Miracle-dz/UniFAR-FTUs huggingface dataset:
Lateral Alveolar Ridge Expansion in the Anterior Maxilla Using Piezoelectric Surgery for Immediate Implant Placement.

PURPOSE The purpose of this study was to evaluate the efficacy of the ridge-splitting technique in the anterior maxilla, using piezoelectric surgery for immediate implant placement. Study outcomes were compared with those of implant placement in the same patients using the conventional drilling technique. MATERIALS AND METHODS Ten patients received a total of 22 implants in the anterior maxilla, 11 of which were placed using a ridge-splitting procedure (test group) and the other 11 using the conventional drilling procedure (control group). Ridge width (RW), crestal bone level (BL), and implant stability quotient (ISQ) were measured at different points in time. Data were analyzed and compared between the groups using analysis of variance (ANOVA) and paired-sample t tests at a significance level of 5%. RESULTS For the test group, the gain in RW was not stable in time because at 6 months postoperatively, the RW lost some of the initial gain; however, the net gain was still significant. At 6 months postoperatively, BL was similar for both groups. The net bone loss on the mesial aspect and the average of the mesial and the distal measures did not differ significantly between both groups. ISQ values sharply increased at 3 months postoperatively in the test group. All implants met the modified Albrektsson criteria (1989) for success. CONCLUSION The results from this study support the efficacy and safety of ridge expansion using piezoelectric surgery for implant insertion in the anterior maxilla. The modest net gain in bone width suggests that additional hard and soft tissue augmentation may be necessary, especially in the esthetic zone. ISQ values suggest a minimum healing time of 3 months before loading the implants that have been inserted using this ridge-splitting protocol.
Genome-Wide Screening and Identification of New Trypanosoma cruzi Antigens with Potential Application for Chronic Chagas Disease Diagnosis

The protozoan Trypanosoma cruzi is the etiologic agent of Chagas disease, an infection that afflicts approximately 8 million people in Latin America. Diagnosis of chronic Chagas disease is currently based on serological tests because this condition is usually characterized by high anti-T. cruzi IgG titers and low parasitemia. The antigens used in these assays may have low specificity due to cross reactivity with antigens from related parasite infections, such as leishmaniasis, and low sensitivity caused by the high polymorphism among T. cruzi strains. Therefore, the identification of new T. cruzi-specific antigens that are conserved among the various parasite discrete typing units (DTUs) is still required. In the present study, we have explored the hybrid nature of the T. cruzi CL Brener strain using a broad genome screening approach to select new T. cruzi antigens that are conserved among the different parasite DTUs and that are absent in other trypanosomatid species. Peptide arrays containing the conserved antigens with the highest epitope prediction scores were synthesized, and the reactivity of the peptides were tested by immunoblot using sera from C57BL/6 mice chronically infected with T. cruzi strains from the TcI, TcII or TcVI DTU. The two T. cruzi proteins that contained the most promising peptides were expressed as recombinant proteins and tested in ELISA experiments with sera from chagasic patients with distinct clinical manifestations: those infected with T. cruzi from different DTUs and those with cutaneous or visceral leishmaniasis. These proteins, named rTc_11623. 20 and rTc_N_10421. 310, exhibited 94.83 and 89.66% sensitivity, 98.2 and 94.6% specificity, respectively, and a pool of these 2 proteins exhibited 96.55% sensitivity and 98.18% specificity. This work led to the identification of two new antigens with great potential application in the diagnosis of chronic Chagas disease.
Multivariate Multiple Regression Models for a Big Data-Empowered SON Framework in Mobile Wireless Networks

