Miracle-dz/UniFAR-FTUs huggingface dataset:
College Students and Stress Management: Utilizing Biofeedback and Relaxation Skills Training

COLLEGE STUDENTS AND STRESS MANAGEMENT: UTILIZING BIOFEEDBACK AND RELAXATION SKILLS TRAINING Shannon Jones Anstead Department of Counseling Psychology and Special Education Educational Specialist in School Psychology This study was undertaken to evaluate the effectiveness of biofeedback and relaxation skills training to help alleviate college students’ stress symptoms. Data was collected from 659 full-time college students who attended a total of 1,170 biofeedback sessions over the course of two years. Results of the study indicated that the top three stress-related symptoms students experienced were (a) feeling overwhelmed, (b) feeling anxious, and (c) difficulty concentrating. Furthermore, the top three stressors rated by students were (a) too much to do, (b) homework, and (c) classes and school. In addition, the top three coping strategies utilized by students to manage their stress were (a) prayer, (b) exercise, and (c) talking to friends. Moreover, results also showed significant differences on all three pre and post measures regarding skin temperature readings, EMG readings, and students’ subjective self-report ratings of degree of stress. Specifically, students’ skin temperature increased and their muscle tension decreased, indicating less physiological tension at the end of the session. Furthermore, comparisons of students’ selfreport ratings of their degree of stress before and after the session indicated that they felt less stressed and more relaxed at the conclusion of the session. These findings lend support to the utility of colleges providing biofeedback and relaxation skills training as an intervention for college students to utilize. In this way students become empowered to self-regulate their stress symptoms and optimize their health. Indeed, students can utilize and benefit from these skills both during and beyond their college years.
Inference and communication in the game of Password

Communication between a speaker and hearer will be most efficient when both parties make accurate inferences about the other. We study inference and communication in a television game called Password, where speakers must convey secret words to hearers by providing one-word clues. Our working hypothesis is that human communication is relatively efficient, and we use game show data to examine three predictions. First, we predict that speakers and hearers are both considerate, and that both take the other's perspective into account. Second, we predict that speakers and hearers are calibrated, and that both make accurate assumptions about the strategy used by the other. Finally, we predict that speakers and hearers are collaborative, and that they tend to share the cognitive burden of communication equally. We find evidence in support of all three predictions, and demonstrate in addition that efficient communication tends to break down when speakers and hearers are placed under time pressure.
POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in Head and Neck cancer

HOX genes are master regulators of organ morphogenesis and cell differentiation during embryonic development, and continue to be expressed throughout post-natal life. To test the hypothesis that HOX genes are dysregulated in head and neck squamous cell carcinoma (HNSCC) we defined their expression profile, and investigated the function, transcriptional regulation and clinical relevance of a subset of highly expressed HOXD genes. Two HOXD genes, D10 and D11, showed strikingly high levels in HNSCC cell lines, patient tumor samples and publicly available datasets. Knockdown of HOXD10 in HNSCC cells caused decreased proliferation and invasion, whereas knockdown of HOXD11 reduced only invasion. POU2F1 consensus sequences were identified in the 5′ DNA of HOXD10 and D11. Knockdown of POU2F1 significantly reduced expression of HOXD10 and D11 and inhibited HNSCC proliferation. Luciferase reporter constructs of the HOXD10 and D11 promoters confirmed that POU2F1 consensus binding sites are required for optimal promoter activity. Utilizing patient tumor samples a significant association was found between immunohistochemical staining of HOXD10 and both the overall and the disease-specific survival, adding further support that HOXD10 is dysregulated in head and neck cancer. Additional studies are now warranted to fully evaluate HOXD10 as a prognostic tool in head and neck cancers.
Effect of Grip Width on Electromyographic Activity During the Upright Row

