Miracle-dz/UniFAR-FTUs huggingface dataset:
PRAC2: A new gene expressed in human prostate and prostate cancer

The database of human Expressed Sequence Tags was previously used to identify PRAC (Prostate 47:125–131, 2001), a novel gene specifically expressed in human prostate, prostate cancer, rectum, and distal colon. In this report, we have identified PRAC2, another gene with a similar expression pattern that is located adjacent to the original PRAC gene on chromosome 17q21.3.
A Clinical and Risk Profile of Forensic Psychiatric Patients: Treatment Team STARTs in a Canadian Service

Current best practice guidelines recommend clinicians consider clients’ strengths as well as their deficits (APA, 2006; Department of Health, 2007). The Short-Term Assessment of Risk and Treatability (START) is one of the few structured professional judgment (SPJ) measures that facilitate this balanced approach to assessment and treatment planning. START is a concise clinical guide for the assessment and management of seven short-term (i.e., weeks to months) risk estimates (violence, self-harm, suicide, substance abuse, unauthorized leave, self-neglect, and being victimized) that occur at elevated rates in populations of individuals living with mental illness and personality disorders. Research on START has focused to some extent on assessments completed by research assistants. This study examined the implementation of START into a large forensic psychiatric service and reports on the psychometric properties of the measure when completed by multidisciplinary treatment teams. All START forms completed over a one-year period were evaluated (N= 1057). Results indicate good structural reliability and excellent dispersion across the items, scales, and risk estimates. Few differences were noted by patient gender. Signature risk signs were much more common than expected (27%). It is notable that few patients were determined to be high risk on any of the seven risk estimates, with the exception of substance abuse. Overall, the results provide preliminary evidence for the success of the implementation and the value of the START for informing needs and treatment planning in forensic services.
Clostridial Bloodstream Infections

In a ten-year review at a large community teaching hospital clostridia accounted for less than 1% of all positive bloodstream isolates (26 episodes in 25 patients). All but one of the isolates were clinically significant. Twenty-two patients (88%) had a serious underlying medical condition, and 17 of the episodes (65%) were associated with a bowel source; twelve patients (48%) died of their infection. Clostridial bloodstream infections are particularly clinically significant in patients with serious underlying disease.
Race, Neighbourhood Context and Perceptions of Injustice by the Police in Cincinnati

Research has long identified racial differences in perceptions of criminal injustice. Given that race is confounded with neighbourhood context, it remains unclear the extent to which individual or neighbourhood attributes explain racial differences in these perceptions. This paper advances research on racial differences in perceptions of unjust police practices in the US by relying on a survey of 3000 residents in 53 Cincinnati neighbourhoods. A propensity score weighting approach is used to identify a model by which Whites and Blacks living in similar neighbourhood environments can be compared with each other. The results demonstrate that race remains a significant predictor of perceptions of unjust police practices, even after taking into account the ecological structuring of neighbourhoods and their perceived environmental context. These findings suggest that racial consciousness with regard to perceived injustices by the police is not purely a condition of personal or structural disadvantage. The implications of these findings for police reform efforts to mend minority relations in urban cities are discussed.
Primitive Defenses in the Language of the Psychopath: Considerations for Forensic Practice

ABSTRACT The PCL-R is the primary means of assessing psychopathy in research and forensic practice. However, recent research suggests that supplemental measures of defensive process used in conjunction with the PCL-R may better capture the psychopath's internal core. Borderline personality organization and the relationship between defensive process and cognitive style are inextricably linked to psychopath's ability to feel. The use of primitive defenses guides the psychopath's interpersonal style and mediates emotional experience. The relationship between unconscious defensive process and conscious cognitive style is a distinguishing feature of psychopathy within which the unique emotional (and emotionless) experiences of the psychopath can be more fully explored and understood. This paper reviews the literature on the assessment of borderline personality organization in psychopaths offering illustration of expression of primitive defenses in the language of the psychopath. The ways in which psychopaths' verbal and interpersonal expressions of defensive process can be utilized in criminology, criminal justice, and forensic practice are discussed.
Classification, measurement and the ontology of intellectual capital entities

Purpose – The paper discusses the role of measurement and classification in intellectual capital research. Its purpose is to develop an alternative role for measure. The aim is to explore how measurement may be important even if it does not pretend to accurately represent and underlying reality.Design/methodology/approach – The paper is an essay on the difficulties of measuring intellectual capital. It is a conceptual, analytical paper which proposes a new approach to analyzing the roles and effects of measurement in the area of intellectual capital.Findings – The analysis suggests that measurement of intellectual capital is difficult because it is not possible to copy its properties in a number; yet it is necessary because it allows intervention to happen since it develops a wholly new set of dimensions to manage. This dual conclusion both problematic because the search for a definitive measure of the size, value and effects of intellectual capital is impossible, yet it is also comforting because measure.
Activation of Natural Killer Cells during Microbial Infections

