Miracle-dz/UniFAR-FTUs huggingface dataset:
High Dose IVIG in the Post Partum Period for Prevention of Exacerbations in MS

The influence of pregnancy on the course of autoimmune diseases is well documented. In multiple sclerosis the European PRIMS study confirmed an ameliorating effect during pregnancy but an increase of exacerbations after delivery. The efficacy of IVIG in autoimmune mediated diseases has been frequently reported. Based on the experiences of Achiron we recommend IVIG to prevent exacerbations after delivery. Since 1995 we recommend 60 g IVIG within 3 days after delivery and 10 g monthly in patients estimated to be on high risk for exacerbation. The data were compared to the PRIMS study. The baseline data were comparable, but the exacerbation rate after delivery in our observation was 33% lower man expected. The lowest risk for an exacerbation within the first 3 months after delivery we observed in women treated with long-term IVIG monthly. Until now the overall tolerance was excellent The results with IVIG after delivery suggest that immunoglobulins may be a promising therapeutical approach not only in MS but also in other autoimmune mediated diseases with a risk of exacerbation after delivery. A European wide study with IVIG after delivery in MS is in preparation to confirm our preliminary data.
Relationship between Attitudes towards Teaching and Job Satisfaction among Secondary School Teachers in Kenya

The major purpose of the study was to investigate the relationship between attitudes towards teachings and job satisfaction among secondary school teachers. Further the study ought to investigate the strength of the relationship between Secondary school teacher’s attitudes towards teaching and the level of job satisfaction. The design of the study was expo facto. Population was secondary school teachers. Sample size was 324. The statistical package for the social sciences was used to analyze the data. Percentages and means were used to analyse the data. Pearson correlation coefficient (r) was used to measure the strength of the relationship. Among the major findings, the study revealed that majority of the teachers (65.8%) had positive attitude towards teaching. Majority (82.4%) of the teachers in the sample were not satisfied with the salary they were getting. Majority (76.9%) of the teachers in the sample were not satisfied with the promotional opportunities in the teaching profession. More than half (55.6%) of the teachers in the sample were not satisfied with the kind of supervision they were getting from the heads of the schools. More than half (55.6%) of the teachers in the sample were not satisfied with the supervision they were getting from heads of the schools. A subject which a teacher taught had an important function in determining attitudes towards teaching and job satisfaction. A teacher’s responsibility played an important role in determining attitudes towards teaching and job satisfaction. There was no strong relationship between attitudes towards teaching and job satisfaction among secondary school teachers with respect to the following variables: Age, Type of school, Teaching experience and Mother’s occupation. However, there was strong relationship with respect to: Subjects taught, Highest education attained, Position of responsibility, Father’s and Mother’s occupation, Father’s and Mother’s highest education attained. The study recommends that those appointed as heads should be given both theoretical and practical training in relation to their new roles as administrators. Based on the findings, the study concluded that attitudes towards teaching and job satisfaction are dynamically interrelated. Keywords: Job satisfaction; level job satisfaction; Attitudes towards teaching.
Analytic performance modeling for a spectrum of multithreaded processor architectures

The throughput of pipelined processors suffers from delays associated with instruction dependencies and memory latencies. Multithreaded architectures attempt to hide such delays by sharing the processor with multiple instruction streams. In this paper we develop a comprehensive analytic framework to quantitatively evaluate the performance of a wide spectrum of mulithreaded machines, ranging from those that are capable of switching threads every cycle to those that switch threads only on long delays. The models are validated against previously published simulation and modeling results, and then used to assess the performance potential of multithreading given current processor technology. <<ETX>>
Construct Validation of a Modified Religious Orientation Scale within an Islamic Context

This study added 12 new statements to the Persian version of 21-item religious orientation scale (ROS) and administered it to five hundred thirty six undergraduate students majoring in various fields in two universities in Mashhad, Iran. The application of the Principal Axis Factoring to the data and rotating the results via Varimax with Kaiser Normalization extracted seven factors, i.e., Inspirational, Intrinsic, Social, Concessional, Theopacific, Humanitarian and Sacrificial, establishing the ROS as a multidimensional ratōōher that bifactorial measure of religious orientation. The correlational analysis of the factors showed that Inspirational, Intrinsic, Social, Theo-pacific, Humanitarian and Sacrificial factors are significantly related to each other in a positive direction whereas the Concessional orientation towards religion relates significantly but negatively to the Inspirational, Intrinsic, Social, and Sacrificial factors. The implications of the findings are discussed and recommendations are made for future research.
Acute Ehrlichia platys Infection in the Dog

