Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutrition and metabolism of marine bacteria. XIV. On the mechanism of lysis of a marine bacterium.

Electron micrographs of thin sections of cell envelope preparations of a marine pseudomonad suspended in 0.5 M NaCl showed the presence of two unit membranes at the periphery. When suspended in 0.01 M NaCl the two membranes became infinitely separated and both non-dialyzable and dialyzable material appeared in solution. The composition of the non-dialyzable fraction indicated that it was derived from a mucopeptide layer. This layer was not visualized but at a high enough salt concentration is believed to lie between the two unit membranes and to play a role in holding the membranes together. Both heated and unheated envelope suspensions released hexosamine-containing material at low salt concentration. Lowering the salt concentration of the suspension caused an immediate rise in pH of the suspending solution. The effects of temperature and salts on the release of the hexosamine-containing fraction were analogous to the effects of temperature and salts on the denaturation of a polyanion and are explainable.
In Vivo Imaging of Mineral Deposition in Carotid Plaque Using 18F-Sodium Fluoride PET/CT: Correlation with Atherogenic Risk Factors

The purpose of this study was to correlate 18F-sodium fluoride accumulation in the common carotid arteries of neurologically asymptomatic patients with cardiovascular risk factors and carotid calcified plaque burden. Methods: Two hundred sixty-nine oncologic patients were examined by 18F-sodium fluoride PET/CT. Tracer accumulation in the common carotid arteries was analyzed both qualitatively and semiquantitatively by measuring the blood-pool–corrected standardized uptake value (target-to-background ratio) and comparing it with cardiovascular risk factors and calcified plaque burden. Results: 18F-sodium fluoride uptake was observed at 141 sites in 94 (34.9%) patients. Radiotracer accumulation was colocalized with calcification in all atherosclerotic lesions. 18F-sodium fluoride uptake was significantly associated with age (P < 0.0001), male sex (P < 0.0001), hypertension (P < 0.002), and hypercholesterolemia (P < 0.05). The presence of calcified plaque correlated significantly with these risk factors but also with diabetes (P < 0.0001), history of smoking (P = 0.03), and prior cardiovascular events (P < 0.01). There was a highly significant correlation between the presence of 18F-sodium fluoride uptake and number of present cardiovascular risk factors (r = 0.30, P < 0.0001). Conclusion: Carotid 18F-sodium fluoride uptake is a surrogate measure of calcifying carotid plaque, correlates with cardiovascular risk factors, and is more frequent in patients with a high-risk profile for atherothrombotic events but demonstrates a weaker correlation with risk factors than does calcified plaque burden. This study provides a rationale to conduct further prospective studies to determine whether 18F-sodium fluoride uptake can predict vascular events, or if it may be used to monitor pharmacologic therapy.
Caspase Activation in Hair Cells of the Mouse Utricle Exposed to Neomycin

Aminoglycoside exposure results in the apoptotic destruction of auditory and vestibular hair cells. This ototoxic hair cell death is prevented by broad-spectrum caspase inhibition. We have used in situ substrate detection, immunohistochemistry, and specific caspase inhibitors to determine which caspases are activated in the hair cells of the adult mouse utricle in response to neomycin exposurein vitro. In addition, we have examined the hierarchy of caspase activation. Our data indicate that both upstream caspase-8 and upstream caspase-9, as well as downstream caspase-3 are activated in hair cells exposed to neomycin. The inhibition of caspase-9-like activity provided significant protection of hair cells exposed to neomycin, whereas the inhibition of caspase-8-like activity was not effective in preventing neomycin-induced hair cell death. In addition, caspase-9 inhibition prevented the activation of downstream caspase-3, whereas the inhibition of caspase-8 did not. These data indicate that caspase-9 is the primary upstream caspase mediating neomycin-induced hair cell death in this preparation.
The Concept of Weather Event: A Qualitative Perspective from Students1

