Miracle-dz/UniFAR-FTUs huggingface dataset:
Body Mass Index and Platelet Reactivity During Dual Antiplatelet Therapy With Clopidogrel or Ticagrelor

Introduction: Dual antiplatelet therapy (DAPT) is considered essential in clinical management of patients undergoing percutaneous coronary revascularization or acute coronary syndromes. However, the optimal platelet inhibition is not always obtained, with high residual platelet reactivity (HRPR) increasing stent thrombosis and recurrent ischemic events. Aim of this study was to investigate the impact of body mass index (BMI) on platelet reactivity in patients on DAPT. Methods: We included patients treated with acetylsalycilic acid (ASA) (100–160 mg) and clopidogrel (75 mg) or ticagrelor (90 mg twice a day) for acute coronary syndromes or drug-eluting stent implantation. Platelet reactivity was assessed at 30–90 days postdischarge by multiple-electrode aggregometry. HRPR for adenosine diphosphate (ADP) antagonists was defined as ADP test results >417 AU*min. HRPR for ASA was considered for ASPI test >862 AU*min. Results: Our population is represented by 498 patients, 308 (61.8%) were treated with clopidogrel and 190 (38.2%) with ticagrelor. Overall, higher BMI was related with younger age (P = 0.003), higher prevalence of diabetes mellitus (P < 0.001), hypercholesterolemia (P = 0.017), hypertension (P < 0.001), chronic therapy with angiotensin-receptor blockers (P = 0.019), calcium channel blockers (P = 0.003). Higher values of BMI directly related with hemoglobin (P = 0.02), triglycerides (P < 0.001), glycemia (P = 0.035), HbA1c (P < 0.001), and inversely related with high-density lipoprotein cholesterol (P = 0.01). BMI did not influence the effectiveness of ASA, whereas it was associated to a nonsignificant trend for higher platelet reactivity (r = 0.08, P = 0.08) for ADP antagonists. In fact, 111 patients (22.3%) displayed HRPR at ADP test (>417 AU*min) with no statistically significant difference according to BMI {20.3% vs. 27.1% vs. 25.7%, P = 0.28; adjusted odds ratio [OR] [95% confidence interval (CI)] = 1.19 [0.86–1.64], P = 0.30}. However, results were different when considering separately patients receiving clopidogrel or ticagrelor. In the clopidogrel-treated subgroup, significantly higher ADP-mediated aggregation values were found in patients with higher BMI (r = 0.14, P = 0.023) that emerged as an independent predictor of HRPR with clopidogrel [OR (95% CI), 1.45 (1.01–2.12), P = 0.049]. On the contrary, no impact of BMI was observed in the ticagrelor-treated subgroup for platelet reactivity (r = −0.036, P = 0.62) or the prevalence of HRPR [adjusted OR (95% CI), 0.73 (0.39–1.36), P = 0.32]. Conclusions: This study shows that among patients treated with DAPT for coronary artery disease, higher BMI is related to increased platelet reactivity and a higher prevalence of HRPR in clopidogrel-treated patients while not significantly influencing the effectiveness of ticagrelor or ASA.
Effect of C on the Martensitic Transformation in Fe-C Alloys in the Presence of Pre-Existing Defects: A Molecular Dynamics Study

Molecular dynamics simulations are used to investigate the atomic effects of carbon (C) addition in Fe on the martensitic phase transformation in the presence of pre-existing defects such as stacking faults and twin boundaries. The pre-existing defect structures in Fe-C alloys have the same effect on the atomistic mechanisms of martensitic transformation as in pure Fe. However, C addition decreases the martensitic transformation temperature. This effect is captured by characterizing three parameters at the atomic level: atomic shear stresses, atomic energy, and total energy as a function of temperature for face-centered-cubic (fcc) and body-centered-cubic (bcc) phases. The thermodynamic effect of fcc phase stabilization by C addition is revealed by the atomic energy at a particular temperature and total energy as a function of temperature. The barrier for fcc-to-bcc transformation is revealed by analysis of atomic shear stresses. The analysis indicates that addition of C increases the atomic shear stresses for atomic displacements during martensitic transformation, which in turn decreases the martensitic transformation temperature.
What Model for Entry in First-Price Auctions? A Nonparametric Approach

