Miracle-dz/UniFAR-FTUs huggingface dataset:
The Linked Response: Lessons Emerging from Integration of HIV and Reproductive Health Services in Cambodia

A qualitative assessment was made of service provider and user perceptions of the quality of integrated reproductive health services established through a pilot intervention in Cambodia. The intervention aimed to promote pregnant women's HIV testing and general utilization of reproductive health facilities as well as improve the follow-up of HIV-positive women and exposed infants through strengthened referral and operational linkages amongst health facilities/services and community-based support interventions for PLHIV. The study was conducted in one operational district where the intervention was piloted and for comparative purposes in a district where integrated services had yet to be implemented. Service providers in the pilot district reported improved collaboration and coordination of services, more effective referral, and the positive impact of improved proximity of HIV testing through integrated local level facilities. Community-based support teams for PLHIV embraced their expanded role, were valued by families receiving their assistance, and were understood to have had an important role in referral, PMTCT follow-up and countering PLHIV stigmatization; findings which underscore the potential role of community support in integrated service provision. Challenges identified included stigmatization of PLHIV by health staff at district hospital level and a lack of confidence amongst non-specialized health staff when managing deliveries by HIV-positive women, partly due to fear of HIV transmission.
Stage-Specific Inhibition of MHC Class I Presentation by the Epstein-Barr Virus BNLF2a Protein during Virus Lytic Cycle

The gamma-herpesvirus Epstein-Barr virus (EBV) persists for life in infected individuals despite the presence of a strong immune response. During the lytic cycle of EBV many viral proteins are expressed, potentially allowing virally infected cells to be recognized and eliminated by CD8+ T cells. We have recently identified an immune evasion protein encoded by EBV, BNLF2a, which is expressed in early phase lytic replication and inhibits peptide- and ATP-binding functions of the transporter associated with antigen processing. Ectopic expression of BNLF2a causes decreased surface MHC class I expression and inhibits the presentation of indicator antigens to CD8+ T cells. Here we sought to examine the influence of BNLF2a when expressed naturally during EBV lytic replication. We generated a BNLF2a-deleted recombinant EBV (ΔBNLF2a) and compared the ability of ΔBNLF2a and wild-type EBV-transformed B cell lines to be recognized by CD8+ T cell clones specific for EBV-encoded immediate early, early and late lytic antigens. Epitopes derived from immediate early and early expressed proteins were better recognized when presented by ΔBNLF2a transformed cells compared to wild-type virus transformants. However, recognition of late antigens by CD8+ T cells remained equally poor when presented by both wild-type and ΔBNLF2a cell targets. Analysis of BNLF2a and target protein expression kinetics showed that although BNLF2a is expressed during early phase replication, it is expressed at a time when there is an upregulation of immediate early proteins and initiation of early protein synthesis. Interestingly, BNLF2a protein expression was found to be lost by late lytic cycle yet ΔBNLF2a-transformed cells in late stage replication downregulated surface MHC class I to a similar extent as wild-type EBV-transformed cells. These data show that BNLF2a-mediated expression is stage-specific, affecting presentation of immediate early and early proteins, and that other evasion mechanisms operate later in the lytic cycle.
Lexical Ambiguity in Sentence Processing : Evidence from Chinese

Lexical ambiguity has been the focus for the study of context effects in word recognition in the past twenty-five years (Small, Cottrell, and Tanenhaus 1988, Onifer and Swinney 1981, Simpson and Krueger 1991, Swinney 1979, Tabossi 1988). Most of this literature has been concerned with the study of Indo-European languages, in particular, English. However, the phenomenon of lexical ambiguity is pervasive in almost all languages, and it surfaces particularly strongly in Chinese. Thus, the study of lexical ambiguity in the processing of East Asian languages is important, especially given that the previous findings in this domain are claimed to be relevant to fundamental problems of language processing. In this study, we set out to
A Quantitative Study on Endogenous Formation of Comparative Advantage in South Korea

This paper incorporates search friction and human capital accumulation into an international trade framework to analyze the endogenous formation of comparative advantage induced by long-term employment relationship. The calibrated model demonstrates that the long-term employment relationship, by facilitating both human and physical capital formation, has contributed to South Korea's rapid ‘export-oriented industrialization. ’ The counterfactual experiment reports that aggregate output in 2013 would have been reduced by one quarter, if South Korea had stayed as an autarky economy. Further counterfactual experiments find that had a typical worker's job duration been about two years from 1960s to 2010s, output in 2013 would have been reduced by more than 42 percent. Also, South Korea might have exported primary products, not secondary products with even shorter job duration or less efficient learning-by-doing.
A Study on the Properties of Alosa (Alosa caspia) By-Products Protein Hydrolysates Using Commercial Enzymes

