Miracle-dz/UniFAR-FTUs huggingface dataset:
Gonadotrophic control of steroidogenesis in human granulosa-lutein cells.

Granulosa-lutein cells were harvested from periovulatory follicles in human ovaries and cultured for up to 6 days, equivalent to almost half of a normal luteal phase. The average rate of basal progesterone accumulation in the culture medium was constant at approximately 36 nmol progesterone/10(6) cells/day. Oestradiol accumulation was too low to measure in the absence of precursor androgen. Basal aromatase activity (measured as oestradiol formed in 3 h from 10(-6) M exogenous testosterone) was high (average 1.15 nmol oestradiol/10(6) cells/3 h) at the time of cell isolation (Day 0) but fell by greater than 90% on Day 1. By Day 2 the activity had partly recovered and averaged 62% of the Day 0 value, rising to 70% on Day 6. This loss and recovery of aromatase activity was independent of the addition of gonadotrophic hormones to the culture medium. However, dose-related increases in aromatase activity occurred in the presence of highly pure human pituitary LH (0.1-30 ng/ml). The increase was observed on Day 4 and was maximal on Day 6 (average 3-fold increase over control) in the presence of LH concentrations greater than or equal to 1.0 ng/ml. LH also caused dose-related increases in progesterone accumulation by Day 4 with maximal stimulation on Day 6 (average 3-fold increase over control) at greater than or equal to 10.0 ng/ml. Dose-related stimulation of aromatase activity by human pituitary FSH also occurred but maximal stimulation required the presence of 300 ng FSH/ml and progesterone accumulation was hardly affected at this dose. (ABSTRACT TRUNCATED AT 250 WORDS)
Cyclohexa-1,5-Diene-1-Carbonyl-Coenzyme A (CoA) Hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a Common Benzoyl-CoA Degradation Pathway in Facultative and Strict Anaerobes

ABSTRACT In the denitrifying bacterium Thauera aromatica, the central intermediate of anaerobic aromatic metabolism, benzoyl-coenzyme A (CoA), is dearomatized by the ATP-dependent benzoyl-CoA reductase to cyclohexa-1,5-diene-1-carbonyl-CoA (dienoyl-CoA). The dienoyl-CoA is further metabolized by a series of β-oxidation-like reactions of the so-called benzoyl-CoA degradation pathway resulting in ring cleavage. Recently, evidence was obtained that obligately anaerobic bacteria that use aromatic growth substrates do not contain an ATP-dependent benzoyl-CoA reductase. In these bacteria, the reactions involved in dearomatization and cleavage of the aromatic ring have not been shown, so far. In this work, a characteristic enzymatic step of the benzoyl-CoA pathway in obligate anaerobes was demonstrated and characterized. Dienoyl-CoA hydratase activities were determined in extracts of Geobacter metallireducens (iron reducing), Syntrophus aciditrophicus (fermenting), and Desulfococcus multivorans (sulfate reducing) cells grown with benzoate. The benzoate-induced genes putatively coding for the dienoyl-CoA hydratases in the benzoate degraders G. metallireducens and S. aciditrophicus were heterologously expressed and characterized. Both gene products specifically catalyzed the reversible hydration of dienoyl-CoA to 6-hydroxycyclohexenoyl-CoA (Km , 80 and 35 μM; V max, 350 and 550 μmol min−1 mg−1, respectively). Neither enzyme had significant activity with cyclohex-1-ene-1-carbonyl-CoA or crotonyl-CoA. The results suggest that benzoyl-CoA degradation proceeds via dienoyl-CoA and 6-hydroxycyclohexanoyl-CoA in strictly anaerobic bacteria. The steps involved in dienoyl-CoA metabolism appear identical in all nonphotosynthetic anaerobic bacteria, although totally different benzene ring-dearomatizing enzymes are present in facultative and obligate anaerobes.
Measurement-Based Analysis, Modeling, and Synthesis of the Internet Delay Space

