Miracle-dz/UniFAR-FTUs huggingface dataset:
Perirhinal and parahippocampal cortices of the macaque monkey: Cytoarchitectonic and chemoarchitectonic organization

Findings from recent tract‐tracing studies examining the cortical and subcortical connectivity of the medial temporal lobe showed that the pattern of connections of areas TH and TF of the parahippocampal cortex were consistent with previous boundary demarcations of this region. In contrast, the connections of the perirhinal cortex (areas 35 and 36) indicated that the border of area 36 should be placed several millimeters more lateral than in earlier descriptions in the literature. The connections of this region also suggested that the perirhinal cortex extends rostrodorsally to include the medial portion of what is typically referred to as the temporal pole (areas TG, 38, or Pro). To determine if cyto‐ and chemoarchitectonic characteristics are consistent with the boundary scheme suggested by our tract‐tracing studies, we carried out a detailed analysis of Nissl‐ and SMI‐32‐stained material throughout the perirhinal and parahippocampal cortices of the macaque monkey. The staining patterns seen in both these preparations are in excellent agreement with the boundaries defined by earlier connectional studies. Based on these studies, we recognize areas 35 and area 36 of the perirhinal cortex and area 36 contains five subdivisions. The parahippocampal cortex is composed of areas TH and TF and area TF contains two subdivisions. For both the perirhinal and parahippocampal cortices, we provide descriptions of the cytoarchitectonic and chemoarchitectonic features that are most useful for defining each cortical subdivision, as well as the features most useful for defining the boundaries with adjacent cortical regions. We discuss these findings in the context of the results of previous tract‐tracing studies. J. Comp. Neurol. 463:67–91, 2003. © 2003 Wiley‐Liss, Inc.
Automated Usability Tests for Mobile Devices through Live Emotions Logging

Usability tests for mobile phones software present several consistent obstacles. The issue of observing users' interaction within a controlled and supervised environment versus unsupervised field tests is a significant one. Additionally, the burden of frequently time-consuming and expensive usability tests for small software development teams are evident. This work proposes the use of a system to implement emotions logging in automated usability tests for mobile phones. We do this by efficiently, easily and cost-effectively assessing the users' affective state by evaluating their expressive reactions during a mobile software usability evaluation process. These reactions are collected using the front camera on mobile devices.
Scheduling for VoIP service in cdma2000 1x EV-DO

Recently cdma2000 1x EV-DO (HDR) system has begun to be deployed in some countries to support high data rate services in cellular networks. The system is originally designed to support data services, but now is expected to serve some real-time traffic including VoIP. For VoIP service with delay hound and low loss requirements, we propose a frame structure considering delay bound and a scheduling algorithm reflecting channel conditions. To schedule VoIP, we adopt the maximal rate algorithm and the proportionally fair algorithm. The proportionally fair algorithm (PF) was known to be appropriate for elastic-traffic, however, from simulation results, we conclude that the PF algorithm with the channel test is an appropriate scheduling scheme to provide QoS of VoIP. When the required slot portion of VoIP is 75%, the loss rate is about 1% on the average and 3% in the worse case. On the other hand, the maximal rate algorithm shows twice of the loss rate for the same delay bound and load. Additionally we propose a simple admission control scheme for VoIP service that controls the average portion of slots occupied by VoIP packets.
Switched Ethernet for factory communication

Focuses on the special requirements of the control-level within factory communication systems to transmit real-time data via a switched Ethernet network. A performance evaluation of switched Ethernet is presented by providing simulation results. The simulations study the influence of different network topologies as well as the scheduling algorithms first-come-first-served and priority queuing within devices and intermediate systems, like switches. Furthermore we suggest a bus-like topology to enable fieldbus-like cabling qualities. Moreover the paper considers the impact of the dwell time within the stations upon real-time behavior.
Predicting Future Anabolic-Androgenic Steroid Use Intentions With Current Substance Use: Findings From an Internet-Based Survey

