Miracle-dz/UniFAR-FTUs huggingface dataset:
Quignard PART 1 Second and Third Generation Biofuels : Towards Sustainability and Competitiveness Deuxième et troisième génération de biocarburants : développement durable et compétitivité

Membrane Fractionation of Biomass Fast Pyrolysis Oil and Impact of its Presence on a Petroleum Gas Oil Hydrotreatment— In order to limit the greenhouse effect causing climate change and reduce the needs of the transport sector for petroleum oils, transformation of lignocellulosic biomass is a promising alternative route to produce automotive fuels, chemical intermediates and energy. Gasification and liquefaction of biomass resources are the two main routes that are under investigation to convert biomass into biofuels. In the case of the liquefaction, due to the unstability of the liquefied products, one solution can be to perform a specific hydrotreatment of fast pyrolysis bio-oils with petroleum cuts in existing petroleum refinery system. With this objective, previous studies [Pinheiro et al. (2009) Energy Fuels 23, 1007-1014; Pinheiro et al. (2011) Energy Fuels 25, 804-812] have been carried out to investigate the impact of oxygenated model compounds on a Straight Run Gas Oil (SRGO) hydrotreatment using a CoMo catalyst. The authors have demonstrated that the main inhibiting effects are induced from CO and CO2 produced during hydrodeoxygenation of esters and carboxylic acids. To go further, cotreatment of a fast pyrolysis oil with the same SRGO as used in the previous studies was investigated in this present work. Firstly the bio-oil was separated into four fractions by membrane fractionation using 400 and 220 Da molecular weight cut-off membranes. The bio-oil and its fractions were analyzed by spectroscopic and chromatographic techniques. Then, one fraction (i.e. fraction enriched in compounds with molecular weight from 220 to 400 Da) was mixed with the SRGO and co-treated. Despite some experimental difficulties mainly due to the emulsion instability, the hydrotreatment was successful. An inhibition has been observed on the hydrotreating reactions of the SRGO in presence of the bio-oil fraction. The measurement of the CO/CO2/CH4 molar flowrate at the reactor outlet showed that the inhibition was due to the presence of CO and CO2 coming from HDO rather than to the oxygen compounds themselves.
Large Diversity of Nonstandard Genes and Dynamic Evolution of Chloroplast Genomes in Siphonous Green Algae (Bryopsidales, Chlorophyta)

Abstract Chloroplast genomes have undergone tremendous alterations through the evolutionary history of the green algae (Chloroplastida). This study focuses on the evolution of chloroplast genomes in the siphonous green algae (order Bryopsidales). We present five new chloroplast genomes, which along with existing sequences, yield a data set representing all but one families of the order. Using comparative phylogenetic methods, we investigated the evolutionary dynamics of genomic features in the order. Our results show extensive variation in chloroplast genome architecture and intron content. Variation in genome size is accounted for by the amount of intergenic space and freestanding open reading frames that do not show significant homology to standard plastid genes. We show the diversity of these nonstandard genes based on their conserved protein domains, which are often associated with mobile functions (reverse transcriptase/intron maturase, integrases, phage- or plasmid-DNA primases, transposases, integrases, ligases). Investigation of the introns showed proliferation of group II introns in the early evolution of the order and their subsequent loss in the core Halimedineae, possibly through RT-mediated intron loss.
Coordination of Large Pulsed Loads on Future Electric Ships

