Miracle-dz/UniFAR-FTUs huggingface dataset:
SDSS IV MaNGA – spatially resolved diagnostic diagrams: a proof that many galaxies are LIERs

We study the spatially resolved excitation properties of the ionised gas in a sample of 646 galaxies using integral field spectroscopy data from SDSS-IV MaNGA. Making use of Baldwin-Philips-Terlevich diagnostic diagrams we demonstrate the ubiquitous presence of extended (kpc scale) low ionisation emission-line regions (LIERs) in both star forming and quiescent galaxies. In star forming galaxies LIER emission can be associated with diffuse ionised gas, most evident as extra-planar emission in edge-on systems. In addition, we identify two main classes of galaxies displaying LIER emission: `central LIER' (cLIER) galaxies, where central LIER emission is spatially extended, but accompanied by star formation at larger galactocentric distances, and `extended LIER' (eLIER) galaxies, where LIER emission is extended throughout the whole galaxy. In eLIER and cLIER galaxies, LIER emission is associated with radially flat, low H$\alpha$ equivalent width of line emission ($
Here Today, Gone Tomorrow? Changes in 4-Month-Olds' Physiologic and Behavioral Responses Do Not Indicate Memory for a Social Stressor

Although much is known about early memory development, only a few studies have explored infants' memory of social stress. While these few studies suggest that infants can remember stressful interactions, limitations seen in both methodology and statistical analyses give pause. In the current study, 4-month-olds and their mothers participated in both stressful and non-stressful interactions over 2 days. On Day 1, memory group infants participated in the double Face-to-Face Still-Face (FFSF) paradigm and control group infants participated in typical play. Both groups experienced the double FFSF paradigm on Day 2. Memory group infants exhibited the standard SF response but no differences in infant cortisol on Day 1. Both infant groups exhibited the standard SF response on Day 2. However, infants in the memory group, who saw the FFSF paradigm for the second time, did not demonstrate changes in cortisol or behavior indicative of memory across the 2 days. There was also no relationship between changes in cortisol and behavior for both days. The findings question the use of salivary cortisol as a measure of social stress and suggest that, although 4-month-olds reacted to the Still-Face social stressor immediately, they did not remember the following day.
Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt’s lymphoma

This study of the Leukemia and Lymphoma Molecular Profiling Project (LLMPP) shows that pediatric and adult Burkitt’s lymphoma are molecularly homogeneous, whereas ‘discrepant Burkitt’s lymphoma’ differs in underlying genetic and clinical features from typical/atypical Burkitt’s lymphoma. Background Burkitt’s lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt’s lymphoma, but also demonstrated that a subset of aggressive B-cell lymphomas not fulfilling the current World Health Organization criteria for the diagnosis of Burkitt’s lymphoma nonetheless show a molecular signature of Burkitt’s lymphoma (‘discrepant Burkitt’s lymphoma’). Given the different treatment of Burkitt’s lymphoma and diffuse large B-cell lymphomas we investigated molecular differences within gene expression-defined Burkitt’s lymphoma. Design and Methods We studied tumors from 51 Burkitt’s lymphoma patients, comprising 26 with classic Burkitt’s lymphoma, 17 with atypical Burkitt’s lymphoma and 8 with ‘discrepant Burkitt’s lymphoma’, by comparative genomic hybridization and gene expression profiling. Results Classic and atypical Burkitt’s lymphoma (excluding ‘discrepant Burkitt’s lymphoma’), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. ‘Discrepant Burkitt’s lymphoma’, however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt’s lymphoma and from diffuse large B-cell lymphoma. Moreover, this category includes lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course. Conclusions Pediatric and adult Burkitt’s lymphoma are molecularly homogeneous, whereas ‘discrepant Burkitt’s lymphoma’ differ in underlying genetic and clinical features from typical/atypical Burkitt’s lymphoma. ‘Discrepant Burkitt’s lymphoma’ may therefore form a distinct genetic subgroup of aggressive B-cell lymphomas, which show poor response to multi-agent chemotherapy.
Can implicit measures detect source information in crime-related amnesia?

