Miracle-dz/UniFAR-FTUs huggingface dataset:
Coseismic and postseismic deformation of the 2011 Tohoku‐Oki earthquake constrained by GRACE gravimetry

Spaceborne gravimetry data from the Gravity Recovery And Climate Experiment (GRACE) are processed using spatio‐spectral Slepian localization analysis enabling the high‐resolution detection of permanent gravity change associated with both coseismic and postseismic deformation resulting from the great 11 March 2011 Mw 9.0 Tohoku‐Oki earthquake. The GRACE observations are then used in a geophysical inversion to estimate a new slip model containing both coseismic slip and after‐slip. The GRACE estimated moment for the total slip, up to the end of July 2011 is estimated as (4.59 ± 0.49) × 1022 N m, equivalent to a composite Mw of 9.07 ± 0.65. If the moment for the Tohoku‐Oki main shock is assumed to be 3.8 × 1022 N m, the contribution from the after‐slip is estimated to be 3.0 × 1021–12.8 × 1021 N m, in good agreement with a postseismic slip model inverted from GPS data. We conclude that GRACE data provide an independent constraint to quantify co‐ and post‐seismic deformation for the Tohoku‐Oki event.
DNA-Methylation Patterns in Trisomy 21 Using Cells from Monozygotic Twins

DNA methylation is essential in mammalian development. We have hypothesized that methylation differences induced by trisomy 21 (T21) contribute to the phenotypic characteristics and heterogeneity in Down syndrome (DS). In order to determine the methylation differences in T21 without interference of the interindividual genomic variation, we have used fetal skin fibroblasts from monozygotic (MZ) twins discordant for T21. We also used skin fibroblasts from MZ twins concordant for T21, normal MZ twins without T21, and unrelated normal and T21 individuals. Reduced Representation Bisulfite Sequencing (RRBS) revealed 35 differentially methylated promoter regions (DMRs) (Absolute methylation differences = 25%, FDR < 0.001) in MZ twins discordant for T21 that have also been observed in comparison between unrelated normal and T21 individuals. The identified DMRs are enriched for genes involved in embryonic organ morphogenesis (FDR = 1.60 e -03) and include genes of the HOXB and HOXD clusters. These DMRs are maintained in iPS cells generated from this twin pair and are correlated with the gene expression changes. We have also observed an increase in DNA methylation level in the T21 methylome compared to the normal euploid methylome. This observation is concordant with the up regulation of DNA methyltransferase enzymes (DNMT3B and DNMT3L) and down regulation of DNA demethylation enzymes (TET2 and TET3) observed in the iPSC of the T21 versus normal twin. Altogether, the results of this study highlight the epigenetic effects of the extra chromosome 21 in T21 on loci outside of this chromosome that are relevant to DS associated phenotypes.
Understanding and Caring for the Distressed Patient With Multiple Medically Unexplained Symptoms

Background: Although physicians commonly encounter patients with complicated medical problems, some have a mix of unexplained medical symptoms and distress that can seem overwhelming to patient and physician alike. Methods: We describe a model for thinking about and helping these complex patients. The model was developed from our personal clinical experience as primary care psychiatric consultants, as well as from a review of the literature using such key words as “difficult,” “frustrating,” and “somatization. ” Results: The model involves understanding predisposing factors that render the patient vulnerable to the development of a disabling condition, precipitating factors that initiate an episode of illness, and perpetuating factors that maintain maladaptive illness behaviors with time. Conclusions: Awareness of these factors allows the clinician not only to tolerate and gradually unravel the complicated interactions that create and sustain distress in patients with multiple medically unexplained symptoms, but also devise practical and effective management strategies for these complex patients.
Public Environmental Knowledge: A Statewide Survey

Abstract The environment as an issue has been prominently before the public for almost two decades. Yet the question of how much the public knows about their environment or about environmental issues has seldom been considered in the research literature. Using data from a statewide survey, this paper examines the general level of public environmental knowledge and analyzes the sociodemographic characteristics correlated with such knowledge. The results indicate that public environmental knowledge remains painfully low, and that the major correlates of environmental knowledge are education, income, and sex. The need for the development of environmental knowledge scales that can be applied across a variety of research is discussed.
Patients with atherosclerosis may have increased circulating levels of 27‐hydroxycholesterol and cholestenoic acid

