Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance Analysis of Nanoelectromechanical Relay-Based Field-Programmable Gate Arrays

The energy consumption of field-programmable gate arrays (FPGA) is dominated by leakage currents and dynamic energy associated with programmable interconnect. An FPGA built entirely from nanoelectromechanical (NEM) relays can effectively eliminate leakage energy losses, reduce the interconnect dynamic energy, operate at temperatures >225 °C and tolerate radiation doses in excess of 100 Mrad, while hybrid FPGAs comprising both complementary metal-oxide-semiconductor (CMOS) transistors and NEM relays (NEM-CMOS) have the potential to realize improvements in performance <italic>and</italic> energy efficiency. Large-scale integration of NEM relays, however, poses a significant engineering challenge due to the presence of moving parts. We discuss the design of FPGAs utilizing NEM relays based on a heterogeneous 3-D integration scheme, and carry out a scaling study to quantify key metrics related to performance and energy efficiency in both NEM-only and NEM-CMOS FPGAs. We show how the integration scheme has a profound effect on these metrics by changing the length of global wires. The scaling regime beyond which net performance and energy benefits is seen in NEM-CMOS over a baseline 90 nm CMOS technology is defined by an effective relay beam length of 0.5 <inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula>, on-resistance of 200 <inline-formula> <tex-math notation="LaTeX">$\text{k}\Omega$ </tex-math></inline-formula>, and a via pitch of 0.4 <inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula>, all achievable with existing process technology. For ultra-low energy applications that are not performance critical, NEM-only FPGAs can provide close to <inline-formula> <tex-math notation="LaTeX">$15\times$ </tex-math></inline-formula> improvement in energy efficiency.
The Longitudinal Associations Among Temperament, Parenting, and Turkish Children's Prosocial Behaviors.

In Turkey, responsive behaviors toward kin are expected from children. Despite this, we know little about the factors that influence young Turkish children's prosocial behaviors. The goal was to explore how temperament and parenting are related to children's prosocial development in Turkey. A total of 293 Turkish children (Mage = 49 months; 48.12% females) were followed up for 3 years. Mothers completed measures of their child's prosocial behaviors, as well as measures of their warmth, inductive reasoning, and the child's approach and reactivity. Maternal warmth predicted children's reactivity, and maternal induction predicted children's sociability. Children's reactivity was inversely related to children's helping behavior and sociability was related to more prosocial behavior. Maternal warmth had indirect links with helping through lessening children's reactivity.
29 GHRELIN , LIPID METABOLISM , AND METABOLIC SYNDROME

Ghrelin is a 28-aminoacid peptide predominantly, but not exclusively, produced by stomach’s X/A-like cells that acts through the growth hormone secretagogue receptor (GHS-R). It is the only peptidic hormone stimulating appetite and adiposity. Although ghrelin has a wide range of actions in the body, including the regulation of glucose homeostasis, regulation of gastric and pancreatic activity, and stimulation of growth hormone or cardiovascular activities, its main role is the regulation of energy balance. In fact, the ghrelin system has recently become an interesting target to design chemicals against obesity and related comorbidities. Fatty acids, which play a crucial role in the metabolic syndrome, are essential mediators for the actions of ghrelin on both food intake and adiposity. In this review we will summarize the current knowledge about ghrelin actions and signaling pathways on metabolic homeostasis and energy balance with special emphasis on those related to its effects at hypothalamic level.
Insight into the Significance of Aspergillus fumigatus cyp51A Polymorphisms

ABSTRACT Triazole antifungal compounds are the first treatment choice for invasive aspergillosis. However, in the last decade the rate of azole resistance among Aspergillus fumigatus strains has increased notoriously. The main resistance mechanisms are well defined and mostly related to point mutations of the azole target, 14-α sterol demethylase (cyp51A), with or without tandem repeat integrations in the cyp51A promoter. Furthermore, different combinations of five Cyp51A mutations (F46Y, M172V, N248T, D255E, and E427K) have been reported worldwide in about 10% of all A. fumigatus isolates tested. The azole susceptibility profile of these strains shows elevated azole MICs, although on the basis of the azole susceptibility breakpoints, these strains are not considered azole resistant. The purpose of the study was to determine whether these cyp51A polymorphisms (single nucleotide polymorphisms [SNPs]) are responsible for the azole susceptibility profile and whether they are reflected in a poorer azole treatment response in vivo that could compromise patient treatment and outcome. A mutant with a cyp51A deletion was generated and became fully susceptible to all azoles tested. Also, three cyp51A gene constructions with different combinations of SNPs were generated and reintroduced into an azole-susceptible wild-type (WT) strain (the ΔakuBKU80 strain). The alternative model host Galleria mellonella was used to compare the virulence and voriconazole response of G. mellonella larvae infected with A. fumigatus strains with WT cyp51A or cyp51A with SNPs. All strains were pathogenic in G. mellonella larvae, although they did not respond similarly to voriconazole therapeutic doses. Finally, the full genomes of these strains were sequenced and analyzed in comparison with those of A. fumigatus WT strains, revealing that they belong to different strain clusters or lineages.
Comparative Evaluation of Shape Memory Alloy Constitutive Models with Test Data