Part of the technical versatility of future all-electric ships is the potential ability to share large amounts of power among a variety of high-power loads. To help evaluate this potential and to provide information to help guide technology selection, a physics-based model of a power train for an electric ship has been developed and implemented on three modeling platforms. Using this model, three different investigations have been carried out to explore aspects of the behavior of a rotating machine power source for a shipboard rail launcher. These were: 1) influence of rapid charging of the rotating machine system on the ship power system; 2) use of the stored energy in the rotating machines to improve ship power quality; and 3) use of the stored energy in the rotating machines to power a pulsed free-electron laser. Each study highlighted different integration opportunities and challenges. The first showed that, because the charging of the rail launchers was through 5-MW motors, there could be a voltage sag for a few cycles, but this could easily be managed so that the sag could be reduced to an inconsequential level. The second study showed that, with appropriate power electronics, the stored energy in the rail launcher power supply can be used to correct power quality problems introduced by other ship systems. Finally, the stored energy in the launcher power supply can be used to fire a free electron laser for ship defense. This feature opens the possibility of routine operation of the entire ship at highest efficiency, i.e., with the smallest number of gas turbines operating near full power, while providing stored energy needed for ship defense
Chirality Matters: Synthesis and Consumption of the d-Enantiomer of Lactic Acid by Synechocystis sp. Strain PCC6803

ABSTRACT Both enantiomers of lactic acid, l-lactic acid and d-lactic acid, can be produced in a sustainable way by a photosynthetic microbial cell factory and thus from CO2, sunlight, and water. Several properties of polylactic acid (a polyester of polymerized lactic acid) depend on the controlled blend of these two enantiomers. Recently, cyanobacterium Synechocystis sp. strain PCC6803 was genetically modified to allow formation of either of these two enantiomers. This report elaborates on the d-lactic acid production achieved by the introduction of a d-specific lactate dehydrogenase from the lactic acid bacterium Leuconostoc mesenteroides into Synechocystis. A typical batch culture of this recombinant strain initially shows lactic acid production, followed by a phase of lactic acid consumption, until production “outcompetes” consumption at later growth stages. We show that Synechocystis is able to use d-lactic acid, but not l-lactic acid, as a carbon source for growth. Deletion of the organism's putative d-lactate dehydrogenase (encoded by slr1556), however, does not eliminate this ability with respect to d-lactic acid consumption. In contrast, d-lactic acid consumption does depend on the presence of glycolate dehydrogenase GlcD1 (encoded by sll0404). Accordingly, this report highlights the need to match a product of interest of a cyanobacterial cell factory with the metabolic network present in the host used for its synthesis and emphasizes the need to understand the physiology of the production host in detail.
Development of a Multi-Spatial Resolution Approach to the Surveillance of Active Fire Lines Using Himawari-8

Satellite remote sensing is regularly used for wildfire detection, fire severity mapping and burnt area mapping. Applications in the surveillance of wildfire using geostationary-based sensors have been limited by low spatial resolutions. With the launch in 2015 of the AHI (Advanced Himawari Imaginer) sensor on board Himawari-8, ten-minute interval imagery is available covering an entire earth hemisphere across East Asia and Australasia. Existing active fire detection algorithms depend on middle infrared (MIR) and thermal infrared (TIR) channels to detect fire. Even though sub-pixel fire detection algorithms can detect much smaller fires, the location of the fire within the AHI 2 × 2 km (400 ha) MIR/TIR pixel is unknown. This limits the application of AHI as a wildfire surveillance and tracking sensor. A new multi-spatial resolution approach is presented in this paper that utilizes the available medium resolution channels in AHI. The proposed algorithm is able to map firelines at a 500 m resolution. This is achieved using near infrared (NIR) (1 km) and RED (500 m) data to detect burnt area and smoke within the flagged MIR (2 km) pixel. Initial results based on three case studies carried out in Western Australia shows that the algorithm was able to continuously track fires during the day at 500 m resolution. The results also demonstrate the utility for wildfire management activities.
In vivo characterization of bivalve larval shells: a confocal Raman microscopy study

