Miracle-dz/UniFAR-FTUs huggingface dataset:
Do ratings of African-American cultural competency reflect characteristics of providers or perceivers? Initial demonstration of a generalizability theory approach

Provider cultural competency is often identified as an important component of effective ethnic minority healthcare. However, there is limited knowledge of the manner in which cultural competency judgments operate. This study sought to provide an initial demonstration of a hitherto overlooked methodology for examining the extent to which provider cultural competency ratings reflect characteristics of providers, differences among perceivers, and also idiosyncratic pairings of specific perceivers and providers. Second and third year medical residents rated four attending physicians for cultural competency when treating African-American patients. Using a Generalizability Theory approach, cultural competency ratings were shown to most substantially reflect unique perceiver and provider pairings (47.0% relationship effect). However, cultural competency also strongly reflected differences among resident raters in their tendency to perceive attending physicians as culturally competent, regardless of the characteristics of physicians (35.0% perceiver effect). Although cultural competency significantly reflected the characteristics of providers this effect was small (3.0% provider effect). This study demonstrates an overlooked methodological approach and suggests important new directions for conceptualizing theory and research.
Longitudinal Characterization of [18F]-FDG and [18F]-AV45 Uptake in the Double Transgenic TASTPM Mouse Model

We aimed to monitor the timing of amyloid-β deposition in relation to changes in brain function using in vivo imaging with [18F]-AV45 and [18F]-FDG in a mouse model of Alzheimer’s disease. TASTPM transgenic mice and wild-type controls were scanned longitudinally with [18F]-AV45 and [18F]-FDG before (3 months of age) and at multiple time points after the onset of amyloid deposition (6, 9, 12, and 15 months of age). As expected with increasing amyloidosis, TASTPM mice demonstrated progressive age-dependent increases in [18F]-AV45 uptake that were significantly higher than for WT from 9 months onwards and correlated to ex vivo measures of amyloid burden. The metabolism of [18F]-AV45 produces several brain penetrant radiometabolites and normalization to a reference region helps to negate this non-specific binding and improve the sensitivity of [18F]-AV45. The observed trajectory of [18F]-FDG alterations deviated from our proposed hypothesis of gradual decreases with worsening amyloidosis. While [18F]-FDG uptake in TASTPM mice was significantly lower than that of WT at 9 months, reduced [18F]-FDG was not associated with aging in TASTPM mice. Moreover, [18F]-FDG uptake did not correlate to measures of ex vivo amyloid burden. Our findings suggest that while amyloid-β is sufficient to induce hypometabolism, these pathologies are not linked in a dose-dependent manner in TASTPM mice.
Novel Proposal of Lamellar Clustering Process for Elucidation of Tensile Yield Behavior of Linear Polyethylenes

We propose a new solidification process in crystallizable polymers in which lamellar clustering takes place in the crystallization process under high supercoolings. Clustering of lamellae is a two-step process: the first step is the exclusion process of chain ends from the space of a single Gaussian chain accompanied by the cooperative alignment of stiffened segments. This leads to anisotropic cylindrical units including several intertwined chains and is followed by the two-dimensional development of the partially solidified units into the final lamellar cluster. Using a series of polyethylenes with different molecular weights we show that the use of the lamellar cluster model makes it possible to provide a consistent understanding of both the solidification process and tensile yielding behavior in semicrystalline solids. The present model well explains the intercrystalline links found by Keith et al. (J. Polym. Sci. A2 1966, 4, 267–282) and the results which show that the calculation of the strength of the links agree with that of ultra-high-modulus fibers.
The Privacy Implications of Cyber Security Systems

Cyber-security systems, which protect networks and computers against cyber attacks, are becoming common due to increasing threats and government regulation. At the same time, the enormous amount of data gathered by cyber-security systems poses a serious threat to the privacy of the people protected by those systems. To ground this threat, we survey common and novel cyber-security technologies and analyze them according to the potential for privacy invasion. We suggest a taxonomy for privacy risks assessment of information security technologies, based on the level of data exposure, the level of identification of individual users, the data sensitivity and the user control over the monitoring, and collection and analysis of the data. We discuss our results in light of the recent technological trends and suggest several new directions for making these mechanisms more privacy-aware.
Influence of echocardiographic measurements and renal impairments on the prognosis of fulminant myocarditis

