Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of MALAT1 as a Prognostic Factor for Survival in Various Cancers: A Systematic Review of the Literature with Meta-Analysis

Objectives. The expression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a highly abundant and ubiquitously expressed long noncoding RNA (lncRNA), influences clinical parameters and may have prognostic value in cancer. This meta-analysis evaluated the prognostic role of MALAT1 in various cancers. Materials and Methods. Systematic literature searches of PubMed and EMBASE databases were conducted for eligible studies of the prognostic role of MALAT1 in cancer. Overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were analyzed. Summary hazard ratios (HRs) and 95% confidence intervals (95% CIs) were assessed to evaluate the influence of MALAT1 expression on patient prognosis. Results. Nine studies with a total of 932 patients were included in the analysis. Elevated MALAT1 expression was significantly correlated with poor OS (HR 2.02; 95% CI: 1.62–2.52; P < 0.001; I 2 = 0%). Subgroup analysis indicated that tumor type, histology type, ethnicity, and measurement technique did not affect the prognostic value of MALAT1 for OS. The HR of elevated MALAT1 for DFS was 2.78 (95% CI: 1.87–4.15; P < 0.001; I 2 = 0%). Conclusions. Elevated MALAT1 expression is correlated with poor OS in various types of cancer, suggesting that this gene is a prognostic factor for different types of cancer.
Do older adults underestimate their actual computer knowledge?

This work examined the hypothesis that elderly people are less confident than young people in their own computer knowledge. This was done by having 49 young (M = 22.6 years) and 42 older (M = 68.6 years) participants to assess their global self-efficacy beliefs and to make item-by-item prospective (feeling-of-knowing: FOK) and retrospective (confidence level: CL) judgments about their knowledge in the two domains of computers and general knowledge. The latter served as a control domain. Item difficulty was equated across age groups in each domain. In spite of this age equivalence in actual performance, differences were found in FOK and CL ratings for computers but not for general knowledge, with older people being less confident than young people in their own computer knowledge. The greater age difference in ratings observed in the computer domain, as compared with the general domain, was even greater for the FOK than for the CL judgments. Statistical control of age differences in global self-efficacy beliefs in the computer domain (poorer in the older participants, but not in the general domain), eliminated age differences in FOK and CL judgments in the same domain. These findings confirm earlier ones. They suggest that underconfidence in their relevant abilities is one possible source of the difficulties that the elderly may encounter in mastering new computer technologies.
Asia-Pacific Thrombosis Advisory Board consensus paper on prevention of venous thromboembolism after major orthopaedic surgery

Summary The incidence of postoperative venous thromboembolism (VTE) in Asian populations is generally thought to be lower than in Western populations, and the use of thromboprophylaxis after surgery is not routine. This paper is authored by the Asia-Pacific Thrombosis Advisory Board. To provide guidance on the most effective postoperative thrombo prophylaxis management, this paper reviews the available data on the incidence of VTE in Asian populations, considers current clinical guidelines for the prevention of VTE to determine whether these guidelines are applicable to Asian populations, and evaluates the potential of new thromboprophylactic agents. Based on the available evidence, it was agreed that VTE represents a genuine problem in Asian patients, although the exact incidence in local populations requires confirmation in large, well-designed clinical trials. Furthermore, there was consensus that current guideline recommendations for the routine use of postoperative thromboprophylaxis should be implemented in Asia, and that new oral agents now available represent an effective and potentially more convenient therapeutic option. In conclusion, we call for recognition that VTE is an issue in Asian patients, and that effective thromboprophylaxis is the most important strategy.
Physical Carrier Sense in Vehicular Ad-Hoc Networks

Enhancing road safety using vehicle-to-vehicle communication has become an important goal for the automotive industry. A lot of effort has been put in the design of an efficient medium access control protocol, capable to function correctly even under heavy congestion. The solutions proposed so far focus on data rate or transmission power control. In this paper, we argue that the most important parameter for congestion control in vehicular ad hoc networks is the carrier sense threshold. We support this theory with analytical and simulation results and we demonstrate that the optimal threshold depends on the vehicular density. Furthermore, we propose an adaptive mechanism for physical carrier sense control and analyse its performance, showing an important increase in message reception probability.
Perceived causes of initial development and relapses in anorexia nervosa: A comparison to theoretical models of aetiology

