Miracle-dz/UniFAR-FTUs huggingface dataset:
Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus.

OBJECTIVE To examine protein oxidation in systemic lupus erythematosus (SLE) and to correlate levels of protein oxidation products with disease activity. METHODS Serum was collected from SLE patients and healthy control subjects. Protein-bound carbonyls and the pro-oxidant enzyme myeloperoxidase (MPO) were quantified by enzyme-linked immunosorbent assay. Protein thiols were quantified using 5,5'-dithionitrobenzoic acid. Protein-bound amino acids and methionine, tyrosine, and phenylalanine oxidation products were quantified by acid hydrolysis and high-performance liquid chromatography. Disease activity was assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Levels of anti-double-stranded DNA (anti-dsDNA) antibodies were measured by radioimmunoassay. RESULTS Compared with control subjects, SLE patients exhibited elevated levels of protein carbonyls (0.108 +/- 0.078 versus 0.064 +/- 0.028 nmoles/mg of protein; P = 0.046), decreased levels of protein thiols (3.9 +/- 1.1 versus 4.9 +/- 0.7 nmoles/mg of protein; P = 0.003), decreased levels of protein-bound methionine (P = 0.0007), and increased levels of protein-bound methionine sulfoxide (P = 0.0043) and 3-nitrotyrosine (P = 0.0477). SLE patients with high SLEDAI scores or elevated anti-dsDNA antibody levels exhibited increased oxidation compared with patients with low SLEDAI scores or low antibody levels. Serum MPO levels were decreased in SLE patients (P = 0.03), suggesting that this enzyme is not responsible for the enhanced protein oxidation. CONCLUSION We found elevated levels of multiple markers of protein oxidation in sera from SLE patients compared with controls, and these levels correlated with disease activity. The findings suggest that protein oxidation may play a role in the pathogenesis of chronic organ damage in SLE.
Mechanisms of Virus Pathogenicity

INTRODUCTION . 291 QUANTITATIVE COMPARISONS OF VIRULENCE: PROPERTIES OF VIRULENT AND ATTENUATED STRAINS . 292 ENTRY OF THE HOST: SURVIVAL ON AND PENETRATION OF MUCOUS MEMBRANES . 292 REPLICATION IN VIVO . 294 COUNTERACTING HOST DEFENSE MECHANISMS . 295 HOST DAMAGE. 298 HOST AND TISSUE SPECIFICITY . 301 LITERATURE CITED . 305
Does symmetry Imply PPT Property?

Recently, in [1], the author proved that many results that are true for PPT matrices also hold for another class of matrices with a certain symmetry in their Hermitian Schmidt decompositions. These matrices were called SPC in [1] (definition 1.1). Before that, in [9], Toth and Guhne proved that if a state is symmetric then it is PPT if and only if it is SPC. A natural question appeared: What is the connection between SPC matrices and PPT matrices? Is every SPC matrix PPT? Here we show that every SPC matrix is PPT in $M_2\otimes M_2$ (theorem 4.3). This theorem is a consequence of the fact that every density matrix in $M_2\otimes M_m$, with tensor rank smaller or equal to 3, is separable (theorem 3.2). This theorem is a generalization of the same result found in [1] for tensor rank 2 matrices in $M_k\otimes M_m$. Although, in $M_3\otimes M_3$, there exists a SPC matrix with tensor rank 3 that is not PPT (proposition 5.2). We shall also provide a non trivial example of a family of matrices in $M_k\otimes M_k$, in which both, the SPC and PPT properties, are equivalent (proposition 6.2). Within this family, there exists a non trivial subfamily in which the SPC property is equivalent to separability (proposition 6.4).
Comorbidity and Phenomenology of Bipolar Disorder in Children With ADHD

Objective: To assess the comorbidity of bipolar disorder (BPD) in children with ADHD and to study the psychopathological profile of ADHD children with and without mania. Method: A total of 100 children with ADHD were assessed with a semistructured diagnostic interview and questionnaires of mania, ADHD, and general psychopathology. Results: 8% of children met criteria for BPD and 6% for BPD–not specified. ADHD children with bipolar spectrum disorder had greater comorbidity with disruptive behavior disorders and scored higher on the Young Mania Rating Scales and on the Child Behavior Checklist (CBCL) Scales of rule-breaking behavior, externalizing problems, and total problems; however, significance on the CBCL Scales was lost when controlling for disruptive behavior disorders. Conclusion: BPD is frequently associated with ADHD; it has important implications for prognosis and choice of treatment. Differences on the CBCL Scales could be explained by the comorbidity with disruptive behavior disorders rather than by a specific manic profile.
Listening to nonnative language which violates native assimilation rules

