Miracle-dz/UniFAR-FTUs huggingface dataset:
Online steun voor jonge mantelzorgers : wensen- en behoeften van jongeren voor een online zelfhulpprogramma

Background: The aim of this study is to investigate the wishes and needs from young carers from 12 to 21 years old with regard to interests, features, content and design to a new way of designing an online self-help program. Young carers are people between 12 and 21 years old with a mental or somatic restricted or sick parent, (little) brother or (little) sister. Nowadays there is too less attention for these people and they weren’t informed by (online) self help. Method: Respondents (N=15) were interviewed by means of a semi-structured interview schedule. Half of these youngsters are connected with SIZ Twente. The interview questions were sent to these carers. prior to the interview. By young carers beyond 18, their parents were asked for permission. They were first asked about their demographics, previous support and internet use and after that to their own wishes for an online self-help program. They were also asked to desired functionalities including information (tips, links and experience stories), participation (tests, exercises and games) and contact (professional or with peers). This is done, inter alia, on the basis of various screenshots. Possible content is discussed on the basis of theme tickets. In this way also wishes in respect of the design are mapped. Finally, they were asked about how they think the program could get attention The data is analyzed by means of inductive coding. Results: The interviewed young carers were very excited about making an online self-help program. Many of them did know of the existence of help for young carers in general. They would like to get information and tips on the program which offers them help on how they can cope with the situation in the best manner and how they can help their family the best. They are very interested in contact with peers to share their experiences with others and also to help each other. They also want to be able to get in contact with a professional. Tests and exercises seem useful to the respondents when there is clear feedback and tips are given. Discussion and conclusion: The young people are excited and curious about an online self- help program. According to the prediction, there seems too less attention to young carers. It is remarkable that they don’t only want to do it for themselves, but also to help others. They should this program, partly against expectations, would like to share with their parents. It should be a program with a base of information and innovations with tests, exercises and experience stories. It have to look nice but also serious and clear. On the findings of this research it is recommended to create an online self- help program.
A Follow-Up Study of Factors that Mediate the Development of Psychological Symptomatology in Sexually Abused Girls

This study was a follow-up investigation of several child and family factors and their impact on the development of psychological symptomatology in sexually abused girls. Sixty abused girls aged 8 to 13 were compared with 85 normal controls at 6- and 12-month follow-up assessments. The mediating variables examined included abuse-related attributions and perceptions, general attributions, locus of control, parental support, the parent's emotional reaction to the abuse, and family cohesion and adaptability. At both follow-ups, abuse-related attributions and perceptions, as measured by the Children's Attributions and Perceptions Scale, were significantly correlated with and predictive of self-reported symptoms in the abused group. Also, at the 12-month follow-up, locus of control and the parent's emotional reaction to the abuse emerged as significant predictor variables of symptom development in abused subjects. Mediating factors from the 6- to 12-month follow-up in the abused group did not change. Locus of control at the 6-month follow-up correlated significantly with trait anxiety at the 12-month follow-up. Clinical implications of these findings are discussed in the context of the evolving literature on those factors that ameliorate or exacerbate the psychological impact of child sexual abuse.
CDH13 Genotype–Dependent Association of High–Molecular Weight Adiponectin With All-Cause Mortality: The J-SHIPP Study

