Miracle-dz/UniFAR-FTUs huggingface dataset:
KDM5B overexpression predicts a poor prognosis in patients with squamous cell carcinoma of the head and neck

Purpose: Lysine demethylase (KDM) 5B, as a member of the histone lysine demethylase family, is overexpressed and functions abnormally in various human cancers. However, its expression in the squamous cell carcinoma of the head and neck (SCCHN) remains unclear. Methods: KDM5B expression was analyzed by immunohistochemistry and correlated with clinicopathological parameters in 103 archival SCCHN tissue samples and 24 adjacent noncancerous epithelial tissues. Results: We found that KDM5B expression was higher in SCCHN than that in adjacent noncancerous tissues. This was closely associated with lymph node metastasis and tumor recurrence. In addition, Kaplan-Meier analysis revealed that patients with high KDM5B expression had shorter disease-free and overall survival times than those with low KDM5B expression. Importantly, both univariate and multivariate analysis demonstrated that KDM5B level was an independent prognostic factor in SCCHN patients. Conclusions: These results indicate that KDM5B is a valuable biomarker that can be used to predict SCCHN patient outcome.
Origin Single-stranded DNA Releases Sld3 Protein from the Mcm2–7 Complex, Allowing the GINS Tetramer to Bind the Mcm2–7 Complex*

The replication fork helicase in eukaryotic cells is comprised of Cdc45, Mcm2–7, and GINS (CMG complex). In budding yeast, Sld3, Sld2, and Dpb11 are required for the initiation of DNA replication, but Sld3 and Dpb11 do not travel with the replication fork. Sld3 and Cdc45 bind to early replication origins during the G1 phase of the cell cycle, whereas Sld2, GINS, polymerase ϵ, and Dpb11 form a transient preloading complex that associates with origins during S phase. We show here that Sld3 binds tightly to origin single-stranded DNA (ssDNA). CDK-phosphorylated Sld3 binds to origin ssDNA with similar high affinity. Origin ssDNA does not disrupt the interaction between Sld3 and Dpb11, and origin ssDNA does not disrupt the interaction between Sld3 and Cdc45. However, origin ssDNA substantially disrupts the interaction between Sld3 and Mcm2–7. GINS and Sld3 compete with one another for binding to Mcm2–7. However, in a mixture of Sld3, GINS, and Mcm2–7, origin ssDNA inhibits the interaction between Sld3 and Mcm2–7, whereas origin ssDNA promotes the association between GINS and Mcm2–7. We also show that origin single-stranded DNA promotes the formation of the CMG complex. We conclude that origin single-stranded DNA releases Sld3 from Mcm2–7, allowing GINS to bind Mcm2–7.
On the complexity and approximation of syntenic distance

Abstract The paper studies the computational complexity and approximation algorithms for a new evolutionary distance between multi-chromosomal genomes introduced recently by Ferretti, Nadeau and Sankoff. Here, a chromosome is represented as a set of genes and a genome is a collections of chromosomes. The syntenic distance between two genomes is defined as the minimum number of translocations, fusions and fissions required to transform one genome into the other. We prove that computing the syntenic distance is NP-hard and give a simple approximation algorithm with performance ratio 2. For the case when an upper bound d on the syntenic distance is known, we show that an optimal syntenic sequence can be found in O(nk + 2o(d2)) time, where n and k are the number of chromosomes in the two given genomes. Next, we show that if the set of operations for transforming a genome is significantly restricted, we can nevertheless find a solution that performs at most O(log d) additional moves, where d is the number of moves performed by the unrestricted optimum. This result should help in the design of approximation algorithms. Finally, we investigate the median problem: Given three genomes, construct a genome minimizing the total syntenic distance to the three given genomes and compute the corresponding median distance. The problem has application in the inference of phytogenies based on the syntenic distance. We prove that the problem is NP-hard and design a polynomial time approximation algorithm with a performance ratio of 4+e for any constant e > 0.
Tracer arrival timing‐insensitive technique for estimating flow in MR perfusion‐weighted imaging using singular value decomposition with a block‐circulant deconvolution matrix

