Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone Marrow Derived Kit-positive Cells Colonize the Gut but Fail to Restore Pacemaker Function in Intestines Lacking Interstitial Cells of Cajal

Background/Aims Several motility disorders are associated with disruption of interstitial cells of Cajal (ICC), which provide important functions, such as pacemaker activity, mediation of neural inputs and responses to stretch in the gastrointestinal (GI) tract. Restoration of ICC networks may be therapeutic for GI motor disorders. Recent reports have suggested that Kit+ cells can be restored to the GI tract via bone marrow (BM) transplantation. We tested whether BM derived cells can lead to generation of functional activity in intestines naturally lacking ICC. Methods BM cells from Kit+/copGFP mice, in which ICC are labeled with a green fluorescent protein, were transplanted into W/WV intestines, lacking ICC. After 12 weeks the presence of ICC was analyzed by immunohistochemistry and functional analysis of electrical behavior and contractile properties. Results After 12 weeks copGFP+ BM derived cells were found within the myenteric region of intestines from W/WV mice, typically populated by ICC. Kit+ cells failed to develop interconnections typical of ICC in the myenteric plexus. The presence of Kit+ cells was verified with Western analysis. BM cells failed to populate the region of the deep muscular plexus where normal ICC density, associated with the deep muscular plexus, is found in W/WV mice. Engraftment of Kit+-BM cells resulted in the development of unitary potentials in transplanted muscles, but slow wave activity failed to develop. Motility analysis showed that intestinal movements in transplanted animals were abnormal and similar to untransplanted W/WV intestines. Conclusions BM derived Kit+ cells colonized the gut after BM transplantation, however these cells failed to develop the morphology and function of mature ICC.
Observations on the Hipparion Red Clays of the Loess Plateau

We discuss the history of exploration of Red Clay vertebrate fossils of the Loess Plateau, and record observations on “Hipparion Red Clay” localities of Shanxi and Gansu provinces. Red clay is widespread across the Loess Plateau, but misleading as a descriptive term because many deposits are neither red nor dominated by clay-size sediment. Many red clay sequences contain paleosols, but also water-laid deposits. Our survey includes well-known localities of Yushe Basin, Renjiagou and Leijiahe near Lingtai, and sites of Qingyang and Qin’an. We discuss fossils found at Renjiagou, a new discovery of micromammals (Pliopentalagus) from Yucun, and Pliocene burrows observed at Hu Jia Cun, both latter localities northeast of Lingtai. Observations are consistent with a high rate of supply of clay sized particles, likely air-fall origin, throughout the Loess Plateau during the late Miocene. In some areas where fluvial or lake processes dominate, red clay particles are replaced in part or completely by water-laid coarse-grained deposits. We saw no evidence for a dry Late Miocene-Early Pliocene, but rather hypothesize well-watered habitat of high productivity. Locally diverse vertebrate fossils attest to high terrestrial biomass for Hipparion faunas.
Discourse Semantics with Information Structure

The property of projection poses a challenge to formal semantic theories, due to its apparent non-compositional nature. Projected content is therefore typically analyzed as being different from and independent of asserted content. Recent evidence, however, suggests that these types of content in fact closely interact, thereby calling for a more integrated analysis that captures their similarities, while respecting their differences. Here, we propose such a unified, compositional semantic analysis of asserted and projected content. Our analysis captures the similarities and differences between presuppositions, anaphora, conventional implicatures and assertions on the basis of their information structure, that is, on basis of how their content is contributed to the unfolding discourse context. We formalize our analysis in an extension of the dynamic semantic framework of Discourse Representation Theory (DRT)—called Projective DRT (PDRT)—that employs projection variables to capture the information-structural aspects of semantic content; different constellations of such variables capture the differences between the different types of projected and asserted content within a single dimension of meaning. We formally derive the structural and compositional properties of PDRT, as well as its semantic interpretation. By instantiating PDRT as a mature semantic formalism, we argue that it paves way for a more focused investigation of the information-structural aspects of meaning.
Effects of statins on cancer mortality and progression: A systematic review and meta‐analysis of 95 cohorts including 1,111,407 individuals