Understanding the characteristics of the Internet delay space (i.e., the all-pairs set of static round-trip propagation delays among edge networks in the Internet) is important for the design of global-scale distributed systems. For instance, algorithms used in overlay networks are often sensitive to violations of the triangle inequality and to the growth properties within the Internet delay space. Since designers of distributed systems often rely on simulation and emulation to study design alternatives, they need a realistic model of the Internet delay space. In this paper, we analyze measured delay spaces among thousands of Internet edge networks and quantify key properties that are important for distributed system design. Our analysis shows that existing delay space models do not adequately capture these important properties of the Internet delay space. Furthermore, we derive a simple model of the Internet delay space based on our analytical findings. This model preserves the relevant metrics far better than existing models, allows for a compact representation, and can be used to synthesize delay data for simulations and emulations at a scale where direct measurement and storage are impractical. We present the design of a publicly available delay space synthesizer tool called DS 2 and demonstrate its effectiveness.
A 6-Item Family Resilience Scale (FRS6) for Measuring Longitudinal Trajectory of Family Adjustment

Two studies were conducted in Hong Kong to validate a brief measure of family resilience based on the three-factor CPR model. The CPR model stipulates that family resilience comprises three major factors: Communication and Connectedness (C), Positive Framing (P), and External Resources (R). Study 1 abbreviated the 16-item Family Resilience Scale (FRS16) into six items (FRS6) with a parent sample in the community (N = 1270). Study 2 tested the validity of the FRS6 with a single parent sample (N = 336). The result of Study 1 suggests a dominant general family resilience factor structure with three distinct subfactors. The highest factor loading items from each of the three subfactors were retained in the six-item FRS6. The resultant FRS6 was internally consistent and related to various correlates in similar or better strengths as compared to the FRS16. The results of a separate sample in Study 2 indicated that the FRS6 demonstrated satisfactory internal reliability and correlated significantly with individual resilience, quality of life, anxiety, and depression in the expected directions. Both studies supported that the FRS6 is a psychometrically sound measure of family resilience and can be used in longitudinal studies that aim to chart the trajectory of family adjustment following life adversities.
Non-cardiac comorbidities in chronic heart failure

Non-cardiac comorbidity complicates heart failure care and is prevalent in one form or another for the majority of elderly patients with heart failure. This wide range of comorbidities, which includes respiratory comorbidities, renal dysfunction, anaemia, arthritis, cognitive dysfunction and depression, contributes to the progression of the disease and may alter the response to treatment. Polypharmacy is inevitable in these patients. Cardiologists and other physicians caring for patients with chronic heart failure (CHF) need to be vigilant to comorbid conditions that may complicate the care of these patients. Future trials should focus on optimal strategies for the comprehensive management of the elderly patients with CHF with multiple comorbidities rather than the isolated effects of single drugs in younger patients with few or no comorbidities.
Seasonal distribution of mycobacterial skin ulcers.

Chronic necrotizing skin ulcers caused by Mycobacterium ulcerans are a common and serious disorder in certain parts of the tropics. This infection was first described in Australia, but most of the reported cases have come from Uganda (where the disease is known as Buruli ulcer) and from the Congo. The disease is also known to occur
The effects of thiopentone and propofol on upper airway integrity

One hundred and fifty‐eight unpremedicated patients scheduled for elective surgery were allocated randomly to receive an unsupplemented induction dose of thiopentone or propofol. Visualisation of the vocal cords by standard laryngoscopy was possible more often after propofol (p < 0.01). Pharyngeal and laryngeal reactivity was similarity depressed more frequently.
Horizontal transfer of an adaptive chimeric photoreceptor from bryophytes to ferns

