Miracle-dz/UniFAR-FTUs huggingface dataset:
Systematic Screenings to Prevent the Development of Learning and Behavior Problems: Considerations for Practitioners, Researchers, and Policy Makers

In this article, we discuss the importance of systematic screenings to monitor K—12 students’ behavioral and academic performance, with an emphasis on the need to identify and support students with emotional and behavioral disorders before they develop significant learning and behavior problems requiring special education services under the category of emotional disturbances. We emphasize the importance of conducting systematic screenings across the K—12 grade span within the context of comprehensive, integrated, three-tiered models of prevention. We provide brief descriptions of some of the current tools available to assess academic and behavioral performance patterns over time and present a balanced discussion of the benefits and challenges associated with the screening. Specifically, we describe how these measures can be used to (a) assess overall levels of performance within and across the school years and (b) identify students who may require secondary and tertiary levels of prevention beyond primary prevention efforts. We conclude with responsibilities that come with conducting screenings, with specific considerations for practitioners, researchers, and policy makers.
Origins of Religiousness: The Role of Natural Disasters

Across 800 regions of the World, this research shows that people are more religious when living in regions that are more frequently razed by natural disasters. This is in line with psychological theory stressing that religious people tend to cope with adverse life events by seeking comfort in their religion or searching for a reason for the event; for instance that the event was an act of God. This is termed religious coping. Natural disasters are a source for adverse life events, and thus one way to interpret my findings is by way of religious coping. The results are robust to various measures of religiousness, and to inclusion of country fixed effects, income, education, demographics, religious denominations, and other climatic and geographic features. The results hold within Christianity, Islam and Buddhism, and across continents. To eliminate bias from omitted variables and selection (perhaps religious people are less likely to move out of disaster areas as they see the disaster as an act of God), I further show that second generation immigrants whose mothers descend from natural disaster areas, are more religious than their counterparts with ancestors from calmer areas. Why should economists care? Evidence suggests that religiousness influences economic outcomes (e.g., McCleary & Barro (2003), Iannaccone (1998)).
Age-Related Changes in Frontal and Temporal Lobe Volumes in Men

Methods: Seventy healthy adult men aged 19 to 76 years underwent magnetic resonance imaging. Coronal images focused on the frontal and temporal lobes were acquired using pulse sequences that maximized gray vs white matter contrast. The volumes of total frontal and temporal lobes as well as the gray and white matter subcomponents were evaluated. Results: Age-related linear loss in gray matter volume in both frontal (r=˛0.62, P,.001) and temporal (r=˛0.48, P,.001) lobes was confirmed. However, the quadratic function best represented the relationship between age and white matter volume in the frontal (P,.001) and temporal (P,.001) lobes. Secondary analyses indicated that white matter volume increased until age 44 years for the frontal lobes and age 47 years for the temporal lobes and then declined. Conclusions: The changes in white matter suggest that the adult brain is in a constant state of change roughly defined as periods of maturation continuing into the fifth decade of life followed by degeneration. Pathological states that interfere with such maturational processes could result in neurodevelopmental arrests in adulthood. Arch Gen Psychiatry. 2001;58:461-465
G6PD Deficiency Does Not Enhance Susceptibility for Acquiring Helicobacter pylori Infection in Sardinian Patients

