Miracle-dz/UniFAR-FTUs huggingface dataset:
Continuous-wave optical modulation at the frequency of molecular motion

The novel scheme for lightwave modulation based on ultrafast modulation of polarizability induced by a coherently excited molecular motion has attracted attention as an alternative to a widely-used optical modulator based on an electro-optic effect to extend it to much higher frequency. A pulsed laser was first used to demonstrate the feasibility of this approach, and recently a cavity enhanced continuous-wave (cw) laser was successfully applied to the optical modulation based on the coherent molecular rotations. The efficiency of the sideband generation, however, was considerably low (~10-6) for the cw laser modulation. In the report, the intensity of the cw-based sideband was dramatically improved, approaching 50% for an anti-Stokes sideband, by the fulfillment of a phase-matching condition of the sideband generation. A high-finesse optical cavity (HFC) consisting of a pair of broadband (750-930 nm) high reflective (R: ~99.98%) mirrors having a negative dispersion (~ -7 fs2) to enhance the intensity of a pump (ω1: 847.9 nm) and a probe (ωprobe: 855.8 nm) beam was used in this study.
Circulating donor-specific anti-human leukocyte antigen antibodies and complement C4d deposition are associated with the development of cardiac allograft vasculopathy.

BACKGROUND Cardiac allograft vasculopathy (CAV) continues to be a limiting factor in long-term survival of heart transplant recipients (HTRs). Pathophysiologic and immunologic factors affecting CAV are complex, and criteria for early diagnosis remain elusive. METHODS We performed a retrospective analysis of the relationship between donor-specific antibody (DSA), C4d immunofluorescence, and the development of CAV. RESULTS We evaluated 330 endomyocardial biopsy (EMB) specimens from 112 cardiac grafts. Twenty-four (21%) of 112 grafts developed CAV, and 18 (75%) of 24 were positive for C4d. Patients with DSA (n = 51) against human leukocyte antigen class I (n = 5), II (n = 26), or both (n = 20) developed CAV at a rate of 40%, 38%, and 20% and a mean time to CAV of 89, 47, and 25 months, respectively. Of 61 grafts without DSA, only 13% developed CAV, with a mean time to CAV of 116 months. CONCLUSIONS Compared with the general HTR population, patients with graft dysfunction and DSA or positive C4d on EMB show a statistically significant increased incidence of CAV and allograft failure, suggesting an antibody-mediated injury. The presence of pre- and posttransplant DSA, even in the absence of positive C4d immunofluorescence, may identify a group of HTRs at increased risk of developing CAV.
Why MMORPG players do what they do: relating motivations to action categories

This paper presents an analysis of relations between player motivation and behaviour in a Massively Multiplayer Online Role-Playing Game (MMORPG). Player motivation is measured in terms of percentile ranks of motivational components for MMORPG players defined by Nick Yee. Player behaviour is described through previously defined action categories for MMORPGs (Trading, Questing, Dungeons, Raiding, Player versus Player Combat, and Communication). We conduct a player survey and perform measurements on the client side for a group of 104 players of World of Warcraft. Additionally we examine the importance of both voice and textual communication in MMORPGs.
An Assessment of Performance Evaluation Feedback in Governmental Secondary School, Jos North L.G.A Plateau State

The aim of this study is to assess the level of Performance evaluation feedback in governmental secondary schools in Jos North Local Government Area. However, both primary and secondary sources of data collection were employed. The primary sources of data were obtained through administering 210 structured questionnaires to teachers in all 21 governmental secondary schools in Jos North Local Government Area (Nigeria). While the secondary sources of data were obtained from text books, journals and internet sources. The three hypotheses study were tested using Chi-square at 0.5% significance level. On the whole, alternative hypotheses of the study were upheld which states that teachers in governmental secondary schools in Jos North Local Government Area are satisfied with the performance evaluation feedback they got. Secondly, that teachers in governmental secondary schools in Jos North Local Government Area get feedback from performance evaluation and that there are diverse opinions on when performance evaluation should be conducted among teachers in governmental secondary schools in Jos North Local Government Area.
Perspective Perspective: Promoting Healthy Aging through Nutrition: A Research Centers Collaborative Network Workshop Report ☆

