Miracle-dz/UniFAR-FTUs huggingface dataset:
Testing a New Analytic Model for Gravitational Lensing Probabilities

We study gravitational lensing with a multiple lens plane approach, proposing a simple analytical model for the probability density function (pdf) of the dark matter convergence, κ, for the different lens planes in a given cosmology as a function of redshift and smoothing angle, θ. The model is fixed solely by the variance of κ, which in turn is fixed by the amplitude of the power spectrum, σ8. We test the pdf against a high-resolution tree particle-mesh simulation and find that it is far superior to the Gaussian or the lognormal, especially for small values of θ ≪ 1′ and at large values of κ relevant to strong lensing. With this model, we predict the probabilities of strong lensing by a single plane or by multiple planes. We find that for θ ~ 10′′, a single plane accounts for almost all (~98%) of the strong-lensing cases for source redshift unity. However, for a more typical source redshift of 4, about 12% of the strong-lensing cases will result from the contribution of a secondary clump of matter along the line of sight, introducing a systematic error in the determination of the surface density of clusters, typically overestimating it by about 2%-5%. We also find that matter inhomogeneities introduce a dispersion in the value of the angular diameter distance about its cosmological mean. The probable error relative to the mean increases with redshift to a value of about 8% for z ≃ 6 and θ ~ 10′′.
Maintenance chemotherapy in non-small cell lung cancer.

The role of chemotherapy in patients with advanced non-smallcell lung cancer (NSCLC) has been established only in the lastdecade. The cornerstone is represented by the 1995 meta-analysis, which demonstrated the usefulness of platinum-basedchemotherapyinthissetting[1]. Inspiteoftheimprovedresultsof the last years using new drugs-combinations, chemotherapystill remains a palliative approach whose efﬁcacy has to bebalanced with its acute and cumulative toxicity. For thesereasons, the duration of the chemotherapeutic treatment isa ﬁeld of debate between clinical researchers and newchemotherapy strategies have been investigated, includingmaintenance chemotherapy.
Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis Published, JLR Papers in Press, March 1, 2007.

Ontogenic changes in the rat bile acid (BA) pool, measured enzymatically and by GC-MS, and expression of enzymes (5α-reductase, 5β-reductase, and cytochrome P450 enzymes Cyp7a1, Cyp8b1, Cyp27 and Cyp3a11), transporters [bile salt export pump, sodium taurocholate-cotransporting polypeptide, apical sodium-dependent bile acid transporter, and organic solute transporter α/β (Ostα/Ostβ)], and nuclear receptors [fetoprotein transcription factor (Ftf), farnesoid X receptor (Fxr), small heterodimer partner (Shp), and hepatic nuclear factor 4α (HNF-4α)], determined by quantitative PCR, were investigated. The absolute size of the BA pool increased progressively up to adulthood, whereas the complexity of its composition was high in fetuses, decreased after birth, increased again progressively up to adulthood, and decreased in aged animals. Allo-cholic acid only appeared early in development, in spite of low 5α-reductase expression. The relative size of the BA pool, corrected by liver weight, was maintained from 1 week after birth, except at weaning, when a transient peak accompanied by Shp downregulation and Cyp7a1 upregulation was observed. An imposed weaning delay of 1 week had no effect on the time course of the BA pool size but decreased the proportion of chenodeoxycholic and α-muricholic acids, whereas the proportion of cholic acid was increased, probably as a result of Cyp8b1 upregulation. In conclusion, changes in the expression of genes involved in BA homeostasis may play a role in physiological adaptations to digestive functions during the rat life span.
CerbB2 status in breast cancer: pathologic issues.

