Miracle-dz/UniFAR-FTUs huggingface dataset:
Composite tube cracking in kraft recovery boilers: A state-of-the-art review

Beginning in the mid-1960s, increasing energy costs in Finland and Sweden made energy recovery more critical to the cost-effective operation of a kraft pulp mill. Boiler designers responded to this need by raising the steam operating pressure, but almost immediately the wall tubes in these new boilers began to corrode rapidly. Test panels installed in the walls of the most severely corroding boiler identified austenitic stainless steel as sufficiently resistant to the new corrosive conditions, and discussions with Sandvik AB, a Swedish tube manufacturer, led to the suggestion that coextruded tubes be used for water wall service in kraft recovery boilers. Replacement of carbon steel by coextruded tubes has solved most of the corrosion problems experienced by carbon steel wall tubes, however, these tubes have not been problem-free. Beginning in early 1995, a multidisciplinary research program funded by the US Department of Energy was established to investigate the cause of cracking in coextruded tubes and to develop improved materials for use in water walls and floors of kraft recovery boilers. One portion of that program, a state-of-the-art review of public- and private-domain documents related to coextruded tube cracking in kraft recovery boilers is reported here. Sources of information that were consulted for this review include the following: tube manufacturers, boiler manufacturers, public-domain literature, companies operating kraft recovery boilers, consultants and failure analysis laboratories, and failure analyses conducted specifically for this project. Much of the information contained in this report involves cracking problems experienced in recovery boiler floors and those aspects of spout and air-port-opening cracking not readily attributable to thermal fatigue. 61 refs.
Modeling and Design of Coated Stents to Optimize the Effect of the Dose

Stents are used in interventional cardiology to keep a diseased vessel open. New stents are coated with a medicinal agent to prevent early reclosure due to the proliferation of smooth muscle cells. It is recognized that it is the dose of the agent that effectively controls the cells in the wall of the vessel. This paper focuses on the effect of the number of struts and the ratio between the coated area of the struts and the targeted area of the vessel on the design problem under set therapeutic bounds on the dose. It introduces mathematical models of the dose for a zero-thickness periodic stent and an asymptotic stent that will playa central role in our analysis. Theoretical and numerical results are presented along with their impact on the design process.
Comparison of Cardiac Output Measurements in Critically Ill Patients: Flotrac/Vigileo Vs Transthoracic Doppler Echocardiography

Measurement of cardiac output is an integral part of patient management in the intensive care unit. FloTrac/Vigileo is a continuous cardiac output monitoring device that does not need re-calibration. However, its reliability has been questioned in some studies, especially involving surgical patients. In this study, we evaluated the comparability of FloTrac/Vigileo and transthoracic Doppler echocardiography in 53 critically ill patients requiring continuous cardiac output monitoring. Most of these patients had septic or cardiogenic shock. Cardiac output was measured by both FloTrac/Vigileo and transthoracic Doppler echocardiography. The bias and precision (mean and SD) between the two devices was 0.35±1.35 l/minute. The limits of agreement were -2.3 to 3.0 l/minute (%error=49.3%). When patients with irregular heart rhythms and aortic stenosis were excluded, the bias and precision was 0.02±0.80 l/minute (n=42). The limits of agreement were -1.55 to 1.59 l/minute (%error=29.5%). Patient demographics (body surface area, gender and age) did not affect the bias, but there was a mild tendency for FloTrac/Vigileo to register a higher cardiac output at high heart rates. Changes in cardiac output for two consecutive days correlated well between the two methods (r=0.86; P <0.001). In summary, with the exceptions of patients with irregular heart rhythms and significant aortic stenosis, FloTrac/Vigileo is clinically comparable to transthoracic Doppler echocardiography in cardiac output measurements in critically ill patients.
Cities and Systemic Change for Sustainability: Prevailing Epistemologies and an Emerging Research Agenda

