Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of dispersal in the recruitment limitation of neotropical pioneer species

1 We examined the importance of seed dispersal in predicting the pioneer seedling composition in recent gaps in a forest plot on Barro Colorado Island (BCI), Panama. We characterize seed dispersal for 13 taxa from seed rain data collected over 13 years in 200 mesh traps, and for an additional species from germination from soil samples collected in one year. We describe seedling distribution patterns from a complete census of all seedlings of these 14 taxa present in 36 treefall gaps. 2 A maximum likelihood model, incorporating both distance to adult trees and tree size, fitted observed seed rain to traps quite well for all taxa. 3 The ability to predict seedling recruit number per gap varied greatly among taxa. For 8 of 14 taxa, regression models incorporating predicted seed rain were significantly better predictors of seedling recruitment than models in which recruitment probability was assumed constant in all sites. 4 To see if variation in local dispersal patterns determined the community composition of gaps, we examined the relative abundances of these 14 pioneer taxa in the 36 gaps. We found that taxon abundances were significantly positively correlated with abundances predicted from seed dispersal models and seed–seedling regressions for 27 out of 36 gaps. 5 Overall, we find evidence that limited seed dispersal is an important factor contributing, together with factors affecting post‐dispersal recruitment success, to seedling distribution patterns in gaps.
Optic disc drusen: understanding an old problem from a new perspective

Optic disc drusen (ODD) are acellular deposits located in the optic nerve head of up to 2.4% of the population. They may develop as by‐products of impaired axonal metabolism in genetically predisposed individuals, in whom a narrow scleral canal is hypothesized to play a role. Although ODD are often considered as benign innocent bystanders, recognized as part of a routine ophthalmological examination, the vast majority of patients with ODD have visual field defects. Optic disc drusen (ODD)‐associated complications with severe visual loss, most often due to anterior ischaemic optic neuropathy, are also known to occur. There are no treatments available to prevent or ameliorate the vision loss caused by ODD. In children, the ODD are usually uncalcified and buried within the optic nerve head tissue. In these cases, the condition can be difficult to diagnose, as it often resembles a papilloedema with optic nerve head swelling caused by raised intracranial pressure. During the teenage years, the ODD progressively become more calcified and probably also larger, which allow them to be visible on ophthalmoscopy. With the advent and proper utilization of high‐resolution modalities of optical coherence tomography (OCT), it has now become possible to detect even the smallest and most deeply located ODD. This allows for ODD detection at a much earlier developmental stage than has previously been possible and enhances the possibilities of research in underlying mechanisms. A review of the literature on ODD was conducted using the PUBMED database. The review focuses on the current knowledge regarding pathogenesis, diagnostics, clinical disease‐tracking methodologies, structure–function relationships and treatment strategies of ODD.
Salt Intake and Knowledge of Salt Intake in a Chinese Population: A Crosssectional Study

Consuming too much salt greatly increases the risk of heart disease and stroke, and limited studies focused on knowledge of salt intake in relation to salt consumption. Our study aimed to investigate salt intake and knowledge of salt intake in a Chinese population. Altogether 42114 adults aged 18 years and above were selected by multi-stage cluster sampling method. Salt consumption and knowledge of salt intake were assessed by self-reported questionnaire. The average salt intake was 15.5 ± 11.9 g/d, and 85.2% of subjects with excessive salt intake. Almost 80% of dietary salt came from salt, followed by salty vegetable (13.5%) and soy sauce (3.3%). There were 28.3% participants knowing the National recommended salt intake, and 29.7% with knowledge of excess salt intake resulting in hypertension. Overall 57.6% participants had ever been received health education on low-salt diet. After adjustment of confounders, subjects without knowledge of salt intake had a higher risk of excessive salt intake. Salt intake is high in the Chinese population. Awareness of salt intake is low, and it is inappropriate with current health education.
Occupational Hazards among Dentists: A Descriptive Study