Relative cerebral blood flow (CBF) and tissue mean transit time (MTT) estimates from bolus‐tracking MR perfusion‐weighted imaging (PWI) have been shown to be sensitive to delay and dispersion when using singular value decomposition (SVD) with a single measured arterial input function. This study proposes a technique that is made time‐shift insensitive by the use of a block‐circulant matrix for deconvolution with (oSVD) and without (cSVD) minimization of oscillation of the derived residue function. The performances of these methods are compared with standard SVD (sSVD) in both numerical simulations and in clinically acquired data. An additional index of disturbed hemodynamics (oDelay) is proposed that represents the tracer arrival time difference between the AIF and tissue signal. Results show that PWI estimates from sSVD are weighted by tracer arrival time differences, while those from oSVD and cSVD are not. oSVD also provides estimates that are less sensitive to blood volume compared to cSVD. Using PWI data that can be routinely collected clinically, oSVD shows promise in providing tracer arrival timing‐insensitive flow estimates and hence a more specific indicator of ischemic injury. Shift maps can continue to provide a sensitive reflection of disturbed hemodynamics. Magn Reson Med 50:164–174, 2003. © 2003 Wiley‐Liss, Inc.
Career and College Advice to the Forgotten Half: What Do Counselors and Vocational Teachers Advise?.

Projections from the U.S. Chamber of Commerce and the Bureau of Labor Statistics suggest that many of the fastest-growing jobs in the U.S. will require some form of postsecondary education — be it technical certification, an associate’s degree, a bachelor’s degree or beyond. And although the vast majority of students (and their parents) express the belief that they will go to college, research indicates that the actual number of young people — particularly low-income and minority youth — entering postsecondary education falls far below these stated expectations.
A Reliability Study of Shostrom's Personal Orientation Inventory

THERE can be little doubt that the focus of activity and interest in the mental health field is presently undergoing a significant change. The emphasis, in terms of legislation, education, training, research, and professional activities, is clearly moving away from an orientation of pathology and deficit to one of prevention and psychological health (Bennett, 1966; Bellak, 1964; Caplan, 1964). Several fruitful, though by no means adequately developed, formulations of healthy personalities and growth-oriented theories have been forwarded by Maslow (1954, 1962, 1964, 1965), Rogers (1951, 1961), and Allport (1955), among others. One of the outgrowths of the changing emphasis has been the emergence of assessment techniques which concern themselves with psychological health (Jourard, 1964; Maslow, 1964, 1965). One of the most promising of these appears to be Shostrom's Personal Orientation Inventory (1964, 1966). This is a 150-item, two-choice questionnaire, which has 12 sub-scales and requires about 30 minutes to administer. All the items are scored twice; first for two basic ratio scales of personal orientation -inner-directed support (127 items) and time competence (23 items). The second scoring is for 10 subscales consisting of from 9-32 items. Each scale measures a conceptually-relevant aspect of self-actualization. The scales, as described by Shostrom (1966), are briefly as follows:
Meeting the Mixed Methods Challenge of Integration in a Sociological Study of Structure and Agency

Substantial integration of quantitative and qualitative data and findings in mixed methods studies is seldom seen, although maximizing the potential of the approach depends on this. An absence of exemplars has been identified as among a number of factors that currently impede integration in studies carried out by researchers using the approach. This article offers an example of how maximum integration of data sets can be achieved. The sociological study discussed used a combination of methods—questionnaire survey, group interviews, and individual interviews—to obtain a fuller view of young people's perspectives on their lives. Aspects of the project's research design and analyses that were instrumental to achieving a genuinely integrated mixed methods approach are identified.
Cosmos Caudatus as a Potential Source of Polyphenolic Compounds: Optimisation of Oven Drying Conditions and Characterisation of Its Functional Properties