Abstract This paper aimed at determining the perceptions of 6th grade primary school students with regards to the concept of “Weather Event” included in the 4th and 5th grade Social Studies curriculum. The study group consisted of 242 sixth grade students from 6 different public schools located in the central district of Karabuk Province in the spring semester of the 2012-2013 academic year. The research data were collected via the forms prepared by the researcher containing the statement, “Weather event… is like… This isbecause; …” and the pictures/cartoons which the students were asked to draw in regard to the concept of “Weather Event”. The qualitative research method and the phenomenological design were employed in the study. The data were analyzed through content analysis. Results revealed that the students produced 34 metaphors in regard to the concept of weather event. These metaphors were divided into 5 different categories. It was concluded that a great majority of the participants perceived the concept of “Weather Event” as “changing depending on the conditions”, “involving uncertainties”, and “continuities”.
Coagulation Factor XIII-A Val34Leu Polymorphism and the Risk of Coronary Artery Disease and Myocardial Infarction in a Chinese Han Population

There are controversial data regarding the impact of coagulation factor XIII A subunit (FXIII-A) Val34Leu polymorphism in the pathogeneric of coronary artery disease (CAD) and myocardial infarction (MI). Assuming this genetic factor is associated with the thrombotic process, we explored the role of FXIII-A Val34Leu in CAD and MI in a Chinese Han population. We recruited 195 consecutive patients with CAD confirmed by coronary angiography as well as a group of 203 controls. Factor XIII A Val34Leu polymorphism was determined through polymerase chain reaction—single strand conformational polymorphism (PCR-SSCP) analysis. We did not find the Leu/Leu genotype in patients with CAD or controls. No significant difference in Val34Leu gene polymorphism distribution was found between patients with CAD and the controls (P = .923). Subgroup analysis according to the history of MI showed the heterozygote Val/Leu genotype was associated with a significantly decreased risk of MI (P = .005; adjusted odds ratio [OR] = 1.75; 95% confidence interval [CI] = 1.28-2.25). Furthermore, our study displayed that the frequency of the Leu34 allele in a Chinese Han population was lower than that in Caucasian populations (2.5 vs 20.4%-28.3%). Our preliminary data indicate that the FXIII-A Leu34 allele may contribute to a protective effect against the development of MI. There is a low prevalence of the Leu34 allele in Han Chinese compared to Caucasians.
Regaining control: a grounded theory of older adults with new-onset urinary incontinence

Rational for the study: Despite an extensive body of literature about urinary incontinence (UI), and it being a ‘hazard of hospitalization,’ no studies about new-onset UI from the perspectives of older adults were identified. Methodology: University and Hospital Institutional Review Boards approved this study. Data sources included: almost 170 hours from 61 field visits between December 2009 to May 2012, interviews with 14 participants, and their medical records. Grounded Theory methodology was followed (Glaser, 1978; 1992; 1998; 2002; Glaser & Strauss, 1967). Theoretical Findings: In sharing experiences with new-onset UI, the main concern of the participants, loss of control, emerged. Triggered by biological damage caused by illness or injury, the substantive theory of Regaining Control illuminates episodes of loss of bladder control as a part of a much broader concern: physical, spatial-temporal, and social aspects of loss of control. This complex, iterative and overlapping three-phase process Transferring Control, Exercising “Wobbly” Control, and Adjusting to Degree of Control Regained – describes and explains the behavioral patterns of how participants worked to resolve, or attempted to resolve, loss of control. Three conditions influence this process: biological recuperation, understandings of hospitals, and provisional controllers. Conclusion: Regaining Control contributes to the literature about UI, control, and patient-centered care. Findings provide
Specific aspects of modern life for people with multiple sclerosis: considerations for the practitioner

