Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulation of Insulin Receptor Signaling by the Protein Tyrosine Phosphatase TCPTP

ABSTRACT The human protein tyrosine phosphatase TCPTP exists as two forms: an endoplasmic reticulum-targeted 48-kDa form (TC48) and a nuclear 45-kDa form (TC45). Although targeted to the nucleus, TC45 can exit in response to specific stimuli to dephosphorylate cytoplasmic substrates. In this study, we investigated the downregulation of insulin receptor (IR) signaling by TCPTP. In response to insulin stimulation, the TC48-D182A and TC45-D182A “substrate-trapping” mutants formed stable complexes with the endogenous tyrosine-phosphorylated IR β-subunit in 293 cells. Moreover, in response to insulin stimulation, the TC45-D182A mutant accumulated in the cytoplasm of cells overexpressing the IR and in part colocalized with the IR β-subunit at the cell periphery. These results indicate that the IR may serve as a cellular substrate for both TC48 and TC45. In immortalized TCPTP−/− murine embryo fibroblasts, insulin-induced IR β-subunit tyrosine phosphorylation and protein kinase PKB/Akt activation were enhanced relative to the values in TCPTP+/+ cells. Importantly, the expression of TC45 or TC48 to physiological levels suppressed the enhanced insulin-induced signaling in TCPTP−/− cells. These results indicate that the differentially localized variants of TCPTP may dephosphorylate the IR and downregulate insulin-induced signaling in vivo.
Competencias docentes en la formación inicial del profesorado de educación física (Teaching competences in physical education teacher initial training)

Entre las competencias docentes, conocer los contenidos de la disciplina a impartir y cómo deben ser impartidos resulta de vital importancia. Esta investigación busca (a) conocer si existen diferencias en la percepción de egresados, alumnado y profesorado universitario sobre la adquisición de las competencias de conocimiento del contenido y de conocimiento pedagógico del contenido consideradas en la formación inicial del profesorado de educación física; y (b) conocer si existen diferencias en la percepción sobre la adquisición de estas competencias en función de la titulación (Maestro de Educación Física en Primaria o Ciencias de la Actividad Física y el Deporte). Se contó con 1982 participantes. Los resultados muestran diferencias de percepción en la adquisición de competencias docentes entre los grupos estudiados. Entre titulaciones aparecen diferencias en la promoción de hábitos saludables y la implementación de propuestas de contenidos motrices; en el conocimiento del contenido estas diferencias aparecen en contenidos de expresión corporal y de condición física y salud.Abstract: Knowledge of a discipline contents and how to teach them are among the most vital teaching competences. The aims of this research are: (a) to know whether there are differences in the perception of graduated, current students, and university teachers about the acquisition of content knowledge and pedagogical content knowledge competences considered in physical education teacher initial training; and (b) to know if there are differences in the perception of the acquisition of teaching competences by Degree (Primary Education with Physical Education specialty or Physical Activity and Sport Sciences). There were 1,982 participants. The results showed differences of perception of the acquisition of teaching competences among the studied groups. Between degrees, differences appear in the promotion of healthy habits and the implementation of motor content proposals; in content knowledge competences these differences appear in body expression and physical fitness and health contents.
Resilience in Dementia: Perspectives of Individuals with Dementia and Their Care Partners

This study examined the protective and vulnerability factors operating in the lives of individuals with dementia and their care partners. Semi-structured interviews were conducted with two participants with dementia and five care partner participants. Screening measures were also completed with the participants with dementia to assess cognition, mental health, quality of life, communication, and relative saliency of factors previously identified in the literature. Factors identified by participants with dementia were: ‘Communication’, ‘Family and Friends’, ‘Perspective and Attitude’, and ‘Quality of Care’. Factors identified by care partner participants were: ‘Communication’, ‘Understanding Dementia’, ‘Relationship’, ‘Quality of Care’, and ‘Care of Self’. Based on these factors, this study also identified the possibility of clinical intervention by speech-language pathologists and other health professionals that may help to support or foster resilient behaviour in this population.
On metal-deficient barium stars and their link with yellow symbiotic stars

