Miracle-dz/UniFAR-FTUs huggingface dataset:
Temporal contrast sensitivity in the lateral geniculate nucleus of a New World monkey, the marmoset Callithrix jacchus

1 The temporal contrast sensitivity of koniocellular, parvocellular and magnocellular cells in the lateral geniculate nucleus (LGN) of nine adult marmosets was measured. The receptive fields of the cells were between 0.3 and 70 deg from the fovea. The stimulus was a large spatially uniform field which was modulated in luminance at temporal frequencies between 0.98 and 64 Hz. 2 For each cell group there was a gradual increase in modulation sensitivity, especially for temporal frequencies below 8 Hz, with increasing distance from the fovea. At any given eccentricity, magnocellular cells had the greatest sensitivity. In central visual field, the sensitivity of koniocellular cells lay between that of parvocellular and magnocellular cells. In peripheral visual field (above 10 deg eccentricity) koniocellular and parvocellular cells had similar sensitivity. 3 The contrast sensitivity of each cell class was dependent on the anaesthetic used. Cells from animals anaesthetized with isoflurane were less sensitive than cells from animals anaesthetized with sufentanil. This effect was more marked for temporal frequencies below 4 Hz. 4 These results are incompatible with the notion that the koniocellular pathway is functionally homologous to a sluggish, W‐like pathway in other mammals. At least in terms of their temporal transfer properties, many koniocellular cells are more like parvocellular cells.
Clinicopathological Features and Surgical Treatment of Gastric Cancer in South Korea: The Results of 2009 Nationwide Survey on Surgically Treated Gastric Cancer Patients

Purpose In an effort to examine the clinicopathological characteristics of GC and the status of its surgical treatment, the Korean Gastric Cancer Association (KGCA) conducted a nationwide survey targeting surgically-treated gastric cancer patients in 2009. Materials and Methods A standardized electrical case report was sent to every member institution of the KGCA via E-mail with detailed instructions regarding the survey data. Completed data forms were retrieved from each institution and analyzed by the KGCA information committee. Results Data on 14,658 patients was collected from 59 institutions. The mean patient age was 59.2±11.9 years with a male to female ratio of 2.05 : 1. Lower third cancer (56.0%) was the most common among all gastric cancers. The histological type revealed poorly differentiated adenocarcinoma (34.1%) to be the most common, and the Lauren classification revealed the intestinal type (50.0%) to be the most prevalent. Curative surgery was performed in 92.4% of patients with laparoscopic surgery in 25.8% of patients. A Billroth I reconstruction was performed most frequently after a distal gastrectomy (63.4% of distal gastrectomy). T1 cancers accounted for 57.6% of all cases, and 62.6% of patients showed no lymph node metastasis. Compared to previous reports, it was found that patients are becoming older, laparoscopic surgery is being performed increasingly, and the proportion of T1 cancer is increasing with time. Conclusions This survey presented the clinicopathological characteristics and current status of the surgical treatment of gastric cancer in Korea. This survey is expected aid research studies as well as planning and evaluation programs targeting cancer control.
Analysis and comparative study of ferrofluid lubricated circular porous squeeze film-bearings

Based on ferrohydrodynamic theory by R. E. Rosensweig and continuity equation for film as well as upper and lower porous regions, a general modified Reynolds equation for ferrofluid (FF) lubricated circular discs porous squeeze film-bearings is derived by assuming the validity of the Darcy’s law in the porous regions. The effects of porosity, slip velocity, anisotropic permeability and rotation at both the discs are also included for the study. Here, the FF is controlled by oblique and radially variable magnetic field. The effect of porosity is included because of its advantageous property of self-lubrication, and oblique variable magnetic field is important because of its advantage of generating maximum field at the required active contact zone of the bearing design systems. Using Reynolds equation, different circular porous squeeze film-bearing design systems (e.g. exponential, secant and parallel (flat)) are studied and compared for load-carrying capacity. During the course of investigation, it is observed that uniform magnetic field does not affect on the performances of the bearing systems.
A Meta-Analysis of Maternal Smoking during Pregnancy and Autism Spectrum Disorder Risk in Offspring

