Miracle-dz/UniFAR-FTUs huggingface dataset:
Transmission control for heterogeneous network composed of MANET and terrestrial-satellite network

The satellite network has the advantages of wide coverage, convenient access, and the influence of the natural environment. Wireless multi-hop network is suitable for the occasion that cannot be easily or inconvenient to lay network facilities and the occasion of the need for rapid automatic networking. Multi-hop network and the satellite network may combine a heterogeneous network that can provide an effective and convenient way to access the network in the ocean or in remote areas. This paper, firstly, builds a heterogeneous network with satellite network and multi-hop network, and discusses the bandwidth delay product (BDP) of heterogeneous network, then proposes a new end-to-end congestion control algorithm. The proposed scheme at the outset increases the dynamic time interval for the initial transmission data that can reduce the backlog of burst data at the access point, and then increases the amount of data transmission in the slow start that can improve high bandwidth delay product of satellite network. In the congestion avoidance, it adjusts the congestion window size by monitoring the random packet loss and congestion packet loss. This algorithm can effectively solve the long delay in heterogeneous networks, and improve the accuracy of the high packet loss rate monitoring in multi hop networks and satellite networks. The proposed algorithm can effectively solve the influence of the long delay in the heterogeneous network, at the same time it can distinguish the different packet loss.
Rhamnose-Inducible Gene Expression in Listeria monocytogenes

Acid production from rhamnose is a characteristic phenotype of Listeria monocytogenes. We report the identification of the rhamnose transport and utilization operon located at lmo2846 to lmo2851, including the rhamnose-dependent promoter Prha. Expression of reporter genes under control of Prha on a single copy integration vector demonstrated its suitability for inducible gene expression in L. monocytogenes. Transcription initiation from Prha is dose dependent, and a concentration as low as 100 µM rhamnose was found sufficient for induction. Moreover, Prha is subject to glucose catabolite repression, which provides additional options for strict control of expression. Infection of human THP1 macrophages revealed that Prha is repressed in intracellular L. monocytogenes, which is explained by the absence of rhamnose in the cytosol and possible interference by catabolite repression. The Prha promoter provides a novel and useful tool for triggering gene expression in extracellular L. monocytogenes, whereas intracellular conditions prevent transcription from this promoter.
Meat and Fish Consumption and Cancer in Canada

In this study, we examined the association between meat and fish intake and the risk of various cancers. Mailed questionnaires were completed by 19,732 incident, histologically confirmed cases of cancer of the stomach, colon, rectum, pancreas, lung, breast, ovary, prostate, testis, kidney, bladder, brain, non-Hodgkin's lymphomas (NHL), and leukemia and 5,039 population controls between 1994 and 1997 in 8 Canadian provinces. Measurement included information on socioeconomic status, lifestyle habits, and diet. A 69-item food frequency questionnaire provided data on eating habits 2 yr before data collection. Odds ratios and 95% confidence intervals were derived through unconditional logistic regression. Total meat and processed meat were directly related to the risk of stomach, colon, rectum, pancreas, lung, breast (mainly postmenopausal), prostate, testis, kidney, bladder, and leukemia. Red meat was significantly associated with colon, lung (mainly in men), and bladder cancer. No relation was observed for cancer of the ovary, brain, and NHL. No consistent excess risk emerged for fish and poultry, which were inversely related to the risk of a number of cancer sites. These findings add further evidence that meat, specifically red and processed meat, plays an unfavorable role in the risk of several cancers. Fish and poultry appear to be favorable diet indicators.
Nurses’ Knowledge toward Hepatitis B and Hepatitis C in Guilan, Iran

