Miracle-dz/UniFAR-FTUs huggingface dataset:
Insecticide - treated bednet ownership and utilization in Rivers State, Nigeria before a state-wide net distribution campaign.

BACKGROUND & OBJECTIVES Malaria presents a huge health and economic burden to families living in malaria endemic areas. The use of insecticide-treated nets (ITNs) is one of the global strategies in decreasing the malaria burden on vulnerable populations. The use of ITNs reduces clinical malaria by over 50% and all cause mortality in children by 15-30% when the overall population coverage is >70%. This study was aimed at establishing the level of household insecticide -treated bednet ownership and utilization in Rivers State, Nigeria before a statewide scale -up distribution campaign. STUDY DESIGN A descriptive, cross - sectional study was carried out in the Rivers State in November 2008 among household heads or their proxies to serve as a pre -intervention baseline for the scale -up distribution of insecticide treated bednets in the state. The households were selected by a multi -staged sampling technique: first stage being the selection of Local Government Areas (LGAs) from Senatorial districts, second stage the selection of communities from LGAs and final stage the selection of households. Data were collected using a questionnaire adapted from the WHO/FMoH and analyzed using the Epi -Info version 6.04d statistical software package. Hypothesis tests were conducted to compare summary statistics at 95% significance level. RESULTS A total of 811 household heads or their proxies were interviewed. Their age ranged between 20 and 70 yr, with a mean of 47.96 ± 4.39 yr. The study showed that although 552 (68.1%) of the households owned bednets, only 245 (30.2%, 95% CI=27.1-33.5) of them owned long -lasting insecticidal nets (LLINs). Similarly, only 37.2% of those who owned ITNs slept under them the night preceding the survey. CONCLUSION Household ITN ownership and utilization were low in the state. Incorporating behavour change communication package as part of the ITN distribution intervention is advocated to increase ITNs utilization in the state.
Math talent development of elementary school students: The relationship of gender, math motivation, and goal orientation to math achievement

Research has established that motivation is an important factor of student achievement. Many researchers in the field of gifted education consider motivation to be a crucial component of giftedness, yet the literature base for motivation and math talent development within gifted populations is scarce. This descriptive study used a withingroup design to measure the math motivation, math achievement, and goal orientation of high-ability 5th grade math students to elucidate the relationships among motivation, achievement, goal orientation, and gender. Findings indicated that math achievement, math motivation, and goal orientation were similar for both genders; students had high math achievement yet low math motivation; and a high number of students had a performance goal orientation. Ideas for future math motivation research for the gifted are shared.
Management of Adult Stroke Rehabilitation Care: a clinical practice guideline.

Stroke is a leading cause of disability in the United States.1 The Veterans Health Administration (VHA) of the Department of Veterans Affairs (VA) estimates that 15 000 veterans are hospitalized for stroke each year (VA HSR&D, 1997). Forty percent of stroke patients are left with moderate functional impairments and 15% to 30% with severe disability.2 Effective rehabilitation interventions initiated early after stroke can enhance the recovery process and minimize functional disability. Improved functional outcomes for patients also contribute to patient satisfaction and reduce potential costly long-term care expenditures. There are only 45 rehabilitation bed units (RBUs) in the VA today. Many veterans who have a stroke and are admitted to a VA Medical Center will find themselves in a facility that does not offer comprehensive, integrated, multidisciplinary care. In a VA rehabilitation field survey published in December 2000, more than half of the respondents reported that the “rehabilitative care of stroke patients was incomplete, fragmented, and not well coordinated” at sites lacking a RBU (VA Stroke Medical Rehabilitation Questionnaire Results, 2000). In Department of Defense (DoD) medical treatment facilities, approximately 20 000 active-duty personnel and dependents were seen in 2002 for stroke and stroke-related diagnoses according to ICD-9 coding.3 Comprehensive treatment for stroke patients in DoD medical facilities is given primarily at medical centers. Smaller DoD community hospitals may have limited resources to see both inpatients and outpatients, relying more on the TRICARE network for ongoing stroke rehabilitation services. A growing body of evidence indicates that patients do better with a well-organized, multidisciplinary approach to post-acute rehabilitation after a stroke.4–6 The VA/DoD Stroke Rehabilitation Working Group only focused on the post–acute stroke rehabilitation care. Duncan and colleagues7 found that greater adherence to post-acute stroke rehabilitation guidelines was associated with improved patient outcomes and concluded “compliance …
Repair of exocyclic DNA adducts: rings of complexity

