Miracle-dz/UniFAR-FTUs huggingface dataset:
Are Developers Fixing Their Own Bugs?: Tracing Bug-Fixing and Bug-Seeding Committers

The process of fixing software bugs plays a key role in the maintenance activities of a software project. Ideally, code ownership and responsibility should be enforced among developers working on the same artifacts, so that those introducing buggy code could also contribute to its fix. However, especially in FLOSS projects, this mechanism is not clearly understood: in particular, it is not known whether those contributors fixing a bug are the same introducing and seeding it in the first place. This paper analyzes the comm-central FLOSS project, which hosts part of the Thunderbird, SeaMonkey, Lightning extensions and Sunbird projects from the Mozilla community. The analysis is focused at the level of lines of code and it uses the information stored in the source code management system. The results of this study show that in 80% of the cases, the bug-fixing activity involves source code modified by at most two developers. It also emerges that the developers fixing the bug are only responsible for 3.5% of the previous modifications to the lines affected; this implies that the other developers making changes to those lines could have made that fix. In most of the cases the bug fixing process in comm-central is not carried out by the same developers than those who seeded the buggy code.
Axial-flux vs. radial-flux permanent-magnet synchronous generators for micro-wind turbine application

This paper presents a comparative study between the axial-flux and radial-flux permanent-magnet synchronous generators for a 3 kW wind turbine application. This study emphasizes the most cost-effective solution to be implemented by the industrial partner. There are three constructive types of electric generators considered in this work. All are based on permanent-magnet synchronous generators (PMSGs), but one has an axial-flux topology, the other one is a radial-flux outer-rotor machine and the third one is a radial-flux inner-rotor machine. Finite-element field analysis was made for the three PMSGs in order to compare their efficiency and active materials estimated cost. The results show that the axial-flux PMSG is the best solution for micro-wind turbine application.
Efficient Overproduction of Membrane Proteins in Lactococcus lactis Requires the Cell Envelope Stress Sensor/Regulator Couple CesSR

Background Membrane proteins comprise an important class of molecules whose study is largely frustrated by several intrinsic constraints, such as their hydrophobicity and added requirements for correct folding. Additionally, the complexity of the cellular mechanisms that are required to insert membrane proteins functionally in the membrane and to monitor their folding state makes it difficult to foresee the yields at which one can obtain them or to predict which would be the optimal production host for a given protein. Methods and Findings We describe a rational design approach to improve the lactic acid bacterium Lactococcus lactis as a producer of membrane proteins. Our transcriptome data shows that the two-component system CesSR, which senses cell envelope stresses of different origins, is one of the major players when L. lactis is forced to overproduce the endogenous membrane protein BcaP, a branched-chain amino acid permease. Growth of the BcaP-producing L. lactis strain and its capability to produce membrane proteins are severely hampered when the CesSR system itself or particular members of the CesSR regulon are knocked out, notably the genes ftsH, oxaA2, llmg_2163 and rmaB. Overexpressing cesSR reduced the growth defect, thus directly improving the production yield of BcaP. Applying this rationale to eukaryotic proteins, some of which are notoriously more difficult to produce, such as the medically-important presenilin complex, we were able to significantly diminish the growth defect seen in the wild-type strain and improve the production yield of the presenilin variant PS1Δ9-H6 more than 4-fold. Conclusions The results shed light into a key, and perhaps central, membrane protein quality control mechanism in L. lactis. Modulating the expression of CesSR benefited the production yields of membrane proteins from different origins. These findings reinforce L. lactis as a legitimate alternative host for the production of membrane proteins.
Enabling ICN in IP networks using SDN

In this work, we outline how to enable Information-Centric Networking (ICN) on existing IP networks, such as ISP or data center networks, using Software-Defined Networking (SDN) functions and control. We describe a mechanism that requires neither new or extended network/L3 and transport/L4 protocols nor changes of ICN host network stacks, and supports aggregation of routes inside the SDN controlled network. The proposed solution is agnostic of the specific ICN protocol in use, and does not require all network elements to be SDN-enabled. It supports advanced ICN routing features like request aggregation and forking, as well as load-balancing, traffic engineering, and explicit path steering (e. g., through ICN caches). We present the design as well as our first implementation of the proposed scheme-based on the Trema OpenFlow controller-framework and CCNx.
Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder.