OBJECTIVE Despite its anti-inflammatory and antiatherogenic effects, adiponectin is potentially associated with adverse clinical outcomes, such as all-cause mortality. As plasma adiponectin levels are strongly influenced by single nucleotide polymorphisms in the gene encoding T-cadherin (CDH13), we conducted a longitudinal study to investigate the possible link between the CDH13 genotype, plasma adiponectin levels, and all-cause mortality. RESEARCH DESIGN AND METHODS This longitudinal study evaluated 2,020 Japanese subjects. Baseline clinical parameters were obtained from subjects’ personal health records as evaluated at annual medical check-ups. Plasma high–molecular weight adiponectin (HMWA) levels were measured by an ELISA assay, and genotyping was performed by a TaqMan probe assay. RESULTS Mean follow-up duration was 6.5 years. Kaplan-Meier analysis showed that HMWA levels were positively associated with mortality (P < 0.001). HMWA levels were associated with older age, lower body weight, lower plasma triglyceride and glucose levels, and higher plasma HDL cholesterol. However, the Cox regression analysis showed that the positive association between HMWA and all-cause mortality was independent of these covariates (hazard ratio [HR] 1.92, P = 0.006). The CDH13 rs4783244 genotype was strongly associated with baseline HMWA levels (per-allele effect size 1.65 μg/mL, P < 0.001). In a separate analysis by the CDH13 genotype, the HR for all-cause mortality was linearly increased with the number of G alleles (P value for HMWA–CDH13 genotype interaction = 0.023). CONCLUSIONS Higher plasma HMWA level was an independent prognostic factor for all-cause mortality in a general population. The CDH13 genotype may be a factor that affects not only the plasma level of HMWA but also the prognostic significance of HMWA.
How Accurately Do Introductory Psychology Textbooks Present Psychoanalytic Theory?

Previous studies have raised concerns about the quality of the coverage of psychoanalytic content in undergraduate psychology textbooks. The authors investigated the accuracy and currency of psychoanalytic content in top-selling introductory psychology textbooks. Across the textbooks, 2% to 18% of the paragraphs with psychoanalytic content included inaccurate or misleading statements. Consistent with previous research, this study raises concerns about the overall quality of the presentation of psychoanalytic theory to undergraduates. The authors offer suggestions both to textbook authors wishing to include the most accurate and up-to-date information and also to instructors concerned about selecting textbooks that present accurate and current psychoanalytic content.
Divergent kleisin subunits of cohesin 4 specify mechanisms to tether and 5 release meiotic chromosomes 6 7

Aaron F. Severson and Barbara J. Meyer 8 9 Howard Hughes Medical Institute and Department of Molecular and Cell Biology, 10 University of California-Berkeley, Berkeley, United States 11 12 Center for Gene Regulation in Health and Disease and Department of Biological, Geological, and 13 Environmental Sciences, Cleveland State University, Cleveland, United States 14 15 *Co-corresponding authors: 16 a.severson@csuohio.edu 17 Cleveland State University 18 BGES Department 19 2121 Euclid Avenue SI 219 20 Cleveland, OH 44115-2214 21 Phone: (216) 687-4864 22 Fax: (216) 687-6972 23 24 bjmeyer@berkeley.edu 25 Department of Molecular and Cell Biology 26 16 Barker Hall, MC 3204 27 Howard Hughes Medical Institute 28 University of California, Berkeley 29 Berkeley, CA 94720-3204 30 Phone: (510) 643-5585 31 Fax: (510) 643-5584 32 33
Energy Analysis of Hardware and Software Range Partitioning

Data partitioning is a critical operation for manipulating large datasets because it subdivides tasks into pieces that are more amenable to efficient processing. It is often the limiting factor in database performance and represents a significant fraction of the overall runtime of large data queries. This article measures the performance and energy of state-of-the-art software partitioners, and describes and evaluates a hardware range partitioner that further improves efficiency. The software implementation is broken into two phases, allowing separate analysis of the partition function computation and data shuffling costs. Although range partitioning is commonly thought to be more expensive than simpler strategies such as hash partitioning, our measurements indicate that careful data movement and optimization of the partition function can allow it to approach the throughput and energy consumption of hash or radix partitioning. For further acceleration, we describe a hardware range partitioner, or HARP, a streaming framework that offers a seamless execution environment for this and other streaming accelerators, and a detailed analysis of a 32nm physical design that matches the throughput of four to eight software threads while consuming just 6.9% of the area and 4.3% of the power of a Xeon core in the same technology generation.
A culture of camaraderie: examining emotional intelligence competencies and academic library disaster team members' attributes

