Miracle-dz/UniFAR-FTUs huggingface dataset:
Phylogenomics of Lophotrochozoa with Consideration of Systematic Error

&NA; Phylogenomic studies have improved understanding of deep metazoan phylogeny and show promise for resolving incongruences among analyses based on limited numbers of loci. One region of the animal tree that has been especially difficult to resolve, even with phylogenomic approaches, is relationships within Lophotrochozoa (the animal clade that includes molluscs, annelids, and flatworms among others). Lack of resolution in phylogenomic analyses could be due to insufficient phylogenetic signal, limitations in taxon and/or gene sampling, or systematic error. Here, we investigated why lophotrochozoan phylogeny has been such a difficult question to answer by identifying and reducing sources of systematic error. We supplemented existing data with 32 new transcriptomes spanning the diversity of Lophotrochozoa and constructed a new set of Lophotrochozoa‐specific core orthologs. Of these, 638 orthologous groups (OGs) passed strict screening for paralogy using a tree‐based approach. In order to reduce possible sources of systematic error, we calculated branch‐length heterogeneity, evolutionary rate, percent missing data, compositional bias, and saturation for each OG and analyzed increasingly stricter subsets of only the most stringent (best) OGs for these five variables. Principal component analysis of the values for each factor examined for each OG revealed that compositional heterogeneity and average patristic distance contributed most to the variance observed along the first principal component while branch‐length heterogeneity and, to a lesser extent, saturation contributed most to the variance observed along the second. Missing data did not strongly contribute to either. Additional sensitivity analyses examined effects of removing taxa with heterogeneous branch lengths, large amounts of missing data, and compositional heterogeneity. Although our analyses do not unambiguously resolve lophotrochozoan phylogeny, we advance the field by reducing the list of viable hypotheses. Moreover, our systematic approach for dissection of phylogenomic data can be applied to explore sources of incongruence and poor support in any phylogenomic data set. [Annelida; Brachiopoda; Bryozoa; Entoprocta; Mollusca; Nemertea; Phoronida; Platyzoa; Polyzoa; Spiralia; Trochozoa. ]
Primary auditory cortex regulates threat memory specificity

Distinguishing threatening from nonthreatening stimuli is essential for survival and stimulus generalization is a hallmark of anxiety disorders. While auditory threat learning produces long-lasting plasticity in primary auditory cortex (Au1), it is not clear whether such Au1 plasticity regulates memory specificity or generalization. We used muscimol infusions in rats to show that discriminatory threat learning requires Au1 activity specifically during memory acquisition and retrieval, but not during consolidation. Memory specificity was similarly disrupted by infusion of PKMζ inhibitor peptide (ZIP) during memory storage. Our findings show that Au1 is required at critical memory phases and suggest that Au1 plasticity enables stimulus discrimination.
The microphysics of clouds over the Antarctic Peninsula - Part 2: modelling aspects within Polar WRF

The first intercomparisons of cloud microphysics schemes implemented in the Weather Research and Forecasting (WRF) mesoscale atmospheric model (version 3.5.1) are performed in the Antarctic Peninsula using the polar version of WRF (Polar WRF) at 5 km resolution, along with comparisons to the British Antarctic Survey's aircraft measurements (presented in Part 1 of this work, Lachlan-Cope et al., 2016). This study follows previous works suggesting the misrepresentation of the cloud thermodynamic phase in order to explain large radiative biases derived at the surface in Polar WRF continent-wide, and in the Polar WRF-based operational forecast model Antarctic Mesoscale Prediction System (AMPS) over the Larsen C Ice shelf. Several cloud microphysics schemes are investigated: the WRF Single-Moment 5-class scheme (WSM5), the WRF Double-Moment 6-class scheme (WDM6), the Morrison double-moment scheme, the Thompson scheme, and the Milbrandt- Yau Double-Moment 7-class scheme. WSM5 used in AMPS struggles the most to capture the observed supercooled liquid phase mainly because of their ice nuclei parameterisation overestimating the number of activated crystals, while other micro- physics schemes (but not WSM5's upgraded version, WDM6) manage much better to do so. The best performing scheme is the Morrison scheme for its better average prediction of occurrences of clouds, and cloud phase, as well as its lowest surface radiative bias over the Larsen C ice shelf in the infrared. This is important for surface energy budget consideration with Polar WRF since the cloud radiative effect is more pronounced in the infrared over icy surfaces. However, our investigation shows that all the schemes fail at simulating the supercooled liquid mass at some temperatures (altitudes) where observations show evidence of its persistence. An ice nuclei parameterisation relying on both temperature and aerosol content like DeMott et al. (2010) (not currently used in WRF cloud schemes) is in best agreement with the observations, at temperatures and aerosol concentration characteristic of the Antarctic Peninsula where the primary ice production occurs (Part 1), compared to parame- terisation only relying on the atmospheric temperature (used by the WRF cloud schemes). Overall, a realistic ice microphysics implementation is paramount to the correct representation of the supercooled liquid phase in Antarctic clouds.
An Improved Frequency Domain Turbo Equalizer for Single-Carrier Spatial Modulation Systems

