Miracle-dz/UniFAR-FTUs huggingface dataset:
Body temperature and sleep at different times of day.

Six healthy male subjects were exposed to seven different bedtime conditions, one per week. Bedtimes were scheduled in 4-h intervals, resulting in times without sleep ranging from 16 h to 40 h. The influences of overt zeitgebers were minimized and the subjects were allowed to sleep until they felt they had slept enough. Rectal temperature was measured continuously and showed a circadian rhythm during both sleeping and waking. A fall in temperature immediately after sleep onset was noted at all bedtimes except at 0700 and 1900 h. In the majority of cases temperature rose toward the end of sleep, i.e., awakenings tended to occur during the rising phase of the circadian temperature rhythm. It was suggested that the phase of the body temperature rhythm is an important factor in determining sleep duration, mainly through terminating sleep during the high or rising parts of the rhythm.
Civic Disengagement in Contemporary America *

Over The Past Two Generations The United States Has Undergone a series of remarkable transformations. It has helped to defeat global communism, led a revolution in information technology that is fuelling unprecedented prosperity, invented life-saving treatments for diseases from AIDS to cancer, and made great strides in reversing discriminatory practices and promoting equal rights for all citizens. But during these same decades the United States also has undergone a less sanguine transformation: its citizens have become remarkably less civic, less politically engaged, less socially connected, less trusting, and less committed to the common good. At the dawn of the millennium Americans are fast becoming a loose aggregation of disengaged observers, rather than a community of connected participants.
Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in the Na,K-ATPase

The extent of convergent molecular evolution is largely unknown, yet is critical to understanding the genetics of adaptation. Target site insensitivity to cardenolides is a prime candidate for studying molecular convergence because herbivores in six orders of insects have specialized on these plant poisons, which gain their toxicity by blocking an essential transmembrane carrier, the sodium pump (Na,K-ATPase). We investigated gene sequences of the Na,K-ATPase α-subunit in 18 insects feeding on cardenolide-containing plants (spanning 15 genera and four orders) to screen for amino acid substitutions that might lower sensitivity to cardenolides. The replacement N122H that was previously shown to confer resistance in the monarch butterfly (Danaus plexippus) and Chrysochus leaf beetles was found in four additional species, Oncopeltus fasciatus and Lygaeus kalmii (Heteroptera, Lygaeidae), Labidomera clivicollis (Coleoptera, Chrysomelidae), and Liriomyza asclepiadis (Diptera, Agromyzidae). Thus, across 300 Myr of insect divergence, specialization on cardenolide-containing plants resulted in molecular convergence for an adaptation likely involved in coevolution. Our screen revealed a number of other substitutions connected to cardenolide binding in mammals. We confirmed that some of the particular substitutions provide resistance to cardenolides by introducing five distinct constructs of the Drosophila melanogaster gene into susceptible eucaryotic cells under an ouabain selection regime. These functional assays demonstrate that combined substitutions of Q111 and N122 are synergistic, with greater than twofold higher resistance than either substitution alone and >12-fold resistance over the wild type. Thus, even across deep phylogenetic branches, evolutionary degrees of freedom seem to be limited by physiological constraints, such that the same molecular substitutions confer adaptation.
Can surveys of women accurately track indicators of maternal and newborn care? A validity and reliability study in Kenya

Background Tracking progress on maternal and newborn survival requires accurate information on the coverage of essential interventions. Despite widespread use, most indicators measuring maternal and newborn intervention coverage have not been validated. This study assessed the ability of women delivering in two Kenyan hospitals to recall critical elements of care received during the intrapartum and immediate postnatal period at two time points: hospital discharge and 13–15 months following delivery. Methods Women’s reports of received care were compared against observations by trained third party observers. Indicators selected for validation were either currently in use or have the potential to be included in population–based surveys. We used a mixed–methods approach to validate women’s reporting ability. We calculated individual–reporting accuracy using the area under the receiver operating curve (AUC), population–level accuracy using the inflation factor (IF), and compared the accuracy of women’s reporting at baseline and follow–up. We also assessed the consistency of women’s reporting over time. We used in–depth interviews with a sub–set of women (n = 20) to assess their understanding of key survey terms. Results Of 606 women who participated at baseline and agreed to follow–up, 515 were re–interviewed. Thirty–eight indicators had sufficient sample size for validation analysis; ten met criteria for high or moderate reporting accuracy (0.60<AUC) alone and ten met criteria for low population–level bias alone (0.75<IF<1.25). There was a significant decline in the individual level reporting accuracy between baseline and follow–up for ten indicators. Seven indicators had moderate or higher (0.4≤rphi) consistency between self–reports at baseline and follow–up. Four indicators met all criteria at follow–up: support person was present during the birth, episiotomy, caesarean section, and low birthweight infant (<2500 g). Conclusion The few indicators that women reported accurately at baseline were consistently recalled with accuracy at 13–15 months follow–up. Although there is deterioration in women’s recall in some indicators over time, the extent of deterioration does not appreciably compromise reporting accuracy for indicators with high baseline validity. Indicators related to initial client assessment and the immediate postnatal period have generally low accuracy and poor reporting consistency over time.
The Persistence of Materialist and Post-Materialist Value Orientations

