Miracle-dz/UniFAR-FTUs huggingface dataset:
Major histocompatibility antigens and antigen-processing molecules in uveal melanoma.

PURPOSE Malignant transformation of cells is frequently associated with abnormalities in the human leukocyte antigen (HLA) expression. These abnormalities may play a role in the clinical course of the disease, because HLA antigens mediate interactions of tumor cells with T cells and natural killer cells. Uveal melanoma is a highly malignant tumor of the eye and is characterized by hematogenic spread to liver. Antigen-processing molecules (APMs) are necessary for efficient expression of HLA class I antigens. We studied the expression of HLA antigens and the APM in uveal melanomas by immunohistochemistry and correlated clinicopathologically. EXPERIMENTAL DESIGN HLA class I antigen, beta(2)-microglobulin (beta(2)-m), HLA class II antigens, and the APM comprising proteasomal subunits low molecular mass polypeptide (LMP) 2, beta-subunit of LMP2-Delta, LMP 10, transporter associated protein 1 subunit, and chaperone molecules tapasin and calnexin were studied in 41 primary uveal melanoma archival specimens by immunohistochemistry. Immunoanalysis was done by a semiquantitative method and correlated with extrascleral extension, cell types, and the largest tumor diameter. RESULTS HLA class I antigen, beta(2)-m, HLA class II antigen, and the APM were decreased (negative staining in 29 tumors and dull staining in 3 tumors) in 100% (32 of 32) uveal melanomas with no extrascleral extension. (P = 0.01) and positive (bright staining) in 67% (4 of 9) tumors with liver metastasis. Decreased immunoexpression of HLA antigens and the APM was seen in nonepithelioid cell melanomas. There was no correlation with largest tumor diameter. CONCLUSIONS Our data suggest decreased expression of HLA, and APM are seen in uveal melanomas with no extrascleral extension and in nonepithelioid cell melanomas. Decreased expression of APM may contribute to decreased HLA class I antigen expression.
Implementasi Kepemimpinan Transformasional Kepala Sekolah dalam Meningkatkan Mutu Sekolah di SD Kanisius Sengkan, Kabupaten Sleman

Penelitian ini bertujuan untuk mengungkapkan implementasi kepemimpinan transformasional kepala sekolah dalam meningkatkan mutu sekolah SD Kanisius Sengkan, Kabupaten Sleman. Penelitian ini merupakan penelitian kualitatif dengan jenis penelitian studi kasus. Pengumpulan data menggunakan metode kajian dokumen, observasi, dan wawancara. Analisis data menggunakan analisis model interaktif dari Miles dan Huberman yang meliputi empat tahap analisis yaitu: pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa kepemimpinan transformasional kepala sekolah SD Kanisius Sengkan mampu menciptakan perubahan dan membawa SD Kanisius mencapai prestasi yang baik. Kepala sekolah menjadi tokoh panutan yang dihormati, dihargai, dan dipercaya. Kepala sekolah mampu membangun semangat kebersamaan dan kedisiplinan serta memotivasi para guru dan karyawan untuk bekerja secara optimal. Kepala sekolah berani melakukan perubahan melalui tindakan-tindakan yang kreatif dan inovatif. Akhirnya kepala sekolah mampu membangun kesadaran berorganisasi pada para guru dan karyawan dengan mengembangkan sikap rasa memiliki dan rasa bertanggung jawab untuk meraih prestasi setinggi-tingginya. Kata kunci: kepala sekolah, kepemimpian transformasional, mutu sekolah.
CULTURAL IMPACT ON THE DESIGN OF E-COMMERCE WEBSITES: Part I - Site Format and Layout

How to “think globally, act locally” is a challenge facing many e-commerce companies that want to extend their business to other parts of the globe. To address the cultural dimension of this problem, this paper examines a selection of leading e-commerce websites from the United States and China to determine what impact do cultural differences have on the format and layout of their design. The implications of cultural influences on website design are discussed.
ANATOMIC ASYMMETRY IN THE TEMPORAL LOBES: ITS DOCUMENTATION, PHYLOGENESIS, AND RELATIONSHIP TO FUNCTIONAL ASYMMETRY *

