Miracle-dz/UniFAR-FTUs huggingface dataset:
Extratropical Transition of Southwest Pacific Tropical Cyclones. Part II: Midlatitude Circulation Characteristics

Abstract This second of two papers on extratropical transition (ET) over the southwest Pacific Ocean focuses on the variability of ET. A climatology of ET onset based on a previously described objective technique shows that ET commences 15° of latitude nearer the equator on average than similar cases from the Northern Hemisphere. Characteristic midlatitude circulation patterns accompanying ET near 30°S are identified by means of empirical orthogonal function (EOF) analysis of 50 storms. The first eigenvector pattern, explaining nearly half the circulation variability, expresses relaxed and enhanced pressure gradients south of the storm that define composites similar to “cradled” and “captured” classifications previously described for the southeast Indian Ocean. The second EOF distinguishes redeveloping from weakening storms. Reintensifying storms were located beneath strong cyclonic vorticity advection (CVA) near the equatorward entrance region of an upper jet whereas the upper jet was well to the west of.
A Mutation in LTBP2 Causes Congenital Glaucoma in Domestic Cats (Felis catus)

The glaucomas are a group of diseases characterized by optic nerve damage that together represent a leading cause of blindness in the human population and in domestic animals. Here we report a mutation in LTBP2 that causes primary congenital glaucoma (PCG) in domestic cats. We identified a spontaneous form of PCG in cats and established a breeding colony segregating for PCG consistent with fully penetrant, autosomal recessive inheritance of the trait. Elevated intraocular pressure, globe enlargement and elongated ciliary processes were consistently observed in all affected cats by 8 weeks of age. Varying degrees of optic nerve damage resulted by 6 months of age. Although subtle lens zonular instability was a common feature in this cohort, pronounced ectopia lentis was identified in less than 10% of cats examined. Thus, glaucoma in this pedigree is attributed to histologically confirmed arrest in the early post-natal development of the aqueous humor outflow pathways in the anterior segment of the eyes of affected animals. Using a candidate gene approach, significant linkage was established on cat chromosome B3 (LOD 18.38, θ = 0.00) using tightly linked short tandem repeat (STR) loci to the candidate gene, LTBP2. A 4 base-pair insertion was identified in exon 8 of LTBP2 in affected individuals that generates a frame shift that completely alters the downstream open reading frame and eliminates functional domains. Thus, we describe the first spontaneous and highly penetrant non-rodent model of PCG identifying a valuable animal model for primary glaucoma that closely resembles the human disease, providing valuable insights into mechanisms underlying the disease and a valuable animal model for testing therapies.
Phylogenetic relationships in the Niviventer-Chiromyscus complex (Rodentia, Muridae) inferred from molecular data, with description of a new species

Abstract Based on molecular data for mitochondrial (Cyt b, COI) and nuclear (IRBP, GHR) genes, and morphological examinations of museum specimens, we examined diversity, species boundaries, and relationships within and between the murine genera Chiromyscus and Niviventer. Phylogenetic patterns recovered demonstrate that Niviventer sensu lato is not monophyletic but instead includes Chiromyscus chiropus, the only previously recognized species of Chiropus. To maintain the genera Niviventer and Chiropus as monophyletic lineages, the scope and definition of the genus Chiromyscus is revised to include at least three distinct species: Chiromyscus chiropus (the type species of Chiromyscus), Chiromyscus langbianis (previously regarded as a species of Niviventer), and a new species, described in this paper under the name Chiromyscus thomasi sp. n.
Superinfection Exclusion between Two High-Risk Human Papillomavirus Types during a Coinfection

