Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship between nocturnal hypoxaemia, tachycardia and myocardial ischaemia after major abdominal surgery.

BACKGROUND Episodic hypoxaemia, cardiac arrhythmias, and myocardial ischaemia may be related after major abdominal surgery. METHODS We studied 52 patients on the second and third nights after major abdominal operations, using continuous pulse oximetry and Holter ECG. We recorded the amount of time spent with oxygen saturation values less than 90, 85, and 80% during the night, and noted episodes of hypoxaemia, tachycardia, bradycardia, and ST-segment changes. RESULTS In 87 study nights there were 2403 (individual range 1-229) episodes of hypoxaemia, 3509 (individual range 1-234) episodes of tachycardia, and 265 (individual range 1-73) episodes of ST segment deviation. Of the 52 patients, 50 had episodes of hypoxaemia and tachycardia, and 19 patients had one or more episodes of ST segment deviation. For 38% of the episodes of ST deviation, there was an episode of hypoxaemia at the same time and in 16% there was an episode of tachycardia. ST deviation was only noted in 4% of the episodes of hypoxaemia and in 1% of the episodes of tachycardia. CONCLUSION Episodes of hypoxaemia and tachycardia frequently occur together after surgery but are rarely associated with ST deviation. Hypoxaemia or tachycardia is often present at the same time as ST deviation occurs.
Genetic variation of XPA gene and risk of cancer: A systematic review and pooled analysis

XPA, a zinc‐finger DNA‐binding protein, play an important role in both global genome and transcription‐coupled repair pathways. XPA −4G>A polymorphism was identified in the 5′ noncoding region, located four nucleotides upstream of the ATG start codon. Previous studies have shown that this polymorphism may affect mRNA tertiary structure and stability and play a role in susceptibility to cancer. However, the results remained controversial. To derive a more precise estimation of association between this polymorphism and risk of different types of cancer, we performed a meta‐analysis based on 36 case–control or case–cohort studies, including a total of 11,700 cases and 15,033 controls. We used odds ratios with 95% confidence intervals to assess the strength of the association. Overall, no significantly elevated cancer risk was found in all genetic models when eligible studies were pooled into the meta‐analysis. In the stratified analyses, we found that individuals with A‐allele had a higher risk of lung cancer (AA versus GG: OR = 1.25, 95% CI = 1.09–1.43; recessive model: OR = 1.31, 95% CI = 1.16–1.48). When stratified by ethnicity, significantly elevated risks were observed among Asian populations (AA versus GG: OR = 1.31, 95% CI = 1.01–1.70; dominant model: OR = 1.14, 95% CI = 1.00–1.30). This meta‐analysis suggests that XPA −4G>A polymorphism is associated with increased lung cancer risk and may be a low‐penetrant risk factor in Asian ethnicity for cancer development.
Twenty-five years on – from cultural studies to intercultural citizenship

At the editor's invitation this article was written as an analysis of the development of the intercultural dimension of foreign language teaching over the last 25 years. It is in part a personal reflection based on an article written for this journal 25 years ago, but it also draws on comments and insights from a network of researchers with whom the author has worked over much of the period in question. Four areas are selected for comment: ‘the value of cultural studies’, ‘pedagogy and didactics’, ‘methodology’ and ‘assessment and evaluation’. It is argued that in the intervening period, the value of a cultural or intercultural dimension in language teaching has been widely recognised in policy documents and approaches to pedagogy developed. The picture with respect to methods of teaching for intercultural competence is mixed and the question of assessment remains insufficiently developed. Looking forward, the conclusion is that the most important area for development is in teacher education. There is still a lack of understanding among teachers with respect to the significance of intercultural competence and its relationship to linguistic competence.
Prediction of Protein Secondary Structure with two-stage multi-class SVMs

Bioinformatics techniques to Protein Secondary Structure (PSS) prediction mostly depend on the information available in amino acid sequences. In this paper, we propose a two-stage Multi-class Support Vector Machine (MSVM) approach, where the second MSVM predictor is introduced at the output of the first stage MSVM to capture the contextual relationship among secondary structure elements in order to minimise the generalisation error in the prediction. By using position-specific scoring matrices generated by PSI-BLAST, the two-stage MSVM approach achieves Q3 accuracies of 78.0% and 76.3% on the RS126 dataset of 126 non-homologous globular proteins and the CB396 dataset of 396 non-homologous proteins, respectively, which are better than the scores reported on both datasets to date. By using MSVM, the present prediction scheme significantly achieves 2-6% and 3-15% of improvement in Q3 and Sov accuracies, respectively, on the two datasets. On larger blind-test datasets from PSIPRED, CASP4 and EVA datasets, two-stage MSVM approach achieves Q3 accuracies from 77.0% to 79.5%.
THE DEVELOPMENT OF A SELF‐ESTEEM QUESTIONNAIRE

