Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning Hierarchical Sparse Representations using Iterative Dictionary Learning and Dimension Reduction

This paper introduces an elemental building block which combines Dictionary Learning and Dimension Reduction (DRDL). We show how this foundational element can be used to iteratively construct a Hierarchical Sparse Representation (HSR) of a sensory stream. We compare our approach to existing models showing the generality of our simple prescription. We then perform preliminary experiments using this framework, illustrating with the example of an object recognition task using standard datasets. This work introduces the very first steps towards an integrated framework for designing and analyzing various computational tasks from learning to attention to action. The ultimate goal is building a mathematically rigorous, integrated theory of intelligence.
An Investigation of the Determinants of Stigmatization and Prejudice Toward People Living With HIV/AIDS

The components and determinants of HIV/AIDS stigma and prejudice were investigated in an online-questionnaire study. The results show that the components of the attitude toward people with HIV/AIDS consist of social distance, demands for political measures, negative stereotypes, and attribution of responsibility to people living with HIV/AIDS. Besides anti-gay attitudes and false beliefs about ways of infection, the HIV/AIDS attitude is connected to and depends on social dominance orientation (SDO) and right-wing authoritarianism (RWA). Structural equation modeling indicated that anti-gay attitudes and false beliefs function as mediator variables for SDO and RWA. Implications of the results are discussed. jasp_638 1747.1767 Chronic diseases, such as AIDS, leprosy, diabetes, hypertension, and pain present an enormous socioeconomic burden to society, yet the magnitude of stigma attached to these diseases differs widely. This paper looks at the reasons for this difference by identifying the underlying factors responsible for stigmatization attached to HIV/AIDS.
Growth factors bFGF and TGB beta accelerate the rate of wound repair in normal and in diabetic rats.

The effects of basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF beta) on the rate of wound repair in both normal and streptozotocin-induced diabetic rats were investigated using two model systems of wound repair, namely incisional wounding and subcutaneous implantation of polyvinyl alcohol (PVA) sponges. Both models showed the expected wound-healing defects of the diabetic rats. Granulation tissue collected from the implanted PVA sponges showed that the diabetic rats had reduced amounts of collagen, DNA and protein present at the wound site at two time points tested (7 and 9 days post-implantation). Fresh tensile strength of the incisional wounds, a measure of the collagen organization in a wound, was reduced to 53% of normal in diabetic rats on day 7 post-wounding, and was only 29% of normal by day 21. Formalin-fixed tensile strength, a measure of collagen content of the wound, was 41% of normal on day 7, and 78% of normal by day 21, giving evidence that while the collagen concentration of the diabetic wounds approached that of normal wounds, it did not undergo the normal maturation process. A single injection of 2 micrograms of TGF beta directly into the incision three days after wounding resulted in little difference in the fresh and fixed tensile strength of diabetic wounds when tested at 7, 14 and 21 days post-wounding. Normal rats, however, responded well, resulting in a greater than 30% increase in both fresh and fixed tensile strength. (ABSTRACT TRUNCATED AT 250 WORDS)
Speed accuracy trade-off under response deadlines

Perceptual decision making has been successfully modeled as a process of evidence accumulation up to a threshold. In order to maximize the rewards earned for correct responses in tasks with response deadlines, participants should collapse decision thresholds dynamically during each trial so that a decision is reached before the deadline. This strategy ensures on-time responding, though at the cost of reduced accuracy, since slower decisions are based on lower thresholds and less net evidence later in a trial (compared to a constant threshold). Frazier and Yu (2008) showed that the normative rate of threshold reduction depends on deadline delays and on participants' uncertainty about these delays. Participants should start collapsing decision thresholds earlier when making decisions under shorter deadlines (for a given level of timing uncertainty) or when timing uncertainty is higher (for a given deadline). We tested these predictions using human participants in a random dot motion discrimination task. Each participant was tested in free-response, short deadline (800 ms), and long deadline conditions (1000 ms). Contrary to optimal-performance predictions, the resulting empirical function relating accuracy to response time (RT) in deadline conditions did not decline to chance level near the deadline; nor did the slight decline we typically observed relate to measures of endogenous timing uncertainty. Further, although this function did decline slightly with increasing RT, the decline was explainable by the best-fitting parameterization of Ratcliff's diffusion model (Ratcliff, 1978), whose parameters are constant within trials. Our findings suggest that at the very least, typical decision durations are too short for participants to adapt decision parameters within trials.
Seroprevalence of Helicobacter pylori infection in Nepal: low prevalence in an isolated rural village

