Miracle-dz/UniFAR-FTUs huggingface dataset:
Case of femoral diaphyseal stress fracture after long-term risedronate administration diagnosed by iliac bone biopsy

Bisphosphonate excessively inhibits bone resorption and results in pathological fracture of the femur or ilium. The subject of this study was administered risedronate for 7 years; we suspected an easy fracture of the femoral diaphysis. In this study, we report the results of this patient’s bone biopsy and bone morphometric analysis. A 76-year-old female patient presented with right femoral pain. Bone mineral density of the anteroposterior surface of the 2nd to 4th lumbar vertebrae (L2–L4) was decreased and levels of bone turnover markers were high. Therefore, we initiated treatment with risedronate. As she continued the medication, urinary levels of cross-linked N-terminal telopeptides of type I collagen and alkaline phosphatase (bone-type isozyme) were found to be within the normal ranges. After 7 years of administration, the patient experienced pain when she put weight on the right femur and right femoral pain while walking. Plain radiographic examination revealed polypoid stress fracture-like lesions on the right femoral diaphysis and on the slightly distal-lateral cortical bone. Similar lesions were observed on magnetic resonance imaging and bone scintigraphy. We suspected severely suppressed bone turnover. Bone biopsy was obtained after labeling with tetracycline, and bone morphometric analysis was performed. On microscopic examination, slight double tetracycline labeling was observed. The trabeculae were narrow, and the numbers of osteoblasts and osteoclasts were decreased. Further, rates of bone calcification and bone formation were slow. Hence, we diagnosed fracture as a result of low turnover osteopathy. Risedronate was withdrawn, and Vitamin D3 was administered to improve the bone turnover. At 6 months, abnormal signals on magnetic resonance imaging had decreased and her pain while walking or undergoing the stress test disappeared as well. Thus, long-term administration of bisphosphonates may lead to easy fracture, although bone turnover markers were observed to be within the normal range. During bisphosphonate administration, physicians need to monitor closely and treat their patients for any pain experienced in the femoral region while walking or undergoing a stress test.
A multi-chromosome approach to standard and embedded cartesian genetic programming

Embedded Cartesian Genetic Programming (ECGP) is an extension of Cartesian Genetic Programming (CGP) that can automatically acquire, evolve and re-use partial solutions in the form of modules. In this paper, we introduce for the first time a new multi-chromosome approach to CGP and ECGP that allows difficult problems with multiple outputs to be broken down into many smaller, simpler problems with single outputs, whilst still encoding the entire solution in a single genotype. We also propose a multi-chromosome evolutionary strategy which selects the best chromosomes from the entire population to form the new fittest individual, which may not have been present in the population. The multi-chromosome approach to CGP and ECGP is tested on a number of multiple output digital circuits. Computational Effort figures are calculated for each problem and compared against those for CGP and ECGP. The results indicate that the use of multiple chromosomes in both CGP and ECGP provide a significant performance increase on all problems tested.
60 GHz Indoor Propagation Studies for Wireless Communications Based on a Ray-Tracing Method

This paper demonstrates a ray-tracing method for modeling indoor propagation channels at 60 GHz. A validation of the ray-tracing model with our in-house measurement is also presented. Based on the validated model, the multipath channel parameter such as root mean square (RMS) delay spread and the fading statistics at millimeter wave frequencies are easily extracted. As such, the proposed ray-tracing method can provide vital information pertaining to the fading condition in a site-specific indoor environment.
JPEG2000 compression for scintigraphic images of metastasis of the prostatic cancer

A remote DICOM (Digital Imaging Communication in Medicine) server needs an important storage and a high-speed network of, at least, 100 Mbps. This is a limitation for the storage and for remote access to images and image processing softwares. Objective: We set up, in this study, a secondary server that saves medical images of prostatic cancer patients compressed by JPEG 2000, the new standard of image compression. This first study has to set up an intranet and a remote server. Method: We compress to JPEG2000 the images picked up in PNG and Bitmap formats from the DICOM server using the scientific software MATLAB. Results: JPEG 2000 compression save the contrast of bone scintigraphic images. For the lossless compression the results are, respectively, 1.66 and 9.86 for the PNG format and Bitmap format. The lossy compression gives a compression ratio of, respectively, 6.48 and 40.3 for the two formats. The minimum and maximum for images compressed in PNG are 2.0 and 10.5 corresponding to a Peak Signal-to-Noise Ratio (PSNR) of, respectively, 62.9 dB and 37.8 dB. That lossy compression reduces all the images at the weight of 58 Kibi-octet (Kio). Conclusion: These compression ratios work with a good interpretation of the whole body bone scintigraphic images we used. That is proved by the visual metric as well as the PSNR. It also permits the image transmission through a low speed network. This makes easy the access on patient data in the hospital and eventually from a remote location.
Spectropolarimetry of the Classical T Tauri Star TW Hydrae

