Miracle-dz/UniFAR-FTUs huggingface dataset:
Composition and diurnal variability of the natural Amazonian aerosol

As part of the Large-Scale Biosphere-Atmosphere Experiment in Amazonia (LBA)-Cooperative LBA Airborne Regional Experiment (CLAIRE) 2001 campaign, separate day and nighttime aerosol samples were collected in July 2001 at a ground-based site in Amazonia, Brazil, in order to examine the composition and temporal variability of the natural “background” aerosol. A combination of analytical techniques was used to characterize the elemental and ionic composition of the aerosol. Major particle types larger than ∼0.5 μm were identified by electron and light microscopy. Both the coarse and fine aerosol were found to consist primarily of organic matter (∼70 and 80% by mass, respectively), with the coarse fraction containing small amounts of soil dust and sea-salt particles and the fine fraction containing some non-sea-salt sulfate. Coarse particulate mass concentrations (CPM ≈ PM_(10) − PM_2) were found to be highest at night (average = 3.9 ± 1.4 μg m^(−3), mean night-to-day ratio = 1.9 ± 0.4), while fine particulate mass concentrations (FPM ≈ PM_2) increased during the daytime (average = 2.6 ± 0.8 μg m^(−3), mean night-to-day ratio = 0.7 ± 0.1). The nocturnal increase in CPM coincided with an increase in primary biological particles in this size range (predominantly yeasts and other fungal spores), resulting from the trapping of surface-derived forest aerosol under a shallow nocturnal boundary layer and a lake-land breeze effect at the site, although active nocturnal sporulation may have also contributed. Associated with this, we observed elevated nighttime concentrations of biogenic elements and ions (P, S, K, Cu, Zn, NH_4^+) in the CPM fraction. For the FPM fraction a persistently higher daytime concentration of organic carbon was found, which indicates that photochemical production of secondary organic aerosol from biogenic volatile organic compounds may have made a significant contribution to the fine aerosol. Dust and sea-salt-associated elements/ions in the CPM fraction, and non-sea-salt sulfate in the FPM fraction, showed higher daytime concentrations, most likely due to enhanced convective downward mixing of long-range transported aerosol.
Pontine Nitric Oxide Modulates Acetylcholine Release, Rapid Eye Movement Sleep Generation, and Respiratory Rate

Pontine cholinergic neurotransmission is known to play a key role in the regulation of rapid eye movement (REM) sleep and to contribute to state-dependent respiratory depression. Nitric oxide (NO) has been shown to alter the release of acetylcholine (ACh) in a number of brain regions, and previous studies indicate that NO may participate in the modulation of sleep/wake states. The present investigation tested the hypothesis that inhibition of NO synthase (NOS) within the medial pontine reticular formation (mPRF) of the unanesthetized cat would decrease ACh release, inhibit REM sleep, and prevent cholinergically mediated respiratory depression. Local NOS inhibition by microdialysis delivery of NG-nitro-l-arginine (NLA) significantly reduced ACh release in the cholinergic cell body region of the pedunculopontine tegmental nucleus and in the cholinoceptive mPRF. A second series of experiments demonstrated that mPRF microinjection of NLA significantly reduced the amount of REM sleep and the REM sleep-like state caused by mPRF injection of the acetylcholinesterase inhibitor neostigmine. Duration but not frequency of REM sleep epochs was significantly decreased by mPRF NLA administration. Injection of NLA into the mPRF before neostigmine injection also blocked the ability of neostigmine to decrease respiratory rate during the REM sleep-like state. Taken together, these findings suggest that mPRF NO contributes to the modulation of ACh release, REM sleep, and breathing.
Basic Religious Beliefs and Personality Traits

