Miracle-dz/UniFAR-FTUs huggingface dataset:
Flowpath Delineation and Ground Water Age, Allequash Basin, Wisconsin

An analysis of ground water flowpaths to a lake and creek in northern Wisconsin shows the flow system in a geologically simple basin dominated by lakes can be surprisingly complex. Differences in source area, i.e., lakes or terrestrial, combined with the presence of intervening lakes, which may or may not capture underflowing ground water as water moves downgradient from recharge areas, contribute to a complex mix of flowpaths. The result is water of different chemistry and vastly different ages may discharge in close proximity. Flowpaths, travel times, and capture zones in the Allequash Basin in northern Wisconsin were delineated using particle tracking based on a calibrated steady‐state ground water flow model. The flowpath analysis supports the conclusions of Walker et al. (2003) who made inferences about flowpath characteristics from isotope and major ion chemistry. Simulated particle tracking agreed with Walker et al.'s measurements of water source (lake or terrestrial recharge) in the stream subsurface and also supported their assertion that ground water with a high calcium concentration in the lower basin of Allequash Lake is derived from long flowpaths. Numerical simulations show that ground water discharging in this area originates more than 5 km away in a source area located upgradient of Big Muskellunge Lake, which is upgradient of Allequash Lake. These results graphically illustrate that in settings with multiple sources of water with different age characteristics and converging flowlines (like the Allequash Basin) it may be difficult to obtain accurate estimates of ground water age by chemical analyses of ground water.
Estimation of global field aligned currents using the iridium® System magnetometer data

The Iridium® System satellite constellation consists of 66 satellites in circular, polar, 780 km altitude orbits in six equally spaced planes. Each satellite carries an engineering magnetometer which has sufficient resolution to sense the Birkeland currents. This paper presents a spherical harmonic fitting (SHF) technique for estimating field aligned currents (FACs) using the cross track component of the magnetic field measurements from the Iridium satellites. The SHF magnetic field perturbations along with Ampere's law are used to derive the global FACs from 40° MLAT to the pole in either hemisphere. Data for 10–11 UT, 23 August, 1999 were obtained from Iridium, Defense Meteorology Satellite Program (DMSP) Fl3 and the Ultraviolet Imager (UVI) onboard the POLAR satellite. The SHF data were evaluated along the DMSP F13 track. The range of east‐west component, SHF magnetic perturbations from Iridium was (−530,465) nT compared with ( −630,634) nT from DMSP F13. The derived upward FACs ranged from −0.8 to 0.9 µAm−2. Upward FACs were co‐located with bright dayside UVI emissions.
The Effect of Platinum Electrocatalyst on Membrane Degradation in Polymer Electrolyte Fuel Cells

Membrane degradation is a severe factor limiting the lifetime of polymer electrolyte fuel cells. Therefore, obtaining a deeper knowledge is fundamental in order to establish fuel cells as competitive product. A segmented single cell was operated under open circuit voltage with alternating relative humidity. The influence of the catalyst layer on membrane degradation was evaluated by measuring a membrane without electrodes and a membrane-electrode-assembly under identical conditions. After 100 h of accelerated stress testing the proton conductivity of membrane samples near the anode and cathode was investigated by means of ex situ electrochemical impedance spectroscopy. The membrane sample near the cathode inlet exhibited twofold lower membrane resistance and a resulting twofold higher proton conductivity than the membrane sample near the anode inlet. The results from the fluoride ion analysis have shown that the presence of platinum reduces the fluoride emission rate; which supports conclusions drawn from the literature.
Comment on 'Glueball spectrum from a potential model'

In a recent article, W. -S. Hou and G. -G. Wong [Phys. Rev. D 67, 034 003 (2003)] have investigated the spectrum of two-gluon glueballs below 3 GeV in a potential model with a dynamical gluon mass. We point out that, among the 18 states calculated by the authors, only three are physical. The other states either are spurious or possess a finite mass only due to an arbitrary restriction of the variational parameter.
Structural Insight into African Horsesickness Virus Infection

