Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential susceptibility of isolated mouse retinal neurons and photoreceptors to kainic acid toxicity. In vitro studies.

Dissociated cultures of mouse retinal neurons and photoreceptors in chemically defined medium were used to investigate the susceptibility of these cells to the neurotoxin kainic acid (KA). Cells isolated from the newborn mouse retina were initially insensitive to this toxin, and the cells that differentiated as rod photoreceptors retained this resistance throughout the culture period. However, amacrine neurons became increasingly sensitive to KA toxicity as they differentiated in culture; after the fifth day in vitro approximately 90% of these cells were killed by KA in a concentration- and time-dependent fashion. The neurons showed pronounced swelling within 10 min of treatment onset, and cell lysis and nuclear fragmentation were evident during the next few hours. KA-induced degeneration of these neurons was corroborated using the amacrine cell-specific monoclonal antibody HPC-1, as well as autoradiographic and biochemical determinations of the high affinity uptake for GABA. This inhibitory neurotransmitter was taken up by amacrine neurons but not by photoreceptor cells, and this uptake was completely abolished in KA-treated cultures. Similar results were obtained with the neuronal enzyme choline acetyltransferase. However, both photoreceptor survival and the expression of photoreceptor markers such as opsin and the retinoid-binding protein interphotoreceptor (IRBP) were similar in KA-treated and control cultures. Similarly, the high affinity uptake of glutamate, an excitatory amino acid which is predominantly taken up by photoreceptors, showed only modest changes in KA-treated cultures. (ABSTRACT TRUNCATED AT 250 WORDS)
Cost analysis of hash collisions : will quantum computers make SHARCS obsolete?

Current proposals for special-purpose factorization hardware will become obsolete if large quantum computers are built: the number-field sieve scales much more poorly than Shor's quantum algorithm for factorization. Will all special-purpose cryptanalytic hardware become obsolete in a post-quantum world? A quantum algorithm by Brassard, HOyer, and Tapp has frequently been claimed to reduce the cost of b-bit hash collisions from 2^b/2 to 2^b/3. This paper analyzes the Brassard-HOyer-Tapp algorithm and shows that it has fundamentally worse price-performance ratio than the classical van Oorschot-Wiener hash-collision circuits, even under optimistic assumptions regarding the speed of quantum computers.
Diagnosis of polycystic ovary syndrome (PCOS): revisiting the threshold values of follicle count on ultrasound and of the serum AMH level for the definition of polycystic ovaries.

BACKGROUND Polycystic ovarian morphology (PCOM) at ultrasound is currently used in the diagnosis of polycystic ovary syndrome (PCOS). We hypothesized that the previously proposed threshold value of 12 as an excessive number of follicles per ovary (FN) is no longer appropriate because of current technological developments. In this study, we have revisited the thresholds for FN and for the serum Anti-Müllerian hormone (AMH) level (a possible surrogate for FN) for the definition of PCOM. METHODS Clinical, hormonal and ultrasound data were consecutively recorded in 240 patients referred to our department between 2008 and 2010 for exploration of hyperandrogenism (HA), menstrual disorders and/or infertility. RESULTS According to only their symptoms, patients were grouped as: non-PCOS without HA and with ovulatory cycles (group 1, n = 105), presumption of PCOS with only HA or only oligo-anovulation (group 2, n = 73) and PCOS with HA and oligo-anovulation (group 3, n = 62). By cluster analysis using androgens, LH, FSH, AMH, FN and ovarian volume, group 1 appeared to be constituted of two homogeneous clusters, most likely a non-PCOM non-PCOS subgroup (n = 66) and a PCOM, non-PCOS (i.e. asymptomatic) subgroup (n = 39). Receiver operating characteristic curve analysis was applied to distinguish the non-PCOM non-PCO members of group 1 and to group 3. For FN and serum AMH respectively, the areas under the curve were 0.949 and 0.973 and the best compromise between sensitivity (81 and 92%) and specificity (92 and 97%) was obtained with a threshold values of 19 follicles and 35 pmol/l (5 ng/ml). CONCLUSIONS For the definition of PCOM, the former threshold of >12 for FN is no longer valid. A serum AMH >35 pmol/l (or >5 ng/ml) appears to be more sensitive and specific than a FN >19 and should be therefore included in the current diagnostic classifications for PCOS.
Accuracy of Intraoperative Computed Tomography during Deep Brain Stimulation Procedures: Comparison with Postoperative Magnetic Resonance Imaging

