Miracle-dz/UniFAR-FTUs huggingface dataset:
We fought tooth and toenail: exploring the dynamics of romantic relationships among sex offenders who have desisted

Abstract Recent research into desistance processes in criminology has identified various explanations and factors in the decision to end criminal careers. One of these life events, shown to generally promote desistance, has been the presence of a romantic relationship. In this study, we argue that research into the role of romantic relationships in sex crime desistance has overlooked the context of romantic relationships, especially pertaining to the quality of relationships. We analyzed interviews with 25 desisting sex offenders, who have returned to the community, to determine how relationship quality varies over time for desisters. Also, we identified themes in the romantic relationships of desisters relative to their conviction (i.e. pre-conviction vs. post-conviction). These findings provide early evidence of the variation in relationship quality amongst sex crime desisters, as well as the impact that relationship quality has on desisters. We conclude that future research in sex crime desistance processes should include relationship quality, not just the presence of a romantic relationship.
De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices

Background Estrogen, a class of female sex steroids, is neuroprotective. Estrogen is synthesized in specific areas of the brain. There is a possibility that the de novo synthesized estrogen exerts protective effect in brain, although direct evidence for the neuroprotective function of brain-synthesized estrogen has not been clearly demonstrated. Methylmercury (MeHg) is a neurotoxin that induces neuronal degeneration in the central nervous system. The neurotoxicity of MeHg is region-specific, and the molecular mechanisms for the selective neurotoxicity are not well defined. In this study, the protective effect of de novo synthesized 17β-estradiol on MeHg-induced neurotoxicity in rat hippocampus was examined. Methodology/Principal Findings Neurotoxic effect of MeHg on hippocampal organotypic slice culture was quantified by propidium iodide fluorescence imaging. Twenty-four-hour treatment of the slices with MeHg caused cell death in a dose-dependent manner. The toxicity of MeHg was attenuated by pre-treatment with exogenously added estradiol. The slices de novo synthesized estradiol. The estradiol synthesis was not affected by treatment with 1 µM MeHg. The toxicity of MeHg was enhanced by inhibition of de novo estradiol synthesis, and the enhancement of toxicity was recovered by the addition of exogenous estradiol. The neuroprotective effect of estradiol was inhibited by an estrogen receptor (ER) antagonist, and mimicked by pre-treatment of the slices with agonists for ERα and ERβ, indicating the neuroprotective effect was mediated by ERs. Conclusions/Significance Hippocampus de novo synthesized estradiol protected hippocampal cells from MeHg-induced neurotoxicity via ERα- and ERβ-mediated pathways. The self-protective function of de novo synthesized estradiol might be one of the possible mechanisms for the selective sensitivity of the brain to MeHg toxicity.
Isospectral deformations of the Dirac operator

We give more details about an integrable system in which the Dirac operator D=d+d^* on a finite simple graph G or Riemannian manifold M is deformed using a Hamiltonian system D'=[B,h(D)] with B=d-d^* + i b. The deformed operator D(t) = d(t) + b(t) + d(t)^* defines a new exterior derivative d(t) and a new Dirac operator C(t) = d(t) + d(t)^* and Laplacian M(t) = d(t) d(t)^* + d(t)* d(t) and so a new distance on G or a new metric on M.
Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis

Recent research has demonstrated that infection with the bacterial pathogen Helicobacter pylori is less common amongst patients with multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS). We aimed to compare the prevalence of H. pylori amongst MS patients and healthy controls, and also investigated the impact of this infection on an animal model for MS, experimental autoimmune encephalomyelitis (EAE). The H. pylori status of 71 MS patients and 42 healthy controls was determined by serology. Groups of C57BL/6 mice were infected with H. pylori, or given diluent alone as a placebo, prior to inducing EAE. Clinical scores were assessed for all mice, and spleens and spinal cord tissue were harvested. CD4+ T cell subsets were quantified by flow cytometry, and T cell proliferation assays were performed. In MS patients the seroprevalence of H. pylori was half that of healthy controls (p = 0.018). Over three independent experiments, prior H. pylori infection had a moderate effect in reducing the severity of EAE (p = 0.012). In line with this, the antigen-specific T cell proliferative responses of infected animals were significantly reduced (p = 0.001), and there was a fourfold reduction in the number of CD4+ cells in the CNS. CD4+ populations in both the CNS and the spleens of infected mice also contained greatly reduced proportions of IFNγ+, IL-17+, T-bet+, and RORγt+ cells, but the proportions of Foxp3+ cells were equivalent. There were no differences in the frequency of splenic CD4+cells expressing markers of apoptosis between infected and uninfected animals. H. pylori was less prevalent amongst MS patients. In mice, the infection exerted some protection against EAE, inhibiting both Th1 and Th17 responses. This could not be explained by the presence of increased numbers of Foxp3+ regulatory T cells, or T cell apoptosis. This is the first direct experimental evidence showing that H. pylori may provide protection against inflammatory demyelination in the CNS.
Active damping of LCL-filter resonance based on virtual resistor for PWM rectifiers — stability analysis with different filter parameters

