Miracle-dz/UniFAR-FTUs huggingface dataset:
Light induced intraspecific variability in response to thermal stress in the hard coral Stylophora pistillata

Recent research suggests that prior exposure of several months to elevated irradiance induces enhanced thermal tolerance in scleractinian corals. While this tolerance has been reported at the species level, individual coral colonies may react differently due to individual variability in thermal tolerance. As thermal anomalies are predicted to become common in the upcoming future, intraspecific variation may be key to the survival of coral populations. In order to study light-history based thermal stress responses on individual colonies, we developed a preliminary microcosm experiment where three randomly chosen, aquacultured colonies of the model coral Stylophora pistillata were exposed to two irradiance treatments (200 and 400 μmol photons m−2 s−1) for 31 days, followed by artificially induced heat stress (∼33.4 °C). We found different responses to occur at both the intraspecific and the intracolonial levels, as indicated by either equal, less severe, delayed, and/or even non-necrotic responses of corals previously exposed to the irradiance of 400 compared to 200 μmol photons m−2 s−1. In addition, all individual colonies revealed light-enhanced calcification. Finally, elevated irradiance resulted in a lower chlorophyll a concentration in one colony compared to the control treatment, and the same colony displayed more rapid bleaching compared to the other ones. Taken together, this study highlights the potential importance of intra-individual variability in physiological responses of scleractinian corals and provides recommendations for improving methodological designs for future studies.
Structural and Reactivity Alterations of the Renal Vasculature of Spontaneously Hypertensive Rats Prior to and During Established Hypertension

The renal vasculatures of Wlstar Kyoto spontaneously hypertensive rats (SHR), prior to (4-5 week) and during established hypertension (21 week) and those of age-matched Wistar Kyoto normotensive rats (WKY) were morphometrically and pharmacologically studied. Under dilated conditions, the vascular resistances (RVR) of the isolated kidneys of young and adult SHR were similar to WKY. Morphometric measurements of renal vasculature indicated that the cross-sectional area of the intima and ad ventitia and its subcomponents were similar in adult SHR and WKY. With the exception of the preglomerular arterioles, all the renal arteries of adult SHR exhibited elevated cross-sectional quantities of total media, medial smooth muscle cells (SMCs), and extracellular space. Analysis of the SMCs indicated the presence of increased numbers of SMC layers and/or an increase in the SMC volume-to-surface area ratio in arteries sampled from adult SHR. Vascular contraction produced by infusing norepinephrine, BaCl2, angiotensin II, or by stimulating the renal nerves elevated the RVR to a greater degree hi adult SHR than in WKY. The sensitivity of the renal vasculature to the various contractile agents was similar in adult SHR and WKY. When compared with WKY, prehypertensive SHR also exhibited increased cross-sectional quantities of arterial media and elevated amplitudes of RVR change in response to norepinephrine and renal nerve stimulation. However, the vascular contractile sensitivity to norepinephrine was reduced. Our results indicate that renovascular wall thickening and the hypercontractile reactivity associated with such a change precedes hypertension in SHR. In prehypertensive SHR, elevations in RVR might be counterbalanced by a decreased norepinephrine sensitivity. An increase in the norepinephrine contractile sensitivity and further vascular thickening with age could elevate the RVR and establish hypertension.
Diversity and Productivity in a Long-Term Grassland Experiment

Plant diversity and niche complementarity had progressively stronger effects on ecosystem functioning during a 7-year experiment, with 16-species plots attaining 2.7 times greater biomass than monocultures. Diversity effects were neither transients nor explained solely by a few productive or unviable species. Rather, many higher-diversity plots outperformed the best monoculture. These results help resolve debate over biodiversity and ecosystem functioning, show effects at higher than expected diversity levels, and demonstrate, for these ecosystems, that even the best-chosen monocultures cannot achieve greater productivity or carbon stores than higher-diversity sites.
The Albian to Turonian carbon isotope record from the Shilaif Basin (United Arab Emirates) and its regional and intercontinental correlation

