Miracle-dz/UniFAR-FTUs huggingface dataset:
MIGRATION IN FAR WEST NEPAL

In Nepal, international labor migration to India and overseas, as well as internal migration to the rural Nepalese lowlands, is of high socioeconomic significance. Scholarly debates about migration in Nepal have gradually shifted from an economic to a more holistic perspective, also incorporating social dimensions. However, little evidence has been generated about internal migration to urban destinations and the potential linkages between international and internal migration. This article draws on Bourdieu's “Theory of Practice” and sees migration as a social practice. Accordingly, migration practice is regarded as a strategy social agents apply to increase or transfer capitals and ultimately secure or improve their social position. Evidence for this argument is based on a qualitative case study of ruralto- urban migrants in Far West Nepal conducted in July and August 2009. The study at hand addresses linkages between internal and international migration practices and provides insight about a social stratum that is often neglected in migration research: the middle class and, more precisely, government employees. The authors show that social relations are crucial for channeling internal migration to a specific destination. Furthermore, they unveil how internal migration is connected to the international labor migration of former generations. Finally, the authors examine how migration strategies adopted over generations create multi-local social networks rooted in the family's place of origin.
Rotation of Jets from Young Stars: New Clues from the Hubble Space Telescope Imaging Spectrograph

We report findings from the first set of data in a current survey to establish conclusively whether jets from young stars rotate. We observed the bipolar jets from the T Tauri stars TH 28 and RW Aur and the blueshifted jet from T Tauri star LkHα 321, using the Hubble Space Telescope Imaging Spectrograph. Forbidden emission lines show distinct and systematic velocity asymmetries of 10-25 (±5) km s-1 at a distance of 0. ″3 from the source, representing a (projected) distance of ≈40 AU along the jet in the case of RW Aur, ≈50 AU for TH 28, and 165 AU in the case of LkHα 321. These velocity asymmetries are interpreted as rotation in the initial portion of the jet where it is accelerated and collimated. For the bipolar jets, both lobes appear to rotate in the same direction. Values obtained were in agreement with the predictions of MHD disk-wind models. Finally, we determine, from derived toroidal and poloidal velocities, values for the distance from the central axis of the footpoint for the jet's low-velocity component of ≈0.5-2 AU, consistent with the models of magnetocentrifugal launching.
Food Safety in the Domestic Environment: An Interdisciplinary Investigation of Microbial Hazards During Food Preparation

It has been established that, to a considerable extent, the domestic hygiene practices adopted by consumers can result in a greater or lesser microbial load in prepared meals. In the research presented here, an interdisciplinary study is reported in which interviews, observations of consumers preparing a recipe, and microbial contamination of the finished meals were compared. The results suggest that, while most consumers are knowledgeable about the importance of cross‐contamination and heating in preventing the occurrence of foodborne illness, this knowledge is not necessarily translated into behavior. The adoption of habitual cooking practices may also be important. Potentially risky behaviors were, indeed, observed in the domestic food preparation environment. Eighteen of the participants made errors in food preparation that could potentially result in cross‐contamination, and seven participants allowed raw meat juices to come in contact with the final meal. Using a tracer microorganism the log reduction as a result of consumer preparation was estimated at an average of log 4.1 cfu/salad. When combining these findings, it was found that cross‐contamination errors were a good predictor for log reduction. Procedural food safety knowledge (i.e., knowledge proffered after general open questions) was a better predictor of efficacious bacterial reduction than declarative food safety knowledge (i.e., knowledge proffered after formal questioning). This suggests that motivation to prepare safe food was a better indicator of actual behavior than knowledge about food safety per se.
RDFNet: RGB-D Multi-level Residual Feature Fusion for Indoor Semantic Segmentation

