Miracle-dz/UniFAR-FTUs huggingface dataset:
The Mathematical Understandings That Prospective Teachers Bring to Teacher Education

This article focuses on the subject matter knowledge of preservice elementary and secondary mathematics teachers. In order to examine what teacher candidates understand about mathematics as they enter formal teacher education, results from questionnaires and interviews with 252 prospective teachers participating in a large study of teacher education are discussed. The results reveal the mathematical understandings that these elementary and secondary teacher candidates brought with them to teacher education from their precollege and college mathematics experiences, understandings that tended to be rule-bound and thin. Based on these data, the article challenges 3 common assumptions about learning to teach elementary or secondary mathematics: (1) that traditional school mathematics content is not difficult, (2) that precollege education provides teachers with much of what they need to know about mathematics, and (3) that majoring in mathematics ensures subject matter knowledge. These assumptions underlie current teacher education practices as well as proposals to reform the preparation of teachers.
Spray‐dried plasma and fresh frozen plasma modulate permeability and inflammation in vitro in vascular endothelial cells

After major traumatic injury, patients often require multiple transfusions of fresh frozen plasma (FFP) to correct coagulopathy and to reduce bleeding. A spray‐dried plasma (SDP) product has several logistical benefits over FFP use in trauma patients with coagulopathy. These benefits include ease of transport, stability at room temperature, and rapid reconstitution for infusion. Our past work suggests that FFP promotes endothelial stability by inhibiting endothelial permeability.
Personality and Roommate Friendship in Chinese Culture

This study examines the relationship of personality traits to mutual friendship among assigned roommates. It was designed to compare actual and perceived personality similarity and of personality desirability on friendship outcomes in a Chinese cultural setting. Hong Kong university students rated their own and their roommate’s personality on a comprehensive, indigenous measure six months after being paired to room together in the campus dormitories. Wright’s (1991) Acquaintance Description Form was completed by each roommate to assess their friendship. Those roommate pairs where each rated the friendship high were compared with those where each rated the friendship low. The decisive personality variable associated with mutual friendship was the roommate’s perceived higher level on four of the eight desirable dimensions of Chinese personality, namely helpfulness, intellect, openness to experience, and extroversion. There were no associations to friendship for the other roommate’s actual self-ratings on any of these eight dimensions; nor was friendship related to roommate similarity in personality, whether actual or perceived. These results for perceived roommate desirability in personality are discussed in light of related Western research and the constraints which apply to the assigned roommate relationship.
The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells

Clinical trials have shown that administration of the nematode Trichuris suis can be beneficial in treating various immune disorders. To provide insight into the mechanisms by which this worm suppresses inflammatory responses, an active component was purified from T. suis soluble products (TsSPs) that suppress TNF and IL‐12 secretion from LPS‐activated human dendritic cells (DCs). Analysis by liquid chromatography tandem mass spectrometry identified this compound as prostaglandin (PG)E2. The purified compound showed similar properties compared with TsSPs and commercial PGE2 in modulating LPS‐induced expression of many cytokines and chemokines and in modulating Rab7B and P2RX7 expression in human DCs. Furthermore, the TsSP‐induced reduction of TNF secretion from DCs is reversed by receptor antagonists for EP2 and EP4, indicating PGE2 action. T. suis secretes extremely high amounts of PGE2 (45–90 ng/mg protein) within their excretory/secretory products but few related lipid mediators as established by metabololipidomic analysis. Culture of T. suis with several cyclooxygenase (COX) inhibitors that inhibit mammalian prostaglandin synthesis affected the worm's motility but did not inhibit PGE2 secretion, suggesting that the worms can synthesize PGE2 via a COX‐independent pathway. We conclude that T. suis secretes PGE2 to suppress proinflammatory responses in human DCs, thereby modulating the host's immune response. —Laan, L. C. , Williams, A. R. , Stavenhagen, K. , Giera, M. , Kooij, G. , Vlasakov, I. , Kalay, H. , Kringel, H. , Nejsum, P., Thamsborg, S. M. , Wuhrer, M. , Dijkstra, C. D. , Cummings, R. D. , van Die, I. The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells. FASEB J. 31, 719–731 (2017). http://www.fasebj. org
Ototoxicity from Combined Cisplatin and Radiation Treatment: An In Vitro Study

