Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of CTX-M-Type and PER Extended-Spectrum β-Lactamases Among Klebsiella spp. Isolated From Clinical Specimens in the Teaching Hospital of Kashan, Iran

Background: Extended-spectrum β-lactamases (ESBLs) is one of the most important mechanisms of resistance to β-lactams especially among Enterobacteriaceae family including Klebsiella spp. Different types of extended-spectrum β-lactamases including CTX-M-type and PER enzymes are identified among gram negative bacteria. Objectives: The current study aimed to determine the prevalence of CTX-M-type and PER extended-spectrum β-lactamases among Klebsiella spp. isolated from clinical specimens in the teaching hospital of Kashan, Iran. Patients and Methods: One hundred Klebsiella spp. were isolated from clinical specimens of hospitalized patients at Shahid-Beheshti hospital from December 2012 to November 2013. Disk diffusion method was used to determine the susceptibility of these isolates to 14 different antimicrobial agents; disks were purchased from MAST company (United Kingdom). The phenotypic double disk synergy confirmatory test was used to screen the isolates to produce extended-spectrum β-lactamase. DNAs of isolates were extracted using boiling method and PCR assay was used to characterize the blaCTX-M type and blaPER genes. The purified PCR products were sent to Macrogen research company (Korea) for sequencing. Results: Of the total 100 Klebsiella isolates, %93 was susceptible to imipenem. Resistance to ampicillin, ceftazidime, ceftriaxone, aztreonam and cefotaxime was (92%), (67%), (65%), (64%) and (59%), respectively. The phenotypic confirmatory test (PCT) confirmed that 35% (n = 35) of the isolates were ESBL-producing Klebsiella strains. The prevalence of blaCTX-M type and blaRER genes among Klebsiella isolates were 28% (n = 28) and 9% (n = 9), respectively. Conclusions: The prevalence of ESBL-producing Klebsiella strains in Shahid-Beheshti hospital in Kashan has increased. The study concluded that there was a high prevalence of the blaCTX-M type gene among ESBL positive isolates.
Bayesian optimization under mixed constraints with a slack-variable augmented Lagrangian

An augmented Lagrangian (AL) can convert a constrained optimization problem into a sequence of simpler (e.g., unconstrained) problems, which are then usually solved with local solvers. Recently, surrogate-based Bayesian optimization (BO) sub-solvers have been successfully deployed in the AL framework for a more global search in the presence of inequality constraints; however, a drawback was that expected improvement (EI) evaluations relied on Monte Carlo. Here we introduce an alternative slack variable AL, and show that in this formulation the EI may be evaluated with library routines. The slack variables furthermore facilitate equality as well as inequality constraints, and mixtures thereof. We show how our new slack "ALBO" compares favorably to the original. Its superiority over conventional alternatives is reinforced on several mixed constraint examples.
Trade Policy and Industrial Sector Responses: Using Evolutionary Models to Interpret the Evidence

Firm- and plant-level empirical studies typically find that trade liberalization squeezes price-cost margins among import-competing firms, that this heightened competitive pressure induces productivity gains among these same firms, and that further efficiency gains come from market share reallocations. Using a computable industrial evolution model to simulate the dynamic effects of import competition, we demonstrate what types of managerial behavior, long-term transition paths and welfare effects are consistent with this set of stylized facts.
Analytical Calculation of the Magnetic Vector Potential of an Axisymmetric Solenoid in the Presence of Iron Parts

This paper presents an analytical calculation method for the computation of the magnetic vector potential of an axisymmetric solenoid in the presence of an iron shield and a ferromagnetic core. The proposed method can be used as a fast analytical computation technique for accelerating the design optimization process of the solenoid systems. In this paper, the analysis of the current carrying coil in the presence of the ferromagnetic materials is treated as a boundary value problem. The solution approach is based on partitioning the solution domain into distinct regions. The general form of the solution to Maxwell's equation in each region along with the corresponding boundary conditions is obtained using the Fourier analysis and the separation of variables. The final solution to the boundary value problem is constituted by considering the continuity of the magnetic vector potential, as well as the magnetic field, on the interfaces between the regions. Finally, the proposed analytical computation method is applied on an electromagnetic actuator. The magnetic vector potential is computed over the entire solution domain, and the result is compared with that of the finite-element method.
Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly

T1736 is a novel phosphorylation site on the integrin β4 subunit that is phosphorylated downstream of protein kinase C and EGF receptor activation and is a substrate for protein kinase D1 in vitro and in cells. It contributes to the regulation of HD dynamics through modulating the association of β4 with plectin.
Tidal Torques and the Orientation of Nearby Disk Galaxies

