Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence and Associated Factors of Depression among PLHIV in Ethiopia: Systematic Review and Meta-Analysis, 2017

Background Depression is a substantial contributor to the global burden of disease and affects people in all communities across the globe. Depression is the most common psychiatric problem associated with HIV/AIDS and half of all PLWHIV with depression go underdiagnosed and untreated. Psychiatric complications of HIVAIDS delay mental health services in less affluent countries. However, there is lack of study with regard to the pooled estimation prevalence of depression in PLWHIV in Ethiopia. Objectives The aim of this systematic review and meta-analysis is to summarize the most current available evidence from 2010 to March 2017 among adult PLWHIV in Ethiopia. Methods The team explored multiple databases searching methods including MEDLINE/PubMed, PsycINFO, Google Advance Scholar, and Google Scholar to find studies published with the data on the prevalence of depression among PLWHIV. We searched 150 research articles; of these 143 articles were excluded. Subsequently, thirteen articles were used for synthesis prevalence and four studies were included in the synthesis effect of sex on depression among PLWHIV. Results The total of pooled estimated prevalence of depression in PLWHIV was 36.65. Estimated prevalence of depression in three studies by using CES-D was 31.19% and in six studies by using PHQ-9 was 37.91%. The remaining four studies used a single tool: Kessler-6 Scale (15.5%), HADS (41.2%), HDSQ (43.9%), and BDI (55.8%). Factors such as age, marital status, living alone, poor medication adherence, poor social support, clinical stages II and III of HIV, stigma, income, and occupation were significantly associated with depression. Conclusions and Recommendation The pooled estimate prevalence of depression among PLWHIV was higher than that in the general population. It is better to offer special attention to these populations.
Comparison of chemoradiotherapy with radiotherapy alone for “biopsy only” anaplastic astrocytoma

Background It has become increasingly common to incorporate adjuvant chemotherapy with radiotherapy in the treatment of resected anaplastic astrocytoma based on results from recent phase II/III randomized trials. However, whether or not combined chemoradiotherapy is associated with improved survival outcome in patients who undergo “biopsy only” is less clear. Methods The US National Cancer Database was used to identify patients with histologically confirmed, biopsy-only anaplastic astrocytoma who received either radiotherapy alone or combined chemoradiotherapy from 2006 through 2014. Results In total, 1896 patients with biopsy-only anaplastic astrocytoma were included, among whom 363 (19.1%) received radiotherapy alone and 1533 (80.9%) received combined chemoradiotherapy. The median age at diagnosis was 60 years. Combined chemoradiotherapy was associated with a significant survival benefit when compared with radiotherapy alone on univariable analysis (median, 13.2 versus 5.6 months; hazard ratio [HR], 0.57; 95% confidence interval [CI], 0.50-0.65; p < 0.001) and on multivariable analysis (HR, 0.62; 95% CI, 0.55-0.71; p < 0.001). A significant survival benefit for combined chemoradiotherapy persisted in a propensity score-matched analysis (HR, 0.67; 95% CI, 0.56-0.78; p<0.001). Conclusions Our results suggest that combined chemoradiotherapy may be associated with significantly improved survival over radiotherapy alone in patients with anaplastic astrocytoma who undergo biopsy only.
Silicates in Ultraluminous Infrared Galaxies

We analyze the mid-infrared (MIR) spectra of ultraluminous infrared galaxies (ULIRGs) observed with the Spitzer Space Telescope’s Infrared Spectrograph. Dust emission dominates the MIR spectra of ULIRGs, and the reprocessed radiation that emerges is independent of the underlying heating spectrum. Instead, the resulting emission depends sensitively on the geometric distribution of the dust, which we diagnose with comparisons of numerical simulations of radiative transfer. Quantifying the silicate emission and absorption features that appear near 10 and 18 μm requires a reliable determination of the continuum, and we demonstrate that including a measurement of the continuum at intermediate wavelength (between the features) produces accurate results at all optical depths. With high-quality spectra, we successfully use the silicate features to constrain the dust chemistry. The observations of the ULIRGs and local sight lines require dust that has a relatively high 18 μm/10 μm absorption ratio of the silicate features (around 0.5). Specifically, the cold dust of Ossenkopf et al. is consistent with the observations, while other dust models are not. We use the silicate feature strengths to identify two families of ULIRGs, in which the dust distributions are fundamentally different. Optical spectral classifications are related to these families. In ULIRGs that harbor an active galactic nucleus, the spectrally broad lines are detected only when the nuclear surroundings are clumpy. In contrast, the sources of lower ionization optical spectra are deeply embedded in smooth distributions of optically thick dust.
Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases

The lysosome is the main catabolic hub of the cell. Owing to its role in fundamental processes such as autophagy, plasma membrane repair, mTOR signaling, and maintenance of cellular homeostasis, the lysosome has a profound influence on cellular metabolism and human health. Indeed, inefficient or impaired lysosomal function has been implicated in the pathogenesis of a number of degenerative diseases affecting various organs and tissues, most notably the brain, liver, and muscle. The discovery of the coordinated lysosomal expression and regulation (CLEAR) genetic program and its master controller, transcription factor EB (TFEB), has provided an unprecedented tool to study and manipulate lysosomal function. Most lysosome‐based processes—including macromolecule degradation, autophagy, lysosomal exocytosis, and proteostasis—are under the transcriptional control of TFEB. Interestingly, impaired TFEB signaling has been suggested to be a contributing factor in the pathogenesis of several degenerative storage diseases. Preclinical studies based on TFEB exogenous expression to reinstate TFEB activity or promote CLEAR network–based lysosomal enhancement have highlighted TFEB as a candidate therapeutic target for the treatment of various degenerative storage diseases.
Assessment of intake inadequacy and food sources of zinc of people in China

Abstract Objectives To assess the intake inadequacy and food sources of zinc of people in China. Design and subjects Diets of 68 962 subjects aged 2–101 years (urban 21 103, rural 47 859) in the 2002 China National Nutrition and Health Survey were analysed. Dietary intake was assessed using 24-hour recall for three consecutive days. Zinc intake inadequacy was calculated based on values suggested by the World Health Organization. Results The median zinc intake ranged from 4.9 mg day− 1 (urban girls, 2–3 years) to 11.9 mg day− 1 (rural males, 19+ years). The zinc density of urban residents (2–3 to 19+ years) was 5.0–5.3 mg day− 1 (1000 kcal)− 1, significantly higher than that of their rural counterparts (4.7–4.8 mg day− 1 (1000 kcal)− 1). Differences in food sources of zinc from cereal grains (27.4–45.1 vs. 51.6–63.2%) and animal foods (28.4–54.8 vs. 16.8–30.6%) were found between urban and rural residents. Zinc from vegetables and fruits (8.2–13.8 vs. 9.7–12.4%) and legumes (1.3–3.3 vs. 2.5–3.4%) was comparable between urban and rural residents. The proportion of zinc intake inadequacy ranged between 2.8% (urban females, 19+ years) and 29.4% (rural lactating women). Rural residents had higher proportions of zinc intake inadequacy than their urban counterparts. Significantly higher proportions of zinc inadequacy were found in the category of phytate/zinc molar ratio >15 for both rural and urban residents. Conclusions About 20% of rural children are at risk of inadequate zinc intake, with phytate as a potential important inhibitor. Moreover, lactating women are also considered a vulnerable group.
Neuroscience‐informed computer‐assisted cognitive training in schizophrenia

Schizophrenia is a heterogeneous psychiatric syndrome characterized by psychosis. It is also a neurodevelopmental disorder. In the earliest phases of the illness, at‐risk individuals exhibit subtle, nonspecific symptoms, including cognitive dysfunction and progressive brain volumetric loss. Generally, schizophrenia is characterized by abnormal/inefficient neural system operations and neural oscillatory activity, as well as functional disconnectivity across frontal–temporo parietal and frontal–subcortical networks; it thus may best be described as a widespread neural oscillatory connectomopathy. Despite earlier views of schizophrenia as an inevitably progressive neurodegenerative disease, emerging evidence indicates that endogenous neuroplastic capacity is retained. An active area of research is directed at understanding how best to harness this learning‐induced neuroplasticity to enhance neural system functioning, improve cognition, and prevent—and possibly even reverse—disease progression. In this review, we present an overview of results from the most widely used computer‐assisted cognitive‐training programs in schizophrenia, contrasting a broad neuropsychological rehabilitation approach with a targeted cognitive‐training approach. We then review studies on the neurobiological effects of these two training methods. Finally, we discuss future directions with a focus on the “oscillatory connectome” as a key area of investigation for developing the most precise and scientifically informed treatment approaches for this illness.
Activation of Nrf2-mediated anti-oxidant genes by antrodin C prevents hyperglycemia-induced senescence and apoptosis in human endothelial cells

