Miracle-dz/UniFAR-FTUs huggingface dataset:
Just Care: Learning From and With Graduate Students in a Doctor of Nursing Practice Program

In 2010, Fairfield University, a Jesuit Carnegie Masters Level 1 University located in the Northeast, established its first doctoral-level program: the Doctorate of Nursing Practice (DNP). In a developing program such as the DNP, some of the most pressing concerns of current rhetoric and writing in the disciplines align and interact with the education of clinical nurse leaders—questions of transfer, ethical practice, reflection, assignment design, and community engagement. Clearly, nursing scholar/practitioners and writing scholar/practitioners have much to offer and to learn from each other. In this article, we trace the initial action-research undertaken by the School of Nursing, the Writing Center, and the Center for Academic Excellence to document, reflect upon, and support the reading and writing experiences of DNP graduate students as they negotiate the new curriculum.
Submitted to Computer Speech and Language Stochastic Natural Language Generation for Spoken Dialog Systems

We describe a corpus-based approach to natural language generation (NLG). The approach has been implemented as a component of a spoken dialog system and a series of evaluations were carried out. Our system uses n-gram language models, which have been found useful in other language technology applications, in a generative mode. It is not yet clear whether the simple n-grams can adequately model human language generation in general, but we show that we can successfully apply this ubiquitous modeling technique to the task of natural language generation for spoken dialog systems. In this paper, we discuss applying corpus-based stochastic language generation at two levels: content selection and sentence planning/realization. At the content selection level, output utterances are modeled by bigrams, and the appropriate attributes are chosen using bigram statistics. In sentence planning and realization, corpus utterances are modeled by n-grams of varying length, and new utterances are generated stochastically. Through this work, we show that a simple statistical model alone can generate appropriate language for a spoken dialog system. The results describe a promising avenue for using a statistical approach in future NLG systems. A. H. Oh: Stochastic Natural Language Generation 3 Natural Language Understanding Natural Language Generation Surface Realization Semantic (Syntactic) Representation Semantic (Syntactic) Representation Surface Realization Figure 1: NLU and NLG
Cognitive Distortions, Humor Styles, and Depression

Cognitive distortions are negative biases in thinking that are theorized to represent vulnerability factors for depression and dysphoria. Despite the emphasis placed on cognitive distortions in the context of cognitive behavioural theory and practice, a paucity of research has examined the mechanisms through which they impact depressive symptomatology. Both adaptive and maladaptive styles of humor represent coping strategies that may mediate the relation between cognitive distortions and depressive symptoms. The current study examined the correlations between the frequency and impact of cognitive distortions across both social and achievement-related contexts and types of humor. Cognitive distortions were associated with reduced use of adaptive Affiliative and Self-Enhancing humor styles and increased use of maladaptive Aggressive and Self-Defeating humor. Reduced use of Self-Enhancing humor mediated the relationship between most types of cognitive distortions and depressed mood, indicating that distorted negative thinking may interfere with an individual’s ability to adopt a humorous and cheerful outlook on life (i.e., use Self-Enhancing humor) as a way of regulating emotions and coping with stress, thereby resulting in elevated depressive symptoms. Similarly, Self-Defeating humor mediated the association of the social impact of cognitive distortions with depression, such that this humor style may be used as a coping strategy for dealing with distorted thinking that ultimately backfires and results in increased dysphoria.
Group cognitive behavioural therapy and group recreational activity for adults with autism spectrum disorders: A preliminary randomized controlled trial

Although adults with autism spectrum disorder are an increasingly identified patient population, few treatment options are available. This preliminary randomized controlled open trial with a parallel design developed two group interventions for adults with autism spectrum disorders and intelligence within the normal range: cognitive behavioural therapy and recreational activity. Both interventions comprised 36 weekly 3-h sessions led by two therapists in groups of 6–8 patients. A total of 68 psychiatric patients with autism spectrum disorders participated in the study. Outcome measures were Quality of Life Inventory, Sense of Coherence Scale, Rosenberg Self-Esteem Scale and an exploratory analysis on measures of psychiatric health. Participants in both treatment conditions reported an increased quality of life at post-treatment (d = 0.39, p < 0.001), with no difference between interventions. No amelioration of psychiatric symptoms was observed. The dropout rate was lower with cognitive behavioural therapy than with recreational activity, and participants in cognitive behavioural therapy rated themselves as more generally improved, as well as more improved regarding expression of needs and understanding of difficulties. Both interventions appear to be promising treatment options for adults with autism spectrum disorder. The interventions’ similar efficacy may be due to the common elements, structure and group setting. Cognitive behavioural therapy may be additionally beneficial in terms of increasing specific skills and minimizing dropout.
Africa and the Victorians: The Official Mind of Imperialism

