Miracle-dz/UniFAR-FTUs huggingface dataset:
Weight Loss-Associated Induction of Peroxisome Proliferator-Activated Receptor-&agr; and Peroxisome Proliferator–Activated Receptor-&ggr; Correlate With Reduced Atherosclerosis and Improved Cardiovascular Function in Obese Insulin-Resistant Mice

Background—Weight loss in obese insulin-resistant but not in insulin-sensitive persons reduces coronary heart disease risk. To what extent changes in gene expression are related to atherosclerosis and cardiovascular function is unknown. Methods and Results—We studied the effect of diet restriction–induced weight loss on gene expression in the adipose tissue, the heart, and the aortic arch and on atherosclerosis and cardiovascular function in mice with combined leptin and LDL-receptor deficiency. Obesity, hypertriglyceridemia, and insulin resistance are associated with hypertension, impaired left ventricular function, and accelerated atherosclerosis in those mice. Compared with lean mice, peroxisome proliferator–activated receptors (PPAR)-&agr; and PPAR-&ggr; expression was downregulated in obese double-knockout mice. Diet restriction caused a 45% weight loss, an upregulation of PPAR-&agr; and PPAR-&ggr;, and a change in the expression of genes regulating glucose transport and insulin sensitivity, lipid metabolism, oxidative stress, and inflammation, most of which are under the transcriptional control of these PPARs. Changes in gene expression were associated with increased insulin sensitivity, decreased hypertriglyceridemia, reduced mean 24-hour blood pressure and heart rate, restored circadian variations of blood pressure and heart rate, increased ejection fraction, and reduced atherosclerosis. PPAR-&agr; and PPAR-&ggr; expression was inversely related to plaque volume and to oxidized LDL content in the plaques. Conclusions—Induction of PPAR-&agr; and PPAR-&ggr; in adipose tissue, heart, and aortic arch is a key mechanism for reducing atherosclerosis and improving cardiovascular function resulting from weight loss. Improved lipid metabolism and insulin signaling is associated with decreased tissue deposition of oxidized LDL that increases cardiovascular risk in persons with the metabolic syndrome.
LILRB2 Interaction with HLA Class I Correlates with Control of HIV-1 Infection

Natural progression of HIV-1 infection depends on genetic variation in the human major histocompatibility complex (MHC) class I locus, and the CD8+ T cell response is thought to be a primary mechanism of this effect. However, polymorphism within the MHC may also alter innate immune activity against human immunodeficiency virus type 1 (HIV-1) by changing interactions of human leukocyte antigen (HLA) class I molecules with leukocyte immunoglobulin-like receptors (LILR), a group of immunoregulatory receptors mainly expressed on myelomonocytic cells including dendritic cells (DCs). We used previously characterized HLA allotype-specific binding capacities of LILRB1 and LILRB2 as well as data from a large cohort of HIV-1-infected individuals (N = 5126) to test whether LILR-HLA class I interactions influence viral load in HIV-1 infection. Our analyses in persons of European descent, the largest ethnic group examined, show that the effect of HLA-B alleles on HIV-1 control correlates with the binding strength between corresponding HLA-B allotypes and LILRB2 (p = 10−2). Moreover, overall binding strength of LILRB2 to classical HLA class I allotypes, defined by the HLA-A/B/C genotypes in each patient, positively associates with viral replication in the absence of therapy in patients of both European (p = 10−11–10−9) and African (p = 10−5–10−3) descent. This effect appears to be driven by variations in LILRB2 binding affinities to HLA-B and is independent of individual class I allelic effects that are not related to the LILRB2 function. Correspondingly, in vitro experiments suggest that strong LILRB2-HLA binding negatively affects antigen-presenting properties of DCs. Thus, we propose an impact of LILRB2 on HIV-1 disease outcomes through altered regulation of DCs by LILRB2-HLA engagement.
The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells

Localized tissue hypoxia is a feature of infection and inflammation, resulting in the upregulation of the transcription factors HIF-1 and NFB via inhibition of oxygen sensing hydroxylase enzymes. Previous studies have demonstrated a beneficial role for the hydroxylase inhibitor dimethyloxallyl glycine (DMOG) in inflammatory conditions, including experimental colitis, by regulating the activity of HIF-1 and NFB. We have demonstrated in vivo that pre-treatment with DMOG attenuates systemic LPS-induced activation of the NFB pathway. Furthermore, mice treated with DMOG had significantly increased survival in LPS-induced shock. Conversely, in models of polymicrobial sepsis, DMOG exacerbates disease severity. DMOG treatment of mice promotes M2 polarization in macrophages within the peritoneal cavity, resulting in the downregulation of pro-inflammatory cytokines such as TNF . In addition, in vivo DMOG treatment upregulates IL-10 expression, specifically in the peritoneal B-1 cell population. This study demonstrates cell type specific roles for hydroxylase inhibition in vivo and provides insight into the mechanism underlying the protection conveyed by DMOG in models of endotoxic shock.
Detailed characterization of South African high mineral matter inertinite-rich coals and density fractions and effect on reaction rates with carbon dioxide : macerals, microlithotypes, carbominerites and minerals

An investigation was undertaken to determine the distribution of macerals and minerals in South African Highveld coal deposits as well as density fractions derived from a typical deposit. The corresponding effects on carbon dioxide gasification reaction rates were also studied. Detailed chemical, petrographic and mineral analyses, followed by reactivity measurements and reaction rate modeling were carried out. Coal samples from seven different coal mines and five density separated coal fractions ( 2.0 g.cm-3) were examined. It was found that the coal samples have ash contents in the range 21.6 to 38.8 wt. % and inertinite composition in the range 68 to 84 vol. %. The inertinites consist of high concentrations of semifusinites and inertodetrinite which is characteristic of South African Highveld coal deposits. The distribution of macerals and minerals in the different density fractions revealed high concentrations of inert inertodetrinite, carbominerite and ash in the dense fraction. The presence of carbominerites was also found to increase with mineral content within the density range of 1.4 g.cm-3 to 1.8 g.cm-3. The random pore model described the gasification reactivity very well with an increasing intrinsic reaction rate correlating with an increasing density of the coal which is attributed to an increasing pre-exponential factor.
The Quiet Revolution: Changes in Educational Criteria, Placement and Programming for the Mildly Retarded.

ABSTRACT Over the past ten years, dramatic changes have been seen in the numbers of mildly mentally retarded students in the United States; in particular, a 30 percent decrease in the number of mildly mentally retarded students between 1976 and 1986 has been well documented. These changes have occurred in response to litigation in the federal courts, concerns about the fundamental nature of mental retardation (particularly whether persons from "adverse" socioeconomic circumstances can be classified as mildly mentally retarded), and disputes about the nature and meaning of adaptive behavior. Two issues are critical in the changing status and diagnosis and treatment of the mildly mentally retarded. The first is the fundamental meaning of the diagnostic construct of mild mental retardation, and the second is the outcome of special education programs for students classified as mildly mentally retarded. This issue of outcomes may be addressed more effectively in current special education reforms, through use of evidence from follow-up studies to design curricula, and in basic research on cognitive modifiability. These trends may lead to the development of more effective programs in the future which make genuine differences in the capabilities of persons who used to be, and in some cases still are, classified as mildly mentally retarded. A list of 40 references is appended. (CB)
Demonstration by immunoelectro-osmophoresis of precipitating antibodies to a purified rubella virus antigen

The nonionic detergent Triton X-100 was used to extract antigens of rubella virus from infected tissue culture cells. Three virus-specific antigens were demonstrated by crossed immunoelectrophoresis by using a pool of human gamma globulin as antiserum. The most dominant of these antigens were purified by ion-exchange chromatography on diethylaminoethyl-cellulose. This antigen was of glucoprotein nature and had slow electrophoretic motility and low binding capacity to diethylaminoethyl-cellulose. Thus, it seems likely that the antigen is identical with the precipitating antigen of rubella virus designated b-antigen or tro-osmophoresis with precipiting antibody in sera obtained from patients recovering from acute postnatal rubella. The precipitin reaction that could be correlated to the hemaglutination-inhibition titers of the same sera appeared 12 days after onset of the disease and remained positive for several years.
Methylation of ELOVL2 gene as a new epigenetic marker of age

