Miracle-dz/UniFAR-FTUs huggingface dataset:
Pediatric Skin Disorders Encountered in a Dermatology Outpatient Clinic in Turkey

Abstract: This study documents the spectrum and frequency of skin disorders in a total of 2370 children encountered in a dermatology outpatient clinic in Turkey. Infectious skin diseases were most frequently observed (27.6%) followed by, eczemas (17.9%), acne (14,5%), papulosquamous diseases (6.9%), hair diseases (4.1%), pigmentation disorders (3.8%), generalized pruritus (2.8%), urticaria (2.7%), and insect bite (2.3%). Epidemiologic data are useful in planning of the health care and taking preventive measures to decrease the prevalence of skin disorders in children.
Novel insight in the association between salmonellosis or campylobacteriosis and chronic illness, and the role of host genetics in susceptibility to these diseases

SUMMARY We studied the role of host genetics in the susceptibility to severe Salmonella and Campylobacter infections and chronic sequelae of these infections. Participants of a previous case-control study were sent a buccal swab kit and a questionnaire about occurrence of chronic sequelae. Single nucleotide polymorphisms (SNPs) in the TLR4 (rs4986790), IFNG (rs2430561 and rs1861493), STAT1 (rs1914408), IL1B (rs16944), NRAMP (SLC11A1 rs2276631), JUN (rs11688) and VDR (rs10735810) genes were determined. In total, 687 controls, 457 Campylobacter cases and 193 Salmonella cases participated. None of the SNPs were associated with Campylobacter or Salmonella infections. None of the participants developed Guillain–Barré, Miller–Fisher or Reiter's syndrome. Reactive arthritis occurred in 5% and 2% of cases and controls, respectively. Campylobacter cases more frequently experienced gastroenteritis episodes than controls. Campylobacter or Salmonella infection in women, use of proton pump inhibitors and an SNP in the IFNG gene were independent risk factors for reactive arthritis. Another SNP in the IFNG gene and use of proton pump inhibitors were risk factors for recurrent episodes of gastroenteritis. In conclusion, reactive arthritis and recurrent gastroenteritis episodes are common after infection and host genetic factors play a role in susceptibility to these long-term health effects.
Blending Speech Output and Visual Text in the Multimodal Interface

Objective: Simultaneous reading and listening with a redundant display of visual text with speech output was investigated to determine how variations in verbal working memory capacity and content complexity affected comprehension. Background: Previous work has found some evidence of a benefit for displays that blend speech and visual text; content complexity and verbal working memory capacity are likely to significantly determine this benefit. Method: In the experiment reported here, a multimodal display of e-mail messages was compared with speech output alone and with a purely visual display. Comprehension of the messages was examined in relation to verbal working memory capacity and the complexity of the messages. Thirty-two users participated in the study, which used a repeated measures design. Results: The data show that the multimodal interface did not affect comprehension relative to a purely visual interface, even when the content was more complex, although it did improve the comprehension of complex information relative to a purely auditory interface. Lower-capacity participants were neither especially advantaged nor disadvantaged by the multimodal interface. Participants expressed a marked preference for the multimodal display of the more complex sentences. Conclusion: The experiment suggests that a redundant multimodal display will neither assist nor disrupt understanding when compared with a purely visual display, but it will assist understanding of complex content when compared with speech output alone. Application: Redundant displays of visual text and speech have potential application in multitask situations, in multimedia presentations, and for devices with small screens.
White Matter Integrity Predicts Delay Discounting Behavior in 9- to 23-Year-Olds: A Diffusion Tensor Imaging Study

