Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomarkers for Basal-like Breast Cancer

Initially recognized through microarray-based gene expression profiling, basal-like breast cancer, for which we lack effective targeted therapies, is an aggressive form of carcinoma with a predilection for younger women. With some success, immunohistochemical studies have attempted to reproduce the expression profile classification of breast cancer through identification of subtype-specific biomarkers. This review aims to present an in depth summary and analysis of the current status of basal-like breast cancer biomarker research. While a number of biomarkers show promise for future clinical application, the next logical step is a comprehensive investigation of all biomarkers against a gene expression profile gold standard for breast cancer subtype assignment.
The Demand for M1 in the USA: A Reply

Using general to simple methods, J. M. Boughton (1993) develops an econometric model that fits almost as well as Y. Baba, D. F. Hendry, and R. M. Starr (BHS) (1992) but differs in economic implications and dynamic adjustments. He claims the new model is constant, is not encompassed by BHS, but does not encompass BHS. He concludes that the new variables in BHS do not matter for fit or constancy. The authors replicate Boughton's findings but their simplification encompassing test confirms the importance of the novel variables in BHS and shows that BHS encompasses his model. An explanation is offered for its constancy when previous studies suffered predictive failure. Copyright 1993 by Royal Economic Society.
Cellular uptake mechanism and intracellular fate of hydrophobically modified pullulan nanoparticles

The cellular uptake mechanism and intracellular fate of self-assembled nanoparticles (NPs) of cholesterol-modified pullulan (CHSP) by human hepatocellular carcinoma (HepG2) cells were investigated. Covalent conjugation with fluorescein isothiocyanate (FITC) yielded stably labeled CHSP (FITC-CHSP), which was successfully formulated into NPs (mean particle size 63.0 ± 1.9 nm) by dialysis. A cytotoxicity assay clearly indicated that the CHSP NPs did not show significant toxicity in HepG2 cells. The effects of NP concentration, incubation time, and temperature on the cellular uptake of the NPs were systematically evaluated by fluorometry, and the results suggested that cellular uptake of the NPs was concentration-,time-, and temperature-dependent. In vitro experiments with endocytic inhibitors revealed that clathrin-mediated endocytosis and macropinocytosis were involved in the internalization of CHSP NPs. The intracellular trafficking study demonstrated that CHSP NPs were entrapped in the lysosomes at 1 hour after incubation; colocalization of NPs with either the Golgi apparatus or the endoplasmic reticula was not observed during the entire course of the study. These results suggested that the CHSP NPs may serve as a versatile carrier for intracellular delivery of therapeutic agents.
The Lively Arts as Substitutes for the Lively Arts

The notion that the price of substitutes serves as a determinant of lively arts demand is hardly new. It dates back decades at least to the seminal work by William Baumol and William Bowen (1966, p. 244), who contended that movies substitute for live performances. Susan Touchstone (1980, p. 36), examining lively arts demand in the United States, followed the lead of Baumol and Bowen by defining substitute price in terms of movie admission, while Glenn Withers (1980, p. 739), also for the United States, cast it in terms of reading or recreation. I (1984, p. 462) considered both types of measures in connection with a study of the demand for Shakespeare in Great Britain. But surely if movies or reading or recreation are substitutes for the lively arts, then so are those arts themselves. Should Richard II become dearer, an individual might elect to attend La Boheme or Fidelio or Swan Lake rather than to sit through "Superman II. " The lively arts are not homogeneous. Each has its own set of characteristics, and consequently substitutes lie within the arts spectrum. Apart from fleeting acknowledgment by, say, Alan Peacock (1981, p. 3), this point has been ignored by demand analyses to date. It is not ignored here.
Clinical Implications of the Cervical Papanicolaou Test Results in the Management of Anal Warts in HIV-Infected Women

