Miracle-dz/UniFAR-FTUs huggingface dataset:
Systemic cytotoxic and biological therapies of colorectal liver metastases: expert consensus statement.

Systemic therapy for colorectal cancer liver metastases (CRLM) has undergone significant development in the past 15 years. Therapy regimens consisting of combinations of cytotoxic chemotherapeutic agents have demonstrated greater efficacy and contributed to a significant survival improvement. As the majority of patients who undergo resection for liver-only CRLM are at risk of disease recurrence and cancer-related death, combining resection with systemic therapy appears sensible. However, trial-based evidence is sparse to support this concept. Peri-operative FOLFOX has demonstrated a progression-free survival benefit in a single Phase III trial; the safety of chemotherapy and subsequent operations was acceptable and only a few patients showed initial progression. Chemotherapy-associated liver injury (CALI), including sinusoidal obstruction syndrome and steatohepatitis, has been observed after cytotoxic therapy, and should have implications for chemotherapy plans prior to hepatectomy. In general, pre-operative chemotherapy should not extend beyond 3 months. For patients with unresectable liver-only CRLM, a response to chemotherapy could establish resectability and should be considered an initial treatment goal. In patients with unresectable CRLM, oxaliplatin- or irinotecan-containing combinations represent the standard options, although single-agent choices may be appropriate for individual patients. The addition of bevacizumab carries the potential for a greater response and possibly for reduced CALI risks. In tumours without K-ras mutations, anti-epidermal growth factor receptor (EGFR) agents are also reasonable choices for a greater response and improved survival outcomes. It is crucial that all systemic CRLM treatment decisions include proper definitions of treatment goals and endpoints, and are derived based on appropriate multidisciplinary considerations for other potentially applicable local or regional modalities.
Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population

Purpose Aldehyde dehydrogenase 2 (ALDH2) is a well-known gene involved in alcohol and aldehyde metabolism. Moreover, recent studies have reported associations between ALDH2 and age-related disorders. Benign prostate hyperplasia (BPH) is an age-related disorder and genetic factors may contribute to its onset. In this study, we investigated the association of a well-studied ALDH2 single nucleotide polymorphism (SNP), rs671, with the onset and clinical features of BPH. Methods A total of 222 BPH patients and 214 control subjects were genotyped. The clinical features of the BPH patients (prostate volume, prostate-specific antigen level, and International Prostatic Symptom Score) were analyzed. Results The results show that rs671 was only associated with the volume of BPH in genotype and allele frequencies (P<0.05). Conclusion We propose that rs671 is an Asian-specific SNP in ALDH2 that may affect the disease progression of BPH in the Korean population.
Imaging Optimization of Temporal Bones With Cochlear Implant Using a High-resolution Cone Beam CT and the Corresponding Effective Dose

Objective: To evaluate the impact of tube voltage, tube current, pulse number, and magnification factor on the image quality of a novel experimental set-up and the corresponding radiation. Materials and Methods: Six human temporal bones with cochlear implant were imaged using various tube voltages, tube currents, pulse numbers, and magnification. The effect of radiation was evaluated using a metaloxide semiconductor field-effect transistor (MOSFET) dosimeter device on an anthropomorphic RANDO RAN102 male head phantom. A copper and aluminum combination filter was used for hardware filtration. Results: Overall, 900 frames, 11 mA, and 88 kV provided the best image quality. In temporal bones imaged with the optimized parameters, the cochlea, osseous spiral lamina, modiolus, stapes, round window niche, and oval window landmarks were demonstrated with anatomic structures still fully assessable in all parts and acceptable image quality. The most dominant contributor to the effective dose was bone marrow (36%-37 %) followed by brain (34%-36%), remainder tissues (12%), extra-thoracic airways (7%), and oral mucosa (5%). Conclusions: By increasing the number of frames, the image quality of the inner ear details obtained using the novel cone-beam computed tomography improved.
Differential Maintenance of Cortical and Cancellous Bone Strength Following Discontinuation of Bone-Active Agents