The association between maternal smoking during pregnancy and autism spectrum disorder (ASD) risk in offspring has been investigated in several studies, but the evidence is not conclusive. We, therefore, conducted this meta-analysis to explore whether an association exists between maternal smoking during pregnancy and ASD risk in offspring. We searched PubMed, Embase, Web of Science, and the Cochrane Library for studies of maternal smoking during pregnancy and ASD risk in offspring up to 10 June 2015. The random-effects model was used to combine results from individual studies. 15 observational studies (6 cohort studies and 9 case-control studies), with 17,890 ASD cases and 1,810,258 participants were included for analysis. The pooled odds ratio (OR) was 1.02 (95% confidence interval (CI): 0.93–1.13) comparing mothers who smoked during pregnancy with those who did not. Subgroup and sensitivity analysis suggested the overall result of this analysis was robust. Results from this meta-analysis indicate that maternal smoking during pregnancy is not associated with ASD risk in offspring. Further well-designed cohort studies are needed to confirm the present findings.
SQLUnitGen: SQL Injection Testing Using Static and Dynamic Analysis

This paper proposes an approach to facilitate the identification of actual input manipulation vulnerabilities via automated testing based on static analysis. We implemented a prototype of a SQL injection vulnerability detection tool, SQLUnitGen, which we compared to a static analysis tool, FindBugs. The evaluation results show that our approach can be used to locate precise vulnerable locations of source code and help to identify false positives that are caused by static analysis tools.
A methodological approach to ratio bias

The ratio-bias (RB) phenomenon is considered to provide systematic evidence of irrationality. When judging the probability of a low-probability event, many people judge it as less likely when it is expressed as a ratio of small numbers (e.g., 1-in-10) than when it is expressed as a ratio of large numbers (e.g., 10-in-100). Four experiments show that the phenomenon is increased by the experimental paradigm, which misleads subjects regarding the aim of the task by inducing equal-ratio neglect. One factor is constant across the texts of the Experiment 1–3: a particular sentence that induces subjects to neglect the equal ratio and invites them to express feelings about the outcome of the target event rather than giving a rational answer. This intent is strengthened by the formulation of the question (Experiment 1), which explicitly asks the subject to express the feeling connected to the lotteries and the absence of a third option (Experiment 1, 4), the right one, which expresses the “indifference” between the two options. In Experiment 4, the task lacks only the third option, and, simply by adding the option that allows subjects to express the correct answer, the RB disappears.
Effect of Synbiotics Fortification in Specific Baby Food Formulas on Iron , Calcium and Zinc Absorption

Synbiotics are the simultaneously administration processes of the probiotics and prebiotics combination. Inulin and oligosaccharides recently have anattracted more attentions as non digestible carbohydrates that are fermented bymicroflora especially bifidobacteria, in alarge bowel to short chain fatty acids fermentation and had a positive effect on mineral absorption. The objective of the present study is to investigate the in vivo biological estimation of prebiotics and probiotics combination (synbiotics) on Ca, Fe and Zn absorption in weaning age rats. Forty two, Western strain, male rats, aged two months, and about 60 ±5g weight were divided into 7 groups (6 rats for each group) as follows: group (1) fed on basil diet (BD) formula, (reference group), group (2) fed on a formulated baby food (control group),group (3) fed on the baby food supplemented with Bifidobacterium bifidum (Bb) at 8.95log cfu/g concentration, group (4) fed on baby food formula supplemented with 5% dried powder of Jerusalem artichoke tubers, (Ja) , group (5) fed on the baby food formula supplemented with 5%Ja+8.95 log cfu/g, group (6) fed on the baby food supplemented with 10%Ja and group (7) fed on baby food supplemented with 10% Ja+8.95 log cfu/g Bb. The experimental period continued 5 weeks. At fifth week, a controlled metabolic study was carried out. The obtained results indicated that bifidobacterial count was stable during storage for 6 months especially in the formulas which contain 10% of Ja which recorded the highest sensory scores. Supplementation of baby foods with prebiotic or / and probiotic did not significantly affected on mineral levels in serum except group (7) for serum Fe. Also, this supplementation increased the absorption of Ca especially at high dose of prebiotic and combined with bifidobacteria (group 7). Also, supplementation with bifidobacteria + 10 % Ja caused improvement in apparent iron and zinc absorption percent. In conclusion, supplementation the baby cereal foods with bifidobacteria and Jerusalem artichoke as a source of inulin had a beneficial effect on Zn, Fe and Ca absorption.
Endothelial proteoglycans inhibit bFGF binding and mitogenesis

