Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Retinal Image Shifts and Extra-Retinal Eye Movement Signals on Binocular Rivalry Alternations

Previous studies have indicated that saccadic eye movements correlate positively with perceptual alternations in binocular rivalry, presumably because the foveal image changes resulting from saccades, rather than the eye movement themselves, cause switches in awareness. Recently, however, we found evidence that retinal image shifts elicit so-called onset rivalry and not percept switches as such. These findings raise the interesting question whether onset rivalry may account for correlations between saccades and percept switches. We therefore studied binocular rivalry when subjects made eye movements across a visual stimulus and compared it with the rivalry in a ‘replay’ condition in which subjects maintained fixation while the same retinal displacements were reproduced by stimulus displacements on the screen. We used dichoptic random-dot motion stimuli viewed through a stereoscope, and measured eye and eyelid movements with scleral search-coils. Positive correlations between retinal image shifts and perceptual switches were observed for both saccades and stimulus jumps, but only for switches towards the subjects' preferred eye at stimulus onset. A similar asymmetry was observed for blink-induced stimulus interruptions. Moreover, for saccades, amplitude appeared crucial as the positive correlation persisted for small stimulus jumps, but not for small saccades (amplitudes < 1°). These findings corroborate our tenet that saccades elicit a form of onset rivalry, and that rivalry is modulated by extra-retinal eye movement signals.
Folate and Nutrients Involved in the 1-Carbon Cycle in the Pretreatment of Patients for Colorectal Cancer

To assess the ingestion of folate and nutrients involved in the 1-carbon cycle in non-treated patients with colorectal adenocarcinoma in a reference center for oncology in southeastern Brazil. In total, 195 new cases with colorectal adenocarcinoma completed a clinical evaluation questionnaire and a Food Frequency Questionnaire (FFQ). Blood samples from 161 patients were drawn for the assessment of serum folate. A moderate correlation was found between serum concentrations of folate, folate intake and the dietary folate equivalent (DFE) of synthetic supplements. Mulatto or black male patients with a primary educational level had a higher intake of dietary folate. Of patients obtaining folate from the diet alone or from dietary supplements, 11.00% and 0.10%, respectively, had intake below the recommended level. Of the patients using dietary supplements, 35% to 50% showed high levels of folic acid intake. There was a prevalence of inadequacy for vitamins B2, B6 and B12, ranging from 12.10% to 20.18%, while 13.76% to 22.55% of patients were likely to have adequate choline intake. The considerable percentage of patients with folate intake above the recommended levels deserves attention because of the harmful effects that this nutrient may have in the presence of established neoplastic lesions.
A Survey of Machine Translation: Its History, Current Status and Future Prospects

Elements of the history, state of the art, and probable future of Machine Translation (MT) are discussed. The treatment is largely tutorial, based on the assumption that this audience is, for the most part, ignorant of matters pertaining to translation in general, and MT in particular. The paper covers some of the major MT R&D groups, the general techniques they employ(ed), and the roles they play(ed) in the development of the field. The conclusions concern the seeming permanence of the translation problem, and potential re-integration of MT with mainstream Computational Linguistics.
Three Phase Coordinated Checkpointing Scheme for Mobile Distributed Systems

In this paper, a three phase minimum-process coordinated checkpointing algorithm for nondeterministic mobile distributed systems is proposed, where no useless checkpoints are taken. An effort has been made to minimize the blocking of processes and synchronization message overhead and to capture the partial transitive dependencies during the normal execution by piggybacking dependency vectors onto computation messages. Frequent aborts of checkpointing procedure may happen in mobile systems due to exhausted battery, non-voluntary disconnections of MHs, or poor wireless connectivity. Therefore, in the proposed scheme, all concerned MHs will take ad-hoc checkpoint only and these checkpoint is stored on the memory of MH only. In this case, if some process fails to take checkpoint in the first phase, then MHs need to abort their ad-hoc checkpoints only. In this way, we try to minimize the loss of checkpointing effort when any process fails to take its checkpoint in coordination with others. Keyword--Checkpointing, Ad-hoc checkpoint, Mobile Host, Mobile Support System
Further development of a model of chronic bone marrow aplasia in the busulphan‐treated mouse