We present high-resolution (R ≈ 60,000) circular spectropolarimetry of the classical T Tauri star TW Hydrae. We analyze 12 photospheric absorption lines and measure the net longitudinal magnetic field for six consecutive nights. While no net polarization is detected the first five nights, a significant photospheric field of Bz = 149 ± 33 G is found on the sixth night. To rule out spurious instrumental polarization, we apply the same analysis technique to several nonmagnetic telluric lines, detecting no significant polarization. We further demonstrate the reality of this field detection by showing that the splitting between right and left polarized components in these 12 photospheric lines shows a linear trend with Landé g-factor times wavelength squared, as predicted by the Zeeman effect. However, this longitudinal field detection is still much lower than that which would result if a pure dipole magnetic geometry is responsible for the mean magnetic field strength of 2.6 kG previously reported for TW Hya. We also detect strong circular polarization in the He I λ5876 and Ca II λ8498 emission lines, indicating a strong field in the line formation region of these features. The polarization of the Ca II line is substantially weaker than that of the He I line, which we interpret as being due to a larger contribution to the Ca II line from chromospheric emission in which the polarization signals cancel. However, the presence of polarization in the Ca II line indicates that accretion shocks on classical T Tauri stars do produce narrow emission features in the infrared triplet lines of calcium.
Neural Correlates of Emotion Regulation in the Ventral Prefrontal Cortex and the Encoding of Subjective Value and Economic Utility

In many studies of the interaction between cognitive control and emotion, the orbitofrontal cortex/ventromedial prefrontal cortex (mOFC/vmPFC) has been associated with an inhibitory function on limbic areas activated by emotionally arousing stimuli, such as the amygdala. This has led to the hypothesis of an inhibitory or regulatory role of mOFC/vmPFC. In studies of cognition and executive function, however, this area is deactivated by focused effort, raising the issue of the nature of the putative regulatory process associated with mOFC/vmPFC. This issue is here revisited in light of findings in the neuroeconomics field demonstrating the importance of mOFC/vmPFC to encoding the subjective value of stimuli or their economic utility. Many studies show that mOFC/vmPFC activity may affect response by activating personal preferences, instead of resorting to effortful control mechanisms typically associated with emotion regulation. Based on these findings, I argue that a simple automatic/controlled dichotomy is insufficient to describe the data on emotion and control of response adequately. Instead, I argue that the notion of subjective value from neuroeconomics studies and the notion of attentional orienting may play key roles in integrating emotion and cognition. mOFC/vmPFC may work together with the inferior parietal lobe, the cortical region associated with attentional orienting, to convey information about motivational priorities and facilitate processing of inputs that are behaviorally relevant. I also suggest that the dominant mode of function of this ventral network may be a distinct type of process with intermediate properties between the automatic and the controlled, and which may co-operate with effortful control processes in order to steer response.
On spin 3 interacting with gravity

Recently Boulanger and Leclercq have constructed a cubic four derivative 3 − 3 − 2 vertex for the interaction of spin 3 and spin 2 particles. This vertex is trivially invariant under the gauge transformations of the spin 2 field, so it seemed that it could be expressed in terms of the (linearized) Riemann tensor. And indeed in this paper we managed to reproduce this vertex in the form R∂Φ∂Φ, where R is the linearized Riemann tensor and Φ is the completely symmetric third rank tensor. Then we consider the deformation of this vertex to (A)dS space and show that such deformation produces a ‘standard’ gravitational interaction for spin 3 particles (in the linear approximation) in agreement with general construction of Fradkin and Vasiliev. Then we turn to the massive case and show that the same higher derivative terms allow one to extend the gauge invariant description of a massive spin 3 particle from constant curvature spaces to arbitrary gravitational backgrounds satisfying Rμν = 0.
Automated Analysis of Reliability Architectures

The development of complex and critical systems calls for a rigorous and thorough evaluation of reliability aspects. Over the years, several methodologies have been introduced in order to aid the verification and analysis of such systems. Despite this fact, current technologies are still limited to specific architectures, without providing a generic evaluation of redundant system definitions. In this paper we present a novel approach able to assess the reliability of an arbitrary combinatorial redundant system. We rely on an expressive modeling language to represent a wide class of architectural solutions to be assessed. On such models, we provide a portfolio of automatic analysis techniques: we can produce a fault tree, that represents the conditions under which the system fails to produce a correct output, based on it, we can provide a function over the components reliability, which represents the failure probability of the system. At its core, the approach relies on the logical formalism of equality and uninterpreted functions, it relies on automated reasoning techniques, in particular Satisfiability Modulo Theories decision procedures, to achieve efficiency. We carried out an extensive experimental evaluation of the proposed approach on a wide class of multi-stage redundant systems. On the one hand, we are able to automatically obtain all the results that are manually obtained in [1], on the other, we provide results for a much wider class of architectures, including the cases of non-uniform probabilities and of two voters per stage.
Pannexin channels mediate the acquisition of myogenic commitment in C2C12 reserve cells promoted by P2 receptor activation