Objective Spiritual beliefs can help people find meaning of life, and can also influence their feelings, behaviors and mental health. The present research studied the relationship between basic religious beliefs (Human, Existence and God) and five personality factors: neuroticism, extraversion, openness, agreeableness, conscientiousness. Method One hundred seventy eight students of Islamic Azad University in Torbat-jam were randomly selected and completed the basic religious beliefs and NEO Questionnaires. Results Data showed that basic religious beliefs have a significant negative correlation with neuroticism (r=-0.29),and a significant positive relationship with extraversion(r=0.28),openness(r=0.14),agreeableness (r=0.29),and conscientiousness (r=0.48). Also, the results of the regression analysis showed that basic religious beliefs can anticipate neuroticism, extraversion, agreeableness and conscientiousness, but they cannot anticipate the openness factor significantly. Conclusion The findings of this study demonstrate that basic religious beliefs have a positive relationship with good characteristics that help people resolve the challenges of their lives and identity crisis. Thus, the results of this study support the idea of Religious Cognitive–Emotional Theory that religiosity is correlated with positive personality traits.
Modeling and analyzing the effects of firewalls and NATs in P2P swarming systems

Many P2P systems have been designed without taking into account an important factor: a large fraction of Internet users nowadays are located behind a network address translator (NAT) or a firewall, making them unable to accept incoming connections (i.e. unconnectable). Peers suffering from this limitation cannot fully enjoy the advantages offered by the P2P architecture and thus they are likely to get a poor performance. In this work, we present a mathematical model to study the performance of a P2P swarming system in the presence of unconnectable peers.We quantify the average download speeds of peers and find that unconnectable peers achieve a lower average download speed compared to connectable peers, and this difference increases hyperbolically as the percentage of unconnectable peers grows. More interestingly, we notice that connectable peers actually benefit from the existence of peers behind NATs/firewalls, since they alone can enjoy the bandwidth that those peers offer to the system. Inspired by these observations, we propose a new policy for the allocation of the system's bandwidth that can mitigate the performance issues of unconnectable peers. In doing so, we also find an intrinsic limitation in the speed improvement that they can possibly achieve.
Transplantation in Diabetic Kidney Failure Patients: Modalities, Outcomes, and Clinical Management

Diabetes mellitus (DM) is a common and devastating disease, affecting up to 19.3 million Americans. It is the leading cause of chronic kidney disease (CKD) and end‐stage renal disease (ESRD) in the United States. Diabetic patients with ESRD have a high incidence of cardiovascular disease and death. For those kidney transplant patients with no history of DM prior to transplantation, the development of new onset diabetes after transplantation (NODAT) also poses a serious threat to both graft and patient survival. Kidney transplantation is the best renal replacement option for diabetic ESRD and has the potential to halt the progression of cardiovascular diseases. Early referral for transplant evaluation is essential for pre‐emptive or early kidney transplantation in this cohort of patients. In type 1 DM patients with ESRD, simultaneous pancreas and kidney transplantation (SPK) should be encouraged; and in patients facing prolonged waiting time for SPK transplantation but with an available living donor, living donor kidney transplantation followed by pancreas after kidney transplantation (PAK) is a suitable alternative. Islet transplantation in type 1 diabetics is deemed experimental by Medicare, and easy access to this modality remains restricted to qualified patients enrolled in clinical trials or with private insurance. The optimal management of kidney transplant patients with pre‐existent DM or NODAT involves a multi‐pronged approach consisting of pharmacological and nonpharmacological intervention to address all potential cardiovascular risk factors such as glycemic and lipid control, blood pressure control, weight loss, and smoking cessation. Finally, re‐transplantation should be recommended in suitable kidney transplant patients when the kidney allograft demonstrates continuous and progressive decline in function.
Beyond media richness: an empirical test of media synchronicity theory

One widely accepted theory on media use is media richness theory. However, media richness theory was developed without consideration of new electronic media and the many social factors that can influence media selection, communication processes, and outcomes. Recent empirical investigations have raised questions about media richness theory's applicability to these new media. Therefore, the paper presents a new theory called media synchronicity theory (MST) which proposes that all tasks are composed of two fundamental communication processes (conveyance and convergence). Thus, communication effectiveness is influenced by matching the media capabilities to the needs of the fundamental communication processes, not aggregate collections of these processes (i.e., tasks) as rested in examinations of media richness theory. A laboratory experiment was conducted to provide an initial investigation into the theoretical underpinnings of MST. The study examined the influence of different media on conveyance and convergence effectiveness. Results from the study provide preliminary support for the concepts embodied in MST.
Brain and Pituitary Response to Vaccination in Gilthead Seabream (Sparus aurata L.)