The theory of the Silent Revolution relates value change to the process of population replacement. Materialist and post-materialist values are seen as reflections of the conditions that prevailed during one's pre-adult years. This assumption is tested here by analysing a Dutch panel, questioned in 1974 and in 1970. The change actually found at the individual level is not in line with the predictions of the theory and leads to a dilemma. The first option implies a rejection of the socialization hypothesis - one of the cornerstones of the theory. The second option places considerable doubts on the reliability of the instrument. Moreover, the validity of the instrument seems to be questionable too. The remarkably similar marginal distribution of the materialist and post-materialist value types in both years, accompanied by massive shifts between the types, points into the direction of political attitudes and non-attitudes instead of basic orientations or basic outlooks.
Axonal transport of neural membrane protein 35 mRNA increases axon growth

Summary Many neuronal mRNAs are transported from cell bodies into axons and dendrites. Localized translation of the mRNAs brings autonomy to these processes that can be vast distances from the cell body. For axons, these translational responses have been linked to growth and injury signaling, but there has been little information about local function of individual axonally synthesized proteins. In the present study, we show that axonal injury increases levels of the mRNA encoding neural membrane protein 35 (NMP35) in axons, with a commensurate decrease in the cell body levels of NMP35 mRNA. The 3′ untranslated region (3′UTR) of NMP35 is responsible for this localization into axons. Previous studies have shown that NMP35 protein supports cell survival by inhibiting Fas-ligand-mediated apoptosis; however, these investigations did not distinguish functions of the locally generated NMP35 protein. Using axonally targeted versus cell-body-restricted NMP35 constructs, we show that NMP35 supports axonal growth, and overexpression of an axonally targeted NMP35 mRNA is sufficient to increase axonal outgrowth.
Children with medical complexity: a scoping review of interventions to support caregiver stress

BACKGROUND Caring for children with chronic and complex medical needs places extraordinary stress on parents and other family members. A scoping review was undertaken to identify and describe the full range of current interventions for reducing caregiver stress. METHODS Applying a broad definition of caregiver stress, a systematic search of three scientific databases (CINAHL, Embase and Ovid Medline), a general internet search and hand searching of key peer-reviewed articles were conducted. Inclusion criteria were as follows: (i) published in English between 2004-2016; (ii) focused on familial caregivers, defined as parents, siblings or extended family; (iii) targeted children/youth with medical complexity between the ages of 1-24 years; and (iv) described an intervention and impact on caregiver stress. Data on type of intervention, study design and methods, measures and overall findings were extracted. RESULTS Forty-nine studies were included from a list of 22 339 unique titles. Six domains of interventions were found: care coordination models (n = 23); respite care (n = 8); telemedicine (n = 5); peer and emotional support (n = 6); insurance and employment benefits (n = 4); and health and related supports (n = 3). Across studies, there was a wide variety of designs, outcomes and measures used. CONCLUSIONS Positive findings of reductions in caregiver stress were noted within an emerging body of evidence on effective interventions for families of children with medical complexity. A commonality across domains was a significant focus on streamlining services and reducing the burden of care related to varied pressures experienced, including time, finances, care needs and service access, among others. There was non-conclusive evidence however around which of the six identified intervention domains or combination thereof are most effective for reducing stress. These promising findings demonstrate that stress reduction is possible with the right support and that multiple interventions may be effective in reducing burdens of care experienced by families of children with medical complexity.
Learning Image Classification and Retrieval Models. (Apprentissage de Modèles pour la Classification et la Recherche d'Images)

