Miracle-dz/UniFAR-FTUs huggingface dataset:
Worker assignment optimization under reset limited-cycled model with multiple periods — Focus on worker's clever tasks

In uncertain cases, the result and efficiency of current period (or production cycle) are influenced not only by the risks which exist in current period but also by the risks which exist in the previous ones. What is more, the risk itself is also affected greatly by the risks which exist in the earlier periods. This kind of problem is called a limited-cycle problem with multiple periods. Normally, workers' efficiency is different on different tasks. How can we get an optimal assignment to minimize the total expected costs? In this paper, we consider the optimal worker assignment considering two kinds of efficiency, clever or poor efficiency on tasks. The regularity will be described that n-2 workers have two clever tasks of all, 2 worker has no clever task by contrast. Also, some numerical experiments will be done to check out the regularity of the optimal assignment that each worker has three clever tasks.
Desmoplastic Small Round Cell Tumor

Desmoplastic small round cell tumor (DSRCT) is an aggressive small round cell neoplasm which predominantly occurs intra-abdominally in adolescents and young adults with a male predominance, and which is characterized by a recurrent t(11;22)(p13;q12) translocation leading to formation of the EWSR1-WT1 fusion gene, which generates a chimeric protein with transcriptional regulatory activity. Histologically, DSRCT has a characteristic morphology, of islands of monotonous small cells within prominent sparsely cellular fibroblastic stroma, and immunohistochemically it shows polyphenotypic multidirectional differentiation, with expression of epithelial, muscle, and neural markers. However, DSRCT can arise more rarely in other sites and exhibit a spectrum of both histologic features and immunoprofile, which may confuse diagnosis with other small round cell neoplasms. Correct diagnosis is important to ensure correct treatment and prognostication; DSRCT are almost universally fatal neoplasms with patients usually succumbing to disease within the first 2 years of diagnosis. While combination treatment strategies can confer a survival benefit, the overall prognosis remains poor. Further insight into the tumorigenic molecular changes generated by the fusion oncogene may lead to the generation of specific targeted therapies. We review DSRCT, discussing morphology and immunohistochemistry, molecular genetic findings, potential targeted treatments, and the differential diagnosis.
IMPROVEMENTS IN ENGLISH ASR FOR THE MALACH PROJECT USING SYLLABLE-CENTRIC MODELS

LVCSR systems have traditionally used phones as the basic acoustic unit for recognition. Syllable and other longer length units provide an efficient means for modeling long-term temporal dependencies in speech that are difficult to capture in a phone based recognition framework. However, it is well known that longer duration units suffer from training data sparsity problems since a large number of units in the lexicon will have little or no acoustic training data. Previous research has shown that syllable-based modeling provides improvements over word internal systems, but performance has lagged behind crossword context-dependent systems. In this paper, we describe a syllable-centric approach to English LVCSR for the MALACH (Multilingual Access to Large spoken ArCHives) project. The combined modeling of syllables and context-dependent phones provides a 0.5% absolute improvement in recognition accuracy over the state-of-the-art cross word system for the heavily accented and spontaneous speech seen in oral history archives. More importantly, we report on the importance of the improved recognition of names and concepts that is crucial for subsequent search and retrieval.
Sub- and Supralexical Information in Early Phases of Lexical Access

The present study investigated sub- and supralexical effects in morphological processing for inflected and pseudo complex words and pseudo words in lexical decision with masked and cross-modal priming. The results showed that the early stage of morphological processing is not only sensitive to whether the orthographic string can be segmented into an existing stem and affix, but also whether the full form is an existing word the meaning of which differs from the meaning of the segmented stem. It is thus likely that from early on morphological processing is probably not governed by morpho-orthographic processes alone, but is most likely sensitive to top-down information, perhaps originating from supralexical semantic connections between the words morphological family members. In addition, whereas semantic interpretability has a clear advantage later in processing, this stage seems to be sensitive to bottom-up form information as well. In a detailed theoretical discussion we show how these findings, along with earlier findings, are explained by a model that assumes that morphological information is represented at two interactive levels, corresponding to sublexical form (orthographic) and supralexical (semantic) information mediated by a lexical level. This allows supralexical (semantic) effects to feed top-down, predicting differences between regular inflected and pseudo complex words at the lexical level, affecting the early phases of processing for these words.
Parallel Convolutional Neural Networks for Music Genre and Mood Classification

