Miracle-dz/UniFAR-FTUs huggingface dataset:
Stabilization in probability of nonlinear stochastic systems with guaranteed region of attraction and target set

We deal with nonlinear dynamical systems, consisting of a linear nominal part perturbed by model uncertainties, nonlinearities and both additive and multiplicative random noise, modeled as a Wiener process. In particular, we study the problem of finding suitable measurement feedback control laws such that the resulting closed-loop system is stable in some probabilistic sense. To this aim, we introduce a new notion of stabilization in probability, which is the natural counterpart of the classical concept of regional stabilization for deterministic nonlinear dynamical systems and stands as an intermediate notion between local and global stabilization in probability. This notion requires that, given a target set, a trajectory, starting from some compact region of the state space containing the target, remains forever inside some larger compact set, eventually enters any given neighborhood of the target in finite time and remains thereinafter, all these events being guaranteed with some probability. We give a Lyapunov-based sufficient condition for achieving stability in probability and a separation result which splits the control design into a state feedback problem and a filtering problem. Finally, we point out constructive procedures for solving the state feedback and filtering problem with arbitrarily large region of attraction and arbitrarily small target for a wide class of nonlinear systems, which at least include feedback linearizable systems. The generality of the result is promising for applications to other classes of stochastic nonlinear systems. In the deterministic case, our results recover classical stabilization results for nonlinear systems.
Modeling for Gellan Gum Production by Sphingomonas paucimobilis ATCC 31461 in a Simplified Medium

ABSTRACT Gellan gum production was carried out by Sphingomonas paucimobilis ATCC 31461 in a simplified medium with a short incubation time, and a kinetic model for understanding, controlling, and optimizing the fermentation process was proposed. The results revealed that glucose was the best carbon source and that the optimal concentration was 30 g liter−1. As for the fermenting parameters, considerably large amounts of gellan gum were yielded by an 8-h-old culture and a 4% inoculum at 200 rpm on a rotary shaker. Under the optimized conditions, the maximum level of gellan gum (14.75 g liter−1) and the highest conversion efficiency (49.17%) were obtained in a 30-liter fermentor in batch fermentation. Logistic and Luedeking-Piret models were confirmed to provide a good description of gellan gum fermentation, which gave some support for the study of gellan gum fermentation kinetics. Additionally, this study is the first demonstration that gellan gum production is largely growth associated by analysis of kinetics in its batch fermentation process. Based on model prediction, higher gellan gum production (17.71 g liter−1) and higher conversion efficiency (57.12%) were obtained in fed-batch fermentation at the same total glucose concentration (30 g liter−1).
National, Regional, and State Abusive Head Trauma: Application of the CDC Algorithm

OBJECTIVE: To examine national, regional, and state abusive head trauma (AHT) trends using child hospital discharge data by applying a new coding algorithm developed by the Centers for Disease Control and Prevention (CDC). METHODS: Data from 4 waves of the Kids’ Inpatient Database and annual discharge data from North Carolina were used to determine trends in AHT incidence among children <1 year of age between 2000 and 2009. National, regional, and state incidence rates were calculated. Poisson regression analyses were used to examine national, regional, and state AHT trends. RESULTS: The CDC narrow and broad algorithms identified 5437 and 6317 cases, respectively, in the 4 years of KID weighted data. This yielded average annual incidences of 33.4 and 38.8 cases per 100 000 children <1 year of age. There was no statistically significant change in national rates. There were variations by region of the country, with significantly different trends in the Midwest and West. State data for North Carolina showed wide annual variation in rates, with no significant trend. CONCLUSIONS: The new coding algorithm resulted in the highest AHT rates reported to date. At the same time, we found large but statistically insignificant annual variations in AHT rates in 1 large state. This suggests that caution should be used in interpreting AHT trends and attributing changes in rates as being caused by changes in policies, programs, or the economy.
Diabetes prevalence and its risk factors in urban Pondicherry

The present study was conducted in the Urban Health centre, Muthialpet, Pondicherry covering a population of 40000 from July to October 2007 by using a predesigned and pretested proforma to find out the risk of diabetes in general population by using Indian Diabetes Risk Score. A total of 616 respondents were studied comprising 325(53%) females and 290(47%) males. Majority 518(85%) were Hindus. Of them, 380 (62 %) had studied up to higher secondary and above, 539 (87%) belonged to upper middle and upper socioeconomic class. A large number of the subjects 422(68%) were above 35 years of age. Most of the respondents 558(90.50%) indulged in mild to moderate physical activity. Again, 422 (68.50%) had no family history of diabetes mellitus, 315 (51%) individuals were in the overweight category (>25 BMI), and 261 (83%) of high Diabetic Risk Score individuals were overweight. It is observed that chances of high diabetic score increase with the increase in BMI. Prevalence of diabetes in the studied population were 51 (8.27%), out of that 39 (76%) had high (>60) IDRS score. The relationship between BMI and IDRS shows that if BMI increases from under weight (<18.50) to obesity (>30) chances of risk for diabetes also increases significantly.
Lymph node distribution and pattern of metastases in the mesorectum following total mesorectal excision using the modified fat clearing technique

