Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of an Intravenous Lipid Challenge and Free Fatty Acid Elevation on In Vivo Insulin Sensitivity in African American Versus Caucasian Adolescents

OBJECTIVE—African American youth have lower insulin sensitivity than their Caucasian peers, but the metabolic pathways responsible for this difference remain unknown. Free fatty acids (FFAs) are associated with insulin resistance through the Randle cycle. The present investigation determined whether elevating FFA is more deleterious to insulin sensitivity in African American than in Caucasian adolescents. RESEARCH DESIGN AND METHODS—Insulin sensitivity (3-h hyperinsulinemic-euglycemic clamp) was evaluated in 22 African American and 21 Caucasian adolescents on two occasions: 1) infusion of normal saline and 2) infusion of 20% intralipid. RESULTS—During intralipid infusion, fasting insulin and C-peptide concentrations increased while fasting glucose and basal glucose turnover did not change in either group. Insulin sensitivity decreased similarly in African American (normal saline 7.65 ± 0.61 vs. intralipid 5.15 ± 0.52 μmol · kg−1 · min−1 per pmol/l) and Caucasian subjects (normal saline 8.97 ± 0.85 vs. intralipid 5.96 ± 0.56 μmol · kg−1 · min−1 per pmol/l) (P < 0.001). CONCLUSIONS—African American and Caucasian adolescents respond to FFA elevation similarly through increased fasting insulin secretion to maintain fasting glucose homeostasis and reduced peripheral glucose uptake and insulin resistance. Thus, African American adolescents are not more susceptible to FFA-induced insulin resistance than Caucasian youth.
Antidiabetic and Antioxidant Impacts of Desert Date (Balanites aegyptiaca) and Parsley (Petroselinum sativum) Aqueous Extracts: Lessons from Experimental Rats

Medicinal plants are effective in controlling plasma glucose level with minimal side effects and are commonly used in developing countries as an alternative therapy for the treatment of type 1 diabetes mellitus. The aim of this study is to evaluate the potential antidiabetic and antioxidant impacts of Balanites aegyptiaca and Petroselinum sativum extracts on streptozotocin-induced diabetic and normal rats. The influences of these extracts on body weight, plasma glucose, insulin, total antioxidant capacity (TAC), malondialdehyde (MDA) levels, and liver-pyruvate kinase (L-PK) levels were assessed. Furthermore, the weight and histomorphological changes of the pancreas were studied in the different experimental groups. The herbal preparations significantly reduced the mean plasma glucose and MDA levels and significantly increased the mean plasma insulin, L-PK, and TAC levels in the treated diabetic groups compared to the diabetic control group. An obvious increase in the weight of the pancreas and the size of the islets of Langerhans and improvement in the histoarchitecture were evident in the treated groups compared to untreated ones. In conclusion, the present study provides a scientific evidence for the traditional use of these extracts as antidiabetic and antioxidant agents in type 1 diabetes mellitus.
An analysis of the redistributive effects of agricultural policy in Tuscany with comparative results for Scotland

The paper provides an empirical study of the redistributive effects of agricultural policy in Tuscany which finds that the provision of support increased absolute income inequality within the agricultural community because the distribution of transfers was both vertically and horizontally inequitable. These conclusions are shown to hold whether or not non-farm incomes are taken into account and for a range of alternative definitions of the agricultural community. The results for Scotland are broadly comparable except that the distribution of transfers was progressive not regressive, reflecting differences between the two regions in the degree of dependency of agriculture on support.
Job Destruction, Job Creation and Unemployment in Transition Countries: What Can We Learn?

