Miracle-dz/UniFAR-FTUs huggingface dataset:
Qualitative and Quantitative Decline in Spermatogenesis of the Follicle-Stimulating Hormone Receptor Knockout (FORKO) Mouse1

Abstract Sertoli cells express functional receptors for FSH, one of the two pituitary hormones that regulate spermatogenesis in mammals. We recently produced genetic mutant (FORKO) mice that lack FSH receptor, in order to examine the effects on testicular function and fertility. Mutant males exhibited weight loss of testis, epididymis, and seminal vesicle as well as low levels of testosterone. Except for reduced seminiferous tubular diameter, no gross changes were apparent upon histological examination. Analysis of testicular germ cells by flow cytometry revealed a significant increase in the percentage of 2C cells (spermatogonia and non-germ cells) and a significant decrease in the percentage of HC cells (elongated spermatids) of FORKO males. The absolute number of homogenization-resistant elongated spermatids was also significantly reduced in the mutant males. A 2-fold increase in c-kit-positive 2C cells was recorded in the mutant males. Elongated spermatids of FORKO males showed a dramatic increase in propidium iodide binding suggesting reduced nuclear compaction. The increase in size of the sperm head in mutants, as well as susceptibility to dithiothreitol-induced decondensation, suggests the inadequate condensation of sperm chromatin. Sperm chromatin structure assay, a technique that reflects DNA stability, revealed that sperm from FORKO males are susceptible to acid denaturation, indicating the poor quality of sperm. These data allow us to conclude that genetic disruption of FSH receptor signaling in the rodent induces major changes that might contribute to reduced fertility.
A User-Centric View of Intelligent Environments: User Expectations, User Experience and User Role in Building Intelligent Environments

Our everyday environments are gradually becoming intelligent, facilitated both by technological development and user activities. Although large-scale intelligent environments are still rare in actual everyday use, they have been studied for quite a long time, and several user studies have been carried out. In this paper, we present a user-centric view of intelligent environments based on published research results and our own experiences from user studies with concepts and prototypes. We analyze user acceptance and users’ expectations that affect users’ willingness to start using intelligent environments and to continue using them. We discuss user experience of interacting with intelligent environments where physical and virtual elements are intertwined. Finally, we touch on the role of users in shaping their own intelligent environments instead of just using ready-made environments. People are not merely “using” the intelligent environments but they live in them, and they experience the environments via embedded services and new interaction tools as well as the physical and social environment. Intelligent environments should provide emotional as well as instrumental value to the people who live in them, and the environments should be trustworthy and controllable both by regular users and occasional visitors. Understanding user expectations and user experience in intelligent environments, and providing users with tools to influence the environments can help to shape the vision of intelligent environments into meaningful, acceptable and appealing service entities for all those who live and act in them.
A Randomized Controlled Trial of EEG-Based Motor Imagery Brain-Computer Interface Robotic Rehabilitation for Stroke

