Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Green Tea Gargling on the Prevention of Influenza Infection in High School Students: A Randomized Controlled Study

Background The anti-influenza virus activity of green tea catechins has been demonstrated in experimental studies, but clinical evidence has been inconclusive. School-aged children play an important role in the infection and spread of influenza in the form of school-based outbreaks. Preventing influenza infection among students is essential for reducing the frequency of epidemics and pandemics. As a non-pharmaceutical intervention against infection, gargling is also commonly performed in Asian countries but has not yet been extensively studied. Methods and Findings A randomized, open label, 2-group parallel study of 757 high school students (15 to 17 years of age) was conducted for 90 days during the influenza epidemic season from December 1st, 2011 to February 28th, 2012, in 6 high schools in Shizuoka Prefecture, Japan. The green tea gargling group gargled 3 times a day with bottled green tea, and the water gargling group did the same with tap water. The water group was restricted from gargling with green tea. The primary outcome measure was the incidence of laboratory-confirmed influenza using immunochromatographic assay for antigen detection. 757 participants were enrolled and 747 participants completed the study (384 in the green tea group and 363 in the water group). Multivariate logistic regression indicated no significant difference in the incidence of laboratory-confirmed influenza between the green tea group (19 participants; 4.9%) and the water group (25 participants; 6.9%) (adjusted OR, 0.69; 95%CI, 0.37 to 1.28; P = 0.24). The main limitation of the study is the adherence rate among high school students was lower than expected. Conclusions Among high school students, gargling with green tea three times a day was not significantly more efficacious than gargling with water for the prevention of influenza infection. In order to adequately assess the effectiveness of such gargling, additional large-scale randomized studies are needed. Trial Registration ClinicalTrials.gov NCT01225770
Sociability Impact on Learner’s Personality in Classroom and E- learning Environments: A Comparative Analysis to Help HRM Decisions

The purpose of this study is to compare the sociability and its impact on learner’s personality traits, in classroom and E-Learning settings to provide an insight for HRM decisions. We proposed that student’s sociability level differ between classroom and e-learning environments. We also identify that sociability is a good predictor for extroversion and openness to experience. For this cross sectional explanatory research about 534 respondents are identified with purposive sampling method. Results point out that there is significant difference in learner’s sociability, extroversion and openness to experience, in classroom and E-Learning environments. The study also established that sociability has statistically significant and positive relationship with openness to experience and extroversion. As there is not even a single study so far that have compared educational environment by using aforementioned variables in reference with development of personality, so the study is unique and a valuable contribution both in educational psychology and for decision making in HRM as well. The study will assist managers to find suitable personal for job. It will also help for training and development plan formation.
Automated Parameter Optimization of Classification Techniques for Defect Prediction Models

Defect prediction models are classifiers that are trained to identify defect-prone software modules. Such classifiers have configurable parameters that control their characteristics (e.g., the number of trees in a random forest classifier). Recent studies show that these classifiers may underperform due to the use of suboptimal default parameter settings. However, it is impractical to assess all of the possible settings in the parameter spaces. In this paper, we investigate the performance of defect prediction models where Caret — an automated parameter optimization technique - has been applied. Through a case study of 18 datasets from systems that span both proprietary and open source domains, we find that (1) Caret improves the AUC performance of defect prediction models by as much as 40 percentage points; (2) Caret-optimized classifiers are at least as stable as (with 35% of them being more stable than) classifiers that are trained using the default settings; and (3) Caret increases the likelihood of producing a top-performing classifier by as much as 83%. Hence, we conclude that parameter settings can indeed have a large impact on the performance of defect prediction models, suggesting that researchers should experiment with the parameters of the classification techniques. Since automated parameter optimization techniques like Caret yield substantially benefits in terms of performance improvement and stability, while incurring a manageable additional computational cost, they should be included in future defect prediction studies.
Purchase decision-making is modulated by vestibular stimulation

