Miracle-dz/UniFAR-FTUs huggingface dataset:
Feasibility and Clinical Value of CT-guided (125)I Brachytherapy for Bilateral Lung Recurrences from Colorectal Carcinoma.

PURPOSE To prospectively evaluate the feasibility and clinical value of computed tomography (CT)-guided iodine 125 ((125)I) brachytherapy to treat bilateral lung recurrences from colorectal carcinoma. MATERIALS AND METHODS This study was approved by Sun Yat-sen University Cancer Center Institutional Review Board and all patients provided informed written consent. Seventy-two patients with bilateral lung recurrences from colorectal carcinoma were enrolled and randomly divided into two groups. Thirty-three were percutaneously treated with CT-guided (125)I brachytherapy (group A) and the other 39 were only given symptomatic and supportive treatments (group B). Follow-up contrast agent-enhanced CT scans were reviewed and efficacy of treatment was evaluated. (125)I brachytherapy was considered a success if it achieved the computerized treatment planning system criteria 1 month after procedure. Analyses included Kaplan-Meier, Mantel-Cox log-rank test, and Cox proportional hazards regression. RESULTS In group A, 37 (125)I brachytherapy procedures were performed in 33 patients with 126 lung metastatic lesions and the success rate was 87.9% (29 of 33 patients). The local control rate of 3, 6, 12, 24, and 36 months was 75.8%, 51.5%, 33.3%, 24.2%, and 9.1%, respectively. A small amount of pulmonary hematoma occurred in five patients, and six patients presented with pneumothorax with pulmonary compression of 30%-40%. No massive bleeding or radiation pneumonitis occurred. The mean overall survival (OS) of group A was significantly longer than that of group B, and (125)I brachytherapy was an independent factor that affected the OS (group A, 18.8 months; group B, 8.6 months; hazard ratio, 0.391 [95% confidence interval: 0.196, 0.779]; P = .008). CONCLUSION CT-guided (125)I brachytherapy is feasible and safe for the treatment of bilateral lung recurrences from colorectal carcinoma.
Chemoprevention of MNU-induced mammary tumors in the mature rat by 4-HPR and tamoxifen.

The chemopreventive efficacies of the retinoid all-trans-N-(4-hydroxyphenyl)-retinamide (4-HPR) and the anti-estrogen tamoxifen citrate were evaluated against N-methyl-N'-nitrosourea (MNU) induced mammary cancer in 120-day old female Sprague-Dawley rats. The agents were tested alone and in combination. They were administered in a modified AIN-76A diet, beginning 60 days prior to a single i.v. dose of 50 mg MNU/kg-bw and continuing until the end of the study, 180 days post-carcinogen treatment. At 782 mg/kg diet, 4-HPR alone significantly inhibited the induction of mammary adenocarcinomas compared with carcinogen controls. At 0.250 mg/kg diet, tamoxifen alone reduced tumor incidence compared with carcinogen controls. At 0.125 mg/kg diet, tamoxifen was ineffective. Combinations of 782 mg 4-HPR/kg diet with either 0.250 or 0.125 mg tamoxifen/kg diet were effective in inhibiting MNU-induced adenocarcinomas. The reductions in tumor incidence were greater for these combinations than for either agent alone. 4-HPR and 0.250 mg tamoxifen/kg diet decreased tumor incidence 81% (p less than 0.005), whereas 4-HPR and 0.125 mg tamoxifen/kg diet decreased tumor incidence 72% (p less than 0.005) compared with carcinogen controls. The combination of 391 mg 4-HPR/kg diet and 0.500 mg tamoxifen/kg diet was also tested and was effective in reducing tumor incidence.
Structures of the thermophilic F1-ATPase ε subunit suggesting ATP-regulated arm motion of its C-terminal domain in F1

