Miracle-dz/UniFAR-FTUs huggingface dataset:
Symptom response and side-effects of olanzapine and risperidone in young adults with recent onset schizophrenia

The symptom response and side-effects of olanzapine and risperidone were compared in patients with recent onset schizophrenia. Actively symptomatic patients (n=44) randomly received olanzapine 15 mg (median dose) or risperidone 4 mg (median dose). Symptom response and side-effects were measured during a 6–10-week treatment study. No major differences were observed between the two treatment groups. Symptoms improved significantly on the Positive and Negative Syndrome Scale total score, positive subscale and general psychopathology subscale for both treatment groups. Using five symptom dimensions, both drugs were effective in treating positive symptoms and agitation/excitement symptoms, and neither olanzapine or risperidone influenced disorganization and depression symptoms. Results on the negative symptoms subscale and symptom dimension were inconclusive. No major differences were found in the frequency of the reported side-effects akathisia, parkinsonism and weight gain. These data indicate that the differences between olanzapine and risperidone in symptom response are small. In spite of the relatively low power of the study, we could exclude the presence of substantially different treatment effects between olanzapine and risperidone.
Beyond the four walls: community-based learning and languages

At a time when languages in universities are under pressure, community-based learning language courses can have many positive benefits: they can increase interest in language learning, they can foster greater engagement with learning, and they can encourage active learning, creativity and teamwork. These courses, which link the classroom and the community, help address needs in the community, share resources and make languages more visible. By giving students the opportunity to engage in practical work, their transferable skills are enhanced. The gap between the university and community is closed and positive attitudes towards language learning are fostered. This paper examines research into community-based learning and language courses and the effect that the approach has on students. Using an example of such a course in NUI Galway, the author gives voice to the student experience of a CBL course and its impact on their motivation, their style of learning and their attitudes towards language learning. Finally, a template for the introduction of such a course is proposed which guides instructors through the central elements in the design, implementation and evaluation of a CBL course.
Heart rate recovery: a practical clinical indicator of abnormal cardiac autonomic function

The autonomic nervous system (ANS) and cardiovascular function are intricately and closely related. One of the most frequently used diagnostic and prognostic tools for evaluating cardiovascular function is the exercise stress test. Exercise is associated with increased sympathetic and decreased parasympathetic activity and the period of recovery after maximum exercise is characterized by a combination of sympathetic withdrawal and parasympathetic reactivation, which are the two main arms of the ANS. Heart rate recovery after graded exercise is one of the commonly used techniques that reflects autonomic activity and predicts cardiovascular events and mortality, not only in cardiovascular system disorders, but also in various systemic disorders. In this article, the definition, applications and protocols of heart rate recovery and its value in various diseases, in addition to exercise physiology, the ANS and their relationship, will be discussed.
A Life-History Model of Human Fitness Indicators

Recent adaptationist accounts of human mental and physical health have reinvigorated the debate over the evolution of human intelligence. In the tradition of strong inference the current study was developed to determine whether either Miller's (1998, 2000a) Fitness Indicator Theory or Rushton's (1985, 2000) Differential-K Theory better accounts for general intelligence (“g”) in an undergraduate university population (N = 192). Owing to the lengthy administration time of the test materials, a newly developed 18-item short form of the Ravens Advanced Progressive Matrices (APM-18; Sefcek, Miller, and Figueredo 2007) was used. A significant, positive relationship between K and F (r = .31, p < .001) emerged. Contrary to predictions, no significant relationships were found between “g” and either K or F (r = –.09, p ≥ .05 and r = .11, p ≥ .05, respectively). Though generally contrary to both hypotheses, these results may be explained in relation to antagonistic pleiotropy and a potential failure to derive correct predictions for within-species comparisons directly from the results of between-species comparisons.
The use of art within a groupwork setting