The discovery of biomarkers able to predict biological age of individuals is a crucial goal in aging research. Recently, researchers' attention has turn toward epigenetic markers of aging. Using the Illumina Infinium HumanMethylation450 BeadChip on whole blood DNA from a small cohort of 64 subjects of different ages, we identified 3 regions, the CpG islands of ELOVL2, FHL2, and PENK genes, whose methylation level strongly correlates with age. These results were confirmed by the Sequenom's EpiTYPER assay on a larger cohort of 501 subjects from 9 to 99 years, including 7 cord blood samples. Among the 3 genes, ELOVL2 shows a progressive increase in methylation that begins since the very first stage of life (Spearman's correlation coefficient = 0.92) and appears to be a very promising biomarker of aging.
Structure and properties of transition fronts in accretion discs

ABSTRA C T We use high-resolution time-dependent numerical simulations of accretion discs around white dwarfs to study the structure and properties of transition fronts in the context of the thermal‐ viscous disc instability model. The thermal structure of cooling and heating fronts is dominated by radiative cooling and viscous heating, respectively, except in a very narrow precursor region in heating fronts where advection and radial transport of energy dominate. Cooling fronts are much broader than heating fronts, but the widths of both types of fronts scale with the local vertical scaleheight of the disc. We confirm that during a fair fraction of the propagation time of a cooling front, the structure of the inner disc is close to self-similar. The speed of heating fronts is , a few km s ˇ1 , while the speed of cooling fronts is , a fraction of ak m s ˇ1 . We show that direct measurements of the speed of transition fronts probably cannot discriminate between various prescriptions proposed for the viscosity parameter a. A natural prediction of the disc instability model is that fronts decelerate as they propagate in the disc, independent of the prescription for a. Observation of this effect would confirm that dwarf nova outbursts are driven by the thermal‐viscous instability. Most of our results also apply to lowmass X-ray binaries in which the accreting object is a neutron star or a black hole.
Estimating the Proportion of True Null Hypotheses for Multiple Comparisons

Whole genome microarray investigations (e.g. differential expression, differential methylation, ChlP-Chip) provide opportunities to test millions of features in a genome. Traditional multiple comparison procedures such as familywise error rate (FWER) controlling procedures are too conservative. Although false discovery rate (FDR) procedures have been suggested as having greater power, the control itself is not exact and depends on the proportion of true null hypotheses. Because this proportion is unknown, it has to be accurately (small bias, small variance) estimated, preferably using a simple calculation that can be made accessible to the general scientific community. We propose an easy-to-implement method and make the R code available, for estimating the proportion of true null hypotheses. This estimate has relatively small bias and small variance as demonstrated by (simulated and real data) comparing it with four existing procedures. Although presented here in the context of microarrays, this estimate is applicable for many multiple comparison situations.
Locating Political Parties in Policy Space

Starting from a number of deficiencies in the Comparative Manifestos Project approach to studying left–right policy scales in election programs, an additive model based on the distinction between position and valence issues is proposed. This allows analysis of the policy space in established democracies under the assumption that left and right have different meanings from country to country and over time. The model is illustrated with regard to four Western European countries with different types of party system: Germany, Italy, Sweden and the United Kingdom. Empirical findings affirm that the procedures are workable and that the data generated are capable of yielding detailed information beyond that which previous approaches are able to deliver. In addition, preliminary tests on external validity produce reassuring results.
Fuzzy overlapping communities in networks

Networks commonly exhibit a community structure, whereby groups of vertices are more densely connected to each other than to other vertices. Often these communities overlap, such that each vertex may occur in more than one community. However, two distinct types of overlapping are possible: crisp (where each vertex belongs fully to each community of which it is a member) and fuzzy (where each vertex belongs to each community to a different extent). We investigate the effects of the fuzziness of community overlap. We find that it has a strong effect on the performance of community detection methods: some algorithms perform better with fuzzy overlapping while others favour crisp overlapping. We also evaluate the performance of some algorithms that recover the belonging coefficients when the overlap is fuzzy. Finally, we investigate whether real networks contain fuzzy or crisp overlapping.
Protective Effect of Curcumin on Pulmonary and Cardiovascular Effects Induced by Repeated Exposure to Diesel Exhaust Particles in Mice

