Miracle-dz/UniFAR-FTUs huggingface dataset:
EEG predicts surgical outcome in lesional frontal lobe epilepsy

Background: Because of the relatively poor results of frontal lobe epilepsy (FLE) surgery, identification of prognostic factors for surgical outcome is of great importance. Methods: To identify predictive factors for FLE surgery, we analyzed the data of 61 patients (mean age at surgery 19.2) who had undergone presurgical evaluation and resective surgery in the frontal lobe. Postoperative follow-up ranged from 0.5 to 5 years (mean 1.78). Fifty-nine patients had MRI-detectable lesions. Histopathologic examination showed dysplasia (57.4%), tumor (16.4%), or other lesions (26.2%). Thirty postoperatively seizure-free patients were compared with 31 non–seizure-free patients with respect to clinical history, seizure semiology, EEG and neuroimaging data, resected area, and postoperative data including histopathology. Results: Three preoperative and two postoperative variables were related to poor outcome: generalized epileptiform discharges, generalized slowing, use of intracranial electrodes, incomplete resection detected by MRI, and postoperative epileptiform discharges. The only preoperative factor associated with seizure-free outcome was the absence of generalized EEG signs. Multivariate analysis showed that only the absence of generalized EEG signs predicts the outcome independently. Moreover, the occurrence of a somatosensory aura, secondarily generalized seizures, and negative MRI was identified as additional independent risk factors for poor surgical results. Conclusions: The absence of generalized EEG signs is the most predictive variable for a seizure-free outcome in FLE surgery. Furthermore, nonlesional MRI, somatosensory aura, and secondarily generalized seizures are risk factors for poor surgical results.
Solution structural studies of the Saccharomyces cerevisiae TATA binding protein (TBP).

The intrinsic fluorescence of the six tyrosines located within the C-terminal domain of the Saccharomyces cerevisiae TATA binding protein (TBP) and the single tryptophan located in the N-terminal domain has been used to separately probe the structural changes associated with each domain upon DNA binding or oligomerization of the protein. The unusually short-wavelength maximum of TBP fluorescence is shown to reflect the unusually high quantum yield of the tyrosine residues in TBP and not to result from unusual tryptophan fluorescence. The anisotropy of the C-terminal tyrosines is very high in monomeric, octameric, and DNA-complexed TBP and comparable to that observed in much larger proteins. The tyrosines have low accessibility to an external fluorescence quencher. The anisotropy of the single tryptophan located within the N-terminal domain of TBP is much lower than that of the tyrosines and is accessible to an external fluorescence quencher. Tyrosine, but not tryptophan, fluorescence is quenched upon TBP-DNA complex formation. Only the tryptophan fluorescence is shifted to longer wavelengths in the protein-DNA complex. In addition, the accessibility of the tryptophan residue to the external quencher and the internal motion of the tryptophan residue increase upon DNA binding by TBP. These results show the following: (i) The structure of the C-terminal domain structure is unchanged upon TBP oligomerization, in contrast to the N-terminal domain [Daugherty, M. A. , Brenowitz, M. , and Fried, M. G. (2000) Biochemistry 39, 4869-4880]. (ii) The environment of the tyrosine residues within the C-terminal domain of TBP is structurally rigid and unaffected by oligomerization or DNA binding. (iii) The C-terminal domain of TBP is uniformly in close proximity to bound DNA. (iv) While the N-terminal domain unfolds upon DNA binding by TBP, its increased correlation time shows that the overall structure of the protein is more rigid when complexed to DNA. A model that reconciles these results is proposed.
Proactivity during organizational entry: The role of desire for control.