Abstract Fulminant myocarditis is a severe cardiac emergency that may lead to death if effective cardiopulmonary supports are not provided. This study aimed to evaluate the prognostic predictors in patients with fulminant myocarditis. We retrospectively analyzed the clinical characteristics, complications, laboratory findings, treatments, as well as electrocardiographic and echocardiographic data of 73 consecutive subjects diagnosed with fulminant myocarditis from June 2012 to June 2016. Logistic regression analysis was used to identify the independent predictive factors of nonsurvivor fulminant myocarditis. Ten patients and 63 patients were assigned to the nonsurvivor and survivor fulminant myocarditis groups, respectively. Patients in the nonsurvivor fulminant myocarditis group had higher heart rates; were more likely to develop clinical complications and supraventricular tachycardia (SVT); and had higher serum creatinine (Scr) level, and had higher white blood cell (WBC) counts, and lower abbreviated estimated glomerular filtration rates (eGFR) than the patients in the survivor fulminant myocarditis group. Moreover, we observed larger left atrium dimension (LAd), larger left ventricular end systolic dimensions, and lower left ventricular ejection fraction in the patients from the nonsurvivor fulminant myocarditis group than in those from the other group. A logistic regression model was constructed and demonstrated that eGFR and LAd were 2 independent predictors of mortality in patients with fulminant myocarditis. Higher heart rates, higher incidences of clinical complication, SVT, higher admission levels of Scr and eGFR, higher WBC counts, higher Scr and eGFR at stage of most severe renal damage, and abnormal echocardiographic findings were associated with high risk of mortality in patients with fulminant myocarditis. The major finding was that eGFR and LAd were independent predictors for in-hospital mortality in patients with fulminant myocarditis.
Early weight loss predicts the reduction of obesity in men with erectile dysfunction and hypogonadism undergoing long-term testosterone replacement therapy

Abstract We and others have previously shown that testosterone replacement therapy (TRT) results in sustained weight loss in the majority of middle-aged hypogonadal men. Previously, however, a small proportion failed to lose at least 5% of their baseline weight. The reason for this is not yet understood. In the present study, we sought to identify early indicators that may predict successful long-term weight loss, defined as a reduction of at least 5% of total body weight relative to baseline weight (T0), in men with hypogonadism undergoing TRT. Eight parameters measured were assessed as potential predictors of sustained weight loss: loss of 3% or more of baseline weight after 1 year of TU treatment, severe hypogonadism, BMI, waist circumference, International Prostate Symptom Score (IPSS), glycated hemoglobin (HbA1C), age and use of vardenafil. Among the eight measured parameters, three factors were significantly associated with sustained weight loss over the entire period of TU treatment: (1) a loss of 3% of the baseline body weight after 1 year of TRT; (2) baseline BMI over 30; and (3) a waist circumference >102 cm. Age was not a predictor of weight loss.
Micropackaging using thin films as mechanical components

The development and testing of simulation software based on variational principles to examine the behavior of structures undergoing large scale elastic deflections is described. The programmes are used in the design of micro mechanical beams for packaging applications, specifically in the domain of passive alignment of optical components. The micromachining/etching fabrication process is described for 5 /spl mu/m thick silicon carbide beams which are then tested by bending them.
Thermal and noise level characteristics of hard dental tissue ablation with 350-fs pulse laser

In spite of intensive research, lasers have not replaced conventional tools in many hard tissue applications. Low removal rates, loud operation noise, and mechanical and thermal damage are among the main obstacles to successful application of lasers. Ultrashort pulse lasers offer several advantages in their high per-pulse-efficiency, negligible thermal and mechanical damage and low noise operation. Practical applications of these devices, however, depends critically on sufficiently high volume removal which should match or even exceed the high speed drill. In our study, acoustical output of the USPL is compared to the low and high speed dental drill, Er:YAG, and Ho:YSGG lasers. Noise levels of the USPL are shown to be negligible in comparison with all other tested system. In addition, thermal characteristics of hard dental tissue ablation by ultrashort pulse laser of low and high pulse repetition rates are presented. Encouraging results showing temperatures increases smaller than 10 degree(s)C even at the highest pulse repetition rates (1 KHz) are presented. A simple model for heat diffusion is discussed.
New insights into diet breadth of polyphagous and oligophagous aphids on two Arabidopsis ecotypes