This paper addresses the question of why metal-deficient barium stars are not yellow symbiotic stars (YSyS). Samples of (suspected) metal-deficient barium (mdBa) stars and YSyS have been collected from the literature, and their properties reviewed. It appears in particular that the barium nature of the suspected mdBa stars needs to be ascertained by detailed abundance analyses. Abundances are therefore derived for two of them, HD 139409 and HD 148897, which reveal that HD 148897 should not be considered a barium star. HD 139409 is a mild barium star, with overabundances observed only for elements belonging to the first s-process peak (Y and Zr). It is only moderately metal-poor ((Fe/H) = 0.4). The evidence for binarity among metal-deficient barium stars is then reviewed, using three different methods: (i) radial-velocity variations (from CORAVEL observations), (ii) Hipparcos astrometric data, and (iii) a method based on the comparison between the Hipparcos and Tycho-2 proper motions. An orbit is obtained for HIP 55852, whereas evidence for the (so far unknown) binary nature of HIP 34795, HIP 76605, HIP 97874 and HIP 107478 is presented. No conclusion regarding the binary nature of HIP 11595, HIP 25161 could be reached. Two stars with no evidence for binarity whatsoever (HIP 58596 and BD +3 ◦ 2688) are candidates low-metallicity thermally-pulsing asymptotic giant branch stars, as inferred from their large luminosities. The reason why mdBa stars are not YSyS is suggested to lie in their different orbital period distributions: mdBa stars have on average longer orbital periods than YSyS, and hence their companion accretes matter at a lower rate, for a given mass loss rate of the giant star. The definite validation of this explanation should nevertheless await the determination of the orbital periods for the many mdBa stars still lacking periods, in order to make the comparison more significant.
Developing employability and job-related skills at mobile learning environments:a case study at an industrial training centre

This study investigates how mobile technologies play a role in the development of employability and job-related skills for trainees at Saudi Aramco’s Industrial Training Centres (SAITCs) in Saudi Arabia. Adopting a case study approach, qualitative and quantitative data was collected from 133 trainees and 29 instructors participating in an iPad training programme at SAITCs. The data was collected through semi-structured online questionnaires, interviews, onsite observations, and program documents. Findings of this study were linked to existing literature on mobile learning (M-Learning); especially in Vocational and Technical Education and Training (VTET) contexts. It is anticipated that the findings of this study will contribute to the community of researchers and educators in the field of educational research generally, the field of M-Learning, and VTET in particular, in a number of ways. Firstly, this study provides new insights on how mobile devices play a role in the development of employability and job-related skills in industrial training workplaces. Secondly, it offers a better understanding of the key aspects, dynamics, and features of M-Learning environments in the field of VTET. Third, it presents new insights on how mobile devices are linked with specific learning and teaching approaches and practices that have the potential to impact the learning and teaching experience. It is suggested that the findings of this study will have some impact on the perceptions and practices of curriculum developers and the pedagogical considerations of trainees and instructors in terms of learning and teaching with mobile devices. Finally, this research will offer some insights to Saudi Aramco policy makers and administrators that will enable them to improve the full implementation of the iPad program across the training centres.
Salience, Cognitive Effort, and Word Learning : Insights from Pupillometry

Understanding the roles of general cognitive processes in language learning is one of the central goals of research in second language acquisition (SLA). Of these cognitive processes, the role of attention in second language (L2) learning are central to numerous theoretical frameworks (e.g., Ellis, 2006; Gass, 1997; Leow, 2015; Schmidt, 1990; Tomlin & Villa, 1994). As attention plays a critical role in these frameworks, factors that constrain and direct learners’ attention should, therefore, also play critical roles. One such factor is salience (e.g., Ellis, 2006; Leow, Egi, Nuevo, & Tsai, 2003). In a given learning context, allocation of attention— and therefore the amount of attentiondriven learning— should be at least partly determined by the salience of a given form in the input. On this assumption, researchers have employed a variety of methods aimed at promoting attentional processing, most of which involve making linguistic stimuli more salient. Perhaps the most widely employed method of increasing salience involves some kind of input enhancement (for overviews, see Han, Park, & Combs, 2008; Lee & Huang, 2008; Leow & Martin, Chapter 9). Input enhancement is typically conceived of as a way for researchers or educators to direct learners’ attention to specific information in the input. Sharwood Smith (1991, 1993) argued that this input enhancement makes target information more perceptually salient and more likely to be noticed (see also Gass, 1988; Schmidt, 1990). His theory builds on the assumption that noticing is necessary for learning, and that internallyand externallydriven salience govern the learner’s ability to notice particular types of information in the input. To promote learners’ noticing in visual modalities, which is our present focus, researchers and educators can manipulate the visual perceptual salience of textbased linguistic features by manipulating the text through techniques like color coding, highlighting, and boldfacing, henceforth referred to as textual enhancement (TE). 10
On-wafer calibration algorithm for partially leaky multiport vector network analyzers

A new solution for multiport vector network analyzer calibration is presented in this paper. The error model is divided in two separate leaky halves, each of them with crosstalk terms, but without the leakage between the two sides. This error model is particularly useful for on-wafer measurements, when multisignal probes are employed and the crosstalk among probe fingers may dramatically affect the measurement accuracy. We will show that, with a simple choice of calibration standards, the new procedure takes the same time of a classical two-port line-reflect-match or thru-reflect-line calibration. The proposed algorithm is verified with measurements and simulations in both coaxial and on-wafer environments.
A Note on Regime Switching, Monetary Policy, and Multiple Equilibria

