Miracle-dz/UniFAR-FTUs huggingface dataset:
Validating a theory of planned behavior questionnaire to measure entrepreneurial intentions

The Theory of Planned Behavior (TPB, Ajzen, 1991) has been widely employed to predict entrepreneurial intentions. The TPB offers a coherent and generally applicable theoretical framework, which enables us to understand and predict entrepreneurial intentions by taking into account not only personal but also social factors (Krueger et al., 2000). This study presents the validation of an Entrepreneurial Intention Questionnaire (EIQ) in a sample of more than three thousand Spanish university graduates. The EIQ comprises four subscales: attitudes towards entrepreneurship, subjective norms, self-efficacy, and entrepreneurial intention. Unlike other questionnaires used in the field (Autio, Keeley, Klofsten, Parker & Hay, 2001; Krueger, Reilly & Carsrud, 2000; Liñán & Chen, 2009), EIQ follows Ajzen’s (Ajzen, 2002) methodological recommendations on how to construct a TPB questionnaire using composite measures of attitudes and subjective norms. Structural equation modeling (SEM) confirmed that the EIQ has a high reliability and predictive validity for Spanish university graduates’ entrepreneurial intentions.
Mxi1-0 regulates the growth of human umbilical vein endothelial cells through extracellular signal-regulated kinase 1/2 (ERK1/2) and interleukin-8 (IL-8)-dependent pathways

Mxi1 plays an important role in the regulation of cell proliferation. Mxi1-0, a Mxi1 isoform, has a different N-terminal amino acid sequence, intracellular location and expression profile from Mxi1. However, the precise role of Mxi1-0 in cell proliferation and the molecular mechanism underlying its function remain poorly understood. Here, we showed that Mxi1-0 suppression decreased the proliferation of human umbilical vein endothelial cells (HUVECs) along with cell accumulation in the G2/M phase. Mxi1-0 suppression also significantly decreased the expression and secretion of interleukin (IL-8). Neutralizing IL-8 in conditioned medium (CM) from Mxi1-0-overexpressed HUVECs significantly eliminated CM-induced proliferation of HUVECs. In addition, Mxi1-0 suppression significantly decreased the activity of MAP kinase ERK1/2. Treatment of HUVECs with U0126, an ERK1/2 signaling inhibitor, attenuated autocrine production of IL-8 induced by Mxi1-0 overexpression. On the other hand, Mxi1-0 overexpression-induced IL-8 increased the level of phosphorylated ERK1/2 in HUVECs, and such increasing was diminished in cells incubated with CM, which neutralized with anti-IL-8 antibody. Taken together, our results suggest that Mxi1-0 regulates the growth of HUVECs via the IL-8 and ERK1/2 pathways, which apparently reciprocally activate each other.
Canonical Correlation Analysis of Student Perception on Instructional Quality and Satisfaction

The study models student perceptions on instructional quality and student satisfaction using canonical correlation analysis. Data from two survey occasions were modeled to assess the strength and relative consistency of the instructional quality variables in predicting student satisfaction. Results show that student's perception on the adequacy, usefulness, accessibility, safety and convenience of the learning facilities and their perception on the faculty teaching strategies and subject matter knowledge are the most influential factors of student satisfaction. Canonical functions and cross-loadings derived from the data sets show similar pattern or trend which is taken to indicate consistency of the models. The implication of the findings to managing student satisfaction among higher education institutions is briefly discussed.
Mechanical design and dynamic analysis of planetary rover

For improvement of planetary rover locomotion, a new type of tracked vehicle was designed for planetary exploration based on the concept of reconfigurability. By applying the planetary wheel principle, the system can give output in different forms under various constraint conditions. As a reconfigurable module, the vehicle can be integrated into a larger system using two basic configurations. As a stand-alone rover, it has two moving modes. The whole design was analyzed by conducting dynamics simulations and experiments
Flaviviral NS4b, chameleon and jack‐in‐the‐box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention

Dengue virus and other flaviviruses such as the yellow fever, West Nile, and Japanese encephalitis viruses are emerging vector‐borne human pathogens that affect annually more than 100 million individuals and that may cause debilitating and potentially fatal hemorrhagic and encephalitic diseases. Currently, there are no specific antiviral drugs for the treatment of flavivirus‐associated disease. A better understanding of the flavivirus–host interactions during the different events of the flaviviral life cycle may be essential when developing novel antiviral strategies. The flaviviral non‐structural protein 4b (NS4b) appears to play an important role in flaviviral replication by facilitating the formation of the viral replication complexes and in counteracting innate immune responses such as the following: (i) type I IFN signaling; (ii) RNA interference; (iii) formation of stress granules; and (iv) the unfolded protein response. Intriguingly, NS4b has recently been shown to constitute an excellent target for the selective inhibition of flavivirus replication. We here review the current knowledge on NS4b. © 2015 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd.
The End of the Line for a Brain-Damaged Model of Unilateral Neglect

