Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of 14,500 operated knees registered in the Danish Knee Ligament Reconstruction Register: registration completeness and validity of key variables

Introduction The aim of this study was to validate the registration in the Danish Knee Ligament Reconstruction Register (DKRR) by assessing the registration completeness of the anterior cruciate ligament (ACL) reconstruction code and detecting the validity of important key variables. Furthermore, we assessed data quality of patient-related outcome scores. Material and methods All operation codes for ACL reconstruction from 2005–2011 were identified in the Danish National Registry of Patients and were compared with the cases registered in the DKRR to compute the completeness of registration. We also assessed the validity of key variables in the DKRR using medical records as a reference standard to compute the positive predictive value. Finally, we assessed potential differences between responders and nonresponders to subjective patient-related outcome scores (Knee Injury and Osteoarthritis Outcome Score [KOOS] and Tegner scores) 1 year after surgery. Results The completeness of the registration of patients in the DKRR increased from 60% (2005) to 86% (2011). Large-volume hospitals had a higher completeness than small-volume hospitals. With a positive predictive value between 85%–100%, the validity of key variables was good. KOOS scores versus Tegner scores for responders and nonresponders were comparable. Conclusion The results show a good registration of ACL reconstruction procedures in the DKRR, but there is room for improvement mainly at small-volume hospitals. Overall, the validity of the key variables in the DKRR was good and no difference was found in KOOS and Tegner scores for responders versus nonresponders. Therefore, we conclude that the DKRR is a valid source for future research.
The K-Band Luminosity Function in Galaxy Clusters to z

We present K-band luminosity functions for galaxies in a heterogeneous sample of 38 clusters at 0.1 < z < 1. Using infrared-selected galaxy samples, which generally reach 2 mag fainter than the characteristic galaxy luminosity L*, we fitted Schechter functions to background-corrected cluster galaxy counts to determine K* as a function of redshift. Because of the magnitude limit of our data, the faint-end slope α is fixed at -0.9 in the fitting process. We find that K*(z) departs from no-evolution predictions at z > 0.4 and is consistent with the behavior of a simple, passive luminosity evolution model in whichgalaxies form all their stars in a single burst at zf = 2(3) in an H0 = 65 km s-1 Mpc-1, ΩM = 0.3, ΩΛ = 0.7(0) universe. This differs from the flat or negative infrared luminosity evolution, which has been reported for high-redshift field galaxy samples. We find that the observed evolution appears to be insensitive to cluster X-ray luminosity or optical richness, implying little variation in the evolutionary history of galaxies over the range of environmental densities spanned by our cluster sample. These results support and extend previous analyses based on the color evolution of high-redshift cluster E/S0 galaxies, indicating not only that their stellar populations formed at high-redshift, but that the assembly of the galaxies themselves was largely complete by z ≈ 1 and that subsequent evolution down to the present epoch was primarily passive.
FISCAL CONSOLIDATIONS AND THEIR EFFECTS ON INCOME

This paper investigates the effects of fiscal consolidations on income inequality. Although fiscal consolidations have become a popular policy instrument and research topic, their effects on income inequality are relatively unexplored. We thus econometrically analyse the evolution of Gini coefficients during and after austerity measures. The paper relies on panel data techniques using a sample of 17 high-income countries during the period of 1978 – 2009. We find that a consolidation (measured by a deliberate improvement of the primary budget balance) significantly increases income inequality. More specifically, an improvement of the primary budget balance by about one percent of GDP is associated with an increase in market income inequality of 0.6% and a smaller increase in net income inequality the following year. In addition, this paper explores the discretionary effect of different consolidation compositions. To do so, we differentiate between consolidations that are either exclusively undertaken through spending cuts, tax increases or a combination of both. Thereby, we show that tax-only consolidations tend to be equality-friendly but also rather small in size while the opposite is true for spending-only and mixed consolidations. These findings point to a more pronounced trade-off between different consolidation policy goals than is currently believed.
God and the Welfare State - Substitutes or Complements? An Experimental Test of the Effect of Belief in God's Control

Belief in God’s control of the world is common to many of the world’s religions, but there are conflicting predictions regarding its role in shaping attitudes toward the welfare state. While the devout are expected to support pro-social values like helping others, and thus might be supportive of the welfare state, the possibility of taking action is undermined by the belief in God’s absolute control over world affairs and in a morally perfect providence, who is responsible for the fates of individuals. As the literature provides mixed results on this question, this study examines the role of belief in God’s control on welfare attitudes using three priming experiments and two priming tasks, carried out with a design that is both cross-cultural (US vs. Israel) and cross-religious tradition (Judaism vs. Catholicism). We find evidence that, largely, belief in God’s control increases support for income redistribution among Israeli Jews (study 1), American Jews (study 2), and American Catholics (study 3). The findings suggest that the traditional and common political gap between the economic left and the religious, based on the evaluation that religious beliefs lead to conservative economic preferences, may be overstated.
How Hard Can It Be? Designing and Implementing a Deployable Multipath TCP

