Miracle-dz/UniFAR-FTUs huggingface dataset:
Corporate Intranet Implementation: Managing Emergent Technologies and Organizational Practices

This paper examines the adoption and development of intranets in large business organizations. The authors demonstrate that intranet technology introduces a host of new managerial and technical challenges and requires new approaches to IS development. Evidence from two European corporations indicates that the traditional division of labor and definition of work roles in IS development breaks down. The distinction between developers and users becomes increasingly blurred and new organizational roles and structures associated with intranets are emerging. However, ready-made organizational models for implementing and managing intranets do not exist and the two organizations in this study have followed two different approaches. One organization favors a “planned change” approach, emphasizing management control and careful planning. The other organization prefers an “improvisational” approach, emphasizing experimentation, innovation and local initiative.
Web page language identification based on URLs

Given only the URL of a web page, can we identify its language? This is the question that we examine in this paper. Such a language classifier is, for example, useful for crawlers of web search engines, which frequently try to satisfy certain language quotas. To determine the language of uncrawled web pages, they have to download the page, which might be wasteful, if the page is not in the desired language. With URL-based language classifiers these redundant downloads can be avoided. We apply a variety of machine learning algorithms to the language identification task and evaluate their performance in extensive experiments for five languages: English, French, German, Spanish and Italian. Our best methods achieve an F-measure, averaged over all languages, of around . 90 for both a random sample of 1,260 web page from a large web crawl and for 25k pages from the ODP directory. For 5k pages of web search engine results we even achieve an F-measure of . 96. The achieved recall for these collections is . 93, . 88 and . 95 respectively. Two independent human evaluators performed considerably worse on the task, with an F-measure of . 75 and a typical recall of a mere . 67. Using only country-code top-level domains, such as . de or . fr yields a good precision, but a typical recall of below . 60 and an F-measure of around . 68.
Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities

Degradation of the essential amino acid tryptophan along the kynurenine pathway (KP) yields several neuroactive intermediates, including the free radical generator 3-hydroxykynurenine, the excitotoxicN-methyl-d-aspartate (NMDA) receptor agonist quinolinic acid, and the NMDA and α7 nicotinic acetylcholine receptor antagonist kynurenic acid. The ambient levels of these compounds are determined by several KP enzymes, which in the brain are preferentially localized in astrocytes and microglial cells. Normal fluctuations in the brain levels of neuroactive KP intermediates might modulate several neurotransmitter systems. Impairment of KP metabolism is functionally significant and occurs in a variety of diseases that affect the brain. Pharmacological agents targeting specific KP enzymes are now available to manipulate the concentration of neuroactive KP intermediates in the brain. These compounds can be used to normalize KP defects, show remarkable efficacy in animal models of central nervous system disorders, and offer novel therapeutic opportunities.
Maternal attachment and mind-mindedness: the role of emotional specificity

We explored the relation between maternal mind-mindedness (i.e., a mother’s tendency to verbally refer to her infant’s mental world through use of infant-directed mental state terms) and maternal attachment. Mothers (N = 76), classified prenatally as Autonomous, Dismissing, Preoccupied, and Unresolved using the Adult Attachment Interview (AAI), simulated speaking to their 6-month-old infants in positive and negative emotion contexts. Mothers’ utterances were coded for frequency of use of emotion and cognition-related mind-minded terms. Results indicated a significant negative relation between coherence of mind scores on the AAI and emotion mind-mindedness in the positive emotion context. When differences between insecure attachment categories and mind-mindedness were explored, results indicated that mothers with Preoccupied attachments were significantly more likely to use emotion-related terms than mothers with Dismissing attachments and that these differences were most pronounced in the negative emotion context. A similar pattern was found for mothers with Unresolved attachments compared to those with organized (Autonomous, Dismissing, Preoccupied) attachment classifications, however use of emotion mind-minded terms did not differ by emotional context. Future research directions highlighting the importance of exploring the unique contribution of Preoccupied, Dismissing and Unresolved attachment and emotional context in the exploration of mind-mindedness are discussed.
The inverse source problem of electromagnetics: linear operator formalism and minimum energy solution

