Miracle-dz/UniFAR-FTUs huggingface dataset:
Contact urticaria with anaphylactic reactions caused by occupational exposure to iridium salt

This paper presents the case of a non‐smoking and non‐atopic male, exposed to indium chloride at work, who developed respiratory tract symptoms and contact urticaria. Application of indium salt to normal skin caused contact urticaria. An iridium chloride prick test showed a positive reaction and a scratch test produced anaphylactoid reactions. Platinum salt allergy was excluded through prick testing with hexachloroplatinate solution. There is no previous report describing a case where an individual has a positive prick test reaction to iridium salts and simultaneously a negative one to platinum salts. The results are interpreted as immediate‐type hypersensitivity (Type I allergy? ) to iridium salt. The route of sensitization was probably through the airways. Further testing showed that iridium salt allergy could persist for at least 18 months after exposure ceases. 14 employees at the same factory were prick tested with iridium and platinum salts with negative results. Prick testing is recommended as a method of first choice when investigating a person with suspected indium salt allergy.
Acupuncture for the Trauma Spectrum Response: Scientific Foundations, Challenges to Implementation

Abstract The long wars in Iraq and Afghanistan have produced extensive and often repeated trauma to United States service members and their families. These injuries occur to the mind, the brain, the body and the soul. The current approach to management of these injuries follows the standard medical model that attempts to isolate the pathophysiological locations and processes affected by the injury and provide specialized care for that part of the person—psychological treatment for mind injuries, neurological treatment for brain injuries, and surgical and rehabilitation approaches for body injuries. This model is overwhelmingly dominated by the use of drugs for symptom management. Yet, research has shown that, no matter where an injury is located, its impact and the healing responses to it cut across these boundaries resulting in a common symptomatic and functional spectrum. The authors of this article have called this the war-related trauma spectrum response (wrTSR) and propose a better approach to this s.
A phase II study of dose‐dense and dose‐intense ABVD (ABVDDD‐DI) without consolidation radiotherapy in patients with advanced Hodgkin lymphoma

We explored activity and safety of a dose‐dense/dose‐intense adriamycin, bleomycin, vinblastine and dacarbazine regimen (ABVDDD‐DI) in 82 patients with advanced Hodgkin Lymphoma. Patients entered a two‐stage Bryant‐Day Phase II study to receive six cycles of ABVDDD‐DI without consolidation radiotherapy. Cycles were supported with granulocyte colony‐stimulating factor and delivered every 21 d; drugs were administered on days 1 and 11 at the same doses of standard ABVD except for doxorubicin (35 mg/m2; first four cycles only). Co‐primary endpoints were complete response (CR) rate and severe acute cardiopulmonary toxicity; secondary endpoints were event‐free (EFS) and disease‐free survival (DFS). All patients received the four doxorubicin‐intensified courses and 96% concluded all six cycles (82·3% within the intended 18 weeks). This translated into a 66·9% increase of received dose‐intensity for doxorubicin and 31·8% for the other agents over standard ABVD. The CR rate was 95·1% (78/82) and 87·8% (72/82) achieved a metabolic CR after two cycles. Cardiopulmonary toxicity never exceeded grade 2 and affected 14·6% of patients. Most frequent toxicities were grade 4 neutropenia (10%) and anaemia (9%), grade 3 infection (17%) and grade 2 mucocutaneous changes (30%). Five‐year EFS and DFS was 88·3% and 93·7%, respectively. ABVDDD‐DI regimen was well‐tolerated and ensured substantial CR and EFS rates without radiotherapy.
Identification of a Broadly Active Phage Lytic Enzyme with Lethal Activity against Antibiotic-Resistant Enterococcus faecalis and Enterococcus faecium

ABSTRACT Enterococcus faecalis and Enterococcus faecium infections are increasingly difficult to treat due to high levels of resistance to antibiotics. PlyV12, a bacteriophage lytic enzyme, was isolated and shown to effectively kill both E. faecalis and E. faecium (including vancomycin-resistant strains), as well as other human pathogens. We propose its development and use as an alternative therapeutic tool.
On the out-of-equilibrium order parameter in long-range spin-glasses

