Miracle-dz/UniFAR-FTUs huggingface dataset:
Are virtual channels the bottleneck of priority-aware wormhole-switched NoC-based many-cores?

Preemptions via virtual channels have been proposed as a means to introduce the notion of priorities and real-time concepts in wormhole-switched NoC-based architectures. This work presents a holistic approach, which utilises a novel three-staged mapping method in order to assess what should be the physical characteristics of the platform (and its interconnect), such that real-time guarantees can be provided, assuming a given workload. We estimate the "gap" between platform characteristics required for the real-time analysis and those of currently available many-core platforms and propose to employ the existing feature of many-core platforms in order to significantly reduce this gap. The experiments demonstrate that virtual channels, an essential prerequisite for the real-time analysis, are <u>not</u> the bottle-neck. The approach presented in this paper can help system designers to select/design the most suitable platform for a given workload, such that all temporal constraints are met and over-dimensioning is avoided.
Experimental and analytical investigation of steel beams rehabilitated using GFRP sheets

【Aging and deterioration of existing steel structures necessitate the development of simple and efficient rehabilitation techniques. The current study investigates a methodology to enhance the flexural capacity of steel beams by bonding Glass Fibre Reinforced Plastic (GFRP) sheets to their flanges. A heavy duty adhesive, tested in a previous study is used to bond the steel and the GFRP sheet. In addition to its ease of application, the GFRP sheet provides a protective layer that prevents future corrosion of the steel section. The study reports the results of bending tests conducted on a W-shaped steel beam before and after rehabilitation using GFRP sheets. Enhancement in the moment capacity of the beam due to bonding GFRP sheet is determined from the test results. A closed form analytical model that can predict the yield moment as well as the stresses induced in the adhesive and the GFRP sheets of rehabilitated steel beam is developed. A detailed finite element analysis for the tested specimens is also conducted in this paper. The steel web and flanges as well as the GFRP sheets are simulated using three-dimensional brick elements. The shear and peel stiffness of the adhesive are modeled as equivalent linear spring systems. The analytical and experimental results indicate that a significant enhancement in the ultimate capacity of the steel beam is achieved using the proposed technique. The finite element analysis is employed to describe in detail the profile of stresses and strains that develop in the rehabilitated steel beam. 】
Urban air pollution, and asthma and COPD hospital emergency room visits

Background: There is little previous information of the effects of size fractioned particulate air pollution and source specific fine particles (PM2.5; <2.5 μm) on asthma and chronic obstructive pulmonary disease (COPD) among children, adults and the elderly. Objectives: To determine the effects of daily variation in levels of different particle size fractions and gaseous pollutants on asthma and COPD by age group. Methods: Levels of particulate air pollution, NO2 and CO were measured from 1998 to 2004 at central outdoor monitoring sites in Helsinki, Finland. Associations between daily pollution levels and hospital emergency room visits were evaluated for asthma (ICD10: J45+J46) in children <15 years old, and for asthma and COPD (ICD10: J41+J44) in adults (15–64 years) and the elderly (⩾65 years). Results: Three to 5 day lagged increases in asthma visits were found among children in association with nucleation (<0.03 μm), Aitken (0.03–0.1 μm) and accumulation (0.1–0.29 μm) mode particles, gaseous pollutants and traffic related PM2.5 (7.8% (95% CI 3.5 to 12.3) for 1.1 μg/m3 increase in traffic related PM2.5 at lag 4). Pooled asthma–COPD visits among the elderly were associated with lag 0 of PM2.5, coarse particles, gaseous pollutants and long range transported and traffic related PM2.5 (3.9% (95% CI 0.28 to 7.7) at lag 0). Only accumulation mode and coarse particles were associated with asthma and COPD among adults. Conclusions: Among children, traffic related PM2.5 had delayed effects, whereas among the elderly, several types of particles had effects that were more immediate. These findings suggest that the mechanisms of the respiratory effects of air pollution, and responsible pollutants, differ by age group.
Advances in Brief b-Catenin Mutations Are Specific for Colorectal Carcinomas with Microsatellite Instability but Occur in Endometrial Carcinomas Irrespective of Mutator Pathway 1

