Miracle-dz/UniFAR-FTUs huggingface dataset:
Structural complexes in the squid giant axon membrane sensitive to ionic concentrations and cardiac glycosides

Giant nerve fibers of squid Sepioteuthis sepiodea were incubated for 10 min in artificial sea water (ASW) under control conditions, in the absence of various ions, and in the presence of cardiac glycosides. The nerve fibers were fixed in OsO(4) and embedded in Epon, and structural complexes along the axolemma were studied. These complexes consist of a portion of axolemma exhibiting a three-layered substructure, an undercoating of a dense material (approximately 0.1μm in length and approximately 70-170 A in thickness), and a narrowing to disappearance of the axon-Schwann cell interspace. In the controls, the incidence of complexes per 1,000μm of axon perimeter was about 137. This number decreased to 10-25 percent when magnesium was not present in the incubating media, whatever the calcium concentration (88, 44, or 0 mM). In the presence of magnesium, the number and structural features of the complexes were preserved, though the number decreased to 65 percent when high calcium was simultaneously present. The complexes were also modified and decreased to 26-32 percent by incubating the nerves in solutions having low concentrations of sodium and potassium. The adding of 10(-5) M ouabain or strophanthoside to normal ASW incubating solution decreased them to 20-40 percent. Due to their sensitivity to changes in external ionic concentrations and to the presence of cardiac glycosides, the complexes are proposed to represent the structural correlate of specialized sites for active ion transport, although other factors may be involved.
Alpha 2 Delta (α2δ) Ligands, Gabapentin and Pregabalin: What is the Evidence for Potential Use of These Ligands in Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a complex disorder that is characterized by abdominal pain and altered bowel habit, and often associates with other gastrointestinal symptoms such as feelings of incomplete bowel movement and abdominal bloating, and extra-intestinal symptoms such as headache, dyspareunia, heartburn, muscle pain, and back pain. It also frequently coexists with conditions that may also involve central sensitization processes, such as fibromyalgia, irritable bladder disorder, and chronic cough. This review examines the evidence to date on gabapentin and pregabalin which may support further and continued research and development of the α2δ ligands in disorders characterized by visceral hypersensitivity, such as IBS. The distribution of the α2δ subunit of the voltage-gated calcium channel, possible mechanisms of action, pre-clinical data which supports an effect on motor–sensory mechanisms and clinical evidence that points to potential benefits in patients with IBS will be discussed.
Sickle cell diseases and ileus.

BACKGROUND We tried to understand whether or not there is an increased incidence of ileus in patients with sickle cell diseases (SCDs). METHODS All cases with SCDs were taken into the study. RESULTS The study included 325 patients (160 females). The mean ages were similar in both sexes (29.3 versus 29.8 years in females and males, respectively, p > 0.05). Incidence of ileus was higher in males, significantly (3.6% versus 1.2%, p < 0.01). All of the ileus cases were able to be treated with simple and repeated red blood cell (RBC) transfusions without any surgical procedure. Smoking was higher in males, too (21.8% versus 6.2%, p < 0.001). The mean hematocrit value was also higher in males, significantly (24.4% versus 23.0%, p = 0.016). RBC units transfused, digital clubbing, leg ulcers, pulmonary hypertension, chronic obstructive pulmonary disease, coronary heart disease, and chronic renal disease were all higher in males, too (p < 0.05 for all). On the other hand, although the general mortality, white blood cell and platelet counts of peripheric blood, painful crises per year, rheumatic heart disease, avascular necrosis of bone, cirrhosis, and stroke were all higher in males, the differences were nonsignificant probably due to the small sample sizes of the groups (p > 0.05 for all). CONCLUSION Although the relatively young mean ages of the patients with SCDs, the very high incidences of ileus are probably due to the strong atherosclerotic and obstructive natures of the two pathologies, and ileus should be treated with simple and repeated RBC transfusions to restore bowel perfusion in such patients.
Mechanisms of antidepressant resistance

