Miracle-dz/UniFAR-FTUs huggingface dataset:
Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced non-small cell lung cancer in Chinese population: A retrospective study

Objectives To evaluate the clinical efficacy and toxicity of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) for patients with locally advanced non-small cell lung cancer (NSCLC). Results All patients completed definitive radiotherapy and 74 (85.1%) patients administrated platinum-based chemotherapy. The median radiation dose was 50.4Gy to PTV and 64.4 Gy simultaneously to the PGTV. The overall response rate (ORR) was 57.5% (50/87). The median duration of follow up was 24.6 months. The 1, 2, 3-year local control rate was 79.0%, 66.1%, and 60.5%, respectively. The 1, 2, 3-year overall survival (OS) rate was 89.7%, 56.7%, and 30.6%, respectively. Subgroup analysis showed that the median OS in concurrent chemoradiation (CCRT) was much better than non-CCRT (35.7 vs. 26.4 months) (HR: 0.52, 95% CI: 0.32–0.95, P = 0.033). Twenty-two (25.3%) patients experienced acute grade 3 esophagitis and 10 (11.5%) experienced acute grade ≥ 3 radiation pneumonitis. There were 2 (2.6%) late grade 3 pulmonary toxicity and no late grade ≥ 3 esophageal toxicity was observed. Materials and Methods A total of 87 patients with locally advanced NSCLC who received SIB-IMRT from Jan. 2009 to Dec. 2012 in our hospital were retrospectively analyzed. Male accounted for 88.5%, with a median age of 61 years old. The SIB-IMRT plans were designed to deliver 50.4–64.0 Gy in 28–33 fractions (1.8–2.1 Gy/fraction) to PTV while simultaneously delivering 60.0–74.3 Gy in 28–33 fractions (2.0–2.5 Gy/fraction) to PGTV. Conclusions SIB-IMRT, especially with concurrent chemotherapy, appears to be an effective and safe option to treat patients with locally advanced NSCLC. More prospective clinical studies should be warranted.
Requirements discovery during the testing of safety-critical software

This paper describes the role of requirements discovery during the testing of a safety-critical software system. Analysis of problem reports generated by the integration and system testing of an embedded, safety-critical software system identified four common mechanisms for requirements discovery and resolution during testing: (1) Incomplete requirements, resolved by changes to the software, (2) Unexpected requirements interactions, resolved by changes to the operational procedures, (3) Requirements confusion by the testers, resolved by changes to the documentation, and (4) Requirements confusion by the testers, resolved by a determination that no change was needed The experience reported here confirms that requirements discovery during testing is frequently due to communication difficulties and subtle interface issues. The results also suggest that "false positive" problem reports from testing (in which the software behaves correctly but unexpectedly) provide a rich source of requirements information that can be used to reduce operational anomalies in critical systems.
A study of factors influencing intention to use traffic information applications on smartphones in Bangkok, Thailand

Traffic information applications been proposed as a potential solution for traffic congestion problem in Bangkok, Thailand. However, the tendency of application usage has not increased as expected. Thus, this study is conducted to investigate the factors influencing on travelers' intention to use traffic information applications on smartphones using modified Technology Acceptance Model (TAM) with the emphasis on the differences in influencing factors between long-distance travelers and short distance travelers. The results show that the attitude toward using application has the powerful effect on behavioral intention to use application in both groups of respondents and perceived usefulness, perceived ease of use, subjective norm, perceived enjoyment and trust in application are the predictors of the attitude toward using application in both groups as well. However, the strongest determinant of long-distance travelers' attitude is trust in applications. Perceived usefulness is the strongest determinants of short-distance-travelers' attitudes. Moreover, long-distance travelers tend to be more interested in the reliability of application than short-distance travelers. Meanwhile, short-distance travelers tend to be more interested in the ease of use of application than long-distance travelers.
Arabidopsis Annexin1 Mediates the Radical-Activated Plasma Membrane Ca2+- and K+-Permeable Conductance in Root Cells[W]

