Miracle-dz/UniFAR-FTUs huggingface dataset:
Transmembrane helices in “classical” nuclear reproductive steroid receptors: a perspective

Steroid receptors of the nuclear receptor superfamily are proposed to be either: 1) located in the cytosol and moved to the cell nucleus upon activation, 2) tethered to the inside of the plasma membrane, or 3) retained in the nucleus until free steroid hormone enters and activates specific receptors. Using computational methods to analyze peptide receptor topology, we find that the “classical” nuclear receptors for progesterone (PRB/PGR), androgen (ARB/AR) and estrogen (ER1/ESR1) contain two transmembrane helices (TMH) within their ligand-binding domains (LBD). The MEMSAT-SVM algorithm indicates that ARB and ER2 (but not PRB or ER1) contain a pore-lining (channel-forming) region which may merge with other pore-lining regions to form a membrane channel. ER2 lacks a TMH, but contains a single pore-lining region. The MemBrain algorithm predicts that PRB, ARB and ER1 each contain one TMH plus a half TMH separated by 51 amino acids. ER2 contains two half helices. The TM-2 helices of ARB, ER1 and ER2 each contain 9–13 amino acid motifs reported to translocate the receptor to the plasma membrane, as well as cysteine palmitoylation sites. PoreWalker analysis of X-ray crystallographic data identifies a pore or channel within the LBDs of ARB and ER1 and predicts that 70 and 72 residues are pore-lining residues, respectively. The data suggest that (except for ER2), cytosolic receptors become anchored to the plasma membrane following synthesis. Half-helices and pore-lining regions in turn form functional ion channels and/or facilitate passive steroid uptake into the cell. In perspective, steroid-dependent insertion of “classical” receptors containing pore-lining regions into the plasma membrane may regulate permeability to ions such as Ca2+, Na+ or K+, as well as facilitate steroid translocation into the nucleus.
A model of Titan ’ s haze of fractal aerosols constrained by multiple observations

We use Titan’s geometric albedo to constrain the vertical distribution of the haze. Microphysical models incorporating fractal aggregates do not readily 3t the methane features at 0:62 m band and the dark 0:88 m of the albedo spectrum simultaneously. We take advantage of this apparent discrepancy to constrain the haze vertical pro3le. We used the geometric albedo and several results and constraints from other works to better constrain the vertical haze extinction pro3le, especially in the low stratosphere. The objective of this model is to give a solution that simultaneously 3ts the main constraints known to apply to the haze. We 3nd that the haze extinction increases with decreasing altitude with a scale height about equal to the atmospheric scale height down to 100 km. Below this altitude, extinction must decrease down to 30 km. This is necessary in order to have enough haze to sustain a relatively high albedo (0.076) in the dark 0:88 m methane band and to show the 0:62 m band in the haze continuum. We set the haze production rate around 7× 10−14 kg m−2 s−1, and the aerosols production altitude around 400 km (or at pressure 1:5 Pa). The physical processes which generate such a pro3le are not clear. However, purely one-dimensional e=ects such as condensation, sedimentation, and rainout can be ruled out, and we believe that this relative clearing in Titan’s troposphere and lower stratosphere is due to particle horizontal transport by the mean circulation. 2003 Elsevier Ltd. All rights reserved.
Road Killed Carnivores Illustrate the Status of Zoonotic Helminthes in Caspian Sea Littoral of Iran

