Miracle-dz/UniFAR-FTUs huggingface dataset:
Five years of land surface phenology in a large-scale flooding and draining manipulation in a coastal Arctic ecosystem

This study was motivated by the knowledge gap for observing the complex interplay between surface hydrology and plant phenology in arctic landscapes and was conducted as part of a large scale, multi investigator flooding and draining experiment near Barrow, Alaska (71°17’01” N, 156°35’48” W) during 2005 - 2009. Hyperspectral reflectance data were collected in the visible to near IR region of the spectrum using a robotic tram system that operated along a 300m transects during the snow free growing period between June and August, 2005-09. Interannual patterns of land-surface phenology (NDVI) unexpectedly lacked marked differences under experimental conditions. Measurement of NDVI was, however, compromised for presence of surface water. Land-surface phenology and surface water was negatively correlated, which held when scaled to a 2km by 2km MODIS subset of the study area. This result suggested that published findings of ‘greening of the Arctic’ may relate to a ‘drying of the Arctic’ i.e. reduced surface water in vegetated high-latitude landscapes where surface water is close to ground level.
StellaTUM: current consensus and discussion on pancreatic stellate cell research

The field of pancreatic stellate cell (PSC) biology is very young, as the essential in-vitro tools to study these cells (ie, methods to isolate and culture PSC) were only developed as recently as in 1998. Nonetheless, there has been an exponential increase in research output in this field over the past decade, with numerous research groups around the world focusing their energies into elucidating the biology and function of these cells. It is now well established that PSC are responsible for producing the stromal reaction (fibrosis) of two major diseases of the pancreas—chronic pancreatitis and pancreatic cancer. Despite exponentially increasing data, the methods for studying PSC remain variable. Although within individual laboratories methods are consistent, different methodologies used by various research groups make it difficult to compare results and conclusions. This article is not a review article on the functions of PSC. Instead, members of the Pancreatic Star Alliance (http://www.pancreaticstaralliance.com) discuss here and consolidate current knowledge, to outline and delineate areas of consensus or otherwise (eg, with regard to methodological approaches) and, more importantly, to identify essential directions for future research. Hepatic stellate cells (HSC) were first described by Karl von Kupffer in 1876; however, similar cells in the pancreas were first observed in the 1980s.1–3 In 1998, Apte et al 4 and Bachem et al 5 isolated and cultured PSC.4 5 In the normal pancreas, PSC are located in close proximity to the basal aspect of pancreatic acinar cells. In sections immunostained for the marker desmin (a cytoskeletal protein), quiescent PSC can be seen as cells with a central cell body and long cytoplasmic projections extending along the base of adjacent acinar cells similar to that of pericytes in the mammary gland. …
THE FACTORIAL STRUCTURE OF THE ARABIC VERSION OF THE REVISED COLLETT–LESTER FEAR OF DEATH SCALE

A sample of 209 volunteer Kuwaiti undergraduates responded to an Arabic version of the Revised Collett–Lester Fear of Death Scale with 4 subscales: Death of Self, Dying of Self, Death of Others, and Dying of Others. Reliabilities of the 4 subscales and of the grand total score ranged from 0.75 to 0.92, which is considered adequate. A 4-factor solution was congruent with the allocation of items to 2 subscales (i.e. Dying of Self and Death of Others), whereas the theorized factor structure of the other 2 subscales were only partially supported by empirical analyses. The intercorrelations between the 4 total subscale scores yielded a general factor of death and dying, denoting good factorial validity of the scale.
Association of Common Variants in MMPs with Periodontitis Risk

