Miracle-dz/UniFAR-FTUs huggingface dataset:
Cytomorphological correlates of epidermal growth factor receptor mutations in lung carcinoma

The initial diagnosis of lung carcinoma is frequently made by fine‐needle aspiration biopsy. Novel therapeutic strategies of this disease include tyrosine kinase inhibitors (TKI), such as gefitinib (Iressa®) or erlotinib (Tarceva®), which target the kinase domain of epidermal growth factor receptor (EGFR). Somatic mutations of this region have been shown to predict a therapeutic response of lung carcinomas to TKI. EGFR mutations have been described in adenocarcinomas of the lung, especially the bronchioloalveolar subtype, which has both cytopathologic and histopathologic definitions. This study investigates whether tumors with EGFR mutations display a characteristic phenotype on fine‐needle aspiration biopsy. We identified 37 fine‐needle aspiration biopsy of lung masses on which molecular analysis for EGFR mutations was available. Molecular analysis was performed on DNA isolated from formalin‐fixed, paraffin‐embedded, or frozen tissue from the corresponding core biopsies/cell blocks or resection specimens followed by PCR with primers for the tyrosine kinase region exons 18–24 and nucleotide sequence analysis by gel electrophoresis. Two observers who were blinded to the mutational data assessed several cytomorphological parameters. A semiquantitative analysis included predominant tissue pattern (flat or overlapping), nuclear features (nucleoli, intranuclear inclusions, grooves), cytoplasmic qualities, and extracellular material. All cases were adenocarcinomas primary in the lung. Thirteen cases showed EGFR mutations in exons 18, 19, 20, or 21 of the tyrosine kinase domain. The 24 cases negative for the relevant mutation served as the control group. Tumors with EGFR mutations were statistically more likely to demonstrate a predominantly flat, monolayer architecture (P = 0.04) with nuclear inclusions (P = 0.014) and the absence of macronucleoli (P = 0.001). The predominance of flat monolayers in conjunction with the absence of extracellular mucin and macronucleoli indicated the presence of EGFR mutations with a positive predictive value of 69% and a negative predictive value of 92%. All four cases with extracellular mucin were negative for the examined mutations. Some of the traditional cytomorphological features of bronchioloalveolar carcinoma, i.e., flat monolayers, intranuclear inclusions, and the absence of macronucleoli, statistically correlated with the presence of mutations within the tyrosine kinase region of EGFR. Cytomorphological features could serve as an adjunctive predictive marker of response to TKIs and possibly to other new therapies in development. Diagn. Cytopathol. 2007;35:257–262. © 2007 Wiley‐Liss, Inc.
When an Arrest Is Not an Arrest

The authors examine a largely unexamined issue: the extent to which, and circumstances under which, police exceptionally clear cases. This is a particularly salient issue in intimate partner violence cases where this clearance category may be used to enable the circumvention of laws mandating arrest. Using NIBRS data to compare the police response to different victim-offender relationship categories, the authors examine the extent of, and circumstances under which, police officers exceptionally clear cases and whether evidence exists suggesting that the exceptional clearance category is used to circumvent mandatory arrest laws. They conclude by discussing the policy implications of the findings.
Homology Groups of Types in Model Theory and the Computation of H 2(p)

Abstract We present definitions of homology groups Hn (p), n ≥ 0, associated to a complete type p. We show that if the generalized amalgamation properties hold, then the homology groups are trivial. We compute the group H 2(p) for strong types in stable theories and show that any profinite abelian group can occur as the group H 2 (p).
Matthew Effects in Reading: Some Consequences of Individual Differences in the Acquisition of Literacy

