Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Age, Sex, Parity, Haemoglobin Level, and Oral Contraceptive Preparations on the Normal Leucocyte Count

In a study of the leucocyte counts of 408 male and 789 female blood donors aged 18–65, it was found that the male total leucocyte and differential counts did not vary significantly with age. In women the neutrophil and lymphocyte counts decreased significantly with increasing age, the fall in the neutrophils being pre‐dominantly a post‐menopausal occurrence, while the decrease in lymphocyte count was more evenly distributed and remained at a lower level than the male count throughout. In contrast, analysis confined to women not using oral contraceptives revealed a lower neutrophil count, and to a lesser extent lymphocyte count, in the youngest women. The increase in neutrophil count of women using the‘Pill’was independent of the length of time the‘Pill’had been taken. The reasons for the variations in leucocyte count with increasing age are discussed, with emphasis on the possible role of oestrogens in the control of the neutrophil count.
Clonogenic potential and phenotypic analysis of CD34+ cells mobilized by different chemotherapy regimens.

BACKGROUND AND OBJECTIVE Since limited data concerning quantitative and qualitative differences of CD34+ cells collected after different mobilization schedules are available, we investigated phenotype, proliferative capacity and primitive progenitor cell content of CD34+ cells mobilized with four different regimens. DESIGN AND METHODS The number, phenotype, and progenitor cell content of CD34+ cells were investigated in 46 patients mobilized with cyclophosphamide (CY) 7 g/m(2) plus granulocyte colony-stimulating factor (G-CSF, 5 microg/kg) (CY7+G-CSF) (n=16), CY 4 g/m(2) plus G-CSF (CY4+G-CSF) (n=8), IVE [ifosphamide (2.5 g/m(2) for 3 d), etoposide (150 mg/m(2) for 3 d), epirubicin (100 mg/m(2) on day 1)] plus G-CSF (IVE+G-CSF) (n=9), or G-CSF (10 microg/kg) alone (n=13). RESULTS The number of CD34+ cells collected per liter of processed blood was significantly higher in the CY7+G-CSF group than in the CY4+G-CSF and G-CSF groups (p </= .005), but not the IVE+G-CSF group. As compared to patients in the CY4+G-CSF group, those mobilized with CY7+G-CSF and IVE+G-CSF produced significantly lower percentages of CD34+ cells lacking CD38, CD33, CD45RA, and HLA-DR (p </= .016, at least). In addition, CY4+G-CSF mobilized CD34+ cells had a significantly higher plating efficiency than the cells mobilized in other ways (p </= r .036). In the G-CSF group, colony-forming cells and long-term culture-initiating cells were significantly lower than in the CY groups (p </= .0014 and </= 013, respectively). INTERPRETATION AND CONCLUSIONS Our data demonstrate that: (i) different mobilization regimens allow the collection of CD34+ cells with distinct phenotypic and proliferative features; (ii) evaluation of the absolute number of CD34+ cells by itself is not a reliable indicator of the clonogenic content of blood mobilized with different chemotherapy regimens; (iii) because of the substantial impact that chemotherapy regimens have on the quantity and quality of collected CD34+ cells, anticancer effects and optimal blood progenitor cell yields should be evaluated for each chemotherapy schedule.
A Multi-media Approach to Cross-lingual Entity Knowledge Transfer

When a large-scale incident or disaster occurs, there is often a great demand for rapidly developing a system to extract detailed and new information from low-resource languages (LLs). We propose a novel approach to discover comparable documents in high-resource languages (HLs), and project Entity Discovery and Linking results from HLs documents back to LLs. We leverage a wide variety of language-independent forms from multiple data modalities, including image processing (image-to-image retrieval, visual similarity and face recognition) and sound matching. We also propose novel meth-ods to learn entity priors from a large-scale HL corpus and knowledge base. Using Hausa and Chinese as the LLs and English as the HL, experiments show that our approach achieves 36.1% higher Hausa name tagging F-score over a costly supervised model, and 9.4% higher Chinese-to-English Entity Linking accuracy over state-of-the-art.
Impact of modulation frequency on cross-phase modulation effect in intensity modulation-direct detection WDM systems

