Miracle-dz/UniFAR-FTUs huggingface dataset:
A Layered Architecture for Uniform Version Management

Version management is a key part of software configuration management. A big variety of version models has been realized in both commercial systems and research prototypes. These version models differ with respect to the objects put under version control (files, directories, entities, objects), the organization of versions (version graphs versus multidimensional version spaces), the granularity of versioning (whole software products versus individual components), emphasis on states versus emphasis on changes (state-versus change-based versioning), rules for version selection, etc. We present a uniform version model-and its support architecture-for software configuration management. Unlike other unification approaches, such as UML for object-oriented modeling, we do not assemble all the concepts having been introduced in previous systems. Instead, we define a base model that is built on a small number of concepts. Specific version models may be expressed in terms of this base model. Our approach to uniform version management is distinguished by its underlying layered architecture. Unlike the main stream of software configuration management systems, our instrumentable version engine is completely orthogonal to the data model used for representing software objects and their relationships. In addition, we introduce version rules at the bottom of the layered architecture and employ them as a uniform mechanism for expressing different version models. This contrasts to the main stream solution, where a specific version model-usually version graphs-is deeply built into the system and version rules are dependent on this model.
Gastric Xanthoma: A Review of the Literature

Context: Xanthelasmas, also known as “xanthomas” and “lipid islands” are yellow plaque-like lesions characterized by the presence of lipid-containing histiocytes. Evidence Acquisition: Xanthomas are most commonly found in the stomach within the gastrointestinal tract, and at this location they are called Gastric Xanthoma (GX). Clinical significance of GX is still unknown. It has been suggested that GX could be related to gastric injury. Here we reviewed five decades of studies on GX in the literature. Results: Since, GXs was reported to be associated with potentially serious conditions of the stomach, the whole gastric mucosa should be examined carefully and biopsy should be taken from the lesion during the upper gastrointestinal endoscopy for diagnosis and rulling out gastric malignity. Conclusions: Gastric xanthomas should not be ignored and concomitant conditions should be treated.
Is Tomorrow Another Day? The Labor Supply of New York City Cabdrivers

The labor supply of taxi drivers is consistent with the existence of intertemporal substitution. My analysis of the stopping behavior of New York City cabdrivers shows that daily income effects are small and that the decision to stop work at a particular point on a given day is primarily related to cumulative daily hours to that point. This is in contrast to the analysis of Camerer et al., who find that the daily wage elasticity of labor supply of New York City cabdrivers is substantially negative, implying large daily income effects. This difference in findings is due to important differences in empirical methods and to problems with the conception and measurement of the daily wage rate used by Camerer et al.
Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2

Bacterial sepsis results in high mortality rates, and new therapeutics to control infection are urgently needed. Here, we investigate the therapeutic potential of fibrates in the treatment of bacterial sepsis and examine their effects on innate immunity. Fibrates significantly improved the survival from sepsis in mice infected with Salmonella typhimurium, which was paralleled by markedly increased neutrophil influx to the site of infection resulting in rapid clearance of invading bacteria. As a consequence of fibrate‐mediated early control of infection, the systemic inflammatory response was repressed in fibrate‐treated mice. Mechanistically, we found that fibrates preserve chemotaxis of murine neutrophils by blocking LPS‐induced phosphorylation of ERK. This results in a decrease of G protein‐coupled receptor kinase‐2 expression, thereby inhibiting the LPS‐mediated downregulation of CXCR2, a chemokine receptor critical for neutrophil recruitment. Accordingly, application of a synthetic CXCR2 inhibitor completely abrogated the protective effects of fibrates in septicemia in vivo. Our results unravel a novel function of fibrates in innate immunity and host response to infection and suggest fibrates as a promising adjunct therapy in bacterial sepsis.
Transcriptome Analysis Reveals Signature of Adaptation to Landscape Fragmentation

We characterize allelic and gene expression variation between populations of the Glanville fritillary butterfly (Melitaea cinxia) from two fragmented and two continuous landscapes in northern Europe. The populations exhibit significant differences in their life history traits, e.g. butterflies from fragmented landscapes have higher flight metabolic rate and dispersal rate in the field, and higher larval growth rate, than butterflies from continuous landscapes. In fragmented landscapes, local populations are small and have a high risk of local extinction, and hence the long-term persistence at the landscape level is based on frequent re-colonization of vacant habitat patches, which is predicted to select for increased dispersal rate. Using RNA-seq data and a common garden experiment, we found that a large number of genes (1,841) were differentially expressed between the landscape types. Hexamerin genes, the expression of which has previously been shown to have high heritability and which correlate strongly with larval development time in the Glanville fritillary, had higher expression in fragmented than continuous landscapes. Genes that were more highly expressed in butterflies from newly-established than old local populations within a fragmented landscape were also more highly expressed, at the landscape level, in fragmented than continuous landscapes. This result suggests that recurrent extinctions and re-colonizations in fragmented landscapes select a for specific expression profile. Genes that were significantly up-regulated following an experimental flight treatment had higher basal expression in fragmented landscapes, indicating that these butterflies are genetically primed for frequent flight. Active flight causes oxidative stress, but butterflies from fragmented landscapes were more tolerant of hypoxia. We conclude that differences in gene expression between the landscape types reflect genomic adaptations to landscape fragmentation.
Perfectly Secure Key Distribution for Dynamic Conferences