Recent studies using phoneme detection tasks have shown that spoken-language processing is neither facilitated nor interfered with by optional assimilation, but is inhibited by violation of obligatory assimilation. Interpretation of these results depends on an assessment of their generality, specifically, whether they also obtain when listeners are processing nonnative language. Two separate experiments are presented in which native listeners of German and native listeners of Dutch had to detect a target fricative in legal monosyllabic Dutch nonwords. All of the nonwords were correct realisations in standard Dutch. For German listeners, however, half of the nonwords contained phoneme strings which violate the German fricative assimilation rule. Whereas the Dutch listeners showed no significant effects, German listeners detected the target fricative faster when the German fricative assimilation was violated than when no violation occurred. The results might suggest that violation of assimilation rules does not have to make processing more difficult per se.
Spoken word processing and the effect of phonemic mismatch in aphasia

Background: There is evidence that, unlike in typical populations, initial lexical activation upon hearing spoken words in aphasic patients is not a direct reflection of the goodness of fit between the presented stimulus and the intended target. Earlier studies have mainly used short monosyllabic target words. Short words are relatively difficult to recognise because they are not highly redundant: changing one phoneme will often result in a (similar‐sounding) different word. Aims: The present study aimed to investigate sensitivity of the lexical recognition system in aphasia. The focus was on longer words that contain more redundancy, to investigate whether aphasic adults might be impaired in deactivation of strongly activated lexical candidates. This was done by studying lexical activation upon presentation of spoken polysyllabic pseudowords (such as procodile) to see to what extent mismatching phonemic information leads to deactivation in the face of overwhelming support for one specific lexical candidate. Methods & Procedures: Speeded auditory lexical decision was used to investigate response time and accuracy to pseudowords with a word‐initial or word‐final phonemic mismatch in 21 aphasic patients and in an age‐matched control group. Outcomes & Results: Results of an auditory lexical decision task showed that aphasic participants were less sensitive to phonemic mismatch if there was strong evidence for one particular lexical candidate, compared to the control group. Classifications of patients as Broca's vs Wernicke's or as fluent vs non‐fluent did not reveal differences in sensitivity to mismatch between aphasia types. There was no reliable relationship between measures of auditory verbal short‐term memory and lexical decision performance. Conclusions: It is argued that the aphasic results can best be viewed as lexical “overactivation” and that a verbal short‐term memory account is less appropriate.
Active shape models with SIFT descriptors and MARS

We present a technique for locating landmarks in images of human faces. We replace the 1D gradient profiles of the classical Active Shape Model (ASM) (Cootes and Taylor, 1993) with a simplified form of SIFT descriptors (Lowe, 2004), and use Multivariate Adaptive Regression Splines (MARS) (Friedman, 1991) for descriptor matching. This modified ASM is fast and performs well against existing techniques for automatic face landmarking on frontal faces.
Objectively Measured Physical Activity and Falls in Well-Functioning Older Adults: Findings From the Baltimore Longitudinal Study of Aging

Objective Previous work demonstrates the consequences of falling in older adults and the potential of physical activity (PA) to reduce falls, but few studies have used accelerometer-measured PA to compare overall and time-of-day activity patterns of nonfallers, fallers, or subgroups of fallers. Methods In 840 participants (mean age, 66.7; s = 13.2; range, 26–97) of the Baltimore Longitudinal Study of Aging between 2007 and 2014, PA was measured objectively with Actiheart accelerometers and falling status (faller/nonfaller) was assessed during an in-person interview. Differences in daily PA and PA by time-of-day were assessed using multiple linear regression. Differences in PA (multiple linear regression), and functional status (&khgr;2) were further examined in subgroups of “risky” or “normal” fallers. Results Overall, fallers and nonfallers exhibited similar daily (&bgr; = 22.6, P = 0.48) and time-specific PA; however, those who fell doing risky activities were more active overall (&bgr; = 243.8, P = 0.002), during the morning (&bgr; = 77.3, P = 0.004), afternoon (&bgr; = 78.4, P = 0.001), and late afternoon/evening (&bgr; = 56.3, P = 0.006) than those who fell doing normal activities. Risky fallers were significantly higher functioning than normal fallers. Conclusions Persons who fell while engaging in normal activities exhibited lower PA overall and throughout most of the day, and were of lower functional status than persons who fell while engaging in risky or unusual activities, suggesting that engagement in risky or unusual PA is associated with higher functional ability and lower falls risk in older persons.
Glycosphingolipid specificity of the human sulfatide activator protein.