In the 5G era, the operational cost of mobile wireless networks will significantly increase. Further, massive network capacity and zero latency will be needed because everything will be connected to mobile networks. Thus, self-organizing networks (SON) are needed, which expedite automatic operation of mobile wireless networks, but have challenges to satisfy the 5G requirements. Therefore, researchers have proposed a framework to empower SON using big data. The recent framework of a big data-empowered SON analyzes the relationship between key performance indicators (KPIs) and related network parameters (NPs) using machine-learning tools, and it develops regression models using a Gaussian process with those parameters. The problem, however, is that the methods of finding the NPs related to the KPIs differ individually. Moreover, the Gaussian process regression model cannot determine the relationship between a KPI and its various related NPs. In this paper, to solve these problems, we proposed multivariate multiple regression models to determine the relationship between various KPIs and NPs. If we assume one KPI and multiple NPs as one set, the proposed models help us process multiple sets at one time. Also, we can find out whether some KPIs are conflicting or not. We implement the proposed models using MapReduce.
The genomic consequences of adaptive divergence and reproductive isolation between species of manakins

The processes of adaptation and speciation are expected to shape genomic variation within and between diverging species. Here we analyze genomic heterogeneity of genetic differentiation and introgression in a hybrid zone between two bird species (Manacus candei and M. vitellinus) using 59 100 SNPs, a whole genome assembly, and Bayesian models. Measures of genetic differentiation ( FST ) and introgression (genomic cline center [α] and rate [β]) were highly heterogeneous among loci. We identified thousands of loci with elevated parameter estimates, some of which are likely to be associated with variation in fitness in Manacus populations. To analyze the genomic organization of differentiation and introgression, we mapped SNPs onto a draft assembly of the M. vitellinus genome. Estimates of FST , α, and β were autocorrelated at very short physical distances (< 100 bp), but much less so beyond this. In addition, average statistical associations (linkage disequilibrium) between SNPs were generally low and were not higher in admixed populations than in populations of the parental species. Although they did not occur with a constant probability across the genome, loci with elevated FST , α, and β were not strongly co‐localized in the genome. Contrary to verbal models that predict clustering of loci involved in adaptation and isolation in discrete genomic regions, these results are consistent with the hypothesis that genetic regions involved in adaptive divergence and reproductive isolation are scattered throughout the genome. We also found that many loci were characterized by both exceptional genetic differentiation and introgression, consistent with the hypothesis that loci involved in isolation are also often characterized by a history of divergent selection. However, the concordance between isolation and differentiation was only partial, indicating a complex architecture and history of loci involved in isolation.
Changes in snow and glacier cover in an arid watershed of the western Kunlun Mountains using multisource remote-sensing data

Snow and glaciers in the mountain watersheds of the Tarim River basin in western China provide the primary water resources to cover the needs of downstream oases. Remote sensing provides a practical approach to monitoring the change in snow and glacier cover in those mountain watersheds. This study investigated the change in snow and glacier cover in one such mountain watershed using multisource remote-sensing data, including the Moderate Resolution Imaging Spectroradiometer (MODIS), Landsat (Multispectral Scanner (MSS), Thematic Mapper (TM), and Enhanced Thematic Mapper Plus (ETM+)), Corona, and Google EarthTM imagery. With 10 years’ daily MODIS snow-cover data from 2002 to 2012, we used two de-cloud methods before calculating daily snow-cover percentage (SCP), annual snow-cover frequency (SCF), and annual minimum snow-cover percentage (AMSCP) for the watershed. Mann–Kendall analysis showed no significant trend in any of those snow-cover characterizations. With a total of 22 Landsat images from 1967 to 2011, we used band ratio and supervised classification methods for snow classification for Landsat TM/ETM+ images and MSS images, respectively. The Landsat snow-cover data were divided into two periods (1976–2002 and 2004–2011). Statistical tests indicated no significant difference in either the variance or mean of SCPs between the two periods. Three glaciers were identified from Landsat images of 1998 and 2011, and their total area increased by 12.6%. In addition, three rock glaciers were also identified on both the Corona image of 1968 and the Google high-resolution image of 2007, and their area increased by 2.5%. Overall, based on multisource remote-sensing data sets, our study found no evidence of significant changes in snow and glacier cover in the watershed.
Generations of interdisciplinarity in bioinformatics