For more than a century, it has been known that damage to the right hemisphere of the brain can cause patients to be unaware of the contralesional side of space. This condition, known as unilateral neglect, represents a collection of clinically related spatial disorders characterized by the failure in free vision to respond, explore, or orient to stimuli predominantly located on the side of space opposite the damaged hemisphere. Recent studies using the simple task of line bisection, a conventional diagnostic test, have proven surprisingly revealing with respect to the spatial and attentional impairments involved in neglect. In line bisection, the patient is asked to mark the midpoint of a thin horizontal lie on a sheet of paper. Neglect patients generally transect far to the right of the center. Extensive studies of line bisection have been conducted, manipulating-among other factors-line length, orientation, and position. We have simulated the pattern of results using an existing computational model of visual perception and selective attention called MORSEL (Mozer, 1991). MORSEL has already been used to model data in a related disorder, neglect dyslexia (Mozer & Behrmann, 1990). In this earlier work, MORSEL was lesioned in accordance with the damage we suppose to have occurred in the brains of neglect patients. The same model and lesion can simulate the detailed pattern of performance on line bisection, including the following observations: (1) no consistent across-subject bias is found in normals; (2) transection displacements are proportional to line length in neglect patients; (3) variability of displacements is proportional to line length, in both normals and patients; (4) position of the lines with respect to the body or the page on which they are drawn has little effect; and (5) for lines drawn at different orientations, displacements are proportional to the cosine of the orientation angle. MORSEL fails to account for one observation: across patients, the variability of displacements for a particular line length is roughly proportional to mean displacement. Nonetheless, the overall fit of the model is sufficiently good that we believe MORSEL can be used as a diagnostic tool to characterize the specific nature of a patient's deficit, and thereby has potential down the line in therapy.
Impact of Shifting Patterns of Pacific Ocean Warming on North Atlantic Tropical Cyclones

El Niño's Cousin The most energetic and well-known quasi-periodic, air-sea temperature disturbance is ENSO, the mother of the warming of equatorial eastern Pacific surface waters known as El Niño. El Niño, and its cold sister La Niña, can produce dramatic effects on weather across the globe and so it is of great interest and importance to understand it better. Warming in the eastern tropical Pacific is not the only recurring pattern of sea-surface temperature variability in the Pacific, however. Kim et al. (p. 77; see the Perspective by Holland) report that a pattern of extensive warming in the central Pacific also occurs on a quasi-periodic basis, that it has a large effect on atmospheric circulation, and that it is more predictable than El Niño. These central Pacific warming events have become increasingly more frequent in the last few decades, making it even more vital that we understand them. Warming of the central Pacific sea surface causes different patterns of atmospheric circulation than do El Niño events. Two distinctly different forms of tropical Pacific Ocean warming are shown to have substantially different impacts on the frequency and tracks of North Atlantic tropical cyclones. The eastern Pacific warming (EPW) is identical to that of the conventional El Niño, whereas the central Pacific warming (CPW) has maximum temperature anomalies located near the dateline. In contrast to EPW events, CPW episodes are associated with a greater-than-average frequency and increasing landfall potential along the Gulf of Mexico coast and Central America. Differences are shown to be associated with the modulation of vertical wind shear in the main development region forced by differential teleconnection patterns emanating from the Pacific. The CPW is more predictable than the EPW, potentially increasing the predictability of cyclones on seasonal time scales.
Exploring innovation

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Interorganization Contagion in Corporate Philanthropy

