Miracle-dz/UniFAR-FTUs huggingface dataset:
Fatigue and quality of life outcomes of exercise during cancer treatment.

PURPOSE Despite the recognition of fatigue as a common and distressing symptom during cancer treatment, there are few evidence-based interventions available to manage such fatigue. The purpose of this multi-institutional pilot study was to explore the effects of a home-based moderate walking exercise intervention on fatigue, physical functioning, emotional distress, and quality of life (QOL) during breast cancer treatment. DESCRIPTION OF STUDY Fifty-two women were recruited from five university hospital outpatient departments for this pilot study with an experimental design. Subjects were randomly assigned to the walking program or to usual care during adjuvant chemotherapy or radiation therapy for breast cancer. Symptoms, physical functioning, and QOL were measured at baseline, midtreatment, and at the end of treatment. RESULTS Women who exercised at least 90 minutes per week on 3 or more days reported significantly less fatigue and emotional distress as well as higher functional ability and QOL than women who were less active during treatment. CLINICAL IMPLICATIONS A home-based walking exercise program is a potentially effective, low-cost, and safe intervention to manage fatigue and to improve QOL during adjuvant chemotherapy or radiation therapy for breast cancer. This health-promoting self-care activity needs further testing in large randomized clinical trials.
Effect of Repetitive Transcranial Magnetic Stimulation on Malignant Visceral Pain

Background and objectives. To assess the efficacy of 10 sessions (once daily for 10 days) of repetitive transcranial magnetic stimulation (rTMS) on primary motor cortex (M1) in patients suffering from malignant visceral pain. Materials and methods. Thirty four patients were included in the study. They were divided randomly into two groups (17 patients for each, using closed envelopes): real rTMS (20 Hz, 10 trains with intertrain interval of 30 s with total pulses 2,000, intensity 80% of motor threshold) and sham rTMS (coil elevated and angled away from the head). Stimulation was applied over M1 every day for ten consecutive days. Patients were evaluated using a verbal descriptor scale (VDS), visual analog scale (VAS), and Hamilton rating scale for depression (HAM-D) at baseline; after the 1st, 5th, and 10th sessions; and then at 15 days and one month later after the end of the treatment sessions. Serum human dynorphin (Dyn) was measured at baseline, and after the 5th and 10th sessions. Results. Fifteen patients from each group completed the study. There was no significant difference between real and sham groups in the duration of illness, or any rating scales at baseline. Compared with the sham group, the VAS/VDS scores decreased more in patients who received real rTMS over the course of the treatment and at 15 days follow-up than in those who received sham stimulation. Scores were the same at one month follow-up. There were no significant changes in serum human Dyn in either group. Conclusion. The results confirm that 10 sessions of rTMS over the M1 can induce pain relief in malignant visceral pain for at least 15 days but the effect is not maintained at one month.
ADAPTACIÓN AL CASTELLANO DE UN INSTRUMENTO PARA EVALUAR EL ESTILO RUMIATIVO: LA ESCALA DE RESPUESTAS RUMIATIVAS

Resumen: En este trabajo se presenta la adaptacion al castellano de la Escala de Respuestas Rumiativas (RRS, Ruminative Responses Scale). Esta escala evalua la presencia del estilo de respuesta rumiativo, un patron de respuesta que consiste en una excesiva focalizacion en las causas y consecuencias de los sintomas depresivos. El estilo rumiativo ha sido asociado a una mayor probabilidad de desarrollar sintomatologia depresiva y ansiosa. En este trabajo se presenta la adaptacion al castellano de esta escala y datos sobre su consistencia interna, fiabilidad test-retest, validez factorial, validez convergente y validez incremental. El analisis factorial detecto dos factores, Reflexion y Reproches, replicando lo encontrado en estudios previos. La fiabilidad test-retest fue adecuada, y la consistencia interna fue incluso superior a lo encontrado en la escala original. Finalmente, la Escala de Respuestas Rumiativas fue un predictor significativo de la sintomatologia depresiva y ansiosa incluso tras controlar la influencia de Neuroticismo y Extraversion. Palabras clave: estilo rumiativo, rumiacion, depresion, medida, evaluacion, escala. Spanish adaptation of an instrument to assess ruminative style: ruminative responses scale
REGULATION OF ANTIBODY FORMATION BY SERUM ANTIBODY

