Miracle-dz/UniFAR-FTUs huggingface dataset:
Please Scroll down for Article Ergonomics Sitting Comfort and Discomfort and the Relationships with Objective Measures Sitting Comfort and Discomfort and the Relationships with Objective Measures

This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, redistribution , reselling , loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. The concepts of comfort and discomfort in sitting are under debate. There is no widely accepted definition, although it is beyond dispute that comfort and discomfort are feelings or emotions that are subjective in nature. Yet, beside several subjective methodologies, several objective methods (e.g. posture analysis, pressure measurements, electromyography (EMG) are in use to assess sitting comfort or discomfort. In the current paper a theoretical framework is presented, in which comfort and discomfort were defined and the hypothetical associations with underlying factors were indicated. Next, the literature was reviewed to determine the relationships between objective measures and subjective ratings of comfort and discomfort. Twenty-one studies were found in which simultaneous measures of an objective parameter and a subjective rating of comfort or discomfort were obtained. Pressure distribution appears to be the objective measure with the most clear association with the subjective ratings. For other variables, regarding spinal profile or muscle activity for instance, the reported associations are less clear and usually not statistically significant. 1. Introduction In Western societies, the end user comfort of products has developed into an important issue, not only recognized by the end users themselves. Producers recognize comfort as a major selling point, as it is thought to play an increasingly important role in product-buying decisions. Also, employers are getting interested in comfortable equipment for their employees in order to create a healthy and stimulating working environment. End user comfort of products is also well-addressed in the ergonomics literature. One of the products often considered is the seat. Evaluative studies on sitting comfort are numerous and mainly concerned with office seats (e.g. Bendix et al. 1985, van Diee¨n et al. 2001), passenger seats in public transport (e.g. Zhoa and Tang 1994) …
Korp and Karp – A Bestiary of Language Resources: The Research Infrastructure of Språkbanken

A central activity in Sprakbanken, an R&D unit at the University of Gothenburg, is the systematic construction of a research infrastructure based on interoperability and widely accepted standards for metadata and data. The two main components of this infrastructure deal with text corpora and with lexical resources. For modularity and flexibility, both components have a backend, or server-side part, accessed through an API made up of a set of well-defined web services. This means that there can be any number of different user interfaces to these components, corresponding, e.g., to different research needs. Here, we will demonstrate the standard corpus and lexicon search interfaces, designed primarily for linguistic searches: Korp and Karp.
Silenced yeast chromatin is maintained by Sir2 in preference to permitting histone acetylations for efficient NER

Very little is currently known about how nucleotide excision repair (NER) functions at the ends of chromosomes. To examine this, we introduced the URA3 gene into either transcriptionally active or repressed subtelomeric regions of the yeast genome. This enabled us to examine the repair of ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPDs) in identical sequences under both circumstances. We found that NER is significantly more efficient in the non-repressed subtelomere than the repressed one. At the non-repressed subtelomere, UV radiation stimulates both histones H3 and H4 acetylation in a similar fashion to that seen at other regions of the yeast genome. These modifications occur regardless of the presence of the Sir2 histone deacetylase. On the other hand, at the repressed subtelomere, where repair is much less efficient, UV radiation is unable to stimulate histone H4 or H3 acetylation in the presence of Sir2. In the absence of Sir2 both of these UV-induced modifications are detected, resulting in a significant increase in NER efficiency in the region. Our experiments reveal that there are instances in the yeast genome where the maintenance of the existing chromatin structures dominates over the action of chromatin modifications associated with efficient NER.
Cosmic‐ray exposure histories of the lunar meteorites AaU 012 and Shişr 166

