Miracle-dz/UniFAR-FTUs huggingface dataset:
Implementation of a Therapy Group for Wives of Veterans with Posttraumatic Stress Disorder: Development and Preliminary Outcomes

The purpose of this study was to develop a manualized therapy group for wives or significant others of veterans with posttraumatic stress disorder and to evaluate its effectiveness in reducing wives' psychological symptoms. A second aim of the study was to determine if women's involvement in the wives group resulted in decreases in their husbands' PTSD symptoms. Women recruited for the study were administered pre-test measures during a screening session. They then participated in a 9-session manualized therapy group designed by the researcher that included psychoeducational, process, and support components. Examples of group topics included psychoeducation regarding PTSD, assertiveness and communication, intimacy, self-care, and stress management. After completing the group sessions, participants were asked to complete post-test measures. Other factors explored in this study included marital satisfaction, perceived social support, general satisfaction with the group, and demographic variables. Results indicated that wives who participated in the group treatment exhibited significant decreases in secondary stress symptoms and increases in marital satisfaction from pre-test to post-test. The majority of participants also reported high levels of satisfaction with the group process. Therefore, it appears that the group protocol presented in this study could be a useful tool in the treatment of wives of veterans with PTSD. The results of this study have potential implications regarding the clinical treatment of families of veterans with PTSD and the development of future programs within the VA system.
Pain after thalamic stroke: Right diencephalic predominance and clinical features in 180 patients

To the Editor: A recent report in Neurology1 showed a right predominance of pain following thalamic stroke. Men displayed a statistically significant right predominance; women, a mild non-significant rightward trend. The authors underscored a particular vulnerability of pain processing to right-sided thalamic lesions consistent with …
Welding and Joining of Magnesium Alloys

Welding and joining of magnesium alloys exert a profound effect on magnesium application expansion, especially in ground and air transportations where large-size, complex components are required. This applies to joints between different grades of cast and wrought magnesium alloys and to dissimilar joints with other materials, most frequently with aluminum and steel. Due to specific physical properties of magnesium, its welding requires low and well controlled power input. Moreover, very high affinity of magnesium alloys to oxygen requires shielding gases which protect the liquid weld from an environment. To magnify complexity, also solid state reaction with oxygen, which forms a thermodynamically stable natural oxide layer on magnesium surface, is an inherent deficiency of joining (Czerwinski, 2008). Both the conventional and novel welding techniques were adapted to satisfy these requirements, including arc welding, resistance spot welding, electromagnetic welding, friction stir welding, electron beam and laser welding. Since fusion welding has a tendency to generate porosities and part distortion, many alternative joining practices were implemented. These include soldering, brazing, adhesive bonding and mechanical fastening. However, also the latter techniques have disadvantages associated, for example, with stress induced by drilling holes during mechanical fastening, preheating during clinching or extensive surface preparation in adhesive bonding. Hence, experiments are in progress with completely novel ideas of magnesium joining. An application of magnesium is often in multi-material structures, requiring dissimilar joints, involving magnesium alloys as one side where on another end there are alloys with drastically different properties. How to weld dissimilar materials is one of the most difficult problems in welding. A difference in physicochemical properties of dissimilar joint components creates challenges for mechanically bolted assemblies as well. Due to its very low electronegative potential, magnesium is susceptible to galvanic corrosion thus affecting performance of mechanical joints in conductive environments. This chapter covers key aspects of magnesium welding and joining along with engineering applications, challenges and still existing limitations. For each technique, the typical joint characteristics and possible defects are outlined with particular attention paid to weld metallurgy and its relationship with weld strength, ductility and corrosion resistance. Although fundamentals for each technique are provided, the primary focus is on recent global activities.
A framework of Dynamic Difficulty Adjustment in competitive multiplayer video games

The balance between player competence and the challenge presented by a task has been acknowledged as a major factor in providing optimal experience in video games. While Dynamic Difficulty Adjustment (DDA) presents methods for adjusting difficulty in real-time during singleplayer games, little research has explored its application in competitive multiplayer games where challenge is dictated by the competence of human opponents. By conducting a formal review of 180 existing competitive multiplayer games, it was found that a large number of modern games are utilizing DDA techniques to balance challenge between human opponents. From this data, we propose a preliminary framework for classifying Multiplayer Dynamic Difficulty Adjustment (mDDA) instances.
Masked Priming of Conceptual Features Reveals Differential Brain Activation during Unconscious Access to Conceptual Action and Sound Information

