Miracle-dz/UniFAR-FTUs huggingface dataset:
Parathyroid Hormone (PTH)–Induced Bone Gain Is Blunted in SOST Overexpressing and Deficient Mice

Intermittent parathyroid hormone (PTH) treatment is a potent bone anabolic principle that suppresses expression of the bone formation inhibitor Sost. We addressed the relevance of Sost suppression for PTH‐induced bone anabolism in vivo using mice with altered Sost gene dosage. Six‐month‐old Sost overexpressing and 2‐month‐old Sost deficient male mice and their wild‐type littermates were subjected to daily injections of 100 µg/kg PTH(1–34) or vehicle for a 2‐month period. A follow‐up study was performed in Sost deficient mice using 40 and 80 µg/kg PTH(1–34). Animals were sacrificed 4 hours after the final PTH administration and Sost expression in long bone diaphyses was determined by qPCR. Bone changes were analyzed in vivo in the distal femur metaphysis by pQCT and ex vivo in the tibia and lumbar spine by DXA. Detailed ex vivo analyses of the femur were performed by pQCT, µCT, and histomorphometry. Overexpression of Sost resulted in osteopenia and Sost deletion in high bone mass. As shown before, PTH suppressed Sost in wild‐type mice. PTH treatment induced substantial increases in bone mineral density, content, and cortical thickness and in aging wild‐type mice also led to cancellous bone gain owing to amplified bone formation rates. PTH‐induced bone gain was blunted at all doses and skeletal sites in Sost overexpressing and deficient mice owing to attenuated bone formation rates, whereas bone resorption was not different from that in PTH‐treated wild‐type controls. These data suggest that suppression of the bone formation inhibitor Sost by intermittent PTH treatment contributes to PTH bone anabolism. © 2010 American Society for Bone and Mineral Research
From the margins to the mainstream : imagining socioecological futures in Wales

In light of widespread claims about a lack of imagination in response to socioecological crises, this study explores various projects in Wales in order to critically examine the kinds of imaginaries of socioecological transformation that these projects are generating. The Welsh Government’s pioneering Well-being of Future Generations Act (2015) provides the context for the research, and this study presents the first critical analysis of this new legislation, and the imaginaries associated with it. Alongside this analysis, however, the study also takes more marginal projects and practices seriously as forms of “minor theory” that might present alternative ways of doing things. To this end, the study has engaged with a range of projects that are envisioning socioecological transformation, including projects in the arts, alternative agriculture, and renewable energy. The study thus engages with imaginaries of socioecological transformation “from the margins to the mainstream”, not by positing these imaginaries as “unimportant” as opposed to “important” (respectively), but by seeking to give equal attention to the political potential of the kinds of ideas that are in play, and what kinds of socioecological futures these ideas make possible. Collective imaginaries of socioecological crises, and the ideas that sustain them, are an important field of struggle with regard to how particular forms of transformation are, or are not, set in motion. The thesis explores three main themes: time and futurity, human–environment relations, and the role of art in socioecological transformation, and shows how notions of complexity, non-linearity, and more-than-human agency emerge as important ideas, and often in unexpected or overlooked places. The research is based on combinations of participant observation, interview, and document analysis, and adopts a standpoint that research does not simply represent how worlds are made, but also participates in their making.
Context sensitive stemming for web search

Traditionally, stemming has been applied to Information Retrieval tasks by transforming words in documents to the their root form before indexing, and applying a similar transformation to query terms. Although it increases recall, this naive strategy does not work well for Web Search since it lowers precision and requires a significant amount of additional computation. In this paper, we propose a context sensitive stemming method that addresses these two issues. Two unique properties make our approach feasible for Web Search. First, based on statistical language modeling, we perform context sensitive analysis on the query side. We accurately predict which of its morphological variants is useful to expand a query term with before submitting the query to the search engine. This dramatically reduces the number of bad expansions, which in turn reduces the cost of additional computation and improves the precision at the same time. Second, our approach performs a context sensitive document matching for those expanded variants. This conservative strategy serves as a safeguard against spurious stemming, and it turns out to be very important for improving precision. Using word pluralization handling as an example of our stemming approach, our experiments on a major Web search engine show that stemming only 29% of the query traffic, we can improve relevance as measured by average Discounted Cumulative Gain (DCG5) by 6.1% on these queriesand 1.8% over all query traffic.
Rational use of the fixed combination of dorzolamide – timolol in the management of raised intraocular pressure and glaucoma

