Miracle-dz/UniFAR-FTUs huggingface dataset:
Three new potential ovarian cancer biomarkers detected in human urine with equalizer bead technology

Objective. To examine whether urine can be used to measure specific ovarian cancer proteomic profiles and whether one peak alone or in combination with other peaks or CA125 has the sensitivity and specificity to discriminate between ovarian cancer pelvic mass and benign pelvic mass. Methods. A total of 209 women were admitted for surgery for pelvic mass at the Gynaecological Department at Rigshospitalet, Copenhagen. Of the women, 156 had benign gynaecological tumors, 13 had borderline tumors and 40 had malignant epithelial ovarian cancer. The prospectively and preoperatively collected urine samples were aliquotted and frozen at −80° until the time of analysis. The urine was fractionated using equalizer bead technology and then analyzed with surface‐enhanced laser desorption/ionization time‐of‐flight mass spectrometry. Biomarkers were purified and identified using combinations of chromatographic techniques and tandem mass spectrometry. Results. Benign and malignant ovarian cancer cases were compared; 21 significantly different peaks (p<0.001) were visualized using Mann–Whitney analysis, ranging in m/z values from 1,500 to 185,000. The three most significant peaks were purified and identified as fibrinogen alpha fragment (m/z = 2570.21), collagen alpha 1 (III) fragment (m/z = 2707.32) and fibrinogen beta NT fragment (m/z = 4425.09). The area under the receiver operator characteristic curve (ROC AUC) value for these three peaks in combination was 0.88, and their ROC AUC value in combination with CA125 was 0.96. Conclusion. This result supports the feasibility of using urine as a clinical diagnostic medium, and the ROC AUC value for the three most significant peaks in combination with or without CA125 demonstrates the enhanced prediction performance of combined marker analysis.
Counselors' Experiences With Problematic Dual Relationships

The British Columbian members of the Canadian Guidance and Counselling Association were surveyed to explore their attitudes regarding dual relationships. Of 529 deliverable surveys, 206 usable returns yielded a response rate of 39%. Participants were asked to provide incidents of problematic dual relationships and to discuss the problematic aspect(s) of these dual relationships. Respondents provided a total of 110 useable incidents with 165 associated problematic aspects. Many respondents provided data not directly related to the original questions, which were also analyzed. The results of this study draw attention to several issues: (a) counselors are dealing with a variety of problematic dual relationships, (b) counselors experience discomfort and negative effects on their personal/work life secondary to these dual relationships, and (c) counselors consider the unique context of each dual relationship to be important in their ethical decision-making processes.
Mai dongxi: Social influence, materialism and China's one-child policy

This paper investigates the moderating role of the China's one-child policy on the relationship between susceptibility to social influence from parents and peers and the levels of materialism of consumers. By comparing Chinese consumers who were born after the implementation of the one-child policy with their Indian and Thai counterparts, our study finds that the previously documented positive relationship between peer influence and materialism as well as the negative relationship between parental influence and materialism are greater for consumers from China than those from India and Thailand. We theorize that these differences are due to the ability and motivation of only-children to internalize the materialistic values from their parents and peers. Further, we demonstrate that these differences in social influence are restricted to in-group influences (i.e., parents and peers) and do not manifest in the case of out-group influences (e.g., salespeople).
Hiding in Plain Sight

Terrorism is behavior that is both initiated and sustained by actors within a social environment. That social environment may vary along a continuum from supporting and enabling the behavior, to ignoring or being unaware of the behavior, to actively opposing the behavior. This article applies social disorganization theory, social capital theory and Black's work on terrorism to predict community characteristics likely to provide the anonymity required for the development of terrorist activity in developed nations. Using the Social Capital Community Benchmark Survey and case studies, the article demonstrates how the theory predicts and helps explain why the 9/11 terrorists went undetected even as they lived in the US.
Precarious lives, precarious labour: family support and young men's transitions to work in the UK

This research is about young people, family support and transitions into the workforce. We provide the results of a comparative, qualitative study with young men in two southern English towns. We argue that relationships of support in families are vital to young people's ability to ‘navigate’ precarious labour market opportunities. As Youth Studies has become increasingly preoccupied with individualism, we are compelled to draw attention to the collective support that is necessary to ‘launch’ the life trajectories of young people who are transitioning into an economic environment marked by insecurity and uncertainty. We conclude with recommendations for future research.
Exogenous enzyme improves immunocompetence in laying hens fed diets containing safflower meal.

