Miracle-dz/UniFAR-FTUs huggingface dataset:
Mortality and Recovery After Stroke in The Gambia

Background and Purpose— There are no previously published studies of the long-term outcome of stroke in sub-Saharan Africa. Our goal was to determine the case fatality, time to and cause of death, and recovery in a hospital cohort of stroke patients in The Gambia. Methods— For 1 year beginning April 1, 1990, any patient presenting to the Royal Victoria Hospital (Banjul) with a diagnosis of stroke or having a stroke as an inpatient was recruited. After a standardized assessment, patients were followed up at 1 month, 6 months, and 3 to 4 years to assess recovery or, for those who died, record the date and likely cause of death. Results— Mean age of the 106 patients (70 men) was 58 years (range, 20 to 93 years). By 1 and 6 months, 29 (27%) and 47 (44%), respectively, had died, with only 27 (25%) surviving to final follow-up (4 patients not traced). Death occurred in hospital in 43 patients (57%). Cause of death was the initial stroke in 46 (61%), further stroke in 5 (7%), infection in 9 (12%), miscellaneous in 8 (11%) (only 1 vascular), and unknown in 7 (9%). On Cox regression analysis, incontinence in the first 24 hours, sensory inattention, and impaired gag reflex on admission were significant predictors of mortality. Predictors of recovery were similar to those of developed countries. Conclusions— Despite the young mean age, there was a high case fatality rate. The main cause of death was the stroke itself, and ischemic heart disease was very rare.
In-Cell Self-Capacitive-Type Mobile Touch System and Embedded Readout Circuit in Display Driver IC

A mobile display system, which includes a self- capacitive type in-cell touch screen panel and a display driver IC, in which the readout circuit is embedded, is developed for reduced cost, improved display performance, and superior touch performance. A touch electrode is implemented with a segmented common electrode of an LCD display. The display system of the in-cell touch panel is 5.7-in a-Si HD (720 × 1280), the number of touch electrodes is 576 (18 × 32), and the sensor pitch is approximately 4 mm. Compared to the display-only system, display performance degradation does not occur in the proposed system since in-cell technology is adopted. Despite using a self-capacitance sensing method in the panel, unlimited multitouch is available by using an all-point sensing scheme; this system shows a touch accuracy of less than 0.2 mm and signal-to-noise ratio is measured to be more than 48 dB in the entire panel without any digital filter. To enhance the touch performance, we proposed noise reduction techniques that are strongly related to the display operation, such as base line compensation, delta adding correlated double sampling, and the use of a high-voltage charge compensator. The power consumption including micro controller unit (MCU) is less than 30 mW.
Retrospective comparison of the efficacy of fluconazole or itraconazole for the treatment of systemic blastomycosis in dogs.

BACKGROUND Itraconazole is recommended for treatment of blastomycosis in dogs. Some evidence suggests that fluconazole might be less hepatotoxic than itraconazole. OBJECTIVES To compare (1) incidence of clinical remission and death; (2) treatment duration; (3) total drug cost; (4) incidence of relapse; and (5) incidence of increased ALT activities in dogs with blastomycosis treated with fluconazole or itraconazole. ANIMALS One hundred and forty-four dogs with systemic blastomycosis treated with itraconazole or fluconazole from 1998 to 2008. METHODS Retrospective case review. Information obtained included signalment, body weight, clinical signs, drug regimen, treatment duration, time to clinical remission, and laboratory results. RESULTS Neither treatment efficacy between fluconazole (75% remission) and itraconazole (90% remission) nor relapse rate (18% for itraconazole, 22% for fluconazole) was significantly different (P = .13, .75, respectively). Treatment duration was significantly longer for fluconazole (median 183 days) than for itraconazole (138 days; P = .001). Costs for fluconazole (median $1,223) were significantly less than for itraconazole ($3,717; P < .001). Incidence of increased ALT activities was not significantly different between groups (17% [3/18] for fluconazole, 26% [6/23] for itraconazole; P = .71). CONCLUSIONS Fluconazole is associated with survival to clinical remission in 75% of dogs with blastomycosis. Although dogs receiving fluconazole were treated longer, drug costs were one-third those of itraconazole. Hepatotoxicosis, as estimated by increases in serum ALT activity, can be observed with similar incidence for both drugs.
Carbon Isotope Fractionation during Anaerobic Degradation of Methyl tert-Butyl Ether under Sulfate-Reducing and Methanogenic Conditions