A framework for conceptualizing the development of individual differences in reading ability is presented that synthesizes a great deal of the research literature. The framework places special emphasis on the effects of reading on cognitive development and on “bootstrapping” relationships involving reading. Of key importance are the concepts of reciprocal relationships—situations where the causal connection between reading ability and the efficiency of a cognitive process is bidirectional-and organism-environment correlation—the fact that differentially advantaged organisms are exposed to nonrandom distributions of environmental quality. Hypotheses are advanced to explain how these mechanisms operate to create rich-get-richer and poor-get-poorer patterns of reading achievement. The framework is used to explicate some persisting problems in the literature on reading disability and to conceptualize remediation efforts in reading.
Black under‐participation in wildland recreation: Alternative explanations

Two alternative perspectives on Black underparticipation in wildland recreation are discussed: (1) marginality (that underparticipation results from preventive factors such as poverty and discrimination), and (2) ethnicity (that recreational patterns are based on subcultural leisure norms and value systems). Data from a 1969 survey of urban California Blacks and whites cast doubt on marginality as an explanation; ethnicity as an alternative explanation should be explored, in that differences could result from leisure style and those normative restraints within the Black community that temper leisure choices.
Markedness, Discoursal Modes, and Relative Clause Formation in a Formal and an Informal Context

Typological markedness has been suggested as a possible explanation or a means of predicting the development of Interlanguage (IL) syntax (Eckman, 1977; Hyltenstam, 1978, 1984; Rutherford, 1982). More specifically, the Accessibility Hierarchy (AH) (Keenan & Comrie, 1977, 1979) has been used to predict the acquisitional order of relative clauses in a second language (Hyltenstam, 1984). No research, however, has been conducted to investigate the possible influence of learning context on relative clause (RC) formation. In this study, English relative clauses were elicited from two groups of Italian learners. The first group was composed of 48 formal learners and the second group of 38 informal learners. It was hypothesized that the order as predicted by the AH would be yielded by both groups with the formal group's IL exhibiting more marked structures than the informal group's. The type of discourse—planned versus unplanned—to which learners were mostly exposed was thought to have an effect on the level of linguistic elaboration achieved.
Repairing Reed-Solomon Codes With Multiple Erasures

Despite their exceptional error-correcting properties, Reed–Solomon (RS) codes have been overlooked in distributed storage applications due to the common belief that they have poor repair bandwidth. A naive repair approach would require for the whole file to be reconstructed in order to recover a single erased codeword symbol. In a recent work, Guruswami and Wootters (STOC’16) proposed a single erasure repair method for RS codes that achieves the optimal repair bandwidth amongst all linear encoding schemes. Their key idea is to recover the erased symbol by collecting a sufficiently large number of its traces, each of which can be constructed from a number of traces of other symbols. We extend the trace collection technique to cope with two and three erasures.
Light and Electron Microscopy of the Bulbus arteriosus of the European Eel (Anguilla anguilla)

The bulbus arteriosus of teleost fish acts as an elastic reservoir that dilates during ventricular systole to store a large part of the cardiac stroke volume. Despite its functional importance, the knowledge of the structure of the bulbus wall is still fragmentary. We have undertaken a series of studies in order to establish a general morphological plan of the teleost bulbus. The bulbus arteriosus of the European eel is studied here by means of conventional light, and transmission and scanning electron microscopy. The inner surface of the bulbus wall is irregular due to the presence of branching ridges that flatten and disappear toward the ventral aorta. The ridge surface is covered by flattened endocardial cells that show moderately dense bodies. In the ridge tissue, cells near the endocardium are mostly undifferentiated and appear isolated in a loose filamentous matrix. Ridge cells progressively cluster toward the middle layer, become surrounded by a dense matrix, and adopt characteristics typical of smooth muscle cells. This suggests the existence of a differentiation gradient. The middle layer is formed by typical smooth muscle cells embedded in a meshwork matrix that contains thin and thick filaments. Stretching of this meshwork suggests an active role of smooth muscle cells in bulbus wall dynamics. Furthermore, large areas of the extracellular space are occupied by elastin-like material. The amount of this material decreases toward the external layer. Collagen is demonstrated across the entire thickness of the bulbus wall, its amount and organization increasing from the inner toward the outer bulbus surface. The existence of matrix gradients should progressively increase wall strength, maintaining bulbus dilation within safe physiological parameters. The epicardium is formed by flattened cells that contain numerous pinocytotic vesicles, suggesting an active interchange of solutes with the pericardial cavity.
An advanced NLP framework for high-quality Text-to-Speech synthesis

