Miracle-dz/UniFAR-FTUs huggingface dataset:
Block based Spectral Processing of Dense 3D Meshes using Orthogonal Iterations

Spectral methods are widely used in geometry processing of 3D models. They rely on the projection of the mesh geometry on the basis defined by the eigenvectors of the graph Laplacian operator, becoming computationally prohibitive as the density of the models increases. In this paper, we propose a novel approach for supporting fast and efficient spectral processing of dense 3D meshes, ideally suited for real time compression and denoising scenarios. To achieve that, we apply the problem of tracking graph Laplacian eigenspaces via orthogonal iterations, exploiting potential spectral coherences between adjacent parts. To avoid perceptual distortions when a fixed number of eigenvectors is used for all the individual parts, we propose a flexible solution that automatically identifies the optimal subspace size for satisfying a given reconstruction quality constraint. Extensive simulations carried out with different 3D meshes in compression and denoising setups, showed that the proposed schemes are very fast alternatives of SVD based spectral processing while achieving at the same time similar or even better reconstruction quality. More importantly, the proposed approach can be employed by several other state of the art denoising methods as a preprocessing step, optimizing both their reconstruction quality and their computational complexity.
Variables that Predict Serve Efficacy in Elite Men’s Volleyball with Different Quality of Opposition Sets

Abstract The objective of this study was to determine the variables that predicted serve efficacy in elite men’s volleyball, in sets with different quality of opposition. 3292 serve actions were analysed, of which 2254 were carried out in high quality of opposition sets and 1038 actions were in low quality of opposition sets, corresponding to a total of 24 matches played during the Men’s European Volleyball Championships held in 2011. The independent variables considered in this study were the serve zone, serve type, serving player, serve direction, reception zone, receiving player and reception type; the dependent variable was serve efficacy and the situational variable was quality of opposition sets. The variables that acted as predictors in both high and low quality of opposition sets were the serving player, reception zone and reception type. The serve type variable only acted as a predictor in high quality of opposition sets, while the serve zone variable only acted as a predictor in low quality of opposition sets. These results may provide important guidance in men’s volleyball training processes.
Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity

ABSTRACT Malaria remains a global health burden partly due to Plasmodium parasite resistance to first-line therapeutics. The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an essential protein for blood-stage Plasmodium parasites, but details about its function during malaria's elusive liver stage are unclear. We used target-based screens to identify compounds that bind to Plasmodium falciparum and human Hsp90, which revealed insights into chemotypes with species-selective binding. Using cell-based malaria assays, we demonstrate that all identified Hsp90-binding compounds are liver- and blood-stage Plasmodium inhibitors. Additionally, the Hsp90 inhibitor SNX-0723 in combination with the phosphatidylinositol 3-kinase inhibitor PIK-75 synergistically reduces the liver-stage parasite load. Time course inhibition studies with the Hsp90 inhibitors and expression analysis support a role for Plasmodium Hsp90 in late-liver-stage parasite development. Our results suggest that Plasmodium Hsp90 is essential to liver- and blood-stage parasite infections and highlight an attractive route for development of species-selective PfHsp90 inhibitors that may act synergistically in combination therapies to prevent and treat malaria.
Handling Homographs in Neural Machine Translation

Homographs, words with different meanings but the same surface form, have long caused difficulty for machine translation systems, as it is difficult to select the correct translation based on the context. However, with the advent of neural machine translation (NMT) systems, which can theoretically take into account global sentential context, one may hypothesize that this problem has been alleviated. In this paper, we first provide empirical evidence that existing NMT systems in fact still have significant problems in properly translating ambiguous words. We then proceed to describe methods, inspired by the word sense disambiguation literature, that model the context of the input word with context-aware word embeddings that help to differentiate the word sense before feeding it into the encoder. Experiments on three language pairs demonstrate that such models improve the performance of NMT systems both in terms of BLEU score and in the accuracy of translating homographs.
Rapid and dynamic arginylation of the leading edge β‐actin is required for cell migration