Healthy participants (n = 79), ages 9–23, completed a delay discounting task assessing the extent to which the value of a monetary reward declines as the delay to its receipt increases. Diffusion tensor imaging (DTI) was used to evaluate how individual differences in delay discounting relate to variation in fractional anisotropy (FA) and mean diffusivity (MD) within whole-brain white matter using voxel-based regressions. Given that rapid prefrontal lobe development is occurring during this age range and that functional imaging studies have implicated the prefrontal cortex in discounting behavior, we hypothesized that differences in FA and MD would be associated with alterations in the discounting rate. The analyses revealed a number of clusters where less impulsive performance on the delay discounting task was associated with higher FA and lower MD. The clusters were located primarily in bilateral frontal and temporal lobes and were localized within white matter tracts, including portions of the inferior and superior longitudinal fasciculi, anterior thalamic radiation, uncinate fasciculus, inferior fronto-occipital fasciculus, corticospinal tract, and splenium of the corpus callosum. FA increased and MD decreased with age in the majority of these regions. Some, but not all, of the discounting/DTI associations remained significant after controlling for age. Findings are discussed in terms of both developmental and age-independent effects of white matter organization on discounting behavior.
Teleconsultation for emergency orthopaedic patients using the multimedia messaging service via mobile phones

We investigated the accuracy and usefulness of teleconsultation using the mobile phone multimedia messaging service (MMS) in emergency orthopaedic patients. Pictures of radiographs were taken using a built-in 1.3 megapixel mobile phone camera from a digital display screen in the emergency room and then transmitted to the camera phones of four assessors. The cases comprised 59 emergency orthopaedic patients diagnosed with non- or minimally displaced fractures and 34 age-matched normal patients visiting the emergency department. Both clinical and radiographic follow up data were used as the gold standard. Inter- and intra-observer agreement were good (kappa>0.60). The overall sensitivity, specificity and accuracy were 78%, 54% and 65%, respectively. The overall misdiagnosis rate was 40%, with over-diagnosis of 12% and under-diagnosis of 27%. The consequence of misdiagnosis would have resulted in mismanagement in up to 48% of the cases. No association was found between the experience of the assessors, the region of the fracture or the age group of the patients and the misdiagnosis rate. Teleconsultation via MMS demonstrated good reliability, but poor diagnostic accuracy which could have major consequences in emergency orthopaedic patients.
The CCR5 and CXCR4 Coreceptors Are Both Used by Human Immunodeficiency Virus Type 1 Primary Isolates from Subtype C

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) subtype C viruses with different coreceptor usage profiles were isolated from 29 South African patients with advanced AIDS. All 24 R5 isolates were inhibited by the CCR5-specific agents, PRO 140 and RANTES, while the two X4 viruses and the three R5X4 viruses were sensitive to the CXCR4-specific inhibitor, AMD3100. The five X4 or R5X4 viruses were all able to replicate in peripheral blood mononuclear cells that did not express CCR5. When tested using coreceptor-transfected cell lines, one R5 virus was also able to use CXCR6, and another R5X4 virus could use CCR3, BOB/GPR15, and CXCR6. The R5X4 and X4 viruses contained more-diverse V3 loop sequences, with a higher overall positive charge, than the R5 viruses. Hence, some HIV-1 subtype C viruses are able to use CCR5, CXCR4, or both CXCR4 and CCR5 for entry, and they are sensitive to specific inhibitors of entry via these coreceptors. These observations are relevant to understanding the rapid spread of HIV-1 subtype C in the developing world and to the design of intervention and treatment strategies.
Finite-sum Composition Optimization via Variance Reduced Gradient Descent

The stochastic composition optimization proposed recently by Wang et al. [2014] minimizes the objective with the compositional expectation form: $\min_x~(\mathbb{E}_iF_i \circ \mathbb{E}_j G_j)(x). $ It summarizes many important applications in machine learning, statistics, and finance. In this paper, we consider the finite-sum scenario for composition optimization: \[\min_x f (x) := \frac{1}{n} \sum_{i = 1}^n F_i \left(\frac{1}{m} \sum_{j = 1}^m G_j (x) \right). \] We propose two algorithms to solve this problem by combining the stochastic compositional gradient descent (SCGD) and the stochastic variance reduced gradient (SVRG) technique. A constant linear convergence rate is proved for strongly convex optimization, which substantially improves the sublinear rate $O(K^{-0.8})$ of the best known algorithm.
The efficacy of psychodynamic psychotherapy.