This study described the various ways that newcomers proactively attempt to gain feelings of personal control during organizational entry and examined their longitudinal effects on self-reported performance and satisfaction in a sample of organizational newcomers. The results suggest that individuals engage in proactive activities such as information and feedback seeking, relationship building, job-change negotiating, and positive framing during entry and that individual differences in desired control were related to 6 proactive entry tactics. However, only some of these tactics were related to self-reported performance and job satisfaction. The socialization literature describes the ways in which organizations mold and shape individual behavior (Van Maanen & Schein, 1979). The literature has focused on stages of socialization and on situational factors that influence individuals during the entry period (Reichers, 1987). More recently, researchers have begun to examine the role that individual dispositions might play in the en
IDEAS A ND PERSPECTIVES Pollinators as mediators of top-down effects on plants

This paper explores the idea that predators may disrupt plant–pollinator relationships and consequently inhibit reproduction in flowering plants. Amidst growing evidence that predators influence plant–pollinator interactions, I suggest that such pollinator-mediated indirect effects may be a common feature of terrestrial communities, with implications for research into top-down effects and pollination ecology. Experimental evidence of such an effect from a riparian system in northern California is provided, where crab spiders decreased seed production in inflorescences of the invasive plant Leucanthemum vulgare by reducing the frequency and duration of floral visits by pollinating insects.
Active Long Term Memory Networks

Continual Learning in artificial neural networks suffers from interference and forgetting when different tasks are learned sequentially. This paper introduces the Active Long Term Memory Networks (A-LTM), a model of sequential multi-task deep learning that is able to maintain previously learned association between sensory input and behavioral output while acquiring knew knowledge. A-LTM exploits the non-convex nature of deep neural networks and actively maintains knowledge of previously learned, inactive tasks using a distillation loss. Distortions of the learned input-output map are penalized but hidden layers are free to transverse towards new local optima that are more favorable for the multi-task objective. We re-frame the McClelland's seminal Hippocampal theory with respect to Catastrophic Inference (CI) behavior exhibited by modern deep architectures trained with back-propagation and inhomogeneous sampling of latent factors across epochs. We present empirical results of non-trivial CI during continual learning in Deep Linear Networks trained on the same task, in Convolutional Neural Networks when the task shifts from predicting semantic to graphical factors and during domain adaptation from simple to complex environments. We present results of the A-LTM model's ability to maintain viewpoint recognition learned in the highly controlled iLab-20M dataset with 10 object categories and 88 camera viewpoints, while adapting to the unstructured domain of Imagenet with 1,000 object categories.
Protective effect of exogenous matrix metalloproteinase-9 on chronic renal failure

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have pivotal functions in extracellular matrix turnover and are involved in chronic kidney diseases. However, the exact functions of MMPs in chronic renal failure (CRF) have yet to be demonstrated. The aim of the present study was to examine the effects of MMP-9 on CRF. An adenine-induced model of CRF was generated in rabbits. Following the injection of MMP-9 into the renal arteries of the rabbits, significant improvements in renal morphology and serum levels of creatinine and urea nitrogen were observed. Furthermore, MMP-9 administration was shown to decrease the serum TIMP-1 concentration and upregulate renal MMP-9 expression. These results demonstrate a directly protective role for MMP-9 in CRF.
The Process of Transition to Hemodialysis: A Grounded Theory Research

Background: Transition is a passage or movement from one state, condition, or place to another. Patients with chronic disorders such as end-stage renal disease experience transitions. This study aims to explore the process of transition to hemodialysis. Materials and Methods: This is a qualitative grounded theory of a doctoral dissertation. Twenty-four participants (19 patients on hemodialysis, 2 family members, 2 nurses, and a physician) were selected through purposive and theoretical sampling until data saturation. Data collection was conducted through semi-structured interviews, as well as field notes and memos. Data analysis was done concurrently with data collection in three levels of open, axial, and selective coding according to the Strauss and Corbin (1998) method. Core variable was appeared at the end of selecting coding stage. Results: Confronting unexpected situation of hemodialysis, challenge of accepting hemodialysis, comprehensive and pervasive changes, efforts made to self-management, and integration of hemodialysis with everyday life were considered to be the main themes of the process of transition to hemodialysis. Conclusions: The results would increase evidence-based knowledge regarding the process of transition to hemodialysis. Through identification of this process, effective factors such as determining strategies for management would lead to facilitate more specialized care of people undergoing hemodialysis, appropriate nursing interventions and more effective training programs to prepare patients and their families during the process of transition to hemodialysis. These results can be used for conducting and preparing other qualitative and quantitative studies.
Contrasting perspectives on work: an exploratory qualitative study based on the concept of adaptation.

