Miracle-dz/UniFAR-FTUs huggingface dataset:
Random sampling LDA incorporating feature selection for face recognition

Classical Linear Discriminant Analysis(LDA) is usually suffers from the small sample size(SSS) problem when dealing with the high dimensional face data. Many methods have been proposed for solving this problem such as Fisherface and Null Space LDA(N-LDA), but these methods are overfitted to the training set and inevitably lose some useful discriminative information in many cases. To effectively utilize nearly all useful discriminative information, a not completely random sampling framework for the integration of multiple features is developed. However, this method has the following main disadvantage: By directly employing feature extraction, the newly constructed variables may contain lots of information originated from those redundant features in the original space. So, in this paper, we introduce a new random sampling LDA by incorporating feature selection for face recognition, that is, some redundant features are removed using the given feature selection methods at first, and then PCA is employed, finally we use random sampling to generate multiple feature subsets. Along this, corresponding weak LDA classifiers are naturally generated and an integrated classifier is developed using a fusion rule. Experiments on 4 face datasets(AR, ORL, Yale, YaleB) show the effectiveness of our algorithm.
Nodal patterning without Lefty inhibitory feedback is functional but fragile

Developmental signaling pathways often activate their own inhibitors. Such inhibitory feedback has been suggested to restrict the spatial and temporal extent of signaling or mitigate signaling fluctuations, but these models are difficult to rigorously test. Here, we determine whether the ability of the mesendoderm inducer Nodal to activate its inhibitor Lefty is required for development. We find that zebrafish lefty mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality. Strikingly, development can be fully restored without feedback: Lethal patterning defects in lefty mutants can be rescued by ectopic expression of lefty far from its normal expression domain or by spatially and temporally uniform exposure to a Nodal inhibitor drug. While drug-treated mutants are less tolerant of mild perturbations to Nodal signaling levels than wild type embryos, they can develop into healthy adults. These results indicate that patterning without inhibitory feedback is functional but fragile.
Maternal prolactin inhibition during lactation programs for metabolic syndrome in adult progeny

Neonatal malnutrition is associated with metabolic syndrome in adulthood. Maternal hypoprolactinaemia at the end of lactation (a precocious weaning model) caused obesity, leptin resistance and hypothyroidism in adult offspring, suggesting an association of prolactin (PRL) and programming of metabolic dysfunctions. Metabolic syndrome pathogenesis is still unclear, but abdominal obesity, higher triglycerides, lower high‐density lipoprotein (HDL‐c) and insulin resistance have been proposed to be important factors involved. We studied the consequences of maternal hypoprolactinaemia during lactation on parameters associated with metabolic syndrome. Lactating Wistar rats were treated with bromocriptine (BRO, 1 mg twice a day) or saline on days 19, 20 and 21 of lactation and their offspring were followed from weaning until 180 days old. Adult BRO offspring had higher body weight (+10%, P < 0.05), total body fat (+41%, P < 0.05), visceral fat (+20%, P < 0.05), subcutaneous fat (+3 times, P < 0.05) and total body protein (+24%, P < 0.05). BRO group presented hyperglycaemia (+16%, P < 0.05), lower muscle glycogen (−51%, P < 0.05), higher cholesterol (+30%, P < 0.05), higher low‐density lipoprotein (LDL‐c) (+1.5 times, P < 0.05), higher triglycerides (+49%, P < 0.05), lower HDL‐c (−28%, P < 0.05), hyperleptinaemia (+2.9 times, P < 0.05), hypoadiponectinaemia (−16%, P < 0.05) and hypoprolactinaemia (−54%, P < 0.05) as well as higher insulin resistance index (+24%, P < 0.05). Regarding adrenal function, BRO rats showed hypercorticosteronaemia (+46%, P < 0.05) and higher total catecholamine (+37%, P < 0.05). In the hypothalamus, no change was observed in protein expression of the leptin signalling pathway. Thus, neonatal malnutrition induced by maternal PRL inhibition during late lactation programs for obesity, dyslipidaemia and insulin resistance in adult offspring increasing the risk for metabolic syndrome development.
Efficient Rekeying Framework for Secure Multicast with Diverse-Subscription-Period Mobile Users

