Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential and directional effects of perfusion on electrical and thermal conductivities in liver

Two different measurement probes - an electrical probe and a thermal conductivity probe - were designed, fabricated, calibrated, and used in experimental studies on a pig liver model that was designed to control perfusion rates. These probes were fabricated by photolithography and mounted in 1.5-mm diameter catheters. We measured the local impedance and thermal conductivity, respectively, of the artificially perfused liver at different flow rates and, by rotating the probes, in different directions. The results show that both the local electrical conductivity and the thermal conductivity varied location to location, that thermal conductivity increased with decreased distance to large blood vessels, and that significant directional differences exist in both electrical and thermal conductivities. Measurements at different perfusion rates demonstrated that both the local electrical and local thermal conductivities increased linearly with the square root of perfusion rate. These correlations may be of great value to many energy-based biomedical applications.
The Sesquiterpenes(E)-ß-Farnesene and (E)-α-Bergamotene Quench Ozone but Fail to Protect the Wild Tobacco Nicotiana attenuata from Ozone, UVB, and Drought Stresses

Among the terpenes, isoprene (C5) and monoterpene hydrocarbons (C10) have been shown to ameliorate abiotic stress in a number of plant species via two proposed mechanisms: membrane stabilization and direct antioxidant effects. Sesquiterpene hydrocarbons (C15) not only share the structural properties thought to lend protective qualities to isoprene and monoterpene hydrocarbons, but also react rapidly with ozone, suggesting that sesquiterpenes may similarly enhance tolerance of abiotic stresses. To test whether sesquiterpenes protect plants against ozone, UVB light, or drought, we used transgenic lines of the wild tobacco Nicotiana attenuata. The transgenic plants expressed a maize terpene synthase gene (ZmTPS10) which produced a blend of (E)-ß-farnesene and (E)-α-bergamotene, or a point mutant of the same gene (ZmTPS10M) which produced (E)-ß-farnesene alone,. (E)-ß-farnesene exerted a local, external, and transient ozone-quenching effect in ozone-fumigated chambers, but we found no evidence that enhanced sesquiterpene production by the plant inhibited oxidative damage, or maintained photosynthetic function or plant fitness under acute or chronic stress. Although the sesquiterpenes (E)-ß-farnesene and (E)-α-bergamotene might confer benefits under intermittent heat stress, which was not tested, any roles in relieving abiotic stress may be secondary to their previously demonstrated functions in biotic interactions.
Requirement of Intact Adenosine A1 Receptors for the Diuretic and Natriuretic Action of the Methylxanthines Theophylline and Caffeine

Although the diuretic and natriuretic effects of the methylxanthines caffeine and theophylline are well established, the mechanisms responsible for these effects are unclear and may be related to inhibition of phosphodiesterases and/or antagonism of adenosine receptors. With regard to the latter, pharmacological blockade of A1 receptors can induce diuresis and natriuresis by inhibition of proximal tubular reabsorption. To elucidate the role of the A1 receptor in renal actions of methylxanthines, experiments were performed in A1 receptor knockout (A1R-/-) and littermate wild-type (A1R+/+) mice. Urinary excretion was determined in awake mice in metabolic cages over 3 h in response to theophylline (as theophylline2/ethylenediamine, 45 mg/kg), caffeine (45 mg/kg), or vehicle (0.9 ml/30 g b.wt. of 0.85% NaCl) given by oral gavage. Theophylline and caffeine elicited a diuresis and natriuresis (in absolute terms and related to urinary creatinine excretion) in A1R+/+ but not in A1R-/- mice. In a second series, the renal effect of intravenous application of theophylline (30 mg/kg) was determined in clearance experiments under anesthesia. This study revealed that the blunted diuretic and natriuretic effect of theophylline in A1R-/- mice was not due to different responses in blood pressure or glomerular filtration rate. The data indicate that an intact A1 receptor is necessary for caffeine- and theophylline-induced inhibition of renal reabsorption causing diuresis and natriuresis. This is consistent with the assumption that A1 receptor blockade mediates these effects.
Induction of Anti-Glioma Natural Killer Cell Response following Multiple Low-Dose Intracerebral CpG Therapy