Natural killer (NK) cells are large granular lymphocytes that express a diverse array of germline encoded inhibitory and activating receptors for MHC Class I and Class I-like molecules, classical co-stimulatory ligands, and cytokines. The ability of NK cells to be very rapidly activated by inflammatory cytokines, to secrete effector cytokines, and to kill infected or stressed host cells, suggests that they may be among the very early responders during infection. Recent studies have also identified a small number of pathogen-derived ligands that can bind to NK cell surface receptors and directly induce their activation. Here we review recent studies that have begun to elucidate the various pathways by which viral, bacterial, and parasite pathogens activate NK cells. We also consider two emerging themes of NK cell–pathogen interactions, namely their contribution to adaptive immune responses and their potential to take on regulatory and immunomodulatory functions.
Modulation of Kv3 Subfamily Potassium Currents by the Sea Anemone Toxin BDS: Significance for CNS and Biophysical Studies

Kv3 potassium channels, with their ultra-rapid gating and high activation threshold, are essential for high-frequency firing in many CNS neurons. Significantly, the Kv3.4 subunit has been implicated in the major CNS disorders Parkinson's and Alzheimer's diseases, and it is claimed that selectively targeting this subunit will have therapeutic utility. Previous work suggested that BDS toxins (“blood depressing substance,” from the sea anemone Anemonia sulcata) were specific blockers for rapidly inactivating Kv3.4 channels, and consequently these toxins are increasingly used as diagnostic agents for Kv3.4 subunits in central neurons. However, precisely how selective are these toxins for this important CNS protein? We show that BDS is not selective for Kv3.4 but markedly inhibits current through Kv3.1 and Kv3.2 channels. Inhibition comes about not by “pore block” but by striking modification of Kv3 gating kinetics and voltage dependence. Activation and inactivation kinetics are slowed by BDS-I and BDS-II, and V1/2 for activation is shifted to more positive voltages. Alanine substitution mutagenesis around the S3b and S4 segments of Kv3.2 reveals that BDS acts via voltage-sensing domains, and, consistent with this, ON gating currents from nonconducting Kv3.2 are markedly inhibited. The altered kinetics and gating properties, combined with lack of subunit selectivity with Kv3 subunits, seriously affects the usefulness of BDS toxins in CNS studies. Furthermore, our results do not easily fit with the voltage sensor “paddle” structure proposed recently for Kv channels. Our data will be informative for experiments designed to dissect out the roles of Kv3 subunits in CNS function and dysfunction.
Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review.

OBJECTIVES to determine the effect of drugs with anti-cholinergic properties on relevant health outcomes. DESIGN electronic published and unpublished literature/trial registries were systematically reviewed. Studies evaluating medications with anti-cholinergic activity on cognitive function, delirium, physical function or mortality were eligible. RESULTS forty-six studies including 60,944 participants were included. Seventy-seven percent of included studies evaluating cognitive function (n = 33) reported a significant decline in cognitive ability with increasing anti-cholinergic load (P < 0.05). Four of five included studies reported no association with delirium and increasing anti-cholinergic drug load (P > 0.05). Five of the eight included studies reported a decline in physical function in users of anti-cholinergics (P < 0.05). Three of nine studies evaluating mortality reported that the use of drugs with anti-cholinergic properties was associated with a trend towards increased mortality, but this was not statistically significant. The methodological quality of the evidence-base ranged from poor to very good. CONCLUSION medicines with anti-cholinergic properties have a significant adverse effect on cognitive and physical function, but limited evidence exists for delirium or mortality outcomes.
The Effects of Unit Self‐Management on Hospital Nurses' Work Process, Work Satisfaction, and Retention

A number of innovative practice models have been introduced in an effort to resolve the hospital nursing shortage and improve the working conditions and retention of registered nurses. This study examines the effects of a unit-level self-management model (including salaried compensation and gainsharing) in a number of clinical areas at The Johns Hopkins Hospital in Baltimore, Maryland. In comparisons of nurses on self-managed and traditional nursing units, outcomes examined were nurses' perceptions of their work process, nurses' work satisfaction levels, and nurses' retention. The self-management model is found to increase work satisfaction through effects on two work process variables: coordination of care and effective team performance. The model is also associated with higher retention. Nurses on self-managed units work longer hours but earn increased pay; the effects of hours and pay on work satisfaction and retention are discussed.
[Anatomic and topographic models of the cerebral areas that activates during the linguistic functions].

