Miracle-dz/UniFAR-FTUs huggingface dataset:
Mediating role of psychiatric symptoms on the relationship between learned resourcefulness and life satisfaction among Turkish university students

Objective The transition from high school to higher education can be stressful for some students. Stressful situations can put individuals at risk of developing adverse psychological problems. The aim of the current study was to investigate the mediating role of psychiatric symptoms in the relationship between learned resourcefulness and life satisfaction of university students. Method Data were collected from 389 (285 women, 73.26%) Turkish university students from first year through senior year. To collect data, Rosenbaum's Learned Resourcefulness Scale, Satisfaction with Life Scale, and Brief Symptom Inventory were administered during a class period. A structural equation modelling (SEM) methodology was utilised to assess associations among variables. Results The SEM results indicated that the hypothesised model provided a good fit to the data. The findings revealed that learned resourcefulness as a psychological strength influenced life satisfaction both directly and indirectly via the mediating effect of psychiatric symptoms. In other words, highly resourceful university students reported low level of psychiatric symptoms, which in turn were associated with life satisfaction. Conclusions The implications of the findings were discussed in terms of cultural factors and intervention strategies for the enhancement of learned resourcefulness and life satisfaction among university students.
Performance Analysis of SSC Diversity Receivers over Correlated Ricean Fading Satellite Channels

This paper studies the performance of switch and stay combining (SSC) diversity receivers operating over correlated Ricean fading satellite channels. Using an infinite series representation for the bivariate Ricean probability density function (PDF), the PDF of the SSC output signal-to-noise ratio (SNR) is derived. Capitalizing on this PDF, analytical expressions for the corresponding cumulative distribution function (CDF), the moments of the output SNR, the moments generating function (MGF), and the average channel capacity (CC) are derived. Furthermore, by considering several families of modulated signals, analytical expressions for the average symbol error probability (ASEP) for the diversity receivers under consideration are obtained. The theoretical analysis is accompanied by representative performance evaluation results, including average output SNR (ASNR), amount of fading (AoF), outage probability, average bit error probability (ABEP), and average CC, which have been obtained by numerical techniques. The validity of some of these performance evaluation results has been verified by comparing them with previously known results obtained for uncorrelated Ricean fading channels.
Güncel Çalışmalar Işığında Örgüt İklimi

Is dunyasi yogun ve surekli degisen bir rekabet ortamina sahiptir. Isletmelerin nihai hedefi bu ortamda basarili olabilmek ve varliklarini devam ettirebilmektir. Bunun icin artik gecmiste oldugu gibi klasik bir yonetim anlayisi yeterli olmamakta, isletmelerde insan gucu ve beseri sermayenin onemi giderek daha fazla fark edilmeye baslanmaktadir. Isletmelerin deger yaratabilmesi ve surdurebilir basari elde edebilmesi rakiplerin taklit edemeyecegi oz yeteneklere sahip olmasina baglidir. Isletmelerin kendi degerlerinin farkina varabilmelerini saglayan en onemli faktorlerden biri de olumlu bir orgutsel iklimin varligidir. Ilimli bir orgut ikliminin var olmasi isletmenin nihai hedeflerine ulasacak surecte onemli bir role sahiptir. Bu baglamda, bu calismanin amaci, orgut iklimi kavrami ve iliskili diger kavramlari ele alarak, orgut iklimi boyutlarini ortaya koymak ve orgut ikliminin isletme acisindan onemini analiz etmektir. Bu amacla, literatur taramasi yapilarak, yazili ikincil verilerden yararlanilmistir
Somatotopic Organization of Perioral Musculature Innervation within the Pig Facial Motor Nucleus