Basic fibroblast growth factor (bFGF) is a known mitogen for vascular smooth muscle cells and has been implicated as having a role in a number of proliferative vascular disorders. Binding of bFGF to heparin or heparan sulfate has been demonstrated to both stimulate and inhibit growth factor activity. The activity, towards bFGF, of heparan sulfate proteoglycans present within the vascular system is likely related to the chemical characteristics of the glycosaminoglycan as well as the structure and pericellular location of the intact proteoglycans. We have previously shown that endothelial conditioned medium inhibits both bFGF binding to vascular smooth muscle cells and bFGF stimulated cell proliferation in vitro. In the present study, we have isolated proteoglycans from endothelial cell conditioned medium and demonstrated that they are responsible for the bFGF inhibitory activity. We further separated endothelial secreted proteoglycans into two fractions, PG‐A and PG‐B. The larger sized fraction (PG‐A) had greater inhibitory activity than did PG‐B for both bFGF binding and bFGF stimulation of vascular smooth muscle cell proliferation. The increased relative activity of PG‐A was attributed, in part, to larger heparan sulfate chains which were more potent inhibitors of bFGF binding than the smaller heparan sulfate chains on PG‐B. Both proteoglycan fractions contained perlecan‐like core proteins; however, PG‐A contained an additional core protein (approximately 190 kDa) that was not observed in PG‐B. Both proteoglycan fractions bound bFGF directly, and PG‐A bound a significantly greater relative amount of bFGF than did PG‐B. Thus the ability of endothelial heparan sulfate proteoglycans to bind bFGF and prevent its association with vascular smooth muscle cells appears essential for inhibition of bFGF‐induced mitogenesis. The production of potent bFGF inhibitory heparan sulfate proteoglycans by endothelial cells might contribute to the maintenance of vascular homeostasis. J. Cell. Physiol. 172:209–220, 1997. © 1997 Wiley‐Liss, Inc.
Soluble Receptor Potentiates Receptor-Independent Infection by Murine Coronavirus

ABSTRACT Mouse hepatitis virus (MHV) infection spreads from MHV-infected DBT cells, which express the MHV receptor CEACAM1 (MHVR), to BHK cells, which are devoid of the receptor, by intercellular membrane fusion (MHVR-independent fusion). This mode of infection is a property of wild-type (wt) JHMV cl-2 virus but is not seen in cultures infected with the mutant virus JHMV srr7. In this study, we show that soluble MHVR (soMHVR) potentiates MHVR-independent fusion in JHMV srr7-infected cultures. Thus, in the presence of soMHVR, JHMV srr7-infected DBT cells overlaid onto BHK cells induce BHK cell syncytia and the spread of JHMV srr7 infection. This does not occur in the absence of soMHVR. soMHVR also enhanced wt virus MHVR-independent fusion. These effects were dependent on the concentration of soMHVR in the culture and were specifically blocked by the anti-MHVR monoclonal antibody CC1. Together with these observations, direct binding of soMHVR to the virus spike (S) glycoprotein as revealed by coimmunoprecipitation demonstrated that the effect is mediated by the binding of soMHVR to the S protein. Furthermore, fusion of BHK cells expressing the JHMV srr7 S protein was also induced by soMHVR. These results indicated that the binding of soMHVR to the S protein expressed on the DBT cell surface potentiates the fusion of MHV-infected DBT cells with nonpermissive BHK cells. We conclude that the binding of soMHVR to the S protein converts the S protein to a fusion-active form competent to mediate cell-cell fusion, in a fashion similar to the fusion of virus and cell membranes.
Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia

Transformed epithelial cells often are characterized by a fibroblastic or mesenchymal morphology. These cells exhibit altered cell-cell and cell-substrate interactions. Here we have identified changes in the adhesions and cytoskeletal interactions of transformed epithelial cells that contribute to their altered morphology. Using MCF-10A human breast epithelial cells as a model system, we have found that transformation by an activated form of ras is characterized by less developed adherens- type junctions between cells but increased focal adhesions. Contributing to the modified adherens junctions of the transformed cells are decreased interactions among beta-catenin, E-cadherin, and the actin cytoskeleton. The ras-transformed cells reveal elevated phosphotyrosine in many proteins, including beta-catenin and p120 Cas. Whereas in the normal cells beta-catenin is found in association with E- cadherin, p120 Cas is not. In the ras-transformed cells, the situation is reversed; tyrosine-phosphorylated p120 Cas, but not tyrosine- phosphorylated beta-catenin, now is detected in E-cadherin complexes. The tyrosine-phosphorylated beta-catenin also shows increased detergent solubility, suggesting a decreased association with the actin cytoskeleton. p120 Cas, whether tyrosine phosphorylated or not, partitions into the detergent soluble fraction, suggesting that it is not tightly bound to the actin cytoskeleton in either the normal or ras- transformed cells. Inhibitors of tyrosine kinases decrease the level of tyrosine phosphorylation and restore a normal epithelial morphology to the ras-transformed cells. In particular, decreased tyrosine phosphorylation of beta-catenin is accompanied by increased interaction with both E-cadherin and the detergent insoluble cytoskeletal fraction. These results suggest that elevated tyrosine phosphorylation of proteins such as beta-catenin and p120 Cas contribute to the altered adherens junctions of ras-transformed epithelia.
Learning to Identify Review Spam

In the past few years, sentiment analysis and opinion mining becomes a popular and important task. These studies all assume that their opinion resources are real and trustful. However, they may encounter the faked opinion or opinion spam problem. In this paper, we study this issue in the context of our product review mining system. On product review site, people may write faked reviews, called review spam, to promote their products, or defame their competitors' products. It is important to identify and filter out the review spam. Previous work only focuses on some heuristic rules, such as helpfulness voting, or rating deviation, which limits the performance of this task. In this paper, we exploit machine learning methods to identify review spam. Toward the end, we manually build a spam collection from our crawled reviews. We first analyze the effect of various features in spam identification. We also observe that the review spammer consistently writes spam. This provides us another view to identify review spam: we can identify if the author of the review is spammer. Based on this observation, we provide a twoview semi-supervised method, co-training, to exploit the large amount of unlabeled data. The experiment results show that our proposed method is effective. Our designed machine learning methods achieve significant improvements in comparison to the heuristic baselines.
Tracheobronchial foreign bodies: a 10 year experience.

BACKGROUND Our aim is to describe foreign body aspiration in the tracheobronchial tree, a common emergency with serious consequences. METHODS We reviewed the records of 357 patients who were admitted to our hospital during a 10-year period for the treatment of aspirated foreign body into the tracheobronchial tree. RESULTS Of these cases, 42.4% were male and 57.6% female. Their ages ranged from 4 months to 70 years (average of 10.8 years). The most common manifestation was coughing, with subsequent dyspnea and wheezing. All underwent rigid bronchoscopy for the removal of the foreign body. Foreign bodies were localized in the right bronchial tree in 188 cases (52.7%), the left in 107 cases (30%) and trachea in 39 cases (10.9%). Foreign bodies were not found during bronchoscopy in 23 cases (6.4%). The foreign bodies were: needles (n=125), peanuts (n=110), plastic objects (n=52), and miscellaneous (n=47). Foreign bodies were removed by bronchoscopy in all but six cases (1.7%), who underwent limited thoracotomy. The present series had a mortality of 0.56 percent (two deaths) following removal of foreign body. CONCLUSIONS Foreign body aspiration are rapidly recognized from the patient's history and easily treated by bronchoscopy and extraction of the aspirated foreign body. A high index of suspicion is crucial for early diagnosis. However, education is the best preventive measure for decreasing the incidence of this matter.
High-speed, image-based eye tracking with a scanning laser ophthalmoscope

