Miracle-dz/UniFAR-FTUs huggingface dataset:
GT-SEER: Geo-Temporal SEquential Embedding Rank for Point-of-interest Recommendation

Point-of-interest (POI) recommendation is an important application in location-based social networks (LBSNs), which learns the user preference and mobility pattern from check-in sequences to recommend POIs. However, previous POI recommendation systems model check-in sequences based on either tensor factorization or Markov chain model, which cannot capture contextual check-in information in sequences. The contextual check-in information implies the complementary functions among POIs that compose an individual's daily check-in sequence. In this paper, we exploit the embedding learning technique to capture the contextual check-in information and further propose the \textit{{\textbf{SE}}}quential \textit{{\textbf{E}}}mbedding \textit{{\textbf{R}}}ank (\textit{SEER}) model for POI recommendation. In particular, the \textit{SEER} model learns user preferences via a pairwise ranking model under the sequential constraint modeled by the POI embedding learning method. Furthermore, we incorporate two important factors, i.e., temporal influence and geographical influence, into the \textit{SEER} model to enhance the POI recommendation system. Due to the temporal variance of sequences on different days, we propose a temporal POI embedding model and incorporate the temporal POI representations into a temporal preference ranking model to establish the \textit{T}emporal \textit{SEER} (\textit{T-SEER}) model. In addition, We incorporate the geographical influence into the \textit{T-SEER} model and develop the \textit{\textbf{Geo-Temporal}} \textit{{\textbf{SEER}}} (\textit{GT-SEER}) model.
Vertical integration, competition, and financial exchanges: Is there grain in the silo?

We investigate the incentives for vertical or horizontal integration in the financial security service industry, consisting of trading, clearing and settlement. We thereby focus on firms' decisions but also look on the implications of these decisions on competition and welfare. Our analysis shows that the incentives for vertical integration crucially depend on industry as well as market characteristics. A more pronounced demand for liquidity clearly favors vertical integration whereas deeper financial integration increases the incentives to undertake vertical integration only if the efficiency gains associated with vertical integration are sufficiently large. Furthermore, we show that market forces can suffer from a coordination problem that end in vertically integrated structures that are not in the best interest of the firms. We believe this problem can be addressed by policy measures such as the TARGET2-Securities program. Furthermore, we use our framework to discuss major industry trends and policy initiatives.
Fixed solar urticaria induced by UVA and visible light: a report of a case

Fixed solar urticaria (FSU) is a rare and less severe subgroup of solar urticaria. It is characterized by urticarial eruptions, which occurs on the same parts of the body following sun exposure. The lesions are reproducible at the same sites with similar morphology and distribution pattern after repeated sun exposure. The action spectrum of FSU is broad (300–700 nm). We reported a case of FSU induced by UVA and visible light. The patient responded well to cetirizine treatment.
Narrative therapy in a learning disability context: a review

Purpose – Narrative therapy is aligned with government priorities for learning disabilities as it promotes inclusion and seeks to empower. While research on narrative therapy in learning disability services is emerging, it has not been critically evaluated. The purpose of this paper is to identify, summarise and critique the extant literature that has explored narrative therapy for adults with learning disabilities, and consider the implications for research and clinical practice. Design/methodology/approach – A literature search identified seven relevant case studies that described individual narrative therapy interventions for adults with learning disabilities. A qualitative review of these studies was carried out. Findings – Overall, the reviewed studies offer tentative evidence for the short-term usefulness of narrative therapy for difficulties with anger and qualitative benefits for ritualistic behaviour, social anxiety and stealing behaviour. Research limitations/implications – A number of methodolo.
Occurrence of candida in oral leukoplakias.

