Miracle-dz/UniFAR-FTUs huggingface dataset:
Entropy and mixing for amenable group actions.

For i a countable amenable group consider those actions of i as measurepreserving transformations of a standard probability space, written asfT∞g∞2i acting on (X;F;„). We sayfT∞g∞2i has completely positive entropy (or simply cpe for short) if for any flnite and nontrivial partition P of X the entropy h(T;P) is not zero. Our goal is to demonstrate what is well known for actions of and even d , that actions of completely positive entropy have very strong mixing properties. Let Si be a list of flnite subsets of i. We say the Si spread if any particular ∞6 id belongs to at most flnitely many of the sets SiS i1 i . Theorem 0.1. For fT∞g∞2i an action of i of completely positive entropy and P any flnite partition, for any sequence of flnite sets Siµ i which spread we have
First results on a new PIAA coronagraph testbed at NASA Ames

Direct imaging of extrasolar planets, and Earth-like planets in particular, is an exciting but difficult problem requiring a telescope imaging system with 1010 contrast at separations of 100mas and less. Furthermore, the current NASA science budget may only allow for a small 1-2m space telescope for this task, which puts strong demands on the performance of the imaging instrument. Fortunately, an efficient coronagraph called the Phase Induced Amplitude Apodization (PIAA) coronagraph has been maturing and may enable Earth-like planet imaging for such small telescopes. In this paper, we report on the latest results from a new testbed at NASA Ames focused on testing the PIAA coronagraph. This laboratory facility was built in 2008 and is designed to be flexible, operated in a highly stabilized air environment, and to complement existing efforts at NASA JPL. For our wavefront control we are focusing on using small Micro-Electro- Mechanical-System deformable mirrors (MEMS DMs), which promises to reduce the size of the beam and overall instrument, a consideration that becomes very important for small telescopes. At time of this writing, we are operating a refractive PIAA system and have achieved contrasts of about 1.2x10-7 in a dark zone from 2.0 to 4.8 λ/D (with 6.6x10-8 in selected regions). In this paper, we present these results, describe our methods, present an analysis of current limiting factors, and solutions to overcome them.
Perceptions of Entrepreneurial Behaviour in Botswana

With the high rate of unemployment in Botswana, it has become imperative that the alternative source of employment seen by policy makers and researchers as the panacea to the problem, is entrepreneurship. Although, research has been conducted on entrepreneurship, little has been done on the university students’ perceptions of entrepreneurial behaviour in Botswana. To fill this gap, this paper seeks to investigate university students’ perceptions of various entrepreneurial characteristics, motivators and challenges in Botswana. To achieve this, a sample of 394 undergraduate students of the University of Botswana was targeted. Findings of the current study indicate that students perceived an entrepreneur as an individual who possesses the right managerial skills, take risks, contribute to the economy, utilize available resources optimally, is creative and successful. Although the current study is based on undergraduate students, an investigation of entrepreneurial behaviour that exists among potential entrepreneurs in Botswana is important, since it will enable policy makers and other stakeholders to intensify and channel initiatives to promote self employment. Key words : Botswana, Entrepreneur, Entrepreneurship, motivators, traits
Financial Integration and Growth: A Nonlinear Panel Data Analysis

This paper employs Panel Smooth Transition Models (PSTR) to examine the financial integration and economic growth relationship for a large panel data set consisting of 82 countries and for three subsamples, namely emerging, industrial, and developing countries, for 1970-2010 periods. Unlike linear specifications with interaction terms, PSTR models are flexible enough to endogenously determine how the degree of institutional quality, financial sector development, trade openness, budget deficit, inflation volatility and financial integration can have a role in revealing asymmetries in financial integration-growth nexus. Except developing countries, empirical results strongly indicate nonlinear dynamics and imply that the impact of financial integration on growth is asymmetric depending on the threshold effects of these variables which show great variation not only from variable to variable but also for different country groups. As far as whole set of countries is concerned, our findings imply that countries having developed financial systems, qualified institutions and stable macroeconomic environment seem to be benefiting from financial integration. Moreover, nonlinear threshold effects are more apparent and different for emerging countries compared to the industrial countries. Unlike former economies, higher levels of financial integration and trade openness decrease benefits from financial openness for the industrial countries. Besides, high fiscal deficit has more pronounced negative effect on the growth of the industrialized countries compared to emerging economies and other indicators.
Zidovudine does not affect transplacental transfer or systemic clearance of stavudine (2',3'-didehydro-3'-deoxythymidine) in the pigtailed macaque (Macaca nemestrina)