The ε subunit of bacterial and chloroplast FoF1-ATP synthases modulates their ATP hydrolysis activity. Here, we report the crystal structure of the ATP-bound ε subunit from a thermophilic Bacillus PS3 at 1.9-Å resolution. The C-terminal two α-helices were folded into a hairpin, sitting on the β sandwich structure, as reported for Escherichia coli. A previously undescribed ATP binding motif, I(L)DXXRA, recognizes ATP together with three arginine and one glutamate residues. The E. coli ε subunit binds ATP in a similar manner, as judged on NMR. We also determined solution structures of the C-terminal domain of the PS3 ε subunit and relaxation parameters of the whole molecule by NMR. The two helices fold into a hairpin in the presence of ATP but extend in the absence of ATP. The latter structure has more helical regions and is much more flexible than the former. These results suggest that the ε C-terminal domain can undergo an arm-like motion in response to an ATP concentration change and thereby contribute to regulation of FoF1-ATP synthase.
Predicting Eyewitness Identification Accuracy with Mock Witness Measures of Lineup Fairness: Quality of Encoding Interacts with Lineup Format

After viewing a staged crime under varying levels of encoding optimality, eyewitnesses made identifications from lineups that were either presented to them as a simultaneous line of people, or individually, in sequence. Lineups did not contain the perpetrator of the staged crime, and were purposefully constructed to have varying levels of bias. There was an interaction between encoding optimality and type of lineup, with sequential-presentation lineups leading to more correct rejections than simultaneous-presentation lineups for moderate encoding optimality. Sequential-presentation lineups did not provide good protection against mistaken identifications in the two other conditions of encoding optimality. Measures of the fairness of the lineups significantly predicted identification rates for both simultaneous-presentation lineups and sequential-presentation lineups, regardless of encoding optimality.
Literacy as Multidimensional: Locating Information and Reading Comprehension

A contrast is proposed between the two literacy constructs of reading comprehension and locating information in text. A pragmatic approach to identifying important classes of literacy tasks reveals that locating information is prevalent in school and work. This process is a form of strategic reading that differs from reading comprehension or recall of prose by being more goal directed, more selective in the use of text, and less dependent on declarative knowledge. The process of locating text information requires: formulation of a goal, selection of a category of text for inspection, extraction of relevant details, and recycling to obtain solutions. Relationships of locating information in text to models of problem solving, studying, and reading comprehension are discussed and research implications are suggested.
Contextual Variations of Infrahumanization: The Role of Physical Context and Territoriality

The malleability of the infrahumanization bias was tested varying the physical context in which the ingroup and the outgroup target were assessed. Using a sequential priming paradigm, Study 1 replicated the infrahumanization bias in a neutral context. Study 2 tested the hypothesis that there are contextual variations in infrahumanization. Specifically, Black targets were infrahumanized in a context familiar to White participants, and not in an unfamiliar context. Study 3 revealed that participants’ threat perceptions were reduced when ingroup targets appeared in familiar context, compared to Black targets. Theoretical implications for the infrahumanization bias are discussed.
Replication of Bovine Papillomavirus Type 1 (BPV-1) DNA in Saccharomyces cerevisiae following Infection with BPV-1 Virions

ABSTRACT Saccharomyces cerevisiae protoplasts exposed to bovine papillomavirus type 1 (BPV-1) virions demonstrated uptake of virions on electron microscopy. S. cerevisiae cells looked larger after exposure to BPV-1 virions, and cell wall regeneration was delayed. Southern blot hybridization of Hirt DNA from cells exposed to BPV-1 virions demonstrated BPV-1 DNA, which could be detected over 80 days of culture and at least 13 rounds of division. Two-dimensional gel analysis of Hirt DNA showed replicative intermediates, confirming that the BPV-1 genome was replicating within S. cerevisiae. Nicked circle, linear, and supercoiled BPV-1 DNA species were observed in Hirt DNA preparations from S. cerevisiae cells infected for over 50 days, and restriction digestion showed fragments hybridizing to BPV-1 in accord with the predicted restriction map for circular BPV-1 episomes. These data suggest that BPV-1 can infect S. cerevisiae and that BPV-1 episomes can replicate in the infected S. cerevisiae cells.
In vivo Reconstitution of Algal Triacylglycerol Production in Saccharomyces cerevisiae

