Miracle-dz/UniFAR-FTUs huggingface dataset:
Species differences in vasopressin receptor binding are evident early in development: Comparative anatomic studies in prairie and montane voles

Monogamous prairie voles (Microtus ochrogaster) and promiscuous montane voles (Microtus montanus) exhibit remarkable differences in the distribution of vasopressin (AVP) receptors in the adult brain. This difference in receptor distribution is associated with species differences in the behaviors, including pair bond formation and paternal care, found selectively in the monogamous vole. To investigate a potential mechanism for this species difference in AVP receptors, the present study examined the ontogeny of receptor binding in the two species to determine whether the adult maps arose from a shared pattern in development. By using 125I‐linear‐AVP, which is a selective high‐affinity ligand for the V1a receptor, we found early appearance and transient expression of AVP receptor binding during postnatal development in both species. However, the ontogenetic patterns of regional AVP receptor binding were species specific. In the diagonal band, the bed nucleus of the stria terminalis, and the central nucleus of the amygdala, prairie voles had higher AVP receptor binding at birth than montane voles, and this difference persisted with little variation into adulthood. In these areas, therefore, species differences in AVP receptor binding appeared to be determined primarily by genetic or prenatal factors. In the lateral septum, both species had low levels of AVP receptor binding at birth. Thereafter, the binding increased rapidly in montane voles, but it remained unchanged in prairie voles. In the cingulate cortex, AVP receptor binding in prairie voles showed a peak in early development with a subsequent decline and reached the adult level at weaning, whereas the binding in montane voles remained unchanged into adulthood. A similar but opposite pattern was found in the frontoparietal cortex, in which AVP receptor binding showed an early peak in montane voles but did not change significantly in prairie voles. These results demonstrate that 1) species differences in regional AVP receptor binding are evident in the early postnatal period and, in several areas, may be determined by genetic or prenatal factors, and 2) AVP may target brain areas differently in infant and adult prairie and montane voles and, thus, could exert differential effects on the organization of the central nervous system in the two species of voles. J. Comp. Neurol. 378:535–546, 1997. © 1997 Wiley‐Liss, Inc.
Telehealth Experiential Learning: A Pilot Study of The Client’s Experience

This research examined the client experience of a student-led occupational therapy pro bono clinic that involved telehealth-delivered treatment sessions. Six clients responded to a survey that included both Likert scale close-ended and open-ended items. The researchers employed descriptive statistics for close-ended items and summarized open-ended responses. All close-ended items had a median score of 4 out of 5, indicating it was easy to communicate, easy to find and use features of the software, and that there were minimal problems with the software in the telehealth delivered sessions. Open ended-responses reflected an overall positive experience.
Toward an Efficient Deep Pipelined Template-Based Architecture for Accelerating the Entire 2-D and 3-D CNNs on FPGA

3-D convolutional neural networks (3-D CNNs) are used efficiently in many computer vision applications. Most previous work in this area has concentrated only on design and optimization of accelerators for 2-D CNNs, with few attempts having been made to accelerate 3-D CNNs on FPGA. We find the acceleration of 3-D CNNs on FPGA to be challenging due to their high computational complexity and storage demands. More importantly, although the computational patterns of 2-D and 3-D CNNs are analogous, the conventional approaches that have been adopted for acceleration of 2-D CNNs may be unfit for 3-D CNN acceleration. In this paper, in order to accelerate 2-D and 3-D CNNs using a uniform framework, we first propose a uniform template-based architecture that uses templates based on the Winograd algorithm to ensure the rapid development of 2-D and 3-D CNN accelerators. Then, with the aim of efficiently mapping all layers of 2-D /3-D CNNs onto a pipelined accelerator, techniques are developed to improve the throughput and computational efficiency of the accelerator, including layer fusion, layer clustering, and workload-balancing scheme. Finally, we demonstrate the effectiveness of the deep pipelined architecture by accelerating real-life 2-D and 3-D CNNs on the state-of-the-art FPGA platform. On VCU118, we achieve 3.7 TOPS for VGG-16, which outperforms state-of-the-art FPGA-based CNN accelerators. Comparisons with CPU and GPU solutions demonstrate that our implementation of 3-D CNN achieves gains of up to <inline-formula> <tex-math notation="LaTeX">$17.8\times $ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$64.2\times $ </tex-math></inline-formula> in performance and energy relative to a CPU solution, and a <inline-formula> <tex-math notation="LaTeX">$5.0\times $ </tex-math></inline-formula> energy efficiency gain over a GPU solution.
Effects of Recreation on Animals Revealed as Widespread through a Global Systematic Review