Biopsies from 235 patients with oral leukoplakias were investigated, (83 speckled leukoplakias, and 152 homogeneous leukoplakias). A candidal invation was found in 23 per cent of the leukoplakias (in 61 per cent of the speckled leukoplakias, and in 3 per cent of the homogeneous leukoplakias). Epithelial atypia was associated with concurrent Candida in 61 per cent of the speckled leukoplakias, while epithelial atypia occurred in 88 per cent of the speckled leukoplakias which were not affected by Candida.
Respiratory Syncytial Virus Laboratory Surveillance and Hospitalization Trends in South Texas

Surveillance of seasonal variations in respiratory syncytial virus (RSV) outbreaks is an important component in clinical decision-making. A retrospective analysis of 11 years of laboratory-based RSV surveillance and 7 years of hospitalization data was carried out to better define the onset and duration of the RSV season in South Texas, as well as to evaluate the clinical impact and timing of RSV outbreaks on the number of infants hospitalized with RSV infection. All but one of the seasons examined lasted longer than the national and southern seasons reported by the Centers for Disease Control and Prevention. In addition, most seasons started earlier and ended later than the national and regional seasons. Considerable parallels were noted between RSV hospital admission frequency and number of RSV-positive tests, as determined by rapid antigen detection or viral culture. Taken together, these results reflect the clinical utility of RSV surveillance data and highlight the impact of RSV on infant hospitalization.
Replicative DNA Polymerase δ but Not ε Proofreads Errors in Cis and in Trans

It is now well established that in yeast, and likely most eukaryotic organisms, initial DNA replication of the leading strand is by DNA polymerase ε and of the lagging strand by DNA polymerase δ. However, the role of Pol δ in replication of the leading strand is uncertain. In this work, we use a reporter system in Saccharomyces cerevisiae to measure mutation rates at specific base pairs in order to determine the effect of heterozygous or homozygous proofreading-defective mutants of either Pol ε or Pol δ in diploid strains. We find that wild-type Pol ε molecules cannot proofread errors created by proofreading-defective Pol ε molecules, whereas Pol δ can not only proofread errors created by proofreading-defective Pol δ molecules, but can also proofread errors created by Pol ε-defective molecules. These results suggest that any interruption in DNA synthesis on the leading strand is likely to result in completion by Pol δ and also explain the higher mutation rates observed in Pol δ-proofreading mutants compared to Pol ε-proofreading defective mutants. For strains reverting via AT→GC, TA→GC, CG→AT, and GC→AT mutations, we find in addition a strong effect of gene orientation on mutation rate in proofreading-defective strains and demonstrate that much of this orientation dependence is due to differential efficiencies of mispair elongation. We also find that a 3′-terminal 8 oxoG, unlike a 3′-terminal G, is efficiently extended opposite an A and is not subject to proofreading. Proofreading mutations have been shown to result in tumor formation in both mice and humans; the results presented here can help explain the properties exhibited by those proofreading mutants.
Why Has Home Ownership Fallen Among the Young?

We document that home ownership of households with â€œheads\" aged 25-44 years fell substantially between 1980 and 2000 and recovered only partially during the 2001-2005 housing boom. The 1980-2000 decline in young home ownership occurred as improvements in mortgage opportunities made it easier to purchase a home. This paper uses an equilibrium life-cycle model calibrated to micro and macro evidence to understand why young home ownership fell over a period when it became easier to own a home. Our findings indicate that a trend toward marrying later and the increase in household earnings risk that occurred after 1980 account for 3/5 to 4/5 of the decline in young home ownership Keywords; housing, home ownership, tenure choice, first-time home-buyers, marriage, income risk
Swimming as a Positive Moderator of Cognitive Aging: A Cross-Sectional Study with a Multitask Approach

This study examined whether regular swimming in older adults was related to better cognitive functioning and whether there were any global or selective positive effects of this physical activity (PA) on cognition. The cognitive performances of three groups of sixteen volunteer participants (young adults, sedentary older adults, and older adults who regularly practice swimming) were evaluated using a multitask approach. All participants performed a battery of ten tasks: two reaction time tasks assessing information processing speed and eight experimental tasks assessing three executive functions (EFs), (behavioral inhibition, working memory updating, and cognitive flexibility). The results showed that young adults performed significantly better than older adults on all examined cognitive functions. However, in older adults, regular swimming was related to better performance on the three EFs, but not on information processing speed. More precisely, five experimental tasks out of the eight tapping EFs were shown to be sensitive to positive effects from swimming practice. Finally, the demonstrated benefits of swimming on EFs were not necessarily linked to better cardiorespiratory fitness. The present findings illustrate the validity of using a multitask approach in examining the potential benefits of regular PA on cognitive aging.
Ipilimumab administered to metastatic melanoma patients who progressed after dendritic cell vaccination