The impact of modulation frequency on the crossphase modulation (XPM) effect in intensity modulation (IM)-direct detection wavelength-division multiplexing systems is investigated theoretically and numerically. A simple expression for IM is derived, verified by simulation and its validity is presented. The dependence of XPM-induced IM on the fiber length, fiber dispersion, channel separation and pump modulation frequency is assessed. It is shown that at very low frequency the walkoff effect has almost no influence on the XPM-induced IM efficiency which increases with the square of the frequency; at higher frequency the IM efficiency can be reduced significantly by the walkoff and scales linearly with modulation frequency.
Molecular mechanism : the pharmacodynamics and pharmacokinetics of abciximab

Antiplatelet therapy constitutes a cornerstone in the strategies aimed at the effective management of acute coronary syndrome. Abciximab is the oldest and most commonly used intravenous antiplatelet agent in this context, in particular when an invasive strategy is adopted. It is very commonly used in more unstable and high-risk patients. Trials have proven the event-free survival benefits of using abciximab in the right context. This agent also has some adverse outcomes associated with its use that the clinicians need to be well aware of and take precautions against. The comparative cost efficacy with its use too is of significance. There is a growing evidence base on the different ways abciximab is used and the benefits and risks thereof. Since the development and introduction of novel anticoagulants and more potent oral anti-platelet agents, the place of abciximab in the treatment of acute coronary syndrome today needs to be reviewed and clearly defined. This review attempts to study the cross-section of the evidence base to date on the clinical use, efficacy and risks related to the use of abciximab and spotlight the most recent guidelines published by the different global peak bodies to provide a practical overview to the clinician.
Biopolitics and Temporality in Arendt and Foucault

The article demonstrates that Hannah Arendt's examination of modern temporality strongly intersects with Michel Foucault's diagnosis of modern biopolitics. Both observe three key features of biopolitical modernity: the political zoefication of life, a technocratic understanding of politics, and processual temporality which link the project of modernity to the project of 20th-century totalitarianism. Arendt, however, also offers an alternative, nonbiopolitical understanding of politics, life, and time captured in the concept of natality. Built into the concept of natality is the ‘weakly’ messianic temporal structure of the interval as opposed to processual temporality.
Individualism–Collectivism and the Role of Goal Orientation in Organizational Training

This research examines how individualism–collectivism and goal orientation impact training effectiveness through study of an internationally diverse sample of engineers who were undergoing technical training. In light of contemporary views of individualism–collectivism, we argue that collectivism will moderate the influence of learning and performance goal orientations on training by shaping the impact of one's perceived social context on existing performance concerns and goals. Using a sample from a large multinational corporation, we examined the effects of individualism–collectivism and goal orientation on training transfer intentions, motivation to learn, and test performance. Mixed support for our hypotheses was found. Collectivists were found to exhibit higher levels of training transfer intentions and motivation to learn. However, when collectivism was combined with a performance goal orientation, its effects on training outcomes were diminished. Applications for organizations and future extensions of the present research are discussed.
Heading for disaster: Fusarium graminearum on cereal crops.

