Miracle-dz/UniFAR-FTUs huggingface dataset:
Developing a (Bad) Habit: Antecedents and Adverse Consequences of Social Networking Website Use Habit

IS habit has emerged as an important determinant of continued use. In this study, we advance our understanding of this concept by shifting attention from desired IS use outcomes, which have been the focus of past IS continuance and habit research, to potential adverse outcomes of IS habit, namely technology addiction and high engagement. We argue that “bad” IS habits can also develop, and explore their nomological net. We do so with SEM techniques applied to data collected from 197 social networking website users.
Active Learning for Multi-Objective Optimization

In many fields one encounters the challenge of identifying, out of a pool of possible designs, those that simultaneously optimize multiple objectives. This means that usually there is not one optimal design but an entire set of Pareto-optimal ones with optimal tradeoffs in the objectives. In many applications, evaluating one design is expensive; thus, an exhaustive search for the Pareto-optimal set is unfeasible. To address this challenge, we propose the Pareto Active Learning (PAL) algorithm which intelligently samples the design space to predict the Pareto-optimal set. Key features of PAL include (1) modeling the objectives as samples from a Gaussian process distribution to capture structure and accomodate noisy evaluation; (2) a method to carefully choose the next design to evaluate to maximize progress; and (3) the ability to control prediction accuracy and sampling cost. We provide theoretical bounds on PAL's sampling cost required to achieve a desired accuracy. Further, we show an experimental evaluation on three real-world data sets. The results show PAL's effectiveness; in particular it improves significantly over a state-of-the-art multi-objective optimization method, saving in many cases about 33% evaluations to achieve the same accuracy.
Theory Solving Made Easy with Clingo 5

Answer Set Programming (ASP) is a model, ground, and solve paradigm. The integration of application- or theory-specific reasoning into ASP systems thus impacts on many if not all elements of its workflow, viz. input language, grounding, intermediate language, solving, and output format. We address this challenge with the fifth generation of the ASP system clingo and its grounding and solving components by equipping them with well-defined generic interfaces facilitating the manifold integration efforts. On the grounder's side, we introduce a generic way of specifying language extensions and propose an intermediate format accommodating their ground representation. At the solver end, this is accompanied by high-level interfaces easing the integration of theory propagators dealing with these extensions.
Parsing Word Clusters

We present and discuss experiments in statistical parsing of French, where terminal forms used during training and parsing are replaced by more general symbols, particularly clusters of words obtained through un-supervised linear clustering. We build on the work of Candito and Crabbe (2009) who proposed to use clusters built over slightly coarsened French inflected forms. We investigate the alternative method of building clusters over lemma/part-of-speech pairs, using a raw corpus automatically tagged and lemmatized. We find that both methods lead to comparable improvement over the baseline (we obtain F1=86.20% and F1=86.21% respectively, compared to a baseline of F1=84.10%). Yet, when we replace gold lemma/POS pairs with their corresponding cluster, we obtain an upper bound (F1=87.80) that suggests room for improvement for this technique, should tag-ging/lemmatisation performance increase for French. We also analyze the improvement in performance for both techniques with respect to word frequency. We find that replacing word forms with clusters improves attachment performance for words that are originally either unknown or low-frequency, since these words are replaced by cluster symbols that tend to have higher frequencies. Furthermore, clustering also helps significantly for medium to high frequency words, suggesting that training on word clusters leads to better probability estimates for these words.
Time-frequency analysis for surface roughness characterization using backscatter ultrasound

The determination of a surface roughness with translation velocity was investigated with an ultrasonic backscattering technique based on the Doppler effect. The difficulty of the Fourier analysis to detect with accuracy the changes of roughness led us to implement a time-frequency analysis. We demonstrate that the spectrum of the demodulated signal is related to the spatial spectrum of the surface roughness, and the velocity of the surface. An accurate detection of roughness can be performed thanks to the spectrogram representation.
Accounting for Dynamic Fluctuations across Time when Examining fMRI Test-Retest Reliability: Analysis of a Reward Paradigm in the EMBARC Study

