Miracle-dz/UniFAR-FTUs huggingface dataset:
Auditory temporal integration and the power function model.

The auditory temporal integration function was studied with the objective of improving both its quantitative description and the specification of its principle independent variable, stimulus duration. In Sec. I, temporal integration data from 20 studies were subjected to uniform analyses using standardized definitions of duration and two models of temporal integration. Analyses revealed that these data were best described by a power function model used in conjunction with a definition of duration, termed assigned duration, that de-emphasized the rise/fall portions of the stimuli. There was a strong effect of stimulus frequency and, in general, the slope of the temporal integration function was less than 10 dB per decade of duration; i.e., a power function exponent less than 1.0. In Sec. II, an experimental study was performed to further evaluate the models and definitions. Detection thresholds were measured in 11 normal-hearing human subjects using a total of 24 single-burst and multiple-burst acoustic stimuli of 3.125 kHz. The issues addressed are: the quantitative description of the temporal integration function; the definition of stimulus duration; the similarity of the integration processes for single-burst and multiple-burst stimuli; and the contribution of rise/fall time to the integration process. A power function in conjunction with the assigned duration definition was again most effective in describing the data. Single- and multiple-burst stimuli both seemed to be integrated by the same central mechanism, with data for each type of stimulus being described by a power function exponent of approximately 0.6 at 3.125 kHz. It was concluded that the contribution of the rise/fall portions of the stimuli can be factored out from the rest of the temporal integration process. In Sec. III, the conclusions that emerged from the review of published work and the present experimental work suggested that auditory temporal integration is best described by a power function in conjunction with the assigned duration definition. The exponent for the power function is typically less than 1.0, and varies with frequency and hearing level. Second, a means of empirically assaying the contribution of the rise-fall portions of the stimuli is presented and evaluated. Finally, properties of a central auditory integrator are hypothesized. (ABSTRACT TRUNCATED AT 250 WORDS)
t / after verb stems in Ajyíninka Apurucayali

This paper proposes a new deletion analysis of [t]-zero alternations in Ajyíninka Apurucayali (often cited as 'Axininca Campa'). It is argued that the analysis assuming /t/-deletion fares better than an insertion analysis in two respects. First, the insertion analysis predicts an unattested stem type for verbs. Second, the insertion analysis fails to capture a generalization about hiatus resolution whereby vowel sequences undergo deletion, shortening, long vowel formation, or diphthong formation in a set of morphologically unrelated environments. The deletion analysis relies on the notion of preservation of the marked (de Lacy, 2006) and utilizes an independently motivated stratal organization of Apurucayali phonology in accounting for restrictions on verbal stems. The proposed analysis has important implications for the typology of epenthesis.
International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease

Background: Nonmotor symptoms (NMS) have a great impact on patients with Parkinson disease (PD). The Non-Motor Symptoms Scale (NMSS) is an instrument specifically designed for the comprehensive assessment of NMS in patients with PD. NMSS psychometric properties have been tested in this study. Methods: Data were collected in 12 centers across 10 countries in America, Asia, and Europe. In addition to the NMSS, the following measures were applied: Scales for Outcomes in Parkinson’s Disease (SCOPA)-Motor, SCOPA-Psychiatric Complications (SCOPA-PC), SCOPA-Cognition, Hoehn and Yahr Staging (HY), Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD), SCOPA-Autonomic, Parkinson’s Disease Sleep Scale (PDSS), Parkinson’s Disease Questionnaire–39 items (PDQ-39), and EuroQol–5 dimensions (EQ-5D). NMSS acceptability, reliability, validity, and precision were analyzed. Results: Four hundred eleven patients with PD, 61.3% men, were recruited. The mean age was 64.5 ± 9.9 years, and mean disease duration was 8.1 ± 5.7 years. The NMSS score was 57.1 ± 44.0 points. The scale was free of floor or ceiling effects. For domains, the Cronbach α coefficient ranged from 0.44 to 0.85. The intraclass correlation coefficient (0.90 for the total score, 0.67–0.91 for domains) and Lin concordance coefficient (0.88) suggested satisfactory reproducibility. The NMSS total score correlated significantly with SCOPA-Autonomic, PDQ-39, and EQ-5D (rS = 0.57–0.70). Association was close between NMSS domains and the corresponding SCOPA–Autonomic domains (rS = 0.51–0.65) and also with scales measuring related constructs (PDSS, SCOPA-PC) (all p < 0.0001). The NMSS total score was higher for women (p < 0.02) and for increasing disease duration, HY, and CISI-PD severity level (p < 0.001). The SEM was 13.91 for total score and 1.71 to 4.73 for domains. Conclusion: The Non-Motor Symptoms Scale is an acceptable, reproducible, valid, and precise assessment instrument for nonmotor symptoms in Parkinson disease.
Acute or chronic stress induce cell compartment-specific phosphorylation of glucocorticoid receptor and alter its transcriptional activity in Wistar rat brain

