Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic effect of dexamethasone implant in retinal vein occlusions resistant to anti-VEGF therapy

Purpose To test the efficacy of the intravitreal dexamethasone (DEX) implant in patients with retinal vein occlusions (RVOs) who have failed multiple anti-vascular endothelial growth factor (anti-VEGF) treatments. Methods A randomized exploratory study of ten patients with branch RVO or central RVO who received at least two previous anti-VEGF treatments and had persistent or unresponsive cystoid macular edema. Treatment with the DEX implant was either every 4 months or pro re nata (PRN) depending on their group assignment for 1 year. Multifocal electroretinography and microperimetry were the primary end points, with high-resolution optical coherence tomography and best-corrected visual acuity as the secondary end points. Results All patients in both the every 4 month and PRN cohorts who completed the study received the three maximal injections of DEX; therefore, the data from both cohorts were combined and reported as a case series. On average, the multifocal electroretinography amplitude increased significantly from 5.11±0.66 to 24.19±5.30 nV/deg2 at 12 months (P<0.005), mean macular sensitivity increased from 7.67±2.10 to 8.01±1.98 dB at 4 months (P=0.32), best-corrected visual acuity increased significantly from 51.0±5.1 to 55.4±5.1 early treatment of diabetic retinopathy study letters at 2 months (P<0.05), and central retinal thickness decreased from 427.6±39.5 to 367.1±37.8 μm at 4 months (P<0.05). Intraocular pressure increased significantly in one patient, with that patient requiring an additional glaucoma medication for management. Additionally, cataract progression increased significantly (P<0.05) in this patient population and partially limited analysis of other end points. Conclusion DEX should be considered as a treatment option in patients with RVOs who have failed anti-VEGF therapy, as the results of this study demonstrated an improvement in retinal morphology and macular function. Cataract progression did occur following multiple consecutive injections; however, steroid-induced glaucoma was not a limiting factor.
Bacterial Epimerization as a Route for Deoxynivalenol Detoxification: the Influence of Growth and Environmental Conditions

Deoxynivalenol (DON) is a toxic secondary metabolite produced by several Fusarium species that infest wheat and corn. Food and feed contaminated with DON pose a health risk to both humans and livestock and form a major barrier for international trade. Microbial detoxification represents an alternative approach to the physical and chemical detoxification methods of DON-contaminated grains. The present study details the characterization of a novel bacterium, Devosia mutans 17-2-E-8, that is capable of transforming DON to a non-toxic stereoisomer, 3-epi-deoxynivalenol under aerobic conditions, mild temperature (25–30°C), and neutral pH. The biotransformation takes place in the presence of rich sources of organic nitrogen and carbon without the need of DON to be the sole carbon source. The process is enzymatic in nature and endures a high detoxification capacity (3 μg DON/h/108 cells). The above conditions collectively suggest the possibility of utilizing the isolated bacterium as a feed treatment to address DON contamination under empirical field conditions.
Image restoration by sparse 3D transform-domain collaborative filtering

We propose an image restoration technique exploiting regularized inversion and the recent block-matching and 3D filtering (BM3D) denoising filter. The BM3D employs a non-local modeling of images by collecting similar image patches in 3D arrays. The so-called collaborative filtering applied on such a 3D array is realized by transformdomain shrinkage. In this work, we propose an extension of the BM3D filter for colored noise, which we use in a two-step deblurring algorithm to improve the regularization after inversion in discrete Fourier domain. The first step of the algorithm is a regularized inversion using BM3D with collaborative hard-thresholding and the seconds step is a regularized Wiener inversion using BM3D with collaborative Wiener filtering. The experimental results show that the proposed technique is competitive with and in most cases outperforms the current best image restoration methods in terms of improvement in signal-to-noise ratio.
Tooth Loss and Lack of Regular Oral Hygiene Are Associated with Higher Risk of Esophageal Squamous Cell Carcinoma