The Arabidopsis thaliana root cell plasma membrane contains a calcium channel that is activated by oxidizing conditions and operates in cell growth. It was identified here as the most abundant member of the Arabidopsis annexins. These are soluble proteins that can undergo conditional attachment to or insertion into membranes. Plant cell growth and stress signaling require Ca2+ influx through plasma membrane transport proteins that are regulated by reactive oxygen species. In root cell growth, adaptation to salinity stress, and stomatal closure, such proteins operate downstream of the plasma membrane NADPH oxidases that produce extracellular superoxide anion, a reactive oxygen species that is readily converted to extracellular hydrogen peroxide and hydroxyl radicals, OH•. In root cells, extracellular OH• activates a plasma membrane Ca2+-permeable conductance that permits Ca2+ influx. In Arabidopsis thaliana, distribution of this conductance resembles that of annexin1 (ANN1). Annexins are membrane binding proteins that can form Ca2+-permeable conductances in vitro. Here, the Arabidopsis loss-of-function mutant for annexin1 (Atann1) was found to lack the root hair and epidermal OH•-activated Ca2+- and K+-permeable conductance. This manifests in both impaired root cell growth and ability to elevate root cell cytosolic free Ca2+ in response to OH•. An OH•-activated Ca2+ conductance is reconstituted by recombinant ANN1 in planar lipid bilayers. ANN1 therefore presents as a novel Ca2+-permeable transporter providing a molecular link between reactive oxygen species and cytosolic Ca2+ in plants.
Hypoxia-Inducible Factor 1α in Clear Cell Renal Cell Carcinoma

Purpose: Hypoxia-inducible factor-1α (HIF-1α) plays an important role in tumoral adaptation to hypoxic conditions by serving as a transcription factor for several crucial proteins, including vascular endothelial growth factor and carbonic anhydrase IX (CAIX). Here, we evaluated the significance of HIF-1α in renal cell carcinoma (RCC). Experimental Design: Immunohistochemical analysis was done on a tissue microarray constructed from paraffin-embedded primary tumor specimens from 357 patients treated by nephrectomy for RCC. Nuclear expression was evaluated by a single pathologist who was blinded to outcome. The expression levels were associated with pathologic variables and survival. Results: HIF-1α expression was greater in RCC than in benign tissue. Clear cell RCC showed the highest expression levels. In clear cell RCC, HIF-1α was significantly correlated with markers of apoptosis (p21, p53), the mammalian target of rapamycin pathway (pAkt, p27), CXCR3, and proteins of the vascular endothelial growth factor family. HIF-1α was correlated with CAIX and CAXII in localized, but not in metastatic RCC. HIF-1α expression predicted outcome in metastatic patients: patients with high HIF-1α expression (>35%) had significantly worse survival than patients with low expression (≤35%); median survival, 13.5 versus 24.4 months, respectively (P = 0.005). Multivariate analysis retained HIF-1α and CAIX expression as the strongest independent prognostic factors for patients with metastatic clear cell RCC. Conclusions: HIF-1α is an important independent prognostic factor for patients with metastatic clear cell RCC. Because HIF-1α and CAIX are independently and differentially regulated in metastatic clear cell RCC, both tumor markers can be complementary in predicting prognosis.
Demonstrating Intertumoural Differences in Vascular-Metabolic Phenotype with Dynamic Contrast-Enhanced CT-PET