As part of the commitment to social approaches in the promotion of mental health and well being, the use of the arts has been increasingly adopted as a means of enhancing the sense of self worth, achievement and creativity amongst participants and as such is regarded as a valid alternative to talking and physical therapies. However, within the mental health field, existing research has tended to focus on psychotherapeutically orientated models of art therapy rather than on the use of art as a therapeutic activity in its own right. Such research has also concentrated on the treatment of pre-existing mental health problems rather than on the issue of prevention. It is therefore the purpose of this article to help to redress this neglect by examining the work of an activity orientated art project and its role in promoting the mental health of ‘at risk’ groups, both in terms of its impact on individual participants as well as on wider group processes.
Performance of Broiler Chickens Fed Low Protein, Limiting Amino Acid Supplemented Diets Formulated Either on Total or Standardized Ileal Digestible Amino Acid Basis

The aim of present experiment was to investigate the effect of protein reduction in commercial broiler chicken rations with incorporation of de-oiled rice bran (DORB) and supplementation of limiting amino acids (valine, isoleucine, and/or tryptophan) with ration formulation either on total amino acid (TAA) or standardized ileal digestible amino acids (SIDAA). The experimental design consisted of T1, TAA control; T2 and T3, 0.75% and 1.5% protein reduction by 3% and 6% DORB incorporation, respectively by replacing soybean meal with supplemental limiting amino acids to meet TAA requirement; T4, SIDAA control, T5 and T6, 0.75% and 1.5% protein reduction by DORB incorporation (3% and 6%) with supplemental limiting amino acids on SIDAA basis. A total of 360 d-old fast growing broiler chicks (Vencobb-400) were divided into 36 homogenous groups of ten chicks each, and six dietary treatments described were allocated randomly with six replications. During 42 days trial, the feed intake was significantly (p<0.05) reduced by TAA factor compared to SIDAA factor and protein factor significantly (p<0.05) reduced the feed intake at 1.5% reduction compared to normal protein group. This was observed only during pre-starter phase but not thereafter. The cumulative body weight gain (BWG) was significantly (p<0.05) reduced in TAA formulations with protein step-down of 1.5% (T3, 1,993 g) compared to control (T1, 2,067 g), while under SIDAA formulations, BWG was not affected with protein reduction of 1.5% (T6, 2,076 g) compared to T4 (2,129 g). The feed conversion ratio (FCR) was significantly (p<0.05) reduced in both TAA and SIDAA formulations with 1.5% protein step-down (T3, 1.741; T6, 1.704) compared to respective controls (T1, 1.696; T4, 1.663). The SIDAA formulation revealed significantly (p<0.05) higher BWG (2,095 g) and better FCR (1.684) compared to TAA formulation (2,028 g; 1.721). Intake of crude protein and all limiting amino acids (SID basis) was higher in SIDAA group than TAA group with resultant higher nitrogen retention (4.438 vs 4.027 g/bird/d). The nitrogen excretion was minimized with 1.5% protein reduction (1.608 g/bird) compared to normal protein group (1.794 g/bird). The serum uric acid concentration was significantly reduced in T3 (9.45 mg/dL) as compared to T4 (10.75 mg/dL). All carcass parameters were significantly (p<0.05) higher in SIDAA formulation over TAA formulation and 1.5% protein reduction significantly reduced carcass, breast and thigh yields. In conclusion, the dietary protein can be reduced by 0.75% with TAA formulation and 1.5% with SIDAA formulation through DORB incorporation and supplementation of limiting amino acids and among formulations, SIDAA formulation was better than TAA formulation.
Steering Behaviors For Autonomous Characters

This paper presents solutions for one requirement of autonomous characters in animation and games: the ability to navigate around their world in a life-like and improvisational manner. These “steering behaviors” are largely independent of the particulars of the character’s means of locomotion. Combinations of steering behaviors can be used to achieve higher level goals (For example: get from here to there while avoiding obstacles, follow this corridor, join that group of characters.) This paper divides motion behavior into three levels. It will focus on the middle level of steering behaviors, briefly describe the lower level of locomotion, and touch lightly on the higher level of goal setting and strategy.
Clindamycin Affects Group A Streptococcus Virulence Factors and Improves Clinical Outcome