Objective:To explore how current substance use, including the use of sports supplements and illicit drugs, may impact upon a person's future intentions to use anabolic-androgenic steroids (AAS). Design:Web-based survey. Participants:Two hundred fourteen exercising males (mean age, 30 years; range, 17-61 years) recruited from 5 gymnasia in Sydney, Australia, completed a web-based survey. The survey contained questions relating to sport supplement use, illicit substance use, reasons for currently not using AAS, and reasons for intending to use AAS in the future. Interventions:Participants completed a structured interview schedule that included questions regarding licit and illicit substance use, reasons for non-AAS use, and, where appropriate, reasons for intended future AAS use. Main Outcome Measures:The planned main outcome measure was positive intention to use AAS. Results:Sixteen percent of the sample indicated that they would use AAS in the future. Reasons for future AAS use included increasing muscle size (80%), improving appearance (74%), and increasing strength (57%). Four-fifths (80%) of the sample reported use of sports supplements, with vitamins and protein supplements commonly reported (83% and 67%, respectively); more than one-third (36%) reported use of creatine in the past 6 months. Half (52%) of the sample reported use of illicit substances in the preceding 6 months, with amphetamines and cannabis commonly reported (66% and 62%, respectively). Significant predictors of intending to use AAS included past 6-month use of creatine and knowing AAS users. Conclusions:The use of sport supplements and/or illicit substances may remove barriers for the future use of such drugs as AAS. Future research is necessary to explore in depth whether such substances may act as a “gateway” to future AAS use.
Atmospheric chemistry and physics in the atmosphere of a developed megacity (London): An overview of the REPARTEE experiment and its conclusions

The REgentsPARk and Tower Environmental Experiment (REPARTEE) comprised two campaigns in London in October 2006 and October/November 2007. The experiment design involved measurements at a heavily trafficked roadside site, two urban background sites and an elevated site at 160–190 m above ground on the BT Tower, supplemented in the second campaign by Doppler lidar measurements of atmospheric vertical structure. A wide range of measurements of airborne particle physical metrics and chemical composition were made as well as measurements of a considerable range of gas phase species and the fluxes of both particulate and gas phase substances. Significant findings include (a) demonstration of the evaporation of trafficgenerated nanoparticles during both horizontal and vertical atmospheric transport; (b) generation of a large base of information on the fluxes of nanoparticles, accumulation mode Published by Copernicus Publications on behalf of the European Geosciences Union. 3066 R. M. Harrison et al.: Atmospheric chemistry and physics in the atmosphere of London particles and specific chemical components of the aerosol and a range of gas phase species, as well as the elucidation of key processes and comparison with emissions inventories; (c) quantification of vertical gradients in selected aerosol and trace gas species which has demonstrated the important role of regional transport in influencing concentrations of sulphate, nitrate and secondary organic compounds within the atmosphere of London; (d) generation of new data on the atmospheric structure and turbulence above London, including the estimation of mixed layer depths; (e) provision of new data on trace gas dispersion in the urban atmosphere through the release of purposeful tracers; (f) the determination of spatial differences in aerosol particle size distributions and their interpretation in terms of sources and physicochemical transformations; (g) studies of the nocturnal oxidation of nitrogen oxides and of the diurnal behaviour of nitrate aerosol in the urban atmosphere, and (h) new information on the chemical composition and source apportionment of particulate matter size fractions in the atmosphere of London derived both from bulk chemical analysis and aerosol mass spectrometry with two instrument types.
EGF signalling pathway regulates colon cancer stem cell proliferation and apoptosis

Cancer stem cells (CSCs) compose a subpopulation of cells within a tumour that can self‐renew and proliferate. Growth factors such as epidermal growth factor (EGF) and basic fibroblast growth factor (b‐FGF) promote cancer stem cell proliferation in many solid tumours. This study assesses whether EGF, bFGF and IGF signalling pathways are essential for colon CSC proliferation and self‐renewal.
Behavioural phenotypes associated with specific genetic disorders: evidence from a population-based study of people with Prader-Willi syndrome

