Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Impossibility of Informationally Efficient Markets

If competitive equilibrium is defined as a situation in which prices are such that all arbitrage profits are eliminated, is it possible that a competitive economy always be in equilibrium? Clearly not, for then those who arbitrage make no (private) return from their (privately) costly activity. Hence the assumptions that all markets, including that for information, are always in equilibrium and always perfectly arbitraged are inconsistent when arbitrage is costly. We propose here a model in which there is an equilibrium degree of disequilibrium: prices reflect the information of informed individuals (arbitrageurs) but only partially, so that those who expend resources to obtain information do receive compensation. How informative the price system is depends on the number of individuals who are informed; but the number of individuals who are informed is itself an endogenous variable in the model. The model is the simplest one in which prices perform a well-articulated role in conveying information from the informed to the uninformed. When informed individuals observe information that the return to a security is going to be high, they bid its price up, and conversely when they observe information that the return is going to be low. Thus the price system makes publicly available the information obtained by informed individuals to the uninformed. In general, however, it does this imperfectly; this is perhaps lucky, for were it to do it perfectly , an equilibrium would not exist. In the introduction, we shall discuss the general methodology and present some conjectures concerning certain properties of the equilibrium. The remaining analytic sections of the paper are devoted to analyzing in detail an important example of our general model, in which our conjectures concerning the nature of the equilibrium can be shown to be correct. We conclude with a discussion of the implications of our approach and results, with particular emphasis on the relationship of our results to the literature on "efficient capital markets. "
The effect of preprocessing in dynamic functional network connectivity used to classify mild traumatic brain injury

Dynamic functional network connectivity (dFNC), derived from magnetic resonance imaging (fMRI), is an important technique in the search for biomarkers of brain diseases such as mild traumatic brain injury (mTBI). At the individual level, mTBI can affect cognitive functions and change personality traits. Previous research aimed at detecting significant changes in the dFNC of mTBI subjects. However, one of the main concerns in dFNC analysis is the appropriateness of methods used to correct for subject movement. In this work, we focus on the effect that rearranging movement correction at different points of the processing pipeline has in dFNC analysis utilizing mTBI data.
Interaction between inflammation, mineral metabolism and the renin-angiotensin system: implications for cardiorenal outcomes in chronic kidney disease.

Progressive renal function loss is accompanied by deregulation of several key endocrine systems in the body, including the renin–angiotensin system (RAS). RAS activation, characterized by high levels of the major effector molecules angiotensin II and aldosterone, contributes to further aggravation of kidney damage through, among others, transforming growth factor b (TGF-b ). Moreover, it promotes cardiovascular disease through, among others, sodium retention and vasoconstriction, leading to hypertension. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) provide clear cardiorenal protection, strongly underlining the clinical relevance of the RAS in chronic kidney disease (CKD).
Influence of Vertical Result in Web Search Examination

Research in how users examine results on search engine result pages (SERPs) helps improve result ranking, advertisement placement, performance evaluation and search UI design. Although examination behavior on organic search results (also known as "ten blue links") has been well studied in existing works, there lacks a thorough investigation on how users examine SERPs with verticals. Considering the fact that a large fraction of SERPs are served with one or more verticals in the practical Web search scenario, it is of vital importance to understand the influence of vertical results on search examination behaviors. In this paper, we focus on five popular vertical types and try to study their influences on users' examination processes in both cases when they are relevant or irrelevant to the search queries. With examination behavior data collected with an eye-tracking device, we show the existence of vertical-aware user behavior effects including vertical attraction effect, examination cut-off effect in the presence of a relevant vertical, and examination spill-over effect in the presence of an irrelevant vertical. Furthermore, we are also among the first to systematically investigate the internal examination behavior within the vertical results. We believe that this work will promote our understanding of user interactions with federated search engines and bring benefit to the construction of search performance evaluations.
Ciprofloxacin-resistant Escherichia coli from bacteraemias in England; increasingly prevalent and mostly from men.

