Miracle-dz/UniFAR-FTUs huggingface dataset:
Cyberbullying: Impacting Today’s Youth

Cyberbullying is becoming a major concern surrounding the adolescent population because of the increased use in the internet and social networking sites. Studies show that cyberbullying can cause mental health concerns in adolescents who have been victimized, leaving them feeling lonely, depressed, and rejected. The purpose of this study was to explore the experiences of high school students who have been victimized by cyberbullying and to explore the relationship between cyberbully victimization and suicide. An anonymous mixed methods study was utilized and formatted with both quantitative and qualitative questions. The survey was distributed by email to students enrolled in the Bachelors of Social Work program at the University of St. Thomas and St. Catherine University and asked respondents specific questions in regards to their personal experience being victimized by cyberbullying and the impacts it had on them. The results were analyzed quantitatively using descriptive statistics and independent t-test and analyzed qualitatively using a content analysis approach. Results indicated that high school students who were victimized by cyberbullying experienced negative emotional impacts including feeling sad, helpless and hopeless, frustrated, and low self-esteem. The results of this study did not find a significant relationship between cyberbully victimization and suicide but did find that respondents reported feeling suicidal in the open-ended responses. Results from this study were consistent with pre-existing literature. CYBERBULLYING: IMPACTING TODAY’S 2
A Randomized Controlled Trial Shows that both 14-Day Hybrid and Bismuth Quadruple Therapies Cure Most Patients with Helicobacter pylori Infection in Populations with Moderate Antibiotic Resistance

ABSTRACT Hybrid therapy is a novel two-step treatment achieving a high eradication rate for Helicobacter pylori infection. Currently, whether this new therapy achieves a higher eradication rate than bismuth quadruple therapy remains an unanswered question. The aim of this prospective, randomized comparative study was to investigate the efficacies of 14-day hybrid therapy and bismuth quadruple therapy in the treatment of H. pylori infection. From July 2013 to June 2015, eligible H. pylori-infected subjects were randomly assigned to receive either 14-day bismuth quadruple therapy (pantoprazole, bismuth subcitrate, tetracycline, and metronidazole for 14 days) or 14-day hybrid therapy (a 7-day dual therapy with pantoprazole plus amoxicillin, followed by a 7-day quadruple therapy with pantoprazole plus amoxicillin, clarithromycin, and metronidazole). H. pylori status was examined 6 weeks after the end of treatment. Three hundred thirty H. pylori-infected participants were randomized to receive 14-day bismuth quadruple therapy (n = 164) or 14-day hybrid therapy (n = 166). The eradication rates by intention-to-treat analysis were similar: 93.9% versus 92.8%, respectively (95% confidence interval [CI], −4.3% to 5.4%; P = 0.68). Per-protocol analysis yielded similar results (96.7% versus 94.9%, respectively; P = 0.44). However, bismuth quadruple therapy had a higher frequency of adverse events than hybrid therapy (55.5% versus 15.7%, respectively; 95% CI, 30.4% to 49.2%; P < 0.001). The two treatments exhibited comparable drug adherence (93.9% versus 97%, respectively). The resistance rates of antibiotics were: clarithromycin, 16.7% of patients; amoxicillin, 1.3%; metronidazole, 25%; and tetracycline, 0%. In the bismuth quadruple therapy group, the eradication rate of metronidazole-resistant strains was lower than that of metronidazole-susceptible strains (70.0% versus 96.4%, respectively; P = 0.04). In the hybrid therapy group, no significant impact of clarithromycin or metronidazole resistance on eradication rates was identified. Both 14-day hybrid and bismuth quadruple therapies cure most patients with H. pylori infection in populations with moderate antibiotic resistance. However, the 14-day hybrid therapy has fewer adverse effects than the bismuth quadruple therapy. (This study has been registered at ClinicalTrials.gov under identifier NCT02541864.)
Perturbed reward processing in pediatric bipolar disorder: an antisaccade study

