Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of Childhood Domestic Injuries among Joint and Nuclear Families of Karachi

To assess the frequencies and factors of domestic injuries among children aged less than 5 years. This is a cross sectional study, in which parents who have child less than 5 years of age were targeted. A total of 246 participants had provided satisfactory information and they were approached by non-probability purposive sampling technique from January 2016 to June 2016. The data was entered in Excel and then imported to SPSS 19.0 for inferential analysis. In this study, 89.8% (n = 221) mothers and 10.2% (n = 25) father who had participated. 52.08% (n = 123) parents were from joint family. The different types of domestic injuries faced by children were fall (52%), sharp cut (36%), and burn (31%) and Temporary fever, rashes and scratches were the most common consequence of domestic injury as experienced by 57% children. No any significant difference (p > 0.05) in the storage practices of different household hazardous item was observed among the parents living in joint and nuclear family system. Protecting children from domestic injury is a multi-dimensional approach. It needs parent’s education, manufacturer guidance, Government regulation and joint community efforts for proper and safe storage of household items. These measures will aid in reducing the burden of childhood domestic injuries.
Pronounced Hypoperfusion during Spreading Depression in Mouse Cortex

We studied unique cerebral blood flow (CBF) responses to cortical spreading depression in mice using a novel two-dimensional CBF imaging technique, laser speckle flowmetry. Cortical spreading depression caused a triphasic CBF response in both rat and mouse cortex. In rats, mild initial hypoperfusion (approximately 75% of baseline) was followed by a transient hyperemia reaching approximately 220% of baseline. In mice, the initial hypoperfusion was pronounced (40–50% of baseline), and the anticipated hyperemic phase barely reached baseline. The duration of hypoperfusion significantly correlated with the duration of the DC shift. As a possible explanation for the pronounced hypoperfusion, mouse cerebral vessels showed enhanced resistance to relaxation by acetylcholine (3 μM) after K+-induced preconstriction (20, 40, and 80 mM) but dilated normally in response to acetylcholine after preconstriction with U46619, a synthetic thromboxane A2 analog. By contrast, rat vessels dilated readily to acetylcholine after preconstriction by K+. The transient normalization of CBF after hypoperfusion in the mouse was abolished by L-NA but not 7-NI. In summary, the CBF response to cortical spreading depression in mice contrasts with the rat in that the initial hypoperfusion is pronounced, and the hyperemic phase is markedly diminished. The differences in CBF response between species may be in part caused by an increased sensitivity of mouse cerebral vessels to elevated extracellular K+.
β‐Amyloid Peptides Increase the Binding and Internalization of Apolipoprotein E to Hippocampal Neurons

Abstract: The frequency of the ε4 allele of apolipoprotein E(apoE) is increased in late‐onset and sporadic forms of Alzheimer's disease (AD). ApoE also binds to β‐amyloid (Aβ) and both proteins are found in AD plaques. To further investigate the potential interaction of apoE and Aβ in the pathogenesis of AD, we have determined the binding, internalization, and degradation of human apoE isoforms in the presence and absence of Aβ peptides to rat primary hippocampal neurons. We demonstrate that the lipophilic Aβ peptides, in particular Aβ1–42, Aβ1–40, and Aβ25–35, increase significantly apoE‐liposome binding to hippocampal neurons. For each Aβ peptide, the increase was significantly greater for the apoE4 isoform than for the apoE3 isoform. The most effective of the Aβ peptides to increase apoE binding, Aβ25–35, was further shown to increase significantly the internalization of both apoE3‐ and apoE4‐liposomes, without affecting apoE degradation. Conversely, Aβ1–40 uptake by hippocampal neurons was shown to be increased in the presence of apoE‐liposomes, more so in the presence of the apoE4 than the apoE3 isoform. These results provide evidence that Aβ peptides interact directly with apoE lipoproteins, which may then be transported together into neuronal cells through apoE receptors.
Investigating serendipity in recommender systems based on real user feedback