There has been a recent surge in the number of studies indicating anatomic asymmetry in the posterior regions of the temporal lobes of the brain. This neural asymmetry was first observed for human adults, then for human infants and, most recently, for nonhuman primates. This evidence will be reviewed. The implications of the existence of such neuroanatomic asymmetry in nonlinguistic animals will be discussed in terms of the possible role the evolution of anatomic asymmetry may have for the phylogenetic development of cognition and the light it may shed on the nature of functional asymmetry of the hemispheres in man. The precautions for considering the anatomic asymmetry as a substrate for functional asymmetry will be indicated.
cGMP-Dependent Kinase Regulates Response Sensitivity of the Mouse On Bipolar Cell

The visual system can adjust its sensitivity over a wide range of light intensities. Photoreceptors account for some of this adjustment, but there is evidence that postreceptoral processes also exist. To investigate the latter, we pharmacologically mimicked the effects of light stimulation on mouse On bipolar cells, thus avoiding confounding effects of receptoral mechanisms. Here, we report that cGMP selectively enhances responses to dim, but not bright, stimuli through a purely postsynaptic mechanism. This action of cGMP was completely blocked by inhibitors of cGMP-dependent kinase. We propose that cGMP-dependent kinase decreases coupling of the On bipolar cell glutamate receptor to the downstream cascade, thus amplifying small decreases in photoreceptor transmitter levels that would otherwise go undetected by the visual system.
Association of serum cytokines with colorectal polyp number and type in adult males

Chronic inflammation contributes to colorectal carcinogenesis. To determine whether serum cytokines are associated with colon polyps, 126 asymptomatic men (48–65 years) were recruited during colonoscopy. Serum cytokine concentrations were measured. Odds ratios were determined using polytomous logistic regression for polyp number and type. Men with serum monocyte chemotactic protein-3 (MCP-3) or soluble interleukin-4 receptor (sIL-4R) concentrations in the highest tertile were 0.2 times less likely to have three or more polyps relative to no polyps. For each increase in serum MCP-3 or sIL-4R tertile a man was about 0.4 times less likely to have three or more polyps than to have no polyps. Men with serum concentrations of interferon-&agr;2 (IFN-&agr;2) or interleukin (IL)-7 in the highest tertile were three times more likely to have an adenoma than no polyps. Those with serum IL-8 concentrations in the highest tertile were four times more likely to have an adenoma than no polyps. For each increase in serum IFN-&agr;2, IL-7, or IL-8 tertile an individual was 1.8 times more likely to have an adenoma than to have no polyps. Serum concentrations of MCP-3, sIL-4R, IFN-&agr;2, IL-7, and IL-8 may indicate which men are more likely to have colorectal polyps.
Arterial Stiffness Is Associated With Cardiovascular, Renal, Retinal, and Autonomic Disease in Type 1 Diabetes

OBJECTIVE In patients with type 1 diabetes, we investigated the association between arterial stiffness and diabetes complications. RESEARCH DESIGN AND METHODS This was a cross-sectional study including 676 Caucasian patients with type 1 diabetes (374 [55%] men, aged 54 ± 13 years [mean ± SD]) and 51 nondiabetic controls (28 [55%] men, aged 47 ± 13 years). Aortic pulse wave velocity (PWV) was measured with SphygmoCor (AtCor Medical, Sydney, Australia) for 635 patients and all 51 controls. RESULTS PWVs (mean ± SD) in patients and controls were 10.4 ± 3.4 and 7.6 ± 1.9 m/s, respectively (P < 0.001). After multivariate adjustment, PWV correlated with age, diabetes duration, urinary albumin excretion rate, heart rate, and blood pressure (P < 0.05 for all). ANCOVA was used for comparisons between groups and adjusted for gender, age, estimated glomerular filtration rate, heart rate, HbA1c, and 24-h mean arterial pressure. PWVs in normoalbuminuric, microalbuminuric, and macroalbuminuric patients were 9.5 ± 3.2, 11.0 ± 3.6, and 11.4 ± 3.0 m/s, respectively (adjusted P < 0.001). PWV in patients with previous cardiovascular disease, versus patients without, was 12.1 ± 3.5 vs. 10.0 ± 3.2 m/s, respectively (adjusted P < 0.001). PWVs in patients with high (≥140/90 mmHg) versus intermediate (130–40/80–89 mmHg) and low (<130/80 mmHg) blood pressure were 11.8 ± 3.6, 10.0 ± 3.0, and 9.8 ± 3.3 m/s, respectively (adjusted P < 0.001). Furthermore, PWV increased with increasing degree of retinopathy: 8.0 ± 2.5 m/s (nil), 10.0 ± 2.8 m/s (simplex), 12.1 ± 3.5 m/s (proliferative), and 12.7 ± 2.4 m/s (blind), respectively (adjusted P < 0.001). Finally, PWV increased with abnormal heart rate variability: 11.5 ± 3.3 m/s vs. 10.1 ± 3.1 m/s (borderline) and 8.1 ± 2.1 m/s (normal) (adjusted P = 0.027). CONCLUSIONS Arterial stiffness increased with presence and duration of type 1 diabetes. Furthermore, PWV increased with all the investigated diabetes complications (cardiovascular, renal, retinal, and autonomic disease) independently of other risk factors.
État de stress post-traumatique comorbide, facteurs de risque et de protection parmi des individus itinérants en traitement pour des troubles liés à l’utilisation de substances

