Miracle-dz/UniFAR-FTUs huggingface dataset:
Requirements, Formal Verification and Model transformations of an Agent-based System: A CASE STUDY

One of the most challenging tasks in software specifications engineering for a multi-agent system is to ensure correctness. As these systems have high concurrency, often have dynamic environments, the formal specification and verification of these systems along with step-wise refinement from abstract to concrete concepts play major role in system correctness. Our objectives are the formal specification, analysis with respect to functional as well as non-functional properties by step-wise refinement from abstract to concrete specifications and then formal verification of these specifications. A multi-agent system is concurrent system with processes working in parallel with synchronization between them. We have worked on Gaia multi-agent method along with finite state process based finite automata techniques and as a result we have defined the formal specifications of our system, checked the correctness and verified all possible flow of concurrent executions of these specifications. Our contribution consists in transforming requirement specifications based on organizational abstractions into executable formal verification specifications based on finite automata. We have considered a case study of our multi-agent system to exemplify formal specifications and verification.
Working Memory Training in Schizophrenia and Healthy Populations

Cognitive deficits are consistently demonstrated in individuals with schizophrenia. Cognitive training involves structured exercises prescribed and undertaken with the intention of enhancing cognitive abilities such as attention, memory, and problem solving. Thus, cognitive training represents a potentially promising intervention for enhancing cognitive abilities in schizophrenia. However, cognitive training programs are numerous and heterogeneous, hence, the generalizability of training related outcomes can be challenging to assess. This article will provide a brief overview of current literature on cognitive training and explore how knowledge of working memory training in healthy populations can potentially be applied to enhance cognitive functioning of individuals with schizophrenia.
Karyological patterns in the European endemic genus Soldanella L.: Absolute genome size variation uncorrelated with cytotype chromosome numbers.

PREMISE OF THE STUDY Detailed knowledge about the karyological diversity of organisms undoubtedly represents one of the crucial steps toward a better understanding of their evolutionary trends and history. We investigated the cytotype and absolute genome size (AGS) patterns in the European mountain-dwelling genus Soldanella (Primulaceae) in light of its geographic distribution and ecological diversification. METHODS Our chromosome number survey was based on 34 newly determined and 125 previously published chromosome counts. AGS was estimated on the basis of propidium iodide (PI) flow cytometry (299 individuals, 110 populations). KEY RESULTS We confirmed the existence of two cytotypes with the same ploidy level, i.e., euploid 2n = 40 and dysploid 2n = 38. The overall infrageneric AGS variation ranged between 2.97 and 3.99 pg (25.6% variation). The 2n = 40 cytotype harbors a modest amount of continuous AGS variation. With regard to its distribution area and ecology, the cytotype is ubiquitous. By contrast, the 2n = 38 cytotype was detected only in six forest-dwelling taxa with AGS variation segregated into three discrete, geographically separated groups. The AGS variation of the 2n = 38 cytotype was strongly correlated with elevation and longitude. CONCLUSIONS Despite the apparent morphological and ecological variation, members of the genus Soldanella have not undergone any pronounced cytotype and AGS diversification during their evolutionary history. The lack of correlation between chromosome numbers and AGS indicates that the evolutionary mechanism behind the origin of the dysploid cytotype 2n = 38 was a chromosomal fusion.
Finite-Dimensional Approximation Settings for Infinite-dimensional Moore-Penrose Inverses

After a brief survey of basic results about finite-dimensional approximation settings (such as mathematical frameworks of various projection methods, including the least-squares method, the dual least-squares method, and the Galerkin method) for infinite-dimensional Moore-Penrose inverses, this paper proceeds to a detailed study from the following aspects: For projection methods, we investigate convergence and weak convergence of their approximation setting to develop a unified theory on projection methods for infinite-dimensional Moore-Penrose inverses; this investigation yields a fundamental convergence theorem (Theorem 2.2), from which the criterion for convergence, the criterion for weak convergence, and the generalized dual least-squares method are derived. We also derive general results on the least-squares method, by which two flaws in Groestch's results are corrected. For nonprojection methods (whose approximation setting is a more general framework), we investigate weak perfect convergence of their approximation setting and provide a necessary and sufficient condition of such convergence holding (Theorem 3.2). Several examples are proposed as counterexamples to illustrate the differences between some important concepts or as concrete algorithms to show how the present work can help to analyze their behavior.
Impaired sustained attention in euthymic bipolar disorder patients and non‐affected relatives: an fMRI study

