Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypothyroidism during antithyroid drug treatment with methimazole is a favorable prognostic indicator in patients with Graves' disease.

BACKGROUND A major problem with antithyroid drug (ATD) therapy in Graves' disease is the high relapse rate. Therefore, clinicians have sought prognostic indicators of permanent remission. Suppression of serum thyrotropin (TSH) when ATD therapy is stopped carries a poor prognosis, but little is known regarding the significance of elevated serum TSH concentrations in the course of ATD therapy. The objective of this study was to determine if elevated serum TSH concentrations during methimazole (MMI) therapy is associated with a favorable long-term prognosis. METHODS We retrospectively studied patients with Graves' disease who were initially on MMI, in whom this drug was stopped because they had undetectable thyroid-stimulating antibodies (TSAbs) or were euthyroid after at least 24 months on MMI treatment. A strategy of high MMI doses plus T4 was not used in these patients. We identified 40 patients with elevated serum TSH concentration (>10 microIU/mL) during MMI therapy (H-TSH group). Eighty-five percent of the H-TSH group had negative tests for TSAb. The H-TSH group was sex- and age-matched with 37 patients who had similar selection criteria, but did not have elevated serum TSH concentration during MMI therapy (N-TSH group). The H-TSH and N-TSH groups were similar in gross thyroid size, percentage of patients with exophthalmos, serum free thyroxine, duration of MMI treatment, TSAb status, duration that their TSAb tests remained negative, and thyroid peroxidase antibody titers. The patients were followed for 24 months after stopping MMI. RESULTS In the H-TSH group, MMI-associated hypothyroidism typically occurred after 7-8 months of treatment with daily doses of 10-15 mg MMI. No patient had severe symptoms of hypothyroidism. The percentage of patients in remission at 6, 12, and 24 months after discontinuation of MMI was 90.0, 87.5, and 85.0, respectively, in the H-TSH group and 70.3, 67.6, and 54.1, respectively, in the N-TSH group (p < 0.05 for the comparison of groups at 6 and 12 months and p < 0.001 for comparison of the groups at 24 months). CONCLUSIONS In patients with Graves' disease who are treated with MMI for at least 2 years and become euthyroid, the occurrence of elevated serum TSH concentrations during MMI treatment is a favorable indicator for long-term remission and is independent of multiple other factors including TSAb status, duration of MMI treatment, and gross parameters of goiter size.
Motion-Aware Decoding of Compressed-Sensed Video

Compressed sensing is the theory and practice of sub-Nyquist sampling of sparse signals of interest. Perfect reconstruction may then be possible with much fewer than the Nyquist required number of data. In this paper, in particular, we consider a video system where acquisition is carried out in the form of direct compressive sampling (CS) with no other form of sophisticated encoding. Therefore, the burden of quality video sequence reconstruction falls solely on the receiver side. We show that effective implicit motion estimation and decoding can be carried out at the receiver or decoder side via sparsity-aware recovery. The receiver performs sliding-window interframe decoding that adaptively estimates Karhunen-Loève bases from adjacent previously reconstructed frames to enhance the sparse representation of each video frame block, such that the overall reconstruction quality is improved at any given fixed CS rate. Experimental results included in this paper illustrate the presented developments.
The Pitx2c N‐terminal domain is a critical interaction domain required for asymmetric morphogenesis

The paired‐like homeodomain transcription factor Pitx2c has an essential role in patterning the left–right axis. However, neither its transcriptional targets nor the molecular mechanisms through which it exerts its patterning function are known. Here we provide evidence that the N‐terminal domain of Pitx2c is important for this activity. Overexpression of the Pitx2c N‐terminus in ovo randomizes the direction of heart looping, the first morphological asymmetry conserved in vertebrate embryos. In addition, the Pitx2c N‐terminal domain blocks the ability of Pitx2c to synergize with Nkx2.5 to transactivate the procollagen lysyl hydroxylase (Plod‐1) promoter in transient transfection assays. A five amino acid region containing leucine‐41 is required for both of these effects. Our data suggest that the Pitx2c N‐terminal domain competes with endogenous Pitx2c for binding to a protein interaction partner that is required for the activation of genes that direct asymmetric morphogenesis along the left–right axis. Developmental Dynamics 238:2459–2470, 2009. © 2009 Wiley‐Liss, Inc.
Role of deformation twin on texture evolution in cold-rolled commercial-purity Ti