This qualitative case study examines the relationship between emotional intelligence competencies and the personal attributes of academic library disaster response assistance team members who led their libraries to recover from a disaster. Using appreciative inquiry protocol to conduct individual and focus group interviews at two academic libraries—the University of Iowa, which suffered a flood in 2008 and the University of New Mexico, which underwent a fire in 2006—this research contributes to understanding disaster team members' emotional intelligence. The study presents findings from emergent thematic coding of interview transcripts, documents, and artifacts. The overarching theme was one of creating a culture of camaraderie to cope with the disaster, exemplified through teamwork, collaboration, and initiative. A more complex finding involved the realization that although solid leadership was exhibited by traditional library leaders, most often leadership was expressed through the initiative of individuals who took responsibility and made quick decisions in the moment. Other major themes were trust/trustworthiness, communications, and adaptability. The study provides another layer of understanding through the application of predetermined concept choice mapping of the data, using Goleman's (2001) Framework of Emotional Intelligence Competencies. All twenty emotional intelligence competencies were mapped in participants' transcripts. These results amplify the major themes found in the emergent thematic coding and suggest a strong relationship between emotional intelligence competencies and attributes exhibited by disaster team members as they dealt with the disasters at their respective institutions. Study findings may inform library leaders who appoint and provide training for disaster team members.
Mountain uplift explains differences in Palaeogene patterns of mammalian evolution and extinction between North America and Europe

Patterns of late Palaeogene mammalian evolution appear to be very different between Eurasia and North America. Around the Eocene–Oligocene (EO) transition global temperatures in the Northern Hemisphere plummet: following this, European mammal faunas undergo a profound extinction event (the Grande Coupure), while in North America they appear to pass through this temperature event unscathed. Here, we investigate the role of surface uplift to environmental change and mammalian evolution through the Palaeogene (66–23 Ma). Palaeogene regional surface uplift in North America caused large-scale reorganization of precipitation patterns, particularly in the continental interior, in accord with our combined stable isotope and ecometric data. Changes in mammalian faunas reflect that these were dry and high-elevation palaeoenvironments. The scenario of Middle to Late Eocene (50–37 Ma) surface uplift, together with decreasing precipitation in higher-altitude regions of western North America, explains the enigma of the apparent lack of the large-scale mammal faunal change around the EO transition that characterized western Europe. We suggest that North American mammalian faunas were already pre-adapted to cooler and drier conditions preceding the EO boundary, resulting from the effects of a protracted history of surface uplift.
Road Traffic Injuries in Kenya: The Health Burden and Risk Factors in Two Districts

Background: Road traffic injuries (RTIs) contribute to a significant proportion of the burden of disease in Kenya. They also have a significant impact on the social and economic well-being of individuals, their families, and society. However, though estimates quantifying the burden of RTIs in Kenya do exist, most of these studies date back to the early 2000s—more than one decade ago. Objective: This article aims to present the current status of road safety in Kenya. Using data from the police and vital registration systems in Kenya, we present the current epidemiology of RTIs in the nation. We also sought to assess the status of 3 well-known risk factors for RTIs—speeding and the use of helmets and reflective clothing. Methods: Data for this study were collected in 2 steps. The first step involved the collection of secondary data from the Kenya traffic police as well as the National Vital Registration System to assess the current trends of RTIs in Kenya. Following this, observational studies were conducted in the Thika and Naivasha districts in Kenya to assess the current status of speeding among all vehicles and the use of helmets and reflective clothing among motorcyclists. Results: The overall RTI rate in Kenya was 59.96 per 100,000 population in 2009, with vehicle passengers being the most affected. Notably, injuries to motorcyclists increased at an annual rate of approximately 29 percent (95% confidence interval [CI]: 27–32; P < .001). The mean age of death due to road traffic crashes was 35 years. Fatalities due to RTIs increased at an annual rate of 7 percent (95% CI: 6–8; P < .001) for the period 2004 to 2009. Observational studies revealed that 69.45 percent of vehicles in Thika and 34.32 percent of vehicles in Naivasha were speeding. Helmets were used by less than one third of motorcycle drivers in both study districts, with prevalence rates ranging between 3 and 4 percent among passengers. Conclusions: This study highlights the significant burden of RTIs in Kenya. A renewed focus on addressing this burden is necessary. Focusing on increasing helmet and reflective clothing use and enforcement of speed limits has the potential to prevent a large number of road traffic crashes, injuries, and fatalities. However, it is difficult to demonstrate the magnitude of the injury problem to policymakers with minimal or inaccurate data, and this study illustrates the need for national continuous, systematic, and sustainable data collection efforts, echoing similar calls for action throughout the injury literature.
Accumulation of Heavy Metals in Water and Some Fish Samples from Onuimo River, Imo State, Nigeria