Sepede G, De Berardis D, Campanella D, Perrucci MG, Ferretti A, Serroni N, Moschetta FS, Del Gratta C, Salerno RM, Ferro FM, Di Giannantonio M, Onofrj M, Romani GL, Gambi F. Impaired sustained attention in euthymic bipolar disorder patients and non‐affected relatives: an fMRI study. Bipolar Disord 2012: 14: 764–779. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S.
Software project economics: a roadmap

The objective of this paper is to consider research progress in the field of software project economics with a view to identifying important challenges and promising research directions. I argue that this is an important sub-discipline since this will underpin any cost-benefit analysis used to justify the resourcing, or otherwise, of a software project. To accomplish this I conducted a bibliometric analysis of peer reviewed research articles to identify major areas of activity. My results indicate that the primary goal of more accurate cost prediction systems remains largely unachieved. However, there are a number of new and promising avenues of research including: how we can combine results from primary studies, integration of multiple predictions and applying greater emphasis upon the human aspects of prediction tasks. I conclude that the field is likely to remain very challenging due to the people-centric nature of software engineering, since it is in essence a design task. Nevertheless the need for good economic models will grow rather than diminish as software becomes increasingly ubiquitous.
Hybrid Analog and Digital Beamforming for mmWave OFDM Large-Scale Antenna Arrays

Hybrid analog and digital beamforming is a promising candidate for large-scale millimeter wave (mmWave) multiple-input multiple-output (MIMO) systems because of its ability to significantly reduce the hardware complexity of the conventional fully digital beamforming schemes while being capable of approaching the performance of fully digital schemes. Most of the prior work on hybrid beamforming considers frequency-flat channels. However, broadband mmWave systems are frequency-selective. In broadband systems, it is desirable to design common analog beamformer for the entire band while employing different digital (baseband) beamformers in different frequency sub-bands. This paper considers the hybrid beamforming design for systems with orthogonal frequency division multiplexing modulation. First, for a single-user MIMO (SU-MIMO) system where the hybrid beamforming architecture is employed at both transmitter and receiver, we show that hybrid beamforming with a small number of radio frequency (RF) chains can asymptotically approach the performance of fully digital beamforming for a sufficiently large number of transceiver antennas due to the sparse nature of the mmWave channels. For systems with a practical number of antennas, we then propose a unified heuristic design for two different hybrid beamforming structures, the fully connected and the partially connected structures, to maximize the overall spectral efficiency of an mmWave MIMO system. Numerical results are provided to show that the proposed algorithm outperforms the existing hybrid beamforming methods, and for the fully connected architecture, the proposed algorithm can achieve spectral efficiency very close to that of the optimal fully digital beamforming but with much fewer RF chains. Second, for the multiuser multiple-input single-output case, we propose a heuristic hybrid percoding design to maximize the weighted sum rate in the downlink and show numerically that the proposed algorithm with practical number of RF chains can already approach the performance of fully digital beamforming.
Latitudinal clines in the grasshopper Dichroplus elongatus: Coevolution of the A genome and B chromosomes?

