Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of Cyclin-Dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance after Global Ischemia in the Rat

Increasing evidence suggests that cyclin-dependent kinases participate in neuronal death induced by multiple stresses in vitro. However, their role in cell death paradigms in vivo is not well characterized. Accordingly, the authors examined whether cyclin-dependent kinase inhibition resulted in functionally relevant and sustained neuroprotection in a model of global ischemia. Intracerebroventricular administration of the cyclin-dependent kinase inhibitor flavopiridol, immediately or at 4 hours postreperfusion after a global insult, reduced injury in the CA1 of the hippocampus when examined 7 days after reperfusion. No significant protection was observed when flavopiridol was administered 8 hours after reperfusion. The tumor-suppressor retinoblastoma protein, a substrate of cyclin-dependent kinase, was phosphorylated on a cyclin-dependent kinase consensus site after the global insult; this phosphorylation was inhibited by flavopiridol administration. Importantly, flavopiridol had no effect on core body temperature, suggesting that the mechanism of neuroprotection was through cyclin-dependent kinase inhibition but not through hypothermia. Furthermore, inhibition of cyclin-dependent kinases improved spatial learning behavior as assessed by the Morris water maze 7 to 9 days after reperfusion. However, the histologic protection observed at day 7 was absent 28 days after reperfusion. These results indicate that cyclin-dependent kinase inhibition provides an extended period of morphologic and functional neuroprotection that may allow time for other neuroprotective modalities to be introduced.
Risk factors for shock in children with dengue fever

Objectives: To evaluate and analyze the clinical and laboratory parameters that were predictive of the development of shock in children with dengue fever. Subjects and Methods: Retrospective study carried out from August 2012 to July 2014 at a tertiary care hospital in Puducherry. Results: Two hundred and fifty-four children were admitted with dengue fever and among them dengue fever without shock was present in 159 children (62.5%) and dengue fever with shock was present in 95 cases (37.4%). Various clinical and laboratory parameters were analyzed using univariate and multivariate logistic regression between the two groups and a P value of <0.05 was taken as significant. The most common risk factors for shock on univariate analysis were headache, retro-orbital pain, palmar erythema, joint pain, facial flush, splenomegaly, lymphadenopathy, bleeding, giddiness, persistent vomiting, pleural effusion, ascites, hematocrit >20% with concomitant platelet count <50,000/mm3 on admission, deranged liver function tests, and gallbladder wall edema. On multivariate analysis, it was seen that in age >6 years, hepatomegaly, pain in the abdomen, and oliguria were the most common risk factors associated with shock in children with dengue fever. There were six deaths (2.4%) and out of them four presented with impaired consciousness (66.6%) at the time of admission. Conclusion: Age >6 years, hepatomegaly, abdomen pain, and oliguria were the most common risk factors for shock in children with dengue fever. Impaired consciousness at admission was the most ominous sign for mortality in dengue fever. Hence, these features should be identified early, monitored closely, and managed timely.
Nutrition support among critically ill children with AKI.

BACKGROUND Critically ill children are at high risk of underfeeding and AKI, which may lead to further nutritional deficiencies. This study aimed to determine the adequacy of nutrition support during the first 5 days of intensive care unit (ICU) stay. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A chart review of pediatric patients admitted to the pediatric ICU for >72 hours between August 2007 and March 2008 was conducted. Patients were classified as having no AKI versus AKI by modified pediatric RIFLE criteria. All nutrition was analyzed. Basal metabolic rate (BMR) was estimated by the Schofield equation and protein needs by American Society for Parenteral and Enteral Nutrition guidelines. RESULTS Of the 167 patients, 102 were male and 65 were female (median age 1.4 years). Using the RIFLE criteria, 102 (61%) patients had no AKI, whereas 44 (26%) were classified as category R (risk), 12 (7%) as category I (injury), and 9 (5%) as category F (failure). The median 5-day energy intake was lower relative to estimated BMR. Overall protein provision (19%) was lower than energy provision (55%) compared with estimated needs (P<0.001). I/F patients were more likely to be fasted versus receiving enteral/parenteral nutrition (n=813 patient days) and to receive <90% of BMR (n=832 patient days) than No AKI/R patients. CONCLUSIONS Underfeeding, common in critically ill children, was accentuated in AKI. Protein underfeeding was greater than energy underfeeding in the first 5 days of PICU stay. Efforts should be made to provide adequate nutrition in ICU patients with AKI.
Live-attenuated Tetravalent Dengue Vaccine in Dengue-naïve Children, Adolescents, and Adults in Mexico City: Randomized Controlled Phase 1 Trial of Safety and Immunogenicity