Exocyclic DNA adducts are mutagenic lesions that can be formed by both exogenous and endogenous mutagens/carcinogens. These adducts are structurally analogs but can differ in certain features such as ring size, conjugation, planarity and substitution. Although the information on the biological role of the repair activities for these adducts is largely unknown, considerable progress has been made on their reaction mechanisms, substrate specificities and kinetic properties that are affected by adduct structures. At least four different mechanisms appear to have evolved for the removal of specific exocyclic adducts. These include base excision repair, nucleotide excision repair, mismatch repair, and AP endonuclease‐mediated repair. This overview highlights the recent progress in such areas with emphasis on structure–activity relationships. It is also apparent that more information is needed for a better understanding of the biological and structural implications of exocyclic adducts and their repair. BioEssays 26:1195–1208, 2004. © 2004 Wiley Periodicals, Inc.
PARALLEL EVOLUTION BY CORRELATED RESPONSE: LATERAL PLATE REDUCTION IN THREESPINE STICKLEBACK

Abstract Recent work has revealed the molecular mechanisms governing one of the most dramatic examples of parallel evolution in nature: the repeated loss of lateral plate armor in freshwater populations of threespine stickleback. Yet, the ecological mechanisms responsible for armor loss remain unclear. Using a balanced experimental design, we examined Heuts' (1947) hypothesis that selection due to differences in salinity indirectly drive the reduction of lateral plate armor in fresh water while maintaining armor in the sea. We measured two fitness-related traits, hatching success and juvenile growth rate, in offspring of reduced (low and partial) and complete lateral plate morphs from two polymorphic populations when raised in either fresh water or salt water. In contrast to Heuts' results, there was little difference among morphs in hatching success. However, salinity strongly influenced juvenile growth: offspring of reduced lateral plate morphs grew substantially faster (up to 65%) than offspring of completely plated morphs in fresh water, but there was little difference in salt water. We suggest that the parallel loss of lateral plates in fresh water has arisen through a correlated response to selection for faster growth during lateral plate development, but the effect of salinity on hatching success and juvenile growth rate cannot explain the predominance of completely plated morphs in marine populations.
The Bank Capital Channel of Monetary Policy

This paper examines the role of bank lending in the transmission of monetary policy in the presence of capital adequacy regulations. I develop a dynamic model of bank asset and liability management that incorporates risk-based capital requirements and an imperfect market for bank equity. These conditions imply a failure of the Modigliani-Miller theorem for the bank: its lending will depend on the bankâ€™s financial structure, as well as on lending opportunities and market interest rates. Combined with a maturity mismatch on the bankâ€™s balance sheet, this gives rise to a â€˜bank capital channelâ€™ by which monetary policy affects bank lending through its impact on bank equity capital. This mechanism does not rely on any particular role of bank reserves and thus falls outside the conventional â€˜bank lending channelâ€™. I analyze the dynamics of the new channel. An important result is that monetary policy effects on bank lending depend on the capital adequacy of the banking sector; lending by banks with low capital has a delayed and then amplified reaction to interest rate shocks, relative to well-capitalized banks. Other implications are that bank capital affects lending even when the regulatory constraint is not momentarily binding, and that shocks to bank profits, such as loan defaults, can have a persistent impact on lending
Compact Microstrip 3-dB Coupled-Line Ring and Branch-Line Hybrids With New Symmetric Equivalent Circuits