Osteoporotic patients treated with antiresorptive or anabolic agents experience an increase in bone mass and a reduction in incident fractures. However, the effects of these medications on bone quality and strength after a prolonged discontinuation of treatment are not known. We evaluated these effects in an osteoporotic rat model. Six‐month‐old ovariectomized (OVX) rats were treated with placebo, alendronate (ALN, 2 µg/kg), parathyroid hormone [PTH(1–34); 20 µg/kg], or raloxifene (RAL, 2 mg/kg) three times a week for 4 months and withdrawn from the treatments for 8 months. Treatment with ALN, PTH, and RAL increased the vertebral trabecular bone volume (BV/TV) by 47%, 53%, and 31%, with corresponding increases in vertebral compression load by 27%, 51%, and 31%, respectively (p < .001). The resulting bone strength was similar to that of the sham‐OVX control group with ALN and RAL and higher (p < .001) with PTH treatment. After 4 months of withdrawal, bone turnover (BFR/BS) remained suppressed in the ALN group versus the OVX controls (p < .001). The vertebral strength was higher than in the OVX group only in ALN‐treated group (p < .05), whereas only the PTH‐treated animals showed a higher maximum load in tibial bending versus the OVX controls (p < .05). The vertebral BV/TV returned to the OVX group level in both the PTH and RAL groups 4 months after withdrawal but remained 25% higher than the OVX controls up to 8 months after withdrawal of ALN (p < .05). Interestingly, cortical bone mineral density increased only with PTH treatment (p < .05) but was not different among the experimental groups after withdrawal. At 8 months after treatment withdrawal, none of the treatment groups was different from the OVX control group for cortical or cancellous bone strength. In summary, both ALN and PTH maintained bone strength (maximum load) 4 months after discontinuation of treatment despite changes in bone mass and bone turnover; however, PTH maintained cortical bone strength, whereas ALN maintained cancellous bone strength. Additional studies on the long‐term effects on bone strength after discontinuation and with combination of osteoporosis medications are needed to improve our treatment of osteoporosis. © 2011 American Society for Bone and Mineral Research.
Cascade events at IceCube + DeepCore as a definitive constraint on the dark matter interpretation of the PAMELA and Fermi anomalies

Dark matter decaying or annihilating into μ^+μ^- or τ^+τ^- has been proposed as an explanation for the e^± anomalies reported by PAMELA and Fermi. Recent analyses show that IceCube, supplemented by DeepCore, will be able to significantly constrain the parameter space of decays to μ^+μ^-, and rule out decays to τ^+τ^- and annihilations to μ^+μ^- in less than five years of running. These analyses rely on measuring tracklike events in IceCube + DeepCore from down-going ν_μ. In this paper we show that by instead measuring cascade events, which are induced by all neutrino flavors, IceCube + DeepCore can rule out decays to μ^+μ^- in only three years of running, and rule out decays to τ^+τ^- and annihilation to μ^+μ^- in only one year of running. These constraints are highly robust to the choice of dark matter halo profile and independent of dark matter-nucleon crosssection.
Effects of an Attractive Sink Leading into Maladaptive Habitat Selection

Habitat sinks can attract dispersing animals if high mortality or breeding failure are difficult to detect (e.g., when due to human hunting or pollution). Using a simple deterministic model, we explore the dynamics of such source‐sink systems considering three scenarios: an avoided sink, no habitat preference, and an attractive sink. In the second two scenarios, there is a threshold proportion of sink habitat above which the whole population decreases to extinction, but this extinction threshold varies with habitat preference and the relative qualities of the two habitat types. Hence, it would be necessary to know the habitat preferences of any species in a source‐sink system to interpret data on population increases and declines. In the attractive sink scenario, small changes in the proportion of sink habitat may have disproportionate effects on the population persistence. Also, small changes in growth rates at the source and the sink severely affect the threshold and the time of extinction. For some combinations of demographic parameters and proportion of habitat sink, the decline affects the source first; thus, during some time, it will be hidden to population monitoring at the sink, where numbers can even increase. The extinction threshold is also very sensitive to the initial population sizes relative to carrying capacity. Attractive sinks represent a novel aspect of source‐sink dynamics with important conservation and management implications.
Thyroid nodules with isolated macrocalcification: malignancy risk and diagnostic efficacy of fine-needle aspiration and core needle biopsy