We tested the association between tooth loss and oral hygiene and the risk of esophageal squamous cell carcinoma (ESCC) in people living in a high-risk area of Iran. We used a case-control study of pathologically confirmed ESCC cases (n = 283) and controls (n = 560) matched on sex, age, and neighborhood. Subjects with ESCC had significantly more decayed, missing, or filled teeth (DMFT) with a median (interquartile range) of 31 (23-32) compared with controls 28 (16-32; P = 0.0045). Subjects with ESCC were significantly more likely than controls to fail to practice regular oral hygiene (78% versus 58%). In multivariate-adjusted conditional logistic regression models, having 32 DMFT compared with ≤15 conferred an odds ratio (95% confidence interval) of 2.10 (1.19-3.70). Compared with daily tooth brushing, practicing no regular oral hygiene conferred an odds ratio (95% confidence interval) of 2.37 (1.42-3.97). Restricting the analysis to subjects that had never smoked tobacco did not materially alter these results. We found significant associations between two markers of poor oral hygiene, a larger number of DMFT and lack of daily tooth brushing, and risk of ESCC in a population at high risk for ESCC where many cases occur in never smokers. Our results are consistent with several previous analyses in other high-risk populations. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3062–8)
Changes in Serum Growth Hormone Levels from Fetal to Adult Age in the Rat 1

Summary The concentration of immunoreactive growth hormone (GH) in the serum of rats increased significantly from the 19th to the 21st day of fetal life, began to decrease on the last day of gestation, reached minimum values on the 20th day of extrauterine life and increased again after the pups were weaned. The relative rate of weight gain was greatest between the 19th and the 20th day of fetal life. After this time, it declined progressively, except for a brief period between the 5th and 10th day after birth. Thus, this parameter of growth followed a course that was more closely parallel to previously published changes in the level of serum insulin than in the changes in serum GH observed in these experiments. It is possible that, in fetal and young rats, growth may depend upon a combined action of insulin and GH in which the latter, rather than the former, plays the role of permissive factor. Addendum. Since this manuscript was submitted for publication, we found that the oral administration of glucose (2 g/kg) or of a 10-amino acids mixture (41) (1 g/kg) had no effect on the serum growth hormone levels of 19-day-old rat fetuses and of 1-hr, 5-, 10-, 20-, 30-, and 45-day-old pups. These results support the notion that, in the rat, the release of growth hormone does not respond to stimuli that are effective in other species (42, 43). We wish to call the reader's attention to a similar study published very recently (44).
Permutation importance: a corrected feature importance measure

MOTIVATION In life sciences, interpretability of machine learning models is as important as their prediction accuracy. Linear models are probably the most frequently used methods for assessing feature relevance, despite their relative inflexibility. However, in the past years effective estimators of feature relevance have been derived for highly complex or non-parametric models such as support vector machines and RandomForest (RF) models. Recently, it has been observed that RF models are biased in such a way that categorical variables with a large number of categories are preferred. RESULTS In this work, we introduce a heuristic for normalizing feature importance measures that can correct the feature importance bias. The method is based on repeated permutations of the outcome vector for estimating the distribution of measured importance for each variable in a non-informative setting. The P-value of the observed importance provides a corrected measure of feature importance. We apply our method to simulated data and demonstrate that (i) non-informative predictors do not receive significant P-values, (ii) informative variables can successfully be recovered among non-informative variables and (iii) P-values computed with permutation importance (PIMP) are very helpful for deciding the significance of variables, and therefore improve model interpretability. Furthermore, PIMP was used to correct RF-based importance measures for two real-world case studies. We propose an improved RF model that uses the significant variables with respect to the PIMP measure and show that its prediction accuracy is superior to that of other existing models. AVAILABILITY R code for the method presented in this article is available at http://www.mpi-inf.mpg. de/ approximately altmann/download/PIMP.R CONTACT: altmann@mpi-inf.mpg. de, laura.tolosi@mpi-inf.mpg. de SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
PG 1553+113: FIVE YEARS OF OBSERVATIONS WITH MAGIC