UNLABELLED SUMMARY The rapid global re-emergence of Fusarium head blight disease of wheat and barley in the last decade along with contamination of grains with mycotoxins attributable to the disease have spurred basic research on the fungal causal agent. As a result, Fusarium graminearum quickly has become one of the most intensively studied fungal plant pathogens. This review briefly summarizes current knowledge on the pathogenicity, population genetics, evolution and genomics of Fusarium graminearum. TAXONOMY Based on the sexual state Gibberella zeae (Schwein.) Petch: Superkingdom Eukaryota; Kingdom Fungi; Phylum Ascomycota; Subphylum Pezizomycotina; Class Sordariomycetidae; Subclass Hypocreomycetidae; Order Hypocreales; Family Nectriaceae; Genus Gibberella. HOST RANGE The pathogen is capable of causing head blight or 'scab' on wheat (Triticum), barley (Hordeum), rice (Oryza), oats (Avena) and Gibberella stalk and ear rot disease on maize (Zea). The fungus also may infect other plant species without causing disease symptoms. Other host genera cited for Gibberella zeae or F. graminearum sensu lato (see below) are Agropyron, Agrostis, Bromus, Calamagrostis, Cenchrus, Cortaderia, Cucumis, Echinochloa, Glycine, Hierochloe, Lolium, Lycopersicon, Medicago, Phleum, Poa, Schizachyrium, Secale, Setaria, Sorghum, Spartina and Trifolium. Disease symptoms and signs: For wheat, brown, dark purple to black necrotic lesions form on the exterior surface of the florets and glume (Fig. 1). Although these lesion symptoms sometimes are referred to as scab, they are not formally related to the hyperplasia and hypertrophic epidermal growth associated with other scab diseases such as apple scab. Peduncles immediately below the inflorescence may become discoloured brown/purple. With time, tissue of the inflorescence often becomes blighted, appearing bleached and tan, while the grain within atrophies. Awns often become deformed, twisted and curved downward. In barley, infections are not always readily apparent in the field. Infected spikelets may show a browning or water-soaked appearance. Infected barley kernels show a tan to dark brown discolouration that can be similar to that caused by other kernel blighting organisms. During prolonged wet periods, pink to salmon-orange spore masses of the fungus are often seen on infected spikelets, glumes and kernels in both wheat and barley. For maize ear rot, infection occurs by way of colonizing silk and thus symptoms first appear at the ear apex. White mycelium, turning pink to red with time, colonizes kernels and may progress basipetally, covering the entire ear. USEFUL WEBSITES http://www.broad. mit.edu/annotation/fungi/fusarium/mips.gsf. de/genre/proj/fusarium/ http://www.cdl. umn.edu/scab/gz-consort.html http://www.scabusa. org/
Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function

The homeostasis of the hematopoietic stem/progenitor cell pool relies on a fine-tuned balance between self-renewal, differentiation and proliferation. Recent studies have proposed that mitochondria regulate these processes. Although recent work has contributed to understanding the role of mitochondria during stem cell differentiation, it remains unclear whether the mitochondrial content/function affects human hematopoietic stem versus progenitor function. We found that mitochondrial mass correlates strongly with mitochondrial membrane potential in CD34+ hematopoietic stem/progenitor cells. We, therefore, sorted cord blood CD34+ cells on the basis of their mitochondrial mass and analyzed the in vitro homeostasis and clonogenic potential as well as the in vivo repopulating potential of CD34+ cells with high (CD34+ MitoHigh) versus low (CD34+ MitoLow) mitochondrial mass. The CD34+ MitoLow fraction contained 6-fold more CD34+CD38− primitive cells and was enriched in hematopoietic stem cell function, as demonstrated by its significantly greater hematopoietic reconstitution potential in immuno-deficient mice. In contrast, the CD34+ MitoHigh fraction was more enriched in hematopoietic progenitor function with higher in vitro clonogenic capacity. In vitro differentiation of CD34+ MitoLow cells was significantly delayed as compared to that of CD34+ MitoHigh cells. The eventual complete differentiation of CD34+ MitoLow cells, which coincided with a robust expansion of the CD34− differentiated progeny, was accompanied by mitochondrial adaptation, as shown by significant increases in ATP production and expression of the mitochondrial genes ND1 and COX2. In conclusion, cord blood CD34+ cells with low levels of mitochondrial mass are enriched in hematopoietic repopulating stem cell function whereas high levels of mitochondrial mass identify hematopoietic progenitors. A mitochondrial response underlies hematopoietic stem/progenitor cell differentiation and proliferation of lineage-committed CD34− cells.
Infective endocarditis at a tertiary care centre in Lebanon: predominance of streptococcal infection.