Argentine populations of Dichroplus elongatus (Orthoptera: Acrididae) are polymorphic for B chromosomes. Previous studies showed that B chromosomes affect body size and some fitness components in Northwestern populations. We studied phenotype and B′s variation patterns along a latitudinal cline as well as the relationship between karyotype and body size related traits in 17 populations from East.
Risk Factors for Postpartum Antihypertensive Medication Requirement in Severe Preeclampsia

Objective: To determine antepartum risk factors for postpartum antihypertensive medication use in women with severe preeclampsia. Methods: A case control study was performed on patients who were diagnosed with severe preeclampsia between January 2000 and June 2004 at a single tertiary care center. Women discharged from the hospital on antihypertensive medications were compared to women discharged home on no antihypertensive medications. Demographic data, maternal medical conditions, and delivery data were abstracted from maternal charts. Risk factors were evaluated using multiple logistic regression. Results: 218 patients with severe preeclampsia were identified, of which 112 were discharged on antihypertensives. After adjusting for confounding variables, chronic hypertension was associated with an increased need for post partum antihypertensive medication (OR 7.5 (95% CI 3.0–18.1)). A dose-dependent association was seen with intrapartum hydralazine administration. High-dose hydralazine was associated with increased need for postpartum antihypertensive mediation (OR 5.74 95% CI 2.03–16.2) compared to low-dose hydralazine (OR of 2.51 95% CI 1.26–5.01). Hemolysis/Elevated liver function/low platelet (HELLP) syndrome was associated with a decreased need for antihypertensive medication (OR 0.33, 95% CI 0.13–0.82). Conclusions: Patients with chronic hypertension and patients who required intrapartum hydralazine were more likely to require antihypertensive medications at discharge.
Does Rectal Indomethacin Given for Prevention of Post-ERCP Pancreatitis Increase Bleeding After Biliary Endoscopic Sphincterotomy or Cardiovascular Mortality?

AbstractRectal indomethacin has been proven to be effective for prevention of post-ERCP pancreatitis (PEP) but its impact on bleeding after biliary sphincterotomy (BABES) and cardiovascular mortality has not been extensively studied. We aimed to assess the effect of indomethacin on the rate of BABES and short-term cardiovascular mortality, particularly in patients receiving antiplatelet therapy (APT). In this double-blind, randomized, placebo-controlled, single-center study, 100 mg indomethacin or placebo was given within 1 hour before biliary endoscopic sphincterotomy to in-patients including those who are receiving APT (acetylsalicylic acid [ASA] and/or clopidogrel). Cardiovascular mortality and BABES were observed for 30 days.Of 576 randomized patients (289 indomethacin, 287 placebo), 87 patients used 100 mg/day ASA and 29 patients took 75 mg/day clopidogrel, among them 5 patients were on dual APT. The ASA and clopidogrel taking patients were older than patients without APT (P < 0.001), but these groups were similar in other parameters. BABES occurred similarly in different subgroups: indomethacin (8.0%) vs placebo (9.4%) (P = 0.56), ASA (10.3%) vs non-ASA (8.4%) (P = 0.54), clopidogrel (6.9%) vs nonclopidogrel (8.8%) (P > 0.99). No BABES was observed among patients on dual APT. There was no difference in cardiovascular mortality between subgroups (P > 0.99). Results indicate that single dose of 100 mg indomethacin does not increase BABES rate and cardiovascular mortality. This result is independent from administering antiplatelet agents.
Evaluation of potential factors affecting the measurement of cerebrovascular reactivity by near-infrared spectroscopy.