Depression is one of the most frequent and severe mental disorder. Since the discovery of antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds, several classes of psychotropic drugs have shown be effective in treating major depressive disorder (MDD). However, there is a wide range of variability in response to ADs that might lead to non response or partial response or in increased rate of relapse or recurrence. The mechanisms of response to AD therapy are poorly understood, and few biomarkers are available than can predict response to pharmacotherapy. Here, we will first review markers that can be used to predict response to pharmacotherapy, such as markers of drug metabolism or blood-brain barrier (BBB) function, the activity of specific brain areas or neurotransmitter systems, hormonal dysregulations or plasticity, and related molecular targets. We will describe both clinical and preclinical studies and describe factors that might affect the expression of these markers, including environmental or genetic factors and comorbidities. This information will permit us to suggest practical recommendations and innovative treatment strategies to improve therapeutic outcomes.
Dspp-independent Effects of Transgenic Trps1 Overexpression on Dentin Formation

The Trps1 transcription factor is highly expressed in dental mesenchyme and preodontoblasts, while in mature, secretory odontoblasts, it is expressed at low levels. Previously, we have shown that high Trps1 levels in mature odontoblasts impair their function in vitro and in vivo. Col1a1-Trps1 transgenic (Trps1-Tg) mice demonstrate defective dentin secretion and mineralization, which are associated with significantly decreased Dspp expression due to direct repression of the Dspp gene by Trps1. Here, by crossing Trps1-Tg and Col1a1-Dspp transgenic (Dspp-Tg) mice, we generated Col1a1-Trps1;Col1a1-Dspp double transgenic (double-Tg) mice in which Dspp was restored in odontoblasts overexpressing Trps1. Comparative micro–computed tomography analyses revealed partial correction of the dentin volume and no improvement of dentin mineralization in double transgenic mice in comparison with Trps1-Tg and wild-type (WT) mice. In addition, dentin of double-Tg mice has an irregular mineralization pattern characteristic for dentin in hypophosphatemic rickets. Consistent with this phenotype, decreased levels of Phex, Vdr, and Fam20c proteins are detected in both Trps1-Tg and double-Tg odontoblasts in comparison with WT and Dspp-Tg odontoblasts. This suggests that the Dspp-independent dentin mineralization defects in Trps1-Tg mice are a result of downregulation of a group of proteins critical for mineral deposition within the dentin matrix. In summary, by demonstrating that Trps1 functions as a repressor of later stages of dentinogenesis, we provide functional significance of the dynamic Trps1 expression pattern during dentinogenesis.
Ultrasound evaluation of the impact of cricoid pressure versus novel ‘paralaryngeal pressure’ on anteroposterior oesophageal diameter

To assess the degree to which cricoid pressure (Sellick manoeuvre) actually compresses the oesophagus, we measured the effect of cricoid pressure and paralaryngeal pressure on the outer anteroposterior diameter of the upper oesophagus with ultrasound in 39 healthy volunteers. The mean (SD) outer anteroposterior oesophageal diameter was 0.77 (0.11) cm with no pressure, 0.79 (0.13) cm with the application of cricoid pressure of 30 N and 0.68 (0.12) cm with the application of paralaryngeal pressure of 30 N (p < 0.0001). If cricoid pressure does not reduce the anteroposterior diameter of the oesophagus, it is difficult or impossible to explain the efficacy of the Sellick manoeuvre. However, paralaryngeal pressure decreases this diameter and has the potential to occlude the upper oesophagus.
Genetic variation in bone morphogenetic protein and colon and rectal cancer