Objective To determine the seroprevalence of Helicobacter pylori infection in Nepal. Design H. pylori infection was identified using a specific and sensitive enzyme-linked immunosorbent assay for anti-H. pylori immunoglobulin G. Study population Serum samples were collected from 1142 inhabitants (age range 4–93 years) from two villages: Kotyang, a rural isolated village (250 men, 210 women) and Bhadrakali, a suburban village of Kathmandu (334 men, 348 women). Results The overall prevalence of H. pylori infection was 56.8%, while a significantly higher prevalence was found in the suburban village (Bhadrakali; 67.2%) than in the rural village (Kotyang; 41.5%). This difference was generally reflected by the infection rate in the 10–14-year-old age-group (Bhadrakali, 60% compared with Kotyang, 22.2%). The prevalence of infection significantly increased with age, while no significant difference was found in the prevalence of infection by gender. There was no difference in H. pylori positivity between individuals with and without upper abdominal symptoms in both villages. Conclusion There was a significant regional difference in the seroprevalence of H. pylori within Nepal, which showed lower prevalence in an isolated rural village. This difference was mainly caused by the different acquisition rate in teenagers, thus indicating that the teenage lifestyle of this particular environment seemed to be the major determinant in the acquisition of H. pylori infection in the population.
The Neural Bases of Strategy and Skill in Sentence–Picture Verification

This experiment used functional Magnetic Resonance Imaging to examine the relation between individual differences in cognitive skill and the amount of cortical activation engendered by two strategies (linguistic vs. visual-spatial) in a sentence-picture verification task. The verbal strategy produced more activation in language-related cortical regions (e.g., Broca's area), whereas the visual-spatial strategy produced more activation in regions that have been implicated in visual-spatial reasoning (e.g., parietal cortex). These relations were also modulated by individual differences in cognitive skill: Individuals with better verbal skills (as measured by the reading span test) had less activation in Broca's area when they used the verbal strategy. Similarly, individuals with better visual-spatial skills (as measured by the Vandenberg, 1971, mental rotation test) had less activation in the left parietal cortex when they used the visual-spatial strategy. These results indicate that language and visual-spatial processing are supported by partially separable networks of cortical regions and suggests one basis for strategy selection: the minimization of cognitive workload.
Robust Low-Rank Subspace Segmentation with Semidefinite Guarantees

Recently there is a line of research work proposing to employ Spectral Clustering (SC) to segment (group)\footnote{Throughout the paper, we use segmentation, clustering, and grouping, and their verb forms, interchangeably. } high-dimensional structural data such as those (approximately) lying on subspaces\footnote{We follow~\cite{liu2010robust} and use the term ``subspace'' to denote both linear subspaces and affine subspaces. There is a trivial conversion between linear subspaces and affine subspaces as mentioned therein. } or low-dimensional manifolds. By learning the affinity matrix in the form of sparse reconstruction, techniques proposed in this vein often considerably boost the performance in subspace settings where traditional SC can fail. Despite the success, there are fundamental problems that have been left unsolved: the spectrum property of the learned affinity matrix cannot be gauged in advance, and there is often one ugly symmetrization step that post-processes the affinity for SC input. Hence we advocate to enforce the symmetric positive semi definite constraint explicitly during learning (Low-Rank Representation with Positive Semi Definite constraint, or LRR-PSD), and show that factually it can be solved in an exquisite scheme efficiently instead of general-purpose SDP solvers that usually scale up poorly. We provide rigorous mathematical derivations to show that, in its canonical form, LRR-PSD is equivalent to the recently proposed Low-Rank Representation (LRR) scheme~\cite{liu2010robust}, and hence offer theoretic and practical insights to both LRR-PSD and LRR, inviting future research. As per the computational cost, our proposal is at most comparable to that of LRR, if not less. We validate our theoretic analysis and optimization scheme by experiments on both synthetic and real data sets.
Influence of Self-presentation on Bridging Social Capital in SNSs: A Moderating Effect of Self-presentation