Stavudine (22 micrograms/min/kg of body weight) was infused alone (via the femoral vein) or simultaneously with zidovudine (66 micrograms/min/kg) to three near-term pregnant macaques. No significant differences were found between the mean steady-state plasma stavudine concentrations in the dam (Cssd) and fetus (Cssf), the stavudine concentration in the amniotic fluid (Cssa), and the ratios Cssf/Cssd and Cssa/Cssf when stavudine was infused alone or in combination with zidovudine. The data obtained indicate that zidovudine administration does not affect the transfer of stavudine across the placenta in Macaca nemestrina.
Offline cursive handwriting recognition system based on hybrid Markov model and neural networks

An offline cursive handwriting recognition system based on hybrid of neural networks (NN) and hidden Markov models (HMM) is described in this paper. Applying SegRec principle, the recognizer does not make hard decision at the character segmentation process. Instead, it delays the character segmentation to the recognition stage by generating a segmentation graph that describes all possible ways to segment a word into letters. To recognize a word, the NN computes the observation probabilities for each segmentation candidates (SCs) in the segmentation graph. Then, using concatenated letter-HMMs, a likelihood is computed for each word in the lexicon by multiplying the probabilities over the best paths through the graph. We present in detail two approaches to train the word recognizer: 1. ) character-level training 2. ) word-level training. The recognition performances of the two systems are discussed.
Hemianopia and Neglect Influence on Straight-Ahead Perception

In spatial neglect, the pathological ipsilesional deviation of the subjective straight ahead (SSA) received both ‘translational’ and ‘rotational’ interpretations. Furthermore, hemianopia per se could also influence straight-ahead (SA) perception. Here, we aimed at disentangling the relative effects of neglect and hemianopia on the SSA by using a method analyzing translation and rotation in parallel. We included patients with a right hemisphere stroke. Ten had neglect and hemianopia, 6 neglect only, 3 hemianopia only, and 12 neither one nor the other. 15 were controls. Participants had to adjust a bar, movable in translation and rotation, SA of the navel, in darkness. Patients with spatial neglect showed systematic rightward translation, greater when hemianoptic. The rotation component appeared more variable and was influenced by the presence of a visual field defect, as most of the patients with hemianopia showed an anticlockwise rotation and most of the patients without hemianopia a clockwise rotation. Non-neglect patients and control subjects demonstrated a fair performance level. In conclusion, both neglect and hemianopia resulted in a translation error of the SSA to the ipsilesional side. In neglect patients, additional hemianopia resulted in a counterclockwise rotation. Furthermore, rotation and translation errors appeared dissociated, suggesting a different coding of these dimensions by the right posterior hemisphere.
Low vitamin B-12 status in confirmed Alzheimer’s disease as revealed by serum holotranscobalamin

Objective: To examine the possible association of holotranscobalamin, the active fraction of serum cobalamin, with Alzheimer’s disease. Methods: 51 patients with pathologically confirmed Alzheimer’s disease and 65 cognitively screened elderly controls were studied. Serum holotranscobalamin was measured by a new solid phase radioimmunoassay. Results: Geometric mean levels showed no significant case–control differences for serum total cobalamin, but lower levels of holotranscobalamin in Alzheimer’s disease (41.1 pmol/l) than in controls (57.1 pmol/l) (p < 0.001). The odds ratio of Alzheimer’s disease was significant for low holotranscobalamin but not for low total cobalamin. Conclusions: Disturbed cobalamin status is common in Alzheimer’s disease and accordingly measurement of holotranscobalamin should be considered in the assessment of cognitively impaired patients.
Advances in Silicon-On-Insulator Cellular Antenna Switch Technology

