Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of privacy concerns on consumers' acceptance of smart metering in the Netherlands

A number of initiatives are taking place in the European Union and US to roll out the smart metering system, as part of the smart grids in the energy sector. The motivation behind the system, among others, is to meet requirements from the Kyoto protocol and EU Energy Efficiency Directives. Among the obstacles impeding the system roll out is consumers' information security and privacy concerns. In this paper, privacy concerns are presented as social vulnerability and how it negatively impacts the system. The paper concludes with the findings of a predictive logistic regression model that was used to analyze a survey among residential electricity consumers in The Netherlands, which revealed consumers' tendencies to rejecting or accepting the system.
Efficient Algorithms for Non-gaussian Single Index Models with Generative Priors

In this work, we focus on high-dimensional single index models with non-Gaussian sensing vectors and generative priors. More specifically, our goal is to estimate the underlying signal from i.i. d. realizations of the semi-parameterized single index model, where the underlying signal is contained in (up to a constant scaling) the range of a Lipschitz continuous generative model with bounded low-dimensional inputs, the sensing vector follows a non-Gaussian distribution, the noise is a random variable that is independent of the sensing vector, and the unknown non-linear link function is differentiable. Using the first- and second-order Stein's identity, we introduce efficient algorithms to obtain estimated vectors that achieve the near-optimal statistical rate. Experimental results on image datasets are provided to support our theory.
Nitrous oxide does not change the incidence of postoperative delirium or cognitive decline in elderly surgical patients.

BACKGROUND Postoperative delirium and cognitive decline are common in elderly surgical patients after non-cardiac surgery. Despite this prevalence and clinical importance, no specific aetiological factor has been identified for postoperative delirium and cognitive decline. In experimental setting in a rat model, nitrous oxide (N(2)O) produces neurotoxic effect at high concentrations and in an age-dependent manner. Whether this neurotoxic response may be observed clinically has not been previously determined. We hypothesized that in the elderly patients undergoing non-cardiac surgery, exposure to N(2)O resulted in an increased incidence of postoperative delirium than would be expected for patients not receiving N(2)O. METHODS Patients who were >or=65 yr of age, undergoing non-cardiac surgery and requiring general anaesthesia were randomized to receive an inhalational agent and either N(2)O with oxygen or oxygen alone. A structured interview was conducted before operation and for the first two postoperative days to determine the presence of delirium using the Confusion Assessment Method. RESULTS A total of 228 patients were studied with a mean (range) age of 73.9 (65-95) yr. After operation, 43.8% of patients developed delirium. By multivariate logistic regression, age [odds ratio (OR) 1.07; 95% confidence interval (CI) 1.02-1.26], dependence on performing one or more independent activities of daily living (OR 1.54; 95% CI 1.01-2.35), use of patient-controlled analgesia for postoperative pain control (OR 3.75; 95% CI 1.27-11.01) and postoperative use of benzodiazepine (OR 2.29; 95% CI 1.21-4.36) were independently associated with an increased risk for postoperative delirium. In contrast, the use of N(2)O had no association with postoperative delirium. CONCLUSIONS Exposure to N(2)O resulted in an equal incidence of postoperative delirium when compared with no exposure to N(2)O.
β- and α-Cell Dysfunction in Subjects Developing Impaired Glucose Tolerance