The current fascination with algal biofuel production stems from a high lipid biosynthetic capacity and little conflict with land plant cultivation. However, the mechanisms which enable algae to accumulate massive oil remain elusive. An enzyme for triacylglycerol (TAG) biosynthesis in Chlamydomonas reinhardtii, CrDGTT2, can produce a large amount of TAG when expressed in yeast or higher plants, suggesting a unique ability of CrDGTT2 to enhance oil production in a heterologous system. Here, we performed metabolic engineering in Saccharomyces cerevisiae by taking advantage of CrDGTT2. We suppressed membrane phospholipid biosynthesis at the log phase by mutating OPI3, enhanced TAG biosynthetic pathway at the stationary phase by overexpressing PAH1 and CrDGTT2, and suppressed TAG hydrolysis on growth resumption from the stationary phase by knocking out DGK1. The resulting engineered yeast cells accumulated about 70-fold of TAG compared with wild type cells. Moreover, TAG production was sustainable. Our results demonstrated the enhanced and sustainable TAG production in the yeast synthetic platform.
Class and Work Autonomy in 21 Countries

Autonomy, or the extent to which employees can control their own work, is a central theme in debates on organizational flexibility and labour market stratification. Predictions of upskilling and autonomy, for manual workers too, have been a striking component in visions of post-Fordism and post-industrialism. The two main comparative labour market theories — the varieties of capitalism school and the power resources approach — suggest that both the level and the distribution of autonomy vary across production contexts, either because of national differences in skill requirements or because of the varying strength of organized labour. The objective of the article, based on the 2004 European Social Survey, is to test these two hypotheses by examining national variation regarding mean levels and class differences in autonomy among 21 countries. The main conclusion is that both mean levels and class differences in autonomy have much more to do with the strength of organized labour than with the skill requirements of production. The analysis also questions a central element of the varieties of capitalism theory, namely the notion of national production strategies based on differences in skill specificity.
Impaired orientation processing in hemispatial neglect

Patients with hemispatial neglect show deficits in size perception. We investigated how this effect would be modulated by a change in object orientation. Seven right-hemisphere-lesioned patients, with and without neglect, and a control group, were asked to indicate which one of two bilaterally presented lines was longer, shorter or the same. Depending on the participant's response, the length was increased or decreased in a staircase-like procedure. Line orientation was varied over separate blocks. All neglect patients judged a line on the left as shorter, predominantly for horizontal lines and lines rotated by 30°. Moreover, the magnitude of the distortion effect varied considerably between patients from as little as 2% objective underestimation to as much as 20%.
Animating bubble interactions in a liquid foam

Bubbles and foams are important features of liquid surface phenomena, but they are difficult to animate due to their thin films and complex interactions in the real world. In particular, small bubbles (having diameter <1cm) in a dense foam are highly affected by surface tension, so their shapes are much less deformable compared with larger bubbles. Under this small bubble assumption, we propose a more accurate and efficient particle-based algorithm to simulate bubble dynamics and interactions. The key component of this algorithm is an approximation of foam geometry, by treating bubble particles as the sites of a weighted Voronoi diagram. The connectivity information provided by the Voronoi diagram allows us to accurately model various interaction effects among bubbles. Using Voronoi cells and weights, we can also explicitly address the volume loss issue in foam simulation, which is a common problem in previous approaches. Under this framework, we present a set of bubble interaction forces to handle miscellaneous foam behaviors, including foam structure under Plateau's laws, clusters formed by liquid surface bubbles, bubble-liquid and bubble-solid coupling, bursting and coalescing. Our experiment shows that this method can be straightforwardly incorporated into existing liquid simulators, and it can efficiently generate realistic foam animations, some of which have never been produced in graphics before.
Integrating extra knowledge into word embedding models for biomedical NLP tasks