Electroencephalography (EEG)–based motor imagery (MI) brain-computer interface (BCI) technology has the potential to restore motor function by inducing activity-dependent brain plasticity. The purpose of this study was to investigate the efficacy of an EEG-based MI BCI system coupled with MIT-Manus shoulder-elbow robotic feedback (BCI-Manus) for subjects with chronic stroke with upper-limb hemiparesis. In this single-blind, randomized trial, 26 hemiplegic subjects (Fugl-Meyer Assessment of Motor Recovery After Stroke [FMMA] score, 4-40; 16 men; mean age, 51.4 years; mean stroke duration, 297.4 days), prescreened with the ability to use the MI BCI, were randomly allocated to BCI-Manus or Manus therapy, lasting 18 hours over 4 weeks. Efficacy was measured using upper-extremity FMMA scores at weeks 0, 2, 4 and 12. ElEG data from subjects allocated to BCI-Manus were quantified using the revised brain symmetry index (rBSI) and analyzed for correlation with the improvements in FMMA score. Eleven and 15 subjects underwent BCI-Manus and Manus therapy, respectively. One subject in the Manus group dropped out. Mean total FMMA scores at weeks 0, 2, 4, and 12 weeks improved for both groups: 26.3 ± 10.3, 27.4 ± 12.0, 30.8 ± 13.8, and 31.5 ± 13.5 for BCI-Manus and 26.6 ± 18.9, 29.9 ± 20.6, 32.9 ± 21.4, and 33.9 ± 20.2 for Manus, with no intergroup differences (P = .51). More subjects attained further gains in FMMA scores at week 12 from BCI-Manus (7 of 11 [63.6%]) than Manus (5 of 14 [35.7%]). A negative correlation was found between the rBSI and FMMA score improvement (P = .044). BCI-Manus therapy was well tolerated and not associated with adverse events. In conclusion, BCI-Manus therapy is effective and safe for arm rehabilitation after severe poststroke hemiparesis. Motor gains were comparable to those attained with intensive robotic therapy (1,040 repetitions/session) despite reduced arm exercise repetitions using EEG-based MI-triggered robotic feedback (136 repetitions/session). The correlation of rBSI with motor improvements suggests that the rBSI can be used as a prognostic measure for BCI-based stroke rehabilitation.
Validation of a Multidimensional HR Flexibility Measure

Wright and Snell (1998) contend that HR flexibility is an important construct that may enable managers and management scholars to gain a greater understanding of the role of human resource management in enhancing firm performance. However, there is limited evidence regarding the psychometric properties of the measures that have been used to assess the HR flexibility construct and examine its effects. A primary objective of this study was to develop and validate a psychometrically sound measure of the HR flexibility construct. In this article, we present evidence of content validity/adequacy, internal consistency reliability, convergent validity, discriminant validity, and criterion-related validity that provides support for the use of this study’s multidimensional HR flexibility measure in subsequent empirical inquiries and theory testing efforts. Implications and limitations of this current research as well as avenues for future research are discussed.
Predisposing Factors for the Complications of Deep Neck Infection

Introduction: Cerumen is known as ear wax, produced regularly by cerumen and lipid secretary glands. Regarding the effect of Mazandaran province's humid weather on the prevalence of pathogenic microorganisms, this study was performed to determine the bacterial flora of the ear in patients with acute otitis externa and its comparison with healthy subjects. Materials and Methods: In this case-control study, cerumen was collected and cultured from 40 patients with clinically diagnosed acute otitis externa and 80 healthy controls. The data were finally analyzed using SPSS. Results: In the study group, Staphylococcus aureus (20.8%), Bacillus (18.9%) and Pseudomonas (11.3%) and in the control group Staphylococcus epidermidis (38.7%) and Diphtheroid (22.4%) were the most common bacteria, respectively. Conclusion: The isolated bacteria from cerumen of healthy subjects were totally different from those of acute otitis externa patients.
Questioning dominant entrepreneurship assumptions: the case of female ethnic minority entrepreneurs

The aim of this paper was to shake up the entrepreneurship ideal by problematizing what seems to have become naturalized, i.e. the ideologized tale of optimism associated with entrepreneurship. We have chosen a particular group of entrepreneurs (one usually and typically excluded in not only popular discourse but also in mainstream entrepreneurship literature), and we have chosen a typical Western society, one that firmly ascribes to neoliberal ideas. We have brought into play Dutch institutional stories with those of female ethnic entrepreneurs to see if these institutions sustain the presupposed view and to find out how these women consequently ‘deal’ with such presuppositions, and how and at what particular aspects they resist them. Since centre-margin positionalities are central to our investigations we have turned to deconstruction analysis as an inspirational source for our analysis. Our analysis portrays how the centred ideas about entrepreneurship and the positive powers attributed to it do not hold; it demonstrates the incoherence of this centre rather than confirming its position. We have been able to establish that the hegemonic, positive discourse on entrepreneurship in general and with women of ethnic minority origin specifically indeed resonates in these institutions' stories, mostly in its non-reflexivity and ideological prejudices.
PAPER Number sense in human infants