and other social determinants of health need to be considered. The Research Centers Collaborative Network sponsored a 1.5-d multidisciplinary workshop that included sessions on dietary patterns in health and disease, timing and targeting interventions, and health disparities and the social context of diet and food choice. The agenda and presentations can be found at https://www.rccn-aging.org/nutrition-2023-rccn-workshop. Here we summarize the workshop ’ s themes and discussions and highlight research gaps that if ﬁ lled will considerably advance our understanding of the role of nutrition in healthy aging.
'Hard' is 'soft': exploring the dangers of the 'hard'/'soft' distinction

This paper argues that the hard/soft distinction used in relation to new management interventions is potentially dangerous because it serves to reproduce the status quo by reinforcing taken-for-granted assumptions about the world. Thus considering innovations to be 'hard' can result in a failure to think through the social implications of one's actions. It is suggested that our understanding of organisations can be enhanced through reflecting on the dichotomy and its underlying assumptions. It is thought that through such reflection, the number of innovations that are instigated with little thought for employees and their Quality of Working Life can be reduced, even though asymmetrical power relations are likely to remain. These issues are explored by drawing on some qualitative research from a company that introduced Statistical Process Control (SPC), which has been described as a 'hard' intervention, in conjunction with Total Quality Management (TQM).
Development and Validation of a Machine Learning Prognostic Model of m5C Related immune Genes in Lung Adenocarcinoma

Background The aim of this retrospective research was to develop an immune-related genes significantly associated with m5C methylation methylation (m5C-IRGs)-related signature associated with lung adenocarainoma (LUAD). Methods We introduced transcriptome data to screen out m5C-IRGs in The Cancer Genome Atlas (TCGA)-LUAD dataset. Subsequently, the m5C-IRGs associated with survival were certificated by Kaplan Meier (K-M) analysis. The univariate Cox, least absolute shrinkage and selection operator (LASSO) regression, and xgboost.surv tool were adopted to build a LUAD prognostic signature. We further conducted gene functional enrichment, immune microenvironment and immunotherapy analysis between 2 risk subgroups. Finally, we verified m5C-IRGs-related prognostic gene expression in transcription level. Results A total of 76 m5C-IRGs were identified in TCGA-LUAD dataset. Furthermore, 27 m5C-IRGs associated with survival were retained. Then, a m5C-IRGs prognostic signature was build based on the 3 prognostic genes (HLA-DMB, PPIA, and GPI). Independent prognostic analysis suggested that stage and RiskScore could be used as independent prognostic factors. We found that 4104 differentially expressed genes (DEGs) between the 2 risk subgroups were mainly concerned in immune receptor pathways. We found certain distinction in LUAD immune microenvironment between the 2 risk subgroups. Then, immunotherapy analysis and chemotherapeutic drug sensitivity results indicated that the m5C-IRGs-related gene signature might be applied as a therapy predictor. Finally, we found significant higher expression of PPIA and GPI in LUAD group compared to the normal group. Conclusions The prognostic signature comprised of HLA-DMB, PPIA, and GPI based on m5C-IRGs was established, which might provide theoretical basis and reference value for the research of LUAD. Public Datasets Analyzed in the Study TCGA-LUAD dataset was collected from the TCGA (https://portal.gdc.cancer.gov/) database, GSE31210 (validation set) was retrieved from GEO (https://www.ncbi.nlm.nih.gov/geo/) database.
Can CT Screening Give Rise to a Beneficial Stage Shift in Lung Cancer Patients? Systematic Review and Meta-Analysis

