Miracle-dz/UniFAR-FTUs huggingface dataset:
L'impact des stimuli informationnels d'un nouveau produit alimentaire sur les réactions affectives et cognitives du consommateur

L'objectif de cet article est de montrer l'influence simultanée de l'innovation produit (complémentarité de l'arôme) et de l'innovation packaging (design du produit à travers la prototypicalité du contenant et la quantité d'informations sur l'étiquette) lors du lancement d'une nouvelle boisson alcoolisée aromatisée. Ces éléments sont testés par le biais d'une expérimentation invitant 383 individus à évaluer la pertinence du mélange proposé, la nouveauté perçue de la boisson et leurs inférences en matière de goût (caractère sucré, douceur et intensité). Nous examinons en outre le rôle médiateur de ces variables sur l'agrément et celui de l'agrément sur l'intention de goûter le nouveau produit alimentaire. Les résultats confirment que la complémentarité de l'arôme influence positivement la pertinence perçue du mélange et négativement sa nouveauté perçue. L'analyse permet également d'identifier une relation linaire entre pertinence perçue et agrément alors que la relation entre nouveauté perçue et agrément suit une tendance quadratique (courbe en u).
The Contributory Role of Angiotensin Receptor-Like 1 Gene Multiple Polymorphisms in Hypertension among Northeastern Han Chinese

Background and Objective Via direct sequencing, we have recently identified six common polymorphisms in angiotensin receptor-like 1 (AGTRL1) gene, and found only two polymorphisms were significantly associated with hypertension in a family-based analysis on 1,015 southern Han Chinese. Extending our previous work and considering the ubiquity of epistasis in determining disease susceptibility, we, in this study, sought to explore the potential interaction of AGTRL1 gene six polymorphisms with hypertension in a large northeastern Han Chinese population. Methods and Results This was a case-control study involving 1,009 sporadic hypertensive patients and 756 normotensive controls. Data were analyzed by Haplo.Stats and multifactor dimensionality reduction (MDR) softwares. There were no deviations from Hardy-Weinberg equilibrium for all polymorphisms. The genotypes and alleles of rs7119675 and rs11544374 differed significantly between the two groups (P<0.0005), even after the Bonferroni correction. Under three genetic models, significant association was consistently observed for rs7119675 and rs11544374, and this association was independent of confounding factors. Taking rs7119375 as an example, the odds of having hypertension was 2.46 (95% confidence interval (95% CI): 2.06–2.94), 2.82 (95% CI: 2.29–3.46) and 3.97 (95% CI: 2.37–6.64) under additive, dominant and recessive models (P<0.001), respectively, whereas the adjusted risk estimates were slightly attenuated but still significant. The frequencies of most derived haplotypes differed significantly between patients and controls. Haplotype-phenotype analyses indicated marginal association for triglyceride (PSim = 0.011) and total cholesterol (PSim = 0.025) in patients and for triglyceride in controls (PSim = 0.023). The overall best MDR model included rs11544374, rs7119375 and rs948847 with the maximal testing accuracy of 0.737 and cross-validation consistency of 10 out of 10 (P<0.0001). Further interaction entropy graph suggested that the interaction of rs7119375 with rs11544374 and rs948847 was strongly antagonized. Conclusions Our findings demonstrate that AGTRL1 genetic polymorphisms might contribute to the development of hypertension independently and/or through complex interaction.
Market arbitrage, social choice and the core

Abstract. This paper establishes a clear connection between equilibrium theory, game theory and social choice theory by showing that, for a well defined social choice problem, a condition which is necessary and sufficient to solve this problem – limited arbitrage – is the same as the condition which is necessary and sufficient to establish the existence of an equilibrium and the core. The connection is strengthened by establishing that a market allocation, which is in the core, can always be realized as a social allocation, i.e. an allocation which is optimal according to an ordering chosen by a social choice rule. Limited arbitrage characterizes those economies without Condorcet triples, and those for which Arrow’s paradox can be resolved on choices of large utility values.
A Simple Scoring System Predicting the Survival Time of Patients with Bone Metastases after RT

