Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiveness of group body psychotherapy for negative symptoms of schizophrenia: multicentre randomised controlled trial†

Background Negative symptoms of schizophrenia have a severe impact on functional outcomes and treatment options are limited. Arts therapies are currently recommended but more evidence is required. Aims To assess body psychotherapy as a treatment for negative symptoms compared with an active control (trial registration: ISRCTN84216587). Method Schizophrenia out-patients were randomised into a 20-session body psychotherapy or Pilates group. The primary outcome was negative symptoms at end of treatment. Secondary outcomes included psychopathology, functional, social and treatment satisfaction outcomes at treatment end and 6-months later. Results In total, 275 participants were randomised. The adjusted difference in negative symptoms was 0.03 (95% CI –1.11 to 1.17), indicating no benefit from body psychotherapy. Small improvements in expressive deficits and movement disorder symptoms were detected in favour of body psychotherapy. No other outcomes were significantly different. Conclusions Body psychotherapy does not have a clinically relevant beneficial effect in the treatment of patients with negative symptoms of schizophrenia.
Urovaginal fistula formation after gynaecological and obstetric surgical procedures: Clinical experiences in a Scandinavian series

Abstract Objective. The aim of this retrospective study was to review what kinds of surgical procedures are most frequently complicated by urovaginal fistulae, to find out how they were diagnosed and managed, and to study the outcome after surgical reconstruction. Material and methods. Nineteen women who underwent fistula repair at Sahlgrenska University Hospital between 2003 and 2009 were retrospectively studied by reviewing the medical records. Results. For 17 of the 19 patients hysterectomy was the causative procedure. Fourteen patients developed vesicovaginal and five developed ureterovaginal fistula. Urethrocystoscopy was sufficient for the diagnosis in nearly 50% of the patients and when combined with methylene blue instillation 90% of all fistulae were found. Several patients sought medical advice due to vaginal leakage following gynaecological surgery without the doctor suspecting a fistula, and for these patients the diagnosis was delayed. Eighteen patients were operated on with an abdominal approach and one with a vaginal approach, in all cases a minimum of 3 months after primary surgery. The reconstruction technique included the interposition of vascularized tissue. None of the patients reported leakage or relapse at follow-up after fistula repair. Conclusions. Hysterectomy was the most common cause behind the formation of urovaginal fistulae. Misinterpretation of symptoms after gynaecological surgery was common even in cases where the symptoms were indicative of a urovaginal fistula. Delayed fistula repair after a minimum of 3 months, via the abdominal route and with the interposition of vascularized tissue, yielded an excellent final outcome.
A new wiretap channel model and its strong secrecy capacity

In this paper, a new wiretap channel (WTC) model with a discrete memoryless (DM) main channel and a wiretapper who noiselessly observes a fixed portion, of her choice, of the transmitted symbols, while observing the remaining transmitted symbols through another DM channel (DMC), is considered. The strong secrecy capacity of the model is identified. The achievability is established using the output statistics of random binning framework which exploits the duality between source and channel coding problems. The converse is derived by upper bounding the secrecy capacity of an equivalent model with the secrecy capacity of a DM-WTC. This result generalizes both the classical DM-WTC and the WTC-II with a DM main channel.
Monitoring and control of industrial sewing machines research on thread tension behavior in lockstitch machines

Processing textile materials is generally very difficult due to the flexible nature of the material. In industries using sewing as assembly process, most processes rely on human labor, being difficult or even impossible to automate. The relations between machine configuration and adjustment, material properties, and the resulting product quality are also complex. This paper describes current work using an instrumented lockstitch sewing machine to study the dynamics and variations of one of the important process parameters during high-speed sewing of shirts: thread tensions. The objective is study the principles that may allow for an automatic setting of the machines, quality control and for real-time process control. It has been found that differences in material properties result in measurable features of the thread tension signals acquired.
A novel movement disorder in related male Labrador Retrievers characterized by extreme generalized muscular stiffness.

