Miracle-dz/UniFAR-FTUs huggingface dataset:
DeepFaceLIFT: Interpretable Personalized Models for Automatic Estimation of Self-Reported Pain

Previous research on automatic pain estimation from facial expressions has focused primarily on "one-size-fits-all" metrics (such as PSPI). In this work, we focus on directly estimating each individual's self-reported visual-analog scale (VAS) pain metric, as this is considered the gold standard for pain measurement. The VAS pain score is highly subjective and context-dependent, and its range can vary significantly among different persons. To tackle these issues, we propose a novel two-stage personalized model, named DeepFaceLIFT, for automatic estimation of VAS. This model is based on (1) Neural Network and (2) Gaussian process regression models, and is used to personalize the estimation of self-reported pain via a set of hand-crafted personal features and multi-task learning. We show on the benchmark dataset for pain analysis (The UNBC-McMaster Shoulder Pain Expression Archive) that the proposed personalized model largely outperforms the traditional, unpersonalized models: the intra-class correlation improves from a baseline performance of 19\% to a personalized performance of 35\% while also providing confidence in the model\textquotesingle s estimates -- in contrast to existing models for the target task. Additionally, DeepFaceLIFT automatically discovers the pain-relevant facial regions for each person, allowing for an easy interpretation of the pain-related facial cues.
A Comparison of Different Pre-Performance Routines as Possible Choking Interventions

The purpose of the current study was to ascertain which aspect of a pre-performance routine (PPR) is most beneficial to alleviate choking. Participants included 60 experienced Australian football players in Australia, who attempted 20 kicks at a scoring zone in low- and high-pressure phases. Participants were assigned to one of five groups, with four groups undertaking intervention training and the pressure control group receiving no training, prior to the high-pressure phase. Results indicated that state anxiety increased during the high-pressure phase. Intervention groups responded to the increased anxiety with improved performance, while the pressure control group decreased performance. Thus, results add support to existing literature that a non-automated PPR, with psychological and behavioral components, decreases the likelihood of choking. Applied implications for consulting with potential choking-susceptible athletes are discussed.
Mother Nature Has It Right: Local Food Advocacy and the Appeal to the “Natural”

Local food advocacy is a political and moral discourse that is meant to provide the foundation for understanding local food networks as sites of resistance against the norms and power of globalized industrial food-ways. In this context, the concept of the “natural” is frequently and un-critically invoked to argue for the ethical significance of participating in and advocating for local food networks. I argue that the conception of the “natural” at work is unquestioningly purity-based and is consistent with the construction of “nature” under traditional value dualism. This is problematic in that the dualistic framework serves to obscure many actual complexities within the “natural” and the “local” themselves, and in their relationships with their counterparts, the “cultural” and the “global. ” Thus by leaving unquestioned certain assumptions about the meaning of the “natural” and how that meaning was constructed, local food advocacy is not as resistant as it might otherwise be. I suggest that local food advocates ought to utilize ecological and transnational feminist tools that are better able to acknowledge the complex and ever-changing character of the “natural” and the “local. ”
Intergenerational Payoffs of Education

Better-educated parents generally have children who are themselves better educated, healthier, wealthier, and better off in almost every way than the children of the less educated. But this simple correlation does not prove that the relationship is causal. Neeraj Kaushal sifts through the evidence from economics and public policy and reviews large national and international studies to conclude that, indeed, education has large intergenerational payoffs in many areas of children’s lives, and that these payoffs persist over time. Kaushal shows that, if anything, traditional measures of returns to education—which focus on income and productivity—almost certainly underestimate the beneficial effects that parents’ education has on their children. She reports causal positive effects not only on children’s test scores, health, and behavior, but also on mothers’ behaviors that can affect their children’s wellbeing, such as teenage childbearing and substance use. Her findings suggest that, as a component of two-generation programs, helping parents extend their education could go a long way toward reducing inequality across generations and promoting children’s healthy development. Thus the rationale for two-generation programs that boost parents’ education is compelling. However, Kaushal cautions, the U.S. education system reinforces socioeconomic inequality across generations by spending more money on educating richer children than on educating poorer children. By themselves, then, two-generation programs will not necessarily ameliorate the structural factors that perpetuate inequality in this country.
Effects of Individual Health Topic Familiarity on Activity Patterns During Health Information Searches