Objectives This study aimed to develop a scoring system to predict the survival time of patients with bone metastases after radiation therapy (RT). The scoring system can guide physicians to a better selection of appropriate treatment regimens. Materials and Methods The medical records of 125 patients with bone metastases treated with RT between January 2007 and September 2010 were reviewed retrospectively. Fifteen potential prognostic factors were investigated: sex, age, Karnofsky performance score (KPS), type of primary tumor, resection of tumor before bone metastases, interval between primary tumor diagnosis and diagnosis of bone metastases, Carcinoembryonic Antigen(CEA), lung metastases before bone metastases, liver metastases before bone metastases, brain metastases before bone metastases, stage, T, N, M, and degree of cellular differentiation. Results In an univariate analysis, 10 factors were significantly associated with survival time after bone metastasis: sex, KPS, breast cancer, esophageal cancer, colorectal cancer, interval between tumor diagnosis and diagnosis of bone metastases, CEA, lung metastases before bone metastases, T-staging, and differentiation. In a multivariate analysis, 7 factors were found to be significant: sex, KPS, esophageal cancer, colorectal cancer, interval between tumor diagnosis and diagnosis of bone metastases, T-staging, and differentiation. The median survival of all patients with bone metastases after RT was 14.1 months. There were significant differences in the median survival of patients with bone metastases after RT of 4.9 months, 10.5 months, and 29.7 months in groups 1, 2, and 3, respectively (P<0.001). Conclusion According to this scoring system, the survival time of patients after bone metastasis can be estimated.
Effects of duloxetine, a new serotonin and norepinephrine uptake inhibitor, on extracellular monoamine levels in rat frontal cortex.

The effects of duloxetine (LY248686), a new inhibitor of serotonin (5-hydroxytryptamine; 5-HT) and norepinephrine (NE) uptake on extracellular levels of NE, 5-HT and dopamine (DA), were studied in the rat frontal cortex and nucleus accumbens, using in vivo microdialysis. The oral administration of duloxetine (3.125-12.5 mg/kg) produced a dose-dependent increase in the output of both NE and 5-HT from the frontal cortex, this increase being maintained throughout the 4-hr observation period. Chronic administration of duloxetine (6.25 mg/kg, p.o.) for 14 days failed to alter basal NE and 5-HT levels in the frontal cortex, but augmented the duloxetine-induced increase in output of NE and 5-HT. Amitriptyline and maprotiline, administered p.o. at doses of 6.25 to 25 mg/kg, increased NE output, but the effect was weaker than that of duloxetine, and neither amitriptyline nor maprotiline changed 5-HT output from the frontal cortex. Duloxetine, amitriptyline, and maprotiline brought about increases in DA levels in the rat frontal cortex, the increase in DA levels induced by duloxetine being approximately two or three times more potent than that induced by amitriptyline and maprotiline. In the nucleus accumbens, duloxetine also produced a dose-dependent increase in DA output more potent than that produced by amitriptyline and maprotiline. These results show that duloxetine causes a potent and sustained increase in the output of both NE and 5-HT in the rat frontal cortex, related to its inhibition of NE and 5-HT uptake; these results also show that duloxetine increases DA output in the frontal cortex.
The effect of brain state on rapid auditory processing in the rat

by Liad Hollender A Dissertation submitted to the Graduate School-Newark Rutgers, The State University of New Jersey in partial fulfillment of the requirements for the degree of Doctor of Philosophy Graduate Program in Integrative Neuroscience written under the direction of Kenneth D Harris and approved by ________________________ ________________________ ________________________ ________________________ Newark, New Jersey
STIM1-Directed Reorganization of Microtubules in Activated Mast Cells