In an earlier study from this laboratory (1), it was shown that serum antibody could be removed specifically from immunized animals by exposing their plasma to an immunoadsorbent and returning the adsorbed plasma to them. 1 or 2 days after the removal, serum antibody levels began to rise, reaching a peak 5 days later. The question of whether antigen released from the immunoadsorbent and returned to the circulation of the animal was responsible for the response was considered. Evidence was obtained that only trace amounts of antigen were released from the immunoadsorbent and that these amounts were insufficient to account for the response. Because of the critical nature of this question, however, we have attempted to remove antibody from immunized animals under circumstances in which reexposure to exogenous antigen could not occur. In addition, it was planned to study, by passive antibody administration, the extent to which redistribution of extravascular antibody affects the rise in levels of serum antibody after its removal. The experimental approach used was to immunize rabbits to two antigens and later to exchange their blood with that of rabbits immunized to only one of the antigens. In this way, antibody levels to one antigen were maintained, whereas antibody levels to the second antigen were markedly reduced. The results confirm and extend those previously reported: Following removal of antibody, specific antibody levels began to rise and in every case reached levels above those present before the exchange. In contrast, only a small increase in antibody levels was observed when antibody was passively administered before exchange.
Cutaneous Manifestations of Non-Celiac Gluten Sensitivity: Clinical Histological and Immunopathological Features

Background: The dermatological manifestations associated with intestinal diseases are becoming more frequent, especially now when new clinical entities, such as Non-Celiac Gluten Sensitivity (NCGS), are identified. The existence of this new entity is still debated. However, many patients with diagnosed NCGS that present intestinal manifestations have skin lesions that need appropriate characterization. Methods: We involved 17 patients affected by NCGS with non-specific cutaneous manifestations who got much better after a gluten free diet. For a histopathological and immunopathological evaluation, two skin samples from each patient and their clinical data were collected. Results: The median age of the 17 enrolled patients affected by NCGS was 36 years and 76% of them were females. On the extensor surfaces of upper and lower limbs in particular, they all presented very itchy dermatological manifestations morphologically similar to eczema, psoriasis or dermatitis herpetiformis. This similarity was also confirmed histologically, but the immunopathological analysis showed the prevalence of deposits of C3 along the dermo-epidermal junction with a microgranular/granular pattern (82%). Conclusions: The exact characterization of new clinical entities such as Cutaneous Gluten Sensitivity and NCGS is an important objective both for diagnostic and therapeutic purposes, since these are patients who actually benefit from a GFD (Gluten Free Diet) and who do not adopt it only for fashion.
Interprofessional initiatives at the University of Washington.

Pharmacists must collaborate with other health professionals to promote the optimal use of medications, relying on coordinated, interprofessional communication and care to do so. In 2003, the Institute of Medicine (IOM) recommended "all health professionals should be educated to deliver patient-centered care as members of an interdisciplinary team, emphasizing evidence-based practice, quality improvement approaches, and informatics. " At the University of Washington, the Center for Health Sciences Interprofessional Education (CHSIE) was established in 1997 to promote interprofessional curricular and clinical innovation in education, faculty development, and student activities, and to conduct evaluative research regarding the impact of interprofessional innovations. In this manuscript, we will describe the Center for Health Sciences Interprofessional Education, and highlight key projects that serve as examples of pharmacy involvement in interprofessional education, research, and service.
A Scalable Successive-Cancellation Decoder for Polar Codes

