Miracle-dz/UniFAR-FTUs huggingface dataset:
Muscle-Bound Primordial Stem Cells Give Rise to Myofiber-Associated Myogenic and Non-Myogenic Progenitors

Myofiber cultures give rise to myogenic as well as to non-myogenic cells. Whether these myofiber-associated non-myogenic cells develop from resident stem cells that possess mesenchymal plasticity or from other stem cells such as mesenchymal stem cells (MSCs) remain unsolved. To address this question, we applied a method for reconstructing cell lineage trees from somatic mutations to MSCs and myogenic and non-myogenic cells from individual myofibers that were cultured at clonal density. Our analyses show that (i) in addition to myogenic progenitors, myofibers also harbor non-myogenic progenitors of a distinct, yet close, lineage; (ii) myofiber-associated non-myogenic and myogenic cells share the same muscle-bound primordial stem cells of a lineage distinct from bone marrow MSCs; (iii) these muscle-bound primordial stem-cells first part to individual muscles and then differentiate into myogenic and non-myogenic stem cells.
Oral vasopressin receptor antagonist tolvaptan in right heart failure due to pulmonary hypertension

During the past decade, the prognosis of patients with pulmonary hypertension (PH) has improved due to the development of pulmonary arterial vasodilators [1]. Yet, treatment for right-sided heart failure (RHF) associated with PH has not improved, despite being the most important prognostic factor for chronic RHF [2, 3]. Existing treatment strategies for RHF associated with PH are restricted to administration of loop diuretics and inotropes [4]; however, administration of high doses of loop diuretics may worsen the outcome of chronic heart failure [5, 6]. In recent years, tolvaptan, an oral, nonpeptide, selective vasopressin V2-receptor antagonist, has been developed for the treatment of hyponatraemia [7], autosomal dominant polycystic kidney disease [8] and heart failure. Used in addition to standard therapy that includes diuretics, tolvaptan improves many signs and symptoms of heart failure without serious adverse events [9]. However, there is no report describing the effect of tolvaptan on RHF, independent of left-sided heart disease. Vasopressin receptor antagonist tolvaptan achieved furosemide reductions and right heart failure improvements in PH http://ow.ly/Lopej
Teacherâ€™s Perception of Literacy Program: Its Implication to Their Attitudes and Actions

Teachers as the tip of lance play important roles in the success of the implementation of school literacy program such as possessing positive perception of literacy practices. Recognizing the important roles of teachers in the implementation of literacy program in the schools, this study aims to investigate the teachers‟ perception toward the implementation of literacy program at a Junior High School in Surabaya. This study is designed as an interpretative qualitative approach. Primary data were obtained through open interviews and observations and supplementary data source included student journal. The data findings showed that teachers have positive perceptions on literacy program. They argue that school literacy program potentially enables to build up the students‟ good habits. Through the habituation of a thirty-minute reading before the class, it can raise the students‟ awareness on literacy reading and writing. Moreover, the school literacy program benefits the students‟ competency in understanding long texts and can help them to be more critical and creative. In addition, instead of students who take advantageous from the literacy program, teachers are also equally benefited from exposure to daily literacy practices within the school. The teachers tend to follow the rhymes of the literacy practices which are marked by reading and writing activities. In this sense, literacy practices facilitate teachers to develop their practical writing abilities and increase their awareness to be the role model in the classrooms particularly in the literacy practices. This study emphasizes that literacy practices can be double blades, on one side it is beneficial for the students and on another side it is advantageous for the teachers.
Compile-time analysis on programs with dynamic pointer-linked data structures

This paper studies static analysis on programs that create and traverse dynamic pointer-linked data structures. It introduces a new type of auxiliary structures, called link graphs, to depict the alias information of pointers and connection relationships of dynamic pointer-linked data structures. The link graphs can be used by compilers to detect side effects, to identify the patterns of traversal, and to gather the DEF-USE information of dynamic pointer-linked data structures. The results of the above compile-time analysis are essential for parallelization and optimizations on communication and synchronization overheads. Algorithms that perform compile-time analysis on side effects and DEF-USE information using link graphs will be proposed.
A New Look at Stratospheric Sudden Warmings. Part III: Polar Vortex Evolution and Vertical Structure