Chronic stress and impaired glucocorticoid receptor (GR) feedback are important factors for the compromised hypothalamic–pituitary–adrenal (HPA) axis activity. We investigated the effects of chronic 21 day isolation of Wistar rats on the extrinsic negative feedback part of HPA axis: hippocampus (HIPPO) and prefrontal cortex (PFC). In addition to serum corticosterone (CORT), we followed GR subcellular localization, GR phosphorylation at serine 232 and serine 246, expression of GR regulated genes: GR, CRF and brain-derived neurotropic factor (BDNF), and activity of c-Jun N-terminal kinase (JNK) and Cdk5 kinases that phosphorylate GR. These parameters were also determined in animals subjected to acute 30 min immobilization, which was taken as ‘normal’ adaptive response to stress. In isolated animals, we found decreased CORT, whereas in animals exposed to acute immobilization, CORT was markedly increased. Even though the GR was predominantly localized in the nucleus of HIPPO and PFC in acute, but not in chronic stress, the expression of GR, CRF, and BDNF genes was similarly regulated under both acute and chronic stresses. Thus, the transcriptional activity of GR under chronic isolation did not seem to be exclusively dependent on high serum CORT levels nor on the subcellular location of the GR protein. Rather, it resulted from the increased Cdk5 activation and phosphorylation of the nuclear GR at serine 232 and the decreased JNK activity reflected in decreased phosphorylation of the nuclear GR at serine 246. Our study suggests that this nuclear isoform of hippocampal and cortical GR may be related to hypocorticism i.e. HPA axis hypoactivity under chronic isolation stress.
Emotional and behavioral symptoms in children with acute leukemia.

BACKGROUND AND OBJECTIVES The diagnosis of leukemia is probably one of the most severe stressors that children can experience and may be associated with emotional and behavioral symptoms indicating comorbidity with mental health disorders. This study aims to evaluate the presence of emotional and behavioral symptoms in children with acute leukemia exposed to chemotherapy from outpatient services at two university hospitals in Brazil. DESIGN AND METHODS In this cross-sectional study, emotional and behavioral symptoms were assessed using the Children Behavior Checklist (CBCL) in three groups of children aged 5-14 years: a) children with acute leukemia (n = 21); b) children with blood dyscrasias (n = 21); c) children evaluated or treated in a pediatric outpatient service (n = 33). RESULTS Children with blood dyscrasias had significantly few symptoms of externalization (delinquent and aggressive behavior) than pediatric controls (p< 0.05). Children with leukemia did not differ from the two other groups regarding symptoms of externalization. No significant difference on the scores of the CBCL internalization dimension (anxiety, depression, somatic symptoms and withdrawn) was found among the three groups. INTERPRETATION AND CONCLUSIONS These findings seem to indicate that children with acute leukemia do not have more emotional or behavioral symptoms than children with benign hematologic or physical diseases suggesting that comorbidity with mental disorders is not higher in children with acute leukemia than in children in the other two groups.
Neuroacanthocytosis in China: A Review of Published Reports

