Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparative Study of Version Management Schemes for XML Documents

The problem of managing multiple versions for XML documents and semistructured data is of significant interest in many DB applications and web-related services. Traditional document version control schemes, such as RCS, suffer from the following two problems. At the logical level, they conceal the structure of the documents by modeling them as sequences of text lines, and storing a document’s evolution as a line-edit script. At the physical level, they can incur in severe storage or processing costs because of their inability to trade-off storage with computation. To solve these problems, we propose version management strategies that preserve the structure of the original document, and apply and extend DB techniques to minimize storage and processing costs. Therefore, we propose and compare three schemes for XML version management, namely, the Usefulness-Based Copy Control, the Multiversion B-Tree, and the Partially Persistent List Method. A common characteristic of these schemes is that they cluster data using the notion of page usefulness, which by selectively copying current information from obsolete pages provides for fast version reconstruction with minimal storage overhead. The cost and performance of these version management schemes are evaluated and compared through extensive analysis and experimentation.
Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes

In type 1 diabetes, diabetes-associated autoantibodies, including islet cell antibodies (ICAs), reflect adaptive immunity, while increased serum Nε-carboxymethyl-lysine (CML), an advanced glycation end product, is associated with proinflammation. We assessed whether serum CML and autoantibodies predicted type 1 diabetes and to what extent they were determined by genetic or environmental factors. Of 7,287 unselected schoolchildren screened, 115 were ICA+ and were tested for baseline CML and diabetes autoantibodies and followed (for median 7 years), whereas a random selection (n = 2,102) had CML tested. CML and diabetes autoantibodies were determined in a classic twin study of twin pairs discordant for type 1 diabetes (32 monozygotic, 32 dizygotic pairs). CML was determined by enzyme-linked immunosorbent assay, autoantibodies were determined by radioimmunoprecipitation, ICA was determined by indirect immunofluorescence, and HLA class II genotyping was determined by sequence-specific oligonucleotides. CML was increased in ICA+ and prediabetic schoolchildren and in diabetic and nondiabetic twins (all P < 0.001). Elevated levels of CML in ICA+ children were a persistent, independent predictor of diabetes progression, in addition to autoantibodies and HLA risk. In twins model fitting, familial environment explained 75% of CML variance, and nonshared environment explained all autoantibody variance. Serum CML, a glycotoxin, emerged as an environmentally determined diabetes risk factor, in addition to autoimmunity and HLA genetic risk, and a potential therapeutic target.
Sex and Age Differences in the Association of Blood Pressure and Hypertension with Cognitive Function in the Elderly: The Rancho Bernardo Study.

OBJECTIVES This study examines sex and age differences in associations of systolic and diastolic blood pressure (SBP, DBP), pulse pressure and hypertension with cognitive function in a community-dwelling population. DESIGN Cross-sectional study. SETTING Research clinic visit in 1988-91. PARTICIPANTS Participants were 693 men and 1022 women aged 50-97 Measurements: Blood pressure was measured and 12 cognitive function tests were administered. RESULTS Average age was 73.8±9.9 in men and 73.2±9.3 in women; 62.6% of men and 63.4% of women were hypertensive (SBP≥140 mmHg, DBP≥90 mmHg, or antihypertensive medication use). Each 5-unit increment in SBP, DBP, or pulse pressure and categorical hypertension was associated with significantly increased odds of poor verbal fluency performance in men and poor Trails B performance in women, with strongest associations for hypertension (OR=1.97, CI:1.01,3.85 in men; OR=1.51, CI:1.01,2.26 in women). After age stratification, associations remained statistically significant in younger (<80 years ) but not older (≥80 years) participants. CONCLUSION Blood pressure as a continuous or categorical variable was associated with poor performance on cognitive function tests, but domains varied by sex and associations were found only in those younger than 80 years. The absent associations in those aged 80 years and older could support the hypothesis that increased blood flow is required to maintain cerebral perfusion with advancing age, or could reflect a survivor effect.
Pseudomonas fluorescens WCS374r-Induced Systemic Resistance in Rice against Magnaporthe oryzae Is Based on Pseudobactin-Mediated Priming for a Salicylic Acid-Repressible Multifaceted Defense Response1[C][OA]

