Miracle-dz/UniFAR-FTUs huggingface dataset:
Value Creation through Securitization: Evidence from the CMBS Market

Despite recent volatility and constraints in secondary market funding, analysts have ascribed substantial value creation to the securitization of commercial mortgages. Such value creation likely emanates from liquidity enhancements, regulatory arbitrage, price discrimination and risk diversification by pooling and tranching, gains from specialization in origination, servicing, and holding of mortgages, and the like. Indeed, such value creation would be consistent with past accelerated growth in the mortgage- and asset-based securities markets and the sizable profits earned by secondary market intermediaries. In this paper, we estimate the pricing effects of commercial mortgage securitization. We do so by applying loan level data from 1992–2003 to compare the pricing of conduit and portfolio loans held in CMBS structures. In contrast to portfolio loans, which are held for investment by originating institutions, conduit loans are originated for the sole purpose of sale and securitization in the secondary market. If securitization creates value, it should be evidenced in the relative pricing of conduit loans sold into CMBS pools and in a lower cost of capital to loan originators. We estimate a reduced-form model, in which the interest rate spread between commercial mortgages and comparable-maturity treasury securities varies with loan characteristics, capital market conditions, and conduit loan status. Estimation results indicate that securitization of conduit loans leads to an 11 basis points reduction in commercial mortgage interest rates. We assess robustness of results via hazard model tests for omitted variables and originator-specific effects. We further estimate a simultaneous equations model that accounts for the potential endogeneity of mortgage loan terms to the mortgage-treasury rate spread. Results of that analysis suggest a larger 20 basis points reduction in loan pricing among conduit loans sold into CMBS structures.
MurJ and a novel lipid II flippase are required for cell wall biogenesis in Bacillus subtilis

Significance The bacterial envelope is composed of a diverse set of polysaccharides. Virtually all of these polymers are synthesized from lipid-linked precursors that are flipped across the cytoplasmic membrane by ATP-binding cassette transporters or multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily members. Transport of the cell wall precursor lipid II requires the MOP family member MurJ in Escherichia coli. Here, we provide evidence for a novel lipid II flippase in Bacillus subtilis called alternate to MurJ (Amj), which bears no similarity to either family of transporters. amj is up-regulated in the absence of B. subtilis MurJ (MurJBs) via an envelope stress-response pathway, suggesting this novel flippase may serve as a defense mechanism against naturally occurring MurJ antagonists. Bacterial surface polysaccharides are synthesized from lipid-linked precursors at the inner surface of the cytoplasmic membrane before being translocated across the bilayer for envelope assembly. Transport of the cell wall precursor lipid II in Escherichia coli requires the broadly conserved and essential multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily member MurJ. Here, we show that Bacillus subtilis cells lacking all 10 MOP superfamily members are viable with only minor morphological defects, arguing for the existence of an alternate lipid II flippase. To identify this factor, we screened for synthetic lethal partners of MOP family members using transposon sequencing. We discovered that an uncharacterized gene amj (alternate to MurJ; ydaH) and B. subtilis MurJ (murJBs; formerly ytgP) are a synthetic lethal pair. Cells defective for both Amj and MurJBs exhibit cell shape defects and lyse. Furthermore, expression of Amj or MurJBs in E. coli supports lipid II flipping and viability in the absence of E. coli MurJ. Amj is present in a subset of gram-negative and gram-positive bacteria and is the founding member of a novel family of flippases. Finally, we show that Amj is expressed under the control of the cell envelope stress-response transcription factor σM and cells lacking MurJBs increase amj transcription. These findings raise the possibility that antagonists of the canonical MurJ flippase trigger expression of an alternate translocase that can resist inhibition.
Genomic HEXploring allows landscaping of novel potential splicing regulatory elements

Effective splice site selection is critically controlled by flanking splicing regulatory elements (SREs) that can enhance or repress splice site use. Although several computational algorithms currently identify a multitude of potential SRE motifs, their predictive power with respect to mutation effects is limited. Following a RESCUE-type approach, we defined a hexamer-based ‘HEXplorer score’ as average Z-score of all six hexamers overlapping with a given nucleotide in an arbitrary genomic sequence. Plotted along genomic regions, HEXplorer score profiles varied slowly in the vicinity of splice sites. They reflected the respective splice enhancing and silencing properties of splice site neighborhoods beyond the identification of single dedicated SRE motifs. In particular, HEXplorer score differences between mutant and reference sequences faithfully represented exonic mutation effects on splice site usage. Using the HIV-1 pre-mRNA as a model system highly dependent on SREs, we found an excellent correlation in 29 mutations between splicing activity and HEXplorer score. We successfully predicted and confirmed five novel SREs and optimized mutations inactivating a known silencer. The HEXplorer score allowed landscaping of splicing regulatory regions, provided a quantitative measure of mutation effects on splice enhancing and silencing properties and permitted calculation of the mutationally most effective nucleotide.
Clinical Implications of Vancomycin Heteroresistant and Intermediately Susceptible Staphylococcus aureus

Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin‐resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin‐intermediate S. aureus (hVISA) and vancomycin‐intermediate S. aureus (VISA) infections. Although vancomycin is traditionally a first‐line and relatively effective antibiotic, its continued use is under question because reports of heteroresistance in S. aureus isolates are increasing. Both hVISA and VISA infections are associated with complicated clinical courses and treatment failures. The prevalence, mechanism of resistance, clinical significance, and laboratory detection of hVISA and VISA infections are not conclusive, making it difficult to apply research findings to clinical situations. We provide an evidence‐based review of S. aureus isolates expressing heterogenic and reduced susceptibility to vancomycin.
Dorsal and ventral visual streams: Typical and atypical development

ABSTRACT The literature on visuospatial processing describes two distinct pathways within the brain: a dorsal route extending from the visual cortex into the parietal lobes that is critical for spatial processing and a ventral route extending from the visual cortex into the temporal lobes that is critical for form perception. These visual streams appear to differ in their developmental trajectories and their vulnerabilities to diverse neurodevelopmental conditions. The present work aims to investigate development and vulnerability in two aspects of dorsal and ventral visual-stream function, namely attention to location and attention to identity. In Study 1, we compare typically-developing (TD) youth aged 9 to 16 years with young adults aged 18 to 22 years on computerized location and identity tasks. In Study 2, we compare children and adolescents who have congenital hypothyroidism (CH), a pediatric endocrine disorder, with age-matched TD controls on the same tasks. The results from Study 1 show that the youths were less accurate than the adults at judging identity, whereas both groups were equally accurate at judging location. The results from Study 2 show that the youths with CH were slower but not less accurate than the TD youths in making both identity and location judgments. The results are interpreted as signifying later development of ventral (identity) stream functions compared to dorsal (location) but equal vulnerability of both functions in CH.
Bebras - a Sustainable Community Building Model for the Concept Based Learning of Informatics and Computational Thinking

As an international informatics contest, or challenge, Bebras has started the second decade of its existence. The contest attracts more and more countries every year, recently there have been over 40 participating countries. From a single contest-focused annual event Bebras developed to a multifunctional challenge and an activities-based educational community building model. This paper aims to introduce the Bebras model using ten years of observations in implementing the contest in different countries. The model is essentially based on democratic and inclusive education values. Systematic literature review of research papers concerning Bebras activities has made an integral background for this model. The model is represented both at international and national levels and consists of several components where the development of Bebras tasks has taken a very significant role. Reasoning on innovated learning informatics and strengthening computational thinking by utilising carefully selected informatics concepts is discussed as well.
A Fully Automated Web-Based Program Improves Lifestyle Habits and HbA1c in Patients With Type 2 Diabetes and Abdominal Obesity: Randomized Trial of Patient E-Coaching Nutritional Support (The ANODE Study)

Background The prevalence of abdominal obesity and type 2 diabetes mellitus (T2DM) is a public health challenge. New solutions need to be developed to help patients implement lifestyle changes. Objective The objective of the study was to evaluate a fully automated Web-based intervention designed to help users improve their dietary habits and increase their physical activity. Methods The Accompagnement Nutritionnel de l’Obésité et du Diabète par E-coaching (ANODE) study was a 16-week, 1:1 parallel-arm, open-label randomized clinical trial. Patients with T2DM and abdominal obesity (n=120, aged 18-75 years) were recruited. Patients in the intervention arm (n=60) had access to a fully automated program (ANODE) to improve their lifestyle. Patients were asked to log on at least once per week. Human contact was limited to hotline support in cases of technical issues. The dietetic tool provided personalized menus and a shopping list for the day or the week. Stepwise physical activity was prescribed. The control arm (n=60) received general nutritional advice. The primary outcome was the change of the dietary score (International Diet Quality Index; DQI-I) between baseline and the end of the study. Secondary endpoints included changes in body weight, waist circumference, hemoglobin A1c (HbA1c) and measured maximum oxygen consumption (VO2 max). Results The mean age of the participants was 57 years (standard deviation [SD] 9), mean body mass index was 33 kg/m² (SD 4), mean HbA1c was 7.2% (SD 1.1), and 66.7% (80/120) of participants were women. Using an intention-to-treat analysis, the DQI-I score (54.0, SD 5.7 in the ANODE arm; 52.8, SD 6.2 in the control arm; P=.28) increased significantly in the ANODE arm compared to the control arm (+4.55, SD 5.91 vs -1.68, SD 5.18; between arms P<.001). Body weight, waist circumference, and HbA1c changes improved significantly in the intervention. Conclusions Among patients with T2DM and abdominal obesity, the use of a fully automated Web-based program resulted in a significant improvement in dietary habits and favorable clinical and laboratory changes. The sustainability of these effects remains to be determined. Trial Registration ClinicalTrials.gov NCT02343107; http://clinicaltrials.gov/ct2/show/NCT02343107 (Archived by WebCite at http://www.webcitation.org/6uVMKPRzs)
Perceived Organizational Support