Sixteen years into the transition, the problem of high joblessness has not been solved. Of the three explanations commonly discussed (i.e. ongoing reallocation; finished reallocation with redundant labour; wrong choice of institutional framework), we concentrated on the ongoing reallocation hypothesis. We show that there is a negative correlation between job creation in the private sector and unemployment. We also show that long-term unemployment depends on current and past values of short-term unemployment and that this path-dependence fades away as soon as we reach time t-3. We interpret this result as an indication that the process of reallocation started at the beginning of the 1990s still influences today’s labour market. We address three components of the transition debate: shock therapy versus gradualism; privatization; and political change. Contrary to Godoy and Stiglitz (2006), we do not find gradualism superior to shock therapy in terms of private sector growth. In addition, we confirm that full privatization is positively associated with job destruction in the state sector. Finally, we show that during early years of democratization the state sector was dismantled more vigorously than in other periods.
On the effect of quantization on performance at high rates

We study the effect of quantization on the performance of a scalar dynamical system in the high rate regime. We evaluate the LQ cost for two commonly used quantizers: uniform and logarithmic and provide a lower bound on performance of any centroid-based quantizer based on entropy arguments. We also consider the case when the channel drops data packets stochastically
Seeing is believing: Neural mechanisms of action–perception are biased by team membership

Group identification can lead to a biased view of the world in favor of “in‐group” members. Studying the brain processes that underlie such in‐group biases is important for a wider understanding of the potential influence of social factors on basic perceptual processes. In this study, we used functional magnetic resonance imaging (fMRI) to investigate how people perceive the actions of in‐group and out‐group members, and how their biased view in favor of own team members manifests itself in the brain. We divided participants into two teams and had them judge the relative speeds of hand actions performed by an in‐group and an out‐group member in a competitive situation. Participants judged hand actions performed by in‐group members as being faster than those of out‐group members, even when the two actions were performed at physically identical speeds. In an additional fMRI experiment, we showed that, contrary to common belief, such skewed impressions arise from a subtle bias in perception and associated brain activity rather than decision‐making processes, and that this bias develops rapidly and involuntarily as a consequence of group affiliation. Our findings suggest that the neural mechanisms that underlie human perception are shaped by social context. Hum Brain Mapp 34:2055–2068, 2013. © 2012 Wiley Periodicals, Inc.
Genetic Programming + Unfolding Embryology in Automated Layout Planning

Automated layout planning aims to the implementation of computational methods for the generation and the optimization of floor plans, considering the spatial configuration and the assignment of activities. Sophisticated strategies such as Genetic Algorithms have been implemented as heuristics of good solutions. However, the generative forces that derive from the social structures have been often neglected. This research aims to illustrate that the data that encode the layout’s social and cultural generative forces, can be implemented within an evolutionary system for the design of residential layouts. For that purpose a co-operative system was created, which is composed of a Genetic Programming algorithm and an agent-based unfolding embryology procedure that assigns activities to the spaces generated by the GP algorithm. The assignment of activities is a recursive process which follows instructions encoded as permeability graphs. Furthermore, the Ranking Sum Fitness evaluation method is proposed and applied for the achievement of multi-objective optimization. Its efficiency is tested against the Weighted-Sum Fitness function. The system’s results, both numerical and spatial, are compared to the results of a conventional evolutionary approach. This comparison showed that, in general, the proposed system can yield better solutions.
On the Global Convergence of Majorization Minimization Algorithms for Nonconvex Optimization Problems

In this paper, we study the global convergence of majorization minimization (MM) algorithms for solving nonconvex regularized optimization problems. MM algorithms have received great attention in machine learning. However, when applied to nonconvex optimization problems, the convergence of MM algorithms is a challenging issue. We introduce theory of the Kurdyka- Lojasiewicz inequality to address this issue. In particular, we show that many nonconvex problems enjoy the Kurdyka- Lojasiewicz property and establish the global convergence result of the corresponding MM procedure. We also extend our result to a well known method that called CCCP (concave-convex procedure).
The SIGMORPHON 2016 Shared Task—Morphological Reinflection

