Miracle-dz/UniFAR-FTUs huggingface dataset:
Crowding norms at frontcountry sites: A visual approach to setting standards of quality

Indicators and standards of quality have emerged as key variables in defining and managing carrying capacity. Moreover, normative theory has been found useful when applied to the difficult task of setting standards of quality. However, the traditional numerical approach to measuring crowding and related norms has several potential shortcomings when applied to relatively high‐use areas such as frontcountry attraction sites. This study applies a visual approach to measuring crowding norms in addition to the traditional numerical approach. The study is focused on Delicate Arch, a primary visitor attraction in Arches National Park, Utah. Image capture technology was used to develop a series of 16 photographs illustrating a range of people at one time at Delicate Arch. A random sample of 473 visitors was asked to rate the acceptability of each photograph as part of a survey conducted in the summer and fall of 1993. A strong relationship was found between the number of people in the photographs and acceptabilit.
A New Method for Node Fault Detection in Wireless Sensor Networks

Wireless sensor networks (WSNs) are an important tool for monitoring distributed remote environments. As one of the key technologies involved in WSNs, node fault detection is indispensable in most WSN applications. It is well known that the distributed fault detection (DFD) scheme checks out the failed nodes by exchanging data and mutually testing among neighbor nodes in this network. , but the fault detection accuracy of a DFD scheme would decrease rapidly when the number of neighbor nodes to be diagnosed is small and the node's failure ratio is high. In this paper, an improved DFD scheme is proposed by defining new detection criteria. Simulation results demonstrate that the improved DFD scheme performs well in the above situation and can increase the fault detection accuracy greatly.
Rearrangements of 2.5 Kilobases of Noncoding DNA from the Drosophila even-skipped Locus Define Predictive Rules of Genomic cis-Regulatory Logic

Rearrangements of about 2.5 kilobases of regulatory DNA located 5′ of the transcription start site of the Drosophila even-skipped locus generate large-scale changes in the expression of even-skipped stripes 2, 3, and 7. The most radical effects are generated by juxtaposing the minimal stripe enhancers MSE2 and MSE3 for stripes 2 and 3 with and without small “spacer” segments less than 360 bp in length. We placed these fusion constructs in a targeted transformation site and obtained quantitative expression data for these transformants together with their controlling transcription factors at cellular resolution. These data demonstrated that the rearrangements can alter expression levels in stripe 2 and the 2–3 interstripe by a factor of more than 10. We reasoned that this behavior would place tight constraints on possible rules of genomic cis-regulatory logic. To find these constraints, we confronted our new expression data together with previously obtained data on other constructs with a computational model. The model contained representations of thermodynamic protein–DNA interactions including steric interference and cooperative binding, short-range repression, direct repression, activation, and coactivation. The model was highly constrained by the training data, which it described within the limits of experimental error. The model, so constrained, was able to correctly predict expression patterns driven by enhancers for other Drosophila genes; even-skipped enhancers not included in the training set; stripe 2, 3, and 7 enhancers from various Drosophilid and Sepsid species; and long segments of even-skipped regulatory DNA that contain multiple enhancers. The model further demonstrated that elevated expression driven by a fusion of MSE2 and MSE3 was a consequence of the recruitment of a portion of MSE3 to become a functional component of MSE2, demonstrating that cis-regulatory “elements” are not elementary objects.
Additive Effect of Stress and Drug Cues on Reinstatement of Ethanol Seeking: Exacerbation by History of Dependence and Role of Concurrent Activation of Corticotropin-Releasing Factor and Opioid Mechanisms

