Miracle-dz/UniFAR-FTUs huggingface dataset:
Overcoming the Brittleness Bottleneck using Wikipedia: Enhancing Text Categorization with Encyclopedic Knowledge

When humans approach the task of text categorization, they interpret the specific wording of the document in the much larger context of their background knowledge and experience. On the other hand, state-of-the-art information retrieval systems are quite brittle--they traditionally represent documents as bags of words, and are restricted to learning from individual word occurrences in the (necessarily limited) training set. For instance, given the sentence "Wal-Mart supply chain goes real time", how can a text categorization system know that Wal-Mart manages its stock with RFID technology? And having read that "Ciprofloxacin belongs to the quinolones group", how on earth can a machine know that the drug mentioned is an antibiotic produced by Bayer? In this paper we present algorithms that can do just that. We propose to enrich document representation through automatic use of a vast compendium of human knowledge--an encyclopedia. We apply machine learning techniques to Wikipedia, the largest encyclopedia to date, which surpasses in scope many conventional encyclopedias and provides a cornucopia of world knowledge. Each Wikipedia article represents a concept, and documents to be categorized are represented in the rich feature space of words and relevant Wikipedia concepts. Empirical results confirm that this knowledge-intensive representation brings text categorization to a qualitatively new level of performance across a diverse collection of datasets.
Bolus Estimation—Rethinking the Effect of Meal Fat Content

Abstract Background: Traditionally, insulin bolus calculations for managing postprandial glucose levels in individuals with type 1 diabetes rely solely on the carbohydrate content of a meal. However, recent studies have reported that other macronutrients in a meal can alter the insulin required for good postprandial control. Specifically, studies have shown that high-fat (HF) meals require more insulin than low-fat (LF) meals with identical carbohydrate content. Our objective was to assess the mechanisms underlying the higher insulin requirement observed in one of these studies. Materials and Methods: We used a combination of previously validated metabolic models to fit data from a study comparing HF and LF dinners with identical carbohydrate content in seven subjects with type 1 diabetes. For each subject and dinner type, we estimated the model parameters representing the time of peak meal-glucose appearance (τm), insulin sensitivity (SI), the net hepatic glucose balance, and the glucose effect at zero insulin in four time windows (dinner, early night, late night, and breakfast) and assessed the differences in model parameters via paired Wilcoxon signed-rank tests. Results: During the HF meal, the τm was significantly delayed (mean and standard error [SE]: 102 [14] min vs. 71 [4] min; P = 0.02), and SI was significantly lower (7.25 × 10−4 [1.29 × 10−4] mL/μU/min vs. 8.72 × 10−4 [1.08 × 10−4] mL/μU/min; P = 0.02). Conclusions: In addition to considering the putative delay in gastric emptying associated with HF meals, we suggest that clinicians reviewing patient records consider that the fat content of these meals may alter SI.
Stiffness Evaluation of Neoprene Bearing Pads Under Long-Term Loads

The objective of this project was to evaluate the interaction between the shear modulus of steel reinforced neoprene bearing pads and shear strain rate. The following interactions related to variations in the shear modulus were investigated for pads with various shape factors: product approval strain rates vs. short-term field strain rates, short-term field strain rates vs. long-term field strain rates, reduction in shear modulus due to load cycles, and effects of compressive stress. Forty-two tests were performed using test equipment designed to apply a shear strain at a variety of rates (50% shear strain at rates from 45 seconds to 90 days) while applying a sustained compressive load. Test results indicated: the shear modulus reduced on average 7% when tests were performed using the short-term field strain rates of 50% over 12 hours instead of the product approval strain rates of 50% over 30-60 seconds, there was essentially no reduction in shear modulus using long-term field loading rates of 50% over durations up to 90 days vs. short-term field strain rates, the shear moduli for pads that had never been load cycled were approximately 12% higher than cycled pads, and the effect of compressive stress agrees with previous work (i.e., the shear modulus decreases with increased compression particularly for bearings with low shape factors). Recommendations for upper and lower limits on the shear modulus to be used in design are included.
Effects of Tillage Practices and Manure Application on Phosphorus Transport in Tile Drain Effluent Under a Silt Loam Soil in Ontario, Canada

