Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of blockage ratio on thermal performance of delta-winglet vortex generators

The impact of double-sided delta-winglet tape (DWTs) inserts on convective heat transfer and friction behaviors in a tube was experimentally investigated. Three DWTs with ratios of winglet-height (b) to inner tube diameter (di) called blockage ratio (Rb) of 0.28, 0.35 and 0.42 were tested and their performance was compared to that of a longitudinal strip and plain tube under similar test flow conditions. Experiments were conducted over a wide range of flow rates, 3.35 × 10−5–8.33 × 10−5 m3/s, which correspond to 5500 ≤ Reynolds number (Re) ≤ 14,500 in the 14.3 mm i.d. tube. The results revealed that using DWTs dramatically increased the Nusselt number (Nu) by as much as 364.3% and the friction factor (f) by 15.5 times compared with those of a plain tube. Thermal performance (η) increased with a corresponding increase in Rb. The highest thermal performance (η) obtained was 1.4. Showing a notable improvement on the thermal performance of the system, DWTs are proposed as a favorable insert device.
Process Tracking Results from the Treatwell 5-a-Day Worksite Study

Purpose. To report findings from Treatwell 5-a-Day process tracking. Design. Worksites were randomly assigned to a minimal intervention control, worksite-only condition, or worksite-plus-family condition. Setting. Twenty-two small community health centers in Massachusetts. Subjects. Employees of the community health centers. Intervention. Both intervention conditions included the formation of employee advisory boards; activities such as nutrition discussions and taste tests targeting individual behavior change; and point-of-purchase labeling as an environmental strategy. Worksite-plus-family sites incorporated activities such as family contests, campaigns, and picnics. Measures. Documentation of the number and type of activities for extent of implementation; number of participants in activities for reach; program awareness and participation from the follow-up employee survey (n = 1306, representing 76% [range, 56%–100%] of the sample); change in fruit and vegetable consumption from a comparison between the follow-up and baseline surveys (n = 1359, representing 87% [range, 75%–100%] of the sample). Results. A higher number of activities per employee was significantly correlated with greater program awareness (. 68; p = . 006) and greater change in fruit and vegetable consumption (.55; p = .04). Greater participation in activities was significantly correlated with greater awareness (.67; p = .007), higher participation (.61; p = .02), and increase in fruit and vegetable consumption. (.55; p = .04). Conclusions. These results provide quantitative indicators of a dose-response relationship between the number of intervention activities per employee and higher percentage of employee participation and observed increases in fruit and vegetable consumption.
Effects of tetrodotoxin on osmotically stimulated central and peripheral vasopressin and oxytocin release.

Tetrodotoxin (TTX) was used to (1) distinguish between axonal and dendritic/somatic release of vasopressin (VP) and oxytocin (OT) within the supraoptic nucleus (SON) and (2) to determine whether neuronal inputs trigger intranuclear peptide release in the response to osmotic stimulation. Microdialysis was used to administer TTX (10(-6) M or 10(-4)M) bilaterally into the SON with simultaneous monitoring of central and peripheral peptide release and mean arterial pressure in urethane-anesthetized male rats. Osmotic stimuli were given via the microdialysis probe (1 M NaCl-artificial CSF) or injected intraperitoneally (3.5 M NaCl; 600 mu l/100 g b.w.) SON perfusion with TTX did not alter basal intranuclear VP or OT release or the intranuclear peptide response to direct NaCl stimulation of the SON. However, TTX treatment abolished the effect of peripheral osmotic stimulation on central peptide release. Basal plasma peptide levels were significantly reduced by TTX, e.g. decreases of 94.8 and 75.8% for VP and OT, respectively. TTX also blocked the peripheral endocrine and cardiovascular responses to both modes of osmotic stimulation. The TTX insensitivity of directly stimulated intranuclear release suggests nonsynaptic peptide release from dendrites and/or cell bodies. The ability of TTX to abolish the central peptide response to systemic osmotic stimulation demonstrates that intranuclear release is a part of a cascade produced by osmotic activation of multisynaptic pathways.
Multiplex ligation-dependent probe amplification assay identifies additional copy number changes compared with R-band karyotype and provide more accuracy prognostic information in myelodysplastic syndromes