Bone morphogenetic proteins (BMP) are part of the TGF‐β‐signaling pathway; genetic variation in these genes may be involved in colorectal cancer. In this study, we evaluated the association between genetic variation in BMP1 (11 tagSNPs), BMP2 (5 tagSNPs), BMP4 (3 tagSNPs), BMPR1A (9 tagSNPs), BMPR1B (21 tagSNPs), BMPR2 (11 tagSNPs) and GDF10 (7 tagSNPs) with risk of colon and rectal cancer and tumor molecular phenotype. We used data from population‐based case‐control studies (colon cancer n = 1,574 cases, 1,970 controls; rectal cancer n = 791 cases, 999 controls). We observed that genetic variation in BMPR1A, BMPR1B, BMPR2, BMP2 and BMP4 was associated with risk of developing colon cancer, with 20 to 30% increased risk for most high‐risk genotypes. A summary of high‐risk genotypes showed over a twofold increase in colon cancer risk at the upper risk category (OR = 2.49 95% CI = 1.95, 3.18). BMPR2, BMPR1B, BMP2 and GDF10 were associated with rectal cancer. BMPR2 rs2228545 was associated with an almost twofold increased risk of rectal cancer. The risk associated with the highest category of the summary score for rectal cancer was 2.97 (95% CI = 1.87, 4.72). Genes in the BMP‐signaling pathway were consistently associated with CIMP+ status in combination with both KRAS‐mutated and MSI tumors. BMP genes interacted statistically significantly with other genes in the TGF‐β‐signaling pathway, including TGFβ1, TGFβR1, Smad 3, Smad 4 and Smad 7. Our data support a role for genetic variation in BMP‐related genes in the etiology of colon and rectal cancer. One possible mechanism is via the TGF‐β‐signaling pathway.
Prognostic Value of Real Time Myocardial Contrast Echocardiography after Percutaneous Coronary Intervention

Real time myocardial contrast echocardiography (RTMCE) is a cost‐effective and simple method to quantify coronary flow reserve (CFR). We aimed to determine the value of RTMCE to predict cardiac events after percutaneous coronary intervention (PCI). We have studied myocardial blood volume (A), velocity (β), flow indexes (MBF, A × β), and vasodilator reserve (stress‐to‐rest ratios) in 36 patients with acute coronary syndrome (ACS) who underwent PCI. CFR (MBF at stress/MBF at rest) was calculated for each patient. Perfusion scores were used for visual interpretation by MCE and correlation with TIMI flow grade. In qualitative RTMCE assessment, post‐PCI visual perfusion scores were higher than pre‐PCI (Z = −7.26, P < 0.01). Among 271 arteries with TIMI flow grade 3 post‐PCI, 72 (36%) did not reach visual perfusion score 1. The β‐ and A × β‐reserve of the abnormal segments supplied by obstructed arteries increased after PCI comparing to pre‐PCI values (P < 0.01). Patients with adverse cardiac events had significantly lower β‐ and lower A × β‐reserve than patients without adverse cardiac events. In the former group, the CFR was ≥ 1.5 both pre‐ and post‐PCI. CFR estimation by RTMCE can quantify myocardial perfusion in patients with ACS who underwent PCI. The parameters β‐reserve and CFR combined might predict cardiac events on the follow‐up.
Is Network Clustering Detectable in Transmission Trees?

Networks are often used to model the contact processes that allow pathogens to spread between hosts but it remains unclear which models best describe these networks. One question is whether clustering in networks, roughly defined as the propensity for triangles to form, affects the dynamics of disease spread. We perform a simulation study to see if there is a signal in epidemic transmission trees of clustering. We simulate susceptible-exposed-infectious-removed (SEIR) epidemics (with no re-infection) over networks with fixed degree sequences but different levels of clustering and compare trees from networks with the same degree sequence and different clustering levels. We find that the variation of such trees simulated on networks with different levels of clustering is barely greater than those simulated on networks with the same level of clustering, suggesting that clustering can not be detected in transmission data when re-infection does not occur.
Speech Performance and Sound Localization Abilities in Neurelec Digisonic® SP Binaural Cochlear Implant Users

In this prospective study the outcome of the Digisonic® SP Binaural cochlear implant (CI), a device enabling electric stimulation of both cochleae by a single receiver, was evaluated in 14 postlingually deafened adults after 12 months of use. Speech perception was tested using French disyllabic words in quiet and in speech-shaped noise at +10 dB signal-to-noise ratio. Horizontal sound localization in quiet was tested using pink noise coming from 5 loudspeakers, from –90 to +90° along the azimuth. Speech scores in quiet were 76% (±19.5 SD) in the bilateral condition, 62% (±24 SD) for the better ear alone and 43.5% (±27 SD) for the poorer ear alone. Speech scores in noise were 60% (±27.5 SD), 46% (±28 SD) and 28% (±25 SD), respectively, in the same conditions. Statistical analysis showed a significant advantage of the bilateral use in quiet and in noise (p < 0.05 compared to the better ear). Significant spatial perception benefits such as summation effect (p < 0.05), head shadow effect (p < 0.0001) and squelch effect (p < 0.0005) were noted. Sound localization accuracy improved significantly when using the device in the bilateral condition with an average root mean square of 35°. Compared with published outcomes of usual bilateral cochlear implantation, this device could be a valuable alternative to two CIs. Prospective controlled trials, comparing the Digisonic SP Binaural CI with a standard bilateral cochlear implantation are mandatory to evaluate their respective advantages and cost-effectiveness.
Racial differences in peripheral insulin sensitivity and mitochondrial capacity in the absence of obesity.

