Miracle-dz/UniFAR-FTUs huggingface dataset:
Why do community-based athletes choose to participate in a modified, low-risk form of boxing? An interpretative phenomenological analysis

Over the past eight years a modified, low-risk form of boxing known as Box'Tag has emerged in Australia. It has been designed to emphasise high levels of fitness, skill and personal enjoyment, while excluding those aspects of traditional boxing that have raised medical, ethical and legal concerns. Strikes to the head are prohibited, as are any impacts above a moderate level of force. Although uptake to date has been encouraging, a question remains as to whether Box'Tag can be developed in a way that will lead to sustainable large-scale community participation. Presently, there are only a few exemplar clubs where Box'Tag programs are being conducted. The purpose of the current study was to investigate, analyze and interpret one of these programs to discover the factors that have influenced a number of community-based athletes to have a two-year involvement with a modified, low- risk form of boxing. This was accomplished by allowing the participants to recall their experiences free of any judgment and by making sense of their perceptions through an interpretative phenomenological analysis. Sustained participation in Box'Tag appears to have resulted from a sense of belonging to a special community, strong coach-athlete relationships, perception that the training is purposeful and a focus on safety.
The role of the gubernaculum in the descent and undescent of the testis

Testicular descent to the scrotum involves complex anatomical rearrangements and hormonal regulation. The gubernaculum remains the key structure, undergoing the `swelling reaction' in the transabdominal phase, and actively migrating out of the abdominal wall to the scrotum in the inguinoscrotal phase. Insulin-like hormone 3 (Insl3) is the primary regulator of the first phase, possibly augmented by Müllerian inhibiting substance/anitmüllerian hormone (MIS/AMH), and regression of the cranial suspensory ligament by testosterone. The inguinoscrotal phase is controlled by androgens acting both directly on the gubernaculum and indirectly via the genitofemoral nerve, and release of calcitonin gene-related peptide from its sensory fibres. Outgrowth of the gubernaculum and elongation to the scrotum has many similarities to an embryonic limb bud. Cryptorchidism occurs because of both failure of migration congenitally, and failure of elongation of the spermatic cord postnatally. Germ cell development postnatally is disturbed in congenital cryptorchidism, but our current understanding of germ cell biology suggests that early orchidopexy, around 6 months of age, should provide a significant improvement in prognosis compared with a previous generation. Hormone treatment is not currently recommended. Acquired cryptorchid testes may need orchidopexy once they no longer reach the scrotum, although this remains controversial.
Cardiovascular effects of bupropion in depressed patients with heart disease.

OBJECTIVE The cardiovascular effects of therapeutic plasma levels of tricyclic antidepressants in depressed patients with and without preexisting cardiac disease have been well characterized and include orthostatic hypotension and conduction delay. Bupropion, structurally unrelated to tricyclic antidepressants, is relatively free of cardiac side effects in depressed patients without cardiac disease. However, it is unknown whether bupropion is safe for depressed patients with preexisting heart disease, so the authors studied the cardiovascular effects of bupropion in such patients. METHOD The subjects were 36 inpatients with DSM-III major depression and preexisting left ventricular impairment (N = 15), ventricular arrhythmias (N = 15), and/or conduction disease (N = 21). The patients continued their cardiac drug regimens and received bupropion for 3 weeks (mean +/- SD dose = 442 +/- 47 mg/day). Cardiovascular functioning was measured by pulse, blood pressure, high-speed ECG, 24-hour portable ECG, and radionuclide angiography. RESULTS Although bupropion caused a rise in supine blood pressure, it did not cause significant conduction complications, did not exacerbate ventricular arrhythmias, had a low rate of orthostatic hypotension, and had no effect on pulse rate. However, bupropion treatment was discontinued for 14% of the patients because of adverse effects, including exacerbation of baseline hypertension in two patients. CONCLUSIONS The cardiovascular profile of bupropion may make this drug a useful agent in the treatment of the depressed patient with preexisting cardiovascular disease. Further studies, with longer durations of bupropion treatment and more subjects, are needed to confirm these findings.
Conflict Resolution Education in Indonesia: Mapping adaptations and meanings

