Miracle-dz/UniFAR-FTUs huggingface dataset:
South Africa. A Study in Conflict

The author is a very sophisticated sociologist. He recognizes that no society--and certainly no complex society-is governed by a single determining force and that no complex society can be characterized in terms of any one feature of social structure. South Africa is at one and the same time a highly industrialized and a backward and impoverished rural society (a combination of characteristics which it shares with Italy, for example); like some other societies it is rigidly stratified along the lines of colour but it is also a class structured
Comparable Population Pharmacokinetics and Pharmacodynamic Breakpoints of Cefpirome in Cystic Fibrosis Patients and Healthy Volunteers

ABSTRACT Cystic fibrosis (CF) patients are often reported to have higher clearances and larger volumes of distribution per kilogram of total body weight (WT) for beta-lactams than healthy volunteers. As pharmacokinetic (PK) data on cefpirome from studies of CF patients are lacking, we systematically compared its population PK and pharmacodynamic breakpoints for CF patients and healthy volunteers of similar body size. Twelve adult CF patients (median lean body mass [LBM] = 45.7 kg) and 12 healthy volunteers (LBM = 50.0 kg) received a single 10-min intravenous infusion of 2 g cefpirome. Plasma and urine concentrations were determined by high-performance liquid chromatography (HPLC). Population PK and Monte Carlo simulations were performed using NONMEM and S-ADAPT and a duration of an unbound plasma concentration above the MIC ≥ 65% of the dosing interval as a pharmacodynamic target. Unscaled clearances for CF patients were similar to those seen with healthy volunteers, and the volume of distribution was 6% lower for CF patients. Linear scaling of total clearance by WT resulted in clearance that was 20% higher (P ≤ 0.001 [nonparametric bootstrap]) in CF patients. Allometric scaling by LBM explained the differences between the two subject groups with respect to average clearance and volume of distribution and reduced the unexplained between-subject variability of renal and nonrenal clearance by 10 to 14%. For the CF patients, robust (>90%) probabilities of target attainment (PTA) were achieved by the administration of a standard dose of 2 g/70 kg WT every 12 h (Q12h) given as 30-min infusions for MICs ≤ 1.5 mg/liter. As alternative dosage regimens, a 5-h infusion of 1.33 g/70 kg WT Q8h achieved robust PTAs for MICs ≤ 8 to 12 mg/liter and a continuous infusion of 4 g/day for MICs ≤ 12 mg/liter. Prolonged infusion of cefpirome is expected to be superior to short-term infusions for MICs between 2 and 12 mg/liter.
Faculty Perceptions of Transition Personnel Preparation in Saudi Arabia

This study investigated to what extent faculty members include and value transition curricula in special education preparation programs in Saudi Arabia. A web-based survey was conducted and sent to special education professors across 20 universities. Descriptive statistics and a t-test analysis generated three main findings: (a) Institutions covered transition by adding specialized courses and/or through infusing of transition content in other courses, (b) institutions covered all 29 transition competencies at varying rates, and (c) both male and female faculty members placed high value on teaching their students in the principles of transition education and services. Implications and recommendations for future research were discussed.
The Modern Greek Language: A Descriptive Analysis of Standard Modern Greek

This is the first comprehensive survey of Standard Modern Greek, as it has emerged from the two coexistent varieties of the language - katharevousa and demotic. The book offers a descriptive analysis of the structure of the language and of present-day usage, which is illustrated by examples drawn from a wide cross-section of spoken, written and literary sources.
Screening migrants at risk of tuberculosis.

* The relation between the socioeconomic status of an area and the number ofpsychiatric admissions is well established * Unemployment rates are a useful marker for socioeconomic deprivation * This study found a sevenfold variation between small areas in the rates ofpeople under 65 admitted to psychiatric hospitals * There was a very powerful correlation between the psychiatric admission ratios in those aged under 65 and unemployment rates, explaining over 90% ofthis variation * This should be considered in the process of allocating resources to areas otherwise people with serious mental illness could be considerably disadvantaged
Use of fluorescence resonance energy transfer for rapid detection of isoniazid resistance in Mycobacterium tuberculosis clinical isolates.