Silicon-on-insulator technology utilizing very high resistivity handle wafers demonstrates sufficient performance for many cellular handset requirements. Technologies with either thin or thick device layers show promise. Thick-SOI prototype single pole six throw switch (SP6T) P-0.1dB of about 40 dBm and -75 dBc harmonic at 35 dBm output have been demonstrated at 900 MHz. Thin-SOI Ron-Coff product similar to that of pHEMT has been demonstrated experimentally. Obstacles such as distortion caused by Si-SiO2 interfaces remain a fascinating engineering challenge to fully exploit the opportunity.
Gene–gene interactions between HLA‐C, ERAP1, TNFAIP3 and TRAF3IP2 and the risk of psoriasis in the Chinese Han population

N.C. DLOVA H.F . JORDAAN A. SK EN J ANE N. KHOZA A. TOS T I 3 Dermatology Department, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa Division of Dermatology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 33136 Miami, FL U.S.A. E-mail: dlovan@ukzn.ac. za
The Effects of Halothane Pretreatment on Manganese Influx Induced by Muscarinic Stimulation of Airway Smooth Muscle

We hypothesized that halothane inhibits contraction of canine airway smooth muscle in part by depleting sarcoplasmic reticulum (SR) calcium stores, which affects subsequent force and calcium influx.This hypothesis was tested by using the rate of quenching of fura-2 fluorescence by manganese (Mn2+) as an index of calcium influx. When added 10 min before submaximum muscarinic stimulation (with 0.3 micro M acetylcholine [ACh]), halothane (0.60 +/- 0.04 mM [mean +/- SE]) reduced subsequent isometric force and intracellular calcium concentration ([Ca2+]i) measured 10 min after contraction (to 55% +/- 5% and 69% +/- 4% of control, respectively). The Mn2+ influx measured concurrently was significantly increased by halothane (by 57% +/- 22%). Depletion of SR calcium stores by ACh prior to contraction also increased Mn2+ influx (by 46% +/- 6%) but did not affect developed force or increase [Ca2+]i in response to submaximum muscarinic stimulation. Halothane did not affect [Ca2+]i or Mn2+ influx when added prior to maximum stimulation with 100 micro M ACh but significantly reduced developed force. These findings are consistent with the hypothesis that halothane-induced SR depletion prior to contraction stimulates subsequent calcium influx, but they further suggest that halothane-induced SR depletion itself does not contribute significantly to the reduction in contractility produced by halothane in the canine airway smooth muscle. (Anesth Analg 1997;84:1366-71)
Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats

Panus giganteus, a culinary and medicinal mushroom consumed by selected indigenous communities in Malaysia, is currently being considered for large scale cultivation. This study was undertaken to investigate the hepatoprotective effects of P. giganteus against thioacetamide- (TAA-) induced liver injury in Sprague-Dawley rats. The rats were injected intraperitoneally with TAA thrice weekly and were orally administered freeze-dried fruiting bodies of P. giganteus (0.5 or 1 g/kg) daily for two months, while control rats were given vehicle or P. giganteus only. After 60 days, rats administered with P. giganteus showed lower liver body weight ratio, restored levels of serum liver biomarkers and oxidative stress parameters comparable to treatment with the standard drug silymarin. Gross necropsy and histopathological examination further confirmed the hepatoprotective effects of P. giganteus. This is the first report on hepatoprotective effects of P. giganteus. The present study showed that P. giganteus was able to prevent or reduce the severity of TAA-induced liver injury.
Determinants of diet quality

