Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of two local cowpea species for nutrient, antinutrient, and phytochemical compositions and organoleptic attributes of their wheat-based cookies

Background Childhood and adolescent malnutrition is a function of inadequate intake. Cookies are favourite snacks of children and adolescents. Objective This work determined the nutrient, antinutrient, and phytochemical compositions of two local cowpea (oraludi and apama) flours and evaluated the organoleptic properties of their wheat-based cookies. Design The two local cowpea species were processed into flours separately and blended with wheat on a 56-g protein basis. Chemical compositions of the processed cowpea flours were analysed using standard methods. Organoleptic attributes were evaluated with a nine-point Hedonic scale. Statistical analysis, which involved mean and standard deviations, were computed by analysis of variance, and Duncan's new multiple range tests were used to separate and compare group means of sensory evaluation data, with significance accepted at P<0.05. Results The results revealed that oraludi had superior percentage values compared to apama in protein (26.22 and 20.88), fat (7.98 and 6.65), and ash (3.81 and 3.13), while apama proved superior in moisture (9.76 and 7.82), crude fibre (5.49 and 4.91), and carbohydrate (54.09 and 49.26). The values were higher for oraludi than apama in iron (8.62 and 6.49 mg), zinc (1.61 and 0.95 mg), and beta-carotene (223.24 and 190.63 mg) but lower in sodium (34.79 and 56.72 mg), potassium (25.73 and 30.65 mg), phosphorus (13.35 and 18.26 mg), thiamine (5.33 and 9.41 mg), vitamin C (16.63 and 21.09 mg), and vitamin E (0.51 and 0.67 mg). Apama had 0.06 mg phytate, 0.09 mg oxalate, 15.22 mg tannins, 3.59 mg flavonoids, and 0.19 mg saponin. Oraludi had 0.03 mg phytate, 0.32 mg oxalate, 15.94 mg tannins, 3.14 mg flavonoid, and 0.13 mg saponin. Mean scores of general acceptability for wheat:apama (80:20) and wheat:oraludi:apama (60:20:20) cookies (7.71 and 7.41) were superior (P<0.05) to others. Conclusions Oraludi and apama proved nutrient dense. Their use improved the acceptability of some of the wheat-based cookies. Use of these local cowpeas in cookie production is, therefore, encouraged.
EBV-Encoded LMP1 Upregulates Igκ 3′Enhancer Activity and Igκ Expression in Nasopharyngeal Cancer Cells by Activating the Ets-1 through ERKs Signaling

Accumulating evidence indicates that epithelial cancer cells, including nasopharyngeal carcinoma (NPC) cells, express immunoglobulins (Igs). We previously found that the expression of the kappa light chain protein in NPC cells can be upregulated by the EBV-encoded latent membrane protein 1 (LMP1). In the present study, we used NPC cell lines as models and found that LMP1-augmented kappa production corresponds with elevations in ERKs phosphorylation. PD98059 attenuates LMP1-induced ERKs phosphorylation resulting in decreased expression of the kappa light chain. ERK-specific small interfering RNA blunts LMP1-induced kappa light chain gene expression. Luciferase reporter assays demonstrate that immunoglobulin κ 3′ enhancer (3′Eκ) is active in Igκ-expressing NPC cells and LMP1 upregulates the activity of 3′Eκ in NPC cells. Moreover, mutation analysis of the PU binding site in 3′Eκ and inhibition of the MEK/ERKs pathway by PD98059 indicate that the PU site is functional and LMP1-enhanced 3′Eκ activity is partly regulated by this site. PD98059 treatment also leads to a concentration-dependent inhibition of LMP1-induced Ets-1 expression and phosphorylation, which corresponds with a dose-dependent attenuation of LMP1-induced ERK phosphorylation and kappa light chain expression. Suppression of endogenous Ets-1 by small interfering RNA is accompanied by a decrease of Ig kappa light chain expression. Gel shift assays using nuclear extracts of NPC cells indicate that the transcription factor Ets-1 is recruited by LMP1 to the PU motif within 3′Eκ in vitro. ChIP assays further demonstrate Ets-1 binding to the PU motif of 3′Eκ in cells. These results suggest that LMP1 upregulates 3′Eκ activity and kappa gene expression by activating the Ets-1 transcription factor through the ERKs signaling pathway. Our studies provide evidence for a novel regulatory mechanism of kappa expression, by which virus-encoded proteins activate the kappa 3′ enhancer through activating transcription factors in non-B epithelial cancer cells.
Specificity and affinity of neuraminic acid exhibited by canine rotavirus strain K9 carbohydrate‐binding domain (VP8*)

