Miracle-dz/UniFAR-FTUs huggingface dataset:
A Quantitative Analysis of Disk Drive Power Management in Portable Computers

With the advent and subsequent popularity of portable computers, power management of system components has become an important issue. Current portable computers implement a number of power reduction techniques to achieve a longer battery life. Included among these is spinning down a disk during long periods of inactivity. In this paper, we perform a quantitative analysis of the potential costs and benefits of spinning down the disk drive as a power reduction technique. Our conclusion is that almost all the energy consumed by a disk drive can be eliminated with little loss in performance. Although on current hardware, reliability can be impacted by our policies, the next generation of disk drives will use technology (such as dynamic head loading) which is virtually unaffected by repeated spinups. We found that the optimal spindown delay time, the amount of time the disk idles before it is spun down, is 2 seconds. This differs significantly from the 3-5 minutes in current practice by industry. We will show in this paper the effect of varying the spindown delay on power consumption; one conclusion is that a 3-5 minute delay results in only half of the potential benefit of spinning down a disk.
Emotional processing in bipolar disorder: Behavioural and neuroimaging findings

Existing studies revealed that bipolar patients show an altered identification of emotional stimuli (e.g. facial expressions), however, so far modifications in early emotional processes and the regulation of emotions are less clear. In response to emotional stimuli bipolar patients show a dysfunction in a ventral-limbic brain network including the amygdala, insula, striatum, subgenual cingulate cortex, ventrolateral prefrontal cortex and orbitofrontal cortex. In most studies, a relative hypoactivity of dorsal brain structures, including the dorsolateral prefrontal cortex, the dorsal anterior cingulate and the posterior cingulate cortex, has been reported in bipolar patients. This imbalance between the two networks has been proposed to underlie deficient emotion regulation in bipolar disorder.
Microenterprise development coupled with nutrition education can help increase caregivers' incomes and household accessibility to animal source foods

Low income and lack of knowledge about child nutrition have been identified as key constraints to the use of Animal Source Foods (ASF) in the diets of young Ghanaian children. To improve ASF consumption among children in Ghana, the Enhancing Child Nutrition through Animal Source Food Management (ENAM) project introduced an intervention that combined women’s microenterprise development activities with nutrition education on the importance of ASF in children’s diets. The present study assessed the effects of the intervention on the participants’ enterprise performance, their contribution to key household and child-related expenditures as well as their households’ purchases of ASF. Additionally, household ASF consumption was assessed in monetary terms (measured in Ghana cedis (GH¢):1GH¢ = US$ 0.92). A structured questionnaire was used to interview 80 caregivers who participated in the ENAM project activities in four intervention communities and 80 non-participant caregivers in four control communities. Information solicited included household characteristics, profits from microenterprises and contributions to household food and non-food expenditures. Significantly more participant caregivers expanded (P=0.004) and diversified (P=0.004) their enterprises and, as a result, tended to have higher average enterprise profits (GH¢19.3 ± 2.2 vs. GH¢12.2 ± 1.9; P=0.08) and significantly higher savings (GH¢62.9 ± 2.2 vs. GH¢26.3 ± 1.9; P<0.05) than non-participant caregivers. In addition, the intervention was associated with significantly higher percentage of monetary contributions by caregivers towards children’s health expenses (P<0.05), school expenses (P<0.01) as well as expenses on clothing and footwear (P<0.01). Caregivers’ mean percentage contribution to household food expenses also tended to be higher (P<0.1) for participants (50.8 ± 3.5%) then for non-participants (41.8 ± 4.1%). Participant households also tended to spend more money (P<0.10) and consumed significantly more amounts (in monetary value) of ASF (P<0.01) than non-participant households. Being a participant in the ENAM project’s microenterprise development and nutrition education activities was associated with higher enterprise profits, savings deposits, contributions to household and children-related expenditures, and ASF consumption at the household level.
ABC Transport Proteins in Cardiovascular Disease—A Brief Summary