The acquisition of myoblast commitment to the myogenic linage requires rises in intracellular free Ca2+ concentration ([Ca2+]i). Putative cell membrane pathways involved in these [Ca2+]i increments are P2 receptors (P2Rs) as well as connexin (Cx) and/or pannexin (Panx) hemichannels and channels (Cx HChs and Panx Chs), respectively, which are known to permeate Ca2+. Reserve cells (RCs) are uncommitted myoblasts obtained from differentiated C2C12 cell cultures, which acquire commitment upon replating. Regarding these cells, we found that extracellular ATP increases the [Ca2+]i via P2Rs. Moreover, ATP increases the plasma membrane permeability to small molecules and a non-selective membrane current, both of which were inhibited by Cx HCh/Panx1Ch blockers. However, RCs exposed to divalent cation-free saline solution, which is known to activate Cx HChs (but not Panx Chs), did not enhance membrane permeability, thus ruling out the possible involvement of Cx HChs. Moreover, ATP-induced membrane permeability was inhibited with blockers of P2Rs that activate Panx Chs. In addition, exogenous ATP induced the expression of myogenic commitment and increased MyoD levels, which was prevented by the inhibition of P2Rs or knockdown of Panx1 Chs. Similarly, increases in MyoD levels induced by ATP released by RCs were inhibited by Panx Ch/Cx HCh blockers. Myogenic commitment acquisition thus requires a feed-forward mechanism mediated by extracellular ATP, P2Rs, and Panx Chs.
Empirical risk minimization for heavy-tailed losses

The purpose of this paper is to discuss empirical risk minimization when the losses are not necessarily bounded and may have a distribution with heavy tails. In such situations, usual empirical averages may fail to provide reliable estimates and empirical risk minimization may provide large excess risk. However, some robust mean estimators proposed in the literature may be used to replace empirical means. In this paper, we investigate empirical risk minimization based on a robust estimate proposed by Catoni. We develop performance bounds based on chaining arguments tailored to Catoni's mean estimator.
Predicting the recipients of social work support, and its impact on emotional and behavioural problems in early childhood

This paper examines the recipients of social work support in the Millennium Cohort Study. Using panel analysis and fixed effects models, it investigates the factors that lead to the receipt of any type of social work support for individuals with young children and the effects of this support on changes in the prevalence of emotional and behavioural problems in these children. We find that divorce or separation, and episodes of homelessness are two important factors that lead to the receipt of social work support. Mothers with male children are also more likely to receive social work support. However, we find no clear evidence that social work support has any effect on changes in children's emotional and behavioural problems over time. The implications of these findings for social work research and for practice and policy are discussed.
Performance of MIMO OFDM systems in fading channels with additive TX and RX impairments

The performance of OFDM based systems is seriously affected by imperfections in system implementation. To gain a beter understanding of the influence of these impairments on the performance of multiple antenna OFDM systems, this paper studies a zero-forcing based MIMO OFDM system with imperfections modeled as additive error sources in both transmitter (TX) and receiver (RX). Based on this model, expressions are derived for the probability of error of uncoded impaired MIMO systems in fading and non-fading environments. These results allow for insightful comparison between the influence of TX and RX impairments. It is concluded that the influence of RX imperfections decreases with an increasing number of RX branches, while this is not the case for TX deficiencies.
Building tractable disjunctive constraints

Many combinatorial search problems can be expressed as 'constraint satisfaction problems'. This class of problems is known to be NP-hard in general, but a number of restricted constraint classes have been identified which ensure tractability. This paper presents the first general results on combining tractable constraint classes to obtain larger, more general, tractable classes. We give examples to show that many known examples of tractable constraint classes, from a wide variety of different contexts, can be constructed from simpler tractable classes using a general method. We also construct several new tractable classes that have not previously been identified.
A Low Dimensional Description of Globally Coupled Heterogeneous Neural Networks of Excitatory and Inhibitory Neurons