In vivo confocal Raman microscopy (CRM), polarized light microscopy and Fourier transform infrared spectroscopy (FTIR) were used to determine if a significant amount of amorphous calcium carbonate (ACC) exists within larval shells of Baltic mytilid mussels (Mytilus edulis-like) and whether the amount of ACC varies during larval development. No evidence for ACC was found from the onset of shell deposition at 21 h post-fertilization (hpf) until 48 hpf. Larval Mytilus shells were crystalline from 21 hpf onwards and exhibited CRM and FTIR peaks characteristic of aragonite. Prior to shell deposition at 21 hpf, no evidence for carbonates was observed through in vivo CRM. We further analysed the composition of larval shells in three other bivalve species, Mercenaria mercenaria, Crassostrea gigas and Crassostrea virginica and observed no evidence for ACC, which is in contrast to previous work on the same species. Our findings indicate that larval bivalve shells are composed of crystalline aragonite and we demonstrate that conflicting results are related to sub-optimal measurements and misinterpretation of CRM spectra. Our results demonstrate that the common perception that ACC generally occurs as a stable and abundant precursor during larval bivalve calcification needs to be critically reviewed.
A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals

Background: In HIV infection, lymphoid tissue is disrupted by fibrosis. Angiotensin converting enzyme inhibitors have anti-fibrotic properties. We completed a pilot study to assess whether the addition of lisinopril to antiretroviral therapy (ART) reverses fibrosis of gut tissue, and whether this leads to reduction of HIV RNA and DNA levels. Methods: Thirty HIV-infected individuals on ART were randomized to lisinopril at 20mg daily or matching placebo for 24 weeks. All participants underwent rectal biopsies prior to starting the study drug and at 22 weeks, and there were regular blood draws. The primary end point was the change in HIV RNA and DNA levels in rectal tissue. Secondary outcomes included the change in 1) HIV levels in blood; 2) Gag-specific T-cell responses; 3) levels of T-cell activation; and 4) collagen deposition. Results: The addition of lisinopril did not have a significant effect on the levels of HIV RNA or DNA in gut tissue or blood, Gag-specific responses, or levels of T-cell activation. Lisinopril also did not have a significant impact on lymphoid fibrosis in the rectum, as assessed by quantitative histology or heavy water labeling. Conclusions: Treatment with lisinopril for 24 weeks in HIV-infected adults did not have an effect on lymphoid fibrosis, immune activation, or gut tissue viral reservoirs. Further study is needed to see if other anti-fibrotic agents may be useful in reversing lymphoid fibrosis and reducing HIV levels. Clinical Trials Registration: NCT01535235
NEUROCOGNITIVE THEORY AND CONSTRUCTIVISM IN SCIENCE EDUCATION : A REVIEW OF NEUROBIOLOGICAL , COGNITIVE AND CULTURAL PERSPECTIVES

A review of current thought in science education, especially constructivist perspectives, emphasizing cognitive and neuroscientific theory and research is presented with particular attention to teaching and learning science. A brief historical perspective on antecedent theories that emerged during the latter half of the twentieth century is presented as a context for integrating a neurocognitive model of information processing with modern perspectives on how students think and learn scientific ideas and ways of knowing through inquiry. A neurocognitive model is presented, rationalized in terms of current evidence and finally applied to explain, and hopefully enhance, how science can be taught more effectively using current inquiry approaches. Recommendations are made for curriculum design, improving inquiry practices, enhancing scientific thinking, and future research.
A stretched conformation of DNA with a biological role?

Abstract We have discovered a well-defined extended conformation of double-stranded DNA, which we call Σ-DNA, using laser-tweezers force-spectroscopy experiments. At a transition force corresponding to free energy change ΔG = 1·57 ± 0·12 kcal (mol base pair)−1 60 or 122 base-pair long synthetic GC-rich sequences, when pulled by the 3′−3′ strands, undergo a sharp transition to the 1·52 ± 0·04 times longer Σ-DNA. Intriguingly, the same degree of extension is also found in DNA complexes with recombinase proteins, such as bacterial RecA and eukaryotic Rad51. Despite vital importance to all biological organisms for survival, genome maintenance and evolution, the recombination reaction is not yet understood at atomic level. We here propose that the structural distortion represented by Σ-DNA, which is thus physically inherent to the nucleic acid, is related to how recombination proteins mediate recognition of sequence homology and execute strand exchange. Our hypothesis is that a homogeneously stretched DNA undergoes a ‘disproportionation’ into an inhomogeneous Σ-form consisting of triplets of locally B-like perpendicularly stacked bases. This structure may ensure improved fidelity of base-pair recognition and promote rejection in case of mismatch during homologous recombination reaction. Because a triplet is the length of a gene codon, we speculate that the structural physics of nucleic acids may have biased the evolution of recombinase proteins to exploit triplet base stacks and also the genetic code.
Challenges of Quantified-Self: Encouraging Self-Reported Data Logging During Recurrent Smartphone Usage