Abstract McAllister, MJ, Schilling, BK, Hammond, KG, Weiss, LW, and Farney, TM. Effect of grip width on electromyographic activity during the upright row. J Strength Cond Res 27(1): 181–187, 2013—The upright row (URR) is commonly used to develop the deltoid and upper back musculature. However, little information exists concerning muscle recruitment during variations of this exercise. Sixteen weight-trained men completed 2 repetitions each in the URR with 3 grip conditions: 50, 100, and 200% of the biacromial breadth (BAB). The load was the same for all grip conditions and was equal to 85% of the 1RM determined at 100% BAB. Repeated measures analyses of variance were used to compare the maximal activity of the anterior deltoid (AD), lateral deltoid (LD), posterior deltoid (PD), upper trapezius (UT), middle trapezius (MT), and biceps brachii (BB) during the 3 grip widths for eccentric and concentric actions. Significant differences (p < 0.05) were noted in concentric muscle activity for LD (p < 0.001) and PD (p < 0.001), and in eccentric muscle activity for AD (p = 0.023), LD (p < 0.001), UT (p < 0.001), MT (p < 0.001), and BB (p = 0.003). Bonferroni post hoc analysis revealed significant pairwise differences in the concentric actions from the LD (50% vs. 200% BAB and 100% vs. 200% BAB) and PD (50% vs. 200% BAB and 100% vs. 200% BAB), and eccentric actions of the LD (all comparisons), UT (all comparisons), MT (50% vs. 200% BAB and 100% vs. 200% BAB), and BB (50% vs. 200% BAB), with large-to-very-large effect sizes (ESs). Moderate-to-large ESs were noted for several nonsignificant comparisons. The main findings of this investigation are increased deltoid and trapezius activity with increasing grip width, and correspondingly less BB activity. Therefore, those who seek to maximize involvement of the deltoid and trapezius muscles during the URR should use a wide grip.
Cellular and molecular predictors of chronic renal dysfunction after initial ischemia/reperfusion injury of a single kidney.

BACKGROUND Initial ischemia/reperfusion injury occurring secondary to organ retrieval, storage, and transplantation has been associated with late renal allograft deterioration and failure. In addition, there is an apparent synergy, reported in several clinical series, between the initial injuries of ischemia/reperfusion and acute rejection; the long-term results of graft survival are significantly deceased after both events in combination as compared with either alone or if no such episodes occur. METHODS In the present study, we examined patterns of proteinuria, cellular infiltration, cytokine expression, and glomerulosclerosis over time in Lewis and Fischer 344 rats after 45 min of warm ischemia of a single kidney and with or without contralateral nephrectomy. Both early (4 hr to 7 days) and late (2-52 weeks) events were studied serially in the affected kidneys morphologically, by immunohistology and by reverse transcriptase polymerase chain reaction. RESULTS Intercellular adhesion molecule 1, endothelin, and major histocompatibility complex class II expression were up-regulated within 2 to 5 days after injury; T cells and macrophages increased transiently. Proteinuria developed after approximately 8 weeks only in animals bearing a single injured kidney, and not in those with a retained native organ. Progressive morphological changes occurred after 16 weeks, including glomerulosclerosis, arterial obliteration, and interstitial fibrosis. After a period of relative quiescence, expression of intercellular adhesion molecule 1 again increased in relation to progressive macrophage infiltration and their associated products, particularly, interleukin 1, tumor necrosis factor-alpha, transforming growth factor-beta, and inducible nitric oxide synthase. Monocyte chemotactic protein 1 was intensely up-regulated by 24 weeks, coincident with a dramatic rise in this infiltrating population. These changes remained virtually at baseline in animals with a retained native kidney. CONCLUSIONS These data imply that chronic injury after significant initial ischemia and reperfusion occurs when there is already a 50% renal mass reduction, but not when two kidneys remain in place. Permanent nephron loss resulting from such an insult could account for this phenomenon. Early ischemia and reperfusion, if severe enough in a single kidney, may be an important antigen-independent risk factor for later renal deterioration and failure. In the context of a renal allograft, it may contribute to chronic rejection.
Selective molecular transport through the protein shell of a bacterial microcompartment organelle

