Miracle-dz/UniFAR-FTUs huggingface dataset:
Discussing the Undiscussable: A Guide to Overcoming Defensive Routines in the Workplace

Foreword by Chris Argyris. Acknowledgments. About the Author. PART ONE: DEFINING DEFENSIVE ROUTINES. 1. Framing the Issue: The Work of Chris Argyris. 2. The Foundational Skill Set. PART TWO: MARK, BRENDA, YOU, AND ME: BRINGING DEFENSIVE ROUTINES ABOUT AND KEEPING THEM IN PLACE. 3. Conditions of Threat and Embarrassment: Fix It Now or Fix It Later, Scene One: The Bad News. 4. Being in Control: Fix It Now or Fix It Later, Scene Two: The Word Gets Out. 5. Bypass Tactics and Covering Up: Fix It Now or Fix It Later, Scene Three: Being Nice. PART THREE: DISCUSSING THE UNDISCUSSABLE. 6. Strategic Interventions: Interviews and Mapping. 7. The De-Escalation: Fix It Now or Fix It Later: Mark and Brenda Reflect. 8. Engaging Differences. 9. Key Thought Enablers. PART FOUR: STAYING ON THE PATH OF LEARNING. 10. Mistakes, Continuous Learning, and Progress. 11. Helping Those Who Teach, Learn. Conclusion. Appendix A: Mapping Templates. Appendix B: Strategies for Case Study Groups. Bibliography. Index. How to Use the DVD.
Chromosome Transfer Induced Aneuploidy Results in Complex Dysregulation of the Cellular Transcriptome in Immortalized and Cancer Cells

Chromosomal aneuploidies are observed in essentially all sporadic carcinomas. These aneuploidies result in tumor-specific patterns of genomic imbalances that are acquired early during tumorigenesis, continuously selected for and faithfully maintained in cancer cells. Although the paradigm of translocation induced oncogene activation in hematologic malignancies is firmly established, it is not known how genomic imbalances affect chromosome-specific gene expression patterns in particular and how chromosomal aneuploidy dysregulates the genetic equilibrium of cells in general. To model specific chromosomal aneuploidies in cancer cells and dissect the immediate consequences of genomic imbalances on the transcriptome, we generated artificial trisomies in a karyotypically stable diploid yet mismatch repair-deficient, colorectal cancer cell line and in telomerase immortalized, cytogenetically normal human breast epithelial cells using microcell-mediated chromosome transfer. The global consequences on gene expression levels were analyzed using cDNA arrays. Our results show that regardless of chromosome or cell type, chromosomal trisomies result in a significant increase in the average transcriptional activity of the trisomic chromosome. This increase affects the expression of numerous genes on other chromosomes as well. We therefore postulate that the genomic imbalances observed in cancer cells exert their effect through a complex pattern of transcriptional dysregulation.
Reinforcement social learning of social optimality with influencer agents

In many multiagent systems (MAS), it is desirable that the agents can coordinate with one another on achieving socially optimal outcomes to increase the system level performance, and the traditional way of attaining this goal is to endow the agents with social rationality (in: Proc. of AAAI Fall Symposium on Socially Intelligent Agents, 1997, pp. 61-63) - agents act as system utility maximizers. However, this is difficult to implement when we are facing open MAS domains such as peer-to-peer network and mobile ad-hoc networks, since we do not have control on all agents' behaviors in such systems and each agent usually behaves individually rationally as an individual utility maximizer only. In this paper, we propose injecting a number of influencer agents (in: Proc. of AAMAS'13, ACM Press, 2013, pp. 447-454, AAMAS (2012)) to manipulate the behaviors of individually rational agents and investigate whether the individually rational agents can eventually be incentivized to coordinate on achieving socially optimal outcomes. We evaluate the effects of influencer agents in two common types of games: prisoner's dilemma games and anti-coordination games. Simulation results show that a small proportion of influencer agents can significantly increase the average percentage of socially optimal outcomes attained in the system and better performance can be achieved compared with that of previous work.
Rhinotillexomania: psychiatric disorder or habit?

