Miracle-dz/UniFAR-FTUs huggingface dataset:
Lunar Cycle and Consultations for Anxiety and Depression in General Practice

The influence of the moon on patient consultations for anxiety or depression in general practice was assessed through a retrospective survey based on general practice medical records and on lunar records detailing the dates and times of different phases of the moon. Seven-hundred-eighty-two patients continuously registered in a general practice in Beckenham, South London, between 1971 and 1988 were included in analyses. No statistically significant lunar effect was found by setting the expected surge in consultations one to three days after the full moon and the period of the sine-wave curve to 30 days. Similarly, no statistically significant lunar effect was found, when the period of the sine-wave curve was allowed to vary in order to best fit the data. The moon had little influence on when individuals consulted their general practitioner with anxiety or depression.
On the Use of Electrooculogram for Efficient Human Computer Interfaces

The aim of this study is to present electrooculogram signals that can be used for human computer interface efficiently. Establishing an efficient alternative channel for communication without overt speech and hand movements is important to increase the quality of life for patients suffering from Amyotrophic Lateral Sclerosis or other illnesses that prevent correct limb and facial muscular responses. We have made several experiments to compare the P300-based BCI speller and EOG-based new system. A five-letter word can be written on average in 25 seconds and in 105 seconds with the EEG-based device. Giving message such as “clean-up” could be performed in 3 seconds with the new system. The new system is more efficient than P300-based BCI system in terms of accuracy, speed, applicability, and cost efficiency. Using EOG signals, it is possible to improve the communication abilities of those patients who can move their eyes.
Enhancing imagined contact to reduce prejudice against people with schizophrenia

Four studies investigated the effect of imagining intergroup contact on prejudice against people with schizophrenia. Experiments 1 and 2 demonstrated that a neutral imagined contact task can have negative effects, compared to a control condition, even when paired with incidental positive information (Experiment 2). Experiments 3 and 4 demonstrated, however, that an integrated positive imagined contact scenario does result in less intergroup anxiety and more positive attitudes, even toward this challenging group. Analyses of participants’ descriptions of the imagined interactions in and across the first three studies confirm that positive and high quality imagined contact is important for reducing prejudice, but failing to ensure that imagined contact is positive may have deleterious consequences. We emphasize the importance of investigating the quality of the imagined contact experience, and discuss the implications for using imagined contact as a prejudice-reducing intervention.
Layer-by-layer paper-stacking nanofibrous membranes to deliver adipose-derived stem cells for bone regeneration

Bone tissue engineering through seeding of stem cells in three-dimensional scaffolds has greatly improved bone regeneration technology, which historically has been a constant challenge. In this study, we researched the use of adipose-derived stem cell (ADSC)-laden layer-by-layer paper-stacking polycaprolactone/gelatin electrospinning nanofibrous membranes for bone regeneration. Using this novel paper-stacking method makes oxygen distribution, nutrition, and waste transportation work more efficiently. ADSCs can also secrete multiple growth factors required for osteogenesis. After the characterization of ADSC surface markers CD29, CD90, and CD49d using flow cytometry, we seeded ADSCs on the membranes and found cells differentiated, with significant expression of the osteogenic-related proteins osteopontin, osteocalcin, and osteoprotegerin. During 4 weeks in vitro, the ADSCs cultured on the paper-stacking membranes in the osteogenic medium exhibited the highest osteogenic-related gene expressions. In vivo, the paper-stacking scaffolds were implanted into the rat calvarial defects (5 mm diameter, one defect per parietal bone) for 12 weeks. Investigating with microcomputer tomography, the ADSC-laden paper-stacking membranes showed the most significant bone reconstruction, and from a morphological perspective, this group occupied 90% of the surface area of the defect, produced the highest bone regeneration volume, and showed the highest bone mineral density of 823.06 mg/cm3. From hematoxylin and eosin and Masson staining, the new bone tissue was most evident in the ADSC-laden scaffold group. Using quantitative polymerase chain reaction analysis from collected tissues, we found that the ADSC-laden paper-stacking membrane group presented the highest osteogenic-related gene expressions of osteocalcin, osteopontin, osteoprotegerin, bone sialoprotein, runt-related transcription factor 2, and osterix (two to three times higher than the control group, and 1.5 times higher than the paper-stacking membrane group in all the genes). It is proposed that ADSC-laden layer-by-layer paper-stacking scaffolds could be used as a way of promoting bone defect treatment.
Anatomy and histochemistry of spread‐wing posture in birds. 3. Immunohistochemistry of flight muscles and the “shoulder lock” in albatrosses

