Miracle-dz/UniFAR-FTUs huggingface dataset:
Cutaneous polyamines in psoriasis

The polyamines putrescine, spermidine and spermine are intimately associated with cellular growth and division. Previous studies ofthe polyamines and their rate limiting biosynthetic enzyme, ornithine decarboxylase, in psoriasis have shown significant changes compared with non‐psoriatic skin. We have further studied cutaneous polyamines in patients with psoriasis and in normal subjects. Epidermal shave biopsies were taken and assayed for ornithine decarboxylase activity and polyamine levels. Psoriasis lesions showed increased ornithine decarboxylase activity compared with vminvolved skin. The levels of ornithine decarboxylase activity in uninvolved psoriasis skin were also higher than in normals. There was increased putrescine in involved psoriasis compared with uninvolved and normal skin. Spermidine and spermine were increased in psoriasis skin and in vminvolved skin and compared with normals. The spermidine/spermine ratio was greatest in involved skin compared with uninvolved and normal.
Simulation and implementation of improved chaotic Colpitts circuit for UWB communications

In this paper, we develop an improved chaotic Colpitts oscillator applied to ultra wide band wireless communication system. We design, simulate and implement the improved chaotic Colpitts oscillator using Philip's wideband transistor BJT BFG425W. The numerical simulation using Matlab and circuit simulation using Advanced Design System (ADS) are also presented. The oscillator is designed based on micro-strip substrate and the simulation result of the layout approves the possibility for UWB wireless communication applications.
Attention network functioning in children with anxiety disorders, attention-deficit/hyperactivity disorder and non-clinical anxiety

Background Research with adults suggests that anxiety is associated with poor control of executive attention. However, in children, it is unclear (a) whether anxiety disorders and non-clinical anxiety are associated with deficits in executive attention, (b) whether such deficits are specific to anxiety versus other psychiatric disorders, and (c) whether there is heterogeneity among anxiety disorders (in particular, specific phobia versus other anxiety disorders). Method We examined executive attention in 860 children classified into three groups: anxiety disorders (n = 67), attention-deficit/hyperactivity disorder (ADHD; n = 67) and no psychiatric disorder (n = 726). Anxiety disorders were subdivided into: anxiety disorders excluding specific phobia (n = 43) and specific phobia (n = 21). The Attention Network Task was used to assess executive attention, alerting and orienting. Results Findings indicated heterogeneity among anxiety disorders, as children with anxiety disorders (excluding specific phobia) showed impaired executive attention, compared with disorder-free children, whereas children with specific phobia showed no executive attention deficit. Among disorder-free children, executive attention was less efficient in those with high, relative to low, levels of anxiety. There were no anxiety-related deficits in orienting or alerting. Children with ADHD not only had poorer executive attention than disorder-free children, but also higher orienting scores, less accurate responses and more variable response times. Conclusions Impaired executive attention in children (reflected by difficulty inhibiting processing of task-irrelevant information) was not fully explained by general psychopathology, but instead showed specific associations with anxiety disorders (other than specific phobia) and ADHD, as well as with high levels of anxiety symptoms in disorder-free children.
Ecological specialization of the aphid Aphis gossypii Glover on cultivated host plants

Many plant‐feeding insect species considered to be polyphagous are in fact composed of genetically differentiated sympatric populations that use different hosts and between which gene flow still exists. We studied the population genetic structure of the cotton‐melon aphid Aphis gossypii that is considered as one of the most polyphagous aphid species. We used eight microsatellites to analyse the genetic diversity of numerous samples of A. gossypii collected over several years at a large geographical scale on annual crops from different plant families. The number of multilocus genotypes detected was extremely low and the genotypes were found to be associated with host plants. Five host races were unambiguously identified (Cucurbitaceae, cotton, eggplant, potato and chili‐ or sweet pepper). These host races were dominated by asexual clones. Plant transfer experiments using several specialized clones further confirmed the existence of host‐associated trade‐offs. Finally, both genetic and experimental data suggested that plants of the genus Hibiscus may be used as refuge for the specialized clones. Resource abundance is discussed as a key factor involved in the process of ecological specialization in A. gossypii.
Emergence of communication and language in evolving robots