Polar codes are the first error-correcting codes to provably achieve channel capacity, asymptotically in code length, with an explicit construction. However, under successive-cancellation decoding, polar codes require very long code lengths to compete with existing modern codes. Nonetheless, the successive cancellation algorithm enables very-low-complexity implementations in hardware, due to the regular structure exhibited by polar codes. In this paper, we present an improved architecture for successive-cancellation decoding of polar codes, making use of a novel semi-parallel, encoder-based partial-sum computation module. We also provide quantization results for realistic code length N=215, and explore various optimization techniques such as a chained processing element and a variable quantization scheme. This design is shown to scale to code lengths of up to N=221, enabled by its low logic use, low register use and simple datapaths, limited almost exclusively by the amount of available SRAM. It also supports an overlapped loading of frames, allowing full-throughput decoding with a single set of input buffers.
Design and implementation of compressive samplers

The area of compressed sensing has developed a lot and is of high interest in the last few years because it provides a solid and promising method to exactly recover signals by sampling at very low rate compared to traditional rates. It has been proved that the topic can be applied to almost all signal processing area which deals with sparse signals. But most of the works done in compressed sensing is in digital domain. Very few works have been done in design of compressed sensing hardware based on analog compressed sensing. This paper aims to investigate the scope for designing an analog frontend for sampler which takes samples at sub-Nyquist rate. It is based on analog compressed sensing and is implemented using minimum electronic components.
Association of non-alcoholic fatty liver disease and cardiometabolic risk factors with early atherosclerosis in an adult population in Southern Italy.

AIM The prevalence of risk factors for cardiovascular and metabolic diseases was investigated in an adult population of the city of Cittanova, Southern Italy. METHODS The study was conducted among 992 randomly selected adults aged 18-75 years, between April 2009 and January 2011. RESULTS Prevalence rates of non-alcoholic fatty liver disease (NAFLD), overweight, obesity, and metabolic syndrome (MS) were 24.8%, 41.5%, 27.1%, and 34.4%, respectively. For the components of MS, prevalence of central obesity was 47.4%, impaired fasting glucose (IFG) 34.7%; hypertension 53.7%, low high-density lipoprotein (HDL) cholesterol 34.2%, and hypertriglyceridemia 27.2%. CONCLUSIONS Hypertension, central obesity, IFG, low HDL cholesterol, hypertriglyceridemia, MS, and increased carotid artery intima-media thickness (IMT) were significantly associated with NAFLD after adjustment for age and sex. With additional adjustment for body mass index (BMI), IMT and MS (depending on the prevalence ratio that was investigated), the positive association between the NAFLD and increased IMT lost statistical significance, while that with body mass index (BMI) and MS remained significant.
3D reconstruction from image collections with a single known focal length

In this paper we aim at reconstructing 3D scenes from images with unknown focal lengths downloaded from photosharing websites such as Flickr. First we provide a minimal solution to finding the relative pose between a completely calibrated camera and a camera with an unknown focal length given six point correspondences. We show that this problem has up to nine solutions in general and present two efficient solvers to the problem. They are based on Gröbner basis, resp. on generalized eigenvalues, computation. We demonstrate by experiments with synthetic and real data that both solvers are correct, fast, numerically stable and work well even in some situations when the classical 6-point algorithm fails, e.g. when optical axes of the cameras are parallel or intersecting. Based on this solution we present a new efficient method for large-scale structure from motion from unordered data sets downloaded from the Internet. We show that this method can be effectively used to reconstruct 3D scenes from collection of images with very few (in principle single) images with known focal lengths 1.
2D sub-optimum filters for sharpening interpolated satellite images by optimizing the structural similarity index measure

This paper deals with the design and analysis of 2D filters for improving the resolution of interpolated satellite images. The images are reduced first by a certain factor and then interpolated back to the original size. Linear phase 2D filters are designed to optimize the structural similarity index measure (SSIM). Then the satellite image is enlarged by the same factor and the 2D filter is used to sharpen the image. The performance of the new sub-optimum filters was assessed by using the peak signal to noise ratio (PSNR) and the SSIM on a variety of satellite images. It has been found that this method yields better results than optimizing the mean square error (MSE) or by using the sparse method.
Gene expression pattern Characterization of avian frizzled genes in cranial placode development