OBJECTIVES Infective endocarditis (IE) remains a disease associated with high morbidity and mortality. Many epidemiological studies have been reported worldwide; however, data from the Middle East is scarce. Most studies have recently shown a trend towards increasing incidence of Staphylococcus aureus endocarditis and decreasing prevalence of rheumatic heart disease as a predisposing condition. METHODS We conducted a retrospective review of all recorded cases of IE in adult patients admitted between 1986 and 2001 to the American University of Beirut-Medical Centre. RESULTS The total number of cases was 91. The mean age was 48 years. Fifty-nine percent of patients had a predisposing cardiac condition, rheumatic heart disease being the most common (33%). Blood cultures were positive in 77.5% of the cases: the most commonly isolated organisms were Streptococcus spp. (51%; of which 57% were viridans streptococci.) and Staphylococcus spp. (36%; of which 72% were S. aureus and 28% were coagulase-negative staphylococci). Transoesophageal echocardiography was performed in 36 patients (40%), of which 32 (89%) showed positive findings. When applying the revised Duke criteria, 82% of the patients were classified as definite and 16.5% as possible endocarditis. Surgery was performed in 32% of cases mostly for valvular regurgitation, followed by heart failure. The complication rate was 69% with congestive heart failure, drug-related toxicities, new valvular regurgitation and systemic embolisation being the most common. The in-hospital mortality rate was 18%. CONCLUSIONS Unlike data reported from the United States and northern Europe, this study confirms that in Lebanon, a developing country, we continue to have a predominance of streptococci as aetiologic agents in IE, and rheumatic heart disease as the most common underlying heart condition. Application of the revised Duke criteria was useful in confirming the diagnosis of IE.
Motor-Cortical Functional Connectivity Analysis Based on ECoG Signals of Finger Flexion

Multi-channel ECoG signals are directly recorded from the surface of brain during finger flexion. Here they are used to construct brain functional networks based on phase synchronization theory. The channels of ECoG signals are considered as the nodes of brain functional networks, and the interactions among the channels suggest the connectivity of brain functional networks. The edge between two different channels exists only if the phase coupling index is beyond a certain threshold. We built the brain functional networks under the resting and task states and uncover that the cluster coefficients get larger when brain is executing motor task, which means that neighbors of a node prefer to be mutually connected to form more clustered and localized networks. Furthermore, the connectivity of networks is better under the task state. These results suggest that the modularity of brain functional networks emerges to the internal enhanced correlation and localization when the cognitive activity of brain is acting.
Persistence of Upper-Airway Symptoms During CPAP Compromises Adherence at 1 Year

BACKGROUND: The most common adverse effects of CPAP are related to the upper airways. We evaluated upper-airway symptoms before and after a CPAP trial as well as their effect on CPAP adherence. We also evaluated the effect of humidification added to CPAP therapy on upper-airway symptoms. METHODS: We followed for 1 y 536 subjects with obstructive sleep apnea scheduled consecutively for CPAP initiation. Subjects completed visual analog questionnaires on nasal stuffiness, rhinorrhea, and mouth dryness (0 = no symptoms, 100 = severe symptoms). RESULTS: Before CPAP initiation, mean nasal stuffiness score was 29.6 ± 24.9, rhinorrhea score was 16.0 ± 21.7, and mouth dryness score was 43.8 ± 33.1. In subjects who quit CPAP treatment before the 1-y follow-up, the increase in rhinorrhea score during CPAP initiation was significant, 5.3 (95% CI 0.5–9.5, P = .02), and in those using CPAP at 1 y, nasal stuffiness score and mouth dryness score decreased significantly during initiation, −5.1 (95% CI −7.9 to −2.4, P < .001) and −21.2 (−25.5 to −17.4, P < .001). Mouth dryness score decreased significantly with CPAP regardless of humidification: change with humidification, −18.1 (95% CI −22.1 to −14.3), P < . 001; change without, −10.5 (95% CI −16.9 to −4.1), P = . 002. Humidification also prevented the aggravation of rhinorrhea (change, −0.4 [95% CI −2.6 to 1.9], P = .75) and alleviated nasal stuffiness (change −5.3 [95% CI −7.8 to −2.6], P < .001) with CPAP, whereas its absence induced a significant rise in symptom scores: change in rhinorrhea, 11.5 (95% CI 7.1–16.7), P < . 001; change in nasal stuffiness, 8.5 (95% CI 3.9–13.5, P < .001). CONCLUSIONS: The severity of upper-airway symptoms before CPAP does not predict CPAP use at 1 y, whereas CPAP non-users at 1 y had smaller or no alleviation in symptom scores during initiation compared with those who continued CPAP treatment.
Toward Solving the UV Puzzle