We demonstrate a high-speed, image-based tracking scanning laser ophthalmoscope (TSLO) that can provide high fidelity structural images, real-time eye tracking and targeted stimulus delivery. The system was designed for diffraction-limited performance over an 8° field of view (FOV) and operates with a flexible field of view of 1°–5.5°. Stabilized videos of the retina were generated showing an amplitude of motion after stabilization of 0.2 arcmin or less across all frequencies. In addition, the imaging laser can be modulated to place a stimulus on a targeted retinal location. We show a stimulus placement accuracy with a standard deviation less than 1 arcmin. With a smaller field size of 2°, individual cone photoreceptors were clearly visible at eccentricities outside of the fovea.
Electrophysiological Evidence for Biased Competition in V1 for Fear Expressions

When multiple stimuli are concurrently displayed in the visual field, they must compete for neural representation at the processing expense of their contemporaries. This biased competition is thought to begin as early as primary visual cortex, and can be driven by salient low-level stimulus features. Stimuli important for an organism's survival, such as facial expressions signaling environmental threat, might be similarly prioritized at this early stage of visual processing. In the present study, we used ERP recordings from striate cortex to examine whether fear expressions can bias the competition for neural representation at the earliest stage of retinotopic visuo-cortical processing when in direct competition with concurrently presented visual information of neutral valence. We found that within 50 msec after stimulus onset, information processing in primary visual cortex is biased in favor of perceptual representations of fear at the expense of competing visual information (Experiment 1). Additional experiments confirmed that the facial display's emotional content rather than low-level features is responsible for this prioritization in V1 (Experiment 2), and that this competition is reliant on a face's upright canonical orientation (Experiment 3). These results suggest that complex stimuli important for an organism's survival can indeed be prioritized at the earliest stage of cortical processing at the expense of competing information, with competition possibly beginning before encoding in V1.
Purification, Characterization, and Cloning of a Spodoptera frugiperda Sf9 β-N-Acetylhexosaminidase That Hydrolyzes Terminal N-Acetylglucosamine on the N-Glycan Core*

Paucimannosidic glycans are often predominant in N-glycans produced by insect cells. However, a β-N-acetylhexosaminidase responsible for the generation of paucimannosidic glycans in lepidopteran insect cells has not been identified. We report the purification of a β-N-acetylhexosaminidase from the culture medium of Spodoptera frugiperda Sf9 cells (Sfhex). The purified Sfhex protein showed 10 times higher activity for a terminal N-acetylglucosamine on the N-glycan core compared with tri-N-acetylchitotriose. Sfhex was found to be a homodimer of 110 kDa in solution, with a pH optimum of 5.5. With a biantennary N-glycan substrate, it exhibited a 5-fold preference for removal of the β(1,2)-linked N-acetylglucosamine from the Manα(1,3) branch compared with the Manα(1,6) branch. We isolated two corresponding cDNA clones for Sfhex that encode proteins with >99% amino acid identity. A phylogenetic analysis suggested that Sfhex is an ortholog of mammalian lysosomal β-N-acetylhexosaminidases. Recombinant Sfhex expressed in Sf9 cells exhibited the same substrate specificity and pH optimum as the purified enzyme. Although a larger amount of newly synthesized Sfhex was secreted into the culture medium by Sf9 cells, a significant amount of Sfhex was also found to be intracellular. Under a confocal microscope, cellular Sfhex exhibited punctate staining throughout the cytoplasm, but did not colocalize with a Golgi marker. Because secretory glycoproteins and Sfhex are cotransported through the same secretory pathway and because Sfhex is active at the pH of the secretory compartments, this study suggests that Sfhex may play a role as a processing β-N-acetylhexosaminidase acting on N-glycans from Sf9 cells.
Numerical Study on the Relationship among Air Permeability, Pore Size and Pressure Assuming Molecular and Viscous Flows

The relationship among air permeability, pressure, and pore size from a viscous- to a molecular-flow region is not well understood. In this work, air permeability in a straight circular pipe was studied considering viscous and molecular flows. I learned that the air-permeability coefficient and intrinsic air-permeability coefficient exhibit contrasting pressure dependence: that of the air-permeability coefficient is larger in a larger pore, whereas that of the intrinsic air-permeability coefficient is larger in a smaller pore. I thus proposed a method to obtain the air-permeability coefficient at atmospheric pressure from that measured under vacuum or pressurised condition. From the Reynolds number study, turbulent flow study is unnecessary in air flow in concrete.