Miracle-dz/UniFAR-FTUs huggingface dataset:
Prayer, purpose in life, and attitudes toward substances: a study among 13- to 15-year-olds in England and Wales

This study set out to examine the association between prayer frequency, purpose in life and attitude toward substances, among a sample of 2,563 13- to 15-year-old secondary school pupils in England and Wales. Multivariate models controlling for sex, school year and personality (as defined by the Eysenkian dimensional model) demonstrated that higher levels of purpose in life are associated with greater prayer frequency, and that more proscriptive attitudes toward substances are associated with both higher levels of purpose in life and greater prayer frequency. These findings are consistent with a model suggesting that prayer frequency promotes a more negative view of substances both directly and indirectly through cultivating a greater sense of purpose in life.
Students' Sense of Belonging in Technical/Vocational Schools versus Academic Schools: The Mediating Role of Faculty Trust in Students.

Background: Since the late 1960s, research has demonstrated repeatedly that students in lower tracks achieve less as they develop an antischool culture to overcome the status deprivation resulting from being in a lower track. In quantitative large-scale research, this antischool culture is usually assessed using poor academic attitudes or study disengagement because antischool norms disengage students from the learning process. The extent to which students in different tracks feel embedded in their school communities—their sense of school belonging—has rarely been examined, although academic engagement and sense of belonging are related to each other and to achievement. Objective: This article examines students’ sense of belonging in secondary schools that offer different tracks, and the role played by the faculty’s trust in the students. Participants: The study is based on data from 3,475 students and 754 teachers in 28 technical/vocational schools and 3,376 students and 461 teachers in 22 academic schools in Flanders, the northern, Dutch-speaking part of Belgium. Research Design: Use is made of (stepwise) multilevel analyses (HLM6). Results: The analyses show that students in technical/vocational schools have a significant lower sense of belonging than students in academic schools. This association disappears if we take into account faculty trust in students. The association between school type and perceived teacher support, a subdimension of the sense of belonging, is not mediated by faculty trust, but is due to the lower GPA of students in technical/vocational schools. Conclusions: The results indicate that teachers play a crucial role in the divergent nature of students’ social integration across different types of schools. In terms of strengthening students’ connectedness to a technical/vocational school environment, our results indicate that strengthening teachers’ level of trust in students could be crucial.
Correction of anaemia of chronic renal failure with recombinant human erythropoietin: safety and efficacy of one year's treatment in a European multicentre study of 150 haemodialysis-dependent patients.

One hundred and fifty patients undergoing regular haemodialysis for end-stage renal failure entered a trial of treatment for anaemia with recombinant human erythropoietin (r-HuEPO). At data cut-off 37 patients (24.6%) had dropped out for various reasons; most of them (n = 22) discontinued because of kidney transplantation (after 3-17 months of treatment). The initial dose was 24 U/kg i.v. thrice weekly, with subsequent dose escalations after a minimum of 2 weeks if the haemoglobin (Hb) was less than 10% above the pretreatment baseline. One hundred and forty-three patients who were eligible for efficacy analysis achieved an Hb increase of greater than or equal to 2 g/dl, and all 139 patients eligible for 'full response' analysis (Hb between 10 and 12 g/dl) were dose titrated to reach this arbitrarily defined optimal range. Patients' response to r-HuEPO treatment was independent of age, weight, nephric state or duration of dialysis treatment. To maintain the Hb within the range of 10-12 g/dl during 1 year's treatment (n = 96) a median weekly r-HuEPO dose of 200 U/kg (range 150-300) divided into one, two, or three administrations appeared to be adequate. This maintenance dose depends slightly on the patient's baseline Hb. The study provides evidence that long-term treatment with r-HuEPO is safe. In 48 patients (of whom 12 had no history of hypertension) elevation of blood pressure required additional treatment, which was effective in all but one who was withdrawn from the study. Four patients had seizures and one suffered hypertensive encephalopathy without convulsions. (ABSTRACT TRUNCATED AT 250 WORDS)
A study on risk of twin pregnancy