INTRODUCTION CerbB2 status determination in breast cancer is currently performed for predictive and prognostic information. However, much has yet to be learned about the accuracy, reproducibility and clinical correlation of the different testing methods available today. This is a review of the testing methods commonly in use and their applications in the management of breast cancer. METHODS A Medline search for review articles with keywords cerbB2, Her2 testing, immunohistochemistry (IHC), fluorescence in situ hybridisation (FISH) and breast cancer was done. Manual cross-referencing from the afore-mentioned articles and perusal of the package inserts, recommendations and manuals from the manufacturers of various commercially available test kits were also performed. RESULTS The 2 main methods of testing in use in most routine laboratories are IHC and FISH on formalin fixed, paraffin embedded, breast cancer tissue. There is no single, universally accepted method and the plethora of testing and interpretative protocols has confounded the issue of clinical correlation of cerbB2 status with outcome and patient selection for therapy. The current consensus in the literature is leaning towards FISH; however, as pointed out in this paper, the use of FISH as a routine test in most diagnostic laboratories is not yet a reality mainly due to cost, technical and manpower constraints. In this regard, IHC is by default the preferred choice in many routine laboratories. CONCLUSION Universal standardisation of testing methods for cerbB2 status determination, together with further clinical studies on the correlation of each method with outcome and response to therapy, will aid in the identification of the ideal method for stratifying patients with breast cancer into prognostic and optimal therapeutic groups.
The detection of disease clustering and a generalized regression approach.

The problem of identifying subtle time-space clustering of disease, as may be occurring in leukemia, is described and reviewed. Published approaches, generally associated with studies of leukemia, not dependent on knowledge of the underlying population for their validity, are directed towards identifying clustering by establishing a relationship between the temporal and the spatial separations for the n ( n - 1)/2 possible pairs which can be formed from the n observed cases of disease. Here it is proposed that statistical power can be improved by applying a reciprocal transform to these separations. While a permutational approach can give valid probability levels for any observed association, for reasons of practicability, it is suggested that the observed association be tested relative to its permutational variance. Formulas and computational procedures for doing so are given. While the distance measures between points represent symmetric relationships subject to mathematical and geometric regularities, the variance formula developed is appropriate for arbitrary relationships. Simplified procedures are given for the case of symmetric and skew-symmetric relationships. The general procedure is indicated as being potentially useful in other situations as, for example, the study of interpersonal relationships. Viewing the procedure as a regression approach, the possibility for extending it to nonlinear and multivariate situations is suggested. Other aspects of the problem and of the procedure developed are discussed. Similarly, pure temporal clustering can be identified by a study of incidence rates in periods of widespread epidemics. In point of fact, many epidemics of communicable diseases are somewhat local in nature and so these do actually constitute temporal-spatial clusters. For leukemia and similar diseases in which cases seem to arise substantially at random rather than as clear-cut epidemics, it is necessary to devise sensitive and efficient procedures for detecting any nonrandom component of disease occurrence. Various ingenious procedures which statisticians have developed for the detection of disease clustering are reviewed here. These procedures can be generalized so as to increase their statistical validity and efficiency. The technic to be given below for imparting statistical validity to the procedures already in vogue can be viewed as a generalized form of regression with possible useful application to problems arising in quite different contexts.
Redefining “dead on arrival”: Identifying the unsalvageable patient for the purpose of performance improvement

