Miracle-dz/UniFAR-FTUs huggingface dataset:
Infants' vocal engagement oriented towards mother versus stranger at 3 months and avoidant attachment behavior at 12 months

The aim of the present study was to demonstrate that mother avoidance in infants at the age of 12 months can be predicted by the infants' differential vocal engagement to mother versus a female stranger at the age of 3 months. Differential engagement in favor of the mother was supposed to relate to low future avoidance. The vocal behavior of 26 infants was assessed during face-to-face interactions with their mothers and with a strange woman at the age of 3 months. Differential vocal engagement was measured in terms of the time difference the infants spent vocalizing during eye contact with mother and stranger. At the age of 12 months avoidance of the mother was assessed during the reunion episodes of Ainsworth's Strange Situation. The result confirmed the assumption. Differential engagement in 3-month-olds is discussed as an indicator of the early infant–mother relationship.
Molecular and Cellular Mechanisms Responsible for Cellular Stress and Low-grade Inflammation Induced by a Super-low Dose of Endotoxin*

Background: Low-grade endotoxemia is a risk factor for chronic non-resolving inflammatory diseases. Results: A super-low dose of LPS induces cellular stress, mitochondrial fission, and necroptosis. Conclusion: IRAK-1 is required for cellular and molecular events leading to mitochondrial fission and cellular necroptosis. Significance: This study reveals novel mechanisms responsible for cellular stress, necroptosis, and low-grade inflammation associated with low-grade endotoxemia. Super-low-dose endotoxemia in experimental animals and humans is linked to low-grade chronic inflammatory diseases. However, the underlying molecular and cellular mechanisms are not well understood. In this study, we examined the effects of a super-low dose of LPS on low-grade inflammation in macrophages as well as underlying mechanisms. We observed that a super-low dose of LPS induces mitochondrial fission and cell necroptosis in primary murine macrophages, dependent upon interleukin 1 receptor-associated kinase (IRAK-1). Mechanistically, our study reveals that a super-low dose of LPS causes protein ubiquitination and degradation of mitofusin 1 (Mfn1), a molecule required for maintaining proper mitochondrial fusion. A super-low dose of LPS also leads to dephosphorylation and activation of Drp1, a molecule responsible for mitochondrial fission and cell necroptosis. Furthermore, we demonstrated that a super-low dose of LPS activates receptor interacting protein 3 kinase (RIP3), a key molecule critical for the assembly of the necrosome complex, the initiation of Drp1 dephosphorylation, and necroptosis. The effects of a super-low dose of LPS are abolished in macrophages harvested from IRAK-1-deficient mice. Taken together, our study identified a novel molecular pathway that leads to cellular stress and necroptosis in macrophages challenged with a super-low dose of endotoxin. This may reconcile low-grade inflammation often associated with low-grade endotoxemia.
Characteristics of Programs That Maximize Psychology Major Success

We conducted a national survey of psychology department chairs, and, based on their responses, we concluded that psychology programs differ in the number of students enrolled in various types of classes; the degree of focus on each of the goals recommended by the American Psychological Association (APA) Guidelines for an Undergraduate Psychology Education; the frequency of student participation in research, study abroad, and field placement; and the frequency of student–faculty interactions. We describe the percentage of psychology majors who have these program-relevant experiences. We also demonstrate that there are relationships between key high-impact activities and graduate school attendance, assessment test scores, and program completion rate. Based on the findings, we suggest how psychology programs may be able to help students to maximize their success.
An improved method for primary culture of normal cervical epithelial cells and establishment of cell model in vitro with HPV‐16 E6 gene by lentivirus

