Miracle-dz/UniFAR-FTUs huggingface dataset:
Knowledge, attitude and practices of generic names usage in prescription among the medical postgraduate residents of a tertiary care teaching hospital: an observational cross-sectional study

Background: Establishment of Pradhan Mantri Bhartiya Janaushadhi Kendras through Pradhan Mantri Janaushadhi Pariyojana (PMBJP) is a breakthrough step to reduce expenses in healthcare due to costly branded names in prescription. Medical council of India also amended clause 1.5 of the Indian Medical Council Regulations, 2002 mandating the doctors to prescribe medicines by generic names in place of brand names. Moreover, medical practitioner nowadays has raised concern about education/qualification of the chemist who is being made the decision maker.Methods: In this questionnaire based cross-sectional observational study, all students admitted to post graduation course in academic year 2018 were included and those who were not willing to give consent were excluded from study. A knowledge, attitude and practices (KAP) questionnaire containing 12 questions was assessed by using true/false type and Likert scale-based questions. Descriptive statistics used to generate frequencies, percentages and proportions.Results: Majority of the population have answered positively about knowledge questions. Surprisingly 72.41% population don’t know about process of new drug approval. Most of them agreed to pros and cons of generic drug prescribing. 58.14% population always write generic names in their prescription. Shockingly 74.42% population write prescription based on their knowledge from promotional literature by a medical representative.Conclusions: Findings of present study highlights usefulness of the practice of writing generic names in prescriptions. It also raises concern about professional qualification of the chemist who will be decision maker in drug delivery to consumers.
From Random Process to Chaotic Behavior in Swarms of UAVs

Unmanned Aerial Vehicles (UAVs) applications have seen an important increase in the last decade for both military and civilian applications ranging from fire and high seas rescue to military surveillance and target detection. While this technology is now mature for a single UAV, new methods are needed to operate UAVs in swarms, also referred to as fleets. This work focuses on the mobility management of one single autonomous swarm of UAVs which mission is to cover a given area in order to collect information. Several constraints are applied to the swarm to solve this problem due to the military context. First, the UAVs mobility must be as unpredictable as possible to prevent any UAV tracking. However the Ground Control Station (GCS) operator(s) still needs to be able to forecast the UAVs paths. Finally, the UAVs are autonomous in order to guarantee the mission continuity in a hostile environment and the method must be distributed to ensure fault-tolerance of the system. To solve this problem, we introduce the Chaotic Ant Colony Optimization to Coverage (CACOC) algorithm that combines an Ant Colony Optimization approach (ACO) with a chaotic dynamical system. CACOC permits to obtain a deterministic but unpredictable system. Its performance is compared to other state-of-the art models from the literature using several coverage-related metrics, i.e. coverage rate, recent coverage and fairness. Numerical results obtained by simulation underline the performance of our CACOC method: a deterministic method with unpredictable UAV trajectories that still ensures a high area coverage.
A multilateral synthetic aperture wireless positioning approach to precise 3D localization of a robot tool center point

In this paper, a novel multilateral synthetic aperture secondary radar concept and its application for precise 3D localization of a robot tool center point (TCP) are introduced. A backscatter transponder is attached to the TCP of a robot. Spatially distributed FMCW secondary radar units pick up the backscattered phase coherent transponder signals. Based on assisting relative sensors, a synthetic aperture is created with the TCP. The developed multilateral inverse synthetic aperture reconstruction algorithm then determines a probability density function (PDF) of the spatial transponder position. By simulations and experimental results using a 5.8 GHz system with 140 MHz bandwidth it is shown, that 3D localization precision in the mm range can be achieved with the novel wireless local positioning concept even with narrowband radar systems in dense multipath environments. Heretofore, accuracies of this magnitude were only attainable with ultrawideband (UWB) systems utilizing a ten times wider bandwidth. It is shown, that the multilateral synthetic aperture locating system has the potential for a quantum leap in precise 3D wireless local positioning.
Initial Characterization of Alkaline Protease from Pseudomonas sp Isolated from Chicken Feces (POSTER)