To determine the possible role of Wnt signaling in cranial placode development, we have cloned several chick frizzled genes, a family of putative Wnt receptor molecules, and analyzed their expression during chick embryogenesis. Chick frizzled-2 (cFz-2) and frizzled-7 (cFz-7) are expressed broadly in cranial ectoderm, tissue that is competent to express markers of the trigeminal placode (Stark et al., 1997. Development 124, 4287‐4295; Baker et al., 1999. Development 126, 147‐156). In addition, cFz-2 and cFz-7 are uniquely expressed in other cranial placodes, including the olfactory, lens, and otic placodes. Chick frizzled-1 (cFz-1) is expressed in the lens, otic placode and, along with cFz-7, in epibranchial placodes. Each frizzled gene expressed in the otic placode displays a unique domain of expression: cFz-1 transcripts are detected in the medial wall of the vesicle, cFz-2 in the rostral rim of the vesicle, and cFz-7 in the lateral half of the vesicle. Other chick frizzled family members cloned that do not show striking expression in cranial placodes include frizzled-4 (cFz-4), frizzled-8 (cFz-8), frizzled-9 (cFz-9), and frizzled-10 (cFz-10). A brief summary of their expression is given, along with a brief summary of nonplacodal expression of cFz-1, cFz-2, and cFz-7. In all, frizzled genes show dynamic expression at key times during embryonic development, particularly in the cranial placodes. q 2000 Elsevier Science Ireland Ltd. All rights reserved.
Defect Detection for Executable Specifications - An Experiment

The deployment of executable specifications has increased significantly in the last few years. Just as with any other specification documents, these specifications must be examined to ensure the necessary degree of quality. A common and successful technique used for examining traditional specifications is inspection. Now the question has arisen whether inspections on executable specification are the best choice, or if other techniques which use the execution capabilities of the models perform better. In this paper, we empirically compare several defect detection techniques for executable specifications. In particular, we examine inspections, testing, and ad-hoc simulation. Here, we use the specification languages Statemate and Matlab/Simulink. Also, we take a closer look at the inspection process itself and try to quantify the benefits of an inspection meeting for executable specifications.
Children of low‐income depressed mothers: psychiatric disorders and social adjustment

Background: Although several studies have documented a higher prevalence of psychiatric disorders in children of depressed than nondepressed parents, previous research was conducted in predominantly White, middle, or upper‐middle class populations. Only limited information is available on psychiatric disorders and psychosocial functioning in children of low‐income depressed mothers. Methods: We report the findings in children of mothers with and without a lifetime history of major depressive disorder, who were recruited from a large urban primary‐care practice. Bilingual clinical interviewers assessed 58 children with structured diagnostic interviews administered to most children (90%) and to their mothers as informants. Diagnostic assessments and best estimate diagnoses of the children were blind to the mothers' diagnostic status. Results: The families were poor and predominantly Hispanic, more than half of them headed by single mothers. After adjusting for child age and gender, and for any possible sibling correlation, children of depressed mothers had significantly higher rates of lifetime depressive, separation anxiety, oppositional defiant, and any psychiatric disorders than children of control mothers, with a lifetime prevalence of any psychiatric disorder of 84.6 versus 50.0%, respectively. Children of depressed mothers also reported significantly lower psychosocial functioning and had higher rates of psychiatric treatment. Conclusions: We conclude that the risk for psychiatric disorders may be particularly high in children of low‐income depressed mothers. The primary‐care setting offers a unique opportunity for early intervention with this underserved group. Depression and Anxiety, 2009. © 2008 Wiley‐Liss, Inc.
Identifying choreographic knowledge: choreographic techne and phronesis