Over the past several years, research in recommender systems has emphasized the importance of serendipity, but there is still no consensus on the definition of this concept and whether serendipitous items should be recommended is still not a well-addressed question. According to the most common definition, serendipity consists of three components: relevance, novelty and unexpectedness, where each component has multiple variations. In this paper, we looked at eight different definitions of serendipity and asked users how they perceived them in the context of movie recommendations. We surveyed 475 users of the movie recommender system, MovieLens regarding 2146 movies in total and compared those definitions of serendipity based on user responses. We found that most kinds of serendipity and all the variations of serendipity components broaden user preferences, but one variation of unexpectedness hurts user satisfaction. We found effective features for detecting serendipitous movies according to definitions that do not include this variation of unexpectedness. We also found that different variations of unexpectedness and different kinds of serendipity have different effects on preference broadening and user satisfaction. Among movies users rate in our system, up to 8.5% are serendipitous according to at least one definition of serendipity, while among recommendations that users receive and follow in our system, this ratio is up to 69%.
Estimation and quantification of human DNA in dental calculus: A pilot study

Context: Identification using DNA has proved its accuracy multiple times in the field of forensic investigations. Investigators usually rely on either teeth or bone as the DNA reservoirs. However, there are instances where the skeletal or dental remains are not available or not preserved properly. Moreover, due to religious beliefs, the family members of the dead do not allow the investigating team to damage the remains for the sole purpose of identification. Aim: To investigate the presence of human DNA in dental calculus and to quantify the amount, if present. Materials and Methods: This prospective single-blinded pilot study included twenty subjects selected from the patients visiting a dental college. The samples of dental calculus were collected from the thickest portion of calculus deposited on the lingual surfaces of mandibular incisors. These samples were decontaminated and subjected to gel electrophoresis for DNA extraction. Results: DNA was found in 85% cases. The amount of DNA varied from 21 to 37 μg/ml of dental calculus. Conclusion: Dental calculus is a rich reservoir of human DNA.
Does Selection Favor Dewlap Colors that Maximize Detectability? A Test with Five Species of Jamaican Anolis Lizards

Abstract: Animal color signals evolve in response to selection by visual systems that perceive them, ambient light spectra that illuminate them, and features of the background against which they are juxtaposed. In Anolis lizards, males use a colorful dewlap, together with head-bobbing displays, to deter conspecific rivals and to attract females. As most anoles are both arboreal and sympatric with one or more congeners, selection should favor dewlap colors that contrast sufficiently with the visual background of foliage to be detectable, and that differ reliably from dewlaps of sympatric congeners to be discriminable. We used spectroradiometry and computational visual modeling for five species of closely related Jamaican anoles to calculate the detection probability of each species' dewlap in each of the species' light habitats. Despite substantial interspecific differences in dewlap colors, as well as moderate differences in habitat light spectra, results of our analyses did not support the prediction that a given species' dewlap should be more detectable in its “own” light habitat than in those of sympatric congeners. Rather, dewlaps tended to perform similarly across most light environments. Our results resemble those reported for Puerto Rican anoles, and we discuss potential reasons why Anolis dewlap color design does not appear to be optimized for specific light habitats.
Prescription pattern of antihypertensive medications and blood pressure control among hypertensive outpatients at the University of Benin Teaching Hospital in Benin City, Nigeria