Cities are key for sustainability and the radical systemic changes required to enable equitable human development within planetary boundaries. Their particular role in this regard has become the subject of an emerging and highly interdisciplinary scientific debate. Drawing on a qualitative literature review, this paper identifies and scrutinizes the principal fields involved, asking for their respective normative orientation, interdisciplinary constitution, theories and methods used, and empirical basis to provide orientations for future research. It recognizes four salient research epistemologies, each focusing on a distinct combination of drivers of change: (A) transforming urban metabolisms and political ecologies; (B) configuring urban innovation systems for green economies; (C) building adaptive urban communities and ecosystems; and (D) empowering urban grassroots niches and social innovation. The findings suggest that future research directed at cities and systemic change towards sustainability should (1) explore interrelations between the above epistemologies, using relational geography and governance theory as boundary areas; (2) conceive of cities as places shaped by and shaping interactions between multiple socio-technical and social-ecological systems; (3) focus on agency across systems and drivers of change, and develop corresponding approaches for intervention and experimentation; and (4) rebalance the empirical basis and methods employed, strengthening transdisciplinarity in particular.
What Can Be Done About School Bullying?

In this article, the authors review research on individual, peer, and school contributions that may be critical factors for enhancing efforts to address bullying among students. Methodological challenges are delineated, with an emphasis on how bullying is defined and assessed and the subsequent implications for bullying prevention and intervention program evaluation. The impact of school-based anti-bullying programs and the challenges currently facing educators and researchers in this area are discussed. The article concludes with a proposal for a broader, ecologically based model of school bullying based on the emerging literature.
Digestible valine requirements for broilers from 22 and 42 days old

Current experiment established different criteria to evaluate the requirements of digestible valine for broilers from 22 and 42 days of age, by different regression models (quadratic, exponential and Linear Response Plateau) and, in the case of statistical significance, the comparison of means by Duncan test at 5% probability. A total of 1,920 Cobb 500 male broilers were used and distributed in an entirely randomized experimental design, with 6 treatments (6 digestible valine levels: 0.7192, 0.7729, 0.8265, 0.8802, 0.9339 and 0.9876%) and 8 replications, with 40 broilers each. Data on performance and carcass characteristics were evaluated. The level of 0.8265% digestible valine was considered standard. The inclusion of 0.816, 0.848 and 0.903% of digestible valine levels, corresponding to digestible valine:lysine ratios of approximately 76.00%, 79.00% and 84.12%, provided best feed intake, weight gain and feed conversion ratio, respectively for broiler from 22 to 42 days of age.
Caper: automatic verification for fine-grained concurrency

Recent program logics based on separation logic emphasise a modular approach to proving functional correctness for ﬁne-grained concurrent programs. However, these logics have no automation support. In this paper, we present Caper , a prototype tool for automated reasoning in such a logic. Caper is based on symbolic execution, integrating reasoning about interference on shared data and about ghost resources that are used to mediate this interference. This enables Caper to verify the functional correctness of ﬁne-grained concurrent algorithms
Baculovirus Replication: Stimulation of Thymidine Kinase and DNA Polymerase Activities in Spodoptera frugiperda Cells Infected with Trichoplusia ni Nuclear Polyhedrosis Virus

Summary Trichoplusia ni multiply enveloped nuclear polyhedrosis virus stimulates thymidine kinase and DNA polymerase activities in infected cells. The kinetics of induction and sensitivity of induction to cytosine arabinoside indicate that they represent early functions in infected cells. The basic characteristics of the induced enzymes are defined.
ICAM-1-Targeted, Lcn2 siRNA-Encapsulating Liposomes are Potent Anti-angiogenic Agents for Triple Negative Breast Cancer

Lipocalin 2 (Lcn2) is a promising therapeutic target as well as a potential diagnostic biomarker for breast cancer. It has been previously shown to promote breast cancer progression by inducing the epithelial to mesenchymal transition in breast cancer cells as well as by enhancing angiogenesis. Lcn2 levels in urine and tissue samples of breast cancer patients has also been correlated with breast cancer status and poor patient prognosis. In this study, we have engineered a novel liposomal small interfering RNA (siRNA) delivery system to target triple negative breast cancer (TNBC) via a recently identified molecular target, intercellular adhesion molecule-1 (ICAM-1). This ICAM-1-targeted, Lcn2 siRNA- encapsulating liposome (ICAM-Lcn2-LP) binds human TNBC MDA-MB-231cells significantly stronger than non-neoplastic MCF-10A cells. Efficient Lcn2 knockdown by ICAM-Lcn2-LPs led to a significant reduction in the production of vascular endothelial growth factor (VEGF) from MDA-MB-231 cells, which, in turn, led to reduced angiogenesis both in vitro and in vivo. Angiogenesis (neovascularization) is a requirement for solid tumor growth and progression, and its inhibition is an important therapeutic strategy for human cancers. Our results indicate that a tumor-specific strategy such as the TNBC-targeted, anti-angiogenic therapeutic approach developed here, may be clinically useful in inhibiting TNBC progression.
Cytomegalovirus in pregnancy and the neonate