AIM A brief revision was performed in order to develop a topographic model of cerebral activation during silent reading, syllable's repetition and emotional prosody, based in recent neuroimaging studies. DEVELOPMENT It has been reported that the words are analyzed in both occipital hemispheres during silent reading, after they are 'written' in the right temporal cortex while the integration of the semantic and phonologic processes are integrated on different left temporal areas and also in the left frontal lower part. The understanding is achieved in the left-middle temporal cortex. In the other hand, activation during articulatory movements is carried out in the left supratemporal gyrus and the left motor and premotor cortex, the left putamen and part of both hemispheres of the cerebellum. Finally, recognition of the emotional prosody occurs in three stages: obtaining of the acoustic information in some areas of the right temporal lobe, representation of acoustic sequences in the right posterio-superior temporal area, and an evaluation of the emotional prosody in the lower frontal bilateral cortex, with the involvement of the basal ganglia in the emotional expression. CONCLUSIONS The location and synchrony of the areas that activate during the language processing is lateralized toward the left hemisphere and it involves cortical and subcortical areas, except for the emotional prosody. The understanding of the language processes will open the field for to take advantage of the plastic mechanisms for the speech therapy and rehabilitation.
COMPARISON OF THE EFFECTS OF LEXICAL AND ONTOLOGICAL INFORMATION ON TEXT CATEGORIZATION by CESAR KOIRALA

ON TEXT CATEGORIZATION by CESAR KOIRALA (Under the Direction of Khaled Rasheed) ABSTRACT This thesis compares the effectiveness of using lexical and ontological information for text categorization. Lexical information has been induced using stemmed features. Ontological information, on the other hand, has been induced in the form of WordNet hypernyms. Text representations based on stemming and WordNet hypernyms were evaluated using four different machine learning algorithms on two datasets. The research reports average F1 measures as the results. The results show that, for the larger dataset, stemming-based text representation gives better performance than hypernym-based text representation even though the later uses a novel hypernym formation approach. However, for the smaller data set with relatively lower feature overlap, hypernym-based text representations produce results that are comparable to the stemming-based text representation. The results also indicate that combining stemming-based representation and hypernym-based representation produces an improvement in the performance for the smaller dataset.
Knowledge, Commitment, and Attitudes of Home Economics Faculty Toward Computers

This research assessed attitudes, knowledge, and commitment of home econom ics faculty toward computers as educational tools. It utilized a national survey (n = 719) of faculty from member institutions of the Association of Administrators of Home Economics in State Universities and Land Grant Colleges and the National Council of Administrators of Home Economics. Data analyses showed no signif icant differences in attitudes attributable to gender, computer programming ex perience, computer ownership, age, number of years teaching, or number of computer classes taken. No significant differences in computer knowledge could be attributed to gender. The number of years teaching and computer experience had a positive effect on both computer knowledge and commitment scores. As attitudes were positive, but not strongly positive, an overall goal for computer instruction should include the affective domain. Learning experience should be designed for groups at various levels of computer competence. Respondents repeatedly cited lack of appropriate software as a deterrent to classroom use.
The Syntax of Nominal Arguments in Early Child English

This article presents an analysis of the syntax of nominal arguments in the early patterned speech of young children natively acquiring English. The overall hypothesis is that the earliest syntactic structures they produce are purely thematic and lexical. Consequently, the earliest nominals produced by young children are thematic in nature, lacking nonthematic constituents like expletive pronouns and nonthematic prepositions. This assumption accounts for the nonacquisition of referential and possessive determiners. I further maintain that early child nominals are purely lexical projections of nouns into noun phrases and thus lack adult functional projections of determiners into determiner phrases (DPs). Child nominals also lack the adult case and binding properties of DPs and so are caseless, unindexed noun phrases. Taken together, these assumptions provide a principled account of the absence of nominal movement chains in early child English. I examine several possible explanations for the lexical-themati.
Happiness among Portuguese and Indian adolescents from immigrant families in Portugal

This study examined the level of happiness among adolescents whose families are from India, in comparison to Portuguese adolescents who did not go through an acculturation process. It also examined if happiness can be predicted by demographic and mental health factors. There were 542 adolescent participants. Of these, 366 were Portuguese and 175 belonged to families coming from India. The participants completed the Oxford Happiness Inventory, the Revised UCLA Loneliness Scale, the Satisfaction With Life Scale and a short biographical form. The hypotheses were partially supported. Indian adolescents from an immigrant background living in Portugal showed more happiness than Portuguese adolescents. Psychological constructs (self-esteem, satisfaction with life and loneliness) were more important in the prediction of happiness than the sociodemographic variables. With immigrant youth showing good psychological adaptation, our study lends further support to several studies from the USA suggesting that immigrant children generally adapt well and in some cases better than their national peers.
Velocity-based reinitialisation approach in Particle Swarm Optimisation for feature selection

