Miracle-dz/UniFAR-FTUs huggingface dataset:
Wegener's granulomatosis: clinical course in 108 patients with renal involvement.

BACKGROUND The aim of this study was to evaluate the clinical course of patients with Wegener's granulomatosis and renal involvement, with special reference to relapse rate, renal and patient survival and morbidity from serious infections. METHODS A retrospective analysis was carried out of 108 patients presenting with Wegener's granulomatosis and active renal disease in eight hospitals in Norway between 1988 and 1998. Multivariate analysis was used to investigate whether selected variables predicted relapse, renal and patient survival and serious infections. RESULTS Median follow-up was 41.5 months. Twenty-two patients (20.4%) were admitted with a need for dialysis. Complete remission was obtained in 81.5% after a median of 4 months, and 54.7% relapsed after a median of 22. 5 months. Two- and five-year renal survival was 86 and 75%, respectively, and 22.8% developed end-stage renal disease (ESRD). Two- and five-year patient survival was 88 and 74%, respectively, and the cumulative mortality was 3.8 times higher than expected. The relative risk of relapse increased with the use of intravenous pulse cyclophosphamide compared with daily oral cyclophosphamide. Initial renal function predicted renal survival, and low serum albumin and high age at treatment start increased the mortality risk. Thirty one per cent of the patients were hospitalized for serious infections during follow-up. Old age increased the risk of having an infection. CONCLUSIONS The current treatment of Wegener's granulomatosis does not prevent relapse, development of ESRD and serious treatment-induced infections in a considerable fraction of the patients. Alternative strategies for the management of this disease will be an important objective for further studies.
Influences of Cognitive Control on Numerical Cognition - Adaptation by Binding for Implicit Learning

Recently, an associative learning account of cognitive control has been suggested (Verguts & Notebaert, 2009). In this so-called adaptation by binding theory, Hebbian learning of stimulus-stimulus and stimulus-response associations is assumed to drive the adaptation of human behavior. In this study, we evaluated the validity of the adaptation-by-binding account for the case of implicit learning of regularities within a stimulus set (i.e., the frequency of specific unit digit combinations in a two-digit number magnitude comparison task) and their association with a particular response. Our data indicated that participants indeed learned these regularities and adapted their behavior accordingly. In particular, influences of cognitive control were even able to override the numerical distance effect--one of the most robust effects in numerical cognition research. Thus, the general cognitive processes involved in two-digit number magnitude comparison seem much more complex than previously assumed. Multi-digit number magnitude comparison may not be automatic and inflexible but influenced by processes of cognitive control being highly adaptive to stimulus set properties and task demands on multiple levels.
Ju n 20 02 Consciousness : The rules of engagement

We examine the role of a conscious observer in a typical quantum mechanical measurement. Four rules are given that govern stochastic choice and state reduction in several cases of continuous and intermittent observation. It is found that consciousness always accompanies a state reduction leading to observation, but its presence is not sufficient to ‘cause’ a reduction. The distinction is clarified and codified by the rules that are given below. This is the first of several papers that lead to an experimental test of the rules, and of the “parallel principle” that is described elsewhere.
BOLD-Perfusion Coupling during Monocular and Binocular Stimulation

Previous studies have suggested that during selective activation of a subset of the zones comprising a columnar system in visual cortex, perfusion increases uniformly in all columns of the system, while increases in oxidative metabolism occur predominantly in the activated columns. This could lead to disproportionately large blood oxygenation level-dependent (BOLD) signal increases for a given flow increase during monocular (relative to binocular) stimulation, due to contributions from columns which undergo large increases in perfusion with little or no change in oxidative metabolism. In the present study, we sought to test this hypothesis by measuring BOLD-perfusion coupling ratios in spatially averaged signals over V1 during monocular and binocular visual stimulation. It was found that, although withholding input to one eye resulted in statistically significant decreases in BOLD and perfusion signals in primary visual cortex, the ratio between BOLD and perfusion increases did not change significantly. These results do not support a gross mismatch between spatial patterns of flow and metabolism response during monocular stimulation.
Proanthocyanidin-Accumulating Cells in Arabidopsis Testa: Regulation of Differentiation and Role in Seed Development Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.014043.