We measured the concentrations and isotopic compositions of the stable isotopes of He, Ne, Ar, Kr, and Xe in the two lunar impact‐melt breccias Abar al’ Uj (AaU) 012 and Shişr 166 to obtain information on their cosmic‐ray exposure histories and possible launch pairing; the latter was suggested because of their similar chemical composition. AaU 012 has higher gas concentrations than Shişr 166 and clearly contains implanted solar wind gases, indicating a shallow to moderate shielding for this meteorite in the lunar regolith. The maximum shielding depth of AaU 012 was most likely ≤310 g cm−2 and its lunar regolith residence time was ≥420 ± 70 Ma. Our results indicate that in Shişr 166 the trapped component is a mixture of air and solar wind. The low concentration of cosmogenic and solar wind gases indicate substantial diffusive gas loss and a shielding depth of <700 g cm−2 on the Moon for Shişr 166. All differences seen in the concentrations and isotopic compositions of the noble gases suggest that AaU 012 and Shişr 166 are most likely not launch pairs, although a different exposure history on the Moon does not exclude the possibility that the two meteorites were ejected by a single, large impact event.
Analysis of TCP Performance over Mobile Ad Hoc Networks

Mobile ad hoc networks have attracted attention lately as a means of providing continuous network connectivity to mobile computing devices regardless of physical location. Recent research has focused primarily on the routing protocols needed in such an environment. In this paper, we investigate the effects that link breakage due to mobility has on TCP performance. Through simulation, we show that TCP throughput drops significantly when nodes move, due to TCP's inability to recognize the difference between link failure and congestion. We also analyze specific examples, such as a situation where throughput is zero for a particular connection. We introduce a new metric, expected throughput, for the comparison of throughput in multi-hop networks, and then use this metric to show how the use of explicit link failure notification (ELFN) techniques can significantly improve TCP performance.
Biomechanical and microstructural benefits of physical exercise associated with risedronate in bones of ovariectomized rats

Several treatments have been developed aiming the prevention of bone loss. There are discussions about the best prophylactic and therapeutic procedures for osteoporosis. This study evaluated the effects of physical exercise associated with risedronate as a prophylactic and therapeutic procedure in osteopenic bones of rats submitted to ovariectomy. We used 48 Wistar rats divided into: ovariectomized or subjected to sham surgery. Ovariectomized rats were divided into the following sub‐groups: OVX, 12 weeks sedentary; OVX‐EX, treadmill training for 12 weeks; OVX‐RA, 12 weeks with risedronate administration; and OVX‐EX‐RA, 12 weeks with risedronate administration and treadmill training. Rats subjected to sham surgery were divided into the following sub‐groups: SH, 12 weeks sedentary; SH‐EX, treadmill training for 12 weeks; SH‐RA, 12 weeks with risedronate administration; and SH‐EX‐RA, 12 weeks with risedronate administration and training on the treadmill. The effectiveness of the treatment was evaluated in tibias using biomechanical, radiological, histomorphometric, and immunohistochemical analyses. Data were analyzed by statistical tests, with significance level of P < 0.05. Results of mechanical tests showed that the SH‐RA group had lower values compared with OVX‐RA group; densitometry showed no significant differences; according to histomorphometric methods, OVX group presented lower results than the SH‐EX, OVX‐RA, SH‐EX‐RA, and OVX‐EX‐RA groups, and SH‐EX‐RA and OVX‐EX‐RA groups showed values higher than SH‐RA, SH, and OVX‐EX groups. The SH‐EX‐RA and OVX‐EX‐RA groups had decreased immunostaining for tartrate‐resistant acid phosphatase and receptor activator of nuclear factor kappa‐B ligand and increased osteoprotegerin immunostaining. In this experimental model, it was concluded that the physical training associated with use of risedronate exerted positive effects on biomechanical and microstructural properties in bones of ovariectomized rats. Microsc. Res. Tech. 77:431–438, 2014. © 2014 Wiley Periodicals, Inc.
Polarity Prediction Using Automatic Semantic Analysis on User Comments

