Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards semantic embedding in visual vocabulary

Visual vocabulary serves as a fundamental component in many computer vision tasks, such as object recognition, visual search, and scene modeling. While state-of-the-art approaches build visual vocabulary based solely on visual statistics of local image patches, the correlative image labels are left unexploited in generating visual words. In this work, we present a semantic embedding framework to integrate semantic information from Flickr labels for supervised vocabulary construction. Our main contribution is a Hidden Markov Random Field modeling to supervise feature space quantization, with specialized considerations to label correlations: Local visual features are modeled as an Observed Field, which follows visual metrics to partition feature space. Semantic labels are modeled as a Hidden Field, which imposes generative supervision to the Observed Field with WordNet-based correlation constraints as Gibbs distribution. By simplifying the Markov property in the Hidden Field, both unsupervised and supervised (label independent) vocabularies can be derived from our framework. We validate our performances in two challenging computer vision tasks with comparisons to state-of-the-arts: (1) Large-scale image search on a Flickr 60,000 database; (2) Object recognition on the PASCAL VOC database.
Comparison of pramipexole, fluoxetine, and placebo in patients with major depression

Pramipexole, a dopamine D2 receptor agonist, was tested in 174 patients with major depression, with or without melancholia and without psychotic features. Three daily dose levels (0.375 mg, 1.0 mg, and 5.0 mg) were compared to fluoxetine (Prozac) at 20 mg and placebo in a randomized, double‐blind, parallel‐group study. After a 1 week placebo run‐in period, patients were treated for 8 weeks, had a post‐study follow‐up (week 9), and were evaluated primarily with the Hamilton Psychiatric Rating Scale for Depression (HAM‐D), the Montgomery‐Asberg Depression Rating Scale (MADRS), and the Clinician's Global Impressions‐Severity of Illness scale (CGI‐SI). All patients who received one dose of study medication were included in the observed‐case analysis (no missing data were replaced). Results indicated that by endpoint (week 8), patients receiving pramipexole at the 1.0 mg per day dose had significant improvement over baseline compared to the placebo group by measure of the HAM‐D, MADRS, and CGI‐SI. Significant improvement in this dose group was seen at other timepoints as well. The most obvious improvement was seen in the pramipexole 5.0 mg group, although a substantial dropout rate for this group precluded statistical tests vs. placebo late in the study. Patients taking fluoxetine also showed significant improvements at endpoint on the MADRS and earlier in the study on the HAM‐D. No new or unusual safety concerns were generated during this study. Pramipexole helped safely alleviate the symptoms of depression at 1.0 mg per day and especially in those patients who could tolerate the escalation to 5 mg per day. Depression and Anxiety 11:58–65, 2000. © 2000 Wiley‐Liss, Inc
Alternatives to the Median Absolute Deviation

Abstract In robust estimation one frequently needs an initial or auxiliary estimate of scale. For this one usually takes the median absolute deviation MAD n = 1.4826 med, {|xi − med j x j |}, because it has a simple explicit formula, needs little computation time, and is very robust as witnessed by its bounded influence function and its 50% breakdown point. But there is still room for improvement in two areas: the fact that MAD n is aimed at symmetric distributions and its low (37%) Gaussian efficiency. In this article we set out to construct explicit and 50% breakdown scale estimators that are more efficient. We consider the estimator Sn = 1.1926 med, {med j | xi − xj |} and the estimator Qn given by the . 25 quantile of the distances {|xi − x j |; i < j}. Note that Sn and Qn do not need any location estimate. Both Sn and Qn can be computed using O(n log n) time and O(n) storage. The Gaussian efficiency of Sn is 58%, whereas Qn attains 82%. We study Sn and Qn by means of their influence functions, their b.
Community rescue in experimental metacommunities