New symmetric equivalent circuits are suggested for 90° and 270° transmission-line sections, with which compact coupled-line ring and branch-line hybrids can be designed and fabricated. For this purpose, firstly stepped-impedance transmission-line (SITL) sections, being equivalent to a uniform transmission-line section with arbitrary electrical lengths, are synthesized, and design formulas for the SITL sections are derived. Secondly, three types of equivalent circuits are introduced by combining the SITL sections with coupled-line Π-, modified Π-, or T-type, and are called stepped-impedance coupled-line Π-type (SCΠ ), stepped-impedance modified T-type (SMT), and stepped-impedance modified Π-type (SMΠ). The SCΠs are for 270° transmission-line sections, while both SMTs and SMΠs are for 90° transmission-line sections. Based on the suggested equivalent circuits, compact coupled-line ring and branch-line hybrids designed at 1 GHz are fabricated, and the measured bandwidth of the ring hybrid is 50% with 15-dB return loss. The measured results may be considered as excellent, reflecting their total transmission-line lengths of 183° and 111° for the ring and branch-line hybrids, respectively.
Bone alkaline phosphatase isoforms in hemodialysis patients with low versus non-low bone turnover: a diagnostic test study.

BACKGROUND Renal osteodystrophy encompasses the bone histologic abnormalities seen in patients with chronic kidney disease (CKD). The bone-specific alkaline phosphatase (bALP) isoform B1x is exclusively found in serum of some patients with CKD. STUDY DESIGN The aim of this cross-sectional diagnostic test study was to examine the relationship between serum bALP isoform activity and histomorphometric parameters of bone in patients with CKD receiving maintenance hemodialysis. SETTINGS & PARTICIPANTS Anterior iliac crest bone biopsy samples from 40 patients with CKD were selected on the basis of bone turnover for histomorphometric analysis. There were samples from 20 patients with low and 20 with non-low bone turnover. INDEX TEST In serum, bALP, bALP isoforms (B/I, B1x, B1, and B2), and parathyroid hormone (PTH) were measured. REFERENCE TEST Low bone turnover was defined by mineral apposition rate < 0. 36μm/d. Non-low bone turnover was defined by mineral apposition rate ≥ 0. 36μm/d. OTHER MEASUREMENTS PTH. RESULTS B1x was found in 21 patients (53%) who had lower median levels of bALP, 18.6 versus 46.9U/L; B/I, 0.10 versus 0.22 μkat/L; B1, 0.40 versus 0.88 μkat/L; B2, 1.21 versus 2.66 μkat/L; and PTH, 49 versus 287pg/mL, compared with patients without B1x (P<0.001). 13 patients (65%) with low bone turnover and 8 patients (40%) with non-low bone turnover (P<0.2) had detectable B1x. B1x correlated inversely with histomorphometric parameters of bone turnover. Receiver operating characteristic curves showed that B1x can be used for the diagnosis of low bone turnover (area under the curve [AUC], 0.83), whereas bALP (AUC, 0.89) and PTH (AUC, 0.85) are useful for the diagnosis of non-low bone turnover. LIMITATIONS Small number of study participants. Requirement of high-performance liquid chromatography methods for measurement of B1x. CONCLUSIONS B1x, PTH, and bALP have similar diagnostic accuracy in distinguishing low from non-low bone turnover. The presence of B1x is diagnostic of low bone turnover, whereas elevated bALP and PTH levels are useful for the diagnosis of non-low bone turnover.
Joint allocation of computation and communication resources in multiuser mobile cloud computing

Mobile cloud computing is offering a very powerful storage and computational facility to enhance the capabilities of resource-constrained mobile handsets. However, full exploitation of the cloud computing capabilities can be achieved only if the allocation of radio and computational capabilities is performed jointly. In this paper, we propose a method to jointly optimize the transmit power, the number of bits per symbol and the CPU cycles assigned to each application in order to minimize the power consumption at the mobile side, under an average latency constraint dictated by the application requirements. We consider the case of a set of mobile handsets served by a single cloud and we show that the optimization leads to a one-to-one relationship between the transmit power and the percentage of CPU cycles assigned to each user. Based on our optimization, we propose then a computation scheduling technique and verify the stability of the computations queue. Then we show how these queues are affected by the degrees of freedom of the channels between mobile handsets and server.
Cbl Associates with Pyk2 and Src to Regulate Src Kinase Activity, αvβ3 Integrin-Mediated Signaling, Cell Adhesion, and Osteoclast Motility

