Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic weight loading in older people with hip fracture.

OBJECTIVE Hip fractures have a high morbidity and mortality in elderly patients. Improving mobility outcomes is crucial in order to decrease the burden of this injury. The objective of this study was to investigate dynamic weight loading in older people with hip fractures using a new device. DESIGN In an observational study, low-energy hip fracture patients were monitored one day per week with the FeetB@ck system during their admission. Pain, gait and balance scores were noted. Outcome measures of the FeetB@ck system are steps, walking bouts and loading rate. RESULTS A total of 21 patients with hip fracture were included in the study (mean age 80.3 years (standard deviation 8.3 years)). The number of steps, walking bouts and loading rate had a positive linear relationship with rehabilitation (i.e. gait and balance scores) (p < 0.05). These parameters also differed significantly between patients with short (less than 8 weeks, n = 7), intermediate (between 8 and 12 weeks, n = 8) and long (longer than 12 weeks, n = 6) of rehabilitation (p < 0.01). CONCLUSION The loading rate is a sensitive weight loading parameter for analysis of dynamic weight loading during rehabilitation in elderly hip fracture patients. This parameter correlates with clinical improvement and can differentiate between fast and slow rehabilitation.
Properties of the Aftershock Sequence of the 1999 Mw 7.1 Hector Mine Earthquake: Implications for Aftershock Hazard

We investigate the spatial and temporal seismicity parameters and the related probabilistic aftershock hazard for the aftershock sequence of the 1999 M_w 7.1 Hector Mine mainshock and compare it with the neighboring 1992 M_w 7.3 Landers sequence. Using a catalog of 11,000 earthquakes, we determine the earthquake size distribution (b-value), the aftershock decay rate (p-value), and the seismic activity rate (a-value). The b-values are high (b > 1.2) within the rupture area, significantly lower (b ≈ 0.7) north of the rupture area, and increase with time since the mainshock. Probabilistic aftershock hazard maps, computed automatically as early as 4 days after the mainshock, identified the northernmost part of the sequence as the highest-hazard region. These maps show a good agreement between the forecasts and the recorded large aftershocks. Based on the asymmetrical b-value and hazard patterns for both the Hector Mine and Landers sequences, we hypothesize that the mainshock rupture directivity and slip distribution influence aftershock hazard. Current static or dynamic stress triggering models cannot resolve this spatial and temporal evolution of the hazard. Stress tensor inversions of 1400 relocated first-motion focal mechanisms show predominantly a strike-slip stress state with a SW–NE trend of the greatest principal stress. The heterogeneity of the stress field is unusually high near the Hector Mine and Landers mainshock ruptures, particularly near patches of large slip.
Partial discharge modeling and induced charge concept: Comments and criticism of pedersen's model and associated measured transients

The capacitive network representation of voids in electric power cables has long been used for the study of the transients generated by a breakdown in an enclosed void. As an alternative to the capacitive representation of the void, the induced charge concept has been introduced by Pedersen and his colleagues. This work examines the induced charge concept from an electrostatic point of view and from measured transients in relation to the change in the capacitance of the system by opposing Pedersen's views.
An Unusual Pattern of Ligand-Receptor Interactions for the α7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline

The α7 nicotinic acetylcholine receptor shows broad pharmacology, complicating the development of subtype-specific nicotinic receptor agonists. Here we use unnatural amino acid mutagenesis to characterize binding to α7 by the smoking cessation drug varenicline (Chantix; Pfizer, Groton, CT), an α4β2-targeted agonist that shows full efficacy and modest potency at the α7 receptor. We find that unlike binding to its target receptor, varenicline does not form a cation-π interaction with TrpB, further supporting a unique binding mode for the cationic amine of nicotinic agonists at the α7 receptor. We also evaluate binding to the complementary face of the receptor’s binding site by varenicline, the endogenous agonist acetylcholine, and the potent nicotine analog epibatidine. Interestingly, we find no evidence for functionally important interactions involving backbone NH and CO groups thought to bind the canonical agonist hydrogen bond acceptor of the nicotinic pharmacophore, perhaps reflecting a lesser importance of this pharmacophore element for α7 binding. We also show that the Trp55 and Leu119 side chains of the binding site’s complementary face are important for the binding of the larger agonists epibatidine and varenicline, but dispensable for binding of the smaller, endogenous agonist acetylcholine.
Asynchronous Distributed Hypothesis Testing in the Presence of Crash Failures

This paper addresses the problem of distributed hypothesis testing in multi-agent networks, where agents repeatedly collect local observations about an unknown state of the world, and try to collaboratively detect the true state through information exchange. We focus on the impact of failures and asynchrony (two fundamental factors in distributed systems) on the performance of consensus-based non-Bayesian learning. In particular, we consider the scenario where the networked agents may suffer crash faults, and messages delay can be arbitrarily long but finite. We identify the minimal global detectability of the network for non-Bayesian rule to succeed. In addition, we obtain a generalization of a celebrated result by Wolfowitz and Hajnal to submatrices, which might be of independent interest.
What's new with WhatsApp & Co.? Revisiting the Security of Smartphone Messaging Applications

