Miracle-dz/UniFAR-FTUs huggingface dataset:
Social Isolation and mental Illness in old age

outmigration stream has slowed down the homogenization process inside the city.6 To the extent that the suburbs do not become as homogeneous as was assumed in the earlier stages of suburbanization, the population of the central cities will also remain heterogeneous. Furthermore, return movement to the city may reinforce existing differences. In view of these developments it seems reasonable to interpret whatever narrowing of ecological differentials may occur in both cities and suburbs as a consequence primarily of the general diminution of class differences in American society rather than as a consequence of migration and change in population size. At the same time, certain spatial differences between city and suburbs, reflecting the relative merits of each as places to live, are likely to persist regardless of class differentials. 6 Sidney Goldstein and Kurt B. Mayer, "Demographic Correlates of Status Differences in a Metropolitan Population," paper presented at the annual meetings of the Population Association of America, Philadelphia, April 25-27, 1963.
Spring assisted modular and reconfigurable robot: Design, analysis and control

This paper presents an innovative spring assisted modular and reconfigurable robot (MRR) design and control framework, which is developed based on a synergetic integration of robot control with a brake and an embedded spring at each modular joint. By activating the brake, static balancing can be established, allowing reinforced delicate operation in the neighborhood of a balanced configuration such as door opening, as well as spring assisted lift of heavy payload. The developed spring assisted MRR can improve the payload to weight ratio of the conventional robot manipulators without introducing sophisticated mechanisms. A distributed control method has been proposed to facilitate control of the spring assisted MRR. The developed control algorithm does not rely on a prior dynamic models and can suppress uncertainties introduced by module reconfigurations as well as uncertainties due to sensor inaccuracies and noises. With the developed controller, control parameters need not to be adjusted when adding modules to or removing modules from an MRR, or changing its configurations. Prototype modules have been developed, and the experimental results have confirmed the effectiveness of the proposed design and control.
Neuregulin induces GABAA receptor β2 subunit expression in cultured rat cerebellar granule neurons by activating multiple signaling pathways

The GABAA receptor β subunit is required to confer sensitivity to γ‐aminobutyric acid (GABA), the major inhibitory neurotransmitter in the CNS. In previous studies we demonstrated that the growth and differentiation factor neuregulin 1 (NRG1) selectively induced expression of the β2 subunit mRNA and encoded protein in rat cerebellar granule neurons in culture. In the present report we examine the signaling pathways that mediate this effect. These studies demonstrate that the effects of NRG1 on β2 subunit polypeptide expression require activation of the ErbB4 receptor tyrosine kinase; its effects are inhibited by pharmacological blockade of ErbB4 phosphorylation or reduction of receptor level with an antisense oligodeoxynucleotide. The NRG1‐induced activation of ErbB4 stimulates the mitogen‐activated protein kinase (MAPK), phosphatidylinositol 3‐kinase (PI3K) and cyclin‐dependent kinase‐5 (cdk5) pathways. Pharmacological blockade of any of these pathways inhibits increased β2 subunit expression, demonstrating that all three pathways are required to mediate the effects of NRG1 on GABAA receptor subunit expression in cerebellar granule neurons. These studies provide novel information concerning the actions of NRG1 on GABAA receptor expression in the CNS.
Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells

The recently cloned cytotoxic lymphocyte maturation factor (interleukin 12 [IL-12]) has been described as a growth factor for mature lymphocytes. The present study investigated whether purified recombinant murine IL-12 (rMuIL-12) also could affect the proliferation of primitive bone marrow progenitor cells. Using a population of Lin- Sca-1+ murine bone marrow stem cells, we now demonstrate that IL-12 is a potent synergistic factor for primitive hematopoietic stem cells. The synergy of IL-12 was observed in single-cell cloning assays, demonstrating that its effects are directly mediated. Specifically, IL- 12 enhanced stem cell factor-induced myelopoiesis of Lin-Sca-1+ cells sevenfold, and synergized with colony-stimulating factors (CSFs) to induce proliferation of Lin-Sca-1+ stem cells. IL-12 increased the number of responding progenitor cells as well as the size of the colonies formed. IL-12 also increased colony formation of high proliferative potential colony-forming cells with multiple CSF combinations. The effects of IL-12 were concentration dependent with a 50% effective dose of 2-20 and 20-200 ng/ml, resulting in maximum stimulation. Furthermore, a neutralizing anti-IL-12 antibody blocked the synergistic effects of rMuIL-12. In addition, IL-12 was found to have synergistic effects on more committed bone marrow progenitors as well. Our results therefore suggest that in addition to being a potent lymphopoietic stimulator, IL-12 is a regulator of the growth of hematopoietic stem cells and their myeloid progeny.
Multiplex PCRs for Identification of Necrotoxigenic Escherichia coli