ABSTRACT Superinfection exclusion is a common phenomenon whereby a single cell is unable to be infected by two types of the same pathogen. Superinfection exclusion has been described for various viruses, including vaccinia virus, measles virus, hepatitis C virus, influenza A virus, and human immunodeficiency virus. Additionally, the mechanism of exclusion has been observed at various steps of the viral life cycle, including attachment, entry, viral genomic replication, transcription, and exocytosis. Human papillomavirus (HPV) is the causative agent of cervical cancer. Recent epidemiological studies indicate that up to 50% women who are HPV positive (HPV+) are infected with more than one HPV type. However, no mechanism of superinfection exclusion has ever been identified for HPV. Here, we show that superinfection exclusion exists during a HPV coinfection and that it occurs on the cell surface during the attachment/entry phase of the viral life cycle. Additionally, we are able to show that the minor capsid protein L2 plays a role in this exclusion. This study shows, for the first time, that superinfection exclusion occurs during HPV coinfections and describes a potential molecular mechanism through which it occurs. IMPORTANCE Superinfection exclusion is a phenomenon whereby one cell is unable to be infected by multiple related pathogens. This phenomenon has been described for many viruses and has been shown to occur at various points in the viral life cycle. HPV is the causative agent of cervical cancer and is involved in other anogenital and oropharyngeal cancers. Recent epidemiological research has shown that up to 50% of HPV-positive individuals harbor more than one type of HPV. We investigated the interaction between two high-risk HPV types, HPV16 and HPV18, during a coinfection. We present data showing that HPV16 is able to block or exclude HPV18 on the cell surface during a coinfection. This exclusion is due in part to differences in the HPV minor capsid protein L2. This report provides, for the first time, evidence of superinfection exclusion for HPV and leads to a better understanding of the complex interactions between multiple HPV types during coinfections.
How do children construct the color lexicon? : Restructuring the domain as a connected system

The present study investigated how children learn the meanings of basic color words and are immersed into the language-specific system of the color lexicon. The study examined how children discover the boundaries of color names by having 3-, 4-, and 5year-old children produce names for 93 color patches. We found that even 3-year-olds children can map color words to its typical referents. At the same time, they struggle to delineate the boundaries between neighboring color words. The results indicated that, in learning color words, children continuously restructure the entire semantic domain by discovering and adjusting the linguistic boundaries between the neighboring words.
Hot ductility behaviour of high manganese steels with varying aluminium contents

The influence of aluminium on the hot ductility of high manganese steels between 700°C and Tliq has been examined, using the hot tensile test machine. Five materials with 17 wt-% [Mn], 0.3 wt-% [C] and 0–8 wt-% [Al] were cast. To detect the cause of cracking, optical microscopy and scanning electron microscopy analysis of the fracture surfaces have been conducted and compared to thermodynamic modelling. By adding more than 3 wt-% [Al] the fully austenitic structure changed to a two-phase structure (δ-Fe, γ-Fe). In case of the one- and also two-phase structured materials two regions of lower ductility (<30% RA) are present. Complex (AlN) and Mn(S,Se) precipitates were formed with different cores in dependence of the [Al] content.
Preferences for and evaluation of self‐relevant information depending on the elaboration of the self‐schemata involved

Previous findings have shown that some reactions (e.g. satisfaction with feedback) are guided by self-enhancement theory, whereas other reactions (e.g. perceived feedback accuracy) have been shown to follow predictions of self-consistency theory. The Integrative Self-Schema Model (ISSM) assumes that these effects should be moderated by the elaboration of the self-schema involved: This assumption was tested in an experimental study: 72 participants received fictitious feedback on different personality dimensions allegedly based on an adjective checklist. This feedback was either consistent with self-perceptions, more positive than expected, or more negative than expected, and addressed highly elaborated (schematic) or less elaborated (aschematic) personality dimensions. Satisfaction, feedback accuracy and interest in further information were analysed as dependent variables. The experimental results clearly confirmed the hypotheses derived from the ISSM for satisfaction and perceived feedback accuracy. A self-consistency effect regarding perceived feedback accuracy was found only for feedback on schematic dimensions but was attenuated on aschematic dimensions. A self-enhancement effect regarding satisfaction was found only on aschematic dimensions. This finding was reversed on schematic dimensions. Finally, interest in further information did not follow the predictions made by the ISSM.
Progressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia.