We develop a nonparametric approach that allows for discrimination among alternative models of entry in first-price auctions. Three models of entry are considered: those of Levin and Smith (1994), Samuelson (1985), and a new model in which the information received at the entry stage is imperfectly correlated with bidder valuations. We derive testable restrictions of these models based on how the pro-competitive selection effect shifts bidder valuation quantiles in response to an increase in the number of potential bidders.
Restoration of quinine‐stimulated fos‐immunoreactive neurons in the central nucleus of the amygdala and gustatory cortex following reinnervation or cross‐reinnervation of the lingual taste nerves in rats

Remarkably, when lingual gustatory nerves are surgically rerouted to inappropriate taste fields in the tongue, some taste functions recover. We previously demonstrated that quinine‐stimulated oromotor rejection reflexes and neural activity (assessed by Fos immunoreactivity) in subregions of hindbrain gustatory nuclei were restored if the posterior tongue, which contains receptor cells that respond strongly to bitter compounds, was cross‐reinnervated by the chorda tympani nerve. Such functional recovery was not seen if instead, the anterior tongue, where receptor cells are less responsive to bitter compounds, was cross‐reinnervated by the glossopharyngeal nerve, even though this nerve typically responds robustly to bitter substances. Thus, recovery depended more on the taste field being reinnervated than on the nerve itself. Here, the distribution of quinine‐stimulated Fos‐immunoreactive neurons in two taste‐associated forebrain areas was examined in these same rats. In the central nucleus of the amygdala (CeA), a rostrocaudal gradient characterized the normal quinine‐stimulated Fos response, with the greatest number of labeled cells situated rostrally. Quinine‐stimulated neurons were found throughout the gustatory cortex, but a “hot spot” was observed in its anterior–posterior center in subregions approximating the dysgranular/agranular layers. Fos neurons here and in the rostral CeA were highly correlated with quinine‐elicited gapes. Denervation of the posterior tongue eliminated, and its reinnervation by either nerve restored, numbers of quinine‐stimulated labeled cells in the rostralmost CeA and in the subregion approximating the dysgranular gustatory cortex. These results underscore the remarkable plasticity of the gustatory system and also help clarify the functional anatomy of neural circuits activated by bitter taste stimulation. J. Comp. Neurol. 522:2498–2517, 2014. © 2014 Wiley Periodicals, Inc.
Wasserstein Blue Noise Sampling

In this article, we present a multi-class blue noise sampling algorithm by throwing samples as the constrained Wasserstein barycenter of multiple density distributions. Using an entropic regularization term, a constrained transport plan in the optimal transport problem is provided to break the partition required by the previous Capacity-Constrained Voronoi Tessellation method. The entropic regularization term cannot only control spatial regularity of blue noise sampling, but it also reduces conflicts between the desired centroids of Vornoi cells for multi-class sampling. Moreover, the adaptive blue noise property is guaranteed for each individual class, as well as their combined class. Our method can be easily extended to multi-class sampling on a point set surface. We also demonstrate applications in object distribution and color stippling.
Code Inspection - A Review

A method of delivering oil from an off-shore well to the shore is provided which comprises the steps of (a) supplying oil from the well to a floating storage vessel stationed close to the well; and (b) transferring oil by means of a flexible pipeline from the floating storage vessel to a service tanker which plies between the shore and the floating storage vessel. An oil storage vessel is also provided which has (a) a flexible hose for delivery of oil, one end of said hose being adapted for connection to the oil storage capacity of the vessel; and (b) a support system over which a hose selected from said flexible hose and a further hose connected to said flexible hose may be carried so as to extend from the stern of the oil storage vessel towards another vessel. Apparatus for and methods of mooring such a vessel are also provided.
Floral colour signal increases short-range detectability of a sexually deceptive orchid to its bee pollinator