As a postural behavior, gliding and soaring flight in birds requires less energy than flapping flight. Slow tonic and slow twitch muscle fibers are specialized for sustained contraction with high fatigue resistance and are typically found in muscles associated with posture. Albatrosses are the elite of avian gliders; as such, we wanted to learn how their musculoskeletal system enables them to maintain spread‐wing posture for prolonged gliding bouts. We used dissection and immunohistochemistry to evaluate muscle function for gliding flight in Laysan and Black‐footed Albatrosses. Albatrosses possess a locking mechanism at the shoulder composed of a tendinous sheet that extends from origin to insertion throughout the length of the deep layer of the pectoralis muscle. This fascial “strut” passively maintains horizontal wing orientation during gliding and soaring flight. A number of muscles, which likely facilitate gliding posture, are composed exclusively of slow fibers. These include Mm. coracobrachialis cranialis, extensor metacarpi radialis dorsalis, and deep pectoralis. In addition, a number of other muscles, including triceps scapularis, triceps humeralis, supracoracoideus, and extensor metacarpi radialis ventralis, were found to have populations of slow fibers. We believe that this extensive suite of uniformly slow muscles is associated with sustained gliding and is unique to birds that glide and soar for extended periods. These findings suggest that albatrosses utilize a combination of slow muscle fibers and a rigid limiting tendon for maintaining a prolonged, gliding posture. J. Morphol. 263:12–29, 2005. © 2004 Wiley‐Liss, Inc.
Mental Health of Undocumented Mexican Immigrants: A Review of the Literature

The Latino population in the United States, the majority of whom are Mexican, is one of the fastest growing. Similarly, the number of undocumented Mexican immigrants (UMIs) continues to swell. However, little is known about UMIs living in the United States, and much less is known about their mental health status. This interdisciplinary review of the literature aims to outline the current state of knowledge regarding the mental health of UMIs in the United States. Themes isolated from the literature include failure to succeed in the country of origin; dangerous border crossings; limited resources; restricted mobility; marginalization/isolation; blame/stigmatization and guilt/shame; vulnerability/exploitability; fear/fear-based behaviors; and stress, depression, and health implications.
Chlorite dismutases – a heme enzyme family for use in bioremediation and generation of molecular oxygen

Chlorite is a serious environmental concern, as rising concentrations of this harmful anthropogenic compound have been detected in groundwater, drinking water, and soil. Chlorite dismutases (Clds) are therefore important molecules in bioremediation as Clds catalyze the degradation of chlorite to chloride and molecular oxygen. Clds are heme b‐containing oxidoreductases present in numerous bacterial and archaeal phyla. This review presents the phylogeny of functional Clds and Cld‐like proteins, and demonstrates the close relationship of this novel enzyme family to the recently discovered dye‐decolorizing peroxidases. The available X‐ray structures, biophysical and enzymatic properties, as well as a proposed reaction mechanism, are presented and critically discussed. Open questions about structure‐function relationships are addressed, including the nature of the catalytically relevant redox and reaction intermediates and the mechanism of inactivation of Clds during turnover. Based on analysis of currently available data, chlorite dismutase from “Candidatus Nitrospira defluvii” is suggested as a model Cld for future application in biotechnology and bioremediation. Additionally, Clds can be used in various applications as local generators of molecular oxygen, a reactivity already exploited by microbes that must perform aerobic metabolic pathways in the absence of molecular oxygen. For biotechnologists in the field of chemical engineering and bioremediation, this review provides the biochemical and biophysical background of the Cld enzyme family as well as critically assesses Cld's technological potential.
Pathophysiology of the Rhesus Macaque Model for Inhalational Brucellosis

ABSTRACT The objective of this study was to characterize the rhesus macaque (RM) as a model for inhalational brucellosis in support of the U.S. Food and Drug Administration's (FDA) Animal Rule. The pathophysiology of chronic Brucella melitensis aerosol infection was monitored in two phases that each occurred over an 8-week time period; dose escalation (8 RMs; targeted doses of 5.0E+03, 5.0E+04, or 5.0E+05 CFU/animal or the unchallenged control) and natural history (12 RMs; targeted dose of 2.50E+05 CFU/animal or the unchallenged control). RMs given an aerosol challenge with B. melitensis developed undulating fevers (6/6 phase I; 8/9 phase II), positive enriched blood cultures (5/10; phase II), and bacterial burdens in tissues starting 14 to 21 days postchallenge (6/6 phase I; 10/10 phase II). In addition, 80% (8/10; phase II) of infected RMs seroconverted 14 to 21 days postchallenge. RMs developed elevations in certain liver enzymes and had an increased inflammatory response by 3 weeks postchallenge as shown by increases in C-reactive protein (6/8) and neopterin (4/8), which correlated with the onset of a fever. As early as 14 days postchallenge, positive liver biopsy specimens were detected (2/8), and ultrasound imaging showed the development of splenomegaly. Finally, histopathologic examination found lesions attributed to Brucella infection in the liver, kidney, lung, and/or spleen of all animals. The disease progression observed with the RMs in this study is analogous to human brucellosis pathophysiology. Thus, the results from this study support the use of the RM as an animal model for inhalational brucellosis to evaluate the efficacy of novel vaccines and therapeutics against B. melitensis.
Ultrafilters: Some old and some new results