OBJECTIVES To describe the clinical phenotype of a new motor disorder in Labrador Retrievers. ANIMALS AND METHODS Case series study. Seven young male Labrador Retrievers presented for evaluation of stiff gait. RESULTS All affected dogs had generalized muscular stiffness, persistent at rest and resulting in restricted joint movements. They showed a forward flexed posture, festinating gait, and bradykinesia. Signs developed between 2 and 16 months of age and tended to stabilize in adulthood. Needle electromyogram in the conscious state showed continuous motor unit activity in resting epaxial and proximal limb muscles. This activity was abolished by general anesthesia. Muscle and nerve histopathology was normal. In 2 dogs necropsied, astrocytosis was evident throughout the spinal cord gray matter, reticular formation and caudate nuclei. Decreased neuronal counts were selectively found in the spinal cord Rexed's lamina VII, but not in VIII and IX. Pedigree analysis showed that the affected dogs were from 5 related litters. CONCLUSIONS AND CLINICAL IMPORTANCE This new hypertonicity syndrome in Labrador Retrievers is unique because of the selective distribution of the histological lesions, the lack of progression in adulthood, and its exclusive occurrence in male dogs. Pedigree analysis suggests an X-linked hereditary disease, although other modes of inheritance cannot be ruled out with certainty. We hypothesize that altered output from basal nuclei and reticular formation together with motor neuron disinhibition caused by a decreased number of spinal cord interneurons leads to the muscular stiffness.
Performance Enhancement of Nanoscale VO2 Modulators Using Hybrid Plasmonics

Vanadium dioxide (VO<sub>2</sub>) is a phase change material (PCM) that exhibits a large change in complex refractive index on the order of unity upon switching from its dielectric to its metallic phase. Although this property is key for the design of ultracompact optical modulators of only a few microns in footprint, the high absorption of VO<sub>2</sub> leads to appreciable insertion loss (IL) that limits the modulator performance. In this paper, through theory and numerical modeling, we report on a new paradigm, which demonstrates how the use of a hybrid plasmonic waveguide to construct a VO<sub>2</sub> based modulator can improve the performance by minimizing its IL while achieving high extinction ratio (ER) in comparison to a purely dielectric waveguide. The hybrid plasmonic waveguide that contains an additional metal layer with even higher loss than VO<sub>2</sub> enables unique approaches to engineer the electric field (<italic>E</italic>-field) intensity distribution within the cross section of the modulator. The resulting figure-of-merit, FoM = ER/IL, is much higher than what is possible by simply incorporating VO<sub>2</sub> into a silicon wire waveguide. A practical modulator design using this new approach, which also includes input and output couplers yields ER = 3.8 dB/μm and IL = 1.4 dB/μm (FoM = 2.7), with a 3-dB optical bandwidth >500 nm, in a device length = 2 μm, and cross-sectional dimensions = 200 nm × 450 nm. To the best of our knowledge, this is one of the smallest modulator designs proposed to date that also exhibits amongst the highest ER, FoM, and optical bandwidth, in comparison to existing designs. In addition to VO<sub>2</sub>, we investigate two other PCMs incorporated within the waveguide structure. The improvements obtained for VO<sub>2</sub> modulators do not extend to other PCMs.
Linguistic Integration and Immigrant Health: The Longitudinal Effects of Interethnic Social Capital

The literature on immigrant health has by and large focused on the relationship between acculturation (often measured by a shift in language use) and health outcomes, paying less attention to network processes and the implications of interethnic integration for long-term health. This study frames English-language use among immigrants in the United States as a reflection of bridging social capital that is indicative of social network diversity. Using longitudinal data on self-rated health and the incidence of chronic conditions from the New Immigrant Survey (2003, 2007), I examine the contemporaneous and longitudinal associations between interethnic social capital and health. The results show evidence for a positive long-term effect of linguistic integration on health status, but no cross-sectional associations were observed. Overall, these results highlight the possible role of network processes in linking English-language use with immigrant health and the time-dependent nature of the relationship between linguistic integration and health status.
Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation

Abstract Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a broadly expressed lncRNA involved in many aspects of cellular processes. To further delineate the underlying molecular mechanism, we employed a high-throughput strategy to characterize the interacting proteins of MALAT1 by combining RNA pull-down, quantitative proteomics, bioinformatics, and experimental validation. Our approach identified 127 potential MALAT1-interacting proteins and established a highly connected MALAT1 interactome network consisting of 788 connections. Gene ontology annotation and network analysis showed that MALAT1 was highly involved in five biological processes: RNA processing; gene transcription; ribosomal proteins; protein degradation; and metabolism regulation. The interaction between MALAT1 and depleted in breast cancer 1 (DBC1) was validated using RNA pull-down and RNA immunoprecipitation. Further mechanistic studies reveal that MALAT1 binding competes with the interaction between sirtuin1 (SIRT1) and DBC1, which then releases SIRT1 and enhances its deacetylation activity. Consequently, the deacetylation of p53 reduces the transcription of a spectrum of its downstream target genes, promotes cell proliferation and inhibits cell apoptosis. Our results uncover a novel mechanism by which MALAT1 regulates the activity of p53 through the lncRNA–protein interaction.
Can clinical tests help monitor human papillomavirus vaccine impact?