Vaccination is a widely used therapeutical strategy in aquaculture, but whether vaccination elicits stress responses in the central neuroendocrine system and enhances the crosstalk between the immune and endocrine systems in the brain or pituitary after vaccination is unclear. To answer this question two experiments using two different vaccine exposure routes, i.e., bath or intraperitoneal (i.p.) injection, were carried out on gilthead seabream (Sparus aurata L.). In the first one, the stress responses of fish subjected to waterborne Vibrio anguillarum bacterin were compared with responses after air exposure or their combination. In the second experiment, fish were subjected to an intraperitoneal injection of Lactococcus garvieae bacterin and we assessed the central stress response and also whether or not a significant immune response was induced in brain and pituitary. In both experiments, blood, brain and pituitary tissues were collected at 1, 6, and 24 h post stress for plasma hormone determination and gene expression analysis, respectively. Results indicated that bath vaccination induced a decreased central stress response compared to air exposure which stimulated both brain and pituitary stress genes. In the second experiment, injection vaccination kept unchanged plasma stress hormones except cortisol that raised at 6 and 24 h. In agreement, non-significant or slight changes on the transcription of stress-related genes were recorded, including the hormone genes of the hypothalamic pituitary interrenal (HPI) axis and other stress markers such as hsp70, hsp90, and mt genes in either brain or pituitary. Significant changes were observed, however, in crhbp and gr. In this second experiment the immune genes il1β, cox2, and lys, showed a strong expression in both brain and pituitary after vaccination, notably il1β which showed more than 10 fold raise. Overall, vaccination procedures, although showing a cortisol response, did not induce other major stress response in brain or pituitary, regardless the administration route. Other than main changes, the alteration of crhbp and gr suggests that these genes could play a relevant role in the feedback regulation of HPI axis after vaccination. In addition, from the results obtained in this work, it is also demonstrated that the immune system maintains a high activity in both brain and pituitary after vaccine injection.
Traditional Femininity Versus Strong Black Women Ideologies and Stress Among Black Women

The construct of femininity has typically been conceptualized from a Eurocentric perspective as traditional femininity ideology (TFI). This hegemonic femininity construction might not be fully applicable to African American women given their unique history and experiences. Moreover, the strong Black woman ideology (SBWI) which, although formulated during slavery, has become an adaptive and idealized cultural idealization. Both constructs have been associated with stress. The current study sought to investigate the relative strength of the links between TFI versus SBWI and perceived stress among a sample of African American women, and whether these relationships were moderated by feminine gender role stress and racial stress. Participants were 292 African American women recruited via social media and students from a Midwestern university for a web-based survey. As hypothesized, SBWI accounted for unique variance in perceived stress; however, TFI did not explain any of the variance. Results also indicated that gender role stress approached significance in its moderation of the link between TFI and perceived stress, although racial stress did significantly moderate the relationship between SBWI and perceived stress.
Addressing Health Inequalities in the Delivery of the Human Papillomavirus Vaccination Programme: Examining the Role of the School Nurse

