Miracle-dz/UniFAR-FTUs huggingface dataset:
Chromosomal inversions and ecotypic differentiation in Anopheles gambiae: the perspective from whole‐genome sequencing

The molecular mechanisms and genetic architecture that facilitate adaptive radiation of lineages remain elusive. Polymorphic chromosomal inversions, due to their recombination‐reducing effect, are proposed instruments of ecotypic differentiation. Here, we study an ecologically diversifying lineage of Anopheles gambiae, known as the Bamako chromosomal form based on its unique complement of three chromosomal inversions, to explore the impact of these inversions on ecotypic differentiation. We used pooled and individual genome sequencing of Bamako, typical (non‐Bamako) An. gambiae and the sister species Anopheles coluzzii to investigate evolutionary relationships and genomewide patterns of nucleotide diversity and differentiation among lineages. Despite extensive shared polymorphism and limited differentiation from the other taxa, Bamako clusters apart from the other taxa, and forms a maximally supported clade in neighbour‐joining trees based on whole‐genome data (including inversions) or solely on collinear regions. Nevertheless, FST outlier analysis reveals that the majority of differentiated regions between Bamako and typical An. gambiae are located inside chromosomal inversions, consistent with their role in the ecological isolation of Bamako. Exceptionally differentiated genomic regions were enriched for genes implicated in nervous system development and signalling. Candidate genes associated with a selective sweep unique to Bamako contain substitutions not observed in sympatric samples of the other taxa, and several insecticide resistance gene alleles shared between Bamako and other taxa segregate at sharply different frequencies in these samples. Bamako represents a useful window into the initial stages of ecological and genomic differentiation from sympatric populations in this important group of malaria vectors.
EBG structures for antenna design at THz frequencies

Antennas designed in the THz band using conventional metallic waveguides have a poor performance due to the high losses of non-ideal conductors at THz frequencies. To avoid this problem, low-loss waveguides at high frequencies, e.g. ribbon waveguides or metallic wires, might be used. This paper presents the design of antennas in the THz band by means of a new rectangular waveguide. This waveguide is formed by a 1D-EBG structure on side walls, and a 3D-EBG structure, known as woodpile, on upper and lower walls. The resulting waveguide has a low attenuation in the THz band and allows the easy formation and fabrication of devices and horn antennas.
Differentiation of “Candidatus Liberibacter asiaticus” Isolates by Variable-Number Tandem-Repeat Analysis

ABSTRACT Four highly polymorphic simple sequence repeat (SSR) loci were selected and used to differentiate 84 Japanese isolates of “Candidatus Liberibacter asiaticus. ” The Nei's measure of genetic diversity values for these four SSRs ranged from 0.60 to 0.86. The four SSR loci were also highly polymorphic in four isolates from Taiwan and 12 isolates from Indonesia.
Pharmacotherapy of hyperhomocysteinaemia in patients with thrombophilia

Hyperhomocysteinaemia is often the result of inherited abnormalities of the enzymes involved in homocysteine metabolism or vitamin deficiencies (vitamins B12, B6 or folate) and is present in ∼ 5% of the general population. High homocysteine levels in these individuals are associated with a significant increase in relative risk for both arterial and venous thromboembolic disease. Consequently, effective homocysteine-lowering therapeutic strategies have been extensively investigated. Folic acid represents the cornerstone of treatment. In daily doses of at least 0.4 mg, it effectively reduces homocysteine levels, even in non-folate-deficient patients. The addition of vitamins B12 and/or B6, to folic acid supplementation may provide a small further reduction in homocysteine levels in certain groups of patients. Renal impairment is an important cause of hyperhomocysteinaemia. Individuals with hyperhomocysteinaemia secondary to renal disease commonly require significantly higher doses of folic acid (5 – 40 mg) to achieve maximal therapeutic effect. The important question of whether effective homocysteine-lowering therapy translates into a reduction in vascular disease remains unknown but is being addressed in a series of ongoing prospective trials.
Influence of moisture and low temperature on notched Izod impact toughness in a pultruded reinforced composite