Objective: To determine the accuracy of intraoperative computed tomography (iCT) in localizing deep brain stimulation (DBS) electrodes by comparing this modality with postoperative magnetic resonance imaging (MRI). Background: Optimal lead placement is a critical factor for the outcome of DBS procedures and preferably confirmed during surgery. iCT offers 3-dimensional verification of both microelectrode and lead location during DBS surgery. However, accurate electrode representation on iCT has not been extensively studied. Methods: DBS surgery was performed using the Leksell stereotactic G frame. Stereotactic coordinates of 52 DBS leads were determined on both iCT and postoperative MRI and compared with intended final target coordinates. The resulting absolute differences in X (medial-lateral), Y (anterior-posterior), and Z (dorsal-ventral) coordinates (ΔX, ΔY, and ΔZ) for both modalities were then used to calculate the euclidean distance. Results: Euclidean distances were 2.7 ± 1.1 and 2.5 ± 1.2 mm for MRI and iCT, respectively (p = 0.2). Conclusion: Postoperative MRI and iCT show equivalent DBS lead representation. Intraoperative localization of both microelectrode and DBS lead in stereotactic space enables direct adjustments. Verification of lead placement with postoperative MRI, considered to be the gold standard, is unnecessary.
Infinite Edge Partition Models for Overlapping Community Detection and Link Prediction

A hierarchical gamma process infinite edge partition model is proposed to factorize the binary adjacency matrix of an unweighted undirected relational network under a Bernoulli-Poisson link. The model describes both homophily and stochastic equivalence, and is scalable to big sparse networks by focusing its computation on pairs of linked nodes. It can not only discover overlapping communities and inter-community interactions, but also predict missing edges. A simplified version omitting inter-community interactions is also provided and we reveal its interesting connections to existing models. The number of communities is automatically inferred in a nonparametric Bayesian manner, and efficient inference via Gibbs sampling is derived using novel data augmentation techniques. Experimental results on four real networks demonstrate the models' scalability and state-of-the-art performance.
Convergence of Self-Organizing Pulse-Coupled Oscillator Synchronization in Dynamic Networks

The theory of pulse-coupled oscillators provides a framework to formulate and develop self-organizing synchronization strategies for wireless communications and mobile computing. These strategies show low complexity and are adaptive to changes in the network. Even though several protocols have been proposed and theoretical insight was gained there is no proof that guarantees synchronization of the oscillator phases in general dynamic coupling topologies under technological constraints. Here, we introduce a family of coupling strategies for pulse-coupled oscillators and prove that synchronization emerges for systems with arbitrary connected and dynamic topologies, individually changing signal propagation and processing delays, and stochastic pulse emission. It is shown by simulations how unreliable links or intentionally incomplete communication between oscillators can improve synchronization performance.
An Adaptive Controller for Two Cooperating Flexible Manipulators

The control problem for two serial flexible multilink robots which carry a common rigid payload is considered. An adaptive controller with feedback and feedforward elements is presented which can track a prescribed trajectory for the payload with simultaneous vibration suppression when the manipulated payload is sufficiently large. A free load-sharing parameter appears in the passivity-based control law which allows the torque requirement to be shared between the two arms in a largely arbitrary fashion. Simulation results using a complex model are given which demonstrate excellent tracking performance in the face of complete payload uncertainty. © 2003 Wiley Periodicals, Inc.
Tobacco Smoke Exposure in Pulmonary Arterial and Thromboembolic Pulmonary Hypertension