This article was acceptedfor publication March 10, 1998. Objectives. Objectives ofthis study were (a) to compare contrasting work experiences offive persons as alternative ways individuaLs select and use occupationaL opportunities availabLe in their environments, and (b) to examine the adaptive significance ofwork in their Lives. Method. Five students in a graduate course on work and playas occupations each devewped a work narrative fOr an aduLt oftheir choice that incLuded how that person came to choose particular kinds ofwork, described the person's current work experience, and examined the adaptive significance ofwork in the person's Life. Data were gathered through observations in the persons' work settings and through open-ended interviews. Comparative analysis of the five work narratives was completed by students and facuLty members as a group. Resul ts. WOrk narratives ofafast-fOod restaurant manager, a Life-flight nurse, a tennis teaching pro, a financiaL analyst, and a manufacturer's representative fOr oilfield equipment ilLustrate contrasting perspectives on work as "escapingfrom secLusion," "establishing Life work," "enacting a family tradition, " "getting stuck, "and "rebuilding a Life. " The participants who modified or combined occupationaL opportunities in creative ways generaLly fOund their work more rewarding than those who accepted availabLe work opportunities as unaLterable "givens. " Conclusions. The adaptive significance ofwork fOr these persons had both short-term benefits, incLuding intrinsic enjoyment ofits activities and extrinsic benefits, such as sociaL recognition and income, and wng-term benefits of contributions to identity and contributions to purposes Larger than oneself
Nitrogen‐fixing chemo‐organotrophic bacteria isolated from cyanobacteria‐deprived lichens and their ability to solubilize phosphate and to release amino acids and phytohormones

Aims: Cyanobacteria‐deprived lichens of the species Canoparmelia caroliniana, Canoparmelia crozalsiana, Canoparmelia texana, Parmotrema sancti‐angeli and Parmotrema tinctorum were screened for the presence of chemo‐organotrophic nitrogen‐fixing bacteria.
Geometry of extended null supersymmetry in M theory

For supersymmetric spacetimes in 11 dimensions admitting a null Killing spinor, a set of explicit necessary and sufficient conditions for the existence of any number of arbitrary additional Killing spinors is derived. The necessary and sufficient conditions are comprised of algebraic relationships, linear in the spinorial components, between the spinorial components and their first derivatives, and the components of the spin connection and four-form. The integrability conditions for the Killing spinor equation are also analyzed in detail, to determine which components of the field equations are implied by arbitrary additional supersymmetries and the four-form Bianchi identity. This provides a complete formalism for the systematic and exhaustive investigation of all spacetimes with extended null supersymmetry in 11 dimensions. The formalism is employed to show that the general bosonic solution of 11 dimensional supergravity admitting a G{sub 2} structure defined by four Killing spinors is either locally the direct product of R{sup 1,3} with a seven-manifold of G{sub 2} holonomy, or locally the Freund-Rubin direct product of AdS{sub 4} with a seven-manifold of weak G{sub 2} holonomy. In addition, all supersymmetric spacetimes admitting a (G{sub 2}xR{sup 7})xR{sup 2} structure are classified.
Problematic Internet Users' Discounting Behaviors Reflect an Inability to Delay Gratification, Not Risk Taking