Empirical evidence supports the efficacy of psychodynamic therapy. Effect sizes for psychodynamic therapy are as large as those reported for other therapies that have been actively promoted as "empirically supported" and "evidence based. " In addition, patients who receive psychodynamic therapy maintain therapeutic gains and appear to continue to improve after treatment ends. Finally, nonpsychodynamic therapies may be effective in part because the more skilled practitioners utilize techniques that have long been central to psychodynamic theory and practice. The perception that psychodynamic approaches lack empirical support does not accord with available scientific evidence and may reflect selective dissemination of research findings.
Mechanical model testing of rebreathing potential in infant bedding materials

Rebreathing of expired air may be a lethal hazard for prone sleeping infants. This paper describes a mechanical model to simulate infant breathing, and examines the effects of bedding on exhaled air retention. Under simulated rebreathing conditions, the model allows the monitoring of raised carbon dioxide (CO2) inside an artificial lung–trachea system. Resulting levels of CO2(although probably exaggerated in the mechanical model compared with an infant, due to the model’s fixed breathing rate and volume) suggest that common bedding materials vary widely in inherent rebreathing potential. In face down tests, maximum airway CO2 ranged from less than 5% on sheets and waterproof mattresses to over 25% on sheepskins, bean bag cushions, and some pillows and comforters. Concentrations of CO2 decreased with increasing head angle of the doll, away from the face down position. Recreations of 29 infant death scenes also showed large CO2 increases on some bedding materials, suggesting these infants could have died while rebreathing.
Mechanical Stress Promotes Maturation of Human Myocardium From Pluripotent Stem Cell‐Derived Progenitors

Recent advances in pluripotent stem cell biology and directed differentiation have identified a population of human cardiovascular progenitors that give rise to cardiomyocytes, smooth muscle, and endothelial cells. Because the heart develops from progenitors in 3D under constant mechanical load, we sought to test the effects of a 3D microenvironment and mechanical stress on differentiation and maturation of human cardiovascular progenitors into myocardial tissue. Progenitors were derived from embryonic stem cells, cast into collagen hydrogels, and left unstressed or subjected to static or cyclic mechanical stress. Compared to 2D culture, the unstressed 3D environment increased cardiomyocyte numbers and decreased smooth muscle numbers. Additionally, 3D culture suppressed smooth muscle α‐actin content, suggesting diminished cell maturation. Cyclic stress‐conditioning increased expression of several cardiac markers, including β‐myosin heavy chain and cardiac troponin T, and the tissue showed enhanced calcium dynamics and force production. There was no effect of mechanical loading on cardiomyocyte or smooth muscle specification. Thus, 3D growth conditions favor cardiac differentiation from cardiovascular progenitors, whereas 2D conditions promote smooth muscle differentiation. Mechanical loading promotes cardiomyocyte structural and functional maturation. Culture in 3‐D facilitates understanding how cues such as mechanical stress affect the differentiation and morphogenesis of distinct cardiovascular cell populations into organized, functional human cardiovascular tissue. Stem Cells 2015;33:2148–2157
Utilization of Alkali-Activated Olivine in Soil Stabilization and the Effect of Carbonation on Unconfined Compressive Strength and Microstructure

This paper reports for the first time the stabilization of soil using olivine and the application of novel techniques utilizing alkaline activation and carbonation. A rigorous study addressed the effect of carbon dioxide pressure and alkali concentration (10-M sodium hydroxide soil additions from 5 to 20%) between 7 and 90 days. Microstructural and compositional changes were evaluated using microscopic, spectroscopic, and diffraction techniques. Results demonstrate the advantages of using olivine in the presence of NaOH and the associated increases in soil shear strength of up to 40% over 90 days. Samples subjected to carbonation for a further 7 days led to additional increases in soil strength of up to 60%. Microstructural investigations before and after carbonation attributed the strength development to the formation of Mg(OH)2, hydrated magnesium carbonates, and M─S─H, A─S─H gel phases. The impact of this work is far reaching and provides a new soil stabilization approach. Key advantages include significant improvements in soil strength with a lower carbon footprint compared with lime or cement stabilization.
Molecular Characterization of Echinococcus granulosus through Amplification of 12S rRNA Gene and Cox1 Gene Fragments from Cattle in Chittagong, Bangladesh