Background: Health care workers (HCWs) represent high risk population for viral hepatitis infection. Objectives: This study sought to assess the knowledge of HCWs regarding hepatitis B (HBV) and hepatitis C (HCV) infection. Methods: In a multi-center cross sectional study, all HCWs from eight teaching hospitals were invited to participate in the study and to fill in a self-administered questionnaire. Results: A total of 1008 eligible HCWs have responded to the study. A high proportion of the study participants (55.4% and 52.9%) had unsatisfactory knowledge about HBV and HCV. Mean knowledge score toward HBV was significantly higher among more educated staff, p <0.001 and vaccinated personnel, P=0.02. Majority of responders answered correctly to transmission questions toward HBV and HCV (90% and 80%, respectively). There was statistically significant difference in only transmission domain score between various hospitals (p<0.05). The highest scores were related to surgical hospital. Conclusion: Although more than ninety percent of our participants were educated about HBV and HCV, knowledge about nature of disease, prevention, treatment and vaccine availability was unsatisfactory. Continuous training program toward viral infection is a matter of necessity.
Vascular Endothelial Growth Factor Regulates Reendothelialization and Neointima Formation in a Mouse Model of Arterial Injury

Background—The rate of reendothelialization is critical in neointima formation after arterial injury. Vascular endothelial growth factor (VEGF), a potent endothelial mitogen, has been advocated for accelerating endothelial repair and preventing intimal hyperplasia after percutaneous coronary interventions. However, the precise mechanism of action of VEGF treatment and the physiologic role of endogenous VEGF after arterial injury are not well described. To better understand the role of VEGF in arterial repair, we overexpressed both VEGF and a soluble, chimeric VEGF receptor (VEGF-trap), which binds free VEGF with high affinity, in a mouse model of arterial injury. Methods and Results—Four groups of C57BL/6 mice underwent denuding endothelial injury 1 day after systemic injection of recombinant adenovirus expressing (1) VEGF, (2) VEGF-trap, (3) VEGF plus VEGF-trap, or (4) control adenovirus. Circulating levels of adenovirus-encoded proteins were significantly elevated after gene transfer. VEGF overexpression accelerated reendothelialization and increased luminal endothelial cell proliferation 2 weeks after arterial injury (P<0.05), resulting in decreased neointima formation at 4 weeks compared with control (P<0.01). Cotreatment with VEGF-trap completely sequestered free VEGF and abrogated the beneficial effect of VEGF overexpression. Interestingly, sequestration of endogenous VEGF by VEGF-trap overexpression alone also led to delayed reendothelialization at 2 weeks (P<0.01) and increased neointima formation at 4 weeks (P<0.01). Conclusions—VEGF overexpression accelerated endothelial repair and inhibited neointima formation after arterial injury. Conversely, sequestration of exogenous and/or endogenous VEGF by VEGF-trap delayed reendothelialization and significantly increased neointima size. This demonstrates the therapeutic potential of VEGF but also emphasizes the important physiologic role of endogenous VEGF in vascular repair.
CHEMICAL REACTIONS AS Γ-LIMIT OF DIFFUSION

We study the limit of high activation energy of a special Fokker–Planck equation known as the Kramers–Smoluchowski equation (KS). This equation governs the time evolution of the probability density of a particle performing a Brownian motion under the influence of a chemical potential H/ε. We choose H having two wells corresponding to two chemical states A and B. We prove that after a suitable rescaling the solution to KS converges, in the limit of high activation energy (ε → 0), to the solution of a simpler system modeling the spatial diffusion of A and B combined with the reaction A B. With this result we give a rigorous proof of Kramers’s formal derivation, and we show how chemical reactions and diffusion processes can be embedded in a common framework. This allows one to derive a chemical reaction as a singular limit of a diffusion process, thus establishing a connection between two worlds often regarded as separate. The proof rests on two main ingredients. One is the formulation of the two disparate equations as evolution equations for measures. The second is a variational formulation of both equations that allows us to use the tools of variational calculus and specifically Γ-convergence.
Measurement of Spin-Orbit Alignment in an Extrasolar Planetary System