Background: This study was conducted to assess occupational hazards among the dental surgeons of Bellary city. Methods: Descriptive cross sectional survey was conducted using a self-administrated questionnaire. Results: Study showed 92.4% (n=61) dentists faced with physical hazards, 13.6% (n=9) chemical hazards, 63.6% (n=42) Biological, 78.7% (n=52) psychological hazards. None of the dentists faced any litigation problems. Dentists with clinical experience less than 5 years had greater prevalence of physical hazard (93.3%, n=14/15). Conclusion: The physical activities and body positions that predispose dentists to backaches. Continuing education programmes have to be conducted to overcome these hazards.
Characterization of preclinical in vitro and in vivo pharmacokinetics properties for KBP-7018, a new tyrosine kinase inhibitor candidate for treatment of idiopathic pulmonary fibrosis

KBP-7018 is a novel selective tyrosine kinase inhibitor with potential for the treatment of idiopathic pulmonary fibrosis. The objective of this study was to characterize the preclinical pharmacokinetics of KBP-7018 in vitro and in vivo, and then to assess the likelihood of developing KBP-7018 as a clinical candidate. The systemic clearance (CL) of KBP-7018 was relatively low in rodents and monkeys with a value of less than 30% of hepatic blood flow, while it was high in dogs. The steady-state volume of distribution (Vss) ranged from 1.51 L/kg to 4.65 L/kg across the species tested. The maximum concentration (Cmax) of KBP-7018 occurred at 0.25–6 hours after oral dosing, and the bioavailability was moderate (21%–68%). The human CL (~20% of hepatic blood flow) and Vss (1.6–5.3 L/kg) were predicted by allometric scaling method and together with the other modeling methods indicated low metabolism and acceptable half-time (4.8–19.3 hours) in vivo. Overall, the preclinical data make it amenable to further oral solid dosage from design for the upcoming Phase I trials in human.
Noninvasive Vascular Displacement Estimation for Relative Elastic Modulus Reconstruction in Transversal Imaging Planes

Atherosclerotic plaque rupture can initiate stroke or myocardial infarction. Lipid-rich plaques with thin fibrous caps have a higher risk to rupture than fibrotic plaques. Elastic moduli differ for lipid-rich and fibrous tissue and can be reconstructed using tissue displacements estimated from intravascular ultrasound radiofrequency (RF) data acquisitions. This study investigated if modulus reconstruction is possible for noninvasive RF acquisitions of vessels in transverse imaging planes using an iterative 2D cross-correlation based displacement estimation algorithm. Furthermore, since it is known that displacements can be improved by compounding of displacements estimated at various beam steering angles, we compared the performance of the modulus reconstruction with and without compounding. For the comparison, simulated and experimental RF data were generated of various vessel-mimicking phantoms. Reconstruction errors were less than 10%, which seems adequate for distinguishing lipid-rich from fibrous tissue. Compounding outperformed single-angle reconstruction: the interquartile range of the reconstructed moduli for the various homogeneous phantom layers was approximately two times smaller. Additionally, the estimated lateral displacements were a factor of 2–3 better matched to the displacements corresponding to the reconstructed modulus distribution. Thus, noninvasive elastic modulus reconstruction is possible for transverse vessel cross sections using this cross-correlation method and is more accurate with compounding.
IRscope: an online program to visualize the junction sites of chloroplast genomes

Motivation Genome plotting is performed using a wide range of visualizations tools each with emphasis on a different informative dimension of the genome. These tools can provide a deeper insight into the genomic structure of the organism. Results Here, we announce a new visualization tool that is specifically designed for chloroplast genomes. It allows the users to depict the genetic architecture of up to ten chloroplast genomes in the vicinity of the sites connecting the inverted repeats to the short and long single copy regions. The software and its dependent libraries are fully coded in R and the reflected plot is scaled up to realistic size of nucleotide base pairs in the vicinity of the junction sites. We introduce a website for easier use of the program and R source code of the software to be used in case of preferences to be changed and integrated into personal pipelines. The input of the program is an annotation GenBank (.gb) file, the accession or GI number of the sequence or a DOGMA output file. The software was tested using over a 100 embryophyte chloroplast genomes and in all cases a reliable output was obtained. Availability and implementation Source codes and the online suit available at https://irscope.shinyapps. io/irapp/ or https://github.com/Limpfrog/irscope.
F11R Expression upon Hypoxia Is Regulated by RNA Editing