1.Near-infrared (IR) spectroscopy is based on the relative transparency of skin, skull and brain to the light in the near-IR region (700-1100 nm) and on the oxygen-dependent tissue absorption changes of haemoglobin.2. We evaluated the most relevant factors (reproducibility, venous return, age and sex) that might affect reliability of near-IR spectroscopy to test CO2 cerebrovascular reactivity.3. Thirty-four healthy volunteers were enrolled in the study. The protocol consisted of a 3-min baseline, a 3-min hypercapnia (5% CO2 in air) and a 2-min recovery. Transcranial Doppler sonography measurements were simultaneously performed. The CO2 reactivity test was repeated on 27 subjects after 1 h to assess reproducibility. CO2 reactivity was also evaluated at different body positions (supine, 35 degrees Trendelenburg and 35 degrees reverse Trendelenburg), and over a gradual increase of the inspired CO2.4. Changes in near-IR spectroscopy and transcranial Doppler sonography parameters were significantly correlated with variations of end-tidal CO2 (P<0.005). A significant correlation between the reactivity indexes of near-IR spectroscopy parameters and flow velocity was also found (P<0.01). A high reproducibility was also found for deoxyhaemoglobin (rI=0.76), oxyhaemoglobin (rI=0.68) and flow velocity (rI=0.60) reactivity indexes. No significant differences between the reactivity indexes of different body positions were found (P>0.05). The reactivity index of oxyhaemoglobin and deoxyhaemoglobin decreased (P<0.05) and increased (P<0.01) with age respectively.5. We found that near-IR spectroscopy is a reliable and reproducible method for the evaluation of cerebrovascular reactivity and might be considered, after appropriate validation, for the assessment of patients with cerebrovascular disease.
A general model for hydrogen trapping at the inclusion-matrix interface and its relation to crack initiation

Abstract The role of non-metallic inclusions in hydrogen-induced failure of structural materials has been a controversial topic for many years. In this paper, hydrogen trapping and its relation to the crack initiation at the inclusion-matrix interfaces are studied by considering the interfacial structure and the interaction between the dissolved hydrogen atoms and the elastic strains produced by lattice matching and misfit dislocations. A model is proposed to analyse the change of interfacial structure with inclusion size and its relation to hydrogen trapping. Hydrogen accumulation at the interfaces is quantitatively analysed. The obtained results are in good agreement with the experimental observations. The multiple factors, such as interfacial structure, chemical composition, elastic properties of matrix and inclusions, crystallographic relationship between inclusions and matrix, inclusion morphology and size, simultaneously control hydrogen trapping. In addition, the mechanism of hydrogen-induced crack initiation at the interface is investigated. A criterion is proposed to determine critical conditions for crack initiation. For the first time, the inherent relationship between hydrogen trapping and hydrogen-induced cracking at the interface is clarified. This work paves a way for an in-depth understanding of the effects of inclusions on hydrogen-induced degradation of mechanical properties.
Lagging adaptation to warming climate in Arabidopsis thaliana

Significance If adaptive evolution cannot keep up with rapid climate change, populations and even species may decline or go extinct. Such adaptational lag is predicted, but evidence is scarce. We tested for lagging adaptation to warming climate in banked seeds of the annual weed Arabidopsis thaliana in common garden experiments in four sites across the species’ native European climate range. Genotypes originating in climates historically warmer than the planting site had higher relative fitness than native genotypes in every site. This result suggests that local adaptive optima have shifted rapidly with recent climate warming across the species’ native range, and that the potential for adaptational lag deserves consideration in conservation and management decisions for many species. If climate change outpaces the rate of adaptive evolution within a site, populations previously well adapted to local conditions may decline or disappear, and banked seeds from those populations will be unsuitable for restoring them. However, if such adaptational lag has occurred, immigrants from historically warmer climates will outperform natives and may provide genetic potential for evolutionary rescue. We tested for lagging adaptation to warming climate using banked seeds of the annual weed Arabidopsis thaliana in common garden experiments in four sites across the species’ native European range: Valencia, Spain; Norwich, United Kingdom; Halle, Germany; and Oulu, Finland. Genotypes originating from geographic regions near the planting site had high relative fitness in each site, direct evidence for broad-scale geographic adaptation in this model species. However, genotypes originating in sites historically warmer than the planting site had higher average relative fitness than local genotypes in every site, especially at the northern range limit in Finland. This result suggests that local adaptive optima have shifted rapidly with recent warming across the species’ native range. Climatic optima also differed among seasonal germination cohorts within the Norwich site, suggesting that populations occurring where summer germination is common may have greater evolutionary potential to persist under future warming. If adaptational lag has occurred over just a few decades in banked seeds of an annual species, it may be an important consideration for managing longer-lived species, as well as for attempts to conserve threatened populations through ex situ preservation.
a-Tocopherol Content and a-Tocopherol Transfer Protein Expression in Leukocytes of Children with Acute Leukemia

