Miracle-dz/UniFAR-FTUs huggingface dataset:
Decisions to Withhold Diagnostic Investigations in Nursing Home Patients with a Clinical Suspicion of Venous Thromboembolism

Background This study aimed to gather insights in physicians' considerations for decisions to either refer for- or to withhold additional diagnostic investigations in nursing home patients with a suspicion of venous thromboembolism. Methods Our study was nested in an observational study on diagnostic strategies for suspected venous thromboembolism in nursing home patients. Patient characteristics, bleeding-complications and mortality were related to the decision to withhold investigations. For a better understanding of the physicians' decisions, 21 individual face-to-face in-depth interviews were performed and analysed using the grounded theory approach. Results Referal for additional diagnostic investigations was forgone in 126/322 (39.1%) patients with an indication for diagnostic work-up. ‘Blind’ anticoagulant treatment was initiated in 95 (75.4%) of these patients. The 3month mortality rates were higher for patients in whom investigations were withheld than in the referred patients, irrespective of anticoagulant treatment (odds ratio 2.45; 95% confidence interval 1.40 to 4.29) but when adjusted for the probability of being referred (i.e. the propensity score), there was no relation of non-diagnosis decisions to mortality (odds ratio 1.75; 0.98 to 3.11). In their decisions to forgo diagnostic investigations, physicians incorporated the estimated relative impact of the potential disease; the potential net-benefits of diagnostic investigations and whether performing investigations agreed with established management goals in advance care planning. Conclusion Referral for additional diagnostic investigations is withheld in almost 40% of Dutch nursing home patients with suspected venous thromboembolism and an indication for diagnostic work-up. We propose that, given the complexity of these decisions and the uncertainty regarding their indirect effects on patient outcome, more attention should be focused on the decision to either use or withhold additional diagnostic tests.
Shared Decision-Making: Increases Autonomy in Substance-Dependent Patients

This study examines the effect of a shared decision-making intervention (SDMI) on patients’ and clinicians’ self-perceived interpersonal behavior. Clinicians (n = 34) in three addiction treatment centers in the Netherlands were randomly assigned to SDMI or treatment decision-making as usual. Patients receiving inpatient treatment in 2005–2006 were included (n = 212). Baseline characteristics were measured by the European Addiction Severity Index (EuropASI) and the Composite International Diagnostic Interview—Substance Abuse Module (CIDI-SAM). Treatment goals were assessed using the Goals of Treatment Questionnaire (GoT-Q) plus a Q-sort ranking procedure. Interpersonal behavior was measured by Interpersonal Checklist—Revised (ICL-R) at baseline, end of treatment, and 3-month follow-up. Repeated measures analyses of variance and multiple hierarchical linear regression analysis were used. The key finding of this study was that SDMI is associated with an increase of patient autonomy (independent behavior) and control behavior. The study limitations have been noted.
The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane

Without the protein TMED7, the immune receptor TLR4 cannot reach the cell surface but exhibits ligand-independent signaling from the inside. Traffic Cop for an Immune Receptor Toll-like receptor 4 (TLR4) is a cell surface receptor that recognizes the bacterial product lipopolysaccharide (LPS) and stimulates an inflammatory response. However, after binding extracellular LPS, TLR4 is internalized and activates a different signaling pathway. Liaunardy-Jopeace et al. found that the adaptor protein TMED7 directed the movement of TLR4 in the other direction—from intracellular sites of synthesis to the cell membrane. Disrupting this process not only blocked TLR4 from appearing at the cell surface but also produced low-level, ligand-independent signaling from the accumulated internal receptors. Toll-like receptor 4 (TLR4), the receptor for the bacterial product endotoxin, is subject to multiple points of regulation at the levels of signaling, biogenesis, and trafficking. Dysregulation of TLR4 signaling can cause serious inflammatory diseases, such as sepsis. We found that the p24 family protein TMED7 (transmembrane emp24 protein transport domain containing 7) is required for the trafficking of TLR4 from the endoplasmic reticulum to the cell surface through the Golgi. TMED7 formed a stable complex with the ectodomain of TLR4, an interaction that required the coiled-coil and Golgi dynamics (GOLD) domains, but not the cytosolic, coat protein complex II (COP II) sorting motif, of TMED7. Depletion of TMED7 reduced TLR4 signaling mediated by the adaptor protein MyD88 (myeloid differentiation marker 88), but not that mediated by the adaptor proteins TRIF [Toll–interleukin-1 receptor (TIR) domain–containing adaptor protein inducing interferon-β] and TRAM (TRIF-related adaptor molecule). Truncated forms of TMED7 lacking the COP II sorting motif or the transmembrane domain were mislocalized and resulted in ligand-independent signaling that probably arises from receptors accumulated intracellularly. Together, these results support the hypothesis that p24 proteins perform a quality control step by recognizing correctly folded anterograde cargo, such as TLR4, in early secretory compartments and facilitating the translocation of this cargo to the cell surface.
The Impact of Employer Branding on Employees: The Role of Employment Offering in the Prediction of Their Affective Commitment

