Miracle-dz/UniFAR-FTUs huggingface dataset:
The Haka network: Evaluating rugby team performance with dynamic graph analysis

Real world events are intrinsically dynamic and analytic techniques have to take into account this dynamism. This aspect is particularly important on complex network analysis when relations are channels for interaction events between actors. Sensing technologies open the possibility of doing so for sport networks, enabling the analysis of team performance in a standard environment and rules. Useful applications are directly related for improving playing quality, but can also shed light on all forms of team efforts that are relevant for work teams, large firms with coordination and collaboration issues and, as a consequence, economic development. In this paper, we consider dynamics over networks representing the interaction between rugby players during a match. We build a pass network and we introduce the concept of disruption network, building a multilayer structure. We perform both a global and a micro-level analysis on game sequences. When deploying our dynamic graph analysis framework on data from 18 rugby matches, we discover that structural features that make networks resilient to disruptions are a good predictor of a team's performance, both at the global and at the local level. Using our features, we are able to predict the outcome of the match with a precision comparable to state of the art bookmaking.
Dynamics of the impacts of Pratylenchus penetrans on Gisela® cherry rootstocks

Abstract Sweet cherry growers are increasingly using semi-dwarfing rootstocks, including the Gisela® series, when replanting orchards. Little is known of the susceptibility of these new cherry rootstocks to Pratylenchus penetrans, a recognized pest of temperate fruit trees worldwide. Two field experiments were planted in 2010, one in the Okanagan Valley of British Columbia and one in the Annapolis Valley of Nova Scotia. Each experiment was a factorial combination of three rootstocks (Gi.3, Gi.5, and Gi.6) × three training systems, with six replicate four-tree plots of each of the nine combinations. Both sites were fumigated prior to planting and population densities of P. penetrans in roots and root-zone soil were subsequently monitored from 2013 through 2017. None of the P. penetrans population parameters (nematodes/kg soil, nematodes/g fine root, and nematodes/kg soil including roots) differed among rootstocks at either site, suggesting that the rootstocks did not differ in their ability to host P. penetrans. At the British Columbia site only there was an inverse relationship between P. penetrans population densities and tree size for Gi.3 trees in four years and for Gi.6 in 2017, suggesting that Gi.3 rootstock is less tolerant than Gi.5 and Gi.6 rootstocks.
Protein phosphatase 1 and an opposing protein kinase regulate steady‐state L‐type Ca2+ current in mouse cardiac myocytes

Studies have suggested that integration of kinase and phosphatase activities maintains the steady‐state L‐type Ca2+ current in ventricular myocytes, a balance disrupted in failing hearts. As we have recently reported that the PP1/PP2A inhibitor calyculin A evokes pronounced increases in L‐type ICa, the goal of this study was to identify the counteracting kinase and phosphatase that determine ‘basal’ICa in isolated mouse ventricular myocytes. Whole‐cell voltage‐clamp studies, with filling solutions containing 10 mm EGTA, revealed that calyculin A (100 nm) increased ICa at test potentials between −42 and +49mV (44% at 0mV) from a holding potential of −80mV. It also shifted the V0.5 (membrane potential at half‐maximal) of both activation (from −17 to −25mV) and steady‐state inactivation (from −32 to −37mV) in the hyperpolarizing direction. The broad‐spectrum protein kinase inhibitor, staurosporine (300 nm), was without effect on ICa when added after calyculin A. However, by itself, staurosporine decreased ICa throughout the voltage range examined (50% at 0mV) and blocked the response to calyculin A, indicating that the phosphatase inhibitor's effects depend upon an opposing kinase activity. The PKA inhibitors Rp‐cAMPs (100 μm in the pipette) and H89 (1 μm) failed to reduce basal ICa or to block the calyculin A‐evoked increase in ICa. Likewise, calyculin A was still active with 10 mm intracellular BAPTA or when Ba2+ was used as the charge carrier. These data eliminate roles for protein kinase A (PKA) and calmodulin‐dependent protein kinase II (CaMKII) as counteracting kinases. However, the protein kinase C (PKC) inhibitors Ro 31‐8220 (1 μm) and Gö 6976 (200 nm) decreased steady‐state ICa and blunted the effect of calyculin A. PP2A is not involved in this regulation as intracellular applications of 10–100 nm okadaic acid or 500 nm fostriecin failed to increase ICa. However, PP1 is important, as dialysis with 2 μm okadaic acid or 500 nm inhibitor‐2 mimicked the increases in ICa seen with calyculin A. These in situ studies identify constitutive activity of PP1 and the counteracting activity of certain isoforms of PKC, in pathways distinct from receptor‐mediated signalling cascades, as regulatory components that determine the steady‐state level of cardiac L‐type ICa.
Novel Paramyxoviruses in Free-Ranging European Bats

