Miracle-dz/UniFAR-FTUs huggingface dataset:
Healthy Aging Delays Scalp EEG Sensitivity to Noise in a Face Discrimination Task

We used a single-trial ERP approach to quantify age-related changes in the time-course of noise sensitivity. A total of 62 healthy adults, aged between 19 and 98, performed a non-speeded discrimination task between two faces. Stimulus information was controlled by parametrically manipulating the phase spectrum of these faces. Behavioral 75% correct thresholds increased with age. This result may be explained by lower signal-to-noise ratios in older brains. ERP from each subject were entered into a single-trial general linear regression model to identify variations in neural activity statistically associated with changes in image structure. The fit of the model, indexed by R2, was computed at multiple post-stimulus time points. The time-course of the R2 function showed significantly delayed noise sensitivity in older observers. This age effect is reliable, as demonstrated by test–retest in 24 subjects, and started about 120 ms after stimulus onset. Our analyses suggest also a qualitative change from a young to an older pattern of brain activity at around 47 ± 4 years old.
Implications of Vygotsky ' s Theory for Peer Learning

~ The termspeerlearningandcooperative learninghavebeen usedto describequite different forms of interactions, with different goals, peer arrangements, and types of activities. In this chapter, we focus specificallyon peer learning that is related to collaborative problem solving, typically involving two children. The roots of research on this type of peer learning are not in the field of education, but in developmental psychology, with much of the research occurring in university laboratories or in school, rather than involving the study of group processes in the classroom. In what ways is Vygotsky's theory relevant to a discussion of collaborative peer learning? Vygotsky's theory views human development as a sociogenetic process by which children gain mastery over cultural tools and signs in the course of interacting with others in their environments. These others are often more competent and help children to understand and use in appropriate ways the tools and signs that are important in the cultural group into which they have been born. This process of interaction between the child and a more competent other is said to effect development if the interaction occurs within the child's zone of proximal development. Although this summary is true to Vygotsky's position, we must not conflate Vygotsky's theory with one small part of the theory; we need to go further if we are to make progress in our understanding of collaboration from a Vygotskian perspective. When scholars study collaboration using a Vygotskian framework, the most commonly cited concept is that of the zone of proximal development,
Review of Evidence for Adult Diabetic Ketoacidosis Management Protocols

Background Diabetic ketoacidosis (DKA) is an endocrine emergency with associated risk of morbidity and mortality. Despite this, DKA management lacks strong evidence due to the absence of large randomised controlled trials (RCTs). Objective To review existing studies investigating inpatient DKA management in adults, focusing on intravenous (IV) fluids; insulin administration; potassium, bicarbonate, and phosphate replacement; and DKA management protocols and impact of DKA resolution rates on outcomes. Methods Ovid Medline searches were conducted with limits “all adult” and published between “1973 to current” applied. National consensus statements were also reviewed. Eligibility was determined by two reviewers’ assessment of title, abstract, and availability. Results A total of 85 eligible articles published between 1973 and 2016 were reviewed. The salient findings were (i) Crystalloids are favoured over colloids though evidence is lacking. The preferred crystalloid and hydration rates remain contentious. (ii) IV infusion of regular human insulin is preferred over the subcutaneous route or rapid acting insulin analogues. Administering an initial IV insulin bolus before low-dose insulin infusions obviates the need for supplemental insulin. Consensus-statements recommend fixed weight-based over “sliding scale” insulin infusions although evidence is weak. (iii) Potassium replacement is imperative although no trials compare replacement rates. (iv) Bicarbonate replacement offers no benefit in DKA with pH > 6.9. In severe metabolic acidosis with pH < 6.9, there is lack of both data and consensus regarding bicarbonate administration. (v) There is no evidence that phosphate replacement offers outcome benefits. Guidelines consider replacement appropriate in patients with cardiac dysfunction, anaemia, respiratory depression, or phosphate levels <0.32 mmol/L. (vi) Upon resolution of DKA, subcutaneous insulin is recommended with IV insulin infusions ceased with an overlap of 1–2 h. (vii) DKA resolution rates are often used as end points in studies, despite a lack of evidence that rapid resolution improves outcome. (viii) Implementation of DKA protocols lacks strong evidence for adherence but may lead to improved clinical outcomes. Conclusion There are major deficiencies in evidence for optimal management of DKA. Current practice is guided by weak evidence and consensus opinion. All aspects of DKA management require RCTs to affirm or redirect management and formulate consensus evidence-based practice to improve patient outcomes.
Effect of nurse practitioner and pharmacist counseling on inappropriate medication use in family practice.

