Miracle-dz/UniFAR-FTUs huggingface dataset:
The LIM Protein AJUBA Recruits Protein Arginine Methyltransferase 5 To Mediate SNAIL-Dependent Transcriptional Repression

ABSTRACT The SNAIL transcription factor contains C-terminal tandem zinc finger motifs and an N-terminal SNAG repression domain. The members of the SNAIL family have recently emerged as major contributors to the processes of development and metastasis via the regulation of epithelial-mesenchymal transition events during embryonic development and tumor progression. However, the mechanisms by which SNAIL represses gene expression are largely undefined. Previously we demonstrated that the AJUBA family of LIM proteins function as corepressors for SNAIL and, as such, may serve as a platform for the assembly of chromatin-modifying factors. Here, we describe the identification of the protein arginine methyltransferase 5 (PRMT5) as an effector recruited to SNAIL through an interaction with AJUBA that functions to repress the SNAIL target gene, E-cadherin. PRMT5 binds to the non-LIM region of AJUBA and is translocated into the nucleus in a SNAIL- and AJUBA-dependent manner. The depletion of PRMT5 in p19 cells stimulates E-cadherin expression, and the SNAIL, AJUBA, and PRMT5 ternary complex can be found at the proximal promoter region of the E-cadherin gene, concomitant with increased arginine methylation of histones at the locus. Together, these data suggest that PRMT5 is an effector of SNAIL-dependent gene repression.
A Daily Determination of BZ Using the Russell‐McPherron Effect to Forecast Geomagnetic Activity

Since the middle of the last decade, UCSD has incorporated magnetic field data in its Institute for Space‐Earth Environmental Research interplanetary scintillation tomographic analysis. These data are extrapolated upward from the solar surface using the Current Sheet Source Surface model (Zhao & Hoeksema, 1995, https://doi.org/10.1029/94JA02266) to provide predictions of the interplanetary field in RTN coordinates. Over the years this technique has become ever more sophisticated, and allows different types of magnetogram data (SOLIS, Global Oscillation Network Group, etc.,) to be incorporated in the field extrapolations. At Earth, these fields can be displayed in a variety of ways, including Geocentric Solar Magnetospheric (GSM) Bx, By, and Bz coordinates. Displayed daily, the Current Sheet Source Surface model‐derived GSM Bz shows a significant positive correlation with the low‐resolution (few day variation) in situ measurements of the Bz field. The nano‐Tesla variations of Bz maximize in spring and fall as Russell and McPherron (1973, https://doi.org/10.1029/JA078i001p00092) have shown. More significantly, we find that the daily variations are correlated with geomagnetic Kp and Dst index variations, and that a decrease from positive to negative Bz has a high correlation with minor‐to‐moderate geomagnetic storm activity, as defined by NOAA Space Weather Prediction Center planetary Kp values. Here we provide an 11‐year study of the predicted Bz field, from the extrapolation of the Global Oscillation Network Group‐magnetograms. We provide a skill‐score analysis of the technique's geomagnetic storm prediction capability, which allows forecasts of moderate enhanced geomagnetic storm activity. UCSD and the Korean Space Weather Center currently operate a website that predicts this low‐resolution GSM Bz field component variation several days in advance.
Large-Scale Bayesian Logistic Regression for Text Categorization

Logistic regression analysis of high-dimensional data, such as natural language text, poses computational and statistical challenges. Maximum likelihood estimation often fails in these applications. We present a simple Bayesian logistic regression approach that uses a Laplace prior to avoid overfitting and produces sparse predictive models for text data. We apply this approach to a range of document classification problems and show that it produces compact predictive models at least as effective as those produced by support vector machine classifiers or ridge logistic regression combined with feature selection. We describe our model fitting algorithm, our open source implementations (BBR and BMR), and experimental results.
Symbolic Class Struggles and the Intersection of Socioeconomic, Cultural and Moral Categorisations

