Miracle-dz/UniFAR-FTUs huggingface dataset:
Prominent Aspect Term Extraction in Aspect Based Sentiment Analysis

In recent years unstructured text has flooded on the web and today it is a trend to comments, give feedback, share experiences toward products, articles, social issues, multimedia web documents etc. Most of the online social, as well as, commercial platform have started to provide separate space for user reviews in the form of natural text. This electronic data is becoming very crucial and popular in decision making. Nowadays, sentiment analysis is not a onetime put effort rather it is more important to know about different aspects mentioned in the user comments. Aspect-term extraction is one of the critical subtasks in aspect-based sentiment analysis. Most of the aspect extraction approaches are the domain or context-dependent. In this paper, an approach is proposed to identify prominent aspects using contextual and domain-specific information. The study and experimental results on different categories of aspects are investigated on standard review data-sets.
Computer-mediated Collaborative Learning of Legal Argumentation

In this paper we review the role that collaborative learning can play in law. In particular, we see it as a constructive way of acquiring information not only about the domain, but also the processes that operate in the domain, and how to play the roles that arise in the domain. We have previously described a stand-alone dialogue tool to support such learning. In this paper we describe how the tool can be embedded in a more general environment which will support a variety of aspects of collaborative learning.
Dual or Mono Antiplatelet Therapy for Patients With Acute Ischemic Stroke or Transient Ischemic Attack: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background and Purpose— Antiplatelets are recommended for patients with acute noncardioembolic stroke or transient ischemic attack. We compared the safety and efficacy of dual versus mono antiplatelet therapy in patients with acute ischemic stroke or transient ischemic attack. Methods— Completed randomized controlled trials of dual versus mono antiplatelet therapy in patients with acute (⩽3 days) ischemic stroke/transient ischemic attack were identified using electronic bibliographic searches. The primary outcome was recurrent stroke (ischemic, hemorrhagic, unknown; fatal, nonfatal). Comparison of binary outcomes between treatment groups was analyzed with random effect models and described using risk ratios (95% CI). Results— Twelve completed randomized trials involving 3766 patients were included. In comparison with mono antiplatelet therapy, dual therapy (aspirin+dipyridamole and aspirin+clopidogrel) significantly reduced stroke recurrence, dual 58 (3.3%) versus mono 91 (5.0%; risk ratio, 0.67; 95% CI, 0.49–0.93); composite vascular event (stroke, myocardial infarction, vascular death), dual 74 (4.4%) versus mono 106 (6%; risk ratio, 0.75; 95% CI, 0.56–0.99); and the combination of stroke, transient ischemic attack, acute coronary syndrome, and all death, dual 100 (1.7%) versus mono 136 (9.1%; risk ratio, 0.71; 95% CI, 0.56–0.91); dual therapy was also associated with a nonsignificant trend to increase major bleeding, dual 15 (0.9%) versus mono 6 (0.4%; risk ratio, 2.09; 95% CI, 0.86–5.06). Conclusions— Dual antiplatelet therapy appears to be safe and effective in reducing stroke recurrence and combined vascular events in patients with acute ischemic stroke or transient ischemic attack as compared with mono therapy. These results need to be tested in prospective studies.
Hepatitis B virus‐regulated growth of liver cancer cells occurs through the microRNA‐340‐5p‐activating transcription factor 7‐heat shock protein A member 1B axis

Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis. Hepatitis B virus (HBV) is one of the leading causes of HCC, but the precise mechanisms by which this infection promotes cancer development are not fully understood. Recently, miR‐340‐5p, a microRNA (miRNA) that has been identified as a cancer suppressor gene, was found to inhibit the migration and invasion of liver cancer cells. However, the effect of miR‐340‐5p on cell proliferation and apoptosis in HBV‐associated HCC remains unknown. In our study, we show that miR‐340‐5p plays an important role during HBV infection and hepatocellular carcinoma development. Specifically, this miRNA directly binds to the mRNA encoding activating transcription factor 7 (ATF7), a protein that both promotes cell proliferation and suppresses apoptosis through its interaction with heat shock protein A member 1B (HSPA1B). We further found that miR‐340‐5p is downregulated by HBV, which enhances ATF7 expression, leading to enhanced cell proliferation and inhibition of apoptosis. Notably, ATF7 is upregulated in HCC tissue, suggesting that HBV may target miR‐340‐5p in vivo to promote ATF7/HSPA1B‐mediated proliferation and apoptosis and regulate liver cancer progression. This work helps to elucidate the complex interactions between HBV and host miRNAs and further suggests that miR‐340‐5p may represent a promising candidate for the development of improved therapeutic strategies for HCC.
Erectile dysfunction as a predictor of asymptomatic coronary artery disease in elderly men with type 2 diabetes

Erectile dysfunction (ED) and coronary artery disease (CAD) are closely linked, as both conditions share the same cardiovascular risk factors. [1] Indeed, these risk factors can determine endothelial dysfunction that represents the common underlying mechanism of both ED and CAD. [1],[2] The prevalence of ED is about three-fold higher among diabetic patients than in the general population[1],[3] and a higher prevalence of CAD has been observed in people with diabetes when compared to non-diabetic subjects. [3] Some studies showed that ED can be a powerful marker of silent CAD[4],[5] and a strong predictor of cardiovascular events in apparently uncomplicated type 2 diabetic patients. [6],[7] Therefore ED is now considered as a sentinel symptom of silent CAD, as ED often precedes the onset of myocardial ischemia itself by many years. [2],[8],[9] Silent CAD can worse the prognosis of diabetic patients and this suggests to identify diabetic patients at higher risk for silent CAD in order to early and effectively treat them. [10]–[13] Current guidelines suggest the screening for CAD when diabetic patients have some clinical conditions or at least two cardiovascular risk factors in addition to diabetes. [14] Unfortunately several studies showed that about 40% of diabetic patients with silent CAD can be missed on the basis of the current guidelines,[15],[16] but ED may interestingly improve sensitivity and specificity of guidelines for CAD screening when it is added to the common cardiovascular risk factors. [16] ED is the most frequently diagnosed sexual dysfunction in the older male population, especially after 70 years, even if it is often underreported and under-diagnosed in the elderly. [17] In addition, CAD prevalence increases with age. So it may be of great interest to understand whether ED remains a risk factor for silent CAD in elderly diabetic patients. To the best of our knowledge, no study has specifically investigated the role of ED as a predictor of silent CAD in type 2 diabetic elderly subjects. Therefore, the aim of the present study was to evaluate whether ED may be a marker of asymptomatic CAD also in elderly patients with diabetes.
Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism

Neuropathic syndromes which are evoked by lesions to the peripheral or central nervous system are extremely difficult to treat, and available drugs rarely joint an antihyperalgesic with a neurorestorative effect. N-Palmitoylethanolamine (PEA) exerts antinociceptive effects in several animal models and inhibits peripheral inflammation in rodents. Aimed to evaluate the antineuropathic properties of PEA, a damage of the sciatic nerve was induced in mice by chronic constriction injury (CCI) and a subcutaneous daily treatment with 30 mg kg−1 PEA was performed. On the day 14, PEA prevented pain threshold alterations. Histological studies highlighted that CCI induced oedema and an important infiltrate of CD86 positive cells in the sciatic nerve. Moreover, osmicated preparations revealed a decrease in axon diameter and myelin thickness. Repeated treatments with PEA reduced the presence of oedema and macrophage infiltrate, and a significant higher myelin sheath, axonal diameter, and a number of fibers were observable. In PPAR-α null mice PEA treatment failed to induce pain relief as well as to rescue the peripheral nerve from inflammation and structural derangement. These results strongly suggest that PEA, via a PPAR-α-mediated mechanism, can directly intervene in the nervous tissue alterations responsible for pain, starting to prevent macrophage infiltration.
Signature of Electron Capture in Iron-rich Ejecta of SN 2003du