When monetary policy is subject to regime switches conditions for determinacy become more complex. Davig and Leeper (2007) and Farmer, Waggoner and Zha (2009a) have studied such conditons. Using some new results from stochastic processes, we characterize the moments of the stationary distribution of inflation under regime switiching to obtain conditions for indeterminacy that can be easily checked and interpreted in terms of expected values of Taylor coefficients. In the last section, we outline methods to compute the moments of stationary distributions in regime switching models of higher dimensions.
1 FINANCE APPLICATIONS OF GAME THEORY

Finance is concerned with how the savings of investors are allocated through financial markets and intermediaries to firms, which use them to fund their activities. Finance can be broadly divided into two fields. The first is asset pricing, which is concerned with the decisions of investors. The second is corporate finance , which is concerned with the decisions of firms. Traditional neoclassical economics did not attach much importance to either kind of finance. It was more concerned with the production, pricing and allocation of inputs and outputs and the operation of the markets for these. Models assumed certainty and in this context financial decisions are relatively straightforward. However, even with this simple methodology, important concepts such as the time value of money and discounting were developed.
A hybrid topological and structural optimization method to design a 3-DOF planar motion compliant mechanism

This paper proposes a novel design methodology to synthesize flexure-based parallel manipulators (FPM) for high precision micro/nano-scale manipulation. Unlike traditional synthesis methods, the proposed method uses a structural optimization algorithm that is independent of human intuition, to synthesize compliant joints with optimal stiffness characteristics. This algorithm is able to evolve the topology and shape of the compliant joints. Based on finite element analysis, the synthesized compliant joints are able to achieve better stiffness characteristics than the traditional compliant joints. This allows the synthesized joints to achieve a large deflection range while maintaining their capabilities to resist external wrenches in the non-actuating directions. A planar motion FPM with a workspace of 4 mm2 × 2° is formed by assembling the optimal compliant joints. The actuating compliance of the joints and FPM are validated by experiments and their deviation between the experimental results and the simulation prediction are within 10% and 18% respectively.
BugWorld: A distributed environment for the development of controlarchitectures in multi-agent worlds

This software allows the simulation of several autonomous agents (simulated robots or simply bugs) equipped with distance sensors. Each bug can deene a unique set of distance sensors located in the center of its circular body. The simulator consists of several diierent processes. Each new agent is a separate process that communicates with the simulator via Internet. In this way a great many of agents can be simulated at the same time on diierent workstations. The process that maintains all the information about the simulated world can run on a separate machine and is not slowed down by agents that might need more and more CPU time as the complexity of their architectures increases.
Supplementary Information on : Malaria pigment crystals as magnetic micro-rotors : key for high-sensitivity diagnosis

Morphology and crystallographic axes. Although there is no apparent difference in sense of orientation between the ensemble of magnetically aligned and randomly distributed crystals (for comparison of the former and latter cases see Fig. S2 and Fig. 1c, respectively), for the magnetically aligned samples we found macroscopic linear dichroism in contrast to the unordered ones. The lack of morphological alignment of the crystals reflecting their magnetic co-alignment is a consequence of the nearly isotropic distribution of the hard axes in the ordered state within the plane perpendicular to the magnetic field and the angle of δ≈60 spanned by the hard axes and the fore-axes of the crystals. The latter introduces another degree of freedom in their alignment, namely arbitrary rotation around their hard axis, which costs no magnetic energy.
The Effects of Photon Bubble Instability in Radiation-dominated Accretion Disks

We examine the effects of photon bubble instability in radiation-dominated accretion disks such as those found around black holes in active galactic nuclei and X-ray binary star systems. Two- and three-dimensional numerical radiation MHD calculations of small patches of disk are used. Modes with wavelengths shorter than the gas pressure scale height grow faster than the orbital frequency in the disk surface layers. The fastest growth rate observed is 5 times the orbital frequency and occurs on nearly vertical magnetic fields. The spectrum of linear modes is in good agreement with a WKB analysis that indicates still faster growth at unresolved scales, with a maximum growth rate proportional to the gravitational acceleration and inversely proportional to the gas sound speed. Disturbances reaching nonlinear amplitudes steepen into trains of shocks similar to a one-dimensional periodic nonlinear analytic solution. Variations in propagation speed result in merging of adjacent fronts, and over time the shock spacing and amplitude increase. Growth is limited by the strength of the magnetic field. The shock train structure is disrupted when the ram pressure of the disturbances exceeds the magnetic pressure. The maximum horizontal density variations are comparable to the ratio of magnetic to gas pressure and in our calculations exceed 100. Under the conditions considered, radiation diffuses through the inhomogeneneous flow 5 times faster than through the initial hydrostatic equilibrium, and the net cooling rate is several times greater than in a similar calculation without magnetic fields that shows the effects of convection. These results indicate that photon bubbles may be important in cooling radiation-dominated accretion disks. The Shaviv type I global instability grows faster than the orbital frequency in calculations of the disk surface layers with lower boundaries of fixed temperature, but is weak or absent in calculations spanning the disk thickness.
An Investigation into the Determinant of Service Quality among Management Students (Empirical Study of Iranian Students)