We present the results of five years (2005–2009) of MAGIC observations of the BL Lac object PG 1553+113 at very high energies (VHEs; E > 100 GeV). Power-law fits of the individual years are compatible with a steady mean photon index Γ = 4.27 ± 0.14. In the last three years of data, the flux level above 150 GeV shows a clear variability (probability of constant flux < 0.001%). The flux variations are modest, lying in the range from 4% to 11% of the Crab Nebula flux. Simultaneous optical data also show only modest variability that seems to be correlated with VHE gamma-ray variability. We also performed a temporal analysis of (all available) simultaneous Fermi/Large Area Telescope data of PG 1553+113 above 1 GeV, which reveals hints of variability in the 2008–2009 sample. Finally, we present a combination of the mean spectrum measured at VHEs with archival data available for other wavelengths. The mean spectral energy distribution can be modeled with a one-zone synchrotron self-Compton model, which gives the main physical parameters governing the VHE emission in the blazar jet.
Optimal Information Transfer in the Cortex through Synchronization

In recent experimental work it has been shown that neuronal interactions are modulated by neuronal synchronization and that this modulation depends on phase shifts in neuronal oscillations. This result suggests that connections in a network can be shaped through synchronization. Here, we test and expand this hypothesis using a model network. We use transfer entropy, an information theoretical measure, to quantify the exchanged information. We show that transferred information depends on the phase relation of the signal, that the amount of exchanged information increases as a function of oscillations in the signal and that the speed of the information transfer increases as a function of synchronization. This implies that synchronization makes information transport more efficient. In summary, our results reinforce the hypothesis that synchronization modulates neuronal interactions and provide further evidence that gamma band synchronization has behavioral relevance.
The effect of omega-3 unsaturated fatty acids on non-alcoholic fatty liver disease: A systematic review and meta-analysis of RCTs

Objective: During the treatment of diseases such as angiocardiopathy, blood lipid abnormalities and metabolic syndrome, omega-3 unsaturated fatty acids (PUFA) can reduce plasma lipids and improve cardiovascular status, thus ameliorating disease severity. We aimed to explore the effects of PUFA supplementation in patients with non-alcoholic fatty liver disease (NAFLD). Methods: A systematic literature search was performed during March 2016 for randomized controlled trials using PUFA or fish oil supplementation in patients with NAFLD or non-alcoholic steatohepatitis (NASH). All Randomized controlled trials were retrieved from MEDLINE and EMBASE database up to date (March 2016). A meta-analysis of key outcomes (serum level of liver enzymes and lipids) were identified in these studies. The mean difference (MD) and the corresponding 95% confidence intervals (CIs) were used as measures of effect size. Results: Thirteen studies were included, consisting of 266 patients in the PUFA group and 402 cases in the control group. Serum level of alanine aminotransferase (ALT) was lower in the PUFA group than that in in the controls [MD=−9.18, 95% CI (−12.41, −5.96), P <0.00001]. However, PUFA treatment did not affect aspartate aminotransferase (AST) [MD=−5.07, 95% CI (−12.65, 2.51), P= 0.19], gamma-glutamyl transferase (GGT) [MD=−1.91, 95% CI (−4.15, 0.33), P <0.009]. Conclusions: PUFA supplementation may affects serum level of ALT and improve liver function in patients with NAFLD.
The effectiveness of multimedia programmes in children's vocabulary learning

The present experiment investigated the effect of three different presentation modes in children's vocabulary learning with a self-guided multimedia programmes. Participants were 135 third and fourth grade children who read a short English language story presented by a computer programme. For 12 key (previously unknown) words in the story, children received verbal annotations (written translation), visual annotations (picture representing the word), or both. Recall of word translations was better for children who only received verbal annotations than for children who received simultaneously visual and verbal annotations or visual annotations only. Results support previous research about cognitive load in e-learning environments, and show that children's learning processes are hindered by limited working memory. This finding implies a challenge for multimedia programmes designed for children and based on self-regulated learning. [ABSTRACT FROM AUTHOR]
Variety Amnesia : Recalling Past Variety Can Accelerate Recovery from Satiation

Consumers frequently consume items to the point where they no longer enjoy them. In a pilot study and two experiments spanning three distinct classes of stimuli, we find that people can recover from this satiation by simply recalling the variety of alternative items they have consumed in the past. And yet, people seem to exhibit “variety amnesia” in that they do not spontaneously recall this past variety despite the fact that it would result in a desirable decrease in satiation. Thus, rather than satiation being a fixed physiological process, it appears that it is at least partially constructed in the moment. We discuss some of the theoretical implications of these findings and provide some prescriptive measures for both marketers and consumers.
Childhood Tuberculosis in a Sub-Saharan Tertiary Facility: Epidemiology and Factors Associated with Treatment Outcome