Adenosine triphosphate (ATP)-binding cassette (ABC) transporters may play an important role in the pathogenesis of atherosclerotic vascular diseases due to their involvement in cholesterol homeostasis, blood pressure regulation, endothelial function, vascular inflammation, as well as platelet production and aggregation. In this regard, ABC transporters, such as ABCA1, ABCG5 and ABCG8, were initially found to be responsible for genetically-inherited syndromes like Tangier diseases and sitosterolemia. These findings led to the understanding of those transporter’s function in cellular cholesterol efflux and thereby also linked them to atherosclerosis and cardiovascular diseases (CVD). Subsequently, further ABC transporters, i.e., ABCG1, ABCG4, ABCB6, ABCC1, ABCC6 or ABCC9, have been shown to directly or indirectly affect cellular cholesterol efflux, the inflammatory response in macrophages, megakaryocyte proliferation and thrombus formation, as well as vascular function and blood pressure, and may thereby contribute to the pathogenesis of CVD and its complications. Furthermore, ABC transporters, such as ABCB1, ABCC2 or ABCG2, may affect the safety and efficacy of several drug classes currently in use for CVD treatment. This review will give a brief overview of ABC transporters involved in the process of atherogenesis and CVD pathology. It also aims to briefly summarize the role of ABC transporters in the pharmacokinetics and disposition of drugs frequently used to treat CVD and CVD-related complications.
Effect of Freeze–Thaw Cycles on Phosphorus Fractions and Their Availability in Biochar-Amended Mollisols of Northeast China (Laboratory Experiment)

Freeze–thaw cycles stimulate the release of available soil phosphorus (P) in winter, and biochar as a soil amendment could improve P availability. Nevertheless, it is unclear how freeze–thaw cycles and biochar amendment interact to affect the soil P fractions and their availability in winter, particularly under different soil water conditions. We simulateda freeze–thaw cycle experimentto assess the effects of three factors on soil P fractions: soil moisture content (22%, 31%, and 45%), frequencies of freeze–thaw cycles (0, 1, 3, 6, and 12 times) and biochar amendment (soil and biochar-amended soil). Modified Hedley sequential P fractionation was conducted to measure the soil P fractions. Increasing the number of freeze–thaw cycles increased soil labile P fractions in the soil with the lowest moisture content (22%). After biochar amendment, the content of labile P decreased as the number of freeze–thaw cycles increased. Biochar amendment enhanced P availability in Mollisols owing to the direct effect of NaOH-Po, which has a large direct path coefficient. Principal components analysis showed that moisture content was a major factor influencing the variation in the P fractions. The P fractions were separated by the interactive effects of biochar amendment and freeze–thaw cycles in soils with a higher moisture content (45%), indicating that the effects of freeze–thaw cycles on P availability appear to be more pronounced in biochar-amended Mollisols of higher water contents.
2018-0301 Ethnic Identity and School Belonging Among Pacific Islander High School Students

Ethnic Identity and School Belonging Among Pacific Islander High School Students in Utah Mari N. K. Oto Department of Teacher Education, BYU Master of Arts Pacific Islander high school students in the state of Utah specifically, but across the United States generally, face significant challenges such as high levels of high school dropout and low levels of academic attainment. The purpose of this study was to examine if components of an achieved ethnic identity (exploration and commitment) are positively related to high levels of school belonging among Pacific Islander high school students in Utah. I further investigated whether self-esteem was a mediating factor in any observed relationship between ethnic identity and school belonging. Participants in this study were Pacific Islander youth between the ages of 13-19 years old and attending high school in the state of Utah. The Multigroup Ethnic Identity Measure— Revised, Rosenberg Self-Esteem Inventory, Simple School Belonging Scale, and demographic questions were combined in a survey and taken by 111 participants. Results indicate a significantly positive relationship between school belonging and self-esteem (r = .39, p < .001). However, no relationship was observed between ethnic identity and school belonging. Results also suggests that self-esteem is not a mediating factor, nor is it related to ethnic identity individually for these students. Another purpose of this study was to better understand Pacific Islander students in our public education system, and especially in the state of Utah. Results revealed that ethnic identity may not operate in the same way for students in this study as has been suggested in the literature for other ethnic minorities. Specifically, ethnic identity, as measured by the MEIM-R may not represent the same construct, which leads to questions about how this sample was different than other national samples. The context of Utah may have been a determining factor and may play a role in the formation of ethnic identity for Pacific Islander students who live in Utah, especially for those who are also Latter-day Saint. Future research should look closely at the relationship between religiosity and ethnic identity for Pacific Islander students in Utah schools. The findings from this study also highlight the role of self-esteem in school belonging. They suggest a need to move beyond generalizations of this group of students as “minorities” to understanding how to increase their self-esteem in hopes of boosting their sense of belonging in our schools, thus leading to greater high school retention and academic achievement for this population.
Carboxyl/cholinesterases: a case study of the evolution of a successful multigene family