Glaucoma is a multifactorial optic neuropathy in which the main therapeutic target is lowering of intraocular pressure (IOP) in order to retard the progression of existing structural and functional damage. The three mainstays of treatment are pharmacologic, laser, and surgical. The primary standard therapy in patients with open-angle glaucoma or ocular hypertension is topical medication. When monotherapy does not adequately lower the intraocular pressure, one or more agents are added or substituted. Combination pharmacotherapy such as Cosopt® is available to improve efficacy and simplify medication regimen. A fixed combination of two ocular hypotensive drugs (the carbonic anhydrase inhibitor dorzolamide and the beta-adrenoceptor antagonist timolol), Cosopt® is indicated for the treatment of elevated IOP in patients with open-angle glaucoma or ocular hypertension insufficiently responsive to topical beta-adrenoceptor antagonist monotherapy. Compared with concomitant therapy with the individual components, the primary advantage of fixed combination dorzolamide – timolol is convenience, which may also improve compliance. Clinical trials have demonstrated that the fixed combination dorzolamide – timolol is safe, effective and generally well tolerated in lowering IOP in patients with open angle glaucoma or ocular hypertension, including individuals uncontrolled on beta-adrenoceptor antagonist or other monotherapy.
The Reluctant Audience: Online Participation in the Swedish Journalistic Context

With new media technology everyone online can easily participate in creating news content. This is usually considered positive from a societal, democratic point of view, even if audience interaction is not necessarily seen as a positive feature by editors and journalists. As a response to the somewhat scarce research in this field, this article analyses a Swedish mail questionnaire survey on audience behaviour and attitudes in these matters. The analysis shows that there is only relatively little interest, from a general audience point of view, in participating in creating content on news sites. Likewise, the minority who are actually commenting on news articles, or otherwise participating in the journalistic process through blog-writing, seem to consider these activities as part of a creative leisure-time, rather than as partaking in democratic activities. The article further argues that the use of interactive facilities and content creation in the journalistic context tend to be yet another tool for persons already possessing substantial competence about society and political life and who are already busy in the online world.
Measuring Attitude Toward Lucid Dreams: A Six-Item Scale

In recent years, the interest in lucid dreaming (dreaming with the conscious knowledge that one is dreaming) was stimulated by blockbuster films like “Inception” and the media interest in studies indicating that lucid dreaming can be beneficial. However, systematic studies regarding the attitude toward lucid dreams are lacking. An online survey was completed by 1,380 persons (777 women and 603 men), whose mean age was 51.63 ± 14.13 years. The six-item scale measuring attitude toward lucid dreams showed high internal consistency. The attitude toward lucid dreams was highly correlated with the general attitude toward lucid dreams and decreased with age; women reported a more positive attitude. However, the attitude toward lucid dreams was markedly lower than the attitude toward dreams in general. It would be interesting to study what the bases of the attitude toward lucid dreams are, for example, information in the media, personal experience, and reports of friends.
Fast computation of shadow boundaries using spatial coherence and backprojections

This paper describes a fast, practical algorithm to compute the shadow boundaries in a polyhedral scene illuminated by a polygonal light source. The shadow boundaries divide the faces of the scene into regions such that the structure or “aspect” of the visible area of the light source is constant within each region. The paper also describes a fast, practical algorithm to compute the structure of the visible light source in each region. Both algorithms exploit spatial coherence and are the most efficient yet developed. Given the structure of the visible light source in a region, queries of the form “What specific areas of the light source are visible? ” can be answered almost instantly from any point in the region. This speeds up by several orders of magnitude the accurate computation of first level diffuse reflections due to an area light source. Furthermore, the shadow boundaries form a good initial decomposition of the scene for global illumination computations.
A General Iterative Method for Variational Inequality Problems, Mixed Equilibrium Problems, and Fixed Point Problems of Strictly Pseudocontractive Mappings in Hilbert Spaces

