Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship between Intrinsic Couplings of the Visual Word Form Area with Spoken Language Network and Reading Ability in Children and Adults

Reading plays a key role in education and communication in modern society. Learning to read establishes the connections between the visual word form area (VWFA) and language areas responsible for speech processing. Using resting-state functional connectivity (RSFC) and Granger Causality Analysis (GCA) methods, the current developmental study aimed to identify the difference in the relationship between the connections of VWFA-language areas and reading performance in both adults and children. The results showed that: (1) the spontaneous connectivity between VWFA and the spoken language areas, i.e., the left inferior frontal gyrus/supramarginal gyrus (LIFG/LSMG), was stronger in adults compared with children; (2) the spontaneous functional patterns of connectivity between VWFA and language network were negatively correlated with reading ability in adults but not in children; (3) the causal influence from LIFG to VWFA was negatively correlated with reading ability only in adults but not in children; (4) the RSFCs between left posterior middle frontal gyrus (LpMFG) and VWFA/LIFG were positively correlated with reading ability in both adults and children; and (5) the causal influence from LIFG to LSMG was positively correlated with reading ability in both groups. These findings provide insights into the relationship between VWFA and the language network for reading, and the role of the unique features of Chinese in the neural circuits of reading.
Suppression of Human Liver Cancer Cell Migration and Invasion via the GABAA Receptor

Objective To investigate the roles of the γ-aminobutyric acid (GABA) in the metastasis of hepatocellular carcinoma (HCC) and to explore the potential of a novel therapeutic approach for the treatment of HCC. Methods The expression levels of GABA receptor subunit genes in various HCC cell lines and patients‘ tissues were detected by quantitative real-time polymerase chain reaction and Western blot analysis. Transwell cell migration and invasion assays were carried out for functional analysis. The effects of GABA on liver cancer cell cytoskeletal were determined by immunofluorescence staining. And the effects of GABA on HCC metastasis in nude mice were evaluated using an in vivo orthotopic model of liver cancer. Results The mRNA level of GABA receptor subunits varied between the primary hepatocellular carcinoma tissue and the adjacent non-tumor liver tissue. GABA inhibited human liver cancer cell migration and invasion via the ionotropic GABAA receptor as a result of the induction of liver cancer cell cytoskeletal reorganization. Pretreatment with GABA also significantly reduced intrahepatic liver metastasis and primary tumor formation in vivo. Conclusions These findings introduce a potential and novel therapeutic approach for the treatment of cancer patients based on the modulation of the GABAergic system.
Proximal Deep Recurrent Neural Network for Monaural Singing Voice Separation

The recent deep learning methods can offer state-of-the-art performance for Monaural Singing Voice Separation (MSVS). In these deep methods, the recurrent neural network (RNN) is widely employed. This work proposes a novel type of Deep RNN (DRNN), namely Proximal DRNN (P-DRNN) for MSVS, which improves the conventional Stacked RNN (S-RNN) by introducing a novel interlayer structure. The interlayer structure is derived from an optimization problem for Monaural Source Separation (MSS). Accordingly, this enables a new hierarchical processing in the proposed P-DRNN with the explicit state transfers between different layers and the skip connections from the inputs, which are efficient for source separation. Finally, the proposed approach is evaluated on the MIR-IK dataset to verify its effectiveness. The numerical results show that the P-DRNN performs better than the conventional S-RNN and several recent MSVS methods.
Conditionally inducible tau mice – designing a better mouse model of neurodegenerative diseases

Neuronal cell death underlies the majority of age‐related human neurodegenerative disorders that culminate with salient and severe cognitive decline affecting patients’ quality of life, identity and eventually leading to death. The identification of disease‐causing genes in familial forms of neurodegenerative diseases enabled the development of genetic models closely replicating pathologies found in human central nervous system. These models dramatically precipitated our understanding of molecular events leading to neuronal death in many neurodegenerative disorders. Today’s large range of cellular and animal models generate rapidly accumulating biochemical and neuropathological data on changes induced by mutated or dysfunctional proteins implicated in neuronal loss. Most of these models are complementary, although all have intrinsic limitations as well as specific advantages. Development of conditional transgenic mouse models in which a deleterious effect of a transgene can be regulated in a controlled way created new possibilities of addressing the basic mechanisms of neurodegeneration and provided a new angle for the development and testing of new therapeutic approaches.
Crossover versus Mutation: A Comparative Analysis of the Evolutionary Strategy of Genetic Algorithms Applied to Combinatorial Optimization Problems

