Miracle-dz/UniFAR-FTUs huggingface dataset:
An Accelerated Linearized Alternating Direction Method of Multipliers

We present a novel framework, namely, accelerated alternating direction method of multipliers (AADMM), for acceleration of linearized ADMM. The basic idea of AADMM is to incorporate a multistep acceleration scheme into linearized ADMM. We demonstrate that for solving a class of convex composite optimization with linear constraints, the rate of convergence of AADMM is better than that of linearized ADMM, in terms of their dependence on the Lipschitz constant of the smooth component. Moreover, AADMM is capable of dealing with the situation when the feasible region is unbounded, as long as the corresponding saddle point problem has a solution. A backtracking algorithm is also proposed for practical performance.
Bradykinin Produces Pain Hypersensitivity by Potentiating Spinal Cord Glutamatergic Synaptic Transmission

Bradykinin, an inflammatory mediator, sensitizes nociceptor peripheral terminals reducing pain threshold. We now show that the B2 kinin receptor is expressed in rat dorsal horn neurons and that bradykinin, a B2-specific agonist, augments AMPA- and NMDA-induced, and primary afferent-evoked EPSCs, and increases the frequency and amplitude of miniature EPSCs in superficial dorsal horn neurons in vitro. Administration of bradykinin to the spinal cord in vivo produces, moreover, an NMDA-dependent hyperalgesia. We also demonstrate that nociceptive inputs result in the production of bradykinin in the spinal cord and that an intrathecal B2-selective antagonist suppresses behavioral manifestations of central sensitization, an activity-dependent increase in glutamatergic synaptic efficacy. Primary afferent-evoked central sensitization is, in addition, reduced in B2 receptor knock-out mice. We conclude that bradykinin is released in the spinal cord in response to nociceptor inputs and acts as a synaptic neuromodulator, potentiating glutamatergic synaptic transmission to produce pain hypersensitivity.
The physics of stratum corneum lipid membranes

The stratum corneum (SC), the outermost layer of skin, comprises rigid corneocytes (keratin-filled dead cells) in a specialized lipid matrix. The continuous lipid matrix provides the main barrier against uncontrolled water loss and invasion of external pathogens. Unlike all other biological lipid membranes (such as intracellular organelles and plasma membranes), molecules in the SC lipid matrix show small hydrophilic groups and large variability in the length of the alkyl tails and in the numbers and positions of groups that are capable of forming hydrogen bonds. Molecular simulations provide a route for systematically probing the effects of each of these differences separately. In this article, we present the results from atomistic molecular dynamics of selected lipid bilayers and multi-layers to probe the effect of these polydispersities. We address the nature of the tail packing in the gel-like phase, the hydrogen bond network among head groups, the bending moduli expected for leaflets comprising SC lipids and the conformation of very long ceramide lipids in multi-bilayer lipid assemblies. This article is part of the themed issue ‘Soft interfacial materials: from fundamentals to formulation’.
EEG-based Speech Recognition: Impact of Experimental Design on Performance

Electroencephalography (EEG) has proven to be a valuable method for communication for speech-impaired persons. Recently, attempts have been made to use EEG data for the recognition of unspoken speech. Unspoken speech means that a subject thinks a given word without the use of the facial muscles and without uttering any audible sound. In spite of promising first results [40], the question has been raised in [9] whether the system may have recognized temporal patterns in the data instead of actual words since the words were presented in blocks. The contribution of this thesis is to investigate in depth the impact of experimental design on the recognition rate of unspoken speech. For this study, 23 subjects were recorded for 71 sessions in total, using a high-density EEG cap with 128 electrodes out of which 16 were recorded. The vocabulary domain consisted of 5 words each of which were repeated 20 times. Between sessions, the order in which the words were presented has been varied as well as the length of the breaks. Besides the previously used orders blocks, sequential and random, short blocks were tested consisting of blocks of 5 words. It could be shown that except for the block mode which yielded an average recognition rate of 45.50%, all other modes had recognition rates at chance level. This may be partially explained by the fact that block data contains less noise and the fact that this mode facilitates the task to think words in a consistent way. However, it could be shown that temporal artifacts indeed superimpose the signal of interest in block recordings.
Cooler Temperatures Destabilize RNA Interference and Increase Susceptibility of Disease Vector Mosquitoes to Viral Infection