ABSTRACT African horsesickness (AHS) is a devastating disease of horses. The disease is caused by the double-stranded RNA-containing African horsesickness virus (AHSV). Using electron cryomicroscopy and three-dimensional image reconstruction, we determined the architecture of an AHSV serotype 4 (AHSV-4) reference strain. The structure revealed triple-layered AHS virions enclosing the segmented genome and transcriptase complex. The innermost protein layer contains 120 copies of VP3, with the viral polymerase, capping enzyme, and helicase attached to the inner surface of the VP3 layer on the 5-fold axis, surrounded by double-stranded RNA. VP7 trimers form a second, T=13 layer on top of VP3. Comparative analyses of the structures of bluetongue virus and AHSV-4 confirmed that VP5 trimers form globular domains and VP2 trimers form triskelions, on the virion surface. We also identified an AHSV-7 strain with a truncated VP2 protein (AHSV-7 tVP2) which outgrows AHSV-4 in culture. Comparison of AHSV-7 tVP2 to bluetongue virus and AHSV-4 allowed mapping of two domains in AHSV-4 VP2, and one in bluetongue virus VP2, that are important in infection. We also revealed a protein plugging the 5-fold vertices in AHSV-4. These results shed light on virus-host interactions in an economically important orbivirus to help the informed design of new vaccines.
Towards Online-Recognition with Deep Bidirectional LSTM Acoustic Models

Online-Recognition requires the acoustic model to provide posterior probabilities after a limited time delay given the online input audio data. This necessitates unidirectional modeling and the standard solution is to use unidirectional long short-term memory (LSTM) recurrent neural networks (RNN) or feed-forward neural networks (FFNN). It is known that bidirectional LSTMs are more powerful and perform better than unidirectional LSTMs. To demonstrate the performance difference, we start by comparing several different bidirectional and unidirectional LSTM topologies. Furthermore, we apply a modiﬁcation to bidirectional RNNs to enable online-recognition by moving a window over the input stream and perform one forwarding through the RNN on each window. Then, we combine the posteriors of each forwarding and we renormalize them. We show in experiments that the performance of this online-enabled bidirectional LSTM performs as good as the ofﬂine bidirectional LSTM and much better than the unidirectional LSTM.
Origin of the Basoren (Kutahya, W Turkey) bentonite deposits

Abstract Bentonite deposits in Basoren Kutahya, West Anatolia, Turkey formed from alteration of perlite and pyroclastic rocks of Pliocene age. The distribution of bentonite deposits along faults in the study area indicates that the alteration solutions were hydrothermal. Although lateral zonation is observed in bentonite deposits in some regions (i.e. Demirli, Akyokus, Seklice- Sarıokuz, etc.), alteration zones are extremely irregular in the Cayırlık bentonite deposit. X-ray diffraction studies have shown that Basoren bentonites contain dioctahedral Ca-smectite. The Greene-Kelly test (Li-saturation and heating) showed that the Demirli and Akyokus bentonites consist of montmorillonite and that the Cayırlık bentonite consists of montmorillonite and/or beidellite. Spherulitic or hemispherical ‘crystals’ of opal-CT minerals formed from hydrothermal alteration of volcanic glass. The MgO, CaO and total Fe2O3 enrichment in bentonites, compared to parent rocks, is related to the chemical composition of hydrothermal solutions that passed through the ophiolitic rocks such as serpentinite.
Palynostratigraphy of Mississippian and Pennsylvanian Rocks, Joggins Area, Nova Scotia and New Brunswick, Canada

