Miracle-dz/UniFAR-FTUs huggingface dataset:
Will vaccination against human papillomavirus prevent eye disease? A review of the evidence

The role of human papillomavirus (HPV) infection in eye disease is controversial. However, a recent case illustrates the possible role of HPV in conjunctival squamous carcinoma and the potentially devastating effects of this disease. The development of two vaccines to prevent infection with HPV types most commonly associated with anogenital cancers has led to debate about the pros and cons of a national immunisation programme to prevent cervical cancer. The introduction of such a vaccination programme may have an additional beneficial effect on the occurrence of some head and neck, including ocular, cancers. This review discusses the nature of papillomaviruses, mechanisms of infection and carcinogenesis, the possible role of HPV in eye disease, and finally the likely impact of the new prophylactic vaccines.
Asset Pricing in a Monetary Economy with Heterogeneous Beliefs

In this paper, we shed new light on the role of monetary policy in asset pricing by examining the case in which investors have heterogeneous expectations about future monetary policy. This case is realistic because central banks are typically less than perfectly open about their intentions. Accordingly, surveys of economists reveal that they frequently disagree in their expectations. Under heterogeneity in beliefs, investors place speculative bets against each other on the evolution of the money supply, and as a result the sharing of wealth in the economy evolves stochastically. Employing a continuous-time equilibrium model, we show that these fluctuations majorly affect the prices of all assets, as well as inflation. Our model could help explain some empirical puzzles. In particular, we find that the volatility of bond yields and stock market volatility could be significantly increased by the heterogeneity in beliefs, a conclusion supported by our empirical analyses. This paper was accepted by Wei Xiong, finance.
Recurrence of hepatitis C after liver transplantation

Recurrence of hepatitis C virus (HCV) infection following liver transplantation is a major source of morbidity and mortality. The natural history of hepatitis C in the transplant setting is shortened. Overall, one third of HCV-infected recipients have developed allograft cirrhosis due to HCV recurrence by the 5th-7th year post-transplantation. The most significant variables which determine disease progression are the use of organs from old donors, the use of an inadequate immunosuppression (too low, inducing treatment rejection episodes, too potent or too rapidly changing), and the presence of comorbid conditions that also impact the quality of the graft (biliary complications, metabolic syndrome). The only factor consistently shown to modify the natural history of recurrent disease is antiviral therapy. A sustained viral response, achieved by one third of those treated with dual therapy, is associated with improved histology, reduced liver-related complications and increased survival. Variables associated with enhanced viral response with dual therapy include an adequate genetic background (IL28B C/C of both donor and recipient), good treatment adherence (full doses of ribavirin, treatment duration), lack of graft cirrhosis at baseline, and viral genotype non-1. Data with triple therapy are encouraging. Response rates of about 60% at end-of-therapy have been described. Drug-drug interactions with calcineurin inhibitors are present but easily manageable with strict trough levels monitoring. Side effects are frequent and severe, particularly anemia, infections and acute renal insufficiency. In the future new oral antivirals will likely prevent viral reinfection. In this review, we will cover the most significant but also controversial aspects regarding recurrent HCV infection, including the natural history, retransplantation, antiviral therapy, and outcome in HIV-HCV patients.
KCNQ1 mutations associated with Jervell and Lange–Nielsen syndrome and autosomal recessive Romano–Ward syndrome in India—expanding the spectrum of long QT syndrome type 1

Long QT syndrome type 1 (LQT1) is the most common type of all Long QT syndromes (LQTS) and occurs due to mutations in KCNQ1. Biallelic mutations with deafness is called Jervell and Lange–Nielsen syndrome (JLNS) and without deafness is autosomal recessive Romano–Ward syndrome (AR RWS). In this prospective study, we report biallelic mutations in KCNQ1 in Indian patients with LQT1 syndrome. Forty patients with a clinical diagnosis of LQT1 syndrome were referred for molecular testing. Of these, 18 were excluded from the analysis as they did not fulfill the inclusion criteria of broad T wave ECG pattern of the study. Direct sequencing of KCNQ1 was performed in 22 unrelated probands, parents and at‐risk family members. Mutations were identified in 17 patients, of which seven had heterozygous mutations and were excluded in this analysis. Biallelic mutations were identified in 10 patients. Five of 10 patients did not have deafness and were categorized as AR RWS, the rest being JLNS. Eight mutations identified in this study have not been reported in the literature and predicted to be pathogenic by in silico analysis. We hypothesize that the homozygous biallelic mutations identified in 67% of families was due to endogamous marriages in the absence of consanguinity. This study presents biallelic gene mutations in KCNQ1 in Asian Indian patients with AR JLNS and RWS. It adds to the scant worldwide literature of mutation studies in AR RWS. © 2016 Wiley Periodicals, Inc.
The State and the Parties

