Miracle-dz/UniFAR-FTUs huggingface dataset:
Memory for Self-Performed Actions in Individuals with Asperger Syndrome

Memory for action is enhanced if individuals are allowed to perform the corresponding movements, compared to when they simply listen to them (enactment effect). Previous studies have shown that individuals with Autism Spectrum Disorders (ASD) have difficulties with processes involving the self, such as autobiographical memories and self performed actions. The present study aimed at assessing memory for action in Asperger Syndrome (AS). We investigated whether adults with AS would benefit from the enactment effect when recalling a list of previously performed items vs. items that were only visually and verbally experienced through three experimental tasks (Free Recall, Old/New Recognition and Source Memory). The results showed that while performance on Recognition and Source Memory tasks was preserved in individuals with AS, the enactment effect for self-performed actions was not consistently present, as revealed by the lower number of performed actions being recalled on the Free Recall test, as compared to adults with typical development. Subtle difficulties in encoding specific motor and proprioceptive signals during action execution in individuals with AS might affect retrieval of relevant personal episodic information. These disturbances might be associated to an impaired action monitoring system.
Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal‐infantile seizures

Purpose: Mutations in SCN2A, the gene encoding the brain voltage‐gated sodium channel α‐subunit Na V 1.2, are associated with inherited epilepsies including benign familial neonatal‐infantile seizures (BFNIS). Functional characterization of three BFNIS mutations was performed to identify defects in channel function that underlie this disease.
Has the free maternal health policy eliminated out of pocket payments for maternal health services? Views of women, health providers and insurance managers in Northern Ghana

Introduction The free maternal health policy was implemented in Ghana in 2008 under the National Health Insurance Scheme (NHIS). The policy sought to eliminate out of pocket (OOP) payments and enhance the utilisation of maternal health services. It is unclear whether the policy had altered OOP payments for services. The study explored views on costs and actual OOP payments during pregnancy. The source of funding for payments was also explored. Methods A convergent parallel mixed methods design, involving quantitative and qualitative data collection approaches. The study was set in the Kassena-Nankana municipality, a rural area in Ghana. Women (n = 406) who utilised services during pregnancy were surveyed. Also, 10 focus groups discussions (FGDs) were held with women who used services during pregnancy as well as 28 in-depth interviews (IDIs) with midwives/nurses (n = 25) and insurance managers/directors (n = 3). The survey was analysed using descriptive statistics, focussing on costs from the women’s perspective. Qualitative data were audio recorded, transcribed and translated verbatim into English where necessary. The transcripts were read and coded into themes and sub-themes. Results The NHIS did not cover all expenses in relation to maternal health services. The overall mean for OOP cost during pregnancy was GH¢17.50 (US$8.60). Both FGDs and IDIs showed that women especially paid for drugs and ultrasound scan services. Sixty-five percent of the women used savings, whilst twenty-two percent sold assets to meet the OOP cost. Some women were unable to afford payments due to poverty and had to forgo treatment. Participants called for payments to be eliminated and for the NHIS to absorb the cost of emergency referrals. All participants admitted the benefits of the policy. Conclusion Women needed to make payments despite the policy. Measures should be put in place to eliminate payments to enable all women to receive services and promote universal health coverage.
Genetic Diversity and Population Structure of F3:6 Nebraska Winter Wheat Genotypes Using Genotyping-By-Sequencing