Background The impact of global climate change on the transmission dynamics of infectious diseases is the subject of extensive debate. The transmission of mosquito-borne viral diseases is particularly complex, with climatic variables directly affecting many parameters associated with the prevalence of disease vectors. While evidence shows that warmer temperatures often decrease the extrinsic incubation period of an arthropod-borne virus (arbovirus), exposure to cooler temperatures often predisposes disease vector mosquitoes to higher infection rates. RNA interference (RNAi) pathways are essential to antiviral immunity in the mosquito; however, few experiments have explored the effects of temperature on the RNAi machinery. Methodology/Principal Findings We utilized transgenic “sensor” strains of Aedes aegypti to examine the role of temperature on RNA silencing. These “sensor” strains express EGFP only when RNAi is inhibited; for example, after knockdown of the effector proteins Dicer-2 (DCR-2) or Argonaute-2 (AGO-2). We observed an increase in EGFP expression in transgenic sensor mosquitoes reared at 18°C as compared with 28°C. Changes in expression were dependent on the presence of an inverted repeat with homology to a portion of the EGFP sequence, as transgenic strains lacking this sequence, the double stranded RNA (dsRNA) trigger for RNAi, showed no change in EGFP expression when reared at 18°C. Sequencing small RNAs in sensor mosquitoes reared at low temperature revealed normal processing of dsRNA substrates, suggesting the observed deficiency in RNAi occurs downstream of DCR-2. Rearing at cooler temperatures also predisposed mosquitoes to higher levels of infection with both chikungunya and yellow fever viruses. Conclusions/Significance This data suggest that microclimates, such as those present in mosquito breeding sites, as well as more general climactic variables may influence the dynamics of mosquito-borne viral diseases by affecting the antiviral immunity of disease vectors.
Discharging the Network From Its Flow Control Headaches: Packet Drops and HOL Blocking

Congestion control becomes indispensable in highly utilized consolidated networks running demanding applications. In this paper, proactive congestion management schemes for Clos networks are described and evaluated. The key idea is to move the congestion avoidance burden from the data fabric to a scheduling network, which isolates flows using per-flow request counters. The scheduling network comprises per-output arbiters that grant data packets after reserving space for them in the buffer memories in front of fabric outputs. Computer simulations show that this strategy eliminates head-of-line (HOL) blocking and its adversarial effects throughout the fabric, without having to drop packets. In particular, a simplified model describes this result as a synergy between proactive buffer reservations and fine-grained multipath routing. Two alternative designs are presented. The first one places all arbiters in a central control unit, is simpler, and has superior performance. The second is more scalable by distributing the arbiters over the switching elements of the Clos network and by routing the control messages to and from endpoint adapters via multiple paths. Computer simulations of the complete system demonstrate high throughput and low latency under any number of congested outputs. Weighted max-min fair allocation of fabric-output link bandwidth is also demonstrated. Furthermore, delay breakdowns show that the time that packets wait in fabric and resequencing buffers is minimized as a result of the reduced (and equalized across all fabric paths) in-fabric contention. Finally, the high throughput capability of the system is corroborated by a Markov chain analysis of output buffer credits.
The Association between Sulfonylurea Use and All-Cause and Cardiovascular Mortality: A Meta-Analysis with Trial Sequential Analysis of Randomized Clinical Trials