The relationship between impulse control disorder (ICD) behaviors and problematic Internet use (PIU) has been established in the literature. Our aim was to further investigate whether the ICDs of individuals suffering from PIU primarily involve an inability to delay gratification or a tendency to take risks. Using delay and probability discounting tasks, we compared the subjective value of discounting between PIU individuals and controls in conditions of gaining or losing different monetary amounts. The results of the present study revealed a significant positive relationship between PIU and impulsivity scores. PIU individuals discounted delayed amounts more steeply than controls, regardless of the reward sign and monetary amount. Conversely, there were no significant group differences in the probability discounting task. These findings suggest that PIU individuals may be more impulsive than controls when impulsivity is framed as insensitivity to delayed outcomes rather than as a tendency to take risks, which is inconsistent with the view of impulsivity as a general trait.
Local Optima Networks of the Quadratic Assignment Problem

Using a recently proposed model for combinatorial landscapes, Local Optima Networks (LON), we conduct a thorough analysis of two types of instances of the Quadratic Assignment Problem (QAP). This network model is a reduction of the landscape in which the nodes correspond to the local optima, and the edges account for the notion of adjacency between their basins of attraction. The model was inspired by the notion of ‘inherent network’ of potential energy surfaces proposed in physical-chemistry. The local optima networks extracted from the so called uniform and real-like QAP instances, show features clearly distinguishing these two types of instances. Apart from a clear confirmation that the search difficulty increases with the problem dimension, the analysis provides new confirming evidence explaining why the real-like instances are easier to solve exactly using heuristic search, while the uniform instances are easier to solve approximately. Although the local optima network model is still under development, we argue that it provides a novel view of combinatorial landscapes, opening up the possibilities for new analytical tools and understanding of problem difficulty in combinatorial optimization.
Approaching a realistic force balance in geodynamo simulations

Significance Flow in Earth’s liquid core is expected to be primarily governed by the Coriolis force due to Earth’s rotation, the buoyancy force driving the convection, and the Lorentz force due to the geomagnetic field. A relevant geodynamo model has to be in such a force balance. Contemporaneous simulations invoke high viscosities to suppress flow turbulence to keep the computational costs manageable. The unrealistically large viscosity in these simulations is a major concern. Here we show that the state-of-the-art simulations with a viscosity that is lower than in most simulations, but still much larger than in Earth’s core, can approach a realistic force balance. Our simulations produce many properties that have been theoretically predicted in the past. Earth sustains its magnetic field by a dynamo process driven by convection in the liquid outer core. Geodynamo simulations have been successful in reproducing many observed properties of the geomagnetic field. However, although theoretical considerations suggest that flow in the core is governed by a balance between Lorentz force, rotational force, and buoyancy (called MAC balance for Magnetic, Archimedean, Coriolis) with only minute roles for viscous and inertial forces, dynamo simulations must use viscosity values that are many orders of magnitude larger than in the core, due to computational constraints. In typical geodynamo models, viscous and inertial forces are not much smaller than the Coriolis force, and the Lorentz force plays a subdominant role; this has led to conclusions that these simulations are viscously controlled and do not represent the physics of the geodynamo. Here we show, by a direct analysis of the relevant forces, that a MAC balance can be achieved when the viscosity is reduced to values close to the current practical limit. Lorentz force, buoyancy, and the uncompensated (by pressure) part of the Coriolis force are of very similar strength, whereas viscous and inertial forces are smaller by a factor of at least 20 in the bulk of the fluid volume. Compared with nonmagnetic convection at otherwise identical parameters, the dynamo flow is of larger scale and is less invariant parallel to the rotation axis (less geostrophic), and convection transports twice as much heat, all of which is expected when the Lorentz force strongly influences the convection properties.
Analog VLSI Circuit Implementation of an Adaptive Neuromorphic Olfaction Chip

In this paper, we present the analog circuit design and implementation of the components of an adaptive neuromorphic olfaction chip. A chemical sensor array employing carbon black composite sensing materials with integrated signal processing circuitry forms the front end of the chip. The sensor signal processing circuitry includes a dc offset cancellation circuit to ameliorate loss of measurement range associated with chemical sensors. Drawing inspiration from biological olfactory systems, the analog circuits used to process signals from the on-chip odor sensors make use of temporal "spiking" signals to act as carriers of odor information. An on-chip spike time dependent learning circuit is integrated to dynamically adapt weights for odor detection and classification. All the component subsystems implemented on chip have been successfully tested in silicon
The CHLI1 Subunit of Arabidopsis thaliana Magnesium Chelatase Is a Target Protein of the Chloroplast Thioredoxin*