Significance Despite being one of the oldest groups of land plants, the majority of living ferns resulted from a relatively recent diversification following the rise of angiosperms. To exploit fully the new habitats created by angiosperm-dominated ecosystems, ferns had to evolve novel adaptive strategies to cope with the low-light conditions exerted by the angiosperm canopy. Neochrome, an unconventional photoreceptor that allows ferns to “see the light” better, was likely part of the solution. Surprisingly, we discovered that fern neochrome was derived from a bryophyte lineage via horizontal gene transfer (HGT). This finding not only provides the first evidence that a plant-to-plant HGT can have a profound evolutionary impact but also has implications for the evolution of photosensory systems in plants. Ferns are well known for their shade-dwelling habits. Their ability to thrive under low-light conditions has been linked to the evolution of a novel chimeric photoreceptor—neochrome—that fuses red-sensing phytochrome and blue-sensing phototropin modules into a single gene, thereby optimizing phototropic responses. Despite being implicated in facilitating the diversification of modern ferns, the origin of neochrome has remained a mystery. We present evidence for neochrome in hornworts (a bryophyte lineage) and demonstrate that ferns acquired neochrome from hornworts via horizontal gene transfer (HGT). Fern neochromes are nested within hornwort neochromes in our large-scale phylogenetic reconstructions of phototropin and phytochrome gene families. Divergence date estimates further support the HGT hypothesis, with fern and hornwort neochromes diverging 179 Mya, long after the split between the two plant lineages (at least 400 Mya). By analyzing the draft genome of the hornwort Anthoceros punctatus, we also discovered a previously unidentified phototropin gene that likely represents the ancestral lineage of the neochrome phototropin module. Thus, a neochrome originating in hornworts was transferred horizontally to ferns, where it may have played a significant role in the diversification of modern ferns.
of Th2 Cytokine-Producing Eosinophils IL-4 Induces Differentiation and Expansion

Innate effector cells that produce Th2-type cytokines are critical in Th2 cell-mediated immune responses. However, it is not known how these cells acquire the ability to produce Th2 cytokines. IL-4 is a potent inducer that directs differentiation of naive CD4 (cid:1) T cells into CD4 (cid:1) Th2 effector cells. To determine whether IL-4 can induce differentiation and expansion of Th2 cytokine-producing innate cells, we used mice whose il-4 gene was replaced by a knock-in green ﬂuorescence protein ( gfp ) gene. We found that, directly ex vivo, IL-4 increased the number of GFP (cid:1) cells in the airway and the lung tissue in an Ag-speciﬁc manner. The majority of GFP (cid:1) cells were eosinophils, suggesting that IL-4 plays a pivotal role in expanding IL-4-producing eosinophils in vivo. IL-4-producing eosinophils showed some unique features compared with IL-4-producing CD4 (cid:1) T cells. They exhibited biallelic expression of the il-4 gene when stimulated and were more dominant IL-4- and IL-5-producing cells. Furthermore, we show that IL-4 drove bone marrow progenitor cells to differentiate into Th2 cytokine-producing eosinophils in vitro. These results strongly suggest IL-4 is a potent factor in directing bone marrow progenitor cells to differentiate into Th2 cytokine-producing eosinophils. The Journal of Immunology, 2004, 172: 2059–2066.
La sostenibilidad: una nueva etapa en el periodismo ambiental y en el periodismo en general

La situacion de extralimitacion de la especie humana con respecto al resto de la naturaleza genera la necesidad de abogar por la sostenibilidad. Dentro del cambio global, el cambio climatico se esta erigiendo como el principal motor. Esta realidad afecta al Periodismo Ambiental y al periodismo en general, por ser reflejo de la realidad biofisica y por ejercer un papel importante, como actor, en la construccion de la representacion social tanto de la extralimitacion, como del cambio global, del cambio climatico o de la sostenibilidad.
Fitting Sentence Level Translation Evaluation with Many Dense Features

Sentence level evaluation in MT has turned out far more difficult than corpus level evaluation. Existing sentence level metrics employ a limited set of features, most of which are rather sparse at the sentence level, and their intricate models are rarely trained for ranking. This paper presents a simple linear model exploiting 33 relatively dense features, some of which are novel while others are known but seldom used, and train it under the learning-to-rank framework. We evaluate our metric on the standard WMT12 data showing that it outperforms the strong baseline METEOR. We also analyze the contribution of individual features and the choice of training data, language-pair vs. target-language data, providing new insights into this task.
Cardiovascular application of polyhedral oligomeric silsesquioxane nanomaterials: a glimpse into prospective horizons