A preliminary assessment was made of the influence of low temperature on the impact-generated fracture of a commercial glass-reinforced polymer composite produced by the pultrusion process. Impact tests were performed using an Izod testing machine on the composite specimens with a V-notch resulting in a fracture surface parallel to the fiber direction. Tests were conducted at 25°, -5°, -25°, and -50°C on both dry (as received) and wet (submerged for 12 hours) specimens. This paper reviews the existing data in the literature on low temperature fracture behavior of composites and compares the data obtained from these tests. Special emphasis was given to the influence of subzero temperatures on fracture behavior.
Self-reported cognitive complaints in elderly bipolar patients.

BACKGROUND Patients with bipolar disorder are at risk to develop cognitive decline in the course of their illness. This may affect their ability to monitor and detect their own cognitive functioning (anosognosia). The aim of this study was to determine whether subjective cognitive complaints were associated with objective neuropsychologic performance and to consider the role of frontal lobe dysfunction in the awareness of cognitive impairment. METHOD A total of 101 euthymic elderly bipolar patients and 74 healthy comparison subjects were assessed using a comprehensive neuropsychologic battery. The Cognitive Failure Questionnaire was used to determine subjective cognitive complaints. RESULTS Elderly bipolar patients had no more subjective cognitive complaints than comparison subjects, whereas they showed less cognitive functioning in several domains. Having few subjective cognitive complaints was associated with poorer attentional and executive functioning. CONCLUSIONS Impaired awareness of cognition might be a reflection of cognitive deterioration and could influence treatment. Evaluation of cognitive functioning in elderly bipolar patients should be part of the treatment program regardless of subjective complaints.
AdaViPro: Region-based Adaptive Visual Prompt for Large-Scale Models Adapting

Recently, prompt-based methods have emerged as a new alternative `parameter-efficient fine-tuning' paradigm, which only fine-tunes a small number of additional parameters while keeping the original model frozen. However, despite achieving notable results, existing prompt methods mainly focus on `what to add', while overlooking the equally important aspect of `where to add', typically relying on the manually crafted placement. To this end, we propose a region-based Adaptive Visual Prompt, named AdaViPro, which integrates the `where to add' optimization of the prompt into the learning process. Specifically, we reconceptualize the `where to add' optimization as a problem of regional decision-making. During inference, AdaViPro generates a regionalized mask map for the whole image, which is composed of 0 and 1, to designate whether to apply or discard the prompt in each specific area. Therefore, we employ Gumbel-Softmax sampling to enable AdaViPro's end-to-end learning through standard back-propagation. Extensive experiments demonstrate that our AdaViPro yields new efficiency and accuracy trade-offs for adapting pre-trained models.
Vitamin D analogues increase p53, p21, and apoptosis in a xenograft model of human retinoblastoma.

PURPOSE To study the antineoplastic effect of vitamin D analogues in a xenograft model of human retinoblastoma. METHODS Athymic mice were injected subcutaneously with Y79 cells and treated 5 days a week with either mineral oil (control group) or the vitamin D analogues calcitriol or 1,25-dihydroxy-16-ene-23-yne vitamin D(3) (16,23-D(3)). BrdU was injected 1 hour before death. Animals were killed after 1, 2, 3, or 5 weeks. Paraffin-embedded sections of the tumors were studied for cell proliferation by monitoring for BrdU incorporation and cell death by terminal transferase dUTP-nick end labeling (TUNEL), 3'-overhang ligation, and histology. Sections of the tumors were immunostained for p53 and p21. RESULTS There was no significant difference in incorporation of BrdU among the three groups, suggesting that cell proliferation is unaffected by vitamin D analogues. TUNEL was increased in tumors treated with vitamin D analogues compared with the control group. This increase was statistically significant for calcitriol in the time frame examined, but not statistically significant for 16,23-D(3). Alternatively, the ratio of proliferation to cell death was significantly different for both calcitriol and 16,23-D(3) compared with control tumors after 3 weeks of treatment. Dying cells contained DNA strand breaks with overhanging nucleotides and nuclear changes characteristic of apoptosis. There was an increase in staining for p53 and p21 in areas associated with cell death in specimens treated with vitamin D analogues. CONCLUSIONS Vitamin D analogues appear to attenuate retinoblastoma tumor growth in athymic mice by increasing apoptosis. Cell death is associated with the upregulation of both p53 and p21.
Interleukin-1ß and interleukin-1 receptor antagonist gene polymorphisms in rheumatoid arthritis