NOEL, BRETT RILEY, Ph.D., August 2008, Curriculum and Instruction Conflict Resolution Education in Indonesia: Mapping Adaptation and Meanings (301 pp.) Director of Dissertation: Dianne M. Gut This study examined the ways professors in teacher education departments in two universities in East Java translated and adapted Conflict Resolution Education (CRE) methods. To map the ways they adapted and understood cooperative learning (CL) and non-coercive classroom management (NCCM), a critical ethnography (a blend of ethnography and action research) was done based on Carspecken‘s (1996) design. It was conducted from October 2004 to February 2008 in two universities in East Java. The results were based upon field work that included passive and participatory observations, semi-structured interviews, document analysis, surveys, and critical dialogues with primary informants. Analysis was framed using Roger‘s (1995) diffusion stages. Findings indicated that although there were some very serious challenges to the adoption of these two innovations, there were points where bridges could be built in both practice and understanding. Barriers included informants‘ struggles to shift from teacher-centered to student-centered instruction while still maintaining culturally prescribed expressions of authority. Related themes were challenges instructors encountered in engaging students through facilitation practices and reciprocal communication. Approved: _____________________________________________________________ Dianne M. Gut Associate Professor of Teacher Education
In Vitro Motility Analysis of Actin-Tropomyosin Regulation by Troponin and Calcium

In striated muscles, contractility is controlled by Ca binding to the regulatory protein complex troponin, which is a component of the thin filaments. Troponin is an allosteric inhibitor acting on tropomyosin to switch the thin filament between “on” and “off” states. We have used an in vitro motility assay to examine troponin regulation of individual actin-tropomyosin filaments moving over immobilized skeletal muscle heavy meromyosin. The most striking observation is that the actin-tropomyosin filament appears to be regulated as a single unit. At pCa 9.0, addition of up to 4 nM troponin causes the proportion of filaments motile to decrease from >85% to 20% with no dissociation of the filaments from the heavy meromyosin surface or change in velocity. Increasing Ca concentration causes the filaments to be switched back on with half-maximal increase in the proportion of filaments motile at pCa 5.8-6.0 and a modest increase in filament velocity. This is an “all or none” process in which an entire filament, up to 15 μm long, switches rapidly as a single cooperative unit. Thus, the effect of Ca upon the thin filament is to recruit motile filaments.
Diabetes, Gestational Diabetes and the Risk of Cancer in Women: Epidemiologic Evidence and Possible Biologic Mechanisms

At present, more than 10% of adult American women are diagnosed with diabetes mellitus (DM). As the prevalence of the disease increases, there is greater interest in the relationship between DM and other major health issues, such as cancer – one of the leading causes of death in the western world. This paper reviews the literature on the relationship between Type 2 DM and different types of cancer among women. We discuss the possible biological mechanisms that may link diabetes and cancer, important confounders, shared risk factors and a short review of the epidemiologic literature on the association between Type 2 DM and cancer of specific organs (pancreas, liver, colorectal, bladder, endometrial, non-Hodgkin's lymphoma and breast). We also examine the association between gestational diabetes, a closely related risk factor for DM in women, and subsequent risk of cancer. Cancer survival of diabetic women is also briefly discussed. The paper concludes with an agenda for future research targeting the relationship between diabetes and cancer.
Self-Control, Thrill Seeking, and Crime