A key distribution scheme for dynamic conferences is a method by which initially an (off-line) trusted server distributes private individual pieces of information to a set of users. Later any group of users of a given size (a dynamic conference) is able to compute a common secure key. In this paper we study the theory and applications of such perfectly secure systems. In this setting, any group of t users can compute a common key by each user computing using only his private piece of information and the identities of the other t - 1 group users. Keys are secure against coalitions of up to k users, that is, even if k users pool together their pieces they cannot compute anything about a key of any t-size conference comprised of other users.First we consider a non-interactive model where users compute the common key without any interaction. We prove a lower hound on the size of the user's piece of information of (k+t-1 t-1) times the size of the common key. We then establish the optimality of this bound, by describing and analyzing a scheme which exactly meets this limitation (the construction extends the one in [2]). Then, we consider the model where interaction is allowed in the common key computation phase, and show a gap between the models by exhibiting an interactive scheme in which the user's information is only k + t - 1 times the size of the common key. We further show various applications and useful modifications of our basic scheme. Finally, we present its adaptation to network topologies with neighborhood constraints.
Representing Multilingual Data as Linked Data: the Case of BabelNet 2.0

Recent years have witnessed a surge in the amount of semantic information published on the Web. Indeed, the Web of Data, a subset of the Semantic Web, has been increasing steadily in both volume and variety, transforming the Web into a ‘global database’ in which resources are linked across sites. Linguistic fields -- in a broad sense -- have not been left behind, and we observe a similar trend with the growth of linguistic data collections on the so-called ‘Linguistic Linked Open Data (LLOD) cloud’. While both Semantic Web and Natural Language Processing communities can obviously take advantage of this growing and distributed linguistic knowledge base, they are today faced with a new challenge, i.e., that of facilitating multilingual access to the Web of data. In this paper we present the publication of BabelNet 2.0, a wide-coverage multilingual encyclopedic dictionary and ontology, as Linked Data. The conversion made use of lemon, a lexicon model for ontologies particularly well-suited for this enterprise. The result is an interlinked multilingual (lexical) resource which can not only be accessed on the LOD, but also be used to enrich existing datasets with linguistic information, or to support the process of mapping datasets across languages.
Model and control of tendon-sheath transmission systems

In this paper, the tendon-sheath driving system for a robotic hand is presented and its force transmission characteristics are analyzed. The use of tendon-based transmission permits to reduce the size and the complexity of the actuation chain in many mechanical devices. A simple static model that describes the tendon-sheath driving system is presented, and its behavior is compared both with simulative results, obtained with a lumped parameters model of the tendon, and with experimental results. Different static and dynamic friction models are used in the simulations and the related results are compared to highlight some phenomena that are not visible from the static model of the tendon. A simple force control algorithm with feedforward friction compensation based on the static friction model is also presented
Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

DDX3X encodes a DEAD-box family RNA helicase (DDX3) commonly mutated in medulloblastoma, a highly aggressive cerebellar tumor affecting both children and adults. Despite being implicated in several facets of RNA metabolism, the nature and scope of DDX3′s interactions with RNA remain unclear. Here, we show DDX3 collaborates extensively with the translation initiation machinery through direct binding to 5′UTRs of nearly all coding RNAs, specific sites on the 18S rRNA, and multiple components of the translation initiation complex. Impairment of translation initiation is also evident in primary medulloblastomas harboring mutations in DDX3X, further highlighting DDX3′s role in this process. Arsenite-induced stress shifts DDX3 binding from the 5′UTR into the coding region of mRNAs concomitant with a general reduction of translation, and both the shift of DDX3 on mRNA and decreased translation are blunted by expression of a catalytically-impaired, medulloblastoma-associated DDX3R534H variant. Furthermore, despite the global repression of translation induced by arsenite, translation is preserved on select genes involved in chromatin organization in DDX3R534H-expressing cells. Thus, DDX3 interacts extensively with RNA and ribosomal machinery to help remodel the translation landscape in response to stress, while cancer-related DDX3 variants adapt this response to selectively preserve translation.
Teacher Trust in District Administration