Background: Animal studies and data from a single-center study suggest that tobacco smoke exposure may be a risk factor for precapillary pulmonary hypertension (PH). Objective: We aimed to survey tobacco smoke exposure in a large PH collective and to compare it with epidemiological data from healthy subjects. Methods: This is an international, multicenter, case-control study including patients with pulmonary arterial and chronic thromboembolic PH. All patients were asked specific questions about tobacco smoke exposure. Healthy controls were retrieved from the Swiss Health Survey (n = 18,747). Results: Overall (n = 472), 49% of PH patients were smokers and there was a clear sex difference (women 37%, men 71%). Significantly more PH men were smokers compared with healthy controls, whereas less PH women were ever active smokers. However, 50% of the non-smoking PH women were exposed to secondhand smoke, leading to a significantly higher number of tobacco smoke-exposed individuals compared to healthy controls. PH smokers were significantly younger compared to those not exposed. Conclusion: Active and environmental tobacco smoke exposure is common in PH. The higher prevalence of male PH smokers, the higher exposure to environmental tobacco smoke in PH women compared to healthy controls and the lower age at PH diagnosis in smokers may indicate a pathogenic role of tobacco smoke exposure in PH.
The Redshift Distribution and Luminosity Functions of Galaxies in the Hubble Deep Field

Photometric redshifts have been determined for the galaxies in the Hubble Deep Field. The resulting redshift distribution shows two peaks: one at z ~ 0.6 and one at z ~ 2.2. Luminosity functions derived from the redshifts show strong luminosity evolution as a function of redshift. This evolution is consistent with the Babul & Rees scenario wherein massive galaxies form stars at high redshift while star formation in dwarf galaxies is delayed until after z = 1.
Wool Keratin-Associated Protein Genes in Sheep—A Review

The importance of sheep’s wool in making textiles has inspired extensive research into its structure and the underlying genetics since the 1960s. Wool keratin-associated proteins (KAPs) are a key structural component of the wool fibre. The characterisation of the genes encoding these proteins has progressed rapidly with advances in the nucleotide and protein sequencing. This review describes our knowledge of ovine KAPs, their categorisation into families, polymorphism in the proteins and genes, the clustering and chromosomal location of the genes, some characteristics of gene expression and some potential effects of the KAPs on wool traits. The extent and nature of genetic variation in wool KAP genes and its association with fibre characteristics, provides an opportunity for the development of gene-markers for selective breeding of sheep to produce better wool with properties highly matched to specific end-uses.
Lithospheric flexural modelling of the seaward and trenchward of the subducting oceanic plates

ABSTRACT Based on a two-segment plate flexural modelling, we investigated the effective elastic thickness of global subducting oceanic lithosphere. Our results show that for the plate age of 0 to 50 Ma, the seaward effective elastic thickness TeM values are located between 600 and 900°C isotherms, and do not track any isotherm, while the majority of the trenchward effective elastic thickness Tem values are located between 300 and 600°C isotherms. For the plate age older than 50 Ma, TeM values basically matches the 600°C isotherm with some fluctuations for the age older than 110 Ma, while Tem values mainly fall between 200 and 400°C isotherms. The reduction in effective elastic thickness (TeM-Tem) varies from 2.6 to 30.1 km, or 11–68% of seaward TeM. Thus, the absolute value of the decrease in the effective elastic thicknesses (TeM-Tem) increases with the plate age, while the percentage reduction in the effective elastic thickness (1-Tem/TeM) has no obvious relationship with the age, but more related to the curvature of bending plate. Almost all bending-related earthquakes occurred above the TeM line, but many normal-faulting earthquakes are deeper than the TeM-Tem line, implying that the plate may still retain some thickness of an elastic property core in the areas (depth) where earthquakes occur.
Timing and Tuning for Familiarity of Cortical Responses to Faces

Different kinds of known faces activate brain areas to dissimilar degrees. However, the tuning to type of knowledge, and the temporal course of activation, of each area have not been well characterized. Here we measured, with functional magnetic resonance imaging, brain activity elicited by unfamiliar, visually familiar, and personally-familiar faces. We assessed response amplitude and duration using flexible hemodynamic response functions, as well as the tuning to face type, of regions within the face processing system. Core face processing areas (occipital and fusiform face areas) responded to all types of faces with only small differences in amplitude and duration. In contrast, most areas of the extended face processing system (medial orbito-frontal, anterior and posterior cingulate) had weak responses to unfamiliar and visually-familiar faces, but were highly tuned and exhibited prolonged responses to personally-familiar faces. This indicates that the neural processing of different types of familiar faces not only differs in degree, but is probably mediated by qualitatively distinct mechanisms.
Age and fertility: can women wait until their early thirties to try for a first birth?

