Miracle-dz/UniFAR-FTUs huggingface dataset:
Antithrombotic drugs and non-variceal bleeding outcomes and risk scoring systems: comparison of Glasgow Blatchford, Rockall and Charlson scores

Objectives Antithrombotic drugs (ATDs) cause non-variceal upper gastrointestinal bleeding (NVUGIB). Risk scoring systems have not been validated in ATD users. We compared Blatchford, Rockall and Charlson scores in predicting outcomes of NVUGIB in ATD users and controls. Methods A total of 2071 patients with NVUGIB were grouped into ATD users (n=851) and controls (n=1220) in a single-centre retrospective analysis. Outcomes included duration of hospital admission, the need for blood transfusion, rebleeding requiring surgery and 30-day mortality. Results Duration of admission correlated with all scores in controls, but correlations were significantly weaker in ATD users. Rank correlation coefficients in control versus ATD: 0.45 vs 0.20 for Blatchford; 0.48 vs 0.32 for Rockall and 0.42 vs 0.26 for Charlson (all p<0.001). The need for transfusion was best predicted by Blatchford (p<0.001 vs Rockall and Charlson in both ATD users and controls), but all scores performed less well in ATD users. Area under the receiver operation characteristic curve (AUC) in control versus ATD: 0.90 vs 0.85 for Blatchford; 0.77 vs 0.61 for Rockall and 0.69 vs 0.56 for Charlson (all p<0.005). In predicting surgery, Rockall performed best; while mortality was best predicted by Charlson with lower AUCs in ATD patients than controls (p<0.05). Stratification showed the scores' performance to be age-dependent. Conclusions Blatchford score was the strongest predictor of transfusion, Rockall's had the strongest correlation with duration of admission and with rebleeding requiring surgery and Charlson was best in predicting 30-day mortality. Modifications of these systems should be explored to improve their efficiency in ATD users.
Fault current contributions from wind plants

This report examines several design and performance factors of WTGs connected to a power grid. The interconnection configuration, collector system design, generator type and selection of protection systems are described. The topics of this report provide engineers with an understanding of the consequences of the WTG plant design on short circuit contributions and the implications on the protection systems.
Characterization of a human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome

gpL115 is a lymphocyte surface component that is deficient in patients with the X-chromosome-linked immune deficiency Wiskott-Aldrich syndrome (6). The glycoprotein nature of gpL115 is demonstrated through labeling in carbohydrate moieties by [3H]NaBH4 and its synthesis by lymphocytes through labeling with [35S]methionine. Native gpL115 adheres to wheat germ lectin-Sepharose and sialidase-treated gpL115 does not adhere, indicating that native gpL115 adheres via clusters of sialic acid residues. When tested on peanut lectin, which shows specificity for the disaccharide Gal beta 1-3GalNAc, gpL115 is nonadherent and sialidase- treated gpL115 is adherent, indicating the presence of the sequence sialic acid-Gal beta 1-3GalNAc, which is characteristic for O-linked (mucin-type, acidic-type) carbohydrates. A surface glycoprotein with all the above characteristics was found on the lymphoblastoid cell line CEM. CEM cells were used as immunogen to generate the monoclonal antibody L10, an IgG1, which binds native and sialidase-treated gpL115 . Sialidase-treatment of gpL115 significantly alters its physical properties, reducing its electrophoretic mobility and changing its behavior on isoelectrofocusing. Cumulatively, these findings indicate that gpL115 , like glycophorin of erythrocytes and GPIb of platelets, is a sialoglyco protein with significant quantities of O-linked carbohydrate. On treatment with limiting sialidase concentrations, gpL115 of normal lymphocytes is transformed into a series of partially desialylated species of decreasing electrophoretic mobility. This finding resembles the situation with lymphocytes of some Wiskott- Aldrich syndrome patients. Lymphocytes of eight Wiskott-Aldrich syndrome patients were found to be deficient in 125I-labeled gpL115 . Lymphocytes from three of these patients displayed an abnormal 125I- component of apparent mol wt 135,000.
The Terminal Portion of the Pulmonary Arterial Tree in People Native to High Altitudes

RADIOGRAPHIC evidence of right ventricular enlargement with bulging of the main pulmonary artery13 and electroveetoreardiographic signs of right ventricular preponderance2' 4-6 are common findings in people born and living at high altitudes. Anatomically, the existence of right ventricular hypertrophy has been demonstrated both in adults7-9 and children.10 Recently, hemodynamic studies have disclosed that these people present, at rest, a mild degree of pulmonary hypertension and increased pulmonary vascular resistance. "-'3 Children below 5 years of age show higher pulmonary pressure values than older children and adults. '3 Furthermore, different from what occurs in normal persons at sea level, the pulmonary pressure increases markedly during exercise.14 The small muscular branches of the pulmonary arterial tree are primarily concerned in determining pulmonary vascular resistance. Therefore, the study of their morphologic eharacteristics is of paramount importance for understanding the genesis and significance of high altitude pulmonary hypertension. This forms the subject of the present report.
Perception of students' intelligence malleability and potential for future success: Unfavourable beliefs towards girls.

