Miracle-dz/UniFAR-FTUs huggingface dataset:
Sources and formation mechanisms of carbonaceous aerosol at a regional background site in the Netherlands : Insights from a year-long radiocarbon study

Abstract. We measured the radioactive carbon isotope 14C (radiocarbon) in various fractions of the carbonaceous aerosol sampled between February 2011 and March 2012 at the Cesar Observatory in the Netherlands. Based on the radiocarbon content in total carbon (TC), organic carbon (OC), water-insoluble organic carbon (WIOC), and elemental carbon (EC), we estimated the contribution of major sources to the carbonaceous aerosol. The main source categories were fossil fuel combustion, biomass burning, and other contemporary carbon, which is mainly biogenic secondary organic aerosol material (SOA). A clear seasonal variation is seen in EC from biomass burning (ECbb), with lowest values in summer and highest values in winter, but ECbb is a minor fraction of EC in all seasons. WIOC from contemporary sources is highly correlated with ECbb, indicating that biomass burning is a dominant source of contemporary WIOC. This suggests that most biogenic SOA is water soluble and that water-insoluble carbon stems mainly from primary sources. Seasonal variations in other carbon fractions are less clear and hardly distinguishable from variations related to air mass history. Air masses originating from the ocean sector presumably contain little carbonaceous aerosol from outside the Netherlands, and during these conditions measured carbon concentrations reflect regional sources. In these situations absolute TC concentrations are usually rather low, around 1.5 µg m−3, and ECbb is always very low ( ∼ 0.05 µg m−3), even in winter, indicating that biomass burning is not a strong source of carbonaceous aerosol in the Netherlands. In continental air masses, which usually arrive from the east or south and have spent several days over land, TC concentrations are on average by a factor of 3.5 higher. ECbb increases more strongly than TC to 0.2 µg m−3. Fossil EC and fossil WIOC, which are indicative of primary emissions, show a more moderate increase by a factor of 2.5 on average. An interesting case is fossil water-soluble organic carbon (WSOC, calculated as OC-WIOC), which can be regarded as a proxy for SOA from fossil precursors. Fossil WSOC has low concentrations when regional sources are sampled and increases by more than a factor of 5 in continental air masses. A longer residence time of air masses over land seems to result in increased SOA concentrations from fossil origin.
This Paper Is Included in the Proceedings of the 11th Usenix Symposium on Networked Systems Design and Implementation (nsdi '14). Building Web Applications on Top of Encrypted Data Using Mylar Building Web Applications on Top of Encrypted Data Using Mylar

Web applications rely on servers to store and process confidential information. However, anyone who gains access to the server (e.g., an attacker, a curious administrator, or a government) can obtain all of the data stored there. This paper presents Mylar, a platform for building web applications , which protects data confidentiality against attackers with full access to servers. Mylar stores sensitive data encrypted on the server, and decrypts that data only in users' browsers. Mylar addresses three challenges in making this approach work. First, Mylar allows the server to perform keyword search over encrypted documents, even if the documents are encrypted with different keys. Second, Mylar allows users to share keys and encrypted data securely in the presence of an active adversary. Finally , Mylar ensures that client-side application code is authentic, even if the server is malicious. Results with a prototype of Mylar built on top of the Meteor framework are promising: porting 6 applications required changing just 36 lines of code on average, and the performance overheads are modest, amounting to a 17% throughput loss and a 50 ms latency increase for sending a message in a chat application.
Cross-sectional study of HPV testing in self-sampled urine and comparison with matched vaginal and cervical samples in women attending colposcopy for the management of abnormal cervical screening