Our approach to the MIREX 2016 Train/Test Classification Tasks for Genre, Mood and Composer detection is based on an approach combining Melspectrogram transformed audio and Convolutional Neural Networks (CNN). We utilize two different CNN architectures, a sequential one, and a parallel one, the latter aiming at capturing both temporal and timbral information in two different pipelines, which are merged on a later stage. In both cases, the crucial CNN parameters such as filter kernel sizes and pooling sizes were carefully chosen after a range of experiments.
Shared Ambiguity but Different Experiences and Demands among Dental Students — A Gender Perspective

This study explores how dental students experience their clinical semesters from a gender perspective. Twelve students (seven women and five men) and three teachers (two women and one man) at the Umeå dentistry programme participated in semi-structured interviews that were analysed with Grounded Theory methodology. The model we propose consists of the core category experiencing ambiguity and the three categories experiencing pressure and stress, assessing your own performance, and passing through the eye of the needle as well as four subcategories. At the core of our findings lies ambiguity, captured in the student dilemmas what's enough/when's enough. The answers to these dilemmas are further complicated by the gendered dimension and the dimension of unequal treatment, which provide students with different and contradicting sets of rules and roles. A comparison with recent findings from the United States shows that the students' experiences are not unique. Our experiencing ambiguity model constitutes a platform for future research on how students experience clinical education, as well as potential predictors and consequences in relation to performance and well-being.
Transforming Work Experience in Higher Education

It has frequently been claimed that work experience can contribute to higher educational standards in schools and in higher education and contribute to the development of a flexible, highly-skilled and enterprising labour force. This potential was endorsed by the Dearing Report on higher education, although there is little research evidence about the contribution of work experience to the higher education curriculum. This article reports on four empirical studies of work experience in higher education, which suggest that work experience is related to a more positive view of the learning experience and to higher employment rates. However, retrospective views of graduates tend to be more positive than those of current undergraduates and there appear to be distinct subject variations in the impact of different types of work experience. It is argued that the potential is more likely to be realised where work experience placements have six characteristics of good practice and where the higher education curriculum consistently encourages students to reflect well on their own learning.
AN AUGMENTED REALITY BASED TELEOPERATION INTERFACE FOR UNSTRUCTURED ENVIRONMENTS

The general problem of managing a remotely situated vehicle or manipulator system is discussed, from the point of view of what level of autonomy is feasible. Assuming continued presence of a human operator (HO) in the loop, the advantages of Director / Agent (D/A) control are discussed, as a means of alleviating the tedium of conventional continuous manual teleoperation. In order to realise a viable D/A system, the HO must be able to communicate accurate quantitative 3D task related data to the robot controller. In an unstructured environment, such information is typically neither available a priori nor readily obtainable during task execution. An Augmented Reality display system is introduced as a means to obtain such quantitative measurement data online, via partial modelling of the remote site using a Virtual Tape Measure. Some of the design considerations for this system are discussed and sample measurement accuracy and precision data are presented.
Adaptive Zero Velocity Update Based on Velocity Classification for Pedestrian Tracking

