Miracle-dz/UniFAR-FTUs huggingface dataset:
Medication prescribing errors in the intensive care unit of Jimma University Specialized Hospital, Southwest Ethiopia

Background A number of studies indicated that prescribing errors in the intensive care unit (ICU) are frequent and lead to patient morbidity and mortality, increased length of stay, and substantial extra costs. In Ethiopia, the prevalence of medication prescribing errors in the ICU has not previously been studied. Objective To assess medication prescribing errors in the ICU of Jimma University Specialized Hospital (JUSH), Southwest Ethiopia. Methods A cross-sectional study was conducted in the ICU of Jimma University Specialized Hospital from February 7 to April 15, 2011. All medication-prescribing interventions by physicians during the study period were included in the study. Data regarding prescribing interventions were collected from patient cards and medication charts. Prescribing errors were determined by comparing prescribed drugs with standard treatment guidelines, textbooks, handbooks, and software. Descriptive statistics were generated to meet the study objective. Results The prevalence of medication prescribing errors in the ICU of Jimma University Specialized Hospital was 209/398 (52.5%). Common prescribing errors were using the wrong combinations of drugs (25.7%), wrong frequency (15.5%), and wrong dose (15.1%). Errors associated with antibiotics represented a major part of the medication prescribing errors (32.5%). Conclusion Medication errors at the prescribing phase were highly prevalent in the ICU of Jimma University Specialized Hospital. Health care providers need to establish a system which can support the prescribing physicians to ensure appropriate medication prescribing practices.
Detection of Prostate Cancer and Predicting Progression

Carcinoma of the prostate is the second leading cause of male cancer-related death in the United States. Better indicators of prostate cancer presence and progression are needed to avoid unnecessary treatment, predict disease course, and develop more effective therapy. Numerous molecular markers have been described in human serum, urine, seminal fluid, and histological specimens that exhibit varying capacities to detect prostate cancer and predict disease course. However, to date, few of these markers have been adequately validated for clinical use. The purpose of this review is to examine the current status of these markers in prostate cancer and to assess the diagnostic potential for future markers from identified genes and molecules that display loss, mutation, or alteration in expression between tumor and normal prostate tissues. In this review we cite 91 molecular markers that display some level of correlation with prostate cancer presence, disease progression, cancer recurrence, prediction of response to therapy, and/or disease-free survival. We suggest criteria to consider when selecting a marker for further development as a clinical tool and discuss five examples of markers (chromogranin A, glutathione S-transferase π 1, prostate stem cell antigen, prostate-specific membrane antigen, and telomerase reverse transcriptase) that fulfill some of these criteria. Finally, we discuss how to conduct evaluations of candidate prostate cancer markers and some of the issues involved in the validation process.
Export-led growth in Bangladesh: a time series analysis

This article examines time series evidence to investigate the link between exports and economic growth in Bangladesh. Using quarterly data for a period from 1976 to 2003 the article finds that industrial production and exports are cointegrated. The results of an error correction model (ECM) suggest that there is a long-run unidirectional causality from exports to growth in Bangladesh.
Ninein is released from the centrosome and moves bi-directionally along microtubules

Cell-to-cell contact and polarisation of epithelial cells involve a major reorganisation of the microtubules and centrosomal components. The radial microtubule organisation is lost and an apico-basal array develops that is no longer anchored at the centrosome. This involves not only the relocation of microtubules but also of centrosomal anchoring proteins to apical non-centrosomal sites. The relocation of microtubule minus-end-anchoring proteins such as ninein to the apical sites is likely to be essential for the assembly and stabilisation of the apico-basal arrays in polarised epithelial cells. In this study, we establish that ninein is highly dynamic and that, in epithelial cells, it is present not only at the centrosome but also in the cytoplasm as distinct speckles. Live-cell imaging reveals that GFP-ninein speckles are released from the centrosome and move in a microtubule-dependent manner within the cytoplasm and thus establishes that epithelial cells possess the mechanical means for relocation of ninein to non-centrosomal anchoring sites. We also provide evidence for the deployment of ninein speckles to apical anchoring sites during epithelial differentiation in both an in situ tissue and an in vitro culture system. In addition, the findings suggest that the non-centrosomal microtubule anchoring sites associate with adherens junctions in polarised epithelial cells.
Anaesthesia with sevoflurane in pigeons: minimal anaesthetic concentration (MAC) determination and investigation of cardiorespiratory variables at 1 MAC