This article focuses on the relationship between political parties and the state. We propose an analytical framework distinguishing between three different dimensions of the party-state linkage: the dependence of parties on the state, the management of parties by the state and the control of the state by parties. We provide a cross-national empirical analysis of the relationship between parties and the state in contemporary liberal democracies. Our analysis underscores the considerable importance of the state for political parties in general. It also highlights important differences between old and new democracies, as well as important regional differences in terms of the nature of the relationship between parties and the state in the recently established democracies. We argue that these different types of linkages are highly relevant for party system development and the nature of democracy.
Depressive Symptoms and Decision Making among African American Youth

Childhood and adolescent depression has emerged as a public health concern because of its impairment of functioning, particularly in the domains of decision making and self-efficacy. The present investigation examines the association between depressive symptoms and decision coping patterns among a nonreferred, nonclinical community sample of 276 low-income African American adolescents. The students ranged in age from 12 to 17 years. The Children's Depression Inventory was used to assess participants'depressive symptomatology. The Flinders Adolescent Decision Making Questionnaire was used for assessing participants' decision coping patterns. The instrument was group administered in classroom settings by the research staff. Findings indicated a significant association between depressive symptomatology and the use of maladaptive decision coping patterns. Perhaps increasing competence in decision making may have beneficial effects on overall mood and depressive symptoms among children and adolescents.
Stock Market Prices Do Not Follow Random Walks: Evidence from a Simple Specification Test

In this paper, we test the random walk hypothesis for weekly stock market returns by comparing variance estimators derived from data sampled at different frequencies. The random walk model is strongly rejected for the entire sample period (1962-1985) and for all sub-periods for a variety of aggregate returns indexes and size-sorted portfolios. Although the rejections are largely due to the behavior of small stocks, they cannot be ascribed to either the effects of infrequent trading or time-varying volatilities. Moreover, the rejection of the random walk cannot be interpreted as supporting a mean-reverting stationary model of asset prices, but is more consistent with a specific nonstationary alternative hypothesis.
Autonomy Support Versus Psychological Control, Perfectionism, and Taiwanese Adolescents’ Achievement Goals

ABSTRACT The author attempted to explore potential antecedents of achievement goals and relations of teacher and parental autonomy support versus psychological control to Taiwanese adolescents’ perfectionistic tendencies. A total of 512 eighth-grade students completed self-reported questionnaires assessing variables of interest. Results indicated that perceived autonomy support versus psychological control together with perfectionistic tendencies play a role in predicting Taiwanese adolescents’ achievement goal orientations. In addition, the present findings replicated effects of autonomy-supportive versus controlling social environment consistently found in Western cultures. The author also documented profiles of adolescents with different perfectionistic tendencies. Adaptive perfectionists reported higher levels of teachers’ autonomy support and lower levels of parental psychological control than did maladaptive perfectionists. Also, adaptive perfectionists were more likely to adopt approach-oriented goals.
The Development of Italian Low- and Very-low-birthweight Infants from Birth to 5 Years: The Role of Biological and Social Risks

This study attempted to determine how cognitive, motor, linguistic, and social competencies of preterm children develop from birth to five years in comparison with a group of fullterm children. The interaction between biological and social risks was considered in evaluating short- and long-term delays in development. The study was also designed to ascertain whether infant test scores of the first two years are predictive of later IQ scores. A total of 195 healthy Italian preterms (birthweight ≤ 2000 grams, without severe neonatal complications) were administered the Brunet-Lezine test at 6,12, and 24 months (corrected age), and 149 of them the Stanford-Binet test at 3,4, and 5 years (chronological age). The preterm group showed motor, cognitive, and social delays in the first year, linguistic delays until 24 months, and general cognitive delays until 5 years in comparison with the fullterm group. However, preterms' mean infant test scores and IQ scores fell within the normal range. The probability of delays in development was increased by the conditions of intra-uterine growth retardation and very-low-birthweight, and, after the first year of life, by a low level of paternal education. Brunet-Lezine test scores were predictive of later IQ scores, as were sex and parental education. In conclusion, preterm birth is correlated with delays in development, especially when it is associated with other biological and/or social risk factors.
K 1-channel blockade inhibits shear stress-induced pulmonary vasodilation in the ovine fetus

LAURENT STORME,1 ROBYN L. RAIRIGH,2 THOMAS A. PARKER,2 DAVID N. CORNFIELD,3 JOHN P. KINSELLA,2 AND STEVEN H. ABMAN2 1Service de Medecine Neonatale, Hôpital Jeanne de Flandre, CHRU de Lille, 59110 Lille, France; 2Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80218; and 3Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455
Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart

Executioner caspase-3 and -7 are proteases promoting cell death but non-apoptotic roles are being discovered. The heart expresses caspases only during development, suggesting they contribute to the organ maturation process. Therefore, we aimed at identifying novel functions of caspases in heart development. We induced simultaneous deletion of executioner caspase-3 and -7 in the mouse myocardium and studied its effects. Caspase knockout hearts are hypoplastic at birth, reaching normal weight progressively through myocyte hypertrophy. To identify the molecular pathways involved in these effects, we used microarray-based transcriptomics and multiplexed quantitative proteomics to compare wild type and executioner caspase-deficient myocardium at different developmental stages. Transcriptomics showed reduced expression of genes promoting DNA replication and cell cycle progression in the neonatal caspase-deficient heart suggesting reduced myocyte proliferation, and expression of non-cardiac isoforms of structural proteins in the adult null myocardium. Proteomics showed reduced abundance of proteins involved in oxidative phosphorylation accompanied by increased abundance of glycolytic enzymes underscoring retarded metabolic maturation of the caspase-null myocardium. Correlation between mRNA expression and protein abundance of relevant genes was confirmed, but transcriptomics and proteomics indentified complementary molecular pathways influenced by caspases in the developing heart. Forced expression of wild type or proteolytically inactive caspases in cultured cardiomyocytes induced expression of genes promoting cell division. The results reveal that executioner caspases can modulate heart’s cellularity and maturation during development, contributing novel information about caspase biology and heart development.
Suicidal Ideation and Comorbid Disorders in Adolescents and Young Adults Diagnosed with Asperger's Syndrome: A Population at Risk

ABSTRACT The purpose of this study was to examine the level of suicidal ideation and comorbid disorders (major depressive disorder, generalized anxiety disorder) among adolescents and young adults with diagnosed Asperger's syndrome (AS). A cross-sectional study using a self-administrated mail questionnaire and a Web-based questionnaire were used. Two samples were selected for this study. The first sample used snowball sampling, starting with parents of adolescents and young adults with diagnosed AS who participated in a qualitative study conducted in 2002. The second sample consisted of a volunteer sample of parents who visited Web sites for parents and individuals with diagnosed autism spectrum disorder. The sample included 10 adolescents and young adults with diagnosed AS. Fifty percent of the sample had a clinically significant level of suicidal ideation, 20% met criteria for a diagnosis of major depressive disorder, and 30% met criteria for generalized anxiety disorder.
Can parental responses to adult children with schizophrenia be conceptualized in terms of loss and grief? A case study analysis

It has been suggested that parental responses to adult children with schizophrenia may involve feelings of loss and grief, centred around loss of the pre-morbid version of their child. In this exploratory study, an in-depth case study analysis of four parental accounts of their responses was undertaken in order to obtain insights into whether these responses can be conceptualized in terms of loss and grief, with the aim of informing therapeutic practice with parents in this position. Information was also obtained on how parents coped with the reactions that their child's condition elicited in them. Data were analysed using Interpretative Phenomenological Analysis. In relation to the central research question, it was found that the perception of loss was not uniform amongst participants. Three acknowledged a sense of loss, at least to some extent, but one parent resisted such an interpretation because she perceived a continuity over time in her son's behaviour and she also challenged her son's diagnosis. One parent acknowledged a loss of his daughter's pre-morbid self but qualified this by pointing to her continued physical presence. The usefulness of existing models of grief is examined in light of the findings. The implications for the practice of counselling psychology are discussed.
Grandmothers Raising Grandchildren: An Exploration of Their Experiences and Emotions

A qualitative study was designed to provide an in-depth understanding of the experiences and emotions of grandmothers raising their grandchildren. Participants included 7 grandmothers ranging in age from 48 to 80. In-depth, semistructured interviews were used. A computer program, NUD*IST, was used for data coding, and careful and thorough readings were made of transcripts and field notes. The grandmothers' stories revealed common themes of anger, frustration, loss, hurt, and depression. There was also love, satisfaction, pride, joy, feeling needed and youthful, and other positive emotions. A key finding was that grandmothers who did not report depression had positive and helpful relationships with the parents of the grandchildren, whereas the grandmothers with persistent depression had conflictive involvement with the parents. The findings may be useful to counselors and family therapists in treating families headed by grandmothers.
Coerência textual: um estudo com jovens e adultos

Coherence is a linguistic phenomenon responsible for meaning construction which assures the understanding of a text. Investigations led by cognitive psychology, have invested efforts on the analysis of coherence from the perspective of those who receive the text. This study examined if the establishment of textual coherence is related to the acquisition of reading and writing amidst youths and adults, in literacy process, in a situation of text production. Fifteen to 45-year-old students, enrolled in the 1st and 2nd cycles of Basic Education for Youths and Adults at a public school, were individually requested to produce a original. The stories were analyzed according to specific indicators, contained in an analysis system, which expresses different levels concerning the establishment of coherence. Comparisons among the cycles were carried out. The results obtained reinforce a study performed with children. There are some indicators easier to be established than others. It can be said that formal education contributed to the establishment of coherence in stories production.
Are serum nitric oxide metabolites associated with fasting insulin among Iranian adults? (Tehran Lipid and Glucose Study)

