Miracle-dz/UniFAR-FTUs huggingface dataset:
Hop timing estimation for noncoherent frequency-hopped M-FSK intercept receivers

The optimum hop timing estimator, based on classical likelihood-ratio (LR) theory, is derived for noncoherent slow and fast frequency-hopped M-FSK intercept receivers. Such receivers have no a priori knowledge of the hopping code and thus the solution to this estimation problem differs considerably from the more commonly considered case of the friendly receiver. The implementation and performance of the LR hop timing structures are presented and compared with that of other previously documented suboptimum schemes. In particular, when compared to the multiple-hop autocorrelation (MHAC) approach and the "ping-pong" approach, the average-likelihood ratio (ALR) and maximum-likelihood ratio (MLR) optimum estimators offer an improvement in performance of several dB in input SNR. Robustness issues for the optimal estimator are examined and alternative configurations are proposed that offer enhanced insensitivity to unknown frequency offsets. >
Varicella-Zoster Virus IE63 Protein Phosphorylation by Roscovitine-sensitive Cyclin-dependent Kinases Modulates Its Cellular Localization and Activity*

During the first stage of Varicella-Zoster virus (VZV) infection, IE63 (immediate early 63 protein) is mostly expressed in the nucleus and also slightly in the cytoplasm, and during latency, IE63 localizes in the cytoplasm quite exclusively. Because phosphorylation is known to regulate various cellular mechanisms, we investigated the impact of phosphorylation by roscovitine-sensitive cyclin-dependent kinase (RSC) on the localization and functional properties of IE63. We demonstrated first that IE63 was phosphorylated on Ser-224 in vitro by CDK1 and CDK5 but not by CDK2, CDK7, or CDK9. Furthermore, by using roscovitine and CDK1 inhibitor III (CiIII), we showed that CDK1 phosphorylated IE63 on Ser-224 in vivo. By mutagenesis and the use of inhibitors, we demonstrated that phosphorylation on Ser-224 was important for the correct localization of the protein. Indeed, the substitution of these residues by alanine led to an exclusive nuclear localization of the protein, whereas mutations into glutamic acid did not modify its subcellular distribution. When transfected or VZV-infected cells were treated with roscovitine or CiIII, an exclusive nuclear localization of IE63 was also observed. By using a transfection assay, we also showed that phosphorylation on Ser-224 and Thr-222 was essential for the down-regulation of the basal activity of the VZV DNA polymerase gene promoter. Similarly, roscovitine and CiIII impaired these properties of the wild-type form of IE63. These observations clearly demonstrated the importance of CDK1-mediated IE63 phosphorylation for a correct distribution of IE63 between both cellular compartments and for its repressive activity toward the promoter tested.
Vivo 3T MRI Study Stenosis in Asymptomatic Patients: An In Atherosclerotic Plaque with Less Than 50% Sex Differences of High-Risk Carotid

BACKGROUNDANDPURPOSE: Menhaveagreaterprevalenceofhigh-riskcarotidplaquefeaturesassociatedwithstrokecomparedwith women who have (cid:1) 50% stenosis, but little is known about these features in less signiﬁcantly stenotic carotid arteries. This study aims to evaluate sex differences in complicated carotid plaque features in asymptomatic patients with (cid:1) 50% stenosis. MATERIALS AND METHODS: Ninety-six patients (50 men, 46 women) with (cid:1) 50% carotid stenosis on MRA who had been referred for analysis of contralateral (cid:2) 50% carotid stenosis were included. The associations between sex and plaque features as identiﬁed by 3T MR carotid plaque imaging were examined by using logistic and linear regression models controlling for demographic characteristics, MRA stenosis, and the presence of contralateral plaque features. RESULTS: Thepresenceofathin/rupturedﬁbrouscap(16%versus2%,adjustedoddsratio (cid:3) 8.57, P (cid:3) . 047),IPH(24%versus6%,adjustedodds ratio (cid:3) 4.53, P (cid:3) . 027),andAmericanHeartAssociationtypeVIplaque(26%versus6%,adjustedoddsratio (cid:3) 5.04, P (cid:3) . 017)wassigniﬁcantlyhigher in men than in women. These associations remained signiﬁcant following adjustment for contralateral plaque features. Men demonstrated a larger percentage volume of LR/NC (median, 1.66% versus (cid:4) 0.21%; P (cid:1) . 01). Calciﬁcation was not signiﬁcantly associated with sex. CONCLUSIONS: Thereisasexdifferenceofhigherriskcarotidplaquefeaturesduringtheearlystageofdiseaseseeninpatientsrecruited for MR imaging evaluation of contralateral moderate-to-severe stenosis. Given the potential of using LR/NC without or with IPH to monitor therapy, these results indicate the possible importance of sex-based management in patients with asymptomatic carotid atherosclerosis across all stages of carotid stenosis