Pediatric bipolar disorder is a severe and impairing illness. Characterizing the impact of pediatric bipolar disorder on cognitive function might aid in understanding the phenomenology of the disorder. While previous studies of pediatric bipolar disorder have reported deficits in cognitive control and reward behavior, little is understood about how affective processes influence behavioral control. Relative to prior studies using manual-response paradigms, eye movement tasks provide a more precise assessment of reward sensitivity and cognitive and motor control. The current study compares 20 youths with bipolar disorder (mean age = 13.9 years ± 2.22) and 23 healthy subjects (mean age = 13.8 years ± 2.49) on a mixed pro—antisaccade task with monetary incentives. On both types of saccades, participants were presented with three types of incentives: those where subjects can win money, lose money, or neither win nor lose money. Impaired reward processing was found in youths with bipolar disorder relative to controls, particularly on antisaccades. This difference was reflected in lower error rates during incentive trials in the control but not in the bipolar disorder group. By comparison, no group differences were found on prosaccade trials. The results provide further evidence for deficits in cognitive and reward processing in bipolar disorder.
Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development.

OBJECTIVE Neuregulin 1 (NRG1) is a multifunctional neurotrophin that mediates neurodevelopment and schizophrenia risk. The NRG1 gene undergoes extensive alternative splicing, and association of brain NRG1 type IV isoform expression with the schizophrenia-risk polymorphism rs6994992 is a potential mechanism of risk. Novel splice variants of NRG1-IV (NRG1-IVNV), with predicted unique signaling capabilities, have been cloned in fetal brain tissue. The authors investigated the temporal dynamics of transcription of NRG1-IVNV, compared with the major NRG1 isoforms, across human prenatal and postnatal prefrontal cortical development, and they examined the association of rs6994992 with NRG1-IVNV expression. METHOD NRG1 type I-IV and NRG1-IVNV isoforms were evaluated with quantitative real-time polymerase chain reaction in human postmortem prefrontal cortex tissue samples at 14 to 39 weeks gestation and postnatal ages 0-83 years. The association of rs6994992 genotype with NRG1-IVNV expression and the subcellular distribution and proteolytic processing of NRG1-IVNV isoforms were also determined. RESULTS Expression of NRG1 types I, II, and III was temporally regulated during prenatal and postnatal neocortical development. NRG1-IVNV was expressed from 16 weeks gestation until age 3. Homozygosity for the schizophrenia risk allele (T) of rs6994992 conferred lower cortical NRG1-IVNV levels. Assays showed that NRG1-IVNV is a novel nuclear-enriched, truncated NRG1 protein resistant to proteolytic processing. CONCLUSIONS To the authors' knowledge, this study provides the first quantitative map of NRG1 isoform expression during human neocortical development and aging. It identifies a potential mechanism of early developmental risk for schizophrenia at the NRG1 locus, involving a novel class of NRG1 proteins.
Hot and cold cognition in unmedicated depressed subjects with bipolar disorder.

OBJECTIVES Neuropsychological studies in subjects with bipolar disorder (BD) have reported deficits on a variety of cognitive measures. However, because the majority of subjects were medicated at the time of testing in previous studies, it is currently unclear whether the pattern of deficits reported is related to BD itself or to psychotropic medication. We addressed this issue by examining cognitive performance in a group of unmedicated, currently depressed subjects with BD. METHODS Forty-nine unmedicated subjects who met DSM-IV criteria for BD, depressed phase, and 55 control subjects participated in this study. Most patients were diagnosed with bipolar II disorder. Performance on emotion-dependent, or 'hot', and emotion-independent, or 'cold', cognitive tasks was assessed using tests from the Cambridge Neuropsychological Test Automated Battery. RESULTS The groups were well matched with respect to general intelligence and demographic variables. Deficits in the unmedicated depressed BD group were apparent on tests tapping 'hot' cognitive processing, for example the Cambridge Gamble task and the Probabilistic Reversal Learning task. However, other than a deficit on the Spatial Span test in the depressed BD subjects, the groups performed equivalently on most measures of 'cold' cognitive processing, for example visual memory, attention, and working memory. CONCLUSIONS These data suggest that deficits on tests involving reward processing, short-term spatial memory storage, and sensitivity to negative feedback in depressed BD subjects represent an effect of the illness itself and not mood-stabilizing medication.
Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt

The interplay between canonical and non‐canonical Wnt pathways in development and tumorigenesis is tightly regulated. In this review we will describe the yin and the yang of canonical and non‐canonical Wnt signaling pathways during melanocyte development, and melanoma genesis. Canonical Wnt signaling, represented by Wnts such as Wnt1 and Wnt3A, signals via β‐catenin to promote melanocyte differentiation and tumor development. Non‐canonical Wnt signaling, specifically Wnt5A, regulates canonical pathways, and signals to induce melanoma metastasis. This review will focus on the role of Wnt5A during melanoma progression, and its relationship to canonical Wnt signaling.
SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN ENDOGENOUS CANDIDA ENDOPHTHALMITIS AND THEIR CLINICAL RELEVANCE

Purpose: To describe vitreal, retinal, and choroidal features of eyes affected by Endogenous candida endophthalmitis (ECE) analyzed by spectral domain optical coherence tomography (SD-OCT) and to evaluate their clinical impact. Methods: Medical records and SD-OCT images from eyes diagnosed with ECE at four retina and uveitis tertiary referral centers were retrospectively evaluated. Spectral domain optical coherence tomography images were analyzed to evaluate the structural changes occurring in the vitreous, the retina, and the choroid in areas involved by ECE. Baseline and final best-corrected visual acuity were correlated with SD-OCT findings. Results: Fifteen eyes from nine patients were enrolled. Vitreous involvement (vitreous cells, posterior hyaloid thickening) was detected in 13/15 eyes. Peculiar hyper-reflective preretinal aggregates obscuring the underlying retina because of a shadowing effect (“rain-cloud” sign) were noticed in all eyes with vitreous involvement. Two patterns of retinal and choroidal findings were identified: the first (six eyes) confined within the inner retinal layers (Intraretinal Pattern), the second (nine eyes) involving both retina (full thickness) and choriocapillaris (Chorioretinal Pattern). None of the eyes showed both patterns. None of the eyes, regardless the pattern, showed choroidal thickening. Baseline best-corrected visual acuity was not associated with OCT pattern (P = 0.09). On the contrary, final best-corrected visual acuity was significantly higher in patients showing Intraretinal Pattern (∼20/25, 0.06 ± 0.08 LogMAR) than in subjects with Chorioretinal Pattern (∼20/50, 0.44 ± 0.30 LogMAR) (P = 0.01). Conclusion: Endogenous candida endophthalmitis showed peculiar features on SD-OCT. Two distinct patterns of chorioretinal involvement influencing the final best-corrected visual acuity were identified. Spectral domain optical coherence tomography could be useful in the diagnosis, management, and outcome prediction in ECE.
The Effectiveness of the Achievable Dream Parent Involvement Program

The purpose of this mixed methods study is to determine if An Achievable Dream Academies are implementing an environment that is welcoming and inclusive of families. Based on the outcomes, decisions will be made to determine if the environment is inclusive or needs to be revisited to encourage family involvement. Participants included the 5, 7, 8, 10, and 11 grade families at An Achievable Dream Academy and An Achievable Dream Middle and High School in Newport News, Virginia. The study used the CIPP model of program evaluation to guide data collect on the context, input, process, and products of the parent involvement program. Both quantitative and qualitative data were collected using parent surveys, focus groups, home and school documents, and behavior, attendance, and SOL data. The study illuminated the successes and challenges of the program as well as areas of recommended improvement. The results indicated that there was a high level of parent involvement but it did not greatly impact the students’ success. With ongoing program monitoring and evaluation, the program can overcome these challenges and make recommended changes that will result in increased successes for the school and students. Recommendations for future research and program improvement include conducting a comparison study on AAD and a similar program, identifying what factors impact student success, and understanding the factors impacting teacher resistance.
Journalists in times of crisis: Experiences and practices of Palestinian journalists during the 2014 Gaza war

ABSTRACT This study explores the experiences and practices of Palestinian journalists working for Palestinian media outlets during the 2014 Gaza war. Our findings, based on data gathered from 10 in-depth interviews, indicate that the practices of Palestinian reporters and editors who covered the 2014 Gaza war were shaped by their personal experiences during the war and by a strong motivation to represent the Palestinian narrative, perspective, and suffering in the conflict with Israel.
WEALTH-BASED INEQUALITY IN CHILD IMMUNIZATION IN INDIA: A DECOMPOSITION APPROACH