Longitudinal investigation of the neural correlates of reward processing in depression may represent an important step in defining effective biomarkers for antidepressant treatment outcome prediction, but the reliability of reward-related activation is not well understood. Thirty-seven healthy control participants were scanned using fMRI while performing a reward-related guessing task on two occasions, approximately one week apart. Two main contrasts were examined: right ventral striatum (VS) activation fMRI BOLD signal related to signed prediction errors (PE) and reward expectancy (RE). We also examined bilateral visual cortex activation coupled to outcome anticipation. Significant VS PE-related activity was observed at the first testing session, but at the second testing session, VS PE-related activation was significantly reduced. Conversely, significant VS RE-related activity was observed at time 2 but not time 1. Increases in VS RE-related activity from time 1 to time 2 were significantly associated with decreases in VS PE-related activity from time 1 to time 2 across participants. Intraclass correlations (ICCs) in VS were very low. By contrast, visual cortex activation had much larger ICCs, particularly in individuals with high quality data. Dynamic changes in brain activation are widely predicted, and failure to account for these changes could lead to inaccurate evaluations of the reliability of functional MRI signals. Conventional measures of reliability cannot distinguish between changes specified by algorithmic models of neural function and noisy signal. Here, we provide evidence for the former possibility: reward-related VS activations follow the pattern predicted by temporal difference models of reward learning but have low ICCs.
Sieve Element Ca2+ Channels as Relay Stations between Remote Stimuli and Sieve Tube Occlusion in Vicia faba[W]

Damage induces remote occlusion of sieve tubes in Vicia faba by forisome dispersion, triggered during the passage of an electropotential wave (EPW). This study addresses the role of Ca2+ channels and cytosolic Ca2+ elevation as a link between EPWs and forisome dispersion. Ca2+ channel antagonists affect the initial phase of the EPW as well as the prolonged plateau phase. Resting levels of sieve tube Ca2+ of ∼50 nM were independently estimated using Ca2+-selective electrodes and a Ca2+-sensitive dye. Transient changes in cytosolic Ca2+ were observed in phloem tissue in response to remote stimuli and showed profiles similar to those of EPWs. The measured elevation of Ca2+ in sieve tubes was below the threshold necessary for forisome dispersion. Therefore, forisomes need to be associated with Ca2+ release sites. We found an association between forisomes and endoplasmic reticulum (ER) at sieve plates and pore-plasmodesma units where high-affinity binding of a fluorescent Ca2+ channel blocker mapped an increased density of Ca2+ channels. In conclusion, propagation of EPWs in response to remote stimuli is linked to forisome dispersion through transiently high levels of parietal Ca2+, release of which depends on both plasma membrane and ER Ca2+ channels.
Residual Stresses, Surface Roughness, and Tool Wear in Hard Turning: A Comprehensive Review

Hard turning is used in the manufacturing industry as an economic alternative to grinding, but the reliability of hard turning processes is often unpredictable. The main factors affecting the reliability of hard turning are surface integrity and tool wear. In the present study, an attempt has been made to investigate the effect of cutting parameters on surface roughness, tool wear, and residual stress distribution in hard turning. This article brings out the comprehensive analysis of the effects of cutting parameters on surface roughness, residual stress, and tool wear.
Physician perspectives on a tailored multifaceted primary care practice facilitation intervention for improvement of cardiovascular care.

BACKGROUND Practice facilitation is an effective way to help physicians implement change in their clinics, but little is known about physicians' perspectives on this service. OBJECTIVES To examine physicians' responses to a practice facilitation program, focussing on their overall satisfaction, perceived most significant clinical changes, and interactions with the facilitator. METHODS The Improved Delivery of Cardiovascular Care program investigated the impact of practice facilitation on improving the quality of cardiovascular primary care in Eastern Ontario, Canada, from 2007 to 2011. We conducted a qualitative content analysis of post-intervention surveys completed by participating physicians, using a constant comparison approach framed around the Chronic Care Model. RESULTS Ninety-five physicians completed the survey. Physicians overwhelmingly viewed the program positively, though descriptions of its benefits and impact varied widely. Facilitators filled three key roles for physicians, acting as a resource centre, motivator and outside perspective. Physicians adopted a number of changes in their practices. These changes include adoption of clinical information systems (diabetes registries), decision support tools (chart audits, guideline documents, flow sheets) and delivery system design (community resources). CONCLUSIONS Most physicians appreciated having access to a practice facilitator and viewed the intervention positively. Insight into physicians' perspectives on practice facilitation provides a valuable counterpoint to outcomes-based evaluations of such services. Further research should investigate potential obstacles in the group of physicians who make fewer practice changes, as well as the sustainability of this type of facilitation intervention.
Immunoadsorption therapy in dilated cardiomyopathy

Dilated cardiomyopathy is a common myocardial disease characterized by ventricular chamber enlargement and systolic dysfunction that result in heart failure. In addition to genetic predisposition, viral infection and myocardial inflammation play a causal role in the disease process of dilated cardiomyopathy. Experimental and clinical studies suggest that activation of the humoral immune system, with production of circulating cardiac autoantibodies, plays an important functional role in the development and progression of cardiac dysfunction in patients with dilated cardiomyopathy. Small open-controlled studies showed that removal of circulating antibodies by immunoadsorption results in improvement of cardiac function and decrease in myocardial inflammation. At present, immunoadsorption is an experimental treatment option for improvement of cardiac function – therapy that calls for confirmation by a placebo-controlled multicenter study.
Morphological decomposition involving non-productive morphemes: ERP evidence