Background: Carnivore carcasses on the roads can be regarded as study materials in parasitology and eco-epidemiology. Stray carnivores such as dogs and cats are known to harbor so many different pathogens like zoonotic helminthes. The current investigation, apparent the status of the helminthic parasites found in road killed carnivores from different parts of Guilan Province north of Iran. Methods: Fifty road killed carnivores including 27 stray dogs (Canis familiaris), 11 golden jackals (Canis aureus) and 12 stray cats (Felis catus) were collected from 21 locations of Guilan Province, during Apr to Nov 2015. Internal organs of the carcasses, including digestive tract, heart, kidneys, lungs, liver, skin, eyes as well as muscles were carefully inspected and sampled for helminthological investigation. Results: About 80% of the 50 carnivores, (stray dogs 77.77%, golden jackals 81.81%, and stray cats 91.66%) were found naturally infected with helminthic parasites. Dipylidum caninum, Toxocara cati, Toxocara canis, Toxascaris leonine, Ancylostoma caninum, Ancylostoma tubaeforme, Dirofilaria immitis, Dioctophyma renale, Dipylidum caninum, Echinococcus granulosus, Mesocestoides spp. , Taenia hydatigena, Taenia hydatigera, Joyuxiella spp. , Spirometra spp. are reported herein. Conclusion: The prevalent occurrence of zoonotic helminthes such as T. canis, T. cati, T. leonina, E. granulosus, D. immitis and D. renale in stray carnivores should be considered as a public health hazard, specifically within a vast tourism area like Guilan Province.
Gene Structures, Evolution and Transcriptional Profiling of the WRKY Gene Family in Castor Bean (Ricinus communis L.)

WRKY proteins comprise one of the largest transcription factor families in plants and form key regulators of many plant processes. This study presents the characterization of 58 WRKY genes from the castor bean (Ricinus communis L., Euphorbiaceae) genome. Compared with the automatic genome annotation, one more WRKY-encoding locus was identified and 20 out of the 57 predicted gene models were manually corrected. All RcWRKY genes were shown to contain at least one intron in their coding sequences. According to the structural features of the present WRKY domains, the identified RcWRKY genes were assigned to three previously defined groups (I–III). Although castor bean underwent no recent whole-genome duplication event like physic nut (Jatropha curcas L., Euphorbiaceae), comparative genomics analysis indicated that one gene loss, one intron loss and one recent proximal duplication occurred in the RcWRKY gene family. The expression of all 58 RcWRKY genes was supported by ESTs and/or RNA sequencing reads derived from roots, leaves, flowers, seeds and endosperms. Further global expression profiles with RNA sequencing data revealed diverse expression patterns among various tissues. Results obtained from this study not only provide valuable information for future functional analysis and utilization of the castor bean WRKY genes, but also provide a useful reference to investigate the gene family expansion and evolution in Euphorbiaceus plants.
The Role of Movement in Face Recognition

The movement of the face may provide information that facilitates recognition. However, in mostsituations people who are very familiar to us can be recognized easily from a single typical view of the face and the presence of further information derived from movement would not be expected to improve performance. Here the effects of movement on face recognition are investigated for faces presented under non-optimal conditions. Subjects were required to identify moving or still videotaped faces of famous and unknown people. Faces were presented in negative, a manipulation which preserved the two-dimensional shape and configuration of the face and facial features, while degrading face recognition performance. Results indicated that moving faces were significantly better recognized than still faces. It was proposed that movement may provide evidence about the three-dimensional structure of the face and allow the recognition of characteristic facial gestures. When the faces were inverted, no significant effect .
Phase-noise reduction in surface wave oscillators by using nonlinear sustaining amplifiers

Nonlinear sustaining amplifier operation has been investigated and applied to high-power negative resistance oscillators (NRO), using single-port surface transverse wave (STW) resonators, and single-transistor sustaining amplifiers for feedback-loop STW oscillators (FLSO) stabilized with two-port STW devices. In all cases, self-limiting, silicon (Si)-bipolar sustaining amplifiers that operate in the highly nonlinear AB-, B-, or C-class modes are implemented. Phase-noise reduction is based on the assumption that a sustaining amplifier, operating in one of these modes, uses current limiting and remains cut off over a significant portion of the wave period. Therefore, it does not generate 1/f noise over the cut-off portion of the radio frequency (R-F) cycle, and this reduces the close-in oscillator phase noise significantly. The proposed method has been found to provide phase-noise levels in the -111 to -119 dBc/Hz range at 1 KHz carrier offset in 915 MHz C-class power NRO and FLSO generating up to 23 dBm of RF-power at RF versus dc (RF/dc) efficiencies exceeding 40%. C-class amplifier design techniques are used for adequate matching and high RF/dc efficiency.
Lack of Adherence to Practice Guidelines for Women With Atypical Glandular Cells on Cervical Cytology