We show that the dynamical order parameters can be re-expressed in terms of the distribution of the staggered auto-correlation and response functions. We calculate these distributions for the out of equilibrium dynamics of the Sherrington-Kirkpatrick model at long times. The results suggest that the landscape this model visits at different long times in an out-of-equilibrium relaxation process is, in a sense, self-similar. Furthermore, there is a similarity between the landscape seen out of equilibrium at long times and the equilibrium landscape. The calculation is greatly simplified by making use of the superspace notation in the dynamical approach. This notation also highlights the rather mysterious formal connection between the dynamical and replica approaches. We also perform numerical simulations which show good agreement with the analytical results for the out of equilibrium dynamics.
"Girls are better at language learning than boys": Do stereotypic beliefs about language learning contribute to girls' higher motivation to learn English in primary school?

Dieser Artikel untersucht die Sprachlernmotivation von Primarschulkindern bezuglich Englisch, mit besonderem Augenmerk auf Geschlechterunterschiede und deren moglichen Ursachen. Wahrenddem bisherige Untersuchungen in der Schweiz darauf hinweisen, dass Englisch, im Gegensatz zu Franzosisch, welches von den Madchen bevorzugt wird, fur beide Geschlechter gleichermassen attraktiv ist, kann diese Studie diese Geschlechtsneutralitat von Englisch nicht bestatigen. Nach nur 8-9 Monaten Kontakt mit der englischen Sprache in der 3. Klasse sind die Madchen in dieser Studie signifikant motivierter Englisch zu lernen als die Jungen. Es ist erstaunlich und zu einem gewissen Grad auch beunruhigend, dass solche Geschlechterunterschiede bereits so fruh und vom Beginn des Sprachlernprozesses an zu existieren scheinen. Jegliche Versuche, die Sprachlernmotivation der Jungen in diesen fruhen Jahren zu fordern, mussen sich auf Erklarungsfaktoren dieses Motivationsdefizites stutzen. Vier solche Erklarungsfaktoren werden in dieser Studie aufgezeigt: das Selbstkonzept der Lernenden, ihre Einstellungen gegenuber der Sprache, Zielsprachensprechern und -landern, sowie ihre stereotypen Annahmen uber das Sprachenlernen. Die Jungen unterscheiden sich in Bezug auf alle vier Faktoren von den Madchen. Deshalb sollten sich Versuche, die Sprachlernmotivation der Jungen zu fordern, auf diese vier Faktoren konzentrieren. Stichworte: Sprachlernmotivation, Geschlechterunterschiede, Spracheinstellungen, Annahmen uber das Sprachenlernen, Selbstkonzept
Validation of Risk Assessment Models for Predicting the Incidence of Breast Cancer in Korean Women

Purpose The Gail model is one of the most widely used tools to assess the risk of breast cancer. However, it is known to overestimate breast cancer risk for Asian women. Here, we validate the Gail model and the Korean model using Korean data, and subsequently update and revalidate the Korean model using recent data. Methods We validated the modified Gail model (model 2), Asian American Gail model, and a previous Korean model using screening patient data collected between January 1999 and July 2004. The occurrence of breast cancer was confirmed by matching the resident registration number with data from the Korean Breast Cancer Registration Program. The expected-to-observed (E/O) ratio was used to validate the reliability of the program, and receiver operating characteristics curve analysis was used to evaluate the program's discriminatory power. There has been a rapid increase in the incidence of breast cancer in Korea, and we updated and revalidated the Korean model using incidence and mortality rate data from recent years. Results Among 40,229 patients who were included in the validation, 161 patients were confirmed to have developed breast cancer within 5 years of screening. The E/O ratios and 95% confidence intervals (CI) were 2.46 (2.10-2.87) for the modified Gail model and 1.29 (1.11-1.51) for the Asian American Gail model. The E/O ratio and 95% CI for the Korean model was 0.50 (0.43-0.59). For the updated Korean model, the E/O ratio and 95% CI were 0.85 (0.73-1.00). In the discriminatory power, the area under curve and 95% CI of the modified Gail model, Asian American Gail model, Korean model and updated Korean model were 0.547 (0.500-0.594), 0.543 (0.495-0.590), 0.509 (0.463-0.556), and 0.558 (0.511-0.605), respectively. Conclusion The updated Korean model shows a better performance than the other three models. It is hoped that this study can provide the basis for a clinical risk assessment program and a future prospective study of breast cancer prevention.
Nuclear Localization of COX-2 in relation to the Expression of Stemness Markers in Urinary Bladder Cancer