We investigated whether plant ecotype might affect aphid performance and behavior. The probing behaviors of the polyphagous aphid Myzus persicae and the oligophagous aphid Brevicoryne brassicae on two ecotypes of Arabidopsis thaliana, WS and Col‐0 were recorded using the direct current electrical penetration graph method (DC‐EPG). Myzus persicae displayed a significant preference for the WS ecotype but was not greatly disturbed on Col‐0, while B. brassicae discriminated between the two A. thaliana ecotypes, feeding less on WS than on Col‐0. A Principal Component Analysis of aphid probing behavior data recorded on Col‐0 and WS ecotypes showed that the one of M. persicae was positively correlated with the phloem ingestion phases while the one of B. brassicae was more related to nonfeeding phase. The survival of the aphid species was followed during early larval stages on the two ecotypes and a significantly higher mortality was observed of B. brassicae neonates compared to M. persicae, both reared on WS. Moreover, transcriptomic analysis of noninfested plant leaves from both ecotypes was monitored and underlined constitutive differences between Col‐0 and WS gene expression that might explain the different aphid behaviors. Among a unigene set comprising 39 042 sequences for A. thaliana, 6% were differently expressed affecting, for example, the secondary metabolites and cell wall pathways: two third upregulated in WS and one third upregulated in Col‐0. Thus, the “ecotype” variable should be taken into account when setting up a plant–insect experimental research.
Patient Reported Differences in Dry Eye Disease between Men and Women: Impact, Management, and Patient Satisfaction

Purpose Dry eye disease affects women twice as often as men, but there is little information on whether dry eye treatments, treatment satisfaction, or the impact of dry eye disease on patients’ lives and vision might differ by sex. Design Questionnaire survey of 4000 participants in the Women’s Health Study and the Physicians’ Health Studies I and II with a prior report of a diagnosis of DED. Methods Among participants who re-confirmed a diagnosis of dry eye disease, we assessed symptoms, treatments, patient satisfaction and impact of dry eye disease, and analyzed differences between men and women using regression models. Results The final study population consisted of 1,518 women (mean age 70.7 years) and 581 men (mean age 76.7 years), with a mean reported duration of dry eye disease of 10.5 years and 10.1 years, respectively. The frequency and severity of dry eye disease symptoms were higher among women (each P<0.0001), and women reported a greater impact on everyday activities (P<0.0001). Women were more likely to use artificial tears (P<0.0001) use them more often (P<0.0001), and to use Restasis® (P<0.0001), omega-3 fatty acids (P=0.0006), and have punctal occlusion (P=0.005). Women spent more money per month on dry eye treatments (P<0.0001), but reported greater dissatisfaction with treatment side effects (P=0.001), and the amount of time before treatments started working (P=0.03). Conclusions These data show that dry eye disease is generally experienced as being more severe among women, having a greater impact on their self-assessed well-being.
Cournot Fire Sales

In standard Walrasian macro-finance models, pecuniary externalities due to fire sales lead to excessive borrowing and insufficient liquidity holdings. We investigate whether imperfect competition (Cournot) improves welfare through internalizing the externality and find that this is far from guaranteed. Cournot competition can overcorrect the inefficiently high borrowing in a standard model of levered real investment. By contrast, Cournot competition can exacerbate the inefficiently low liquidity in a standard model of financial portfolio choice. Implications for welfare and regulation are therefore sector specific, depending both on the nature of the shocks and the competitiveness of the industry. (JEL D43, D62, E44, G11, G21, G28, G30)
Secure Cloud Storage Meets with Secure Network Coding

This paper reveals an intrinsic relationship between secure cloud storage and secure network coding for the first time. Secure cloud storage was proposed only recently while secure network coding has been studied for more than ten years. Although the two areas are quite different in their nature and are studied independently, we show how to construct a secure cloud storage protocol given any secure network coding protocol. This gives rise to a systematic way to construct secure cloud storage protocols. Our construction is secure under a definition which captures the real world usage of the cloud storage. Furthermore, we propose two specific secure cloud storage protocols based on two recent secure network coding protocols. In particular, we obtain the first publicly verifiable secure cloud storage protocol in the standard model. We also enhance the proposed generic construction to support user anonymity and third-party public auditing, which both have received considerable attention recently. Finally, we prototype the newly proposed protocol and evaluate its performance. Experimental results validate the effectiveness of the protocol.
HPV self-sampling in Japanese women: A feasibility study in a population with limited experience of tampon use

