Miracle-dz/UniFAR-FTUs huggingface dataset:
0 . 20 , 0 . 40 ) ceramics by high-energy x-ray diffraction and Raman spectroscopy

High-resolution x-ray diffraction (XRD), Raman spectroscopy and total scattering XRD coupled to atomic pair distribution function (PDF) analysis studies of the atomic-scale structure of archetypal BaZrx Ti1−x O3 (x = 0.10, 0.20, 0.40) ceramics are presented over a wide temperature range (100–450 K). For x = 0.1 and 0.2 the results reveal, well above the Curie temperature, the presence of Ti-rich polar clusters which are precursors of a long-range ferroelectric order observed below TC. Polar nanoregions (PNRs) and relaxor behaviour are observed over the whole temperature range for x = 0.4. Irrespective of ceramic composition, the polar clusters are due to locally correlated off-centre displacement of Zr/Ti cations compatible with local rhombohedral symmetry. Formation of Zr-rich clusters is indicated by Raman spectroscopy for all compositions. Considering the isovalent substitution of Ti with Zr in BaZrx Ti1−x O3, the mechanism of formation and growth of the PNRs is not due to charge ordering and random fields, but rather to a reduction of the local strain promoted by the large difference in ion size between Zr4+ and Ti4+. As a result, non-polar or weakly polar Zr-rich clusters and polar Ti-rich clusters are randomly distributed in a paraelectric lattice and the long-range ferroelectric order is disrupted with increasing Zr concentration.
Trivializing The Energy Landscape Of Deep Networks

We study a theoretical model that connects deep learning to finding the ground state of the Hamiltonian of a spherical spin glass. Existing results motivated from statistical physics show that deep networks have a highly non-convex energy landscape with exponentially many local minima and energy barriers beyond which gradient descent algorithms cannot make progress. We leverage a technique known as topology trivialization where, upon perturbation by an external magnetic field, the energy landscape of the spin glass Hamiltonian changes dramatically from exponentially many local minima to "total trivialization", i.e., a constant number of local minima. There also exists a transitional regime with polynomially many local minima which interpolates between these extremes. We show that a number of regularization schemes in deep learning can benefit from this phenomenon. As a consequence, our analysis provides order heuristics to choose regularization parameters and motivates annealing schemes for these perturbations.
Cytologic differential diagnostic problems in ulcerative cervicitis.

OBJECTIVE To improve the detection rates in the determination of signs consistent with ulcerative cervicitis against signs of intraepithelial neoplasia, in PAP smears. STUDY DESIGN We investigated the frequency of establishing a diagnosis of a simple ulcerative cervicitis by histology in a cohort of 58 females with cervical cytology suggestive of intraepithelial neoplasia. RESULTS There was found a detection rate of 81.58% in the determination of ulcerative cervicitis by cytology and a rate of 100% in the determination of HPV-infection, CIN1, CIN2 and CIN3 respectively. There was no statistically significant difference between cytology and histology in the diagnosis of ultracerative cervicitis (p>0.5, chi-square). CONCLUSIONS There is an overestimation of the cytological signs in the diagnosis of ulcerative cervicitis 18.42%). There is also an excellent agreement in the diagnosis of HPV-infection and CIN grades (100%) between cytology and histology, discordant with the literature (2.4%-71%).
Nuchal translucency in dichorionic twins conceived after assisted reproduction

As opposed to biochemical markers of Down syndrome, nuchal translucency (NT) was once thought to be a more reliable screening marker for high order multiple pregnancies and pregnancies conceived after assisted conception. Recent data suggested that NT in singleton fetuses from assisted reproduction technology (ART) was thicker than those from singleton pregnancies. The present study compared the thickness of NT in dichorionic twins from natural conception and assisted reproduction.
HsCRP levels: Measurement of airway inflammation in asthmatic children

Background: The inflammatory marker, high‐sensitivity C‐reactive protein (HsCRP), is known to be related to non‐allergic asthma, obesity, cardiovascular disease and smoking in adults. The aim of the present study was to determine whether HsCRP is related to respiratory symptoms and pulmonary function test findings in asthmatic children.
A Novel Relay Method for Determining Low-Clearance Values

