Miracle-dz/UniFAR-FTUs huggingface dataset:
The DLR artificial skin step II: Scalability as a prerequisite for whole-body covers

In human skin, the ability to spatially discriminate an individual indentation from two simultaneous indentations is tailored to the need of the specific area of application on the human body. While the spatial resolution is comparatively low over wide areas of the human body, there are no insensitive spots. In addition, the measuring range is tuned to the expected loads on the respective part of the human body. Within this study these observations are utilized to solve some of the key challenges on the way towards an artificial skin as a whole-body cover for robotic systems. To enable the reliable detection of collision events which are commonly of very short duration the reaction time of the artificial skin system has to be minimized. In order to do so, the goal conflict between the required number of taxels and the required high readout frequencies has to be solved. We present the DLR approach towards scalable transduction hardware and readout electronics as a basis for the acquisition of tactile information from future whole-body covers. First experiments with prototypes of the DLR Artificial Skin demonstrate the scalability of the transduction hardware with respect to size, spatial resolution and measuring range.
The correlation of metallicity gradient with galaxy mass

ABSTRACT A number of previous studies have searched for a correlationbetween radial metal-licity gradients and early-type galaxy mass – no convincing trends have been found.Here we re-examine this issue with several key enhancements: using total metallicityfrom studies that have broken the age-metallicity degeneracy, excluding galaxies withyoung stellar ages (i.e. those that have experienced a recent central starburst) and us-ing the K-band to derive galaxy luminosities. We ﬁnd that Coma cluster galaxies havemetallicity gradients which correlate with galaxy mass. Furthermore, gradients havevalues similar to those of monolithic collapse models. The combination of dissipativeformation and energy injection from supernova provides a mechanism for the trendswith galaxy mass, however other explanations are possible. Additional high qualityobservational data is needed to further constrain the gas physics involved in galaxyformation.Key words: galaxies: abundances; galaxies: clusters: individual: Coma; galaxies:elliptical and lenticular; galaxies: formation; galaxies: structure
A model‐based approach to wildland fire reconstruction using sediment charcoal records

Lake sediment charcoal records are used in paleoecological analyses to reconstruct fire history, including the identification of past wildland fires. One challenge of applying sediment charcoal records to infer fire history is the separation of charcoal associated with local fire occurrence and charcoal originating from regional fire activity. Despite a variety of methods to identify local fires from sediment charcoal records, an integrated statistical framework for fire reconstruction is lacking. We develop a Bayesian point process model to estimate the probability of fire associated with charcoal counts from individual‐lake sediments and estimate mean fire return intervals. A multivariate extension of the model combines records from multiple lakes to reduce uncertainty in local fire identification and estimate a regional mean fire return interval. The univariate and multivariate models are applied to 13 lakes in the Yukon Flats region of Alaska. Both models resulted in similar mean fire return intervals (100–350 years) with reduced uncertainty under the multivariate model due to improved estimation of regional charcoal deposition. The point process model offers an integrated statistical framework for paleofire reconstruction and extends existing methods to infer regional fire history from multiple lake records with uncertainty following directly from posterior distributions.
Awareness, training and trust in interaction with adaptive spam filters

Even though adaptive (trainable) spam filters are a common example of systems that make (semi-)autonomous decisions on behalf of the user, trust in these filters has been underexplored. This paper reports a study of usage of spam filters in the daily workplace and user behaviour in training these filters (N=43). User observation, interview and survey techniques were applied to investigate attitudes towards two types of filters: a user-adaptive (trainable) and a rule-based filter. While many of our participants invested extensive effort in training their filters, training did not influence filter trust. Instead, the findings indicate that users' filter awareness and understanding seriously impacts attitudes and behaviour. Specific examples of difficulties related to awareness of filter activity and adaptivity are described showing concerns relevant to all adaptive and (semi-)autonomous systems that rely on explicit user feedback.
Social proximity and firm performance: the importance of family member ties in workplaces

Abstract This study empirically assesses the role of social proximity, defined as the concentration of family members (FM) in firms, on firm performance. Based on longitudinal micro-data for the period 1995–2010 connecting information on workers and their workplaces in the Swedish labour market, the effects of FM (parents, children, siblings and grandparents) on per capita productivity in 15,359 firms were analysed. The results indicate that FM positively affect firm performance. In particular, the results suggest that in specialized regions (mainly small regions) FM have a positive influence on performance and can thus compensate for relative shortage of regional agglomeration economies.
Retinoic Acid Promotes the Generation of Pancreatic Endocrine Progenitor Cells and Their Further Differentiation into β-Cells

