Miracle-dz/UniFAR-FTUs huggingface dataset:
Amplitude and Phase Fluctuations for Gravitational Waves Propagating through Inhomogeneous Mass Distribution in the Universe

When a gravitational wave (GW) from a distant source propagates through the universe, its amplitude and phase change due to gravitational lensing by the inhomogeneous mass distribution. We derive the amplitude and phase fluctuations and calculate these variances in the limit of a weak gravitational field of density perturbation. If the scale of the perturbation is smaller than the Fresnel scale ~100 pc(f/mHz)-1/2 (f is the GW frequency), the GW is not magnified due to the diffraction effect. The rms amplitude fluctuation is 1%-10% for f > 10-10 Hz, but it is reduced to less than 5% for a very low frequency of f < 10-12 Hz. The rms phase fluctuation in the chirp signal is ~10-3 rad at the LISA frequency band (10-5 to 10-1 Hz). Measurements of these fluctuations will provide information about the matter power spectrum on the Fresnel scale ~100 pc.
Monitoring the athlete training response: subjective self-reported measures trump commonly used objective measures: a systematic review

Background Monitoring athlete well-being is essential to guide training and to detect any progression towards negative health outcomes and associated poor performance. Objective (performance, physiological, biochemical) and subjective measures are all options for athlete monitoring. Objective We systematically reviewed objective and subjective measures of athlete well-being. Objective measures, including those taken at rest (eg, blood markers, heart rate) and during exercise (eg, oxygen consumption, heart rate response), were compared against subjective measures (eg, mood, perceived stress). All measures were also evaluated for their response to acute and chronic training load. Methods The databases Academic search complete, MEDLINE, PsycINFO, SPORTDiscus and PubMed were searched in May 2014. Fifty-six original studies reported concurrent subjective and objective measures of athlete well-being. The quality and strength of findings of each study were evaluated to determine overall levels of evidence. Results Subjective and objective measures of athlete well-being generally did not correlate. Subjective measures reflected acute and chronic training loads with superior sensitivity and consistency than objective measures. Subjective well-being was typically impaired with an acute increase in training load, and also with chronic training, while an acute decrease in training load improved subjective well-being. Summary This review provides further support for practitioners to use subjective measures to monitor changes in athlete well-being in response to training. Subjective measures may stand alone, or be incorporated into a mixed methods approach to athlete monitoring, as is current practice in many sport settings.
Remodeling of Dendritic Spines in the Avian Vocal Motor Cortex Following Deafening Depends on the Basal Ganglia Circuit

&NA; Deafening elicits a deterioration of learned vocalization, in both humans and songbirds. In songbirds, learned vocal plasticity has been shown to depend on the basal ganglia‐cortical circuit, but the underlying cellular basis remains to be clarified. Using confocal imaging and electron microscopy, we examined the effect of deafening on dendritic spines in avian vocal motor cortex, the robust nucleus of the arcopallium (RA), and investigated the role of the basal ganglia circuit in motor cortex plasticity. We found rapid structural changes to RA dendritic spines in response to hearing loss, accompanied by learned song degradation. In particular, the morphological characters of RA spine synaptic contacts between 2 major pathways were altered differently. However, experimental disruption of the basal ganglia circuit, through lesions in song‐specialized basal ganglia nucleus Area X, largely prevented both the observed changes to RA dendritic spines and the song deterioration after hearing loss. Our results provide cellular evidence to highlight a key role of the basal ganglia circuit in the motor cortical plasticity that underlies learned vocal plasticity.
XP13512 [(±)-1-([(α-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: I. Design, Synthesis, Enzymatic Conversion to Gabapentin, and Transport by Intestinal Solute Transporters

