Miracle-dz/UniFAR-FTUs huggingface dataset:
Lexical access in spoken word production by bilinguals: evidence from the semantic competitor priming paradigm

The competitive nature of the lexical selection process during spoken word production is well established in monolinguals. In this paper we explore the implication of this process for spoken word production in bilinguals. A cross-language semantic competitor priming effect was demonstrated, which shows that cross-language lexical competition is a feature of the word production system of the unbalanced English–French bilinguals who participated in the experiment. Experimental evidence was also found which suggests that a selected language bias effected through inhibition of the unwanted language plays an important role in resolving the cross-language lexical competition during bilingual word production in a selected language. The data further suggest that the dominance of the unwanted language relative to the selected language determines the presence/absence or “strength” of inhibition through which the selected language bias is effected. These findings are also interpreted in terms of a recent language-specific lexical selection account of bilingual lexical access.
The Term Structure of Real Interest Rates: Theory and Evidence from UK Index-Linked Bonds

Abstract This paper studies the behavior of the default-risk-free real term structure and term premia in two general equilibrium endowment economies with complete markets but without money. In the first economy there are no frictions as in Lucas (Econometrica 46 (1978) 1429) and in the second risk-sharing is limited by the risk of default as in Alvarez and Jermann (Econometrica 68 (2000) 775; Rev. Financial Studies 14 (2001) 1117). Both models are solved numerically, calibrated to UK aggregate and household data, and the predictions are compared to data on real interest rates constructed from the UK index-linked data. While both models produce time-varying risk or term premia, only the model with limited risk-sharing can generate enough variation in the term premia to account for the rejections of expectations hypothesis.
Pathways for Emotions and Attention Converge on the Thalamic Reticular Nucleus in Primates

How do emotional events readily capture our attention? To address this question we used neural tracers to label pathways linking areas involved in emotional and attentional processes in the primate brain (Macaca mulatta). We report that a novel pathway from the amygdala, the brain's emotional center, targets the inhibitory thalamic reticular nucleus (TRN), a key node in the brain's attentional network. The amygdalar pathway formed unusual synapses close to cell bodies of TRN neurons and had more large and efficient terminals than pathways from the orbitofrontal cortex and the thalamic mediodorsal nucleus, which similarly innervated extensive TRN sites. The robust amygdalar pathway provides a mechanism for rapid shifting of attention to emotional stimuli. Acting synergistically, pathways from the amygdala and orbitofrontal cortex provide a circuit for purposeful assessment of emotional stimuli. The different pathways to TRN suggest distinct mechanisms of attention to external and internal stimuli that may be differentially disrupted in anxiety and mood disorders and may be selectively targeted for therapeutic interventions.
Self-determination theory: a framework for the recovery paradigm

Recovery is an increasingly important concept in mental health services research and policy-making. However, despite burgeoning interest in the concept, no overarching theoretical or empirical framework has been offered to support its key ideas. Further, it is often unclear how recovery ideas translate into routine practices of mental health programmes and practitioners. In this article, a theoretical framework for recovery ideas is derived from self-determination theory, a widely researched and empirically validated theory of human need fulfilment. I discuss the conceptual overlap of self-determination theory and recovery ideas, and, using key motivational concepts, develop a typology of recovery-oriented practices for three hypothetical programme types (controlling, traditional/paternalistic and recovery oriented). I describe existing measures of recovery-oriented practice and consider the implications of self-determination theory for measurement of and research on recovery-oriented practice.
Magnocellular facilitation of flanked-letter identification disappears with strong flanker interference

Previously, we obtained evidence to suggest that the magnocellular system may reduce interference from flankers during flanked-letter identification. To understand this phenomenon better, we combined the data of our previous experiments, which all used the same flanking letter, and focused on the different target letters that were used. The new analysis showed that after an initial increase, magnocellular facilitation decreased and ultimately disappeared, as the target–flanker combination's level of interference increased. The initial increase was partly while the later decrease was fully replicated in two new experiments that focused on two different target letters while manipulating flanker identity. The outcome of a third new experiment studying the type of interference reduced suggested that although crowding contributed to total interference, it was insensitive to magnocellular mediation. Our results may be understood to reflect the involvement of the magnocellular system in an attentional-selection mechanism that is silenced by surround suppression.
Therapeutic Implications of KIT in Melanoma