The identification of secreted factors that can selectively stimulate the generation of insulin producing β-cells from stem and/or progenitor cells represent a significant step in the development of stem cell-based β-cell replacement therapy. By elucidating the molecular mechanisms that regulate the generation of β-cells during normal pancreatic development such putative factors may be identified. In the mouse, β-cells increase markedly in numbers from embryonic day (e) 14.5 and onwards, but the extra-cellular signal(s) that promotes the selective generation of β-cells at these stages remains to be identified. Here we show that the retinoic acid (RA) synthesizing enzyme Raldh1 is expressed in developing mouse and human pancreas at stages when β-cells are generated. We also provide evidence that RA induces the generation of Ngn3+ endocrine progenitor cells and stimulates their further differentiation into β-cells by activating a program of cell differentiation that recapitulates the normal temporal program of β-cell differentiation.
Outcome of Patients With Small Vessel Vasculitis After Renal Transplantation: National Database Analysis

Background Small vessel vasculitis commonly affects the kidney and can progress to end-stage renal disease. The goal of this study is to compare outcomes of patients who received a renal transplant as a result of small vessel vasculitis (group A) with those who received kidney transplants because of other causes (group B). Methods This is a retrospective analysis of United Network for Organ Sharing registry data for adult primary kidney transplants from January 2000 to December 2014. Group A patients (N = 2196) were compared with a group B (N = 6588); groups were case matched for age, race, sex, donor type, and year of transplant in a 1:3 ratio. Results Renal and patient survivals were better in the group A (P < 0.001). New-onset diabetes after transplant developed in 8.3% of the group A and 11.3% of group B (P < 0.001). Seventeen (0.8%) patients in group A developed recurrent disease. Of these, 7 patients had graft failure, 3 of which were due to disease recurrence. Group A patients had significantly higher risk of developing posttransplant solid organ malignancies (11.3% vs 9.3%, P = 0.006) and lymphoproliferative disorder (1.3% vs 0.8%, P = 0.026). Independent predictors of graft failure and patient mortality were recipients' morbid obesity, diabetes, age, and dialysis duration (hazard ratio of 1.7, 1.4, 1.1/10 years, and 1.1/year for graft failure, and 1.7, 1.7, 1.6/10 years and 1.1/year for patient mortality, respectively). Conclusions Renal transplantation in patients with small vessel vasculitis has favorable long-term graft and patient outcomes with a low disease recurrence rate. However, they may have a higher risk of developing posttransplant malignancies.
Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

ObjectivesGrowing evidence supports the reproductive and developmental toxicity of polycyclic aromatic hydrocarbons (PAHs) from prenatal and postnatal exposure, but the results of epidemiological studies regarding harmful effects of PAHs exposure on male reproductive system still remain limited and inconclusive. The aim of the present study was to investigate the relationship between 1-hydroxypyrene, a biomarker of polycyclic aromatic hydrocarbons exposure and semen quality.Materials and MethodsThe study population consisted of 277 men attending an infertility clinic for diagnostic purposes and having normal semen concentration of 20–300 mln/ml or slight oligozoospermia (semen concentration: 15–20 mln/ml) (WHO 1999). All the men were healthy and under 45 years of age. All participants were interviewed and provided a semen sample. The interview included questions concerning demographics, socio-economic status, medical history related to past diseases which may have an impact on semen quality, lifestyle factors and occupational information. Concentrations of 1-hydroxypyrene (1-OHP) in the urine samples were analyzed using high performance liquid chromatography (HPLC). ResultsA positive association was found between the level of 1-OHP in urine and sperm neck abnormalities as well as the percentage of static sperm cells (p = 0.001, p = 0.018, respectively). Additionally, exposure to PAHs measured by 1-OHP in urine decreased semen volume and the percentage of motile sperm cells (p = 0.014, p = 0.0001, respectively). ConclusionsPresented findings indicate that the environmental level of PAHs exposure adversely affects male semen quality. The future large-scale studies should incorporate different biomarkers to generate a more accurate and full assessment of the effects of PAHs exposure on male fertility.
Longitudinal Analysis of the Relationship Between Purposes of Internet Use and Well-being Among Older Adults

Purpose There is support for the role of Internet use in promoting well-being among older people. However, there are also contradictory findings which may be attributed to methodological issues. First, research has focused on frequency of online activity rather than how engagement in different types of online activities may influence well-being. Secondly, previous studies have used either cross-sectional designs, which cannot elucidate causality or intervention designs with uncontrolled extraneous variables. In this longitudinal observational study, we test the indirect impact of online engagement for social, informational, and instrumental purposes on older adults' well-being via reducing loneliness and supporting social engagement. Design and Method A population sample of 1,165 adults aged 60-77 (M = 68.22, SD = 4.42; 52.4% female) was surveyed over 3 waves. Using longitudinal mediation analysis with demographic controls, the indirect effects of types of Internet use on well-being through loneliness and social engagement were estimated. Results Participants engaged online for 3 purposes: social (e.g., connecting with friends/family), instrumental (e.g., banking), and informational (e.g., reading health-related information). Social use indirectly impacted well-being via decreased loneliness and increased social engagement. Informational and instrumental uses indirectly impacted well-being through engagement in a wider range of activities; however, were unrelated to loneliness. Implications Findings highlight that Internet use can support older adults' well-being; however, not every form of engagement impacts well-being the same way. These findings will inform the focus of interventions which aim to promote well-being.
Collagen architecture in pregnancy-induced protection from breast cancer