Stress and exposure to drug-related environmental stimuli have been implicated as critical factors in relapse to drug use. What has received little attention, however, is the significance of interactions between these factors for motivating drug-seeking behavior. To address this issue, a reinstatement model of relapse was used. Footshock stress and response-contingent presentation of an ethanol-associated light cue, acting as a conditioned stimulus (CS), effectively reinstated extinguished responding at a previously active, drug-paired lever in male Wistar rats. When response-contingent availability of the ethanol CS was preceded by footshock, additive effects of these stimuli on responding were observed. Both the individual and interactive effects of footshock and the CS were significantly greater in previously ethanol-dependent than in nondependent rats. Responding induced by the ethanol CS was selectively reversed by the nonselective opiate antagonist naltrexone, whereas the effects of footshock were selectively reversed by the corticotropin-releasing factor (CRF) antagonist d-Phe-CRF12–41. However, both agents only partially reversed the enhanced drug-seeking response produced by the interactive effects of stress and the ethanol CS; full reversal required coadministration of d-Phe-CRF and naltrexone. The results document that stress and drug-related environmental stimuli interact to augment the resumption of drug seeking after extinction and suggest that this effect results from concurrent activation of opioid and CRF transmission.
Low natural killer activity and central nervous system disease as a high‐risk prognostic indicator in young patients with hemophagocytic lymphohistiocytosis

Familial hemophagocytic lymphohistiocytosis HLH (FHL) is fatal, unless patients are rescued with hematopoietic stem cell transplantation (SCT). Although the molecular identification of FHL now is possible at least in part from perforin gene study, many cases escape detection or never are tested due to the lack of specific hallmarks, making diagnosis difficult. To the authors' knowledge, it remains to be determined whether persistently low natural killer cell (NK) activity and a high incidence of central nervous system (CNS) disease increase the probability of FHL.
Bireysel Yenilikçilik Ölçeği (BYÖ): Türkçeye Uyarlama, Geçerlik Ve Güvenirlik Çalışması

Bu calismanin amaci 1977 yilinda H. Thomas Hurt, Katherine Joseph ve Chester. D. Cook tarafindangelistirilen ve gecerligi ve guvenirligi bircok arastirmaci tarafindan farkli orneklemler uzerinde test edilerek kabul edilen“Bireysel Yenilikcilik Olcegi”nin Turkceye uyarlanmasinin gerceklestirilmesidir. 343 universite ogrencisi uzerinde gecerlikve guvenirlik calismasi gerceklestirilen 20 maddeli Turkce olcegin dort faktorlu bir yapi sergiledigi, faktor yapilarinin gecerlioldugu, geneline iliskin ic tutarlik katsayisinin 0.82 oldugu, test-tekrar test guvenirliginin 0.87 oldugu saptanmistir.Uyarlanan olcegin yenilikcilik ve yenilikcilik konusu ile bagintili Turkce akademik calismalarda kullanilabilir oldugusoylenebilir
Human NLRP3 inflammasome senses multiple types of bacterial RNAs

Significance The innate immune system has evolved to protect the host from potential pathogens. The nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3 (NLRP3) inflammasome is one of the platforms that can sense pathogenic bacteria, which can cause fatal bacterial infections. Here we show that all three types of bacteria-derived RNA—mRNA, tRNA, and rRNAs—as well as synthetic 20-guanosine ssRNA, are capable of activating the NLRP3 inflammasome and inducing human macrophages to secrete inflammatory cytokines. Interestingly, only bacterial mRNA is able to activate the murine Nlrp3 inflammasome. Therefore human macrophages may have evolved in a unique fashion, adapting to the bacterial environment. This study could provide important clues for developing efficient medicines for bacterial infections and various immunotherapies such as anticancer vaccines. Inflammasomes are multiprotein platforms that activate caspase-1, which leads to the processing and secretion of the proinflammatory cytokines IL-1β and IL-18. Previous studies demonstrated that bacterial RNAs activate the nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3 (NLRP3) inflammasome in both human and murine macrophages. Interestingly, only mRNA, but neither tRNA nor rRNAs, derived from bacteria could activate the murine Nlrp3 inflammasome. Here, we report that all three types of bacterially derived RNA (mRNA, tRNA, and rRNAs) were capable of activating the NLRP3 inflammasome in human macrophages. Bacterial RNA’s 5′-end triphosphate moieties, secondary structure, and double-stranded structure were dispensable; small fragments of bacterial RNA were sufficient to activate the inflammasome. In addition, we also found that 20-guanosine ssRNA can activate the NLRP3 inflammasome in human macrophages but not in murine macrophages. Therefore, human and murine macrophages may have evolved to recognize bacterial cytosolic RNA differently during bacterial infections.
Morphological Study of the Entorhinal Cortex, Hippocampal Formation, and Basal Ganglia in Rett Syndrome Patients

