Miracle-dz/UniFAR-FTUs huggingface dataset:
PULMONARY STENOSIS WITH NORMAL AORTIC ROOT

one; typical giant a waves were seen in the neck in every instance; the cardiac impulse was tapping in all but one, in which a strong right ventricular heave extended from the sternal border to the apex beat; a powerful parastemal lift was felt in all cases, but no pulsation could be felt over the pulmonary artery itself; a localized systolic thrill was easily felt in five cases, and was always maximal in the second left intercostal space high up over the pulmonary artery; the two exceptions had a localized systolic murmur; the second heart sound was invariably single. In one case a diastolic murmur was heard in the fourth intercostal space from the sternal border to the apex beat, giving rise to the same cadence heard with mitral diastolic murmurs; this was attributed to turbulence set up at the foramen ovale, for no other cause could be found at necropsy. A similar loud diastolic murmur was heard at the apex beat in an uncomplicated case of A.S. D. in which necropsy showed a normal mitral valve. The cardiogram showed sharp P waves from 2 to 5 mm. high in all cases, gross right ventricular pre-ponderance (grade 4) in six, slight right ventricular preponderance in one, and right branch block in one. Radiologically the right heart was enlarged in all but one, and the pulmonary artery was dilated in five (Fig. 15). One of those without post-stenotic dilatation had a valvular stenosis at necropsy; the other exception amongst the proved cases appeared to have a separate infundibular chamber according to the angiocardiogram, but this was not demonstrated on cardiac catheterization. All cases showed evidence of pulmonary ischemia.
Significance of Morphometric Parameters in the Categorization of Breast Lesions on Cytology / Sitolojide Meme Lezyonlarının Sınıflandırılmasında Morfometrik Parametrelerin Önemi

Abstract Objective: The aim of this study was to assess the utility of the morphometric parameters in cytological aspirates in the categorization of breast lesions. Material and Method: The study was carried out on 50 females presenting with a breast lump for fine needle aspiration cytology. Air-dried smears from the aspirate were stained with Leishman and Giemsa stains while alcohol-fixed preparations were stained with the PAP stain. They were subsequently categorized into benign, borderline and malignant categories on light microscopy. Morphometry was performed on the stained smears. The morphometric parameters studied were mean nuclear area, mean cytoplasmic area, perimeter and nuclear/cytoplasm ratio. Results: Morphometric parameters revealed a progressive and statistically significant increase in values from benign to borderline to malignant cases. On comparing benign with borderline and malignant, all the four parameters were found to be statistically significant with a p-value of less than 0.05 while on comparing borderline with malignant, two of the parameters, i.e. mean nuclear area and mean cytoplasmic area, were statistically significant. Conclusion: This study introduces morphometry as a highly objective tool to supplement the entirely subjective fine needle aspiration cytology in the crucial differentiation of benign from malignant lesions and especially the borderline cases in the gray zone comprising of atypical ductal hyperplasia and ductal carcinoma in situ. Öz Amaç: Çalışmanın amacı, meme lezyonlarının sınıflandırılmasında sitolojik aspiratlardaki morfometrik parametrelerin yararının değerlendirilmesidir. Gereç ve Yöntem: Çalışma memede kitle ile nedeni ile ince iğne aspirasyonu yapılan 50 kadın üzerinde gerçekleştirildi. Havada kurutulmuş yayma preparatlar Leishman ve Giemsa ile boyanırken alkol ile tespit edilmiş yaymalar PAP boyası ile boyandı. Olgular sonradan ışık mikroskobu üzerinde benign, borderline ve malign olarak kategorize edilmiştir. Morfometri boyalı preparatlar üzerinde gerçekleştirildi. Çalışılan morfometrik parametreler ortalama çekirdek alanı, ortalama sitoplazmik alan, çevre ve çekirdek/ sitoplazma oranı idi. Bulgular: Morfometrik parametreler benign, borderline ve malign vakalarda sırasıyla giderek artan ve istatistiksel olarak anlamlı bir değer artışı gösterdi. Benign ile borderline ve malign gruplar karşılaştırıldığında , tüm dört parametre istatistiksel olarak anlamlı bulunurken (p<0,05) borderline ve malign grup arasında ortalama çekirdek alanı ve sitoplazmik alan olmak üzere iki parametre istatistiksel olarak anlamlı idi. Sonuç: Bu çalışma benign lezyonların malign ve özellikle atipik duktal hiperplazi ve duktal karsinoma in situ gibi gri zon olgulardan önem taşıyan ayırıcı tanısında tamamen sübjektif ince iğne aspirasyon sitolojisini tamamlamak üzere morfometriyi objektif bir araç olarak sunmaktadır.
Quantifying the Importance of Vantage Points Distribution in Internet Topology Measurements