Significance Global environmental change is challenging the adaptive capacity of entire ecological communities. Community rescue occurs when populations within a community evolve in response to an environmental stress that was initially lethal to all the constituent organisms. We studied how communities of soil microbes can extend the area they occupy to include conditions that were initially lethal, and how these communities can persist despite the degradation of environmental conditions. Our results suggest that entire communities have the potential to adapt to severe environmental stress. Community rescue is promoted by the initial diversity in the community, is more frequent among communities that have previously experienced intermediate sublethal levels of stress, and is facilitated by the dispersal of organisms across the landscape. The conditions that allow biodiversity to recover following severe environmental degradation are poorly understood. We studied community rescue, the recovery of a viable community through the evolutionary rescue of many populations within an evolving community, in metacommunities of soil microbes adapting to a herbicide. The metacommunities occupied a landscape of crossed spatial gradients of the herbicide (Dalapon) and a resource (glucose), whereas their constituent communities were either isolated or connected by dispersal. The spread of adapted communities across the landscape and the persistence of communities when that landscape was degraded were strongly promoted by dispersal, and the capacity to adapt to lethal stress was also related to community size and initial diversity. After abrupt and lethal stress, community rescue was most frequent in communities that had previously experienced sublethal levels of stress and had been connected by dispersal. Community rescue occurred through the evolutionary rescue of both initially common taxa, which remained common, and of initially rare taxa, which grew to dominate the evolved community. Community rescue may allow productivity and biodiversity to recover from severe environmental degradation.
Probabilistic Energy Management for Building Climate Comfort in Smart Thermal Grids with Seasonal Storage Systems

This paper presents an energy management framework for building climate comfort (BCC) systems interconnected in a grid via aquifer thermal energy storage (ATES) systems in the presence of two types of uncertainty (private and common). ATES can be used either as a heat source (hot well) or sink (cold well) depending on the season. We consider the uncertain thermal energy demand of individual buildings as a private uncertainty source and the uncertain common resource pool (ATES) between neighbors as a common uncertainty source. We develop a large-scale stochastic hybrid dynamical model to predict the thermal energy imbalance in a network of interconnected BCC systems together with mutual interactions between their local ATES. We formulate a finite-horizon mixed-integer quadratic optimization problem with multiple chance constraints at each sampling time, which is in general a non-convex problem and difficult to solve. We then provide a computationally tractable framework by extending the so-called robust randomized approach and offering a less conservative solution for a problem with multiple chance constraints. A simulation study is provided to compare completely decoupled, centralized and move-blocking centralized solutions. We also present a numerical study using a geohydrological simulation environment (MODFLOW) to illustrate the advantages of our proposed framework.
Investigation on Mechanical Behaviors for Bolted Connections in Carbon Steel and in Stainless Steel Using FEM

A finite element (FE) analysis with three-dimensional solid elements has been performed for estimating the structural behaviors of single shear bolted connections fabricated with cold-formed austenitic stainless steel by utilizing the existing test data for calibration. Failure and curling (out-of-plane deformation perpendicular to the direction of loading) criteria were proposed. Therefore, the failure mode and ultimate strength, predicted by FE analysis method, showed good agreements with those of experimental results. In this study, FE analyses for 10 test specimens fabricated with cold-formed carbon steel as well as stainless steel including failure mode of bolt shear fracture are carried out and the validity of numerical prediction for ultimate behaviors in cold-formed carbon steel bolted connections is also verified, based on the applicability of FE method for predicting the mechanical behaviors of bolted connections in cold-formed stainless steel. It is known from the coupon test results of steel materials that austenitic stainless (SUS304) steel has a higher tensile strength of material due to the effect of strength enhancements (considerable strain hardening) by means of cold-working process and much lower yield stress when compared to carbon steel. The influence of curling on the strength reduction of bolted connections is estimated quantitatively. In addition, characteristics of mechanical behaviors and the influence of curling in bolted connections between two different steel materials are compared through detailed investigation of FE analysis results.
Dense Egyptian fractions