Revolutionary advances in nanotechnology propose novel materials with superior properties for biomedical application. One of the most promising nanomaterials for biomedical application is polyhedral oligomeric silsesquioxane (POSS), an amazing nanocage consisting of an inner inorganic framework of silicon and oxygen atoms and an outer shell of organic groups. The unique properties of this nanoparticle has led to the development of a wide range of nanostructured copolymers with significantly enhanced properties including improved mechanical, chemical, and physical characteristics. Since POSS nanomaterials are highly biocompatible, biomedical application of POSS nanostructures has been intensely explored. One of the most promising areas of application of POSS nanomaterials is the development of cardiovascular implants. The incorporation of POSS into biocompatible polymers has resulted in advanced nanocomposite materials with improved hemocompatibility, antithrombogenicity, enhanced mechanical and surface properties, calcification resistance, and reduced inflammatory response, which make these materials the material of choice for cardiovascular implants. These highly versatile POSS derivatives have opened new horizons to the field of cardiovascular implant. Currently, application of POSS containing polymers in the development of new generation cardiovascular implants including heart valve prostheses, bypass grafts, and coronary stents is under intensive investigation, with encouraging outcomes.
Energy-Efficient WiFi Offloading and Network Management in Heterogeneous Wireless Networks

We consider the joint WiFi offloading, admission control, and network management for the integrated WiFi and OFDMA-based cellular network. Specifically, we propose a quality-of-service (QoS) and mobility-aware admission control scheme that efficiently offloads macrocell traffic to WiFi and integrates a novel bandwidth borrow-return strategy while guaranteeing QoS requirements for users. These QoS constraints are explicitly modeled considering the throughput performance of carrier sense multiple access with collision avoidance scheme in the IEEE 802.11 WLAN and the fractional frequency reuse in the downlink cellular network. Then, we develop an analytical model to derive the blocking probabilities for calls in different service areas of a cell. Based on this analysis, we study the joint base station switching, power control, and traffic offloading problem for energy minimization under QoS constraints. We consider the time-varying call traffic and develop an algorithm to find the optimal solution of the problem. Numerical results are presented to demonstrate the performance of the proposed cross-layer resource management framework in the integrated network.
The SPL-IT Query by Example Search on Speech system for MediaEval 2014

This document briefly describes the system submitted by the Speech Processing Lab of Instituto de Telecomunicacoes, pole of Coimbra (SPL-IT) to the Query by Example Search on Speech Task (QUESST) of MediaEval 2014. Our approach is based on merging results of a phoneme recognition system using three different languages. A version of Dynamic Time Warping (DTW) using posteriorgram distances was created to allow finding some of the peculiar search cases of this task. Our primary submission merges two approaches: simple DTW for detecting entire queries and a version where cutting final portions of queries is allowed. The late submission merges 5 approaches that account for all the search possibilities described for the task, though improved results were only observed in the evaluation dataset for type 3 queries.
Issues and future directions in traffic classification

Traffic classification technology has increased in relevance this decade, as it is now used in the definition and implementation of mechanisms for service differentiation, network design and engineering, security, accounting, advertising, and research. Over the past 10 years the research community and the networking industry have investigated, proposed and developed several classification approaches. While traffic classification techniques are improving in accuracy and efficiency, the continued proliferation of different Internet application behaviors, in addition to growing incentives to disguise some applications to avoid filtering or blocking, are among the reasons that traffic classification remains one of many open problems in Internet research. In this article we review recent achievements and discuss future directions in traffic classification, along with their trade-offs in applicability, reliability, and privacy. We outline the persistently unsolved challenges in the field over the last decade, and suggest several strategies for tackling these challenges to promote progress in the science of Internet traffic classification.
On optimal light configurations in photometric stereo