OBJECTIVE: We sought to estimate the rates and types of evaluation in women with atypical glandular cells of undetermined significance (AGC-US) on cervical cytology and to assess these findings on the basis of published management guidelines. METHODS: The rates of histologic sampling, comprehensive initial evaluations, and secondary evaluations were assessed in 477 women with an AGC-US Pap test from 1998 to 2001. A comprehensive evaluation was defined as a colposcopy and an endocervical curettage with or without a cervical biopsy. For women aged 35 or older, a comprehensive evaluation also included an endometrial biopsy. A secondary evaluation consisted of a diagnostic cone biopsy. RESULTS: Sixty-four percent of women with an AGC-US Pap test had histologic sampling; 36% were followed by repeat Pap test only. Thirty-six percent of women with an AGC-US Pap test had a comprehensive evaluation. Women with an AGC-US Pap test that was subclassified as malignant-appearing had higher rates of histologic and comprehensive evaluations than women with a benign-appearing or unspecified AGC-US Pap test (P < .01). Twenty-eight percent of women aged 35 or older had comprehensive evaluations compared with 57% of women younger than the age of 35 (P < .01). Secondary evaluations were performed in 8% of women with persistent AGC-US Pap tests and 2% of women with malignant-appearing AGC-US Pap tests after negative initial histologic evaluations. Twelve of the 42 cases of disease (29%) were diagnosed more than 1 year from the initial AGC-US Pap test. CONCLUSION: On the basis of accepted management guidelines, these data suggest that women with AGC-US Pap tests are undermanaged in both their initial and secondary evaluations. LEVEL OF EVIDENCE: III
WISC-R Verbal and Performance Abilities of Native American Students Referred for School Learning Problems.

This study was designed to determine if three diagnostic groups of Navajo children differed on intellectual dimensions as measured by the WISC-R. Subjects had been previously diagnosed by state certified professionals and were identified as nonhan dicapped (NH) (N = 113), educationally disadvantaged. (ED) (N = 189), and learning disabled (LD) (N = 150). NH group means on all WISC-R variables were significantly higher than the LD group means. The ED and the LD group means were similar on the verbal measures, but the LD group scores were lower than the ED group scores on performance measures. The NH group demonstrated intellectual abilities and deficits similar to those reported for other primary-grade Navajo children who had not been referred for suspected handicapping conditions.
Psychological distress among Chinese immigrants to the USA

Migration is a major life event that alters the functioning of individuals, often leading to the disruption of families and other social networks. When adaptation and coping fail, psychological distress may result. The purpose of this study is to examine the prevalence of psychological distress and to identify risk factors associated with the development of psychological distress symptoms in Chinese immigrants. A cross-sectional survey was conducted in a Chinese community in Maryland, USA. A total of 247 people completed the survey. Descriptive statistics were used to describe demographic and prevalence data. Differences in means of psychological distress scores by group were examined with t-tests and analysis of variance. Multiple regression analysis was used to test multiple predictors of psychological distress scores. The prevalence of psychological distress among Chinese immigrants in this study was 22.3%, double the expected frequency in the general US population. Being younger, self-reported with poor health and financial strain predicted the development of psychological distress. The relatively high prevalence of psychological distress in adult Chinese immigrants has important implications for healthcare professionals in the area of cross-cultural mental health. Recommendations center on routine screening for psychological distress and building capacity for culturally sensitive interventions.
Simulation of Forces between Humid Amorphous Silica Surfaces: A Comparison of Empirical Atomistic Force Fields

Atmospheric humidity strongly influences the interactions between dry granular particles in process containers. To reduce the energy loss in industrial production processes caused by particle agglomeration, a basic understanding of the dependence of particle interactions on humidity is necessary. Hence, in this study, molecular dynamic simulations were carried out to calculate the adhesion between silica surfaces in the presence of adsorbed water. For a realistic description, the choice of force field is crucial. Because of their frequent use and transferability to biochemical systems, the Clay and CWCA force fields were investigated with respect to their ability to describe the water–silica interface in comparison to the more advanced Reax force field, ab initio calculations, and experiments.
An analysis of the concept of organizational commitment.