Background Subjects with glucose-6-phosphate dehydrogenase (G6PD) deficiency may be more susceptible to infections due to impaired leukocyte bactericidal activity. The disorder is common in the Mediterranean area. The aim of this study was to investigate whether G6PD deficiency may be a risk factor for acquiring H. pylori infection. Methods We performed a retrospective study. Data from clinical records of 6565 patients (2278 men and 4287 women, median age 51, range 7‒94) who underwent upper endoscopy between 2002 and 2014 were collected. H. pylori status, assessed by histology plus rapid urease test or 13C-urea breath test, and G6PD status were also reported. A multiple logistic regression model was used to investigate the association between G6PD deficiency and H. pylori infection. Results Enzyme deficiency was detected in 12% (789/6565) of the entire cohort, and more specifically in 8.3% of men and in 14.0% of women. Overall, the proportion of patients positive for H. pylori was 50.6% and 51.5% among G6PD deficient and non-deficient patients (χ² = 0.271; p = 0.315). Moreover, among G6PD-deficient and normal patients the frequency of previous H. pylori infection was similar. After adjustment for age and gender the risk for acquiring H. pylori infection was similar in G6PD-deficient and normal patients. Only age was a strong statistically significant risk predictor. Conclusions These results demonstrate for the first time that G6PD deficiency does not enhance patients’ susceptibility to acquire H. pylori infection in Sardinia.
FTY720 reduces T-cell recruitment into murine intestinal allograft and prevents activation of graft-infiltrating cells

Background. Effective immunosuppression is a critical determinant of graft survival in small-bowel transplantation (SBTx). The present study was designed to determine the potency of FTY720, a newly synthesized immunosuppressant, in rat SBTx and examine the phenotype of graft-infiltrating cells to evaluate its effect on intestinal allografts. Materials and Methods. A segment of intestine of Dark Agouti rats was transplanted heterotopically into Lewis rats. The recipients were treated with or without oral FTY720 at a dose of 1 mg/kg per day. Six days after surgery, peripheral blood lymphocytes and lymphocytes from the mesenteric lymph nodes, Peyer’s patches, intraepithelial site, and lamina propria of the intestinal allograft were isolated. After the number of lymphocytes in each site was counted, the lymphocyte subpopulations in the intestinal allograft were evaluated by means of a FACScan flow cytometer using several monoclonal antibodies. Results. FTY720 treatment significantly prolonged recipient survival and strongly inhibited rejection histologically in comparison with control rats. FTY720 immunosuppression resulted in a marked reduction of lymphocyte number in the graft epithelium and lamina propria and the proportion of CD8+ and CD25+ cells. FTY720 also significantly decreased T-cell receptors and increased B cells in the graft Peyer’s patches. Conclusion. FTY720 promoted long-term SBTx recipient survival and maintained the architecture of intestinal allografts. FTY720 immunosuppression may be associated with a reduction of T-cell recruitment subsequent to the redistribution of lymphocyte subpopulations to control the proliferation and activation of graft-infiltrating cells in intestinal allografts.
The Quality of Students' Use of Evidence in Written Scientific Explanations

Drawing on sociological and philosophical studies of science, science educators have begun to view argumentation as a central scientific practice that students should learn. In this article, we extend recent work to understand the structure of students' arguments to include judgments about their quality through content analyses of high school students' written explanations for 2 problems of natural selection. In these analyses, we aim to explicate the relations between students' conceptual understanding of specific domains and their epistemic understanding of scientific practices of argumentation as they try to learn science through inquiry. We present a method that assesses the warrant of explanatory claims, the sufficiency of the evidence explicitly cited for claims, and students' rhetorical use of specific inscriptions in their arguments. Students were attentive to the need to cite data, yet they often failed to cite sufficient evidence for claims. Students' references to specific inscriptions in their arguments often failed to articulate how specific data related to particular claims. We discuss these patterns of data citation in terms of what they suggest about students' epistemological ideas about explanation and consequent implications for inquiry-oriented, science education reforms.
Community, Citizenship, and the third Way

This article analyses recent debates about the Third Way in politics in Britain and the United States. It suggests that what is most significant is the emergence of a new politics of conduct that seeks to reconstruct citizens as moral subjects of responsible communities. The author considers the presuppositions of such a politics and its implications for technologies of government.
Feasibility of using tissue microarray cores of paraffin-embedded breast cancer tissue for measurement of gene expression: a proof-of-concept study

