Miracle-dz/UniFAR-FTUs huggingface dataset:
Environmental tobacco smoke and lung cancer in nonsmoking women.

To the Editor. —The ongoing multicenter study by Fontham et al 1 of lung cancer risk in nonsmoking women exposed to environmental tobacco smoke (ETS), which was updated in the June 8, 1994, issue of JAMA , is an impressive piece of work. The trend is clear: passive exposure to cigarette smoke is a risk. But I fear the authors dilute that point by incorporating too many tenuous variables in their statistical analyses. They acknowledge the problem of such factors as childhood recall of exposure and make attempts to control for it, but seem unwilling to admit that these and other data (eg, social exposure) are essentially not quantifiable by present methods. Inclusion of all these variables therefore led to a few implausible outcomes, which could give a window of solace to those who would defend ETS. The most implausible conclusion was that "[t]he excess risk of lung cancer among women
Physical Performance and Electromyographic Responses to an Acute Bout of Paired Set Strength Training Versus Traditional Strength Training

Robbins, DW, Young, WB, Behm, DG, Payne, WR, and Klimstra, MD. Physical performance and electromyographic responses to an acute bout of paired set strength training versus traditional strength training. J Strength Cond Res 24(5): 1237-1245, 2010-The objective of this study was to investigate the acute effects of performing paired set (PS) vs. traditional set (TS) training over 3 consecutive sets on volume load (VL) and electromyographic (EMG) activity of the pectoralis major, anterior deltoid, latissimus dorsi, and trapezius muscles. Following a familiarization session 16 trained males performed 2 testing protocols using 4 repetition maximum loads: TS (3 sets of bench pull [Bpull] followed by 3 sets of bench press [Bpress] performed in approximately 20 minutes) or PS (3 sets of Bpull and 3 sets of Bpress performed in an alternating manner in approximately 10 minutes). Bpull and Bpress VL decreased significantly from set 1 to set 2 and from set 2 to set 3 under both conditions. There was no difference between VL per set, or over the sessions, between the 2 conditions. PS was determined to be more efficient (VL/time) as compared to TS. EMG activity of the 4 monitored muscles was not different for the 2 conditions or within each condition over the 3 sets. However, there was a significant within-set response in EMG activity in the Bpress exercise. The data suggest that a 4-minute rest interval between sets may not be adequate to maintain VL using either protocol. The data further suggest that PS training may be as effective as TS training in terms of VL maintenance and more effective in terms of efficiency. The comparison of EMG activity between the PS and TS protocols suggests that the level of neuromuscular fatigue does not differ under the 2 conditions. PS training would appear to be an effective method of exercise with respect to VL maintenance and efficiency.
Variable Stars in the Unusual, Metal-rich Globular Cluster NGC 6388

We have undertaken a search for variable stars in the metal-rich globular cluster NGC 6388, using time-series BV photometry. Twenty-eight new variables were found in this survey, increasing the total number of variables found near NGC 6388 to ∼57. A significant number of the variables are RR Lyrae (∼14), most of which are probable cluster members. The periods of the fundamental-mode RR Lyrae are shown to be unusually long compared with metal-rich field stars. The existence of these long-period RRab stars suggests that the horizontal branch of NGC 6388 is unusually bright. This implies that the metallicity-luminosity relationship for RR Lyrae stars is not universal if the RR Lyrae in NGC 6388 are indeed metal-rich. We consider the alternative possibility that the stars in NGC 6388 may span a range in [Fe/H]. Four candidate Population II Cepheids were also found. If they are members of the cluster, NGC 6388 would be the most metal-rich globular cluster to contain Population II Cepheids. The mean V magnitude of the RR Lyrae is found to be 16.85 ± 0.05, resulting in a distance of 9.0 to 10.3 kpc for a range of assumed values of ⟨MV⟩ for RR Lyrae. We determine the reddening of the cluster to be E(B-V) = 0.40 ± 0.03 mag, with differential reddening across the face of the cluster. We discuss the difficulty in determining the Oosterhoff classification of NGC 6388 and NGC 6441 due to the unusual nature of their RR Lyrae and address evolutionary constraints on a recent suggestion that they are of Oosterhoff type II.
Genetic Structure and Distribution of Four Pathogenicity Islands (PAI I536 to PAI IV536) of Uropathogenic Escherichia coli Strain 536