The evolution of organismal diversity among the Metazoa is dependent on the proliferation of genes and diversification of functions in multigene families. Here we analyse these processes for one highly successful family, the carboxyl/cholinesterases. One key to the expansion of the functional niche of this group of enzymes is associated with versatile substrate binding and catalytic machinery. Qualitatively new functions can be obtained by substitution of one or a very few amino acids. This crudely adapted new functionality is then refined rapidly by a pulse of change elsewhere in the molecule; in one case about 13% amino acid divergence occurred in 5–10 million years. Furthermore, we postulate that the versatility of the substrate binding motifs underpins the recruitment of several family members to additional noncatalytic signal transduction functions. BioEssays 21:1031–1042, 1999. © 1999 John Wiley & Sons, Inc.
DNA stabilization by the upregulation of estrogen signaling in BRCA gene mutation carriers

Currently available scientific evidence erroneously suggests that mutagenic weakness or loss of the BRCA1/2 genes may liberate the proliferative effects of estrogen signaling, which provokes DNA damage and genomic instability. Conversely, BRCA mutation seems to be an imbalanced defect, crudely inhibiting the upregulation of estrogen receptor expression and liganded transcriptional activity, whereas estrogen receptor-repressor functions become predominant. In BRCA-proficient cases, estrogen signaling orchestrates the activity of cell proliferation and differentiation with high safety, while upregulating the expression and DNA-stabilizing impact of BRCA genes. In turn, BRCA proteins promote estrogen signaling by proper estrogen synthesis via CYP19 gene regulation and by induction of the appropriate expression and transcriptional activity of estrogen receptors. In this exquisitely organized regulatory system, the dysfunction of each player may jeopardize genome stability and lead to severe chronic diseases, such as cancer development. Female organs, such as breast, endometrium, and ovary, exhibiting regular cyclic proliferative activity are particularly vulnerable in case of disturbances in either estrogen signaling or BRCA-mediated DNA repair. BRCA mutation carrier women may apparently be healthy or exhibit clinical signs of deficient estrogen signaling in spite of hyperestrogenism. Even women who enjoy sufficient compensatory DNA-defending activities are at risk of tumor development because many endogenous and environmental factors may jeopardize the mechanisms of extreme compensatory processes. Natural estrogens have numerous benefits in tumor prevention and therapy even in BRCA mutation carriers. There are no toxic effects even in sky-high doses and all physiologic cellular functions are strongly upregulated, while malignant tumor cells are recognized and killed in a Janus-faced manner.
Forecasting Net Foreign Direct Investment Inflows in India : Box-Jenkins ARIMA Model

The study is an attempt to build a time series model to forecast FDI inflows in India over the coming period. Annual time series data for the FDI in India was utilized over the period of 19922014. We have collected data mostly from (i) Reserve bank of India and various issues of (ii) Center for Monitoring Indian Economy (CMIE) website. This study employs Regression Analysis, Testing of Parameters, Box Jenkins methodology to build ARIMA (Autoregressive Integrated Moving Average). Accuracy and the selected models were tested by performing different diagnostics tests to ensure the accuracy of the results obtained. There have been enormous forecasting models ranging from simple models to sophisticated ones. We preferred Box – Jenkins model in our project not only due to its simplicity but also for its appropriateness with respect to our sample dataset. The empirical results obtained of ARIMA model have shown that FDI is following an increasing trend over the forecasted period (2015-2034). We used the computer program R GUI, Gretl and Eviews-7 for data analysis and forecasting.
Ex Vivo Modeling of Chemical Synergy in Prenatal Kidney Cystogenesis

