Miracle-dz/UniFAR-FTUs huggingface dataset:
The perception of peripersonal space in right and left brain damage hemiplegic patients

Peripersonal space, as opposed to extrapersonal space, is the space that contains reachable objects and in which multisensory and sensorimotor integration is enhanced. Thus, the perception of peripersonal space requires combining information on the spatial properties of the environment with information on the current capacity to act. In support of this, recent studies have provided converging evidences that perceiving objects in peripersonal space activates a neural network overlapping with that subtending voluntary motor action and motor imagery. Other studies have also underlined the dominant role of the right hemisphere (RH) in motor planning and of the left hemisphere (LH) in on-line motor guiding, respectively. In the present study, we investigated the effect of a right or left hemiplegia in the perception of peripersonal space. 16 hemiplegic patients with brain damage to the left (LH) or right (RH) hemisphere and eight matched healthy controls performed a color discrimination, a motor imagery and a reachability judgment task. Analyses of response times and accuracy revealed no variation among the three groups in the color discrimination task, suggesting the absence of any specific perceptual or decisional deficits in the patient groups. In contrast, the patient groups revealed longer response times in the motor imagery task when performed in reference to the hemiplegic arm (RH and LH) or to the healthy arm (RH). Moreover, RH group showed longer response times in the reachability judgment task, but only for stimuli located at the boundary of peripersonal space, which was furthermore significantly reduced in size. Considered together, these results confirm the crucial role of the motor system in motor imagery task and the perception of peripersonal space. They also revealed that RH damage has a more detrimental effect on reachability estimates, suggesting that motor planning processes contribute specifically to the perception of peripersonal space.
Leishmania infantum Exoproducts Inhibit Human Invariant NKT Cell Expansion and Activation

Leishmania infantum is one of the major parasite species associated with visceral leishmaniasis, a severe form of the disease that can become lethal if untreated. This obligate intracellular parasite has developed diverse strategies to escape the host immune response, such as exoproducts (Exo) carrying a wide range of molecules, including parasite virulence factors, which are potentially implicated in early stages of infection. Herein, we report that L. infantum Exo and its two fractions composed of extracellular vesicles (EVs) and vesicle-depleted-exoproducts (VDEs) inhibit human peripheral blood invariant natural killer T (iNKT) cell expansion in response to their specific ligand, the glycolipid α-GalactosylCeramide (α-GalCer), as well as their capacity to promptly produce IL-4 and IFNγ. Using plate-bound CD1d and α-GalCer, we found that Exo, EV, and VDE fractions reduced iNKT cell activation in a dose-dependent manner, suggesting that they prevented α-GalCer presentation by CD1d molecules. This direct effect on CD1d was confirmed by the observation that CD1d:α-GalCer complex formation was impaired in the presence of Exo, EV, and VDE fractions. Furthermore, lipid extracts from the three compounds mimicked the inhibition of iNKT cell activation. These lipid components of L. infantum exoproducts, including EV and VDE fractions, might compete for CD1-binding sites, thus blocking iNKT cell activation. Overall, our results provide evidence for a novel strategy through which L. infantum can evade immune responses of mammalian host cells by preventing iNKT lymphocytes from recognizing glycolipids in a TCR-dependent manner.
Persistence to the Baccalaureate Degree for Students Who Transfer from Community College

This article investigates the probability of attaining a baccalaureate degree for students who enrolled in community college after high school graduation and subsequently transferred to a four-year college. With logistic regression methods, this probability is compared with that of their counterparts who entered four-year institutions directly from high school. Using four waves of data from the high school class of 1980 from High School and Beyond, we compared the random sample of 422 transfer students with the sample of 1,899 four-year college students to determine the relative probabilities of their college graduation by 1986. Even though community college transfer students were from families of lower social class and were less likely to engage in behaviors that demonstrated their integration into the academic and social aspects of their college experiences, the probability of attaining the baccalaureate degree by 1986 was equivalent for the two groups (69 percent). The groups did not differ, moreover, in the relative likelihoods of either their aspiring to, or being enrolled in, graduate school. The authors explore probable reasons why their findings depart sharply from the conclusions of previous research on this topic, as prior studies have consistently decried the disadvantages of community college attendance on the subsequent educational attainment of their students.
A review of curriculum in the UK: internationalising in a changing context