AbstractMelanoma is a heterogeneous disease representing distinct biologic and genetic subsets. Activating mutations in KIT have been discovered in a significant proportion of melanomas arising from acral, mucosal, and chronically sun-damaged sites and represent an important melanoma genetic subset. Initially, KIT was believed to function as a tumor suppressor, but additional research suggests that, in certain contexts, KIT functions as an oncogene. Therapeutic strategies targeting KIT with imatinib demonstrated remarkable efficacy in patients with gastrointestinal stromal tumors, but initial trials in melanoma were unsuccessful. Nevertheless, case reports continued to surface that demonstrated the remarkable efficacy of imatinib for patients with specific KIT genetic aberrations. Recently, trials of imatinib have selected patients with KIT genetic aberrations and have shown promising results. Current efforts are investigating additional agents that target KIT and testing KIT inhibitors in combination with other agents to improve the outcome for patients with this genetic subset of melanoma.
A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction

It is proposed that caloric restriction (CR) increases mitochondrial biogenesis. However, it is not clear why CR increases an energetically costly biosynthetic process. We hypothesized that 40% CR would decrease mitochondrial protein synthesis and would be regulated by translational rather than transcriptional mechanisms. We assessed cumulative mitochondrial protein synthesis over 6 weeks and its transcriptional and translational regulation in the liver, heart, and skeletal muscle of young (6 month), middle (12 month), and old (24 month) male B6D2F1 mice that were lifelong CR or ad lib (AL) controls. Mitochondrial protein synthesis was not different between AL and CR (fractional synthesis over 6 weeks (range): liver, 91–100%; heart, 74–85%; skeletal muscle, 53–72%) despite a decreased cellular proliferation in liver and heart with CR. With CR, there was an increase in AMP‐activated protein kinase phosphorylation/total (P:T) in heart and liver, and an increase in peroxisome proliferator‐activated receptor gamma coactivator 1‐α mRNA in all tissues, but not protein. Ribosomal protein S6 was decreased with CR. In conclusion, CR maintained mitochondrial protein synthesis while decreasing cellular proliferation during a time of energetic stress, which is consistent with the concept that CR increases somatic maintenance. Alternative mechanisms to global translation initiation may be responsible for selective translation of mitochondrial proteins.
Obstacles to the successful development of an efficacious T cell‐inducing HIV‐1 vaccine

An efficacious vaccine to HIV‐1 is direly needed to stem the global pandemic. Immunogens that elicit broadly cross‐neutralizing antibodies to HIV‐1 remain elusive, and thus, most HIV‐1 vaccine efforts are focusing on induction of T cells. The notion that T cells can mediate protection against HIV‐1 has been called into question by the failure of the STEP trial, which was designed to test this concept by the use of an E1‐deleted Ad vaccine carrier. Lack of efficacy of the STEP trial vaccine underscores our limited knowledge about correlates of immune protection against HIV‐1 and stresses the need for an enhanced commitment to basic research, including preclinical and clinical vaccine studies. In this review, we discuss known correlates of protection against HIV‐1 and different vaccine strategies that have been or are being explored to induce such correlates, focusing on T cell‐inducing vaccines and particularly on Ad vectors.
The Impact of a Professional Development Programme on Teachers' Attitudes towards Inclusion.

