Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of a telenovela designed to improve knowledge and behavioral intentions among Hispanic patients with end-stage renal disease in Southern California

Objectives. Culturally relevant education is needed to improve rates of successful kidney transplantation among Hispanic patients with end-stage renal disease (ESRD). This study examined whether patients’ knowledge about kidney disease, postoperative care, and proactive health practices improved after watching a telenovela series about ESRD. Design. 334 ESRD patients and 94 family members/caregivers were assigned to watch a telenovela (‘Fixing Paco,’ a bilingual health education film) or receive standard of care at a transplant center or at a dialysis clinic. Outcomes for pre-transplant patients assigned to standard of care at dialysis centers or at a transplant center were compared to pre-transplant patients in the treatment condition (standard of care + telenovela). Results. Knowledge and behavioral intention scores at baseline across conditions and locations were similar, suggesting that assignment resulted in comparable groups at baseline. Using linear regression, this study found statistically significant improvements in knowledge scores among the telenovela group as compared to the standard of care groups. The telenovela group also had greater improvements in behavioral intention scores compared to the standard of care groups. Family members assigned to the telenovela group had significant improvements in knowledge scores as compared to the standard of care groups. Conclusion. Being well informed about ESRD and adopting proactive health behaviors are important mechanisms in improving transplantation outcomes. These findings suggest that knowledge about kidney disease, postoperative care, and proactive health practices could be improved by viewing a telenovela. Implications, limitations, and directions for future research are discussed.
Approaches to Building Big Data Literacy

Big Data projects are being rapidly embraced by organizations working in the social good sector. This has led to a proliferation of new projects, with strong criticisms in response focusing on the disempowering aspects of these projects. This paper identiﬁes four main problematic aspects of Big Data projects in the social good sector to focus on: lack of transparency , extractive collection , technological complexity , and control of impact . Leveraging Paulo Freire’s concept of "Popular Education", we identify an opportunity to work on these issues in empowering ways through literacy education. We discuss existing deﬁnitions of data literacy and ﬁnd a need to create an extended deﬁnition of Big Data literacy. Surveying existing approaches to building data literacy, we identify the need for new approaches and technologies to address the problematic aspects of Big Data projects. To ﬂesh out this concept of "Popular Big Data", we close by oﬀer-ing seven ideas for how the ﬁeld can ensure that Big Data projects are in line with the values of organizations working in the social good sector.
Deep silicon maxima in the stratified oligotrophic Mediterranean Sea

Abstract. The silicon biogeochemical cycle has been studied in the Mediterranean Sea during late summer/early autumn 1999 and summer 2008. The distribution of nutrients, particulate carbon and silicon, fucoxanthin (Fuco), and total chlorophyll-a (TChl-a) were investigated along an eastward gradient of oligotrophy during two cruises (PROSOPE and BOUM) encompassing the entire Mediterranean Sea during the stratified period. At both seasons, surface waters were depleted in nutrients and the nutriclines gradually deepened towards the East, the phosphacline being the deepest in the easternmost Levantine basin. Following the nutriclines, parallel deep maxima of biogenic silica (DSM), fucoxanthin (DFM) and TChl-a (DCM) were evidenced during both seasons with maximal concentrations of 0.45 μmol L−1 for BSi, 0.26 μg L−1 for Fuco, and 1.70 μg L−1 for TChl-a, all measured during summer. Contrary to the DCM which was a persistent feature in the Mediterranean Sea, the DSM and DFMs were observed in discrete areas of the Alboran Sea, the Algero-Provencal basin, the Ionian sea and the Levantine basin, indicating that diatoms were able to grow at depth and dominate the DCM under specific conditions. Diatom assemblages were dominated by Chaetoceros spp. , Leptocylindrus spp. , Pseudonitzschia spp. and the association between large centric diatoms (Hemiaulus hauckii and Rhizosolenia styliformis) and the cyanobacterium Richelia intracellularis was observed at nearly all sites. The diatom's ability to grow at depth is commonly observed in other oligotrophic regions and could play a major role in ecosystem productivity and carbon export to depth. Contrary to the common view that Si and siliceous phytoplankton are not major components of the Mediterranean biogeochemistry, we suggest here that diatoms, by persisting at depth during the stratified period, could contribute to a large part of the marine primary production as observed in other oligotrophic areas.
Covariate matching methods for testing and quantifying wind turbine upgrades