Late-time near-infrared and optical spectra of the normal-bright Type Ia supernova 2003du about 300 days after the explosion are presented. At this late epoch, the emission profiles of well-isolated [Fe II] lines (in particular that of the strong 1.644 μm feature) trace out the global kinematic distribution of radioactive material in the expanding supernova ejecta. In SN 2003du, the 1.644 μm [Fe II] line seems to show a flat-topped profile, indicative of a thick but hollow-centered expanding shell, rather than a strongly peaked profile that would be expected from a "center-filled" distribution. Based on detailed models for exploding Chandrasekhar-mass white dwarfs, we show that the feature is consistent with spherical explosion models. Our model predicts a central region of nonradioactive electron capture elements up to 2500-3000 km s-1 as a consequence of burning under high density and an extended region of radioactive 56Ni up to 9000-10,000 km s-1. Furthermore, our analysis indicates that the 1.644 μm [Fe II] line profile is not consistent with strong mixing between the regions of electron-capture isotopes and the 56Ni layers, as is predicted by detailed three-dimensional models for nuclear deflagration fronts. We discuss the possibility that the flat-topped profile could be produced as a result of an infrared catastrophe and conclude that such an explanation is unlikely. We discuss the limitations of our analysis and place our results into context by comparison with constraints on the distribution of radioactive 56Ni in other SNe Ia and briefly discuss the potential implications of our result for the use of SNe Ia as cosmological standard candles.
Treatment of Relapsing Paralysis in Experimental Encephalomyelitis by Targeting Th1 Cells through Atorvastatin

Statins, known as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, exhibit numerous functions related to inflammation, such as MHC class II down-regulation, interference with T cell adhesion, and induction of apoptosis. Here we demonstrate that both subcutaneous and oral administration of atorvastatin inhibit the development of actively induced chronic experimental autoimmune encephalomyelitis in SJL/J mice and significantly reduce the inflammatory infiltration into the central nervous system (CNS). When treatment was started after disease onset, atorvastatin reduced the incidence of relapses and protected from the development of further disability. Both the reduced autoreactive T cell response measured by proliferation toward the encephalitogenic peptide PLP139–151 and the cytokine profile indicate a potent blockade of T helper cell type 1 immune response. In in vitro assays atorvastatin not only inhibited antigen-specific responses, but also decreased T cell proliferation mediated by direct TCR engagement independently of MHC class II and LFA-1. Inhibition of proliferation was not due to apoptosis induction, but linked to a negative regulation on cell cycle progression. However, early T cell activation was unaffected, as reflected by unaltered calcium fluxes. Thus, our results provide evidence for a beneficial role of statins in the treatment of autoimmune attack on the CNS.
Phase I/Ib study of olaparib and carboplatin in heavily pretreated recurrent high-grade serous ovarian cancer at low genetic risk

Purpose: To investigate maximum tolerated dose (MTD), activity and predictive biomarkers of olaparib with carboplatin in BRCA wild-type (BRCAwt) high grade serous ovarian carcinoma (HGSOC) patients. Methods: A 3+3 dose escalation study examined olaparib capsules (400 mg twice daily [BID], days 1–7) with carboplatin (AUC3-5 on day 1) every 21 days for 8 cycles, followed by olaparib 400 mg BID maintenance. Blood and tumor biopsy samples were collected pre- and on-treatment in the expansion cohort for PAR levels and proteomic endpoints. Results: 30 patients (median 7 prior regimens [2–12], 63% (19/30) platinum-resistant) were enrolled. Dose-limiting toxicity was thrombocytopenia/neutropenia, and infection with carboplatin AUC5 (2/6 patients). MTD was olaparib 400 mg BID + carboplatin AUC4. Grade 3/4 adverse events (>10%) included neutropenia (23%), thrombocytopenia (20%), and anemia (13%). Five of 25 (20%) evaluable patients had partial response (PR; median 4.5 months [3.3–9.5]). Clinical benefit rate (PR + stable disease ≥4 months) was 64% (16/25). A greater decrease in tissue PAR levels was seen in the clinical benefit group versus no benefit (median normalized linear change −1.84 [−3.39– −0.28] vs 0.51 [−0.27– 1.29], p = 0.001) and a DNA repair score by proteomics did not correlate with response. Conclusions: The olaparib and carboplatin combination is tolerable and has clinical benefit in subsets of heavily pretreated BRCAwt HGSOC, independent of platinum sensitivity.
The CobraPLA™ During Anesthesia with Controlled Ventilation: A Clinical Trial of Efficacy