An experiment was conducted to study the effects of different levels of exogenous enzymes on egg quality characteristics and immunological responses of laying hens fed diets containing different levels of safflower meal. The 47-week old layers (Hy-Line W-36) were fed 10 experimental diets consisting five levels of safflower meal (0.0, 2.5, 5.0, 7.5 and 10.0%) and two levels of dietary exogenous enzyme (0.0 and 0.1% Bergazym P) during the experimentation. The trial period lasted for a total of 10 weeks, and egg quality indices were measured as two 35 day experimental periods. After 48 and 55 days of experiment, birds were injected with 1 mL of 7% Sheep Red Blood Cells (SRBC) intramuscularly. At the end of experiment, the antibody titer against SRBC and differential circulating leukocyte count were measured for investigating immune status. Least squares mean analysis showed that although the inner egg quality characteristics (yolk index and Haugh unit) were not influenced by dietary treatments, using the highest level of safflower meal caused remarkable decrease in eggshell weight and strength during the first 35-day experimental period. Nonetheless, these parameters showed tendency to decrease during the second trial period. The heterophils to lymphocytes ratio were significantly increased after feeding different levels of safflower meal and reach to the highest level in hens fed diet containing 10% of this meal. This response was due to the increase in heterophils population and contemporaneous decrease in lymphocytes percentage. Inclusion of 0.1% dietary enzyme had remarkable modulatory effect on heterophils count and the heterophils to lymphocytes ratio. Following the administration of dietary enzymes, the number of lymphocytes and thereby, the primary humoral immunity response increased significantly, however, this alteration had tendency to increase during the secondary immunity response against SRBS. Therefore, our results indicated that using high level of safflower meal (10%) in laying hens diet could have aversive effects on eggshell quality. Also, administration of dietary exogenous enzyme to the diets of laying hens would have beneficial effects on immunological responses, especially in terms of heterophil to lymphocyte ratio depression or improvement of humoral immunological functions
Transmission of arterial oxygen partial pressure oscillations to the cerebral microcirculation in a porcine model of acute lung injury caused by cyclic recruitment and derecruitment.

BACKGROUND Cyclic recruitment and derecruitment (R/D) play a key role in the pathomechanism of acute lung injury (ALI) leading to respiration-dependent oscillations of arterial partial pressure of oxygen (Pa(O(2))). These Pa(O(2)) oscillations could also be forwarded to the cerebral microcirculation. METHODS In 12 pigs, partial pressure of oxygen was measured in the thoracic aorta (Pa(O(2))) and subcortical cerebral tissue (Pbr(O(2))). Cerebral cortical haemoglobin oxygen saturation (Sbr(O(2))), cerebral blood flow (CBF), and peripheral haemoglobin saturation (Sp(O(2))) were assessed by spectroscopy and laser Doppler flowmetry. Measurements at different fractions of inspired oxygen (F(I(O(2)))) were performed at baseline and during cyclic R/D. STATISTICS frequency domain analysis, the Mann-Whitney test, linear models to test the influence of Pa(O(2)) and systolic arterial pressure (SAP) oscillations on cerebral measurements. RESULTS Parameters [mean (SD)] remained stable during baseline. Pa(O(2)) oscillations [10.6 (8) kPa, phase(reference)], systemic arterial pressure (SAP) oscillations [20 (9) mm Hg, phase(Pa(O(2))-SAP) -33 (72)°], and Sp(O(2))oscillations [1.9 (1.7)%, phase(Pa(O(2))-Sp(O(2))) 264 (72)°] were detected during lung R/D at 1.0. Pa(O(2)) oscillations decreased [2.7 (3.5) kPa, P=0.0008] and Sp(O(2)) oscillations increased [6.8 (3.9)%, P=0.0014] at F(I(O(2))) 0.3. In the brain, synchronized Pbr(O(2)) oscillations [0.6 (0.4) kPa, phase(Pa(O(2))-Pbr(O(2))) 90 (39)°], Sbr(O(2)) oscillations [4.1 (1.5)%, phase(Pa(O(2))-Sbr(O(2))) 182 (54)°], and CBF oscillations [198 (176) AU, phase(Pa(O(2))-CBF) 201 (63)°] occurred that were dependent on Pa(O(2)) and SAP oscillations. CONCLUSIONS Pa(O(2)) oscillations caused by cyclic R/D are transmitted to the cerebral microcirculation in a porcine model of ALI. These cyclic oxygen alterations could play a role in the crosstalk of acute lung and brain injury.
In Vivo Corrosion of Two Novel Magnesium Alloys ZEK100 and AX30 and Their Mechanical Suitability as Biodegradable Implants