Outdoor recreation is typically assumed to be compatible with biodiversity conservation and is permitted in most protected areas worldwide. However, increasing numbers of studies are discovering negative effects of recreation on animals. We conducted a systematic review of the scientific literature and analyzed 274 articles on the effects of non-consumptive recreation on animals, across all geographic areas, taxonomic groups, and recreation activities. We quantified trends in publication rates and outlets, identified knowledge gaps, and assessed evidence for effects of recreation. Although publication rates are low and knowledge gaps remain, the evidence was clear with over 93% of reviewed articles documenting at least one effect of recreation on animals, the majority of which (59%) were classified as negative effects. Most articles focused on mammals (42% of articles) or birds (37%), locations in North America (37.7%) or Europe (26.6%), and individual-level responses (49%). Meanwhile, studies of amphibians, reptiles, and fish, locations in South America, Asia, and Africa, and responses at the population and community levels are lacking. Although responses are likely to be species-specific in many cases, some taxonomic groups (e.g., raptors, shorebirds, ungulates, and corals) had greater evidence for an effect of recreation. Counter to public perception, non-motorized activities had more evidence for a negative effect of recreation than motorized activities, with effects observed 1.2 times more frequently. Snow-based activities had more evidence for an effect than other types of recreation, with effects observed 1.3 times more frequently. Protecting biodiversity from potentially harmful effects of recreation is a primary concern for conservation planners and land managers who face increases in park visitation rates; accordingly, there is demand for science-based information to help solve these dilemmas.
German lexical personality factors: relations with the HEXACO model

We correlated the scales of the HEXACO Personality Inventory (HEXACO‐PI) with adjective scale markers of factors previously obtained in indigenous lexical studies of personality structure in the German language. Self‐ratings obtained from a sample of 323 German participants showed a pattern of strong convergent and weak discriminant correlations, supporting the content‐based interpretation of the German lexical factors in terms of the HEXACO dimensions. Notably, convergent correlations were strong for both the broader and the narrower variants of the Honesty‐Humility factor as observed in German lexical studies. Also, convergent correlations for HEXACO Openness to Experience were, as expected, stronger for German adjectives describing a creative and intellectual orientation than for German adjectives describing intellectual ability. Copyright © 2006 John Wiley & Sons, Ltd.
Putative Bioactive Motif of Tritrpticin Revealed by an Antibody with Biological Receptor-Like Properties

Antimicrobial peptides represent one of the most promising future strategies for combating infections and microbial drug resistance. Tritrpticin is a 13mer tryptophan-rich cationic antimicrobial peptide with a broad spectrum of activity whose application in antimicrobial therapy has been hampered by ambiguity about its biological target and consequently the molecular interactions necessary for its antimicrobial activity. The present study provides clues about the mechanism of action of tritripticin by using a unique monoclonal antibody (mAb) as a ‘physiological’ structural scaffold. A pool of mAbs were generated against tritrpticin and based on its high affinity and ability to bind tritrpticin analogs, mAb 6C6D7 was selected and characterized further. In a screening of phage displayed random peptides, this antibody was able to identify a novel antimicrobial peptide with low sequence homology to tritrpticin, suggesting that the mAb possessed the physico-chemical characteristics mimicking the natural receptor. Subsequently, thermodynamics and molecular modeling identified a core group of hydrophobic residues in tritrpticin arranged in a distorted’s’ shaped conformation as critical for antibody binding. Comparison of the mAb induced conformation with the micelle bound structure of tritrpticin reveals how a common motif may be able to interact with multiple classes of biomolecules thus extending the target range of this innate immune peptide. Based on the concurrence between thermodynamic and structural data our results reveal a template that can be used to design novel antimicrobial pharmacophores while simultaneously demonstrating at a more fundamental level the potential of mAbs to act as receptor surrogates.
Alzheimer ’ s Association Report 2015 Alzheimer ’ s disease facts and figures Alzheimer ’ s Association *