Eventually, you will certainly discover a other experience and feat by spending more cash. yet when? realize you give a positive response that you require to get those all needs similar to having significantly cash? Why dont you try to get something basic in the beginning? Thats something that will guide you to comprehend even more approaching the globe, experience, some places, behind history, amusement, and a lot more?
Teachers Learning with Digital Technologies: A review of research and projects

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Futurelab Teachers Learning with Digital Technologies: A review of research and projects Tony Fisher, Chris Higgins, Avril Loveless
Disorder of G2-M Checkpoint Control in Aniline-Induced Cell Proliferation in Rat Spleen

Aniline, a toxic aromatic amine, is known to cause hemopoietic toxicity both in humans and animals. Aniline exposure also leads to toxic response in spleen which is characterized by splenomegaly, hyperplasia, fibrosis and the eventual formation of tumors on chronic in vivo exposure. Previously, we have shown that aniline exposure leads to iron overload, oxidative DNA damage, and increased cell proliferation, which could eventually contribute to a tumorigenic response in the spleen. Despite our demonstration that cell proliferation was associated with deregulation of G1 phase cyclins and increased expression of G1 phase cyclin-dependent kinases (CDKs), molecular mechanisms, especially the regulation of G2 phase and contribution of epigenetic mechanisms in aniline-induced splenic cellular proliferation remain largely unclear. This study therefore, mainly focused on the regulation of G2 phase in an animal model preceding a tumorigenic response. Male Sprague-Dawley rats were given aniline (0.5 mmol/kg/day) in drinking water or drinking water only (controls) for 30 days, and expression of G2 phase cyclins, CDK1, CDK inhibitors and miRNAs were measured in the spleen. Aniline treatment resulted in significant increases in cell cycle regulatory proteins, including cyclins A, B and CDK1, particularly phosphor-CDK1, and decreases in CDK inhibitors p21 and p27, which could promote the splenocytes to go through G2/M transition. Our data also showed upregulation of tumor markers Trx-1 and Ref-1 in rats treated with aniline. More importantly, we observed lower expression of miRNAs including Let-7a, miR-15b, miR24, miR-100 and miR-125, and greater expression of CDK inhibitor regulatory miRNAs such as miR-181a, miR-221 and miR-222 in the spleens of aniline-treated animals. Our findings suggest that significant increases in the expression of cyclins, CDK1 and aberrant regulation of miRNAs could lead to an accelerated G2/M transition of the splenocytes, and potentially to a tumorigenic response on chronic aniline exposure.
Optimal Switching In Structured Treatment Interruption For Hiv Therapy

This paper proposes ‘optimal switching control during structured treatment interruption,’ which switches RTI and PI to reduce medication and establish long‐term immune response against HIV. The proposed method is compared with ‘optimized STI’ through numerical simulation. The proposed method results in a more rapid increase of CTLp, and thus total drug intake and the therapy period are reduced. HIV treatment simulation results are analyzed in terms of controllability. Due to the effect of PI, ‘optimal switching control during STI’ can achieve greater controllability more quickly than ‘optimized STI. ’
A two way view of gender bias in medicine.

J Epidemiol Commun Health 1997;51:106-109 "It isnh true, couldn't be; there must be other variables not taken into account that confound the results. " This was the remark of an incredulous psychiatrist colleague to the statement that there is reasoned evidence of inequalities in health care based on patient gender. His re action aligns with that of health professionals' and researchers' longing for simplicity in out comes and also with a contemporary style of data analysis. It is not unusual to hear state ments like his when criticisms are voiced about health services for women compared to men. This editorial comment considers how health care contributes to the health inequalities as sociated with gender, a question addressed by many since the WHO European Report in 1990.16 There are two ways in which health service delivery and research can involve gender bias firstly, by assuming that women's and men's health situations and risks are similar, when in fact they are not, and secondly, by assuming differences where there are actually similarities. Actions and research that follow either approach may influence women's health outcomes in negative ways. An increasing num ber of scientific papers on gender bias in the past five years has intensified the debate be cause results often confirm the hypothesised presence of inequity. Yet there remain some conceptual, methodological, and empirical lim itations that keep the picture hazy.
If you build it, they will not necessarily come: The need for online communication research into communities of place