Background Neuroacanthocytosis (NA) syndromes are a group of rare diseases characterized by the presence of acanthocytes and neuronal multisystem pathology, including chorea-acanthocytosis (ChAc), McLeod syndrome (MLS), Huntington's disease-like 2 (HDL-2), and pantothenate kinase-associated neurodegeneration (PKAN). China has the largest population in the world, which makes it a good location for investigating rare diseases like NA. Methods We searched Medline, ISI Proceedings, China National Knowledge Infrastructure, and Wanfang Data for literature published through December 31, 2013 for all the published Chinese NA case reports and extracted the clinical and laboratory findings. Results A total of 42 studies describing 66 cases were found to be eligible for inclusion. Age of symptom onset ranged from 5 to 74 years. The most common findings included hyperkinetic movements (88%), orofacial dyskinesia (80%), dystonia (67%), and dysarthria (68%), as well as caudate atrophy or enlarged lateral ventricles on neuroimaging (64%), and elevated creatine kinase (52%). Most cases were not confirmed by any specific molecular tests. Only two cases were genetically studied and diagnosed as ChAc or MLS. Discussion In view of the prevalence of NA syndromes in other countries, the number of patients in China appears to be underestimated. Chinese NA patients may benefit from the establishment of networks that offer specific diagnoses and care for rare diseases.
Spectal variation of vegetative areas in leaf-off season observed by hyperspectral data

Due to the phenological variation of vegetation growth in temperate region, it is often difficult to accurately assess the surface conditions on agricultural croplands, grasslands, and disturbed forests by current multi-spectral remote sensor data. In particular, the spectral similarity between soil and dry vegetation has been primary concern to correctly appraise the surface conditions during the non-growing seasons in temperature region. This study analyzes the spectral characteristics of the mixture of dry vegetation and soil. The reflectance spectra were obtained from laboratory spectroradiometer measurement and from EO-1 Hyperion image data. The reflectance spectra of several samples having different level of dry vegetation fractions show similar pattern from both lab measurement and hyperspectral image. Shortwave IR wavelengths, in particular at wavelength near 2200nm, are more sensitive to the fraction of dry vegetation. The reflectance spectra of bare soil could be distinguished from the other surfaces covered by dry vegetation during the leaf-off season. © 2005 IEEE.
Application of Yoga in Residential Treatment of Traumatized Youth

Background: The Trauma Center at Justice Resource Institute has adapted a form of Hatha yoga into a trauma-sensitive adjunctive component of intervention for use with complexly traumatized individuals exhibiting chronic affective and somatic dysregulation and associated behavioral, functioning, and health complaints. Objectives: This article explores the use of yoga with traumatized youth (aged 12-21 years) in residential treatment. Design: A review of the literature on the somatic impact of trauma exposure provides a rationale for the use of yoga with this population and highlights an emerging evidence base in support of this practice. Case vignettes illustrate the integration of structured, gentle yoga practices into residential programming for youth with severe emotional and behavioral problems. Results: Anecdotal data and clinical observation underscore the promise of yoga as a viable approach to build self-regulatory capacity of traumatized youth. Conclusions: Future directions in the development and evaluation of trauma-informed yoga practices for youth are discussed.
Design and analysis of eccentrically braced steel frames with vertical links using shape memory alloys

In recent years, the philosophy behind traditional methods by which structures were designed to withstand natural disasters has gone through major changes. Shape memory alloys (SMAs) are characterized by their superelastic behavior, which enables them to recover their original shape after experiencing large deformations. This characteristic provides an ideal reversibility capacity that can be used in the passive control of buildings exposed to earthquakes. This article has attempted to identify the effects of changing the hysteretic characteristics of SMA materials when they are used as passive control systems in eccentric bracing frames. By evaluating the numerical analysis results obtained from the modeling of an experimental sample and the modeling of the proposed EBF system, the accuracy of the above-stated notion was confirmed. Moreover, the results that pertain to the nonlinear pushover analysis, time-history dynamic analysis and seismic damage analysis of eccentric steel bracing frames of 4-, 9- and 14-story structures indicate that the use of SMA superelastic materials, in addition to effectively improving their ductility, stiffness and lateral strength, provides an excellent reversibility capacity, which considerably reduces both the maximum relative displacement and the residual deformation in the structure.
One Too Many? Understanding the Influence of Risk Factor Quantity on Perceptions of Risk