Background The prevalence of hypertension and attendant cardiovascular disease burden is increasing globally. Auditing antihypertensive prescriptions and assessing patients with hypertension for blood pressure (BP) control are important steps on the path to reducing hypertension-related morbidity, mortality, and health expenditure. This study assessed the prescription pattern of antihypertensive medications and BP control among hypertensive outpatients at the University of Benin Teaching Hospital in Benin City, Nigeria. Methods This was a cross-sectional descriptive study that involved 224 hypertensive patients. Information obtained from participants included sociodemographic data, duration of hypertension, history of diabetes mellitus, and number and classes of antihypertensive medications used. Good BP control was defined as a mean BP less than 140/90mmHg. Results The mean age of hypertensive subjects was 59.6 ± 12.2 years, with a male:female ratio of 1:1.9 and a median duration of hypertension of 5 years. Twenty-four participants (10.7%) had both hypertension and diabetes. The common classes of antihypertensive medications used were diuretics, calcium channel blockers (CCB), and angiotensin converting enzyme inhibitors (ACEIs). Forty participants (17.8%) were on monotherapy, while the rest were on multidrug therapy. The most commonly prescribed antihypertensive combination was diuretic + ACEI/angiotensin receptor blocker (ARB), followed by diuretic + CCB + ACEI/ARB. Good BP control was observed in 120 participants (53.6%). The proportion of patients with good BP control was largest among patients on monotherapy and those with tertiary education, though these observations were not statistically significant. Conclusions The pattern of prescribed antihypertensive medications complied with recommended guidelines. Blood pressure control amongst hypertensive patients was unsatisfactory. More efforts should be geared towards better BP control.
Limit theorems for multiple stochastic integrals

We show that the general stable convergence results proved in Peccati and Taqqu (2007) for generalized adapted stochastic integrals can be used to ob- tain limit theorems for multiple stochastic integrals with respect to independently scattered random measures. Several applications are developed in a companion pa- per (see Peccati and Taqqu, 2008a), where we prove central limit results involving single and double Poisson integrals, as well as quadratic functionals associated with moving average Levy processes.
Revision of the crystal structure of ulrichite , CaCu 2 + ( UO 2 ) ( PO 4 ) 2 4 H 2

The crystal structure of ulrichite, CaCu(UO2)(PO4)2 4H2O (space group P21/c, a = 12.784(3), b = 6.996(1), c = 13.007(3) Å, b = 91.92(1)8, V = 1162.7(4) Å, Z = 4) was redetermined using X-ray diffraction data measured from a twinned crystal with Mo-Ka radiation and a CCD area detector (2510 unique reflections with Fo > 4s(Fo), R1 = 8.8%). Ulrichite crystallizes in space group P21/c rather than C2/m reported previously. The newly determined atomic positions give reasonable coordination polyhedra. One unique Ca atom is irregularly coordinated by eight O atoms (<Ca O> = 2.46 Å). One unique U atom shows a [2+5] coordination with characteristic bond angles and lengths (1.806(11) Å, 1.842(12) Å and five bonds between 2.252(15) and 2.441(11) Å). Furthermore, the structure contains groups in which strongly elongated CuO6 ‘octahedra’ (also describable as CuO4 squares) are cornerlinked to two PO4 tetrahedra via two opposite, equatorial O atoms. Edgeand corner-sharing UO7, CaO8 and PO4 polyhedra form heteropolyhedral sheets parallel to (001) that are linked to adjacent sheets via the CuO6 ‘octahedra’ and hydrogen bonds.
Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of β2-Adrenoceptor Agonists

The contribution of gene expression changes to the adverse and therapeutic effects of β2-adrenoceptor agonists in asthma was investigated using human airway epithelial cells as a therapeutically relevant target. Operational model-fitting established that the long-acting β2-adrenoceptor agonists (LABA) indacaterol, salmeterol, formoterol, and picumeterol were full agonists on BEAS-2B cells transfected with a cAMP-response element reporter but differed in efficacy (indacaterol ≥ formoterol > salmeterol ≥ picumeterol). The transcriptomic signature of indacaterol in BEAS-2B cells identified 180, 368, 252, and 10 genes that were differentially expressed (>1.5- to <0.67-fold) after 1-, 2-, 6-, and 18-hour of exposure, respectively. Many upregulated genes (e.g., AREG, BDNF, CCL20, CXCL2, EDN1, IL6, IL15, IL20) encode proteins with proinflammatory activity and are annotated by several, enriched gene ontology (GO) terms, including cellular response to interleukin-1, cytokine activity, and positive regulation of neutrophil chemotaxis. The general enriched GO term extracellular space was also associated with indacaterol-induced genes, and many of those, including CRISPLD2, DMBT1, GAS1, and SOCS3, have putative anti-inflammatory, antibacterial, and/or antiviral activity. Numerous indacaterol-regulated genes were also induced or repressed in BEAS-2B cells and human primary bronchial epithelial cells by the low efficacy LABA salmeterol, indicating that this genomic effect was neither unique to indacaterol nor restricted to the BEAS-2B airway epithelial cell line. Collectively, these data suggest that the consequences of inhaling a β2-adrenoceptor agonist may be complex and involve widespread changes in gene expression. We propose that this genomic effect represents a generally unappreciated mechanism that may contribute to the adverse and therapeutic actions of β2-adrenoceptor agonists in asthma.
Treatment Outcomes and Lessons Learned From Transilluminated Powered Phlebectomy for Varicose Veins in 1034 Patients