Background. Matrix metalloproteinases (MMPs) are considered to play an important role during tissue remodeling and extracellular matrix degradation. And functional polymorphisms in MMPs genes have been reported to be associated with the increased risk of periodontitis. Recently, many studies have investigated the association between MMPs polymorphisms and periodontitis risk. However, the results remain inconclusive. In order to quantify the influence of MMPs polymorphisms on the susceptibility to periodontitis, we performed a meta-analysis and systematic review. Results. Overall, this comprehensive meta-analysis included a total of 17 related studies, including 2399 cases and 2002 healthy control subjects. Our results revealed that although studies of the association between MMP-8 −799 C/T variant and the susceptibility to periodontitis have not yielded consistent results, MMP-1 (−1607 1G/2G, −519 A/G, and −422 A/T), MMP-2 (−1575 G/A, −1306 C/T, −790 T/G, and −735 C/T), MMP-3 (−1171 5A/6A), MMP-8 (−381 A/G and +17 C/G), MMP-9 (−1562 C/T and +279 R/Q), and MMP-12 (−357 Asn/Ser), as well as MMP-13 (−77 A/G, 11A/12A) SNPs are not related to periodontitis risk. Conclusions. No association of these common MMPs variants with the susceptibility to periodontitis was found; however, further larger-scale and multiethnic genetic studies on this topic are expected to be conducted to validate our results.
ENHANCED ULTRAWIDEBAND (UWB) MICRO-STRIP ON-BODY WEARABLE ANTENNA

This paper presents an ultra-wideband micro-strip patch On-Body wearable antenna for medical applications using WiMAX. The antenna uses thick indigo blue jeans as substrate. The antenna is designed at the resonant frequency of 3.5 GHz. The dimensions of the antenna and the slit have been modified to achieve wide bandwidth. By doing so, not only the bandwidth of 15 GHz has been achieved but the antenna size is reduced by 13.4% as well. The proposed antenna simulation results including gain, directivity and radiation pattern are reported. The results show that the antenna not only provides satisfactory results for the WiMAX applications but also provides extremely good results including the VSWR of 1.12, the gain of 5.8 dB and the directivity of 6.8 dB at 20 GHz. The proposed antenna achieves a remarkable bandwidth improvement as well as a significant reduction in antenna size. Hence, the proposed antenna can be used for medical applications using WiMAX as well as the applications operating up to at 20 GHz.
Genetic regulation of fructosyltransferase in Streptococcus mutans

Streptococcus mutans possesses several extracellular sucrose-metabolizing enzymes which have been implicated as important virulence factors in dental caries. This study was initiated to investigate the genetic regulation of one of these enzymes, the extracellular fructosyltransferase (Ftf). Fusions were constructed with the region upstream of the S. mutans GS5 Ftf gene (ftf) and a promoterless chloramphenicol acetyltransferase (CAT) gene. The fusions were integrated at a remote site in the chromosome, and transcriptional activity in response to the addition of various carbohydrates to the growth medium was measured. A significant increase in CAT activity was observed when glucose-grown cells were shifted to sucrose-containing medium. Sucrose-induced expression was repressed immediately upon addition of phosphoenolpyruvate phosphotransferase system sugars to the growth media. Deletion analysis of the ftf upstream region revealed that an inverted repeat structure was involved in the control of ftf expression in response to carbohydrate. However, the control of the level of ftf transcription appeared to involve a region distinct from that mediating carbohydrate regulation. CAT gene fusions also were constructed with the ftf upstream region from S. mutans V403, a fructan-hyperproducing strain which synthesizes increased levels of Ftf. Sequence analysis of the upstream ftf region in this strain revealed several nucleotide sequence changes which were associated with high-level ftf expression. Comparison of the GS5 and V403 ftf expression patterns suggested the presence of a trans-acting factor(s) involved in modulation of ftf expression in response to carbohydrate. This factor(s) was either absent or altered in V403, resulting in the inability of this organism to respond to the presence of carbohydrate. The sequences of the ftf regions from three additional fructan-hyperproducing strains were determined and compared with that of V403. Only one strain displayed nucleotide changes similar to those of V403. Two additional strains did not have these changes, suggesting that several mechanisms for up-regulation of ftf expression exist.
How Does Subclinical Hyperthyroidism Affect Right Heart Function and Mechanics?