Normal human cervical epitheliums infected with HPVs gene in vitro are underlying molecular models to investigate physiological mechanisms of cervical epithelia and cervical disease. The current study aimed to establish a modified culture method for cervical epithelium and explore the feasibility of transfection with HPV‐16 E6 gene mediated by lentivirus in primary cervical cells. The cells were dissociated enzymatically using Dispase II combined with 0.25% Trypsin–0.01% ethylenediamine tetracetic acid (EDTA) or Collagenase I. The detached effectiveness of Dispase II at different times was compared. Isolated cells were cultured and subcultured in modified keratinocyte serum‐free medium (K‐SFM) supplemented with 5% fetal bovine serum (FBS) or K‐SFM alone. Cytokeratin was used as the identification of cervical epitheliums. Proliferative capacity and growth curve of cervical epitheliums were evaluated by cell counting kit‐8 (CCK‐8). The cells at passages 3 were used to infect with HPV‐16 E6 gene by lentivirus. The expression of green fluorescent protein (GFP) presented in the infected cells was observed via fluorescence microscopy and the levels of E6 mRNA were detected by quantitative real‐time PCR (qRT‐PCR). The results indicate that cervical epithelial cells can be isolated successfully by Dispase II combined with 0.25% Trypsin–0.01% EDTA method for 20 hr and maintained for five or six passages in K‐SFM medium with 5% FBS. The present study proposed a brief and high‐yield protocol for isolation and culture of human cervical epitheliums. Moreover, an infected cell model with HPV‐16 E6 gene mediated by lentivirus was established which can do duty for studies in vitro on the carcinogenic mechanism of HR‐HPVs.
Research assessment and the production of geographical knowledge

This Forum examines the research assessment systems (RASs) that affect professional human geography, and offers perspectives on the whole idea of formal research assessment. The Forum aims to assist professional geographers in their reflections on present and future research assessment in their own countries. It comprises two parts. The first offers highly succinct and detailed descriptions of the RASs currently in place in a range of countries -be they highly centralized, standardized and formal systems, or devolved and relatively informal ones. Many professional geographers know little about the assessment procedures outside their own countries and the first part allows a comparative understanding to be developed. The second part (‘Whither research assessment? ’) offers reflections on the whole notion of research assessment beyond the ‘normal’ assessment offered by peer review of papers, books and chapters; considers whether actually existing systems of research assessment in one or more countries embody the values conducive to an ‘appropriate’ form of research assessment; and it also considers the actual or probable impacts on the content and form of geographical knowledge of real or possible RASs.
INFLUÊNCIA DO GOLEIRO-LINHA NO RESULTADO DO JOGO DE FUTSAL

Influence of goalkeeper-line results in the game Futsal Introduction: After years the Futsal it suffered alterations in its rules, the main one of them is the one that says respect to the goalkeeper, taking it it a tactical evolution, becoming it a fifth player of line. Used to create a numerical advantage on the adversary. Objective: This article has the purpose to answer which the influence of the goalkeeper-line in the departure of Futsal, if it intervenes or not with the result of the game. Revision of literature: Had this alteration of rule to be recent, we do not find many references that dealt with the subject goalkeeper-line. The great part of the joined material was in periodic in "sites" in the Internet. Materials and methods: We break then for an analysis of games, creating one table of notations that quantified the participation of the goalkeeper-line and its effectiveness. Results: In the observed games we notice direct participation of the goalkeeper-line in the result of the departures, therefore they had happened goals through this resource. Quarrel: The action of the goalkeeper-line intervened with the departures, the teams that had needed and used this plan of game, had obtained goals at the moment that needed. With exception of the Russian team, that in disorganized way and with score of two goals against, did not get success. Conclusion: An attention of the professionals of this sport is necessary, for a previous preparation of its future athletes, how much to this system of game. Creating specific training for the function of the goalkeeper-line and defensive movements them teams when to play against this system of game.
The α-TIF (VP16) Homologue (ETIF) of Equine Herpesvirus 1 Is Essential for Secondary Envelopment and Virus Egress

