Miracle-dz/UniFAR-FTUs huggingface dataset:
A study of DRAM failures in the field

Most modern computer systems use dynamic random access memory (DRAM) as a main memory store. Recent publications have confirmed that DRAM errors are a common source of failures in the field. Therefore, further attention to the faults experienced by DRAM sub-systems is warranted. In this paper, we present a study of 11 months of DRAM errors in a large high-performance computing cluster. Our goal is to understand the failure modes, rates, and fault types experienced by DRAM in production settings. We identify several unique DRAM failure modes, including single-bit, multi-bit, and multi-chip failures. We also provide a deterministic bound on the rate of transient faults in the DRAM array, by exploiting the presence of a hardware scrubber on our nodes. We draw several conclusions from our study. First, DRAM failures are dominated by permanent, rather than transient, faults, although not to the extent found by previous publications. Second, DRAMs are susceptible to large multi-bit failures, such as failures that affect an entire DRAM row or column, indicating faults in shared internal circuitry. Third, we identify a DRAM failure mode that disrupts access to other DRAM devices that share the same board-level circuitry. Finally, we find that chipkill error-correcting codes (ECC) are extremely effective, reducing the node failure rate from uncorrected DRAM errors by 42x compared to single-error correct/double-error detect (SEC-DED) ECC.
On the Theoretical Foundations of Research into the Understandability of Business Process Models

Against the background of the growing significance of Business Process Management (BPM) for Information Systems (IS) research and practice, especially the field of Business Process Modeling gains more and more importance. Business process models support communication about as well as the coordination of processes and have become a widely adopted tool in practice. As the understandability of business process models plays a crucial role in communication processes, more and more studies on process model understandability have been conducted in IS research. This article aims at investigating underlying theories of research into business process model understandability by means of an in-depth analysis of 126 systematically retrieved research articles on the topic. It shows in how far process model understandability research is multi-theoretically founded. Identified theories differ regarding addressed subject matters, their coverage, their focus as well as the underlying notion of model understanding, which is exemplarily demonstrated and discussed in this article. Moreover, implications of the findings are discussed and an outlook on future business process model understandability research and on the integration potential of theories in this field is given.
Acquired Protective Immunity in Atlantic Salmon Salmo salar against the Myxozoan Kudoa thyrsites Involves Induction of MHIIβ+ CD83+ Antigen-Presenting Cells

ABSTRACT The histozoic myxozoan parasite Kudoa thyrsites causes postmortem myoliquefaction and is responsible for economic losses to salmon aquaculture in the Pacific Northwest. Despite its importance, little is known about the host-parasite relationship, including the host response to infection. The present work sought to characterize the immune response in Atlantic salmon during infection, recovery, and reexposure to K. thyrsites. After exposure to infective seawater, infected and uninfected smolts were sampled three times over 4,275 degree-days. Histological analysis revealed infection severity decreased over time in exposed fish, while in controls there was no evidence of infection. Following a secondary exposure of all fish, severity of infection in the controls was similar to that measured in exposed fish at the first sampling time but was significantly reduced in reexposed fish, suggesting the acquisition of protective immunity. Using immunohistochemistry, we detected a population of MHIIβ+ cells in infected muscle that followed a pattern of abundance concordant with parasite prevalence. Infiltration of these cells into infected myocytes preceded destruction of the plasmodium and dissemination of myxospores. Dual labeling indicated a majority of these cells were CD83+/MHIIβ+. Using reverse transcription-quantitative PCR, we detected significant induction of cellular effectors, including macrophage/dendritic cells (mhii/cd83/mcsf), B cells (igm/igt), and cytotoxic T cells (cd8/nkl), in the musculature of infected fish. These data support a role for cellular effectors such as antigen-presenting cells (monocyte/macrophage and dendritic cells) along with B and T cells in the acquired protective immune response of Atlantic salmon against K. thyrsites.
Prevalence and determinants of one month hand pain and hand related disability in the elderly (Rotterdam study)