Cytogenetic analysis provides important diagnostic and prognostic information for patients with Myelodysplastic syndromes (MDS) and plays an essential role in the International Prognostic Scoring System (IPSS) and the revised International Prognostic Scoring System (IPSS-R). Multiplex ligation-dependent probe amplification (MLPA) assay is a recently developed technique to identify targeted cytogenetic aberrations in MDS patients. In the present study, we evaluated the results obtained using an MLPA assay in 437 patients with MDS to determine the efficacy of MLPA analysis. Using R-banding karyotyping, 45% (197/437) of MDS patients had chromosomal abnormalities, whereas MLPA analysis detected that 35% (153/437) of MDS cases contained at least one copy-number variations (CNVs) . 2/5 individuals (40%) with R-band karyotype failures had trisomy 8 detected using only MLPA. Clonal cytogenetic abnormalities were detected in 20/235 (8.5%) MDS patients with a normal R-band karyotype, and 12/20 (60%) of those patients were reclassified into a higher-risk IPSS-R prognostic category. When sequencing and cytogenetics were combined, the fraction of patients with MDS-related oncogenic lesions increased to 87.3% (233/267 cases). MLPA analysis determined that the median OS of patients with a normal karyotype (n=218) was 65 months compared with 27 months in cases with an aberrant karyotype (P=0.002) in 240 patients with normal or failed karyotypes by R-banding karyotyping. The high-resolution MPLA assay is an efficient and reliable method that can be used in conjunction with R-band karyotyping to detect chromosomal abnormalities in patients with suspected MDS. MLPA may also provide more accurate prognostic information.
Contingent Preferences and the Sure-Thing Principle : Revisiting Classic Anomalies in the Laboratory ∗

We formalize an aspect of hypothetical thinking first pointed out by Savage–who referred to it informally as the sure-thing principle (STP)–and show that it underlies many of the classic anomalies in decision and game theory. We perform an experimental test of STP and find that indeed some of the most common anomalies found in the laboratory, including overbidding in auctions, naive voting in elections, and both Ellsberg and Allais types of paradoxes can in large part be attributed to the failure of the type of hypothetical thinking
Controller adherence following hospital discharge in high risk children: A pilot randomized trial of text message reminders

ABSTRACT Objective: To assess the feasibility of a mobile health, inhaled corticosteroid (ICS) adherence reminder intervention and to characterize adherence trajectories immediately following severe asthma exacerbation in high-risk urban children with persistent asthma. Methods: Children aged 2–13 with persistent asthma were enrolled in this pilot randomized controlled trial during an asthma emergency department (ED) visit or hospitalization. Intervention arm participants received daily text message reminders for 30 days, and both arms received electronic sensors to measure ICS use. Primary outcomes were feasibility of sensor use and text message acceptability. Secondary outcomes included adherence to prescribed ICS regimen and 30-day adherence trajectories. Group-based trajectory modeling was used to examine adherence trajectories. Results: Forty-one participants (mean age 5.9) were randomized to intervention (n = 21) or control (n = 20). Overall, 85% were Black, 88% had public insurance, and 51% of the caregivers had a high school education or less. Thirty-two participant families (78%) transmitted medication adherence data; of caregivers who completed the acceptability survey, 25 (96%) chose to receive daily reminders beyond that study interval. Secondary outcome analyses demonstrated similar average daily adherence between groups (intervention = 36%; control = 32%, P = 0.73). Three adherence trajectories were identified with none ever exceeding 80% adherence. Conclusions: Within a high-risk pediatric cohort, electronic monitoring of ICS use and adherence reminders delivered via text message were feasible for most participants, but there was no signal of effect. Adherence trajectories following severe exacerbation were suboptimal, demonstrating an important opportunity for asthma care improvement.
Performance evaluation of a throughput-aware framework for ensemble dataassimilation: the case of NICAM-LETKF

Abstract. In this paper, we propose the design and implementation of an ensemble data assimilation (DA) framework for weather prediction at a high resolution and with a large ensemble size. We consider the deployment of this framework on the data throughput of file input/output (I/O) and multi-node communication. As an instance of the application of the proposed framework, a local ensemble transform Kalman filter (LETKF) was used with a Non-hydrostatic Icosahedral Atmospheric Model (NICAM) for the DA system. Benchmark tests were performed using the K computer, a massive parallel supercomputer with distributed file systems. The results showed an improvement in total time required for the workflow as well as satisfactory scalability of up to 10 K nodes (80 K cores). With regard to high-performance computing systems, where data throughput performance increases at a slower rate than computational performance, our new framework for ensemble DA systems promises drastic reduction of total execution time.
Atomistic simulations of radiation damage in amorphous metal alloys