The Papanicolaou test (or Pap test) has long been used as a screening tool to detect cervical precancerous/cancerous lesions. However, studies on the use of this test to predict both the presence and change in size of genital warts are limited. We examined whether cervical Papanicolaou test results are associated with the size of the largest anal wart over time in HIV-infected women in an on-going cohort study in the US. A sample of 976 HIV-infected women included in a public dataset obtained from the Women’s Interagency HIV Study (WIHS) was selected for analysis. A linear mixed model was performed to determine the relationship between the size of anal warts and cervical Pap test results. About 32% of participants had abnormal cervical Pap test results at baseline. In the adjusted model, a woman with a result of Atypia Squamous Cell Undetermined Significance/Low-grade Squamous Intraepithelial Lesion (ASCUS/LSIL) had an anal wart, on average, 12.81 mm2 larger than a woman with normal cervical cytology. The growth rate of the largest anal wart after each visit in a woman with ASCUS/LSIL was 1.56 mm2 slower than that of a woman with normal cervical results. However, they were not significant (P = 0.54 and P = 0.82, respectively). This is the first study to examine the relationship between cervical Pap test results and anal wart development in HIV-infected women. Even though no association between the size of anal wart and cervical Pap test results was found, a screening program using anal cytology testing in HIV-infected women should be considered. Further studies in cost-effectiveness and efficacy of an anal cytology test screening program are warranted.
Downregulation of Endothelin-1 by Farnesoid X Receptor in Vascular Endothelial Cells

The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that is highly expressed in liver, kidney, adrenals, and intestine. FXR may play an important role in the pathogenesis of cardiovascular diseases via regulating the metabolism and transport of cholesterol. In this study, we report that FXR is also expressed in rat pulmonary artery endothelial cells (EC), a “nonclassical” bile acid target tissue. FXR is functional in EC, as demonstrated by induction of its target genes such as small heterodimer partner (SHP) after treatment with chenodeoxycholic acid, a FXR agonist. Interestingly, activation of FXR in EC led to downregulation of endothelin (ET)-1 expression. Reporter assays showed that activation of FXR inhibited transcriptional activation of the human ET-1 gene promoter and also repressed the activity of a heterologous promoter driven by activator protein (AP)-1 response elements. Electrophoretic mobility-shift and chromatin immunoprecipitation assays indicated that FXR reduced the binding activity of AP-1 transcriptional factors, suggesting that FXR may suppress ET-1 expression via negatively interfering with AP-1 signaling. These studies suggest that FXR may play a role in endothelial homeostasis and may serve as a novel molecular target for manipulating ET-1 expression in vascular EC.
Automatic Rooftop Detection Using a Two-Stage Classification

This paper presents a novel application of machine learning techniques to the automatic detection of building rooftops in satellite images. The image is first segmented into homogeneous regions using the k-means algorithm. These segments are then treated as candidate rooftop regions which are presented to a novel two-stage classification process, features are extracted from each segment and submitted to an ANN which serves as the first stage of the classification procedure. New features are then extracted from the outputs of the ANN and these are presented to an SVM which then performs the second classification pass. In this way, the first classification stage acts as a preprocessing step which, when processed by the SVM significantly reduces the number of false-positives. To establish the efficacy of the proposed method, its results are compared with those obtained using an alternative approach.
Factors That Influence Male Millennials to Become Professional Librarians

approved: ________________________________________________________ Dr. Gwen Alexander, Co-Chair Dr. Mirah Dow, Co-Chair This case study investigates what prompts male Millennials to join the historically stereotyped feminized library profession. The study addresses social, cultural, economic, and/or political factors that influence male Millennials to become professional librarians; the influence of technology on male Millennials currently enrolled in library and information science (LIS) graduate programs decisions to become professional librarians; and professional stereotypes male Millennials currently enrolled in LIS graduate programs encounter. To gather data, surveys were conducted with 231 participants enrolled in 37 LIS graduate programs across the United States, and semi-structured interviews were conducted with 21 volunteers who participated in the surveys. Findings have implications for LIS graduate program recruitment and retention practices and suggest extending the scope of literature in the areas of professional librarianship and gender roles.
Complexity in local government change