Statins have been implicated in the regulation of cell proliferation, apoptosis and tumor progression in cancer patients and statin use at the time of cancer diagnosis has been reported to be associated with reduced cancer risk and improved survival, irrespective of concomitant anti‐cancer therapy. A systematic literature search of relevant databases through May 2015 was conducted to identify studies assessing the prognostic impact of statin use on prognostic outcomes in cancer patients. Literature search identified 95 cohort studies that met the inclusion criteria. A meta‐analysis of 55 articles showed that statin use was significantly associated with decreased risk of all‐cause mortality (HR 0.70, 95% Cl 0.66 to 0.74) compared with nonusers. The observed pooled estimates were retained for cancer‐specific mortality (HR 0.60, 95% Cl 0.47 to 0.77), progression‐free survival (HR 0.67, 95% Cl 0.56 to 0.81), recurrence‐free survial (HR 0.74, 95% Cl 0.65 to 0.83) and disease‐free survival (HR 0.53, 95% Cl 0.40 to 0.72). These associations almost remained consistent across those outcomes when stratified by publication type, tumour location, study design, sample size, initiation of statins, disease stage, research country, follow‐up duration or research hospital involved. Subgroup analyses according to initiation of statins showed postdiagnosis statin users (HR 0.65, 95% Cl 0.54 to 0.79) gained significantly more recurrence‐free survival benefit than prediagnosis statin users (HR 0.86, 95% Cl 0.77 to 0.96) (p for interaction = 0.018). Statin therapy has potential survival benefit for patients with malignancy. Further large‐scale prospective studies emphasising survival outcomes of individual cancer type are strongly encouraged.
Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation

Objective The second messenger cAMP is involved in both β3 adrenoceptor (β3-AR) mediated detrusor relaxation and the kinetics of Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Here we characterized the effect HCN channel activation and possible interaction with β3-AR in bladder. Materials and Methods Bladder tissues from Sprague-Dawley rats and Human organ donors were obtained for studying species-specific expression of HCN channels by real-time qPCR and Western Blot. Effect of β3-agonist on rat bladder strips (0.5 × 0.5 × 7 mm in size) was studied during activation and blockade of HCN channels by Lamotrigine and ZD7288, respectively. Results Expression of all four genes encoding for HCN channels (HCN1-4) was detected separately in bladder mucosa and detrusor from human and rat bladders. Species based differences were evident from relatively higher expression of HCN4 isoform in human bladder and that of HCN1 in rat bladder. Western blot confirmed the findings at mRNA level. Cumulative application β3-AR agonist CL316,243 produced a concentration dependent decrease in resting tension of rat bladder strips expressed as integral of mechanical activity. Pre-incubation of HCN channel blocker ZD 7288 opposed the relaxant effect of CL316,243, whereas co-administration of lamotrigine with CL316,243 at equal molar concentrations caused an additive decrease in resting tension. Cumulative addition of ZD7288 and lamotrigine in absence of CL316,243 showed opposing effects on detrusor contractility. Conclusions Species-specific differences were noted in expression of HCN channels in bladder. Opposing effects ZD7288 and Lamotrigine in the action of β3-AR agonist demonstrate possible functional interaction of HCN channels and β3-AR in detrusor contractility.
Sentiment classification using Comprehensive Attention Recurrent models