SETTING Rapid detection of drug resistance in Mycobacterium tuberculosis is important to select effective treatment and prevent transmission of resistant isolates. OBJECTIVE To evaluate the use of fluorescence resonance energy transfer (FRET) for rapid detection of isoniazid (INH) resistance in M. tuberculosis clinical isolates. DESIGN One hundred INH-resistant and 50 INH-susceptible isolates of M. tuberculosis were included in the study. The drug susceptibility of all isolates was determined by the standard agar proportion method, and all isolates were then tested by FRET. Three genes associated with INH resistance, katG, inhA and ahpC, were analysed. All isolates were amplified with three pairs of primers. Three pairs of fluorescently labelled DNA probes specific to codon 315 of katG, nucleotide 209 in the regulatory region of inhA and a frequent mutation site in the intergenic region of oxyR-ahpC, were used for mutation detection. RESULTS The results obtained using FRET were compared with those from the proportion method. The sensitivity and specificity of FRET were respectively 76% and 100%. The frequencies of mutations were 48% in katG, 17% in inhA, 8% in ahpC, 2% in inhA-ahpC and 1% in inhA-katG. CONCLUSION FRET is a rapid, specific method that can be useful to detect INH resistance in M. tuberculosis clinical isolates.
Nuclear Hormone Receptor NHR-49 Controls Fat Consumption and Fatty Acid Composition in C. elegans

Mammalian nuclear hormone receptors (NHRs), such as liver X receptor, farnesoid X receptor, and peroxisome proliferator-activated receptors (PPARs), precisely control energy metabolism. Consequently, these receptors are important targets for the treatment of metabolic diseases, including diabetes and obesity. A thorough understanding of NHR fat regulatory networks has been limited, however, by a lack of genetically tractable experimental systems. Here we show that deletion of the Caenorhabditis elegans NHR gene nhr-49 yielded worms with elevated fat content and shortened life span. Employing a quantitative RT-PCR screen, we found that nhr-49 influenced the expression of 13 genes involved in energy metabolism. Indeed, nhr-49 served as a key regulator of fat usage, modulating pathways that control the consumption of fat and maintain a normal balance of fatty acid saturation. We found that the two phenotypes of the nhr-49 knockout were linked to distinct pathways and were separable: The high-fat phenotype was due to reduced expression of enzymes in fatty acid β-oxidation, and the shortened adult life span resulted from impaired expression of a stearoyl-CoA desaturase. Despite its sequence relationship with the mammalian hepatocyte nuclear factor 4 receptor, the biological activities of nhr-49 were most similar to those of the mammalian PPARs, implying an evolutionarily conserved role for NHRs in modulating fat consumption and composition. Our findings in C. elegans provide novel insights into how NHR regulatory networks are coordinated to govern fat metabolism.
The prognostic significance of vascular invasion by endometrial carcinoma.

BACKGROUND Recently, invasion of vascular spaces by endometrial carcinoma has received particular attention as a prognostic factor. The goal of the current investigation was to re-examine the effect of vascular invasion on tumor recurrence and survival in patients with endometrial carcinoma. METHODS Surgical specimens from 238 patients with endometrial carcinoma were examined for the presence of vascular invasion by tumor cells. Vascular invasion was compared with clinicopathologic features and postoperative survival. Survival curves by vascular invasion were evaluated by the Kaplan-Meier method. RESULTS In a histopathologic review of 238 cases of endometrial carcinoma, 82 neoplasms demonstrated vascular invasion. Vascular invasion significantly correlated with the extension of primary tumor, depth of myometrial invasion, and histologic grade. Patients with lymph node metastasis had a significantly higher incidence of vascular invasion. Survival at 5 years for patients with vascular invasion was 73.4%. This was significantly lower than the survival rate of 91.5% for women without this finding (P < 0.001). Among patients with lymph node metastasis, 80.2% of the patients with vascular invasion survived for 5 years compared with 95.3% of the patients without vascular invasion (P < 0.05). Ten of 47 patients with no lymph node metastasis but with vascular invasion developed recurrent carcinoma. Nine of these ten patients apparently had extrapelvic recurrences. CONCLUSIONS The presence of vascular invasion is a reliable prognostic indicator. Recording of tumor recurrence pattern may lead to a better selection of patients for adjuvant systemic therapy after surgery.
Midlife cardiovascular risk factors, ApoE, and cognitive decline in elderly male twins

