Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of radiation therapy on oesophageal transit in patients with inner quadrant breast tumour

ObjectivesThe aim of this study was to evaluate quantitatively the effect of low doses of radiation therapy on the oesophageal transit in patients with inner quadrant breast carcinoma. MethodsEighteen female patients with locally advanced inner quadrant breast tumour were included in this study. A total dose of 5000 cGy in 25 fractions of 200 cGy was applied from four different treatment portals to all patients. Oesophageal motility was evaluated before and immediately after radiotherapy using oesophageal scintigraphy. The oesophageal transit times (ETTs) for the upper one-third, the lower two-thirds portion and the whole oesophagus were calculated. ResultsThe upper one-third portion of the oesophagus received a mean dose of 600 cGy and the lower two-thirds portion received a mean dose of 1530 cGy as a result of 5000 cGy dose application. All of the patients developed grade 1 oesophageal toxicity. Post-radiation therapy ETT values were significantly higher compared to pre-radiation therapy ETT values (P<0.001). Before irradiation, ETT values for the upper one-third, distal two-thirds of the oesophagus and the whole oesophagus were 4.77±1.08, 11.22±2.85 and 11.61±2.97 s, respectively. After irradiation, ETT values for the upper one-third, distal two-thirds of the oesophagus and the whole oesophagus were 6.92±2.15, 23.30±5.65 and 23.74±5.70 s, respectively. ConclusionsOesophageal transit seems to be affected by radiation even without a clinically significant oesophageal symptom and oesophageal scintigraphy allows sensitive, non-invasive and quantifiable assessment of the oesophageal transit time.
Demutualization and Public Offerings of Financial Exchanges

Almost all exchanges around the world were member-owned, organized as "non-profit, mutual" organizations, until the early 1990s. However, the last 10 years have seen a dramatic change in the organizational structure of exchanges as they have demutualized and evolved into "for-profit" entities usually owned by investors rather than just members. This demutualization process is frequently accompanied by a public listing of shares allowing for wide spread ownership. These are major changes for a sector that plays a critical role in the financial markets and the capital raising process. We argue that these changes are being driven by technological, regulatory and industry specific factors and should have wide ranging consequences both for the exchanges as well as market participants. We find that demutualized exchanges have performed well both in terms of returns to shareholders and operating performance. However, demutualization is a relatively recent phenomenon with limited history and therefore the results must be interpreted cautiously.
Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty

Frailty is a complex aging phenotype associated with increased vulnerability to disability and death. Understanding the biological antecedents of frailty may provide clues to healthy aging. The genome-wide association study hotspot, 9p21-23 region, is a risk locus for a number of age-related complex disorders associated with frailty. Hence, we conducted an association study to examine whether variations in 9p21-23 locus plays a role in the pathogenesis of frailty in 637 community-dwelling Ashkenazi Jewish adults aged 65 and older enrolled in the LonGenity study. The strongest association with frailty (adjusted for age and gender) was found with the SNP rs518054 (odds ratio: 1.635, 95% CI = 1.241–2.154; p-value: 4.81 × 10−04) intergenic and located between LOC105375977 and C9orf146. The prevalence of four SNPs (rs1324192, rs7019262, rs518054, and rs571221) risk alleles haplotype in this region was significantly higher (compared with other haplotypes) in frail older adults compared with non-frail older adults (29.7 vs. 20.8%, p = 0.0005, respectively). Functional analyses using in silico approaches placed rs518054 in the CTCF binding site as well as DNase hypersensitive region. Furthermore, rs518054 was found to be in an enhancer site of NFIB gene located downstream. NFIB is a transcription factor that promotes cell differentiation during development, has antiapoptotic effect, maintains stem cell populations in adult tissues, and also acts as epigenetic regulators. Our study found novel association of SNPs in the regulatory region in the 9p21-23 region with the frailty phenotype; signifying the importance of this locus in aging.
Calcitonin gene-related peptide in secretory granules of serous cells in the rat tracheal epithelium.