In the present study, we investigated the effects of antrodin C (ADC), a maleimide derivative isolated from mycelia of Antrodia cinnamomea, on high glucose (HG, 30 mM)-accelerated endothelial dysfunction in vitro. HG-induced cytotoxicity in human umbilical vein endothelial cells (HUVECs) was significantly ameliorated by ADC. In addition, treatment with ADC significantly prevented HG-induced senescence, growth arrest at the G1-S transition phase and apoptosis in HUVECs. Moreover, the increased level of intracellular reactive oxygen species (ROS) under HG condition was significantly ameliorated by ADC. Further analysis revealed that ADC-mediated anti-oxidant effects were due to up-regulation of cellular anti-oxidant genes, such as HO-1 and NQO-1 via promotion of the transcriptional activity of Nrf2, which was further confirmed by the failure of ADC to protect HUVECs from HG-induced dysfunction under HO-1 inhibition or Nrf2 silencing. Furthermore, hyperosmotic glucose (HOG, 60 mM)-induced uncontrolled production of ROS, rapid apoptotic cell death and HUVEC injury were significantly prevented by ADC, whereas these preventive effects were barely observed in HO-1 inhibited or Nrf2 silenced cells. Taken together, these results suggest that ADC may represent a promising intervention in diabetic-associated cardiovascular diseases by activating the Nrf2-dependent cellular anti-oxidant defense system.
Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer

Purpose The purpose of this study was to assess the expression of pentose phosphate pathway- (PPP-) related proteins and their significance in clinicopathologic factors of breast cancer. Methods Immunohistochemical staining for PPP-related proteins (glucose-6-phosphate dehydrogenase [G6PDH], 6-phosphogluconolactonase [6PGL], 6-phosphogluconate dehydrogenase [6PGDH], and nuclear factor-erythroid 2-related factor 2 [NRF2]) was performed using tissue microarray (TMA) of 348 breast cancers. mRNA levels of these markers in publicly available data from the Cancer Genome Atlas project and Kaplan-Meier plotters were analyzed. Results Expression of G6PDH and 6PGL was higher in HER-2 type (p < 0.001 and p = 0.009, resp.) and lower in luminal A type. 6PGDH expression was detected only in TNBC subtype (p < 0.001). G6PDH positivity was associated with ER negativity (p = 0.001), PR negativity (p = 0.001), and HER-2 positivity (p < 0.001), whereas 6PGL positivity was associated with higher T stage (p = 0.004). The 562 expression profile from the TCGA database revealed increased expression of G6PDH and 6PG in the tumor compared with normal adjacent breast tissue. The expression of G6PDH was highest in HER-2 type. HER-2 and basal-like subtypes showed higher expression of 6PGDH than luminal types. Conclusion PPP-related proteins are differentially expressed in breast cancer according to molecular subtype, and higher expression of G6PDH and 6PGL was noted in HER-2 subtype.
A Survey of Real-Time Strategy Game AI Research and Competition in StarCraft

This paper presents an overview of the existing work on AI for real-time strategy (RTS) games. Specifically, we focus on the work around the game StarCraft, which has emerged in the past few years as the unified test bed for this research. We describe the specific AI challenges posed by RTS games, and overview the solutions that have been explored to address them. Additionally, we also present a summary of the results of the recent StarCraft AI competitions, describing the architectures used by the participants. Finally, we conclude with a discussion emphasizing which problems in the context of RTS game AI have been solved, and which remain open.
The computational content of classical arithmetic