Funding for this research was provided to Professor Galaskiewicz by the Program for Nonprofit Organizations at Yale University and the National Science Foundation (SES-8008570) and to Professor Burt by Columbia University's Faculty Development Program, the National Science Foundation (SES-8208203), and consulting revenues to the Research Program in Structural Analysis. The discussion has been improved in response to comments from Roberto Fernandez, Mark Mizruchi, Gerald Salancik, Thomas Schqtt, and the ASO referees. Two network contagion models are used to describe corporate contributions officers' evaluations of nonprofit organizations seeking philanthropic donations. Contagion by cohesion predicts that behavioral communication between contributions officers results in their sharing the same evaluation. Contagion by structural equivalence predicts that symbolic communication via role playing between officers similarly positioned in the interorganization network of contributions officers results in similar evaluations. We find strong evidence of contagion, robust over differences in the evaluated nonprofit organizations and differences between officers. The evidence is overwhelmingly of contagion by structural equivalence. '
The checkered operational history of high-temperature gas-cooled reactors

ABSTRACT The high-temperature gas-cooled reactor (HTGR) has long been considered a promising nuclear technology, and several countries are either considering the construction of new HTGRs or pursuing research into the field. In the past, both Germany and the United States spent large amounts of money to design and construct HTGRs, four of which fed electricity into the grid. Examining the performances of these HTGRs offers a useful guide to what one can expect from future HTGRs, if and when more are constructed, and reasons to reject that option altogether.
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

TRAF2 is a component of TNF superfamily signalling complexes and plays an essential role in the regulation and homeostasis of immune cells. TRAF2 deficient mice die around birth, therefore its role in adult tissues is not well-explored. Furthermore, the role of the TRAF2 RING is controversial. It has been claimed that the atypical TRAF2 RING cannot function as a ubiquitin E3 ligase but counterclaimed that TRAF2 RING requires a co-factor, sphingosine-1-phosphate, that is generated by the enzyme sphingosine kinase 1, to function as an E3 ligase. Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-κB and MAP kinase signalling and caused epidermal hyperplasia and psoriatic skin inflammation. This inflammation was driven by TNF, cell death, non-canonical NF-κB and the adaptive immune system, and might therefore represent a clinically relevant model of psoriasis. TRAF2 therefore has essential tissue specific functions that do not overlap with those of Sphk1. DOI: http://dx.doi. org/10.7554/eLife.10592. 001
Second cancers in patients with chronic lymphocytic leukemia.

BACKGROUND Reports to date have provided widely divergent estimates of the risk of second malignant neoplasms in patients with chronic lymphocytic leukemia (CLL), ranging from cancer deficits to excesses of twofold to threefold. PURPOSE Our purpose was to estimate the risk of second primary cancers following CLL, utilizing population-based tumor registries, and to determine whether site-specific excesses might be associated with type of initial treatment for CLL. METHODS We analyzed data for 9456 patients diagnosed with CLL as a first primary cancer between 1973 and 1988, who were reported to one of nine tumor registries participating in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program and who survived 2 or more months. SEER files were searched for invasive primary malignancies that developed at least 2 months after the initial CLL diagnosis. RESULTS Compared with the general population, CLL patients demonstrated a significantly increased risk of developing all second cancers (840 observed; observed-to-expected ratio [O/E] = 1.28; 95% confidence interval [CI] = 1.19-1.37). Significant excesses were noted for cancers of the lung (O/E = 1.90), brain (O/E = 1.98), and eye (intraocular melanoma) (O/E = 3.97) as well as malignant melanoma (O/E = 2.79) and Hodgkin's disease (O/E = 7.69). Cancer risk, which did not vary according to initial treatment category, was also constant across all time intervals after CLL diagnosis. CONCLUSION CLL patients are at a significantly increased risk of developing a second malignant neoplasm. The pattern of cancer excesses suggests a susceptibility state permitting the development of selected second malignancies in patients with CLL, perhaps because of shared etiologic factors, immunologic impairment, and/or other influences. Although our results do not suggest a strong treatment effect, more detailed studies of second tumors in CLL are needed to investigate the role of radiation therapy and chemotherapy.
DUTH at TREC 2015 Clinical Decision Support Track

In this report we give an overview of our participation in the TREC 2015 Clinical Decision Support Track. We present two approaches for pre-processing and indexing of the open-access PubMed articles, and four methods for query construction which are applied to the previous two approaches. Regarding pre-processing, our main assumption is that only particular medical study designs are appropriate for each type of clinical question and we filter the number of articles in each clinical question type. Regarding query construction, our main idea is to detect the medical concepts in the medical cases and to expand them with terms of semantic controlled vocabularies (such as UMLS). The track evaluation shows that our approaches provide comparable results with the other participants’ approaches without to conclude on safe findings.
Reduction of CD18 Promotes Expansion of Inflammatory γδ T Cells Collaborating with CD4+ T Cells in Chronic Murine Psoriasiform Dermatitis