Accumulation of some heavy metals (Cu, Zn, Cd and Cr) was determined in selected fish; Moon fish (Citharinus citharus), Tilapia fish (Oreochronus niloticus), Mud fish (Clarias anguillaris), Cat fish (Clarias gariepinus) and Carp fish (Labeo coulbie) and water samples from Onuimo River in Imo State in Nigeria. Accumulation order of heavy metals in fish samples comprised of Moon fish > Cling fish > Mud fish > Tilapia fish > Cat fish. Bioconcentration factor model used in the present study showed the following order; Moon fish = Carp fish > Cat fish > Mud fish > Tilapia fish and Moon fish = Carp fish > Tilapia >Mud fish > Cat fish for copper and zinc metals respectively. The concentration of cadmium and chromium in water samples were below detection limits of the Atomic Absorption Spectrophotometer (AAS) Machine. Concentrations of Cu, Cd, Zn and Cr were also below permissible limits of some international regulatory bodies.
Characterization of Three Kindreds With Familial Combined Hypolipidemia Caused by Loss-of-Function Mutations of ANGPTL3

Background— Angiopoietin-like protein 3 (ANGPTL3) affects lipid metabolism by inhibiting the activity of lipoprotein and endothelial lipases. Angptl3 knockout mice have marked hypolipidemia, and heterozygous carriers of ANGPLT3, loss-of-function mutations were found among individuals in the lowest quartile of plasma triglycerides in population studies. Recently, 4 related individuals with primary hypolipidemia were found to be compound heterozygotes for ANGPTL3 loss-of-function mutations. Methods and Results— We resequenced ANGPTL3 in 4 members of 3 kindreds originally identified for very low levels of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (0.97±0.16 and 0.56±0.20 mmol/L, respectively) in whom no mutations of known candidate genes for monogenic hypobetalipoproteinemia and hypoalphalipoproteinemia had been detected. These subjects were found to be homozygous or compound heterozygous for ANGPTL3 loss-of-function mutations (p.G400VfsX5, p.I19LfsX22/p.N147X) associated with the absence of ANGPTL3 in plasma. They had reduced plasma levels of triglyceride-containing lipoproteins and of HDL particles that contained only apolipoprotein A-I and pre-&bgr;–high-density lipoprotein. In addition, their apolipoprotein B–depleted sera had a reduced capacity to promote cell cholesterol efflux through the various pathways (ABCA1-, SR-BI–, and ABCG1-mediated efflux); however, these subjects had no clinical evidence of accelerated atherosclerosis. Heterozygous carriers of the ANGPTL3 mutations had low plasma ANGPTL3 and moderately reduced low-density lipoprotein cholesterol (2.52±0.38 mmol/L) but normal plasma high-density lipoprotein cholesterol. Conclusions— Complete ANGPTL3 deficiency caused by loss-of-function mutations of ANGPTL3 is associated with a recessive hypolipidemia characterized by a reduction of apolipoprotein B and apolipoprotein A-I–containing lipoproteins, changes in subclasses of high-density lipoprotein, and reduced cholesterol efflux potential of serum. Partial ANGPTL3 deficiency is associated only with a moderate reduction of low-density lipoprotein.
MUSCLE DYNAMICS DIFFERENCES BETWEEN LEGS IN HEALTHY ADULTS