We argue that improved data entry can motivate Quantified-Self (QS) users to better engage with QS applications. To improve data entry, we investigate the notion of transforming active smartphone usage into data logging contributions through alert dialogs. We evaluate this assertion in a 4-week long deployment with 48 participants. We collect 17,906 data entries, where 68.3% of the entries are reported using the alert dialogs. We demonstrate that QS applications can benefit from alert dialogs: to increase data precision, frequency, and reduce the probability of forgetfulness in data logging. We investigate the impact of usage session type ( e.g., sessions with different goals or durations) and the assigned reminder delay on frequency of data contributions. We conclude with insights gathered from our investigation, and the implications they have on future designs.
Recent advances in diagnosing cutaneous melanomas

Early detection of lesions while minimising the unnecessary removal of benign lesions is the clinical aim in melanoma diagnosis. In this context, several non-invasive diagnostic modalities, such as dermoscopy, total body photography, and reflectance confocal microscopy have emerged in recent years aiming at increasing diagnostic accuracy. The main developments in this field are the integration of dermoscopy and digital photography into clinical practice.
Diversity, Productivity, and Stability of an Industrial Microbial Ecosystem

ABSTRACT Managing ecosystems to maintain biodiversity may be one approach to ensuring their dynamic stability, productivity, and delivery of vital services. The applicability of this approach to industrial ecosystems that harness the metabolic activities of microbes has been proposed but has never been tested at relevant scales. We used a tag-sequencing approach with bacterial small subunit rRNA (16S) genes and eukaryotic internal transcribed spacer 2 (ITS2) to measuring the taxonomic composition and diversity of bacteria and eukaryotes in an open pond managed for bioenergy production by microalgae over a year. Periods of high eukaryotic diversity were associated with high and more-stable biomass productivity. In addition, bacterial diversity and eukaryotic diversity were inversely correlated over time, possibly due to their opposite responses to temperature. The results indicate that maintaining diverse communities may be essential to engineering stable and productive bioenergy ecosystems using microorganisms.
On the DoF of Two-way 2×2×2 Relay Networks with or without Relay Caching

Two-way relay is potentially an effective approach to spectrum sharing and aggregation by allowing simultaneous bidirectional transmissions between source–destinations pairs. In this study, the two-way 2 × 2 × 2 relay network, a class of four-unicast networks, where there are four source/destination nodes and two relay nodes, with each source sending a message to its destination, is studied. They show that without relay caching the total degrees of freedom (DoF) is bounded from above by 8 / 3 , indicating that bidirectional links do not double the DoF (it is known that the total DoF of one-way 2 × 2 × 2 relay network is 2). Further, they show that the DoF of 8 / 3 is achievable for the two-way 2 × 2 × 2 relay network with relay caching. Finally, even though the DoF of this network is no more than 8 / 3 for generic channel gains, DoF of 4 can be achieved for a symmetric configuration of channel gains.
Is There a Global Liquidity Factor?

This paper investigates commonalities in liquidity and their implications for the pricing of financial assets in an international framework. It shows that three different monthly measures of individual stock liquidity exhibit commonalities within and across countries for a sample from Japan, the UK, and the US from 1980 to 2001. Furthermore, it shows that global and country effects are dominating factors driving liquidity. An asset pricing analysis suggests that expected stock returns are cross-sectionally related to the sensitivity of returns to shocks in global liquidity and that global liquidity is a priced state variable in an international asset pricing framework.
History of Adverse Pregnancy Outcomes, Blood Pressure, and Subclinical Vascular Measures in Late Midlife: SWAN (Study of Women's Health Across the Nation)