Sentiment classification has been a very hot topic in the field of natural language processing (NLP) and understanding in recent years. Recurrent neural networks (RNN) is a widely used tool to deal with the classification problem of variable-length sentences. The standard RNN can only access the preceding context of a sentence. In this paper, a new architecture termed Comprehensive Attention Recurrent Neural Networks (CA-RNN) which can store preceding, succeeding and local contexts of any position in a sequence is developed. The bidirectional recurrent neural networks (BRNN) is used to access the past and future information while a convolutional layer is employed to capture local information. The standard RNN is also replaced by two recently emerged RNN variants, namely long short-term memory (LSTM) and gated recurrent unit (GRU), to enhance the effectiveness of the new architecture. Another salient feature of the proposed model is that it can be trained end-to-end without any human intervention. It is very easy to be implemented. We conduct experiments on several sentiment-labeled datasets and analysis tasks. Experiment results demonstrate that capturing comprehensive contextual information can significantly enhance the classification accuracy compared with the standard recurrent models and the new models can achieve competitive performance compared with the state-of-the-art approaches.
Assessment of climate change impact on water resources in the Pungwe river basin

The Rossby Centre Regional Climate Model (RCA3) and the hydrological model HBV were linked to assess climate change impacts on water resources in the Pungwe basin until 2050. RCA3 was capable of simulating the most important aspects of the climate for a control period at the regional scale. At the subbasin scale, additional scalingwas needed. Three climate change experiments using ECHAM4-A2, B2 and CCSM3-B2 as input to RCA3 were carried out. According to the simulations annual rainfall in 2050 would be reduced by approximately 10% with increasing interannual variability of rainfall and dry season river flow and later onset of the rainy season. The ECHAM4-A2 driven experiment did also indicate a slight increase of high flows. If the results indeed reflect the future, they will worsen the already critical situation for water resources, regarding both floods and droughts. Uncertainties, however in the downscaled scenarios make it difficult to prioritize adaptation options. This calls for inclusion of more climate change experiments, in an ensemble of climate scenarios possibly by using a combination of dynamical and statistical downscaling of general circulation models, as well as extending the simulations to 2100 to further ensure robustness of the signal.
Practice of Epidemiology Challenges in the Estimation of the Annual Risk ofMycobacterium tuberculosis Infection in Children Aged Less Than 5 Years

© The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons. org/licenses/by/4.0), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Vol. 186, No. 8 DOI: 10.1093/aje/kwx153 Advance Access publication: May 19, 2017
Differences between multimedia and text-based assessments of emotion management: An exploration with the multimedia emotion management assessment (MEMA)

ABSTRACT People process emotional information using visual, vocal, and verbal cues. However, emotion management is typically assessed with text based rather than multimedia stimuli. This study (N = 427) presents the new multimedia emotion management assessment (MEMA) and compares it to the text-based assessment of emotion management used in the MSCEIT. The text-based and multimedia assessment showed similar levels of cognitive saturation and similar prediction of relevant criteria. Results demonstrate that the MEMA scores have equivalent evidence of validity to the text-based MSCEIT test scores, demonstrating that multimedia assessment of emotion management is viable. Furthermore, our results inform the debate as to whether cognitive saturation in emotional intelligence (EI) measures represents “noise” or “substance”. We find that cognitive ability associations with EI represent substantive variance rather than construct-irrelevant shared variance due to reading comprehension ability required for text-based items.
Pan-and-tilt self-portrait system using gesture interface

Digital cameras are widely used in desktop and notebook PCs. Taking self-portraits is one of the important function of such cameras, which allows users to capture memories, create art, and improve photography techniques. A desktop environment with a large display and a pan-and-tilt camera provides users with a good area for exploring more angles and postures while taking self-portraits. However, most of the existing camera interfaces of this type are limited to device-based systems (i.e., mouse and keyboard) that prevent users from efficiently controlling the camera while taking self-portraits. This study proposes a vision-based system equipped with a gesture interface that control a pan-and-tilt camera for taking self-portraits. This interface uses gestures, particularly slight hand movements (i.e., sweeps, circles, and waves), to control the pan, tilt, and shutter functions of the camera. The gesture-recognition achieved good efficiency in performance (less than 2ms) and the recognition rate (0.9 on average in lighting conditions range 100–200). Experimental results indicate that the proposed system effectively controls the options in a self-portrait camera, this approach provides significantly higher satisfaction, particularly in terms of the intuitive motion gestures, freedom, and enjoyment, than when using a hand-held remote control or a conventional mouse-based interface. The proposed system is a promising technique for taking self-portraits in a desktop environment.
Artificial Insemination in Dogs

