Miracle-dz/UniFAR-FTUs huggingface dataset:
Members of the NAP/SET family of proteins interact specifically with B- type cyclins

Cyclin-dependent kinase complexes that contain the same catalytic subunit are able to induce different events at different times during the cell cycle, but the mechanisms by which they do so remain largely unknown. To address this problem, we have used affinity chromatography to identify proteins that bind specifically to mitotic cyclins, with the goal of finding proteins that interact with mitotic cyclins to carry out the events of mitosis. This approach has led to the identification of a 60-kD protein called NAP1 that interacts specifically with members of the cyclin B family. This interaction has been highly conserved during evolution: NAP1 in the Xenopus embryo interacts with cyclins B1 and B2, but not with cyclin A, and the S. cerevisiae homolog of NAP1 interacts with Clb2 but not with Clb3. Genetic experiments in budding yeast indicate that NAP1 plays an important role in the function of Clb2, while biochemical experiments demonstrate that purified NAP1 can be phosphorylated by cyclin B/p34cdc2 kinase complexes, but not by cyclin A/p34cdc2 kinase complexes. These results suggest that NAP1 is a protein involved in the specific functions of cyclin B/p34cdc2 kinase complexes. In addition to NAP1, we found a 43-kD protein in Xenopus that is homologous to NAP1 and also interacts specifically with B-type cyclins. This protein is the Xenopus homolog of the human SET protein, which was previously identified as part of a putative oncogenic fusion protein (Von Lindern et al., 1992).
The Influence of Selection Silviculture Biomass Harvesting on Soil Carbon, Nutrients, and Respiration in a Northern Mixed- Deciduous Forest

Concerns have been raised about soil fertility following increased recovery of biomass in northern mixed deciduous forests. Several studies suggest that biomass extraction and enhanced decomposer activity can lead to losses of soil C and nutrients, increased nitrification, and reduced soil CO2 efflux (FCO2) from compaction and root senescence. However, results are inconsistent; differences may be linked to insufficient investigation and characterisation of variability in forest structure, silvicultural methods, and intensity and heterogeneity of disturbances. Without a comprehensive understanding of how soil biogeochemical processes respond to different types and intensities of harvesting disturbances, we cannot accurately predict losses and ecological sustainability of harvesting. My thesis tests this by evaluating changes to forest structure and various soil edaphic and physical properties following treelength (TL) and more intensive biomass selection-harvests for 3 years and on primary and tertiary skid
A practical structured light acquisition system for point-based geometry and texture

We present a simple and high-quality 3D scanning system based on structured light. It uses the common setup of a video projector, a computer-controlled turntable and a single camera. Geometry is acquired using a combination of gray code and phase-shift projections, and it is stored and processed in a point-based representation. We achieve high accuracy by careful calibration of camera, projector, and turntable axis. In addition, we make use of the projector's calibration and extend it to a calibrated light source, allowing for a simple reconstruction of material properties for each surface point. We alternatively use a Lambertian reflectance model, or fit a Phong reflectance model to the samples under different turntable orientations. The acquisition pipeline is entirely point-based, avoiding the need of triangulation during all processing stages.
Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells

Granulocyte macrophage colony-forming cells (GM-CFC) have the potential to develop into either macrophages and/or neutrophils. With a highly enriched population of these cells we have found that although GM-CFC are equally responsive to macrophage colony stimulating factor (M-CSF) and stem cell factor (SCF) in terms of DNA synthesis, M-CSF stimulated the development of colonies containing macrophages in soft gel assays, while SCF promoted neutrophilic colony formation. When SCF and M-CSF were combined, mainly macrophage development was stimulated both in soft agar colony-forming assays and liquid cultures. An analysis of some potential signaling mechanisms associated with cytokine-mediated developmental decisions in GM-CFC revealed that M-CSF, but not SCF, was able to chronically stimulate phosphatidylcholine breakdown and diacylglycerol production, indicating that protein kinase C (PKC) may be involved in the action of M-CSF. Furthermore, M-CSF, but not SCF, can increase the levels of PKC alpha (PKC alpha) expression and stimulate the translocation of PKC alpha to the nucleus. When the PKC inhibitor, calphostin C, was added to GM-CFC cultured in M-CSF then predominantly neutrophils were produced, conversely PKC activators added with SCF stimulated macrophage development. The data indicate a role for PKC in M-CSF-stimulated macrophage development from GM-CFC.
Mitigating Silent Data Corruptions in Integer Matrix Products: Toward Reliable Multimedia Computing on Unreliable Hardware