Purpose: We set out in this study to establish a foundation for a line of inquiry around teacher trust in district administration by (1) describing the role of trust in capacity building, (2) conceptualizing trust in district administration, (3) developing a scale to measure teacher trust in district administration, and (4) testing the relationship between district trust and teacher commitment. Method: Teachers were the unit of analysis. Data were collected from a sample of teachers in one urban school district. Construct validity was assessed by examining content, structural, and convergent validity of the scale. A fully latent structural equation model was used to test the relationship between teacher trust in district administration and teacher commitment. Results: This study makes a strong case for developing a line of research on teacher trust in district administration. It establishes a good measure to use in future research, and it provides initial evidence showing that teacher beliefs are sensitive to the actions of district administrators. Implications: A valid and reliable measure can be used by researchers to study systematically the formation and effects of teacher trust in district administration. Accurate information on district trust also allows central office leaders to formatively assess the capacity of the school system to accomplish reform objectives at scale.
The Misuse of Prescription Opioids: A Threat for Europe?

In the the past two decades the medical use of prescription opioids (POs), in particular oxycodone, increased up to 14-fold in the U.S. and Canada. The high consumption of these pain relievers also led to non-medical use and abuse of these substances which in turn resulted in a dramatic increase in the number of PO related fatalities and opioid dependent subjects. In the U.S. POs became the second most prevalent type of abused drug (4.5 million abusers; 1.7% of the population) after marijuana (8 million abusers) with currently 1.9 million (0.7% of the population) people dependent on opioid pain relievers. Pain relief was the leading motive for non-medical use in about 40% of the cases, but about half of non-medical PO users reported non-pain relief motives only, like to get high or to relax. Since 2011, there is a decline in the use and misuse of POs and reduction in painkiller overdose deaths in the U.S. probably due to the introduction of a variety of restrictive regulations. In Europe, the medical use of POs is increasing as well, but at a much slower rate than in the U.S. Moreover, in Europe non-medical use of POs and fatal PO incidents are (still) rare. The paper highlights and discusses the differences between Europe versus U.S. and Canada in an attempt to assess the risk of a PO abuse and overdose epidemic in Europe. It is concluded that the risk in Europe seems to be rather limited but vigilance is needed
The symplectic geometry of a parametrized scalar field on a curved background

We study the real, massive Klein–Gordon field on a C∞ globally‐hyperbolic background space–time with compact Cauchy hypersurfaces. In particular, the parametrization of this system as initiated by Dirac and Kuchař is put on a rigorous basis. The discussion is focussed on the structure of the set of spacelike embeddings of the Cauchy manifold into the space–time, and on the associated e‐tensor density bundles and their tangent and cotangent bundles. The dynamics of the field is expressed as a set of automorphisms of the space of initial data in which each pair of embeddings defines one such automorphism. Using these results, the extended phase space of the system is shown to be a weak‐symplectic manifold, and the Kuchař constraint is shown to define a smooth constraint submanifold which is foliated smoothly by the constraint orbits. The pull‐back of the symplectic form to the constraint surface is a presymplectic form which is singular on the tangent spaces to the constraint orbits. Thus, the geometric str.
Introducing the OpenSource Maturity Model

The paper introduces the Open Maturity Model that is an assessment model for the Free/Libre Open Source software development process evaluation. The model was based on the knowledge about the Free/Libre Open Source Software process obtained with an extensive research of Free/Libre Open Source Software developers, users and integrators. The structure of the model resembles in many aspects the Capability Maturity Model. We decided to propose a tree level scale in order to keep it as simple as possible and make it attractive for Free/Libre Open Source Software communities. The proposed model is a means to increase the quality of the Free/Libre Open Source Software products and can promote their larger adoption.
Resonant cavity enhanced photonic devices