Objectives Human papillomavirus (HPV) testing in cervical screening offers the potential for self-sampling to improve uptake among non-attenders. High-risk (HR) HPV detection in urine shows promise, but few studies have examined its sensitivity for cervical intraepithelial neoplasia (CIN2+) detection compared with standard cervical samples. The aims of this cross-sectional study were to optimise conditions for urine testing for HPV detection; to determine concordance for HR-HPV detection in matched urine, vaginal and cervical samples; to compare the sensitivity of HR-HPV testing for the detection of CIN2+ in matched samples; and to determine the acceptability of urine testing for cervical screening. Design Cross-sectional study. Setting Secondary care colposcopy clinic in North West England. Participants Women aged 25 years of age or older, attending colposcopy clinic for management of abnormal cervical screening results or a suspicious-looking cervix. In total, 104 women took part in the study. Triple matched samples were available for 79 and 66 women using Abbott RealTime (ART) and Roche Cobas 4800 (RC), respectively. Intervention Self-collected urine and vaginal samples and practitioner-obtained cervical samples were tested for HR-HPV by ART and RC assays, including comparison of neat and preservative-fixed urine. Colposcopic opinion was recorded and directed cervical biopsies taken if clinically indicated. The acceptability of self-testing was evaluated by questionnaire. Primary outcome measure The sensitivity of urine to detect underlying CIN2+. Secondary outcome measures The comparative sensitivity of vaginal and cervical samples to detect CIN2+; the acceptability of urine sampling. Results Preservative-fixed, but not neat urine, showed good concordance with vaginal samples for the detection of HR-HPV. The sensitivity for detecting CIN2+ was 15/18 (83%) for urine and 16/18 (89%) for cervical and vaginal samples by ART, and 15/17 (88%) for all samples by RC. Urine-based testing was broadly acceptable to women. Conclusions Urinary HR-HPV detection offers an alternative strategy of cervical screening. Larger studies to determine its clinical utility are warranted.
A Markovian approach for modeling packet traffic with long-range dependence

We present a simple Markovian framework for modeling packet traffic with variability over several time scales. We present a fitting procedure for matching second-order properties of counts to that of a second-order self-similar process. Our models essentially consist of superpositions of two-state Markov modulated Poisson processes (MMPPs). We illustrate that a superposition of four two-state MMPPs suffices to model second-order self-similar behavior over several time scales. Our modeling approach allows us to fit to additional descriptors while maintaining the second-order behavior of the counting process. We use this to match interarrival time correlations.
Hypertonic Saline in Acute Bronchiolitis : A Randomized Controlled Trial

BACKGROUND: Research suggests that hypertonic saline (HS) may improve mucous flow in infants with acute bronchiolitis. Data suggest a trend favoring reduced length of hospital stay and improved pulmonary scores with increasing concentration of nebulized solution to 3% and 5% saline as compared with 0.9% saline mixed with epinephrine. To our knowledge, 7% HS has not been previously investigated. METHODS: We conducted a prospective, double-blind, randomized controlled trial in 101 infants presenting with moderate to severe acute bronchiolitis. Subjects received either 7% saline or 0.9% saline, both with epinephrine. Our primary outcome was a change in bronchiolitis severity score (BSS), obtained before and after treatment, and at the time of disposition from the emergency department (ED). Secondary outcomes measured were hospitalization rate, proportion of admitted patients discharged at 23 hours, and ED and inpatient length of stay. RESULTS: At baseline, study groups were similar in demographic and clinical characteristics. The decrease in mean BSS was not statistically significant between groups (2.6 vs 2.4 for HS and control groups, respectively). The difference between the groups in proportion of admitted patients (42% in HS versus 49% in normal saline), ED or inpatient length of stay, and proportion of admitted patients discharged at 23 hours was not statistically significant. CONCLUSIONS: In moderate to severe acute bronchiolitis, inhalation of 7% HS with epinephrine does not appear to confer any clinically significant decrease in BSS when compared with 0.9% saline with epinephrine. Pediatrics 2014;133:e8–e13 AUTHORS: Jonathan D. Jacobs, MD,ab Megan Foster, PharmD, BCPS,c Jim Wan, PhD,d and Jay Pershad, MD, MMMa aDivision of Emergency Medicine, Department of Pediatrics, and Departments of cPharmacy and dPreventive Medicine, Biostatistics and Epidemiology, University of Tennessee Health Science Center, Memphis, Tennessee; and bDivision of Emergency Medicine, Department of Pediatrics, Le Bonheur Children’s Hospital, Memphis, Tennessee
Toll-Like Receptor 4–Myeloid Differentiation Primary Response Gene 88 Pathway Is Involved in the Inflammatory Development of Polymyositis by Mediating Interferon-γ and Interleukin-17A in Humans and Experimental Autoimmune Myositis Mouse Model