Aplastic anaemia (AA) in man is an often fatal disease characterized by pancytopenia of the peripheral blood and aplasia of the bone marrow. AA is a toxic effect of many drugs and chemicals (e.g. chloramphenicol, azathioprine, phenylbutazone, gold salts, penicillamine and benzene). However, there are no widely used or convenient animal models of drug‐induced AA. Recently, we reported a new model of chronic bone marrow aplasia (CBMA = AA) in the busulphan (BU)‐treated mouse: eight doses of BU (10.50 mg/kg) were administered to female BALB/c mice over a period of 23 days; CBMA was evident at day 91/112 post‐dosing with significantly reduced erythrocytes, platelets, leucocytes and nucleated bone marrow cell counts. However, mortality was high (49.3%). We have now carried out a study to modify the BU‐dosing regime to induce CBMA without high mortality, and investigated the patterns of cellular responses in the blood and marrow in the post‐dosing period. Mice (n = 64/65) were dosed 10 times with BU at 0 (vehicle control), 8.25, 9.0 and 9.75 mg/kg over 21 days and autopsied at day 1, 23, 42, 71, 84, 106 and 127 post‐dosing (n = 7–15); blood and marrow samples were examined. BU induced a predictable bone marrow depression at day 1 post‐dosing; at day 23/42 post‐dosing, parameters were returning towards normal during a period of recovery. At day 71, 84, 106 and 127 post‐dosing, a stabilized, late‐stage, nondose‐related CBMA was evident in BU‐treated mice, with decreased erythrocytes, platelets and marrow cell counts, and increased MCV. At day 127 post‐dosing, five BU‐treated mice showed evidence of lymphoma. In this study, mortality was low, ranging from 3.1% (8.25 mg/kg BU) to 12.3% (9.75 mg/kg BU). It is concluded that BU at 9.0 mg/kg (or 9.25 mg/kg) is an appropriate dose level to administer (10 times over 21 days) to induce CBMA at approximately day 50–120 post‐dosing.
Predictors of Early and Late Enrollment in Cardiac Rehabilitation, Among Those Referred, After Acute Myocardial Infarction

Background— Cardiac rehabilitation (CR) after acute myocardial infarction (AMI) is a Class I recommendation. Although referral to CR after an AMI has recently become a performance measure, many patients may not participate. To illuminate potential barriers to participation, we examined the prevalence of, and patient-related factors associated with, CR participation within 1 and 6 months after an AMI. Methods and Results— We studied 2096 AMI patients enrolled from 19 US sites in the Prospective Registry Evaluating outcomes after Myocardial Infarction: Events and Recovery (PREMIER) registry. Analyses were limited to those patients referred for CR at the time of AMI hospitalization. A multivariable, conditional logistic regression model, stratified by hospital, was used to identify sociodemographic, comorbidity, and clinical factors independently associated with CR participation within 1 and 6 months of AMI hospital discharge. Only 29% (419/1450) and 48.25% (650/1347) of AMI patients who received referral for CR participated within 1 and 6 months after discharge, respectively. Women (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.44–0.86), uninsured (OR, 0.39; 95% CI, 0.21–0.71), and patients with hypertension (OR, 0.58; 95% CI, 0.43–0.78) and peripheral arterial disease (OR, 0.43; 95% CI, 0.22–0.85) were less likely to participate at 1 month. At 6 months after AMI, older patients (OR, 0.85 for each 10-year increment; 95% CI, 0.74–0.97), smokers (OR, 0.59; 95% CI, 0.44–0.80), and patients with economic burden (OR, 0.56; 95% CI, 0.38–0.81) were less likely to participate. Caucasians (OR, 1.73; 95% CI, 1.16–2.58) and educated patients (OR, 1.81; 95% CI, 1.42–2.30) were more likely to participate at 6 months. Patients with previous percutaneous interventions were less likely to participate at both 1 and 6 months post-AMI. Conclusions— Among patients referred for CR post-AMI, participation remains low both at 1 and 6 months after AMI. Because CR is associated with beneficial changes in cardiovascular risk factors and better outcomes after AMI, more aggressive efforts are needed to increase CR participation after referral.
Effects of Promoting Longer-Term and Exclusive Breastfeeding on Cardiometabolic Risk Factors at Age 11.5 Years: A Cluster-Randomized, Controlled Trial