It is generally believed that readers decompose a complex word into its constituent morphemes only when those morphemes participate productively in word formation. Here we recorded event-related potentials (ERPs) to words (e.g. muffler, receive), non-words containing no morphemes (e.g. flermuf), and non-words containing a prefix and a non-productive bound stem (e.g. in-ceive). Prior work has shown that pronounceable non-words elicit larger-amplitude N400 components than words. If readers treat non-words containing non-productive morphemes as unanalyzed wholes, then these non-words should elicit larger N400 s than matched words. We report here, however, that bound-stem non-words elicit a brain response highly similar to that elicited by real words. This finding suggests that morphological decomposition and representation extend to non-productive morphemes.
Epilepsy, Antiseizure Therapy, and Sleep Cycle Parameters

A reciprocal relationship exists between sleep and epilepsy. The quality of sleep is affected by the presence and frequency of seizures, type of antiepileptic therapy utilized, and coexisting primary sleep disorders. Daytime somnolence is one of the most common adverse effects of antiepileptic therapy, with specific pharmacologic agents exhibiting a unique influence on components of sleep architecture. The newer generation of antiseizure drugs demonstrates improved sleep efficiency, greater stabilization of sleep architecture, prolongation of REM sleep duration, and increased quality of life measures. The emerging field of chronoepileptology explores the relationship between seizures and circadian rhythms, aiming for targeted use of antiseizure therapies to maximize therapeutic effects and minimize the adverse events experienced by the patients.
Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines

Two receptors, neuropilin 1 (NP1) and neuropilin 2 (NP2), bind class 3 semaphorins, axon guidance molecules including SEMA3F, the gene for which was isolated from a 3p21.3 deletion in lung cancer. In addition, they bind VEGF (vascular endothelial growth factor), enhancing the effects of VEGF binding to KDR/Flk‐1. Elevated VEGF levels are associated with the loss and cytoplasmic delocalization of SEMA3F in lung cancer, suggesting competition for their NP1 and NP2 receptors. To determine the timing of these events, we compared by immunohistochemistry VEGF, SEMA3F, NP1 and NP2 expression in 50 preneoplastic lesions and 112 lung tumours. In preneoplastic lesions, VEGF increased from low‐grade to high‐grade dysplasia (p = 0.001) whereas SEMA3F levels remained low. NP1 and NP2 levels increased from dysplasia to microinvasive carcinoma (p = 0.0001) and correlated with VEGF expression (p = 0.04 and 0.0002, respectively). Non‐small cell lung carcinoma overexpressed VEGF and NP1 and NP2 significantly more often than neuroendocrine tumours including small cell lung carcinoma. SEMA3F loss or delocalization correlated with advanced tumour stage. Migrating cells overexpressed VEGF, SEMA3F, NP1 and NP2 with cytoplasmic delocalization of NP1 as demonstrated in an in vitro wound assay. These results demonstrate early alteration of the VEGF/SEMA3F/NP pathway in lung cancer progression. Copyright © 2003 John Wiley & Sons, Ltd.
An expression quantitative trait loci-guided co-expression analysis for constructing regulatory network using a rice recombinant inbred line population

The ability to reveal the regulatory architecture of genes at the whole-genome level by constructing a regulatory network is critical for understanding the biological processes and developmental programmes of organisms. Here, we conducted an eQTL-guided function-related co-expression analysis to identify the putative regulators and construct gene regulatory network. We performed an eQTL analysis of 210 recombinant inbred lines (RILs) derived from a cross between two indica rice lines, Zhenshan 97 and Minghui 63, the parents of an elite hybrid, using data obtained by hybridizing RNA samples of flag leaves at the heading stage with Affymetrix whole-genome arrays. Making use of an ultrahigh-density single-nucleotide polymorphism bin map constructed by population sequencing, 13 647 eQTLs for 10 725 e-traits were detected, comprising 5079 cis-eQTLs (37.2%) and 8568 trans-eQTLs (62.8%). The analysis revealed 138 trans-eQTLs hotspots, each of which apparently regulates the expression variations of many genes. Co-expression analysis of functionally related genes within the framework of regulator–target relationships outlined by the eQTLs led to the identification of putative regulators in the system. The usefulness of the strategy was demonstrated with the genes known to be involved in flowering. We also applied this strategy to the analysis of QTLs for yield traits, which also suggested likely candidate genes. eQTL-guided co-expression analysis may provide a promising solution for outlining a framework for the complex regulatory network of an organism.
Mirror Neurons and the Evolution of Embodied Language