A novel relay method has been developed using cryopreserved human hepatocytes to measure intrinsic clearance of low-clearance compounds. The relay method involved transferring the supernatant from hepatocyte incubations to freshly thawed hepatocytes at the end of the 4-h incubation to prolong the exposure time to active enzymes in hepatocytes. An accumulative incubation time of 20 h or longer in hepatoctyes can be achieved using the method. The relay method was validated using seven commercial drugs (diazepam, disopyramide, theophylline, timolol, tolbutamide, S-warfarin, and zolmitriptan) that were metabolized by various cytochrome P450s with low human in vivo intrinsic clearance at approximately 2 to 15 ml · min−1 · kg−1. The results showed that the relay method produced excellent predictions of human in vivo clearance. The difference between in vitro and in vivo intrinsic clearance was within 2-fold for most compounds, which is similar to the standard prediction accuracy for moderate to high clearance compounds using hepatocytes. The relay method is a straightforward, relatively low cost, and easy-to-use new tool to address the challenges of low clearance in drug discovery and development.
Efficient Multi-secret Sharing Scheme Using Room Square

In 1979, secret sharing scheme was first proposed by Shamir. In a secret sharing scheme, each participant receives a secret share in such a way that only authorized subsets can reconstruct the secret. Compare with Shamir’s scheme, Juan and Huang proposed an efficient secret sharing scheme from room square in 2005. Their scheme gave a practical algorithm to reduce the computation complexity by using room square, and obtained as (n − 1, n)-threshold secret sharing scheme. However, there is not any (t, n)-threshold secret sharing scheme for t ≤ n − 2 with more efficient than Shamir’s scheme has been proposed. For this reason, this paper utilizes the characteristic of cycle to design four (t, n)-threshold secret sharing schemes for t = n − 2. These proposed schemes are not only more efficient than previous related works in the computational complexity, but also with the information rate is approximated optimal value 1. In addition, we combine the proposed scheme and the property of room square to present a new multi-secret sharing scheme in this paper.
Time-dependent Neural Processing of Auditory Feedback during Voice Pitch Error Detection

The neural responses to sensory consequences of a self-produced motor act are suppressed compared with those in response to a similar but externally generated stimulus. Previous studies in the somatosensory and auditory systems have shown that the motor-induced suppression of the sensory mechanisms is sensitive to delays between the motor act and the onset of the stimulus. The present study investigated time-dependent neural processing of auditory feedback in response to self-produced vocalizations. ERPs were recorded in response to normal and pitch-shifted voice auditory feedback during active vocalization and passive listening to the playback of the same vocalizations. The pitch-shifted stimulus was delivered to the subjects' auditory feedback after a randomly chosen time delay between the vocal onset and the stimulus presentation. Results showed that the neural responses to delayed feedback perturbations were significantly larger than those in response to the pitch-shifted stimulus occurring at vocal onset. Active vocalization was shown to enhance neural responsiveness to feedback alterations only for nonzero delays compared with passive listening to the playback. These findings indicated that the neural mechanisms of auditory feedback processing are sensitive to timing between the vocal motor commands and the incoming auditory feedback. Time-dependent neural processing of auditory feedback may be an important feature of the audio-vocal integration system that helps to improve the feedback-based monitoring and control of voice structure through vocal error detection and correction.
The maximum oxygen intake. An international reference standard of cardiorespiratory fitness.

Lack of cardiorespiratory fitness may well contribute to the increasing prevalence of degenerative cardiovascular disease throughout the world. As a first step towards co-ordinated and internationally comparable investigation of this problem, methods of measuring the reference standard of cardiorespiratory fitness-the maximum oxygen intake, (Vo(2))(max)-were compared by an international working party that met in Toronto in the summer of 1967.Repeated testing of 24 subjects showed that the (Vo(2))(max) was greatest on the treadmill, 3.4% smaller in a stepping test, and 6.6% smaller during use of a bicycle ergometer. There were also parallel differences in cardiac stroke volume. Uphill treadmill running was recommended for the laboratory measurement of (Vo(2))(max), and stepping or bicycle exercise for field studies. A discontinuous series of maximum tests caused some improvement in the fitness of subjects, and a "continuous" test (with small increases in load at 2-min intervals) was preferred.
Electromagnetic Design of Calibration Targets for MetOp-SG Microwave Instruments

We describe the electromagnetic development of microwave calibration units for the second generation of meteorological operational satellites. In particular, we focus on the electromagnetic and thermal design of on-board calibration targets (OBCT) for the microwave sounder (MWS) and the ice cloud imager (ICI), respectively. The OBCTs act as temperature reference for calibration. Therefore, they are required to exhibit a low electromagnetic reflectivity and a uniform temperature. This paper discusses the numerical design of pyramid absorbers for MWS and ICI. Based on theoretical studies, we have developed a novel pyramid design, which exhibits superior electromagnetic and thermal properties compared with conventionally used layouts. A comprehensive numerical study on the impact of common types of manufacturing tolerances has been carried out, and the most critical types were identified. This work presents remedies that reduce the susceptibility to manufacturing tolerances. All numerical results have been verified experimentally, and the manufactured OBCT prototypes have been shown to fulfill the specific requirements in all frequency bands.
Disposition kinetics of doxycycline in chickens naturally infected with Mycoplasma gallisepticum

