Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of N-acetyl cysteine on serum lipoprotein (a) and proteinuria in type 2 diabetic patients.

BACKGROUND About 30-40% of diabetic patients who developed nephropathy have lipoprotein disorders, especially lipoprotein a [Lp(a)], which is related to atherosclerosis. OBJECTIVES The aim of this study was to investigate the effect of N-acetyl cysteine (NAC) on the serum levels of Lp(a) and amount of proteinuria in a group of type 2 diabetic patients with diabetic nephropathy. PATIENTS AND METHODS A total of 40, type 2 diabetic (T2D) patients, patients with proteinuria, were randomly divided into two groups. The experimental group was treated by NAC (1200 mg/day) for two months in conjunction with conventional treatment for diabetes and hypertension. Control group received routine medications. RESULTS No significant change was identified in serum Lp(a) during treatment with NAC (P >0.05). However, NAC decreased the amount of proteinuria, serum triglyceride (TG) level and systolic blood pressure in experimental group compared to the control group (P <0.05). CONCLUSIONS These findings suggest that treatment with NAC has no significant effect on the serum level of Lp (a). However, it has beneficial effects on the reduction of proteinuria, serum TG level and systolic blood pressure in T2D patients with nephropathy. Further prospective studies are needed to determine its full role.
A unity power factor buck type PWM rectifier for medium/high power DC motor drive applications

This paper describes the application of a single stage unity PF buck type PWM rectifier to medium and high power variable speed DC motor drives. The advantages of the developed system are low harmonic distortion in AC supply currents (comply with IEEE Std. 519 and IEC 555), nearly unity PF over a wide operating shaft speed range, nearly level armature-current and -voltage waveforms. These properties of output voltage and current quantities of the converter eliminate entirely any failure risk in current commutation even for oldest motor designs, and further motor problems such as accelerated ageing in motor insulation, and mechanical failure due to circulating bearing currents. The design criteria and operating-features and -characteristics of the buck type PWM rectifier employed in unity PF DC motor drive are discussed in the paper. The performance of the resulting system has been tested on 25-65 kW, 100-150 A, 10-20 kHz DC motor drives, used in various processes of an iron and steel plant.
Life history context of reproductive aging in a wild primate model

The pace of reproductive aging has been of considerable interest, especially in regard to the long postreproductive period in modern women. Here we use data for both sexes from a 37‐year longitudinal study of a wild baboon population to place reproductive aging within a life history context for this species, a primate relative of humans that evolved in the same savannah habitat as humans did. We examine the patterns and pace of reproductive aging, including birth rates and reproductive hormones for both sexes, and compare reproductive aging to age‐related changes in several other traits. Reproductive senescence occurs later in baboon females than males. Delayed senescence in females relative to males is also found in several other traits, such as dominance status and body condition, but not in molar wear or glucocorticoid profiles. Survival, health, and well‐being are the product of risk factors in morphological, physiological, and behavioral traits that differ in rate of senescence and in dependence on social or ecological conditions; some will be very sensitive to differences in circumstances and others less so.
Framing and Free Riding: Emotional Responses and Punishment in Social Dilemma Games Framing and Free Riding: Emotional Responses and Punishment in Social Dilemma Games

The focus for the Centre is research into individual and strategic decision-making using a combination of theoretical and experimental methods. On the theory side, members of the Centre investigate individual choice under uncertainty, cooperative and non-cooperative game theory, as well as theories of psychology, bounded rationality and evolutionary game theory. Members of the Centre have applied experimental methods in the fields of Public Economics, Individual Choice under Risk and Uncertainty, Strategic Interaction, and the performance of auctions, markets and other economic institutions. Much of the Centre's research involves collaborative projects with researchers from other departments in the UK and overseas. Abstract In this paper, we report an experimental investigation of the effect of framing on social preferences, as revealed in a one-shot linear public goods game. We use two indicators to measure social preferences: self-reported emotional responses; and, as a behavioural indicator of disapproval, punishment. Our findings are that, for a given pattern of contributions, neither punishment nor emotion depends on the Give versus Take framing that we manipulate. To this extent, they suggest that the social preferences we observe are robust to framing effects.
Restored perfusion and reduced inflammation in the infarcted heart after grafting stem cells with a hyaluronan-based scaffold