Aim To define the distribution, size, location and metastasis of lymph nodes (LNs) within the mesorectum from rectal cancer specimens following total mesorectal excision (TME) surgery without neoadjuvant therapy. Methods Specimens from 60 patients who underwent TME were treated with modified fat clearing solution to retrieve LNs. The mesorectum was divided into right lateral, anterior, posterior and left lateral sides, which were further subdivided into three levels (upper, middle and lower). Results 1436 LNs were harvested, including 985 small LNs (<5 mm in size). The number of LNs from the anterior, posterior and bilateral mesorectum was 125 (8.7%), 696 (48.5%) and 615 (42.8%), respectively. In the longitudinal axis, the difference in distribution at the three levels was not significant. 200 LN metastases (mLNs) were detected in 33 patients. 48% (96/200) of these were small LNs. More mLNs, especially small LNs, were shown in the more advanced T stage patients. The mLN metastasis rate was not influenced by tumour level. Conclusion Small LN detection increased the accuracy of N staging by 20% in this study. The incidence of metastasis was the same among the anterior, bilateral and posterior areas of the mesorectum. An increased incidence of mLN metastasis in small LNs was associated with more advanced T staging. mLN metastasis rates in both middle and low rectal cancer were higher in the distal mesorectum than that in the proximal mesorectum. LN number and density were not consistent with spread of the primary tumour. Distal mLNs were found in 35% of cases of both middle and distal rectal cancer, implying a need for TME in both.
CONSRANK: a server for the analysis, comparison and ranking of docking models based on inter-residue contacts

SUMMARY Herein, we present CONSRANK, a web tool for analyzing, comparing and ranking protein-protein and protein-nucleic acid docking models, based on the conservation of inter-residue contacts and its visualization in 2D and 3D interactive contact maps. AVAILABILITY AND IMPLEMENTATION CONSRANK is accessible as a public web tool at https://www.molnac. unisa.it/BioTools/consrank/. CONTACT romina.oliva@uniparthenope.it.
Leptin and Reproductive Function in Males

Leptin is a circulating protein produced by adipocytes that has been implicated in control of body weight through appetite regulation and control of reproduction, most likely through an effect on the central nervous system. From studies in mice, it is clear that the genetic background of the animal on which the mutation in the leptin gene is placed can influence how that mutation is expressed. Although the effects of leptin have been more thoroughly documented in nonprimate species than in primates, a few human families with genetic mutations of the gene for leptin or the leptin receptor show obesity and impaired fertility. There is conflicting evidence regarding the effects of leptin in male primates, but it appears that the metabolic and reproductive effects of low leptin levels caused by reduced energy intake in adult animals can be more readily alleviated by administration of energy substrates than by administration of leptin.
Patterns and Features of Families of Traveling Waves in Large-Scale Neuronal Networks

We study traveling wave solutions of a system of integro‐differential equations which describe the activity of large‐scale networks of excitatory neurons on spatially extended domains. The independent variables are the activity level u of a population of excitatory neurons, which have long range connections, and a recovery variable v. We have found a critical value of the parameter β ($\beta_* > 0$) that appears in the equation for v, at which the eigenvalues of the linearization of the system around the rest state $(u,v)=(0,0)$ change from real to complex. In contrast to previous studies which analyzed properties of traveling waves when the eigenvalues are real, we examine the range $\beta > \beta_*$, where the eigenvalues are complex. In this case we show that there is a range of parameters over which families of wave fronts and 1‐pulse and more general N‐pulse waves can coexist as stable solutions. In two space dimensions our numerical experiments show how single‐ring and multiring waves form in respon.
The Effects of Mild Ocular Surface Stimulation and Concentration on Spontaneous Blink Parameters