We address an inverse source problem consisting of finding the time-harmonic current distribution (source) with minimum L/sup 2/ norm (minimum energy) that generates a prescribed electromagnetic field provided outside the source's support. Using the well-known multipole expansion of the electromagnetic field we compute, via a linear operator formalism, the sought-after minimum L/sup 2/ norm current distribution consistent with the data.
Secure Communication With a Wireless-Powered Friendly Jammer

In this paper, we propose using a wireless-powered friendly jammer to enable secure communication between a source node and destination node, in the presence of an eavesdropper. We consider a two-phase communication protocol with fixed-rate transmission. In the first phase, wireless power transfer is conducted from the source to the jammer. In the second phase, the source transmits the information-bearing signal under the protection of a jamming signal sent by the jammer using the harvested energy in the first phase. We analytically characterize the long-term behavior of the proposed protocol and derive a closed-form expression for the throughput. We further optimize the rate parameters for maximizing the throughput subject to a secrecy outage probability constraint. Our analytical results show that the throughput performance differs significantly between the single-antenna jammer case and the multiantenna jammer case. For instance, as the source transmit power increases, the throughput quickly reaches an upper bound with single-antenna jammer, while the throughput grows unbounded with multiantenna jammer. Our numerical results also validate the derived analytical results.
Technology and Learning Base for Sustainable Energy Conservation

The aim of energy conservation design is to provide two types of sustainability in terms of important energy topics: eco-friendly technology and eco-friendly humanity through building awareness from childhood. Most research concerns technology design such as electrical appliances for energy saving, but the research that will be discussed is to build awareness for technology users by creating awareness in children from the age of 7-12 years old, covering elementary school grades 1-6. This is suitable for elementary school students according to Skinner’s theory of learning.
Hybridization and speciation

Hybridization has many and varied impacts on the process of speciation. Hybridization may slow or reverse differentiation by allowing gene flow and recombination. It may accelerate speciation via adaptive introgression or cause near‐instantaneous speciation by allopolyploidization. It may have multiple effects at different stages and in different spatial contexts within a single speciation event. We offer a perspective on the context and evolutionary significance of hybridization during speciation, highlighting issues of current interest and debate. In secondary contact zones, it is uncertain if barriers to gene flow will be strengthened or broken down due to recombination and gene flow. Theory and empirical evidence suggest the latter is more likely, except within and around strongly selected genomic regions. Hybridization may contribute to speciation through the formation of new hybrid taxa, whereas introgression of a few loci may promote adaptive divergence and so facilitate speciation. Gene regulatory networks, epigenetic effects and the evolution of selfish genetic material in the genome suggest that the Dobzhansky–Muller model of hybrid incompatibilities requires a broader interpretation. Finally, although the incidence of reinforcement remains uncertain, this and other interactions in areas of sympatry may have knock‐on effects on speciation both within and outside regions of hybridization.
A Gene-Phenotype Network for the Laboratory Mouse and Its Implications for Systematic Phenotyping

The laboratory mouse is the pre-eminent model organism for the dissection of human disease pathways. With the advent of a comprehensive panel of gene knockouts, projects to characterise the phenotypes of all knockout lines are being initiated. The range of genotype-phenotype associations can be represented using the Mammalian Phenotype ontology. Using publicly available data annotated with this ontology we have constructed gene and phenotype networks representing these associations. These networks show a scale-free, hierarchical and modular character and community structure. They also exhibit enrichment for gene coexpression, protein-protein interactions and Gene Ontology annotation similarity. Close association between gene communities and some high-level ontology terms suggests that systematic phenotyping can provide a direct insight into underlying pathways. However some phenotypes are distributed more diffusely across gene networks, likely reflecting the pleiotropic roles of many genes. Phenotype communities show a many-to-many relationship to human disease communities, but stronger overlap at more granular levels of description. This may suggest that systematic phenotyping projects should aim for high granularity annotations to maximise their relevance to human disease.
Second Home Owners As Tourism Trend-Setters: A Case Of Residential Tourists In Gran Canaria