Four experiments used a preferential looking method to investigate 6-month-old infants’ capacity to represent numerosity in visual-spatial displays. Building on previous findings that such infants discriminate between arrays of eight versus 16 discs, but not eight versus 12 discs (Xu & Spelke, 2000), Experiments 1 and 2 investigated whether infants’ numerosity discrimination depends on the ratio of the two set sizes with even larger numerosities. Infants successfully discriminated between arrays of 16 versus 32 discs, but not 16 versus 24 discs, providing evidence that their discrimination shows the set-size ratio signature of numerosity discrimination in human adults, children and many non-human animals. Experiments 3 and 4 addressed a controversy concerning infants’ ability to discriminate large numerosities (observed under conditions that control for total filled area, array size and density, item size and correlated properties such as brightness: Brannon, 2002; Xu, 2003b; Xu & Spelke, 2000) versus small numerosities (not observed under conditions that control for total contour length: Clearfield & Mix, 1999). To investigate the sources of these differing findings, Experiment 3 tested infants’ large-number discrimination with controls for contour length, and Experiment 4 tested small-number discrimination with controls for total filled area. Infants successfully discriminated the large-number displays but showed no evidence of discriminating the small-number displays. These findings provide evidence that infants have robust abilities to represent large numerosities. In contrast, infants may fail to represent small numerosities in visualspatial arrays with continuous quantity controls, consistent with the thesis that separate systems serve to represent large versus small numerosities.
The beta-sheets of proteins, the biosynthetic relationships between amino acids, and the origin of the genetic code.

Two forces are generally hypothesised as being responsible for conditioning the origin of the organization of the genetic code: the physicochemical properties of amino acids and their biosynthetic relationships (relationships between precursor and product amino acids). If we assume that the biosynthetic relationships between amino acids were fundamental in defining the genetic code, then it is reasonable to expect that the distribution of physicochemical properties among the amino acids in precursor-product relationships cannot be random but must, rather, be affected by some selective constraints imposed by the structure of primitive proteins. Analysis shows that measurements representing the 'size' of amino acids, e.g. bulkiness, are specifically associated to the pairs of amino acids in precurso-product relationships. However, the size of amino acids cannot have been selected per se but, rather, because it reflects the beta-sheets of proteins which are, therefore, identified as the main adaptive theme promoting the origin of genetic code organization. Whereas there are no traces of the alpha-helix in the genetic code table. The above considerations make it necessary to re-examine the relationship linking the hydrophilicity of the dinucleoside monophosphates of anticodons and the polarity and bulkiness of amino acids. It can be concluded that this relationship seems to be meaningful only between the hydrophilicity of anticodons and the polarity of amino acids. The latter relationship is supposed to have been operative on hairpin structures, ancestors of the tRNA molecule. Moreover, it is on these very structures that the biosynthetic links between precursor and product amino acids might have been achieved, and the interaction between the hydrophilicity of anticodons and the polarity of amino acids might have had a role in the concession of codons (anticodons) from precursors to products.
Decreased hospital length of stay associated with presentation of cases at morning report with librarian support.