Objectives Cervical cancer incidence and mortality is increasing in Japanese women under age 50. Screening uptake is low and proactive recommendations for human papillomavirus vaccination have been suspended. Other cervical cancer prevention initiatives are urgently needed. We assessed whether human papillomavirus self-sampling might be an acceptable alternative to physician-led screening, particularly in women with limited experience of tampon use. We also sought to identify any practical, logistical, or safety issues in women already attending for screening, before carrying out further large-scale studies in non-responders. Methods In total, 203 women aged 20–49 attending their annual workplace healthcheck in Sapporo, northern Japan, performed unsupervised human papillomavirus self-sampling before undergoing a physician-led cervical smear and human papillomavirus test, and completing a measure of acceptability for both tests. Results Ninety per cent of participants stated they would use self-sampling again. They found instructions easy to follow and reported no issues with the usability of the self-sampling device. Compared with physician-led testing, women found self-sampling significantly less painful, less embarrassing and could relax more (p < 0.001), regardless of history of tampon use, which was associated with negative experiences in physician sampling (p = 0.034). Women lacked confidence the test had been performed correctly, despite no unsatisfactory samples. No safety issues were reported. Conclusions Self-sampling was highly acceptable in this population of women. They could perform the test safely unsupervised, but lacked confidence the test has been carried out correctly. Japanese women need to be educated about the accuracy of human papillomavirus self-sampling and further large-scale studies are necessary in non-responders.
Specific Lineage‐Priming of Bone Marrow Mesenchymal Stem Cells Provides the Molecular Framework for Their Plasticity

Lineage‐priming is a molecular model of stem cell (SC) differentiation in which proliferating SCs express a subset of genes associated to the differentiation pathways to which they can commit. This concept has been developed for hematopoietic SCs, but has been poorly studied for other SC populations. Because the differentiation potential of human bone marrow mesenchymal stem cells (BM MSCs) remains controversial, we have explored the theory of lineage‐priming applied to these cells. We show that proliferating primary layers and clones of BM MSCs have precise priming to the osteoblastic (O), chondrocytic (C), adipocytic (A), and the vascular smooth muscle (V) lineages, but not to skeletal muscle, cardiac muscle, hematopoietic, hepatocytic, or neural lineages. Priming was shown both at the mRNA (300 transcripts were evaluated) and the protein level. In particular, the master transactivator proteins PPARG, RUNX2, and SOX9 were coexpressed before differentiation induction in all cells from incipient clones. We further show that MSCs cultured in the presence of inducers differentiate into the lineages for which they are primed. Our data point out to a number of signaling pathways that might be activated in proliferating MSCs and would be responsible for the differentiation and proliferation potential of these cells. Our results extend the notion of lineage‐priming and provide the molecular framework for inter‐A, ‐O, ‐C, ‐V plasticity of BM MSCs. Our data highlight the use of BM MSCs for the cell therapy of skeletal or vascular disorders, but provide a word of caution about their use in other clinical indications. Stem Cells 2009;27:1142–1151
Dyadic Neural Similarity During Stress in Mother–Child Dyads

Shared psychological processes between individuals occur most between a mother and her child because the mother-child bond is one of the closest forms of human attachment, in which a mother and her child are essentially wired to connect. We recruited mother-child pairs (Ndyad = 19; adolescent: Mage = 13.74, 11 males; mothers: Mage = 44.26), who each completed an fMRI scan. We examined dyadic neural representational similarity as adolescents completed a stress task and mothers observed their child's performance during the same task. On average, mothers and their children did not show similar neural patterns during stress. However, neural similarity varied depending on family connectedness, such that only dyads reporting high family connectedness showed similar neural profiles. Importantly, increased neural similarity was associated with reduced stress in youth, suggesting that shared neural profiles in mother-child dyads enhance adolescents' psychological well-being.
Refining Word Embeddings Using Intensity Scores for Sentiment Analysis

Word embeddings that provide continuous low-dimensional vector representations of words have been extensively used for various natural language processing tasks. However, existing context-based word embeddings such as Word2vec and GloVe typically fail to capture sufficient sentiment information, which may result in words with similar vector representations having an opposite sentiment polarity (e.g., good and bad), thus degrading sentiment analysis performance. To tackle this problem, recent studies have suggested learning sentiment embeddings to incorporate the sentiment polarity (positive and negative) information from labeled corpora. This study adopts another strategy to learn sentiment embeddings. Instead of creating a new word embedding from labeled corpora, we propose a word vector refinement model to refine existing pretrained word vectors using real-valued sentiment intensity scores provided by sentiment lexicons. The idea of the refinement model is to improve each word vector such that it can be closer in the lexicon to both semantically and sentimentally similar words (i.e., those with similar intensity scores) and further away from sentimentally dissimilar words (i.e., those with dissimilar intensity scores). An obvious advantage of the proposed method is that it can be applied to any pretrained word embeddings. In addition, the intensity scores can provide more fine-grained (real-valued) sentiment information than binary polarity labels to guide the refinement process. Experimental results show that the proposed refinement model can improve both conventional word embeddings and previously proposed sentiment embeddings for binary, ternary, and fine-grained sentiment classification on the SemEval and Stanford Sentiment Treebank datasets.