β‐actin plays key roles in cell migration. Our previous work demonstrated that β‐actin in migratory non‐muscle cells is N‐terminally arginylated and that this arginylation is required for normal lamellipodia extension. Here, we examined the function of β‐actin arginylation in cell migration. We found that arginylated β‐actin is concentrated at the leading edge of lamellipodia and that this enrichment is abolished after serum starvation as well as in contact‐inhibited cells in confluent cultures, suggesting that arginylated β‐actin at the cell leading edge is coupled to active migration. Arginylated actin levels exhibit dynamic changes in response to cell stimuli, lowered after serum starvation and dramatically elevating within minutes after cell stimulation by readdition of serum or lysophosphatidic acid. These dynamic changes require active translation and are not seen in confluent contact‐inhibited cell cultures. Microinjection of arginylated actin antibodies into cells severely and specifically inhibits their migration rates. Together, these data strongly suggest that arginylation of β‐actin is a tightly regulated dynamic process that occurs at the leading edge of locomoting cells in response to stimuli and is integral to the signaling network that regulates cell migration.
Delineating Potential Transcriptomic Association with Organochlorine Pesticides in the Etiology of Epithelial Ovarian Cancer

Background: Recent studies have shown that there is an increased risk of Epithelial Ovarian Cancer (EOC) with Organochlorine Pesticides (OCPs). However, the alteration in the gene expression profile has not been explored so far. The goal of the present study is to understand the probable molecular mechanism of OCPs toxicity towards discovery of dysregulation of signaling pathway associated with differential gene expression and candidate transcriptomic set of markers in the pathophysiology of EOC in OCPs exposed population. Methods: The OCP levels were estimated by gas chromatography and whole genome differential expression study was carried out using expression microarray and candidate genes were validated using Real time RT-PCR. Results: Significant level of OCP residues such as β-hexachlorocyclohexane (β-HCH), Heptachlor, Heptachlor epoxide B (HTEB), dichlorodiphenyldichloroethylene (p’p’-DDE) and endosulfan-I was found between healthy and EOC patients. The transcriptome profile of several genes revealed regulation of various important cellular processes such as metabolism, inflammation, cytoskeleton dysregulation of TGF and WNT pathway in EOC cases with high OCPs. Conclusion: This study provides the first evidence showing that differentially expressed genes and dysregulation of signaling pathways might be associated with significant level of OCPs exposure in ovary tissue of epithelial ovarian cancer patients. Moreover, significant correlation of these genes with OCPs revealed that OCPs exposure played vital role in dysregulation of related pathways in the etiology of EOC
Effects of nanostructured, diamondlike, carbon coating and nitrocarburizing on the frictional properties and biocompatibility of orthodontic stainless steel wires.

OBJECTIVE To evaluate and compare the effects of nanostructured, diamondlike, carbon (DLC) coating and nitrocarburizing on the frictional properties and biocompatibility of orthodontic stainless steel archwires. MATERIALS AND METHODS Plasma-enhanced chemical vapor deposition technology was applied to coat DLC films onto the surface of austenitic stainless steel wires, and salt-bath nitrocarburizing technology was employed to achieve surface hardening of other wires. Surface and cross-sectional characteristics, microhardness, modulus of elasticity, friction resistance, corrosion resistance, and cell toxicity of the modified and control wires were analyzed. RESULTS The surfaces of the DLC-coated and nitrocarburized wires were both smooth and even. Compared with the control, the DLC-coated wires were increased in surface hardness 1.46 times, decreased in elastic modulus, reduced in kinetic friction coefficient by 40.71%, and decreased in corrosion current density by two orders of magnitude. The nitrocarburized wire was increased in surface hardness 2.39 times, exhibited an unchanged elastic modulus, demonstrated a decrease in maximum static friction force of 22.2%, and rose in corrosion current density two orders of magnitude. Cytotoxicity tests revealed no significant toxicity associated with the modified wires. CONCLUSIONS DLC coating and nitrocarburizing significantly improved the surface hardness of the wires, reduced friction, and exhibited good biocompatibility. The nanostructured DLC coating provided excellent corrosion resistance and good elasticity, and while the nitrocarburizing technique substantially improved frictional properties, it reduced the corrosion resistance of the stainless steel wires to a lesser extent.
Impaired G protein function in gallbladder muscle from progesterone-treated guinea pigs.