Modeling the evolution of communication and language is one of the most fascinating and challenging problems in science. Progressing toward this ambitious goal implies explaining how simple communication forms emerged in the first place and how they evolved into structured communication systems with the characteristics of human language. In this chapter, we will illustrate how communication systems originate and evolve in a population of robots that adapt to a given task/environment. The analysis of these synthetic experiments can help us to understand: (i) how communication can emerge in a population of initially noncommunicating individuals, (ii) what conditions represent a prerequisite for the emergence of a robust and stable communication system, (iii) how the communication system changes by eventually increasing in complexity, and (iv) how signals and meanings originate and how they are grounded in robots’ sensorimotor states.
Volumetric and scintigraphic changes following endoscopic lung volume reduction

Bronchoscopic treatment of emphysema represents an emerging therapeutic modality for advanced emphysematous lung destruction in chronic obstructive pulmonary disease (COPD). Within the proposed techniques for endoscopic lung volume reduction (ELVR), a significant amount of experience exists for the placement of endobronchial valves (EBV) (Zephyr® valves; Pulmonx, Inc., Redwood City, CA, USA) targeting atelectasis of the treated, emphysematous lobe [1, 2]. However, post-procedural clinical improvement has also been documented in patients lacking lobar exclusion 3. While volumetric and density adaptations following ELVR have repeatedly been a focus [3, 4], the interaction of volume and perfusional/ventilatory changes remains unclear. In this observational study, we defined the extent of interdependency of ELVR-mediated volumetric and scintigraphic adaptations. EBV treatment reduces target lobe volume, ventilation and perfusion with consistent redistributive pattern http://ow.ly/C95Ue
Thermal waters as cosmeceuticals: La Roche-Posay thermal spring water example

The curative use of thermal spring water is well known, but further investigation of its biological properties and therapeutic benefits is necessary. This present article reports all available scientific data concerning La Roche-Posay Thermal Spring Water and provides a better understanding of the biological mechanism of action of this water in regard to its composition and physicochemical properties and its clinical benefits for patients. These data justify the use of this selenium-rich water as an active or “cosmeceutical” ingredient in topical formulations to increase quality of life and compliance in patients with chronic disease.
.‫املقالة‬ ‫لهذه‬ ‫الكامل‬ ‫النص‬ ‫نهاية‬ ‫يف‬ ‫الخالصة‬ ‫لهذه‬ ‫العربية‬ ‫الرتجمة‬ an Estimate of the Global Prevalence and Incidence of Herpes Simplex Virus Type 2 Infection

Objective To estimate the global prevalence and incidence of herpes simplex virus type 2 (HSV-2) infection in 2003. Methods A systematic review was undertaken of published seroprevalence surveys describing the prevalence or incidence of HSV-2 by age and gender. For each of 12 regions, pooled prevalence values by age and gender were generated in a random-effect model. HSV-2 incidence was then estimated from these pooled values using a constant-incidence model. Values of the HSV-2 seroprevalence from the model fits were applied to the total population to estimate the numbers of people infected. Findings The total number of people aged 15–49 years who were living with HSV-2 infection worldwide in 2003 is estimated to be 536 million, while the total number of people who were newly infected with HSV-2 in 2003 is estimated to be 23.6 million. While the estimates are limited by poor availability of data, general trends are evident. For example, more women than men were infected, and the number infected increased with age. Although prevalence varied substantially by region, predicted prevalence was mostly higher in developing regions than developed regions. Conclusion The prevalence of HSV-2 is relatively easy to measure since infection is lifelong and has a specific serological test. The burden of disease is less easy to quantify. Despite the often sparse data on which these estimates are based, it is clear that HSV-2 infection is widespread. The dramatic differences in prevalence between regions are worthy of further exploration. Une traduction en français de ce résumé figure à la fin de l'article. Al final del artículo se facilita una traducción al español.
Epigenetic Modification of the Glucocorticoid Receptor Gene Is Linked to Traumatic Memory and Post-Traumatic Stress Disorder Risk in Genocide Survivors