Texture evolution of a commercial-purity titanium (CP-Ti) during cold rolling was studied by means of x-ray diffraction (XRD) and electron back-scattered diffraction (EBSD). Twinning was identified to significantly contribute to deformation up to reductions of about 50%. Based on initial texture of the material investigated and twinning modes available in hexagonal close-packed (HCP) structures, the measured texture evolution can be interpreted in terms of (i) compressive twinning ({11^¯_22}〈11^¯_2^¯_3〉) within the two dominant initial texture components B ({0001}〈10^¯_10〉±40°TD) and E ({0001}〈11^¯_20〉±40°TD) and (ii) followed by tensile twinning ({10^¯_12}〈10^¯_1^¯_1〉) in the then-favorably reoriented twinned part. Reduction of grain size at high deformation inhibits further twinning and results in a stable texture evolution driven exclusively by dislocation slip. During cold rolling, the crystals of the initial texture component B first rotate to orientation M ({01^¯_10}〈2^¯_1^¯_12〉) by compressive twinning (primary), and then orientation M rotates to orientation D ({0001}〈11^¯_20〉) by tensile twinning (secondary). Meanwhile, the crystals of the initial component E first rotate to the orientation M ′ ({14^¯_53}〈6^¯_5^¯_13〉) by compressive twinning (primary), and then orientation M ′ rotates to the orientation A ({0001}〈10^¯_10〉) by tensile twinning (secondary). At higher deformation level, twinning was significantly depressed by strongly refined grain size, which resulted in the elimination of the transient texture components caused by slip. These results are useful for the prediction and control of the texture in titanium.
A Less Cloudy Future: The Role of Subtropical Subsidence in Climate Sensitivity

Sensitivity Training Equilibrium climate sensitivity—the increase in global mean surface air temperature caused by the doubling of the concentration of atmospheric CO2—is needed to predict anthropogenic climate change. For decades, models have estimated its value to be between 1.5° and 4.5°C, but with too high an uncertainty to have strong predictive value. Fasullo and Trenberth (p. 792; see the Perspective by Shell) show that the seasonal variation of tropospheric relative humidity is related to climate sensitivity and could be used to constrain models and narrow the range of equilibrium climate sensitivity estimates, thereby allowing more accurate predictions of future warming. Seasonal variations in tropospheric relative humidity may provide an observational constraint on climate sensitivity. An observable constraint on climate sensitivity, based on variations in mid-tropospheric relative humidity (RH) and their impact on clouds, is proposed. We show that the tropics and subtropics are linked by teleconnections that induce seasonal RH variations that relate strongly to albedo (via clouds), and that this covariability is mimicked in a warming climate. A present-day analog for future trends is thus identified whereby the intensity of subtropical dry zones in models associated with the boreal monsoon is strongly linked to projected cloud trends, reflected solar radiation, and model sensitivity. Many models, particularly those with low climate sensitivity, fail to adequately resolve these teleconnections and hence are identifiably biased. Improving model fidelity in matching observed variations provides a viable path forward for better predicting future climate.
Influence of anesthesia on bladder hyperactivity induced by middle cerebral artery occlusion in the rat.

The effect of anesthesia or an N-methyl-D-aspartate (NMDA) glutamatergic antagonist (MK-801) on bladder hyperactivity induced by unilateral middle cerebral artery (MCA) occlusion was examined in female rats. Before infarction, control bladder contractions were monitored in two groups of rats: 1) awake and 2) urethan anesthetized. The awake rats were then anesthetized with halothane, and MCA occlusion was performed in both groups. After recovery from halothane, bladder capacity in awake rats was significantly reduced (60.8 +/- 1.3%) 0.5-4.5 h after MCA occlusion but not changed in urethan-anesthetized rats. MK-801 (0.1 mg/kg i.v.) administered before MCA occlusion blocked the reduction in bladder capacity in awake rats 1.5-4.5 h after MCA occlusion. Bladder capacity was not changed by sham operation in either the awake or urethan-anesthetized rats. Urethan administered after recovery from halothane anesthesia increased bladder capacity in MCA-occluded awake rats but not in sham-operated awake rats. Infarct areas in halothane, urethan-anesthetized, or MK-801-treated rats were not significantly different. These results indicate that cerebral infarction induces bladder hyperactivity in awake rats and that urethan or MK-801 inhibits the development of this hyperactivity, most likely by blocking glutamatergic transmission in the brain.
Measles outbreaks affecting children in Jewish ultra-orthodox communities in Jerusalem