Mirror neurons are a class of neurons first discovered in the monkey premotor cortex that activate both when the monkey executes an action and when it observes the same action made by another individual. These neurons enable individuals to understand actions performed by others. Two subcategories of mirror neurons in monkeys activate when they listen to action sounds and when they observe communicative gestures made by others, respectively. The properties of mirror neurons could constitute a substrate from which more sophisticated forms of communication evolved; this would make sense, given the anatomical and functional homology between part of the monkey premotor cortex and Broca's area (the “speech” area of the brain) in humans. We hypothesize that several components of human language, including some aspects of phonology and syntax, could be embedded in the organizational properties of the motor system and that a deeper knowledge of this system could shed light on how language evolved.
Environmental concentrations and bioaccumulations of cadmium and zinc in coastal watersheds along the Chinese Northern Bohai and Yellow Seas

Cadmium (Cd) and zinc (Zn) in surface water, sediment, carp, and crab samples collected from upstream and downstream regions of coastal watersheds along the Chinese Northern Bohai and Yellow Seas were analyzed to provide a comprehensive understanding and assessment of their environmental concentrations and bioaccumulations. The results showed that downstream waters contaminated with Zn would have adverse effects on aquatic organisms. Although nearly all sediments were contaminated with Cd due to human activities, little potential existed for Cd toxicity in sediment‐dwelling fauna. Concentrations of Cd and Zn in most water, sediment, carp, and crab were less than published values. The downstream carp and crabs had higher mean bioaccumulation factors and biota‐sediment accumulation factors for Cd but lower mean biota‐sediment accumulation factors for Zn than the upstream carp and crabs. Based on the relationships among Cd and Zn concentrations in water, sediment, and biota, the authors conclude that Cd and Zn in crabs primarily derived from sediment exposure. Although Cd and Zn in water and sediment originated from some of the same sources, the sources of Cd or Zn in water were likely different from those in sediment. Environ. Toxicol. Chem. 2013;32:831–840. © 2013 SETAC
Clinicopathological assessment of the nephron number

Recent studies have demonstrated much larger variability in the total number of nephrons in normal populations than previously suspected. In addition, it has been suggested that individuals with a low nephron number may have an increased lifetime risk of hypertension or renal insufficiency, emphasizing the importance of evaluating the nephron number in each individual. In view of the fact that all previous reports of the nephron number were based on analyses of autopsy kidneys, the identification of surrogate markers detectable in living subjects is needed in order to enhance understanding of the clinical significance of this parameter. In this review, we summarize the clinicopathological factors and findings indicating a reduction in the nephron number, focusing particularly on those found at the time of a preserved renal function.
Round and Extracted$rm Nb_3rm Sn$Strand Tests for LARP Magnet R&amp;D

The first step in the magnet R&D of the U.S. LHC Accelerator Research Program (LARP) is fabrication of technology quadrupoles TQS01 and TQC01. These are two-layer magnets which use cables of same geometry made of 0.7 mm MJR Nb3Sn. Through strand billet qualification and tests of strands extracted from the cables, predictions of magnet performance are made. Measurements included the critical current, Ic, using the voltage-current (VI) method at constant field, the stability current, IS, as the minimal quench current obtained with the voltage-field (VH) method at constant current in the sample, and RRR. Magnetization was measured at low and high fields to determine the effective filament size and to detect flux jumps. Effects of heat treatment duration and temperature on Ic and IS were also studied. The Nb3Sn strand and cable samples, the equipment, measurement procedures, and results are described. Based on these results, strand specifications were formulated for next LARP quadrupole models
Activity‐dependent redistribution of Kv2.1 ion channels on rat spinal motoneurons

Homeostatic plasticity occurs through diverse cellular and synaptic mechanisms, and extensive investigations over the preceding decade have established Kv2.1 ion channels as key homeostatic regulatory elements in several central neuronal systems. As in these cellular systems, Kv2.1 channels in spinal motoneurons (MNs) localize within large somatic membrane clusters. However, their role in regulating motoneuron activity is not fully established in vivo. We have previously demonstrated marked Kv2.1 channel redistribution in MNs following in vitro glutamate application and in vivo peripheral nerve injury (Romer et al., 2014, Brain Research, 1547:1–15). Here, we extend these findings through the novel use of a fully intact, in vivo rat preparation to show that Kv2.1 ion channels in lumbar MNs rapidly and reversibly redistribute throughout the somatic membrane following 10 min of electrophysiological sensory and/or motor nerve stimulation. These data establish that Kv2.1 channels are remarkably responsive in vivo to electrically evoked and synaptically driven action potentials in MNs, and strongly implicate motoneuron Kv2.1 channels in the rapid homeostatic response to altered neuronal activity.