The tracheal epithelium of pathogen-free rats consists mainly of serous-type secretory cells, ciliated cells, basal cells, and a few neuroendocrine cells. Mucus-containing goblet cells are rare. Calcitonin gene-related peptide (CGRP) is known to exist in the neuroendocrine cells and in sensory nerves of the tracheal mucosa and is released into the airway lumen by sensory nerve stimulation. In this study, we determined whether epithelial serous cells are another source of CGRP. Tracheas of adult male specific pathogen-free F344 rats were immunostained by an avidin-biotin technique either as whole mounts or as cryostat sections using two different polyclonal primary antibodies to rat CGRP. Some specimens were stained for CGRP-like immunofluorescence and examined with a confocal microscope. CGRP immunoreactivity was present in granules of serous cells throughout the trachea. In whole mounts, the stained cells were most abundant between the cartilaginous rings, especially in the rostral trachea, where they constituted 56% of the epithelial cells in contact with the tracheal lumen. Serous cells were easily distinguished from neuroendocrine cells and nerve fibers with CGRP immunoreactivity. In evidence that the CGRP immunoreactivity was specific, the staining of serous cells was abolished by omitting the primary antibody and by absorption with 10 micrograms/ml CGRP. Antibodies to substance P, vasoactive intestinal polypeptide, and tyrosine hydroxylase did not stain epithelial serous cells. An antibody to protein gene product 9.5 labeled neuroendocrine cells, but not serous cells. Injection of capsaicin (150 micrograms/kg intravenously), a substance known to degranulate epithelial serous cells, reduced the staining of the serous cells for CGRP. (ABSTRACT TRUNCATED AT 250 WORDS)
DNA taxonomy, phylogeny and Pleistocene diversification of the Cicindela hybrida species group (Coleoptera: Cicindelidae)

Species delimitation is complicated where morphological variation is continuous or poorly subdivided, but for taxonomic convenience it is common practice to separate and name geographical groups to capture this variation. DNA‐based approaches may be used to test if these groups in fact represent historically divided, discrete species entities. The Cicindela hybrida complex (Coleoptera: Cicindelidae) is an assemblage of up to seven morphologically recognized species and 15 subspecies with wide distribution in the Palaearctic region. We sequenced a discontinuous segment of 1899 bp of mtDNA including three regions (coxI, rrnL+trnL2+nad1, cob) for a total of 99 specimens from 36 sampling localities across Europe, revealing 48 haplotypes. Four major clades could be identified corresponding to geographical groups from central Iberia, Ukraine, central Europe, and a band from the Atlantic Iberian coast to northern Europe. Taking into account further subdivisions within these clades, four of the six named species included in the analysis were recognizable by applying various procedures for species delimitation. Age estimates from calibrated molecular clocks date the diversification of the hybrida group within the past 2 million years (Myr), and the separation of the northern clade within 0.4 Myr. Nested clade analysis revealed the rapid range expansion of the northern group consistent with postglacial dispersal, but we did not find support for specific source population(s) in the postulated southern refugia. The evolutionary framework based on mtDNA sequences is shown to identify species entities as discrete clusters of closely related sequences and provides an objective system for delineating and recognizing hierarchically structured groups. In the case of the C. hybrida complex, these groups largely coincided with those established from morphology. The study adds further support to the utility of mtDNA‐based sequence profiles (the ‘DNA taxonomy’) as a rapid and objective synthesis of evolutionary diversity and as reference system for communication.
The 65 and 110 kDa SR‐related proteins of the U4/U6·U5 tri‐snRNP are essential for the assembly of mature spliceosomes

The association of the U4/U6·U5 tri‐snRNP with pre‐spliceosomes is a poorly understood step in the spliceosome assembly pathway. We have identified two human tri‐snRNP proteins (of 65 and 110 kDa) that play an essential role in this process. Characterization by cDNA cloning of the 65 and 110 kDa proteins revealed that they are likely orthologues of the yeast spliceosomal proteins Sad1p and Snu66p, respectively. Immunodepletion of either protein from the HeLa cell nuclear extracts inhibited pre‐mRNA splicing due to a block in the formation of mature spliceosomes, but had no effect on the integrity of the U4/U6·U5 tri‐snRNP. Spliceosome assembly and splicing catalysis could be restored to the respective depleted extract by the addition of recombinant 65 or 110 kDa protein. Our data demonstrate that both proteins are essential for the recruitment of the tri‐snRNP to the pre‐spliceosome but not for the maintenance of the tri‐snRNP stability. Moreover, since both proteins contain an N‐terminal RS domain, they could mediate the association of the tri‐snRNP with pre‐spliceosomes by interaction with members of the SR protein family.
Urban expansion and the environmental effects of informal settlements on the outskirts of Xalapa city, Veracruz, Mexico