The evolution of the Arctic polar vortex during observed major midwinter stratospheric sudden warmings (SSWs) is investigated for the period 1957‐2002, using 40-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40) Ertel’s potential vorticity (PV) and temperature fields. Timelag composites of vertically weighted PV, calculated relative to the SSW onset time, are derived for both vortex-displacement SSWs and vortex-splitting SSWs, by averaging over the 15 recorded displacement and 13 splitting events. The evolving vertical structure of the polar vortex during a typical SSW of each type is clearly illustrated by plotting an isosurface of the composite PV field, and is shown to be very close to that observed during representative individual events. Results are verified by comparison with an elliptical diagnostic vortex moment technique. For both types of SSW, little variation is found between individual events in the orientation of the developing vortex relative to the underlying topography; that is, the location of the vortex during SSWs of each type is largely fixed in relation to the earth’s surface. During each type of SSW, the vortex is found to have a distinctive vertical structure. Vortex-splitting events are typically barotropic, with the vortex split occurring near simultaneously over a large altitude range (20‐40 km). In the majority of cases, of the two daughter vortices formed, it is the ‘‘Siberian’’ vortex that dominates over its ‘‘Canadian’’ counterpart. In contrast, displacement events are characterized by a very clear baroclinic structure; the vortex tilts significantly westward with height, so that the top and bottom of the vortex are separated by nearly 1808 longitude before the upper vortex is sheared away and destroyed.
Modeling Spatial Dimensions of Housing Prices in Milwaukee, WI

In this study we investigate spatial dimensions of housing-market dynamics in the City of Milwaukee by modeling the determinants of housing prices. From the 2003 Master Property data file of the city, two sets of owner-occupied single-family houses were randomly selected (one to construct the models, and the other to rest the models). Besides conventional housing attributes, remote-sensing information, in particular the fractions of soil and impervious surface representing degraded neighborhood environment conditions, is added to improve the model. Spatial regression and geographically weighted regression approaches are employed to examine spatial dependence and heterogeneity. Results reveal that these spatial models tend to perform better, especially in terms of model performance and predictive accuracy, than the ordinary least squares estimates.
Evaluation of a Smartphone Decision-Support Tool for Diarrheal Disease Management in a Resource-Limited Setting

The emergence of mobile technology offers new opportunities to improve clinical guideline adherence in resource-limited settings. We conducted a clinical pilot study in rural Bangladesh to evaluate the impact of a smartphone adaptation of the World Health Organization (WHO) diarrheal disease management guidelines, including a modality for age-based weight estimation. Software development was guided by end-user input and evaluated in a resource-limited district and sub-district hospital during the fall 2015 cholera season; both hospitals lacked scales which necessitated weight estimation. The study consisted of a 6 week pre-intervention and 6 week intervention period with a 10-day post-discharge follow-up. Standard of care was maintained throughout the study with the exception that admitting clinicians used the tool during the intervention. Inclusion criteria were patients two months of age and older with uncomplicated diarrheal disease. The primary outcome was adherence to guidelines for prescriptions of intravenous (IV) fluids, antibiotics and zinc. A total of 841 patients were enrolled (325 pre-intervention; 516 intervention). During the intervention, the proportion of prescriptions for IV fluids decreased at the district and sub-district hospitals (both p < 0.001) with risk ratios (RRs) of 0.5 and 0.2, respectively. However, when IV fluids were prescribed, the volume better adhered to recommendations. The proportion of prescriptions for the recommended antibiotic azithromycin increased (p < 0.001 district; p = 0.035 sub-district) with RRs of 6.9 (district) and 1.6 (sub-district) while prescriptions for other antibiotics decreased; zinc adherence increased. Limitations included an absence of a concurrent control group and no independent dehydration assessment during the pre-intervention. Despite limitations, opportunities were identified to improve clinical care, including better assessment, weight estimation, and fluid/ antibiotic selection. These findings demonstrate that a smartphone-based tool can improve guideline adherence. This study should serve as a catalyst for a randomized controlled trial to expand on the findings and address limitations.
The effect of problem-based learning and project-based learning on the achievement motivation