In Artificial Insemination (AI) the semen is collected manually from a stud male and thereafter deposited (inseminated) in the female so that fertilization can occur in the absence of natural mating. Artificial Insemination, one of the earliest techniques for assisted reproduction in animals and humans, took longer to be implemented in dogs due to speciesspecific particularities. In past decades, progresses in the knowledge of canine physiology and new advances in canine semen technology allowed these services to become available worldwide. Hence, subsequent to the increase in the artificial insemination demand among dog breeders and owners and the broaden of the AI to preserved semen as a management tool in canine breeding, as through international exchange of frozen semen, inbreeding within breeds can be reduced. Therefore, with spread of canine AI dog, breeders now may select stud dogs from all over the world to improve their kennel genetics, without transport-associated stress to the animals. Also, it is possible to save semen from valuable dogs into sperm bank to be used in next generations, after their death or the peak of reproductive age. In addition, breeders also are aware of the sanitary benefits associated with AI. Avoiding direct contact between the male and female, AI also prevents the spread of sexually transmitted diseases, as those originated by Brucella canis or Herpes virus (Farstad, 2010; Linde Forsberg, 2005a). Although the first reports on AI in dogs subsequent to the Spallanzani experiments (in late XVIII century) appeared by the end of the fifties, reporting the use of fresh semen, or in the sixties, the use of frozen semen, only in the nineties this technique was introduced into dog breeding practice, particularly in USA and Nordic countries (Foote, 2002; England & Millar, 2008). The reproductive physiology of this species and unfavourable response of the dog sperm to freezing were the two major constraints to the initial efforts to improve the AI technique in dogs (Linde Forsberg, 2005a). A lot of research was performed in those areas, especially in the northern Europe, to overcome these issues, generating a large amount of information and allowing technical development, in particular in the canine semen technology. Nowadays, as a consequence of the demand for reproductive technologies, in particular the AI with fresh or refrigerate semen, this is a current service offered in the small animal veterinary practice.
Effects of single-dose, low-level laser therapy on pain associated with the initial stage of fixed orthodontic treatment: A randomized clinical trial

Objective The aim of this study was to assess the analgesic effect of a single application of low-level laser therapy (LLLT) on spontaneous pain and pain on chewing after placement of initial archwires. Methods Forty-two patients (26 women, 16 men) were randomly recruited for this split-mouth randomized clinical trial. Each patient received super-elastic nickel-titanium (NiTi) initial archwires (0.012, 0.014, 0.016, and 0.018-inch [in]) in the maxilla for leveling and alignment for an interval of 4 weeks between archwires. One side of the mouth was randomly designated as experimental, while the other side served as placebo. After insertion of each archwire, the experimental side was irradiated with a diode laser for 3 seconds each on 5 points facially and palatally per tooth, from the central incisor to first molar. On the placebo side, the laser device was held the same way but without laser application. A numerical rating scale was used to assess the intensity of spontaneous and masticatory pain for the following 7 days. The Mann-Whitney U test was used to compare pain scores between sides. Results Patients in the LLLT group exhibited significantly lower mean scores for spontaneous pain after insertion of the initial two archwires (0.012-in and 0.014-in NiTi; p < 0.05), while there was no significant difference for 0.016-in and 0.018-in wires between the LLLT and placebo groups. LLLT significantly reduced chewing pain scores (p < 0.05) for all archwires. Conclusions A single dose of LLLT considerably lessened postoperative pain accompanying the placement of super-elastic NiTi wires for initial alignment and leveling.
Optimizing Injectable Poly-L-Lactic Acid Administration for Soft Tissue Augmentation: The Rationale for Three Treatment Sessions