Objective: To study the prevalence of hand pain and hand disability in an open population, and the contribution of their potential determinants. Methods: Baseline data were used from 7983 participants in the Rotterdam study (a population based study in people aged ⩾55 years). A home interview was used to determine the presence of hand pain during the previous month, rheumatoid arthritis, osteoarthritis in any joint, diabetes, stroke, thyroid disease, neck/shoulder pain, gout, history of fracture in the past five years, and Parkinson’s disease, as well as age, sex, and occupation. Hand disability was defined as the mean score of eight questions related to hand function. Body mass index was measured and hand x rays were taken. Results: The one month period prevalence of hand pain was 16.9%. The prevalence of hand disability was 13.6%. In univariate analysis for hand pain, rheumatoid arthritis had the highest explained variance (R2) and odds ratio. For hand disability, aging showed the highest explained variance and Parkinson’s disease had the highest odds ratio. All determinants together showed an explained variance of 19.8% for hand pain and 25.2% for hand disability. In multivariate analysis, positive radiographic hand osteoarthritis was a poor explanation for hand pain (R2 = 0.5%) or hand disability (R2 = 0). Conclusions: The contribution of available potential determinants in this study was about 20% for hand pain and 25% for hand disability in an unselected population of elderly people. Thus a greater part of hand pain/hand disability remains unexplained.
Measuring “Awareness of Environmental Consequences”: Two Scales and Two Interpretations

Moderate or poor reliabilities, worrisome correlation patterns and ambiguous dimensionality raise questions about the awareness of consequences scale being a valid measure of egoistic, social-altruistic and biospheric value orientations. These results may, however, indicate something else. An exploratory analysis performed on three samples collected from the general public provides evidence for a reinterpretation of the scale. We believe the concepts of egoistic, social and biospheric value orientations remain important as a potential explanation of behaviour. However, our results imply that whether people cognitively organise their beliefs in this way when considering adverse environmental consequences requires a different approach from the current awareness of consequences scale. The evidence shows the current scale must be reinterpreted as a measure of concern over the positive and negative consequences of environmental action and inaction.
Ciclesonide reduces the need for oral steroid use in adult patients with severe, persistent asthma.

STUDY OBJECTIVES Oral corticosteroids (OCS) may be associated with systemic adverse events (AEs), which can be reduced by replacing OCS with inhaled corticosteroids (ICS). The potential of ciclesonide, a novel ICS, to reduce OCS use in patients with severe, persistent asthma was evaluated in this study. DESIGN A phase III, 12-week, international, multicenter, double-blind, placebo-controlled, parallel-group study. PATIENTS Adult and adolescent patients (> or = 12 years old; n = 141) with severe, persistent, oral steroid (prednisone)-dependent asthma. INTERVENTIONS Patients were randomized to receive ciclesonide (640 mug/d or 1,280 microg/d [ex-actuator]) bid or placebo for 12 weeks. Weekly evaluations determined eligibility for prednisone dose reduction based on predetermined criteria. MEASUREMENTS AND RESULTS The prednisone dose was significantly reduced by 47% and 63% in the groups receiving ciclesonide, 640 microg/d, and ciclesonide, 1,280 microg/d, respectively, vs an increase of 4% in the placebo group (both p < or = 0.0003) at week 12. By week 12, prednisone was discontinued by approximately 30% of patients in the ciclesonide-treated groups, vs 11% of patients in the placebo group (both p < or = 0.04). FEV1 improved significantly at week 12 in the ciclesonide treatment groups vs placebo (p < 0.03). The occurrence of local and systemic AEs was comparable between all treatment groups. CONCLUSION Study results suggest that ciclesonide significantly reduces the need for OCS in patients with severe, persistent asthma, while maintaining asthma control.
Lipid factor (bVLF) from bovine vitreous body evokes in EGFR‐T17 cells a Ca2+‐dependent K+ current associated with inositol 1,4,5‐trisphosphate‐independent Ca2+ mobilization

