Miracle-dz/UniFAR-FTUs huggingface dataset:
Exceptions and aspects: the devil is in the details

It is usually assumed that the implementation of exception handling can be better modularized by the use of aspect-oriented programming (AOP). However, the trade-offs involved in using AOP with this goal are not well-understood. This paper presents an in-depth study of the adequacy of the AspectJ language for modularizing exception handling code. The study consisted in refactoring existing applications so that the code responsible for implementing heterogeneous error handling strategies was moved to separate aspects. We have performed quantitative assessments of four systems - three object-oriented and one aspect-oriented - based on four quality attributes, namely separation of concerns, coupling, cohesion, and conciseness. Our investigation also included a multi-perspective analysis of the refactored systems, including (i) the reusability of the aspectized error handling code, (ii) the beneficial and harmful aspectization scenarios, and (iii) the scalability of AOP to aspectize exception handling in the presence of other crosscutting concerns.
Is homeostatic sleep regulation under low sleep pressure modified by age?

STUDY OBJECTIVES We have previously shown that healthy older volunteers react with an attenuated frontal predominance of sleep electroen-cephalogram (EEG) delta activity in response to high sleep pressure. Here, we investigated age-related changes in homeostatic sleep regulation under low sleep pressure conditions, with respect to regional EEG differences and their dynamics. DESIGN Analysis of the sleep EEG during an 8-hour baseline night, during a 40-hour multiple nap protocol (150 minutes of wakefulness and 75 minutes of sleep) and during the following 8-hour recovery night under constant posture conditions. SETTING Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland PARTICIPANTS Sixteen young (20-31 years) and 15 older (57-74 years) healthy volunteers INTERVENTIONS N/A. MEASUREMENTS AND RESULTS All-night EEG spectra revealed an increase in spindle activity (13-15.25 Hz) for both age groups, but only in the young did we find a significant decrease of delta activity (0.5-1.25 Hz) in response to low sleep pressure conditions, predominantly in occipital brain regions. However, delta activity during the first non-rapid eye movement (NREM) sleep episode was equally reduced in both age groups. This response lasted significantly longer in the young (across the first 2 NREM sleep episodes) than in the older participants (only the first NREM sleep episode). CONCLUSION The initial EEG delta response to low sleep pressure was similar in healthy older and young participants. Therefore, age-related sleep deteriorations cannot solely be attributed to alterations in the homeostatic sleep-regulatory system. It is, rather, the interplay of circadian and homeostatic factors of sleep regulation, which is changed with aging.
Hybridisation of dental hard tissues with modified adhesive systems : therapeutic impact of bioactive silicate compounds on bonding to dentine

Objectives. This study aimed at evaluating the therapeutic bioactive effects on the bond strength of three experimental bonding agents containing modified Portland cement-based micro-fillers applied to acid-etched dentin and submitted to aging in simulated body fluid solution (SBS). Confocal laser (CLSM) and scanning electron microscopy (SEM) were also performed. Methods. A type-I ordinary Portland cement was tailored using different compounds such as sodium–calcium–aluminum–magnesium silicate hydroxide (HOPC), aluminum–magnesium–carbonate hydroxide hydrates (HCPMM) and titanium oxide (HPCTO) to create three bioactive micro-fillers. A resin blend mainly constituted by Bis-GMA, PMDM and HEMA was used as control (RES-Ctr) or mixed with each micro-filler to create three experimental bonding agents: (i) Res-HOPC, (ii) Res-HCPMM and (iii) Res-HPCTO. The bonding agents were applied onto 37% H3PO4-etched dentin and light-cured for 30 s. After build-ups, they were prepared for micro-tensile bond strength ( TBS) and tested after 24 h or 6 months of SBS storage. SEM analysis was performed after de-bonding, while CLSM was used to evaluate the ultra-morphology/nanoleakage and the mineral deposition at the resin–dentin interface. Results. High TBS values were achieved in all groups after 24 h. Only Res-HOPC and ResHCPMM showed stable TBS after SBS storage (6 months). All the resin–dentin interfaces created using the bonding agents containing the bioactive micro-fillers tested in this study showed an evident reduction of nanoleakage and mineral deposition after SBS storage. Conclusion. Resin bonding systems containing specifically tailored Portland cement microfillers may promote a therapeutic mineral deposition within the hybrid layer and increase the durability of the resin–dentin bond. © 2013 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved. ∗ Corresponding author. Tel. : +44 207 188 3874; fax: +44 020 71881823. E-mail address: salvatore.sauro@kcl.ac. uk (S. Sauro). 0109-5641/$ – see front matter © 2013 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved. http://dx.doi. org/10.1016/j.dental. 2013.04. 001 730 d e n t a l m a t e r i a l s 2 9 ( 2 0 1 3 ) 729–741
Rat subicular networks gate hippocampal output activity in an in vitro model of limbic seizures

