Miracle-dz/UniFAR-FTUs huggingface dataset:
ULTRACAM photometry of the ultracompact binaries V407 Vul and HM Cnc

V407 Vul (RXJ1914.4+2456) and HM Cnc (RXJ0806.3+1527) are X-ray emitting stars with X-ray light curves that are 100 per cent modulated on periods of 569 and 321 s, respectively. These periods are thought possibly to represent the orbital periods of close pairs of white dwarfs. In this paper we present optical light curves taken with the high-speed CCD camera ULTRACAM on the 4.2-m William Hershel Telescope in 2003 May and 2005 August and with the VLT in 2005 November. The optical and X-ray light curves of HM Cnc have been reported as being in antiphase, but we find that in fact the X-rays peak around 0.2 cycles after the maximum of the optical light, as seen also in V407 Vul. The X-ray/optical phase shifts are well explained under the accreting models of the systems if most of the optical modulation comes from the heated faces of the mass donors and if the X-ray emitting spots are positioned in advance of the mass donors, as is expected given the angular momentum of the accreting material. Some optical emission may also come from the vicinity of the X-ray spot, and we further show that this can explain the non-sinusoidal light curves of HM Cnc. On the basis of this model we constrain the temperature of the heated face of the companion star finding a bolometric luminosity > 10(33) erg s(-1) and a distance, d > 1.1 kpc. We can identify no explanation for the X-ray/optical phase shifts under the intermediate polar and unipolar inductor models of the systems. The only significant difference between the two stars is that V407 Vul is observed to have the spectrum of a G star. The variation in position on the sky of a blend of a variable and a constant star can be used as a measure of their separation, and is sensitive to values well below the limit set by seeing. We apply this 'pulsation astrometry' to deduce that the G star is separated from the variable by about 0.027 arcsec and hence plays no role in the variability of V407 Vul. We show that light traveltime variations could influence the period change in V407 Vul if it forms a triple system with the G star.
Interleukin-12: Biological Properties and Clinical Application

Interleukin-12 (IL-12) is a heterodimeric protein, first recovered from EBV-transformed B cell lines. It is a multifunctional cytokine, the properties of which bridge innate and adaptive immunity, acting as a key regulator of cell-mediated immune responses through the induction of T helper 1 differentiation. By promoting IFN-γ production, proliferation, and cytolytic activity of natural killer and T cells, IL-12 induces cellular immunity. In addition, IL-12 induces an antiangiogenic program mediated by IFN-γ–inducible genes and by lymphocyte-endothelial cell cross-talk. The immunomodulating and antiangiogenic functions of IL-12 have provided the rationale for exploiting this cytokine as an anticancer agent. In contrast with the significant antitumor and antimetastatic activity of IL-12, documented in several preclinical studies, clinical trials with IL-12, used as a single agent, or as a vaccine adjuvant, have shown limited efficacy in most instances. More effective application of this cytokine, and of newly identified IL-12 family members (IL-23 and IL-27), should be evaluated as therapeutic agents with considerable potential in cancer patients.
A uniform X-ray analysis of 79 distant galaxy clusters with ROSAT and ASCA

We present a uniform analysis of the ROSAT HRI and the ASCA GIS/SIS data for 79 distant clusters of galaxies in the redshift range 0.1 < z < 0.82 to study the global structures of the intracluster medium. We have constructed an X-ray catalog consisting of the largest sample of clusters in the redshift range for which pointed X-ray observations were carried out with both the observatories. We determined the emission-weighted X-ray temperatures of the clusters with ASCA, while we studied surface brightness distribution with the ROSAT HRI utilizing the isothermal β model. We investigated the statistical properties and trends for redshift evolution of the X-ray parameters including the temperature, the density profile of the intracluster gas and the gas-mass fraction within r500. We also present correlations of the cluster parameters with the X-ray temperature and with the core radius and compare them with the predictions of the self-similar model, from which we discuss the possible origin of the double structure discovered in the core radius distribution.
The Wisconsin Predicting Patients' Relapse questionnaire.