Few studies explored the frequencies of trauma and of posttraumatic stress disorder (PTSD) among homeless individuals and especially, among those being treated for substance use disorders (SUD). The main objective of the study was to measure the frequencies of traumas and potential PTSD diagnosis among clients being treated for SUD in Montreal. The other objective was to verify differences between those with or without a potential PTSD diagnosis. The sample consisted of 51 homeless individuals, 9 women and 42 men. The mean age was 46 years (SD = 7.19). Participants experienced in average 4.24 (SD = 2.06) trauma types. 49% of the sample had a potential PTSD diagnosis. Most participants had: an alcoholic parent, experience an early trauma and little social support. The participants who had a potential PTSD diagnosis: had an alcoholic parent, experienced an early trauma, and significantly used more maladaptive coping strategies.
Morphology-aware statistical machine translation based on morphs induced in an unsupervised manner

In this paper, we apply a method of unsupervised morphology learning to a state-of-the-art phrase-based statistical ma chine translation (SMT) system. In SMT, words are traditionally used as the smallest units of translation. Such a system generalizes poorl y to word forms that do not occur in the training data. In particular, this is problematic for languages that are highly compounding, highly inflecting, or both. An alternative way is to use sub-word units, such as morphemes. We use the Morfessor algorithm to find statistical mo rphemelike units (called morphs) that can be used to reduce the size of the lexicon and improve the ability to generalize. Transl ation and language models are trained directly on morphs instead of words. The approach is tested on three Nordic languages (Danish, Finnish, and Swedish) that are included in the Europarl corpus consisting of the Proceedings of the European Parliament. However, in our experiments we did not obtain higher BLEU scores for the morph model than for the standard word-based approach. Nonetheless, the proposed morph-based solution has clear benefits, as morpho logically well motivated structures (phrases) are learned , and the proportion of words left untranslated is clearly reduced.
Re‐envisioning the Future: Democratic Citizenship Education and Islamic Education

In this article we address the issue of why democratic citizenship education should be incorporated more meaningfully into Islamic education discourses in formal institutions in the Arab and Muslim world. In the Arab and Muslim world civic and national education seem to be the dominant discourses. We argue that the latter discourses are inadequate to address some of the dystopias in the Arab and Muslim world such as the perpetuation of patriarchy, uncritical obedience to the state (often dictatorships), and blind patriotism. Consequently we posit that unless a culture of acceptance and hospitality (i.e. cosmopolitanism) is cultivated at Islamic educational institutions the possibility of democratic citizenship education unfolding is quite remote. That is, the future of Islamic education can only be re-envisioned if an amended version of democratic citizenship education can inform Islamic education discourses in institutions—one constituted by a culture of acceptance and hospitality.
Molecular characterization of a gene encoding juvenile hormone esterase in the red flour beetle, Tribolium castaneum

Juvenile hormone esterases (JHEs) are required for the degradation of juvenile hormones (JHs) in insects. Here, we report the cloning and analysis of the jhe gene in the red flour beetle, Tribolium castaneum, a model insect of Coleoptera. The Tcjhe gene was strongly expressed at the final instar larva, as would be expected if it functioned to decrease the JH titer at this stage. A recombinant TcJHE protein efficiently degraded JH III, suggesting that the enzyme functions in vivo as a JH‐specific degradation enzyme. This is the first report describing the developmental expression profile of the jhe gene whose enzymatic activity was shown in Coleoptera, and the new data reported here will aid elucidation of the mechanism of JH titer regulation in insects.
Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid*