The purpose of this study was to evaluate if IL-1β (IL-1β promoter and IL-1β exon 5) and IL-1 receptor antagonist (IL-1Ra) gene polymorphisms act as markers of susceptibility to or severity of RA. The study included 104 RA patients and 103 normal controls. No significant difference was observed in the cytokine allelic frequencies of IL-1β promoter and IL-1β exon 5 between patients with RA and healthy controls. In addition, there was no significant association in the cytokine carriage rates of I and II allele of IL-1Ra between RA patients and healthy controls. In contrast, the IV allele of IL-1Ra was significantly increased in RA patients with low inflammatory activity (P = 0.03). This study indicated that allelic frequency and carriage rate of IL-1β (IL-1β promoter and IL-1β exon 5) and IL-1Ra (I and II allele) do not differ significantly between normal controls and RA patients in Taiwan. However, the carriage rate of IV allele of IL-1Ra was high in the RA patients with low inflammatory activity.
The Psychology of Corporate Social Responsibility and Humanitarian Work: A Person-Centric Perspective

The field of industrial–organizational (I–O) psychology has and will continue to experience periods of growth and change. Our field has shifted and transformed along with society, through the industrial revolution, the human relations movement, the globalization of business, and the information age. And here we are, in 2013, at the cusp of what seems to be the beginning of a new stage in our development, this time evidenced by the marked attention that both the science and practice arms of I–O psychology are placing on issues of corporate social responsibility (CSR, Aguinis, 2011; Cruse, 2010; Scott et al. 2013)
Correspondence Between Health Attitudes and Behavior

College students completed a questionnaire that assessed general beliefs and attitudes with respect to matters of health and illness, as well as specific beliefs and attitudes concerning each of 24 health-related behaviors selected in a pilot study. In addition, the frequencies with which each of the 24 behaviors were reportedly performed were used as single-act criteria and to construct an aggregate measure of health behavior (multiple-act criterion). Consistent with previous work on the attitude-behavior relation, predictability of health behavior was contingent on measurement correspondence. Specific health behaviors were largely unrelated to general attitudes toward medical services, concern about illness, evaluations of health practices, or health locus of control; but they did correlate quite well with equally specific attitudes toward, and perceived control over, each behavior. Also consistent with the principle of correspondence, attitudes toward performing recommended health practices in general .
Auto-tuning Spark big data workloads on POWER8: Prediction-based dynamic SMT threading

Much research work devotes to tuning big data analytics in modern data centers, since even a small percentage of performance improvement immediately translates to huge cost savings because of the large scale. Simultaneous multithreading (SMT) receives great interest from data center communities, as it has the potential to boost performance of big data analytics by increasing the processor resources utilization. For example, the emerging processor architectures like POWER8 support up to 8-way multithreading. However, as different big data workloads have disparate architectural characteristics, how to identify the most efficient SMT configuration to achieve the best performance is challenging in terms of both complex application behaviors and processor architectures. In this paper, we specifically focus on auto-tuning SMT configuration for Spark-based big data workloads on POWER8. However, our methodology could be generalized and extended to other programming software stacks and other architectures. We propose a prediction-based dynamic SMT threading (PBDST) framework to adjust the thread count in SMT cores on POWER8 processors by using versatile machine learning algorithms. Its innovation lies in adopting online SMT configuration predictions derived from microarchitecture level profiling, to regulate the thread counts that could achieve nearly optimal performance. Moreover it is implemented at Spark software stack layer and transparent to user applications. After evaluating a large set of machine learning algorithms, we choose the most efficient ones to perform online predictions. The experimental results demonstrate that our approach can achieve up to 56.3% performance improvement and an average performance gain of 16.2% in comparison with the default configuration-the maximum SMT configuration-SMT8 on our system.
Perceived Changes in Personal Circumstances Related to Social Change: Associations with Psychosocial Resources and Depressive Symptoms