Aims To determine whether 0.6 mm cores of formalin-fixed paraffin-embedded (FFPE) tissue, as commonly used to construct immunohistochemical tissue microarrays, may be a valid alternative to tissue sections as source material for quantitative real-time PCR-based transcriptional profiling of breast cancer. Methods Four matched 0.6 mm cores of invasive breast tumour and two 10 μm whole sections were taken from eight FFPE blocks. RNA was extracted and reverse transcribed, and TaqMan® assays were performed on the 21 genes of the Oncotype DX® Breast Cancer assay. Expression of the 16 recurrence-related genes was normalised to the set of five reference genes, and the recurrence score (RS) was calculated. Results RNA yield was lower from 0.6 mm cores than from 10 μm whole sections, but was still more than sufficient to perform the assay. RS and single gene data from cores were highly comparable with those from whole sections (RS p=0.005). Greater variability was seen between cores than between sections. Conclusions FFPE sections are preferable to 0.6 mm cores for RNA profiling in order to maximise RNA yield and to allow for standard histopathological assessment. However, 0.6 mm cores are sufficient and would be appropriate to use for large cohort studies.
Older Caregiving Parents: Division of Household Labor, Marital Satisfaction, and Caregiver Burden*

Based on a sample of 126 families, this study investigated how division of household labor is related to marital satisfaction and caregiving burden among older married parents caring for adult children with intellectual disabilities. For mothers, greater spousal participation in household work and satisfaction with the division of labor were positively related to marital satisfaction. Satisfaction with division of labor also appeared to buffer maternal caregiving stress, decreasing the relationship between behavior problems of the adult child and caregiver burden. For fathers, there was no relationship between division of household labor and marital satisfaction. Behavior problems of the adult child predicted paternal caregiving burden only when men were satisfied with the labor division. Practice implications for professionals working with older caregiving parents are discussed.
Natural infection of murine norovirus in conventional and specific pathogen-free laboratory mice

Noroviruses cause most cases of acute viral gastroenteritis worldwide. The lack of a cell culture infection model for human norovirus necessitates the use of molecular methods and/or viral surrogate models amenable to cell culture to predict norovirus inactivation. Murine norovirus (MNV) may be used to construct a small animal model for studying the biology and pathogenesis of noroviruses because MNV is the only norovirus that replicates in cell culture and a small animal model. However, recent studies have shown that natural MNV infection is widespread in laboratory mouse colonies. We investigated MNV infection in both conventional and specific pathogen-free (SPF) genetically modified mice from Japan and the US, and commercial mice from several animal breeders in Japan, using serological and molecular techniques. MNV antibodies were detected in 67.3% of conventional mice and 39.1% of SPF mice from Japan and 62.5% of conventional mice from the US. MNV antibodies were also found in 20% of commercial SPF C57BL/6 mice from one of three breeders. Partial gene amplification of fecal isolates from infected animals showed that the isolates were homologous to reported MNV sequences. These results suggest that both conventional and SPF laboratory mice, including commercial mice, are widely infected with MNV, which might require considerable attention as an animal model of human disease.
Colorful Niches of Phytoplankton Shaped by the Spatial Connectivity in a Large River Ecosystem: A Riverscape Perspective