In the wind industry, engineers perform retrofitting upgrades on inservice wind turbines for the purpose of improving power production capabilities. Considering how costly an upgrade can be, people often wonder about the upgrade effect: whether it indeed improves turbine performances, and if so, how much. One cannot simply compare power outputs for the purpose of assessing a turbine’s improvement, as wind power generation is affected by an array of environmental covariates, including wind speed, wind direction, temperature, pressure as well as other atmosphere dynamics. For a fair comparison to discern the upgrade effect, it is critical to have these environmental effects controlled for while comparing power output differences. Most existing approaches rely on establishing a power curve model and let the model account for the environmental effects. In this paper, we propose a different approach, which is to devise a covariate matching method to ensure the environmental covariates to have comparable distribution profiles before and after an action of upgrade. Once the covariates are matched, paired t-tests can be applied to the power outputs for testing the significance of the upgrade effect. The relative increase in power production can also be quantified. The proposed approach is simple to use and relies on fewer assumptions than the power curve modeling approach.
Monitoring reservoir response to earthquakes and fluid extraction, Salton Sea geothermal field, California

Seismic interferometry provides insights into in situ reservoir response to stress changes. Continuous monitoring of in situ reservoir responses to stress transients provides insights into the evolution of geothermal reservoirs. By exploiting the stress dependence of seismic velocity changes, we investigate the temporal evolution of the reservoir stress state of the Salton Sea geothermal field (SSGF), California. We find that the SSGF experienced a number of sudden velocity reductions (~0.035 to 0.25%) that are most likely caused by openings of fractures due to dynamic stress transients (as small as 0.08 MPa and up to 0.45 MPa) from local and regional earthquakes. Depths of velocity changes are estimated to be about 0.5 to 1.5 km, similar to the depths of the injection and production wells. We derive an empirical in situ stress sensitivity of seismic velocity changes by relating velocity changes to dynamic stresses. We also observe systematic velocity reductions (0.04 to 0.05%) during earthquake swarms in mid-November 2009 and late-December 2010. On the basis of volumetric static and dynamic stress changes, the expected velocity reductions from the largest earthquakes with magnitude ranging from 3 to 4 in these swarms are less than 0.02%, which suggests that these earthquakes are likely not responsible for the velocity changes observed during the swarms. Instead, we argue that velocity reductions may have been induced by poroelastic opening of fractures due to aseismic deformation. We also observe a long-term velocity increase (~0.04%/year) that is most likely due to poroelastic contraction caused by the geothermal production. Our observations demonstrate that seismic interferometry provides insights into in situ reservoir response to stress changes.
Being Committed

Few studies have examined adolescents’ understanding of romantic relationship commitment, particularly among African American youth. Using three waves of semistructured interviews, the present descriptive study addresses this topic by exploring the ways in which 20 African American adolescents (age range 13-19 years) from low-income backgrounds conceptualize and describe commitment in romantic relationships. Qualitative analyses revealed three main themes related to defining commitment, indicating that which commitment provides, and describing the nature of commitment in different relationship contexts. Findings inform psychological research and practice relating to commitment and romantic relationships among African American adolescents.
How transformational leadership facilitates e-business adoption

The purpose of this paper is to examine theoretically and empirically what type of leadership facilitates e-business adoption in large manufacturing firms. The digital transformation of firms requires leadership that can promote the adaptive quality of organizational culture. ,The authors conducted an empirical study using two key informants from a sample of 181 incumbent firms. ,The authors find significant evidence that adaptive culture is the vehicle by which transformational leaders positively influence e-business adoption. ,Given the digital economy’s external pressures, many e-business adoption processes fail due to organizational factors originating in leadership and its capability to change followers’ values, norms, and motivations. To solve this problem, the authors propose a model that explains how transformational leadership first plays a key role in changing characteristics of culture and then facilitates e-business adoption.
Millimeter Wave and Drug Induced Modulation of the Immune System -Application in Cancer Immunotherapy

