Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of the seroprevalence of bovine paratuberculosis and the application of modified absorbed ELISA to field sample testing in Korea

Paratuberculosis (PTB) is a major disease problem worldwide, and causes major economic losses in the dairy industry. Although PTB has been reported in Korea, no studies have been conducted to determine its prevalence and no program has been developed to control the disease. In this study, the sera of beef (n = 1,056) and dairy cattle (n = 1,105) from all provinces in Korea were tested to determine the prevalence of PTB using two different ELISA: an 'in house' modified absorbed ELISA (P-ELISA) based on sonicated antigen from Mycobacterium avium subsp. paratuberculosis ATCC 19698, and a commercial ELISA (C-ELISA). Receiver operating characteristic analysis was used to determine the cutoff point for P-ELISA. Based on C-ELISA results, the area under the curve for P-ELISA was 0.913 (95% CI, 0.883 to 0.943). Using a cutoff point of 0.100, P-ELISA showed a sensitivity of 62.0% and a specificity of 93.7%. The kappa value and the percent agreement between the two ELISAs were 0.322 and 92.5%, respectively. Both ELISAs showed a significant correlation between age and seropositivity (p < 0.01). According to C-ELISA, 71 of 2,161 sera (3.3%, 95 CI, 2.6% to 4.1%) were test-positive. The national true prevalence of PTB was estimated to be 7.1%. The findings suggest that a control program should be implemented to limit the spread of this disease, and that P-ELISA could be used as a screening test that produces results similar to C-ELISA.
Why Has Regional Convergence in the U.S. Stopped

The past thirty years have seen a dramatic decrease in the rate of income convergence across U.S. states. This decline coincides with a similarly substantial decrease in population flows to wealthy states. We develop a model where labor mobility plays a central role in convergence and can quantitatively account for its disappearance. We then link this decline in directional migration to a large increase in housing prices and housing regulation in high-income areas. The model predicts that these housing market changes generate (1) a divergence in the skill-specific economic returns to living in rich places, (2) a decline in low-skilled migration to rich places and continued low-skilled migration to places with high income net of housing costs, (3) a decline in the rate of human capital convergence and (4) continued income convergence among places with unconstrained housing supply. Using Census data, we find support for the first three hypotheses. To test the fourth hypothesis, we develop a new state-level panel measure of housing supply regulations. Using this measure as an instrument for housing prices, we document the central role of housing prices and building restrictions in the end of income convergence.
Dab1 (Disable Homolog-1) Reelin Adaptor Protein Is Overexpressed in the Olfactory Bulb at Early Postnatal Stages

Dab1 mediates reelin signalling and plays critical roles in early brain development such as the stereotypical positioning of neurons in the brain. The olfactory bulb undergoes a prominent layering reorganization, but shows not apparent differences between wild type and reeler in the layer organization. Therefore, an accurate regional and cellular simultaneous analysis of these molecules becomes essential to clarify the role played by Dab1 upon Reelin effect. The present study reveals a strong and consistent Dab1 mRNA and protein expressions, throughout the olfactory bulb layers in both wild type and reeler mice. In addition, noteworthy is the pattern of Dab1 location within cell nuclei in both strains. Furthermore, a temporal increment of Dab1 expression levels is detected from P0 to P15 in both strains, being the protein quantity higher in reeler than in wild type mice. Altogether, our results revealed that Reln acts directly from projection neurons via the production of different Reln fragments. Changes in the pattern of Dab1 expression could reflect an alternative Reln function in postnatal and adult stages, besides a possible regulation of Dab1 by other molecules distinct to Reln.
Canadian Physicians' Use of Antiobesity Drugs and Their Referral Patterns to Weight Management Programs or Providers: The SOCCER Study

Antiobesity pharmacotherapy and programs/providers that possess weight management expertise are not commonly used by physicians. The underlying reasons for this are not known. We performed a cross-sectional study in 33 Canadian medical practices (36 physicians) examining 1788 overweight/obese adult patients. The frequency of pharmacotherapy use and referral for further diet, exercise, behavioral management and/or bariatric surgery was documented. If drug treatment or referral was not made, reasons were documented by choosing amongst preselected categories. Logistic regression models were used to identify predictors of antiobesity drug use. No single antiobesity management strategy was recommended by physicians in more than 50% of patients. Referral was most common for exercise (49% of cases) followed by dietary advice (46%), and only 5% of eligible patients were referred for bariatric surgery. Significant predictors of initiating/continuing pharmacotherapy were male sex (OR 0.70; 95% CI 0.52–0.94), increasing BMI (1.02; 95% CI 1.01–1.03), and private drug coverage (1.78; 95% CI 1.39–2.29). “Not considered” and “patient refusal” were the main reasons for not initiating further weight management. We conclude that both physician and patient factors act as barriers to the use of weight management strategies and both need to be addressed to increase uptake of these interventions.
A Randomised Controlled Trial to Delay or Prevent Type 2 Diabetes after Gestational Diabetes: Walking for Exercise and Nutrition to Prevent Diabetes for You