Congenital cytomegalovirus (CMV) remains a leading cause of disability in children. Understanding the pathogenesis of infection from the mother via the placenta to the neonate is crucial if we are to produce new interventions and provide supportive mechanisms to improve the outcome of congenitally infected children. In recent years, some major goals have been achieved, including the diagnosis of primary maternal CMV infection in pregnant women by using the anti-CMV IgG avidity test and the diagnosis and prognosis of foetal CMV infection by using polymerase chain reaction real-time tests to detect and quantify the virus in amniotic fluid. This review summarises recent advances in our understanding and highlights where challenges remain, especially in vaccine development and anti-viral therapy of the pregnant woman and the neonate. Currently, no therapeutic options during pregnancy are available except those undergoing clinical trials, whereas valganciclovir treatment is recommended for congenitally infected neonates with moderately to severely symptomatic disease.
The Recent Decline of the Arctic Summer Sea-Ice Cover in the Context of Internal Climate Variability

By means of a 21-year simulation of a coupled regional pan-Arctic atmosphere-ocean-ice model for the 1980s and 1990s and comparison of the model results with SSM/I satellite-derived sea-ice concentrations, the patterns of maxi- mum amplitude of interannual variability of the Arctic summer sea-ice cover are revealed. They are shown to concentrate beyond an area enclosed by an isopleth of barotropic planetary potential vorticity that marks the edge of the cyclonic rim current around the deep inner Arctic basin. It is argued that the propagation of the interannual variability signal farther into the inner Arctic basin is hindered by the dynamic isolation of upper Arctic Ocean and the high summer cloudiness usually appearing in the central Arctic. The thinning of the Arctic sea-ice cover in recent years is likely to be jointly re- sponsible for its exceptionally strong decrease in summer 2007 when sea-ice decline was favored by anomalously high atmospheric pressure over the western Arctic Ocean, which can be regarded as a typical feature for years with low sea-ice extent. In addition, unusually low cloud cover appeared in summer 2007, which led to substantial warming of the upper ocean. It is hypothesized that the coincidence of several favorable factors for low sea-ice extent is responsible for this ex- treme event. Owing to the important role of internal climate variability in the recent decline of sea ice, a temporal return to previous conditions or stabilization at the current level can not be excluded just as further decline.
Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer

Epigenetic gene inactivation plays a key role in the development of various types of cancer. Using methylated CpG island amplification coupled with representational difference analysis to identify genes inactivated by DNA methylation in gastric cancer, we identified seven DNA fragments corresponding to the 5′ CpG islands of the affected genes. One of the clones recovered was identical to the 5′ flanking region of DFNA5, a gene previously shown to be associated with deafness and induced by DNA damage. Further analysis revealed that DFNA5 is expressed in normal tissues but is downregulated in gastric cancer cell lines due to methylation of the region around its transcription start site. Treating gastric cancer cells that lacked DFNA5 expression with a methyltransferase inhibitor, 5‐aza‐2′‐deoxycytidine, restored the gene's expression. Methylation of DFNA5 was detected in 50% of primary gastric tumors, and was correlated with positivity for Epstein–Barr virus and the absence of metastasis. Moreover, introduction of exogenous DFNA5 into silenced cells suppressed colony formation. Taken together, these data suggest that the silencing of DFNA5 occurs frequently in gastric cancer and may play a key role in development and progression of the disease. (Cancer Sci 2007; 98: 88–95)
Clinical trials in allergen immunotherapy: current concepts and future needs