The sedimentary record of the Arabian Shelf offers a unique opportunity to study the Cretaceous (Albian–Turonian) greenhouse climate from a palaeoequatorial perspective. In particular, hemipelagic to pelagic carbonate successions from the extensive Shilaif intra‐shelf basin have the potential to produce an excellent record of carbon cycle perturbations during this interval. This study presents a 269 m thick chemostratigraphic (carbonate δ13C and δ18O) record from the Middle Albian to Early Turonian of central Abu Dhabi (United Arab Emirates), representing over 14 Myr of uninterrupted carbonate sedimentation. The Mauddud to Shilaif formations represent outer ramp to basinal intra‐shelf carbonates with variations from laminated organic‐rich to clean bioturbated intervals. Isotopic evidence of the latest Albian Anoxic Event (Oceanic Anoxic Event 1d), Middle Cenomanian Event I and the Cenomanian–Turonian Anoxic Event (Oceanic Anoxic Event 2) are confirmed and biostratigraphically calibrated by means of calcareous nannofossils. The carbon isotope record allows correlation with other regional records and well‐calibrated records across the Tethyan Ocean and represents a significant improvement of the chronostratigraphic framework of the United Arab Emirates (Shilaif) and Oman (Natih) intra‐shelf basins. The study further confirms that low carbon isotope values corresponding to the two source rock intervals in the Shilaif Formation clearly precede the isotopic expressions of Oceanic Anoxic Event 1d and Oceanic Anoxic Event 2.
Mental health help-seeking attitudes, utilization, and intentions among older Chinese immigrants in Canada

Objectives: This study had three objectives. First, to determine the extent to which demographic factors, perceived social support, and Chinese cultural beliefs predict attitudes toward mental health help seeking; second, to assess mental health utilization; and third, to assess intentions to utilize mental health services among older Chinese immigrants in Canada aged 55 and above. Method: A total of 149 older Chinese adults (M = 73.92 years, SD = 9.99, range = 55–95 years) completed a semi-structured interview protocol in Cantonese or Mandarin. Demographic and health information were collected, and questionnaires assessing perceived social support, mental health help-seeking attitudes, and belief in Chinese culture and values were administered. Results: Demographic and health information, perceived social support, Chinese cultural beliefs and values accounted for 21.8% of the variance in help-seeking attitudes. Descriptive data related to mental health utilization and intentions are provided. Conclusion: Older Chinese participants exhibited less positive attitudes that were significantly associated with Chinese cultural beliefs and values. Implications for practice with older Chinese adults are also discussed.
Level of Fatty Acid Binding Protein 5 (FABP5) Is Increased in Sputum of Allergic Asthmatics and Links to Airway Remodeling and Inflammation

Background The inflammatory processes in the upper and lower airways in allergic rhinitis and asthma are similar. Induced sputum and nasal lavage fluid provide a non-invasive way to examine proteins involved in airway inflammation in these conditions. Objectives We conducted proteomic analyses of sputum and nasal lavage fluid samples to reveal differences in protein abundances and compositions between the asthma and rhinitis patients and to investigate potential underlying mechanisms. Methods Induced sputum and nasal lavage fluid samples were collected from 172 subjects with 1) allergic rhinitis, 2) asthma combined with allergic rhinitis, 3) nonallergic rhinitis and 4) healthy controls. Proteome changes in 21 sputum samples were analysed with two-dimensional difference gel electrophoresis (2D-DIGE), and the found differentially regulated proteins identified with mass spectrometry. Immunological validation of identified proteins in the sputum and nasal lavage fluid samples was performed with Western blot and ELISA. Results Altogether 31 different proteins were identified in the sputum proteome analysis, most of these were found also in the nasal lavage fluid. Fatty acid binding protein 5 (FABP5) was up-regulated in the sputum of asthmatics. Immunological validation in the whole study population confirmed the higher abundance levels of FABP5 in asthmatic subjects in both the sputum and nasal lavage fluid samples. In addition, the vascular endothelial growth factor (VEGF) level was increased in the nasal lavage fluid of asthmatics and there were positive correlations between FABP5 and VEGF levels (r=0.660, p<0.001) and concentrations of FABP5 and cysteinyl leukotriene (CysLT) (r=0.535, p<0.001) in the nasal lavage fluid. Conclusions FABP5 may contribute to the airway remodeling and inflammation in asthma by fine-tuning the levels of CysLTs, which induce VEGF production.
A successful academic‐community partnership to improve the public's health