ABSTRACT Methyl tert-butyl ether (MTBE), an octane enhancer and a fuel oxygenate in reformulated gasoline, has received increasing public attention after it was detected as a major contaminant of water resources. Although several techniques have been developed to remediate MTBE-contaminated sites, the fate of MTBE is mainly dependent upon natural degradation processes. Compound-specific stable isotope analysis has been proposed as a tool to distinguish the loss of MTBE due to biodegradation from other physical processes. Although MTBE is highly recalcitrant, anaerobic degradation has been demonstrated under different anoxic conditions and may be an important process. To accurately assess in situ MTBE degradation through carbon isotope analysis, carbon isotope fractionation during MTBE degradation by different cultures under different electron-accepting conditions needs to be investigated. In this study, carbon isotope fractionation during MTBE degradation under sulfate-reducing and methanogenic conditions was studied in anaerobic cultures enriched from two different sediments. Significant enrichment of 13C in residual MTBE during anaerobic biotransformation was observed under both sulfate-reducing and methanogenic conditions. The isotopic enrichment factors (ε) estimated for each enrichment were almost identical (−13.4 to −14.6; r2 = 0.89 to 0.99). A ε value of −14.4 ± 0.7 was obtained from regression analysis (r2 = 0.97, n = 55, 95% confidence interval), when all data from our MTBE-transforming anaerobic cultures were combined. The similar magnitude of carbon isotope fractionation in all enrichments regardless of culture or electron-accepting condition suggests that the terminal electron-accepting process may not significantly affect carbon isotope fractionation during anaerobic MTBE degradation.
Deep Learning for Algorithm Portfolios

It is well established that in many scenarios there is no single solver that will provide optimal performance across a wide range of problem instances. Taking advantage of this observation, research into algorithm selection is designed to help identify the best approach for each problem at hand. This segregation is usually based on carefully constructed features, designed to quickly present the overall structure of the instance as a constant size numeric vector. Based on these features, a plethora of machine learning techniques can be utilized to predict the appropriate solver to execute, leading to significant improvements over relying solely on any one solver. However, being manually constructed, the creation of good features is an arduous task requiring a great deal of knowledge of the problem domain of interest. To alleviate this costly yet crucial step, this paper presents an automated methodology for producing an informative set of features utilizing a deep neural network. We show that the presented approach completely automates the algorithm selection pipeline and is able to achieve significantly better performance than a single best solver across multiple problem domains.
Band-pass response properties of rat SI neurons.

Rats typically employ 4- to 12-Hz "whisking" movements of their vibrissae during tactile exploration. The intentional sampling of signals in this frequency range suggests that neural processing of tactile information may be differentially engaged in this bandwidth. We examined action potential responses in rat primary somatosensory cortex (SI) to a range of frequencies of vibrissa motion. Single vibrissae were mechanically deflected with 5-s pulse trains at rates </=40 Hz. As previously reported, vibrissa deflection evoked robust neural responses that consistently adapted to stimulus rates >/=3 Hz. In contrast with this low-pass feature of the response, several other characteristics of the response revealed bandpass response properties. While average evoked response amplitudes measured 0-35 ms after stimulus onset typically decreased with increasing frequency, the later components of the response (>15 ms post stimulus) were augmented at frequencies between 3 and 10 Hz. Further, during the steady state, both rate and temporal measures of neural activity, measured as total spike rate or vector strength (a measure of temporal fidelity of spike timing across cycles), showed peak signal values at 5-10 Hz. A minimal biophysical network model of SI layer IV, consisting of an excitatory and inhibitory neuron and thalamocortical input, captured the spike rate and vector strength band-pass characteristics. Further analyses in which specific elements were selectively removed from the model suggest that slow inhibitory influences give rise to the band-pass peak in temporal precision, while thalamocortical adaptation can account for the band-pass peak in spike rate. The presence of these band-pass characteristics may be a general property of thalamocortical circuits that lead rodents to target this frequency range with their whisking behavior.
Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model

