Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of similarity between elemental stimuli and compounds in olfactory patterning discriminations.

We studied the ability of honeybees to discriminate between single odorants and binary olfactory mixtures. We analyzed the effect of the number of common elements between these two stimulus classes on olfactory discrimination. We used olfactory conditioning of the honeybees' proboscis extension reflex (PER), a paradigm in which odors can be associated with a reinforcement of sucrose solution. Bees were asked to discriminate reinforced from nonreinforced olfactory stimuli. They were trained with two elemental odors (A and B) versus a binary olfactory mixture. The mixture was either AB (group 2CE, two common elements), AC (group 1CE, one common element A), or CD (group 0CE, no common element). Three groups followed a positive patterning schedule (mixture reinforced and elements nonreinforced: groups 2CE+, 1CE+, and 0CE+) and three other groups a negative patterning schedule (mixture nonreinforced and elements reinforced: groups 2CE-, 1CE-, and 0CE-). We showed that a reduction of similarity (number of common elements) between elemental odors and compounds enhanced the ability to discriminate elements from compounds and that the kind of compound processing used by the bees supports theories that assume nonelemental compound processing (i.e., that exclude the mere summation of the elemental associative strengths upon compound presentation).
Contrasting Thoughts About Deceptive Orchids: A Response to Sobel and Randle

Sobel and Randle (2009) challenge several methodological choices in the comparative study of the evolution of reproductive isolation in Mediterranean deceptive orchids of Scopece et al. (2007) including the species concept used and the selection of taxa, together with the perceived comparison of clades of different ages. They further criticize that pollinator information was taken from the literature and that two different methods were used to estimate pollinator specificity in food-deceptive and sexually deceptive orchids, respectively. Here we reply to these challenges.
N‐acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure

Oxidative stress plays a central role in the pathogenesis of heart failure. We aimed to determine whether the antioxidant N‐acetylcysteine can attenuate cardiac fibrosis and remodeling in a mouse model of heart failure. Minipumps were implanted subcutaneously in wild‐type mice (n = 20) and mice with cardiomyopathy secondary to cardiac specific overexpression of mammalian sterile 20‐like kinase 1 (MST‐1; n = 18) to administer N‐acetylcysteine (40 mg/kg per day) or saline for a period of 8 weeks. At the end of this period, cardiac remodeling and function was assessed via echocardiography. Fibrosis, oxidative stress, and expression of collagen types I and III were quantified in heart tissues. Cardiac perivascular and interstitial fibrosis were greater by 114% and 209%, respectively, in MST‐1 compared to wild type (P ≤ 0.001). In MST‐1 mice administered N‐acetylcysteine, perivascular and interstitial fibrosis were 40% and 57% less, respectively, compared to those treated with saline (P ≤ 0. 03). Cardiac oxidative stress was 119% greater in MST‐1 than in wild type (P < 0.001) and N‐acetylcysteine attenuated oxidative stress in MST‐1 by 42% (P = 0.005). These data indicate that N‐acetylcysteine can blunt cardiac fibrosis and related remodeling in the setting of heart failure potentially by reducing oxidative stress. This study provides the basis to investigate the role of N‐acetylcysteine in chronic heart failure.
Functional reorganisation of memory after traumatic brain injury: a study with H2150 positron emission tomography

Objective: To study the effects of moderate to severe traumatic brain injury (TBI) on the functional neuroanatomy supporting memory retrieval. Methods: Subjects were six patients who had sustained a moderate to severe TBI about four years before scanning and had since made a good recovery. Eleven healthy young adults matched to the patients for age and education served as controls. An established H2150 positron emission tomography paradigm was used to elicit brain activations in response to memory retrieval. TBI patients' patterns of brain activation were compared statistically with those of control subjects. Both group and individual case data were analysed. Results: Both TBI patients and controls engaged frontal, temporal, and parietal regions known to be involved in memory retrieval, yet the TBI patients showed relative increases in frontal, anterior cingulate, and occipital activity. The hemispheric asymmetry characteristic of controls was attenuated in patients with TBI. Reduced activation was noted in the right dorsomedial thalamus. Although local aspects of this pattern were affected by the presence of focal lesions and performance differences, the overall pattern was reliable across patients and comparable to functional neuroimaging results reported for normal aging, Alzheimer's disease, and other patients with TBI. Conclusions: The TBI patients performed memory tasks using altered functional neuroanatomical networks. These changes are probably the result of diffuse axonal injury and may reflect either cortical disinhibition attributable to disconnection or compensation for inefficient mnemonic processes.
The Emperor's New Clothes revisited, or reflections on the pathogenesis of dengue hemorrhagic fever.