Group key management (GKM) in mobile communication is important to enable access control for a group of users. A major issue in GKM is how to minimize the communication cost for group rekeying. To design the optimal GKM, researchers have assumed that all group members have the same leaving probabilities and that the tree is balanced and complete to simplify analysis. In the real mobile computing environment, however, these assumptions are impractical and may lead to a large gap between the impractical analysis and the measurement in real-life situations, thus allowing for GKM schemes to incorporate only a specific number of users. In this paper, we propose a new GKM framework supporting more general cases that do not require these assumptions. Our framework consists of two algorithms: one for initial construction of a basic key-tree and another for optimizing the key-tree after membership changes. The first algorithm enables the framework to generate an optimal key-tree that reflects the characteristics of users' leaving probabilities, and the second algorithm allows continual maintenance of communication with less overhead in group rekeying. Through simulations, we show that our GKM framework outperforms the previous one which is known to be the best balanced and complete structure.
The Influence of the U.S. News and World Report Collegiate Rankings on the Matriculation Decision of High-Ability Students: 1995-2003

The annual U.S. News and World Report (USNWR) Guide to America’s Best Colleges is a much anticipated magazine among both high-ability prospective students and college and university administrators. In this paper we use a decade of Colgate University Admitted Student Questionnaire surveys to estimate the influence of changes in a school’s USNWR rank on the probability of matriculation of high-ability students. We find that the school choice of students is more responsive to changes in rank the higher (better) a school is ranked. This sensitivity to rank is independent of other objective measures of quality. As a group, women (aided and fullpay) are slightly less sensitive to the rankings than men, minorities (full-pay) are less sensitive to the rankings than non-minorities, and the rankings themselves have become more important over time for aided students. In terms of financial factors, the net cost of attendance along with the packaging of the aid matters for aided students. Finally, merit aid in general does not appear to influence high-ability full-pay students. Our results suggest that it is rational for college administrators (especially those at the highest ranked institutions) to pay attention to their USNWR rank because it is an important influence in yielding accepted students.
Job Detection in Twitter

In this report, we propose a new application for twitter data called \textit{job detection}. We identify people's job category based on their tweets. As a preliminary work, we limited our task to identify only IT workers from other job holders. We have used and compared both simple bag of words model and a document representation based on Skip-gram model. Our results show that the model based on Skip-gram, achieves a 76\% precision and 82\% recall.
A critical review of the development of face recognition: Experience is less important than previously believed

Historically, it has been argued that face individuation develops very slowly, not reaching adult levels until adolescence, with experience being the driving force behind this protracted improvement. Here, we challenge this view based on extensive review of behavioural and neural findings. Results demonstrate qualitative presence of all key phenomena related to face individuation (encoding of novel faces, holistic processing effects, face-space effects, face-selective responses in neuroimaging) at the earliest ages tested, typically 3–5 years of age and in many cases even infancy. Results further argue for quantitative maturity by early childhood, based on an increasing number of behavioural studies that have avoided the common methodological problem of restriction of range, as well as event-related potential (ERP), but not functional magnetic resonance imaging (fMRI) studies. We raise a new possibility that could account for the discrepant fMRI findings—namely, the use of adult-sized head coils on child-sized heads. We review genetic and innate contributions to face individuation (twin studies, neonates, visually deprived monkeys, critical periods, perceptual narrowing). We conclude that the role of experience in the development of the mechanisms of face identification has been overestimated. The emerging picture is that the mechanisms supporting face individuation are mature early, consistent with the social needs of children for reliable person identification in everyday life, and are also driven to an important extent by our evolutionary history.
Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo.

