Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between Interleukin-6 Promoter Polymorphism (-174 G/C), Serum Interleukin-6 Levels and Mortality in Severe Septic Patients

The association between interleukin (IL)-6 promoter polymorphism (-174 G/C), circulating IL-6 levels and mortality in septic patients has scarcely been addressed, and then only in studies of small sample size, and a direct association among them has not been previously reported. Therefore, the purpose of our study was to determine whether this association exists. An observational, prospective and multicenter study including severe septic patients was undertaken and serum IL-6 levels at severe sepsis diagnosis and IL-6 promoter polymorphism (-174 G/C) were determined. The end-point of the study was 30-day mortality. The study included 263 patients with the following genotypes of IL-6 promoter polymorphism (-174 G/C): 123 (46.8%) GG, 110 (41.8%) GC and 30 (11.4%) CC. CC homozygous patients showed lower sepsis-related organ failure assessment (SOFA) score, serum IL-6 levels and mortality at 30 days compared to those with other genotypes (GC or GG). On regression analysis, CC homozygous patients showed lower 30-day mortality than those with genotype GG (odds ratio = 0.21; 95% CI = 0.053−0.838; p = 0.03) or GC (hazard ratio = 0.28; 95% CI = 0.074−1.037; p = 0.06). The most important results of our study were that CC might be a favorable genotype in septic patients showing lower serum IL-6 levels and lower risk of death within 30 days.
Success factors for software reuse that are applicable across domains and businesses

The problem researched is that there presently does not exist a set of success factors which are common across organizations and have some predictability relationship to software reuse. For completeness, this research also investigated possible predictive relationships between software reuse and both productivity and quality. A 1995 survey was conducted to determine the state-of-the-practice. The data from the survey was statistically analyzed to evaluate the relationships among reuse capability, productivity, quality, and the individual software reuse success factors. The results of the analysis showed some of the success factors to have a predictive relationship to software reuse capability. Software reuse capability also had a predictive relationship to productivity and quality. Based on the research results, the leading indicators of software reuse capability are: product-line approach, architecture which standardizes interfaces and data formats, common software architecture across the product-line, design for manufacturing approach, domain engineering, management which understands reuse issues, software reuse advocate(s) in senior management, state-of-the-art tools and methods, precedence of reusing high level software artifacts such as requirements and design versus just code reuse, and trace end-user requirements to the components (systems, subsystems, and/or software modules) which support them.
Organizational Pathologies in Police Intelligence Systems

During the 1990s serious and organized crime moved to the top of the agenda for policing internationally. This shift took place during the same period that new information and communications technologies were being adopted across the policing sector in most European countries, a shift known in some places as the rise of ‘intelligence-led policing’. Discussion of intelligence-led policing against serious and organized crime has tended to focus on formal models of intelligence systems. The purpose of this paper is to contribute to the vocabulary of intelligence-led policing by providing the terms for describing the organizational problems that bedevil the organization of police information systems. It is based on original empirical research in the United Kingdom and a number of other countries and provides a lexicon of 11 organizational pathologies. The paper ends by arguing that strategic intelligence forecasts about future trends in organized and serious crime that emanate from the police sector are not as strategic or as comprehensive as they appear to be.
Comparative Proteomic Analysis of Differential Proteins in Response to Aqueous Extract of Quercus infectoria Gall in Methicillin-Resistant Staphylococcus aureus

The aim of this study is to analyze the differential proteins in MRSA ATCC 33591 treated with aqueous extract from Q. infectoria gall. Protein extracts were obtained from MRSA cells by sonication and were separated by 2D polyacrylamide gels. Protein spots of interest were extracted from the gels and identified using LC-ESI-QTOF MS. The concentration of Q. infectoria extract used for 2D-gel electrophoresis was subinhibitory concentration. Minimum inhibitory concentration (MIC) value of the extract against MRSA was 19.50 μg/mL with bacteriostatic action at 1x MIC from time-kill assay. However, the extract exhibited dose-dependent manner and was bactericidal at 4x MIC with more than 3 log10 CFU/mL reduction at 4 h. 2D-GE map showed that 18 protein spots were upregulated and another six were downregulated more than twofold (p < 0.05) after treatment with subinhibitory concentration. Out of six proteins being downregulated, four proteins were identified as ferritin and catalase, branched-chain alpha-keto acid dehydrogenase subunit E2, and succinyl-CoA ligase [ADP-forming] subunit beta. Seven upregulated proteins which have been successfully identified were 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein, formate C-acetyltransferase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, NAD dependent epimerase/dehydratase family protein, and phosphopantothenoyl cysteine decarboxylase. It is postulated that the main mechanism of aqueous extract from gall of Q. infectoria was most likely involved in energy metabolism and protein stress.
Influencing the World Versus Adjusting to Constraints