Every positive rational number has representations as Egyptian fractions (sums of reciprocals of distinct positive integers) with arbitrarily many terms and with arbitrarily large denominators. However, such representations normally use a very sparse subset of the positive integers up to the largest denominator. We show that for every positive rational there exist representations as Egyptian fractions whose largest denominator is at most N and whose denominators form a positive proportion of the integers up to N, for sufficiently large N; furthermore, the proportion is within a small factor of best possible.
Management of cytopenias in patients with myelofibrosis treated with ruxolitinib and effect of dose modifications on efficacy outcomes

Purpose Ruxolitinib is an oral Janus kinase (JAK) 1/JAK2 inhibitor approved in the US for the treatment of intermediate-or high-risk myelofibrosis (MF). Because thrombopoietin and erythropoietin signal through JAK2, dose-dependent cytopenias are expected with treatment. In the COMFORT-I (COntrolled Myelofibrosis study with ORal JAK inhibitor Treatment I) trial, these cytopenias were effectively managed with dose adjustments. These analyses were conducted to evaluate the relationship between ruxolitinib titrated doses and changes in platelet count and hemoglobin level as well as efficacy measures. Patients and methods COMFORT-I was a randomized, placebo-controlled trial in 309 patients with intermediate-2 or high-risk MF and a platelet count ≥100 × 109/L. Ruxolitinib starting doses were 15 and 20 mg twice daily (bis in die [BID]) for patients with baseline platelet counts of 100–200 × 109/L and >200 × 109/L, respectively. Percentage changes from baseline to week 24 in spleen volume and MF-related symptoms were assessed in subgroups defined by final titrated dose (average daily dose during weeks 21 to 24). Results The median final titrated doses for patients starting at doses of 15 and 20 mg BID were 10 and 20 mg BID, respectively, at week 24. Most dose reductions occurred in the first 8–12 weeks of treatment and coincided with decreases in platelet count and hemoglobin level. Subsequently, platelet counts stabilized and hemoglobin levels gradually returned to near baseline levels (red blood cell transfusion rates followed a similar trend). Final titrated doses of ≥10 mg BID were associated with clinically meaningful improvements in MF-related symptoms that were comparable across doses, while marginally greater reductions in spleen volume were observed at higher doses. Conclusion This COMFORT-I analysis shows that dose-dependent cytopenias were effectively managed with ruxolitinib dose adjustments, and titrated doses of ≥10 mg BID were associated with clinically meaningful reductions in spleen volume and symptom improvement at week 24.
Sialic Acid-Binding Immunoglobulin-Like Lectin 7 Mediates Selective Recognition of Sialylated Glycans Expressed on Campylobacter jejuni Lipooligosaccharides

ABSTRACT siglecs are a family of sialic-acid binding immunoglobulin-like lectins mostly expressed by cells of the immune system that have the potential to interact with sialylated glycans expressed not only on host cells but also on certain pathogens. Campylobacter jejuni is a common pathogen of humans that expresses surface lipooligosaccharides (LOS) that can be modified with ganglioside-like terminal structures in the core oligosaccharides. In this study, we examined the interaction of 10 siglecs with LOS purified from four different C. jejuni isolates expressing GM1-like, GD1a-like, GD3-like, and GT1a-like oligosaccharides. Of all siglecs examined, only Siglec-7 exhibited specific, sialic acid-dependent interactions with C. jejuni LOS in solid-phase binding assays. Binding was especially prominent with LOS from the HS:19(GM1+ GT1a+) isolate, with weaker binding with LOS from the HS:19(GD3+) isolate. Binding of Siglec-7 was also observed with intact bacteria expressing these LOS structures. Specific binding of HS:19(GM1+ GT1a+) bacteria was demonstrated with Siglec-7 expressed on transfected Chinese hamster ovary cells and with peripheral blood leukocytes, among which HS:19(GM1+ GT1a+) bacteria bound selectively to both natural killer cells and monocytes which naturally express Siglec-7. These results raise the possibility that, in addition to their role in generating autoimmune antibody responses, C. jejuni LOS could interact with Siglec-7 expressed by leukocytes, modulate the host-pathogen interaction, and contribute to the clinical outcome and the development of secondary complications such as Guillain-Barré syndrome.
High-Precision Robust Force Control of a Series Elastic Actuator