Bioinformatics, a specialism propelled into relevance by the Human Genome Project and the subsequent -omic turn in the life science, is an interdisciplinary field of research. Qualitative work on the disciplinary identities of bioinformaticians has revealed the tensions involved in work in this “borderland. ” As part of our ongoing work on the emergence of bioinformatics, between 2010 and 2011, we conducted a survey of United Kingdom-based academic bioinformaticians. Building on insights drawn from our fieldwork over the past decade, we present results from this survey relevant to a discussion of disciplinary generation and stabilization. Not only is there evidence of an attitudinal divide between the different disciplinary cultures that make up bioinformatics, but there are distinctions between the forerunners, founders and the followers; as inter/disciplines mature, they face challenges that are both inter-disciplinary and inter-generational in nature.
A New Simple Performance Test Focused on Agility in Elderly People: The Ten Step Test

Background: Not only the reduction of muscle strength or balance, but also the reduction of the agility are regarded as important factors of falls in elderly people. If an agility test for elderly people is established, the precision of the fall prediction rises and can be used for individual training. Objectives: To develop a new performance test focused on agility for elderly people and to evaluate the usefulness of this test. Design: Cross-sectional study. Setting: The Welfare Center of Kagami Town, Kagami Town Office, etc., Kochi, Japan. Participants: 828 community-dwelling, independent adults aged 20–99 years with no obvious cognitive or functional disability, were randomly recruited from Kagami town and the surrounding areas. Measurements: The Ten Step Test (TST, a new performance test), motor reaction time (MRT), knee extensor isometric strength, single leg standing time (SLST), and some other tests were used to evaluate the criterion-related validity and the content validity. TST was developed as a modified version of other step tests which require the subjects to place the whole foot on a block, then return it to the floor. In addition, female participants over 70 were asked whether or not they had fallen in the past year. Results: Excellent reliability for TST was found for interrelation (intra-class correlation coefficients, ICC = 0.96), and re-test reliability was sufficient (ICC = 0.86). Evidence for criterion-related validity was found through high single correlation with the timed supine-to-stand (r = 0.68) and high single correlation with MRT (r = 0.59). In addition, content validity was found through low correlation with knee extensor strength (–0.35) and SLST (–0.36) in 112 women over 70 years of age. The error rate by TST to predict falls (35.2%) was lower than the error rate by muscle strength (44.4%) and the balance (38.7%). TST confirmed decline after 50 years of age, and it conformed to a cubic curve. Conclusion: The findings indicate that TST is a reliable measure of agility, and it can help to predict the risk of falls. The decline of agility accelerates after 50 years of age. It shows that the decline of agility differs from the decline of leg muscle strength and balance.
Shared path protection with differentiated reliability

The authors (Fumagalli and Tacca (2001)) introduced the concept of differentiated reliability (DiR) applied to dedicated path protection (DPP) switching in wavelength division multiplexing (WDM) rings. By means of the DiR concept, a network can be designed to provide multiple degrees of reliability and efficiently satisfy the user-specific requirements, yet minimizing the network total cost. This paper extends the DiR concept to the case of shared path protection (SPP) switching in arbitrary (mesh) topology, the so called SPP-DiR. A time efficient algorithm is proposed to determine the primary and backup path of each demand in both conventional SPP and SPP-DiR (WDM) networks. When compared to DPP, results obtained for the pan-European network by using the proposed algorithm indicate cost reductions of about 16% when SPP is applied, and up to 34% when SPP-DiR is applied.
Assessment of freestanding membranes prepared from Antheraea pernyi silk fibroin as a potential vehicle for corneal epithelial cell transplantation