While numerous fundamental studies have characterized the atomic-level radiation response mechanisms in irradiated crystalline alloys, comparatively little is known regarding the mechanisms of radiation damage in amorphous alloys. Knowledge of collision cascade dynamics is lacking, both with respect to the possibility of sub-cascade formation and concerning the types of damage created in individual cascades. This Thesis resolves these knowledge gaps through a systematic simulation study of the radiation response of amorphous metal alloys. Using a molecular dynamics simulation of /2 MeV ion irradiation in a realistic 2 billion-atom molecular dynamics simulation in amorphous Cu₅₀Nb₅₀, I show that radiation creates isolated nanometer-scale zones with rapidly quenching liquids. Quenched liquids reach large pressures and emit stress pulses that trigger polarized plastic deformation in adjacent material. In order to identify liquid zones in irradiated amorphous Cu₅₀Nb₅₀, I use molecular dynamics simulations to characterize the properties and glass transition temperature of uniform liquid Cu-Nb alloys. I show that radiation-induced liquid zones rapidly quench to material with the same properties as a uniform liquid quenched at an equivalent quench rate approaching 1014 K/s. These "super-quenched zones" (SQZs) are approximately 10 nm in diameter and provide a mechanistic explanation for radiation-induced swelling and ductilization in metallic glasses. The identification of plasticity adjacent to SQZs is an unexpected damage mechanism that could prove a limiting factor for the application of amorphous alloys in radiation environments. To aid selection of amorphous alloys with resistance to collision-induced plasticity, I formulate a micro-mechanical model for collision-induced plasticity in irradiated metallic glasses. The analytical model successfully ranks the damage-resistance of irradiated Cu- Nb alloys and should enable selection of amorphous alloys with optimized radiation tolerance. Finally, through characterization of quenched Cu₅₀Nb₅₀, I reveal that glass transition in Cu₅₀Nb₅₀ occurs by gelation due to formation of a mechanically stiff, percolating network of atoms with icosahedral local packing at the interfaces between compositionally enriched regions. These features of glass transition are similar to gelation processes in polymeric and colloidal gels and suggest new approaches for understanding glass transition in bulk metallic glasses.
Phosphodiesterase inhibitors in inflammatory bowel disease

Inflammatory bowel disease (IBD) is fundamentally a relapsing and remitting disease appearing in forms of ulcerative colitis (UC) or Crohn's disease (CD) with a non-well-known etiology. With the hope to prevent adverse drug events and to increase the efficacy of therapies for IBD, in the recent years, other than new monoclonal antibodies such as infliximab, the novel phosphodiesterase inhibitors (PDEIs) have been introduced. Among PDE4Is, rolipram, OPC-6535, mesopram, roflumilast and tetomilast have shown beneficial effects in experimental colitis. Unfortunately until now, human studies have not been successful in showing significant superiority of PDE4Is in the treatment of IBD. Parallel with discovery of PDE4Is and their anti-inflammatory properties, inhibiting other PDE isoenzymes in immune and proinflammatory cells is on the way. PDE7Is have shown synergistic effect with PDE4Is and they may act similar to PDE3Is in experimental settings. Sildenafil as the PDE5I has shown good effects in experimental colitis by balancing oxidant–antioxidant status. Although the present data about PDE superfamily and their specific roles in gastrointestinal tract is limited but inhibitors of PDE4, PDE5 and PDE7 seem good candidates as the next generation of effective drugs. The synergistic anti-inflammatory effect of PDE4Is and PDE7Is is also important.
Illusory Recovery: Are Recovered Children With Early Language Delay at Continuing Elevated Risk?

