Miracle-dz/UniFAR-FTUs huggingface dataset:
Clopidogrel pretreatment in primary percutaneous coronary intervention: Prevalence of high on-treatment platelet reactivity and impact on preprocedural patency of the infarct-related artery

Summary To date, there is limited data on levels of platelet inhibition achieved in patients with ST-elevation myocardial infarction (STEMI) who are loaded with clopidogrel and aspirin (ASA) prior to undergoing primary percutaneous coronary intervention (P-PCI). The aim of this investigation was to evaluate the percentage of STEMI patients with high on-treatment platelet reactivity (HPR) to clopidogrel at the time of initiating P-PCI and its association with the initial patency of the infarct-related artery (IRA). This prospective pharmacodynamic study included 50 STEMI patients, previously naïve to oral antiplatelet agents, who received 500-mg ASA and 600-mg clopidogrel loading doses prior to P-PCI. Platelet function assessment was performed at the beginning of the procedure using various assays, including VerifyNow™ system (primary endpoint), light transmission aggregometry and multiple electrode aggregometry. The percentage of patients with suboptimal response to clopidogrel and ASA assessed with the VerifyNow™ system was 88.0% and 28.6%, respectively. Similar results were obtained with the other assays used. A higher percentage of patients with initial patency of the IRA was observed among those patients without HPR compared with those with HPR to clopidogrel (66.7% vs 15.9%; p=0.013), while no differences were observed regarding postprocedural angiographic or electrocardiographic outcomes. In conclusion, this study shows that a high percentage of STEMI patients have inadequate levels of clopidogrel-induced and, to a lesser extent, aspirin-mediated platelet inhibition when starting a P-PCI procedure, and suggests that a poor response to clopidogrel might be associated with impaired initial TIMI flow in the IRA.
Bevacizumab added to neoadjuvant chemotherapy for breast cancer.

BACKGROUND Bevacizumab and the antimetabolites capecitabine and gemcitabine have been shown to improve outcomes when added to taxanes in patients with metastatic breast cancer. The primary aims of this trial were to determine whether the addition of capecitabine or gemcitabine to neoadjuvant chemotherapy with docetaxel, followed by doxorubicin plus cyclophosphamide, would increase the rates of pathological complete response in the breast in women with operable, human epidermal growth factor receptor 2 (HER2)-negative breast cancer and whether adding bevacizumab to these chemotherapy regimens would increase the rates of pathological complete response. METHODS We randomly assigned 1206 patients to receive neoadjuvant therapy consisting of docetaxel (100 mg per square meter of body-surface area on day 1), docetaxel (75 mg per square meter on day 1) plus capecitabine (825 mg per square meter twice a day on days 1 to 14), or docetaxel (75 mg per square meter on day 1) plus gemcitabine (1000 mg per square meter on days 1 and 8) for four cycles, with all regimens followed by treatment with doxorubicin-cyclophosphamide for four cycles. Patients were also randomly assigned to receive or not to receive bevacizumab (15 mg per kilogram of body weight) for the first six cycles of chemotherapy. RESULTS The addition of capecitabine or gemcitabine to docetaxel therapy, as compared with docetaxel therapy alone, did not significantly increase the rate of pathological complete response (29.7% and 31.8%, respectively, vs. 32.7%; P=0.69). Both capecitabine and gemcitabine were associated with increased toxic effects--specifically, the hand-foot syndrome, mucositis, and neutropenia. The addition of bevacizumab significantly increased the rate of pathological complete response (28.2% without bevacizumab vs. 34.5% with bevacizumab, P=0.02). The effect of bevacizumab on the rate of pathological complete response was not the same in the hormone-receptor-positive and hormone-receptor-negative subgroups. The addition of bevacizumab increased the rates of hypertension, left ventricular systolic dysfunction, the hand-foot syndrome, and mucositis. CONCLUSIONS The addition of bevacizumab to neoadjuvant chemotherapy significantly increased the rate of pathological complete response, which was the primary end point of this study. (Funded by the National Cancer Institute and others; ClinicalTrials.gov number, NCT00408408.).
Seasonal dynamics of Pneumocystis carinii in the field vole, Microtus agrestis, and in the common shrew, Sorex araneus, in Finland