Aims. To develop a program to support behaviour changes for women with a history of Gestational Diabetes Mellitus (GDM) and a Body Mass Index (BMI) > 25 kg/m2 to delay or prevent Type 2 Diabetes Mellitus. Methods. Women diagnosed with GDM in the previous 6 to 24 months and BMI > 25 kg/m2 were randomized to an intervention (I) (n = 16) or a control (C) (n = 15) group. The intervention was a pedometer program combined with nutrition coaching, with the primary outcome increased weight loss in the intervention group. Secondary outcomes included decreased waist and hip measurements, improved insulin sensitivity and body composition, increased physical activity, and improved self-efficacy in eating behaviours. Results. Median (IQR) results were as follows: weight: I −2.5 (2.3) kg versus C +0.2 (1.6) kg (P = 0.009), waist: I −3.6 (4.5) cm versus C −0.1 (3.6) cm (P = 0.07), and hip: I −5.0 (3.3) cm versus C −0.2 (2.6) cm (P = 0.002). There was clinical improvement in physical activity and eating behaviours and no significant changes in glucose metabolism or body composition. Conclusion. A pedometer program and nutrition coaching proved effective in supporting weight loss, waist circumference, physical activity, and eating behaviours in women with previous GDM.
Building the Family Nest : Pre-Marital Investments , Marriage Markets and Spousal Allocations

Building the Family Nest: Pre-Marital Investments, Marriage Markets and Spousal Allocations We develop a model of the household in which spousal incomes are determined by premarital investments, the marriage market is characterized by assortative matching, and endogenously-determined sharing rules form the basis of intra-household allocations. By incorporating pre-marital investments and spousal matching into the collective household model, we are able to identify the fundamental determinants of endogenously determined and maritally sustainable intra-marital sharing rules. In particular, we find that all sharing rules along the assortative order support unconditionally efficient outcomes where both pre-marital investments and intra-household allocations are efficient. The efficiency of both pre-marital choices and household allocations then enables us to show that, for each couple, the marriage market generates a unique and maritally sustainable sharing rule that is a function of the distribution of pre-marital endowments and the sex ratios in the market. JEL Classification: C78, D61, D70
On Optimal Frequency-Domain Multichannel Linear Filtering for Noise Reduction

Several contributions have been made so far to develop optimal multichannel linear filtering approaches and show their ability to reduce the acoustic noise. However, there has not been a clear unifying theoretical analysis of their performance in terms of both noise reduction and speech distortion. To fill this gap, we analyze the frequency-domain (non-causal) multichannel linear filtering for noise reduction in this paper. For completeness, we consider the noise reduction constrained optimization problem that leads to the parameterized multichannel non-causal Wiener filter (PMWF). Our contribution is fivefold. First, we formally show that the minimum variance distortionless response (MVDR) filter is a particular case of the PMWF by properly formulating the constrained optimization problem of noise reduction. Second, we propose new simplified expressions for the PMWF, the MVDR, and the generalized sidelobe canceller (GSC) that depend on the signals' statistics only. In contrast to earlier works, these expressions are explicitly independent of the channel transfer function ratios. Third, we quantify the theoretical gains and losses in terms of speech distortion and noise reduction when using the PWMF by establishing new simplified closed-form expressions for three performance measures, namely, the signal distortion index, the noise reduction factor (originally proposed in the paper titled ldquoNew insights into the noise reduction Wiener filter,rdquo by J. Chen (IEEE Transactions on Audio, Speech, and Language Processing, Vol. 15, no. 4, pp. 1218-1234, Jul. 2006) to analyze the single channel time-domain Wiener filter), and the output signal-to-noise ratio (SNR). Fourth, we analyze the effects of coherent and incoherent noise in addition to the benefits of utilizing multiple microphones. Fifth, we propose a new proof for the a posteriori SNR improvement achieved by the PMWF. Finally, we provide some simulations results to corroborate the findings of this work.
Application of time-reversal with MMSE equalizer to UWB communications

We propose to apply a technique called time-reversal to UWB communications. In time-reversal a signal is precoded such that it focuses both in time and in space at a particular receiver. Spatial focusing reduces interference to other co-existing systems. Due to temporal focusing, the received power is concentrated within a few taps and the task of equalizer design becomes much simpler than without focusing. Furthermore, temporal focusing allows a large increase in transmission rate compared to schemes that let the impulse response ring out before the next symbol is sent. Our paper introduces time-reversal, investigates the benefit of temporal focusing, and examines the performance of an MMSE-TR equalizer in an UWB channel.
The anti-inflammatory mechanisms of Hsp70