This paper analyzes the dynamics of population growth and urban expansion in the city of Xalapa, Mexico. It focuses on the establishment of informal settlements, which are one of the many threats to forest and farmland conservation (although these settlements are not the only source of the problem). Spatial analysis of growth data (using Geographical Information Systems (GIS) and statistical modelling) showed that by 2007, 90 per cent of the land area in the municipality of Xalapa had already been altered by human activity. Furthermore, informal settlements occupied around 54 per cent of the urban area. The cover of cloud forest, the region’s original ecosystem that is of immense ecological importance and biological wealth, was calculated at only 7.6 per cent (9.3 square kilometres) and this is being threatened by the continued expansion of informal settlements. It appears that, at the time when these informal settlements are being established, a certain environmental logic operates, which in turn makes possible the social logic that sets off the occupation of spaces that are, in principle, not suitable for urbanization. The inadequate income of much of the population and their need for housing, as well as the absence of genuine long-term urban planning and, most importantly, the lack of legally available contiguous land for building, are encouraging the occupation of land not suitable for urban development, including sites at high risk of landslides and flooding. This is also causing natural resource and farmland degradation as well as the deterioration of living conditions within the urban boundary, problems that threaten the city’s sustainability.
Novel Strategy for Biofilm Inhibition by Using Small Molecules Targeting Molecular Chaperone DnaK

ABSTRACT Biofilms are complex communities of microorganisms that attach to surfaces and are embedded in a self-produced extracellular matrix. Since these cells acquire increased tolerance against antimicrobial agents and host immune systems, biofilm-associated infectious diseases tend to become chronic. We show here that the molecular chaperone DnaK is important for biofilm formation and that chemical inhibition of DnaK cellular functions is effective in preventing biofilm development. Genetic, microbial, and microscopic analyses revealed that deletion of the dnaK gene markedly reduced the production of the extracellular functional amyloid curli, which contributes to the robustness of Escherichia coli biofilms. We tested the ability of DnaK inhibitors myricetin (Myr), telmisartan, pancuronium bromide, and zafirlukast to prevent biofilm formation of E. coli. Only Myr, a flavonol widely distributed in plants, inhibited biofilm formation in a concentration-dependent manner (50% inhibitory concentration [IC50] = 46.2 μM); however, it did not affect growth. Transmission electron microscopy demonstrated that Myr inhibited the production of curli. Phenotypic analyses of thermosensitivity, cell division, intracellular level of RNA polymerase sigma factor RpoH, and vulnerability to vancomycin revealed that Myr altered the phenotype of E. coli wild-type cells to make them resemble those of the isogenic dnaK deletion mutant, indicating that Myr inhibits cellular functions of DnaK. These findings provide insights into the significance of DnaK in curli-dependent biofilm formation and indicate that DnaK is an ideal target for antibiofilm drugs.
Do Politically Connected Boards Affect Firm Value?

This article explores whether political connections are important in the United States. The article uses an original hand-collected data set on the political connections of board members of S&P 500 companies to sort companies into those connected to the Republican Party and those connected to the Democratic Party. The analysis shows a positive abnormal stock return following the announcement of the nomination of a politically connected individual to the board. This article also analyzes the stock-price response to the Republican win of the 2000 presidential election and finds that companies connected to the Republican Party increase in value, and companies connected to the Democratic Party decrease in value. The Author 2008. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org. , Oxford University Press.
Co-occurrence matrices for 3D shape classification

3D objects classification and retrieval are a growing research topic with many application in different areas, such as robotics, virtual/augmented reality, medicine and physics. In robotics, 3D objects can serve as robust landmarks for pose estimation and localization, so robust 3D object recognition methods are very important tools in this field. Co-occurrence matrices were used for texture classification on 2D images and 3D medical images. This work uses co-occurrence matrices for object classification, considering their 3D shape, and the method was tested on the University of Washington RGB-D dataset. This work uses only the depth information, since our main goal is to provide a 3D object recognition method, other attributes (like colors and 2D textures) can be easily integrated to this approach to further improvements in the proposed method. The obtained results are comparable to the other works on the same dataset and the source code is available online.
The Self-Pressurising Air-Q® Intubating Laryngeal Airway for Airway Maintenance during Anaesthesia in Adults: A Report of the First 100 Uses

The self-pressurising air-Q® Intubating Laryngeal Airway is a new, commercially available, supraglottic airway device that incorporates a self-regulating periglottic cuff. In this retrospective review, we describe our initial clinical experience using the device in 100 patients. The ease and number of insertion attempts, airway seal pressure, device positioning, intubation success and oropharyngeal morbidity were recorded. The air-Q Intubating Laryngeal Airway was successfully inserted in all 100 patients and functioned adequately as a primary airway in 70 of the 72 patients in which it was used for this purpose. The median (interquartile range [range]) airway seal pressure was 22 (19-29, [10-40]) cmH2O. Intubation via the air-Q Intubating Laryngeal Airway was successful in 28 of 29 (97%) patients. Eleven percent of patients complained of sore throat postoperatively before discharge. In our series, the air-Q Intubating Laryngeal Airway performed adequately as a primary airway during anaesthesia with respect to ease of insertion, adequacy of airway maintenance and as a conduit for intubation in both anticipated and unanticipated difficult airways. Although our initial experience is positive, further investigation with larger numbers of observations are needed as the upper limits of the 95% confidence intervals for device failure (the worst failure rate the clinician could expect) are still high.
Waiting for service: the effectiveness of recovery strategies

