Miracle-dz/UniFAR-FTUs huggingface dataset:
Causes and Associated Features of Divorce as Seen by Recent Research

Abstract Most research conducted has come from the United States but a number of countries also provided information in connection with divorce and separation and thier causes. Little information is available, however, on how to deal with this problem effectively. Among the causes indicated are: women's independence; too early marriage; economic factors; poor intellectual, educational, and social skills; liberal divorce laws; sexual factors leading to incompatibility; role conflicts; alcoholism and substance abuse; risk-taking behavior; differences between the partners leading to acrimony; religious factors; attitudes to divorce and various other factors. The consequences of divorce are the diminishing of fathers' role in the family over recent years, the poor impact separation and divorce have on children, the emotional problems suffered by all concerned, and the reduced living standard of families that have separated.
The Pathophysiology of Skeletal Muscle Ischemia and the Reperfusion Syndrome: A Review

There are two components to the reperfusion syndrome, which follows extremity ischemia. The local response, which follows reperfusion. consists of limb swelling with its potential for aggravating tissue injury and the systemic response, which results in multiple organ failure and death. It is apparent that skeletal muscle is the predominant tissue in the limb but also the tissue that is most vulnerable to ischemia. Physiological and anatomical studies show that irreversible muscle cell damage starts after 3 h of ischemia and is nearly complete at 6 h. These muscle changes are paralleled by progressive microvascular damage. Microvascular changes appear to follow rather than precede skeletal muscle damage as the tolerance of capillaries to ischemia vary with the tissue being reperfused. The more severe the cellular damage the greater the microvascular changes and with death of tissue microvascular flow ceases within a few hours—the no reflow phenomenon. At this point tissue swelling ceases. The inflammatory responses following reperfusion varies greatly. When muscle tissue death is uniform, as would follow tourniquet ischemia or limb replantation, little inflammatory response results. In most instances of reperfusion, which follows thrombotic or embolic occlusion, there will be a variable degree of ischemic damage in the zone where collateral blood flow is possible. The extent of this region will determine the magnitude of the inflammatory response, whether local or systemic. Only in this region will therapy be of any benefit, whether fasciotomy to prevent pressure occlusion of the microcirculation, or anticoagulation to prevent further microvascular thrombosis. Since many of the inflammatory mediators are generated by the act of clotting, anticoagulation will have additional benefit by decreasing the inflammatory response. In instances in which the process involves the bulk of the lower extremity, amputation rather than attempts at revascularization may be the most prudent course to prevent the toxic product in the ischemic limb from entering the systemic circulation.
Stress and burnout in forensic psychiatric nursing

The relevant literature suggests that all branches of the nursing profession are subject to high levels of stress and burnout. Forensic psychiatric nursing has been considered as an area of high risk, despite a paucity of literature in this area, particularly in Australia. This paper presents the findings of a research study undertaken with forensic nurses (n = 51) and designed to measure their level of stress and burnout. The Maslach Burnout Inventory (MBI) and the Nursing Stress Scale (NSS) were the instruments used. The findings indicated that relatively few forensic nurses suffered from ‘high’ levels of burnout with considerably more forensic nurses recording ‘low’ levels of burnout. On the personal accomplishment subscale, only 17 per cent recorded a ‘high’ score. Interestingly the least reported stressor was lack of staff support for nursing activities which suggests that the amount of support received may account for lower than expected levels of stress. Copyright © 2003 John Wiley & Sons, Ltd.
Numerical counterparts of GRB host galaxies

We explore galaxy properties in general and properties of host galaxies of gammaray bursts (GRBs) in particular, using N-body/Eulerian hydrodynamic simulations and the stellar population synthesis model, Starburst99, to infer observable properties. We identify simulated galaxies that have optical star formation rate (SFR) and SFRto-luminosity ratio similar to those observed in a well-defined sample of ten host galaxies. Each of the numerical counterparts are found in catalogs at the same redshifts as the observed hosts. The counterparts are found to be low-mass galaxies, with low mass-to-light ratio, recent epoch of formation, and high ratio between the SFR and the average of the SFR. When compared to the overall galaxy population, they have colors much bluer than the high-mass star-forming galaxy population. Although their SFRs span a range of values, the specific rates of the numerical counterparts are equal to or higher than the median values estimated at the different redshifts. We also emphasize the strong relationships between the specific star formation rate (SFR) and quantities known to reflect the star formation history of galaxies, i.e. color and mass-to-light ratio: At intermediate redshift, the faintest and bluest galaxies are also the objects with the highest specific rates. These results suggest that GRB host galaxies are likely to be drawn from the high specific SFR sub-population of galaxies, rather than the high SFR galaxy population. Finally, as indicated by our catalogs, in an extended sample, the majority of GRB host galaxies is expected to have specific SFRs higher than found in the magnitude-limited sample studied here.
Semiclassical decay of near-extremal black holes