Some colorectal tumors with wild-typeadenomatous polyposis coli gene have activating mutations in b-catenin (encoded byCTNNB1) that result in decreased phosphorylation by GSK-3b and increased signaling through the Tcf/Lef transcription factors. To investigate the relationship between CTNNB1 mutations and underlying pathways of genomic instability, we examined 80 colorectal cancers stratified by the presence or absence of microsatellite instability (MSI). CTNNB1 mutations were identified in 13 (25%) of 53 cancers with high frequency MSI (MSI-H), including 12 point mutations at exon 3 phosphorylation sites (codons 41 and 45) and one deletion of the entire exon 3 degradation box. NoCTNNB1mutations were identified in 27 microsatellite stable or low frequency MSI (MSI-L) colorectal cancers (P< 0.01). In contrast,CTNNB1 mutations were identified in 3 of 9 (33%) MSI-H and 10 of 20 (50%) MSS/MSI-L endometrial carcinomas, suggesting a more generalized involvement in these tumors. Only six (46%) of the endometrial carcinoma CTNNB1 mutations occurred at residues directly phosphorylated by GSK-3b, and only one of these was at either codon 41 or 45. All point mutations in MSI-H cancers were transitions, whereas 64% of those in MSS/MSI-L cancers were transversions (P< 0.01). The differences in the mutation profiles suggest that there may be molecular fingerprints of CTNNB1 mutations, determined by biological factors related to both tumor type and underlying pathways of genomic instability.
Shear Strength of Fiber-Reinforced Polymer Reinforced Concrete Beams Subject to Unsymmetric Loading

This study is concerned with the determination of the effects of shear span-to-depth ratio (a/d) and beam depth, or size, on the concrete contribution to the shear resistance of beams longitudinally reinforced with carbon fiber-reinforced polymer (CFRP) bars. One of the distinguishing features of the study is the unsymmetrical nature of the applied load, which creates two distinct a/d ratios in the same beam and allows the effect of the a/d ratio on shear strength to be clearly seen. Six simply supported large size CFRP reinforced concrete beams without shear reinforcement were tested, each under a single concentrated load. The test variables were the a/d ratio, varying from 1.0–11.5, and the beam depth varying from 200–500 mm. All the beams failed in shear, but the failure load and location for some of these beams could not be predicted by the shear design recommendations of American Concrete Institute (ACI) Committee 440. The reason is that these recommendations do not account for the effects of a/d and beam size on shear strength. Suggestions are made for the inclusion of these parameters in the shear design equations.
Using the dog genome to find single nucleotide polymorphisms in red foxes and other distantly related members of the Canidae

Single nucleotide polymorphisms (SNP) are the ideal marker for characterizing genomic variation but can be difficult to find in nonmodel species. We explored the usefulness of the dog genome for finding SNPs in distantly related nonmodel canids and evaluated so‐ascertained SNPs. Using 40 primer pairs designed from randomly selected bacterial artificial chromosome clones from the dog genome, we successfully sequenced 80–88% of loci in a coyote (Canis latrans), grey fox (Urocyon cinereoargenteus), and red fox (Vulpes vulpes), which compared favourably to a 60% success rate for each species using 10 primer pairs conserved across mammals. Loci were minimally heterogeneous with respect to SNP density, which was similar, overall, in a discovery panel of nine red foxes to that previously reported for a panel of eight wolves (Canis lupus). Additionally, individual heterozygosity was similar across the three canids in this study. However, the proportion of SNP sites shared with the dog decreased with phylogenetic divergence, with no SNPs shared between red foxes and dogs. Density of interspecific SNPs increased approximately linearly with divergence time between species. Using red foxes from three populations, we estimated FST based on each of 42 SNPs and 14 microsatellites and simulated null distributions conditioned on each marker type. Relative to SNPs, microsatellites systematically underestimated FST and produced biased null distributions, indicating that SNPs are superior markers for these functions. By reconstituting the frequency spectrum of SNPs discovered in nine red foxes, we discovered an estimated 77–89% of all SNPs (within the region screened) present in North American red foxes. In sum, these findings indicate that information from the dog genome enables easy ascertainment of random and gene‐linked SNPs throughout the Canidae and illustrate the value of SNPs in ecological and evolutionary genetics.
A Stereo Matching Paradigm Based on the Walsh Transformation

