Miracle-dz/UniFAR-FTUs huggingface dataset:
Resolving the relationships of Paleocene placental mammals

The ‘Age of Mammals’ began in the Paleocene epoch, the 10 million year interval immediately following the Cretaceous–Palaeogene mass extinction. The apparently rapid shift in mammalian ecomorphs from small, largely insectivorous forms to many small‐to‐large‐bodied, diverse taxa has driven a hypothesis that the end‐Cretaceous heralded an adaptive radiation in placental mammal evolution. However, the affinities of most Paleocene mammals have remained unresolved, despite significant advances in understanding the relationships of the extant orders, hindering efforts to reconstruct robustly the origin and early evolution of placental mammals. Here we present the largest cladistic analysis of Paleocene placentals to date, from a data matrix including 177 taxa (130 of which are Palaeogene) and 680 morphological characters. We improve the resolution of the relationships of several enigmatic Paleocene clades, including families of ‘condylarths’. Protungulatum is resolved as a stem eutherian, meaning that no crown‐placental mammal unambiguously pre‐dates the Cretaceous–Palaeogene boundary. Our results support an Atlantogenata–Boreoeutheria split at the root of crown Placentalia, the presence of phenacodontids as closest relatives of Perissodactyla, the validity of Euungulata, and the placement of Arctocyonidae close to Carnivora. Periptychidae and Pantodonta are resolved as sister taxa, Leptictida and Cimolestidae are found to be stem eutherians, and Hyopsodontidae is highly polyphyletic. The inclusion of Paleocene taxa in a placental phylogeny alters interpretations of relationships and key events in mammalian evolutionary history. Paleocene mammals are an essential source of data for understanding fully the biotic dynamics associated with the end‐Cretaceous mass extinction. The relationships presented here mark a critical first step towards accurate reconstruction of this important interval in the evolution of the modern fauna.
The Therapeutic Role of Niacin in Dyslipidemia Management

There is abundant epidemiologic evidence to support the independent, inverse relationship between low levels of high-density lipoprotein cholesterol (HDL-C) and incident cardiovascular (CV) risk, the clinical importance of which is underscored by the high prevalence of low HDL-C in populations with coronary heart disease (CHD), with or without elevated levels of low-density lipoprotein cholesterol (LDL-C). The National Cholesterol Education Program recommended that optimal treatment for high-risk patients includes both lowering LDL-C and non-HDL-C to risk stratified levels and raising HDL-C when it is <40 mg/dL, although no target level for the latter lipoprotein was suggested. Niacin is the most powerful agent currently available for raising low levels of HDL-C. It also induces significant reductions in triglycerides, lipoprotein(a), and LDL-C levels while also favorably altering LDL particle size and number. In the Coronary Drug Project, niacin treatment was associated with significant reductions in CV events and long-term mortality, similar to the reductions seen in the statin monotherapy trials. In combination trials, niacin plus a statin or bile acid sequestrant produces additive reductions in CHD morbidity and mortality and promotes regression of coronary atherosclerosis. Recently, 2 clinical outcome trials (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes [AIM-HIGH] and Second Heart Protection Study [HPS-2 THRIVE]) failed to show a reduction in CV events in patients treated to optimally low levels of LDL-C. Despite favorable effects on HDL-C and triglycerides, these studies did not demonstrate incremental clinical benefit with niacin when added to simvastatin, although notable limitations were identified in each of these trials. Thus, there is insufficient evidence from clinical trials to recommend HDL-targeted therapy for additional event reduction at the present time. However, niacin should continue to be used as an adjuvant therapy for reducing atherogenic lipoprotein burden in patients who have not reached their risk stratified LDL-C and non-HDL-C targets.
Mutualism and Competition between Plants and Decomposers: Implications for Nutrient Allocation in Ecosystems

By examining the consequences of simultaneous mutualism and competition between plants and decomposers, we show that testable predictions about nutrient allocation in ecosystems follow from the assumption that decomposers allocate for their own growth the fraction of mineralized nutrient that maximizes their population biomass, leaving the remainder available for plant uptake. Available data for a wide variety of ecosystems are nearly all consistent with the predicted quantitative relationships among nitrogen flow rates and nitrogen fractions in plants, decomposers, and nonliving organic matter. Our predictions are robust against changes in the detailed structure of the nutrient-cycle models we use for our derivations.
The WSR-88 D Rainfall Algorithm