Since their first formulation, genetic algorithms (GAs) have been one of the most widely used techniques to solve combinatorial optimization problems. The basic structure of the GAs is known by the scientific community, and thanks to their easy application and good performance, GAs are the focus of a lot of research works annually. Although throughout history there have been many studies analyzing various concepts of GAs, in the literature there are few studies that analyze objectively the influence of using blind crossover operators for combinatorial optimization problems. For this reason, in this paper a deep study on the influence of using them is conducted. The study is based on a comparison of nine techniques applied to four well-known combinatorial optimization problems. Six of the techniques are GAs with different configurations, and the remaining three are evolutionary algorithms that focus exclusively on the mutation process. Finally, to perform a reliable comparison of these results, a statistical study of them is made, performing the normal distribution z-test.
Wheat Dough Microstructure: The Relation Between Visual Structure and Mechanical Behavior

The microstructure of food matrixes, and specifically that of wheat-flour dough, determines mechanical behavior. Consequently, the analysis of such microstructure is both necessary and useful for understanding the physico-chemical and mechanical alterations during the production of cereal-based products such as breads. Confocal laser scanning microscopy (CLSM) is an established tool for the investigation of these matrix properties due to its methodical advantages such as easy preparation and handling, and the high depth resolution due to the optical sectioning of probes. This review focuses on the microstructure of wheat-flour dough from a mechanical and visual point of view. It provides an overview of the dependencies between the visibly detectable microstructural elements achieved by CLSM and the physical determined rheological properties. Current findings in this field, especially on numerical microstructure features, are described and discussed, and possibilities for enhancing the analytical methodology are presented.
Comparison of subjective wellbeing in substance users and the parents or partners of substance users

INTRODUCTION AND AIMS There is growing interest in the impact of substance use on both the individual consumer's subjective wellbeing (SWB) and the reduced SWB of those closely connected to him or her. The study aimed to compare SWB among substance users ('consumers') and the parents or partners affected by another's substance use, and to evaluate the effect of counselling on changed SWB to 6 months. DESIGN AND METHODS The study used longitudinal data from a not-for-profit treatment service based in Perth, Australia. Subjective wellbeing was assessed with the Personal Wellbeing Index (PWI) at baseline and 6 months. Data were compared to national norms (mean 75.97) with one sample t tests. Change in PWI scores was assessed with generalised linear mixed models, controlling for age, gender, group (consumers versus parents or partners), psychological distress (Kessler-10) and social connectedness (Lubben). RESULTS Of 220 participants, 136 (62%) were consumers and 84 (38%) were parents or partners. At 6 months 123 (56%) were re-interviewed. At baseline, both consumers (mean 53.7) and parents or partners (mean 66.1) had significantly lower PWI scores than national norms. At 6 months, only the substance users' PWI scores remained significantly lower (mean 67.8). Subjective wellbeing significantly increased with time (β = 5.52; 95% confidence interval 3.15, 7.90), with no significant time by group interaction. DISCUSSION AND CONCLUSIONS Both groups showed significant decrements in SWB compared with the general population but with improvements over the study period. However, the lack of a control group prevents definitive assertions on causality for improved SWB.
Supercapacitor leakage in energy-harvesting sensor nodes: Fact or fiction?

As interest in energy-harvesting sensor nodes continues to grow, the use of supercapacitors as energy stores or buffers is gaining popularity. The reasons for their use are numerous, and include their high power density, simple interfacing requirements, simpler measurement of state-of-charge, and a greater number of charging cycles than secondary batteries. However, supercapacitor energy densities are orders of magnitude lower. Furthermore, they have been reported to exhibit significant leakage, and this has been shown to increase exponentially with terminal voltage (and hence stored energy). This observation has resulted in a number of algorithms, designs and methods being proposed for effective operation of supercapacitor-based energy-harvesting sensor nodes. In this paper, it is argued that traditional `leakage' is not as significant as has commonly been suggested. Instead, what is observed as leakage is in fact predominantly due to internal charge redistribution. As a result, it is suggested that different approaches are required in order to effectively utilize supercapacitors in energy-harvesting sensor nodes.
Open mother–pre-schooler communication: Relations with early secure attachment

The study examined the links between early infant-mother attachment assessed using Ainsworth's Strange Situation at 1 year and mother-pre-schooler communication at 4.5 years in 113 mother-child dyads. Mother-child communication was assessed during a reunion that followed a one-hour separation and was classified into one of three Open communication or one of five Non-open communication patterns. Results showed that boys who were classified as Secure (B) in infancy tended to have open communication with their mothers, while children of both genders who were classified as Insecure/Disorganized (D) in infancy were likely to have non-open communication with their mothers. No associations were found between the Insecure/Ambivalent (C) attachment pattern and later communication. The contributions of this study to the understanding of the expression of the secure base phenomenon in open mother-child communication are discussed.
The Pattern of Leptomeningeal Collaterals on CT Angiography Is a Strong Predictor of Long-Term Functional Outcome in Stroke Patients With Large Vessel Intracranial Occlusion