What is perceived organizational support? Perceived organizational support (POS) refers to employee perceptions regarding the extent to which their employer “values their contributions and cares about their well-being” (Eisenberger, Huntington, Hutchison, & Sowa, 1986, p. 501). In the social exchange between employees and employers, it is the organizational equivalent of employees’ commitment to the organization, though it is based on employees’ perceptions, rather than the organization’s perspective. In short, it represents “employees' inferences concerning the organization's commitment to them” (Eisenberger et al., 1986, p. 500). Beliefs about the organization’s commitment are thought to stem from employees’ interactions with other members who are seen as representatives of the organization; attributions about those members and interactions are then extended to the entire organization (Eisenberger et al., 1986). The most commonly used measure is the Survey of Perceived Organizational Support (Eisenberger et al., 1986), of which there are many versions, of varying lengths. Example items include, “The organization cares about my opinions” and “The organization strongly considers my goals and values” (Eisenberger, Cummings, Armeli, & Lynch, 1997; Eisenberger et al., 1986). In the realm of recruitment, the concept of anticipated organizational support among job candidates has also been minimally explored, by adapting the items to be future oriented (e.g., “This organization would care about my opinions”; Casper & Buffardi, 2004).
Multi-agency working: implications for an early-intervention social work team

The adoption of multi-agency working is a key component of the government’s agenda for the reconfiguration of children’s services. This study examined multi-agency working from the perspective of social workers within an early-intervention family support team. Qualitative methods were used, involving individual interviews as well as focus groups with a total of 29 professionals within the early-intervention social work team and its partner agencies. Thematic analysis of transcripts showed a number of challenges to multi-agency working, which included issues focused on differences in partner agencies’ protocols, as well as issues concerning professional status and identity. Messages for best practice that emerged stress the need for clear protocols and methods of negotiating and reviewing protocols; opportunities for informal as well as formal communication between workers; and adequate financial support and timetabling of service developments. Benefits of multi-agency working involved enhanced inter-agency respect and communication, greater understanding of child protection thresholds among partner agencies and fast-track referrals. Areas requiring further investigation include the blurring of professional boundaries for social workers delivering early-intervention services in community settings and the outcomes for children of multi-agency working in early-intervention services.
Perceptions of the News Media’s Societal Roles

A longitudinal study of U.K. journalism undergraduates records how their attitudes on societal roles of the news media changed during university education. Students became more likely to endorse an adversarial approach toward public officials and businesses as extremely important. Yet students did not support these roles as strongly as an older generation of U.K. journalists did. Students also became less likely to support the role of giving “ordinary people” a chance to express views. This may indicate a “generation gap” in attitudes that journalism educators need to understand. The authors also are concerned that the U.K. journalism workforce—now including many students from such programs—has become more socially elite.
There is More Than One Way to Do Political Science: On Different Ways to Study Policy Networks

Our recent article in this journal has provoked a series of responses to which we reply here. However, these responses are very different in tone and content and this is reflected in the balance of this reply. Dowding attacks our work in the context of a claim that, essentially, there is only one way to do social science. This critique is so fundamental that it is the focus of the first section of this reply. In contrast, Raab is mainly concerned to argue that he and McPherson cannot be classified as taking an anthropological approach to networks; indeed, he claims that their work adopts a position which has similarities with our own. Finally, Evans attempts to build upon our article, using the work of Benson, to develop what he regards as a more adequate dialectical approach. We shall deal with both of these contributions in the second section of this reply, in which we consider Dowding’s more specific criticisms of our work.
Perfect Secrecy in Physical-Layer Network Coding Systems From Structured Interference

Physical-layer network coding (PNC) has been proposed for next generation networks. In this paper, we investigate PNC schemes with embedded perfect secrecy by exploiting structured interference in relay networks with two users and a single relay. In a practical scenario where both users employ finite and uniform signal input distributions, we establish upper bounds (UBs) on the achievable perfect secrecy rates and make these explicit when pulse amplitude modulation modems are used. We then describe two simple, explicit encoders that can achieve perfect secrecy rates close to these UBs with respect to an untrustworthy relay in the single antenna and single relay setting. Last, we generalize our system to a multiple-input multiple-output relay channel, where the relay has more antennas than the users and study optimal precoding matrices, which maintain a required secrecy constraint. Our results establish that the design of PNC transmission schemes with enhanced throughput and guaranteed data confidentiality is feasible in next generation systems.
African‐American Partisanship and the Legacy of the Civil Rights Movement: Generational, Regional, and Economic Influences on Democratic Identification, 1973–1994