Freestanding membranes created from Bombyx mori silk fibroin (BMSF) offer a potential vehicle for corneal cell transplantation since they are transparent and support the growth of human corneal epithelial (HCE) cells. Fibroin derived from the wild silkworm Antheraea pernyi (APSF) might provide a superior material by virtue of containing putative cell-attachment sites that are absent from BMSF. Thus we have investigated the feasibility of producing transparent, freestanding membranes from APSF and have analysed the behaviour of HCE cells on this material. No significant differences in cell numbers or phenotype were observed in short term HCE cell cultures established on either fibroin. Production of transparent freestanding APSF membranes, however, proved to be problematic as cast solutions of APSF were more prone to becoming opaque, displayed significantly lower permeability and were more brittle than BMSF-membranes. Cultures of HCE cells established on either membrane developed a normal stratified morphology with cytokeratin pair 3/12 being immuno-localized to the superficial layers. We conclude that while it is feasible to produce transparent freestanding membranes from APSF, the technical difficulties associated with this biomaterial, along with an absence of enhanced cell growth, currently favour the continued development of BMSF as a preferred vehicle for corneal cell transplantation. Nevertheless, it remains possible that refinement of techniques for processing APSF might yet lead to improvements in the handling properties and performance of this material.
Ground‐based measurements of airborne Saharan dust in marine environment during the NAMMA field experiment

Several episodes of airborne mineral dust transported from the Saharan deserts were observed at Sal Island, Cape Verde for 2–28 September 2006 during the NASA African Monsoon Multidisciplinary Analyses (NAMMA) field experiment. Dust particles were mixed with marine background aerosols when the dust layers descended into the marine boundary layer. A new method is developed to derive the optical properties of dust when mixed with maritime aerosols. The derived single scattering albedo and mass scattering efficiency differed significantly between two selected cases leading to differences in their direct radiative effects. Back‐trajectory analyses suggest that the two cases were influenced by dust particles originating from different source regions over North Africa. This stresses the importance of resolving dust optical properties in sub‐regional scales to attain a better assessment of the role of airborne dust on the climate system.
Crustal deformation measurements using repeat‐pass JERS 1 synthetic aperture radar interferometry near the Izu Peninsula, Japan

We have examined the precision of interferometric synthetic aperture radar (SAR) measurements of surface deformation of the Earth using 24-cm wavelength data acquired by the Japanese Earth Resources Satellite 1 (JERS 1) spacecraft, over the Izu Peninsula, Japan. Radar images acquired from 1993 to 1994 were made into 11 independent interferograms. Apparent water vapor signatures with equivalent path delay up to 16 cm preclude reliable estimates of small deformation from only one interferogram. Averaging of interferograms improves the measurement, such that residuals between precise leveling data and corresponding radar observations are less than 1 cm RMS. There is a clear correlation between cloud cover extent on a given day and the spectral power of the water vapor signature in an interferogram formed from the corresponding day's SAR image. Also, several water vapor features associated with local topography are consistent with accumulation of moisture on the windward side of an on-shore flow. Analysis shows that decorrelation in mixed conifer and deciduous forest is a weak function of the time between observations, imposing a roughly constant level of additional decorrelation relative to scatter-stable urban areas. Furthermore, in high-relief areas, correlation is high when the baseline is tens of meters but drops rapidly with increasing baseline length. With strict control of the interferometric baseline length, adequate correlation in interferograms over very long time periods is possible even in forested, high relief regions. Observed inflation over Ito city is consistent with a localized magma source at depth, suggesting a different mechanism from the previous episode in 1989.
Low-Complexity Distributed Scheduling Algorithms for Wireless Networks

We consider the problem of designing distributed scheduling algorithms for wireless networks. We present two algorithms, both of which achieve throughput arbitrarily close to that of maximal schedules, but whose complexity is low due to the fact that they do not necessarily attempt to find maximal schedules. The first algorithm requires each link to collect local queue-length information in its neighborhood, and its complexity is otherwise independent of the size and topology of the network. The second algorithm, presented for the node-exclusive interference model, does not require nodes to collect queue-length information even in their local neighborhoods, and its complexity depends only on the maximum node degree in the network.
Studies on the Vanadium-Catalyzed Nonoxidative Depolymerization of Miscanthus giganteus-Derived Lignin