Objective To investigate the combined effect of the apolipoprotein E 4 (ApoE'4) allele and midlife cardiovascular risk factors on cognitive decline. Methods Data are from the National Heart, Lung, and Blood Institute Twin Study-a longitudinal cardiovascular epidemiologic study of World War I1 male veteran twins currently in its 27th year of follow-up. Subjects were assessed for cardiovascular risk factors, including BP and glucose levels, at mean ages 48, 58, and 63 years. Participants in the current study are 410 individual twin subjects for whom cognitive function was measured twice, at ages 63 and 73 years. Ten-year change scores in performance on neuropsychological test examinations were adjusted for age, education, baseline score, and incident cardiovascular disease. Results For the sample as a whole, we observed a significant decline (p < 0.01) in cognitive performance over the 10 years of follow-up. ApoE'4 carriers with midlife hyperglycemia experienced the greatest decline in performance, which was also greater than expected from the separate effects combined. Midlife hypertension and ApoE'4, were each associated with excess decline in performance on tests of psychomotor speed. Their joint effect, however, was not greater than expected from the separate effects combined. Conclusions ApoE'4 and midlife cardiovascular risk factors may have a synergistic effect on decline in cognitive function. This effect may be due to greater vascular or degenerative damage among subjects with ApoE'4. NEUROLOGY 1998;50:1580–1585
[Changing social disparities and mortality in France (1968-1996): cause of death analysis by educational level].

BACKGROUND Little information is available on temporal trend in socioeconomic inequalities in cause of death mortality in France. The aim of this paper was to study educational differences in mortality in France by cause of death and their temporal trend. METHODS We used a representative sample of 1% of the French population and compared four periods (1968-1974, 1975-1981, 1982-1988, 1990-1996). Causes of death were obtained by direct linkage with the French national death registry. Education was measured at the beginning of each period, and educational disparities in mortality were studied among men and women aged 30-64 at the beginning of each period. Analyses were conducted for all deaths and for the following causes of death: all cancers, lung cancer (among men), upper aerodigestive tract cancers (among men), breast cancer (among women), colorectal cancer, other cancers, cardiovascular diseases, ischaemic heart diseases, cerebrovascular diseases, other cardiovascular diseases, external causes, other causes of death. Socioeconomic inequalities were quantified with relative risks and relative indices of inequality. The relative indices of inequality measures socioeconomic inequalities across the population and can be interpreted as the ratio of mortality rates of those with the lowest to those with the highest socioeconomic status. RESULTS Analyses showed an increase in educational differences in all cause mortality among men (the relative indices of inequality increased from 1.96 to 2.77 from the first to the last period) and among women (the relative indices of inequality increased from 1.87 to 2.53). Socioeconomic inequalities increased for all cause of death studied among women, and for cancer and cardiovascular diseases among men. The contribution of cancer mortality to difference in overall mortality between the lowest and the highest levels of education increased strongly over the whole study period, especially among women. CONCLUSION This study shows that large socioeconomic inequalities in mortality are observed in France, and that they increase over time among men and women.
Dolasetron for the prevention of postoperative vomiting in children undergoing strabismus surgery

Background: Children undergoing strabismus surgery have a high incidence of postoperative vomiting (POV). The purpose of this study was to assess the efficacy and safety of dolasetron for the prevention of emesis comparing a single 0.35 mg·kg−1 or 12.5 mg dose with placebo.
Psychological sources of response effects in self-administered and telephone surveys