This report discusses the public health impact of Alzheimer’s disease (AD), including incidence *Email: sciencestaff@ 1552-5260/$ see fron CC BY-NC-ND licens http://dx.doi. org/10.10 and prevalence, mortality rates, costs of care and the overall effect on caregivers and society. It also examines the challenges encountered by health care providers when disclosing an AD diagnosis to patients and caregivers. An estimated 5.3 million Americans have AD; 5.1 million are age 65 years, and approximately 200,000 are age <65 years and have younger onset AD. By mid-century, the number of people living with AD in the United States is projected to grow by nearly 10 million, fueled in large part by the aging baby boom generation. Today, someone in the country develops AD every 67 seconds. By 2050, one new case of AD is expected to develop every 33 seconds, resulting in nearly 1 million new cases per year, and the estimated prevalence is expected to range from 11 million to 16 million. In 2013, official death certificates recorded 84,767 deaths from AD, making AD the sixth leading cause of death in the United States and the fifth leading cause of death in Americans age 65 years. Between 2000 and 2013, deaths resulting from heart disease, stroke and prostate cancer decreased 14%, 23% and 11%, respectively, whereas deaths from AD increased 71%. The actual number of deaths to which AD contributes (or deaths with AD) is likely much larger than the number of deaths from AD recorded on death certificates. In 2015, an estimated 700,000 Americans age 65 years will die with AD, and many of them will die from complications caused by AD. In 2014, more than 15 million family members and other unpaid caregivers provided an estimated 17.9 billion hours of care to people with AD and other dementias, a contribution valued at more than $217 billion. Average per-person Medicare payments for services to beneficiaries age 65 years with AD and other dementias are more than two and a half times as great as payments for all beneficiaries without these conditions, and Medicaid payments are 19 times as great. Total payments in 2015 for health care, long-term care and hospice services for people age 65 years with dementia are expected to be $226 billion. Among people with a diagnosis of AD or another dementia, fewer than half report having been told of the diagnosis by their health care provider. Though the benefits of a prompt, clear and accurate disclosure of an AD diagnosis are recognized by the medical profession, improvements to the disclosure process are needed. These improvements may require stronger support systems for health care providers and their patients.
WEAKLY SELFDUAL KÄHLER SURFACES

We study Kähler surfaces with harmonic anti-selfdual Weyl tensor. We provide an explicit local description, which we use to obtain the complete classification in the compact case. We give new examples of extremal Kähler metrics, including Kähler–Einstein metrics and conformally Einstein Kähler metrics. We also extend some of our results to almost Kähler 4-manifolds, providing new examples of Ricci-flat almost Kähler metrics which are not Kähler.
"It's Farcical!": Theories, Models, and Recommendations to Improve Public Consultations During Ontario School Closure Reviews

iii Acknowledgements . iv List of Tables . x List of Figures . xi 1.0 Introduction . 1 1.1 Research Topic . 2 1.2 Research Questions . 2 1.3 Thesis Structure . 4 1.3.1 Literature Review . 4 1.3. 2 Methods . 4 1.3. 3 Findings and Analysis . 4 1.3. 4 Recommendations and Conclusions . 5 2.0 Literature Review . 6 2.1 Role of Local Schools in Rural Communities . 6 2.2 Planning Ignores Schools . 7 2.3 History of School Closures . 8 2.4 Ontario School Closure Consultation Policies . 10 2.4. 1 2006 Policies . 10 2.4. 2 2009 Policies . 11 2.4. 3 2015 Policies . 12 2.4. 4 2018 Policies . 15 2.5 Criticism of Ontario School Closure Consultation Procedure . 17 2.6 Planning from Top-down to Bottom-up . 17 2.7 Public Consultation Models . 20 2.8 Public Consultation and Engagement Theory . 25 2.8. 1 Why Theory? 26 2.8. 2 Planning’s Consultation Theory . 28 2.8. 3 Habermas and the Communicative Turn in Planning . 31 2.8. 3.1 Habermas’ Theory of Communicative Action . 32
First Detection of Leishmania tropica DNA and Trypanosoma Species in Sergentomyia Sand Flies (Diptera: Psychodidae) from an Outbreak Area of Cutaneous Leishmaniasis in Ghana