Almost from the inception of Hilbert's program, foundational and structural efforts in proof theory have been directed towards the goal of clarifying the computational content of modern mathematical methods. This essay surveys various methods of extracting computational information from proofs in classical first-order arithmetic, and reflects on some of the relationships between them. Variants of the G\"odel-Gentzen double-negation translation, some not so well known, serve to provide canonical and efficient computational interpretations of that theory.
Ichnotaxonomic Review of Large Ornithopod Dinosaur Tracks: Temporal and Geographic Implications

Background Large ornithopod tracks are known from the Upper Jurassic to the uppermost Cretaceous rocks of all continents but Antarctica. They include the tracks historically called Iguanodon footprints, iguanodontid footprints, hadrosaur/hadrosaurid footprints, and other large ornithopod tracks that have been used to define ichnotaxa. More than 40 ichnospecies based on large ornithopod tracks have been defined, but the validity of many of them is questionable. Methodology/Principal Findings 34 ichnogenera and 44 ichnospecies have been analysed in this work. Many of them are considered to be invalid because they have been defined on the basis of poorly preserved tracks without diagnostic features, have an inadequate diagnosis, or are based on temporal and/or geographical criteria. Only eight ichnospecies belonging to the ichnogenera Caririchnium, Iguanodontipus and Hadrosauropodus are here regarded as valid. Conclusions/Significance The monospecific ichnogenus Iguanodontipus (I. burreyi) is characterized by a small, rounded heel and elongate, narrow digit impressions. Its distribution is limited to the Berriasian-Valanginian of Europe. Caririchnium consists of four ichnospecies (C. magnificum [type ichnospecies], C. kortmeyeri, C. billsarjeanti and C. lotus) with a large, rounded heel and short, wide digit impressions. This ichnogenus ranges from the Berriasian-Hauterivian to the Aptian-Albian of South America, North America, Asia and Europe. Finally, Hadrosauropodus (three ichnospecies: H. langstoni [type ichnospecies], H. leonardii and H. kyoungsookimi) shows a large, bilobed heel and short, wide digit impressions. It is known from the Aptian-Albian to the Maastrichtian of North America, Asia and Europe. The ichnofamily Iguanodontipodidae includes large iguanodontian tracks characterized mainly by mesaxonic, tridactyl and subsymmetrical pes tracks that are as wide as (or wider than) long and have one pad impression in each digit and one in the heel. Its distribution is confidently limited to the Cretaceous of Europe, Asia, North America and South America.
Drought‐induced nitrous oxide flux dynamics in an enclosed tropical forest

El Niño–La Niña cycles strongly influence dry and wet seasons in the tropics and consequently nitrous oxide (N2O) emissions from tropical rainforest soils. We monitored whole‐system and soil chamber N2O fluxes during 5‐month‐long droughts in the Biosphere 2 tropical forest to determine how rainfall changes N2O production. A consistent pattern of N2O flux changes during drought and subsequent wetting emerged from our experiments. Soil surface drying during the first days of drought, presumably increased gas transport out of the soil, which increased N2O fluxes. Subsequent drying caused an exponential decrease in whole‐system (4.0±0.1% day−1) and soil chamber N2O flux (8.9±0.8% day−1; south chamber; and 13.7±1.1% day−1; north chamber), which was highly correlated with soil moisture content. Soil air N2O concentration ([N2O]) and flux measurements revealed that surface N2O production persisted during drought. The first rainfall after drought triggered a N2O pulse, which amounted to 25% of drought‐associated reduction in N2O flux and 1.3±0.4% of annual N2O emissions. Physical displacement of soil air by water and soil chemistry changes during drought could not account for the observed N2O pulse. We contend that osmotic stress on the microbial biomass must have supplied the N source for pulse N2O, which was produced at the litter–soil interface. After the pulse, N2O fluxes were consistently 90% of predrought values. Nitrate change rate, nutrient, [N2O], and flux analyses suggested that nitrifiers dominated N2O production during the pulse and denitrifiers during wet conditions. N2O flux measurements in Biosphere 2, especially during the N2O pulse, demonstrate that large‐scale integration methods, such as flux towers, are essential for improving ecosystem N2O flux estimates.
Bursicon-α subunit modulates dLGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-β