In recent years several approaches have been used for the treatment of cancer. These include surgery, chemotherapy, radiotherapy, and immunotherapy. Immunotherapy includes systemic administration of cytokines, adaptive transfer of activated T cells, NK cells, dendritic cells and macrophages. Immunotherapy is used to stimulate and train the patient’s immune system to fight against cancer. However, this approach alone is not sufficient. Therefore, a combination of immunotherapy with conventional chemo- and radiation therapy is commonly used for the treatment of cancer. But systemic administration of cytokines, such as interferons and interleukins, commonly used for immunotherapy, have their own toxic side effects that can be life threatening to many patients. In this article, we have reviewed the current knowledge of the effects of millimeter wave therapy (MMWT) on the immune system. MMWT, an alternative and complementary modality of treatment, is widely used for the treatment of cancer and many other diseases in Russia and several East European countries. However, it is virtually unknown to Western physicians. Our experimental studies have shown that MMWT when used in combination with chemotherapy protects the immune system from the toxicity of chemotherapy without introducing any additional toxicity of its own. Furthermore, our studies have shown that the combined millimeter wave- and chemotherapy can reduce the tumor metastasis, and tumor resistance to chemotherapeutic drugs. Thus combined therapy using MMWT provides a promising new strategy for the treatment of cancer.
The Style of Tetris is...Possibly Tetris?: Creative Professionals' Description of Video Game Visual Styles

Despite the increasing importance of video games in both cultural and commercial aspects, typically they can only be accessed and browsed through limited metadata such as platform or genre. We explore visual styles of games as a complementary approach for providing access to games. In particular, we aimed to test and evaluate the existing visual style taxonomy developed in prior research with video game professionals and creatives. User data were collected from video game art and design students at the DigiPen Institute of Technology to gain insight into the relevance of the existing taxonomy to a professional audience. Using a think-aloud card sort method, we observed their thought process for describing and categorizing visual styles of video games, and also collected candidate terms for revising the taxonomy. The results of this research will inform ongoing metadata work in the field to develop a standard for cataloging video games and interactive media, and will be useful to information systems that sort and classify games for users and cultural preservation.
[Three-dimensional analysis of the regional contractility of the normal and the cardiomyopathic left ventricle using cine-magnetic resonance imaging].

The left ventricular regional contractile pattern, global function and mass of normal subjects and patients with idiopathic dilated cardiomyopathy was compared using cine magnetic resonance imaging (MRI) in a short-axis imaging plane. Left ventricular ejection fraction and mass were 64.3 +/- 2.5% and 115 +/- 10 g in normal hearts and 23.5 +/- 3.1% and 194 +/- 20 g in dilated cardiomyopathic hearts (p less than 0.001 and p less than 0.002). Left ventricular end-diastolic wall thickness was homogeneous in normal hearts except for the posterior wall at the basal level, which was significantly thinner compared to the anterolateral wall and the septum (p less than 0.02). End-diastolic wall thickness in the cardiomyopathic group was significantly more heterogeneous and was thinner at the apical compared to the basal level (p less than 0.02) as well as in the segment of the posterior compared to the anterolateral and septal wall (p less than 0.005 and p less than 0.03). In normal hearts, left ventricular end-systolic wall thickness was progressively greater from base to apex for the anterolateral (p less than 0.01) and posterior wall (p less than 0.02) and the septum (p less than 0.02). Such a uniform gradient of end-systolic wall thickness was not present in hearts with dilated cardiomyopathy. It was even reversed for the anterolateral wall with decreasing thickness from base to apex (p less than 0.03). Left ventricular mean systolic wall thickening increased progressively from base to apex (p less than 0.005) in normal hearts, whereas there was no significant gradient from base to apex in hearts with dilated cardiomyopathy. (ABSTRACT TRUNCATED AT 250 WORDS)
Gene Expression Profiling of Solitary Fibrous Tumors