OBJECTIVES To assess ciprofloxacin resistance among Escherichia coli isolates from bacteraemia patients in England in relation to age, sex and Region. METHODS Routine susceptibility data for bacteraemia isolates were collected from over 90% of hospitals in England. RESULTS During 1995-2001, the prevalence of ciprofloxacin resistance trebled, from 2.1% to 6.5%. Isolates from men were more frequently resistant than those from women, possibly because infections in men more often involve nosocomial strains. Resistance was rare (<1.5%) in isolates from patients aged <1 year; among older patients, resistance was unrelated to age in isolates from women, but peaked in the 15-44 age group for men. CONCLUSIONS The prevalence of ciprofloxacin resistance in E. coli from bacteraemia is strongly associated with sex and, to a lesser extent, age.
Service load balancing, task scheduling and transportation optimisation in cloud manufacturing by applying queuing system

ABSTRACT Recently, there is a great deal of attention in Cloud Manufacturing (CMfg) as a new service-oriented manufacturing paradigm. To integrate the activities and services through a CMfg, both Service Load balancing and Transportation Optimisation (SLTO) are two major issues to ease the success of CMfg. Based on this motivation, this study presents a new queuing network for parallel scheduling of multiple processes and orders from customers to be supplied. Another main contribution of this paper is a new heuristic algorithm based on the process time of the tasks of the orders (LBPT) to solve the proposed problem. To formulate it, a novel multi-objective mathematical model as a Mixed Integer Linear Programming (MILP) is developed. Accordingly, this study employs the multi-choice multi-objective goal programming with a utility function to model the introduced SLTO problem. To better solve the problem, a Particle Swarm Optimisation (PSO) algorithm is developed to tackle this optimisation problem. Finally, a comparative study with different analyses through four scenarios demonstrates that there are some improvements on the sum of process and transportation costs by 6.1%, the sum of process and transportation times by 10.6%, and the service load disparity by 48.6% relative to the benchmark scenario.
No change in [11C]CUMI‐101 binding to 5‐HT1A receptors after intravenous citalopram in human

The main objective of this study was to determine the sensitivity of [11C]CUMI‐101 to citalopram challenge aiming at increasing extracellular 5‐HT. CUMI‐101 has agonistic properties in human embryonic kidney 293 cells transfected with human recombinant 5‐HT1A receptors (Hendry et al. [2011] Nucl Med Biol 38:273–277; Kumar et al. [2006] J Med Chem 49:125–134) and has previously been demonstrated to be sensitive to bolus citalopram in monkeys (Milak et al. [2011] J Cereb Blood Flow Metab 31:243–249). We studied six healthy individuals. Two PET‐scans were performed on the same day in each individual before and after constant infusion of citalopram (0.15 mg/kg). The imaging data were analyzed using two tissue compartment kinetic modeling with metabolite corrected arterial input and Simplified Reference Tissue Modeling using cerebellum as a reference region. There was no significant difference in regional distribution volume or non‐displaceable binding potential values before and after citalopram infusion. The mean receptor occupancy was 0.03 (range −0.14 to 0.17). Our data imply that [11C]CUMI‐101 binding is not sensitive to citalopram infusion in humans. Synapse, 2012. © 2012 Wiley Periodicals, Inc.
Exercise Training Program and Telenursing Effects on Depression and Fatigue Level in B- Thalathemia Major Children