This study was designed to elucidate the mechanism of action of progesterone on gallbladder smooth muscle in guinea pigs. Adult male guinea pigs were treated with either progesterone (2 mg ⋅ kg-1 ⋅ day-1) or saline for 7 days. Gallbladder muscle cells were isolated by enzymatic digestion with collagenase. Contractile responses to agonists were expressed as percent shortening from control cell length. [35S]guanosine 5'- O-(3-thiotriphosphate) ([35S]GTPγS)-binding properties of G proteins were assessed in crude membranes of gallbladder muscle with or without cholecystokinin octapeptide (CCK-8) stimulation. Gallbladder muscle cells from progesterone-treated guinea pigs exhibited an impaired contractile response to CCK-8, GTPγS, or aluminum fluoride but a normal response to potassium chloride ord- myo-inositol 1,4,5-trisphosphate compared with controls. Western blot analysis of gallbladder muscle revealed the presence of Gi 1-2, Gi 3, Gq/11, and Gs proteins. The maximal contraction induced by CCK-8 was blocked by pertussis toxin and Giα3-specific antibodies, but not by Giα1-2or Gq/11α antibodies. CCK-8 caused a significant increase in [35S]GTPγS binding to Giα3, but not to Gq/11α or Giα1-2. The stimulation of Giα3binding, however, was significantly reduced in gallbladder muscle membranes from progesterone-treated guinea pigs compared with that in control animals. In conclusion, progesterone might cause gallbladder hypomotility by downregulating Gi 3 proteins.
Atomic Force Microscopy Provides New Mechanistic Insights into the Pathogenesis of Pemphigus

Autoantibodies binding to the extracellular domains of desmoglein (Dsg) 3 and 1 are critical in the pathogenesis of pemphigus by mechanisms leading to impaired function of desmosomes and blister formation in the epidermis and mucous membranes. Desmosomes are highly organized protein complexes which provide strong intercellular adhesion. Desmosomal cadherins such as Dsgs, proteins of the cadherin superfamily which interact via their extracellular domains in Ca2+-dependent manner, are the transmembrane adhesion molecules clustered within desmosomes. Investigations on pemphigus cover a wide range of experimental approaches including biophysical methods. Especially atomic force microscopy (AFM) has recently been applied increasingly because it allows the analysis of native materials such as cultured cells and tissues under near-physiological conditions. AFM provides information about the mechanical properties of the sample together with detailed interaction analyses of adhesion molecules. With AFM, it was recently demonstrated that autoantibodies directly inhibit Dsg interactions on the surface of living keratinocytes, a phenomenon which has long been considered the main mechanism causing loss of cell cohesion in pemphigus. In addition, AFM allows to study how signaling pathways altered in pemphigus control binding properties of Dsgs. More general, AFM and other biophysical studies recently revealed the importance of keratin filaments for regulation of Dsg binding and keratinocyte mechanical properties. In this mini-review, we reevaluate AFM studies in pemphigus and keratinocyte research, recapitulate what is known about the interaction mechanisms of desmosomal cadherins and discuss the advantages and limitations of AFM in these regards.
Comparison of three-point belt fit between humans and ATDs in rear seats