Background Non-medical professionals (consumers) are increasingly using the Internet to support their health information needs. However, the cognitive effort required to perform health information searches is affected by the consumer’s familiarity with health topics. Consumers may have different levels of familiarity with individual health topics. This variation in familiarity may cause misunderstandings because the information presented by search engines may not be understood correctly by the consumers. Objective As a first step toward the improvement of the health information search process, we aimed to examine the effects of health topic familiarity on health information search behaviors by identifying the common search activity patterns exhibited by groups of consumers with different levels of familiarity. Methods Each participant completed a health terminology familiarity questionnaire and health information search tasks. The responses to the familiarity questionnaire were used to grade the familiarity of participants with predefined health topics. The search task data were transcribed into a sequence of search activities using a coding scheme. A computational model was constructed from the sequence data using a Markov chain model to identify the common search patterns in each familiarity group. Results Forty participants were classified into L1 (not familiar), L2 (somewhat familiar), and L3 (familiar) groups based on their questionnaire responses. They had different levels of familiarity with four health topics. The video data obtained from all of the participants were transcribed into 4595 search activities (mean 28.7, SD 23.27 per session). The most frequent search activities and transitions in all the familiarity groups were related to evaluations of the relevancy of selected web pages in the retrieval results. However, the next most frequent transitions differed in each group and a chi-squared test confirmed this finding (P<.001). Next, according to the results of a perplexity evaluation, the health information search patterns were best represented as a 5-gram sequence pattern. The most common patterns in group L1 were frequent query modifications, with relatively low search efficiency, and accessing and evaluating selected results from a health website. Group L2 performed frequent query modifications, but with better search efficiency, and accessed and evaluated selected results from a health website. Finally, the members of group L3 successfully discovered relevant results from the first query submission, performed verification by accessing several health websites after they discovered relevant results, and directly accessed consumer health information websites. Conclusions Familiarity with health topics affects health information search behaviors. Our analysis of state transitions in search activities detected unique behaviors and common search activity patterns in each familiarity group during health information searches.
In silico strain optimization by adding reactions to metabolic models

Summary Nowadays, the concerns about the environment and the needs to increase the productivity at low costs, demand for the search of new ways to produce compounds with industrial interest. Based on the increasing knowledge of biological processes, through genome sequencing projects, and high-throughput experimental techniques as well as the available computational tools, the use of microorganisms has been considered as an approach to produce desirable compounds. However, this usually requires to manipulate these organisms by genetic engineering and/ or changing the enviromental conditions to make the production of these compounds possible. In many cases, it is necessary to enrich the genetic material of those microbes with hereologous pathways from other species and consequently adding the potential to produce novel compounds. This paper introduces a new plug-in for the OptFlux Metabolic Engineering platform, aimed at finding suitable sets of reactions to add to the genomes of selected microbes (wild type strain), as well as finding complementary sets of deletions, so that the mutant becomes able to overproduce compounds with industrial interest, while preserving their viability. The necessity of adding reactions to the metabolic model arises from existing gaps in the original model or motivated by the productions of new compounds by the organism. The optimization methods used are metaheuristics such as Evolutionary Algorithms and Simulated Annealing. The usefulness of this plug-in is demonstrated by a case study, regarding the production of vanillin by the bacterium E. coli.
Personality Disorders After Age 50: A Meta-Analysis

A meta-analytic approach was used to review the literature for trends concerning the frequency and distribution of personality disorder symptomatology in older adults, and to consider implications for future investigation. Eleven articles published from 1980 through 1994 met the study criteria: (1) Personality disorder diagnoses based upon DSM-III or DSM-III-R criteria; (2) original data reported in the study; (3) sufficient information reported so that meta-analytic procedures could be followed; (4) a focus upon older adults (age 50 and above) by the study or a clearly measurable older group within the study; and (5) assessment of personality disorders that included the full spectrum of disorders. Overall, the prevalence of personality disorders in this age group was 10%. The frequency of personality disorders in the individual studies included in the analysis ranged from 6% in a sample of geriatric patients treated for depression to 33% in a separate sample of recovered elderly depressives. Emerging mos.
Downlink power allocation for multi-class wireless systems

In this paper we consider a power allocation problem in multi-class wireless systems. We focus on the downlink of the system. Each mobile has a utility function that characterizes its degree of satisfaction for the received service. The objective is to obtain a power allocation that maximizes the total system utility. Typically, natural utility functions for each mobile are nonconcave. Hence, we cannot use existing convex optimization techniques to derive a global optimal solution. We develop a simple (distributed) algorithm to obtain a power allocation that is asymptotically optimal in the number of mobiles. The algorithm is based on dynamic pricing and consists of two stages. At the mobile selection stage, the base station selects mobiles to which power is allocated. At the power allocation stage, the base station allocates power to the selected mobiles. We provide numerical results that illustrate the performance of our scheme. In particular, we show that our algorithm results in system performance that is close to the performance of a global optimal solution in most cases.
A Coactivation Strategy in Anticipatory Postural Adjustments in Persons with Down Syndrome