ABSTRACT Participants who are asked to simulate amnesia for a mock crime have a weaker memory for this event when they have to give up their role as a feigner, than those who are not asked to feign memory loss. According to the source monitoring framework (SMF), this memory-undermining effect of simulating amnesia for a crime would be due to misattribution of the right source of information. However, we know that the content of self-generated information (e.g., feigned version of the crime) might be preserved and recognised over time as a result of elaborative cognitive processing. In the present study, we aimed to contrast these two explanations. We showed participants a mock crime video and we instructed them to either feign amnesia (simulators) or confess the mock crime (confessors). Next, a free recall memory test was administered. After one week, participants were asked to perform a personalised source monitoring task using the autobiographical Implicit Association Test (aIAT). As predicted, we found that simulators were able to discriminate the content of their self-generated feigned story of the crime from the original version. Moreover, simulators were quicker than confessors at the aIAT task. Practical and theoretical implications of our results are discussed.
Daily Biopsy Diagnosis in Surgical Pathology: Concordance Between Light Microscopy and Whole-Slide Imaging in Real-Life Conditions

Objectives The current challenge for the various digital whole-slide imaging (WSI) systems is to be definitively validated for diagnostic purposes. We designed a concordance study between glass slide and digital slide diagnosis in real-life conditions, coupled with an ergonomic study. Methods Three senior pathologists evaluated, first in glass slides and then in digital slides, 119 biopsy cases, including 749 slides, with 332 H&E saffron stains and 417 additional techniques, mainly immunohistochemistry. Results All digital slides, including specially stained slides, were interpretable. Concordance between glass slides and digital slides was observed in 87.4% of cases. Minor discordances were observed in 12 (10.1%) cases and major discordances, with therapeutic impact, in three (2.5%), including one related to WSI. The satisfaction of participants was high and increased with time. Conclusions Our study confirms the feasibility and accuracy of WSI diagnosis, even for cases having multiple samples and requiring special staining techniques, such as immunohistochemistry and in situ hybridization.
Precipitation and Dispersion Control of MnS by Deoxidation Products of ZrO2, Al2O3, MgO and MnO–SiO2 Particles in Fe–10mass%Ni Alloy

An Fe–10 mass%Ni–1mass%Mn alloy was deoxidized with Zr, Al, Mg and Si and the effect of these deoxidation particles on MnS crystallization and/or precipitation has been studied as a function of S content with forcussing on the particle dispersion in microsegregation domain. MnS cannot be uniformly dispersed in microsegregtion domain since the crystallization and/or precipitation of MnS occur only on ZrO2 or Al2O3 particles located at the region of final solidification. MnS-containing MnO–SiO2 particles can be uniformly dispersed in microsegregation domain, if the S level is low enough for particles not to be pushed. MgS and/or (Mg, Mn)S crystallize on MgO particles in Mg deoxidation. In the case of high S level, the MgO, MgS/MgO and (Mg, Mn)S/MgO particles are pushed to the region of final solidification and then MnS crystallizes and/or precipitates on the pushed particles.
Industrial Productivity in a Hotter World: The Aggregate Implications of Heterogeneous Firm Investment in Air Conditioning

How will a nation’s aggregate urban productivity be affected by climate change? The joint distribution of climate conditions and economic activity across a nation’s cities will together determine industrial average exposure to climate risk. Air conditioning (AC) can greatly reduce this heat exposure. We develop a simple model of air conditioning adoption by heterogeneous firms within an industry. Our analysis suggests that high productivity firms are more likely to adopt AC since they suffer larger productivity losses when it is hot. Given that the most productive firms produce a disproportionate share of industry-level output, we present aggregation results highlighting how the industry’s output is insulated from the heat. Our empirical analysis of the impacts of heat on total factor productivity in U.S manufacturing yields findings broadly consistent with our model’s predictions.
Management of type 2 diabetes mellitus in people with severe mental illness: an online cross-sectional survey of healthcare professionals