Seasonal dynamics of Pneumocystis carinii in the field vole, Microtus agrestis, and in the common shrew, Sorex araneus, were investigated in southern and central Finland by microscopical examination of methenamine silver-stained tissue sections. In both host species at both localities the number of P. carinii cyst forms was highest in late autumn (November). In S. araneus, prevalence was higher than in M. agrestis during all seasons. None of the animals was heavily infected or apparently ill, and neither species showed any extrapulmonary dissemination. In this study covering an increase phase and 4 peak host-density phases of the vole cycle, the occurrence of P. carinii seemed to be related to the population density of M. agrestis.
Histopathologic features of alopecia areata: a new look.

BACKGROUND A peribulbar lymphocytic infiltrate is the expected histologic feature of alopecia areata, but it is absent in many scalp biopsy specimens. Other diagnostic criteria are needed. OBJECTIVE To establish the histologic features of alopecia areata in scalp biopsy specimens taken from different types of alopecia areata, using follicular counts to relate biopsy findings to stages of the disease. METHODS Fifty consecutive new patients with alopecia areata were studied. Four-millimeter punch biopsy specimens were taken from the scalp in areas of recent, active hair loss; old, inactive hair loss; or recent hair regrowth. Specimens were sectioned horizontally. Terminal and vellus-like hairs were counted. Inflammation and fibrosis around lower and upper follicles were rated. RESULTS The histopathologic features of alopecia areata were not significantly affected by the sex, age, and race of the patient or by the type, percentage of hair loss, total duration, or regression of alopecia areata. The major factor affecting the histopathologic features was the duration of the current episode of alopecia areata. In the acute stage, bulbar lymphocytes surrounded terminal hairs in early episodes and miniaturized hairs in repeated episodes. In the subacute stage, decreased anagen and increased catagen and telogen hairs were characteristic. In the chronic stage, decreased terminal and increased miniaturized hairs were found, with variable inflammation. During recovery, increasing numbers of terminal anagen hairs from regrowth of miniaturized hairs and a lack of inflammation were noted. CONCLUSIONS The histopathologic features of alopecia areata depend on the stage of the current episode. Alopecia areata should be suspected when high percentages of telogen hairs or miniaturized hairs are present, even in the absence of a peribulbar lymphocytic infiltrate.
The two-way relationship between the Balanced Scorecard and Management Control Systems in organizations: Lessons from a Case Study

This paper reports a case study conducted in Quinta da Aveleda, one of the three largest Portuguese wine companies. Our aim was to explore the relationship established between a newly implemented Balanced Scorecard (BSc) and the elements of the Management control System (McS) in the organization. Thus, two specific objectives were pursued. Firstly, to identify the influences (barriers, opportunities) of the existing McS on the implementation of the BSc. Secondly, to identify the impacts the BSc implementation was able to exert on the configuration of the organization’s McS. We found that the budgeting process, the planning system, the information infrastructure, and the organizational structure and culture were the elements of the previous McS that influenced the BSc implementation process. eventually, the BSc implementation led to important changes in the budgeting, planning, reporting systems and processes. in order to explain these findings, we briefly explored the main issues and factors accounting for the scope and nature of the BSc’s impacts on Quinta da Aveleda. These issues and factors were the mobilized organizational resources, the implementation approach, the communication, and the organizational support.
Multimodal Imaging of Photoreceptor Structure in Choroideremia