Purchases are driven by consumers’ product preferences and price considerations. Using caloric vestibular stimulation (CVS), we investigated the role of vestibular-affective circuits in purchase decision-making. CVS is an effective noninvasive brain stimulation method, which activates vestibular and overlapping emotional circuits (e.g., the insular cortex and the anterior cingulate cortex (ACC)). Subjects were exposed to CVS and sham stimulation while they performed two purchase decision-making tasks. In Experiment 1 subjects had to decide whether to purchase or not. CVS significantly reduced probability of buying a product. In Experiment 2 subjects had to rate desirability of the products and willingness to pay (WTP) while they were exposed to CVS and sham stimulation. CVS modulated desirability of the products but not WTP. The results suggest that CVS interfered with emotional circuits and thus attenuated the pleasant and rewarding effect of acquisition, which in turn reduced purchase probability. The present findings contribute to the rapidly growing literature on the neural basis of purchase decision-making.
Revisiting “ SCUDHunt ” and the Human Dimension of NCW : Some Thoughts

The “SCUDHunt” game-based experiments conducted by the CNA Corporation and ThoughtLink Inc during 2000–2002 explored Shared Situational Awareness (SSA) in a Network Centric Warfare (NCW) environment. Our paper re-analyses the results of those experiments, with a particular focus on the human dimension of the experimental results. We thereby significantly extend the conclusions of the original study, which was focused on technology issues rather than the human dimension. Our re-analysis demonstrates that differences between “good” and “bad” teams had a greater impact on mission effectiveness than any technology factor. It also shows that major contributors to mission effectiveness were good team dynamics, professional mastery, and ability to use the technology. Of these, team dynamics was the most important. Our re-analysis also illustrates the fact that the often lauded Shared Situational Awareness (SSA) is not an end in itself: poor teamwork and insufficient levels of professional mastery can lead to teams sharing agreement on incorrect assessments of the situation, sometimes with tragic results. Our conclusions underline the importance of the human element in the networked future force, and support the Australian emphasis on professional mastery. We conclude with some general observations and lessons learnt in the area of human experimentation for NCW.
The SNP-DCC model: a new methodology for risk management and forecasting

This paper generalizes the Dynamic Conditional Correlation (DCC) model of En- gle (2002) to incorporate a flexible non-Gaussian distribution based on Gram-Charlier expansions. The resulting semi-nonparametric (SNP)-DCC model admits a separate estimation of, in a first stage, the individual conditional variances under a Gaussian distribution and, in the second stage, the conditional correlations and the rest of the density parameters, thus overcoming the known "dimensionality curse" of the mul- tivariate volatility models. Furthermore the proposed SNP-DCC model solves the negativity problem inherent to truncated SNP densities providing a parametric struc- ture that may accurately approximate a target heavy-tailed distribution. We test the performance of a SNP-DCC model with respect to the (Gaussian)-DCC through an empirical application of density forecasting for portfolio asset returns data. Our results show that the proposed multivariate model provides a better in-sample fit and forecast of the portfolio returns distribution, being thus useful for financial risk forecasting and evaluation.
Transition Paths and Social Security Reform

A basic difference between a pay-as-you-go (PAYGO) public pension system and one with fully funded private accounts lies in the startup. From its inception, a PAYGO system can pass contributions from current workers to current retirees. A funded system must either spend decades accumulating tax revenues before beginning benefit payments, or society must provide external funds to create the system's initial account balances. This paper shows that the same logic governs reform of a PAYGO into a private account system. Presuming that only the second procedure above is feasible for reform, one would have to find external funds to create initial account balances. After that step, the new system could be autonomously viable.
Fundamental Frequency Peak Delay in Mandarin