Background Sulfonylureas are an effective and inexpensive treatment for type 2 diabetes. There is conflicting data about the safety of these drugs regarding mortality and cardiovascular outcomes. The objective of the present study was to evaluate the safety of the sulfonylureas most frequently used and to use trial sequential analysis (TSA) to analyze whether the available sample was powered enough to support the results. Methods and Findings Electronic databases were reviewed from 1946 (Embase) or 1966 (MEDLINE) up to 31 December 2014. Randomized clinical trials (RCTs) of at least 52 wk in duration evaluating second- or third-generation sulfonylureas in the treatment of adults with type 2 diabetes and reporting outcomes of interest were included. Primary outcomes were all-cause and cardiovascular mortality. Additionally, myocardial infarction and stroke events were evaluated. Data were summarized with Peto odds ratios (ORs), and the reliability of the results was evaluated with TSA. Forty-seven RCTs with 37,650 patients and 890 deaths in total were included. Sulfonylureas were not associated with all-cause (OR 1.12 [95% CI 0.96 to 1.30]) or cardiovascular mortality (OR 1.12 [95% CI 0.87 to 1.42]). Sulfonylureas were also not associated with increased risk of myocardial infarction (OR 0.92 [95% CI 0.76 to 1.12]) or stroke (OR 1.16 [95% CI 0.81 to 1.66]). TSA could discard an absolute difference of 0.5% between the treatments, which was considered the minimal clinically significant difference. The major limitation of this review was the inclusion of studies not designed to evaluate safety outcomes. Conclusions Sulfonylureas are not associated with increased risk for all-cause mortality, cardiovascular mortality, myocardial infarction, or stroke. Current evidence supports the safety of sulfonylureas; an absolute risk of 0.5% could be firmly discarded. Review registration PROSPERO CRD42014004330
The Challenge of Fiscal Adjustment in a Democracy: The Case of India

India`s fiscal problem has deep roots in its federal fiscal system, where multiple players find it difficult to coordinate adjustment. The size and closed nature of the Indian economy, aided by its deep domestic capital market and large captive pool of domestic savings, has disguised the cost of fiscal laxity and complicated the building of a consensus on reform. The new fiscal responsibility act establishes a new rules-based system to overcome this coordination failure. To strengthen the framework, we recommend an autonomous scorekeeper and the extension of similar rules to the state governments as part of a comprehensive reform of the federal system.
Expression of the Glioma-Associated Oncogene Homolog 1 (Gli1) in Advanced Serous Ovarian Cancer Is Associated with Unfavorable Overall Survival

Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, glioblastoma, melanoma as well as pancreas, colorectal, and prostate carcinomas. Here we investigated the role of the transcription factor Gli1 in ovarian cancer. To this end, the expression profile of Gli1 was examined in normal ovaries, ovarian tumors, and ovarian cancer cell lines, and the in vitro effects of a specific Hh-pathway blocker, KAAD-cyclopamine, or a specific Gli1 inhibitor (GANT58) on cell proliferation and on Hh target gene expression were also assessed. Results obtained showed that epithelial cells in ovarian cancer tissue express significantly higher levels of nuclear Gli1 than in normal ovarian tissue, where the protein was almost undetectable. In addition, multivariate analysis showed that nuclear Gli1 was independently associated to poor survival in advanced serous ovarian cancer patients (HR = 2.2, 95%CI 1.0–5.1, p = 0.04). In vitro experiments demonstrated Gli1 expression in the three ovarian carcinoma cell lines tested, A2780, SKOV-3 and OVCAR-3. Remarkably, although KAAD-cyclopamine led to decreased cell proliferation, this treatment did not inhibit hedgehog target gene expression in any of the three ovarian cancer cell lines, suggesting that the inhibition of cell proliferation was a nonspecific or toxic effect. In line with these data, no differences on cell proliferation were observed when cell lines were treated with GANT58. Overall, our clinical data support the role of Gli1 as a prognostic marker in advanced serous ovarian cancer and as a possible therapeutic target in this disease. However, our in vitro findings draw attention to the need for selection of appropriate experimental models that accurately represent human tumor for testing future therapies involving Hh pathway inhibitors.
Competitive PCR reveals the complexity of postcopulatory sexual selection in Teleogryllus commodus