Objectives To portray the stage characteristics of lung cancers detected in CT screenings, and explore whether there’s universal stage superiority over other methods for various pathological types using available data worldwide in a meta-analysis approach. Materials and Methods EMBASE and MEDLINE were searched for studies on lung cancer CT screening in natural populations through July 2015 without language or other filters. Twenty-four studies (8 trials and 16 cohorts) involving 1875 CT-detected lung cancer patients were enrolled and assessed by QUADAS-2. Pathology-confirmed stage information was carefully extracted by two reviewers. Stage I or limited stage proportions were pooled by random effect model with Freeman-Tukey double arcsine transformation. Results Pooled stage I cancer proportion in CT screenings was 73.2% (95% confidence interval: 68.6%, 77.5%), with a significant rising trend (Ptrend<0.05) from baseline (64.7%) to ≥5 repeat rounds (87.1%). Relative to chest radiograph and usual care, the increased stage I proportions in CT were 12.2% (P>0.05), and 46.5% (P<0.05), respectively. Pathology-specifically, adenocarcinomas (66%) and squamous cell lung cancers (17%) composed the majority of CT-detected lung cancers, and had significantly higher stage I proportions relative to chest radiograph (bronchioloalveolar adenocarcinomas, 80.9% vs 51.4%; other adenocarcinomas, 58.8% vs 38.3%; squamous cell lung cancers, 52.3% vs 38.3%; all P<0.05). However, the percentage of small cell lung cancer was lower using CT than other detection routes, and no significant difference in limited stage proportion was observed (6.8% vs 10.8%, P>0.05). Conclusion CT screening can detect more early stage non-small cell lung cancers, but not all of them could be beneficial as there are a considerable number of indolent ones such as bronchioloalveolar adenocarcinomas. Still, current evidence is lacking regarding small cell lung cancers.
Phylogenomics and the Dynamic Genome Evolution of the Genus Streptococcus

The genus Streptococcus comprises important pathogens that have a severe impact on human health and are responsible for substantial economic losses to agriculture. Here, we utilize 46 Streptococcus genome sequences (44 species), including eight species sequenced here, to provide the first genomic level insight into the evolutionary history and genetic basis underlying the functional diversity of all major groups of this genus. Gene gain/loss analysis revealed a dynamic pattern of genome evolution characterized by an initial period of gene gain followed by a period of loss, as the major groups within the genus diversified. This was followed by a period of genome expansion associated with the origins of the present extant species. The pattern is concordant with an emerging view that genomes evolve through a dynamic process of expansion and streamlining. A large proportion of the pan-genome has experienced lateral gene transfer (LGT) with causative factors, such as relatedness and shared environment, operating over different evolutionary scales. Multiple gene ontology terms were significantly enriched for each group, and mapping terms onto the phylogeny showed that those corresponding to genes born on branches leading to the major groups represented approximately one-fifth of those enriched. Furthermore, despite the extensive LGT, several biochemical characteristics have been retained since group formation, suggesting genomic cohesiveness through time, and that these characteristics may be fundamental to each group. For example, proteolysis: mitis group; urea metabolism: salivarius group; carbohydrate metabolism: pyogenic group; and transcription regulation: bovis group.
Severe hemorrhagic complications during remission induction therapy for acute promyelocytic leukemia: incidence, risk factors, and influence on outcome