We are currently experiencing an exceptional growth of visual data, for example, millions of photos are shared daily on social-networks. Image understanding methods aim to facilitate access to this visual data in a semantically meaningful manner. In this dissertation, we define several detailed goals which are of interest for the image understanding tasks of image classification and retrieval, which we address in three main chapters. First, we aim to exploit the multi-modal nature of many databases, wherein documents consists of images with a form of textual description. In order to do so we define similarities between the visual content of one document and the textual description of another document. These similarities are computed in two steps, first we find the visually similar neighbors in the multi-modal database, and then use the textual descriptions of these neighbors to define a similarity to the textual description of any document. Second, we introduce a series of structured image classification models, which explicitly encode pairwise label interactions. These models are more expressive than independent label predictors, and lead to more accurate predictions. Especially in an interactive prediction scenario where a user provides the value of some of the image labels. Such an interactive scenario offers an interesting trade-off between accuracy and manual labeling effort. We explore structured models for multi-label image classification, for attribute-based image classification, and for optimizing for specific ranking measures. Finally, we explore k-nearest neighbors and nearest-class mean classifiers for large-scale image classification. We propose efficient metric learning methods to improve classification performance, and use these methods to learn on a data set of more than one million training images from one thousand classes. Since both classification methods allow for the incorporation of classes not seen during training at near-zero cost, we study their generalization performances. We show that the nearest-class mean classification method can generalize from one thousand to ten thousand classes at negligible cost, and still perform competitively with the state-of-the-art.
The semiclassical limit of loop quantum cosmology

The continuum and semiclassical limits of isotropic, spatially flat loop quantum cosmology are discussed, with an emphasis on the role played by the Barbero-Immirzi γ parameter in controlling spacetime discreteness. In this way, standard quantum cosmology is shown to be the simultaneous limit γ→0, j→∞ of loop quantum cosmology. Here, j is a label of the volume eigenvalues, and the simultaneous limit is technically the same as the classical limit →0, l→∞ of angular momentum in quantum mechanics. Possible lessons for semiclassical states at the dynamical level in the full theory of quantum geometry are mentioned.
Subcomponent Vaccine Based on CTA1-DD Adjuvant with Incorporated UreB Class II Peptides Stimulates Protective Helicobacter pylori Immunity

A mucosal vaccine against Helicobacter pylori infection could help prevent gastric cancers and peptic ulcers. While previous attempts to develop such a vaccine have largely failed because of the requirement for safe and effective adjuvants or large amounts of well defined antigens, we have taken a unique approach to combining our strong mucosal CTA1-DD adjuvant with selected peptides from urease B (UreB). The protective efficacy of the selected peptides together with cholera toxin (CT) was first confirmed. However, CT is a strong adjuvant that unfortunately is precluded from clinical use because of its toxicity. To circumvent this problem we have developed a derivative of CT, the CTA1-DD adjuvant, that has been found safe in non-human primates and equally effective compared to CT when used intranasally. We genetically fused the selected peptides into the CTA1-DD plasmid and found after intranasal immunizations of Balb/c mice using purified CTA1-DD with 3 copies of an H. pylori urease T cell epitope (CTA1-UreB3T-DD) that significant protection was stimulated against a live challenge infection. Protection was, however, weaker than with the gold standard, bacterial lysate+CT, but considering that we only used a single epitope in nanomolar amounts the results convey optimism. Protection was associated with enhanced Th1 and Th17 immunity, but immunizations in IL-17A-deficient mice revealed that IL-17 may not be essential for protection. Taken together, we have provided evidence for the rational design of an effective mucosal subcomponent vaccine against H. pylori infection based on well selected protective epitopes from relevant antigens incorporated into the CTA1-DD adjuvant platform.
The student learning process: Learning styles or learning approaches?

The Learning Styles school and the Approaches to Learning school represent two rather different perspectives on the interaction of students with a learning situation. This paper outlines the basic positions of the two schools, and then considers the extent to which it is possible to reconcile them. A possible framework for such a task by Riding (1997) is discussed and areas of commonality are highlighted. Neither school is free from criticism, and a summary of the criticisms of the constructs and the data collection instruments is provided in each case. Finally, research into the impact of the two schools on student learning is considered. Overall it is concluded that investigation of students’ Learning Styles or Approaches to Learning are probably of more benefit to the teacher than to the individual student.
Whose brain is initial-like?

We review the evidence for the concept of the "initial" or prototype brain. We outline four possible modes of brain evolution suggested by our new findings on the evolutionary status of the dolphin brain. The four modes involve various forms of deviation from and conformity to the hypothesized initial brain type. These include examples of conservative evolution, progressive evolution, and combinations of the two in which features of one or the other become dominant. The four types of neocortical organization in extant mammals may be the result of selective pressures on sensory/motor systems resulting in divergent patterns of brain phylogenesis. A modular "modification/multiplication" hypothesis is proposed as a mechanism of neocortical evolution in eutherians. Representative models of the initial ancestral group of mammals include not only extant basal Insectivora but also Chiroptera; we have found that dolphins and large whales have also retained many features of the archetypal or initial brain. This group evolved from the initial mammalian stock and returned to the aquatic environment some 50 million years ago. This unique experiment of nature shows the effects of radical changes in environment on brain-body adaptations and specializations. Although the dolphin brain has certain quantitative characteristics of the evolutionary changes seen in the higher terrestrial mammals, it has also retained many of the conservative structural features of the initial brain. Its neocortical organization is accordingly different, largely in a quantitative sense, from that of terrestrial models of the initial brain such as the hedgehog.
Maximizing spatial congruence of observed and DEM-delineated overland flow networks