The present article focuses on the growing emphasis on international dimensions of the curriculum in the UK. Educators and policymakers increasingly grapple with the thorny issue of how best to prepare future generations for life in a world changing so rapidly that no-one is able to predict precisely what knowledge and skills will be relevant for the adult of tomorrow. Overlapping with debate relating to the national context is that pertaining to the global environment, which manifests itself in current educational discourse relating to a growing number of concepts such as global citizenship education, international education, development education, world studies, and education for international understanding. Beginning with consideration of the curriculum context, this article highlights the growing number of international curriculum programmes being developed and offered worldwide, and in the UK in particular, before considering some of the reasons behind this growth and the implications of increased interest in programmes with an international focus.
Optimal Capacity Allocation for Executing MapReduce Jobs in Cloud Systems

Nowadays, analyzing large amount of data is of paramount importance for many companies. Big data and business intelligence applications are facilitated by the MapReduce programming model while, at infrastructural layer, cloud computing provides flexible and cost effective solutions for allocating on demand large clusters. Capacity allocation in such systems is a key challenge to providing performance for MapReduce jobs and minimize cloud resource cost. The contribution of this paper is twofold: (i) we formulate a linear programming model able to minimize cloud resources cost and job rejection penalties for the execution of jobs of multiple classes with (soft) deadline guarantees, (ii) we provide new upper and lower bounds for MapReduce job execution time in shared Hadoop clusters. Moreover, our solutions are validated by a large set of experiments. We demonstrate that our method is able to determine the global optimal solution for systems including up to 1000 user classes in less than 0.5 seconds. Moreover, the execution time of MapReduce jobs are within 19% of our upper bounds on average.
Survey of Occupational Stress of Secondary and Elementary School Teachers and the Lessons Learned

Based on the measuring instruments used by scholars in China and abroad, we devised a questionnaire to study occupational stress of 500 secondary and elementary school teachers in Tacheng municipality in Xinjiang and examined its negative effects on teachers. They found that the occupational stress of secondary and elementary school teachers are considerable and affected their health and performance. The negative effects of occupational stress on teachers' health are markedly greater than the effects on work. There are significant gender differences in the occupational stress among teachers in different schools and with different lengths of service. We conclude that occupational stress is considerable among secondary and elementary school teachers and affects their health and work performance.
Beyond coping? Alternatives to consumption within a social network of Russian workers

Research on the post-socialist lived experience of the working poor often focuses on reciprocity and economic survival. It is equally important to examine how social networks facilitate self-provisioning and mutual-aid practices for non-subsistence consumption (decorative, non-utility items) in the face of material want. The ethnography presented here of manufacturing workers in a Russian province shows how self-resourced homemaking and decorative practices, after MacIntyre (1981), constitute an ‘internal good’ – a social activity valued for itself as much as the domestic production it results in. This good is important for workers’ mutual recognition as providers and their status as sufficiently resourceful subjects suitable for inclusion within a social network – itself an important resource for the working poor. The network provides opportunities for alternatives to consumption outside the market economy. Worker identities at work cannot be detached from those at leisure and at home, and even the meaning of the workplace is problematized by its special place within the network.
The concept of action learning

This paper reviews the concept of action learning with reference to the classic texts by Reg Revans and texts that are likely to become classics, such as recent studies from the UK, Germany, Austria, South Africa, Australia, North America and Latin America. Action learning is now an international field and this paper draws widely from this field. The paper focuses on defining the concept of action learning and revealing its underlying philosophical assumptions. The terminology, features and success factors of an action learning program are also considered.
Hon‐ouring the past: play‐publics and gender at Baltimore’s HonFest