Differences in muscle dynamics between the preferred and nonpreferred jumping legs of subjects in maximal, explosive exercise were examined. Eight subjects performed nonfatiguing bouts of single-legged drop jumps and rebound jumps on a force sledge apparatus. Measures of flight time, reactive strength index, peak vertical force, and vertical leg-spring stiffness were obtained for 3 drop jumps and 3 rebound jumps on both legs. Subjects utilized a stiffer leg spring and a more explosive jumping action in the nonpreferred leg when performing a cyclical rebound jumping task in comparison to a single drop jump task (observed through differences in vertical leg-spring stiffness, peak vertical force, and reactive strength index, p = 0.05). The preferred leg performed equally well in both tasks. Between-leg analysis showed no differences in dependent variables between the preferred and the nonpreferred leg in the rebound jumping protocol. However, the drop jump protocol showed significant performance differences, with flight time and reactive strength index greater in the preferred leg than the nonpreferred leg (p < 0.05). We hypothesize that, throughout the lifespan, both legs are equally trained in cyclical rebound jumping tasks through running. However, because a preferred leg must be selected when performing any one-off, single-legged jump, imbalances in this specific task develop over time with consistent selection of a preferred jumping leg. The data demonstrate that the rebound jump protocol is representative of the symmetrical mechanics of forward running and that leg-spring stiffness is modulated depending on the demands of the specific task involved. Strength and conditioning practitioners should give careful consideration to appropriate jump protocol selection and should exercise caution when comparing laboratory results to data gathered in field testing.
The distribution of ligand-binding pockets around protein-protein interfaces suggests a general mechanism for pocket formation

Protein-protein and protein-ligand interactions are ubiquitous in a biological cell. Here, we report a comprehensive study of the distribution of protein-ligand interaction sites, namely ligand-binding pockets, around protein-protein interfaces where protein-protein interactions occur. We inspected a representative set of 1,611 representative protein-protein complexes and identified pockets with a potential for binding small molecule ligands. The majority of these pockets are within a 6 Å distance from protein interfaces. Accordingly, in about half of ligand-bound protein-protein complexes, amino acids from both sides of a protein interface are involved in direct contacts with at least one ligand. Statistically, ligands are closer to a protein-protein interface than a random surface patch of the same solvent accessible surface area. Similar results are obtained in an analysis of the ligand distribution around domain-domain interfaces of 1,416 nonredundant, two-domain protein structures. Furthermore, comparable sized pockets as observed in experimental structures are present in artificially generated protein complexes, suggesting that the prominent appearance of pockets around protein interfaces is mainly a structural consequence of protein packing and thus, is an intrinsic geometric feature of protein structure. Nature may take advantage of such a structural feature by selecting and further optimizing for biological function. We propose that packing nearby protein-protein or domain-domain interfaces is a major route to the formation of ligand-binding pockets.
Developing Children in New Zealand School Physical Education

This paper critically examines the assumptions about 'childhood' and 'child development' that inform curriculum construction in school physical education. Drawing on insights from poststructuralist social theory and critical psychological perspectives, the paper argues that developmental discourses have a material life embodied in the institutional practices of school physical education. A New Zealand physical education syllabus is used as an illustrative exemplar of the ways in which developmental imperatives shape the construction of learning goals, design of curriculum experiences and teachers' observations of their students. It is argued that the construction of a normative, hierarchical trajectory for child development categorises, classifies and marginalises groups of children whose developmental patterns differ from those mapped out in the syllabus. The paper concludes by examining the conditions of possibility present in more contemporary physical education syllabi and theory that afford opportunities for thinking about physically educated children differently.