CONTEXT African-American women (AAW) have an increased risk of developing type 2 diabetes compared with Caucasian women (CW). Lower insulin sensitivity has been reported in AAW, but the reasons for this racial difference and the contributions of liver versus skeletal muscle are incompletely understood. OBJECTIVE We tested the hypothesis that young, nonobese AAW manifest lower insulin sensitivity specific to skeletal muscle, not liver, and is accompanied by lower skeletal muscle mitochondrial oxidative capacity. PARTICIPANTS AND MAIN OUTCOME MEASURES Twenty-two nonobese (body mass index 22.7 ± 3.1 kg/m(2)) AAW and 22 matched CW (body mass index 22.7 ± 3.1 kg/m(2)) underwent characterization of body composition, objectively assessed habitual physical activity, and insulin sensitivity with euglycemic clamps and stable-isotope tracers. Skeletal muscle biopsies were performed for lipid content, fiber typing, and mitochondrial measurements. RESULTS Peripheral insulin sensitivity was 26% lower in AAW (P < .01), but hepatic insulin sensitivity was similar between groups. Physical activity levels were similar between groups. Lower insulin sensitivity in AAW was not explained by total or central adiposity. Skeletal muscle triglyceride content was similar, but mitochondrial content was lower in AAW. Mitochondrial respiration was 24% lower in AAW and correlated with skeletal muscle insulin sensitivity (r = 0.33, P < .05). CONCLUSION When compared with CW, AAW have similar hepatic insulin sensitivity but a muscle phenotype characterized by both lower insulin sensitivity and lower mitochondrial oxidative capacity. These observations occur in the absence of obesity and are not explained by physical activity. The only factor associated with lower insulin sensitivity in AAW was mitochondrial oxidative capacity. Because exercise training improves both mitochondrial capacity and insulin sensitivity, we suggest that it may be of particular benefit as a strategy for diabetes prevention in AAW.
Electrical Stimulation of Vascular Autonomic Nerves: Effects on Heart Rate, Blood Pressure, and Arrhythmias

Recent clinical studies have shown conflicting results of the efficacy of renal sympathetic denervation (RSD) to mitigate hypertension. In this study, we compared electrical stimulation (ES) of autonomic nerves on the surface of the left pulmonary artery (LPA) and renal arteries (RAs) on heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP), and cardiac arrhythmias.
Hematopoietic stem-cell transplantation.

Hematopoietic stem-cell transplantation, which is used to treat both malignant and nonmalignant conditions, was first conceived more than 50 years ago, but problems associated with transplanting a nonsolid organ and modulating the immune response had to be solved before the procedure could be used clinically. This review summarizes background information about hematopoietic stem-cell transplantation and discusses the current role of the procedure.
Fair end-to-end window-based congestion control

In this paper, we demonstrate the existence of fair end-to- end window-based congestion control protocols for packet- switched networks with FCFS routers. Our definition of fairness generalizes proportional fairness and includes arbitrarily close approximations of max-min fairness. The protocols use only information that is available to end hosts and are designed to converge reasonably fast. Our study is based on a multiclass fluid model of the network. The convergence of the protocols is proved using a Lyapunov function. The technical challenge is in the construction of the protocols.
Improving Low-Resource Neural Machine Translation with Filtered Pseudo-Parallel Corpus