Bovine vitreous lipid factor (bVLF) is a complex phospholipid isolated from bovine vitreous body with strong Ca2+‐mobilizing activity. In this study, the effects of bVLF on membrane potential were investigated in EGFR‐T17 fibroblasts with the whole‐cell patch clamp technique on monolayer cells, as well as with the fluorescent dye bis‐oxonol as membrane potential‐sensitive probe on monolayer and suspension cells. bVLF induced a transient hyperpolarization characterized by an initial peak and subsequent return to resting membrane potential levels within 1–2 min. The increase of [Ca2+]i was concomitant with an outward current responsible for the hyperpolarizing response. Results with: (a) high [K+]o media; (b) the monovalent cation ionophore gramicidin; and (c) substitution of K+ with Cs+ in the intracellular solution were consistent with the involvement of K+ channels. The bVLF‐induced hyperpolarization was blocked by the K+ channel blockers, quinine and tetraethylamonium chloride, and partially affected by 4‐aminopyridine. The calcium ionophore ionomycin caused a similar hyperpolarization as bVLF. When intracellular calcium was buffered by adding BAPTA to the pipette solution, bVLF‐activated outward current was prevented. Moreover, the hyperpolarization response was strongly reduced at low doses (3 nM) of specific Ca2+‐activated K+ channel blockers, charybdotoxin and iberiotoxin. Based on these observations we conclude that bVLF hyperpolarizes the cells via the activation of a Ca2+‐dependent K+ current. In addition, it was observed that bVLF did not have a significant effect on intercellular communication measured by a single patch‐electrode technique. Thus, membrane potential changes appeared to belong to the earliest cellular responses triggered by bVLF, and are closely associated with phosphatidic acid‐dependent [Ca2+]i mobilization. © 2003 Wiley‐Liss, Inc.
Pooled analysis of genome-wide association studies of cervical intraepithelial neoplasia 3 (CIN3) identifies a new susceptibility locus

Recent genome-wide association studies (GWASs) in subjects of European descent have identified associations between cervical cancer risk and three independent loci as well as multiple classical human leukocyte antigen (HLA) alleles at 6p21.3. To search for novel loci associated with development of cervical cancer, we performed a pooled analysis of data from two GWASs by imputing over 10 million genetic variants and 424 classical HLA alleles, for 1,553 intraepithelial neoplasia 3 (CIN3), 81 cervical cancer and 4,442 controls from the Swedish population. Notable findings were validated in an independent study of 961 patients (827 with CIN3 and 123 with cervical cancer) and 1,725 controls. Our data provided increased support for previously identified loci at 6p21.3 (rs9271898, P = 1.2 × 10−24; rs2516448, 1.1 × 10−15; and rs3130196, 2.3 × 10−9, respectively) and also confirmed associations with reported classical HLA alleles including HLA-B*07:02, -B*15:01, -DRB1*13:01, -DRB1*15:01, -DQA1*01:03, -DQB1*06:03 and -DQB1*06:02. In addition, we identified and subsequently replicated an independent signal at rs73730372 at 6p21.3 (odds ratio = 0.60, 95% confidence interval = 0.54–0.67, P = 3.0 × 10−19), which was found to be an expression quantitative trait locus (eQTL) of both HLA-DQA1 and HLA-DQB1. This is one of the strongest common genetic protective variants identified so far for CIN3. We also found HLA-C*07:02 to be associated with risk of CIN3. The present study provides new insights into pathogenesis of CIN3.
Counseling Troubled Older Adults: A Handbook for Pastors and Religious Caregivers