Activation of mast cells by aggregation of the high-affinity IgE receptors (FcεRI) initiates signaling events leading to the release of inflammatory and allergic mediators stored in cytoplasmic granules. A key role in this process play changes in concentrations of intracellular Ca2+ controlled by store-operated Ca2+ entry (SOCE). Although microtubules are also involved in the process leading to degranulation, the molecular mechanisms that control microtubule rearrangement during activation are largely unknown. In this study, we report that activation of bone marrow-derived mast cells (BMMCs) induced by FcεRI aggregation or treatment with pervanadate or thapsigargin results in generation of protrusions containing microtubules (microtubule protrusions). Formation of these protrusions depended on the influx of extracellular Ca2+. Changes in cytosolic Ca2+concentration also affected microtubule plus-end dynamics detected by microtubule plus-end tracking protein EB1. Experiments with knockdown or reexpression of STIM1, the key regulator of SOCE, confirmed the important role of STIM1 in the formation of microtubule protrusions. Although STIM1 in activated cells formed puncta associated with microtubules in protrusions, relocation of STIM1 to a close proximity of cell membrane was independent of growing microtubules. In accordance with the inhibition of Ag-induced Ca2+ response and decreased formation of microtubule protrusions in BMMCs with reduced STIM1, the cells also exhibited impaired chemotactic response to Ag. We propose that rearrangement of microtubules in activated mast cells depends on STIM1-induced SOCE, and that Ca2+ plays an important role in the formation of microtubule protrusions in BMMCs.
A controlled, class‐based multicomponent intervention to promote healthy lifestyle and to reduce the burden of childhood obesity

What is already known about this subject Overweight and obesity prevention in childhood and adolescence represent a priority target for public health. Scientific literature recommends multidisciplinary (multicomponent) interventions in order to modify the time trend of childhood obesity and the school is considered one of the most favourable settings. Children in the age range 8 to 10 (end of primary school) already have preferences on food choices and physical activity, but they still are susceptible to change in response to positive reinforcement by parents, teachers, friends and schoolmates. The strategy of empowering parents during intervention by telephone calls, following an intense motivational programme, to stimulate adherence to physical activity targets and to remove barriers has been receiving increased attention.
Nonsteroidal Anti-inflammatory Drugs and Glioma in the NIH-AARP Diet and Health Study Cohort

Several case–control studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce risk for glioblastoma, an aggressive form of brain cancer. Prospective investigations have not observed such an association, but these studies lacked adequate brain cancer case numbers and did not stratify by histologic subtype. We prospectively investigated the association between NSAID use and risk of all glioma as well as the risk of glioblastoma subtype in the National Institutes of Health (NIH)-AARP Diet and Health Study. The frequency of aspirin and nonaspirin NSAID use 1 year prior to baseline was ascertained using a self-administered questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using Cox regression models with age as the underlying time metric, adjusted for sex, race, and history of heart disease. The analysis included 302,767 individuals, with 341 incident glioma cases (264 glioblastoma). No association was observed between regular use (>2 times/wk) of aspirin and risk of glioma (HR = 1.16; 95% CI, 0.87–1.56) or glioblastoma (HR = 1.17; 95% CI, 0.83–1.64) as compared with no use. Null associations were also observed for nonaspirin NSAID use (HR for glioma = 0.90; 95% CI, 0.65–1.25 and HR for glioblastoma = 0.83; 95% CI, 0.56–1.20) as compared with no use. Our findings from this large prospective study do not support an inverse association between NSAIDs and risk of all glioma or glioblastoma. Cancer Prev Res; 4(12); 2027–34. ©2011 AACR.
Mycobacterium tuberculosis Type II NADH-Menaquinone Oxidoreductase Catalyzes Electron Transfer through a Two-Site Ping-Pong Mechanism and Has Two Quinone-Binding Sites

Type II NADH-quinone oxidoreductase (NDH-2) catalyzes the transfer electrons from NADH to the quinone pool and plays an essential role in the oxidative phosphorylation system of Mycobacterium tuberculosis (Mtb). The absence of NDH-2 in the mammalian mitochondrial electron transport chain makes this enzyme an attractive target for antibiotic development. To fully establish the kinetic properties of this enzyme, we studied the interaction of Mtb NDH-2 with substrates, NADH, and various quinone analogues and their products in both membrane and soluble environments. These studies, and comparative analyses of the kinetics with thio-NAD+ and quinone electron acceptors, provided evidence that Mtb NDH-2 catalyzes the transfer electrons from NADH to quinone substrates by a nonclassical, two-site ping-pong kinetic mechanism whereby substrate quinones bind to a site that is distinct from the NADH-binding site. Furthermore, the effects of quinols on Mtb NDH-2 catalytic activity demonstrate the presence of two binding sites for quinone ligands, one favoring the reduced form and the other favoring the oxidized form.
An adaptive output feedback motion tracking controller for robot manipulators: Uniform global asymptotic stability and experimentation