Background HPV immunisation of adolescent girls is expected to have a significant impact in the reduction of cervical cancer. UK The HPV immunisation programme is primarily delivered by school nurses. We examine the role of school nurses in delivering the HPV immunisation programme and their impact on minimising health inequalities in vaccine uptake. Methods and Findings A rapid evidence assessment (REA) and semi-structured interviews with health professionals were conducted and analysed using thematic analysis. 80 health professionals from across the UK are interviewed, primarily school nurses and HPV immunisation programme coordinators. The REA identified 2,795 articles and after analysis and hand searches, 34 relevant articles were identified and analysed. Interviews revealed that health inequalities in HPV vaccination uptake were mainly related to income and other social factors in contrast to published research which emphasises potential inequalities related to ethnicity and/or religion. Most school nurses interviewed understood local health inequalities and made particular efforts to target girls who did not attend or missed doses. Interviews also revealed maintaining accurate and consistent records influenced both school nurses' understanding and efforts to target inequalities in HPV vaccination uptake. Conclusions Despite high uptake in the UK, some girls remain at risk of not being vaccinated with all three doses. School nurses played a key role in reducing health inequalities in the delivery of the HPV programme. Other studies identified religious beliefs and ethnicity as potentially influencing HPV vaccination uptake but interviews for this research found this appeared not to have occurred. Instead school nurses stated girls who were more likely to be missed were those not in education. Improving understanding of the delivery processes of immunisation programmes and this impact on health inequalities can help to inform solutions to increase uptake and address health inequalities in childhood and adolescent vaccination programmes.
The oncolytic virus dl922-947 reduces IL-8/CXCL8 and MCP-1/CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid carcinoma

Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human solid tumor and current treatments are ineffective in increasing patients' survival. Thus, the development of new therapeutic approaches for ATC is needed. We have previously shown that the oncolytic adenovirus dl922-947 induces ATC cell death in vitro and tumor regression in vivo. However, the impact of dl922-947 on the pro-tumorigenic ATC microenvironment is still unknown. Since viruses are able to regulate cytokine and chemokine production from infected cells, we sought to investigate whether dl922-947 virotherapy has such effect on ATC cells, thereby modulating ATC microenvironment. dl922-947 decreased IL-8/CXCL8 and MCP-1/CCL2 production by the ATC cell lines 8505-c and BHT101-5. These results correlated with dl922-947-mediated reduction of NF-κB p65 binding to IL8 promoter in 8505-c and BHT101-5 cells and CCL2 promoter in 8505-c cells. IL-8 stimulates cancer cell proliferation, survival and invasion, and also angiogenesis. dl922-947-mediated reduction of IL-8 impaired ATC cell motility in vitro and ATC-induced angiogenesis in vitro and in vivo. We also show that dl922-947-mediated reduction of the monocyte-attracting chemokine CCL2 decreased monocyte chemotaxis in vitro and tumor macrophage density in vivo. Interestingly, dl922-947 treatment induced the switch of tumor macrophages toward a pro-inflammatory M1 phenotype, likely by increasing the expression of the pro-inflammatory cytokine interferon-γ. Altogether, we demonstrate that dl922-947 treatment re-shape the pro-tumorigenic ATC microenvironment by modulating cancer-cell intrinsic factors and the immune response. An in-depth knowledge of dl922-947-mediated effects on ATC microenvironment may help to refine ATC virotherapy in the context of cancer immunotherapy.
Lattice chirality, anomaly matching, and more on the (non)decoupling of mirror fermions

We study 't Hooft anomaly matching in lattice models with strong Yukawa or multi-fermion interactions. Strong non-gauge interactions among the mirror fermions in a vectorlike lattice gauge theory are introduced with the aim to obtain, in a strong-coupling symmetric phase, a long-distance unbroken gauge theory with chiral fermions in a complex representation. We show how to use exact lattice chirality to analyze the anomaly matching conditions on chiral symmetry current correlators at finite lattice spacing and volume. We perform a Monte Carlo study of the realization of anomaly matching in a toy two-dimensional model with an anomalous mirror-fermion content at strong mirror Yukawa coupling. We show that 't Hooft anomaly matching is satisfied, in most of the phase diagram, via the minimal solution in either the massless fermion or ``Goldstone mode, while in some cases there are extra massless vectorlike mirror fermions. The mirror spectrum at strong coupling is thus consistent with long-distance unitarity. We discuss the implications of our results for future studies of the most interesting case of the decoupling of anomaly-free mirror-fermion sectors.
Relationship and sexual satisfaction: a longitudinal actor–partner interdependence model approach