In recent years mobile messaging and VoIP applications for smartphones have seen a massive surge in popularity, which has also sparked the interest in research related to the security of these applications. Various security researchers and institutions have performed in-depth analyses of specific applications or vulnerabilities. This paper gives an overview of the status quo in terms of security for a number of selected applications in comparison to a previous evaluation conducted two years ago, as well as performing an analysis on some new applications. The evaluation methods mostly focus on known vulnerabilities in connection with authentication and validation mechanisms but also describe some newly identified attack vectors. The results show a predominantly positive trend for new applications, which are mostly being developed with robust security and privacy features, while some of the older applications have shown little to no progress in this regard or have even introduced new vulnerabilities in recent versions.
Gaming for Safer Sex: Young German and Turkish People Report No Specific Culture-Related Preferences Toward Educational Games Promoting Safer Sex.

OBJECTIVE Comprehensive sex education programs specifically designed for adolescents and young adults that take into account gender norms and cultural background have shown promise as a means of countering the high sexually transmitted infection rate in young people. Recently, digital gaming interventions delivered on computers or mobile devices have emerged as another way to promote safer sex behavior in a young population. Tailoring these computer-based interventions to their target population has been recognized to increase positive behavior outcomes. In this qualitative study, we investigated whether young female and male adults from two different cultural backgrounds (all living in Germany) would have different preferences and needs in relation to an educational game promoting safer sex. MATERIALS AND METHODS We conducted four semistructured focus group interviews comprising open-ended questions with male and female participants who had either a German or a Turkish background. In total, 20 individuals, aged between 18 and 22 years, from two socially diverse and ethnically mixed vocational schools in Germany participated. RESULTS Independent of cultural background and gender, participants preferred a real-world design with a first-person visual perspective over a fantasy-like third-person perspective. Furthermore, they preferred highly customizable avatars. All participants mentioned the importance of including an alcohol-intoxicated avatar and most participants wanted there to be additional information available about various safer sex approaches and about the use of different barrier protection methods. Males and females reported similar preferences for the design of an educational game promoting safer sex, with the only difference being exactly how the topic of having sexual intercourse should be addressed in the game. Males preferred a direct approach, whereas females had a preference for treating this subject more sympathetically. CONCLUSION Educational games offer anonymity and can provide young people across different cultural backgrounds with gender-tailored opportunities to experiment with specific safer sex precautions in a nonthreatening virtual environment, free from unwanted parental control and peer monitoring.
The effect of woody fuel characteristics on fuel ignition and consumption: a case study from a eucalypt forest in south-west Western Australia

Coarse woody debris (>0.6 cm in diameter) is an important component of the fuel complex in Australian eucalypt forests, influencing both fire behaviour, smoke production and post-fire ecological processes. We investigated how physical characteristics of woody fuel affected ignition and consumption during an experimental fire where the fuel complex characteristics, fire weather and fire behaviour varied within a narrow range. Decay status, bark condition, arrangement, suspension and extent of charring were classified for 2866 coarse woody fuel particles. We used generalised linear model (GLM) analysis to explain ignition success and the extent of consumption of individual particles, with a focus on larger diameter fuels (>7.5 cm in diameter), which comprised 83% of the woody fuel load and 94% of the woody fuel consumed during the flaming and smouldering stages of combustion. Ignition success was best explained by a model that included fuel arrangement (a surrogate of fuel proximity), suspension and decay status. The extent of fuel consumption was greater for pieces in advanced stages of decay, but suspension (inversely related) and arrangement (directly related) also affected the outcome. Forest management practices, previous fire history and other natural disturbances are likely to influence the distribution of pre-fire diameters and suspension classes that characterise large woody fuels at a site, and will therefore influence woody fuel consumption. This has practical implications for quantifying heat release and atmospheric emissions from fires burning in forests with different management histories.
Comparison of Replication-Competent Molecular Clones of Porcine Endogenous Retrovirus Class A and Class B Derived from Pig and Human Cells