Abstract Fundamental frequency (F₀) peak delay (henceforth peak delay) refers to the phenomenon that an F₀ peak sometimes occurs after the syllable it is associated with either lexically or prosodically. Although peak delay has been reported for various languages, the mechanism of its occurrence has so far remained unclear. In Mandarin, peak delay has been found to occur regularly in the rising (R) tone but not in the high (H) tone. The present study investigates the underlying mechanisms of peak delay by examining its relationship with tone, tonal context, and speech rate. An experiment was conducted to test the possibility that peak delay may occur also in the H tone in Mandarin if the H-carrying syllable is sufficiently shortened. Native speakers of Mandarin Chinese recorded three types of sentences each containing a H, a R, or a weakened H tone. The sentences were produced at three speech rates: normal, fast and slow. Analysis of F₀ contours and peak alignment revealed that at normal speech rate, peak delay occurred regularly in both the R and weakened H tones but only occasionally in the H tone; at slow speech rate, peak delay continued to occur regularly in the R tone but only occasionally in weakened H and rarely in the H tone; at fast speech rate, peak delay occurred not only regularly in the R and weakened H tones, but also frequently in the H tone. Results of F₀ contour alignment analysis indicate that peak delay occurs when there is a sharp F₀ rise near the end of a syllable, regardless of the cause of the rise. The finding of this study provides support for the view that, rather than due to actual misalignment between underlying pitch units and segmental units, much of the variability in the shape and alignment of F₀ contours in Mandarin is attributable to the interaction of underlying pitch targets with tonal contexts and articulatory constraints.
Visual Acuity Testing: Feedback Affects Neither Outcome nor Reproducibility, but Leaves Participants Happier

Assessment of visual acuity is a well standardized procedure at least for expert opinions and clinical trials. It is often recommended not giving patients feedback on the correctness of their responses. As this viewpoint has not been quantitatively examined so far, we quantitatively assessed possible effects of feedback on visual acuity testing. In 40 normal participants we presented Landolt Cs in 8 orientations using the automated Freiburg Acuity Test (FrACT, <michaelbach.de/fract. Over a run comprising 24 trials, the acuity threshold was measured with an adaptive staircase procedure. In an ABCDDCBA scheme, trial-by-trial feedback was provided in 2 x 4 conditions: (A) no feedback, (B) acoustic signals indicating correctness, (C)visual indication of correct orientation, and (D) a combination of (B) and (C). After each run the participants judged comfort. Main outcome measures were absolute visual acuity (logMAR), its test-retest agreement (limits of agreement) and participants’ comfort estimates on a 5-step symmetric Likert scale. Feedback influenced acuity outcome significantly (p = 0.02), but with a tiny effect size: 0.02 logMAR poorer acuity for (D) compared to (A), even weaker effects for (B) and (C). Test-retest agreement was high (limits of agreement: ± 1.0 lines) and did not depend on feedback (p>0.5). The comfort ranking clearly differed, by 2 steps on the Likert scale: the condition (A)–no feedback–was on average “slightly uncomfortable”, the other three conditions were “slightly comfortable” (p<0.0001). Feedback affected neither reproducibility nor the acuity outcome to any relevant extent. The participants, however, reported markedly greater comfort with any kind of feedback. We conclude that systematic feedback (as implemented in FrACT) offers nothing but advantages for routine use.
A DECAM SEARCH FOR AN OPTICAL COUNTERPART TO THE LIGO GRAVITATIONAL-WAVE EVENT GW151226

We report the results of a Dark Energy Camera optical follow-up of the gravitational-wave (GW) event GW151226, discovered by the Advanced Laser Interferometer Gravitational-wave Observatory detectors. Our observations cover 28.8 deg2 of the localization region in the i and z bands (containing 3% of the BAYESTAR localization probability), starting 10 hr after the event was announced and spanning four epochs at 2–24 days after the GW detection. We achieve 5 σ point-source limiting magnitudes of i ≈ 21.7 and z ≈ 21.5 , with a scatter of 0.4 mag, in our difference images. Given the two-day delay, we search this area for a rapidly declining optical counterpart with ≳ 3 σ significance steady decline between the first and final observations. We recover four sources that pass our selection criteria, of which three are cataloged active galactic nuclei. The fourth source is offset by 5.8 arcsec from the center of a galaxy at a distance of 187 Mpc, exhibits a rapid decline by 0.5 mag over 4 days, and has a red color of i − z ≈ 0.3 mag. These properties could satisfy a set of cuts designed to identify kilonovae. However, this source was detected several times, starting 94 days prior to GW151226, in the Pan-STARRS Survey for Transients (dubbed as PS15cdi) and is therefore unrelated to the GW event. Given its long-term behavior, PS15cdi is likely a Type IIP supernova that transitioned out of its plateau phase during our observations, mimicking a kilonova-like behavior. We comment on the implications of this detection for contamination in future optical follow-up observations.
SIRT1 performs a balancing act on the tight-rope toward longevity