ABSTRACT Background: Ipilimumab has proven to be effective in metastatic melanoma patients. The purpose of this study was to determine the efficacy of ipilimumab in advanced melanoma patients who showed progressive disease upon experimental dendritic cell (DC) vaccination. Methods: Retrospective analysis of 48 stage IV melanoma patients treated with ipilimumab after progression upon DC vaccination earlier in their treatment. DC vaccination was given either as adjuvant treatment for stage III disease (n = 18) or for stage IV disease (n = 30). Ipilimumab (3 mg/kg) was administered every 3 weeks for up to 4 cycles. Results: Median time between progression upon DC vaccination and first gift of ipilimumab was 5.4 mo. Progression-free survival (PFS) rates for patients that received ipilimumab after adjuvant DC vaccination, and patients that received DC vaccination for stage IV melanoma, were 35% and 7% at 1 y and 35% and 3% at 2 y, while the median PFS was 2.9 mo and 3.1 mo, respectively. Median overall survival of patients pre-treated with adjuvant DC vaccination for stage III melanoma was not reached versus 8.0 mo (95% CI, 5.2–10.9) in the group pre-treated with DC vaccination for stage IV disease (HR of death, 0.36; p = 0.017). Grade 3 immune-related adverse events occurred in 19% of patients and one death (2%) was related to ipilimumab. Conclusions: Clinical responses to ipilimumab were found in a considerable number of advanced melanoma patients with progression after adjuvant DC vaccination for stage III disease, while the effect was very limited in patients who showed progression after DC vaccination for stage IV disease.
Finding Conceptual Document Clusters with Improved Top-N Formal Concept Search

In this paper, we discuss a method for conceptual clustering of documents. Our cluster is defined with the notion of formal concept analysis which can provide a conceptual meaning for each document cluster. Our clustering is formalized as a Top-N delta-valid formal concept problem. We improve our previous clique search-based algorithm for the problem so that it can be applied to larger scale datasets. For more efficient computation, we present some pruning rules based on theoretical properties of formal concepts. A depth-first branch-and-bound algorithm with the prunings is designed. Our experimental results show valuable clusters can be extracted from a collection of Web documents. Moreover, the algorithm outperforms some fast algorithms for mining closed itemsets equivalent to formal concepts
Simulating and Visualising Sedimentary Cluster-Cluster Aggregation

Recent simulations of di↵usion limited cluster-cluster aggregation (DLCA) have shown systematic inhomogeneities in the shape and orientation of clusters formed when a sedimentary force is applied. Using custom simulation and visualisation techniques and programs we have carried out a microscopic study of these sedimentary inhomogeneities and have mapped out the model parameter space. We find various transitional regimes in terms of the sedimentary Peclet number and identifiable time regimes for the growth behaviour of sedimenting clusters. We postulate some explanations based on the microscopic inhomogeneities of typical clusters grown under various conditions and illustrate the e↵ects with visual renderings and systems metrics.
A Miniaturized Dual-Band FSS With Second-Order Response and Large Band Separation

In this letter, a miniaturized dual-band frequency selective surfaces with second-order band-pass response at each operation band is presented. The design is implemented by cascading a two-dimensional periodic array of double square loops and an array of wire grids. The proposed structure composed of three metal and two dielectric layers acts as a spatial dual band microwave filter with large band separation. The predicted FSS has the merits of broadband response, excellent stability for different incident angles, and sharp roll-off at X- and Ka-band, respectively. The simulation and measurement are carried out and further discussed. A good agreement between simulated and measured results verifies the design of the dual-band FSS.
XRCC1 Arg399Gln and clinical outcome of platinum-based treatment for advanced non-small cell lung cancer: a meta-analysis in 17 studies

