Miracle-dz/UniFAR-FTUs huggingface dataset:
INSIGHTS INTO SPOKEN LANGUAGE GLEANED FROM PHONETIC TRANSCRIPTION OF THE SWITCHBOARD CORPUS

Models of speech recognition (by both human and machine) have traditionally assumed the phoneme to serve as the fundamental unit of phonetic and phonological analysis. However, phoneme-centric models have failed to provide a convincing theoretical account of the process by which the brain extracts meaning from the speech signal and have fared poorly in automatic recognition of natural, informal speech (e.g., the Switchboard corpus). Over the past five months the Switchboard Transcription Project has phonetically transcribed a portion of the Switchboard corpus in an effort to better understand the failure of phoneme-centric models for machine recognition of speech, as well as to provide a database through which to improve the performance of recognition systems focused on conversational dialogs. Transcription of spoken dialogs illustrates the pitfalls of a phoneme-based system. Many words are articulated in such a fashion as to either omit or significantly transform the phonetic properties of phonemic constituents, thus resulting i n wide variation of word pronunciations. Often, only the barest hint of a segment is realized phonetically, in spite of good intelligibility. Despite this large variability in phonetic realization of words, the temporal properties of speech segments, both phones and syllables, appear to conform to regular patterns. This temporal regularity suggests that much of the linguistic information i n speech may be signaled through variations in amplitude, pitch and the coarse spectrum, and that such patterns may be useful i n the design of future-generation speech recognition systems.
imilarity to the self affects memory for impressions of others

The present studies investigated whether similarity to the self influenced memory for impressions of others. We predicted that similarity to the self would facilitate impression memory for others, paralleling the self-reference effect found when information is processed relative to the self. We were interested in how the initial valence of the impression, whether positive or negative, affected impression memory. Across two experiments, participants formed impressions while viewing faces paired with traits and behaviors. After recognition, participants rated the self-descriptiveness of the studied traits allowing impression memory to be sorted into high-, medium-, and low-self-similarity. For positive impressions,
Information-theoretically Secure Key Agreement over Partially Corrupted Channels

Key agreement is a fundamental cryptographic primitive. It has been proved that key agreement protocols with security against computationally unbounded adversaries cannot exist in a setting where Alice and Bob do not have dependent variables and communication between them is fully public, or fully controlled by the adversary. In this paper we consider this problem when the adversary can "partially" control the channel. We motivate these adversaries by considering adversarial corruptions at the physical layer of communication, give a definition of adversaries that can "partially" eavesdrop and "partially" corrupt the communication. We formalize security and reliability of key agreement protocols, derive bounds on the rate of key agreement, and give constructions that achieve the bound. Our results show that it is possible to have secret key agreement as long as some of the communicated symbols remain private and unchanged by the adversary. We relate our results to the previous known results, and discuss future work.
Caudal Granular Insular Cortex Is Sufficient and Necessary for the Long-Term Maintenance of Allodynic Behavior in the Rat Attributable to Mononeuropathy

Mechanical allodynia, the perception of innocuous tactile stimulation as painful, is a severe symptom of chronic pain often produced by damage to peripheral nerves. Allodynia affects millions of people and remains highly resistant to classic analgesics and therapies. Neural mechanisms for the development and maintenance of allodynia have been investigated in the spinal cord, brainstem, thalamus, and forebrain, but manipulations of these regions rarely produce lasting effects. We found that long-term alleviation of allodynic manifestations is produced by discreetly lesioning a newly discovered somatosensory representation in caudal granular insular cortex (CGIC) in the rat, either before or after a chronic constriction injury of the sciatic nerve. However, CGIC lesions alone have no effect on normal mechanical stimulus thresholds. In addition, using electrophysiological techniques, we reveal a corticospinal loop that could be the anatomical source of the influence of CGIC on allodynia.
Fast and accurate instruction fetch and branch prediction