INTRODUCTION Relapse is the most common smoking cessation outcome. Accurate prediction of relapse likelihood could be an important clinical tool used to influence treatment selection or duration. The aim of this research was to develop a brief clinical relapse proneness questionnaire to be used with smokers interested in quitting in a clinical setting where time is at a premium. METHODS Diverse items assessing constructs shown in previous research to be related to relapse risk, such as nicotine dependence and self-efficacy, were evaluated to determine their independent contributions to relapse prediction. In an exploratory dataset, candidate items were assessed among smokers motivated to quit smoking who enrolled in one of three randomized controlled smoking cessation trials. A cross-validation dataset was used to compare the relative predictive power of the new instrument against the Fagerström Test for Nicotine Dependence (FTND) at 1-week, 8-week, and 6-month postquit assessments. RESULTS We selected seven items with relatively nonoverlapping content for the Wisconsin Predicting Patient's Relapse (WI-PREPARE) measure, a brief, seven-item questionnaire that taps physical dependence, environmental factors, and individual difference characteristics. Cross-validation analyses suggested that the WI-PREPARE demonstrated a stronger prediction of relapse at 1-week and 8-week postquit assessments than the FTND and comparable prediction to the FTND at a 6-month postquit assessment. DISCUSSION The WI-PREPARE is easy to score, suggests the nature of a patient's relapse risk, and predicts short- and medium-term relapse better than the FTND.
Bacterial decolorization of textile dyes is an extracellular process requiring a multicomponent electron transfer pathway

Many studies have reported microorganisms as efficient biocatalysts for colour removal of dye‐containing industrial wastewaters. We present the first comprehensive study to identify all molecular components involved in decolorization by bacterial cells. Mutants from the model organism Shewanella oneidensis MR‐1, generated by random transposon and targeted insertional mutagenesis, were screened for defects in decolorization of an oxazine and diazo dye. We demonstrate that decolorization is an extracellular reduction process requiring a multicomponent electron transfer pathway that consists of cytoplasmic membrane, periplasmic and outer membrane components. The presence of melanin, a redox‐active molecule excreted by S. oneidensis, was shown to enhance the dye reduction rates. Menaquinones and the cytochrome CymA are the crucial cytoplasmic membrane components of the pathway, which then branches off via a network of periplasmic cytochromes to three outer membrane cytochromes. The key proteins of this network are MtrA and OmcB in the periplasm and outer membrane respectively. A model of the complete dye reduction pathway is proposed in which the dye molecules are reduced by the outer membrane cytochromes either directly or indirectly via melanin.
Trans-lesion synthesis and RNaseH activity by reverse transcriptases on a true abasic RNA template

While much is known about abasic DNA, the biological impact of abasic RNA is largely unexplored. To test the mutagenic potential of this RNA lesion in the context of retroviruses, we synthesized a 31-mer oligoribonucleotide containing an abasic (rAS) site and used it as a template for studying DNA primer extension by HIV-1, avian myeloblastosis virus (AMV) and moloney murine leukemia virus (MMLV) reversed transcriptases (RT). We found that trans-lesion synthesis readily takes place with HIV-1 RT and to a lesser extent with AMV RT while MMLV RT aborts DNA synthesis. The preference of dNTP incorporation follows the order A∼G > C∼T and thus obeys to the ‘A-rule’. In the case of HIV-1 RT, we measured the kinetic data of dNTP incorporation and compared it to abasic DNA. We found that A-incorporation is only 2-fold slower relative to a matched (undamaged) RNA template while it is 7-fold slower in the case of DNA. Furthermore, there is less discrimination in incorporation between the four dNTPs in the case of abasic RNA compared to abasic DNA. These experiments clearly point to a higher promiscuity of lesion bypass on abasic RNA. Given their known higher chemical stability, such rAS sites can clearly contribute to (retro)viral evolution.
Intrinsic signal optical imaging evidence for dorsal V3 in the prosimian galago (Otolemur garnettii)