The recent identification of the Vzg-1/Edg2 protein as a functional G protein-coupled receptor for lysophosphatidic acid (LPA) has allowed a sequence-based search for new genes that may encode novel subtypes of LPA receptors. A human cDNA encoding a G protein-coupled receptor, designated Edg4, was identified by searching the GenBank™ for homologs of the human Edg2 LPA receptor. The Edg4 protein is 46% identical and 72% similar in amino acid sequence to human Edg2. When overexpressed in Jurkat T cells, the Edg4 protein mediated LPA-induced activation of a serum response element reporter gene with LPA concentration dependence (EC50 of 10 nm) and specificity. This LPA-induced reporter gene activation could be partially inhibited by pretreatment with pertussis toxin or C3 exoenzyme, suggesting requirements for both a Gi protein and Rho GTPase. Overexpression of Edg4 in Jurkat cells also led to increases in specific binding sites for [3H]LPA. Northern blots revealed that twoedg4 mRNA transcripts of 1.8 and 8 kilobases are distributed very differently from edg2 mRNAs in adult human tissues and several cancer cell lines. The existence and distinctive tissue expression of structurally different subtypes of LPA receptors may provide one basis for tissue-specific functions and permit independent regulation of each subtype of LPA receptor.
The effects of state anxiety on the suggestibility and accuracy of child eyewitnesses

The negative effect of misleading information on memory is a well-established fact in eyewitness testimony. However, individual differences have rarely been studied in this context, particularly in children. This paper is one of the first to explore whether objectively measured state anxiety levels have a moderating influence on suggestibility. A group of 83 9–10-year-old schoolchildren took part in the experiment. They were tested on their recall of details surrounding a minor car accident shown on video. No effects of state anxiety on accuracy were found. Clear misleading information effects were found, however (p < 0.001). Furthermore, both analysis of covariance and Pearson's correlation coefficients showed that higher anxiety levels were associated with a reduction in the number of misled responses given by the misinformed participants relative to low-anxious participants (p < 0.05). The theoretical relevance of these findings are discussed in the light of processing efficiency theory and the ‘affect as information’ hypothesis. The practical implications for children as witnesses are also considered. Copyright © 2002 John Wiley & Sons, Ltd.
Modeling and forecasting persistent financial durations

ABSTRACT This article introduces the Markov-Switching Multifractal Duration (MSMD) model by adapting the MSM stochastic volatility model of Calvet and Fisher (2004) to the duration setting. Although the MSMD process is exponential β-mixing as we show in the article, it is capable of generating highly persistent autocorrelation. We study, analytically and by simulation, how this feature of durations generated by the MSMD process propagates to counts and realized volatility. We employ a quasi-maximum likelihood estimator of the MSMD parameters based on the Whittle approximation and establish its strong consistency and asymptotic normality for general MSMD specifications. We show that the Whittle estimation is a computationally simple and fast alternative to maximum likelihood. Finally, we compare the performance of the MSMD model with competing short- and long-memory duration models in an out-of-sample forecasting exercise based on price durations of three major foreign exchange futures contracts. The results of the comparison show that the MSMD and the Long Memory Stochastic Duration model perform similarly and are superior to the short-memory Autoregressive Conditional Duration models.
Evolutionary history influences the salinity preference of bacterial taxa in wetland soils

Salinity is a major driver of bacterial community composition across the globe. Despite growing recognition that different bacterial species are present or active at different salinities, the mechanisms by which salinity structures community composition remain unclear. We tested the hypothesis that these patterns reflect ecological coherence in the salinity preferences of phylogenetic groups using a reciprocal transplant experiment of fresh- and saltwater wetland soils. The salinity of both the origin and host environments affected community composition (16S rRNA gene sequences) and activity (CO2 and CH4 production, and extracellular enzyme activity). These changes in community composition and activity rates were strongly correlated, which suggests the effect of environment on function could be mediated, at least in part, by microbial community composition. Based on their distribution across treatments, each phylotype was categorized as having a salinity preference (freshwater, saltwater, or none) and phylogenetic analyses revealed a significant influence of evolutionary history on these groupings. This finding was corroborated by examining the salinity preferences of high-level taxonomic groups. For instance, we found that the majority of α- and γ-proteobacteria in these wetland soils preferred saltwater, while many β-proteobacteria prefer freshwater. Overall, our results indicate the effect of salinity on bacterial community composition results from phylogenetically-clustered salinity preferences.
Comparative oligonucleotide sequences of 28 S ribosomal RNA normal liver and Novikoff hepatoma ascites cells.