Group A Streptococcus (GAS) has acquired an arsenal of virulence factors, promoting life-threatening invasive infections such as necrotizing fasciitis. Current therapeutic regimens for necrotizing fasciitis include surgical debridement and treatment with cell wall-active antibiotics. Addition of clindamycin (CLI) is recommended, although clinical evidence is lacking. Reflecting the current clinical dilemma, an observational study showed that only 63% of the patients with severe invasive GAS infection received CLI. This work thus aimed to address whether CLI improves necrotizing fasciitis outcome by modulating virulence factors of CLI-susceptible and CLI-resistant GAS in vitro and in vivo. Treatment with CLI reduced extracellular DNase Sda1 and streptolysin O (SLO) activity in vivo, whereas subinhibitory CLI concentrations induced expression and activity of SLO, DNase, and Streptococcus pyogenes cell envelope protease in vitro. Our in vivo results suggest that CLI should be administered as soon as possible to patients with necrotizing fasciitis, while our in vitro studies emphasize that a high dosage of CLI is essential.
Aggregate Corporate Liquidity and Stock Returns

Aggregate investment in cash and liquid assets as a share of total corporate investment is negatively related to subsequent U.S. stock market returns between 1947 and 2003. The share of cash in total investment is a more stable predictor of returns than scaled price variables and performs well in out-of-sample predictability tests. Cash investment is a stronger predictor of market returns in years in which external financing is also high. The results support a theory in which firms in the aggregate actively time security issuance relative to investment needs, taking advantage of a time varying cost of capital.
Infrastructure and human development: the case of Java, Indonesia

This study examines the relationship between infrastructure and human development in Java, Indonesia, using regency-level 2002–2005 panel data. We find that improving infrastructure significantly enhances human development. In particular, electricity infrastructure has a greater influence on human development than other types of infrastructure, such as clean water, roads or the number of classrooms per student. We find that for every 1% increase in the proportion of households with electricity, the human development index (HDI) increases by 0.2%. Improvements in other types of infrastructure lead over the long run to lesser increases in the HDI, ranging from 0.01% to 0.03%.
Maltrato entre iguales y exclusión social en la comunidad de Madrid : análisis y posibilidades de intervención

The purpose of this research was to study school violence and exclusion across different educational levels in the Madrid Region, Spain. Participants were 1,635 students (aged 14-18 years) with different education levels –compulsory secondary education, specific/ initial training courses and vocational training. Students filled out a questionnaire that included measures of school satisfaction, type of violence (e.g., exclusion, verbal violence, physical violence, vandalism), violence roles (i.e., aggressors, victims and spectators), and attitudes towards violence (e.g., intolerance, sexism and violence justification). Results indicated that a) social exclusion and verbal violence are the most prevalent types of violence, b) school violence decreased when the educational level increased, and c) special vulnerability was higher among specific groups. Implications and interventions are discussed.
Exploring Employee Outcomes of Organizational Restructuring

Previous research on the effects of organizational restructuring has primarily been conducted using self-report cross-sectional data. These forms of data are vulnerable to several threats to both internal and external validity. Using a Solomon four-group design, this study examined the effects of an organizational restructuring while simultaneously testing for the effects of pretesting, history, and interactions between pretesting and the organizational restructuring. Results suggest the organizational restructuring had consistent negative effects on employee levels of job security, organizational commitment, perceptions of time pressure, psychological well-being, and turnover intentions. Effects on job satisfaction, physical health, and perceptions of role ambiguity were less consistently noted. Theoretical and practical implications of the results are discussed and directions for future research are proposed.
Comprendre les masculinités rurales : un portrait basé sur la santé psychologique