Most studies dedicated to the examination of employer branding in industrial/organisational psychology investigated it using samples of applicants. The objective of the present research was to study the influence of the employer branding of a company on its employees’ attitudes. More precisely, we examined the interactive effect of the employment offering as portrayed by organisational communications and the employment experience as lived by employees on their affective commitment (AC). Furthermore, we analysed the mechanisms underlying these relationships, i.e. perceived organisational support (POS) and psychological contract violation (PCV). One-hundred eighty-six department managers of a large multinational retailing company involved in employer branding practices were surveyed. Results indicated that employment offering and lived employment experience interact in the prediction of both POS and PCV and this interactive effect carries over to AC. Implications of these findings for both researchers and practitioners are discussed.
Signal convergence in fruits: a result of selection by frugivores?

The Dispersal Syndrome hypothesis remains contentious, stating that apparently nonrandom associations of fruit characteristics result from selection by seed dispersers. We examine a key assumption under this hypothesis, i.e. that fruit traits can be used as reliable signals by frugivores. We first test this assumption by looking at whether fruit colour allows birds and primates to distinguish between fruits commonly dispersed by birds or primates. Second, we test whether the colours of fruits dispersed by primates are more contrasting to primates than the colours of bird‐dispersed fruits, expected if fruit colour is an adaptation to facilitate the detection by seed dispersers. Third, we test whether fruit colour has converged in unrelated plant species dispersed by similar frugivores. We use vision models based on peak sensitivities of birds’ and primates’ cone cells. We base our analyses on the visual systems of two types of birds (violet and ultraviolet based) and three types of primates (trichromatic primates from the Old and the New Worlds, and a dichromatic New World monkey). Using a Discriminant Function Analysis, we find that all frugivore groups can reliably discriminate between bird‐ and primate‐dispersed fruits. Fruit colour can be a reliable signal to different seed dispersers. However, the colours of primate‐dispersed fruits are less contrasting to primates than those of bird‐dispersed fruits. Fruit colour convergence in unrelated plants is independent of phylogeny and can be better explained by disperser type, which supports the hypothesis that frugivores are important in fruit evolution. We discuss adaptive and nonadaptive hypotheses that can potentially explain the pattern we found.
Multiple Origins of the Pathogenic Yeast Candida orthopsilosis by Separate Hybridizations between Two Parental Species

Mating between different species produces hybrids that are usually asexual and stuck as diploids, but can also lead to the formation of new species. Here, we report the genome sequences of 27 isolates of the pathogenic yeast Candida orthopsilosis. We find that most isolates are diploid hybrids, products of mating between two unknown parental species (A and B) that are 5% divergent in sequence. Isolates vary greatly in the extent of homogenization between A and B, making their genomes a mosaic of highly heterozygous regions interspersed with homozygous regions. Separate phylogenetic analyses of SNPs in the A- and B-derived portions of the genome produces almost identical trees of the isolates with four major clades. However, the presence of two mutually exclusive genotype combinations at the mating type locus, and recombinant mitochondrial genomes diagnostic of inter-clade mating, shows that the species C. orthopsilosis does not have a single evolutionary origin but was created at least four times by separate interspecies hybridizations between parents A and B. Older hybrids have lost more heterozygosity. We also identify two isolates with homozygous genomes derived exclusively from parent A, which are pure non-hybrid strains. The parallel emergence of the same hybrid species from multiple independent hybridization events is common in plant evolution, but is much less documented in pathogenic fungi.
A Mixed-Methods Case Study of Parent Involvement in an Urban High School Serving Minority Students

Parental involvement in education has been associated with a number of positive outcomes for students. Using a mixed-methods approach, the authors examine how role construction and self-efficacy (psychological motivators), invitations (contextual motivators), and life contexts influence a parent’s decision to become involved within the context of an urban high school serving primarily Latino, African American, and immigrant children. Data collection strategies included parent focus groups, teacher interviews, and parent and teacher surveys (N = 73). Findings highlight the importance of school invitations and considering family culture when engaging parents. The authors also compare involvement strategies and barriers as identified by parents and teachers.
Comparison of the Changes in Thickness of the Abdominal Wall Muscles of Stroke Patients According to the Duration of Their Illness as Observed Using Ultrasonographic Images