Cyclic adenosine monophosphate (cAMP) drives genetic polycystic kidney disease (PKD) cystogenesis. Yet within certain PKD families, striking differences in disease severity exist between affected individuals, and genomic and/or environmental modifying factors have been evoked to explain these observations. We hypothesized that PKD cystogenesis is accentuated by an aberrant fetal milieu, specifically by glucocorticoids. The extent and nature of cystogenesis was assessed in explanted wild-type mouse embryonic metanephroi, using 8-Br-cAMP as a chemical to mimic genetic PKD and the glucocorticoid dexamethasone as the environmental modulator. Cysts and glomeruli were quantified by an observer blinded to culture conditions, and tubules were phenotyped using specific markers. Dexamethasone or 8-Br-cAMP applied on their own produced cysts predominantly arising in proximal tubules and descending limbs of loops of Henle. When applied together, however, dexamethasone over a wide concentration range synergized with 8-Br-cAMP to generate a more severe, glomerulocystic, phenotype; we note that prominent glomerular cysts have been reported in autosomal dominant PKD fetal kidneys. Our data support the idea that an adverse antenatal environment exacerbates renal cystogenesis.
A collaborative clinic between contraception and sexual health services and an adult congenital heart disease clinic

Background The success of cardiac surgery has created a new group of patients: those with ‘adult congenital heart disease’ (CHD) who may need specialist advice about contraception and pregnancy. The study objective was to investigate whether women with CHD were receiving appropriate advice on contraception. Methods The study setting comprised a combined adult CHD and contraception and sexual health clinic operating alongside each other, once a month, at Freeman Hospital, Newcastle-upon-Tyne, UK. Data were collected on 46 consecutive female patients attending the clinic between April 2002 and October 2003. Results Sixteen of the 46 (35%) women had never discussed contraception with a health professional. Nine of these women were sexually active and were using condoms. Seven of these women chose to start hormonal contraception following consultation. Ten of the 30 (33%) women who had previously discussed contraception with either their general practitioner or family planning clinic had received inappropriate advice. Of these 30 women, 24 needed contraception: 12 (50%) continued with their current method, 10 (42%) started hormonal contraception having previously used either condoms or no contraception and two (8%) changed their current hormonal method to a more effective long-term method (progestogen-only pill to progestogen implant). There had been eight unplanned pregnancies in seven patients. There was poor knowledge among the women about long-acting hormonal methods, particularly progestogen injectables and implants. Conclusions Our experience has highlighted the substandard provision of sexual health services for adults with CHD. Many of these women receive either no advice or inappropriate advice about contraception. Suitable effective reversible methods are often denied by health professionals who are concerned about the safety of hormonal contraceptives in women with ‘heart problems’. Preconception advice and birth control information should be given to all female patients with CHD, as correct information will avoid the potential risks of an unplanned pregnancy. A monthly regional combined clinic staffed by a cardiologist and family planning doctor provides the ideal opportunity for education of patients and health professionals alike. Good practice is then disseminated across specialities and into the community, encouraging multidisciplinary guidelines and pathways of referral to be developed.
Learning about Microorganisms in Childhood: Four- to Six-Year-Old Children’s Voice in Kindergartens and Museums