The zoonotic potential of paramyxoviruses is particularly demonstrated by their broad host range like the highly pathogenic Hendra and Nipah viruses originating from bats. But while so far all bat-borne paramyxoviruses have been identified in fruit bats across Africa, Australia, South America, and Asia, we describe the detection and characterization of the first paramyxoviruses in free-ranging European bats. Moreover, we examined the possible impact of paramyxovirus infection on individual animals by comparing histo-pathological findings and virological results. Organs from deceased insectivorous bats of various species were sampled in Germany and tested for paramyxovirus RNA in parallel to a histo-pathological examination. Nucleic acids of three novel paramyxoviruses were detected, two viruses in phylogenetic relationship to the recently proposed genus Jeilongvirus and one closely related to the genus Rubulavirus. Two infected animals revealed subclinical pathological changes within their kidneys, suggestive of a similar pathogenesis as the one described in fruit bats experimentally infected with Hendra virus. Our findings indicate the presence of bat-born paramyxoviruses in geographic areas free of fruit bat species and therefore emphasize a possible virus–host co-evolution in European bats. Since these novel viruses are related to the very distinct genera Rubulavirus and Jeilongvirus, a similarly broad genetic diversity among paramyxoviruses in other Microchiroptera compared to Megachiroptera can be assumed. Given that the infected bats were either found in close proximity to heavily populated human habitation or areas of intensive agricultural use, a potential risk of the emergence of zoonotic paramyxoviruses in Europe needs to be considered.
Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER

Our laboratory was interested in characterizing the molecular composition of non-caveolar lipid rafts. Thus, we generated monoclonal antibodies to lipid raft proteins of human myelomonocytic cells. Two of these proteins, KE04p and C8orf2, were found to be highly enriched in the detergent-insoluble, buoyant fraction of sucrose gradients in a cholesterol-dependent manner. They contain an evolutionarily conserved domain placing them in the prohibitin family of proteins. In contrast to other family members, these two proteins localized to the ER. Furthermore, the extreme N-termini of KE04p and C8orf2 were found to be sufficient for heterologous targeting of GFP to the ER in the absence of classical ER retrieval motifs. We also demonstrate that all prohibitin family members rely on sequences in their extreme N-termini for their distinctive subcellular distributions including the mitochondria, plasma membrane and Golgi vesicles. Owing to their subcellular localization and their presence in lipid rafts, we have named KE04p and C8orf2, ER lipid raft protein (erlin)-1 and erlin-2, respectively. Interestingly, the ER contains relatively low levels of cholesterol and sphingolipids compared with other organelles. Thus, our data support the existence of lipid-raft-like domains within the membranes of the ER.
The Effect of Body Composition and Physical Fitness Factors on Performance Prediction of Elite Male Trampolines.

