Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Upper Bounds of Spread for Greedy Algorithms in Social Network Influence Maximization

Influence maximization, defined as finding a small subset of nodes that maximizes spread of influence in social networks, is NP-hard under both Independent Cascade (IC) and Linear Threshold (LT) models, where many greedy-based algorithms have been proposed with the best approximation guarantee. However, existing greedy-based algorithms are inefficient on large networks, as it demands heavy Monte-Carlo simulations of the spread functions for each node at the initial step [7]. In this paper, we establish new upper bounds to significantly reduce the number of Monte-Carlo simulations in greedy-based algorithms, especially at the initial step. We theoretically prove that the bound is tight and convergent when the summation of weights towards (or from) each node is less than 1. Based on the bound, we propose a new Upper Bound based Lazy Forward algorithm (UBLF in short) for discovering the top-k influential nodes in social networks. We test and compare UBLF with prior greedy algorithms, especially CELF [30]. Experimental results show that UBLF reduces more than 95 percent Monte-Carlo simulations of CELF and achieves about 2-10 times speedup when the seed set is small.
Feedback Control of a Cylinder Wake Low-Dimensional Model

Nomenclature Ak = time-dependent coef cient of the kth proper orthogonal decompositionmode Aest k = estimation of Ak B = matrix containing the bk coef cients bk = coef cients associatedwith the control input ck i j = coef cients of the nonlinear function gk fa = control input resulting form external forcing of the cylinder gk = nonlinear function of the time-dependent low-dimensionalmodes J = Jacobian of the open-loop low-dimensionalmodel Jc = closed-loop Jacobian K p = proportional gain of the linear feedback controller
Using of transcranial direct-current stimulation during motor task for a better outcome

De tout temps, les humains ont cherche differents moyens pour ameliorer leur quotidien. Avec les avancees technologiques actuelles, cette quete s’en trouve facilitee, notamment dans la volonte d’accroitre leurs capacites cognitives et/ou motrices. La neuro imagerie permet dorenavant de renseigner les aires cerebrales activees lors de differentes tâches fonctionnelles. Il est aussi possible de moduler l’activite cerebrale en stimulant localement le cerveau avec de faibles courants electriques. Une des techniques les plus repandues a cet effet est appelee tDCS pour transcranial direct current stimulation. Il s’agit en fonction de la polarite du courant induit de moduler a la hausse (stimulation anodale) ou a la baisse (stimulation cathodale) l’excitabilite cortico-spinale en depolarisant ou en hyperpolarisant la membrane des neurones, respectivement. Malgre une democratisation grandissante de la neuromodulation via tDCS, les resultats rapportes par la communaute scientifique sont relativement heterogenes. Les travaux inities au debut des annees 2000 sont remis en cause par des resultats actuels faisant etat d’une variabilite inter et intra individuelle assez importante. Cette pierre d’achoppement necessite de developper de nouveaux protocoles d’application de la tDCS. Dans cette these, nous avons etudie plusieurs modalites d’application de la tDCS afin d’accroitre la persistance des effets neuroplastiques induits et d’augmenter les performances comportementales. Deux etudes ont ete menees afin de reveler dans un premier temps les apports induits par le couplage tâche motrice-tDCS pour ensuite mettre en avant les effets cumulatifs de la repetition de sessions de tâche motrice-tDCS avec pre conditionnement sur la performance motrice. La premiere etude a travers l’utilisation de la spectroscopie dans le proche infrarouge a permis de rapporter des changements hemodynamiques distincts subsequents au couplage tâche motrice-tDCS par rapport a des protocoles tDCS plus conventionnels. La primaute de l’utilisation concomitante de la tDCS a la tâche motrice a ete revelee par la moindre activation du cortex sensorimoteur durant la stimulation ainsi que par une activation cerebrale retardee accrue qui pourrait representer une reorganisation neuroplastique. La seconde etude s’est interessee aux effets de la polarite du conditionnement lors de sessions repetees avec comme objectif d’ameliorer l’apprentissage et la retention du systeme sensorimoteur. Le conditionnement par tDCS etait plus propice lors de sessions repetees a engendrer des performances motrices superieures contrairement a la condition sham. La polarite cathodale engendrait une persistance prolongee. Les premiers resultats de ces travaux de these ont permis de defendre l’usage concomitant de la tDCS avec la tâche motrice. De futures recherches sont necessaires afin d’etudier le transfert de ces resultats dans le monde de l’entrainement ainsi que celui de la rehabilitation.
Nonlinear waves in Bose–Einstein condensates: physical relevance and mathematical techniques