TOPIC Building organizational commitment. PURPOSE This paper aims to analyze the concept of organizational commitment, including its attributes, antecedents, outcomes, and measurements. SOURCES OF INFORMATION CINAHL, MEDLINE, Psychology and Behavioral Sciences Collection, Sociological Collection, and PubMed. CONCLUSION By understanding the concept of organizational commitment, administrators and nurses can become more aware of their levels of commitment, bridge gaps in communication, and eventually provide higher-quality care to clients.
Estimation of the Burden of Pandemic(H1N1)2009 in Developing Countries: Experience from a Tertiary Care Center in South India

Background The burden of the pandemic (H1N1) 2009 influenza might be underestimated if detection of the virus is mandated to diagnose infection. Using an alternate approach, we propose that a much higher pandemic burden was experienced in our institution. Methodology/Principal Findings Consecutive patients (n = 2588) presenting to our hospital with influenza like illness (ILI) or severe acute respiratory infection (SARI) during a 1-year period (May 2009–April 2010) were prospectively recruited and tested for influenza A by real-time RT-PCR. Analysis of weekly trends showed an 11-fold increase in patients presenting with ILI/SARI during the peak pandemic period when compared with the pre-pandemic period and a significant (P<0.001) increase in SARI admissions during the pandemic period (30±15.9 admissions/week) when compared with pre-pandemic (7±2.5) and post-pandemic periods (5±3.8). However, Influenza A was detected in less than one-third of patients with ILI/SARI [699 (27.0%)]; a majority of these (557/699, 79.7%) were Pandemic (H1N1)2009 virus [A/H1N1/09]. An A/H1N1/09 positive test was correlated with shorter symptom duration prior to presentation (p = 0.03). More ILI cases tested positive for A/H1N1/09 when compared with SARI (27.4% vs. 14.6%, P = 0.037). When the entire study population was considered, A/H1N1/09 positivity was associated with lower risk of hospitalization (p<0.0001) and ICU admission (p = 0.013) suggesting mild self-limiting illness in a majority. Conclusion/Significance Analysis of weekly trends of ILI/SARI suggest a higher burden of the pandemic attributable to A/H1N1/09 than estimates assessed by a positive PCR test alone. The study highlights methodological consideration in the estimation of burden of pandemic influenza in developing countries using hospital-based data that may help assess the impact of future outbreaks of respiratory illnesses.
The Importance of Perceptions in Restorative Justice Conferences: The Influence of Offender Personality Traits on Procedural Justice and Shaming

Research suggests that restorative justice (RJ) conferences are more just than traditional court processing due to the presence of procedural justice (PJ). These conferences also promote reintegrative shaming which, in contrast to disintegrative shaming, allows offenders to repair their ties with the community. Yet, fairness and the type of shaming experienced may depend on perceptions of the offender. We argue that the personality traits of negative emotionality and low constraint influence offenders' evaluations of the fairness of these conferences, which have implications for their experience of shaming. We test these arguments using data from a sample of 498 offenders involved in the Australian Reintegrative Shaming Experiments. Results reveal that personality traits affect perceptions of PJ and both types of shaming, and that PJ mediates these effects. The findings support the notion that RJ conferences are perceived to be procedurally just and reintegrative for certain types of offenders.
Upper Airway Control and Function : Implications for Sleep-Disordered Breathing Arousal from sleep : implications for obstructive sleep apnea pathogenesis and treatment