ABSTRACT For the uropathogenic Escherichia coli strain 536 (O6:K15:H31), the DNA sequences of three pathogenicity islands (PAIs) (PAI I536 to PAI III536) and their flanking regions (about 270 kb) were determined to further characterize the virulence potential of this strain. PAI I536 to PAI III536 exhibit features typical of PAIs, such as (i) association with tRNA-encoding genes; (ii) G+C content differing from that of the host genome; (iii) flanking repeat structures; (iv) a mosaic-like structure comprising a multitude of functional, truncated, and nonfunctional putative open reading frames (ORFs) with known or unknown functions; and (v) the presence of many fragments of mobile genetic elements. PAI I536 to PAI III536 range between 68 and 102 kb in size. Although these islands contain several ORFs and known virulence determinants described for PAIs of other extraintestinal pathogenic E. coli (ExPEC) isolates, they also consist of as-yet-unidentified ORFs encoding putative virulence factors. The genetic structure of PAI IV536, which represents the core element of the so-called high-pathogenicity island encoding a siderophore system initially identified in pathogenic yersiniae, was further characterized by sample sequencing. For the first time, multiple PAI sequences (PAI I536 to PAI IV536) in uropathogenic E. coli were studied and their presence in several wild-type E. coli isolates was extensively investigated. The results obtained suggest that these PAIs or at least large fragments thereof are detectable in other pathogenic E. coli isolates. These results support our view that the acquisition of large DNA regions, such as PAIs, by horizontal gene transfer is an important factor for the evolution of bacterial pathogens.
Niche width revisited: organizational scope, behavior and performance

Although strategy research typically regards firm scope as a positional characteristic associated with performance differences, we propose that broad contemporary scope also provides insight into the routines that govern firm behavior. To attain broad scope, firms must repeatedly explore outside the boundaries of their current niche. Firms with broad niches therefore operate under a set of routines that repeatedly propel them into new market segments, expanding their niche. These niche expansions, however, involve risky organizational changes, behavior that disadvantages generalists relative to specialists, despite the positional value of broad scope. Empirical analyses of machine tool manufacturers and computer workstation manufacturers support this conjecture: (i) generalists introduce new products at a higher than optimal rate, thereby increasing their exit rates; and (ii) generalists also more frequently launch new models with novel features or targeted at new consumer segments rather than improving only incrementally on existing products, further accelerating their odds of failure. After adjusting for these behavioral differences, broad niche widths reduce exit rates, suggesting that they provide positional advantages. The paper discusses how this phenomenon may help to explain the diversification and multi-nationality discounts. Copyright © 2006 John Wiley & Sons, Ltd.
Endoscopic Mis-sizing of Polyps Changes Colorectal Cancer Surveillance Recommendations