OBJECTIVE To measure the effect of nurse practitioner and pharmacist consultations on the appropriate use of medications by patients. DESIGN We studied patients in the intervention arm of a randomized controlled trial. The main trial intervention was provision of multidisciplinary team care and the main outcome was quality and processes of care for chronic disease management. SETTING Patients were recruited from a single publicly funded family health network practice of 8 family physicians and associated staff serving 10 000 patients in a rural area near Ottawa, Ont. PARTICIPANTS A total of 120 patients 50 years of age or older who were on the practice roster and who were considered by their family physicians to be at risk of experiencing adverse health outcomes. INTERVENTION A pharmacist and 1 of 3 nurse practitioners visited each patient at his or her home, conducted a comprehensive medication review, and developed a tailored plan to optimize medication use. The plan was developed in consultation with the patient and the patient's doctor. We assessed medication appropriateness at the study baseline and again 12 to 18 months later. MAIN OUTCOME MEASURES We used the medication appropriateness index to assess medication use. We examined associations between personal characteristics and inappropriate use at baseline and with improvements in medication use at the follow-up assessment. We recorded all drug problems encountered during the trial. RESULTS At baseline, 27.2% of medications were inappropriate in some way and 77.7% of patients were receiving at least 1 medication that was inappropriate in some way. At the follow-up assessments these percentages had dropped to 8.9% and 38.6%, respectively (P < .001). Patient characteristics that were associated with receiving inappropriate medication at baseline were being older than 80 years of age (odds ratio [OR] = 5.00, 95% CI 1.19 to 20.50), receiving more than 4 medications (OR = 6.64, 95% CI 2.54 to 17.4), and not having a university-level education (OR = 4.55, 95% CI 1.69 to 12.50). CONCLUSION We observed large improvements in the appropriate use of medications during this trial. This might provide a mechanism to explain some of the reductions in mortality and morbidity observed in other trials of counseling and advice provided by pharmacists and nurses. TRIAL REGISTRATION NUMBER NCT00238836 (ClinicalTrials.gov).
, Exercise and Early Recovery in Patients With Congestive Heart Failure Respiratory Muscles Performance Is Related to Oxygen Kinetics During Maximal

Background—Dyspnea and fatigue are the main causes of exercise limitation in chronic heart failure (CHF) patients, whose peak inspiratory (Pimax) and expiratory pressures (Pemax) are often reduced. The aim of this study was to examine the relationship between respiratory muscle performance and oxygen kinetics. Methods and Results—A total of 55 patients (NYHA class I to III) and 11 healthy subjects underwent cardiopulmonary exercise tests (CPET) on a treadmill. In 45 of the 55 patients (group I) and in healthy subjects (group II), pulmonary function tests, Pimax, and Pemax were measured before and 10 minutes after exercise, and oxygen kinetics were monitored throughout and during early recovery from CPET. The first degree slope of oxygen consumption (V̇O2) decline during early recovery (V̇O2/t-slope) and V̇O2 half-time (T1/2) were calculated. In 10 of the 55 CHF patients (group III), the measurements of Pimax were repeated 2, 5, and 10 minutes after CPET. A . 10% reduction in Pimax after CPET (subgroup IA) was measured in 11 of 45 patients. In contrast, 34 of 45 CHF patients (subgroup IB) and all control subjects (group II) had Pimax.90% of baseline value after CPET. Subgroup IA patients had significantly lower peak V̇O2 (13.562.1 versus 17.865.6 mL z kg z min; P,0.001), lower anaerobic thresholds (10.162.4 versus 13.664.6 mL z kg z min; P50.003) and lower V̇O2/t-slopes (0.36560.126 versus 0.51960.227 L z min 21 z min; P50.008) than subgroup IB patients. Conclusions—The reduction of Pimax after exercise is associated with prolonged early recovery of oxygen kinetics, which may explain, in part, the role played by respiratory muscles in exercise intolerance in CHF patients. (Circulation. 1999;100:503-508.)
Scrapie in the central nervous system: neuroanatomical spread of infection and Sinc control of pathogenesis.

Following bilateral intraocular (i.o.) infection of Sinc s7 mice with ME7 scrapie, sequential tissue pools were taken from retina, optic nerve, superior colliculus (SC), dorsal lateral geniculate nucleus (dLGN), visual cortex and cerebellum. The infectivity levels in these pools were estimated by intracerebral (i.c.) assay in C57BL/FaBtDk mice. Infectivity was first detected in retina at 35 days post-injection (as an increase above residual injected inoculum), SC at 56 days, dLGN at 77 days and in optic nerve, visual cortex and cerebellum at 98 days. Pathological lesions were shown to develop in the same sequence later in the incubation period. Comparison of sequential retina and SC assays in congenic mice, which differ only in the vicinity of the Sinc locus, revealed a difference in the initial detection and progression of i.o. infection of between 60 and 100 days, indicating that Sinc acts by delaying the initiation of replication. Higher levels of infectivity were found in retina and SC of mice infected with 79A scrapie, which destroys the photoreceptor layer in the retina, than with ME7 scrapie, which does not. Retrograde transport of infection was indicated by the levels of infectivity in the retina after i.c. infection with ME7 or 79A scrapie. These results indicate that scrapie spread within the central nervous system is restricted to neuroanatomical pathways, and that Sinc controls the initiation, but not the rate of replication.
Individual Differences in Foveal Shape: Feasibility of Individual Maps Between Structure and Function Within the Macular Region.

