Miracle-dz/UniFAR-FTUs huggingface dataset:
Roles of Peroxisomes in the Rice Blast Fungus

The rice blast fungus, Magnaporthe oryzae, is a model plant pathogenic fungus and is a severe threat to global rice production. Over the past two decades, it has been found that the peroxisomes play indispensable roles during M. oryzae infection. Given the importance of the peroxisomes for virulence, we review recent advances of the peroxisomes roles during M. oryzae infection processes. We firstly introduce the molecular mechanisms and life cycles of the peroxisomes. And then, metabolic functions related to the peroxisomes are also discussed. Finally, we provide an overview of the relationship between peroxisomes and pathogenicity.
Dietary patterns and their associations with demographic, lifestyle and health variables in a random sample of British adults

The present study aimed to identify dietary patterns, from the frequency of consumption of food items and some semiquantitative data, in a random sample of 9003 British adults, and to examine the associations of the main dietary patterns with demographic factors, lifestyle habits, measures of self- reported health and mortality. Principal component analysis was used to identify four main dietary patterns, and analysis of variance employed to examine the characteristics associated with them. The four components explained, respectively, 10·2, 7·3, 5·1 and 4·9% of the total dietary variation. Component 1, frequent fruit, salad and vegetable consumption with infrequent consumption of high-fat foods, was associated with middle age, non-manual socio-economic groups, non- and ex-smokers, ‘sensible’ drinkers, small households, the south of the country, and self-assessed ‘excellent’ or ‘good’ health. Component 2, frequent consumption of high-starch foods, most vegetables and meat, was popular with young men, older men and women, large households, non-smokers, non-drinkers and those who viewed themselves as healthy. Component 3, frequent consumption of high-fat foods, was predominantly consumed by young people, smoking women, ‘high-risk’ drinkers, and men reporting many illness and/or malaise symptoms. Component 4, high positive loadings for sweets, biscuits and cakes, with negative weightings for vegetables, was most favoured by students, the elderly, those living alone, residents in Scotland, but not those in central England, and those who did not smoke. For women only the first component was associated with low all-cause mortality, and the third component with excess mortality
Competition between Networks: A Study of the Market for Yellow Pages

This paper estimates the importance of network effects in the market for Yellow Pages. I estimate three simultaneous equations: consumer demand for usage of a directory, advertiser demand for advertising and a publisher's first-order condition (derived from profit-maximizing behaviour). Estimation shows that advertisers value consumer usage and that consumers value advertising, implying a network effect. I find that internalizing network effects would significantly increase surplus. As an application, I consider whether the market benefits from monopoly (which takes advantage of network effects) or oligopoly (which reduces market power). I find that a more competitive market is preferable. Copyright 2004, Wiley-Blackwell.
Trends and Cardiovascular Mortality Effects of State-Level Blood Pressure and Uncontrolled Hypertension in the United States

Background— Blood pressure is an important risk factor for cardiovascular disease and mortality and has lifestyle and healthcare determinants that vary across states. Only self-reported hypertension status is measured at the state level in the United States. Our aim was to estimate levels and trends in state-level mean systolic blood pressure (SBP), the prevalence of uncontrolled systolic hypertension, and cardiovascular mortality attributable to all levels of higher-than-optimal SBP. Methods and Results— We estimated the relationship between actual SBP/uncontrolled hypertension and self-reported hypertension, use of blood pressure medication, and a set of health system and sociodemographic variables in the nationally representative National Health and Nutrition Examination Survey. We applied this relationship to identical variables from the Behavioral Risk Factor Surveillance System to estimate state-specific mean SBP and uncontrolled hypertension. We used the comparative risk assessment methods to estimate cardiovascular mortality attributable to higher-than-optimal SBP. In 2001–2003, age-standardized uncontrolled hypertension prevalence was highest in the District of Columbia, Mississippi, Louisiana, Alabama, Texas, Georgia, and South Carolina (18% to 21% for men and 24% to 26% for women) and lowest in Vermont, Minnesota, Connecticut, New Hampshire, Iowa, and Colorado (15% to 16% for men and ≈21% for women). Women had a higher prevalence of uncontrolled hypertension than men in every state by 4 (Arizona) to 7 (Kansas) percentage points. In the 1990s, uncontrolled hypertension in women increased the most in Idaho and Oregon (by 6 percentage points) and the least in the District of Columbia and Mississippi (by 3 percentage points). For men, the worst-performing states were New Mexico and Louisiana (decrease of 0.6 and 1.3 percentage points), and the best-performing states were Vermont and Indiana (decrease of 4 and 3 percentage points). Age-standardized cardiovascular mortality attributable to higher-than-optimal SBP ranged from 200 to 220 per 100 000 (Minnesota and Massachusetts) to 360 to 370 per 100 000 (District of Columbia and Mississippi) for women and from 210 per 100 000 (Colorado and Utah) to 370 per 100 000 (Mississippi) and 410 per 100 000 (District of Columbia) for men. Conclusions— Lifestyle and pharmacological interventions for lowering blood pressure are particularly needed in the South and Appalachia, and with emphasis on control among women. Self-reported data on hypertension diagnosis from the Behavioral Risk Factor Surveillance System can be used to obtain unbiased state-level estimates of blood pressure and uncontrolled hypertension as benchmarks for priority setting and for designing and evaluating intervention programs.
Momentum and Post-Earnings-Announcement Drift Anomalies: The Role of Liquidity Risk