Introduction: Twin pregnancy is associated with more pregnancy complications and poorer pregnancy outcome than singleton pregnancy. Aim: To evaluate the maternal and fetal complications in twin pregnancies. Materials and methods: 300 Twin Pregnancies were studied over a period of 16 months from 200607 to evaluate complications to the mother and both fetuses. Data obtained at the time of delivery included maternal age, parity, gestational age at the time of delivery, mode of delivery and fetal weights. Results: Among 25754 deliveries in 16 months we had 300 twin pregnancies, incidence being 1:85. Incidence of twins in percentage was 1.16%. Majority of women were in the age group of 20-25 years and majority of women gestational age 2832 weeks. Almost half of the twin pregnancies were unbooked cases. Out of the twin deliveries 50.3% were unbooked cases where as 49.6% were booked cases. Ratio of Primigravidae and multigravidae was 2.4:1 respectively. The most frequent maternal complication was pregnancy induced hypertension which occurred in 39.3% of cases. Other common complications encountered were premature rupture of membranes (10%) and anemia (6.3%). The commonest fetal complication was preterm labour accounting in 130 (43.3%) cases and with malpresentations in 87 (29%) cases followed by severe discordancy in 26 (12.4%). The highest perinatal mortality rate was 28/97 in low birth weight group i.e., 1-1.5 kg and high survival rate was seen in >2.5 kg body weight children. Conclusion: Twin pregnancies are significant risk factor for maternal and fetal complications include pregnancy induced hypertension and prematurity respectively.
Improving Guidance when Restructuring Variabilities in Software Product Lines

Software Product Lines (SPLs) encompass a family of software systems developed from reusable assets. One issue during SPL maintenance is the decision about which mechanism should be used to restructure variabilities aiming at improving the modularity of the SPL artifacts. Due to the great variety of mechanisms (Inheritance, Configuration Files, Aspect-Oriented Programming), selecting the incorrect ones may produce negative effects on the cost to evolve the SPL. To reduce this problem, we propose a decision model to help developers to choose mechanisms to restructure variabilities in SPLs. The domain analyzed by this work consists of test scripts. We also developed a prototype tool to support developers by recommending mechanisms according to the decision model. Using our model and tool may improve the tests variabilities’ modularity and remove bad smells such as cloned code.
Effect of treating allergic rhinitis with corticosteroids in patients with mild-to-moderate persistent asthma.

STUDY OBJECTIVES Rhinitis and asthma are considered to be synchronic or sequential forms of the same allergic syndrome. Treating the inflammation associated with allergic rhinitis influences the control of asthma. However, few studies have investigated the effect of treating perennial rhinitis on persistent asthma and vice versa. We determined the effects of inhaled or topical nasal beclomethasone dipropionate (BDP) administered separately or in combination on the control of asthma and bronchial hyperresponsiveness (BHR) in patients with the rhinitis/asthma association. DESIGN A double-blind, parallel, three-group study. SETTING Outpatient clinic of Pulmonary Division/Heart Institute (InCor) and the Division of General Internal Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil. PATIENTS Seventy-four patients with mild-to-moderate asthma and allergic rhinitis (median age, 25 years). INTERVENTIONS Patients received nasal or inhaled BDP separately or in combination for 16 weeks after a 2-week placebo run-in period. MEASUREMENTS AND RESULTS Nasal and pulmonary symptoms, as well as pulmonary function and BHR, were compared among the three groups after 4 weeks and 16 weeks of treatment. Patients in all three groups demonstrated a progressive and significant decrease in nasal and pulmonary symptoms, which started after 4 weeks (p < 0.05) and continued through the end of treatment (p < 0.001). Clinical improvement was similar and parallel in the three groups. Asthma-related morbidity, evaluated by quantifying absence from work, emergency department visits, and nighttime awakenings, also decreased in the three groups (p < 0.05). CONCLUSIONS Failure to consider treatment of rhinitis as essential to asthma management might impair clinical control of asthma. Furthermore, these data suggest that asthma and rhinitis in some patients can be controlled by the exclusive use of nasal medication.
Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction.