The CobraPLA™ (CPLA) is a relatively new supraglottic airway device that has not been sufficiently investigated. Here, we performed a prospective observational study to evaluate the efficacy of the CPLA during controlled ventilation. In 50 anesthetized and paralyzed patients undergoing elective surgery a CPLA was inserted and inflated to an intracuff pressure of 60 cm H2O. The success rate of insertion upon the first attempt was 82% (41/50), with a mean insertion time of 16.3 ± 4.5 seconds. The adequacy of ventilation was assessed by observing the end tidal CO2 waveform, movement of the chest wall, peak airway pressure (13.5 cm H2O), and leak fraction (4%). We documented the airway sealing pressure (22.5 cm H2O) and noted that the the site of gas leaks at that pressure were either at the neck (52%), the abdomen (46%), or both (2%). In 44 (88%) patients, the vocal cords were visible in the fiberoptic view through the CPLA. There was no gastric insufflation during the anesthesia. Respiratory and hemodynamic parameters remained stable during CPLA insertion. Postoperative blood staining of CPLA was minimal, occurring in 22% (11/50) of patients. Mild and moderate throat soreness was reported in 44% (22/50) and 4% (2/50) of patients, respectively. Lastly, mild dysphonia was observed in 6% (3/50) of patients and mild dysphagia in 10% (5/50) of patients. Our results indicated that the CPLA is both easy to place and allows adequate ventilation during controlled ventilation.
Selecting parameters of SVM using meta-learning and kernel matrix-based meta-features

The Support Vector Machine (SVM) algorithm is sensitive to the choice of parameter settings, which makes it hard to use by non-experts. It has been shown that meta-learning can be used to support the selection of SVM parameter values. Previous approaches have used general statistical measures as meta-features. Here we propose a new set of meta-features that are based on the kernel matrix. We test them on the problem of setting the width of the Gaussian kernel for regression problems. We obtain significant improvements in comparison to earlier meta-learning results. We expect that with better support in the selection of parameter values, SVM becomes accessible to a wider range of users.
Amygdala lesions do not compromise the cortical network for false-belief reasoning

Significance Humans use a so-called “theory-of-mind” to reason about the beliefs of others. Neuroimaging studies of belief reasoning suggest it activates a specific cortical network. The amygdala is interconnected with this network and plays a fundamental role in social behavior. For the first time, to our knowledge, we test whether amygdala lesions compromise the cortical implementation of theory-of-mind. Two patients with bilateral amygdala lesions performed a belief reasoning test while undergoing functional MRI. Remarkably, both patients showed typical test performance and cortical activity when compared with nearly 500 healthy controls. This result shows that the amygdala is not a necessary part of theory-of-mind function in adulthood and forces a reevaluation of the amygdala’s role in social cognition. The amygdala plays an integral role in human social cognition and behavior, with clear links to emotion recognition, trust judgments, anthropomorphization, and psychiatric disorders ranging from social phobia to autism. A central feature of human social cognition is a theory-of-mind (ToM) that enables the representation other people's mental states as distinct from one's own. Numerous neuroimaging studies of the best studied use of ToM—false-belief reasoning—suggest that it relies on a specific cortical network; moreover, the amygdala is structurally and functionally connected with many components of this cortical network. It remains unknown whether the cortical implementation of any form of ToM depends on amygdala function. Here we investigated this question directly by conducting functional MRI on two patients with rare bilateral amygdala lesions while they performed a neuroimaging protocol standardized for measuring cortical activity associated with false-belief reasoning. We compared patient responses with those of two healthy comparison groups that included 480 adults. Based on both univariate and multivariate comparisons, neither patient showed any evidence of atypical cortical activity or any evidence of atypical behavioral performance; moreover, this pattern of typical cortical and behavioral response was replicated for both patients in a follow-up session. These findings argue that the amygdala is not necessary for the cortical implementation of ToM in adulthood and suggest a reevaluation of the role of the amygdala and its cortical interactions in human social cognition.
A fingerprint cryptosystem based on minutiae phase spectrum