Cuprizone administration in mice provides a reproducible model of demyelination and spontaneous remyelination, and has been useful in understanding important aspects of human disease, including multiple sclerosis. In this study, we apply high spatial resolution quantitative MRI techniques to establish the spatio-temporal patterns of acute demyelination in C57BL/6 mice after 6 weeks of cuprizone administration, and subsequent remyelination after 6 weeks of post-cuprizone recovery. MRI measurements were complemented with Black Gold II stain for myelin and immunohistochemical stains for associated tissue changes. Gene expression was evaluated using the Allen Gene Expression Atlas. Twenty-five C57BL/6 male mice were split into control and cuprizone groups; MRI data were obtained at baseline, after 6 weeks of cuprizone, and 6 weeks post-cuprizone. High-resolution (100μm isotropic) whole-brain coverage magnetization transfer ratio (MTR) parametric maps demonstrated concurrent caudal-to-rostral and medial-to-lateral gradients of MTR decrease within corpus callosum (CC) that correlated well with demyelination assessed histologically. Our results show that demyelination was not limited to the midsagittal line of the corpus callosum, and also that opposing gradients of demyelination occur in the lateral and medial CC. T2-weighted MRI gray/white matter contrast was strong at baseline, weak after 6 weeks of cuprizone treatment, and returned to a limited extent after recovery. MTR decreases during demyelination were observed throughout the brain, most clearly in callosal white matter. Myelin damage and repair appear to be influenced by proximity to oligodendrocyte progenitor cell populations and exhibit an inverse correlation with myelin basic protein gene expression. These findings suggest that susceptibility to injury and ability to repair vary across the brain, and whole-brain analysis is necessary to accurately characterize this model. Whole-brain parametric mapping across time is essential for gaining a real understanding of disease processes in-vivo. MTR increases in healthy mice throughout adolescence and adulthood were observed, illustrating the need for appropriate age-matched controls. Elucidating the unique and site-specific demyelination in the cuprizone model may offer new insights into in mechanisms of both damage and repair in human demyelinating diseases.
White Matter Injury in Term Newborns With Neonatal Encephalopathy

White matter injury (WMI) is the characteristic pattern of brain injury detected on magnetic resonance imaging in the premature newborn. Focal noncystic WMI is increasingly recognized in populations of term newborns. The aim of this study was to describe the occurrence of focal noncystic WMI in a cohort of 48 term newborns with encephalopathy studied with magnetic resonance imaging at 72 ± 12 h of life, and to identify clinical risk factors for this pattern of injury. Eleven newborns (23%; 95% CI 11–35) were found to have WMI (four minimal, three moderate, and four severe). In 10 of the 11 newborns, the WMI was associated with restricted diffusion on apparent diffusion coefficient maps. An increasing severity of WMI was associated with lower gestational age at birth (p = 0.05), but not lower birth weight. Newborns with WMI had milder encephalopathy and fewer clinical seizures relative to other newborns in the cohort. Other brain injuries were seen in three of the 11 newborns: basal nuclei predominant pattern of injury in one and cortical strokes in two. These findings suggest that WMI in the term newborn is acquired near birth and that the state of brain maturation is an important determinant of this pattern of brain injury.
SpotON: An Indoor 3D Location Sensing Technology Based on RF Signal Strength

Providing a reliable technology and architecture for determining the location of real world objects and people will undoubtedly enable applications, customization, and inference not currently possible. This paper documents the creation of SpotON, a new tagging technology for three dimensional location sensing based on radio signal strength analysis. Although there are many aspects to the topic of location sensing and several of them will be briefly discussed, this paper is primarily concerned with the hardware and embedded system development of such a system.
Effects of Silymarin on the In Vivo Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats

Herein, the effect of silymarin pretreatment on the pharmacokinetics of simvastatin in rats was evaluated. To ensure the accuracy of the results, a rapid and sensitive UPLC–MS/MS method was established for simultaneous quantification of simvastatin (SV) and its active metabolite simvastatin acid (SVA). This method was applied for studying the pharmacokinetic interactions in rats after oral co-administration of silymarin (45 mg/kg) and different concentrations of SV. The major pharmacokinetic parameters, including Cmax, tmax, t1/2, mean residence time (MRT), elimination rate constant (λz) and area under the concentration-time curve (AUC0–12h), were calculated using the non-compartmental model. The results showed that the co-administration of silymarin and SV significantly increased the Cmax and AUC0–12h of SVA compared with SV alone, while there was no significant difference with regards to Tmax and t1/2. However, SV pharmacokinetic parameters were not significantly affected by silymarin pretreatment. Therefore, these changes indicated that drug-drug interactions may occur after co-administration of silymarin and SV.
Partially Observable Total-Cost Markov Decision Processes with Weakly Continuous Transition Probabilities

This paper describes sufficient conditions for the existence of optimal policies for Partially Observable Markov Decision Processes (POMDPs) with Borel state, observation, and action sets and with the expected total costs. Action sets may not be compact and one-step cost functions may be unbounded. The introduced conditions are also sufficient for the validity of optimality equations, semi-continuity of value functions, and convergence of value iterations to optimal values. Since POMDPs can be reduced to Completely Observable Markov Decision Processes (COMDPs), whose states are posterior state distributions, this paper focuses on the validity of the above mentioned optimality properties for COMDPs. The central question is whether transition probabilities for a COMDP are weakly continuous. We introduce sufficient conditions for this and show that the transition probabilities for a COMDP are weakly continuous, if transition probabilities of the underlying Markov Decision Process are weakly continuous and observation probabilities for the POMDP are continuous in the total variation. Moreover, the continuity in the total variation of the observation probabilities cannot be weakened to setwise continuity. The results are illustrated with counterexamples and examples.
Optimal infinite horizon control for probabilistic Boolean networks