Large rivers represent a significant component of inland waters and are considered sentinels and integrators of terrestrial and atmospheric processes. They represent hotspots for the transport and processing of organic and inorganic material from the surrounding landscape, which ultimately impacts the bio-optical properties and food webs of the rivers. In large rivers, hydraulic connectivity operates as a major forcing variable to structure the functioning of the riverscape, and–despite increasing interest in large-river studies–riverscape structural properties, such as the underwater spectral regime, and their impact on autotrophic ecological processes remain poorly studied. Here we used the St. Lawrence River to identify the mechanisms structuring the underwater spectral environment and their consequences on pico- and nanophytoplankton communities, which are good biological tracers of environmental changes. Our results, obtained from a 450 km sampling transect, demonstrate that tributaries exert a profound impact on the receiving river’s photosynthetic potential. This occurs mainly through injection of chromophoric dissolved organic matter (CDOM) and non-algal material (tripton). CDOM and tripton in the water column selectively absorbed wavelengths in a gradient from blue to red, and the resulting underwater light climate was in turn a strong driver of the phytoplankton community structure (prokaryote/eukaryote relative and absolute abundances) at scales of many kilometers from the tributary confluence. Our results conclusively demonstrate the proximal impact of watershed properties on underwater spectral composition in a highly dynamic river environment characterized by unique structuring properties such as high directional connectivity, numerous sources and forms of carbon, and a rapidly varying hydrodynamic regime. We surmise that the underwater spectral composition represents a key integrating and structural property of large, heterogeneous river ecosystems and a promising tool to study autotrophic functional properties. It confirms the usefulness of using the riverscape approach to study large-river ecosystems and initiate comparison along latitudinal gradients.
Eccentric/concentric ratios at selected velocities for the invertor and evertor muscles of the chronically unstable ankle.

OBJECTIVE: The use of muscle balancing by the clinician to determine return to activity or discharge of a patient is not a well understood measure. Because of the lack of information on the poorly understood concept of eccentric/concentric (E/C) ratios at the ankle, the purpose was to determine the E/C ratios for the invertor and evertor muscles at various velocities in healthy and chronically unstable ankles. METHODS: Ten subjects with healthy ankles and 14 with chronically unstable ankles performed five maximal effort reciprocal eccentric/contraction contractions on an isokinetic dynamometer at four velocities (60, 120, 180, and 240 degrees/s) and for each physiological movement of inversion and eversion. Data were analysed using a two way mixed model analysis of variance with repeated measures, with Tukey's test used for post hoc analysis. RESULTS: Although the chronically unstable ankle was significantly weaker (p < 0.05) eccentrically and concentrically for inversion and eversion, the main effect of the E/C ratios for the ankle was not significant for either joint motion. The main effect of velocity was significant (p < 0.05) for each joint motion, but no significant interaction effects were observed. As velocity increased, the E/C ratio increased, except at 180 and 240 degrees/s for either ankle group. CONCLUSIONS: Chronic ankle instability and muscle weakness co-exist. Adequate E/C ratios in the chronically unstable ankle may exist in the absence of normal strength values.
A Path Toward Fairness

Recent experimental findings on behavioral games show that subjects do not behave in a self-interest-maximizing manner as would be predicted by game theory. An evolutionary approach attempts to explain why 'irrational' strategies can be dominant in the long run. The article presents an evolutionary model of the Ultimatum game by considering the impact of interaction structure. The question of interest is: will the dominant strategy in evolution be different from the Nash-equilibrium strategy if players are allowed to choose partners they prefer based on the reinforcements (payoffs) from past interactions? Numerical simulation shows that the strategies of fairness could evolve to be dominant. Conditions of the emergence and its properties are discussed. The model offers a supplementary theoretical account for recent field work that indicates a positive association between market integration and the likelihood of making fair offers in the Ultimatum game (Henrich et al. 2004).
Urodynamic assessment of bladder and urethral function among men with lower urinary tract symptoms after radical prostatectomy: A comparison between men with and without urinary incontinence