Background. Prader-Willi syndrome (PWS) is a genetic disorder resulting in obesity, short stature, cryptorchidism, learning disabilities (mental retardation) and severe neonatal hypotonia. Associated with the syndrome are a number of behaviours that are sufficiently distinctive that the syndrome is considered to have a specific ‘behavioural phenotype’. Methods. Through multiple sources we attempted to identify all people with PWS living in one region in the UK. This cohort was augmented by people with PWS from other regions, and a contrast group of people with learning disabilities of varied aetiologies. The main carers were interviewed, using structured and semi-structured interview schedules, to establish the presence and severity of specific behaviours, and PWS diagnostic criteria. The intellectual functioning and attainments of all were determined. Blood samples were obtained for genetic diagnosis from all consenting participants. Results. Although excessive eating was recognized as a potentially severe problem in those with PWS, it was almost universally controlled by food restriction, and therefore not seen as a ‘problem behaviour’. Those with PWS differed from a learning disabled group of other aetiologies in the prevalence rates of skin picking, temper tantrums, compulsive behaviours and mood fluctuations, and also in the profile of their adaptive behaviours. Conclusions. The study confirms the distinct behavioural phenotype of PWS. Specific behaviours occurred significantly more frequently in PWS, compared with an age and BMI matched learning disabled comparison group. A factor analysis of the behaviours involved resulted in three factors that we hypothesized to be independent, and to arise from different mechanisms.
Metabolic theory explains latitudinal variation in common carp populations and predicts responses to climate change

Climate change is expected to alter temperature regimes experienced by fishes, which may also alter life history traits. However, predicting population-level responses to climate change has been difficult. Metabolic theory of ecology has been developed to explain how metabolism controls a variety of ecological processes, including life history attributes. Thus, this theory may be a useful tool for predicting fish population responses to climate change. To understand how climate change may alter freshwater fish life history, we measured population characteristics (e.g., recruitment, growth, body size, and mortality) of 21 North American common carp Cyprinus carpio populations spanning a latitudinal gradient of >2,700 km. We then evaluated (1) how metabolic rates vary with body size and temperature (i.e., metabolic theory of ecology) to interpret latitudinal patterns in life history traits and (2) how predicted increases in annual temperature as a result of climate change may alter metabolism and population.
A New Unblocking Technique to Warmstart Interior Point Methods Based on Sensitivity Analysis

One of the main drawbacks associated with Interior Point Methods (IPMs) is the perceived lack of an efficient warmstarting scheme which would enable the use of information from a previous solution of a similar problem. Recently there has been renewed interest in the subject. A common problem with warmstarting for IPM is that an advanced starting point which is close to the boundary of the feasible region, as is typical, might lead to blocking of the search direction. Several techniques have been proposed to address this issue. Most of these aim to lead the iterate back into the interior of the feasible region—we classify them as either “modification steps” or “unblocking steps” depending on whether the modification is taking place before solving the modified problem to prevent future problems, or during the solution if and when problems become apparent. A new “unblocking” strategy is suggested which attempts to directly address the issue of blocking by performing sensitivity analysis on the Newton step with the aim of increasing the size of the step that can be taken. This analysis is used in a new technique to warmstart interior point methods: we identify components of the starting point that are responsible for blocking and aim to improve these by using our sensitivity analysis. The relative performance of a selection of different warmstarting techniques suggested in the literature and the new proposed unblocking by sensitivity analysis is evaluated on the warmstarting test set based on a selection of NETLIB problems proposed by [Benson and Shanno, Comput. Optim. Appl. , 38 (2007), pp. 371-399]. Warmstarting techniques are also applied in the context of solving nonlinear programming problems as a sequence of quadratic programs solved by interior point methods. We also apply the warmstarting technique to the problem of finding the complete efficient frontier in portfolio management problems (a problem with 192 million variables—to our knowledge the largest problem to date solved by a warmstarted IPM). We find that the resulting best combined warmstarting strategy manages to save between 50 and 60% of interior point iterations, consistently outperforming similar approaches reported in current optimization literature.
Decreased Effective Connectivity from Cortices to the Right Parahippocampal Gyrus in Alzheimer's Disease Subjects

