Miracle-dz/UniFAR-FTUs huggingface dataset:
Vascular Health and Risk Management Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article Dovepress Comparison of Prasugrel and Clopidogrel in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Antiplatelet agents are the cornerstone of treatment for patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Clopidogrel, when added to aspirin, has demonstrated considerable success at reducing thrombotic complications of ACS and/or PCI compared to aspirin alone and is standard of care for the management of patients with ACS and in patients undergoing PCI. Prasugrel is a novel thienopyridine antiplatelet agent recently approved for the treatment of patients with ACS undergoing PCI. Prasugrel provides greater and more consistent platelet inhibition than clopidogrel due to earlier and more extensive formation of its active metabolite. The enhanced platelet inhibition with prasugrel led to a reduction in major adverse cardiovascular events in patients with moderate to high risk ACS scheduled for PCI in the phase 3 TRITON-TIMI 38 trial. This benefit was seen more in patients suffering a STEMI and those with diabetes. However, this reduction in events was met with a significant increase in the risk of bleeding which overcame prasugrel's benefit in certain groups. Future studies with prasugrel are needed to determine its optimal utilization to minimize bleeding risks and evaluate its outcomes in ACS and safety profile in special patient populations.
An overview of anonymous communications in mobile ad hoc networks

Security is an important topic in the context of mobile ad hoc networks (MANETs). The particular features of these networks, such as the use of open air as the transmission medium or computational constraints, make them vulnerable. One of the mechanisms to protect the communication is to provide anonymity, that aims at hiding the participants' identities, as well as the message contents and any kind of information about the transaction. For this purpose, some additional security mechanisms are required, usually based on cryptographic techniques. In this paper, we review the most relevant anonymity studies in the literature, starting with an analysis of proposals for wired networks, and then moving on to MANET environments. We also present a taxonomy to differentiate proposals according to the degree of anonymity offered. Copyright © 2010 John Wiley & Sons, Ltd. (The paper reviews the most relevant anonymity studies, starting with an analysis of the proposals for wired networks, and then moving on to MANET environments. Such proposals are presented according to the degree of anonymity offered, from the least to the most anonymous proposals.)
Molecular epidemiology investigations in 8 Romanian outbreaks of rabbit Pasteurellosis by pulsed-field gel electrophoresis

Pasteurellosis is one of the most serious diseases of rabbits, with considerable economic loss in large production units and unfavourable prognosis for rabbits with clinical signs. The rabbits can develop health problems caused by Pasteurella, especially if they are unwell or stressed, and clinical pattern and lesions can be heterogeneous. The identification and quantification of risk factors are difficult and dependent by subjectivity of pet owner. This study is focused on pet rabbits that were diagnosed with pasteurellosis. The major stress factors identified in our study were: phonic stress, excessive manipulation, transport stress and improper feeding. Clinical and lesion data collected in this study support the heterogeneity of rabbit Pasteurella infections, previously described in several papers. The etiological study was split in following stage of diagnostics: classical bacteriological investigations and comparison of the profiles of pulsed-field gel electrophoresis bands. The study revealed that P. multocida strains isolated on pet rabbits have a high variability.
Absolute and Relative Training Load and Its Relation to Fatigue in Football

The aim of the study was to assess the relationship of external and internal training load (TL) indicators with the objective and subjective fatigue experienced by 15 semi-professional football players, over eight complete weeks of the competition period in the 2015–2016 season, which covered microcycles from 34th to 41st. The maximum heart rate (HRmax) and maximum speed (Vmax) of all the players were previously measured in specific tests. The TL was monitored via questionnaires on rating of perceived exertion (RPE), pulsometers and GPS devices, registering the variables: total distance (TD), player load 2D (PL2D), TD at >80% of the Vmax (TD80), TD in deceleration at < -2 m⋅sec-2 (TDD <-2), TD in acceleration >2 m⋅sec-2 (TDA >2), Edwards (ED), time spent at between 50 and 80% (50–80% HRmax), 80–90% (80–90% HRmax), and >90% of the HRmax (>90% HRmax), and RPE both respiratory/thoracic (RPEres) and leg/muscular (RPEmus). All the variables were analyzed taking into account both the absolute values accumulated over the week and the normalized values in relation to individual mean competition values. Neuromuscular fatigue was measured objectively using the countermovement jump test and subjectively via the Total Quality Recovery (TQR) scale questionnaire. Analytical correlation techniques were later applied within the general linear model. There is a correlation between the fatigue experienced by the player, assessed objectively and subjectively, and the load accumulated over the week, this being assessed in absolute and relative terms. Specifically, the load relative to competition correlated with the physical variables TD (-0.279), PL2D (-0.272), TDD < -2 (-0.294), TDA >2 (-0.309), and sRPEmus (-0.287). The variables related to heart rate produced a higher correlation with TQR. There is a correlation between objectively and subjectively assessed fatigue and the accumulated TL of a player over the week, with a higher sensitivity being shown when compared to the values related to the demands of competition. Monitoring load and assessing fatigue, we are closer to knowing what the prescription of an adequate dose of training should be in order for a player to be as fresh as possible and in top condition for a match. Normalizing training demands with respect to competition could be an appropriate strategy for individualizing player TL.
A multi-level solution algorithm for steady-state Markov chains