Although higher social class carries mental and physical health benefits, these advantages are less robust among members of racial and ethnic minority groups than among European Americans. We explore whether differential reactions to discrimination may be a factor in explaining why. Working-class and middle-class Latino American women engaged in an evaluative interaction with a European American woman who rejected them and held either prejudiced or unprejudiced attitudes. We examined how participants responded to this rejection by measuring neuroendocrine reactivity, executive functioning, and the affective content of their verbal responses during the interaction. Among middle-class Latinas, rejection from a prejudiced, compared to unprejudiced, out-group member was associated with less adaptive stress responses, greater cognitive depletion, and more feelings of uncertainty. In contrast, among working-class Latinas, neuroendocrine, cognitive, and affective responses were similar across the two sources of rejection. Results suggest that social class is an important moderator of responses to discrimination.
Challenge models to assess new therapies in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Current therapies confer partial benefits either by incompletely improving airflow limitation or by reducing acute exacerbations, hence new therapies are desirable. In the absence of robust early predictors of clinical efficacy, the potential success of novel therapeutic agents in COPD will not entirely be known until the drugs enter relatively large and costly clinical trials. New predictive models in humans, and new study designs are being sought to allow for confirmation of pharmacodynamic and potentially clinically meaningful effects in early development. This review focuses on human challenge models with lipopolysaccharide endotoxin, ozone, and rhinovirus, in the early clinical development phases of novel therapeutic agents for the treatment and reduction of exacerbations in COPD.
Informing resource-poor populations and the delivery of entitled health and social services in rural India: a cluster randomized controlled trial.

CONTEXT A lack of awareness about entitled health and social services may contribute to poor delivery of such services in developing countries, especially among individuals of low socioeconomic status. OBJECTIVE To determine the impact of informing resource-poor rural populations about entitled services. DESIGN, SETTING, AND PARTICIPANTS Community-based, cluster randomized controlled trial conducted from May 2004 to May 2005 in 105 randomly selected village clusters in Uttar Pradesh state in India. Households (548 intervention and 497 control) were selected by a systematic sampling design, including both low-caste and mid- to high-caste households. INTERVENTION Four to 6 public meetings were held in each intervention village cluster to disseminate information on entitled health services, entitled education services, and village governance requirements. No intervention took place in control village clusters. MAIN OUTCOME MEASURES Visits by nurse midwife; prenatal examinations, tetanus vaccinations, and prenatal supplements received by pregnant women; vaccinations received by infants; excess school fees charged; occurrence of village council meetings; and development work in villages. RESULTS At baseline, there were no significant differences in self-reported delivery of health and social services. After 1 year, intervention villagers reported better delivery of several services compared with control villagers: in a multivariate analysis, 30% more prenatal examinations (95% confidence interval [CI], 17%-43%; P < .001), 27% more tetanus vaccinations (95% CI, 12%-41%; P < .001), 24% more prenatal supplements (95% CI, 8%-39%; P = .003), 25% more infant vaccinations (95% CI, 8%-42%; P = .004), and decreased excess school fees of 8 rupees (95% CI, 4-13 rupees; P < .001). In a difference-in-differences analysis, 21% more village council meetings were reported (95% CI, 5%-36%; P = .01). There were no improvements in visits by a nurse midwife or in development work in the villages. Both low-caste and mid- to high-caste intervention households reported significant improvements in service delivery. CONCLUSIONS Informing resource-poor rural populations in India about entitled services enhanced the delivery of health and social services among both low- and mid- to high-caste households. Interventions that emphasize educating resource-poor populations about entitled services may improve the delivery of such services. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00421291.
Rapid urease test is less sensitive than histology in diagnosing Helicobacter pylori infection in patients with non‐variceal upper gastrointestinal bleeding

Background and Aims : The validity of the rapid urease (CLO) test to diagnose Helicobacter pylori infection in patients with bleeding ulcers has been questioned. The aim of this paper is to evaluate the validity of the CLO test in comparison with histology in diagnosing H. pylori infection in patients with acute upper gastrointestinal bleeding (UGB), irrespective of non‐steroidal anti‐inflammatory drug (NSAID) use.
Gender: An Ethnomethodological Approach

Kessler and McKenna convincingly argue that gender is not a reflection of biological reality but rather a social construct that varies across cultures. Valuable for its insights into gender, its extensive treatment of transsexualism, and its ethnomethodological approach, "Gender" reviews and critiques data from biology, anthropology, sociology, and psychology.
The relationship between tourist motivations and the interpretation of place meanings