Purpose: This study was performed to determine the malignancy risk of thyroid nodules with isolated macrocalcification and to evaluate the diagnostic efficacy of fine-needle aspiration (FNA) and core needle biopsy (CNB). Methods: From May 2008 to December 2014, a total of 44 patients with isolated macrocalcifications were enrolled from 4,081 consecutive patients who underwent FNA or CNB at a single institution. We assessed the malignancy risk of nodules with isolated macrocalcification. We compared the diagnostic results between FNA and CNB, and the diagnostic efficacy of each procedure was evaluated by the rate of inconclusive results. We compared the diagnostic performance for malignancy between FNA and CNB with a criterion of malignant or atypia/follicular lesion of undetermined significance (indeterminate) diagnostic results. We investigated whether the ultrasonographic feature of isolated macrocalcification was predictive of malignancy. Results: The malignancy risk of nodules with isolated macrocalcification was 16.1% in 31 nodules with final diagnoses and 11.4% in all nodules. CNB demonstrated a significantly lower rate of nondiagnostic and inconclusive results than FNA (7.7% vs. 53.8%, P=0.002 and 15.4% vs. 57.7%, P=0.003, respectively) in 26 nodules that underwent both FNA and CNB. CNB showed a marginally higher diagnostic performance for identifying malignancy than FNA (P=0.067). The ultrasonographic features of the anterior margin of isolated macrocalcification were not predictive of malignancy (P>0.999). Conclusion: Thyroid nodules with isolated macrocalcification had a low to intermediate malignancy risk and should not be considered benign nodules. CNB showed a higher diagnostic efficacy than FNA in these nodules.
Horn-Schunck Optical Flow with a Multi-Scale Strategy

The seminal work of Horn and Schunck is the first variational method for optical flow estimation. It introduced a novel framework where the optical flow is computed as the solution of a minimization problem. From the assumption that pixel intensities do not change over time, the optical flow constraint equation is derived. This equation relates the optical flow with the derivatives of the image. There are infinitely many vector fields that satisfy the optical flow constraint, thus the problem is ill-posed. To overcome this problem, Horn and Schunck introduced an additional regularity condition that restricts the possible solutions. Their method minimizes both the optical flow constraint and the magnitude of the variations of the flow field, producing smooth vector fields. One of the limitations of this method is that, typically, it can only estimate small motions. In the presence of large displacements, this method fails when the gradient of the image is not smooth enough. In this work, we describe an implementation of the original Horn and Schunck method and also introduce a multi-scale strategy in order to deal with larger displacements. For this multi-scale strategy, we create a pyramidal structure of downsampled images and change the optical flow constraint equation with a nonlinear formulation. In order to tackle this nonlinear formula, we linearize it and solve the method iteratively in each scale. In this sense, there are two common approaches: one that computes the motion increment in the iterations; or the one we follow, that computes the full flow during the iterations. The solutions are incrementally refined over the scales. This pyramidal structure is a standard tool in many optical flow methods.
Further evidence of tetragonality in bainitic ferrite

Abstract There is growing evidence that bainitic ferrite which retains a substantial amount of carbon in solid solution does not have cubic symmetry. We provide additional data on a different nanostructured bainitic steel to support this evidence, based on synchrotron X-ray diffraction experiments. The data are consistent only with a displacive transformation mechanism for bainite.
Nanophotonics using a subwavelength aperture in a metal film