BACKGROUND Estradiol (E2) modulates the kinetics of circulating endothelial progenitor cells (EPCs) and favorably affects neovascularization after ischemic injury. However, the roles of estrogen receptors alpha (ER alpha) and beta (ER beta) in EPC biology are largely unknown. METHODS AND RESULTS In response to E2, migration, tube formation, adhesion, and estrogen-responsive element-dependent gene transcription activities were severely impaired in EPCs obtained from ER alpha-knockout mice (ER alphaKO) and moderately impaired in ER betaKO EPCs. The number of ER alphaKO EPCs (42.4+/-1.5; P<0.001) and ER betaKO EPCs (55.4+/-1.8; P=0.03) incorporated into the ischemic border zone was reduced as compared with wild-type (WT) EPCs (72.5+/-1.3). In bone marrow transplantation (BMT) models, the number of mobilized endogenous EPCs in E2-treated mice was significantly reduced in ER alphaKO BMT (WT mice transplanted with ER alphaKO bone marrow) (2.03+/-0.18%; P=0.004 versus WT BMT) and ER betaKO BMT (2.62+/-0.07%; P=0.02 versus WT) compared with WT BMT (2.87+/-0.13%) (WT to WT BMT as control) mice. Capillary density at the border zone of ischemic myocardium also was significantly reduced in ER alphaKO BMT and ER betaKO BMT compared with WT mice (WT BMT, 1718+/-75/mm2; ER alphaKO BMT, 1107+/-48/mm2; ER betaKO BMT, 1567+/-50/mm2). ER alpha mRNA was expressed more abundantly on EPCs compared with ER beta. Moreover, vascular endothelial growth factor was significantly downregulated on ER alphaKO EPCs compared with WT EPCs both in vitro and in vivo. CONCLUSIONS Both ER alpha and ER beta contribute to E2-mediated EPC activation and tissue incorporation and to preservation of cardiac function after myocardial infarction. ER alpha plays a more prominent role in this process. Moreover, ER alpha contributes to upregulation of vascular endothelial growth factor, revealing possible mechanisms of an effect of E2 on EPC biology. Finally, these data provide additional evidence of the importance of bone marrow-derived EPC phenotype in ischemic tissue repair.
Deep Self-Taught Learning for Handwritten Character Recognition

Recent theoretical and empirical work in statistical machine learning has demonstrated the importance of learning algorithms for deep architectures, i.e., function classes obtained by composing multiple non-linear transformations. Self-taught learning (exploiting unlabeled examples or examples from other distributions) has already been applied to deep learners, but mostly to show the advantage of unlabeled examples. Here we explore the advantage brought by out-of-distribution examples. For this purpose we developed a powerful generator of stochastic variations and noise processes for character images, including not only affine transformations but also slant, local elastic deformations, changes in thickness, background images, grey level changes, contrast, occlusion, and various types of noise. The out-of-distribution examples are obtained from these highly distorted images or by including examples of object classes different from those in the target test set. We show that deep learners benefit more from out-of-distribution examples than a corresponding shallow learner, at least in the area of handwritten character recognition. In fact, we show that they beat previously published results and reach human-level performance on both handwritten digit classification and 62-class handwritten character recognition.
Overexpression of periostin predicts poor prognosis in non-small cell lung cancer