The purpose of this study was to detect effective connectivity (EC) changes in the default mode network and hippocampus network in 20 patients with Alzheimer's disease (AD) and 20 cognitively normal (CN) subjects, using multivariate Granger causality. The authors used the maximum coefficients in the multivariate autoregression model to quantitatively measure the different EC strength levels between the CN and AD groups. It was demonstrated that the EC strength difference can classify AD from CN subjects. Further, the right parahippocampal gyrus (PHP_R) showed imbalanced bidirectional EC connections. The PHP_R received weaker input connections from the neocortices, but its output connections were significantly increased in AD. These findings may provide neural physiological mechanisms for interpreting AD subjects' memory deficits during the encoding processes.
Expression of glutamate receptor subtypes in the spinal cord of control and mnd mice, a model of motor neuron disorder

We studied the expression and distribution of glutamate receptor subtypes in the spinal cord of mnd mice, a model of motor neuron disorders and neuronal ceroid lipofuscinosis, and control mice using immunocytochemistry and in situ hybridization. The constitutive subunit of the NMDA ionotropic glutamate receptor, NMDAR1, was expressed in all neurons of the grey matter and was not modified in the spinal cord of mnd mice in either its normal or phosphorylated form. The immunoreactivity of GluR2, but not its mRNA, was increased mainly in the substantia gelatinosa both in presymptomatic and in 8‐month‐old symptomatic mice, suggesting compensatory changes aimed at reducing the Ca2+ permeability of the receptor channel. In spinal cord of mnd mice, mRNA, and protein levels of GluR3 were low only at the symptomatic stage, possibly as a consequence of motor neuron dysfunction. This was not due to motoneuron degeneration, because the number of choline acetyltransferase (ChAT) immunopositive lumbar motor neurons and the ChAT activity in the spinal cord and hind leg muscles of symptomatic mnd mice were no different from control mice. GluR4 mRNA was increased throughout the grey matter, presumably in relation to the marked microglia activation reported in the grey matter of the lumbar spinal cord in mnd mice. These changes in ionotropic glutamate receptors may alter glutamatergic neurotransmission and play some role in the pathology of mnd mice. © 2002 Wiley‐Liss, Inc.
A pro-active routing protocol for continuous data dissemination in wireless sensor networks

Wireless sensor networks are ad hoc networks with severe resource constraints. These constraints preclude the use of traditional ad hoc protocols, and demand optimizations that incur in solutions specific to a class of applications. This article presents PROC, a protocol designed for continuous data dissemination networks, that interacts with the application to establish routes, allowing the application to reconfigure PROC on runtime. A performance evaluation in topologies varying from 50 to 200 nodes showed that PROC increases network lifetime around 7% to 12%, and has higher throughput than EAD and TinyOS Beaconing. Furthermore, PROC presents a softer performance degradation when the number of nodes in the network increases.
Male mice song syntax depends on social contexts and influences female preferences

In 2005, Holy and Guo advanced the idea that male mice produce ultrasonic vocalizations (USV) with some features similar to courtship songs of songbirds. Since then, studies showed that male mice emit USV songs in different contexts (sexual and other) and possess a multisyllabic repertoire. Debate still exists for and against plasticity in their vocalizations. But the use of a multisyllabic repertoire can increase potential flexibility and information, in how elements are organized and recombined, namely syntax. In many bird species, modulating song syntax has ethological relevance for sexual behavior and mate preferences. In this study we exposed adult male mice to different social contexts and developed a new approach of analyzing their USVs based on songbird syntax analysis. We found that male mice modify their syntax, including specific sequences, length of sequence, repertoire composition, and spectral features, according to stimulus and social context. Males emit longer and simpler syllables and sequences when singing to females, but more complex syllables and sequences in response to fresh female urine. Playback experiments show that the females prefer the complex songs over the simpler ones. We propose the complex songs are to lure females in, whereas the directed simpler sequences are used for direct courtship. These results suggest that although mice have a much more limited ability of song modification, they could still be used as animal models for understanding some vocal communication features that songbirds are used for.
Proteomic Analysis Reveals Differentially Regulated Protein Acetylation in Human Amyotrophic Lateral Sclerosis Spinal Cord

Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that primarily affects motor neurons in the brain and spinal cord. Histone deacetylase (HDAC) inhibitors have neuroprotective effects potentially useful for the treatment of neurodegenerative diseases including ALS; however, the molecular mechanisms underlying their potential efficacy is not well understood. Here we report that protein acetylation in urea-soluble proteins is differently regulated in post-mortem ALS spinal cord. Two-dimensional electrophoresis (2-DE) analysis reveals several protein clusters with similar molecular weight but different charge status. Liquid chromatography and tandem mass spectrometry (LC-MS/MS) identifies glial fibrillary acidic protein (GFAP) as the dominant component in the protein clusters. Further analysis indicates six heavily acetylated lysine residues at positions 89, 153, 189, 218, 259 and 331 of GFAP. Immunoprecipitation followed by Western blotting confirms that the larger form of GFAP fragments are acetylated and upregulated in ALS spinal cord. Further studies demonstrate that acetylation of the proteins additional to GFAP is differently regulated, suggesting that acetylation and/or deacetylation play an important role in pathogenesis of ALS.
High-resolution resistivity imaging of marine gas hydrate structures by combined inversion of CSEM towed and ocean-bottom receiver data

We present high-resolution resistivity imaging of gas hydrate pipe-like structures, as derived from marine controlled-source electromagnetic (CSEM) inversions that combine towed and ocean-bottom electric field receiver data, acquired from the Nyegga region, offshore Norway. Two-dimensional CSEM inversions applied to the towed receiver data detected four new prominent vertical resistive features that are likely gas hydrate structures, located in proximity to a major gas hydrate pipe-like structure, known as the CNE03 pockmark. The resistivity model resulting from the CSEM data inversion resolved the CNE03 hydrate structure in high resolution, as inferred by comparison to seismically constrained inversions. Our results indicate that shallow gas hydrate vertical features can be delineated effectively by inverting both ocean-bottom and towed receiver CSEM data simultaneously. The approach applied here can be utilised to map and monitor seafloor mineralisation, freshwater reservoirs, CO2 sequestration sites and near-surface geothermal systems.
Irregular flowering patterns in terrestrial orchids: theories vs. empirical data

Abstract. Empirical data on many species of terrestrial orchids suggest that their between-year flowering pattern is extremely irregular and unpredictable. A long search for the reason has hitherto proved inconclusive. Here we summarise and critically review the hypotheses that were put forward as explanations of this phenomenon: irregular flowering was attributed to costs associated with sexual reproduction, to herbivory, or to the chaotic behaviour of the system represented by difference equations describing growth of the vegetative and reproductive organs. None of these seems to explain fully the events of a transition from flowering one year to sterility or absence the next year. Data on the seasonal growth of leaves and inflorescence of two terrestrial orchid species, Epipactis albensis and Dactylorhiza fuchsii and our previous results are then used here to fill gaps in what has been published until now and to test alternative explanations of the irregular flowering patterns of orchids.
Pattern Formation in an Array of Oscillators with Electrical and Chemical Coupling

Weak coupling theory is applied to a model for firing waves in the procerebral lobe of the slug. Inhibitory synapses and electrical synapses have different synchronizing properties. We show that, in concert, these two types of coupling can cause a bifurcation to a patterned state from synchrony which ultimately develops into traveling waves. Normal forms for the bifurcation are computed, and the results are compared to numerical simulations of the phase models.