Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of myrrh and thyme on Trichinella spiralis enteral and parenteral phases with inducible nitric oxide expression in mice

Trichinellosis is a serious disease with no satisfactory treatment. We aimed to assess the effect of myrrh (Commiphora molmol) and, for the first time, thyme (Thymus vulgaris L.) against enteral and encysted (parenteral) phases of Trichinella spiralis in mice compared with albendazole, and detect their effect on inducible nitric oxide synthase (iNOS) expression. Oral administration of 500 mg/kg of myrrh and thyme led to adult reduction (90.9%, 79.4%), while 1,000 mg/kg led to larvae reduction (79.6%, 71.3%), respectively. Administration of 50 mg/kg of albendazole resulted in adult and larvae reduction (94.2%, 90.9%). Positive immunostaining of inflammatory cells infiltrating intestinal mucosa and submucosa of all treated groups was detected. Myrrh-treated mice showed the highest iNOS expression followed by albendazole, then thyme. On the other hand, both myrrh and thyme-treated groups showed stronger iNOS expression of inflammatory cells infiltrating and surrounding encapsulated T. spiralis larvae than albendazole treated group. In conclusion, myrrh and thyme extracts are highly effective against both phases of T. spiralis and showed strong iNOS expressions, especially myrrh which could be a promising alternative drug. This experiment provides a basis for further exploration of this plant by isolation and retesting the active principles of both extracts against different stages of T. spiralis.
A review of feature selection methods with applications

Feature selection (FS) methods can be used in data pre-processing to achieve efficient data reduction. This is useful for finding accurate data models. Since exhaustive search for optimal feature subset is infeasible in most cases, many search strategies have been proposed in literature. The usual applications of FS are in classification, clustering, and regression tasks. This review considers most of the commonly used FS techniques. Particular emphasis is on the application aspects. In addition to standard filter, wrapper, and embedded methods, we also provide insight into FS for recent hybrid approaches and other advanced topics.
Differential expression of VASP in normal lung tissue and lung adenocarcinomas

Background: Vasodilator stimulated phosphoprotein (VASP) is associated with focal adhesions and is thought to have an important role in actin filament assembly and cell motility. We hypothesise that an increase in the expression of VASP is involved in the progression and invasion of lung adenocarcinomas in parallel to tumour progression. A study was undertaken to analyse VASP expression in normal lung tissue and lung adenocarcinomas. Methods: Human lung tissues with adenocarcinomas (n = 26) were used. Normal lung tissue specimens (n = 14) were taken from areas a standard distance (3 cm) from resected adenocarcinomas of patients who underwent surgical lung resection. Adenocarcinomas were classified according to pathological staging and histopathological grades. Tissues were stained for VASP using immunohistochemistry. Results: Normal lung pneumocytes showed no VASP expression while alveolar macrophages had the strongest immunoreactivity for VASP. Bronchial epithelium (surface epithelium, goblet cells) and bronchial gland cells had a very weak immunoreactivity for VASP. Adenocarcinomas had significantly greater VASP expression than normal epithelium (p<0.001). Moreover, VASP expression in adenocarcinomas increased significantly with more advanced tumour stage (p<0.001). Conclusions: The spatial and differential expression of VASP in normal lung tissue and lung adenocarcinomas suggests that it is likely to be involved in the differentiation of normal lung cells to adenocarcinomas. The significant increase in the expression of VASP in adenocarcinomas in parallel to pathological staging suggests that it may regulate the invasive behaviour of lung adenocarcinomas as adenocarcinoma invasion is increased in more advanced tumours.
Resting Heart Rate Variability, Facets of Rumination and Trait Anxiety: Implications for the Perseverative Cognition Hypothesis

The perseverative cognition hypothesis (PCH) posits that perseveration, defined as the repetitive or sustained activation of cognitive representations of a real or imagined stressor, is a primary mechanism linking psychological (or stress) vulnerability with poor health and disease. Resting vagally mediated heart rate variability (vmHRV) is an important indicator of self-regulatory abilities, stress vulnerability and overall health. Those with lower resting vmHRV are more vulnerable to stress, and thus more likely to engage in perseverative cognition and experience subsequent negative mental health outcomes such as anxiety. Recent research suggests that rumination—one of the core mechanisms underlying perseveration—is a construct containing (at least) two maladaptive (depressive and brooding) and one adaptive (reflective) types of rumination. However, to date, research has not examined how the association between resting vmHRV may differ between these three facets of rumination, in addition to these facets’ mechanistic role in linking lower resting vmHRV with greater trait anxiety. The current cross-sectional study explores these relationships in a sample of 203 participants (112 females, 76 ethnic minorities, mean age = 19.43, standard deviation = 1.87). Resting vmHRV was assessed during a 5-min-resting period using an Electrocardiogram (ECG). Both trait rumination (including the three facets) and anxiety were assessed via self-report scales. Significant negative associations were found between resting vmHRV and maladaptive, but not adaptive, forms of perseveration. Similarly, mediation analyses showed a significant indirect relationship between resting vmHRV and anxiety through maladaptive, but not adaptive, facets of rumination. Our findings support the PCH such that those with stress vulnerability, as indexed by lower resting vmHRV, are more likely to engage in maladaptive perseverative cognition and thus experience negative outcomes such as anxiety. Our data also lend a novel outlook on the PCH; resting vmHRV is not related to reflective rumination and thus, this facet of perseveration may be a neutral, but not beneficial, factor in the link between stress vulnerability and psychological well-being.
A role for SUV39H1-mediated H3K9 trimethylation in the control of genome stability and senescence in WI38 human diploid lung fibroblasts

