Miracle-dz/UniFAR-FTUs huggingface dataset:
Expanding roles in a library-based bioinformatics service program: a case study.

QUESTION How can a library-based bioinformatics support program be implemented and expanded to continuously support the growing and changing needs of the research community? SETTING A program at a health sciences library serving a large academic medical center with a strong research focus is described. METHODS The bioinformatics service program was established at the Norris Medical Library in 2005. As part of program development, the library assessed users' bioinformatics needs, acquired additional funds, established and expanded service offerings, and explored additional roles in promoting on-campus collaboration. RESULTS Personnel and software have increased along with the number of registered software users and use of the provided services. CONCLUSION With strategic efforts and persistent advocacy within the broader university environment, library-based bioinformatics service programs can become a key part of an institution's comprehensive solution to researchers' ever-increasing bioinformatics needs.
Fatal coccidioidomycosis. Report of two cases.

intestinal tract than in other single organs. Moertel noted that often in such cases the primary lesions are close to each other. The occasional metastasis of one tumor into another has been termed "collision. "13 Although there are several reports of collision metastasis13-15 we find no report of a case similar to this one, in which there was metastasis to a single lymph node from two primary carcinomas.
Putting it into words : the impact of visual impairment on perception, experience and presence

The experience of being “present” in a mediated environment, such that it appears real, is known to be affected by deficits in perception yet little research has been devoted to disabled audiences. People with a visual impairment access audiovisual media by means of Audio Description, which gives visual information in verbal form. The AD user plays an active role, engaging their own perceptual processing systems and bringing real-world experiences to the mediated environment. In exploring visual impairment and presence, this thesis concerns a question fundamental to psychology, whether propositional and experiential knowledge equate. It casts doubt on current models of sensory compensation in the blind and puts forward an alternative hypothesis of linguistic compensation. Qualitative evidence from Study 1 suggests that, in the absence of bimodal (audio-visual) cues, words can compensate for missing visual information. The role of vision in multisensory integration is explored experimentally in Studies 2 and 3. Crossmodal associations arising both from direct perception and imagery are shown to be altered by visual experience. Study 4 tests presence in an auditory environment. Non-verbal sound is shown to enhance presence in the sighted but not the blind. Both Studies 3 and 4 support neuroimaging evidence that words are processed differently in the absence of sight. Study 5, comparing mental spatial models, suggests this is explained by explicit verbal encoding by people with a visual impairment. Study 6 tests the effect of words on presence and emotion elicitation in an audiovisual environment. In the absence of coherent information from the dialogue, additional verbal information significantly improves understanding. Moreover, in certain circumstances, Audio Description significantly enhances presence and successfully elicits a target emotion. A model of Audio Description is presented. Implications are discussed for theoretical models of perceptual processing and presence in those with and without sight.
Grid Design for Efficient and Accurate Point Mass Filter-Based Terrain Referenced Navigation

This paper proposes an optimal grid design method for point mass filter-based terrain referenced navigation (PTRN) by considering the process and measurement uncertainties or noise to efficiently obtain accurate results. The estimation performance of the point mass filter (PMF) is generally known to improve when very large support and a high-resolution grid are implemented. However, when this condition is applied to the PTRN, the algorithm cannot be executed in real-time due to the high computational load. In addition, even though the grid condition is improved, the filter accuracy is limited by the given process and measurement noises. Therefore, it is possible to perform efficient and accurate PTRN by finding the minimum number of grid points that can achieve the maximum performance. In this paper, a grid design method is carried out by considering each noise, and the selection logic between the two design results are proposed. By applying the proposed grid design method, it is possible to obtain almost the same accuracy as the results that are obtained when a very high resolution is applied, with a much lower computational load, and it is expected for the highly accurate PTRN to be available in real-time.
Performance Analysis of Subsea Pipeline Defect Classification Using Supervised Machine Learning