Abstract—The dog tapeworms Echinococcus granulosus develop hydatid cysts in various organs in human and domestic animals worldwide including Bangladesh. The aim of this study was to identify and characterize the genotype of E. granulosus isolated from cattle using 12S rRNA and Cytochrome oxidase 1 (COX 1) genes. A total of 43 hydatid cyst samples were collected from 390 examined cattle samples derived from slaughterhouses. Among them, three cysts were fertile. Genomic DNA was extracted from germinal membrane and/or protoscoleces followed by PCR amplification of mitochondrial 12S rRNA and Cytochrome oxidase 1 gene fragments. The sequence data revealed existence of G1 (64.28%) and possible G3 (21.43%) genotypes for the first time in Bangladesh. The study indicates that common sheep strain G1 is the dominant subtype of E. granulosus in Chittagong region of Bangladesh. This will increase our understanding of the epidemiology of hydatidosis in the southern part of the country and will be useful to plan suitable control measures in the long run.
Computational Characterization of Visually Induced Auditory Spatial Adaptation

Recent research investigating the principles governing human perception has provided increasing evidence for probabilistic inference in human perception. For example, human auditory and visual localization judgments closely resemble that of a Bayesian causal inference observer, where the underlying causal structure of the stimuli are inferred based on both the available sensory evidence and prior knowledge. However, most previous studies have focused on characterization of perceptual inference within a static environment, and therefore, little is known about how this inference process changes when observers are exposed to a new environment. In this study we aimed to computationally characterize the change in auditory spatial perception induced by repeated auditory–visual spatial conflict, known as the ventriloquist aftereffect. In theory, this change could reflect a shift in the auditory sensory representations (i.e., shift in auditory likelihood distribution), a decrease in the precision of the auditory estimates (i.e., increase in spread of likelihood distribution), a shift in the auditory bias (i.e., shift in prior distribution), or an increase/decrease in strength of the auditory bias (i.e., the spread of prior distribution), or a combination of these. By quantitatively estimating the parameters of the perceptual process for each individual observer using a Bayesian causal inference model, we found that the shift in the perceived locations after exposure was associated with a shift in the mean of the auditory likelihood functions in the direction of the experienced visual offset. The results suggest that repeated exposure to a fixed auditory–visual discrepancy is attributed by the nervous system to sensory representation error and as a result, the sensory map of space is recalibrated to correct the error.
Pay-as-you-go user feedback for dataspace systems

A primary challenge to large-scale data integration is creating semantic equivalences between elements from different data sources that correspond to the same real-world entity or concept. Dataspaces propose a pay-as-you-go approach: automated mechanisms such as schema matching and reference reconciliation provide initial correspondences, termed candidate matches, and then user feedback is used to incrementally confirm these matches. The key to this approach is to determine in what order to solicit user feedback for confirming candidate matches. In this paper, we develop a decision-theoretic framework for ordering candidate matches for user confirmation using the concept of the value of perfect information (VPI). At the core of this concept is a utility function that quantifies the desirability of a given state; thus, we devise a utility function for dataspaces based on query result quality. We show in practice how to efficiently apply VPI in concert with this utility function to order user confirmations. A detailed experimental evaluation on both real and synthetic datasets shows that the ordering of user feedback produced by this VPI-based approach yields a dataspace with a significantly higher utility than a wide range of other ordering strategies. Finally, we outline the design of Roomba, a system that utilizes this decision-theoretic framework to guide a dataspace in soliciting user feedback in a pay-as-you-go manner.
Contribution of Prior Semantic Knowledge to New Episodic Learning in Amnesia