Background: B-Thalassemia major considered as a serious life-threatening disease for pediatric population that causes substantial disruption in all aspects of child life. With advanced, effective management and even cure of thalassemia become possible, attention is drawn to the evaluation of depression and fatigue that accompany suffering children. Aims: investigate the effects of exercise training program combined with 3 months nurse –telephone follow up calls on depression and fatigue level in children with B-thalassemia major. Design and Method: A quasi experimental study was conducted on 60 thalassemic children who selected randomly after fulfilling the criteria of selection at hematology outpatient clinic of mansoura university children's hospital using three tools of data collection; structured interview questionnaire, depression inventory and fatigue scale. Exercise training either aerobic and anaerobic types was specific for the study subjects and they were followed by telephone follow up calls for three months by the researchers. Results: All thalassemic children suffer from depression with different categories and 95% of them suffer from fatigue before intervention. With telenursing follow up calls the total score of depression and fatigue were decreased after one month of exercise performance than before and continuously decreased after three months of exercise performance. Conclusion: The exercise training program combined by follow up calls was effective in decreasing depression and fatigue among thalassemic children after one and three months of intervention. Recommendation: It is suggested for performing and training the regular exercises as a routine care for those pediatric population.
Alcohol Use Disorder and Mortality Across the Lifespan: A Longitudinal Cohort and Co-relative Analysis.

IMPORTANCE Excess alcohol consumption and alcohol use disorders (AUDs) are associated with substantially increased mortality. Efforts to reduce this toll require an understanding of their causes. OBJECTIVE To clarify the degree to which the excess mortality associated with AUDs arises (1) from the predispositions of the person who develops AUD (and which would likely be shared by close relatives) and (2) as a direct result of AUD itself. DESIGN, SETTING, AND PARTICIPANTS A prospective cohort and co-relative design study involving all individuals born in Sweden from 1940 to 1965 who had neither died nor migrated prior to 1973 or age 15 years (N = 2 821 036). They were followed up from January 1, 1973, until December 31, 2010. Alcohol use disorder was assessed from medical, criminal, and pharmacy registries. Half-siblings, full-siblings, and monozygotic twin pairs discordant for AUD were obtained from the Multi-Generation and Twin Register. MAIN OUTCOME AND MEASURE Death obtained from the Swedish Death registry. RESULTS Our cohort (1 447 887 males and 1 373 149 females) included 131 895 males and 42 163 females registered with AUD. The mean (SD) age at first AUD registration was 39 (13.4) years. We ascertained 127 347 and 76 325 deaths in the male and female subsamples, respectively. Controlling for sex, educational status, and year of birth, the mortality hazard ratio associated with AUD was 5.83 (95% CI, 5.76-5.90) and varied-with an inverted U-shaped function-by age. Examining the AUD-mortality association in the general population and in relative pairs discordant for AUD exposure demonstrated substantial familial confounding in early to mid-adulthood: the AUD-associated mortality hazard ratio was much lower in discordant close relatives than in the general population. In middle to late adulthood, evidence for familial confounding decreased with increasing evidence for a direct effect of AUD on elevated mortality. In the oldest age group (65-70 years), the mortality hazard ratios were similar across the population and all relative pairs, suggesting that the excess mortality was largely a result of having AUD. Adding years since onset of AUD to the model showed that both increasing age and increasing years of duration of AUD contributed to the reduction of familial confounding in the association between AUD and elevated mortality. CONCLUSIONS AND RELEVANCE Excess mortality associated with AUD arises both from the predispositions of the person who develops AUD and the direct result of having AUD. The effect of predisposition is more prominent early in the life course and in the early years of AUD. The direct effect of AUD becomes progressively more important later in life and with longer duration of AUD. These results have implications for interventions seeking to reduce the elevated AUD-associated mortality.
The Impact of IELTS Scores on Performance at University

This paper considered two key issues. First, the relationship between English language proficiency, as measured by IELTS tests scores, and performance at University, as measured by Grade Point Average (GPA), was investigated using multi-level analysis. A significant and positive relationship was found. Second, the trade-off between raising IELTS entry scores and the consequent loss of international students was investigated at one South Australian university. Recommendations for raising IELTS scores for undergraduate and postgraduate students were made in the paper although it was recognised that on financial grounds the loss of international students might be too large to justify the increase in minimum English proficiency standards.
Association between birth weight and visceral fat in adults.