Ten dogs were inoculated with Ehrlichia platys (E. platys) from an acutely infected dog. Two dogs were necropsied on each of days 7, 14, 21, 28, and 35 post-inoculation, and tissues were collected and either fixed in formalin or frozen for light microscopic examination of lesions or E. platys antigen localization in tissues. Serum antibody titers to E. platys and serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activities were also determined. The significant light microscopic findings were lymph node follicular hyperplasia and crescent-shaped hemorrhages in the splenic periarteriolar lymphoid sheaths beginning day 7 post-inoculation. There was significant megakaryocyte hyperplasia of bone marrow on days 28 and 35 post-inoculation. Ehrlichia platys antigen was in macrophages at 14 days post-inoculation which corresponded to the initial decline in platelet numbers. Initial thrombocytopenia and splenic crescent-shaped hemorrhages were temporally related, however the degree of lesion development and prominence were not related to subsequent platelet numbers.
(E)-2-[(4-chlorophenyl)iminomethyl]-5-methoxyphenol and (E)-2-[(2-chlorophenyl)iminomethyl]-5-methoxyphenol: X-ray and DFT-calculated structures.

The crystal structures of the title 4-chlorophenyl, (I), and 2-chlorophenyl, (II), compounds, both C14H12ClNO2, have been determined using X-ray diffraction techniques and the molecular structures have also been optimized at the B3LYP/6-31 G(d,p) level using density functional theory (DFT). The X-ray study shows that the title compounds both have strong intramolecular O-H.N hydrogen bonds and that the crystal networks are primarily determined by weak C-H.pi and van der Waals interactions. The strong intramolecular O-H.N hydrogen bond is evidence of the preference for the phenol-imine tautomeric form in the solid state. The IR spectra of the compounds were recorded experimentally and also calculated for comparison. The results from both the experiment and theoretical calculations are compared in this study.
A Pipelined Pseudoparallel System Architecture for Real-Time Dynamic Scene Analysis

In this paper we introduce the concept of pseudoparallelism, in which the serial algorithm is partitioned into several noninteractive independent subtasks so that parallelism can be used within each subtask level. This approach is illustrated by applying it to a real-time dynamic scene analysis. Complete details of such a pseudoparallel architecture with an emphasis to avoid interprocessor communications have been worked out. Problems encountered in the course of designing such a system with a distributed operating system (no master control) have been outlined and necessary justifications have been provided. A scheme indicating various memory modules, processing elements, and their data-path requirements is included and ways to provide continuous flow of partitioned information in the form of a synchronized pipeline are described.
Concept mapping: a strategy for promoting meaningful learning in medical education

Concept mapping is an educational tool that encourages meaningful learning. Fostering meaningful and self-directed learning among medical students is now recognized as a major goal of medical educators (ACME-TRI Report, 1992). Meaningful learning (learning with understanding) is much stronger and longer-lasting than rote learning (learning by memorization) because students address the conceptual meaning of the knowledge being learned, and link this new information with previous knowledge.Concept mapping is an active, creative, visual and spatial learning activity in which concepts are organized according to their hierarchical relationships. Linking words are used to describe the relationships among the concepts. To create a concept map, students must understand the information that will appear in the map. Students must also relate and integrate the concepts that will be recorded in the map. As a result students replace unidirectional linear organization with thinking which proceeds in multiple directions.
Yeast Rtt109 Promotes Genome Stability by Acetylating Histone H3 on Lysine 56

Posttranslational modifications of the histone octamer play important roles in regulating responses to DNA damage. Here, we reveal that Saccharomyces cerevisiae Rtt109p promotes genome stability and resistance to DNA-damaging agents, and that it does this by functionally cooperating with the histone chaperone Asf1p to maintain normal chromatin structure. Furthermore, we show that, as for Asf1p, Rtt109p is required for histone H3 acetylation on lysine 56 (K56) in vivo. Moreover, we show that Rtt109p directly catalyzes this modification in vitro in a manner that is stimulated by Asf1p. These data establish Rtt109p as a member of a new class of histone acetyltransferases and show that its actions are critical for cell survival in the presence of DNA damage during S phase.
A theoretical account of lexical and semantic naming deficits in bilingual aphasia.

PURPOSE The purpose of this study was to examine premorbid language proficiency and lexical and semantic processing deficits in bilingual aphasia and develop a theoretical account of bilingual language processing. METHOD Nineteen Spanish-English patients with bilingual aphasia completed a language use questionnaire (LUQ) and were administered Spanish and English standardized language assessments. The authors analyzed the data to (a) identify patterns of lexical and semantic processing deficits and conceptualize a theoretical framework that accounts for language deficits, (b) determine LUQ measures that predict poststroke language deficits, and (c) evaluate the relationship between predictive LUQ measures and poststroke language deficits in order to identify impairment patterns. RESULTS On the basis of the results, the authors obtained significant correlations on several measures between language input and output. They identified prestroke language ability rating as the strongest predictor of poststroke outcomes. On the basis of these data, 2 distinct groups were identified: (a) patients who lost the same amount of language in Spanish and English and (b) patients who lost different amounts of Spanish and English. CONCLUSIONS These findings suggest that it is possible to identify relationships between language patterns and deficits in patients with bilingual aphasia and that these trends will be instrumental in clinical assessments of this understudied population.
On Pseudosquares and Pseudopowers