ABSTRACT Two multiplex PCRs were developed for the detection of necrotoxigenic Escherichia coli virulence genes. M1 contained the primers for the toxins and the aerobactin, and M2 contained the primers for the adhesins. They were validated by single PCRs performed with reference E. coli strains and by multiplex PCRs with necrotoxigenic E. coli strains isolated from different animal species.
Dry Eye as a Mucosal Autoimmune Disease

Dry eye is a common ocular surface inflammatory disease that significantly affects quality of life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular surface homeostasis, facilitating chronic inflammation and tissue damage. Accordingly, the most effective treatments to date are geared towards reducing inflammation and restoring normal tear film. The pathogenic role of CD4+ T cells is well known, and the field is rapidly realizing the complexity of other innate and adaptive immune factors involved in the development and progression of disease. The data support the hypothesis that dry eye is a localized autoimmune disease originating from an imbalance in the protective immunoregulatory and proinflammatory pathways of the ocular surface.
An SIW fed dual-band and dual-polarized lens antenna at K/Ka-band

A dual-band and dual-polarized antenna element for K/Ka-band satellite communication systems is presented. An orthomode transducer (OMT) excites circular polarization in a square substrate integrated waveguide (SIW), that feeds an extended hemispherical dielectric lens. The feed structure is composed of a multilayer printed circuit board (PCB) and tapered superstrates. The design procedure of the components is explained and the antenna performance is presented. The measured scattering and far-field parameters validate the concept.
Real Association of Factors with Inappropriate Hospital Days

Several studies of inappropriate (in the sense of the AEP) hospital days highlighted associations between two factors (rate of inappropriateness and reasons for inappropriateness, rate of inappropriateness and appropriate setting of care,.). The aim of this communication is to present a study on real associations, at constant factor, between five factors associated with hospital inappropriate days: medical management process, reason for inappropriateness, scheduled admission, rate of inappropriateness, length of stay. We used the European version of Appropriateness Evaluation Protocol for evaluation of inappropriate days and the French protocol ;for analysis of inappropriate days. The study set in three Parisian hospitals, four clinical departments, three specialities. 523 patients were included in the study, 5663 days were evaluated on a wide variety of pathologies: 27 Medical Management Processes. Results show that there are real associations (elimination of transitive associations) between five factors : medical management process and discharge processes, reason for inappropriateness, scheduled admission, rate of inappropriate days, length of stay. Multiple Correspondence Analysis on all "groups of contiguous days related with the same reason for inappropriateness" shows five profiles of queues integrating various medical management processes.
Child neglect: outcomes in high-risk urban preschoolers.