Abstract Current approaches in cultural geography suggest that how a place is interpreted is directly related to the metaphorical perspective from which that place is viewed. In other words, the meaning attributed to place is dependent on the orientations of particular groups and individuals. This idea was tested in the context of one nature‐based tourist place by investigating the link between place meanings and the motivational profiles of 879 visitors to the Daintree and Cape Tribulation area of far North Queensland, Australia. Motivational groups were identified using a factor‐cluster segmentation approach, while the meaning structure was developed by Young. Analysis of variance between the motivational clusters revealed that place was interpreted in the context of the motivational orientation of visitors. It is argued that by attributing selected meanings to place, visitors benefit psychologically through the fulfilment of motivational needs. Implications for management and research are discussed.
When Race Matters: Teachers' Evaluations of Students' Classroom Behavior

Past studies have noted that black students' classroom behavior is rated more favorably by black teachers than by white teachers. This pattern could be a function of white teachers' bias—rating black students more harshly than they deserve—or black students' misbehavior—acting out more when placed with white teachers versus black teachers. If explanations emphasizing black students' misbehavior (oppositional culture) are accurate, matching effects should be more substantial among adolescents than among young children. To assess this possibility, the authors estimated matching effects among kindergartners in the Early Childhood Longitudinal Study—Kindergarten Class of 1998-99 and eighth graders from the National Education Longitudinal Study of 1988. They found that the effects of matching are comparable across both kindergartners and adolescents, a pattern that is more readily understood from the position of white teachers' bias than from that of oppositional culture.
Prospects and challenges for the conservation of farm animal genomic resources, 2015-2025

Livestock conservation practice is changing rapidly in light of policy developments, climate change and diversifying market demands. The last decade has seen a step change in technology and analytical approaches available to define, manage and conserve Farm Animal Genomic Resources (FAnGR). However, these rapid changes pose challenges for FAnGR conservation in terms of technological continuity, analytical capacity and integrative methodologies needed to fully exploit new, multidimensional data. The final conference of the ESF Genomic Resources program aimed to address these interdisciplinary problems in an attempt to contribute to the agenda for research and policy development directions during the coming decade. By 2020, according to the Convention on Biodiversity's Aichi Target 13, signatories should ensure that “…the genetic diversity of …farmed and domesticated animals and of wild relatives …is maintained, and strategies have been developed and implemented for minimizing genetic erosion and safeguarding their genetic diversity. ” However, the real extent of genetic erosion is very difficult to measure using current data. Therefore, this challenging target demands better coverage, understanding and utilization of genomic and environmental data, the development of optimized ways to integrate these data with social and other sciences and policy analysis to enable more flexible, evidence-based models to underpin FAnGR conservation. At the conference, we attempted to identify the most important problems for effective livestock genomic resource conservation during the next decade. Twenty priority questions were identified that could be broadly categorized into challenges related to methodology, analytical approaches, data management and conservation. It should be acknowledged here that while the focus of our meeting was predominantly around genetics, genomics and animal science, many of the practical challenges facing conservation of genomic resources are societal in origin and are predicated on the value (e.g., socio-economic and cultural) of these resources to farmers, rural communities and society as a whole. The overall conclusion is that despite the fact that the livestock sector has been relatively well-organized in the application of genetic methodologies to date, there is still a large gap between the current state-of-the-art in the use of tools to characterize genomic resources and its application to many non-commercial and local breeds, hampering the consistent utilization of genetic and genomic data as indicators of genetic erosion and diversity. The livestock genomic sector therefore needs to make a concerted effort in the coming decade to enable to the democratization of the powerful tools that are now at its disposal, and to ensure that they are applied in the context of breed conservation as well as development.
Phylogeography of the red‐tailed chipmunk (Tamias ruficaudus), a northern Rocky Mountain endemic

The northern Rocky Mountains have experienced a complex history of geological events and environmental fluctuation, including Pleistocene glaciation. To provide an initial assessment of the genetic impact of this history on the regional biota we estimated phylogenetic relationships within Tamias ruficaudus, a regional endemic, from cytochrome b sequence variation using parsimony, maximum likelihood, and nested clade analysis. Analyses of sequence variation in 187 individuals from 43 localities across the distribution of T. ruficaudus indicate a history of vicariance events and range fluctuation consistent with successive periods of extensive Pleistocene glaciation in the northern Rocky Mountains. Intraspecific divergence levels (c. 4.7% uncorrected) and phylogenetic structure are consistent with a genealogical vicariance initiated prior to the Late Pleistocene, whereas nested clade analyses indicate more recent population history structured by both fragmentation and range expansion. A comparison of sequence variation with bacular morphology indicates that the two genetically and morphologically differentiated entities exhibit a zone of differential character introgression. Sequence data support a multiple refugia hypothesis and provide a phylogeographical case study for the ongoing synthesis of regional biogeography for northern Rocky Mountain endemics.
Associations of Identity Dimensions with Big Five Personality Domains and Facets