Allergen immunotherapy (AIT) is a safe, effective treatment for allergic rhinoconjunctivitis and allergic asthma. However, AIT's clinical effect is still contested—primarily due to heterogeneity in clinical trial designs, study populations, therapeutic formulations, and efficacy criteria. After discussing current concepts and unmet needs, an international panel of experts made several recommendations: (i) explore and validate definitions for (clinical) responders in AIT trials; (ii) use of well‐documented, standardized provocation tests prior to inclusion of subjects with relevant diseases in AIT trials; (iii) monitoring neo‐sensitizations and occurrence of new allergy in extended AIT trials, and exclusion of polyallergic participants; (iv) validation of allergen exposure chambers with regard to natural exposure; (v) in studies of seasonal allergies, focus on peak exposure but also consider organizing two parallel, geographically distinct but otherwise identical trials; (vi) discuss adaptive trial designs with the regulatory authorities; (vii) use e‐health and m‐health technologies to capture more information on individual exposure to allergens; (viii) initiate research on potential psychological, biochemical, immune, neural, and even genomic markers of the placebo response; (ix) identify trial designs and primary endpoints that will give children with allergies easier, faster access to AIT formulations; and (x) promote and apply standardized methods for reporting systemic and local adverse events. The latest technologies and trial designs may provide novel, ethical ways of reducing bias and heterogeneity in AIT clinical trials. There is scope for physicians, patient organizations, companies, and regulators to improve clinical trials in AIT and, ultimately, to provide patients with better treatments.
The PF_STAR children's speech corpus

This paper describes the corpus of recordings of children’s speech which was collected as part of the EU FP5 PF STAR project. The corpus contains more than 60 hours of speech, including read and imitated native-language speech in British English, German and Swedish, read and imitated non-nativelanguage English speech from German, Italian and Swedish children, and native-language spontaneous and emotional speech in English and German.
Anomalous photovoltaic effect in organic-inorganic hybrid perovskite solar cells

An anomalous photovoltaic effect with open-circuit voltage larger than bandgap is discovered in hybrid perovskite solar cells. Organic-inorganic hybrid perovskites (OIHPs) have been demonstrated to be highly successful photovoltaic materials yielding very-high-efficiency solar cells. We report the room temperature observation of an anomalous photovoltaic (APV) effect in lateral structure OIHP devices manifested by the device’s open-circuit voltage (VOC) that is much larger than the bandgap of OIHPs. The persistent VOC is proportional to the electrode spacing, resembling that of ferroelectric photovoltaic devices. However, the APV effect in OIHP devices is not caused by ferroelectricity. The APV effect can be explained by the formation of tunneling junctions randomly dispersed in the polycrystalline films, which allows the accumulation of photovoltage at a macroscopic level. The formation of internal tunneling junctions as a result of ion migration is visualized with Kelvin probe force microscopy scanning. This observation points out a new avenue for the formation of large and continuously tunable VOC without being limited by the materials’ bandgap.
Fault Detection Filtering for Nonhomogeneous Markovian Jump Systems via a Fuzzy Approach

This paper investigates the problem of the fault detection filter design for nonhomogeneous Markovian jump systems by a Takagi–Sugeno fuzzy approach. Attention is focused on the construction of a fault detection filter to ensure the estimation error dynamic stochastically stable, and the prescribed performance requirement can be satisfied. The designed fuzzy model-based fault detection filter can guarantee the sensitivity of the residual signal to faults and the robustness of the external disturbances. By using the cone complementarity linearization algorithm, the existence conditions for the design of fault detection filters are provided. Meanwhile, the error between the residual signal and the fault signal is made as small as possible. Finally, a practical application is given to illustrate the effectiveness of the proposed technique.
Cutting of optical materials by using femtosecond laser pulses

In the past years, ultrashort pulse lasers have been established as precise and universal tools for the microstructuring of solid materials. Since thermal and mechanical influences are minimized, the application of this technology is also suitable for the structuring of optical materials and opens new possibilities. In this paper, the influence of pulse duration, pulse energy (fluence) and polarization on the cutting quality for glass and silicon will be discussed. As a concrete application, the cutting and micromarking of dielectric coated mirrors for high power fiber lasers will be highlighted.
A zTEC H alfSquare D egree Survey ofthe SH A D ES Fields { I.M aps,C atalogues,and Source C ounts