Right heart function and mechanics have not been investigated in patients with subclinical hyperthyroidism. Our aim was to investigate right ventricular (RV) and right atrial (RA) function and deformation as evaluated by 3‐dimensional echocardiography (3DE) and speckle‐tracking 2‐dimensional echocardiography (2DE) in these individuals.
Selective heart rate variability analysis to account for uterine activity during labor and improve classification of fetal distress

Cardiotocography (CTG) is currently the most often used technique for detection of fetal distress. Unfortunately, CTG has a poor specificity. Recent studies suggest that, in addition to CTG, information on fetal distress can be obtained from analysis of fetal heart rate variability (HRV). However, uterine contractions can strongly influence fetal HRV. The aim of this study is therefore to investigate whether HRV analysis for detection of fetal distress can be improved by distinguishing contractions from rest periods. Our results from feature selection indicate that HRV features calculated separately during contractions or during rest periods are more informative on fetal distress than HRV features that are calculated over the entire fetal heart rate. Furthermore, classification performance improved from a geometric mean of 69.0% to 79.6% when including the contraction-dependent HRV features, in addition to HRV features calculated over the entire fetal heart rate.
Risky Behavior in Gambling Tasks in Individuals with ADHD – A Systematic Literature Review

Objective The aim of this review was to gain insight into the relationship between Attention deficit hyperactivity disorder (ADHD) and risky performance in gambling tasks and to identify any potential alternate explanatory factors. Methods PsycINFO, PubMed, and Web of Knowledge were searched for relevant literature comparing individuals with ADHD to normal controls (NCs) in relation to their risky performance on a gambling task. In total, fourteen studies in children/adolescents and eleven studies in adults were included in the review. Results Half of the studies looking at children/adolescents with ADHD found evidence that they run more risks on gambling tasks when compared to NCs. Only a minority of the studies on adults with ADHD reported aberrant risky behavior. The effect sizes ranged from small to large for both age groups and the outcome pattern did not differ between studies that applied an implicit or explicit gambling task. Two studies demonstrated that comorbid oppositional defiant disorder (ODD) and conduct disorder (CD) increased risky behavior in ADHD. Limited and/or inconsistent evidence was found that comorbid internalizing disorders (IDs), ADHD subtype, methylphenidate use, and different forms of reward influenced the outcomes. Conclusion The evidence for increased risky performance of individuals with ADHD on gambling tasks is mixed, but is stronger for children/adolescents with ADHD than for adults with ADHD, which may point to developmental changes in reward and/or penalty sensitivity or a publication bias for positive findings in children/adolescents. The literature suggests that comorbid ODD/CD is a risk factor in ADHD for increased risky behavior. Comorbid IDs, ADHD subtype, methylphenidate use, and the form of reward received may affect risky performance in gambling tasks; however, these factors need further examination. Finally, the implications of the findings for ADHD models and the ecological validity of gambling tasks are discussed.
Comparison of ciprofloxacin and ceftriaxone as single-dose therapy for uncomplicated gonorrhea in women

Although women bear the brunt of gonococcal infection-related morbidity, few large studies of gonorrhea treatment in women have been conducted. In a multicenter, double-blind, placebo-controlled trial, 181 evaluable women with uncomplicated gonorrhea were treated with ciprofloxacin (250 mg orally; 94 women) or ceftriaxone (250 mg intramuscularly; 87 women). Twenty-four percent of the participants were infected with antibiotic-resistant Neisseria gonorrhoeae. Cervical gonorrhea was cured in 100% (93 of 93) of the women treated with ciprofloxacin and 99% (83 of 84) receiving ceftriaxone. All pharyngeal (n = 5) or rectal (n = 20) infections treated with ciprofloxacin were cured, as were ceftriaxone-treated patients with pharyngeal (n = 6) or rectal (n = 21) infection. Geometric mean MICs (range) for 248 pretreatment isolates were: penicillin, 0.28 (0.015 to 8.0); tetracycline, 0.46 (0.06 to 4); ciprofloxacin, 0.003 (0.002 to 0.015); and ceftriaxone, 0.004 (0.001 to 0.125) microgram/ml. Both drugs were well tolerated. Despite the high prevalence of antibiotic-resistant gonococci in these populations, 250 mg of oral ciprofloxacin was as effective as an injection of ceftriaxone.
Unconscious Physiological Effects of Search Latency on Users and Their Click Behaviour