The aim of the study was to analyze the influence of oven thermal processing of Cosmos caudatus on the total polyphenolic content (TPC) and antioxidant capacity (DPPH) of two different solvent extracts (80% methanol, and 80% ethanol). Sonication was used to extract bioactive compounds from this herb. The results showed that the optimised conditions for the oven drying method for 80% methanol and 80% ethanol were 44.5 °C for 4 h with an IC50 of 0.045 mg/mL and 43.12 °C for 4.05 h with an IC50 of 0.055 mg/mL, respectively. The predicted values for TPC under the optimised conditions for 80% methanol and 80% ethanol were 16.5 and15.8 mg GAE/100 g DW, respectively. The results obtained from this study demonstrate that Cosmos caudatus can be used as a potential source of antioxidants for food and medicinal applications.
"Out" in the field. Reflecting on the dilemmas of insider status on data collection and conducting interviews with gay men

Purpose – The purpose of this paper is to explore using a reflexive approach the impact of author's personal positioning on issues of power balance between the interviewer and the interviewee, dealing with sensitive stories and concerns of difference and sameness between participants and the researcher in both the data collection process and also during the interviews. Design/methodology/approach – Initial data were gathered from 45 semi-structured interviews with self-identified gay men in a wide range of occupations and ages working in the seaside resort of Bournemouth on the south coast of England. Findings – The paper highlights some of the dilemmas of insider status and doing research on gay men. These include: ethical issues of closeness and involvement with participants, dealing with author's own personal frustrations, tackling the power imbalance between the interviewer and the interviewee and the impact of author's personal positioning on the data collection. Originality/value – Little research h.
Dysfunction of liver regeneration in aged liver after partial hepatectomy

A remarkable feature of the liver is its regenerative capacity following partial hepatectomy. However, the regenerative capacity of many organs and tissues loses its natural ability to divide with aging. In this study, we investigated the association of aging with endoplasmic reticulum stress, the cell cycle, autophagy, and apoptosis‐related genes during liver regeneration after hepatectomy.
Self-control strength in prison inmates with antisocial personality disorder

The present study aimed to examine the difference in self-control strength between individuals with and without antisocial personality disorder (ASPD) in a Chinese male prisoner sample. Thirty-seven male inmates who met the criteria for DSM-IV ASPD and 38 who did not were asked to watch a four-minute silent videotape of an interview, and ignore the words displayed on screen during the videotape to deplete their ego strength. A handgrip task was conducted both before and after watching the videotape, with participants’ time squeezing the handgrip being the dependent variable. Result showed a significant interaction between group (ASPD/no-ASPD group) and time (baseline/post-manipulation measure). The post-manipulation result was significantly worse than the baseline result for the ASPD group, but not for the no-ASPD group. These results indicate that tasks that contribute to ego depletion lead to a deficit of self-control strength in prisoners with ASPD.
Towards the Maturation and Characterization of Smooth Muscle Cells Derived from Human Embryonic Stem Cells

In this study we demonstrate that CD34+ cells derived from human embryonic stem cells (hESCs) have higher smooth muscle cell (SMC) potential than CD34− cells. We report that from all inductive signals tested, retinoic acid (RA) and platelet derived growth factor (PDGFBB) are the most effective agents in guiding the differentiation of CD34+ cells into smooth muscle progenitor cells (SMPCs) characterized by the expression of SMC genes and proteins, secretion of SMC-related cytokines, contraction in response to depolarization agents and vasoactive peptides and expression of SMC-related genes in a 3D environment. These cells are also characterized by a low organization of the contractile proteins and the contractility response is mediated by Ca2+, which involves the activation of Rho A/Rho kinase- and Ca2+/calmodulin (CaM)/myosin light chain kinase (MLCK)-dependent pathways. We further show that SMPCs obtained from the differentiation of CD34+ cells with RA, but not with PDGFBB, can be maturated in medium supplemented with endothelin-1 showing at the end individualized contractile filaments. Overall the hESC-derived SMCs presented in this work might be an unlimited source of SMCs for tissue engineering and regenerative medicine.
The Role of Organizational Socialization in Burnout: A Taiwanese Example