XRCC1 polymorphism is a research hotpot in individual treatment for non-small cell lung cancer (NSCLC). To obtain the association between XRCC1 polymorphism and clinical outcome of platinum-based treatment for NSCLC, a meta-analysis was conducted. Databases including PubMed, Embase, Cochrane, and Chinese National Knowledge Infrastructure (CNKI) were searched for publications that met the inclusion criteria. A fixed effect model was used to estimate pooled odds ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) for the association between XRCC1 Arg399Gln and response or survival of platinum-based treatment for advanced NSCLC. A chi-squared-based Q-test was used to test the heterogeneity hypothesis. Egger’s test was used to check publication bias. Seventeen published case-control studies that focus on the association between XRCC1 Arg399Gln and response or survival of platinum-based treatment for advanced NSCLC in 2 256 subjects were included in this meta-analysis, of whom 522 were AA genotypes (23.2% frequency), 916 AG genotypes (40.6% frequency), and 818 GG genotypes (36.2% frequency). The overall response rate (ORR) was 45.2% (110/243) for AA genotype patients, 29.9% for AG genotype (73/244), and 30.7% for GG genotype (124/403). The heterogeneity test did not show any heterogeneity and the Egger’s test did not reveal an obvious publication bias among the included studies. The meta-analysis indicated that AA genotype patients presented higher response rates toward platinum drug treatment compared with G model (GG+GA) patients (GG vs. AA model: OR=0.489, 95% CI 0.266–0.900, P=0.021; AG vs. AA model: OR=0.608, 95% CI 0.392–0.941, P=0.026; GA+AA vs. GG model: OR=1.259, 95% CI 0.931–1.701, P=0.135; GG+GA vs. AA model: OR=0.455, 95% CI 0.313–0.663, P=0.0001). However, no evidence validates XRCC1 associates with the survival following platinum drug therapy. Our meta-analysis suggested that XRCC1 Arg399Gln is related with the sensitivity of NSCLC patients to platinum-based treatment. AA genotype patients present more desirable curative effectiveness compared with other patients.
Self-Reported Sexual Identity, Sexual Behaviors and Health Risks

SUMMARY Data from a population-based survey of low-income young women (n = 2,438) was used to examine substance use patterns and exposure to coerced sexual activity among women who self-identify as lesbian (n = 34) or bisexual (n = 91), or who report sexual behavior exclusively with other women (n = 17) or with both women and men (n = 189). Findings for women classified by self-identity and by sexual behavior are compared. Women who identified as bisexual or lesbian reported higher rates of lifetime and recent substance use and were more likely to report experiences of coerced sex than women who identified as heterosexual. Women with both male and female sex partners reported higher rates of substance use and coerced sexual experiences than did women with male partners only. Heterosexual women with both male and female partners were more similar to self-identified bisexuals, compared to heterosexual women with male partners only. The implications of assessing multiple dimensions of sexual orientation in research focusing on lesbians' mental health are discussed.
Changes in cascading failure risk with generator dispatch method and system load level

Industry reliability rules increasingly require utilities to study and mitigate cascading failure risk in their system. Motivated by this, this paper describes how cascading failure risk, in terms of expected blackout size, varies with power system load level and pre-contingency dispatch. We used Monte Carlo sampling of random branch outages to generate contingencies, and a model of cascading failure to estimate blackout sizes. The risk associated with different blackout sizes was separately estimated in order to separate small, medium, and large blackout risk. Results from N − 1 secure models of the IEEE RTS case and a 2383 bus case indicate that blackout risk does not always increase with load level monotonically, particularly for large blackout risk. The results also show that risk is highly dependent on the method used for generator dispatch. Minimum cost methods of dispatch can result in larger long distance power transfers, which can increase cascading failure risk.
A structural model of alcohol use pathways among Latino youth.