Les hommes ruraux forment une clientele particulierement vulnerable en matiere de suicide et de detresse psychologique et ils utilisent peu les services de sante. Comme toute inegalite sociale de sante, cette situation se heurte a plusieurs valeurs cheres au service social. Malgre son portrait preoccupant, la sante psychologique des hommes ruraux demeure un sujet largement neglige au Quebec, comme dans la plupart des pays industrialises, ce qui contribue a son invisibilite. Cet article vise a mieux comprendre les realites objectives et subjectives des hommes ruraux qui influencent leur sante psychologique. Un volet de l’analyse aborde les principaux paradigmes comprehensifs des hommes et des masculinites qui se sont interessees aux masculinites rurales, ce qui ouvre sur des pistes de recherche.
Treebank-Based Probabilistic Phrase Structure Parsing

The area of probabilistic phrase structure parsing has been a central and active field in computational linguistics. Stochastic methods in natural language processing, in general, have become very popular as more and more resources become available. One of the main advantages of probabilistic parsing is in disambiguation: it is useful for a parsing system to return a ranked list of potential syntactic analyses for a string. In this article, we introduce probabilistic context-free grammars (PCFGs) and outline some of their strengths and weaknesses. We concentrate on the automatic extraction of stochastic grammars from treebanks (large collections of hand-corrected syntactic structures). We describe the current state of the field and the current research on improving the basic PCFG model. This includes lexicalized, history-based and generative models. Finally, we briefly mention some research into probabilistic phrase structure parsing for domains other than traditional treebank text and languages other than English (Chinese, Arabic, German and French).
EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer.

PURPOSE To determine whether adding cetuximab to irinotecan prolongs survival in patients with metastatic colorectal cancer (mCRC) previously treated with fluoropyrimidine and oxaliplatin. PATIENTS AND METHODS This multicenter, open-label, phase III study randomly assigned 1,298 patients with epidermal growth factor receptor-expressing mCRC who had experienced first-line fluoropyrimidine and oxaliplatin treatment failure to cetuximab (400 mg/m(2) day 1 followed by 250 mg/m(2) weekly) plus irinotecan (350 mg/m(2) every 3 weeks) or irinotecan alone. Primary end point was overall survival (OS); secondary end points included progression-free survival (PFS), response rate (RR), and quality of life (QOL). RESULTS Median OS was comparable between treatments: 10.7 months (95% CI, 9.6 to 11.3) with cetuximab/irinotecan and 10.0 months (95% CI, 9.1 to 11.3) with irinotecan alone (hazard ratio [HR], 0.975; 95% CI, 0.854 to 1.114; P = .71). This lack of difference may have been due to post-trial therapy: 46.9% of patients assigned to irinotecan eventually received cetuximab (87.2% of those who did, received it with irinotecan). Cetuximab added to irinotecan significantly improved PFS (median, 4.0 v 2.6 months; HR, 0.692; 95% CI, 0.617 to 0.776; P <or= .0001) and RR (16.4% v 4.2%; P < .0001), and resulted in significantly better scores in the QOL analysis of global health status (P = .047). Cetuximab did not exacerbate toxicity, except for acneform rash, diarrhea, hypomagnesemia, and associated electrolyte imbalances. Neutropenia was the most common severe toxicity across treatment arms. CONCLUSION Cetuximab and irinotecan improved PFS and RR, and resulted in better QOL versus irinotecan alone. OS was similar between study groups, possibly influenced by the large number of patients in the irinotecan arm who received cetuximab and irinotecan poststudy.
Functional Traits Reveal Processes Driving Natural Afforestation at Large Spatial Scales

