Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential Expression of Two Glial Glutamate Transporters in the Rat Brain: an In Situ Hybridization Study

The distributions of the mRNAs encoding the l‐glutamate transporters GLT1 and GLAST were examined in the rat brain by in situ hybridization using 35S‐labelled oligonucleotide probes. Probes directed to GLT1 produced dense labelling in the hippocampus, neocortex and neostriatum, and weak labelling in the cerebellum. In contrast, GLAST mRNA appeared to be greatly enriched in the cerebellum compared to other brain regions. While the intensity of the labelling for GLAST and GLT1 varied among different regions, their cellular distributions appeared to coincide inasmuch as both mRNAs were mainly expressed by glial cells. Labelling occurred, inter alia, in glial cells throughout the hippocampus, and in Golgi epithelial cells in the Purkinje cell layer of the cerebellum.
N ° 2017 – 45 Production Efficiency and Profit Taxation

Consider a simple general equilibrium economy with one representative consumer, a single competitive firm and the government. Suppose that the government has to finance public expenditures using linear consumption taxes and/or a lump-sum tax on profits redistributed to the consumer. This note shows that, if the tax rate on profits cannot exceed 100 percent, one cannot improve upon the second-best optimum of an economy with constant returns to scale by using a less efficient profit-generating decreasing returns to scale technology. JEL classification numbers: H21
A New Method for Incremental Testing of Finite State Machines

The automatic generation of test cases is an important issuefor conformance testing of several critical systems. We present a new method for the derivationof test suites when the specification is modeled as a combined Finite State Machine (FSM). A combinedFSM is obtained conjoining previously tested submachineswith newly addedstates. This new concept is used to describe a fault model suitable for incremental testing of new systems, or for retesting modified implementations. For this fault model, only the newly added or modified states need to betested, thereby considerablyreducing the size of the test suites. The new method is a generalization of the well-known W-method [4] and the G-method [2], but is scalable, and so it can be used to testFSMs with an arbitrarily large number of states.
Visual Prediction in Infancy: What is the Association with Later Vocabulary?

Young infants can learn statistical regularities and patterns in sequences of events. Studies have demonstrated a relationship between early sequence learning skills and later development of cognitive and language skills. We investigated the relation between infants’ visual response speed to novel event sequences, and their later receptive and productive vocabulary. Using a modified visual expectancy paradigm (VExP; Haith, Wentworth, & Canfield, 1993), we tested 6-month-old infants’ speed at responding to novel but predictable contingent event sequences. In addition, parental reports and behavioral measures of infants’ vocabulary were obtained at 12, 16, and 22 months. In order to estimate the separate effects of linguistic input on vocabulary, maternal speech from a play session at 12 months was analyzed for lexical diversity and quantity. Results suggest that infants’ speed of responding to novel but predictable events at 6 months robustly predicted both receptive and productive vocabulary at 22 months. This relation cannot be attributed to general cognitive maturity, as measured by a standardized test (Bayley Scales of Infant Development; Bayley, 2005). Maternal input predicted additional unique variance in infant processing speed. The results suggest that infants’ capacity to quickly learn and respond to sequential patterns, over and above the quality of the speech input they receive, contributes to vocabulary size in the second year.
Technology Transfer and the Economic Implications of the Strengthening of Intellectual Property Rights in Developing Countries

This paper presents an empirical analysis of the influence of the strength of intellectual property rights (IPRs) on technology transfer to developing nations. The core contribution is to use regression analysis to examine the relationship between various measures of technology transfer and a set of indexes that quantify the strength of IPRs based on laws on the books, while controlling for other factors. For this purpose, the authors have assembled a data set covering a broad international panel of countries for an expanded time frame (1990-2005) in comparison with previous studies on IPRs by the Trade and Agriculture Directorate. Regression analysis is also used to assess the relationship between measures of local innovation and the IPR indexes. The study employs case study analysis of select countries - namely the BRIC countries (Brazil, Russia, India, and China) - to complement the statistical analysis.
Urethane anesthesia depresses activities of thalamocortical neurons and alters its response to nociception in terms of dual firing modes