The availability of information on the genetic diversity and population structure in wheat (Triticum aestivum L.) breeding lines will help wheat breeders to better use their genetic resources and manage genetic variation in their breeding program. The recent advances in sequencing technology provide the opportunity to identify tens or hundreds of thousands of single nucleotide polymorphism (SNPs) in large genome species (e.g., wheat). These SNPs can be utilized for understanding genetic diversity and performing genome wide association studies (GWAS) for complex traits. In this study, the genetic diversity and population structure were investigated in a set of 230 genotypes (F3:6) derived from various crosses as a prerequisite for GWAS and genomic selection. Genotyping-by-sequencing provided 25,566 high-quality SNPs. The polymorphism information content (PIC) across chromosomes ranged from 0.09 to 0.37 with an average of 0.23. The distribution of SNPs markers on the 21 chromosomes ranged from 319 on chromosome 3D to 2,370 on chromosome 3B. The analysis of population structure revealed three subpopulations (G1, G2, and G3). Analysis of molecular variance identified 8% variance among and 92% within subpopulations. Of the three subpopulations, G2 had the highest level of genetic diversity based on three genetic diversity indices: Shannon’s information index (I) = 0.494, diversity index (h) = 0.328 and unbiased diversity index (uh) = 0.331, while G3 had lowest level of genetic diversity (I = 0.348, h = 0.226 and uh = 0.236). This high genetic diversity identified among the subpopulations can be used to develop new wheat cultivars.
Prediction of sudden and non-sudden cardiac death in post-infarction patients with reduced left ventricular ejection fraction by periodic repolarization dynamics: MADIT-II substudy

Abstract Aims To test the value of Periodic Repolarization Dynamics (PRD), a recently validated electrocardiographic marker of sympathetic activity, as a novel approach to predict sudden cardiac death (SCD) and non-sudden cardiac death (N-SCD) and to improve identification of patients that profit from ICD-implantation. Methods and results We included 856 post-infarction patients with left-ventricular ejection fraction (LVEF) ≤30% of the MADIT-II trial in sinus rhythm. Of these, 507 and 348 patients were randomized to ICD or conventional treatment. PRD was assessed from multipolar 10-min baseline ECGs. Primary and secondary endpoints were total mortality, SCD and N-SCD. Multivariable analyses included treatment group, QRS-duration, New York Heart Association classification, blood-urea nitrogen, diabetes mellitus, beta-blocker therapy and LVEF. During follow-up of 20.4 months, 119 patients died (53 SCD and 36 N-SCD). On multivariable analyses, increased PRD was a significant predictor of mortality (standardized coefficient 1.37[1.19–1.59]; P < 0.001) and SCD (1.40 [1.13–1.75]; P = 0.003) but also predicted N-SCD (1.41[1.10–1.81]; P = 0.006). While increased PRD predicted SCD in conventionally treated patients (1.61[1.23–2.11]; P < 0.001), it was predictive of N-SCD (1.63[1.28–2.09]; P < 0.001) and adequate ICD-therapies (1.20[1.03–1.39]; P = 0.017) in ICD-treated patients. ICD-treatment substantially reduced mortality in the lowest three PRD-quartiles by 53% (P = 0.001). However, there was no effect in the highest PRD-quartile (mortality increase by 29%; P = 0.412; P < 0.001 for difference) as the reduction of SCD was compensated by an increase of N-SCD. Conclusion In post-infarction patients with impaired LVEF, PRD is a significant predictor of SCD and N-SCD. Assessment of PRD is a promising tool to identify post-MI patients with reduced LVEF who might benefit from intensified treatment.
Force-Field Compensation in a Manual Tracking Task

This study addresses force/movement control in a dynamic “hybrid” task: the master sub-task is continuous manual tracking of a target moving along an eight-shaped Lissajous figure, with the tracking error as the primary performance index; the slave sub-task is compensation of a disturbing curl viscous field, compatibly with the primary performance index. The two sub-tasks are correlated because the lateral force the subject must exert on the eight-shape must be proportional to the longitudinal movement speed in order to perform a good tracking. The results confirm that visuo-manual tracking is characterized by an intermittent control mechanism, in agreement with previous work; the novel finding is that the overall control patterns are not altered by the presence of a large deviating force field, if compared with the undisturbed condition. It is also found that the control of interaction-forces is achieved by a combination of arm stiffness properties and direct force control, as suggested by the systematic lateral deviation of the trajectories from the nominal path and the comparison between perturbed trials and catch trials. The coordination of the two sub-tasks is quickly learnt after the activation of the deviating force field and is achieved by a combination of force and the stiffness components (about 80% vs. 20%), which is a function of the implicit accuracy of the tracking task.
Effect of moisture content on some engineering properties of peanut varieties