This paper develops new theory for the optimal placement of photometric stereo lighting in the presence of camera noise. We show that for three lights, any triplet of orthogonal light directions minimises the uncertainty in scaled normal computation. The assumptions are that the camera noise is additive and normally distributed, and uncertainty is defined as the expectation of squared distance of scale normal to the ground truth. If the camera noise is of zero mean and variance sigma2 the optimal (minimum) uncertainty in the scaled normal is 3sigma2 For case of n > 3 lights, we show that the minimum uncertainty is 9sigma2n, and identify sets of light configurations which reach this theoretical minimum
Point counts surveys of land birds at the Four Canyon Preserve, Ellis County, Oklahoma, 2014

Standardized point counts were used to quantify the relative abundance and diversity of birds in three distinct terrestrial habitats at the Four Canyon Preserve, a mixed-grass prairie natural area in northwestern Oklahoma. Surveys conducted in 2014 detected 38 species including most breeding birds expected to occur at the site. Relative abundance and frequency of occurrence were calculated for species observed, and total relative abundance and mean species richness were calculated for habitats and for the Preserve as a whole. Total abundance and mean species richness were highest for wooded canyon and lowest for upland grassland habitats. Results were compared with years 2005 and 2007 assessments to identify potential changes in the avifauna of the Preserve. Increases were noted for Cassin’s Sparrow (Aimophila cassinii), Western Meadowlark (Sturnella neglecta), and Northern Bobwhite (Colinus virginianus).
Self-Organization in Decentralized Networks: A Trial and Error Learning Approach

In this paper, the problem of channel selection and power control is jointly analyzed in the context of multiple-channel clustered ad-hoc networks, i.e., decentralized networks in which radio devices are arranged into groups (clusters) and each cluster is managed by a central controller (CC). This problem is modeled by game in normal form in which the corresponding utility functions are designed for making some of the Nash equilibria (NE) to coincide with the solutions to a global network optimization problem. In order to ensure that the network operates in the equilibria that are globally optimal, a learning algorithm based on the paradigm of trial and error learning is proposed. These results are presented in the most general form and therefore, they can also be seen as a framework for designing both games and learning algorithms with which decentralized networks can operate at global optimal points using only their available local knowledge. The pertinence of the game design and the learning algorithm are highlighted using specific scenarios in decentralized clustered ad hoc networks. Numerical results confirm the relevance of using appropriate utility functions and trial and error learning for enhancing the performance of decentralized networks.
Effects of Different Pyrethroids on Landing Behavior of Female Aedes aegypti, Anopheles quadrimaculatus, and Culex quinquefasciatus Mosquitoes (Diptera: Culicidae)

ABSTRACT Mosquitoes from three genera, Aedes aegypti L. , Anopheles quadrimaculatus Say, and Culex quinquefasciatus Say, were tested for facultative landing and resting behavior on pyrethroidtreated surfaces paired with adjacent untreated surfaces. The three pyrethroids tested were bifenthrin, deltamethrin, and lambda-cyhalothrin. Landing and resting behavior was video recorded and quantified using Observer XT software. Untreated control treatments were tested to show behavior in the absence of insecticides. In controls, the three species had different activity levels, with An. quadrimaculatus being the most active and Cx. quinquefasciatus being the least active. The three species had unique responses to different compounds tested. Landing frequency on adjacent untreated and treated filter papers did not differ for any compound or species at any time during the experiment. However, landing frequencies did differ between treatments and over time. Differences between treated and untreated sides were largely caused by changes in the length of time mosquitoes rested on each side. An. quadrimaculatus had a unique response to the presence of deltamethrin compared with the other species or compounds in which it spent an increased amount of time in contact with both treated and adjacent untreated surfaces. Cx. quinquefasciatus avoided all three compounds by the end of the experiment and rested longer on untreated sides. In most cases, modification of landing and resting behaviors occurred only after mosquitoes had the opportunity to come into contact and acquire a dose of pyrethroid. Bifenthrin had the fastest TK50 for all species. Other differences between compounds for each species are described. The term excito-repellency has produced confusion in the literature, and it is revisited and discussed with respect to the results, which justify the use of alternative terminology. The term “locomotive stimulant” is offered as an acceptable alternative.