BACKGROUND Conditions once considered bad habits are now recognized as psychiatric disorders (trichotillomania, onychopagia). We hypothesized that nose picking is another such "habit," a common benign practice in most adults but a time-consuming, socially compromising, or physically harmful condition (rhinotillexomania) in some. METHODS We developed the Rhinotillexomania Questionnaire, mailed it to 1000 randomly selected adult residents of Dane County, Wisconsin, and requested anonymous responses. The returned questionnaires were analyzed according to age, sex, marital status, living arrangement, and educational level. Nose picking was characterized according to time involved, level of distress, location, attitudes toward self and others regarding the practice, technique, methods of disposal, reasons, complications, and associated habits and psychiatric disorders. RESULTS Two hundred fifty-four subjects responded. Ninety-one percent were current nose pickers although only 75% felt "almost everyone does it"; 1.2% picked at least every hour. For 2 subjects (0.8%), nose picking caused moderate to marked interferences with daily functioning. Two subjects spent between 15 and 30 minutes and 1 over 2 hours a day picking their nose. For 2 others, perforation of the nasal septum was a complication. Associated "habits" included picking cuticles (25%), picking at skin (20%), biting fingernails (18%), and pulling out hair (6%). CONCLUSION This first population survey of nose picking suggests that it is an almost universal practice in adults but one that should not be considered pathologic for most. For some, however, the condition may meet criteria for a disorder-rhinotillexomania.
The Optic Nerve Head in Congenital Fibrosis of the Extraocular Muscles

Objective: Optic nerve head abnormalities have been reported in some patients with congenital fibrosis of the extraocular muscles (CFEOM). This study prospectively assesses optic nerve head appearance in a consecutive CFEOM cohort. Methods: All patients with CFEOM referred between 2006 and 2010 and who were mature enough to cooperate with fundus photography were included. Fundus photographs were reviewed with attention to optic nerve head features (eg, cupping >0.6, asymmetric cupping >0.3, optic nerve hypoplasia). Interested participants had CFEOM candidate gene analysis (KIF21A, TUBB3, PHOX2A) for genetic counseling purposes. Results: Ten CFEOM patients (five CFEOM1, five CFEOM3, age range 5–23 years) from eight families (all consanguineous but one) participated. All 10 patients had notable disc excavation (5) or optic nerve hypoplasia (5). CFEOM candidate gene analysis was performed in all patients and revealed a heterozygous p.R954W KIF21A mutation only in the patient who was not from a consanguineous family. Conclusions: Our observations suggest the optic nerve head can be affected by the orbital dysinnervation that occurs in CFEOM. Because careful clinical optic nerve head assessment is difficult in young patients with CFEOM and associated large angle incomitant strabismus, optic nerve head abnormalities may be under-diagnosed. The absence of mutations in known CFEOM genes in our cohort of consanguineous families suggests further genetic heterogeneity of this group of conditions.
Study of the Variations of Archaeological Marks at Neolithic Site of Lucera, Italy Using High-Resolution Multispectral Datasets

Satellite images have been systematically explored by archaeologists to detect crop marks, which are considered as a proxy for the identification of buried archaeological remains. Even though several existing algorithms are frequently applied, such as histogram enhancements and vegetation indices, the detection of crop marks still remains a difficult task, while the final interpretation results can be very poor. This paper aims to present some of the current difficulties of “remote sensing archaeology” in terms of detection and interpretation of crop marks due to the crops’ phenological variations. At the same time, the presented work seeks to evaluate the recently proposed linear equations for the enhancement of crop marks, initially developed for the eastern Mediterranean region. These linear equations re-project the initial n-space spectral into a new 3D orthogonal space determined by three components: a crop mark component, a vegetation component, and a soil component. For the aims of this study, the Lucera archaeological site (southern Italy), where several Neolithic trenches have been identified, was selected. QuickBird and GeoEye high-resolution satellite images were analysed, indicating that vegetation indices may mismatch some crop marks depending on the phenological stage of the vegetation cultivated in the area of the archaeological site. On the contrary, ratios from linear equations were able to spot these crop marks even in shadow areas, indicating that improvements and developments of novel methodologies and equations based on remote sensing datasets can further assist archaeological research.
Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human

Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated by strikingly different and unique reproductive strategies and central regulatory mechanisms that can be present in even closely related animal species. In all mammals studied so far, type-I gonadotropin releasing hormone (GnRH) synthesizing neurons form the final common output way from the hypothalamus in the neuroendocrine control of the adenohypophysis. Under various physiological and pathological conditions, hormonal and metabolic signals either regulate GnRH neurons directly or act on upstream neuronal circuitries to influence the pattern of pulsatile GnRH secretion into the hypophysial portal circulation. Neuronal afferents to GnRH cells convey important metabolic-, stress-, sex steroid-, lactational-, and circadian signals to the reproductive axis, among other effects. This article gives an overview of the available neuroanatomical literature that described the afferent regulation of human GnRH neurons by peptidergic, monoaminergic, and amino acidergic neuronal systems. Recent studies of human genetics provided evidence that central peptidergic signaling by kisspeptins and neurokinin B (NKB) play particularly important roles in puberty onset and later, in the sex steroid-dependent feedback regulation of GnRH neurons. This review article places special emphasis on the topographic distribution, sexual dimorphism, aging-dependent neuroanatomical changes, and plastic connectivity to GnRH neurons of the critically important human hypothalamic kisspeptin and NKB systems.
Aversion to side effects in preventive medical treatment decisions.

OBJECTIVES Individuals may be overly sensitive to the side effects of treatments aimed at preventing illness, in part because they have difficulty in evaluating situations with several possible outcomes that differ in probability. This study tested willingness to undergo a hypothetical preventive treatment and accuracy in determining the probability of harm from the treatment as a function of the presence of a side effect, the initial probability of harm, the format in which probabilities were presented (percentages or frequencies), and the presence or absence of a graphic. DESIGN The study was a factorial experiment involving 5,251 participants. METHODS Participants recruited from a health-oriented internet site read about a hypothetical cancer prevention treatment situation and were asked to indicate their willingness to accept this treatment and whether it would increase or decrease their overall risk of cancer. The net benefit of the treatment was the same in all conditions, whether or not it was associated with a small side effect. RESULTS The presence of information about a side effect dramatically decreased willingness to undergo preventive treatment and accuracy in evaluating the treatment's effects. Willingness and accuracy were not influenced by the initial probability of harm, whether the risk probability information was presented as frequencies (N in 100) or as percentages, or whether the initial risk was presented with a bar graph or an array of asterisks or stick figures. CONCLUSIONS Individuals are highly averse to preventive treatments with even small side effects and have difficulty combining the likelihood of positive and negative outcomes to determine the treatment's overall benefits.
Secondary Teachers' Perceived Role in Suicide Prevention and Intervening with Suicidal Students

Secondary Teachers’ Perceived Role in Suicide Prevention and Intervening with Suicidal Students Victoria Hatton Department of Counseling Psychology and Special Education, BYU Educational Specialist Best practices in adolescent suicide prevention include teachers as major participants, because teachers are in a unique and frontline position to support students. Unfortunately, many teachers are unaware of their role in suicide prevention efforts. In addition to confusion about their roles, teachers may feel uncomfortable and/or lack confidence in their abilities to identify warning signs and intervene with suicidal students. This study assessed secondary teachers’ (N = 74) perceptions of their role in suicide prevention as well as how they perceive their comfort and confidence levels in identifying and intervening with suicidal students. In addition, this study explored possible reasons teachers might feel uncomfortable assisting in suicide prevention. While teachers overwhelmingly agreed that they should have a role in adolescent suicide prevention, teachers also reported having limited confidence in their ability to identify or help potentially suicidal youth. Teachers also acknowledged limited training, fear of making the situation worse, and fear of legal repercussions as potential barriers to participating in suicide prevention efforts. Consequently, teachers will benefit from more direct training which clearly identifies their roles and allows opportunities for teachers to role play.
Airborne Asbestos Levels in School Buildings in Italy