Summary The distributions and structures of complete pancreatic RNase digestion products of 28 S rRNA were compared for the Novikoff hepatoma and rat liver. The oligonucleotides of the digests were separated on diethylaminoethyl Sephadex A-25 at pH 7.6 according to chain length, and the mono-, di-, octa-, nona-, and decanucleotides were compared separately after isolation of the single components by paper electrophoresis at pH 3.5 (mono- and dinucleotides) or by rechromatography on diethylaminoethyl Sephadex A-25 at pH 3.3 (octa-, nona-, and decanucleotides). On the basis of a calculated chain length of 4500 for 28 S rRNA, the frequencies of the mono- and dinucleotides were defined; they differed mainly in the dinucleotide G-Up, which occurs 134 and 103 times in 28 S rRNA of the Novikoff hepatoma and rat liver, respectively. The polypurine sequences G-A-G-G-A-A-G-Cp, A-A-A-A-G-G-A-A-Cp, A-G-A-G-G-A-A-A-Cp, and G-G-G-A-A-G-A-G-Up, and the partial sequences of a number of other octa-, nona-, and decanucleotides were found in both the 28 S rRNA of rat liver and of the Novikoff hepatoma. They were identified by their positions in the elution profiles of the subfractionations on diethylaminoethyl Sephadex A-25 at pH 3.3 and by their compositions as determined after complete digestion with T 1 RNase.
graph2vec: Learning Distributed Representations of Graphs

Recent works on representation learning for graph structured data predominantly focus on learning distributed representations of graph substructures such as nodes and subgraphs. However, many graph analytics tasks such as graph classification and clustering require representing entire graphs as fixed length feature vectors. While the aforementioned approaches are naturally unequipped to learn such representations, graph kernels remain as the most effective way of obtaining them. However, these graph kernels use handcrafted features (e.g., shortest paths, graphlets, etc.) and hence are hampered by problems such as poor generalization. To address this limitation, in this work, we propose a neural embedding framework named graph2vec to learn data-driven distributed representations of arbitrary sized graphs. graph2vec's embeddings are learnt in an unsupervised manner and are task agnostic. Hence, they could be used for any downstream task such as graph classification, clustering and even seeding supervised representation learning approaches. Our experiments on several benchmark and large real-world datasets show that graph2vec achieves significant improvements in classification and clustering accuracies over substructure representation learning approaches and are competitive with state-of-the-art graph kernels.
Survival Benefit of Zoledronic Acid in Postmenopausal Breast Cancer Patients Receiving Aromatase Inhibitors

Purpose A growing body of evidence indicates that zoledronic acid (ZA) can improve the clinical outcome in patients with breast cancer and low estrogen levels. In the present study, we aimed to investigate the survival benefit of ZA administration in postmenopausal Korean women with breast cancer who were also receiving aromatase inhibitors. Methods Between January 2004 and December 2010, 235 postmenopausal breast cancer patients undergoing aromatase inhibitor therapy were investigated. All patients were postmenopausal, as confirmed by laboratory tests. Of these patients, 77 received adjuvant upfront ZA for at least 1 year in addition to conventional adjuvant treatment. The remaining 158 patients never received ZA and were treated according to the St. Gallen guidelines. Results The baseline characteristics for ZA treatment were not different between the two groups. The median follow-up time was 62 months, and the patients who received ZA in addition to aromatase inhibitors showed a better recurrence-free survival compared to those who received aromatase inhibitors alone (p=0.035). On multivariate analysis, the patients who received ZA showed a better recurrence-free survival independent of the tumor size, nodal status, progesterone receptor, and histological grade. For this model, Harrell c index was 0.743. The hazard ratio of ZA use for recurrence-free survival was 0.12 (95% confidence interval, 0.01-0.99). Conclusion Our findings suggest that upfront use of ZA as part of adjuvant treatment can offer a survival benefit to postmenopausal breast cancer patients receiving aromatase inhibitor treatment.