BACKGROUND Endorsing an entity theory of intelligence has negative effects on students' academic trajectories. Research focused on students' personal theories of intelligence has shown that girls are more likely than boys to hold an entity theory of intelligence. However, no study has examined the possibility of a gender stereotype basis for this belief. AIMS We examined whether secondary school students are knowledgeable about others' beliefs describing female students' intelligence as less malleable than male students' intelligence. SAMPLE AND METHOD A sample of 85 French ninth graders were asked to rate to what extent others perceived: (1) female or male students' intelligence as malleable and fixed; (2) female or male students as making efforts for their current achievement; and (3) female or male students as having potential for future success. RESULTS Participants reported that others perceived girls' intelligence as less malleable than boys' intelligence. Moreover, the relationship between current efforts and potential for future achievement depended on the target's gender. The more hardworking a female student was perceived to be in school, the less she was considered to have potential to succeed in the future, whereas such a link was not observed for a male student. CONCLUSIONS Secondary school students seem to be knowledgeable about a gender stereotype regarding intelligence and potential for academic success which is unfavourable for female students. Implications for students' academic trajectories are discussed.
CENTRO DE INVESTIGACIÓN ECONÓMICA Discussion Paper Series Financial Market Discipline in Early 20 th Century Mexico Elisabeth Huybens

We test for the presence of market discipline in the banking sector in early 20 century Mexico. Using a panel of financial data from note-issuing banks between 1905 and 1910, we examine whether bank fundamentals influenced the pattern of withdrawals. When we do not control for exit, our estimation suggests that fundamentals were not a significant determinant of depositor behavior. Instead, bank specific fixed effects and systemic risk seem to have been the most important determinants of net changes in deposits. However this period included the banking crisis of 1907, and the subsequent exit of several banks, indicating that a sample selection bias may exist. Our results change substantially when we use a two step estimator to take this bias into account. We show that fundamentals were indeed an important determinant of bank withdrawals in this period, clearly indicating the existence of market discipline. 1 We are grateful to Aditya Goenka, Noel Maurer and participants at the LACLIO 2000 conference at Stanford for helpful comments. The views expressed in this paper are those of the authors and do not necessarily reflect those of the World Bank. The responsibility for all errors is ours. 2 The World Bank, Macroeconomics 3, Africa Region, 1818 H Street NW, Washington D.C. 20433. The author was an assistant professor at the Centro de Investigación Económica, ITAM when this paper was written. email: ehuybens@worldbank.org 3 Department of Economics, University of Essex, Wivenhoe Park, Colchester, CO4, 3SQ, U.K. 4 Corresponding author. Centro de Investigación Económica, Instituto Tecnológico Autónomo de México, Av. Camino Sta. Teresa #930, Mexico D.F. 10700. email: pratap@itam.mx
Basal epithelial stem cells are efficient targets for prostate cancer initiation

Prevailing theories suggest that luminal cells are the origin of prostate cancer because it is histologically defined by basal cell loss and malignant luminal cell expansion. We introduced a series of genetic alterations into prospectively identified populations of murine basal/stem and luminal cells in an in vivo prostate regeneration assay. Stromal induction of FGF signaling, increased expression of the ETS family transcription factor ERG1, and constitutive activation of PI3K signaling were evaluated. Combination of activated PI3K signaling and heightened androgen receptor signaling, which is associated with disease progression to androgen independence, was also performed. Even though luminal cells fail to respond, basal/stem cells demonstrate efficient capacity for cancer initiation and can produce luminal-like disease characteristic of human prostate cancer in multiple models. This finding provides evidence in support of basal epithelial stem cells as one target cell for prostate cancer initiation and demonstrates the propensity of primitive cells for tumorigenesis.
The Role of Host and Microbial Factors in the Pathogenesis of Pneumococcal Bacteraemia Arising from a Single Bacterial Cell Bottleneck

The pathogenesis of bacteraemia after challenge with one million pneumococci of three isogenic variants was investigated. Sequential analyses of blood samples indicated that most episodes of bacteraemia were monoclonal events providing compelling evidence for a single bacterial cell bottleneck at the origin of invasive disease. With respect to host determinants, results identified novel properties of splenic macrophages and a role for neutrophils in early clearance of pneumococci. Concerning microbial factors, whole genome sequencing provided genetic evidence for the clonal origin of the bacteraemia and identified SNPs in distinct sub-units of F0/F1 ATPase in the majority of the ex vivo isolates. When compared to parental organisms of the inoculum, ex-vivo pneumococci with mutant alleles of the F0/F1 ATPase had acquired the capacity to grow at low pH at the cost of the capacity to grow at high pH. Although founded by a single cell, the genotypes of pneumococci in septicaemic mice indicate strong selective pressure for fitness, emphasising the within-host complexity of the pathogenesis of invasive disease.
Kuguacin J, a Triterpenoid from Momordica charantia Linn: A Comprehensive Review of Anticarcinogenic Properties