Describes a new feature-based stereo matching technique which exploits the Walsh transformation. The established matching strategy adopts and integrates the fundamental steps of the stereo vision problem: (a) detecting and locating feature points, (b) searching for potential matches, (c) validating a match through a global consistency check, and (d) determining the disparity of the matched feature points. The unique representation of stereo images into Walsh-based attributes unites the aforementioned steps into an integrated process which yields accurate disparity extraction. It is shown that the first and second Walsh attributes are used as operators approximating the first and second derivatives for the extraction and localization of feature points. The complete set of these attributes are then used as matching primitives contributing equally to the decision-making process and providing relevant information on both the characterization of a potential match and its validation through a consistency check. Computer results using images of varying complexities prove the soundness and the relatively fast processing time of this stereo matching technique. >
Trials of Lithium, Chlorpromazine and Amitriptyline in Schizoaffective Patients

Summary Two drug trials in schizoaffective patients are reported. Nineteen ‘schizomanic’ patients were treated for one month, on a double blind basis, with chlorpromazine or lithium and 41 ‘schizodepressive’ patients with amitriptyline, chlorpromazine or both. In the schizodepressive patients there was a trend to a better response to chlorpromazine, but drug response generally was poor, only 20 per cent of patients recovering within the month. In the schizomanic patients lithium seemed as effective as chlorpromazine, which supports the view that these patients were suffering from a variant of mania.
International Conference on Information Systems ( ICIS ) 1-1-2009 Extracting Value from ERP Investments : A Closer Look at the Integration Process

When managers consider making an investment in Enterprise Resource Planning (ERP), as with any other investment, a major concern is whether this investment will add value to their organization. This paper suggests that performance differences across firms investing in similar ERP systems can be attributed to the way the technology is integrated with the actual IT infrastructure and business processes of the firm. More precisely, it is argued that depending on manager’s perceived gap between the ERP system and actual business processes and their level of alertness to opportunities, four value creation integration processes, namely the imitative, incremental, innovative, and serendipitous, can be identified. This paper describes these four processes and validates them through six case studies. Understandings of the process to integrate ERP investments with existing business processes and IT infrastructure should helps explain how and why firms investing in similar ERP may have different outcomes.
Impact of Size of the Tumour, Persistence of Estrogen Receptors, Progesterone Receptors, HER2Neu Receptors and Ki67 Values on Positivity of Axillary Lymph Nodes in Patients with Early Breast Cancer with Clinically Negative Axillary Examination

AIM: The study aimed to identify factors that influence the positivity of axillary lymph nodes in patients with early breast cancer and clinically negative axillary lymph nodes, who were subjected for modified radical mastectomy and axillary lymphadenectomy. MATERIAL AND METHODS: This study included 81 surgically treated, early breast cancer patients during the period from 08-2015 to 05-2017. All the cases have been analysed by standard histological analysis including macroscopic and microscopic examination by routine H&E staining. For determination of molecular receptors, immunostaining by PT LINK immunoperoxidase has been done for HER2neu, ER, PR, p53 and Ki67. RESULTS: Patients age ranged between 31-73 years, an average of 56.86 years. The mean size of a primary tumour in the surgically treated patient was 20.33 ± 6.0 mm. Axillary dissection revealed from 5 to 32 lymph nodes, with an average of 14. Metastases have been found in 1 to 7 lymph nodes, with an average 0.7. Only 26 (32.1%) of the patients showed metastases in the axillary lymph nodes. The univariant regression analysis showed that the size of a tumour and presence of HER2neu receptors on cancer cells influence the positivity of the axillary lymph nodes. The presence of the estrogen receptors, progesterone receptors have no influence on the positivity for metastatic deposits of lymph nodes. Multivariant model and logistic regression analysis as significant independent factors or predictors of positivity of the axillary lymph nodes are influenced by the tumour size only. CONCLUSION: Our study showed that the metastatic involvement of the axillary lymph nodes is mainly influenced by the size of a tumour and presence of HER2neu receptors in the univariant analysis. This point to the important influence of positivity of the axillary lymph nodes but, in multi-variant regressive analysis the lymph node status correlates with the tumour size only.
The effects of up to 240 days of tacrolimus therapy on the gingival tissues of rats--a morphological evaluation.