This paper investigates the components of liquidity risk that are important for asset-pricing anomalies. Firm-level liquidity is decomposed into variable and fixed price effects and estimated using intraday data for the period 1983-2001. Unexpected systematic (market-wide) variations of the variable component rather than the fixed component of liquidity are shown to be priced within the context of momentum and post-earnings-announcement drift (PEAD) portfolio returns. As the variable component is typically associated with private information (e.g., Kyle (1985)), the results suggest that a substantial part of momentum and PEAD returns can be viewed as compensation for the unexpected variations in the aggregate ratio of informed traders to noise traders.
BRAND EQUITY IN INTERNET BUSINESS : AN EXPLORATORY STUDY

Previous research suggests that brand equity is shaped by various marketing mix elements, such as store image or distribution intensity. However, because the Internet has no physical boundary, some of these traditional marketing variables may not be applicable in shaping the brand equity of online firms. Drawing on theories in economics, marketing and psychology, we develop a model of brand equity formation that pertains to Internet businesses. Inside our model, we explore the significance of several Web-based marketing variables that could affect consumer perceptions of product quality and brand knowledge, both of which are relevant components of brand equity. By performing structural equation and regression analyses on two sets of survey data, we find that product/technology innovation and Website quality contribute to improving an online firm’s brand equity. The effect of advertising intensity on perceived quality is mixed, but advertising always improves the brand knowledge of consumers. These results shed important strategic implications for online firms who are building up new brands on the Internet.
Fast statistical model of TiO2 thin-film memristor and design implication

The emerging memristor devices have recently received increased attention since HP Lab reported the first TiO2-based memristive structure. As it is at nano-scale geometry size, the uniformity of memristor device is difficult to control due to the process variations in the fabrication process. The incurred design concerns in a memristor-based computing system, e.g, neuromorphic computing, can be very severe because the analog states of memristors are heavily utilized. Therefore, the understanding and quantitative characterization of the impact of process variations on the electrical properties of memristors become crucial for the corresponding VLSI designs. In this work, we examined the theoretical model of TiO2 thin-film memristors and studied the relationships between the electrical parameters and the process variations of the devices. A statistical model based on a process-variation aware memristor device structure is extracted accordingly. Simulations show that our proposed model is 3 ∼ 4 magnitude faster than the existing Monte-Carlo simulation method, with only ∼ 2% accuracy degradation. A variable gain amplifier (VGA) is used as the case study to demonstrate the applications of our model in memristor-based circuit designs.
Investigation of QF-PCR Application for Rapid Prenatal Diagnosis of Chromosomal Aneuploidies in Iranian Population

Objective G-Banding followed by standard chromosome analysis is routinely used for prenatal detection of chromosomal abnormalities. In recent years, molecular cytogenetic techniques have been developed for rapid diagnosis of chromosomal abnormalities. Among these methods Quantitative Florescence Polymerase Chain Reaction (QF-PCR) has been widely used for this purpose. Heterozygosity of short tandem repeat (STR) markers which leads to informativity is the most critical requirement for feasibility of QF-PCR. Methods In this study we analyzed several short tandem repeats on chromosomes 13, 18, 21, X and Y on amniotic fluid samples obtained from PND candidates to diagnose conditions such as Down, Edward and Patau syndromes and also numerical sex chromosome abnormalities such as Klinefelter and Turner syndromes. Findings Most of the analyzed STRs had acceptable heterozygosity (66.3-94.7) to be used in QF-PCR based prenatal diagnosis. Moreover, results obtained from both methods (standard karyotype and QF-PCR) for all samples were in accordance with each other. Conclusion In case of using appropriate STR markers, and in certain clinical indications, QF-PCR could be used as useful technique for prenatal diagnosis even in consanguine populations such as Iranians.
Unwilling or Unable to Cheat? Evidence from a Randomized Tax Audit Experiment in Denmark