Carboniferous rocks in the Joggins area, Nova Scotia, and the Maringouin Peninsula, New Brunswick, are world renowned for their well-preserved macroflora, but this paper is the first detailed study of the palynoflora. The section is comprised of the Mississippian Windsor and Mabou groups overlain disconformably by the Lower Pennsylvanian Cumberland Group. The Windsor Group rocks proved to be barren of palynomorphs but the Mabou Group yielded spores and pollen of Brigantian (late Viséan) to Arnsbergian age (early Namurian = early Serpukhovian). The assemblages are assigned successively to the Schopfipollenites acadiensis—Knoxisporites triradiatus, the Grandispora spinosa—Ibrahimispores magnificus, and the Reticulatisporites carnosus Zones. A major palynofloral change takes place between the Mississippian Mabou and the Pennsylvanian Cumberland assemblages. This is believed to reflect a significant regional hiatus in the Joggins section and elsewhere in eastern Canada. The Cumberland Group is characterized by an abundance of Lycospora spp. and monosaccate gymnosperm species of Yeadonian? (Late Namurian = middle Bashkirian? ) to late Duckmantian (late Bashkirian? ) age. The palynological succession is divided into the Raistrickia saetosa, the Raistrickia fulva, and the Vestispora magna zones. Age determinations of the zones, based on comparisons with Western Europe and the North Sea, are tentative because the Cumberland assemblages lack diversity and many taxa diagnostic in Western Europe are absent in the assemblages of the Joggins area, possibly due to environmental and climatic differences. Geological Survey of Canada Contribution Number: 20090031
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

Significance Epigenetic inhibitors have shown considerable promise for the treatment of malignant and inflammatory diseases. We present here the detailed characterization of a potent and highly selective inhibitor of the bromodomains of CBP (CREB binding protein)/p300. Functional preclinical data studying cells derived from patients with ankylosing spondylitis and psoriatic arthritis (two human Th17-driven diseases) show that selective inhibition of the CBP/p300 bromodomain with CBP30 strongly reduces secretion of IL-17A, without having the broader and potentially deleterious effects on cytokine production and gene transcription of the pan-BET (bromo and extraterminal domain protein family) inhibitor JQ1. CBP/p300 play a significant role in IL-17A production, and CBP/p300 inhibition is a promising therapeutic strategy in human type-17–mediated diseases such as ankylosing spondylitis and psoriatic arthritis. Th17 responses are critical to a variety of human autoimmune diseases, and therapeutic targeting with monoclonal antibodies against IL-17 and IL-23 has shown considerable promise. Here, we report data to support selective bromodomain blockade of the transcriptional coactivators CBP (CREB binding protein) and p300 as an alternative approach to inhibit human Th17 responses. We show that CBP30 has marked molecular specificity for the bromodomains of CBP and p300, compared with 43 other bromodomains. In unbiased cellular testing on a diverse panel of cultured primary human cells, CBP30 reduced immune cell production of IL-17A and other proinflammatory cytokines. CBP30 also inhibited IL-17A secretion by Th17 cells from healthy donors and patients with ankylosing spondylitis and psoriatic arthritis. Transcriptional profiling of human T cells after CBP30 treatment showed a much more restricted effect on gene expression than that observed with the pan-BET (bromo and extraterminal domain protein family) bromodomain inhibitor JQ1. This selective targeting of the CBP/p300 bromodomain by CBP30 will potentially lead to fewer side effects than with the broadly acting epigenetic inhibitors currently in clinical trials.
Letters to the Editor.

We read with great interest the article by Weber et al. entitled ‘Heart rate variability (HRV) and ischaemia in patients with coronary artery disease (CAD) and stable angina pectoris; influence on drug therapy and prognostic value’. We would like to add some comments. It has been suggested in previous studies that decreased HRV is a strong predictor of cardiac events in patients after acute myocardial infarction (MI). An interesting finding of the study of Weber et al. is that none of the 422 patients with stable angina (including 152 patients with a previous MI of more than 6 months) had a SDNN (standard deviation of the mean of all corrected RR intervals) below 50 ms, a cut-off level previously reported for risk stratification. The authors suggest that the population studied was at low risk of cardiac events. It was stated that there were no patients with poor left ventricular pumping performance, although no precise data are given about a haemodynamic status and/or systolic function. The prognostic value of decreased HRV in heart failure had been discussed for many years before the recent definitive results of the prospective U.K. Heart study, whereas it has been accepted as of prognostic value in post myocardial infarction patients. The non-significant prognostic value of the decrease in HRV in the study of Weber et al. may be due to the relatively short follow-up of 1 year. It should also be suggested that a decrease in HRV may only be able to detect at risk patients with both CAD (with or without MI) and systolic dysfunction. CAD alone is not specifically and independently associated with a reduced index of parasympathetic activity in patients with severe uncomplicated CAD. An interesting aspect of the work of Weber et al. is the attempt to evaluate Article No. euhj.1999. 1651, available online at http://www.idealibrary. com on
THE ABUNDANCE OF PREMETAMORPHIC NEWTS (TRITURUS CRISTATUS, T. MARMORATUS) AS A FUNCTION OF HABITAT DETERMINANTS: AN A PRIORI MODEL SELECTION APPROACH