Social change is a ubiquitous phenomenon comprising tendencies such as globalization, demographic change, and pluralization of biographical trajectories. Based on stress theories and related challenge-response models, the present study investigated whether depressive symptoms were related to an accumulation of perceived demands associated with social change in a sample of 2,522 German adolescents and adults. In addition, buffering effects of personal and social resources on the association between perceived demands and depressive symptoms were tested. By means of structural equation modeling, we found that accumulations of work-, family-, and public life-related demands were associated with higher levels of depressive symptoms, even after controlling for demographic and other confounding variables. Optimism and social support were found to be associated with lower depressive symptoms. Furthermore, both optimism and social support reduced the size of associations between demands of social change and depressive symptoms. Overall, these results underscore the association of social change and psychosocial resources with individuals' depressive symptoms.
Maximal ideals of reduced group C*-algebras and Thompson's groups

Given a conditional expectation $P$ from a C*-algebra $B$ onto a C*-subalgebra $A$, we observe that induction of ideals via $P$, together with a map which we call co-induction, forms a Galois connection between the lattices of ideals of $A$ and $B$. Using properties of this Galois connection, we show that, given a discrete group $G$ and a stabilizer subgroup $G_x$ for the action of $G$ on its Furstenberg boundary, induction gives a bijection between the set of maximal co-induced ideals of $C^*(G_x)$ and the set of maximal ideals of $C^*_r(G)$. As an application, we prove that the reduced C*-algebra of Thompson's group $T$ has a unique maximal ideal. Furthermore, we show that, if Thompson's group $F$ is amenable, then $C^*_r(T)$ has infinitely many ideals.
A critical assessment of high-resolution aerosol optical depth retrievals for fine particulate matter predictions

Abstract. Recently, a new Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm was developed for the MODerate Resolution Imaging Spectroradiometer (MODIS), which provides aerosol optical depth (AOD) at 1 km resolution. The relationship between MAIAC AOD and PM2.5 as measured by 84 EPA ground monitoring stations in the entire New England and the Harvard super site during 2002–2008 was investigated and also compared to the AOD–PM2.5 relationship using conventional MODIS 10 km AOD retrieval from Aqua platform (MYD04) for the same days and locations. The correlations for MYD04 and for MAIAC are r = 0.62 and 0.65, respectively, suggesting that AOD is a reasonable proxy for PM2.5 ground concentrations. The slightly higher correlation coefficient (r) for MAIAC can be related to its finer resolution resulting in better correspondence between AOD and EPA monitoring sites. Regardless of resolution, AOD–PM2.5 relationship varies daily, and under certain conditions it can be negative (due to several factors such as an EPA site location (proximity to road) and the lack of information about the aerosol vertical profile). By investigating MAIAC AOD data, we found a substantial increase, by 50–70% in the number of collocated AOD–PM2.5 pairs, as compared to MYD04, suggesting that MAIAC AOD data are more capable in capturing spatial patterns of PM2.5. Importantly, the performance of MAIAC AOD retrievals is slightly degraded but remains reliable under partly cloudy conditions when MYD04 data are not available, and it can be used to increase significantly the number of days for PM2.5 spatial pattern prediction based on satellite observations.
Direct Inoculation of Simian Immunodeficiency Virus from Sooty Mangabeys in Black Mangabeys (Lophocebus aterrimus): First Evidence of AIDS in a Heterologous African Species and Different Pathologic Outcomes of Experimental Infection