The outcome of mate choice depends on complex interactions between males and females both before and after copulation. Although the competition between males for access to mates and premating choice by females are relatively well understood, the nature of interactions between cryptic female choice and male sperm competition within the female reproductive tract is less clear. Understanding the complexity of postcopulatory sexual selection requires an understanding of how anatomy, physiology and behaviour mediate sperm transfer and storage within multiply mated females. Here we use a newly developed molecular technique to directly quantify mixed sperm stores in multiple mating females of the black field cricket, Teleogryllus commodus. In this species, female postcopulatory choice is easily observed and manipulated as females delay the removal of the spermatophore in favour of preferred males. Using twice‐mated females, we find that the proportion of sperm in the spermatheca attributed to the second male to mate with a female (S2) increases linearly with the time of spermatophore attachment. Moreover, we show that the insemination success of a male increases with its attractiveness and decreases with the size of the female. The effect of male attractiveness in this context suggests a previously unknown episode of mate choice in this species that reinforces the sexual selection imposed by premating choice and conflicts with the outcome of postmating male harassment. Our results provide some of the clearest evidence yet for how sperm transfer and displacement in multiply mated females can lead directly to cryptic female choice, and that three distinct periods of sexual selection operate in black field crickets.
Rethinking the Intercept Probability of Random Linear Network Coding

This letter considers a network comprising a transmitter, which employs random linear network coding to encode a message, a legitimate receiver, which can recover the message if it gathers a sufficient number of linearly independent coded packets, and an eavesdropper. Closed-form expressions for the probability of the eavesdropper intercepting enough coded packets to recover the message are derived. Transmission with and without feedback is studied. Furthermore, an optimization model that minimizes the intercept probability under delay and reliability constraints is presented. Results validate the proposed analysis and quantify the secrecy gain offered by a feedback link from the legitimate receiver.
Position-Independent Code Reuse: On the Effectiveness of ASLR in the Absence of Information Disclosure

Address-space layout randomization is a wellestablished defense against code-reuse attacks. However, it can be completely bypassed by just-in-time code-reuse attacks that rely on information disclosure of code addresses via memory or side-channel exposure. To address this fundamental weakness, much recent research has focused on detecting and mitigating information disclosure. The assumption being that if we perfect such techniques, we will not only maintain layout secrecy but also stop code reuse. In this paper, we demonstrate that an advanced attacker can mount practical code-reuse attacks even in the complete absence of information disclosure. To this end, we present Position-Independent Code-Reuse Attacks, a new class of codereuse attacks relying on the relative rather than absolute location of code gadgets in memory. By means of memory massaging, the attacker first makes the victim program generate a rudimentary ROP payload (for instance, containing code pointers that target instructions "close" to relevant gadgets). Afterwards, the addresses in this payload are patched with small offsets via relative memory writes. To establish the practicality of such attacks, we present multiple Position-Independent ROP exploits against real-world software. After showing that we can bypass ASLR in current systems without requiring information disclosures, we evaluate the impact of our technique on other defenses, such as fine-grained ASLR, multi-variant execution, execute-only memory and re-randomization. We conclude by discussing potential mitigations.
Susceptibility to Tolerogenesis Governs Their Immunogenicity and Primary Vascularization of Allografts

We investigated the inﬂuence of allograft primary vascularization on alloimmunity, rejection, and tolerance in mice. First, we showed that fully allogeneic primarily vascularized and conventional skin transplants were rejected at the same pace. Remarkably, however, short-term treatment of mice with anti-CD40L Abs achieved long-term survival of vascularized skin and cardiac transplants but not conventional skin grafts. Nonvascularized skin transplants triggered vigorous direct and indirect proinﬂammatory type 1 T cell responses (IL-2 and IFN- g ), whereas primarily vascularized skin allografts failed to trigger a signiﬁcant indirect alloresponse. A similar lack of indirect alloreactivity was also observed after placement of different vascularized organ transplants, including hearts and kidneys, whereas hearts placed under the skin (nonvascularized) triggered potent indirect alloresponses. Altogether, these results suggest that primary vascularization of allografts is associated with a lack of indirect T cell alloreactivity. Finally, we show that long-term survival of vascularized skin allografts induced by anti-CD40L Abs was associated with a combined lack of indirect alloresponse and a shift of the direct alloresponse toward a type 2 cytokine (IL-4, IL-10)-secretion pattern but no activation/expansion of Foxp3 + regulatory T cells. Therefore, primary vascularization of allografts governs their immunogenicity and tolerogenicity. The Journal of Immunology , 2013, 191: 000–000. early cells the
Cellular microparticles in the pathogenesis of pulmonary hypertension