Anesthetics are often used to characterize the activity of single neurons in vivo for their advantages such as reduction of noise level and convenience in noxious stimulations. Urethane has been a widely used anesthetic in thalamic studies under the assumption that sensory signals are still relayed to the thalamus under urethane anesthesia and that thalamic response would therefore reflect the response of the awake state. We tested this assumption by comparing thalamic activity in terms of tonic and burst firing modes during “the awake state” or under “urethane anesthesia” using the extracellular single unit recording technique. We first tested how thalamic relay neurons respond to the introduction of urethane, and then tested how urethane influences thalamic discharges under formalin-induced nociception. Urethane significantly depressed overall firing rates of thalamic relay neurons, which was sustained despite the delayed increase of burst activity over a 4 h recording period. Thalamic response to nociception under anesthesia was also similar overall except for the slight and transient increase of burst activity. Overall, results demonstrated that urethane suppresses the activity of thalamic relay neurons and that, despite the slight fluctuation of burst firing, formalin-induced nociception cannot significantly change the firing pattern of thalamic relay neurons that was caused by urethane.
Impact of JIT and TQM Strategies on Searching for Health Information and Ensuring Service Quality in Hospitals

This investigation analytically and empirically the effects of just-in-time (JIT) and total quality management (TQM ) strategies on searching for health information and the quality of hospital service, and analyzes the steps that are involved in knowledge management that are required to improve the quality of service in a hospital. The final section of this investigation proposes that effectively promoting total quality management activities requires managers to evaluate, and to improve the convenience of systems for searching health information. The results also indicate that the JIT strategy is directly positively related to the effectiveness of searches for health information and the quality of service at a hospital, and that a positive relationship exists between the TQM strategy, searching for information and quality of service in all instances.
PASS: A Dutch data-to-text system for soccer, targeted towards specific audiences

We present PASS, a data-to-text system that generates Dutch soccer reports from match statistics. One of the novel elements of PASS is the fact that the system produces corpus-based texts tailored towards fans of one club or the other, which can most prominently be observed in the tone of voice used in the reports. Furthermore, the system is open source and uses a modular design, which makes it relatively easy for people to add extensions. Human-based evaluation shows that people are generally positive towards PASS in regards to its clarity and fluency, and that the tailoring is accurately recognized in most cases.
SHOCK-INDUCED SEPARATED STRUCTURES IN SYMMETRIC CORNER FLOWS

Three-dimensional supersonic viscous laminar flows over symmetric corners are considered in this paper. The characteristic features of such configurations are discussed and an historical survey on the past research work is presented. A new contribution based on a numerical technique that solves the parabolized form of the Navier-Stokes equations is presented. Such a method makes it possible to obtain very detailed descriptions of the flowfield with relatively modest CPU time and memory storage requirements. The numerical approach is based on a space-marching technique, uses a finite volume discretization and an upwind flux-difference splitting scheme (developed for the steady flow equations) for the evaluation of the inviscid fluxes. Second order accuracy is reached following the guidelines of the ENO schemes. Different free-stream conditions and geometrical configurations are considered. Primary and secondary streamwise vortical structures embedded in the boundary layer and originated by the interaction of the latter with shock waves are detected and studied. Computed results are compared with experimental data taken from literature.
Evolution of the X‐ray luminosity in young H ii galaxies★