Gauging the quality of a video or post by inspecting the user comments is a challenging task, as it requires reading through the comments. Over the years, researchers have employed various models to automatically identify the comments' polarity automatically. This paper explores how deep-learning models such as convolutional neural networks (CNNs) and long-short term memory (LSTM) models can perform polarity analysis on a collection of comments and how the results can be used to assign polarity to user comments automatically. To accomplish this goal, we utilize three labeled datasets: the Apple Twitter Sentiment Text dataset, the Airline Sentiment dataset, and a general Twitter dataset that contains positive, negative, and neutral sentiments. We develop a hybrid CNN-BiLSTM-based prediction model for polarity prediction and assess its performance using accuracy, precision, recall, and Fl-score measures. Additionally, we employ three feature extraction techniques (TF-IDF, bag-of-words, and Word2vec) and five machine learning models (K-nearest neighbors, support vector machine, naive Bayes, random forest, and XGBoost) to compare the performance of the CNN-BiLSTM model with these models. The results showed that the developed models achieved the best performance with the accuracy, precision, recall, and Fl-score values of 0.931, 0.939, 0.925, and 0.931, respectively. Among the used ML models, Random Forest with TF-IDF produced the best performance with the accuracy, precision, recall, and Fl-score values of 0.820, 0.830, 0.831, and 0.829, respectively. Other models performed moderately.
Maternal Depressive Symptoms and Children's Receipt of Health Care in the First 3 Years of Life

Background. Maternal depression is widely recognized to negatively influence mother-child interactions and children's behavior and development, but little is known about its relation to children's receipt of health care. Objective. To determine if maternal depressive symptoms reported at 2 to 4 and 30 to 33 months postpartum are associated with children's receipt of acute and preventive health care services in the first 30 months. Design. Cohort study of data collected prospectively as part of the National Evaluation of Healthy Steps for Young Children (HS). Data sources included medical records abstracted for the first 32 months, enrollment questionnaires, and parent interviews when children were 2 to 4 and 30 to 33 months old. Acute care use included hospitalizations and emergency department visits. Preventive care included well-child visits and vaccinations. Maternal depressive symptoms were assessed by using the Center for Epidemiologic Studies-Depression Scale. Generalized linear models (logistic regression for dichotomous outcomes and Poisson regression for count outcomes) were used to estimate the effect of maternal depressive symptoms on children's receipt of care. The models were adjusted for baseline demographic characteristics, child health status, participation in HS, and site of enrollment. Results. Of the 5565 families enrolled in HS, 88% completed 2- to 4-month parent interviews, 67% completed 30- to 33-month parent interviews, and 96% had medical records abstracted. The percentages of mothers reporting depressive symptoms were 17.8% at 2 to 4 months, 15.5% at 30 to 33 months, and 6.4% at both. Children whose mothers had depressive symptoms at 2 to 4 months had increased use of acute care reported at 30 to 33 months including emergency department visits in the past year (odds ratio [OR]: 1.44; confidence interval [CI]: 1.17, 1.76). These children also had decreased receipt of preventive services including age-appropriate well-child visits (eg, at 12 months [OR: 0.80; CI: 0.67, 0.95]) and up-to-date vaccinations at 24 months for 4 doses of diphtheria, tetanus, pertussis, 3 doses of polio vaccine, and 1 dose of measles-mumps-rubella (OR: 0.79; CI: 0.68, 0.93). There was no association of maternal depressive symptoms at 30 to 33 months with children's preceding use of care. Conclusions. Maternal depressive symptoms in early infancy contribute to unfavorable patterns of health care seeking for children. Increased provider training for recognizing maternal depressive symptoms in office settings, more effective systems of referral, and development of partnerships between adult and pediatric providers could contribute to enhanced receipt of care among young children.
Prevalence of hepatitis C virus (HCV) coinfection in HIV infected individuals in south India and characterization of HCV genotypes.

