Miracle-dz/UniFAR-FTUs huggingface dataset:
Camp stability predicts patterns of hunter–gatherer cooperation

Humans regularly cooperate with non-kin, which has been theorized to require reciprocity between repeatedly interacting and trusting individuals. However, the role of repeated interactions has not previously been demonstrated in explaining real-world patterns of hunter–gatherer cooperation. Here we explore cooperation among the Agta, a population of Filipino hunter–gatherers, using data from both actual resource transfers and two experimental games across multiple camps. Patterns of cooperation vary greatly between camps and depend on socio-ecological context. Stable camps (with fewer changes in membership over time) were associated with greater reciprocal sharing, indicating that an increased likelihood of future interactions facilitates reciprocity. This is the first study reporting an association between reciprocal cooperation and hunter–gatherer band stability. Under conditions of low camp stability individuals still acquire resources from others, but do so via demand sharing (taking from others), rather than based on reciprocal considerations. Hunter–gatherer cooperation may either be characterized as reciprocity or demand sharing depending on socio-ecological conditions.
Associations between the number of natural teeth and metabolic syndrome in adults.

AIM To explore associations between the number of natural teeth and metabolic syndrome in adults. MATERIAL AND METHODS Cross-sectional data from the National Health and Nutrition Examination Survey 2005-2008 were used. Eligible adults (n = 5511) were classified into four groups by their number of natural teeth (excluding third molars): full dentition, 21-27 teeth, 1-20 teeth, or edentulous. Metabolic syndrome was defined by diagnostic guidelines from the American Heart Association and National Heart, Lung, and Blood Institute. Associations were analysed by survey logistic regression. Biometric and metabolic parameters in different dentition groups were compared. RESULTS Adjusting for age, gender, race/ethnicity, ratio of family income to poverty, physical activity, smoking, and energy intake, tooth loss was significantly associated with metabolic syndrome (p = 0.002). Compared to participants with full dentition, the odds were 32% higher in those with 21-27 teeth, 55% higher in those with 1-20 teeth and 79% higher in edentulous participants. The number of natural teeth was inversely associated with body mass index, waist circumference, blood pressure, fasting plasma glucose and insulin concentrations (p < 0.01 for all); it was positively associated with serum HDL cholesterol concentration (p = 0.003). CONCLUSIONS The number of natural teeth is inversely associated with the presence of metabolic syndrome in adults.
Native Tertiary Structure and Nucleoside Modifications Suppress tRNA’s Intrinsic Ability to Activate the Innate Immune Sensor PKR

Interferon inducible protein kinase PKR is an essential component of innate immunity. It is activated by long stretches of dsRNA and provides the first line of host defense against pathogens by inhibiting translation initiation in the infected cell. Many cellular and viral transcripts contain nucleoside modifications and/or tertiary structure that could affect PKR activation. We have previously demonstrated that a 5′-end triphosphate–a signature of certain viral and bacterial transcripts–confers the ability of relatively unstructured model RNA transcripts to activate PKR to inhibit translation, and that this activation is abrogated by certain modifications present in cellular RNAs. In order to understand the biological implications of native RNA tertiary structure and nucleoside modifications on PKR activation, we study here the heavily modified cellular tRNAs and the unmodified or the lightly modified mitochondrial tRNAs (mt-tRNA). We find that both a T7 transcript of yeast tRNAPhe and natively extracted total bovine liver mt-tRNA activate PKR in vitro, whereas native E. coli, bovine liver, yeast, and wheat tRNAPhe do not, nor do a variety of base- or sugar-modified T7 transcripts. These results are further supported by activation of PKR by a natively folded T7 transcript of tRNAPhe in vivo supporting the importance of tRNA modification in suppressing PKR activation in cells. We also examine PKR activation by a T7 transcript of the A14G pathogenic mutant of mt-tRNALeu, which is known to dimerize, and find that the misfolded dimeric form activates PKR in vitro while the monomeric form does not. Overall, the in vitro and in vivo findings herein indicate that tRNAs have an intrinsic ability to activate PKR and that nucleoside modifications and native RNA tertiary folding may function, at least in part, to suppress such activation, thus serving to distinguish self and non-self tRNA in innate immunity.
An event-related fMRI study of visual and auditory oddball tasks