Summary. The questionnaire (LAWSEQ) was constructed to measure self-esteem in primary school children. The questions were selected to cover the main areas of concern shown by children in an earlier counselling study. There were 20 questions in the original version, including four innocuous ones, and with a parallel form (Form B). In the final version the questionnaire comprises 16 items, chosen as a result of an item analysis carried out by the University of Bristol Department of Child Health.
Effective school leadership

n considering the recent leadership literature it is ~ apparent that the views of headteachers still continue to dominate thinking and discussion about leadership (Tomlinson et al, 1999; MacBeath et al, 1999). The international literature contains many accounts of effective leadership emanating directly from headteachers, which rarely reflect the views of others within the school (Day et al, 1999;2000). As Hall and Southworth (1997) noted a few years ago, the idea that powerful and visionary heads enhance the school’s effectiveness is thus a
Intimacy, rites of passage and social support: symbolic meaning from lifetime shopping experiences

What meanings might one draw from a lifetime of shopping? Shopping embodies multiple meanings for those who engage in its practice. Employing the theory of symbolic interaction the symbolic meaning of consumer shopping experiences over the course of consumer lifetimes are examined. Twenty-five semi-structured, in-depth interviews were conducted with older consumers who were asked to reflect upon their lifetime of shopping experiences. Three convergent themes emerged relating to shopping: (1) intimacy, (2) rites of passage, and (3) social support. The themes drawn from the research help clarify the symbolic meanings derived from social interactions consumers experience when shopping, thus enhancing our understanding of consumer shopping behavior. Implications for academics and practitioners are discussed.
Do not cut the grass: expressions of British Gypsy-Traveller identity on cemetery memorials

Abstract The reported absence of distinguishing features upon British Gypsy-Traveller memorials has been used to support the widely accepted, and influential, argument that dead people are not the focus of social continuity within Gypsy-Traveller society. However, based upon cemetery surveys and interviews with members of the Gypsy-Traveller community in Sheffield, England, this paper demonstrates that explicit displays of ethnicity are now common upon memorials, and describes their characteristics. The reasons behind this apparent shift in mortuary practices are discussed in relation to wider socio-political factors. Based upon these findings, we argue for a reconsideration of the relationship between living and dead people within British Gypsy-Traveller society, and a recognition of the importance of commemoration in the negotiation of identity and social reproduction within these communities.
A search for good convolutional codes to be used in the construction of turbo codes

Recursive systematic convolutional encoders have been shown to play a crucial role in the design of turbo codes. We recall some properties of binary convolutional encoders and apply them to a search for good constituent convolutional codes of turbo codes. Tables of the "best" recursive systematic convolutional encoders found are presented for various rates, together with the average bit-error probability performances of some turbo codes using them.
Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthma

Effector memory T-cells (CD45RO+) may provide pro-inflammatory signals that contribute to the persistent airway inflammation that is characteristic of asthma, and reduced apoptosis of these cells may prolong their effects. The present authors compared apoptosis of CD45RO+ T-cells in the inner airway wall in nonfatal asthma (n = 7), fatal asthma (n = 7) and control (n = 8) cases. Apoptotic cells were identified using both the terminal deoxynucleotidyl transferase dNTP nick end-labelling (TUNEL) technique and cell morphology. The percentage of CD45RO+ T-cells that were apoptotic was significantly greater in control cases compared with nonfatal and fatal cases of asthma, respectively, in small (42±19, 16±9, 7±6%), medium (40±12, 15±11, 12±8%) and large airways (42±15, 23±18, 18±12%). The reduction in the percentage of apoptotic CD45RO+ cells in the cases of asthma was observed in both blood vessels and the interstitium in large airways. In conclusion, these data suggest that reduced apoptosis may prolong the active life of effector memory T-cells in the airways. It is possible that survival signals may be received before cells migrate into the interstitium of the inner airway wall.
Semantic feature analysis treatment in Spanish–English and French–English bilingual aphasia