Abstract Proteases are ubiquitous enzymes and it can be found in all living organisms. Extracellular proteases have high economic value, where the enzymes can be applied to various industrial sectors. In order to find an alternative source of protease, a search for microbe producing extracellular protease has been done using a selective medium. An extracellular producing bacterium that is identified as Pseudomonas sp has been isolated from chicken feces, that is Gallus gallus bankiva, collected from residential areas at Lowokwaru, Malang, Indonesia. The analysis shows that the bacterium produces extracellular protease with optimum activity after incubation of 66 hours at 35oC. Initial characterization of the extracellular protease shows that the extracellular protease produced by Pseudomonas sp has an optimum activity at pH 12 and an optimum temperature at 39oC. At these conditions, the crude extract enzyme has a specific activity of 0,522 U/mg. The high pH resistance allows its application to variety of industrial processes that require high pH operation. Therefore further studies need to be done to get better understanding of enzyme properties. Keywords: Alkaline protease, Chicken feces, Gallus gallus bankiva, Pseudomonas sp
Decomposing the Effect of Workload on Patient Outcomes : An Empirical Analysis of a Maternity Unit

Extant literature provides strong evidence that service quality (e.g., patient outcomes) deteriorates at high levels of workload. In this paper, we use a detailed dataset from the delivery unit of a major teaching hospital to better understand how workload impacts quality. We consider two mechanisms: direct impact through deterioration in the quality of task execution and indirect through the choice of care pathway. First, we demonstrate that workload has an effect on the care pathway – discretionary but resource-intensive interventions, such as pain relief, are less likely to be administered at high workloads. Second, we show that workload increases the propensity of some adverse outcomes, such as perineal tears, and reduces others, such as emergency cesarean sections. The effect on perineal tears is predominantly direct, while the effect on cesarean sections is indirect. We also examine post-birth length of stay and find that the direct and indirect effects work in opposite directions; while both effects are individually significant, they cancel each other out on aggregate. Our results provide a better understanding of how workload affects quality in service settings and we demonstrate how they can be used to predict changes in outcomes and costs under different demand and staffing scenarios.
Analysis and Design of an Integrated Notch Filter for the Rejection of Interference in UWB Systems

A 0.13-mu m CMOS fourth-order notch filter for the rejection of the 5-6 GHz interference in UWB front-ends is reported. The filter is integrated into an analog front-end for Mode #1 UWB. A thorough analysis based on a simplified model of the filter is carried out. An algorithm for the automatic tuning and calibration of the filter is also discussed and demonstrated. Two versions of the circuit are designed and fabricated: the first comprises a low-noise amplifier and the filter, and the second expands it to a complete front-end. In the latter version the filter was also redesigned. The filter provides more than 35 dB of attenuation and has a tuning range of 900 MHz, adding less than 30% power consumption to the LNA. The out-of-band IIP3 (higher than -13.2 dBm with the filter off) takes a 9-dB advantage from the filter and the compression of the gain due to the out-of-band blocker is reduced by at least 6 dB in the complete front-end. The conversion gain of the front-end is 25 dB per channel, its average noise figure is lower than 6.2 dB, and its in-band 1-dB compression point is higher than - 30 dBm at a power consumption of 32 mW.
Exploring the Relationship Between Ethical Awareness and Personality Traits of Undergraduate Engineering Students