BACKGROUND: Adenomatous polyps greater than 1 cm are defined as advanced adenomas. Inaccurate size estimation can lead to inappropriate surveillance recommendations of colorectal adenomas. OBJECTIVE: The aim of this study was to determine the impact of endoscopic polyp mis-sizing on colorectal cancer surveillance recommendations. DESIGN: This is a prospective study. SETTING: This study was conducted in a gastroenterology practice at a US academic medical center. PATIENTS: Patients undergoing colorectal cancer screening and surveillance colonoscopies from 2010 to 2011 were included. MAIN OUTCOME MEASUREMENTS: Endoscopic size estimates of polyps 10 to 25 mm were compared with postfixation histopathologic polyp measurements for 15 different gastroenterologists. Only adenomatous polyps removed in entirety by snare polypectomy were included in the analysis. Size variation was defined as (endoscopic estimate − histopathologic size)/(histopathologic size). Clinical mis-sizing was defined as a size variation of >33%. The mean size variation, the percentage of clinical mis-sizing, and the percentage of inappropriate surveillance recommendation due to size variation >33% were reported per endoscopist. RESULTS: Included for analysis were 4990 procedures from 15 gastroenterologists. A total of 230 polyps from 200 patients met inclusion criteria. The average age was 62.6 years (SD 10.1), and 52% were men. The mean size variation between the endoscopic polyp size estimation and the histopathologic polyp was 73.6% (range of mean size variation, 13%–127%). 62.6% (range, 0%–91%) of included polyps had clinical mis-sizing. Of included polypectomies, 35.2% (range, 0%–67%) resulted in an inappropriate surveillance recommendation due to clinical mis-sizing even after considering histology and synchronous polyps. LIMITATIONS: This was a single-center study. CONCLUSIONS: There is marked variation in endoscopists’ ability to accurately size adenomatous polyps. Some endoscopists rarely mis-size adenomas, and their surveillance recommendations are appropriate in regard to sizing. However, other endoscopists inaccurately size adenomas, and this leads to inappropriate surveillance of colorectal polyps. In this study, approximately 1 of 3 included polypectomies yielded inappropriate surveillance recommendations because of clinical mis-sizing.
Spectrum of Phosphatidylinositol 3-Kinase Pathway Gene Alterations in Bladder Cancer

Purpose: The phosphatidylinositol 3-kinase (PI3K) pathway can be activated by alterations affecting several pathway components. For rational application of targeted therapies, detailed understanding of tumor biology and approaches to predict efficacy in individual tumors are required. Our aim was to assess the frequency and distribution of pathway alterations in bladder cancer. Experimental Design: We examined the pathway components (PIK3CA, PTEN, TSC1, RHEB, and LKB1) and putative upstream regulators (FGFR3 and RAS genes) for mutation, allelic loss, copy number alteration, and expression in bladder tumors and cell lines. Results: No mutations were found in RHEB and only a single mutation in LKB1. PIK3CA mutations were detected in 25% of tumors and 26% of cell lines with a significant excess of helical domain mutations (E542K and E545K). There was over-representation but not amplification of the gene. Loss of heterozygosity of the PTEN region and homozygous deletion were found in 12% and 1.4% of tumors, and reduced expression in 49%. Forty-six percent of cell lines showed alterations that implicated PTEN. Sixteen percent of tumors and 11% of cell lines showed TSC1 mutation, and 9q loss of heterozygosity was common (57%). Pathway alterations were independently distributed, suggesting that the mutation of two pathway members may have additive or synergistic effects through noncanonical functions. Conclusions: PI3K pathway alterations are common in bladder cancer. The lack of redundancy of alterations suggests that single-agent PI3K-targeted therapy may not be successful in these cancers. This study provides a well-characterized series of cell lines for use in preclinical studies of targeted agents. (Clin Cancer Res 2009;15(19):6008–17)
The role of microtubule dynamics in growth cone motility and axonal growth

The growth cone contains dynamic and relatively stable microtubule populations, whose function in motility and axonal growth is uncharacterized. We have used vinblastine at low doses to inhibit microtubule dynamics without appreciable depolymerization to probe the role of these dynamics in growth cone behavior. At doses of vinblastine that interfere only with dynamics, the forward and persistent movement of the growth cone is inhibited and the growth cone wanders without appreciable forward translocation; it quickly resumes forward growth after the vinblastine is washed out. Direct visualization of fluorescently tagged microtubules in these neurons shows that in the absence of dynamic microtubules, the remaining mass of polymer does not invade the peripheral lamella and does not undergo the usual cycle of bundling and splaying and the growth cone stops forward movement. These experiments argue for a role for dynamic microtubules in allowing microtubule rearrangements in the growth cone. These rearrangements seem to be necessary for microtubule bundling, the subsequent coalescence of the cortex around the bundle to form new axon, and forward translocation of the growth cone.
A whole-farm investment analysis of some precision agriculture technologies