BY W. W. COMFORT I am grateful to Peter Freyd for his generous introductory comments, and I am grateful also to the [Selection] Committee for extending the invitation to speak to you. Last month a colleague with whom I attempted to discuss today's remarks suggested drily that as half of the team responsible for [CN2] I have probably already said more than enough about ultrafllters, and that if I insist on pursuing the matter further today I could do so most gracefully and efficiently simply by offering a complimentary copy of [CN2] to each of you. Eschewing that advice I shall in the hour allotted to me attempt to achieve the following three goals. (A) To acquaint you with what I think are some of the most basic, fundamental facts about ultrafllters on a discrete topological space; this material is sufficiently simple and elegant that it can be absorbed comfortably into a first-year graduate course in general topology. (B) To give some partial results, less definitive and less conclusive than the optimal theorems available, concerning the existence of particular ultrafllters with special properties; I hope that the results chosen in this connection have the complementary virtues that they are sufficiently powerful to handle most of the situations treated by the more powerful results which we shall ignore, and that their proofs are significantly simpler than those of the more general results. (C) To record some results about ultrafllters which came to my attention after the publication of [CN2]; I have chosen today to emphasize three relatively new results which are not formally concerned with ultrafllters and which indeed make no mention of ultrafllters in their statements, but which nevertheless have been given proofs in which ultrafllters play an important catalytic role. My hope is that (even) those of you not professionally inclined toward topology or set theory will find something potentially useful, or amusing, among the basic results given in (A). The theorems selected for inclusion in (B) are given not only because of the intrinsic beauty and elegance of their proofs, but also because they serve to indicate the principal sorts of questions
Psychological assessment in post-apartheid South Africa: the way forward

In 2014, South Africa is into its 20th year since the 1994 elections which ushered in a democratic government and marked the official end of apartheid. The discipline of Psychology has in this time attained many milestones, several of which relate to the sub-discipline of psychological assessment. Prior to, during, and post-apartheid, psychological assessment featured as one of the most contentious areas in the history of the country, as well as the history of Psychology. In this article, we provide some critical insights into those aspects in the history of psychological assessment in South Africa that have led it to be the provocative field it is today. We also identify the positive contributions of psychological assessment that have facilitated South Africa’s movement towards a more just and equitable society. The article concludes with suggestions for the future development of psychological assessment and how it can serve to enhance the discipline of Psychology and the wellbeing of South Africans.
An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology

Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including development, reproduction, longevity and several specific stress responses. Our systematic studies identify an ILP-based combinatorial code for these phenotypes characterized by substantial functional specificity and diversity rather than global redundancy. Notably, we show that ILPs regulate each other transcriptionally, uncovering an ILP-to-ILP regulatory network that underlies the combinatorial phenotypic coding by the ILP family. Extensive analyses of genetic interactions among ILPs reveal how their signals are integrated. A combined analysis of these functional and regulatory ILP interactions identifies local genetic circuits that act in parallel and interact by crosstalk, feedback and compensation. This organization provides emergent mechanisms for phenotypic specificity and graded regulation for the combinatorial phenotypic coding we observe. Our findings also provide insights into how large hormonal networks regulate diverse traits.
Combination of Chinese Herbal Medicines and Conventional Treatment versus Conventional Treatment Alone in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention (5C Trial): An Open-Label Randomized Controlled, Multicenter Study

Aims. To evaluate the efficacy of Chinese herbal medicines (CHMs) plus conventional treatment in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods and Results. Participants (n = 808) with ACS who underwent PCI from thirteen hospitals of mainland China were randomized into two groups: CHMs plus conventional treatment group (treatment group) or conventional treatment alone group (control group). All participants received conventional treatment, and participants in treatment group additionally received CHMs for six months. The primary endpoint was the composite of cardiac death, nonfatal recurrent MI, and ischemia-driven revascularization. Secondary endpoint was the composite of readmission for ACS, stroke, or congestive heart failure. The safety endpoint involved occurrence of major bleeding events. The incidence of primary endpoint was 2.7% in treatment group versus 6.2% in control group (HR, 0.43; 95% CI, 0.21 to 0.87; P = 0.015). The incidence of secondary endpoint was 3.5% in treatment group versus 8.7% in control group (HR, 0.39; 95% CI, 0.21 to 0.72; P = 0.002). No major bleeding events were observed in any participant. Conclusion. Treatment with CHMs plus conventional treatment further reduced the occurrence of cardiovascular events in patients with ACS after PCI without increasing risk of major bleeding.
Molecular Evolution of Slow and Quick Anion Channels (SLACs and QUACs/ALMTs)