Forming a subjective risk judgment in circumstances that feature multiple risk factors is a common, yet complex task. One would expect variations in the number of risk factors in a given situation to have an important influence on risk judgments, yet the exact nature of this influence remains empirically untested. We conducted three studies to address this issue. In Study 1, we found that, when individuals were confronted with a preset number of risk factors (zero, one, two, or three) in the same scenario, their risk judgments were virtually identical for zero, one, and two risk factors, yet markedly higher for three risk factors. By contrast, Study 2 showed that when confronted with variations in the number of risk factors (zero, one, two, and three) for that same scenario, individuals' risk judgments increased/decreased in relatively even increments concurrent with increases/decreases in the number of risk factors. Study 3 identified that pronounced increases in risk judgments, like those observed in Study 1, may occur when the numbers of factors is “high” relative to the potential victim's vulnerability to those factors. Our results show that the number of risk factors in given circumstances can have an important influence on risk judgments and that this influence can differ based on the characteristics of the situation. We discuss how these findings provide a better understanding of subjective risk judgments and highlight the importance of those who seek to communicate risk information being mindful of how data about multiple risk factors could be (mis)interpreted.
Parallel routing algorithms for nonblocking electronic and photonic switching networks

We study the connection capacity of a class of rearrangeable nonblocking (RNB) and strictly nonblocking (SNB) networks with/without crosstalk-free constraint, model their routing problems as weak or strong edge-colorings of bipartite graphs, and propose efficient routing algorithms for these networks using parallel processing techniques. This class of networks includes networks constructed from banyan networks by horizontal concatenation of extra stages and/or vertical stacking of multiple planes. We present a parallel algorithm that runs in O(lg/sup 2/ N) time for the RNB networks of complexities ranging from O(N lg N) to O(N/sup 1.5/ lg N) crosspoints and parallel algorithms that run in O(min{d* lg N, /spl radic/N}) time for the SNB networks of O(N/sup 1.5/ lg N) crosspoints, using a completely connected multiprocessor system of N processing elements. Our algorithms can be translated into algorithms with an O(lg N lg lg N) slowdown factor for the class of N-processor hypercubic networks, whose structures are no more complex than a single plane in the RNB and SNB networks considered.
Investigation of the halo-artifact in 68Ga-PSMA-11-PET/MRI

Objectives Combined positron emission tomography (PET) and magnetic resonance imaging (MRI) targeting the prostate-specific membrane antigen (PSMA) with a 68Ga-labelled PSMA-analog (68Ga-PSMA-11) is discussed as a promising diagnostic method for patients with suspicion or history of prostate cancer. One potential drawback of this method are severe photopenic (halo-) artifacts surrounding the bladder and the kidneys in the scatter-corrected PET images, which have been reported to occur frequently in clinical practice. The goal of this work was to investigate the occurrence and impact of these artifacts and, secondly, to evaluate variants of the standard scatter correction method with regard to halo-artifact suppression. Methods Experiments using a dedicated pelvis phantom were conducted to investigate whether the halo-artifact is modality-, tracer-, and/or concentration-dependent. Furthermore, 31 patients with history of prostate cancer were selected from an ongoing 68Ga-PSMA-11-PET/MRI study. For each patient, PET raw data were reconstructed employing six different variants of PET scatter correction: absolute scatter scaling, relative scatter scaling, and relative scatter scaling combined with prompt gamma correction, each of which was combined with a maximum scatter fraction (MaxSF) of MaxSF = 75% or MaxSF = 40%. Evaluation of the reconstructed images with regard to halo-artifact suppression was performed both quantitatively using statistical analysis and qualitatively by two independent readers. Results The phantom experiments did not reveal any modality-dependency (PET/MRI vs. PET/CT) or tracer-dependency (68Ga vs. 18F-FDG). Patient- and phantom-based data indicated that halo-artifacts derive from high organ-to-background activity ratios (OBR) between bladder/kidneys and surrounding soft tissue, with a positive correlation between OBR and halo size. Comparing different variants of scatter correction, reducing the maximum scatter fraction from the default value MaxSF = 75% to MaxSF = 40% was found to efficiently suppress halo-artifacts in both phantom and patient data. In 1 of 31 patients, reducing the maximum scatter fraction provided new PET-based information changing the patient’s diagnosis. Conclusion Halo-artifacts are particularly observed for 68Ga-PSMA-11-PET/MRI due to 1) the biodistribution of the PSMA-11-tracer resulting in large OBRs for bladder and kidneys and 2) inaccurate scatter correction methods currently used in clinical routine, which tend to overestimate the scatter contribution. If not compensated for, 68Ga-PSMA-11 uptake pathologies may be masked by halo-artifacts leading to false-negative diagnoses. Reducing the maximum scatter fraction was found to efficiently suppress halo-artifacts.
A β1 integrin signaling pathway involving Src‐family kinases, Cbl and PI‐3 kinase is required for macrophage spreading and migration