Previous research predominantly used the conservation of resources (COR) model (Schaufeli & Enzmann, 1998) and the job demands-resources (JD-R) model (Demerouti, Bakker, Nachreiner, & Schaufeli, 2001) to explain burnout. In this study, organizational socialization was examined as a factor to explain and more completely understand burnout. Results from a sample of 397 employees in people-oriented professions and organizations in Taiwan revealed that organizational socialization was significantly related to all three components of burnout: emotional exhaustion, depersonalization, and reduced personal accomplishment. The strength of the prediction was particularly apparent on the dimension of reduced personal accomplishment. The use of organizational socialization as an effective predictor of burnout is a significant departure from previous research.
Currency Matching and Carry Trade by Non-Financial CorporationsJRC Working Papers in Economics and Finance, 2017/2

The paper investigates firms’ willingness to match the currency composition of their assets and liabilities and their incentives to deviate from perfect matching. Using detailed information at the loan contract level for the Hungarian non-financial corporate sector, results show that the probability of borrowing in foreign currency decreases as soon as the firm’s foreign currency debt reimbursement obligation exceeds its expected export revenues. This provides strong evidence to support the role of natural hedging. Matching motivation is even stronger in the aftermath of the crisis, however, it is still not firms’ primary motivation for choosing foreign currency: it explains only about 10 percent of the overall corporate foreign currency debt during the pre-crisis and 20 percent during the post-crisis periods. Besides hedging, our results suggest that both carry trade and diversification strategies are relevant factors in firms’ currency-ofdenomination decisions.
Leave arrangements and childcare services in Central Europe: Policies and practices before and after the transition

The paper provides a comparative analysis of childcare and leave policies in four Central European countries. The first part considers developments in policy since the 1960s, including the first extended leave scheme introduced in Hungary in 1967 and the changes that have taken place since the end of the communist regimes. Although the transition process during the 1990s had many similarities, the emergence of national, cultural and religious identities contributed to some diversification of policies. After certain divergent trends, the Czech Republic and Hungary converged again towards the end of the 1990s, as both countries returned to a pro-natalist approach. Slovakia has retained a balance between pro-natalist and pro-traditional approaches. Poland had less generous policies before 1989: the subsequent political resurgence of Catholicism has accentuated the specificity of that country's policies. The second part discusses major issues arising in the post-1990 period: population policy and fertility; women's employment and the gap between rights and practices in the division of household work; and the specific situation in the Czech Republic. El articulo aporta un análisis comparativo de las políticas del cuidado infantil y permiso laboral (baja por maternidad/paternidad) en los cuatro países centroeuropeos. La primera parte considera el desarrollo de la política desde los 1960s, incluida la primera esquema de permiso prolongado introducido en Hungría en 1967 y los cambios desde el fin de los gobiernos comunistas. Aunque había muchas semejanzas, la aparición de identidades nacionales, culturales y religiosas contribuyó a una diversificación en la política. Después de ciertas tendencias divergentes, la República Checa y Hungría convergieron hacia el fin de los 90s, como ambos países volvieron al planteamiento pro-natalidad. Eslovaquia ha guardado un equilibrio entre enfoques pro-natalidad y pro-tradicional. Polonia tenía políticas menos generosos antes de 1989: el posterior resurgimiento del catolicismo ha subrayado la especificidad de las políticas del país. La segunda parte discute cuestiones que surgieron después de 1990: la política de población y la fertilidad, el empleo de mujeres y la distancia entre derechos y practicas en la división de tareas domesticas, y la situación especifica en la República Checa.
The Spectra of T Dwarfs. I. Near-Infrared Data and Spectral Classification