External control of a genetic regulatory network is used for the purpose of avoiding undesirable states, such as those associated with disease. Heretofore, intervention has focused on finite-horizon control, i.e., control over a small number of stages. This paper considers the design of optimal infinite-horizon control for context-sensitive probabilistic Boolean networks (PBNs). It can also be applied to instantaneously random PBNs. The stationary policy obtained is independent of time and dependent on the current state. We concentrate on discounted problems with bounded cost per stage and on average-cost-per-stage problems. These formulations are used to generate stationary policies for a PBN constructed from melanoma gene-expression data. The results show that the stationary policies obtained by the two different formulations are capable of shifting the probability mass of the stationary distribution from undesirable states to desirable ones
A Multi-Stage Plasmodium vivax Malaria Vaccine Candidate Able to Induce Long-Lived Antibody Responses Against Blood Stage Parasites and Robust Transmission-Blocking Activity

Malaria control and interventions including long-lasting insecticide-treated nets, indoor residual spraying, and intermittent preventative treatment in pregnancy have resulted in a significant reduction in the number of Plasmodium falciparum cases. Considerable efforts have been devoted to P. falciparum vaccines development with much less to P. vivax. Transmission-blocking vaccines, which can elicit antibodies targeting Plasmodium antigens expressed during sexual stage development and interrupt transmission, offer an alternative strategy to achieve malaria control. The post-fertilization antigen P25 mediates several functions essential to ookinete survival but is poorly immunogenic in humans. Previous clinical trials targeting this antigen have suggested that conjugation to a carrier protein could improve the immunogenicity of P25. Here we report the production, and characterization of a vaccine candidate composed of a chimeric P. vivax Merozoite Surface Protein 1 (cPvMSP1) genetically fused to P. vivax P25 (Pvs25) designed to enhance CD4+ T cell responses and its assessment in a murine model. We demonstrate that antibodies elicited by immunization with this chimeric protein recognize both the erythrocytic and sexual stages and are able to block the transmission of P. vivax field isolates in direct membrane-feeding assays. These findings provide support for the continued development of multi-stage transmission blocking vaccines targeting the life-cycle stage responsible for clinical disease and the sexual-stage development accountable for disease transmission simultaneously.
Trap-Door Incision for Penetrating Thoracic Trauma: An Obsolete Approach?

Penetrating injuries to the subclavian vessels are uncommon and very severe lesions. They are difficult to expose and carry a high mortality. “Trap-door” incisions have lately been dismissed as too mutilating for the occasional victim of a penetrating thoracic trauma with massive bleeding difficult that is to expose. We present a case of severe bleeding from a stab wound in the left subclavicular area in a heavy-built patient where a “trap-door” incision proved inevitable to expose and repair the injury, and most probably saved his life.
Editorial on epidemiology of HIV in China was misleading

EDITOR—Zhang and Ma's editorial paints a somewhat misleading and incomplete picture of the epidemiology of HIV in China.1 Firstly, the numbers of HIV infections need to be seen in terms of percentages. Even if the highest current estimate of 1 million infections nationwide is used, this converts to an overall rate of around 0.07%. The male: female ratio is 4:1 and unlike almost any other country most of the people affected (80%) are residents of rural areas. At present four provinces (out of 31) account for 77% of …
Anytime spatially coupled codes for relay channel

In this paper, we study linear anytime codes for the half duplex relay channel. We design anytime codes based on spatially coupled repeat-accumulate (SC-RA) codes. Through finite-length analysis and simulation results, we find that anytime SC-RA codes perform better than existing anytime codes. Furthermore, anytime SC-RA codes allow simple encoding compared to existing anytime spatially coupled low-density parity-check (LDPC) codes. Based on SC-RA codes, we design a bilayer anytime structure suitable for relaying networks with the decode-and-forward strategy. Using asymptotic analysis, we show that the proposed code structure achieves desired anytime properties.
This is how we do it: Answer Reranking for Open-domain How Questions with Paragraph Vectors and Minimal Feature Engineering

We present a simple yet powerful approach to non-factoid answer reranking whereby question-answer pairs are represented by concatenated distributed representation vectors and a multilayer perceptron is used to compute the score for an answer. Despite its simplicity, our approach achieves state-of-the-art performance on a public dataset of How questions, outperforming systems which employ sophisticated feature sets. We attribute this good performance to the use of paragraph instead of word vector representations and to the use of suitable data for training these representations.