ABSTRACT Vertically transmitted endogenous retroviruses pose an infectious risk in the course of pig-to-human transplantation of cells, tissues, and organs. Two classes of polytropic type C porcine endogenous retroviruses (PERV) which are infectious for human cells in vitro are known. Recently, we described the cloning and characterization of replication-competent PERV-B sequences from productively infected human cells (F. Czauderna, N. Fischer, K. Boller, R. Kurth, and R. R. Tönjes, J. Virol. 74:4028–4038, 2000). Here, we report the isolation of infectious molecular PERV-A and PERV-B clones from pig cells and compare these proviruses with clones derived from infected human 293 cells. In addition to clone PERV-A(42) derived from 293 cells, four “native” full-length proviral PERV sequences derived from a genomic library of the porcine cell line PK15 were isolated. Three identical class A clones, designated PK15-PERV-A(42), PK15-PERV-A(45), and PK15-PERV-A(58), and one class B clone, PK15-PERV-B(213), were characterized. PK15-PERV-B(213) is highly homologous but distinct from the previously described clone PERV-B(43). PK15-PERV-A(58) demonstrates close homology to PERV-A(42) inenv and to PERV-C in long terminal repeat,gag, and pro/polsequences. All three PERV clones described here were replication competent upon infection of susceptible cell lines. The findings suggest that the pig genome harbors a limited number of infectious PERV-A and -B sequences.
The genetics of phenotypic plasticity. XV. Genetic assimilation, the Baldwin effect, and evolutionary rescue

Abstract We used an individual‐based simulation model to examine the role of phenotypic plasticity on persistence and adaptation to two patterns of environmental variation, a single, abrupt step change and continual, linear change. Our model tested the assumptions and predictions of the theory of genetic assimilation, explored the evolutionary dynamics of the Baldwin effect, and provided expectations for the evolutionary response to climate change. We found that genetic assimilation as originally postulated is not likely to occur because the replacement of plasticity by fixed genetic effects takes much longer than the environment is likely to remain stable. On the other hand, trait plasticity as an enhancement to continual evolutionary change may be an important evolutionary mechanism as long as plasticity has little or no costs. Whether or not plasticity helps or hinders evolutionary rescue following a step change in the environment depends on whether plasticity is costly. For linear environmental change, noncostly plasticity always decreases extinction rates, while costly plasticity can create a fitness drag and increase the chance of extinction. Thus, with changing climates plasticity can enhance adaptation and prevent extinction under some conditions, but not others.
Insiders and incomers: how lay public health workers' knowledge might improve public health practice

Since 2005, health trainers and other lay public health workers (LPHWs) have been increasingly active in the UK. Although elsewhere in the world LPHWs are expected to come from the communities within which they work and know that their knowledge is valued, neither is the case for LPHWs in the UK. This study sought to discover the lay knowledge of health trainers and other LPHWs, aiming to ascertain how this knowledge might more effectively be utilised within UK public health services. This paper describes a participatory and ethnographic case study research project undertaken on an anonymised urban estate in North East England. Findings were generated by a range of means including by participant observation and semi-structured interviews. Seven LPHWs took part, as did 32 other community members. This study found that the lay health knowledge of an individual UK LPHW is determined primarily by his or her position within, or in relation to, the community within which he or she works. Insider LPHWs possess an embodied knowledge and incomer LPHWs possess an experiential knowledge which, although different from one another, are essentially interpersonal in nature. Lay health knowledge can take different forms, and different LPHWs can provide different forms of lay health knowledge. Public health structures and services in the UK should make better use of all forms of LPHW knowledge, and should seek from LPHWs training on how to engage the most 'hard-to-reach' or 'difficult-to-engage' groups. Services recruiting LPHWs should decide whether they are seeking embodied insider LPHW knowledge, experiential incomer LPHW knowledge or a mixture of both.
Screening for emphysema via exhaled volatile organic compounds

Chronic obstructive pulmonary disease (COPD)/emphysema risk groups are well defined and screening allows for early identification of disease. The capability of exhaled volatile organic compounds (VOCs) to detect emphysema, as found by computed tomography (CT) in current and former heavy smokers participating in a lung cancer screening trial, was investigated. CT scans, pulmonary function tests and breath sample collections were obtained from 204 subjects. Breath samples were analyzed with a proton-transfer reaction mass spectrometer (PTR-MS) to obtain VOC profiles listed as ions at various mass-to-charge ratios (m/z). Using bootstrapped stepwise forward logistic regression, we identified specific breath profiles as a potential tool for the diagnosis of emphysema, of airflow limitation or gas-exchange impairment. A marker for emphysema was found at m/z 87 (tentatively attributed to 2-methylbutanal). The area under the receiver operating characteristic curve (ROC) of this marker to diagnose emphysema was 0.588 (95% CI 0.453–0.662). Mass-to-charge ratios m/z 52 (most likely chloramine) and m/z 135 (alkyl benzene) were linked to obstructive disease and m/z 122 (most probably alkyl homologs) to an impaired diffusion capacity. ROC areas were 0.646 (95% CI 0.562–0.730) and 0.671 (95% CI 0.524–0.710), respectively. In the screening setting, exhaled VOCs measured by PTR-MS constitute weak markers for emphysema, pulmonary obstruction and impaired diffusion capacity.
Role of channel and floodplain cross‐section geometry in the basin response