In order to build a TTS (Text-to-Speech) synthesis system one must provide two key components: a NLP (Natural Language Processing) stage, which essentially operates on the input text, and a speech generation stage to produce the desired output. These two distinct levels must exchange both data and commands to produce intelligible and natural speech. As the complete TTS task relies on many distinct scientific areas, any achievement toward standardization can minimize the effort and increase the dynamic of the results. This paper gives an overview of the NLP stage in the TTS system for Romanian language built by our collective, and describes the integration into the system of SSML (Speech Synthesis Markup Language), as a nowadays well recognized standard for TTS document authoring and inter-modules communication.
Endothelin-mediated gut microcirculatory dysfunction during porcine endotoxaemia.

BACKGROUND The potent vasoconstrictor endothelin-1 has been implicated in the pathogenesis of the microcirculatory dysfunction seen in sepsis. The mixed endothelin receptor antagonist tezosentan and the selective endothelin A-receptor antagonist TBC3711 were used to investigate the importance of the different endothelin receptors in modulating splanchnic regional blood flow and microvascular blood flow in endotoxaemia. METHODS Eighteen anaesthetized pigs were i.v. infused with endotoxin (Escherichia coli lipopolysaccharide, serotype 0111:b4) for 300 min. After 120 min, six animals received tezosentan and six animals received TBC3711. Six animals served as endotoxin-treated controls. Laser Doppler flowmetry was used to measure microcirculatory blood flow in the liver and ileum. Superior mesenteric artery flow (SMA(FI)) and portal vein flow (PV(FI)) were measured with ultrasonic flow probes, and air tonometry was used to measure Pco₂ in the ileal mucosa. RESULTS TBC3711 did not improve splanchnic regional blood flow or splanchnic microvascular blood flow compared with endotoxin-treated controls. Tezosentan increased PV(FI) (P<0.05), but SMA(FI) was not improved compared with the other groups. In the tezosentan group, microvascular blood flow in the ileal mucosa (MCQ(muc)) improved and mucosal-arterial Pco₂ gap decreased (P<0.05 for both) compared with endotoxin-treated controls and the TBC3711 group. CONCLUSIONS Tezosentan improved MCQ(muc) without any concomitant increase in SMA(FI), implying a direct positive effect on the microcirculation. TBC3711 was not effective in improving regional splanchnic blood flow or splanchnic microvascular blood flow. Dual endothelin receptor antagonism was necessary to improve MCQ(muc), indicating a role for the endothelin B-receptor in mediating the microcirculatory failure in the ileal mucosa.
Posted Warnings, Compliance, and Behavioral Intent

The purpose of this study was to examine behavioral compliance with posted warnings varying in design features. Thirty-seven participants performed a chemical mixing task in an environment with no posted warning, a text-only warning, or a warning consisting of design components identified in the warnings literature (i.e., signal word, alert symbol, color). Participants were randomly assigned to one of three direct experience sign conditions. Participants also provided ratings of behavioral intent in conditions involving written scenarios and photographs of the task setting. Although eleven of the participants wore either gloves or goggles or both, none of the participants in the sign conditions looked at the posted warning signs. Ratings of behavioral intent in response to written scenarios revealed significant effects of sign type, and significant differences between ratings of self and ratings of others. Factors relating to research design and sample selection as well as implications for future compliance research are discussed.
Improvement of cardiac neuronal function after carvedilol treatment in dilated cardiomyopathy: a 123I-MIBG scintigraphic study.