In magnesium alloys, the components used modify the alloy properties. For magnesium implants in contact with bone, rare earths alloys are commonly examined. These were shown to have a higher corrosion resistance than other alloys and a high mechanical strength, but their exact composition is hard to predict. Therefore a reduction of their content could be favorable. The alloys ZEK100 and AX30 have a reduced content or contain no rare earths at all. The aim of the study was to investigate their in vivo degradation and to assess the suitability of the in vivo µCT for the examination of their corrosion. Implants were inserted in rabbit tibiae. Clinical examinations, X-rays and in vivo µCT scans were done regularly. Afterwards implants were analyzed with REM, electron dispersive X-ray (EDX), weighing and mechanical testing. The in vivo µCT is of great advantage, because it allows a quantification of the corrosion rate and qualitative 3D assessment of the corrosion morphology. The location of the implant has a remarkable effect on the corrosion rate. Due to its mechanical characteristics and its corrosion behavior, ZEK100 was judged to be suitable, while AX30, which displays favorable degradation behavior, has too little mechanical strength for applications in weight bearing bones.
Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs.

We investigated whether rimonabant, a type 1 cannabinoid receptor antagonist, reduces visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in dogs maintained on a hypercaloric high-fat diet (HHFD). To determine whether energy expenditure contributed to body weight changes, we also calculated resting metabolic rate. Twenty male dogs received either rimonabant (1.25 mg.kg(-1). day(-1), orally; n = 11) or placebo (n = 9) for 16 wk, concomitant with a HHFD. VAT, SAT, and nonfat tissue were measured by magnetic resonance imaging. Resting metabolic rate was assessed by indirect calorimetry. By week 16 of treatment, rimonabant dogs lost 2.5% of their body weight (P = 0.029), whereas in placebo dogs body weight increased by 6.2% (P < 0.001). Rimonabant reduced food intake (P = 0.027), concomitant with a reduction of SAT by 19.5% (P < 0.001). In contrast with the VAT increase with placebo (P < 0.01), VAT did not change with rimonabant. Nonfat tissue remained unchanged in both groups. Body weight loss was not associated with either resting metabolic rate (r(2) = 0.24; P = 0.154) or food intake (r(2) = 0.24; P = 0.166). In conclusion, rimonabant reduced body weight together with a reduction in abdominal fat, mainly because of SAT loss. Body weight changes were not associated with either resting metabolic rate or food intake. The findings provide evidence of a peripheral effect of rimonabant to reduce adiposity and body weight, possibly through a direct effect on adipose tissue.
Direct and Indirect Effects of Newlywed Couples' Neuroticism and Stressful Events on Marital Satisfaction Through Mutual Problem Solving