The 2016 SIGMORPHON Shared Task was devoted to the problem of morphological reinﬂection. It introduced morphological datasets for 10 languages with diverse ty-pological characteristics. The shared task drew submissions from 9 teams representing 11 institutions reﬂecting a variety of approaches to addressing supervised learning of reinﬂection. For the simplest task, in-ﬂection generation from lemmas, the best system averaged 95.56% exact-match accuracy across all languages, ranging from Maltese (88.99%) to Hungarian (99.30%). With the relatively large training datasets provided, recurrent neural network architectures consistently performed best—in fact, there was a signiﬁcant margin between neural and non-neural approaches. The best neural approach, averaged over all tasks and languages, outperformed the best non-neural one by 13.76% absolute; on individual tasks and languages the gap in accuracy sometimes exceeded 60%. Overall, the results show a strong state of the art, and serve as encouragement for future shared tasks that explore morphological analysis and generation with varying degrees of supervision.
Detection of a high frequency break in the X-ray power spectrum of Ark 564

We present a power spectrum analysis of the long ASCA observation of Ark 564 in June/July 2001. The observed power spectrum covers a frequency range of ∼3.5 decades. We detect a high frequency break at ∼2 x 10 - 3 Hz. Thepower spectrum has an rms of ∼30% and a slope of ∼-1 and ∼-2 below and above the break frequency. When combined with the results from a long RXTE observation (Pounds et al. 2001), the observed power spectra of Ark 564 and Cyg X-1 (in the low/hard state) are almost identical, showing a similar shape and rms amplitude. However, the ratio of the high frequency breaks is very small (∼10 3 - 4 ), implying that these characteristic frequencies are not indicative of the black hole mass. This result supports the idea of a small black hole mass/high accretion rate in Ark 564.
Performance Analysis of Two-Way Amplify-and-Forward Relaying in the Presence of Co-Channel Interferences

The performance of two-way amplify-and-forward (AF) relaying networks, considering transmissions over independent but not necessarily identically distributed Rayleigh fading channels in the presence of a finite number of co-channel interferers, is studied. Specifically, closed-form expressions for the cumulative distribution function (CDF) of the equivalent signal-to-interference-plus-noise ratio (SINR), the error probability, the outage probability and the system's achievable rate, are presented. Furthermore, an asymptotic expression for the probability density function (PDF) of the equivalent instantaneous SINR is derived, based on which simple and general asymptotic formulas for the error and outage probabilities are derived and analyzed. Numerical results are also provided, sustained by simulations which corroborate the exactness of the theoretical analysis.
Involvement of the Kynurenine Pathway in Human Glioma Pathophysiology

The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and picolinic acid (PIC), the excitotoxin, quinolinic acid (QUIN) and the essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD+). The enzymes indoleamine 2,3-dioxygenase-1 (IDO-1), indoleamine 2,3-dioxygenase-2 (IDO-2) and tryptophan 2,3-dioxygenase (TDO-2) initiate the first step of the KP. IDO-1 and TDO-2 induction in tumors are crucial mechanisms implicated to play pivotal roles in suppressing anti-tumor immunity. Here, we report the first comprehensive characterisation of the KP in 1) cultured human glioma cells and 2) plasma from patients with glioblastoma (GBM). Our data revealed that interferon-gamma (IFN-γ) stimulation significantly potentiated the expression of the KP enzymes, IDO-1 IDO-2, kynureninase (KYNU), kynurenine hydroxylase (KMO) and significantly down-regulated 2-amino-3-carboxymuconate semialdehyde decarboxylase (ACMSD) and kynurenine aminotransferase-I (KAT-I) expression in cultured human glioma cells. This significantly increased KP activity but significantly lowered the KYNA/KYN neuroprotective ratio in human cultured glioma cells. KP activation (KYN/TRP) was significantly higher, whereas the concentrations of the neuroreactive KP metabolites TRP, KYNA, QUIN and PIC and the KYNA/KYN ratio were significantly lower in GBM patient plasma (n = 18) compared to controls. These results provide further evidence for the involvement of the KP in glioma pathophysiology and highlight a potential role of KP products as novel and highly attractive therapeutic targets to evaluate for the treatment of brain tumors, aimed at restoring anti-tumor immunity and reducing the capacity for malignant cells to produce NAD+, which is necessary for energy production and DNA repair.
Antimicrobial Effect of Malpighia Punicifolia and Extension of Water Buffalo Steak Shelf‐Life

