Miracle-dz/UniFAR-FTUs huggingface dataset:
Transplantation of cultivated oral mucosal epithelium prepared in fibrin-coated culture dishes.

PURPOSE To compare the clinical results of cultivated oral mucosal epithelial cell sheet transplantation (COMET) of substrate-free sheets with those of COMET of amniotic membrane (AM)-based sheets. METHODS Sixteen eyes receiving COMET of substrate-free sheets (substrate-free group) were studied retrospectively and compared with disease-, age-, and ocular surface status-matched eyes undergoing COMET with AM serving as the substrate (AM group). Each group consisted of six eyes with chemical injury, six with pseudo-ocular cicatricial pemphigoid, two with Stevens-Johnson syndrome, and two with ocular cicatricial pemphigoid. Graft survival rate, best-corrected visual acuity (BCVA), and neovascularization (NV) were assessed. RESULT In all 32 eyes, the entire corneal surface on which the cultivated autologous oral mucosal epithelium sheet had been placed was free of epithelial defects at postoperative day 2. The success rates of COMET at 12 months after surgery were 62.5% in the substrate-free sheet group and 43.8% in the AM group. A Kaplan-Meier curve revealed that the graft survival rate in the substrate-free group was significantly superior to that in the AM group (P = 0.046). Mean postoperative BCVA improved significantly at 1, 3, and 6 months in the substrate-free sheet group, and BCVA was significantly better than that in the AM group at all time points. Postoperative NV improved significantly in the substrate-free group at all time points. CONCLUSIONS A better midterm clinical outcome was achieved with COMET of a substrate-free cell sheet than with COMET of AM as a substrate for treating severe stem cell deficiency.
Lysosomal enzymuria is a feature of hereditary Fanconi syndrome and is related to elevated CI-mannose-6-P-receptor excretion.

BACKGROUND Lysosomal enzymuria is usually considered to be a non-specific marker of renal injury, but little is known about lysosomal enzyme excretion in renal proximal tubular cell disorders such as the renal Fanconi syndrome (FS). We examined excretion of two lysosomal enzymes and the cation-independent mannose-6-phosphate receptor (CI-MPR) in patients with inherited FS. METHODS The lysosomal enzyme cathepsin D was measured by ELISA and isolated by pepstatin-agarose affinity chromatography; N-acetyl-beta-d-glucosaminidase (NAG) was assayed colorimetrically, as was the cytosolic enzyme lactate dehydrogenase (LDH). Cathepsin D, procathepsin D and CI-MPR were also detected by western blotting. No patient had a serum creatinine concentration >170 micromol/L. Soluble CI-MPR, isolated from fetal calf serum and bound to agarose, was used to probe cathepsin D for mannose-6-phosphate (M6P). RESULTS Increased excretion of cathepsin D (mean = 44-fold) and NAG (mean = 12-fold) was found in FS patients: Dent's disease (n = 5), cystinosis (n = 4), Lowe syndrome (n = 3) and 'autosomal dominant idiopathic FS' (ADIF) (n = 2). Increased cathepsin D excretion was confirmed by western blotting; excretion of procathepsin D and LDH was not increased. When compared with control subjects, CI-MPR excretion was also increased in FS (n = 6). Thus, significantly increased excretion of lysosomal enzymes and CI-MPR was found in all cases of FS examined. Cathepsin D binding to CI-MPR-agarose was inhibited by M6P. CONCLUSIONS We conclude that underlying gene defects in FS may disrupt normal membrane trafficking of CI-MPR, leading to mistrafficking of lysosomal enzymes via a default pathway from the Golgi to the apical surface of proximal tubule cells rather than to lysosomes. Lysosomal enzymes are then secreted into the tubular fluid and excreted in the urine. This contrasts with the widely held view that cell necrosis is the cause of lysosomal enzymuria in renal disease. Moreover, cathepsin D in FS urine is M6P-tagged.
Recent developments in S HERPA