Entorhinal cortex (EC), fascia dentata (FD), hippocampus (HP), and basal ganglia (BG) were studied in Rett syndrome (RS) cases and compared with control brains and an autism case. Kluver-Barrera and Golgi methods were used. In RS most of the areas of EC, HP, and FD showed severe cell hypochromia. In the EC all cells of layer II and most in layer III were in a state of total chromatolysis or were "ghost" cells, but the cells of layers V and VI were preserved and moderately hyperchromic. In FD and HP the majority of the granular cells and cells of CA3 and CA4 fields were severely hypochromic, whereas in the CA1 field most cells were normal or slightly hypercaryochromic. In BG mostly mild or moderate aberration from normal cell structure was observed: in striatum, mild hypercaryochromia of small neurons and more expressive hyperchromia of large neurons were found; and in pallidum, mild or moderate hypercaryochromia to severe hyperchromia in pallidum internum was found. Degeneration of thick myelinated fibers was evident in pallidum. Large striatal and pallidal neurons showed signs of constructive changes in Golgi slices. These data allow the determination of the cause of the main symptoms of RS. The motor disorders, including specific stereotyped movements, could be related to the enhanced activity of BG cells due to their deafferentation from the side of the neocortex and to supposed hyperactivity of the EC-striatal pathway; the mental retardation and epileptic seizures could be due to FD-HP involvement.
Environmental Munihcence; A Theoretical Assessment

Two research limitations pertaining to environmental munificence-organization relationships are examined: (a) overabstraction, which exists when environment is defined too broadly, resulting in inappropriate aggregation of disparate environmental units and (b) conceptual ambiguity, which exists when researchers use different labels to describe similar munificence constructs and similar labels to describe different constructs. These limitations are clarified, and measurement suggestions, along with other research implications, are discussed.
Perfectionism in Anxiety and Depression: Comparisons across Disorders, Relations with Symptom Severity, and Role of Comorbidity

We investigated perfectionism in clinical samples using new measures of maladaptive cognitive-personality dimensions—the Evaluative Concerns Perfectionism Scale (ECPS) and Self-Critical Perfectionism Scale (SCPS), as well as the Frost (FMPS) and the Hewitt and Flett (HMPS) Multidimensional Perfectionism Scales. Outpatients (N = 190) with a principal diagnosis of social anxiety disorder (SAD), panic disorder with or without agoraphobia (PDA), obsessive-compulsive disorder (OCD), or predominantly major depressive disorder were compared to non-psychiatric controls. Patients with depression and SAD had similar or significantly higher scores than the controls, and patients with PDA and/or OCD on many perfectionism measures. OCD patients were also higher than controls and those with PDA on many scales. PDA patients were similar to controls on all but a few measures. The SCPS was the only consistent unique positive predictor of variance on the Depression Anxiety Stress Scale (DASS) in a combined patient group.
The Relation Between School Leadership From a Distributed Perspective and Teachers’ Organizational Commitment