Neural networks consisting of globally coupled excitatory and inhibitory nonidentical neurons may exhibit a complex dynamic behavior including synchronization, multiclustered solutions in phase space, and oscillator death. We investigate the conditions under which these behaviors occur in a multidimensional parametric space defined by the connectivity strengths and dispersion of the neuronal membrane excitability. Using mode decomposition techniques, we further derive analytically a low dimensional description of the neural population dynamics and show that the various dynamic behaviors of the entire network can be well reproduced by this reduced system. Examples of networks of FitzHugh-Nagumo and Hindmarsh-Rose neurons are discussed in detail.
Dressed for Success? The Effect of School Uniforms on Student Achievement and Behavior

Uniform use in public schools is rising, but we know little about how they affect students. Using a unique dataset from a large urban school district in the southwest United States, we assess how uniforms affect behavior, achievement and other outcomes. Each school in the district determines adoption independently, providing variation over schools and time. By including student and school fixed-effects we find evidence that uniform adoption improves attendance in secondary grades, while in elementary schools they generate large increases in teacher retention.
A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development

ADAM10 and ADAM17 are two closely related members of the ADAM (a disintegrin and metalloprotease) family of membrane-bound sheddases, which proteolytically cleave surface membrane proteins. Both ADAM10 and ADAM17 have been implicated in the proteolytic cleavage of NOTCH receptors and as such regulators of NOTCH signaling. During retinal development, NOTCH signaling facilitates retinal neurogenesis by maintaining progenitor cells in a proliferative state and by mediating retinal cell fates. However, the roles of ADAM10 and ADAM17 in the retina are not well defined. In this study, we set out to clarify the roles of ADAM10 and ADAM17 during early retinal development. The retinal phenotype of conditionally abated Adam17 retinae (Adam17 CKO) did not differ from the controls whereas conditionally ablated Adam10 retinae (Adam10 CKO) exhibited abnormal morphogenesis characterized by the formation of rosettes and a loss of retinal laminae phenotypically similar to morphological abnormalities identified in mice with retinal NOTCH signaling deficiency. Additionally, Adam10 CKO retinae exhibited abnormal neurogenesis characterized by fewer proliferating progenitor cells and greater differentiation of early photoreceptors and retinal ganglion cells. Moreover, constitutive activation of the NOTCH1-intracellular domain (N1-ICD) rescued Adam10 CKO abnormal neurogenesis, as well as abnormal retinal morphology by maintaining retinal cells in the progenitor state. Collectively these findings provide in vivo genetic evidence that ADAM10, and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH signaling.
Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M

We have generated a set of amino- and carboxy-terminal deletions of the neurofilament NF-M gene and determined the molecular consequences of forced expression of these mutant constructs in mouse fibroblasts. To follow the expression of mutant NF-M subunits in transfected cells, a 12 amino acid epitope (from the human c-myc protein) was expressed at the carboxy terminus of each mutant. We show that NF-M molecules missing up to 90 or 70% of the nonhelical carboxy-terminal tail or amino-terminal head domains, respectively, incorporate readily into an intermediate filament network comprised either of vimentin or NF-L, whereas deletions into either the amino- or carboxy-terminal alpha- helical rod region generate assembly-incompetent polypeptides. Carboxy- terminal deletions into the rod domain invariably yield dominant mutants which rapidly disrupt the array of filaments comprised of NF-L or vimentin. Accumulation of these mutant NF-M subunits disrupts vimentin filament arrays even when present at approximately 1% the level of the wild-type subunits. In contrast, the amino-terminal deletions into the rod produce pseudo-recessive mutants that perturb the wild-type NF-L or vimentin arrays only modestly. The inability of such amino-terminal mutants to disrupt wild-type subunits defines a region near the amino-terminal alpha-helical rod domain (residues 75- 126) that is required for the earliest steps in filament assembly.
THE REPRESENTATION OF JOKO WIDODO’S FIGURE IN THE JAKARTA POST

This research investigates the representation of Jokowi’s figure as the governor of Jakarta, the presidential candidate, and the President of Indonesia in the Jakarta Post by using nomination and predication strategies of Discourse Historical Approach (DHA) proposed by Reisigl and Wodak (2001). Fifteen editorials focusing on Jokowi were examined. Findings reveal three main points. First, deixis and synecdoches become the nomination strategies that signify changes. The strategies signal that the Jakarta Post prefers to focus on Jokowi when he becomes the president since his every action represents the action that the government and Indonesia take. Second, the Jakarta Post prefers to use positive predication strategies in presenting Jokowi’s figure in all categories except on the Corruption Eradication Commission (KPK) issue. Third, the signification of the representation indicates that nomination and predication strategies are employed to represent the shift in political support towards Jokowi: from positive to negative. The Jakarta Post supports Jokowi since his performance as a leader is in line with the Jakarta Post values. However, the Jakarta Post no longer gives him its full support on the KPK issue, for his action is seen to contradict the Jakarta Post ’s ideology that supports anticorruption movement.