CONTEXT Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent psychiatric disorder of childhood. There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed. OBJECTIVE To test the hypotheses that striatal dopamine activity is depressed in ADHD and that this contributes to symptoms of inattention. DESIGN Clinical (ADHD adult) and comparison (healthy control) subjects were scanned with positron emission tomography and raclopride labeled with carbon 11 (D2/D3 receptor radioligand sensitive to competition with endogenous dopamine) after placebo and after intravenous methylphenidate hydrochloride (stimulant that increases extracellular dopamine by blocking dopamine transporters). The difference in [11C]raclopride's specific binding between placebo and methylphenidate was used as marker of dopamine release. Symptoms were quantified using the Conners Adult ADHD Rating Scales. SETTING Outpatient setting. PARTICIPANTS Nineteen adults with ADHD who had never received medication and 24 healthy controls. RESULTS With the placebo, D2/D3 receptor availability in left caudate was lower (P < .05) in subjects with ADHD than in controls. Methylphenidate induced smaller decrements in [11C]raclopride binding in left and right caudate (blunted DA increases) (P < .05) and higher scores on self-reports of "drug liking" in ADHD than in control subjects. The blunted response to methylphenidate in caudate was associated with symptoms of inattention (P < .05) and with higher self-reports of drug liking (P < .01). Exploratory analysis using statistical parametric mapping revealed that methylphenidate also decreased [11C]raclopride binding in hippocampus and amygdala and that these decrements were smaller in subjects with ADHD (P < .001). CONCLUSIONS This study reveals depressed dopamine activity in caudate and preliminary evidence in limbic regions in adults with ADHD that was associated with inattention and with enhanced reinforcing responses to intravenous methylphenidate. This suggests that dopamine dysfunction is involved with symptoms of inattention but may also contribute to substance abuse comorbidity in ADHD.
The Prognostic Value of a Four-Dimensional CT Angiography-Based Collateral Grading Scale for Reperfusion Therapy in Acute Ischemic Stroke Patients

Objective Leptomeningeal collaterals, which affects tissue fate, are still challenging to assess. Four-dimensional CT angiography (4D CTA) originated from CT perfusion (CTP) provides the possibility of non-invasive and time-resolved assessment of leptomeningeal collateral flow. We sought to develop a comprehensive rating system to integrate the speed and extent of collateral flow on 4D CTA, and investigate its prognostic value for reperfusion therapy in acute ischemic stroke (AIS) patients. Methods We retrospectively studied 80 patients with M1 ± internal carotid artery (ICA) occlusion who had baseline CTP before intravenous thrombolysis. The velocity and extent of collaterals were evaluated by regional leptomeningeal collateral score on peak phase (rLMC-P) and temporally fused intensity projections (tMIP) (rLMC-M) on 4D CTA, respectively. The cutoffs of rLMC-P and rLMC-M score for predicting good outcome (mRS score ≤ 2) were integrated to develop the collateral grading scale (CGS) (rating from 0–2). Results The CGS score was correlated with 3-months mRS score (non-recanalizers: ρ = -0.495, p = 0.01; recanalizers: ρ = -0.671, p < 0.001). Patients with intermediate or good collaterals (CGS score of 1 and 2) who recanalized were more likely to have good outcome than those without recanalization (p = 0.038, p = 0.018), while there was no significant difference in outcome in patients with poor collaterals (CGS score of 0) stratified by recanalization (p = 0.227). Conclusions Identification of collaterals based on CGS may help to select good responders to reperfusion therapy in patients with large artery occlusion.
Angiotensin II, Independent of Plasma Renin Activity, Contributes to the Hypertension of Autonomic Failure

At least half of primary autonomic failure patients exhibit supine hypertension, despite profound impairments in sympathetic activity. Although the mechanisms underlying this hypertension are unknown, plasma renin activity is often undetectable, suggesting renin–angiotensin (Ang) pathways are not involved. However, because aldosterone levels are preserved, we tested the hypothesis that Ang II is intact and contributes to the hypertension of autonomic failure. Indeed, circulating Ang II was paradoxically increased in hypertensive autonomic failure patients (52±5 pg/mL, n=11) compared with matched healthy controls (27±4 pg/mL, n=10; P=0.002), despite similarly low renin activity (0.19±0.06 versus 0.34±0.13 ng/mL per hour, respectively; P=0.449). To determine the contribution of Ang II to supine hypertension in these patients, we administered the AT1 receptor blocker losartan (50 mg) at bedtime in a randomized, double-blind, placebo-controlled study (n=11). Losartan maximally reduced systolic blood pressure by 32±11 mm Hg at 6 hours after administration (P<0.05), decreased nocturnal urinary sodium excretion (P=0.0461), and did not worsen morning orthostatic tolerance. In contrast, there was no effect of captopril on supine blood pressure in a subset of these patients. These findings suggest that Ang II formation in autonomic failure is independent of plasma renin activity, and perhaps Ang-converting enzyme. Furthermore, these studies suggest that elevations in Ang II contribute to the hypertension of autonomic failure, and provide rationale for the use of AT1 receptor blockers for treatment of these patients.
A case study on the formation and evolution of ice supersaturation in the vicinity of a warm conveyor belt's outflow region