BACKGROUND Limited longitudinal research has been conducted on the impact of neglect on children's health and well-being. There is a need to consider the impact of specific subtypes of neglect on children's functioning. In addition, there is interest in examining the cumulative effect of experiencing >1 subtype of neglect. OBJECTIVE To examine the individual and cumulative relationships among physical, psychological, and environmental neglect and children's behavior and development at age 3, and the impact on changes in children's behavior and development between ages 3 and 5. METHODS One hundred thirty-six children and their primary caregivers participating in a prospective longitudinal study of children's development and maltreatment were assessed when the children were aged 3 and 5 years. The children were recruited from primary care clinics because of failure to thrive, risk for human immunodeficiency virus, or as a comparison group. Evaluations were conducted in laboratory and home settings using observations, maternal self-report, and standardized testing of the children. Scores on physical, psychological, and environmental neglect were combined into a Cumulative Neglect Index. Regression analyses were run to examine the association of specific subtypes of neglect and of cumulative neglect with children's functioning at age 3, controlling for group, sociodemographic risk, and maternal depression. The analyses were repeated examining the impact on child outcomes at age 5, controlling for the above 3 variables as well as the children's cognitive development and behavior at age 3. RESULTS Of the subtypes of neglect at age 3, only psychological neglect was significantly associated with increased internalizing and externalizing behavior problems at age 3; the Cumulative Neglect Index was associated with internalizing problems. None of the neglect subtypes or cumulative neglect were predictive of changes in children's behavior and development between ages 3 and 5. Cognitive development of the entire sample was impaired at age 5, averaging 0.85 standard deviations below the norm, and their average externalizing behavior score was significantly problematic with an average of 0.60 standard deviations above the norm. CONCLUSIONS In the context of poverty where many preschool children have poor cognitive development and increased behavior problems, psychological neglect is significantly related to reported behavior problems. Children who experienced multiple types of neglect had increased internalizing problems. Neglect did not explain changes in children's behavior or development between ages 3 and 5. There is a need for pediatricians to identify and address child neglect, particularly psychological neglect, as early as possible. Pediatricians should also screen for maternal depression.
Natural Regeneration of Trees in Three Types of Afforested Stands in the Taihang Mountains, China

Natural regeneration is the natural process by which plants replace themselves. It is a cost-effective way to re-establish vegetation, and it helps to preserve genetic identity and diversity. In this study, we investigated the natural regeneration of trees in three types of afforested stands in the Taihang Mountains, China, which were dominated by Robinia pseudoacacia (black locust), Quercus variabilis (Chinese cork oak) and Platycladus orientalis (Chinese arborvitae) respectively. A consistent pattern was found among the three types of stands, being that the density of seedlings was positively correlated with the overstory canopy cover and negatively correlated with the covers of shrub, herb and litter layers. While a positive correlation between the density of seedlings and stand age was found for the conifer stands, negative correlations were found for the two types of broadleaf stands. Correlations between the density of saplings and the stand attributes were not consistent among the three types of stands. The two types of broadleaf stands had higher densities of seedlings and saplings than the conifer stands. While the broadleaf stands had adequate recruits for regeneration, the conifer stands did not have enough recruits. Our findings suggest that the overstory canopy should be prevented from being disturbed, any reduction of the canopy cover will decrease the recruits and affect the regeneration.
Differential dysregulation of nitric oxide production in macrophages with targeted disruptions in IFN regulatory factor-1 and -2 genes.

Recent studies have reported that IFN regulatory factor-1 (IRF-1) regulates nitric oxide (NO.) production in murine macrophages (M phi). Since IRF-2 recognizes the same consensus sequence as IRF-1, we postulated that IRF-2 may also regulate NO. Therefore, the ability of M phi from INF-2 homozygous (IRF-2-/-) and heterozygous (IRF-2+/-) knockout mice to produce NO. following LPS and/or IFN-gamma stimulation was compared with the responses of IRF-1-/-, IRF-1+/-, and C57BL/6+/+ M phi. IRF-2-/- M phi produced less LPS-induced NO2- than IRF-2+/- or C57BL/6 M phi. LPS and IFN-gamma synergized to increase NO2- production from IRF-2-/- M phi to approximately 50% of IRF-2+/- and C57BL/6 levels. Unexpectedly, IRF-2-/-, IRF-2+/- and C57BL/6 M phi produced comparable levels of inducible NO synthase mRNA in response to treatment with LPS and IFN-gamma. IRF-1-/- M phi produced barely detectable NO2- and low, but detectable, inducible NO. synthase mRNA in response to IFN-gamma and LPS. These results indicate that IRF-1 and IRF-2 differ in their mechanism of NO. regulation and that IRF-2 regulates inducible NO. synthase post-transcriptionally.
Ghrelin and obestatin in thyroid dysfunction.