Multiple sclerosis (MS) is a chronic, debilitating, neurodegenerative disease that has a high impact on patients’ quality of life. Individuals are often diagnosed in early adulthood and are faced with the difficulty of managing their lifestyle within the context of this chronic illness. Here we review factors that influence the disease course and the challenges that might be encountered when managing patients with MS. The majority of diagnosed patients are women of childbearing age, making pregnancy-related issues a key concern. MS typically stabilizes during pregnancy and evidence suggests that the disease has no impact on the risk of complications or outcomes. However, the effect of disease-modifying therapies on outcomes is less clear, and discontinuation of treatment prior to pregnancy or when breastfeeding is recommended. Awareness of genetic risk factors is important for patients planning a family, as several genes increase the risk of MS. Further aspects that require consideration include infections, vaccinations, environmental factors, surgery and the emergence of osteoporosis. Vaccinations are generally not a risk factor for MS and may be beneficial in terms of protection against infection and reducing the number of relapses. Environmental factors such as vitamin D deficiency, low exposure to sunlight, smoking and Epstein−Barr virus infection can all negatively influence the disease course. Furthermore, osteoporosis is generally higher in patients with MS than the general population, and the risk is increased by the environmental and genetic factors associated with the disease; bone mineral density should be assessed and smoking cessation and correction of serum vitamin D levels are recommended. Finally, as patients with MS are typically young, they are at low risk of surgery-related complications, although they should be carefully monitored postoperatively. Awareness of, and planning around, these factors may minimize the impact of the disease on patients’ lifestyle.
Accuracy of computed tomographic features in differentiating intestinal tuberculosis from Crohn's disease: a systematic review with meta-analysis

Abdominal computed tomography (CT) can noninvasively image the entire gastrointestinal tract and assess extraintestinal features that are important in differentiating Crohn's disease (CD) and intestinal tuberculosis (ITB). The present meta-analysis pooled the results of all studies on the role of CT abdomen in differentiating between CD and ITB. We searched PubMed and Embase for all publications in English that analyzed the features differentiating between CD and ITB on abdominal CT. The features included comb sign, necrotic lymph nodes, asymmetric bowel wall thickening, skip lesions, fibrofatty proliferation, mural stratification, ileocaecal area, long segment, and left colonic involvements. Sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio (DOR) were calculated for all the features. Symmetric receiver operating characteristic curve was plotted for features present in >3 studies. Heterogeneity and publication bias was assessed and sensitivity analysis was performed by excluding studies that compared features on conventional abdominal CT instead of CT enterography (CTE). We included 6 studies (4 CTE, 1 conventional abdominal CT, and 1 CTE+conventional abdominal CT) involving 417 and 195 patients with CD and ITB, respectively. Necrotic lymph nodes had the highest diagnostic accuracy (sensitivity, 23%; specificity, 100%; DOR, 30.2) for ITB diagnosis, and comb sign (sensitivity, 82%; specificity, 81%; DOR, 21.5) followed by skip lesions (sensitivity, 86%; specificity, 74%; DOR, 16.5) had the highest diagnostic accuracy for CD diagnosis. On sensitivity analysis, the diagnostic accuracy of other features excluding asymmetric bowel wall thickening remained similar. Necrotic lymph nodes and comb sign on abdominal CT had the best diagnostic accuracy in differentiating CD and ITB.
Rethinking Composing in a Digital Age: Authoring Literate Identities Through Multimodal Storytelling

In this article, the authors engage the theoretical lens of multimodality in rethinking the practices and processes of composing in classrooms. Specifically, they focus on how learning new composing practices led some fifth-grade students to author new literate identities—what they call authorial stances—in their classroom community. Their analysis adds to the current research on the production and analysis of multimodal texts through an analysis of the interrelationships between multimodal composing processes and the development of literate identities. They found that by extending the composing process beyond print modalities students’ composing shifted in significant ways to reflect the circulating nature of literacies and texts and increased the modes of participation and engagement within the classroom curriculum.These findings are based on an ethnographic study of a multimodal storytelling project in a fifth-grade urban classroom.
Analysis and implications of changing hepatopancreatobiliary (HPB) case loads in general surgery residency training for HPB surgery accreditation.