α-Tocopherol (a form of vitamin E) is a fat-soluble vitamin that can prevent lipid peroxidation of cell membranes. This antioxidant activity of α-tocopherol can help to prevent cardiovascular disease, atherosclerosis and cancer. We investigated the α-tocopherol level and the expression of α-tocopherol transfer protein (α-TTP) in the leukocytes of children with leukemia. The plasma and erythrocyte α-tocopherol levels did not differ between children with leukemia and the control group. However, lymphocytes from children with leukemia had significantly lower α-tocopherol levels than lymphocytes from the controls (58.4±39.0 ng/mg protein versus 188.9±133.6, respectively; p<0.05), despite the higher plasma α-tocopherol/cholesterol ratio in the leukemia group (5.83±1.64 μmol/mmol versus 4.34±0.96, respectively; p<0.05). No significant differences in the plasma and leukocyte levels of isoprostanes (the oxidative metabolites of arachidonic acid) were seen between the leukemia patients and controls. The plasma level of acrolein, a marker of oxidative stress, was also similar in the two groups. Investigation of α-TTP expression by leukocytes using real-time PCR showed no difference between the two groups. These findings suggest that there may be comparable levels of lipid peroxidation in children with untreated leukemia and controls, despite the reduced α-tocopherol level in leukemic leukocytes.
Fungal Biofilms and Drug Resistance

Candida species, including the novel opportunistic pathogen Candida dubliniensis, are now emerging as major agents of nosocomial infections. Many such manifestations of infections associated with the formation of Candida biofilms include those occurring on devices such as indwelling intravascular catheters. Fungal biofilm-associated infections are frequently refractory to conventional therapy because of resistance to antimicrobial agents. This resistance could be in part due to the surface-induced upregulation of drug efflux pumps. Biofilm-associated Candida show uniform resistance to a wide spectrum of the currently available conventional antifungal agents, which implies that antimicrobial drugs that specifically target biofilm-associated infections are needed. The novel classes of antifungal agents, the lipid formulation of amphotericins, and the echinocandins have demonstrated unique antifungal activity against the resistant Candida biofilms, providing a breakthrough in the treatment of life-threatening invasive systemic mycoses. The use of drugs effective in combating biofilm-associated infections could lead to major developments in the treatment of fungal implant infections.
The geography and ecology of plant speciation: range overlap and niche divergence in sister species

A goal of evolutionary biology is to understand the roles of geography and ecology in speciation. The recent shared ancestry of sister species can leave a major imprint on their geographical and ecological attributes, possibly revealing processes involved in speciation. We examined how ecological similarity, range overlap and range asymmetry are related to time since divergence of 71 sister species pairs in the California Floristic Province (CFP). We found that plants exhibit strikingly different age-range correlation patterns from those found for animals; the latter broadly support allopatric speciation as the primary mode of speciation. By contrast, plant sisters in the CFP were sympatric in 80% of cases and range sizes of sisters differed by a mean of 10-fold. Range overlap and range asymmetry were greatest in younger sisters. These results suggest that speciation mechanisms broadly grouped under ‘budding’ speciation, in which a larger ranged progenitor gives rise to a smaller ranged derivative species, are probably common. The ecological and reproductive similarity of sisters was significantly greater than that of sister–non-sister congeners for every trait assessed. However, shifts in at least one trait were present in 93% of the sister pairs; habitat and soil shifts were especially common. Ecological divergence did not increase with range overlap contrary to expectations under character displacement in sympatry. Our results suggest that vicariant speciation is more ubiquitous in animals than plants, perhaps owing to the sensitivity of plants to fine-scale environmental heterogeneity. Despite high levels of range overlap, ecological shifts in the process of budding speciation may result in low rates of fine-scale spatial co-occurrence. These results have implications for ecological studies of trait evolution and community assembly; despite high levels of sympatry, sister taxa and potentially other close relatives, may be missing from local communities.