ABSTRACT Bursicon is the main regulator of post molting and post eclosion processes during arthropod development. The active Bursicon hormone is a heterodimer of Burs-α and Burs-β. However, adult midguts express Burs-α to regulate the intestinal stem cell niche. Here, we examined the potential expression and function of its heterodimeric partner, Burs-β in the adult midgut. Unexpectedly, our evidence suggests that Burs-β is not significantly expressed in the adult midgut. burs-β mutants displayed the characteristic developmental defects but showed wild type-like adult midguts, thus uncoupling the developmental and adult phenotypes seen in burs-α mutants. Gain of function data and ex vivo experiments using a cAMP biosensor, demonstrated that Burs-α is sufficient to drive stem cell quiescence and to activate dLGR2 in the adult midgut. Our evidence suggests that the post developmental transactivation of dLGR2 in the adult midgut is mediated by Burs-α and that the β subunit of Bursicon is dispensable for these activities.
Two Degree-of-Freedom Robust Digital Controller Design With Bouc-Wen Hysteresis Compensator for Piezoelectric Positioning Stage

The compensation of nonlinear hysteretic behavior is one of the mandatory requirements in order to achieve precise reference tracking performance from a piezoelectric positioning stage. A common practice of employing an inverse hysteresis model as a feed-forward compensator must deal with modeling complexity; consequently, real-time tracking performance suffers due to modeling errors. In this paper, a two degree-of-freedom robust digital feedback controller design scheme in the presence of a simple Bouc-Wen hysteresis feed-forward compensator is proposed to deal with the dual challenge of modeling complexity and modeling errors. The proposed control scheme takes into account the performance and robustness requirements simultaneously. The desired performance and robustness requirements are expressed by means of constraints on the shapes of closed-loop sensitivity functions (CLSFs). Then, pole placement with sensitivity function shaping methodology is adopted so that the CLSFs respect their respective constraints and the desired performance with robustness could be achieved. The presented experimental results verify the effectiveness of the proposed control scheme in achieving the peak-to-peak reference tracking error of 0.36% for the desired displacement of $12~\mu \text{m}$ with tracking frequency of 10 Hz, whereas the peak-to-peak tracking error of 4.33% is observed with a Bouc-Wen hysteresis feed-forward compensator (without the feedback controller). Overall, 91% improvement is achieved in reducing the reference tracking error with the proposed control scheme.
Transport of volatile solutes through AQP1

For almost a century it was generally assumed that the lipid phases of all biological membranes are freely permeable to gases. However, recent observations challenge this dogma. The apical membranes of epithelial cells exposed to hostile environments, such as gastric glands, have no demonstrable permeability to the gases CO2 and NH3. Additionally, the water channel protein aquaporin 1 (AQP1), expressed at high levels in erythrocytes, can increase membrane CO2 permeability when expressed in Xenopus oocytes. Similarly, nodulin‐26, which is closely related to AQP1, can act as a conduit for NH3. A key question is whether aquaporins, which are abundant in virtually every tissue that transports O2 and CO2 at high levels, ever play a physiologically significant role in the transport of small volatile molecules. Preliminary data are consistent with the hypothesis that AQP1 enhances the reabsorption of HCO3− by the renal proximal tubule by increasing the CO2 permeability of the apical membrane. Other preliminary data on Xenopus oocytes heterologously expressing the electrogenic Na+‐HCO3− cotransporter (NBC), AQP1 and carbonic anhydrases are consistent with the hypothesis that the macroscopic cotransport of Na+ plus two HCO3− occurs as NBC transports Na+ plus CO32‐ and AQP1 transports CO2 and H2O. Although data ‐ obtained on AQP1 reconstituted into liposomes or on materials from AQP1 knockout mice ‐ appear inconsistent with the model that AQP1 mediates substantial CO2 transport in certain preparations, the existence of unstirred layers or perfusion‐limited conditions may have masked the contribution of AQP1 to CO2 permeability.