Networks have become multipath: mobile devices have multiple radio interfaces, datacenters have redundant paths andmultihoming is the normfor big server farms. Meanwhile, TCP is still only single-path. Is it possible to extend TCP to enable it to support multiple paths for current applications on today's Internet? The answer is positive. We carefully review the constraints--partly due to various types of middleboxes-- that influenced the design of Multipath TCP and show how we handled them to achieve its deployability goals. We report our experience in implementing Multipath TCP in the Linux kernel and we evaluate its performance. Our measurements focus on the algorithms needed to efficiently use paths with different characteristics, notably send and receive buffer tuning and segment reordering. We also compare the performance of our implementation with regular TCP on web servers. Finally, we discuss the lessons learned from designing MPTCP.
Role of content in solving the binding problem in working memory

A system for monitoring ambient carbon monoxide. Light from a source (14) is directed against a measuring element (10) which darkens in color as it absorbs carbon monoxide. The light reflected from the element is received by a photocell (16) which generates an electrical signal proportional to the intensity of the reflected light received thereby. The signal is sampled periodically, and stored in a microprocessor (24) which computes the rate of change of the signals. The periodic measurement of the intensity of the light can be varied in response to the rate of change of the light intensity measurement. When the rate of change reaches a level indicative of an unsafe level of ambient carbon monoxide, an alarm (34) is energized. Light from the source is simultaneously directed against a reference element (12) with the light reflected therefrom being received by a photocell (18) which generates an electrical signal proportional to the intensity of the light received thereby. A comparator (30) compares the electrical signal generated by the photocells and energizes an indicator (32) when the comparison indicates that the measuring element has absorbed sufficient carbon monoxide to require that the element be replaced.
Numerical Investigation of Case Hardening of Plant Tissue During Drying and Its Influence on the Cellular-Level Shrinkage

Dried plant food materials are one of the major contributors to the global food industry. Widening the fundamental understanding of different mechanisms of food material alterations during drying assists the development of novel dried food products and processing techniques. In this regard, case hardening is an important phenomenon, commonly observed during the drying processes of plant food materials, which significantly influences the product quality and process performance. In this work, a mesh-free-based 2D numerical model developed by the authors is further improved and used to simulate the influence of case hardening on shrinkage characteristics of plant tissues during drying. In order to model the fluid mechanisms of plant cells, smoothed particle hydrodynamics (SPH), which is a popular mesh-free technique used to solve hydrodynamics problems, is used. The cell wall mechanisms are modeled using the discrete element method (DEM). The model is fundamentally more capable of simulating large deformations of multiphase materials compared to conventional grid-based modeling techniques such as finite element methods (FEM) or finite difference methods (FDM). Case hardening is implemented by maintaining distinct moisture levels in the different cell layers of a given tissue. In order to compare and investigate different factors influencing tissue deformation under case hardening, four different plant tissue varieties (apple, potato, carrot, and grape) are studied. The simulation results indicate that the inner cells of any given tissue undergo limited shrinkage and cell wall wrinkling, compared to the case-hardened outer cell layers of the tissues. For a given dried tissue condition, the case-hardened cellular deformations are highly influenced by the unique characteristics of the different tissues, such as cell size, cell fluid turgor pressure, and cell wall properties.
Recent Developments in the Retail Prices Index

The first concerns the representativeness of the RPI, that is the extent to which the RPI is representative of the experience of a wide range of household types, and in particular low income households, bearing in mind the rapid inflation in recent years. The paper discusses the main technical principles involved, which of course are much concerned with the weighting pattern of the index. It also gives the results of some practical studies which shed light on the issue.
Adaptation of an empirical model for erythemal ultraviolet irradiance

In this work we adapt an empirical model to esti- mate ultraviolet erythemal irradiance (UVER) using experi- mental measurements carried out at seven stations in Spain during four years (2000-2003). The measurements were taken in the framework of the Spanish UVB radiometric net- work operated and maintained by the Spanish Meteorolog- ical Institute. The UVER observations are recorded as half hour average values. The model is valid for all-sky condi- tions, estimating UVER from the ozone columnar content and parameters usually registered in radiometric networks, such as global broadband hemispherical transmittance and optical air mass. One data set was used to develop the model and another independent set was used to validate it. The model provides satisfactory results, with low mean bias er- ror (MBE) for all stations. In fact, MBEs are less than 4% and root mean square errors (RMSE) are below 18% (except for one location). The model has also been evaluated to esti- mate the UV index. The percentage of cases with differences of 0 UVI units is in the range of 61.1% to 72.0%, while the percentage of cases with differences of ±1 UVI unit covers the range of 95.6% to 99.2%. This result confirms the ap- plicability of the model to estimate UVER irradiance and the UV index at those locations in the Iberian Peninsula where there are no UV radiation measurements.
P55 tumour necrosis factor receptor in bone marrow-derived cells promotes atherosclerosis development in low-density lipoprotein receptor knock-out mice.

