Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of harsh physical discipline and developmental outcomes in adolescence

A history of exposure to harsh physical discipline has been linked to negative outcomes for children, ranging from conduct disorder to depression and low self-esteem. The present study extends this work into adolescence, and examines the relationship of lifetime histories of harsh discipline to adolescents' internalizing and externalizing symptoms and to their developing capacities for establishing autonomy and relatedness in family interactions. Adolescent and parent reports of harsh discipline, independently coded observations of conflictual interactions, and adolescent reports of symptoms were obtained for 141 adolescents at age 16. Both parents' use of harsh discipline was related to greater adolescent depression and externalizing behavior, even when these effects were examined over and above the effects of other parenting measures known to account for these symptoms. Adolescents exposed to harsh discipline from mothers were also less likely to appear warm and engaged during an interaction task with their mothers. It is suggested that a history of harsh discipline is associated not only with social and emotional functioning, but also with the developmental task of autonomy and relatedness.This study and its write-up were supported by grants from the National Institute of Mental Health (R01-MH44934 and R01-MH58066).
Axotomy-induced changes in the expression of a type III neuronal intermediate filament gene

The effect of axotomy on the expression of the 57 kDa neuronal intermediate filament (IF) protein in adult rat dorsal root ganglion (DRG) neurons was examined. This IF protein is known to have an exclusively neuronal localization but is considerably more limited in its distribution in the nervous system than the neurofilament (NF) triplet proteins. The 57 kDa neuronal IF protein is similar (and perhaps identical) to the protein “peripherin” and is known to be the product of a Type III IF gene. Since the down-regulated expression of NF proteins (products of type IV IF genes) has been well established, it was of interest to determine whether the novel 57 kDa IF protein was regulated in a similar or different manner from that of the NFs in axotomized neurons. In vitro pulse-labeling of DRGs with 35S- methionine: cysteine followed by 2-dimensional gel electrophoresis/fluorography revealed that the synthesis of the 57 kDa neuronal IF protein was increased 2 weeks after sciatic nerve crush. Immunocytochemical studies using a polyclonal antibody to the 57 kDa neuronal IF protein showed that the immunodetectable levels of this protein increased in DRG neurons after peripheral axotomy. In the normal DRG, staining was localized almost exclusively to small-sized neurons. At 2 weeks after axotomy, however, large- and medium-sized neurons also became immunoreactive; in addition, the overall level of staining in the DRG was greater than normal. Quantitative analysis of in situ hybridizations of DRG neurons with a 35S-labeled cDNA probe specific for the 57 kDa neuronal IF protein revealed a significant increase in the level of 57 kDa IF mRNA in the large-sized (greater than 1000 microns2) neurons 2 weeks after axotomy; the level of 57 kDa IF mRNA in the small neurons was not different from normal at that time. Finally, using a newly developed paradigm for examining the composition of regenerating axons by axonal transport, we determined that significant amounts of the 57 kDa neuronal IF protein were conveyed into the regrowing axonal sprouts of DRG neurons. When DRG neurons were conditioned by a previous axotomy (a crush axotomy of the distal sciatic nerve 2 weeks earlier) and then stimulated to regenerate axons by a second crush axotomy located very close to the DRG, the regenerating sprouts incorporated and conveyed significantly more 57 kDa IF protein by slow axonal transport than did those elaborated by unprimed DRG neurons. (ABSTRACT TRUNCATED AT 400 WORDS)
The hB-tree: a multiattribute indexing method with good guaranteed performance

A new multiattribute index structure called the hB-tree is introduced. It is derived from the K-D-B-tree of Robinson [15] but has additional desirable properties. The hB-tree internode search and growth processes are precisely analogous to the corresponding processes in B-trees [1]. The intranode processes are unique. A k-d tree is used as the structure within nodes for very efficient searching. Node splitting requires that this k-d tree be split. This produces nodes which no longer represent brick-like regions in k-space, but that can be characterized as holey bricks, bricks in which subregions have been extracted. We present results that guarantee hB-tree users decent storage utilization, reasonable size index terms, and good search and insert performance. These results guarantee that the hB-tree copes well with arbitrary distributions of keys.
VCSEL-based miniature laser-Doppler interferometer