Extrahepatic sterol 27‐hydroxylase (CYP27) appears to have a role in the elimination of excess cholesterol from various cells, particularly macrophages, and there is a net flux of 27‐hydroxyycholesterol and its metabolites from different extrahepatic sources to the liver. In this study we tested the hypothesis that patients with advanced atherosclerosis may have higher levels of 27‐oxygenated products in the circulation than control subjects. Concordant with previous studies, a strong correlation was observed between circulating levels of 27‐hydroxycholesterol and cholesterol, in both healthy subjects and subjects with hypercholesterolemia and documented atherosclerosis. A group of male subjects with normal or only slightly elevated serum cholesterol and rapidly progressing carotid atherosclerosis (n = 20) had serum levels of 27‐oxygenated cholesterol not statistically different from those of a matched group of subjects with little or no development of atherosclerosis (n = 20). The situation was similar in a group of patients (n = 20) with advanced general atherosclerosis associated with severe clinical symptoms. Among the two groups of patients with atherosclerosis, a few patients had relatively high levels of 27‐oxygenated products. Among the healthy controls, two healthy volunteers (brother and sister) were found to have high levels of 27‐hydroxycholesterol, most probably due to genetic reasons. The possibility is discussed that the high levels of 27‐oxygenated products in the circulation of a few patients with atherosclerosis may be related to high amounts of active macrophages present in atherosclerotic lesions. In view of the number of factors that could affect the levels in the circulation, other explanations cannot be ruled out. At the present state of knowledge, measurements of circulating levels of 27‐oxygenated metabolites do not seem to add useful information about the atherosclerotic process.
Amplitude-preserved processing and analysis of the Mobil AVO data set 1

Mobil Oil has released a comprehensive seismic and well-log data set from the North Sea to benchmark AVO techniques. We present our results on amplitude-preserved data processing and analysis of the Mobil AVO data. First, we apply a source and receiver consistent amplitude balancing to the seismic data, which reduces source and receiver amplitude variance from about 8% and 15% respectively, to within a few percent scatter. Next, we apply a time-domain conjugate-gradient multiple-suppression technique to remove multiple reflection energy and simultaneously preserve and enhance primary-reflection AVO amplitudes. We perform unmigrated AVO analyses and find that the multiple-suppressed data correlate better with the well-log data than the unprocessed data. A prestack migration/inversion of the multiple-suppressed data shows a clear improvement over unmigrated AVO analysis, and reveals an undrilled graben block in the center of the line that exhibits a positive hydrocarbon indicator anomaly.
Exploring the Impact of Birth Country Travel on Korean Adoptees

ABSTRACT Organized birth country travel for Korean adoptees within the context of post-adoptive services has been prevalent since the 1970s. It is estimated that approximately a dozen different heritage tours have escorted groups of more than 1,000 people, comprised of international adoptees and their families, within the past few years (Gubernick, 2002). However, little is known about the impact of such travel on adoptees and their families or how to support them. These emotionally charged sojourns are much more than just a summer vacation for adoptees and their families: They sometimes result in reunification with biological family and may constitute the first contact adoptees have with their birth country since placement. There have been approximately 150,000 foreign adoptions of Korean children since 1958 with more than 100,000 of the placements in the United States (The Evan B. Donald Adoption Institute, n.d.). The scope of post-adoptive services has widened over the past 45 years to encompass birth country travel as adoptees, parents, adoption researchers, and professionals have come to recognize that racial and ethnic heritage are integral to identify formation in transracial adoptees (Bergquist, 2000; Kim, 1978; Meier, 1999; Vonk, 1999, Wilkinson, 1985). This research contributes to the literature uniquely by examining the effect that birth country travel had on adoptees' identification to adoptive and birth cultures and the meaning adoptees assign to the experience. The finding can inform professionals, parents, and adoptees of the role of birth country travel in post-adoptive sevices.
Frequency Synchronization for Massive MIMO Multi-User Uplink

In this paper, we propose a new frequency synchronization scheme for multiuser orthogonal frequency division multiplexing (OFDM) uplink with a large-scale uniform linear array (ULA) at base station (BS). Considering that the incident signal at BS from each user can be restricted within a narrow angular spread, the proposed scheme performs carrier frequency offset (CFO) estimation for each user individually through a \textit{joint spatial- frequency alignment} procedure. The basic idea behind is that with sufficient spatial dimension, the multiuser interference (MUI) effect can be effectively mitigated via beamforming with the steering vectors corresponding to any direction of arrival (DOA) of each user. A multi-branch receive beamforming is further designed for each user which results in an equivalent single user transmission model and the conventional single-user channel estimation and data detection can be carried out. We show that the proposed CFO estimation can be applied efficiently with the aided of fast Fourier transform (FFT). The theoretical CFO estimation performance analysis is also conducted. Various numerical results are provided to verify the proposed studies.
Individual and spousal education, mortality and life expectancy in Switzerland: a national cohort study