We investigate the role of cross‐section geometry in flow routing by developing an analytical framework based on the instantaneous response function (IRF) and relationships of river basin geomorphology. The cross‐section geometry is included explicitly within the framework by assuming a power law cross section that is, in turn, used to derive expressions for the at‐a‐site hydraulic geometry. The analysis performed using the Illinois River basin indicates that the cross‐section geometry takes on different roles depending on whether flows are in the channel or floodplain. The cross‐section geometry where width dominates over depth (width dominant), i.e., the at‐a‐site width‐depth ratio increases with increasing depth, tends to produce a larger network celerity and dispersion for the channel, and the trend reverses for the high floodplain flows. We found that the cross‐section geometry can influence the relative contribution of hydrodynamic and kinematic dispersion. For the channel, the depth‐dominant cross section produces a lower hydrodynamic dispersion than the width‐dominant cross section and vice versa for the floodplain. We found that the nonlinear dependence of the IRF on effective rainfall, expressed in the IRF time to peak and peak flow, may vary depending on the cross‐section geometry, with the nonlinearity decreasing for the width‐dominant cross sections. Additionally, the effect of cross‐section geometry on the basin response can alter the relative contribution of the stream network and hillslopes to the basin dispersion. The derived framework has potential as an a priori tool for incorporating channel and floodplain geometry into distributed rainfall‐runoff models.
The Importance of Testing Multiple Environmental Factors in Legume–Insect Research: Replication, Reviewers, and Rebuttal

Investigating the impacts of predicted changes in our atmosphere and climate change on insect–plant interactions is a widely pursued area of research. To date, the majority of experimental studies have tested the impacts of single environmental factors on insect–plant interactions, but meta-analyses have clearly illustrated the importance of investigating multiple factors in tandem (Zvereva and Kozlov, 2006; Robinson et al., 2012). In particular, environmental change factors often interact with each other which can either strengthen or mitigate the effects of environmental factors acting alone (Robinson et al., 2012). For example, the positive effects of elevated atmospheric carbon dioxide concentrations (e [CO2]) on plant growth are stronger under high nitrogen (N) conditions compared to low N conditions (+ 32 and+ 19%, respectively; Robinson et al., 2012). Likewise, from the limited number of studies available, Robinson et al.(2012) showed that e [CO2] had different impacts on plant nitrogen, plant biomass, and secondary metabolites under elevated air temperature (eT) conditions. This does not invalidate single factor studies, of which we have published numerous examples, but this is an important consideration for making realistic predictions about how plants and insects will respond to future climates (Facey et al., 2014).
BOD, Total and Faecal coliforms bacterial status of Lake Pichhola, Udaipur, Rajasthan

The study has been carried out to investigate the impact of organic loadings on water quality in relation to fish and fisheries of Lake Pichhola. The water quality of Lake Pichhola is highly polluted. The bacterial load of lake water is very high and the values of biological oxygen demand (BOD) show its pollution status. Attempt has been made to relate water quality with the observed waste water discharge in this lake. The overall results from the present investigation indicate that this water body is rapidly under going through process of eutrophication advancement. Therefore, suitable restoration programme should be initiated for the sustained use of this lake, as the lake attracts thousands of tourists from domestic and international level every year.
Bone mineral density, sex hormones, and long-term use of neuroleptic agents in men.

OBJECTIVE To study the prevalence and severity of bone mineral loss and its relationship to sex hormone levels in men on long-term neuroleptic therapy. METHODS Sixteen men with schizophrenia who were from 19 to 62 years old and had taken neuroleptic medication for 1 to 30 years had bone mineral density (BMD) of the lumbar spine and proximal femur measured by dual-energy x-ray absorptiometry. Results were compared with those from 16 age-matched control subjects. Serum testosterone, sex hormone-binding globulin, free testosterone index (FTI), prolactin, and pituitary gonadotropins were assayed and compared with age-matched Red Cross blood donor controls (N = 23 to 90 for the various assays). RESULTS At the lumbar spine and at two of the three sites in the proximal femur (trochanter and Ward's triangle but not femoral neck), the BMD was lower in patients than in controls. A statistically significant increase in prolactin and sex hormone-binding globulin and a significantly decreased luteinizing hormone and FTI were found in the treated versus the control group. In the patient group, a significant inverse relationship existed between age and BMD at all sites. Lumbar spine density was related directly to FTI (r = 0.607; P=0.05) and inversely to duration of treatment (r = -0.767; P<0.001), although both correlations were accounted for mainly by age associations in multiple stepwise linear regression. Prolactin values did not correlate with either BMD or FTI. CONCLUSION BMD was significantly lower with long-term neuroleptic use. In the lumbar spine, these changes may be related to the associated findings of decreased free testosterone and hyperprolactinemia, although the significance of other factors such as an independent drug effect, the psychiatric disease itself, and lifestyle cannot be excluded.