3 Abstract: In current study, protein hydrolysates were produced using microbial proteases of Alcalase, Protamex and Flavourzyme from by-products (head, skin and viscera) of Alosa (Alosa caspia), a major Clupeonella species in the Caspian Sea. The results indicated that the protein hydrolysate from Alcalase, had the highest protein content (78.91%), protein recovery (80.42%) and degree of hydrolysis (21.06%). No significant differences in lipid were observed among the enzymes (P>0.05). The results of amino acids composition showed that all hydrolysates were almost similar in amino acids composition. In addition, the protein efficiency ratio showed that all hydrolysates had high nutritional value. The chemical score results indicated that all hydrolysates could fulfill human amino acid requirements. While, in comparison with common carp requirements, the amino acids of methionine, lysine, phenyl alanine and threonine were the limiting amino acids in hydrolysates. According to the results of this study, Alcalase is the most affective enzyme. The by-products of the Alosa hydrolysate has high nutritional value, which can be used as a protein source in fish feed.
Sustainability Reporting: Who's Kidding Whom?

The conference acted as an international wake-up call about the increasingly parlous state of the global natural environment and the alarming levels of destitution of many of the peoples of the world. That is, our ways of life - especially in the western developed nationswere essentially and increasingly un-sustainable. Five years later - at Rio+5- the re-convened conference was dismayed to discover the bulk of the indicators of the state of the planet and its peoples were continuing to move in the wrong direction. In the run-up to the Rio+10 conference, which is to be held in Johannesburg in August and September of this year, there is growing dismay that the indicators are continuing to worsen - the planet's ability to sustain human and non-human continues to decline. Understanding and then attempting to turn around a system as complex as mankind's interactions with the natural environment and how we allocate access to and the benefits from the environment is daunting and, quite clearly, involves the efforts of all parts of society business and accounting included. Indeed, the international business community - and along with it the international accounting community- may indeed be the most influential and organised of the different societal groups seeking to address what sustainability might mean for future well-being and development. However, the business and accounting communities' responses and initiatives in the area have been, at best, somewhat puzzling and, despite undoubted good intentions, may be in danger of doing more harm than good. In this short article we will highlight a few of the inconsistencies and contradictions that have been observable in the business and accounting contributions to the growing debates on sustainability and suggest a few additional possibilities that we believe could enhance that contribution.
Accounting Anomalies and Information Uncertainty 1

We examine whether rational investor responses to information uncertainty explain properties of and returns to accounting-based trading anomalies. We proxy for information uncertainty with two measures of earnings quality: the standard deviation of the residuals from a Dechow and Dichev [2002] model relating accruals to cash flows, and the absolute value of performanceadjusted abnormal accruals from a modified Jones [1991] model. Over 1982-2001, we find that accounting-based trading anomalies (post-earnings announcement drift, value-glamour, and accruals strategies) are correlated with earnings quality. Specifically, extreme anomaly portfolios have poorer earnings quality than non-extreme portfolios, and within the extreme anomaly portfolios, poor earnings quality securities are more prevalent and earn larger abnormal returns than good earnings quality securities. Consistent with greater resolution of uncertainty for poor earnings quality securities, the abnormal returns to poor quality securities converge to the abnormal returns to good quality securities as the post-portfolio formation period lengthens. Taken as a whole, these results indicate that information uncertainty plays an important role in explaining accounting anomalies.
The three-dimensional structure of Kilauea Volcano, Hawaii, from travel time tomography

A linear, travel time tomography study of the most active shield volcano of the world, Kilauea Volcano, Hawaii, was undertaken to determine the lateral heterogeneities produced by its intricate magmatic and tectonic environment. Kilauea provides an ideal setting to do tomography because of its dense seismograph array and many local earthquakes that allow excellent ray coverage of complex subsurface features. Local P wave data from ∼ 12,295 events were inverted using a one-dimensional layered velocity model. Inversions were done for two cell sizes (5×5×5 km and 1×1×1 km) to resolve structural regions on different length scales. This study provided a view of the average velocity variations relative to a one-dimensional velocity model. Analysis and interpretation of the tomographic images allowed us to infer the following model. The main shallow magma reservoir is delineated by a slow velocity region southeast of the summit from 0 to 2 km depth. There is a distinct high velocity region centered northwest of the summit from 0 to 2 km depth that represents a cap of dense, intrusive dikes surrounding the magma chamber. We suggest that the shallow reservoir is a narrow, compartmentalized region of sills and dikes, centered just south-southeast of Halemaumau caldera. Below the main reservoir, the summit is imaged as a slightly fast region from 5 to 10 km in the coarse model indicating that the main conduit is structurally defined by an intrusive dike complex until about 10 km. The rift zones of Kilauea are imaged as major, high velocity entities, widening to the south with depth until 6 km. These fast anomalies are related to the sheeted dike complexes along the rifts. On a finer scale, slow anomalies suggest the presence of magma pockets centered at 0–2 km depth beneath Mauna Ulu, Makaopuhi and Puu Oo, along the east rift zone (ERZ). Two significant high velocity regions along the lower ERZ near Kalalua and Kaliu are inferred to represent intrusive barriers to magma injection along the shallow (0–4 km) ERZ conduit. The southwest rift zone may have an intrusive barrier related to a high velocity region just southwest of Mauna Iki. The Hilina and Kaoiki fault zones are imaged as slow features at shallow depths (< 5 km) related to the open fractures and scarps along the normal faults. The Koae fault system is imaged as a slightly fast shallow structure (< 6 km) possibly related to intrusive diking from the adjacent rift zones that fill and may even induce the extensional structures associated with this complex fault zone. Continued inversions with the immense amount of seismic data collected for Hawaiian events will allow the detailed development of a three-dimensional structural model for Kilauea. Such a model will be extremely useful to seismologists and petrologists alike for understanding the tectonic growth and magmatic evolution of this dynamic shield volcano.
European Conference on Information Systems ( ECIS ) 1-1-2009 Panel : IS has outgrown the need for reference discipline theories , or has it ?