We present the first results from the largest deep extragalactic mm-wavelength survey undertaken to date. These results are derived from maps covering over 0.7 deg2, made at λ= 1.1 mm, using the AzTEC continuum camera mounted on the James Clerk Maxwell Telescope. The maps were made in the two fields originally targeted at λ= 850 μm with the Submillimetre Common-User Bolometer Array (SCUBA) in the SCUBA Half-Degree Extragalactic Survey (SHADES) project, namely the Lockman Hole East (mapped to a depth of 0.9–1.3 mJy rms) and the Subaru/XMM–Newton Deep Field (mapped to a depth of 1.0–1.7 mJy rms). The wealth of existing and forthcoming deep multifrequency data in these two fields will allow the bright mm source population revealed by these new wide-area 1.1 mm images to be explored in detail in subsequent papers. Here, we present the maps themselves, a catalogue of 114 high-significance submillimetre galaxy detections, and a thorough statistical analysis leading to the most robust determination to date of the 1.1 mm source number counts. These new maps, covering an area nearly three times greater than the SCUBA SHADES maps, currently provide the largest sample of cosmological volumes of the high-redshift Universe in the mm or sub-mm. Through careful comparison, we find that both the Cosmic Evolution Survey (COSMOS) and the Great Observatories Origins Deep Survey (GOODS) North fields, also imaged with AzTEC, contain an excess of mm sources over the new 1.1 mm source-count baseline established here. In particular, our new AzTEC/SHADES results indicate that very luminous high-redshift dust enshrouded starbursts (S1.1mm > 3 mJy) are 25–50 per cent less common than would have been inferred from these smaller surveys, thus highlighting the potential roles of cosmic variance and clustering in such measurements. We compare number count predictions from recent models of the evolving mm/sub-mm source population to these sub-mm bright galaxy surveys, which provide important constraints for the ongoing refinement of semi-analytic and hydrodynamical models of galaxy formation, and find that all available models overpredict the number of bright submillimetre galaxies found in this survey.
Inducing Probabilistic Syllable Classes Using Multivariate Clustering

An approach to automatic detection of syllable structure is presented. We demonstrate a novel application of EM-based clustering to multivariate data, exemplified by the induction of 3- and 5-dimensional probabilistic syllable classes. The qualitative evaluation shows that the method yields phonologically meaningful syllable classes. We then propose a novel approach to grapheme-to-phoneme conversion and show that syllable structure represents valuable information for pronunciation systems.
Pre-Vaccination Frequencies of Th17 Cells Correlate with Vaccine-Induced T-Cell Responses to Survivin-Derived Peptide Epitopes

Various subsets of immune regulatory cells are suggested to influence the outcome of therapeutic antigen-specific anti-tumor vaccinations. We performed an exploratory analysis of a possible correlation of pre-vaccination Th17 cells, MDSCs, and Tregs with both vaccination-induced T-cell responses as well as clinical outcome in metastatic melanoma patients vaccinated with survivin-derived peptides. Notably, we observed dysfunctional Th1 and cytotoxic T cells, i.e. down-regulation of the CD3ζchain (p=0.001) and an impaired IFNγ-production (p=0.001) in patients compared to healthy donors, suggesting an altered activity of immune regulatory cells. Moreover, the frequencies of Th17 cells (p=0.03) and Tregs (p=0.02) were elevated as compared to healthy donors. IL-17-secreting CD4+ T cells displayed an impact on the immunological and clinical effects of vaccination: Patients characterized by high frequencies of Th17 cells at pre-vaccination were more likely to develop survivin-specific T-cell reactivity post-vaccination (p=0.03). Furthermore, the frequency of Th17 (p=0.09) and Th17/IFNγ+ (p=0.19) cells associated with patient survival after vaccination. In summary, our explorative, hypothesis-generating study demonstrated that immune regulatory cells, in particular Th17 cells, play a relevant role for generation of the vaccine-induced anti-tumor immunity in cancer patients, hence warranting further investigation to test for validity as predictive biomarkers.