The orbicularis oris and buccinator muscles of mammals form an important subset of the facial musculature, the perioral muscles. In many taxa, these muscles form a robust muscular hydrostat capable of highly manipulative fine motor movements, likely accompanied by a specialized pattern of innervation. We conducted a retrograde nerve-tracing study of cranial nerve (CN) VII in pigs (Sus scrofa) to: (1) map the motor neuron pool distributions of the superior and inferior orbicularis oris, and the buccinator, to test the hypothesis that perioral muscle motor neuron pools exhibit a somatotopic organization within the facial motor nucleus; and (2) test the hypothesis that portions of the superior orbicularis oris (SOO) motor neuron pool also exhibit a somatotopic organization, reflecting a potential compartmentalization of function of the rostral, middle, and caudal segments of this muscle. Cresyl violet histological staining showed that the pig facial motor nucleus was comprised of 7 well-defined subnuclei. Neuroanatomical tracers injected into these perioral muscles transported to the motor neuron pools of the lateral 4 of the 7 subnuclei of the facial motor nucleus. The motor neuron pools of the perioral muscles were generally segregated from motoneurons innervating other facial muscles of the rostrum. However, motor neuron pools were not confined to single nuclei but instead spanned across 3–4 subnuclei. Perioral muscle motor neuron pools overlapped but were organized somatotopically. Motor neuron pools of portions of the SOO overlapped greatly with each other but exhibited a crude somatotopy within the SOO motor neuron pool. The large and somatotopically organized SOO motor neuron pool in pigs suggests that the upper lip might be more richly innervated than the other perioral muscles and functionally divided.
Visual saliency based perceptual video coding in HEVC

Perceptual video coding has the potential to provide the same visual quality at a lower bit-rate, compared with the traditional objective quality based scheme. Visual saliency represents the probability of human attention over frames, and it is used for allocating coding bits or controlling visual quality. In this paper, a HEVC compliant perceptual video coding scheme is proposed based on visual saliency. At first visual saliency map is attained to indicate the distribution of saliency. Then refined distortion allocating method is performed in CU level with adaptive QP which is adjusted by the average visual saliency. Besides, a fast CU mode decision algorithm suitable for perceptual video coding in HEVC is proposed to accelerate the encoder. In the fast algorithm, the average saliency is used to estimate texture complexity and movements in videos. Experimental results show that up to 22.52% bit-rate and 43.48% encoding time can be saved by our methods with negligible perceptual quality loss.
Use of decision analysis in planning a management strategy for the stage N0 neck.

OBJECTIVE There are three major strategies in the treatment of patients with a stage N0 neck with squamous cell cancer of the head and neck: elective neck dissection, elective neck irradiation, and observation. Each has appropriate salvage strategies in the event of local recurrence. We used decision analysis to determine the optimal strategy for neck treatment as a function of the probability of occult cervical metastasis. DATA SOURCES We used the bibliographies of current articles and books to access clinical studies of patients with stage N0 neck cancer. STUDY SELECTION Studies that included large numbers of patients and contained a minimum 2-year follow-up, with results analyzed in terms of outcome as a function of stage of neck disease, were included. DATA EXTRACTION Specific data points were extracted from the studies independently by multiple observers, and mean values were used in the decision analysis. DATA SYNTHESIS A decision tree was constructed with use of a computer model to compare the three management strategies. Probabilities of each of the possible events depicted in the trees were inserted into the tree structure. These probabilities were gleaned from the literature as described above. A sensitivity analysis was performed to determine the optimal threshold for treatment of the neck. CONCLUSION A patient with primary squamous cell carcinoma of the head and neck and stage N0 neck status should be observed if the probability of occult cervical metastasis is less than 20%. If the probability is greater than 20%, treatment of the neck is warranted. The treatment plan should ideally involve a single modality of therapy; both neck dissection and radiation therapy are quite efficacious in the clinical context, and the decision of which one to employ should be driven by the treatment of the primary lesion. Decision analysis is useful in complex clinical situations.
Astrophysics on the Chaotic Rotation of Planetary Satellites: the Lyapunov Spectra and the Maximum Lyapunov Exponents