Significance Here, we describe a type of selective channel formed by a nonmembrane protein that is used to control metabolite movement between cellular compartments. In this case, the channel controls the movement of metabolites between the bacterial cytoplasm and the lumen of a bacterial microcompartment, a primitive organelle that is bounded by a protein shell and lacks any lipid bilayer. These studies are the first to our knowledge to prove selective molecular transport through a protein-based barrier. These findings broaden our understanding of how cells control the movement of molecules between cellular compartments, which is fundamental to biological systems. It also solves a key question about the function of bacterial microcompartments, which themselves impact many diverse and important biological processes. Bacterial microcompartments are widespread prokaryotic organelles that have important and diverse roles ranging from carbon fixation to enteric pathogenesis. Current models for microcompartment function propose that their outer protein shell is selectively permeable to small molecules, but whether a protein shell can mediate selective permeability and how this occurs are unresolved questions. Here, biochemical and physiological studies of structure-guided mutants are used to show that the hexameric PduA shell protein of the 1,2-propanediol utilization (Pdu) microcompartment forms a selectively permeable pore tailored for the influx of 1,2-propanediol (the substrate of the Pdu microcompartment) while restricting the efflux of propionaldehyde, a toxic intermediate of 1,2-propanediol catabolism. Crystal structures of various PduA mutants provide a foundation for interpreting the observed biochemical and phenotypic data in terms of molecular diffusion across the shell. Overall, these studies provide a basis for understanding a class of selectively permeable channels formed by nonmembrane proteins.
Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era.

CONTEXT Children with meningitis are routinely admitted to the hospital and administered broad-spectrum antibiotics pending culture results because distinguishing bacterial meningitis from aseptic meningitis is often difficult. OBJECTIVE To develop and validate a simple multivariable model to distinguish bacterial meningitis from aseptic meningitis in children using objective parameters available at the time of patient presentation. DESIGN Retrospective cohort study of all children with meningitis admitted to 1 urban children's hospital from July 1992 through June 2000, randomly divided into derivation (66%) and validation sets (34%). PATIENTS Six hundred ninety-six previously healthy children aged 29 days to 19 years, of whom 125 (18%) had bacterial meningitis and 571 (82%) had aseptic meningitis. INTERVENTION Multivariable logistic regression and recursive partitioning analyses identified the following predictors of bacterial meningitis from the derivation set: Gram stain of cerebrospinal fluid (CSF) showing bacteria, CSF protein > or =80 mg/dL, peripheral absolute neutrophil count > or =10 000 cells/mm3, seizure before or at time of presentation, and CSF absolute neutrophil count > or =1000 cells/mm3. A Bacterial Meningitis Score (BMS) was developed on the derivation set by attributing 2 points for a positive Gram stain and 1 point for each of the other variables. MAIN OUTCOME MEASURE The accuracy of the BMS when applied to the validation set. RESULTS A BMS of 0 accurately identified patients with aseptic meningitis without misclassifying any child with bacterial meningitis in the validation set. The negative predictive value of a score of 0 for bacterial meningitis was 100% (95% confidence interval: 97%-100%). A BMS > or =2 predicted bacterial meningitis with a sensitivity of 87% (95% confidence interval: 72%-96%). CONCLUSIONS The BMS accurately identifies children at low (BMS = 0) or high (BMS > or =2) risk of bacterial meningitis. Outpatient management may be considered for children in the low-risk group.
Analysis of orbital malignancies presenting in a tertiary care hospital in Pakistan

Objective: To determine the frequencies of various orbital malignancies amongst orbital lesions in patients presenting in a tertiary care hospital in Pakistan. Methods: A retrospective analysis of 666 orbital cases with an established histopathological diagnosis of malignant tumors treated in Mayo Hospital Lahore from 1996 to 2015 (20 years). Results: About 66% of the malignant tumors were primary, 25% secondary, 8% haematopoietic and 1% metastatic. Almost 50% of the cases were children. Retinoblastoma is the commonest tumor (43% overall and 87% among children). Squamous cell carcinoma is the second commonest (15.6% overall and 31% among adults). These are then followed by Adenoid cystic carcinoma of Lacrimal Gland (9%), Lymphoma/Leukaemia (8%) and Rhabdomyosarcoma (6.3%). Conclusion: Frequencies of various orbital malignancies show geographical variation in both paediatric and adult population.
Role of Sphingosine‐1‐Phosphate in Transplant Vasculopathy Evoked by Anti‐HLA Antibody