We explore the importance of generational effects and the changing economic circumstances of Blacks to explain variations over time in the partisan attachments of African Americans. More specifically, we explore whether generational differences have caused the cohorts that came of political age following the Civil Rights movement to be less Democratic than generations that lived through the Civil Rights movement and its aftermath. We find that while life-cycle effects explain a portion of the movement away from the two major parties, generational effects account for the small but significant increase in Republican party identification in the youngest generation. Additionally, living in the South accounts for the steepest gains in political independence. Finally, changing economic influences over time appear to have led poorer Blacks to change from the most likely to the least likely to identify with a major party.
Behavioural effects of temperature on ectothermic animals: unifying thermal physiology and behavioural plasticity

Temperature imposes significant constraints on ectothermic animals, and these organisms have evolved numerous adaptations to respond to these constraints. While the impacts of temperature on the physiology of ectotherms have been extensively studied, there are currently no frameworks available that outline the multiple and often simultaneous pathways by which temperature can affect behaviour. Drawing from the literature on insects, we propose a unified framework that should apply to all ectothermic animals, generalizing temperature's behavioural effects into (1) Kinetic effects, resulting from temperature's bottom-up constraining influence on metabolism and neurophysiology over a range of timescales (from short-to long-term), and (2) Integrated effects, where the top-down integration of thermal information intentionally initiates or modifies a behaviour (behavioural thermoregulation, thermal orientation, thermosensory behavioural adjustments). We discuss the difficulty in distinguishing adaptive behavioural changes due to temperature from behavioural changes that are the products of constraints, and propose two complementary approaches to help make this distinction and class behaviours according to our framework: (i) behavioural kinetic null modeling and (ii) behavioural ecology experiments using temperature-insensitive mutants. Our framework should help to guide future research on the complex relationship between temperature and behaviour in ectothermic animals.
Acute anxiety and social inference: An experimental manipulation with 7.5% carbon dioxide inhalation

Background: Positive self-bias is thought to be protective for mental health. We previously found that the degree of positive bias when learning self-referential social evaluation decreases with increasing social anxiety. It is unclear whether this reduction is driven by differences in state or trait anxiety, as both are elevated in social anxiety; therefore, we examined the effects on the state of anxiety induced by the 7.5% carbon dioxide (CO2) inhalation model of generalised anxiety disorder (GAD) on social evaluation learning. Methods: For our study, 48 (24 of female gender) healthy volunteers took two inhalations (medical air and 7.5% CO2, counterbalanced) whilst learning social rules (self-like, self-dislike, other-like and other-dislike) in an instrumental social evaluation learning task. We analysed the outcomes (number of positive responses and errors to criterion) using the random effects Poisson regression. Results: Participants made fewer and more positive responses when breathing 7.5% CO2 in the other-like and other-dislike rules, respectively (gas × condition × rule interaction p = 0.03). Individuals made fewer errors learning self-like than self-dislike, and this positive self-bias was unaffected by CO2. Breathing 7.5% CO2 increased errors, but only in the other-referential rules (gas × condition × rule interaction p = 0.003). Conclusions: Positive self-bias (i.e. fewer errors learning self-like than self-dislike) seemed robust to changes in state anxiety. In contrast, learning other-referential evaluation was impaired as state anxiety increased. This suggested that the previously observed variations in self-bias arise due to trait, rather than state, characteristics.
Ball bearing damage detection using traditional signal processing algorithms

Fault detection and diagnosis of ball bearings has always been a challenge when monitoring rotating machinery. Specifically, bearing diagnostics have seen extensive research in the field of fault detection and diagnosis. This article reviews traditional algorithms used to detect and diagnose faulty bearings in heavy-duty milling machine tool spindle heads. Different kinds of faults have been created deliberately on the bearings of a test spindle head. The prediction effectiveness of several detection methods are tested when faults are in different stages of development.
Modernization and consanguineous marriage in Beirut

Summary Recent data do not demonstrate any trend away from consanguineous marriages in the urban Middle East. The continued observance of this preferential custom may correspond to the persistence of an archaic trait among urban dwellers; if this holds true, then one would expect consanguineous couples to conform more to the traditional family pattern than others. In order to test this hypothesis, 100 women married to a relative and 100 matched controls, selected from a hospital setting in Beirut, were interviewed with respect to their household type (nuclear/extended), residential pattern (proximity of parents and parents-in-law's residence to theirs), contacts with family and sex definitions. A substantial proportion of the respondents comply with the traditional norms prevalent in the Middle East (25–55%, according to the criterion), but no difference is detectable between cases and controls in this respect.