Background Adverse pregnancy outcomes, such as preterm birth (PTB), have been associated with elevated risk of maternal cardiovascular disease, but their effect on late midlife blood pressure (BP) and subclinical vascular measures remains understudied. Methods and Results We conducted a cross‐sectional analysis with 1220 multiethnic parous women enrolled in SWAN (Study of Women's Health Across the Nation) to evaluate the impact of self‐reported history of adverse pregnancy outcomes (PTB, small‐for‐gestational‐age, stillbirth), on maternal BP, mean arterial pressure, and subclinical vascular measures (carotid intima‐media thickness, plaque, and pulse wave velocity) in late midlife. We also examined whether these associations were modified by race/ethnicity. Associations were tested in linear and logistic regression models adjusting for sociodemographics, reproductive factors, cardiovascular risk factors, and medications. Women were on average aged 60 years and 255 women reported a history of an adverse pregnancy outcome. In fully adjusted models, history of PTB was associated with higher BP (systolic: β=6.40; SE, 1.62 [P<0.0001] and diastolic: β=3.18; SE, 0.98 [P=0.001]) and mean arterial pressure (β=4.55; SE 1.13 [P<0.0001]). PTB was associated with lower intima‐media thickness, but not after excluding women with prevalent hypertension. There were no significant associations with other subclinical vascular measures. Conclusions Findings suggest that history of PTB is associated with higher BP and mean arterial pressure in late midlife. Adverse pregnancy outcomes were not significantly related to subclinical cardiovascular disease when excluding women with prevalent hypertension. Future studies across the menopause transition may be important to assess the impact of adverse pregnancy outcomes on midlife progression of BP.
A Meta-Analysis of Predation Risk Effects on Pollinator Behaviour

Flower-visiting animals are constantly under predation risk when foraging and hence might be expected to evolve behavioural adaptations to avoid predators. We reviewed the available published and unpublished data to assess the overall effects of predators on pollinator behaviour and to examine sources of variation in these effects. The results of our meta-analysis showed that predation risk significantly decreased flower visitation rates (by 36%) and time spent on flowers (by 51%) by pollinators. The strength of the predator effects depended neither on predator taxa and foraging mode (sit-and-wait or active hunters) nor on pollinator lifestyle (social vs. solitary). However, predator effects differed among pollinator taxa: predator presence reduced flower visitation rates and time spent on flowers by Squamata, Lepidoptera and Hymenoptera, but not by Diptera. Furthermore, larger pollinators showed weaker responses to predation risk, probably because they are more difficult to capture. Presence of live crab spiders on flowers had weaker effects on pollinator behaviour than presence of dead or artificial crab spiders or other objects (e.g. dead bees, spheres), suggesting that predator crypsis may be effective to some extent. These results add to a growing consensus on the importance of considering both predator and pollinator characteristics from a community perspective.
Do emotional stimuli enhance or impede recall relative to neutral stimuli? An investigation of two “false memory” tasks

ABSTRACT Many eyewitness memory situations involve negative and distressing events; however, many studies investigating “false memory” phenomena use neutral stimuli only. The aim of the present study was to determine how both the Deese–Roediger–McDermott (DRM) procedure and the Misinformation Effect Paradigm tasks were related to each other using distressing and neutral stimuli. Participants completed the DRM (with negative and neutral word lists) and viewed a distressing or neutral film. Misinformation for the film was introduced and memory was assessed. Film accuracy and misinformation susceptibility were found to be greater for those who viewed the distressing film relative to the neutral film. Accuracy responses on both tasks were related, however, susceptibility to the DRM illusion and Misinformation Effect were not. The misinformation findings support the Paradoxical Negative Emotion (PNE) hypothesis that negative stimuli will lead to remembering more accurate details but also greater likelihood of memory distortion. However, the PNE hypothesis was not supported for the DRM results. The findings also suggest that the DRM and Misinformation tasks are not equivalent and may have differences in underlying mechanisms. Future research should focus on more ecologically valid methods of assessing false memory.