We determine the stellar, planetary, and orbital properties of the transiting planetary system HD 209458 through a joint analysis of high-precision radial velocities, photometry, and timing of the secondary eclipse. Of primary interest is the strong detection of the Rossiter-McLaughlin effect, the alteration of photospheric line profiles that occurs because the planet occults part of the rotating surface of the star. We develop a new technique for modeling this effect and use it to determine the inclination of the planetary orbit relative to the apparent stellar equator (λ = -4.°4 ± 1.°4), and the line-of-sight rotation speed of the star (v sin I⋆ = 4.70 ± 0.16 km s-1). The uncertainty in these quantities has been reduced by an order of magnitude relative to the pioneering measurements by Queloz and collaborators. The small but nonzero misalignment is probably a relic of the planet formation epoch, because the expected timescale for tidal coplanarization is larger than the age of the star. Our determination of v sin I⋆ is a rare case in which rotational line broadening has been isolated from other broadening mechanisms.
Serum Lipid Levels in Normal Persons: Findings of a Cooperative Study of Lipoproteins and Atherosclerosis

Measurements of Sf 12-20, Sf 20-100, and total serum cholesterol made on 10,690 men and 3,404 women are reported and the relation of lipid level to race, source, age, sex, blood pressure, and weight is described. Distributions for men 40 to 59 are reported in detail. The groups studied, while not selected as representative of the population at large, were remarkably similar in their lipid levels. The lipid levels of only 2 of the 33 groups—Los Angeles and the prisoners—differed significantly from the average. No convincing explanation for either of these exceptions was discovered. The data in this study were mainly from a white population. Data for nonwhites came primarily from 2 aberrant groups and were too meager to allow a clear characterization of lipid levels. The levels for nonwhites from these 2 sources were closer to those of the white members of these groups than to the levels of the general population. Cholesterol levels for men and women were found to be about the same at age 20. For both sexes the level rises with age but at first the rise is much greater for men than women. Above age 50, however, the level is higher for women than men and the level for women continues to rise after that age—at least within the age series for this study. The level for men reaches a peak at age 55, after which it declines. The relation of age and sex with lipid level for Sf 12-20 and Sf 20-100 appeared to be similar to that for cholesterol. Correlations of lipid levels with blood pressure and weight were positive but very low. Hypertension or obesity, however, is associated with some elevation of lipid levels. Sf 20-100 was found to be the most sensitive of the 3 lipid measures to sex and race differences. In the age group 40 to 59 it was the only one that exhibited a definite race and sex differential. In addition, it had the highest correlation with weight and with blood pressure.
Pointing the Unknown Words

The problem of rare and unknown words is an important issue that can potentially influence the performance of many NLP systems, including both the traditional count-based and the deep learning models. We propose a novel way to deal with the rare and unseen words for the neural network models using attention. Our model uses two softmax layers in order to predict the next word in conditional language models: one predicts the location of a word in the source sentence, and the other predicts a word in the shortlist vocabulary. At each time-step, the decision of which softmax layer to use choose adaptively made by an MLP which is conditioned on the context. ~We motivate our work from a psychological evidence that humans naturally have a tendency to point towards objects in the context or the environment when the name of an object is not known. ~We observe improvements on two tasks, neural machine translation on the Europarl English to French parallel corpora and text summarization on the Gigaword dataset using our proposed model.
Seizure‐associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy

This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, −30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 ± 0.7 years. The hippocampal volume loss was correlated to the number of generalized seizures between the scans (p = 0.0007, r = 0.6), suggesting seizure‐associated hippocampal damage.
OASIS: Anycast for Any Service