The decay of a near-extremal black hole down to the extremal state is studied in the background field approximation to determine the fate of injected matter and Hawking pairs. By examining the behavior of light rays and solutions to the wave equation it is concluded that the singularity at the origin is irrelevant. Furthermore, there is most likely an instability of the event horizon arising from the accumulation of injected matter and Hawking partners there. The possible role of this instability in reconciling the D-brane and black hole pictures of the decay process is discussed.
Impairment of slow inactivation as a common mechanism for periodic paralysis in DIIS4-S5

Background Mutations in the human skeletal muscle sodium channels are associated with hyperKPP, hypoKPP, paramyotonia congenita, and potassium-aggravated myotonia. This article describes the clinical manifestations of a patient with hyperKPP carrying a mutation (L689I) occurring in the linker DIIS4-S5 and its functional expression in a mammalian system. Objective To correlate the clinical manifestations of hyperkalemic periodic paralysis (hyperKPP) with the functional expression of a sodium channel mutation. Methods The mutation was introduced into a mammalian expression vector and expressed in the human embryonic kidney 293 cells. The functional expression of the L689I and that of the wild-type channels was monitored using the whole cell voltage-clamp technique. Results There was no change in the kinetics of fast inactivation, and inactivation curves were indistinguishable from that of wild-type channels. However, the L689I mutation caused a hyperpolarizing shift in the voltage dependence of activation and the mutant channels showed an impaired slow inactivation process. In addition, the mutant channels have a larger persistent current at −40 mV where window current may occur. Conclusions The L689I mutation has similar effects to the T704M mutation and causes hyperKPP in this family. Because both of these hyperKPP mutations cause episodic muscle weakness, and because patients harboring another mutation (I693T) also can have episodic weakness, it is hypothesized that mutations occurring in this region of the sodium channel may cause episodic weakness through an impaired slow inactivation process coupled with enhanced activation.
Vitamin D3 induces pro‐LL‐37 expression in myeloid precursors from patients with severe congenital neutropenia

The innate immune system produces a number of effector molecules that are important for protection against bacterial infections. Neutrophils and antimicrobial peptides are major components of innate defense with the capacity of rapid bacterial killing. Patients with severe congenital neutropenia (SCN) experience recurrent and chronic infections despite recombinant G‐CSF‐mobilized neutrophils. We have shown previously that these neutrophils are deficient in that they lack the antimicrobial peptide LL‐37. Here, we show that pro‐LL‐37 mRNA is not expressed in neutrophil precursors from patients with SCN, although the gene and promoter region for pro‐LL‐37, CAMP, does not display any mutations. The hormonal form of vitamin D3 [1,25(OH)2D3] induced the expression of pro‐LL‐37 in isolated neutrophil progenitors and in EBV‐transformed B cells from patients with SCN, whereas all‐trans retinoic acid only induced expression in transformed B cells. These results demonstrate that myeloid cells of patients with SCN can produce pro‐LL‐37, suggesting that other pathways are impaired.
Can Pay Regulation Kill? Panel Data Evidence on the Effect of Labor Markets on Hospital Performance

In many sectors, pay is regulated to be equal across heterogeneous geographical labor markets. When the competitive outside wage is higher than the regulated wage, there are likely to be falls in quality. We exploit panel data from the population of English hospitals in which regulated pay for nurses is essentially flat across the country. Higher outside wages significantly worsen hospital quality as measured by hospital deaths for emergency heart attacks. A 10 percent increase in the outside wage is associated with a 7 percent increase in death rates. Furthermore, the regulation increases aggregate death rates in the public health care system.
Bortezomib overcomes the negative prognostic impact of renal impairment in a newly diagnosed elderly patient with multiple myeloma: A case report

Multiple myeloma (MM) is a common B-cell hematological malignancy in the clinic. Bortezomib is the first-in-class proteasome inhibitor that has been approved for the treatment of patients with MM in the bone marrow. The present study report the case of an 83-year-old man who showed marked weakness, fatigue and a poor appetite. The patient was admitted to the Department of Nephrology due to severe renal impairment (RI). Immunofixation electrophoresis indicated a λ light chain-positive status. There were 19.2% plasmablasts and proplasmacytes in the bone marrow. Positivity for the cell surface markers cluster of differentiation (CD)13, CD33, CD38 and human leukocyte antigen-antigen D-related was detected by flow cytometry. The patient was diagnosed with MM, λ light chain type, stage IIIB, and received bortezomib and dexamethasone regimen chemotherapy. RI was improved following the chemotherapy, and plasmablasts and proplasmacytes were almost eliminated. The Hb level was maintained at ~90 g/l. Overall, the present case report suggests that bortezomib may be safe and effective for elderly patients, even those >80 years of age, with severe RI.
Transgenic zebrafish expressing green fluorescent protein in dopaminergic neurons of the ventral diencephalon

