Miracle-dz/UniFAR-FTUs huggingface dataset:
The Quarterly Journal of Experimental Psychology Section A: Human Experimental Psychology Goal Specificity Effects on Hypothesis Testing in Problem Solving

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Is reduction in the risk of vision loss the only benefit of photodynamic therapy in predominantly classic subfoveal choroidal neovascularization?

Purpose To emphasize the effect of photodynamic therapy (PDT) on the size and progression of the neovascular lesion (NL) and evolution of the disciform scar (DS) in predominantly classic subfoveal choroidal neovascularization (SFCNV). Methods A retrospective study of 62 eyes treated with PDT for SFCNV was performed. The greatest linear dimension (GLD) before and at last follow-up after treatment and the size of the DS post-PDT were analyzed. A subgroup of patients with DS in their fellow eye at presentation without prior PDT was also studied. The size of the scar in these eyes was compared to that following PDT. Results After an average follow-up at 9 months, the size of the NL was stabilized or reduced in 64% of the study eyes with absence of fluorescein leakage in 45%. Only 3 eyes (5%) developed DS. At presentation, 14 patients already had DS in their fellow eye, the size of which was significantly larger than that post-PDT (p = 0.044). It was also significantly larger than that of the potential scar in the study eyes of the same subgroup of patients (p = 0.002) and of the rest of the patients (p = 0.0001). Conclusion This study demonstrates a beneficial effect for PDT on the size of the NL and DS in SFCNV, which might be of great significance, particularly when PDT fails to prevent severe vision loss.
Functional Characterization of Streptococcal Pyrogenic Exotoxin J, a Novel Superantigen

ABSTRACT Streptococcal toxic shock syndrome (STSS) is a highly lethal, acute-onset illness that is a subset of invasive streptococcal disease. The majority of clinical STSS cases have been associated with the pyrogenic toxin superantigens (PTSAgs) streptococcal pyrogenic exotoxin A or C (SPE A or C), although cases have been reported that are not associated with either of these exotoxins. Recent genome sequencing projects have revealed a number of open reading frames that potentially encode proteins with similarity to SPEs A and C and to other PTSAgs. Here, we describe the cloning, expression, purification, and functional characterization of a novel exotoxin termed streptococcal pyrogenic exotoxin J (SPE J). Purified recombinant SPE J (rSPE J) expressed fromEscherichia coli stimulated the expansion of both rabbit splenocytes and human peripheral blood lymphocytes, preferentially expanded human T cells displaying Vβ2, -3, -12, -14, and -17 on their T-cell receptors, and was active at concentrations as low as 5 × 10−6 μg/ml. Furthermore, rSPE J induced fevers in rabbits and was lethal in two models of STSS. Biochemically, SPE J had a predicted molecular weight of 24,444 and an isoelectric point of 7.7 and lacked the ability to form the cystine loop structure characteristic of many PTSAgs. SPE J shared 19.6, 47.1, 38.8, 18.1, 19.6, and 24.4% identity with SPEs A, C, G, and H, streptococcal superantigen, and streptococcal mitogenic exotoxin Z-2, respectively, and was immunologically cross-reactive with SPE C. The characterization of a seventh functional streptococcal PTSAg raises important questions relating to the evolution of the streptococcal superantigens.
An Empirical Security Study of the Native Code in the JDK

It is well known that the use of native methods in Java defeats Java's guarantees of safety and security, which is why the default policy of Java applets, for example, does not allow loading non-local native code. However, there is already a large amount of trusted native C/C++ code that comprises a significant portion of the Java Development Kit (JDK). We have carried out an empirical security study on a portion of the native code in Sun's JDK 1.6. By applying static analysis tools and manual inspection, we have identified in this security-critical code previously undiscovered bugs. Based on our study, we describe a taxonomy to classify bugs. Our taxonomy provides guidance to construction of automated and accurate bug-finding tools. We also suggest systematic remedies that can mediate the threats posed by the native code.
Prospects for antiviral ribozymes and deoxyribozymes

Ribozymes and deoxyribozymes (collectively referred to as nucleic acid enzymes) can be designed to cleave substrate mRNAs in a sequence‐specific manner, and thus represent a potentially important tool to inhibit selectively the expression of deleterious genes. Nucleic acid enzymes can be delivered to cells either as genes encoding RNA enzymes (ribozymes), or exogenously as in vitro produced agents. This review focuses in particular on the ‘exogenous application’ of ribozymes and deoxyribozymes as antiviral drugs.
Espaces-ressources-usages : spatialisation des interactions dynamiques entre les systèmes sociaux et les systèmes écologiques au Sahel nigérien