In the past decades, event generators such as PYTHIA [1, 2] and HERWIG [3, 4] have been central for nearly all physics analyses at particle physics experiments at the high-energy frontier. This will also hold true at the LHC, where a large number of interesting signals for new particles or new phenomena (the Higgs boson or any other manifestation of the mechanism behind electro-weak symmetry breaking, supersymmetry, extra dimensions etc.) is hampered by a plethora of severe, sometimes overwhelming backgrounds. Nearly all of them are largely influenced by QCD. Therefore it seems fair to say that the success of the LHC in finding new physics may very well depend on a deep and detailed understanding of old physics, like QCD. Examples for this include, among others, the central-jet veto for the vector boson fusion channel for Higgs production or topologies, where gauge bosons emerge in association with many jets, a background for many search channels. In a reflection on increased needs by the experimental community, aiming at higher precision, incorporation of new physics models and so on, the work horses of old have undergone serious renovation efforts, resulting in new, improved versions of the respective codes, namely PYTHIA8 [5] and HERWIG++ [6]. In addition a completely new code, SHERPA [7], has been constructed and is in the process of maturing. The status of this code is the topic of this contribution. SHERPA’s hallmark property is the inclusion of higher-order tree-level QCD contributions, leading to an improved modelling of jet production. They are introduced through a fullfledged matrix element generator, AMEGIC++ [8], which is capable of generating matrix elements and corresponding phase space mappings for processes with multi-particle final states in various models, including the Standard Model, anomalous gauge triple and quadruple couplings according to [9, 10], the Minimal Supersymmetric Standard Model with Feynman rules from [11], the ADD-model of extra dimensions [12, 13], and a model with an extra U(1) singlet coupling to the Higgs boson only [14]. The code has been thoroughly tested and validated [15]. This code, however, is limited, especially in the treatment of many (≥ 6) external QCD particles. Therefore, in the near future, SHERPA will incorporate another, new matrix element generator, COMIX, which is based on Berends-Giele recursion relations [16] and colour-dressing [17] rather than colour-ordering. In Tabs. 1 and 2 some example cross sections for gg → ng at fixed energies and pp → bb̄+n jets obtained with this program are exhibited and compared to those from other programs.
Flickr and public image-sharing: distant closeness and photo exhibition

This paper presents an empirical study in progress of the use of Flickr.com, part of an on-going research program on personal digital media, including images. Two new kinds of image-sharing with Flickr are.distant closeness. and.photo exhibition. We are seeing changing uses of images in social interaction and increased multi-modal communication.
Western of Emergency Medicine: Integrating Emergency Care with Population Health Nonreciprocal and Reciprocal Dating Violence and Injury Occurrence among Urban Youth

Objective: Dating violence is a significant health problem among youth that leads to adverse health outcomes, including injuries. Reciprocal violence (perpetrated by both partners) is associated with increased injury in adults, but very little is known about the prevalence and context for reciprocal violence, as well as injury rates, among youth. We sought to determine the prevalence and scope of reciprocal dating violence and injury occurrence among urban youth in a high-risk community. Methods: Analyses were based on data from the Youth Violence Survey, conducted in 2004, and administered to over 80% of public school students in grades 7, 9, 11, and 12 (N=4,131) in a high-risk, urban school district. The current analyses were restricted to those who reported dating in the past year and who also reported any dating violence (n=1,158). Dating violence was categorized as reciprocal (the participant reported both violence perpetration and victimization) and non-reciprocal (the participant report either violence perpetration or victimization, but not both). Results: Dating violence reciprocity varied by sex. Girls who reported any dating violence were more likely to report reciprocal dating violence (50.4%) than were boys (38.9%). However, reciprocity did not vary by race/ethnicity or grade level. Reciprocal dating violence was more common among participants who reported more frequent violence experiences. Reciprocal violence was also associated with greater injury occurrences relative to non-reciprocal relationships (10.1% versus 1.2%). Conclusion: Reciprocal dating violence is common among adolescents and leads more often to injury outcomes. In particular, relationships in which boys report reciprocal violence against their partner appear to lead to more frequent injury occurrences. These findings underscore the importance of addressing dating violence and factors that increase risk for reciprocal violence and therefore exacerbate injury occurrence. [West J Emerg Med. 2010; 11(3): 264-268. ]
Interpretation of porosity and LWD resistivity from the Nankai accretionary wedge in light of clay physicochemical properties: Evidence for erosion and local overpressuring