The moisture dependent engineering properties of peanuts are important to design postharvest equipment of the product. In this study some engineering properties of kernels of four peanut varieties, Goli, Valencia, Iraqi 1 and Iraqi 2, were evaluated as a function of moisture content. Results showed that with increasing moisture content the average length, width, thickness, unit mass, volume, geometric diameter, true density, porosity, static coefficient of friction, angle of repose and projected area for all varieties increased, while the rupture strength and bulk density decreased. The highest and lowest values of static coefficient of friction were obtained on plywood and glass surfaces, respectively. Also Iraqi1 variety had the highest values of all dimensional properties, mass, bulk density and true density but the lowest value of repose angle. Goli variety had the highest value of angle of repose whereas its other properties had lowest values compared to the other varieties.
Synthesis of graphene sheets and their application for transparent conductors

Graphene, a monolayer of sp -bonded carbon atoms or one monolayer of graphite, as a special atomically thick two dimensional structure and possesses unique mechanical, electrical, thermal and optical properties . These properties make graphene a good candidate mat erial for transparent conductors. Monolayer graphene oxide (G O) sheets with sizes ranging from a few to ~200 μm are synthesized based on a chemical method. In or der to obtain ultra-large graphene oxide (UL-GO), three main modifications we re made in our experiments: i) using the natural graphite with a large lateral size (up to ~800 μm) as starting material; ii) using intercalation and thermal shock to perform exfoliat ion, avoiding the destructive process of ultrasonication; iii) using a three-step centrifuga tion to sort the GO by sheet size. New thermal and chemical schemes, which include (i) a modified thermal treatment, (ii) acid treatment in a HNO 3 bath and (iii) doping by immersing in a SOBr 2 solution, are developed to treat graphene films to improve the el ectrical conductivity and transparency. It is
Phosphite-Mediated Suppression of Anthocyanin Accumulation Regulated by Mitochondrial ATP Synthesis and Sugars in Arabidopsis

Despite the essential role of phosphate (Pi) in plant growth and development, how plants sense and signal the change of Pi supply to adjust its uptake and utilization is not yet well understood. Pi itself has been proposed to be a signaling molecule that regulates Pi starvation responses (PSRs) because phosphite (Phi), a non-metabolized Pi analog, suppresses several PSRs. In this study, we identified a phosphite-insensitive1 (phi1) mutant which retained anthocyanin, a visible PSR, in Phi-containing but Pi-deficient medium. phi1 mutants were impaired in the gene encoding an FAd subunit of mitochondrial F1Fo-ATP synthase and showed a reduced mitochondrial ATP level in roots, growth hypersensitivity to oligomycin and an increased mitochondrial membrane potential, suggesting that this gene has a crucial role in mitochondrial ATP synthesis. phi1 mutants accumulated a high level of sugars in shoots, which may account for the increased accumulation of anthocyanin and starch in Phi-containing conditions. Gene expression analysis showed that a subset of genes involved in carbohydrate metabolism in phi1 was misregulated in response to Phi. The majority of genes were repressed by Pi starvation and, unlike wild-type plants, their repression in phi1 was not affected by the addition of Phi. Our findings show that defective mitochondrial ATP synthesis results in sugar accumulation, leading to alteration of Phi-mediated suppression of PSRs. This study reinforces the role of sugars, and also reveals a cross-talk among ATP, sugars and Pi/Phi molecules in mediating PSRs.
Older, Church-Going African Americans’ Attitudes and Expectations About Formal Depression Care

This phenomenological study involved focus groups with church-affiliated, African American women and men (N = 50; ages 50 and older) in southeast Michigan to determine their attitudes and expectations around formal mental health care. Data analysis employed a constant comparative approach and yielded themes related to formal mental health care, along with delineating concerns about defining depression, health, and well-being. Health and well-being were defined as inclusive of physical and spiritual aspects of self. Churches have a central role in how formal mental health care is viewed by their attendees, with prayer being an important aspect of this care. Provider expectations included privacy and confidentiality; respect for autonomy and need for information, having providers who discuss treatment options; and issues related to environmental cleanliness, comfort, and accessibility. Implications include providing effective, culturally tailored formal depression care that acknowledges and integrates faith for this group.
Epidermal growth factor receptor mutation status is strongly associated with smoking status in patients undergoing surgical resection for lung adenocarcinoma.