Used whole brain event-related functional magnetic resonance imaging (fMRI) techniques to elucidate the cerebral sites involved in processing rare target and novel visual stimuli during an oddball discrimination task in 10 Ss (mean age 25.4 yrs). Analyses of hemodynamic response to the visual target stimuli revealed a distributed network of neural sources in anterior and posterior cingulate, inferior and middle frontal gyrus, bilateral parietal lobules, anterior superior temporal gyrus, amygdala, and thalamus. The analyses of the hemodynamic response for the visual novel stimuli revealed an extensive network of neural activations in occipital lobes and posterior temporal lobes, bilateral parietal lobules, and lateral frontal cortex. The hemodynamic response associated with processing target and novel stimuli in the visual modality were also compared with data from an analogous study in the auditory modality (K. A. Kiehl et al., 2001). The results support the hypothesis that target detection and novelty processing are associated with neural activation in widespread neural areas, suggesting that the brain seems to adopt a strategy of activating many potentially useful brain regions despite the low probability that these brain regions are necessary for task performance.
Object retrieval with large vocabularies and fast spatial matching

In this paper, we present a large-scale object retrieval system. The user supplies a query object by selecting a region of a query image, and the system returns a ranked list of images that contain the same object, retrieved from a large corpus. We demonstrate the scalability and performance of our system on a dataset of over 1 million images crawled from the photo-sharing site, Flickr [3], using Oxford landmarks as queries. Building an image-feature vocabulary is a major time and performance bottleneck, due to the size of our dataset. To address this problem we compare different scalable methods for building a vocabulary and introduce a novel quantization method based on randomized trees which we show outperforms the current state-of-the-art on an extensive ground-truth. Our experiments show that the quantization has a major effect on retrieval quality. To further improve query performance, we add an efficient spatial verification stage to re-rank the results returned from our bag-of-words model and show that this consistently improves search quality, though by less of a margin when the visual vocabulary is large. We view this work as a promising step towards much larger, "web-scale " image corpora.
A Critical Period for Social Experience–Dependent Oligodendrocyte Maturation and Myelination

A Critical Period for Glia The brain develops in fits and starts—while one system is completed, another system may still be under construction. Such transient states are known as critical periods, and during these specific aspects of brain development may become more sensitive to outside agents than they would be later. Makinodan et al. (p. 1357) observed the effect of environmental conditions on the brains of mice bioengineered to develop fluorescent oligodendrocytes. The mice were exposed to a variety of social conditions during rearing, ranging from isolation to a normal laboratory cage setting, or to settings enriched with extra buddies and a steady rotation of new play toys. The results show that social isolation leaves a developmental trace that persists into adulthood. Specifically, they found that oligodendrocytes, which produce the myelin that insulates neurons, were underdeveloped, suggesting that there may be a critical period that governs development of these glial oligodendrocyte cells. In mice, early social experience regulates prefrontal cortex myelination that is essential for normal cognitive development. Early social isolation results in adult behavioral and cognitive dysfunction that correlates with white matter alterations. However, how social deprivation influences myelination and the significance of these myelin defects in the adult remained undefined. We show that mice isolated for 2 weeks immediately after weaning have alterations in prefrontal cortex function and myelination that do not recover with reintroduction into a social environment. These alterations, which occur only during this critical period, are phenocopied by loss of oligodendrocyte ErbB3 receptors, and social isolation leads to reduced expression of the ErbB3 ligand neuregulin-1. These findings indicate that social experience regulates prefrontal cortex myelination through neuregulin-1/ErbB3 signaling and that this is essential for normal cognitive function, thus providing a cellular and molecular context to understand the consequences of social isolation.
INFLUENCE OF ATTENTIONAL AND MOTIVATIONAL FACTORS ON THE PERFORMANCE OF A MASTERED MOTOR TASK

of Thesis Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Master of Science in Exercise and Sport Sciences INFLUENCE OF ATTENTIONAL AND MOTIVATIONAL FACTORS ON THE PERFORMANCE OF A MASTERED MOTOR TASK By Christopher K. Wirth August 2004 Chair: John R.Todorovich Major Department: Exercise and Sport Sciences The purpose of this study was to determine the influence of one’s achievement goal orientation on one’s reported attentional foci during the performance of a mastered motor task. Four hundred undergraduate university students completed the Task and Ego Orientation in Physical Activity Questionnaire. Two of the four orientation combinations were found in the population selected for the study. A total of 26 high task/high ego and 20 high task/low ego students participated in a two-foot balance task consisting of five, 20-second trials. The mean path length of the second, third, and fourth trial was compared for the two orientation groups. A t-test showed no differences in the performances of the two groups; t-obtained = . 54 (α = .05). Attentional foci of participants during the performance was obtained and analyzed. Statements from the high task/high ego group and high task/low ego group produced 12 and 11 categories, respectively. Three themes emerged for both groups: (1) performance influences, (2) research setting enigmas, and (3) concerns of self. While both groups used in the study
Exploring the Context of Locations for Personalized Location Recommendations