Social networking sites (SNSs) by and large have deeply penetrated in the daily routine of internet users, where they can articulate their social relations and manage their profiles to present themselves. SNSs users engage heavily in self-presentation strategies by keeping their profile updated regularly, which prompted this study to examine how far it impacts on bridging social capital. This paper provides an understanding that self-presentation of the owner of a profile has impact on the bridging social capital. In this connection, a self administered survey was carried out at Huanzhong University of Science and Technology, Wuhan, China on the sample size of 199 (N=199) students. Findings of the study showed that the self-presentation have strong moderating impact on the relationship of SNSs usage and bridging social capital, suggesting that an effective self-presentation on SNSs by users does indeed help them in bridging social capital on SNSs. Keywords: Self-presentation, bridging social capital, impression management, social networking sites, moderator.
Evidence-based guideline summary: Evaluation, diagnosis, and management of congenital muscular dystrophy: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medici

Editors’ Note: In WriteClick this week, Haliloglu and Topaloglu comment on “Evidence-based guideline summary: Evaluation, diagnosis, and management of congenital muscular dystrophy,” and authors Kang et al. answer their points, noting that the guideline generally based its statements on the articles with the best methodology. Dr. Bronstein challenges the conclusion in “Neuropsychological outcome after deep brain stimulation for Parkinson disease” that the subthalamic nucleus is the preferred target in deep brain stimulation over the globus pallidus pars interna. Authors Odekerken et al. summarize their supporting data. It is clear that the matter may not yet be settled. —Megan Alcauskas, MD, and Robert C. Griggs, MD
Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer

Myeloid zinc finger 1 (MZF1) belongs to the SCAN‐Zinc Finger (SCAN‐ZF) transcription factor family that has recently been implicated in a number of types of cancer. Although the initial studies concentrated on the role of MZF1 in myeloid differentiation and leukemia, the factor now appears to be involved in the etiology of major solid tumors such as lung, cervical, breast, and colorectal cancer. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation, formation of promyelocytic leukemia nuclear bodies and its association with co‐activators and co‐repressors. J. Cell. Biochem. 116: 2146–2154, 2015. © 2015 Wiley Periodicals, Inc.
Detecting non-uniform period spacings in the Kepler photometry of γ Doradus stars: methodology and case studies

Context. The analysis of stellar oscillations is one of the most reliable ways to probe stellar interiors. Recent space missions such as Kepler have provided us with an opportunity to study these oscillations with unprecedented detail. For many multi-periodic pulsators such as {\gamma} Doradus stars, this led to the detection of dozens to hundreds of oscillation frequencies that could not be found from ground-based observations. Aims. We aim to detect non-uniform period spacings in the Fourier spectra of a sample of {\gamma} Doradus stars observed by Kepler. Such detection is complicated by both the large number of significant frequencies in the space photometry and by overlapping non-equidistant rotationally split multiplets. Methods. Guided by theoretical properties of gravity-mode oscillation of {\gamma} Doradus stars, we developed a period-spacing detection method and applied it to Kepler observations of a few stars, after having tested the performance from simulations. Results. The application of the technique resulted in the clear detection of non-uniform period spacing series for three out of the five treated Kepler targets. Disadvantages of the technique are also discussed, and include the disability to distinguish between different values of the spherical degree and azimuthal order of the oscillation modes without additional theoretical modelling. Conclusions. Despite the shortcomings, the method is shown to allow solid detections of period spacings for {\gamma} Doradus stars, which will allow future asteroseismic analyses of these stars.
Information cascades in online reading: an empirical investigation of panel data