Anthocyanidin reductase encoded by the BANYULS (BAN) gene is the core enzyme in proanthocyanidin (PA) biosynthesis. Here, we analyzed the developmental mechanisms that regulate the spatiotemporal expression of BAN in the developing Arabidopsis seed coat. PA-accumulating cells were localized histochemically in the inner integument (seed body and micropyle) and pigment strand (chalaza). BAN promoter activity was detected specifically in these cells. Gain-of-function experiments showed that an 86-bp promoter fragment functioned as an enhancer specific for PA-accumulating cells. Mutations in regulatory genes of PA biosynthesis abolished BAN promoter activity (transparent testa2 [tt2], tt8, and transparent testa glabra1 [ttg1]), modified its spatial pattern (tt1 and tt16), or had no influence (ttg2), thus revealing complex regulatory interactions at several developmental levels. Genetic ablation of PA-accumulating cells targeted by the BAN promoter fused to BARNASE led to the formation of normal plants that produced viable yellow seeds. Importantly, these seeds had no obvious defects in endosperm and embryo development.
Eicosapentaenoic acid attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling

Cigarette smoking causes chronic lung inflammation that is mainly regulated by redox-sensitive pathways. Our previous studies have demonstrated that cigarette smoke (CS) activates reactive oxygen species (ROS)-sensitive mitogen-activated protein kinases (MAPKs)/nuclear factor-κB (NF-κB) signaling resulting in induction of lung inflammation. Eicosapentaenoic acid (EPA), a major type of omega-3 polyunsaturated fatty acid, is present in significant amounts in marine-based fish and fish oil. EPA has been shown to possess antioxidant and anti-inflammatory properties in vitro and in vivo. However, whether EPA has similar beneficial effects against CS-induced lung inflammation remains unclear. Using a murine model, we show that subchronic CS exposure for 4 weeks caused pulmonary inflammatory infiltration (total cell count in bronchoalveolar lavage fluid (BALF), 11.0-fold increase), increased lung vascular permeability (protein level in BALF, 3.1-fold increase), elevated levels of chemokines (11.4–38.2-fold increase) and malondialdehyde (an oxidative stress biomarker; 2.0-fold increase) in the lungs, as well as lung inflammation; all of these CS-induced events were suppressed by daily supplementation with EPA. Using human bronchial epithelial cells, we further show that CS extract (CSE) sequentially activated NADPH oxidase (NADPH oxidase activity, 1.9-fold increase), increased intracellular levels of ROS (3.0-fold increase), activated both MAPKs and NF-κB, and induced interleukin-8 (IL-8; 8.2-fold increase); all these CSE-induced events were inhibited by pretreatment with EPA. Our findings suggest a novel role for EPA in alleviating the oxidative stress and lung inflammation induced by subchronic CS exposure in vivo and in suppressing the CSE-induced IL-8 in vitro via its antioxidant function and by inhibiting MAPKs/NF-κB signaling.
Heart Sounds Classification using Feature Extraction of Phonocardiography Signal

The Phonocardiogram (PCG) signals contain very useful information about the condition of the heart. By analyzing these signals, early detection and diagnosis of heart diseases can be done. It is also very useful in the case of infants, where ECG recording and other techniques are difficult to implement. In this paper, a classification method is proposed to classify normal and abnormal heart sound signals having murmurs without getting into the cumbersome process of segmenting fundamental heart sounds (FHS) using Electrocardiogram (ECG) gating. The proposed algorithm can be easily implemented on latest electronic stethoscopes, and therefore the unnecessary ECG can be avoided.
Characterizing Fluorine and Chlorine Atom Flow Rates Using

The production of F and Cl atoms in an electrical discharge of F 2 or Cl 2 has been examined in a flow reactor. A tunable diode laser was used to probe the concentration and translational temperature of I atoms produced by F and Cl atom reactions with HI. Kinetic modeling codes were used to determine the discharge efficiencies from the titration plots and the observed trends for atom concentration as a function of F 2 or Cl 2 and pressure. These calculations indicate that the de discharge used in these experiments is 100% efficient for F 2 flow rates ≤0.5 mmol s -1 and reactor pressure ≤20 torr. The highest F 2 -free F atom flow rate that we can generate is 1.0 mmol s -1 . Preliminary data for the Cl 2 discharge indicate that this is a much less efficient source of Cl atoms with yields of less than 50%.
Effects of Cardiopulmonary Bypass on Propofol Pharmacokinetics and Bispectral Index During Coronary Surgery