We use numerical simulations to investigate the orientation of the angular momentum axis of disk galaxies relative to their surrounding large-scale structure. We find that this is closely related to the spatial configuration at turnaround of the material destined to form the galaxy, which is often part of a coherent two-dimensional slab crisscrossed by filaments. The rotation axis is found to align very well with the intermediate principal axis of the inertia momentum tensor at this time. This orientation is approximately preserved during the ensuing collapse, so that the rotation axis of the resulting disk ends up lying on the plane traced by the protogalactic material at turnaround. This suggests a tendency for disks to align themselves so that their rotation axis is perpendicular to the minor axis of the structure defined by surrounding matter. One example of this trend is provided by our own Galaxy, where the Galactic plane is almost at right angles with the supergalactic plane (SGP) drawn by nearby galaxies; indeed, the SGP latitude of the north Galactic pole is just 6°. We have searched for a similar signature in catalogs of nearby disk galaxies, and we find a significant excess of edge-on spiral galaxies (for which the orientation of the disk rotation axis may be determined unambiguously) highly inclined relative to the SGP. This result supports the view that disk galaxies acquire their angular momentum as a consequence of early tidal torques acting during the expansion phase of the protogalactic material.
Mapping Cortico-Striatal Connectivity onto the Cortical Surface: A New Tractography-Based Approach to Study Huntington Disease

Huntington disease (HD) is associated with early and severe damage to the basal ganglia and particularly the striatum. We investigated cortico-striatal connectivity modifications occurring in HD patients using a novel approach which focuses on the projection of the connectivity profile of the basal ganglia onto the cortex. This approach consists in computing, for each subcortical structure, surface connectivity measures representing its strength of connections to the cortex and comparing these measures across groups. In this study, we focused on Huntington disease as an application of this new approach. First, surface cortico-striatal connectivity measures of a group of healthy subjects were averaged in order to infer the “normal” connectivity profile of the striatum to the cortex. Second, a statistical analysis was performed from the surface connectivity measures of healthy subjects and HD patients in order to detect the cortical gyri presenting altered cortico-striatal connectivity in HD. Lastly, percentage differences of connectivity between healthy subjects and patients were inferred, for each nucleus of the striatum, from the connectivity measures of the cortical gyri presenting a significant connectivity difference between the two groups. These percentage differences characterize the axonal disruptions between the striatum and the cortex occurring in HD. We found selective region-specific degeneration of cortical connections predominating for associative and primary sensorimotor connections and with relative preservation of limbic connections. Our method can be used to infer novel connectivity-based markers of HD pathological process.
Nephrology Dialysis Transplantation Ace Dd Genotype Is More Susceptible than Ace Ii and Id Genotypes to the Antiproteinuric Effect of Ace Inhibitors in Patients with Proteinuric Non-insulin-dependent Diabetes Mellitus

24.8±23.9%, P<0.05). There were no statistically significant correlations between the levels of baseline Background. ACE polymorphism, especially genotype DD or D allele, may be involved in the progression of proteinuria and albuminuria and the magnitudes of the reduction of proteinuria and albuminuria under diabetic nephropathy. It may also have different effects on the reduction of proteinuria by ACE inhibitors in ACE inhibition (P>0.05). Conclusions. Our results suggest that the ACE gene patients with proteinuria. We investigated the relationship between ACE gene polymorphism and antipro-polymorphism might have a role in determining the responsiveness to the antiproteinuric effect of ACE teinuric effect of ACE inhibitors (Benazepril 10 mg/day or Perindopril 4 mg/day) in 83 NIDDM patients inhibition in proteinuric NIDDM patients. with overt proteinuria (urinary protein excretion over 500 mg/day). Methods. We recruited NIDDM patients with overt proteinuria from our renal clinic. Before entry, previously used ACE inhibitors were withdrawn for at least 2 weeks and baseline proteinuria and albuminuria were
Bayesian coalescent inference of major human mitochondrial DNA haplogroup expansions in Africa