The impact of mode of data collection (self-administered questionnaire vs. telephone interview) on the emergence of response effects and the accuracy of recall from memory was explored in a cross-cultural experiment, conducted in the U.S. and the Federal Republic of Germany. As predicted on the basis of psychological considerations, question order effects were obtained under telephone interview conditions but not under self­ administered conditions, where question order is eliminated by the opportunity to browse back and forth through the questionnaire. On the other hand, the impact of the content of related questions was more pronounced under self-administered than under telephone interview conditions, independent of the order in which they were presented. This reflects respondents' differential opportunity to elaborate on related questions under both administration modes, as well as the necessity to rely on the content of presumably related questions in determining the meaning of ambiguous questions under self-administered conditions. Finally, respondents' recall of the date of public events was more accurate under self-administered than under telephone interview conditions, reflecting the beneficial effect of having sufficient time to work on the recall task.
Iodine status and associations with feeding practices and psychomotor milestone development in six-month-old South African infants.

Iodine is important for normal growth and psychomotor development. While infants below 6 months of age receive iodine from breast milk or fortified infant formula, the introduction of complementary foods poses a serious risk for deteriorating iodine status. This cross-sectional analysis assessed the iodine status of six-month-old South African infants and explored its associations with feeding practices and psychomotor milestone development. Iodine concentrations were measured in infant (n = 386) and maternal (n = 371) urine (urinary iodine concentration [UIC]), and in breast milk (n = 257 [breast milk iodine concentrations]). Feeding practices and psychomotor milestone development were assessed in all infants. The median (25th-75th percentile) UIC in infants was 345 (213-596) μg/L and was significantly lower in stunted (302 [195-504] μg/L) than non-stunted (366 [225-641] μg/L) infants. Only 6.7% of infants were deficient. Maternal UIC (128 [81-216] μg/L; rs = 0.218, p < 0.001) and breast milk iodine concentrations (170 [110-270] μg/kg; rs = 0.447, p < 0.0001) were associated with infant UIC. Most infants (72%) were breastfed and tended to have higher UIC than non-breastfed infants (p = 0.074). Almost all infants (95%) consumed semi-solid or solid foods, with commercial infant cereals (60%) and jarred infant foods (20%) being the most common solid foods first introduced. Infants who reported to consume commercial infant cereals ≥4 days weekly had significantly higher UIC (372 [225-637] μg/L) than those reported to consume commercial infant cereals seldom or never (308 [200-517] μg/L; p = 0.023). No associations between infant UIC and psychomotor developmental scores were observed. Our results suggest that iodine intake in the studied six-month-old infants was adequate. Iodine in breast milk and commercial infant cereals potentially contributed to this adequate intake.
Inoculating Against a Losing Season: Can Inoculation-Informed Public Relations Strategies Protect Fan Loyalty?

Inoculation theory is a classic theory of resistance to influence, modeling a way to confer resistance to challenges based on biological inoculation processes. This commentary explores inoculation’s efficacy in the applied context of sport communication, with special consideration of how inoculation may guide sportmarketing strategies to preemptively bolster existing support for a team in the face of challenges (e.g., a losing season).
Studies on the urinary excretion of xanthurenic acid in diabetics.

Xanthurenic acid (XA), kynurenic acid (KA) and creatinine in fasting urine were determined by reversed phase high pressure liquid chromatography in order to investigate the distortion of tryptophan metabolites in diabetes mellitus. The results of ten patients with non-insulin dependent diabetes mellitus and ten normal healthy subjects were compared. No tryptophan load test was performed in this study, because tryptophan loading produces further latent shortage of active vitamin B6 which results in exacerbation of the disease. The ratios of XA to KA and to creatinine were 0.35 +/- 0.099 (mean +/- S.D.) and 0.99 +/- 0.321 in the diabetic patients. The corresponding figures in the normal subjects were 0.17 +/- 0.064 and 0.55 +/- 0.22. Both ratios were significantly higher in the diabetic patients than in normal subjects (p less than 0.001 and p less than 0.01, respectively). This means that XA was excessively excreted in diabetic patients resulting in distortion of tryptophan metabolism. Our findings indicated that the ratios are useful to monitor excess XA excretion and also for detection of diabetes.
Adult input and children's acquisition of Creole syntax