Understanding the impact of a search system's response latency on its users' searching behaviour has been recently an active research topic in the information retrieval and human-computer interaction areas. Along the same line, this paper focuses on the user impact of search latency and makes the following two contributions. First, through a controlled experiment, we reveal the physiological effects of response latency on users and show that these effects are present even at small increases in response latency. We compare these effects with the information gathered from self-reports and show that they capture the nuanced attentional and emotional reactions to latency much better. Second, we carry out a large-scale analysis using a web search query log obtained from Yahoo to understand the change in the way users engage with a web search engine under varying levels of increasing response latency. In particular, we analyse the change in the click behaviour of users when they are subject to increasing response latency and reveal significant behavioural differences.
Data-driven hallucination of different times of day from a single outdoor photo

We introduce "time hallucination": synthesizing a plausible image at a different time of day from an input image. This challenging task often requires dramatically altering the color appearance of the picture. In this paper, we introduce the first data-driven approach to automatically creating a plausible-looking photo that appears as though it were taken at a different time of day. The time of day is specified by a semantic time label, such as "night". Our approach relies on a database of time-lapse videos of various scenes. These videos provide rich information about the variations in color appearance of a scene throughout the day. Our method transfers the color appearance from videos with a similar scene as the input photo. We propose a locally affine model learned from the video for the transfer, allowing our model to synthesize new color data while retaining image details. We show that this model can hallucinate a wide range of different times of day. The model generates a large sparse linear system, which can be solved by off-the-shelf solvers. We validate our methods by synthesizing transforming photos of various outdoor scenes to four times of interest: daytime, the golden hour, the blue hour, and nighttime.
MICROBIAL ARSENIC CYCLING IN ITALIAN RICE PADDIES: AN ECOLOGICAL PERSPECTIVE

Rice is characterized by high levels of arsenic accumulation, even if cultivated in non-contaminated soils. Given the limits for arsenic concentration in rice grain recently established by the European Community, it is essential to understand the mechanisms and find solutions to this issue. Arsenic bioavailability is strictly related to water management of the rice paddy as well as to ironand arseniccycling bacterial populations inhabiting the rice rhizosphere. To evaluate the effect of different agronomic conditions on the root-soil microbiota involved in arsenic mobilization, rice plants were grown in macrocosms containing non-contaminated field soil under either continuous flooding, aerobic rice regime or continuous flooding with a 14 day-period of drainage before flowering. Specific groups of ironand arsenic-cycling bacteria were assessed by real time quantitative PCR and fluorescence in situ hybridization. Continuous flooding led to the release of arsenate and iron in soil solution and produced rice grains with arsenite and organic arsenic above the recently established limits, contrary to the other agronomic conditions. 7 Iron-reducing bacteria affiliated to the family Geobacteraceae significantly increased under continuous flooding in rhizosphere soil, in concomitance to arsenate dissolution from iron minerals. The 14 day-period of drainage before flowering allowed the recycling of iron, with the increase of Gallionella-like iron-oxidizing bacteria. This phenomenon likely influenced the decrease of arsenic translocation in rice grains. Regardless of the water regime, genes for arsenite oxidation (aioA) were the most abundant arsenicprocessing genes, explaining the presence of arsenate in soil solution. The presence of arsenite and organic arsenic in rice grains produced under continuous flooding might be related to the retrieval of genes for arsenate reduction (arsC) and for arsenite methylation (arsM) in the proximity of the roots. These outcomes indicate a potential active role of rhizospheric ironand arsenic-cycling bacteria in determining arsenic accumulation in rice grains from plants cultivated under continuous flooding, even in soil with a low arsenic content.
Antagonistic forces generated by myosin II and cytoplasmic dynein regulate microtubule turnover, movement, and organization in interphase cells

Photoactivation of caged fluorescent tubulin was used mark the microtubule (MT) lattice and monitor MT behavior in interphase cells. A broadening of the photoactivated region occurred as MTs moved bidirectionally. MT movement was not inhibited when MT assembly was suppressed with nocodazole or Taxol; MT movement was suppressed by inhibition of myosin light chain kinase with ML7 or by a peptide inhibitor. Conversely, MT movement was increased after inhibition of cytoplasmic dynein with the antibody 70.1. In addition, the half-time for MT turnover was decreased in cells treated with ML7. These results demonstrate that myosin II and cytoplasmic dynein contribute to a balance of forces that regulates MT organization, movement, and turnover in interphase cells.
Cholera toxin: A paradigm of a multifunctional protein