The outer capsid spike protein VP4 of rotaviruses is a major determinant of infectivity and serotype specificity. Proteolytic cleavage of VP4 into 2 domains, VP8* and VP5*, enhances rotaviral infectivity. Interactions between the VP4 carbohydrate‐binding domain (VP8*) and cell surface glycoconjugates facilitate initial virus‐cell attachment and subsequent cell entry. Our saturation transfer difference nuclear magnetic resonance (STD NMR) and isothermal titration calorimetry (ITC) studies demonstrated that VP8*64‐224 of canine rotavirus strain K9 interacts with N‐acetylneuraminic and N‐glycolylneuraminic acid derivatives, exhibiting comparable binding epitopes to VP8* from other neuraminidase‐sensitive animal rotaviruses from pigs (CRW‐8), cattle (bovine Nebraska calf diarrhoea virus, NCDV), and Rhesus monkeys (Simian rhesus rotavirus, RRV). Importantly, evidence was obtained for a preference by K9 rotavirus for the N‐glycolyl‐ over the N‐acetylneuraminic acid derivative. This indicates that a VP4 serotype 5A rotavirus (such as K9) can exhibit a neuraminic acid receptor preference that differs from that of a serotype 5B rotavirus (such as RRV) and the receptor preference of rotaviruses can vary within a particular VP4 genotype.
Differences in the Predictors of Job Stress and Job Satisfaction for Black and White Jail Staff

ABSTRACT The importation model holds that certain personal characteristics, such as race, may shape employees’ views and may also influence how workplace factors affect them. Most correctional staff job stress and job satisfaction studies treat race/ethnicity as a dichotomous variable (i.e., White/Non-White) to be controlled for in multivariate analysis but have not explored if the effects of variables differ by racial groups. Thus, the effects of workplace variables may differ between Black and White correctional staff. Using survey data from staff at a large southern jail system, this study examined how personal characteristics (i.e., age, gender, educational level, and position) and workplace factors (i.e., role strain, perceived dangerousness of the job, instrument communication, input into decision making, and administrative support) predicted job stress and job satisfaction between Black and White staff. Results indicate that there were no significant differences in the effects between the two groups for job stress. For job satisfaction, however, there was a difference, with gender, position, and perceived dangerousness of the job having larger effects on White staff, and role strain, input into decision making, and administrative support having larger effects on Black staff.
Opportunistic Scheduling and Performance Analysis on Wireless Network Coding

Network coding has been shown to be able to improve the throughput and power efficiency of wireless networks by mixing packets from different flows into a single packet. However, forcing packets to be coded may induce large delay and packet loss rate which is intolerable to some services such as real-time communications. Considering the diversity of traffic flows and the stochastic nature of the packet arrival process in wireless networks, we propose an opportunistic scheduling called Probabilistic Network Coding with Priority (PNCP) method. The relay node can transmit either network-coded or un-coded packets. Service priority and queue state are the two most important facts that determine a packet's transmission with or without network coding. By using a Markov Chain model, the average packet delay and packet loss rate of PNCP are presented. We validate the theoretical results through simulations and demonstrate that it can serve different flows with priority. More importantly, we discuss the impact of different parameters on the performance of PNCP and show that the opportunistic scheduling can significantly reduce the packet loss rate and average delay.
Functional Imaging Studies of Neuropsychological Patients: Applications and Limitations