Selected strains of nonpathogenic rhizobacteria can reduce disease in foliar tissues through the induction of a defense state known as induced systemic resistance (ISR). Compared with the large body of information on ISR in dicotyledonous plants, little is known about the mechanisms underlying rhizobacteria-induced resistance in cereal crops. Here, we demonstrate the ability of Pseudomonas fluorescens WCS374r to trigger ISR in rice (Oryza sativa) against the leaf blast pathogen Magnaporthe oryzae. Using salicylic acid (SA)-nonaccumulating NahG rice, an ethylene-insensitive OsEIN2 antisense line, and the jasmonate-deficient mutant hebiba, we show that this WCS374r-induced resistance is regulated by an SA-independent but jasmonic acid/ethylene-modulated signal transduction pathway. Bacterial mutant analysis uncovered a pseudobactin-type siderophore as the crucial determinant responsible for ISR elicitation. Root application of WCS374r-derived pseudobactin (Psb374) primed naive leaves for accelerated expression of a pronounced multifaceted defense response, consisting of rapid recruitment of phenolic compounds at sites of pathogen entry, concerted expression of a diverse set of structural defenses, and a timely hyperinduction of hydrogen peroxide formation putatively driving cell wall fortification. Exogenous SA application alleviated this Psb374-modulated defense priming, while Psb374 pretreatment antagonized infection-induced transcription of SA-responsive PR genes, suggesting that the Psb374- and SA-modulated signaling pathways are mutually antagonistic. Interestingly, in sharp contrast to WCS374r-mediated ISR, chemical induction of blast resistance by the SA analog benzothiadiazole was independent of jasmonic acid/ethylene signaling and involved the potentiation of SA-responsive gene expression. Together, these results offer novel insights into the signaling circuitry governing induced resistance against M. oryzae and suggest that rice is endowed with multiple blast-effective resistance pathways.
Assessment of internet usage amongst Nigerian students — A case study approach

This study focused on the level of penetration of Internet usage among undergraduate students in Nigeria using Obafemi Awolowo University as a case study. Result showed that about 92% of undergraduate students have embraced the Internet and are using it consistently. The online mean time is 3.5 hrs/week while on the average, undergraduate experience of Internet usage is about 4 years. We found also that the students use the Internet mostly for e-mail, information search and online chatting; all of these were found to have significant impact on their academics and social life. Further analysis revealed that gender attitude is also an important issue; male students appear to use the Internet more than their female counterparts; just as science based students use it more than the non-science based students. The paper therefore recommends appropriate policies for all higher schools of learning in Nigeria to facilitate further diffusion and use of the Internet.
Uncoupled Matching for Active and Passive Impedances of Coupled Arrays in MIMO Systems

Impedance matching for coupled antenna arrays has received considerable attention in the research community. Because optimal matching requires implementation of a coupled network, leading to high complexity and often narrow operation bandwidth, new research has focused on the development of uncoupled matching networks with good performance. This paper explores traditional uncoupled impedance matching techniques for coupled arrays, specifically matching to the array active and passive impedances, within the context of multiple-input multiple-output communication. The concept of matching to the array active impedance is extended to the case where the propagating field is specified stochastically, and the performance of this solution is compared to that of traditional solutions using simulations. While emphasis is placed on matching for maximum power transfer, the paper concludes with a discussion on matching for minimum amplifier noise figure.
Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics

Understanding the basis for differential responses to drug therapies remains a challenge despite advances in genetics and genomics. Induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to investigate the pharmacology of disease processes in therapeutically and genetically relevant primary cell types in vitro and to interweave clinical and basic molecular data. We report here the derivation of iPSCs from a long QT syndrome patient with complex genetics. The proband was found to have a de novo SCN5A LQT-3 mutation (F1473C) and a polymorphism (K897T) in KCNH2, the gene for LQT-2. Analysis of the biophysics and molecular pharmacology of ion channels expressed in cardiomyocytes (CMs) differentiated from these iPSCs (iPSC-CMs) demonstrates a primary LQT-3 (Na+ channel) defect responsible for the arrhythmias not influenced by the KCNH2 polymorphism. The F1473C mutation occurs in the channel inactivation gate and enhances late Na+ channel current (INaL) that is carried by channels that fail to inactivate completely and conduct increased inward current during prolonged depolarization, resulting in delayed repolarization, a prolonged QT interval, and increased risk of fatal arrhythmia. We find a very pronounced rate dependence of INaL such that increasing the pacing rate markedly reduces INaL and, in addition, increases its inhibition by the Na+ channel blocker mexiletine. These rate-dependent properties and drug interactions, unique to the proband’s iPSC-CMs, correlate with improved management of arrhythmias in the patient and provide support for this approach in developing patient-specific clinical regimens.
Defining Vasospasm After Subarachnoid Hemorrhage: What Is the Most Clinically Relevant Definition?

Background and Purpose— Vasospasm is an important complication of subarachnoid hemorrhage, but is variably defined in the literature. Methods— We studied 580 patients with subarachnoid hemorrhage and identified those with: (1) symptomatic vasospasm, defined as clinical deterioration deemed secondary to vasospasm after other causes were eliminated; (2) delayed cerebral ischemia (DCI), defined as symptomatic vasospasm, or infarction on CT attributable to vasospasm; (3) angiographic spasm, as seen on digital subtraction angiography; and (4) transcranial Doppler (TCD) spasm, defined as any mean flow velocity >120 cm/sec. Logistic regression analysis was performed to test the association of each definition of vasospasm with various hospital complications, and 3-month quality of life (sickness impact profile), cognitive status (telephone interview of cognitive status), instrumental activities of daily living (Lawton score), and death or severe disability at 3 months (modified Rankin scale score 4–6), after adjustment for covariates. Results— Symptomatic vasospasm occurred in 16%, DCI in 21%, angiographic vasospasm in 31%, and TCD spasm in 45% of patients. DCI was statistically associated with more hospital complications (N=7; all P<0.05) than symptomatic spasm (N=4), angiographic spasm (N=1), or TCD vasospasm (N=1). Angiographic and TCD vasospasm were not related to any aspect of clinical outcome. Both symptomatic vasospasm and DCI were related to reduced instrumental activities of daily living, cognitive impairment, and poor quality of life (all P<0.05). However, only DCI was associated with death or severe disability at 3 months (adjusted OR, 2.2; 95% CI, 1.2–3.9; P=0.007). Conclusions— DCI is a more clinically meaningful definition than either symptomatic deterioration alone or the presence of arterial spasm by angiography or TCD.
The Protective Effect of Roadside Barriers for Motorcyclists

Objective: Roadside barriers are often deployed between road users and fixed hazards to protect users from injury. However, the United States and Australian Roadside Design Guides do not consider motorcyclists in the risk-based decision process for the deployment of a barrier, because the severity indices for barriers and fixed hazards were developed for passenger vehicles. The aim of the present article is to quantify the protective effect of barriers with regards to motorcyclist injury and to thereby inform the Roadside Design Guides as to the relative severity of roadside hazards and infrastructure for motorcyclists. Method: A retrospective case series study, using linked police-reported road crash and hospital admission data in New South Wales, Australia, from 2001 to 2009 was performed. Crude and adjusted relative risks of motorcyclist serious injury were determined for various fixed objects compared to barriers, using serious injury rates and multiple variable logistic regression. Calculated relative risks compared with guardrail for motorcyclists were compared with those determined from the United States and Australian Roadside Design Guides for passenger vehicle occupants. Results: The study identified 1364 motorcyclists injured as a result of single-vehicle collisions with roadside barriers, trees, utility poles, and other fixed roadside infrastructure. Trees, posts, and utility poles were shown to provide significantly higher risks of serious injury to motorcyclists compared to barriers. This was also found to be true for serious injuries to particular body regions, such as the head, spine, and torso. The results for motorcyclists were in reasonable agreement with those derived from severity indices in the United States and Australian Roadside Design Guides for passenger vehicle occupants. Conclusions: Roadside barriers provide a significant reduction in the risk of serious injury to motorcyclists compared to various roadside hazards. The provisions in the United States and Australian Roadside Design Guides for passenger vehicle occupants are generally applicable to motorcyclists and support the prior and ongoing use of such guides for designing roadsides that reduce the risk of injury to motorcyclists. However, a more realistic estimation might be derived by increasing the severity indices for barriers by around 25 percent for motorcyclists.
Speech recognition modeling advances for mobile voice search