This publication presents the investigation of active damping of resonance oscillations with virtual resistor for grid-connected PWM rectifiers with LCL-filter for different filter parameters. Using the voltage-oriented PI current control with converter current feedback, additional active damping of the filter resonance is necessary for stable operation. In the literature different methods are proposed that differ in number of sensors and complexity of control algorithms. If higher damping of the switching ripple current is required LCL-filters with lower resonance frequencies can be used. Resulting low ratios between resonance frequency and control frequency challenge the control with respect to damping of resonance. Moreover, some active damping methods are not suitable for these filter settings. Here the active damping concept based on virtual resistor is analyzed concerning stability for two significant filter configurations. It turns out that it is applicable for configurations with higher resonance frequency, whereas systems lower resonance frequencies can poorly be damped. Additionally the method exhibits the advantage of simple implementation but the disadvantage of additional current sensors. Theoretical analyses and of the selected method with time-discrete implementation are shown in this paper. Theory is verified by experimental results.
Intracerebral Administration of Recombinant Rabies Virus Expressing GM-CSF Prevents the Development of Rabies after Infection with Street Virus

Recently it was found that prior immunization with recombinant rabies virus (RABV) expressing granulocyte-macrophage colony-stimulating factor (GM-CSF) (LBNSE-GM-CSF) resulted in high innate/adaptive immune responses and protection against challenge with virulent RABV (Wen et al., JVI, 2011). In this study, the ability of LBNSE-GM-CSF to prevent animals from developing rabies was investigated in mice after infection with lethal doses of street RABV. It was found that intracerebral administration of LBNSE-GM-CSF protected more mice from developing rabies than sham-treated mice as late as day 5 after infection with street RABV. Intracerebral administration of LBNSE-GM-CSF resulted in significantly higher levels of chemokine/cytokine expression and more infiltration of inflammatory and immune cells into the central nervous system (CNS) than sham-administration or administration with UV-inactivated LBNSE-GM-CSF. Enhancement of blood-brain barrier (BBB) permeability and increases in virus neutralizing antibodies (VNA) were also observed in mice treated with LBNSE-GM-CSF. On the other hand, intracerebral administration with UV-inactivated LBNSE-GM-CSF did not increase protection despite the fact that VNA were induced in the periphery. However, intracerebral administration with chemoattractant protein-1 (MCP-1, also termed CCL2) increased significantly the protective efficacy of UV-inactivated LBNSE-GM-CSF. Together these studies confirm that direct administration of LBNSE-GM-CSF can enhance the innate and adaptive immunity as well as the BBB permeability, thus allowing infiltration of inflammatory cells and other immune effectors enter into the CNS to clear the virus and prevent the development of rabies.
Gender-Specificity of Initial and Controlled Visual Attention to Sexual Stimuli in Androphilic Women and Gynephilic Men

Research across groups and methods consistently finds a gender difference in patterns of specificity of genital response; however, empirically supported mechanisms to explain this difference are lacking. The information-processing model of sexual arousal posits that automatic and controlled cognitive processes are requisite for the generation of sexual responses. Androphilic women’s gender-nonspecific response patterns may be the result of sexually-relevant cues that are common to both preferred and nonpreferred genders capturing attention and initiating an automatic sexual response, whereas men’s attentional system may be biased towards the detection and response to sexually-preferred cues only. In the present study, we used eye tracking to assess visual attention to sexually-preferred and nonpreferred cues in a sample of androphilic women and gynephilic men. Results support predictions from the information-processing model regarding gendered processing of sexual stimuli in men and women. Men’s initial attention patterns were gender-specific, whereas women’s were nonspecific. In contrast, both men and women exhibited gender-specific patterns of controlled attention, although this effect was stronger among men. Finally, measures of attention and self-reported attraction were positively related in both men and women. These findings are discussed in the context of the information-processing model and evolutionary mechanisms that may have evolved to promote gendered attentional systems.
Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway.