We introduce an iterative scheme for finding a common element of the set of fixed points of a -strictly pseudocontractive mapping, the set of solutions of the variational inequality for an inverse-strongly monotone mapping, and the set of solutions of the mixed equilibrium problem in a real Hilbert space. Under suitable conditions, some strong convergence theorems for approximating a common element of the above three sets are obtained. As applications, at the end of the paper we first apply our results to study the optimization problem and we next utilize our results to study the problem of finding a common element of the set of fixed points of two families of finitely -strictly pseudocontractive mapping, the set of solutions of the variational inequality, and the set of solutions of the mixed equilibrium problem. The results presented in the paper improve some recent results of Kim and Xu (2005), Yao et al. (2008), Marino et al. (2009), Liu (2009), Plubtieng and Punpaeng (2007), and many others.
Concord and Niagara Grape Juice and Their Phenolics Modify Intestinal Glucose Transport in a Coupled in Vitro Digestion/Caco-2 Human Intestinal Model

While the potential of dietary phenolics to mitigate glycemic response has been proposed, the translation of these effects to phenolic rich foods such as 100% grape juice (GJ) remains unclear. Initial in vitro screening of GJ phenolic extracts from American grape varieties (V. labrusca; Niagara and Concord) suggested limited inhibitory capacity for amylase and α-glucosidase (6.2%–11.5% inhibition; p < 0.05). Separately, all GJ extracts (10–100 µM total phenolics) did reduce intestinal trans-epithelial transport of deuterated glucose (d7-glu) and fructose (d7-fru) by Caco-2 monolayers in a dose-dependent fashion, with 60 min d7-glu/d7-fru transport reduced 10%–38% by GJ extracts compared to control. To expand on these findings by assessing the ability of 100% GJ to modify starch digestion and glucose transport from a model starch-rich meal, 100% Niagara and Concord GJ samples were combined with a starch rich model meal (1:1 and 1:2 wt:wt) and glucose release and transport were assessed in a coupled in vitro digestion/Caco-2 cell model. Digestive release of glucose from the starch model meal was decreased when digested in the presence of GJs (5.9%–15% relative to sugar matched control). Furthermore, transport of d7-glu was reduced 10%–38% by digesta containing bioaccessible phenolics from Concord and Niagara GJ compared to control. These data suggest that phenolics present in 100% GJ may alter absorption of monosaccharides naturally present in 100% GJ and may potentially alter glycemic response if consumed with a starch rich meal.
A crosslinguistic study of prosodic focus

We examined the production and perception of (contrastive) prosodic focus, using a paradigm based on digit strings, in which the same material and discourse contexts can be used in different languages. We found a striking difference between languages like English and Mandarin Chinese, where prosodic focus is clearly marked in production and accurately recognized in perception, and languages like Korean, where prosodic focus is neither clearly marked in production nor accurately recognized in perception. We also present comparable production data for Suzhou Wu, Japanese, and French.
MR detection of brain iron.