ABSTRACT The equine herpesvirus 1 (EHV-1) α-trans-inducing factor homologue (ETIF; VP16-E) is a 60-kDa virion component encoded by gene 12 (ORF12) that transactivates the immediate-early gene promoter. Here we report on the function of EHV-1 ETIF in the context of viral infection. An ETIF-null mutant from EHV-1 strain RacL11 (vL11ΔETIF) was constructed and analyzed. After transfection of vL11ΔETIF DNA into RK13 cells, no infectious virus could be reconstituted, and only single infected cells or small foci containing up to eight infected cells were detected. In contrast, after transfection of vL11ΔETIF DNA into a complementing cell line, infectious virus could be recovered, indicating the requirement of ETIF for productive virus infection. The growth defect of vL11ΔETIF could largely be restored by propagation on the complementing cell line, and growth on the complementing cell line resulted in incorporation of ETIF in mature and secreted virions. Low- and high-multiplicity infections of RK13 cells with phenotypically complemented vL11ΔETIF virus resulted in titers of virus progeny similar to those used for infection, suggesting that input ETIF from infection was recycled. Ultrastructural studies of vL11ΔETIF-infected cells demonstrated a marked defect in secondary envelopment at cytoplasmic membranes, resulting in very few enveloped virions in transport vesicles or extracellular space. Taken together, our results demonstrate that ETIF has an essential function in the replication cycle of EHV-1, and its main role appears to be in secondary envelopment.
Stability of kinetochore‐microtubule attachment and the role of different KMN network components in Drosophila

Kinetochores bind spindle microtubules and also act as signaling centers that monitor this interaction. Defects in kinetochore assembly lead to chromosome missegregation and aneuploidy. The interaction between microtubules and chromosomes involves a conserved super‐complex of proteins, known as the KNL1Mis12Ndc80 (KMN) network, composed by the KNL1 (Spc105), Mis12, and Ndc80 complexes. Previous studies indicate that all components of the network are required for kinetochore‐microtubule attachment and all play relevant functions in chromosome congression, biorientation, and segregation. Here, we report a comparative study addressing the role of the different KMN components using dsRNA and in vivo fluorescence microscopy in Drosophila S2 cells allowing us to suggest that different KMN network components might perform different roles in chromosome segregation and the mitotic checkpoint signaling. Depletion of different components results in mostly lateral kinetochore‐microtubule attachments that are relatively stable on depletion of Mis12 or Ndc80 but very unstable after Spc105 depletion. In vivo analysis on depletion of Mis12, Ndc80, and to some extent Spc105, shows that lateral kinetochore‐microtubule interactions are still functional allowing poleward kinetochore movement. We also find that different KMN network components affect differently the localization of spindle assembly checkpoint (SAC) proteins at kinetochores. Depletion of Ndc80 and Spc105 abolishes the mitotic checkpoint, whereas depletion of Mis12 causes a delay in mitotic progression. Taken together, our results suggest that Mis12 and Ndc80 complexes help to properly orient microtubule attachment, whereas Spc105 plays a predominant role in the kinetochore‐microtubule attachment as well as in the poleward movement of chromosomes, SAC response, and cell viability. © 2013 Wiley Periodicals, Inc.
Quality of life among multiple sclerosis patients in Saudi Arabia

Objective: To assess quality of life in multiple sclerosis (MS) patients and determine the factors associated with levels of quality of life in MS patients in a public hospital in Saudi Arabia. Methods: A cross-sectional study was conducted from June 2016 to April 2017 in King Abdulaziz Medical City, Jeddah, Kingdom of Saudi Arabia. Multiple sclerosis patients attending the outpatient and inpatient services were approached and recruited to participate in the study. The Arabic version of EuroQOL-5 Dimensions instrument (EQ-5D) was utilized for the assessment of MS patients quality of life. Results: Data on quality of life were obtained from 292 patients. The reported quality of life of MS patients as measured by the EQ-5D index value score was 0.31±0.51 and the EQ-VAS score was 73.87±23.41, respectively. It was found that quality of life determined numerically in the EQ-5D index value and EQ-VAS deteriorates proportionally according to the disease duration. Conclusion: Multiple sclerosis is associated with a considerable effect on the patients quality of life. It continues to be challenging to manage both medically and psychosocially. Clinicians should consider the assessment of quality of life as routine practice along with the other important measures including symptomatic evaluation, laboratory tests, and neuroimaging to provide a holistic care of their MS patients.
RSS-based Monte Carlo localisation for mobile sensor networks