Inflammation may activate stem cells via prostaglandin E2 (PGE2) production mediated by cyclooxygenase-2 (COX-2) expression. We performed an immunohistochemical analysis of the expression of stemness markers (Oct3/4 and CD44v6) and COX-2 in urinary bladder tissues obtained from cystitis and cancer patients with and without Schistosoma haematobium infections. Immunoreactivity to Oct3/4 was significantly higher in S. haematobium-associated cystitis and cancer tissues than in normal tissues. CD44v6 expression was significantly higher in bladder cancer without S. haematobium than in normal tissues. COX-2 was located in the cytoplasmic membrane, cytoplasm, and nucleus of the cancer cells. Interestingly, the nuclear localization of COX-2, which was reported to function as a transcription factor, was significantly associated with the upregulation of Oct3/4 and CD44v6 in bladder cancer tissues with and without S. haematobium infection, respectively. COX-2 activation may be involved in inflammation-mediated stem cell proliferation/differentiation in urinary bladder carcinogenesis.
Killing monsters: Why children need fantasy, super heroes, and make-believe violence / Gerard Jones

Children choose their heroes more carefully than we think. From Pokemon to the rapper Eminem, pop-culture icons are not simply commercial pied pipers who practice mass hypnosis on our youth. Indeed, argues the author of this lively and persuasive paean to the power of popular culture, even trashy or violent entertainment gives children something they need, something that can help both boys and girls develop in a healthy way. Drawing on a wealth of true stories, many gleaned from the fascinating workshops he conducts, and basing his claims on extensive research, including interviews with psychologists and educators, Gerard Jones explains why validating our children's fantasies teaches them to trust their own emotions and build stronger selves.
Massive Thymic Deletion Results in Systemic Autoimmunity through Elimination of CD4+ CD25+ T Regulatory Cells

Incomplete deletion of KRN T cells that recognize the ubiquitously expressed self-antigen glucose-6-phosphate-isomerase (GPI) initiates an anti-GPI autoimmune cascade in K/BxN mice resulting in a humorally mediated arthritis. Transgenic (Tg) expression of a KRN T cell receptor (TCR) agonist under the major histocompatibility complex class II promoter resulted in thymic deletion with loss of anti-GPI T and B cell responses and attenuated arthritis course. However, double Tg mice succumbed to systemic autoimmunity with multiorgan inflammation and autoantibody production. Extensive thymic deletion resulted in lymphopenia and elimination of CD4+ CD25+ regulatory T cells (Tregs), but spared some CD4+ T cells expressing endogenous TCR, which oligoclonally expanded in the periphery. Disease was transferred by these T cells and prevented by cotransfer of CD4+ CD25+ Tregs. Moreover, we extended our findings to another TCR system (anti–hen egg lysozyme [HEL] TCR/HEL mice) where similarly extensive thymic deletion also resulted in disease. Thus, our studies demonstrated that central tolerance can paradoxically result in systemic autoimmunity through differential susceptibility of Tregs and autoreactive T cells to thymic deletion. Therefore, too little or too much negative selection to a self-antigen can result in systemic autoimmunity and disease.
Measuring intellectual capital: a new model and empirical study

The groundwork of intellectual capital (IC) management, measuring IC, attracts much attention from academics and practitioners. The purpose of this paper is to design a measurement model and a qualitative index system of IC, so as to provide a good tool for enterprises to manage their IC. Based on a review of several IC measurement models proposed by western researchers, IC is classified into human capital, structural capital, innovation capital and customer capital, and thereupon a qualitative index system for the above four IC elements is designed through an analysis of their contents. Through an empirical study, it is found that there is a significant relationship between the scores of the four IC elements of a company and its business performance, which proves the validity and rationality of the IC measurement model and the qualitative index system. In the meantime, the empirical study further proves that there is a remarkable relationship between the four IC elements. Therefore enterprises must manage and improve their IC from an integrative perspective.
Cognitive Work Analysis