We review the family of optoelectronic devices whose performance is enhanced by placing the active device structure inside a Fabry‐Perot resonantmicrocavity. Such resonantcavity enhanced (RCE) devices benefit from the wavelength selectivity and the large increase of the resonant optical field introduced by the cavity. The increased optical field allows RCE photodetector structures to be thinner and therefore faster, while simultaneously increasing the quantum efficiency at the resonant wavelengths. Off‐resonance wavelengths are rejected by the cavity making RCE photodetectors promising for low crosstalk wavelength division multiplexing(WDM) applications. RCE optical modulators require fewer quantum wells so are capable of reduced voltage operation. The spontaneous emission spectrum of RCE light emitting diodes(LED) is drastically altered, improving the spectral purity and directivity. RCE devices are also highly suitable for integrated detectors and emitters with applications as in optical logic and in communication networks. This review attempts an encyclopedic overview of RCE photonicdevices and systems. Considerable attention is devoted to the theoretical formulation and calculation of important RCE device parameters. Materials criteria are outlined and the suitability of common heteroepitaxial systems for RCE devices is examined. Arguments for the improved bandwidth in RCE detectors are presented intuitively, and results from advanced numerical simulations confirming the simple model are provided. An overview of experimental results on discrete RCE photodiodes, phototransistors, modulators, and LEDs is given. Work aimed at integrated RCE devices,optical logic and WDM systems is also covered. We conclude by speculating what remains to be accomplished to implement a practical RCE WDM system.
Dissection of the role of the conserved G.U pair in group I RNA self-splicing.

Phylogenetic conservation among > 100 group I introns and previous in vitro studies have implicated a G.U pair as defining the 5'-splice site for exon ligation. The U residue defines the 3' end of the 5' exon, and the complementary G residue is part of the internal guide sequence (IGS) that base pairs to the 5' exon. We now quantitate the effect of this pair on individual reaction steps using the L-21ScaI ribozyme, which is derived from the group I intron of Tetrahymena thermophila pre-rRNA. The following results indicate that interactions with this G.U pair contribute to the binding of the 5'-exon, the positioning of the 5'-splice site with respect to the catalytic site, and the chemical step. The oligonucleotide, CCCUCU, binds to the ribozyme approximately 20-fold stronger than CCCUCC despite the fact that the U-containing oligonucleotide forms an approximately 5-fold less stable duplex with an oligonucleotide analog of the IGS, GGAGGG. This and two independent experimental observations indicate that the G.U pair contributes approximately 100-fold (3 kcal/mol, 50 degrees C) to tertiary interactions that allow the P1 duplex, which is formed between the 5'-exon and the IGS, to dock into the ribozyme's core. The approximately 50-80-fold increase in miscleavage of 5'-exon analogs upon replacement of the 3'-terminal U of CCCUCU with C or upon removal of the 3'-terminal U suggests that the tertiary interactions with the G.U pair not only contribute to docking but also ensure correct positioning of the 5'-splice site with respect to the catalytic site, thereby minimizing the selection of incorrect splice sites. Comparison of the rates of the chemical cleavage step with G.U vs G.C suggests that the G.U pair contributes approximately 10-fold to the chemical step. It was previously suggested that the 2'-hydroxyl of this U residue helps stabilize the 3'-oxyanion leaving group in the chemical transition state via an intramolecular hydrogen bond. Relative reactivities of oligonucleotide substrates with ribose and deoxyribose U and C are consistent with a model based on a recent X-ray crystallographic structure in which the exocyclic amino group of G helps orient the 2'-hydroxyl of U via a bridging water molecule, thereby strengthening the hydrogen bond donated from the 2'-hydroxyl group to the neighboring incipient 3'-oxyanion. Finally, kinetic and thermodynamic evidence for the formation of a G.C+ wobble pair is presented. (ABSTRACT TRUNCATED AT 400 WORDS)
Fine Particulate Matter and Mortality: A Comparison of the Six Cities and American Cancer Society Cohorts With a Medicare Cohort

Background: The American Cancer Society study and the Harvard Six Cities study are 2 landmark cohort studies for estimating the chronic effects of fine particulate air pollution (PM2.5) on mortality. Using Medicare data, we assessed the association of PM2.5 with mortality for the same locations included in these studies. Methods: We estimated the chronic effects of PM2.5 on mortality for the period 2000–2002 using mortality data for cohorts of Medicare participants and average PM2.5 levels from monitors in the same counties included in the 2 studies. We estimated mortality risk associated with air pollution adjusting for individual-level (age and sex) and area-level covariates (education, income level, poverty, and employment). We controlled for potential confounding by cigarette smoking by including standardized mortality ratios for lung cancer and chronic obstructive pulmonary disease. Results: Using the Medicare data, we estimated that a 10 &mgr;g/m3 increase in the yearly average PM2.5 concentration is associated with 10.9% (95% confidence interval = 9.0–12.8) and with 20.8% (14.8–27.1) increases in all-cause mortality for the American Cancer Society and Harvard Six Cities study counties, respectively. The estimates are somewhat higher than those reported by the original investigators. Conclusion: Although Medicare data lack information on some potential confounding factors, we estimated risks similar to those in the previously published reports, which incorporated more extensive information on individual-level confounders. We propose that the Medicare files can be used to construct on-going cohorts for tracking the risk of air pollution over time.