Immune responses to heat shock proteins (Hsp) develop in virtually all inflammatory diseases; however, the significance of such responses is only now becoming clear. In experimental disease models, Hsp administration can prevent or arrest inflammatory damage, and in initial clinical trials in patients with chronic inflammatory diseases, Hsp peptides have been shown to promote the production of anti-inflammatory cytokines, indicating immunoregulatory potential of Hsp. Therefore, the presence of immune responses to Hsp in inflammatory diseases can be seen as an attempt of the immune system to correct the inflammatory condition. Hsp70 can modulate inflammatory responses in models of arthritis, colitis and graft rejection, and the mechanisms underlying this effect are now being elucidated. Incubation with microbial Hsp70 was seen to induce tolerogenic dendritic cells (DCs) and to promote a suppressive phenotype in myeloid-derived suppressor cells and monocytes. These DC could induce regulatory T cells (Tregs), independently of the antigens they presented. Some Hsp70 family members are associated with autophagy, leading to a preferential uploading of Hsp70 peptides in MHC class II molecules of stressed cells. Henceforth, conserved Hsp70 peptides may be presented in these situations and constitute targets of Tregs, contributing to downregulation of inflammation. Finally, an interfering effect in multiple intracellular inflammatory signaling pathways is also known for Hsp70. Altogether it seems attractive to use Hsp70, or its derivative peptides, for modulation of inflammation. This is a physiological immunotherapy approach, without the immediate necessity of defining disease-specific auto-antigens. In this article, we present the evidence on anti-inflammatory effects of Hsp70 and discuss the need for experiments that will be crucial for the further exploration of the immunosuppressive potential of this protein.
Fundamental Human Motive Self-Enhancement and Self-Protection Strategies in China : Cultural Expressions of a

The motive to enhance and protect positive views of the self manifests in a variety of cognitive and behavioral strategies, but its universality versus cultural specificity is debated by scholars. We sought to inform this debate by soliciting self-reports of the four principal types of selfenhancement and self-protection strategy (positivity embracement, favorable construals, selfaffirming reflections, defensiveness) from a Chinese sample and comparing their structure, levels, and correlates to a Western sample. The Chinese data fit the same factor structure and were subject to the same individual differences in regulatory focus, self-esteem, and narcissism, as the Western data. Chinese participants reported lower levels of (enhancement-oriented) positivity embracement but higher levels of (protection-oriented) defensiveness than Western participants. Levels of favorable construals were also higher in the Chinese sample, with no differences in self-affirming reflections. These findings support and extend the universalist perspective on the self by demonstrating the cross-cultural structure, yet culturally sensitive manifestation, of self-enhancement motivation.
Structure and Function in the Lexical System: Insights from Distributed Models of Word Reading and Lexical Decision

The traditional view of the lexical system stipulates word-specific representations and separate pathways for regular and exception words. An alternative approach views lexical knowledge as developing from general learning principles applied to mappings among distributed representations of written and spoken words and their meanings. On this distributed account, distinctions among words, and between words and nonwords, are not reified in the structure of the system but reflect the sensitivity of learning to the relative systematicity in the various mappings. Two computational simulations address findings that have seemed problematic for the distributed approach. Both involve a consideration of the role of semantics in normal and impaired lexical processing. The first simulation accounts for patients with impaired comprehension but intact reading in terms of individual differences in the division of labour between the semantic and phonological pathways. The second simulation demonstrates that a distributed.
Emerging Adolescence in Engaged Reading Communities

This article examines what students do when they are engaged in reading stories that resonate with them. The narratives that draw them in often contain topics and language that make adults nervous, particularly at this age. Students use these books and the characters within them as tools for self-reflection, as cautionary tales, as ways to understand other people better, and to develop empathy. We provide instructional implications related to a wide range of texts and teacher talk that invites productive conversations. This article can be used as a resource for teachers and, by extension, parents who are unsure or apprehensive about what students might do with texts and conversations in which they are exploring new social worlds and identities that are beginning to evolve from childhood into adolescence.
Inference on a Generalized Roy Model, with an Application to Schooling Decisions in France