There are many applications for non-contact measurement of the displacement and velocity of moving objects, especially when achieved at low cost. An optical displacement sensor has been developed that can be compared to expensive laser-interferometry sensors, however at a cost compatible with requirements for consumer products. This miniature Laser-Doppler Interferometer works on all light scattering surfaces. The first large-scale application is in PC-mice. The measurement principle employs so-called "Laser Self Mixing", which occurs when laser light scattered on a surface, within the coherence length, is coupled back into the laser cavity. When the object is moving, the back-scattered light is continuously shifting in phase relative to the laser light at the laser mirror. This results in a periodic perturbation of the feedback into the laser cavity, which causes modulations of the light intensity in the cavity. The frequency of these modulations is proportional the speed of the object. A VCSEL, optimized for this application, is used as light source, a photo-diode in the sensor measures the intensity fluctuations and, finally, an integrated circuit transfers the photo-diode signal into velocity or displacement information. To determine the direction of the movement, a triangle modulation of the laser-current is used, which modulates the laser-temperature and hence the laser frequency. Next to the applications in PC-mice a much wider range of applications as input device in consumer products can be envisaged. For instance menu navigation by finger movement over a sensor in remote controls, mobile phones and lap tops. Furthermore a wide field of applications is envisaged in the manufacturing of industrial equipment, which requires non-contact measurement of the movement of materials. The small form factor of less than 0.2 cubic centimeters allows applications previously considered impossible.
Wnt5a Is Associated with Cigarette Smoke-Related Lung Carcinogenesis via Protein Kinase C

Wnt5a is overexpressed during the progression of human non-small cell lung cancer. However, the roles of Wnt5a during smoking-related lung carcinogenesis have not been clearly elucidated. We investigated the associations between Wnt5a and the early development of cigarette smoke related lung cancer using human bronchial epithelial (HBE) cells (NHBE, BEAS-2B, 1799, 1198 and 1170I) at different malignant stages established by exposure to cigarette smoke condensate (CSC). Abnormal up-regulation of Wnt5a mRNA and proteins was detected in CSC-exposed transformed 1198 and tumorigenic 1170I cells as compared with other non-CSC exposed HBE cells. Tumor tissues obtained from smokers showed higher Wnt5a expressions than matched normal tissues. In non-CSC exposed 1799 cells, treatment of recombinant Wnt5a caused the activations of PKC and Akt, and the blockage of Wnt5a and PKC significantly decreased the viabilities of CSC-transformed 1198 cells expressing high levels of Wnt5a. This reduced cell survival rate was associated with increased apoptosis via the down-regulation of Bcl2 and the induction of cleaved poly ADP-ribose polymerase. Moreover, CSC-treated 1799 cells showed induction of Wnt5a expression and enhanced colony-forming capacity. The CSC-induced colony forming efficiency was suppressed by the co-incubation with a PKC inhibitor. In conclusion, these results suggest that cigarette smoke induces Wnt5a-coupled PKC activity during lung carcinogenesis, which causes Akt activity and anti-apoptosis in lung cancer. Therefore, current study provides novel clues for the crucial role of Wnt5a in the smoking-related lung carcinogenesis.
Optimal compensation for neuron death

The brain has an impressive ability to withstand neural damage. Diseases that kill neurons can go unnoticed for years, and incomplete brain lesions or silencing of neurons often fail to produce any effect. How does the brain compensate for such damage, and what are the limits of this compensation? We propose that neural circuits optimally compensate for neuron death, thereby preserving their function as much as possible. We show that this compensation can explain changes in tuning curves induced by neuron silencing across a variety of systems, including the primary visual cortex. We find that optimal compensation can be implemented through the dynamics of networks with a tight balance of excitation and inhibition, without requiring synaptic plasticity. The limits of this compensatory mechanism are reached when excitation and inhibition become unbalanced, thereby demarcating a recovery boundary, where signal representation fails and where diseases may become symptomatic.
Do middle school students really have fixed images of elders?