Large-scale parallel corpora are indispensable to train highly accurate machine translators. However, manually constructed large-scale parallel corpora are not freely available in many language pairs. In previous studies, training data have been expanded using a pseudo-parallel corpus obtained using machine translation of the monolingual corpus in the target language. However, in low-resource language pairs in which only low-accuracy machine translation systems can be used, translation quality is reduces when a pseudo-parallel corpus is used naively. To improve machine translation performance with low-resource language pairs, we propose a method to expand the training data effectively via filtering the pseudo-parallel corpus using a quality estimation based on back-translation. As a result of experiments with three language pairs using small, medium, and large parallel corpora, language pairs with fewer training data filtered out more sentence pairs and improved BLEU scores more significantly.
Optimization of distributed detection systems under the minimum average misclassification risk criterion

A common model for distributed detection systems is that of several separated sensors each of which measures some observable, quantizes it, and communicates to a fusion center the quantized observation. The fusion center collects the quantized observations and takes the decision. The article deals with the design of the quantizers and of the fusion center under a rate constraint. The system of interest allows soft nonbreakpoint quantizers and nonindependent observations. Our finding is that locally optimal design of the distributed detection system is feasible via alternate minimization of the average misclassification risk.
Analysis of self-noise in a clock recovery system with a high-order nonlinearity

This paper presents a new technique to compute efficiently the spectra of the in-phase (I) and quadrature (Q) components as well as the cross-spectrum of the in-phase and quadrature (I-Q) components of self-noise appearing at the output of the zero-memory, high-order nonlinear (NL) device employed in a clock recovery system. It is known that these spectra play an important role in the phase jitter performance of the clock regenerator. The results are very general and applicable to many cases of practical interest. Numerical examples and computer simulations provided show that the new approach yields very accurate results and is much faster than the usual computer simulation method. In addition, we give a theorem to show that for the signal shapes having linear phase, the cross-power spectrum of self-noise is zero. We also provide a general expression for the jitter variance of the generated clock signal in terms of the power spectra of self-noise in-phase and quadrature components. It is shown that the cross-power spectrum also contributes to timing jitter if the selected signaling shape does not have any symmetry in time domain. The optimal periodic sampling instants are determined by the axis crossings of the clock signal in the positive direction. The axis is set at a level whereby the jitter variance takes on a minimum value. It is concluded that when the cross-power spectrum is zero for all frequencies then the optimal sampling instants occur at the positive zero crossings of the clock signal and only the Q noise contributes to the timing jitter performance.
On the Wyner-Ziv problem for individual sequences

We consider a variation of the Wyner-Ziv (W-Z) problem pertaining to lossy compression of individual sequences using finite-state encoders and decoders. There are two main results in this paper. The first characterizes the relationship between the performance of the best M-state encoder-decoder pair to that of the best block code of size lscr for every input sequence, and shows that the loss of the latter relative to the former (in terms of both rate and distortion) never exceeds the order of (logM)/lscr, independently of the input sequence. Thus, in the limit of large M, the best rate-distortion performance of every infinite source sequence can be approached universally by a sequence of block codes (which are also implementable by finite-state machines). While this result assumes an asymptotic regime where the number of states is fixed, and only the length n of the input sequence grows without bound, we then consider the case where the number of states M=Mn is allowed to grow concurrently with n. Our second result is then about the critical growth rate of Mn such that the rate-distortion performance of Mn-state encoder-decoder pairs can still be matched by a universal code. We show that this critical growth rate of Mn is linear in n
Content-based Neighbor Models for Cold Start in Recommender Systems

Cold start remains a prominent problem in recommender systems. While rich content information is often available for both users and items few existing models can fully exploit it for personalization. Slow progress in this area can be partially attributed to the lack of publicly available benchmarks to validate and compare models. This year's ACM Recommender Systems Challenge' 17 aimed to address this gap by providing a standardized framework to benchmark cold start models. The challenge organizer XING released a large scaled data collection of user-job interactions from their career oriented social network. Unlike other competitions, here the participating teams were evaluated in two phases -- offline and online. Models were first evaluated on the held-out offline test set. Top models were then A/B tested in the online phase where new target users and items were released daily and recommendations were pushed into XING's live production system. In this paper we present our approach to this challenge, we used a combination of content and neighbor-based models winning both offline and online phases. Our model produced the most consistent online performance wining four of the five online weeks, and showed excellent generalization in the live A/B setting.