AIMS Tumour necrosis factor (TNF) is a pivotal pro-inflammatory cytokine with a clear pathogenic role in many chronic inflammatory diseases, and p55 TNF receptor (TNFR) mediates the majority of TNF responses. The aim of the current study was to investigate the role of p55 TNFR expression in bone marrow-derived cells, in atherosclerotic lesion development. METHODS AND RESULTS Irradiated low-density lipoprotein receptor knock-out mice were reconstituted with either p55 TNFR knock-out or control haematopoietic stem cells to generate chimeras deficient or wild-type for p55 TNFR specifically in bone marrow-derived cells, including macrophages. Upon high fat feeding, p55 TNFR knock-out transplanted mice developed smaller atherosclerotic lesions. These lesions were characterized by the presence of smaller foam cells and a reduced macrophage foam cell area. They did not differ in other compositional characteristics as determined by quantification of inflammatory T-cell and neutrophil influx, apoptotic and necrotic cell death, and collagen content. In vitro studies confirmed a significant defect in modified lipoprotein endocytosis by p55 TNFR knock-out macrophages due to reduced scavenger receptor class A expression. Interestingly, plasma cytokine/chemokine profile analysis indicated that monocyte chemoattractant protein-1 (MCP-1) levels, a major chemokine involved in atherogenesis, were consistently and significantly lower in p55 TNFR knock-out transplanted mice compared with controls, before and after high fat feeding. CONCLUSION p55 TNFR expression in bone marrow-derived cells contributes to the development of atherosclerosis by enhancing lesional foam cell formation and by promoting the expression of pro-atherosclerotic chemokines such as MCP-1.
Consumer Credit Scoring Models with Limited Data

In this paper we design the neural network consumer credit scoring models for financial institutions where data usually used in previous research are not available. We use extensive primarily accounting data set on transactions and account balances of clients available in each financial institution. As many of these numerous variables are correlated and have very questionable information content, we considered the issue of variable selection and the selection of training and testing sub-sets crucial in developing efficient scoring models. We used a genetic algorithm for variable selection. In dividing performing and nonperforming loans into training and testing sub-sets we replicated the distribution on Kohonen artificial neural network, however, when evaluating the efficiency of models, we used k-fold cross-validation. We developed consumer credit scoring models with error back-propagation artificial neural networks and checked their efficiency against models developed with logistic regression. Considering the dataset of questionable information content, the results were surprisingly good and one of the error back-propagation artificial neural network models has shown the best results. We showed that our variable selection method is well suited for the addressed problem.
A Silencer-Proximal Intronic Region Is Required for Sustained CD4 Expression in Postselection Thymocytes

It has been proposed that differential kinetics of CD4/CD8 coreceptors regulate fate choice of selected thymocytes. Sustained signals by interaction between MHC class II and TCR/CD4 is required for commitment to the CD4 helper lineage. Although prematurely terminated MHC–TCR/CD4 interaction in transgenic mouse models results in lineage redirection, it is unclear whether CD4 expression is actively maintained by endogenous cis-elements to facilitate prolonged signaling under physiological conditions. In this article, we show that sustained CD4 expression in postselection thymocytes requires an intronic sequence containing an uncharacterized DNase I hypersensitivity (DHS) site located 3′ to the silencer. Despite normal CD4 expression before selection, thymocytes lacking a 1.5-kb sequence in intron 1 including the 0.4-kb silencer and the DHS, but not the 0.4-kb silencer alone, failed to maintain CD4 expression upon positive selection and are redirected to the CD8 lineage after MHC class II–restricted selection. Furthermore, CpG dinucleotides adjacent to the DHS are hypermethylated in CD8+ T cells. These results indicate that the 1.5-kb cis-element is required in postselection thymocytes for helper lineage commitment, presumably mediating the maintenance of CD4 expression, and suggest that inactivation of the cis-element by DNA methylation may contribute to epigenetic Cd4 silencing.
Dynamics of Industry and Innovation: Organizations, Networks and Systems What Determines Absorptive Capacity