The objective of the study was to determine the minimal anaesthetic concentration (MAC) of sevoflurane (SEVO) in pigeons and investigate the effects of 1 MAC SEVO anaesthesia on cardiovascular and respiratory variables compared with the awake state. This is a prospective, experimental study. Animals were seven healthy adult pigeons. After acclimatisation to handling, heart rate (HR), heart rhythm, respiratory rate (fR), end-expired carbon dioxide tension (PE′CO2), inspired CO2 tension, indirect systolic arterial blood pressure (SAP) and cloacal temperature were measured to determine baseline, ‘awake’ values. Pigeons were then anaesthetised with SEVO and MAC was determined by the ‘bracketing’ method. The same variables were monitored during a 40 minute period at 1.0 MAC SEVO for each bird. Mean MAC was 3.0±0.6 per cent for SEVO. During maintenance of anaesthesia at 1.0 MAC, SAP decreased significantly (P<0.001) without any significant change in HR. Although PE′CO2 increased significantly (P=0.001) despite an increase in fR, awake PE′CO2 values were unexpectedly low. Sinus arrhythmias were detected in two birds under SEVO anaesthesia. The times to tracheal intubation and to recovery were 2.5±0.7 and 6.4±1.7 minutes, respectively. Recovery was rapid and uneventful in all birds. In conclusion, SEVO is suitable for anaesthesia in pigeons.
Immune response to virus-infection-associated (VIA) antigen in cattle repeatedly vaccinated with foot-and-mouth disease virus inactivated by formalin or acetylethyleneimine

SUMMARY The results of experiments to investigate antibody to ‘virus infection associated’ (VIA) antigen in cattle repeatedly vaccinated with formalin- or acetylethyleneimine- (AEI) inactivated foot-and-mouth disease (FMD) vaccines under laboratory conditions are reported. Results are also presented from some vaccinated animals subsequently exposed to FMD infection. Antibody against VIA was not detected before and after the first vaccination with formalin or AEI-inactivated vaccine but did develop in all animals after the second formalin vaccination and persisted throughout the experiment. After the second AEI vaccination, 4 of 12 animals developed antibody which persisted for at least 37 days. This transient response in some cattle was repeated after successive vaccinations but, in general, more animals responded as the number of vaccinations increased. After exposure to infection, a transient VIA antibody response was occasionally observed in immune AEI-vaccinated animals. Some immune repeatedly AEI-vaccinated cattle did not develop detectable VIA antibody after challenge despite the persistence of virus in oesophageal–pharyngeal (O/P) fluid. The presence of antibody to VIA antigen is not conclusive proof that vaccinated animals have been exposed to infection and field data must be interpreted with caution.
Relaxation dynamics and aging in structural glasses

We present a study of the atomic dynamics in a Mg65Cu25Y10 metallic glass former both in the deep glassy state and in the supercooled liquid phase. Our results show that the glass transition is accompanied by a dynamical crossover between a faster than exponential shape of the intermediate scattering function in the glassy state and a slower than exponential shape in the supercooled liquid. While the crossover temperature is independent on the previous thermal history, both the relaxation rate and the shape of the relaxation process depend on the followed thermal path. Moreover, the temperature dependence of the the structural relaxation time displays a strong departure from the Arrhenius-like behavior of the corresponding supercooled liquid phase, and can be well described in the Narayanaswamy-Moynihan framework with a large non-linearity parameter.
Combinatorial Approach to Multiple Contact Faults Coverage in Programmable Logic Arrays

The increasing number of applications of programmable logic arrays (PLA's) has evoked the development of test generation methods for these circuits. There are known methods for complete single contact fault detection test set generation. These test sets fail to detect all multiple faults in a PLA due to the phenomenon of masking. In this correspondence, we present a method to quantitively predict the multiple fault coverage capability of a single fault detection test set in a PLA. The method enables us to determine the coverage ratio, which is defined as the ratio of the number of multiple contact faults detected by a single fault test Tc to the total number of all multiple faults. It is shown that the multiple fault coverage ratio of Tc drops with an increasing size of faults, and most unexpectedly, the ratio increases with an increasing number of rows. The number of crosspoints in one product line has very little influence on the ratio.
Contact-Free Measurement of Cardiac Pulse Based on the Analysis of Thermal Imagery

We have developed a novel method to measure human cardiac pulse at a distance. It is based on the information contained in the thermal signal emitted from major superficial vessels. This signal is acquired through a highly sensitive thermal imaging system. Temperature on the vessel is modulated by pulsative blood flow. To compute the frequency of modulation (pulse), we extract a line-based region along the vessel. Then, we apply fast Fourier transform (FFT) to individual points along this line of interest to capitalize on the pulse's thermal propagation effect. Finally, we use an adaptive estimation function on the average FFT outcome to quantify the pulse. We have carried out experiments on a data set of 34 subjects and compared the pulse computed from our thermal signal analysis method to concomitant ground-truth measurements obtained through a standard contact sensor (piezo-electric transducer). The performance of the new method ranges from 88.52% to 90.33% depending on the clarity of the vessel's thermal imprint. To the best of our knowledge, it is the first time that cardiac pulse has been measured several feet away from a subject with passive means.
Send Orders of Reprints at Reprints@benthamscience.org the Lymphocyte Transformation Test for Borrelia Detects Active Lyme Borreliosis and Verifies Effective Antibiotic Treatment