Public acceptance of biometric technology is hindered by security and privacy concerns regarding leakage of biometric templates. Biometric cryptosystems alleviate this problem by storing a secure sketch that is typically derived by binding the template with a cryptographic key. However, designing fingerprint cryptosystems is difficult because fingerprint matching is usually based on unordered sets of minutia features having large intra-user variations. To overcome this challenge, we propose a novel minutiae representation known as the Binarized Phase Spectrum (BiPS), which is a fixed-length binary string obtained by quantizing the Fourier phase spectrum of a minutia set. We secure the BiPS representation using a fuzzy commitment scheme employing turbo codes. We also propose a technique for aligning fingerprints based on the focal point of high curvature regions. The proposed system achieves a FNMR of 16.2% and 12.6% on FVC2002-DB1 and DB2 databases, respectively, at zero FMR.
Predictors of Quality of Life in Infertile Couples

Objectives This study was conducted with the aim of examines the quality of life of infertile couples and their relationship with the practical resilience of infertile couples referring to Yazd's centers of infertility. Methods This research is a descriptive-correlational study. The research population consisted of all infertile couples who referred to Infertility Centers in Yazd, Iran in the winter of 2016. Sampling was conducted in a non-random and accessible manner. The instrument used in the research included a) demographic information questionnaire, b) Conner and Davidson's Resilience Scale, and c) quality of life infertile couples questionnaire. Data were analyzed by SPSS software version 17 at a significant level of P < 0.05. To describe the data, descriptive statistics methods were used and the inferential statistics (Pearson correlation coefficient, regression, independent t test, and variance analysis) were used to test the research hypotheses. Results People (202 couples) participated in this research. Three variables of resilience (β = 0.04, P = 0.04), gender (β = −0.22, P < 0.001), and education level (β = 0.21, P < 0.001) had a prediction coefficient and there was a significant relationship with quality of life. Conclusions This study showed that resilience, gender, and education predict the quality of life of infertile couples. In the infertile couples counseling program, resilience should be considered as a coping factor.
Explorer A zebrafish live imaging model reveals differential responses of microglia towards glioblastoma cells in vivo

Glioblastoma multiforme is the most common and deadliest form of brain cancer. Glioblastomas are infiltrated by a high number of microglia, which promote tumor growth and surrounding tissue invasion. However, it is unclear how microglia and glioma cells physically interact and if there are differences, depending on glioma cell type. Hence, we have developed a novel live imaging assay to study microglia–glioma interactions in vivo in the zebrafish brain. We transplanted well-established human glioblastoma cell lines, U87 and U251, into transgenic zebrafish lines with labelled macrophages/microglia. Our confocal live imaging results show distinct interactions between microglia and U87, as well as U251 glioblastoma cells that differ in number and nature. Importantly these interactions do not appear to be antitumoral as zebrafish microglia do not engulf and phagocytose the human glioblastoma cells. Finally, xenotransplants into the irf8 zebrafish mutant that lacks microglia, as well as pharmacological inhibition of the CSF-1 receptor (CSF-1R) on microglia, confirm a prominent role for zebrafish microglia in promoting human glioblastoma cell growth. This new model will be an important tool for drug screening and the development of future immunotherapeutics targeting microglia within glioma.