Purpose To examine the later development of language and literacy of children who had delayed language at age 2 but were in the normal range at age 4. Method Longitudinal data were analyzed from 3,598 pairs of twins participating in the Twins Early Development Study (TEDS). Six hundred thirty-three twins (8.8%) were delayed at age 2 based on parent-reported expressive vocabulary, and of these, 373 (59.0%) were classified as recovered based on 4-year measures. Each recovered 4-year-old was matched on vocabulary, gender, and zygosity to another 4-year-old without a history of early delay. Results Although the recovered group was below the mean for the total TEDS sample on measures of language at ages 7 and 12, there were no significant differences between the recovered and matched groups. Within the recovered group, it was not possible to predict outcome at better than a chance level. Conclusions Children who appear to have recovered by age 4 from early delay are at modest risk for continuing difficulties, but this appears to be no higher than the risk for other 4-year-olds with equivalent scores, reflecting the continuing variability in longitudinal outcome after age 4. All children in the low normal range at age 4 merit continuing monitoring.
Predicting the use of corporal punishment: Child aggression, parent religiosity, and the BDNF gene

Corporal punishment (CP) has been associated with deleterious child outcomes, highlighting the importance of understanding its underpinnings. Although several factors have been linked with parents' CP use, genetic influences on CP have rarely been studied, and an integrative view examining the interplay between different predictors of CP is missing. We focused on the separate and joint effects of religiosity, child aggression, parent's gender, and a valine (Val) to methionine (Met) substitution in the brain-derived neurotrophic factor (BDNF) gene. Data came from a twin sample (51% male, aged 6.5 years). We used mothers' and fathers' self-reports of CP and religiosity, and the other parent's report on child aggression. Complete data were available for 244 mothers and their 466 children, and for 217 fathers and their 409 children. The random split method was employed to examine replicability. For mothers, only the effect of religiosity appeared to replicate. For fathers, several effects predicting CP use replicated in both samples: child aggression, child sex, religiosity, and a three-way (GxExE) interaction implicating fathers' BDNF genotype, child aggression and religiosity. Religious fathers who carried the Met allele and had an aggressive child used CP more frequently; in contrast, secular fathers' CP use was not affected by their BDNF genotype or child aggression. Results were also repeated longitudinally in a subsample with age 8-9 data. Findings highlight the utility of a bio-ecological approach for studying CP use by shedding light on pertinent gene-environment interaction processes. Possible implications for intervention and public policy are discussed.
Change in the diagnosis of inflammatory bowel disease: a hospital-based cohort study from Korea

Background/Aims Accurately diagnosing inflammatory bowel disease (IBD) remains a challenge, but is crucial for providing proper management for affected patients. The aim of the present study was to evaluate the frequency of change in diagnosis in Korean patients who were referred to our institution with a diagnosis of IBD. Methods We enrolled 1,444 patients diagnosed with ulcerative colitis (UC) and 1,452 diagnosed with Crohn's disease (CD), who had been referred to the Asan Medical Center between January 2010 and December 2014. These patients were assessed and subsequently classified as having UC, CD, indeterminate colitis, possible IBD, or non-IBD. Results During a median follow-up of 15.9 months, 400 of the 2,896 patients (13.8%) analyzed in this study experienced a change in diagnosis. A change in diagnosis from UC to CD, or vice-versa, was made in 24 of 1,444 patients (1.7%) and 23 of 1,452 patients (1.6%), respectively. A change to a non-IBD diagnosis was the most common modification; 7.5% (108 of 1444) and 12.7% (184 of 1452) of the patients with a referral diagnosis of UC and CD, respectively, were reclassified as having non-IBD. Among the 292 patients who were ultimately determined not to have IBD, 135 (55 UC and 80 CD cases) had received IBD-related medication. Conclusions There are diagnostic uncertainties and difficulties in relation to IBD. Therefore, precise assessment and systematic follow-up are essential in the management of this condition.
The role of extended defects on the formation of ultra-shallow junctions in ion implanted /sup 11/B/sup +/, /sup 49/BF/sub 2/, /sup 75/As/sup +/ and /sup 31/P/sup +/