EFFECTS OF TILLAGE PRACTICES AND MANURE APPLICATION ON PHOSPHORUS TRANSPORT IN TILE DRAIN EFFLUENT UNDER A SILT LOAM SOIL IN ONTARIO, CANADA Christopher Duits Co-Advisor: University of Guelph, 2018 Dr. Ivan O’Halloran University of Guelph Co-Advisor: Dr. Merrin Macrae University of Waterloo This thesis is an investigation of the relationship between different forms of P that are found in tile drain effluent following the summer/fall application of liquid dairy manure on three different tillage systems during the period of 2014 to 2015. Three plots were used, each associated with a different tillage system (conventional and minimum till). Tile water samples were taken during flow periods and were analyzed for total P (particulate + dissolved) and soluble reactive P. Results provide evidence that conventional tillage may be effective in disturbing the continuity of macropores and essentially reducing the drainage rates of the soil. Following manure application, there was an increase in SRP identified in the conventional till plot, indicating that minimum till may be effective in reducing the amount of SRP leaving the field during the first few flow periods following manure application.
Control over interfering memories in eating disorders

ABSTRACT Introduction: Recent studies have suggested that patients suffering from either anorexia nervosa (AN) or bulimia nervosa (BN) exhibit abnormal performance in the ability to control cognitive interference in response selection. Method: We assessed the status of cognitive control in episodic memory by addressing the ability to inhibit interfering memories. To this end, we used the retrieval-practice paradigm, which allows for measuring both the beneficial and the detrimental effects of memory practice. The latter phenomenon, known as retrieval-induced forgetting (RIF), is thought to reflect an adaptive inhibitory mechanism aimed at reducing competition in memory retrieval. Twenty-seven healthy controls and 27 patients suffering from eating disorders (either AN or BN) performed a retrieval-practice paradigm and a control task addressing general reactivity and filled a self-report questionnaire on impulsivity. Results: No differences between patients and healthy controls were observed for the beneficial effects of practice. The same pattern also emerged for RIF. However, when patients with AN and BN were analyzed separately, a clear dissociation emerged: patients with AN displayed no hint of RIF, whereas patients with BN showed an intact memory suppression performance. No group differences emerged in the control task. Conclusions: Our findings suggest a specific impairment in the ability to suppress interfering memories in patients with AN, thus extending current evidence of cognitive control deficits in AN to episodic memory.
A Simple Parallel Algorithm for Biconnected Components in Sparse Graphs

In this paper we design and implement an algorithm for finding the biconnected components of a given graph. Our algorithm is based on experimental evidence that finding the bridges of a graph is usually easier and faster in the parallel setting. We use this property to first decompose the graph into independent and maximal 2-edge-connected sub graphs. To identify the articulation points in these 2-edge connected sub graphs, we again convert this into a problem of finding the bridges on an auxiliary graph. It is interesting to note that during the conversion process, the size of the graph may increase. However, we show that this small increase in size and the run time is offset by the consideration that finding bridges is easier in a parallel setting. We implement our algorithm on an Intel i7 980X CPU running 12 threads. We show that our algorithm is on average 2.45x faster than the best known current algorithms implemented on the same platform.
The Crystal Structures of Apo and cAMP-Bound GlxR from Corynebacterium glutamicum Reveal Structural and Dynamic Changes upon cAMP Binding in CRP/FNR Family Transcription Factors