The possibility of dynamic chaos in the spin motion of minor natural planetary satellites is studied numerically and analytically. A satellite is modelled as a tri-axial rigid body in a fixed elliptic orbit. The Lyapunov characteristic exponents (LCEs) are used as indicators of the degree of chaos of the motion. For a set of real satellites (i.e. satellites with actual values of inertial and orbital parameters), the full Lyapunov spectra of the chaotic rotation are computed by the HQR-method of von Bremen et al. (1997). A more traditional " shadow trajectory " method for the computation of maximum LCEs is also used. Numerical LCEs obtained in the spatial and planar cases of chaotic rotation are compared to analytical estimates obtained by the separatrix map theory in the model of nonlinear resonance (here: synchronous spin-orbit resonance) as a perturbed nonlinear pendulum (Shevchenko 2000a, 2002). Further evidence is given that the agreement of the numerical data with the separatrix map theory in the planar case is very good. It is shown that the theory developed for the planar case is most probably still applicable in the case of spatial rotation, if the dynamical asymmetry of the satellite is sufficiently small or/and the orbital eccentricity is relatively large (but, for the dynamical model to be valid, not too large). The theoretical implications are discussed, and simple statistical dependences of the components of the LCE spectrum on the parameters of the problem are derived.
Are children born after infertility treatment at increased risk of retinoblastoma?

BACKGROUND Retinoblastoma (RB) is the most frequent eye tumour in children, with an incidence of 1 in 15-20,000 births. It accounts for 11% of all cancers in the first year of life. Except for the hereditary forms, its causes are not well-known. Studies have recently suggested an increased risk of RB among children born after IVF, but the relevant literature is sparse. We assessed the association between infertility treatment, subfertility and RB. METHODS We included all children living in France diagnosed with RB between 1 January 2000 and 31 December 2006 at the Institut Curie, the national reference centre for RB diagnosis and treatment. We used multiple logistic regression to compare them with a national sample of births in France in 1998 and 2003 (n = 28 170). RESULTS The study included 244 non-familial RB cases. The risk of RB increased with maternal age [adjusted odds ratio (adj OR) = 2.07, 95% confidence interval (CI) 1.33-3.22 at 35-39 years compared with younger than 25 years and adj OR = 2.42, 95% CI 1.22-4.81 at 40 years or older], but the associations with IVF (adj OR = 1.37, 95% CI 0.64-2.95) and ovarian stimulation or intrauterine insemination (adj OR = 1.35, 95% CI 0.77-2.38) were not statistically significant after adjustment for maternal age and tobacco use. Among women who had no infertility treatment, the risk of RB was significantly increased when time to pregnancy exceeded 24 months (adj OR = 2.02, 95% CI 1.17-3.48) compared with time to pregnancy ≤ 24 months. CONCLUSIONS Our study did not observe a significantly increased risk of RB associated with infertility treatment, in particular with IVF. But we did find an increased risk for women for whom time to pregnancy exceeded 24 months.
Investigating charge trapping behaviour of nanocomposite isotactic and syndiotactic polypropylene matrix

This paper presents the results of electrical characterisation of nanostructured polypropylene. In particular, space charge and charging/discharging current measurements performed on nanostructured syndiotactic and isotactic polypropylene were carried out. The nanofiller considered is a synthetic fluorohectorite which was rendered organophilic through treatment by octadecylamine. The comparison with unfilled syndiotactic and isotactic polypropylene shows that well oriented and exfoliated nanofiller can modify significantly trapping properties, as revealed by space charge and conduction current measurements. An overall improvement of electrical insulation behaviour under DC field is seen through reduced space charge accumulation with poling field. This seems to open interesting perspectives for the application of the investigated materials as improved insulation of electrical apparatus under DC stress.
Keratinocyte Growth Factor Down-regulates Expression of the Sucrase-Isomaltase Gene in Caco-2 Intestinal Epithelial Cells*