[Purpose] This study was conducted in order to investigate the importance of trunk muscle strength in stroke patients. By comparing the thicknesses of the abdominal wall muscles through ultrasonography, relative to the duration of illness, the results of the objective data were applied. [Methods] Thirty stroke patients were divided into three groups including an acute phase group participating in the study within 1 month after the onset of a stroke (n=10), a subacute phase group participating less than 6 months (n=10) after a stroke, and a chronic phase group participating more than 6 months (n=10) after suffering a stroke. The thicknesses of the transversus abdominis muscles (TrA), internal oblique muscle (IO), and the external oblique muscle (EO) were measured at rest and during abdominal draw-in maneuver (ADIM) in a supine hook-lying position, and their differences were compared. [Results] The results showed that, in comparison of the thicknesses of the paretic and nonparetic sides, the TrA of the subacute phase and chronic phase groups showed significant differences. In addition, the IO of the subacute phase group and the EO of the chronic phase groups also showed significant differences. [Conclusion] According to the duration of illness in stroke patients, the abdominal wall muscles become noticeably infirm and asymmetric. By improving their symmetry, the functions of the trunk muscles can be recovered.
Using adaptive sensor ranking to reduce the overhead of the coverage configuration protocol

Several application scenarios of wireless sensor networks require coverage of a given region of interest to be guaranteed. In order to establish a coverage preserving configuration, sensor nodes must coordinate and thus invest precious energy resources for both computation and communication. Reducing this overhead is particularly important in applications requiring frequent recomputations of the coverage configuration. In this paper, we focus on these applications and on a particularly efficient coverage configuration protocol, known as CCP. By introducing a novel adaptive sensor ranking technique, we enable CCP to perform a timely selection of the nodes whose activation guarantees for the fulfillment of the coverage requirement. Simulation results show that our approach achieves a 10% reduction of the communication overhead of CCP.
Race for Your Life: An Analysis of the Role of Race in Erroneous Capital Convictions

Prior research on the role of race in wrongful capital convictions has focused primarily on the race of the defendant. In contrast, this article begins with two case studies that illustrate the impact of the race of the defendant and also the race of the victim in contributing to erroneous convictions. The second section of this article identifies the race of the defendant and the victim in 82 cases where prisoners were released from death row because of doubts about their guilt and in a matched group of inmates who were executed. Through the use of three logistic regression models, the combination of the race of the defendant and the race of the victim is identified as a significant predictor of case outcome (exoneration vs. execution). The results also indicate that an indirect relationship may exist between the combination of the race of the defendant and the victim, the strength of the evidence, and case outcome.
The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways

ABSTRACT The “Spanish influenza” of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection model to define the global host transcriptional response to the eight-gene 1918 virus. To better understand the role of the 1918 virus NS1 gene, we also evaluated the host response to a reassortant 1918 virus containing the NS1 gene from A/Texas/36/91 (a seasonal isolate of human influenza virus), as well as the host response to a reassortant of A/Texas/36/91 containing the 1918 NS1 gene. Genomic analyses revealed that the 1918 virus blocked the transcription of multiple interferon-stimulated genes and also downregulated a network of genes associated with lipid metabolism. In contrast, the expression of genes encoding chemokines and cytokines, which serve to attract infiltrating immune cells, was upregulated. Viruses containing the NS1 gene from A/Texas/36/91 induced a significant increase in type I interferon signaling but did not repress lipid metabolism. The 1918 NS1 gene may therefore have contributed to the virulence of the 1918 pandemic virus by disrupting the innate immune response, inducing hypercytokinemia, and by blocking the transcription of certain lipid-based proinflammatory mediators that function as part of the host antiviral response.
Refining prognostic stratification of human papillomavirus-related oropharyngeal squamous cell carcinoma: different prognosis between T1 and T2

Purpose To validate the 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and investigate whether a modified classification better reflects the prognosis. Materials and Methods Medical records of patients diagnosed with non-metastatic HPV-related OPSCC between 2010 and 2016 at a single institution were retrospectively reviewed. HPV status was determined by immunohistochemical analysis of p16 and/or HPV DNA polymerase chain reaction (PCR). We reclassified TNM stage T0-1 and N0-1 as group A, T2-3 or N2 as B, and T4 or N3 as C. Survival analysis according to 8th AJCC/UICC TNM staging and the modified classification was performed. Results Of 383 OPSCC patients, 211 were positive for HPV DNA PCR or p16. After exclusion, 184 patients were included in this analysis. Median age was 56 years (range, 31 to 81 years). Most primary tumors were in the palatine tonsil (148 tumors, 80%). The eighth AJCC/UICC TNM classification could not differentiate between stage I and II (p = 0.470) or II and III (p = 0.209). Applying modified grouping, the 3-year overall survival rate of group A was significantly higher than that of group B and C (98% vs. 91%, p = 0.039 and 98% vs. 78%, p < 0.001, respectively). Differentiation between group B and C was marginally significant (p = 0.053). Conclusion The 8th AJCC/UICC TNM staging system did not clearly distinguish the prognosis of stage II from that of other stages. Including the T2N0-1 group in stage II may improve prognostic stratification.
Power relations and the production of new knowledge within a Queensland Music Festival community cultural development project