BACKGROUND Several studies reported inverse associations between birth weight and central adiposity in adults. However, few studies investigated the contributions of different abdominal fat compartments. OBJECTIVE We examined associations between birth weight and adult visceral and subcutaneous abdominal fat in the population-based Fenland study. DESIGN A total of 1092 adults (437 men and 655 women) aged 30-55 y had available data on reported birth weight, standard anthropometric measures, and visceral and subcutaneous abdominal fat estimated by ultrasound. In a subgroup (n = 766), dual-energy X-ray absorptiometry assessment of total abdominal fat was performed. Linear regression models were used to analyze relations between birth weight and the various fat variables adjusted for sex, age, education, smoking, and body mass index (BMI). RESULTS After adjustment for adult BMI, there was an inverse association between birth weight and total abdominal fat [B (partial regression coefficient expressed as SD/1-kg change in birth weight) = -0.09, P = 0.002] and visceral fat (B = -0.07, P = 0.01) but not between birth weight and subcutaneous abdominal fat (B = -0.01, P = 0.3). Tests for interaction showed that adult BMI modified the association between birth weight and visceral fat (P for interaction = 0.01). In stratified analysis, the association between birth weight and visceral fat was apparent only in individuals with the highest BMI tertile (B = -0.08, P = 0.04). CONCLUSIONS The inverse association between birth weight and adult abdominal fat appeared to be specific to visceral fat. However, associations with birth weight were apparent only after adjustment for adult BMI. Therefore, we suggest that rapid postnatal weight gain, rather than birth weight alone, leads to increased visceral fat.
Long-term Subcutaneous Protein C Replacement in Neonatal Severe Protein C Deficiency

We describe here the case of a boy who presented 2 days after birth with purpura fulminans on his feet and scalp. Laboratory investigations revealed signs of disseminated intravascular coagulation. An underlying coagulation disorder was suspected, and therapy with recombinant tissue plasminogen activator, fresh-frozen plasma, and unfractionated heparin was started. On the basis of plasma protein C activity and antigen levels of 0.02 and 0.03 IU/mL, respectively, after administration of fresh-frozen plasma, a diagnosis of severe protein C deficiency was established, and therapy with intravenous protein C concentrate (Ceprotin [Baxter, Deerfield, IL]) was started. Because of difficulties with venous access, we switched to subcutaneous administration after 6 weeks. The precise dosing schedule for subcutaneously administered protein C concentrate is unknown. In the literature, a trough level of protein C activity at >0.25 IU/mL is recommended to prevent recurrent thrombosis. During 1 year of follow-up our patient frequently had protein C activity levels at <0.25 IU/mL. Clinically, however, there was no recurrent thrombosis, and we kept the dosage unchanged. This report highlights 2 important points: (1) subcutaneously administered protein C concentrate is effective in treating severe protein C deficiency; and (2) in accordance with previous studies, after the acute phase trough levels of protein C activity at >0.25 IU/mL may not be necessary to prevent recurrent thrombosis. However, further research on the dosing, efficacy, and safety of protein C concentrate for prophylaxis and treatment of severe protein C deficiency is needed.
Expression patterns of vitamin D receptor in human prostate

UV exposure and serum levels of vitamin D have been linked in several studies with prostate cancer risk. At the cellular level, the principal action of vitamin D is mediated though vitamin D receptors (VDR). Since prostate cancer is a disease strongly associated with age, we examined the presence of VDR in normal prostate from donors of various ages to determine if the VDR expression pattern changed with age. We also compared the VDR expression in the peripheral and central zones of the prostate to determine if the expression pattern varied by location. Immunohistochemical studies were performed on paraffin‐embedded tissue from cases selected by the following age decades; 10–19, 20–29, 30–39, 40–49, 50–59, and 60–69. Both the central and peripheral zones were examined for VDR expression. The intensity of VDR expression in prostate was compared with expression in different types of human tissues. Mean VDR expression was lowest in the 10–19 years of age group. The intensity of the nuclear VDR was higher though the fifth decade, and then declined in cases of ages 60–70. When multiple sections of the same donor prostate were compared, VDR expression was greater in the peripheral zone compared to the central zone. J. Cell. Biochem. 82: 566–572, 2001. © 2001 Wiley‐Liss, Inc.
Towards automatic language processing and intonational labeling in European Portuguese