Abstract This article discusses empirical research findings indicating that complexity is a dominant characteristic in local government change and addresses that the current complexity sets limits to rational reform processes and gives way to political leadership. During the recent decade, intermunicipal co-operation has emerged as a major issue in local governance in Finland. Despite the fact that the need for intense co-operation is acknowledged in most surveys, practical steps are often difficult to take due to complexity of the interorganizational action. Actors come upon complex situations involving many issues; situations where the issues are continuously changing and complicatedly interdependent. Circumstances are further blurred by the fact that actors often hide their preferences. In the changing local governance, complexity, paradoxes and uncertainty decrease the prospective of managerial and expert knowledge, because rational calculations do not give definitive support for decision making. From this perspective, we have reached the limits of rational, clear-cut reforming. More than before, the implementation of change depends on the emergence of political leaders willing and able to take responsibility for reforms.
Lower Third Premolar Rotation in the Krapina Dental Sample

This paper presents some new observations on the Krapina Neandertal dental sample. A number of lower third premolars from this site are rotated in comparison to their expected position relative to the other teeth. We developed a method for accurately describing the rotation for teeth, whether they are in mandibles, included in dental sets or isolated. We compare the frequencies of rotated P3s in the Krapina sample with those observed in a modern human population and in the available Neandertal population specimens. It appears that the two latter have comparable frequencies of P3 rotation whereas rotations found in the Krapina sample have a much higher frequency, whether in relation to the total number of teeth or the number of individuals. Bootstrapping in the comparative samples shows that the probabilities of finding the frequencies of rotated P3s observed at Krapina within the modern and Neandertal lineage groups are very low, below the significance threshold. The Krapina sample thus appears to be unique in its proportion of rotated P3s. After rejecting a mechanical hypothesis (i. e. lack of space) for explaining this condition, we propose a genetic origin for this condition. We discuss the implications of related individuals utilizing the cave over a long period of time.
IMPACT ANALYSIS OF CAR-RELATED TAXES ON FUEL CONSUMPTION IN JAPAN

This article presents an analysis of the impact of car-related taxes in Japan from the viewpoint of their impact on transportation policy goals, revenue generation and controlling transportation demand. They account for about 10 percent of all taxes raised and include taxes on buying cars, regular ownership and usage taxes, and fuel taxes. The authors developed a model of car usage by household to determine how taxes affect car ownership and use and how and if tax subsidies affect transit ridership. Similar research has been one in the EU and the U.S. One key element in Japan is the high share of rail transit, as much as 45 percent of commuter trips in Tokyo and nationwide averaging more than 30 percent of commuter trips. The model studied fuel consumption as a factor of car ownership, use and travel speed. Given current trends, fuel consumption is expected to rise 41 percent by 2010. The study sought to understand which car-related taxes would best reduce this growth in fuel consumption. It found that a fuel tax is more efficient than acquisition or ownership taxes, subsidies for mass transit work, incentives for manufacturers to improve fuel efficiency might work, but taxes are limited in how much they can reduce fuel use.
Mutation Testing from Probabilistic Finite State Machines

Mutation testing traditionally involves mutating a program in order to produce a set of mutants and using these mutants in order to either estimate the effectiveness of a test suite or to drive test generation. Recently, however, this approach has been applied to specifications such as those written as finite state machines. This paper extends mutation testing to finite state machine models in which transitions have associated probabilities. The paper describes several ways of mutating a probabilistic finite state machine (PFSM) and shows how test sequences that distinguish between a PFSM and its mutants can be generated. Testing then involves applying each test sequence multiple times, observing the resultant output sequences and using results from statistical sampling theory in order to compare the observed frequency of each output sequence with that expected.
Isolation and Genomic Characterization of ‘Desulfuromonas soudanensis WTL’, a Metal- and Electrode-Respiring Bacterium from Anoxic Deep Subsurface Brine