Evidence obtained from human epileptic tissue maintained in vitro indicates that the subiculum may play a crucial role in initiating epileptiform discharges in patients with mesial temporal lobe epilepsy. Hence, we used rat hippocampus–entorhinal cortex (EC) slices to identify the role of subiculum in epileptiform synchronization during bath application of 4‐aminopyridine (4AP, 50 μm). In these slices, fast CA3‐driven interictal‐like events were restricted to the hippocampal CA3/CA1 areas and failed to propagate to the EC where slow interictal‐like and ictal‐like epileptiform discharges were recorded. However, antagonizing GABAA receptors with picrotoxin (50 μm) made CA3‐driven interictal activity spread to EC. Sequential field potential analysis along the CA3–CA1–subiculum axis revealed that the amplitude of CA3‐driven interictal discharges recorded in the presence of 4AP only diminished within the subiculum. Furthermore, CA1 electrical stimulation under control conditions elicited little or no subicular activation and never any response in EC; in contrast, robust subicular discharges that spread to EC could be evoked after picrotoxin. Intracellular recordings indicated that potentiation by picrotoxin was associated with blockade of hyperpolarizing IPSPs in subicular cells. Finally, when surgically isolated from adjacent structures, the subiculum generated low‐amplitude synchronous discharges that corresponded to an intracellular hyperpolarization–depolarization sequence, were resistant to glutamatergic antagonists, and represented the activity of synchronized interneuronal networks. Bath application of picrotoxin abolished these 4AP‐induced events and in their place robust network bursting occurred. In conclusion, our study demonstrates that the subiculum plays a powerful gating role on hippocampal output activity. This function depends on GABAA receptor‐mediated inhibition and controls hippocampal–parahippocampal interactions that are known to modulate limbic seizures.
Binding, Conformational Transition and Dimerization of Amyloid-β Peptide on GM1-Containing Ternary Membrane: Insights from Molecular Dynamics Simulation

Interactions of amyloid-β (Aβ) with neuronal membrane are associated with the progression of Alzheimer’s disease (AD). Ganglioside GM1 has been shown to promote the structural conversion of Aβ and increase the rate of peptide aggregation; but the exact nature of interaction driving theses processes remains to be explored. In this work, we have carried out atomistic-scale computer simulations (totaling 2.65 µs) to investigate the behavior of Aβ monomer and dimers in GM1-containing raft-like membrane. The oligosaccharide head-group of GM1 was observed to act as scaffold for Aβ-binding through sugar-specific interactions. Starting from the initial helical peptide conformation, a β-hairpin motif was formed at the C-terminus of the GM1-bound Aβ-monomer; that didn’t appear in absence of GM1 (both in fluid POPC and liquid-ordered cholesterol/POPC bilayers and also in aqueous medium) within the simulation time span. For Aβ-dimers, the β-structure was further enhanced by peptide-peptide interactions, which might influence the propensity of Aβ to aggregate into higher-ordered structures. The salt-bridges and inter-peptide hydrogen bonds were found to account for dimer stability. We observed spontaneous formation of intra-peptide D23-K28 salt-bridge and a turn at V24GSN27 region - long been accepted as characteristic structural-motifs for amyloid self-assembly. Altogether, our results provide atomistic details of Aβ-GM1 and Aβ-Aβ interactions and demonstrate their importance in the early-stages of GM1-mediated Aβ-oligomerisation on membrane surface.
Unful fi lled expectations and symptoms of depression among young adults