Current communication research into online communities is strongly directed at peer-topeer networks and virtual communities which are dispersed and not linked to any one physical location. The popularity of these internet communities can be attributed to the way they enable the exchange of information based on interest, practice, commerce, or support needs, and how members can easily establish social relations with each other. Within a local context, the internet holds the potential to grow strong and social capital rich communities of place which foster civic engagement, trust amongst residents and acts of reciprocity. However, this does not happen automatically, and there is a lack of understanding how local communities can make the technology work for them. Thus, new research is needed to inform the design process of online communication networks to grow sustainable communities of place.
Foundations of musicology as content processing science

Summary This paper describes musicology as a science of musical content processing. It is argued that evidence-based research and computational modeling provides a methodological basis for understanding the human information processing mechanisms that transform physical information streams into musical content and meaningful musical usage in different contexts. The focus on musical universals leads to an instrumental theory with applications in interactive music systems and audio-mining.
Hydralazine Inhibits Rapid Acrolein-Induced Protein Oligomerization: Role of Aldehyde Scavenging and Adduct Trapping in Cross-Link Blocking and Cytoprotection

Hydralazine strongly suppresses the toxicity of acrolein, a reactive aldehyde that contributes to numerous health disorders. At least two mechanisms may underlie the cytoprotection, both of which involve the nucleophilic hydrazine possessed by hydralazine. Under the simplest scenario, hydralazine directly scavenges free acrolein, decreasing intracellular acrolein availability and thereby suppressing macromolecular adduction. In a second “adduct-trapping” mechanism, the drug forms hydrazones with acrolein-derived Michael adducts in cell proteins, preventing secondary reactions of adducted proteins that may trigger cell death. To identify the most important mechanism, we explored these two pathways in mouse hepatocytes poisoned with the acrolein precursor allyl alcohol. Intense concentration-dependent adduct-trapping in cell proteins accompanied the suppression of toxicity by hydralazine. However, protective concentrations of hydralazine did not alter extracellular free acrolein levels, cellular glutathione loss, or protein carbonylation, suggesting that the cytoprotection is not due to minimization of intracellular acrolein availability. To explore ways whereby adduct-trapping might confer cytoprotection, the effect of hydralazine on acrolein-induced protein cross-linking was examined. Using bovine pancreas ribonuclease A as a model protein, acrolein caused rapid time- and concentration-dependent cross-linking, with dimerized protein detectable within 45 min of commencing protein modification. Lysine adduction in monomeric protein preceded the appearance of oligomers, whereas reductive methylation of protein amine groups abolished both adduction and oligomerization. Hydralazine inhibited cross-linking if added 30 min after commencing acrolein exposure but was ineffective if added after a 90-min delay. Adduct-trapping closely accompanied the inhibition of cross-linking by hydralazine. These findings suggest that cross-link blocking may contribute to hydralazine cytoprotection.
Super Champions, Champions, and Almosts: Important Differences and Commonalities on the Rocky Road

The real-world experiences of young athletes follow a non-linear and dynamic trajectory and there is growing recognition that facing and overcoming a degree of challenge is desirable for aspiring elites and as such, should be recognized and employed. However, there are some misunderstandings of this “talent needs trauma” perspective with some research focusing excessively or incorrectly on the incidence of life and sport challenge as a feature of effective talent development. The objective of the study was to examine what factors associated with such “trauma” experiences may or may not discriminate between high, medium, and low achievers in sport, classified as super-champions, champions or almosts. A series of retrospective interviews were used with matched triads (i.e., super-champions, champions, or almosts) of performers (N = 54) from different sports. Data collection was organized in three phases. In the first phase, a graphic time line of each performer’s career was developed. The second phase explored the specific issues highlighted by each participant in a chronological sequence. The third phase was a retrospective reflection on “traumatic” motivators, coach/significant other inputs and psychological challenges experienced and skills employed. Data suggested qualitative differences between categories of performers, relating to several perceptual and experiential features of their development. No evidence was found for the necessity of major trauma as a feature of development. There was a lack of discrimination across categories of performers associated with the incidence of trauma and, more particularly, life or non-sport trauma. These findings suggest that differences between levels of adult achievement relate more to what performers bring to the challenges than what they experience. A periodized and progressive set of challenge, preceded and associated with specific skill development, would seem to offer the best pathway to success for the majority.
Quantification and variability analysis of bacterial cross-contamination rates in common food service tasks.