Borrelia-specific antibodies are not detectable until several weeks after infection and even if they are present, they are no proof of an active infection. Since the sensitivity of culture and PCR for the diagnosis or exclusion of borrelio-sis is too low, a method is required that detects an active Borrelia infection as early as possible. For this purpose, a lym-phocyte transformation test (LTT) using lysate antigens of Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii and recombinant OspC was developed and validated through investigations of seronegative and seropositive healthy individuals as well as of seropositive patients with clinically manifested borreliosis. The sensitivity of the LTT in clinical borreliosis before antibiotic treatment was determined as 89,4% while the specificity was 98,7%. In 1480 patients with clinically suspected borreliosis, results from serology and LTT were comparable in 79.8% of cases. 18% were sero-logically positive and LTT-negative. These were mainly patients with borreliosis after antibiotic therapy. 2.2% showed a negative serology and a positive LTT result. Half of them had an early erythema migrans. Following antibiotic treatment, the LTT became negative or borderline in patients with early manifestations of borreliosis, whereas in patients with late symptoms, it showed a regression while still remaining positive. Therefore, we propose the follow-up monitoring of disseminated Borrelia infections as the main indication for the Borrelia-LTT. INTRODUCTION Lyme borreliosis is the most common disease transmitted by tick bite. Lyme borreliosis first manifests locally on the skin at the site of the tick bite and then systemically, possibly affecting one or more organs such as the skin, joints, muscles , sense organs, nervous system and heart. In the latter case, early (stage I and II) and late (stage III) manifestations can be distinguished (1). Lyme borreliosis should be diagnosed by history and clinical symptoms. If the clinical symptoms are clear, laboratory diagnostics are of secondary importance only. The difficulty is, however, that the tick bite often goes unnoticed and the erythema migrans does not necessarily occur or is not noticed. In these cases, the requirement for early antibiotic treatment of borreliosis to prevent the complications of systemic dissemination of the pathogen, particularly of late borreliosis, cannot be met.
Heterogeneous particle swarm optimizers

Particle swarm optimization (PSO) is a swarm intelligence technique originally inspired by models of flocking and of social influence that assumed homogeneous individuals. During its evolution to become a practical optimization tool, some heterogeneous variants have been proposed. However, heterogeneity in PSO algorithms has never been explicitly studied and some of its potential effects have therefore been overlooked. In this paper, we identify some of the most relevant types of heterogeneity that can be ascribed to particle swarms. A number of particle swarms are classified according to the type of heterogeneity they exhibit, which allows us to identify some gaps in current knowledge about heterogeneity in PSO algorithms. Motivated by these observations, we carry out an experimental study of two heterogeneous particle swarms each of which is composed of two kinds of particles. Directions for future developments on heterogeneous particle swarms are outlined.
Face Translation between Images and Videos using Identity-aware CycleGAN

This paper presents a new problem of unpaired face translation between images and videos, which can be applied to facial video prediction and enhancement. In this problem there exist two major technical challenges: 1) designing a robust translation model between static images and dynamic videos, and 2) preserving facial identity during image-video translation. To address such two problems, we generalize the state-of-the-art image-to-image translation network (Cycle-Consistent Adversarial Networks) to the image-to-video/video-to-image translation context by exploiting a image-video translation model and an identity preservation model. In particular, we apply the state-of-the-art Wasserstein GAN technique to the setting of image-video translation for better convergence, and we meanwhile introduce a face verificator to ensure the identity. Experiments on standard image/video face datasets demonstrate the effectiveness of the proposed model in both terms of qualitative and quantitative evaluations.
Management of anorectal foreign bodies: a cause of obscure anal pain.

BACKGROUND Few patients with anorectal foreign bodies will freely admit to transanal introduction. The results of long-term follow-up in these patients have been sparse. METHODS Data from April 1989 to April 1997 were extracted from a prospective computerized database. The clinical features and the results of a departmental management protocol for anorectal foreign bodies were analysed. In addition, long-term outcomes were obtained by telephone interview. RESULTS Thirty patients (25 men, 5 women) with a mean age of 46 (range 16-72) years) were treated for this condition. While 10 patients (33.3%) admitted to transanal insertion, the remaining 20 (66.7%) complained of anal pain. Among the latter, the foreign body was subsequently found on routine digital rectal examination in nine patients (45%), on X-ray in nine (45%) and it was passed out unexpectedly after fleet enema in two (10%). Factors which raised suspicion for X-rays included atypical gender behaviour, lax anal sphincters and bloody or mucoid rectal discharge. Transanal recovery was successful with sedation in 12 (40%), general anaesthesia in 13 (43.3%), and laparotomy was needed in three (10%; which included one perforated bowel at presentation). There were two complications (6.7%; one minor rectal abrasion and one bronchopneumonia). There was no long-term faecal incontinence or re-impaction of foreign bodies at 63 (range 8-96) months of follow-up. CONCLUSIONS Foreign bodies should be suspected in patients with obscure anal pain. Judicious transanal extraction under sedation or general anaesthesia was usually successful with minimal short- and long-term complications.
Charge Screening by Internal pH and Polyvalent Cations as a Mechanism for Activation, Inhibition, and Rundown of TRPM7/MIC Channels