The symbolic categorisation of social groups has become prominent in studies of social class. This article addresses a tension in this research regarding the relationship between different symbolic categories. We argue that the potential of moral categorisations to change or oppose the order of socioeconomic or cultural categorisations depends on whether moral categories are subordinate in a hierarchy or co-exist in a heterarchy of multiple symbolic categories. We explore the relationship between cultural, socioeconomic and moral categorisations by combining focus group and survey data among Danish citizens in a mixed-methods research design. Our study shows that moral categorisations are opposed but also subordinated to socioeconomic categorisations. Such categorisations therefore serve to legitimise rather than transform class inequality. This has important implications for understanding class relations in modern societies as well as for the study of symbolic categorisations, and it highlights the importance of studying the interrelationship between multiple symbolic categories.
Simultaneous Velocity and Position Estimation via Distance-Only Measurements With Application to Multi-Agent System Control

This paper proposes a strategy to estimate the velocity and position of neighbor agents using distance measurements only. Since with agents executing arbitrary motions, instantaneous distance-only measurements cannot provide enough information for our objectives, we postulate that agents engage in a combination of circular motion and linear motion. The proposed estimator can be used to develop control algorithms where only distance measurements are available to each agent. As an example, we show how this estimation method can be used to control the formation shape and secure velocity consensus of the agents in a multi agent system.
Skolan och den "goda" utbildningen : för ett konkurrenskraftigt Europa

This thesis takes its departure in the recent criticism directed to the Swedish school system and its schools, teachers and pupils, but especially the epidemic of policies produced in order to develop and improve Swedish schools, in particular after the change of government in 2006. The general aim of this thesis is to study how teachers and pupils are represented, and thus constructed, regulated and positioned in a number of current key policy texts. The study also involves a discussion of the construction and regulation practices regarding the school, and its role in society. The main context for the study is policy texts and policy practices related to teacher education. Four studies form the cornerstone of the thesis. Through these policy texts different institutional practices are analyzed. These range from European union policy to examination data from a local teacher education institution in Sweden. A main source of inspiration to the theoretical framework of the study has been provided by the work of Michel Foucault. However, in addition to Foucault's constructionist and poststructural basis, theoretical and methodological approaches drawn from Norman Fairclough's critical discourse analysis, Mark Olssen's social-materialist analysis of policy and Stephen J Ball's policy sociology are also included. The first study examines the constructions and governing technologies in four policy texts within the European Union working programme 'Education 2010'. The second study takes a historical perspective in the construction of teachers and pupils, based on teacher education policy text since 1948, and how the ideal teacher, pupil and school are constructed and positioned genealogically. The third study explores the discursive notions of teacher professionalism and how the regulation of teachers operates through this and other discursive practices by the Swedish government and the Teacher union (Lararforbundet) during two different time periods, 1995-2000 and 2007-2008. The final study examines student teachers' examination assignments, as a local policy practice, and how the student teachers position the ideal pupil and themselves as ideal teachers. It examines how different policy discourses operate in relation to positioning practices. The thesis shows that current neoliberal discourse order in educational policy today is partly challenged by neoconservative rationalities. Secondly, the thesis shows how each teacher and pupil is governed through several discourses, governing technologies and governing techniques, and how these three entities function relationally in the governing of the subject. In common for discourses, governing technologies and techniques are that they are often very 'seductively packaged', which implies that it is almost impossible to resist and oppose them. Finally I claim that the current discourse order, and its discourses, and governing technologies and techniques imply structural inequalities for teachers, but especially between different pupil groups
Measurements of droplet deformation in simple shear flow with zero interfacial tension