Abstract This paper deals with two important practical problems in motion control of robot manipulators: the measurement of joint velocities, which often results in noisy signals, and the uncertainty of parameters of the dynamic model. Adaptive output feedback controllers have been proposed in the literature in order to deal with these problems. In this paper, we prove for the first time that Uniform Global Asymptotic Stability (UGAS) can be obtained from an adaptive output feedback tracking controller, if the reference trajectory is selected in such a way that the regression matrix is persistently exciting. The new scheme has been experimentally implemented with the aim of confirming the theoretical results.
Firm Heterogeneity in Capital-Labour Ratios and Wage Inequality

This paper provides some empirical evidence and a theory of the relationship between residual wage inequality and the increasing dispersion of capital/labor ratios across firms. I document the increasing variance of capital/labor ratios across firms in the US labor market. I also show that the increase in the capital intensity variance across firms is associated with the increasing wage variance across workers. To explain this empirical fact, I adopt a search model where firms differ in their optimal capital investment. The decline in the relative price of equipment capital makes the firm distribution of capital/labor ratios more dispersed. In a frictional labor market, this force generates wage dispersion among identical workers. Simple calibration of the model indicates that the dispersion of capital/labor ratios can account for about one third of the total increase in residual wage inequality.
Fertilizing capacity of bovine spermatozoa selected after swim-up in hyaluronic acid-containing medium.

Hyaluronic acid (HA) was used to select spermatozoa from frozen-thawed semen from five bulls; two were highly fertile and three had low fertility related to low post-thaw motility of the spermatozoa. Spermatozoa were collected after 1 h of self-migration in one of two media: a modified Tyrode's lactate solution (TALP) or a medium consisting of equal volumes of TALP and phosphate-buffered saline to which HA was added to obtain a final concentration of 1 mg mL-1 (HA medium). The selected spermatozoa were used to inseminate oocytes matured in vitro at a concentration of either 1.0 x 10(6) or 0.5 x 10(6) mL-1, constituting a 5 x 2 x 2 factorial experiment. After 19-22 h of sperm-oocyte co-incubation, fertilization of oocytes was assessed. The two concentrations of spermatozoa differed significantly in the percentage of oocytes penetrated (P = 0.001) and the percentage of oocytes with two pronuclei (P = 0.002). When 1.0 x 10(6) mL-1 spermatozoa were used, spermatozoa collected after swim-up in the HA medium fertilized more oocytes (P = 0.01) than did those collected after swim-up in TALP. Variation between bulls was also significant (P = 0.002). The beneficial effect of the HA medium was more evident in the group of low-fertility bulls (P < or = 0.03), where neither the variation between bulls (P > or = 0.06) nor the interaction between the methods of sperm selection and bulls (P > or = 0.10) was significant. (ABSTRACT TRUNCATED AT 250 WORDS)
Splenic inflammatory myofibroblastic tumor (inflammatory pseudotumor): a clinicopathologic and immunophenotypic study of 12 cases.

CONTEXT Inflammatory pseudotumor is an uncommon and enigmatic lesion. The spindle cells found in this tumor have features of myofibroblasts. Because of the indefinite relationship of these lesions with inflammatory fibrosarcoma and their indefinite biologic behavior, inflammatory pseudotumor is currently classified as inflammatory myofibroblastic tumor (IMT). To date, only case reports or small series have been published on these tumors, which are primary in the spleen. DESIGN In this study, we describe the clinical, morphologic, and immunophenotypic findings of 12 cases of splenic IMT and examine their relationship to Epstein-Barr virus (EBV). RESULTS The patients included 8 women and 3 men, ranging from 19 to 77 years of age (mean, 53 years; median, 60 years). Demographic data were unavailable for 1 patient. Patients generally presented with abdominal pain (n = 5) and fever (n = 4). Associated lesions included renal cell carcinoma (n = 2), colonic adenocarcinoma (n = 1), and cholecystitis (n = 1). All tumors were composed of a bland spindle cell proliferation in association with a variable mixed inflammatory component. There were 2 growth patterns, namely, a cellular spindle cell pattern and a hypocellular fibrous pattern. An immunohistochemical panel confirmed the myofibroblastic nature of the spindle cells. The spindle cells of 2 cases were immunoreactive for EBV latent membrane protein 1, whereas 6 of 10 cases were positive for EBV-encoded RNA using in situ hybridization. Follow-up was available for 8 patients; 6 were alive with no evidence of recurrence and 2 were dead of other causes. CONCLUSION Splenic IMTs are uncommon lesions that can be distinguished from other conditions using a combination of clinical, histologic, and immunophenotypic findings. Epstein-Barr virus may play a role in the pathogenesis of splenic IMT, and there may be an association of splenic IMT with concomitant disease or malignancy. Most splenic IMTs have an excellent long-term prognosis.
Sonication cultures of explanted components as an add‐on test to routinely conducted microbiological diagnostics improve pathogen detection