PURPOSE Recently in glaucoma, different mapping schemes to combine structural and functional information within the macula have been proposed. This paper aims to investigate whether the changes in foveal shape parameters are important in the mapping between structure and function within the macular region. METHODS Twenty younger adults (aged 24- to 33-years old) and 10 older adults (aged 62- to 76-years old) participated. On each subject, four foveally-centered radial spectral-domain optical coherence tomography (SD-OCT) scans with 45° of separation between each scan were acquired. After scan acquisition, foveal shape was extracted by fitting a previously proposed model that has been used to customize structure-function mapping in the macular region. Three parameters were obtained from the scans and then compared: the central thickness, the maximum thickness, and the radius. RESULTS There were significant differences in the foveal shape parameters between subjects. There was no main effect of the scan axis for the central thickness; however, there was an interaction between the scan axis and maximum thickness and between the scan axis and radius. With respect to the effect of age, we did not find a main effect for the central thickness, the maximum thickness or the radius, although this parameter approached statistical significance. CONCLUSIONS In our study, we demonstrated that the foveal shape is different for different subjects, but predictable superiorly and inferiorly within an individual. Our study highlights features important for the development of individually customized structure-function maps for the investigation of glaucomatous damage in the macular region.
Intrusion Detection in Wireless Ad-Hoc Networks

This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted , or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Intrusion detection in wireless ad-hoc networks / editors, Nabendu Chaki and Rituparna Chaki. pages cm Includes bibliographical references and index. Contents Preface ix a b o u t t h e e d i t o r s xi c o n t r i b u t o r s xiii chaP t e r 1 intro d u c t i o n 1 Nova ru N De b , M a N a l i CH a k r a bor T y, a N D N a beN Du CH a k i chaP t e r 2 a r c h i t e c t u r e a n d o r g a n i z at i o n is s u e s 43 M a N a l i CH a k r a bor T y, Nova ru N De b , De bDu T Ta ba r M a N roy, a N D r i T u pa r N a CH a k i chaP t e r 3 routin g f o r …
Fractionated Therapy of HER2-Expressing Breast and Ovarian Cancer Xenografts in Mice with Targeted Alpha Emitting 227Th-DOTA-p-benzyl-trastuzumab

Background The aim of this study was to investigate therapeutic efficacy and normal tissue toxicity of single dosage and fractionated targeted alpha therapy (TAT) in mice with HER2-expressing breast and ovarian cancer xenografts using the low dose rate radioimmunoconjugate 227Th-DOTA-p-benzyl-trastuzumab. Methodology/Principal Findings Nude mice carrying HER2-overexpressing subcutaneous SKOV-3 or SKBR-3 xenografts were treated with 1000 kBq/kg 227Th-trastuzumab as single injection or four injections of 250 kBq/kg with intervals of 4–5 days, 2 weeks, or 4 weeks. Control animals were treated with normal saline or unlabeled trastuzumab. In SKOV-3 xenografts tumor growth to 10-fold size was delayed (p<0.01) and survival with tumor diameter less than 16 mm was prolonged (p<0.05) in all TAT groups compared to the control groups. No statistically significant differences were seen among the treated groups. In SKBR-3 xenografts tumor growth to 10-fold size was delayed in the single injection and 4–5 days interval groups (p<0.001) and all except the 4 weeks interval TAT group showed improved survival to the control groups (p<0.05). Toxicity was assessed by blood cell counts, clinical chemistry measurements and body weight. Transient reduction in white blood cells was seen for the single injection and 4–5 days interval groups (p<0.05). No significant changes were seen in red blood cells, platelets or clinical chemistry parameters. Survival without life threatening loss of body weight was significantly prolonged in 4 weeks interval group compared to single injection group (p<0.05) for SKOV-3 animals and in 2 weeks interval group compared with the 4–5 days interval groups (p<0.05) for SKBR-3 animals. Conclusions/Significance The same concentration of radioactivity split into several fractions may improve toxicity of 227Th-radioimmunotherapy while the therapeutic effect is maintained. Thus, it might be possible to increase the cumulative absorbed radiation dose to tumor with acceptable toxicity by fractionation of the dosage.
Continuous Peripheral Nerve Blocks at Home: A Review