SUMMARY In 2003 and 2004 two measles outbreaks occurred in Jewish ultra-orthodox communities in Jerusalem. The index case of the first outbreak (March 2003) was a 2-year-old unvaccinated child from Switzerland. Within 5 months, 107 cases (mean age 8·3±7·5 years) emerged in three crowded neighbourhoods. The first cases of the second outbreak (June 2004) were in three girls aged 4–5 years in one kindergarten in another community. By November 2004, 117 cases (mean age 7·3±6·5 years) occurred. The virus genotypes were D8 and D4 respectively. Altogether, 96 households accounted for the two outbreaks, with two or more patients per family in 79% of cases. Most cases (91·5%) were unvaccinated. Immunization coverage was lower in outbreak than in non-outbreak neighbourhoods (88·3% vs. 90·3%, P=0·001). Controlling the outbreaks necessitated a culture-sensitive approach, and targeted efforts increased MMR vaccine coverage (first dose) to 95·2%. Despite high national immunization coverage (94–95%), special attention to specific sub-populations is essential.
Navigating the human hippocampus without a GPS

The award of the Nobel Prize to Professors John O'Keefe, May‐Britt Moser, and Edvard Moser brings global recognition to one of the most significant success stories in modern neuroscience. Here, we consider how their findings, along with related studies of spatial cognition in rodents, have informed our understanding of the human hippocampus. Rather than identifying a “GPS” in the brain, we emphasize that these researchers helped to establish a fundamental role for cortico‐hippocampal networks in the guidance of behavior based on a representation of the current place, time, and situation. We conclude by highlighting the major questions that remain to be addressed in future research. © 2015 Wiley Periodicals, Inc.
Treatment of BK virus-associated hemorrhagic cystitis with low-dose intravenous cidofovir in patients undergoing allogeneic hematopoietic cell transplantation

Background/Aims BK virus (BKV) has been associated with late-onset hemorrhagic cystitis (HC) in recipients of hematopoietic stem cell transplantation (HSCT). Cidofovir has been used at higher doses (3 to 5 mg/kg/wk) with probenecid prophylaxis; however, cidofovir may result in nephrotoxicity or cytopenia at high doses. Methods Allogeneic HSCT recipients with BKV-associated HC are treated with 1 mg/kg intravenous cidofovir weekly at our institution. A microbiological response was defined as at least a one log reduction in urinary BKV viral load, and a clinical response was defined as improvement in symptoms and stability or reduction in cystitis grade. Results Eight patients received a median of 4 weekly (range, 2 to 11) doses of cidofovir. HC occurred a median 69 days (range, 16 to 311) after allogeneic HSCT. A clinical response was detected in 7/8 patients (86%), and 4/5 (80%) had a measurable microbiological response. One patient died of uncontrolled graft-versus-host disease; therefore, we could not measure the clinical response to HC treatment. One microbiological non-responder had a stable BKV viral load with clinical improvement. Only three patients showed transient grade 2 serum creatinine toxicities, which resolved after completion of concomitant calcineurin inhibitor treatment. Conclusions Weekly intravenous low-dose cidofovir without probenecid appears to be a safe and effective treatment option for patients with BKV-associated HC.
Evidence of a Minimum Patch Size Threshold of Reproductive Success in an Endangered Songbird