Abstract Background: An unbalanced diet is a main risk factor for several chronic diseases. This paper identifies groups of individuals with an unbalanced diet based on the consumption of nutrients. A characterisation of the groups may help to focus efforts aimed at improving the dietary behaviour of the population. Methods: Using nutritional data of 1763 men and 2267 women participating in the German Nutrition Survey of 1998, we constructed two indices for diet quality that each combines a large amount of nutrients into a single indicator. The impact of sociodemographic and lifestyle characteristics on the diet quality indices was analysed using multiple regression analyses. Results: The results show a considerable variation of diet quality between different groups of individuals. High diet quality in terms of the consumption of vitamins, minerals and trace elements is positively associated with income, education level, age, energy intake, food diversity, sport activity and vegetarianism. On the other hand, a low diet quality as indicated by high intakes of e.g. fat, sugar, alcohol and sodium can be expected when energy intake is high, for individuals of middle age and for pregnant and breast-feeding women. Conclusion: The results of this study help to identify groups of individuals with preferable and non-preferable diet quality. For developing public health strategies, in particular the impact of age on diet quality seems to be interesting. The rising diet quality with increasing age could reflect a changing health consciousness. It could thus be a challenge for health policy to promote a healthy way of living focused especially on young individuals.
Effect of glucocorticoid receptor gene polymorphisms in Guillain‐Barré syndrome

Guillain‐Barré syndrome (GBS) is a postinfectious immune‐mediated polyneuroradiculopathy in which host factors influence disease susceptibility and clinical course. Single‐nucleotide polymorphisms (SNPs) in the glucocorticoid receptor (GR) gene influence the sensitivity to glucocorticoids and are related to both microbial colonization and susceptibility to develop auto‐immune disease. This genetic variation may therefore also influence the chance to develop GBS. In this study, we genotyped 318 GBS patients and 210 control subjects for five known SNPs in the GR gene. We could distinguish six different GR haplotypes of which two carried the BclI polymorphism: haplotype 1, which consists of the minor allele of BclI in combination with the common variant of TthIIII and haplotype 2, which carries the minor allele of BclI as well as the minor allele of TthIIII. The GR haplotypes were not related to susceptibility to develop GBS. Carriers of haplotype 2 had more frequently preceding diarrhea, serum antibodies to GM1 and GD1a, and more severe muscle weakness at entry. Haplotype 1 carriers had a significantly better prognosis. In conclusion, GR haplotypes are not a susceptibility factor for GBS. However, haplotypes carrying the minor allele of the BclI polymorphism were related to the phenotype and outcome of GBS.
Effectiveness of paediatric asthma clinical pathways: a narrative systematic review

Abstract Objective: To evaluate the effectiveness of clinical pathways (CPs) for paediatric asthma on length of hospital stay, additional visits due to asthma exacerbations, hospital cost, manpower and workload required for implementing CPs. Methods: Studies were eligible if they met the following criteria: children (≦18 years) with asthma, hospital or emergency department based, and study designs were (1) randomised controlled trial, (2) controlled clinical trial or (3) controlled before and after study. Two reviewers independently screened references, extracted data and assessed the risk of bias. We resolved disagreement by discussion between authors. Due to an insufficient number of studies and the heterogeneity of interventions and outcomes, we conducted a narrative systematic review with forest plots but did not pool results. Results: About 3155 relevant articles were identified through a literature search, 628 were duplicates removed, 2037 were excluded based on review of titles and abstracts and 117 were excluded because they did not meet inclusion criteria. Seven studies involving 2600 participants met the inclusion criteria. Using asthma CPs may decrease the length of hospital stay; however, CPs did not appear to reduce additional visits due to asthma exacerbations or reduce hospital costs. No eligible studies were found that quantified the manpower and workload for implementing CPs. Conclusions: Current studies suggest CPs may reduce the length of hospital stay, but insufficient evidence is available on total costs or readmissions to justify extensive uptake of asthma CPs in paediatric inpatient care. Higher quality, large randomised controlled trials are required that measure costs and a wider range of outcomes.
Dendritic Cells Restore CD8+ T Cell Reactivity to Autologous HIV-1