In multi-class indoor semantic segmentation using RGB-D data, it has been shown that incorporating depth feature into RGB feature is helpful to improve segmentation accuracy. However, previous studies have not fully exploited the potentials of multi-modal feature fusion, e.g., simply concatenating RGB and depth features or averaging RGB and depth score maps. To learn the optimal fusion of multimodal features, this paper presents a novel network that extends the core idea of residual learning to RGB-D semantic segmentation. Our network effectively captures multilevel RGB-D CNN features by including multi-modal feature fusion blocks and multi-level feature refinement blocks. Feature fusion blocks learn residual RGB and depth features and their combinations to fully exploit the complementary characteristics of RGB and depth data. Feature refinement blocks learn the combination of fused features from multiple levels to enable high-resolution prediction. Our network can efficiently train discriminative multi-level features from each modality end-to-end by taking full advantage of skip-connections. Our comprehensive experiments demonstrate that the proposed architecture achieves the state-of-the-art accuracy on two challenging RGB-D indoor datasets, NYUDv2 and SUN RGB-D.
Arabidopsis MDA1, a Nuclear-Encoded Protein, Functions in Chloroplast Development and Abiotic Stress Responses

Most chloroplast and mitochondrial proteins are encoded by nuclear genes, whose functions remain largely unknown because mutant alleles are lacking. A reverse genetics screen for mutations affecting the mitochondrial transcription termination factor (mTERF) family in Arabidopsis thaliana allowed us to identify 75 lines carrying T-DNA insertions. Two of them were homozygous for insertions in the At4g14605 gene, which we dubbed MDA1 (MTERF DEFECTIVE IN Arabidopsis1). The mda1 mutants exhibited altered chloroplast morphology and plant growth, and reduced pigmentation of cotyledons, leaves, stems and sepals. The mda1 mutations enhanced salt and osmotic stress tolerance and altered sugar responses during seedling establishment, possibly as a result of reduced ABA sensitivity. Loss of MDA1 function caused up-regulation of the RpoTp/SCA3 nuclear gene encoding a plastid RNA polymerase and modified the steady-state levels of chloroplast gene transcripts. Double mutant analyses indicated that MDA1 and the previously described mTERF genes SOLDAT10 and RUG2 act in different pathways. Our findings reveal a new role for mTERF proteins in the response to abiotic stress, probably through perturbed ABA retrograde signalling resulting from a disruption in chloroplast homeostasis.
Prenatal detection and mapping of a distal 8p deletion associated with congenital heart disease

We report the prenatal diagnosis, at 18 weeks' gestational age of a del(8)(p23.1→pter) in a fetus with an atrio‐ventricular canal, persistent left superior vena cava and hypoplastic right ventricle detected by sonographic imaging. We further refine the breakpoints associated with this defect using fluorescent in situ hybridization analysis (FISH). Our findings correlate with recent reports of the localization and importance of GATA4 (a zinc finger transcription factor) in cardiac development. Though microcephaly, mental retardation and typical behavioural features are well described in various deletions in 8p, the absence of notable microcephaly in this case raises the possibility for a separate genetic aetiology for some of these features. Indeed, primary autosomal recessive microcephaly (MCPH1) was recently mapped to a nearby region and may be the cause for this frequent observation in some cases of 8p deletions. These observations illustrate the role of FISH in prenatal diagnosis and refinement of chromosomal breakpoints. In addition, mappings of loci significant for cardiac development are presented. Our findings suggest that some features of the 8p deletion syndrome may ultimately be uncoupled from one another, and underscore the need for further study of this region of chromosome 8, in order to achieve adequate information for genetic counselling. Copyright © 1999 John Wiley & Sons, Ltd.
IL-4-Independent Inhibition of IL-12 Responsiveness During Leishmania amazonensis Infection1