Background Household measures of socioeconomic position may better account for the shared nature of material resources, lifestyle, and social position of cohabiting persons, but household measures of education are rarely used. We aimed to evaluate the association of combined educational attainment of married couples on mortality and life expectancy in Switzerland. Methods The study included 3 496 163 ever-married persons aged ≥30 years. The 2000 census was linked to mortality records through 2008. Mortality by combined educational attainment was assessed by gender-age-specific HRs, with 95% CIs from adjusted models, life expectancy was derived using abridged life tables. Results Having a less educated partner was associated with increased mortality. For example, the HR comparing men aged 50–64 years with tertiary education married to women with tertiary education to men with compulsory education married to women with compulsory education was 2.05 (1.92–2.18). The estimated remaining life expectancy in tertiary educated men aged 30 years married to women with tertiary education was 4.6 years longer than in men with compulsory education married to women with compulsory education. The gradient based on individual education was less steep: the HR comparing men aged 50–64 years with tertiary education with men with compulsory education was 1.74 (1.67–1.81). Conclusions Using individual educational attainment of married persons is common in epidemiological research, but may underestimate the combined effect of education on mortality and life expectancy. These findings are relevant to epidemiologic studies examining socio-demographic characteristics or aiming to adjust results for these characteristics.
Validation of the UPPS impulsive behaviour scale: a four‐factor model of impulsivity

The current study attempts to clarify the multi‐faceted nature of impulsivity through the use of the four‐factor UPPS Impulsive Behaviour scale. In order to build the nomological network surrounding this scale, the UPPS was administered to individuals with borderline personality disorder (BPD), pathological gamblers (PG), alcohol abusers (divided into two groups based on the presence of antisocial features), and a control group. Several of the UPPS scales (e.g. Urgency, lack of Premeditation, and Sensation Seeking) differentiated the BPD, PG, and alcohol abusers with antisocial features from a group of non‐antisocial alcohol abusers and a control group. Overall, the UPPS scales accounted for between 7% (pathological gambling) and 64% (borderline personality disorder features) of the overall variance in the psychopathology measures. Individual UPPS scales also made unique contributions to several of these disorders, which may provide insight into which of these personality traits may predispose individuals to behave in maladaptive or problematic ways. The results provide support for the differentiation of impulsivity‐related constructs into the current four‐factor model. Copyright © 2005 John Wiley & Sons, Ltd.
Developing and Testing an Integrative Model of the Work–Family Interface

Abstract An integrative model of the work–family interface was developed and tested. This model extends prior work by Frone, Russell, and Cooper (1992a). Although the present model adopts the distinction between work-to-family and family-to-work conflict, several important changes have been incorporated. First, a more explicit attempt is made to model the reciprocal (i.e., feedback) relations between work and family life. Second, a distinction is drawn between proximal and distal predictors of work–family conflict. Third, the relations between work–family conflict and role-related affect have been differentiated into predictive and outcome relations. Finally, role-related behavior and behavioral intentions have been explicitly incorporated into the model. Data were obtained from a sample of 372 employed adults who were married and/or parents. The model was tested with structural equation modeling techniques and the results were supportive. The present model provides a general framework to help organize past research and guide future research on the work–family interface.
Population Pharmacokinetics of Methotrexate in Children with Lymphoid Malignancy

Parameter Mean [95% CI] % IIV (SE) Coefficient of CL (L/h) 7.95 [6.51, 9.39] 31.9 (22.3) Exponent for WT on CL 0.308 [0.217, 0.399] RFC1 on CL 0.919 [0.883, 0.955] V1 (L/25 kg) 14.2 [10.1, 18.3] 49.2 (32.9) V2 (L) 3.81 [2.91, 4.71] 45.9 (39.1) Q (L/h) 0.132 [0.104, 0.160] 64.2 (46.4) Between-occasion variability κCL (L/h) 0.97 (0.48) Residual variability σ1 (%CV) 67.9 (34.5) σ2 (μmol/L) 0.065 (0.048) y = 5.5827x
Convergent Algorithm Based on Carleman Estimates for the Recovery of a Potential in the Wave Equation

This article develops the numerical and theoretical study of the reconstruction algorithm of a potential in a wave equation from boundary measurements, using a cost functional built on weighted energy terms coming from a Carleman estimate. More precisely, this inverse problem for the wave equation consists in the determination of an unknown time-independent potential from a single measurement of the Neumann derivative of the solution on a part of the boundary. While its uniqueness and stability properties are already well known and studied, a constructive and globally convergent algorithm based on Carleman estimates for the wave operator was recently proposed in [BdBE13]. However, the numerical implementation of this strategy still presents several challenges, that we propose to address here.
Squares of Menger-bounded groups