OBJECTIVE The research sought to determine whether case discussion at residents' morning report (MR), accompanied by a computerized literature search and librarian support, affects hospital charges, length of stay (LOS), and thirty-day readmission rate. METHODS This case-control study, conducted from August 2004 to March 2005, compared outcomes for 105 cases presented at MR within 24 hours of admission to 19,210 potential matches, including cases presented at MR and cases not presented at MR. With matching criteria of patient age (+/- 5 years), identical primary diagnosis, and secondary diagnoses (within 3 additional diagnoses) using International Classification of Diseases (ICD-9) codes, 55 cases were matched to 136 controls. Statistical analyses included Student's t tests, chi-squared tests, and nonparametric methods. RESULTS LOS differed significantly between matched MR cases and controls (3 days vs. 5 days, P < 0.024). Median total hospital charges were $7,045 for the MR group and $10,663 for the control group. There was no difference in 30-day readmission rate between the 2 groups. DISCUSSION/CONCLUSION Presentation of a case at MR, followed by the timely dissemination of the results of an online literature review, resulted in a shortened LOS and lower hospital charges compared with controls. MR, in association with a computerized literature search guided by the librarians, was an effective means for introducing evidence-based medicine into patient care practices.
Multimodal Semantic Learning from Child-Directed Input

Children learn the meaning of words by being exposed to perceptually rich situations (linguistic discourse, visual scenes, etc). Current computational learning models typically simulate these rich situations through impoverished symbolic approximations. In this work, we present a distributed word learning model that operates on child-directed speech paired with realistic visual scenes. The model integrates linguistic and extra-linguistic information (visual and social cues), handles referential uncertainty, and correctly learns to associate words with objects, even in cases of limited linguistic exposure.
ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents.

This document has been developed as an expert consensus document by the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA), in collaboration with the American Academy of Neurology (AAN), the American College of Physicians (ACP), the American Geriatrics Society (AGS), the American Society of Hypertension (ASH), the American Society of Nephrology (ASN), the American Society for Preventive Cardiology (ASPC), the Association of Black Cardiologists (ABC), and the European Society of Hypertension (ESH). Expert consensus documents are intended to inform practitioners, payers, and other interested parties of the opinion of ACCF and document cosponsors concerning evolving areas of clinical practice and/or technologies that are widely available or new to the practice community. Topics chosen for coverage by expert consensus documents are so designed because the evidence base, the experience with technology, and/or clinical practice are not considered sufficiently well developed to be evaluated by the formal ACCF/AHA practice guidelines process. Often the topic is the subject of considerable ongoing investigation. Thus, the reader should view the expert consensus document as the best attempt of the ACCF and document cosponsors to inform and guide clinical practice in areas where rigorous evidence may not yet be available or evidence to date is not widely applied to clinical practice. When feasible, expert consensus documents include indications or contraindications. Typically, formal recommendations are not provided in expert consensus documents as these documents do not formally grade the quality of evidence, and the provision of “Recommendations” is felt to be more appropriately within the purview of the ACCF/AHA practice guidelines. However, recommendations from ACCF/AHA practice guidelines and ACCF appropriate use criteria are presented where pertinent to the discussion. The writing committee is in agreement with these recommendations. Finally, some topics covered by expert consensus documents will be addressed subsequently by the ACCF/AHA …
Immediate Breast Reconstruction with SalineFilled Implants: No Interference with the Oncologic Outcome?

The possible adverse effects on cancer control due to immediate breast reconstruction have been addressed recently for both silicone‐filled implants and flap reconstruction. To evaluate those possible effects after immediate breast reconstruction with saline‐filled implants, 49 patients reconstructed with saline‐filled breast implants at the Jules Bordet Cancer Institute were studied. Selection was only based on the possibility to find a matched patient. These patients were matched with a control group of 49 matched women with breast cancer treated in the same center by mastectomy without any type of breast reconstruction. The two groups were comparable according to age at diagnosis (within 3 years), year of diagnosis (same year), stage of the tumor, histology, and nodal status. The only difference between the two groups was that radiation therapy was applied to some of the patients who were not reconstructed (due to tumor location). The results show, in terms of local recurrences, distant metastasis, and deaths, no significant difference between the two groups, even for the irradiated patients, within a mean follow‐up period of 72 months (range, 24 to 108) months. (Plast. Reconstr. Surg. 107: 1409, 2001.)
Information Technology Acceptance in Health Information Management