Baltimore, Maryland’s annual HonFest, has been criticized for its caricatured portrayal of the Baltimore Hon, a white working‐class woman from the mid‐twentieth century. Created to promote local businesses, the event seeks to draw tourists to a gentrifying neighbourhood. However, for a core group of Hon re‐enactors a shared definition of working‐class femininity allows them to subvert the individualised consumption spurred by the event by creating ‘play‐publics’ in which groups of strangers interact in a public environment through play and then begin to discuss shared aspects of common histories due to that interaction. Often these personal memories about working‐class families and post‐war neighbourhoods express nostalgia for a time of community cohesiveness, while ignoring the racism that insured the homogeneity of such neighbourhoods. As a white icon, the Hon also erases the heritage of Baltimore’s African‐American majority. Nonetheless, this research demonstrates how an understanding of the relationship between gender and play can illuminate the subversive possibilities — and limitations— within the post‐industrial heritage production.
Cardiac [123I]metaiodobenzylguanidine scintigraphy for vascular Parkinsonism

The purpose of our study was to prospectively evaluate cardiac [123I]metaiodobenzylguanidine (MIBG) uptake in patients with cerebrovascular disease (CVD) who develop clinical symptoms of vascular Parkinsonism (VP). A total of 19 consecutive patients who developed Parkinsonism during the course of their CVD were enrolled in the study; 16 age‐matched subjects, and 30 patients with Parkinson's disease (PD) were also evaluated with cardiac MIBG uptake. MIBG uptake was assessed using the ratio of the heart to the upper mediastinum (H/M) according to planar scintigraphic data. The mean H/M ratio was significantly higher in patients with VP than in those with PD (2.28 ± 0.41 vs. 1.27 ± 0.13; P < 0.001). MIBG uptake did not differ between VP and controls (2.46 ± 0.33; P > 0.05). Our findings suggest that myocardial postganglionic sympathetic dysfunction found in PD is absent in most patients with VP. MIBG single photon emission computed tomography imaging may be useful to help distinguish between PD and VP patients in clinical practice. © 2006 Movement Disorder Society
Le mythe de Ferry une analyse cliométrique

The development of education (essentially primary schooling) has been considered since the beginning of the nineteenth century as a major process and notably characteristic of developed capitalist societies. This being so, in spite of abundant literature devoted to this extremely delicate subject for more than 50years, there has still been no in-depth, quantitative research on the origin of the phenomenon and above all on the historical process that led to it. French research since the end of World War 2 in particular, with fresh work in the field of research on education, has generally merely noted this development, considering the interpretation to be obvious. We have a different conception, considering that the increase in school attendance in France requires a fresh conceptual approach and new empirical and theoretical validation work. For this, our cliometric study of the convergence process of primary education by administrative department in France before the Ferry laws is based on retrospective national accounts and econometric methods.
Laparoscopic biliary bypass--a single centre experience.

BACKGROUND/AIMS To review the results of laparoscopic biliary bypass for both benign and malignant pathologies in a minimal access surgery training center. METHODOLOGY Retrospective review of a prospectively maintained database of laparoscopic biliary bypass during the period 1995-2004. RESULTS During the review period 1995-2004, there were 26 laparoscopic biliary bypasses performed in our center which included 23 laparoscopic choledochoduodenostomy (LCD), 2 laparoscopic roux-en-Y choledochojejunostomy (LCJ) and 1 laparoscopic cholecystojejunostomy (LCCJ). Of the 23 LCD, all except 1 patient were operated for recurrent pyogenic cholangitis (RPC). The 2 LCJ and 1 LCCJ were performed for patients with advanced carcinoma in the periampullary region and simultaneous laparoscopic gastrojejunostomy (LGJ) was also performed to relieve the gastric outflow obstruction. Among the 23 LCD, there were 2 open conversions (7.7%) for lost broken tip of ultrasonic dissector and significant bleeding during choledochotomy respectively. Major complications occurred in 6 patients (23%), which included 3 bile leaks (11.5%), 1 intraabdominal collection (3.8%). 1 wound infection (3.8%) and 1 gastric stasis (3.8%). The only mortality in our series was a patient with carcinoma of head of pancreas undergoing simultaneous roux-en-Y LCCJ and LGJ. He had persistent gastric stasis after operation and required revision surgery for the kinked cholecystojejunostomy anastomosis. He finally died of myocardial ischemia after the second operation. As for the postoperative pain control, the mean pethidine consumption was 243.4 +/- 254.7 mg (range 0-1200 mg) and mean dologesic usage was 16.2 +/- 20.4 tablets (range 0-94 tablets). The average postoperative hospital stay was 12.6 +/- 11.5 days (range 5-60 days). The long-term functional results were satisfactory and only 1 patient had recurrent stone upon a mean follow-up of 32.3 months. Among the patients with malignant biliary obstruction, the only mishap was as previously mentioned and the remaining 2 patients could enjoy satisfactory palliation for more than a year before death. CONCLUSIONS Laparoscopic bypass is not only feasible but also highly effective in relieving biliary obstruction with good postoperative results in both benign and malignant conditions.
Effect of epidural analgesia on metabolic profiles during and after surgery