ABSTRACT Recall T cell responses to HIV-1 antigens are used as a surrogate for endogenous cellular immune responses generated during infection. Current methods of identifying antigen-specific T cell reactivity in HIV-1 infection use bulk peripheral blood mononuclear cells (PBMC) yet ignore professional antigen-presenting cells (APC) that could reveal otherwise hidden responses. In the present study, peptides representing autologous variants of major histocompatibility complex (MHC) class I-restricted epitopes from HIV-1 Gag and Env were used as antigens in gamma interferon (IFN-γ) enzyme-linked immunosorbent spot (ELISpot) and polyfunctional cytokine assays. Here we show that dendritic cells (DC) enhanced T cell reactivity at all stages of disease progression but specifically restored T cell reactivity after combination antiretroviral therapy (cART) to early infection levels. Type 1 cytokine secretion was also enhanced by DC and was most apparent late post-cART. We additionally show that DC reveal polyfunctional T cell responses after many years of treatment, when potential immunotherapies would be implemented. These data underscore the potential efficacy of DC immunotherapy that aims to awaken a dormant, autologous, HIV-1-specific CD8+ T cell response. IMPORTANCE Assessment of endogenous HIV-1-specific T cell responses is critical for generating immunotherapies for subjects on cART. Current assays ignore the ability of dendritic cells to reveal these responses and may therefore underestimate the breadth and magnitude of T cell reactivity. As DC do not prime new responses in these assays, it can be assumed that the observed responses are not detected without appropriate stimulation. This is important because dogma states that HIV-1 mutates to evade host recognition and that CD8+ cytotoxic T lymphocyte (CTL) failure is due to the inability of T cells to recognize the autologous virus. The results presented here indicate that responses to autologous virus are generated during infection but may need additional stimulation to be effective. Detecting the breadth and magnitude of HIV-1-specific T cell reactivity generated in vivo is of the utmost importance for generating effective DC immunotherapies.
On Kleinberg's Stochastic Discrimination Procedure

A new condition for high accuracy on test sets is given for the method of stochastic discrimination (SD), a pattern recognition method introduced by Kleinberg. This condition provides a simple explanation for the observed good generalization properties and overtraining-resistance. We also show that the method of SD remains valid if the original assumption of uniform distribution on a finite space for resampling is relaxed.
The effect of fasting in Ramadan on the values and interrelations between biochemical, coagulation and hematological factors.

BACKGROUND The possible consequences of the long intermittent fasting schedule during Ramadan (one month of food and water intake limited to night hours, a practice that is followed by the majority of the Muslims worldwide) on certain biochemical constituents or coagulation variables have not been extensively documented. PATIENTS AND METHODS During the month of Ramadan and two months after, we monitored the concentration of different plasma lipoproteins, lipoprotein (a) [Lp(a)], apoproteins A(1) and B, fibrinogen, factor VII activity and some selected hematological factors in 50 healthy subjects who were employees of institutes related to the Isfahan University of Medical Sciences and aged between 30 and 45 years. The effect of fasting in Ramadan on the relationship between biochemical and coagulation variables was also investigated. RESULTS The values of apoprotein B, Lp(a) and low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio were significantly decreased during Ramadan (P<0.05), while total cholesterol (Tot-C), triglycerides (TG), LDL-C, HDL-C and fasting blood glucose did not change during that month. Among coagulation and hematological factors, fibrinogen level and factor VII activity were significantly decreased during the month (P<0.05). Results also indicated a significant positive association between fibrinogen level and Lp(a), factor VII activity and Tot-C, LDL-C, TG and Apo B during Ramadan. CONCLUSION Our findings contribute to a better understanding of previous reports, as the metabolic and coagulation changes that are considered as atherosclerosis risk factors are counterbalanced during Ramadan.