In an effort to understand the correlation between X-ray emission and present star formation rate, we obtained XMM-Newton data to estimate the X-ray luminosities of a sample of actively star-forming H II galaxies. The obtained X-ray luminosities are compared to other well-known tracers of star formation activity such as the far-infrared and the ultraviolet luminosities. We also compare the obtained results with empirical laws from the literature and with recently published analysis applying synthesis models. We use the time delay between the formation of the stellar cluster and that of the first X-ray binaries, in order to put limits on the age of a given stellar burst. We conclude that the generation of soft X-rays, as well as the Hα or infrared luminosities is instantaneous. The relation between the observed radio and hard X-ray luminosities, on the other hand, points to the existence of a time delay between the formation of the stellar cluster and the explosion of the first massive stars and the consequent formation of supernova (SN) remnants and high-mass X-ray binaries, which originate the radio and hard X-ray fluxes, respectively. When comparing hard X-rays with a star formation indicator that traces the first million years of evolution (e.g. Hα luminosities), we found a deficit in the expected X-ray luminosity. This deficit is not found when the X-ray luminosities are compared with infrared luminosities, a star formation tracer that represents an average over the last 10 8 yr. The results support the hypothesis that hard X-rays are originated in X-ray binaries which, as SN remnants, have a formation time delay of a few mega years after the star-forming burst.
Robust X-band low noise limiting amplifiers

GaN technology is today well established for power amplifiers but also for robust receiver components. In this paper we present the design and measurement results of two different robust LNAs with different limiter functionalities included. One version with 1.6 dB noise figure which survives 4W input power and with the included current limiter the maximum output power is only 17dBm. The other version with input limiter survives more than 10W input power with a noise figure of 2 dB.
The Jump-Risk Premia Implicit in Options : Evidence from an Integrated Time-Series Study

This paper examines the joint time series of the S&P 500 index and near-the-money short-dated option prices with an arbitrage-free model, capturing both stochastic volatility and jumps. Jump-risk premia uncovered from the joint data respond quickly to market volatility, becoming more prominent during volatile markets. This form of jump-risk premia is important not only in reconciling the dynamics implied by the joint data, but also in explaining the volatility “smirks” of cross-sectional options data. ∗MIT Sloan School of Management, 50 Memorial Drive, Cambridge, MA 02142. Email: junpan@mit.edu. I benefited from discussions with professors and doctoral students in the finance program at Stanford. I am especially grateful to my advisers, Darrell Duffie and Ken Singleton, who inspired me to take on this project, and helped with their insightful comments and warm encouragement. I also benefited from extensive discussions with Jun Liu, as well as comments from two anonymous referees, Andrew Ang, David Bates, Joe Chen, Mark Ferguson, Peter Glynn, Harrison Hong, Ming Huang, Mike Johannes, George Papanicolaou, Monika Piazzesi, Tom Sargent, and seminar participants at Stanford, Berkeley, MIT, UCLA, HBS, Rochester, Wisconsin Madison, Michigan, Duke, Kellogg, Chicago, Columbia, the Stanford Financial Engineering Workshop, Cornell, Minnesota, the Conference on Risk Neutral and Objective Probability Distributions, Boston College, and the 2001 AFA meetings. This paper was previously circulated as “Integrated Time-Series Analysis of Spot and Option Prices. ” It can be downloaded from www.mit.edu/~junpan/.
Improving Statistical Machine Translation with Monolingual Collocation

This paper proposes to use monolingual collocations to improve Statistical Machine Translation (SMT). We make use of the collocation probabilities, which are estimated from monolingual corpora, in two aspects, namely improving word alignment for various kinds of SMT systems and improving phrase table for phrase-based SMT. The experimental results show that our method improves the performance of both word alignment and translation quality significantly. As compared to baseline systems, we achieve absolute improvements of 2.40 BLEU score on a phrase-based SMT system and 1.76 BLEU score on a parsing-based SMT system.
Venn sampling: a novel prediction technique for moving objects