L'objectif de ce travail etait de comprendre la structure et la dynamique des paysages et se donner les moyens de pronostiquer leur evolution. Cette etude a ete abordee a travers une approche de la dynamique et de la spatialisation des interactions entre les systemes ecologiques et sociaux, centree sur la dynamique entre ressources et usages. Les travaux ont conduit a differencier et proposer desmethodes pour caracteriser d'une part, a partir d'images aeriennes et satellitales, des espaces paysagers (unites paysageres), soumis a des facteurs biophysiques et a l'utilisation passee et actuelle des terres, et d'autre part, par modelisation, des espaces de pratiques homogenes (unites de pratiques homogenes) traduisant les modes d'intervention des societes rurales sur leur milieu. La confrontation de ces deux espaces conduit a definir des unites spatiales de reference, sur lesquelles sont quantifiees simultanement la nature et la quantite de ressources produites, ainsi que la nature et l'intensite des prelevements operes par les populations. Une approche modulaire par grand type d'utilisation des terres (agricole, pastorale et forestiere) a permis d'etablir des bilans spatialises pourchacun des modules, leur confrontation aboutissant a la comprehension des paysages actuels, a travers un bilan global multi-usage. Cette approche systemique a ete integree dans un systeme d'information sur l'environnement. Ce programme de recherche a ete conduit sur le site de banizoumbou au niger, sur lequel sont intervenues de nombreuses equipes de l'orstom, agronomes, pedologues et hydrologues, en collaboration avec l'equipe de m. D'herbes, phyto-ecologue a l'orstom. Les developpements informatiques ont ete realises en collaboration avec m. Gayte, actuellement a esrifrance.
The Restless Multi-Armed Bandit Formulation of the Cognitive Compressive Sensing Problem

In this paper we introduce the Cognitive Compressive Sensing (CCS) problem, modeling a Cognitive Receiver (CR) that optimizes the K projections of a N > K dimensional vector dynamically, by optimizing the objective of correctly detecting the maximum number of idle entries, while updating each time its Bayesian beliefs on the future vector realizations. We formulate and study the CCS as a Restless Multi-Armed Bandit problem, generalizing the popular Cognitive Spectrum Sensing model, in which the CR can sense K out of the N sub-channels and propose a novel adaptive Finite Rate of Innovation (FRI) sampling method based on the CCS approach. While in general the optimum policy remains elusive, we provide sufficient conditions in which in the limit for large K and N the greedy policy is optimum. Numerical results corroborate our theoretical findings.
Cost-Conscious Strategies to Increase Performance of Numerical Programs on Aggressive VLIW Architectures

Loops are the main time-consuming part of numerical applications. The performance of the loops is limited either by the resources offered by the architecture or by recurrences in the computation. To execute more operations per cycle, current processors are designed with growing degrees of resource replication (replication technique) for memory ports and functional units. However, the high cost in terms of area and cycle time of this technique precludes the use of high degrees of replication. High values for the cycle time may clearly offset any gain in terms of number of execution cycles. High values for the area may lead to an unimplementable configuration. An alternative to resource replication is resource widening (widening technique), which has also been used in some recent designs in which the width of the resources is increased (i.e., a single operation is performed over multiple data). Moreover, several general-purpose superscalar microprocessors have been implemented with multiply-add fused floating-point units (fusion technique), which reduces the latency of the combined operation and the number of resources used. The authors evaluate a broad set of VLIW processor design alternatives that combine the three techniques. We perform a technological projection for the next processor generations in order to foresee the possible implementable alternatives. From this study, we conclude that if the cost is taken into account, combining certain degrees of replication and widening in the hardware resources is more effective than applying only replication. Also, we confirm that multiply-add fused units will have a significant impact in raising the performance of future processor architectures with a reasonable increase in cost.
Outcome of EGFR-mutated NSCLC patients with MET-driven resistance to EGFR tyrosine kinase inhibitors