Abstract This review focuses on the optical theory and applications of a single subwavelength aperture in a metal film. We begin with Bethe’s aperture theory for the optical transmission through a subwavelength aperture in a perfect electric conductor film and extend the discussion to apertures in real metals of finite thickness and to apertures with different shapes. Extraordinary optical transmission (EOT) is reviewed, particularly for an aperture in a transverse waveguide screen and for waveguide EOT with applications to aperture near-field probes. We overview applications of single subwavelength nanoapertures to refractive index sensing, single molecule fluorescence detection, Raman spectroscopy and optical trapping of dielectric nanoparticles, including biological matter. Finally, we discuss the potential of combining these many different capabilities to create greater functionality with a single aperture.
Renal expression and urinary concentration of EGF and IL-6 in acutely dysfunctioning kidney transplanted patients.

BACKGROUND Despite marked improvements in the success of solid organ transplantation, a significant percentage of transplanted organs is lost due to recurrent episodes of acute cellular rejection. The mechanisms that govern allograft rejection likely include a complex regulatory network of multiple cytokines and growth factors. DESIGN AND METHOD This study investigated the kidney gene (in situ hybridization) and protein (immunohistochemistry) expression and the urinary excretion rate of IL-6 and EGF in 29 renal transplant recipients: 16 with acute cellular rejection (AR) and 13 with acute tubular damage/cyclosporine toxicity (ATD). RESULTS AR patients displayed a 4-fold increase of renal IL-6 expression, which localized chiefly to proximal tubular cells and monocytes/macrophages, whereas EGF signal was extremely weak or even absent. In ATD patients, EGF expression was markedly reduced, while IL-6 specific signal was unchanged. In all the patients examined the renal expression of IL-6 and EGF strictly correlated with their urinary excretion rate (r:0.459, P:0.001). Thus, urinary IL-6/EGF ratio was markedly increased in the former group (> 20-fold at day 1), where it paralleled the modifications of plasma creatinine over time (r:0.603, P < 0.0001), and was only slightly increased in the latter group (< 3-fold). CONCLUSION Kidney transplanted patients with acute cellular rejection or acute tubular damage/CyA nephrotoxicity exhibit a distinctly different pattern of intragraft expression of IL-6 and EGF, which is closely reflected by their rate of urinary excretion.
The clustering of merging star-forming haloes: dust emission as high frequency arcminute CMB foreground

Context. Future observations of CMB anisotropies will be able to probe high multipole regions of the angular power spectrum, corresponding to a resolution of a few arcminutes. Dust emission from merging haloes is one of the foregrounds that will affect such very small scales. Aims. We estimate the contribution to CMB angular fluctuations from objects that are bright in the sub-millimeter band due to intense star formation bursts following merging episodes. Methods. We base our approach on the Lacey-Cole merger model and on the Kennicutt relation which connects the star formation rate in galaxies with their infrared luminosity. We set the free parameters of the model in order to not exceed the SCUBA source counts, the Madau plot of star formation rate in the universe and COBE/FIRAS data on the intensity of the sub-millimeter cosmic background radiation. Results. We show that the angular power spectrum arising from the distribution of such star-forming haloes will be one of the most significant foregrounds in the high frequency channels of future CMB experiments, such as PLANCK, ACT and SPT. The correlation term, due to the clustering of multiple haloes at redshift z ∼ 2-6, is dominant in the broad range of angular scales 200? I? 3000. Poisson fluctuations due to bright sub-millimeter sources are more important at higher l, but since they are generated from the bright sources, such contribution could be strongly reduced if bright sources are excised from the sky maps. The contribution of the correlation term to the angular power spectrum depends strongly on the redshift evolution of the escape fraction of UV photons and the resulting temperature of the dust. The measurement of this signal will therefore give important information about the sub-millimeter emission and the escape fraction of UV photons from galaxies, in the early stage of their evolution.
A Comparison of Plates With and Without Locking Screws in a Calcaneal Fracture Model

