Miracle-dz/UniFAR-FTUs huggingface dataset:
Ramping up the signal: promoting endurance training adaptation in skeletal muscle by nutritional manipulation

Mitochondrial biogenesis in skeletal muscle results from the cumulative effect of transient increases in mRNA transcripts encoding mitochondrial proteins in response to repeated exercise sessions. This process requires the coordinated expression of both nuclear and mitochondrial (mt) DNA genomes and is regulated, for the most part, by the peroxisome proliferator‐activated receptor γ coactivator 1α. Several other exercise‐inducible proteins also play important roles in promoting an endurance phenotype, including AMP‐activated protein kinase, p38 mitogen‐activated protein kinase and tumour suppressor protein p53. Commencing endurance‐based exercise with low muscle glycogen availability results in greater activation of many of these signalling proteins compared with when the same exercise is undertaken with normal glycogen concentration, suggesting that nutrient availability is a potent signal that can modulate the acute cellular responses to a single bout of exercise. When exercise sessions are repeated in the face of low glycogen availability (i.e. chronic training), the phenotypic adaptations resulting from such interventions are also augmented.
Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus

Background Previous research has suggested that thiazide diuretics and beta-blockers may promote the development of type 2 diabetes mellitus. However, the results of these studies have been inconsistent, and many studies have been limited by inadequate data on outcomes and by potential confounding. Methods We conducted a prospective study of 12,550 adults 45 to 64 years old who did not have diabetes. An extensive health evaluation conducted at base line included assessment of medication use and measurement of blood pressure with a random-zero sphygmomanometer. The incidence of new cases of diabetes was assessed after three years and after six years by measurement of serum glucose concentrations while the subjects were fasting. Results After simultaneous adjustment for age, sex, race, education, adiposity, family history with respect to diabetes, physical-activity level, other health-related behavior, and coexisting illnesses, subjects with hypertension who were taking thiazide diuretics were not at greate.
Cognitive processing in schizophrenia

I read the short report by Hall et al ([2004][1]) with interest. The authors reported a marked impairment in the ability of people with schizophrenia to make social judgements from facial expressions. Their findings complement and extend earlier studies by us and others ([Hellewell et al , 1994][2
PENGARUH KUALITAS PRODUK DAN HARGA TERHADAP KEPUASAN KONSUMEN “BEST AUTOWORKS”

Tujuan penelitian ini adalah untuk mengetahui pengaruh variabel kualitas produk (X1) dan harga (X2) terhadap kepuasan konsumen “Best Autoworks” (Y). Pada penelitian ini, ukuran sampel diambil dengan menggunakan rumus Hair berjumlah 85 orang yang berasal dari konsumen Best Autoworks. Teknik pengambilan sampel menggunakan simple random sampling. Data diambil menggunakan kuesioner yang diukur dengan skala Likert. Penelitian ini menggunakan analisis regresi linier berganda dengan bantuan program SPSS versi 20.0. Hasil penelitian ini menunjukkan bahwa variabel kualitas produk (X1) dan harga (X2) berpengaruh secara simultan terhadap kepuasan konsumen “Best Autoworks”. Variabel kualitas produk (X1) berpengaruh secara parsial namun harga (X2) tidak berpengaruh secara parsial terhadap kepuasan konsumen “Best Autoworks”.
Emotional Intelligence and Its Relationship to the Moderating Effect of Gender on the Students of Tafila Technical University

This study aims to identify the level of emotional intelligence of the students of Tafilah Technical University; in addition to finding out whether there are differences in levels of emotional intelligence amongst the two genders. A sample with 222 university students was selected, of which 117 were males, and 105 were females. The scale of emotional intelligence consisted of 41 phrases, which has five Likert steps, and the scale has three levels, viz., low, medium, and high. The results showed that the levels of emotional intelligence of the university students are average [3.195]. The females excelled the males in the level of emotional intelligence, in all dimensions. The average of the females’ grades reached 3.567, and the males’ average reached 2.865. The differences showed some statistical indications. The study recommends need of conducting training courses for the students to raise the level of emotional intelligence.
IMPROVED NOISE CANCELLATION IN DISCRETE COSINE TRANSFORM DOMAIN USING ADAPTIVE BLOCK LMS FILTER

This paper illustrates the advantages of Discrete Cosine Transform (DCT) when it is used in Block least mean square (BLMS) adaptive filter. DCT provides very good energy compaction in speech signals, image signals. So the signal to noise (SNR) is improved. Noise cancellation, Echo cancellation, System identification are the application of adaptive filter. We have proposed the Noise cancellation in DCT Domain and also compare with exist Fast Block LMS (FBLMS). The simulation result shows better signal to noise ratio (SNR) in DCT Domain rather than FFT Domain.
Direct Numerical Simulation of Some Fundamental Problems Related to Transition in Laminar Separation Bubbles