Purpose: In this study the relationship between school leadership and teachers’ organizational commitment is examined by taking into account a distributed leadership perspective. The relation between teachers’ organizational commitment and contextual variables of teachers’ perceptions of the quality and the source of the supportive and supervisory leadership function, participative decision making, and cooperation within the leadership team are examined. Research Design: A survey was set up involving 1,522 teachers from 46 large secondary schools in Flanders (Belgium). Because the data in the present study have an inherent hierarchical structure, that is, teachers are nested into schools, hierarchical linear modeling techniques are applied. Findings: The analyses reveal that 9% of the variance in teachers’ organizational commitment is attributable to differences between schools. Teachers’ organizational commitment is mainly related to quality of the supportive leadership, cooperation within the leadership team, and participative decision making. Who performed the supportive leadership function plays only a marginally significant positive role. The quality of the supervisory leadership function and the role of the leadership team members in this function were not significantly related to teachers’ organizational commitment. Conclusions: The implications of the findings are that to promote teachers’ organizational commitment teachers should feel supported by their leadership team and that this leadership team should be characterized by group cohesion, role clarity, and goal orientedness. Recommendations for further research are provided.
Boll Weevil (Coleoptera: Curculionidae) Survival Through the Seed Cotton Cleaning Process in the Cotton Gin

Abstract There is concern that gins located in boll weevil, Anthonomus grandis grandis Boheman, eradication zones may become points of reintroduction when they process cotton grown in a neighboring infested area. We estimated boll weevil survival through two typical machine sequences used in commercial cotton gins to clean and dry the seed cotton in advance of the gin stand, as well as separately through two incline cylinder cleaners or one or two tower dryers operating at different temperatures. Large numbers of laboratory-reared adult boll weevils were marked with fluorescent powder, fed into the test system, and recovered with the assistance of blacklights. We found no evidence of survival through the seed cotton cleaning systems even when the dryers were not heated, or when passed separately through the two incline cleaners alone. Upper confidence limits (95%) were calculated for the observed zero recoveries based on sample size and the binomial distribution, and these represent the statistical worst-case (i.e., highest) survival potential. Survival through heated tower dryers declined rapidly to zero at higher temperatures, especially when two dryers were running. Although we conclude that the potential for survival of weevils in the seed cotton to the gin stand is zero or close to zero, a small percentage of live weevils was recovered in the green boll/rock trap, which may represent the greatest threat of reintroduction at the gin. Escape of live weevils with the gin trash is also possible, and studies addressing this issue will be presented elsewhere.
Selective attention and cognitive control: dissociating attentional functions through different types of load

Book description: One of the most challenging problems facing cognitive psychology and cognitive neuroscience is to explain how mental processes are voluntarily controlled, allowing the computational resources of the brain to be selected flexibly and deployed to achieve changing goals. The eighteenth of the celebrated international symposia on Attention and Performance focused on this problem, seeking to banish or at least deconstruct the "homunculus": that conveniently intelligent but opaque agent still lurking within many theories, under the guise of a central executive or supervisory attentional system assumed to direct processes that are not "automatic. " The thirty-two contributions discuss evidence from psychological experiments with healthy and brain-damaged subjects, functional imaging, electrophysiology, and computational modeling. Four sections focus on specific forms of control: of visual attention, of perception-action coupling, of task-switching and dual-task performance, and of multistep tasks. The other three sections extend the interdisciplinary approach, with chapters on the neural substrate of control, studies of control disorders, and computational simulations. The progress achieved in fractionating, localizing, and modeling control functions, and in understanding the interaction between stimulus-driven and voluntary control, takes research on control in the mind/brain to a new level of sophistication.
School Climate: Historical Review, Instrument Development, and School Assessment

This study’s purpose is to examine the existing school climate literature in an attempt to constitute its definition from a historical context and to create a valid and reliable student-reported school climate instrument. Five historically common school climate domains and five measurement tools were identified, combined, and previewed by the target audience to determine face validity. The final student sample (N = 2,049) was randomly split into exploratory and confirmatory samples and subjected to factor analytic and structural equation modeling techniques. Factor analysis results confirmed an eight-factor solution (loadings with absolute values > .40). Item factor loadings ranged from . 42 to . 87. Coefficient alphas ranged from . 65 to . 91. Preliminary analyses support the reliability and validity of the instrument. This is the first study to balance historical precedent (what to measure) and modern scale development procedures (e.g., structural equation modeling) into a single attempt to measure school climate. Implications and potential uses are discussed.
DLX3 Mutation in a New Family and Its Phenotypic Variations