Objective. Combined cisplatin (CDDP) and radiotherapy is increasingly being used to treat advanced head and neck cancers. As both CDDP and radiation can cause hearing loss, it is important to have a better understanding of the cellular and molecular ototoxic mechanisms involved in combined therapy. Procedure. The effects of CDDP, radiation, and combined CDDP-radiation on the OC-k3 cochlear cell line were studied using MTS assay, flow cytometry, Western blotting, and microarray analysis. Results. Compared to using CDDP or radiation alone, its combined use resulted in enhanced apoptotic cell death and apoptotic-related gene expression, including that of FAS. Phosphorylation of p53 at Ser15 (a marker for p53 pathway activation in response to DNA damage) was observed after treatment with either CDDP or radiation. However, posttreatment activation of p53 occurred earlier in radiation than in CDDP which corresponded to the timings of MDM2 and TP53INP1 expression. Conclusion. Enhanced apoptotic-related gene expressions leading to increased apoptotic cell deaths could explain the synergistic ototoxicity seen clinically in combined CDDP-radiation therapy. CDDP and radiation led to differential temporal activation of p53 which suggests that their activation is the result of different upstream processes. These have implications in future antiapoptotic treatments for ototoxicity.
A new row decoding architecture for fast wordline charging in NOR type Flash memories

This paper presents a new row decoding architecture implemented in 90nm STM10 triple well CMOS technology for low supply voltage, high speed NOR type Flash memories. The overall design is complemented with a novel stress relaxed high/low or positive/negative level shifter for converting the digital signals operating at 1.2V to higher supply voltages for high voltage applications. The proposed level shifter achieves faster switching speed with low power consumption and less variation with respect to process and temperature.
Why does organizational identification relate to reduced employee burnout? The mediating influence of social support and collective efficacy

Although prior studies have consistently shown that organizational identification can reduce employees' stress and burnout, little is known about the mediating processes that underlie this relationship. Against this backdrop and building on recent theoretical work on the social identity model of stress, the present research tests a two-step mediation model for the organizational identification–burnout link. Specifically, it is hypothesized that employees who strongly identify with their organization are particularly likely to receive social support from their colleagues. This, in turn, should promote a sense of collective efficacy and, as a consequence, negatively relate to burnout. Data from a study with 192 Italian high schoolteachers supported the hypotheses.
Exposure to Diflubenzuron Results in an Up-Regulation of a Chitin Synthase 1 Gene in Citrus Red Mite, Panonychus citri (Acari: Tetranychidae)

Chitin synthase synthesizes chitin, which is critical for the arthropod exoskeleton. In this study, we cloned the cDNA sequences of a chitin synthase 1 gene, PcCHS1, in the citrus red mite, Panonychus citri (McGregor), which is one of the most economically important pests of citrus worldwide. The full-length cDNA of PcCHS1 contains an open reading frame of 4605 bp of nucleotides, which encodes a protein of 1535 amino acid residues with a predicted molecular mass of 175.0 kDa. A phylogenetic analysis showed that PcCHS1 was most closely related to CHS1 from Tetranychus urticae. During P. citri development, PcCHS1 was constantly expressed in all stages but highly expressed in the egg stage (114.8-fold higher than in the adult). When larvae were exposed to diflubenzuron (DFB) for 6 h, the mite had a significantly high mortality rate, and the mRNA expression levels of PcCHS1 were significantly enhanced. These results indicate a promising use of DFB to control P. citri, by possibly acting as an inhibitor in chitin synthesis as indicated by the up-regulation of PcCHS1 after exposure to DFB.
Classroom behaviour management: educational psychologists' views on effective practice