Background and Purpose— The role of noninvasive methods in the evaluation of collateral circulation has yet to be defined. We hypothesized that a favorable pattern of leptomeningeal collaterals, as identified by CT angiography, correlates with improved outcomes. Methods— Data from a prospective cohort study at 2 university-based hospitals where CT angiography was systematically performed in the acute phase of ischemic stroke were analyzed. Patients with complete occlusion of the intracranial internal carotid artery and/or the middle cerebral artery (M1 or M2 segments) were selected. The leptomeningeal collateral pattern was graded as a 3-category ordinal variable (less, equal, or greater than the unaffected contralateral hemisphere). Univariate and multivariate analyses were performed to define the independent predictors of good outcome at 6 months (modified Rankin Scale score ≤2). Results— One hundred ninety-six patients were selected. The mean age was 69±17 years and the median National Institute of Health Stroke Scale score was 13 (interquartile range, 6 to 17). In the univariate analysis, age, baseline National Institute of Health Stroke Scale score, prestroke modified Rankin Scale score, Alberta Stroke Programme Early CT score, admission blood glucose, history of hypertension, coronary artery disease, congestive heart failure, atrial fibrillation, site of occlusion, and collateral pattern were predictors of outcome. In the multivariate analysis, age (OR, 0.95; 95% CI, 0.93 to 0.98; P=0.001), baseline National Institute of Health Stroke Scale (OR, 0.75; 0.69 to 0.83; P<0.001), prestroke modified Rankin Scale score (OR, 0.41; 0.22 to 0.76; P=0.01), intravenous recombinant tissue plasminogen activator (OR, 4.92; 1.83 to 13.25; P=0.01), diabetes (OR, 0.31; 0.01 to 0.98; P=0.046), and leptomeningeal collaterals (OR, 1.93; 1.06 to 3.34; P=0.03) were identified as independent predictors of good outcome. Conclusion— Consistent with angiographic studies, leptomeningeal collaterals on CT angiography are also a reliable marker of good outcome in ischemic stroke.
Foam nest construction and first report of agonistic behaviour in Pleurodema tucumanum (Anura: Leptodactylidae)

Reproductive strategies are the combination of physiological, morphological, and behavioural traits interacting to increase species reproductive success within a set of environmental conditions. While the reproductive strategies of Leiuperinae are known, few studies have been conducted regarding the reproductive behaviour that underlies them. The aim of this study was to document the structural characteristics of nesting microsites, to describe the process of foam nest construction, and to explore the presence of male agonistic and chorus behaviour in Pleurodema tucumanum. Nests were found close to the edge of a temporary pond and the mean temperature of the foam nests was always close to the mean temperature of the pond water. Our observations corroborate that the foam nest construction phases for P. tucumanum are similar to those described for other Leiuperinae, including dispersion and the beating of the foam, realized by male hind limbs. We also recorded the first scientific observations of male agonistic encounter in Pleurodema tucumanum.
A Model of Quality of Work Life, Life Satisfaction and Service Quality

The study was conducted with the purpose of identifying the impact of Quality of Work Life (QWL) on Life Satisfaction (LS) and Service Quality (SQ) among nurses in the public hospitals. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to examine the internal reliability of a measure and structural equation modelling (SEM) was used to test the goodness of the proposed hypothesised model. The findings of the study supported the first two proposed hypotheses that postulated firstly, that the higher the perceived QWL, the higher the LS and, secondly, the higher the perceived QWL, the higher the perceived nursing SQ. The third hypothesis stated that the higher the LS, the higher the nursing SQ was not supported. The implication of the study suggests that nursing staff with high quality of QWL would deliver high SQ and at the same time achieve high LS.
Adult Attachment Style and Suicidality.