Background: Preliminary results in healthy, young US adults showed that a tetravalent, live-attenuated dengue vaccine (TDV) was safe and immunogenic, but no data are available in children. Methods: In a multicenter, randomized, controlled, observer-blinded study in the city of Mexico, children aged 2 to 5, 6 to 11, and 12 to 17 years (36 children per age group), and adults (n = 18) aged <45 years received the following: 3 injections of TDV at months 0, 3.5, and 12 (TDV-TDV-TDV), or 1 injection of yellow fever vaccine (YF) at month 0, and 2 injections of TDV at months 3.5 and 12 (YF-TDV-TDV). Adverse events and biologic safety (biochemistry and hematology) were documented. Plaque reduction neutralization test (PRNT50) antibody titers against the TDV parental viruses were measured 28 days after vaccination. Seropositivity was defined as antibody titers ≥10 1/dil. Results: No vaccine-related serious adverse events, other significant clinical adverse events, or clinically significant trends in biologic safety were observed. Reactogenicity did not increase with successive TDV injections, and mild-to-moderate injection site pain, headache, myalgia, and malaise were most commonly reported (14%–40% after each vaccination). After 3 TDV vaccinations, the seropositivity rate against each dengue serotype was in the range 77% to 92%, compared with 85% to 94% after completion of the YF-TDV-TDV regimen. Of the 2- to 11-year-old participants, 95% were seropositive against ≥3 serotypes after 3 vaccinations. Conclusions: A 3-dose TDV regimen had a favorable safety profile in children and adults and elicited neutralizing antibody responses against all 4 serotypes. These findings support the continued development of this vaccine.
Discrete Partitioning and Coverage Control for Gossiping Robots

We propose distributed algorithms to automatically deploy a team of mobile robots to partition and provide coverage of a nonconvex environment. To handle arbitrary nonconvex environments, we represent them as graphs. Our partitioning and coverage algorithm requires only short-range, unreliable pairwise “gossip” communication. The algorithm has two components: 1) a motion protocol to ensure that neighboring robots communicate at least sporadically and 2) a pairwise partitioning rule to update territory ownership when two robots communicate. By studying an appropriate dynamical system on the space of partitions of the graph vertices, we prove that territory ownership converges to a pairwise-optimal partition in finite time. This new equilibrium set represents improved performance over common Lloyd-type algorithms. Additionally, our algorithm is an "anytime algorithm'' that also scales well for large teams and can be run by on-board computers with limited resources. Finally, we report on large-scale simulations in complex environments and hardware experiments using the Player/Stage robot control system.
Finite element analysis of fretting wear considering variable coefficient of friction

Fretting wear is a kind of material damage in contact surfaces caused by microrelative displacement between two bodies. It can change the profile of contact surfaces, resulting in loosening of fasteners or fatigue cracks. Finite element method is an effective method to simulate the evolution of fretting wear process. In most studies of fretting wear, the coefficient of friction was assumed to be constant to simplify model and reduce the difficulty of solving. However, fretting wear test showed that the coefficient of friction was a variable related to the number of fretting cycles. Therefore, this paper introduces the coefficient of friction as a function of the number of fretting cycles in numerical simulation. A wear model considering variable coefficient of friction is established by combining energy consumption model and adaptive grid technique. The nodes of contact surfaces are updated through the UMESHMOTION subroutine. The effects of constant coefficient of friction and variable coefficient of friction on fretting wear are analyzed by comparing the wear amount under different loading conditions. The results show that when compared with coefficient of friction model, fretting wear is obviously affected by variable coefficient of friction and the variable coefficient of friction model has a larger wear volume when the fretting is in partial slip condition and mixed slip condition. In gross slip condition, the difference of wear volume between variable coefficient of friction model and coefficient of friction model decreases with the increase in the displacement amplitudes.
Improving interfacial adhesion between copper foil and resin using amino acid in printed circuit board industry

Abstract The corrosion inhibitor of nitrogen-containing amino acid histidine (His) has been applied in brown oxidation solutions and the relationships between brown oxidation solutions with the various concentrations of His and the adhesion strength of copper/resin laminates have been systematically studied by various testing techniques, including electrochemical impedance spectroscopy (EIS), peeling strength and field emission scanning electronic microscope. The result obtained from EIS suggested that His exhibited excellent anti-corrosive performance which contributed to a higher stability of the organic metallic film post brown oxidation process treatment. The roughness surface like honeycomb structure was gained and peel strength of the Cu/resin laminates was raised up to 0.71 kg/cm by altering the concentration of His in brown oxidation solutions. Moreover, theoretical calculations manifested that the studied inhibitor was almost adsorbed in parallel on the copper surface and X-ray photoelectron spectroscopy (XPS) declared that the value of adhesion strength was related to the surface chemistry of copper foil and resins after the lamination process which may attribute to chemical reactions at the copper/resin interface.
A Simple Optimization Model for Wireless Opportunistic Routing with Intra-Session Network Coding

In this paper, we consider the optimization of multi-path opportunistic routing and congestion control in wireless mesh networks with intra-session network coding. We model this as a network utility maximization problem and we design a simple distributed solution that can be obtained by solving the dual problem. This formulation provides useful insight into the complex cross-layer interaction between intra-session network coding, multi-path routing and transport layer and a mathematical foundation for protocol design in this scenario.
Putting evidence into practice: evidence-based interventions for sleep-wake disturbances.