Gabapentin is thought to be absorbed from the intestine of humans and animals by a low-capacity solute transporter localized in the upper small intestine. Saturation of this transporter at doses used clinically leads to dose-dependent pharmacokinetics and high interpatient variability, potentially resulting in suboptimal drug exposure in some patients. XP13512 [(±)-1-([(α-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid] is a novel prodrug of gabapentin designed to be absorbed throughout the intestine by high-capacity nutrient transporters. XP13512 was stable at physiological pH but rapidly converted to gabapentin in intestinal and liver tissue from rats, dogs, monkeys, and humans. XP13512 was not a substrate or inhibitor of major cytochrome P450 isoforms in transfected baculosomes or liver homogenates. The separated isomers of XP13512 showed similar cleavage in human tissues. The prodrug demonstrated active apical to basolateral transport across Caco-2 cell monolayers and pH-dependent passive permeability across artificial membranes. XP13512 inhibited uptake of 14C-lactate by human embryonic kidney cells expressing monocarboxylate transporter type-1, and direct uptake of prodrug by these cells was confirmed using liquid chromatography-tandem mass spectrometry. XP13512 inhibited uptake of 3H-biotin into Chinese hamster ovary cells overexpressing human sodium-dependent multivitamin transporter (SMVT). Specific transport by SMVT was confirmed by oocyte electrophysiology studies and direct uptake studies in human embryonic kidney cells after tetracycline-induced expression of SMVT. XP13512 is therefore a substrate for several high-capacity absorption pathways present throughout the intestine. Therefore, administration of the prodrug should result in improved gabapentin bioavailability, dose proportionality, and colonic absorption compared with administration of gabapentin.
Performance Analysis of CoDel and PIE for Saturated TCP Sources

In the recent years, the bufferbloat phenomenon was observed which is mainly due to oversized unmanaged buffers in the Internet. This triggered a new discussion of active queue management (AQM) algorithms in the IETF. "Controlled Delay" (CoDel) and "Proportional Integral controller Enhanced" (PIE) are considered as an alternative to "Random Early Detection" (RED). Their intention is both to take advantage of large buffers for occasional bursts and to limit queueing delays most of the time. Moreover, they are able to cope with varying bandwidth. In this paper, we study the performance of CoDel, PIE, and CoDel-ACT, which is an effective modification of CoDel that leads to better performance than CoDel in our studies. We experiment with saturated TCP sources and a fixed-bandwidth bottleneck link and focus on the delay-limiting phase of the algorithms. We investigate the impact of configuration parameters and traffic load on link utilization and queueing delay. We study the timely evolution of queuing delays and drop patterns, and point out significant differences among the algorithms. In particular, we show that CoDel's drop behavior changes over time and may lead to underutilization.
The Fairy-Ring Dance: Password Authenticated Key Exchange in a Group

In this paper, we study Password Authenticated Key Exchange (PAKE) in a group. First, we present a generic "fairy-ring dance" construction that transforms any secure two-party PAKE scheme to a group PAKE protocol while preserving the round efficiency in the optimal way. Based on this generic construction, we present two concrete instantiations based on using SPEKE and J-PAKE as the underlying PAKE primitives respectively. The first protocol, called SPEKE+, accomplishes authenticated key exchange in a group with explicit key confirmation in just two rounds. This is more round-efficient than any existing group PAKE protocols in the literature. The second protocol, called J-PAKE+, requires one more round than SPEKE+, but is computationally faster. Finally, we present full implementations of SPEKE+ and J-PAKE+ with detailed performance measurements. Our experiments suggest that both protocols are feasible for practical applications in which the group size may vary from three to several dozen. This makes them useful, as we believe, for a wide range of applications - e.g., to bootstrap secure communication among a group of smart devices in the Internet of Things (IoT).
User-Directed Analog Beamforming for Multiuser Millimeter-Wave Hybrid Array Systems

Beamforming design for millimeter-Wave hybrid array with the subarray structure is very challenging. There is neither known optimal solution that maximizes the sum rate capacity nor near-optimal solution. This paper proposes some low-complexity user-directed analog radio- frequency (RF) beamforming design schemes. The basic idea is to iteratively allocate different subarrays to different users such that users' channel correlation can be efficiently reduced via RF beamforming. Several new but less efficient schemes are also presented to shed light on RF beamforming design, and to serve as comparisons for the user-directed schemes. Simulation results are provided for these proposed schemes, existing ones in the literature and an upper-bound for hybird array with a fully-connected structure. The user-directed schemes demonstrate significantly better sum-rate and BER performance over other schemes, although the gap to the upperbound is still large.
[Cigarette smoking and sleep disturbance].