Objective Toll-like receptor 4 (TLR4) is one of the key players in the development of many autoimmune diseases. To determine the possible role of TLR4 in polymyositis (PM) development, we collected muscle samples from PM patients and mice subjected to an experimental autoimmune myositis (EAM) model. Methods We measured TLR4–MyD88 pathway-related factors, interferon-γ (IFN-γ), and interleukin-17A (IL-17A) in EAM mice and PM patients. Then, we observed the changes of above factors and the inflammatory development of EAM mice with TLR4 antagonist TAK-242, IFN-γ, or IL-17A antibody treatment. Results The expression of TLR4, MyD88, and NF-κB was significantly upregulated in the muscle tissues both in 22 patients with PM and in the EAM model. As expected, increased levels of various cytokines, such as IL-1β, IL-6, IL-10, IL-12, tumor necrosis factor-α, TGF-β, IFN-γ, and IL-17A, were evident in the serum of EAM mice. Moreover, mRNA expression levels of IFN-γ and IL-17A were significantly increased in both PM patients and EAM mice. Consistently, the levels of these factors were positively correlated with the degree of muscle inflammation in EAM mice. However, when EAM mice were treated with TLR4 antagonist TAK-242, the expression of IFN-γ and IL-17A was decreased. When the cytokines were neutralized by anti-IFN-γ or anti-IL-17A antibody, the inflammatory development of EAM exacerbated or mitigated. Conclusion The present study provided the important evidence that the TLR4–MyD88 pathway may be involved in the immune mechanisms of PM by mediating IFN-γ and IL-17A.
Around the (Virtual) World: Infinite Walking in Virtual Reality Using Electrical Muscle Stimulation

Virtual worlds are infinite environments in which the user can move around freely. When shifting from controller-based movement to regular walking as an input, the limitation of the real world also limits the virtual world. Tackling this challenge, we propose the use of electrical muscle stimulation to limit the necessary real-world space to create an unlimited walking experience. We thereby actuate the users` legs in a way that they deviate from their straight route and thus, walk in circles in the real world while still walking straight in the virtual world. We report on a study comparing this approach to vision shift - the state of the art approach - as well as combining both approaches. The results show that particularly combining both approaches yield high potential to create an infinite walking experience.
Disease outcome of inflammatory bowel disease patients: General outline of a Europe-wide population-based 10-year clinical follow-up study

Objective. To give a general outline of a 10-year clinical follow-up study of a population-based European cohort of inflammatory bowel disease (IBD) patients and to present the first results in terms of clinical outcome parameters and risk factors. Materials and methods. A population-based cohort of newly, prospectively, diagnosed cases was initiated between 1991 and 1993. The 2201 patients with IBD (706 had Crohn's disease (CD), 1379 had ulcerative colitis (UC) and 116 had indeterminate colitis) originated from 20 different areas in 11 different European countries and Israel. For the 10-year follow-up of this cohort, electronic data-collecting instruments were made available through an Internet-based website. Data concerning vital status, disease activity, medication use, surgical events, cancer, pregnancy, fertility, quality of life and health-care costs were gathered. A blood sample was obtained from patients and controls to perform genotypic characterization. Results. Thirteen centres from eight European countries and Israel participated. In 958 (316 CD and 642 UC) out of a total of 1505 IBD patients (64%) from these 13 centres, a complete dataset was obtained at follow-up. Even though an increased mortality risk was observed in CD patients 10 years after diagnosis, a benign disease course was observed in this patient group in terms of disease recurrence. A correlation between ASCA and CARD15 variants in CD patients and complicated disease course was observed. A north–south gradient was observed regarding colectomy rates in UC patients. Direct costs were found to be highest in the first year after diagnosis and greater in CD patients than in UC patients, with marked differences between participating countries. Conclusions. This 10-year clinical follow-up study of a population-based European cohort of IBD patients provides updated information on disease outcome of these patient groups.
Peer-Based Quality Assurance in Information Systems Development: A Transactive Memory Perspective