PURPOSE Cardiopulmonary bypass is known to alter propofol pharmacokinetics in patients undergoing cardiac surgery. However, few studies have evaluated the impact of these alterations on postoperative pharmacodynamics. This study was designed to test the hypothesis that changes in propofol pharmacokinetics increase hypnotic effects after cardiopulmonary bypass. METHODS Twenty patients scheduled for on-pump coronary artery bypass graft (group, n=10) or off-pump coronary artery bypass graft (group, n=10) coronary artery bypass grafts were anesthetized with sufentanil and a propofol target controlled infusion (2.0 μg/mL). Depth of hypnosis was monitored using the bispectral index. Blood samples were collected from the induction of anesthesia up to 12 hours after the end of propofol infusion, at predetermined intervals. Plasma propofol concentrations were measured using high-performance liquid chromatography, followed by a non-compartmental propofol pharmacokinetic analysis. Data were analyzed using ANOVA, considering p<0.05 as significant. RESULTS After cardiopulmonary bypass, despite similar plasma propofol concentrations in both groups, bispectral index values were lower in the on-pump coronary artery bypass graft group. Time to extubation after the end of propofol infusion was greater in the on-pump coronary artery bypass graft group (334 ± 117 vs. 216 ± 85 min, p = 0.04). Patients undergoing cardiopulmonary bypass had shorter biological (1.82 ± 0.5 vs. 3.67 ± 1.15h, p < 0.01) and terminal elimination (6.27 ± 1.29 vs. 10.5h ± 2.18, p < 0.01) half-life values, as well as higher total plasma clearance (28.36 ± 11.40 vs.18.29 ± 7.67 mL/kg/min, p = 0.03), compared to patients in the off-pump coronary artery bypass graft group. CONCLUSION Aside from the increased sensitivity of the brain to anesthetics after cardiopulmonary bypass, changes in propofol pharmacokinetics may contribute to its central nervous system effects.
Elders who delay medication because of cost: health insurance, demographic, health, and financial correlates.

PURPOSE Prescription medication use is essential to the health and well-being of many elderly persons. However, the cost of medications may be prohibitive and contribute to noncompliance with medical recommendations. This study identifies community-dwelling elders who reported a delay in medication use because of prescription medication cost. DESIGN AND METHODS This was a cross-sectional study of a nationwide sample of 6,535 elders participating in the Asset and Health Dynamics Among the Oldest Old (AHEAD) study. Participants reported if they had taken less medication than prescribed or if they had not filled prescriptions because of cost in the past 2 years. This response was then compared with the self-report of multiple variables, including demographic, health status, health insurance coverage, and financial variables. RESULTS Elders who were most vulnerable to medication delay as a result of cost included those with Medicare coverage only, low income, high out-of-pocket prescription costs, and poor health as well as African American elders and those aged 65-80 years. IMPLICATIONS This study provides important information about community-dwelling elders that reported a delay in medication use because of cost. As a Medicare prescription benefit has been passed, it will be important to monitor how these changes affect the elders identified at risk for medication delay.
Neonatal outcomes of preterm infants in breech presentation according to mode of birth in Canadian NICUs

Background Many medical practitioners have adopted the practice of caesarean section for preterm infants in breech presentation based on term infant data. Some studies have highlighted deleterious effects on survival, such as intraventricular haemorrhage and periventricular leucomalacia, while others have reported no difference from the outcomes after vaginal delivery. Objective To compare outcomes of preterm infants of ≤32 weeks' gestational age who were in breech position at the time of birth according to mode of birth in Canadian neonatal intensive care units (NICUs). Settings 29 Canadian NICUs. Design Neonates admitted to participating NICUs in the Canadian Neonatal Network between 2003 and 2007 were included in this retrospective study. Infants who were in breech position at the time of birth were divided into two groups: vaginal birth (VB) and caesarean section (CS). Data on common neonatal outcomes were compared using univariate and multivariate logistic regression. Main outcome measures Neonatal mortality and other neonatal morbidities. Results Of 3552 preterm infants in breech position at birth, 2937 (83%) were delivered by CS and 615 (17%) by VB. Multivariate regression analysis with adjustment for perinatal risk factors indicated that VB was associated with an increased risk of death (OR 1.7; 95% CI 1.3 to 2.3), chronic lung disease (OR 1.5; 95% CI 1.1 to 1.9) and severe retinopathy of prematurity (OR 1.6; 95% CI 1.1 to 2.3). Conclusion Vaginal birth for preterm infants in breech presentation is possibly associated with a higher risk of adverse neonatal outcomes compared with caesarean birth in Canadian NICUs. It is not clear whether adverse outcomes are due to the mode of delivery or whether breech birth is associated with other risk factors, an issue that can only be resolved by a randomised controlled trial.
CrowdSearch: exploiting crowds for accurate real-time image search on mobile phones

Mobile phones are becoming increasingly sophisticated with a rich set of on-board sensors and ubiquitous wireless connectivity. However, the ability to fully exploit the sensing capabilities on mobile phones is stymied by limitations in multimedia processing techniques. For example, search using cellphone images often encounters high error rate due to low image quality. In this paper, we present CrowdSearch, an accurate image search system for mobile phones. CrowdSearch combines automated image search with real-time human validation of search results. Automated image search is performed using a combination of local processing on mobile phones and backend processing on remote servers. Human validation is performed using Amazon Mechanical Turk, where tens of thousands of people are actively working on simple tasks for monetary rewards. Image search with human validation presents a complex set of tradeoffs involving energy, delay, accuracy, and monetary cost. CrowdSearch addresses these challenges using a novel predictive algorithm that determines which results need to be validated, and when and how to validate them. CrowdSearch is implemented on Apple iPhones and Linux servers. We show that CrowdSearch achieves over 95% precision across multiple image categories, provides responses within minutes, and costs only a few cents.
Semantically Enhanced Medical Information Retrieval System: A Tensor Factorization Based Approach