Due to the drift of low-cost micro-electro-mechanical systems sensors and recursive computation, pedestrian tracking based on foot-mounted inertial sensors suffers from accumulative velocity and position errors. The well-known approach named zero velocity update (ZUPT) is able to minimize such errors by resetting the velocity to zero when the foot does not move with respect to ground. This time duration is called the still phase of a stride and can be detected by comparing the actual sensor data with a pre-defined threshold. However, when the velocity increases or decreases, the fixed threshold may be too small or too big for the correct detection of the still phase. Based on our previous study, this paper presents a novel adaptive ZUPT approach using an additional chest-attached accelerometer for consistent removal of accumulative errors even if the velocity changes. The information extracted from the chest acceleration is used to update corresponding threshold for the still-phase detection, and, hence, to determine error-free velocity and position information. The experimental results show that the accurate tracking trajectory can still be successfully obtained even if the velocity changes rapidly during the experiment.
Femtosecond Laser Assisted Deep Anterior Lamellar Keratoplasty Outcomes and Healing Patterns Compared to Manual Technique

The purpose of the study is to report the visual, refractive, and wound healing pattern outcomes of femtosecond assisted deep anterior lamellar keratoplasty (DALK) compared to the conventional manual technique. DALK was performed on 50 eyes of 47 advanced keratoconus patients. The patients were divided into two groups, 25 eyes each, depending on whether femtosecond assisted or manual DALK technique was performed for the side cut of the procedure only. Patients were followed up at 1 month, 6 months, and 1 year for visual acuity, clinical refraction, corneal cylinder, date of suture removal, and side cut corneal healing pattern according to new grading classification of the side cut scar (Grade 0 = transparent scar, 1 = faint healing opacity, 2 = evident healing opacity, 3 = significant opacity with some cosmetic imbalance, and 4 = highly significant opacity with very significant cosmetic imbalance). Outcomes are reported at one year. In conclusion, femtosecond assisted and manual DALK show comparable visual and refractive outcomes but femtosecond assisted DALK shows more evident corneal wound healing patterns at the side cut. This observation may indicate that an activated cornea wound healing might allow earlier suture removal when femtosecond technology is used to perform the side cut for DALK.
Motivation and Engagement Across the Academic Life Span

From a developmental construct validity perspective, this study examines motivation and engagement across elementary school, high school, and university/college, with particular focus on the Motivation and Engagement Scale (comprising adaptive, impeding/maladaptive, and maladaptive factors). Findings demonstrated developmental construct validity across the three distinct educational stages in terms of goodfitting first- and higher order factors, invariance of factor structure across gender and age, and a pattern of correlations with cognate constructs (e.g., homework completion, academic buoyancy, class participation) consistent with predictions. Notwithstanding the predominantly parallel findings, there was also notable distinctiveness, primarily in terms of mean-level effects, such that elementary school students were generally more motivated and engaged than university/college students who in turn were more motivated and engaged than high school students. Implications for motivation and engagement measurement and theory, research in the psychoeducational domain, and the subsequent potential for performance profiling across the academic life span are discussed.
A longitudinal study of the psycho-social effects of vasectomy.

35 of 48 men studied prior to vasectomy completed follow-up Minnesota Multiphasic Personality Inventories (MMPI) and questionnaires between 1 and 2 years after the operation. The men were referred from private practicing urologists in San Diego County California. They seemed representative of stable productive and successful members of society. 34 of the 35 expressed satisfaction with the contraceptive procedure but 7 reported decreased sexual functioning and MMPI analyses indicated increased psychological disturbance in 15 with only 2 showing some improvement. 8 reported at least 1 positive change in sexual functioning and 21 reported no change at all. Subjects revealing hypochrondrical tendencies preoperatively reacted more adversely to the procedure. The study suggests that subjects may defensively exaggerate postoperative satisfaction. A tentative hypothesis offered is that concern with somatic functioning and even slightly tenuous psychosexual identification may constitute vulnerability to adverse psychological reaction. (AUTHORS MODIFIED)
Differences in free estradiol and sex hormone-binding globulin in women with and without premenstrual dysphoric disorder.

