Miracle-dz/UniFAR-FTUs huggingface dataset:
Women's understanding of abnormal cervical smear test results: a qualitative interview study

Abstract Objective: To describe how women interpret their experiences of diagnosis and treatment of a cervical abnormality and how healthcare services for such women can be improved. Design: Qualitative study using detailed individual interviews. Setting: Australian gynaecology clinics. Subjects: 29 Women who had a cervical cytological abnormality and who attended a gynaecologist. Main outcome measures: Women's views on their diagnosis and their information needs. Results: Most women wanted to participate in decisions about their care but found it difficult to get the information they required from doctors because they were confused by what their doctors told them and felt unable to ask questions in the consultation. Medical terms such as wart virus and precancer were difficult to understand. Not being able to see their cervix also made it hard for women to understand what their abnormality meant and what treatment entailed. Most women tried to make sense of their abnormality in the context of their everyday lives. For some women their gynaecological care was not consistent with the way they understood their abnormality. Conclusions: The inherent power structure of medical practice combined with time pressures often make it difficult for doctors to give the detailed information and reassurance patients need when a diagnosis is distressing or when investigation and treatment are strange and upsetting. Key messages Women who have abnormalities detected on cervical smears are confused, afraid, and find it difficult to get the information they require In this study women often assumed that they had cancer because they did not know that smear tests detected precancerous lesions Women needed information about the seriousness of their abnormality, the rationale for treatment, and the precautions recommended after treatment Because the abnormality involved the cervix many women felt their femininity was undermined Women used explanations such as stress, the pill, or sexual activity to make sense of their condition and through these explanations identified things they could do to reduce their risk of cervical cancer
Relationship Between Entropy and Test Data Compression

The entropy of a set of data is a measure of the amount of information contained in it. Entropy calculations for fully specified data have been used to get a theoretical bound on how much that data can be compressed. This paper extends the concept of entropy for incompletely specified test data (i.e., that has unspecified or don't care bits) and explores the use of entropy to show how bounds on the maximum amount of compression for a particular symbol partitioning can be calculated. The impact of different ways of partitioning the test data into symbols on entropy is studied. For a class of partitions that use fixed-length symbols, a greedy algorithm for specifying the don't cares to reduce entropy is described. It is shown to be equivalent to the minimum entropy set cover problem and thus is within an additive constant error with respect to the minimum entropy possible among all ways of specifying the don't cares. A polynomial time algorithm that can be used to approximate the calculation of entropy is described. Different test data compression techniques proposed in the literature are analyzed with respect to the entropy bounds. The limitations and advantages of certain types of test data encoding strategies are studied using entropy theory
BRAK/CXCL14 Is a Potent Inhibitor of Angiogenesis and a Chemotactic Factor for Immature Dendritic Cells

BRAK/CXCL14 is a CXC chemokine constitutively expressed at the mRNA level in certain normal tissues but absent from many established tumor cell lines and human cancers. Although multiple investigators cloned BRAK, little is known regarding the physiologic function of BRAK or the reason for decreased expression in cancer. To understand the possible significance associated with loss of BRAK mRNA in tumors, we examined the pattern of BRAK protein expression in normal and tumor specimens from patients with squamous cell carcinoma (SCC) of the tongue and used recombinant BRAK (rBRAK) to investigate potential biological functions. Using a peptide-specific antiserum, abundant expression of BRAK protein was found in suprabasal layers of normal tongue mucosa but consistently was absent in tongue SCC. Consistent with previous in situ mRNA studies, BRAK protein also was expressed strongly by stromal cells adjacent to tumors. In the rat corneal micropocket assay, BRAK was a potent inhibitor of in vivo angiogenesis stimulated by multiple angiogenic factors, including interleukin 8, basic fibroblast growth factor, and vascular endothelial growth factor. In vitro, rBRAK blocked endothelial cell chemotaxis at concentrations as low as 1 nmol/L, suggesting this was a major mechanism for angiogenesis inhibition. Although only low affinity receptors for BRAK could be found on endothelial cells, human immature monocyte-derived dendritic cells (iDCs) bound rBRAK with high affinity (i.e., Kd, ∼2 nmol/L). Furthermore, rBRAK was chemotactic for iDCs at concentrations ranging from 1 to 10 nmol/L. Our findings support a hypothesis that loss of BRAK expression from tumors may facilitate neovascularization and possibly contributes to immunologic escape.
Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes

Objectives Anxiety is associated with elevated levels of the inflammatory cytokine interleukin-6 (IL-6) and an increased risk for diseases with an inflammatory aetiology. In cancer, higher levels of IL-6 have been associated with increased expression of the epigenetic enzymes DNMT1 and Enhancer of Zeste Homolog 2 (EZH2). However, the relationship between IL-6 and DNA methyltransferases (DNMTs) and EZH2 expression has not previously been examined in anxious individuals. Methods Global DNA methylation levels were measured using the Methylflash Methylated DNA Quantification Kit and gene expression levels of the DNMT and EZH2 genes in anxious (n=25) and nonanxious individuals (n=22) were compared using quantitative real-time PCR. Specifically, we investigated whether global DNA methylation or aberrant expression of these genes was correlated with IL-6 mRNA and protein serum levels in anxious individuals. Results Anxious participants had significantly higher levels of global DNA methylation compared with controls (P=0.001). There were no differences in the mean mRNA expression levels of the DNMT1/3A/3B, EZH2 and IL-6 genes in anxious individuals compared with controls. However, the expression of DNMT1/3A, EZH2 and IL-6 genes increases with increasing Hospital Anxiety and Depression Scale-Anxiety scores in the anxious cohort only. Interestingly, IL-6 gene expression was correlated strongly with DNMT1/3A/3B and EZH2 expression, highlighting a potential relationship between IL-6 and important epigenetic regulatory enzymes. Conclusion This study provides novel insight into the relationship between anxiety, epigenetics and IL-6. Moreover, our findings support the hypothesis that changes in DNA methylation profiles may contribute to the biology of anxiety.
Saturn's equinoctial auroras

We present the first images of Saturn's conjugate equinoctial auroras, obtained in early 2009 using the Hubble Space Telescope. We show that the radius of the northern auroral oval is ∼1.5° smaller than the southern, indicating that Saturn's polar ionospheric magnetic field, measured for the first time in the ionosphere, is ∼17% larger in the north than the south. Despite this, the total emitted UV power is on average ∼17% larger in the north than the south, suggesting that field‐aligned currents (FACs) are responsible for the emission. Finally, we show that individual auroral features can exhibit distinct hemispheric asymmetries. These observations will provide important context for Cassini observations as Saturn moves from southern to northern summer.
Litter accumulation promotes dominance of invasive species of cattails (Typha spp.) in Lake Ontario wetlands

Wetlands of the Great Lakes region are increasingly dominated by invasive cattails (Typha angustifolia andTypha Xglauca) which form dense stands of live and dead biomass that may reduce plant diversity. We hypothesized that differences in plant litter accumulation explain cattail dominance under certain hydrologic regimes related to wetland hydrogeologic setting. We investigated cattail abundance, litter accumulation, and species density in three bayside wetlands hydrologically connected and three protected wetlands hydrologically isolated from Lake Ontario. Mean litter biomass was higher in bayside wetlands (1.7–2.6 vs. 0.4–1.2 kg/m2) and negatively related to species density (p = 0.004) in both settings. A litter addition experiment demonstrated that fallen litter negatively influenced seedling survival (p = 0.061) and species density (p = 0.024). Decomposition rates accounted only partially for higher overall litter accumulation in bayside wetlands. Growing season water levels in bayside wetlands tracked Lake Ontario levels and showed less variation than protected wetlands. More stable water levels and higher density of standing dead stems in bayside wetlands may limit litter fragmentation, resulting in greater litter accumulation. Thus, anthropogenic and natural factors affecting cattail litter production, fragmentation, and decomposition could influence species diversity in coastal wetlands.
Effect of Sodium Nitrate and Nitrate Reducing Bacteria on In vitro Methane Production and Fermentation with Buffalo Rumen Liquor