Our recent study defined a new role for SIRT1 as a regulator of hepatic lipid metabolism. In the liver a major target of this sirtuin is the PPARα/PGC-1α signaling axis. Ablation of SIRT1 in the liver results in disrupted fatty acid oxidation, increased cellular stress, and elevations in proinflammatory cytokines. However, contrary to previous studies, we observed no changes in glucose production in the absence of SIRT1, despite impaired PGC-1α signaling. These findings point toward the involvement of other players in SIRT1-regulated hepatic metabolism. Here we discuss our findings, and comment on some of the controversy surrounding this protein in the current literature.
CS-SELEX Generates High-Affinity ssDNA Aptamers as Molecular Probes for Hepatitis C Virus Envelope Glycoprotein E2

Currently, the development of effective diagnostic reagents as well as treatments against Hepatitis C virus (HCV) remains a high priority. In this study, we have described the development of an alive cell surface -Systematic Evolution of Ligands by Exponential Enrichment (CS-SELEX) technique and screened the functional ssDNA aptamers that specifically bound to HCV envelope surface glycoprotein E2. Through 13 rounds of selection, the CS-SELEX generated high-affinity ssDNA aptamers, and the selected ssDNA aptamer ZE2 demonstrated the highest specificity and affinity to E2-positive cells. HCV particles could be specifically captured and diagnosed using the aptamer ZE2. A good correlation was observed in HCV patients between HCV E2 antigen-aptamer assay and assays for HCV RNA quantities or HCV antibody detection. Moreover, the selected aptamers, especially ZE2, could competitively inhibit E2 protein binding to CD81, an important HCV receptor, and significantly block HCV cell culture (HCVcc) infection of human hepatocytes (Huh7.5.1) in vitro. Our data demonstrate that the newly selected ssDNA aptamers, especially aptamer ZE2, hold great promise for developing new molecular probes, as an early diagnostic reagent for HCV surface antigen, or a therapeutic drug specifically for HCV.
Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease

Genome-wide association studies (GWAS) of chronic periodontitis (CP) defined by clinical criteria alone have had modest success to-date. Here, we refine the CP phenotype by supplementing clinical data with biological intermediates of microbial burden (levels of eight periodontal pathogens) and local inflammatory response (gingival crevicular fluid IL-1β) and derive periodontal complex traits (PCTs) via principal component analysis. PCTs were carried forward to GWAS (∼2.5 million markers) to identify PCT-associated loci among 975 European American adult participants of the Dental ARIC study. We sought to validate these findings for CP in the larger ARIC cohort (n = 821 participants with severe CP, 2031—moderate CP, 1914—healthy/mild disease) and an independent German sample including 717 aggressive periodontitis cases and 4210 controls. We identified six PCTs with distinct microbial community/IL-1β structures, although with overlapping clinical presentations. PCT1 was characterized by a uniformly high pathogen load, whereas PCT3 and PCT5 were dominated by Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, respectively. We detected genome-wide significant signals for PCT1 (CLEC19A, TRA, GGTA2P, TM9SF2, IFI16, RBMS3), PCT4 (HPVC1) and PCT5 (SLC15A4, PKP2, SNRPN). Overall, the highlighted loci included genes associated with immune response and epithelial barrier function. With the exception of associations of BEGAIN with severe and UBE3D with moderate CP, no other loci were associated with CP in ARIC or aggressive periodontitis in the German sample. Although not associated with current clinically determined periodontal disease taxonomies, upon replication and mechanistic validation these candidate loci may highlight dysbiotic microbial community structures and altered inflammatory/immune responses underlying biological sub-types of CP.
A COMPETITIVE INTERACTION AND DOMINANCE EXPERIMENT BETWEEN THE VEGETATIVE MARSH SPECIES PHRAGMITES AUSTRALIS AND SPARTINA CYNOSUROIDES UNDER ELEVATED SALINITY AND NITROGEN LEVELS