OBJECTIVES To determine the pathways to alcohol use among adolescents. METHODS A cross-sectional study of risk and protective factors among a sample of Latino youth (aged 11-13) was conducted. RESULTS Peer norms and school connectedness had direct pathways to alcohol use. Self-concept was related to peer norms. Youth who were less acculturated were more likely to believe that their peers drank. Family monitoring, connectedness, and academic support did not have direct pathways to alcohol use. CONCLUSIONS Peer norms appear critical in shaping adolescent involvement with alcohol. The protective influence of family and academic support appear to be indirect.
Statistical physics of inference: thresholds and algorithms

Many questions of fundamental interest in today's science can be formulated as inference problems: some partial, or noisy, observations are performed over a set of variables and the goal is to recover, or infer, the values of the variables based on the indirect information contained in the measurements. For such problems, the central scientific questions are: Under what conditions is the information contained in the measurements sufficient for a satisfactory inference to be possible? What are the most efficient algorithms for this task? A growing body of work has shown that often we can understand and locate these fundamental barriers by thinking of them as phase transitions in the sense of statistical physics. Moreover, it turned out that we can use the gained physical insight to develop new promising algorithms. The connection between inference and statistical physics is currently witnessing an impressive renaissance and we review here the current state-of-the-art, with a pedagogical focus on the Ising model which, formulated as an inference problem, we call the planted spin glass. In terms of applications we review two classes of problems: (i) inference of clusters on graphs and networks, with community detection as a special case and (ii) estimating a signal from its noisy linear measurements, with compressed sensing as a case of sparse estimation. Our goal is to provide a pedagogical review for researchers in physics and other fields interested in this fascinating topic.
The Interaction between Saccharomyces cerevisiae and Non-Saccharomyces Yeast during Alcoholic Fermentation Is Species and Strain Specific

The present study analyzes the lack of culturability of different non-Saccharomyces strains due to interaction with Saccharomyces cerevisiae during alcoholic fermentation. Interaction was followed in mixed fermentations with 1:1 inoculation of S. cerevisiae and ten non-Saccharomyces strains. Starmerella bacillaris, and Torulaspora delbrueckii indicated longer coexistence in mixed fermentations compared with Hanseniaspora uvarum and Metschnikowia pulcherrima. Strain differences in culturability and nutrient consumption (glucose, alanine, ammonium, arginine, or glutamine) were found within each species in mixed fermentation with S. cerevisiae. The interaction was further analyzed using cell-free supernatant from S. cerevisiae and synthetic media mimicking both single fermentations with S. cerevisiae and using mixed fermentations with the corresponding non-Saccharomyces species. Cell-free S. cerevisiae supernatants induced faster culturability loss than synthetic media corresponding to the same fermentation stage. This demonstrated that some metabolites produced by S. cerevisiae played the main role in the decreased culturability of the other non-Saccharomyces yeasts. However, changes in the concentrations of main metabolites had also an effect. Culturability differences were observed among species and strains in culture assays and thus showed distinct tolerance to S. cerevisiae metabolites and fermentation environment. Viability kit and recovery analyses on non-culturable cells verified the existence of viable but not-culturable status. These findings are discussed in the context of interaction between non-Saccharomyces and S. cerevisiae.
Linear and conic programming estimators in high dimensional errors‐in‐variables models

We consider the linear regression model with observation error in the design. In this setting, we allow the number of covariates to be much larger than the sample size. Several new estimation methods have been recently introduced for this model. Indeed, the standard lasso estimator or Dantzig selector turns out to become unreliable when only noisy regressors are available, which is quite common in practice. In this work, we propose and analyse a new estimator for the errors‐in‐variables model. Under suitable sparsity assumptions, we show that this estimator attains the minimax efficiency bound. Importantly, this estimator can be written as a second‐order cone programming minimization problem which can be solved numerically in polynomial time. Finally, we show that the procedure introduced by Rosenbaum and Tsybakov, which is almost optimal in a minimax sense, can be efficiently computed by a single linear programming problem despite non‐convexities.