Currently, we lack consensus regarding the organization along the anterior border of dorsomedial V2 in primates. Previous studies suggest that this region could be either the dorsomedial area, characterized by both an upper and a lower visual field representation, or the dorsal aspect of area V3, which only contains a lower visual field representation. We examined these proposals by using optical imaging of intrinsic signals to investigate this region in the prosimian galago (Otolemur garnettii). Galagos represent the prosimian radiation of surviving primates; cortical areas that bear strong resemblances across members of primates provide a strong argument for their early origin and conserved existence. Based on our mapping of horizontal and vertical meridian representations, visuotopy, and orientation preference, we find a clear lower field representation anterior to dorsal V2 but no evidence of any upper field representation. We also show statistical differences in orientation preference patches between V2 and V3. We additionally supplement our imaging results with electrode array data that reveal differences in the average spatial frequency preference, average temporal frequency preference, and sizes of the receptive fields between V1, V2, and V3. The lack of upper visual field representation along with the differences between the neighboring visual areas clearly distinguish the region anterior to dorsal V2 from earlier visual areas and argue against a DM that lies along the dorsomedial border of V2. We submit that the region of the cortex in question is the dorsal aspect of V3, thus strengthening the possibility that V3 is conserved among primates. J. Comp. Neurol. , 2012. © 2012 Wiley Periodicals, Inc.
Performance Evaluation of Unified Parallel C Collective Communications

Unified Parallel C (UPC) is an extension of ANSI C designed for parallel programming. UPC collective primitives, which are part of the UPC standard, increase programming productivity while reducing the communication overhead. This paper presents an up-to-date performance evaluation of two publicly available UPC collective implementations on three scenarios: shared, distributed, and hybrid shared/distributed memory architectures. The characterization of the throughput of collective primitives is useful for increasing performance through the runtime selection of the appropriate primitive implementation, which depends on the message size and the memory architecture, as well as to detect inefficient implementations. In fact, based on the analysis of the UPC collectives performance, we proposed some optimizations for the current UPC collective libraries. We have also compared the performance of the UPC collective primitives and their MPI counterparts, showing that there is room for improvement. Finally, this paper concludes with an analysis of the influence of the performance of the UPC collectives on a representative communication-intensive application, showing that their optimization is highly important for UPC scalability.
Fruit, vegetables, dietary fiber, and risk of colorectal cancer.

BACKGROUND Several recent large prospective cohort studies have failed to demonstrate the presumed protective effect of fruit, vegetable, and dietary fiber consumption on colorectal cancer risk. To further explore this issue, we have examined these associations in a population that consumes relatively low amounts of fruit and vegetables and high amounts of cereals. METHODS We examined data obtained from a food-frequency questionnaire used in a population-based prospective mammography screening study of women in central Sweden. Women with colorectal cancer diagnosed through December 31, 1998, were identified by linkage to regional cancer registries. Cox proportional hazards models were used to estimate relative risks. All statistical tests were two-sided. RESULTS During an average 9.6 years of follow-up of 61 463 women, we observed 460 incident cases of colorectal cancer (291 colon cancers, 159 rectal cancers, and 10 cancers at both sites). In the entire study population, total fruit and vegetable consumption was inversely associated with colorectal cancer risk. Subanalyses showed that this association was due largely to fruit consumption. The association was stronger, however, and the dose-response effect was more evident among individuals who consumed the lowest amounts of fruit and vegetables. Individuals who consumed less than 1.5 servings of fruit and vegetables per day had a relative risk for developing colorectal cancer of 1.65 (95% confidence interval = 1.23 to 2.20; P(trend) =. 001) compared with individuals who consumed more than 2.5 servings. We observed no association between colorectal cancer risk and the consumption of cereal fiber, even at amounts substantially greater than previously examined, or of non-cereal fiber. CONCLUSIONS Individuals who consume very low amounts of fruit and vegetables have the greatest risk of colorectal cancer. Relatively high consumption of cereal fiber does not appear to lower the risk of colorectal cancer.
New Approach to Bankruptcy Prediction using Genetic Algorithm