In this study, we used porosity to assess the compaction state of the Nankai accretionary wedge sediments and any implications for stress and pore pressure. However, hydrous minerals affect porosity measurements, and accounting for them is essential toward defining the interstitial porosity truly representative of the compaction state. The water content of sediments was measured in core samples and estimated from logging data using a resistivity model for shale. We used the cation exchange capacity to correct the porosity data for the amount of water bound to clay minerals and to correct the porosity estimates for the surface conductivity of hydrous minerals. The results indicate that several apparent porosity anomalies are significantly reduced by this correction, implying that they are in part artifacts from hydrous minerals. The correction also improves the fit of porosity estimated from logging‐while‐drilling (LWD) resistivity data to porosity measured on cores. Low overall porosities at the toe of the accretionary wedge and in the splay fault area are best explained by erosion, and we estimated the quantity of sediments eroded within the splay fault area by comparing porosity‐effective stress relationships of the sediments to a reference curve. Additionally, a comparison of LWD data with core data (resistivity and P wave velocity) obtained at Site C0001 landward of the mega‐splay fault area, suggested a contribution from the fracture porosity to in situ properties on the formation.
Effects on the quality of the nursing care process through an educational program and the use of electronic nursing documentation.

PURPOSE To evaluate the effect of the educational program "Guided Clinical Reasoning" (GCR) and the introduction of an intelligent electronic nursing documentation system (e-doc) on the quality of the nursing process. METHODS Evaluation was conducted at three measurement points and rated with the instrument "Quality of Nursing Diagnoses, Interventions and Outcomes" (Q-DIO). FINDINGS GCR showed the best Q-DIO-scores. No long-term effect was found after GCR cessation. The e-doc delivered the lowest scores, while showing adequate support in using nursing diagnoses. CONCLUSIONS E-docs can support conducting the nursing process, but for meaningful e-doc use, clinical reasoning is essential. IMPLICATIONS High-quality nursing documentation requires recognition of factors obstructing or supporting nurses in the use of e-docs while conducting the nursing process.
Tableau methods of proof for modal logics

1 Introduction: In [1] Fitch proposed a new proof proceedure for several standard modal logics. The chief characteristic of this was the inclusion in the object language, of symbols representing worlds in Kripke models. In this paper we incorporate the device into a tableau proof system and it is seen that the resulting (propositional) proof system is highly analogous to a classical first order tableau system, with the modal operators behaving like quantifiers. Exploiting this similarity, a tableau completeness proof for first order logic directly becomes a Kripke completeness proof for modal logic, and Smullyan's fundamental theorem of quantification theory (a Herbrand-like theorem) [7] has its analog. Indeed, more than analogy is at work here; from an appropriate abstract point of view certain modal logics, first order classical and intuitionistic logic, and various infinitary logics may be treated simultaneously, an approach due to R. Smullyan and developed in a forthcoming monograph (see [8] for a preliminary version). We will treat only tableau proof systems and some familiarity with [7] is presumed. In addition to being metatheoretically interesting, specific tableau systems we give for S5, S4, T, B, DS4, DT, and K are quite simple to use. The extension of these systems to first order systems is straightforward , and is discussed briefly in the last section.
Serine Protease Inhibitors in Ticks: An Overview of Their Role in Tick Biology and Tick-Borne Pathogen Transmission