The hypothesis that persons with Down syndrome are likely to trade mechanical efficacy of motor patterns for safety was tested in a study of postural adjustments associated with fast voluntary movements. Control subjects and subjects with Down syndrome performed bilateral shoulder flexion and extension movements “as fast as possible” while standing on a force platform. Anticipatory changes in the background activity of postural muscles were seen in both groups of subjects. Subjects with Down syndrome demonstrated simultaneous EMG bursts in postural “agonist-antagonist” pairs. Subjects with Down syndrome also demonstrated patterns of deviations in the major postural joints, suggesting that they were using a different strategy which may be a correlate of “clumsiness. ” It was concluded that practice in conditions of changing components of a motor task is the most promising way to encourage the central nervous system of persons with Down syndrome to search for alternative strategies and improve these individu.
Critical elements in defining work-based identity in a post-apartheid South Africa

Orientation: The main focus of the study was to answer the question: ‘Who am I at work? ’ in a post-apartheid South African organisation. Research purpose: The aim of the specific research questions was to determine which life sphere and life role elements, and which work-based identity facets were significant in forming work-based identity. Motivation for the study: The findings of the study will enable the formulation of an integrative definition of work-based identity applicable to the South African context. Research design, approach and method: Qualitative data was collected by means of unstructured interviews with 29 employees representing a range of job titles, levels and demographics in a large South African manufacturing company. A grounded theory approach (open and axial coding) was used to analyse the data. Main findings: Distinctive individual self-definitions and a number of common themes integrating social and personal identity perspectives emerged from the data. These themes provided a sound basis for the proposed integrative model to define work-based identity. Practical/managerial implications: The findings of this research will assist human resource practitioners to develop training interventions and management strategies for the potential enhancement of work-based identities. This will result in a more engaged and harmonised workforce. Contribution/value-add: This was the first study of its kind to identify and delineate significant work-based identity elements for the formation of a work-based identity within a South African work context.
A Meta-Analysis of Aortic Root Size in Elite Athletes

Background— The aorta is exposed to hemodynamic stress during exercise, but whether or not the aorta is larger in athletes is not clear. We performed a systematic literature review and meta-analysis to examine whethere athletes demonstrate increased aortic root dimensions compared with nonathlete controls. Methods and Results— We searched MEDLINE and Scopus from inception through August 12, 2012, for English-language studies reporting the aortic root size in elite athletes. Two investigators independently extracted athlete and study characteristics. A multivariate linear mixed model was used to conduct meta-regression analyses. We identified 71 studies reporting aortic root dimensions in 8564 unique athletes, but only 23 of these studies met our criteria by reporting aortic root dimensions at the aortic valve annulus or sinus of Valsalva in elite athletes (n=5580). Athletes were compared directly with controls (n=727) in 13 studies. On meta-regression, the weighted mean aortic root diameter measured at the sinuses of Valsalva was 3.2 mm (P=0.02) larger in athletes than in the nonathletic controls, whereas aortic root size at the aortic valve annulus was 1.6 mm (P=0.04) greater in athletes than in controls. Conclusions— Elite athletes have a small but significantly larger aortic root diameter at the sinuses of Valsalva and aortic valve annulus, but this difference is minor and clinically insignificant. Clinicians evaluating athletes should know that marked aortic root dilatation likely represents a pathological process and not a physiological adaptation to exercise.
The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses

CD5L (CD5 molecule-like) is a secreted glycoprotein that participates in host response to bacterial infection. CD5L influences the monocyte inflammatory response to the bacterial surface molecules lipopolysaccharide (LPS) and lipoteichoic acid (LTA) by inhibiting TNF secretion. Here we studied the intracellular events that lead to macrophage TNF inhibition by human CD5L. To accomplish this goal, we performed functional analyses with human monocytic THP1 macrophages, as well as with peripheral blood monocytes. Inhibition of phosphatidylinositol 3-kinase (PtdIns3K) reversed the inhibitory effect of CD5L on TNF secretion. Among the various PtdIns3K isoforms, our results indicated that CD5L activates PtdIns3K (whose catalytic subunit is termed PIK3C3), a key modulator involved in autophagy. Further analysis revealed a concomitant enhancement of autophagy markers such as cellular LC3-II content, increased LC3 puncta, as well as LC3-LysoTracker Red colocalization. Moreover, electron microscopy showed an increased presence of cytosolic autophagosomes in THP1 macrophages overexpressing CD5L. Besides preventing TNF secretion, CD5L also inhibited IL1B and enhanced IL10 secretion. This macrophage anti-inflammatory pattern of CD5L was reverted upon silencing of autophagy protein ATG7 by siRNA transfection. Additional siRNA experiments in THP1 macrophages indicated that the induction of autophagy mechanisms by CD5L was achieved through cell-surface scavenger receptor CD36, a multiligand receptor expressed in a wide variety of cell types. Our data represent the first evidence that CD36 is involved in autophagy and point to a significant contribution of the CD5L-CD36 axis to the induction of macrophage autophagy.
The Role of the Lateral Habenula in Punishment