Cholera toxin (CT) was discovered exactly half a century ago by S.N. De. We have come a long way since this epoch-making discovery. Retrospectively, science had to wait a long time since Koch’s prediction of the existence of a toxin, and its actual discovery by De. CT is not just another enterotoxin that causes the signs and symptoms of the dreaded disease, cholera. It is unique in many respects, starting from its structure to its functions. CT is a multifunctional protein that is capable of influencing the immune system in many ways. It not only has remarkable adjuvant properties, but also acts as an anti-inflammatory agent, by modulating specific signal transduction pathways. Its immunomodulatory properties can be harnessed for treatment of various autoimmune disorders, and have shown great promise in the area of immunotherapeutics. CT can truly be considered as a paradigm of a multifunctional protein.
Factors Influencing the Dosimetry for High-Intensity Focused Ultrasound Ablation of Uterine Fibroids

AbstractThe aim of this article is to analyze factors affecting sonication dose and build a dosimetry model of high-intensity focused ultrasound (HIFU) ablation for uterine fibroids.Four hundred and three patients with symptomatic uterine fibroids who underwent HIFU were retrospectively analyzed. The energy efficiency factor (EEF) was set as dependent variable, and the factors possibly affecting sonication dose included age, body mass index, size of uterine fibroid, abdominal wall thickness, the distance from uterine fibroid dorsal side to sacrum, the distance from uterine fibroid ventral side to skin, location of uterus, location of uterine fibroids, type of uterine fibroids, abdominal wall scar, signal intensity on T2-weighted imaging (T2WI), and enhancement type on T1-weighted imaging (T1WI) were set as predictors to build a multiple regression model.The size of uterine fibroid, distance from fibroid ventral side to skin, location of uterus, location of uterine fibroids, type of uterine fibroids, signal intensity on T2WI, and enhancement type on T1WI had a linear correlation with EEF. The distance from fibroid ventral side to skin, enhancement type on T1WI, size of uterine fibroid, and signal intensity on T2WI were eventually incorporated into the dosimetry model.The distance from fibroid ventral side to skin, enhancement type on T1WI, size of uterine fibroid, and signal intensity on T2WI can be used as dosimetric predictors for HIFU for uterine fibroids.
Clinical Characteristics of Cutaneous Melanoma and Second Primary Malignancies in a Dutch Hospital-Based Cohort of Cutaneous Melanoma Patients

The increasing number of living cutaneous melanoma patients and the increased risk of developing a second primary tumour incited us to analyse the clinical characteristics of cutaneous melanoma and define the frequency, site, and type of second primary cancers in cutaneous melanoma patients. We collected data on patients who visited the Department of Dermatology at the Radboud University Nijmegen Medical Centre and were newly diagnosed with cutaneous melanoma or metastasis of melanoma with unknown primary localization between 2002 and 2006. A total of 194 cases were included; eleven patients developed a subsequent melanoma, 24 had at least one basal cell carcinoma, three had at least one squamous cell carcinoma, and 21 patients had a second non-cutaneous primary malignancy. In conclusion, 48 patients developed a subsequent malignancy. As nonmelanoma skin cancer is the most frequent second malignancy, our results subscribe to the necessity of follow-up by a dermatologist.
Cultural heritage in project management: project appraisal and quality assurance in the early phase of major public investments

Abstract This paper is an analysis of how cultural heritage values are handled in documentation related to early phase evaluations of major public investment projects in Norway. This study was instigated by an apparent lack in the consideration of cultural heritage values in such documentation. We conducted a case study document analysis to see how cultural heritage issues are addressed in the early phases of projects. Methodologically, the paper analyses the use of vocabulary related to cultural heritage values in the documentation. There is uniform documentation available from these projects. The results suggest that cultural heritage values are mentioned but seldom substantially discussed in the documents. Cultural heritage values tend to be discussed using non-specific language. There is an emphasis on legislation regarding cultural heritage and how the legislation can be a problem. Today’s discussion of cultural heritage values appears to be lacking and in need of a strengthened framework. The methodology applied in this study aims to provide a structured search method for the unstructured discussion of cultural heritage issues in these extensive documents.