Model simulated overland flow is traditionally routed by the terrain-based algorithms that read 90 to 10-m pixel data, yet observed flow is often influenced by sub-meter micro-terrain features. While sub-meter terrain maps are not available for most watersheds, routing algorithms that bifurcate flow through multiple pixel boundaries may function to match observed runoff patterns. This paper assesses the spatial congruence between observed overland flow from two agricultural hillslopes in New Jersey with 30-m pixel flowpaths predicted by five common routing algorithms known as D8, Multiple Flow, 2D-Lea, (a building block in DEMON), 2D-Jensen, and D-Infinity. The lowest congruence ratings were assigned to D8, which constrained flow to a single neighbour, and MF, which bifurcated flow into all neighbours lower in elevation. 2D-Lea and D-Infinity, algorithms that bifurcated flow to a maximum of two neighbours, achieved the highest accuracy rankings. Simple algorithm modifications that increased D8 bifurcation, and constrained MF bifurcation, resulted in congruence rankings that rivaled the more sophisticated 2D-Lea, 2D-Jensen, and D-Infinity results. These experiments support the use of flow bifurcation schemes that pass flow into a maximum of between two and three pixels when routing polluted runoff.
Implicit stereotype content: Mixed stereotypes can be measured with the Implicit Association Test

The stereotype content model (SCM) postulates that stereotype content can be mixed in terms of diverging evaluations on the warmth and competence dimensions. The present study is the first to demonstrate this with implicit measures. Two Implicit Associations Tests (IATs) were developed, one capturing the warmth dimension and the other the competence dimension. Both IATs compared preschool teachers (stereotypically warm and incompetent) with lawyers (stereotypically cold and competent). As predicted, two samples of students from various areas of study showed the mixed implicit stereotypes, while a group of preschool-teacher students showed a univalent positive implicit stereotype of their own group, suggesting in-group favoritism. The results support the SCM.
Variation in Australian English. The Sociolects of Sydney

Barbara Horvath's study of the English spoken in Sydney is an important and timely contribution to our knowledge about varieties of English in the world and about variation in urban dialects in particular. It is the first large-scale work to apply recent advances in sociolinguistic theory and methodology to Australian English, and to take account of the complex social changes resulting from immigration that are taking place in Australia's urban population. The study is based on a survey of Sydneysiders of Anglo-Celtic, Greek and Italian background, and is significant not only for the variety of techniques employed in the sociolinguistic analysis, but also for the linguistic variables considered. Dr Horvath's quantitative analysis of intonation and text is a particularly welcome innovation. The volume concludes with an attempt to return to an integrated view of dialect based on co-occuring linguistic features.
The Role of Identification in Giving Sense to Unethical Organizational Behavior

This language production experiment investigates communication’s role in defending, and therefore giving sense to, organizational wrongdoing. The study suggests identification may possibly reduce organizations’ moral learning capacity by encouraging highly identified members to engage in ethical sensegiving of their organizations’ wrongdoing in defensive ways. Working adults (N = 318) responded to an organizational outsider regarding a gender discrimination lawsuit filed against their organization in one of two scenarios, which presented the organization’s guilt as either ambiguous or certain. Highly identified members used more linguistic defense mechanisms and reported more intense feelings. Additionally, participants in the ambiguous condition used more linguistic defense mechanisms than those in the certain condition. Veteran members reported higher levels of organizational identification and used more linguistic defense mechanisms than newcomers.
Are School Factors Important for Measuring Teacher Effectiveness? A Multilevel Technique to Predict Student Gains through a Value-Added Approach

This paper investigated the effect of teacher quality, represented by teacher level characteristics, on mathematics gain scores employing a three-level hierarchical linear model (HLM) through value-added model (VAM) approach. The analysis investigated significant predictors at student, teacher, and school levels for predicting students' gain scores and also estimated d-type effect sizes at teacher and school levels. We found the significant effects of teacher's mathematics content certification, teacher experience, and the interaction effects of mathematics content certification with student level predictors. Although school poverty significantly predicted students' gain scores, the school level effect was relatively small.