PURPOSE To provide further quantitative studies concerning the relationship with age between regional brain iron and T2 shortening. METHODS a) Quantitative T2 calculations of eight anatomic regions (red nucleus, substantia nigra, dentate nucleus, corpus callosum, caudate, putamen, temporal lobe white matter, and frontal lobe white matter) from T2-weighted spin-echo images were performed in 60 patients aged newborn to 35 years. b) Quantitative brain iron concentrations were obtained in six of the eight anatomic regions (red nucleus, substantia nigra, dentate nucleus, corpus callosum, cauda, and putamen) using 13 autopsied brains (newborn to 78 years). Brain tissue from these six regions was digested with 0.6 N HCl-2.5% wt/vol KMnO4 for 2 hours at 60 degrees C. After centrifugation, 0.1 mL of an iron-chelating reagent (2 mol/L ascorbic acid, 5 mol/L ammonium acetate, 6.5 nmol/L ferrozine, 13.1 mmol/L neocuprine) was added and the absorbance was measured at 562 nm/L and compared with a standard curve with ferric chloride. c) The in vivo iron concentrations in tissue that were obtained were reproduced in four test tube phantom studies with ferric ammonium sulfate or ferrous ammonium sulfate dissolved in either deionized water or 5% agarose. T2 calculations of the phantoms were made with a single-section multiple repetition time, multiple echo time acquisition. RESULTS a) Clinical T2 calculations--all eight anatomic regions showed a decrease with age in T2 value, beginning shortly after birth. During the first three decades, the T2 shortening was most significant in the region of substantia nigra. b) Quantitative brain iron--five anatomic regions but not the corpus callosum demonstrated an age-related increase in brain iron (1449.6 nmol/g for the red nucleus versus 261.8 nmol/g for the corpus callosum). c) T2 effect of iron in vitro--both the ferric and ferrous iron phantoms showed a decreased T2 value in the in vivo concentration range of iron obtained from the postmortem studies. The T2 shortening was most marked for the ferric phantoms. CONCLUSION There is an age-related accumulation of iron in five regions of the brain, correlating with an associated decrease in T2 value that can be demonstrated in iron phantoms. Brain iron appears to contribute to the progressive decrease of T2 signal that occurs with aging.
Dicer Inactivation Leads to Progressive Functional and Structural Degeneration of the Mouse Retina

MicroRNAs (miRNAs) are small, highly conserved molecules that have been shown to regulate the expression of genes by binding to specific target mRNAs. Dicer, an RNase III endonuclease, is essential for the production and function of mature miRNAs, and removal of Dicer has been shown to disrupt many developmental processes. In this study, Dicer was removed specifically from the retina using a floxed Dicer conditional allele and the retinal Chx10Cre transgene. Retinal Dicer knock-out mice displayed a reproducible inability to respond to light. In addition, morphological defects were observed with the formation of photoreceptor rosettes at postnatal day 16, which progressed to more general cellular disorganization and widespread degeneration of retinal cell types as the animals aged. This was accompanied by concomitant decrease in both scotopic and photopic electroretinogram (ERG) responses. Interestingly, removing a single allele of Dicer resulted in ERG deficits throughout life but not to morphological abnormalities. Northern blot analysis of Dicer-depleted retinas showed a decrease in several miRNAs. The observation that progressive retinal degeneration occurred after removal of Dicer raises the possibility that miRNAs are involved in retinal neurodegenerative disorders.
WARM DARK MATTER MODEL OF GALAXY FORMATION

Cold Dark Matter (CDM) models of galaxy formation had been remarkably successful to explain a number of observations in the past decade. However, with both the theoretical modeling and the observations being improved, CDM models have been very recently shown to have excessive clustering on the sub-galactic scale. Here we discuss a solution, based on our high-resolution numerical simulations, to this outstanding problem by considering Warm Dark Matter (WDM). Our results show that the over-clustering problem on sub-galactic scales can be overcome by WDM models, and all the advantages of CDM models are preserved by WDM models. Therefore, the WDM model will become an interesting alternative to the well-studied CDM models.
Neurocognitive Changes among Elderly Exposed to PCBs/PCDFs in Taiwan