The topology of the Internet has been extensively studied in recent years, driving a need for increasingly complex measurement infrastructures. These measurements have pro- duced detailed topologies with steadily increasing temporal reso- lution, but concerns exist about the ability of active measurement to measure the true Internet topology. Difficulties in ensuring the accuracy of every individual measurement when millions of measurements are made daily, and concerns about the bias that might result from measurement along the tree of routes from each vantage point to the wider reaches of the Internet must be addressed. However, early discussions of these concerns were based mostly on synthetic data, oversimplified models or data with limited or biased observer distributions. In this paper, we show the importance that extensive sampling from a broad distribution of vantage points has on the resulting topology and bias. We present two methods for designing and analyzing the topology coverage by vantage points: one, when system-wide knowledge exists, provides a near-optimal assign- ment of measurements to vantage points; while the second one is suitable for an oblivious system and is purely probabilistic. The majority of the paper is devoted to a first look at the importance of the distribution's quality. We show that diversity in the locations and types of vantage points is required for obtaining an unbiased topology. We analyze the effect that broad distribution has over the convergence of various autonomous systems topology characteristics. We show that although diverse and broad distribution is not required for all inspected properties, it is required for some. Finally, some recent bias claims that were made against active traceroute sampling are revisited, and we empirically show that diverse and broad distribution can question their conclusions.
Control of Uncertain Nonlinear Systems Using Ellipsoidal Reachability Calculus

Abstract This paper proposes an approach to algorithmically synthesize control strategies for discrete-time nonlinear uncertain systems based on reachable set computations using the ellipsoidal calculus. For given ellipsoidal initial sets and bounded ellipsoidal disturbances, the proposed algorithm iterates over conservatively approximating and LMI-constrained optimization problems to compute stabilizing controllers. The method uses first-order Taylor approximation of the nonlinear dynamics and a conservative approximation of the Lagrange remainder. An example for illustration is included.
Reflections on how art can put critical performativity to work in Management Education and connections with the "performativity dilemma"

We advance a “double performativity” is expected from Management Education. Building on the foundations of performativity, we argue this institution’s performativity can only occur through its agents – who we qualify as per-formateurs – using successful performatives. From there, we explain how management educators are faced with a “performativity dilemma”, i.e. the extent to which management educators want to, and are legitimate to, shape management students through management theories and discourses; we in particular focus on management educators who are interested in Critical Management Education (CME). Through a critical and French sociology framework, we question whether, as many critical management educators believe, critical ideas can be shared through “critical performativity”. In this empirical qualitative paper based on an artistic experiment, we determine whether or not art can help put critical performativity to work in the Management Education context. We use an ethnographic posture both in the academic world and during the workshop, combined with interviews. We show how not respecting conditions of successful (critical) performatives – that is a) wanting to be (critically) performative, b) using a transparent (critical) performative process and c) using codes and social references easy to understand for all –, complemented with us not being critical in critical terms when animating the sessions – for instance using a) “critical taylorism” and b) hoping for an “insidious (critical) performativity” – led to critical performativity at best not fully occurring, largely because we did not take an open and transparent critical stance towards the performativity dilemma.
Sexual dysfunction in obsessive compulsive disorder and panic disorder.

