Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnostic accuracy of the protein/creatinine ratio in urine samples to estimate 24-h proteinuria in patients with primary glomerulopathies: a longitudinal study.

BACKGROUND The protein/creatinine (P/C) ratio in urine samples has been used in the clinical management of patients with glomerular diseases. The aim of this study is to perform a prospective evaluation of the P/C ratio accuracy in determining critical levels of proteinuria in patients with glomerulopathies. METHODS This is a longitudinal study of 41 adult patients with primary glomerulopathies treated with immunosuppressive drugs or angiotensin-converting enzyme inhibitors in a 6-month follow-up. Correlation and agreement level between P24 and the P/C ratio were evaluated. Kappa statistic was employed to evaluate concordance between the two methods taking into account clinically relevant categories of proteinuria. ANOVA for repeated measures was employed. Diagnostic accuracy of the P/C ratio was evaluated by receiver-operator curves (ROC). RESULTS There was a significant correlation between P24 and the P/C ratio during the 6-month period (P < 0.001 in all time points). Mean differences between P24 and P/C ratios at baseline and from the first to the sixth month were 2.00, 1.88, 1.22, 1.07, 0.65, 0.34 and 0.57 respectively. In spite of the lower agreement between P24 and the P/C ratio for higher levels of proteinuria, we found substantial Kappa values for categories of proteinuria in all periods. ROC considering the cut-off levels of 0.20 g and 3.5 g for P24 showed that the P/C ratio had a very good accuracy, with areas under the curve of 0.99 (95% CI: 0.97-1.00) and 0.99 (95% CI: 0.99-1.00), respectively. CONCLUSION This longitudinal analysis corroborates the findings of previous cross-sectional studies, supporting the use of the P/C ratio as an accurate test to define critical levels of proteinuria.
Bacterial community and biological nitrate removal: comparisons of autotrophic and heterotrophic reactors for denitrification with raw sewage.

An autotrophic denitrification reactor (ADR-1) and a heterotrophic denitrification reactor (HDR-2) were operated to remove nitrate and nitrite in an anoxic environment in raw sewage. The NO3-N removal rate of ADR-1 was shown to range from 52.8% to 78.7%, which was higher than the NO3-N removal rate of HDR-2. Specific denitrification rates (SDNR) of ADR-1 and HDR-2 were 3.0 to 4.0 and 1.1 to 1.2mgNO3- N/gVSS/h, respectively. From results of restriction fragment length polymorphism (RFLP) of the 16S rRNA gene, Aquaspirillum metamorphum, Alcaligenes defragrans, and Azoarcus sp. were beta-Proteobacteria that are affiliated with denitrifying bacteria in the ADR-1. Specifically, Thiobacillus denitrificans was detected as an autotrophic denitrification bacteria. In HDR-2, the beta-Proteobacteria such as Denitrifying- Fe-oxidizing bacteria, Alcaligenes defragrans, Acidovorax sp. , Azoarcus denitrificans, and Aquaspirillum metamorphum were the main bacteria related to denitrifying bacteria. The beta-and alpha-Proteobacteria were the important bacterial groups in ADR-1, whereas the beta-Proteobacteria were the main bacterial group in HDR-2 based on results of fluorescent in situ hybridization (FISH). The number of Thiobacillus denitrificans increased in ADR-1 during the operation period but not in HRD-2. Overall, the data presented here demonstrate that many heterotrophic denitrifying bacteria coexisted with autotrophic denitrifying bacteria such as Thiobacillus denitrificans for nitrate removal in ADR-1. On the other hand, only heterotrophic denitrifying bacteria were identified as dominant bacterial groups in HDR-2. Our research may provide a foundation for the complete nitrate removal in raw sewage of low-COD concentration under anoxic condition without any external organic carbon or the requirement of post-treatment.
The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals

Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable in vivo using magnetic resonance imaging. It is not clear whether abnormalities of cortical anatomy in AD can be reliably measured across different subject samples, how closely they track symptoms, and whether they are detectable prior to symptoms. An exploratory map of cortical thinning in mild AD was used to define regions of interest that were applied in a hypothesis-driven fashion to other subject samples. Results demonstrate a reliably quantifiable in vivo signature of abnormal cortical anatomy in AD, which parallels known regional vulnerability to AD neuropathology. Thinning in vulnerable cortical regions relates to symptom severity even in the earliest stages of clinical symptoms. Furthermore, subtle thinning is present in asymptomatic older controls with brain amyloid binding as detected with amyloid imaging. The reliability and clinical validity of AD-related cortical thinning suggests potential utility as an imaging biomarker. This “disease signature” approach to cortical morphometry, in which disease effects are mapped across the cortical mantle and then used to define ROIs for hypothesis-driven analyses, may provide a powerful methodological framework for studies of neuropsychiatric diseases.
Aspek pengurusan program latihan dan kesannya terhadap kepuasan atlet sekolah sukan

Kajian ini bertujuan untuk mengenal pasti kesan aspek Pengurusan Program Latihan terhadap kepuasan atlet sekolah sukan.Seramai 206 orang atlet dari dua buah sekolah sukan di Malaysia telah dipilih menggunakan persampelan rawak sebagai responden kajian. Kajian ini ialah satu kajian kuantitatif yang menggunakan kaedah tinjauan untuk menjawab objektif kajian.Satu set soal selidik telah digunakan dalam kajian ini berdasarkan Athlete Satisfaction Questionnaire (ASQ) oleh Reimer dan Chelladurai (1998) sementara bagi Pengurusan Program Latihan Jurulatih (PPLJ) oleh Anuar (2010). Analisis statistic inferens seperti ujian t, Korelasi Pearson dan Regresi Pelbagai digunakan untuk menguji lima hipotesis nol pada aras signifi kan p < 0.05. Program yang digunakan untuk menganalisis data ialah program SPSS versi 20. Dapatan kajian menunjukkan terdapat hubungan yang positif dan signifi kan (r = 0.548, p < 0.05) antara Pengurusan Program Latihan Jurulatih dengan kepuasan atlet.Selain daripada itu, aspek pengetahuan jurulatih, aspek kemudahan dan fasiliti serta aspek program latihan merupakan pengaruh Pengurusan Program Latihan jurulatih yang utama terhadap kepuasan atlet.Para jurulatih perlu merangka program latihan selaras dengan perkembangan Sains Sukan moden tanpa melupakan aspek fasiliti dan kemudahan.Teknologi moden dalam fasiliti dan kemudahan harus digunakan oleh jurulatih dan atlet dengan mengurangkan pendekatan secara tradisional.
Combined analysis of myocardial function, viability, and stress perfusion in patients with chronic total occlusion in relation to collateral flow.

BACKGROUND Indications for revascularisation in chronic total occlusion (CTO) of the coronary artery depend on the interplay between myocardial function, viability, and ischaemia. The technical feasibility of the procedure often relies on the collateral flow to the occluded artery. AIM To assess the relation between the degree of collateral flow and characteristics of the myocardium supplied by the oc-cluded artery. METHODS The study included 54 patients (mean age 62 years, 85% males) with CTO referred for cardiovascular magnetic resonance (CMR) to assess indications for revascularisation. The presence of well-developed collateral flow was defined as a collateral connection grade = 2 and Rentrop score = 3. RESULTS The presence of well-developed collaterals (n = 24, 44%) was less likely to be related to systolic dysfunction of the segments supplied by the occluded artery (mean wall motion score index 1.31 ± 0.44 vs. 1.64 ± 0.67, p = 0.04) in comparison to a lack of well-developed collaterals. Patients with well-developed collaterals had a lower frequency of previous myocar-dial infarction of the CTO territory (38% vs. 67%, p = 0.03) with similar frequency of transmural infarctions (21% vs. 23%, p = 0.83). They less frequently presented perfusion deficits of the CTO area during hyperaemia (42% vs. 70%, p = 0.03) and the size of deficits was smaller (median 0.0% [interquartile range 0-12%] vs. 7.5% [0-15%], p = 0.04). CONCLUSIONS Myocardial segments supplied by CTO with well-developed collaterals are less prone to inducible ischaemia, have better systolic function, and are less likely to undergo myocardial infarction, in comparison to those supplied by CTO with poor collateral circulation. CMR is a non-invasive method that can be used for a comprehensive workup of patients be-ing considered for CTO revascularisation.
Autoimmune hepatitis: focusing on treatments other than steroids.