Lignin samples isolated from Miscanthus giganteus using organosolv processes were treated with vanadium catalysts that were previously developed in our group. We demonstrate that the catalyst with high β-O-4' bond-cleaving activity in dimeric lignin models was also effective in depolymerizing actual lignin. Molecular weight-lowering was evidenced by gel permeation chromatography (GPC), whereas 2D NMR experi- ments showed that β-O-4' linkages were selectively cleaved in the degradation process, just as in the case of lignin models. Monophenolic degradation products were also formed, and the individual molecules were identified and quantified by GC/MS.
BOLD Contrast on a 3 T Magnet: Detectability of the Motor Areas

To predict the potential and the limitations of functional MRI (fMRI) with a very high field magnet, the detectability and reproducibility of activation were evaluated by comparing the activation induced by a sequential finger movement task at 1.5 T with that at 3 T. The detectability of the premotor area, supplementary motor area (SMA), and ipsilateral sensorimotor area (SM1) showed significant improvement at 3 T. On the other hand, the detectability of contralateral SM1 was not significantly different between 1.5 and 3 T. The degree of activation was proportional to task demand in the ipsilateral SM1 and SMA, whereas that in the contralateral SM1 and SMA was not. FMRI with a 3 T magnet has greater potential for detection of neuronal activation as a functional network. These observations indicated that task demand and static magnetic field strength should be considered in interpretation of fMRI data for clinical usage.
Neurological manifestations of Ehlers-Danlos syndrome(s): A review

The term “Ehlers-Danlos syndrome” (EDS) groups together an increasing number of heritable connective tissue disorders mainly featuring joint hypermobility and related complications, dermal dysplasia with abnormal skin texture and repair, and variable range of the hollow organ and vascular dysfunctions. Although the nervous system is not considered a primary target of the underlying molecular defect, recently, increasing attention has been posed on neurological manifestations of EDSs, such as musculoskeletal pain, fatigue, headache, muscle weakness and paresthesias. Here, a comprehensive overview of neurological findings of these conditions is presented primarily intended for the clinical neurologist. Features are organized under various subheadings, including pain, fatigue, headache, stroke and cerebrovascular disease, brain and spine structural anomalies, epilepsy, muscular findings, neuropathy and developmental features. The emerging picture defines a wide spectrum of neurological manifestations that are unexpectedly common and potentially disabling. Their evaluation and correct interpretation by the clinical neurologist is crucial for avoiding superfluous investigations, wrong therapies, and inappropriate referral. A set of basic tools for patient’s recognition is offered for raising awareness among neurologists on this underdiagnosed group of hereditary disorders.
Response Time of Forested Mountainous Watersheds in Humid Regions

This study proposes an analytical method for the estimation of time lag for forested mountainous watersheds. The water flow in a watershed is separated and analyzed in two phases, the land or hillslope phase and the stream channel phase. In many areas around the globe the flow in a forested high gradient watershed is generated through subsurface pathways as several field experiments have shown. The kinematic wave theory is used to describe the generation of flow from steep forested hillslopes. This hillslope runoff is, then, used as input to the stream channels. The equations were developed by assuming kinematic conditions in the stream channel and that the stream slope and the roughness coefficient i) vary according to a second order polynomial with the distance from the mouth of the watershed, ii) vary linearly with the distance from the outlet of the watershed, and iii) are constant throughout the watershed. Comparison of the results of the proposed equation with data from two experimental watersheds in Coastal British Columbia indicates that the three expressions of the proposed equation, even the simplest one assuming constant stream slope and roughness coefficient, are reliable and give good approximation of the observed time lag.