BACKGROUND Significant variation exists across registries in the criteria used to identify patients with no chance of survival, with potential for profound impact on trauma center mortality. The purpose of this study was to identify the optimal case definition for the unsalvageable patient, for the purpose of exclusion from performance improvement (PI) endeavors. METHODS Data were derived from the American College of Surgeons’ Trauma Quality Improvement Program for 2012 to 2013. We proposed three potential case definitions for the unsalvageable patient: (1) no signs of life as determined by local providers (NSOL), (2) prehospital cardiac arrest (PHCA), and (3) a proxy definition (PROXY) based on presenting vital signs, defined as emergency department (ED) heart rate = 0, ED systolic blood pressure = 0, and Glasgow Coma Scale score motor component = 1. Case definitions were compared using standard predictive tests to determine specificity and positive predictive value (PPV) for in-hospital mortality. After the optimal definition was identified, hierarchical logistic regression was used to assess the impact of including unsalvageable patients on trauma center risk-adjusted mortality. The impact on trauma center performance was determined as change in outlier status and performance decile after exclusion of patients who met the optimal case definition. RESULTS During the study period, 223,643 patients met inclusion criteria across 192 trauma centers. Overall in-hospital mortality was 7.2%. The PROXY definition had excellent PPV for death, with less than 1% of patients meeting the PROXY criterion surviving. By contrast, NSOL and PHCA had PPVs low enough such that many of these patients went on to live (33% and 10%, respectively). After exclusion of patients who met the PROXY definition, 7% of trauma centers changed performance decile. This change was greatest for patients with penetrating injury and shock, with change in performance decile at 23% and 33% of centers, respectively. CONCLUSION The PROXY case definition has excellent predictive utility to identify patients who, based on presenting vital signs, will go on to die. PROXY should be used to exclude unsalvageable patients from PI endeavors.
Adult reformulations of child errors as negative evidence

Parents frequently check up on what their children mean. They often do this by reformulating with a side sequence or an embedded correction what they think their children said. These reformulations effectively provide children with the conventional form for that meaning. Since the child's utterance and the adult reformulation differ while the intended meanings are the same, children infer that adults are offering a correction. In this way, reformulations identify the locus of any error, and hence the error itself. Analyses of longitudinal data from five children between 2;0 and 4;0 (three acquiring English and two acquiring French) show that (a) adults reformulate their children's erroneous utterances and do so significantly more often than they replay or repeat error-free utterances; (b) their rates of reformulation are similar across error-types (phonological, morphological, lexical, and syntactic) in both languages; (c) they reformulate significantly more often to younger children, who make more errors. Evidence that children attend to reformulations comes from four measures: (a) their explicit repeats of corrected elements in their next turn; (b) their acknowledgements (yeah or uh-huh) as a preface to their next turn; (c) repeats of any new information included in the reformulation; and (d) their explicit rejections of reformulations where the adult has misunderstood. Adult reformulations, then, offer children an important source of information about how to correct errors in the course of acquisition.
Linear Massive MIMO Precoders in the Presence of Phase Noise—A Large-Scale Analysis

We study the impact of phase noise on the downlink performance of a multiuser multiple-input-multiple-output (MIMO) system, where the base station (BS) employs a large number of transmit antennas M. We consider a setup where the BS employs Mosc free-running oscillators, and M/Mosc antennas are connected to each oscillator. For this configuration, we analyze the impact of phase noise on the performance of zero forcing (ZF), regularized ZF, and matched filter precoders when M and the number of users K are asymptotically large, whereas the ratio M/K = β is fixed. We analytically show that the impact of phase noise on the signal-to-interference-plus-noise ratio (SINR) can be quantified as an effective reduction in the quality of the channel state information (CSI) available at the BS when compared with a system without phase noise. As a consequence, we observe that as Mosc increases, the SINR performance of all considered precoders degrades. On the other hand, the variance of the random phase variations caused by the BS oscillators reduces with increasing Mosc. Through Monte Carlo simulations, we verify our analytical results and compare the performance of the precoders for different phase noise and channel noise variances. For all considered precoders, we show that when β is small, the performance of the setup where all BS antennas are connected to a single oscillator is superior to that of the setup where each BS antenna has its own oscillator. However, the opposite is true when β is large and the signal-to-noise ratio (SNR) at the users is low.
Pharmacokinetics of the infusion of alfentanil in man.