BACKGROUND Corticosteroid therapy has been the time-honoured treatment for autoimmune hepatitis; however, the emergence of new immunosuppressive agents has afforded opportunities to improve or replace the standard regimens. OBJECTIVE To describe technological advances and feasible treatment interventions that promise to supplant the current generation of corticosteroids. METHODS A review of the MEDLINE database for published experiences from 1984 to 2011 was conducted. RESULTS Cyclosporine and tacrolimus have been uniformly successful as salvage therapies for steroid-refractory autoimmune hepatitis. Ten reports of cyclosporine therapy involving 133 patients had positive outcomes in 93%, whereas therapy with tacrolimus in three reports involving 41 patients had positive outcomes in 98%. Salvage therapy with mycophenolate mofetil had a favourable outcome in 47%, especially in patients with azathioprine intolerance. Front-line therapy with mycophenolate mofetil normalized liver parameters in 88% and allowed corticosteroid tapering in 58%. Front-line therapy with budesonide combined with azathioprine for six months normalized liver parameters more frequently (47% versus 18%) and with fewer side effects (28% versus 53%) than prednisone combined with azathioprine. Monoclonal antibodies to CD3 and recombinant cytotoxic T lymphocyte antigen 4 fused with immunoglobulin represent feasible molecular interventions for study in autoimmune hepatitis. DISCUSSION Nonstandard drug therapies must be used in highly selected clinical situations including steroid failure (calcineurin inhibitors), azathioprine intolerance (mycophenolate mofetil), and mild disease or fragile patients (budesonide combined with azathioprine). Molecular interventions for autoimmune hepatitis are feasible for study because of their use in other immune-mediated diseases. CONCLUSION Opportunities to improve or replace standard corticosteroid regimens have emerged.
STRUCTURAL ENCODING AND IDENTIFICATION IN FACE PROCESSING: ERP EVIDENCE FOR SEPARATE MECHANISMS

The present study had two aims. The first aim was to explore the possible top-down effect of face-recognition and/or face-identification processes on the formation of structural representation of faces, as indexed by the N170 ERP component. The second aim was to examine possible ERP manifestations of face identification processes as an initial step for assessing their time course and functional neuroanatomy. Identical N170 potentials were elicited by famous and unfamiliar faces in Experiment 1, when both were irrelevant to the task, suggesting that face familiarity does not affect structural encoding processes. Small but significant differences were observed, however, during later-occurring epochs of the ERPs. In Experiment 2 the participants were instructed to count occasionally occurring portraits of famous politicians while rejecting faces of famous people who were not politicians and faces of unfamiliar people. Although an attempt to identify each face was required, no differences were found in the N170 elicited by faces of unfamiliar people and faces of familiar non-politicians. Famous faces, however, elicited a negative potential that was significantly larger than that elicited by unfamiliar faces between about 250 and 500msec from stimulus onset. This negative component was tentatively identified as an N400 analogue elicited by faces. Both the absence of an effect of familiarity on the N170 and the familiarity face-N400 effect were replicated in Experiment 3, in which the participants made speeded button-press responses in each trial, distinguishing among faces of politicians and faces of famous and unfamiliar non-politicians. In addition, ERP components later than the N400 were found to be associated with the speed of the response but not with face familiarity. We concluded that (1) although reflected by the N170, the structural encoding mechanism is not influenced by the face recognition and identification processes, and (2) the negative component modulated by face familiarity is associated with the semantic activity involved in the identification of familiar faces.
Développement et validation d'un outil clinique pour l'analyse quantitative de la posture auprès de personnes atteintes d'une scoliose idiopathique