PURPOSE To determine anti-HCV antibodies and genomic subtype of HCV in 1487 confirmed human immunodeficiency virus (HIV) positive samples. METHODS A total of 1487 confirmed HIV-positive samples were tested for anti-HCV antibodies by using a third generation ELISA kit (Ortho 3.0) and by RT PCR for HCV. HIV and HCV coinfected samples were selected for HCV genotyping by RFLP and subtyping with NS5-type specific primers. RESULTS A total of 1487 HIV-infected serum samples were screened for HCV infection, of which, a 1443 (97.04%) were negative and 45 (3.02%) were coinfected. HIV-HCV coinfection was predominant in the age group 41-50 years (51.1%). HCV genotyping and subtyping was done for the 45 HCV RNA-positive specimens of which genotype 1 was observed in 31 (68.8%) and genotype 3 was observed in 14 (31.1%) subjects. Further subtyping analysis showed the genotype 1b in 23 (51.1%), 1a in eight (17.7%), 3a in 10 (22.2%) and 3b in four (8.8%) subjects. CONCLUSION HIV and HCV seroprevalence is higher in South India, and the most prevalent genotype in coinfection was genotype 1b.
A functional model for G protein activation of the muscarinic K+ channel in guinea pig atrial myocytes. Spectral analysis of the effect of GTP on single-channel kinetics

To elucidate the functional interaction between the active G protein subunit (GK*) and the cardiac muscarinic K+ (KACh) channel, the effect of intracellular GTP on the channel current fluctuation in the presence of 0.5 microM extracellular acetylcholine was examined in inside-out patches from guinea pig atrial myocytes using spectral analysis technique. The power density spectra of current fluctuations induced at various concentrations of GTP ([GTP]) were well fitted by the sum of two Lorentzian functions. Because the channel has one open state, the open-close transitions of the channel gate represented by the spectra could be described as C2<-->C1<-->O. As [GTP] was raised, the channel activity increased in a positive cooperative manner. The powers of the two Lorentzian components concomitantly increased, while the corner frequencies and the ratio of the powers at 0 Hz remained almost constant. This indicates that G protein activation did not affect the gating of each channel but mainly increased the number of functionally active channels in the patch to enhance the channel activity. Regulation of the number of functionally active channels could be described by a slow transition of the channel states, U (unavailable)<-- >A (available), which is independent of the gating. The equilibrium of this slow transition was shifted by GTP from U to A. Monod-Wyman- Changeux's allosteric model for the channel state transition(U<-->A) could well describe the positive cooperative increase in the channel availability by GTP, assuming that, in the presence of saturating concentrations of ACh, [GK*] linearly increased as [GTP] was raised in our experimental range. The model indicates that the cardiac KACh channel could be described as a multimer composed of four or more functionally identical subunits, to each of which one GK* binds.
Emx1-Lineage Progenitors Differentially Contribute to Neural Diversity in the Striatum and Amygdala

In the developing mammalian basal telencephalon, neural progenitors from the subpallium generate the majority of inhibitory medium spiny neurons (MSNs) in the striatum, while both pallial- and subpallial-derived progenitors contribute to excitatory and inhibitory neuronal diversity in the amygdala. Using a combination of approaches, including genetic fate mapping, cell birth dating, cell migration assays, and electrophysiology, we find that cells derived from the Emx1 lineage contribute to two distinct neuronal populations in the mature basal forebrain: inhibitory MSNs in the striatum and functionally distinct subclasses of excitatory neurons in the amygdala. Our cell birth-dating studies reveal that these two populations are born at different times during early neurogenesis, with the amygdala population born before the MSNs. In the striatum, Emx1-lineage neurons represent a unique subpopulation of MSNs: they are disproportionately localized to the dorsal striatum, are found in dopamine receiving, reelin-positive patches, and are born throughout striatal neurogenesis. In addition, our data suggest that a subpopulation of these Emx1-lineage cells originate in the pallium and subsequently migrate to the developing striatum and amygdala. Our intersectional fate-mapping analysis further reveals that Emx1-lineage cells that coexpress Dlx exclusively generate MSNs but do not contribute to the excitatory neurons in the amygdala. Thus, both the timing of neurogenesis and differential combinatorial gene expression appear to be key determinants of striatal versus amygdala fate decisions of Emx1-lineage cells.
(CORN)2: Correlation-based cooperative spectrum sensing in cognitive radio networks