Insertion of magnesium into protoporphyrin IX by magnesium chelatase is a key step in the chlorophyll biosynthetic pathway, which takes place in plant chloroplasts. ATP hydrolysis by the CHLI subunit of magnesium chelatase is an essential component of this reaction, and the activity of this enzyme is a primary determinant of the rate of magnesium insertion into the chlorophyll molecule (tetrapyrrole ring). Higher plant CHLI contains highly conserved cysteine residues and was recently identified as a candidate protein in a proteomic screen of thioredoxin target proteins (Balmer, Y., Koller, A., del Val, G., Manieri, W., Schurmann, P., and Buchanan, B. B. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 370–375). To study the thioredoxin-dependent regulation of magnesium chelatase, we first investigated the effect of thioredoxin on the ATPase activity of CHLI1, a major isoform of CHLI in Arabidopsis thaliana. The ATPase activity of recombinant CHLI1 was found to be fully inactivated by oxidation and easily recovered by thioredoxin-assisted reduction, suggesting that CHLI1 is a target protein of thioredoxin. Moreover, we identified one crucial disulfide bond located in the C-terminal helical domain of CHLI1 protein, which may regulate the binding of the nucleotide to the N-terminal catalytic domain. The redox state of CHLI was also found to alter in a light-dependent manner in vivo. Moreover, we successfully observed stimulation of the magnesium chelatase activity in isolated chloroplasts by reduction. Our findings strongly suggest that chlorophyll biosynthesis is subject to chloroplast biogenesis regulation networks to coordinate them with the photosynthetic pathways in chloroplasts.
Passive versus active engulfment: verdict from trajectory simulations of lunge-feeding fin whales Balaenoptera physalus

Lunge-feeding in rorqual whales represents the largest biomechanical event on Earth and one of the most extreme feeding methods among aquatic vertebrates. By accelerating to high speeds and by opening their mouth to large gape angles, these whales generate the water pressure required to expand their mouth around a large volume of prey-laden water. Such large influx is facilitated by highly extensible ventral groove blubber (VGB) associated with the walls of the throat (buccal cavity). Based on the mechanical properties of this tissue, previous studies have assumed lunge-feeding to be an entirely passive process, where the flow-induced pressure driving the expansion of the VGB is met with little resistance. Such compliant engulfment would be facilitated by the compliant properties of the VGB that have been measured on dead specimens. However, adjoining the ventral blubber are several layers of well-developed muscle embedded with mechanoreceptors, thereby suggesting a capability to gauge the magnitude of engulfed water and use eccentric muscle action to control the flux of water into the mouth. An unsteady hydrodynamic model of fin whale lunge-feeding is presented here to test whether engulfment is exclusively passive and compliant or involves muscle action. The model is based on the explicit simulation of the engulfed water as it interacts with the buccal cavity walls of the whale, under different heuristically motivated cavity forces. Our results, together with their comparison with velocity data collected in the field, suggest that adult rorquals actively push engulfed water forward from the very onset of mouth opening in order to successfully complete a lunge. Interestingly, such an action involves a reflux of the engulfed mass rather than the oft-assumed rebound, which would occur mainly at the very end of a lunge sequence dominated by compliant engulfment. Given the great mass of the engulfed water, reflux creation adds a significant source of hydrodynamic drag to the lunge process, but with the benefit of helping to circumvent the problem of removing prey from baleen by enhancing the efficiency of cross-flow filtration after mouth closing. Reflux management for a successful lunge will therefore demand well-coordinated muscular actions of the tail, mouth and ventral cavity.