Medical information retrieval plays an increasingly important role to help physicians and domain experts to better access medical-related knowledge and information, and support decision making. Integrating the medical knowledge bases has the potential to improve the information retrieval performance through incorporating medical domain knowledge for relevance assessment. However, this is not a trivial task due to the challenges to effectively utilize the domain knowledge in the medical knowledge bases. In this paper, we proposed a novel medical information retrieval system with a two-stage query expansion strategy, which is able to effectively model and incorporate the latent semantic associations to improve the performance. This system consists of two parts. First, we applied a heuristic approach to enhance the widely used pseudo relevance feedback method for more effective query expansion, through iteratively expanding the queries to boost the similarity score between queries and documents. Second, to improve the retrieval performance with structured knowledge bases, we presented a latent semantic relevance model based on tensor factorization to identify semantic association patterns under sparse settings. These identified patterns are then used as inference paths to trigger knowledge-based query expansion in medical information retrieval. Experiments with the TREC CDS 2014 data set: 1) showed that the performance of the proposed system is significantly better than the baseline system and the systems reported in TREC CDS 2014 conference, and is comparable with the state-of-the-art systems and 2) demonstrated the capability of tensor-based semantic enrichment methods for medical information retrieval tasks.
Infantile systemic hyalinosis: A case report and review of literature

We report a case of infantile systemic hyalinosis in a 3.5-month-old male child born out of consanguineous marriage. He presented with multiple brownish raised lesions over bony prominences. He had also developed difficulty in movement of limbs and as a result developed severe flexion joint contractures. There was history of similar complaints in elder sibling who died at the age of 5 months due to repeated episodes of pneumonia. Skin biopsy from one of the papulonodular lesions showed increased amount of amorphous hyaline matrix, which was Periodic Acid Schiff positive with scattered fibroblasts. Though classical, we report this case for its rarity in western India.
Transcriptome Responses of Insect Fat Body Cells to Tissue Culture Environment

Tissue culture is performed to maintain isolated portions of multicellular organisms in an artificial milieu that is outside the individual organism and for considerable periods of time; cells derived from cultured explants are, in general, different from cells of the corresponding tissue in a living organism. The changes in cultured tissues that precede and often explain the subsequent cell proliferation of explant-derived cells have been partially studied, but little is known about the molecular and genomic basis of these changes. Comparative transcriptomics of intact and cultured (90 hours in MGM-450 insect medium) Bombyx mori tissues revealed that fewer genes represented a larger portion of the transcriptome of intact fat body tissues than of cultured fat body tissues. This analysis also indicated that expression of genes encoding sugar transporters and immune response proteins increased during culture and that expression of genes encoding lipoproteins and cuticle proteins decreased during culture. These results provide support for hypotheses that cultured tissues respond immunologically to surgery, adapt to the medium by accelerating sugar uptake, and terminate their identity as part of an intact organism by becoming independent of that organism.
The semi-algebra low-density parity-check codes

In this paper, the construction of semi-algebra Low-density parity-check (LDPC) code with an arbitrary block length is presented. The encoding circuit is based on the original semi-algebra design and users can have the choice of using the matrix pattern and various code rates to design for different communication applications. Especially, a novel girth scheme named Adaptive Slope Group (ASG) is proposed for the semi-algebra code design with the large girth and maximum minimum distance. We can compare the performance of this novel semi-algebra LDPC code against the Shannon limit for several rates. The simulation results show our codes can perform a large coding gain at high SNRs with BPSK modulation over AWGN channels. However, column weight j is not random, only for j=2.
“Split ADC” Calibration for All-Digital Correction of Time-Interleaved ADC Errors

The ldquosplit analog-to-digital converter (ADC)rdquo architecture enables fully digital calibration and correction of offset, gain, and aperture-delay mismatch errors in time-interleaved ADCs. The calibration of M interleaved ADCs requires 2M + 1 half-sized ADCs, a minimal increase in analog complexity. Each conversion is performed by a pair of half-sized ADCs, generating two independent outputs that are digitally corrected using estimates of offset, gain, and aperture-delay errors. The ADC outputs are averaged to produce the ADC output code. The difference of the outputs is used in a calibration algorithm that estimates the error in the correction parameters. Any nonzero difference drives a least-mean-square feedback loop toward zero difference, which can only occur when the average error in each correction parameter is zero. A simulation of a 4 : 1-time-interleaved 16-bit 12-MSps successive-approximation-register ADC shows calibration convergence within 400 000 samples.