Purpose: Stimulation of toll-like receptor-9 by CpG oligodeoxynucleotides (CpG-ODN) has been shown to counteract the immunosuppressive microenvironment and to inhibit tumor growth in glioma models. These studies, however, have used high doses of CpG-ODN, which can induce toxicity in a clinical setting. The goal of this study was to evaluate the antitumor efficacy of multiple low-dose intratumoral CpG-ODN in a glioma model. Experimental Design: Mice bearing 4-day-old intracranial GL261 gliomas received a single or multiple (two or four) intratumoral injections of CpG-ODN (3 μg) every 4 days. Tumor growth was measured by bioluminescent imaging, brain histology, and animal survival. Flow cytometry and cytotoxicity assays were used to assess anti-glioma immune response. Results: Two and four intracranial injections of low-dose CpG-ODN, but not a single injection, eradicated gliomas in 70% of mice. Moreover, surviving animals exhibited durable tumor-free remission (> 3 months) and were protected from intracranial rechallenge with GL261 gliomas, showing the capacity for long-term antitumor immunity. Although most inflammatory cells seemed to increase, activated natural killer (NK) cells (i.e., NK+CD107a+) were more frequent than CD8+CD107a+ in the brains of rechallenged CpG-ODN–treated animals and showed a stronger in vitro cytotoxicity against GL261 target cells. Leukocyte depletion studies confirmed that NK cells played an important role in the initial CpG-ODN antitumor response, but both CD8 and NK cells were equally important in long-term immunity against gliomas. Conclusions: These findings suggest that multiple low-dose intratumoral injections of CpG-ODN can eradicate intracranial gliomas possibly through mechanisms involving NK-mediated effector function. Clin Cancer Res; 16(13); 3399–408. ©2010 AACR.
An In Vitro ES Cell-Based Clock Recapitulation Assay Model Identifies CK2α as an Endogenous Clock Regulator

We previously reported emergence and disappearance of circadian molecular oscillations during differentiation of mouse embryonic stem (ES) cells and reprogramming of differentiated cells, respectively. Here we present a robust and stringent in vitro circadian clock formation assay that recapitulates in vivo circadian phenotypes. This assay system first confirmed that a mutant ES cell line lacking Casein Kinase I delta (CKIδ) induced ∼3 hours longer period-length of circadian rhythm than the wild type, which was compatible with recently reported results using CKIδ null mice. In addition, this assay system also revealed that a Casein Kinase 2 alpha subunit (CK2α) homozygous mutant ES cell line developed significantly longer (about 2.5 hours) periods of circadian clock oscillations after in vitro or in vivo differentiation. Moreover, revertant ES cell lines in which mutagenic vector sequences were deleted showed nearly wild type periods after differentiation, indicating that the abnormal circadian period of the mutant ES cell line originated from the mutation in the CK2α gene. Since CK2α deficient mice are embryonic lethal, this in vitro assay system represents the genetic evidence showing an essential role of CK2α in the mammalian circadian clock. This assay was successfully applied for the phenotype analysis of homozygous mutant ES cells, demonstrating that an ES cell-based in vitro assay is available for circadian genetic screening.
A Biomechanical Analysis of the Squat Between Competitive Collegiate, Competitive High School, and Novice Powerlifters

Miletello, WM, Beam, JR, and Cooper, ZC. A biomechanical analysis of the squat between competitive collegiate, competitive high school, and novice powerlifters. J Strength Cond Res 23(5): 1611-1617, 2009-The purpose of this study was to measure and analyze kinematic differences between competitive collegiate (CLG, n = 9) powerlifters, competitive high school (HS, n = 9) powerlifters, and novice (NV, n = 11) powerlifters during a maximal squat to determine the effect of skill level on performance. All powerlifters performed 3 squats, with the final squat being their 1 repetition maximum. Kinematic data (descent, ascent, total lift times, knee angle magnitude, knee angular velocity, and knee angular acceleration) was measured using 2-dimensional motion analysis equipment. Differences in mean peak kinematic values between the 3 groups were analyzed using a 1-way multivariate analysis of variance, p ≤ 0.05. Differences were found between the NV and HS in the time to ascent, the total lift time, the normalized time to peak (NTTP) in knee angular velocity from the “sticking point” to the “lockout,” and the NTTP in knee angular acceleration during the ascent. A difference was found between the CLG and HS in the peak knee angular velocity between the bottom of the lift and the sticking point. Differences were also found in the rate of acceleration upward after coming out of “the hole” between the CLG and NV and CLG and HS. A difference was found in the rate of peak deceleration upward to the sticking point between the CLG and NV. To avoid injury and to achieve optimum results in powerlifting, lifting technique must be optimized. The HS and NV accumulated several significant differences in NTTP during the ascending phase. However, the major finding between the 3 groups was in the rate of acceleration upward after coming out of the hole. Coaches should focus their training programs on increasing strength in unskilled powerlifters for the purpose of increasing acceleration from the bottom of the lift.
About learning: report of the Learning Working Group