Conventional location recommendation models rely on users' visit history, geographical influence, temporal influence, etc., to infer users' preferences for locations. However, systematically modeling a location's context (i.e., the set of locations visited before or after this location) is relatively unexplored. In this paper, by leveraging the Skipgram model, we learn the latent representation for a location to capture the influence of its context. A pair-wise ranking loss that considers the confidences of observed user preferences for locations is then proposed to learn users' latent representations for personalized top-N location recommendations. Moreover, we also extend our model by taking into account temporal influence. Stochastic gradient descent based optimization algorithms are developed to fit the models. We conduct comprehensive experiments over four real datasets. Experimental results demonstrate that our approach significantly outperforms the state-of-the-art location recommendation methods.
Why Some Faces won't be Remembered: Brain Potentials Illuminate Successful Versus Unsuccessful Encoding for Same-Race and Other-Race Faces

Memory is often less accurate for faces from another racial group than for faces from one's own racial group. The mechanisms underlying this phenomenon are a topic of active debate. Contemporary theories invoke factors such as inferior expertise with faces from other racial groups and an encoding emphasis on race-specifying information. We investigated neural mechanisms of this memory bias by recording event-related potentials while participants attempted to memorize same-race (SR) and other-race (OR) faces. Brain potentials at encoding were compared as a function of successful versus unsuccessful recognition on a subsequent-memory test. Late positive amplitudes predicted subsequent memory for SR faces and, to a lesser extent, for OR faces. By contrast, the amplitudes of earlier frontocentral N200 potentials and occipito-temporal P2 potentials were larger for later-remembered relative to later-forgotten OR faces. Furthermore, N200 and P2 amplitudes were larger for OR faces with features considered atypical of that race relative to faces that were race-stereotypical (according to a consensus from a large group of other participants). In keeping with previous reports, we infer that these earlier potentials index the processing of unique or individuating facial information, which is key to remembering a face. Individuation may tend to be uniformly high for SR faces but lower and less reliable for OR faces. Individuation may also be more readily applied for OR faces that appear less stereotypical. These electrophysiological measures thus provide novel evidence that poorer memory for OR faces stems from encoding that is inadequate because it fails to emphasize individuating information.
The Four Dimensional Impact Of Color On Shoppers’ Emotions

The PAD-scale has extensively been used in consumer research. Since studies on the impact of store interior color on affective responses are scarce and focussed solely on color hue, neglecting color brightness and saturation, and furthermore only investigated a maximum of four hues, the research objective was to validate the PAD scale by means of an 8 (hue) by 2 (brightness) by 2 (saturation) experimental design. The data do not seem to underlie three, but four factors: pleasure, tension, excitement and dominance. Overall, the PAD-scores prove to have adequate reliability and validity, although the dominance construct is rather weak
Beyond contingency planning: towards a model of crisis management

This paper reviews the central contributions to the crisis management liter ature, addresses its various dimensions and details the major phases within which crises occur. The paper seeks to develop a schematic model for crises and concludes by advocating that management needs to acknowledge the lim itations of its contingency planning in order to allow for more effective deci sion making. The model suggests that there are three phases within a crisis: the precipitation phase in which the potential for a crisis is created, the operational phase of the crisis, and the post-crisis phase. The resultant model provides a framework for the subsequent analysis of crisis events.
INDIVIDUALISM, COLLECTIVISM AND TRUST

The starting point of the study is that collectivism has not received rightful attention from scholars. It has been speculated that individualism was associated with the increase of social trust, whereas collectivism has been linked with hierarchical and engulfed social bonds that impede the formation of trust in society. Bearing this in mind, patterns of general and particularized trust among Australian national public officers were explored in relation to cultural value orientations. To measure particularized trust, five sets of social relations, which are considered to be important for our social lives, were employed. According to the result, horizontal collectivism (i.e., HC) was positively associated both with general trust and particularized trust in all five sets of social relations; furthermore, these positive relationships were maintained even when the familiarity of trustees was controlled. Vertical collectivism (i.e., VC) mirrored HC in its relationships with patterns of trust in a lesser degree; that is to say, VC was positively related with general trust and particularized trust in people in a set of social relations. In contrast, horizontal and vertical individualism (i.e., HI and VI, respectively) was not significantly linked with general trust. As for particularized trust, VI was related with trust in the former schoolmates; however, this relationship was diminished when the familiarity of trustees was controlled. Theoretical implications of the study were discussed.
Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