Purpose Choroideremia is a progressive X-linked recessive dystrophy, characterized by degeneration of the retinal pigment epithelium (RPE), choroid, choriocapillaris, and photoreceptors. We examined photoreceptor structure in a series of subjects with choroideremia with particular attention to areas bordering atrophic lesions. Methods Twelve males with clinically-diagnosed choroideremia and confirmed hemizygous mutations in the CHM gene were examined. High-resolution images of the retina were obtained using spectral domain optical coherence tomography (SD-OCT) and both confocal and non-confocal split-detector adaptive optics scanning light ophthalmoscope (AOSLO) techniques. Results Eleven CHM gene mutations (3 novel) were identified; three subjects had the same mutation and one subject had two mutations. SD-OCT findings included interdigitation zone (IZ) attenuation or loss in 10/12 subjects, often in areas with intact ellipsoid zones; RPE thinning in all subjects; interlaminar bridges in the imaged areas of 10/12 subjects; and outer retinal tubulations (ORTs) in 10/12 subjects. Only split-detector AOSLO could reliably resolve cones near lesion borders, and such cones were abnormally heterogeneous in morphology, diameter and density. On split-detector imaging, the cone mosaic terminated sharply at lesion borders in 5/5 cases examined. Split-detector imaging detected remnant cone inner segments within ORTs, which were generally contiguous with a central patch of preserved retina. Conclusions Early IZ dropout and RPE thinning on SD-OCT are consistent with previously published results. Evidence of remnant cone inner segments within ORTs and the continuity of the ORTs with preserved retina suggests that these may represent an intermediate state of retinal degeneration prior to complete atrophy. Taken together, these results supports a model of choroideremia in which the RPE degenerates before photoreceptors.
Emission of terahertz radiations from fractal antennas

We investigate the emission of terahertz radiation from a photoconductive fractal antenna fabricated on a semi-insulating gallium arsenide substrate. Owing to the self-similarity of fractal structures, our fractal antenna shows a multiband emission of terahertz radiation. The emission intensity at peak frequency is about twice that from a bow-tie antenna. We also investigate the mechanism of the multiband emission by using the finite-difference time-domain calculation.
President's Cancer Panel

Over 50% of the average individual’s radiation dose comes from exposure to radon decay products. Two of the radon decay products, Polonium-218 and Polonium-214, account for the majority of the radiation exposure to the lungs. Because we are building homes without radon resistant features faster than we are mitigating homes to reduce radon concentrations, more people are exposed to radon than ever before. Furthermore, the increased use of medical procedures and tests that utilize radiation has increased substantially. The consequence of this mounting radiation exposure for an individual is genomic instability and an increased potential for cancer. In the following paper, the generic term radon will be used to refer to radon and its decay products.
Cross-domain correlation in pitch perception, the influence of native language

ABSTRACT The current study explores how language experience may shape the correlation between lexical tone and musical pitch perception. A two domains (music and lexical tone) by two languages (tone, Mandarin Chinese and non-tone, Dutch) design is adopted. Participants were tested on their discrimination of Mandarin Chinese lexical tones, Montreal Battery of Evaluation of Amusia (MBEA), and Musical Ear Test (MET). The Chinese listeners outperformed the Dutch listeners on both MBEA and MET, but had comparable accuracies for the lexical tone discrimination. Importantly, a significant cross-domain correlation was only observed for the Dutch listeners but not for the Chinese listeners. For tone language listeners, once lexical tones have been acquired, native listeners perceive them as phonological categories, and split them from other pitch variations that do not play a phonemic role. Non-tone language listeners, on the other hand, perceive both lexical tones and musical pitch on a psycho-acoustical basis, hence exhibit a unified perception of pitch across the two domains.
Sandy’s Challenge: New Game, New Paradigm

This study focuses on Sandy, an experienced physical education specialist, as she teaches STXBALL, a coeducational, noncontact, modified form of lacrosse, for the first time. Using an approach based on a workshop Sandy attended, she is teaching from a perspective that suggests game skills and tactics are linked, thus, should be taught so they emerge and play off of one another. As Sandy is challenged to think and act differently about teaching games, she begins to question and alter some of her actions, recognizing that the movement pattern of a specific skill is rarely the one that is used in a game situation. In addition, she is observing and assessing the effective use of tactics and skills as they do or do not interact.
Interleukin-10 Promoter Polymorphism is Associated with the Predisposition to the Development of IgA Nephropathy and Focal Segmental Glomerulosclerosis in Korea