Abstract. A case study is presented on the formation and evolution of an ice-supersaturated region (ISSR) that was detected by a radiosonde in NE Germany at 06:00 UTC 29 November 2000. The ISSR was situated in the vicinity of the outflow region of a warm conveyor belt associated with an intense event of cyclogenesis in the eastern North Atlantic. Using ECMWF analyses and trajectory calculations it is determined when the air parcels became supersaturated and later subsaturated again. In the case considered, the state of air parcel supersaturation can last for longer than 24h. The ISSR was unusually thick: while the mean vertical extension of ISSRs in NE Germany is about 500m, the one investigated here reached 3km. The ice-supersaturated region investigated was bordered both vertically and horizontally by strongly subsaturated air. Near the path of the radiosonde the ISSR was probably cloud free, as inferred from METEOSAT infrared images. However, at other locations within the ISSR it is probable that there were cirrus clouds. Relative humidity measurements obtained by the Lindenberg radiosonde are used to correct the negative bias of the ECMWF humidity and to construct two-dimensional maps of ice supersaturation over Europe during the considered period. A systematic backward trajectory analysis for the ISSRs on these maps shows that the ISSR air masses themselves experienced only a moderate upward motion during the previous days, whereas parts of the ISSRs were located just above strongly ascending air masses from the boundary layer. This indicates qualitatively that warm conveyor belts associated with mid-latitude cyclogenesis are disturbances that can induce the formation of ISSRs in the upper troposphere. The ISSR maps also lead us to a new perception of ISSRs as large dynamic regions of supersaturated air where cirrus clouds can be embedded at some locations while there is clear air at others.
Cryptanalysis and Security Improvements of ‘Two-Factor User Authentication in Wireless Sensor Networks’

User authentication in wireless sensor networks (WSN) is a critical security issue due to their unattended and hostile deployment in the field. Since sensor nodes are equipped with limited computing power, storage, and communication modules; authenticating remote users in such resource-constrained environments is a paramount security concern. Recently, M.L. Das proposed a two-factor user authentication scheme in WSNs and claimed that his scheme is secure against different kinds of attack. However, in this paper, we show that the M.L. Das-scheme has some critical security pitfalls and cannot be recommended for real applications. We point out that in his scheme: users cannot change/update their passwords, it does not provide mutual authentication between gateway node and sensor node, and is vulnerable to gateway node bypassing attack and privileged-insider attack. To overcome the inherent security weaknesses of the M.L. Das-scheme, we propose improvements and security patches that attempt to fix the susceptibilities of his scheme. The proposed security improvements can be incorporated in the M.L. Das-scheme for achieving a more secure and robust two-factor user authentication in WSNs.
Metaphors and Emotions as Framing Strategies in Argumentation

The paper focuses on the role of both emotional and metaphorical processes in reasoning. The aim of the paper is to present an extension of the argumentative theory of reasoning proposed by Mercier and Sperber (2011). In order to advance an integrated model of the roles of metaphors and emotions in argumentation, the paper argues that it is possible to ascribe not only a negative role to emotions and metaphors, but also a positive one. Far from being just a source of fallacies in reasoning, indeed, both emotions and metaphors – considered as framing and reframing strategies – can play a constructive role in argumentation, by enhancing their creative power.
Stimulus-dependent Spiking Relationships with the Eeg. University of Pittsburgh Eye and Ear Institute Abbreviated Title: Spike-eeg Relationships

31 The development and refinement of non-invasive techniques for imaging neural activity 32 is of paramount importance for human neuroscience. Currently, the most accessible and popular 33 technique is electroencephalography (EEG). However, nearly all of what we know about the 34 neural events that underlie EEG signals is based on inference, due to a dearth of studies that 35 simultaneously paired EEG recordings with direct recordings of single neurons. From the 36 perspective of electrophysiologists there is growing interest in understanding how spiking 37 activity coordinates with large-scale cortical networks. Evidence from recordings at both scales 38 highlights that sensory neurons operate in very distinct states during spontaneous and visually 39 evoked activity, which appear to form extremes in a continuum of coordination in neural 40 networks. We hypothesized that individual neurons have idiosyncratic relationships to large41 scale network activity indexed by EEG signals, owing to the neurons’ distinct computational 42 roles within the local circuitry. We tested this by recording neuronal populations in visual area 43 V4 of rhesus macaques while we simultaneously recorded EEG. We found substantial 44 heterogeneity in the timing and strength of spike-EEG relationships, and that these relationships 45 became more diverse during visual stimulation compared to the spontaneous state. The visual 46 stimulus apparently shifts V4 neurons from a state in which they are relatively uniformly 47 embedded in large-scale network activity to a state in which their distinct roles within the local 48 population are more prominent, and suggests that the specific way in which individual neurons 49 relate to EEG signals may hold clues regarding their computational roles. 50
Dynamic Creative Interaction Networks and Team Creativity Evolution: A Longitudinal Study