Reaching a depth of 713 m below the surface, the Soudan Underground Iron Mine (Soudan, Minnesota, USA) transects a massive Archaean (2.7 Ga) banded iron formation, providing a remarkably accessible window into the terrestrial deep biosphere. Despite carbon limitation, metal-reducing microbial communities are present in potentially ancient anoxic brines continuously emanating from exploratory boreholes on Level 27. Using graphite electrodes deposited in situ as bait, we enriched and isolated a novel halophilic iron-reducing Deltaproteobacterium, Desul-furomonas soudanensis strain WTL, from an acetate-fed three-electrode bioreactor poised at +0.24 V (vs. standard hydrogen electrode). Cyclic voltammetry revealed that D. soudanensis releases electrons at redox potentials approximately 100 mV more positive than the model freshwater surface isolate Geobacter sulfurreducens, suggesting that its extracellular respiration is tuned for higher potential electron acceptors. D. soudanensis contains a 3,958,620-bp circular genome, assembled to completion using single-molecule real-time (SMRT) sequencing reads, which encodes a complete TCA cycle, 38 putative multiheme c-type cytochromes, one of which contains 69 heme-binding motifs, and a LuxI/LuxR quorum sensing cassette that produces an unidentified N-acyl homoserine lactone. Another cytochrome is predicted to lie within a putative prophage, suggesting that horizontal transfer of respiratory proteins plays a role in respiratory flexibility among metal reducers. Isolation of D. soudanensis underscores the utility of electrode-based approaches for enriching rare metal reducers from a wide range of habitats.
The Roles of Earnings and Book Value in Equity Valuation: A Real Options Based Analysis

Employing a real options based valuation model, this paper examines the valuation roles of earnings and book value and cross-sectional differences in valuation properties. Consistent with theoretical predictions, we find that (i) as profitability increases, the value impact of earnings increases whereas that of book value decreases and eventually becomes negative; (ii) the explanatory power of earnings increases, and that of book value decreases, monotonically with profitability, with the two accounting measures behaving as valuation substitutes within a certain intermediate-profitability range; (iii) the P/B ratio increases with both profitability and growth opportunity, whereas P/E behaves in a non-monotonic fashion. Implications are discussed for value-relevance research.
Individual Object Change Detection for Monitoring the Impact of a Forest Pathogen on a Hardwood Forest

Sudden oak death (SOD) has caused widespread mortality in a number of tree and shrub species throughout coastal California. As a result, canopy changes are directly visible from remotely sensed imagery. To quantify changes in horizontal canopy structure to the oak woodlands in China Camp State Park, California, USA, a heavily hit area, we developed a novel change detection technique that tracks changes to individual objects. Using 4-band, 1 m spatial resolution aerial photography, we classified four annual images (2000 to 2003) with object-based image analysis (OBIA) and employed a GIS for our change detection technique. We identified 352 gaps that contained SOD mortality in 2000 and persisted through 2003. Their median areas and perimeters did not change significantly in that time. However, those gaps that increased in size tended to be smaller than those that decreased, indicating increased mortality in newly infected areas. Our new change detection method allowed us to monitor these gaps one-by-one, revealing ecologically meaningful results that would otherwise be obscured in a landscape-scale analysis.
Influence of a postural change of the swimmer's head in hydrodynamic performances using 3D CFD

This study deals with recent researches undertaken by the authors in the field of hydrodynamics of human swimming. The aim of this numerical study was to investigate the flow around the entire swimmer's body. The results presented in this article focus on the combination of a 3D computational fluid dynamics code and the use of the k–ω turbulence model, in the range of Reynolds numbers representative of a swimming level varying from national to international competition. Emphasis is placed on the influence of a postural change of the swimmer's head in hydrodynamic performances, which is directly related to the reduction of overall drag. These results confirm and complete those, less accurate, of a preliminary 2D study recently published by the authors and allow the authors to optimise the swimmer's head position in underwater swimming.
Systematic Review and Meta-analysis of Chiropractic Care and Cervical Artery Dissection: No Evidence for Causation