CONTEXT Progressive brain abnormalities in schizophrenia remain controversial. Evidence of interrelated progressive functional impairment would buttress the case for structural progression. Mismatch negativity (MMN) is reduced in chronic but not first-hospitalized schizophrenia and may index progressive structural changes. OBJECTIVE To determine whether MMN shows associations with underlying auditory cortex gray matter at first hospitalization and progressive reduction longitudinally. DESIGN Cross-sectional (first hospitalization) and longitudinal (1.5-year follow-up). SETTING A private psychiatric hospital. PARTICIPANTS Protocol entrance: MMN and magnetic resonance imaging at first hospitalization in 20 subjects with schizophrenia, 21 subjects with bipolar disorder with psychosis, and 32 control subjects. Longitudinal electrophysiologic testing: MMN in 16 subjects with schizophrenia, 17 subjects with bipolar disorder, and 20 control subjects. Longitudinal electrophysiologic testing and magnetic resonance imaging: MMN and magnetic resonance imaging in 11 subjects with schizophrenia, 13 subjects with bipolar disorder, and 13 control subjects. At each time point, reported samples were group matched for age, handedness, and parental socioeconomic status. INTERVENTIONS Electrophysiologic testing and high-resolution structural magnetic resonance imaging. MAIN OUTCOME MEASURES Mismatch negativity amplitude and Heschl gyrus and planum temporale gray matter volumes. RESULTS Initially, groups did not differ in MMN amplitude. Subjects with schizophrenia showed associations between MMN and Heschl gyrus (r=-0.52; P=.02) not present in the other groups. At longitudinal MMN testing, schizophrenia showed MMN reduction (P=.004). Only schizophrenia evinced longitudinal left hemisphere Heschl gyrus reduction (P=.003), highly correlated with MMN reduction (r=0.6; P=.04). CONCLUSIONS At first hospitalization for schizophrenia, MMN indexed left hemisphere Heschl gyrus gray matter volume, consistent with variable progression of pre-hospitalization cortical reduction. Longitudinally, the interrelated progressive reduction of functional and structural measures suggests progressive pathologic processes early in schizophrenia. An active process of progressive cortical reduction presents a potential therapeutic target. Mismatch negativity may be a simple, sensitive, and inexpensive index not only of this progressive pathologic process but also of successful intervention.
induction of PD-l 1 expression by epidermal growth factor receptor – mediated signaling in esophageal squamous cell carcinoma

and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). OncoTargets and Therapy 2017:10 763–771 OncoTargets and Therapy Dovepress
Effect of replacing a commercial pelleted calf meal with lucerne leaf-meal on performance of neonatal and transitional Holstein heifer calves

A study was conducted to (i) determine in vitro ruminal dry matter (DM) fermentation kinetics, effective rumen degradation of DM (EDDM), (ii) estimate energy fractions supply of lucerne leaf-meal (LLM) and composite diets of LLM with commercial pelleted calf meal and also (iii) determine the effects of substituting commercial pelleted calf meal with LLM on the intake, % ruminal nitrogen balance (RNB) and growth of the neonates (21–42 days old) and transition (43–56 days old) Holstein heifer calves. Forty-eight Holstein heifer calves were randomly assigned to three different dietary treatments in a complete randomised design of: (a) pelleted concentrate (PEL), (b) 65% pelleted concentrate: 35% LLM (P65 L35); (c) and 50% pelleted concentrate: 50% LLM (P50 L50). The study comprised of two experiments: neonatal (Experiment 1) and transition (Experiment 2) phases. Lucerne leaf-meal had gross energy of 16.2 MJ/kg and 25% crude protein DM. PEL diet was high in starch and bound protein compared with other diets. Inclusion of LLM in diets increased calcium levels but tended to decrease phosphorus levels. Calves were weaned at the age of 56 days. The feeds were incubated for 0, 4, 10, 18, 24 and 48 h using a DaisyII incubator. Rumen fluid was obtained from calves <50 days old. Large Ruminant Nutrition System was used to predict %RNB and energy density of the diets during neonatal and transition phases. Higher mean EDDM levels were found with LLM inclusions whereas fractions a, a + b and c did not vary. Neonates on diet C had higher (P < 0.05) daily DM and crude protein intakes, %RNB, total digestible nutrients, net energy at maintenance and net energy at gain during neonatal phase. Performance of calves was similar during the transition phase. LLM should be considered as a concentrate replacement in diets of neonates and calves.
Recycling of carbon fiber-reinforced thermoplastic composite wastes from the aerospace industry