Title of Document: A COMPETITIVE INTERACTION AND DOMINANCE EXPERIMENT BETWEEN THE VEGETATIVE MARSH SPECIES PHRAGMITES AUSTRALIS AND SPARTINA CYNOSUROIDES UNDER ELEVATED NITROGEN AND SALINITY LEVELS Michelle L. Arthur, Master of Science, 2013 Directed By: Dr. Andrew Baldwin, Department of Environmental Science and Technology In recent decades the invasive plant Phragmites australis (common reed) has spread throughout Chesapeake Bay marshes, lowering plant community biodiversity. Excess nutrient loading and salinity intrusion due to sea-level rise make these marshes vulnerable to invasions. This study examined the interaction between Phragmites australis and the native Spartina cynosuroides (big cordgrass) to determine whether dominance of one species was detected across a range of salinity and nitrogen treatments. Aboveground biomass production of P. australis was greater than S. cynosuroides at lower salinities; however, S. cynosuroides maintained biomass production as salinity increased. Fv/Fm ratios were measured as an indirect measurement of plant tissue physiological health; only Spartina maintained the ratio at higher salinities. Nitrogen addition increased Phragmites biomass and Fv/Fm ratio at higher salinities. Results suggest salinity and nitrogen interactively affect Phragmites biomass production, and that the negative effect of increased salinity on Phragmites spread can be mitigated by nitrogen runoff. A COMPETITIVE INTERACTION AND DOMINANCE EXPERIMENT BETWEEN THE VEGETATIVE MARSH SPECIES PHRAGMITES AUSTRALIS AND SPARTINA CYNOSUROIDES UNDER ELEVATED SALINITY AND NITROGEN LEVELS
Effect of biomass burning over the western North Pacific Rim: wintertime maxima of anhydrosugars in ambient aerosols from Okinawa

Abstract. Biomass burning (BB) largely modifies the chemical composition of atmospheric aerosols on the globe. We collected aerosol samples (TSP) at Cape Hedo, on subtropical Okinawa Island, from October 2009 to February 2012 to study anhydrosugars as BB tracers. Levoglucosan was detected as the dominant anhydrosugar followed by its isomers, mannosan and galactosan. We found a clear seasonal trend of levoglucosan and mannosan with winter maxima and summer minima. Positive correlation was found between levoglucosan and nss-K+ (r = 0.38, p
Increased plasma S-adenosyl-homocysteine levels induce the proliferation and migration of VSMCs through an oxidative stress-ERK1/2 pathway in apoE(-/-) mice.

AIMS Although S-adenosyl-homocysteine (SAH) is considered to be a more sensitive predictor of cardiovascular disease than homocysteine, the underlying mechanisms of its effects remain unknown. We investigated the in vivo and in vitro effects of SAH on vascular smooth muscle cells (VSMCs) proliferation and migration related to the development of atherogenesis in apolipoprotein E-deficient (apoE(-/-)) mice. METHODS AND RESULTS A total of 72 apoE(-/-) mice were randomly divided into six groups (n= 12 for each group). The control group was fed a conventional diet, the M group was fed a 1% methionine-supplemented diet, the A group was fed a diet that was supplemented with the SAH hydrolase (SAHH) inhibitor adenosine-2, 3-dialdehyde (ADA), the M+A group was fed a diet that was supplemented with methionine plus ADA, and two of the groups were intravenously injected with retrovirus that expressed either SAHH shRNA (SAHH(+/-)) or scrambled shRNA semi-weekly for 8 weeks. Compared with the controls, the mice in the A, M+A, and SAHH(+/-) groups had higher plasma SAH levels, larger atheromatous plaques, elevated VSMC proliferation, and higher aortic reactive oxygen species and malondialdehyde levels. In cultured VSMCs, 5 μM ADA or SAHH shRNA caused SAH accumulation, which resulted in increased cell proliferation, migration, oxidative stress, and extracellular-regulated kinase 1/2 (ERK1/2) activation. These effects were significantly attenuated by preincubation with superoxide dismutase (300 U/mL). CONCLUSION Our results suggest that elevated SAH induces VSMC proliferation and migration through an oxidative stress-dependent activation of the ERK1/2 pathway to promote atherogenesis.