Functional imaging studies of neuropsychologically impaired patients have not enjoyed the immediate success that was attained by functional imaging studies of normal subjects. This is largely because it has taken time to appreciate some of the deeper issues surrounding study design, analysis and interpretation. The most significant limitation is that functional imaging experiments with patients need tasks that the patients can perform. This precludes direct investigations of the physiological correlates of cognitive deficits. Nevertheless, functional imaging studies of brain-damaged patients who retain task competence can provide information that is not available from structural imaging, behavioural assessments or functional imaging with normal subjects. This is because intact task performance, following a brain lesion, does not necessarily entail normal neuronal responses in undamaged cortical areas. Abnormal neuronal responses, in the context of normal performance, can indicate alternative neuronal and cognitive mechanisms for supporting the same task. This, in turn, has important implications for understanding the mechanisms that mediate recovery and the organizational principles that underlie functional architectures in the human brain.
Product Market Synergies and Competition in Mergers and Acquisitions: A Text-Based Analysis

We examine how product differentiation influences mergers and acquisitions and the ability of firms to exploit product market synergies. Using novel text-based analysis of firm 10K product descriptions, we find three key results. (1) Firms are more likely to enter restructuring transactions when the language describing their assets is similar to all other firms, consistent with their assets being more redeployable. (2) Targets earn lower announcement returns when similar alternative target firms exist. (3) Acquiring firms in competitive product markets experience increased profitability, higher sales growth, and increased changes in their product descriptions when they buy target firms that are similar to them and different from rival firms. Our findings are consistent with similar merging firms exploiting synergies to create new products and increase their product differentiation relative to ex-ante rivals.
Online simulation of emotional interactive behaviors with hierarchical Gaussian process dynamical models

The online synthesis of stylized interactive movements with high levels of realism is a difficult problem in computer graphics. We present a new approach for the learning of structured dynamical models for the synthesis of interactive body movements that is based on hierarchical Gaussian process latent variable models. The latent spaces of this model encode postural manifolds and the dependency between the postures of the interacting characters. In addition, our model includes dimensions representing emotional style variations (for neutral, happy, angry, sad) and individually-specific motion style. The dynamics of the state in the latent space is modeled by a Gaussian Process Dynamical Model, a probabilistic dynamical model that can learn to generate arbitrary smooth trajectories in real-time. The proposed framework offers a large degree of flexibility, in terms of the definition of the model structure as well as the complexity of the learned motion trajectories. In order to assess the suitability of the proposed framework for the generation of highly realistic motion, we performed a 'Turing test': a psychophysical study where human observers classified the emotions and rated the naturalness of the generated and natural emotional handshakes. Classification results for both stimulus groups were not significantly different, and for all emotional styles, except for neutral, participants rated the synthesized handshakes equally natural as animations with the original trajectories. This shows that the proposed method generates highly-realistic interactive movements that are almost indistinguishable from natural ones. As a further extension, we demonstrate the capability of the method to interpolate between different emotional styles.
A comparison of p53 and p16 expression in human tumor cells treated with hyperthermia or ionizing radiation

To assess the potential relationship between p53 and p16 proteins in the cellular response to stress, we have examined the levels of these proteins in a series of human tumor cell lines after treatment with either ionizing radiation or hyperthermia. We found that cells with abnormal radiation‐induced G1 arrest (non‐functional p53) had significantly higher constitutive levels of p16 than cells showing a normal G1 arrest (functional p53). Time‐course experiments were done to test the effect of γ‐irradiation on intracellular levels of p16. The pattern of changes in p16 response was similar in all cell lines studied, and p16 expression was not related to cellular sensitivity to radiation or to the level of p53 induction after treatment. We also provide evidence that short‐term exposure to high temperature causes p53 accumulation. Hyperthermia‐induced p53 accumulation was greatest in those cells exhibiting the highest radiation‐induced p53 accumulation, suggesting a possible relationship between p53 induction after these 2 different stresses. p16 synthesis was also induced in different cell lines after heat treatment, and this response was independent of p53 functionality. When we compared the level of p16 expression with the extent of G0/G1 arrest induced by heat, a linear correlation was found, raising the possibility that p16 may be involved in the control of cell cycle progression in response to heat treatment. Int. J. Cancer 72:307–312, 1997. © 1997 Wiley‐Liss, Inc.
Hierarchical Processing of Face Viewpoint in Human Visual Cortex