The deformation of Newtonian droplets with zero interfacial tension in a Newtonian matrix is studied in simple shear flow for viscosity ratios ranging from 0.095 to 10.29. The experiments use a counter-rotating Couette apparatus driven by independent servo motors, with a control scheme that keeps the droplet centered under a video camera. Droplet deformation is measured by analyzing the video images, using the method of moments. Both the matrix and the droplet are silicone oils, and the droplet contains a fluorescent dye. Low-viscosity droplets stretch monotonically, while higher viscosity droplets may stretch, wobble, or tumble. The theory of Wetzel and Tucker (2001) for ellipsoidal droplets with zero interfacial tension is compared to the data, by adjusting those portions of the initial shape and orientation that are not observable in the experiment. The agreement is excellent in all cases, requiring only that the initial droplet shape be close to an ellipsoid.
Fitness costs of herbicide resistance across natural populations of the common morning glory, Ipomoea purpurea

Although fitness costs associated with plant defensive traits are widely expected, they are not universally detected, calling into question their generality. Here we examine the potential for life history trade-offs associated with herbicide resistance by examining seed germination, root growth, and above-ground growth across 43 naturally occurring populations of Ipomoea purpurea that vary in their resistance to RoundUp®, the most commonly used herbicide worldwide. We find evidence for life history trade-offs associated with all three traits; highly resistant populations had lower germination rates, shorter roots and smaller above-ground size. A visual exploration of the data indicated that the type of trade-off may differ among populations. Our results demonstrate that costs of adaptation may be present at stages other than simply the production of progeny in this agricultural weed. Additionally, the cumulative effect of costs at multiple life cycle stages can result in severe consequences to fitness when adapting to novel environments.
Topology Based Performance Analysis of IEEE 802.15.4 for Wireless Sensor Networks

Wireless Local Area Networking standard (Wi-Fi) and the WPAN standard (Bluetooth and Zigbee) products utilize the same unlicensed 2.4 GHz ISM band. Co-existence between such wireless technologies within the same frequency spectrum is crucial to ensure that each wireless technology maintains and provides its desired performance requirements. Wireless Personal Area Networks are formed using tiny sensor devices which have several resource constraints. A new standard IEEE 802.15. 4 was uniquely designed to suit personal wireless networks requirement consuming low power, provides low data rate and low cost. In this paper, an effort is made to analyze the performance of IEEE 802.15. 4 in heterogeneous simulation environment. The simulation in NS2 is carried out for three types network topology with varying network density. To cover all the scenarios, we have considered scatternet, piconet and peer to peer topologies. Both beacon and non beacon enabled experiments are carried out on different traffic type. It is already known fact that IEEE 802.15. 4 outperforms than IEEE 802.11 in terms of routing overhead and also power consumption. In this paper, we also discuss the reasons that could degrade the overall network performance as well as association efficiency.
An effective lower bound for group complexity of finite semigroups and automata

The question of computing the group complexity of finite semigroups and automata was first posed in K. Krohn and J. Rhodes, Complexity of finite semigroups, Annals of Mathematics (2) 88 (1968), 128–160, motivated by the Prime Decomposition Theorem of K. Krohn and J. Rhodes, Algebraic theory of machines, I: Prime decomposition theorem for finite semigroups and machines, Transactions of the American Mathematical Society 116 (1965), 450–464. Here we provide an effective lower bound for group complexity.
Work Outcomes and Job Design for Contract Versus Permanent Information Systems Professionals on Software Development Teams

Organizations have significantly increased their use of contracting in information systems (IS), hiring contractors to work with permanent professionals. Based on theories of social exchange and social comparison, we hypothesize differences in work attitudes, behaviors, and performance across the two groups, and evaluate our hypotheses with a sequential mixed-methods design. Our first study surveys contract and permanent professionals on software development teams in a large transportation company. Our second study involves in-depth interviews with contract and permanent IS professionals in three organizations. We find support for many of our hypotheses but also some surprising results. Contrary to our predictions, contractors perceive a more favorable work environment than permanent professionals but exhibit lower in-role and extra-role behaviors than their permanent counterparts. Supervisors perceive their contract subordinates as lower-performing and less loyal, obedient, and trustworthy. In-depth interviews help to explain these findings. Job design emerges as an important factor influencing contractors' work attitudes, behaviors, and performance. Supervisors restrict the scope of contractors' jobs, limiting their job behaviors and performance. To compensate, permanent professionals are assigned considerably enlarged job scopes, leading to their lower perceptions of the work environment. We propose a theoretical model that embraces job design in explaining differences in work outcomes for contract versus permanent professionals on software development teams. The results from our study imply that organizations should carefully design and balance the jobs of their contractors and permanent employees to improve attitudes, behaviors, and workplace performance.
Reasons for intending to have no children in Tehran, Iran