This article describes a study that aimed to answer the following question: 'Will a programme of professional development in the area of special and inclusive education be effective in achieving attitudinal shift in teachers? ' Forty-eight teachers who were enrolled on a Master's programme in Special and Inclusive Education were surveyed via a questionnaire at the beginning and end of a ten-week introductory module. The results indicated overall attitudinal shift and attitudinal shift for four categories of inclusion to suggest more positive attitudes at the end of the module, compared with at the beginning. The implications for providers of pre- and in-service education and training courses for teachers are discussed. [ABSTRACT FROM AUTHOR]
Nociceptive Sensitivity and Opioid Antinociception and Antihyperalgesia in Freund's Adjuvant-Induced Arthritic Male and Female Rats

The present study was designed to examine sex differences in complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia and sex differences in opioid antinociception and anti-hyperalgesia. Female rats developed inflammation and hyperalgesia faster and exhibited greater peak hyperalgesia than male rats. In arthritic (CFA-treated) rats, lower thresholds were observed during estrus and proestrus, and in nonarthritic (vehicle-treated) rats, lower thresholds were observed during proestrus. Morphine and oxycodone were more potent in male than female arthritic rats, and butorphanol was more potent and effective in male than female arthritic rats. The potency of morphine was increased in arthritic rats, although to a greater magnitude in males. The potency of oxycodone was increased in male but not female arthritic rats. The potency of butorphanol was increased in arthritic male rats and the maximal antinociceptive effect of butorphanol was increased in arthritic female rats, but it did not result in greater than 20% antinociception. Morphine, oxycodone, and butorphanol all produced antihyperalgesic effects (returning thresholds of arthritic rats to the thresholds of nonarthritic rats) with greater potency in males than females. The peripherally acting opioid agonist loperamide produced intermediate levels of antinociception in male and female arthritic rats and no antinociception in nonarthritic rats. Loperamide was more potent in male than female arthritic rats at producing antihyperalgesia. These data demonstrate sex differences in arthritis-induced hyperalgesia and responsiveness to opioid analgesics. In arthritic rats, the antinociceptive effects of opioid agonists are most probably mediated by both central and peripheral opioid receptors, whereas their antihyperalgesic effects are mediated primarily by actions at peripheral opioid receptors.
Automatic-Spreading Activation Effects following Children's Reading of Complete Sentences

Third-, sixth-, and college-grade level students participated in an on-line reading task that incorporated both a naming latency and a subsequent cued-recall memory requirement. Following reading of a complete sentence, latency for naming a target word was measured in which the target word was either (a) a repetition of a word in the previous sentence, (b) an associate of a word in the previous sentence, (c) inferable from the integrated meaning of words in the previous sentence, or (d) unrelated to words in the previous sentence. Increased speed was found for naming words presented in the repeated, associated, and inferred target conditions as compared to the unrelated word condition. In each case, the observed facilitation effect was of greater magnitude for the younger readers. In the cued-recall task, single-word cues resulted in better recall memory performance when the cue had been explicitly presented in a prior sentence as compared to cues which were only inferable from previously read material. Results were interpreted in terms of context effects which extend beyond sentence completion boundaries and in terms of developmental differences in automatic expectancy and semantic integration effects.
Modulation of interpersonal trust in borderline personality disorder by intranasal oxytocin and childhood trauma

Borderline personality disorder (BPD) is characterized by interpersonal difficulties, whereby patients are negatively biased concerning the evaluation of others' trustworthiness. Here, we examined the effect of oxytocin on interpersonal behavior of BPD patients in a trust game, emphasizing the assessment of facial attractiveness of the patients' counterparts in the game, and patients' history of childhood trauma. Thirteen BPD patients and thirteen healthy controls played a trust game after receiving oxytocin or placebo in a randomized, double-blind crossover design. Childhood trauma was evaluated using the Childhood Trauma Questionnaire (CTQ). Patients transferred less money in the oxytocin condition compared to placebo. While healthy controls transferred more money units (MUs) to attractive counterparts than to unattractive ones only after the administration of oxytocin, BPD patients showed this pattern in both conditions. Emotional neglect during childhood negatively correlated with the amount of MUs transferred by patients under oxytocin, but not placebo. Oxytocin had a trust-lowering effect in BPD, which was correlated with patients' history of childhood trauma. Patients' evaluation of interpersonal trust seems to depend more on attractiveness features of their counterparts than in controls, a finding that may have important implications for further research on the usefulness of “prosocial” peptides as an adjunct to psychotherapeutic interventions.
Hepatic venous pressure gradient to assess fibrosis and its progression after liver transplantation for HCV cirrhosis