Leishmania amazonensis induces a nonhealing infection in C3H mice, whereas infection with Leishmania major is self-healing. We found that C3H mice infected with L. amazonensis exhibited decreased IL-12 production, which could account for the susceptibility to this organism. However, exogenous IL-12 administration failed to induce a healing immune response. The failure of L. amazonensis-infected C3H mice to respond to IL-12 was associated with a specific defect in IL-12 receptor β2 (IL-12Rβ2) mRNA expression by CD4+ T cells. Furthermore, decreased IL-12Rβ2 mRNA expression correlated with a decrease in the IL-12-signaling capacity of the lymph node (LN) cells. IL-4 did not contribute to susceptibility or down-regulation of the IL-12Rβ2 subunit, because IL-4−/− mice remained susceptible to L. amazonensis infection, even after IL-12 administration, and CD4+ cells from infected IL-4−/− mice also had reduced expression of IL-12Rβ2 mRNA. These results demonstrate that regulation of the IL-12 receptor, independent of IL-4, is a point of control for the immune response to leishmaniasis. In contrast to experimental L. major infections, where host genetics control susceptibility, these studies demonstrate that the lack of IL-12 responsiveness may be dictated by the pathogen, rather than the host.
Sell Recommendations , Market Sentiment , and Analyst Credibility 1

We find that market reactions to an analyst’s earnings forecasts are weaker when conditioned on the number of prior sell recommendations that the analyst makes for other firms that he follows. This effect is most prominent in periods of high market sentiment (e.g., the 1997-2001 period) and is stronger for glamour firms. This effect does not arise from sell recommendations being a proxy for lower quality analysts. Our results are consistent with the idea that investors suffer from a behavioral bias, where optimistic investors assign lower credibility to analysts who make sell recommendations because such recommendations run counter to investors’ ex ante optimistic beliefs. Our results suggest that analysts may have been subject to a collective market pressure to hype stocks, and that those analysts that held contrarian views by issuing sell recommendations were likely to be sidelined. Consistent with this view, we find that analysts issue fewer sell recommendations when market sentiment is high. JEL Code: G19
Association of IRGM Gene Mutations with Inflammatory Bowel Disease in the Indian Population

Background Mutations in the IRGM gene have been associated with Crohn's disease in several populations but have not been explored in Indian patients with this disease. This study examined the association of IRGM mutations with ulcerative colitis and Crohn's disease in Indian patients with inflammatory bowel disease. Methods The IRGM gene was amplified in four segments and Sanger-sequenced in 101 participants (42 Crohn's disease, 39 ulcerative colitis, and 20 healthy controls). Ten single nucleotide polymorphisms (SNP) were genotyped in 1200 participants (352 Crohn's disease, 400 ulcerative colitis, and 448 healthy controls) using Sequenom MassARRAY iPLEX. Disease associations were evaluated for each of the ten SNPs. Results Thirty one mutations were identified in the IRGM gene, of which two had not hitherto been reported (150226250- ss947429272 & 150227858- ss947429273). Ten SNPs (6 from the above and 4 from the literature) were evaluated. Significant associations with Crohn's disease were noted with the T allele of rs1000113 (OR 1.46, 95% CI 1.12–1.90), T allele of rs9637876 (OR 1.25, 95% CI 1.005–1.561) and C allele of rs 13361189 (OR 1.33, 95% CI 1.07–1.669). Two SNPs – rs11747270 and rs180802994 – did not exhibit Hardy-Weinberg equilibrium but were associated with both Crohn's disease and ulcerative colitis in this population. The remaining SNPs did not show significant associations with either Crohn's disease or ulcerative colitis. Conclusions Association of IRGM gene SNPs with Crohn's disease is reported for the first time in Indian patients. We also report, for the first time, an association of rs 9637876 in the IRGM gene with Crohn's disease.
Gibrat’s Law for Cities Revisited

The aim of this work is to test empirically the validity of Gibrat's Law in the growth of cities, using data for all the twentieth century of the complete distribution of cities (without any size restrictions) in three countries: the US, Spain and Italy. For this we use different techniques (parametric and non-parametric methods), obtaining mixed evidence. Our results confirm that Gibrat's law for means holds only as a long-run average. In the short term, considered decade by decade, we find that growth was divergent in all three countries. Despite this, the distribution of growth in the cities can be approached as a lognormal. In the long term, panel data unit root tests confirm the validity of Gibrat's Law in the upper tail distribution. Finally we find evidence in favour of a weak Gibrat's Law (size affects the variance of the growth process but not its mean) when using non-parametric methods which relate the growth rate to city size.
Exploitation of Cosmo-Skymed image time series for snow monitoring in alpine regions