Subsea pipelines are pivotal to a country’s economy. These pipelines not only ensure safe and efficient transportation of gas, oil, and other refined products but also enable continuous flow of oil and gas to onshore reserves, thereby maintaining a consistent supply to meet energy demands. However, these pipelines are exposed to extreme variations in temperature and pressure which makes them susceptible to defects early in their operational life which if left untreated can potentially lead to irreversible environmental damage. This necessitates regular integrity assessment of the subsea infrastructure. Inspection of subsea pipelines involves the arduous task of reviewing inspection video footage with extreme precision. To automate the process of inspection, a comparative study of four different multi-class classification models that can classify the underwater pipeline inspection images into three distinct classes namely corroded, cracked and healthy pipes, has been evaluated. The classifiers considered for the study are EfficientNetB0, MobileNetV2, ResNet50 and VGG-16. Among the considered models, VGG-16 has shown the highest overall classification accuracy of 99.04%.
Tracheostomy does not improve the outcome of patients requiring prolonged mechanical ventilation: A propensity analysis*

Objective: To examine the association between the performance of a tracheostomy and intensive care unit and postintensive care unit mortality, controlling for treatment selection bias and confounding variables. Design: Prospective, observational, cohort study. Setting: Twelve French medical or surgical intensive care units. Patients: Unselected patients requiring mechanical ventilation for ≥48 hrs enrolled between 1997 and 2004. Interventions: None. Measurements and Main Results: Two models of propensity scores for tracheostomy were built using multivariate logistic regression. After matching on these propensity scores, the association of tracheostomy with outcomes was assessed using multivariate conditional logistic regression. Results obtained with the two models were compared. Of the 2,186 patients included, 177 (8.1%) received a tracheostomy. Both models led to similar results. Tracheostomy did not improve intensive care unit survival (model 1: odds ratio, 0.94; 95% confidence interval, 0.63–1.39; p = .74; model 2: odds ratio, 1.12; 95% confidence interval, 0.75–1.67; p = .59). There was no difference whether tracheostomy was performed early (within 7 days of ventilation) or late (after 7 days of ventilation). In patients discharged free from mechanical ventilation, tracheostomy was associated with increased postintensive care unit mortality when the tracheostomy tube was left in place (model 1: odds ratio, 3.73; 95% confidence interval, 1.41–9.83; p = .008; model 2: odds ratio, 4.63; 95% confidence interval, 1.68–12.72, p = .003). Conclusions: Tracheostomy does not seem to reduce intensive care unit mortality when performed in unselected patients but may represent a burden after intensive care unit discharge.
Learning Arbitrary Potentials in CRFs with Gradient Descent

Are we using the right potential functions in the Markov- and Conditional- Random Field graphical models that are popular in the Vision community? Semantic segmentation and other pixel-level labelling tasks have made significant progress recently due to the deep learning paradigm. However, most state-of-the-art structured prediction methods also include a random field model with a hand-crafted Gaussian potential to model spatial priors, label consistencies and feature-based image conditioning. In this paper, we challenge this view by introducing a new inference and learning framework which can learn arbitrary pairwise CRF potentials. Both standard spatial and high-dimensional bilateral kernels are considered. Our framework is based on the observation that CRF inference can be achieved via projected gradient descent and consequently, can easily be integrated in deep neural networks to allow for end-to-end training. We compare our approach to several other recent frameworks, both from a theoretical and experimental perspective, and conclude that one can improve performance by using learned potentials.
EFL learners’ awareness of metonymy–metaphor continuum in figurative expressions

Most studies about figurative language learning focus on metaphor rather than metonymy; however, the interactions of metonymy and metaphor are so intricate that the boundary forms not a dichotomy but a continuum. Such a continuum and its influences on figurative language learning have not been studied in depth. The present study investigates EFL (English as a Foreign Language) learners’ responses to different metonymic and metaphoric expressions. Twenty-eight Taiwanese EFL learners participated in the study, which asked them to rate 40 sentences based on their certainty of figurative language use. The results show that EFL learners were capable of distinguishing between sentences with and without figurative expressions, and were more certain in judging metaphoric expressions than metonymic ones. Moreover, they found it easier to recognise expressions of the emotion anger than those of other topics. Their performances indicate that EFL learners are able to use their shared experiences to identify figurative language uses. This study suggests that it may be beneficial to integrate ideas of conceptual metonymy and metaphor to raise learners’ awareness of abstract but universal concepts involved in figurative expressions.
Loss of Lung Health from Young Adulthood and Cardiac Phenotypes in Middle Age.