To assess the dynamical effects of creative interaction networks on team creativity evolution, this paper elaborates a theoretical framework that links the key elements of creative interaction networks, including node, edge and network structure, to creativity in teams. The process of team creativity evolution is divided into four phases, including formation, growth, maturity and decline/restart. The importance of domain-relevant knowledge, creativity-relevant skill, interaction frequency, interaction length, network density and closeness centrality are emphasized in specific phases of team creativity evolution in a complex creative context. To test our assumptions, a longitudinal study of creative teams in a “Challenge Cup” Creative Business Plan Competition for university students is performed and the full networks of 17 creative entrepreneur teams are mapped. Both static comparison and dynamic analysis are conducted to analyze the relationship between creative interaction networks and team creativity evolution. For specific phases of team creativity evolution, we find confirmation of our predictions. The implications of dynamic creative interaction networks for all the phases of creative teams from formation to decline/restart are discussed.
Profiling and Purchasing Decision of Life Insurance Policies among Married Couples in Malaysia

Submitted: Mar 19, 2013; Accepted: Apr 27, 2013; Published: Jun 22, 2013 Abstract: In Malaysia, the life insurance industry has grown the strength and plays an important role in the capital market. This study examines the various socioeconomic and demographic factors associated with decisions to life insurance purchasing behaviour and total policies expenditures on life insurance by Malaysian married couples. Primary data from a survey were used in this study. The Logit model was formulated to investigate life insurance purchasing decisions and total expenditure on life insurance policy amongst married couples. Results from the empirical analysis showed income and education level of the household head supports the explanatory variables for life insurance purchasing decisions. In addition, the profile of life insurance policy purchaser is constructed to identify the segment of people and to provide good understanding on the demand for life insurance in Malaysia and would help in the formation of policies for further developing of the insurance industry.
This Paper Is Included in the Proceedings of the 12th Usenix Symposium on Operating Systems Design and Implementation (osdi '16). Netbricks: Taking the V out of Nfv Netbricks: Taking the V out of Nfv

The move from hardware middleboxes to software network functions, as advocated by NFV, has proven more challenging than expected. Developing new NFs remains a tedious process, requiring that developers repeatedly rediscover and reapply the same set of optimizations, while current techniques for providing isolation between NFs (using VMs or containers) incur high performance overheads. In this paper we describe NetBricks, a new NFV framework that tackles both these problems. For building NFs we take inspiration from modern data analytics frameworks (e.g., Spark and Dryad) and build a small set of customizable network processing elements. We also embrace type checking and safe runtimes to provide isolation in software, rather than rely on hardware isolation. NetBricks provides the same memory isolation as containers and VMs, without incurring the same performance penalties. To improve I/O efficiency, we introduce a novel technique called zero-copy software isolation.
Cancer Risk in Children and Adolescents with Birth Defects: A Population-Based Cohort Study

Objective Birth defects are an increasing health priority worldwide, and the subject of a major 2010 World Health Assembly Resolution. Excess cancer risk may be an added burden in this vulnerable group of children, but studies to date have provided inconsistent findings. This study assessed the risk for cancer in children and young adolescents with major birth defects. Methods and Findings This retrospective, statewide, population-based, cohort study was conducted in three US states (Utah, Arizona, Iowa). A cohort of 44,151 children and young adolescents (0 through 14 years of age) with selected major, non-chromosomal birth defects or chromosomal anomalies was compared to a reference cohort of 147,940 children without birth defects randomly sampled from each state’s births and frequency matched by year of birth. The primary outcome was rate of cancer prior to age 15 years, by type of cancer and type of birth defect. The incidence of cancer was increased 2.9-fold (95% CI, 2.3 to 3.7) in children with birth defects (123 cases of cancer) compared to the reference cohort; the incidence rates were 33.8 and 11.7 per 100,000 person-years, respectively. However, the excess risk varied markedly by type of birth defect. Increased risks were seen in children with microcephaly, cleft palate, and selected eye, cardiac, and renal defects. Cancer risk was not increased with many common birth defects, including hypospadias, cleft lip with or without cleft palate, or hydrocephalus. Conclusion Children with some structural, non-chromosomal birth defects, but not others, have a moderately increased risk for childhood cancer. Information on such selective risk can promote more effective clinical evaluation, counseling, and research.