The aim of this review is to introduce the reader to some of the physical notions and the mathematical methods that are relevant to the study of nonlinear waves in Bose–Einstein condensates (BECs). Upon introducing the general framework, we discuss the prototypical models that are relevant to this setting for different dimensions and different potentials confining the atoms. We analyse some of the model properties and explore their typical wave solutions (plane wave solutions, bright, dark, gap solitons as well as vortices). We then offer a collection of mathematical methods that can be used to understand the existence, stability and dynamics of nonlinear waves in such BECs, either directly or starting from different types of limits (e.g. the linear or the nonlinear limit or the discrete limit of the corresponding equation). Finally, we consider some special topics involving more recent developments, and experimental setups in which there is still considerable need for developing mathematical as well as computational tools.
Alkylphenol Xenoestrogens with Varying Carbon Chain Lengths Differentially and Potently Activate Signaling and Functional Responses in GH3/B6/F10 Somatomammotropes

Background Alkylphenols varying in their side-chain lengths [ethyl-, propyl-, octyl-, and nonylphenol (EP, PP, OP, and NP, respectively)] and bisphenol A (BPA) represent a large group of structurally related xenoestrogens that have endocrine-disruptive effects. Their rapid nongenomic effects that depend on structure for cell signaling and resulting functions are unknown. Objectives We compared nongenomic estrogenic activities of alkylphenols with BPA and 17β-estradiol (E2) in membrane estrogen receptor-α–enriched GH3/B6/F10 pituitary tumor cells. These actions included calcium (Ca) signaling, prolactin (PRL) release, extracellular-regulated kinase (ERK) phosphorylation, and cell proliferation. Methods We imaged Ca using fura-2, measured PRL release via radioimmunoassay, detected ERK phosphorylation by fixed cell immunoassay, and estimated cell number using the crystal violet assay. Results All compounds caused increases in Ca oscillation frequency and intracellular Ca volume at 100 fM to 1 nM concentrations, although long-chain alkylphenols were most effective. All estrogens caused rapid PRL release at concentrations as low as 1 fM to 10 pM; the potency of EP, PP, and NP exceeded that of E2. All compounds at 1 nM produced similar increases in ERK phosphorylation, causing rapid peaks at 2.5–5 min, followed by inactivation and additional 60-min peaks (except for BPA). Dose–response patterns of ERK activation at 5 min were similar for E2, BPA, and PP, whereas EP caused larger effects. Only E2 and NP increased cell number. Some rapid estrogenic responses showed correlations with the hydrophobicity of estrogenic molecules; the more hydrophobic OP and NP were superior at Ca and cell proliferation responses, whereas the less hydrophobic EP and PP were better at ERK activations. Conclusions Alkylphenols are potent estrogens in evoking these nongenomic responses contributing to complex functions; their hydrophobicity can largely predict these behaviors.
Nicorandil Prevents Right Ventricular Remodeling by Inhibiting Apoptosis and Lowering Pressure Overload in Rats with Pulmonary Arterial Hypertension