Introduction: Transilluminated powered phlebectomy (TIPP) is a minimally invasive technique of varicose vein removal, which combines irrigated illumination with tumescent anesthesia for ablation of superficial varicosities and endoscopic-powered venous resection. The objective of this study was to analyze treatment outcomes of this treatment modality. Methods: A retrospective evaluation of prospectively collected data from all patients undergoing TIPP procedure for symptomatic varicose veins during a recent 12-year period was performed. Pertinent patient demographics, disease classification, perioperative complications, quality of life, and treatment outcomes were collected and analyzed. Results: A total of 1167 limbs in 1034 patients (mean age, 52.4 years) were treated during the study period. The mean procedure time was 18.4 ± 8.9 minutes (range, 6.0-82.0 minutes). The mean number of incisions for TIPP procedure was 6.3 ± 3.6. All TIPP procedures were technically successful, and no patient required conversion to hook stab phlebectomy. Fifteen (1.5%) patients developed residual or recurrent varicosities, which were treated with sclerotherapy during the follow-up period. Postoperative complications included hematoma at 2 weeks (5.8%), ecchymosis at 2 weeks (32.9%), saphenous neuropathy (0.3%), cellulitis (1.0%), and skin pigmentation (1.9%). There was no postoperative deep vein thrombosis or mortality. Conclusions: Transilluminated powered phlebectomy is an effective method for varicose vein removal and is associated with high clinical success and excellent cosmetic results. Meticulous technical steps are critical in achieving successful outcomes while minimizing complications. Technical considerations and lessons learned from our experiences are discussed in this report.
Comparison of Changes in Incisors Position in Cases Treated with Damon Self-Ligating and Conventional Fixed Appliances

Objective: This study aimed to compare the changes in maxillary and mandibular incisors position in cases treated with Damon self-ligating and conventional fixed appliances. Methods: The sample comprised 51 patients with Class I malocclusion, mild to moderate crowding, treated without extractions, divided into 2 groups: Group 1 consisted of 20 patients treated with Damon self-ligating appliance, with a mean initial age of 15.00 years, treated for a mean period of 2.01 years; and Group 2 comprised 31 patients treated with conventional fixed appliances, with a mean initial age of 14.98 years, treated for a mean period of 1.81 years. The initial and final cephalograms of each patient were measured. The intergroup comparisons were performed with independent t or Mann-Whitney tests. Results: Both groups showed a mild protrusion and a buccal inclination of the maxillary and mandibular incisors, with no statistically significant difference between them. Conclusion: The changes in maxillary and mandibular incisors position were similar between the groups treated with Damon self-ligating and conventional fixed appliances.
Context dependency in biodiversity patterns of central German stream metacommunities