Accurate branch prediction is critical to performance; mispredicted branches mean that ten's of cycles may be wasted in superscalar architectures. Architectures combining very effective branch prediction mechanisms coupled with modified branch target buffers (BTB's) have been proposed for wide-issue processors. These mechanisms require considerable processor resources. Concurrently, the larger address space of 64-bit architectures introduce new obstacles and opportunities. A larger address space means branch target buffers become more expensive. The authors show how a combination of less expensive mechanisms can achieve better performance than BTB's. This combination relies on a number of design choices described in the paper. They used trace-driven simulation to show that their proposed design, which uses fewer resources, offers better performance than previously proposed alternatives for most programs, and indicate how to further improve this design. <<ETX>>
Can Musical Training Influence Brain Connectivity? Evidence from Diffusion Tensor MRI

In recent years, musicians have been increasingly recruited to investigate grey and white matter neuroplasticity induced by skill acquisition. The development of Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) has allowed more detailed investigation of white matter connections within the brain, addressing questions about the effect of musical training on connectivity between specific brain regions. Here, current DT-MRI analysis techniques are discussed and the available evidence from DT-MRI studies into differences in white matter architecture between musicians and non-musicians is reviewed. Collectively, the existing literature tends to support the hypothesis that musical training can induce changes in cross-hemispheric connections, with significant differences frequently reported in various regions of the corpus callosum of musicians compared with non-musicians. However, differences found in intra-hemispheric fibres have not always been replicated, while findings regarding the internal capsule and corticospinal tracts appear to be contradictory. There is also recent evidence to suggest that variances in white matter structure in non-musicians may correlate with their ability to learn musical skills, offering an alternative explanation for the structural differences observed between musicians and non-musicians. Considering the inconsistencies in the current literature, possible reasons for conflicting results are offered, along with suggestions for future research in this area.
Wireless Powered Asynchronous Backscatter Networks With Sporadic Short Packets: Performance Analysis and Optimization

In the fifth generation era, the pervasive applications of Internet of Things and massive machine-type communications have initiated increasing research interests on the backscatter wireless powered communication (B-WPC) technique due to its ultrahigh energy efficiency and low cost. The ubiquitous B-WPC network is characterized by nodes with dynamic spatial positions and sporadic short packets, of which the performance has not been fully investigated. In this paper, we give a comprehensive analysis of a multiantenna B-WPC network with sporadic short packets under a stochastic geometry framework. By exploiting a time-space Poisson point process model, the behavior of the network is well captured in a decentralized and asynchronous transmission way. We then analyze the energy and information outage performance in the energy harvest and backscatter modulation phases of the backscatter network, respectively. The optimal transmission slot length and division are obtained by maximizing the network-wide spatial throughput. Moreover, we find an interesting result that there exists the optimal tradeoff between the durations of the energy harvest and backscatter modulation phases for spatial throughput maximization. Numerical results are demonstrated to verify our analytical findings and show that this tradeoff region gets shrunk when the outage constraints become more stringent.
Interrelationship of Pyrogenic Polycyclic Aromatic Hydrocarbon (PAH) Contamination in Different Environmental Media

Interrelationships between pyrogenic polycyclic aromatic hydrocarbons (PAHs) were assessed in air, soil, water, sediment, and tree leaves by using multi-media monitoring data. Concurrent concentration measurements were taken bimonthly for a year for the multi-media at urban and suburban sites. PAH level correlations between air and other media were observed at the urban site but were less clear at the suburban site. Considering a closer PAHs distribution/fate characteristics to soil than suspended solids, contamination in sediment seemed to be governed primarily by that in soil. The partitioning of PAHs in waters could be better accounted for by sorption onto black carbon and dissolved organic carbon.
Slack-Based Heuristics for Constraint Satisfaction Scheduling