The interaction of the sulfatide activator protein with different glycosphingolipids have been studied in detail. The following findings were made. 1. The sulfatide activator protein forms water-soluble complexes with sulfatides [Fischer, G. and Jatzkewitz, H. (1977) Hoppe-Seyler's Z. Physiol. Chem. 356, 6588-6591] and various other glycospingolipids. 2. In the absence of degrading enzymes the activator protein acts in vitro as a glycosphingolipid transfer protein, transporting glycosphingolipids from donor to acceptor liposomes. Lipids having less than three hexoses, e.g. galactosylceramide, sulfatide and ganglioside GM3 were transferred at very slow rates, whereas complex lipids such as gangliosides GM2, GM1 and GD1a were transferred much faster than the former. The transfer rate increased with increasing length of the carbohydrate chain of the lipid molecules. 3. Both the acyl residue in the ceramide moiety and the nature of the carbohydrate chain are significant for recognition of the glycosphingolipids by the sulfatide activator protein. Apparently, both residues serve as an anchor and the longer they are the better they are recognized by the protein. 4. In the absence of activator protein, degradation rates of sulfatide derivatives by arylsulfatase A, and of ganglioside GM1 derivatives by beta-galactosidase, increase with decreasing length of acyl residues in their hydrophobic ceramide moiety. Addition of activator protein stimulates the degradation of only those GM1 and sulfatide derivatives that have long-chain fatty acids in their hydrophobic ceramide anchor.
Association of a precore genomic variant of hepatitis B virus with fulminant hepatitis

A variant of hepatitis B virus has been described recently in HBsAg+ Mediterranean patients who lack HBeAg and who have an unusual and severe form of chronic hepatitis. This variant is unable to produce HBeAg because of the presence of a novel translational stop codon at the end of the precore region of the genome. By direct sequencing of DNA, generated by the polymerase chain reaction, we have evaluated the association between infection with this variant and the fulminant course of hepatitis B. Eighteen patients with fulminant hepatitis B were studied. Of the 15 cases from whose serum viral DNA could be sequenced, the variant was found in the admission sera of 8 of 9 HBeAg—patients but in none of 6 HBeAg+ patients who had fulminant hepatitis B. Patients harboring the variant progressed more rapidly into hepatic encephalopathy, but those infected with the variant strain alone had a greater likelihood of survival than those infected with the normal strain or a mixture. The mutant strain may emerge spontaneously during fulminant hepatitis as occurs in chronic hepatitis B infection during seroconversion from HBeAg to antibody. Alternately, and perhaps less commonly, patients may be infected with the variant ab initio. (HEPATOLOGY 1991;14:219–222.)
Autologous and allogeneic stem cell transplantation: rising therapeutic promise for mantle cell lymphoma

Mantle cell lymphoma (MCL) is currently an incurable neoplasm with a median survival duration of 3–5 years. The clinical results of therapy with cyclophosphamide, doxorubicin, vincristine, and prednisone or similar regimens are inadequate, leading to widespread exploration of the use of autologous stem cell transplantation (ASCT) during the first remission. In the pre-rituximab era, early ASCT extended the median remission duration by 1–2 years, but most patients eventually experienced relapse. With the advent of rituximab and its incorporation into stem cell mobilization and conditioning regimens, several research groups have reported improved outcomes, including the emergence of early survival curve plateaus that suggest a cured fraction. Intensive chemoimmunotherapy with rituximab and hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone has been reported to have similarly favorable results. Therefore, the addition of rituximab to intensive chemotherapy or ASCT regimens may be curative in patients undergoing frontline treatment for MCL. In the relapsed or refractory disease setting, the clinical results of ASCT remain inadequate. However, the increasing safety and high efficacy of non-myeloablative stem cell transplantation (SCT) suggests that it is the most appropriate transplantation modality in patients with relapsed or refractory MCL when a suitable donor is available.
The Dilemma of Reactive NS1 Antigen test in Dengue Fever.