Previous neuroimaging studies suggested an involvement of sensory-motor brain systems during conceptual processing in support of grounded cognition theories of conceptual memory. However, in these studies with visible stimuli, contributions of strategic imagery or semantic elaboration processes to observed sensory-motor activity cannot be entirely excluded. In the present study, we therefore investigated the electrophysiological correlates of unconscious feature-specific priming of action- and sound-related concepts within a novel feature-priming paradigm to specifically probe automatic processing of conceptual features without the contribution of possibly confounding factors such as orthographic similarity or response congruency. Participants were presented with a masked subliminal prime word and a subsequent visible target word. In the feature-priming conditions primes as well as targets belonged to the same conceptual feature dimension (action or sound, e.g., typewriter or radio) whereas in the two non-priming conditions, either the primes or the targets consisted of matched control words with low feature relevance (e.g., butterfly or candle). Event-related potential analyses revealed unconscious feature-specific priming effects at fronto-central electrodes within 100 to 180 ms after target stimulus onset that differed with regard to topography and underlying neural generators. In congruency with previous findings under visible stimulation conditions, these differential subliminal ERP feature-priming effects demonstrate an unconscious automatic access to action versus sound features of concepts. The present results therefore support grounded cognition theory suggesting that activity in sensory and motor areas during conceptual processing can also occur unconsciously and is not mandatorily accompanied by a vivid conscious experience of the conceptual content such as in imagery.
Utilizing Hydrology and Geomorphology Relationships to Estimate Streamflow Conditions on Maui and O‘Ahu, Hawai‘I

As the population on the island of Maui drastically increases, water resource demands continue to rise. In order to match water demands and to manage water resources, it is important to understand streamflow and drainage basin interactions. If relationships between a drainage basin’s hydrologic and geomorphologic characteristics can be quantified, then streamflow conditions of ungaged streams can potentially be estimated. The baseflow recession constant is an important variable to analyze for water management, yet until this study, recession constants were not calculated for the island of Maui, or Hawai‘i as a whole. Recession constants of currently gaged streams on Maui correlated to the permeability and flow conditions of the watersheds. Streams with recession constants >0.95 were generally placed in areas of the island with dike-impounded groundwater and streams with recession constants <0.95 were generally placed in areas with dike-free groundwater. Recession constants <0.90 also indicated near perennial and/or intermittent streams. Hydrologic variables such as baseflow recession constants, low-flow values, and change in storage values are generally correlated to a watershed’s geomorphologic variables such as drainage density, hypsometric integral and concavity index. Based on equations produced from the relationships between a watershed’s hydrology and geomorphology, drainage density and hypsometric integrals are potential indicators of hydrologic variables and streamflow conditions. The same analysis can be done on other islands in Hawai‘i, but the specific relationships between hydrology and geomorphology must be determined for each island. The understanding of baseflow recession constants and relationships between a watershed’s hydrology and geomorphology can contribute to water resource management. Having the potential to predict flow conditions of ungaged streams provides a tool to identify which streams are most ideal as a freshwater source without expending extra resources to unproductively gage streams and drill for water.
Computational Aerodynamic Analysis of a Micro-CT Based Bio-Realistic Fruit Fly Wing

The aerodynamic features of a bio-realistic 3D fruit fly wing in steady state (snapshot) flight conditions were analyzed numerically. The wing geometry was created from high resolution micro-computed tomography (micro-CT) of the fruit fly Drosophila virilis. Computational fluid dynamics (CFD) analyses of the wing were conducted at ultra-low Reynolds numbers ranging from 71 to 200, and at angles of attack ranging from -10° to +30°. It was found that in the 3D bio-realistc model, the corrugations of the wing created localized circulation regions in the flow field, most notably at higher angles of attack near the wing tip. Analyses of a simplified flat wing geometry showed higher lift to drag performance values for any given angle of attack at these Reynolds numbers, though very similar performance is noted at -10°. Results have indicated that the simplified flat wing can successfully be used to approximate high-level properties such as aerodynamic coefficients and overall performance trends as well as large flow-field structures. However, local pressure peaks and near-wing flow features induced by the corrugations are unable to be replicated by the simple wing. We therefore recommend that accurate 3D bio-realistic geometries be used when modelling insect wings where such information is useful.
Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed‐batch CHO cell culture

Cell metabolism can vary considerably over the course of a typical fed‐batch antibody production process. However, the intracellular pathway alterations associated with various phases of growth and antibody production have yet to be fully elucidated using industrially relevant production hosts. Therefore, we performed 13C labeling experiments and metabolic flux analysis (MFA) to characterize CHO cell metabolism during four separate phases of a fed‐batch culture designed to closely represent industrial process conditions. First, we found that peak specific growth rate was associated with high lactate production and minimal TCA cycling. Conversely, we found that lactate metabolism switched from net production to net consumption as the culture transitioned from peak growth to peak antibody production. During the peak antibody production phase, energy was primarily generated through oxidative phosphorylation, which was also associated with elevated oxidative pentose phosphate pathway (oxPPP) activity. Interestingly, as TCA cycling and antibody production reached their peaks, specific growth rate continued to diminish as the culture entered stationary phase. However, TCA cycling and oxPPP activity remained high even as viable cell density began to decline. Overall, we found that a highly oxidative state of metabolism corresponded with peak antibody production, whereas peak cell growth was characterized by a highly glycolytic metabolic state. Biotechnol. Bioeng. 2013; 110: 2013–2024. © 2013 Wiley Periodicals, Inc.
Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy.