The purpose of this study was to improve the pathogen detection in prosthetic joint infections, particularly to evaluate the feasibility of the sonication culture method in the clinical routine. Explanted components of all patients with presumptive prosthetic or implant infection were sonicated separately in sterile containers to dislodge the adherent bacteria from the surfaces and cultured. The results of sonication culture were compared to the conventional tissue culture. We investigated 60 consecutive patients with loosening of the prostheses or implants Forty patients had septic and 20 aseptic loosening (24 knee prostheses, 21 hip prostheses, 6 mega‐prostheses, 2 shoulder prostheses, 6 osteosynthesis, 1 spinal instrumentation). The sensitivity of sonication fluid culture was 83.3%, of single positive tissue culture was 72.2% and 61.1% when two or more cultures yielded the same microorganism. In patients receiving antibiotic therapy the sensitivity was 65.9%, 57.5%, and 42.5%, respectively. Pathogens detected in a single tissue culture as well as in sonication culture yielded a significantly higher rate of prosthetic infection than conventional tissue culture alone (p = 0.008), even in patients receiving continuous antibiotic therapy before explantation (p = 0.016). The sonication method represents an essential add‐on in pathogen detection compared to conventional tissue culture. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:617–622, 2011
WRAPPA : A Screening Tool for Candidate Dehydron Identification

Solvent-exposed hydrogen bonds, or “dehydrons,” are becoming an increasingly important biochemical motif. The dehydron plays an important role in a wide variety of biological phenomena and has served as the basis for redesigning the anticancer agent imatinib to reduce its side effects. The rapid and reliable identification of dehydrons in proteins is thus becoming increasingly relevant to the community of life scientists at large. In this report we present a web-based program, called WRAPPA (www.wrappa.org), that allows biologists to incorporate dehydron analysis into their own research. WRAPPA is a tool for hypothesis generation and refinement: It locates hydrogen bonds in protein structures using simple geometric criteria and provides detailed molecular information about the local microenvironment of each bond, thereby identifying “candidate” dehydrons for experimental investigation.
The Effects of Reciprocal Teaching vs. Think-Aloud on Reading Comprehension of Pre- Intermediate Students in Iran

The purpose of this study was to investigate the ef fects of reciprocal teaching strategy and think-aloud strategy on the E nglish reading comprehension of Iranian students. Three pre-intermediate level clas ses were selected and randomly assigned into three groups: two experimental groups and one control group. One experimental group received think-aloud strategy, t he other one received reciprocal teaching strategy and the control group received a placebo. Reciprocal teaching involves four main reading strategies: predicting, questioning, clarifying and summarizing. Think-aloud involves prediction, formi ng mental pictures, connecting what they read to what they have already read, crea ting analogies, verbalizing confusing points, and using fix-up strategies. Ther e were pretest and posttest for these three groups. The findings indicated that the two experimental conditions of think-aloud strategy and reciprocal teaching strate gy had significantly positive effects on the reading comprehension of pre-interme diate EFL learners; however, think-aloud strategy enhanced English reading compr ehension better than reciprocal teaching strategy.
Is High Employee Turnover Really Harmful? An Empirical Test Using Company Records

We tested the hypothesis that employee turnover and firm performance have an inverted U-shaped relationship: overly high or low turnover is harmful. Our analysis was based on economic performance data from 110 offices of a temporary employment agency. These offices had high variation in turnover but were otherwise similar, allowing control for important intervening variables. Regression analysis revealed a curvilinear relationship; high turnover was harmful, but the inverted U-shape was not observed with certainty.