Background Several mechanisms of acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) in EGFR-mutated NSCLC have been described including the T790M mutation and MET amplification. Whereas T790M mutation confers prolonged survival and sensitivity to 3rd generation TKIs, data are lacking on clinical features and outcome of MET-driven resistant EGFR-mutated NSCLC patients. Methods Patients with metastatic EGFR-mutated NSCLC displaying high MET overexpression or MET amplification, detected on a biopsy performed after progression on EGFR TKI, were identified in 15 centers. Clinical and molecular data were retrospectively collected. Results Forty two patients were included. The median overall survival (OS), and the median post EGFR TKI progression overall survival (PPOS) were 36.2 months [95%CI 27.3-66.5] and 18.5 months [95%CI 10.6-27.4] respectively. Nineteen out of 36 tumors tested for MET FISH had MET amplification. A T790M mutation was found in 11/41 (26.8%) patients. T790M-positive patients had a better OS than T790M-negative patients (p=0.0224). Nineteen patients received a MET TKI. Objective response was reported in 1 out of 12 evaluable patients treated with a MET inhibitor as a single agent and in 1 of 2 patients treated with a combination of MET and EGFR TKIs. Conclusion MET-driven resistance to EGFR TKI defines a specific pattern of resistance characterized by low objective response rate to MET inhibitors given alone and overlapping with T790M mutations. Further studies are warranted to define adequate therapeutic strategies for MET-driven resistance to EGFR TKI.
The delineation of an interdisciplinary specialty in terms of a journal set: The case of communication studies

A journal set in an interdisciplinary or newly developing area can be determined by including the journals classified under the most relevant ISI Subject Categories into a journal-journal citation matrix. Despite the fuzzy character of borders, factor analysis of the citation patterns enables us to delineate the specific set by discarding the noise. This methodology is illustrated using communication studies as a hybrid development between political science and social psychology. The development can be visualized using animations which support the claim that a specific journal set in communication studies is increasingly developing, notably in the "being cited" patterns. The resulting set of 28 journals in communication studies is smaller and more focused than the 45 journals classified by the ISI Subject Categories as "Communication". The proposed method is tested for its robustness by extending the relevant environments to sets including many more journals.
Males' Support Toward Females After Sexual Assault

The current study explored the relations among rape myths, attitudes toward rape victims, perceived social support, sex role, and social reactions in a male undergraduate sample (N = 205). Males who have provided support to a sexual assault victim were compared to those who have not provided support to a sexual assault victim on several measures. Social reactions of those who have provided support to a sexual assault victim were compared to hypothetical reactions provided by individuals who have not previously provided support. Results indicated that rape related attitudes and beliefs did not differ between those who have and have not provided support to a sexual assault victim. In addition, individuals who were responding to a hypothetical situation reported that they would provide more positive social support than individuals who were responding to an actual situation. Implications for clinical work and future research in this area are discussed.
Reliability and validity of two new instruments for measuring aspects of mental slowness in the daily lives of stroke patients

The objective of the study was to examine psychometric characteristics of two measures related to mental slowness experienced after stroke: One measure is aimed at performance on tasks, the other is a questionnaire evaluating perceived consequences of mental slowness. A group of 37 stroke patients and 33 matched controls were studied. A subgroup of 10 patients and 22 controls was observed by two independent raters to determine inter-rater reliability, a subgroup of 18 patients completed the questionnaire twice over a two-week interval to determine test-retest stability. Results showed that internal consistency was acceptable for the Mental Slowness Observation Test (Cronbach's α = .61 and .73) and good for the Mental Slowness Questionnaire (α = .91). For the Observation Test, correlations between the results of the two raters ranged between . 77 and . 99 and intra-class correlation coefficients were between . 86 and . 99. For the Questionnaire, correlations between two test occasions ranged between . 85 and . 90 and intra-class correlation coefficients were between . 91 and . 95. Correlations of between . 52 and . 67 were found between the Observation Test and neuropsychological tasks for speed of information processing. The Questionnaire correlated most strongly with scores on tests for activities of daily living (ADL) functioning, and fatigue and depression (correlations ranged between .37 and .63). It was concluded that the two new instruments offer reliable and valid methods for measuring limitations in daily activities related to mental slowness and some of the consequences of mental slowness in terms of sense of time pressure, fatigue, depressive complaints and independent ADL functioning.
Fighting for Life: A Qualitative Analysis of the Process of Psychotherapy-Assisted Self-Help in Patients With Metastatic Cancer