Introduced by Kraitchik and Lehmer, an $x$-pseudosquare is a positive integer $n\equiv1\pmod 8$ that is a quadratic residue for each odd prime $p\le x$, yet is not a square. We use bounds of character sums to prove that pseudosquares are equidistributed in fairly short intervals. An $x$-pseudopower to base $g$ is a positive integer which is not a power of $g$ yet is so modulo $p$ for all primes $p\le x$. It is conjectured by Bach, Lukes, Shallit, and Williams that the least such number is at most $\exp(a_g x/\log x)$ for a suitable constant $a_g$. A bound of $\exp(a_g x\log\log x/\log x)$ is proved conditionally on the Riemann Hypothesis for Dedekind zeta functions, thus improving on a recent conditional exponential bound of Konyagin and the present authors. We also give a GRH-conditional equidistribution result for pseudopowers that is analogous to our unconditional result for pseudosquares.
Urban Entrepreneurship, Corporate Interests and Sports Mega-Events: The Thin Policies of Competitiveness within the Hard Outcomes of Neoliberalism

Mega-events, otherwise referred to as hallmark or special events, are major fairs, festivals, expositions, cultural and sporting events which are held on either a regular or a one-off basis (Hall, 1992). Mega-events have assumed a key role in urban and regional tourism marketing and promotion as well as wider urban and regional development strategies. Nations, regions, cities and corporations have used mega-events to promote a favourable image in the international tourist, migration and business marketplace (Ritchie & Beliveau, 1974; Law, 1993, 2000; Malecki, 2004). Mega-events are therefore one of the means by which places seek to become ‘sticky’ (Markusen, 1996) – that is attract and retain mobile capital and people – through place enhancement and regeneration and the promotion of selective place information (Hall, C.M., 2005a, b). Mega-events are therefore an extremely significant component of place promotion because they may leave behind social, economic and physical legacies which will have an impact on the host community for a far greater period than that in which the event took place. For example, when asked as to the ‘most likely legacy’ of the 1994 Victoria Commonwealth Games in Canada a readers’ poll in Monday Magazine ranked debt, new pool, higher taxes, increased tourism, and higher real estate prices as being the Games’ legacies (McCaw, 1994). Such a lay assessment of the effects of hosting a mega-event may well be quite astute. Mega sports events such as the Olympic Games have been associated with large-scale public expenditure, the construction of facilities and infrastructure, and urban redevelopment and revitalization strategies which may have undesirable long-term consequences for public stakeholders although significant short-term gains for some corporate interests (Hall, 1992; Essex & Chalkley, 1998; Eisinger, 2000). Mega-events can be regarded as one of the hallmarks of modernity and have long managed to integrate industrial and corporate interests with those of government with respect to urban development and imaging. Arguably this is
10 Year Survey of Pretrial Examinations in Saskatchewan

Summary The results of a survey of pretrial examination cases admitted to the provincial psychiatric hospital in Saskatchewan from 1966 to 1975 are reported. The demographic and psychiatric data and data from the psychiatric reports to the Court are analyzed. Some deficiencies noted in the reports to the Court are discussed and some remedial measures are suggested.
Etiologies of Pleural Exudates after Cytology and Biopsies in Yaounde:Cameroon

Introduction: Very little is known about the frequency of the different etiologies responsible of pleural pathologies in Cameroon. The objective of this retrospective study was to identify the main etiologies of pleural pathologies based on the analysis of pleural fluid and pleural biopsy. Methods: This was a one-year retrospective study that took place in Yaounde (Yaounde, Cameroon). We reviewed the archived reports of cytological examinations of pleural fluids and histopathological reports of pleural biopsies done in 2009. Results: A total of 547 pleural specimens were collected, of which 240 were female and 307 male. Tuberculosis was the most frequent pathology in both men and women and was found mainly between 20 and 49 years of age with a peak between 30 and 39 years. One hundred and ninety-five patients performed both pleural cytology and pleural biopsy. The specific diagnosis was found in 177 (90.77%) of the cases. Overall, 152 (77.87%) specimens were diagnosed positive for tuberculosis by both tests, while 25 (12.82%) specimens were diagnosed positive for a tumor. Metastatic adenocarcinoma was by far the most frequent tumor in a total of 28 tumors, representing 89.3% of the cases Conclusion: Tuberculosis is the most frequent etiology of pleural pathology in Yaounde.
The role of two factors in a gross motor aiming task.