In the decade since the creation of wireless handheld devices, mobile commerce (m-commerce) has become a ubiquitous channel for accessing information and conducting business. Mobile users can now access information anytime and anywhere. Mobile advertising, retailing, and gambling are popular, and gradually the competition among mobile services providers turns fierce. Hence, some services providers adopt personalization technologies to customize content for their users. This paper explores the opportunities and challenges of the use of personalization technologies in m-commerce. Although the effectiveness of personalization on the web is well-examined, there is little work on personalization in mobile services. The debates regarding the effectiveness of personalization and technological limitations and privacy concerns motivate us to conduct focus groups with mobile users, and explore the opportunities and challenges of personalized mobile services. The focus groups findings illustrate that mobile users are very concerned about their privacy and spam. We then extract a list of personal information from the focus groups findings. This list of personal information is highly related to mobile users’ privacy concerns. We conduct an online survey to gain a better understanding of which piece of information mobile users are more willing to share with services providers and we perform a multi-dimensional scale analysis.
A Tutorial on Interaction

Abstract In this tutorial, we provide a broad introduction to the topic of interaction between the effects of exposures. We discuss interaction on both additive and multiplicative scales using risks, and we discuss their relation to statistical models (e.g. linear, log-linear, and logistic models). We discuss and evaluate arguments that have been made for using additive or multiplicative scales to assess interaction. We further discuss approaches to presenting interaction analyses, different mechanistic forms of interaction, when interaction is robust to unmeasured confounding, interaction for continuous outcomes, qualitative or “crossover” interactions, methods for attributing effects to interactions, case-only estimators of interaction, and power and sample size calculations for additive and multiplicative interaction.
Cholesterol efflux from cells to immunopurified subfractions of human high density lipoprotein: LP-AI and LP-AI/AII.

Using immunoaffinity chromatography, we separated human high density lipoprotein (HDL) into two subfractions: LP-AI, in which all particles contain apolipoprotein A-I (apoA-I) but no apoA-II, and LP-AI/AII, in which all particles contain both apoA-I and apoA-II. To compare LP-AI and LP-AI/AII as acceptors of cell cholesterol, the isolated subfractions were diluted to 50 micrograms phospholipid/ml, and then incubated with monolayer cultures of cells in which whole-cell and lysosomal cholesterol has been labeled with 14C and 3H, respectively. We used three cell types (Fu5AH rat hepatoma cells, normal human skin fibroblasts, and rabbit aortic smooth muscle cells). When these cells were prepared to contain normal physiological quantities of cholesterol (20-35 micrograms/mg protein), LP-AI and LP-AI/AII were nearly equally efficient in promoting efflux of both whole-cell and lysosomal cholesterol. For whole-cell cholesterol, the rate constants for efflux to LP-AI and LP-AI/AII were: 0.050/h and 0.053/h, respectively, with Fu5AH cells; 0.0063/h and 0.0074/h with GM3468 human skin fibroblasts; and 0.0076/h and 0.0079/h with rabbit aortic smooth muscle cells. When cholesterol in hepatoma cells or fibroblasts was elevated two- to threefold above normal, there was still not difference in efflux of whole-cell cholesterol to LP-AI and LP-AI/AII. In longterm incubations, the net depletion of cholesterol mass from cholesterol-enriched cells was either identical with the two HDL subfractions, or somewhat greater with LP-AI/AII. (ABSTRACT TRUNCATED AT 250 WORDS)
Trajectory Tracking Control of Snake Robots Based on Dynamic Model