This study explores the relationship between ethical awareness and personality traits of undergraduate engineering students. Data analysis is presented of survey results collected at a large, public Midwestern R1 University investigating this relationship. Students’ ethical awareness was measured through the use of five of Lockheed Martin’s Challenge Game ethical vignettes. Personality traits were determined using Digman’s Big Five Personality (BFP) test. Other measures included Graziano’s Person and Thing Orientations (PTO) and Paulhus & Van Seals’s Spheres of Control (SOC). We hypothesized that students who were identified as having “agreeable”, “extroverted”, and “conscientious” personality (based on the BFP test) are more inclined to be ethically aware than those who were identified as “open to experience” or “neurotic”. Results showed that those who spoke English as a first language and those who had lived outside of their home country for more than 6 months were more likely to provide “ethically aware” answers to the vignettes. Contrary to our hypothesis, multiple regression analysis showed that personality traits did not explain the variance observed in differences on ethical awareness as measured by the survey scales. Future work will include continued survey validation analysis, as well as cluster analysis to see if there are particular personality profiles that are indicative of ethical awareness.
Effect of dietary selenium yeast supplementation on physico-chemical characteristics of goat meat.

The current study assessed the influence of selenium yeast (SeY) on some physico-chemical characteristics of goat meat. A total of ten cross- bred goats of 4 months age and 10.5 kg body weight were assigned into two groups, viz. Control and SeY (n=5 each group) and provided only basal diet (control) or basal diet supplemented with SeY at the dose of 0.3 mg/kg feed. The experiment lasted for eight weeks. The results revealed that physical characteristics of meat were not different (P> 0.05) between the groups; however, the meat pH decreased by 0.15 units and the cooking and drip losses were reduced by approximately 11 and 13.5 % in SeY goats as compared to control. The determination of chemical characteristics showed no significant changes (P> 0.05) in the moisture, protein and ash contents, however, the fat content of meat tended to increase (P< 0.097) by 37.5% in SeY compared to that in control. In conclusion, the results of present study showed that most of the physico-chemical properties of meat were not significantly different between the two groups except for fat content which tended to increase in SeY goats compared to control. The increase in fat content was associated with slight decrease in some physical characteristics such as pH, water holding capacity and cooking loss of meat in SeY goats, which suggest that SeY supplementation in the diet of goats slightly improved physico-chemical properties of meat.
Mercure: Towards an Automatic E-mail Follow-up System

This paper discusses the design and the approach we have developed in order to deal effectively with customer e- mails sent to a corporation. We first present the current state of the art and then make the point that natural language tools are needed in order to deal effectively with the rather informal style encountered in the e-mails. In our project, called Mercure, we have explored three complementary approaches: classification, case-based reasoning and question-answering.
The Discontinuous Nature of Propagation in Normal Canine Cardiac Muscle: Evidence for Recurrent Discontinuities of Intracellular Resistance that Affect the Membrane Currents

When the propagation velocity of action potentials is modified by changing the internal resistance of a cell, cable theory predicts that the shape of the action potential upstroke should not change; changes in velocity associated with changes in the upstroke usually are attributed to changes in membrane properties. However, we observed, in normal cardiac muscle, that changes in the upstroke with velocity occur under conditions in which the membrane properties could not have changed. Propagation in atrial and ventricular muscle was studied, in which the velocity of propagation was different at different angles with respect to the cell orientation. Fast upstrokes were associated with low propagation velocities (in a direction transverse to the long cell axis) and slower upstrokes were associated with high propagation velocities (in the direction of the long cell axis). Such changes in the shape of depolarization can be accounted for by the discrete cellular nature of cardiac muscle. The recurrent discontinuities in intracellular resistance cause propagation to be discontinuous on a microscopic scale. The presence of discontinuities in intracellular resistance reverses the usual association of high velocity and high safety factor for propagation: propagation at a low velocity is actually more resistant to disturbances in membrane properties than is propagation at a higher velocity. This inverted relationship suggested that propagation could continue in a direction transverse to the long axis of the cells when block occurs in the longitudinal direction, with resultant reentrant propagation. Such prediction was confirmed in the study of the propagation of premature action potentials in atrial muscle. Circ Res 48: 39-54, 1981
Interaction between transcription factors Iroquois proteins 4 and 5 controls cardiac potassium channel Kv4.2 gene transcription.