Idiopathic scoliosis (IS) is characterized by three-dimensional (3D) deformity of the spine and rib cage which can increase during growth. The morphologic changes of the trunk result in posture asymmetries. Correction of posture is an important goal of physiotherapy interventions among persons with IS to prevent scoliosis progression, to reduce morphologic deformities and their impact on quality of life. Currently, there are no tools that globally quantify changes in posture that may be attributable to scoliosis progression or to treatment effectiveness, that are usable in a clinical setting. The objective of this thesis was thus to develop and validate a new clinical quantitative posture assessment tool among persons with IS. More specifically, this project aims to determine reliability and concurrent validity of posture indices (PI) of this new tool and to verify their capacity to detect changes between standing and sitting positions. We conducted a literature review and selected 34 PI representing frontal and sagittal alignment of the different body segments. We constructed a software-based quantitative posture assessment tool to calculate different PI (angular and linear measurements). The software has a user-friendly graphical interface and allows calculation of PI from a set of markers selected interactively on digital photographs. For the reliability and validity studies, standing posture of 70 participants aged 10 to 20 years old with IS (Cobb angle: 15o to 60o) was assessed on two occasions by two physiotherapists. Markers placed on several bony landmarks as well as natural reference points (eyes, ear lobe, etc.) were used to measure the PI from photographs with the 2D tool and to calculate 3D PI obtained from trunk reconstructions with a surface topography system. Frontal and sagittal Cobb angles and trunk list were also calculated on radiographs. The generalizability theory was used to estimate the reliability and standard error of measurement (SEM) of PI of the 2D tool. Pearson correlation coefficients served to estimate concurrent validity of the 2D trunk PI with corresponding 3D PI and with those obtained from radiographs. Fifty participants were assessed for the comparative study
Abstract Principles and Concrete Cases in Intuitive Lawmaking

Principles and Concrete Cases in Intuitive Lawmaking Ira Mark Ellman • Sanford L. Braver • Robert J. MacCoun American Psychology-Law Society/Division 41 of the American Psychological Association 2011 Abstract Citizens awaiting jury service were asked a series of items, in Likert format, to determine theirCitizens awaiting jury service were asked a series of items, in Likert format, to determine their endorsement of various statements about principles to use in setting child support amounts. These twenty items were derived from extant child support systems, from past literature and from Ellman and Ellman’s (2008) Theory of Child Support. The twenty items were found to coalesce into four factors (principles). There were pervasive gender differences in respondent’s endorsement of the principles. More importantly, three of these four principles were systematically reflected, in very rational (if complex) ways, in the respondents’ resolution of the individual child support cases they were asked to decide. Differences among respondents in their endorsement of these three principles accounted for differences in their patterns of child support judgments. It is suggested that the pattern of coherent arbitrariness (Ariely et al., Q J Econ 118(1):73–105, 2003) in those support judgments, noted in an earlier study (Ellman, Braver, & MacCoun, 2009) is thus partially explained, in that the seeming arbitrariness of respondents’ initial support judgments reflect in part their differing views about the basic principles that should decide the cases.
A theory of statistical models for Monte Carlo integration

Summary. The task of estimating an integral by Monte Carlo methods is formulated as a statistical model using simulated observations as data. The difficulty in this exercise is that we ordinarily have at our disposal all of the information required to compute integrals exactly by calculus or numerical integration, but we choose to ignore some of the information for simplicity or computational feasibility. Our proposal is to use a semiparametric statistical model that makes explicit what information is ignored and what information is retained. The parameter space in this model is a set of measures on the sample space, which is ordinarily an infinite dimensional object. None‐the‐less, from simulated data the base‐line measure can be estimated by maximum likelihood, and the required integrals computed by a simple formula previously derived by Vardi and by Lindsay in a closely related model for biased sampling. The same formula was also suggested by Geyer and by Meng and Wong using entirely different arguments. By contrast with Geyer's retrospective likelihood, a correct estimate of simulation error is available directly from the Fisher information. The principal advantage of the semiparametric model is that variance reduction techniques are associated with submodels in which the maximum likelihood estimator in the submodel may have substantially smaller variance than the traditional estimator. The method is applicable to Markov chain and more general Monte Carlo sampling schemes with multiple samplers.
The fate of Cu, Zn, Pb and Cd during the pyrolysis of sewage sludge at different temperatures