Counseling Troubled Older Adults is designed as a pastoral care textbook for use in theological seminaries and by ministers engaged in pastoral ministry with older persons. By providing this handbook for pastors and other religious caregivers, Koenig and Weaver provide a resource that will help improve the clinical skills of caregivers in working with older persons with symptoms of mental illnesses. It will inform clergy of the most recent research on how older people draw upon their faith to cope with crises.
Previous Trauma Exposure and PTSD Symptoms as Predictors of Subjective and Biological Response to Stress

Objective: The immediate and long-term effects of traumatic exposure and subsequent posttraumatic stress reactions in people in high-risk occupations are well-documented. What is less evident is the impact of this traumatic exposure and subsequent traumatic stress symptoms on workers' response to acute stress situations. This study aimed to examine the association between prior traumatic exposure related to policing, current posttraumatic stress symptoms and biological markers of stress, and subjective appraisal of stress before, during, and after exposure to acutely stressful stimuli. Method: A stressful policing situation was created through the use of a video simulator room. Participants' responses to the simulated emergency were evaluated by monitoring heart rate, collecting salivatory samples for cortisol analysis, and repeated administration of a subjective measure of anxiety. Results: Biological indicators of stress, as measured by cortisol level and heart rate, were not associated with previous trauma exposure or trauma symptoms; however, biological response was associated with subjective anxiety. Vulnerability to psychological stress responses during an acute stress situation was also associated with lower levels of social support, previous traumatic exposures, and preexisting symptoms of traumatic stress. The importance of these factors became more pronounced as time progressed after the event. Conclusion: Previous trauma exposure did not put individuals at increased risk of biological distress during an acute stress situation. However, previous trauma and reduced social supports were associated with continuing psychological distress, confirming previous research and raising concerns about the cumulative negative effects of traumatic exposure on psychological health in emergency responders.
The complexity of relational query languages (Extended Abstract)

Two complexity measures for query languages are proposed. Data complexity is the complexity of evaluating a query in the language as a function of the size of the database, and expression complexity is the complexity of evaluating a query in the language as a function of the size of the expression defining the query. We study the data and expression complexity of logical languages - relational calculus and its extensions by transitive closure, fixpoint and second order existential quantification - and algebraic languages - relational algebra and its extensions by bounded and unbounded looping. The pattern which will be shown is that the expression complexity of the investigated languages is one exponential higher then their data complexity, and for both types of complexity we show completeness in some complexity class.
Scalable Producing Embryoid Bodies by Rotary Cell Culture System and Constructing Engineered Cardiac Tissue with ES‐Derived Cardiomyocytes in Vitro

Embryonic stem (ES) cells are of significant interest either as an in vitro model recapitulating early embryonic development or as a renewable source of therapeutically useful cells. ES cells aggregation is important for embryoid bodies (EBs) formation and the subsequent generation of ES cell derivatives. This study was conducted to describe scalable production of EBs by the rotary cell culture system (RCCS, STLV type) and estimate the feasibility of constructing engineered cardiac tissue (ECT). In comparison with suspension culture in a Petri dish, the efficiency of the dynamic process was analyzed with respect to the yield of EB formation and their cardiomyocyte differentiation. Cardiomyocyte differentiation was evaluated by immunohistochemical analysis. After the elementary enrichment by gradient percoll, ES cell‐derived cardiomyocytes were applied to construct ECT. Cell gross morphology, spatial distribution, and ultrastructure were evaluated by using histological analysis, confocal laser scanning microscopy, and transmission electron microscopy. Results showed that EB efficiencies in STLV were nearly 1.5–2.0 times higher than that of liquid suspension cultures, and cardiomyocyte differentiation of EBs progressed in a normal course after the dynamic cultivation in STLV. Additionally, the differentiated cultures could be enriched elementarily by gradient percoll. Once cast into the collagen strand, cells grew well and became more matured in Petri dishes. Synchronous contraction of the cell cluster was observed on the surface of the ECT, and cell connection was also established. It was the first report to have beating ES‐derived cardiomyocytes on a 3‐D collagen scaffold, which might provide a promising model for physiological and pharmacological studies and tissue replacement therapy.
Pseudomonas fluorescens Transportome Is Linked to Strain-Specific Plant Growth Promotion in Aspen Seedlings under Nutrient Stress