Nitrate can serve as a terminal electron acceptor in place of carbon dioxide and inhibit methane emission in the rumen and nitrate reducing bacteria might help enhance the reduction of nitrate/nitrite, which depends on the type of feed offered to animals. In this study the effects of three levels of sodium nitrate (0, 5, 10 mM) on fermentation of three diets varying in their wheat straw to concentrate ratio (700:300, low concentrate, LC; 500:500, medium concentrate, MC and 300:700, high concentrate, HC diet) were investigated in vitro using buffalo rumen liquor as inoculum. Nitrate reducing bacteria, isolated from the rumen of buffalo were tested as a probiotic to study if it could help in enhancing methane inhibition in vitro. Inclusion of sodium nitrate at 5 or 10 mM reduced (p<0.01) methane production (9.56, 7.93 vs. 21.76 ml/g DM; 12.20, 10.42 vs. 25.76 ml/g DM; 15.49, 12.33 vs. 26.86 ml/g DM) in LC, MC and HC diets, respectively. Inclusion of nitrate at both 5 and 10 mM also reduced (p<0.01) gas production in all the diets, but in vitro true digestibility (IVTD) of feed reduced (p<0.05) only in LC and MC diets. In the medium at 10 mM sodium nitrate level, there was 0.76 to 1.18 mM of residual nitrate and nitrite (p<0.01) also accumulated. In an attempt to eliminate residual nitrate and nitrite in the medium, the nitrate reducing bacteria were isolated from buffalo adapted to nitrate feeding and introduced individually (3 ml containing 1.2 to 2.3×106 cfu/ml) into in vitro incubations containing the MC diet with 10 mM sodium nitrate. Addition of live culture of NRBB 57 resulted in complete removal of nitrate and nitrite from the medium with a further reduction in methane and no effect on IVTD compared to the control treatments containing nitrate with autoclaved cultures or nitrate without any culture. The data revealed that nitrate reducing bacteria can be used as probiotic to prevent the accumulation of nitrite when sodium nitrate is used to reduce in vitro methane emissions.
William Stanley Jevons and The Coal Question

William Stanley Jevons (1835-1882) est connu en tant qu'economiste britannique, pionnier de l'economie neoclassique contemporaine, avec sa theorie de la valeur subjective basee sur l'utilite marginale. Mais Jevons fut egalement un des pionniers de l'economie de l'environnement et de l'energie. Son ouvrage The coal question souleva des questions fondamentales en matiere d'efficacite energetique et d'economie de carburant
The 2D:4D digit ratio is not a useful marker for prenatal famine exposure: Evidence from the Dutch hunger winter families study

Objectives: Digit lengths, and in particular the ratio of the 2nd (2D) to 4th (4D) digit (2D:4D), are stable in adulthood and have been linked to characteristics thought to have developmental origins, but little research has focused on early life determinants of these measures. We examined whether exposure to acute famine during specific periods of gestation was associated with 2D, 4D or the 2D:4D ratio.
Multi-Modal Route Planning

We examine the computation of optimal paths, which consist of using public transportation, walking and taking a car. A challenge in itself is to determine concise and diverse sets of paths. We consider metropolises like New York, where a fast computation of the paths is difficult. We exemplify that multiple optimality criteria are necessary to obtain diverse sets of paths. This extends the set of optimal paths severely, whereas many paths are similar. To determine concise sets, we study different methods of filtering. We propose a filtering procedure, Types aNd Thresholds (TNT), which leads to the desired sets. To reduce the high computation times, we introduce several optimality-preserving and heuristic ideas. We experimentally evaluate the found paths with respect to quality and computation time. The experiments show the claimed quality of TNT and that the running time, while accepting a fraction of suboptimal solutions, is in the magnitude of few seconds. We complete the paper by giving an outline of possible improvements.
The TRPv1 receptor is a mediator of the exercise pressor reflex in rats