CONTEXT Over the years, different hypotheses involving the ovarian steroid hormones have been proposed to explain the luteal phase occurrence of severe premenstrual syndrome symptoms. Although it had been strongly suspected that differences in the concentrations of the ovarian steroids may underlie the mood and psychological imbalance of this disorder, the evidence for this hypothesis has been inconsistent and remains controversial. OBJECTIVE Our objective was to measure the ovarian steroid hormones across the menstrual cycle in women with and without luteal phase symptoms consistent with premenstrual dysphoric disorder (PMDD). DESIGN We measured estradiol (E2), progesterone, and SHBG in women with and without PMDD using a cross-sectional and prospective experimental design. Participating women underwent 2-month self-assessment symptom screening and 1-month hormonal evaluation. RESULTS Overall means for LH, progesterone, E2, peak E2, and free E2 were not different between groups. Across the menstrual cycle, overall percent free E2 was significantly lower and SHBG significantly greater in the PMDD group compared with controls (1.39 +/- 0.26 vs. 1.50 +/- 0.28, P = 0.03; 61.4 +/- 25.1 vs. 52.4 +/- 21.3 nmol/liter, P = 0.046, respectively). During the luteal phase, free E2 was significantly lower in the PMDD group compared with controls (PMDD 7.6 +/- 7.0 vs. controls 8.9 +/- 8.4 pmol/liter; P = 0.032). For both follicular and luteal phases, SHBG was significantly higher in the PMDD group (follicular phase 60.5 +/- 31.7 vs. 51.4 +/- 38.2 nmol/liter, P = 0.047; luteal phase 65.1 +/- 32.3 vs. 55.1 +/- 38.9 nmol/liter, P =0.03). In both groups, SHBG significantly increased from the follicular to luteal phase. CONCLUSION Luteal phase concentrations of free E2, percent free E2, and SHBG differ significantly between women with and without PMDD.
Flow Disturbances at the Apex and Lateral Angles of a Variety of Bifurcation Models and Their Role in Development and Manifestations of Arterial Disease

Dye flow patterns were studied in 12 glass model bifurcations with angles of 45, 90, 135, and 180°, and area ratios of 0.78,1.03 and 1.27. At the apex, the dye formed a saddle zone, and streamlines from the core which entered this region were swept over the upper and lower surfaces to enter the lateral angles. Qualitatively, the shape and size of the apex played a key role in this effect. Boundary layer separation occurred in the lateral angles, and increased as flow into the branch was reduced. If the branch was occluded, acomplex vortex developed in the first few diameters of the branch, and no flow occurred beyond this, even though the occlusion was about 20 diameters downstream. The results were comparable with steady and pulsatile flow. The implications of these results for the localization of atherosclerosis are discussed.
Modal nonmonotonic logics: ranges, characterization, computation

Many nonmonotonic formalism, including default logic, logic programming with stable models, and autoepistemic logic, can be represented faithfully by means of modal nonmonotonic logics in the family proposed by McDermott and Doyle. In this paper properties of logics in this family are thoroughly investigated. We present several results on characterization of expansions. These results are applicable to a wide class of nonmonotonic modal logics. Using these characterization results, algorithms for computing expansions for finite theories are developed. Perhaps the most important finding of this paper is that the structure of the family of modal nonmonotonic logics is much simpler than that of the family of underlying modal (monotonic) logics. Namely, it is often the case that different monotonic modal logics collapse to the same nonmonotonic system. We exhibit four families of logics whose nonmonotonic variants coincide: 5-KD45, TW5-SW5, N-WK, and W5-D4WB. These nonmonotonic logics naturally represent logics related to commonsense reasoning and knowledge representation such as autoepistemic logic, reflexive autoepistemic logic, default logic, and truth maintenance with negation.
Deep learning neural networks optimization using hardware cost penalty