The behaviour of children and young people in schools is a perennial concern to educators and the wider public alike. It also represents a significant focus for the work of educational psychologists (EPs). Research evidence has identified a number of strategies that teachers, students and school inspectors believe contribute to effective classroom behaviour management (CBM). Psychological theory has also been used to inform approaches to CBM. This study focuses on EPs' views about effective CBM. EPs within one educational psychology service completed an activity which involved them identifying strategies they considered were most effective for CBM. Their responses were analysed using thematic analysis. A number of psychological functions or mechanisms underlying effective CBM strategies were identified. Based on these mechanisms an approach to CBM is advocated which draws from differing psychological paradigms and principles, and which suggests that effective CBM strategies and practices should be implemented at different systemic levels. Limitations of the present study and possibilities for future research are discussed.
18F-FDG PET/CT for Staging and Restaging of Breast Cancer

Many studies have pointed out the role of 18F-FDG PET/CT (or 18F-FDG PET) in patients with clinical stage III or II breast cancer. 18F-FDG PET/CT might advantageously replace other staging procedures, such as bone scanning and possibly contrast-enhanced CT of the thorax or abdomen–pelvis. We discuss the findings, locoregional or distant, that can be expected in different categories of breast cancer and their impact on prognosis and management. We also discuss the role of 18F-FDG PET/CT in restaging and how 18F-FDG PET/CT compares with conventional techniques in restaging for patients with suspected disease recurrence. We conclude with some recommendations for clinical practice and future research.
Pharmacological Management of Osteoporosis in Nursing Home Populations: A Systematic Review

Nursing home (NH) residents fall 11 times as frequently as their age‐matched community‐dwelling counterparts. The benefits of fall prevention strategies and hip protectors in terms of fracture risk in this setting are unclear. Moreover, there is no consensus on the efficacy of osteoporosis medication in NH residents. A systematic review was conducted to evaluate the efficacy of medications for osteoporosis in this population and to examine utilization studies in the NH setting to define prescribing practices. Electronic searches of MEDLINE, EMBASE, CINAHL, and the Cochrane Central Register of Controlled Trials were supplemented with a hand search of bibliographies. All English‐language studies published between January 1, 1974, and December 31, 2006, that studied osteoporosis pharmacotherapy in the NH environment were obtained, and studies of medication benefits and utilization patterns were identified. No restrictions were placed on study method. Studies required inclusion of NH patients and extractable data with bone mineral density (BMD) or fracture outcomes. Forty full‐text articles were retrieved, of which 15 studies met selection criteria. In the nine studies examining medication effects, calcium (1,200 mg) and vitamin D (800 IU) supplementation were shown to reduce fracture risk and improve BMD. One study supported the role of alendronate, but none documented the utility of raloxifene, calcitonin, or teriparatide in NH residents. All six medication utilization studies reported infrequent use of osteoporosis medications (9–25%). Prescribing for elderly NH patients is difficult, considering the risk:benefit ratio and issues of longevity, but these medications may be underused in the NH environment.
Urinary Bisphenol A Concentrations and Implantation Failure among Women Undergoing in Vitro Fertilization

Background: Bisphenol A (BPA) is a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins found in numerous consumer products. In experimental animals, BPA increases embryo implantation failure and reduces litter size. Objective: We evaluated the association of urinary BPA concentrations with implantation failure among women undergoing in vitro fertilization (IVF). Methods: We used online solid phase extraction–high performance liquid chromatography–isotope dilution tandem mass spectrometry to measure urinary BPA concentrations in 137 women in a prospective cohort study among women undergoing IVF at the Massachusetts General Hospital Fertility Center in Boston, Massachusetts. We used logistic regression to evaluate the association of cycle-specific urinary BPA concentrations with implantation failure, accounting for correlation among multiple IVF cycles in the same woman using generalized estimating equations. Implantation failure was defined as a negative serum β-human chorionic gonadotropin test (β-hCG < 6 IU/L) 17 days after egg retrieval. Results: Among 137 women undergoing 180 IVF cycles, urinary BPA concentrations had a geometric mean (SD) of 1.53 (2.22) µg/L. Overall, 42% (n = 75) of the IVF cycles resulted in implantation failure. In adjusted models, there was an increased odds of implantation failure with higher quartiles of urinary BPA concentrations {odds ratio (OR) 1.02 [95% confidence interval (CI): 0.35, 2.95}, 1.60 (95% CI: 0.70, 3.78), and 2.11 (95% CI: 0.84, 5.31) for quartiles 2, 3, and 4, respectively, compared with the lowest quartile (p-trend = 0.06). Conclusion: There was a positive linear dose–response association between BPA urinary concentrations and implantation failure.
Single molecule fluorescent in situ hybridization (smFISH) of C. elegans worms and embryos.