INTRODUCTION Ghrelin and obestatin derive from the same precursor. Ghrelin is an energy balance regulator and obestatin's role in metabolic processes cannot be excluded. The aim of this study was to assess plasma ghrelin and obestatin changes in thyroid disorders. MATERIAL AND METHODS We evaluated plasma ghrelin and obestatin levels in severe hypothyroidism, hypothyroidism after thyreoidectomy and 4-weeks L-thyroxine withdrawal, and in hyperthyroidism. We also re-evaluated plasma ghrelin and obestatin levels in patients with severe hypothyroidism and hyperthyroidism after treatment. RESULTS Severe hypothyroidism was associated with a reasonably high ghrelin level (p = 0.055) and hyperthyroidism with a significantly lower ghrelin level (p = 0.01) compared to healthy subjects. Ghrelin in hypothyroid patients after L-thyroxine withdrawal did not differ from the control group (p = 0.3). Compared to healthy subjects, obestatin level in hyperthyroidism was decreased (p = 0.03) and did not differ in severe hypothyroidism due to thyroiditis (p = 1) or after L-thyroxine withdrawal (p = 0.6). Ghrelin and obestatin levels correlated positively. Both peptides levels correlated positively with TSH and negatively with free thyroid hormones. In patients with severe hypothyroidism, ghrelin level significantly decreased after treatment (p 〈 0.01) and in hyperthyroid patients significantly increased after treatment (p = 0.04). There were no significant changes in obestatin levels in hypo- or hyperthyroid patients after treatment. CONCLUSIONS Plasma ghrelin changes and its correlation with TSH and thyroid hormones may indicate a compensatory role of ghrelin in metabolic disturbances associated with thyroid dysfunction. The positive correlation between ghrelin and obestatin levels may suggest a modulatory role of obestatin in these processes.
Broad and load-aware anycast mapping with verfploeter

IP anycast provides DNS operators and CDNs with automatic fail-over and reduced latency by breaking the Internet into catchments, each served by a different anycast site. Unfortunately, understanding and predicting changes to catchments as anycast sites are added or removed has been challenging. Current tools such as RIPE Atlas or commercial equivalents map from thousands of vantage points (VPs), but their coverage can be inconsistent around the globe. This paper proposes Verfploeter, a new method that maps anycast catchments using active probing. Verfploeter provides around 3.8M passive VPs, 430x the 9k physical VPs in RIPE Atlas, providing coverage of the vast majority of networks around the globe. We then add load information from prior service logs to provide calibrated predictions of anycast changes. Verfploeter has been used to evaluate the new anycast deployment for B-Root, and we also report its use of a nine-site anycast testbed. We show that the greater coverage made possible by Verfploeter's active probing is necessary to see routing differences in regions that have sparse coverage from RIPE Atlas, like South America and China.
Selenium and Immune Cell Functions. II. Effect on Lymphocyte-Mediated Cytotoxicity

Abstract Selenium (Se) is an essential nutritional factor with a chemopreventive potential. This study examined the ability of C57BL/6J mice, maintained for 8 weeks on Se-deficient (0.02 ppm Se), normal (0.20 ppm Se), or Se-supplemented (2.00 ppm Se) Torula yeast-based diets, to generate cytotoxic lymphocytes (CTL) and to destroy tumor cells. CTL were generated in vivo by intraperitoneal immunization with P815 cells and in vitro by allogeneic stimulation of cells from animals maintained on a normal diet in media supplemented with 1 × 10-9 to 1 × 10-6 M Se (as selenite). Lymphocytes from animals maintained on the Se-supplemented diet had a greater ability to destroy tumor cells than lymphocytes from animals maintained on the normal diet, whereas Se deficiency reduced the cytotoxicity. The effects on cytotoxicity were accompanied by parallel changes in the levels of lymphotoxin produced. The greatest enhancement of tumor cytodestruction occurred with supplementation of 1 × 10-7 M Se, whereas with 1 × 10-6 M there was inhibition of the cytotoxic responses. The stimulatory effect of Se occurred during the phase of CTL generation rather than during the lytic phase of cytotoxicity. These results indicated that Se supplementation enhances CTL generation and the ability of a host to destroy malignant cells, whereas Se deficiency has the opposite effect.
Evaluation of wetting condition and its effects on pollution flashover voltage of aerodynamic insulators