ABSTRACT Aim: It has been suggested that insulin resistance is associated with altered nitric oxide (NO) homeostasis. There is however no population-based study documenting an association between fasting serum insulin and serum NO metabolites (NOx) with multivariable adjustment. This study was therefore designed to determine the association between serum NOx and fasting insulin levels and insulin resistance/sensitivity indices in a sample of a population-based study in Iran. Materials and methods: This study, performed within the framework of the Tehran Lipid and Glucose Study (TLGS), analyzed the data of 1518 non-diabetic subjects (955 women), aged 20–87 years, who had participated in phase III of the TLGS (2006–2008). Serum NOx concentrations were measured using the Griess method. Fasting serum insulin was measured by the electrochemiluminescence immunoassay method. Multiple regression analysis was used to determine the association between serum NOx concentration and quartiles of insulin and insulin resistance/sensitivity indices (HOMA1-IR, HOMA2-IR, and QUICKI). Results: NOx concentration in women only was weakly correlated with HOMA1-IR (r = 0.07, P = 0.03) and QUICKI (r = −0.07, P = 0.03), whereas no significant association was observed in men (P > 0.05). Marginally significant correlations were also found between serum NOx and fasting insulin concentration (r = 0.062, p = 0.057) and HOMA2-IR (r = 0.063, p = 0.053) in women. NOx concentration differed significantly between quartiles of insulin and insulin resistance/sensitivity indices among women and the total population (P < 0.05), associations which remained significant after age adjustment (P < 0.05), but not after adjustment for other confounding variables (P > 0.05). Conclusions: Fasting serum insulin level and insulin resistance/sensitivity indices are not associated with serum NOx level after multivariable adjustment.
Introduction: Issue Congruence and Political Responsiveness

It has long been realised that democratic governance requires a two-way flow of influence. Governments must be able to respond to what people want and people must be able to react to what governments do. These preconditions for democratic governance have been central to two research traditions on political representation. One of these, the responsible party approach, views policy change as a consequence of ‘electoral turnover’, while the other, the dynamic representation approach, focuses on policy change that occurs in ‘rational anticipation’ of electoral repercussions. The aim of this volume is to evaluate the state of political representation in contemporary Europe and to advance our understanding of the topic by presenting fresh insights both on the extent to which there exists issue congruence between voters and parties and the degree to which there is dynamic representation in the policy responses of representatives. This introduction describes in some detail the nature of the two approaches and then briefly summarises the contributions made in the remainder of the volume.
Qualitative Simulation and Its Application Framework in Human Reliability Analysis

Human reliability analysis in complicated industrial processes is facing to difficulties, such as insufficient knowledge utilization and simplex analytic means etc. This paper first introduces basic meanings and current research situation of human reliability analysis and qualitative simulation respectively, and then on the basis of it, considering current insufficiency of human reliability analysis methods, this paper points out the necessity to apply qualitative simulation thoughtway to carry out human reliability analysis. Furthermore, a framework of human reliability analysis based on qualitative simulation is proposed and some key issues are discussed, which lays a foundation for deeper application research of qualitative simulation in human reliability analysis in future.
Evaluating the Effectiveness of a Curriculum‐based Anti‐bullying Intervention Program in Greek Primary Schools

The present study reports the short‐ and long‐term effects of an anti‐bullying intervention program based on a particular set of curricular activities that aimed to create classroom opportunities for awareness raising, self‐reflection, and problem‐solving situations relevant to bullying. The core of the intervention was a four‐week period during which a series of activities were organised in each individual class. An experimental pre‐test/post‐test design with a control group was used. The sample consisted of 454 pupils (206 control: 123 boys and 83 girls; and 248 experimental: 126 boys and 122 girls) drawn from the fourth‐ to sixth‐grade classrooms of 10 primary schools in central Greece (mean age = 10.23, SD = .84). Data were collected using self‐report measures, before the intervention (December 2003), immediately after the intervention, at the end of the same school year (May 2004), and six months afterwards (November 2004). The results indicated that the program contributed to a positive reduction in outsider behaviour (children remaining uninvolved and thus silently allowing bullying to continue) and enhanced students’ self‐efficacy beliefs for both assertion and intervening in bully/victim incidents. However, the long‐term effectiveness of the program was limited. These findings have important implications for interventions to tackle the negative effects associated with bullying in schools.