Diverse communities of bacteria colonize plant roots and the rhizosphere. Many of these rhizobacteria are symbionts and provide plant growth promotion (PGP) services, protecting the plant from biotic and abiotic stresses and increasing plant productivity by providing access to nutrients that would otherwise be unavailable to roots. In return, these symbiotic bacteria receive photosynthetically-derived carbon (C), in the form of sugars and organic acids, from plant root exudates. PGP activities have been characterized for a variety of forest tree species and are important in C cycling and sequestration in terrestrial ecosystems. The molecular mechanisms of these PGP activities, however, are less well-known. In a previous analysis of Pseudomonas genomes, we found that the bacterial transportome, the aggregate activity of a bacteria's transmembrane transporters, was most predictive for the ecological niche of Pseudomonads in the rhizosphere. Here, we used Populus tremuloides Michx. (trembling aspen) seedlings inoculated with one of three Pseudomonas fluorescens strains (Pf0-1, SBW25, and WH6) and one Pseudomonas protegens (Pf-5) as a laboratory model to further investigate the relationships between the predicted transportomic capacity of a bacterial strain and its observed PGP effects in laboratory cultures. Conditions of low nitrogen (N) or low phosphorus (P) availability and the corresponding replete media conditions were investigated. We measured phenotypic and biochemical parameters of P. tremuloides seedlings and correlated P. fluorescens strain-specific transportomic capacities with P. tremuloides seedling phenotype to predict the strain and nutrient environment-specific transporter functions that lead to experimentally observed, strain, and media-specific PGP activities and the capacity to protect plants against nutrient stress. These predicted transportomic functions fall in three groups: (i) transport of compounds that modulate aspen seedling root architecture, (ii) transport of compounds that help to mobilize nutrients for aspen roots, and (iii) transporters that enable bacterial acquisition of C sources from seedling root exudates. These predictions point to specific molecular mechanisms of PGP activities that can be directly tested through future, hypothesis-driven biological experiments.
Androgen Receptor CAG Repeat Length and Risk of Biliary Tract Cancer and Stones

Biliary tract cancers, encompassing cancers of the gallbladder, extrahepatic bile ducts, and ampulla of Vater, are rare but highly fatal. Gallstones represent the major risk factor for biliary tract cancer, and share with gallbladder cancer a female predominance and an association with reproductive factors and obesity. Although estrogens have been implicated in earlier studies of gallbladder cancer, there are no data on the role of androgens. Because intracellular androgen activity is mediated through the androgen receptor (AR), we examined associations between AR CAG repeat length [(CAG)n] and the risk of biliary tract cancers and stones in a population-based study of 331 incident cancer cases, 837 gallstone cases, and 750 controls from Shanghai, China, where the incidence rates for biliary tract cancer are rising sharply. Men with (CAG)n >24 had a significant 2-fold risk of gallbladder cancer [odds ratio (OR), 2.00; 95% confidence interval (CI), 1.07-3.73], relative to those with (CAG)n ≤ 22. In contrast, women with (CAG)n >24 had reduced gallbladder cancer risk (OR, 0.69; 95% CI, 0.43-1.09) relative to those with (CAG)n ≤ 22; P interaction sex = 0.01, which was most pronounced for women ages 68 to 74 (OR, 0.48; 95% CI, 0.25-0.93; P interaction age = 0.02). No associations were found for bile duct cancer or gallstones. Reasons for the heterogeneity of genetic effects by gender and age are unclear but may reflect an interplay between AR and the levels of androgen as well as estrogen in men and older women. Further studies are needed to confirm these findings and clarify the mechanisms involved. Cancer Epidemiol Biomarkers Prev; 19(3); 787–93