Background— The duration and exclusivity of breastfeeding in infancy have been inversely associated with future cardiometabolic risk. We investigated the effects of an experimental intervention to promote increased duration of exclusive breastfeeding on cardiometabolic risk factors in childhood. Methods and Results— We followed-up children in the Promotion of Breastfeeding Intervention Trial, a cluster-randomized trial of a breastfeeding promotion intervention based on the World Health Organization/United Nations Children’s Fund Baby-Friendly Hospital Initiative. In 1996 to 1997, 17 046 breastfeeding mother-infant pairs were enrolled from 31 Belarusian maternity hospitals and affiliated polyclinics (16 intervention versus 15 control sites); 13 879 (81.4%) children were followed up at 11.5 years, with 13 616 (79.9%) who had fasted and did not have diabetes mellitus. The outcomes were blood pressure; fasting insulin, adiponectin, glucose, and apolipoprotein A1; and the presence of metabolic syndrome. Analysis was by intention to treat, accounting for clustering within hospitals/clinics. The intervention substantially increased breastfeeding duration and exclusivity in comparison with the control arm (43% versus 6% and 7.9% versus 0.6% exclusively breastfed at 3 and 6 months, respectively). Cluster-adjusted mean differences at 11.5 years between experimental versus control groups were as follows: 1.0 mm Hg (95% confidence interval, −1.1 to 3.1) for systolic and 0.8 mm Hg (−0.6 to 2.3) for diastolic blood pressure; −0.1 mmol/L (−0.2 to 0.1) for glucose; 8% (−3% to 34%) for insulin; −0.3 &mgr;g/mL (−1.5 to 0.9) for adiponectin; and 0.0 g/L (−0.1 to 0.1) for apolipoprotein A1. The cluster-adjusted odds ratio for metabolic syndrome, comparing experimental versus control groups, was 1.21 (0.85 to 1.72). Conclusions— An intervention to improve breastfeeding duration and exclusivity among healthy term infants did not influence cardiometabolic risk factors in childhood. Clinical Trial Registration— Current Controlled Trials: ISRCTN37687716 (http://www.controlled-trials.com/ISRCTN37687716). URL: http://clinicaltrials.gov. Unique identifier: NCT01561612.
Drivers of the Low-Cloud Response to Poleward Jet Shifts in the North Pacific in Observations and Models

The long-standing expectation that poleward shifts of the midlatitude jet under global warming will lead to poleward shifts of clouds and a positive radiative feedback on the climate system has been shown to be misguided by several recent studies. On interannual time scales, free-tropospheric clouds are observed to shift along with the jet, but low clouds increase across a broad expanse of the North Pacific Ocean basin, resulting in negligible changes in total cloud fraction and top-of-atmosphere radiation. Here it is shown that this low-cloud response is consistent across eight independent satellite-derived cloud products. Using multiple linear regression, it is demonstrated that the spatial pattern and magnitude of the low-cloud-coverage response is primarily driven by anomalous surface temperature advection. In the eastern North Pacific, anomalous cold advection by anomalous northerly surface winds enhances sensible and latent heat fluxes from the ocean into the boundary layer, resulting in large increases in low-cloud coverage. Local increases in low-level stability make a smaller contribution to this low-cloud increase. Despite closely capturing the observed response of large-scale meteorology to jet shifts, global climate models largely fail to capture the observed response of clouds and radiation to interannual jet shifts because they systematically underestimate how sensitive low clouds are to surface temperature advection, and to a lesser extent, low-level stability. More realistic model simulations of cloud–radiation–jet interactions require that parameterizations more accurately capture the sensitivity of low clouds to surface temperature advection.
A Lifecourse Model of Multimorbidity Resilience