Background Leishmania major and an uncharacterized species have been reported from human patients in a cutaneous leishmaniasis (CL) outbreak area in Ghana. Reports from the area indicate the presence of anthropophilic Sergentomyia species that were found with Leishmania DNA. Methodology/Principal Findings In this study, we analyzed the Leishmania DNA positive sand fly pools by PCR-RFLP and ITS1 gene sequencing. The trypanosome was determined using the SSU rRNA gene sequence. We observed DNA of L. major, L. tropica and Trypanosoma species to be associated with the sand fly infections. This study provides the first detection of L. tropica DNA and Trypanosoma species as well as the confirmation of L. major DNA within Sergentomyia sand flies in Ghana and suggests that S. ingrami and S. hamoni are possible vectors of CL in the study area. Conclusions/Significance The detection of L. tropica DNA in this CL focus is a novel finding in Ghana as well as West Africa. In addition, the unexpected infection of Trypanosoma DNA within S. africana africana indicates that more attention is necessary when identifying parasitic organisms by PCR within sand fly vectors in Ghana and other areas where leishmaniasis is endemic.
Effectiveness of robot-assisted gait training on freezing of gait in people with Parkinson disease: evidence from a literature review

The aim of this review was to evaluate, summarize and discuss the available literature concerning the effect of robot-assisted gait training (RAGT) on patient with Parkinson disease (PD) and freezing of gait (FOG). A comprehensive literature search was conducted utilizing of MEDLINE, Embase, Scopus, Web of Science, PEDro (Physiotherapy Evidence Database), and the Cochrane Review. Search terms used in-cluded ‘Parkinson disease,’ ‘Freezing of gait,’ ‘RAGT,’ ‘robot-assisted gait training,’ ‘Locomotor rehabilitation,’ ‘gait trainer,’ and ‘robotics assisted gait training. ’ A total of 4 studies were evaluated, but these studies were primarily of low-level evidence. All the 4 studies noted positive outcomes with using RAGT on FOG. No adverse events or side effects that occurred during and/or after the interventions. While the current literature generally offers support for the use of RAGT for FOG treatment, there is a paucity of strong evidence to support its widespread use. The increasing availability of RAGT technology offers the potential for engaging therapy in FOG rehabilitation, but its utility remains uncertain given the limited studies available at this time.
Rigid-band electronic structure of scandium nitride across the 
n
-type to 
p
-type carrier transition regime

Sanjay Nayak,1,2 Madhusmita Baral,3,4 Mukul Gupta,5 Jaspreet Singh,6 Magnus Garbrecht,7 Tapas Ganguli,3,4 S. M. Shivaprasad,1,2 and Bivas Saha1,2,8,* 1Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India 2International Centre for Materials Science, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India 3Raja Ramanna Centre for Advanced Technology, Indore 452013, India 4Homi Bhabha National Institute, Training school complex, Anushakti Nagar, Mumbai 400094 5UGC-DAE Consortium for Scientific Research, Khandwa Road, Indore-452017, India 6Technical Physics Division, Bhabha atomic research Centre, Mumbai 400094 7Australian Centre for Microscopy and Microanalysis, The University of Sydney, NSW 2006, Australia 8School of Advanced Materials (SAMat), Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India
Working with Edge Emotions as a means for Uncovering Problematic Assumptions: Developing a practically sound theory