Background Case reports and case control studies have suggested an association between chiropractic neck manipulation and cervical artery dissection (CAD), but a causal relationship has not been established. We evaluated the evidence related to this topic by performing a systematic review and meta-analysis of published data on chiropractic manipulation and CAD. Methods Search terms were entered into standard search engines in a systematic fashion. The articles were reviewed by study authors, graded independently for class of evidence, and combined in a meta-analysis. The total body of evidence was evaluated according to GRADE criteria. Results Our search yielded 253 articles. We identified two class II and four class III studies. There were no discrepancies among article ratings (i.e., kappa=1). The meta-analysis revealed a small association between chiropractic care and dissection (OR 1.74, 95% CI 1.26-2.41). The quality of the body of evidence according to GRADE criteria was “very low. ” Conclusions The quality of the published literature on the relationship between chiropractic manipulation and CAD is very low. Our analysis shows a small association between chiropractic neck manipulation and cervical artery dissection. This relationship may be explained by the high risk of bias and confounding in the available studies, and in particular by the known association of neck pain with CAD and with chiropractic manipulation. There is no convincing evidence to support a causal link between chiropractic manipulation and CAD. Belief in a causal link may have significant negative consequences such as numerous episodes of litigation.
Asthma-chronic obstructive pulmonary disease overlap syndrome in Poland. Findings of an epidemiological study

Introduction Recent years have seen an increased interest in asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). Aim In 2012, Takeda Polska conducted a non-interventional epidemiological study aimed at identifying the typical phenotype of ACOS patients receiving pulmonary care. Material and methods The study enrolled a total of 12,103 of smoking patients above 45 years of age (mean age: 61.5 years; mean duration of smoking: 28.4 pack-years). A total of 68.6% of patients represented the frequent-exacerbation phenotype (mean number of exacerbations during 12 months: 2.11), and 56.4% of patients from the group comprising 12,103 participants were hospitalized at least once during their lifetime due to a respiratory system disease (mean number: 3.82 ±3.76). Results The most commonly found asthma symptoms included paroxysmal dyspnoea with wheezing, and good response to inhaled steroids. The most frequently identified COPD-associated symptoms were: long-lasting reduction in forced expiratory volume in 1 s (FEV1) (< 80% after administering a bronchodilator) and chronic productive cough. Eighty-five percent of patients were diagnosed with concomitant diseases, predominantly arterial hypertension (62.9%) and metabolic diseases (metabolic syndrome, obesity, type 2 diabetes – 46.4% in total). Conclusions A clinically severe course of ACOS and the presence of concomitant diseases should be regarded as factors justifying an individual selection of inhalation therapy which specifically takes into account anti-inflammatory treatment and patient safety.
Does permanent income hypothesis hold for some selected African countries? Empirical evidence

This paper empirically examines the validity of the Permanent Income Hypothesis for six developing African countries: Cameroon, Ghana, Kenya, Nigeria, Senegal, and South Africa. The study uses the modified Dickey-Fuller unit root (GLS) test to determine stationarity of real income and consumption. It also applies Gregory and Hansen (1996) test for cointegration, and Phillips and Hansen (1990) fully modified OLS (FMOLS) procedure for the estimation of their long-run relationship. The results show that the Permanent Income Hypothesis holds in five of the six countries. One of the policy implications is that only permanent fiscal or monetary policy change will have a permanent impact on spending and aggregate demand in five of the six countries. Discretionary policies which impact real income and credit rationing within these economies will have economic stabilization implications, especially for aggregate spending and economic growth, depending on how temporary or permanent the people view the policies.