Cellular senescence has been associated with the age-dependent decline in tissue repair and regeneration, the increasing deterioration of the immune system, and the age-dependent increase in the incidence of cancer. Here, we show that senescence of human lung fibroblast WI-38 cells is associated with extensive changes to the gene expression profile, including the differential expression of transcriptional and epigenetic regulators. Among those, SUV39H1 was downregulated in senescent cells, correlated with a decrease in global H3K9 trimethylation, reduced H3K9me3 levels in repetitive DNA sequence regions such as satellites and transposable elements, and increased transcription of these repetitive DNA sequences. This indicates that SUV39H1 plays a role in limiting genomic instability in dividing cells and suggests that SUV39H1 downregulation may contribute to the establishment of senescence by increasing genomic instability. Additionally, the manipulation of SUV39H1 expression levels resulted in altered cell cycle distribution, suggesting a causal role of SUV39H1 in the establishment of cellular senescence. Thus, based on our findings and the results from previous reports, we propose a model in which SUV39H1 downregulation promotes the establishment of cellular senescence.
Anopheles species of the mount Cameroon region: biting habits, feeding behaviour and entomological inoculation rates

There is a lack of data on the Anopheles fauna, its biology and the roles played by different vector species in the transmission of malaria in the mount Cameroon region. The biting habits, feeding behaviour and entomological inoculation rates of different Anopheles species during the dry and rainy season were investigated. A total of 2165 Anopheles was collected, 805 in the rainy season and 1360 in the dry season. Five Anopheles species were identified: Anopheles gambiae s.l. , An. funestus, An. hancocki, An. moucheti and An. nili. An. gambiae, An. funestus and An. hancocki, recorded during both seasons, were the main vectors of malaria in the region. An. gambiae s.s. was the only member of the An. gambiae (Giles) complex. These three species had their peak activity between 1 and 2 am. A human blood index (HBI) of 98.29% was recorded for fed Anopheles. The sporozoite rate, for all vectors together, was significantly higher in the rainy season (9.4%) than in the dry season (4.2%) with all the species infected by Plasmodium falciparum. The average inoculation rate was 0.44 infective bites per man per night, which adds up to 161 infective bites per year in this study area. Analyses of relative abundance and infection rate of malaria vectors at different sites situated along a transect of 20 km during the dry season showed high heterogeneity in biting and sporozoite rates. No malaria vector was caught at 1200 m a.s.l. The mount Cameroon region should be considered an area of high malaria transmission intensity.
50 μm pixel pitch wafer-scale CMOS active pixel sensor x-ray detector for digital breast tomosynthesis

Wafer-scale CMOS active pixel sensors (APSs) have been developed recently for x-ray imaging applications. The small pixel pitch and low noise are very promising properties for medical imaging applications such as digital breast tomosynthesis (DBT). In this work, we evaluated experimentally and through modeling the imaging properties of a 50 μm pixel pitch CMOS APS x-ray detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). A modified cascaded system model was developed for CMOS APS x-ray detectors by taking into account the device nonlinear signal and noise properties. The imaging properties such as modulation transfer function (MTF), noise power spectrum (NPS), and detective quantum efficiency (DQE) were extracted from both measurements and the nonlinear cascaded system analysis. The results show that the DynAMITe x-ray detector achieves a high spatial resolution of 10 mm−1 and a DQE of around 0.5 at spatial frequencies <1 mm−1. In addition, the modeling results were used to calculate the image signal-to-noise ratio (SNRi) of microcalcifications at various mean glandular dose (MGD). For an average breast (5 cm thickness, 50% glandular fraction), 165 μm microcalcifications can be distinguished at a MGD of 27% lower than the clinical value (~1.3 mGy). To detect 100 μm microcalcifications, further optimizations of the CMOS APS x-ray detector, image aquisition geometry and image reconstruction techniques should be considered.
Type II Diabetes Mellitus in Arabic-Speaking Countries