Node localisation is a fundamental problem in wireless sensor networks. Many applications require the location information of sensor nodes. Received signal strength (RSS) is a simple and inexpensive approach for localisation purpose. However, the accuracy of RSS measurement is unpredictable owing to the nature of the radio frequency (RF) channel. An RSS-based Monte Carlo localisation scheme is proposed to sequentially estimate the location of mobile nodes, using the log-normal statistical model of RSS measurement. The RSS measurement is treated as the observation model in Monte Carlo method and the mobility feature of nodes as the transition model. Our method is widely applicable because the RSS function is easy to implement on nodes, and the mathematical model for mobile nodes may have non-analytic forms. Simulation results about localisation accuracy and cost show that this scheme is better than other methods.
The effects of structural consistency on attitude-intention and attitude-behavior relationships

The effects of structural consistency including affective-cognitive consistency (ACC) and attitude based on attitude-intention consistency (AIC) and attitude-behavior consistency (ABC) were explored. Results revealed the effect of ACC on attitude-intention consistency and the interaction of ACC and attitude based on attitude-behavior consistency. Specifically, an attitude with high ACC led to stronger intention. Regarding the attitude-behavior relation, cognitive-focus attitude with high ACC was a more reliable predictor of behavior, whereas affective-focus attitude predicted behavior equally in high and low ACC conditions.
Hemangiomas and Vascular Malformations: Current Theory and Management

Vascular anomalies are a heterogeneous group of congenital blood vessel disorders more typically referred to as birthmarks. Subcategorized into vascular tumors and malformations, each anomaly is characterized by specific morphology, pathophysiology, clinical behavior, and management approach. Hemangiomas are the most common vascular tumor. Lymphatic, capillary, venous, and arteriovenous malformations make up the majority of vascular malformations. This paper reviews current theory and practice in the etiology, diagnosis, and treatment of these more common vascular anomalies.
Process Integration of Co-Sputtered Bismuth Telluride/Antimony Telluride Thermoelectric Junctions

Incorporation of bismuth telluride/antimony telluride co-sputtered thermoelectric junctions into MEMS devices requires process developments for patterning and encapsulation as well as characterization of properties such as film stress and contact resistance. Test structures are presented for measuring important thermoelectric properties, resistivity, thermal conductivity, carrier concentration, and Seebeck coefficient. A fabrication process is presented that allows the junctions to be deposited, patterned, encapsulated, and etch released. Measurement of the thermoelectric junctions reveals a room temperature figure of merit, ZT, of 0.43 with a total Seebeck coefficient difference of 150 μV/K, resistivities of 17.4 and 7.6 μΩ-m, and thermal conductivity of 0.34 and 0.30 W/mK for antimony telluride and bismuth telluride, respectively. The junctions have been incorporated into state of the art uncooled thermopile infrared detectors with a peak detectivity of 3 × 109 cm*Hz1/2/W.
Insulin-like growth factor I promotes growth selectively in fetal sheep in late gestation.

Insulin-like growth factor I (IGF-I) is required for normal fetal growth and skeletal maturation in late gestation, because null mutations of the IGF-I gene in mice reduce fetal weight and retard ossification of bones. To determine if, conversely, increased abundance of IGF-I promotes fetal growth and skeletal maturation, fetal sheep were infused intravascularly with recombinant human IGF-I (n = 7) (26 +/- 3 micrograms. h-1.kg-1) from 120 to 130 days gestation and compared with controls (n = 15). IGF-I infusion increased plasma IGF-I concentrations by 140% (P = 0.002) and weights of fetal liver, lungs, heart, kidneys, spleen, pituitary, and adrenal glands by 16-50% (P < 0.05). Weights and/or lengths of the fetus, placenta, gastrointestinal tract, individual skeletal muscles, and long bones were unchanged by IGF-I. However, IGF-I increased the percentage of proximal epiphyses of long bones present (P < 0.05) and their cross-sectional areas by 15 to 38% (P < 0.05). These results show that IGF-I promotes growth of major fetal organs, endocrine glands, and skeletal maturation in vivo, consistent with IGF-I actively controlling and not merely facilitating fetal growth. The variable response of different tissues may partly reflect tissue specificity in growth requirements for additional factors.
Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4