ABSTRACT Objective: The anthropomorphic test devices (ATDs) in the Hybrid III family are widely used as human surrogates to test the crash performance of vehicles. A previous study demonstrated that passenger belt fit in rear seats was affected by high body mass index (BMI) and to a lesser extent by increased age. Specifically, the lap belt was worn higher and more forward as BMI and age increased. The objective of this study was to compare passenger belt fit to the belt fit achieved when installing the small female and midsize male Hybrid III adult ATDs using standard procedures. Methods: The ATDs were installed using standardized procedures in the same conditions previously used with volunteers. Belt fit was measured using methods analogous to those used for the volunteers. Comparative human belt fit values were obtained by using regression analysis with the volunteer data to calculate the mean expected belt fit for people the same size as the ATDs. Results: For the small female ATD, the upper edge of the lap belt was on average 59 mm forward and 11 mm above the anterior–superior iliac spine (ASIS) landmark on the ATD pelvis bone. In contrast, the belt position for similar size passengers was 17 mm forward and 22 mm above the ASIS. For the midsize male ATD, the belt was 34 mm forward and 10 mm above the ASIS. For similar size passengers, the position was 38 mm forward and 44 mm above the ASIS. For context, the belt width in this study was 38 mm. Discussion: The results suggest that the lap belt fit obtained by ATDs is more idealized but more repeatable compared to that achieved by similar size passengers. Future standardization efforts should consider investigating whether new belt-positioning procedures with ATDs may improve the biofidelity of ATD response.
Problems With Reliability of Speech Variables for Use in Quality Registries for Cleft Lip and Palate—Experiences From the Swedish Cleft Lip and Palate Registry

Objective: To test the reliability of the speech data in the Swedish quality registry for cleft lip and palate. Design: Retrospective study. Setting: Primary care university hospital. Participants: Ninety-four children born with cleft palate with or without cleft lip between 2005 and 2009 who had been assessed and registered in the quality registry at the age of 5 years. Main Outcome Measures: Data in the registry on percent oral consonants correct, percent oral errors, percent nonoral errors, perceived velopharyngeal function (PVPF), and intelligibility were compared with results based on reassessments by 3 independent raters from audio recordings. Agreement was calculated by the intraclass correlation coefficient (ICC), quadratic weighted kappa, and percentage agreement. Results: Absolute agreement calculated by average measures ICC for percent oral consonants correct, percent oral errors, and percent nonoral errors was above >0.90. Single measures ICC for percent oral consonants correct was 0.82, for percent oral errors 0.69, and for percent nonoral errors 0.83. The kappa coefficient for PVPF was 0.5 to 0.59 and for intelligibility 0.65 to 0.77. Exact percentage agreement for PVPF was 33% and for intelligibility 47.8%. Conclusions: The data on oral consonants correct and nonoral errors in the quality registry seem to be reliable. The data on oral errors, PVPF, and intelligibility should be interpreted with caution. If differences among treatment centers are detected, one should go back and examine the collected raw data before drawing any definitive conclusions about treatment outcome.
Cyclical Population Dynamics of Automatic Versus Controlled Processing: An Evolutionary Pendulum

Psychologists, neuroscientists, and economists often conceptualize decisions as arising from processes that lie along a continuum from automatic (i.e., “hardwired” or overlearned, but relatively inflexible) to controlled (less efficient and effortful, but more flexible). Control is central to human cognition, and plays a key role in our ability to modify the world to suit our needs. Given its advantages, reliance on controlled processing may seem predestined to increase within the population over time. Here, we examine whether this is so by introducing an evolutionary game theoretic model of agents that vary in their use of automatic versus controlled processes, and in which cognitive processing modifies the environment in which the agents interact. We find that, under a wide range of parameters and model assumptions, cycles emerge in which the prevalence of each type of processing in the population oscillates between 2 extremes. Rather than inexorably increasing, the emergence of control often creates conditions that lead to its own demise by allowing automaticity to also flourish, thereby undermining the progress made by the initial emergence of controlled processing. We speculate that this observation may have relevance for understanding similar cycles across human history, and may lend insight into some of the circumstances and challenges currently faced by our species.
Wing Loss for Robust Facial Landmark Localisation with Convolutional Neural Networks