Direct Numerical Simulations of laminar separation bubbles are presented The bubbles are gen erated by prescribing a locally decelerated free stream velocity along a at plate Controlled disturbances are introduced into the ow eld upstream of the bubble by suction and blowing through the wall in order to study the linear and nonlinear stability characteristics of the ow Two generic cases with di erent two dimensional D and three dimensional D initial disturbance amplitudes are investigated a case S subject to sec ondary instability strong ampli cation of D disturb ances by resonance with a large amplitude D wave and a D nonlinear case O where two oblique waves with opposite wave angle interact After an initially very good agreement of the numerical results with pri mary and secondary instability it is found that the sec ondary instability in case S does not necessarily lead directly to D breakdown in contrast to the oblique mechanism in case O which is operative until sat uration of the D disturbances Recent results of the investigation of these mechanisms are presented in ad dition to investigations of the e ect of the wall on the instability of the ow The possible occurrence of an absolute instability is also checked in a numerical sim ulation
Concurrent Evaluation of Web Cache Replacement and Coherence Strategies

When studying Web cache replacement strategies, it is often assumed that documents are static. Such an assumption may not be realistic, especially when large-size caches are considered. Because of the strong correlation between the efficiency of the cache replacement strategy and the real state of the cached documents, one may expect dramatic changes of the cache performance when there is a possibility of hits on out-of-date documents. The authors’ aim in this study is to outline using simulation the impact of some cache coherence techniques such as the invalidation protocol, the TTL-based strategies, and prefetching on the efficiency of the cache replacement strategies. Using a simple cache model, they will show that the cache hits recorded when using some replacement strategies are more likely to be performed on out-of-date documents. They will show also the impact of the workload used on the outcome of the simulation.
Exploring dyslexics’ phonological deficit II: Phonological grammar

Language learners have to acquire the phonological grammar of their native language, and different levels of representations on which the grammar operates. Developmental dyslexia is associated with a phonological deficit, which is commonly assumed to stem from degraded phonological representations. The present study investigates one aspect of the phonological grammar, phonological assimilation rules. Specifically, it examines whether dyslexic adults have acquired phonological rules in speech production normally, and whether they compensate for them in perception. Contrary to the ‘degraded phonological representations hypothesis’, these adults produced phonological assimilations, and perceptually compensated for assimilations to the same extent as control participants. This suggests that individuals with dyslexia have acquired the phonological rules of their native language normally, and implies that they must have well-specified phonological representations, at least with respect to the features tested here. Nevertheless, these dyslexic adults still exhibit the typical phonological deficit as measured by phonological awareness, verbal short-term memory and rapid automatic naming tasks. Thus, it is suggested that the explanation for their phonological deficit must lie elsewhere than in their phonological representations and grammar.
The Faint End of the Luminosity Function of Galaxies in Hickson Groups

We study the luminosity function of galaxies in Hickson groups using our recent redshift survey of galaxies in and around 17 of these groups. We find that the galaxies in these regions have a luminosity function with M*=-19.5+5 log h and α=-1.0, where M* and α are the usual parameters in the standard Schechter form of the luminosity function and the magnitudes are measured in the B band. The formal 95% confidence intervals for M* and α range from (-19.3, -0.8) to (-19.7, -1.2) and are highly correlated, as is usual for these fits. This luminosity function for galaxies in our Hickson group sample is very similar to that found in large surveys covering a range of environments. These values are also consistent with our earlier estimates based on a photometric analysis with statistical background correction and do not support previous suggestions of an underabundance of intrinsically faint galaxies in compact groups. We confirm our earlier finding that the fainter galaxies are more diffusely distributed within individual groups than the brighter ones. This can be interpreted either as evidence for mass segregation within the groups or as the result of the selection procedure for Hickson groups.
The Bay Area Verbal Learning Test (BAVLT): Normative Data and the Effects of Repeated Testing, Simulated Malingering, and Traumatic Brain Injury