Abstract That area-sensitive songbirds breed only in relatively large patches suggests that there may be a minimum patch size threshold in which they will breed, even when controlling for the total amount of habitat in the landscape. We searched for minimum patch size thresholds of presence, territory establishment by males, pairing success, and reproductive success for 2 migratory songbirds that differed in sensitivity to patch size: golden-cheeked warblers (Dendroica chrysoparia) and white-eyed vireos (Vireo griseus). We assessed 2 potential limiting factors: brown-headed cowbird (Molothrus ater) parasitism and arthropod biomass (food resource). We determined whether either factor was related to patch size and compared measurements of each above and below the observed thresholds. We monitored 24 golden-cheeked warbler and 47 white-eyed vireo territories in 12 patches. We found evidence of a minimum patch size threshold (between 15.0 ha and 20.1 ha) of reproductive success for golden-cheeked warblers, but not for white-eyed vireos. We found no minimum patch size thresholds for presence, territory establishment by males, or pair formation for either species. Conservation practices based on thresholds of presence, territory establishment, or pair formation might not address issues of reproduction for golden-cheeked warblers. We failed to find evidence that cowbird parasitism or arthropod biomass were limiting factors. The ability to identify patch size thresholds of reproductive success for target species could be useful in conservation and management for setting goals for retention and restoration of target species' habitat patch size.
Evaluation of long-term toxicity in patients after cisplatin-based chemotherapy for non-seminomatous testicular cancer.

BACKGROUND Because of the increasing number of long-term survivors of metastatic testicular germ-cell cancer, a general concern has been secondary morbidities, especially cardiovascular risk factors. PATIENTS AND METHODS Thirty-two patients treated with cisplatin- and doxorubicin-containing chemotherapy > or = 13 years before the time of analyses were evaluated for neuro-, oto-, pulmonary-, vascular- and gonadal toxicity including evaluation of myocardial damage and cardiovascular risk factors and analysis of microcirculation. RESULTS Thirty percent of the patients showed abnormal left ventricle function. Elevated follicle stimulating hormone (FSH) and luteinising hormone (LH) levels in 75% of patients were often associated with low testosterone levels. Elevated total cholesterol levels were found in 82% and higher triglyceride levels in 44% of patients, most of them were overweight. About 25% of the patients developed diastolic arterial hypertension after chemotherapy. Reduced hearing was confirmed in 23% of patients, especially at frequencies higher than 3000 Hz. Moreover, 53% of patients presented transient evoked otoacoustic emissions. In 38% of patients non-symptomatic neuropathy was detected, in 28% symptomatic neuropathy, and in 6% disabling polyneuropathy. In 80% of patients with neuropathic symptoms additional morphological and functional abnormalities were found by nailfold capillary videomicroscopy, compared to only 57% of the patients without neuropathic symptoms. CONCLUSIONS Patients cured by cisplatin-based chemotherapy for metastatic testicular cancer have to be cognizant of their unfavorable cardiovascular risk profile, that might be a greater risk than developing a relapse or second malignancy.
A Novel Multilevel Multioutput Bidirectional Active Buck PFC Rectifier

This paper presents a new family of buck type power factor corrector rectifiers that operates in continuous-conduction mode (CCM) and generates a multilevel voltage waveform at the input. Due to CCM operation, commonly used ac-side capacitive filter and dc-side inductive filter are removed from the proposed modified packed U-cell rectifier structure. Dual dc output terminals are provided to have a five-level voltage waveform at the input points of the rectifier where it is supplied by a grid via a line inductor. Producing different voltage levels reduces the voltage harmonics which affects the grid current harmonic contents directly. Low switching frequency of the proposed rectifier is a distinguished characteristic among other buck type rectifiers that reduces switching losses and any high switching frequency related issues, significantly. The proposed transformerless, reduced filter, and multilevel rectifier topology has been investigated experimentally to validate the good dynamic performance in generating and regulating dual 125-V dc outputs terminals as telecommunication boards feeders or industrial battery chargers under various situation including change in the loads and change in the main grid voltage amplitude.
Asynchronous Circuits

Digital VLSI circuits are usually classi ed into synchronous and asynchronous circuits Synchronous circuits are generally controlled by global synchronization signals provided by a clock Asynchronous circuits on the other hand do not use such global synchroniza tion signals Between these extremes there are various hybrids Digital circuits in today s commercial products are almost exclusively synchronous Despite this big di erence in pop ularity there are a number of reasons why asynchronous circuits are of interest
DNA Aneuploidy and Integration of Human Papillomavirus Type 16 E6/E7 Oncogenes in Intraepithelial Neoplasia and Invasive Squamous Cell Carcinoma of the Cervix Uteri