This study aimed to reveal: (1) the effect of PBL on the achievement motivation; (2) the effect of PjBL on the achievement motivation; and (3) differences of achievement motivation between the group taught using PBL and the group taught using PjBL. This study was a quasi experiment with the nonequivalent commparison group design. The population was grade V students of SD Negeri Lempuyangwangi in academic year 2016/2017. The data analysis used t-test and Univariate Analysis of Variance at the significant levelof 5%. The result are as follows: (1) PBL improved positively and significantly on theachievement motivation; (2) PjBL improved positively and significantly on theachievement motivation; and (3) there is a significant difference on theachievement motivation between the group taught using PBL and that taught using PjBL.
PENGARUH KOMPETENSI TERHADAP KESIAPAN MAHASISWA JURUSAN AKUNTANSI DALAM MENGHADAPI MASYARAKAT EKONOMI ASEAN

The objective of this study is to examine and analyze the influences of ethical competency, knowledge competency, capability competency, relationship competency and analysis competency on the readiness of accounting student of Bengkulu University for ASEAN Economic Community. This research is empirical research with quantitative approach which involves the use of statistical analysis. This research used the primary data. The tool used in this research is multiple regression analysis with SPSS software version 18. The results of this research showed a positive relationship between the accounting students knowledge, Capability and Analysis competencies and the readiness of accounting student of Bengkulu University for ASEAN Economic Community. But, the results of this research didn’t fi nd any signi fi cant posit ive relati on ship betw een the accounti ng students’ Ethical and Relationship competencies and the readiness of accounting student of Bengkulu University for ASEAN Economic Community.
Deploying monotrans widgets in the wild

In this paper, we report our experience deploying the MonoTrans Widgets system in a public setting. Our work follows a line of crowd-sourced monolingual translation systems, and it is the first attempt to deploy such a system "in the wild". The results are promising, but we also found out that simultaneously drawing from multiple crowds with different expertise and sizes poses unique problems in the design of such crowd-sourcing systems.
Implementing a new student evaluation of teaching system using the Kotter change model

ABSTRACT Kotter’s (1996. Leading Change. Boston, MA: Harvard Business School Press) model is one of the most frequently cited guides for implementing planned organizational change. While this model is widely used across many industries and contexts, including higher education, there are few research studies and cases that provide in-depth information on the applicability and potential of this model to inform successful change initiatives. In this paper, we describe how we used Kotter's model as a guide when embarking on a multi-year effort to change our university's system for student evaluation of teaching. This change involved a shift in both instrument and technology and involved dozens of stakeholders in a complex and changing environment. Our case provides an example of how Kotter's model can be helpful in implementing change on a variety of initiatives within institutions of higher education. Limitations and implications for both research and practice are discussed.
Title : Contrast adaptation in a non-adapting LGN model

Sensory neurons appear to adapt their gain to match the variance of signals along the dimension they encode, a property we shall call “contrast normalization”. Contrast normalization has been the subject of extensive physiological and theoretical study. We previously found that neurons in the lateral geniculate nucleus (LGN) exhibit contrast normalization in their responses to full-field flickering white-noise stimuli, and that neurons with the strongest contrast normalization best preserved information transmission across a range of contrasts. We have also shown that both of these properties could be reproduced by non-adapting model cells. Here we present a detailed comparison of this non-adapting model to physiological data from the LGN. First, the model cells recapitulated other contrast dependencies of LGN responses: decreasing stimulus contrast resulted in an increase in spike-timing jitter and spikenumber variability. Second, we find that the extent of contrast normalization in this model depends on model parameters related to refractoriness and to noise. Third, we show that the model cells exhibit rapid, transient changes in firing rate just after changes in contrast, and that this is sufficient to produce the transient changes in information transmission that have been reported in other neurons. It is known that intrinsic properties of neurons change upon contrast adaptation. Nevertheless the model demonstrates that the spiking nonlinearity of neurons can produce many of the temporal aspects of contrast gain control, including normalization to input variance and transient effects of contrast change.
Texture classification using discriminant wavelet packet subbands