Post-industrial trimmings and off-cuts of carbon fiber/polyether ether ketone composite were successfully recycled into new composite products. The original composites were thermally characterized by dynamic thermomechanical analysis, differential scanning calorimetry, and thermogravimetric analysis. Melt-bonding and thermoset adhesives were used to bond the carbon fiber/polyether ether ketone. Performance of the bond was evaluated through double lap-shear tests. The carbon fiber/polyether ether ketone scraps were mechanically refined to a variety of elemental sizes, subsequently subjected to high-temperature hot pressing to form panel composites. The influences of element size and processing temperature were evaluated through mechanical testing.
Krüppel-like Factor 4 Regulates Intestinal Epithelial Cell Morphology and Polarity

Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine. In normal intestine, KLF4 is predominantly expressed in the differentiated epithelial cells. It has been identified as a tumor suppressor in colorectal cancer. KLF4 knockout mice demonstrated a decrease in number of goblet cells in the colon, and conditional ablation of KLF4 from the intestinal epithelium led to altered epithelial homeostasis. However, the role of KLF4 in differentiated intestinal cells and colon cancer cells, as well as the mechanism by which it regulates homeostasis and represses tumorigenesis in the intestine is not well understood. In our study, KLF4 was partially depleted in the differentiated intestinal epithelial cells by a tamoxifen-inducible Cre recombinase. We found a significant increase in the number of goblet cells in the KLF4-deleted small intestine, suggesting that KLF4 is not only required for goblet cell differentiation, but also required for maintaining goblet cell numbers through its function in inhibiting cell proliferation. The number and position of Paneth cells also changed. This is consistent with the KLF4 knockout study using villin-Cre [1]. Through immunohistochemistry (IHC) staining and statistical analysis, we found that a stem cell and/or tuft cell marker, DCAMKL1, and a proliferation marker, Ki67, are affected by KLF4 depletion, while an enteroendocrine cell marker, neurotensin (NT), was not affected. In addition, we found KLF4 depletion altered the morphology and polarity of the intestinal epithelial cells. Using a three-dimensional (3D) intestinal epithelial cyst formation assay, we found that KLF4 is essential for cell polarity and crypt-cyst formation in human colon cancer cells. These findings suggest that, as a tumor suppressor in colorectal cancer, KLF4 affects intestinal epithelial cell morphology by regulating proliferation, differentiation and polarity of the cells.
Failed internal fixation of femoral neck fractures.

BACKGROUND There are two types of surgical treatment for fractures of the femoral neck; internal fixation and arthroplasty. Internal fixation is associated with a higher risk of complications such as secondary displacement, non-union and avascular necrosis. To improve treatment results of internal fixation, we have tried to identify procedure related risk-factors associated with fixation failure. MATERIAL AND METHOD A retrospective study was conducted based on the medical records and X-ray images of 337 patients sustaining intracapsular fractures of the hip during the period 1999-2000. The patients were treated with closed reduction and internal fixation at Oslo University Hospital, Aker. The reduction of the fracture and the placement of the fixation implants were evaluated and scored (six points representing best achievable result). RESULTS Fixation failed in 23 (18,3 %) out of 126 patients with displaced fractures awarded six points for the reduction. In contrast, fixation failed in five (50 %) out of ten patients given a score of three points or less (p = 0.017). The risk of non-union increased when patients were treated more than 48 hours after the initial injury. In this group, 5 (25 %) out of 20 patients developed non-union compared to 16 (8 %) out of 200 patients treated within 48 hours (p = 0.014). INTERPRETATION Our findings emphasize the importance of achieving anatomical reduction of displaced femoral neck fractures, and to perform surgery within 48 hours unless an acute medical condition needs to be stabilized.
Hierarchical Attention and Context Modeling for Group Activity Recognition