This study used information about a farm in the Victorian Mallee during the period 1998 â€“ 2005 to analyse the profitability of investing in Precision Agriculture and Site-Specific Crop Management technology and farming systems. Two equipment guidance systems were evaluated. Both guidance systems earned more than 8 percent real return p.a. on the extra capital invested. A Real-Time Kinetic (RTK) guidance system with a precision of 2 cm and a capital cost of $50,000 was less profitable than a Sub-Metre guidance system with 20 cm accuracy and costing $20,000. Producers investing in RTK guidance technology would be well-paid to also adopt supporting management practices that enhance crop gross margins or provide other benefits. The capital cost of GPS technology has to be spread over sufficient hectares. Investment in Zone Management technologies to fine-tune applications of nitrogen within paddocks did not meet the required return on capital of 8 percent p.a. With the spatial variability on this farm, 1670 hectares of crop were required for the investment to break-even with alternative uses of the capital. Alternatively, with 900 hectares cropped on this case study farm, spatial variation of at least 2.5 t/ha in yield across paddocks was required to justify the investment in the Zone Management technology.
Non-antibiotic Isotretinoin Treatment Differentially Controls Propionibacterium acnes on Skin of Acne Patients

Emergence and potential transfer of antibiotic resistance in skin microorganisms is of current concern in medicine especially in dermatology contexts where long term treatment with antibiotics is common. Remarkably, non-antibiotic therapy in the form of isotretinoin – a non-antimicrobial retinoid is effective at reducing or eradicating the anaerobe Propionibacterium acnes which is causally involved in the complex pathogenesis of Acne vulgaris. This study measured the extent of colonization of P. acnes in patients with primary cystic or severe acne from three defined skin sites in ‘non-lesion’ areas before, during and after treatment with isotretinoin. Patients attending acne clinics were investigated using standardized skin sampling techniques and the recovery of anaerobic P. acnes from 56 patients comprising 24 females and 32 males (mean age 22 years, age range 15–46 years) who were given a standard course of isotretinoin (1 mg/kg/day) are reported. P. acnes cultured from the external cheek surface of patients following treatment showed a significant reduction (1–2 orders of magnitude) compared with their pre-treatment status. Interestingly, other distinct sites (nares and toe web) failed to show this reduction. In addition, high levels of antibiotic-resistant P. acnes were recorded in each patients’ skin microbiota before, during and after treatment. In this study, microbial composition of the skin appears substantially altered by isotretinoin treatment, which clearly has differential antimicrobial effects on each anatomically distinct site. Our study confirmed that orally administered isotretinoin shows good efficacy in the resolution of moderate to severe acne that correlates with reductions in the number of P. acnes on the skin, including resistant isolates potentially acquired from previous treatments with antibiotics. Our study suggests that the role of tetracycline’s and macrolides, which are currently first line treatments in dermatology, might be reserved for severe or life-threatening infections since current antibiotic stewardship guidelines from medical departments no longer prescribe these antibiotics for routine use.
MicroRNA enrichment among short ‘ultraconserved’ sequences in insects

MicroRNAs are short (∼22 nt) regulatory RNA molecules that play key roles in metazoan development and have been implicated in human disease. First discovered in Caenorhabditis elegans, over 2500 microRNAs have been isolated in metazoans and plants; it has been estimated that there may be more than a thousand microRNA genes in the human genome alone. Motivated by the experimental observation of strong conservation of the microRNA let-7 among nearly all metazoans, we developed a novel methodology to characterize the class of such strongly conserved sequences: we identified a non-redundant set of all sequences 20 to 29 bases in length that are shared among three insects: fly, bee and mosquito. Among the few hundred sequences greater than 20 bases in length are close to 40% of the 78 confirmed fly microRNAs, along with other non-coding RNAs and coding sequence.
Cross-species fertilization: the hamster egg receptor, Juno, binds the human sperm ligand, Izumo1