The cyclic AMP-dependent transcriptional regulator GlxR from Corynebacterium glutamicum is a member of the super-family of CRP/FNR (cyclic AMP receptor protein/fumarate and nitrate reduction regulator) transcriptional regulators that play central roles in bacterial metabolic regulatory networks. In C. glutamicum, which is widely used for the industrial production of amino acids and serves as a non-pathogenic model organism for members of the Corynebacteriales including Mycobacterium tuberculosis, the GlxR homodimer controls the transcription of a large number of genes involved in carbon metabolism. GlxR therefore represents a key target for understanding the regulation and coordination of C. glutamicum metabolism. Here we investigate cylic AMP and DNA binding of GlxR from C. glutamicum and describe the crystal structures of apo GlxR determined at a resolution of 2.5 Å, and two crystal forms of holo GlxR at resolutions of 2.38 and 1.82 Å, respectively. The detailed structural analysis and comparison of GlxR with CRP reveals that the protein undergoes a distinctive conformational change upon cyclic AMP binding leading to a dimer structure more compatible to DNA-binding. As the two binding sites in the GlxR homodimer are structurally identical dynamic changes upon binding of the first ligand are responsible for the allosteric behavior. The results presented here show how dynamic and structural changes in GlxR lead to optimization of orientation and distance of its two DNA-binding helices for optimal DNA recognition.
Effects of Subchronic Exposures to Concentrated Ambient Particles (CAPs) in Mice: IV. Characterization of Acute and Chronic Effects of Ambient Air Fine Particulate Matter Exposures on Heart-Rate Variability

Abstract Long-term exposure to fine particulate air pollution (PM2.5) has been associated with increased risk of death from cardiopulmonary diseases. Cardiac function parameters have also been affected by ambient particulate matter (PM) exposure, including heart-rate variability (HRV), a measure of autonomic function that has been recognized as a well-defined, quantitative indicator of autonomic dysfunction. However, the role of HRV in ambient PM-induced cardiovascular effects is not fully understood. In an accompanying article, we report significant decreasing patterns of heart rate (HR), body temperature, and physical activity for mice lacking apoliproprotein (ApoE−/−) over 5 mo of exposure to concentrated ambient PM (CAPs), with smaller and nonsignificant changes for C57 mice. In this article, we report the effects of subchronic CAPs exposure on HRV parameters that are sensitive to cardiac sympathetic and parasympathetic nerve activity. The standard deviation of normal to normal beat intervals (SDNN) and the square root of the mean squared differences of successive RR intervals (RMSSD) in the late afternoon and overnight for the ApoE−/− mice showed a gradual increase for the first 6 wk, a decline for about 12 more wk, and a slight turn upward at the end of the study period. For C57 mice, there were no chronic effect changes of SDNN or RMSSD in the late afternoon, and a slight increase after 6 wk for the overnight period. The response patterns of ApoE−/− mice indicated a perturbation of the homeostatic function in the cardiovascular system (initial enhancement and later depression of the HRV parameters). Our results complement the findings in human panel and controlled CAPs exposure studies in demonstrating that increased levels of particle pollution are able to perturb cardiac autonomic function, which may lead to adverse cardiovascular outcomes.
Transient infection of the zebrafish notochord with E. coli induces chronic inflammation

Zebrafish embryos and larvae are now well-established models in which to study infectious diseases. Infections with non-pathogenic Gram-negative Escherichia coli induce a strong and reproducible inflammatory response. Here, we study the cellular response of zebrafish larvae when E. coli bacteria are injected into the notochord and describe the effects. First, we provide direct evidence that the notochord is a unique organ that is inaccessible to leukocytes (macrophages and neutrophils) during the early stages of inflammation. Second, we show that notochord infection induces a host response that is characterised by rapid clearance of the bacteria, strong leukocyte recruitment around the notochord and prolonged inflammation that lasts several days after bacteria clearance. During this inflammatory response, il1b is first expressed in macrophages and subsequently at high levels in neutrophils. Moreover, knock down of il1b alters the recruitment of neutrophils to the notochord, demonstrating the important role of this cytokine in the maintenance of inflammation in the notochord. Eventually, infection of the notochord induces severe defects of the notochord that correlate with neutrophil degranulation occurring around this tissue. This is the first in vivo evidence that neutrophils can degranulate in the absence of a direct encounter with a pathogen. Persistent inflammation, neutrophil infiltration and restructuring of the extracellular matrix are defects that resemble those seen in bone infection and in some chondropathies. As the notochord is a transient embryonic structure that is closely related to cartilage and bone and that contributes to vertebral column formation, we propose infection of the notochord in zebrafish larvae as a new model to study the cellular and molecular mechanisms underlying cartilage and bone inflammation.
The Anatomy and Clinical Applications of the Buccal Fat Pad