A new iterative algorithm, the multi-level algorithm, for the numerical solution of steady state Markov chains is presented. The method utilizes a set of recursively coarsened representations of the original system to achieve accelerated convergence. It is motivated by multigrid methods, which are widely used for fast solution of partial differential equations. Initial results of numerical experiments are reported, showing significant reductions in computation time, often an order of magnitude or more, relative to the Gauss-Seidel and optimal SOR algorithms for a variety of test problems. It is shown how the well-known iterative aggregation-disaggregation algorithm of Takahashi can be interpreted as a special case of the new method.
Antibacterial treatment of bacterial vaginosis: current and emerging therapies

Bacterial vaginosis is a common cause of malodorous vaginal discharge. It is also associated with sexually transmitted infections and adverse pregnancy outcomes. The magnitude of the gynecological and obstetrical consequences has stimulated therapeutic research and led to the testing of several therapies. The objective of this work is to present the currently available therapeutic strategies for the treatment of bacterial vaginosis and associated recommendations, and discuss the emerging therapies.
Postoperative infusional continuous regional analgesia. A technique for relief of postoperative pain following major extremity surgery.

A new technique using postoperative infusional continuous regional analgesia (PICRA) for postoperative pain relief was investigated in 23 surgical patients treated by amputation (12 patients) or by limb-salvage resection operations (11 patients). Bupivacaine was delivered into peripheral nerve sheaths via catheters placed therein at the time of surgery. Only patients in whom the nerves were easily accessible were treated. Catheters were placed in the axillary sheath, the lumbosacral trunk, and the femoral nerve sheaths of patients treated with shoulder girdle and pelvic procedures (resections and amputations), and within the sciatic nerve sheath of those treated with lower extremity procedures. The anesthetic agent was delivered at controllable rates. Regional analgesia was obtained in the operative site with minimal motor or sensory decrease. To assess the efficacy of this technique, the results of this study group were compared with those of a matched group of 11 patients treated with similar surgical procedures but who received epidural morphine. Eleven of the 23 patients on PICRA required no supplemental narcotic agents. The mean level of the narcotic agents required by the remaining 13 PICRA patients was approximately one third of that required by the matched group of 11 patients receiving epidural morphine. Overall, the patients on PICRA had an 80% reduction of narcotic requirements when compared to the historical controls. The technique is reliable and can be performed by the surgeon, requiring about a ten-minute increase in operating time. It has potentially wide application in orthopedics in procedures in which the major nerves are easily accessible (e.g., pelvic fractures and revision hip surgery) and for patients with intractable pain of the extremities.
NMR Spectroscopy of Paramagnetic Metalloproteins

This article deals with the solution structure determination of paramagnetic metalloproteins by NMR spectroscopy. These proteins were believed not to be suitable for NMR investigations for structure determination until a decade ago, but eventually novel experiments and software protocols were developed, with the aim of making the approach suitable for the goal and as user‐friendly and safe as possible. In the article, we also give hints for the optimization of experiments with respect to each particular metal ion, with the aim of also providing a handy tool for nonspecialists. Finally, a section is dedicated to the significant progress made on 13C direct detection, which reduces the negative effects of paramagnetism and may constitute a new chapter in the whole field of NMR spectroscopy.
Impacts on the Deep-Sea Ecosystem by a Severe Coastal Storm

Major coastal storms, associated with strong winds, high waves and intensified currents, and occasionally with heavy rains and flash floods, are mostly known because of the serious damage they can cause along the shoreline and the threats they pose to navigation. However, there is a profound lack of knowledge on the deep-sea impacts of severe coastal storms. Concurrent measurements of key parameters along the coast and in the deep-sea are extremely rare. Here we present a unique data set showing how one of the most extreme coastal storms of the last decades lashing the Western Mediterranean Sea rapidly impacted the deep-sea ecosystem. The storm peaked the 26th of December 2008 leading to the remobilization of a shallow-water reservoir of marine organic carbon associated with fine particles and resulting in its redistribution across the deep basin. The storm also initiated the movement of large amounts of coarse shelf sediment, which abraded and buried benthic communities. Our findings demonstrate, first, that severe coastal storms are highly efficient in transporting organic carbon from shallow water to deep water, thus contributing to its sequestration and, second, that natural, intermittent atmospheric drivers sensitive to global climate change have the potential to tremendously impact the largest and least known ecosystem on Earth, the deep-sea ecosystem.
Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity

Cytokines are key regulatory mediators involved in the host response to immunological challenges, but also play a critical role in the communication between the immune and the central nervous system. For this, their expression in both systems is under a tight regulatory control. However, pathological conditions may lead to an overproduction of pro-inflammatory cytokines that may have a detrimental impact on central nervous system. In particular, they may damage neuronal structure and function leading to deficits of neuroplasticity, the ability of nervous system to perceive, respond and adapt to external or internal stimuli. In search of the mechanisms by which pro-inflammatory cytokines may affect this crucial brain capability, we will discuss one of the most interesting hypotheses: the involvement of the neurotrophin brain-derived neurotrophic factor (BDNF), which represents one of the major mediators of neuroplasticity.
Visual and refractive outcome of one-site phacotrabeculectomy compared with temporal approach phacoemulsification

Background We aimed to compare visual and refractive outcome following phacoemulsification and intraocular lens implant (IOL) and combined one-site phacotrabeculectomy. Method We performed a retrospective study of case records of patients who had temporal incision phacoemulsification with IOL or one-site phacotrabeculectomy, between June 1997 and June 2001. The patients were matched for age group, operating list and IOL type. All patients were operated on under local anesthesia by the same surgeon. Each arm of the study had 90 patients, age range 60 to 75 years. We collected pre- and postoperative visual acuity, pre- and postoperative refraction within six months after surgery, and intended refraction. The intraocular pressure control was not recorded, as it was not the aim of our study. Results In the phacotrabeculectomy group, 76.6% of patients achieved aimed spherical equivalent, 15.5% of patients had against-the-rule (ATR) astigmatism induced by the surgery, and 90% of the patients had best corrected visual acuity (BCVA) more than 6/12. In the temporal incision phacoemulsification group, 81.1% of patients achieved aimed spherical equivalent, 10% of the patients had induced ATR by the surgery and 95.55% of patients achieved BCVA more than 6/12. Conclusion In this study the visual outcome of the phacotrabeculectomy group did not differ significantly from the visual outcome of temporal approach phacoemulsification.
Repeated tuberculin testing does not induce false positive ELISPOT results

The Enzyme Linked ImmunoSpot (ELISPOT) is a new rapid T cell based blood test (otherwise known as an interferon-γ assay) for the diagnosis of latent tuberculosis infection.1–3 The commercially available form of the assay, T-SPOT® TB (Oxford Immunotec, Abingdon, UK) has European regulatory approval as an in vitro diagnostic test and is increasingly being used in clinical practice. The test is based on the enumeration of interferon-γ producing T cells which are specific for two highly antigenic proteins, early secretory antigenic target-6 (ESAT-6) and culture filtrate protein 10 (CFP-10). 1 These proteins are expressed by Mycobacterium tuberculosis but are absent from M bovis BCG vaccine. Hence, the test does not give false positive results in BCG vaccinated individuals.1–3 ESAT-6 and CFP-10 are, however, contained within tuberculin purified protein derivative (PPD). Since ELISPOT is a highly sensitive method for measuring even low numbers of antigen specific T cells,4 concerns have been raised as to whether repeated tuberculin skin tests might induce T cell responses to these specific antigens, resulting in false …
Analysis of an Asymptotic Preserving Scheme for the Euler-Poisson System in the Quasineutral Limit

In a previous work [P. Crispel, P. Degond, and M. -H. Vignal, J. Comput. Phys., 223 (2007), pp. 208-234], a new numerical discretization of the Euler-Poisson system was proposed. This scheme is “asymptotic preserving” in the quasineutral limit (i.e., when the Debye length $\varepsilon$ tends to zero), which means that it becomes consistent with the limit model when $\varepsilon \to 0$. In the present work, we show that the stability domain of the present scheme is independent of $\varepsilon$. This stability analysis is performed on the Fourier transformed (with respect to the space variable) linearized system. We show that the stability property is more robust when a space-decentered scheme is used (which brings in some numerical dissipation) rather than a space-centered scheme. The linearization is first performed about a zero mean velocity and then about a nonzero mean velocity. At the various stages of the analysis, our scheme is compared with more classical schemes and its improved stability property is outlined. The analysis of a fully discrete (in space and time) version of the scheme is also given. Finally, some considerations about a model nonlinear problem, the Burgers-Poisson problem, are also discussed.
Sexual Stimulation Increases the Survival of New Cells in the Accessory Olfactory Bulb of the Male Rat