Anorexia nervosa is a disorder which causes significant impairment, both acute and chronic, for those who experience it. Anorexia nervosa is associated with a long-term course and high rates of relapse. The purpose of this research was to investigate the perspectives of those with anorexia nervosa on aetiology and their views on causes of relapse. The aim was to gain a better understanding of how those with anorexia nervosa conceptualise it; compare it to theoretical models and considered how these perceptions may relate to treatment. Sixteen semi-structured interviews were conducted with eight participants, consisting of eight initial interviews, then eight follow-up interviews to reflect on preliminary findings. Findings related to three main domains: definitions of anorexia nervosa, causes of initial development, and causes of subsequent episodes (relapses). Individual and collective definitions of anorexia nervosa were markedly different from diagnostic definitions, mainly due to the increased detail but there was also contention around how diagnostic definitions focus on body image and resistance to recovery. Causes of anorexia nervosa in this study matched other in-depth research of accounts, but varied with respect to aetiological models. A key difference uncovered in this study was the emphasis placed by participants on different aspects of anorexia, which fell outside of weight and body image concerns, and notable that these aspects became a part of the reasoning for anorexia. Perspectives on the causes of relapse indicated three main categories: those which were present during initial development, those which were present during the initial development but only became significant after experiencing anorexia, and those which were unique to relapse. Due to the limited research in this area it was challenging to compare these findings to other studies; however, they do represent an important aspect of treatment and research, which could be enhanced. A model of aetiology of anorexia nervosa was developed integrating current findings with established theoretical models and research; key influences contributing to relapse were also modelled. Relevant recommendations for diagnosis, treatment, and relapse prevention are presented throughout the discussion.
A General Framework for Estimating Graphlet Statistics via Random Walk

Graphlets are induced subgraph patterns and have been frequently applied to characterize the local topology structures of graphs across various domains, e.g., online social networks (OSNs) and biological networks. Discovering and computing graphlet statistics are highly challenging. First, the massive size of real-world graphs makes the exact computation of graphlets extremely expensive. Secondly, the graph topology may not be readily available so one has to resort to web crawling using the available application programming interfaces (APIs). In this work, we propose a general and novel framework to estimate graphlet statistics of "any size". Our framework is based on collecting samples through consecutive steps of random walks. We derive an analytical bound on the sample size (via the Chernoff-Hoeffding technique) to guarantee the convergence of our unbiased estimator. To further improve the accuracy, we introduce two novel optimization techniques to reduce the lower bound on the sample size. Experimental evaluations demonstrate that our methods outperform the state-of-the-art method up to an order of magnitude both in terms of accuracy and time cost.
Multiple In Vitro Analyses of Fracture Resistance in Maxillary Central Incisors Restored with Fiber Posts

INTRODUCTION The resistance to fracture of endodontically treated teeth restored with esthetic post systems has not been extensively researched. This in vitro study compared the fracture patterns of endodontically treated teeth with esthetic post systems with different analysis methods. MATERIALS AND METHODS A total of 26 recently extracted human maxillary central incisors were decoronated and then endodontically treated. Teeth were restored with quartz fiber posts. All posts were cemented with Panavia dual curing adhesive resin cement and subsequently restored with composite cores. Three methods were used to test fracture resistance. Each specimen was embedded in acrylic resin and then secured in a universal load-testing machine. A compressive load was applied at 135º degree angle at a crosshead speed of 1 mm/min to the long axis of the tooth until fracture occurred. The two other methods, finite element analysis (FEA) and photo elastic study used the same angulation and 90 N force to simulate the first method. The data were then compared. RESULTS Clinical results indicated that fracture was most likely to occur between core and dentin, and then in the cervical 1/3 of the root. Photo elastic study demonstrated similar results; the highest stresses occurred at the junction of dentin and core contralateral to the side where force was applied. FEA also confirmed these results; however it also showed that the highest stresses arise at the dentin/core junction contralateral to the force point. CONCLUSION All three techniques reiterate that the risk of fracture is greatest at the cervical dentin/core junction.
Outgroup Favoritism and the Theory of System Justiﬁcation: A Paradigm for Investigating the Effects of Socioeconomic Success on Stereotype Content

Thought,”universitystudentsare told that they are aboutto participatein a researchprojectaimedat understanding“why differencesin social andeconomic successexistbetweengraduatesof differentcollegesand universities. ”Half of the participantsare presentedwith statisticsindicating that alumni membersof their own universitygroup aresignificantly lesssuccessfulin terms Whatthesedistinctbodiesof evidencehave in common
The Politics of Community: Theory and Practice

Introduction Chapter One: Theorising Community Chapter Two: Communitarianism and Liberalism: The Philosophical Debate Chapter Three: Political Communitarianism: Towards Moral Authoritarianism Chapter Four: Radical Theories of Community: Beyond Orthodox Communitarianism Chapter Five: Community and Economy: Rethinking Work? Chapter Six: Community and Society: The Implications for Social Policy Chapter Seven: Repoliticising Community: Towards Democratic Renewal Chapter Eight: Pluralism, Community and Civil Society Conclusion Bibliography.
The Effects of Brand Engagement in Social Media on Share of Wallet

Customer engagement and share-of-wallet (SOW) are relatively new in the marketing literature, and academic research has only limitedly examined these concepts. This study presents five motivational drivers of customer brand engagement in social media and examines the nature of the relationship between these drivers and engagement. The moderation effect of consumer innovativeness on the relationship between engagement and SOW is also examined. Results suggest that community exerts the strongest positive effect on customer brand engagement and that such engagement positively influences SOW. The findings also indicate that consumer innovativeness strengthens the relationship between engagement and SOW. The findings also show that frequency of visits on the brand community site predict higher SOW. This study contributes to the understanding of customer brand engagement by describing how online brand community engagement and its antecedents drive SOW.
Hopelessness and future thinking in parasuicide: the role of perfectionism.