The roles of interleukin-10 (IL-10) have been emphasized in several models of glomerulonephritis (GN). Three biallelic polymorphisms within the IL-10 promoter region, at positions -1,082, -819, and -592 from the transcription initiation site, were shown to affect the level of IL-10 production. To investigate the effect of IL-10 promoter polymorphisms on the predisposition to development of GN in Korea, IL-10 promoter polymorphisms were assayed by polymerase chain reaction followed by restriction fragment length polymorphism in 108 patients with IgA nephropathy (IgAN), 49 focal segmental glomerulosclerosis (FSGS), and 100 healthy controls. In comparison with the control, the frequency of -1,082*G alleles were lower in IgAN and the frequencies of -592*C and -819*C were lower in FSGS, respectively. As for the haplotype, GCC haplotype was less frequent among IgAN than the control and ATA haplotype was more frequent among FSGS than the control (p<0.05). The frequency of intermediate producer genotypes (GCC/ACC and GCC/ATA) were lower among IgAN or FSGS than the control. Our findings suggested that IL-10 promoter polymorphism predisposed to the development of IgAN and FSGS in Korean patients.
jeseh . net Identifying the Factors Affecting Science and Mathematics Achievement Using Data Mining Methods

The purpose of this article is to identify the order of significance of the variables that affect science and mathematics achievement in middle school students. For this aim, the study deals with the relationship between science and math in terms of different angles using the perspectives of multiple causes-single effect and of multiple causes-multiple effects. Furthermore, the study examines and reveals how the reading skills, problem solving skills, cognitive and affective variables influence the math and science achievement. The data was collected from the results of Turkish students who participated in three international examinations; TIMSS 1999, PISA 2003 and PISA 2006. We analyzed the data using two data-mining methods (decision trees and clustering). The findings show that science or mathematics achievement is not influenced by the course-specific variable alone but also by other related variables. The following variables are the most important; the students’ reading and problem-solving skills affected both mathematics and science achievement; the mathematics achievement affected the science achievement; and the science achievement affected the mathematics achievement. It is also found that the affective variables have almost equally significant effects on the science and mathematics achievement.
Foreign Language Anxiety in Higher Education: A Practical Framework for Reducing FLA

This study aimed at investigating foreign language anxiety level and the factors affecting the anxiety among Saudi English major students at Taif University and exploring the impact of gender and academic level in this regard. It also examined the relationship between anxiety and language proficiency in the Saudi context. Two questionnaires, a modified version of FLCAS (Horwitz et al., 1986) and IFLAF, were administered to 373 English major students (205 male and 168 female). The results revealed that Saudi English major students had moderate level of anxiety. The highest provoking causes of students' anxiety were worrying about consequences of failing, forgetting things they knew and feeling uneasiness during language tests. The analyses of the variables related to foreign language anxiety revealed a significant negative correlation between language anxiety and language proficiency (grammar, speaking, writing, reading and GPA). Gender did not have a significant impact on foreign language anxiety in the current study. Finally, the academic level of students did not affect the level of anxiety indicating that all students, despite their academic level, suffer from the same level of anxiety. The study suggested an EFL practical Model to reduce the negative effects of anxiety. Suggestions and further research were presented.
Phagocytosis of Streptococcus pyogenes by All-Trans Retinoic Acid-Differentiated HL-60 Cells: Roles of Azurophilic Granules and NADPH Oxidase