The generic matrix multiply (GEMM) routine comprises the compute and memory-intensive parts of many information retrieval, machine learning, and object recognition systems that process integer inputs. Therefore, it is of paramount importance to ensure that integer GEMM computations remain robust to silent data corruptions (SDCs), which stem from accidental voltage or frequency overscaling, or other hardware nonidealities. In this paper, we introduce a new method for SDC mitigation based on the concept of numerical packing. The key difference between our approach and all existing methods is the production of redundant results within the numerical representation of the outputs, rather than as a separate set of checksums. Importantly, unlike well-known algorithm-based fault tolerance approaches for GEMM, the proposed approach can reliably detect the locations of the vast majority of all possible SDCs in the results of GEMM computations. An experimental investigation of voltage-scaled integer GEMM computations for visual descriptor matching within state-of-the-art image and video retrieval algorithms running on an Intel i7-4578U 3 GHz processor shows that SDC mitigation based on numerical packing leads to comparable or lower execution and energy-consumption overhead in comparison with all other alternatives.
On the stability of a Pexiderized functional equation in intuitionistic fuzzy Banach spaces 1

During the last few decades several researchers have been devoted to establishing stability of different kinds of functional equations, differential equations, functional differential equations, fractional differential equations, etc. under different sufficient conditions in different spaces like Banach spaces, Banach modules, fuzzy Banach spaces etc. In this paper, we remain confined in the discussion of stability of functional equations in intuitionistic fuzzy Banach spaces. Ulam was the first person who introduced an open question concerning the stability of a group homomorphism in an international conference. Thereafter several researchers have replied and are still replying to this open question in different contexts. The objective of the present paper is to determine the Hyers-Ulam-Rassias type stability concerning the Pexiderized functional equation in intuitionistic fuzzy Banach spaces. Under a few sufficient conditions, Hyers-Ulam-Rassias type stability of a Pexiderized functional equation has been established in intuitionistic fuzzy Banach spaces.
Cholinergic Enhancement Eliminates Modulation of Neural Activity by Task Difficulty in the Prefrontal Cortex during Working Memory

Previously, we demonstrated that enhancing cholinergic activity during a working memory (WM) task improves performance and reduces blood flow in the right anterior middle/superior frontal cortex, an area known to be important for WM. The purpose of this study was to evaluate the interaction between WM task demands and cholinergic enhancement on neural responses in the prefrontal cortex. Regional cerebral blood flow (rCBF) was measured using H215O and positron emission tomography, as 10 young healthy volunteers performed a parametrically varied match-to-sample WM for faces task. For each item, a picture of a face was presented, followed by a delay (1, 6, 11, or 16 sec), then by the presentation of two faces. Subjects were instructed to identify which face they previously had seen. For control items, nonsense pictures were presented in the same spatial and temporal manner. All conditions were performed during an intravenous infusion of saline and physostigmine (1 mg/hr). Subjects were blind to the substance being infused. Reaction time increased significantly with WM delay, and physostigmine decreased reaction time across delay conditions. Significant task-related rCBF increases during saline infusion were seen in superior frontal, middle frontal, and inferior frontal regions, and the response magnitudes in the regions increased systematically with task difficulty. In all of these prefrontal regions, physostigmine administration significantly reduced rCBF during task, particularly at longer task delays, so that no correlation between task delay and rCBF was observed. In the ventral visual cortex, physostigmine increased rCBF at longer task delays in medial regions, and decreased rCBF over delay conditions in lateral cortical areas. These results indicate that, during cholinergic potentiation, brain activity in prefrontal regions is not modulated by increases in WM task demands, and lends further support to the hypothesis that cholinergic modulation enhances visual processing, making the task easier to perform, and thus, compensate for the need to recruit prefrontal cortical regions as task demands increase.
Business model dynamics: a case survey

In the turbulent world of e-commerce, companies can only survive by continuously reinventing their business models. However, because most studies look at business models as snapshots in time, there is little insight into how changing market-related, technological and regulatory conditions generally drive revisions in business models. In this paper, we examine which types of external drivers are strongest in forcing business models to change throughout their life cycle. To do so, we study 45 longitudinal case descriptions on business model dynamics of (networks of) organizations in various industries. The results of this survey indicate that technological and market-related forces are the most important drivers of business model dynamics, while regulation plays only a minor role. In particular for start-ups, the effect of technological and market-related drivers is the strongest in the early stages of a new business model, while the effects are moderate over time for established, large companies. Our results provide clues to practitioners on what external factors to take into account in different stages of business model design and redesign.
Propagation of olfactory information in Drosophila