UNLABELLED Carvedilol can induce important clinical and hemodynamic improvements in patients with chronic heart failure resulting from severe left ventricular (LV) dysfunction. This study examines the impact of carvedilol on cardiac neuronal function using 123I-metaiodobenzylguanidine (MIBG) scintigraphy in dilated cardiomyopathy. METHODS Twenty-two patients with chronic heart failure (19 men, 3 women; mean age, 54 y; age range, 34-64 y) assessed as New York Hospital Association (NYHA) class II or III and with initial resting radionuclide LV ejection fractions (LVEF) < 0.40 were enrolled in the study. Patients had long histories of symptomatic LV dysfunction despite optimal diuretics and angiotensin-converting enzyme inhibitor treatment. Over a 6-mo period, 50 mg/day carvedilol was administered to these patients. Planar 123I-MIBG scintigraphy provided measurements of cardiac neuronal uptake (as heart-to-mediastinum count activity ratio [HMR]), 4h after intravenous injection of 185 MBq MIBG. Hemodynamic, clinical, radionuclide LVEF and HMR data measured at the outset and after 6 mo of carvedilol were compared. RESULTS Resting heart rate decreased from 81 +/- 13 to 71 +/- 9 bpm (P = 0.003). After carvedilol therapy NYHA functional classification for these patients improved from 2.6 +/- 0.5 to 2.3 +/-0.5 (P = 0.04), LVEF improved from 22% +/- 9% to 30% +/- 13% (P = 0.005), and HMR improved from 145% +/- 23% to 170% +/- 25% (P = 0.0001). CONCLUSION Carvedilol induces improvements of clinical symptoms and cardiac neuronal and systolic functions in patients with dilated cardiomyopathy and chronic optimal treatment.
Comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical HIV practice

Abstract We determined risk of virologic failure (VF) in individuals initiating tenofovir/emtricitabine/efavirenz as single versus multiple tablet regimens (MTR). We found no significant difference in the risk of VF, though did observe a trend toward more VF and M184 V mutations among persons initiating MTR. Temporal trends in care may have confounded results.
A Complex Case: Using the case study method to explore uncertainty and ambiguity in undergraduate business education

The case method is a definitive and foundational technology in business education. It was first developed as a vocational training tool equipping students for future employment. In this conception, the organisation was seen as a machine, and managers as the engineers who would maintain it through planned interventions. The case method allowed aspiring managers to practise intervention skills in a safe environment. Since the origins of the case method in US business schools before the First World War, conceptions of organisations have moved on. They are no longer seen as machine-like, but as complex, ambiguous, and protean. The 'wicked' problems that potential managers will face in an uncertain world require the development of critical thinking and sensemaking abilities. While the traditional approach to the case continues, its use as a vehicle to explore and manage complexity and ambiguity is emerging, although this is facing resistance from some students and staff.
LINGO, an Efficient Holographic Text Based Method To Calculate Biophysical Properties and Intermolecular Similarities

SMILES strings are the most compact text based molecular representations. Implicitly they contain the information needed to compute all kinds of molecular structures and, thus, molecular properties derived from these structures. We show that this implicit information can be accessed directly at SMILES string level without the need to apply explicit time-consuming conversion of the SMILES strings into molecular graphs or 3D structures with subsequent 2D or 3D QSPR calculations. Our method is based on the fragmentation of SMILES strings into overlapping substrings of a defined size that we call LINGOs. The integral set of LINGOs derived from a given SMILES string, the LINGO profile, is a hologram of the SMILES representation of the molecule described. LINGO profiles provide input for QSPR models and the calculation of intermolecular similarities at very low computational cost. The octanol/water partition coefficient (LlogP) QSPR model achieved a correlation coefficient R2=0.93, a root-mean-square error RRMS=0.49 log units, a goodness of prediction correlation coefficient Q2=0.89 and a QRMS=0.61 log units. The intrinsic aqueous solubility (LlogS) QSPR model achieved correlation coefficient values of R2=0.91, Q2=0.82, and RRMS=0.60 and QRMS=0.89 log units. Integral Tanimoto coefficients computed from LINGO profiles provided sharp discrimination between random and bioisoster pairs extracted from Accelrys Bioster Database. Average similarities (LINGOsim) were 0.07 for the random pairs and 0.36 for the bioisosteric pairs.
Service Quality: The Key Role of Service Climate and Service Behavior of Boundary Employee Units