PURPOSE Carbonic anhydrases are proteins involved in the catalytic hydration of carbon dioxide to carbonic acid. Recent studies show that carbonic anhydrase 9 (CA9) is up-regulated by hypoxia and that its immunohistochemical tissue distribution follows the distribution of the radiosensitizer pimonidazole (C. C. Wykoff et al., Cancer Res. 60: 7075-7083, 2001). Therefore, CA9 expression may show hypoxia levels of clinical importance. EXPERIMENTAL DESIGN We assessed the expression of CA9 and the microvessel density (MVD; CD31-positive) in 75 locally advanced squamous cell head and neck cancers treated with concurrent chemoradiotherapy with carboplatin. RESULTS Strong membrane/cytoplasmic CA9 expression, noted in 20/75 (26.6%) tumors, mainly occurred in tumors with very poor vascularization (expression in 63% versus 14%; P < 0.0001), was located around areas of focal necrosis, and was related to poor complete response rate (40% versus 70%; P = 0.02). These observations suggested that CA9 might be a marker of clinically important hypoxia. Combining the CA9 staining and the tumor angiogenicity (MVD), we identified three groups of patients: (a) hypoxic tumors; (b) euoxic highly angiogenic tumors; and (c) euoxic non-highly angiogenic tumors. Groups (a) and (b) had a very poor local relapse-free survival (P < 0.0001). CONCLUSIONS Stratification of patients undergoing radical radiotherapy using the CA9/MVD model may be useful for the individualization of therapeutic strategies combining antiangiogenesis and hypoxia targeting with radiotherapy.
Glucose Metabolism During the Menstrual Cycle: Glucose Tolerance During One Cycle and Under the Effect of Ovulatory Suppressants

Intravenous glucose tolerance tests were conducted in 3 groups of women on two different occasions during a menstrual cycle—on Day 14 (estrogen peak) and on Day 24 (progesterone dominance). The first group took no medication, the second group received a sequential-type contraceptive compound, and a third group was given a progestational-type oral contraceptive preparation. Only the second group showed a slightly reduced glucose tolerance in the first test (Day 14); but it was not statistically significant It was concluded that endogenous and exogenous estrogen changes during the menstrual cycle in women had no significant effect on carbohydrate metabolism.
The contribution of a pollinating seed predator to selection on Silene latifolia females

Interactions, antagonistic or mutualistic, can exert selection on plant traits. We explored the role of Hadena bicruris, a pollinating seed predator, as a selective agent on its host, the dioecious plant Silene latifolia. We exposed females from artificial‐selection lines (many, small flowers (SF) vs. few, large flowers (LF)) to this moth. Infestation did not differ significantly between lines, but the odds of attacked fruits aborting were higher in SF females. We partitioned selection between that caused by moth attack and that resulting from all other factors. In both lines, selection via moth attack for fewer, smaller flowers contrasted with selection via other factors for more flowers. In LF females, selection via the two components was strongest and selection via moth attack also favoured increased fruit abortion. This suggests that the moths act as more of a selective force on flower size and number via their predating than their pollinating role.
Somatosensory Nerve Fibers Mediated Generation of De-qi in Manual Acupuncture and Local Moxibustion-Like Stimuli-Modulated Gastric Motility in Rats

The aim of this study was to reveal the somatosensory nerve fibers mediated generation of De-qi in manual acupuncture stimuli (MAS) and local moxibustion-like stimuli (LMS). The effects of strong and slight MAS, as well as 41°C, 43°C, and 45°C LMS at ST36 and CV12 on gastric motility were observed in rats. Gastric motility was continuously measured by an intrapyloric balloon, and the average amplitude, integral, and frequency of gastric motility during LMS were compared with those of background activity. Gastric motility was facilitated by MAS and LMS at ST36 and inhibited at CV12. The modulatory effects induced by strong MA with potent De-qi (needle grasp feeling) were markedly higher than those by slight MA with mild De-qi sensation (P < 0.05). The nociceptive 43°C and 45°C LMS, rather than nonnociceptive 41°C LMS, produced significant regulatory effects on gastric motility. Based on the afferent fibers activated in the present study, these results support the hypothesis that Aδ- and C-afferent fibers were more likely to be involved in the generation of De-qi sensation.
Automatic Identification of Conceptual Metaphors With Limited Knowledge