This paper analyzes a randomized tax enforcement experiment in Denmark. In the base year, a stratified and representative sample of over 40,000 individual income tax filers was selected for the experiment. Half of the tax filers were randomly selected to be thoroughly audited, while the rest were deliberately not audited. The following year, "threat-of-audit" letters were randomly assigned and sent to tax filers in both groups. Using comprehensive administrative tax data, we present four main findings. First, we find that the tax evasion rate is very small (0.3%) for income subject to third-party reporting, but substantial (37%) for self-reported income. Since 95% of all income is third-party reported, the overall evasion rate is very modest. Second, using bunching evidence around large and salient kink points of the nonlinear income tax schedule, we find that marginal tax rates have a positive impact on tax evasion, but that this effect is small in comparison to avoidance responses. Third, we find that prior audits substantially increase self-reported income, implying that individuals update their beliefs about detection probability based on experiencing an audit. Fourth, threat-of-audit letters also have a significant effect on self-reported income, and the size of this effect depends positively on the audit probability expressed in the letter. All these empirical results can be explained by extending the standard model of (rational) tax evasion to allow for the key distinction between self-reported and third-party reported incomes.
Offer and use of virtual and face-to-face mentoring: perceptions of nursing tutors and students / Oferta y uso de tutorías virtuales y presenciales: percepciones de profesores y estudiantes de enfermería

Abstract The aims of this study are to compare the perceptions of tutors and students of nursing at the University of Seville (Spain) on the offer, use and time distribution of face-to-face and virtual mentoring, to analyse the influence of socio-demographic variables on this, and to find out which tools tutors use for virtual mentoring. A descriptive correlational study with 181 professors and 1,015 students is carried out, in which a previously validated questionnaire is applied; the analysis is supported with SPSS 18.0. The majority of tutors affirm that face-to-face mentoring is used the most. The tool used the most in virtual mentoring is email. It is observed that the characteristics of the mentoring are influenced by the tutor’s teaching experience and dedication, their academic background and qualifications and the educational centre where it takes place. Virtual mentoring is presented as a strategy that allows students greater access to and use of mentoring. However, not only the use of e-mail should be promoted, but also the use of other communication tools at the same time, such as chats and video calls, since students require speedy attention that is also fluid and personalized.
Laminar condensation on a moving drop. Part 1. Singular perturbation technique

In this paper, laminar condensation on a spherical drop in a forced flow is investigated. The drop experiences a strong, radial, condensation-induced velocity while undergoing slow translation. In view of the high condensation velocity, the flow field, although the drop experiences slow translation, is not in the Stokes-flow regime. The drop environment is assumed to consist of a mixture of saturated steam (condensable) and air (non-condensable). The study has been carried out in two different ways. In Part 1 the continuous phase is treated as quasi-steady and the governing equations for this phase are solved through a singular perturbation technique. The transient heat-up of the drop interior is solved by the series-truncation numerical method. The solution for the total problem is obtained by matching the results for the continuous and dispersed phases. In Part 2 both the phases are treated as fully transient and the entire set of coupled equations are solved by numerical means. Validity of the quasi-steady assumption of Part 1 is discussed. Effects due to the presence of the non-condensable component and of the drop surface temperature on transport processes are discussed in both parts. A significant contribution of the present study is the inclusion of the roles played by both the viscous and the inertial effects in the problem treatment.
Comparison of the Efficacy of Combination Therapy of Prednisolone - Acyclovir with Prednisolone Alone in Bell’s Palsy

Objective Bell’s palsy is a rapid onset, usually, unilateral paralysis of the facial nerve that causes significant changes in an individual’s life such as a decline in personal, social, and educational performance. This study compared efficacy of combined prednisolone and acyclovir therapy with prednisolone alone. Materials & Methods This study is a randomized controlled trial conducted on 43 Children (2–18 years old) with Bell’s palsy. The first group of 23 patients was treated with prednisolone and the remaining patients were treated with a combination of prednisolone and acyclovir. The required data were extracted, using an informational form based on the House-Brackmann Scale, which grades facial nerve paralysis. The data were analyzed with Mann-Whitney test using SPSS version 16. Results The mean age of the first and second group were 8.65 ± 5.07 and 8.35 ± 4.92 years, respectively, (p=0.84). Sixty one percent and 39% of patients in the first group, and 45% and 55% of patients in the second group were male and female, respectively. No significant differences exist between the groups in terms of age and gender. The rate of complete recovery was 65.2% in group I and 90% in the group II (p=0.04). Conclusion The results of this study showed that the combined prednisolone and acyclovir therapy of patients with Bell’s palsy is far more effective than treatment with prednisolone alone. Actually, age and gender had no impact on the rate of recovery.
Scorpion in Combination with Gypsum: Novel Antidiabetic Activities in Streptozotocin-Induced Diabetic Mice by Up-Regulating Pancreatic PPARγ and PDX-1 Expressions