In this paper, a new time-domain soft-decision feedback (TDSDF) aided frequency domain turbo equalizer (FDTE) is proposed for broadband single-carrier (SC) spatial modulation (SM) systems. Specifically, the proposed equalizer operates on a frame-by-frame basis and is designed based on the minimum block-averaged mean-square error (MBMSE) criterion. To tackle the error propagation problem, a metric in consideration of the reliability of the feedback information is considered. The optimal coefficients of the forward and feedback filters involved in the TDSDF-FDTE design are derived analytically. Simulation results show that the proposed nonlinear TDSDF-FDTE detector is capable of offering a better tradeoff between the bit-error-rate (BER) performance and the imposed computational complexity than the conventional linear frequency domain turbo demapper (FDTD) conceived for SC-SM systems. Furthermore, a 4 dB improvement is observed for the unbalanced channel.
Childhood adversities and first onset of psychiatric disorders in a national sample of US adolescents.

CONTEXT Although childhood adversities (CAs) are known to be highly co-occurring, most research examines their associations with psychiatric disorders one at a time. However, recent evidence from adult studies suggests that the associations of multiple CAs with psychiatric disorders are nonadditive, arguing for the importance of multivariate analysis of multiple CAs. To our knowledge, no attempt has been made to perform a similar kind of analysis among children or adolescents. OBJECTIVE To examine the multivariate associations of 12 CAs with first onset of psychiatric disorders in a national sample of US adolescents. DESIGN A US national survey of adolescents (age range, 13-17 years) assessing DSM-IV anxiety, mood, behavior, and substance use disorders and CAs. The CAs include parental loss (death, divorce, and other separations), maltreatment (neglect and physical, sexual, and emotional abuse), and parental maladjustment (violence, criminality, substance abuse, and psychopathology), as well as economic adversity. SETTING Dual-frame household-school samples. PARTICIPANTS In total, 6483 adolescent-parent pairs. MAIN OUTCOME MEASURES Lifetime DSM-IV disorders assessed using the World Health Organization Composite International Diagnostic Interview. RESULTS Overall, exposure to at least 1 CA was reported by 58.3% of adolescents, among whom 59.7% reported multiple CAs. The CAs reflecting maladaptive family functioning were more strongly associated than other CAs with the onset of psychiatric disorders. The best-fitting model included terms for the type and number of CAs and distinguished between maladaptive family functioning and other CAs. The CAs predicted behavior disorders most strongly and fear disorders least strongly. The joint associations of multiple CAs were subadditive. The population-attributable risk proportions across DSM-IV disorder classes ranged from 15.7% for fear disorders to 40.7% for behavior disorders. The CAs were associated with 28.2% of all onsets of psychiatric disorders. CONCLUSIONS Childhood adversities are common, highly co-occurring, and strongly associated with the onset of psychiatric disorders among US adolescents. The subadditive multivariate associations of CAs with the onset of psychiatric disorders have implications for targeting interventions to reduce exposure to CAs and to mitigate the harmful effects of CAs to improve population mental health.
Effects of Heat Stress on Construction Labor Productivity in Hong Kong: A Case Study of Rebar Workers