Investigating how information propagates between layers in the olfactory system is an important step toward understanding the olfactory code. Each glomerular output projection neuron (PN) receives two sources of input: the olfactory receptor neurons (ORNs) of the same glomerulus and interneurons that innervate many glomeruli. We therefore asked how these inputs interact to produce PN output. We used receptor gene mutations to silence all of the ORNs innervating a specific glomerulus and recorded PN activity with two-photon calcium imaging and electrophysiology. We found evidence for balanced excitatory and inhibitory synaptic inputs but saw little or no response in the absence of direct ORN input. We next asked whether any transformation of activity occurs at successive layers of the antennal lobe. We found a strong link between PN firing and dendritic calcium elevation, the latter of which is tightly correlated with calcium activity in ORN axons, supporting the idea of glomerular propagation of olfactory information. Finally, we showed that odors are represented by a sparse population of PNs. Together, these results are consistent with the idea that direct receptor input provides the main excitatory drive to PNs, whereas interneurons modulate PN output. Balanced excitatory and inhibitory interneuron input may provide a mechanism to adjust PN sensitivity.
Caractérisation expérimentale du phénomène d'autocicatrisation des fissures dans le béton

Principalement mis en evidence par des essais de permeabilite a l’eau jusqu’a present, le phenomene d’autocicatrisation des fissures dans les betons, lie a l’hydratation de ciment ou a la precipitation d’autres cristaux est ici etudie au travers d’essais mecaniques, sur un beton a ultra hautes performances. Des eprouvettes prismatiques entaillees sont endommagees par flexion 3 points en phase post pic, de facon a obtenir une ouverture de fissure residuelle comprise entre 5 et 15 µm. Apres vieillissement dans l’eau et dans l’air, pour differentes periodes, les eprouvettes sont ensuite retestees mecaniquement en flexion 3 points. Les resultats montrent clairement qu’il y a une reprise de raideur globale pour les eprouvettes conservees dans l’eau, alors que le comportement mecanique des eprouvettes conservees dans l’air n’a pas ete affecte. On explique cette reprise de rigidite, qui tend vers la rigidite des eprouvettes saines, par la cicatrisation de la fissure initialement formee. Une instrumentation emission acoustique permet egalement de confirmer les observations sur le phenomene au cours des essais mecaniques.
A phylogenetic hypothesis for passerine birds: taxonomic and biogeographic implications of an analysis of nuclear DNA sequence data

Passerine birds comprise over half of avian diversity, but have proved difficult to classify. Despite a long history of work on this group, no comprehensive hypothesis of passerine family–level relationships was available until recent analyses of DNA–DNA hybridization data. Unfortunately, given the value of such a hypothesis in comparative studies of passerine ecology and behaviour, the DNA–hybridization results have not been well tested using independent data and analytical approaches. Therefore, we analysed nucleotide sequence variation at the nuclear RAG–1 and c–mos genes from 69 passerine taxa, including representatives of most currently recognized families. In contradiction to previous DNA–hybridization studies, our analyses suggest paraphyly of suboscine passerines because the suboscine New Zealand wren Acanthisitta was found to be sister to all other passerines. Additionally, we reconstructed the parvorder Corvida as a basal paraphyletic grade within the oscine passerines. Finally, we found strong evidence that several family–level taxa are misplaced in the hybridization results, including the Alaudidae, Irenidae, and Melanocharitidae. The hypothesis of relationships we present here suggests that the oscine passerines arose on the Australian continental plate while it was isolated by oceanic barriers and that a major northern radiation of oscines (i.e. the parvorder Passerida) originated subsequent to dispersal from the south.
Shell shock at Queen Square: Lewis Yealland 100 years on

This article reviews the treatment of functional neurological symptoms during World War I by Lewis Yealland at the National Hospital for the Paralysed and Epileptic in London. Yealland was among the first doctors in Britain to incorporate electricity in the systematic treatment of shell shock. Our analysis is based on the original case records of his treatment of 196 soldiers with functional motor and sensory symptoms, functional seizures and somatoform disorders. Yealland’s treatment approach integrated peripheral and central electrical stimulation with a variety of other—psychological and physical—interventions. A combination of electrical stimulation of affected muscles with suggestion of imminent improvement was the hallmark of his approach. Although his reported success rates were high, Yealland conducted no formal follow-up. Many of the principles of his treatment, including the emphasis on suggestion, demonstration of preserved function and the communication of a physiological illness model, are encountered in current therapeutic approaches to functional motor and sensory symptoms. Yealland has been attacked for his use of electrical stimulation and harsh disciplinary procedures in popular and scientific literature during and after World War I. This criticism reflects changing views on patient autonomy and the social role of doctors and directly impacts on current debates on ethical justification of suggestive therapies. We argue that knowledge of the historical approaches to diagnosis and management of functional neurological syndromes can inform both aetiological models and treatment concepts for these challenging conditions.
Optimizing timing performance of silicon photomultiplier-based scintillation detectors