This paper addresses the issue of selecting features from a given wavelet packet subband decomposition that are most useful for texture classification in an image. A functional measure based on Kullback-Leibler distance is proposed as a way to select most discriminant subbands. Experimental results show a superior performance in terms of classification error rates.
Transcription Initiation and Termination on Leishmania major Chromosome 3

ABSTRACT Genome projects involving Leishmania and other trypanosomatids have revealed that most genes in these organisms are organized into large clusters of genes on the same DNA strand. We have previously shown that transcription of the entire Leishmania major Friedlin (LmjF) chromosome 1 (chr1) initiates bidirectionally between two divergent gene clusters. Here, we analyze transcription of LmjF chr3, which contains two convergent clusters of 67 and 30 genes, separated by a tRNA gene, with a single divergent protein-coding gene located close to the “left” telomere. Nuclear run-on analyses indicate that specific transcription of chr3 initiates bidirectionally between the single subtelomeric gene and the adjacent 67-gene cluster, close to the “right” telomere upstream of the 30-gene cluster, and upstream of the tRNA gene. Transcription on both strands terminates within the tRNA-gene region. Transient-transfection studies support the role of the tRNA-gene region as a transcription terminator for RNA polymerase II (Pol II) and Pol III, and also for Pol I.
Microwave Sensing of Acoustically Induced Local Harmonic Motion: Experimental and Simulation Studies on Breast Tumor Detection

Sensing acoustically induced local harmonic motion using a microwave transceiver system may provide useful information for detecting nonpalpable tumors in dense breast tissue. For this purpose, we propose the harmonic motion microwave Doppler imaging method, in which the first harmonic of the phase modulated signal due to local harmonic motion is sensed. This signal is related to the dielectric, elastic, and acoustic properties of the vibrating region. The purpose of this paper is twofold: 1) to demonstrate the concept of this method with experiments using phantom materials mimicking the elastic and electrical properties of the breast tissue and 2) to investigate the effect of fibroglandular region size and vibration frequency on the received signal, using numerical simulations. A breast phantom with a tumor phantom inclusion (5-mm diameter and 7-mm height) inside fibroglandular region is constructed for the experimental study. The response due to a focused ultrasound probe is linearly scanned at 30-mm depth from the phantom surface, and the Doppler signal level is tracked using a spectrum analyzer. It is shown that the tumor phantom is resolvable inside the surrounding fibroglandular region with about a 3-5-dB decrease in the signal level. The simulations, using the finite-difference time-domain method, show that the received signal level depends on the relative size of the fibroglandular region with respect to the vibrating region size. Further experimental and numerical studies are needed to investigate the feasibility of this method and to optimize the imaging system design.
Children's Task Engagement During Challenging Puzzle Tasks

Abstract:We examined children's task engagement during a challenging puzzle task in the presence of their primary caregivers by using a representative sample of rural children from six high-poverty counties across two states. Weighted longitudinal confirmatory factor analysis and structural equation modeling were used to identify a task engagement factor indicated by child positive mood, persistence, enthusiasm, and compliance at both 24 and 35 months. Child attention and maternal responsiveness were significantly related to child task engagement at 24 and 35 months controlling for demographic factors. Additionally, a challenging behavior factor in children's task-oriented behaviors was found as indicated by child negative mood, aggression and noncompliance. This factor was predicted by low maternal acceptance of child behaviors. Theoretical and practical implications are discussed.
The Effects of a Mobile Assisted Vocabulary Learning Application on Vocabulary Learning