Abstract In the present study, a multiple approach was used to characterize Malpighia punicifolia extract and to evaluate its inhibitory activity against several meat spoilage bacteria. First, volatile fraction, vitamins and phenolic compounds of the extract obtained by supercritical fluid extraction were determined by GC‐MS and HPLC. Then, the antimicrobial action of the extract was in vitro evaluated against Pseudomonas putida DSMZ 291T, Pseudomonas fluorescens DSMZ 50009T, Pseudomonas fragi DSMZ 3456T, and Brochothrix thermosphacta DSMZ 20171T by the agar well diffusion assay and by the agar dilution test. Based on the results of the minimum inhibitory concentration (MIC) against the assayed bacteria, 4 different concentrations of the extract were used in a challenge test on water buffalo steaks stored for 21 d at 4 °C. Results of chemical analyses showed that M. punicifolia extract is characterized by the presence of several compounds, already described for their antimicrobial (phenolic acids, flavonones, and furanes) and antioxidant (ascorbic acid) properties. The in vitro detection of antimicrobial activities highlighted that the extract, used at 8% concentration, was able to inhibit all the target bacteria. Moreover, very low MIC values (up to 0.025%) were detected. In situ tests, performed on water buffalo steaks treated with the extract in the concentration range 0.025% to 0.05%, showed a strong inhibition of both intentionally inoculated bacteria and naturally occurring microorganisms. Positive results, in terms of color and odor, were also observed during the entire storage of steaks preserved with the extract.
A Lysozyme Concentration, pH, and Time-Dependent Isothermal Transformation Diagram Reveals Fibrous Amyloid and Non-Fibrous, Amorphous Aggregate Species

Deposition of aggregated protein is associated with many human diseases. The mechanism by which protein aggregate species cause cellular death remains unclear. A profile revealing protein aggregation products under a diverse set of conditions allows the search of novel aggregate products and potential pathogens. To achieve this end, an isothermal transformation diagram (ITD) of lysozyme aggregation was constructed. AFM, TEM, and Thioflavin T binding assays were used to analyze the aggregate species synthesized under a broad range of pH values, protein concentrations, and incubation times. Four states were found: 1) soluble protein species; 2) insoluble amyloid fibers; 3) insoluble amorphous aggregates; and 4) protein hydrogels. The hydrogel-a rises from aggregated amyloid fibers. This work is part of an effort to construct an array of ITDs reporting aggregation properties of many disease relevant proteins, including amyloid beta, tau, α-synuclein, and others involved in protein aggregation diseases. In addition, we propose hydrogel cyto toxicity as a potential novel mechanism in the pathogenesis of amyloid diseases.
Idiotypic cross-reactivity between antibodies of different specificities

Cross-idiotypic specificity has been demonstrated between antibody populations of different specificities using antibodies directed toward human sickle cell hemoglobin (HbS). A site-specific antibody directed toward the beta6-position of HbS, anti-Val, was used to elicit an anti- idiotypic response in rabbits. Using this anti-idiotypic serum, idiotypic cross-reactivity was demonstrated between antibody populations that bind to human adult hemoglobin (HbA). It was demonstrated that in the case of the goat antibodies, these idiotypically cross-reacting antibodies are directed towards the beta6- position of the hemoglobin molecule. However, they differ in their specificity, binding to this site on HbA, whereas anti-Val binds only to HbS. The sheep antibody populations directed toward HbS differ qualitatively from those of the goat. Using rabbit anti-idiotypic serum specific for sheep anti-Val, cross-reactivity could be demonstrated with antibodies directed toward the alpha-chain of the hemoglobin molecule, as well as the beta-chain. There was also a low level of cross-reactivity with antibodies from a goat immunized with HbA.
Approaches taken by Australian universities to documenting institutional e-learning strategies