BACKGROUND Prostaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma. METHODS This study investigated fibroblast growth factor 2 (FGF2) mRNA expression and cell signalling in response to seminal plasma or PGE(2), using an endometrial adenocarcinoma (Ishikawa) cell line stably expressing the EP2 receptor (EP2 sense cells) and endometrial adenocarcinoma explants. RESULTS Seminal plasma and PGE(2) induced a significant up-regulation of FGF2 expression in EP2 sense but not parental untransfected Ishikawa (wild-type) cells (P < 0.05). These effects were inhibited by co-treatment with EP2 receptor antagonist or inhibitors of protein kinase A, c-Src, epidermal growth factor receptor (EGFR) kinase or extracellular signal-regulated kinase (ERK) signalling. The treatment of EP2 sense cells with seminal plasma induced cAMP accumulation and phosphorylation of c-Src, EGFR kinase and ERK via the EP2 receptor. Finally, seminal plasma and PGE(2) significantly increased FGF2 mRNA expression in endometrial adenocarcinoma tissue explants via the EP2 receptor (P < 0.05). CONCLUSIONS Seminal plasma and PGE(2) can similarly activate FGF2 expression and EP2 receptor signalling in endometrial adenocarcinoma cells. These data highlight the potential for seminal plasma exposure to facilitate tumorigenesis-angiogenesis in endometrial adenocarcinomas in vivo.
The Advent of Surveillance Realism: Public Opinion and Activist Responses to the Snowden Leaks

The Snowden leaks provided unprecedented insights into the workings of state-corporate surveillance programs based on the interception and collection of online activity. They illustrated the extent of “bulk” data collection and the general and widespread monitoring of everyday communication platforms used by ordinary citizens. Yet public response in the United Kingdom and elsewhere has been considerably muted, and there has been little evidence of public outcry, with often conflicting and inconsistent opinions on the subject. Based on research carried out for the project Digital Citizenship and Surveillance Society, this article explores the nuances of public attitudes toward surveillance, including such attitudes among politically active citizens, through focus groups and interviews. We argue that the lack of transparency, knowledge, and control over what happens to personal data online has led to feelings of widespread resignation, not consent, to the status quo that speaks to a condition we identify as “surveillance realism. ” We understand this to entail a simultaneous unease among citizens with data collection alongside the active normalization of surveillance that limits the possibilities of enacting modes of citizenship and of imagining alternatives.
Pervasive Hitchhiking at Coding and Regulatory Sites in Humans

Much effort and interest have focused on assessing the importance of natural selection, particularly positive natural selection, in shaping the human genome. Although scans for positive selection have identified candidate loci that may be associated with positive selection in humans, such scans do not indicate whether adaptation is frequent in general in humans. Studies based on the reasoning of the MacDonald–Kreitman test, which, in principle, can be used to evaluate the extent of positive selection, suggested that adaptation is detectable in the human genome but that it is less common than in Drosophila or Escherichia coli. Both positive and purifying natural selection at functional sites should affect levels and patterns of polymorphism at linked nonfunctional sites. Here, we search for these effects by analyzing patterns of neutral polymorphism in humans in relation to the rates of recombination, functional density, and functional divergence with chimpanzees. We find that the levels of neutral polymorphism are lower in the regions of lower recombination and in the regions of higher functional density or divergence. These correlations persist after controlling for the variation in GC content, density of simple repeats, selective constraint, mutation rate, and depth of sequencing coverage. We argue that these results are most plausibly explained by the effects of natural selection at functional sites—either recurrent selective sweeps or background selection—on the levels of linked neutral polymorphism. Natural selection at both coding and regulatory sites appears to affect linked neutral polymorphism, reducing neutral polymorphism by 6% genome-wide and by 11% in the gene-rich half of the human genome. These findings suggest that the effects of natural selection at linked sites cannot be ignored in the study of neutral human polymorphism.
Developmental improvement in strategies to maintain verbal information in working memory

Although it has been proposed that maintenance of verbal information in adults’ working memory relies on two strategies, articulatory rehearsal and attentional refreshing, little is known about the interplay of these strategies in children. To examine strategy changes around the age of seven, children were asked to maintain digits during a retention interval introduced between encoding and recall. In Experiment 1, this interval was either unfilled in a delayed span task or filled with an attention-demanding task in a Brown-Peterson task. This concurrent task was either silent or aloud to vary the availability of rehearsal. Experiment 2 introduced variation in the attentional demand of the concurrent task, and an independent concurrent articulation. As predicted, recall performance was better in older children, but was reduced under concurrent articulation or when attention was less available, bringing further evidence in favor of two maintenance strategies. Moreover, the measure of the availability of attention for refreshing was correlated with recall performance in eight- and seven-year-olds, though only when rehearsal was impeded for seven-year-olds, but it did not correlate with six-year-olds’ recall. This could suggest that rehearsal is the default strategy in young children who can adaptively switch to refreshing when articulatory processes are unavailable.
The Wiring of Developing Sensory Circuits—From Patterned Spontaneous Activity to Synaptic Plasticity Mechanisms