© 2013 Limtrakul et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Kuguacin J, a Triterpenoid from Momordica charantia Linn: A Comprehensive Review of Anticarcinogenic Properties
Robust Adaptive Beamforming Using Sequential Quadratic Programming: An Iterative Solution to the Mismatch Problem

A new approach to the design of robust adaptive beamforming is introduced. The essence of the new approach is to estimate the difference between the actual and presumed steering vectors and to use this difference to correct the erroneous presumed steering vector. The estimation process is performed iteratively where a quadratic convex optimization problem is solved at each iteration. Contrary to the worst-case performance-based and the probability-constrained-based approaches, our approach does not make any assumptions on either the norm of the mismatch vector or its probability distribution. Hence, it avoids the need for estimating their values.
Contributions of Climatic Factors to Interannual Variability of the Vegetation Index in Northern China Grasslands

Understanding the atmosphere–land surface interaction is crucial for clarifying the responses and feedbacks of terrestrial ecosystems to climate change. However, quantifying the effects of multiple climatic factors to vegetation activities is challenging. Using the geographical detector model (GDM), this study quantifies the relative contributions of climatic factors including precipitation, relative humidity, solar radiation, and air temperature to the interannual variation (IAV) of the normalized difference vegetation index (NDVI) in the northern grasslands of China during 2000 to 2016. The results show heterogeneous spatial patterns of determinant climatic factors on the IAV of NDVI. Precipitation and relative humidity jointly controlled the IAV of NDVI, illustrating more explanatory power than solar radiation and air temperature, and accounting for higher proportion of area as the determinant factor in the study region. It is noteworthy that relative humidity, a proxy of atmospheric aridity, is as important as precipitation for the IAV of NDVI. The contribution of climatic factors to the IAV of NDVI varied by vegetation type. Owing to the stronger explanatory power of climatic factors on NDVI variability in temperate grasslands, we conclude that climate variability may exert more influence on temperate grasslands than on alpine grasslands. Our study highlights the importance of the role of atmospheric aridity to vegetation activities in grasslands. We suggest focusing more on the differences between vegetation types when addressing the climate–vegetation relationships at a regional scale.
Local-Effect Games

We present a new class of games, local-effect games (LEGs), which exploit structure in a different way from other compact game representations studied in AI. We show both theoretically and empirically that these games often (but not always) have pure-strategy Nash equilibria. Finding a potential function is a good technique for finding such equilibria. We give a complete characterization of which LEGs have potential functions and provide the functions in each case; we also show a general case where pure-strategy equilibria exist in the absence of potential functions. In experiments, we show that myopic best-response dynamics converge quickly to pure strategy equilibria in games not covered by our positive theoretical results.
Purification of Clostridium thermocellum xylanase Z expressed in Escherichia coli and identification of the corresponding product in the culture medium of C. thermocellum

An endoxylanase encoded by the xynZ gene of Clostridium thermocellum was purified from Escherichia coli harbouring a fragment of the gene cloned in pUC8. The purified enzyme showed two active bands of Mr 41,000 and 39,000, the latter one presumably derived from the former through proteolysis. The enzyme was highly active on xylan and para-nitrophenyl-beta-D-xylobioside. The major end product of xylan hydrolysis was xylobiose. With an antiserum raised against the enzyme purified from E. coli, an immunoreactive polypeptide of Mr 90,000, corresponding to the entire xynZ gene product, was detected in a culture supernatant from C. thermocellum grown on cellulose. By immunological detection, xylanase Z was shown to be associated with a cellulose-binding, high-molecular-weight fraction whose properties coincided with those described previously for the cellulose-degrading complex of C. thermocellum known as the cellulosome.
Effective assessment of use of sitters by nurses in inpatient care settings.