BACKGROUND There is evidence in the literature that adverse early attachment experiences and subsequent attachment insecurities during adulthood would lead to pessimism, low self-esteem, hopelessness and, ultimately, to suicide risk. SUBJECTS AND METHODS This paper aims to review finding on the link between attachment style and suicidality. We searched the literature using the database of the U.S. National Center for Biotechnology Information (NCBI)-MedLine/Pubmed system from January 1992 until December 2016. We started with 1992 because, as far as we know, there are no published studies exploring the relationship between suicide and insecure attachment before that year. We considered reports published on the relationship between attachment style and suicidality. We applied several combinations of the following search terms: attachment, adult attachment style and suicidality, suicide, suicidal ideation, suicidal behavior or suicidal thoughts, and suicide attempts. We selected only English language studies. RESULTS Research suggests that insecure attachment style, mostly anxious, and unresolved traumas are associated with an increased suicide risk. Few studies prospectively examined clinical course, comorbid psychiatric disorders, familial suicidality or other psychosocial factors. CONCLUSIONS Further research is needed to highlight the nature of the link between attachment and suicidality. The presence of suicidal ideation and attempts might be a consequence of an underlying interaction between the emergence of psychiatrics symptoms, and the long-lasting presence of inadequate patterns of attachment. Within this context, Separation Anxiety Disorder, categorized in the DSM-5 as a condition not confined to childhood but as an anxiety disorder that may occur through the entire lifespan, might be the a key for the comprehension of this link. From a neurobiological point of view, the role of oxytocin remains unclear.
The Effects of Types of Social Networks, Perceived Social Support, and Loneliness on the Health of Older People

Objectives: To use an ecological model of ageing (Berkman, Glass, Brissette, & Seeman, 2000) which includes upstream social context factors and downstream social support factors to examine the effects of social networks on health. Method: Postal survey responses from a representative population sample of New Zealanders aged 55 to 70 years (N = 6,662). Results: Correlations and multiple regression analyses provided support for a model in which social context contributes to social network type, which affects perceived social support and loneliness, and consequent mental and physical health. Ethnicity was related to social networks and health but this was largely accounted for by other contextual variables measuring socioeconomic status. Gender and age were also significant variables in the model. Discussion: Social network type is a useful way to assess social integration within this model of cascading effects. More detailed information could be gained through the development of our network assessment instruments for older people.
Increased cell proliferation is associated with genomic instability: elevated micronuclei frequencies in estradiol-treated human ovarian cancer cells.

Estrogen-related cancers are often associated with the hormone's tumor promoting activity. Recently, estradiol has also been demonstrated to induce gene mutations in the physiological concentration range. Mitotic disturbances are found at higher concentrations. In the present study we demonstrate data suggesting an additional mechanism for the induction of genetic damage, i.e. chromosomal breakage. Estrogen receptor-positive (BG-1) and -negative (UCI) human ovarian cancer cell lines were investigated for micronucleus formation after treatment with estradiol. BG-1 cells but not UCI cells showed an increase in micronucleus formation which correlated with the estradiol-induced cell proliferation. The specific estradiol receptor antagonist hydroxytamoxifen suppressed the formation of micronuclei in BG-1 cells. Increased micronucleus frequencies were also seen after normalization of the data to the number of cell divisions. Kinetochore analysis revealed a difference between micronuclei induced by picomolar concentrations of estradiol (kinetochore-negative) and micromolar concentrations (predominantly kinetochore-positive) leading to mitotic disturbances. In accordance with this finding, analysis of the cell cycle revealed decreased cell numbers in G(2)/M phase after treatment with picomolar concentrations, usually not found after mitotic disturbances. We hypothesize that hormone-specific forcing of responsive cells through the cell cycle leads to an override of checkpoints operating under homeostatic control of the cell cycle, resulting in genomic instability.
Minimally Invasive Surgery for Traumatic Fractures in Ankylosing Spinal Diseases

Study Design Retrospective case series. Objective Ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH) are two related diseases that significantly increase the risk of unstable spinal fractures from seemingly trivial trauma. Given the older age and higher surgical risk profile of most of these patients, minimally invasive (MIS) approaches to the treatment of such fractures may reduce operative risk and physiologic stress. Methods Eleven consecutive patients with hyperextension thoracolumbar injuries and a diagnosis of AS or DISH admitted to a single level I trauma center between June 2009 and June 2014 were retrospectively reviewed. All patients were treated with MIS stabilization. In addition, the patients were administered the Oswestry Disability Index and EuroQol-5D surveys to evaluate patient-reported outcomes regarding disability and health-related quality of life, respectively. Results Of the 11 patients, 10 were alive at the time of review. The mean follow-up time was 28 months. The average age was 77 years old with a mean body mass index of 34. All patients had severe systemic disease, American Society of Anesthesiologists grade III, with multiple medical comorbidities. Seven segments on average were included in the operative construct. There were no instrumentation failures or nonunions requiring revision surgery. The average postoperative Oswestry disability index was 21.5% (range: 0 to 34%), corresponding to low to moderate disability, and the average EuroQol-5D utility score was 0.77 (range: 0.60 to 1), a similar average postoperative utility value to those published in the literature on elective surgery for degenerative lumbar conditions. Conclusions MIS stabilization, when used on patients with good preoperative neurologic status, can successfully manage spinal fractures in patients with AS and DISH and preserve a favorable postoperative quality of life with limited disability.