This study investigated bacterial transfer rates between hands and other common surfaces involved in food preparation in the kitchen. Nalidixic acid-resistant Enterobacter aerogenes B199A was used as a surrogate microorganism to follow the cross-contamination events. Samples from at least 30 different participants were collected to determine the statistical distribution of each cross-contamination rate and to quantify the natural variability associated with that rate. The transfer rates among hands, foods, and kitchen surfaces were highly variable, being as low as 0.0005% and as high as 100%. A normal distribution was used to describe the variability in the logarithm of the transfer rates. The mean +/- SD of the normal distributions were, in log percent transfer rate, chicken to hand (0.94 +/- 0.68), cutting board to lettuce (0.90 +/- 0.59), spigot to hand (0.36 +/- 0.90), hand to lettuce (-0.12 +/- 1.07), prewashed hand to postwashed hand (i.e., hand washing efficiency) (-0.20 +/- 1.42), and hand to spigot (-0.80 +/- 1.09). Quantifying the cross-contamination risk associated with various steps in the food preparation process can provide a scientific basis for risk management efforts in both home and food service kitchens.
Decorrelating the Structure and Texture Components of a Variational Decomposition Model

The observation has been made by Aujol and Gilboa that the cartoon and texture components of the decomposition of an image should not be correlated, as they are generated from independent processes. They use this observation in order to choose an optimal fidelity parameter lambda for the decomposition process. However, this determination can be quite inefficient since a wide range of parameters lambda must be searched through before an estimated optimal parameter can be found. In the present paper, we take a different approach, in which the cartoon and texture components are explicitly decorrelated by adding a decorrelation term to the energy functional of the decomposition model of Osher, Sole, and Vese (the OSV model). Decomposition results of improved quality over those from the OSV model are obtained, as quantified by a series of new decomposition quality measures, with cartoon and texture information better separated into their respective components. A new derivation of the OSV model is developed which maintains the texture subcomponents g1 and g2 so that discrimination results similar to those from other decomposition models (e.g., from the model of Vese and Osher and Improved Edge Segregation) may be obtained. This derivation is extended to the proposed model, for which discrimination results are obtained in a substantially smaller number of iterations.
A Near-Infrared Multiplicity Survey of Class I/Flat-Spectrum Systems in Six Nearby Molecular Clouds

We present new near-IR observations of 76 Class I/flat-spectrum objects in the nearby (d ≲ 320 pc) Perseus, Taurus, Chamaeleon I and II, ρ Ophiuchi, and Serpens dark clouds. These observations are part of a larger systematic infrared multiplicity survey of self-embedded objects in the nearest dark clouds. When combined with the results of our previously published near-infrared multiplicity survey, we find a restricted companion star fraction of 14/79 (18% ± 4%) of the sources surveyed to be binary or higher order multiple systems over a separation range of ∼300–2000 AU with a magnitude difference ΔK ≤ 4 and with no correction for background contamination or completeness. This is consistent with the fraction of binary/multiple systems found among older pre–main-sequence T Tauri stars in each of the Taurus, ρ Oph, and Chamaeleon star-forming regions over a similar separation range, as well as the combined companion star fraction for these regions. However, the companion star fraction for solar-type, and lower mass M dwarf, main-sequence stars in the solar neighborhood in this separation range (11% ± 3%) is approximately one-half that of our sample. Together with multiplicity statistics derived for previously published samples of Class 0 and Class I sources, our study suggests that a significant number of binary/multiple objects may remain to be discovered at smaller separations among our Class I/flat-spectrum sample and/or most of the evolution of binary/multiple systems occurs during the Class 0 phase of early stellar evolution.
The Myth of Cognitive Decline: Non-Linear Dynamics of Lifelong Learning

As adults age, their performance on many psychometric tests changes systematically, a finding that is widely taken to reveal that cognitive information-processing capacities decline across adulthood. Contrary to this, we suggest that older adults'; changing performance reflects memory search demands, which escalate as experience grows. A series of simulations show how the performance patterns observed across adulthood emerge naturally in learning models as they acquire knowledge. The simulations correctly identify greater variation in the cognitive performance of older adults, and successfully predict that older adults will show greater sensitivity to fine-grained differences in the properties of test stimuli than younger adults. Our results indicate that older adults'; performance on cognitive tests reflects the predictable consequences of learning on information-processing, and not cognitive decline. We consider the implications of this for our scientific and cultural understanding of aging.