RATIONALE Chronic lung diseases are associated with cardiovascular disease. How these associations evolve from young adulthood forward is unknown. Understanding the preclinical history of these associations could inform prevention strategies for common heart-lung conditions. OBJECTIVES To use the Coronary Artery Risk Development in Young Adults (CARDIA) study to explore the development of heart-lung interactions. METHODS We analyzed cardiac structural and functional measurements determined by echocardiography at Year 25 of CARDIA and measures of pulmonary function over 20 years in 3,000 participants. MEASUREMENTS AND MAIN RESULTS Decline in FVC from peak was associated with larger left ventricular mass (β = 6.05 g per SD of FVC decline; P < 0.0001) and greater cardiac output (β = 0.109 L/min per SD of FVC decline; P = 0.001). Decline in FEV1/FVC ratio was associated with smaller left atrial internal dimension (β = -0.038 cm per SD FEV1/FVC decline; P < 0.0001) and lower cardiac output (β = -0.070 L/min per SD of FEV1/FVC decline; P = 0.03). Decline in FVC was associated with diastolic dysfunction (odds ratio, 3.39; 95% confidence interval, 1.37-8.36; P = 0.006). CONCLUSIONS Patterns of loss of lung health are associated with specific cardiovascular phenotypes in middle age. Decline in FEV1/FVC ratio is associated with underfilling of the left heart and low cardiac output. Decline in FVC with preserved FEV1/FVC ratio is associated with left ventricular hypertrophy and diastolic dysfunction. Cardiopulmonary interactions apparent with common complex heart and lung diseases evolve concurrently from early adulthood forward.
Joint direction-of-arrival and array shape tracking for multiple moving targets

An algorithm for the joint tracking of source DOAs and sensor positions is presented to address the problem of DOA tracking in the presence sensor motion. Initial maximum likelihood estimates of source DOAs and sensor positions are refined by Kalman filtering. Spatio-temporally correlated array movement is considered. Source angle dynamics are used to achieve correct data association. The new technique is capable of performing well for the difficult cases of sources that cross in angle, fully coherent sources, as well as sources of identical or vastly different (possibly time-varying) power. Computer simulations show that the approach is robust in the presence of array motion modeling uncertainty and effectively reduces dependence on expensive and possibly unreliable hardware.
The Communication Skills of Accountants: What we Know and the Gaps in our Knowledge

Abstract This paper critically reviews 19 studies published between 1972 and 2012 that investigated the written and/or oral communication skills of practicing accountants. The core aim of the review was to identify skills considered important and highlight gaps regarding what is known about existing and desired communication skills in the accounting profession. Key findings include that most studies did not detail the basis used to select the skills examined, used very broad skill-set categories and/or did not sufficiently incorporate information already established in the literature. Differing views on the importance of communication skills were found between educators and accountants. Knowledge gaps identified relate to the communication skills considered most important at varying career stages and different career paths, the specific types of oral and written communication skills needed and the role and importance of oral versus written and informal versus formal communication skills. A fundamental concern is that much of the existing communication skills research is crucially out of date. Of the 19 studies reviewed, only three have been published in the past decade. This suggests that further research is needed in the area.
The history of the use of self-reports and the methodology of economics

The main arguments currently held for and against the use of self-reports in economics are presented in their relation to well-known events in the history of the discipline: the ‘measurement without theory’, the ‘full-cost’, and the ‘economic expectations’ controversies. Doing so, the paper highlights the so far neglected role of George Katona's behavioral economics in these methodological discussions.
Path Control: A Method for Patient-Cooperative Robot-Aided Gait Rehabilitation