The signaling events downstream of integrins that regulate cell attachment and motility are only partially understood. Using osteoclasts and transfected 293 cells, we find that a molecular complex comprising Src, Pyk2, and Cbl functions to regulate cell adhesion and motility. The activation of integrin αvβ3 induces the [Ca2+]i-dependent phosphorylation of Pyk2 Y402, its association with Src SH2, Src activation, and the Src SH3-dependent recruitment and phosphorylation of c-Cbl. Furthermore, the PTB domain of Cbl is shown to bind to phosphorylated Tyr-416 in the activation loop of Src, the autophosphorylation site of Src, inhibiting Src kinase activity and integrin-mediated adhesion. Finally, we show that deletion of c Src or c-Cbl leads to a decrease in osteoclast migration. Thus, binding of αvβ3 integrin induces the formation of a Pyk2/Src/Cbl complex in which Cbl is a key regulator of Src kinase activity and of cell adhesion and migration. These findings may explain the osteopetrotic phenotype in the Src−/− mice.
High-Resolution Large-Eddy Simulations of Flow in a Steep Alpine Valley. Part I: Methodology, Verification, and Sensitivity Experiments

This paper investigates the steps necessary to achieve accurate simulations of flow over steep, mountainous terrain. Large-eddy simulations of flow in the Riviera Valley in the southern Swiss Alps are performed at horizontal resolutions as fine as 150 m using the Advanced Regional Prediction System. Comparisons are made with surface station and radiosonde measurements from the Mesoscale Alpine Programme (MAP)-Riviera project field campaign of 1999. Excellent agreement between simulations and observations is obtained, but only when high-resolution surface datasets are used and the nested grid configurations are carefully chosen. Simply increasing spatial resolution without incorporating improved surface data gives unsatisfactory results. The sensitivity of the results to initial soil moisture, land use data, grid resolution, topographic shading, and turbulence models is explored. Even with strong thermal forcing, the onset and magnitude of the upvalley winds are highly sensitive to surface processes in areas that are well outside the high-resolution domain. In particular, the soil moisture initialization on the 1-km grid is found to be crucial to the success of the finer-resolution predictions. High-resolution soil moisture and land use data on the 350-m-resolution grid also improve results. The use of topographic shading improves radiation curves during sunrise and sunset, but the effects on the overall flow are limited because of the strong lateral boundary forcing from the 1-km grid where terrain slopes are not well resolved. The influence of the turbulence closure is also limited because of strong lateral forcing and hence limited residence time of air inside the valley and because of the stable stratification, which limits turbulent stress to the lowest few hundred meters near the surface.
Personalization of OLAP queries

Keynote Abstract Personalizing e-services by allowing users to express preferences is becoming more and more common. When querying, expressing preferences is seen as a natural way to avoid empty results or information flooding as well as a solution reducing the user effort in carrying out complex searches. This is particularly beneficial in the OLAP context, since multidimensional databases store huge amounts of data. Besides, OLAP queries have a complex structure: they do not only formulate selections and projections on attributes and measures, they also specify on what hierarchical attributes data are to be aggregated. Finally, during an OLAP session, the user often does not exactly know what she is looking for. The reasons behind a specific phenomenon or trend may be hidden, and finding those reasons by manually applying different combinations of OLAP operators may be very frustrating.
Modeling Opportunity Costs of Conservation in Transitional Landscapes