Abstract This paper presents the core findings of a doctoral study conducted between 2009 and 2013 on teaching and learning the creative process in dance composition. Choreographic knowledge that enhances the technical and creative aspects of choreography is examined and interpreted on the basis of Aristotle’s techne and phronesis. The research tracks 10 professional choreographers, of whom 5 were selected from Korea and the remaining 5 from the United States, using qualitative research methods through the phenomenological approach. Choreographic knowledge identified through the components of choreographic techne and phronesis is clarified in three dimensions: choreography in form, choreography in context and choreography as metaphor. The study culminates with suggestions for further research and for practical implementation.
Enhanced photovoltaic properties in graphene/polycrystalline BiFeO3/Pt heterojunction structure

We report the enhanced photovoltaic properties in polycrystalline BiFeO3 (BFO) thin films with graphene as top electrodes. The short circuit current density (Jsc) and open circuit voltage of the heterojunction are measured to be 25 μA/cm2 and 0.44 V, respectively, much higher than the reported values for polycrystalline BFO with indium tin oxide (ITO) as top electrodes. Influence of HNO3 treatment on the photovoltaic properties is studied, and a significant photocurrent density improvement from 25 μA/cm2 to 2.8 mA/cm2 is observed. A metal-intrinsic semiconductor-metal model is proposed to explain the graphene induced enhancement comparing with traditional ITO.
Insulin Stimulated-Glucose Transporter Glut 4 Is Expressed in the Retina

The vertebrate retina is a very metabolically active tissue whose energy demands are normally met through the uptake of glucose and oxygen. Glucose metabolism in this tissue relies upon adequate glucose delivery from the systemic circulation. Therefore, glucose transport depends on the expression of glucose transporters. Here, we show retinal expression of the Glut 4 glucose transporter in frog and rat retinas. Immunohistochemistry and in situ hybridization studies showed Glut 4 expression in the three nuclear layers of the retina: the photoreceptor, inner nuclear and ganglionar cell layers. In the rat retina immunoprecipitation and Western blot analysis revealed a protein with an apparent molecular mass of 45 kDa. 14C-glucose accumulation by isolated rat retinas was significantly enhanced by physiological concentrations of insulin, an effect blocked by inhibitors of phosphatidyl-inositol 3-kinase (PI3K), a key enzyme in the insulin-signaling pathway in other tissues. Also, we observed an increase in 3H-cytochalasin binding sites in the presence of insulin, suggesting an increase in transporter recruitment at the cell surface. Besides, insulin induced phosphorylation of Akt, an effect also blocked by PI3K inhibition. Expression of Glut 4 was not modified in retinas of a type 1 diabetic rat model. To our knowledge, our results provide the first evidence of Glut4 expression in the retina, suggesting it as an insulin- responsive tissue.
Compositional characteristics of materials recovered from headed gutted silver carp (Hypophthalmichthys molitrix) by isoelectric solubilization and precipitation using organic acids.

UNLABELLED Protein was recovered from headed gutted silver carp by isoelectric solubilization at pH 2.5, 3.0, 11.5, or 12.0 and precipitation (ISP) at pH 5.5 using acetic (AA) or a 30% formic and lactic acid combination (F&L) and 10 N sodium hydroxide. Total protein and fat recovery yields, proximate composition and mineral analyses of fractions were determined. Protein and lipid recovery yields when solubilized under basic conditions were comparable to yields reported from other studies using hydrochloric acid; however, the recovered fractions were less pure. Processing at basic pH using AA was more effective than F&L at removing impurities (P < 0.05) from the recovered protein fraction and impurities were effectively removed from recovered lipids regardless of processing pH or acid type (P > 0.05). For the most part, sodium was greater (P < 0.05) and there was less calcium, phosphorus, magnesium, and iron (P < 0.05) in the recovered protein regardless of acid used when compared to the initial paste. This research shows that organic acids have the potential to recover protein and lipid by ISP processing. PRACTICAL APPLICATION This research presents a reliable method for extracting nutritionally valuable fish protein and oils from otherwise hard to process fish and its byproducts. Replacing the traditionally used strong acids with organic acids might further accomplish bacterial load reduction while resulting in similar to or improved protein recovery yields. Therefore, this technology may increase the commercial viability of hard to process fish.