The flashover performance of insulators is significantly affected by the degrees and ways of wetting the pollution layer. However, there have only been a few reports on the wetting condition and its effects on the flashover characteristics of pollution on insulators to date. In this paper, a phase-angle difference-based method is proposed to test the wetting conditions of the pollution layer on insulators. A corresponding measuring device is also developed. The wetting process of the pollution layer on aerodynamic-type glass insulators is studied in an artificial climate chamber using the developed device. The related flashover performance is studied via the even-rising voltage method. Test results show that the phase-angle difference (PAD) curve accurately reflects the entire wetting process of the pollution layer from the initial stage, through the saturated stage to the oversaturated and washing away stages. Over the wetting process, the PAD curve initially drops sharply, and then remains stable for a few minutes before eventually rising slowly to the initial value. The PAD curve has its lowest value when the pollution layer is wetted to saturation, which occurs after approximately 5 min in our experiments. The flashover voltage characteristics of insulators are also significantly affected by the wetting conditions of the pollution layer. The flashover voltage in the saturated stage is shown to be lower than that in the other stages. Therefore, to improve the accuracy of the artificial pollution tests, quantitative methods (including PAD) should be used to obtain the exact time of wetting to saturation.
Tradesperson or artist? A critical exploration of chefs' job satisfaction and turnover

The interest in experiential and embodied aspects of brand and other product usage is under-represented in tourism orientated research, which generally falls to develop a contextualised understanding of the relationships between products and consumers, and within this in particular, considerations of individuality and self, embodiment, emotion and sensation. Aiming to `reverse the causality' (Lannon and Cooper 1983:201) of consumption focused tourism research, in this paper, I draw on the tourism experiences of Audrey, a participant in a larger study to reveal how, rather than just `consuming', tourism consumers interpret the meaning and values in a wide range of products and objects, weaving individual, rich, sensory, embodied experiences which are informed by the interactions and relationships with activities and products, and by their own personalities, past experiences and aspirations. Audrey is highly conscious of her self and of elsewhereness, hers are fragile, self-indulgent, tactile experiences which offer the freedom to step out of everyday life roles into other time and situational spheres where environment, objects and sensory stimulation are paramount. [ABSTRACT FROM AUTHOR]
Effectiveness of training of spiritual intelligence components on depression, anxiety, and stress of adolescents

Objective: As the development of adolescence is identified by different types of stress and youths are further exhibited because of bodily, psychic and cultural issues, this research tried to examine the training efficacy of spiritual intelligence parts on depression, tension, and pressure of teenagers. Methodology: The present study was undergone in the initial part of the educational year 2014-2015. Moreover, it was quasi-empirical via post test-pretest, which employed a checking team. Therefore, forty of the large schoolman scholars in Tehran chose to use the utility sampling approach and registered in the test team, overlooking the group randomly (n = 20). Both groups were pretested by using a demographic survey, rate of grief, stress, and anxiety DASS-42. Eventually, the test team rose for 8 gatherings following the practice of spiritual intelligence elements and the checking team obtained no interruption. Next, both teams were post-tested, and the obtained data were analyzed by using presumed and circumstantial analytical approaches conducted through SPSS21. Results: The sequences showed that the exercise of the spiritual intelligence parts clearly decreased grief, stress, and anxiety in youths. Conclusion: The research found that because of the clear stage of the efficacy of spiritual intelligence factors training, its inexpensive and great acceptability by the youths, particularly while working in a team, it had an immense direct effect on the decrease of grief, stress, and anxiety.
A Psychometric Development of a Test for Consumer Alienation from the Marketplace

Alienation has interested philosophers and researchers for many years, but only recently has empirical study been directed toward consumer alienation from the marketplace. The author reports the development of a test to measure alienation from the marketplace based on psychometric principles. The findings suggest that a reliable and valid measure has been constructed. The consumer alienation scale was found to be unidimensional rather than consisting of identifiable subscales. In addition, areas for future research that will aid the marketing manager in applying knowledge of consumer alienation to decision making are discussed.