Miracle-dz/UniFAR-FTUs huggingface dataset:
The Oenological Potential of Hanseniaspora uvarum in Simultaneous and Sequential Co-fermentation with Saccharomyces cerevisiae for Industrial Wine Production

In oenology, the utilization of mixed starter cultures composed by Saccharomyces and non-Saccharomyces yeasts is an approach of growing importance for winemakers in order to enhance sensory quality and complexity of the final product without compromising the general quality and safety of the oenological products. In fact, several non-Saccharomyces yeasts are already commercialized as oenological starter cultures to be used in combination with Saccharomyces cerevisiae, while several others are the subject of various studies to evaluate their application. Our aim, in this study was to assess, for the first time, the oenological potential of H. uvarum in mixed cultures (co-inoculation) and sequential inoculation with S. cerevisiae for industrial wine production. Three previously characterized H. uvarum strains were separately used as multi-starter together with an autochthonous S. cerevisiae starter culture in lab-scale micro-vinification trials. On the basis of microbial development, fermentation kinetics and secondary compounds formation, the strain H. uvarum ITEM8795 was further selected and it was co- and sequentially inoculated, jointly with the S. cerevisiae starter, in a pilot scale wine production. The fermentation course and the quality of final product indicated that the co-inoculation was the better performing modality of inoculum. The above results were finally validated by performing an industrial scale vinification The mixed starter was able to successfully dominate the different stages of the fermentation process and the H. uvarum strain ITEM8795 contributed to increasing the wine organoleptic quality and to simultaneously reduce the volatile acidity. At the best of our knowledge, the present report is the first study regarding the utilization of a selected H. uvarum strain in multi-starter inoculation with S. cerevisiae for the industrial production of a wine. In addition, we demonstrated, at an industrial scale, the importance of non-Saccharomyces in the design of tailored starter cultures for typical wines.
Towards Practical Graph-Based Verification for an Object-Oriented Concurrency Model

To harness the power of multi-core and distributed platforms, and to make the development of concurrent software more accessible to software engineers, different object-oriented concurrency models such as SCOOP have been proposed. Despite the practical importance of analysing SCOOP programs, there are currently no general verification approaches that operate directly on program code without additional annotations. One reason for this is the multitude of partially conflicting semantic formalisations for SCOOP (either in theory or by-implementation). Here, we propose a simple graph transformation system (GTS) based run-time semantics for SCOOP that grasps the most common features of all known semantics of the language. This run-time model is implemented in the state-of-the-art GTS tool GROOVE, which allows us to simulate, analyse, and verify a subset of SCOOP programs with respect to deadlocks and other behavioural properties. Besides proposing the first approach to verify SCOOP programs by automatic translation to GTS, we also highlight our experiences of applying GTS (and especially GROOVE) for specifying semantics in the form of a run-time model, which should be transferable to GTS models for other concurrent languages and libraries.
Revision of the boselaphin bovid Miotragocerus monacensis STROMER, 1928 (Mammalia, Bovidae) at the Middle to Late Miocene transition in Central Europe

During excavations in 2011-2014, new fossil material of the boselaphin Miotragocerus monacensis Stromer, 1928 (Mammalia, Bovidae) was found at the locality Hammerschmiede (Bavaria, Germany), which is dated to ~11.6 Ma (Middle to Late Miocene transition). For the first time, both dentition and postcranial material can be studied on this species. These new findings complete a collection of casts stored in the Bavarian State Collection for Palaeontology and Geology. In addition, the holotype of M. monacensis from Oberföhring (Bavaria, Germany) and further unpublished material from Southern Germany and Lower Austria are newly described in this study. Important new taxonomic characters are emphasized improving our knowledge on the species which was originally described based on one single horn core. M. monacensis can be assigned to the basal Boselaphini based on the plesiomorphic features in the dentition and characters of the postcranial material. Intraspecific variabilities, ontogenetic changes and allometries are identified improving the differenciation to other basal boselaphins like Miotragocerus pannoniae, Austroportax latifrons and Protagocerus chantrei. An improved statement regarding the biostratigraphic range of basal Boselaphines from Central Europe is provided.
The Thylakoid FtsH Protease Plays a Role in the Light-Induced Turnover of the Photosystem II D1 Protein