OBJECTIVE The purpose of this study was to determine whether combinations of characteristics, abstracted from drawings of elders made by middle school students, grouped together to form cohesive perceptions, or stereotypes, of human aging. METHODS We abstracted 49 characteristics from drawings of elders made by 1,944 students at two middle schools in San Antonio, Texas, at the beginning of the 1998-1999 school year. Correlational and factor analyses were used to determine if there was an underlying structure or grouping to the characteristics. Logistic regression was used to determine the variables associated with the investigators' classification of the images as positive, neutral, or negative. RESULT The standardized alpha coefficient for the 49 variables was low (alpha = 0.37). The Spearman rho correlations between the variables were also low, with 90.2% of the 1,176 comparisons being < 0.10. Exploratory factor analyses did not provide a useful grouping of characteristics drawn by the students, including analyses stratified by gender and restricted to the most common 34 characteristics. Among the 49 characteristics that emerged from the drawings, 11, 4, and 11 traits were directly associated with classifying the drawings as positive, neutral, or negative, respectively. DISCUSSION These analyses indicate that middle school students have not formed strong images regarding aging: No clear cohesive stereotypes of elders emerged from the images drawn by these children. Absence of stereotypic views implies that middle school students may not have a built-in bias toward older people and age-associated changes. This suggests that young adolescents are at a point where instruction including gerontological content can be used to effectively teach about aging and health promotion.
Health-Related Quality of Life in Chinese Patients with Mild and Moderately Active Ulcerative Colitis

Background Ulcerative colitis (UC) impairs the health-related quality of life (HRQOL). The difference in HRQOL between patients with mild and moderately active UC is not well-defined. Few studies have been conducted to explore the factors that influence HRQOL in Chinese patients. Our study aims were to (1) compare HRQOL of mildly active UC patients with moderate patients; (2) explore the factors that influence HRQOL in Chinese patients with UC; and (3) analyze demographic and disease characteristics of UC in China. Methods A total of 110 mild and 114 moderate patients with UC were enrolled. The demographic and disease characteristics were recorded. HRQOL was measured by the Chinese version of the inflammatory bowel disease questionnaire (IBDQ) between mild and moderate patients, male and female patients, and different disease distributions. Stepwise regression analysis was used to assess factors influencing the IBDQ score. Results Patients with moderate UC had significantly lower IBDQ total scores compared to patients with mild UC (P=0.001). The IBDQ total score had a negative correlation with the Mayo score (r=–0.263, P<0.001). Stepwise regression analysis showed that the disease activity index and gender had an influence on the IBDQ total score (P<0.05). The female patients had a lower score than the male patients (P<0.05), especially in the emotional function domain (P=0.002). Different disease distributions were not statistically significant in the IBDQ total score (P=0.183). Conclusions UC has a negative influence on HRQOL. HRQOL in patients with moderate UC was lower than HRQOL in patients with mild UC, as measured by the IBDQ. UC disease activity has a negative correlation with HRQOL. Gender and the disease activity index are important factors involved in the impairment of HRQOL in Chinese patients with UC. Chinese females may benefit from increased psychological care as part of UC therapy.
Association between anti-HBc positivity and hepatocellular carcinoma in HBsAg-negative subjects with chronic liver disease