Purpose – The purpose of this paper is to examine information cascades in the context of users’ e-book reading behavior and differentiate it from alternative factors that lead to herd behavior, such as network externalities and word-of-mouth effects. Design/methodology/approach – This paper constructed panel data using information concerning 226 e-books in 30 consecutive days from Sina.com’s reading channel (Book.Sina.com.cn) from October 2, 2013, to October 31, 2013 of the same year in China. A multinomial logit market-share model was employed. Findings – E-books’ ranking has a significant impact on their market share, as predicted by informational cascades theory. Higher ranking e-books’ clicks will see a greater increase as a result of an increase in clicks ranking. Due to the information cascades effect, review volume had no impact on the market share of popular e-books. Total votes had a powerful impact on the market share of e-books, showing that once information cascade occurred, it could be enhanc.
Pharmacological Modulation of Sarcoplasmic Reticulum Function in Smooth Muscle

The sarco/endoplasmic reticulum (SR/ER) is the primary storage and release site of intracellular calcium (Ca2+) in many excitable cells. The SR is a tubular network, which in smooth muscle (SM) cells distributes close to cellular periphery (superficial SR) and in deeper aspects of the cell (deep SR). Recent attention has focused on the regulation of cell function by the superficial SR, which can act as a buffer and also as a regulator of membrane channels and transporters. Ca2+ is released from the SR via two types of ionic channels [ryanodine- and inositol 1,4,5-trisphosphate-gated], whereas accumulation from thecytoplasm occurs exclusively by an energy-dependent sarco-endoplasmic reticulum Ca2+-ATPase pump (SERCA). Within the SR, Ca2+ is bound to various storage proteins. Emerging evidence also suggests that the perinuclear portion of the SR may play an important role in nuclear transcription. In this review, we detail the pharmacology of agents that alter the functions of Ca2+ release channels and of SERCA. We describe their use and selectivity and indicate the concentrations used in investigating various SM preparations. Important aspects of cell regulation and excitation-contractile activity coupling in SM have been uncovered through the use of such activators and inhibitors of processes that determine SR function. Likewise, they were instrumental in the recent finding of an interaction of the SR with other cellular organelles such as mitochondria. Thus, an appreciation of the pharmacology and selectivity of agents that interfere with SR function in SM has greatly assisted in unveiling the multifaceted nature of the SR.
Effect of Low-Dose Perindopril/Indapamide on Albuminuria in Diabetes: Preterax in Albuminuria Regression: PREMIER

Abstract—Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril monotherapy on albumin excretion rate (AER) in patients with type 2 diabetes, albuminuria, and hypertension in a 12-month, randomized, double-blind, parallel-group international multicenter study. Four hundred eighty-one patients with type 2 diabetes and hypertension (systolic BP ≥140 mm Hg, <180 mm Hg, diastolic BP <110 mm Hg) were randomly assigned (age 59±9 years, 77% previously treated for hypertension). Results from 457 patients (intention-to-treat analysis) were available. After a 4-week placebo period, patients with albuminuria >20 and <500 &mgr;g/min were randomly assigned to a combination of 2 mg perindopril/0.625 mg indapamide or to 10 mg daily enalapril. After week 12, doses were adjusted on the basis of BP to a maximum of 8 mg perindopril/2.5 mg indapamide or 40 mg enalapril. The main outcome measures were overnight AER and supine BP. Both treatments reduced BP. Perindopril/indapamide treatment resulted in a statistically significant higher fall in both BP (−3.0 [95% CI −5.6, −0.4], P =0.012; systolic BP −1.5 [95% CI −3.0, −0.1] diastolic BP P =0.019) and AER −42% (95% CI −50%, −33%) versus −27% (95% CI −37%, −16%) with enalapril. The greater AER reduction remained significant after adjustment for mean BP. Adverse events were similar in the 2 groups. Thus, first-line treatment with low-dose combination perindopril/indapamide induces a greater decrease in albuminuria than enalapril, partially independent of BP reduction. A BP-independent effect of the combination may increase renal protection.
Vitamin D and Cardiovascular Disease