This study examines German-speaking second home owners on Gran Canaria, Spain as an example of one of the growing groups of non-conventional tourists. International second home ownership has been increasing rapidly over the last decades with Spain and particularly the Canary Islands being a hot spot for residential tourism. Despite the maturity of the destination, there are few studies on second home tourists on the Canary Islands. Moreover, while second home tourism, including its international forms, has been present as a distinct type of tourism, academic attention has not sufficiently compared and counterposed mass and residential tourism. The aim of this paper is to investigate distinctions between second home and mass tourists to define the features of non conventional travellers in light of the contemporary growth of alternative ways to engage in recreation. This paper argues that second home tourism reflects the emerging tourism trends of “home stay tourism” and “living like a local” that will reshape the nature of mass tourism as well as receiving destinations. In order to understand the features of rapidly growing alternative or non-mass tourists, this paper examines the experiences of German-speaking second home owners on Gran Canaria. The results reveal a number of distinctive features that collectively help to understand contemporary non conventional tourists.
Telbivudine treatment of hepatitis B virus-infected pregnant women at different gestational stages for the prevention of mother-to-child transmission

AbstractThis prospective study evaluated the viability of telbivudine for blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV) infection.Pregnant women positive for the hepatitis B surface antigen began telbivudine treatment before 14 weeks of gestation (i.e., early), between 14 and 28 weeks of gestation (late), or not at all (control). In the late-treatment group, 55 women terminated telbivudine therapy within puerperium. All neonates underwent routine hepatitis B immunoglobulin plus vaccination. Mothers and infants were followed for 7 months after birth.Pregnancy outcomes were similar among the 3 groups. HBV MTCT rates in the early and late treatment and control groups were 0, 0, and 4.69%, respectively. The rates of infant vaccination success among the 3 groups were similar, as were neonatal outcomes including birth weights, asphyxia, hyperbilirubinemia, Apgar score, birth defects, and weight and height at 7 months. Puerperal discontinuation of telbivudine did not increase the alanine transaminase value at 7 months after birth, but increased serum HBV DNA levels, and rates of positive hepatitis Be-antigen.Telbivudine treatment in HBV-infected pregnant women was associated with lower serum HBV DNA levels and reduced rates of HBV MTCT; there were no associated changes in pregnancy or neonatal outcomes at birth or 7 months after birth, or in the rate of infant vaccination success. Puerperal drug withdrawal after short-term antiviral therapy will not influence hepatic function, but may increase virus replication.
In roots of Arabidopsis thaliana, the damage-associated molecular pattern AtPep1 is a stronger elicitor of immune signalling than flg22 or the chitin heptamer

Plants interpret their immediate environment through perception of small molecules. Microbe-associated molecular patterns (MAMPs) such as flagellin and chitin are likely to be more abundant in the rhizosphere than plant-derived damage-associated molecular patterns (DAMPs). We investigated how the Arabidopsis thaliana root interprets MAMPs and DAMPs as danger signals. We monitored root development during exposure to increasing concentrations of the MAMPs flg22 and the chitin heptamer as well as of the DAMP AtPep1. The tissue-specific expression of defence-related genes in roots was analysed using a toolkit of promoter::YFPN lines reporting jasmonic acid (JA)-, salicylic acid (SA)-, ethylene (ET)- and reactive oxygen species (ROS)- dependent signalling. Finally, marker responses were analysed during invasion by the root pathogen Fusarium oxysporum. The DAMP AtPep1 triggered a stronger activation of the defence markers compared to flg22 and the chitin heptamer. In contrast to the tested MAMPs, AtPep1 induced SA- and JA-signalling markers in the root and caused a severe inhibition of root growth. Fungal attack resulted in a strong activation of defence genes in tissues close to the invading fungal hyphae. The results collectively suggest that AtPep1 presents a stronger danger signal to the Arabidopsis root than the MAMPs flg22 and chitin heptamer.
Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma

Hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, c-Met, have been implicated in the growth and progression of a variety of solid human tumors. Thus, inhibiting HGF/SF:c-Met signaling may provide a novel therapeutic approach for treating human tumors. We have generated and characterized fully human monoclonal antibodies that bind to and neutralize human HGF/SF. In this study, we tested the effects of the investigational, human anti-human HGF/SF monoclonal antibody, AMG 102, and a mixture of mouse anti-human HGF/SF monoclonal antibodies (Amix) on HGF/SF-mediated cell migration, proliferation, and invasion in vitro. Both agents had high HGF/SF-neutralizing activity in these cell-based assays. The HGF/SF:c-Met pathway has been implicated in the growth of sarcomas; thus, we also investigated the effect of AMG 102 on the growth of human leiomyosarcoma (SK-LMS-1) in HGF/SF transgenic C3H severe combined immunodeficient mice engineered to express high levels of human HGF/SF, as well as tumor growth of an autocrine variant of the SK-LMS-1 cell line (SK-LMS-1TO) in nude mice. The results indicate that interrupting autocrine and/or paracrine HGF/SF:c-Met signaling with AMG 102 has profound antitumor effects. These findings suggest that blocking HGF/SF:c-Met signaling may provide a potent intervention strategy to treat patients with HGF/SF:c-Met–dependent tumors. [Mol Cancer Ther 2009;8(10):2803–10]
Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl)guanine (BRL 39123) in cell culture

The activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) against several herpesviruses was compared with that of acyclovir (ACV). In plaque reduction tests with clinical isolates of herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella-zoster virus, mean 50% inhibitory concentrations (IC50S) (n = number tested) for BRL 39123 were 0.4 (n = 17), 1.5 (n = 13), and 3.1 (n = 5) micrograms/ml, respectively. Corresponding IC50S for ACV were 0.2, 0.6, and 3.8 micrograms/ml. Cytomegalovirus was relatively resistant to BRL 39123 (IC50, 51 micrograms/ml), but equid herpesvirus 1, bovid herpesvirus 2, and felid herpesvirus 1 were susceptible (IC50S, 1.6, 1.2, and 0.9 micrograms/ml, respectively). BRL 39123 was inactive against an HSV-1 strain which does not express thymidine kinase activity, but a DNA polymerase mutant selected for resistance to ACV was sensitive to BRL 39123 (IC50, 1.5 micrograms/ml). In contrast to the results from plaque reduction tests, BRL 39123 was more active than ACV against HSV-1 and of equal activity against HSV-2 in virus yield reduction assays in MRC-5 cells. After treatment of HSV-infected cultures for short periods, BRL 39123 was considerably more effective than ACV at reducing virus replication, and furthermore, after removal of extracellular BRL 39123, virus replication remained depressed for long periods, whereas such persistent activity was not observed with ACV. Neither compound significantly affected MRC-5 cell replication at 100 micrograms/ml, but at 300 micrograms/ml BRL 39123 was more inhibitory than ACV.
Vegetation species mapping in a coastal-dune ecosystem using high resolution satellite imagery