Background: Even after the introduction of all‐trans retinoic acid (ATRA), early hemorrhagic death remains a major cause of remission induction failure for acute promyelocytic leukemia (APL). Methods: To investigate severe hemorrhagic complications during remission induction therapy with respect to incidence, risk factors, and influence on outcome. Results were analyzed for 279 patients enrolled in the APL97 study conducted by the Japan Adult Leukemia Study Group (JALSG). Results: Severe hemorrhage occurred in 18 patients (6.5%). Although most of them were receiving frequent transfusions, the targeted levels of platelet counts (30 × 109/L) and plasma fibrinogen (1.5 g/L) for this study were reached at the day of bleeding in only 71% and 40%, respectively. Nine of them succumbed to an early death, while the remaining nine patients eventually achieved complete remission (CR). The 5‐yr event‐free survival rate was 68.1% for those who did not suffer severe hemorrhage, and 31.1% for those who did (P < 0.0001). For patients who achieved CR, on the other hand, there was no difference in disease‐free survival between patients with and without severe hemorrhage (P = 0.6043). Risk factor analysis identified three pretreatment variables associated with severe hemorrhage: initial fibrinogen level, white blood cell count, and performance status. Additionally, patients with severe hemorrhage were more easily prone to develop retinoic acid syndrome or pneumonia than patients without hemorrhage. Conclusions: These results indicate that fatal hemorrhage represents a major obstacle in curing APL, and that patients with such high‐risk features may benefit from more aggressive supportive care.
Mississippi River : Natchez to Baton Rouge Hydraulic and Sediment Transport Model

This report documents the development, calibration, and validation of a hydraulic and sediment transport model of the Mississippi River between Natchez, MS, and Baton Rouge, LA, conducted for the U.S. Army Corps of Engineers, Mississippi Valley Division, Vicksburg, MS, using the Coastal and Hydraulics Laboratory-developed Adaptive Hydraulics numerical code. The numerical model adequately replicates the water levels observed in the field including a wide range of conditions from an extreme flood (Flood of 2011) to an extreme drought (2012). With the inclusion of the Old River Control Complex and Morganza Control Structure, this model is available to evaluate alternative operational procedures and associated relative water level impacts between these two structures for both normal and extreme flow conditions. This study further advanced the goal of the Mississippi River and Tributaries program in terms of developing numerical models to analyze the Lower Mississippi River in terms of shortand long-term impacts to the system. DISCLAIMER: The contents of this report are not to be used for advertising, publication, or promotional purposes. Citation of trade names does not constitute an official endorsement or approval of the use of such commercial products. All product names and trademarks cited are the property of their respective owners. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. DESTROY THIS REPORT WHEN NO LONGER NEEDED. DO NOT RETURN IT TO THE ORIGINATOR. MRG&P Report No. 19 iii
[Are mood stabilizers beneficial in the treatment of schizophrenia?].

BACKGROUND Antipsychotic agents are the drugs of choice in the treatment of schizophrenia. However, some patients profit only modestly from such therapy and thus represent a clinical challenge. MATERIAL AND METHODS This article is based upon a review of relevant literature on treatment with the mood stabilizers lithium, carbamazepine, valproate and lamotrigine in patients with schizophrenia. RESULTS Few well-designed studies exist on the use of mood stabilizers in schizophrenia. In monotherapy, these drugs have no documented beneficial effect, but when used as adjunct therapies to antipsychotics, some positive effects are described. Best evidence for an anti-aggressive effect exists for lithium, but it is described also for carbamazepine. Lithium also has some effects on affective symptoms. Valproate has not shown a consistently positive effect. Lamotrigine has demonstrated a beneficial effect in a placebo-controlled study, but this finding should be verified by others before its place in the treatment of schizophrenia can be established. INTERPRETATION Mood stabilizers are not the drugs of choice in the treatment of schizophrenia but could be considered as potential adjuncts to antipsychotics in patients with treatment-resistant schizophrenia, although the documentation is sparse.
Design of Microstrip Patch Antennas Using Neural Network

This paper presents the general design of microstrip antennas using artificial neural networks for rectangular patch geometry. The design consists of synthesis in the forward side and then analyzed as the reverse side of the problem. In this work, the neural network is employed as a tool in design of microstrip antennas. The Neural network Training algorithms are used in simulation of results for training the samples to minimize the error and to obtain the geometric dimensions with high accuracy for selective band of frequencies.
Utilization of Services Provided by Village-Based Ethnic Minority Midwives in Vietnam: Lessons From Implementation Research