In this paper, (CORN)2, a correlation-based, optimal sensing scheduling algorithm is developed for cognitive radio networks to minimize energy consumption. A sensing quality metric is defined as a measure of the correctness of spectral availability information. The optimal scheduling algorithm is shown to minimize the cost of sensing (e.g., energy consumption, sensing duration) while meeting the sensing quality requirements. To this end, (CORN)2 utilizes a novel sensing deficiency virtual queue concept and exploits the correlation between spectrum measurements of a particular secondary user and its collaborating neighbors. The proposed algorithm is further proved to achieve a distributed and optimal solution under certain, easily satisfied assumptions. In addition to the theoretically proved performance guarantees, the proposed algorithm is also evaluated through simulations.
A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for α- and β−-Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative

Terbium offers 4 clinically interesting radioisotopes with complementary physical decay characteristics: 149Tb, 152Tb, 155Tb, and 161Tb. The identical chemical characteristics of these radioisotopes allow the preparation of radiopharmaceuticals with identical pharmacokinetics useful for PET (152Tb) and SPECT diagnosis (155Tb) and for α- (149Tb) and β−-particle (161Tb) therapy. The goal of this proof-of-concept study was to produce all 4 terbium radioisotopes and assess their diagnostic and therapeutic features in vivo when labeled with a folate-based targeting agent. Methods: 161Tb was produced by irradiation of 160Gd targets with neutrons at Paul Scherrer Institute or Institut Laue-Langevin. After neutron capture, the short-lived 161Gd decays to 161Tb. 149Tb, 152Tb, and 155Tb were produced by proton-induced spallation of tantalum targets, followed by an online isotope separation process at ISOLDE/CERN. The isotopes were purified by means of cation exchange chromatography. For the in vivo studies, we used the DOTA–folate conjugate cm09, which binds to folate receptor (FR)–positive KB tumor cells. Therapy experiments with 149Tb-cm09 and 161Tb-cm09 were performed in KB tumor–bearing nude mice. Diagnostic PET/CT (152Tb-cm09) and SPECT/CT (155Tb-cm09 and 161Tb-cm09) studies were performed in the same tumor mouse model. Results: Carrier-free terbium radioisotopes were obtained after purification, with activities ranging from approximately 6 MBq (for 149Tb) to approximately 15 GBq (for 161Tb). The radiolabeling of cm09 was achieved in a greater than 96% radiochemical yield for all terbium radioisotopes. Biodistribution studies showed high and specific uptake in FR-positive tumor xenografts (23.8% ± 2.5% at 4 h after injection, 22.0% ± 4.4% at 24 h after injection, and 18.4% ± 1.8% at 48 h after injection). Excellent tumor-to-background ratios at 24 h after injection (tumor to blood, ∼15; tumor to liver, ∼5.9; and tumor to kidney, ∼0.8) allowed the visualization of tumors in mice using PET (152Tb-cm09) and SPECT (155Tb-cm09 and 161Tb-cm09). Compared with no therapy, α- (149Tb-cm09) and β−-particle therapy (161Tb-cm09) resulted in a marked delay in tumor growth or even complete remission (33% for 149Tb-cm09 and 80% for 161Tb-cm09) and a significantly increased survival. Conclusion: For the first time, to our knowledge, 4 terbium radionuclides have been tested in parallel with tumor-bearing mice using an FR targeting agent. Along with excellent tumor visualization enabled by 152Tb PET and 155Tb SPECT, we demonstrated the therapeutic efficacy of the α-emitter 149Tb and β−-emitter 161Tb.
Innovation, Ownership and Profitability Innovation, Ownership and Profitability

This paper considers the relationship between innovation, ownership and profitability for a panel of manufacturing plants in Ireland and Northern Ireland. Previous literature suggests that innovators are persistently more profitable than non-innovators, but little is known about how this link is moderated by external versus domestic ownership. We consider the link between innovation and profits separately for innovators and non-innovators, and for indigenous innovators and noninnovators and externally-owned plants. We also consider the determinants of innovation over the distribution of plant-level profitability, and find that the determinants of profitability – including innovation and external ownership – vary over the distribution from low to high profitability plants. We find support for the view that innovators and non-innovators have different profitability determinants, and that the profitability of externally-owned plants depends on very different factors to that of indigenously-owned enterprises.