Global warming is bringing more frequent and severe heat waves, and the result will be serious for vulnerable populations such as construction workers. Excessive heat stress has profound effects on physiological responses, which cause occupational injuries, fatalities and low productivity. Construction workers are particularly affected by heat stress, because of the body heat production caused by physically demanding tasks, and hot and humid working conditions. Field studies were conducted between August and September 2016 at two construction training grounds in Hong Kong. Onsite wet-bulb globe temperature (WBGT), workers’ heart rate (HR), and labor productivity were measured and monitored. Based on the 378 data sets of synchronized environmental, physiological, construction labor productivity (CLP), and personal variables, a CLP-heat stress model was established. It was found that WBGT, percentage of maximum HR, age, work duration, and alcohol drinking habits were determining factors for predicting the CLP (adjusted R2 = 0.68, p < 0.05). The model revealed that heat stress reduces CLP, with the percentage of direct work time decreasing by 0.33% when the WBGT increased by 1 °C. The findings in this study extend the existing practice notes by providing scientific data that may be of benefit to the industry in producing solid guidelines for working in hot weather.
Near-Infrared Fluorescence Lymphatic Imaging to Reconsider Occlusion Pressure of Superficial Lymphatic Collectors in Upper Extremities of Healthy Volunteers

Abstract Background: There are very little scientific data on occlusion pressure for superficial lymphatic collectors. Given its importance in determining the transport capacity of lymphatic vessels, it is crucial to know its value. The novel method of near-infrared fluorescence lymphatic imaging (NIRFLI) can be used to visualize lymphatic flow in real time. The goal of this study was to see if this method could be used to measure the lymphatic occlusion pressure. Methods: We observed and recorded lymph flow in the upper limb of healthy volunteers through a transparent cuff using near-infrared fluorescence lymphatic imaging. After obtaining a baseline of the lymph flow without pressure inside the cuff, the cuff was inflated by increments of 10 mm Hg starting at 30 mm Hg. A NIRFLI guided manual lymphatic drainage technique named “Fill & Flush Drainage Method” was performed during the measurement to promote lymph flow. Lymphatic occlusion pressure was determined by observing when lymph flow stopped under the cuff. Results: We measured the lymphatic occlusion pressure on 30 healthy volunteers (11 men and 19 women). Mean lymphatic occlusion pressure in the upper limb was 86 mm Hg (CI ±3.7 mm Hg, α = 0.5%). No significant differences were found between age groups (p = 0.18), gender (p = 0.12), or limb side (p = 0.85). Conclusions: NIRFLI, a transparent sphygmomanometer cuff and the “Fill and Flush” manual lymphatic drainage method were used to measure the lymphatic occlusion pressure in 30 healthy humans. That combination of these techniques allows the visualization of the lymph flow in real time, while ensuring the continuous filling of the lymph collectors during the measurement session, reducing false negative observations. The measured occlusion pressures are much higher than previously described in the medical literature.
Prevention case management improves socioeconomic standing and reduces symptoms of psychological and emotional distress among transgender women

Abstract Urban transgender women often experience several sociocultural co-factors which contribute to their risk of HIV infection. A transgender-specific HIV Prevention Case Management (PCM) intervention was implemented in a community HIV prevention setting and targeted reducing sex work and homelessness, increasing legal employment and income, and reducing psychological and emotional distress symptoms. Sixty high-risk transgender women were enrolled in the ten-session PCM intervention. Participants completed approximately nine out of the ten sessions (M = 8.7; SD = 2.6) and six-month follow-up evaluations were completed with 97% of the participants. Findings from baseline to follow-up evaluations demonstrated a decrease in homelessness (31.0% vs. 10.3%, p<0.01), less reliance on exchange sex as a primary source of income (41.4% vs. 22.4%, p < 0.05), and significant decreases in symptom complaints across multiple Brief Symptom Inventory sub-scales, including depression, hostility, phobic anxiety, and psychoticism (all significant at p<0.05). Further, socioeconomic improvements following the intervention were significantly associated with psychological and emotional gains. The study suggests that adding a culturally appropriate PCM intervention in a community setting is beneficial in addressing co-factors for HIV infection as well as psychological and emotional distress symptoms among this extremely high-risk population.
Microstrip Magnetic Monopole and Dipole Antennas With High Directivity and a Horizontally Polarized Omnidirectional Pattern