This work describes a framework that encompasses multi-layered linguistic information, focusing on prosodic features (pitch, energy, and tempo patterns), uses such features to distinguish between sentence-form types and disfluency/fluency repairs, and contributes to the characterization of intonational patterns of spontaneous and prepared speech in European Portuguese. Different machine learning methods have been applied for discriminating between structural metadata events, both in university lectures and in map-task dialogues, containing large amounts of spontaneous speech. Results show that prosodic features, and particularly a set of very informative features, are crucial to distinguish between sentence-form types and disfluency/fluency repair events. This is the first work for European Portuguese on both fully automatic processing of multi-layered linguistically description of spoken corpora and intonational labeling.
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62

SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening paradigm exploiting CRISPR-mediated genome editing coupled to a cell selection step by FACS to identify regulators of SQSTM1. Through systematic comparison of pooled libraries, we show that CRISPR is superior to RNAi in identifying known SQSTM1 modulators. A genome-wide CRISPR screen exposed MTOR signalling and the entire macroautophagy machinery as key regulators of SQSTM1 and identified several novel modulators including HNRNPM, SLC39A14, SRRD, PGK1 and the ufmylation cascade. We show that ufmylation regulates SQSTM1 by eliciting a cell type-specific ER stress response which induces SQSTM1 expression and results in its accumulation in the cytosol. This study validates pooled CRISPR screening as a powerful method to map the repertoire of cellular pathways that regulate the fate of an individual target protein. DOI: http://dx.doi. org/10.7554/eLife.17290. 001
Molecular paleontology and complexity in the last eukaryotic common ancestor

Abstract Eukaryogenesis, the origin of the eukaryotic cell, represents one of the fundamental evolutionary transitions in the history of life on earth. This event, which is estimated to have occurred over one billion years ago, remains rather poorly understood. While some well-validated examples of fossil microbial eukaryotes for this time frame have been described, these can provide only basic morphology and the molecular machinery present in these organisms has remained unknown. Complete and partial genomic information has begun to fill this gap, and is being used to trace proteins and cellular traits to their roots and to provide unprecedented levels of resolution of structures, metabolic pathways and capabilities of organisms at these earliest points within the eukaryotic lineage. This is essentially allowing a molecular paleontology. What has emerged from these studies is spectacular cellular complexity prior to expansion of the eukaryotic lineages. Multiple reconstructed cellular systems indicate a very sophisticated biology, which by implication arose following the initial eukaryogenesis event but prior to eukaryotic radiation and provides a challenge in terms of explaining how these early eukaryotes arose and in understanding how they lived. Here, we provide brief overviews of several cellular systems and the major emerging conclusions, together with predictions for subsequent directions in evolution leading to extant taxa. We also consider what these reconstructions suggest about the life styles and capabilities of these earliest eukaryotes and the period of evolution between the radiation of eukaryotes and the eukaryogenesis event itself.
A Relationship between Nuclear Black Hole Mass and Galaxy Velocity Dispersion

We describe a correlation between the mass Mbh of a galaxy's central black hole and the luminosity-weighted line-of-sight velocity dispersion σe within the half-light radius. The result is based on a sample of 26 galaxies, including 13 galaxies with new determinations of black hole masses from Hubble Space Telescope measurements of stellar kinematics. The best-fit correlation is Mbh = 1.2(±0.2) × 108 M☉(σe/200 km s-1)3.75 (±0.3) over almost 3 orders of magnitude in Mbh; the scatter in Mbh at fixed σe is only 0.30 dex, and most of this is due to observational errors. The Mbh-σe relation is of interest not only for its strong predictive power but also because it implies that central black hole mass is constrained by and closely related to properties of the host galaxy's bulge.