F11R is a cell adhesion molecule found on the surface of human platelets. It plays a role in platelet aggregation, cell migration and cell proliferation. F11R is subjected to RNA editing, a post-transcriptional modification which affects RNA structure, stability, localization, translation and splicing. RNA editing in the 3'UTR of F11R and RNA levels are increased upon hypoxia. We therefore set to examine if RNA editing plays a role in the increase of F11R RNA seen upon hypoxic conditions. We show that ADAR1, but not ADAR2, takes part in the editing of F11R however editing alone is not sufficient for obtaining an elevation in RNA levels. In addition we show that hyper-edited mature mRNAs are retained in the nucleus and are associated with p54nrb. We therefore conclude that hypoxia-induced edited RNAs of F11R are preferentially stabilized and accumulate in the nucleus preventing their export to the cytoplasm for translation. This mechanism may be used by additional proteins in the cell as part of the cell's effort to reduce metabolism upon hypoxic stress.
Strong coupling superconductivity in a quasiperiodic host-guest structure

The quasiperiodic structure of high-pressure bismuth gives rise to unusually strong electron-phonon coupling. We examine the low-temperature states supported by the quasiperiodic host-guest structure of elemental bismuth at high pressure, Bi-III. Our electronic transport and magnetization experiments establish Bi-III as a rare example of type II superconductivity in an element, with a record upper critical field of ~ 2.5 T, unusually strong electron-phonon coupling, and an anomalously large, linear temperature dependence of the electrical resistivity in the normal state. These properties may be attributed to the peculiar phonon spectrum of incommensurate host-guest structures, which exhibit additional quasi-acoustic sliding modes, suggesting a pathway toward strong coupling superconductivity with the potential for enhanced transition temperatures and high critical fields.
Evaluating Effects of an Oral Green Tea Extract, Polyphenon E, on Tissue Biomarkers, Using Reverse Phase Protein Array in Women with Operable Breast Cancer

Breast cancer chemoprevention with anti-estrogens has been shown to reduce the incidence of estrogen receptor (ER)-positive tumors [1, 2], however, we have yet to identify effective chemopreventive agents for ER-negative tumors. A growing body of evidence suggests a potential chemopreventive effect of green tea in breast cancer. A recent meta-analysis, encompassing 5,617 breast cancer cases, reported an inverse association between green tea consumption and breast cancer incidence and risk of recurrence [3]. Experimental data have demonstrated the anti-cancer effects of the main component of green tea, epigallocatechin3-gallate (EGCG) [4]. In preclinical studies, the anti-tumor effects of EGCG on breast cancer cells were independent of ER status [5]. Proposed mechanisms of action of EGCG include downregulation of key cell signaling pathways in breast carcinogenesis, such as the PI3K/AKT pathway [6, 7]. However, there is limited data on the target tissue effects of tea polyphenols in breast cancer from human intervention trials.
SMA Human iPSC-Derived Motor Neurons Show Perturbed Differentiation and Reduced miR-335-5p Expression

Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by mutations in the Survival Motor Neuron 1 gene, resulting in very low levels of functional Survival of Motor Neuron (SMN) protein. SMA human induced Pluripotent Stem Cells (hiPSCs) represent a useful and valid model for the study of the disorder, as they provide in vitro the target cells. MicroRNAs (miRNAs) are often reported as playing a key role in regulating neuronal differentiation and fate specification. In this study SMA hiPSCs have been differentiated towards early motor neurons and their molecular and immunocytochemical profile were compared to those of wild type cells. Cell cycle proliferation was also evaluated by fluorescence-activated cell sorting (FACS). SMA hiPSCs showed an increased proliferation rate and also higher levels of stem cell markers. Moreover; when differentiated towards early motor neurons they expressed lower levels of NCAM and MN specific markers. The expression of miR-335-5p; already identified to control self-renewal or differentiation of mouse embryonic stem cells (mESCs); resulted to be reduced during the early steps of differentiation of SMA hiPSCs compared to wild type cells. These results suggest that we should speculate a role of this miRNA both in stemness characteristic and in differentiation efficiency of these cells.
Neural Mechanisms of Qigong Sensory Training Massage for Children With Autism Spectrum Disorder: A Feasibility Study

Objectives Despite the enormous prevalence of autism spectrum disorder (ASD), its global impact has yet to be realized. Millions of families worldwide need effective treatments to help them get through everyday challenges like eating, sleeping, digestion, and social interaction. Qigong Sensory Training (QST) is a nonverbal, parent-delivered intervention recently shown to be effective at reducing these everyday challenges in children with ASD. This study tested the feasibility of a protocol for investigating QST’s neural mechanism. Methods During a single visit, 20 children, 4- to 7-year-old, with ASD viewed images of emotional faces before and after receiving QST or watching a video (controls). Heart rate variability was recorded throughout the visit, and power in the high frequency band (0.15–0.4 Hz) was calculated to estimate parasympathetic tone in 5-s nonoverlapping windows. Cerebral oximetry of prefrontal cortex was recorded during rest and while viewing emotional faces. Results 95% completion rate and 7.6% missing data met a priori standards confirming protocol feasibility for future studies. Preliminary data suggest: (1) during the intervention, parasympathetic tone increased more in children receiving massage (M = 2.9, SD = 0.3) versus controls (M = 2.5, SD = 0.5); (2) while viewing emotional faces post-intervention, parasympathetic tone was more affected (reduced) in the massage group (p = 0.036); and (3) prefrontal cortex response to emotional faces was greater after massage compared to controls. These results did not reach statistical significance in this small study powered to test feasibility. Discussion/Conclusion This study demonstrates solid protocol feasibility. If replicated in a larger sample, these findings would provide important clues to the neural mechanism of action underlying QST’s efficacy for improving sensory, social, and communication difficulties in children with autism.
Coexistence of systemic lupus erythematosus and multiple sclerosis. A case report and literature review

Multiple sclerosis (MS) and systemic lupus erythematous (SLE) are autoimmune diseases, the coexistence of which is uncommon in patients. Owing to the rarity of this condition, the distinction between MS and SLE is a diagnostic challenge for neurologists. We present a case report in which MS and SLE were present in the same patient. There are few case reports in the world on the association between MS and SLE. The following case report is the first of its kind in which both MS and SLE are present in a patient from a country with low prevalence of MS such as Ecuador.
Anatomical aspects of angiosperm root evolution.

BACKGROUND AND AIMS Anatomy had been one of the foundations in our understanding of plant evolutionary trends and, although recent evo-devo concepts are mostly based on molecular genetics, classical structural information remains useful as ever. Of the various plant organs, the roots have been the least studied, primarily because of the difficulty in obtaining materials, particularly from large woody species. Therefore, this review aims to provide an overview of the information that has accumulated on the anatomy of angiosperm roots and to present possible evolutionary trends between representatives of the major angiosperm clades. SCOPE This review covers an overview of the various aspects of the evolutionary origin of the root. The results and discussion focus on angiosperm root anatomy and evolution covering representatives from basal angiosperms, magnoliids, monocots and eudicots. We use information from the literature as well as new data from our own research. KEY FINDINGS The organization of the root apical meristem (RAM) of Nymphaeales allows for the ground meristem and protoderm to be derived from the same group of initials, similar to those of the monocots, whereas in Amborellales, magnoliids and eudicots, it is their protoderm and lateral rootcap which are derived from the same group of initials. Most members of Nymphaeales are similar to monocots in having ephemeral primary roots and so adventitious roots predominate, whereas Amborellales, Austrobaileyales, magnoliids and eudicots are generally characterized by having primary roots that give rise to a taproot system. Nymphaeales and monocots often have polyarch (heptarch or more) steles, whereas the rest of the basal angiosperms, magnoliids and eudicots usually have diarch to hexarch steles. CONCLUSIONS Angiosperms exhibit highly varied structural patterns in RAM organization; cortex, epidermis and rootcap origins; and stele patterns. Generally, however, Amborellales, magnoliids and, possibly, Austrobaileyales are more similar to eudicots, and the Nymphaeales are strongly structurally associated with the monocots, especially the Acorales.
Seed dispersal by ants in the semi-arid Caatinga of North-East Brazil.