This exploratory study is an attempt to define psychological attributes related to longer survival in patients with meta-static cancers. Previous published analyses have been limited in two ways. First, they have almost always been carried out on patients not receiving therapy; we have followed people receiving a year of group therapy, on the assumption that if mental qualities are to affect cancer progression, substantial mental change would be needed to alter the established balance between the cancer cells and host regulatory mechanisms. Second, the methods typically used to characterize patients’ psychology have been self-report inventories, and many decades of research with such methods have largely failed to produce a consensus on what mental qualities, if any, promote survival. By contrast, we have used qualitative methods, allowing a much more in-depth analysis of the patients, without preliminary assumptions as to what would be important. The present report describes the results of a detailed qualitative analysis of data collected from 22 participants over a year of weekly group therapy. Using grounded methods, categories were derived from the extensive verbal data (comprising patients’ written homework and therapists’ notes), and linked in a model of change. By applying ratings to some of these categories, and combining these ratings, we derived a quantitative estimate of patients’“involvement in self-help. ” Rankings on degree of involvement corresponded quite closely with the quality of patients’ experience and with their survival duration. There was a great range in degree of involvement, and various subgroupings could be discerned. Nine of the participants were classed as “highly involved,” meaning that they devoted regular daily time, often several hours, to such self-help strategies as relaxation, mental imaging, meditation, cognitive monitoring and journalling. All but 1 of these patients enjoyed a good quality of life and lived at least 2 years. Two of them have remained in complete remission for 7 years. At the other end of the scale, 8 patients showed little application to the work, being either unconvinced that it would help them or hampered by psychological problems such as low self-esteem. None of these was rated as having a good quality of life, and only 1 lived more than 2 years, although, as a group, their medicalprognoses were no more unfavorable at the onset of therapy than for the “high in volvement” group. The different subgroups and aspects of the model are illustrated by representative quotations.
A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival

MicroRNAs are small non-coding RNAs with a length of 18–25 nucleotides. They can regulate tumor invasion and metastasis by changing the expression and translation of their target mRNAs. Their expression is substantially altered in colorectal cancer cells as well as in the adjacent tumor-associated stroma. Both of these compartments have a mutual influence on tumor progression. In the development of metastases, cancer cells initially interact with the host tissue. Therefore, compartment-specific expression signatures of these three locations—tumor, associated stroma, and host tissue—can provide new insights into the complex tumor biology of colorectal cancer. Frozen tissue samples of colorectal liver (n = 25) and lung metastases (n = 24) were laser microdissected to separate tumor cells and the adjacent tumor-associated stroma cells. Additionally, normal lung and liver tissue was collected from the same patients. We performed a microarray analysis in four randomly selected liver metastases and four randomly selected lung metastases, analyzing a total of 939 human miRNAs. miRNAs with a significant change >2-fold between the tumor, tumor stroma, and host tissue were analyzed in all samples using RT-qPCR (11 miRNAs) and correlated with the clinical data. We found a differential expression of several miRNAs between the tumor, the tumor-associated stroma, and the host tissue compartment. When comparing liver and lung metastases, miR-194 showed a 1.5-fold; miR-125, miR-127, and miR-192 showed a 2.5-fold; miR-19 and miR-215 a 3-fold; miR-145, miR-199-3, and miR-429 a 5-fold; miR-21 a 7-fold; and, finally, miR-199-5 a 12.5-fold downregulation in liver metastases compared to lung metastases. Furthermore miR-19, miR-125, miR-127, miR-192, miR-194, miR-199-5, and miR-215 showed a significant upregulation in the normal liver tissue compared to the normal lung tissue. Univariate analysis identified an association of poor survival with the expression of miR-125 (p = 0.05), miR-127 (p = 0.001), miR-145 (p = 0.005), miR-192 (p = 0.015), miR-194 (0.003), miR-199-5 (p = 0.008), miR-215 (p < 0.001), and miR-429 (p = 0.03) in the host liver tissue of the liver metastases. Colorectal liver and lung metastases have a unique miRNA expression profile. miRNA expression in the host tissue of colorectal liver metastases seems to be able to influence tumor progression and survival. These findings can be used in the development of tailored therapies.
A Review of Research on Time in Sport Pedagogy

This article provides a representative review of the current literature on time-related research in sport pedagogy. The reviewed studies are presented and discussed in four general areas: how time has been conceptualized, how time has been measured, what is known about how time is spent in physical education and sport settings, and what is still left to be known about time-related events. The final section suggests a six-item agenda for expanding and continuing research on time in sport pedagogy.
Target-dependent Twitter Sentiment Classification

Sentiment analysis on Twitter data has attracted much attention recently. In this paper, we focus on target-dependent Twitter sentiment classification; namely, given a query, we classify the sentiments of the tweets as positive, negative or neutral according to whether they contain positive, negative or neutral sentiments about that query. Here the query serves as the target of the sentiments. The state-of-the-art approaches for solving this problem always adopt the target-independent strategy, which may assign irrelevant sentiments to the given target. Moreover, the state-of-the-art approaches only take the tweet to be classified into consideration when classifying the sentiment; they ignore its context (i.e., related tweets). However, because tweets are usually short and more ambiguous, sometimes it is not enough to consider only the current tweet for sentiment classification. In this paper, we propose to improve target-dependent Twitter sentiment classification by 1) incorporating target-dependent features; and 2) taking related tweets into consideration. According to the experimental results, our approach greatly improves the performance of target-dependent sentiment classification.