Particle Swarm Optimisation (PSO) algorithm is known to be better than Genetic Algorithm (GA) as fewer operators are needed in its algorithm. However, it still has some weaknesses such as immature convergence; a condition whereby PSO tends to get trapped in a local optimum. This condition prevents them from being converged towards a better position. Various techniques have been proposed to tackle this problem by many means. This paper attempts to integrate several velocity-based reinitialisation (VBR) approaches in PSO for solving feature selection problem. Five benchmark datasets of various features dimension were used to implement the approaches. The results were analysed based on classifier performance and the selected number of features. The findings show that the proposed VBR is generally significantly better than the existing VBR approaches.
Students’ Social Positioning in the Language Classroom: Implications for Interaction

This paper outlines some findings of a three-month investigation into the effects of students’ interpersonal relationships on communication in two EFL classrooms in a Japanese university. Data was collected to identify and describe the various social subgroups that existed within the classes, and samples of classroom discourse were then analysed to investigate how students’ social positioning in the classroom affected the observed interaction. The analysis suggests that the relationships that students develop in the classroom do have implications for interaction, and that conducting research into those relationships could have a positive impact on teachers management of classroom interaction.
Harnessing the immune system for cancer therapy

Purpose of review Over the last 18 months, substantial progress has been made in demonstrating the clinical efficacy of harnessing the immune system to treat a variety of both solid and hematologic malignancies. This review summarizes and evaluates these seminal studies. Recent findings The two treatment modalities most responsible for the success of immune based therapies in cancer are adoptive T-cell therapy and immunoregulatory antibodies. Specifically, immunotherapy is generating responses in malignancies that would otherwise have no traditional curative options such as CD19-targeted chimeric antigen receptors to treat relapsed/refractory acute lymphocytic leukemia and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and PD-1 blockade alone or in combination to treat metastatic melanoma and other solid tumors. Summary We are at a turning point for the field of cancer immunotherapy. The scientific community is now, after decades of research, proving that these treatments have great promise for patients. Ongoing preclinical research and clinical trials over the next few years will determine the extent of impact cancer immunotherapy will have on the treatment of the general population.
Religious and Spiritual Values Transactions: A Constant-Comparison Analysis of Grandmothers and Adult-Granddaughters

Religious and spiritual development continues throughout the lifespan, with life transitions, trajectories, and stages affecting that development. One important catalyst for these changes is family relationships. This article examines transactions between grandmothers and adult-granddaughters that influence both parties' spiritual and religious values. Semi-structured interviews were conducted with eight grandmother/adult-granddaughter dyads. Data indicate that grandmothers and adult-granddaughters learn one another's values through multiple transactions including role-modeling, indirect communication, and “just knowing. ” Yet, co-learning did not occur in every situation within these dynamic transactions. Implications are given for family interventionists on understanding and developing grandmother/granddaughter relationships and spiritual growth.
Protective Effects of Intralipid and Caffeic Acid Phenyl Esther (CAPE) on Neurotoxicity Induced by Ethanol in Rats.

AIM Ethanol causes oxidative degradation of the mitochondrial genome in the brain. This effect could contribute to the development of brain injury in some alcoholic patients. We investigated the protective effect of caffeic acid phenyl esther (CAPE) and intralipid (IL) on oxidative stress and neurotoxicity induced by ethanol intake. MATERIAL AND METHODS The forty-eight rats were randomly divided into seven groups. Ethanol was administered for acute toxicity. IL and CAPE were administered immediately after ethanol intake. Total oxidant status (TOS), total antioxidant status (TAS), and oxidative status index (OSi) were evaluated and histologic examination of cerebellum and brain tissue with Hematoxylin-Eosin and immuno-histochemical dyes was performed. RESULTS In the ethanol group, TAS levels were significantly lower than the other groups and this finding indicates that the toxic effect of ethanol reduces antioxidant levels. In the ethanol group, TOS levels were significantly higher than the other groups. These results showed that ethanol induced oxidative stress. IL treatment increased TAS levels, and CAPE decreased TOS levels against ethanol toxicity. There was correlation between TAS and TOS levels. Also, histopathologic results confirmed these biochemical results. CONCLUSION CAPE and IL treatment could be effective course of therapy to enhance therapeutic efficacy and may provide a promising approach for the treatment of neurotoxicity and oxidative stress induced by ethanol in clinic.