The aim of this study is to investigate the blood perfusion and the inflammatory response of the myocardial infarct area after transplanting a hyaluronan‐based scaffold (HYAFF®11) with bone marrow mesenchymal stem cells (MSCs). Nine‐week‐old female pigs were subjected to a permanent left anterior descending coronary artery ligation for 4 weeks. According to the kind of the graft, the swine subjected to myocardial infarction were divided into the HYAFF®11, MSCs, HYAFF®11/MSCs and untreated groups. The animals were killed 8 weeks after coronary ligation. Scar perfusion, evaluated by Contrast Enhanced Ultrasound echography, was doubled in the HYAFF®11/MSCs group and was comparable with the perfusion of the healthy, non‐infarcted hearts. The inflammation score of the MSCs and HYAFF®11/MSCs groups was near null, revealing the role of the grafted MSCs in attenuating the cell infiltration, but not the foreign reaction strictly localized around the fibres of the scaffold. Apart from the inflammatory response, the native tissue positively interacted with the HYAFF®11/MSCs construct modifying the extracellular matrix with a reduced presence of collagene and increased amount of proteoglycans. The border‐zone cardiomyocytes also reacted favourably to the graft as a lower degree of cellular damage was found. This study demonstrates that the transplantation in the myocardial infarct area of autologous MSCs supported by a hyaluronan‐based scaffold restores blood perfusion and almost completely abolishes the inflammatory process following an infarction. These beneficial effects are superior to those obtained after grafting only the scaffold or MSCs, suggesting that a synergic action was achieved using the cell‐integrated polymer construct.
On Plant Detection of Intact Tomato Fruits Using Image Analysis and Machine Learning Methods

Fully automated yield estimation of intact fruits prior to harvesting provides various benefits to farmers. Until now, several studies have been conducted to estimate fruit yield using image-processing technologies. However, most of these techniques require thresholds for features such as color, shape and size. In addition, their performance strongly depends on the thresholds used, although optimal thresholds tend to vary with images. Furthermore, most of these techniques have attempted to detect only mature and immature fruits, although the number of young fruits is more important for the prediction of long-term fluctuations in yield. In this study, we aimed to develop a method to accurately detect individual intact tomato fruits including mature, immature and young fruits on a plant using a conventional RGB digital camera in conjunction with machine learning approaches. The developed method did not require an adjustment of threshold values for fruit detection from each image because image segmentation was conducted based on classification models generated in accordance with the color, shape, texture and size of the images. The results of fruit detection in the test images showed that the developed method achieved a recall of 0.80, while the precision was 0.88. The recall values of mature, immature and young fruits were 1.00, 0.80 and 0.78, respectively.
On the psychology of self-prediction: Consideration of situational barriers to intended actions

When people predict their future behavior, they tend to place too much weight on their current intentions, which produces an optimistic bias for behaviors associated with currently strong intentions. More realistic self-predictions require greater sensitivity to situational barriers, such as obstacles or competing demands, that may interfere with the translation of current intentions into future behavior. We consider three reasons why people may not adjust sufficiently for such barriers. First, self-predictions may focus exclusively on current intentions, ignoring potential barriers altogether. We test this possibility, in three studies, with manipulations that draw greater attention to barriers. Second, barriers may be discounted in the self-prediction process. We test this possibility by comparing prospective and retrospective ratings of the impact of barriers on the target behavior. Neither possibility was supported in these tests, or in a further test examining whether an optimally weighted statistical model could improve on the accuracy of self-predictions by placing greater weight on anticipated situational barriers. Instead, the evidence supports a third possibility: Even when they acknowledge that situational factors can affect the likelihood of carrying out an intended behavior, people do not adequately moderate the weight placed on their current intentions when predicting their future behavior.
Neutrophils as a Source of Chitinases and Chitinase-Like Proteins in Type 2 Diabetes