Childhood tuberculosis (TB) is a diagnostic challenge in developing countries, and patient outcome can be influenced by certain factors. We report the disease course, clinical profile and factors associated with treatment outcome in a tertiary facility of Kinshasa. Documentary and analytical studies were conducted using clinical and exploratory data for children aged up to 15 years who were admitted to the University Clinics of Kinshasa for TB. Data are presented as frequencies and averages, and binary and logistic regression analyses were performed. Of 283 children with TB, 82 (29.0%) had smear-negative TB, 40 (14.1%) had smear-positive TB, 159 (56.1%) had extra-pulmonary TB (EPTB), 2 (0.7%) had multidrug-resistant TB (MDR-TB), 167 (59.0%) completed treatment, 30 (10.6%) were cured, 7 (2.5%) failed treatment, 4 (1.4%) died, 55 (19.4%) were transferred to health centers nearest their home, and 20 (7.0%) were defaulters. In the binary analysis, reported TB contacts (p = 0.048), type of TB (p = 0.000), HIV status (p = 0.050), Ziehl-Nielsen test result (p = 0.000), Lowenstein culture (p = 0.004) and chest X-ray (p = 0.057) were associated with outcome. In the logistic regression, none of these factors was a significant predictor of outcome. Tertiary level care facilities must improve the diagnosis and care of patients with childhood TB, which justifies the development of alternative diagnostic techniques and the assessment of other factors that potentially affect outcome.
Photometric Gaussian mixtures based visual servoing

The advantages of using the entire photometric image information as visual feature are: it does not require any feature detections, matching or tracking process. To enlarge the convergence domain, we propose to accomplish visual servoing based on the analytical formulation of Gaussian mixtures to model the images. During the servoing, we consider the optimization of the Gaussian spreads allowing the camera to converge to a desired pose even from a far initial one. Simulation that overcomes the state-of-the-art and real experiments highlight the success of our approach.
Thrombolysis of occluded infra-inguinal bypass grafts: is it worthwhile ?

Abstract Background: Thrombosis of an infra-inguinal bypass graft often results in a limb-threatening ischemia. There is no consensus on the optimal management strategy. Aim of the study: To analyse safety and efficacy of catheter-guided intra-arterial thrombolysis to re-open thrombosed infra-inguinal bypass grafts and to identify factors that influence graft patency and limb salvage rate after thrombolytic procedures. Methods: A continuous cohort-study of 106 thrombolytic procedures between 1993 to 2008. Results: Despite a high initial success rate (76%), the mid-term results are less convincing, with a 58% re-occlusion rate at 45 months follow-up. Thrombosed vein grafts, old (2 weeks or more) occlusions, poor run-off and failure to identify or rectify an underlying causative stenosis are determinant for a poor long-term outcome of thrombolytic procedures. Comments: The outcome results of author’s experience are consistent with literature reports. Thrombolysis of occluded infra-inguinal bypass grafts should be limited to selective cases (recent occlusion, prosthetic or vein graft in place since 1 year or more, critical limb ischemia). Despite its obvious advantages, the long-term outcome of thrombolytic procedures is deceiving. The inherent risk of hemorrhagic complications should also be taken in account at the decision making of treatment strategy. The question wether, in general, catheter-guided selective intra-arterial thrombolysis offers a significant advantage over operative revascularisation (thrombectomy or new bypass) remains unanswered. A more selective approach seems to favour thrombolysis as most appropriate strategy in the management of recent (< 2 weeks) thromboses of grafts in place since at least 1 year.
Dietary fish oil modulates macrophage fatty acids and decreases arthritis susceptibility in mice