This investigation examined the role of neuroticism, stressful experiences, and mutual problem solving in newlywed couples' marital satisfaction. The vulnerability-stress-adaptation model of marital development was used as the basis of the proposed hypotheses. Dyadic analyses and tests of indirect effects were performed on data from 186 couples in the first 5 years of their marriage. Results indicate that husbands' and wives' work, job–home interference, and family stress were significantly associated with their own lower marital satisfaction. Significant partner effects further indicated that husbands' and wives' family stress was negatively associated with the marital satisfaction of their partner. Additionally, the relationships between (1) neuroticism and marital satisfaction and (2) stressful events and marital satisfaction can be partially explained by mutual problem solving for both husbands and wives. This study emphasizes the important role of problem-solving communication in newlywed couples' experiences of stressful events and marital satisfaction.
The Selective Impairment of the Phonological Output Buffer: Evidence From a Chinese Patient

We present a Chinese-speaking patient, SJ, who makes phonological errors across all tasks involving oral production. Detailed analyses of the errors across different tasks reveal that the patterns are very similar for reading, oral picture naming, and repetition tasks, which are also comparable to the error patterns of the phonological buffer deficit cases reported in the literature. The nature of the errors invites us to conclude that the patient's phonological output buffer is selectively impaired. Different from previously reported cases, SJ's deficits in oral production tasks are not accompanied by a similar impairment of writing performance. We argue that this dissociation is evidence that the phonological output buffer is not involved in writing Chinese words. Furthermore, the majority of SJ's errors occur at the onset of a syllable, indicating that the buffer has a structure that makes the onset more prone to impairment.
Análisis comparativo de confiabilidad y validez de dos escalas de anomia

A comparative psychometric study of validity and reliability was made for the Anomie’s Srole scale and Anomy’s McClosky and Schaar scale. The reliability of the scales was carrying out by parallel forms and internal consistence methods. For validity was made a content validity, criterion validity and construct validity analysis. The results show that McClosky and Schaar’s scale had a best performance than Srole’s scale in the sample. In spite of this Srole’s scale can be used following a set of recommendations.
Are negative aspects of social relations predictive of angina pectoris? A 6-year follow-up study of middle-aged Danish women and men

Background Social relations have been shown to be protective against ischaemic heart disease (IHD), but little is known about the impact of negative aspects of the social relations on IHD. Methods During a 6-year follow-up, the authors aimed to assess if negative aspects of social relations were associated with angina pectoris among 4573 middle-aged Danish men and women free of heart disease at baseline in 2000. Results Nine per cent experienced onset of symptoms of angina pectoris. A higher degree of excessive demands or worries from the social relations was associated with increased risk of angina after adjustment for age, gender, social class, cohabitation status and depression in a dose–response manner. For example, experiencing excessive demands or worries always/often from different roles in the social relations was associated with an increased risk: partner OR=3.53 (1.68 to 7.43), children OR=2.19 (1.04 to 4.61), other family OR=1.91 (1.24 to 2.96). Except for frequent conflicts with the partner and neighbours, conflicts with the social relations was not a risk factor for angina. The authors found no interaction of negative aspects of social relations with gender, age, social class, cohabitation status or depression in terms of angina. Conclusion Excessive demands and serious worries from significant others seem to be important risk factors for development of angina pectoris.
Student-Centered Instruction: Involving Students in Their Own Education

Learning by Doing Student-centered instruction is a form of active learning where students are engaged and involved in what they are studying. In the United States, this concept was first described around 1900 in the context of con structivism. As a teaching method, construc tivism goes back to at least the work of edu cation reformer John Dewey and Russian developmental psychologist Lev Vygotsky. According to one definition, constructivism states that students learn more by doing and experiencing rather than by observing.1 If, for example, one wants to learn about the saxophone, he or she will learn more by play ing the saxophone than by listening to and reading about the saxophone. Educators Jacqueline Grennon Brooks and Martin G. Brooks describe the value of allowing student responses to steer lessons and create instruc tional strategies. They recommend asking questions and leading students to solutions rather than simply giving answers, with the goal of nurturing students' natural curiosity.2 Put simply, student-centered instruction is when the planning, teaching, and assessment revolve around the needs and abilities of the students. The teacher shares control of the classroom, and students are allowed to explore, experiment, and discover on their own. This does not mean that the students are in control of the classroom, but rather that they have some influence in the deci
Weak lensing survey of galaxy clusters in the CFHTLS Deep