The periostin protein, encoded by the POSTN gene, is a component of the extracellular matrix, which is expressed by fibroblasts and has been observed in a variety of human malignancies. The present study aimed to detect the expression of periostin in the tissues of non-small cell lung cancer (NSCLC) patients and benign lung tumors, and to correlate the results with the clinicopathological data of the subjects, in order to evaluate periostin as a potential prognostic marker. In total, 49 NSCLC patients and 6 benign lung tumors were included in this study. The protein level of periostin was detected in paired normal/paratumor/cancer tissues by a western blot analysis and the mRNA level in paired normal/cancer tissues was detected by quantitative polymerase chain reaction (qPCR). The results were then correlated with established biological and prognostic factors. Immunohistochemistry was used to confirm the location of periostin in the NSCLC tissues. Uni- and multivariate analyses were performed using Cox’s proportional hazards regression model. The protein level of periostin was elevated in the cancer tissue of the NSCLC patients compared with the normal (P=0.017) and paratumor (P=0.000) tissues. The expression level in the male patients was much higher than in the female patients at the protein (P=0.001) and mRNA (P=0.010) levels. The mRNA level in the non-adenocarcinoma (non-ADC) patients was much higher than in the adenocarcinoma (ADC) patients (P=0.029). Periostin was demonstrated higher expression at the protein level in the pseudotumors and tuberculosis patients than in the adjacent (P=0.016) and surrounding tissues (P=0.001). Immunostaining indicated that high levels of periostin were present in the mesenchymal areas, but not in the cancer cells themselves. The patients with tumors exhibiting high-level periostin expression showed a significantly shorter survival time (P=0.036, log-rank test). The 3-year survival rate was 81.5% for patients with low-level periostin expression (periostin-L; n=27) and 45.4% for patients with high-level periostin expression (periostin-H; n=22). Similarly, pathological node (pN) status was a significant prognostic marker in the univariate Cox survival analysis. Notably, periostin-H expression was also identified as an independent prognostic factor by the multivariate analysis (P=0.011). These results showed that the overexpression of periostin predicts a poor prognosis, therefore it may be regarded as a novel molecule in the progression and development of NSCLC. The results provide an additional target for the adjuvant treatment of NSCLC.
Metabolomic patterns associated to QTc interval in shiftworkers: an explorative analysis

Abstract Objectives: 1H NMR-metabolomic approach was used to investigate QTc interval correlation with plasma metabolic profiles in shiftworkers. Methods: Socio-demographic data, electrocardiographic QTc interval and plasma metabolic profiles from 32 male shiftworkers, were correlated by multivariate regression analysis. Results: We found a positive correlation between QTc interval values, body mass index, glycemia and lactate level and a negative correlation between QTc interval and both pyroglutamate and 3-hydroxybutyrate plasma level. Conclusions: Our analysis provides evidence of the association between clinical, metabolic profiles and QTc interval values. This could be used to identify markers of early effects and/or susceptibility in shiftworkers.
Does the mean adequately represent reading performance? Evidence from a cross-linguistic study

Reading models are largely based on the interpretation of average data from normal or impaired readers, mainly drawn from English-speaking individuals. In the present study we evaluated the possible contribution of orthographic consistency in generating individual differences in reading behavior. We compared the reading performance of young adults speaking English (one of the most irregular orthographies) and Italian (a very regular orthography). In the 1st experiment we presented 22 English and 30 Italian readers with 5-letter words using the Rapid Serial Visual Presentation (RSVP) paradigm. In a 2nd experiment, we evaluated a new group of 26 English and 32 Italian proficient readers through the RSVP procedure and lists matched in the two languages for both number of phonemes and letters. The results of the two experiments indicate that English participants read at a similar rate but with much greater individual differences than the Italian participants. In a 3rd experiment, we extended these results to a vocal reaction time (vRT) task, examining the effect of word frequency. An ex-Gaussian distribution analysis revealed differences between languages in the size of the exponential parameter (tau) and in the variance (sigma), but not the mean, of the Gaussian component. Notably, English readers were more variable for both tau and sigma than Italian readers. The pattern of performance in English individuals runs counter to models of performance in timed tasks (Faust et al., 1999; Myerson et al., 2003) which envisage a general relationship between mean performance and variability; indeed, this relationship does not hold in the case of the English participants. The present data highlight the importance of developing reading models that not only capture mean level performance, but also variability across individuals, especially in order to account for cross-linguistic differences in reading behavior.
Thrombolysis in Young Adults With Ischemic Stroke