OBJECTIVES The purpose of this analysis was to examine the relationship between epidermal growth factor receptor (EGFR) mutation status and clinicopathological factors in a cohort of patients who underwent surgical resections for lung adenocarcinoma. METHODS From the patients who underwent surgical resections for primary lung cancers between 2005 and 2012, 371 consecutive adenocarcinoma patients were enrolled in this study, and their tumours were analysed for EGFR mutations. We examined the clinicopathological factors of all enrolled patients, including age, sex, pathological stage and smoking status and tested for associations with EGFR mutation status. RESULTS Among the 371 enrolled patients, 195 (52%) patients had EGFR mutations. There were significantly more women, never smokers and tumours of lower grade histology in the EGFR mutation group than in the wild-type group (P < 0.001 each). However, other factors, such as pathological stage and World Health Organization classification, were not significantly associated with mutation status. Multivariable analysis showed that age, smoking history and histological grade were independently associated with EGFR mutations (P = 0.026, P < 0.001 and P < 0.001, respectively), but sex was not. Regarding smoking status, especially, frequency of EGFR mutation decreased, as smoking index increased. On the other hand, sex and smoking cessation (whether the patients were former or current smokers) were not significantly associated with EGFR mutation status. CONCLUSIONS In our cohort of patients who underwent surgical resection for lung adenocarcinoma, EGFR mutation status was strongly associated with smoking status, especially smoking index.
European prospective multicentre study of hybrid thoracoscopic and transcatheter ablation of persistent atrial fibrillation: the HISTORIC‐AF trial†

OBJECTIVES The HISTORIC‐AF trial is a prospective, multicentre, single‐arm study designed to evaluate the outcomes of a staged endoscopic and transcatheter ablation in patients with stand‐alone, persistent or long‐standing persistent atrial fibrillation (AF). METHODS From 2012 to 2015, 100 consecutive patients were enrolled and underwent thoracoscopic left atrial epicardial isolation (‘box lesion’) followed by transcatheter ablation in case of AF recurrency. The safety end point was the composite outcome of freedom from major adverse events at 30‐days, while efficacy end points were: (i) primary: freedom from AF and stable sinus rhythm following isolated thoracospic ablation >60% and (ii) secondary: freedom from AF and stable sinus rhythm >80% following hybrid ablation (as per HRS criteria). RESULTS No death occurred and surgical thoracoscopic procedure was successfully completed in all patients. Survival free from major adverse events at 30 days was 94%: there were 3 permanent pacemaker implants, 2 episodes of stroke and 1 revision for bleeding. At discharge, 87% of patients were in sinus rhythm. A staged transcatheter ablation was carried out in all patients with AF recurrences at the end of 3 months blanking period (17% of patients). At 12‐months follow‐up, a stable restoration of sinus rhythm was achieved in 75% and 88% of patients following isolated thoracoscopic ablation and hybrid ablation, respectively. CONCLUSIONS The HISTORIC‐AF trial showed that thoracoscopic isolated surgical ablation reached both the safety and the efficacy end points. Hybrid ablation steadily improved rhythm outcomes and may be considered in the future as the treatment of choice for patients with persistent and long‐standing persistent AF. ClinicalTrials.gov Identifier NCT01622907.
Thermoelectric Materials