Aims. We present a weak lensing search of galaxy clusters in the 4 deg 2 of the CFHT Legacy Survey Deep. This work aims at building a mass-selected sample of clusters with well controlled selection effects. This present survey is a preliminary step toward a full implementation in the forthcoming 170 deg 2 of the CFHTLS Wide survey. Methods. We use the deep i' band images observed under subarcsecond seeing conditions to perform weak lensing mass reconstructions and to identify high convergence peaks. Thanks to the availability of deep u'g'r'i'z' exposures, sources are selected from their photometric redshifts in the weak lensing analysis. We also use lensing tomography to derive an estimate of the lens redshift. After considering the raw statistics of peaks we check whether they can be associated to a clear optical counterpart or to published X-ray selected clusters. Results. Among the 14 peaks found above a signal-to-noise detection threshold v = 3.5, nine are secure detections with estimated redshift 0.1 ≤ z i ≤ 0.7 and a velocity dispersion 450 ≤ σ v S 700 km s -1 . This low mass range is accessible thanks to the high density of background sources. Considering the intersection between the shear-selected clusters and XMM-LSS X-ray clusters in the Dl field, we observe that the ICM gas in these low-mass clusters (T x ∼ 1-2 keV) is not hotter than the temperature inferred from shear, this trend being different for published massive clusters. A more extended weak lensing survey, with higher statistics of mass structures will be a promising way to bypass several of the problems related to standard detection methods based on the complex physics of baryons.
The Effect of Scoring Instructions and Degree of Speededness on the Validity and Reliability of Multiple-Choice Tests1

In a recent study, Traub, Hambleton, and Singh (1969) compared the effects of two scoring instructions-one promising a small reward for omitted questions, the other threatening a small penalty for wrong answers-on the performance of a multiple-choice vocabulary test. It was found that the reward instruction produced fewer incorrect answers, more omitted questions, and, with one qualification, higher reliability than the penalty instruction. The qualification was that the difference in reliability coefficients for the two instructions was significant at the . 05 level when the performance
Interferon beta modulates endothelial damage in patients with cardiac persistence of human parvovirus b19 infection.

BACKGROUND In a phase 1 study, we investigated whether interferon beta reduced endothelial damage in patients with cardiac persistence of human parvovirus B19 (B19V) infection. METHODS AND RESULTS In vitro, B19V infected cultivated endothelial cells (ECs), which led to a reduction in their viability (P = .007). Interferon beta suppressed B19V replication by 63% (P = .008) in ECs and increased their viability (P = .021). Circulating mature apoptotic ECs (CMAECs [CD45(-)CD146(+) cells expressing von Willebrand factor and annexin V]) and circulating progenitor cells (CPCs [CD34(+)KDR(+) cells]) were quantified by flow cytometry in 9 symptomatic patients with cardiac B19V infection before and after 6 months of interferon beta therapy (16 MU) and were compared to levels in 9 healthy control subjects. Endothelial dysfunction was measured using flow-mediated dilatation of the forearm. Patients with B19V persistence had significantly higher (P = .04) levels of CMAECs than did control subjects, which normalized after treatment (mean +/- standard deviation, 0.06% +/-0.08% vs 0.01% +/- 0.006%; P = .008). Similar improvement was shown for flow-mediated dilatation (P = .04) in the treatment group only (P = .017 for the comparison with untreated patients with B19V persistence n = 5). There were significantly higher numbers of CPCs in patients with B19V persistence before therapy (mean +/- standard deviation, 0.04% +/- 0.05% vs 0.01% +/- 0.004%; P = .02; than in control subjects, which normalized after treatment (P = .03). CONCLUSION Thus, we present (for the first time, to our knowledge) a modulation of virally induced chronic endothelial damage-specifically, EC apoptosis and endothelial regeneration.