Summary Context dependency is an emerging topic that is challenging our understanding of the factors shaping biodiversity in metacommunities. River networks and other dendritic systems provide unique systems for examining variation in the processes shaping biodiversity between different metacommunities. We examined biodiversity patterns in five benthic invertebrate data sets, from two catchments in central Germany, with the aim of exploring context dependency in these systems. We used variance partitioning to disentangle the variation explained in three biodiversity metrics: taxonomic richness, Simpson's diversity and local contribution to beta diversity (LCBD; a measure of the uniqueness of a site). As explanatory variables, we used proxies of network position (i.e. catchment size and altitude) and habitat conditions. Contrary to our expectation, we found no evidence of a decline in LCBD downstream in our study. Local habitat conditions and catchment land use played a much stronger role than catchment size and altitude in explaining variation in the three biodiversity metrics. Observed patterns were highly variable between different data sets in our study. These findings suggest that factors shaping biodiversity patterns in these systems are highly context dependent and less related to their position along the river network than local habitat conditions. Given the clear context dependency between data sets, we urge researchers to focus on disentangling the factors driving the high levels of variability between individual systems through the study of a number of replicate, rather than single, metacommunities.
Cosmic-ray energy spectrum and composition up to the ankle - the case for a second Galactic component

We have carried out a detailed study to understand the observed energy spectrum and composition of cosmic rays with energies up to ~10^18 eV. Our study shows that a single Galactic component with subsequent energy cut-offs in the individual spectra of different elements, optimised to explain the observed spectra below ~10^14 eV and the knee in the all-particle spectrum, cannot explain the observed all-particle spectrum above ~2x10^16 eV. We discuss two approaches for a second component of Galactic cosmic rays -- re-acceleration at a Galactic wind termination shock, and supernova explosions of Wolf-Rayet stars, and show that the latter scenario can explain almost all observed features in the all-particle spectrum and the composition up to ~10^18 eV, when combined with a canonical extra-galactic spectrum expected from strong radio galaxies or a source population with similar cosmological evolution. In this two-component Galactic model, the knee at ~ 3x10^15 eV and the second knee at ~10^17 eV in the all-particle spectrum are due to the cut-offs in the first and second components, respectively. We also discuss several variations of the extra-galactic component, from a minimal contribution to scenarios with a significant component below the ankle (at ~4x10^18 eV), and find that extra-galactic contributions in excess of regular source evolution are neither indicated nor in conflict with the existing data. Our main result is that the second Galactic component predicts a composition of Galactic cosmic rays at and above the second knee that largely consists of helium or a mixture of helium and CNO nuclei, with a weak or essentially vanishing iron fraction, in contrast to most common assumptions. This prediction is in agreement with new measurements from LOFAR and the Pierre Auger Observatory which indicate a strong light component and a rather low iron fraction between ~10^17 and 10^18 eV.
New transcriptional-based insights into the pathogenesis of desmoplastic small round cell tumors (DSRCTs)

To gain new insights into desmoplastic small round cell tumors (DSRCTs) by means of gene expression profiling (GEP). Formalin-fixed, paraffin-embedded surgical specimens obtained from seven pretreated DSRCT patients were interrogated using GEP complemented by immunohistochemistry, a cancer stem cell array, and miRNA in situ hybridisation, including the combined chimera modules miRNA-200/ZEB1 and miRNA-34/SLUG. The chimera modules divided the cases into three classes that respectively recapitulated the traits of mesenchymal epithelial reverse transition (MErT), epithelial mesenchymal transition (EMT), and hybrid/partial EMT. This indicates a close correlation between the reprogramming governed by EMT regulators and DSRCT biology, which was further confirmed by miRNA-21 and is consistent with the broad morphological spectrum of DSRCTs. Starting from the miRNA-200/ZEB1 axis, we also found that DSRCTs carry a signature of immunological ignorance that is not responsive to PD-L1 blockade. Evidence that the up-regulation of miRNA-200 and E-cadherin, and quite a high level of miRNA-21 expression segregate with the MErT supports the idea that, in addition to the hybrid/partial state, MErT is also enriched in stemness: the androgen-positive cases, whose stemness traits were confirmed by stem cell arrays, all fell into these two classes. Our findings also confirmed that tumoral cell PDGFRA expression correlates with desmoplasia, and demonstrated the co-expression of PDGFRA and ISLR/Meflin, another marker of pluripotency. Despite the limited number of cases, these findings provide unexpectedly relevant information concerning the pathogenesis of DSRCTs, and prove the validity of miRNA-based chimera circuit modelling in the clinico-pathological setting.