Particulate air pollution has been associated with increased risk of cardiopulmonary diseases. However, the underlying mechanisms are not fully understood. We have previously demonstrated that single dose exposure to diesel exhaust particle (DEP) causes lung inflammation and peripheral thrombotic events. Here, we exposed mice with repeated doses of DEP (15µg/animal) every 2nd day for 6 days (a total of 4 exposures), and measured several cardiopulmonary endpoints 48 h after the end of the treatments. Moreover, the potential protective effect of curcumin (the yellow pigment isolated from turmeric) on DEP-induced cardiopulmonary toxicity was assessed. DEP exposure increased macrophage and neutrophil numbers, tumor necrosis factor α (TNF α) in the bronchoalveolar lavage (BAL) fluid, and enhanced airway resistance to methacoline measured invasively using Flexivent. DEP also significantly increased plasma C-reactive protein (CRP) and TNF α concentrations, systolic blood pressure (SBP) as well as the pial arteriolar thrombosis. It also significantly enhanced the plasma D-dimer and plasminogen activator inhibitor-1 (PAI-1). Pretreatment with curcumin by oral gavage (45 mg/kg) 1h before exposure to DEP significantly prevented the influx of inflammatory cells and the increase of TNF α in BAL, and the increased airway resistance caused by DEP. Likewise, curcumin prevented the increase of SBP, CRP, TNF α, D-dimer and PAI-1. The thrombosis was partially but significantly mitigated. In conclusion, repeated exposure to DEP induced lung and systemic inflammation characterized by TNFα release, increased SBP, and accelerated coagulation. Our findings indicate that curcumin is a potent anti-inflammatory agent that prevents the release of TNFα and protects against the pulmonary and cardiovascular effects of DEP.
Clinical decision rules to rule out subarachnoid hemorrhage for acute headache.

IMPORTANCE Three clinical decision rules were previously derived to identify patients with headache requiring investigations to rule out subarachnoid hemorrhage. OBJECTIVE To assess the accuracy, reliability, acceptability, and potential refinement (ie, to improve sensitivity or specificity) of these rules in a new cohort of patients with headache. DESIGN, SETTING, AND PATIENTS Multicenter cohort study conducted at 10 university-affiliated Canadian tertiary care emergency departments from April 2006 to July 2010. Enrolled patients were 2131 adults with a headache peaking within 1 hour and no neurologic deficits. Physicians completed data forms after assessing eligible patients prior to investigations. MAIN OUTCOMES AND MEASURES Subarachnoid hemorrhage, defined as (1) subarachnoid blood on computed tomography scan; (2) xanthochromia in cerebrospinal fluid; or (3) red blood cells in the final tube of cerebrospinal fluid, with positive angiography findings. RESULTS Of the 2131 enrolled patients, 132 (6.2%) had subarachnoid hemorrhage. The decision rule including any of age 40 years or older, neck pain or stiffness, witnessed loss of consciousness, or onset during exertion had 98.5% (95% CI, 94.6%-99.6%) sensitivity and 27.5% (95% CI, 25.6%-29.5%) specificity for subarachnoid hemorrhage. Adding "thunderclap headache" (ie, instantly peaking pain) and "limited neck flexion on examination" resulted in the Ottawa SAH Rule, with 100% (95% CI, 97.2%-100.0%) sensitivity and 15.3% (95% CI, 13.8%-16.9%) specificity. CONCLUSIONS AND RELEVANCE Among patients presenting to the emergency department with acute nontraumatic headache that reached maximal intensity within 1 hour and who had normal neurologic examination findings, the Ottawa SAH Rule was highly sensitive for identifying subarachnoid hemorrhage. These findings apply only to patients with these specific clinical characteristics and require additional evaluation in implementation studies before the rule is applied in routine clinical care.
Treating the Sexual Offender

Introduction The Development of Behavioral Techniques for the Sexual Offender The Initial Assessment of the Sexual Offender - Kevin B McGovern The Aversive Respondent Conditioning Techniques The Reconditioning Techniques The Positive Respondent Conditioning Techniques The Operant Conditioning Techniques Adjunctive Techniques The Somatic Therapies Homework Assignments Data Generated by an Outpatient Sexual Abuse Clinic Summary and Future Directions
PERSONALITY CHARACTERISTICS OF INNOVATIVE PHYSICS TEACHERS.