As academic health center seek to address the changes in the health care system and in medical education, several approaches have been tried, some successfully, others not. The authors describe a successful approach that involves a close partnership between the health professions schools at two academic institutions, and agencies from the surrounding community. Specifically, the Center for Healthy Communities, begun in 1991 and formally institutionalized in 1994 in Dayton, Ohio, is a partnership among the schools of medicine, nursing, and professional psychology at Wright State University (WSU); the department of social work at WSU; the Allied Health Division of Sinclair Community College; more than 200 individuals (from grassroots neighborhood people to civic leaders); and 50 health and human services organizations in the Dayton area. The Center is recognized as a force for change in health professions education and health care delivery both in the community and in the academic settings. The authors explain how the Center was formed, list its goals (such as establishing strong partnerships among community educators and providers and educating students in the delivery of primary health care in the community), explain three principles that have been followed and that were crucial to the success of the Center (for example, individuals in the community must become empowered to capitalize on their strengths), and discuss the major difficulties that the community and the academic institutions encountered and strategies for meeting them (such as the importance of building trust and the importance of learning the needs identified by the community partners, not just those identified by the academic partners). The authors maintain that a successful community-academic partnership must be built on the foundation of community health development, a concept analogous to economic development, and that such a partnership can be a powerful tool for making a difference in the community's health.
Penetration of HIV-1 Tat47–57 into PC/PE Bilayers Assessed by MD Simulation and X-ray Scattering

The interactions of the basic, cell-penetrating region (Y47GRKKRRQRRR57) of the HIV-1 Tat protein with dioleoylphosphatidylcholine (DOPC) bilayers were previously assessed by comparing experimental X-ray diffuse scattering with atomistic molecular dynamics simulations. Here, we extend this investigation by evaluating the influence of phosphatidylethanolamine (PE) lipids. Using experimental bilayer form factors derivedfrom X-ray diffuse scattering data as a guide, our simulations indicate that Tat peptides localize close to the carbonyl-glycerol group in the headgroup region of bilayers composed of either DOPC or DOPC:DOPE (1:1) lipid. Our results also suggest that Tat peptides may more frequently insert into the hydrophobic core of bilayers composed of PC:PE (1:1) lipids than into bilayers composed entirely of PC lipids. PE lipids may facilitate peptide translocation across a lipid bilayer by stabilizing intermediate states in which hydrated peptides span the bilayer.
Insecticidal Properties and Chemical Composition of Conyza Aegyptiaca (L.) Oil: Studies on Two Dipterous Insect Pests

The herb, Conyza aegyptiaca L. , was subjected to hydrodistillation process to extract the essential oil from the whole dry plant material. Larvae and adult stages of the mosquito, Anopheles pharoensis, and the housefly, Musca domes- tica, were used as test model organisms representing two dipterous insect pests of medical importance. Under standard bioassay test methods, the LC50 of the oil accounted to 37.8 ppm and 0.087 mg/cm 2 against larvae and adults of An. pharoensis, respectively. These toxicity parameters were found to be 71.8 ppm as LC50 and 0.125 µg/insect as LD50 against larvae and adults of M. domestica, respectively. Using GC/MS analysis, we identified 19 compounds constituting ca. 97% of phytochemicals present in the oil, such as monoterpenes, sesquiterpenes and esters. Limonene constituted about 50% of the plant oil (48.79%), followed by (E) - β-Ocimene (8.66%), Germacrene D (7.54%) and β-pinene (6.91%). The occurrence of the other constituents ranged between 0.27% and 5.29%. It was concluded that the potency of C. aegyptiaca oil refers mainly to the presence of limonene. The findings of this study may encourage more research aiming at investi- gation of eco-friendly biopesticides based on botanical resources.
Fast Power Estimation of Large Circuits