Personality is among the most important factors contributing to individual differences in identity formation. However, previous studies mainly focused on broad personality domains and neglected more specific facets. In addition, it has only recently been recognized that identity formation is guided by multiple types of commitment and exploration. The present study aimed to remedy these limitations by relating the 30 personality facets of the NEO–PI–3 to five identity dimensions. In general, identity formation was especially facilitated by high levels of Conscientiousness and, to a lesser extent, also by high levels of Extraversion and low levels of Neuroticism. Openness and Agreeableness predicted greater involvement in both the positive side (i.e. exploration in breadth and depth) and negative side (i.e. ruminative exploration) of the exploration process. Personality facets and their overarching domains, as well as facets underlying the same domain, were often differentially associated with identity dimensions. Additionally, we found that some personality facets both have bright and dark sides, as they predicted both proactive identity work and a weakened sense of identity. Overall, the present study underscores the utility of multidimensional models of identity formation and points to the benefits of considering personality facets in addition to broad domains. Copyright © 2012 John Wiley & Sons, Ltd.
Aspects of algebraic Algebras

In this paper we investigate important categories lying strictly between the Kleisli category and the Eilenberg-Moore category, for a Kock-Zoberlein monad on an order-enriched category. Firstly, we give a characterisation of free algebras in the spirit of domain theory. Secondly, we study the existence of weighted (co)limits, both on the abstract level and for specific categories of domain theory like the category of algebraic lattices. Finally, we apply these results to give a description of the idempotent split completion of the Kleisli category of the filter monad on the category of topological spaces.
Learners' Perceptions of Listening Comprehension Problems

Many EFL learners find that they are unable to comprehend natural spoken English delivered at normal speed. The paper reports a study of listening problems encountered in the EFL classroom in the ESP Centre at Damascus University, as reported by the learners themselves. It looks in particular at learner strategies, features of the listening text, characteristics of the speaker, attitudes of the listener, the task to be completed as a result of understanding the text, and the degree of visual or written support for the aural input. The results of the study show that EFL learners experience a range of listening problems. To overcome them, various techniques which help learners to utilise effective strategies to confront problems of listening comprehension are discussed and the pedagogic implications are stated.
Effect of postural changes on cardiovascular parameters across gender

Introduction: We investigated the effect of postural changes on various cardiovascular parameters across gender. Twenty-eight healthy subjects (16 male, 12 female) were observed at rest (supine) and subjected to 3 interventions; head-down tilt (HDT), HDT with lower body negative pressure (HDT+ LBNP at −30 mm Hg), and head-up tilt (HUT), each for 10 minutes separated by a 10 minutes recovery period. Methods: Measurements were recorded for heart rate (HR), standard deviation of the normal-to-normal intervals, root mean square of successive differences between the normal-to-normal intervals, heart rate variability-low frequency (LFRRI), heart rate variability-high frequency (HFRRI), low frequency/high frequency ratio (LFRRI/HFRRI), systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP), total peripheral resistance index (TPRI), stroke index (SI), cardiac index (CI), index of contractility (IC), left ventricular work index, and left ventricular ejection time. Results: Across all cardiovascular parameters, there was a significant main effect of the intervention applied but there was no significant main effect of gender across all parameters. Conclusions: The results suggest that there are no specific gender differences in regards to the measured variables under the conditions of this study. Furthermore, these results suggest that in healthy subjects, there appears to be evidence that LBNP partially elicits similar cardiovascular responses to HUT, which supports the use of LBNP as an intervention to counteract the effects of central hypovolemia.
Guilt proneness and expressed emotion in relatives of patients with schizophrenia or related psychoses.

OBJECTIVE Knowledge of what predicts relatives' expressed emotion (EE) may contribute to improved family work in schizophrenia. In the present study we examined guilt proneness as a determinant of EE components. METHOD In a Norwegian sample of 46 recently hospitalized patients (schizophrenia or schizophreniform disorder) and 69 relatives, relatives' expressed emotion was assessed by means of the Camberwell Family Interview, and guilt proneness by means of the Revised Mosher Guilt Inventory. (RMGI). RESULTS Confirmatory multiple regression analyses showed that hostility-guilt (RMGI) was negatively related to high levels of criticism and hostility and, for men, positively related to emotional overinvolvement. There was a strong positive relationship between relatives' guilty conscience (RMGI) and emotional overinvolvement if the patient had a diagnosis of schizophrenia. CONCLUSIONS Our analyses indicate that relatives' guilt proneness may be a determinant of their criticism, hostility and emotional overinvolvement towards a schizophrenic family member. This personality trait should be taken into account in family work which aims at modifying relatives' expressed emotion.