In this research the bankruptcy of companies has been surveyed through the genetic algorithm. To do this and in order to design its related genetic model, the financial ratios have been used and a genetic model has been presented in order to predict bankruptcy of the accepted companies in Tehran Stock Exchange Market. Formulating the related model has been done through the relevant data of two groups of the companies accepted as those in Tehran Stock Exchange Market. The first group consists of 40 non-bankrupt companies, and the second one like the first group includes 40 companies but they were bankrupt ones. The model is represented by using 24 financial ratios consisting of 4 groups of liquidation, profitability, activity, and leverage ratios (Capital Structure). The main point of this essay is that unlike the other previous methods which just present the genetic algorithms to solve the problem of predicting bankruptcy, here in this article in addition to focusing on the solution for the problem, the presented model has used the related algorithm in order to learn and converge on the appropriate answer. The test results of the prediction capability of the model indicates the fact that the presented model can predict the companies' bankruptcy and non-bankruptcy accurately and with the least error some years before they really occurs, and by passing the time of bankruptcy, its prediction ability decreases since its prediction indexes become weak gradually. The results of this study present the efficient functions of this method used by different researches.
Divergence of East Asians and Europeans Estimated Using Male- and Female-Specific Genetic Markers

To study the male and female lineages of East Asian and European humans, we have sequenced 25 short tandem repeat markers on 453 Y-chromosomes and collected sequences of 72 complete mitochondrial genomes to construct independent phylogenetic trees for male and female lineages. The results indicate that East Asian individuals fall into two clades, one that includes East Asian individuals only and a second that contains East Asian and European individuals. Surprisingly, the European individuals did not form an independent clade, but branched within in the East Asians. We then estimated the divergence time of the root of the European clade as ∼41,000 years ago. These data indicate that, contrary to traditional views, Europeans diverged from East Asians around that time. We also address the origin of the Ainu lineage in northern Japan.
CrowdStudy: general toolkit for crowdsourced evaluation of web interfaces

While traditional usability testing methods can be both time consuming and expensive, tools for automated usability evaluation tend to oversimplify the problem by limiting themselves to supporting only certain evaluation criteria, settings, tasks and scenarios. We present CrowdStudy, a general web toolkit that combines support for automated usability testing with crowdsourcing to facilitate large-scale online user testing. CrowdStudy is based on existing crowdsourcing techniques for recruiting workers and guiding them through complex tasks, but implements mechanisms specifically designed for usability studies, allowing testers to control user sampling and conduct evaluations for particular contexts of use. Our toolkit provides support for context-aware data collection and analysis based on an extensible set of metrics, as well as tools for managing, reviewing and analysing any collected data. The paper demonstrates several useful features of CrowdStudy for two different scenarios, and discusses the benefits and tradeoffs of using crowdsourced evaluation.
Overexpression of Medicago SVP genes causes floral defects and delayed flowering in Arabidopsis but only affects floral development in Medicago

The MADS-domain transcription factor SHORT VEGETATIVE PHASE plays a key role as a repressor of the transition to flowering and as a regulator of early floral development in Arabidopsis thaliana (Arabidopsis). However, no flowering-time repressors have been functionally identified in the model legume Medicago truncatula (Medicago). In this study, phylogenetic analysis of two closely-related MtSVP-like sequences, MtSVP1 and MtSVP2, showed that their predicted proteins clustered together within the eudicot SVP clade. To determine if the MtSVP-like genes have a role in flowering, they were functionally characterized in Medicago and Arabidopsis. Transcripts of both MtSVP genes were abundant and broadly expressed in vegetative tissues but were detected at much lower levels in flowers in Medicago. Over-expression of the MtSVP genes in Arabidopsis resulted in delayed flowering and flowers with many abnormal phenotypes such as leafy sepals, changes to floral organ number and longer pedicels than the wild type. By contrast, in transgenic Medicago, over-expression of MtSVP1 resulted in alterations to flower development, but did not alter flowering time, suggesting that MtSVP1 may not function to repress the transition to flowering in Medicago.
Conservative and Surgical Treatment Improves Pain and Ankle-Brachial Index in Patients with Lumbar Spinal Stenosis