A detailed description of the operational WSR-88D rainfall estimation algorithm is presented. This algorithm, called the Precipitation Processing System, produces radar-derived rainfall products in real time for forecasters in support of the National Weather Service’s warning and forecast missions. It transforms reflectivity factor measurements into rainfall accumulations and incorporates rain gauge data to improve the radar estimates. The products are used as guidance to issue flood watches and warnings to the public and as input into numerical hydrologic and atmospheric models. The processing steps to quality control and compute the rainfall estimates are described, and the current deficiencies and future plans for improvement are discussed.
Non-traumatic Ocular Findings in Industrial Technical Workers in Delta State, Nigeria

Purpose: To determine the pattern of non-traumatic ocular disorders in industrial technical workers in the Delta state, Nigeria. Methods: A cross-sectional study of the pattern of non-traumatic ocular disorders among industrial technical workers in 3 factories in Ughelli North local Government Area of Delta state, Nigeria was conducted between February, 2002 and May, 2002. In addition to the demographic, the workers were studied for the presence of any non-trauma related ocular findings. Visual acuity of these workers was obtained as well as ocular examination was performed by using the Snellen's chart, pen torch, ophthalmoscope, Perkins hand-held tonometer, Ishihara plates. Patients were refracted if their visual acuity was less than normal. Results: Five hundred technical workers were screened that included 200 (40%) from the construction industry, 180 (36%) from the rubber factory and 120(24%) from the oil mill. All the workers studied were males. Ocular disorders were seen in 664 (66.4%) of the eyes. The most common ocular disorders were pingueculum 215 (21.5%), presbyopia 97 (9.7%), refractive error 94 (9.4%), pterygium 86 (8.6%) and chronic conjunctivitis 45 (4.5%). None of the workers was blind from non-traumatic causes. Only 36 (7.2%) workers wore any protective eye devices at work. Conclusion: Non-traumatic ocular disorders are common in the industrialized technical workers in the Delta state of Nigeria. The use of protective eye devices is low in these workers and suggests that measures to implement ocular safety should be undertaken in these industries.
Adenoid Cystic Carcinoma of the Upper Trachea: A Rare Neoplasm

Primary malignant tracheal tumors are not common and adenoid cystic carcinoma (ACC) of trachea is rare. We report an extremely rare case of ACC of proximal trachea, which was diagnosed in a 42-year-old male who presents with 6-month history of dyspnea. Lateral skiagram of neck, computed tomography, and magnetic resonance imaging revealed a broad-based polypoidal soft tissue mass arising from posterior wall of the proximal trachea. Biopsy confirmed the diagnosis of ACC. The patient was treated by surgical resection followed by radiotherapy and is on regular follow-up. Follow-up at 18 months post-treatment showed no local recurrence or distant metastases. The literature on tracheal ACC is reviewed. Image findings are briefly discussed.
A phase III randomised trial of LV5FU2 + irinotecan versus LV5FU2 alone in adjuvant high-risk colon cancer (FNCLCC Accord02/FFCD9802).