Vegetation mapping is a priority when managing natural protected areas. In this context, very high resolution satellite remote sensing data can be fundamental in providing accurate vegetation cartography at species level. In this work, a complete processing methodology has been developed and validated in a complex vulnerable coastal-dune ecosystem. Specifically, the analysis has been carried out using WorldView-2 imagery, which offers spatial and spectral resolutions. A thorough assessment of 5 atmospheric correction models has been performed using real reflectance measures from a field radiometry campaign. To select the classification methodology, different strategies have been evaluated, including additional spectral (23 vegetation indices) and spatial (4 texture parameters) information to the multispectral bands. Likewise, the application of linear unmixing techniques has been tested and abundance maps of each plant species have been generated using the library of spectral signatures recorded during the campaign. After the analysis conducted, a new methodology has been proposed based on the use of the 6S atmospheric model and the Support Vector Machine classification algorithm applied to a combination of different spectral and spatial input data. Specifically, an overall accuracy of 88,03% was achieved combining the corrected multispectral bands plus a vegetation index (MSAVI2) and texture information (variance of the first principal component). Furthermore, the methodology has been validated by photointerpretation and 3 plant species achieve significant accuracy: Tamarix canariensis (94,9%), Juncus acutus (85,7%) and Launaea arborescens (62,4%). Finally, the classified procedure comparing maps for different seasons has also shown robustness to changes in the phenological state of the vegetation.
On using multiple quality link metrics with Destination Sequenced Distance Vector protocol for Wireless Multi-hop Networks

In this paper, we compare and analyze performance of five quality link metrics for Wireless Multi-hop Networks (WMhNs). The metrics are based on loss probability measurements; ETX, ETT, InvETX, ML and MD, in a distance vector routing protocol; DSDV. Among these selected metrics, we have implemented ML, MD, InvETX and ETT in DSDV which are previously implemented with different protocols; ML, MD, InvETX are implemented with OLSR, while ETT is implemented in MR-LQSR. For our comparison, we have selected Throughput, Normalized Routing Load (NRL) and End-to-End Delay (E2ED) as performance parameters. Finally, we deduce that InvETX due to low computational burden and link asymmetry measurement outperforms among all metrics.
Caching in wireless networks

We consider the problem of delivering content cached in a wireless network of n nodes randomly located on a square of area n. In the most general form, this can be analyzed by considering the 2n × n-dimensional caching capacity region of the wireless network. We propose a communication scheme for transmission of messages cached in the network. This provides an inner bound to the caching capacity region.
Sand fly captures with Disney traps in area of occurrence of Leishmania (Leishmania) amazonensis in the state of Mato Grosso do Sul, mid-western Brazil.

INTRODUCTION The work was conducted to study phlebotomine fauna (Diptera: Psychodidae) and aspects of American cutaneous leishmaniasis transmission in a forested area where Leishmania (Leishmania) amazonensis occurs, situated in the municipality of Bela Vista, State of Mato Grosso do Sul, Brazil. METHODS The captures were conducted with modified Disney traps, using hamster (Mesocricetus auratus) as bait, from May 2004 to January 2006. RESULTS Ten species of phlebotomine sandflies were captured: Brumptomyia avellari, Brumptomyia brumpti, Bichromomyia flaviscutellata, Evandromyia bourrouli, Evandromyia lenti, Lutzomyia longipalpis, Psathyromyia campograndensis, Psathyromyia punctigeniculata, Psathyromyia shannoni and Sciopemyia sordellii. The two predominant species were Ev bourrouli (57.3%) and Bi flaviscutellata (41.4%), present at all sampling sites. Two of the 36 hamsters used as bait presented natural infection with Leishmania. The parasite was identified as Leishmania (Leishmania) amazonensis. CONCLUSIONS Analysis of the results revealed the efficiency of Disney traps for capturing Bichromomyia flaviscutellata and the simultaneous presence of both vector and the Leishmania species transmitted by the same can be considered a predictive factor of the occurrence of leishmaniasis outbreaks for the human population that occupies the location.
Reducing mental illness stigma and discrimination — everybody's business

The stigma associated with schizophrenia is pervasive, both in the community and among healthcare workers, and forms a real barrier to optimal recovery from the illness. The negative consequences of stigma include discrimination in housing, education and employment, and increased feelings of hopelessness in people with schizophrenia. Health professionals have a responsibility to improve their own attitudes and behaviour towards people with schizophrenia so they do not contribute to the stigma. Educational campaigns aimed at people in the community and media personnel could help to demystify mental illness and reduce the portrayal of offensive stereotypes of people with schizophrenia.