The molecular mechanisms that regulate the proliferation and differentiation of intestinal mucosal epithelial cells are not well understood. Keratinocyte growth factor (KGF) is an epithelial cell-specific growth factor that may be involved in the maintenance of mucosal epithelial populations and in mediating epithelial repair after injury. The sucrase-isomaltase (SI) gene, which encodes an enterocyte brush border disaccharidase, has served as a model for study of intestinal-specific gene expression and differentiation. KGF down-regulated SI mRNA and protein expression in Caco-2 intestinal epithelial cells but not the expression of other brush border enzymes. The down-regulation was dose- and time-dependent and specifically blocked by anti-KGF antibodies. Transfection experiments using SI promoter constructs demonstrated that KGF decreased SI gene transcription. In contrast, the stability of SI mRNA was not affected by incubation of Caco-2 cells with KGF. Electrophoretic mobility shift analysis demonstrated that binding of nuclear proteins to the SI footprint (SIF) 3 and SIF4 regulatory elements within the SI promoter region was increased in Caco-2 cells that had been incubated with KGF. In transfection experiments using a construct in which tandem copies of the SIF4-binding site were inserted upstream of the SV40 promoter and luciferase gene, incubation with KGF resulted in a significant decrease in luciferase activity. However, transfection with a similar construct containing tandem copies of SIF3 had no significant effect on SV40 promoter activity following KGF treatment. SIF4 may bind E4BP4, a previously identified transcriptional repressor protein. This factor may in part mediate the decrease in SI transcription by KGF in Caco-2 cells.
The Transition of the Motivation of the Students in the Art Faculty to Learn Programming

In this research, we have analyzed the transition of the motivation of the students in the art design faculty to learn programming using the questionnaire based on the ARCS motivation model. As a result, we have found that the change of the motivation of the students had been more prevalent in the first half of the course than the second half of the course.
Crystal Structure of Microbial Transglutaminase fromStreptoverticillium mobaraense *

The crystal structure of a microbial transglutaminase from Streptoverticillium mobaraense has been determined at 2.4 Å resolution. The protein folds into a plate-like shape, and has one deep cleft at the edge of the molecule. Its overall structure is completely different from that of the factor XIII-like transglutaminase, which possesses a cysteine protease-like catalytic triad. The catalytic residue, Cys64, exists at the bottom of the cleft. Asp255 resides at the position nearest to Cys64 and is also adjacent to His274. Interestingly, Cys64, Asp255, and His274 superimpose well on the catalytic triad “Cys-His-Asp” of the factor XIII-like transglutaminase, in this order. The secondary structure frameworks around these residues are also similar to each other. These results imply that both transglutaminases are related by convergent evolution; however, the microbial transglutaminase has developed a novel catalytic mechanism specialized for the cross-linking reaction. The structure accounts well for the catalytic mechanism, in which Asp255is considered to be enzymatically essential, as well as for the causes of the higher reaction rate, the broader substrate specificity, and the lower deamidation activity of this enzyme.
Per Aspirin ad Astra…

Taking the 110th anniversary of marketing of aspirin as starting point, the almost scary toxicological profile of aspirin is contrasted with its actual use experience. The author concludes that we are lucky that, in 1899, there was no regulatory toxicology. Adding, for the purpose of this article, a fourth R to the Three Rs, i.e. Realism, three reality-checks are carried out. The first one comes to the conclusion that the tools of toxicology are hardly adequate for the challenges ahead. The second one concludes that, specifically, the implementation of the EU REACH system is not feasible with these tools, mainly with regard to throughput. The third one challenges the belief that classical alternative methods, i.e. replacing animal test-based tools one by one, is actually leading to a new toxicology — it appears to change only patches of the patchwork, but not to overcome any inherent limitations other than ethical ones. The perspective lies in the Toxicology for the 21st Century initiatives, which aim to create a new approach from the scratch, by an evidence-based toxicology and a global “Human Toxicology Programme”.
Critical Role for Transcription Coactivator Peroxisome Proliferator-activated Receptor (PPAR)-binding Protein/TRAP220 in Liver Regeneration and PPARα Ligand-induced Liver Tumor Development*