Summary The reduction in breast cancer risk attributed to early-age pregnancy is mediated in part by changes in the mammary epithelium. Here, we address the role of the mammary stroma in this protection. Utilizing tumor cells capable of transitioning from indolent to proliferative or invasive states, we demonstrate that mammary extracellular matrix (ECM) from parous rats (parous matrix) decreases tumor growth and impedes cellular phenotypes associated with tumor cell invasion compared with that observed using nulliparous matrix. Proteomic analysis identifies an increased abundance of collagen I in parous matrix, an observation extended to breast tissue of parous women. Given the pro-tumorigenic attributes of fibrillar collagen, these results were unexpected. Second-harmonic generation imaging and atomic force microscopy revealed that the abundant collagen observed in the mammary glands of parous rats is less linearized and associated with a decrease in stromal stiffness, implicating collagen organization and stiffness in parity-induced protection. Using 3D cell culture models, we demonstrate that linearized (fibrillar) collagen I induces cellular phenotypes consistent with an invasive behavior in mammary tumor cells and alters the subcellular distribution of &bgr;1 integrin. Conversely, high-density non-fibrillar collagen I induces tumor-suppressive attributes, including increases in junctional E-cadherin in tumor cells, upregulation of genes encoding components of cell–cell junctions, and downregulation of mesenchymal-specific and metalloproteinase-encoding genes. These data show that collagen organization, rather than density alone, is a key contributor to the invasive phenotype. Furthermore, our data show that parity alters the composition and organization of mammary ECM, particularly fibrillar collagen, in a manner consistent with tumor suppression.
The effects of lesions of telencephalic visual structures on visual discriminative performance in turtles (Chrysemyspicta picta)

Ascending thalamotelencephalic visuaJ pathways that terminate in specific telencephalic regions have been described in all reptiles studied. Although the anatomical data suggests that such telencephalic regions may play a role in visual processing in reptiles, few behavioral data are available. In the present study, the effects of destruction of either the core nucleus (CN) of the dorsal ventricular ridge (telencephalic terminus of the tectothal‐amofugalpathway) or the dorsal cortex (telencephalic terminus of the retino‐thalamofugal pathway) on visual discriminative performance in the turtle were examined. Following extensive bilateral destruction of the CN, turtles were severely impaired in their performance of both a simultaneous pattern discrimination and a simultaneous visual intensity discrimination. The extent of the discriminative impairment was found to be specifically correlated with the amount of CN damage. In contrast to the effects of CN lesions, lesions of the dorsal cortex had no evident effect on the performance of either a simultaneous pattern discrimination or a simultaneous visual intensity discrimination. The present results suggest that, as in birds and mammals, telencephalic visual areas play an important role in visual functions in reptiles. As in at least some birds (such as pigeons), the telencephalic terminus of the tectothalamofugal visual pathway appears to play a larger, or at least more readily measurable, role in visual discrimination than does the telencephalic terminus of the retinothalamofugal pathway.
Impact of Transformational Leadership on System Exploration in the Mandatory Organizational Context

Organizational investments in such complex information systems as customer relationship management (CRM) systems have reached a record high. Unfortunately, underutilization of these sophisticated technologies hinders organizations from realizing the promised returns on investment. This study tackles this issue from the perspective of intention to explore, which refers to individual intentions to explore the technology and seek new ways of using it. Drawing upon insights from concepts of exploration, extra-role behavior, technology acceptance, and transformational leadership, this paper proposes a research model for employees’ intention to explore in mandatory organizational contexts, with special emphasis on the effect of transformational leadership. The model was examined in a large telecom service company that uses CRM information systems. The results suggest that transformational leadership, intrinsic motivation, and extrinsic motivation (i.e. perceived usefulness) directly affect employees’ exploratory intentions. Transformational leadership also indirectly influences intention to explore through individuals’ intrinsic motivation and computer self-efficacy.
Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells

Retinal ganglion cells adapt their responses to the amplitude of fluctuations around the mean light level, or the “contrast. ” But, in mammalian retina, it is not known whether adaptation arises exclusively at the level of synaptic inputs or whether there is also adaptation in the process of ganglion cell spike generation. Here, we made intracellular recordings from guinea pig Y-type ganglion cells and quantified changes in contrast sensitivity (gain) using a linear-nonlinear analysis. This analysis allowed us to measure adaptation in the presence of nonlinearities, such as the spike threshold, and to compare adaptation in subthreshold and spiking responses. At high contrast (0.30), relative to low contrast (0.10), gain reduced to 0.82 ± 0.016 (mean ± SEM) for the subthreshold response and to 0.61 ± 0.011 for the spiking response. Thus, there was an apparent reduction in gain between the subthreshold and spiking response of 0.74 ± 0.013. Control experiments suggested that the above effects could not be explained by an artifact of the intracellular recording conditions: extracellular recordings showed a gain change of 0.58 ± 0.022. For intracellular recordings, negative current reduced the spike output but did not affect the gain change in the subthreshold response: 0.80 ± 0.051. Thus, adaptation in the subthreshold response did not require spike-dependent conductances. We conclude that the contrast-dependent gain change in the spiking response can be explained by both a synaptic mechanism, as reflected by responses in the subthreshold potential, and an intrinsic mechanism in the ganglion cell related to spike generation.
Paper-mill wastes: A putative growing medium component for ornamental plants

The research work was conducted in order to investigate the possibility of using paper-mill waste (PW) in different ratios (10%, 30%, 50% or 100% v/v) in the production of marigold (Calendula officinalis L.), petunia (Petunia x hybrita L.) and matthiola (Matthiola incana L.) plants, replacing peat in the growing medium. Different ratios of PW affected growth and nutritional related parameters. In marigold, the addition of 100% PW reduced plant height, total plant diameter, fresh weight in both leaves and flowers, as well as the total number of flowers produced per plant. In matthiola, the 100% PW reduced plant height, whereas the addition of PW even at low ratio (i.e. 10%) decreased plant diameter and fresh weight (biomass), but increased dry matter content. Petunia plants grown in 100% PW revealed lower growth (plant height and diameter) whereas adding >50% of PW into the substrate, plant fresh weight was decreased compared to the plants grown in 100% peat (control). The total number of flowers and the number of open flowers were increased (more than 2-fold) in plants grown in 30% PW compared to the control substrate, indicating flower earliness. Plants’ leaf chlorophyll content (Chl a, Chl b, total Chl) decreased as the PW ratio increased into the substrate. Total phenolics and antioxidant capacity (DPPH, FRAP) as well as plant damage index and enzymes activities varied in different species. Mineral content was fluctuated among species, while matthiola had visual phytotoxicity symptoms as they were obtained macroscopically. The present study suggests that up to 30% of PW can substitute to peat for marigold and petunia, but not for matthiola, as substrate needs further physicochemical properties improvements.
Model-Based Reproduction of Articulatory Trajectories for Consonant–Vowel Sequences

We present a novel quantitative model for the generation of articulatory trajectories based on the concept of sequential target approximation. The model was applied for the detailed reproduction of movements in repeated consonant-vowel syllables measured by electromagnetic articulography (EMA). The trajectories for the constrictor (lower lip, tongue tip, or tongue dorsum) and the jaw were reproduced. Thereby, we tested the following hypotheses about invariant properties of articulatory commands: (1) The target of the primary articulator for a consonant is invariant with respect to phonetic context, stress, and speaking rate. (2) Vowel targets are invariant with respect to speaking rate and stress. (3) The onsets of articulatory commands for the jaw and the constrictor are synchronized. Our results in terms of high-quality matches between observed and model-generated trajectories support these hypotheses. The findings of this study can be applied to the development of control models for articulatory speech synthesis.
Mucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity of gastritis

Helicobacter pylori (H. pylori) infection is associated with gastritis and marked infiltration of the gastric mucosa by several cytokines secreting inflammatory cells. Different clinical forms of the infection may reflect distinctive patterns of cytokine expression. Interleukin (IL)-17, IL-21, IL-22, and IL-23 have been reported to be involved in H. pylori-induced gastric mucosal inflammation, but the details and relationship to different patterns of inflammation and virulence factors remain unclear. The present study was launched to analyse IL-6 expression in H. pylori-infected and uninfected gastric patients and to investigate its correlation with chronic gastritis among H. pylori-infected patients. Total RNA was extracted from the gastric antrum biopsies of 48 H. pylori-infected patients and 38 H. pylori uninfected patients. Mucosal IL-21 mRNA expression level in H. pylori-infected and uninfected gastric biopsy was determined by real-time PCR. The presence of vacA (vacuolating cytotoxin A) and cagA (cytotoxin associated gene A) virulence factors were evaluated using PCR. Interleukin-21 mRNA expression was significantly high in biopsies of H. pylori-infected patients compared to H. pylori uninfected patients, and the mucosal IL-21 mRNA level was positively correlated with the grade of chronic inflammation. There was no association between virulence factors and IL-21 mRNA expression. We believe that IL-21 might be involved in the pathogenesis of H. pylori and might be an index of the severity of chronic gastritis.