The buccal fat pad is an anatomically complex structure that has great importance in facial contour. In properly selected individuals, judicious harvesting of buccal fat can produce dramatic changes in facial appearance by reducing the fullness of the cheek and highlighting the malar eminences. Using fresh cadaver dissection, the anatomy of the buccal fat pad is delineated and its relationship to the masticatory space, facial nerve, and parotid duct is defined. An intraoral approach for buccal fat harvesting is described based on these anatomic findings. Clinical experience manipulating the buccal fat pad for aesthetic modification of facial contour is illustrated.
An Improved Particle Swarm Optimization (PSO)–Based MPPT for PV With Reduced Steady-State Oscillation

This paper proposes an improved maximum power point tracking (MPPT) method for the photovoltaic (PV) system using a modified particle swarm optimization (PSO) algorithm. The main advantage of the method is the reduction of the steady- state oscillation (to practically zero) once the maximum power point (MPP) is located. Furthermore, the proposed method has the ability to track the MPP for the extreme environmental condition, e.g., large fluctuations of insolation and partial shading condition. The algorithm is simple and can be computed very rapidly; thus, its implementation using a low-cost microcontroller is possible. To evaluate the effectiveness of the proposed method, MATLAB simulations are carried out under very challenging conditions, namely step changes in irradiance, step changes in load, and partial shading of the PV array. Its performance is compared with the conventional Hill Climbing (HC) method. Finally, an experimental rig that comprises of a buck-boost converter fed by a custom-designed solar array simulator is set up to emulate the simulation. The soft- ware development is carried out in the Dspace 1104 environment using a TMS320F240 digital signal processor. The superiority of the proposed method over the HC in terms of tracking speed and steady-state oscillations is highlighted by simulation and experimental results.
Cytokines expression in saliva and peri-implant crevicular fluid of patients with peri-implant disease.

OBJECTIVE This study aimed to measure the levels of GM-CSF, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IFN-γ and TNF-α in peri-implant crevicular fluid (PICF) and saliva from patients with peri-implant disease. METHODS Twenty two total edentulous patients were divided into two groups: Mucositis (MU) patients with bone loss around the implants until the first thread and pocket depth ≤3 mm, and Peri-implantitis (PI) patients with at least one implant with bone loss around two or more threads and pocket depth ≥4 mm. The clinical parameters evaluated were probing pocket depth, bleeding on probing, and percentage of plaque. PICF samples were collected from MU sites, and from shallow (SPI) and deep (DPI) sites in PI. Unstimulated whole and parotid duct saliva was collected from all patients. The cytokines were measured by a multiplexed immunoassay. RESULTS PI patients had a higher percentage of plaque compared with MU (P = 0.02). MU sites had lower pocket depth compared to SPI (P = 0.001) and to DPI (P ≤ 0.001). In PICF, the levels of IL-1β were significantly higher in SPI sites compared to MU (P = 0.03). In the saliva from parotid, IL-8 and IL-12 were significantly higher in patients with PI (P = 0.04). CONCLUSION Elevated levels of IL-1β in PICF seem to be a characteristic trait of patients with peri-implantitis. The parotid duct saliva showed a significant increase in expression of IL-8, which might be related to a systemic response.
The 12-Month Effects of Early Motivational Interviewing After Acute Stroke: A Randomized Controlled Trial