We evaluated whether prior semantic knowledge would enhance episodic learning in amnesia. Subjects studied prices that are either congruent or incongruent with prior price knowledge for grocery and household items and then performed a forced-choice recognition test for the studied prices. Consistent with a previous report, healthy controls' performance was enhanced by price knowledge congruency; however, only a subset of amnesic patients experienced the same benefit. Whereas patients with relatively intact semantic systems, as measured by an anatomical measure (i.e., lesion involvement of anterior and lateral temporal lobes), experienced a significant congruency benefit, patients with compromised semantic systems did not experience a congruency benefit. Our findings suggest that when prior knowledge structures are intact, they can support acquisition of new episodic information by providing frameworks into which such information can be incorporated.
Increased conspicuousness can explain the match between visual sensitivities and blue plumage colours in fairy-wrens

Colour signals are expected to match visual sensitivities of intended receivers. In birds, evolutionary shifts from violet-sensitive (V-type) to ultraviolet-sensitive (U-type) vision have been linked to increased prevalence of colours rich in shortwave reflectance (ultraviolet/blue), presumably due to better perception of such colours by U-type vision. Here we provide the first test of this widespread idea using fairy-wrens and allies (Family Maluridae) as a model, a family where shifts in visual sensitivities from V- to U-type eyes are associated with male nuptial plumage rich in ultraviolet/blue colours. Using psychophysical visual models, we compared the performance of both types of visual systems at two tasks: (i) detecting contrast between male plumage colours and natural backgrounds, and (ii) perceiving intraspecific chromatic variation in male plumage. While U-type outperforms V-type vision at both tasks, the crucial test here is whether U-type vision performs better at detecting and discriminating ultraviolet/blue colours when compared with other colours. This was true for detecting contrast between plumage colours and natural backgrounds (i), but not for discriminating intraspecific variability (ii). Our data indicate that selection to maximize conspicuousness to conspecifics may have led to the correlation between ultraviolet/blue colours and U-type vision in this clade of birds.
Key Competencies of Tourism Graduates: The Employers' Point of View

Several changes and developments (e.g., the changing labor market, growing worldwide competition, technological advances, and changing demand patterns in tourism) require new employability skills from graduates that enable them to cope with the changing circumstances of the tourism business world. Universities are therefore encouraged to embed key skills in their curricula, yet there is often a considerable gap between what educational institutions offer and what is needed and required by the industry (i.e., there is a need to create a hub and interface between the industry and the institutions of higher education). One attempt to actually create this interface and increase the opportunities for graduates to maintain or obtain employment is to look at diverse skills and competencies that enhance employability of graduates. Although there have been considerable efforts to specify employability skills, the question of how these could be developed within the curriculum prevails. The purpose of the present paper is to theoretically discuss the concepts of employability, skills requirements, and competencies for graduates and to present the results of a quantitative survey carried out among domestic and international Management Center Innsbruck internship partners to assess the required employability skills of the market from the employers' point of view.
Practitioner Review: Borderline personality disorder in adolescence--recent conceptualization, intervention, and implications for clinical practice.

BACKGROUND The past decade has seen an unprecedented increase in research activity on personality disorders (PDs) in adolescents. The increase in research activity, in addition to major nosological systems legitimizing the diagnosis of borderline personality disorder (BPD) in adolescents, highlights the need to communicate new research on adolescent personality problems to practitioners. SCOPE In this review, we provide up-to-date information on the phenomenology, prevalence, associated clinical problems, etiology, and intervention for BPD in adolescents. Our aim was to provide a clinically useful practitioner review and to dispel long-held myths about the validity, diagnostic utility, and treatability of PDs in adolescents. FINDINGS AND CONCLUSION Alongside providing up-to-date information on the phenomenology, prevalence, and etiology, we also report on associated clinical problems and interventions for adolescent BPD. It is only through early active assessment and identification of youngsters with these problems that a lifetime of personal suffering and health system burden can be reduced or altogether avoided. A variety of evidence-based approaches are now available to treat BPD and related clinical problems in young people. Future research should focus on establishing optimal precision in the diagnostic processes in different treatment settings.