As deep learning neural networks (DNNs) advance and increase in computational complexity, particularly in terms of memory cost, it becomes difficult to implement DNNs in fixed-point memory-sparse environments (e.g. integrated circuits in consumer electronics). Thus, the training of DNNs must be reformulated to balance the hardware costs needed to represent the often millions of parameter weights in such machine learning models. This paper proposes a novel optimization approach that simultaneously minimizes complexity (total memory) and maximizes accuracy. Specifically, a bit-depth complexity penalty is induced to urge the DNN model towards a state of lower memory using a numerical gradient in optimization iterations. Experimental results on the MNIST (Mixed National Institute of Standards and Technology) handwritten digit classification benchmark demonstrate a minimal loss (1%) in DNN accuracy with a significant reduction (37%) of memory cost on average.
A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Multiple Myeloma Patients Running title : GWAS in multiple myeloma pharmacogenomics

Affiliations 1 INSERM UMR 892, CNRS UMR 6299, Université de Nantes, Nantes, France 2 Centre Hospitalier Universitaire, Nantes, France 3 Erasmus Medical Center, Rotterdam, The Netherlands 4 Centre Hospitalier Universitaire, Toulouse, France 5 Institut de Cancérologie de l’Ouest, Nantes-Saint Herblain, France 6 LIRIS UMR 5205 CNRS Université Claude Bernard Lyon I, Lyon, France. 7 LUNAM Université, IRCCyN, CNRS UMR 6597, Polytech Nantes, France 8 INSERM UMR 1052, CNRS 5286 Centre Léon Bérard, Lyon, France. 9Lebow Institute of Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, DanaFarber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA 10Boston Veterans Administration Healthcare System, West Roxbury, MA, 02132, USA. 11These authors contributed equally to this work. *Correspondence should be addressed to S.M.
Biodistribution, Stability, and Blood Distribution of the Cell Penetrating Peptide Maurocalcine in Mice

Maurocalcine (MCa) is the first natural cell penetrating peptide to be discovered in animal venom. In addition to the fact that it represents a potent vector for the cell penetration of structurally diverse therapeutic compounds, MCa also displays several distinguishing features that make it a potential peptide of choice for clinical and biotechnological applications. The aim of the present study was to gain new information about the properties of MCa in vivo in order to delineate the future potential applications of this vector. For this purpose, two analogues of this peptide with (Tyr-MCa) and without (Lin-Tyr-MCa) disulfide bridges were synthesized, radiolabeled with 125I, and their in vitro stabilities were first evaluated in mouse blood. The results indicated that 125I-Tyr-MCa was stable in vitro and that the disulfide bridges conferred a competitive advantage for the stability of peptide. Following in vivo injection in mice, 125I-Tyr-MCa targeted peripheral organs with interesting quantitative differences and the main route of peptide elimination was renal.
Incidence of Malaria Parasite in Blood Donors at Kwali General Hospital , FCT

Malaria, although preventable and curable, is still one of the most potent killer diseases known to mankind. The disease has successfully been eradicated in some advanced countries, but the disease is still very well around in the developing countries, most especially in the tropical African countries where the climatic conditions favour the development of the vector. Nigeria is endemic for the disease. This research was conducted to determine the incidence of malaria parasite in donated blood at Kwali General Hospital, Abuja. Blood film examination for malaria parasites was carried out for 250 blood donors of which 140 (56%) tested positive to malaria parasite. Information was gotten from respondents on their sex, age and social status. The sample collections span from rainy to dry season between August, 2012 to July, 2013. The sex distribution of the infection, which was not statistically significant in the research showed a higher incidence of malaria infection for males with an incidence of 53.66%. The age of the donors examined ranged between 21 and 65 years. The donors that were between the ages 3140 years had the highest incidence of malaria infection with an incidence of 90.59%. The respondents at the lower class for social status had the highest incidence of 83.33%, out of the three social status classes, and a season distribution with a higher incidence of 81.93% at the rainy season. Based on the result of this research, it is recommended that in a bid to save lives, there is the need for blood banks to include malaria parasite species screening as a routine test of blood from the donors. __________________________________________________________________________________________