Self-control theory (SCT), as a control theory, assumes that the pleasures gained from crime are equally obvious and attractive to all. This study brings a consideration of crime as a process into SCT, recognizing that the sensations inherent in offending may not be equally attractive to everyone. In doing so, we test the theory’s equal motivation assumption, bringing a consideration of individual differences in thrill seeking to the fore. Drawing on theory and research on the personality characteristic thrill seeking, we hypothesize that thrill seeking and self-control have independent influences on offending: that motivation to the process of crime matters. In addition, we investigate whether the effects of self-control are contingent on levels of thrill seeking, in part because high thrill seekers are less averse to the process of risk. These hypotheses are tested using data from the Family and Community Health Study, a sample of roughly 700 African American youth and their families. A new measure of self-control is employed in tandem with an existing attitudinal measure of self-control and thrill seeking. Consistent with hypotheses, the results suggest that self-control and thrill seeking have largely independent influences on offending and that the effects of self-control are contingent on levels of thrill seeking. These results provide further evidence that SCT’s assumption of equal motivation to crime is untenable, as individual differences in the personality characteristic thrill seeking influence the likelihood of offending.
Linear inverse source estimate of combined EEG and MEG data related to voluntary movements

A method for the modeling of human movement‐related cortical activity from combined electroencephalography (EEG) and magnetoencephalography (MEG) data is proposed. This method includes a subject's multi‐compartment head model (scalp, skull, dura mater, cortex) constructed from magnetic resonance images, multi‐dipole source model, and a regularized linear inverse source estimate based on boundary element mathematics. Linear inverse source estimates of cortical activity were regularized by taking into account the covariance of background EG and MEG sensor noise. EEG (121 sensors) and MEG (43 sensors) data were recorded in separate sessions whereas normal subjects executed voluntary right one‐digit movements. Linear inverse source solution of EEG, MEG, and EEG‐MEG data were quantitatively evaluated by using three performance indexes. The first two indexes (Dipole Localization Error [DLE] and Spatial Dispersion [SDis]) were used to compute the localization power for the source solutions obtained. Such indexes were based on the information provided by the column of the resolution matrix (i.e., impulse response). Ideal DLE values tend to zero (the source current was correctly retrieved by the procedure). In contrast, high DLE values suggest severe mislocalization in the source reconstruction. A high value of SDis at a source space point mean that such a source will be retrieved by a large area with the linear inverse source estimation. The remaining performance index assessed the quality of the source solution based on the information provided by the rows of the resolution matrix R, i.e., resolution kernels. The i‐th resolution kernels of the matrix R describe how the estimation of the i‐th source is distorted by the concomitant activity of all other sources. A statistically significant lower dipole localization error was observed and lower spatial dispersion in source solutions produced by combined EEG‐MEG data than from EEG and MEG data considered separately (P < 0.05). These effects were not due to an increased number of sensors in the combined EEG‐MEG solutions. They result from the independence of source information conveyed by the multimodal measurements. From a physiological point of view, the linear inverse source solution of EEG‐MEG data suggested a contralaterally preponderant bilateral activation of primary sensorimotor cortex from the preparation to the execution of the movement. This activation was associated with that of the supplementary motor area. The activation of bilateral primary sensorimotor cortical areas was greater during the processing of afferent information related to the ongoing movement than in the preparation for the motor act. In conclusion, the linear inverse source estimate of combined MEG and EEG data improves the estimate of movement‐related cortical activity. Hum. Brain Mapping 14:197–209, 2001. © 2001 Wiley‐Liss, Inc.
Automated crystal orientation and phase mapping of iron-oxide nanocrystals in a transmission electron microscope

The development of novel materials for micro- and nano-electronics requires reliable characterizations of structures, sizes, and orientations of thin polycrystalline films and ensembles of nanocrystals. The electron backscatter diffraction (EBSD) technique (also known as orientation imaging microscopy or back-scatter Kikuchi diffraction method) in a scanning electron microscope (SEM) is often employed for structural characterization of this kind of materials. EBSD in SEM is, however, sensitive to the plastic deformation state of the crystals as well as to structural damage or contamination of the crystal surfaces.
Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children.