This study explores the Iranian education to generate a curriculum that should be comprehensive of the rich inheritance of different variables like knowledge, skill and attitude. For that purpose, Service Quality (SERVQUAL) is a standard instrument to evaluation the level of quality provided. The present study is an attempt to measure the level of Service Quality provided by Zenithal in the field of technical education among management students. The results of the questionnaire survey are analyzed in relation to the five Service Quality (SERVQUAL) dimensions (tangibles; reliability; responsiveness; assurance; empathy) and revealed that various aspects of quality differ significantly based on some demographic variables.
A Unified Framework for Large-and Small-Displacement Optical Flow Estimation

We propose a unified framework for both largeand small-displacement optical flow estimation based on the observation that fine motion structures, especially those with significant and abrupt displacement transition, cannot always be correctly reconstructed in the commonly employed multi-scale variational framework. A novel extended coarse-to-fine (EC2F) refinement framework is introduced in this paper to address this issue, which reduces the reliance of the flow estimates on their initial values propagated from the coarser level and enables recovering many motion details in each scale. The contribution of this paper also includes adaption of the objective function and development of a new optimization procedure. The effectiveness of our method is borne out by experiments for both largeand small-displacement optical flow estimation.
The Gender Factor Effect on Saudi Learners’ Perceptions of Using Social Media on Their Social Interaction

This study compares males and females perception of the effect of social media on their social interaction to understand the difference between both genders. The study follows a mixed-method methodology using a questionnaire with closed-ended items and open-ended questions. Responses to the questionnaire are collected form 207 male and female students from a public university in Saudi Arabia. In general, the results of the questionnaire are insignificant which indicate that there are no differences between both genders. However, the results of the open-ended questions show that females have a negative view of the effect of social media on human relations while males have a positive point of view. However, both genders have a positive point of view regarding balancing between friends and family in real life and virtual world through time management.
Doing Reflexivity: An Introduction

ly, Beyond Trans takes us there; and, ultimately, as Davis points out, the benefits of reconfiguring how we approach sex classification will reach all members of our society. Perhaps you’re reading this and wondering where to start. If that’s the case, worry not—you can flip to the appendix of Beyond Trans and check out the handy step-by-step guide Davis uses in his own activist work around these very issues for more information.
Eliciting patients' concerns: a randomised controlled trial of different approaches by the doctor.

BACKGROUND Although a 'patient-centred' approach to general practice consultation is widely advocated, there is mixed evidence of its benefits. AIM To measure the costs and benefits of using a prompt to elicit patients' concerns when they consult for minor illness. DESIGN OF STUDY An open randomised controlled trial. SETTING Four training semi-rural general practices in the south- east of the United Kingdom. METHOD Patients identified during the first part of the consultation as having a self-limiting illness were randomised to a second part of the consultation that was conducted 'as usual' or involved a written prompt to elicit the patient's concerns. After each consultation the doctor noted the diagnosis and the consultation length and the patient self-completed a questionnaire containing measures of satisfaction, enablement and anxiety. RESULTS One hundred and ten patients were studied. Patients in the elicitation group reported a small but significant increase in the 'professional care' score of the consultation satisfaction questionnaire (88.2 versus 80.9, mean difference = 7.3, 95% confidence interval = 2.0 to 12.6) but no other benefits were detected. Consultations in the elicitation group, however, were longer by about a minute. CONCLUSION Given the pressures on consultation time in general practice there must be questions about the practical value of eliciting patients' concerns if the benefit of doing so is small and the cost large.
A hybrid back-transliteration system for Japanese

Transliterating words and names from one language to another is a frequent and highly productive phenomenon. Transliteration is information losing since important distinctions are not preserved in the process. Hence, automatically converting transliterated words back into their original form is a real challenge. In addition, due to its wide applicability in MT and CLIR, it is an interesting problem from a practical point of view. In this paper, we propose a new method, combining the transliterated string segmentation module with phoneme-based and grapheme-based transliteration modules in order to enhance the back-transliterations of Japanese words. Our experiments show significant improvements achieved by the hybrid approach.