Purpose. To assess whether the differences in vascular-metabolic relationships between lymphoma masses and colorectal liver metastases predicted from previous histopathological studies can be demonstrated by dynamic contrast-enhanced CT (DCE-CT) combined with fluorodeoxyglucose positron emission tomography (FDG-PET). Methods. DCE-CT and FDG-PET studies were drawn from an imaging archive for patients with either lymphoma masses (n = 11) or hepatic metastases from colorectal cancer (CRM: n = 12). Tumour vascularity was assessed using DCE-CT measurements of perfusion. Tumour glucose metabolism was expressed as the mean FDG Standardised Uptake Value (SUVFDG). The relationship between metabolism and vascularity in each group was assessed from SUVFDG /perfusion ratios and Pearson correlation coefficients. Results. An SUVFDG threshold of 3.0 was used to designate lymphoma masses as active (AL, n = 6) or inactive lymphoma (IL, n = 5). Tumour perfusion was significantly higher in AL (0.65 mL/min/mL) than CRM (0.37 mL/min/mL: P = .031) despite similar SUVFDG (5.05 and 5.33, resp.). AL demonstrated higher perfusion values than IL (0.24 mL/min/mL: P = .006). SUVFDG/perfusion was significantly higher in CRM (15.3 min) than IL (4.2 min, P < .01). There was no correlation between SUVFDG and perfusion for any patient group.
Faith after an Earthquake: A Longitudinal Study of Religion and Perceived Health before and after the 2011 Christchurch New Zealand Earthquake

On 22 February 2011, Christchurch New Zealand (population 367,700) experienced a devastating earthquake, causing extensive damage and killing one hundred and eighty-five people. The earthquake and aftershocks occurred between the 2009 and 2011 waves of a longitudinal probability sample conducted in New Zealand, enabling us to examine how a natural disaster of this magnitude affected deeply held commitments and global ratings of personal health, depending on earthquake exposure. We first investigated whether the earthquake-affected were more likely to believe in God. Consistent with the Religious Comfort Hypothesis, religious faith increased among the earthquake-affected, despite an overall decline in religious faith elsewhere. This result offers the first population-level demonstration that secular people turn to religion at times of natural crisis. We then examined whether religious affiliation was associated with differences in subjective ratings of personal health. We found no evidence for superior buffering from having religious faith. Among those affected by the earthquake, however, a loss of faith was associated with significant subjective health declines. Those who lost faith elsewhere in the country did not experience similar health declines. Our findings suggest that religious conversion after a natural disaster is unlikely to improve subjective well-being, yet upholding faith might be an important step on the road to recovery.
Law, Development, and the Ethiopian Revolution

This thesis explores a series of middle-range hypotheses concerning the interrelation of law and development. These hypotheses are made concrete enough to serve as policy prescriptions by applying them to the problems of Ethiopia, a country which displays most of the development constraints that have been identified in other Third World countries. Development is best understood as a dynamic process, as the broadening of subsistence and small-scale economic, political, legal and social 'markets' that effects a cumulative growth in a wide variety of resources. In Ethiopia, given her highly stratified and fragmented societies, this entails a socio-economic equalisation and integration, a wholesale structural transformation rather than the narrow policies of an economic growth advocated by many development theorists. The magnitude of this transformation, the manifest need for extensive and intensive development planning and the socialist predilections of Ethiopia's revolutionary military rulers (the Derg) suggest that massive state intervention in the economy is both inevitable and the only feasible path to an Ethiopian development which is, nevertheless, fraught with many hazards. It is therefore impossible to segregate economic activity from what is, in Ethiopia, an undifferentiated mass of law, politics and administration. The largest single bottleneck to Ethiopian development is the virtual absence of any political development registered under Haile Selassie or the Derg. The role of law in eliminating an Ethiopian "soft state" (Myrdal's term), which is far from soft on the poor and powerless, is surveyed and law's role in the aggregation, allocation and delegation of a variety of resources, in the formulation and implementation of interrelated policies, and in the amelioration of species of injustice is analysed in detail.
Visual memory and learning in extremely low-birth-weight/extremely preterm adolescents compared with controls: a geographic study.

BACKGROUND Contemporary data on visual memory and learning in survivors born extremely preterm (EP; <28 weeks gestation) or with extremely low birth weight (ELBW; <1,000 g) are lacking. METHODS Geographically determined cohort study of 298 consecutive EP/ELBW survivors born in 1991 and 1992, and 262 randomly selected normal-birth-weight controls. RESULTS Visual learning and memory data were available for 221 (74.2%) EP/ELBW subjects and 159 (60.7%) controls. EP/ELBW adolescents exhibited significantly poorer performance across visual memory and learning variables compared with controls. Visual learning and delayed visual memory were particularly problematic and remained so after controlling for visual-motor integration and visual perception and excluding adolescents with neurosensory disability, and/or IQ <70. Male EP/ELBW adolescents or those treated with corticosteroids had poorer outcomes. CONCLUSION EP/ELBW adolescents have poorer visual memory and learning outcomes compared with controls, which cannot be entirely explained by poor visual perceptual or visual constructional skills or intellectual impairment.
Retroactive Interference and Mental Practice Effects on Motor Performance: A Pilot Study