As immunization programs for human papillomavirus (HPV) are implemented more widely around the world, interest is increasing in measuring their impact. One early measurable impact of HPV vaccine is on the prevalence of specific HPV types in a population. In low‐resource settings, a potentially attractive strategy would be to monitor HPV prevalence using clinical cervical cancer screening test results to triage specimens for HPV typing. We assessed this approach in a nationally representative population of U.S. females aged 14–59 years. Using self‐collected cervico‐vaginal swab specimens from 4,150 women participating in the National Health and Nutrition Examination Survey during 2003–2006, we evaluated type‐specific HPV prevalence detected by the Roche linear array (LA) research test on all specimens, compared with type‐specific HPV prevalence detected by LA conducted only on specimens positive by the digene hybrid capture 2 (HC‐2) clinical test. We calculated weighted prevalence estimates and their 95% confidence intervals (CIs), and examined relative type‐specific HPV prevalence according to the two testing approaches. The population prevalence of oncogenic HPV vaccine types 16/18 was 6.2% (CI:5.4–7.1) by LA if all specimens were tested, and 2.4% (CI:1.9–3.0) if restricted to positive HC‐2. Relative prevalence of individual HPV types was similar for both approaches. Compared with typing all specimens, a triage approach would require testing fewer specimens, but a greater reduction in HPV prevalence or a larger group of specimens would be needed to detect vaccine impact. Further investigation is warranted to inform type‐specific HPV monitoring approaches around the world.
Measures and metrics of sustainable diets with a focus on milk, yogurt, and dairy products

Abstract The 4 domains of sustainable diets are nutrition, economics, society, and the environment. To be sustainable, foods and food patterns need to be nutrient-rich, affordable, culturally acceptable, and sparing of natural resources and the environment. Each sustainability domain has its own measures and metrics. Nutrient density of foods has been assessed through nutrient profiling models, such as the Nutrient-Rich Foods family of scores. The Food Affordability Index, applied to different food groups, has measured both calories and nutrients per penny (kcal/$). Cultural acceptance measures have been based on relative food consumption frequencies across population groups. Environmental impact of individual foods and composite food patterns has been measured in terms of land, water, and energy use. Greenhouse gas emissions assess the carbon footprint of agricultural food production, processing, and retail. Based on multiple sustainability metrics, milk, yogurt, and other dairy products can be described as nutrient-rich, affordable, acceptable, and appealing. The environmental impact of dairy farming needs to be weighed against the high nutrient density of milk, yogurt, and cheese as compared with some plant-based alternatives.
Complex functionality with minimal computation: Promise and pitfalls of reduced‐tracer ocean biogeochemistry models

Earth System Models increasingly include ocean biogeochemistry models in order to predict changes in ocean carbon storage, hypoxia, and biological productivity under climate change. However, state‐of‐the‐art ocean biogeochemical models include many advected tracers, that significantly increase the computational resources required, forcing a trade‐off with spatial resolution. Here, we compare a state‐of‐the art model with 30 prognostic tracers (TOPAZ) with two reduced‐tracer models, one with 6 tracers (BLING), and the other with 3 tracers (miniBLING). The reduced‐tracer models employ parameterized, implicit biological functions, which nonetheless capture many of the most important processes resolved by TOPAZ. All three are embedded in the same coupled climate model. Despite the large difference in tracer number, the absence of tracers for living organic matter is shown to have a minimal impact on the transport of nutrient elements, and the three models produce similar mean annual preindustrial distributions of macronutrients, oxygen, and carbon. Significant differences do exist among the models, in particular the seasonal cycle of biomass and export production, but it does not appear that these are necessary consequences of the reduced tracer number. With increasing CO2, changes in dissolved oxygen and anthropogenic carbon uptake are very similar across the different models. Thus, while the reduced‐tracer models do not explicitly resolve the diversity and internal dynamics of marine ecosystems, we demonstrate that such models are applicable to a broad suite of major biogeochemical concerns, including anthropogenic change. These results are very promising for the further development and application of reduced‐tracer biogeochemical models that incorporate “sub‐ecosystem‐scale” parameterizations.
Influence of a New “Call-Out Algorithm” for Management of Postoperative Pain and Its Side Effects on Length of Stay in Hospital: A Two-Centre Prospective Randomized Trial