This study uses the life course perspective and data from 16 waves of the US National Longitudinal Survey of Youth (1979e1994) to examine whether unfulfilled expectations about educational attainment, employment, marriage, and parenthood are risk factors for subsequent symptoms of depression among young adults in the United States. Results from ordinary least squares regression analyses indicate that achieving a lower level of education than expected, becoming a parent unexpectedly, and being out of the labor force unexpectedly at ages 19e27 predict higher levels of depressive symptoms at ages 29e37, adjusting for demographics, family background, and earlier mental health. These effects do not significantly vary by gender, age, race/ethnicity, or family background, and are not explained by being selected out of the labor force for long durations because of mental or physical illness, attending school, keeping house, or other reasons. Overall, this study contributes to the literature on stress and mental health by acknowledging people’s expectations about the markers of adulthood, and advances our understanding of why the timing of transitions in people’s lives can have long-term mental health consequences. 2011 Elsevier Ltd. All rights reserved. “To say that we are architects of our lives is not to say that our lives turn out as we intended. ” (Gecas, 2003, p. 384)
Targeting the BMK1 MAP Kinase Pathway in Cancer Therapy

The big mitogen activated protein kinase 1 (BMK1) pathway is the most recently discovered and least-studied mammalian mitogen-activated protein (MAP) kinase cascade, ubiquitously expressed in all types of cancer cells tested so far. Mitogens and oncogenic signals strongly activate this cellular MAP kinase pathway, thereby passing down proliferative, survival, chemoresistance, invasive, and angiogenic signals in tumor cells. Recently, several pharmacologic small molecule inhibitors of this pathway have been developed. Among them, the BMK1 inhibitor XMD8–92 blocks cellular BMK1 activation and significantly suppresses tumor growth in lung and cervical tumor models and is well tolerated in animals. On the other hand, MEK5 inhibitors, BIX02188, BIX02189, and compound 6, suppress cellular MEK5 activity, but no data exist to date on their effectiveness in animals. Clin Cancer Res; 17(11); 3527–32. ©2011 AACR.
ATP-driven MalK Dimer Closure and Reopening and Conformational Changes of the “EAA” Motifs Are Crucial for Function of the Maltose ATP-binding Cassette Transporter (MalFGK2)*

We have investigated conformational changes of the purified maltose ATP-binding cassette transporter (MalFGK2) upon binding of ATP. The transport complex is composed of a heterodimer of the hydrophobic subunits MalF and MalG constituting the translocation pore and of a homodimer of MalK, representing the ATP-hydrolyzing subunit. Substrate is delivered to the transporter in complex with periplasmic maltose-binding protein (MalE). Cross-linking experiments with a variant containing an A85C mutation within the Q-loop of each MalK monomer indicated an ATP-induced shortening of the distance between both monomers. Cross-linking caused a substantial inhibition of MalE-maltose-stimulated ATPase activity. We further demonstrated that a mutation affecting the “catalytic carboxylate” (E159Q) locks the MalK dimer in the closed state, whereas a transporter containing the “ABC signature” mutation Q140K permanently resides in the resting state. Cross-linking experiments with variants containing the A85C mutation combined with cysteine substitutions in the conserved EAA motifs of MalF and MalG, respectively, revealed close proximity of these residues in the resting state. The formation of a MalK-MalG heterodimer remained unchanged upon the addition of ATP, indicating that MalG-EAA moves along with MalK during dimer closure. In contrast, the yield of MalK-MalF dimers was substantially reduced. This might be taken as further evidence for asymmetric functions of both EAA motifs. Cross-linking also caused inhibition of ATPase activity, suggesting that transporter function requires conformational changes of both EAA motifs. Together, our data support ATP-driven MalK dimer closure and reopening as crucial steps in the translocation cycle of the intact maltose transporter and are discussed with respect to a current model.
International Journal of C 2004 Institute for Scientific Numerical Analysis and Modeling Computing and Information a New Perspective on Texture Evolution

Modeling and analysis of texture evolution in polycrystalline materials is a major challenge in materials science. It requires understanding grain boundary or interface evolution at the network level, where topologi-cal reconfigurations (critical events) play an important role. In this paper, we investigate grain boundary evolution in a simplified one-dimensional system designed specifically to target microstructural critical event evolution. We suggest a stochastic framework that may be used to model this system and compare predictions of the model with simulations. We discuss limitations and possible extensions of this approach to higher-dimensional cases.
Electrochemical electron beam lithography: Write, read, and erase metallic nanocrystals on demand