SUMMARY Orchids of the genus Ophrys are pollinated by males of solitary bees and wasps through sexual deception. The flowers mimic the behaviourally active compounds of the sex pheromone of receptive females and thus attract males that seek to copulate. Odour is the main attractant while visual stimuli have been assumed so far to play only a minor role. In contrast to most species of the genus, Heldreich's orchid Ophrys heldreichii, which is pollinated by males of the long-horned bee Tetralonia berlandi, possesses a bright pink perianth that appears conspicuous to a human observer. We investigated the role of this floral colour signal in pollinator attraction. We filmed approach flights of male bees to flowers in which we removed the original perianth and in which we substituted the perianth with an artificial one of a particular selected colour. At distances >30 cm, male search time correlated only with wind speed but not with the spectral parameters of the perianth, i.e. chromatic and green receptor-specific contrast. By contrast, in the close range (<30 cm), where the perianth subtends a visual angle of at least 5 deg. to the bee's eye, search time decreased with increasing green receptor contrast between perianth and background; however, no correlation with chromatic contrast or wind speed was found. Our results indicate that pollinators are first attracted by olfactory signals from a distance. Once in the vicinity of the flower where spatial vision of the males is sufficient, they are guided exclusively by vision. However, it can be expected that possession of a `non-private' colour signal would increase the risk of pollen loss in sexually deceptive orchids by accidentally attracting non-specific flower visitors. We therefore discuss the occurrence of colour signals in the genus Ophrys in respect to the species-specific visual system of the pollinators.
Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side

Abstract Molecular medicine has entered a high-tech age that provides curative treatments of complex genetic diseases through genetically engineered cellular medicinal products. Their clinical implementation requires the ability to stably integrate genetic information through gene transfer vectors in a safe, effective and economically viable manner. The latest generation of Sleeping Beauty (SB) transposon vectors fulfills these requirements, and may overcome limitations associated with viral gene transfer vectors and transient non-viral gene delivery approaches that are prevalent in ongoing pre-clinical and translational research. The SB system enables high-level stable gene transfer and sustained transgene expression in multiple primary human somatic cell types, thereby representing a highly attractive gene transfer strategy for clinical use. Here we review several recent refinements of the system, including the development of optimized transposons and hyperactive SB variants, the vectorization of transposase and transposon as mRNA and DNA minicircles (MCs) to enhance performance and facilitate vector production, as well as a detailed understanding of SB’s genomic integration and biosafety features. This review also provides a perspective on the regulatory framework for clinical trials of gene delivery with SB, and illustrates the path to successful clinical implementation by using, as examples, gene therapy for age-related macular degeneration (AMD) and the engineering of chimeric antigen receptor (CAR)-modified T cells in cancer immunotherapy.
Scientific Evidence Base for Cartilage Injury and Repair in the Athlete

Soccer players and athletes in high-impact sports are frequently affected by knee injuries. Injuries to the anterior cruciate ligament and menisci are frequently observed in soccer players and may increase the risk of developing an articular cartilage lesion. In high-level athletes, the overall prevalence of knee articular cartilage lesions has been reported to be 36% to 38%. The treatment for athletic patients with articular cartilage lesions is often challenging because of the high demands placed on the repair tissue by impact sports. Cartilage defects in athletes can be treated with microfracture, osteochondral grafting, and autologous chondrocyte implantation. There is increasing scientific evidence for cartilage repair in athletes, with more extensive information available for microfracture and autologous chondrocyte implantation than for osteochondral grafting. The reported rates and times to return to sport at the preinjury level are variable in recreational players, with the best results seen in younger and high-level athletes. Better return to sport is consistently observed for all repair techniques with early cartilage repair. Besides minimizing sensorimotor deficits and addressing accompanying pathologies, the quality of the repair tissue may be a significant factor for the return to sport.
Titanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts

Abstract The use of nanoparticles in consumer products increases their prevalence in the environment and the potential risk to human health. Although recent studies have shown in vivo and in vitro toxicity of titanium dioxide nanoparticles (nano-TiO2), a more detailed view of the underlying mechanisms of this response needs to be established. Here, the effects of nano-TiO2 on the DNA damage response and DNA replication dynamics were investigated in human dermal fibroblasts. Specifically, the relationship between nano-TiO2 and the DNA damage response pathways regulated by ATM/Chk2 and ATR/Chk1 was examined. The results show increased phosphorylation of H2AX, ATM, and Chk2 after exposure. In addition, nano-TiO2 inhibited the overall rate of DNA synthesis and frequency of replicon initiation events in DNA-combed fibres. Taken together, these results demonstrate that exposure to nano-TiO2 activates the ATM/Chk2 DNA damage response pathway.
Anesthesia for Wolff-Parkinson-White syndrome: A report of two cases

1. Spennato P, Rapanà A, Sannino E, Iaccarino C, Tedeschi E, Massarelli I, et al. Retropharyngeal cerebrospinal fluid collection as a cause of postoperative dysphagia after anterior cervical discectomy. Surg Neurol 2007;67:499‐503. 2. Cavus E, Callies A, Doerges V, Heller G, Merz S, Rösch P, et al. The C‐MAC videolaryngoscope for prehospital emergency intubation: A prospective, multicentre, observational study. Emerg Med J 2011;28:650‐3. 3. Rosenstock CV, Thøgersen B, Afshari A, Christensen AL, Eriksen C, Gätke MR. Awake fiberoptic or awake video laryngoscopic tracheal intubation in patients with anticipated difficult airway management: A randomized clinical trial. Anesthesiology 2012;116:1210‐6. 4. Aziz MF, Dillman D, Fu R, Brambrink AM. Comparative effectiveness of the C‐MAC video laryngoscope versus direct laryngoscopy in the setting of the predicted difficult airway. Anesthesiology 2012;116:629‐36. 5. Healy DW, Picton P, Morris M, Turner C. Comparison of the glidescope, CMAC, storz DCI with the Macintosh laryngoscope during simulated difficult laryngoscopy: A manikin study. BMC Anesthesiol 2012;12:11. stenosis, this imposes even the most challenging airway problem for anesthesiologist. All findings were present in our patient. In addition, our patient also had altered phonation (laryngeal nerve involvement) and dysphagia (high risk for aspiration) thus making airway topicalization rather contraindicated and made this case even more challenging. Though considered as the gold standard, we could not achieve successful intubation with flexible fiber‐optic scope. The C‐MAC video laryngoscope is found to be useful in many difficult airway situations and equally effective as compared to flexible fiber‐optic intubation. [2,3] A recent study also revealed that there were higher chances of successful intubation on first attempt with the C‐MAC in many difficult intubation conditions. [4] In other studies, use of the glide scope resulted in longer time to successful intubation as compared to C-MAC blades. [5] In our patient also, C-MAC video laryngoscope could show us a better view of laryngeal inlet and even bougie could easily be negotiated through the vocal cords.
3DVAR and Cloud Analysis with WSR-88D Level-II Data for the Prediction of the Fort Worth, Texas, Tornadic Thunderstorms. Part II: Impact of Radial Velocity Analysis via 3DVAR

Abstract In this two-part paper, the impact of level-II Weather Surveillance Radar-1988 Doppler (WSR-88D) radar reflectivity and radial velocity data on the prediction of a cluster of tornadic thunderstorms in the Advanced Regional Prediction System (ARPS) model is studied. Radar reflectivity data are used primarily in a cloud analysis procedure that retrieves the amount of hydrometeors and adjusts in-cloud temperature, moisture, and cloud fields, while radial velocity data are analyzed through a three-dimensional variational (3DVAR) data assimilation scheme that contains a 3D mass divergence constraint in the cost function. In Part I, the impact of the cloud analysis and modifications to the scheme are discussed. In this part, the impact of radial velocity data and the mass divergence constraint in the 3DVAR cost function are studied. The case studied is that of the 28 March 2000 Fort Worth tornadoes. The addition of the radial velocity improves the forecasts beyond that experienced with the cloud analys.
Age and ethnic variations in sebaceous lipids