Progression of fibrosis following recurrent hepatitis C virus (HCV) infection is frequent after liver transplantation (LT). Histology remains the gold standard to assess fibrosis, but the value of hepatic venous pressure gradient (HVPG) is being explored. We evaluated patients with recurrent HCV infection after LT to assess whether HVPG correlates with liver histology, particularly fibrosis. A total of 90 consecutive patients underwent 170 HVPG measurements concomitant with transjugular liver biopsy (TJB), with 31.5 (range, 6–156) months of follow up. Median biopsy length was 22 mm and total portal tract count was 12 (complete 6, partial 6). Median HVPG was 4 mmHg: 38% of patients ≥6 mmHg (portal hypertension, PHT), 13% ≥10 mmHg. HVPG correlated with Ishak stage (r = 0.73, P < 0.001) for mild (0–3) and severe fibrosis (4–6), and grade score (r = 0.47, P < 0.001), but neither correlated with interval from LT nor biopsy length. HVPG was ≥10 mmHg in 15 patients: 12 had stage 5 or 6, and 3 severe portal expansion. HVPG was repeated in 49, between 7 and 60 months with weak correlation to fibrosis score (r = 0.30, P = 0.045). A total of 12 patients with HVPG ≥6 mmHg had fibrosis score ≤3, while 8 patients had normal HVPG but fibrosis stage ≥4. These discrepancies were mostly associated with specific histological features such as perisinusoidal fibrosis rather than errors in measuring HVPG. In 29 with HVPG <6 mmHg at 1 yr, none decompensated compared to 4 of 13 (31%) with PHT. In conclusion, HVPG correlates with fibrosis and its progression, due to recurrent HCV infection, assessed in TJB. Liver Transpl 13:1305–1311, 2007. © 2007 AASLD.
Cerebral palsy of cystic periventricular leukomalacia in low‐birth‐weight infants

We studied ultrasound findings and neurodevelopmental outcome of 24 infants weighing 2500 g or less with cystic periventricular leukomalacia. Fourteen infants had symmetrical cysts in the parietal or occipital region (group 1) and 10 had non‐symmetrical cysts (group 2). Each infant was followed for more than 4 years of age (mean 5 years and 7 months). Twenty out of 24 (83.3%) children developed cerebral palsy. All of group 1 had cerebral palsy (8 diplegia and 6 ataxic diplegia), while 6 (60%) in group 2 developed cerebral palsy (4 diplegia and 2 hemiplegia). There was a significant difference in the incidence of cerebral palsy and motor ability between the two groups. The size and site of the cyst did not predict cerebral palsy. The presence of symmetrical cysts in the parietal or occipital region is a highly reliablable neurosonographic finding for predicting cerebral palsy.
Yield and quality responses of drip-irrigated spinach to different irrigation quantities in a semi-arid region with a high altitude

The effect of different irrigation quantities on the growth, marketable yield, crop quality (antioxidant activity, mineral and total phenolic content) and irrigation water use efficiency (IWUE) of spinach grown in a semi-arid region of high altitude (1795 m a.s.l.) was determined. Plants were irrigated with three different irrigation quantities which determined considering 100 (I1), 85 (I2) and 70% (I3) of the evaporation obtained from a Class A pan. Irrigation quantities in the I1, I2 and I3 treatments as two years average were 290, 264.3 and 238.6 mm, respectively. The I1 treatment provided the highest growth, marketable yield (28.06 t*ha-1) and IWUE (9.7 kg*m-3). However, mineral and total phenolic content and antioxidant activity in the leaves of spinach were significantly higher under lower water application conditions. The I2 treatment resulted with the highest antioxidant activity and content of N, K, Mg, Na, Fe, Cu and total phenolics. As a result of the study, I1 treatment in spinach production could be suitable for water sufficient regions due to higher yield and IWUE. However, I2 treatment may be more appropriate for water scarce semi-arid regions of high altitude for obtaining higher minerals and antioxidant activity.
Aspects of Coalition Payoffs in European Parliamentary Democracies