A series elastic actuator (SEA) is a promising actuation method in force control applications that intelligently interacts with environments. The SEA is characterized by a spring placed between a load and an actuator, which is an electric motor in most cases. Since the spring plays the role of a transducer between position (i.e., the spring deflection) and force, it is able to control the output force (torque) precisely by utilizing typical position control methods. However, the force control performance of the SEA is considered to have limitations due to its elasticity, and thus, to be inferior to rigid actuators in terms of bandwidth. This paper proposes that the force control performance of the SEA can be improved by exploiting the dynamic model of the SEA. To this end, the SEA is modeled and analyzed utilizing the two-mass dynamic model, which is a well-known and widely accepted model of the flexible system. The disturbance observer and feedforward controller are introduced as the model-based control algorithms for the SEA to achieve the high-precision force control. In addition to high-bandwidth force control, the proposed controller can address the robust stability and performance against model parameter variance and exogenous disturbances. For the analytic and quantitative assessment of the proposed force control system, the dynamic characteristics of an SEA under various control algorithms are analyzed, and the experimental results are provided for an actual SEA system in this paper.
Action–perception coupling in pianists: Learned mappings or spatial musical association of response codes (SMARC) effect?

The principle of common coding suggests that a joint representation is formed when actions are repeatedly paired with a specific perceptual event. Musicians are occupationally specialized with regard to the coupling between actions and their auditory effects. In the present study, we employed a novel paradigm to demonstrate automatic action–effect associations in pianists. Pianists and nonmusicians pressed keys according to aurally presented number sequences. Numbers were presented at pitches that were neutral, congruent, or incongruent with respect to pitches that would normally be produced by such actions. Response time differences were seen between congruent and incongruent sequences in pianists alone. A second experiment was conducted to determine whether these effects could be attributed to the existence of previously documented spatial/pitch compatibility effects. In a “stretched” version of the task, the pitch distance over which the numbers were presented was enlarged to a range that could not be produced by the hand span used in Experiment 1. The finding of a larger response time difference between congruent and incongruent trials in the original, standard, version compared with the stretched version, in pianists, but not in nonmusicians, indicates that the effects obtained are, at least partially, attributable to learned action effects.
Epithelial-mesenchymal interactions in the pathogenesis of asthma

ABSTRACT Asthma is regarded as an inflammatory disorder of the conducting airways characterized by a mast cell, eosinophil and T lymphocyte inflammatory response that is responsive to anti-inflammatory therapy, such as corticosteroids. In more severe and chronic disease, corticosteroids become less effective. As in other chronic inflammatory diseases, the tissue in which the cellular and mediator processes occur plays a major role in maintaining the response and creating a basis for disease persistence. Herein, we describe evidence that the airway epithelium interacting with the underlying mesenchymal cells recapitulates branching morphogenesis, as observed in the developing lung, to create airway wall remodeling. The reciprocal signaling between the susceptible epithelium and responsive mesenchyme (epithelial mesenchymal trophic unit) offers a new paradigm for asthma and creates new opportunities for developing therapeutics based on reversing the 'chronic wound' phenotype of asthmatic airways.
Designing and Building Expressive Robotic Guitars

This paper provides a history of robotic guitars and bass guitars as well as a discussion of the design, construction, and evaluation of two new robotic instruments. Throughout the paper, a focus is made on different techniques to extend the expressivity of robotic guitars. Swivel and MechBass, two new robots, are built and discussed. Construction techniques of likely interest to other musical roboticists are included. These robots use a variety of techniques, both new and inspired by prior work, to afford composers and performers with the ability to precisely control pitch and plucking parameters. Both new robots are evaluated to test their precision, repeatability, and speed. The paper closes with a discussion of the compositional and performative implications of such levels of control, and how it might affect humans who wish to interface with the systems.
Deferred radiotherapy and upfront procarbazine–ACNU–vincristine administration for 1p19q codeleted oligodendroglial tumors are associated with favorable outcome without compromising patient performance, regardless of WHO grade