Blood concentrations of glucose, lactate, alanine, free fatty acids, glycerol and 3‐hydroxybutyrate were measured during 24 h in 12 females undergoing elective hysterectomy under either general anaesthesia or epidural analgesia extending from T4 to S5. The results showed that the peroperative and immediate postoperative metabolic profiles in the group receiving general anaesthesia reflected substrate mobilization (increased glucose, lactate, 3‐hydroxybutyrate), and that epidural analgesia blocked these changes, probably mediated through an inhibited adrenaline response to surgery. Peroperative values of free fatty acids and glycerol were significantly lowered by epidural analgesia, indicating inhibition of lipolysis. Alanine decreased similarly in both groups. In the later postoperative period metabolic profiles were similar in the two groups, indicating that the influence of fasting may override the effect of the relatively minor trauma.
RELEASE OF CARTILAGE MUCOPOLYSACCHARIDE-DEGRADING NEUTRAL PROTEASE FROM HUMAN LEUKOCYTES

The granule fraction of human leukocytes contains neutral protease capable of degrading the noncollagenous protein mucopolysaccharide matrix of cartilage at neutral pH in physiological salt solution. Cartilage degradation was monitored by quantitating the release of 35S from labeled rabbit ear cartilage. Degradation of cartilage matrix occurs when intact viable human leukocytes are incubated with cartilage opsonized with aggregated human gamma globulin (AHGG). During a similar 4 h incubation period cells did not degrade uncoated cartilage or cartilage coated with nonaggregated gamma globulin. Cells remain viable during the enzyme release process as evidenced by the absence of a cytoplasmic enzyme marker (lactic dehydrogenase) in the supernatant and dye exclusion studies. The release of 35S from labeled cartilage by human leukocytes in the presence of cartilage coated with AHGG (nonphagocytic enzyme release) was compared with the cartilage degrading activity of the supernatant from the same number of cells preincubated with a suspension of AHGG (phagocytic enzyme release). Nonphagocytic enzyme release by 5 x 106 cells provoked two to four times more 35S and β-glucuronidase (β-G) release from cartilage than phagocytic enzyme release conditions. β-glucuronidase was used as an indicator of the release of lysosomal granule enzymes. By the use of selected pharmacological agents it was possible to dissociate the enzyme release process from intrinsic enzyme (neutral protease) activity. Neutral protease and β-G release by human cells in the presence of AHGG-coated cartilage was inhibited by 10–5M colchicine, whereas the protease activity, but not the release process, was inhibited by 10–6M gold thiomalate and 10% human serum. It is suggested that the release of a cartilage degrading neutral protease by viable human cells when exposed to AHGG might be a relevant model for the study of cartilage destruction as it occurs in rheumatoid arthritis.
Comparative effects of risedronate and calcitriol on cancellous bone in rats with glucocorticoid-induced osteopenia.