INTRODUCTION Sleep disturbances may make smoking cessation more difficult and relapses more frequent. STATE OF THE ART Nicotine increases vigilance and decreases sleeping time. Cigarette smoking is associated both with difficulty initiating and maintaining sleep. The disruption is associated with arousals on EEG recordings. Smoking promotes snoring and obstructive sleep apnoea. Insomnia is recognised as one of the criteria for nicotine withdrawal syndrome. Awakening from sleep and daytime sleepiness can occur frequently in this situation and are predictive factors for relapse. Nicotine replacement therapy itself induces frequent awakenings, a decrease in total sleep duration, early morning waking, dreams and sometimes nightmares with associated arousals on EEG. Sleep disruption is the most common side effect observed with bupropion when used as an aid in smoking cessation. PERSPECTIVES Sleep disturbance must be taken into account in smoking cessation programs. More detailed investigations are needed, both clinical studies looking at measures of the main sleep parameters using sleep diaries and more detailed studies using polysomnography. CONCLUSION In smokers, sleep disturbances must be taken into account, because they increase cardio-vascular and cerebro-vascular morbidity. During smoking cessation, relieving these disturbances should make quitting easier and prevent relapses.
Sensitivity of Direct Culture, Enrichment and PCR for Detection of Campylobacter jejuni and C. coli in Broiler Flocks at Slaughter

Broiler chicken flocks are a significant source of Campylobacter jejuni and Campylobacter coli that result in the major public health problem of campylobacteriosis. Accurate estimates of the prevalence of both C. coli and C. jejuni in flocks would enhance epidemiological understanding, risk assessment and control options. This study combined results from a panel of 10 detection tests (direct culture, enrichment and PCR) on caecal samples from flocks at slaughter. A parallel interpretation approach was used to determine the presence of Campylobacter spp. and for C. jejuni and C. coli individually. The sample was considered positive if at least one method detected the target and this interpretation was taken to represent a ‘proxy gold standard’ for detection in the absence of a gold standard reference test. The sensitivity of each individual method to detect Campylobacter spp. , C. jejuni and C. coli was then estimated relative to the proxy gold standard. Enrichment in adapted Exeter broth (deficient in polymyxin B) with a resuscitation step was 100% sensitive, whilst direct culture on modified charcoal cefoperazone deoxycholate agar (mCCDA) was highly sensitive (97.9%). Enrichment methods using Preston broth and Bolton broth were significantly less sensitive. Enrichment in Exeter broth promoted the recovery of C. jejuni, whilst enrichment in Bolton broth favoured C. coli. A RT‐PCR detection test could identify 80% of flocks that were co‐colonised with both species. This study found that 76.3% (n = 127) of flocks were colonised with Campylobacter spp. The majority (95.9%) of Campylobacter‐positive flocks were colonised with C. jejuni; however, approximately one‐third of positive flocks were simultaneously colonised with both C. jejuni and C. coli. The findings highlight the impact of different detection methodologies on the accuracy of the estimated incidence of both C. jejuni and C. coli entering the abattoir within broiler flocks and the associated public health risks.
Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis

Atopic dermatitis (AD), also known as eczema, is one of the most common chronic skin conditions worldwide, affecting up to 16% of children and 10% of adults. It is incurable and has significant psychosocial and economic impacts on the affected individuals. AD etiology has been linked to deficiencies in the skin barrier protein, filaggrin. In mammalian skin, l-histidine is rapidly incorporated into filaggrin. Subsequent filaggrin proteolysis releases l-histidine as an important natural moisturizing factor (NMF). In vitro studies were conducted to investigate the influence of l-histidine on filaggrin processing and barrier function in human skin-equivalent models. Our further aim was to examine the effects of daily oral l-histidine supplementation on disease severity in adult AD patients. We conducted a randomized, double-blind, placebo-controlled, crossover, nutritional supplementation pilot study to explore the effects of oral l-histidine in adult AD patients (n=24). In vitro studies demonstrated that l-histidine significantly increased both filaggrin formation and skin barrier function (P<0.01, respectively). Data from the clinical study indicated that once daily oral l-histidine significantly reduced (P<0.003) AD disease severity by 34% (physician assessment using the SCORingAD tool) and 39% (patient self-assessment using the Patient Oriented Eczema Measure tool) after 4 weeks of treatment. No improvement was noted with the placebo (P>0.32). The clinical effect of oral l-histidine in AD was similar to that of mid-potency topical corticosteroids and combined with its safety profile suggests that it may be a safe, nonsteroidal approach suitable for long-term use in skin conditions that are associated with filaggrin deficits such as AD.
Stability analysis of discrete-time fuzzy dynamic systems based on piecewise Lyapunov functions