Summary Objective: User acceptance of information technology has been a significant area of research for more than two decades in the field of information technology. This study assessed the acceptance of information technology in the context of Health Information Management (HIM) by utilizing Technology Acceptance Model (TAM) which was modified and applied to assess user acceptance of health information technology as well as viability of TAM as a research construct in the context of HIM. Methods: This was a descriptive- analytical study in which a sample of 187 personnel from a population of 363 personnel, working in medical records departments of hospitals affiliated to Tehran University of Medical Sciences, was selected. Users’ perception of applying information technology was studied by a researcher-developed questionnaire. Collected data were analyzed by SPSS software (version16) using descriptive statistics and regression analysis. Results: The results suggest that TAM is a useful construct to assess user acceptance of information technology in the context of HIM. The findings also evidenced the per -ceived ease of use (PEOU) and perceived usefulness (PE) were positively associated with favorable users’ attitudes towards HIM. PU was relatively more associated ( r= 0.22, p = 0.05) than PEOU (r = 0.014, p = 0.05) with favorable user attitudes towards HIM. Conclusions: Users’ perception of usefulness and ease of use are important determinants providing the incentive for users to accept information technologies when the application of a successful HIM system is attempted. The findings of the present study suggest that user acceptance is a key element and should subsequently be the major concern of health organizations and health policy makers.
Implementation of an Electronic Monitoring and Evaluation System for the Antiretroviral Treatment Programme in the Cape Winelands District, South Africa: A Qualitative Evaluation

Background A pragmatic three-tiered approach to monitor the world’s largest antiretroviral treatment (ART) programme was adopted by the South African National Department of Health in 2010. With the rapid expansion of the programme, the limitations of the paper-based register (tier 1) were the catalyst for implementation of the stand-alone electronic register (tier 2), which offers simple digitisation of the paper-based register. This article engages with theory on implementation to identify and contextualise enabling and constraining factors for implementation of the electronic register, to describe experiences and use of the register, and to make recommendations for implementation in similar settings where standardisation of ART monitoring and evaluation has not been achieved. Methods We conducted a qualitative evaluation of the roll-out of the register. This comprised twenty in-depth interviews with a diverse sample of stakeholders at facility, sub-district, and district levels of the health system. Facility-level participants were selected across five sub-districts, including one facility per sub-district. Responses were coded and analysed using a thematic approach. An implementation science framework guided interpretation of the data. Results & Discussion We identified the following seven themes: 1) ease of implementation, 2) perceived value of an electronic M&E system, 3) importance of stakeholder engagement, 4) influence of a data champion, 5) operational and logistical factors, 6) workload and role clarity, and 7) importance of integrating the electronic register with routine facility monitoring and evaluation. Interpreting our findings through an implementation theory enabled us to construct the scaffolding for implementation across the five facility-settings. This approach illustrated that implementation was not a linear process but occurred at two nodes: at the adoption of the register for roll-out, and at implementation at facility-level. Conclusion In this study we found that relative advantage of an intervention and stakeholder engagement are critical to implementation. We suggest that without these aspects of implementation, formative and summative outcomes of implementation at both the adoption and coalface stages of implementation would be negatively affected.
Exploring Joint Neural Model for Sentence Level Discourse Parsing and Sentiment Analysis

Discourse Parsing and Sentiment Analysis are two fundamental tasks in Natural Language Processing that have been shown to be mutually beneficial. In this work, we design and compare two Neural Based models for jointly learning both tasks. In the proposed approach, we first create a vector representation for all the text segments in the input sentence. Next, we apply three different Recursive Neural Net models: one for discourse structure prediction, one for discourse relation prediction and one for sentiment analysis. Finally, we combine these Neural Nets in two different joint models: Multi-tasking and Pre-training. Our results on two standard corpora indicate that both methods result in improvements in each task but Multi-tasking has a bigger impact than Pre-training. Specifically for Discourse Parsing, we see improvements in the prediction of the set of contrastive relations.