OBJECTIVE— This study assessed insulin and glucagon secretion in relation to insulin sensitivity in Caucasian women who develop impaired glucose tolerance (IGT) versus those who maintain normal glucose tolerance (NGT) over a 12-year period. RESEARCH DESIGN AND METHODS— At baseline and after 3, 8, and 12 years, glucose tolerance (75-g oral glucose tolerance test), insulin sensitivity (euglycemic-hyperinsulinemic clamp), and insulin and glucagon secretion (2- to 5-min responses to 5 g arginine i.v. at fasting, 14 and >25 mmol/l glucose) were determined in 53 healthy Caucasian women (aged 58 years at baseline) who all had NGT at baseline. RESULTS— During the 12-year period, 26 subjects developed IGT, whereas the remaining 27 subjects maintained NGT throughout the 12-year period. Subjects developing IGT had lower insulin sensitivity than those maintaining NGT in the tests preceding diagnosis of IGT (P ≤ 0.05). When judged in relation to insulin sensitivity, β-cell glucose sensitivity and maximal insulin secretion were lower in those who later developed IGT than in those maintaining NGT at all tests (P ≤ 0.05). Furthermore, subjects who developed IGT had defective suppression of glucagon secretion by glucose in the test preceding diagnosis of IGT when they still had NGT (P ≤ 0.05). CONCLUSIONS— β- and α-cell dysfunction are evident several years before diagnosis of IGT, and islet dysfunction is manifested as impaired glucose sensitivity of the β- and α-cells and reduced maximal insulin secretion.
MRI: the new reference standard in quantifying hepatic steatosis?

Objective The purpose of this study was to assess non-invasive imaging modalities including MRI and CT and compare the quantitative amount of fat with data provided by the pathologist and a chemical lipid assay in leptin-deficient mouse livers. Methods A liver/fat phantom was first used to assess the accuracy of small-animal MRI and human MRI and CT, followed by correlation analysis with ob/ob mouse liver fat quantified by an accurate chemical lipid assay. Similarly, the authors compared the pathologist's quantification and the automated software quantification of fat with the lipid assay. The authors then investigated whether hepatic steatosis assessed by MRI correlates with the degree of liver injury in a model of ischaemia/reperfusion in leptin-deficient mice as well as with serious postoperative complications in patients undergoing major liver resection (NCT01234714). Results The authors designed lipid/liver mixtures at various ratios to mimic a wide range of fat liver contents. Small-animal and human MRI detected this fat with a high correlation to the actual fat contents. Mouse livers assessed by human MRI correlated best with total intrahepatic fat by chemical lipid analysis (r=0.975). Human CT, the pathologist's assessment and the automated software were less reliable (r=−0.873, 0.512 and 0.873, respectively). There was a significant correlation of the MRI fat quantification with several parameters of liver injury, and MRI data could predict mouse survival after ischaemia/reperfusion injury. In patients undergoing major liver resection, higher liver fat content was associated with more serious postoperative complications, such as liver or multiorgan failure and sepsis, necessitating admission to the intensive care unit. Conclusions With the use of a well-defined set of biological standards, MRI can predict intrahepatic fat with high accuracy. In contrast to biopsies, this method is non-invasive, giving a representative assessment of the whole liver.
Clinical correlates of charcot–marie–tooth disease in patients with pes cavus deformities

Introduction: Given its association with Charcot–Marie–Tooth disease (CMT), pes cavus is a common reason for referral to a neurologist. We investigated clinical features that may predict CMT in children with pes cavus. Methods: In this study we retrospectively reviewed pes cavus patients referred to Boston Children's Hospital in the past 20 years. Patients were categorized as idiopathic or CMT, based on EMG/genetic testing, and their clinical features were compared. Results: Of the 70 patients studied, 33 had idiopathic pes cavus, and 37 had genetically confirmed CMT. Symptoms of weakness, unsteady gait, family history of pes cavus and CMT, and signs of sensory deficits, distal atrophy and weakness, absent ankle jerks, and gait abnormalities were associated with CMT. Conclusions: In children with pes cavus, certain clinical features can predict CMT and assist in selection of patients for further, potentially uncomfortable (EMG) and expensive (genetic) confirmatory investigations. Muscle Nerve, 2013
Nuclear import of APOBEC3F-labeled HIV-1 preintegration complexes