Purpose The pathological mechanism of lumbar spinal stenosis is reduced blood flow in nerve roots and degeneration of nerve roots. Exercise and prostaglandin E1 is used for patients with peripheral arterial disease to increase capillary flow around the main artery and improve symptoms; however, the ankle-brachial index (ABI), an estimation of blood flow in the main artery in the leg, does not change after treatment. Lumbar spinal nerve roots contain somatosensory, somatomotor, and unmyelinated autonomic nerves. Improved blood flow by medication with prostaglandin E1 and decompression surgery in these spinal nerve roots may improve the function of nerve fibers innervating muscle, capillary, and main vessels in the lower leg, resulting in an increased ABI. The purpose of the study was to examine whether these treatments can improve ABI. Materials and Methods One hundred and seven patients who received conservative treatment such as exercise and medication (n=56) or surgical treatment (n=51) were included. Low back pain and leg pain scores, walking distance, and ABI were measured before treatment and after 3 months of conservative treatment alone or surgical treatment followed by conservative treatment. Results Low back pain, leg pain, and walking distance significantly improved after both treatments (p<0.05). ABI significantly increased in each group (p<0.05). Conclusion This is the first investigation of changes in ABI after treatment in patients with lumbar spinal stenosis. Improvement of the spinal nerve roots by medication and decompression surgery may improve the supply of blood flow to the lower leg in patients with lumbar spinal stenosis.
Response of submarine hydrologic monitoring instruments to formation pressure changes: Theory and application to Nankai advanced CORKs

[1] We describe the response of a compressible submarine hydrologic monitoring instrument to formation pressure changes in low-diffusivity rock. The measured pressure depends on the frequency of the pressure signal, the hydraulic diffusivity, and the wellbore storage. The Nankai advanced circulation obviation retrofit kits (ACORKs) (offshore Japan) record tide-induced formation pressure changes with small amplitudes ( 25°). The pressure measurements occur in thick, homogeneous, compressible, low-permeability sediment, where in situ tidal pressure responses should approximate the seafloor tidal signal. A wellbore storage of 2 × 10−8 m3 Pa−1 can explain many of the observed tidal responses, given the hydraulic diffusivities of the monitored intervals. A reduced permeability around the wellbore of 1000-fold and a wellbore storage of 10−11 m3 Pa−1 can also reconcile the data. Our analysis suggests that ACORK screens in the Lower Shikoku Basin facies have a critical frequency on the order of 5 × 10−8 Hz (equivalent to a period of 250 days); higher-frequency formation pressure signals will be distorted in the pressure record. Within the Lower Shikoku Basin facies the time for this monitoring system to record 90% of an instantaneous pressure change is on the order of 10 d. We suggest that the ACORK instrument compliance contributes to, but does not fully explain, the small tidal amplitudes and large phase shifts recorded at the least permeable monitoring intervals.
Mealybug Chromosome Cycle as a Paradigm of Epigenetics

Recently, epigenetics has had an ever-growing impact on research not only for its intrinsic interest but also because it has been implied in biological phenomena, such as tumor emergence and progression. The first epigenetic phenomenon to be described in the early 1960s was chromosome imprinting in some insect species (sciaridae and coccoideae). Here, we discuss recent experimental results to dissect the phenomenon of imprinted facultative heterochromatinization in Lecanoid coccids (mealybugs). In these insect species, the entire paternally derived haploid chromosome set becomes heterochromatic during embryogenesis in males. We describe the role of known epigenetic marks, such as DNA methylation and histone modifications, in this phenomenon. We then discuss the models proposed to explain the noncanonical chromosome cycle of these species.
Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection

Parvovirus B19 (B19) infection can occur during acute lymphoblastic leukemia and persistent viral infection can occur despite intravenous immunoglobulin administration. Here, evidence is presented that resolution of persistent B19 infection in an acute lymphoblastic leukemia patient may be associated with the simultaneous strengthening of antigen‐specific B cell memory against the B19 capsid protein VP2 and diminution in the memory response against the B19 non‐structural protein 1 (NS1). Determination of antigen‐specific B cell memory status may enhance the serological and molecular analyses of persistent B19 infection. J. Med. Virol. 78:125–128, 2006. © 2005 Wiley‐Liss, inc.