Background: Global progress in reducing maternal mortality requires improving access to maternal and child health services for the most vulnerable groups. This article reports results of implementation research that aimed to increase the acceptability of village-based ethnic minority midwives (EMMs) by local communities in Vietnam through implementing an integrated interventions package. Methods: The study was carried out in 2 provinces in Vietnam, Dien Bien and Kon Tum. A quasi-experimental survey with pretest/posttest design was adopted, which included 6 months of intervention implementation. The interventions package included introductory “launch” meetings, monthly review meetings at community health centers, and 5-day refresher training for EMMs. A mixed-methods approach was used involving both quantitative and qualitative data. A structured questionnaire was used in the pre- and posttest surveys, complemented by in-depth interviews and focus group discussions with EMMs, relatives of pregnant women, community representatives, and health managers. Results: Introductions of EMMs to their local communities by local authorities and supervision of performance of EMMs contributed to significant increases in utilization of services provided by EMMs, from 58.6% to 87.7%. Key facilitators included information on how to contact EMMs, awareness of services provided by EMMs, and trust in services provided by EMMs. The main barriers to utilization of EMM services, which may affect sustainability of the EMM scheme, were low self-esteem of EMMs and small allowances to EMMs, which also affected the recognition of EMMs in the community. Conclusions: Providing continuous support and integration of EMMs within frontline service provision and ensuring adequate local budget for monthly allowances are the key factors that should allow sustainability of the EMM scheme and continued improvement of access to maternal and child health care among poor ethnic minority people living in mountainous areas in Vietnam.
Quantification and assessment of effective of global warming on the occurrence of heat and cold waves in some selected stations in Iran

One of the atmospheric hazards that seriously affect human life and health is the occurrence of thermal tensions and stress in the form of heat and cold waves. Iran is one of the areas of the planet that has climate variability due to its geographical characteristics; therefore, consequently, its different regions are not immune to heat and cold waves. On the other hand, Iran's climate variability is the factor causing the difference between thresholds of heat and cold wave occurrence for its different regions. Therefore, in this study, based on three different thresholds, spatial analysis of the frequency of occurrence of heat and cold waves has been done. Thus in this work, using average daily data from 1960 to 2014, PET (Physiological Equivalent Temperature) was used to monitor heat and cold waves of four stations in Iran. Results of this study showed that in the context of global warming, although significant differences in the frequency of cold waves cannot be seen, these changes are significant and increasing for the frequency of occurrence of heat waves of selected station.
The Destruction of Cosmological Minihalos by Primordial Supernovae

We present numerical simulations of primordial supernovae in cosmological minihalos at z ∼ 20. We consider Type II supernovae, hypernovae, and pair instability supernovae (PISN) in halos from 6.9 × 105 to 1.2 × 107 M☉, those in which Population III stars are expected to form via H2 cooling. Our simulations are the first to follow the evolution of the blast from a free expansion on spatial scales of 10−4 pc until its approach to pressure equilibrium in the relic H II region of the progenitor, ~1000 pc. Supernovae in H II regions first expand adiabatically and then radiate strongly upon collision with baryons ejected from the halo during its photoevaporation by the progenitor. In contrast to previous findings, supernovae in neutral halos promptly emit most of their kinetic energy as X-rays, but retain enough momentum to seriously disrupt the halo. Explosions in H II regions escape into the IGM, but neutral halos confine the blast and its metals. In H II regions, a prompt second generation of stars may form in the remnant at radii of 100-200 pc. Explosions confined by massive halos instead recollapse, with infall rates in excess of 10−2 M☉ yr−1 that heavily contaminate their interior. This fallback may either fuel massive black hole growth at very high redshifts or create the first globular clusters with radii of 10-20 pc at the center of the halo. Our findings suggest that the first primitive galaxies may therefore have formed sooner, with greater numbers of stars and distinct chemical signatures, than in current models.