The main purpose of this study was the effect of body composition and physical fitness factors on performance prediction of elite male trampolines. So, 45 male athletes, who participated in the national trampoline team's preparation camps for participation at the 2014 Asian Games in four age categories included Children, Juniors, Adolescents and Seniors were selected using targeted sampling as subjects. Variables of study included 24 body composition indices and 20 physical fitness factors which were measured using standard procedures and instruments. Data were analyzed using Pearson correlation coefficient and multiple regression models at the 0.05 significance level. Results of study showed that, the relationships of the shoulder belt muscle strength ( r =0.294) with performance are statistically significant and in other cases, there was no significant relationships ( p >0.05). Results of study showed the relationships of the shoulder belt muscle strength ( r =0.294), aerobic power ( r =0.351), relative minimum anaerobic power ( r =0.256), with performance are statistically significant.and in other cases, observed relationships were not statistically significant ( p >0.05). Findings of this study suggest that, in the high competitive level of trampoline body composition indices do not have predictive role in preparation programs of elite male trampolines, but physical factors have predictive role in preparation programs of elite male trampolines.
Cerebral correlates of faking: evidence from a brief implicit association test on doping attitudes

Direct assessment of attitudes toward socially sensitive topics can be affected by deception attempts. Reaction-time based indirect measures, such as the Implicit Association Test (IAT), are less susceptible to such biases. Neuroscientific evidence shows that deception can evoke characteristic ERP differences. However, the cerebral processes involved in faking an IAT are still unknown. We randomly assigned 20 university students (15 females, 24.65 ± 3.50 years of age) to a counterbalanced repeated-measurements design, requesting them to complete a Brief-IAT (BIAT) on attitudes toward doping without deception instruction, and with the instruction to fake positive and negative doping attitudes. Cerebral activity during BIAT completion was assessed using high-density EEG. Event-related potentials during faking revealed enhanced frontal and reduced occipital negativity, starting around 150 ms after stimulus presentation. Further, a decrease in the P300 and LPP components was observed. Source analyses showed enhanced activity in the right inferior frontal gyrus between 150 and 200 ms during faking, thought to reflect the suppression of automatic responses. Further, more activity was found for faking in the bilateral middle occipital gyri and the bilateral temporoparietal junction. Results indicate that faking reaction-time based tests alter brain processes from early stages of processing and reveal the cortical sources of the effects. Analyzing the EEG helps to uncover response patterns in indirect attitude tests and broadens our understanding of the neural processes involved in such faking. This knowledge might be useful for uncovering faking in socially sensitive contexts, where attitudes are likely to be concealed.
Determination of Kupffer Cell Fc Receptor Function In Vivo following Injury

Abstract This study was carried out to determine whether Kupffer cell Fc receptor function is depressed after injury. Three approaches to the determination of Fc receptor function were evaluated: IgG-coated erythrocytes (EIgG) were used as the receptor probe with a perfused liver system, EIgG were used as the receptor probe in vivo, and small aggregates of IgG (AIgG) were used as the receptor probe in vivo. Nearly half of the injected dose of EIgG was taken up by the perfused liver (nonrecirculating, serum-free system). In contrast, only 2.6% of erythrocytes not coated with IgG were taken up, and only 5.6% of erythrocytes coated with IgM were taken up by the perfused liver. Thus, there was little nonspecific or complement-dependent uptake of EIgG by the liver. The uptake of EIgG by the perfused liver was depressed following thermal injury, endotoxemia, and the phagocytosis of EIgG. These results were interpreted as indicating that Kupffer cell Fc receptor function was depressed under these conditions. The results obtained with the hepatic uptake of EIgG in vivo were very similar to those with EIgG in the perfused liver. However, since it was found that complement receptors as well as Fc receptors were probably involved in the in vivo clearance of EIgG, these results could be due to a depression of one or both of these receptors. The hepatic uptake of AIgG was not depressed by complement depletion, but was decreased by the injection of large aggregates of IgG. However, the hepatic uptake of AIgG was not depressed following thermal injury, endotoxemia, or the phagocytosis of EIgG. Thus, AIgG was not sensitive to the effects of injury on Kupffer cell function, whereas the uptake of EIgG by the perfused liver may provide an indication of Kupffer cell Fc receptor function. The depression of Kupffer cell Fc receptor function following injury may contribute to the impairment of host defense caused by injury.
Adaptive cruise control: Experimental validation of advanced controllers on scale-model cars