We have generated a line of transgenic zebrafish, Tg(dat:EGFP), in which the green fluorescent protein (GFP) is expressed under the control of cis‐regulatory elements of the dopamine transporter (dat) gene. In Tg(dat:EGFP) fish, dopamine (DA) neurons are labeled with GFP, including those in ventral diencephalon (vDC) clusters, amacrine cells in the retina, in the olfactory bulb, in the pretectum, and in the caudal hypothalamus. In the vDC, DA neurons of groups 2–6 are correctly labeled with GFP, based on colocalization analyses. MPTP (1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine) treatments induced a modest but significant loss of DA neurons in groups 2–6 of the vDC. This transgenic line will be useful for the study of DA neuron development and in models of DA neuron loss. Developmental Dynamics 240:2539–2547, 2011. © 2011 Wiley‐Liss, Inc.
A language for information flow: dynamic tracking in multiple interdependent dimensions

This paper presents <i>λ<sub>I</sub></i>, a language for dynamic tracking of information flow across multiple, interdependent dimensions of information. Typical dimensions of interest are integrity and confidentiality. <i>λ<sub>I</sub></i> supports arbitrary domain-specific policies that can be developed independently. <i>λ<sub>I</sub></i> treats information-flow metadata as a first-class entity and tracks information flow on the metadata itself (integrity on integrity, integrity on confidentiality, etc.). This paper also introduces IMPOLITE, a novel class of information-flow policies for <i>λ<sub>I</sub></i>. Unlike many systems, which only allow for absolute-security relations, IMPOLITE can model more realistic security policies based on relative-security relations. IMPOLITE demonstrates how policies on interdependent dimensions of information can be simultaneously enforced within <i>λ<sub>I</sub></i>'s unified framework.
Improving fourth-grade students' composition skills: Effects of strategy instruction and self-regulation procedures

Extending S. Graham and K. R. Harris's (2003) self-regulated strategy development model, this study examined whether self-regulation procedures would increase the effectiveness of a writing strategies training designed to improve 4th graders' (N = 113) composition skills. Students who were taught composition strategies in conjunction with self-regulation procedures were compared with (a) students who were taught the same strategies but received no instruction in self-regulation and (b) students who received didactic lessons in composition. Both at posttest and at maintenance (5 weeks after the instruction), strategy plus self-regulation students wrote more complete and qualitatively better stories than students in the 2 comparison conditions. They also displayed superior performance at a transfer task requiring students to recall essential parts of an orally presented story.
Stereological study of pyramidal neurons in the human superior temporal gyrus from childhood to adulthood

The association cortex of the superior temporal gyrus (STG) is implicated in complex social and linguistic functions. Thus, reliable methods for quantifying cellular variation in this region could greatly benefit researchers interested in addressing the cellular correlates of typical and atypical function associated with these critical cognitive abilities. To facilitate this task, we first present a general set of cytoarchitectonic criteria targeted specifically toward stereological analyses of thick, Nissl‐stained sections for the homotypical cortex of the STG, referred to here as BA22/TA. Second, we use the optical fractionator to estimate pyramidal neuron number and the nucleator for pyramidal somal and nuclear volume. We also investigated the influence of age and sex on these parameters, as well as set a typically developing baseline for future comparisons.
The characteristics of electromigration and thermomigration in flip chip solder joints

Electromigration and thermomigration behaviors of eutectic tin-lead solder joints were studied above 100 degC with the currents ranging from 1.6 A to 2.0 A. The local temperature of the chip was deducted according to temperature coefficient of resistance. Also, this temperature was inspected by a thermal infrared mapping technique. It is suggested that the heat accumulation within first-level solder interconnections was highly related to the current density. During the electromigration process, Pb migration was apparently visible because of its faster diffusivity. Meanwhile, voids were initiated at the entry location of the electron flow due to the current crowding effect. Numerical simulation also predicted a local current density of above 105 A/cm2 within the solder joint In the thermomigration process, the transport of Pb was detected owing to the thermal gradient across the solder joint. Voids also occurred at the contact window due to accelerated atomic diffusion. In addition, the effect of electromigration and thermomigration on the mechanical behavior of the solder joint was examined through shearing tests.
Discrete Gravity Models and Loop Quantum Gravity: a Short Review

We review the relation between Loop Quantum Gravity on a fixed graph and discrete models of gravity. We compare Regge and twisted geometries, and discuss discrete actions based on twisted geometries and on the discretization of the Plebanski action. We discuss the role of discrete geometries in the spin foam formalism, with particular attention to the definition of the simplicity constraints.
Central processing of rectal pain: a functional MR imaging study.