The global epidemic of diabetes has not spared the Arabic-speaking countries, which have some of the highest prevalence of type II diabetes. This is particularly true of the Arab Gulf, a conglomerate of high income, oil-producing countries where prevalence rates are the highest. The prevalence rates among adults of the Arabic speaking countries as a whole range between 4%–21%, with the lowest being in Somalia and the highest in Kuwait. As economic growth has accelerated, so has the movement of the populations to urban centers where people are more likely to adopt lifestyles that embrace increased high-calorie food consumption and sedentary lifestyles. These factors likely contribute to the increased prevalence of obesity and diabetes in the Arabic speaking countries.
Constant-Time Algorithms for Constrained Triangulations on Reconfigurable Meshes

A number of applications in computer-aided manufacturing, CAD, and computer-aided geometric design ask for triangulating pieces of material with defects. These tasks are known collectively as constrained triangulations. Recently, a powerful architecture called the reconfigurable mesh has been proposed: In essence, a reconfigurable mesh consists of a mesh-connected architecture augmented by a dynamically reconfigurable bus system. The main contribution of this paper is to show that the flexibility of the reconfigurable mesh can be exploited for the purpose of obtaining constant-time algorithms for a number of constrained triangulation problems. These include triangulating a convex planar region containing any constant number of convex holes, triangulating a convex planar region in the presence of a collection of rectangular holes, and triangulating a set of ordered line segments. Specifically with a collection of O(n) such objects as input, our algorithms run in O(1) time on a reconfigurable mesh of size n/spl times/n. To the best of our knowledge, this is the first time constant time solutions to constrained triangulations are reported on this architecture.
Microfinance and mobile banking : the story so far

Late one night in November 2007 Aleksandr Kalanda, chief executive officer of Opportunity Bank in Malawi, sat in his office reviewing strategic plans for 2008. The commercial microfinance bank had doubled in size once again in 2007, and now had more than 150,000 customers. In a country where 80 percent of the people live in rural areas with little infrastructure, Opportunity Bank knew that traditional models of microfinance will not bring scale fast enough. The bank had already used technology to develop alternative distribution channels like biometric automated teller machines (ATMs), mobile vans, and kiosks in marketplaces equipped with point-of-sale (POS) devices. The second section looks at the options available to a Microfinance Institution (MFI) if it is in a country with an existing m-banking infrastructure. Finally, the third section of this paper addresses questions that MFIs may have about m-banking, what are the actual benefits for an MFI and its customers? This section explores three key questions: can m-banking help MFIs serve existing customers better? Can m-banking help MFIs reach new customer segments? And can m-banking reduce costs for MFIs and for customers? In the coming years, m-banking could very well revolutionize the way people manage their money in developing countries across the world as it has begun to do in Kenya. Many MFIs have spent decades training and equipping their customers to use financial services like savings and credit.
Attitudinal and Behavioural Determinants Influencing Decision Makers When Adopting Integration Technologies in Local Government

Over the last few years, the advent of innovative or revolutionary integration technologies has influenced pivotal decisions within top management to strategically transform Local Government Authorities (LGAs). These technologies may represent a huge cost for adopting LGAs, but may also offer the chance to achieve competitive advantage through superior service delivery. With the emergence of electronic Government (e-Government), LGAs are turning to integration technologies to fully automate and e-enable their business processes and integrate their IT infrastructures. While prior research on the adoption of integration technologies in the private and public domain has considered several determinants (e.g. benefits, barriers, costs), little attention has been given to investigate the attitudinal and behavioural determinants influencing top management's decision making process for the adoption of integration technologies in LGAs. Notwithstanding, the implications of this research have yet to be assessed, leaving scope for timeliness and novel research. Therefore, it is of high importance to investigate this area within LGAs and contribute to the area of strategic decision making by examining attitudinal and behavioural determinants of top management in relation to integration technologies adoption.
Traumatic Brain Injury and Driver Safety: A Systematic Review

Traumatic brain injuries (TBI) can lead to impairments in cognitive, physical, and psychosocial functions, which may ultimately affect an individual’s ability to drive. A systematic review was conducted to: 1) assess the impact of TBI on crash risk/driving performance; 2) determine what factors associated with TBI are predictive of increased crash risk/poor driving performance; and 3) determine if there is a likelihood of future seizure among individuals with a TBI who did not experience a seizure at the time of the injury. Results indicated that: 1) The available evidence is insufficient to determine whether crash risk is elevated for drivers with TBI compared to uninjured controls (Summary RR=1.32; 95% CI=0.77-2.25). However, driving performance was significantly impaired among individuals with TBI compared to uninjured controls (Strength of Evidence: Moderate); 2) Cognitive function measured by certain neuropsychological tests may predict the outcome of driving performance measured by a road test for patients with TBI. (Strength of Evidence: Moderate); and 3) Individuals with TBI who have not experienced a seizure within the first week post-injury still have a significant likelihood of experiencing late seizure(s). Frequencies of late seizures ranged from 1% to 25% during follow-up periods ranging from 1 to 11 years (Strength of Evidence: Moderate). The highest rate of late seizures (25%) was associated primarily with penetrating missile TBIs (Strength of Evidence: Minimally Acceptable [32% vs. 5%]). These findings have potential implications for regulatory agencies with responsibility for road safety.
Kinetics of Inhibition of HIV Type 1 Reverse Transcriptase-Bearing NRTI-associated Mutations by Apricitabine Triphosphate