Background Most of the deaths among patients with severe pulmonary arterial hypertension (PAH) are caused by progressive right ventricular (RV) pathological remodeling, dysfunction, and failure. Nicorandil can inhibit the development of PAH by reducing pulmonary artery pressure and RV hypertrophy. However, whether nicorandil can inhibit apoptosis in RV cardiomyocytes and prevent RV remodeling has been unclear. Methodology/Principal Findings RV remodeling was induced in rats by intraperitoneal injection of monocrotaline (MCT). RV systolic pressure (RVSP) was measured at the end of each week after MCT injection. Blood samples were drawn for brain natriuretic peptide (BNP) ELISA analysis. The hearts were excised for histopathological, ultrastructural, immunohistochemical, and Western blotting analyses. The MCT-injected rats exhibited greater mortality and less weight gain and showed significantly increased RVSP and RV hypertrophy during the second week. These worsened during the third week. MCT injection for three weeks caused pathological RV remodeling, characterized by hypertrophy, fibrosis, dysfunction, and RV mitochondrial impairment, as indicated by increased levels of apoptosis. Nicorandil improved survival, weight gain, and RV function, ameliorated RV pressure overload, and prevented maladaptive RV remodeling in PAH rats. Nicorandil also reduced the number of apoptotic cardiomyocytes, with a concomitant increase in Bcl-2/Bax ratio. 5-hydroxydecanoate (5-HD) reversed these beneficial effects of nicorandil in MCT-injected rats. Conclusions/Significance Nicorandil inhibits PAH-induced RV remodeling in rats not only by reducing RV pressure overload but also by inhibiting apoptosis in cardiomyocytes through the activation of mitochondrial ATP-sensitive K+ (mitoKATP) channels. The use of a mitoKATP channel opener such as nicorandil for PAH-associated RV remodeling and dysfunction may represent a new therapeutic strategy for the amelioration of RV remodeling during the early stages of PAH.
Institute for Mathematical Physics Dirac Geometry, Quasi–poisson Actions and D/g–valued Moment Maps Dirac Geometry, Quasi-poisson Actions and D/g-valued Moment Maps

We study Dirac structures associated with Manin pairs (d, g) and give a Dirac geometric approach to Hamiltonian spaces with D/G-valued moment maps, originally introduced by Alekseev and Kosmann-Schwarzbach [3] in terms of quasi-Poisson structures. We explain how these two distinct frameworks are related to each other, proving that they lead to isomorphic categories of Hamiltonian spaces. We stress the connection between the viewpoint of Dirac geometry and equivariant differential forms. The paper discusses various examples, including q-Hamiltonian spaces and Poisson-Lie group actions, explaining how presymplectic groupoids are related to the notion of " double " in each context.
In vivo retinal gene expression in early diabetes.

PURPOSE Studies have demonstrated a causal role for specific molecules in the pathogenesis of diabetic retinopathy. Among the implicated mediators are growth factors such as vascular endothelial growth factor (VEGF) as well as adhesion molecules and proliferation- and apoptosis-related genes. However, a coordinated large-scale investigation of gene expression in the diabetic retina has not yet been reported. Here the retinal gene expression profile of diabetic and nondiabetic animals using cDNA microarrays were analyzed and compared. METHODS Long-Evans rats were made diabetic with streptozotocin. Retinal gene expression was analyzed over 3 weeks using high-density nylon filter-based cDNA arrays. Genes were sorted into clusters according to their temporal expression profiles. They were also grouped according to their potential pathophysiological significance. The in vivo gene expression profiles of selected genes were verified via RNase protection assay. RESULTS The rat GeneFilter contains a total of 5147 genes, of which 1691 are known genes and 3456 are expressed sequence tags (ESTs). On day 3, the expression of 27 known genes was increased by more than twofold. On days 7 and 21, the corresponding numbers were 60 and 12, respectively. A transient upregulation (>2-fold) in expression was seen in 627 of 5147 total genes. A subset of 926 genes exhibited a modest (<2-fold) decrease in expression. No genes showed a greater than twofold decrease in expression. Overall, the identity of the genes that were upregulated suggests that the response of the retina to the diabetic challenge contains an inflammatory component. Moreover, most regulatory activity occurs during the first week of diabetes. CONCLUSIONS The development of a rational therapy for diabetic retinopathy will be assisted by detailed knowledge regarding the molecular pathophysiology of the disease. Here, an expression profile of an underlying retinal inflammatory process in early diabetes was extracted. Beyond providing insight into the general nature of the response to a pathogenic challenge, gene expression profiling may also allow the efficient identification of potential drug targets and markers for monitoring the course of disease.
International Journal of Hospitality Management Knowledge Management, Social Media and Employee Creativity

The study investigates the relation between social media use and employee creativity by adopting a knowledge management (KM) approach in order to consider the influence of social networks and interactions on individuals' creativity. The literature review debates how the use of social media empowers people to engage in conversational and collaborative KM, which in turn enriches people's cognitive and creative processes. Data collected from Greek tourism professionals confirmed that employees' creativity is positively related to their participation in social networks and their use of social media for: searching, storing and reading information (internal cognitive processes); and sharing, discussing and co-creating information (external cognitive processes). The study contributes to the field by providing a theoretical underpinning and practical evidence showing how social networks (i.e. a meso level) can influence employees' creativity. Hence, the findings highlight the need to shift focus from identifying and managing creative individuals (micro level) and/or organisational contexts (macro level) to creating and managing creative social networks (meso level).
Macrophages and Leydig Cells in Testicular Biopsies of Azoospermic Men