OBJECTIVES This study had three aims: (1) to independently replicate the future thinking effect, that parasuicides, when compared with controls, show a deficit in positive future thinking but no increase in negative future thinking; (2) to determine whether positive future thinking and socially prescribed perfectionism discriminate general hospital parasuicides from controls beyond measures of affect and; (3) to explore the relationship between future thinking and perfectionism. DESIGN A cross-sectional design was employed. Three groups of participants took part: hospital parasuicide patients (N=22), hospital controls (N=22) and community controls (N=21). METHODS Parasuicide patients admitted, via accident and emergency, to a general hospital were matched with hospital and community controls and assessed on measures of hopelessness, depression, anxiety, perfectionism, and future thinking. RESULTS There was evidence to support the future thinking effect. A discriminant function analysis revealed that social perfectionism and positive future thinking did indeed discriminate parasuicides from controls beyond the effects of hopelessness, depression, and anxiety. Exploratory relationships between perfectionism and positive future thinking were also reported. CONCLUSIONS The results reinforce the importance of future thinking in parasuicide. Moreover, the role of social perfectionism in the suicidal process was elucidated and ought to be replicated within a prospective design.
Injuries of the Flexor Tendons: Focus on the Superficial Digital Flexor Tendon

Of the two flexor tendons in horses’ lower limbs, the superficial digital flexor tendon is more commonly injured than the deep digital flexor tendon. Flexor tendon injuries are caused by either overstrain of the tendon or direct trauma. Overstrain injuries have a typical swelling of the tendon that requires ultrasonographic evaluation to confirm the diagnosis. Treatment of these injuries includes anti-inflammatory therapy initially followed by a rehabilitation program. New therapies are emerging for modulating healing of these injuries. Flexor tendon lacerations are usually the result of direct penetrating trauma to the limb. Management of these injuries includes surgical management combined with appropriate coaptation. Involvement of a tendon sheath complicates management with the potential formation of septic tenosynovitis. The prognosis for returning successfully to athletic function in the case of overstrain injuries is fair, but re-injury is common, and for tendon lacerations, it is guarded to poor.
Clinical Predictors of Pneumonia Among Children With Wheezing

OBJECTIVE: The goal was to identify factors associated with radiographically confirmed pneumonia among children with wheezing in the emergency department (ED) setting. METHODS: A prospective cohort study was performed with children ≤21 years of age who were evaluated in the ED, were found to have wheezing on examination, and had chest radiography performed because of possible pneumonia. Historical features and examination findings were collected by treating physicians before knowledge of the chest radiograph results. Chest radiographs were read independently by 2 blinded radiologists. RESULTS: A total of 526 patients met the inclusion criteria; the median age was 1.9 years (interquartile range: 0.7–4.5 years), and 36% were hospitalized. A history of wheezing was present for 247 patients (47%). Twenty-six patients (4.9% [95% confidence interval [CI]: 3.3–7.3]) had radiographic pneumonia. History of fever at home (positive likelihood ratio [LR]: 1.39 [95% CI: 1.13–1.70]), history of abdominal pain (positive LR: 2.85 [95% CI: 1.08–7.54]), triage temperature of ≥38°C (positive LR: 2.03 [95% CI: 1.34–3.07]), maximal temperature in the ED of ≥38°C (positive LR: 1.92 [95% CI: 1.48–2.49]), and triage oxygen saturation of <92% (positive LR: 3.06 [95% CI: 1.15–8.16]) were associated with increased risk of pneumonia. Among afebrile children (temperature of <38°C) with wheezing, the rate of pneumonia was very low (2.2% [95% CI: 1.0–4.7]). CONCLUSIONS: Radiographic pneumonia among children with wheezing is uncommon. Historical and clinical factors may be used to determine the need for chest radiography for wheezing children. The routine use of chest radiography for children with wheezing but without fever should be discouraged.
Treatment of Gustilo grade III tibial fractures with unreamed intramedullary nailing versus external fixator: A meta-analysis