Abstract The novel insulin-secreting human pancreatic β-cell line, 1.1B4, demonstrates stability in culture and many of the secretory functional attributes of human pancreatic β-cells. This study investigated the cellular responses of 1.1B4 cells to lipotoxicity. Chronic 18-h exposure of 1.1B4 cells to 0.5 mm palmitate resulted in decreased cell viability and insulin content. Secretory responses to classical insulinotropic agents and cellular Ca2+ handling were also impaired. Palmitate decreased glucokinase activity and mRNA expression of genes involved in secretory function but up-regulated mRNA expression of HSPA5, EIF2A, and EIF2AK3, implicating activation of the endoplasmic reticulum stress response. Palmitate also induced DNA damage and apoptosis of 1.1B4 cells. These responses were accompanied by increased gene expression of the antioxidant enzymes SOD1, SOD2, CAT and GPX1. This study details molecular mechanisms underlying lipotoxicity in 1.1B4 cells and indicates the potential value of the novel β-cell line for future research.
Action et imagerie mentale chez l'enfant

This work extends comparative studies in children affected by Cerebral Palsy and non-affected children. The aim of this research is to examine the role of action in mental imagery processes in 5-6, 7-8 and 9-10 year-old able children. A mental rotation task was presented to the children. In one group, children handle the experimental device ; in the other group, the device was handled by the experimenter. The results suggest that action supports mental imagery processes at least until the age of 9-10 years. Mental imagery becomes independent from the concrete world about 9-10 years old, when a dynamic and flexible spatial thought is available to children.
Publish or Perish: Is this Really a Viable Set of Options?

Abstract This paper examines publishing patterns amongst Australian accounting academics over the period 1999–2003. The number of potential publications is estimated by reference to the existing academic staff, their status and qualifications. An estimate of 400 potential publications per year was calculated. This was compared with the actual output of the best-known Australian based accounting journals over the period 1999–2003, calculated at about 60 articles per year. Clearly, a sudden increase in output to the level that ought to be taking place would place a strain on the system. One possible method of recognising publishable research output, regardless of space available for the work to be published, would be for an independent ‘panel of referees’ to award the status of ‘worthy of publication in a learned journal’ to research output in order to assist the academic staff in gaining appropriate recognition and reward, avoiding the simple dichotomy that currently faces many academics to publish or to perish, making an on-line publication after review by a national body of referees an alternative journal publication.
“Vanilla Thrillas”: Modern Boxing and White-Ethnic Masculinity

From 2002 to 2004, Arturo Gatti and Micky Ward fought three boxing matches. The Ward—Gatti bouts produced a discourse that was never monolithic and oftentimes contradictory, yet many fight fans and journalists asserted that the match-ups hearkened back to a time when “White-ethnic” fighters ruled the ring. The manner in which these contests captured the imagination of even casual boxing fans revealed how modern conversations about race and masculinity operated not only within boxing circles but in American society as well. Though some critics charged that the fights were excessively violent, most boxing fans saw the contests as fantastic theater and urged the sport’s authorities to reward the pugilists. For White fans, the “vanilla thrillas” provided symbolic affirmations of collective masculinity that simultaneously indicated lingering racial resentments.
Updated Meta-Analysis on the Relationship Between Congruence and Satisfaction

This article reports on a replication meta-analysis of Holland’s congruence theory, which maps the relationship between vocational interests-vocational environments on one hand and satisfaction on the other. The replication is based on 26 studies reported between 1988 and 2003, representing 53 samples and 6,557 respondents. This meta-analysis also examines the effect of culture and age as moderating variables on the congruence-satisfaction relationship. The current replication found no support for the moderating effect of others in the environment, satisfaction source, and code type, as reported by the previous meta-analysis. However, previous findings regarding the effect of congruence index as a moderator were confirmed. Moreover, this type of interest questionnaire was also found to be a moderating variable. The examination of the effects of culture yielded differences between studies conducted in the United States and Israel. Some support was also found for age as a moderating variable. Recommendations for future research are suggested.