Significance We observed that fluorescent protein-tagged host restriction factors APOBEC3F (A3F) and APOBEC3G (A3G) remain associated with HIV-1 preintegration complexes (PICs) in the nuclei of infected cells. Using A3F labeling as a tool to visualize PICs, we determined that (i) reverse transcription is not required for nuclear import of PICs, indicating that a viral core uncoating event associated with reverse transcription, and the central DNA flap that forms during reverse transcription, are not required for nuclear import; (ii) viral core stability mutations dramatically reduce association of PICs with the nuclear envelope as well as diminish their nuclear import; and (iii) most nuclear PICs remain close to the nuclear envelope and are not distributed throughout the nuclei. Human cytidine deaminases APOBEC3F (A3F) and APOBEC3G (A3G) are host factors that incorporate into virions and restrict virus replication. We labeled HIV-1 particles with yellow fluorescent protein (YFP)-tagged APOBEC3 proteins and examined their association with preintegration complexes (PICs) in infected cells. Labeling of PICs with A3F-YFP, and to a lesser extent A3G-YFP, could be used to visualize PICs in the nuclei, which was dependent on nuclear pore protein Nup153 but not TNPO3. We show that reverse transcription is not required for nuclear import of PICs, indicating that a viral core uncoating event associated with reverse transcription, and the central DNA flap that forms during reverse transcription, are not required for nuclear import. We also quantify association of cytoplasmic PICs with nuclear envelope (NE) and report that capsid mutations that increase or decrease core stability dramatically reduce NE association and nuclear import of PICs. In addition, we find that nuclear PICs remain close to the NE and are not distributed throughout the nuclei. These results provide tools for tracking retroviral PICs in infected cells and reveal insights into HIV-1 replication.
Image registration under local illumination variations using robust bisquare M-estimation

In this paper, we present a registration approach for images having arbitrarily-shaped locally variant illuminations. These variations tend to degrade the performance of geometric registration precision (GRP) and impact subsequent processing. Traditional registration approaches typically use a least-squares estimator that is sensitive to outliers. Instead, we propose using a robust bisquare M-estimator, as it differently penalizes the small and large residuals. The proposed approach shows clear improvements over competing approaches in terms of GRP and illumination correction, using simulated and real image pairs.
OX40-Mediated Differentiation to Effector Function Requires IL-2 Receptor Signaling but Not CD28, CD40, IL-12Rβ2, or T-bet1

Ag-specific CD4 T cells transferred into unirradiated Ag-bearing recipients proliferate, but survival and accumulation of proliferating cells is not extensive and the donor cells do not acquire effector functions. We previously showed that a single costimulatory signal delivered by an agonist Ab to OX40 (CD134) promotes accumulation of proliferating cells and promotes differentiation to effector CD4 T cells capable of secreting IFN-γ. In this study, we determined whether OX40 costimulation requires supporting costimulatory or differentiation signals to drive acquisition of effector T cell function. We report that OX40 engagement drives effector T cell differentiation in the absence of CD28 and CD40 signals. Two important regulators of Th1 differentiation, IL-12R and T-bet, also are not required for acquisition of effector function in CD4 T cells responsive to OX40 stimulation. Finally, we show that CD25-deficient CD4 T cells produce little IFN-γ in the presence of OX40 costimulation compared with wild type, suggesting that IL-2R signaling is required for efficient OX40-mediated differentiation to IFN-γ secretion.
Multi-modal tracking of faces for video communications

Visual processes to detect and track faces for video compression and transmission. The system is based on an architecture in which a supervisor selects and activates visual processes in cyclic manner. Control of visual processes is made possible by a confidence factor which accompanies each observation. Fusion of results into a unified estimation for tracking is made possible by estimating a covariance matrix with each observation. Visual processes for face tracking are described using blink detection, normalised color histogram matching, and cross correlation (SSD and NCC). Ensembles of visual processes are organised into processing states so as to provide robust tracking. Transition between states is determined by events detected by processes. The result of face detection is fed into recursive estimator (Kalman filter). The output from the estimator drives a PD controller for a pan/tilt/zoom camera. The resulting system provides robust and precise tracking which operates continuously at approximately 20 images per second on a 150 megahertz computer workstation.
Anal endosonography in the investigation of faecal incontinence