In order to accurately process incoming sensory stimuli, neurons must be organized into functional networks, with both genetic and environmental factors influencing the precise arrangement of connections between cells. Teasing apart the relative contributions of molecular guidance cues, spontaneous activity and visual experience during this maturation is on-going. During development of the sensory system, the first, rough organization of connections is created by molecular factors. These connections are then modulated by the intrinsically generated activity of neurons, even before the senses have become operational. Spontaneous waves of depolarizations sweep across the nervous system, placing them in a prime position to strengthen correct connections and weaken others, shaping synapses into a useful network. A large body of work now support the idea that, rather than being a mere side-effect of the system, spontaneous activity actually contains information which readies the nervous system so that, as soon as the senses become active, sensory information can be utilized by the animal. An example is the neonatal mouse. As soon as the eyelids first open, neurons in the cortex respond to visual information without the animal having previously encountered structured sensory input (Cang et al., 2005b; Rochefort et al., 2011; Zhang et al., 2012; Ko et al., 2013). In vivo imaging techniques have advanced considerably, allowing observation of the natural activity in the brain of living animals down to the level of the individual synapse. New (opto)genetic methods make it possible to subtly modulate the spatio-temporal properties of activity, aiding our understanding of how these characteristics relate to the function of spontaneous activity. Such experiments have had a huge impact on our knowledge by permitting direct testing of ideas about the plasticity mechanisms at play in the intact system, opening up a provocative range of fresh questions. Here, we intend to outline the most recent descriptions of spontaneous activity patterns in rodent developing sensory areas, as well as the inferences we can make about the information content of those activity patterns and ideas about the plasticity rules that allow this activity to shape the young brain.
Superlinear Problems

We solve elliptic semilinear boundary value problems in which the nonlinear term is superlinear. By weakening the hypotheses, we are able to include more equations than hitherto permitted. In particular, we do not require the superquadracity condition imposed by most authors, and it is not assumed that the region is bounded.
Face illumination transfer through edge-preserving filters

This article proposes a novel image-based method to transfer illumination from a reference face image to a target face image through edge-preserving filters. According to our method, only a single reference image, without any knowledge of the 3D geometry or material information of the target face, is needed. We first decompose the lightness layers of the reference and the target images into large-scale and detail layers through weighted least square (WLS) filter after face alignment. The large-scale layer of the reference image is filtered with the guidance of the target image. Adaptive parameter selection schemes for the edge-preserving filters is proposed in the above two filtering steps. The final relit result is obtained by replacing the large-scale layer of the target image with that of the reference image. We acquire convincing relit result on numerous target and reference face images with different lighting effects and genders. Comparisons with previous work show that our method is less affected by geometry differences and can preserve better the identification structure and skin color of the target face.
Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells

Interleukin-10 (IL-10) plays an indispensable role in mucosal tolerance by programming dendritic cells (DCs) to induce suppressor Th-cells. We have tested the modulating effect of L. lactis secreting human IL-10 (L. lactis IL-10) on DC function in vitro. Monocyte-derived DC incubated with L. lactis IL-10 induced effector Th-cells that markedly suppressed the proliferation of allogenic Th-cells as compared to L. lactis. This suppressive effect was only seen when DC showed increased CD83 and CD86 expression. Furthermore, enhanced production of IL-10 was measured in both L. lactis IL-10-derived DC and Th-cells compared to L. lactis-derived DC and Th-cells. Neutralizing IL-10 during DC-Th-cell interaction and coculturing L. lactis IL-10-derived suppressor Th-cells with allogenic Th-cells in a transwell system prevented the induction of suppressor Th-cells. Only 130 pg/mL of bacterial-derived IL-10 and 40 times more exogenously added recombinant human IL-10 were needed during DC priming for the generation of suppressor Th-cells. The spatially restricted delivery of IL-10 by food-grade bacteria is a promising strategy to induce suppressor Th-cells in vivo and to treat inflammatory diseases.
Energy and Emissions: Local and Global Effects of the Rise of China and India

Part 1 of the paper reviews recent trends in fossil fuel use and associated externalities. It also argues that the recent run-up in international oil prices reflects growing concerns about supply constraints associated with declining spare capacity in OPEC, refining bottlenecks, and geopolitical uncertainties rather than growing incremental use of oil by China and India. Part 2 compares two business as usual scenarios with a set of alternate scenarios based on policy interventions on the demand for or supply of energy and different assumptions about rigidities in domestic and international energy markets. The results suggest that energy externalities are likely to worsen significantly if there is no shift in China's and India's energy strategies. High energy demand from China and India could constrain some developing countries'growth through higher prices on international energy markets, but for others the"growth retarding"effects of higher energy prices are partially or fully offset by the"growth stimulating"effects of the larger markets in China and India. Given that there are many inefficiencies in the energy system in both China and India, there is an opportunity to reduce energy growth without adversely affecting GDPgrowth. The cost of a decarbonizing energy strategy will be higher for China and India than a fossil fuel-based strategy, but the net present value of delaying the shift will be higher than acting now. The less fossil fuel dependent alternative strategies provide additional dividends in terms of energy security.