Postoperative analgesia is generally limited to 12–16 h or less after single-injection regional nerve blocks. Postoperative analgesia may be provided with a local anesthetic infusion via a perineural catheter after initial regional block resolution. This technique may now be used in the outpatient setting with the relatively recent introduction of reliable, portable infusion pumps. In this review article, we summarize the available published data related to this new analgesic technique and highlight important issues related specifically to perineural infusion provided in patients’ own homes. Topics include infusion benefits and risks, indications and patient selection criteria, catheter, infusion pump, dosing regimen, and infusate selection, and issues related specifically to home-care.
Maturation of Mismatch Negativity: A Scalp Current Density Analysis

Objective Auditory evoked potentials provide the opportunity to better understand the central processing of auditory stimuli, which is the basis of speech and language perception. The purpose of this study was to examine maturational changes in the topography of one of these auditory evoked potentials, the mismatch negativity (MMN), using scalp current density (SCD) analysis. Design Subjects were children ages 4 to 11 yr (N = 53), and adults (N = 12). Stimuli were 85 dB peSPL 1000 Hz standard tones and 1200 Hz deviant tones (deviant probability = 0.15). Auditory evoked potentials were recorded using surface electrodes placed at 32 locations on the head while subjects ignored the stimuli by watching a silent video. Results Significant maturational changes in topography of MMN were seen over frontal and left lateral sites. Conclusions Differences in MMN for the children compared to adults indicate that the MMN generators or their orientation, and thus the neural processes underlying discrimination of simple tones, are not yet mature by 11 yr of age.
Thermodynamic Description of Strain-Induced Crystallization of Natural Rubber by a Combination of the Tube Model and a Scaling Argument

The addition of nanoparticles remarkably improves the mechanical properties and strain-induced crystallizability of natural rubber. To reveal the underlying mechanism for the enhancement of these physical properties, we analyzed the microstructural changes of rubber due to the inclusion of clay and carbon black by using the tube model. The rubber filled with clay exhibited a stronger confinement effect of entanglements on the chain conformation compared with the pure rubber and that filled with carbon black. As a result, we propose a new thermodynamic approach to the entropic elasticity of entangled rubber by a combination of the blob scaling argument and the tube model. The thermodynamic analysis demonstrated that the restriction effects of both entanglements and the filler network led to a reduction of the conformational entropy in clay-filled rubber, resulting in the decrease of the onset strain of crystallization. These results revealed the mechanism of the strain-induced crystallization and filler reinforcement from the viewpoint of thermodynamics.
SNP@Ethnos: a database of ethnically variant single-nucleotide polymorphisms

Inherited genetic variation plays a critical but largely uncharacterized role in human differentiation. The completion of the International HapMap Project makes it possible to identify loci that may cause human differentiation. We have devised an approach to find such ethnically variant single-nucleotide polymorphisms (ESNPs) from the genotype profile of the populations included in the International HapMap database. We selected ESNPs using the nearest shrunken centroid method (NSCM), and performed multiple tests for genetic heterogeneity and frequency spectrum on genes having ESNPs. The function and disease association of the selected SNPs were also annotated. This resulted in the identification of 100 736 SNPs that appeared uniquely in each ethnic group. Of these SNPs, 1009 were within disease-associated genes, and 85 were predicted as damaging using the Sorting Intolerant From Tolerant system. This study resulted in the creation of the SNP@Ethnos database, which is designed to make this type of detailed genetic variation approach available to a wider range of researchers. SNP@Ethnos is a public database of ESNPs with annotation information that currently contains 100 736 ESNPs from 10 138 genes, and can be accessed at and or directly at .
T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence

Infections with monkeypox, cowpox and weaponized variola virus remain a threat to the increasingly unvaccinated human population, but little is known about their mechanisms of virulence and immune evasion. We now demonstrate that B22 proteins, encoded by the largest genes of these viruses, render human T cells unresponsive to stimulation of the T cell receptor by MHC-dependent antigen presentation or by MHC-independent stimulation. In contrast, stimuli that bypass TCR-signaling are not inhibited. In a non-human primate model of monkeypox, virus lacking the B22R homologue (MPXVΔ197) caused only mild disease with lower viremia and cutaneous pox lesions compared to wild type MPXV which caused high viremia, morbidity and mortality. Since MPXVΔ197-infected animals displayed accelerated T cell responses and less T cell dysregulation than MPXV US2003, we conclude that B22 family proteins cause viral virulence by suppressing T cell control of viral dissemination.
Uniquely presented finitely generated commutative monoids

A finitely generated commutative monoid is uniquely presented if it has a unique minimal presentation. We give necessary and sufficient conditions for finitely generated, combinatorially finite, cancellative, commutative monoids to be uniquely presented. We use the concept of gluing to construct commutative monoids with this property. Finally, for some relevant families of numerical semigroups we describe the elements that are uniquely presented.