Objectives To establish healthcare professionals’ (HCPs) views about clinical roles, and the barriers and enablers to delivery of diabetes care for people with severe mental illness (SMI). Design Cross-sectional, postal and online survey. Setting Trusts within the National Health Service, mental health and diabetes charities, and professional bodies. Participants HCPs who care for people with type 2 diabetes mellitus (T2DM) and/or SMI in the UK. Primary and secondary outcome measures The barriers, enablers and experiences of delivering T2DM care for people with SMI, informed by the Theoretical Domains Framework. Results Respondents were 273 HCPs, primarily mental health nurses (33.7%) and psychiatrists (32.2%). Only 25% of respondents had received training in managing T2DM in people with SMI. Univariate analysis found that mental health professionals felt responsible for significantly fewer recommended diabetes care standards than physical health professionals (P<0.001). For those seeing diabetes care as part of their role, the significant barriers to its delivery in the multiple regression analyses were a lack of knowledge (P=0.003); a need for training in communication and negotiation skills (P=0.04); a lack of optimism about the health of their clients (P=0.04) and their ability to manage T2DM in people with SMI (P=0.003); the threat of being disciplined (P=0.02); fear of working with people with a mental health condition (P=0.01); a lack of service user engagement (P=0.006); and a need for incentives (P=0.04). The significant enablers were an understanding of the need to tailor treatments (P=0.04) and goals (P=0.02) for people with SMI. Conclusions This survey indicates that despite current guidelines, diabetes care in mental health settings remains peripheral. Even when diabetes care is perceived as part of an HCP’s role, various individual and organisational barriers to delivering recommended T2DM care standards to people with SMI are experienced.
Assessment of comparative effects of sodium chloride stress on various growth parameters in different verities of rice (Oryza sativa L.)

Rice (Oryza sativa L.) belongs to family Poaceae. It is a cereal grain cultivated throughout the world. Rice is one of the largest crop products of Pakistan. In the present study of two varieties of Rice (Oryza sativa L.), Swat Sella and Punjab Basmati varieties were studied in vitro for the assessment of germination and different growth parameters. These varieties were subjected in hydroponic culture to 100mM, 200mM, and 300mM of NaCl and compared with control. The increase in concentration of NaCl adversely affected the seedling germination and growth parameters. The results showed that Swat Sella rice variety showed greater average number of seeds germination, radicle length and plumule length in 100mM, 200mM, and 300mM of NaCl compared to Punjab variety. However, in controlled medium, it was observed that Punjab variety showed higher fresh weight of seedlings, plumule length, root length of plants, shoot length of plants and dry weight of plants in comparison to Swat variety. It can be concluded that the Swat Sella rice variety is better adopted and can grow better in salinity compared to Punjab variety that grows best in non-saline conditions. Keywords: Rice (Oryza sativa L.); Swat sella; Punjab basmati; NaCl; Hydroponic culture http://dx.doi. org/10.19045/bspab.2017. 60075
Income inequality and health: what have we learned so far?

Many developed countries have experienced a sharp rise in income inequality during the past three decades, and the United States is no exception (1). For example, the average annual salary in America in inflation-adjusted 1998 dollars increased from $32,522 in 1970 to $35,864 in 1999, that is, a modest 10 percent increase over three decades. By contrast over the same period, the average annual compensation of the top 100 chief executive officers rose from $1.3 million (or 39 times the pay of an average worker) to $37.5 million (or more than 1,000 times the pay of an average worker) (2). Recent trends in wealth inequality have been equally noteworthy. The net worth of families in the top decile rose by 69 percent, to $833,600 in 2001, from $493,400 in 1998. By contrast over the same period, the net worth of families in the lowest fifth of income earners rose 24 percent, to $7,900. The median accumulated wealth of families in the top 10 percent of the income distribution was 12 times that of lower-middle-income families through much of the 1990s, but in 2001, the median net worth of the top earners was about 22 times as great (3).
Effect of hybrid phenolic hollow microsphere and silica-filled vinyl ester composites