To whom correspondence should be addressed. E-mail: a.vanoudenaarden@hubrecht.eu. Single molecule fluorescent in situ hybridization (smFISH) of C. elegans worms and embryos Ni Ji and Alexander van Oudenaarden Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA, Hubrecht Institute, Royal Netherlands Academy of Arts and Science and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
Dendritic stratification differs among retinal OFF bipolar cell types in the absence of rod photoreceptors

Retinal OFF bipolar cells show distinct connectivity patterns with photoreceptors in the wild-type mouse retina. Some types are cone-specific while others penetrate further through the outer plexiform layer (OPL) to contact rods in addition to cones. To explore dendritic stratification of OFF bipolar cells in the absence of rods, we made use of the ‘cone-full’ Nrl-/- mouse retina in which all photoreceptor precursor cells commit to a cone fate including those which would have become rods in wild-type retinas. The dendritic distribution of OFF bipolar cell types was investigated by confocal and electron microscopic imaging of immunolabeled tissue sections. The cells’ dendrites formed basal contacts with cone terminals and expressed the corresponding glutamate receptor subunits at those sites, indicating putative synapses. All of the four analyzed cell populations showed distinctive patterns of vertical dendritic invasion through the OPL. This disparate behavior of dendritic extension in an environment containing only cone terminals demonstrates type-dependent specificity for dendritic outgrowth in OFF bipolar cells: rod terminals are not required for inducing dendritic extension into distal areas of the OPL.
Anaerobes and Bacterial Vaginosis in Pregnancy: Virulence Factors Contributing to Vaginal Colonisation

The aetiology and pathogenesis of bacterial vaginosis (BV) is unclear but it appears to be associated with factors that disrupt the normal acidity of the vagina thus altering the equilibrium between the normal vaginal microbiota. BV has serious implications for female morbidity, including reports of pelvic inflammatory disease, adverse pregnancy outcomes, increased susceptibility to sexually transmitted infections and infertility. This paper reviewed new available information regarding possible factors contributing to the establishment of the BV vaginal biofilm, examined the proposed role of anaerobic microbial species recently detected by new culture-independent methods and discusses developments related to the effects of BV on human pregnancy. The literature search included Pubmed (NLM), LISTA (EBSCO), and Web of Science. Because of the complexity and diversity of population groups, diagnosis and methodology used, no meta-analysis was performed. Several anaerobic microbial species previously missed in the laboratory diagnosis of BV have been revealed while taking cognisance of newly proposed theories of infection, thereby improving our understanding and knowledge of the complex aetiology and pathogenesis of BV and its perceived role in adverse pregnancy outcomes.
Evaluating Positional Head-Tracking in Immersive VR for 3D Designers

With the ongoing introduction of wide-FOV VR head-worn displays into the consumer market, the application of VR 3D UIs to professional work environments is attracting increasing attention. One of the most conspicuous concepts is immersive 3D modeling and content creation. In spite of the long research history, there have been very few analyses of the effect of 3D UIs on productivity in 3D design. In this work, we explore the effect of positional head-tracking on task performance in 3D design. Previous studies have come to different conclusions on the importance of headtracking and did not investigate professional 3D modeling tools. In contrast, we performed a user study with design students using professional software on a task that closely emulates their work. Surprisingly, we did not find a significant effect of head-tracking on task-completion time, neither when using a traditional 2D mouse nor when using a pinch glove as a 3D input device.
The global burden of other musculoskeletal disorders: estimates from the Global Burden of Disease 2010 study