Innovative physics teachers scored higher on theoretical and aesthetic values than other male high school teachers, but lower on economic, religious, and political values. The innovative teachers scored much higher on a physics achievement test than physics teachers in three summer institutes. While they are close to the norm for male secondary school teachers on teaching attitudes, they have a lower need for affiliation than this group. Compared with other male high-school science teachers, they are less abasing and affiliative, but more autonomous and heterosexual. Because of their relatively high intellectual and artistic values, and needs for autonomy and social independence, their profiles resemble those of creative scientists. Two personality variables suggesting a “warm, outgoing teaching attitude factor” are significantly correlated with the teachers' knowledge of physics. The teachers who have a firm grasp of their subject not only have more positive attitudes toward teaching, but appear to be less intraceptive.
Human rights, transnational actors and the Chinese government: Another look at the spiral model

This article assesses the usefulness of Thomas Risse, Stephen Ropp and Kathryn Sikkink's spiral model as an explanation of the changes in the Chinese government's human rights practices from the time of the ‘anti-rightist’ campaign in 1957–1958 to the end of 2003. It is concluded that the spiral model has provided a valid explanation for many of the changes in the Chinese government's human rights practices, and its responses to its internal and external critics, over this time period. Many of the responses of the transnational human rights network and the Chinese government by the end of this period indicate that the latter had progressed to phase three of the model. It is also concluded that the spiral model only conceptualises part of the constitutive relationship between the target state and international human rights norms—the influence of these norms on the identities, interests and behaviours of a target state. It does not conceptualise the influence of a target state on international human rights norms or the transnational human rights network. Therefore, the spiral model cannot explain why the Chinese government has had such a significant influence over the enforcement mechanisms of these norms.
Tidally Triggered Star Formation in Close Pairs of Galaxies

We analyze optical spectra of a sample of 502 galaxies in close pairs and N-tuples, separated by ≤50 h-1 kpc. We extracted the sample objectively from the CfA2 redshift survey, without regard to the surroundings of the tight systems; we remeasure the spectra with longer exposures, to explore the spectral characteristics of the galaxies. We use the new spectra to probe the relationship between star formation and the dynamics of the systems of galaxies. The equivalent widths of Hα [EW(Hα)] and other emission lines anticorrelate strongly with pair spatial separation (ΔD) and velocity separation; the anticorrelations do not result from any large-scale environmental effects that we detect. We use the measured EW(Hα) and the starburst models of Leitherer et al. to estimate the time since the most recent burst of star formation began for galaxies in our sample. In the absence of a large contribution from an old stellar population to the continuum around Hα that correlates with the orbit parameters, the observed ΔD-EW(Hα) correlation signifies that starbursts with larger separations on the sky are, on average, older. We also find a population of galaxies with small to moderate amounts of Balmer absorption. These galaxies support our conclusion that the sample includes many aging bursts of star formation; they have a narrower distribution of velocity separations, consistent with a population of orbiting galaxies near apogalacticon. By matching the dynamical timescale to the burst timescale, we show that the data support a simple picture in which a close pass initiates a starburst; EW(Hα) decreases with time as the pair separation increases, accounting for the anticorrelation. Recent N-body/smoothed particle hydrodynamics simulations of interacting pairs suggest a physical basis for the correlation—for galaxies with shallow central potentials, they predict gas infall before the final merger. This picture leads to a method for measuring the duration and the initial mass function of interaction-induced starbursts: our data are compatible with the starburst models and orbit models in many respects, as long as the starburst lasts longer than ~108 yr and the delay between the close pass and the initiation of the starburst is less than a few times 107 yr. If there is no large contribution from an old stellar population to the continuum around Hα, the Miller-Scalo and cutoff (M ≤ 30 M☉) Salpeter initial mass functions (IMFs) fit the data much better than a standard Salpeter IMF.