The ever-increasing concerns on energy crisis and sustainable resources have spurred a worldwide action in developing alternative energy conversion technologies. Thermoelectric materials, which provide a promising solution for the conversion of heat into electricity and vice versa, have attracted increasing attention in the fields of solid-state physics, chemistry and materials science. From the perspective of historical development, the past two decades have witnessed surged advances in thermoelectrics, featured by the deeper understanding of thermoelectric physics, establishment of novel optimization strategies, discovery of novel thermoelectric materials, success of high-efficiency thermoelectric devices, and practical applications of thermoelectric technologies in multiple areas of public life. To promote the wide applications of thermoelectric technologies, one fundamental issue lies in the improvement of the conversion efficiency of thermoelectric devices, which is directly tied to the dimensionless figure of merit zT of thermoelectric materials. There are two main research directions in the development of thermoelectricmaterials: one is to deeply understand the transport mechanism of existing good thermoelectric materials and thereby further enhance the zT; the other is to explore new thermoelectric candidates using the established thermoelectric guidelines. In reality, the progress of both directions is strongly related to the advances in solid-state physics. Namely, the discovery of new electronic and phononic structures and the insightful understanding of electron and phonon transport mechanisms in the solid-state materials will bring new opportunities for the thermoelectric field. This special issue of the Annalen der Physik on “Thermoelectric Materials” contains eight original articles and one review article on the dynamic of various thermoelectric studies. The topics range from the understanding of thermoelectric band engineering and scattering mechanism, and the interplay between spintronics and thermoelectrics, to the discovery of new thermoelectric semiconductors. AgSbTe2, as an interesting ternary thermoelectric material, attracts considerable attention with the focus on the origin of its intrinsically low thermal conductivity and high thermoelectric performance. In the first original article, Liu et al.[1] report that
A probabilistic model-based bi-clustering method for single-cell transcriptomic data analysis

We present here novel computational techniques for tackling four problems related to analyses of single-cell RNA-Seq data: (1) a mixture model for coping with multiple cell types in a cell population; (2) a truncated model for handling the unquantifiable errors caused by large numbers of zeros or low-expression values; (3) a bi-clustering technique for detection of sub-populations of cells sharing common expression patterns among subsets of genes; and (4) detection of small cell sub-populations with distinct expression patterns. Through case studies, we demonstrated that these techniques can derive high-resolution information from single-cell data that are not feasible using existing techniques.
Robust Fault-Tolerant Tracking Control for Spacecraft Proximity Operations Using Time-Varying Sliding Mode

The capture of a free-floating tumbling object using an autonomous vehicle is a key technology for many future orbital missions. Spacecraft proximity operations will play an important role in guaranteeing the success of such missions. In this paper, we technically propose a tracking control scheme for proximity operations between a target and a pursuer spacecraft that ensures accurate relative position tracking as well as attitude synchronization. Specifically, an integrated six degrees of freedom dynamics model is first established to describe the relative motion of the pursuer with respect to the target. Then, a robust fault-tolerant controller is derived by combining the sliding mode control and the adaptive technique. The designed controller is proved to be not only robust against unexpected disturbances and adaptive to unknown and uncertain mass/inertia properties of the pursuer, but also able to accommodate a large class of actuator faults. In particular, by incorporating a novel time-varying forcing function into the sliding dynamics, the proposed control algorithm is able to guarantee the finite-time convergence of the translational and rotational tracking errors, and the convergence time as an explicit parameter can be assigned a priori by the designers. Furthermore, a theoretical analysis is also presented to assess the fault tolerance ability of the designed controller. Finally, numerous examples are carried out to evaluate the effectiveness and demonstrate the benefits of the overall control approach.
The role of shear wave elastography in the assessment of placenta previa–accreta

Abstract Objective: To evaluate the value of shear wave elastography (SWE) in the prediction of morbidly adherent placenta. Methods: Forty-three women with normal placental location and 26 women with anteriorly localized placenta previa were recruited for this case-control study. Placental elasticity values in both the groups were determined by SWE imaging. Results: SWE values were higher in the placenta previa group in all regions than in normal localized placentas (p < .01). However, there was no statistically significant difference between SWE values of placenta previa with and without morbidly adherent placenta (p > .05). Conclusions: Placental stiffness is significantly higher in placenta previa than normal localized placentas. However, we could not demonstrate any statistically significant difference in the elasticity values between the placenta previa with and without accreta.