Forty‐four consecutive patients with incontinence of solid stool of traumatic or idiopathic aetiology were examined by anal endosonography and standard anorectal physiology tests. Anal endosonography showed an external anal sphincter defect in four out of 11 (36 per cent) patients with idiopathic (neurogenic) incontinence. In the remaining seven patients both parts of the sphincter were intact and a linear relationship was found between the resting anal canal pressure and the endosonographic thickness of the internal anal sphincter. Twenty‐eight out of 33 (85 per cent) patients with incontinence of traumatic origin had external sphincter defects, confirmed by concentric needle electromyogram mapping in the 19 patients in whom this was performed. Eleven of these 28 (39 per cent) patients also had disruption of the internal spincter. Anal endosonography has revealed significant abnormalities in patients with faecal incontinence and has a complementary role to anorectal physiology in the routine investigation of these patients.
The prevalence and clinical significance of sonographic tendon abnormalities in asymptomatic ballet dancers: a 24-month longitudinal study

Introduction Sonographic abnormalities of the achilles and patellar tendons are common findings in athletes, and tendinopathy is a common cause of pain and disability in athletes. However, it is unclear whether the sonographic changes are pathological or adaptive, or if they predict future injury. We undertook a cohort study to determine what sonographic features of the achilles and patellar tendons are consistent with changes as a result of ballet training, and which may be predictive of future development of disabling tendon symptoms. Methods The achilles and patellar tendons of 79 (35 male, 44 female) professional ballet dancers (members of the English Royal Ballet) were examined with ultrasound, measuring proximal and distal tendon diameters and assessing for the presence of hypoechoic change, intratendon defects, calcification and neovascularity. All subjects were followed for 24 months for the development of patellar tendon or achilles-related pain or injury severe enough to require time off from dancing. Results Sonographic abnormalities were common among dancers, both male and female, and in both achilles and patellar tendons. Disabling tendon-related symptoms developed in 10 dancers and 14 tendons: 7 achilles (3 right, 4 left) and 7 patellar (2 right, 5 left). The presence of moderate or severe hypoechoic defects was weakly predictive for the development of future disabling tendon symptoms (p=0.0381); there was no correlation between any of the other sonographic abnormalities and the development of symptoms. There was no relationship between achilles or patellar tendons’ diameter, either proximal or distal, with an increased likelihood of developing tendon-related disability. Conclusion The presence of sonographic abnormalities is common in ballet dancers, but only the presence of focal hypoechoic changes predicts the development of future tendon-related disability. This suggests that screening of asymptomatic individuals may be of use in identifying those who are at higher risk of developing tendon-related disability, which may in turn allow targeted modifications of training or other preventative regimens.
Periodontitis as a possible early sign of diabetes mellitus

Objective The early diagnosis of (pre)diabetes mellitus is essential for the prevention of diabetes complications. It has been suggested that gum disease (periodontitis) might be an early complication of diabetes and may be a useful risk indicator for diabetes screening. Therefore, a dental office could be a good location for screening for (pre)diabetes in patients with periodontitis using a validated glycated hemoglobin (HbA1c) dry spot analysis. Research design and methods A total of 313 individuals from a university dental clinic participated. From 126 patients with mild/moderate periodontitis, 78 patients with severe periodontitis and 109 subjects without periodontitis, HbA1c values were obtained by the analysis of dry blood spots. Differences in mean HbA1c values and the prevalence of (pre)diabetes between the groups were analyzed. Results The mild/moderate and severe periodontitis groups showed significantly higher HbA1c values (6.1%±1.4% (43 mmol/mol±15 mmol/mol) and 6.3%±1.3% (45 mmol/mol±15 mmol/mol), respectively) compared with the control group (5.7%±0.7% (39 mmol/mol±8 mmol/mol), p=0.003). In addition, according to the American Diabetes Association (ADA) guidelines for diagnosis, there was a significant over-representation of subjects with suspected diabetes (23% and 14%) and pre-diabetes (47% and 46%) in the severe periodontitis group and mild/moderate periodontitis groups, respectively, compared with the control group (10% and 37%, p=0.010). Notably, 18.1% of patients with suspected new diabetes were found among subjects with severe periodontitis compared with 9.9% and 8.5% among subjects with mild/moderate periodontitis and controls, respectively (p=0.024). Conclusions The dental office, with particular focus on patients with severe periodontitis, proved to be a suitable location for screening for (pre)diabetes; a considerable number of suspected new diabetes cases were identified. The early diagnosis and treatment of (pre)diabetes help to prevent more severe complications and benefit the treatment of periodontitis.
Comparative Study of Evapotranspiration Variation and its Relationship with other Climatic Parameters in Asaba and Uyo