One important proposition about the distribution of coalition payoffs is found in W. A. Gamson's theory of coalition formation: “Any participant will expect others to demand from a coalition a share of the payoff proportional to the amount of resources which they contribute to a coalition. ” This proposition is tested in a universe of cabinet coalitions existing in thirteen European democracies during the postwar period. Here, payoffs to partners are indicated by the percentage share of cabinet ministries received by parties for their percentage contribution of parliamentary seats/votes to the coalition. The proportionality proposition is shown to hold strongly. Disproportionality, however, is observed to occur in distributions at the extremities of party size—large parties tend to be proportionately underpaid and small parties overpaid, the larger or smaller they become. This effect, however, is most pronounced when the size of the coalition is small, and tends to reverse itself as the size of the coalition increases.
High-Stakes Testing Accommodations: Validity Versus Disabled Rights

Traditionally, measurement specialists have provided testing accommodations for examinees with physical disabilities such as blindness or impaired mobility. Following passage of the Americans with Disabilities Act of 1990, advocates for the disabled have argued that federal law also requires testing accommodations for mental disabilities such as dyslexia and other learning disabilities. Such requested accommodations have included readers, calculators, word processors, and additional time. But these accommodations may affect test validity, requiring measurement specialists to balance the social goal of integrating the disabled against the measurement goal of accurate test score interpretation. Although the courts have provided some guidance regarding testing accommodation requirements for the disabled, they have not yet addressed the issue of where to draw the line on accommodations for mental disabilities. This article explores the measurement problems associated with granting accommodations for mental di.
The Relationship between Collective Efficacy and Performance in Manufacturing Work Teams

This study explores the construct of collective efficacy for self-managed work teams in a manufacturing setting. The construct is developedfrom a historical perspective through the team literature and the self-efficacy literature. Collective efficacy and performance behaviors are measured at four time periods for eight work teams. A positive relationship was discovered using repeated measures analysis of variance, indicating that higher efficacy is related to higher levels of performance.
Monopoly Pricing 3 with Network Externalities Law and Economics Consulting Group

How should a monopolist price a durable good or a new technology that is subject to network externalities? In particular, should the monopolist set a low \introductory price" to attract a \critical mass" of adopters? In this paper, we provide intuition as to when and why introductory pricing might occur in the presence of network externalities. Incomplete information about demand or asymmetric information about costs is necessary for introductory pricing to occur in equilibrium when consumers are small. We are grateful to Joe Farrell, Arthur Fishman, Kai-Uwe K uhn, Jorge Padilla, three referees, and seminar participants at CORE, Tel Aviv University, University of Toulouse (ASSET Meeting) and University of California at Berkeley for useful comments and suggestions. The usual disclaimer applies.
Ability Grouping: year group differences in self‐concept and attitudes of secondary school pupils

Abstract The vast international literature on the effects of different types of ability grouping on self‐concept and pupils' attitudes towards school has focused on pupils from single year groups. This article aimed to explore year group differences in pupils' self‐concept and attitudes towards school as influenced by ability grouping. The study was cross‐sectional in design and measured attitudes towards school and mathematics, general and school self‐concept and preferences for different kinds of grouping in 234 pupils from years 7 through 10 attending a mixed comprehensive school. The findings indicated that mathematics self‐concept was consistently lower than school and general self‐concept; all aspects of self‐concept increased up to Year 9 and then declined in Year 10, pupils in the higher sets tended to have higher self‐concepts; pupil preferences for setting were greater in the higher year groups, as was the extent to which the top set was perceived to be the best. A substantial proportion of pupils wanted to move set, usually to a higher set. Set placement itself did not appear to have a consistent effect on attitudes towards mathematics. This seemed to be mediated by the quality of teaching.