AbstractA meta-analysis was performed to ascertain to what extent hepatitis B surface antigen (HBsAg)-negative/anti-hepatitis B core (anti-HBc)-positive subjects with chronic liver disease are at a higher risk of developing hepatocellular carcinoma (HCC) than the anti-HBc-negative.All studies included had to fulfill the following characteristics and inclusion criteria: they investigated the relationship between HBsAg-negative/anti-HBc-positive serology and the occurrence of HCC, whether a case–control or cohort study, they provided relative risk (RR) or odds ratios (ORs) and 95% confidence intervals (CIs), were available as a full text written in English, and were published and indexed up to April 2015.Twenty-six original studies met the inclusion criteria, allowing a meta-analysis on 44,553 patients. The risk of HCC among the 9986 anti-HBc-positive subjects was 67% higher than in the 34,567 anti-HBc-negative (95% CI = 1.44–1.95, P < 0.0001). The results were similar when groups of patients with a different stage of liver disease (patients with chronic liver disease, patients with cirrhosis), with different ethnicity (Asian and non-Asian) and etiology (HCV and non-HCV) were considered. The risk of HCC was significantly higher in the 651 anti-HBs/anti-HBc-positive patients (RR = 1.36; 95% CI = 1.17–1.58, P = 0.03) and in the 595 anti-HBs-negative/anti-HBc-positive subjects (RR = 2.15; 95% CI = 1.58–2.92, P < 0.0001) than in the 1242 anti-HBs/anti-HBc negative. However, the RR from 8 studies indicated that the risk of HCC was 35% lower among the anti-HBs/anti-HBc-positive subjects compared to the anti-HBs-negative/anti-HBc-positive (RR = 0.65; 95% CI = 0.52–0.8, P < 0.0001). This meta-analysis shows that in HBsAg-negative subjects with chronic liver disease, anti-HBc positivity is strongly associated with the presence of HCC, an association observed in all subgroups according to the stage of the disease, etiology, and ethnicity.
Particle Swarm Optimization-based LS-SVM for Building Cooling Load Prediction

Accurate predicting of building cooling load has been one of the most important issues in the energy-saving building, which provides an approach to integrate and optimize the heating, ventilating, and air-conditioning (HVAC) system cooling supply system efficiently. Because of the remarkable nonlinear mapping capabilities of forecasting, artificial neural networks have played a crucial role in forecasting building cooling load, but suffer from the phenomena of local minimum and over-fitting. This paper investigates the feasibility of using Least Squares Support vector regression (LS-SVR) to forecast building cooling load. LS-SVR is a novel type of learning machine, which has been successfully employed to solve nonlinear regression and time series problems. Due to the importance of parameters optimization in LS-SVR model, particle swarm optimization (PSO) was used to optimize the model parameters. The experiment results show that PSO can quickly obtain the optimal parameters satisfying the precision requirement with a simple calculation, which solves the problem of complex calculation and empiricism in conventional methods. The evaluation on the testing cases shows the SVR model with PSO has a good generalization performance and can be a promising alternative for building cooling load prediction.
Pharmacogenetic Predictors of Outcome in Patients with Stage II and III Colon Cancer Treated with Oxaliplatin and Fluoropyrimidine-Based Adjuvant Chemotherapy

Identifying molecular markers for tumor recurrence is critical in successfully selecting patients with colon cancer who are more likely to benefit from adjuvant chemotherapy. We investigated the effect of single-nucleotide polymorphisms (SNP) within genes involved in oxaliplatin and fluoropyrimidines metabolism, DNA repair mechanisms, drug transport, or angiogenesis pathways on outcome for patients with stage II and III colon cancer treated with adjuvant chemotherapy. Genomic DNA was extracted from formalin-fixed paraffin-embedded samples of 202 patients with stage II and III colon cancer receiving oxaliplatin-based adjuvant chemotherapy from January 2004 to December 2009. Genotyping was performed for 67 SNPs in 32 genes using the MassARRAY (SEQUENOM) technology. Our results were validated in an independent cohort of 177 patients treated with the same chemotherapy regimens. The combination of the selectin E (SELE) rs3917412 G>A G/G and the methylentetrahydrofolate reductase (MTHFR) rs1801133 T/T genotypes was associated with a significantly increased risk for recurrence in both the training [RR = 4.103; 95% confidence interval (CI), 1.803–9.334; P = 0.001] and the validation cohorts (RR = 3.567; 95% CI, 1.253–10.151; P = 0.017) in the multiple regression analysis considering the stage, lymphovascular invasion, and bowel perforation as covariates. The combined analysis of these polymorphisms was also significantly associated with overall survival in both cohorts (RR = 3.388; 95% CI, 0.988–11.623; P = 0.052, and RR = 3.929; 95% CI, 1.144–13.485; P = 0.020, respectively). Our findings suggest that the SELE rs3917412 and MTHFR rs1801133 SNPs could serve as pharmacogenetic predictors of tumor recurrence in patients with early-stage colon cancer treated with oxaliplatin-based adjuvant chemotherapy, thus allowing personalized selection of treatment to optimize clinical outcomes. Mol Cancer Ther; 13(9); 2226–37. ©2014 AACR.
Oxidative Stress in Chronic Kidney Disease