Background and Purpose— The purpose of this study was to determine whether motivational interviewing (MI), a patient-centered counseling technique, can benefit patients' mood and mortality poststroke. Methods— This was a single-center, open, randomized, controlled trial. The setting was a hospital with a stroke unit. Four hundred eleven consecutive patients on the stroke register were >18 years old, not known to be moving out-of-area postdischarge, not receiving psychiatric or clinical psychology intervention, and were without severe cognitive or communication problems preventing participation in interviews. All patients received usual stroke care. Patients in the intervention group also received 4 individual, weekly sessions of MI. The primary outcome was the proportion of patients with normal mood measured by the 28-item General Health Questionnaire (normal <5; low ≥5) using a mailed questionnaire at 12 months poststroke. Results— At 12-month follow-up (including imputed data), 37.7% patients in the control group and 48.0% patients in the intervention group had normal mood. Twenty-five (12.8%) of 195 patients in the control group and 13 (6.5%) of 199 patients in the intervention group had died. A significant benefit of motivational interviewing over usual stroke care was found for mood (P=0.020; OR, 1.66; 95% CI, 1.08 to 2.55) and mortality (P=0.035; OR, 2.14; 95% CI, 1.06 to 4.38). Conclusions— Results suggest that motivational interviewing improves patients' mood and reduces mortality 12 months poststroke. Clinical Trial Registration— URL: www.controlled-trials.com. Unique identifier: ISRCTN54465472.
BCube: a high performance, server-centric network architecture for modular data centers

This paper presents BCube, a new network architecture specifically designed for shipping-container based, modular data centers. At the core of the BCube architecture is its server-centric network structure, where servers with multiple network ports connect to multiple layers of COTS (commodity off-the-shelf) mini-switches. Servers act as not only end hosts, but also relay nodes for each other. BCube supports various bandwidth-intensive applications by speeding-up one-to-one, one-to-several, and one-to-all traffic patterns, and by providing high network capacity for all-to-all traffic. BCube exhibits graceful performance degradation as the server and/or switch failure rate increases. This property is of special importance for shipping-container data centers, since once the container is sealed and operational, it becomes very difficult to repair or replace its components. Our implementation experiences show that BCube can be seamlessly integrated with the TCP/IP protocol stack and BCube packet forwarding can be efficiently implemented in both hardware and software. Experiments in our testbed demonstrate that BCube is fault tolerant and load balancing and it significantly accelerates representative bandwidth-intensive applications.
A new culture medium for recovering the agents of Cryptococcosis from environmental sources

The isolation of Cryptococcosis agents from environmental samples may be difficult due to the presence of groups of fast-growing fungi. We propose a new culture medium based on a modification of Dichloran Rose-Bengal Chloramphenicol Medium (DRBCm) to detect colonies of Cryptococcus neoformans. Our results indicate that DRBCm is superior to the classical Bird Seed Agar in its ability to detect colonies of C. neoformans.
Rwandan Political Violence in Space and Time Christian Davenport University of Notre Dame christiandavenport

Acknowledgements – we wish to thank the following institutions for assistance: National Science Foundation, the National University of Rwanda in Butare – in particular, the Centre for Conflict Management, the University of Maryland, in particular, the Center for International Development and Conflict Management, Dartmouth College, and the International Criminal Tribunal on Rwanda. We would also like to thank the following individuals for assistance: Tricia Luong, David Armstrong, Alan Kuperman, William Seltzer and a variety of individuals who will remain nameless.
Bmc Musculoskeletal Disorders Long Term In-vivo Studies of a Photo-oxidized Bovine Osteochondral Transplant in Sheep

Background: Articular cartilage has limited capacity to repair. Defects greater than 3 mm heal with formation of inferior fibrous cartilage. Therefore, many attempts have been made to find the ideal graft for larger cartilage lesions. Different grafts, such as untreated or cryopreserved osteochondral transplants, have been used with variable success.