Word embedding in the NLP area has attracted increasing attention in recent years. The continuous bag-of-words model (CBOW) and the continuous Skip-gram model (Skip-gram) have been developed to learn distributed representations of words from a large amount of unlabeled text data. In this paper, we explore the idea of integrating extra knowledge to the CBOW and Skip-gram models and applying the new models to biomedical NLP tasks. The main idea is to construct a weighted graph from knowledge bases (KBs) to represent structured relationships among words/concepts. In particular, we propose a GCBOW model and a GSkip-gram model respectively by integrating such a graph into the original CBOW model and Skip-gram model via graph regularization. Our experiments on four general domain standard datasets show encouraging improvements with the new models. Further evaluations on two biomedical NLP tasks (biomedical similarity/relatedness task and biomedical Information Retrieval (IR) task) show that our methods have better performance than baselines.
Stress enhances the consolidation of extinction memory in a predictive learning task

Extinction is not always permanent, as indicated by several types of recovery effects, such as the renewal effect, which may occur after a context change and points towards the importance of contextual cues. Strengthening the retrieval of extinction memory is a crucial aim of extinction-based psychotherapeutic treatments of anxiety disorders to prevent relapse. Stress is known to modulate learning and memory, with mostly enhancing effects on memory consolidation. However, whether such a consolidation-enhancing effect of acute stress can also be found for extinction memory has not yet been examined in humans. In this study, we investigated the effect of stress after extinction learning on the retrieval of extinction memory in a predictive learning renewal paradigm. Participants took the part of being the doctor of a fictitious patient and learned to predict whether certain food stimuli were associated with “stomach trouble” in two different restaurants (contexts). On the first day, critical stimuli were associated with stomach trouble in context A (acquisition phase). On the second day, these associations were extinguished in context B. Directly after extinction, participants were either exposed to a stressor (socially evaluated cold pressor test; n = 22) or a control condition (n = 24). On the third day, we tested retrieval of critical associations in contexts A and B. Participants exposed to stress after extinction exhibited a reduced recovery of responding at test in context B, suggesting that stress may context-dependently enhance the consolidation of extinction memory. Furthermore, the increase in cortisol in response to the stressor was negatively correlated with the recovery of responding in context A. Our findings suggest that in parallel to the known effects of stress on the consolidation of episodic memory, stress also enhances the consolidation of extinction memory, which might be relevant for potential applications in extinction-based psychotherapy.
Strain imaging using conventional and ultrafast ultrasound imaging: numerical analysis

In elasticity imaging, the ultrasound frames acquired during tissue deformation are analyzed to estimate the internal displacements and strains. If the deformation rate is high, high-frame-rate imaging techniques are required to avoid the severe decorrelation between the neighboring ultrasound images. In these high-frame-rate techniques, however, the broader and less focused ultrasound beam is transmitted and, hence, the image quality is degraded. We quantitatively compared strain images obtained using conventional and ultrafast ultrasound imaging methods. The performance of the elasticity imaging was evaluated using custom-designed, numerical simulations. Our results demonstrate that signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and spatial resolutions in displacement and strain images acquired using conventional and ultrafast ultrasound imaging are comparable. This study suggests that the high-frame-rate ultrasound imaging can be reliably used in elasticity imaging if frame rate is critical
Agency and communion are inferred from actions serving interests of self or others