Summary Unreamed Intramedullary nailing and external fixation are 2 major treatments widely used in Gustilo grade III open tibial fractures, but the difference in effectiveness and complication remains controversial. We retrieved original publications of comparative studies from medical literature databases and selected 9 of them for a meta-analysis. Observation items include malunion and deep infection rate, non-union and comparison of time to union. The analysis showed a lower malunion rate using unreamed intramedullary nailing than external fixation. No significant differences were revealed in deep infection/nonunion rate and time to union. More studies of larger scale and better design are needed to reach an ultimate and definite conclusion.
Sex & gender : an introduction

PART I. MYTHS, THEORIES, AND RESEARCH 1. Masculinity & Femininity: Myths & Stereotypes 2. Theoretical Perspectives on Sex & Gender 3. Researching Sex & Gender: Exploring the Whys & Hows PART II. BEHAVIOR & EXPERIENCE: FEMALE--MALE SIMILARITIES & DIFFERENCES 4. World's Apart? Gender Differences in Social Behavior & Experience 5. Biology & Environment: The Process of Becoming Female or Male 6. Perceptual & Cognitive Abilities: Gender Similarities & Differences 7. Sexual Lives & Orientations 8. Hormonal & Reproductive Connections 9. Mental & Physical Health: Stress, Change, & Adaptations PART III. SEX & GENDER IN SOCIAL RELATIONSHIPS 10. Sex & Gender & Childhood: Constructing Gender 11. Family & Friends: Attachment, Intimacy, & Power 12. Economic & Political Life: Power, Status, & Achievement 13. Issues in the Workplace 14. Justice, Equity, & Social Change Epilogue: The Ties That Bind: The Future of Sex & Gender
An Empirical Evaluation of Four Algorithms for Multi-Class Classification: Mart, ABC-Mart, Robust LogitBoost, and ABC-LogitBoost

This empirical study is mainly devoted to comparing four tree-based boosting algorithms: mart, abc-mart, robust logitboost, and abc-logitboost, for multi-class classification on a variety of publicly available datasets. Some of those datasets have been thoroughly tested in prior studies using a broad range of classification algorithms including SVM, neural nets, and deep learning. In terms of the empirical classification errors, our experiment results demonstrate: 1. Abc-mart considerably improves mart. 2. Abc-logitboost considerably improves (robust) logitboost. 3. Robust) logitboost} considerably improves mart on most datasets. 4. Abc-logitboost considerably improves abc-mart on most datasets. 5. These four boosting algorithms (especially abc-logitboost) outperform SVM on many datasets. 6. Compared to the best deep learning methods, these four boosting algorithms (especially abc-logitboost) are competitive.
The positive effects of a protean career attitude for self‐initiated expatriates

Purpose – The authors sought to explain why and how protean career attitude might influence self‐initiated expatriates' (SIEs) experiences positively. A mediation model of cultural adjustment was proposed and empirically evaluated.Design/methodology/approach – Data from 132 SIEs in Germany containing measures of protean career attitude, cultural adjustment, career satisfaction, life satisfaction, and intention to stay in the host country were analysed using path analysis with a bootstrap method.Findings – Empirical results provide support for the authors' proposed model: the positive relations between protean career attitude and the three expatriation outcomes (career satisfaction, life satisfaction and intention to stay in the host country) were mediated by positive cross‐cultural adjustment of SIEs.Research limitations/implications – All data were cross‐sectional from a single source. The sample size was small and included a large portion of Chinese participants. The study should be replicated with samp.
development of heart failure cardiomyopathy : shared and distinct genes in the Gene expression analysis of ischemic and nonischemic

development of heart failure cardiomyopathy: shared and distinct genes in the Gene expression analysis of ischemic and nonischemic You might find this additional info useful. 24 times a year (twice monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD systems with techniques linking genes and pathways to physiology, from prokaryotes to eukaryotes. It is published publishes results of a wide variety of studies from human and from informative model Physiological Genomics
Recognition of objects and their component parts: responses of single units in the temporal cortex of the macaque.

We investigated the role that different component parts play in the neural encoding of the visual appearance of one complex object in the temporal cortex. Cells responsive to the sight of the entire human body (but no to control stimuli) were tested with two subregions (head alone with the body occluded from sight and the body alone with the head occluded). Forty-two percent (22 of 53) of cells responded to the whole body and to one of the two body regions tested separately: 72% (17 of 22) responding to the head and 28% (5 of 22) to the rest of the body. Forty-two percent (22 of 53) of cells responded independently to both regions of the body when tested in isolation. The remaining cells (17%, 9 of 53) were selective for the entire body and unresponsive to component parts. The majority of cells tested (90%, 35 of 39) were selective for perspective view (e.g., some cells respond optimally to the side view of the body, others to the back view). Comparable levels of view sensitivity were found for responses to the whole body and its parts. Results indicate (1) separate neuronal analysis of body parts and (2) extensive integration of information from different parts. Contrary to influential models of object recognition (Marr and Nishihara, 1978; Biederman, 1987), the results indicate view-specific processing both for the appearance of separate object components and for integration of information across components.