Recent evidence suggests that altered expression and epigenetic modification of the glucocorticoid receptor gene (NR3C1) are related to the risk of post-traumatic stress disorder (PTSD). The underlying mechanisms, however, remain unknown. Because glucocorticoid receptor signaling is known to regulate emotional memory processes, particularly in men, epigenetic modifications of NR3C1 might affect the strength of traumatic memories. Here, we found that increased DNA methylation at the NGFI-A (nerve growth factor-induced protein A) binding site of the NR3C1 promoter was associated with less intrusive memory of the traumatic event and reduced PTSD risk in male, but not female survivors of the Rwandan genocide. NR3C1 methylation was not significantly related to hyperarousal or avoidance symptoms. We further investigated the relationship between NR3C1 methylation and memory functions in a neuroimaging study in healthy subjects. Increased NR3C1 methylation–which was associated with lower NR3C1 expression–was related to reduced picture recognition in male, but not female subjects. Furthermore, we found methylation-dependent differences in recognition memory-related brain activity in men. Together, these findings indicate that an epigenetic modification of the glucocorticoid receptor gene promoter is linked to interindividual and gender-specific differences in memory functions and PTSD risk.
Power Handling of the Tungsten Divertor in JET

With incident power densities of 5-10MW/m or higher, divertor target plates of large tokamaks are driven close to the material limits. The power handling performance is essential to their characterisation. The thermal performance of tungsten is critical to the decision as to whether to start ITER with an all tungsten divertor. In the new ITER-like Wall in JET, the divertor tiles consist of carbon-fibre composites coated with tungsten except for a specific row within the range of the outer strike point (horizontal target) where bulk tungsten is used. The multilayer coating (Mo/W) is 12-25m thick depending on the poloidal position. Ion beam tests have shown that the risk of delamination is low (<1% area) as long as the coating is maintained below 1200°C and carbidisation is negligible. The tiles are coated by combined magnetron sputtering and ion implantation (CMSII). The bulk tungsten row consists of 48 tile assemblies. Each one is made of two sets of four stacks of 24 lamellae. The stacks are aligned with the toroidal direction. To minimise the risk of fracture, the brittle tungsten is subjected by the clamping to compression forces only. The surface temperature was initially limited to 1200°C to avoid appreciable grain growth and possible thermo-mechanical fatigue (no higher temperature was recorded, by the infrared systems up to now: Tsurf<1200°C). Densities of deposited energy in the order of 2030 MJ/m were reached so far. The modelled temperature rise of the plasma-facing tungsten components shows a fair agreement with the records of thermocouples and of infrared cameras. The experimental behaviour is close to the design values in a wide range of operational parameters. Special protruding lamellae were designed to expose leading edges with a vertical step  0.3mm with the aim of deliberate melting. These future investigations are intended to support ITER since melting is the highest risk for a solid tungsten divertor.
Avian bic, a Gene Isolated from a Common Retroviral Site in Avian Leukosis Virus-Induced Lymphomas That Encodes a Noncoding RNA, Cooperates with c-myc in Lymphomagenesis and Erythroleukemogenesis

ABSTRACT bic is a novel gene identified at a common retroviral integration site in avian leukosis virus-induced lymphomas and has been implicated as a collaborator with c-myc in B lymphomagenesis. It lacks an extensive open reading frame and is believed to function as an untranslated RNA (W. Tam, Gene 274:157-167, 2001; W. Tam, D. Ben-Yehuda, and W. S. Hayward, Mol. Cell. Biol. 17:1490-1502, 1997). The oncogenic potential of bic, particularly its ability to cooperate with c-myc in oncogenesis, was tested directly by expressing c-myc and bic, either singly or in pairwise combination, in cultured chicken embryo fibroblasts (CEFs) and in chickens using replication-competent retrovirus vectors. Coexpression of c-myc and bic in CEFs caused growth enhancement of cells. Most importantly, chick oncogenicity assays demonstrated that bic can cooperate with c-myc in lymphomagenesis and erythroleukemogenesis. The present study provides direct evidence for the involvement of untranslated RNAs in oncogenesis and provides further support for the role of noncoding RNAs as riboregulators.
Zero Pronoun Resolution in Japanese Discourse Based on Centering Theory