Full natural language understanding requires identifying and analyzing the meanings of metaphors, which are ubiquitous in both text and speech. Over the last thirty years, linguistic metaphors have been shown to be based on more general conceptual metaphors, partial semantic mappings between disparate conceptual domains. Though some achievements have been made in identifying linguistic metaphors over the last decade or so, little work has been done to date on automatically identifying conceptual metaphors. This paper describes research on identifying conceptual metaphors based on corpus data. Our method uses as little background knowledge as possible, to ease transfer to new languages and to mini- mize any bias introduced by the knowledge base construction process. The method relies on general heuristics for identifying linguistic metaphors and statistical clustering (guided by Wordnet) to form conceptual metaphor candidates. Human experiments show the system effectively finds meaningful conceptual metaphors.
Effects of Zinc Deficiency on Rice Growth and Genetic Factors Contributing to Tolerance

Zinc (Zn) deficiency is the most widespread micronutrient disorder in rice (Oryza sativa), but efforts to develop cultivars with improved tolerance have been hampered by insufficient understanding of genetic factors contributing to tolerance. The objective of this paper was to examine alternative evaluation methods and to identify the most informative traits that would provide realistic information for rice breeders and to map quantitative trait loci (QTLs) associated with tolerance. Screening experiments in low-Zn nutrient solution and in a Zn-deficient field did not produce similar tolerance rankings in a set of segregating lines, which suggested that rhizosphere effects were of greater importance for lowland rice than internal Zn efficiency. The most severe symptom in the field was high plant mortality. The occurrence of leaf bronzing, usually regarded as indicative of susceptibility, did not necessarily concur with high plant mortality, which implied that both were under independent genetic control. The QTL mapping experiment conducted in the field with a population derived from a cross of IR74 (intolerant) with Jalmagna (tolerant) largely confirmed this. Four QTLs associated with plant mortality were detected, and only one of those colocalized with one of the four QTLs detected for leaf bronzing. The two most influential QTLs for plant mortality were detected on chromosomes 2 and 12. They explained 16.6% and 24.2% of the variation, and alleles of the tolerant donor parent Jalmagna reduced mortality by 16.6% and 14.8%, respectively. QTLs for plant mortality acted in a purely additive manner, whereas digenic epistatic interactions were important for leaf bronzing.
Design and development of innovative adhesive suckers inspired by the tube feet of sea urchins

In this paper, we present an adhesion mechanism that can be used for underwater climbing robots and manipulators. The proposed design is inspired from tube feet of sea urchins, which use a combination of suction by extra soft sucker pads with assist of chemical adhesive materials. An experimental analysis of the bioinspired adhesive suckers (in single and array fashion) was performed and the obtained results show a repeatable increase in generated forces by single soft suckers, as compared with commercial sucker clamps. The main advantage of this sucker is its capability of adapting to the rough surfaces and to perform attachment. The other features of the sucker are its simple design, ease of manufacturing, and the capability of miniaturization for miniature robotic applications.
Screening for autoantibodies in patients with primary fibromyalgia syndrome and a matched control group

Primary fibromyalgia syndrome (PFS) is a non‐articular rheumatic condition characterized by chronic muscular pain. We have performed screening for autoantobodies in 20 women with PFS and in 19 age‐matched healthy women. Fifty‐five percent of the PFS patients had anti‐smooth muscle antibodies and 40% had anti‐striated muscle antibodies. None of the control subjects had any muscle antibodies. There was no significant difference in frequency of the remaining autoantibodies between the groups investigated. The present study indicates autoimmune responses in PFS against antigens of the diseased tissue itself, a finding which may be secondary to the disease or have relevance to the still obscure pathogenesis of the syndrome.
Norms in Bargaining: Evidence from Government Formation in Spain

Theories of multilateral bargaining and coalition formation applied to legislatures predict that parties’ seat shares determine their bargaining power. We present findings that are difficult to reconcile with this prediction. We use data from 2,898 municipal Spanish elections in which two parties tie in the number of seats. The party with slightly more general election votes is substantially more likely to appoint the mayor (form the government). Since tied parties should, on average, have equal bargaining power, this identifies the effect of being the most voted due to a norm prescribing that “the most voted should form government. ” The effect of being most voted is comparable in size to the effect of obtaining an additional seat. This norm binds behavior even when the second and third most voted parties can form a winning coalition that prefers the most voted not to appoint the mayor. Voters punish, in future elections, second most voted parties that appoint mayors, suggesting that they enforce the norm. We document a similar second-versus-third most voted effect and provide suggestive evidence of similar norms from 28 national European parliaments. A model where elections play a dual role (aggregating information and disciplining incumbents) and different equilibria (norms) can occur is consistent with our results and yields additional predictions.