This article provides a summary of environmental investigations carried out from 1992 to 2002 by the National Institute for Occupational Prevention and Safety on airborne asbestos fiber concentrations in Italian schools. The monitoring was performed to evaluate the risk from asbestos exposure to students and school staff. Fifty-nine schools located in several Italian regions were studied. A detailed visual examination assisted with locating asbestos-containing materials in different school areas. Asbestos was mainly present in the vinyl floor coverings and in the asbestos-cement products (roofs, facades, and heating ducts). After the identification of the potential sources of exposure, several bulk and air samplings were performed in the areas where the contamination was suspected. All air samplings were collected on membrane filters and analyzed by phase contrast optical microscopy and scanning electron microscopy. During the course of the samplings, the schools were in operation and normal student activities took place. Most of the results provided no significant evidence of airborne asbestos fibers, although some dispersion was found in a few school buildings where, during the past years, monitoring and safety programs had not been implemented.
The Effects of Air Pollution on Hospitalizations for Cardiovascular Disease in Elderly People in Australian and New Zealand Cities

Objective The goal of this study was to estimate the associations between outdoor air pollution and cardiovascular hospital admissions for the elderly Design Associations were assessed using the case–crossover method for seven cities: Auckland and Christchurch, New Zealand; and Brisbane, Canberra, Melbourne, Perth, and Sydney Australia. Results were combined across cities using a random-effects meta-analysis and stratified for two adult age groups: 15–64 years and ≥ 65 years of age (elderly). Pollutants considered were nitrogen dioxide, carbon monoxide, daily measures of particulate matter (PM) and ozone. Where multiple pollutant associations were found, a matched case–control analysis was used to identify the most consistent association. Results In the elderly, all pollutants except O3 were significantly associated with five categories of cardiovascular disease admissions. No associations were found for arrhythmia and stroke. For a 0.9-ppm increase in CO, there were significant increases in elderly hospital admissions for total cardiovascular disease (2.2%), all cardiac disease (2.8%), cardiac failure (6.0%), ischemic heart disease (2.3%), and myocardial infarction (2.9%). There was some heterogeneity between cities, possibly due to differences in humidity and the percentage of elderly people. In matched analyses, CO had the most consistent association. Conclusions The results suggest that air pollution arising from common emission sources for CO, NO2, and PM (e.g., motor vehicle exhausts) has significant associations with adult cardiovascular hospital admissions, especially in the elderly, at air pollution concentrations below normal health guidelines. Relevance to clinical and professional practice Elderly populations in Australia need to be protected from air pollution arising from outdoor sources to reduce cardiovascular disease.
Protective Effect of Lycium ruthenicum Murr. Against Radiation Injury in Mice

The protective effect of Lycium ruthenicum Murr. against radiation injury was examined in mice. Kunming mice were randomly divided into a control group, model group, positive drug group and L. ruthenicum high dose (8 g/kg), L. ruthenicum middle dose (4 g/kg), L. ruthenicum low dose (2 g/kg) treatment groups, for which doses were administered the third day, seventh day and 14th day after irradiation. L. ruthenicum extract was administered orally to the mice in the three treatment groups and normal saline was administered orally to the mice in the control group and model group for 14 days. The positive group was treated with amifostine (WR-2721) at 30 min before irradiation. Except for the control group, the groups of mice received a 5 Gy quantity of X-radiation evenly over their whole body at one time. Body weight, hemogram, thymus and spleen index, DNA, caspase-3, caspase-6, and P53 contents were observed at the third day, seventh day, and 14th day after irradiation. L. ruthenicum could significantly increase the total red blood cell count, hemoglobin count and DNA contents (p < 0.05). The spleen index recovered significantly by the third day and 14th day after irradiation (p < 0.05). L. ruthenicum low dose group showed a significant reduction in caspase-3 and caspase-6 of serum in mice at the third day, seventh day, and 14th day after irradiation and L. ruthenicum middle dose group experienced a reduction in caspase-6 of serum in mice by the seventh day after irradiation. L. ruthenicum could decrease the expression of P53. The results showed that L. ruthenicum had protective effects against radiation injury in mice.
PENGARUH MOTIVASI KERJA DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN (Studi pada Karyawan Bagian Produksi PT. Karmand Mitra Andalan Surabaya)