An experimental-theoretical study of Shape Memory Alloys (SMA) wires was undertaken in order to use the SMA wires in the active tuning of rotating composite shafts. Four constitutive models are compared and validated with experimental results. The four models compared were developed by Tanaka, Liang and Rogers, Boyd and Lagoudas, and Brinson. Careful testing of SMA wires was carried out to determine the necessary coefficients for the four constitutive models. Coefficients such as the Young's modulus for the martensite and austenite phase and the four phase transformation temperatures were determined. All models showed good qualitative trends; however quantitatively, all except one fared unsatisfactorily. The model developed by Brinson showed good correlation with experimental data.
Hepatitis E Virus in Cambodia: Prevalence among the General Population and Complete Genome Sequence of Genotype 4

Hepatitis E virus (HEV) is a growing public health problem in many countries. In this study, we investigated HEV seroprevalence among the general population in the Siem Reap province, Cambodia, and performed HEV genetic analysis with the aim to develop an HEV prevention strategy. This seroepidemiological cross-sectional study conducted from 2010 to 2014 included 868 participants from four different locations in Siem Reap province, Cambodia. They answered questionnaires and provided blood samples for the analysis of hepatitis virus infections. Among the participants (360 men and 508 women; age range, 7–90 years), the prevalence of anti-HEV IgG was 18.4% (95% confidence interval: 15.9–21.0); HEV RNA was detected in two participants (0.23%) and was classified as genotype 3 and 4. Full-length genome of the genotype 4 isolate, CVS-Sie10, was sequenced; it contained 7,222 nucleotides and three ORFs and demonstrated high sequence identity with the swine China isolates swGX40 (95.57%), SS19 (94.37%), and swDQ (91.94%). Multivariate logistic regression analysis revealed that men, elderly people, and house workers were risk groups significantly associated with the positivity for anti-HEV IgG. This is the first report on the detection of HEV genotype 4 in humans in Cambodia and on the complete genome sequence of HEV genotype 4 from this country. Our study demonstrates that new HEV infection cases occur frequently among the general population in Cambodia, and effective preventive measures are required.
Effects of lactic acid bacteria and smectite after aflatoxin B1 challenge on the growth performance, nutrient digestibility and blood parameters of broilers

This study aimed to investigate the effect of lactic acid bacteria (LAB) and smectite on the growth performance, nutrient digestibility and blood parameters of broilers that were fed diets contaminated with aflatoxin B1 (AFB1 ). A total of 480 newly hatched male Arbor Acres broilers were randomly allocated into four groups with six replicates of 20 chicks each. The broilers were fed diets with the AFB1 (40 μg/kg) challenge or without (control) it and supplemented with smectite (3.0 g/kg) or LAB (4.0 × 1010 CFU/kg) based on the AFB1 diet. The trial lasted for 42 days. The results showed that during days 1-42 of AFB1 challenge, the feed intake (FI) and body weight gain (BWG) were depressed (p < .05). The inclusion of LAB and smectite increased (p < .05) the BWG by 71.58 and 41.89 g/bird, respectively, which reached the level of the control diet (p ≥ .05), but there were no differences (p ≥ .05) in performance between LAB and smectite. LAB and smectite also increased (p < .05) the apparent total tract digestibility of the crude protein. Regarding the blood parameters, AFB1 decreased (p < .05) the levels of red blood cell count, haematocrit, mean corpuscular volume, haemoglobin, albumin and total protein. In the meantime, the AFB1 increased (p < .05) leucocyte counts, urea nitrogen, cholesterol, total bilirubin, creatinine, glutamic-pyruvic transaminase, glutamic oxaloacetic transaminase and alkaline phosphatase. By contrast, LAB and smectite affected (p < .05) these parameters in the opposite direction. It can be concluded that after the AFB1 challenge, LAB and smectite have similar effects on the growth and health of the broilers, suggesting that LAB could be an alternative against AFB1 in commercial animal feeds.
Effect of Resistance Training on Extracellular Matrix Adaptations in Skeletal Muscle of Older Rats

