Miracle-dz/UniFAR-FTUs huggingface dataset:
Decreased antioxidant defense mechanisms in rat liver after methanol intoxication.

The primary metabolic fate of methanol is oxidation to formaldehyde and then to formate by enzymes of the liver. Cytochrome P-450 and a role for the hydroxyl radical have been implicated in this process. The aim of the paper was to study the liver antioxidant defense system in methanol intoxication, in doses of 1.5, 3.0 and 6.0 g/kg b.w. , after methanol administration to rats. In liver homogenates, the activities of Cu,Zn-superoxide dismutase and catalase were significantly increased after 6 h following methanol ingestion in doses of 3.0 and 6.0 g/kg b.w. and persisted up to 2-5 days, accompanied by significant decrease of glutathione reductase and glutathione peroxidase activities. The content of GSH was significantly decreased during 6 hours to 5 days. The liver ascorbate level was significantly diminished, too, while MDA levels were considerably increased after 1.5, 3.0 and 6.0 g/kg b.w. methanol intoxication. Changes due to methanol ingestion may indicate impaired antioxidant defense mechanisms in the liver tissue.
Sweetening the Carrot: Motivating Public Physicians for Better Performance

It is widely observed that many physicians working in public health facilities do not put in the required effort and time in their jobs. At the same time, many public physicians remain highly motivated, working long hours for little financial reward, in providing quality health services. This mix of provider-types poses fundamental challenges in the design of compensation mechanisms and monitoring regime in public facilities, where the objective of any reward-control paradigm is to improve the inoptimal performance of some physicians without compromising the effort of those already motivated. This paper presents a model to explain shirking behavior among public physicians and explores combinations of monitoring and incentive mechanisms that meet the twin objectives of inspiring the shirkers without losing the motivated. Drawing on the basic Shapiro-Stiglitz shirking model and the theory of social custom, the paper develops and presents a design of incentive structures that consists of punitive monitoring systems accompanied by non-pecuniary rewards. The analysis shows that intensive monitoring persuades the shirking physicians to improve their performance but may have a negative effect on the morale of those already motivated. The findings indicate that non-pecuniary rewards and recognition for the latter can potentially restore the incentives and counter the deleterious effect of increased supervision. The policy implications are discussed by presenting case studies in the health care context of developing countries.
Psychometric properties of the Dyadic Adjustment Scale (DAS) in a community sample of couples.

BACKGROUND This study analyzed the psychometric properties of the Dyadic Adjustment Scale (DAS). METHOD A sample of 1,180 participants, 590 adult heterosexual couples, from the Community of Madrid was examined via confirmatory factor analysis. RESULTS The results indicate that the factor structure of this scale fits the hierarchical factor model proposed by the test authors. The internal consistency, estimated using Cronbach's alpha coefficient was satisfactory for the total scale (alpha = .80) and ranged from . 13 to . 88 for the subscales. Convergent validity was adequate in comparison to the Negotiation subscale (emotional and cognitive) from the Revised Conflict Tactics Scales (CTS2). No significant differences were observed between genders. Finally, concordance or agreement between partners was high. The lowest agreement was found for the Affectional Expression subscale. CONCLUSIONS After examining the psychometric properties, the DAS was found to be a reliable and valid measurement of the sampled community of couples.
Multi-perspective target classification

Traditional radar classification is based on a single aspect view of the target. It is remarkably sensitive to the particular direction under which the target is sensed. A network of radars offers means of collecting backscattered radiation of a range of viewing angles. This offers multi-perspective data sets as an aid to improve radar target classification. By definition, this will provide a data set with higher information content. In this paper we examine whether this approach is useful for classification purposes. Results using full scale turntable demonstrate significant improvements in performance over and above the monostatic case.
Development of RAP binder characterisation tests for use within viscosity grade binder specification framework

Reclaimed asphalt pavement (RAP) is increasingly being re-used in new asphalt products. The properties of the binder in RAP will affect the behaviour of the asphalt material, especially for products containing a considerable proportion of RAP. This paper presents the results of a study aimed at developing an improved methodology of characterising RAP binder blends within a viscosity grade binder specification framework. The methodology comprises measurement of a complex viscosity parameter for the RAP binder using the dynamic shear rheometer (DSR). The parameter was selected to be comparable to the capillary tube viscosity, a test typically used in viscosity grade specifications for bitumen in Australia. The parameter can be used in the design of blends of RAP binder and virgin binder and/or rejuvenator to a specified viscosity value. The study included two experimental phases: the first phase was aimed at developing the DSR-based methodology for characterisation of the RAP binder; and in the second phase, performance-related tests on laboratory prepared asphalt mixes containing different percentages of RAP were performed to validate the binder characterisation methodology. The experimental work showed that the DSR can be used for viscosity measurement as an alternative to both the sliding plate micro-viscometer and the capillary viscosity test. The experiments on asphalt mixes containing various percentages of RAP showed the influence of RAP content on flexural modulus, fatigue and rut resistance of the material. The performance-related testing of asphalt mixes further confirmed that the RAP binder characterisation methodology developed as part of this study can be used to design binder blends containing RAP, virgin binder and rejuvenator, in such a way that the overall performance of a high RAP content mix is similar to that of a mix containing only virgin materials.
Visual Impressions of Pushing and Pulling: The Object Perceived as Causal is Not Always the One That Moves First