Purpose The pathophysiological role of human chitinases and chitinase-like proteins (CLPs) is not fully understood. We aimed to determine the levels of neutrophil-derived chitotriosidase (CHIT1), acidic mammalian chitinase (AMCase) and chitinase 3-like protein 1 (YKL-40) in patients with type 2 diabetes (T2D) and verify their association with metabolic and clinical conditions of these patients. Methods Neutrophils were obtained from the whole blood by gradient density centrifugation from 94 T2D patients and 40 control subjects. The activities of CHIT1 and AMCase as well as leukocyte elastase (LE) were measured fluorometrically and concentration of YKL-40 immunoenzymatically. Also, routine laboratory parameters in serum/plasma were determined by standard methods. Results The levels of all three examined proteins were about 2-times higher in diabetic patients in comparison to control subjects. They were significantly correlated with the activity of LE and increased progressively across tertiles of LE activity. Moreover, the activities of CHIT1 and AMCase were significantly correlated with each other. Metabolic compensation of diabetes did not influence the levels of these proteins. In the subgroup of patients with inflammatory evidence only YKL-40 concentration was significantly higher compared to those without inflammation. The highest levels of all three proteins were observed in patients with macroangiopathies. Insulin therapy was associated with lower levels of examined proteins. Conclusions We revealed that neutrophils may be an important source of the increased levels of chitinases and CLPs in T2D, and these proteins may participate in inflammatory mechanisms in the course of the disease and consequent development of diabetic angiopathies.
An Accuracy Improving Method for Three Dimensional Location Systems

GPS is especially suitable for use of location systems in wide open areas, but the availability of GPS is limited in highly built-up areas and mountain areas due to the nature of satellite communications. To extend the apparent coverage of the GPS system from a pedestrian's perspective in the mountain areas, the dead reckoning system is generally used during the transit of pedestrians through the non-GPS mountain area. The speeds of pedestrians change according to the inclination of the ground in the slanted areas such as mountains. To reduce location measurement errors, we propose a calculation method for improving accuracy of 3D location decisions using the speeds of pedestrians based on the inclination of the ground. The angle of the inclination is obtained using the contour lines of the mountain and the location of the pedestrians is calculated using this speeds based on the inclination. The simulation results show that this proposed system is more accurate in comparison with the existing location system that uses the average speeds of pedestrians.
Applying the Condensation Particle Counter Battery (CPCB) to study the water-affinity of freshly-formed 2–9 nm particles in boreal forest

Abstract. Measurements on the composition of nanometer-sized atmospheric particles are the key to understand which vapors participate in the secondary aerosol formation processes. Knowledge on these processes is crucial in assessing the climatic effects of secondary aerosol formation. We present data of >2 nm particle concentrations and their water-affinity measured with the Condensation Particle Counter Battery (CPCB) at a boreal forest site in Hyytiala, Finland, during spring 2006. The data reveal that during new particle formation events, the smallest particles activate for growth at clearly smaller sizes in water than in butanol vapor. However, even at 2–4 nm, there are days when the particles seem to be less hygroscopic than ammonium sulfate or sulfuric acid, which are often referred to as the most likely compounds present in atmospheric nucleation. This observation points to the possible presence of water-soluble organics, even at the very first steps on particle formation. The water-affinity of the particles decreases with size, indicating that the vapors that participate in the first steps of the particle formation and growth are more hygroscopic than the vapors contributing to the later stages of the growth. This suggests that the relative role of less hygroscopic organics in atmospheric particle growth increases as a function of particle size.
Innovation and Entrepreneurship: Journalism Students’ Interpretive Repertoires for a Changing Occupation

ABSTRACT Amid ongoing disruption, discourse about journalism increasingly emphasizes innovation within the newsroom and the rise of entrepreneurial initiatives outside it. This article uses the concept of interpretive repertoires to explore how students enrolled in journalism programmes in Britain and the Netherlands understand innovation and entrepreneurialism in relation to changing industry circumstances and long-standing conceptualizations of occupational norms and behaviours. We find shared repertoires that embrace technological change, but generally within an acceptance of traditional normative practice.
Characterization of the horseweed (Conyza canadensis) transcriptome using GS-FLX 454 pyrosequencing and its application for expression analysis of candidate non-target herbicide resistance genes.