Despite the key role of premetamorphic amphibians in experimental ecology, the factors affecting their abundance has received relatively little attention in natural settings. We applied a model selection approach with AIC (Akaike's Information Criterion) to predict the abundance of embryos and larvae of crested and marbled newts (Triturus cristatus and T. marmoratus) at 32 breeding sites in western France, based on 15 variables describing the aquatic habitat, and 10 variables describing the terrestrial habitat within a 100 m radius around the pond. The best model for embryos included the variables shade and floating vegetation (highest embryo abundance in intermediate ponds), and pond size (negative correlation). Larval abundance was best explained by shade (negative correlation), and the interaction between phosphate and nitrate. Pond variables were not fully comparable to terrestrial parameters, but produced better predictive models for both embryos and larvae. Due to the high explanatory value of ecological parameters the results suggest that in a metapopulation context, deterministic population processes driven by pond succession may be more important than stochastic extinctions and recolonizations of otherwise suitable habitat patches.
Brucella dissociation is essential for macrophage egress and bacterial dissemination

It has long been observed that smooth Brucella can dissociate into rough mutants that are cytotoxic to macrophages. However, the in vivo biological significance and/or mechanistic details of Brucella dissociation and cytotoxicity remain incomplete. In the current report, a plaque assay was developed using Brucella strains exhibiting varying degrees of cytotoxicity. Infected monolayers were observed daily using phase contrast microscopy for plaque formation while Brucella uptake and replication were monitored using an immunofluorescence assay (IFA). Visible plaques were detected at 4–5 days post infection (p.i.) with cytotoxic Brucella 16MΔmanBA at an MOI of 0.1. IFA staining demonstrated that the plaques consisted of macrophages with replicating Brucella. Visible plaques were not detected in monolayers infected with non-cytotoxic 16MΔmanBAΔvirB2 at an MOI of 0.1. However, IFA staining did reveal small groups of macrophages (foci) with replicating Brucella in the monolayers infected with 16MΔmanBAΔvirB2. The size of the foci observed in macrophage monolayers infected with rough Brucella correlated directly with cytotoxicity measured in liquid culture, suggesting that cytotoxicity was essential for Brucella egress and dissemination. In monolayers infected with 16M, small and large foci were observed. Double antibody staining revealed spontaneous rough mutants within the large, but not the small foci in 16M infected monolayers. Furthermore, plaque formation was observed in the large foci derived from 16M infections. Finally, the addition of gentamicin to the culture medium inhibited plaque formation, suggesting that cell-to-cell spread occurred only following release of the organisms from the cells. Taken together, these results demonstrate that Brucella-induced cytotoxicity is critical for Brucella egress and dissemination.
Impact of Different Concentrations of Human Recombinant Growth Hormone on T Lymphocytes

The aim of the present study is to evaluate the effects induced by increasing concentrations of human recombinant growth hormone on T lymphocytes. Ten healthy volunteers and twelve subjects with symptomatic allergies were enrolled in the study. Peripheral blood mononuclear cells and purified T lymphocytes were cultured in the presence of graded concentrations of growth hormone. Following appropriate in vitro stimulations, the proportion of apoptotic T cells, the percentage of activated T lymphocyte subpopulations, the phytohemagglutinin responsiveness and the Th2 response were assessed by flow cytometry analysis. Moreover, in order to evaluate the phosphoinositol-3-kinase signaling pathway involvement, cells were also analyzed after treatment with LY294002. The treatment with different concentrations of growth hormone did not influence the activation pattern of un-stimulated T lymphocytes. On the contrary, growth hormone was able to modify the CD38/HLA-DR co-expression of T cells activated with phytohemoagglutinin. A different response was observed when samples obtained from healthy donors and from subjects with symptomatic allergies were analysed. Moreover, growth hormone treatment was able to increase the Th2 response in the samples obtained from healthy donors only. The results of the present study strongly support the hypothesis that growth hormone administration may play an important role in conditions of impaired/activated immune systems. The observation that growth hormone administration at high doses may reverse its effects and that it may promote a Th2-oriented response have significant clinical implications when considering the use of this hormone for artificially enhancing the physical performances of healthy athletes.
Effects of Orthokin, Sensikin and Persica mouth rinses on the force degradation of elastic chains and NiTi coil springs