This study was carried out to assess the variations of Reference Evapotranspiration (ETO also denoted with RET) calculated using FAO-56 Penman Monteith model of two locations Asaba and Uyo and evaluate its relationships with the variations of other climatic parameters. Meteorological data of forty one years (1975-2015) and thirty five years (1981-2015) period for Asaba and Uyo, respectively gotten from Nigeria Meteorological Agency, Abuja were used. It was observed that the variations of Evapotranspiration (ET) in both locations were in line with two seasons (rainy and dry) normally experienced in Nigeria having its highest value in March (4.8 mm/day) for Asaba and for Uyo in February (4.5 mm/day); and its lowest value in August (3.1 mm/day) for Asaba and in July (2.9 mm/day) for Uyo. ET variation when compared with other climatic variables in both locations was observed to have the same trend with maximum temperature, solar radiation and sunshine hours. It also has the same variation with minimum temperature though with slight deviation. It was observed that ET variation is inversely proportional to the variation relative humidity. Wind speed displayed relatively small variation in its trend over the study period and is not in line with the variations of ET.Keywords— Evapotranspiration, Climatic Variables, FAO Penman-Monteith Model, Variations
AACVPR/ACC/AHA 2007 performance measures on cardiac rehabilitation for referral to and delivery of cardiac rehabilitation/secondary prevention services.

adverse events during CR sessions. 54 However, 1 study found that a combination of the AACVPR criteria with a comorbidity index helped improve the accuracy of risk stratification, particularly among female patients. 55 A significant limitation to these studies is the fact that patients identified as high risk undergo additional evaluation and treatment to lower their risk, thereby dampening the ability of such screening measures to accurately identify individuals at increased risk of adverse cardiovascular events. This performance measure does not cover the assessment of modifiable risk factors, such as blood pressure, cholesterol, and diabetes. Assessment of modifiable risk factors related to CVD progression and recurrent CVD events is covered in Performance Measure B-3.
Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent

Human arylamine N-acetyltransferase 1 (NAT1) is a phase II cytosolic enzyme responsible for the activation or deactivation of many arylamine compounds including pharmaceuticals and environmental carcinogens. NAT1 is highly polymorphic and has been associated with altered risk toward many cancers. NAT1*14B is characterized by a single nucleotide polymorphism in the coding region (rs4986782; 560G>A; R187Q). NAT1*14B is associated with higher frequency of smoking-induced lung cancer and is the most common “slow acetylator” arylamine NAT1 genetic variant. Previous studies have reported decreased N- and O-acetylation capacity and increased proteasomal degradation of NAT1 14B compared with the referent, NAT1 4. The current study is the first to investigate NAT1*14B expression using constructs that completely mimic NAT1 mRNA by including the 5′- and 3′-untranslated regions, together with the open reading frame of the referent, NAT1*4, or variant, NAT1*14B. Our results show that NAT1 14B is not simply associated with “slow acetylation. ” NAT1 14B-catalyzed acetylation phenotype is substrate-dependent, and NAT1 14B exhibits higher N- and O-acetylation catalytic efficiency as well as DNA adducts after exposure to the human carcinogen 4-aminobiphenyl.