This paper reports on the development and advances in automatic speech recognition for the AT&T Speak4it® voice-search application. With Speak4it as real-life example, we show the effectiveness of acoustic model (AM) and language model (LM) estimation (adaptation and training) on relatively small amounts of application field-data. We then introduce algorithmic improvements concerning the use of sentence length in LM, of non-contextual features in AM decision-trees, and of the Teager energy in the acoustic front-end. The combination of these algorithms, integrated into the AT&T Watson recognizer, yields substantial accuracy improvements. LM and AM estimation on field-data samples increases the word accuracy from 66.4% to 77.1%, a relative word error reduction of 32%. The algorithmic improvements increase the accuracy to 79.7%, an additional 11.3% relative error reduction.
Families of nations and public policy

Employing cluster analysis, this article reconsiders a concept formulated by Francis G. Castles that stresses the existence of four families of nations, which markedly differ in respect of public policy‐making. For two policy fields — social and economic policy — the hypothesised families of nations can be shown to exist, and they are quite robust and stable over time. Cluster analysis also reveals different paths towards modernity. On the one hand, there are more state‐oriented versus more market‐oriented models of public policy‐making; on the other, there is a cleavage in public policy‐making between rich countries located at the centre and somewhat poorer countries located at the periphery.
Opposing Role of NMDA Receptor GluN2B and GluN2D in Somatosensory Development and Maturation

Development of correct topographical connections between peripheral receptors and central somatosensory stations requires activity-dependent synapse refinement, in which the NMDA type of glutamate receptors plays a key role. Here we compared functional roles of GluN2B (GluRε2 or NR2B) and GluN2D (GluRε4 or NR2D), two major regulatory subunits of neonatal NMDA receptors, in development of whisker-related patterning at trigeminal relay stations. Compared with control littermates, both the appearance of whisker-related patterning and the termination of the critical period, as assessed by unilateral infraorbital nerve transection, were delayed by nearly a day in the somatosensory cortex of GluN2B+/− mice but advanced by nearly a day in GluN2D−/− mice. Similar temporal shifts were found at subcortical relay stations in the thalamus and brainstem of GluN2B+/− and GluN2D−/− mice. In comparison, the magnitude of lesion-induced critical period plasticity in the somatosensory cortex, as assessed following row-C whisker removal, was normal in both mutants. Thus, GluN2B and GluN2D play counteractive roles in temporal development and maturation of somatosensory maps without affecting the magnitude of critical period plasticity. To understand the opposing action, we then examined neuronal and synaptic expressions of the two subunits along the trigeminal pathway. At each trigeminal station, GluN2B was predominant at asymmetrical synapses of non-GABAergic neurons, whereas GluN2D was selective to asymmetrical synapses of GABAergic neurons. Together, our findings suggest that GluN2B expressed at glutamatergic synapses on glutamatergic projection neurons facilitates refinement of ascending pathway synapses directly, whereas GluN2D expressed at glutamatergic synapses on GABAergic interneurons delays it indirectly.
On the macroeconomic causes of exchange rates volatility