We present near-infrared spectra for a sample of T dwarfs, including 11 new discoveries made using the 2 Micron All Sky Survey. These objects are distinguished from warmer (L-type) brown dwarfs by the presence of methane absorption bands in the 1-2.5 μm spectral region. A first attempt at a near-infrared classification scheme for T dwarfs is made, based on the strengths of CH4 and H2O bands and the shapes of the 1.25, 1.6, and 2.1 μm flux peaks. Subtypes T1 V-T8 V are defined, and spectral indices useful for classification are presented. The subclasses appear to follow a decreasing Teff scale, based on the evolution of CH4 and H2O bands and the properties of L and T dwarfs with known distances. However, we speculate that this scale is not linear with spectral type for cool dwarfs, due to the settling of dust layers below the photosphere and subsequent rapid evolution of spectral morphology around Teff ~ 1300-1500 K. Similarities in near-infrared colors and continuity of spectral features suggest that the gap between the latest L dwarfs and earliest T dwarfs has been nearly bridged. This argument is strengthened by the possible role of CH4 as a minor absorber, shaping the K-band spectra of the latest L dwarfs. Finally, we discuss one peculiar T dwarf, 2MASS 0937+2931, which has very blue near-infrared colors (J - Ks = -0.89 ± 0.24) due to suppression of the 2.1 μm peak. The feature is likely caused by enhanced collision-induced H2 absorption in a high-pressure or low-metallicity photosphere.
An experimental study of home gateway characteristics

Many residential and small business users connect to the Internet via home gateways, such as DSL and cable modems. The characteristics of these devices heavily influence the quality and performance of the Internet service that these users receive. Anecdotal evidence suggests that an extremely diverse set of behaviors exists in the deployed base, forcing application developers to design for the lowest common denominator. This paper experimentally analyzes some characteristics of a substantial number of different home gateways: binding timeouts, queuing delays, throughput, protocol support and others.
Evidence-informed Leadership in the Japanese Context: Middle managers at a university self-access center

This study reports on the steering of a self-access learning center in a Japanese university by its “middle management” committee over the first years of its operation. Middle management practice was informed by an ethnographic archive of various facets of center use, particularly concerning language policy and curriculum integration, issues about which the archive reveals considerable shifts in stakeholder views over time. It is argued that this evidence-based middle management style has been an effective, but sometimes limited, means in decision-making as it succeeds in placing research at the center of middle management activity, not at its periphery.
Bigger does not mean better! We prefer specificity

This paper studies the applicability of word2vec to the task of extracting similar words from small, domain-specific data. Results show that, even though the general tendency of the community is to focus on using more and more data, the specificity of the corpus has much more influence on word2vec results than its size. Actually, when the goal is to automatically detect similar words that are domain specific, it is necessary to have a corpus that correctly represents the use of those specific words more than to have huge amounts of data unrelated to the targeted language.
Terminally Haunted: Aviation Ghosts, Hybrid Buddhist Practices, and Disaster Aversion Strategies Amongst Airport Workers in Myanmar and Thailand

Much of what is written about airports is from the perspective of a visionary architect, or from the experience of the cosmopolitan traveller. Airport workers, aside from their intimate knowledge of the airport space, know something about terminals that their designers and itinerant occupants do not: how they are haunted. In Yangon, Myanmar and Bangkok, Thailand, airport workers exchange occupational ghost lore regarding sightings, motives and histories of spirits within aviation. They also make use of hybrid Buddhist practices to ward off danger from airport spaces, and to make their own future travels safe and propitious. In addition to challenging the notion of the airport as the ‘non-place’, this paper demonstrates that ecumenical practices and hauntings crucially frame techno-modernity, uniting local and transregional culture with the global semantic legibility of the logistic superstructure of passenger aviation.
Evaluating differences between bare-handed and tool-based interaction in perceptual space

In this paper, we examine the perceptual difference between bare-handed and tool-based interaction by identifying dissimilarities between two perceptual spaces constructed for the two interaction modes. For each interaction mode, four dimensional perceptual spaces are constructed using cluster sorting-based multidimensional scaling with 31 real textured surfaces. In addition, an adjective rating experiment was conducted to understand the meaning of the difference. Distinctive trends and differences of the perceptual spaces were identified. It was seen that familiarity with textured surfaces seemed to decrease the precision of bare-handed interaction, while at the same time it increased classification speed. Furthermore, likely evidence of pre-judgment in tool-based interaction was seen.