Summary Despite years of health and medical advancement, children still suffer from infectious diseases that are vaccine preventable. India reacted in 1978 by launching the Expanded Programme on Immunization in an attempt to reduce the incidence of vaccine-preventable diseases (VPDs). Although the nation has made remarkable progress over the years, there is significant variation in immunization coverage across different socioeconomic strata. This study attempted to identify the determinants of wealth-based inequality in child immunization using a new, modified method. The present study was based on 11,001 eligible ever-married women aged 15–49 and their children aged 12–23 months. Data were from the third District Level Household and Facility Survey (DLHS-3) of India, 2007–08. Using an approximation of Erreyger’s decomposition technique, the study identified unequal access to antenatal care as the main factor associated with inequality in immunization coverage in India.
MiR-650 represses high-risk non-metastatic colorectal cancer progression via inhibition of AKT2/GSK3β/E-cadherin pathway

Although 5-year survival rate of non-metastatic colorectal cancer (CRC) is high, about 10% of patients in stage I and II still develop into metastatic CRC and eventually die after resection. Currently, there is no effective biomarker for predicting the prognosis of non-metastatic CRC in clinical practice. In this study, we identified miR-650 as a biomarker for prognosis prediction. We observed that the expression of miR-650 in tumor tissues had a positive association with overall survival. MiR-650 inhibited cell growth and invasion in vitro and in vivo. Furthermore, miR-650 targeted AKT2 and repressed the activation of the AKT pathway (AKT2/GSK3β/E-cadherin). Thus it induced the translocation of E-cadherin and β-catenin in cancer cells. Our results highlight the potential of miR-650 as a prognostic prediction biomarker and therapeutic target in non-metastatic CRC via inhibition of the AKT2/GSK3β/E-cadherin pathway.
Differentiation of mesenchymal stem cell in the microenviroment of retinitis pigmentosa 窑

·AIM: To access the differentiation of rat mesenchymal stem cell (MSC) in the microenvironment of retinal degeneration induced by the administration of sodium iodate. ·METHODS: cultured Lewis rat MSC were injected into the sub-retinal space of NaIO3 induced retinal degeneration rat eyes (30g/L NaIO3 100mg/kg). To observe the trace and differentiation of MSC by immuno-fluorescent method successively in 5 weeks after the surgery. ·RESULTS: The majority of the transplanted cells stay in retinal pigment epithelium layer and cones & rods layer. From the 2nd week after transplantation, the engrafted MSC express PCK and rhodopsin under fluorescent microscope. ·CONCLUSION: MSC can survive mainly in the outer layer of retina in the microenvironment of retinal degeneration and differentiate forward the RPE cell and photoreceptor. ·
Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy

M.K. was supported by the Melbourne Research Scholarship from the University of Melbourne. D.B. A was funded by a Newton Fund RCUK-CONFAP Grant awarded by The Medical Research Council (MRC) and Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) (MR/M026302/1), the Jack Brockhoff Foundation (JBF 4186, 2016), and a C. J Martin Research Fellowship from the National Health and Medical Research Council of Australia (APP1072476).
Attachment security as a basis for gratitude: an empirical investigation

There is a lack of research examining how individual differences in trait gratitude develop and the field lacks an adequate theoretical understanding of the gratitude construct. We propose that attachment processes influence gratitude development and explore the relationship between individual differences in attachment functioning and state and trait gratitude. It was expected that both attachment avoidance and anxiety would be negatively related to state and trait gratitude and attachment security would be positively related to gratitude. Undergraduate students (N = 608) were recruited over three data collection phases and completed a battery of online questionnaires for course credit. Results supported the main hypothesis although the relationships were small. Attachment security was the strongest predictor of gratitude and uniquely accounted for variability in gratitude after demographic variables, state affect, and attachment avoidance and anxiety were controlled. Attachment avoidance also uniquely predicted gratitude whereas attachment anxiety had a complex relationship with gratitude which is discussed in detail within the paper. The findings demonstrate the value of attachment theory as a framework for exploring in more depth the gratitude construct and is evidence to encourage further research using this
Production of sludge-incorporated paver blocks for efficient waste management