Chronic kidney disease (CKD) is associated with a high risk for cardiovascular and all-cause mortality and premature aging [1, 2]. Already in 2002, Himmelfarb et al. suggested that oxidative stress is a “unifying concept of cardiovascular disease in uremia” [3]. For several years now, researchers and clinicians in nephrology have been working on the proof and extension of this concept, on refining and arguing its details, and on the desired implementation of respective therapies and biomarkers. The present special issue aims to inform the readership on latest developments on various aspects of oxidative stress research in CKD and to foster further research in the field.
Prefrontal and Striatal Activity Related to Values of Objects and Locations

The value of an object acquired by a particular action often determines the motivation to produce that action. Previous studies found neural signals related to the values of different objects or goods in the orbitofrontal cortex, while the values of outcomes expected from different actions are broadly represented in multiple brain areas implicated in movement planning. However, how the brain combines the values associated with various objects and the information about their locations is not known. In this study, we tested whether the neurons in the dorsolateral prefrontal cortex (DLPFC) and striatum in rhesus monkeys might contribute to translating the value signals between multiple frames of reference. Monkeys were trained to perform an oculomotor intertemporal choice in which the color of a saccade target and the number of its surrounding dots signaled the magnitude of reward and its delay, respectively. In both DLPFC and striatum, temporally discounted values (DVs) associated with specific target colors and locations were encoded by partially overlapping populations of neurons. In the DLPFC, the information about reward delays and DVs of rewards available from specific target locations emerged earlier than the corresponding signals for target colors. Similar results were reproduced by a simple network model built to compute DVs of rewards in different locations. Therefore, DLPFC might play an important role in estimating the values of different actions by combining the previously learned values of objects and their present locations.
Learning your language, outside-in and inside-out

Abstract Children learn how to learn language, and they get better as they go along. This article presents an overview of research inspired by a dynamic systems view of language learning that shows it to be a self-organizing process in which children create the units they need from the regularities present in the environment in which they are situated.
Assessment of Teachers' Exposure to Noise in Selected Primary Schools

The assessment of teachers' exposure to noise in primary schools was carried out on the basis of: questionnaire studies (covering 187 teachers in 3 schools), noise measurements at the teachers' workplaces, measurements of the school rooms acoustic properties (reverberation time and speech transmission index STI in 72 classrooms), analysis of statistical data regarding hazards and occupational diseases in the education sector. The studies have shown that noise is the main factor of annoyance in the school environment. Over 50% of questioned teachers consider noise as annoying and near 40% as very annoying or unbearable. A-weighted equivalent continuous sound pressure levels measured in classrooms, teacher rooms and common rooms are in the range of 58-80 dB and they exceed 55 dB (criteria of noise annoyance). The most frequently reported subjective feelings and complaints (over 90%) are: growth of psychical and emotional tension, irritation, difficulties in concentrating, hoarseness, cough. Noise in schools is also a harmful factor. High A-weighted equivalent continuous sound pressure levels ranging from 80 to 85 dB, measured in corridors during pauses and in sports halls, can cause the risk of hearing damage among PE teachers and persons oversensitive to noise. The latter concerns both teachers and pupils. High background noise levels (55-65 dB) force teachers to raise their voice. It can lead to the development of an occupational disease - chronic voice disorders due to excessive vocal effort lasting for at least 15 years. In the education sector 785 new cases of this disease were reported only in 2008. Poor acoustics in classrooms (reverberation time ranging from 0.8 to 1.7 s, STI<0.6 in 50% of classrooms) have an adverse influence on speech reception and make the teaching and learning processes difficult.