Accumulation of connective tissue, particularly extracellular matrix (ECM) proteins, has been observed in skeletal muscles with advancing age. Resistance training (RT) has been widely recommended to attenuate age-induced sarcopenia, even though its effects on the components that control ECM turnover in skeletal muscles remain to be elucidated. Thus, the aim of this study was to determine the effects of RT on connective tissue content and gene expression of key components of ECM in the skeletal muscles of aged rats. Young (3 mo.) and older (21 mo.) adult male Wistar rats were submitted to a RT protocol (ladder climbing with 65, 85, 95, and 100% load), 3 times a week for 12 weeks. Forty-eight hours post-training, the soleus (SOL) and gastrocnemius (GAS) muscles were dissected for histological and mRNA analysis. RT mitigated the age-associated increase of connective tissue content in both muscles, even though mRNA levels of COL-1 and−3 were elevated in older trained rats. Overall, RT significantly elevated the gene expression of key components of connective tissue deposition (TGFβ and CTGF; MMP-2 and-9; TIMP-1 and−2) in the GAS and SOL muscles of older rats. In conclusion, RT blunted the age-induced accumulation of connective tissue concomitant to the upregulation of genes related to synthesis and degradation of the ECM network in the SOL and GAS muscles of older rats. Although our findings indicate that RT plays a crucial role reducing connective tissue accumulation in aged hindlimb muscles, key components of ECM turnover were paradoxically elevated. The phenotypic responses induced by RT were not accompanied by the gene expression of those components related to ECM turnover.
Fecal bacterial diversity of wild Sichuan snub‐nosed monkeys (Rhinopithecus roxellana)

The gastrointestinal tract of primates harbors a complex microbial community, playing an essential role in the degradation of otherwise indigestible structural carbohydrates. The phylogenetic and functional diversity of the bacterial community in the feces as a surrogate for the gastrointestinal tract of wild Sichuan snub‐nosed monkeys (Rhinopithecus roxellana, N = 6) was characterized based on sequence analysis of 16S rRNA genes. A sex comparison was conducted, with a prior hypothesis that the abundances of the bacterial taxa and/or functional categories associated with energy and nutrient metabolism would be higher in adult females (N = 3) due to the higher reproductive costs compared to adult males (N = 3). Ten phyla were identified in all samples, among which Bacteroidetes and Firmicutes were the predominant. Included in the above two phyla, the members of Prevotellaceae (Prevotella in particular) and Ruminococcaceae were highly abundant, which are common bacteria in the gastrointestinal tract of primates and can degrade various structural carbohydrates such as cellulose, hemicellulose, and pectin. This functionality was in line with the high abundances of the metagenomes associated with carbohydrate metabolism. Consistent with our hypothesis, the abundances of the metagenomes associated with energy metabolism, folding/sorting and degradation, glycan biosynthesis and metabolism, and metabolism of amino acids were higher in adult females relative to adult males. Sex differences were also detected in the bacterial community structure, although no sex differences in the proportions of any bacterial taxa were found likely due to the small sample size. These results suggested that gastrointestinal bacterial communities may aid adult females in increasing energy and nutrition utilization efficiencies compared to adult males. Fecal bacterial communities were found to be more similar between individuals in adult females than in adult males. Our study presented the first examination of the fecal bacterial diversity of a little‐studied, endangered foregut fermenter.
Pancreatic endocrine tumours: mutational and immunohistochemical survey of protein kinases reveals alterations in targetable kinases in cancer cell lines and rare primaries

BACKGROUND Kinases represent potential therapeutic targets in pancreatic endocrine tumours (PETs). PATIENTS AND METHODS Thirty-five kinase genes were sequenced in 36 primary PETs and three PET cell lines: (i) 4 receptor tyrosine kinases (RTK), epithelial growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), tyrosine-protein kinase KIT (KIT), platelet-derived growth factor receptor alpha (PDGFRalpha); (ii) 6 belonging to the Akt/mTOR pathway; and (iii) 25 frequently mutated in cancers. The immunohistochemical expression of the four RTKs and the copy number of EGFR and HER2 were assessed in 140 PETs. RESULTS Somatic mutations were found in KIT in one and ATM in two primary neoplasms. Among 140 PETs, EGFR was immunopositive in 18 (13%), HER2 in 3 (2%), KIT in 16 (11%), and PDGFRalpha in 135 (96%). HER2 amplification was found in 2/130 (1.5%) PETs. KIT membrane immunostaining was significantly associated with tumour aggressiveness and shorter patient survival. PET cell lines QGP1, CM and BON harboured mutations in FGFR3, FLT1/VEGFR1 and PIK3CA, respectively. CONCLUSIONS Only rare PET cases, harbouring either HER2 amplification or KIT mutation, might benefit from targeted drugs. KIT membrane expression deserves further attention as a prognostic marker. ATM mutation is involved in a proportion of PET. The finding of specific mutations in PET cell lines renders these models useful for preclinical studies involving pathway-specific therapies.
Phenomenological investigation of breakdown in oil dielectrics