Fertilization is the culminating event in sexual reproduction and requires the recognition and fusion of the haploid sperm and egg to form a new diploid organism. Specificity in these recognition events is one reason why sperm and eggs from different species are not normally compatible. One notable exception is the unusual ability of zona-free eggs from the Syrian golden hamster (Mesocricetus auratus) to recognize and fuse with human sperm, a phenomenon that has been exploited to assess sperm quality in assisted fertility treatments. Following our recent finding that the interaction between the sperm and egg recognition receptors Izumo1 and Juno is essential for fertilization, we now demonstrate concordance between the ability of Izumo1 and Juno from different species to interact, and the ability of their isolated gametes to cross-fertilize each other in vitro. In particular, we show that Juno from the golden hamster can directly interact with human Izumo1. These data suggest that the interaction between Izumo1 and Juno plays an important role in cross-species gamete recognition, and may inform the development of improved prognostic tests that do not require the use of animals to guide the most appropriate fertility treatment for infertile couples.
The Hippocampus Supports Both Recollection and Familiarity When Memories Are Strong

Recognition memory is thought to consist of two component processes—recollection and familiarity. It has been suggested that the hippocampus supports recollection, while adjacent cortex supports familiarity. However, the qualitative experiences of recollection and familiarity are typically confounded with a quantitative difference in memory strength (recollection > familiarity). Thus, the question remains whether the hippocampus might in fact support familiarity-based memories whenever they are as strong as recollection-based memories. We addressed this problem in a novel way by using the Remember/Know procedure, which allowed us to explicitly match the confidence and accuracy of Remember and Know decisions. As in earlier studies, recollected items had higher accuracy and confidence than familiar items, and hippocampal activity was higher for recollected items than for familiar items. Furthermore, hippocampal activity was similar for familiar items, misses, and correct rejections. When the accuracy and confidence of recollected and familiar items were matched, the findings were dramatically different. Hippocampal activity was now similar for recollected and familiar items. Importantly, hippocampal activity was also greater for familiar items than for misses or correct rejections (as well as for recollected items vs misses or correct rejections). Our findings suggest that the hippocampus supports both recollection and familiarity when memories are strong.
Pedagogic Potentials of Multimodal Literacy

This chapter discusses the changed nature of literacy within new communication contexts, the literacy that is needed for reading, viewing, responding to and producing multimodal and digital texts. Potentials for redesigning literacy pedagogy within new modes of communication are demonstrated for educational contexts. As a basis for this discussion, the author analyses classroom evidence using examples of three case studies from a research project conducted in primary schools in Sydney, Australia. In the research project teachers in several primary schools worked with the author/researcher to consider ways of redesigning literacy pedagogy within e-learning and multimodal classroom contexts. Interesting and significant changes occurred in their classroom practice. Teachers developed programs that incorporated a range of technology, including Web 2.0, and were able to maintain a balance between print-based and new literacies. Examples are presented and discussed to highlight the differences in pedagogy needed for ‘multimodal literacy’ combined with traditional literacy practices.
Experimentation at the Frontiers of Reality in Schubert Calculus

We describe the setup, design, and execution of a computational experiment utilizing a supercomputer that is helping to formulate and test conjectures in the real Schubert calculus. Largely using machines in instruc- tional computer labs during off-hours and University breaks, it consumed in excess of 350 GigaHertz-years of computing in its first six months of operation, solving over 1.1 billion polynomial systems. This experiment can serve as a model for other large scale mathematical investigations.
Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.

OBJECTIVE--To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN--Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS--H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.