In this paper, we derive a dynamic model and a trajectory tracking control law for snake robots, which have passive wheels and active joints, based on the dynamic model. For a trajectory tracking control of snake robots, it is one of the important problem to avoid the singular configuration like a straight line. Using input-ouput linearization for the head position of snake robots based on dynamic model, we can control the head position by PD feedback, but the robot will converge to the singular configuration. In order to solve this problem, we propose a control law that controls shape controllable points for avoiding the singular configuration. Using the proposed control law, the robot can accomplish trajectory tracking of the head position without converging to the singular configuration. Simulation results show the effectiveness of the proposed control law.
A Note on the Estimation of Markup Pricing in Manufacturing

Earlier results on estimating markup ratios as indicators of the competitive pressure are discussed and it is shown that the estimation method suggested by Roeger (1995) suffers from similar problems as an earlier method suggested by Hall (1988). It is also shown that the estimating equations applied are prone to autocorrelation and heteroskedasticity and that a proper treatment of these problems implies estimates of the markup ratios or more precisely the relation between the markup and the scale factor, which are smaller than those reported in the literature.
A tunable zinc finger-based framework for Boolean logic computation in mammalian cells

The ability to perform molecular-level computation in mammalian cells has the potential to enable a new wave of sophisticated cell-based therapies and diagnostics. To this end, we developed a Boolean logic framework utilizing artificial Cys2–His2 zinc finger transcription factors (ZF-TFs) as computing elements. Artificial ZFs can be designed to specifically bind different DNA sequences and thus comprise a diverse set of components ideal for the construction of scalable networks. We generate ZF-TF activators and repressors and demonstrate a novel, general method to tune ZF-TF response by fusing ZF-TFs to leucine zipper homodimerization domains. We describe 15 transcriptional activators that display 2- to 463-fold induction and 15 transcriptional repressors that show 1.3- to 16-fold repression. Using these ZF-TFs, we compute OR, NOR, AND and NAND logic, employing hybrid promoters and split intein-mediated protein splicing to integrate signals. The split intein strategy is able to fully reconstitute the ZF-TFs, maintaining them as a uniform set of computing elements. Together, these components comprise a robust platform for building mammalian synthetic gene circuits capable of precisely modulating cellular behavior.
Oct-2 DNA binding transcription factor: functional consequences of phosphorylation and glycosylation

Phosphorylation and O-GlcNAc modification often induce conformational changes and allow the protein to specifically interact with other proteins. Interplay of phosphorylation and O-GlcNAc modification at the same conserved site may result in the protein undergoing functional switches. We describe that at conserved Ser/Thr residues of human Oct-2, alternative phosphorylation and O-GlcNAc modification (Yin Yang sites) can be predicted by the YinOYang1.2 method. We propose here that alternative phosphorylation and O-GlcNAc modification at Ser191 in the N-terminal region, Ser271 and 274 in the linker region of two POU sub-domains and Thr301 and Ser323 in the POUh subdomain are involved in the differential binding behavior of Oct-2 to the octamer DNA motif. This implies that phosphorylation or O-GlcNAc modification of the same amino acid may result in a different binding capacity of the modified protein. In the C-terminal domain, Ser371, 389 and 394 are additional Yin Yang sites that could be involved in the modulation of Oct-2 binding properties.
Ineffective parenting and childhood conduct problems: the moderating role of callous-unemotional traits.

A sample of 6- to 13-year-old clinic-referred (n = 136) and volunteer (n = 30) participants was investigated for a potential interaction between the quality of parenting that a child receives and callous-unemotional traits in the child for predicting conduct problems. Ineffective parenting was associated with conduct problems only in children without significant levels of callous (e.g. lack of empathy, manipulativeness) and unemotional (e.g., lack of guilt, emotional constrictedness) traits. In contrast, children high on these traits exhibited a significant number of conduct problems, regardless of the quality of parenting they experienced. Results are interpreted in the context of a model that proposes that callous-unemotional traits designate a group of children with conduct problems who have distinct causal factors involved in the development of their problematic behavior.
Comparing Different Optimisation Strategies for Nonlinear Mapping and Mapping Large Datasets using Neural Networks

Reducing the dimensionality of high-dimensional data allows easier visualisation of data, facilitating more efficient extraction of knowledge. Nonlinear mapping methods transform data existing in high-dimensional space into a lowerdimensional space such that the topological characteristics of the high-dimensional data are preserved. Recent work [6] [4] proposed a particle swarm optimisation algorithm to perform nonlinear mapping. Experimental results show a comparison between a number of optimisation algorithms in performing nonlinear mapping. Nonlinear mapping methods were designed to perform mapping on datasets that contain a small number of data points. To map large datasets, such as fault management systems in telecommunication networks, a different strategy is required. A proposed method that uses a Neural Network to perform nonlinear mapping on larger datasets is discussed.