Our new technique for estimating transition probabilities of internal signals in combinational circuits uses Markov chains and reconvergence regions. To efficiently implement the computation, we use ROBDDs (reduced, ordered binary decision diagrams). Accounting for temporal dependence of signals, multiple concurrent transitions, and mutual dependence of internal signals, the technique provides an exact computation for small circuits and an approximate estimate for large circuits. Experimental results show the estimation technique is fast with only small inaccuracies.
Seeing is Predicting: Water Clarity-Based Nowcast Models for E. coli Prediction in Surface Water

Given the 24–48 h turn-around time of conventional surveillance approaches, methods are needed that improve the timeliness and accuracy of recreational water quality risk assessments. Although one useful approach is to combine existing monitoring programmes with predictive faecal indicator bacteria (FIB) models, these models are largely ‘top-down’ in their approach to safeguarding public health. Beyond being simply ‘advised when to avoid swimming’, there is an increasing awareness amongst the general public regarding the role they can play in water quality monitoring. Using quantile, maximum value and optimized incremental modelling approaches, this study reports on the possibility of developing intuitive, public-friendly models that are based on the physical appearance of water (clarity), to estimate 8103 nation-wide E. coli concentrations in rivers, and to assess whether water is safe to swim in. If swimmers were to avoid river waters with <1.1 m black disc visibility during autumn and summer, and river waters with values <0.5 m black disc visibility during spring and winter, they would also avoid microbial hazards that are associated with exceedances of the 540 CFU/100 mL single sample bathing water standard. Regardless of the climatic season, stream order classification, catchment land cover or geology of streams considered, the clarity-based E. coli models performed well as they presented with sensitivity, specificity and accuracy values of at least 72%. The developed models offer the benefit of providing a faster method for estimating E. coli concentration, potentially engaging the public in water monitoring, and allowing them to make informed decisions on whether it is safe to swim.
Research on the Segmentation of MRI Image Based on Multi-Classification Support Vector Machine

In head MRI image, the boundary of each encephalic tissue is highly complicated and irregular. It is a real challenge to traditional segmentation algorithms. As a new kind of machine learning, support vector machine (SVM) based on statistical learning theory (SLT) has high generalization ability, especially for dataset with small number of samples in high dimensional space. SVM was originally developed for two-class classification. It is extended to solve multi-class classification problem. In this paper, 57 dimensional feature vectors for MRI image are selected as input for SVM. The segmentation of MRI image based on the multi-classification SVM (MCSVM) is investigated. As our experiment demonstrates, the boundaries of 7 kinds of encephalic tissues are extracted successfully, and it can reach satisfactory generalization accuracy. Thus, SVM exhibits its great potential in image segmentation.
C1-Esterase inhibitor: an anti-inflammatory agent and its potential use in the treatment of diseases other than hereditary angioedema.

C1-esterase inhibitor (C1-Inh) therapy was introduced in clinical medicine about 25 years ago as a replacement therapy for patients with hereditary angioedema caused by a deficiency of C1-Inh. There is now accumulating evidence, obtained from studies in animals and observations in patients, that administration of C1-Inh may have a beneficial effect as well in other clinical conditions such as sepsis, cytokine-induced vascular leak syndrome, acute myocardial infarction, or other diseases. Activation of the complement system, the contact activation system, and the coagulation system has been observed in these diseases. A typical feature of the contact and complement system is that on activation they give rise to vasoactive peptides such as bradykinin or the anaphylatoxins, which in part explains the proinflammatory effects of either system. C1-Inh, belonging to the superfamily of serine proteinase inhibitors (serpins), is a major inhibitor of the classical complement pathway, the contact activation system, and the intrinsic pathway of coagulation, respectively. It is, therefore, endowed with anti-inflammatory properties. However, inactivation of C1-Inh occurs locally in inflamed tissues by proteolytic enzymes (e.g., elastase) released from activated neutrophils or bacteria thereby leading to increased local activation of the various host defense systems. Here we will give an overview on the biochemistry and biology of C1-Inh. We will discuss studies addressing therapeutic administration of C1-Inh in experimental and clinical conditions. Finally, we will provide an explanation for the therapeutic benefit of C1-Inh in so many different diseases.
Small intestinal permeability in older adults