In this paper, we define and empirically evaluate new heuristics for solving the job shop scheduling problem with non-relaxable time windows. The hypothesis underlying our approach is that by approaching the problem as one of establishing sequencing constraints between pairs of operations requiring the same resource (as opposed to a problem of assigning start times to each operation) and by exploiting previously developed analysis techniques for limiting search through the space of possible sequencing decisions, simple, localized look-ahead techniques can yield problem solving performance comparable to currently dominating techniques that rely on more sophisticated analysis of resource contention. We define a series of attention focusing heuristics based on simple analysis of the temporal flexibility associated with different sequencing decisions, and a similarly motivated heuristic for determining how to sequence a given operation pair. Performance results are reported on a suite of benchmark problems previously investigated by two advanced approaches, and our simplified look-ahead analysis techniques are shown to provide comparable problem solving leverage at reduced computational cost.
An Innovative Cold Tail-Flick Test: The Cold Ethanol Tail-Flick Test

An innovative antinociceptive test, the cold ethanol tail-flick test (CET), was developed for evaluating the actions of opioid analgesics. To select an optimal operation temperature range for the CET, temperatures from -5 degrees C to -30 degrees C were screened. After screening, temperatures ranging between -20 degrees C and -30 degrees C were both strong and effective enough to act as a noxious cold stimulus. In the following study, -20 degrees C was selected as the cold stimulus for the CET. The sensitivity and specificity of this test were challenged by opioid analgesics: an agonist (morphine) and two agonist-antagonists (buprenorphine and nalbuphine), two tranquilizers (droperidol and diazepam), and four nonopioid analgesics (acetaminophen, aspirin, indomethacin, and ketoprofen). The sensitivity of the CET was also compared with the assays using heat (radiant heat and hot water). The AD50 values determined by the CET for morphine, buprenorphine, and nalbuphine were 0.16 mg/kg, 0.22 micro gram/kg, and 0.19 mg/kg, respectively. Naloxone, an opioid antagonist, blocked the antinociceptive effects of these opioids which were determined by the CET. Furthermore, the tranquilizers and nonopioid analgesics did not show any activity in the CET. Our results show that not only can the CET assess the antinociceptive activity of both opioid agonist and mixed agonist-antagonist, it also possess the characteristics of sensitivity, specificity, simplicity, and reproducibility. (Anesth Analg 1995;80:102-7)
New Type II String Theories with Sixteen Supercharges

We present two new backgrounds of type IIA string theory preserving 16 supercharges. One is a Wilson line for (-1) to the left-moving spacetime fermion number, and the other is an orbifold by a reflection of four coordinates, along with the action of (-1) to the left-moving spacetime fermion number. The Wilson line theory has many new phenomena, including a self-duality of type IIA on a single circle, enhanced gauge symmetry at the self-dual radius, and a T-duality between uncharged and (locally) charged branes. The orbifold theory also presents many novel features, including charged, stable non-BPS D1, D3, and D5-branes pinned to the fixed locus, and an instability of the D0-brane near the fixed locus.
Niacin lowers serum phosphate and increases HDL cholesterol in dialysis patients.

BACKGROUND AND OBJECTIVES Adverse effects complicate the use of drugs that are prescribed for phosphate control in dialysis patients. Alternative treatment options are needed. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Nicotinic acid inhibits intestinal phosphate reabsorption and increases HDL cholesterol. This study tested the phosphate-lowering and HDL-increasing effect of Niaspan (prolonged-release nicotinic acid) in patients who were undergoing dialysis. Efficacy, safety, and tolerability of Niaspan were prospectively studied. Twenty dialysis patients, who were receiving a stable dosage of a calcium salt-containing drug for phosphate control, received after a 2-wk washout period Niaspan for 12 wk. Patients were started on 375 mg/d, and the dosage was increased every 2 wk to achieve 500, 1000, 1500, and 2000 mg/d, respectively. Clinical and laboratory parameters were prospectively recorded in patients who tolerated a target dosage of > or = 1000 mg/d. RESULTS Seventeen patients tolerated > or = 1000 mg/d Niaspan (mean dosage 1470 +/- 110 mg/d). Niaspan treatment for 12 wk decreased serum phosphate values from 7.2 +/- 0.5 to 5.9 +/- 0.6 mg/dl (P < 0.015). In contrast, Niaspan did not affect serum calcium levels. A significant increase in HDL cholesterol from 40 +/- 3.2 to 59 +/- 5.5 mg/dl (34%) was also observed with Niaspan (P = 0.0005). CONCLUSIONS Niaspan effectively lowered serum phosphate levels and significantly increased HDL cholesterol. Niaspan may provide an alternative or adjunctive treatment option in dialysis patients.
Using a combined index of native and non-native plant diversity for estimating ecosystem and environmental change over time and space