Eckert DJ, Younes MK. Arousal from sleep: implications for obstructive sleep apnea pathogenesis and treatment. J Appl Physiol 116: 302–313, 2014. First published August 29, 2013; doi:10.1152/japplphysiol.00649. 2013. —Historically, brief awakenings from sleep (cortical arousals) have been assumed to be vitally important in restoring airflow and blood-gas disturbances at the end of obstructive sleep apnea (OSA) breathing events. Indeed, in patients with blunted chemical drive (e.g., obesity hypoventilation syndrome) and in instances when other defensive mechanisms fail, cortical arousal likely serves an important protective role. However, recent insight into the pathogenesis of OSA indicates that a substantial proportion of respiratory events do not terminate with a cortical arousal from sleep. In many cases, cortical arousals may actually perpetuate blood-gas disturbances, breathing instability, and subsequent upper airway closure during sleep. This brief review summarizes the current understanding of the mechanisms mediating respiratory-induced cortical arousal, the physiological factors that influence the propensity for cortical arousal, and the potential dual roles that cortical arousal may play in OSA pathogenesis. Finally, the extent to which existing sedative agents decrease the propensity for cortical arousal and their potential to be therapeutically beneficial for certain OSA patients are highlighted.
Impact of a nurse-led clinic for chronic constipation in children

The impact of a nurse-led constipation clinic was assessed by evaluating the first 50 patients, aged 1.5 to 10 years, using a questionnaire before initial clinic visit and at the third clinic visit, three to four months later. Patients had been constipated for at least six months. The nurses explained the physiology of constipation, the rationale for laxative treatment and the need to comply with treatment. Good toileting behaviour was encouraged. This resulted in an increase in defaecation frequency and stool softness, whereas soiling and pain on defaecation decreased. There was no significant change in the amount of laxatives taken, although it was suspected that compliance improved. Parental understanding of constipation and its management increased. Overall, the control of constipation in children improved markedly through attendance at a nurse-led clinic.
Cytotoxic T‐cell‐mediated defense against infections in human liver transplant recipients

Previous studies have shown that postoperative infection is highest in transplant recipients with preexisting high levels of cytotoxic T lymphocytes (CTLs). To study this phenomenon, 106 adult liver transplant recipients were divided into 3 groups, based on hierarchical clustering of the CD3+CD8+CD45 isoform fractions prior to living donor liver transplantation (LDLT). Group I had the highest naive T‐cell levels (subset CD45RO−CCR7+), Group II had the highest effector/memory (EM) T‐cell levels (subset CD45RO+CCR7−), and Group III had the highest effector T‐cell levels (subset CD45RO−CCR7−). In Group I, CTLs upregulated in response to invading pathogens much earlier and more rapidly than the other groups; this response was associated with CD4+ T‐cell help, downregulation of CD27+CD28+ subsets, and upregulation of interferon‐gamma and perforin expression. In contrast, in Groups II and III, CTLs upregulated slowly following persistent viral infection and did not respond efficiently to acute infection. In addition, Group II's cytolytic responses were due mainly to upregulation of the CD8+ EM T‐cell fraction, whereas Group III's cytolytic responses were attributable to upregulation of effector T cells. The prevalence of EM or effector T cells was dependent on differentiation of the CD8+ phenotype before LDLT. In conclusion, in most infected transplant recipients who died, generation of CD8+ CTLs had been suppressed without associated CD4+ T‐cell help. Liver Transpl 13:287–293, 2007. © 2007 AASLD.
Expectancy-value and cognitive process outcomes in mathematics learning: a structural equation analysis

Existing research has yielded evidence to indicate that the expectancy-value theoretical model predicts students' learning in various achievement contexts. Achievement values and self-efficacy expectations, for example, have been found to exert positive effects on cognitive process and academic achievement outcomes. We tested a conceptual model that depicted the interrelations between the non-cognitive (task value, self-efficacy) and cognitive (deep-learning approach, reflective-thinking) processes of learning, and academic achievement outcomes in mathematics. University students (n = 289) were administered a number of Likert-scale inventories and LISREL 8.80 was used to test various a priori and a posteriori models. Structural equation modeling yielded some important findings: (1) the positive temporally displaced effects of prior academic achievement, self-efficacy expectations and task value on achievement in mathematics, (2) the positive relations between self-efficacy expectations and task values and cognitive process outcomes and (3) the possible mediating role of self-efficacy expectations and task value between prior academic achievement and deep learning, reflective-thinking practice and academic achievement. Overall, our research investigation has provided empirical groundings for further advancement into this area of students' learning.