Tricho-dento-osseous syndrome (TDO) is an autosomal-dominant disease characterized by curly hair at birth, enamel hypoplasia, taurodontism, and a thick cortical bone. A common DLX3 gene mutation (c.571_574delGGGG) has been identified in multiple families with variable clinical phenotypes. Recently, another DLX3 gene mutation (c.561_562delCT) was reported to cause amelogenesis imperfecta with taurodontism (AIHHT). We identified a Korean family with overlapping phenotypes of TDO and AIHHT. We performed mutational analysis to discover its genetic etiology. The identified mutation was c. 561_562delCT mutation in the DLX3 gene. The enamel was hypomature and hypoplastic. The characteristic taurodontic features were not identified. Increased bone density or thickness could not be revealed by cephalometric, hand-wrist, and panoramic radiographs. Affected individuals reported that their nails were brittle, and they had curly hair at birth. This study clearly showed that the c. 561_562delCT mutation had not only enamel defects, but also other clinical phenotypes resembling those of TDO syndrome.
Single-breath vital capacity high concentration sevoflurane induction in children: with or without nitrous oxide?

BACKGROUND Single-breath vital capacity inhalation induction with high concentration sevoflurane (SBVC-HC) is a rapid and 'needleless' technique, preferred and well tolerated in the cooperative child. The addition of nitrous oxide may speed up induction by its second gas effects. Previous studies done in children looking at the effect of N(2)O on this technique lacked power and showed conflicting results. This study aims to investigate the effect of N(2)O on induction time for SBVC-HC sevoflurane induction in children. METHODS Eighty unpremedicated, ASA I and II children, aged 5-15 yr having elective surgical procedures under general anaesthesia, were recruited and randomized to: Group A: 8% sevoflurane in O(2) 6 litre min(-1), and Group B: 8% sevoflurane in N(2)O 4 litre min(-1) and O(2) 2 litre min(-1). The primary outcome was the time to 'loss of eyelash reflex'. The time to return of 'regular respiration' and 'conjugate gaze' were also noted. RESULTS The difference in the 'time to loss of eyelash reflex' was small but statistically significant. Group B: mean duration 53.6 s, standard deviation (SD) 16.1, compared with Group A: 63.5 s, SD 16.1 (mean difference 9.9, 95% confidence interval 2.5-17.3, P=0.01). Differences in the time to return of 'regular breathing' and 'conjugate gaze' were not statistically significant. Patients receiving N(2)O had less excitatory movements (P=0.007), but incidence of other adverse events was low and did not differ significantly between both groups. More than 94% of children would choose this method of induction again in both groups. CONCLUSIONS We conclude that for SBVC-HC sevoflurane induction in children, the addition of N(2)O resulted in faster loss of consciousness and reduced excitatory movements.
Distribution of protein composition in bread wheat flour mill streams and relationship to breadmaking quality

ABSTRACTWheat protein quantity and composition are important parameters for wheat baking quality. The objective of this study was to use fractionation techniques to separate the proteins of flour mill streams into various protein fractions, to examine the distribution of these protein fractions, and to establish a relationship between protein composition and breadmaking quality. Nine break streams, nine reduction streams, and three patent flours obtained from three samples of Nekota (a hard red winter wheat) were used in this study. A solution of 0.3M NaI + 7.5% 1-propanol was used to separate flour protein into monomeric and polymeric proteins. The protein fractions, including gliadin, albumin+globulin, HMW-GS, and LMW-GS, were precipitated with 0.1M NH4Ac-MeOH or acetone. The fractions were statistically analyzed for their distribution in the mill streams. The quantities of total flour protein and protein fractions in flour were significantly different among mill streams. The ratio of polymeric to monom.