We wished to investigate the effects of various mutations in HIV-1 reverse transcriptase (RT) on biochemical inhibition by the active form of a novel nucleoside termed apricitabine. Accordingly, we studied the efficiency of chain-termination mediated by apricitabine triphosphate (TP) in cell-free assays that used either recombinant wild-type or mutated RTs. We also performed steady-state-kinetics and primer-unblocking assays. Subtype C RTs were also analysed. The results showed that the K65R mutation in RT caused reductions in the efficiency of chain-termination of apricitabine-TP by increasing its Ki. However, K65R did not affect rates of primer unblocking for apricitabine-TP. No significant differences were found between subtype C and subtype B RTs with regard to any of the parameters studied. Other mutations such as M184V, L74V and K103N had no effect on the efficiency of chain termination by apricitabine-TP. Thus, the mechanism of reduced susceptibility to apricitabine of viruses containing K65R in RT seems to be mediated exclusively through a reduction in binding or incorporation of apricitabine-TP. Unlike some other nucleoside analogues, increased excision of incorporated apricitabine does not seem to be a cause of resistance to apricitabine.
Personality influences the neural responses to viewing facial expressions of emotion

Cognitive research has long been aware of the relationship between individual differences in personality and performance on behavioural tasks. However, within the field of cognitive neuroscience, the way in which such differences manifest at a neural level has received relatively little attention. We review recent research addressing the relationship between personality traits and the neural response to viewing facial signals of emotion. In one section, we discuss work demonstrating the relationship between anxiety and the amygdala response to facial signals of threat. A second section considers research showing that individual differences in reward drive (behavioural activation system), a trait linked to aggression, influence the neural responsivity and connectivity between brain regions implicated in aggression when viewing facial signals of anger. Finally, we address recent criticisms of the correlational approach to fMRI analyses and conclude that when used appropriately, analyses examining the relationship between personality and brain activity provide a useful tool for understanding the neural basis of facial expression processing and emotion processing in general.
Globalization and Firms' Financing Choices: Evidence from Emerging Economies

The authors investigate whether integration with global markets affects the financing choices of firms from East Asia and Latin America. Using firm-level data for the 1980s and 1990s, they study how leverage ratios, the structure of debt maturity, and sources of financing change when economies are liberalized and when firms gain access to international equity and bond markets. The evidence shows that integration with world financial markets has uneven effects. On the one hand, debt maturity for the average firm shortens when countries undertake financial liberalization. On the other hand, domestic firms that actually participate in international markets, get better financing opportunities, and extend their debt maturity. Moreover, firms in economies with deeper domestic financial systems are affected less by financial liberalization. Finally, they show that leverage ratios increase during times of crisis. In an appendix, they analyze the previously unstudied case of Argentina, which experienced sharp financial liberalization, and was hit hard by all recent global crises.
A study of vocabulary learning strategies for form three students in an English-medium-instruction secondary school

Learning a second language involves the manipulation of four main skills: reading, writing, listening and speaking. One crucial factor in all four skills that underlies the success of second language acquisition is the amount of vocabulary one possesses. Despite the importance of vocabulary and the fact that vocabulary forms the biggest part of the meaning of any language, it is also the biggest problem for most learners. In view of the above situation, a study was carried out to investigate the students’ perceptions and their actual use of strategies. As different learning tasks require different strategies, it is worthwhile looking at how learners learn vocabulary and the strategies they use to discover and retain word meaning. The research involved 200 Form Three students and 20 high achievers in the same form who studied in an EMI secondary school. Data was collected from a vocabulary learning strategies questionnaire, think-aloud vocabulary tasks and semi-structured interviews. Results of this study showed that the students in general favoured strategies focusing on contextual guessing when they encountered new words. Some reported that dictionary strategies were used to confirm guess and prior knowledge including word features, context and world knowledge would lead to successful guessing. Furthermore, the students in the study tended to study word form to consolidate new words and enhance retention but most of them did not systematically keep track of their learning or initiate learning outside class time. Finally, it was found that the high achievers used similar learning strategies as their counterparts but they were more effective in manipulating the