Postponing the start of childbearing raises the question of fertility postponed versus fertility foregone. One of the limitations of previous studies of 'How late can you wait? ' is that any observed decline in the probability of conception with age could be due to a decline in fecundability with age or due to a decline in coital frequency with age or due to both factors. Using data from a multinational longitudinal study conducted to determine the daily probability of conception among healthy subjects, a discrete-time event history model with long-term survivors (sterile population) is used to study the relationship between age and fecundability for childless women, while controlling for the pattern of intercourse within a menstrual cycle. The findings suggest that women can wait until their early thirties to try for a first birth, providing that they are not already sterile, as the magnitude of the decline in fecundability is very modest and of little practical importance.
Systemic and Neuropathologic Effects of E. coli Endotoxin in Neonatal Dogs

Summary: The acute systemic and neuropathologic effects of E. coli endotoxin were determined in neonatal dogs. Administration of sublethal (LD0), moderate (LD50), or lethal (LD100) doses of endotoxin produced significant arterial hypotension, metabolic (lactic) acidosis, and hypoglycemia. Neuropathologic changes consisted of widespread inflammation in both grey and white matter; however, necrotic lesions were found only in forebrain white matter.
Exploiting compressed block size as an indicator of future reuse

We introduce a set of new Compression-Aware Management Policies (CAMP) for on-chip caches that employ data compression. Our management policies are based on two key ideas. First, we show that it is possible to build a more efficient management policy for compressed caches if the compressed block size is directly used in calculating the value (importance) of a block to the cache. This leads to Minimal-Value Eviction (MVE), a policy that evicts the cache blocks with the least value, based on both the size and the expected future reuse. Second, we show that, in some cases, compressed block size can be used as an efficient indicator of the future reuse of a cache block. We use this idea to build a new insertion policy called Size-based Insertion Policy (SIP) that dynamically prioritizes cache blocks using their compressed size as an indicator. We compare CAMP (and its global variant G-CAMP) to prior on-chip cache management policies (both size-oblivious and size-aware) and find that our mechanisms are more effective in using compressed block size as an extra dimension in cache management decisions. Our results show that the proposed management policies (i) decrease off-chip bandwidth consumption (by 8.7% in single-core), (ii) decrease memory subsystem energy consumption (by 7.2% in single-core) for memory intensive workloads compared to the best prior mechanism, and (iii) improve performance (by 4.9%/9.0%/10.2% on average in single-/two-/four-core workload evaluations and up to 20.1%) CAMP is effective for a variety of compression algorithms and different cache designs with local and global replacement strategies.
Marginally monotonic maintenance policies for a multi-state deteriorating machine with probabilistic monitoring, and silent failures

We characterize the structure of optimal policies for maintenance & replacement actions over a finite horizon. The context is machine monitoring when the following are true: 1) The machine can operate in one of N states in S/spl isin/{0,1,. ,N-1} where 0 is good, 1 to N-2 represent increasing levels of deterioration (i.e., the system becomes increasingly worn, but is still able to produce usable parts), and N-1 is bad (or failed). 2) Observations are related probabilistically to the state of the process. 3) The machine's state is known with certainty only immediately after a replacement. The last assumption, consistent with "silent" failures, distinguishes our results from others. We prove [using the theory & results of partially observable Markov decision processes (POMDP)] that the policy that minimizes the total expected cost of system maintenance has a "marginally monotonic" structure. The concept of "marginal monotonicity", which requires a component-wise partial ordering, and monotonicity of the expected total cost function with respect to each component of the state space, allows characterization of the policy that minimizes the total expected cost. This feature allows us to represent the optimal policy by a collection of decision rules characterized by at most N functions.
SUMO-targeted ubiquitin ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin

A new posttranslational modification is found of centromeric histone H3 variant Cse4. Cse4 is sumoylated by E3 ligases Siz1 and Siz2 and ubiquitinated by Slx5, a Sumo-targeted ubiquitin ligase. Slx5 regulates ubiquitin-mediated proteolysis of Cse4 and prevents it from being mislocalized under normal physiological conditions.
On the Comprehension of Program Comprehension

Research in program comprehension has evolved considerably over the past decades. However, only little is known about how developers practice program comprehension in their daily work. This article reports on qualitative and quantitative research to comprehend the strategies, tools, and knowledge used for program comprehension. We observed 28 professional developers, focusing on their comprehension behavior, strategies followed, and tools used. In an online survey with 1,477 respondents, we analyzed the importance of certain types of knowledge for comprehension and where developers typically access and share this knowledge. We found that developers follow pragmatic comprehension strategies depending on context. They try to avoid comprehension whenever possible and often put themselves in the role of users by inspecting graphical interfaces. Participants confirmed that standards, experience, and personal communication facilitate comprehension. The team size, its distribution, and open-source experience influence their knowledge sharing and access behavior. While face-to-face communication is preferred for accessing knowledge, knowledge is frequently shared in informal comments. Our results reveal a gap between research and practice, as we did not observe any use of comprehension tools and developers seem to be unaware of them. Overall, our findings call for reconsidering the research agendas towards context-aware tool support.
For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group. Review Hyperthermia in Cancer Treatment Hyperthermia in Combined Treatment of Cancer

Hyperthermia, the procedure of raising the temperature of tumour-loaded tissue to 40–43°C, is applied as an adjunctive therapy with various established cancer treatments such as radiotherapy and chemotherapy. The potential to control power distributions in vivo has been significantly improved lately by the development of planning systems and other modelling tools. This increased understanding has led to the design of multiantenna applicators (including their transforming networks) and implementation of systems for monitoring of E-fields (eg, electro-optical sensors) and temperature (particularly, on-line magnetic resonance tomography). Several phase III trials comparing radiotherapy alone or with hyperthermia have shown a beneficial effect of hyperthermia (with existing standard equipment) in terms of local control (eg, recurrent breast cancer and malignant melanoma) and survival (eg, head and neck lymph-node metastases, glioblastoma, cervical carcinoma). Therefore, further development of existing technology and elucidation of molecular mechanisms are justified. In recent molecular and biological investigations there have been novel applications such as gene therapy or immunotherapy (vaccination) with temperature acting as an enhancer, to trigger or to switch mechanisms on and off. However, for every particular temperature-dependent interaction exploited for clinical purposes, sophisticated control of temperature, spatially as well as temporally, in deep body regions will further improve the potential. Hyperthermia is a therapeutic procedure used to raise the temperature of a region of the body affected by cancer (figure 1). It is administered together with other cancer treatment modalities (multimodal oncological strategies). The temperature increase required can be achieved by various methods. Studies on cell cultures in vitro and on experimentally induced tumours in vivo in the early 1970s provided convincing justification for the clinical application of hyperthermia. The rationale is based on a direct cell-killing effect at temperatures above 41–42 °C. 1 However, the thermal dose–response relation varies among cell lines and depends, furthermore, on microenvironmental factors such as pH. 2 After a heat shock, all cell types show increased thermoresistance for 24–48 h (thermotolerance). The required temperatures derived from the preclinical data are not achieved under clinical conditions. Therefore, other mechanisms of heat may be relevant. A synergistic interaction between heat and radiation dose as well as various cytostatic treatments has been validated in preclinical studies. 3,4 This thermosensitisation is effective even below 41°C. Here, as found in preclinical experiments, the time between treatments and the sequence of operation are important. 5 For the combination of radiotherapy and hyperthermia, the effect is greatest for simultaneous …