AIMS The homeobox transcription factor, Iroquois protein 5 (Irx5), plays an essential role in the generation of region-selective expression of Kv4.2 gene across the left ventricular wall of rodent hearts. Here, we analyse molecular mechanisms underlying the Irx5-induced regulation of the rat Kv4.2 promoter. METHODS AND RESULTS The mRNA levels for Irx members in various heart regions were assessed by RT-PCR. A luciferase reporter gene with the rat Kv4.2 promoter was used to test the effects of Irx members on channel promoter activity. Irx3 and Irx5 mRNAs were differentially distributed across the left ventricular wall, whereas Irx4 message was equally abundant in various ventricular regions. Irx5, but not Irx3 or Irx4, increased Kv4.2 promoter activity in 10T1/2 fibroblasts, whereas the transcription factor decreased promoter activity in neonatal ventricular myocytes. These effects were mediated by the C-terminal portion of Irx5. Irx4 appeared to inhibit the Irx5-induced increase in channel promoter activity in 10T1/2 cells. The N-terminal region of Irx4 was necessary and sufficient for this inhibition. Furthermore, when endogenous Irx4 expression was suppressed with siRNA, Irx5 increased channel promoter activity in neonatal myocytes. CONCLUSION These results indicate that Irx5 possesses the ability to activate the Kv4.2 promoter. The abundant Irx4 expression throughout the rat ventricle may play a role in the inverse relationship between Irx5 and Kv4.2 levels across the left ventricular wall.
Probabilistic end-to-end delay bounds for earliest deadline first scheduling

We analyze the earliest-deadline-first (EDF) scheduling discipline within the framework of statistical multiplexing. We derive techniques for bounding the probability of delay violations when the session injections are independent. This enables us to determine whether a given set of sessions can all meet their delay bounds with the required violation probability. These techniques can be used by a connection admission control (CAC) scheme to decide whether to admit a new session. Our analysis applies to both the single node problem and the network problem in which the sessions have multiple hops. We also give extensive numerical results to illustrate how our bounds may be calculated and to compare the results with estimates that have been derived for generalized processor sharing (GPS). In addition we show that by altering the deadlines for EDF we can match the desired violation probabilities more closely.
Variation of pH in lysed platelet concentrates influence proliferation and alkaline phosphatase activity in human osteoblast-like cells

Activated platelets release a multifaceted blend of growth factors that has stimulatory effects on mesenchymal cells, both in vitro and in vivo, which imply beneficial effects on wound repair and tissue regeneration. Previous studies on fibroblast cultures have revealed that more potent growth factors, with respect to cell proliferation, are released in acidic preparations of lysed platelet concentrates in comparison with neutral and alkaline preparations. The current study was intended to investigate the influence of pH on lysed platelet concentrates with respect to release of growth factors, cell proliferation and alkaline phosphatase (ALP) activity in human osteoblast-like cells (hFOB 1.19). Cell proliferation was assessed with the MTT kit, ALP activity by conventional enzymatic reaction kinetics and growth factors platelet-derived growth factor (PDGF) and transforming growth factor-β (TGF-β) by enzyme-linked immunosorbent assays. Osteoblast-like cells were stimulated with lysed platelet concentrates preincubated at pH 4.4, 5.4, 7.4, and 7.6. A 3–13-fold increase of cell proliferation was found in comparison with controls and the most evident increase was observed with platelets activated at pH 5.4. The highest ALP activity was observed in preparations at pH 7.6. Platelets incubated in an acidic environment (pH 5.4) induced a higher proliferation compared with preincubation at neutral or alkaline pH and the level of PDGF was also found to be higher in acidic preincubations. The level of TGF-β was, in contrast, lowest at pH 4.4. We suggest, based on these experimental findings, that acidic milieu influence platelets to release growth factors more potent to stimulate osteoblast proliferation than neutral and alkaline platelet preparations. Lysed platelet concentrates prepared at an alkaline pH might release additional components with stimulating effects resulting in other features than cell proliferation. This is the first report, to our knowledge, about a pH dependent stimulatory effect of lysed platelet concentrates on human osteoblast-like cell proliferation. Lysed platelet concentrates, preincubated in acidic or alkaline buffers, may benefit fracture healing, implant fixation and might also be advantageous in the treatment of wounds with platelet constituents; however, this has to be investigated in extended experimental and clinical settings.
Wading through the Muddy Waters of Recovered Memory