This study was conducted to compare lipid components of sebum from persons from three ethnic backgrounds—Caucasian, African American and Northern Asian. Men and women with no acne in two age groups (18‒25 y and 35‒45 y) were recruited. Skin surface hydration (SkiCon 200EX and NovaMeter), barrier function (Delfin VapoMeter), high-resolution clinical imaging, self-assessments and two pairs of sebutapes on the forehead that extracted the lipids on the surface of their skin were used. Significant differences (p < 0.05) in skin hydration between African Americans and Caucasians in both age groups were noted, with the order from highest to lowest absolute values: African American > Northern Asian > Caucasian. Transepidermal water loss (TEWL) measurements demonstrated that African Americans and Caucasians were significantly different (p < 0.05), with the trend being the inverse of the hydration trend—Caucasian > Northern Asian > African American, which would indicate better barrier function for African Americans with a lower TEWL. African American women had more total lipid production than Northern Asian or Caucasian women. When analyzing the three lipid classes (free fatty acids, triglycerides and wax esters), the trend became significant (p < 0.05) in the wax ester fraction when directly comparing African Americans with Caucasians. Additionally, six lipids were identified in the wax ester fractions that were significantly different in quantity (p < 0.05) between African Americans and Caucasians. These results identified significant differences in sebaceous lipid profiles across ethnic groups and determined that the differences correlated with skin barrier function.
A longitudinal study of nutritional and inflammatory status in patients on dialysis.

OBJECTIVE Several anthropometric, laboratory and bioelectrical impedance parameters of nutritional status and inflammation are often used as prognostic indices in patients on dialysis. Their longitudinal assessment is necessary for the estimation of their true prognostic value. We aim to estimate this prognostic value in better-nourished dialysis patients, which are commonly under-represented in pertinent studies. METHODS The design is a prospective case series. Pertinent parameters were studied three times during a 20-month period in 47 haemodialysis (HD) and 27 peritoneal dialysis (PD) patients with a low malnutrition-inflammation score (MIS). Mortality rate was assessed three years after the initial evaluation. Correlation coefficients were calculated between mortality rate, the studied parameters and their alteration. RESULTS Serum albumin of less than 40 g/l was strongly correlated with mortality risk. The alteration of studied parameters during a short period of time does not allow for long-term prediction of mortality risk. CONCLUSION Serum albumin had the strongest predictive value of all the pertinent parameters in the study. Thus, better conjugate clinical and laboratory measurements should be developed for patients on PD, as well as for those with a relatively low MIS.
Phylogenetic Investigations on Ten Genera of Tintinnid Ciliates (Ciliophora: Spirotrichea: Tintinnida), Based on Small Subunit Ribosomal RNA Gene Sequences

Tintinnida is a diverse taxon that accommodates over 1,500 morphospecies, which is an important component of marine planktonic food webs. However, evolutionary relationships of tintinnids are poorly known because molecular data of most groups within this order are lacking. In our study, the small subunit (SSU) rRNA genes representing 10 genera, 5 families of Tintinnida were sequenced, including the first SSU rRNA gene sequences for Coxliella, Dadayiella, Epiplocyloides, and Protorhabdonella, and phylogenetic trees were constructed to assess their intergeneric relationships. Phylogenies inferred from different methods showed that (1) Three newly sequenced Eutintinnus species fell into Eutintinnus clade forming a sister group to the clade containing Amphorides, Steenstrupiella, Amphorellopsis, and Salpingella; (2) Surprisingly, the genetic distances between Amphorides amphora and Amphorellopsis acuta population 1 was even smaller than that between the two populations of Amphorellopsis acuta, casting doubt on the validity of Amphorides and Amphorellopsis as presently defined; (3) The SSU rRNA sequences of Dadayiella ganymedes and Parundella aculeata were almost identical. Therefore, Parundella ganymedes novel combination is proposed; (4) Coxliella, which is currently assigned within Metacylididae, branched instead with some Tintinnopsis species. Furthermore, the validation of Coxliella, which was considered to be a “questionable” genus, was confirmed based on evidences from morphology, ecology, and molecular data; (5) Protorhabdonella and Rhabdonella showed rather low intergeneric distance and grouped together with strong support suggesting that Rhabdonellidae is a well‐defined taxon; and (6) Epiplocyloides branched with species in Cyttarocylididae indicating their close relationship.