Transplant vasculopathy (TV) represents the main cause of late graft failure and limits the long‐term success of organ transplantation. Cellular and humoral immune responses contribute to the pathogenesis of the concentric and diffuse intimal hyperplasia of arteries of the grafted organ. We recently reported that the mitogenic signaling, evoked in human vascular smooth muscle cells (hmSMC) by the anti‐HLA class I monoclonal antibody W6/32, implicates neutral sphingomyelinase‐2, suggesting a role for sphingolipids in intimal hyperplasia of TV. Here, we investigated whether the mitogenic sphingolipid, sphingosine‐1‐phosphate (S1P), is involved in intimal hyperplasia elicited by W6/32. Studies were done on cultured hmSMC and on an in vivo model of TV, consisting of human mesenteric arteries grafted into SCID/beige mice, injected weekly with W6/32. hmSMC migration and DNA synthesis elicited by W6/32 were inhibited by the sphingosine kinase‐1 (SK1) inhibitor dimethylsphingosine, the anti‐S1P antibody Sphingomab and the S1PR1/R3 inhibitor VPC23019. W6/32 stimulated SK1 activity, while siRNA silencing SK1, S1PR1 and S1PR3 inhibited hmSMC migration. In vivo, Sphingomab significantly reduced the intimal thickening induced by W6/32. These data emphasize the role of S1P in intimal hyperplasia elicited by the humoral immune response, and open perspectives for preventing TV with S1P inhibitors.
Single‐mode optically activated phase modulator on GaAs/GaAlAs compound semiconductor rib waveguides

We report on an optically activated phase modulator (OAM) and modulator array on GaAs‐GaAlAs compound semiconductor rib waveguides. A rib waveguide device with an optical activation window of 5 μm in diameter was fabricated. Optical activation was produced by using a HeNe 632.8 nm wavelength as the free‐carrier generator and a 1.3 μm laser as the signal carrier. A 33% modulation depth was observed and 10−2 index modulation was experimentally confirmed on an OAM working in the phase modulation regime. OAMs working in both phase‐ and cutoff‐modulation regimes were further determined by considering the variation of the waveguide confinement factor. An 8.2 dB modulation depth was observed on an OAM working at the cutoff regime. Furthermore, the activation source for the free‐carrier generation is in the mW power region, which significantly reduces the size and cost of all optical switching devices.
Ju l 2 00 2 ITEP – TH – 34 / 02 Wilson loops in N = 4 SYM theory : rotation in S 5

We study Wilson loops in N = 4 SYM theory which are non-constant in the scalar (S5) directions and open string solutions associated with them in the context of AdS/CFT correspondence. An interplay between Minkowskian and Euclidean pictures turns out to be non-trivial for time-dependent Wilson loops. We find that in the S5-rotating case there appears to be no direct open-string duals for the Minkowskian Wilson loops, and their expectation values should be obtained by analytic continuation from the Euclidean-space results. In the Euclidean case, we determine the dependence of the “quark – anti-quark” potential on the rotation parameter ν, both at weak coupling (i.e. in the 1-loop perturbative SYM theory) and at strong coupling (i.e. in the classical string theory in AdS5 × S5). 1 Also at Lebedev Physics Institute, Moscow, Russia. e-mail: tseytlin.1@osu.edu, tseytlin@ic.ac. uk. Also at ITEP, B. Cheremushkinskaja, 25, 117259 Moscow, Russia. e-mail: Konstantin.Zarembo@teorfys.uu. se
Impaired “Affective Theory of Mind” Is Associated with Right Ventromedial Prefrontal Damage