Stimuli were presented in which a moving object (A) contacted a stationary object (B), whereupon both objects moved back in the direction from which object A had come. When object B rapidly decelerated to a standstill, so that the two objects did not remain in contact, object B was perceived as pushing object A. Thus, even though object B only moved when contacted by object A, it was perceived as the causal object, as making something happen to object A. This is contrary to the hypothesis that the object perceived as causal is always the object that moves first. It is, however, consistent with a theoretical account, in which visual causal impressions occur through a process in which visually picked-up kinematic information is matched to stored representations, based on experiences of actions on objects, which specify forces and causality as part of the perceptual interpretation of the event.
Persistence in high-dimensional linear predictor selection and the virtue of overparametrization

Let Z = (Y , X 1, ., X i m), i = 1, . , n, be i.i. d. random vectors, Z ∼ F, F ∈ F . It is desired to predict Y by βjXj , where (β1, ., βm) ∈ B ⊆ R, under a prediction loss. Suppose that m = n, α > 1, i.e., there are many more explanatory variables than observations. We consider sets B restricted by the maximal number of non-zero coefficients of their members, or by their l1 radius. We study the following asymptotic question: How ‘large’ may the set B be, so that it is still possible to select empirically a predictor whose risk under F is close to that of the best predictor in the set. Sharp bounds for orders of magnitudes are given under various assumptions on F . Algorithmic complexity of the ensuing procedures is also studied. The main message of this paper and the implications of the above derived orders are that under various sparsity assumptions on the optimal predictor there is “asymptotically no harm” in introducing many more explanatory variables than observations. Furthermore, such practice can be beneficial in comparison with a procedure that screens in advance a small subset of explanatory variables. Another main result is that ’Lasso’-type procedures, i.e., optimization under l1 constraint, could be efficient in finding optimal sparse predictors in high dimensions. Running head: Persistence and Predictor Selection.
Progress in Joint-Action Research

Humans have a striking ability to coordinate their actions with each other to achieve joint goals. The tight interpersonal coordination that characterizes joint actions is achieved through processes that help with preparing for joint action as well as processes that are active while joint actions are being performed. To prepare for joint action, partners form representations of each other’s actions and tasks and the relation between them. This enables them to predict each other’s upcoming actions, which, in turn, facilitates coordination. While performing joint actions, partners’ coordination is maintained by (a) monitoring whether individual and joint outcomes correspond to what was planned, (b) predicting partners’ action parameters on the basis of familiarity with their individual actions, (c) communicating task-relevant information unknown to partners in an action-based fashion, and (d) relying on coupling of predictions through dense perceptual-information flow between coactors. The next challenge for the field of joint action is to generate an integrated perspective that links coordination mechanisms to normative, evolutionary, and communicative frameworks.
Inhibition of breast cancer growth in vivo by antiangiogenesis gene therapy with adenovirus-mediated antisense-VEGF

Increased expression of VEGF in several types of tumours has been shown to correlate with poor prognosis. We used a replication-deficient adenoviral vector containing antisense VEGF cDNA (Ad5CMV-αVEGF) to down-regulate VEGF expression and increase the efficiency of delivery of the antisense sequence in the human breast cancer cell line MDA231-MB. Transfection of these cells with Ad5CMV-αVEGF in vitro reduced secreted levels of VEGF protein without affecting cell growth. Moreover, injection of the Ad5CMV-αVEGF vector into intramammary xenografts of these cells established in nude mice inhibited tumour growth and reduced the amount of VEGF protein and the density of microvessels in those tumours relative to tumours treated with the control vector Ad5(dl312). Our results showed that antisense VEGF165cDNA was efficiently delivered in vivo via an adenoviral vector and that this treatment significantly inhibited the growth of established experimental breast tumours. The Ad5CMV-αVEGF vector may be useful in targeting the tumour vasculature in the treatment of breast cancer. © 2001 Cancer Research Campaign http://www.bjcancer. com
Postacute Reevaluation May Prevent Dysphagia-Associated Morbidity