Gait rehabilitation robots are of increasing importance in neurorehabilitation. Conventional devices are often criticized because they are limited to reproducing predefined movement patterns. Research on patient-cooperative control strategies aims at improving robotic behavior. Robots should support patients only as much as needed and stimulate them to produce maximal voluntary efforts. This paper presents a patient-cooperative strategy that allows patients to influence the timing of their leg movements along a physiologically meaningful path. In this ¿path control¿ strategy, compliant virtual walls keep the patient's legs within a ¿tunnel¿ around the desired spatial path. Additional supportive torques enable patients to move along the path with reduced effort. Graphical feedback provides visual training instructions. The path control strategy was evaluated with 10 healthy subjects and 15 subjects with incomplete spinal cord injury. The spatio-temporal characteristics of recorded kinematic data showed that subjects walked with larger temporal variability with the new strategy. Electromyographic data indicated that subjects were training more actively. A majority of iSCI subjects was able to actively control their gait timing. Thus, the strategy allows patients to train walking while being helped rather than controlled by the robot.
Meta-Analysis of Comparative Trials Evaluating a Prophylactic Single-Use Negative Pressure Wound Therapy System for the Prevention of Surgical Site Complications

Abstract Background: We report the first meta-analysis on the impact of prophylactic use of a specific design of negative pressure wound therapy (NPWT) device on surgical site complications. Methods: Articles were identified in which the specific single-use NPWT device (PICO⋄, Smith & Nephew) was compared with standard care for surgical site infection (SSI), dehiscence, or length of stay (LOS). Risk ratio (RR) ±95% confidence interval (CI) (SSI; dehiscence) or mean difference in LOS ±95% CI was calculated using RevMan v5.3. Results: There were 1863 patients (2202 incisions) represented by 16 articles. Among 10 randomized studies, there was a significant reduction in SSI rate of 51% from 9.7% to 4.8% with NPWT intervention (RR 0.49 [95% CI 0.34–0.69] p < 0.0001). There were six observational studies assessing reduction in SSI rate of 67% from 22.5% to 7.4% with NPWT (RR 0. 32 [95% CI 0.18–0.55] p < 0.0001). Combining all 16 studies, there was a significant reduction in SSI of 58% from 12.5% to 5.2% with NPWT (RR 0.43 [95% CI 0.32–0.57] p < 0.0001). Similar effects were seen irrespective of the kind of surgery (orthopedic, abdominal, colorectal, or cesarean section), although the numbers needed to treat (NNT) were lower in operations with higher frequencies of complications. There was a significant reduction in dehiscence from 17.4% to 12.8% with NPWT (RR 0.71 [95% CI 0.54–0.92] p < 0.01). The mean reduction in hospital LOS by NPWT was also significant (−0.47 days [95% CI −0.71 to −0.23] p < 0.0001). Conclusions: The significant reduction in SSI, wound dehiscence, and LOS on the basis of pooled data from 16 studies shows a benefit of the PICO single-use NPWT system compared with standard care in closed surgical incisions.
Numerical Experiments on Matching Vacuum Transmission Lines to Loads

To efficiently connect a high-current-density load to a magnetically insulated vacuum transmission line, we require that the regularity of the electron flow be conserved. Regularity, i.e., Brillouin flow, can be preserved by keeping the invariants of the motion constant along the flow and requiring that small changes in these be adiabatic. It is shown that by matching the vacuum impedances of the various transmission line sections and assuring smooth transition between them, Brillouin flow of sheath electrons continues almost unperturbed to the load without losses. This idea is numerically demonstrated for a new type of diode which we name Brillouin diode.
Realization of a Piezophototronic Device Based on Reduced Graphene Oxide/MoS2 Heterostructure