Background and Objective: Over the past two decades the total fertility rate has remained the below-replacement level (two children per woman), which can lead to aging population and hence shortage of labor forces required for the development of the country. This research aimed to study reasons behind the intention to have no children. Materials and Methods: This descriptive study uses data from the 2012 Tehran Survey of Fertility Intentions (n= 2267), conducted among married men and women under aged 36 living in 22 districts of the city of Tehran. The samples were selected by a two stage cluster random sampling method, and a structured questionnaire was used to collect data by interviewing respondents face-to-face at the door of their residence. Using SPSS version 24 and descriptive statistics, reasons for not wanting children were examined according to respondents’ socio-economic characteristics. Results: Overall, 40% (902) of respondents reported that they intend not to have any children in the future. Number of living children was negatively related to the intention to have children. About 9% (67) of childless respondents reported that they intend to remain childless forever, and 34% (302) of respondents with one child and 81% (443) of those having two children stated that they intend to stop childbearing. “Not being able to afford the cost of raising children” (27%), “having the desired number of children” (25%), “being worry about the future of their children” (15%) as the most important reasons for not wanting any (more) children. The other reason for intending not to have children was “conflict of childbearing with own personal life, plans and interests” (16%), which was reported largely by men, and those with higher levels of education and income, and those with one or no child. Respondents also reported “spouse’s opposition” 6%) and “problems in spousal relationships” (2%) as the other reasons for wanting no more children. Conclusion: The study showed that beyond of economic reasons, uncertainty about children’s future and childbearing-personal life conflict are two other important cultural and social reasons for low fertility intention, which are required to be considered by policy makers developing or tailoring the country’s population policies. DOI: http://doi.org/10.22037/ch.v6i2. 22583
Risk and Protective Factors Associated with Academic Achievement among Ghanaian Youth.

Young people in Ghana who grow up in poverty and to families with little or no education endure limited early learning opportunities, underfunded educational syste ms, and more health and mental health problems compared to their peers from more privileged backgrounds. A significant body of literature addressing the rela tionship among risk, protection, resilience and academic achievement is based on youth populations in North America and Western Europe. Relatively little is known about the applicability of ecological and risk and resilience frameworks in non-Weste rn countries. Consequently, educational outcomes of young people in Ghana are often characterized b y similarities in low achievement, lack of teachers, school supplies, and dilapidat ed school buildings. Such characterizations mask internal and social resources of individuals i n Ghana. In an attempt to understand the processes of students’ academic achieveme nt in Ghana, this study examined the relationship among risk, protection, and academic achievement of 276 first-year college students in Ghana. Using a mixed methods desig n, the study applied ecological theory and the risk and resilience framework to m easure personal, family, and environmental conditions that enhanced or inhibited achievement. Bivariate analyses revealed gender and regional differences in measures o f protection and risk relative to school achievement. These included parental and individual drug abuse, neighborhood safety, school mentor, neighborhood cohesion, collective efficacy, and parental educational values. Hierarchical multiple regression analyse s rev aled iii significant relationships between students’ grades and sense of optimism, region of residence, presence of a school mentor, parental social support, and neighborhood safety. Results suggest that there are important gender and regional differences in Ghanaian youths’ access and exposure to systems of support and risks. Implications of these findings, limitations of the study design, and directions for future research ar e discussed.
Images of Setting in the Primary Classroom