Electrophysiological analyses conducted about 25 years ago detected two types of anion channels in the plasma membrane of guard cells. One type of channel responds slowly to changes in membrane voltage while the other responds quickly. Consequently, they were named SLAC, for SLow Anion Channel, and QUAC, for QUick Anion Channel. Recently, genes SLAC1 and QUAC1/ALMT12, underlying the two different anion current components, could be identified in the model plant Arabidopsis thaliana. Expression of the gene products in Xenopus oocytes confirmed the quick and slow current kinetics. In this study we provide an overview on our current knowledge on slow and quick anion channels in plants and analyze the molecular evolution of ALMT/QUAC-like and SLAC-like channels. We discovered fingerprints that allow screening databases for these channel types and were able to identify 192 (177 non-redundant) SLAC-like and 422 (402 non-redundant) ALMT/QUAC-like proteins in the fully sequenced genomes of 32 plant species. Phylogenetic analyses provided new insights into the molecular evolution of these channel types. We also combined sequence alignment and clustering with predictions of protein features, leading to the identification of known conserved phosphorylation sites in SLAC1-like channels along with potential sites that have not been yet experimentally confirmed. Using a similar strategy to analyze the hydropathicity of ALMT/QUAC-like channels, we propose a modified topology with additional transmembrane regions that integrates structure and function of these membrane proteins. Our results suggest that cross-referencing phylogenetic analyses with position-specific protein properties and functional data could be a very powerful tool for genome research approaches in general.
Goal driven requirements engineering: Evaluation of current methods.

In the field of Requirements Engineering, goal modelling approaches have received much attention in recent years by researchers and practitioners alike. In this paper we identify the uses of these approaches in different contexts of requirements analysis phases. We examine goal modelling in terms of five methodological orientations and define a framework for their analysis. Using this framework we evaluate goal modelling in a systematic and consistent manner and reflect on current investigations and open issues that provide a foundation for further research in this important area of Requirements Engineering methodology.
Journal of Economic Behavior & Organization a Simplified Stock-flow Consistent Dynamic Model of the Systemic Financial Fragility in the 'new Capitalism'

In the last few years, many financial analysts and heterodox economists (but even some 'dissenters' among orthodox economists) have referred to the contribution of Hyman P. Minsky as a fundamental reading for understanding the current crisis. However, it is well known that the traditional formulation of Minsky's 'financial instability hypothesis' raises a number of theoretical issues. Furthermore, Minsky's analysis of capitalism must be updated on the basis of the deep changes which, during the last three decades, have concerned the world economy. In order to address these theoretical and empirical issues, the paper, first, introduces the reader to the 'mechanics' of the financial instability theory, according to the formulation of the traditional Minskian literature (Section 2). Second, it shows that Min-sky's theory, in this formulation, cannot be regarded as a general theory of the business cycle (Section 3). Third, the paper attempts to supply a consistent, although simplified, updating of Minsky's theory by cross-breeding it with inputs coming from the 'New Cam-bridge' theories and the current 'formal Minskian literature'. The aim of this is to analyse the impact of both capital-asset inflation and consumer credit on the financial 'soundness' of the business sector (Sections 4–7). Some concluding remarks are provided in the last part of the paper (Section 8).
Genes Making One Feel Blue in the Flow of Daily Life: A Momentary Assessment Study of Gene-Stress Interaction

Objective: Individual differences in stress reactivity constitute a crucially important mechanism of risk for depression. Because stress can be conceptualized as the continuous occurrence of minor daily hassles, this study focused on emotional reactivity to stress in the flow of daily life and examined to what degree individual differences in emotional reactivity could be explained by genetic and/or environmental factors. Methods: Two hundred seventy-five female twin pairs (170 monozygotic and 105 dizygotic) participated in this experience sampling study (ESM). ESM is a validated structured diary technique assessing stressors and mood in daily life. Individual emotional stress reactivity was conceptualized as changes in negative affect in relation to appraised subjective stress in relation to daily events. Structural equation modeling was used to fit univariate models. The best fitting model was chosen based on likelihood and parsimony. Results: Genetic factors (explaining 12% individual differences) and individual-specific environmental factors (explaining 88%) influenced daily life stress reactivity. Conclusion: The demonstration of a small genetic influence on the dynamic relationship between minor stress and affective response in the flow of daily life sheds light on the gene-environment interactions that contribute to the risk of developing stress related disorders such as depression. ESM = experience sampling method; PA = positive affect; NA = negative affect; MZ = monozygotic; DZ = dizygotic; RMSEA = root mean squared error approximation; SERT = serotonin transporter gene.