BACKGROUND Tacrolimus, an immunosuppressive drug used in organ transplantation, has been reported not to induce gingival overgrowth. However, prevalence studies are limited, and the methods used for assessing gingival overgrowth varies among studies. OBJECTIVE The purpose of this study was to evaluate the effects of up to 240 days of tacrolimus therapy on gingival tissues of rats. MATERIALS AND METHODS Rats were treated for 60, 120, 180 and 240 days with daily subcutaneous injections of 1 mg/kg body weight of tacrolimus. After histological processing, the oral and connective tissue, volume densities of fibroblasts (Vf), collagen fibers (Vcf) and other structures (Vo) were assessed in the region of the lower first molar. RESULTS After 60 and 120 days of treatment with tacrolimus, gingival overgrowth was not observed. The gingival epithelium, connective tissue, as well as the values for Vf, Vcf, and Vo were similar to those of the control rats (P>0.05). After 180 and 240 days of the treatment, gingival overgrowth was associated with a significant increase in the gingival epithelium and connective tissue as well as an increase in the Vf and Vcf (P<0.05). CONCLUSIONS Within the limits of the experimental study, it may be concluded that the deleterious side effects of tacrolimus on the gingival tissues of rats may be time-related.
Recent Developments in the Endoscopic Treatment of Patients with Peptic Ulcer Bleeding

Peptic ulcer bleeding is an internal medical emergency. Endoscopic hemostasis has been shown to improve the survival rate of patients with peptic ulcer bleeding. Although the established hemostatic modalities, including injection, thermal therapy, and mechanical therapy, are effective in controlling peptic ulcer bleeding, hemostasis can be difficult to achieve in some cases. As a result, recent, new endoscopic hemostatic modalities, including over-the-scope clips, topical hemostatic sprays, and endoscopic ultrasonography-guided angiotherapy, have been developed.
Analysis on Dynamic Lubrication Characteristics of Gas Film in Hard Disk System

The dynamic response of the slider to external interference is analyzed through solving eqations simultaneously of the momentum equations and the time-dependent modified Reynolds equation based on the FK-Boltzmann modified model. Analysis software of autonomous copyright was produced, and the number of the copyright is 2009SR039126. Using this software, the dynamic response curves of the slder under different shocks were obtained, and the numerical results show that under an external motivation the significant vibration is produced. but the slider is capable of returning to the equilibrium position in 0.006ms. Then the lubrication function parameters are calculated, and variable rules of the values also were analyzed. The results shows the oscillation of slider in up-and-down direction have a larger effect on the film lubrication function, yet in the rolling direction the influence is the smallest. Consequently, the fluctuation in up-and-down direction is the main factor of affecting the dynamic lubrication function.
Scratch2 Prevents Cell Cycle Re-Entry by Repressing miR-25 in Postmitotic Primary Neurons