BACKGROUND Long-chain n-3 PUFAs found in oily fish may have a role in lowering the risk of allergic disease. OBJECTIVE The objective was to assess whether an increased intake of oily fish in pregnancy modifies neonatal immune responses and early markers of atopy. DESIGN Women (n = 123) were randomly assigned to continue their habitual diet, which was low in oily fish, or to consume 2 portions of salmon per week (providing 3.45 g EPA plus DHA) from 20 wk gestation until delivery. In umbilical cord blood samples (n = 101), we measured n-3 fatty acids, IgE concentrations, and immunologic responses. Infants were clinically evaluated at age 6 mo (n = 86). RESULTS Cord blood mononuclear cell (CBMC) production of interleukin (IL)-2, IL-4, IL-5, IL-10, and tumor necrosis factor-α in response to phytohemagglutinin (PHA) and of IL-2 in response to Dermatophagoides pteronyssinus allergen 1 (Derp1) was lower in the salmon group (all P ≤ 0.03). In the subgroup of CBMCs in which an allergic phenotype was confirmed in the mother or father, IL-10 production in response to Toll-like receptor 2, 3, and 4 agonists, ovalbumin, salmon parvalbumin, or Derp1 and prostaglandin E(2) production in response to lipopolysaccharide or PHA was lower in the salmon group (all P ≤ 0.045). Total IgE at birth and total IgE, incidence and severity of atopic dermatitis, and skin-prick-test positivity at 6 mo of age were not different between the 2 groups. CONCLUSION Oily fish intervention in pregnancy modifies neonatal immune responses but may not affect markers of infant atopy assessed at 6 mo of age. This trial is registered at clinicaltrials.gov as NCT00801502.
Estrogen Promotes Early Osteoblast Differentiation and Inhibits Adipocyte Differentiation in Mouse Bone Marrow Stromal Cell Lines that Express Estrogen Receptor (ER) α or β.

Although cells of the osteoblast lineage express functional ERs, direct effects of estrogen on bone formation remain obscure. In the present study, we have investigated estrogen effects on osteoblastic and adipocytic differentiation from a mouse bone marrow stromal cell line, ST-2, which had been manipulated to overexpress either human ER (ST2ER )o r ER (ST2ER). Treatment with bone morphogenetic protein-2 increased alkaline phosphatase activity as well as the number of Oil Red O-positive adipocytes, indicating that bone morphogenetic protein-2 stimulated both osteoblastic and adipocytic differentiation from these bipotential cells. In both ST2ER and ST2ER cells, cotreatment with E2 caused enhancement of alkaline phosphatase activity and suppression of lipid accumulation. These effects were completely reversed by an ER antagonist, ICI182780. Therefore, the estrogen regulation occurred in an ER-specific manner but without ER subtype specificity. Moreover, dose response curves of the opposing effects of estrogen on osteoblastogenesis and adipogenesis formed an apparent mirror image, consistent with a reciprocal regulation of differentiation into the two cell lineages. These results demonstrate that estrogen directly modulates differentiation of bipotential stromal cells into the osteoblast and adipocyte lineages, causing a lineage shift toward the osteoblast. Such effects would lead to direct stimulation of bone formation and thereby contribute to the protective effects of estrogen on bone. (Endocrinology 143: 2349 –2356, 2002)
Integrated Modeling of Polymer Composites Under High Energy Laser Irradiation

Abstract : This report is a summary of research activities funded by AFOSR Lab Task 13RXCOR. An integrated computational materials science and engineering (ICMSE) approach was used to investigate the role of fiber-matrix interfaces in controlling optical and thermal energy flow in structural composite materials subject to high energy laser irradiation. Modeling tools, including molecular dynamics and finite elements methods, were used to characterize optical and thermal transport at multiple length scales spanning from nanometers to millimeters. Advanced experimental characterization techniques were used to parameterize and validate these models. Two new experimental techniques were developed at AFRL as part of this project: lateral thermal transport measurements using scanning thermal microscopy (SThM), and microscale temperature sensing via gold nanorods. Modeling and experimental techniques are explained, and important considerations for future work are outlined. Peer-reviewed articles containing detailed results and analysis are included as an appendix.
Delay in cART Initiation Results in Persistent Immune Dysregulation and Poor Recovery of T-Cell Phenotype Despite a Decade of Successful HIV Suppression