Son yillarda yasanan gelismeler teknolojinin dil ogrenme surecinde kullanilmasini kacinilmaz hale getirmistir. Buna bagli olarak mobil destekli dil ogrenimi son yillarda onem kazanmistir. Mobil destekli dil ogreniminin yani sira, dil ogrenme stillerinin dil ogrenme surecini ve mobil destekli dil ogrenimi uygulamalarinin kullanimini etkiledigi reddedilemez bir gercektir. Bahsedilen bu bilgiler isiginda tasarlanan bu calismanin amaci, ogrencilerin arastirmaci tarafindan gelistirilen mobil destekli bir kelime ogrenimi uygulamasinin (VocaStyle) ve dil ogrenme stillerinin ogrenme sureclerine etkisi ile ilgili goruslerini belirlemektir. Arastirma, nitel arastirma desenlerinden durum calismasi modelinde tasarlanmistir. Arastirma verileri yari yapilandirilmis gorusme formu ile toplanmistir. Arastirma kapsaminda calisma grubunu olusturan 10 katilimci ile gorusmeler yapilmistir. Bahsedilen 10 katilimci 5’i isitsel, 5’i gorsel ogreniciler olacak sekilde belirlenmistir. Veri analizi surecinde tematik icerik analizi yontemi kullanilmistir. Arastirma bulgulari, ogrencilerin mobil destekli kelime uygulamasini yararli, etkili ve guduleyici bulduklarini ortaya cikarmistir. Arastirma kapsaminda elde edilen baska bir bulgu ise ogrencilerin aciklayici eklere iliskin goruslerinin ogrenme stillerine gore degistigidir.
Impaired Motility of Neonatal PMN Leukocytes: Relationship to Abnormalities of Cell Orientation and Assembly of Microtubules in Chemotactic Gradients

To allow a further understanding of the pathogenesis of impaired stimulated locomotion by polymorphonuclear leukocytes (PMNs) in human neonates, we studied cellular orientation by neonatal PMNs in response to well‐defined chemotactic gradients (Zigmond orientation chambers) and characterized the cytoplasmic microtubule (MT) complex of neonatal PMNs during cell orientation and movement. PMN suspensions obtained from 52 neonates demonstrated a diminished capacity to undergo orientation at all time intervals after exposure to gradients of N‐formyl‐methionyl‐leucyl phenylalanine (f‐Met‐Leu‐Phe) or C5a. Among responding (orienting) neonatal PMNs observed, only 70% (f‐Met‐Leu‐Phe) or 59% (C5a) oriented accurately (toward chemotactic gradients) as compared to values of 96% (f‐Met‐Leu‐Phe) or 92% (C5a) for adult controls. Furthermore, neonatal PMNs failed to alter their direction of orientation/migration when chemotactic gradients were reversed. Similar abnormalities were observed when 10‐fold gradients of f‐Met‐Leu‐Phe were employed over a concentration range between 10−7 and 10−11 M. Employing tubulin immunofluorescence, the cytoplasmic MT complex of‐neonatal PMNs was assessed prior to and after cell exposure to uniform concentrations or gradients of chemotactic factors (CFs). MT assembly by neonatal PMNs studied under these experimental conditions was significantly diminished. Neonatal cell suspensions demonstrated 26 ± 5 (f‐Met‐Leu‐Phe) or 27 ± 6 (C5a) MT/cell as compared to respective values of 36 ± 6 or 35 ± 5 for adult suspensions (P <.001). MT lengths of neonatal PMNs increased from 6.7 ± 1 µm (PBS) to 7.5 ± 1 µm (f‐Met‐Leu‐Phe) or 7.3 ± 1 µm (C5a) as © 1984 Alan R. Liss, Inc. Anderson et al compared to values of 6.5 ± 1 µm (PBS), 11.1 ± 1 µm (f‐Met‐Leu‐Phe), and 10.9 ± 1 µm (C5a) for adult PMNs exposed to gradients or uniform concentrations of CFs (P <.01 for both f‐Met‐Leu‐Phe and C5a). Thus, the polymerized tubulin mass product of chemotactically stimulated neonatal PMNs (202 µm) was significantly (P <.001) diminished as compared to adult PMNs (360 µm). As shown by a [3H]colchicine binding assay, impaired MT assembly could not be attributed to diminished cytoplasmic tubulin content of neonatal PMNs, which was comparable to adult PMNs.