The skeletal muscle exercise pressor reflex (EPR) induces increases in heart rate (HR) and mean arterial pressure (MAP) during physical activity. This reflex is activated during contraction by stimulation of afferent fibres responsive to mechanical distortion and/or the metabolic by‐products of skeletal muscle work. The molecular mechanisms responsible for activating these afferent neurons have yet to be identified. It has been reported that activation of the transient receptor potential vanilloid 1 (TRPv1) receptor within skeletal muscle (localized to unmyelinated afferent fibres) elicits increases in MAP and HR similar to those generated by the EPR. Thus, we hypothesized that stimulation of the TRPv1 receptor during muscle contraction contributes to the activation of the EPR. The EPR was activated by electrically induced static muscle contraction of the hindlimb in decerebrate Sprague–Dawley rats (n= 61) before and after the administration of the TRPv1 receptor antagonists, capsazepine (Capz; 100 μg/100 μl), iodoresinaferatoxin (IRTX; 1 μg/100 μl), or Ruthenium Red (RR; 100 μg/100 μl). Static muscle contraction alone induced increases in both HR (8 ± 2 bpm) and MAP (21 ± 3 mmHg). The HR and MAP responses to contraction were significantly lower (P < 0.05) after the administration of Capz (2 ± 1 bpm; 7 ± 1 mmHg, respectively), IRTX (3 ± 2 bpm; 5 ± 3 mmHg, respectively) and RR (0 ± 1, bpm; 5 ± 2 mmHg, respectively). These data suggest that the TRPv1 receptor contributes importantly to activation of the EPR during skeletal muscle contraction in the rat.
Mutual Exclusion with O(log^2 Log n) Amortized Work

This paper presents a new algorithm for mutual exclusion in which each passage through the critical section costs amortized O(log^2 log n) RMRs with high probability. The algorithm operates in a standard asynchronous, local spinning, shared memory model with an oblivious adversary. It guarantees that every process enters the critical section with high probability. The algorithm achieves its efficient performance by exploiting a connection between mutual exclusion and approximate counting.
Relative increase in choline in the occipital cortex in chronic fatigue syndrome

Puri BK, Counsell SJ, Zaman R, Main J, Collins AG, Hajnal JV, Davey NJ. Relative increase in choline in the occipital cortex in chronic fatigue syndrome. Acta Psychiatr Scand 2002: 106: 224–226. © Blackwell Munksgaard 2002.
Versican is expressed in the proliferating zone in the epidermis and in association with the elastic network of the dermis

The expression of the large chondroitin sulfate proteoglycan versican was studied in human adult skin. For this purpose, bacterial fusion proteins containing unique portions of the versican core protein were prepared. Polyclonal antibodies against the fusion proteins specifically reacted with versican from a proteoglycan fraction of MG63 osteosarcoma cells. In immunohistochemical experiments, the affinity- purified antibodies localized versican in the stratum basale of the epidermis, as well as in the papillary and reticular layers of the dermis. An apparent codistribution of versican with the various fiber forms of the elastic network of the dermis suggested an association of versican with microfibrils. Both dermal fibroblasts and keratinocytes expressed versican in culture during active cell proliferation. In line with the observation that versican is absent in the suprabasal layers of the epidermis where keratinocytes terminally differentiate, culture conditions promoting keratinocyte differentiation induced a down- regulation of versican synthesis. In Northern blots versican mRNA could be detected in extracts from proliferating keratinocytes and dermal fibroblasts. Comparison of RNA preparations from semi-confluent and confluent fibroblast cultures demonstrated decreasing amounts of versican mRNA at higher cell densities. This inverse correlation of versican expression and cell density was confirmed by indirect immunofluorescence staining of cultured fibroblasts and keratinocytes. The localization of versican in the basal zone of the epidermis as well as the density dependence of versican in cell cultures suggest a general function of versican in cell proliferation processes that may not solely be confined to the skin.
Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique

A modified comparative genomic hybridization (mCGH) technique was applied to a series of 17 primary breast carcinomas in which cytogenetic study (CG) demonstrated the presence of homogeneously staining region(s), suggesting the occurrence of DNA amplification. mCGH demonstrated recurrent amplifications of the whole chromosome arms 8q (9 times) and I q (7 times) and of DNA loci in the following bands: 11 q 13 (6 times), 9p 13 and 17q21.1 (4 times), I q21.1 and 16p 11.2 (3 times), and 8q22, 8q24.1, 10q22, 15q26, 17q23, and 20q 13.3 (twice). Amplification of whole chromosome arms is likely to have resulted from unbalanced translocations or isochromosomes, whereas amplifications of smaller chromosomal segments probably arose through real DNA amplification processes. In all tumors but one, more than one amplified locus was detected. The fact that many chromosomal sites were involved suggests that the process of amplification is complex and that many genes are potential targets. Genes Chromosom Cancer 10:160–170 (1994). © 1994 Wiley‐Liss, Inc.
Overexpression of Prox‐1 gene in omental adipose tissue and adipocytes compared with subcutaneous adipose tissue and adipocytes in healthy patients

Adipogenesis is the biological process that controls the development of adipocytes, and is one of the most well studied models of cellular differentiation. In the last decade the study of regulation of human adipogenesis was useful to understand this process, in order to reduce disease such as obesity and diabetes. Prox1 is a transcription factor related to Drosophila Prospero homeobox gene, that plays a major role in the development of central nervous system, liver and pancreas. Prox1 is one of the genes that control the embryonic development and differentiation of the lymphatic system. In this study we decided to analyze the gene expression of Prox‐1 in fragments of human adipose tissue (subcutaneous and omental) and in human adipocytes isolated from omental and subcutaneous tissue. Our results show Prox‐1 is always expressed in adipose tissue and overexpressed in omental adipocytes compared with subcutaneous adipocytes. These preliminary observations confirm a strong correlation of blood vessel development and adipogenesis.
Visual response augmentation in cat (and macaque) LGN: potentiation by corticofugally mediated gain control in the temporal domain

Visual responses of neurons are dependent on the context of a stimulus, not only in spatial terms but also temporally, although evidence for temporally separate visual influences is meagre, based mainly on studies in the higher cortex. Here we demonstrate temporally induced elevation of visual responsiveness in cells in the lateral geniculate nucleus (LGN) of cat and monkey following a period of high intensity (elevated contrast) stimulation. This augmentation is seen in 40–70% (monkey–cat) of cells tested and of all subtypes. Peaking at ∼ 3 min following the period of intense stimulation, it can last for 10–12 min and can be repeated and summed in time. Furthermore, it is dependent on corticofugal input, is seen even when high contrast stimuli of orthogonal orientation are used and therefore results from a/any prior increase in activity in the retino‐geniculo‐striate pathway. We suggest that this reflects a general mechanism for control of visual responsiveness; both a flexible and dynamic means of changing effectiveness of thalamic activity as visual input changes, but also a mechanism which is an emergent property of the thalamo‐cortico‐thalamic loop.
Allergic Contact Dermatitis to Gamma‐Irradiated WEBCOL Alcohol Prep Pads

Abstract: We report a case of allergic contact dermatitis to WEBCOL® alcohol prep pads in a healthy 17‐year‐old girl who showed no reaction to the individual components of the prep pads upon provocative use testing. Although several case reports have described allergic contact dermatitis to isopropyl alcohol, there have been no reports of allergic contact dermatitis to alcohol prep pads sterilized with gamma irradiation, a common sterilization technique capable of producing volatile products in this type of alcohol prep pad.
Automatic generation of subword units for speech recognition systems

Large vocabulary continuous speech recognition (LVCSR) systems traditionally represent words in terms of smaller subword units. Both during training and during recognition, they require a mapping table, called the dictionary, which maps words into sequences of these subword units. The performance of the LVCSR system depends critically on the definition of the subword units and the accuracy of the dictionary. In current LVCSR systems, both these components are manually designed. While manually designed subword units generalize well, they may not be the optimal units of classification for the specific task or environment for which an LVCSR system is trained. Moreover, when human expertise is not available, it may not be possible to design good subword units manually. There is clearly a need for data-driven design of these LVCSR components. In this paper, we present a complete probabilistic formulation for the automatic design of subword units and dictionary, given only the acoustic data and their transcriptions. The proposed framework permits easy incorporation of external sources of information, such as the spellings of words in terms of a nonideographic script.