Background We recently introduced the efficacy safety score (ESS) as a new “call-out algorithm” for management of postoperative pain and side effects. In this study, we report the influence of ESS recorded hourly during the first 8 hours after surgery on the mobility degree, postoperative nonsurgical complications, and length of hospital stay (LOS). Methods We randomized 1152 surgical patients into three groups for postoperative observation: (1) ESS group (n = 409), (2) Verbal Numeric Rate Scale (VNRS) for pain group (n = 417), and (3) an ordinary qualitative observation (Control) group (n = 326). An ESS > 10 or VNRS > 4 at rest or a nurse's observation of pain or adverse reaction to analgesic treatment in the Control group served as a “call-out alarm” for an anaesthesiologist. Results We found no significant differences in the mobility degree and number of postoperative nonsurgical complications between the groups. LOS was significantly shorter with 12.7 ± 6.3 days (mean ± SD) in the ESS group versus 14.2 ± 6.2 days in the Control group (P < 0.001). Conclusion Postoperative ESS recording in combination with the possibility to call upon an anaesthesiologist when exceeding the threshold score might have contributed to the reductions of LOS in this two-centre study. This trial is registered with NCT02143128.
It Is Not All about Single Nucleotide Polymorphisms: Comparison of Mobile Genetic Elements and Deletions in Listeria monocytogenes Genomes Links Cases of Hospital-Acquired Listeriosis to the Environmental Source

ABSTRACT The control of food-borne outbreaks caused by Listeria monocytogenes in humans relies on the timely identification of food or environmental sources and the differentiation of outbreak-related isolates from unrelated ones. This study illustrates the utility of whole-genome sequencing for examining the link between clinical and environmental isolates of L. monocytogenes associated with an outbreak of hospital-acquired listeriosis in Sydney, Australia. Comparative genomic analysis confirmed an epidemiological link between the three clinical and two environmental isolates. Single nucleotide polymorphism (SNP) analysis showed that only two SNPs separated the three human outbreak isolates, which differed by 19 to 20 SNPs from the environmental isolates and 71 to >10,000 SNPs from sporadic L. monocytogenes isolates. The chromosomes of all human outbreak isolates and the two suspected environmental isolates were syntenic. In contrast to the genomes of background sporadic isolates, all epidemiologically linked isolates contained two novel prophages and a previously unreported clustered regularly interspaced short palindromic repeat (CRISPR)-associated (Cas) locus subtype sequence. The mobile genetic element (MGE) profile of these isolates was distinct from that of the other serotype 1/2b reference strains and sporadic isolates. The identification of SNPs and clonally distinctive MGEs strengthened evidence to distinguish outbreak-related isolates of L. monocytogenes from cocirculating endemic strains.
In Your Shoes or Mine? Shifting From Other to Self Perspective Is Vital for Emotional Empathy

Emotional empathy—feeling another person’s affective states—entails simulating how one would feel in the same circumstance. Prior research has implicated the role of executive controls and shown a link between visuospatial perspective taking and personal disposition of empathy. No study has investigated how executive control processes involved in perspective shifting relate to emotional empathy. Incorporating a spatial perspective-taking task in a set switch paradigm, we investigated whether swiftly switching from the altercentric to the egocentric perspective is associated with heightened emotional empathy but not with accurate classification of low-level perceptual affective cues. Emotional empathy was measured by subjective ratings of arousal and the similarity of affective states with the target person when viewing photos of a person in an emotionally charged context. Cognitive empathy was measured by correct recognition of affective cues. Our results showed that executive controls in perspective shifting related to emotional empathy but not to cognitive empathy. Emotional empathy correlated negatively with the switch cost from the altercentric to the egocentric perspective and not vice versa. Faster switching from the altercentric to the egocentric perspective was associated with heightened emotional empathy. Moreover, the processing strategy did not moderate the association. Flexibility in perspective shifting, especially in regaining one’s own perspective after taking another person’s perspective, is critical for emotional empathy. To feel another person’s affective states, one should regain self-perspective after walking in the other person’s shoes.
Adaptive Synchronization for a Class of Uncertain Fractional-Order Neural Networks

In this paper, synchronization for a class of uncertain fractional-order neural networks subject to external disturbances and disturbed system parameters is studied. Based on the fractional-order extension of the Lyapunov stability criterion, an adaptive synchronization controller is designed, and fractional-order adaptation law is proposed to update the controller parameter online. The proposed controller can guarantee that the synchronization errors between two uncertain fractional-order neural networks converge to zero asymptotically. By using some proposed lemmas, the quadratic Lyapunov functions are employed in the stability analysis. Finally, numerical simulations are presented to confirm the effectiveness of the proposed method.
Differential expression of various clones of estrogen receptor in cell block preparation of lung adenocarcinoma

Women treated for breast cancer are at increased risk of developing pulmonary nodules which could represent new primary lung carcinomas or metastatic breast carcinoma. The FNA biopsy is frequently the first diagnostic choice in determining the primary site of the tumor. Estrogen receptor (ER) positivity in diagnostic tissue is generally used to favor breast over lung primary. However, the recent studies have shown a wide range of ER antibody cross reactivity with lung adenocarcinoma. We studied the frequency of ER expression in cytology samples of lung adenocarcinoma using antibodies to three different ER clones.