BACKGROUND This multicenter adjuvant phase III trial evaluated the addition of irinotecan to LV5FU2 in colon cancer patients at high risk of relapse. PATIENTS AND METHODS A total of 400 patients with histologically proven primary colon cancer with postoperative N1 detected by occlusion/perforation or N2 were randomised to: A-LV5FU2 [leucovorin 200 mg/m(2), 2-h infusion, 5-fluorouracil (5-FU) 400 mg/m(2) bolus, 600 mg/m(2) 22-h continuous infusion, days 1 and 2] or B-LV5FU2 + IRI (irinotecan 180 mg/m(2) 90-min infusion day 1 + LV5FU2) fortnightly for 12 cycles. Primary end point was disease-free survival (DFS). RESULTS Median follow-up was 63 months. Significantly more T4 tumours and 15 or more positive lymph nodes were observed in arm B. 5-FU relative dose intensity (RDI) was >0.80 for 94% and 77% in arms A and B, respectively (P < 0.001). Irinotecan RDI was >0.80 for 70% patients. There were more grades 3 and 4 neutropenia in arm B (4% versus 28%, P < 0.001). The 3-year DFS was 60% [95% confidence interval (CI) 53% to 66%] and 51% (95% CI 44% to 58) in arms A and B, respectively. No difference was observed [hazard ratio (HR) = 1.12, 95% CI 0.85-1.47, P = 0.42] even when adjusted for prognostic factors (adjusted HR = 0.98, 95% CI 0.74-1.31, P = 0.92). The 5-year overall survival (OS) was 67% (95% CI 59% to 73%) and 61% (95% CI 53% to 67%) in arms A and B, respectively. CONCLUSION Adjuvant LV5FU2 + IRI compared with LV5FU2 alone in patients at high risk of relapse showed no improvement in DFS and OS.
The Effect of Two Generic Aerobic Interval Training Methods on Laboratory and Field Test Performance in Soccer Players

Abstract da Silva, JF, Nakamura, FY, Carminatti, LJ, Dittrich, N, Cetolin, T, and Guglielmo, LGA. The effect of two generic aerobic interval training methods on laboratory and field test performance in soccer players. J Strength Cond Res 29(6): 1666–1672, 2015—The purpose of this study was to compare the effects of 2 generic aerobic training models, based on peak running velocity in Carminatti's test (PVT-CAR) in U-20 elite soccer players. Seventeen soccer players (age: 17.9 ± 1.0 years; 178.6 ± 5.0 cm; 73.6 ± 6.6 kg; 11.1 ± 1.3%) from a team competing in a national junior league took part in the study. The athletes performed a series of pre- and posttraining tests (incremental test on a treadmill to determine the maximal oxygen uptake [V[Combining Dot Above]O2max], velocity at maximal oxygen uptake [vV[Combining Dot Above]O2], the lactate threshold [LT], and T-CAR). The interval training models applied were with 180° direction change (T12:12; n = 9) and without direction change (T6:6; n = 8). No significant interaction (time vs. group) was observed for the majority of variables analyzed (p > 0.05), although significant main effects in time were evident regarding peak treadmill velocity (PVTREAD) (F = 56.3, p < 0.0001), vV[Combining Dot Above]O2max (F = 35.8, p < 0.0001), LT (F = 57.7, p < 0.0001), and PVT-CAR (F = 52.9, p < 0.0001). Moreover, there was no significant change in V[Combining Dot Above]O2max between pre and posttraining period (F = 4.26, p = 0.056) in both training groups. Thus, it can be concluded that the prescribed training with and without direction change in the intensity of the PVT-CAR increases the PVTREAD, the vV[Combining Dot Above]O2max, the LT, and the PVT-CAR similarly.
Using Neural Networks for Sensor Validation

This paper presents the results of applying two different types of neural networks in two different approaches to the sensor validation problem. The first approach uses a functional approximation neural network as part of a nonlinear observer in a model-based approach to analytical redundancy. The second approach uses an auto-associative neural network to perform nonlinear principal component analysis on a set of redundant sensors to provide an estimate for a single failed sensor. The approaches are demonstrated using a nonlinear simulation of a turbofan engine. The fault detection and sensor estimation results are presented and the training of the auto-associative neural network to provide sensor estimates is discussed.
Preparation of phosphorus‐containing and nitrogen‐containing durable flame retardant polyacrylonitrile fabric via surface chemical modification