Background Successful combination antiretroviral therapy (cART) increases levels of CD4+ T-cells, however this increase may not accurately reflect long-term immune recovery since T-cell dysregulation and loss of T-cell homeostasis often persist. We therefore assessed the impact of a decade of effective cART on immune regulation, T-cell homeostasis, and overall T-cell phenotype. Methods We conducted a retrospective study of 288 HIV+ cART-naïve patients initiating therapy. We identified 86 individuals who received cART for at least a decade, of which 44 consistently maintained undetectable plasma HIV-RNA levels throughout therapy. At baseline, participants were classified into three groups according to pre-treatment CD4+ T-cell counts: Group I (CD4<200 cells/mm3); Group II (CD4: 200–350 cells/mm3); Group III (CD4>350 cells/mm3). Outcomes of interest were: (1) CD4+ T-cell count restoration (CD4>532 cells/mm3); (2) normalization of CD4:CD8 T-cell ratio (1.2–3.3); (3) maintenance of CD3+ T-cell homeostasis (CD3: 65%–85% of peripheral lymphocytes); (4) normalization of the complete T-cell phenotype (TCP). Results Despite a decade of sustained successful cART, complete T-cell phenotype normalization only occurred in 16% of patients, most of whom had initiated therapy at high CD4+ T-cell counts (>350 cells/mm3). The TCP parameter that was the least restored among patients was the CD4:CD8 T-cell ratio. Conclusions Failure to normalize the complete T-cell phenotype was most apparent in patients who initiated cART with a CD4+ T-cell count <200 cells/mm3. The impact of this impaired T-cell phenotype on life-long immune function and potential comorbidities remains to be elucidated.
Virus-mediated suppression of host non-self recognition facilitates horizontal transmission of heterologous viruses

Non-self recognition is a common phenomenon among organisms; it often leads to innate immunity to prevent the invasion of parasites and maintain the genetic polymorphism of organisms. Fungal vegetative incompatibility is a type of non-self recognition which often induces programmed cell death (PCD) and restricts the spread of molecular parasites. It is not clearly known whether virus infection could attenuate non-self recognition among host individuals to facilitate its spread. Here, we report that a hypovirulence-associated mycoreovirus, named Sclerotinia sclerotiorum mycoreovirus 4 (SsMYRV4), could suppress host non-self recognition and facilitate horizontal transmission of heterologous viruses. We found that cell death in intermingled colony regions between SsMYRV4-infected Sclerotinia sclerotiorum strain and other tested vegetatively incompatible strains was markedly reduced and inhibition barrage lines were not clearly observed. Vegetative incompatibility, which involves Heterotrimeric guanine nucleotide-binding proteins (G proteins) signaling pathway, is controlled by specific loci termed het (heterokaryon incompatibility) loci. Reactive oxygen species (ROS) plays a key role in vegetative incompatibility-mediated PCD. The expression of G protein subunit genes, het genes, and ROS-related genes were significantly down-regulated, and cellular production of ROS was suppressed in the presence of SsMYRV4. Furthermore, SsMYRV4-infected strain could easily accept other viruses through hyphal contact and these viruses could be efficiently transmitted from SsMYRV4-infected strain to other vegetatively incompatible individuals. Thus, we concluded that SsMYRV4 is capable of suppressing host non-self recognition and facilitating heterologous viruses transmission among host individuals. These findings may enhance our understanding of virus ecology, and provide a potential strategy to utilize hypovirulence-associated mycoviruses to control fungal diseases.
Improved inapproximability results for counting independent sets in the hard‐core model