OBJECTIVE This study was conducted to determine whether residents are receiving enough hepatopancreatobiliary (HPB) training during general surgery residencies to exclude the necessity of pursuing formal fellowships in HPB surgery. METHODS Trends in HPB surgery training were examined using Accreditation Council for Graduate Medical Education (ACGME) operative log data for the academic years 1999/2000 to 2009/2010. RESULTS Of 800,000 HPB operations performed annually in the USA, the proportion of HPB procedures performed by general surgery residents increased from 15% (122,007) to 18% (143,000) between the periods under study. Numbers of pancreatic, liver and biliary procedures performed by graduating general surgery residents increased by 47% (from 8185 to 12,006), 31% (from 7468 to 9765), and 14% (from 106,354 to 121,239), respectively. The mean number of operations undertaken by a graduating resident increased from 8.3 to 11.5 (38% increase) for pancreatic surgeries, from 7.6 to 9.4 (24% increase) for liver surgeries, and from 107.5 to 116.6 (8% increase) for biliary surgeries. Total numbers of complex pancreatic, liver and biliary procedures increased by 91% (from 4768 to 9129) and 24% (from 6649 to 8233), and decreased by 29% (from 6581 to 4648), respectively. CONCLUSIONS The overall trend shows an increase in the number of HPB procedures undertaken by graduating general surgery residents. The mean number of procedures exceeds ACGME requirements, but falls short of association guidelines. However, certain residents exceed International Hepato-Pancreato-Biliary Association (IHPBA) fellowship requirements for total and complex procedures during residency. Consideration should be given to those residents to allow them to bypass fellowship training provided that they meet other IHPBA standards.
Human Functioning and Social Justice

It will be seen how in place of the wealth and poverty of political economy come the rich human being and rich human need. The rich human being is simultaneously the human being in need of totality of human life-activities — the man in whom his own realization exists as an inner necessity, as need. Marx, Economic and Philosophical Manuscripts of 1844 Svetaketu abstained from food for fifteen days. Then he came to his father and said, `What shall I say? ' The father said: `Repeat the Rik, Yagus, and Saman verses. ' He replied, `They do not occur to me, Sir. ' The father said to him. `Go and eat! Then wilt thou understand me. ' Then Svetaketu ate, and afterwards approached his father. And whatever his father asked him, he knew it all by heart. After that, he understood what his father meant when he said: `Mind, my son, comes from food, breath from water, speech from fire. ' He understood what he said, yea, he understood it. Chandogya-Upanishad, VI Prapathaka, 7 Kanda When you love a man you want him to live and when you hate him you want him to die. If, having wanted him to live, you then want him to die, this is a misguided judgment. `If you did not do so for the sake of riches, you must have done so for the sake of novelty. ' Confucius, Analects, Book 12. 10
Temperature Sensitivity as a Microbial Trait Using Parameters from Macromolecular Rate Theory

The activity of soil microbial extracellular enzymes is strongly controlled by temperature, yet the degree to which temperature sensitivity varies by microbe and enzyme type is unclear. Such information would allow soil microbial enzymes to be incorporated in a traits-based framework to improve prediction of ecosystem response to global change. If temperature sensitivity varies for specific soil enzymes, then determining the underlying causes of variation in temperature sensitivity of these enzymes will provide fundamental insights for predicting nutrient dynamics belowground. In this study, we characterized how both microbial taxonomic variation as well as substrate type affects temperature sensitivity. We measured β-glucosidase, leucine aminopeptidase, and phosphatase activities at six temperatures: 4, 11, 25, 35, 45, and 60°C, for seven different soil microbial isolates. To calculate temperature sensitivity, we employed two models, Arrhenius, which predicts an exponential increase in reaction rate with temperature, and Macromolecular Rate Theory (MMRT), which predicts rate to peak and then decline as temperature increases. We found MMRT provided a more accurate fit and allowed for more nuanced interpretation of temperature sensitivity in all of the enzyme × isolate combinations tested. Our results revealed that both the enzyme type and soil isolate type explain variation in parameters associated with temperature sensitivity. Because we found temperature sensitivity to be an inherent and variable property of an enzyme, we argue that it can be incorporated as a microbial functional trait, but only when using the MMRT definition of temperature sensitivity. We show that the Arrhenius metrics of temperature sensitivity are overly sensitive to test conditions, with activation energy changing depending on the temperature range it was calculated within. Thus, we propose the use of the MMRT definition of temperature sensitivity for accurate interpretation of temperature sensitivity of soil microbial enzymes.
Asymptotic normality of linear multiuser receiver outputs