The Mg2+-inhibited cation (MIC) current, believed to represent activity of TRPM7 channels, is found in lymphocytes and mast cells, cardiac and smooth muscle, and several other eukaryotic cell types. MIC current is activated during whole-cell dialysis with divalent-free internal solutions. Millimolar concentrations of intracellular Mg2+ (or other divalent metal cations) inhibit the channels in a voltage-independent manner. The nature of divalent inhibition and the mechanism of channel activation in an intact cell remain unknown. We show that the polyamines (spermine, spermidine, and putrescine) inhibit the MIC current, also in a voltage-independent manner, with a potency that parallels the number of charges. Neomycin and poly-lysine also potently inhibited MIC current in the absence of Mg2+. These same positively charged ions inhibited IRK1 current in parallel with MIC current, suggesting that they probably act by screening the head group phosphates on PIP2 and other membrane phospholipids. In agreement with this hypothesis, internal protons also inhibited MIC current. By contrast, tetramethylammonium, tetraethylammonium, and hexamethonium produced voltage-dependent block but no inhibition. We show that inhibition by internal polyvalent cations can be relieved by alkalinizing the cytosol using externally applied ammonium or by increasing pH in inside-out patches. Furthermore, in perforated-patch and cell-attached recordings, when intracellular Mg2+ is not depleted, endogenous MIC or recombinant TRPM7 currents are activated by cytosolic alkalinization and inhibited by acidification; and they can be reactivated by PIP2 following rundown in inside-out patches. We propose that MIC (TRPM7) channels are regulated by a charge screening mechanism and may function as sensors of intracellular pH.
Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts

Sphingolipids play important roles in plasma membrane structure and cell signaling. However, their lateral distribution in the plasma membrane is poorly understood. Here we quantitatively analyzed the sphingolipid organization on the entire dorsal surface of intact cells by mapping the distribution of 15N-enriched ions from metabolically labeled 15N-sphingolipids in the plasma membrane, using high-resolution imaging mass spectrometry. Many types of control experiments (internal, positive, negative, and fixation temperature), along with parallel experiments involving the imaging of fluorescent sphingolipids—both in living cells and during fixation of living cells—exclude potential artifacts. Micrometer-scale sphingolipid patches consisting of numerous 15N-sphingolipid microdomains with mean diameters of ∼200 nm are always present in the plasma membrane. Depletion of 30% of the cellular cholesterol did not eliminate the sphingolipid domains, but did reduce their abundance and long-range organization in the plasma membrane. In contrast, disruption of the cytoskeleton eliminated the sphingolipid domains. These results indicate that these sphingolipid assemblages are not lipid rafts and are instead a distinctly different type of sphingolipid-enriched plasma membrane domain that depends upon cortical actin.
Cooling Schedules for Optimal Annealing

A Monte Carlo optimization technique called “simulated annealing” is a descent algorithm modified by random ascent moves in order to escape local minima which are not global minima. The level of randomization is determined by a control parameter T, called temperature, which tends to zero according to a deterministic “cooling schedule. ” We give a simple necessary and sufficient condition on the cooling schedule for the algorithm state to converge in probability to the set of globally minimum cost states. In the special case that the cooling schedule has parametric form Tt = c/log1 + t, the condition for convergence is that c be greater than or equal to the depth, suitably defined, of the deepest local minimum which is not a global minimum state.
The Estimation of the Current-Density Distribution in a Moving Arc Root Using the ART Algorithm

This paper mainly contributes to the estimation of 2-D current-density distribution in a moving arc root. For this purpose, the multiple-split-cathode-with-different-slit-angle method is used to perform measurements of the linear current distribution of the arc root in seven different directions. On the basis of the measurement results, a large system of linear algebraic equations is treated with the algebraic-reconstruction-technique algorithm to obtain the 2-D current density. The calculation results indicate that the transverse profile of current density in a moving arc root can be characterized by a high-current core with two low-current hysteretic wings and that the maximum current density tends to the fore part of it.