An experiment was carried out to determine the relation between kinaesthetic sensitivity and distance perception in a skill learning situation involving an aiming task. Kinaesthetic sensitivity was determined by establishing individual difference limens in weight discrimination, and distance perception was measured by means of a new test. The results of these two pretests were correlated with the performance of novices in learning to aim a shuttlecock with a badminton racket. The results showed that there was a significant correlation between kinaesthetic sensitivity and aiming performance and that this relation was constant throughout learning. No significant relation was found between distance perception and aiming performance, nor was there any correlation between the two pretests.
Androgen receptors in prostate cancer.

PURPOSE Androgen receptor (AR) is expressed in the majority of human prostate cancers. For a better understanding of prostate carcinoma events it is necessary to present findings on the regulation of AR target genes, AR interaction with associated proteins, ligand independent activation and point mutations. MATERIALS AND METHODS A comprehensive literature review of manuscripts published on AR in prostate cancer was performed using PubMed. RESULTS AR regulates the expression of genes involved in the proliferation and differentiation of prostate cancer cells. Due to differential interactions with coactivators and corepressors AR activation results in the stimulation of a mitogenic response or in the expression of secretory proteins. AR is functional in advanced carcinoma of the prostate, as evidenced in studies of mutant receptors and ligand independent activation. AR point mutations appear in advanced prostate cancer more frequently than in organ confined disease. CONCLUSIONS Current therapy options aimed to inhibit AR function in prostate cancer are limited. Antiandrogenic drugs frequently acquire agonistic properties in the presence of mutated ARs. In addition, androgen signaling pathway activity increases during long-term androgen ablation. AR coactivator complexes might be a target for novel therapies for prostate cancer.
Interaction between Muscle and Bone

The clinical significance of sarcopenia and osteoporosis has increased with the increase in the population of older people. Sarcopenia is defined by decreased muscle mass and impaired muscle function, which is related to osteoporosis independently and dependently. Numerous lines of clinical evidence suggest that lean body mass is positively related to bone mass, which leads to reduced fracture risk. Genetic, endocrine and mechanical factors affect both muscle and bone simultaneously. Vitamin D, the growth hormone/insulin-like growth factor I axis and testosterone are physiologically and pathologically important as endocrine factors. These findings suggest the presence of interactions between muscle and bone, which might be very important for understanding the physiology and pathophysiology of sarcopenia and osteoporosis. Muscle/bone relationships include two factors: local control of muscle to bone and systemic humoral interactions between muscle and bone. As a putative local inducer of muscle ossification, we found Tmem119, a parathyroid hormone-responsive osteoblast differentiation factor. Moreover, osteoglycin might be one of the muscle-derived humoral bone anabolic factors. This issue may be important for the development of novel drugs and biomarkers for osteoporosis and sarcopenia. Further research will be necessary to clarify the details of the linkage of muscle and bone.
Preoperative Plasma Soluble Urokinase Plasminogen Activator Receptor as a Prognostic Marker in Rectal Cancer Patients. An Eortc-Receptor and Biomarker Group Collaboration

Background and aims Since approximately 30% of patients with Dukes’ stage B colorectal cancer will experience disease recurrence within five years of primary treatment, current staging of patients with early colorectal cancer apparently fails to adequately predict patient outcome. It has previously been shown that the preoperative plasma concentration of soluble urokinase plasminogen activator receptor (suPAR) is associated with the survival of patients with early colorectal cancer. In this study we sought to confirm the independent prognostic value of suPAR in rectal cancer. Methods suPAR was retrospectively determined by two different versions of a suPAR ELISA in preoperatively collected plasma samples from a Swedish (n=354) and a Danish (n=255) cohort of rectal cancer patients. Results In both cohorts the suPAR concentration was significantly higher in Dukes’ stage D patients than in Dukes’ stage A-C patients (p<0.0001). Among Dukes’ stage A-C patients, no differences in median suPAR values were seen. In univariate analysis, continuous suPAR was found to be associated with survival (p<0.0001 in both cohorts). Of particular interest was that similar results were obtained for Dukes’ stage A and B patients when analyzed separately. In multivariate analysis, continuous suPAR was found in both cohorts to be independent of Dukes’ stage. Conclusions This study confirms that the preoperative concentration of plasma suPAR contains independent prognostic information on patients with rectal cancer. This result was independent of the two different versions of an in-house suPAR ELISA used to perform the analyses. The next step in the evaluation of suPAR as a prognostic parameter in rectal cancer will be to launch an appropriately dimensioned prospective study where the benefit of applying preoperative plasma suPAR measurement to clinical decision-making regarding adjuvant therapy is assessed.