CONTEXT Free fatty acids (FFAs) and triglycerides (TGs) are altered postburn, but whether these alterations are associated with postburn outcomes is not clear. OBJECTIVE The aim of the present study was to analyze lipid metabolic profiles in pediatric burn patients and to correlate these profiles with patient outcomes and hospital courses. DESIGN AND SETTING We conducted a prospective cohort study at an academic pediatric hospital burn center. PATIENTS Our study included 219 pediatric burn patients. MAIN OUTCOME MEASURES Patients were stratified according to their plasma TG and FFA levels. Main patient outcomes, such as postburn morbidity and mortality, and clinical metabolic markers were analyzed. RESULTS All groups were similar in demographics and injury characteristics. Patients with elevated TGs had significantly worse clinical outcomes associated with increased acute-phase protein synthesis indicating augmented inflammation and hypermetabolism, whereas increased FFAs did not seem to profoundly alter postburn outcomes. CONCLUSIONS Elevated TGs, but not FFAs, postburn are associated with worsened organ function and clinical outcomes.
Naltrexone: report of lack of hepatotoxicity in acute viral hepatitis, with a review of the literature

Many clinicians appear to be concerned about the potential hepatotoxicity of the opiate antagonist naltrexone (NTX) and this may be one reason why it is not used more widely in treating both heroin and alcohol abusers. Some much‐quoted early studies noted abnormalities in liver function tests (LFTs) in very obese patients taking high doses, although there was no evidence of clinically significant liver dysfunction. These concerns may be reinforced by advice in the UK product information sheet to perform LFTs before and during treatment, by high infection rates with hepatitis C virus (HCV) among injecting heroin addicts and by the frequency of abnormal LFTs in alcohol abusers. We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant. A decision was made not to remove the implant but the hepatitis resolved completely and uneventfully well within the normal time‐scale. A review of the literature indicates that even when given at much higher doses than are needed for treating heroin or alcohol abusers, there is no evidence that NTX causes clinically significant liver disease or exacerbates, even at high doses, serious pre‐existing liver disease. During the past decade, NTX has been shown to be safe and effective in the treatment of pruritus associated with severe jaundice caused by severe and sometimes life‐threatening cirrhosis and other liver diseases. Its safety, even in these extreme conditions, is particularly reassuring. We suggest that it may be more appropriate and economical to advise patients to report promptly any suspected side effects than to perform regular LFTs, which may be misleading.
Uncovering Hypercoagulability in Sepsis Using ROTEM® Thromboelastometry: A Case Series

This case series presents three patients with sepsis/septic shock in whom standard coagulation tests (interna- tional normalized ratio, activated partial thromboplastin time, fibrinogen, antithrombin, thrombocytes) and ROTEM ® thromboelastometry (InTEM, ExTEM, FibTEM) were simultaneously performed. Although all patients showed signifi- cantly prolonged plasmatic coagulation times with a putatively increased risk of bleeding, ROTEM ® thromboelastometry revealed normal clotting times and even signs of hypercoagulability. Therefore, no coagulation active therapy was per- formed in any patient, not even before invasive procedures or major surgical interventions. No bleeding occurred in any study patient during surgery or the subsequent stay on the intensive care unit. These observations suggest that some criti- cally ill patients with sepsis and abnormal standard coagulation tests may in fact have hypercoagulability. ROTEM ® thromboelastometry can add important information in these patients and enable that blood products are used targeted and only for substitution of relevant deficencies. Future studies are necessary to validate these preliminary findings.
A three port high gain non-isolated DC-DC converter for photovoltaic applications

In photovoltaic (PV) applications, power electronic converters play a vital role in transferring power from source to load. In general, operating voltages of PV arrays are low. To interface them with high voltage DC bus, a high voltage conversion system is needed which is provided by high gain topologies. Moreover, to increase the power density, efficiency of conversion and decrease cost, recent developments involve use of multiport converters which are in general multi-input converters capable of interfacing different renewable sources to a single structure. However many topologies reported in the literature achieve only nominal voltage gain between source and output. In this paper, a new topology is proposed by combining the advantages of both high gain and multi-input converters. The proposed topology has two input ports (i) A bidirectional port for energy storage device (ii) A unidirectional port for PV source. Coupled inductor technique is used to obtain high voltage gain. The topology along with theoretical analysis is presented to explain the principle of operation. This analysis is then compared with simulation results from MATLAB-Simulink to validate operating principle of the proposed topology.
Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues.