Pulmonary hypertension (PH) is a fatal disease with no treatment options, characterised by elevated pulmonary vascular resistanzce and secondary right ventricular failure. The aetiology of pulmonary arterial hypertension is multiple and its pathogenesis is complex. Although the exact role of cellular microparticles remains partially understood, there is increasing evidence to suggest an active role for microparticles in PH pathophysiology. Patients with PH exhibited higher circulating levels of microparticles compared to control subjects and in vitro or in vivo generated microparticles can induce endothelial dysfunction, interfere with coagulation pathways or modulate inflammatory phenomenon. Whether or not these new conveyors of biological information contribute to the acquisition and/or maintenance of the altered endothelial phenotype is unexplored in PH and requires further study.
Schistosoma haematobium Infection and CD4+ T-Cell Levels: A Cross-Sectional Study of Young South African Women

Schistosoma (S.) haematobium causes urogenital schistosomiasis and has been hypothesized to adversely impact HIV transmission and progression. On the other hand it has been hypothesized that HIV could influence the manifestations of schistosomiasis. In this cross-sectional study, we explored the association between urogenital S. haematobium infection and CD4 cell counts in 792 female high-school students from randomly selected schools in rural KwaZulu-Natal, South Africa. We also investigated the association between low CD4 cell counts in HIV positive women and the number of excreted schistosome eggs in urine. Sixteen percent were HIV positive and 31% had signs of urogenital schistosomiasis (as determined by genital sandy patches and / or abnormal blood vessels on ectocervix / vagina by colposcopy or presence of eggs in urine). After stratifying for HIV status, participants with and without urogenital schistosomiasis had similar CD4 cell counts. Furthermore, there was no significant difference in prevalence of urogenital schistosomiasis in HIV positive women with low and high CD4 cell counts. There was no significant difference in the number of eggs excreted in urine when comparing HIV positive and HIV negative women. Our findings indicate that urogenital schistosomiasis do not influence the number of circulating CD4 cells.
Consumptions of plain water, moisture in foods and beverages, and total water in relation to dietary micronutrient intakes and serum nutrient profiles among US adults

Abstract Objective To investigate water contributors in relation to dietary and serum micronutrient profiles. Design A cross-sectional study. The main exposures were water contributors. Selected dietary and serum micronutrient levels were outcome measures. Settings The US population and its subgroups. Subjects US adults (n 2691) aged ≥20 years from the National Health and Nutrition Examination Survey 2005–2006. Results The daily mean total water intake was 3·1 (se 0·047) litres, with 68 % of adults consuming below the Adequate Intake level. Total water intake was higher in adults with higher BMI and physical activity, those taking dietary supplements and alcohol consumers (P < 0·05). Plain water intake was positively associated with food moisture and negatively with beverage moisture (P < 0·001). Beverage moisture was negatively associated with food moisture (P < 0·001). In multivariate regression analyses, plain water and food moisture intakes were positively associated with Fe, Ca, vitamins A, B, C, E and K and carotenoid intakes (P < 0·05). However, beverage moisture was unrelated to Ca, niacin and vitamin B6 intakes, and negatively associated with Fe, vitamin A, folate, vitamins C, E and K and carotenoid intakes (P < 0·05). Concentrations of serum vitamins A and C and carotenoids increased with plain water and food moisture intakes (P < 0·05) but decreased (P < 0·01) or were unrelated to beverage moisture intake. Conclusions Various contributors of total water intake differed in their associations with dietary and serum micronutrient profiles in US adults. The study provides evidence of plain water benefits on micronutrient adequacy over beverages.