Recently there have been a number of works that model the zero pronoun resolution with the concept called 'center. ' However, the usefulness of the previous centering frameworks has not fully evaluated with naturally occurring discourses. Furthermore, the previous centering theory has handled only the phenomena in successive simple sentences and has not adequately addressed the way to handle complex sentences that are prevalent in naturally occurring discourses. In this paper, we present a method to handle complex sentences with the centering theory and describe our framework that identifies the autecedents of zero pronouns in naturally occurring Japanese discourses. We also present the evaluation of our framework with real discourses.
Cytotechnologists and On-Site Evaluation of Adequacy

While fine needle aspiration (FNA) is certainly not a new biopsy technique, recent developments in advanced imaging techniques, molecular testing, and targeted therapies have coincided with a rapid increase in the number of FNA procedures being performed. Concurrently, the demand for on-site evaluation of adequacy (OSEA) has also increased, outstripping the capacity of available cytopathologists at some institutions. Among the several alternatives to cytopathologist-performed OSEA, cytotechnologist-attended OSEA stands out because it preserves the representation of the pathology service at the time of the procedure. Herein, we review the current literature about OSEA and the necessity of cytotechnologists to expand access of this useful pathology service to a broader patient population. We also examine how cytotechnologists are likely to fit into the emerging practice of telecytology.
GPS Velocity and Strain Rate Fields in Southwest Anatolia from Repeated GPS Measurements

Southwestern Turkey is a tectonically active area. To determine kinematics and strain distribution in this region, a GPS network of sixteen stations was established. We have used GPS velocity field data for southwest Anatolia from continuous measurements covering the period 2003 to 2006 to estimate current crustal deformation of this tectonically active region. GPS data were processed using GAMIT/GLOBK software and velocity and strain rate fields were estimated in the study area. The measurements showed velocities of 15–30 mm/yr toward the southwest and strain values up to 0.28–8.23×10−8. Results showed that extension has been determined in the Burdur-Isparta region. In this study, all of strain data reveal an extensional neotectonic regime through the northeast edge of the Isparta Angle despite the previously reported compressional neotectonic regime. Meanwhile, results showed some small differences relatively with the 2006 model of Reilinger et al. As a result, active tectonic movements, in agreement with earthquake fault plane solutions showed important activity.
Compensation for the mutual coupling effect in uniform circular arrays for 2D DOA estimations employing the maximum likelihood technique

An effective compensation method for the mutual coupling effect in uniform circular arrays (UCAs) employed for two-dimensional (2D) direction-of-arrival (DOA) estimations is introduced. A new 2D DOA searching algorithm using the maximum likelihood technique optimized by the emperor selective genetic algorithm (ML-EMSGA) is introduced for use with UCAs. This method circumvents the difficulty of dealing with coherent signals in 2D DOA estimations. ML-EMSGA is less computationally demanding than the maximum likelihood method (MLM) and statistically more efficient. Our study shows that ML-EMSGA can be effectively combined with the proposed compensation method, which is based on the introduction of a new mutual impedance, to give very accurate and robust 2D DOA estimation results. The structure of mutual impedance matrix for UCAs under the compensation method is fully explained. The theory of the ML-EMSGA for the UCAs is formulated. Computer simulation examples on several synthetic scenarios are presented to demonstrate the effectiveness of the mutual coupling compensation method and the superior performance of the ML-EMSGA for UCAs.
Chronostratigraphy of CRP-2/2A, Victoria Land Basin, Antarctica