BACKGROUND AND AIMS Myrmecochory is a conspicuous feature of several sclerophyll ecosystems around the world but it has received little attention in the semi-arid areas of South America. This study addresses the importance of seed dispersal by ants in a 2500-km(2) area of the Caatinga ecosystem (north-east Brazil) and investigates ant-derived benefits to the plant through myrmecochory. METHODS Seed manipulation and dispersal by ants was investigated during a 3-year period in the Xingó region. Both plant and ant assemblages involved in seed dispersal were described and ant behaviour was characterized. True myrmecochorous seeds of seven Euphorbiaceae species (i.e. elaiosome-bearing seeds) were used in experiments designed to: (1) quantify the rates of seed cleaning/removal and the influence of both seed size and elaiosome presence on seed removal; (2) identify the fate of seeds dispersed by ants; and (3) document the benefits of seed dispersal by ants in terms of seed germination and seedling growth. KEY RESULTS Seed dispersal by ants involved one-quarter of the woody flora inhabiting the Xingó region, but true myrmecochory was restricted to 12.8 % of the woody plant species. Myrmecochorous seeds manipulated by ants faced high levels of seed removal (38-84 %) and 83 % of removed seeds were discarded on ant nests. Moreover, seed removal positively correlated with the presence of elaiosome, and elaiosome removal increased germination success by at least 30 %. Finally, some Euphorbiaceae species presented both increased germination and seedling growth on ant-nest soils. CONCLUSIONS Myrmecochory is a relevant seed dispersal mode in the Caatinga ecosystem, and is particularly frequent among Euphorbiaceae trees and shrubs. The fact that seeds reach micro-sites suitable for establishment (ant nests) supports the directed dispersal hypothesis as a possible force favouring myrmecochory in this ecosystem. Ecosystems with a high frequency of myrmecochorous plants appear not to be restricted to regions of nutrient-impoverished soil or to fire-prone regions.
Using Deep Data Augmentation Training to Address Software and Hardware Heterogeneities in Wearable and Smartphone Sensing Devices

A small variation in mobile hardware and software can potentially cause a significant heterogeneity or variation in the sensor data each device collects. For example, the microphone and accelerometer sensors on different devices can respond very differently to the same audio or motion phenomena. Other factors, like the instantaneous computational load on a smartphone, can cause key behavior like sensor sampling rates to fluctuate, further polluting the data. When sensing devices are deployed in unconstrained and real-world conditions, examples of sharply lower classification accuracy are observed due to what is collectively known as the sensing system heterogeneity. In this work, we take an unconventional approach and argue against solving individual forms of heterogeneity, e.g., improving OS behavior, or the quality/uniformity of components. Instead, we propose and build classifiers that themselves are more tolerant of these variations by leveraging deep learning and a data-augmented training process. Neither augmentation nor deep learning has previously been attempted to cope with sensor heterogeneity. We systematically investigate how these two machine learning methodologies can be adapted to solve such problems, and identify when and where they are able to be successful. We find that our proposed approach is able to reduce classifier errors on an average by 9% and 17% for a range of inertial-and audio-based mobile classification tasks.