Background: Edmonds and Kiran (2006) reported that training lexical retrieval in one language resulted in within‐language and cross‐language generalisation in three bilingual (English–Spanish) patients with aphasia. Aims: The present experiment continues this line of research, repeating a similar procedure with new patients and examining a broader range of factors that may affect generalisation patterns. Methods & Procedures: Four participants (two Spanish–English and two French–English speakers) with anomia post CVA received a semantic feature‐based treatment aimed at improving naming of English or Spanish/French nouns. Using a multiple baseline design, generalisation to untrained semantically related and unrelated items in each language was measured during periods of therapy first in one language, then in the other. Outcomes & Results: All patients improved their naming of the trained items in the trained language, although to varying degrees. Within‐language generalisation to semantically related items occurred in two Spanish–English patients and one French–English patient. Cross‐language generalisation to translations and semantically related items occurred only for one French–English patient. Conclusions: The impact of the intervention is very clear. The semantic feature‐based practice is linked to the gains made, and accounts for the predominance of semantic naming errors after treatment. Possible explanations for the different patterns of generalisation are considered in terms of the various factors including each patient's pre‐stroke language proficiency, age of acquisition of each language, post‐stroke level of language impairment, and type and severity of aphasia.
Analysis of the Fibrinogen and Neutrophil–Lymphocyte Ratio in Esophageal Squamous Cell Carcinoma

Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignancies in gastrointestinal tract cancers and even patients with early ESCC have a high metastatic potential. Difficulties are associated with clinically predicting tumor progression and prognosis based on conventional tumor markers determined from preoperative blood examinations. The aim of the present study was to measure plasma fibrinogen levels and the neutrophil–lymphocyte ratio (NLR) in blood and compare the clinical impacts of their combined values (fibrinogen and neutrophil–lymphocyte ratio score—F-NLR score) and the modified Glasgow Prognostic Score (mGPS) in patients with ESCC. We classified 238 patients with ESCC based on cut-off values for hyperfibrinogenemia (>400 mg/dL) and high NLR (>3.0) as F-NLR scores of 2 (both of these hematological abnormalities), 1 (one of these abnormalities), or 0 (neither abnormality). We also categorized patients based on cut-off values for high C-reactive protein (CRP) (>0.5 mg/dL) and hypoalbuminemia (<3.8 g/dL) as mGPS of 2 (elevated CRP and hypoalbuminemia), 1 (either elevated CRP or hypoalbuminemia), or 0 (neither elevated CRP nor hypoalbuminemia). The F-NLR score correlated with the depth of tumor invasion, lymph node metastasis, lymphovascular invasion, tumor size, and stage (all P < 0.05). Prognoses among the groups based on the F-NLR score and mGPS significantly differed (all P < 0.001). A multivariate analysis identified the depth of tumor invasion, lymph node metastasis, and F-NLR score as independent prognostic factors (P = 0.002, P = 0.007, and P = 0.037, respectively). The results of the present study showed that the F-NLR score is a promising blood predictor for tumor progression and outcomes in patients with ESCC.
Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression

Triple-negative breast cancer (TNBC) is currently the most malignant subtype of breast cancers without effective targeted therapies. Mifepristone (MIF), a drug regularly used for abortion, has been reported to have anti-tumor activity in multiple hormone-dependent cancers, including luminal type breast cancers. In this study, we showed that MIF suppressed tumor growth of the TNBC cell lines and patient-derived xenografts in NOD-SCID mice. Furthermore, MIF reduced the TNBC cancer stem cell (CSC) population through down-regulating KLF5 expression, a stem cell transcription factor over-expressed in basal type TNBC and promoting cell proliferation, survival and stemness. Interestingly, MIF suppresses the expression of KLF5 through inducing the expression of miR-153. Consistently, miR-153 decreases CSC and miR-153 inhibitor rescued MIF-induced down-regulation of the KLF5 protein level and CSC ratio. Taken together, our findings suggest that MIF inhibits basal TNBC via the miR-153/KLF5 axis and MIF may be used for the treatment of TNBC.
The Complement System in Neuropathic and Postoperative Pain

Certain types of pain are major unmet medical needs that affect more than 8 percent of the population. Neuropathic pain can be caused by many pathogenic processes including injury, autoimmune disease, neurological disease, endocrine dysfunction, infection, toxin exposure, and substance abuse and is frequently resistant to available pain therapies. The same can be said of postsurgical pain, which can arise from uncontrolled inflammation around the wound site. The complement system is part of the innate immune system and can both initiate and sustain acute and chronic inflammatory pain. Here we review the complement system and original investigations that identify potential drug targets within this system. Drugs that act to inhibit the complement system could fill major gaps in our current standard of care for neuropathic pain states.
Similar Paintings by Children , Chimps , Monkeys , and Elephants Seeing the Mind Behind the Art : People Can Distinguish Abstract Expressionist Paintings From Highly