The main purpose of this research was to identify 4 to 6-year-old children’s ideas about microorganisms, taking into consideration the learning processes carried out in different educational contexts. To this end, data were collected from two institutions – a science museum and a kindergarten – by means of interviews, recorded conversations, drawings, and the application of a didactic sequence with the kindergarten group. A qualitative analysis of the data revealed that children associate the presence of microorganisms with dirty places and see them as pathological agents. The children demonstrated that they understand the idea of scale and the need for magnifying instruments. We found that they consider microorganisms morphologically similar to insects and that they use various scientific words appropriately. It was concluded that young children understand the theme “microorganisms”, and that it should be addressed more actively by institutions that teach four- to six-year-olds, which are responsible for contributing to their scientific literacy and science learning in childhood. It is proposed that the following themes be developed in educational activities with young children: biodiversity, scale, biological functions, and relationships with humans and food.
Osthole Attenuates Doxorubicin-Induced Apoptosis in PC12 Cells through Inhibition of Mitochondrial Dysfunction and ROS Production

Doxorubicin (DOX) is a potent, broad-spectrum chemotherapeutic drug used for treatment of several types of cancers. Despite its effectiveness, it has a wide range of toxic side effects, many of which most likely result from its inherent prooxidant activity. It has been reported that DOX has toxic effects on normal tissues, including brain tissue. In the current study, we investigated the protective effect of osthole isolated from Prangos ferulacea (L.) Lindl. on oxidative stress and apoptosis induced by DOX in PC12 as a neuronal model cell line. PC12 cells were pretreated with osthole 2 h after treatment with different concentrations of DOX. 24 h later, the cell viability, mitochondrial membrane potential (MMP), the activity of caspase-3, the expression ratio of Bax/Bcl-2, and the generation of intracellular ROS were detected. We found that pretreatment with osthole on PC12 cells significantly reduced the loss of cell viability, the activity of caspase-3, the increase in Bax/Bcl-2 ratio, and the generation of intracellular ROS induced by DOX. Moreover, pretreatment with osthole led to an increase in MMP in PC12 cells. In conclusion, our results indicated that pretreatment with nontoxic concentrations of osthole protected PC12 cells from DOX-mediated apoptosis by inhibition of ROS production.
Preventing fatal diseases increases healthcare costs: cause elimination life table approach

Abstract Objectives: To examine whether elimination of fatal diseases will increase healthcare costs. Design: Mortality data from vital statistics combined with healthcare spending in a cause elimination life table. Costs were allocated to specific diseases through the various healthcare registers. Setting and subjects: The population of the Netherlands, 1988. Main outcome measures: Healthcare costs of a synthetic life table cohort, expressed as life time expected costs. Results: The life time expected healthcare costs for 1988 in the Netherlands were £56 600 for men and £80 900 for women. Elimination of fatal diseases—such as coronary heart disease, cancer, or chronic obstructive lung disease—increases health- care costs. Major savings will be achieved only by elimination of non-fatal disease—such as musculoskeletal diseases and mental disorders. Conclusion: The aim of prevention is to spare people from avoidable misery and death not to save money on the healthcare system. In countries with low mortality, elimination of fatal diseases by successful prevention increases healthcare spending because of the medical expenses during added life years. Key messages In countries with low mortality prevention of fatal diseases adds life years predominantly to old age, when disabling conditions are prevalent If fatal diseases are eliminated, the medical costs of life extension at old age will generally be higher than the costs prevented. Prevention of disabling conditions, particularly mental disorders and musculoskeletal conditions, might both lower healthcare costs and improve public health The aim of prevention is to save people from preventable morbidity and mortality not to save money For the time being, prevention of disability should have the highest priority for future research
ANALYSING INCLUSIVE GROWTH: EMPIRICAL EVIDENCE FROM THE SLOVAK REPUBLIC

The presented paper aims to discuss the measurement of inclusive growth, using an abstraction, through which the inclusive growth is approximated as the pro-poor growth. Furthermore, we aim to provide an empirical evidence from the Slovak Republic. The analysis examines whether the economic growth achieved in the Slovak Republic during the time period from 2004 to 2009 had decreased the inequality of the income distribution of the households or not. During the analysis the Headcount index, the Poverty gap index and the Severity of poverty index are calculated and evaluated. The paper also provides estimation of the actual income distributions through the theoretical distributions, for the examined years. The results show rather negative relationship between growth and the decrease of income inequality.