Ion implants of /sup 11/B/sup +/ (0.25 keV to 2.0 keV), /sup 49/BF/sub 2//sup +/ (1.1 keV to 8.9 keV), 75As/sup +/ (2.0 keV to 5.0 keV); and /sup 31/P/sup +/ (1.0 keV to 5.0 keV) at a dose of 1e15/cm/sup 2/ were investigated by TEM to determine defect type and concentrations after a 750/spl deg/C, 15 min furnace baseline anneal and then after rapid thermal annealing (RTA) using "slow" and "fast" spike anneals (<0.1 s) at 1050/spl deg/C. Trapped interstitial densities were calculated from the measured defect concentration, type and size and are compared to the observed changes in junction depth. The effect of the changing trapped interstitial densities on transient enhanced diffusion (TED) for various B and BF/sub 2/ implants are discussed. In the case of BF/sub 2/, the combined effect associated with the trapped interstitial density and the residual fluorine level is also discussed. To minimize all other diffusion effects such as oxidation enhanced diffusion (OED), oxygen related diffusion effects and thermal diffusion effects, the B and BF/sub 2/ comparison was conducted on wafers which were "spike" annealed in an ambient of 33 ppm O/sub 2/ in N/sub 2/. For all species a defect free energy threshold is identified where, after the 750/spl deg/C, 15 min (and confirmed at 600/spl deg/C to 800/spl deg/C) furnace base-line anneal, no extended-defects or loops formed (i.e. <1e7/cm/sup 2/). Implants below this threshold allow complete freedom in the choice of RTA conditions to minimize desired sheet resistance and junction depth values without the concern of post-RTA trapped interstitials which could enhance the dopant diffusion during subsequent post-implant processing steps, and for concerns of enhanced leakage current resulting from end-of-range (EOR) damage. Examples of how "spike" anneals in low ppm O/sub 2/ in N/sub 2/ ambients on implants below this energy threshold can be employed to optimize sheet resistance (R/sub 5/) and junction depth (X/sub j/) are presented for: /sup 49/BF/sub 2/ at 2.2 keV (R/sub 5/ of 406 Ohms/sq., electrical X/sub j/ of 386 /spl Aring/); /sup 49/BF/sub 2/ at 1.1 keV (R/sub 5/ of 669 Ohms/sq., electrical X/sub j/ of 234 /spl Aring/); and 0.25 keV /sup 11/B (R/sub 5/ of 434 Ohms/sq., electrical X/sub j/ of 419 /spl Aring/).
Morphological and morphometric analysis of accessory mental foramen in dry human mandibles of south indian population

Background: Mental foramen (MF) is an important landmark for administration of local anesthesia in surgical procedures involving the mandible. Additional mental foramina, called accessory mental foramina (AMF) transmitting branches of mental nerve, have been reported. Detection of AMFs in presurgical imaging may reduce postoperative pain in dental surgical procedures. Aim: The aim of the study was to study the incidence and morphometric analysis of accessory MF in the dry human mandibles of South Indian population. Materials and Methods: Two hundred and sixty dry human mandibles were studied for the presence, location, shape of AMF, and its relation to MF. The horizontal diameter of AMF, and its distance from symphysis menti, the posterior border of mandible and from the base of mandible were measured and statistically analyzed. Results and Conclusions: In our study, AMF were present in 8.85% mandibles (unilateral - 7.6% [4.6% - left, 2.69% - right] and bilateral 1.6%). The most common position was below the second premolar (48.1%). AMF were round in shape (74%) and was often located either superomedial or inferolateral to MF. Their transverse diameter ranged from 0.5 to 1 mm. The AMF were situated at a mean distance of 2.96 mm from MF, 23.47 mm from symphysis menti, 11.24 mm from the lower border of the body of the mandible, and 57.35 mm from the posterior border of ramus of mandible. The knowledge of the presence of AMF and its dimensions would enable the clinicians to do mandibular procedures carefully and avoid injury to the branches of mental nerve that may be passing through it.
Stakeholder engagement and biodiversity conservation challenges in social-ecological systems: Some insights from biosphere reserves in western Africa and France

Biosphere reserves are an example of social-ecological systems that combine biodiversity conservation and socioeconomic development with knowledge generation and dissemination (both scientific and local). We review lessons learned from case studies biosphere reserves in western African and France, highlighting the importance of early stakeholder engagement to build knowledge for achieving sustainable development. We discuss the evolution of the concept of biosphere reserves and its application over time in different socioeconomic and cultural settings. The diversity of stakeholders and their different needs and perceptions about nature conservation complicate implementation processes, sometimes resulting in conflicts about the objectives and zonation of biosphere reserves. Dialogue among the different stakeholders must start at an early planning phase and be based on the principle of social and ecological solidarity. Dialogue must then be pursued, formalized, ritualized, and translated both in terms of biosphere reserve management and in terms of political support. Tools and methods exist that can facilitate such dialogue and colearning.