A number of studies have indicated that testicular macrophages play an important role in regulating steroidogenesis of Leydig cells and maintain homeostasis within the testis. The current paper deals with macrophages (CD68 positive cells) and Leydig cells in patients with nonobstructive azoospermia (NOA). Methods employed included histological analysis on semi- and ultrathin sections, immunohistochemistry, morphometry, and hormone analysis in the blood serum. Histological analysis pointed out certain structural changes of macrophages and Leydig cells in NOA group of patients when compared to controls. In the testis interstitium, an increased presence of CD68 positive cells has been noted. Leydig cells in NOA patients displayed a kind of a mosaic picture across the same bioptic sample: both normal and damaged Leydig cells with pronounced vacuolisation and various intensity of expression of testosterone have been observed. Stereological analysis indicated a significant increase in volume density of both CD68 positive and vacuolated Leydig cells and a positive correlation between the volume densities of these cell types. The continuous gonadotropin overstimulation of Leydig cells, together with a negative paracrine action of macrophages, could result in the damage of steroidogenesis and deficit of testosterone in situ.
Neurotrophic Effect of Adipose Tissue-Derived Stem Cells on Erectile Function Recovery by Pigment Epithelium-Derived Factor Secretion in a Rat Model of Cavernous Nerve Injury

The paracrine effect is the major mechanism of stem cell therapy. However, the details of the effect's mechanism remain unknown. The aim of this study is to investigate whether adipose tissue-derived stem cells (ADSCs) can ameliorate cavernous nerve injury-induced erectile dysfunction (CNIED) rats and to determine its mechanism. Twenty-eight days after intracavernous injection of 5-ethynyl-2-deoxyuridine- (EdU-) labeled ADSCs, the erectile function of all the rats was evaluated by intracavernosal pressure (ICP). The ADSCs steadily secreted detectable pigment epithelium-derived factor (PEDF) in vitro. The expression of PEDF increased in the penis of the bilateral cavernous nerve injury (BCNI) group for 14 days and then gradually decreased. On day 28 after the intracavernous injection, the ADSCs group exhibited a significantly increased ICP compared with the phosphate buffered saline- (PBS-) treated group. Moreover, the neuronal nitric oxide synthase (nNOS) and S100 expression in penile dorsal nerves and the smooth muscle content to collagen ratio in penile tissues significantly increased. Furthermore, elevated PEDF, p-Akt, and p-eNOS were identified in the ADSCs group. This study demonstrated that intracavernous injection of ADSCs improved erectile function, repaired the nerve, and corrected penile fibrosis. One potential mechanism is the PEDF secretion of ADSCs and subsequent PI3K/Akt pathway activation.
Rule Pruning in Associative Classification Mining

Classification and association rule discovery are important data mining tasks. Using association rule discovery to construct classification systems, also known as associative classification, is a promising approach. In this paper, we survey different rule pruning methods used by associative classification techniques. Furthermore, we compare the effect of three pruning methods (database coverage, pessimistic error estimation, lazy pruning) on the number of rules derived from different classification data sets. Results obtained from experimenting on fourteen data sets from the UCI data collection show the need for additional constraints during pruning in associative classification in order to decrease further the size of the resulting classifiers. The results also indicate that lazy pruning algorithms generate very large number of rules if compared with other associative algorithms. This may reduce their use for data mining applications where a concise set of rules is required.
Evolutionary synthesis of stellar populations: a modular tool