We have used mutant macrophages which are deficient in expression of Src‐family kinases to define an integrin signaling pathway that is required for macrophage adhesion and migration. Following ligation of surface integrins by fibronectin, the p120c‐cbl (Cbl) protein rapidly becomes tyrosine phosphorylated and associated with the Src‐family kinases Fgr and Lyn. In hck−/−fgr−/−lyn−/− triple mutant cells, which are defective in spreading on fibronectin‐coated surfaces in vitro and show impaired migration in vivo, Cbl tyrosine phosphorylation is blocked, Cbl protein levels are low, adhesion‐dependent translocation of Cbl to the membrane is impaired and Cbl‐associated, membrane‐localized phosphatidylinositol 3 (PI‐3)‐kinase activity is dramatically reduced. In contrast, adhesiondependent activation of total cellular PI‐3 kinase activity is normal in mutant cells, demonstrating that it is the membrane‐associated fraction of PI‐3 kinase which is most critical in regulating actin cytoskeletal rearrangements that lead to cell spreading. Treatment of wild‐type cells with the Src‐family‐specific inhibitor PP1, Cbl antisense oligonucleotides or pharmacological inhibitors of PI‐3 kinase blocks cell spreading on fibronectin surfaces. These data provide a molecular description for the role of Src‐family kinases Hck, Fgr and Lyn in β1‐integrin signal transduction in macrophages.
Macrophage-Mediated Inflammation and Disease: A Focus on the Lung

The lung is exposed to a vast array of inhaled antigens, particulate matter, and pollution. Cells present in the airways must therefore be maintained in a generally suppressive phenotype so that excessive responses to nonserious irritants do not occur; these result in bystander damage to lung architecture, influx of immune cells to the airways, and consequent impairment of gas exchange. To this end, the resident cells of the lung, which are predominantly macrophages, are kept in a dampened state. However, on occasion the suppression fails and these macrophages overreact to antigenic challenge, resulting in release of inflammatory mediators, induction of death of lung epithelial cells, deposition of extracellular matrix, and development of immunopathology. In this paper, we discuss the mechanisms behind this macrophage-mediated pathology, in the context of a number of inflammatory pulmonary disorders.
CORRECTION BETWEEN THE GROSS MOTOR FUNCTION MEASURE SCORES AND GAIT SPATIOTEMPORAL MEASURES IN CHILDREN WITH NEUROLOGICAL IMPAIRMENTS

Twenty six children with a diagnosis of cerebral palsy and four with a diagnosis of head injury, aged between 1 and 8 years, participated in this study, undertaken to determine the relation between spatiotemporal measures (STM) of gait (velocity, cadence, stride length, and cycle duration) and the results of a standardized clinical test of motor function. STM were assessed by a clinical videographic gait test (VGT) whereas the Gross Motor Function Measure (GMFM) was used to assess motor function. For the total group of children, significant linear relations (r=0.91, r= 0.93: p < 0.0001) were obtained between gait velocity and the GMFM sections D and E which include gait‐related activities. These indicate that velocity is a parameter capable of reflecting functional locomotor behavior of these children. The results suggest that GMFM sections D and E may be used as locomotor predictors. The effect of walking with or without support was also investigated. The correlation between gait velocity and the GMFM(E) score was higher (r=0.69) in the group of children walking with support than in those walking without (r=0.35). The first group were younger and walked at velocities under 45 cm/s whereas children walking without support were older and walked at velocities ranging from 55 to 110 cm/s. These results suggest that the GMFM(E) score becomes less discriminant at gait velocities above 45 cm/s.