We develop an electrochemistry- and radiolysis-based patterning technique for site-specific deposition and dissolution of metallic nanocrystals. We develop a solution-based nanoscale patterning technique for site-specific deposition and dissolution of metallic nanocrystals. Nanocrystals are grown at desired locations by electron beam–induced reduction of metal ions in solution, with the ions supplied by dissolution of a nearby electrode via an applied potential. The nanocrystals can be “erased” by choice of beam conditions and regrown repeatably. We demonstrate these processes via in situ transmission electron microscopy using Au as the model material and extend to other metals. We anticipate that this approach can be used to deposit multicomponent alloys and core-shell nanostructures with nanoscale spatial and compositional resolutions for a variety of possible applications.
Pharmacologic Treatment of Repetitive Behaviors in Autism Spectrum Disorders: Evidence of Publication Bias

OBJECTIVE: The goal of this study was to examine the efficacy of serotonin receptor inhibitors (SRIs) for the treatment of repetitive behaviors in autism spectrum disorders (ASD). METHODS: Two reviewers searched PubMed and Clinicaltrials.gov for randomized, double-blind, placebo-controlled trials evaluating the efficacy of SRIs for repetitive behaviors in ASD. Our primary outcome was mean improvement in ratings scales of repetitive behavior. Publication bias was assessed by using a funnel plot, the Egger’s test, and a meta-regression of sample size and effect size. RESULTS: Our search identified 5 published and 5 unpublished but completed trials eligible for meta-analysis. Meta-analysis of 5 published and 1 unpublished trial (which provided data) demonstrated a small but significant effect of SRI for the treatment of repetitive behaviors in ASD (standardized mean difference: 0.22 [95% confidence interval: 0.07–0.37], z score = 2.87, P < .005). There was significant evidence of publication bias in all analyses. When Duval and Tweedie's trim and fill method was used to adjust for the effect of publication bias, there was no longer a significant benefit of SRI for the treatment of repetitive behaviors in ASD (standardized mean difference: 0.12 [95% confidence interval: –0.02 to 0.27]). Secondary analyses demonstrated no significant effect of type of medication, patient age, method of analysis, trial design, or trial duration on reported SRI efficacy. CONCLUSIONS: Meta-analysis of the published literature suggests a small but significant effect of SRI in the treatment of repetitive behaviors in ASD. This effect may be attributable to selective publication of trial results. Without timely, transparent, and complete disclosure of trial results, it remains difficult to determine the efficacy of available medications.
Spin Chains in \ ( \ mathcal { N } \ ) = 6

In this note we study spin chain operators in the N = 6 Chern-Simons-matter theory recently proposed by Aharony, Bergman, Jafferis and Maldacena to be dual to type IIA string theory in AdS4 ×CP. We study the two-loop dilatation operator in the gauge theory, and compare to the Penrose limit on the string theory side.
Influence of Gravity Field and Rotation on a Generalized Thermoelastic Medium using a Dual-Phase-Lag Model

 Abstract— In the present paper, The normal mode analysis is used to study the deformation of a rotating generalized thermoelastic medium under the influence of gravity subjected to thermal loading in the context of dual-phase-lag thermoelastic model. The exact expressions for the temperature, displacement components, and stress components are given in the physical domain and illustrated graphically. These expressions are calculated numerically for the problem. Comparisons are made with the results predicted by Lord-Shulman theory and dual-phase-lag model in the presence and absence of rotation as well as gravity.
Antifungal properties of dairy propionibacteria