BACKGROUND The availability and variety of different injectable modalities has led to a dramatic increase in soft tissue augmentation procedures in recent years. Injectable poly-L-lactic acid (PLLA) is a synthetic, biodegradable polymer device approved in the United States for use in immunocompetent patients as a single regimen of up to four treatment sessions for correction of shallow to deep nasolabial fold contour deficiencies and other facial wrinkles. Injectable PLLA is also approved for restoration and/or correction of signs of facial fat loss (lipoatrophy) in individuals with HIV. METHODS The present article provides an overview of previous studies with injectable PLLA, and specifically focuses on the number of recommended treatment sessions and intervals between treatment sessions. The authors also provide two case studies to support their recommendations for an average of three treatment sessions. RESULTS Although the specific mechanisms remain hypothetical, injections of PLLA are believed to cause a cascade of cellular events that lead to collagen repair and subsequent restoration of facial volume. Because the development of a response to injectable PLLA is gradual and its duration of effect is long lasting, sufficient time between treatment sessions should be allocated to avoid overcorrection. CONCLUSION Studies of injectable PLLA support the hypothesized mode of operation, and the experience and clinical recommendations of the authors that suggest that three treatment sessions are an optimal regimen for use of injectable PLLA in the majority of patients.
Comparative Metagenomics of Anode-Associated Microbiomes Developed in Rice Paddy-Field Microbial Fuel Cells

In sediment-type microbial fuel cells (sMFCs) operating in rice paddy fields, rice-root exudates are converted to electricity by anode-associated rhizosphere microbes. Previous studies have shown that members of the family Geobacteraceae are enriched on the anodes of rhizosphere sMFCs. To deepen our understanding of rhizosphere microbes involved in electricity generation in sMFCs, here, we conducted comparative analyses of anode-associated microbiomes in three MFC systems: a rice paddy-field sMFC, and acetate- and glucose-fed MFCs in which pieces of graphite felt that had functioned as anodes in rice paddy-field sMFC were used as rhizosphere microbe-bearing anodes. After electric outputs became stable, microbiomes associated with the anodes of these MFC systems were analyzed by pyrotag sequencing of 16S rRNA gene amplicons and Illumina shotgun metagenomics. Pyrotag sequencing showed that Geobacteraceae bacteria were associated with the anodes of all three systems, but the dominant Geobacter species in each MFC were different. Specifically, species closely related to G. metallireducens comprised 90% of the anode Geobacteraceae in the acetate-fed MFC, but were only relatively minor components of the rhizosphere sMFC and glucose-fed MFC, whereas species closely related to G. psychrophilus were abundantly detected. This trend was confirmed by the phylogenetic assignments of predicted genes in shotgun metagenome sequences of the anode microbiomes. Our findings suggest that G. psychrophilus and its related species preferentially grow on the anodes of rhizosphere sMFCs and generate electricity through syntrophic interactions with organisms that excrete electron donors.
Daily stem diameter variations can predict the canopy water status of mature temperate trees

Direct evidence for the link between stem diameter variations (SDV) and the daily canopy water status, i.e., daily water potentials (Ψ), is rare, particularly for tall trees. It thus remains unclear up to what degree SDV readings are useful to estimate daily canopy Ψ. We measured SDV with point dendrometers at the stem base of tall, mature individuals of six European forest tree species in a near-natural temperate forest and compared them with daily canopy Ψ during the growing seasons of 2014 (wet) and 2015 (dry). Stem diameter variations were de-trended for growth with two different approaches leading to the so-called tree water deficit (TWD). We found that midday Ψ can be predicted from TWD, independent of the growth-de-trending procedure to obtain TWD from SDV. Further, daily TWD was a better indicator for daily midday Ψ, particularly under dry conditions, than maximum daily shrinkage, another common quantity derived from SDV. Based on data from six temperate tree species, we conclude that TWD measured at the stem base is a consistent proxy for daily canopy midday Ψ of tall trees over the entire range of measured conditions.