The main aim of this work is to adapt the ratio-technique for snow cover mapping developed for C-band to the X-band and high resolution COSMO-SkyMed images. This algorithm, aimed at detecting wet snow, is based on the difference in backscattering coefficients between snow-covered areas in winter images and snow-free summer images. For these purposes, a series of COSMO-SkyMed acquisitions (Stripmap PingPong mode, dual polarizations VV-VH) has been planned and acquired over the test site located in South Tyrol (Northern Italy) in correspondence of the melting and winter season. Contemporary to radar passes field campaigns have been performed. The objective is to test the sensitivity of X-band data to different snow conditions. An analysis has been carried out to find the most suitable filtering technique which allows a clearer distinction of distributions of backscattering coefficients of snow-covered and snow-free areas. Based on this analysis a first map of snow from the images acquired on 26–27 April 2010 (wet snow) was derived and compared with snow cover area derived from LANDSAT ETM+ of 20-04-2010 based on NDSI. Further statistical analysis will be carried out also considering the new acquisitions.
Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo.

INTRODUCTION Epimedium species (aka horny goat weed) have been utilized for the treatment of erectile dysfunction in Traditional Chinese Medicine for many years. Icariin (ICA) is the active moiety of Epimedium species. AIM To evaluate the penile hemodynamic and tissue effects of ICA in cavernous nerve injured rats. We also studied the in vitro effects of ICA on cultured pelvic ganglia. METHODS Rats were subjected to cavernous nerve injury and subsequently treated for 4 weeks with daily gavage feedings of a placebo solution of normal saline and Dimethyl sulfoxide (DMSO) vs. ICA dissolved in DMSO at doses of 1, 5, and 10 mg/kg. A separate group underwent a single dose of ICA 10 mg/kg 2 hours prior to functional testing. Functional testing with cavernous nerve stimulation and real-time assessment of intracavernous pressure (ICP) was performed at 4 weeks. After functional testing, penile tissue was procured for immunohistochemistry and molecular studies. In separate experiments, pelvic ganglia were excised from healthy rats and cultured in the presence of ICA, sildenafil, or placebo culture media. MAIN OUTCOME MEASURE Ratio of ICP and area under the curve (AUC) to mean arterial pressure (MAP) during cavernous nerve stimulation of subject rodents. We also assayed tissue expression of neuronal nitric oxide synthase (nNOS), eNOS: endothelial nitric oxide synthase (eNOS), calponin, and apoptosis via immunohistochemistry and Western blot. Serum testosterone and luteinizing hormone (LH) were assayed using enzyme-linked immunosorbant assay (ELISA). Differential length of neurite outgrowth was assessed in cultured pelvic ganglia. RESULTS Rats treated with low-dose ICA demonstrated significantly higher ICP/MAP and AUC/MAP ratios compared with control and single-dose ICA animals. Immunohistochemistry and Western blot were revealing of significantly greater positivity for nNOS and calponin in penile tissues of all rats treated with ICA. ICA led to significantly greater neurite length in cultured specimens of pelvic ganglia. CONCLUSION ICA may have neurotrophic effects in addition to known phosphodiesterase type 5 inhibiting effects.
Dynamic Gene-Resource Landscape Management of Norway Spruce: Combining Utilization and Conservation

Traditional gene-resource management programs for forest trees are long-term endeavors requiring sustained organizational commitment covering extensive landscapes. While successful in maintaining adaptation, genetic diversity and capturing traditional growth attributes gains, these programs are dependent on rigid methods requiring elaborate mating schemes, thus making them slow in coping with climate change challenges. Here, we review the significance of Norway spruce in the boreal region and its current management practices. Next, we discuss opportunities offered by novel technologies and, with the use of computer simulations, we propose and evaluate a dynamic landscape gene-resource management in Norway. Our suggested long-term management approach capitalizes on: (1) existing afforestation activities, natural crosses, and DNA-based pedigree assembly to create structured pedigree for evaluation, thus traditional laborious control crosses are avoided and (2) landscape level genetic evaluation, rather than localized traditional progeny trials, allowing for screening of adapted individuals across multiple environmental gradients under changing climate. These advantages lead to greater genetic response to selection in adaptive traits without the traditional breeding and testing scheme, facilitating conservation of genetic resources within the breeding population of the most important forest tree species in Norway. The use of in situ selection from proven material exposed to realistic conditions over vast territories has not been conducted in forestry before. Our proposed approach is in contrast to worldwide current programs, where genetic evaluation is constrained by the range of environments where testing is conducted, which may be insufficient to capture the broad environmental variation necessary to tackle adaptation under changing climate.
The effect of grade configuration on the academic achievement of special needs students: The case of New Jersey