The hormonal derivative of vitamin D, 1,25‐dihydroxyvitamin D (1,25[OH]2D) or calcitriol, has been implicated in many physiologic processes beyond calcium and phosphorus homeostasis, and likely plays a role in several chronic disease states, in particular, cardiovascular disease. Experimental data suggest that 1,25(OH)2D affects cardiac muscle directly, controls parathyroid hormone secretion, regulates the renin‐angiotensin‐aldosterone system, and modulates the immune system. Because of these biologic effects, vitamin D deficiency has been associated with hypertension, several types of vascular diseases, and heart failure. We conducted a MEDLINE search of the English‐language literature (1950–2008) to identify studies that examined these relationships; additional citations were obtained from the articles retrieved from the literature search. Treatment with vitamin D lowered blood pressure in patients with hypertension and modified the cytokine profile in patients with heart failure. Measurement of serum 25‐hydroxyvitamin D concentration usually provides the best assessment of an individual's vitamin D status. Serum levels below 20 ng/ml represent vitamin D deficiency, and levels above 30 ng/ml are considered optimal. Although the observational data linking vitamin D status to cardiovascular disease appear robust, vitamin D supplementation is not recommended as routine treatment for heart disease until definitive prospective, randomized trials can be carried out to assess its effects. However, such supplementation is often appropriate for other reasons and may be beneficial to cardiovascular health in certain patients.
Tuning and controlling gene expression noise in synthetic gene networks

Synthetic gene networks can be used to control gene expression and cellular phenotypes in a variety of applications. In many instances, however, such networks can behave unreliably due to gene expression noise. Accordingly, there is a need to develop systematic means to tune gene expression noise, so that it can be suppressed in some cases and harnessed in others, e.g. in cellular differentiation to create population-wide heterogeneity. Here, we present a method for controlling noise in synthetic eukaryotic gene expression systems, utilizing reduction of noise levels by TATA box mutations and noise propagation in transcriptional cascades. Specifically, we introduce TATA box mutations into promoters driving TetR expression and show that these mutations can be used to effectively tune the noise of a target gene while decoupling it from the mean, with negligible effects on the dynamic range and basal expression. We apply mathematical and computational modeling to explain the experimentally observed effects of TATA box mutations. This work, which highlights some important aspects of noise propagation in gene regulatory cascades, has practical implications for implementing gene expression control in synthetic gene networks.
The public sphere according to UK stem cell scientists

In this thesis the concept of social representations is made relevant to the study of the ‘public sphere’ according to scientists. This is elaborated by the re-examination of the notion of a ‘consensual’ and a ‘reified universe’ substantiating a more sociopsychological approach in the study of relevant phenomena. Two processes generate social representations of the public: anchoring and objectification. The empirical study investigates the scientists’ views of the public sphere, in relation to public perceptions, media coverage and the regulation of cloning technology. Elite media coverage of the stem cell debate and conversations with stem cell scientists are systematically analysed with multiple methods. Findings are based on 461 news articles that appeared in Nature and Science between 1997 and 2005 and on interviews with 18 U.K based stem cell researchers conducted between February and October 2005. The analysis compares the debate before and after the ‘stem cell war’ of 2002, and typifies a high tension in representing the public sphere, elaborated in metaphors and prevailing arguments. Central elements of the representation assume a strong disassociation of science from the public sphere; peripheral elements operate with a degree of blurring of those same boundaries, which recognises a common project. This representation, while being expressive of its context of production, constitutes a functional response to it.