The photosystem II reaction center D1 protein is known to turn over frequently. This protein is prone to irreversible damage caused by reactive oxygen species that are formed in the light; the damaged, nonfunctional D1 protein is degraded and replaced by a new copy. However, the proteases responsible for D1 protein degradation remain unknown. In this study, we investigate the possible role of the FtsH protease, an ATP-dependent zinc metalloprotease, during this process. The primary light-induced cleavage product of the D1 protein, a 23-kD fragment, was found to be degraded in isolated thylakoids in the dark during a process dependent on ATP hydrolysis and divalent metal ions, suggesting the involvement of FtsH. Purified FtsH degraded the 23-kD D1 fragment present in isolated photosystem II core complexes, as well as that in thylakoid membranes depleted of endogenous FtsH. In this study, we definitively identify the chloroplast protease acting on the D1 protein during its light-induced turnover. Unlike previously identified membrane-bound substrates for FtsH in bacteria and mitochondria, the 23-kD D1 fragment represents a novel class of FtsH substrate— functionally assembled proteins that have undergone irreversible photooxidative damage and cleavage.
Methods for epidemiological study of injuries to professional football players: developing the UEFA model

A problem with epidemiological studies of football injuries is the inconsistent manner in which injury is defined and data are collected. Projects have been initiated to study the incidence and causes of injury in football, but there is no uniformly accepted reporting system. In this report, some common pitfalls encountered in the recording of injury are addressed, and practical guidelines for epidemiological studies are provided. An injury reporting system developed for the UEFA Football Safety Project for studies on professional footballers is used as a starting point for a general discussion on injury registration and compared with other existing reporting systems. The recording definition of injury may vary between studies depending on its purpose. A time loss injury definition is practical for all playing levels, and, as a minimum, results on time loss injuries should therefore always be reported separately to allow direct comparisons between studies. There is a need to agree on a uniform sports injury classification system with corresponding diagnostic criteria, as well as standardised return to play criteria after injury.
Magnetic and electric black holes in arbitrary dimensions

In this work, we compare two different objects: electric black holes and magnetic black holes in arbitrary dimension. The comparison is made in terms of the corresponding moduli space and their extremal geometries. We treat parallelly the magnetic and the electric cases. Specifically, we discuss the gravitational solution of these spherically symmetric objects in the presence of a positive cosmological constant. Then, we find the bounded region of the moduli space allowing the existence of black holes. After identifying it in both the electric and the magnetic case, we calculate the geometry that comes out between the horizons at the coalescence points. Although the electric and magnetic cases are both very different (only dual in four dimensions), gravity solutions seem to clear up most of the differences and lead to very similar geometries.
AzTEC millimetre survey of the COSMOS field – III. Source catalogue over 0.72 deg2 and plausible boosting by large-scale structure