Today’s plant communities are the result of long-term interactions between vegetation and site factors including man-made impacts. Current species diversity reflects historical as well as environmental factors since environmental change and human activities lead to changes in species composition and competition through biological invasions. It means that biodiversity as an indicator for the well-being of ecosystems must consider the effects of invaders on an ecosystem. On the other hand, the existing methods for biodiversity index can not be used directly for cross-scale evaluation of vegetation. Hence, we proposed a 3-dimensional model derived from a logistic equation for calculating a combined index of native and non-native plant diversity for estimating ecosystem/environmental change. The two variables, based on the current and the theoretical maximum diversity of native and non-native plants on a given scale, and the result of the model are relative values without units and are therefore scale-
Simulation of 1D Abrasive Vibratory Finishing Process

The vibratory finishing process involves three dimensional motion of abrasive media interacting with part surfaces. With the ultimate goal of simulating such media motion in laboratory conditions, we present here a first step that makes use of a tribometer’s recipricating drive to provide one dimensional controlled vibrations. Finishing experiments using this setup are conducted using abrasive media and titanium alloy work material, both of the type typically used in aerospace industry. Material removal rates, surface roughness and contact forces are measured in two different setups. The media motion is also modelled using multi-body dynamics to predict the contact forces between the media and the work surface. Experimental results are seen to follow literature reported and model predicted trends. This work paves the way for a true three dimensional simulator for a vibratory finishing process.
A Predictive Risk Model for A(H7N9) Human Infections Based on Spatial-Temporal Autocorrelation and Risk Factors: China, 2013–2014

This study investigated the spatial distribution, spatial autocorrelation, temporal cluster, spatial-temporal autocorrelation and probable risk factors of H7N9 outbreaks in humans from March 2013 to December 2014 in China. The results showed that the epidemic spread with significant spatial-temporal autocorrelation. In order to describe the spatial-temporal autocorrelation of H7N9, an improved model was developed by introducing a spatial-temporal factor in this paper. Logistic regression analyses were utilized to investigate the risk factors associated with their distribution, and nine risk factors were significantly associated with the occurrence of A(H7N9) human infections: the spatial-temporal factor φ (OR = 2546669.382, p < 0.001), migration route (OR = 0.993, p < 0.01), river (OR = 0.861, p < 0.001), lake(OR = 0.992, p < 0.001), road (OR = 0.906, p < 0.001), railway (OR = 0.980, p < 0.001), temperature (OR = 1.170, p < 0.01), precipitation (OR = 0.615, p < 0.001) and relative humidity (OR = 1.337, p < 0.001). The improved model obtained a better prediction performance and a higher fitting accuracy than the traditional model: in the improved model 90.1% (91/101) of the cases during February 2014 occurred in the high risk areas (the predictive risk > 0.70) of the predictive risk map, whereas 44.6% (45/101) of which overlaid on the high risk areas (the predictive risk > 0.70) for the traditional model, and the fitting accuracy of the improved model was 91.6% which was superior to the traditional model (86.1%). The predictive risk map generated based on the improved model revealed that the east and southeast of China were the high risk areas of A(H7N9) human infections in February 2014. These results provided baseline data for the control and prevention of future human infections.
miR-6734 Up-Regulates p21 Gene Expression and Induces Cell Cycle Arrest and Apoptosis in Colon Cancer Cells