Study on phenolic hollow microspheres (PHMS)-filled vinyl ester (VE) composites has been carried out. Effect of adding PHMS fillers at different filler loading on flexural, impact, and thermal properties were studied. The impact strength increased with the addition of PHMS fillers but at the expense of flexural strength, flexural modulus, and thermal stability of the composites. The second stage of this article aims to study the effect of adding silica as second filler in PHMS-filled VE composite system, and the influence of silane treatment on the mechanical properties of silica/PHMS/VE hybrid composites. PHMS/VE composites filled with silane-treated silica were found to show an increase in flexural modulus with increasing filler content. On contrary, the untreated silica fillers were observed to provide reinforcing effect in PHMS/VE composites at rather low filler concentration. The flexural strengths of silica/PHMS/VE hybrid composites were found to decrease with addition of silica content in the composites, and further decreased with increasing in silica content for both untreated and treated silica/PHMS-filled VE composites. Addition of silane-treated silica in the composites also provided an increase in the impact resistance of the PHMS/VE composites. Interestingly, the addition of silica and PHMS fillers in VE matrix has resulting in low density composites with improved flexural modulus and impact resistance.
Axial/Bending Coupled Analysis for FRP Adhesive Lap Joints

In this paper a finite element analysis of the behavior of adhesive joints between FRP (fiber-reinforced polymers) adherents is presented. In particular, double-lap joints, in the case of both normal and shear/flexure stresses, are considered. The problem is nonlinear due to the mathematical formulation of the cohesive laws introduced to model the interfacial interactions. On the contrary, the adherents are supposed to be linear elastic up to failure. The common approach of analyzing shear/flexure behavior separately from extensional behavior, as well as disregarding the mutual effects between the normal and tangential stresses acting at the joint interfaces, has been updated. The paper takes into account the coupling effects between shear/flexure and extensional equilibrium problems. As highlighted in literature, only a coupled analysis can be considered correct when the mechanical characteristics of the adherents are quite different, as usually occurs in practice. Furthermore it also has been assumed that the adherents are shear deformable. The numerical results obtained by such an approach are presented, discussed and compared with others available in literature.
Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

Virally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment, characterized by chronic liver inflammation and regeneration processes. They ultimately lead to oncogenic mutations in many cellular signaling cascades that drive cell growth and proliferation. Oxidative stress, induced by hepatitis viruses, therefore is one of the factors that drives the neoplastic transformation process in the liver. This review summarizes current knowledge on oxidative stress and oxidative stress responses induced by human hepatitis B and C viruses. It focuses on the molecular mechanisms by which these viruses activate cellular enzymes/systems that generate or scavenge reactive oxygen species (ROS) and control cellular redox homeostasis. The impact of an altered cellular redox homeostasis on the initiation and establishment of chronic viral infection, as well as on the course and outcome of liver fibrosis and hepatocarcinogenesis will be discussed The review neither discusses reactive nitrogen species, although their metabolism is interferes with that of ROS, nor antioxidants as potential therapeutic remedies against viral infections, both subjects meriting an independent review.
Behavior of UHPFRC at High Temperatures

This paper presents the results of an experimental study carried out at high temperatures on two industrial Ultra High Performance Fibre Reinforced Concrete (UHPFRC) containing polypropylene fibres: Ductal-AF and BSI-"fire". Hot and residual compression tests with and without preload were carried out from 90°C to 700°C. We present the evolution of the stress/strain curves, the compressive strength and the modulus of elasticity with temperature. Moreover, we observed an unusual thermal dilatation of concrete, i.e. non monotonic. Several fire resistance tests on large scale elements (slabs, columns and beams) and smaller samples are presented. Applied fire scenarios were ISO 834 and Modified Hydrocarbon curves. In most cases no spalling was observed. Comparison with results obtained on reference UHPFRC without polypropylene fibres shows the effectiveness of these fibres for these material and these geometries in reducing the spalling risk.
Distinct roles of Gαi and Gβ13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions

The asymmetric division of Drosophila neuroblasts involves the basal localization of cell fate determinants and the generation of an asymmetric, apicobasally oriented mitotic spindle that leads to the formation of two daughter cells of unequal size. These features are thought to be controlled by an apically localized protein complex comprising of two signaling pathways: Bazooka/Drosophila atypical PKC/Inscuteable/DmPar6 and Partner of inscuteable (Pins)/Gαi; in addition, Gβ13F is also required. However, the role of Gαi and the hierarchical relationship between the G protein subunits and apical components are not well defined. Here we describe the isolation of Gαi mutants and show that Gαi and Gβ13F play distinct roles. Gαi is required for Pins to localize to the cortex, and the effects of loss of Gαi or pins are highly similar, supporting the idea that Pins/Gαi act together to mediate various aspects of neuroblast asymmetric division. In contrast, Gβ13F appears to regulate the asymmetric localization/stability of all apical components, and Gβ13F loss of function exhibits phenotypes resembling those seen when both apical pathways have been compromised, suggesting that it acts upstream of the apical pathways. Importantly, our results have also revealed a novel aspect of apical complex function, that is, the two apical pathways act redundantly to suppress the formation of basal astral microtubules in neuroblasts.
Recruiting Conventional Tree Architecture Models into State-of-the-Art LiDAR Mapping for Investigating Tree Growth Habits in Structure

Mensuration of tree growth habits is of considerable importance for understanding forest ecosystem processes and forest biophysical responses to climate changes. However, the complexity of tree crown morphology that is typically formed after many years of growth tends to render it a non-trivial task, even for the state-of-the-art 3D forest mapping technology—light detection and ranging (LiDAR). Fortunately, botanists have deduced the large structural diversity of tree forms into only a limited number of tree architecture models, which can present a-priori knowledge about tree structure, growth, and other attributes for different species. This study attempted to recruit Hallé architecture models (HAMs) into LiDAR mapping to investigate tree growth habits in structure. First, following the HAM-characterized tree structure organization rules, we run the kernel procedure of tree species classification based on the LiDAR-collected point clouds using a support vector machine classifier in the leave-one-out-for-cross-validation mode. Then, the HAM corresponding to each of the classified tree species was identified based on expert knowledge, assisted by the comparison of the LiDAR-derived feature parameters. Next, the tree growth habits in structure for each of the tree species were derived from the determined HAM. In the case of four tree species growing in the boreal environment, the tests indicated that the classification accuracy reached 85.0%, and their growth habits could be derived by qualitative and quantitative means. Overall, the strategy of recruiting conventional HAMs into LiDAR mapping for investigating tree growth habits in structure was validated, thereby paving a new way for efficiently reflecting tree growth habits and projecting forest structure dynamics.
Alternative administration routes and delivery technologies for polio vaccines

ABSTRACT Global polio eradication is closer than ever. Replacement of the live attenuated oral poliovirus vaccine (OPV) by inactivated poliovirus vaccine (IPV) is recommended to achieve complete eradication. Limited global production capacity and relatively high IPV costs compared to OPV spur the need for improved polio vaccines. The target product profile of these vaccines includes not only dose sparing but also high stability, which is important for stockpiling, and easy application important for (emergency) vaccination campaigns. In this review, the current status of alternative polio vaccine delivery strategies is given. Furthermore, we discuss the feasibility of these strategies by highlighting challenges, hurdles to overcome, and formulation issues relevant for optimal vaccine delivery.