BACKGROUND Clinical research has provided conflicting evidence regarding sexual dysfunction in patients with OCD and PD. This study was undertaken to assess and compare certain parameters of sexual functioning in OCD and PD patients. SUBJECTS AND METHODS The study population consisted of 80 patients between 20 and 60 years of age with a diagnosis of OCD or PD who were followed and treated at the anxiety outpatient unit of Bakirkoy Research and Training Hospital for Psychiatric and Neurological Disorders between 2005 and 2006. The total study population comprised of 40 patients with OCD, 40 patients with PD, and 40 healthy volunteers as the control group. Of the two questionnaires used for study purposes, the first provided information on demographic data and certain parameters of sexual functioning, while the second was the validated Turkish translation of the Golombok-Rust Sexual Satisfaction Inventory with transliteral equivalence. RESULTS Male subjects with OCD had a lower age of first masturbation and first nocturnal ejaculation. Infrequency problem among female and male patients with OCD occurred in 63.6% and 57.1%, respectively. Corresponding figures for PD patients were 36% and 38%. Thus, infrequency problem was more frequent among OCD patients. Sexual avoidance was found in 60.6% of female OCD patients and in 64% of female PD patients. Anorgasmia was detected in 24.2% of the female subjects with OCD. CONCLUSION Sexual dysfunction unrelated to pharmacotherapy has been found to occur in OCD and PD. Assessment of sexual functioning in these individuals before treatment may help prevent deterioration of sexual function that may occur upon introduction of psychotropic medications.
Runaway World: How Globalization is Reshaping Our Lives

'This little book is full of insights about who we are and where we are going. ' - Financial Times The most accessible book yet by one of the most influential thinkers of our time, Runaway World evaluates the ever-increasing impact of globalization today. Extending his arguments beyond the merely economic, Giddens shows how our growing interdependence directly affects our everyday lives. Neither a cheerleading endorsement of emerging markets, nor a fearful rant on the growth of terrorism or loss of American jobs, this is a book about a world that grows smaller every day, and how those changes are affecting our culture, our traditions, our families, and our politics. Identifying globalization as a true cultural force, this eloquent and important volume is the starting point for anyone concerned about our increasingly interconnected world.
Regulation of carbon flow in Selenomonas ruminantium grown in glucose-limited continuous culture

We have applied a model that permits the estimation of the sensitivity of flux through branch point enzymes (D. C. LaPorte, K. Walsh, and D. E. Koshland, J. Biol. Chem. 259:14068-14075, 1984) in order to analyze the control of flux through the lactate-acetate branch point of Selenomonas ruminantium grown in glucose-limited continuous culture. At this branch point, pyruvate is the substrate of both the NAD-dependent L-(+)-lactate dehydrogenase (LDH) and the pyruvate:ferredoxin oxidoreductase (PFOR). The LDH was purified, and it exhibited positive cooperativity for the binding of pyruvate. The LDH had an [S]. 5 for pyruvate of 0.43 mM, a Hill coefficient of 2.4, and a K' equal to 0.13 mM. The PFOR, assayed in cell extracts, exhibited Michaelis-Menten kinetics for pyruvate, with a Km of 0.49 mM. Carbon flux through the LDH and the PFOR increased 80-fold and 3-fold, respectively, as the dilution rate was increased from 0.07 to 0.52 h-1 in glucose-limited continuous culture. There was nearly a twofold increase, from 6.5 to 11.2 mumol min-1 mg of protein-1 in the specific activity (i.e., maximum velocity) of the LDH at dilution rates of 0.11 and 0.52 h-1, respectively. A flux equation was used to calculate the intracellular concentration of pyruvate; a fourfold increase in pyruvate, from 0.023 to 0.093 mM, was thereby predicted as the dilution rate was increased from 0.07 to 0.52 h-1. When these calculated values of intracellular pyruvate concentration were inserted into the flux equation, the predicted values of flux through the LDH and the PFOR were found to match closely the flux actually measured in the chemostat-grown cells. Thus, the 80-fold increase in flux through the LDH was due to a twofold increase in the maximum velocity of the LDH and a fourfold increase in the intracellular pyruvate concentration. In addition, the flux through the LDH exhibited ultrasensitivity to changes in both the maximum velocity of the LDH and the intracellular concentration of pyruvate. The flux through the PFOR exhibited ultrasensitivity to changes in the maximum velocity of the LDH and hyperbolic sensitivity to changes in the intracellular concentration of pyruvate.
Neurophysiological Correlates of Biased Cognitive Processing in Addiction