This paper proves large-system asymptotic normality of the output of a family of linear multiuser receivers that can be arbitrarily well approximated by polynomial receivers. This family of receivers encompasses the single-user matched filter, the decorrelator, the minimum mean square error (MMSE) receiver, the parallel interference cancelers, and many other linear receivers of interest. Both with and without the assumption of perfect power control, we show that the output decision statistic for each user converges to a Gaussian random variable in distribution as the number of users and the spreading factor both tend to infinity with their ratio fixed. Analysis reveals that the distribution conditioned on almost all spreading sequences converges to the same distribution, which is also the unconditional distribution. This normality principle allows the system performance, e.g., the multiuser efficiency, to be completely determined by the output signal-to-interference ratio (SIR) for large linear systems.
Scaffolding and Artifacts

Following SCT, the present study aimed at examining the contribution of scaffolding and artifacts in improving EFL learners' assessment literacy. The study utilized a pretest-posttest control and experimental group design. Using an Oxford Placement Test, 60 EFL seniors were assigned to experimental (n=30) and control (n=30) groups. For the experimental group, five sessions of meditational practices were predicted. Each session included two phases. A discussion phase, which embraced some technical information related to language testing in general and an assessment phase. During the former, participants were instructed to carry out different tasks assisted by their teacher and peers and referring to the internet. For assessment tasks, they were directed to collaboratively assess their friends' oral productions based on idea units. Besides posttest, the experimental group had two extra sets of scores: Oral presentation I and II as well as assessment literacy I and II. They received I test of each pair before the mediation and the II after the mediation. A comparison of control and experimental groups' pretest and posttest data, comparisons of experimental group's first and second presentation as well as the first and the second set of Assessment Literacy Scores provide information about the effects of assessment literacy on learning.
Association between the C.1161G>A and C.1779C>G Genetic Variants of XRCC1 Gene and Hepatocellular Carcinoma Risk in Chinese Population

The human X-ray repair complementing group 1 gene (XRCC1) is an important candidate gene influencing hepatocellular carcinoma (HCC) susceptibility. The objective of this study was to detect the association between c.1161G>A and c.1779C>G variants of XRCC1 gene and HCC risk. This study was conducted in Chinese population consisting of 623 HCC cases and 639 controls. These two genetic variants could be genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The association of XRCC1 gene variants with the risk of HCC was investigated under different genetic models. Our findings suggested that the genotypes/alleles from c.1161G>A and c.1779C>G genetic variants were statistically associated with HCC risk. As for the c.1161G>A, the AA genotype was statistically associated with the increased risk of HCC compared to GG wild genotype (OR = 2.36, 95% CI 1.63-3.40, P < 0.001). As for the c.1779C>G, the risk of HCC was significantly higher for GG genotype compared to CC wild genotype (OR = 2.17, 95% CI 1.51-3.12, P < 0.001). Furthermore, significant differences in the risk of HCC were also detected in other genetic models for these two variants. The allele-A of c.1161G>A and allele-G of c.1779C>G variants may contribute to the susceptibility of HCC (A versus G: OR = 1.48, 95% CI 1.26-1.75, P < 0.001 and G versus C: OR = 1.51, 95% CI 1.28-1.78, P < 0.001). Our data indicated that these two variants of XRCC1 gene were statistically associated with HCC risk in Chinese population.