This paper considers the identification and estimation of an extension of Roy's model (1951) of occupational choice, which includes a non-pecuniary component in the decision equation and allows for uncertainty on the potential outcomes. This framework is well suited to various economic contexts, including educational and sectoral choices, or migration decisions. We focus in particular on the identification of the non-pecuniary component under the condition that at least one variable affects the selection probability only through potential earnings, that is under the opposite of the usual exclusion restrictions used to identify switching regressions models and treatment effects. Point identification is achieved if such variables are continuous, while bounds are obtained otherwise. As a result, the distribution of the ex ante treatment effects can be point or set identified without any usual instruments. We propose a three-stages semiparametric estimation procedure for this model, which yields root-n consistent and asymptotically normal estimators. We apply our results to the educational context, by providing new evidence from French data that non-pecuniary factors are a key determinant of higher education attendance decisions.
Barriers to Middle-Aged Women’s Mental Health: A Qualitative Study

Background: Middle-aged women encounter some barriers to their mental health, putting them at great risk for developing mental disorders. Objectives: The aim of this study was to explore barriers to middle-aged women’s mental health. Materials and Methods: This was a qualitative content analysis study conducted in 2013 in Kashan, Iran. A purposive, maximum variation sample of 23 middle-aged women was recruited to the study. Data were collected by conducting semi-structured individual interviews. We employed the conventional qualitative content analysis approach for data analysis. Results: Barriers to middle-aged women’s mental health fell into two main themes including ‘increased life concerns’ and ‘physical and psychological tensions’. The two sub-categories of the first theme included having mental concerns and increased burden of roles. The second main theme also consisted of two categories including perceived undesirable physical changes and perceived undesirable psychological changes. Conclusions: Experiences of middle-aged women showed that culturally appropriate interventions to alleviate the concerns of life, physical and mental stress is essential to preserve stability of mental health.
Using knowledge elicitation to improve Web effort estimation: Lessons from six industrial case studies

This paper details our experience building and validating six different expert-based Web effort estimation models for ICT companies in New Zealand and Brazil. All models were created using Bayesian networks, via eliciting knowledge from domain experts, and validated using data from past finished projects. Post-mortem interviews with the participating companies showed that they found the entire process extremely beneficial and worthwhile, and that all the models created remained in use by those companies.
The Role of Glutamine Oxoglutarate Aminotransferase and Glutamate Dehydrogenase in Nitrogen Metabolism in Mycobacterium bovis BCG

Recent evidence suggests that the regulation of intracellular glutamate levels could play an important role in the ability of pathogenic slow-growing mycobacteria to grow in vivo. However, little is known about the in vitro requirement for the enzymes which catalyse glutamate production and degradation in the slow-growing mycobacteria, namely; glutamine oxoglutarate aminotransferase (GOGAT) and glutamate dehydrogenase (GDH), respectively. We report that allelic replacement of the Mycobacterium bovis BCG gltBD-operon encoding for the large (gltB) and small (gltD) subunits of GOGAT with a hygromycin resistance cassette resulted in glutamate auxotrophy and that deletion of the GDH encoding-gene (gdh) led to a marked growth deficiency in the presence of L-glutamate as a sole nitrogen source as well as reduction in growth when cultured in an excess of L-asparagine.
Identifying professional functionings of early childhood educators

Abstract What does being a professional early childhood educator entail? This paper aims to address this question. Starting from the early 2000s, there has been increased attention to workforce professionalization in the early childhood education and care sector across OECD nations. Against the backdrop of recent early childhood workforce professionalization initiatives in Australia, and drawing on the Capability Approach to human development as an analytical framework, in this paper, we identify five evaluative spaces for assessing professional functionings: expertise, deliberation, recognition, responsiveness and integrity. We also argue that understanding what educators are actually able to be and do in their professional practices vis-à-vis policy expectations is instrumental in (a) identifying areas of professional learning needs, and (b) devising transformative learning experiences.
Serum levels of vascular endothelial growth factor in chronic obstructive pulmonary disease

Background: Chronic obstructive pulmonary disease (COPD) is a third leading cause of death. Methods: In this case control study, we prepared 5 cc bloods from the antecubital vein of 100 COPD patients and 40 healthy individuals as control group. Vascular endothelial growth factor (VEGF) expression protein level was measured by ELISA in both groups. Results: We found that concentration of VEGF in blood serum of patients with COPD (189.9±16pg/ml) was significantly higher than the control group (16.4±3.48pg/ml) (p<0.001). While VEGF serum level in emphysematous patients wasn’t significantly different with control group (p=0.07). Furthermore VEGF serum level in COPD patients was proportionally increased with severity of disease (p<0.001). Besides all COPD patients, regardless of their smoking status, were experienced significantly higher levels of VEGF than healthy ones (p=0.001; z=4.3). Conclusion: Our results suggest VEGF serum concentration as the sensitive index for severity and activity of COPD and its prognosis.