This paper presents a stability analysis method for discrete-time Takagi-Sugeno fuzzy dynamic systems based on a piecewise smooth Lyapunov function. It is shown that the stability of the fuzzy dynamic system can be established if a piecewise Lyapunov function can be constructed, and moreover, the function can be obtained by solving a set of linear matrix inequalities that is numerically feasible with commercially available software. It is also demonstrated via numerical examples that the stability result based on the piecewise quadratic Lyapunov functions is less conservative than that based on the common quadratic Lyapunov functions.
Psychosocial Distress and Stroke Risk in Older Adults

Background and Purpose— To investigate the association of psychosocial distress with risk of stroke mortality and incident stroke in older adults. Methods— Data were from the Chicago Health and Aging Project, a longitudinal population-based study conducted in 3 contiguous neighborhoods on the south side of Chicago, IL. Participants were community-dwelling black and non-Hispanic white adults, aged 65 years and older (n=4120 for stroke mortality; n=2649 for incident stroke). Psychosocial distress was an analytically derived composite measure of depressive symptoms, perceived stress, neuroticism, and life dissatisfaction. Cox proportional hazards models examined the association of distress with stroke mortality and incident stroke over 6 years of follow-up. Results— Stroke deaths (151) and 452 incident strokes were identified. Adjusting for age, race, and sex, the hazard ratio (HR) for each 1-SD increase in distress was 1.47 (95% confidence interval [CI]=1.28–1.70) for stroke mortality and 1.18 (95% CI=1.07–1.30) for incident stroke. Associations were reduced after adjustment for stroke risk factors and remained significant for stroke mortality (HR=1.29; 95% CI=1.10–1.52) but not for incident stroke (HR=1.09; 95% CI=0.98–1.21). Secondary analyses of stroke subtypes showed that distress was strongly related to incident hemorrhagic strokes (HR=1.70; 95% CI=1.28–2.25) but not ischemic strokes (HR=1.02; 95% CI=0.91–1.15) in fully adjusted models. Conclusions— Increasing levels of psychosocial distress are related to excess risk of both fatal and nonfatal stroke in older black and white adults. Additional research is needed to examine pathways linking psychosocial distress to cerebrovascular disease risk.
COMSAT: Residue contact prediction of transmembrane proteins based on support vector machines and mixed integer linear programming

In this article, we present COMSAT, a hybrid framework for residue contact prediction of transmembrane (TM) proteins, integrating a support vector machine (SVM) method and a mixed integer linear programming (MILP) method. COMSAT consists of two modules: COMSAT_SVM which is trained mainly on position–specific scoring matrix features, and COMSAT_MILP which is an ab initio method based on optimization models. Contacts predicted by the SVM model are ranked by SVM confidence scores, and a threshold is trained to improve the reliability of the predicted contacts. For TM proteins with no contacts above the threshold, COMSAT_MILP is used. The proposed hybrid contact prediction scheme was tested on two independent TM protein sets based on the contact definition of 14 Å between Cα‐Cα atoms. First, using a rigorous leave‐one‐protein‐out cross validation on the training set of 90 TM proteins, an accuracy of 66.8%, a coverage of 12.3%, a specificity of 99.3% and a Matthews' correlation coefficient (MCC) of 0.184 were obtained for residue pairs that are at least six amino acids apart. Second, when tested on a test set of 87 TM proteins, the proposed method showed a prediction accuracy of 64.5%, a coverage of 5.3%, a specificity of 99.4% and a MCC of 0.106. COMSAT shows satisfactory results when compared with 12 other state‐of‐the‐art predictors, and is more robust in terms of prediction accuracy as the length and complexity of TM protein increase. COMSAT is freely accessible at http://hpcc.siat. ac.cn/COMSAT/. Proteins 2016; 84:332–348. © 2016 Wiley Periodicals, Inc.
Huntington's disease