Global anycast, an important building block for many distributed services, faces several challenging requirements. First, anycast response must be fast and accurate. Second, the anycast system must minimize probing to reduce the risk of abuse complaints. Third, the system must scale to many services and provide high availability. Finally, and most importantly, such a system must integrate seamlessly with unmodified client applications. In short, when a new client makes an anycast query for a service, the anycast system must ideally return an accurate reply without performing any probing at all. This paper presents OASIS, a distributed anycast system that addresses these challenges. Since OASIS is shared across many application services, it amortizes deployment and network measurement costs; yet to facilitate sharing, OASIS has to maintain network locality information in an application-independent way. OASIS achieves these goals by mapping different portions of the Internet in advance (based on IP prefixes) to the geographic coordinates of the nearest known landmark. Measurements from a preliminary deployment show that OASIS, surprisingly, provides a significant improvement in the performance that clients experience over state-of-the-art on-demand probing and coordinate systems, while incurring much less network overhead.
Spatiotemporal expression of PSD‐95 in Fmr1 knockout mice brain

To investigate and compare the spatial and temporal expression of post‐synaptic density‐95 (PSD‐95) in Fmr1 knockout mice (the animal model of fragile X syndrome, FXS) and wild‐type mice brain, on postnatal day 7 (P7), P14, P21, P28 and P90, mice from each group were decapitated, and three principal brain regions (cerebral cortex, hippocampus and cerebellum) were obtained and stored for later experiments. PSD‐95 mRNA in the three brain areas was analyzed with quantitative RT‐PCR. PSD‐95 protein was measured by immunohistochemical staining and Western blot. In the three principal brain areas of Fmr1 knockout mice and wild‐type mice, the expression of PSD‐95 mRNA and protein were detected at the lowest levels on P7, and then significantly increased on P14, reaching the peak levels in adolescents or adults. Moreover, it was found that PSD‐95 mRNA and protein in the hippocampus were significantly decreased in Fmr1 knockout mice during the developmental period (P7, P14, P21 and P28) as well as at adulthood (P90) (P < 0.05, and P < 0.01, respectively). However, there was no significant difference of expression of PSD‐95 in the cortex and cerebellum between Fmr1 knockout and wild mice. The expression of PSD‐95 in the hippocampus might be regulated by fragile X mental retardation protein (FMRP) during mice early developmental and adult periods. It is suggested that impairment of PSD‐95 is possibly involved in hippocampal‐dependent learning defects, which are common in people with FXS.
Dracunculiasis, Onchocerciasis, Schistosomiasis, and Trachoma

The four diseases discussed in this chapter (dracunculiasis, onchocerciasis, schistosomiasis, and trachoma) are among the officially designated “Neglected Tropical Diseases,” and each is also both the result of and a contributor to the poverty of many rural populations. To various degrees, they all have adverse effects on health, agricultural productivity, and education. The Carter Center decided to work on these health problems because of their adverse effect on the lives of poor people and the opportunity to help implement effective interventions. As a result of the global campaign spearheaded by the Carter Center since 1986, the extent of dracunculiasis has been reduced from 20 to five endemic countries and the number of cases reduced by more than 99%. We have helped administer nearly 20% of the 530 million Mectizan (ivermectin) doses for onchocerciasis, which is now being controlled throughout most of Africa, and is progressing toward elimination in the Americas. Since 1999, two Nigerian states have been using village‐based health workers originally recruited to work on onchocerciasis to also deliver mass treatment and health education for schistosomiasis and lymphatic filariasis. They now also distribute vitamin A supplements and bed nets to prevent malaria and lymphatic filariasis. Ethiopia aims to eliminate blinding trachoma in the Amhara Region of that highest‐endemicity country by 2012, already constructing more than 300,000 latrines and other complementary interventions. Because of the synergy between these diseases and poverty, controlling or eliminating the disease also reduces poverty and increases self‐reliance.
Trends in the use of intracytoplasmatic sperm injection marked variability between countries.