The physics of low density channel formation due to electrical breakdown in transformer oil is investigated using high speed electrical and optical diagnostics. The experiments done in pulsed and self-breakdown mode utilize a coaxial system with a point/plane axial discharge in transformer oil. Construction of the discharge chamber, oil filtration system and implementation of a matched 50 Ω impedance throughout the system are presented. Preliminary experiments conducted in Univolt 61 and Envirotemp FR3 are compared for base line results for self and pulsed breakdown. Further experiments were conducted in an effort to alter the direction or structure of the low density channels with an applied magnetic field and at lowered hydrostatic pressure. While no change was seen in the low density channels with an applied magnetic field, expansion of the low density channels was recorded in shadowgraphy images. Expansion was seen in a small percentage of anode initiated low density channels but was predominant in the channels initiated from the cathode indicating a channel consisting of a gas or vapor for this polarity. Initial results support previous research that has indicated that current injection leading to the formation of a single bubble is likely the building block for these low density channels for cathode initiated self breakdown. Further experiments were undertaken to compare single bubble dynamics to channel formation. The experiments conclude that low density channels are formed due to the generation of gas or vapor during cathode-initiated breakdown. A correlation between similar characteristics such as lifetime, separation, charge injection and pressure dependence were found. Systematic variation of exposure times and time delays between simultaneous luminosity and shadowgraphy images has also been performed to spatially and temporally resolve the luminosity emitted during prebreakdown events against the low density channels seen in the shadowgraphy images at atmospheric pressure and lowered hydrostatic pressure. Composite imaging of cathode initiated low density channels that have become separated from the cathode, suggest a discharge from the bubble back to the anode occurs and was verified with
The Acceptor Side of Photosystem II Is the Initial Target of Nitrite Stress in Synechocystis sp. Strain PCC 6803

ABSTRACT Nitrite, a common form of inorganic nitrogen (N), can be used as a nitrogen source through N assimilation. However, high levels of nitrite depress photosynthesis in various organisms. In this study, we investigated which components of the photosynthetic electron transfer chain are targeted by nitrite stress in Synechocystis sp. strain PCC 6803 cells. Measurements of whole-chain and photosystem II (PSII)-mediated electron transport activities revealed that high levels of nitrite primarily impair electron flow in PSII. Changes in PSII activity in response to nitrite stress occurred in two distinct phases. During the first phase, which occurred in the first 3 h of nitrite treatment, electron transfer from the primary quinone acceptor (QA) to the secondary quinone acceptor (QB) was retarded, as indicated by chlorophyll (Chl) a fluorescence induction, S-state distribution, and QA− reoxidation tests. In the second phase, which occurred after 6 h of nitrite exposure, the reaction center was inactivated and the donor side of photosystem II was inhibited, as revealed by changes in Chl fluorescence parameters and thermoluminescence and by immunoblot analysis. Our data suggest that nitrite stress is highly damaging to PSII and disrupts PSII activity by a stepwise mechanism in which the acceptor side is the initial target. IMPORTANCE In our previous studies, an alga-based technology was proposed to fix the large amounts of nitrite that are released from NOX-rich flue gases and proved to be a promising industrial strategy for flue gas NOX bioremediation (W. Chen et al., Environ Sci Technol 50:1620–1627, 2016, https://doi.org/10.1021/acs.est.5b04696 ; X. Zhang et al., Environ Sci Technol 48:10497–10504, 2014, https://doi.org/10.1021/es5013824 ). However, the toxic effects of high concentrations of nitrite on algal cells remain obscure. The analysis of growth rates, photochemistry, and protein profiles in our study provides important evidence that the inhibition by nitrite occurs in two phases: in the first phase, electron transfer between QA− and QB is retarded, whereas in the second, the donor side of PSII is affected. This is an excellent example of investigating the “early” inhibitory effects (i.e., within the first 6 h) on the PSII electron transfer chain in vivo. This paper provides novel insights into the mechanisms of nitrite inhibition of photosynthesis in an oxygenic phototrophic cyanobacterium.
Building Better Quality Predictors Using "ε-Dominance"

Despite extensive research, many methods in software quality prediction still exhibit some degree of uncertainty in their results. Rather than treating this as a problem, this paper asks if this uncertainty is a resource that can simplify software quality prediction. For example, Deb's principle of $\epsilon$-dominance states that if there exists some $\epsilon$ value below which it is useless or impossible to distinguish results, then it is superfluous to explore anything less than $\epsilon$. We say that for "large $\epsilon$ problems", the results space of learning effectively contains just a few regions. If many learners are then applied to such large $\epsilon$ problems, they would exhibit a "many roads lead to Rome" property; i.e., many different software quality prediction methods would generate a small set of very similar results. This paper explores DART, an algorithm especially selected to succeed for large $\epsilon$ software quality prediction problems. DART is remarkable simple yet, on experimentation, it dramatically out-performs three sets of state-of-the-art defect prediction methods. The success of DART for defect prediction begs the questions: how many other domains in software quality predictors can also be radically simplified? This will be a fruitful direction for future work.