The paper empirically analyses the effect of R&D activities, human resource and knowledge management, and the organisation of knowledge sharing within a firm on the absorptive capacity of innovative firms. Using data from the German innovation survey we investigate how firms are able to exploit knowledge from external partners for successful innovation activities. We distinguish between three types of absorptive capacity for three different types of knowledge, namely absorptive capacity to use knowledge from a firm's own industry, from other industries, and knowledge from research institutions. The estimation results show that the determinants of absorptive capacities differ with respect to the type of knowledge absorbed for innovation activities. In particular we find that the R&D intensity does not significantly influence absorptive capacity. Additionally, our results suggest that absorptive capacity is path-dependent and firms can influence their ability to exploit external knowledge by stimulating the involvement of individuals in innovation projects of a firm.
Cell type specificity and structural determinants of IRES activity from the 5′ leaders of different HIV-1 transcripts

Internal ribosome entry site (IRES) RNAs are important regulators of gene expression, but their diverse molecular mechanisms remain partially understood. The HIV-1 gag transcript leader contains an IRES that may be a good model for understanding the function of many other IRESs. We investigated the possibility that this IRES’ function is linked to both the structure of the RNA and its cellular environment. We find that in the context of a bicistronic reporter construct, HIV-1 gag IRES’ activity is cell type-specific, with higher activity in T-cell culture systems that model the natural target cells for HIV-1 infection. This finding underscores how an IRES may be fine tuned to function in certain cells, perhaps owing to cell type-specific protein factors. Using RNA probing and mutagenesis, we demonstrate that the HIV-1 gag IRES does not use pre-folded RNA structure to drive function, a finding that gives insight into how conformationally dynamic IRESs operate. Furthermore, we find that a common exon drives IRES activity in a diverse set of alternatively spliced transcripts. We propose a mechanism in which a structurally plastic RNA element confers the ability to initiate translation internally, and activity from this common element is modulated by 3′ nucleotides added by alternative splicing.
Effects of Asiatic Acid on Spatial Working Memory and Cell Proliferation in the Adult Rat Hippocampus

Asiatic acid is a pentacyclic triterpene from Centella asiatica. Previous studies have reported that asiatic acid exhibits antioxidant and neuroprotective activities in cell culture. It also prevents memory deficits in animal models. The objective of this study was to investigate the relationship between spatial working memory and changes in cell proliferation within the hippocampus after administration of asiatic acid to male Spraque-Dawley rats. Control rats received vehicle (propylene glycol) while treated rats received asiatic acid (30 mg/kg) orally for 14 or 28 days. Spatial memory was determined using the novel object location (NOL) test. In animals administered asiatic acid for both 14 and 28 days, the number of Ki-67 positive cells in the subgranular zone of the dentate gyrus was significantly higher than in control animals. This was associated with a significant increase in their ability to discriminate between novel and familiar object locations in a novel object discrimination task, a hippocampus-dependent spatial memory test. Administration of asiatic acid also significantly increased doublecortin (DCX) and Notch1 protein levels in the hippocampus. These findings demonstrate that asiatic acid treatment may be a potent cognitive enhancer which improves hippocampal-dependent spatial memory, likely by increasing hippocampal neurogenesis.
Heteroplasmy and Ancient Translocation of Mitochondrial DNA to the Nucleus in the Chinese Horseshoe Bat (Rhinolophus sinicus) Complex

The utility and reliability of mitochondrial DNA sequences in phylogenetic and phylogeographic studies may be compromised by widespread and undetected nuclear mitochondrial copies (numts) as well as heteroplasmy within individuals. Both numts and heteroplasmy are likely to be common across diverse taxa yet few studies have characterised their frequencies and variation at the intra-specific level. Here we report the presence of both numts and heteroplasmy in the mitochondrial control region of the Chinese horseshoe bat Rhinolophus sinicus. In total we generated 123 sequences from 18 bats, which contained two different numt clades (i.e. Numt-1 and Numt-2) and one mtDNA clade. The sequence divergence between Numt-1 and Numt-2 was 16.8% and each numt type was found in all four R. sinicus taxa, suggesting either two ancient translocations of mitochondrial DNA into the nucleus from the same source taxon, or a single translocation from different source taxa that occurred before the split of R. sinicus into different lineages. Within the mtDNA clade, phylogenetic relationships among the four taxa of R. sinicus were similar to those seen in previous results. Based on PCR comparisons, heteroplasmy was inferred between almost all individuals of R. sinicus with respect to sequence variation. Consistent with introgression of mtDNA between Central sinicus and septentrionalis, individuals from these two taxa exhibited similar signatures of repeated sequences in the control region. Our study highlights the importance of testing for the presence of numts and heteroplasmy when applying mtDNA markers to phylogenetic studies.