Precise timing resolution is crucial for applications requiring photon time-of-flight (ToF) information such as ToF positron emission tomography (PET). Silicon photomultipliers (SiPM) for PET, with their high output capacitance, are known to require custom preamplifiers to optimize timing performance. In this paper, we describe simple alternative front-end electronics based on a commercial low-noise RF preamplifier and methods that have been implemented to achieve excellent timing resolution. Two radiation detectors with L(Y)SO scintillators coupled to Hamamatsu SiPMs (MPPC S10362–33-050C) and front-end electronics based on an RF amplifier (MAR-3SM+), typically used for wireless applications that require minimal additional circuitry, have been fabricated. These detectors were used to detect annihilation photons from a Ge-68 source and the output signals were subsequently digitized by a high speed oscilloscope for offline processing. A coincident resolving time (CRT) of 147 ± 3 ps FWHM and 186 ± 3 ps FWHM with 3 × 3 × 5 mm3 and with 3 × 3 × 20 mm3 LYSO crystal elements were measured, respectively. With smaller 2 × 2 × 3 mm3 LSO crystals, a CRT of 125 ± 2 ps FWHM was achieved with slight improvement to 121 ± 3 ps at a lower temperature (15° C). Finally, with the 20 mm length crystals, a degradation of timing resolution was observed for annihilation photon interactions that occur close to the photosensor compared to shallow depth-of-interaction (DOI). We conclude that commercial RF amplifiers optimized for noise, besides their ease of use, can produce excellent timing resolution comparable to best reported values acquired with custom readout electronics. On the other hand, as timing performance degrades with increasing photon DOI, a head-on detector configuration will produce better CRT than a side-irradiated setup for longer crystals.
Adaptive Object Re-Ranking Mechanism for Ubiquitous Learning Environment

Ubiquitous Learning (U-Learning), as an emerging learning paradigm, makes it possible for learners to carry out the learning activities at any places and at anytime. With the advantages of the devices, learners can obtain a variety of supplementary materials from the Internet. In the scope of distance learning, LOR (Learning Object Repository) stands for managing and sharing of learning related materials (known as learning objects). However, some challenges may raise while performing these activities. For instance, a huge amount of learning objects may appear while learners utilize the search service provided by LOR. Learners have to spend time on collecting relevant resources for specific purposes. This situation may discourage the reusability of learning objects especially in a ubiquitous environment. In this paper, based on systematic re-examination of reuse scenarios, an adaptive mechanism, as a resource discovery and search middleware, was proposed to assist learners in obtaining possible objects under ubiquitous environment. Achievement of the proposed mechanism can produce search results adaptive to specific situations in order of similarity degree based on the mixed information. We try to filter out some irrelevant results by using the past usage history, current geographical information and input query, so as to enhance the efficiency of learning objects retrieval in a ubiquitous environment. As a pilot test, Apple iPhone was utilized to be the major client testbed.
Wireless network-coded four-way relaying using Latin Hyper-Cubes

This paper deals with physical layer network-coding for the four-way wireless relaying scenario where four nodes A, B, C and D wish to communicate their messages to all the other nodes with the help of the relay node R. The scheme given in the paper is based on the denoise-and-forward scheme proposed first by Popovski et al. in [1]. Intending to minimize the number of channel uses, the protocol employs two phases: Multiple Access (MA) phase and Broadcast (BC) phase with each phase utilizing one channel use. This paper does the equivalent for the four-way relaying scenario as was done for the two-way relaying scenario by Koike-Akino et al. [2], and for three-way relaying scenario in [3]. It is observed that adaptively changing the network coding map used at the relay according to the channel conditions greatly reduces the impact of multiple access interference which occurs at the relay during the MA phase. These network coding maps are so chosen so that they satisfy a requirement called exclusive law. We show that when the four users transmit points from the same M-PSK constellation, every such network coding map that satisfies the exclusive law can be represented by a 4-fold Latin Hyper-Cube of side M. The network code map used by the relay for the BC phase is explicitly obtained and is aimed at reducing the effect of interference at the MA stage.
Genetic variation among native chicken breeds of Iran based on biochemical polymorphisms

1. Genetic distances and heterozygosity were determined in 5 Iranian native chickens: Dashtyary, Lary, Marandy, Naked neck and Common breed, using three blood group systems (A, B and D) and 4 serum protein loci (albumin, transferrin, alkaline phosphatase and esterase). 2. The highest D A and D S were obtained between Dashtyary and Lary breeds. 3. The average heterozygosity for each breed in all loci ranged from 0·330 for Dashtyary to 0·370 for Common breed. 4. Dendrograms based on an unweighted pair-group method using an arithmetic average (UPGMA) showed two distinct clusters. One cluster included Dashtyary and the other contained the remaining 4 breeds.