Two experiments examined the effectiveness of service recovery strategies in situations where the service firm made customers wait even though they had made a reservation. The recovery strategies ‐ apology only, assistance, compensation, assistance plus compensation ‐ which reflected industry practices, did not lead to positive future intentions towards the service firm. While assistance plus compensation was the most effective strategy, respondents still held negative future intentions towards the service firm. Other factors that had an impact included the type of hospitality service, restaurant or hotel, and the purpose for buying the service. The major implication was that current industry recovery practices were inadequate in mitigating negative intentions. When service firms break a promise, effective recovery requires considerable effort to overcome customers’ negative intentions.
An exploration of dynamic relationship between tourist arrivals, inflation, unemployment and crime rates in Malaysia

Purpose - The main purpose of this study is to examine the dynamic relationship between tourist arrivals, inflation, unemployment and crime rates in Malaysia. This study covered the annual data from 1970 to 2008. Design/methodology/approach - The multivariate Johansen-Juselius cointegration test is employed to examine the potential long-run equilibrium relationship. While the Granger causality test within the vector error-correction modelling (VECM) framework is applied to determine the causal relationship between crime rate and its determinants. Findings - The Johansen-Juselius cointegration test result reveals that the variables are cointegrated and the dynamic ordinary least squares estimator suggest that unemployment, inflation and tourist arrivals are positively related to crime rates in Malaysia. For Granger causality, in the long-run tourist arrivals, inflation and unemployment rates Granger cause crime rate in Malaysia. However, in the short run we find bilateral causality between unemployment, crime and tourist arrivals. Finally, the variance decompositions and impulse response functions analyses implied that unemployment, inflation and tourist arrivals are important in explaining the variation in crime for Malaysia. Originality/value - The estimated crime rate function for Malaysia demonstrated that promoting supply-side economy and also increases the numbers of police and patrolling duties in the potential crime areas will reduce the crime rate in Malaysia and in the same time attract more tourist arrivals to Malaysia.
Efficiency of Authoritative Disclosure Recommendations - Evidence from IFRS Transition Disclosure in Finland

Purpose - This paper aims to explore the potential for disclosure recommendations given by authoritative supervisory bodies to reduce information asymmetry between the management and shareholders. Design/methodology/approach - There is only meagre existing evidence concerning firms' responses to disclosure recommendations. This paper uses descriptive statistics and OLS regression analysis to test if firms behave more similarly to voluntary or to mandatory disclosure when they follow the Committee of European Securities Regulators disclosure recommendation for International Financial Reporting Standards transition. Second, it analyses the determinants of and incentives for recommended transition disclosure. Findings - Recommended disclosure is documented to have more mandatory characteristics than purely voluntary disclosure. Moreover, the certain disclosure incentives for managers and corporate governance factors prove to have an impact on recommended disclosure. Firm size, growth prospects, and independent board members associate positively with recommended disclosure whereas there is a negative relationship between financial leverage and recommended disclosure. Research limitations/implications - The paper does not provide evidence on the cost differences between disclosure laws and authoritative disclosure recommendations. This could be examined by future research. Practical implications - Authoritative disclosure recommendations reduce information asymmetry. In some cases they may be a faster and more cost-efficient way to achieve disclosure enhancements than regulation. Originality/value - This paper is the first to explore the efficiency of authoritative disclosure recommendations in situations where urgent disclosure improvements are needed. The results have implications for regulatory bodies evaluating different strategies to reduce asymmetric information in these situations.
Gender Differences in Labor Market Decisions in Rural Guatemala

This study analyzes male-female differences in workforce participation and self-employment in rural Guatemala. Gender differences in rural labor market outcomes are examined using the 1997 Survey of Rural Entrepreneurs and Financial Services, conducted in the rural areas of the departments of San Marcos, Quezaltenango, Huehuetenango, Alta Verapaz, Peten, and Chimiquimula. There are substantial differences in the labor force participation rates of men and women (86.5 vs 24.0 percent) and in self-employment (49.8 vs 31.9 percent). The empirical results suggest that external constraints explain almost all of the observed gender gap in employment. Gender differences in individual endowments and human capital contribute to increase the male-female self-employment gap; however, structural factors help to reduce gender differences in rural entrepreneurship. Copyright 2002 by Blackwell Publishing Ltd