1. The pharmacokinetic properties of doxycycline were determined in healthy chickens and chickens naturally infected with Mycoplasma gallisepticum after a single intravenous (i.v.) and oral administration of the drug at 20 mg/kg body weight. Tissue residues of the tested drug after an oral dose of 20 mg/kg given twice daily for 5 consecutive days were also estimated in diseased chickens. 2. The plasma concentrations of doxycycline following single i.v. and oral administration were higher in healthy chickens than in diseased ones. Following i.v. injection, the elimination half-life (t 1/2β), distribution half-life and mean residence time (MRT) were longer in healthy chickens than in diseased birds. The values of total body clearance (Cl B) and volume of distribution (V dss) were larger in healthy chickens than in diseased birds. 3. After single oral administration, the absorption half-life (t 1/2ab) and the elimination half-life were longer in normal birds than in diseased ones. The maximum plasma concentration of the drug was higher in normal chickens than in diseased ones. 4. Following repeated oral administration, the concentration of doxycycline in all tissues except muscle was higher than the corresponding concentrations in plasma. Concentrations of doxycycline in different tissues were in the following order: kidney > liver > lung > muscle. The drug was detected in liver and kidney in substantial concentrations on d 5 post administration of the last dose whereas, on d 7, its concentration in all tissues was below the lower limit of the sensitivity of the assay method used. Because of the low sensitivity of the microbiological assay method used in this study, a safe withdrawal time for doxycycline in diseased birds could not be estimated for the meanwhile.
The development and evaluation of a brief risk screening instrument for the psychiatric inpatient setting.

This paper reports on the development and evaluation of a risk screening instrument (RSI) intended for use by nursing staff on general acute psychiatric admission wards. The RSI comprised six questions concerning patient status on admission (e.g. sex, legal status, employment) and 11 items of judgement concerning the presentation of the patient (e.g. threatening behaviour, suicidality, family and social support). The interrater reliability of the RSI was calculated to be 85% overall. The predictive value of the RSI was not confirmed when tested against harmful incidents subsequent to admission. However, the mean RSI score of that group of patients involved in harmful incidents tended to be higher than that group of patients not involved in such incidents, and all such incidents were found to occur within eight days of admission. Analysis of other data collected in the course of the study revealed discrete patient groups and provided systematic insights into their characteristics, which are potentially valuable when considering the nursing skills required on acute psychiatric inpatient units. It is concluded that the RSI tested has the potential to contribute to the assessment and management of risk within the acute psychiatric inpatient setting, by augmenting and guiding clinical judgement.
Assessing inhibitory control in early‐stage Alzheimer's and Parkinson's disease using the Hayling Sentence Completion Test

The ability to inhibit irrelevant information is essential for coping with the demands of everyday life. Inhibitory deficits are present in all stages of dementia and commonly observed in people with Parkinson's disease (PwPD). Inhibition is frequently tested with the Stroop test, but this may lack ecological validity. This study investigates inhibitory control in people with Alzheimer's disease dementia (PwD) and PwPD using the Hayling Sentence Completion Test (HSCT), which aspires to be a more ecologically valid task. A total of 117 people completed the HSCT, a test where participants have to complete a sentence with an unrelated word. The sample comprised 30 PwD, 33 PwPD, and 54 healthy older controls. We compared response times and the number and type of errors across the three groups. Completion time in Part B (Inhibition) did not distinguish between PwD, PwPD, and controls when controlling for the initiation speed, but a higher proportion of Category A errors (producing a word that fits the sentence when instructed otherwise) was a unique characteristic of inferior performance in PwD and PwPD. While not part of the standard test scoring protocol, controlling for the initiation speed and distinguishing between speed and accuracy in test performance appear to be essential for accurate evaluation of the inhibitory control in HSCT in older people. The findings suggest that the HSCT may be sensitive to verbal suppression deficits and may provide insight into inhibitory control in PwD and PwPD.
Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma.