Recent advances in automotive technology, such as, sensing and onboard computation, have resulted in the development of adaptive cruise control (ACC) algorithms that improve both comfort and safety. With a view towards developing advanced controllers for ACC, this paper presents an experimental platform for validation and demonstration of an online optimization based controller. Going beyond traditional PID based controllers for ACC that lack proof of safety, we construct a control framework that gives formal guarantees of correctness. In particular, safety constraints-maintaining a valid following distance from a lead car-are represented by control barrier functions (CBFs), and control objectives- achieving a desired speed-are encoded through control Lyapunov functions (CLFs). These different objectives can be unified through a quadtraic program (QP), with constraints dictated by CBFs and CLFs, that balances safety and the control objectives in an optimal fashion. This methodology is demonstrated on scale-model cars, for which the CBF-CLF based controller is implemented online, with the end result being the experimental validation of an advanced adaptive cruise controller.
Seroepidemiological investigation of Brucella canis antibodies in different human population groups

A study was conducted to determine the prevalence of Brucella canis antibodies in specified groups based on their exposure to dogs. The method used was a microtiter technique, and the presence of antibodies at a 1:12 or greater dilution of serum was considered a positive test. Eleven (5.7%) of the newborn infants had evidence of maternal antibodies, and 67.8% of the persons with an average exposure to dogs had B. canis antibodies, with a 62.1% prevalence in males and a 72.4% prevalence in females (P less than or equal to 0.001). Veterinarians had a much higher rate of infection (72.6%) than male blood donors (56.9%) (P less than or equal to 0.01). Patients with fevers of undetermined origin had significantly higher antibody titers to B. canis than all other patients (P less than or equal to 0.001). This study presents evidence that the prevalence of B. canis antibodies in humans is high, and that the incidence of brucellosis may increase when physicians consider B. canis as a possible etiological agent in febrile illnesses.
Differential regulation of apoptosis-associated genes by estrogen receptor alpha in human neuroblastoma cells.

PURPOSE The neuroendocrinology of female sex hormones is of great interest for a variety of neuropsychiatric disorders. In fact, estrogens and estrogen receptors (ERs) exert neuromodulatory and neuroprotective functions. Here we investigated potential targets of the ER subtype alpha that may mediate neuroprotection and focused on direct modulators and downstream executors of apoptosis. METHODS We employed subclones of human neuroblastoma cells (SK-N-MC) stably transfected with one of the ER subtypes, ERalpha or ERbeta. Differences between the cell lines regarding the mRNA expression levels were examined by qPCR, changes on protein levels were examined by Western Blot and immunocytochemistry. Differences concerning apoptosis induction were analysed by cell survival assays which included primary rat neurons. RESULTS In this report we show a potent protection against apoptosis-stimuli in ERalpha expressing cells compared to controls lacking ERalpha. In fact, almost a complete silencing of Caspase 3 expression in SK-ERalpha cells compared to SK-01 control transfected cells was observed. In addition, prosurvival bcl2, bag1 and bag3 expression was highly up-regulated in the presence of ERalpha. CONCLUSION Taken together, we identified Caspase 3, BAG1 and BAG3 as key targets of ERalpha in neuronal cells that may play a role in ERalpha-mediated neuroprotection.
Cost and environmental efficiency of rice farms in South Korea

We examine cost and nutrient use efficiency of farms and determine the cost to move farms to nutrient-efficient operation using Data Envelopment Analysis (DEA) with a dataset of 96 rice farms in Gangwon province of South Korea from 2003 to 2007. Our findings show that improvements in technical efficiency would result in both lower production costs and better environmental performance. It is, however, not costless for farms to move from their current operation to the environmentally efficient operation. On average, this movement would increase production costs by 119% but benefit the water system through an approximately 69% reduction in eutrofying power (EP). The average estimated cost of each EP kg of aggregate nutrient reduction is approximately one thousand two hundred won. For technically efficient farms, there is a trade-off between cost and environmental efficiency. We also find that the environmental performance of farms varies across farms and regions. We suggest that agri-environmental policies should be (re)designed to improve both cost and environmental performance of rice farms.
Papillary Thyroid Carcinoma Intertwined with Hashimoto’s Thyroiditis: An Intriguing Correlation