The lateral habenula (LHb) is a small epithalamic structure that projects via the fasciculus retroflexus to the midbrain. The LHb is known to modulate midbrain dopamine (DA) neurons, including inhibition of ventral tegmental area (VTA) neurons via glutamatergic excitation of the GABAergic rostromedial tegmental nucleus (RMTg). A variety of lines of evidence show activity in LHb and the LHb-RMTg pathway is correlated with, and is sufficient to support, punishment learning. However, it is not immediately clear whether LHb is necessary for punishment. Here we used a within-subjects punishment task to assess the role of LHb in the acquisition and expression of punishment as well as in aversive choice. Rats that pressed two individually presented levers for pellet rewards rapidly suppressed responding to one lever if it also caused footshock deliveries (punished lever) but continued pressing a second lever that did not cause footshock (unpunished lever). Infusions of an AMPA receptor antagonist (NBQX) into LHb had no effect on the acquisition or expression of this punishment, or on aversive choice, but did increase locomotion. Infusion of the sodium channel blocker bupivacaine likewise had no effect on expression of punishment. However, infusion of the calcium channel blocker mibefradil did affect expression of punishment by significantly decreasing the latency with which rats responded on the punished lever and significantly increasing unpunished lever-pressing. Taken together, these findings indicate that the LHb plays a limited role in punishment, influencing only latency to respond. This role is linked to calcium channel permeability and not AMPA receptor or sodium channel permeability.
Authenticated Byzantine Fault Tolerance Without Public-Key Cryptography

We have developed a practical state-machine replication algorithm that tolerates Byzantine faults: it works correctly in asynchronous systems like the Internet and it incorporates several optimizations that improve the response time of previous algorithms by more than an order of magnitude. This paper describes the most important of these optimizations. It explains how to modify the base algorithm to eliminate the major performance bottleneck in previous systems — public-key cryptography. The optimization replaces public-key signatures by vectors of message authentication codes during normal operation, and it overcomes a fundamental limitation on the power of message authentication codes relative to digital signatures — the inability to prove that a message is authentic to a third party. As a result, authentication is more than two orders of magnitude faster while providing the same level of security.
The relevance of models for social anthropology

There has been much discussion in recent years about the construction of theoretical models useful in the explanation of particular areas of social organization. This volume charts that discussion and its results and covers a wide ethnographic range from the Pacific Island of Truk through African pastoral societies, south-east Asia and Hong Kong, back to Polynesia. First published in 1965.
PAX2 maintains the differentiation of mouse oviductal epithelium and inhibits the transition to a stem cell-like state

Recent studies have provided evidence that the secretory cells of the fallopian tube (oviduct) are a probable origin for high-grade serous ovarian carcinoma. In addition to secretory cells, the fallopian tube epithelium consists of ciliated cells and CD44+ undifferentiated stem-like cells. Loss of PAX2 expression is recognized as an early event in epithelial transformation, but the specific role of PAX2 in this transition is unknown. The aim of this study was to define the role of PAX2 in oviductal epithelial (OVE) cells and its response to transforming growth factor β1 (TGFβ), characterizing specifically its potential involvement in regulating stem cell-like behaviors that may contribute to formation of cancer-initiating cells. Treatment of primary cultures of mouse OVE cells with TGFβ induced an epithelial-mesenchymal transition (EMT) associated with decreased expression of PAX2 and an increase in the fraction of cells expressing CD44. PAX2 knockdown in OVE cells and overexpression in ovarian epithelial cells confirmed that PAX2 inhibits stem cell characteristics and regulates the degree of epithelial differentiation of OVE cells. These results suggest that loss of PAX2, as occurs in serous tubal intraepithelial carcinomas, may shift secretory cells to a more mesenchymal phenotype associated with stem-like features.