Recently, two papers have been published on the phase 3 efficacy trial of the Indian rotavirus vaccine (Rotavac) [1,2]. The study sites were Delhi (urban), Pune (rural) and Vellore (urban and rural) [1,2]. A total of 4532 infants were assigned to vaccine group and 2267 to placebo group in this randomized, double-blind, placebo controlled study [1,2]. Vaccine efficacy (VE) against severe rotavirus gastroenteritis was 53.6 percent in the first year and 48.9 percent during the second year after vaccination [1,2]. These results are comparable to VE of the other licensed rotavirus vaccines in tropical developing countries [1,2].
Coherence of mind in daughter caregivers of mothers with dementia: Links with their mothers' joy and relatedness on reunion in a strange situation

This paper reports on a small sample (n = 17) of daughter caregivers of mothers with dementia who were interviewed with the Adult Attachment Interview, while their mothers stayed in an adjoining university room. Daughters were then reunited with their mothers, after a one-hour separation. Joyful and related ‘secure’ maternal behaviors, including proximity seeking, contact maintaining and overall responsiveness, were positively correlated with coherence of mind, and coherence of transcript ratings derived from the daughters' AAIs. Controlling for the severity of dementia in the mothers did not alter the power of these associations. Discussion addresses the lifelong significance of reunion behavior, the survival of ‘secure’ attachment behavior even into the late stages of dementia, and the clinical relevance of the Adult Attachment Interview.
Plant radiation history affects community assembly: evidence from the New Zealand alpine

The hypothesis that early plant radiations on islands dampen diversification and reduce habitat occupancy of later radiations via niche pre-emption has never, to our knowledge, been tested. We investigated clade-level dynamics in plant radiations in the alpine zone, New Zealand. Our aim was to determine whether radiations from older colonizations influenced diversification and community dominance of species from later colonizations within a common bioclimatic zone over the past ca 10 Myr. We used stem ages derived from the phylogenies of 17 genera represented in alpine plant communities in the Murchison Mountains, Fiordland, and assessed their presence and cover in 262 (5 × 5 m) vegetation plots. Our results show clear age-related community assembly effects, whereby congenerics from older colonizing genera co-occur more frequently and with greater cover per unit area than those from younger colonizing genera. However, we find no evidence of increased species richness with age of colonization in the alpine zone. The data support priority effects via niche pre-emption among plant radiations influencing community assembly.
Efficacy of Ultrasonography Guided Stellate Ganglion Blockade in the Stroke Patients with Complex Regional Pain Syndrome

Objective To compare the efficacy of ultrasonography guided stellate ganglion block (US-SGB) with that of blind SGB in management of the stroke patients with complex regional pain syndrome (CRPS) type 1. Method Forty-two patients with post-stroke CRPS were randomly assigned to either US-guided SGB (22 patients) or blind SGB group (20 patients). The mean age of US-guided SGB and blind SGB groups was 61.3±5.6 years and 59.1±4.5 years. We performed two blockades at 7-day intervals on the affected side of patients with CRPS. Pain intensity, using a visual analog score (VAS), score of CRPS clinical severity, and the amounts of affected hand swelling with a hand volumeter were assessed before, 2 weeks and 4 weeks after treatment. Results In both groups, VAS and the amount of hand swelling were significantly decreased after 2 weeks and after 4 weeks. Between two groups, VAS difference of US-guided SGB group and that of blind SGB group were 2.61±1.09, 1.88±0.62 at 2 weeks and 3.67±1.03, 3.13±0.62 at 4 weeks, respectively. US-guided SGB group showed more significant improvement in mean change of VAS compared to the blind SGB group (p-value<0.05). Conclusion Both US-guided SGB and blind SGB techniques were effective in relieving pain in subacute stroke patients with CRPS. US-guided SGB was better in pain relief but has no advantages in reduction of hand swelling in this study.
Henneguya adherens N. Sp. (Myxozoa, Myxosporea), Parasite of the Amazonian Fish, Acestrorhynchus falcatus