Sexual behavior in rodents is modulated by the olfactory system. The olfactory bulb (OB) is a structure that undergoes continues neurogenesis in adulthood. We have previously shown that 15 days after males rats pace the sexual interaction and ejaculate 1 or 3 times, there is an increase in the density of new cells that reach the accessory olfactory bulb (AOB). The aim of the present study was to evaluate if sexual behavior in male rats increases the density of new neurons that survive 45 days after sexual behavior in the AOB and in the main OB (MOB). Male rats were randomly divided in four groups: (1) Control (Ctr), males without sexual interaction; (2) Exposed (Exp), males only exposed to a sexually receptive female; (3) No pacing (NP), males that mated in conditions in which the female paced the sexual interaction; (4) One ejaculation (1E), males that paced the sexual interaction with a receptive female and ejaculated once; and (5) Three ejaculations (3E), males that paced the sexual interaction and were allowed to ejaculate three times. All males were injected with the DNA synthesis marker 5-bromo-2-deoxyuridine (BrdU), and were tested in one of the above conditions. 45 days later they were sacrificed, and the OBs were processed to identify new cells and evaluate if they had differentiated into neurons. Our data indicate that males that ejaculated three times showed an increase in the density of new cells that survive in the posterior part of the granular cell layer of the AOB and have more new neurons that the control group. However, no significant differences were found in the percentage of new cells that differentiate into neurons. No significant increase in the density of new cells was observed in the MOB. Our data show that pacing the sexual interaction until three ejaculations increases the density of new cells and neurons in the granular layer of the AOB, confirming that sexual behavior induces long-lasting plastic changes in the OB.
Sources of Euro Real Exchange Rate Fluctuations: What Is Behind the Euro Weakness in 1999-2000?

This paper analyzes the factors underlying the weakness of the euro. For this purpose, the framework advocated by Clarida and Gali (1994) is used. Within this model, three structural shocks drive the dynamics of the endogenous variables: aggregate supply shocks, aggregate spending shocks, and monetary shocks. Applying a structural VAR to data for the eurozone and the U.S. suggests that supply shocks are the most important factor explaining real exchange rate fluctuations in the sample from 1980 to 2000. However, historical decompositions reveal that fluctuations since the introduction of the euro in 1999 have been predominantly driven by demand shocks.
Learning Multiple Description Logics Concepts

Description logics based languages have became the standard representation scheme for ontologies. They formalize the domain knowledge using interrelated concepts, contained in terminologies. The manual definition of terminologies is an expensive and error prone task, therefore automatic learning methods are a necessity. In this paper we lay the foundations of a multiple concept learning method that uses virtual concepts to aid the learning process, yielding more compact and readable terminologies. In this paper, we define virtual concepts and how they can be implemented in the current concept learning methods. We show through experiments how the method stacks up against other multiple concept learning methods.
Analysis, approximations and admission control of a multi-service multiplexing system with priorities

We consider an ATM system with an architecture which is designed to accommodate users with very different quality of service requirements. Sources which belong to a high priority class share a FCFS buffer, which has priority access to the trunk. A low priority class of sources have a separate FCFS buffer, which receives the residual bandwidth, if any. By administering admission control the service guarantees for both classes may be satisfied. The sources are bursty and stochastic fluid models are used to handle burst-scale congestion effects. We develop simple, fast and robust analytic approximations for the queue distributions in the two buffers. We calculate the admissible set by using our analytic approximations and find that it is reasonably accurate and a conservative approximation to the correct set. The key element in our analysis is a characterization of the output of the high priority buffer as another Markov-modulated fluid source. A refinement to the now well known effective bandwidth approximation is used to calculate buffer content distributions.
Confidence Intervals for Standardized Effect Sizes: Theory, Application, and Implementation

The behavioral, educational, and social sciences are undergoing a paradigmatic shift in methodology, from disciplines that focus on the dichotomous outcome of null hypothesis significance tests to disciplines that report and interpret effect sizes and their corresponding confidence intervals. Due to the arbitrariness of many measurement instruments used in the behavioral, educational, and social sciences, some of the most widely reported effect sizes are standardized. Although forming confidence intervals for standardized effect sizes can be very beneficial, such confidence interval procedures are generally difficult to implement because they depend on noncentral t, F, and x2 distributions. At present, no main-stream statistical package provides exact confidence intervals for standardized effects without the use of specialized programming scripts. Methods for the Behavioral, Educational, and Social Sciences (MBESS) is an R package that has routines for calculating confidence intervals for noncentral t, F, and x2 distributions, which are then used in the calculation of exact confidence intervals for standardized effect sizes by using the confidence interval transformation and inversion principles. The present article discusses the way in which confidence intervals are formed for standardized effect sizes and illustrates how such confidence intervals can be easily formed using MBESS in R.