Abstract Conflict during the creative development process of community cultural development projects is inevitable (Adam and Goldbard 2001), yet through the productive use of power (Foucault 1977, 1980, 1982) new knowledge can be created for the festival organization, the community, and individual participants. In this article I identify power/knowledge relations within the Queensland Music Festival community cultural development project Behind the Cane, a three-year project with the South Sea Islander community in Bowen, Queensland, Australia, through a narrative analysis of different stories that my participants told about the project. These stories emphasize strategic and disciplinary power during the creative development process of Behind the Cane, as well as the power of the story and the performance itself and what it meant to the local community and the festival organization. From these stories I explain how new knowledge was created within the community as well as the festival organization.
The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice

Many transporters such as the solute carriers belonging to the Major facilitator superfamily Pfam clan are orphans in that their tissue and cellular localization as well as substrate profile and function are still unknown. Here we have characterized the putative solute carrier UNC93A. We aimed to investigate the expression profile on both protein and mRNA level of UNC93A in mouse since it has not been clarified. UNC93A staining was found in cortex, hippocampus and cerebellum. It was found to be expressed in many neurons, but not all, with staining located in close proximity to the plasma membrane. Furthermore, we aimed to extend the starvation data available for Unc93a in hypothalamic cell cultures from mouse. We investigated the Unc93a alterations with focus on amino acid deprivation in embryonic cortex cells from mice as well as 24 h starvation in adult male mice and compared it to recently studied putative and known solute carriers. Unc93a expression was found both in the brain and peripheral organs, in low to moderate levels in the adult mice and was affected by amino acid deprivation in embryonic cortex cultures and starvation in in vivo samples. In conclusion, the membrane-bound UNC93A is expressed in both the brain and peripheral tissues and responds to nutrient availability in mice.
Growing Up in the Inner City

Children growing up in the inner city are at risk for a range of negative developmental outcomes. Do barren, inner-city neighborhood spaces compromise the everyday activities and experiences necessary for healthy development? Sixty-four urban public housing outdoor spaces (27 low vegetation, 37 high vegetation) were observed on four separate occasions. Overall, inner-city children's everyday activities and access to adults appeared remarkably healthy; of the 262 children observed, most (73%) were involved in some type of play, and most groups of children (87%) were supervised to some degree. In relatively barren spaces, however, the picture was considerably less optimistic: Levels of play and access to adults were approximately half as much as those found in spaces with more trees and grass, and the incidence of creative play was significantly lower in barren spaces than in relatively green spaces.
Forty years of eating disorder-focused family therapy – the legacy of ‘psychosomatic families’

ABSTRACT Minuchin, Rosman and Baker published Psychosomatic families. Anorexia nervosa in context in 1978, which is the culmination of their work in developing a conceptual model of anorexia nervosa (and diabetes and asthma) that would inform a model of family intervention. The psychosomatic family model itself has been challenged empirically, through the development of family therapy for adolescent anorexia nervosa and last, but not least, through the increased understanding of the complex aetiology of anorexia nervosa. The positive outcomes of Minuchin and colleagues series and the description of their interventions came to form the basis for research and treatment that has influenced the field in reaching a position where we see families as a solution rather than a problem, the best resource to aid their child's recovery.
A Theory of Electronic Propinquity

This paper proposes a theoretical approach to mediated communication in organizations. It is argued that the man-machine interface in mediated human communication is better dealt with when a comprehensive theoretical approach is used, than when separate communication devices are tested as they appear in the market, such as video-teleconferencing. Propinquity is considered to be the system's trait which is essential for the continuation of the human communication system in organizations. In a structural-functional analysis, six propositions, 15 derived corollaries, and two-limits propositions are presented. The variables included in the propositions are: (a) perceived propinquity; (b) perceived bandwidth; (c) perceived complexity of the information; (d) perceived degree of mutual directionality of the channel; (e) communication skills; (f) perceived communication rules; (g) perceived number of choices among channels; (h) perceived conflict; and (i) perceived turbulence in the environment. Evidence from past research is used to support the perspective presented.
The length and variability of the human menstrual cycle.

The Center for Population Research collected 30,655 recorded menstrual cycles from 2,316 women. Ninety-five percent of all cycles were between 15 and 45 days long. The mean and standard deviations for the total number of cycles were 29.1 and 7.46, respectively. Cycle lengths between 15 and 45 days averaged 28.1 days with a standard deviation of 3.95 days. Variability of menstrual-cycle lengths is highest for women under 25 years of age and declines steadily to reach a minimum for ages 35 to 39. It is then followed by a slight increase for women aged 40 to 44. The pattern of variability by age is demonstrated equally well by the percent of cycles between 25 and 31 days in length as by the standard deviation.