ABSTRACT A unique opportunity for the study of the role of serial passage and cross-species transmission was offered by a series of experiments carried out at the Tulane National Primate Research Center in 1990. To develop an animal model for leprosy, three black mangabeys (BkMs) (Lophocebus aterrimus) were inoculated with lepromatous tissue that had been serially passaged in four sooty mangabeys (SMs) (Cercocebus atys). All three BkMs became infected with simian immunodeficiency virus from SMs (SIVsm) by day 30 postinoculation (p.i.) with lepromatous tissue. One (BkMG140) died 2 years p.i. from causes unrelated to SIV, one (BkMG139) survived for 10 years, whereas the third (BkMG138) was euthanized with AIDS after 5 years. Histopathology revealed a high number of giant cells in tissues from BkMG138, but no SIV-related lesions were found in the remaining two BkMs. Four-color immunofluorescence revealed high levels of SIVsm associated with both giant cells and T lymphocytes in BkMG138 and no detectable SIV in the remaining two. Serum viral load (VL) showed a significant increase (>1 log) during the late stage of the disease in BkMG138, as opposed to a continuous decline in VL in the remaining two BkMs. With the progression to AIDS, neopterin levels increased in BkMG138. This study took on new significance when phylogenetic analysis unexpectedly showed that all four serially inoculated SMs were infected with different SIVsm lineages prior to the beginning of the experiment. Furthermore, the strain infecting the BkMs originated from the last SM in the series. Therefore, the virus infecting BkMs has not been serially passaged. In conclusion, we present the first compelling evidence that direct cross-species transmission of SIV may induce AIDS in heterologous African nonhuman primate (NHP) species. The results showed that cross-species-transmitted SIVsm was well controlled in two of three BkMs for 2 and 10 years, respectively. Finally, this case of AIDS in an African monkey suggests that the dogma of SIV nonpathogenicity in African NHP hosts should be reconsidered.
Intensity-Modulated Radiation Therapy Without Concurrent Chemotherapy for Stage IIB Nasopharyngeal Cancer

Objectives:To evaluate the treatment outcome of patients with stage IIB nasopharyngeal carcinoma (NPC) after definitive intensity-modulated radiotherapy (IMRT) without concurrent chemotherapy. Methods:Between August 2003 and December 2006, 107 patients with T1N1M0 (8%), T2N0M0 (13%), or T2N1M0 (79%) NPC were definitively treated with IMRT. Sixty-one received IMRT only, and 46 patients had various strategies of systemic treatment, consisting of abbreviated neoadjuvant (38 patients), concurrent (8 patients), or adjuvant (16 patients) chemotherapy. Radiation doses prescribed to the planning tumor volume of the gross disease, high-risk clinical tumor volume, and low-risk clinical tumor volume were 66 to 70 Gy, 54 to 60 Gy, and 50–54 Gy, respectively. Results:With a median follow-up of 39 months (range, 7–77 months), 6 patients had locoregional relapse: 1 local only, 1 locoregional, and 4 regional only. Five patients had distant failure. Five of 6 total deaths were cancer related. The 3-year estimated local control, regional control, metastasis-free survival, disease-free survival, and overall survival were 96.5%, 98%, 94.8%, 90.7%, and 95.8%, respectively. No significant difference in treatment outcome was demonstrated in patients treated with or without chemotherapy of any schedule. Conclusions:IMRT without concurrent chemotherapy provides good outcome for patients with stage IIB NPC with acceptable toxicity. Neoadjuvant chemotherapy did not appear to provide significant additional benefit for this patient subgroup. Further investigation in the prospective setting is warranted to explore the role of systemic agents in the treatment of NPC with limited primary disease and cervical lymphadenopathy when IMRT is used.