The pharmacokinetics of alfentanil under the conditions of an empirically derived 1-h continuous infusion of 3 micrograms kg-1 min-1, with a bolus of 80 micrograms kg-1, both i.v. , were determined in five patients. The distribution half-life (mean +/- SD) (7.4 +/- 3.1 min), elimination half-life (86.7 +/- 15.8 min), apparent volume of distribution, Varea (0.44 +/- 0.15 litre kg-1) and elimination clearance (3.33 +/- 0.75 ml kg-1 min-1) were similar to those previously reported for a single bolus of alfentanil. These values for apparent volume of distribution and clearance can be used to calculate correct bolus and infusion doses to maintain any desired steady state plasma concentration using standard formulae: for example, to maintain a steady state plasma concentration of 400 ng ml-1, a bolus dose of 176 micrograms kg-1 and an infusion of 1.3 micrograms kg-1 min1 would be required.
Unintended Consequences of the Market Risk Requirement in Banking Regulation

We analyze a bank that operates under the Basel credit and market risk requirements, and that maximizes its value through recapitalizations, dividends, and liquid asset investments. According to our model, the market risk requirement may postpone recapitalization and this way increase the bank’s default probability. We show that this is indeed the case if the expected return and volatility of the liquid asset portfolio are high, i.e., then the market risk requirement raises the default probability of the bank. In this sense the market risk requirement is inefficient.
Tunable multiwavelength Brillouin-erbium fiber laser with a polarization-maintaining fiber Sagnac loop filter

We demonstrate the generation of 12-wavelength comb with 14.5-nm tunable range in the Brillouin-Erbium fiber laser. This is achieved through tuning the gain profile of Erbium-doped fiber by a Sagnac loop filter with 18-cm polarization-maintaining fiber, in conjunction with modifying the wavelength of Brillouin pump. The experiment also demonstrates that the tunable range is closely equal to the 3-dB bandwidth of Sagnac loop filter due to its periodic transmission profile. Meanwhile, the effect of the 980-nm pump on the tunable multiwavelength generation is investigated. The power of 980-nm pump has a great effect on the wavelength number and the output power of the generated multiwavelength comb, but little on the tunable range. This technique may be applicable to multiwavelength operation lasers with a large tunable range.
Clinical Importance of the Lateral Branch of the Deep Peroneal Nerve

Persistent recalcitrant dorsolateral foot pain after ankle sprain cannot always be explained by known anatomic nerve pathways. To determine whether an impingement of a lateral branch of the deep peroneal nerve might be responsible for atypical pain, we conducted a cadaveric anatomic study to identify the anatomy and course of the nerve. Furthermore, using this information, we conducted a clinical study to determine if targeted treatment to a lateral branch of the deep peroneal nerve would resolve these symptoms. We dissected 22 cadaveric feet to identify a large lateral branch of the deep peroneal nerve. This nerve arborized into five main branches. We identified two areas of compression in the lateral branch of the deep peroneal nerve. We also performed a prospective clinical study including 11 consecutive patients with a 1-year minimum followup. Pain and clinical findings corresponded to the anatomic compression sites in all 11 patients. All patients responded to a local anesthetic injection or surgical release of the lateral branch of the deep peroneal nerve. We identified a previously unreported complex course of the lateral branch of the deep peroneal nerve that correlated with clinical impingement syndrome and responded to specifically targeted treatment.Level of Evidence: Level II, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.
Socially Maladjusted Adolescents' Perceptions of Their Families

The Family Environment Scale, a 90-item true-false instrument used to evaluate the social climate of families, was administered to 17 socially maladjusted adolescents. The results showed that these adolescents perceived their families as not highly supportive or concerned about each member's welfare. These families were perceived as providing little cultural, intellectual or recreational stimulation in the home. The families scored relatively higher on the Conflict subscale which measures the extent to which open expression of anger and aggression are characteristic of the family. Implications of these data for understanding and programming for the socially maladjusted child were discussed. Also the clinical and educational utility, e.g., structuring counseling sessions, planning home visits, of the scale was delineated.
Expansion of Genotypic Diversity and Establishment of 2009 H1N1 Pandemic-Origin Internal Genes in Pigs in China