This study examined the effect of similar versus dissimilar retroactive interference on the mental practice effects for performing a novel motor skill. Research has shown that mental practice of a motor task can interfere with learning and performance of the task; however, little is known about how different retroactive interference activities affect mental practice effects. 90 volunteers ages 18 to 51 years (M = 26.8, SD = 9.6) completed a pre-test and post-test of 10 sets of five trials of a throwing task with the non-preferred hand. In the practice phase, participants mentally practiced the throwing task and then mentally practiced a task that was similar, dissimilar, or completed an unrelated reading task. Performance for all groups improved from pre- to post-test; however, there were no differences in increases for the three groups. The findings suggest that mental practice of similar and dissimilar tasks produced no significant interference in performance.
Sensory‐Specific Satiation and Satiety

Abstract: As a food is eaten, the pleasantness and desire to eat that food decline relative to other foods that are not eaten. This change in pleasantness and desire is described as sensory-specific satiety (SSS) or satiation. This phenomenon is thought to be important as a basic, biologically adaptive behaviour, since it describes satiation to the sensory characteristics of a highly liked food and promotes intake of other foods. The potentially adaptive value for omnivores is clear: SSS ensures intake of a variety of foods and not just the most favoured. Whilst the decrement in subjective pleasantness would appear to be a simple form of response habituation, systematic study of SSS does not support this assumption. SSS does not seem to be subject to dishabituation, is not affected by stimulus intensity, and is not potentiated with multiple opportunities to develop such SSS. Thus SSS might constitute a special form of response habituation, characterised by a decrease in affective responding to a specific food, yet evidence suggests that SSS is more functionally similar to stimulus satiation than response habituation. Although biologically useful, SSS serves us less well in an environment where food is highly palatable, varied, abundant and cheap, especially since, despite reduced liking for recently eaten foods, intake can remain high.
Evaluating Auditory Performance Limits: II. One-Parameter Discrimination with Random-Level Variation

Previous studies have combined analytical models of stochastic neural responses with signal detection theory (SDT) to predict psychophysical performance limits; however, these studies have typically been limited to simple models and simple psychophysical tasks. A companion article in this issue (Evaluating Auditory Performance Limits: I) describes an extension of the SDT approach to allow the use of computational models that provide more accurate descriptions of neural responses. This article describes an extension to more complex psychophysical tasks. A general method is presented for evaluating psychophysical performance limits for discrimination tasks in which one stimulus parameter is randomly varied. Psychophysical experiments often randomly vary a single parameter in order to restrict the cues that are available to the subject. The method is demonstrated for the auditory task of random-level frequency discrimination using a computational auditory nerve (AN) model. Performance limits based on AN discharge times (all-information) are compared to performance limits based only on discharge counts (rate place). Both decision models are successful in predicting that random-level variation has no effect on performance in quiet, which is the typical result in psychophysical tasks with random-level variation. The distribution of information across the AN population provides insight into how different types of AN information can be used to avoid the influence of random-level variation. The rate-place model relies on comparisons between fibers above and below the tone frequency (i.e., the population response), while the all-information model does not require such across-fiber comparisons. Frequency discrimination with random-level variation in the presence of high-frequency noise is also simulated. No effect is predicted for all-information, consistent with the small effect in human performance; however, a large effect is predicted for rate-place in noise with random-level variation.
Brain Interleukin-1 Facilitates Learning of a Water Maze Spatial Memory Task in Young Mice