ABSTRACT. A new species of myxosporean from the gill filaments of the freshwater teleost fish, Acestrorhynchus falcatus collected in the Amazon river is described from light and transmission electron microscope observations. The mature spores (total length 32.3 [30.7–35.1] μ) and all developmental stages were found in the same sporogonic plasmodium. The ellipsoidal spore body consists of 2 unequal shell valves adhering together along the suture lines. Each valve, tapering as a caudal projection, forms a long tail (length 20.5 [18.0–21.7] μm). The tail was surrounded by a homogeneous sheath on its length. The polar capsules measuring 3.1 × 1.2 μm contain 3–4 coils of the polar filament. All surfaces of the immature and mature spores were surrounded by a closely adherent homogenous structural sheath, mainly thicker around the tails. The taxonomic affinities of this parasite to other species are discussed.
Formoterol concentrations in blood and urine: the World Anti-Doping Agency 2012 regulations.

INTRODUCTION We examined urinary and serum concentrations of formoterol in asthmatic and healthy individuals after a single dose of 18 μg inhaled formoterol and after repeated inhaled doses in healthy individuals. Results were evaluated using the World Anti-Doping Agency (WADA) 2012 threshold for formoterol. METHODS On the day of this open-label, crossover study, 10 asthmatic subjects who regularly used beta2-agonists and 10 healthy participants with no previous use of beta2-agonists received a single dose of 18 μg formoterol. Further, 10 nonasthmatic participants inhaled 18 μg formoterol every second hour until obtaining a total of 72 μg, which is twice the maximum daily dose (36 μg formoterol) permitted by the WADA. Blood samples were collected at baseline, 30 min, 1, 2, 3, 4, and 6 h after the first inhalation. Urine samples were collected at baseline, 0-4, 4-8, and 8-12 h after the first inhalation. RESULTS Median urine concentration, corrected for specific gravity, after the single-dose administration peaked during 0-4 h after inhalation at a maximum of 7.4 ng·mL(-1) in asthmatic subjects and 7.9 ng·mL(-1) in healthy subjects. Median urine concentration after repeated doses peaked during 4-8 h after inhalation of a total of 72 μg formoterol at a maximum of 16.8 ng·mL(-1) in healthy participants. The maximum individual concentration of 25.6 ng·mL(-1) was found after inhalation of a total of 72 μg formoterol. CONCLUSIONS We found no significant differences in urinary and serum concentrations of formoterol between asthmatic and healthy subjects. We found high interindividual variability in the concentrations in all groups. Our data support the WADA 2012 urinary threshold of 30 ng·mL(-1) formoterol as being an adverse analytical finding.
Clash of the Titans: MapReduce vs. Spark for Large Scale Data Analytics

MapReduce and Spark are two very popular open source cluster computing frameworks for large scale data analytics. These frameworks hide the complexity of task parallelism and fault-tolerance, by exposing a simple programming API to users. In this paper, we evaluate the major architectural components in MapReduce and Spark frameworks including: shuffle, execution model, and caching, by using a set of important analytic workloads. To conduct a detailed analysis, we developed two profiling tools: (1) We correlate the task execution plan with the resource utilization for both MapReduce and Spark, and visually present this correlation; (2) We provide a break-down of the task execution time for in-depth analysis. Through detailed experiments, we quantify the performance differences between MapReduce and Spark. Furthermore, we attribute these performance differences to different components which are architected differently in the two frameworks. We further expose the source of these performance differences by using a set of micro-benchmark experiments. Overall, our experiments show that Spark is about 2.5x, 5x, and 5x faster than MapReduce, for Word Count, k-means, and PageRank, respectively. The main causes of these speedups are the efficiency of the hash-based aggregation component for combine, as well as reduced CPU and disk overheads due to RDD caching in Spark. An exception to this is the Sort workload, for which MapReduce is 2x faster than Spark. We show that MapReduce's execution model is more efficient for shuffling data than Spark, thus making Sort run faster on MapReduce.