Cognitive Work Analysis (Vicente, 1999) is a work-centered conceptual framework developed by Rasmussen, Pejtersen & Goodstein (1994) to analyze cognitive work. The purpose of Cognitive Work Analysis (CWA) is to guide the design of technology for use in the work place. It is unique because of its ability to analyze real-life phenomena while retaining the complexity inherent in them. When applied to information behavior, the approach guides the analysis of human-information interaction in order to inform the design of information systems.
Estrogen Receptors Alpha and Beta in Male and Female Gerbil Prostates1

ABSTRACT The Mongolian gerbil (Meriones unguiculatus, Gerbilinae: Muridae) is useful for prostate studies, because both males and females spontaneously develop prostatic disorders with age. Estrogens regulate prostate homeostasis via two estrogen receptors, ER alpha (ESR1) and ER beta (ESR2), but the cellular distribution and regulation of these receptors in the gerbil prostate has not been described. Both receptors were localized by immunohistochemistry in the ventral prostate of intact male and female gerbils, in males 7 and 21 days after castration, and in females treated with testosterone for 7 and 21 days. In male and female adult gerbils, ER alpha was detected mainly in prostatic stromal cells, whereas ER beta was present mostly in secretory and basal cells. More ER alpha-positive stromal cells were found in females than in males, as was a reduction toward the male value in females treated with testosterone. Castration did not alter ER alpha expression. Testosterone was necessary for maintenance of ER beta in the male prostate epithelium: ER beta expression declined markedly in prostates of males older than 1 yr, and castration of 4-mo-old males caused a reduction in ER beta to levels seen in 1-yr-old males. Because ER beta is an antiproliferative receptor, its loss with age may predispose the aging gerbil to proliferative diseases of the prostate.
Spontaneous Facial Expressions in Congenitally Blind and Sighted Children Aged 8–11

This study found that the emotional facial expressions of 10 congenitally blind and 10 sighted children, aged 8–11, were similar. However, the frequency of certain facial movements was higher in the blind children than in the sighted children, and social influences were evident only in the expressions of the sighted children, who often masked their negative emotions.
Clinical audit of the management of stable ankle fractures.

INTRODUCTION Ankle fractures are common and 'stable' ankle fractures comprise 40-75% of this group. Studies show that these injuries can be managed successfully in a functional brace, with no need for further radiographs and minimal out-patient follow-up. We aimed to audit current practice and introduce change in order to improve treatment and produce financial savings. PATIENTS AND METHODS A retrospective 6-month audit was carried out to establish practice. Guidelines were then drawn up and widely distributed in the accident and emergency (A&E) and orthopaedic departments. These included criteria for diagnosis of stable ankle fractures, a management protocol for treatment of these injuries in a brace and also a follow-up algorithm in the out-patient clinic. A prospective 6-month audit was then carried out to assess the effectiveness of the guidelines. RESULTS Of patients presenting in the second 6-month period, 91% were managed in a functional brace. The mean number of out-patient follow-up appointments, weeks until discharge and repeat radiographs all decreased significantly (P < 0.05) after the implementation of the guidelines. The cost of treating a patient with a stable ankle fracture dropped from 310.75 pounds to 129.80 pounds. CONCLUSIONS Previous studies have shown that stable ankle fractures are more effectively treated in a functional brace than a plaster cast, do not displace and, therefore, do not need repeat radiographs. A previous audit demonstrated that 60% of patients with stable fractures could be treated in a brace. We have shown that, with effective and persistent education of colleagues, the vast majority (91%) of patients can be managed in this way and this results in a significant cost saving. We have also shown that an evidence-based treatment protocol can produce significant improvements in management for patients and savings for healthcare organisations.
The evolution, metabolism and functions of the apicoplast