Group activity recognition in videos is a challenging task, with two major issues, i.e. attending to those persons and their body parts that contribute significantly to the activity, and modeling contextual person structures in the group. Most previous approaches fail to provide a practical solution to jointly address both issues, however. In this paper, we propose to simultaneously deal with both issues via a hierarchical attention and context modeling framework based on Long Short-Term Memory (LSTM) networks. For the former, we propose ‘Hierarchical Attention Networks' applied at the part/person level, capable of attending distinctively to different persons and their body parts. For the latter, we build ‘Hierarchical Context Networks' that take the attentively pooled person-level features as input and recurrently model intra/inter-group contextual structures. The attentive and contextual representations are concatenated and fed into another LSTM to generate high-level discriminative temporal representations for group activity recognition. Extensive experiments on two widely-used group activity datasets demonstrate the effectiveness and superiority of the proposed framework.
Natural Products for the Treatment of Type 2 Diabetes Mellitus

Abstract Type 2 diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. High blood sugar can produce long-term complications such as cardiovascular and renal disorders, retinopathy, and poor blood flow. Its development can be prevented or delayed in people with impaired glucose tolerance by implementing lifestyle changes or the use of therapeutic agents. Some of these drugs have been obtained from plants or have a microbial origin, such as galegine isolated from Galega officinalis, which has a great similarity to the antidiabetic drug metformin. Picnogenol, acarbose, miglitol, and voglibose are other antidiabetic products of natural origin. This review compiles the principal articles on medicinal plants used for treating diabetes and its comorbidities, as well as mechanisms of natural products as antidiabetic agents. Inhibition of α-glucosidase and α-amylase, effects on glucose uptake and glucose transporters, modification of mechanisms mediated by the peroxisome proliferator-activated receptor, inhibition of protein tyrosine phosphatase 1B activity, modification of gene expression, and activities of hormones involved in glucose homeostasis such as adiponectin, resistin, and incretin, and reduction of oxidative stress are some of the mechanisms in which natural products are involved. We also review the most relevant clinical trials performed with medicinal plants and natural products such as aloe, banaba, bitter melon, caper, cinnamon, cocoa, coffee, fenugreek, garlic, guava, gymnema, nettle, sage, soybean, green and black tea, turmeric, walnut, and yerba mate. Compounds of high interest as potential antidiabetics are: fukugetin, palmatine, berberine, honokiol, amorfrutins, trigonelline, gymnemic acids, gurmarin, and phlorizin.
Deep Globally Constrained MRFs for Human Pose Estimation

This work introduces a novel Convolutional Network architecture (ConvNet) for the task of human pose estimation, that is the localization of body joints in a single static image. We propose a coarse to fine architecture that addresses shortcomings of the baseline architecture in [26] that stem from the fact that large inaccuracies of its coarse ConvNet cannot be corrected by the refinement ConvNet that refines the estimation within small windows of the coarse prediction. We overcome this by introducing a Markov Random Field (MRF)-based spatial model network between the coarse and the refinement model that introduces geometric constraints on the relative locations of the body joints. We propose an architecture in which a) the filters that implement the message passing in the MRF inference are factored in a way that constrains them by a low dimensional pose manifold the projection to which is estimated by a separate branch of the proposed ConvNet and b) the strengths of the pairwise joint constraints are modeled by weights that are jointly estimated by the other parameters of the network. The proposed network is trained in an end-to-end fashion. Experimental results show that the proposed method improves the baseline model and provides state of the art results on very challenging benchmarks.