Background and Purpose— Accurate identification and tailored management of patients with dysphagia is necessary to prevent complications when dysphagia is present and avoid implications of dietary restriction when unnecessary. Methods of dysphagia assessment vary, and a reassessment in the postacute period is not an established standard. The aim of this retrospective study was to compare initial dysphagia assessment with dysphagia reassessment results for stroke patients admitted to our inpatient rehabilitation facility. Methods— We examined medical records of 226 acute stroke patients admitted to our inpatient rehabilitation facility from December 2006 to May 2007. We excluded 86 subjects, then noted the presence or absence of dysphagia based on documentation and prescribed diet and management strategies in the remaining 146 records. Results— Dysphagia was identified in 94 patients (64%) assessed at our facility. Of these patients, 11% (n=10) were not previously identified in acute care (nonnegligible number, P<0.0001). Agreement regarding presence or absence of dysphagia occurred in 85%. However, prescribed diet differed in 51% (n=75), with 12% (n=18) requiring diet downgrades on admission for rehabilitation. Conclusions— The necessity of dysphagia reassessment as part of routine postacute stroke rehabilitation care is not completely established. Our study supports the need for postacute reassessment as 11% of patients with dysphagia would not have been identified without reassessment and 12% required diets more conservative than prescribed in acute care. Prospective research addressing dysphagia specific outcomes is warranted to develop efficient and high-quality standards for preventing poststroke dysphagia associated morbidity.
Shiga Toxin 1-Induced Proinflammatory Cytokine Production Is Regulated by the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Signaling Pathway

ABSTRACT Shiga toxin 1 (Stx1) transiently increases the expression of proinflammatory cytokines by macrophage-like THP-1 cells in vitro. Increased cytokine production is partly due to activation of the translation initiation factor eIF4E through a mitogen-activated protein kinase (MAPK)- and Mnk1-dependent pathway. eIF4E availability for translation initiation is regulated by association with eIF4E binding proteins (4E-BP). In this study, we showed that Stx1 transiently induced 4E-BP hyperphosphorylation, which may release eIF4E for translation initiation. Phosphorylation of 4E-BP at priming sites T37 and T46 was not altered by Stx1 but was transiently increased at S65, concomitant with increased cytokine expression. Using kinase inhibitors, we showed that 4E-BP phosphorylation was dependent on phosphatidylinositol 3-kinase (PI3K), Akt, and mammalian target of rapamycin (mTOR) activation but did not require MAPKs. Stx1 treatment resulted in increased levels of cytosolic Ca2+. PI3K and Akt activation led to the phosphorylation and inactivation of the positive cytokine regulator glycogen synthase kinase 3α/β (GSK-3α/β). PI3K, Akt, and mTOR inhibitors and small interfering RNA knockdown of Akt expression all increased, whereas a GSK-3α/β inhibitor decreased, Stx1-induced soluble tumor necrosis factor alpha and interleukin-1β production. Overall, these findings suggest that despite transient activation of 4E-BP, the PI3K/Akt/mTOR pathway negatively influences cytokine induction by inactivating the positive regulator GSK-3α/β.
Professional Carers' Experiences of Providing a Pediatric Palliative Care Service in Ireland

In this article the authors present findings on professional carers' experience of providing pediatric palliative care to children with life-limiting conditions. For this qualitative study, part of a national pediatric palliative care needs analysis, the authors engaged in 15 focus group interviews and drew on the responses of open-ended questions to give voice to the experiences of professional carers and to situate the humanity of their caring reality. This humanity is articulated through three themes: clarity of definition and complexity of engagement, seeking to deliver a palliative care service, and the emotional cost of providing palliative care. Further analysis of these themes points to a work-life experience of skilled and emotional engagement with children, and their parents, in complex processes of caregiving and decision making. Pediatric palliative care occurs in an environment where parents shoulder a large burden of the care and professionals find themselves working in underresourced services.
Variational Laws of Visual Attention for Dynamic Scenes

Computational models of visual attention are at the crossroad of disciplines like cognitive science, computational neuroscience, and computer vision. This paper proposes a model of attentional scanpath that is based on the principle that there are foundational laws that drive the emergence of visual attention. We devise variational laws of the eye-movement that rely on a generalized view of the Least Action Principle in physics. The potential energy captures details as well as peripheral visual features, while the kinetic energy corresponds with the classic interpretation in analytic mechanics. In addition, the Lagrangian contains a brightness invariance term, which characterizes significantly the scanpath trajectories. We obtain differential equations of visual attention as the stationary point of the generalized action, and we propose an algorithm to estimate the model parameters. Finally, we report experimental results to validate the model in tasks of saliency detection.
Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling

The disruption of normal hematopoiesis has been observed in leukemia, but the mechanism is unclear. Osteoblasts originate from bone mesenchymal stem cells (BMSCs) and can maintain normal hematopoiesis. To investigate how leukemic cells inhibit the osteogenic differentiation of BMSCs and the role of Notch signaling in this process, we cocultured BMSCs with acute lymphoblastic leukemia (ALL) cells in osteogenic induction medium. The expression levels of Notch1, Hes1, and the osteogenic markers Runx2, Osteopontin (OPN), and Osteocalcin (OCN) were assessed by real-time RT-PCR and western blotting on day 3. Alkaline phosphatase (ALP) activity was analyzed using an ALP kit, and mineralization deposits were detected by Alizarin red S staining on day 14. And then we treated BMSCs with Jagged1 and anti-Jagged1 neutralizing Ab. The expression of Notch1, Hes1, and the abovementioned osteogenic differentiation markers was measured. Inhibition of the expression of Runx2, OPN, and OCN and reduction of ALP activity and mineralization deposits were observed in BMSCs cocultured with ALL cells, while Notch signal inhibiting rescued these effects. All these results indicated that ALL cells could inhibit the osteogenic differentiation of BMSCs by activating Notch signaling, resulting in a decreased number of osteoblastic cells, which may impair normal hematopoiesis.
N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons

ABSTRACT Axonogenesis, a process for the establishment of neuron connectivity, is central to brain function. The role of metabolites derived from docosahexaenoic acid (DHA, 22:6n-3) that is specifically enriched in the brain, has not been addressed in axon development. In this study, we tested if synaptamide (N-docosahexaenoylethanolamine), an endogenous metabolite of DHA, affects axon growth in cultured cortical neurons. We found that synaptamide increased the average axon length, inhibited GLI family zinc finger 1 (GLI1) transcription and sonic hedgehog (Shh) target gene expression while inducing cAMP elevation. Similar effects were produced by cyclopamine, a regulator of the Shh pathway. Conversely, Shh antagonized elevation of cAMP and blocked synaptamide-mediated increase in axon length. Activation of Shh pathway by a smoothened (SMO) agonist (SAG) or overexpression of SMO did not inhibit axon growth mediated by synaptamide or cyclopamine. Instead, adenylate cyclase inhibitor SQ22536 abolished synaptamide-mediated axon growth indicating requirement of cAMP elevation for this process. Our findings establish that synaptamide promotes axon growth while Shh antagonizes synaptamide-mediated cAMP elevation and axon growth by a SMO-independent, non-canonical pathway. Summary: Synaptamide, an omega-3 fatty acid metabolite, promotes axon growth while Shh antagonizes synaptamide-mediated axon growth by a SMO-independent, non-canonical pathway.
Empirical Analysis on Comparing the Performance of Alpha Miner Algorithm in SQL Query Language and NoSQL Column-Oriented Databases Using Apache Phoenix

Process-Aware Information Systems (PAIS) is an IT system that support business processes and generate large amounts of event logs from the execution of business processes. An event log is represented as a tuple of CaseID, Timestamp, Activity and Actor. Process Mining is a new and emerging field that aims at analyzing the event logs to discover, enhance and improve business processes and check conformance between run time and design time business processes. The large volume of event logs generated are stored in the databases. Relational databases perform well for a certain class of applications. However, there are a certain class of applications for which relational databases are not able to scale. To handle such class of applications, NoSQL database systems emerged. Discovering a process model (workflow model) from event logs is one of the most challenging and important Process Mining task. The $\alpha$-miner algorithm is one of the first and most widely used Process Discovery technique. Our objective is to investigate which of the databases (Relational or NoSQL) performs better for a Process Discovery application under Process Mining. We implement the $\alpha$-miner algorithm on relational (row-oriented) and NoSQL (column-oriented) databases in database query languages so that our algorithm is tightly coupled to the database. We present a performance benchmarking and comparison of the $\alpha$-miner algorithm on row-oriented database and NoSQL column-oriented database so that we can compare which database can efficiently store massive event logs and analyze it in seconds to discover a process model.
Larger Extrastriate Population Receptive Fields in Autism Spectrum Disorders

Previous behavioral research suggests enhanced local visual processing in individuals with autism spectrum disorders (ASDs). Here we used functional MRI and population receptive field (pRF) analysis to test whether the response selectivity of human visual cortex is atypical in individuals with high-functioning ASDs compared with neurotypical, demographically matched controls. For each voxel, we fitted a pRF model to fMRI signals measured while participants viewed flickering bar stimuli traversing the visual field. In most extrastriate regions, perifoveal pRFs were larger in the ASD group than in controls. We observed no differences in V1 or V3A. Differences in the hemodynamic response function, eye movements, or increased measurement noise could not account for these results; individuals with ASDs showed stronger, more reliable responses to visual stimulation. Interestingly, pRF sizes also correlated with individual differences in autistic traits but there were no correlations with behavioral measures of visual processing. Our findings thus suggest that visual cortex in ASDs is not characterized by sharper spatial selectivity. Instead, we speculate that visual cortical function in ASDs may be characterized by extrastriate cortical hyperexcitability or differential attentional deployment.