Abstract: Conservation scientists recognize the urgency of incorporating opportunity costs into conservation planning. Despite this, applications to date have been limited, perhaps partly because of the difficulty in determining costs in regions with limited data on land prices and ownership. We present methods for estimating opportunity costs of land preservation in landscapes or ecoregions that are a changing mix of agriculture and natural habitat. Our approach derives from the literature on estimating land values as opportunity costs of alternate land uses and takes advantage of general availability of necessary data, even in relatively data‐poor regions. The methods integrate probabilities of habitat conversion with region‐wide estimates of economic benefits from agricultural land uses and estimate land values with a discount rate to convert annual values into net present values. We applied our method in a landscape undergoing agricultural conversion in Paraguay. Our model of opportunity costs predicted an independent data set of land values and was consistent with implicit discount rates of 15–25%. Model‐generated land values were strongly correlated with actual land values even after correcting for the effect of property size and proportion of property that was forested. We used the model to produce a map of opportunity costs and to estimate the costs of conserving forest within two proposed corridors in the landscape. This method can be applied to conservation planning in situations where natural habitat is currently being converted to market‐oriented land uses. Incorporating not only biological attributes but also socioeconomic data can help in the design of efficient networks of protected areas that represent biodiversity at minimum costs.
Orthopantomography contribution to prevent isquemic stroke

Objectives: The ortopantomography (OPG) can be a valuable way for an early detection of calcified atheroma plaques, thus contributing for a preliminary stroke risk evaluation. The study looks for the existence of calcified atheroma plates through the use of OPG, comparing the results with the stenosis percentage found through eco-doppler. It has been analyzed the correlation of the number of years as a smoker, arterial hypertension and body mass index, against the risk of having calcified atheroma plaques. Study Design: Observational, transversal and prospective study with 84 patients from the Dental Center of Hospital Particular de Lisboa. First the patients answered to an inquiry and them they were submitted to an OPG and an eco-doppler. Results and Conclusions: It is possible to detect calcified atheroma plaques in the carotid artery through an OPG and patients who have them have got a fifteen fold greater risk of suffering from carotid stenosis. In this study, it has been confirmed the increase in carotid stenosis for long term smokers (OR = 1,033, n=18, 42,9%). The study results show that hypertension patients have a probability 5,426 greater than normal of developing atheroma plaques (with sig=0,049). Amid analyzed patients, the correlation between obesity and the existence of carotid atheroma plaques was significant, although negative (sig=0,047). OPG can help find patients with higher risk of isquemic stroke. Key words:Orthopantomography, Stroke, Carotid disease, Calcified atheroma.
Indices of Apoptosis Activation After Blood Cardioplegia and Cardiopulmonary Bypass

Background— Cardioplegic arrest (CA) using cold blood cardioplegia (CBC) has been reported to reduce ischemia-reperfusion (IR)-induced myocardial injury via apoptosis. We studied key apoptotic mediators via the caspase-dependent and intrinsic pathways as well as poly(ADP)-ribosylating protein (PARP) activity in myocardial and peripheral tissues after CA and cardiopulmonary bypass (CBP). Methods and Results— Right atrial (RA) and skeletal muscle(SM) was harvested from cardiac surgical patients with similar baseline characteristics (N =6) before and after CPB and CBC. Total and modified caspase-3, Bcl-2, Bad, apoptosis-inducing factor (AIF), and PARP were quantified by immunoblotting. Terminal caspase-3 activity was assessed and immunohistochemistry was performed for PARP and AIF. TUNEL staining was used for identification of apoptotic cells. Microarray gene expression analysis was performed using Affymetrix U95 GeneChip. In RA tissue, CA with CBC significantly increased phosphorylation of Bcl-2 (Ser70), Bad (Ser112) (2.63±0.4 and 1.77±0.3-fold respectively; P<0.05), and cleavage of the downstream caspase 3 (1.45±0.1-fold; P<0.05). There was no significant change in total protein levels. Also, there was an increase in mature AIF (57 kDa) levels (1.22±0.01-fold; P<0.05) and a trend toward nuclear translocation on histological staining. Caspase 3 activity was increased 1.5±0.14-fold (P<0.05). The number of apoptotic cells in atrial tissue increased after compared with before CPB/CA using TUNEL staining (1.55±0.66 versus 0.325±0.05%, respectively; P=0.03). In contrast, SM samples did not show any of the changes observed in RA tissue after CPB. Conclusion— Despite optimal current surgical myocardial protection, we found that CA with CBC induced both programmed cell death and survival signaling in myocardial tissue.