An understanding of the processes governing natural afforestation over large spatial scales is vital for enhancing forest carbon sequestration. Models of tree species occurrence probability in non-forest vegetation could potentially identify the primary variables determining natural afforestation. However, inferring processes governing afforestation using tree species occurrence is potentially problematic, since it is impossible to know whether observed occurrences are due to recruitment or persistence of existing trees following disturbance. Plant functional traits have the potential to reveal the processes by which key environmental and land cover variables influence afforestation. We used 10,061 survey plots to identify the primary environmental and land cover variables influencing tree occurrence probability in non-forest vegetation in New Zealand. We also examined how these variables influenced diversity of functional traits linked to plant ecological strategy and dispersal ability. Mean annual temperature was the most important environmental predictor of tree occurrence. Local woody cover and distance to forest were the most important land cover variables. Relationships between these variables and ecological strategy traits revealed a trade-off between ability to compete for light and colonize sites that were marginal for tree occurrence. Biotically dispersed species occurred less frequently with declining temperature and local woody cover, suggesting that abiotic stress limited their establishment and that biotic dispersal did not increase ability to colonize non-woody vegetation. Functional diversity for ecological strategy traits declined with declining temperature and woody cover and increasing distance to forest. Functional diversity for dispersal traits showed the opposite trend. This suggests that low temperatures and woody cover and high distance to forest may limit tree species establishment through filtering on ecological strategy traits, but not on dispersal traits. This study shows that ‘snapshot’ survey plot data, combined with functional trait data, may reveal the processes driving tree species establishment in non-forest vegetation over large spatial scales.
The Role of Coupled Sea Surface Temperatures in the Simulation of the Tropical Intraseasonal Oscillation

Abstract This study compares the tropical intraseasonal oscillation (TISO) variability in the Geophysical Fluid Dynamics Laboratory (GFDL) coupled general circulation model (CGCM) and the stand-alone atmospheric general circulation model (AGCM). For the AGCM simulation, the sea surface temperatures (SSTs) were specified using those from the CGCM simulation. This was done so that any differences in the TISO that emerged from the two simulations could be attributed to the coupling process and not to a difference in the mean background state. The comparison focused on analysis of the rainfall, 200-mb velocity potential, and 850-mb zonal wind data from the two simulations, for both summer and winter periods, and included comparisons to analogous diagnostics using NCEP–NCAR reanalysis and Climate Prediction Center (CPC) Merged Analysis of Precipitation (CMAP) rainfall data. The results of the analysis showed three principal differences in the TISO variability between the coupled and uncoupled simulations. The .
Disgust Sensitivity and Attitudes toward Organ Donation among African-American College Students

241 African-American college students (94 men and 147 women, mean age = 20.3 ± 3.4 yr.) completed the 1994 Disgust Scale of Haidt, McCauley, and Rozin and a modified form of Parisi-Rizzo's 1987 Attitudes Toward Organ Donation Scale (negative subscale only) as well as a behavioral measure of intention to donate organs after death. Analyses indicated that the higher the disgust sensitivity, the more negative the attitude toward organ donation and the less likely the student was to indicate intent to donate organs. It was further shown that negative attitudes toward organ donation mediated the relationship between disgust sensitivity and the behavioral intention measure. Results highlight the complexity of the issues surrounding organ donation within an African-American population and provide additional empirical evidence for the development of a theoretical model to explain the organ donation phenomenon.
Stimulation of Human Neutrophils by Chemotactic Factors Is Associated with the Activation of Phosphatidylinositol 3-Kinase γ*

The activation of human polymorphonuclear neutrophil leukocytes (neutrophils) is associated with an increased synthesis of the highly phosphorylated phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). The aims of the present investigation were to determine whether the newly described, G protein-dependent phosphatidylinositol 3-kinase (PI3K), p110γ, was involved in the responses to chemotactic factors interacting with G protein-coupled receptors. The presence of p110γ in neutrophils was first established both at the protein and the mRNA level. Stimulation of the cells with fMet-Leu-Phe or interleukin-8 increased the PI3K activity in p110γ, but not p85, immunoprecipitates. The time course of this effect (threshold within less than 5 s, maximal activation at 10–15 s) was consistent with that of the generation of PtdIns(3,4,5)P3. Wortmannin, a PI3K inhibitor, abrogated the effects of fMet-Leu-Phe, which were also significantly inhibited by pertussis toxin. Finally, fMet-Leu-Phe also induced a significant translocation of p110γ to a particulate fraction derived from these cells. These data indicate that p110γ represent the major PI3K activated by fMet-Leu-Phe and interleukin-8 at very early time points following the stimulation of human neutrophils.