Given a region q/sub R/ and a future timestamp q/sub T/, a "range aggregate" query estimates the number of objects expected to appear in q/sub R/ at time q/sub T/. Currently the only methods for processing such queries are based on spatio-temporal histograms, which have several serious problems. First, they consume considerable space in order to provide accurate estimation. Second, they incur high evaluation cost. Third, their efficiency continuously deteriorates with time. Fourth, their maintenance requires significant update overhead. Motivated by this, we develop Venn sampling (VS), a novel estimation method optimized for a set of "pivot queries" that reflect the distribution of actual ones. In particular, given m pivot queries, VS achieves perfect estimation with only O(m) samples, as opposed to O(2/sup m/) required by the current state of the art in workload-aware sampling. Compared with histograms, our technique is much more accurate (given the same space), produces estimates with negligible cost, and does not deteriorate with time. Furthermore, it permits the development of a novel "query-driven" update policy, which reduces the update cost of conventional policies significantly.
Hyperacusis in Williams syndrome

Background: Hyperacusis and phonophobia are common, debilitating symptoms in Williams syndrome (WS), yet little is known about their underlying audiologic and neurologic processes. Methods: The mothers of 49 subjects with WS were asked to complete the Hyperacusis Screening Questionnaire. Subjects with reported hyperacusis and sufficient developmental capacity underwent comprehensive audiological and brain auditory evoked response (BAER) testing. Findings were compared with those from pair-matched typically developing control subjects. Results: Forty-one of the 49 children with WS (84%) had hyperacusis of moderate to severe degree, which began in infancy. Of these, 21 (mean age 15.8 ± 5.5 years) were quantitatively tested. Subjects with WS reported discomfort at sound intensities on average 20 dB lower than control subjects. Pure-tone audiometry and distortion products otoacoustic emission test revealed a high-frequency cochlear hearing loss. An absence of ipsilateral acoustic reflex responses to maximum stimulation was significantly more common in the subjects with WS than controls. On BAER testing, the WS group had a significant prolongation in wave I latency. Conclusions: Hyperacusis in Williams syndrome (WS) is associated with a high-frequency hearing loss resembling the configuration of noise-induced hearing loss. The hyperacusis and hearing loss in WS may stem from a deficiency in the acoustic reflex resulting from auditory nerve dysfunction. Additional mechanisms that may mediate hyperacusis in WS and should be evaluated in future studies include recruitment, malformation of the facial canal, and haploinsufficiency of the elastin gene.
Prevention of cardiovascular events with antiplatelet treatment: does time of intake matter for aspirin and ADP receptor blockers?

Summary Long-term evidence supports a clustering of cardiovascular events in the early morning. Several studies have shown that platelet hyper-reactivity to various stimuli is also present at this period of the day. However, the idea of treatment strategies reflecting the circadian variation in platelet reactivity has been largely neglected so far, and this is true despite the huge number of patients being treated with these drugs. Some pharmacodynamic data suggest that early-morning platelet hyper-reactivity may be overcome by shifting aspirin intake to the bedtime. However, there is lack of evidence whether shifting the time of intake or splitting the daily dose of P2Y12-inhibitors with a regular QD dosing (clopidogrel or prasugrel) to the evening would be effective to overcome platelet hyper-reactivity or to suppress the excess of cardiovascular events observed during morning hours. Further research is warranted to clarify whether such a simple and costless effort like dose shifting or splitting may be beneficial to prevent cardiovascular events.
Single-cell gene expression analysis reveals regulators of distinct cell subpopulations among developing human neurons

The stochastic dynamics and regulatory mechanisms that govern differentiation of individual human neural precursor cells (NPC) into mature neurons are currently not fully understood. Here, we used single-cell RNA-sequencing (scRNA-seq) of developing neurons to dissect/identify NPC subtypes and critical developmental stages of alternative lineage specifications. This study comprises an unsupervised, high-resolution strategy for identifying cell developmental bifurcations, tracking the stochastic transcript kinetics of the subpopulations, elucidating regulatory networks, and finding key regulators. Our data revealed the bifurcation and developmental tracks of the two NPC subpopulations, and we captured an early (24 h) transition phase that leads to alternative neuronal specifications. The consequent up-regulation and down-regulation of stage- and subpopulation-specific gene groups during the course of maturation revealed biological insights with regard to key regulatory transcription factors and lincRNAs that control cellular programs in the identified neuronal subpopulations.
Functional Modules in the Arabidopsis Core Cell Cycle Binary Protein–Protein Interaction Network[W]