Disruption of the gene encoding for the transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP/TRAP220/DRIP205/Med1) in the mouse results in embryonic lethality. Here, we have reported that targeted disruption of the Pbp/Pparbp gene in hepatocytes (PbpΔLiv) impairs liver regeneration with low survival after partial hepatectomy. Analysis of cell cycle progression suggests a defective exit from quiescence, reduced BrdUrd incorporation, and diminished entry into G2/M phase in PbpΔLiv hepatocytes after partial hepatectomy. PbpΔLiv hepatocytes failed to respond to hepatocyte growth factor/scatter factor, implying that hepatic PBP deficiency affects c-met signaling. Pbp gene disruption also abolishes primary mitogen-induced liver cell proliferative response. Striking abrogation of CCl4-induced hepatocellular proliferation and hepatotoxicity occurred in PbpΔLiv mice pretreated with phenobarbital due to lack of expression of xenobiotic metabolizing enzymes necessary for CCl4 activation. PbpΔLiv mice, chronically exposed to Wy-14,643, a PPARα ligand, revealed a striking proliferative response and clonal expansion of a few Pbpfl/fl hepatocytes that escaped Cre-mediated gene deletion in PbpΔLiv livers, but no proliferative expansion of PBP null hepatocytes was observed. In these PbpΔLiv mice, none of the Wy-14,643-induced hepatic adenomas and hepatocellular carcinomas was derived from PBPΔLiv hepatocytes; all liver tumors developing in PbpΔLiv mice maintained non-recombinant Pbp alleles and retained PBP expression. These studies provide direct evidence in support of a critical role of PBP/TRAP220 in liver regeneration, induction of hepatotoxicity, and hepatocarcinogenesis.
Emerging Social Strengths in Young Children With Down Syndrome

Many individuals with Down syndrome show relative strengths in social functioning throughout childhood, and they may “overuse” their social skills to compensate for other weaker domains of functioning (C. Kasari & S. Freeman, 2001; J. G. Wishart, 1996). To intervene in this area, it is important to document the emergence of this social strength, and characterize those specific skills that develop with such competence. In this study, we present data from the Bayley Scales of Infant Development comparing early developmental functioning in young children with Down syndrome (n = 23) and a mental age–matched comparison group of children with idiopathic developmental delays (n = 25) at 12 and 30 months. Results suggest that early orienting and engagement behaviors in young children with Down syndrome may emerge with greater competence than other areas of development (eg, emotion regulation, motor functioning). We also discuss the implications of this study regarding early intervention planning that targets the emerging phenotype in young children with Down syndrome.
The Etiopathogenesis of Parkinson Disease and Suggestions for Future Research. Part II

We are at a critical juncture in our knowledge of the etiology and pathogenesis of Parkinson disease (PD). It is clear that PD is not a single entity simply resulting from a dopaminergic deficit; rather it is most likely caused by a combination of genetic and environmental factors. Although there is extensive new information on the etiology and pathogenesis of PD, which may advance its treatment, new syntheses of this information are needed. The second part of this two-part, state-of-the-art review by leaders in PD research critically examines the research field to identify areas for which new knowledge and ideas might be helpful for treatment purposes. Topics reviewed in Part II are genetics, animal models, and oxidative stress.
Traffic signal optimization using cyclically expanded networks

Traditionally, the coordination of multiple traffic signals and the traffic assignment problem in an urban street network are considered as two separate optimization problems. However, it is easy to see that the traffic assignment has an influence on the optimal signal coordination and, vice versa, a change in the signal coordination changes the optimal traffic assignment. In this article, we present a cyclically time‐expanded network and a corresponding mixed integer linear programming formulation for simultaneously optimizing both the coordination of traffic signals and the traffic assignment in an urban street network. Although the new cyclically time‐expanded network provides a model of both traffic and signals close to reality, it still has the advantage of a linear objective function. Using this model, we compute optimized signal coordinations and traffic assignment on real‐world street networks. To evaluate the practical relevance of the computed solutions, we conduct extensive simulation experiments using two established traffic simulation tools that reveal the advantages of our model. © 2015 Wiley Periodicals, Inc. NETWORKS, Vol. 65(3), 244–261 2015