Illustrating the ancient link connecting inflammation with cancer, the correlation of papillary thyroid carcinoma (PTC) with Hashimoto’s thyroiditis (HT) has long been pursued as intersection of autoimmunity-induced chronic inflammation and tumor-induced immunity. The dramatic rise of the incidence of PTC ο ver the last decades—the main culprit for “thyroid cancer (TC) epidemic”—parallels the increasing incidence of HT, potentially reflecting a pathogenetic link that could be harnessed in diagnostics and therapeutics. Prompted by this perspective, in the present chapter, we dissect the hitherto elusive interrelationship of PTC with HT, focusing on four issues: firstly, an unresolved conundrum is whether PTC emerges due to or notwithstanding immune response or mirrors the “tumor defense-induced autoimmunity. ” Secondly, the interrelationship of HT with PTC may be merely epiphenomenon of selection bias inherent in thyroidectomy series. Thirdly, the impact of HT on coexistent PTC is equivocal—host protective versus tumor protective. Fourthly, translating serum concentrations of thyroid autoantibodies and thyroid-stimulating hormone (TSH) into predictive and prognostic PTC biomarkers dichotomizes, till now, the researchers. In the era of precision medicine, illuminating whether HT precipitates PTC or vice versa is awaited with anticipation in order to refine the preventive and therapeutic policy counteracting “TC epidemic. ”
Technical debt in MDE: a case study on GMF/EMF-based projects

Technical Debt (TD) is a metaphor referring to immature software artifacts that can hurt the long-term maintenance of a system. Model-Driven Engineering (MDE) is a model-centric software development approach, which promises better maintainability. However, there is a lack of empirical evidence on the existence and influence of TD in the context of MDE. This paper investigates the code-level TD in MDE projects, which is incurred during code generation. We evaluated 16 open-source and non-trivial GMF/EMF-based MDE projects using bad smells, which are widely-accepted TD indicators. The results demonstrate that MDE is not TD-free, and code generators also incur TD, similarly to developers. In fact, the generated code usually contains more TD than handwritten code, which influences significantly the maintenance of MDE projects.
The effect of antiphase boundaries on the elastic properties of Ni–Mn–Ga austenite and premartensite

The evolution of elastic properties with temperature and magnetic field was studied in two differently heat-treated single crystals of the Ni–Mn–Ga magnetic shape memory alloy using resonant ultrasound spectroscopy. Quenching and slow furnace cooling were used to obtain different densities of antiphase boundaries. We found that the crystals exhibited pronounced differences in the c′ elastic coefficient and related shear damping in high-temperature ferromagnetic phases (austenite and premartensite). The difference can be ascribed to the formation of fine magnetic domain patterns and pinning of the magnetic domain walls on antiphase boundaries in the material with a high density of antiphase boundaries due to quenching. The fine domain pattern arising from mutual interactions between antiphase boundaries and ferromagnetic domain walls effectively reduces the magnetocrystalline anisotropy and amplifies the contribution of magnetostriction to the elastic response of the material. As a result, the anomalous elastic softening prior to martensite transformation is significantly enhanced in the quenched sample. Thus, for any comparison of experimental data and theoretical calculations the microstructural changes induced by specific heat treatment must be taken into account.
Social Support and Adjustment in Patients with Sarcoma: The Moderator Effect of the Disease Phase

This study examined the association between different types of perceived social support and adjustment of patients with sarcoma, and if these relationships would differ depending on the outcome measure and phase of disease. Forty-nine patients in the diagnostic phase, 43 in the treatment phase, and 59 in the follow-up phase were recruited. Participants completed the Medical Outcomes Study Social Support Survey Questionnaire, the Hospital Anxiety and Depression Scale, and World Health Organization Quality of Life Assessment. Positive social interaction, emotional/informational, affectionate, and tangible supports were significantly associated with depression scores, but not with anxiety. Except for affectionate support, all the associations with overall quality of life were significant. A moderating effect of the phase of the disease was also found in the association between tangible support and anxiety, and between affectionate support, depression, and overall quality of life. In clinical practice it is important to implement phase-specific psychosocial interventions and to take into consideration other factors beyond perceived social support while handling patients with sarcoma.