUND Several recent randomized clinical trials have demonstrated that warfarin sodium treatment, and to a lesser extent aspirin, reduces risk of stroke and death compared with placebo in persons with atrial fibrillation. Insufficient documentation exists on the extent to which the use of these therapies following trial publications has continued to increase in the elderly with atrial fibrillation. METHODS We used data from the Cardiovascular Health Study, a study of 5888 community-dwelling adults aged 65 years or older, to determine the prevalence of warfarin and aspirin use in persons with electrocardiogram-identified atrial fibrillation. Electrocardiogram examinations were conducted at baseline from 1989 through 1990, and at 6 subsequent annual examinations through 1995-1996. Medication data were collected by inventory methods at each examination. Temporal change in use of anticoagulants was analyzed by comparing percentage use in 1990 to use in each year through 1996. RESULTS The use of warfarin increased 4-fold from 13% in 1990 to 50% in 1996 among participants with prevalent atrial fibrillation (P<.001). Daily use of aspirin did not increase over time. Participants younger than 80 years were 4 times more likely to use warfarin in 1996 (P<.001) than those 80 years and older. Use of aspirin did not vary significantly with age. CONCLUSIONS Warfarin use in community-dwelling elderly persons with electrocardiogram-documented atrial fibrillation increased steadily following the first publication of its treatment benefit, reaching 50% by 1996. In contrast, use of aspirin was unchanged during this same period. Continued efforts to promote appropriate anticoagulation therapy to physicians and their patients may still be needed.
Evaluation of Midkine as a Diagnostic Serum Biomarker in Hepatocellular Carcinoma

Purpose: To evaluate the value of serum midkine (MDK) as a diagnostic biomarker in hepatocellular carcinoma, particularly for those with negative alpha-fetoprotein (AFP) and at an early stage. Experimental Design: MDK expression in tumors was assessed by immunohistochemistry from 105 patients with hepatocellular carcinomas or liver cirrhosis. Serum MDK levels were detected by ELISA in 933 participants including hepatocellular carcinomas and hospital controls from different medical centers. Sensitivities and specificities of serum MDK in diagnosing hepatocellular carcinoma according to AFP level and Barcelona Clinic Liver Cancer (BCLC) stage were analyzed. Results: MDK levels were significantly elevated in hepatocellular carcinoma tissues as well as serum samples. The sensitivity of serum MDK for hepatocellular carcinoma diagnosis was much higher than that of AFP (86.9% vs. 51.9%) with similar specificities (83.9% vs. 86.3%). Notably, serum MDK had an outstanding performance in distinguishing AFP-negative hepatocellular carcinomas from different controls: In those AFP-negative hepatocellular carcinomas, the sensitivity could reach as high as 89.2%. Moreover, receiver operating characteristic (ROC) curve analysis also showed that serum MDK had a better performance compared with AFP in distinguishing early-stage hepatocellular carcinomas as well as small hepatocellular carcinomas. Even in very early-stage hepatocellular carcinomas, MDK showed an obviously higher sensitivity compared with AFP (80% vs. 40%). Furthermore, serum MDK level was significantly decreased in patients with hepatocellular carcinomas after curative resection and re-elevated when tumor relapse occurred. Conclusions: Serum MDK is significantly elevated in most hepatocellular carcinomas, including those with negative AFP and at an early stage, which may serve as a novel diagnostic marker in early diagnosis and postoperative monitoring of hepatocellular carcinomas. Clin Cancer Res; 19(14); 3944–54. ©2013 AACR.
Discharge height of lightning narrow bipolar events

[1] Discharge heights of thousands of narrow bipolar events (NBEs) observed in Guangzhou and Chongqing of China are calculated using time delays between the direct wave signals of NBEs and their ionospheric reflection pairs. The result shows that most positive NBEs occur between 8 and 16 km while most negative NBEs occur between 16 and 19 km. Very few negative NBEs are above 19 km or below 14 km. It is inferred that positive NBEs are produced between main negative charge layer and upper positive charge layer while negative NBEs are produced between upper positive charge layer and negative screening charge layer at the cloud top. Variations of NBE discharge heights in two thunderstorms are analyzed. It seems that NBEs can be produced at any position between corresponding charge layers. Positive NBEs are generally higher in the periods when negative NBEs are also occurring. For a given short time period in a single thunderstorm, negative NBEs are always observed to occur at a higher altitude than positive NBEs, indicating a dividing charge layer between positive NBEs and negative NBEs. The possibility of some NBEs as upward discharges from cloud tops mentioned by previous studies is discussed. Supported by multiple evidences, we believe such possibility is very low; instead, NBEs are produced in vigorous convective surges that develop to the height comparable to the discharge height of NBEs. Differences in height distributions in Guangzhou and Chongqing are analyzed and a hypothesis is put forward that both positive NBEs and negative NBEs can only be produced above certain height. The relationship between this hypothesis and the mechanism for NBE production is discussed.
Welfare and Bond Pricing Implications of Fiscal Stabilization Policies

How do cyclical fiscal stabilisation policies affect welfare and government bond risk premia? Using a new Keynesian model we find that the effects of fiscal policy rules on the bond premium and welfare crucially depend on the source of business cycle fluctuations. The overall effect is estimated using Bayesian methods and the mechanism is deconstructed by examining the propagation mechanism of the different shocks. We find that the impact of fiscal policy cyclicality on welfare and risk premia is highly non-linear and that these effects are of a policy relevant magnitude. Finally, we find that the welfare cost of highly procyclical fiscal policies are very large, but also excessive fiscal stabilization can generate non-negligible welfare losses.
Does APO ε4 correlate with MRI changes in Alzheimer's disease?

OBJECTIVE To assess the relation between APO E genotype and MRI white matter changes in Alzheimer's disease. The APO ε4 allele is correlated with amyloid angiopathy and other neuropathologies in Alzheimer's disease and could be associated with white matter changes. If so, there should be a dose effect. METHODS 104 patients with probable Alzheimer's disease (NINCDS-ADRDA criteria) in this Alzheimer's Disease Research Centre were studied. Patients received MRI and APO E genotyping by standardised protocols. Axial MRI was scored (modified Schelten's scale) for the presence and degree of white matter changes and atrophy in several regions by a neuroradiologist blinded to genotype. Total white matter and total atrophy scores were also generated. Data analysis included Pearson's correlation for regional and total imaging scores and analysis of variance (ANOVA) (or Kruskal-Wallis) and χ2 for demographic and disease related variables. RESULTS 30 patients had no ε4, 53 patients were heterozygous, and 21 patients were homozygous. The three groups did not differ in sex distribution, age of onset, age at MRI, MMSE, clinical dementia rating, or modified Hachinski ischaemia scores. There were no significant correlations between total or regional white matter scores and APO E genotype (Pearson correlation). CONCLUSIONS No correlation between total or regional white matter scores and APO E genotype was found. The pathogenesis of white matter changes in Alzheimer's disease may be independent of APO E genotype.