We present a 0.72 deg^2 contiguous 1.1-mm survey in the central area of the Cosmological Evolution Survey field carried out to a 1σ ≈ 1.26 mJy beam^(−1) depth with the AzTEC camera mounted on the 10-m Atacama Submillimeter Telescope Experiment. We have uncovered 189 candidate sources at a signal-to-noise ratio (S/N) ≥ 3.5, out of which 129, with S/N ≥ 4, can be considered to have little chance of being spurious (≲ 2 per cent). We present the number counts derived with this survey, which show a significant excess of sources when compared to the number counts derived from the ~0.5 deg^2 area sampled at similar depths in the Submillimetre Common-User Bolometer Array (SCUBA) HAlf Degree Extragalactic Survey (SHADES). They are, however, consistent with those derived from fields that were considered too small to characterize the overall blank-field population. We identify differences to be more significant in the S_(1.1mm) ≳ 5 mJy regime, and demonstrate that these excesses in number counts are related to the areas where galaxies at redshifts z ≲ 1.1 are more densely clustered. The positions of optical–infrared galaxies in the redshift interval 0.6 ≲ z ≲ 0.75 are the ones that show the strongest correlation with the positions of the 1.1-mm bright population (S_(1.1mm) ≳ 5 mJy), a result which does not depend exclusively on the presence of rich clusters within the survey sampled area. The most likely explanation for the observed excess in number counts at 1.1-mm is galaxy–galaxy and galaxy–group lensing at moderate amplification levels, which increases in amplitude as one samples larger and larger flux densities. This effect should also be detectable in other high-redshift populations.
Effect of drying methods on the phenolic content and antioxidant capacity of Brazilian winemaking byproducts and their stability over storage

Abstract This work aimed to study the antioxidant capacity by different methods, the total content of polyphenols and the stability over time of dried byproducts from Brazilian hybrids and Vitis vinifera varieties. Oven-dried at 50 °C and spray-dried samples were monitored for 90 days of storage. Under testing conditions, BRS Violeta grapes showed the greatest stability and initial high levels of total phenolics and anthocyanins remained almost unchanged until the end of storage period. The same behavior was observed in BRS Violeta freeze-dried skins, seeds and lees (8557, 9520 and 4261 mg GAE/100 g DM, respectively, and 829 and 257 mg mv-3-glc/100 g DM in skin and lees, respectively). In all methodologies tested, BRS Violeta also showed higher values for antioxidant capacity. These results suggest that dried winemaking byproducts can be used as rich sources of polyphenol compounds for industrial extractions with high stability and antioxidant capacity.
Fixed-Dose Rasburicase in Overweight and Obese Patients Versus Normal-Weight Patients

Background: Fixed-dose rasburicase (FDR) is common practice in treating hyperuricemia associated with tumor lysis syndrome in adults; however, there is a lack of data regarding the effectiveness of this dosing strategy specifically in the overweight and obese patient populations. Objective: To determine if patient weight per body mass index (BMI) category is associated with failure of initial FDR as defined by the need for additional dose(s) based on a uric acid level (UAL) ≥7.5 mg/dL within 10 days of previous rasburicase administration. Method: Adults who received FDR per institutional guidelines from October 2008 to August 2013 were reviewed. Patients had either a baseline UAL ≥7.5 mg/dL or were considered high risk (leukemia or lymphoma diagnosis with white blood cell count >50 000/mm3 or lactate dehydrogenase level greater than 2 times the upper limit of normal). Patients were stratified by BMI as underweight (<18.5), normal (18.5-24.9), overweight (25-29.9), or obese (30+). Result: Overall, 12 out of 151 patients who received FDR required a repeat dose of rasburicase. The percentage of patients requiring a repeat rasburicase dose was not different between obese/overweight versus normal/underweight patients (8.7% vs 6.4%, P = 0.75). Similarly, there was no difference between obese alone versus normal/underweight patients (12.3% vs 6.4%; P = 0.51). Conclusion: In this retrospective analysis, patient BMI did not correlate with failure of FDR in adults, suggesting that this dosing strategy is efficacious in the adult population.
Rate Allocation and Admission Control for Differentiated Services in CDMA Data Networks