The way in which a university communicates a strategy that it is attempting to implement to its staff can have an important bearing on the effectiveness of the strategy. However, there are currently no generally accepted conventions governing the scope, structure, content and language of strategy documents. E-learning is an area of activity in which most universities are currently striving achieve major change and therefore the documents being used to communicate institutional strategies in relation to e-learning merit investigation. A study was undertaken of the ways in which Australian universities are documenting their strategies in relation to e-learning and the types of activities that are being identified in strategy documents. The study found that two distinct approaches to documenting institutional e-learning strategies are being adopted. Some universities are developing discrete strategies whereas other universities are embedding their strategies in more general documents. The most common themes that were identified in discrete e-learning strategies included: learning management system(s), networking and infrastructure, planning, policy and strategy development, evaluation, support for projects related to e-learning, development of courses, teaching and support, learning spaces, and future developments. The themes that more than one university covered in general documents included: staff development, programs, use, improved access, effectiveness, and teaching/learning spaces. Comparison of the documents provided by institutions showed that when e-learning strategies have been embedded in more general documents the range of aspects of elearning that are covered tends to be less wide-ranging than is the case when discrete strategies have been produced.
Sequential investments and options to own

Contingent ownership structures are prevalent in joint ventures. We offer an explanation based on the investment incentives provided by such an arrangement. We consider a holdup problem in which two parties make relationship-specific investments sequentially to generate a joint surplus in the future. In our model, the following ownership structure implements first-best investments: one party owns the firm initially, while the other party has the option to buy the firm at a set price at a later date. This result is robust to the possibility of renegotiation and uncertainty.
Education and Saving: The Long-Term Effects of High School Financial Curriculum Mandates

Over the last forty years, the majority of states have adopted consumer education policies, and a sizable minority have specifically mandated that high school students receive instruction on topics related to household financial decision-making (budgeting so forth). In this paper, we attempt to determine whether the curricula arising from these mandates have had any discernable effect on adult decisions regarding saving. Using a unique household survey, we exploit the variation in requirements both across states and over time to identify the effects of interest. The evidence indicates that mandates have significantly raised both exposure to financial curricula and subsequent asset accumulation once exposed students reached adulthood. These effects appear to have been gradual rather than immediate -- a probable reflection of implementation lags.
Neural mechanisms involved in the processing of global and local aspects of hierarchically organized visual stimuli.

We investigated the functional anatomy involved in sustaining or switching visual attention between different perceptual levels, using functional imaging measures of neural activity. Two experiments were carried out using hierarchically organized letters (i.e. large letters made out of small letters). In a divided-attention task, subjects were required to switch attention between local and global levels. The number of successive stimuli for which subjects had to sustain attention to either the global or local level co-varied significantly with temporal-parietal activations bilaterally. Other activations were also observed in the right orbitofrontal cortex, the right dorsolateral prefrontal cortex, and the right middle temporal gyrus. The number of switches between levels co-varied significantly with activations in the left supplementary motor area and the left medial parietal cortex. In the directed-attention task, subjects were required to attend to either the global or local level of the stimuli throughout all trials; attention to the global aspect resulted in significant activation of the right lingual gyrus while attention to the local aspect significantly activated the left inferior occipital cortex. We suggest that left hemisphere activations with increasing numbers of switches between perceptual levels reflect increased demands on an executive attentional system, while sustained attention to either level activates a predominantly right hemispheric network involving temporal-parietal and dorsolateral prefrontal regions. Overall, the results provide evidence for relative hemispheric specialization for global and local processing in accordance with previous neuropsychological studies. In addition, the findings demonstrate that early visual processing mechanisms in the prestriate cortex are influenced by an attentional system in temporal-parietal areas.