This study aimed to explain the influence of the partial work motivation on employee performance, to explain the influence of the partial work environment on employee performance and to explain work motivation and work environment on employee performance simultaneously. Based on the results of the analysis indicate that the work motivation is significantly influence the performance of the employees of PT. Mitra Andalan Karmand Surabaya, indicated by the t significant value of 0.000 smaller than a = 0.05 (0.000 l0.05) with the regression coefficient of 0.636. Work environment has a significant effect on the performance of employees of PT. Mitra Andalan Karmand Surabaya, indicated by the t significant value of 0,013 less than a = 0.05 (0.013 l0.05) with the regression coefficient of 0.226. Work motivation and the work environment is simultaneously significant effecting the performance of employees in PT. Mitra Andalan Karmand Surabaya, indicated by F significant value of 0.000 smaller than a = 0.05 (0.000 l0.05) and were able to contribute to the performance variables of 0.660 or 66%. The remaining 34% is influenced by other variables that are not examined in this study.
Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair

To date, three main gasotransmitters, that is, hydrogen sulfide (H2S), carbon monoxide (CO), and nitric oxide (NO), have been discovered to play major bodily physiological roles. These gasotransmitters have multiple functional roles in the body including physiologic and pathologic functions with respect to the cellular or tissue quantities of these gases. Gasotransmitters were originally known to have only detrimental and noxious effects in the body but that notion has much changed with years; vast studies demonstrated that these gasotransmitters are precisely involved in the normal physiological functioning of the body. From neuromodulation, oxidative stress subjugation, and cardiovascular tone regulation to immunomodulation, these gases perform critical roles, which, should they deviate from the norm, can trigger the genesis of a number of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). The purpose of this review is to discuss at great length physical and chemical properties and physiological actions of H2S, NO, and CO as well as shedding light on recently researched molecular targets. We particularly put emphasis on the roles in neuronal inflammation and neurodegeneration and neuronal repair.
Nonlinear Difference-in-Differences in Repeated Cross Sections with Continuous Treatments

This paper studies the identification of nonseparable models with continuous, endogenous regressors, also called treatments, using repeated cross sections. We show that several treatment effect parameters are identified under two assumptions on the effect of time, namely a weak stationarity condition on the distribution of unobservables, and time variation in the distribution of endogenous regressors. Other treatment effect parameters are set identified under curvature conditions, but without any function form restrictions. This result is related to the difference-in-differences idea, but imposes neither additive time effects nor exogenously defined control groups. Furthermore, we investigate two extrapolation strategies that allow us to point identify the entire model: using monotonicity of the error term, or imposing a linear correlated random coefficient structure. Finally, we illustrate our results by studying the effect of mother's age on infants' birth weight.
Validation of INNWIND.EU Scaled Model Tests of a Semisubmersible Floating Wind Turbine

The subject of this study is the verification and the validation of existing numerical codes for floating offshore wind turbine structures using wave tank model tests as part of the INNWIND.EU project. A model of the OC4-DeepCwind semisubmersible platform, together with a Froude-scaled rotor model, is tested in a combined wind-and-wave basin. The simulation environment comprises a multibody approach with hydrodynamic and aerodynamic loads and mooring line forces. The focus of this paper is the validation of the hydrodynamics of a modified model hull shape, which compensates for the excess mass of the nacelle. The results show that the simulation model agrees well with the experiment.