This book examines the acquisition of syntax in Seselwa and Morisyen children. Seselwa and Morisyen are historically related creoles spoken in the Seychelles and Mauritius, respectively. Working within Chomsky's (1981) framework, Adone focuses on the acquisition of (non-)reflexive pronouns, double object constructions (DOCs), passive and serial verb constructions (SVCs).
Rape culture and social media: young critics and a feminist counterpublic

Abstract Social media sites, according to Carrie A. Rentschler, can become both “aggregators of online misogyny” as well as key spaces for feminist education and activism. They are spaces where “rape culture,” in particular, is both performed and resisted, and where a feminist counterpublic can be formed (Michael Salter 2013). In this New Zealand study, we interviewed seventeen young people who were critical of rape culture about their exposure and responses to it on social media and beyond. Participants described a “matrix of sexism” in which elements of rape culture formed a taken-for-granted backdrop to their everyday lives. They readily discussed examples they had witnessed, including victim-blaming, “slut-shaming,” rape jokes, the celebration of male sexual conquest, and demeaning sexualized representations of women. While participants described this material as distressing, they also described how online spaces offered inspiration, education, and solidarity that legitimated their discomfort with rape culture. Social media provided safe spaces that served as a buffer against the negative effects of sexism, and allowed participation in a feminist counterpublic that directly contests rape culture.
Expert youth coaches’ diversification strategies in talent development: A qualitative typology

The development of expert-level performance in sports is discussed against the background of two different pathways. The early specialization approach emphasizes both early onset and high volumes of sport-specific practice in a desired main sport. On the other hand, the diversification approach promotes diversified involvement in a range of other sports with later specialization. This study examines the way in which youth coaches translate the antagonistic concepts of specialization and diversification into their coaching strategies during the early stages of talent development. Using qualitative research methodology, 44 expert German youth coaches (M age = 45.1 years, SD = 7.5; 39 male and 5 female) in 24 different sports, with an average of 21.7 years accumulated coaching experience (SD = 7.0) were included in the inductive thematic analysis. Analysis showed a differentiated understanding of the process of specialization that considered multiple ways to apply diversification both within sports and across several sports. Although all of the coaches appeared to acknowledge the importance of within-sports diversification, there was considerable variation in the reported purposeful implementation and significance of sporting activities other than the main sport leading to a nuanced typology of strategies. The typology could be divided into the following four categories based on the preferred strategies that the coaches described: (I) changers and late entrants; (II) early engagement in DS + secondary sports; (III) early engagement in DS + supplementary sports; and (IV) early engagement in DS + specialization. The findings strengthened existing suggestions of a gradual and multidimensional understanding of diversification prior to necessary specialization. Furthermore, it can be assumed that the preferred strategies are fundamentally influenced by individual cognitions and contextual aspects that acknowledge the complex and ideographical nature of coaching.
Markets for Inventors: Learning-by-Hiring as a Driver of Mobility

Hiring away inventors has long been recognized as a way of learning used by innovative firms. This paper claims that the characteristics of the knowledge accumulated by an inventor at his current employer affect what hiring firms can learn from him. The implication is that some inventors are more likely to be hired away than their coworkers. We analyze the relationship between the type of knowledge embodied by inventors working at IBM and their probability of moving. Relying on patent data to track the movement of inventors across firms and to characterize the kind of know-how they hold, we identify the following drivers of inventor mobility: the quality of their work; the complementarity of their knowledge with that of other inventors; and, to a lower extent, their expertise in the firm's core areas in which the firm is not a dominant player. Results confirm the role of knowledge characteristics behind the mobility of research and development personnel and suggest that learning is a relevant force in the market for inventors.