New tick and tick-borne pathogen control approaches that are both environmentally sustainable and which provide broad protection are urgently needed. Their development, however, will rely on a greater understanding of tick biology, tick-pathogen, and tick-host interactions. The recent advances in new generation technologies to study genomes, transcriptomes, and proteomes has resulted in a plethora of tick biomacromolecular studies. Among these, many enzyme inhibitors have been described, notably serine protease inhibitors (SPIs), whose importance in various tick biological processes is only just beginning to be fully appreciated. Among the multiple active substances secreted during tick feeding, SPIs have been shown to be directly involved in regulation of inflammation, blood clotting, wound healing, vasoconstriction and the modulation of host defense mechanisms. In light of these activities, several SPIs were examined and were experimentally confirmed to facilitate tick pathogen transmission. In addition, to prevent coagulation of the ingested blood meal within the tick alimentary canal, SPIs are also involved in blood digestion and nutrient extraction from the meal. The presence of SPIs in tick hemocytes and their involvement in tick innate immune defenses have also been demonstrated, as well as their implication in hemolymph coagulation and egg development. Considering the involvement of SPIs in multiple crucial aspects of tick-host-pathogen interactions, as well as in various aspects of the tick parasitic lifestyle, these molecules represent highly suitable and attractive targets for the development of effective tick control strategies. Here we review the current knowledge regarding this class of inhibitors in tick biology and tick-borne pathogen transmission, and their potential as targets for future tick control trials.
Preneoplastic antigen as a marker for endoplasmic reticulum of putative premalignant hepatocytes during liver carcinogenesis.

Further study of the subcellular localization of a preneoplastic antigen in hyperplastic liver nodules and primary hepatocellular carcinoma induced in rats by acetylaminofluorene has been pursued. Antisera against four subcellular fractions, cytosol, smooth and rough endoplasmic reticulum, and free polysomes, were obtained in rabbits and were used to assay for the presence of the antigen by immunodiffusion. The preneoplastic antigen, Antigen 1, appearing as a sharp precipitin line, is located predominantly, if not exclusively, in the smooth endoplasmic reticulum fraction of hyperplastic nodules and hepatomas. It appears after about 3 weeks of 2-acetylaminofluorene feeding and persists throughout the carcinogenic process in nodules and hepatomas. A second antigen, antigen 2, appears in the smooth endoplasmic reticulum of nodules after 13 weeks of 2-acetylaminofluorene feeding but gradually disappears on discontinuation of exposure to the carcinogen after 20 weeks. This antigen, appearing as a more diffuse precipitin line, becomes demonstrable in rough endoplasmic reticulum as well but only after stripping off the ribosomes. The presence and distribution of preneoplastic antigen during carcinogenesis as revealed by immunodiffusion was similar when a more sensitive assay, microcomplement fixation, was used. The preneoplastic antigen appears to be a potentially useful marker for alterations in the smooth endoplasmic reticulum that may be related to the development of liver cancer.
Iso-seco-tanapartholides: Isolation, Synthesis and Biological Evaluation

The isolation, identification and total synthesis of two plant-derived inhibitors of the NF-κB signaling pathway from the iso-seco-tanapartholide family of natural products is described. A key step in the efficient reaction sequence is a late-stage oxidative cleavage reaction that was carried out in the absence of protecting groups to give the natural products directly. A detailed comparison of the synthetic material with samples of the natural products proved informative. Biological studies on synthetic material confirmed that these compounds act late in the NF-κB signaling pathway. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Psychotropic medication use in children and adolescents: a study from France.

OBJECTIVE In Europe, little information exists on the pediatric use of psychotropic medication. This study aimed to describe the extent and patterns of psychotropic medication use in children and adolescents enrolled in a large health plan (MGEN) in France, and its evolution in recent years. METHODS MGEN affiliates aged 0 to 17 years were randomly selected at the end of three consecutive years, 2003 (n = 6534), 2004 (n = 6625), and 2005 (n = 6704). Reimbursement claims were organized into three 1-year cross-sectional data sets. Results are detailed for the year 2003 only. RESULTS In 2003, psychotropic medication, principally anxiolytics and hypnotics, concerned 3.3% of children and adolescents, of whom 35.0% used only herbal drugs. General practitioners were found to be behind most of these prescriptions (63.5%) and, worryingly, 15.1% were drugs restricted to adult use. Nevertheless, most psychotropic medication users (71.0%) had only one prescription. In general, psychotropic medication users received a relatively good medical follow-up. Similar results were found for the years 2004 and 2005. CONCLUSION No increasing trend in prevalence was found. However, a subject for concern is the proportion of psychotropic drugs with no market authorization for pediatric use that were prescribed to young patients.
Post-mortem MRI-guided sampling of multiple sclerosis brain lesions: increased yield of active demyelinating and (p)reactive lesions.