Objective:To examine the hypothesis that patients with ventromedial (VM) frontal lesions are impaired in the affective rather than cognitive facets of theory of mind (ToM). Background:Prefrontal brain damage may result in impaired social behavior, especially when the damage involves the orbitofrontal/VM prefrontal cortex (PFC). It has been previously suggested that deficits in ToM may account for such aberrant behavior. However, inconsistent results have been reported, and different regions within the frontal cortex have been associated with ToM impairment. Method:The performance of 26 patients with localized lesions in the PFC was compared with responses of 13 patients with posterior lesions and 13 normal control subjects. Three ToM tasks differing in the level of emotional processing involved were used: second-order false belief task, understanding ironic utterances, and identifying social faux pas. Results and Conclusions:The results indicated that patients with VM (but not dorsolateral) prefrontal lesions were significantly impaired in irony and faux pas but not in second-order false belief as compared with patients with posterior lesions and normal control subjects. Lesions in the right VM area were associated with the most severe ToM deficit. These results are discussed in terms of the cognitive and affective facets of “mind-reading” processes mediated by the VM cortex.
Insulin-Regulated Srebp-1c and Pck1 mRNA Expression in Primary Hepatocytes from Zucker Fatty but Not Lean Rats Is Affected by Feeding Conditions

Insulin regulates the transcription of genes for hepatic glucose and lipid metabolism. We hypothesized that this action may be impaired in hepatocytes from insulin resistant animals. Primary hepatocytes from insulin sensitive Zucker lean (ZL) and insulin resistant Zucker fatty (ZF) rats in ad libitum or after an overnight fasting were isolated, cultured and treated with insulin and other compounds for analysis of gene expression using real-time PCR. The mRNA levels of one insulin-induced (Srebp-1c) and one insulin-suppressed (Pck1) genes in response to insulin, glucagon, and compactin treatments in hepatocytes from ad libitum ZL and ZF rats were analyzed. Additionally, the effects of insulin and T1317 on their levels in hepatocytes from ad libitum or fasted ZL or ZF rats were compared. The mRNA levels of Srebp-1c, Fas, and Scd1, but not that of Insr, Gck and Pck1, were higher in freshly isolated hepatocytes from ad libitum ZF than that from ZL rats. These patterns of Srebp-1c and Pck1 mRNA levels remained in primary hepatocyte cultured in vitro. Insulin's ability to regulate Srebp-1c and Pck1 expression was diminished in hepatocytes from ad libitum ZF, but not ZL rats. Glucagon or compactin suppressed Srebp-1c mRNA expression in lean, but not fatty hepatocytes. However, glucagon induced Pck1 mRNA expression similarly in hepatocytes from ad libitum ZL and ZF rats. Insulin caused the same dose-dependent increase of Akt phosphorylation in hepatocytes from ad libitum ZL and ZF rats. It synergized with T1317 to induce Srebp-1c, and suppressed Pck1 mRNA levels in hepatocytes from fasted, but not that from ad libitum ZF rats. We demonstrated that insulin was unable to regulate its downstream genes' mRNA expression in hepatocytes from ad libitum ZF rats. This impairment can be partially restored in hepatocytes from ZF rats after an overnight fasting, a phenomenon that deserves further investigation.
Network-based language teaching and the development of intercultural communicative competence

Zugriff auf den Volltext ist aus datenschutzrechtlichen Grunden gesperrt, neue Version unter DuEPublico-ID 33547 This thesis reports the findings of three qualitative studies which were carried out in EFL classes at the University of Duisburg-Essen, Germany between 2001 and 2003. All three groups used various combinations of communication technologies such as e-mail, web-based message boards and videoconferencing in order to engage in on-line exchanges with different partner classes in Ireland and the USA. The research was aimed at establishing, firstly, how such virtual intercultural contact can contribute to the development of intercultural communicative competence, and secondly, what skills and knowledge both students and teachers need in order to engage successfully in this complex on-line learning activity. The research revealed that the success of such exchanges often depends on their appropriate integration into the language classroom and that it is necessary to reassess the role of the teacher in telecollaborative exchanges.