The purpose of this article is to advance a Lifecourse Model of Multimorbidity Resilience. It focuses on the ways in which individuals face adversities associated with multimorbidity and regain a sense of wellness through a complex, dynamic phenomenon termed resilience. A comprehensive review of 112 publications (between 1995 and 2015) was conducted using several comprehensive electronic data bases. Two independent researchers extracted and synthesized resilience literature with specific applications to chronic illness. The article outlines five stages of theoretical development of resilience, synthesizes these with the aging and chronic illness literature, builds a rationale for a lifecourse approach to resilience, and applies the model to multimorbidity. Cultivating and maintaining resilience is fundamental to functioning and quality of life for those with multimorbidity. We found that there are a number of gaps in both basic and applied research that need to be filled to advance knowledge and practice based on resilience approaches.
MC1R‐dependent, melanin‐based colour polymorphism is associated with cell‐mediated response in the Eleonora’s falcon

Colour polymorphism in vertebrates is usually under genetic control and may be associated with variation in physiological traits. The melanocortin 1 receptor (Mc1r) has been involved repeatedly in melanin‐based pigmentation but it was thought to have few other physiological effects. However, recent pharmacological studies suggest that MC1R could regulate the aspects of immunity. We investigated whether variation at Mc1r underpins plumage colouration in the Eleonora’s falcon. We also examined whether nestlings of the different morphs differed in their inflammatory response induced by phytohemagglutinin (PHA). Variation in colouration was due to a deletion of four amino acids at the Mc1r gene. Cellular immune response was morph specific. In males, but not in females, dark nestling mounted a lower PHA response than pale ones. Although correlative, our results raise the neglected possibility that MC1R has pleiotropic effects, suggesting a potential role of immune capacity and pathogen pressure on the maintenance of colour polymorphism in this species.
HyPER: A runtime reconfigurable architecture for monte carlo option pricing in the Heston model

High-speed and energy-efficient computations are mandatory in the financial and insurance industry to survive in competition and meet the federal reporting requirements. On a hybrid CPU/FPGA system we propose a modular pricing engine and derive a novel algorithmic extension able to exploit online dynamic reconfiguration. The result is a high-performance and energy-efficient pricing system suitable for exotic option pricing in the state-of-the-art Heston market model. With the online reconfiguration extension our hybrid pricing system is nearly two orders of magnitude faster than high-end Intel CPUs, while consuming the same power.
Are Zero Tolerance Policies Effective in the Schools?

Although there can be no dispute that schools must do all that can be done to ensure the safety of learning environments, controversy has arisen about the use of zero tolerance policies and procedures to achieve those aims. In response to that controversy, and to assess the extent to which current practice benefits students and schools, the American Psychological Association convened a task force to evaluate the evidence and to make appropriate recommendations regarding zero tolerance policies and practices. An extensive review of the literature found that, despite a 20-year history of implementation, there are surprisingly few data that could directly test the assumptions of a zero tolerance approach to school discipline, and the data that are available tend to contradict those assumptions. Moreover, zero tolerance policies may negatively affect the relationship of education with juvenile justice and appear to conflict to some degree with current best knowledge concerning adolescent development. To address the needs of schools for discipline that can maintain school safety while maximizing student opportunity to learn, the report offers recommendations for both reforming zero tolerance where its implementation is necessary and for alternative practice to replace zero tolerance where a more appropriate approach is indicated.
Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A