During the development of the nervous system the regulation of cell cycle, differentiation, and survival is tightly interlinked. Newly generated neurons must keep cell cycle components under strict control, as cell cycle re-entry leads to neuronal degeneration and death. However, despite their relevance, the mechanisms controlling this process remain largely unexplored. Here we show that Scratch2 is involved in the control of the cell cycle in neurons in the developing spinal cord of the zebrafish embryo. scratch2 knockdown induces postmitotic neurons to re-enter mitosis. Scratch2 prevents cell cycle re-entry by maintaining high levels of the cycle inhibitor p57 through the downregulation of miR-25. Thus, Scratch2 appears to safeguard the homeostasis of postmitotic primary neurons by preventing cell cycle re-entry.
The Pitfalls of Transgenic Selection and New Roles of AtHXK1: A High Level of AtHXK1 Expression Uncouples Hexokinase1-Dependent Sugar Signaling from Exogenous Sugar1[W]

Arabidopsis ( Arabidopsis thaliana ) hexokinase ( AtHXK1 ) encodes a dual-function enzyme that mediates sugar sensing in addition to its involvement in hexose phosphorylation activity, thereby coordinating sugar availability with plant physiology and development ([Moore et al., 2003][1]; [Rolland et
DoOP: Databases of Orthologous Promoters, collections of clusters of orthologous upstream sequences from chordates and plants

DoOP (http://doop.abc.hu/) is a database of eukaryotic promoter sequences (upstream regions) aiming to facilitate the recognition of regulatory sites conserved between species. The annotated first exons of human and Arabidopsis thaliana genes were used as queries in BLAST searches to collect the most closely related orthologous first exon sequences from Chordata and Viridiplantae species. Up to 3000 bp DNA segments upstream from these first exons constitute the clusters in the chordate and plant sections of the Database of Orthologous Promoters. Release 1.0 of DoOP contains 21 061 chordate clusters from 284 different species and 7548 plant clusters from 269 different species. The database can be used to find and retrieve promoter sequences of a given gene from various species and it is also suitable to see the most trivial conserved sequence blocks in the orthologous upstream regions. Users can search DoOP with either sequence or text (annotation) to find promoter clusters of various genes. In addition to the sequence data, the positions of the conserved sequence blocks derived from multiple alignments, the positions of repetitive elements and the positions of transcription start sites known from the Eukaryotic Promoter Database (EPD) can be viewed graphically.
Occlusal Factors associated with Temporomandibular Disorder based on a Prospective Cohort Study of Young Adults

In this prospective cohort study, mandibular movement analysis was conducted together with clinical examinations to determine the intrinsic occlusal factors that might contribute to the development of TMD. Since mandibular movement analysis has never been conducted previously in this type of cohort study, our results highlight the important implications of occlusal factors potentially associated with TMD. Abstract Purpose: To determine the relationship between temporomandibular disorders (TMD) and the occlusal contact pattern, we conducted occlusal analysis in a prospective cohort study. Methods: One hundred forty-six volunteers consisting of 98 males and 48 females with a mean age of 20.0±1.9 years selected from the dental students of Iwate Medical University were enrolled for the study. All the subjects were asked to ﬁll out a self-adminis-tered questionnaire to screen their general and oral health conditions, and then clinical examination, including evaluation of the occlusal contact pattern, was conducted during the first year. A second clinical examination was repeated 2.5 years later to ascertain the incidence of symptoms of TMD. The natural course of TMD symptoms in the 128 subjects were as follows: group, group, remission group, and continuation group. lateral mandibular types: ④ non-working side molar guided occlusion (NM; n=4), and ⑤ incisal guided occlusion (IG; n=5). Results: In the second examination, 18 out of the 84 subjects (21.4%) who showed no symptoms at the time of enrolment into the study reported TMJ click and/or pain. Of the total, 23, 11, 1, and 1 subjects with symptoms of temporomandibular joint origin were classiﬁed as having the CG, WM, NM, and BG pattern of occlusal contact, respectively. With CG as the standard, the relative risk of TMD in subjects shown the WM pattern was 2.79 (95%CI: 1.16 – 6.70). Conclusion: Since the group showing the working side molar guided occlusion pattern showed a high risk of future development of TMJ click and/or pain, lateral excursion guidance may be a contributing factor for the development of TMD.