Macroscopic sampling of multiple sclerosis lesions in the brain tends to find chronic lesions. For a better understanding of the dynamics of the multiple sclerosis disease process, research into new and developing lesions is of great interest. As MRI in vivo effectively demonstrates lesions in multiple sclerosis patients, we have applied it to unfixed post-mortem brain slices to identify abnormalities, in order to obtain a higher yield of active lesions. The Netherlands Brain Bank organized the rapid autopsy of 29 multiple sclerosis patients. The brain was cut in 1 cm coronal slices. One or two slices were subjected to T(1)- and T(2)-weighted MRI, and then cut at the plane of the MRI scan into 5 mm thick opposing sections. Areas of interest were identified based on the MRI findings and excised. One half was fixed in 10% formalin and paraffin-embedded, and the corresponding area in the adjacent half was snap-frozen in liquid nitrogen. In total, 136 out of 174 brain tissue samples could be matched with the abnormalities seen on T(2)-weighted MRIs. The stage of lesional development was determined (immuno) histochemically. For 54 MRI-detectable samples, it was recorded whether they were macroscopically detectable, i.e. visible and/or palpable. Histopathological analysis revealed that 48% of the hyperintense areas seen on T(2)-weighted images represented active lesions, including lesions localized in the normal appearing white matter, without apparent loss of myelin but nevertheless showing a variable degree of oedema, small clusters of microglial cells with enhanced major histocompatibility complex class II antigen, CD45 and CD68 antigen expression and a variable number of perivascular lymphocytes around small blood vessels [designated as (p)reactive lesions]. From the macroscopically not-visible/not-palpable MRI-detected abnormalities, 58% were (p)reactive lesions and 21% contained active demyelinating lesions. In contrast, visible and/or palpable brain tissue samples mainly contained chronic inactive lesions. We conclude that MRI-guided sampling of brain tissue increases the yield of active multiple sclerosis lesions, including active demyelinating and (p)reactive lesions.
Effect of Intimate Partner Violence on Antenatal Functional Health Status of Childbearing Women in Northeastern Thailand

We investigated the effects of physical, psychological, and sexual violence on the health status of women attending antenatal clinics at two tertiary hospitals in rural Thailand. We asked 421 pregnant women at 32 weeks gestation or later to complete a survey questionnaire. Participants reported high rates of psychological abuse (53.7%); threats, acts of physical abuse, or both (26.6%); and sexual violence (19.2%). Women abused during pregnancy had poorer health compared with nonabused women, in role emotional functioning, vitality, bodily pain, mental health, and social functioning. Given the high prevalence of violence and poor health status, routine screenings by maternity services is urgently required.
Friction stir spot welding of AA 1050 Al alloy and hot stamped boron steel (22MnB5)

The present study investigates the effect of joining parameters on the microstructural and mechanical characteristics of dissimilar friction stir spot welding (FSSW) between AA 1050 Al and 22MnB5 hot stamped boron steel. Mechanical performance has been evaluated by shear and microhardness testing. Optical microscopy has been used to investigate the microstructure generated in the different FSSW regions. A macrostructural examination has revealed the creation of mechanical interlocking in the Al steel connections. No volumetric defects or any other imperfection has been found in all FSSW connections. Shear failure load has increased with increasing both tool rotational speed and plunge depth for all FSSW connections. Higher plunge depth has improved the mechanical interlocking between lower and upper sheet due to the formation of a larger secondary flash. Encouraging results have been obtained using coated WC–Co tools in terms of durability and joint performance.
14.6 A 1.42TOPS/W deep convolutional neural network recognition processor for intelligent IoE systems

In this paper, we present an energy-efficient CNN processor with 4 key features: (1) a CNN-optimized neuron processing engine (NPE), (2) a dual-range multiplyaccumulate (DRMAC) block for low-power convolution operations, (3) an on-chip memory architecture and a utilization scheme for reducing off-chip memory accesses, (4) kernel data compression for further reducing off-chip memory accesses.