Background In 1979 approximately 2,000 people were exposed to polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) due to ingestion of contaminated cooking oil in Taiwan. Although a previous study has shown delayed developmental milestones and poorer neurocognitive functioning in children born to exposed mothers, it is unclear whether neurocognitive functioning was impaired in people who were directly exposed to the PCBs and PDCFs. Objective The objective of this study was to compare neurocognitive functioning in people exposed to PCBs and PCDFs with that of unexposed sex- and age-matched neighbors. Methods We conducted a retrospective cohort study among exposed and unexposed subjects ≥60 years of age using prospective outcome measurements. We evaluated neurocognitive tests including cognition, memory modalities, learning, motor and sensory function, mood, and daily activity. Results In total, 162 (59%) exposed and 151 (55%) reference subjects completed this study. In exposed men, all test results were similar to the reference group; however, exposed women had reduced functioning in attention and digit span (ADS), visual memory span (VMS), and verbal memory recalls (VMR), especially learning ability. We also found a borderline reduction in the Mini-Mental State Examination. The digit symbol, motor, sensory, depression (determined by the Geriatric Depression Scale-Short Form), and activity of daily life were not different between the exposed and reference groups. A significant dose–response relationship was found for VMR, ADS, and VMS. Conclusion Our study showed dose-dependent neurocognitive deficits in certain aspects of attention, visual memory, and learning ability in women previously exposed to PCBs and PCDFs, but not in exposed men.
Amygdala neural activity reflects spatial attention towards stimuli promising reward or threatening punishment

Humans and other animals routinely identify and attend to sensory stimuli so as to rapidly acquire rewards or avoid aversive experiences. Emotional arousal, a process mediated by the amygdala, can enhance attention to stimuli in a non-spatial manner. However, amygdala neural activity was recently shown to encode spatial information about reward-predictive stimuli, and to correlate with spatial attention allocation. If representing the motivational significance of sensory stimuli within a spatial framework reflects a general principle of amygdala function, then spatially selective neural responses should also be elicited by sensory stimuli threatening aversive events. Recordings from amygdala neurons were therefore obtained while monkeys directed spatial attention towards stimuli promising reward or threatening punishment. Neural responses encoded spatial information similarly for stimuli associated with both valences of reinforcement, and responses reflected spatial attention allocation. The amygdala therefore may act to enhance spatial attention to sensory stimuli associated with rewarding or aversive experiences. DOI: http://dx.doi. org/10.7554/eLife.04478. 001
A modified EBMT risk score and the hematopoietic cell transplantation-specific comorbidity index for pre-transplant risk assessment in adult acute lymphoblastic leukemia

Background Disease stage is the most important prognostic parameter in allogeneic hematopoietic cell transplantation (HCT) for acute lymphoblastic leukemia, but other factors such as donor/host histocompatibility and gender combination, recipient age, performance status and comorbidities need to be considered. Several scoring systems are available to predict outcome in HCT recipients; however, their prognostic relevance in acute lymphoblastic leukemia is not well defined. Design and Methods In the present study we evaluated a modified EBMT risk score (mEBMT) and the HCT-specific comorbidity index (HCT-CI) in 151 adult acute lymphoblastic leukemia patients who received allogeneic HCT from 1995 until 2007 at our center. Results Disease status was first complete remission (CR1) (47%), CR>1 (21%) or no CR (32%). Overall survival (OS) at one, two and five years was 62%, 51% and 40% and non-relapse mortality (NRM) was 21%, 24% and 32%. Median mEBMT was 3 (0–6). Higher mEBMT was associated with inferior OS (hazard ratio per score unit (HR): 1.50, P<0.001), higher NRM (HR: 1.36, P=0.042) and higher relapse mortality (HR: 1.68, P<0.001). Disease stage was the predominant prognostic factor in this score. Comorbidities were present in 71% of patients with mild hepatic disease (29%), moderate pulmonary disease (28%) and infections (23%) being the most common. Median HCT-CI was 1 (0–9). In univariate analysis a trend for inferior OS (HR: 1.08, P=0.20) and higher NRM (HR: 1.14, P=0.11) with increasing HCT-CI was observed but the level of significance was not reached. In additional analyses we found that reduced Karnofsky Performance Status (KPS) was associated with inferior OS (HR: 1.34, P=0.023) and higher relapse mortality (HR: 1.71, P=0.001) when analyzed univariately. However, KPS was associated with disease stage and significance was lost in multivariate analysis. Conclusions The mEBMT was prognostic in our patient cohort with predominant influence of disease stage, whereas a trend but no significant prognostic value was observed for the HCT-CI.