Using a portion of the Continuum Hypothesis, we prove that there is a Menger-bounded (also called o-bounded) subgroup of the Baer-Specker group ℤ ℕ , whose square is not Menger-bounded. This settles a major open problem concerning boundedness notions for groups and implies that Menger-bounded groups need not be Scheepers-bounded. This also answers some questions of Banakh, Nickolas, and Sanchis.
Dynamic TDD Support in Macrocell-Assisted Small Cell Architecture

Dynamic allocation of subframes to uplink (UL) or downlink (DL) in time division duplex (TDD), termed `Dynamic TDD,' has been studied by the 3rd Generation Partnership Project (3GPP) since the Long Term Evolution (LTE) Release 11 timeframe. At the same time, 3GPP is also standardizing macrocell-assisted small cell heterogeneous architectures for inclusion in LTE Release 12 as a solution offering high data rate to user terminals (UEs) along with high system capacity through spatial reuse of spectrum. In this paper, we focus on a particular small cell architecture proposed by DOCOMO, known as the Phantom Cell architecture, which provides the option to support dynamic TDD. For an arbitrarily-located UE in a small cell network, we apply results from stochastic geometry to derive expressions for the distribution of DL signal to interference plus noise ratio (SINR) at an arbitrary UE and the distribution of UL SINR at its serving base station (BS). The analytical results are verified by system level simulations. These results can be used to study aspects of system design for small cells, and the sensitivity of SINR to the extent of synchronization across small cells employing dynamic TDD. In order to deal with the severe inter-cell interference (ICI) problem in dynamic TDD, we further propose a frequency domain interference coordination technique. Finally, system level simulations based on more realistic system models and assumptions are conducted to evaluate the performance of dynamic TDD systems and the proposed interference coordination technique.
The evolution of portfolio rules and the capital asset pricing model

The aim of this paper is to test the performance of capital asset pricing model (CAPM) in an evolutionary framework. We model an economy where a heterogeneous population of long-lived agents invest their wealth according to different portfolio rules, and prove that traders who either “believe” in CAPM and use it as a rule of thumb, or are endowed with genuine mean-variance preferences, under some very weak conditions, vanish in the long run.We show that a sufficient condition to drive CAPM or mean-variance traders’ wealth shares to zero is that an investor endowed with a logarithmic utility function enters the market.
Age and sexual risk among Black men who have sex with men in South Africa: The mediating role of attitudes toward condoms

The results of research linking age and sexual risk among men who have sex with men have been inconsistent. This study assessed the relationship between age and sexual risk among 193 Black men who have sex with men in Pretoria. Older men who have sex with men reported engaging in more frequent unprotected insertive anal intercourse. We examined whether components of Information–Motivation–Behavioral Skills model mediated this relationship. Results showed that (1) older age predicts less positive attitudes toward condoms, (2) less positive attitudes predict more frequent unprotected insertive anal intercourse, and (3) attitudes mediate the relationship between age and frequency of unprotected insertive anal intercourse. We consider two possible explanations for these findings: a developmental trajectory and a cohort effect.
The mediating effect of quality of work life on the relationship between career development and psychological well-being

This study investigated an integrative of psychological well-being of public service employee. This study tested a mediation model consisting of psychological well-being as the dependent variable, career development as the independent variable and quality of work life as the mediator. A total of 429 white-collar workers employed in a public service participated in this study. An analysis of the results found career development and quality of work life were related to psychological well-being. The multiple regression analyses indicated that quality of work life partially mediates the relationship between career development and psychological well-being. These findings appeared to confirm that career development and quality of work life enhanced employee psychological well-being. The implication of this study is that it does contribute to understanding of the ways by which the management can endeavor to increase employee well-being based on the needs of the employee and the needs of the organization.
Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens

Estrogen receptors α (ESR1) and β (ESR2) play central roles in folliculogenesis and therefore in reproductive biology. In the present study, two single nucleotide polymorphisms (SNPs) were identified in the ESR1 and ESR2 genes using PCR-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing. One of the identified SNPs, a T1101C transition located within exon 4 of the ESR1 gene, was significantly associated with hen-housed egg production (HHEP) at 30, 43, 57 and 66 weeks of age (P<0.05), and egg weight (EW) at 30 weeks (P<0.05). Another SNP, a G1755A transition leading to a non-synonymous substitution (valine 459-to-isoleucine) located within exon 8 of the ESR2 gene, was also markedly correlated with the HHEP at 30, 43, 57 and 66 weeks of age (P<0.05), and EW at 30 weeks (P<0.05). A greater proportion of the additive variance was explained by the SNPs for most of the associated egg production traits (>1%). Furthermore, the results of the combined genotype-based association analysis supported the finding that the two SNPs were associated with the traits under a study. Taken together, our findings suggest that the two sequence variations in the ESR1 and ESR2 genes may provide promising genetic markers for the early selection and prediction of advantageous phenotypes in chicken breeding.