Past population size can be estimated from modern genetic diversity using coalescent theory. Estimates of ancestral human population dynamics in sub-Saharan Africa can tell us about the timing and nature of our first steps towards colonizing the globe. Here, we combine Bayesian coalescent inference with a dataset of 224 complete human mitochondrial DNA (mtDNA) sequences to estimate effective population size through time for each of the four major African mtDNA haplogroups (L0–L3). We find evidence of three distinct demographic histories underlying the four haplogroups. Haplogroups L0 and L1 both show slow, steady exponential growth from 156 to 213 kyr ago. By contrast, haplogroups L2 and L3 show evidence of substantial growth beginning 12–20 and 61–86 kyr ago, respectively. These later expansions may be associated with contemporaneous environmental and/or cultural changes. The timing of the L3 expansion—8–12 kyr prior to the emergence of the first non-African mtDNA lineages—together with high L3 diversity in eastern Africa, strongly supports the proposal that the human exodus from Africa and subsequent colonization of the globe was prefaced by a major expansion within Africa, perhaps driven by some form of cultural innovation.
Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae

Objectives Besifloxacin is a novel fluoroquinolone that was recently approved for topical treatment of bacterial conjunctivitis. The compound was shown to be active in vitro against a broad spectrum of bacteria, including isolates resistant to other antibacterials. Here, the bactericidal activity of besifloxacin was evaluated against the most common bacterial conjunctivitis pathogens. Methods MIC, MBC and time–kill experiments with besifloxacin and comparators were performed according to CLSI guidelines. Quinolone resistance-determining regions (QRDRs) were sequenced using standard PCR-based techniques. Results MIC and MBC data indicated that besifloxacin was the most potent fluoroquinolone tested against Staphylococcus aureus (n = 30), Staphylococcus epidermidis (n = 15) and Streptococcus pneumoniae (n = 35), while all fluoroquinolones were highly active against Haemophilus influenzae (n = 40). Besifloxacin MBC:MIC ratios were ≤4 for 97.5% of all isolates tested (n = 120). All fluoroquinolones tested, as well as tobramycin, were bactericidal, while azithromycin was bactericidal against S. pneumoniae and H. influenzae, but bacteriostatic against the staphylococci. Time–kill assays with all four species showed that besifloxacin caused ≥1000-fold killing within 2 h for 11 of 12 isolates. Only one isolate treated with moxifloxacin and three ciprofloxacin-treated isolates achieved the same level of bactericidal activity under the same conditions. Unlike the comparator fluoroquinolones, besifloxacin maintained a high potency and bactericidal activity even against strains that contained multiple mutations in the genes encoding DNA gyrase and topoisomerase IV. Conclusions Overall, besifloxacin demonstrated rapid bactericidal activity against the four major human pathogens tested here, including isolates that showed in vitro resistance to other fluoroquinolones, β-lactams, macrolides or aminoglycosides.
Stereo vision based indoor/outdoor navigation for flying robots

We introduce our new quadrotor platform for realizing autonomous navigation in unknown indoor/outdoor environments. Autonomous waypoint navigation, obstacle avoidance and flight control is implemented on-board. The system does not require a special environment, artificial markers or an external reference system. We developed a monolithic, mechanically damped perception unit which is equipped with a stereo camera pair, an Inertial Measurement Unit (IMU), two processor-and an FPGA board. Stereo images are processed on the FPGA by the Semi-Global Matching algorithm. Keyframe-based stereo odometry is fused with IMU data compensating for time delays that are induced by the vision pipeline. The system state estimate is used for control and on-board 3D mapping. An operator can set waypoints in the map, while the quadrotor autonomously plans its path avoiding obstacles. We show experiments with the quadrotor flying from inside a building to the outside and vice versa, traversing a window and a door respectively. A video of the experiments is part of this work. To the best of our knowledge, this is the first autonomously flying system with complete on-board processing that performs waypoint navigation with obstacle avoidance in geometrically unconstrained, complex indoor/outdoor environments.
Stuck in the Middle With You: The Intimate Labours of Mobility and Smuggling along Mexico’s Migrant Route

ABSTRACT This paper examines some of the intimate, embodied and affective dimensions of mobility for unauthorised Central American migrants in Mexico. While in transit, migrants become implicated within the violence of local and transnational economies of smuggling, organised crime, kidnapping and securitisation. At the same time, migrants engage intimate economies of exchange, kinship and care as they negotiate their movements and their lives. Bringing together ethnographic research and transnational feminist scholarship, this paper reconceptualises human smuggling as a form of intimate labour along migrant routes. I pay particular attention to the ways human smuggling becomes a point of closeness and intimate exchange as migrants and their smugglers strategically re-imagine the borders of kinship. While the types of social relations forged along the journey may defy traditional understandings of smuggling as inherently exploitative, I also examine how such arrangements contribute to new forms of inequality. Through a lens of intimacy, this work contributes new insights on the complex and shifting nature of Mexico’s human smuggling industry and the state policies purportedly aimed to contain it.
Deformation of spherical CR structures and the universal Picard variety