BACKGROUND The de novo transcriptome sequencing of a weedy plant using GS-FLX 454 technologies is reported. Horseweed (Conyza canadensis L.) was the first broadleaf weed to evolve glyphosate resistance in agriculture, and also is the most widely distributed glyphosate-resistant weed in the United States and the world. However, available sequence data for this species are scant. The transcriptomic sequence should be useful for gene discovery, and to help elucidate the non-target-based glyphosate resistance mechanism and the genomic basis of weediness. RESULTS Sequencing experiments yielded 411 962 raw reads, an average read length of 233 bp and a total dataset of 95.8 Mb (NCBI accession number SRA010952). After trimming and quality control, 379 152 high-quality sequences were retained and assembled into contigs. The assembly resulted in 31 783 unique transcripts, including 16 102 contigs and 15 681 singletons. The average coverage depth for each contig and each nucleotide position was 22-fold and 12-fold respectively. A total of 16 306 unique sequences were annotated by searching a custom plant protein database. The utility of the transcriptome data was demonstrated by further exploration of ABC transporters, which were previously hypothesized to play a role in non-target glyphosate resistance. Real-time RT-PCR primers were designed from the transcriptome data, which made it possible to assess expression patterns of 17 ABC transporters from resistant and susceptible horseweed accessions from Tennessee, with and without glyphosate treatment. CONCLUSION These results show that GS-FLX 454 sequencing is a powerful and cost-effective platform for the development of functional genomic tools for a weed species.
Viral and clinical factors associated with the fulminant course of hepatitis A infection

Fulminant hepatitis is a severe complication of hepatitis A virus infection. Its mechanism is unknown. Liver transplantation can be necessary, but spontaneous recovery is frequent. There are no data on the level of viral replication according to the clinical form of hepatitis A. We reviewed the files of 50 patients with acute hepatitis A. Nineteen patients had fulminant hepatitis (defined by encephalopathy and factor V <50%), and, from them, 10 patients underwent transplantation. Hepatitis A virus (HAV) RNA was quantified by real‐time PCR on sera obtained at admission. The genotype was determined by phylogenetic analysis of HAV RNA. HAV RNA was detected in serum by RT‐PCR in 39 out of 50 patients. Encephalopathy and low factor V level were significantly related to female gender, HAV PCR negativity (9/19 vs. 5/31, respectively; P = .03), a low serum HAV RNA level (log, 3.6 ± 0.6 vs. 4.4 ± 0.9, respectively; P = .02), genotypes other than IA, and acetaminophen intake. In multivariate analysis, low or undetectable HAV viral load and a high bilirubin level were independently associated with both low factor V levels and fulminant hepatitis and also with death or transplantation. In conclusion, HAV‐related liver failure is due to an excessive host response associated with a marked reduction in viral load. Serum HAV RNA assay could be of help in the management of severe hepatitis A.
Temporal preview estimation for design of a low cost lane-following system using a forward-facing monocular camera

Computer-based guidance of passenger vehicles is a common reality today, but cost, computation, and robustness challenges remain to obtain accurate vehicle state estimates. This study builds on previous work by the authors towards the development of a vehicle state estimation framework that uses optimal preview control theory to fuse map, GPS, inertial, and forward-looking camera information in a linear filter that offers a-priori predictions of state estimate accuracy. By designing an optimal preview controller around a preview filter designed to make full use of a test vehicle's low-cost sensors, on-board map, and available visibility, a matched perception and control system is obtained. The resulting preview-based guidance system has a structure similar to LQG algorithms, and is tested both in simulation and on a real vehicle. The closed loop system provides lane-level tracking performance with low cost sensors.
CRISP Spectropolarimetric Imaging of Penumbral Fine Structure