The proinflammatory cytokine interleukin-1 (IL-1) is produced by many types of cells, including immune cells in the periphery and glia and neurons in the brain. The type I IL-1 receptor (IL-1r1) is primarily responsible for transmitting the inflammatory effects of IL-1 and mediates several biological functions by binding to either IL-1α or IL-1β. IL-1β activation is associated with hippocampus-dependent memory tasks. Although IL-1β impairs spatial memory under certain pathophysiological conditions, IL-1β may be required for the normal physiological regulation of hippocampal plasticity and memory. In addition, brain IL-1β levels are thought to change in the hippocampus in an age-dependent manner. These findings suggest that IL-1β may have a beneficial, temporary effect on learning and memory in young mice, but the matter remains unclear. Therefore, we hypothesized that hippocampal IL-1β has a beneficial effect on spatial learning and memory in young mice via IL-1r1, which is diminished in adults. We investigated the performance of young (3-month-old) and adult (6-month-old) wild-type mice, IL-1β knockout mice (IL-1βko) and IL-1r1 knockout mice (IL-1r1ko) in learning a spatial memory task with a fixed platform in a water maze (WM) and measured the levels of IL-1β and IL-1α in the hippocampus and cortex of adult and young mice by using homogeneous time-resolved fluorescence (HTRF). Learning was significantly impaired in the training trials of the WM spatial memory task in young IL-1βko and IL-1r1ko mice but not in adult IL-1βko and IL-1r1ko mice. Moreover, young IL-1r1ko mice but not IL-1βko mice showed an impairment in long-term memory extinction, suggesting that IL-1α might facilitate memory extinction. In this study, the cytokine assay using HTRF did not indicate a higher expression of hippocampal IL-1 in young mice but cortical IL-1β and IL-1α were significantly increased in adult mice. We need to investigate the role of cortical IL-1 and the local IL-1 expression in the hippocampal neurons in the future.
Theories of Psychotherapy

I.PSYCHOANALYTIC AND NEOANALYTIC APPROACHES. 1.Psychoanalysis: Freud. 2.Analytical Psychotherapy: Jung. 3.Individual Psychology: Adler. 4.Psychoanalytic Object Relations Theory and Therapy: Fairbairn, Winnicott, and Guntrip. II.LEARNING THEORY APPROACHES. 5.Reinforcement Theory and Psychoanalytic Therapy: Dollard and Miller. 6.Behavior Therapy: Wolpe. III.COGNITIVE APPROACHES. 7.Rational Emotive Psychotherapy: Ellis. 8.Cognitive Therapy: Beck. 9.Cognitive-Behavior Modification: Meichenbaum. IV.PERCEPTUAL-PHENOMENOLOGICAL APPROACHES. 10.Psychology of Personal Constructs and Psychotherapy: Kelly. 11.Transactional Analysis: Berne. 12.Gestalt Therapy: Perls. 13.Client-Centered Therapy: Rogers. V.EXISTENTIAL PSYCHOTHERAPY. 14.Logotherapy: Frankl. VI.CONCLUSION: DIVERGENCE AND CONVERGENCE IN PSYCHOTHERAPY. 15.Divergence. 16.Convergence.
EXAMINING LEARNING ALGORITHMS FOR TEXT CLASSIFICATION IN DIGITAL LIBRARIES

Information presentation in a digital library plays important role especially in improving the usability of collections and helping users to get started with the collection. One approach is to provide an overview through large topical category hierarchies associated with the documents of a collection. But with the growth in the amount of information, this manual classification becomes a new problem for users. The navigation through the hierarchy can be a time-consuming and frustrating process. In this master thesis, we examine the performance of machine learning algorithms for automatic text classification. We examine three learning algorithms namely ID3, Instance Based Learning, and Naive Bayes to classify documents according to their category hierarchies. We focused on the effectiveness measurement such as recall, precision, the F1- measure, error, and the learning curve in learning a manually classified metadata collection from the Indonesian Digital Library Network (IndonesiaDLN), and we compare the results with an examination of the Reuters-21578 dataset. We summarize the algorithm that is most suitable for the digital library collection and the performance of the algorithms on these datasets.