We study deformation of spherical $CR$ circle bundles over Riemann surfaces of genus > 1. There is a one to one correspondence between such deformation space and the so-called universal Picard variety. Our differential-geometric proof of the structure and dimension of the unramified universal Picard variety has its own interest, and our theory has its counterpart in the Teichmuller theory.
Real-time Pedestrian Detection in a Truck's Blind Spot Camera

In this paper we present a multi-pedestrian detection and tracking framework targeting a specific application: detecting vulnerable road users in a truck's blind spot zone. Research indicates that existing non-vision based safety solutions are not able to handle this problem completely. Therefore we aim to develop an active safety system which warns the truck driver if pedestrians are present in the truck's blind spot zone. Our system solely uses the vision input from the truck's blind spot camera to detect pedestrians. This is not a trivial task, since the application inherently requires real-time operation while at the same time attaining very high accuracy. Furthermore we need to cope with the large lens distortion and the extreme viewpoints introduced by the blind spot camera. To achieve this, we propose a fast and efficient pedestrian detection and tracking framework based on our novel perspective warping window approach. To evaluate our algorithm we recorded several realistically simulated blind spot scenarios with a genuine blind spot camera mounted on a real truck. We show that our algorithm achieves excellent accuracy results at real-time performance, using a single core CPU implementation only.
The Dynamics of Search Engine Marketing for Tourist Destinations

Search engine marketing (SEM) has become an important strategic tool for online destination marketing. Because of the dynamic relationships among travelers as information searchers, search engines, and the online tourism domain, the authors argue that a new dynamic model must be developed that captures these relationships to better inform SEM practices. The goals of this paper are twofold: (1) to synthesize research related to SEM in tourism and related fields and (2) to present a model that describes the evolving dynamics in search engine marketing. The implications of the model for tourism marketing and research are discussed.
Ethephon induced abscission in mango: physiological fruitlet responses

Fruitlet abscission of mango is typically very severe, causing considerable production losses worldwide. Consequently, a detailed physiological and molecular characterization of fruitlet abscission in mango is required to describe the onset and time-dependent course of this process. To identify the underlying key mechanisms of abscission, ethephon, an ethylene releasing substance, was applied at two concentrations (600 and 7200 ppm) during the midseason drop stage of mango. The abscission process is triggered by ethylene diffusing to the abscission zone where it binds to specific receptors and thereby activating several key physiological responses at the cellular level. The treatments reduced significantly the capacity of polar auxin transport through the pedicel at 1 day after treatment and thereafter when compared to untreated pedicels. The transcript levels of the ethylene receptor genes MiETR1 and MiERS1 were significantly upregulated in the pedicel and pericarp at 1, 2, and 3 days after the ethephon application with 7200 ppm, except for MiETR1 in the pedicel, when compared to untreated fruitlet. In contrast, ethephon applications with 600 ppm did not affect expression levels of MiETR1 in the pedicel and of MiERS1 in the pericarp; however, MiETR1 in the pericarp at day 2 and MiERS1 in the pedicel at days 2 and 3 were significantly upregulated over the controls. Moreover, two novel short versions of the MiERS1 were identified and detected more often in the pedicel of treated than untreated fruitlets at all sampling times. Sucrose concentration in the fruitlet pericarp was significantly reduced to the control at 2 days after both ethephon treatments. In conclusion, it is postulated that the ethephon-induced abscission process commences with a reduction of the polar auxin transport capacity in the pedicel, followed by an upregulation of ethylene receptors and finally a decrease of the sucrose concentration in the fruitlets.
High-performance transistors for bioelectronics through tuning of channel thickness

Transistors with tunable transconductance allow high-quality recordings of human brain rhythms. Despite recent interest in organic electrochemical transistors (OECTs), sparked by their straightforward fabrication and high performance, the fundamental mechanism behind their operation remains largely unexplored. OECTs use an electrolyte in direct contact with a polymer channel as part of their device structure. Hence, they offer facile integration with biological milieux and are currently used as amplifying transducers for bioelectronics. Ion exchange between electrolyte and channel is believed to take place in OECTs, although the extent of this process and its impact on device characteristics are still unknown. We show that the uptake of ions from an electrolyte into a film of poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) leads to a purely volumetric capacitance of 39 F/cm3. This results in a dependence of the transconductance on channel thickness, a new degree of freedom that we exploit to demonstrate high-quality recordings of human brain rhythms. Our results bring to the forefront a transistor class in which performance can be tuned independently of device footprint and provide guidelines for the design of materials that will lead to state-of-the-art transistor performance.