Decreases in stratospheric ozone caused by chlorofluorocarbons released into the atmosphere lead to an increase in harmful ultraviolet (UV) light received at Earth's surface. But UV and ozone also vary naturally as a result of changes in solar activity. In their Perspective, [ Rozema et al . ][1] chart recent efforts to elucidate the relation among the solar UV spectrum, ozone concentrations, and harmful surface UV on decadal and longer time scales. Biological proxies (phenolic compounds in pollen and spores) can be used to reconstruct historical UV-B and total ozone. [1]: http://www.sciencemag. org/cgi/content/full/296/5573/1621
Automated conserved non-coding sequence (CNS) discovery reveals differences in gene content and promoter evolution among grasses

Conserved non-coding sequences (CNS) are islands of non-coding sequence that, like protein coding exons, show less divergence in sequence between related species than functionless DNA. Several CNSs have been demonstrated experimentally to function as cis-regulatory regions. However, the specific functions of most CNSs remain unknown. Previous searches for CNS in plants have either anchored on exons and only identified nearby sequences or required years of painstaking manual annotation. Here we present an open source tool that can accurately identify CNSs between any two related species with sequenced genomes, including both those immediately adjacent to exons and distal sequences separated by >12 kb of non-coding sequence. We have used this tool to characterize new motifs, associate CNSs with additional functions, and identify previously undetected genes encoding RNA and protein in the genomes of five grass species. We provide a list of 15,363 orthologous CNSs conserved across all grasses tested. We were also able to identify regulatory sequences present in the common ancestor of grasses that have been lost in one or more extant grass lineages. Lists of orthologous gene pairs and associated CNSs are provided for reference inbred lines of arabidopsis, Japonica rice, foxtail millet, sorghum, brachypodium, and maize.
Modeling of Electric Arc Furnaces ( EAF ) with electromagnetic stirring

Electromagnetic stirring can play an important role in modern Electric Arc Furnaces (EAF), as they often operate far from equilibrium conditions, with tap-to-tap times of 45 minutes or less, high electric power input and significant energy additions from fuel and oxygen. Numerical modeling is used extensively in ABB’s current efforts to optimize the EAF process with electromagnetic stirring. The modeling approach uses a Finite-Element method (FEM) for computing the forces generated by the electromagnetic stirrer, whereas the resulting flow properties, heat and mass transfer in the system is computed using a Finite-Volume (FVM) flow solver. The paper presents the numerical model in greater detail and discusses some important results. We show that electromagnetic stirring gives a more than ten-fold increase of flow velocities and circulation, compared with a flow driven by natural convection alone. The global circulation created by electromagnetic stirring dramatically reduces temperature differences in the melt, thus reducing super-heating of the melt surface and risks for cold regions. Efficient mixing of chemical species, together with even temperatures, is beneficial for efficiency and controllability of the chemical reactions in the slag-metal interface.
Increased thromboembolic complications with concurrent tamoxifen and chemotherapy in a randomized trial of adjuvant therapy for women with breast cancer. National Cancer Institute of Canada Clinical Trials Group Breast Cancer Site Group.

PURPOSE AND METHODS Associations between thromboembolism and malignancy, usually widespread, and between thromboembolism and hormonal and/or chemotherapy have been previously reported. We performed a randomized trial of tamoxifen 30 mg/d for 2 years (T) versus T plus 6 months of intravenous chemotherapy with cyclophosphamide, methotrexate, and fluorouracil (CMF) for postmenopausal women with involved axillary nodes and positive estrogen receptor (ER) or progesterone receptor (PgR) status following primary therapy for breast cancer. RESULTS We observed one or more thromboembolic events in 48 of 353 women (13.6%) allocated to receive T plus CMF in comparison to five of 352 women (2.6%) randomized to receive T alone (P < .0001). Six women in the T plus CMF arm, but none randomized to receive T alone, suffered two thromboembolic events while an study therapy. There were also significantly more women who developed severe (grade 3 to 5) thromboembolic events in the T plus CMF arm than in the T arm (34 v five; P < .0001). Most thromboembolic events (39 of 54) occurred while women were actually receiving chemotherapy (P < .0001). Thromboembolic complications resulted in more days in hospital and more deaths than any other complication of therapy, including infection, in this trial. CONCLUSION Thromboembolism related to the addition of CMF chemotherapy to tamoxifen as adjuvant therapy in this group of women represents a relatively common and serious complication that may outweigh any benefits offered by this additional therapy.