BACKGROUND ICSI is used increasingly often compared with standard IVF. The aim of the present study was to analyse the changes in the use of ICSI, and discuss possible causes and consequences. METHODS Data from National and Regional registers were analysed for trends in the use of ICSI and indications for assisted reproductive technology (ART). RESULTS The use of ICSI increased from 39.6% of ART cycles in 1997 to 58.9% in 2004 (USA 57.5%, Australia/New Zealand 58.6%, Europe 59.3%). The Nordic countries, the Netherlands and the UK used ICSI to a low extent (40.0-44.3%), whereas Austria, Belgium and Germany (68.5-72.9%) and the southern European countries like Greece, Italy and Spain used ICSI frequently (66.0-81.2%). The marked increase in the proportion of ICSI cycles seems primarily due to an increased use in couples classified as having mixed causes of infertility, unexplained infertility and advanced age together with a relative decline in tubal factor infertility. An absolute increase in the prevalence of couples with impairment in semen quality remains a possibility. CONCLUSIONS ICSI is used increasingly, but huge differences exist between countries within Europe. It is not possible to determine specific factors that explain the differences. As ICSI does not give higher pregnancy rates than IVF in couples without male factors, and as it adds additional costs, infertile couples and society may benefit from a less frequent use of ICSI in some countries.
On the Origins of Suboptimality in Human Probabilistic Inference

Humans have been shown to combine noisy sensory information with previous experience (priors), in qualitative and sometimes quantitative agreement with the statistically-optimal predictions of Bayesian integration. However, when the prior distribution becomes more complex than a simple Gaussian, such as skewed or bimodal, training takes much longer and performance appears suboptimal. It is unclear whether such suboptimality arises from an imprecise internal representation of the complex prior, or from additional constraints in performing probabilistic computations on complex distributions, even when accurately represented. Here we probe the sources of suboptimality in probabilistic inference using a novel estimation task in which subjects are exposed to an explicitly provided distribution, thereby removing the need to remember the prior. Subjects had to estimate the location of a target given a noisy cue and a visual representation of the prior probability density over locations, which changed on each trial. Different classes of priors were examined (Gaussian, unimodal, bimodal). Subjects' performance was in qualitative agreement with the predictions of Bayesian Decision Theory although generally suboptimal. The degree of suboptimality was modulated by statistical features of the priors but was largely independent of the class of the prior and level of noise in the cue, suggesting that suboptimality in dealing with complex statistical features, such as bimodality, may be due to a problem of acquiring the priors rather than computing with them. We performed a factorial model comparison across a large set of Bayesian observer models to identify additional sources of noise and suboptimality. Our analysis rejects several models of stochastic behavior, including probability matching and sample-averaging strategies. Instead we show that subjects' response variability was mainly driven by a combination of a noisy estimation of the parameters of the priors, and by variability in the decision process, which we represent as a noisy or stochastic posterior.
Alterations in White Matter Structure in Young Children With Type 1 Diabetes

OBJECTIVE To investigate whether type 1 diabetes affects white matter (WM) structure in a large sample of young children. RESEARCH DESIGN AND METHODS Children (ages 4 to <10 years) with type 1 diabetes (n = 127) and age-matched nondiabetic control subjects (n = 67) had diffusion weighted magnetic resonance imaging scans in this multisite neuroimaging study. Participants with type 1 diabetes were assessed for HbA1c history and lifetime adverse events, and glucose levels were monitored using a continuous glucose monitor (CGM) device and standardized measures of cognition. RESULTS Between-group analysis showed that children with type 1 diabetes had significantly reduced axial diffusivity (AD) in widespread brain regions compared with control subjects. Within the type 1 diabetes group, earlier onset of diabetes was associated with increased radial diffusivity (RD) and longer duration was associated with reduced AD, reduced RD, and increased fractional anisotropy (FA). In addition, HbA1c values were significantly negatively associated with FA values and were positively associated with RD values in widespread brain regions. Significant associations of AD, RD, and FA were found for CGM measures of hyperglycemia and glucose variability but not for hypoglycemia. Finally, we observed a significant association between WM structure and cognitive ability in children with type 1 diabetes but not in control subjects. CONCLUSIONS These results suggest vulnerability of the developing brain in young children to effects of type 1 diabetes associated with chronic hyperglycemia and glucose variability.