The ability to recognize objects across different viewpoints (view invariance) is a remarkable property of the primate visual system. According to a prominent theory, view information is represented by view-selective mechanisms at early stages of visual processing and gradually becomes view invariant in high-level visual areas. Single-cell recording studies have also reported an intermediate step of partial view invariance for mirror-symmetric face views. Nevertheless, similar evidence for this type of hierarchical processing for face view has not been reported yet in the human visual cortex. The present functional magnetic resonance imaging study used state-of-the-art multivariate pattern analysis to explore face-view tuning in the human visual cortex. Our results revealed that consistent with a view-selective representation, face view can be successfully decoded in face and object-selective regions as well as in early visual cortex. Critically, similar neural representations for mirror-symmetric views were found in high-level but not in low-level visual areas. Our results support the notion of gradual emergence of view-invariant representation with invariance for mirror-symmetric images as an intermediate step and propose putative neural correlates of mirror-image confusion in the human brain.
Hippocampal volume and depression: a meta-analysis of MRI studies.

OBJECTIVE Several studies have found reduced hippocampal volume in patients with unipolar depression, but discrepancies exist. The authors performed a systematic review and meta-analysis of volumetric studies of the hippocampus in patients with mood disorders. METHOD Studies of hippocampal volume in unipolar and bipolar patients were identified. A meta-analysis of the 12 studies of unipolar depression fulfilling specific criteria was performed. The sample comprised 351 patients and 279 healthy subjects. RESULTS The studies were highly heterogeneous regarding age and gender distribution, age at onset of the disorder, average number of episodes, and responsiveness to treatment, but the pooled effect size of depression was significant in both hemispheres for the unipolar patients. The weighted average showed a reduction of hippocampal volume of 8% on the left side and 10% on the right side. The causes of the heterogeneity were analyzed, and a meta-regression showed that the total number of depressive episodes was significantly correlated to right but not left hippocampal volume reduction. CONCLUSIONS Hippocampal volume is reduced in patients with unipolar depression, maybe as a consequence of repeated periods of major depressive disorder. Bipolar patients did not seem to show a reduction in hippocampal volume, but this has been much less investigated.
Monitoring Changes in Rice Cultivated Area from SAR and Optical Satellite Images in Ben Tre and Tra Vinh Provinces in Mekong Delta, Vietnam

The objective of this study was to obtain up-to-date information on land use and to identify long term changes in land use, especially rice, aquaculture and other crops in Ben Tre and Tra Vinh provinces in Vietnam’s Mekong Delta. Long-term changes in land-use of the study area have not been studied using long time series of SAR and optical Earth observation (EO) data before. EO data from 1979–2012 was used: ENVISAT ASAR Wide Swath Mode, SPOT and Landsat imagery. An unsupervised ISODATA classification was performed on multitemporal SAR images. The results were validated using ground truth data. Using the Synthetic Aperture Radar (SAR) imagery maps for 2005, 2009 and 2011 were obtained. Different rice crops, aquaculture and fruit trees could be distinguished with an overall accuracy of 80%. Using available optical imagery the time series was extended from 2005 to 1979. Long-term decrease in the rice acreage and increase in the aquaculture acreage could be detected.
Moral reasoning in women with posttraumatic stress disorder related to childhood abuse