This study provides a better understanding of how the application of collaborative software development techniques is shaped by and shapes the transactive memory systems of information systems development teams. In particular, we draw from results of critical realist case studies on development teams that apply pair programming and peer code review. The findings improve our understanding of how teams vary in the way they apply these collaborative quality assurance techniques and how their application is theoretically linked to a team’s transactive memory system, as well as the properties of the technologies the techniques rely on. This study replies to recent calls to study socio-cognitive implications of software development techniques. It contributes to previous work on quality assurance techniques by being among the first to empirically study effects that go beyond error correction. This also adds substance to the discussion if different techniques complement or substitute each other.
Challenges in implementing the 2015 BASHH guidelines for the appropriate use of post-exposure prophylaxis for HIV following sexual exposure

The use of post exposure prophylaxis for human immunodeficiency virus (HIV) following sexual exposure (PEPSE) was retrospectively audited in an inner city genitourinary clinic against the 2015 national guidelines by the British Association for Sexual Health and HIV (BASHH). One-hundred out of a total of 101 patients (99%) had a baseline HIV test done. 82.1% (n=83) of patients were given PEPSE prescriptions fitting within recommended indications lower than the 90% target set by BASHH. 84.2% (n=85) of patients had PEPSE administered within 72 hours lower than the 90%. 61.4% (n=62) of patients were known to have completed four weeks of PEPSE lower than the 75% target. 61.4% (n=62) of patients were screened for sexually transmitted infections (STIs) lower than the 90% target. 59.4% (n=60%) of patients had post-PEPSE HIV bloods slightly lower than the 60% target.
THE 0.3–30 keV SPECTRA OF POWERFUL STARBURST GALAXIES: NuSTAR AND CHANDRA OBSERVATIONS OF NGC 3256 AND NGC 3310

We present nearly simultaneous Chandra and NuSTAR observations of two actively star-forming galaxies within 50 Mpc: NGC 3256 and NGC 3310. Both galaxies are significantly detected by both Chandra and NuSTAR, which together provide the first-ever spectra of these two galaxies spanning 0.3–30 keV. The X-ray emission from both galaxies is spatially resolved by Chandra; we find that hot gas dominates the E < 1–3 keV emission while ultraluminous X-ray sources (ULXs) provide majority contributions to the emission at E > 1–3 keV. The NuSTAR galaxy-wide spectra of both galaxies follow steep power-law distributions with Γ ≈ 2.6 at E > 5–7 keV. Using new and archival Chandra data, we search for signatures of heavily obscured or low luminosity active galactic nuclei (AGNs). We find that both NGC 3256 and NGC 3310 have X-ray detected sources coincident with nuclear regions; however, the steep NuSTAR spectra of both galaxies restricts these sources to be either low luminosity AGNs (L2−10 keV/LEdd ≲ 10−5) or non-AGNs in nature (e.g., ULXs or crowded X-ray sources that reach L2−10 keV ∼ 1040 erg s−1 cannot be ruled out). Combining our constraints on the 0.3–30 keV spectra of NGC 3256 and NGC 3310 with equivalent measurements for nearby star-forming galaxies M83 and NGC 253, we analyze the star formation rate (SFR) normalized spectra of these starburst galaxies. The spectra of all four galaxies show sharply declining power-law slopes at energies above 3–6 keV primarily due to ULX populations. Our observations therefore constrain the average spectral shape of galaxy-wide populations of luminous accreting binaries (i.e., ULXs). Interestingly, despite a completely different galaxy sample selection, emphasizing here a range of SFRs and stellar masses, these properties are similar to those of super-Eddington accreting ULXs that have been studied individually in a targeted NuSTAR ULX program. We also find that NGC 3310 exhibits a factor of ≈3–10 elevation of X-ray emission over the other star-forming galaxies due to a corresponding overabundance of ULXs. We argue that the excess of ULXs in NGC 3310 is most likely explained by the relatively low metallicity of the young stellar population in this galaxy, a property that is expected to produce an excess of luminous X-ray binaries for a given SFR.
Enhanced Low Oxygen Survival in Arabidopsis through Increased Metabolic Flux in the Fermentative Pathway1