We present a new loss function, namely Wing loss, for robust facial landmark localisation with Convolutional Neural Networks (CNNs). We first compare and analyse different loss functions including L2, L1 and smooth L1. The analysis of these loss functions suggests that, for the training of a CNN-based localisation model, more attention should be paid to small and medium range errors. To this end, we design a piece-wise loss function. The new loss amplifies the impact of errors from the interval (-w, w) by switching from L1 loss to a modified logarithm function. To address the problem of under-representation of samples with large out-of-plane head rotations in the training set, we propose a simple but effective boosting strategy, referred to as pose-based data balancing. In particular, we deal with the data imbalance problem by duplicating the minority training samples and perturbing them by injecting random image rotation, bounding box translation and other data augmentation approaches. Last, the proposed approach is extended to create a two-stage framework for robust facial landmark localisation. The experimental results obtained on AFLW and 300W demonstrate the merits of the Wing loss function, and prove the superiority of the proposed method over the state-of-the-art approaches.
E-p-Methoxycinnamoyl-α-l-rhamnopyranosyl Ester, a Phenylpropanoid Isolated from Scrophularia buergeriana, Increases Nuclear Factor Erythroid-Derived 2-Related Factor 2 Stability by Inhibiting Ubiquitination in Human Keratinocytes

The nuclear factor erythroid-derived 2-related factor 2 (Nrf2) is a key regulator of gene expression during oxidative stress and drug detoxification. Thus, identifying Nrf2 activators to protect from possible cell damage is necessary. In this study, we investigated whether E-p-methoxycinnamoyl-α-l-rhamnopyranosyl ester (MCR), a phenylpropanoid isolated from Scrophularia buergeriana, can activate Nrf2 signaling in human keratinocytes (HaCaT). First, we determined the dose- and time-dependent effects of MCR on the expression and activity of Nrf2. The antioxidant response element-luciferase reporter assay and western blot analysis results showed that MCR markedly induced Nrf2 activity and its protein expression, respectively. Further, MCR increased both the mRNA and protein levels of heme-oxygenase-1, one of the Nrf2 target genes, in the cells. Interestingly, we found that Nrf2 stability was remarkably enhanced by MCR. Furthermore, ubiquitin-dependent proteasomal degradation of Nrf2 was significantly reduced by MCR. Thus, MCR might afford skin protection by enhancing Nrf2 stability or by blocking its proteasomal degradation.
L-type Ca2+ current and excitation-contraction coupling in single atrial myocytes from rainbow trout.

We have examined the contribution of L-type Ca2+ current ( I Ca) to the activation of contraction in trout atrial myocytes under basal and phosphorylating conditions. The average myocyte length was 197 ± 14 μm, width was 5.5 ± 0.2 μm, and cell capacitance was 36.2 ± 2.2 pF. With 25 μM EGTA in the patch pipette and a stimulation frequency of 0.125 Hz, I Cawas 2.6 ± 0.4 pA/pF and it carried a total charge of 0.10 ± 0.01 pC/pF, giving rise to a contraction of 15.2 ± 2.8% of the resting cell length. With a cell volume of 2.4 ± 0.3 pl, the charge carried by I Cacorresponded to 14.7 ± 2.2 μmol Ca2+/l nonmitochondrial cell volume (μM). This can account for only 30-40% of the Ca2+ binding to the myofilaments during a contraction. Increasing the stimulation frequency from 0.25 to 2 Hz decreased I Caamplitude and charge by 66 ± 5 and 80 ± 3%, respectively. Elevating the pipette EGTA concentration from 25 μM to 5 mM increased I Caamplitude and charge by ∼290%. Both isoproterenol and cAMP increased I Caby ∼230%. The total charge carried by the isoproterenol- or cAMP-stimulated current was increased by 170%. We conclude that the use of high-EGTA concentration may overestimate the total Ca2+ carried by I Caunder physiological conditions. Furthermore, the results suggest that, in contrast to previous reports from other lower vertebrates, Ca2+ flux through L-type Ca2+ channels alone is not sufficient to fully activate contraction in trout atrial myocytes at room temperature.