Background Solitary fibrous tumors (SFTs) are rare spindle-cell tumors. Their cell-of-origin and molecular basis are poorly known. They raise several clinical problems. Differential diagnosis may be difficult, prognosis is poorly apprehended by histoclinical features, and no effective therapy exists for advanced stages. Methods We profiled 16 SFT samples using whole-genome DNA microarrays and analyzed their expression profiles with publicly available profiles of 36 additional SFTs and 212 soft tissue sarcomas (STSs). Immunohistochemistry was applied to validate the expression of some discriminating genes. Results SFTs displayed whole-genome expression profiles more homogeneous and different from STSs, but closer to genetically-simple than genetically-complex STSs. The SFTs/STSs comparison identified a high percentage (∼30%) of genes as differentially expressed, most of them without any DNA copy number alteration. One of the genes most overexpressed in SFTs encoded the ALDH1 stem cell marker. Several upregulated genes and associated ontologies were also related to progenitor/stem cells. SFTs also overexpressed genes encoding therapeutic targets such as kinases (EGFR, ERBB2, FGFR1, JAK2), histone deacetylases, or retinoic acid receptors. Their overexpression was found in all SFTs, regardless the anatomical location. Finally, we identified a 31-gene signature associated with the mitotic count, containing many genes related to cell cycle/mitosis, including AURKA. Conclusion We established a robust repertoire of genes differentially expressed in SFTs. Certain overexpressed genes could provide new diagnostic (ALDH1A1), prognostic (AURKA) and/or therapeutic targets.
Detection of a lipid peroxidation-induced DNA adduct across liver disease stages.

Background Oxidative stress and chronic inflammation can increase cellular levels of reactive oxygen species and lipid peroxidation (LPO) when associated with the pathogenesis of hepatocellular carcinoma (HCC), which can develop following the progression of steatosis, fibrosis and cirrhosis. Using a monoclonal antibody for cyclic γ-hydroxy-1, N2 -propanodeoxyguanosine (γ-OHPdG), a promutagenic DNA adduct formed endogenously by LPO, we examined its formation across liver disease stages to understand it's potential role in HCC development. Methods Formalin-fixed paraffin embedded (FFPE) liver tissue samples from 49 patients representing normal, steatosis, fibrosis, cirrhosis and HCC were stained for γ-OHPdG and 8-hydroxydeoxyguanosine (8-oxo-dG), an oxidative damage biomarker. Quantification of immunohistochemical (IHC) staining was performed using histological scoring of intensity and distribution. Using primary human hepatocytes (HH) and a stellate cell (SC) co-culture, immunocytochemical staining of γ-OHPdG and Nile Red was performed to determine if the formation of γ-OHPdG was consistent between the clinical sample disease stages and the in vitro steatotic and fibrotic conditions. Results γ-OHPdG levels varied significantly between the stages of normal and steatosis, steatosis and fibrosis, and steatosis and cirrhosis (P≤0.005). There was a trend, although not significant, of increased levels of γ-OHPdG in HCC compared to the other groups. A strong correlation was observed (Pearson's, R2 =0.85) between levels of γ-OHPdG and 8-oxo-dG across the disease spectrum. The increase of γ-OHPdG in steatosis and decrease in fibrosis was a pattern confirmed in an in vitro model using primary HH co-cultured with human SCs. Conclusions γ-OHPdG was detected in FFPE liver tissues of patients with different stages of liver disease and in vitro studies, demonstrating that its formation is consistent with LPO in early stages of liver disease and suggesting that it may be a source of mutagenic DNA damage in liver disease progression.
Independent Prognostic Value of Serum Soluble ST2 Measurements in Patients With Heart Failure and a Reduced Ejection Fraction in the PARADIGM-HF Trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure)