Today global agriculture is facing major challenges. The world's population is growing rapidly and we need to meet the increasing need for food with new strategies, including environmentally sustainable practices. Production must be enhanced with optimised resource utilisation and improved storage and distribution techniques. In addition, consumer demands for a reduction in artificial preservatives require innovative research thinking. The use of microorganisms as biopreservatives has many advantages. They often originate from environments similar to those where they will be used, making their presence natural. Bacteria such as lactic acid bacteria and dairy propionibacteria produce weak organic acids with good preserving capacity and several other antimicrobial compounds. Dairy propionibacteria possess additional advantageous features such as high production of vitamin b₁₂ and folic acid. Some strains also produce exopolysaccharides, useful for texture enhancement in dairy products. This thesis focuses on the antifungal properties of dairy propionibacteria. An important part of their antifungal capacity is due to the production of organic acids. The effect of these acids at different ph and different concentrations against eight spoilage fungi was investigated. A ph-dependent growth inhibition effect was detected, with Penicillium roqueforti being the most sensitive fungal species. In addition, dairy propionibacteria produce a number of other compounds with antifungal activity. Identification of 3-phenyl lactic acid and several antifungal peptides present in the growth medium was made after separation with a solid phase extraction column and hplc. The antifungal activity was monitored by screening against Aspergillus fumigatus. Strong enhancement of the antifungal activity from dairy propionibacteria in combination with glycerol was demonstrated. Addition of 500 mm glycerol to the upper layer in an overlay assay reduced the growth of some spoilage fungi completely. An antifungal strain of Propionibacterium jensenii was combined with Lactobacillus fermentum in a biopreserving culture used in moist grain preservation. The addition of glycerol to the system enhanced production of propionic acid in some cases, and an earlier decline in ph was detected. However, this combination of bacteria was not able to reduce the growth of P. roqueforti.
Metallurgical aspects of rock bolt environmental fracture

The aim of this research was to understand the Stress Corrosion Cracking (SCC) of rock bolts. The laboratory tests have produced fracture surfaces similar to those from service. The experimental study elucidated the environmental condition leading to rock bolt SCC, and was used to determine the threshold stress and the threshold potential. A hydrogen embrittlement mechanism is proposed.
Newt Myotubes Reenter the Cell Cycle by Phosphorylation of the Retinoblastoma Protein

Withdrawal from the cell cycle is an essential aspect of vertebrate muscle differentiation and requires the retinoblastoma (Rb) protein that inhibits expression of genes needed for cell cycle entry. It was shown recently that cultured myotubes derived from the Rb−/−mouse reenter the cell cycle after serum stimulation (Schneider, J.W., W. Gu, L. Zhu, V. Mahdavi, and B. Nadal-Ginard. 1994. Science (Wash. DC). 264:1467– 1471). In contrast with other vertebrates, adult urodele amphibians such as the newt can regenerate their limbs, a process involving cell cycle reentry and local reversal of differentiation. Here we show that myotubes formed in culture from newt limb cells are refractory to several growth factors, but they undergo S phase after serum stimulation and accumulate 4N nuclei. This response to serum is inhibited by contact with mononucleate cells. Despite the phenotypic parallel with Rb−/− mouse myotubes, Rb is expressed in the newt myotubes, and its phosphorylation via cyclin-dependent kinase 4/6 is required for cell cycle reentry. Thus, the postmitotic arrest of urodele myotubes, although intact in certain respects, can be undermined by a pathway that is inactive in other vertebrates. This may be important for the regenerative ability of these animals.
Evaluation of White Matter Abnormality in Mild Alzheimer Disease and Mild Cognitive Impairment Using Diffusion Tensor Imaging: A Comparison of Tract-Based Spatial Statistics with Voxel-Based Morphometry

Purpose : To evaluate white matter abnormalities on diffusion tensor imaging (DTI) in patients with mild Alzheimer disease (AD) and mild cognitive impairment (MCI), using tract-based spatial statistics (TBSS) and voxel-based morphometry (VBM). Materials and Methods: DTI was performed in 21 patients with mild AD, in 13 with MCI and in 16 old healthy subjects. A fractional anisotropy (FA) map was generated for each participant and processed for voxel-based comparisons among the three groups using TBSS. For comparison, DTI data was processed using the VBM method, also. Results: TBSS showed that FA was significantly lower in the AD than in the old healthy group in the bilateral anterior and right posterior corona radiata, the posterior thalamic radiation, the right superior longitudinal fasciculus, the body of the corpus callosum, and the right precuneus gyrus. VBM identified additional areas of reduced FA, including both uncinates, the left parahippocampal white matter, and the right cingulum. There were no significant differences in FA between the AD and MCI groups, or between the MCI and old healthy groups. Conclusion: TBSS showed multifocal abnormalities in white matter integrity in patients with AD compared with old healthy group. VBM could detect more white matter lesions than TBSS, but with increased artifacts.