Background and Purpose— No exclusive systematic data exist on the safety and outcomes of thrombolytic treatment in young patients with ischemic stroke. Methods— We evaluated all 48 patients aged 16 to 49 years with hemispheric ischemic stroke treated with intravenous alteplase in Helsinki University Central Hospital from 1994 to 2007. For comparison of outcome, we selected, blinded to outcome data, 96 control subjects (1:2) with ischemic stroke not treated with alteplase matched by age, gender, and admission stroke severity (National Institutes of Health Stroke Scale). We selected similarly 96 older alteplase-treated gender and arrival National Institutes of Health Stroke Scale score-matched patients (aged, 50 to 79 years) for comparison of outcome and hemorrhage rate. A 3-month favorable outcome was defined as modified Rankin Scale score of 0 to 1. Symptomatic intracerebral hemorrhage was defined according to the Safe Implementation of Thrombolysis in Stroke Monitor Study. Results— Young alteplase-treated patients (67% males; mean age, 38.8±9.1 years) more often recovered completely (27% versus 10%, P=0.010) and achieved a favorable outcome (40% versus 22%, P=0.025) compared with their age-matched control subjects not treated with alteplase. In alteplase-treated patients, unfavorable outcome was more frequent in males and in those with carotid artery dissection. We observed no difference in outcome between cases and older control subjects treated with alteplase. However, none of the cases had symptomatic intracerebral hemorrhage versus 3 (3%) in the older control group (P=0.551). Mortality rate was 2% (P=0.552) in age-matched control subjects and 7% (P=0.095) among older control subjects, whereas none of the case patients died during the 3-month follow-up. Conclusions— Young adults with acute hemispheric ischemic stroke benefited from intravenous thrombolysis with good safety.
Examinee Issues in CAT.

The perspective of the examinee during the administration of a computerized adaptive test (CAT) is discussed, focusing on issues of test development. Item review is the first issue discussed. Virtually no CATs provide the opportunity for the examinee to go back and review, and possibly change, answers. There are arguments on either side of the item review issue, and test givers should weigh them carefully, considering examinee anxiety and performance factors. Another issue is that of time limits, which have little benefit for test takers, but serve only the interests of test givers. CAT developers should consider very liberal time limits or none at all, especially since a CAT is shorter than its conventional testing counterparts. Test anxiety may be increased in a CAT environment, and test developers should be aware of the potential for anxiety among examinees. Another issue is that of examinee motivation. CAT developers should be aware of the effects of test consequences on test performance to ensure that data used to calibrate item banks are collected under conditions that have the same consequences as the operational test. Equity is an important issue in CAT, since some examinees will have less computer experience than others. Each of these issues has implications for the validity of inferences made from CAT scores and should be considered when CATs are used. (Contains 27 references.) (SLD) ******************************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. ******************************************************************************** U.S. DEPARTMENT OF EDUCATION Office of Educational Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) This document has been reproduced as received from the person or organization originating it. Minor changes have been made to improve reproduction quality. Points of view or opinions stated in this document do not necessarily represent official OERI position or policy. N 00 O PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY
Surgical treatment of 125 patients with non-small cell lung cancer and chest wall involvement.

BACKGROUND: The optimum operative procedure for lung cancer with chest wall invasion (T3) remains controversial. In this study results of en bloc resection and extrapleural dissection are reviewed to determine survival characteristics. METHODS: Between 1977 and 1993 125 patients underwent surgery for primary non-small cell lung cancer with chest wall invasion. Patients with superior sulcus tumours, metastatic carcinomas, synchronous tumours, or recurrences were excluded. Extrapleural dissection was performed in 73 patients and en bloc resection (range 1-4 ribs) in 52. Resection was regarded as complete in 86 and incomplete in 39 patients. Actuarial survival time was estimated and risk factors for late death were identified. RESULTS: Hospital mortality was 3.2%. (n = 4). Estimated mean five year survival was 24% for all hospital survivors (n = 121), 11% for patients with incomplete resection, and 29% for patients having a complete resection. In patients who underwent complete resection mediastinal lymph node involvement and intrapleural tumour spill worsened the prognosis. Patients with adenocarcinoma had a better chance of long term survival. No relationship was found between survival and age, type of operative procedure, depth of chest wall invasion, and postoperative radiotherapy. CONCLUSIONS: Both operative procedures show reasonable survival results. Incomplete resection, mediastinal lymph node involvement, and intrapleural tumour spill adversely influence survival.