Purpose: Increasingly deregulated expression of the E6-E7 oncogenes of high-risk human papillomaviruses (HR-HPVs) has been identified as the major transforming factor in the pathogenesis of cervical dysplasia and derived cancers. The expression of these genes in epithelial stem cells first results in chromosomal instability and induces chromosomal aneuploidy. It is speculated that this subsequently favors integration of HR-HPV genomes into cellular chromosomes. This in turn leads to expression of viral cellular fusion transcripts and further enhanced expression of the E6-E7 oncoproteins. Chromosomal instability and aneuploidization thus seems to precede and favor integration of HR-HPV genomes. Experimental Design: To prove this sequential concept, we analyzed here the sequence of events of DNA aneuploidization and integration in a series of HPV-16-positive cervical dysplastic lesions and carcinomas. Eighty-five punch biopsies of HPV-16-positive cervical lesions (20 CIN1/2, 50 CIN3, and 15 CxCa) were analyzed for DNA ploidy by DNA flow cytometry and for integration of HPV E6/E7 oncogenes using the amplification of papillomavirus oncogene transcripts assay, a reverse transcription-PCR method to detect integrate-derived human papillomavirus oncogene transcripts. Results: DNA aneuploidy and viral genome integration were both associated with increasing dysplasia (P < 0.001, χ2 test for trend). In addition, DNA aneuploidy was associated with increased viral integration (P < 0.01, Fisher’s exact test). Nineteen of 20 (95%) lesions with integrated viral genomes had aneuploid cell lines; however, only 19 of 32 (59%) lesions with aneuploid cell lines had integrated viral genomes. Conclusions: These data support the hypothesis that aneuploidization precedes integration of HR-HPV genomes in the progression of cervical dysplasia. Accordingly, deregulated viral oncogene expression appears to result first in chromosomal instability and aneuploidization and is subsequently followed by integration of HR-HPV genomes in the affected cell clones.
Stratification-Based Outlier Detection over the Deep Web

For many applications, finding rare instances or outliers can be more interesting than finding common patterns. Existing work in outlier detection never considers the context of deep web. In this paper, we argue that, for many scenarios, it is more meaningful to detect outliers over deep web. In the context of deep web, users must submit queries through a query interface to retrieve corresponding data. Therefore, traditional data mining methods cannot be directly applied. The primary contribution of this paper is to develop a new data mining method for outlier detection over deep web. In our approach, the query space of a deep web data source is stratified based on a pilot sample. Neighborhood sampling and uncertainty sampling are developed in this paper with the goal of improving recall and precision based on stratification. Finally, a careful performance evaluation of our algorithm confirms that our approach can effectively detect outliers in deep web.
Disinhibition: its effects on appetite and weight regulation

Over the past 30 years, the understanding of eating behaviour has been dominated by the concept of dietary restraint. However, the development of the Three Factor Eating Questionnaire introduced two other factors, Disinhibition and Hunger, which have not received as much recognition in the literature. The objective of this review was to explore the relationship of the Disinhibition factor with weight regulation, food choice and eating disorders, and to consider its aetiology. The review indicates that Disinhibition is an important eating behaviour trait. It is associated not only with a higher body mass index and obesity, but also with mediating variables, such as less healthful food choices, which contribute to overweight/obesity and poorer health. Disinhibition is also implicated in eating disorders and contributes to eating disorder severity. It has been demonstrated that Disinhibition is predictive of poorer success at weight loss, and of weight regain after weight loss regimes and is associated with lower self‐esteem, low physical activity and poor psychological health. Disinhibition therefore emerges as an important and dynamic trait, with influences that go beyond eating behaviour and incorporate other behaviours which contribute to weight regulation and obesity. The characteristics of Disinhibition itself therefore reflect many components representative of a thrifty type of physiology. We propose that the trait of Disinhibition be more appropriately renamed as ‘opportunistic eating’ or ‘thrifty behaviour’.