For over thirty years, research has been conducted on the relative benefits of integrating the sixth through eighth grades within the structure of the K-8 elementary school or of establishing a freestanding middle school structure. While the available research clearly supports the positive effects ofthe K-8 structure on academic achievement in the middle grades, there has been little study explicitly of students classified as "special needs. " This study analyzes the effects of the K-8 versus 6-8 grade configurations on the proficiency rates for sixth and eighth grade special education scores on the 2011 NJ ASK in Math and Language Arts. K-8 and 6-8 configured schools' mean scores were compared in Math and Language Arts to determine if K-8 schools' performance was significantly different than 6-8 schools. Analysis was also conducted for schools that were situated in similar district factor groups so as to account for socioeconomic status. A two-way ANOV A was performed to see if the variables grade configuration and district factor group had an individual and/or a combined interaction effect on special education proficiency rates. To further examine the grade configurations' effect on the dependent variable proficiency rates for special education students, a hierarchical multiple regression was conducted. Within this regression, the independent variable of grade configuration was examined to see if its effects were different after controlling for the variables total school size, mobility rate, economic disadvantage, and percentage of special education students within a school. Finally, the proportion of variance in achievement attributable to the independent and control variables in sixth and eighth grade was compared to determine if there was any difference in their influence on proficiency rates by grade level.
Molecular phylogeny of Calyptratae (Diptera: Brachycera): the evolution of 18S and 16S ribosomal rDNAs in higher dipterans and their use in phylogenetic inference

Sequences for nearly complete 18S rRNA and partial 16S rRNA genes were determined for sixteen species representing twelve calyptrate families. Two unique insertions are present in expansion regions of the 18S rDNA in nycteribiids. Alignments containing other dipteran rRNA genes provided good resolution at higher taxonomic level: monophyly of Calyptratae is well supported. While both 16S and 18S rDNA matrices produce unstable topologies within Calyptratae when analysed separately, their combination results in a tree with several robust and well supported nodes. Of three superfamilies recognized in recent classifications, the Hippoboscoidea is well supported by 16S rDNA and by combined matrices. The representatives of Muscoidea, Musca sp. and Antipoda sp. , display a tendency to cluster within Oestroidea. The comparison of secondary structures of two variable regions indicates that Sarcophagidae are related to Calliphoridae rather than to Tachinidae.
Channel Hot Carrier Stress on Irradiated 130-nm NMOSFETs

We investigate how X-ray exposure impact the long term reliability of 130-nm NMOSFETs as a function of device geometry and irradiation bias conditions. This work focuses on electrical stresses on n-channel MOSFETs performed after irradiation with X-ray up to 136 Mrad(SiO2) in different bias conditions. Irradiation is shown to negatively affect the degradation during subsequent hot carrier injection. Increasing the bias during irradiation slightly reduces the impact on following electrical stress in core MOSFETs. Through device simulations, we attribute these effects to an enhanced impact ionization at the bulk-STI interfaces due to radiation-induced trapped charge and defects.
Numeracy in Science.

Understanding in science relies heavily on an ability to handle mathematical concepts confidently. Research has shown that numeracy is an important area for pupils to develop. This article looks at some of the key areas in science that are at risk if pupils are not numerate. It may be that some of these difficulties arise through not distinguishing between the teaching of facts and skills and teaching through conceptual understanding. Suggestions as to how this problem might be addressed are discussed.