Background: We compared different plates in an experimental calcaneal fracture model under biocompatible loading. Methods: Four plates were tested: a plate without locked screws (Synthes), and three different plates with locked screws (Newdeal, Darco, Synthes). Synthetic calcanei (Sawbone) were osteotomized to create a fracture model, and the plates were fixed onto them. Seven specimens for each plate model were subjected to cyclic loading (preload 20 N, 1,000 cycles with 800 N, 0.75 mm/s), and load to failure (0.75 mm/s). Motion, forces, plastic deformation of the plate, and consequent depression of the posterior joint facet were analyzed. Results: During cyclic loading, all plates with locked screws showed statistically significant lower displacement in the primary loading direction than the plates without locked screws. Mean values (mm) of maximal displacements for each plate during cyclic loading were as follows: Synthes, 3.5; Darco, 4.5; Newdeal, 5.0; Synthes without locked screws, 7.5; (p < 0.001). No statistically significant differences between the plates were found in relation to loads to failure and corresponding displacement. Conclusion: This is the first biomechanical study to assess the stability of different plates currently in use in our practice for the fixation of calcaneal fractures. Our results showed that plates with locked screws provided greater stability during cyclic loading than the plate without locked screws.
How Social Media Reduces Mass Political Polarization. Evidence from Germany, Spain, and the U.S.

A growing proportion of citizens rely on social media to gather political information and to engage in political discussions within their personal networks. Existing studies argue that social media create “echo-chambers,” where individuals are primarily exposed to like-minded views. However, this literature has ignored that social media platforms facilitate exposure to messages from those with whom individuals have weak ties, which are more likely to provide novel information to which individuals would not be exposed otherwise through ofﬂine interactions. Because weak ties tend to be with people who are more politically heterogeneous than citizens’ immediate personal networks, this exposure reduces political extremism. To test this hypothesis, I develop a new method to estimate dynamic ideal points for social media users. I apply this method to measure the ideological positions of millions of individuals in Germany, Spain, and the United States over time, as well as the ideological composition of their personal networks. Results from this panel design show that most social media users are embedded in ideologically diverse networks, and that exposure to political diversity has a positive effect on political moderation. This result is robust to the inclusion of covariates measuring ofﬂine political behavior, obtained by matching Twitter user proﬁles with publicly available voter ﬁles in several U.S. states. I also provide evidence from survey data in these three countries that bolsters these ﬁndings. Contrary to conventional wisdom, my analysis provides evidence that social media usage reduces mass political polarization.
Chlamydia screening interventions from community pharmacies: a systematic review.

BACKGROUND Chlamydia (Chlamydia trachomatis) is the most commonly notified sexually transmissible infection in Australia. Increasing the number of people aged 16-25 years being tested for chlamydia has become a key objective. The strategy recommends that chlamydia screening sites should be easy to access. Community pharmacies are conveniently located and easily accessible. This review aimed to determine the different types of pharmacy-based chlamydia screening interventions, describe their uptake rates, and understand issues around the acceptability of and barriers to testing. METHODS Seven electronic databases were searched for peer-reviewed articles published up to 30 October 2011 for studies that reported chlamydia screening interventions from community pharmacies, or had qualitative evidence on acceptability or barriers linked with interventions. RESULTS Of the 163 publications identified, 12 met the inclusion criteria. Nine reported chlamydia screening interventions in a pharmacy setting, whereas three focussed on perspectives on chlamydia screening. Pharmacists could offer a chlamydia test to consumers attending the pharmacy for a sexual health-related consultation, or consumers could request a chlamydia test as part of a population-based intervention. Participating consumers said pharmacies were accessible and convenient, and pharmacists were competent when offering a chlamydia test. Pharmacists reported selectively offering tests to women they thought would be most at risk, undermining the principles of opportunistic interventions. CONCLUSION Chlamydia screening from community pharmacies is feasible, and can provide an accessible, convenient venue to get a test. Professional implementation support, alongside resources, education and training programs, and incentives may overcome the issue of pharmacists selectively offering the test.