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Trauma, Depression, Anxiety, and Stress among Individuals Living in Earthquake Affected and Unaffected Areas

Earthquake of 8th October 2005 affected many regions in Pakistan. After about a year of the earthquake trauma, depression, anxiety, and stress were studied among 600 individuals (300 from the three earthquake affected areas and a comparable number from three unaffected areas). Urdu translated version of Impact of Event Scale (Aslam, 2007); Urdu translated version of Depression, Anxiety, Stress Scale (Aslam, 2007); and Ego-resiliency Scale (Nangiana, 2002) were used. Significant differences were observed between participants of affected and unaffected areas on all the variables studied. In affected areas, married individuals scored significantly higher on the variables of trauma, depression, and stress as compared to unmarried individuals and women scored higher on the variable of stress as compared to men. The construct of ego-resiliency explained its inverse relationship with the levels of PTSD, depression, anxiety, and stress observed among individuals living in affected and unaffected areas. Practical implications were discussed and suggestions for future research were made.
Employee recognition at work : a study of employee experiences

Despite evidence of its increasingly widespread use within organisations and a significant body of practitioner and “popular” literature on the subject, employee recognition has received relatively little empirical study by academic researchers. As a result, there are significant gaps in our knowledge, particularly around how recognition schemes actually operate in organisations and the ways in which they impact upon individuals and organisations. This thesis responds to these knowledge gaps through presenting empirical evidence collected through in-depth interviews with employees drawn from two organisations, an insurance company and a local council, about their experiences of recognition in the workplace. Taking an inductive thematic approach to the analysis of the employees’ accounts, I identify some of the key factors influencing employees’ experiences of recognition, thus contributing to knowledge about how recognition schemes are experienced and understood by employees. In particular, I highlight the importance of the social and organisational context in which recognition is given and received in influencing the meanings which individuals assign to recognition. I also discuss the ways in which further factors such as the recognition scheme design and implementation, including the way in which recognition is delivered to recipients, can mediate individuals’ experiences of recognition. Drawing upon theories of gift giving, I offer interpretations of employees’ accounts of their recognition experiences which identify three main important social functions fulfilled by employee recognition: the communication of information about the perceptions and intentions of individuals involved in the process of recognition, the development and maintenance of social exchange relationships between individuals in the workplace, and the promotion of a sense of solidarity and unity within the organisation. Furthermore, whilst offering insights into its possible positive social functions and implications, this thesis contributes to knowledge about employee recognition by drawing attention to its possible dysfunctional consequences. The findings of this thesis are useful for practitioners responsible for designing and implementing employee recognition schemes, as well as for academic researchers seeking to understand the underlying dynamics of employee recognition as a human resource management practice.
Sparkling Fountains or Stagnant Ponds: An Integrative Model of Creativity and Innovation Implementation in Work Groups

In this article I synthesise research and theory that advance our understanding of creativity and innovation implementation in groups at work. It is suggested that creativity occurs primarily at the early stages of innovation processes with innovation implementation later. The influences of task characteristics, group knowledge diversity and skill, external demands, integrating group processes and intragroup safety are explored. Creativity, it is proposed, is hindered whereas perceived threat, uncertainty or other high levels of demands aid the implementation of innovation. Diversity of knowledge and skills is a powerful predictor of innovation, but integrating group processes and competencies are needed to enable the fruits of this diversity to be harvested. The implications for theory and practice are also explored.
TiO2 Immobilized on Manihot Carbon: Optimal Preparation and Evaluation of Its Activity in the Decomposition of Indigo Carmine