Abstract Purpose: This exploratory, pilot study compared the effects of concentrating on a visual task and a very mild ocular surface air stimulus on multiple blink parameters. Methods: Ten subjects participated in this study. There were two visits, one with an ocular surface air stimulus (AS) and one without (NS). The AS was set at a level barely perceptible by subjects (approximately 0.6 m/s at the eye). At each visit, subjects performed a high-concentration (HC) and low-concentration (LC) task. Blinking was tracked and tear-film breakup (TBU) was monitored simultaneously to measure blink parameters, including the interblink interval (IBI), blink amplitude, duration, maximum velocity and TBU before and after each blink. Results: During the HC tasks, IBI was significantly higher and blink duration was lower (repeated measures ANOVA, p < 0.05) than the LC tasks. The IBI in the AS-LC condition was significantly lower and less variable than in the NS-HC condition, whereas blink duration showed the opposite effect (Hotelling T2 test, p < 0.005). There was high individual variation in correlations between blink amplitude and maximum velocity. The area of TBU was not significantly correlated with any blink parameter. Conclusions: The lack of correlation between TBU and blinking suggests that many blinks are stimulated by internal controls, rather than direct stimulation of the ocular surface by TBU. This pilot study suggests that even very mild ocular surface stimulation produces opposite effects on the timing and duration of the blink, when compared to concentrating on a visual task. The HC task tends to decrease blink frequency and duration, presumably to minimize interruption by the eyelids, whereas mild ocular surface AS increased blink frequency and duration, most likely to increase protection of the ocular surface.
In Trans Complementation of Lethal Factor Reveal Roles in Colonization and Dissemination in a Murine Mouse Model

Lethal factor (LF) is a component of the B. anthracis exotoxin and critical for pathogenesis. The roles of LF in early anthrax pathogenesis, such as colonization and dissemination from the initial site of infection, are poorly understood. In mice models of infection, LF-deficient strains either have altered dissemination patterns or do not colonize, precluding analysis of the role of LF in colonization and dissemination from the portal of entry. Previous reports indicate rabbit and guinea pig models infected with LF-deficient strains have decreased virulence, yet the inability to use bioluminescent imaging techniques to track B. anthracis growth and dissemination in these hosts makes analysis of early pathogenesis challenging. In this study, the roles of LF early in infection were analyzed using bioluminescent signature tagged libraries of B. anthracis with varying ratios of LF-producing and LF-deficient clones. Populations where all clones produced LF and populations where only 40% of clones produce LF were equally virulent. The 40% LF-producing clones trans complimented the LF mutants and permitted them to colonize and disseminate. Decreases of the LF producing strains to 10% or 0.3% of the population led to increased host survival and decreased trans complementation of the LF mutants. A library with 10% LF producing clones could replicate and disseminate, but fewer clones disseminated and the mutant clones were less competitive than wild type. The inoculum with 0.3% LF producing clones could not colonize the host. This strongly suggests that between 10% and 0.3% of the population must produce LF in order to colonize. In total, these findings suggest that a threshold of LF must be produced in order for colonization and dissemination to occur in vivo. These observations suggest that LF has a major role in the early stages of colonization and dissemination.
Preparation and Characterization of Co-grinding Tablet of Meloxicam with PVP K-30

Preparation of tablets dosage form from co-grinding of meloxicam with PVP K-30 has been done. Meloxicam and PVP K-30 in a weight ratio of 1:3 were grounded for 2 hours. The interaction of co-grinding solids state were evaluated by FT-IR. Tablets were prepared by direct compression method in three formulas: co-grinding of meloxicam (F1), physical mixtures meloxicam (F2), and intact meloxicam tablet (F3). The evaluations conducted for tablets were weight variation, size variation, hardness test, friability test, disintegration time, and tablet dissolution. Dissolution test was carried out for 60 minutes in phosphate buffer pH 7.5. The dissolution test results for F1, F2, and F3, were 71.65% ± 2.32; 51.66% ± 5.38; 35.71% ± 2.96, respectively. Co-grinding meloxicam tablet showed the highest dissolution rate compared to physical mixture and intact meloxicam tablet (p<0.05).
Enhancing the performance of Sn-Ag-Cu solder with the addition of titanium diboride particulates

In this study, varying volume percentage of titanium diboride particulates were successfully incorporated into Sn-Ag-Cu solder, to synthesize lead-free composite solders. The composite solders were synthesized via the powder metallurgy route of: blending, compaction, sintering and extrusion. The extruded materials were then characterized for their microstructural development, thermal and mechanical properties. With increasing volume percentage of titanium diboride particulates, the composite solders experienced a corresponding decrease in density values but porosity levels were observed to increase. Microstructural characterization using scanning electron microscopy revealed uniform distribution of reinforcement particulates and a fairly good interfacial integrity between the particulates and the solder matrix. Thermomechanical analysis showed that presence of titanium diboride particulates as reinforcements, decreased the average coefficient of thermal expansion of the solder composites. A change in the mechanical properties was also observed with the presence of increasing particulates. An attempt is made, to correlate the increasing presence of titanium diboride particulates with the microstructural development, as well as the mechanical and thermal properties of solder matrix.Copyright © 2004 by ASME
An Open-Source and Low-Cost Monitoring System for Precision Enology