Several studies indicate that individuals with substance use disorders (SUD) exhibit biases in the cognitive processing of substance-related stimuli. These biases facilitate the detection and selection of substance cues and have been argued to play a causal or perpetuating role in the reactivity to substance cues. Indeed, mounting evidence suggests that these cognitive processing biases are important in addictive behaviors. Two electrophysiological indices of cognitive processing, the P300 and Late Positive Potential (LPP) components of the event-related potential (ERP), are associated with the deployment of attentional resources to motivationally relevant stimuli. In the present metaanalysis P300 and LPP amplitudes are used to investigate whether SUD persons show enhanced cognitive processing of substance cues relative to neutral cues as opposed to healthy control participants. Seventeen studies yielding 30 independent subject samples and six studies yielding ten independent samples were selected for meta-analysis assessing cue-elicited P300 and LPP responses, respectively. Results indicated the P300 and LPP amplitude effect sizes were significantly larger in addicted participants than in controls. This result can be explained by substance users’ motivated attention, that is, the allocation of attention and memory resources to stimuli relevant to substance users’ motivational states. Additional stratified moderator analyses revealed that both P300 and LPP amplitudes were not moderated by electrode site (Fz vs. Pz), type of substance used (stimulants vs. depressants), substance use status (abstinent vs. non-abstinent), age, gender and task requirements (active vs. passive paradigms). These results indicate that enhanced electrophysiological processing of substance cues appears characteristic of SUD in general, might be independent of recency of substance use, and presumably occurs irrespective of task demands.
When query expansion fails

The effectiveness of queries in information retrieval can be improved through query expansion. This technique automatically introduces additional query terms that are statistically likely to match documents on the intended topic. However, query expansion techniques rely on fixed parameters. Our investigation of the effect of varying these parameters shows that the strategy of using fixed values is questionable.
Tourism and sex: culture, commerce and coercion.

1. Tourism, international travel and sex: themes and research - Simon Carter & Stephen Clift. PART ONE: TOURISM AND COMMERCIAL SEX. 2. Sex tourism: paradigms of confusion - Chris Ryan. 3. Tourism and 'embodied commodities: sex tourism in the Caribbean - Jacqueline Sanchez Taylor. 4. Sex tourism and child prostitution - Julia OConnell Davidson. 5. Combatting tourist sexual exploitation of children - Jayne Hoose, Stephen Clift & Simon Carter. 6. Tourism and commercial sex in Indonesia - Kathleen Ford & Dewa Nyoman Wirawan. 7. The use of commercial sex venues and male escorts by gay tourists in New York City - Michael Luongo. 8. Sex in the tourist city: the development of commercial sex as part of the provision of tourist services - Simon Carter. PART TWO: TOURISM, SEXUAL ACTIVITY AND RISK. 9. Sexual risk behaviour in a sample of 5,676 young, unaccompanied travellers - Michael Bloor et al. 10. Studies of sexual risk behaviour among clinic attendees - Graham Hart & Sarah Hawkes. 11. Tourism and the sexual ecology of gay men - Stephen Clift & Simon Forrest. 12. Exploring the contexts and meanings of womens experiences of sexual intercourse on holiday - Michelle Thomas. 13. EscapeEs: What kind of ecstasy are rave holiday-makers seeking? - Furzana Khan et al. 14. Locality, loyalty and identity: experience of travel and marriage among young Punjabi women in Glasgow - Hannah Bradby. 15. Sex and travel: making the links - Paula Black Epilogue. 16. Tourism and sex: critical issues and new directions - Stephen Clift & Simon Carter.
Branch-and-Price Guided Search for Integer Programs with an Application to the Multicommodity Fixed-Charge Network Flow Problem

We develop an exact algorithm for integer programs that uses restrictions of the problem to produce high-quality solutions quickly. Column generation is used both for generating these problem restrictions and for producing bounds on the value of the optimal solution. The performance of the algorithm is greatly enhanced by using structure, such as arises in network flow type applications, to help define the restrictions that are solved. In addition, local search around the current best solution is incorporated to enhance overall performance. The approach is parallelized and computational experiments on a classical problem in network design demonstrate its efficacy.
Chronic colitis in baboons: similarities with chronic colitis in humans.