In this paper, we propose a unified framework for rate allocation and admission control for CDMA data networks with a goal of maximizing the service provider's revenue taking into consideration user churn behavior, i.e., users' migration from one provider to another. The power constrained discrete rate allocation (PC-DRA) problem that finds the rates at which the base station must transmit to each user is very difficult because of the nonlinear nature of the objective function, the discrete nature of available rates, and the complex relationship between data rate, the target SINR, and the total power constraint. We prove that the PC-DRA problem is NP-complete for CDMA data networks and then propose three heuristics - a two step selective rate reduction (SRR) scheme, a genetic algorithm (GA), and an improved genetic algorithm (IGA) to solve it. We show that all three heuristics can achieve suboptimal that is very close to the global optimal, while SRR provides solutions of high quality with much less computation time than GA and IGA. At the frame level, the rate allocation maximizes the service provider's revenue by adjusting individual user's data rate on a frame by frame basis. On the other hand, the service provider's revenue varies with the system load, which is decided by admission control at the session level. Thus, the admission control needs to maintain an optimal system load. An efficient resource management framework is provided by the cross level (layer) interaction between the link layer (rate control) and the network layer (admission control) in the sense that 1) they share the same objective of maximizing the service provider's revenue, and 2) the solution to the rate allocation problem provides critical information for the admission control decision. The proposed framework is evaluated by extensive simulation experiments with realistic Web browsing and FTP traffic models. Simulation results confirm that the framework is able to provide class-based differentiated data services that also maximize the service provider's revenue
A MicroRNA Signature in Pediatric Ulcerative Colitis: Deregulation of the miR-4284/CXCL5 Pathway in the Intestinal Epithelium

Background:Twenty to 25% of the patients with inflammatory bowel disease (IBD) present the disease before the age of 18 to 20, with worse extent and severity, compared with adult-onset IBD. We sought to identify the differential expression of microRNAs in pediatric ulcerative colitis (UC) and their association with different clinical phenotypes. Methods:MicroRNA expression analysis was performed in colonic tissues derived from pediatric patients with UC and controls without IBD. MiR-4284 levels were verified by real-time quantitative polymerase chain reaction in 2 additional cohorts of pediatric patients with UC. Bioinformatics analysis was performed to predict the targets of miR-4284. In vitro experiments using luciferase reporter assays and real-time polymerase chain reaction evaluated the direct effect of miR-4284 on CXCL5 mRNA. In vivo experiments were performed in 2 mouse models of experimental colitis. Results:A 24-microRNA signature was identified in colonic tissues derived from pediatric patients with UC. The most downregulated microRNA in the tissue of pediatric patients UC, relative to non-IBD controls, was miR-4284. In situ hybridization revealed that miR-4284 is present in colonic epithelial cells, and its levels correlate with the disease activity. Furthermore, we found that miR-4284 regulates CXCL5 mRNA expression through binding to its 3′UTR. CXCL5 had increased mRNA levels in colonic tissue from pediatric patients with UC and correlated with disease activity. Furthermore, we found an inverse correlation between miR-4284 and CXCL5 levels in the colonic pediatric UC tissues and in 2 mouse models of experimental colitis. Conclusions:Our data reveal a novel microRNA pediatric UC signature and provide evidence that miR-4284 directly regulates CXCL5 and correlates with the disease activity.
SkipFlow: Incorporating Neural Coherence Features for End-to-End Automatic Text Scoring

Deep learning has demonstrated tremendous potential for Automatic Text Scoring (ATS) tasks. In this paper, we describe a new neural architecture that enhances vanilla neural network models with auxiliary neural coherence features. Our new method proposes a new SkipFlow mechanism that models relationships between snapshots of the hidden representations of a long short-term memory (LSTM) network as it reads. Subsequently, the semantic relationships between multiple snapshots are used as auxiliary features for prediction. This has two main benefits. Firstly, essays are typically long sequences and therefore the memorization capability of the LSTM network may be insufficient. Implicit access to multiple snapshots can alleviate this problem by acting as a protection against vanishing gradients. The parameters of the SkipFlow mechanism also acts as an auxiliary memory. Secondly, modeling relationships between multiple positions allows our model to learn features that represent and approximate textual coherence. In our model, we call this neural coherence features. Overall, we present a unified deep learning architecture that generates neural coherence features as it reads in an end-to-end fashion. Our approach demonstrates state-of-the-art performance on the benchmark ASAP dataset, outperforming not only feature engineering baselines but also other deep learning models.
Acoustic Micro-Doppler Gait Signatures of Humans and Animals