Agentic qualities are associated with self-interests of the trait possessor and communal qualities are associated with interests of other people (with whom the trait possessor interacts with). Based on this idea we hypothesized that information on behavior serving self-interests leads to inferences of agency while information on identical actions performed in the service of others' interests leads to inferences of communion. These hypotheses were supported in a study where participants perceived a politician who acted for or against his own interest and (orthogonally) acted for or against interests of other people. Additionally, actions serving other-interest influenced attitudes toward the politician to a higher degree than actions serving his self-interest. The other-interest influence on attitudes was mediated by inferences of communal qualities of the politician while the self-interest influence on attitudes was mediated by inferences of agentic qualities of the politician. Copyright © 2008 John Wiley & Sons, Ltd.
An evaluation of multiple exemplar instruction to teach perspective-taking skills to adolescents with Asperger Syndrome

The goal of this study was to investigate the effects of multiple exemplar instruction for teaching perspectivetaking skills to young adults with autism. Using a multiple probe design, participants were trained and tested using protocols evaluating the deictic frames of I-You, Here-There, and Now-Then. Generalization of perspectivetaking skills was evaluated using two standardized assessments designed to evaluate theory of mind, which were administered at pre and posttest. Generalization of perspective-taking skills to a more natural language situation was also assessed. Results showed the emergence of perspective-taking for all participants following multiple exemplar instruction, and varying degrees of generalization of perspective-taking skills to a natural presentation of social interaction were observed based on the complexity of the perspective-taking relation.
Tobacco Smoking Surveillance: Is Quota Sampling an Efficient Tool for Monitoring National Trends? A Comparison with a Random Cross-Sectional Survey

Objectives It is crucial for policy makers to monitor the evolution of tobacco smoking prevalence. In France, this monitoring is based on a series of cross-sectional general population surveys, the Health Barometers, conducted every five years and based on random samples. A methodological study has been carried out to assess the reliability of a monitoring system based on regular quota sampling surveys for smoking prevalence. Design / Outcome Measures In 2010, current and daily tobacco smoking prevalences obtained in a quota survey on 8,018 people were compared with those of the 2010 Health Barometer carried out on 27,653 people. Prevalences were assessed separately according to the telephone equipment of the interviewee (landline phone owner vs “mobile-only”), and logistic regressions were conducted in the pooled database to assess the impact of the telephone equipment and of the survey mode on the prevalences found. Finally, logistic regressions adjusted for sociodemographic characteristics were conducted in the random sample in order to determine the impact of the needed number of calls to interwiew “hard-to-reach” people on the prevalence found. Results Current and daily prevalences were higher in the random sample (respectively 33.9% and 27.5% in 15-75 years-old) than in the quota sample (respectively 30.2% and 25.3%). In both surveys, current and daily prevalences were lower among landline phone owners (respectively 31.8% and 25.5% in the random sample and 28.9% and 24.0% in the quota survey). The required number of calls was slightly related to the smoking status after adjustment for sociodemographic characteristics. Conclusion Random sampling appears to be more effective than quota sampling, mainly by making it possible to interview hard-to-reach populations.
A case for toggle-aware compression for GPU systems

Data compression can be an effective method to achieve higher system performance and energy efficiency in modern data-intensive applications by exploiting redundancy and data similarity. Prior works have studied a variety of data compression techniques to improve both capacity (e.g., of caches and main memory) and bandwidth utilization (e.g., of the on-chip and off-chip interconnects). In this paper, we make a new observation about the energy-efficiency of communication when compression is applied. While compression reduces the amount of transferred data, it leads to a substantial increase in the number of bit toggles (i.e., communication channel switchings from 0 to 1 or from 1 to 0). The increased toggle count increases the dynamic energy consumed by on-chip and off-chip buses due to more frequent charging and discharging of the wires. Our results show that the total bit toggle count can increase from 20% to 2.2x when compression is applied for some compression algorithms, averaged across different application suites. We characterize and demonstrate this new problem across 242 GPU applications and six different compression algorithms. To mitigate the problem, we propose two new toggle-aware compression techniques: Energy Control and Metadata Consolidation. These techniques greatly reduce the bit toggle count impact of the data compression algorithms we examine, while keeping most of their bandwidth reduction benefits.