Winemaking is a dynamic process, where microbiological and chemical effects may strongly differentiate products from the same vineyard and even between wine vats. This high variability means an increase in work in terms of control and process management. The winemaking process therefore requires a site-specific approach in order to optimize cellar practices and quality management, suggesting a new concept of winemaking, identified as Precision Enology. The Institute of Biometeorology of the Italian National Research Council has developed a wireless monitoring system, consisting of a series of nodes integrated in barrel bungs with sensors for the measurement of wine physical and chemical parameters in the barrel. This paper describes an open-source evolution of the preliminary prototype, using Arduino-based technology. Results have shown good performance in terms of data transmission and accuracy, minimal size and power consumption. The system has been designed to create a low-cost product, which allows a remote and real-time control of wine evolution in each barrel, minimizing costs and time for sampling and laboratory analysis. The possibility of integrating any kind of sensors makes the system a flexible tool that can satisfy various monitoring needs.
School of pharmacy-based medication therapy management program: development and initial experience.

OBJECTIVE To describe a school of pharmacy-community pharmacy collaborative model for medication therapy management (MTM) service and training. SETTING University of Washington (UW) School of Pharmacy (Seattle), from July to December 2008. PRACTICE DESCRIPTION MTM services and training. PRACTICE INNOVATION A campus-based MTM pharmacy was established for teaching, practice, and collaboration with community pharmacies to provide comprehensive medication reviews (CMRs) and MTM training. MAIN OUTCOME MEASURES Number of collaborating pharmacies, number of patients contacted, number of CMRs conducted, and estimated cost avoidance (ECA). RESULTS UW Pharmacy Cares was licensed as a Class A pharmacy (nondispensing) and signed "business associate" agreements with six community pharmacies. During July to December 2008, 10 faculty pharmacists completed training and 5 provided CMR services to 17 patients (5 telephonic and 12 face-to-face interviews). A total of 67 claims (17 CMRs and 50 CMR-generated claims) were submitted for reimbursement of $1,642 ($96.58/CMR case). Total ECA was $54,250, averaging $3,191.19 per patient. Seven student pharmacists gained CMR interview training. CONCLUSION Interest in collaboration by community pharmacies was lower than expected; however, the campus-community practice model addressed unmet patient care needs, reduced outstanding MTM CMR case loads, increased ECA, and facilitated faculty development and training of student pharmacists.
Universality, Characteristic Kernels and RKHS Embedding of Measures

Over the last few years, two different notions of positive definite (pd) kernels---universal and characteristic---have been developing in parallel in machine learning: universal kernels are proposed in the context of achieving the Bayes risk by kernel-based classification/regression algorithms while characteristic kernels are introduced in the context of distinguishing probability measures by embedding them into a reproducing kernel Hilbert space (RKHS). However, the relation between these two notions is not well understood. The main contribution of this paper is to clarify the relation between universal and characteristic kernels by presenting a unifying study relating them to RKHS embedding of measures, in addition to clarifying their relation to other common notions of strictly pd, conditionally strictly pd and integrally strictly pd kernels. For radial kernels on ℜd, all these notions are shown to be equivalent.
Visual Field Map Clusters in Macaque Extrastriate Visual Cortex

The macaque visual cortex contains >30 different functional visual areas, yet surprisingly little is known about the underlying organizational principles that structure its components into a complete “visual” unit. A recent model of visual cortical organization in humans suggests that visual field maps are organized as clusters. Clusters minimize axonal connections between individual field maps that represent common visual percepts, with different clusters thought to carry out different functions. Experimental support for this hypothesis, however, is lacking in macaques, leaving open the question of whether it is unique to humans or a more general model for primate vision. Here we show, using high-resolution blood oxygen level-dependent functional magnetic resonance imaging data in the awake monkey at 7 T, that the middle temporal area (area MT/V5) and its neighbors are organized as a cluster with a common foveal representation and a circular eccentricity map. This novel view on the functional topography of area MT/V5 and satellites indicates that field map clusters are evolutionarily preserved and may be a fundamental organizational principle of the Old World primate visual cortex.
Genomic fingerprinting of Mycobacterium bovis from cattle by restriction fragment length polymorphism analysis

Two insertion sequences, IS6110 and IS1081, specific to the tuberculosis complex mycobacteria and a highly reiterated DNA element (pTBN12) cloned from Mycobacterium tuberculosis were systematically used to identify restriction fragment length polymorphism (RFLP) types among bovine isolates of Mycobacterium bovis in Northern Ireland. In a sample of 109 isolates, probes IS6110, IS1081, and pTBN12 identified 10, 2, and 12 distinct patterns, respectively. By combining the patterns generated by the three probes it was possible to identify 28 distinct RFLP types. The standard protocol advocated for RFLP analysis of M. tuberculosis was used and would facilitate computer-based gel documentation and image analysis to establish a database of M. bovis types for large-scale epidemiological studies. These procedures will facilitate interlaboratory comparisons of M. bovis isolates and will help to elucidate the precise epidemiology of bovine tuberculosis in different countries.