Background: Soluble ST2 (sST2) is associated with cardiac remodeling and fibrosis. In chronic heart failure, the predictive value of sST2 has not been evaluated in a model that includes both NT-proBNP (N-terminal pro-B-type natriuretic peptide) and hs-TnT (high-sensitivity cardiac troponin T), in a trial in which treatment had a major impact. Therefore, the effects of treatment on sST2 levels in PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the relationships between sST2 and outcomes, and the prognostic utility of various sST2 partition values were examined. Methods and Results: Baseline (n=2002), 1-month (n=1936), and 8-month postrandomization (n=1758) sST2 levels were compared between treatment groups (sacubitril/valsartan versus enalapril). Relationships between baseline sST2 and (1) heart failure hospitalization, (2) cardiovascular death, and (3) combined heart failure hospitalization and cardiovascular death were assessed using restricted cubic spline models. Adjusted Cox proportional hazards models were used to examine the impact of sST2 change from baseline to 1 month on the hazard of experiencing each outcome. Sacubitril/valsartan led to more reductions and fewer increases in sST2 levels versus enalapril. After adjusting for other predictors, including NT-proBNP and hs-TnT, baseline sST2 remained an independent predictor of outcomes. Associations between baseline sST2 and outcomes were linear. sST2 increases at 1 month were associated with worse subsequent outcomes and decreased with better outcomes (P=0.001, 0.012, and 0.009 for the 3 outcomes, respectively). Conclusions: Sacubitril/valsartan resulted in greater reductions and less increases in sST2 levels than enalapril. No specific threshold was associated with risk, as linear relationships between baseline sST2 and outcomes were observed. Changes in sST2 from baseline to 1 month were independently associated with the risk of outcomes. Clinical Trial Registration : URL: https://www.clinicaltrials. gov. Unique identifier: NCT01035255.
A Comparison of Evolutionary Programming and Genetic Algorithms on Selected Constrained Optimization Problems

Evolutionary programming and genetic algorithms are compared on two constrained optimization problems. The constrained problems are redesigned as related unconstrained problems by the application of penalty functions. The experiments indicate that evolutionary programming outperforms the genetic algorithm. The results are statistically significant under nonparametric hypothesis testing. The results also indicate potential difficulties in the design of suitable penalty functions for constrained optimization problems. A discussion is offered regarding the suitability of different methods of evolutionary computation for such problems.
INTERPERSONAL RELATIONS AND GROUP PROCESSES Interpersonal Emotion Regulation: Implications for Affiliation, Perceived Support, Relationships, and Well-Being

People often recruit social resources to manage their emotions, a phenomenon known as interpersonal emotion regulation (IER). Despite its importance, IER’s psychological structure remains poorly understood. We propose that two key dimensions describe IER: (a) individuals’ tendency to pursue IER in response to emotional events, and (b) the efficacy with which they perceive IER improves their emotional lives. To probe these dimensions, we developed the Interpersonal Regulation Questionnaire (IRQ), a valid and reliable measure of individual differences in IER. Factor analyses of participants’ responses confirmed tendency and efficacy as independent dimensions of IER (Study 1; N (cid:2) 285), and demonstrated independence between how individuals engage with IER in response to negative, versus positive, emotion. In Study 2 ( N (cid:2) 347), we found that individuals high in IER tendency and efficacy are more emotionally expressive, empathetic, and socially connected. Two subsequent studies highlighted behavioral consequences of IER dimensions: people high in IER tendency sought out others more often following experimentally induced emotion (Study 3; N (cid:2) 400), and individuals high in IER efficacy benefitted more from social support after real-world emotional events (Study 4; N (cid:2) 787). Finally, a field study of social networks in freshman dormitories revealed that individuals high in IER tendency and efficacy developed more supportive relationships during the first year of college (Study 5; N (cid:2) 193). These data (a) identify distinct dimensions underlying IER, (b) demonstrate that these dimensions can be stably measured and separated from related constructs, and (c) reveal their implications for relationships and well-being.