B10.RIII and B10.G mice were transferred from a diet of laboratory rodent chow to a standard diet in which all the fat (5% by weight) was supplied as either fish oil (17% eicosapentaenoic acid [EPA], 12% docosahexaenoic acid [DHA], 0% arachidonic acid [AA], and 2% linoleic acid) or corn oil (0% EPA, 0% DHA, 0% AA, and 65% linoleic acid). The fatty acid composition of the macrophage phospholipids from mice on the chow diet was similar to that of mice on a corn oil diet. Mice fed the fish oil diet for only 1 wk showed substantial increases in macrophage phospholipid levels of the omega-3 fatty acids (of total fatty acid 4% was EPA, 10% docosapentaenoic acid [DPA], and 10% DHA), and decreases in omega-6 fatty acids (12% was AA, 2% docosatetraenoic acid [DTA], and 4% linoleic acid) compared to corn oil-fed mice (0% EPA, 0% DPA, 6% DHA, 20% AA, 9% DTA, and 8% linoleic acid). After 5 wk this difference between the fish oil-fed and corn oil-fed mice was even more pronounced. Further small changes occurred at 5-9 wk. We studied the prostaglandin (PG) and thromboxane (TX) profile of macrophages prepared from mice fed the two diets just before being immunized with collagen. Irrespective of diet, macrophages prepared from female mice and incubated for 24 h had significantly more PG and TX in the medium than similarly prepared macrophages from male mice. The increased percentage of EPA and decreased percentage of AA in the phospholipids of the macrophages prepared from the fish oil-fed mice was reflected in a reduction in the amount of PGE2 and PGI2 in the medium relative to identically incubated macrophages prepared from corn oil-fed mice. When this same fish oil diet was fed to B10.RIII mice for 26 d before immunization with type II collagen, the time of onset of arthritis was increased, and the incidence and severity of arthritis was reduced compared to arthritis induced in corn oil-fed mice. The females, especially those on the fish oil diet, tended to have less arthritis than the males. These alterations in the fatty acid pool available for PG and leukotriene synthesis suggest a pivotal role for the macrophage and PG in the immune and/or inflammatory response to type II collagen.
Exploring gender differences in literacy and mathematical understandings in the early years of school: Can differences be explained by behaviours in the classroom?

Gender differences in children’s early learning competence have been examined primarily through cross-sectional studies. Explanations for girls’ apparent advantage include earlier physical maturation and different social expectations placed on girls and boys from an early age. In analyses presented in this paper, differences in classroom behaviours (e.g., attentiveness and task persistence) are hypothesised as explaining gender differences in early academic outcomes. Data are drawn from Growing Up in Australia: The Longitudinal Study of Australian children (LSAC). LSAC is a cross-sequential cohort study funded by the Australian Government. Biennial data collection has been funded from 2004 (Wave 1) to 2010 (Wave 4). In these analyses, Wave 1 (2004) and Wave 2 (2006) data for 4464 children in the Kindergarten Cohort are used. Children, at Wave 2, were in the early years of formal school. They had a mean age of 6.8 years (SD= 0.24). Teachers rated children’s literacy and mathematical understandings on academic rating scales for literacy and language competence and mathematical thinking. Measures of classroom behaviour included a 6-item measure of approaches to learning and teaching ratings on the Strengths and Difficulties Questionnaire (SDQ). Regression analyses take account of children’s receptive language competence and emergent literacy skills at age 4 (LSAC Wave 1 data). Girls were found to have better learning outcomes, in particular, literacy and language outcomes that were significantly related to more positive classroom behaviours. Results are discussed with respect to the influence of children’s early classroom behaviours on academic learning at the beginning of formal schooling.
GPUSync: Architecture-Aware Management of GPUs for Predictable Multi-GPU Real-Time Systems

The integration of graphics processing units (GPUs) into real-time systems has recently become an active area of research. However, prior research on this topic has failed to produce real-time GPU allocation methods that fully exploit the available parallelism in GPU-enabled systems. In this paper, a GPU management framework called GPUSync is described that was designed with the goal of increasing parallelism in mind. GPUSync can be applied in multi-GPU real-time systems, is cognizant of the system bus architecture and afﬁnity among computational tasks and GPUs, and fully exposes the parallelism offered by modern GPUs, even when closed-source GPU drivers are used. In empirical evaluations presented herein involving real-world applications, GPUSync improved real-time response times by three times or more, on average, making previously unschedulable workloads schedulable.