We have constructed derivatives of Streptomyces coelicolor M145 as hosts for the heterologous expression of secondary metabolite gene clusters. To remove potentially competitive sinks of carbon and nitrogen, and to provide a host devoid of antibiotic activity, we deleted four endogenous secondary metabolite gene clusters from S. coelicolor M145 – those for actinorhodin, prodiginine, CPK and CDA biosynthesis. We then introduced point mutations into rpoB and rpsL to pleiotropically increase the level of secondary metabolite production. Introduction of the native actinorhodin gene cluster and of gene clusters for the heterologous production of chloramphenicol and congocidine revealed dramatic increases in antibiotic production compared with the parental strain. In addition to lacking antibacterial activity, the engineered strains possess relatively simple extracellular metabolite profiles. When combined with liquid chromatography and mass spectrometry, we believe that these genetically engineered strains will markedly facilitate the discovery of new compounds by heterologous expression of cloned gene clusters, particularly the numerous cryptic secondary metabolic gene clusters that are prevalent within actinomycete genome sequences.
Distributions of Cells and Neurons across the Cortical Sheet in Old World Macaques

According to previous research, cell and neuron densities vary across neocortex in a similar manner across primate taxa. Here, we provide a more extensive examination of this effect in macaque monkeys. We separated neocortex from the underlying white matter in 4 macaque monkey hemispheres (1 Macaca nemestrina, 2 Macaca radiata, and 1 Macaca mulatta), manually flattened the neocortex, and divided it into smaller tissue pieces for analysis. The number of cells and neurons were determined for each piece across the cortical sheet using flow cytometry. Primary visual cortex had the most densely packed neurons and primary motor cortex had the least densely packed neurons. With respect to differences in brain size between cases, there was little variability in the total cell and neuron numbers within specific areas, and overall trends were similar to what has been previously described in Old World baboons and other primates. The average hemispheric total cell number per hemisphere ranged from 2.9 to 3.7 billion, while the average total neuron number ranged from 1.3 to 1.7 billion neurons. The visual cortex neuron densities were predictably higher, ranging from 18.2 to 34.7 million neurons/cm2 in macaques, in comparison to a range of 9.3-17.7 million neurons/cm2 across cortex as a whole. The results support other evidence that neuron surface densities vary across the cortical sheet in a predictable pattern within and across primate taxa.
Interaction between the Human Mitochondrial Import Receptors Tom20 and Tom70 in Vitro Suggests a Chaperone Displacement Mechanism*

The mitochondrial import receptor Tom70 contains a tetratricopeptide repeat (TPR) clamp domain, which allows the receptor to interact with the molecular chaperones, Hsc70/Hsp70 and Hsp90. Preprotein recognition by Tom70, a critical step to initiate import, is dependent on these cytosolic chaperones. Preproteins are subsequently released from the receptor for translocation across the outer membrane, yet the mechanism of this step is unknown. Here, we report that Tom20 interacts with the TPR clamp domain of Tom70 via a conserved C-terminal DDVE motif. This interaction was observed by cross-linking endogenous proteins on the outer membrane of mitochondria from HeLa cells and in co-precipitation and NMR titrations with purified proteins. Upon mutation of the TPR clamp domain or deletion of the DDVE motif, the interaction was impaired. In co-precipitation experiments, the Tom20-Tom70 interaction was inhibited by C-terminal peptides from Tom20, as well as from Hsc70 and Hsp90. The Hsp90-Tom70 interaction was measured with surface plasmon resonance, and the same peptides inhibited the interaction. Thus, Tom20 competes with the chaperones for Tom70 binding. Interestingly, antibody blocking of Tom20 did not increase the efficiency of Tom70-dependent preprotein import; instead, it impaired the Tom70 import pathway in addition to the Tom20 pathway. The functional interaction between Tom20 and Tom70 may be required at a later step of the Tom70-mediated import, after chaperone docking. We suggest a novel model in which Tom20 binds Tom70 to facilitate preprotein release from the chaperones by competition.
Live wide-area migration of virtual machines including local persistent state

So far virtual machine (VM) migration has focused on transferring the run-time memory state of the VMs in local area networks (LAN). However, for wide-area network (WAN) migration it is crucial to not just transfer the VMs image but also transfer its local persistent state (its file system) and its on-going network connections. In this paper we address both: by combining a block-level solution with pre-copying and write throttling we show that we can transfer an entire running web server, including its local persistent state, with minimal disruption --- three seconds in the LAN and 68 seconds in the WAN); by combining dynDNS with tunneling, existing connections can continue transparently while new ones are redirected to the new network location. Thus we show experimentally that by combining well-known techniques in a novel manner we can provide system support for migrating virtual execution environments in the wide area.