Background. Elastomeric chains and NiTi coil springs are two major traction aids in orthodontic tooth movements. Force degradation occurs over time in both groups, with higher percentages in elastic chains. The effects of environmental factors and some mouth rinses on this force decay have been previously studied. No study has been performed to evaluate the effect of current popular mouth rinses such as Orthokin, Sensikin and Persica on this force degradation. Methods. Forty pieces of elastic chains consisting of 5 loops (Ortho Technology, USA) and 40 NiTi closed coil springs (3M Unitek, Germany) were divided into 4 groups: control (artificial saliva), Orthokin mouthwash, Sensikin mouthwash and Persica mouthwash. All the groups were kept in an incubator at 37°C for 3 weeks. In the test groups, the samples were immersed in mouthwash twice a day. Force degradation was measured at 5 time intervals: baseline, 1 hour, 24 hours, 1 week and 3 weeks, using a digital force gauge. Repeated-measures ANOVA and one-way ANOVA were used for statistical analysis. Results. Force decay occurred over time in both elastic chainand coil spring groups. In elastic chain group, after 3 weeks, Orthokin mouth rinse had significantly lower force degradation compared to other groups (P < 0.05) and in coil spring group there were no statistically significant differences in force degradation after 3 weeks between the subgroups (P > 0.05). Conclusion. Based the results of this study, these three mouthwashes did not increase the force degradation of orthodontic traction aids under study.
Quality achievement and disease prevalence in primary care predicts regional variation in renal replacement therapy (RRT) incidence: an ecological study.

BACKGROUND Diabetes Meillitus (DM) and hypertension (HT) are important causes of end-stage renal disease (ESRD) and renal replacement therapy (RRT) is the standard active treatment. Financially, incentivized quality initiatives for primary care include pay-for-performance (P4P) in DM and HT. Our aim was to examine any effect of disease prevalence and P4P on RRT incidence and regional variation. METHODS The incidence of RRT, sex and ethnicity data and P4P disease register and achievement data were obtained for each NHS locality. We calculated correlation coefficients for P4P indicators since 2004/05 and socio-demographic data for these 152 localities. We then developed a regression model and regression coefficient (R(2)) to assess to what extent these variables might predict RRT incidence. RESULTS Many of the P4P indicators were weakly but highly significantly correlated with RRT incidence. The strongest correlation was 2004/05 for DM prevalence and 2006/07 for HT quality. DM prevalence and the percentage with blood pressure control in HT target (HT quality) were the most predictive in our regression model R(2) = 0.096 and R(2) = 0.085, respectively (P < 0.001). Combined they predicted a fifth of RRT incidence (R(2) = 0.2, P < 0.001) while ethnicity and deprivation a quarter (R(2) = 0.25, P < 0.001). Our final model contained proportion of population >75 years, DM prevalence, HT quality, ethnicity and deprivation index and predicted 40% of variation (R(2) = 0.4, P < 0.001). CONCLUSION Our findings add prevalence of DM and quality of HT management to the known predictors of variation in RRT, ethnicity and deprivation. They raise the possibility that interventions in primary care might influence later events in specialist care.
Burying Uncertainty: Risk and the Case Against Geological Disposal of Nuclear Waste

Acknowledgments Preface 1. The Riddle of Nuclear Waste 2. Understanding the Origins of the Problem 3. Reliance on Value Judgements in Repository Rock Assessment 4. Subjective Estimates of Repository Risks 5. Subjective Evaluations of Repository Risks 6. Problematic Inferences in Assessing Repository Risks 7. Uncertainty: An Obstacle to Geological Disposal 8. Equity: An Obstacle to Geologic Disposal 9. An Alternative to Permanent Geological Disposal