BACKGROUND AND PURPOSE Although the central processing of somatic pain has been dealt with in numerous brain imaging studies, the neural correlates of visceral pain have received much more limited attention. Our goal was to assess the feasibility of detecting brain activation patterns induced by rectal pain by means of functional MR imaging. We hypothesized that the cerebral processing of rectal pain would exhibit strong similarities with the central processing of somatic pain. METHODS Functional MR imaging data were obtained from eight healthy subjects. A block paradigm was applied. Rectal pain was induced by inflating a latex balloon catheter that had been inserted into the rectum. Functional responses were established by means of cross-correlation analysis. RESULTS Activation was detected within the anterior cingulate gyrus, the prefrontal cortex, the insular cortex, the sensory-motor cortex, the inferior parietal lobule, the posterior cingulate gyrus, and the visual cortex. CONCLUSION Functional MR imaging of visceral pain is feasible in healthy subjects. The activation patterns observed in this study support the hypothesis that the cerebral processing of visceral pain involves multiple components, similar to the central processing of somatic pain. Our results constitute a first step toward the identification of possible aberrations in the activation patterns of patients suffering from visceral hypersensitivity.
Ozone exposure and systemic biomarkers: Evaluation of evidence for adverse cardiovascular health impacts

Abstract The US Environmental Protection Agency (EPA) recently concluded that there is likely to be a causal relationship between short-term (< 30 days) ozone exposure and cardiovascular (CV) effects; however, biological mechanisms to link transient effects with chronic cardiovascular disease (CVD) have not been established. Some studies assessed changes in circulating levels of biomarkers associated with inflammation, oxidative stress, coagulation, vasoreactivity, lipidology, and glucose metabolism after ozone exposure to elucidate a biological mechanism. We conducted a weight-of-evidence (WoE) analysis to determine if there is evidence supporting an association between changes in these biomarkers and short-term ozone exposure that would indicate a biological mechanism for CVD below the ozone National Ambient Air Quality Standard (NAAQS) of 75 parts per billion (ppb). Epidemiology findings were mixed for all biomarker categories, with only a few studies reporting statistically significant changes and with no consistency in the direction of the reported effects. Controlled human exposure studies of 2 to 5 hours conducted at ozone concentrations above 75 ppb reported small elevations in biomarkers for inflammation and oxidative stress that were of uncertain clinical relevance. Experimental animal studies reported more consistent results among certain biomarkers, although these were also conducted at ozone exposures well above 75 ppb and provided limited information on ozone exposure-response relationships. Overall, the current WoE does not provide a convincing case for a causal relationship between short-term ozone exposure below the NAAQS and adverse changes in levels of biomarkers within and across categories, but, because of study limitations, they cannot not provide definitive evidence of a lack of causation.
Alcoholism, brief intervention and the institutional context: a focus-group study with French and Finnish general practitioners

The moral problem of heavy drinking has become medicalised. However, when taking into account the different levels of medicalisation, French alcohol policy and treatment organisation has traditionally gone further than Finnish policy, although physicians in both countries are now becoming more important in the treatment of alcoholism. General practitioners (GPs) are often the first to diagnose alcoholism and they are expected to apply brief interventions, which have been proven effective in reducing heavy alcohol consumption. Focus-group interviews were conducted in Finland and France using three film clips as a stimulus for discussion. The short vignettes show incidences of alcohol problems from scenes in international fictional movies, with themes of loss of control, harm of loved ones and cue dependency. Interviews were analysed for GPs’ narratives about alcohol problems and alcoholism, using the semiotic concept of focalisation. The influence of historical approaches to alcohol problems was evident in the French GPs’ focus on the suffering of the alcoholic in comparison with the Finnish GPs’ emphasis on the alcoholic's family misery and their obligation only in caring for the physical problems of the alcoholic. The organisation of primary health care is identified as one important factor for these differences in conceptualising heavy drinking. Implications are that the compatibility of brief interventions with institutional and cultural contexts of health care should be considered before implementation.