Applications of carbon-TiO2 materials have attracted attention in nanotechnology due to their synergic effects. We report the immobilization of TiO2 on carbon prepared from residues of the plant Manihot, commercial TiO2 and glycerol. The objective was to obtain a moderate loading of the anatase phase by preserving the carbonaceous external surface and micropores of the composite. Two preparation methods were compared, including mixing dry precursors and immobilization using a glycerol slurry. The evaluation of the micropore blocking was performed using nitrogen adsorption isotherms. The results indicated that it was possible to use Manihot residues and glycerol to prepare an anatase-containing material with a basic surface and a significant SBET value. The activities of the prepared materials were tested in a decomposition assay of indigo carmine. The TiO2/carbon eliminated nearly 100% of the dye under UV irradiation using the optimal conditions found by a Taguchi L4 orthogonal array considering the specific surface, temperature and initial concentration. The reaction was monitored by UV-Vis spectrophotometry and LC-ESI-(Qq)-TOF-MS, enabling the identification of some intermediates. No isatin-5-sulfonic acid was detected after a 60 min photocatalytic reaction, and three sulfonated aromatic amines, including 4-amino-3-hydroxybenzenesulfonic acid, 2-(2-amino-5-sulfophenyl)-2-oxoacetic acid and 2-amino-5-sulfobenzoic acid, were present in the reaction mixture.
Alterations in corticotropin-releasing factor and vasopressin content in rat brain during morphine withdrawal: correlation with hypothalamic noradrenergic activity and pituitary-adrenal response.

The modification in the activity of noradrenergic neurons projecting to the hypothalamus and the pituitary-adrenal response during morphine withdrawal as well its correlation with alterations in corticotropin-releasing factor (CRF) and vasopressin (AVP) content in different brain areas was analyzed. Male rats were implanted with placebo (naïve) or morphine (tolerant/dependent) pellets for 7 days. On day 8, groups of rats received an acute injection of saline s.c. (control) or naloxone (1 mg/kg s.c.) and were decapitated 30 min later. After administration of naloxone to tolerant rats (withdrawal) we found a striking parallelism between an enhanced activity of hypothalamic noradrenergic neurons and an increased corticosterone secretion; concomitantly, the CRF but not the AVP content in the paraventricular nucleus was decreased, which might reflect an increased release of the peptide. During withdrawal, CRF content also was decreased in the arcuate nucleus, whereas no changes were found in the median eminence, dorsomedial, ventromedial nuclei or in the bed nucleus of the stria terminalis. AVP content levels were not modified in arcuate nucleus, supraoptic or in the suprachiasmatic nuclei. Present data suggest that a hypothalamic noradrenergic hypersecretion may be involved in a selectively increased activity of CRF neurons in the paraventricular nucleus and arcuate nucleus and then in the enhanced release of corticosterone induced by morphine withdrawal. However, we did not find any correlation between opioid withdrawal-induced alterations in the pituitary-adrenal axis and AVP modifications.
Analyzing Framing through the Casts of Characters in the News

We present an unsupervised model for the discovery and clustering of latent “personas” (characterizations of entities). Our model simultaneously clusters documents featuring similar collections of personas. We evaluate this model on a collection of news articles about immigration, showing that personas help predict the coarse-grained framing annotations in the Media Frames Corpus. We also introduce automated model selection as a fair and robust form of feature evaluation.
La contingence des systèmes de mesure de la performance: les résultats d’une recherche empirique sur le secteur des PME

(VF)A partir des resultats d’une enquete realisee aupres de 83 entreprises, cet article montre que les systemes de mesure de la performance des PME n’adoptent pas, dans la majorite des cas, la structure «equilibree» du Balanced Scorecard. La mesure de la performance tend a devenir plus «equilibree» lorsque la taille de l’entreprise augmente et lorsque l’ environnement organisationnel est complexe et incertain. (VA) This article contains empirical evidence based on a postal survey of 83 firms, and shows that, in small and medium-size business, performance measurement systems do not usually apply the balanced scorecard framework. Increasing firm size as well as environmental complexity and uncertainty are identified as factors which tend to foster a more balanced approach.
Attitudes Towards and Satisfaction with Cooperatives in Alberta: A Survey Analysis

The purpose of the study is to assess the attitude towards, and satisfaction of residents of Alberta to their cooperatives. A mailed questionnaire to 1500 Alberta residents, with a 16% response rate is analyzed using Likert scales and the theory of planned behavior. The majority of the respondents are males, aged 45 or older, and earn incomes of $49,000 or less. They are reasonably educated with a high school, college or university degrees. Results of the analysis also show a population that has a general positive attitude towards and is satisfied with their cooperatives as is reflected in assessing the performance of their cooperatives as good. Further analysis using the theory of planned behaviour show that respondents' attitude towards their cooperatives is the single most important and significant predictor of their patronization behaviour. However, there are still issues of concern to be addressed for current and past members. These include the inability of management to include members in the decision making process as well as issues of member training and education for the current members, and for the former members who left because they found the experience not rewarding or unable to use the services of their cooperatives when they moved.