Recently updated phase III trials revealed the favorable effect of add-on procarbazine-lomustine-vincristine chemotherapy (CT) to radiotherapy (RT) in treating anaplastic oligodendrogliomas with 1p19q codeletion (codel). However, the underlying rationality of deferring RT and upfront CT administration for these tumors is yet to be elucidated. Here, we retrospectively analyzed the long-term outcome of our case series with oligodendroglial tumors treated with deferred RT and upfront procarbazine+nimustine+vincristine (PAV) in the introduction administration. We enrolled 36 patients with newly diagnosed oligodendroglial tumors (17, grade II and 19, grade III) treated during 1999–2012 and followed up for a median period of 69.0 months. Their clinical and genetic prognostic factors were analyzed, and progression-free survival, overall survival (OS), and deterioration-free survival (DFS) were evaluated. Regardless of the WHO grade, the 25 patients with 1p19q codel tumors never received RT initially, and of these 25, 23 received PAV treatment upfront. The 75% OS of patients with 1p19q codel tumor was 135.3 months (did not reach the median OS), indicating a favorable outcome. Multivariate analysis revealed that IDH mutation and 1p19q, not WHO grade, are independent prognostic factors; furthermore, IDH and 1p19q status stratified the cohort into 3 groups with significantly different OS. The DFS explained the prolonged survival without declining performance in patients with both grade II and III 1p19q codel tumors. Deferred RT and upfront PAV treatment for 1p19q codel oligodendrogliomas were associated with favorable outcomes without compromising performance status, regardless of WHO grade.
NEUROREGENERATIVE EFFECTS OF D-α-TOCOPHEROL ON THE CRUSHED SCIATIC NERVE OF DIABETIC RATS

ABSTRACT Objective: This present study is designed to explore the neuroregenerative effects of d-α-tocopherol on peripheral nerve in both healthy and diabetic rats. Methods: 24 albino rats were divided into four groups; healthy control, diabetic control, healthy treated, and diabetic treated. Diabetes was induced by single subcutaneous injection of alloxan (100 mg/kg). Treated groups were administered d-α-tocopherol orally, daily (200 mg/kg) for 3 weeks. Through a mid-thigh incision, sciatic nerve was crushed with Kocher’s forceps, and skin wound was closed with absorbable suture. Sciatic functional and static indices were used to assess the functional recovery in conjunction with histological, histomorphological, and biochemical analyses at the end of 3 weeks. Results: It was noticed that d-α-tocopherol supplementation accelerates functional recovery, enhances the antioxidant levels, and promotes the regeneration and extracellular matrix reorganization of peripheral nerves. Conclusion: It is concluded that the d-α-tocopherol appears to be an optimistic option in the management of peripheral nerve crush injury in both healthy and diabetics. Keywords: Antioxidant, d-α-tocopherol, Diabetes, Rats, Regeneration, Sciatic nerve.
Novel drug delivery systems for inner ear protection and regeneration after hearing loss

Background: A cochlear implant, the only current treatment for restoring auditory perception after severe or profound sensorineural hearing loss (SNHL), works by electrically stimulating spiral ganglion neurons (SGNs). However, gradual degeneration of SGNs associated with SNHL can compromise the efficacy of the device. Objective: To review novel drug delivery systems for preserving and/or regenerating sensory cells in the cochlea after SNHL. Methods: The effectiveness of traditional cochlear drug delivery systems is compared to newer techniques such as cell, polymer and gene transfer technologies. Special requirements for local drug delivery to the cochlea are discussed, such as protecting residual hearing and site-specific drug delivery for cell preservation and regeneration. Results/conclusions: Drug delivery systems with the potential for immediate clinical translation, as well as those that will contribute to the future of hearing preservation or cochlear cellular regeneration, are identified.