Objective To estimate disability from the remainder of musculoskeletal (MSK) disorders (categorised as other MSK) not covered by the estimates made specifically for osteoarthritis (OA), rheumatoid arthritis (RA), gout, low back pain and neck pain, as part of the Global Burden of Disease (GBD) 2010 study. Methods Systematic reviews were conducted to gather the age-sex-specific epidemiological data for other MSK. The focus was on finding health surveys and published studies that measured the overall amount of MSK disorders and complaints, and classified the remainder of MSK disorders that was not RA, OA, gout, low back or neck pain. Six levels of severity were defined to derive disability weights (DWs) and severity distribution. The data, DWs and severity distribution were used to calculate years of life lived with disability (YLDs). Mortality was estimated for MSK-related deaths classified under other MSK. YLDs were added to years of life lost (YLLs) from the mortality estimates to derive overall burden in disability-adjusted life years (DALYs). Results Global prevalence of other MSK was 8.4% (95% uncertainty interval (UI) 8.1% to 8.6%). DALYs increased from 20.6 million (95% UI 17.0 to 23.3 million) in 1990 to 30.9 million (95% UI 25.8 to 34.6 million) in 2010. The burden of other MSK increased with age. Globally, other MSK disability burden (YLD) ranked sixth. Conclusions Ageing of the global population will further increase the burden of other MSK. Specific MSK conditions within this large category should be considered separately to enable more explicit estimates of their burden in future iterations of GBD.
Potent Inhibition of miR-34b on Migration and Invasion in Metastatic Prostate Cancer Cells by Regulating the TGF-β Pathway

The importance of miRNAs in the progression of prostate cancer (PCa) has further been supported by the finding that miRNAs have been identified as potential oncogenes or tumor suppressors in PCa. Indeed, in eukaryotes, miRNAs have been found to regulate and control gene expression by degrading mRNA at the post-transcriptional level. In this study, we investigated the expression of miR-34 family members, miR-34b and miR-34c, in different PCa cell lines, and discussed the molecular mechanism of miR-34b in the invasion and migration of PCa cells in vitro. The difference analyses of the transcriptome between the DU145 and PC3 cell lines demonstrated that both miR-34b and -34c target critical pathways that are involved in metabolism, such as proliferation, and migration, and invasion. The molecular expression of miR-34b/c were lower in PC3 cells. Moreover, over-expression of miR-34b/c in PC3 cells caused profound phenotypic changes, including decreased cell proliferation, migration and invasion. Moreover, the players that regulate expression levels of transforming growth factor-β (TGF-β), TGF-β receptor 1 (TGF-βR1), and p53 or phosphorylation levels of mothers against decapentaplegic 3 (SMAD3) in the TGF-β/Smad3 signaling pathway have yet to be elucidated, and will provide novel tools for diagnosis and treatment of metastatic PCa.
Developmental Cognitive Neuroscience Neural Circuitry of Masked Emotional Face Processing in Youth with Bipolar Disorder, Severe Mood Dysregulation, and Healthy Volunteers

Keywords: Bipolar disorder Adolescence Mood disorder Functional neuroimaging Backwards masking Affective priming a b s t r a c t Youth with bipolar disorder (BD) and those with severe, non-episodic irritability (severe mood dysregulation, SMD) show face-emotion labeling deficits. These groups differ from healthy volunteers (HV) in neural responses to emotional faces. It is unknown whether awareness is required to elicit these differences. We compared activation in BD (N = 20), SMD (N = 18), and HV (N = 22) during " Aware " and " Non-aware " priming of shapes by emotional faces. Subjects rated how much they liked the shape. In aware, a face (angry, fearful , happy, neutral, blank oval) appeared (187 ms) before the shape. In non-aware, a face appeared (17 ms), followed by a mask (170 ms), and shape. A Diagnosis-by-Awareness-by-Emotion ANOVA was not significant. There were significant Diagnosis-by-Awareness interactions in occipital regions. BD and SMD showed increased activity for non-aware vs. aware; HV showed the reverse pattern. When subjects viewed angry or neutral faces, there were Emotion-by-Diagnosis interactions in face-emotion processing regions, including the L precentral gyrus, R posterior cingulate, R superior temporal gyrus, R middle occipital gyrus, and L medial frontal gyrus. Regardless of awareness, BD and SMD differ in activation patterns from HV and each other in multiple brain regions, suggesting that BD and SMD are distinct developmental mood disorders.