Huntington's disease (HD) is an autosomal dominant disorder of midlife onset, characterized by progressive involuntary choreiform movements, psychologic change, and dementia. In 1980, funded by the NINCDS, we established a center for the study of HD. This report presents a summary of our contributions to the investigation of this tragic disorder and a review of current ideas about the disease.
Influence of Fibre Taper on the Interfacial Shear Stress in Fibre-Reinforced Composite Materials during Elastic Stress Transfer

The paper is concerned with finite element (FE) analysis of stress transfer from an elastic matrix to an elastic fibre, which need not be a uniform cylinder, in a fibre-reinforced composite material. Axisymmetric models of fibres embedded in co-axial cylindrical matrices were investigated by the FE method. Fibre shapes investigated were cylindrical, ellipsoidal, paraboloidal taper and conical taper. The effects of varying the fibre aspect ratio, q (ranging 200 to 3500) and Young's modulus (relative to that of the matrix), E f /E m (ranging 103 to 106) were investigated. The results show that ellipsoidal and parabolic tapers lead to a similar distribution of interfacial shear stress (τ) to that observed for a uniform cylindrical fibre, except that the magnitude of the stress is higher. For a conical taper (except for q = 200, E f /E m = 106), the interfacial stress increases to a maximum between the centre and the end of the fibre and then decreases towards the fibre ends. The effect of fibre taper on the distribution of τvalues is reflected in the axial tensile stress, σz , distribution induced in a fibre. For example, for a fibre with a conical taper, the distribution of τ values can lead to an even distribution of σz along the length of a fibre.
HIV-Related Stigma, Isolation, Discrimination, and Serostatus Disclosure

Background: Little is known globally about the perspectives of people living with HIV/AIDS (PLWHA) on perceived HIV-related stigma and its consequences. Methods: Cross-sectional study (January-March 2010) of perceived HIV-related stigma among PLWHA (N = 2035) using a standardized questionnaire. Findings: Thirty-seven percent of respondents reported loneliness as a result of their HIV status. Depression was reported by 27%. While 96% reported disclosing their HIV status to at least 1 person, 17% of patients who reported being in a long-term sexual relationship had not disclosed their status to their partner. Variables associated with perceived stigma were living in Asia-Pacific versus other regions (odds ratio [OR]: 2.77; 95% confidence interval [CI] 1.96-3.92); having experienced body/face changes; reported depression (OR: 1.25; 95% CI 1.11-1.38); and nondisclosure of HIV status (OR: 1.75; 95% CI 1.28-2.41). Conclusion: Thirty years into the HIV pandemic, perceived HIV stigma, isolation, and discrimination persist and are associated with loneliness and depression among PLWHA.
The Malaysian Medication Adherence Scale (MALMAS): Concurrent Validity Using a Clinical Measure among People with Type 2 Diabetes in Malaysia

Medication non-adherence is a prevalent problem worldwide but up to today, no gold standard is available to assess such behavior. This study was to evaluate the psychometric properties, particularly the concurrent validity of the English version of the Malaysian Medication Adherence Scale (MALMAS) among people with type 2 diabetes in Malaysia. Individuals with type 2 diabetes, aged 21 years and above, using at least one anti-diabetes agent and could communicate in English were recruited. The MALMAS was compared with the 8-item Morisky Medication Adherence Scale (MMAS-8) to assess its convergent validity while concurrent validity was evaluated based on the levels of glycated hemoglobin (HbA1C). Participants answered the MALMAS twice: at baseline and 4 weeks later. The study involved 136 participants. The MALMAS achieved acceptable internal consistency (Cronbach’s alpha=0.565) and stable reliability as the test-retest scores showed fair correlation (Spearman’s rho=0.412). The MALMAS has good correlation with the MMAS-8 (Spearman’s rho=0.715). Participants who were adherent to their anti-diabetes medications had significantly lower median HbA1C values than those who were non-adherence (7.90 versus 8.55%, p=0.032). The odds of participants who were adherent to their medications achieving good glycemic control was 3.36 times (95% confidence interval: 1.09-10.37) of those who were non-adherence. This confirms the concurrent validity of the MALMAS. The sensitivity of the MALMAS was 88.9% while its specificity was 29.6%. The findings of this study further substantiates the reliability and validity of the MALMAS, in particular its concurrent validity and sensitivity for assessing medication adherence of people with type 2 diabetes in Malaysia.