Verbal learning tests (VLTs) are widely used to evaluate memory deficits in neuropsychiatric and developmental disorders. However, their validity has been called into question by studies showing significant differences in VLT scores obtained by different examiners. Here we describe the computerized Bay Area Verbal Learning Test (BAVLT), which minimizes inter-examiner differences by incorporating digital list presentation and automated scoring. In the 10-min BAVLT, a 12-word list is presented on three acquisition trials, followed by a distractor list, immediate recall of the first list, and, after a 30-min delay, delayed recall and recognition. In Experiment 1, we analyzed the performance of 195 participants ranging in age from 18 to 82 years. Acquisition trials showed strong primacy and recency effects, with scores improving over repetitions, particularly for mid-list words. Inter-word intervals (IWIs) increased with successive words recalled. Omnibus scores (summed over all trials except recognition) were influenced by age, education, and sex (women outperformed men). In Experiment 2, we examined BAVLT test-retest reliability in 29 participants tested with different word lists at weekly intervals. High intraclass correlation coefficients were seen for omnibus and acquisition scores, IWIs, and a categorization index reflecting semantic reorganization. Experiment 3 examined the performance of Experiment 2 participants when feigning symptoms of traumatic brain injury. Although 37% of simulated malingerers showed abnormal (p < 0.05) omnibus z-scores, z-score cutoffs were ineffective in discriminating abnormal malingerers from control participants with abnormal scores. In contrast, four malingering indices (recognition scores, primacy/recency effects, learning rate across acquisition trials, and IWIs) discriminated the two groups with 80% sensitivity and 80% specificity. Experiment 4 examined the performance of a small group of patients with mild or severe TBI. Overall, both patient groups performed within the normal range, although significant performance deficits were seen in some patients. The BAVLT improves the speed and replicability of verbal learning assessments while providing comprehensive measures of retrieval timing, semantic organization, and primacy/recency effects that clarify the nature of performance.
A Semantic-based Approach for Exploring Consumer Health Questions Using UMLS

NetWellness is a non-profit web service providing high quality health information. It has been in operation since 1995 with over 13 million visits per year by consumers across the world in recent years. Consumer questions in NetWellness have been answered by medical and health professional faculties at three Ohio partner universities: Case Western Reserve University, the Ohio State University, and University of Cincinnati. However, the resident interface in NetWellness is ineffective in searching existing questions that have already been carefully answered by experts in an easy-to-understand manner. In our previous work, we presented a Conjunctive Exploratory Navigation Interface (CENI) reusing NetWellness' 120 pre-defined health topics in assisting question retrieval. This paper presents a novel semantic-based search interface called Semantic Conjunctive Exploratory Navigation Interface (SCENI), using UMLS concepts as topics. 60,000 questions were tagged by UMLS Concept Unique Identifies (CUIs), with each question allowing multiple possible tags. Using a slightly modified 5-point Likert scale for relevance, SCENI reveals improved precision and relevance (precision: 93.47%, relevance: 4.31) in comparison to CENI using NetWellness' pre-defined topics alone (precision: 77.85%, relevance: 3.3) and NetWellness' resident search interface (precision: 50.62%, relevance: 1.97), on a set of sample queries.
Protection of the Extracts of Lentinus edodes Mycelia against Carbon-Tetrachloride-Induced Hepatic Injury in Rats

Lentinus edodes is the medicinal macrofungus showing potential for therapeutic applications in infectious disorders including hepatitis. In an attempt to develop the agent for handling hepatic injury, we used the extracts of Lentinus edodes mycelia (LEM) to screen the effect on hepatic injury in rats induced by carbon tetrachloride (CCl4). Intraperitoneal administration of CCl4 not only increased plasma glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) but also decreased hepatic superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels in rats. Similar to the positive control silymarin, oral administration (three times daily) of this product (LEM) for 8 weeks significantly reduced plasma GOT and GPT. Also, the activities of antioxidant enzymes of SOD and GPx were elevated by LEM. in liver from CCl4-treated rats, indicating that mycelium can increase antioxidant-like activity. Moreover, the hepatic mRNA and protein levels of SOD and GPx were both markedly raised by LEM. The obtained results suggest that oral administration of the extracts of Lentinus edodes mycelia (LEM) has the protective effect against CCl4-induced hepatic injury in rats, mainly due to an increase in antioxidant-like action.
Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis

Infection by pathogenic fungi, such as Candida albicans, begins with adhesion to host cells or implanted medical devices followed by biofilm formation. By high-throughput phenotypic screening of small molecules, we identified compounds that inhibit adhesion of C. albicans to polystyrene. Our lead candidate compound also inhibits binding of C. albicans to cultured human epithelial cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter, biofilm formation on silicone elastomers, and pathogenesis in a nematode infection model as well as alters fungal morphology in a mouse mucosal infection assay. We term this compound filastatin based on its strong inhibition of filamentation, and we use chemical genetic experiments to show that it acts downstream of multiple signaling pathways. These studies show that high-throughput functional assays targeting fungal adhesion can provide chemical probes for study of multiple aspects of fungal pathogenesis.
Expression of A-, B-, and C-type natriuretic peptide genes in failing and developing human ventricles. Correlation with expression of the Ca(2+)-ATPase gene.

Brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are novel natriuretic peptides, originally isolated from porcine brain. Similar to atrial natriuretic peptide (ANP), BNP is also synthesized in and secreted from cardiocytes, but CNP is not expressed at significant levels in normal adult myocardium. Previous studies have indicated that the serum level and ventricular expression of the ANP gene were augmented in patients with heart failure. Recently, the serum level of BNP was also reported to increase in human heart failure. To examine whether or not the expression of these natriuretic peptides is regulated in ventricular myocardium in a concordant manner, we performed Northern blot analysis using total cellular RNA isolated from the diseased left ventricles of 30 cardiac transplant recipients with end-stage heart failure, seven ventricles from organ donors (control group), and two ventricles of artificially aborted 17- and 19-week-old fetuses. The levels of mRNAs encoding both BNP and ANP increased significantly (p less than 0.01) in the left ventricular myocardium from the patients with end-stage heart failure as compared with the control group. The levels of BNP mRNA correlated positively with those of ANP mRNA (r = 0.73, p less than 0.01) and negatively with those of sarcoplasmic reticulum Ca(2+)-ATPase mRNA (r = -0.66, p less than 0.01) in the left ventricular myocardium from the patients with heart failure. There was also a negative correlation between the levels of ANP and the sarcoplasmic reticulum Ca(2+)-ATPase mRNAs (r = -0.65, p less than 0.01). (ABSTRACT TRUNCATED AT 250 WORDS)
Beat estimation on the beat

The paper presents a novel method for the estimation of beat interval, and the exact location of the beats, from audio files. As a first step, a feature extracted from the waveform is used to identify note onsets. The estimated note onsets are used as input to a beat induction algorithm, where the most probable beat intervals are found. The note onsets corresponding to the beat locations are then identified. Several enhancements are proposed, including methods for identifying the optimum audio feature, a novel weighting system in the beat induction algorithm and a simple robust method for identifying the beat locations. The resulting system runs in real-time, and is shown to work well for a wide variety of contemporary and popular rhythmic music.
Airborne‐radar and ice‐core observations of annual snow accumulation over Thwaites Glacier, West Antarctica confirm the spatiotemporal variability of global and regional atmospheric models

We use an airborne‐radar method, verified with ice‐core accumulation records, to determine the spatiotemporal variations of snow accumulation over Thwaites Glacier, West Antarctica between 1980 and 2009. We also present a regional evaluation of modeled accumulation in Antarctica. Comparisons between radar‐derived measurements and model outputs show that three global models capture the interannual variability well (r > 0.9), but a high‐resolution regional model (RACMO2) has better absolute accuracy and captures the observed spatial variability (r = 0.86). Neither the measured nor modeled accumulation records over Thwaites Glacier show any trend since 1980. Although an increase in accumulation may potentially accompany the observed warming in the region, the projected trend is too small to detect over the 30 year record.
Semantic organization in children with cochlear implants: computational analysis of verbal fluency

Purpose: Cochlear implants (CIs) enable children with severe and profound hearing impairments to perceive the sensation of sound sufficiently to permit oral language acquisition. So far, studies have focused mainly on technological improvements and general outcomes of implantation for speech perception and spoken language development. This study quantitatively explored the organization of the semantic networks of children with CIs in comparison to those of age-matched normal hearing (NH) peers. Method: Twenty seven children with CIs and twenty seven age- and IQ-matched NH children ages 7–10 were tested on a timed animal verbal fluency task (Name as many animals as you can). The responses were analyzed using correlation and network methodologies. The structure of the animal category semantic network for both groups were extracted and compared. Results: Children with CIs appeared to have a less-developed semantic network structure compared to age-matched NH peers. The average shortest path length (ASPL) and the network diameter measures were larger for the NH group compared to the CIs group. This difference was consistent for the analysis of networks derived from animal names generated by each group [sample-matched correlation networks (SMCN)] and for the networks derived from the common animal names generated by both groups [word-matched correlation networks (WMCN)]. Conclusions: The main difference between the semantic networks of children with CIs and NH lies in the network structure. The semantic network of children with CIs is under-developed compared to the semantic network of the age-matched NH children. We discuss the practical and clinical implications of our findings.
The Relationship Among Leadership, Organizational Culture And Employees' Job Satisfaction

The increasing interest in employees satisfaction has heightened the need for analyzing the factors which contribute to this. The purpose of this paper is to evidence the influence of the style of leadership and the organizational culture on the employees satisfaction at work. In this study we analyze the influence of the bureaucratic leadership, the tranzactional leadership, the transformational leadership and the servant leadership. We can not afirm exactly which style of leadership is the most effective because no leadership style is guaranted to work in all situations. We made our research by analysing the style of leadership and the organizational culture at the Lagardere Travel Retail Romania. We attended several meetings to observe what style of leadersip predominates and we questioned the employees about the values of the organizational culture to establish it’s type and it’s role in motivating the employees.