The malaria parasite, Plasmodium falciparum, harbours a relict plastid known as the ‘apicoplast’. The discovery of the apicoplast ushered in an exciting new prospect for drug development against the parasite. The eubacterial ancestry of the organelle offers a wealth of opportunities for the development of therapeutic interventions. Morphological, biochemical and bioinformatic studies of the apicoplast have further reinforced its ‘plant-like’ characteristics and potential as a drug target. However, we are still not sure why the apicoplast is essential for the parasite's survival. This review explores the origins and metabolic functions of the apicoplast. In an attempt to decipher the role of the organelle within the parasite we also take a closer look at the transporters decorating the plastid to better understand the metabolic exchanges between the apicoplast and the rest of the parasite cell.
A New Saurolophine Dinosaur from the Latest Cretaceous of Far Eastern Russia

Background Four main dinosaur sites have been investigated in latest Cretaceous deposits from the Amur/Heilongjiang Region: Jiayin and Wulaga in China (Yuliangze Formation), Blagoveschensk and Kundur in Russia (Udurchukan Formation). More than 90% of the bones discovered in these localities belong to hollow-crested lambeosaurine saurolophids, but flat-headed saurolophines are also represented: Kerberosaurus manakini at Blagoveschensk and Wulagasaurus dongi at Wulaga. Methodology/Principal Findings Herein we describe a new saurolophine dinosaur, Kundurosaurus nagornyi gen. et sp. nov., from the Udurchukan Formation (Maastrichtian) of Kundur, represented by disarticulated cranial and postcranial material. This new taxon is diagnosed by four autapomorphies. Conclusions/Significance A phylogenetic analysis of saurolophines indicates that Kundurosaurus nagornyi is nested within a rather robust clade including Edmontosaurus spp. , Saurolophus spp. , and Prosaurolophus maximus, possibly as a sister-taxon for Kerberosaurus manakini also from the Udurchukan Formation of Far Eastern Russia. The high diversity and mosaic distribution of Maastrichtian hadrosaurid faunas in the Amur-Heilongjiang region are the result of a complex palaeogeographical history and imply that many independent hadrosaurid lineages dispersed without any problem between western America and eastern Asia at the end of the Cretaceous.
Effectiveness of Implant Therapy Analyzed in a Swedish Population

Peri-implantitis is an inflammatory disease affecting soft and hard tissues surrounding dental implants. As the global number of individuals that undergo restorative therapy through dental implants increases, peri-implantitis is considered as a major and growing problem in dentistry. A randomly selected sample of 588 patients who all had received implant-supported therapy 9 y earlier was clinically and radiographically examined. Prevalence of peri-implantitis was assessed and risk indicators were identified by multilevel regression analysis. Forty-five percent of all patients presented with peri-implantitis (bleeding on probing/suppuration and bone loss >0.5 mm). Moderate/severe peri-implantitis (bleeding on probing/suppuration and bone loss >2 mm) was diagnosed in 14.5%. Patients with periodontitis and with ≥4 implants, as well as implants of certain brands and prosthetic therapy delivered by general practitioners, exhibited higher odds ratios for moderate/severe peri-implantitis. Similarly, higher odds ratios were identified for implants installed in the mandible and with crown restoration margins positioned ≤1.5 mm from the crestal bone at baseline. It is suggested that peri-implantitis is a common condition and that several patient- and implant-related factors influence the risk for moderate/severe peri-implantitis (ClinicalTrials.gov NCT01825772).
The Effect of Occupational Safety Legislation in Preventing Accidents at Work: Traditional versus Advanced Manufacturing Industries

We analyze the effect of occupational safety and health (OSH) legislation in reducing workplace accidents. It is argued that different impacts should be expected in advanced and traditional manufacturing sectors. We test this hypothesis with data on Spanish manufacturing throughout the period 1988–2004. To that effect, we estimate the relationship between the number of serious injuries and the potential risk factors, by means of diverse specifications of the negative binomial regression model for panel data. Our results indicate that, while the adoption of the new OSH regulation did contribute to the reduction in the number of injuries in advanced manufacturing sectors, the accident rates in traditional manufacturing did not show any statistically significant change following the reform.