ABSTRACT Waste management plays a vital role in the reuse of industry wastes in to useful conversions. The treatment of effluents from the combined textile effluent treatment plant and hypo sludge from the paper industry results in sludge generation, which poses a huge challenge for its disposal. Therefore, an eco-friendly attempt is made to utilize them in the production of paver blocks. Paver blocks are construction units that have vast applications in street roads, walking paths, fuel stations, and so on. In this study, an innovative attempt has been made to manufacture paver blocks incorporating textile effluent treatment plant sludge and hypo sludge, to utilize them in suitable proportions. The effect of adding silica fume and polypropylene fibre in paver blocks has also been studied. Paver blocks containing sludge with different proportions were cast based on the recommendations in Indian Standards (IS) 15658, and the test results were compared with the nominal M20 grade and M30 grade paver blocks. The outcomes of the paver block combinations were studied and found to be an effective utilization of sludge with substantial cement replacement of up to 35%, resulting in effective waste management for specific industries. Implications: Presently, paver blocks are construction units that have vast application in street roads and other constructions like walking paths, fuel stations, and so on. Also, paver blocks possess easy maintenance during breakages. Based on this application, an innovative attempt has been made to manufacture paver blocks incorporating textile effluent treatment plant sludge and hypo sludge to utilize them in suitable proportions.
Psychopathology in the parents of children with conduct disorder and hyperactivity.

Abstract The biological parents of 86 outpatient children aged 6 to 1 3 years were assessed using a structured diagnostic interview. Both mothers and fathers of children with Conduct Disorder (CD) (N = 37) were more likely to exhibit Antisocial Personality Disorder, and fathers were more likely to abuse substances. CD mothers exhibited more depression and the triad of Antisocial Personality Disorder. Substance Abuse, or Somatization Disorder. In contrast. Attention Deficit Disorder with Hyperactivity (ADD/H) (N = 18) was not associated with any parental disorder. However, fathers of children with both CD and ADD/H, which is associated with greater aggression and persistent law-breaking in children than CD alone, were markedly more likely to have a history of aggression, arrest, and imprisonment. These results confirm findings that CD is linked to parental psychopathology but ADD/ H is not. When CD and ADD/H co-occur, however, there is markedly more aggression and illegal activity in both fathers and children. J. Am. Acad. Child. Adolesc Psychiatry , 1988, 27. 2:163–170.
Accuracy, reliability, and efficiency of intraoral scanners for full-arch impressions: a systematic review of the clinical evidence.

OBJECTIVES The interest on intraoral scanners for digital impressions has been growing and new devices are continuously introduced on the market. It is timely to verify whether the several scanners proposed for full-arch digital impressions have been tested under clinical conditions for validity, repeatability, reproducibility, as well as for time efficiency, and patient acceptance. SEARCH METHODS An electronic search of the literature was conducted through PubMed, Scopus, Cochrane Library, Web of Science, and Embase, entering the query terms 'digital impression', 'intraoral digital impression', 'intraoral scanning', 'intraoral scanner', 'intraoral digital scanner', combined by the Boolean operator 'OR'. No language or time limitation was applied. SELECTION CRITERIA Only studies where digital full-arch impressions had been recorded intraorally were considered. RESULTS In only eight studies full-arch scans had been performed intraorally. Only four studies reported data on validity, repeatability, reproducibility of digital measurements and their samples were limited to subjects in complete permanent dentition. Only two intraoral scanners, Lava COS and iTero, were tested. Scanning times were measured in six studies and varied largely. Patients' acceptance of intraoral scanning was evaluated in four studies, but it was not specifically assessed for children. CONCLUSIONS The scientific evidence so far collected on intraoral scanning is neither exhaustive, nor up-to-date. Data from full-arch scans performed in children should be collected. For a meaningful assessment of time efficiency, agreement should be reached on the procedural steps to be included in the computation of scanning time.