Symptom management is a vital aspect of the practice of oncology nursing. The Oncology Nursing Society has identified outcomes sensitive to nursing intervention, known as nursing-sensitive patient outcomes. This article presents information about sleep-wake disturbances that occur in patients with cancer and makes recommendations for evidence-based interventions to improve sleep for patients. Sleep-wake disturbances occur in 30%-75% of people with cancer and have a negative impact on other symptoms and quality of life. Despite the frequency and severity of sleep-wake disturbances, limited research has tested interventions to improve sleep-wake outcomes. Although no interventions currently receive the highest recommendations for implementation into practice, several nonpharmacologic interventions show initial positive findings in promoting high-quality sleep and daytime functioning. Oncology nurses can screen for sleep-wake disturbances and suggest tailored interventions. Four categories of promising interventions are cognitive-behavioral therapy, complementary therapies, psychoeducation and information, and exercise. Clinicians can use the Putting Evidence Into Practice (PEP) card and PEP resources at www.ons. org/outcomes to improve sleep-wake outcomes.
Oxidative stress in androgenetic alopecia

Rationale:Androgenetic alopecia is not considered a life threatening disease but can have serious impacts on the patient’s psychosocial life. Genetic, hormonal, and environmental factors are considered responsible for the presence of androgenetic alopecia. Recent literature reports have proved the presence of inflammation and also of oxidative stress at the level of dermal papilla cells of patients with androgenetic alopecia Objective:We have considered of interest to measure the oxidative stress parameters in the blood of patients with androgenetic alopecia Methods and results:27 patients with androgenetic alopecia and 25 age-matched controls were enrolled in the study. Trolox Equivalent Antioxidant Capacity (TEAC), malondialdehyde (MDA) and total thiols levels were measured on plasma samples. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activities, and also non protein thiols levels together with TEAC activity were determined on erythrocytes samples No statistically significant changes were observed for TEAC erythrocytes, non-protein thiols, GPx and CAT activities. Significantly decreased (p<0.01) SOD activity was found in patients with androgenetic alopecia. For plasma samples decreased TEAC activity (p<0.001), increased MDA levels (p<0.001) and no change in total thiols concentration were found in patients when compared with the controls. Discussions:Decreased total antioxidant activity and increased MDA levels found in plasma samples of patients with androgenetic alopecia are indicators of oxidative stress presence in these patients. Significantly decreased SOD activity but no change in catalase, glutathione peroxidase, non protein thiols level and total antioxidant activity in erythrocytes are elements which suggest the presence of a compensatory mechanism for SOD dysfunction in red blood cells of patients with androgenetic alopecia. Abbreviations: AAG = androgenetic alopecia, MDA = malondialdehyde, SOD = superoxide dismutase, CAT = catalase, GPx = glutathione peroxidase, GSH = glutathione, GST = glutathione transferase, SH = thiols, TEAC = trolox equivalent antioxidant capacity, ABTS = 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid), CDNB = 1-chloro-2,4-dinitrobenzene
SELECTION FOR AMYLASE ALLOZYMES IN DROSOPHILA MELANOGASTER

The biological significance of allozyme variation within natural populations has been a major source of controversy in population genetics since the first quantitative estimates of such variation were made (Lewontin and Hubby, 1966). A variety of theoretical and experimental strategies have been used in an effort to discriminate between 'neutralist' and 'selectionist' explanations of the maintenance of this variation. Experimental approaches to the problem have been hampered by the fact that little is known about the physiological role of many of these enzyme proteins. In particular, it has been difficult to isolate an environmental challenge that could be deemed, with some certainty, to be relevant to the gene locus in question. The experiment described here illustrates a situation that is particularly favorable to the demonstration of the action of selective processes at a specific enzyme locus. Two strains of Drosophila melanogaster, derived from separate natural populations, were used, each isogenic for a different amylase allele. The alleles in question were Amy 1-c and Amy 4,6, as classified by Doane (1970). Amy 4,6 has a higher enzymatic activity as measured by the production of maltose from starch, using whole-fly homogenates (Doane, 1970). This result was confirmed in our laboratory using the relative intensities of bands on polyacrylamide gels stained by the starchiodine method. Six third instar larvae were homogenized in 60 Il borate buffer (pH 8.9). Two replicate samples of 15 1l from
The impact of abiotic and biogenic mn oxide coatings on contaminant mobility, bioavailability, and attenuation