In this letter, we present a piezophototronic device based on reduced graphene oxide (rGO)/MoS2 heterostructure on a flexible substrate. Here, we benefit from the semiconducting and piezoelectric behaviors of MoS2 sheets, besides the 2-D properties of rGO sheets. To elaborate the piezophototronic behavior, first, we have studied the stress-induced and optoelectronic behaviors separately. It is shown that the rGO sheets play a dominant role in stress-induced variations of the electrical behavior of rGO/MoS2bplay a dominant role in stress-induced variations of the electrical behavior of rGO/MoSased device. On the other hand, utilizing MoS2 sheets results in increasing the photoresponsivity of rGO/MoS2-based photodetector by a factor of about 2.1, comparing with rGO-based device (at λ = 450 nm). Finally, the investigated piezophototronic behavior of the realized rGO/MoS2-based device proves a responsivity enhancement of ~97%, by applying illumination and alternative strain (0.03%) simultaneously. The observed responsivity enhancement is attributed to the stress-induced piezopotential in MoS2 sheets, and the modulation of the Schottky barrier at rGO/MoS2 interface. The achieved results open up promising horizons for the coupling superior properties of MoS2 sheets, to realize new generation of high performance optoelectronic devices.
Phenotypic characterization of skin-infiltrating T cells in cutaneous T-cell lymphoma: comparison with benign cutaneous T-cell infiltrates.

Using a panel of monoclonal antibodies, we have studied cell surface antigens of infiltrating mononuclear cells in skin biopsies from patients with cutaneous T-cell lymphoma (CTCL) and compared them with the T-cell surface phenotype seen in benign cutaneous T-cell infiltrations (e.g., contact dermatitis, delayed hypersensitivity skin tests, granuloma annulare) and in dermal infiltrates of lymphomatoid granulomatosis patients. We found that unlike circulating CTCL (Sézary) cells, CTCL cells infiltrating skin epidermis frequently expressed the T-cell antigen 3A1. Cutaneous infiltrates in 10 patients with mycosis fungoides (MF) and 1 patient with Sézary syndrome were OKT4 (inducer T cell), OKT8 (suppressor/cytotoxic T cell); 2 patients with MF were OKT4-, OKT8; and one MF patients's skin T cell were OKT4-, OKT8+. Similar to CTCL infiltrating cells, most of the benign skin T-cell infiltrates were usually 3A1+. OKT4+, and OKT8-. Our study shows the complex nature of T-cell antigen patterns in inflammatory and malignant skin T-cell infiltrations. We demonstrated that the CTCL the skin epidermal infiltrating T-cell phenotype is not invariate, and in many cases, is similar to the phenotype of clinically benign cutaneous T-cell infiltrations.
Reduced arterial stiffness may contribute to angiotensin-converting enzyme inhibitor induced improvements in walking time in peripheral arterial disease patients

Objective Claudication is a debilitating consequence of peripheral arterial disease. Evidence is accumulating to suggest that large artery stiffness may influence peripheral perfusion and walking time through effects on peripheral hemodynamics as well as microvascular structure and function. We have previously shown that the angiotensin-converting enzyme inhibitor ramipril increased systemic arterial compliance by 64%, and increased maximum walking time by over 200% in patients with peripheral arterial disease. In the current analysis in the same patient cohort, we hypothesized that this relationship may, in part, be causal. Methods Forty patients with peripheral arterial disease [66 ± 4 years (mean ± SD); n = 20 per group] were randomized to ramipril, 10 mg once daily, or placebo for 24 weeks in a double-blind study. Maximum walking time was recorded during a standard treadmill test. Indices of arterial stiffness were assessed globally by systemic arterial compliance and augmentation index and regionally via central pulse wave velocity. Results Ramipril increased maximum walking time by 243% and improved arterial stiffness parameters by between 17 and 64% (all P < 0.001 compared with placebo). There were moderately strong correlations between the pre/post intervention change in maximum walking time and the change in indices of arterial stiffness (systemic arterial compliance, r = 0.65, P < 0.001; central pulse wave velocity, r = −0.57, P < 0.001; augmentation index, r = −0.79, P < 0.001; time to pressure augmentation, r = 0.52, P = 0.001). Conclusion The present data support the hypothesis that the beneficial effects of ramipril on maximum walking time observed in our peripheral arterial disease population are, at least partly, a consequence of reduced arterial stiffness.