Purpose We compared bladder and urethral functions following radical prostatectomy (RP) between men with and without urinary incontinence (UI), using a large-scale database from SNU-experts-of-urodynamics-leading (SEOUL) Study Group. Materials and Methods Since July 2004, we have prospectively collected data on urodynamics from 303 patients with lower urinary tract symptoms (LUTS) following RP at three affiliated hospitals of SEOUL Study Group. After excluding 35 patients with neurogenic abnormality, pelvic irradiation after surgery, or a history of surgery on the lower urinary tract, 268 men were evaluated. We compared the urodynamic findings between men who had LUTS with UI (postprostatectomy incontinence [PPI] group) and those who had LUTS without UI (non-PPI group). Results The mean age at an urodynamic study was 68.2 years. Overall, a reduced bladder compliance (≤20 mL/cmH2O) was shown in 27.2% of patients; and 31.3% patients had idiopathic detrusor overactivity. The patients in the PPI group were older (p=0.001) at an urodynamic study and had a lower maximum urethral closure pressure (MUCP) (p<0.001), as compared with those in the non-PPI group. Bladder capacity and detrusor pressure during voiding were also significantly lower in the PPI group. In the logistic regression, only MUCP and maximum cystometric capacity were identified as the related factor with the presence of PPI. Conclusions In our study, significant number of patients with LUTS following RP showed a reduced bladder compliance and detrusor overactivity. PPI is associated with both impairment of the urethral closuring mechanism and bladder storage dysfunction.
The Effects of Cancer-Related Pain and Fatigue on Functioning of Older Adult, Long-term Cancer Survivors

This research examines the fatigue and pain reported by a sample of long-term (5 years), older adult (≥60 years) survivors of breast, prostate, and colorectal cancer. It also examines the importance of cancer and age-related factors as correlates of pain and fatigue as well as the relationship between pain and fatigue and functional difficulty. Data were derived from 321 in-person interviews with a sample of survivors randomly selected from a tumor registry at a comprehensive cancer center. The results of multivariate analysis indicate that the pain, energy level, and weakness reported by older adult cancer survivors are more strongly related to age-related factors than they are to cancer-related factors. Age-related factors accounted for 14% of the variance in pain compared with 2% for cancer-related factors. For energy level, age-related factors explained 4% of the variance, whereas cancer-related factors account for 2%. Age-related factors accounted for 9% of the variance in weakness compared with 6% for cancer-related factors. Furthermore, pain, energy, and weakness are all statistically significant predictors of functional difficulties (β = .20, −.16, and .11, respectively). Age-related factors explained 21% of the total variance, whereas cancer-related factors contributed 6%. This research points to the fact that both cancer and age-related factors contribute to the pain and fatigue of older adult survivors, although factors such as comorbidites and noncancer symptoms appear to be relatively more important. Because it is not unusual for those providing health care to older adults to be unaware of their cancer history and treatments, the role that cancer may play in symptoms such pain and fatigue may go unassessed and unaddressed.
Race, Cultural Capital, and Educational Resources: Persistent Inequalities and Achievement Returns.

Theories of cultural capital and family educational resources explain how and why background matters for achievement, yet it is unclear whether the processes described are equally applicable to nonwhites. The study presented here examined (1) the extent to which black and white students differ in cultural capital and educational resources, (2) the mediating role these attributes may play between family background and racial disparities in achievement, and (3) whether educational returns vary by racial group. The findings suggest that significant racial variations in cultural capital and household educational items are largely a function of disparities in family socioeconomic status, but that these resources have only a small mediating effect on the gap in black-white achievement. Black and low-SES students tend to receive less educational return, probably because of micropolitical evaluative processes at the school and classroom levels
Externalities of Corporate Tax Avoidance

We show that when a meaningful proportion of firms in an economy engage in tax avoidance strategies, the covariance between a firm’s cash flow and the market cash flows increases, thereby increasing a firm’s cost of capital. This negative externality is imposed on all firms in the economy, not just tax-avoiding firms. The negative externality results regardless of the level of uncertainty associated with the tax avoidance; however, tax avoidance with more uncertain outcomes exacerbates the effect. The negative externality is most burdensome on firms that do not engage in tax avoidance because these firms do not benefit from the increase in after-tax cash flow that is associated with tax avoidance. Our results should be of interest to policy makers who are analyzing the costs associated with tax avoidance and strategies to curb it as well as to empirical researchers examining the relation between cost of capital and tax avoidance.