Novel microstrip magnetic monopole and dipole antennas are proposed to achieve a high directivity along the elevation plane as well as a horizontally polarized omnidirectional pattern in the azimuth plane. The directivity of this microstrip magnetic monopole antenna is calculated by numerical integration; the results show that the directivity increases with the antenna length when the antenna resonates in the fundamental mode. However, simulation shows that the main beam is tilted away from the azimuth plane when the antenna length exceeds <inline-formula> <tex-math notation="LaTeX">$2\lambda $ </tex-math></inline-formula> due to high-order resonant mode interference. A solution is provided to suppress the second resonant mode and retain the radiation peak in the azimuth direction. The peak gain of the microstrip magnetic monopole is increased to 7.2 dBi when the antenna length is approximately <inline-formula> <tex-math notation="LaTeX">$3\lambda $ </tex-math></inline-formula>. A microstrip magnetic dipole antenna with an antenna length of <inline-formula> <tex-math notation="LaTeX">$6\lambda $ </tex-math></inline-formula> is also designed to obtain a higher gain of 9.7 dBi. The impedance bandwidths of the microstrip magnetic monopole and dipole antennas are 6.5% (2.37–2.52 GHz) and 7.3% (2.35–2.53 GHz), respectively. The proposed antennas produce maximum radiation in the azimuth direction and have horizontally polarized omnidirectional patterns in the azimuth plane.
Majority of 30-Day Readmissions After Intracerebral Hemorrhage Are Related to Infections

Background and Purpose— Infections are common after intracerebral hemorrhage, but little is known about the risk of serious infection requiring readmission after hospital discharge. Methods— To determine if infections are prevalent in patients readmitted within 30 days of discharge, we performed a retrospective cohort study of patients discharged from nonfederal acute care hospitals in California with a primary diagnosis of intracerebral hemorrhage between 2006 and 2010. We excluded patients who died during the index admission, were discharged against medical advice, or were not California residents. Our main outcome was 30-day unplanned readmission with primary infection–related International Classification of Diseases, Ninth Revision, Clinical Modification code. Results— There were 24 540 index intracerebral hemorrhage visits from 2006 to 2010. Unplanned readmissions occurred in 14.5% (n=3550) of index patients. Of 3550 readmissions, 777 (22%) had an infection-related primary diagnosis code. When evaluating primary and all secondary diagnosis codes, infection was associated with 1826 (51%) of readmissions. Other common diagnoses associated with readmission included stroke-related codes (n=840, 23.7%) and aspiration pneumonitis (n=154, 4.3%). The most common infection-related primary diagnosis codes were septicemia (n=420, 11.8%), pneumonia (n=124, 3.5%), urinary tract infection (n=141, 4.0%), and gastrointestinal infection (n=42, 1.2%). Patients with a primary infection–related International Classification of Diseases, Ninth Revision, Clinical Modification code on readmission had higher in-hospital mortality compared with other types of readmission (15.6% versus 8.0%, P<0.001). After controlling for other predictors of mortality, primary infection–related readmissions remained associated with in-hospital mortality (relative risk, 1.7; 95% confidence interval, 1.3–2.2). Conclusions— Infections are associated with a majority of 30-day readmissions after intracerebral hemorrhage and increased mortality. Efforts should be made to reduce infection-related complications after hospital discharge.
Key regulators of galectin–glycan interactions