Museumgoers often scoff that costly abstract expressionist paintings could have been made by a child and have mistaken paintings by chimpanzees for professional art. To test whether people really conflate paintings by professionals with paintings by children and animals, we showed art and nonart students paired images, one by an abstract expressionist and one by a child or animal, and asked which they liked more and which they judged as better. The first set of pairs was presented without labels; the second set had labels (e.g., “artist,” “child”) that were either correct or reversed. Participants preferred professional paintings and judged them as better than the nonprofessional paintings even when the labels were reversed. Art students preferred professional works more often than did nonart students, but the two groups’ judgments did not differ. Participants in both groups were more likely to justify their selections of professional than of nonprofessional works in terms of artists’ intentions. The world of abstract art is more accessible than people realize.
Differential space-time block codes

We propose a new differential modulation scheme for multiple-antenna systems based on square space-time block codes (STBC) when neither the transmitter nor the receiver knows channel state information. Compared with the known differential unitary space-time modulation (DUSTM), the proposed constellations generally have multiple amplitudes and do not have group properties. This generalization potentially allows the spectral efficiency to be increased by carrying information not only on orientations (or phases) but also on amplitudes. Two non-coherent decoders, optimal differential decoder (DD) and near-optimal DD, are derived for flat Rayleigh fading channels. Particularly, the near-optimal DD inherits the decomposition decoding property retained by STBC with coherent receiver and thus has linear complexity. Compared with the best-known cyclic group constellations designed for DUSTM, our proposed constellations with the near-optimal DD have significantly lower probability of error and lower decoding complexity.
Accounting for sex differences in PTSD: A multi-variable mediation model

Background Approximately twice as many females as males are diagnosed with posttraumatic stress disorder (PTSD). However, little is known about why females report more PTSD symptoms than males. Prior studies have generally focused on few potential mediators at a time and have often used methods that were not ideally suited to test for mediation effects. Prior research has identified a number of individual risk factors that may contribute to sex differences in PTSD severity, although these cannot fully account for the increased symptom levels in females when examined individually. Objective The present study is the first to systematically test the hypothesis that a combination of pre-, peri-, and posttraumatic risk factors more prevalent in females can account for sex differences in PTSD severity. Method The study was a quasi-prospective questionnaire survey assessing PTSD and related variables in 73.3% of all Danish bank employees exposed to bank robbery during the period from April 2010 to April 2011. Participants filled out questionnaires 1 week (T1, N=450) and 6 months after the robbery (T2, N=368; 61.1% females). Mediation was examined using an analysis designed specifically to test a multiple mediator model. Results Females reported more PTSD symptoms than males and higher levels of neuroticism, depression, physical anxiety sensitivity, peritraumatic fear, horror, and helplessness (the A2 criterion), tonic immobility, panic, dissociation, negative posttraumatic cognitions about self and the world, and feeling let down. These variables were included in the model as potential mediators. The combination of risk factors significantly mediated the association between sex and PTSD severity, accounting for 83% of the association. Conclusions The findings suggest that females report more PTSD symptoms because they experience higher levels of associated risk factors. The results are relevant to other trauma populations and to other trauma-related psychiatric disorders more prevalent in females, such as depression and anxiety.
Augmenting simulated annealing to build interaction test suites

Component based software development is prone to unexpected interaction faults. The goal is to test as many-potential interactions as is feasible within time and budget constraints. Two combinatorial objects, the orthogonal array and the covering array, can be used to generate test suites that provide a guarantee for coverage of all t-sets of component interactions in the case when the testing of all interactions is not possible. Methods for construction of these types of test suites have focused on two main areas. The first is finding new algebraic constructions that produce smaller test suites. The second is refining computational search algorithms to find smaller test suites more quickly. In this paper we explore one method for constructing covering arrays of strength three that combines algebraic constructions with computational search. This method leverages the computational efficiency and optimality of size obtained through algebraic constructions while benefiting from the generality of a heuristic search. We present a few examples of specific constructions and provide some new bounds for some strength three covering arrays.
Evolution of Gyrification in Carnivores

The order Carnivora is a large and highly diverse mammalian group with a long and well-documented evolutionary history. Nevertheless, our knowledge on the degree of cortical folding (or degree of gyrification) is limited to just a few species. Here we investigate the degree of cortical folding in 64 contemporary and 37 fossil carnivore species. We do so by measuring the length of gyri impressions on endocranial casts. We use this approach because we have found that there is a very good correlation between the degree of cortical folding and the relative length of the gyri that are exposed on the outer surface of the hemispheres. Our results indicate that aquatic and semiaquatic carnivores have higher degrees of cortical folding than terrestrial carnivores. The degree of cortical folding varies among modern families, with viverrids having the lowest values. Furthermore, the scaling of cortical folding with brain size follows different patterns across specific carnivore families. Forty million years ago, the first carnivores had a relatively small cortex and limited cortical folding. Both the size of the cortex and the degree of cortical folding increased independently in each family during evolution.