Ultraviolet‐induced photografting polymerization combined with surface modification was developed to prepare durable flame retardant polyacrylonitrile (PAN) fabric. First, acrylic acid (AA) was grafted onto PAN fabric (PAN‐g‐PAA) through ultraviolet‐induced photograft polymerization. Then, PAN‐g‐PAA was modified sequentially by acylation, ammonization, and phosphorylation to obtain acylated PAN‐g‐PAA, ammoniated Cl‐PAN‐g‐PAA, and fire retardant PAN fabric, respectively. The influence of grafting time, concentration of acrylic acid, and initiator on the grafting percentage was studied in detail. Fourier transform infrared spectrometer, X‐ray diffraction, and scanning electron microscopy confirm the successful grafting of AA. The thermal properties of the fabrics were investigated by thermogravimetric analysis and differential scanning calorimetry. Thermal analysis indicates that FR‐PAN has good thermal stability at higher temperature and the char residue is about 41 wt% at 800°C. The limiting oxygen index value of the fire retardant fabrics can achieve 28.1 vol% and is still 27.3 vol% after 20 cycles washing, showing good durability.
In vitro terahertz spectroscopy of gelatin-embedded human brain tumors: a pilot study

We have performed the in vitro terahertz (THz) spectroscopy of human brain tumors. In order to fix tissues for the THz measurements, we have applied the gelatin embedding. It allows for preserving tissues from hydration/dehydration and sustaining their THz response similar to that of the freshly-excised tissues for a long time after resection. We have assembled an experimental setup for the reflection-mode measurements of human brain tissues based on the THz pulsed spectrometer. We have used this setup to study in vitro the refractive index and the amplitude absorption coefficient of 2 samples of malignant glioma (grade IV), 1 sample of meningioma (grade I), and samples of intact tissues. We have observed significant differences between the THz responses of normal and pathological tissues of the brain. The results of this paper highlight the potential of the THz technology in the intraoperative neurodiagnosis of tumors relying on the endogenous labels of tumorous tissues.
Built-in self-test of FPGA interconnect

We introduce the first BIST approach for testing the programmable routing network in FPGAs. Our method detects opens in, and shorts among, wiring segments, and also faults affecting the programmable switches that configure the FPGA interconnect. As a result, the BIST technique provides complete testing of interconnect faults.
A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer.

BACKGROUND & AIMS Two major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more influenced by genetic factors, although the mechanism is unknown. Our previous genome-wide association study associated 3 single nucleotide polymorphisms (SNPs) with diffuse-type gastric cancer (DGC); 1 was a functional SNP (rs2294008) in prostate stem cell antigen (PSCA), but the loci of the other 2 were not investigated. METHODS We performed high-density mapping to explore a linkage disequilibrium status of the 2 SNPs at chromosome 1q22. A DGC case-control study was conducted using DNA from 606 cases and 1264 controls (all Japanese individuals) and validated using DNA from Japanese (304 cases, 1465 controls) and Korean (452 cases, 372 controls) individuals. The effects of SNPs on function were analyzed by reporter assays and analyses of splice variants. RESULTS A region of a strong linkage disequilibrium with the 2 SNPs contained mucin 1 (MUC1) and other 4 genes and SNPs significantly associated with DGC (rs2070803: P = 4.33 × 10(-13); odds ratio [OR], 1.71 by meta-analysis of the studies on the 3 panels) but not with intestinal-type gastric cancer. Functional studies demonstrated that rs4072037 (P = 1.43 × 10(-11); OR, 1.66 by meta-analysis) in MUC1 affects promoter activity and determines the major splicing variants of MUC1 in the gastric epithelium. Individuals that carry both SNPs rs2294008 in PSCA and rs4072037 in MUC1 have a high risk for developing DGC (OR, 8.38). CONCLUSIONS MUC1 is the second major DGC susceptibility gene identified. The SNPs rs2070803 and rs4072037 in MUC1 might be used to identify individuals at risk for this type of gastric cancer.
Phosphate glass fibres with therapeutic ions release capability – a review

Phosphate-based glasses (PBG) have low melting temperatures and can be obtained by melt-quenching and sol-gel methods. The most significant characteristic of PBG is their ability to dissolve completely in aqueous solution within different timeframes. This solubility can reduce the need for revision surgeries and makes PBG well-suited for soft tissue regeneration. Phosphate glass fibres (PGF) due to their geometry and volume–surface area ratio are the subject of a growing number of studies on resorbable composites. Medical applications include bone fixation devices, nerve tissue scaffolds and wound healing. PBG can be doped with various ions to enhance their biological, chemical and structural properties allowing the preparation of fibres with designed properties and with the ability to release biologically active ions upon degradation. The aim of this review is to look in detail at the influence of different dopants on PGF behaviour, both at a structural and biological level.
Fibril Fragmentation Enhances Amyloid Cytotoxicity*♦