BACKGROUND The impact of cognitive impairment on activities of daily living (ADL) is being used as a major criterion for differentiating between mild cognitive impairment (MCI) and dementia. The concept of an ADL threshold that separates MCI from dementia, however, appears to be improbable for several reasons. OBJECTIVES To determine whether complex ADL are impaired in patients with MCI; to examine the usefulness of the assessment of ADL impairment for the diagnosis of MCI; to explore whether both cognitive testing and assessment of impaired ADL are significant predictors of the diagnosis according to the diagnostic gold standard of MCI. DESIGN Cross-sectional study. SETTING University-based outpatient clinic. SUBJECTS A total of 45 elderly MCI patients diagnosed according to research diagnostic criteria and 30 age-matched cognitively unimpaired controls. METHODS Clinical assessment - Alzheimer's disease Assessment scale, cognitive subscale (ADAS-cog) for the assessment of cognitive functions, Alzheimer's disease Cooperative Study scale for ADL in MCI (ADCS-MCI-ADL) for the assessment of impairments of complex ADL. Statistical evaluation - Mann-Whitney U tests for significant differences on measures of cognition and everyday functioning. Non-parametric correlations for associations between ADL and cognitive ability. Receiver operator curve (ROC) analyses to identify optimal cut-off scores on the ADCS-MCI-ADL and ADAS-cog scales to differentiate between MCI patients and controls. Binary logistic regression analyses to predict the diagnosis of MCI on the basis of the above-mentioned instruments. RESULTS Patients scored significantly higher than controls on the ADAS-cog scale and significantly lower on the ADCS-MCI-ADL scale. There was a significant negative correlation of the above-mentioned scales in MCI patients (r = -0.46, P < 0.01). Both instruments discriminated well between patients and controls (ADCS-MCI-ADL: optimal cut-off 52 points, sensitivity 0.89, specificity 0.97; ADAS-cog: optimal cut-off 10 points, sensitivity 0.78, specificity 1.0). With regard to the linear predictor in the logistic regression built, both instruments were strong predictors of the diagnosis according to the diagnostic gold standard (ADCS-MCI-ADL: P = 0.002; ADAS-cog: P = 0.041). CONCLUSION Impairment of ADL is already present in MCI. Therefore, intact ADL cannot be used as a criterion to define the syndrome of MCI and to distinguish it from mild dementia. The assessment of complex ADL is probably useful for the diagnosis of MCI.
Cardiac autonomic control mechanisms in power-frequency magnetic fields: a multistudy analysis.

Heart rate variability (HRV), a noninvasive indicator of autonomic control of cardiac activity, is predictive of long-term cardiac morbidity and mortality. Epidemiologic research suggests that occupational exposure to power-frequency magnetic fields may be associated with autonomically mediated cardiac mortality. Results from our laboratory studies of humans exposed to 60-Hz magnetic fields overnight, however, are inconsistent. HRV is altered in some studies but not others. To clarify this, the pooled data from seven studies involving 172 men were analyzed to test specific hypotheses concerning this inconsistency. After analysis, we excluded a) measurement drift or instability over time because HRV was stable under sham-exposed conditions across all studies; b) inadequate statistical power or failure to maintain double-blind controls; c) differences in field intensity (28.3 vs. 127.3 microT) or exposure pattern (intermittent versus continuous) as main effects; or d) the inclusion of individuals sensitive to magnetic field exposure in some studies but not others. Four separate analytic techniques failed to identify a valid subpopulation of sensitive individuals. In some studies, however, hourly blood samples were collected using an indwelling venous catheter. HRV alterations occurred during intermittent exposure in these studies (p < 0.05) but not in similar studies without blood sampling. This result suggests a field interaction with modest arousal or disturbance. Because HRV is tightly coupled to electroencephalographic activity during sleep, these results are physiologically plausible and suggest that HRV alterations during exposure to magnetic fields may occur when accompanied by increases in physiologic arousal, stress, or sleep disturbance. ImagesFigure 1