The author reviews the professional debate about recovered memories of childhood sexual abuse and addresses conceptual errors, unwarranted assumptions, and factual inaccuracies in Benatar's essay “Running Away from Sexual Abuse: Denial Revisited” in the May 1995 Families in Society. Despite the fact that many therapists believe that repression or dissociation is a common response to childhood sexual abuse, little support for this idea is found in scientific studies. The author reviews the recent literature in this area and cautions social workers to avoid getting caught in the extreme polemics of this debate. Although it is important to be open to new findings in this area, we must be able to distinguish between conjecture and fact.
Testing a developmental cascade model of emotional and social competence and early peer acceptance

Abstract A developmental cascade model of early emotional and social competence predicting later peer acceptance was examined in a community sample of 440 children across the ages of 2 to 7. Children's externalizing behavior, emotion regulation, social skills within the classroom and peer acceptance were examined utilizing a multitrait–multimethod approach. A series of longitudinal cross-lag models that controlled for shared rater variance were fit using structural equation modeling. Results indicated there was considerable stability in children's externalizing behavior problems and classroom social skills over time. Contrary to expectations, there were no reciprocal influences between externalizing behavior problems and emotion regulation, although higher levels of emotion regulation were associated with decreases in subsequent levels of externalizing behaviors. Finally, children's early social skills also predicted later peer acceptance. Results underscore the complex associations among emotional and social functioning across early childhood.
Moving Toward Neo-Totalitarianism: A Political-Sociological Analysis of the Evolution of Administrative Absorption of Society in China

Abstract China recently promulgated and revised a number of laws, regulations and measures to regulate the nonprofit sector. All these administrative efforts increase support for Chinese nonprofit organizations (NPOs) on the one hand and put unprecedented pressure on them on the other. The seemingly contradictory effects are actually based on the same logic of Administrative Absorption of Society (AAS). This article proposes three phases in the development of AAS: an subconscious phase, a theory-modeling phase, and an institutionalization phase. The institutionalization of AAS has led to the rise of neo-totalitarianism, which is featured by state capitalism, unlimited government, and a mixed ideology of Marxism and Confucianism. Neo-totalitarianism further strengthens AAS and has begun to reshape the relationship between the state and the nonprofit sector. This article analyzes China’s nonprofit policymaking from a sociopolitical perspective, and clarifies the context, the characteristics, and the evolution of laws and policies in the nonprofit sector in macrocosm.
ITR : Understanding Stress Resistance Mechanisms in Plants : Multimodal Models Integrating Experimental Data , Databases , and the Literature

Next Generation Software: A Microarray Experiment Management System. Co-PIs: N. Ramakrishnan, R. G. Alscher, L. S. Heath, L.T. Watson, J. Weller EIA-0103660, $600,000, 09/01/2001–08/31/2004. This project supports the design and implementation of Expresso a system for microarray experiment management. The NSF NGS program specifically calls for innovative software designs for emerging applications. In this regard, Expresso provides novel algorithms (i) for model-based design and management of microarray experiments, (ii) for integrating experiment design and data analysis to ‘close the loop,’ and (iii) for supporting a lightweight data management system. The specific computational capabilities of Expresso are discussed at several places in this proposal, especially as they pertain to results from our microarray experiments and the choice of data analysis techniques.