AIM This paper is a report of the evaluation of the impact of adopting the Patient Attendant Assessment Tool (PAAT) on nurses' requests for sitters, use of restraints, and falls and fall injury rates. BACKGROUND Staffing should be the primary issue in eliminating risks of patient falls during hospital stays. METHOD Data were collected in two acute adult medical units of a Michigan hospital from August 2005 to February 2007. Data from three sources were merged for analyses: (1) study units' monthly reports; (2) quarterly reports of the National Database of Nursing Quality Indicators and (3) PAAT reports collected from October 2006 to February 2007. The primary outcome variables were the use of sitters, number of restraints ordered and fall and fall injury rates. Independent t-tests and correlation analyses were used for data analyses. The data before and after adopting this tool were compared using independent t-tests. FINDINGS The PAAT helped improve the fill/request rates for sitters. The use of soft limb holders decreased after adoption of this tool. The results also showed that if the number of sitter requests was higher, the total number of restraints would be lower but the total fall rate would be higher. CONCLUSION Hospitals should include a tool similar to the PAAT in guidelines related to provision of constant observation or use of sitters. Further investigations of the optimum combination of staffing patterns and infrastructure are needed to promote safer hospital stays.
Identification of a Microtubule-associated Motor Protein Essential for Dendritic Differentiation

The quintessential feature of the dendritic microtubule array is its nonuniform pattern of polarity orientation. During the development of the dendrite, a population of plus end–distal microtubules first appears, and these microtubules are subsequently joined by a population of oppositely oriented microtubules. Studies from our laboratory indicate that the latter microtubules are intercalated within the microtubule array by their specific transport from the cell body of the neuron during a critical stage in development (Sharp, D.J., W. Yu, and P.W. Baas. 1995. J. Cell Biol. 130:93– 104). In addition, we have established that the mitotic motor protein termed CHO1/MKLP1 has the appropriate properties to transport microtubules in this manner (Sharp, D.J., R. Kuriyama, and P.W. Baas. 1996. J. Neurosci. 16:4370–4375). In the present study we have sought to determine whether CHO1/MKLP1 continues to be expressed in terminally postmitotic neurons and whether it is required for the establishment of the dendritic microtubule array. In situ hybridization analyses reveal that CHO1/MKLP1 is expressed in postmitotic cultured rat sympathetic and hippocampal neurons. Immunofluorescence analyses indicate that the motor is absent from axons but is enriched in developing dendrites, where it appears as discrete patches associated with the microtubule array. Treatment of the neurons with antisense oligonucleotides to CHO1/MKLP1 suppresses dendritic differentiation, presumably by inhibiting the establishment of their nonuniform microtubule polarity pattern. We conclude that CHO1/MKLP1 transports microtubules from the cell body into the developing dendrite with their minus ends leading, thereby establishing the nonuniform microtubule polarity pattern of the dendrite.
Obstacles and options in the quest for drug candidates against vascular disease

Summary he difficulties in cardiovascular drug development have been exposed by recent clinical trials, which have uncovered various limitations of promising drug candidates. Yet, the imperative to improve medical treatment of atherosclerosis in aging populations afflicted by metabolic disease remains unbroken. Herein alternatives to metabolically active compounds such as glitazones and torcetrapib are introduced and discussed, namely CC chemokine receptor 5 (CCR5) antagonists recently approved for treatment of patients with human immunodeficiency virus-1, interceptors of proatherogenic chemokine interactions, and actively protective pathways. A combination of different strategies may yield improved safety profiles of these therapeutics.
Discontinuity surfaces and microfacies in a storm‐dominated shallow Epeiric Sea, Devonian Cedar Valley Group, Iowa

Discontinuity surfaces develop in carbonate successions in response to a range of environmental changes and represent an integral part of the stratigraphic record. In Palaeozoic shallow epeiric basins that are typified by extremely slow subsidence and intermittent sedimentation, discontinuity surfaces may represent the majority of the time‐rock record. A depositional and sequence‐stratigraphic model was developed through microfacies analysis and discontinuity surface characterization using three cores in a proximal to distal transect across the Middle to Upper Devonian Iowa Basin. Twelve microfacies are recognized, spanning supratidal to deep subtidal facies tracts. A total of 105 discontinuity surfaces were documented and classified as either submarine omission surfaces, subaerial exposure surfaces or submarine erosional surfaces. Omission surfaces increase in frequency basinward, indicating increased sediment starvation in the offshore direction. Exposure surfaces increase in frequency shoreward, indicating more frequent subaerial exposure in a shallower setting. Erosional surfaces are dominant in the inner and middle ramp and interpreted as the base of storm beds (tempestites); these surfaces are rare in the outer ramp due to its generally deeper setting below storm wave base. Moreover, discontinuity surfaces exhibit systematic groupings stratigraphically (vertically) across the three localities spanning the Devonian carbonate ramp. Zones of either exposure‐dominated, erosion‐dominated or omission‐dominated surfaces were recognized and correlated with their landward or basinward equivalents (along with shifts in major facies belts) and interpreted in a sequence‐stratigraphic context. This study highlights the importance of including a detailed characterization of both depositional facies and non‐depositional discontinuity surfaces in order to better understand the stratigraphic history of a basin. The framework of analysis provided here is particularly useful for marine carbonate strata deposited in epeiric basins, which are especially common in the Palaeozoic and where non‐deposition and erosion occur frequently, but can also be applied to other geological time periods and settings.