Fibrils associated with amyloid disease are molecular assemblies of key biological importance, yet how cells respond to the presence of amyloid remains unclear. Cellular responses may not only depend on the chemical composition or molecular properties of the amyloid fibrils, but their physical attributes such as length, width, or surface area may also play important roles. Here, we report a systematic investigation of the effect of fragmentation on the structural and biological properties of amyloid fibrils. In addition to the expected relationship between fragmentation and the ability to seed, we show a striking finding that fibril length correlates with the ability to disrupt membranes and to reduce cell viability. Thus, despite otherwise unchanged molecular architecture, shorter fibrillar samples show enhanced cytotoxic potential than their longer counterparts. The results highlight the importance of fibril length in amyloid disease, with fragmentation not only providing a mechanism by which fibril load can be rapidly increased but also creating fibrillar species of different dimensions that can endow new or enhanced biological properties such as amyloid cytotoxicity.
Water Injection Benefits in a 3-Cylinder Downsized SI-Engine

With progressing electrification of automotive powertrain and the demand to meet increasingly stringent emission regulations, a combination of electric motor and downsized turbocharged Spark Ignited Engines has been recognized a viable solution. Maximum Power and reduction of tailpipe CO2 need to come from optimizing the IC Engine. However, the increased BMEP (Brake Mean Effective Pressure) and drive for higher compression ratio/thermal efficiency increases the propensity of knocking in Downsized Engines. Engine knock occurs when the unburnt charge auto-ignites before the propagation flame reaches the unburnt charge. Currently, knock is mitigated by retarding the ignition timing. Under high power demand, ignition retard is limited by the exhaust components temperature limit. This is compensated by mixture enrichment – injecting more fuel – which in turn reduces combustion temperature at the cost of increased fuel consumption and Carbon Monoxide (CO) emissions. The potential of Water injection to alleviate these problems has been identified over the last decade – following the trail of same technology used in Aircraft combustion engines. Water Injection suppresses combustion knocking by decreasing the local in-cylinder temperature. During liquid to vapor phase transformation, water requires energy – latent heat of vaporization and the injected water absorbs most of this energy from the mixture, subsequently decreasing its temperature. Addition of adequate water can result in obtaining stoichiometric Air/Fuel Ratio engine operation henceforth leading to both reduced fuel consumption and CO emissions. For this study, a 4-stroke, 1.5 liter, 3-cylinder turbocharged engine with direct fuel injection and port water injection has been operated on 91, 95 and 98 RON Gasoline fuel. An experimental investigation to the effect of water injection on knock mitigation, combustion phasing improvement, required AFR and exhaust gas temperature control has been performed. Full load curves are presented and analyzed for different fuels and different water injection strategies.
Exploring perceptions toward biometric technology in service encounters: a comparison of current users and potential adopters

Biometrics is a new technology that authenticates an individual's identity via his or her unique physical or behavioural characteristics, such as the iris, fingerprints, hand geometry, voice and signature. Although its application is becoming pervasive in the public and private sectors due to the potential benefits of the technology, its adoption by end-users is progressing slowly. This study investigates multiple aspects of the benefits and risks that consumers perceive in using biometric technology. A survey was conducted by contacting the actual customers of an American bank that has utilised fingerprint technology at its ATMs. The proposed model was tested with current users as well as potential adopters of the target technology. We found that enjoyment was the most salient perceived benefit for using fingerprint ATMs for both current users and potential adopters. Banks thus may highlight intrinsic values, such as the novelty of biometrics, to motivate the use of the technology. However, to promote potential users' adoption decisions, banks need to educate them about the security benefits of financial transactions under the technology. The result also showed that the current users were highly concerned about information privacy risk in using the fingerprint ATMs. Therefore, banks are advised to develop internal policies to protect personal biometric data from any identity theft or illegal uses to encourage continuous usage by the current users.