Setting in Scottish primary schools is a relatively recent phenomenon and should be regarded as experimental rather than as an established alternative model of organising groups of pupils. Setting is defined here as arranging students for a given curriculum area in separate classes with different teachers, based on students’ attainment levels in that particular area. Setting has been advocated in Scottish secondary schools and also, in some contexts, in primary schools (SOEID, 1996): it is attractive to some Education Authorities and Headteachers; although others are more cautious or even sceptical about the efficacy of the method. The research reported here was part of a larger two and a half year study of 16 primary schools which was completed in 1999. In the four case-study schools which this paper highlights, setting was operating for Mathematics. This paper outlines the various research methods used and illustrates some of the topical issues (both positive and negative) for students and their teachers associated with setting in the context of these four primary schools. A question is posed about whether the differentiation disaffection of many students found in previous studies of setting in schools in England is exactly replicated in these four Scottish schools.
The MDR1/ABCB1 Gene, a High-Impact Risk Factor for Cardiac Transplant Rejection

Background. Variations in the expression and activity levels of the multidrug-resistance MDR1/ABCB1 encoded P- glycoprotein (P-gp) have an impact on the therapeutic efficacy of many drugs. C3435T and G2677 polymorphisms of the MDR1/ABCB1 gene correlate with cellular expression levels of P-gp, a membrane-bound efflux pump which removes a multitude of drugs, including chemotherapy drugs and immunosuppressants, from cells. We aimed to investigate whether the phenomenon of drug resistance, mediated by the MDR1/ABCB1 gene and seen in tumor cells to chemotherapeutic agents, is important in the field of transplantation, predisposing some patients to resistance to immunosuppressants. Methods. G2677 and C3435T polymorphisms of the ABCB1 gene were determined by PCR in 170 heart transplant recipients. We examined the relationship between MDR1/ABCB1 polymorphisms and endomyocardial biopsy-proven rejection (EBPR) determined by biopsy performed at set intervals according to a standard protocol. Results. A significant relationship was found between a patient's C3435T genotype and freedom from first grade ≥3A rejection episode. 3435-CC recipients were 1.8 times (1.05–3.09; P=0.03) more likely to undergo a ≥3A rejection episode in the first 12 months. Haplotypes derived from the G2677 and C3435T polymorphisms (GG/CC, GT/CT and TT/TT) amplified this phenomenon further (log rank, P=0.03; HR 2.18; 1.21–4.26; P=0.02). Conclusions. ABCB1 polymorphisms correlate with freedom from grade ≥3A EBPR and we believe that this may be attributed to MDR1/ABCB1 encoded P-gp mediating the efflux of immunosuppressants out of leukocytes, with depleted immunosuppressant levels in leukocytes manifesting as increased cellular rejection.
A comparison of magnesium sulphate and sildenafil in the treatment of the newborns with persistent pulmonary hypertension: a randomized controlled trial.

The aim of this prospective, randomized and controlled study was to compare the clinical efficacy of intravenous magnesium sulfate (MgSO₄) and oral sildenafil therapies with persistent pulmonary hypertension of the newborn. A total of 34 infants in the MgSO₄ group and 31 infants in the sildenafil group completed the study. The time to reach the adequate clinical response [defined as oxygen index (OI) level of <15, a pulmonary artery pressure of < 20 mmHg) was significantly shorter in the sildenafil group (p = 0.002). Duration of mechanical ventilation was longer and the number of the patients requiring inotropic support was higher in the MgSO₄ group (p = 0.001 and p = 0.002, respectively). Although among two groups the difference in OI > 5 as speculated in our hypothesis could only be found at 36 h of the treatment, sildenafil was more effective than MgSO₄ in the treatment of persistent pulmonary hypertension of the newborns with regard to time to adequate clinical response, duration of mechanical ventilation and support requirement with inotropic agents.