THE IMPACT OF ABIOTIC AND BIOGENIC MN OXIDE COATINGS ON CONTAMINANT MOBILITY, BIOAVAILABILITY, AND ATTENUATION by Thipnakarin Boonfueng Abiotic and biogenic manganese oxide coatings significantly impact the mobility and bioavailability of metals in soils and sediments. While sorption to discrete Mn oxides has been investigated in a number of studies, coatings have not received as much attention. Abiotic nanocrystalline (hydrous manganese oxide (HMO)) and crystalline Mn oxides (birnessite and pyrolusite) coated on montmorillonite were studied for formation, structure, stability, and surface properties. Coatings dominated the clay surface characteristics where the surface charge behaved similar to that of the discrete oxide and the local structure was consistent with the pure oxide phase. Furthermore, in sorption studies, Zn and Pb ions formed inner-sphere complexes as tridentate and bidentate corner-sharing structures, respectively. On the other hand, vacancy sites along the oxide surface were occupied by Ni. In biomineralization, a nano-particulate Mn oxide coated the sheathed Leptothrix discophora SP-6 forming a dendritic biofilm structure. The surface charge and the local structure were consistent with that of abiotic HMO where the oxide potentially forms a polymer-like precursor to birnessite consistent with the phyllomanganate family. Surface properties of the coated bacteria are dominated by the oxide as Zn formed inner-sphere complexes resulting in octahedral structures. On the other hand, sorption to the sheathed L. discophora SP-6 involved complexation with phosphoryl (84%) and carboxyl (16%) groups. The slow sorption process, intraparticle surface diffusion, was observed in abiotic and biogenic oxide systems, indicating that Mn oxide present as coatings or discrete particles acts as a sink for metal contaminants. THE IMPACT OF ABIOTIC AND BIOGENIC MN OXIDE COATINGS ON CONTAMINANT MOBILITY, BIOAVAILABILITY, AND ATTENUATION by Thipnakarin Boonfueng A Dissertation Submitted to the Faculty of New Jersey Institute of Technology In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in Environmental Engineering Department of Civil and Environmental Engineering
Diversity, Serendipity, Novelty, and Coverage

What makes a good recommendation or good list of recommendations? Research into recommender systems has traditionally focused on accuracy, in particular how closely the recommender’s predicted ratings are to the users’ true ratings. However, it has been recognized that other recommendation qualities—such as whether the list of recommendations is diverse and whether it contains novel items—may have a significant impact on the overall quality of a recommender system. Consequently, in recent years, the focus of recommender systems research has shifted to include a wider range of “beyond accuracy” objectives. In this article, we present a survey of the most discussed beyond-accuracy objectives in recommender systems research: diversity, serendipity, novelty, and coverage. We review the definitions of these objectives and corresponding metrics found in the literature. We also review works that propose optimization strategies for these beyond-accuracy objectives. Since the majority of works focus on one specific objective, we find that it is not clear how the different objectives relate to each other. Hence, we conduct a set of offline experiments aimed at comparing the performance of different optimization approaches with a view to seeing how they affect objectives other than the ones they are optimizing. We use a set of state-of-the-art recommendation algorithms optimized for recall along with a number of reranking strategies for optimizing the diversity, novelty, and serendipity of the generated recommendations. For each reranking strategy, we measure the effects on the other beyond-accuracy objectives and demonstrate important insights into the correlations between the discussed objectives. For instance, we find that rating-based diversity is positively correlated with novelty, and we demonstrate the positive influence of novelty on recommendation coverage.
Impacts of four communication programs on HIV testing behavior in South Africa

This paper aims to evaluate the impacts of four communication programs on promoting HIV testing behavior among sexually active individuals in South Africa. The four programs, implemented by Johns Hopkins Health and Education in South Africa, are aimed to promote HIV prevention behaviors, as well as gender-based violence prevention, tuberculosis screening and treatment, and reduction of alcohol consumption. Launched between 2009 and 2010, they all promoted HIV testing. Data came from the population-based Third National AIDS Communication Survey 2012; 6004 men and women who had sex within the last 12 months were included in the analysis. Multiple causal attribution analysis is used to justify causal reference and estimate the impact of communication programs. Findings indicate significant direct and indirect effects of the programs on HIV testing behavior. Indirect effects worked through increasing one's likelihood of perceiving that their friends were tested and the probability of talking about HIV testing with sex partners and friends, which in turn increased the likelihood of HIV testing. Findings suggest multiple angles from which communication programs can promote HIV testing. The study also demonstrates the use of multiple statistical techniques for causal attribution in a post-only design, where randomization is not possible.