In recent years, a substantial number of baboons died at the Southwest Foundation for Biomedical Research following protracted intractable diarrheas. The histopathologic diagnosis at autopsy was chronic colitis. The diarrhea could last for more than one year and occurred in infants, juveniles or young adult baboons, i.e. < or = 8 years of age (a healthy baboon may live up to 27 years). The aim was to assess the histopathologic subtype of chronic colitis in a relatively large number of colonic specimens obtained at autopsy (n = 132). In 88 out of 132 baboons with chronic diarrhea, the colonic mucosa was well preserved for histological examination. At review, various histological phenotypes of chronic colitis were disclosed in 86 of the 88 baboons. Chronic lymphocytic-plasmacytic colitis was found in 54.6% (47 out of 86), chronic ulcerative colitis in 15.1% (13 out of 86), Crohn's colitis in 12.8% (11 out of 86), superficial lymphocytic colitis in 10.5% (9 out of 86), cryptal lymphocytic colitis in 5.8% (5 out of 86) and collagenous colitis in 1.2% (1 out of 86). Chronic ulcerative colitis, Crohn's colitis, superficial lymphocytic colitis and collagenous colitis in baboons closely mimic corresponding histological phenotypes of chronic colitis in humans. Recently, cryptal lymphocytic colitis has also been found in humans. The awareness that chronic colitis in baboons is not one disease but a series oi chronic inflammatory changes, having common clinical symptoms and similar gross appearance, may lead to the correct diagnosis of the subtype of the disease. Only then would it be feasible to systematically initiate the search for the corresponding etiologic agent(s), aiming to tailor specific therapeutic strategies in those animals.
Genome-Wide Association Study of Height and Body Mass Index in Australian Twin Families

Abstract Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at ∼550,000 genotyped SNPs. We identified a single genome-wide significant variant for height (P value = 1.06 × 10–9) located in HHIP, a well-replicated height-associated gene. Suggestive levels of association were found for other known genes associated with height (P values < 1 × 10–6): ADAMTSL3, EFEMP1, GPR126, and HMGA2; and BMI (P values < 1 × 10–4): FTO and MC4R. Together, these variants explain less than 2% of total phenotypic variation for height and 0.5% for BMI.
Faktor-Faktor Pemanfaatan Teknologi Informasi dan Pengaruhnya Terhadap Kinerja Individual (Studi pada PDAM Kota Malang)

Penelitian ini bertujuan: 1) Untuk mengetahui pengaruh faktor sosial terhadap pemanfaatan teknologi informasi 2) Untuk mengetahui pengaruh faktor perasaan terhadap pemanfaatan teknologi informasi. 3) Untuk mengetahui pengaruh faktor kompleksitas terhadap pemanfaatan teknologi informasi. 4) Untuk mengetahui pengaruh faktor kesesuaian tugas terhadap pe/. manfaatan teknologi informasi. 5) Untuk mengetahui pengaruh faktor konsekuensi jangka panjang terhadap pemanfaatan teknologi informasi. 6) Untuk mengetahui pengaruh faktor kondisi yang memfasilitasi penggunaan Personal Computer terhadap pemanfaatan teknologi informasi. 7) Untuk mengetahui pengaruh pemanfaatan teknologi informasi terhadap kinerja individual. Jenis penelitian yang digunakan adalah penelitian inferensial yaitu penelitian yang dilakukan tidak hanya menggambarkan obyek yang diteliti, tetapi juga memberikan kesimpulan umum dari masalah yang diteliti. Populasi dalam penelitian ini adalah pegawai yang bekerja di Kantor PDAM Kota Malang yang berjumlah 254 dan sampel dapat ditentukan sebanyak 120 responden. Teknik analisis data yang digunakan yaitu menggunakan analisis regresi linier berganda dengan uji F dan uji T. Hasil dari penelitian yang telah dilakukan menunjukkan bahwa faktor perasaan, kesesuaian tugas, dan konsekuensi jangka panjang berpengaruh positif dan signifikan terhadap pemanfaatan teknologi informasi. Sedangkan faktor sosial dan kondisi yang memfasilitasi berpengaruh positif namun tidak signifikan. Faktor kompleksitas menunjukkan pengaruh yang negatif dan signifikan terhadap pemanfaatan teknologi informasi. Sedangkan pemanfaatan teknologi informasi itu sendiri akan berpengaruh positif dan signifikan kinerja individual. Kata Kunci: Faktor Sosial, Perasaan, Kompleksitas, Kesesuaian Tugas, Konsekuensi Jangka Panjang, Kondisi yang Memfasilitasi, Pemanfaatan Teknologi Informasi, Kinerja Individual