We discuss penumbral fine structure in a small part of a pore, observed with the CRISP imaging spectropolarimeter at the Swedish 1-m Solar Telescope (SST), close to its diffraction limit of 0.16″. Milne-Eddington inversions applied to these Stokes data reveal large variations of field strength and inclination angle over dark-cored penumbral intrusions and a dark-cored light bridge. The mid-outer part of this penumbra structure shows ~0.3″ wide spines, separated by ~1.6″ (1200 km) and associated with 30° inclination variations. Between these spines, there are no small-scale magnetic structures that easily can be identified with individual flux tubes. A structure with nearly 10° more vertical and weaker magnetic field is seen midway between two spines. This structure is cospatial with the brightest penumbral filament, possibly indicating the location of a convective upflow from below.
Modelling and Analysis of Autonomous Shop Floor Control

To manage the increasing dynamics inside and outside a production system, a decentralised and autonomous control of shop floor logistics is a promising approach. For developing and benchmarking such autonomous control methods, dynamic models are essential. The paper introduces the idea of autonomous logistic processes and presents a dynamic simulation model of a shop floor with both a conventionally planned and an autonomously controlled scenario. The decentralised and autonomous control strategy bases on autonomous elements that are able to make decisions by themselves using distributed local information. The simulation model is used for analysing the system’s dynamics at varying workloads. The logistic performance is analysed by comparing throughput times for the different logistics situations and during expected and unexpected disturbances.
The Cholesterol-Binding Antibiotic Nystatin Induces Expression of Macrophage Inflammatory Protein-1 in Macrophages

Nystatin, a polyene antifungal antibiotic, is a cholesterol sequestering agent. The antifungal agent alters composition of the plasma membrane of eukaryotic cells, whereas its effects on cells are poorly investigated. In the current study, we investigated the question of whether nystatin was able to induce expression of macrophage inflammatory protein-1 (MIP-1). THP-1 cells rarely express MIP-1α and MIP-1β, however, upon exposure to nystatin, significantly elevated expression of MIP-1α and MIP-1β was observed in a dose-dependent fashion at the messenger and protein levels. Cellular factors activated by nystatin as well as involved in nystatin-induced expression of MIP-1 proteins were identified in order to understand the molecular mechanisms of action of the anti-fungal agent. Treatment with nystatin resulted in enhanced phosphorylation of Akt, ERK, p38 MAPK, and JNK. Abrogation or significant attenuation of nystatin-induced expression of MIP-1α and MIP-1β was observed by treatment with Akt inhibitor IV, LY294002, and SP6001250. Inhibition of ERK or p38MAPK using U0126 and SB202190 did not lead to attenuation of MIP-1 expression. In addition, inhibitors of protein kinase C, such as GF109203X and Ro-318220, also attenuated expression of MIP-1. These results indicate that nystatin is able to activate multiple cellular kinases and, among them, Akt and JNK play primary roles in nystatin-induced expression of MIP-1 proteins.
A Physical Model of Solenoid Inductors on Silicon Substrates

In this paper, a physical model is presented to predict the frequency-dependent characteristics of solenoid-type inductors on standard silicon substrates. The model considers the skin-depth effect in the conductor, interwinding capacitance, parasitic capacitance between the conductor and substrate, substrate resistance, and substrate capacitance of a solenoid inductor on the silicon substrate, which are all computed based on the inductor's geometric dimensions and related material properties. Surface-micromachined inductors of various geometries have been tested to validate the physical model and found a satisfactory consistency between the measured results and the theoretical predictions in the multigigahertz frequency range. It is also suggested that the increase of the solenoid aspect ratio is beneficial in enhancing quality factors of solenoid inductors on the silicon substrate at a high frequency.