The 624.15 m glaciomarine sedimentary succession recovered in the CRP-2/2A drillcore comprises lower Oligocene (< c. 31 Ma) to lower Miocene (18.5 Ma) strata that are overlain by a thin succession of Pliocene and Pleistocene strata. The age model for the CRP-2/2A drillhole, as presented in this paper, is based on combined microfossil biostratigraphy, 40Ar/39Ar ages on volcanic material, 87Sr/86Sr analyses on mollusc shells, and correlation of a magnetic polarity zonation to the magnetic polarity time scale (MPTS). Between 25.92 and 109.05 metres below sea floor (mbsf), several alternative correlations to the MPTS are possible, all of which suggest that sediment accumulation rates averaged ~180 m/m.y. between unconformities, although actual sedimentation rates may have been higher. Between 109.05 and 306.65 mbsf, the age model is straightforward and average sedimentation rates were much higher (≥1000 m/m.y.). Between 306.65 mbsf and the bottom of the drillcore (624.15 mbsf), fewer datums are available to constrain the age model and unique correlation with the MPTS is not possible, although high average sediment accumulation rates are likely. A significant unconformity is identified at 306.65 mbsf, which may represent as much as 5 m.y. of missing time. Additional unconformities at 25.92 and 130.27 mbsf account for c. 16 and 2.5 m.y. of missing time, respectively. The Oligocene lower Miocene interval documented in the CRP-2/2A drillcore spans about 13 million years, however, it is possible that more time is missing in sequence-bounding unconformities than is represented in the stratigraphic record recovered in the CRP-2/2A drillcore.
Disk with High Oxacillin Content Discriminates between Methicillin-Resistant and Borderline Methicillin-SusceptibleStaphylococcus aureus Strains in Disk Diffusion Assays Using a Low Salt Concentration

ABSTRACT A separation between mecA+ strains ofStaphylococcus aureus and strains lacking mecAwas achieved by the disk diffusion assay and the agar dilution method, utilizing disks containing 5 μg of oxacillin and inocula of approximately 5 × 105 CFU/spot, respectively, provided that agar with 0 to 0.5% NaCl and incubation at 30°C were employed. The 5-μg oxacillin disks clearly discriminated between borderline methicillin-susceptible and mecA+strains. The oxacillin MICs were more affected by the inoculum density and salt concentration than were the methicillin MICs, and oxacillin MICs of 4 to 16 μg/ml were obtained for strains lackingmecA. Significantly higher levels of β-lactamase production and reduced oxacillin susceptibilities were recorded for strains lacking mecA, in particular strains of phage group V, when agar with ≥2% NaCl was used than when agar with 0 to 0.5% NaCl was employed. The results indicate that the borderline methicillin-susceptible phenotype is a salt-dependent in vitro phenomenon of questionable clinical relevance.
Thread scheduling for cache locality

This paper describes a method to improve the cache locality of sequential programs by scheduling fine-grained threads. The algorithm relies upon hints provided at the time of thread creation to determine a thread execution order likely to reduce cache misses. This technique may be particularly valuable when compiler-directed tiling is not feasible. Experiments with several application programs, on two systems with different cache structures, show that our thread scheduling method can improve program performance by reducing second-level cache misses.
Effects of ambient temperature on the FXG radiochromic gels used for 3-D dosimetry

Environmental effects on the optical properties of a sensitive radiochromic gel dosemeter; in particular storage, irradiation and measurements temperature were studied. Knowledge of light temperature and other ambient effects help to optimise working conditions and minimize errors. A ferrous-sulphate dosemeter with xylenol orange ion indicator incorporated in a gelatin gel matrix (FXG) was prepared under normal working conditions, and the samples were then kept in closed storage area at different temperature ranging from 5? C up to the gel melting temperature about 35? C. The samples optical absorbance was then measured quantitatively using double beam spectrophotometry. There is a small and steady increase in the absorbance 0.3? 10-3 /? C with increasing temperature until about 30? C when we observe a big jump in the gel absorbance. Finally, additional important behaviour of FXG material was noticed, that is the changes occurred under the influence of rising temperature are reversible which is different from the permanent radiation caused changes.