What are the causes of exchange rate volatility? When second moments implications of theories of exchange rates determination are considered, long-term fundamental linkages between macroeconomic and exchange rate volatility can be envisaged. Moreover, as the exchange rate is an important determinant of aggregate demand, bidirectional causality should be expected. The results of the paper support the above intuitions pointing to important linkages and trade-offs relating exchange rate and macroeconomic volatility, with causality direction stronger from macroeconomic volatility to exchange rate volatility than the other way around. In particular, with a long-term perspective, Friedman (1953) conclusions on the macroeconomic sources of exchange rates instability and the impossibility of eliminating systemic volatility find full support in the empirical findings.
The Open Agent Architecture: A Framework for Building Distributed Software Systems

The Open Agent Architecture (OAA), developed and used for several years at SRI International, makes it possible for software services to be provided through the cooperative efforts of distributed collections of autonomous agents. Communication and cooperation between agents are brokered by one or more facilitators, which are responsible for matching requests, from users and agents, with descriptions of the capabilities of other agents. Thus it is not generally required that a user or agent know the identities, locations, or number of other agents involved in satisfying a request. OAA is structured so as to minimize the effort involved in creating new agents and "wrapping" legacy applications, written in various languages and operating on various platforms; to encourage the reuse of existing agents; and to allow for dynamism and flexibility in the makeup ofagent communities. Distinguishing features of OAA as compared with related work include extreme flexibility in using facilitator-based delegation of com.
Henon mappings in the complex domain II: projective and inductive limits of polynomials

Let H: C^2 -> C^2 be the Henon mapping given by (x,y) --> (p(x) - ay,x). The key invariant subsets are K_+/-, the sets of points with bounded forward images, J_+/- = the boundary of K_+/-, J = the union of J_+ and J_-, and K = the union of K_+ and K_-. In this paper we identify the topological structure of these sets when p is hyperbolic and |a| is sufficiently small, ie, when H is a small perturbation of the polynomial p. The description involves projective and inductive limits of objects defined in terms of p alone.
Sloan School of Management Working Paper 4379-02 August 2002 How Do Large Depreciations Affect Firm Performance ?

This paper examines how 12 “major depreciations” between 1997 and 2000 affected different measures of firm performance in a sample of over 13,500 companies from around the world. Results suggest that in the year after depreciations, firms have significantly higher growth in market capitalization, but significantly lower growth in net income (when measured in local currency). Firms with a higher share of foreign sales exposure have significantly better performance after depreciations, according to a range of indicators. Firms with higher debt ratios tend to have lower net income growth, but there is no robust relationship between debt exposure and the other performance variables. Larger firms frequently have worse performance than smaller firms, although the significance and robustness of this result fluctuates across specifications. Kristin J. Forbes MIT Sloan School Room E52-455 50 Memorial Drive Cambridge, MA 02142 and NBER Tel: 617-253-8996 Fax: 617-258-6855 kjforbes@mit.edu http://web.mit.edu/kjforbes/www
Understanding help-seeking amongst university students: the role of group identity, stigma, and exposure to suicide and help-seeking

Background: Despite a high prevalence of suicide ideation and mental health issues amongst university students, the stigma of help-seeking remains a barrier to those who are in real need of professional support. Social identity theory states that help received from an ingroup source is more welcome and less threatening to one's identity than that from a source perceived as outgroup. Therefore, we hypothesized that students' stigma toward seeking help from their university mental health service would differ based on the strength of their identification with the university. Method: An online survey including measures of stigma of suicide, group identification, experience with help-seeking and exposure to suicide was administered to Irish university students (N = 493). Results: Group identification was a significant predictor of help-seeking attitudes after controlling for already known predictors. Contrary to our expectations, those who identified more strongly with their university demonstrated a higher stigma of seeking help from their university mental health service. Conclusions: Results are discussed in relation to self-categorization theory and the concept of normative fit. Practical implications for mental health service provision in universities are also addressed, specifically the need for a range of different mental health services both on and off-campus.