It is not yet clear whether intestinal mucosal permeability changes with advancing age in humans. This question is of high importance for drug and nutrition approaches for older adults. Our main objective was to answer the question if small intestinal barrier integrity deteriorates with healthy aging. We conducted a cross‐sectional study including the pooled data of 215 nonsmoking healthy adults (93 female/122 male), 84 of whom were aged between 60 and 82 years. After a 12‐h fast, all participants ingested 10 g of lactulose and 5 g of mannitol. Urine was collected for 5 h afterwards and analyzed for test sugars. The permeability index (PI = lactulose/mannitol) was used to assess small intestinal permeability. Low‐grade inflammation defined by high‐sensitivity C‐reactive protein ≥1 mL/L and kidney function (estimated glomerular filtration rate) were determined in the older age group. The PI was similar in older compared to younger adults (P = 0.887). However, the urinary recovery of lactulose and mannitol was lower in the older adults and this change was neither associated with urinary volume nor glomerular filtration rate. The PI was not significantly correlated with low‐grade inflammation or presence of noninsulin‐dependent type 2 diabetes. However, it significantly deteriorated in the copresence of both conditions compared to low‐grade inflammation alone (P = 0.043) or type 2 diabetes alone (P = 0.015). Small intestinal mucosal barrier does not deteriorate with age per se. But low‐grade inflammation coupled with minor disease challenges, such as type 2 diabetes, can compromise the small intestinal barrier.
Circadian Cycle and Its Influence on Parameters of Aerobic Training

Objectives: This study aims to evaluate the Influence of two distinct Periods of the day on maximal aerobic power in young Athletes mountain bike. Volunteers are the mountain bike Athletes, 37.83 ± 8.87 years, and underwent two progressive maximal exercise test on a cycle Ergometer at two times of day. Gauging the behavior glucose and heart rate. The verification of normality of data was performed by the Shapiro-Wilk test for analysis of variables was Adopted t test for paired samples. Statistical we Adopted an evidence for p <0.05. Results: Were the glucose threshold results not statistically significant. However trends indicating were there a better outcome in the evening. The maximal workload, maximal heart rate and glycemic load threshold. Conclusions: The results show trends on performance and circadian rhythm, and yet, the routine or team chosen for sensivity training appears to the circadian cycle.
Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhage.

OBJECT Matrix metalloproteinases (MMPs) are overexpressed in the presence of some neurological diseases in which blood-brain barrier disruption exists. The authors investigated the MMP-9 concentration in patients after acute intracerebral hemorrhage (ICH) and its relation to perihematomal edema (PHE). METHODS Concentrations of MMP-9 and related proteins were determined in plasma by performing an enzyme-linked immunosorbent assay of samples drawn after hospital admission (< 24 hours after stroke) from 57 patients with ICH. The diagnosis of ICH was made on the basis of findings on computerized tomography (CT) scans. The volumes of ICH and PHE were measured on baseline and follow-up CT scans at the same time that the patient's neurological status was assessed using the Canadian Stroke Scale and the Glasgow Coma Scale. Increased expression of MMP-9 was found among patients with ICH. In cases of deep ICH, MMP-9 was significantly associated with PHE volume (r = 0.53; p = 0.01) and neurological worsening (237.4 compared with 111.3 ng/ml MMP-9; p = 0.04). A logistic regression model focusing on the study of absolute PHE volume showed ICH volume as an independent predictor (odds ratio [OR] 3.37; 95% confidence interval [CI] 1.1-10.3; p = 0.03). A second analysis of relative PHE volume (absolute PHE volume/ICH volume) in patients with deep ICH demonstrated that the only factor related to it was MMP-9 concentration (OR 11.6; 95% CI 1.5-89.1; p = 0.018). CONCLUSIONS Expression of MMP-9 is raised after acute spontaneous ICH. Among patients with deep ICH this increase is associated with PHE and the development of neurological worsening within the acute stage.