ABSTRACT Research has demonstrated a strong link between relationship and sexual satisfaction in the context of romantic relationships. However, little research has examined this in the context of a dyadic longitudinal sample, where both partner and actor effects are considered over time. The current study aimed to assess directional fit of the link between relationship and sexual satisfaction with the actor–partner interdependence model (APIM) on the cross-sectional and longitudinal level. Data were collected online from 204 mixed-sex couples (408 individuals) in an online quantitative longitudinal study (baseline, 2 months, and 4 months). The average age of participants was 34 and participants were in a relationship for an average of nine years. Results from the cross-sectional APIM indicated that relationship satisfaction as a predictor of sexual satisfaction provided a better fit to the data. The over-time APIM further supported this directionality. Although prior research has shown mixed results, with some studies providing support for a bidirectional model, the current results indicated that relationship satisfaction precedes sexual satisfaction. This provides additional support that targeting relationship building to improve relationship satisfaction may be a fruitful approach to improving sexual satisfaction in relationships. Implications of the findings and directions for future research are discussed.
Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference

Eukaryotic cap-dependent mRNA translation is mediated by the initiation factor eIF4E, which binds mRNAs and stimulates efficient translation initiation. eIF4E is often overexpressed in human cancers. To elucidate the molecular signature of eIF4E target mRNAs, we analyzed sequence and structural properties of two independently derived polyribosome recruited mRNA datasets. These datasets originate from studies of mRNAs that are actively being translated in response to cells over-expressing eIF4E or cells with an activated oncogenic AKT: eIF4E signaling pathway, respectively. Comparison of eIF4E target mRNAs to mRNAs insensitive to eIF4E-regulation has revealed surprising features in mRNA secondary structure, length and microRNA-binding properties. Fold-changes (the relative change in recruitment of an mRNA to actively translating polyribosomal complexes in response to eIF4E overexpression or AKT upregulation) are positively correlated with mRNA G+C content and negatively correlated with total and 3′UTR length of the mRNAs. A machine learning approach for predicting the fold change was created. Interesting tendencies of secondary structure stability are found near the start codon and at the beginning of the 3′UTR region. Highly upregulated mRNAs show negative selection (site avoidance) for binding sites of several microRNAs. These results are consistent with the emerging model of regulation of mRNA translation through a dynamic balance between translation initiation at the 5′UTR and microRNA binding at the 3′UTR.
The politics of sovereign default under financial integration∗

In this paper we study the role of portfolio diversification on optimal default of sovereign debt in a two-country model with large economies that are financially integrated. Financial integration increases the incentives to default not only because part of the defaulted debt is owned by foreigners (the standard redistribution channel), but also because the endogenous macroeconomic cost for the defaulting country is smaller when financial markets are integrated. We show that the sovereign default of one country may be triggered by higher debt (liquidity) issued by other countries. Because the macroeconomic costs of default spill to other countries, creditor countries may find it beneficial ex-post to bail-out debtor countries. Although bailouts create moral hazard problems, they can be welfare improving also ex-ante. ∗We would like to thank seminar and conference participants for helpful comments at the Atlanta Fed, Bank of Canada, Claremont McKenna College, Minnesota Workshop in Macroeconomic Theory, Penn State University, Philadelphia Fed, SED meeting in Toulouse, University of California San Diego, University of Georgia, University of Wisconsin, the Stockman Conference at the University of Rochester.
How Principals of Successful Schools Enact Education Policy: Perceptions and Accounts From Senior and Middle Leaders

ABSTRACT This article investigates, from the perspective of senior and middle leaders, how secondary principals in England lead their schools to achieve sustainable performance despite policy shifts. Empirical data were drawn from structural equation modeling (SEM) analyses of a questionnaire survey from 309 effective and improved secondary schools in England and longitudinal interview data from a subsample of four case-study schools. The research suggests that what the principals were perceived to be doing successfully was to use policies as opportunities—purposefully, progressively, and strategically—to regenerate coherent cultures and conditions which support the staff to learn to renew their practice.