IL-17 is a critical factor in the pathogenesis of psoriasis and other inflammatory diseases. The impact of γδ T cells, accounting for an important source of IL-17 in acute murine IL-23– and imiquimod-induced skin inflammation, in human psoriasis is still unclear. Using the polygenic CD18hypo PL/J psoriasis mouse model spontaneously developing chronic psoriasiform dermatitis due to reduced CD18/β2 integrin expression to 2–16% of wild-type levels, we investigated in this study the influence of adhesion molecule expression on generation of inflammatory γδ T cells and analyzed the occurrence of IL-17–producing γδ and CD4+ T cells at different disease stages. Severity of CD18hypo PL/J psoriasiform dermatitis correlated with a loss of skin-resident Vγ5+ T cells and concurrent skin infiltration with IL-17+, IL-22+, and TNF-α+ γδTCRlow cells preceded by increases in Vγ4+ T cells in local lymph nodes. In vitro, reduced CD18 levels promoted expansion of inflammatory memory-type γδ T cells in response to IL-7. Similar to IL-17 or IL-23/p19 depletion, injection of diseased CD18hypo PL/J mice with anti-γδTCR Abs significantly reduced skin inflammation and largely eliminated pathological γδ and CD4+ T cells. Moreover, CD18hypo γδ T cells induced allogeneic CD4+ T cell responses more potently than CD18wt counterparts and, upon adoptive transfer, triggered psoriasiform dermatitis in susceptible hosts. These results demonstrate a novel function of reduced CD18 levels in generation of pathological γδ T cells that was confirmed by detection of increases in CD18low γδ T cells in psoriasis patients and may also have implications for other inflammatory diseases.
Aging of running shoes and its effect on mechanical and biomechanical variables: implications for runners

Abstract This study investigates the effect of running shoes’ aging on mechanical and biomechanical parameters as a function of midsole materials (viscous, intermediate, elastic) and ground inclination. To this aim, heel area of the shoe (under calcaneal tuberosity) was first mechanically aged at realistic frequency and impact magnitudes based on a 660 km training plan. Stiffness (ST) and viscosity were then measured on both aged and matching new shoes, and repercussions on biomechanical variables (joint kinematics, muscular pre-activation, vertical ground reaction force and tibial acceleration) were assessed during a leg-extended stepping-down task designed to mimic the characteristics of running impacts. Shoes’ aging led to increased ST (means: from 127 to 154 N ∙ mm−1) and decreased energy dissipation (viscosity) (means: from 2.19 to 1.88 J). The effects induced by mechanical changes on body kinematics were very small. However, they led with the elastic shoe to increased vastus lateralis pre-activation, tibial acceleration peak (means: from 4.5 g to 5.2 g) and rate. Among the three shoes tested, the shoe with intermediate midsole foam provided the best compromise between viscosity and elasticity. The optimum balance remains to be found for the design of shoes regarding at once cushioning, durability and injury prevention.
Effects of Working Memory Load on Oscillatory Power in Human Intracranial EEG

Studies of working memory load effects on human EEG power have indicated divergent effects in different frequency bands. Although gamma power typically increases with load, the load dependency of the lower frequency theta and alpha bands is uncertain. We obtained intracranial electroencephalography measurements from 1453 electrode sites in 14 epilepsy patients performing a Sternberg task, in order to characterize the anatomical distribution of load-related changes across the frequency spectrum. Gamma power increases occurred throughout the brain, but were most common in the occipital lobe. In the theta and alpha bands, both increases and decreases were observed, but with different anatomical distributions. Increases in theta and alpha power were most prevalent in frontal midline cortex. Decreases were most commonly observed in occipital cortex, colocalized with increases in the gamma range, but were also detected in lateral frontal and parietal regions. Spatial overlap with group functional magnetic resonance imaging results was minimal except in the precentral gyrus. These findings suggest that power in any given frequency band is not a unitary phenomenon; rather, reactivity in the same frequency band varies in different brain regions, and may relate to the engagement or inhibition of a given area in a cognitive task.
Tumor testing to identify lynch syndrome in two Australian colorectal cancer cohorts

Tumor testing of colorectal cancers (CRC) for mismatch repair (MMR) deficiency is an effective approach to identify carriers of germline MMR gene mutation (Lynch syndrome). The aim of this study was to identify MMR gene mutation carriers in two cohorts of population‐based CRC utilizing a combination of tumor and germline testing approaches.