Recently, microRNAs have been implicated in the regulation of gene expression in terms of both gene silencing and gene activation. Here, we investigated the effects of miR-6734, which has a sequence homology with a specific region of p21WAF1/CIP1 (p21) promoter, on cancer cell growth and the mechanisms involved in this effect. miR-6734 up-regulated p21 expression at both mRNA and protein levels and chromatin immunoprecipitation analysis using biotin-labeled miR-6734 confirmed the association of miR-6734 with p21 promoter. Moreover, miR-6734 inhibited cancer cell growth and induced cell cycle arrest and apoptosis in HCT-116 cells, which was abolished by knockdown of p21. The phosphorylation of Rb and the cleavage of caspase 3 and PARP were suppressed by miR-6734 transfection in HCT-116 cells and these effects were also reversed by p21 knockdown. In addition, miR-6734 transfection caused prolonged induction of p21 gene and modification of histones in p21 promoter, which are typical aspects of a phenomenon referred to as RNA activation (RNAa). Collectively, our results demonstrated that miR-6734 inhibits the growth of colon cancer cells by up-regulating p21 gene expression and subsequent induction of cell cycle arrest and apoptosis, suggesting its role as an important endogenous regulator of cancer cell proliferation and survival.
MCL-1, BCL-XL and MITF Are Diversely Employed in Adaptive Response of Melanoma Cells to Changes in Microenvironment

Melanoma cells can switch their phenotypes in response to microenvironmental insults. Heterogeneous melanoma populations characterized by long-term growth and a high self-renewal capacity can be obtained in vitro in EGF(+)bFGF(+) medium whilst invasive potential of melanoma cells is increased in serum-containing cultures. In the present study, we have shown that originally these patient-derived melanoma populations exhibit variable expression of pro-survival genes from the BCL-2 family and inhibitors of apoptosis (IAPs), and differ in the baseline MCL-1 transcript stability as well. While being transferred to serum-containing medium, melanoma cells are well protected from death. Immediate adaptive response of melanoma cells selectively involves a temporary MCL-1 increase, both at mRNA and protein levels, and BCL-XL can complement MCL-1, especially in MITFlow populations. Thus, the extent of MCL-1 and BCL-XL contributions seems to be cell context-dependent. An increase in MCL-1 level results from a transiently enhanced stability of its transcript, but not from altered protein turnover. Inhibition of MCL-1 preceding transfer to serum-containing medium caused the induction of cell death in a subset of melanoma cells, which confirms the involvement of MCL-1 in melanoma cell survival during the rapid alteration of growth conditions. Additionally, immediate response to serum involves the transient increase in MITF expression and inhibition of ERK-1/2 activity. Uncovering the mechanisms of adaptive response to rapid changes in microenvironment may extend our knowledge on melanoma biology, especially at the stage of dissemination.
Monaural Beamforming in Bimodal Cochlear Implant Users: Effect of (A)symmetric Directivity and Noise Type

Objective To evaluate monaural beamforming in bimodally aided cochlear implant (CI) users. Design The study enrolled twelve adult bimodal listeners with at least six months of CI-experience and using a contralateral hearing aid (HA) most of the daytime. Participants were uniformly fitted with the same CI speech processor and HA, giving access to an identical monaural beamformer in both ears. A within-subject repeated measures design evaluated three directional configurations [omnidirectional, asymmetric directivity (in CI alone) and symmetric directivity (in both CI and HA)] in two noise types [stationary and fluctuating]. Bimodal speech reception thresholds (SRT) as well as listening effort ratings were assessed in a diffuse noise field. Results Symmetric monaural beamforming provided a significant SRT improvement of 2.6 dB SNR, compared to 1.6 dB SNR for asymmetric monaural beamforming. Directional benefits were similarly observed in stationary and fluctuating noise. Directivity did not contribute to less listening effort in addition to improvement in speech intelligibility. Bimodal performance was about 7 dB SNR worse in fluctuating than in stationary noise. Conclusions Monaural beamforming provided substantial benefit for speech intelligibility in noise for bimodal listeners. The greatest benefit occurred when monaural beamforming was activated symmetrically in both CI and HA. Monaural beamforming does not bridge the gap between bimodal and normal hearing performance, especially in fluctuating noise. Results advocate further bimodal co-operation. Trial Registration This trial was registered in www.trialregister. nl under number NTR4901.