We manipulated the enzyme activity levels of the alcohol fermentation pathway, pyruvate decarboxylase (PDC), and alcohol dehydrogenase (ADH) in Arabidopsis using sense and antisense overexpression of the corresponding genes (PDC1, PDC2, and ADH1). Transgenic plants were analyzed for levels of fermentation and evaluated for changes in hypoxic survival. Overexpression of either Arabidopsis PDC1 or PDC2 resulted in improved plant survival. In contrast, overexpression of Arabidopsis ADH1 had no effect on flooding survival. These results support the role of PDC as the control step in ethanol fermentation. Although ADH1 null mutants had decreased hypoxic survival, attempts to reduce the level of PDC activity enough to see an effect on plant survival met with limited success. The combination of flooding survival data and metabolite analysis allows identification of critical metabolic flux points. This information can be used to design transgenic strategies to improve hypoxic tolerance in plants.
Convex Rank Tests and Semigraphoids

Convex rank tests are partitions of the symmetric group which have desirable geometric properties. The statistical tests defined by such partitions involve counting all permutations in the equivalence classes. Each class consists of the linear extensions of a partially ordered set specified by data. Our methods refine existing rank tests of nonparametric statistics, such as the sign test and the runs test, and are useful for exploratory analysis of ordinal data. We establish a bijection between convex rank tests and probabilistic conditional independence structures known as semigraphoids. The subclass of submodular rank tests is derived from faces of the cone of submodular functions or from Minkowski summands of the permutohedron. We enumerate all small instances of such rank tests. Of particular interest are graphical tests, which correspond to both graphical models and to graph associahedra.
Systematic studies of short bunch-length bursting at ANKA

At ANKA, the Karlsruhe synchrotron radiation source, the so called short bunch-length operation mode allows the reduction of the bunch length down to a few picoseconds. The micro-bunching instability resulting from the high degree of longitudinal compression leads to fluctuations in the emitted intensity in the THz regime, referred to as bursting. For extremely compressed bunches at ANKA bursting also occurs, in a certain current range, below the main bursting threshold. This contribution shows measurements of this short bunch-length bursting and makes first comparisons with theory.
Differential patterns of hybridization and introgression between the swallowtails Papilio machaon and P. hospiton from Sardinia and Corsica islands (Lepidoptera, Papilionidae)

Proportions of hybridization and introgression between the swallowtails Papilio hospiton, endemic to Sardinia and Corsica, and the holarctic Papilio machaon, were characterized using nine fully diagnostic and two differentiated allozyme loci and a mitochondrial DNA marker. Very low frequencies of F1 hybrids were detected in both Sardinia (0–4%, average 1.4%) and Corsica (0–3%, average 0.5%), as well as of first generation backcrosses (B1). No F2 were observed, in agreement with the hybrid breakdown detected in laboratory crosses. In spite of this minimal current gene exchange, specimens carrying introgressed alleles were found in high proportions in P. machaon but in lower proportions in P. hospiton. Introgression apparently occurred through past hybridization and repeated backcrossing, as evidenced by hybrid index scores and Bayesian assignment tests. Levels of introgression were low (0–1%) at two sex‐linked loci and mitochondrial DNA, limited (0.4–2%) at three autosomal loci coding for dimeric enzymes, and high (up to 43%) at four autosomal loci coding for monomeric enzymes. Accordingly, selective filters are acting against foreign alleles, with differential effectiveness depending on the loci involved. The low levels of introgression at sex‐linked loci and mitochondrial DNA are in agreement with Haldane's rule and suggest that introgression in P. machaon proceeds mainly through males, owing to a lower fitness of hybrid females. Papilio machaon populations showed higher levels of introgression in Sardinia than in Corsica. The role of reinforcement in the present reproductive isolation between P. machaon and P. hospiton is examined, as well as the evolutionary effects of introgressive hybridization between the two species.