A micro-Doppler active acoustic sensing system is described. We report its use in acquiring gait signatures of humans and four-legged animals in indoor and outdoor environments. Signals from an accelerometer attached to the leg support the interpretation of the components in the measured micro-Doppler signature. The acoustic micro-Doppler system described in this paper is simpler and offers advantages over the widely used electromagnetic wave micro-Doppler radars. It can be implemented in custom integrated circuits and embedded in a multi-modal wireless sensor network for autonomous detection and classification.
Fano Hypersurfaces in Weighted Projective 4-Spaces

We determine the full list of anticanonically embedded quasismooth Fano hypersurfaces in weighted projective 4-spaces. There are 48 infinite series and 4442 sporadic examples. In particular, the Reid-Fletcher list of 95 types of anticanonically embedded quasismooth terminal Fano threefolds in weighted projective 4-spaces is complete. We also prove that many of these Fano hypersurfaces admit a Kähler-Einstein metric, and study the nonexistence of tigers on these Fano 3-folds. Finally, we prove that there are only finitely many families of quasismooth Calabi-Yau hypersurfaces in weighted projective spaces of any given dimension. This implies finiteness for various families of general type hypersurfaces.
Sleep and Aging: Examining the Effect of Psychological Symptoms and Risk of Sleep-Disordered Breathing

Controversy exists as to whether self-reported sleep quality declines with age, despite changes in sleep being accepted as part of normal aging. This study sought to investigate age-related differences in self-reported sleep quality, after controlling for conditions that are common with age, such as psychological symptoms and increased risk of sleep-disordered breathing (SDB). The Pittsburgh Sleep Quality Index (PSQI) was administered to a sample of 582 community adults (aged 18–89 years), and the association between age and 3 factors of the PSQI (sleep efficiency, perceived sleep quality, and daily disturbance), and global scores, was examined controlling for depression, anxiety, stress, gender, and SDB risk. Results indicate that (a) before controlling for covariates, there was no significant relation between age and all indexes of self-reported sleep quality, with the exception of sleep efficiency. However, once depression, gender, and SDB risk were controlled for, a significant, yet small, relation was revealed between older age and poorer global sleep quality; (b) there was no association between age and perceived sleep quality or daily disturbances before or after controlling for relevant covariates; and (c) depression, gender, and SDB risk were significant predictors of poorer sleep quality across the indexes but, in general, did not have a marked impact on the relation between age and sleep quality. In conclusion, results suggest that sleep problems are common across the lifespan, and that there were modest age-related differences in self-reported sleep quality, which were not due to depressed mood, gender, or risk of SDB.
DDD17: End-To-End DAVIS Driving Dataset

Event cameras, such as dynamic vision sensors (DVS), and dynamic and active-pixel vision sensors (DAVIS) can supplement other autonomous driving sensors by providing a concurrent stream of standard active pixel sensor (APS) images and DVS temporal contrast events. The APS stream is a sequence of standard grayscale global-shutter image sensor frames. The DVS events represent brightness changes occurring at a particular moment, with a jitter of about a millisecond under most lighting conditions. They have a dynamic range of >120 dB and effective frame rates >1 kHz at data rates comparable to 30 fps (frames/second) image sensors. To overcome some of the limitations of current image acquisition technology, we investigate in this work the use of the combined DVS and APS streams in end-to-end driving applications. The dataset DDD17 accompanying this paper is the first open dataset of annotated DAVIS driving recordings. DDD17 has over 12 h of a 346x260 pixel DAVIS sensor recording highway and city driving in daytime, evening, night, dry and wet weather conditions, along with vehicle speed, GPS position, driver steering, throttle, and brake captured from the car's on-board diagnostics interface. As an example application, we performed a preliminary end-to-end learning study of using a convolutional neural network that is trained to predict the instantaneous steering angle from DVS and APS visual data.