In the present study, a sequential extraction procedure, recommended by the Community Bureau of Reference (BCR), was used for the fractionation of the heavy metals Cu, Zn, Pb and Cd in sewage sludge and its residues produced after pyrolysis at different temperatures from 250 to 700 °C. The results show that, in the sludge sample, the sum of the percentages of the reducible and oxidizable fractions for all metals except Cu was very high (65.4% for Cd, 85.7% for Pb, 78.7% for Zn), whereas the sum of the percentages of the oxidizable and residual fractions for Cu was very high (88.8%). The same result could be attained in the residues. Statistical analysis shows that at low temperatures the variation in pyrolysis temperature did not effectively contribute to the distribution of metal speciation in the residues. Meanwhile a modified Toxicity Characteristic Leaching Procedure (TCLP) was employed to determine the leachability of these four metals. The result indicates that the TCLP concentration of Cu, Zn, Pb and Cd dropped sharply after the temperature reached 350 °C, 550 °C, 500 °C and 400 °C respectively, which means pyrolysis can enhance the stability of these four metals when the temperature is high enough.
Semicarbazide‐sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes‐like complications

Semicarbazide‐sensitive amine oxidases (SSAO) are copper‐containing enzymes that oxidatively deaminate primary amines to produce hydrogen peroxide, ammonium, and specific aldehydes. Vascular adhesion protein‐1 (VAP‐1) is a cell surface and soluble molecule that possesses SSAO activity. VAP‐1 protein, SSAO activity, and SSAO reaction products are elevated in the serum of patients with diabetes, congestive heart failure, and specific inflammatory liver diseases. By expressing human VAP‐1/SSAO on mouse endothelial cells and subsequently in the serum, and by chronically treating the transgenic mice for 15 months with a high‐fat diet and a physiological substrate for SSAO, methylamine, the in vivo roles of SSAO were assessed. The VAP‐1 transgene increased the mouse body mass index and subcutaneous abdominal fat pad weights in a manner independent of food consumption. The transgene together with increased SSAO substrate availability enhanced glucose uptake in an SSAO‐dependent manner. The increased SSAO activity also led to diabetes‐like complications, including advanced glycation end product formation, elevated blood pressure, altered atherosclerosis progression, and nephropathy. These findings suggest that, although manipulation of VAP‐1/SSAO has potential to serve as a therapeutic treatment in insulin‐resistant conditions, care must be taken to fully understand its impact on obesity and vascular damage.
Information Security Policy Compliance: A User Acceptance Perspective

Compliance with information security policies (ISPs) is a key factor in reducing an organization’s information security risks. As such, understanding employees’ compliance behavior with ISPs is an important first step to leverage knowledge worker assets in efforts targeted toward reducing information security risks. This study adapts the Technology Acceptance Model (TAM) to examine users’ behavioral intention to comply with ISPs. The impact of information security awareness on behavioral intentions to comply is also considered in the research model. This is a research in progress, and an instrument is being developed to conduct a survey study to gather data from employees in the banking sector in Jordan.
Detecting Solo Phrases in Music Using Spectral and Pitch-related Descriptors

Abstract In this paper we present an algorithm for segmenting musical audio data. Our aim is to identify solo instrument phrases in polyphonic music. We extract relevant features from the audio to be input into our algorithm. A large corpus of audio descriptors was tested for its ability to discriminate between solo and non-solo sections, which resulted in a subset of five best features. We derived a two-stage algorithm that first creates a set of boundary candidates from local changes of these features and then classifies fixed-length segments according to the desired target classes. The output of the two stages is combined to derive the final segmentation and segment labels. Our system was trained and tested with excerpts from classical pieces and evaluated using full-length recordings, all taken from commercially available audio. We evaluated our algorithm by using precision and recall measurements for the boundary estimation and introduced new evaluation metrics from image processing for the final segmentation. Along with a resulting accuracy of 77%, we demonstrate that the selected features are discriminative for this specific task and achieve reasonable results for the segmentation problem.
Corporate Serial Acquisitions: An Empirical Test of the Learning Hypothesis

Recent empirical papers report a declining trend in the cumulative abnormal return (CAR) of acquirers during an M&A program. Does this necessarily imply that acquiring CEOs are infected by hubris and are not learning from previous mistakes? We first confirm the existence of this declining trend on average. However, we find a positive CAR trend for CEOs likely to be infected by hubris, which is significantly different from the negative trend found for CEOs who are more likely to be rational. We also explore the time between successive deals and find empirical evidence to suggest that many CEOs learn substantially during acquisition programs.