This study describes the creation of a binary protein–protein interaction map of core cell cycle proteins of Arabidopsis thaliana using two complementary interaction assays, yeast two-hybrid and bimolecular fluorescence complementation. It integrates this map with expression data and describes 357 protein–protein interactions, of which 293 are previously unreported. As in other eukaryotes, cell division in plants is highly conserved and regulated by cyclin-dependent kinases (CDKs) that are themselves predominantly regulated at the posttranscriptional level by their association with proteins such as cyclins. Although over the last years the knowledge of the plant cell cycle has considerably increased, little is known on the assembly and regulation of the different CDK complexes. To map protein–protein interactions between core cell cycle proteins of Arabidopsis thaliana, a binary protein–protein interactome network was generated using two complementary high-throughput interaction assays, yeast two-hybrid and bimolecular fluorescence complementation. Pairwise interactions among 58 core cell cycle proteins were tested, resulting in 357 interactions, of which 293 have not been reported before. Integration of the binary interaction results with cell cycle phase-dependent expression information and localization data allowed the construction of a dynamic interaction network. The obtained interaction map constitutes a framework for further in-depth analysis of the cell cycle machinery.
Characterization of the combustion products in large‐scale fire tests: comparison of three experimental configurations

The storage of large amounts of polymers and other bulk chemicals is a potential hazard in the case of fire. There is at present a lack of knowledge about the implications of such fires. In particular the role of the ventilation conditions on fire chemistry has warranted investigation. A set of indoor, large‐scale combustion experiments, conducted on five different materials is described in this article. The main test series was conducted using the ISO 9705 room, where both well‐ventilated and under‐ventilated conditions were attained by restricting the opening of the room. The degree of ventilation was determined using a phi meter. Furthermore, in addition to measuring the traditional fire‐related parameters, extensive chemical characterization of the combustion products was made.
Clinical and Genetic Aspects in Patients with Idiopathic Parkinson Disease

Parkinson syndrome is one of the most often neurodegenerative diseases, which affects the Central Nervous system. James Parkinson was the first who described the clinical symptoms of factor complex, a complex which can be present as a combination of six cardinal signs: tremor, rigor, bradikinesia-hypokinesia, curve pose, lose of postural reflexes and freezing phenomena. To get to the final diagnose, the clinicians usually use the Brain Bank Criteria of UKPDS [9]. Generally, there are four categories of Parkinsonism: Idiopathic Parkinson Disease; Secondary Parkinsonism; Parkinson plus syndrome and other neurodegenerative diseases in which Parkinsonism is main clinical manifestation [7]. Idiopathic Parkinson disease is the most represented type of Parkinsonism and it is maintained in almost 80 percents of the patients with movement disorders. Mostly with unilateral presentation, well respons on Dopamine-agonists and Levodopa, characterized with general slowness and typical tremor, from 4 to 6 Herz. The basic patho-anatomical findings in patients with Idiopathic Parkinson Disease, is loss of neurons which contain neuromelanin. These neurons are located in particular parts of the brain, such as substantia nigra and locus ceruleus. Dopamine level is reduced for almost 80 percents under normal level, especially in striatum [7]. Hystopatological findings direct to presence of intracellular inclusions called Lewy-body, primary in substantia nigra, and they contain alpha-synuclein. Alpha-synuclein is present in many parts of the brain, but mostly in substantia nigra, and it is the only synuclein included in Parkinson disease. It was found that two non-sence mutations in gene of alpha-synuclein, A53T and A30P, are closely related with early appearance of Idiopathic Parkinson Disease between populations in Europe. Accumulation of this protein in dopaminergic neurons is responsible for the process of neurodegeneration [20].