We study the computational complexity of approximately counting the number of independent sets of a graph with maximum degree Δ. More generally, for an input graph G=(V,E) and an activity λ>0 , we are interested in the quantity ZG(λ) defined as the sum over independent sets I weighted as w(I)=λ|I| . In statistical physics, ZG(λ) is the partition function for the hard‐core model, which is an idealized model of a gas where the particles have non‐negligible size. Recently, an interesting phase transition was shown to occur for the complexity of approximating the partition function. Weitz showed an FPAS for the partition function for any graph of maximum degree Δ when Δ is constant and λ0 . We remove the upper bound in the assumptions of Sly's result for Δ≠4,5 , that is, we show that there does not exist efficient randomized approximation algorithms for all λ>λc(TΔ) for Δ=3 and Δ≥6 . Sly's inapproximability result uses a clever reduction, combined with a second‐moment analysis of Mossel, Weitz and Wormald which prove torpid mixing of the Glauber dynamics for sampling from the associated Gibbs distribution on almost every regular graph of degree Δ for the same range of λ as in Sly's result. We extend Sly's result by improving upon the technical work of Mossel et al., via a more detailed analysis of independent sets in random regular graphs. © 2012 Wiley Periodicals, Inc. Random Struct. Alg. , 45, 78–110, 2014
Oral contraceptives and risk of breast cancer

A national population‐based case‐control study was conducted in New Zealand to assess the effects of hormonal contraception on breast‐cancer risk. A total of 891 women aged 25 to 54 with a first diagnosis of breast cancer, and 1864 control subjects, randomly selected from the electoral rolls, were interviewed. The relative risk of breast cancer for women who had ever used oral contraceptives was 1.0 (95% confidence interval 0.82‐1.3). There was no increase in risk with duration of use, even among women who had continued to use oral contraceptives for 14 or more years (relative risk = 1.1, 95% confidence interval 0.78‐1.7). The risk of breast cancer was not increased by use of oral contraceptives for long periods before the first pregnancy or by starting use at a young age. Parity, age at menarche, family history of breast cancer, or history of benign breast disease did not modify the effect of oral contraceptives on breast‐cancer risk. Relative risk estimates were slightly, although not significantly, increased during the first few years after starting oral contraception and in women under 35 years of age at diagnosis.
Defining the Focus of Attention: Effects of Attention on Perceived Exertion and Fatigue

This manuscript presents two experiments designed to explore the effects of attention on perceived exertion and time to failure in a fatiguing athletic task. There were two major motivating factors for these experiments. First, there are few studies evaluating attentional focus effects in endurance tasks and, second, there is a lack of integration between studies of attentional focus as external/internal (e.g., Wulf, 2007a) compared to associative/dissociative (e.g., Stevinson and Biddle, 1998). In Experiment 1, we used a fatiguing wall-sit posture (essentially a complex, isometric task) to compare two different types of external attention with an internal focus on the position of the legs. An external focus (regardless of type) increased the time taken to failure and reduced perceived exertion. In Experiment 2, we manipulated subjects’ expectancy of fatigue to test the interaction of attention and expectancy (both top-down factors) in this highly fatiguing task. Previous theories of attention during endurance tasks have suggested that as fatigue/pain increase, bottom-up factors begin to dominate subjects’ attention. While this may be true, Experiment 2 showed that even in a highly fatiguing task, attentional strategies, and expectancies affected the time to failure and perceived exertion.
Age of Onset of Mood Disorders and Complexity of Personality Traits

Objective. The aim of the present study is to evaluate the link between the age of onset of mood disorders and the complexity of the personality traits. Methods. 209 patients with major depressive or manic/hypomanic episodes were assessed using the Structured Clinical Interview for DSM Axis I diagnoses and the Millon Clinical Multiaxial Inventory-III (MCMI-III). Results. 17.2% of the patients had no elevated MCMI-III scores, 45.9% had one peak, and 36.9% had a complex personality disorder with two or more elevated scores. Mood disorders onset of 29 years or less was the variable most related to the complexity of personality disorders as indicated from a recursive partitioning analysis. Conclusions. The relationship between mood disorders and personality traits differ in reference to age of onset of the mood disorder. In younger patients, maladaptive personality traits can evolve both in a mood disorder onset and in a complex personality disorder, while the later development of a severe mood disorder can increase the personality symptomatology. Our results suggest a threshold of mood disorder onset higher compared to previous studies. Maladaptive personality traits should be assessed not only during adolescence but also in young adults to identify and treat potential severe mood disorders.