The management of diabetes without any side effects remains a challenge in medicine. In this study, antidiabetic activity and the mechanism of action of scorpion combined with gypsum (SG) were investigated. Streptozotocin-induced diabetic mice were orally administrated with scorpion (200 mg kg−1 per day) in combination with gypsum (200 mg kg−1 per day) for 5 weeks. SG treatment resulted in decreased body weight, blood glucose and lipid levels, and increased serum and pancreatic insulin levels in diabetic mice. Furthermore, SG significantly increased the number and volume of beta cells in the Islets of Langerhans and promoted peroxisome proliferator-activated receptor gamma and pancreatic duodenal homeobox 1 expressions in pancreatic tissues. However, scorpion or gypsum alone had no significant effect in this animal model. Metformin showed a slight or moderate effect in this diabetic model, but this effect was weak compared with that of SG. Taken together, SG showed a new antidiabetic effect in streptozotocin-induced diabetic mice. This effect may possibly be involved in enhancing beta-cell regeneration and promoting insulin secretion by targeting PPARγ and PDX-1. Moreover, this new effect of SG offers a promising step toward the treatment of diabetic patients with beta-cell failure as a complementary and alternative medicine.
Citizens' perceptions of corruption and e-governance in Jordan, Ethiopia and Fiji - the need for a marketing approach

The purpose of this research is to assess citizen’s perceptions of corruption and e-governance in Jordan, Ethiopia and Fiji. The research is based on surveys using structured questionnaires and focus group interviews. Conclusions are derived from a mix of descriptive and inferential analysis. The survey covers a total of 1212 respondents using stratified sampling. Findings reveal that public-sector corruption and demands for bribes are increasing in each country. Only a few people are aware of e-governance and feel that it can help in curbing corruption. The study proposes that to mitigate negative forces in the implementation of e-governance such as corruption, digital divide and urban bias, developing countries need to apply a marketing approach to e-governance services.
Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats.

Several agents may treat cocaine addiction and toxicity including bromocriptine, desipramine, GBR 12909 [1-(2-(bis(4-fluorphenyl)-methoxy)-ethyl)-4-(3-phenyl-propyl) piperazine], diazepam, buprenorphine and dizocilpine. In this study, we sought to determine whether these specific therapeutic agents alter cardiovascular responses to cocaine in conscious rats. Arterial pressure responses to cocaine (5 mg/kg, i.v.) were similar in all rats whereas cardiac output responses varied widely. In 26 of 33 rats (named vascular responders), cocaine induced a decrease in cardiac output of 8% or more. The remaining rats with little change or an increase in cardiac output were classified as mixed responders. Pretreatment with bromocriptine (0.1 mg/kg) or desipramine (1 mg/kg) increased cardiac output in mixed responders and increased systemic vascular resistance in vascular responders similar to the differential effects noted with cocaine. GBR 12909 (0.5-10 mg/kg) elicited a decrease in cardiac output at higher doses. Diazepam (0.1 and 0.5 mg/kg) had small, short-lasting effects on cardiovascular parameters. Buprenorphine (0.3 mg/kg) or the NMDA (N-methyl-D-aspartic acid) receptor antagonist, dizocilpine (0.05 mg/kg), increased arterial pressure, heart rate and cardiac output in vascular responders. Bromocriptine and desipramine prevented the difference in cardiac output responses in vascular and mixed responders by reducing the cocaine-induced decrease in cardiac output in vascular responders. Pretreatment with GBR 12909 (1 mg/kg) had little effect on cardiovascular responses to cocaine except to depress the increase in cardiac output noted in mixed responders. Buprenorphine selectively enhanced the increase in systemic vascular resistance whereas dizocilpine enhanced the pressor response. These data suggest that several treatment regimens for cocaine addiction alter the cardiovascular responses to cocaine and that dopamine D2 receptor activation may be necessary for the decrease in cardiac output noted in vascular responders.
Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics

Inhibitor of differentiation (Id) family helix-loop-helix proteins regulate the proliferation, survival and differentiation of numerous cell types during development; however, their functions during retinal development have not been analyzed. Using loss-of-function and overexpression assays in zebrafish, we demonstrate that Id2a levels modulate retinoblast cell cycle kinetics and thereby influence neuron and glia formation in the retina. Id2a-deficient retinas possess increased numbers of cells occupying S phase, at the expense of mitotic cells, and kinetic analyses demonstrate that Id2a is required for S-phase progression and/or the transition from S to M phase. Id2a-dependent defects in retinoblast proliferation lead to microphthalmia and to an absence of nearly all differentiated inner and outer nuclear layer cell types. Overexpression of id2a has the opposite effect on retinoblast cell cycle kinetics: id2a-overexpressing retinoblasts progress from S to M phase more rapidly and they undergo mitosis more frequently, which results in macrophthalmia. Mosaic analyses reveal that Id2a function in facilitating both cell cycle progression and neuronal differentiation in the retina is non-cell-autonomous, suggesting that Id2a functions upstream of the extrinsic pathways that regulate retinogenesis.