Background Preliminary evidence suggests that relative to healthy controls, patients with posttraumatic stress disorder (PTSD) show deficits on several inter-related social cognitive tasks, including theory of mind, and emotion comprehension. Systematic investigations examining other aspects of social cognition, including moral reasoning, have not been conducted in PTSD stemming from childhood trauma. Objective To conduct a comprehensive assessment of moral reasoning performance in individuals with PTSD stemming from childhood abuse. Method Moral reasoning performance was assessed in 28 women with PTSD related to prolonged childhood trauma and 19 matched healthy controls. Performance was assessed using 12 modified moral dilemmas and was queried in three domains: utilitarian/deontological sacrificial dilemmas (personal and impersonal), social order vs. compassion, and altruism vs. self-interest. Participants were asked whether a proposed action was morally acceptable or unacceptable and whether or not they would perform this action under the circumstances described. Results Women with PTSD were less likely to carry out utilitarian actions in personal, sacrificial moral dilemmas, a choice driven primarily by consequential intrapersonal disapproval. Increased concern regarding intrapersonal disapproval was related to higher symptoms of guilt in the PTSD group. Patients with PTSD demonstrated less altruistic moral reasoning, primarily associated with decreased empathic role-taking for beneficiaries. Conclusions Women with PTSD due to childhood trauma show alterations in moral reasoning marked by decreased utilitarian judgment and decreased altruism. Childhood trauma may continue to impact moral choices made into adulthood. Highlights of the article Moral judgment processing was found to be altered in women with PTSD related to chronic childhood trauma. In comparison to healthy women, women with PTSD were less likely to approve utilitarian actions when required to assume their agency in dilemmas involving the infliction of direct physical harm. Decreased likelihood of utilitarian action approval by the PTSD sample was driven by significantly enhanced endorsement of guilt and shame as consequences of such actions. Endorsement of guilt and shame in moral dilemmas was related to increased severity of current clinical symptoms of guilt.
Cx43 expressed on bone marrow stromal cells plays an essential role in multiple myeloma cell survival and drug resistance

Introduction Connexin-43 (Cx43), a connexin constituent of gap junctions (GJs) is mainly expressed in bone marrow stromal cells (BMSCs) and played a important role on hematopoiesis. In this study, we explored the role of gap junctions (GJs) formed by Cx43 between BMSCs and multiple myeloma (MM) cells. Material and methods qPCR and western blot assays were employed to assay Cx43 expression in three MM cell lines (RPMI 8266, U266, and XG7), freshly isolated MM cells, and bone marrow stromal cells (BMSCs). Cx43 mRNA and proteins were detected in all three MM cell lines and six out of seven freshly isolated MM cells. Resuths The BMSCs from MM patients expressed Cx43 at higher levels than of normal donor (ND-BMSCs). Dye transfer assays demonstrated that gap junction intercellular communication (GJIC) occurring via Cx43 situated between MM and BMSCs is functional. Cytometry beads array (CBA) assays showed that cytokines production changed when the ND-BMSCs were co-cultured with MM cells, especially the levels of IL-6, SDF-1α and IL-10 were higher than those the cells cultured alone and decreased significantly in the presence of GJ inhibitor heptanol. Our results demonstrated that the cytotoxicity of BTZ to MM cells decreased significantly in the presence of BMSCs, an effect that was partially recovered in the presence of GJ inhibitor. Conclusions Our data suggest that GJIC between MM and BMSCs is a critical factor in tumor cell proliferation and drug sensitivity, and is implicated in MM pathogenesis.
Innovation through interactive crowdsourcing: The role of boundary objects

The aim of this study is to explore company–consumer collaboration in the innovation process through the practice of interactive crowdsourcing. This type of crowdsourcing lies within the co-creation process and is characterized by close interactions between the two categories of actors. To pursue our aim, we draw on the concept of “boundary object,” developed within sociology. This concept can help understand the dynamics of interactions and collective action among disparate actors. The study’s findings show that boundary objects and boundary negotiating artifacts facilitate the exchange of knowledge and expertise between the world of companies and the world of consumers. They also highlight the role of these objects in revealing influence and power games liable to generate disappointment and tensions between actors. The study sheds new light on the advantages, limitations, and challenges of a co-creation process.