Background New experimental approaches to the study of the neutrophil phagosome and bacterial killing prompted a reassessment of the usefulness of all-trans retinoic acid (ATRA)-differentiated HL-60 cells as a neutrophil model. HL-60 cells are special in that they possess azurophilic granules while lacking the specific granules with their associated oxidase components. The resulting inability to mount an effective intracellular respiratory burst makes these cells more dependent on other mechanisms when killing internalized bacteria. Methodology/Principal Findings In this work phagocytosis and phagosome-related responses of ATRA-differentiated HL-60 cells were compared to those earlier described in human neutrophils. We show that intracellular survival of wild-type S. pyogenes bacteria in HL-60 cells is accompanied by inhibition of azurophilic granule–phagosome fusion. A mutant S. pyogenes bacterium, deficient in M-protein expression, is, on the other hand, rapidly killed in phagosomes that avidly fuse with azurophilic granules. Conclusions/Significance The current data extend our previous findings by showing that a system lacking in oxidase involvement also indicates a link between inhibition of azurophilic granule fusion and the intraphagosomal fate of S. pyogenes bacteria. We propose that differentiated HL-60 cells can be a useful tool to study certain aspects of neutrophil phagosome maturation, such as azurophilic granule fusion.
Multi-robot 6D graph SLAM connecting decoupled local reference filters

Teams of mobile robots can be deployed in search and rescue missions to explore previously unknown environments. Methods for joint localization and mapping constitute the basis for (semi-)autonomous cooperative action, in particular when navigating in GPS-denied areas. As communication losses may occur, a decentralized solution is required. With these challenges in mind, we designed a submap-based SLAM system that relies on inertial measurements and stereo-vision to create multi-robot dense 3D maps. For online pose and map estimation, we integrate the results of keyframe-based local reference filters through incremental graph SLAM. To the best of our knowledge, we are the first to combine these two methods to benefit from their particular advantages for 6D multi-robot localization and mapping: Local reference filters on each robot provide real-time, long-term stable state estimates that are required for stabilization, control and fast obstacle avoidance, whereas online graph optimization provides global multi-robot pose and map estimates needed for cooperative planning. We propose a novel graph topology for a decoupled integration of local filter estimates from multiple robots into a SLAM graph according to the filters' uncertainty estimates and independence assumptions and evaluated its benefits on two different robots in indoor, outdoor and mixed scenarios. Further, we performed two extended experiments in a multi-robot setup to evaluate the full SLAM system, including visual robot detections and submap matches as inter-robot loop closure constraints.
The Effectiveness of Using a Content Acquisition Podcast to Teach Phonological Awareness, Phonemic Awareness, and Phonics to Preservice Special Education Teachers

The purpose of this study was to examine the effects of using a content acquisition podcast (CAP) to teach phonological awareness, phonemic awareness, and phonics (PA) to preservice special education teachers. Fifty undergraduate preservice special education teachers over 2 years were randomly assigned to either the CAP group or a comparison group during a semester-long course on language development. The CAP group watched a 10-min CAP on PA, and the comparison group read a practitioner-friendly article. As part of the course, both groups were instructed to complete a required textbook chapter reading before class and received an expert guest lecture on these topics following the experimental conditions. There were no pretest differences between groups, years, or between students who completed the required textbook reading and those who did not. Results indicated that the CAP group significantly outperformed the comparison group on declarative knowledge and application items in PA and grew in their learning at a faster rate. CAPs offer an effective and efficient method for teaching PA and, in this study, were more effective at teaching PA and at helping students apply that knowledge than reading alone.
In Vitro Structural Changes of Nano-Bacterial Cellulose Immersed in Phosphate Buffer Solution

Nano-bacterial cellulose (nBC), secreted by Acetobacter xylinum, is expected to have potential applications in tissue engineering. In this paper, the in-vitro degradation performance and the corresponding mechanism of nBC immersed in phosphate buffer solution (PBS) for different time periods was investigated. The pH value variation of solution, material degradation, and the swelling and structural changes of nBC was analysed successively. The results indicate that water molecules attack the exposed nBC fibrils, weakening the bonding strength of inter- and intra-molecular chains and disconnecting partial C-O-C bonds. The disconnection of C-O-C bonds is considered the primary reason for the degradation of nBC large molecular chains after nBC is immersed in PBS. The present work is instructive for controlling the in-vivo degradation performance of nBC acting as bone tissue engineered scaffold materials.