AIM To identify gene variants responsible for anthracycline-induced cardiotoxicity. PATIENTS & METHODS Polymorphisms of the NADPH oxidase subunits and of the anthracycline transporters ABCC1, ABCC2 and SLC28A3 were genotyped in elderly patients (61-80 years) treated for aggressive CD20(+) B-cell lymphomas with CHOP-14 with or without rituximab and followed up for 3 years. RESULTS The accumulation of RAC2 subunit genotypes TA/AA among cases was statistically significant upon adjustment for gender, age and doxorubicin dose in a multivariate logistic regression analysis (OR: 2.3, p = 0.028; univariate: OR: 1.8, p = 0.077). RAC2 and CYBA genotypes were significantly associated with anthracycline-induced cardiotoxicity in a meta-analysis of this and a similar previous study. CONCLUSION Our results support the theory that NADPH oxidase is involved in anthracycline-induced cardiotoxicity. Original submitted 9 July 2014; Revision submitted 19 December 2014.
Sensemaking and emotion in organizations

Emotion is a critical but relatively unexplored dimension of sensemaking in organizations. Existing models of sensemaking tend to ignore the role of emotion or portray it as an impediment. To address this problem, we explore the role that felt emotion plays in three stages of individual sensemaking in organizations. First, we examine emotion’s role in mediating the relationship between unexpected events and the onset of sensemaking processes. We argue that emotion signals the need for and provides the energy that fuels sensemaking, and that different kinds of emotions are more and less likely to play these roles. Second, we explore the role of emotion in shaping sensemaking processes, focusing on how emotions make sensemaking a more solitary or more interpersonal process, and a more generative or more integrative process. Third, we argue that sensemakers’ felt emotion plays an important role in concluding sensemaking, particularly through its effect on the plausibility of sensemaking accounts.
Enhancement of head and neck squamous cell carcinoma proliferation, invasion, and metastasis by tumor‐associated fibroblasts in preclinical models

Head and neck squamous cell carcinoma (HNSCC) has had little improvement in mortality rates in decades. A clearer understanding of the HNSCC tumor microenvironment will aid in finding more effective targeted therapies for this disease. Tumor‐associated fibroblasts (TAFs) are the largest stromal cellular components of the tumor microenvironment in HNSCC.
Arabidopsis LON 2 Is Necessary for Peroxisomal Function and Sustained Matrix Protein Import 1 [ C ] [ W ] [ OA ]

Relatively little is known about the small subset of peroxisomal proteins with predicted protease activity. Here, we report that the peroxisomal LON2 (At5g47040) protease facilitates matrix protein import into Arabidopsis (Arabidopsis thaliana) peroxisomes. We identified T-DNA insertion alleles disrupted in five of the nine confirmed or predicted peroxisomal proteases and found only two—lon2 and deg15, a mutant defective in the previously described PTS2-processing protease (DEG15/ At1g28320)—with phenotypes suggestive of peroxisome metabolism defects. Both lon2 and deg15 mutants were mildly resistant to the inhibitory effects of indole-3-butyric acid (IBA) on root elongation, but only lon2 mutants were resistant to the stimulatory effects of IBA on lateral root production or displayed Suc dependence during seedling growth. lon2 mutants displayed defects in removing the type 2 peroxisome targeting signal (PTS2) from peroxisomal malate dehydrogenase and reduced accumulation of 3-ketoacyl-CoA thiolase, another PTS2-containing protein; both defects were not apparent upon germination but appeared in 5to 8-d-old seedlings. In lon2 cotyledon cells, matrix proteins were localized to peroxisomes in 4-d-old seedlings but mislocalized to the cytosol in 8-d-old seedlings. Moreover, a PTS2-GFP reporter sorted to peroxisomes in lon2 root tip cells but was largely cytosolic in more mature root cells. Our results indicate that LON2 is needed for sustained matrix protein import into peroxisomes. The delayed onset of matrix protein sorting defects may account for the relatively weak Suc dependence following germination, moderate IBA-resistant primary root elongation, and severe defects in IBAinduced lateral root formation observed in lon2 mutants.
Contextual encoding in uniform and adaptive mesh-based lossless compression of MR images

We propose and evaluate a number of novel improvements to the mesh-based coding scheme for 3-D brain magnetic resonance images. This includes: 1) elimination of the clinically irrelevant background leading to meshing of only the brain part of the image; 2) content-based (adaptive) mesh generation using spatial edges and optical flow between two consecutive slices; 3) a simple solution for the aperture problem at the edges, where an accurate estimation of motion vectors is not possible; and 4) context-based entropy coding of the residues after motion compensation using affine transformations. We address only lossless coding of the images, and compare the performance of uniform and adaptive mesh-based schemes. The bit rates achieved (about 2 bits per voxel) by these schemes are comparable to those of the state-of-the-art three-dimensional (3-D) wavelet-based schemes. The mesh-based schemes have been shown to be effective for the compression of 3-D brain computed tomography data also. Adaptive mesh-based schemes perform marginally better than the uniform mesh-based methods, at the expense of increased complexity.