OBJECTIVES To compared the effects of risedronate (Ris) and calcitriol (Cal) on cancellous bone in rats with glucocorticoid (GC)-induced osteopenia. MATERIALS AND METHODS Thirty female Sprague-Dawley rats, 4 mo of age, were randomly divided by the stratified weight method into three groups of 10 rats each according to the following treatment schedule: 8-wk GC administration with 4-wk vehicle (control), Ris, and Cal as therapeutic treatment initiated after 4-wk GC administration. The GC (methylprednisolone sodium succinate, 5.0 mg/kg, s.c.), Ris (10 microg/kg, s.c.), and Cal (0.1 microg/kg. p.o.) were administered 3 times a week. At the end of the 8-wk treatment period, two-dimensional (2D) bone histomorphometric analysis was performed for cancellous bone of the proximal tibial metaphysis, 3D micro-computed tomographic analysis was performed for the distal femoral metaphysis, and the mechanical strength of the distal femoral metaphysis was evaluated by a compression test. RESULTS Ris and Cal treatment increased both 2D and 3D cancellous bone mass. However, Ris treatment exhibited more pronounced effects on 2D and 3D cancellous bone mass than Cal treatment, and the effects of both Ris and Cal treatment were greater on 3D cancellous bone mass than on 2D cancellous bone mass. The response of 2D and 3D cancellous bone mass to Ris treatment was characterized by its effect on trabecular number and thickness, which was associated with markedly suppressed bone resorption and bone formation in terms of suppressed bone turnover. On the other hand, the response of 2D cancellous bone mass to Cal treatment was attributed to the effect of Cal on 2D trabecular thickness, and the response of 3D cancellous bone mass to Cal treatment might be characterized by the effect of Cal on 3D trabecular number and thickness, with a more marked effect of trabecular thickness. These effects were primarily due to mildly suppressed bone resorption and maintained or even increased bone formation. Despite the differential effect of Ris and Cal treatment on the cancellous bone structure and bone metabolism, both treatment increased the maximum load and braking energy of the distal femoral metaphysis to a similar extent, suggesting different mechanisms for improving bone strength. CONCLUSIONS This study showed the differential effects of Ris and Cal on cancellous bone in rats with GC-induced osteopenia.
Targeting Human Papillomavirus to Reduce the Burden of Cervical, Vulvar and Vaginal Cancer and Pre-Invasive Neoplasia: Establishing the Baseline for Surveillance

Background Infection with high-risk human papillomavirus (HPV) is causally related to cervical, vulvar and vaginal pre-invasive neoplasias and cancers. Highly effective vaccines against HPV types 16/18 have been available since 2006, and are currently used in many countries in combination with cervical cancer screening to control the burden of cervical cancer. We estimated the overall and age-specific incidence rate (IR) of cervical, vulvar and vaginal cancer and pre-invasive neoplasia in Denmark, Iceland, Norway and Sweden in 2004–2006, prior to the availability of HPV vaccines, in order to establish a baseline for surveillance. We also estimated the population attributable fraction to determine roughly the expected effect of HPV16/18 vaccination on the incidence of these diseases. Methods Information on incident cervical, vulvar and vaginal cancers and high-grade pre-invasive neoplasias was obtained from high-quality national population-based registries. A literature review was conducted to define the fraction of these lesions attributable to HPV16/18, i.e., those that could be prevented by HPV vaccination. Results Among the four countries, the age-standardised IR/105 of cervical, vaginal and vulvar cancer ranged from 8.4–13.8, 1.3–3.1 and 0.2–0.6, respectively. The risk for cervical cancer was highest in women aged 30–39, while vulvar and vaginal cancers were most common in women aged 70+. Age-standardised IR/105 of cervical, vulvar and vaginal pre-invasive neoplasia ranged between 138.8−183.2, 2.5−8.8 and 0.5−1.3, respectively. Women aged 20−29 had the highest risk for cervical pre-invasive neoplasia, while vulvar and vaginal pre-invasive neoplasia peaked in women aged 40−49 and 60−69, respectively. Over 50% of the observed 47,820 incident invasive and pre-invasive cancer cases in 2004−2006 can be attributed to HPV16/18. Conclusion In the four countries, vaccination against HPV 16/18 could prevent approximately 8500 cases of gynecological cancer and pre-cancer annually. Population-based cancer and vaccination registries are essential to assess the predicted public health effects of HPV vaccination.