Protein–ligand interactions serve as fundamental regulators of numerous biological processes. Among protein–ligand pairs, glycan binding proteins (GBPs) and the glycans they recognize represent unique and highly complex interactions implicated in a broad range of regulatory activities. With few exceptions, cell surface receptors and secreted proteins are heavily glycosylated. As these glycans often represent highly regulatable post‐translational modifications, alterations in glycosylation can fundamentally impact GBP recognition. Among GBPs, galectins in particular appear to engage a diverse set of glycan determinants to impact a broad range of biological processes. In this review, we will explore factors that impact galectin activity, including the effect of glycan modification on galectin–glycan interactions.
Safety and Efficacy of Extended Bevacizumab Therapy in Elderly (≥70 Years) Versus Younger Patients Treated for Newly Diagnosed Ovarian Cancer in the International ROSiA Study

Objective The single-arm ROSiA study explored an extended duration of frontline bevacizumab-containing therapy for ovarian cancer. Post hoc analyses explored safety and efficacy according to age. Patients and Methods After primary debulking surgery, patients with stage IIB–IV or grade 3 stage I–IIA ovarian cancer received 4–8 cycles of paclitaxel [weekly or every 3 weeks (q3w)], carboplatin AUC 5–6 q3w, and bevacizumab 15 (or 7.5) mg/kg q3w, followed by single-agent bevacizumab until progression or for up to 24 months. The primary end point was safety; progression-free survival (PFS) was a secondary end point. Results Of 1021 patients treated, 121 (12%) were aged 70 years or older and 44 (4%) were 75 years or older. Compared with younger patients, more patients aged 70 years or older had hypertension at baseline, stage IV disease, and Eastern Cooperative Oncology Group performance status 1 or above. Bevacizumab was continued for more than 15 months in 49% of older versus 53% of younger patients. Older patients experienced higher incidences of all-grade anemia (44% vs 32%), diarrhea (35% vs 25%), and asthenia (22% vs 12%), and grade ≥3 hypertension (41% vs 22%) and thromboembolic events (7% vs 2%) compared with younger patients. Fatal bevacizumab-related adverse events occurred in 1 (0.8%) older versus 5 (0.6%) younger patients. Median PFS was 23.7 (95% confidence interval, 18.6–27.9) versus 25.6 (95% confidence interval, 23.7–28.4) months in patients aged 70 or older versus those younger than 70 years, respectively. Conclusion Bevacizumab-treated patients aged 70 years or older had higher incidences of anemia, low-grade diarrhea, and asthenia, and grade ≥3 hypertension and thromboembolic events than those younger than 70 years, but no other relevant increase in toxicity. Median PFS of approximately 2 years is similar to that in younger patients despite the worse prognosis. Older age should not preclude bevacizumab therapy for ovarian cancer in carefully selected patients aged 70 years or older. Given the higher background hypertension prevalence, elderly patients should be monitored more closely while receiving bevacizumab.
Determinants of institutional delivery among young married women in Nepal: Evidence from the Nepal Demographic and Health Survey, 2011

Objectives To identify the determinants of institutional delivery among young married women in Nepal. Design Nepal Demographic and Health Survey (NDHS) data sets 2011 were analysed. Bivariate and multivariate logistic regression analyses were performed using a subset of 1662 ever-married young women (aged 15–24 years). Outcome measure Place of delivery. Results The rate of institutional delivery among young married women was 46%, which is higher than the national average (35%) among all women of reproductive age. Young women who had more than four antenatal care (ANC) visits were three times more likely to deliver in a health institution compared with women who had no antenatal care visit (OR: 3.05; 95% CI: 2.40 to 3.87). The probability of delivering in an institution was 69% higher among young urban women than among young women who lived in rural areas. Young women who had secondary or above secondary level education were 1.63 times more likely to choose institutional delivery than young women who had no formal education (OR: 1.626; 95% CI: 1.171 to 2.258). Lower use of a health institution for delivery was also observed among poor young women. Results showed that wealthy young women were 2.12 times more likely to deliver their child in an institution compared with poor young women (OR: 2.107; 95% CI: 1.53 to 2.898). Other factors such as the age of the young woman, religion, ethnicity, and ecological zone were also associated with institutional delivery. Conclusions Maternal health programs should be designed to encourage young women to receive adequate ANC (at least four visits). Moreover, health programs should target poor, less educated, rural, young women who live in mountain regions, are of Janajati ethnicity and have at least one child as such women are less likely to choose institutional delivery in Nepal.