Cutaneous leishmaniasis has various outcomes, ranging from self-healing reddened papules to extensive open ulcerations that metastasise to secondary sites and are often resistant to standard therapies. In the case of L. guyanensis (L.g), about 5–10% of all infections result in metastatic complications. We recently showed that a cytoplasmic virus within L.g parasites (LRV1) is able to act as a potent innate immunogen, worsening disease outcome in a murine model. In this study, we investigated the immunophenotype of human patients infected by L.g and found a significant association between the inflammatory cytokine IL-17A, the presence of LRV1 and disease chronicity. Further, IL-17A was inversely correlated to the protective cytokine IFN-γ. These findings were experimentally corroborated in our murine model, where IL-17A produced in LRV1+ L.g infection contributed to parasite virulence and dissemination in the absence of IFN-γ. Additionally, IL-17A inhibition in mice using digoxin or SR1001, showed therapeutic promise in limiting parasite virulence. Thus, this murine model of LRV1-dependent infectious metastasis validated markers of disease chronicity in humans and elucidated the immunologic mechanism for the dissemination of Leishmania parasites to secondary sites. Moreover, it confirms the prognostic value of LRV1 and IL-17A detection to prevent metastatic leishmaniasis in human patients.
Deep Spatial Feature Reconstruction for Partial Person Re-identification: Alignment-free Approach

Partial person re-identification (re-id) is a challenging problem, where only several partial observations (images) of people are available for matching. However, few studies have provided flexible solutions to identifying a person in an image containing arbitrary part of the body. In this paper, we propose a fast and accurate matching method to address this problem. The proposed method leverages Fully Convolutional Network (FCN) to generate fix-sized spatial feature maps such that pixel-level features are consistent. To match a pair of person images of different sizes, a novel method called Deep Spatial feature Reconstruction (DSR) is further developed to avoid explicit alignment. Specifically, DSR exploits the reconstructing error from popular dictionary learning models to calculate the similarity between different spatial feature maps. In that way, we expect that the proposed FCN can decrease the similarity of coupled images from different persons and increase that from the same person. Experimental results on two partial person datasets demonstrate the efficiency and effectiveness of the proposed method in comparison with several state-of-the-art partial person re-id approaches. Additionally, DSR achieves competitive results on a benchmark person dataset Market1501 with 83.58% Rank-1 accuracy.
The Art of Designing Robot Faces – Dimensions for Human-Robot Interaction

As robots enter everyday life and start to interact with ordinary people [5] the question of their appearance becomes increasingly important. A user’s perception of a robot can be strongly influenced by its facial appearance [6]. The dimensions and issues of face design are illustrated in the design rationale, details of construction and intended uses of a new minimal expressive robot called KASPAR.
Mycothiol Is Essential for Growth of Mycobacterium tuberculosis Erdman

ABSTRACT Mycothiol (MSH) is the major low-molecular-mass thiol in mycobacteria and is associated with the protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics. The biosynthesis of MSH is a multistep process, with the enzymatic reaction designated MshC being the ligase step in MSH production. A targeted disruption of the native mshC gene in M. tuberculosis Erdman produced no viable clones possessing either a disrupted mshC gene or reduced levels of MSH. However, when a second copy of the mshC gene was incorporated into the chromosome prior to the targeted disruption, multiple clones having the native gene disrupted and the second copy of mshC intact were obtained. These clones produced normal levels of MSH. These results demonstrate that the mshC gene and, more generally, the production of MSH are essential for the growth of M. tuberculosis Erdman under laboratory conditions.
Resistance of Nicotiana benthamiana to Phytophthora infestans Is Mediated by the Recognition of the Elicitor Protein INF1

Phytophthora infestans, the agent of potato and tomato late blight disease, produces a 10-kD extracellular protein, INF1 elicitin. INF1 induces a hypersensitive response in a restricted number of plants, particularly those of the genus Nicotiana. In virulence assays with different P. infestans isolates, five Nicotiana species displayed resistance responses. In all of the interactions, after inoculation with P. infestans zoospores, penetration of an epidermal cell was observed, followed by localized necrosis typical of a hypersensitive response. To determine whether INF1 functions as an avirulence factor in these interactions, we adopted a gene-silencing strategy to inhibit INF1 production. Several transformants deficient in inf1 mRNA and INF1 protein were obtained. These strains remained pathogenic on host plants. However, in contrast to the wild-type and control transformant strains, INF1-deficient strains induced disease lesions when inoculated on N. benthamiana. These results demonstrate that the elicitin INF1 functions as an avirulence factor in the interaction between N. benthamiana and P. infestans.