The connection between cognition and emotion, and between mind and body, has been well documented by neuroscience. The adult education practitioners of critical reflection and transformative learning processes have understood this more holistic understanding of human nature both empirically and intuitively. However, the key theory of the field, Jack Mezirow’s theory of transformative learning, has been given consistent criticism on its focus on rational and cognitive aspects of learning while understating its emotional and social aspects. Similarly, the conceptualization of the processes of reflection appears more appropriate to sophia than for phronesis. This, as is argued in the paper, leaves the theory rather idealistic while lacking understanding of the prerequisites for, and actualities of reflection. This paper presents a recent theoretical development that is both grounded in the analysis of Mezirow’s theory as well as extending and elaborating the theorization of reflection, by utilizing the insights from neuroscience. The presented theory explicates how cognition and emotion are intertwined in the processes of reflection. Further, the theory offers conceptual basis for further research and practice regarding reflection and transformative learning, not only showing the ideals, but offering conceptual tools to work with the challenges of reflection as well.
Process-Based Organization Design Model: Theoretical Review and Model Conceptualization

The complexity of today's business world is translated into complexity of the company's organization design (Galbraith, 2002). Organizations are forced to quickly adapt to emerging complexity if they want to survive. The change is addressing all areas of business, especially questioning organizational effectiveness and trying to find optimal solutions for doing business. In accordance with requirements, competitive trends are pushing executives to rethink traditional design configurations. Factors such as increased competition in cost, quality and service, and technical change have forced companies not only to seek out new ways of doing old tasks, but also new ways of organizing either old or new tasks (Cross, 1990). Such focus on the flow of work within organizations, but as well as between them, is emphasizing process orientation as a new management paradigm. Inefficiencies of the two most commonly present structures – functional and divisional, in addition to emerging business trends, place the emphasis on a process-based organization as one of the possible solutions. The process-based organization is lead by the process paradigm, which is focused on the horizontal view of business activities and alignment of organizational systems towards business processes. Regardless of a large interest on business processes, existing organization design theory offers only general guidelines for process-based organizations or more precisely, a process-based organization design model. Consequently, the purpose of the paper is to demystify process-based organization design model. By clearly distinguishing between different levels of process orientation, and by addressing characteristics of the chosen model the paper will lead to better understanding of this way of organizing. Eventually, an operationalized model of process-based organization is developed. Furthermore, the paper elaborates on differences between process-based and other organizational structures and philosophies (e.g. functional, product, matrix, project, team-based). Besides structural elements, which will be in the primary focus, the paper will discuss the alignment of all other important organization design elements for process environment (e.g., management style, reward systems, performance metrics, people practices, organizational culture, etc.). There would be proposed necessary adjustments of organizational elements which should be aligned with the process-based structural solution. In such way, some of the blind spots of process-based organization design model would be revealed, providing practical implications for its implementation and ultimately, offering solution for rising business complexity.
A Natural Language Interface to Semantic Web using Modular Query Patterns A complete presentation of the SWIP system

Our purpose is to provide end users with a mean to query graph-based knowledge bases using natural language queries and thus hide the complexity of formulating a query expressed in a graph query language such as SPARQL. The main originality of our approach lies in the use of generic query patterns which are presented in this article and whose exploitation is justified by the literature. We also explain how our approach is designed to be adaptable to different user languages and emphasize the implementation of the approach relying on SPARQL. Evaluations on the QALD data set have shown the relevancy of the approach.
BioJava: an open-source framework for bioinformatics in 2012

Motivation: BioJava is an open-source project for processing of biological data in the Java programming language. We have recently released a new version (3.0.5), which is a major update to the code base that greatly extends its functionality. Results: BioJava now consists of several independent modules that provide state-of-the-art tools for protein structure comparison, pairwise and multiple sequence alignments, working with DNA and protein sequences, analysis of amino acid properties, detection of protein modifications and prediction of disordered regions in proteins as well as parsers for common file formats using a biologically meaningful data model. Availability: BioJava is an open-source project distributed under the Lesser GPL (LGPL). BioJava can be downloaded from the BioJava website (http://www.biojava.org). BioJava requires Java 1.6 or higher. All inquiries should be directed to the BioJava mailing lists. Details are available at http://biojava.org/wiki/BioJava:MailingLists Contact: andreas.prlic@gmail.com