A new tool for the evolutionary synthesis of stellar populations is presented, which is based on three independent matrices, giving respectively (1) the fuel consumption during each evolutionary phase as a function of stellar mass, (2) the typical temperatures and gravities during such phases, and (3) the colours and bolometric corrections as functions of gravity and temperature. The modular structure of the code allows one easily to assess the impact on the synthetic spectral energy distribution of the various assumptions and model ingredients, such as, for example, uncertainties in stellar evolutionary models, the mixing length, the temperature distribution of horizontal branch stars, asymptotic giant branch mass loss, and colour–temperature transformations. The so-called ‘AGB phase transition’ in Magellanic Cloud clusters is used to calibrate the contribution of the thermally pulsing asymptotic giant branch phase to the synthetic integrated luminosity. As an illustrative example, solar-metallicity (Y = 0.27, Z = 0.02) models, with ages ranging between 30 Myr and 15 Gyr and various choices for the slope of the initial mass function, are presented. Synthetic broad-band colours and the luminosity contributions of the various evolutionary stages are compared with Large Magellanic Cloud and Galactic globular cluster data. In all these cases, a good agreement is found. Finally, the evolution is presented of stellar mass-to-light ratios in the bolometric and UBVRK passbands, in which the contribution of stellar remnants is accounted for.
Faktor-faktor yang mempengaruhi tingkat pengangguran dan kemiskinan di kota samarinda

Penelitian ini bertujuan untuk menganalisis dan mengetahui pengaruh pertumbuhan ekonomi, upah minimum kota (UMK), tingkat pendidikan, dan inflasi terhadap tingkat pengangguran dan kemiskinan di Kota Samarinda. Data yang digunakan dalam penelitian ini adalah data sekunder pada tahun 2005-2014. Alat analisis yang digunakan adalah analisis jalur ( path analysis ). Perangkat lunak yang digunakan untuk melakukan analisis adalah IBM-SPSS Versi 23. Hasil penelitian menunjukkan bahwa dalam mempengaruhi tingkat pengangguran, pertumbuhan ekonomiberpengaruh langsung dan tidak signifikan dengan nilai pengaruh 0,269 dan signifikansi 0,177> 0,10, upah minimum kotaberpengaruh langsung dan signifikan dengan nilai pengaruh -1,269 dan signifikansi 0,032 0,10, sertainflasi berpengaruh langsung dan tidak signifikan dengan nilai pengaruh 0,184 dan signifikansi 0,352>0,10.Dalam mempengaruhi tingkat kemiskinan, pertumbuhan ekonomiberpengaruh langsung dan signifikan dengan nilai pengaruh -0,607 dan signifikansi sebesar 0,067 0,10, tingkat pendidikan berpengaruh langsung dan signifikan dengan nilai pengaruh -1,350 dan signifikansi 0,079 0,10, serta tingkat pengangguranberpengaruh langsung dan signifikan dengan nilai pengaruh 1,400 dan signifikansi 0,054 <0,10.Dalam mempengaruhi tingkat kemiskinan melalui tingkat pengangguran, pertumbuhan ekonomi berpengaruh tidak langsung dan tidak signifikan dengan nilai pengaruh 0,3766, upah minimum kotaberpengaruh tidak langsung dan signifikan dengan nilai pengaruh -1,7766, tingkat pendidikan berpengaruh tidak langsung dan tidak signifikan dengan nilai pengaruh 0,7756, serta inflasiberpengaruh tidak langsung dan tidak signifikan dengan nilai pengaruh 0,2576.
Influence of environment on the content and composition of microbial free amino acid pools.

SUMMARY: The free amino acid pool contents of Gram-negative bacteria (Aerobacter aerogenes, Erwinia carotovora, Pseudomonas fluorescens) were studied as functions of the growth environment and were compared with those from correspondingly grown cultures of Gram-positive bacteria (Bacillus subtilis var. niger, B. megaterium, B. polymyxa) and the yeast Saccharomyces cerevisiae. Although the pools of the Gram-positive bacteria and the yeast contained five to 20 times the concentration of free amino acids present in the pools of Gram-negative bacteria, all pools were similar in containing only a limited range of detectable amino acids. Glutamate invariably predominated and generally accounted for over 50% of the total amino acid content of the pool. The contents and composition of pools from micro-organisms maintained in steady states in chemostat cultures did not vary with time, but changed significantly with changes in either growth rate or the nature of the growth limitation. However, these pool variations were small compared with those resulting from addition of 2% (w/v) NaCl to a culture of growing bacteria. With cultures of Gram-negative bacteria, sudden changes in medium salinity effected marked and rapid changes in free glutamate content; with Gram-positive bacteria, similar changes occurred, but extremely slowly. Addition of 4% (w/v) NaCl to growing yeast cultures brought about no observed changes in pool size or composition. These results are discussed with reference to the involvement of free amino acids in synthesis and functioning of microorganisms.