ABSTRACT Two-way transmission of influenza viruses between humans and swine has been frequently observed, and the occurrence of the 2009 H1N1 pandemic influenza virus (pdm/09) demonstrated that swine-origin viruses could facilitate the genesis of a pandemic strain. Although multiple introductions to and reassortment in swine of the pdm/09 virus have been repeatedly reported in both Eurasia and the Americas, its long-term impact on the development of swine influenza viruses (SIVs) has not been systematically explored. Our comprehensive evolutionary studies of the complete genomes of 387 SIVs obtained from 2009 to 2012 by influenza virus surveillance in China revealed 17 reassortant genotypes with pdm/09-origin genes. Even though the entire 2009 pandemic virus and its surface genes cannot persist, its internal genes have become established and are now the predominant lineages in pigs in the region. The main persistent pdm/09-origin reassortant forms had at least five pdm/09-origin internal genes, and their surface genes were primarily of European avian-like (EA) or human H3N2-like SIV origin. These findings represent a marked change in the evolutionary patterns and ecosystem of SIVs in China. It is possible that the pdm/09-origin internal genes are in the process of replacing EA or triple-reassortant-like internal genes. These alterations in the SIV gene pool need to be continually monitored to assess changes in the potential for SIV transmission to humans. IMPORTANCE Shortly after the emergence of the 2009 pandemic H1N1 (pdm/09) influenza virus, it was transmitted from humans to pigs and this continues to occur around the world. Many reassortants between pdm/09-origin viruses and enzootic swine influenza viruses (SIVs) have been detected. However, the long-term impact of pdm/09-origin viruses on the SIV gene pool, which could lead to the generation of influenza viruses with the potential to infect humans, has not been systematically examined. From extensive surveillance of SIVs over a 38-month period in southern China, it was found that although neither complete pdm/09 viruses nor their surface genes could persist in pigs, their internal genes did persist. Over the survey period, these internal genes became predominant, potentially replacing those of the enzootic SIV lineages. The altered diversity of the SIV gene pool needs to be closely monitored for changes in the potential for SIV transmission to humans.
Drukčiji matematički model za sklop tranzistorskog pretvarača (chopper-a)

Original scientific paper Abstract: In this study, dc-dc boost converter circuit is described as transformer circuit for direct form of energy in the electrical machine driver system of electrical and electronic engineering. First, mathematical equations of the converter circuit are created when circuit switch opened and closed controlling two states. Then, the equations are resolved for common equation so that the state space equation is formed in matrix form. A mathematical model of the converter circuit is performed at the Matlab Simulink.
First-order anharmonic correction to the free energy of a Coulomb crystal in periodic boundary conditions.

The free energy of the classical one-component plasma is calculated analytically in the crystalline phase for both fcc and bcc lattices to 0( T'), where T is the temperature. By application of thermodynamic perturbation theory, we explicitly evaluate the effect of three- and four-phonon interactions on the partition function. Periodic boundary conditions are applied to make contact with previous numerical work, in which the O(T ) term was assumed to be negligible. We find that it is much larger than previously thought. This increases the thermodynamic stability of the crystal phase over previous estimates.
Pictures or questions?: examining user responses to association-based authentication

Challenge questions are commonly used as a backup should users forget their "main" authentication secret. Such questions are notoriously difficult to design properly, and have sometimes allowed intruders to access the system via a back door simply by engaging in some online research about the victim [33]. Most challenge questions rely on a user's knowledge of their early life, something which tends not to deteriorate over time [15]. Unfortunately, this kind of information can also be discovered by a determined attacker. We developed a challenge protocol in which a set of pictorial cues are used to prompt answers, rather than using the standard mechanism based on textual questions. The prompts solicit associative memories that need not represent factual information (information that aids an attacker in mounting targeted observation attacks) and serve as a stronger cue to aid the recall. Our results reveal that the solution has comparable security with that of traditional challenge questions (when considering external attackers), and suggests additional benefits from posing three or more questions serially. Furthermore, we obtained a 13% increase in the memorability of our (name-based) answers, while our results suggest enhancements could help improve the recall of place-based answers. We conclude by discussing how further modifications could achieve gains on the usability front.