This study simultaneously tests the influence of two resources that boundary employee units can use to improve service quality. The first is the boundary employee units’ perceptions of organizational values oriented toward creating a good service climate. The second is the boundary employees’ competences oriented to providing the service, that is, their own service behavior during service transactions. Moreover, organizational climate and organizational facilitators are also analyzed as antecedents of the two resources. The sample consisted of 117 boundary employee units aggregated from 349 boundary employees and 1,157 customers. Structural Equation Modeling analysis confirmed that service quality perceived by customers can be predicted by both service climate and service behavior perceived by boundary employee units. Moreover, organizational facilitators and organizational climate are significant antecedents for higher levels of service climate. Therefore, results confirm the importance of both roles in improving customer perceptions of service quality.
Ketamine, Phencyclidine, and MK‐801 Protect Against Kainic Acid‐Induced Seizure‐Related Brain Damage

Summary: Recent evidence implicates the endogenous excitotoxin, glutamate (Glu), in several neurologic disorders, including seizure‐related brain damage. Ketamine, phencyclidine, and MK‐801, which are noncompetitive antagonists of the N‐methyl‐D‐aspartate (NMDA) subtype of Glu receptor (but do not antagonize kainic acid receptors) were tested in the present study for their effects on behavioral and/or electrographic seizures and seizure‐related brain damage induced by kainic acid. Behavioral seizure activity was reduced by these agents, as was spread of electrographic seizures to neocortex, but seizures recorded from deep brain regions such as hippocampus, piriform cortex, and amygdala were not significantly diminished. All three agents prevented seizure‐related brain damage in the amygdala, piriform cortex, thalamus, and CA1 region of the hippocampus but conferred little or no protection in the lateral septum and CA3 region of the hippocampus. The regional selectivity of the neuroprotective effect suggests that NMDA receptors may play a more dominant role in seizure‐related brain damage in some brain regions than in others. The ability of NMDA antagonists to prevent seizure‐related damage in several brain regions without suppressing seizure activity suggests that in these brain regions persistent seizure activity can be maintained by other transmitter systems, with or without NMDA receptor participation, but that seizure‐related brain damage is critically dependent on NMDA receptor participation.
Understanding Organizational Evolution: Toward a Research Agenda using Generalized Darwinism

The terms ‘evolution’ and ‘coevolution’ are widely used in organization studies but rarely defined. Often it is unclear whether they refer to single entities or populations. When specific evolutionary processes are suggested, the labelling is often misleading. For example, in the debate over the roles of individual adaptation and competitive selection, the ‘selectionist’ position of Michael Hannan and John Freeman, which emphasizes the role of selection and stress the limits of individual firm adaptability, is often described as ‘Darwinian’ whereas opposing views that emphasize adaptability are described as ‘Lamarckian’. But these labels are not strictly dichotomous. Scholars have shown that core Darwinian principles, resulting from abstract ontological communality rather than analogy, apply to social evolution. This opens up a research agenda using the principles of generalized Darwinism and the replicator–interactor framework to help understand the evolution of organizations. Some illustrations of the conceptual value of this approach are provided, including understanding the entwinement of selection and adaptation, the nature and role of organizational routines, the place of strategic choice and the growth of organizational complexity. The framework of generalized Darwinism also helps to bridge apparently divergent perspectives in the business strategy and organizational ecology literatures.
Strategies for Enhancing Student Interactivity in an Online Environment

Abstract. The number of online courses being offered by postsecondary institutions has increased dramatically and consequently an increasing number of faculty are faced with teaching online courses. Students demonstrate more positive attitudes and higher levels of performance when online classes are highly interactive, but many faculty about to embark in online teaching are not aware of the techniques available to increase the level of interactivity in online courses. This article describes how to establish an interactive online learning environment and provides strategies for increasing student interactivity.