As most of you know, one of the duties of the President of the American Society of Tropical Medicine and Hygiene specified by the by-laws is the presentation of an address at the annual meet ing. I do not know what type of address those responsible for this provision had in mind, but a review of previous presidential addresses reveals a wide variety both of philosophical and scientific topics. Since I do not feel competent to address you on a philosophical subject, I have chosen to review a scientific topic which has been of interest to me during the past few years. In making this choice, I know that the subject matter will be of relatively little interest to those of you in other fields and for this I apologize. I shall illustrate later, however, that the topic I have chosen is especially appropriate for the site of our gathering this year and for the bicentennial which our joint meeting commemorates. Those of you unfamiliar with recent work and discussions on dengue may be puzzled by the first part of the title of this address. I should like to explain that it was chosen to call attention to what I believe is the transparency of arguments used in support of a widely disseminated hypoth esis on the pathogenesis of dengue hemorrhagic feverâ€”but that it was not intended that the analogy be carried so far as to imply that those who have proposed this hypothesis are the counter parts of the two rogues in Hans Christian Ander sen's story. ' There has been considerable speculation as to why dengue, long considered an annoying but benign disease, has in the last 20 years become a leading cause of hospitalization and death among children in a number of Southeast Asian countries.2 The life-threatening forms of dengue usually are associated with hemorrhage, hypovolemic shock,
Biodiversity and ecosystem management in the Iraqi marshlands : screening study on potential World Heritage nomination

This report includes an inventory of data and information on the Iraqi marshland ecosystem; technical guidance on the assessment framework and tools for ecosystem management and biodiversity conservation with regard to the requirements for World Heritage nomination; and guidance on the development of a network in the field of ecosystem management and biodiversity conservation which would contribute to the planning, implementation and monitoring the long-term management of the Iraqi marshlands, in relation to possible next steps in the World Heritage nomination process.
Dynamical parameter determinations in Pluto’s system - Expected constraints from the New Horizons mission to Pluto

Pluto is the multiple system that has been observed the longest. Yet, the masses of its smallest satellites, Nix and Hydra, which were discovered in 2005, are still imprecisely known, because of the short time span and number of available observations. We present a numerical model that takes into account the second order gravity fields and Pluto's orbital motion in the solar system. We investigated the dynamical parameters that may be reliably determined today. We also assessed the possible improvements on the parameter uncertainties with the future increase of observations, including the New Horizons mission. Fitting our model to simulated data, we show that the precision of observations prevents the quantification of the polar oblateness J2 and equatorial bulge c22 of Pluto and Charon. Similarly, we show that the masses are on the detection limit. In particular, unless 25 observations are made every year, the mass of Nix may be constrained with confidence only with New Horizons data. Hydra's mass will only be constrained by the probe. The recent discovery of P4 might change this situation, but our knowledge of this object is still too vague to draw any conclusion.
Racial/Ethnic Differences in the Prevalence of Clinically Recognized Alcohol Use Disorders Among Patients from the U.S. Veterans Health Administration.

BACKGROUND Alcohol use disorders (AUDs) are common and have worse consequences for racial/ethnic minority groups than whites. AUDs are often underrecognized in clinical settings, but it is unknown whether the prevalence of clinically recognized AUD varies across racial/ethnic groups. We describe the overall and age- and gender-stratified prevalence of clinically documented AUD across 3 racial/ethnic groups in a national sample of Veterans Health Administration (VA) patients. METHODS Data from VA's National Patient Care Database identified all patients who used VA care in Fiscal Year 2012 and were documented as black, Hispanic, or white race/ethnicity. The prevalence of clinically recognized AUD based on ICD-9 diagnoses was compared across racial/ethnic groups overall and within gender and age groups using chi-square tests of independence. RESULTS Among 4,666,403 eligible patients, 810,902 (17.4%) were black, 302,331 (6.5%) were Hispanic, and 3,553,170 (76.1%) were white. The prevalence of clinically recognized AUD was 6.5% overall, and 9.8% (95% CI 9.8 to 9.9) among black, 7.1% (95% CI 7.0 to 7.2) among Hispanic, and 5.7% (95% CI 5.6 to 5.7) among white patients (p < 0.001). This pattern generally held for men, regardless of age group, with the exception of those 18 to 29 years old, for whom no difference was observed across race/ethnicity. Among women, the prevalence of AUD was generally lowest among Hispanic and highest among black patients, with the exception of those 30 to 44 years old, for whom the highest prevalence was among whites. CONCLUSIONS In contrast to findings from the general population, the prevalence of clinically recognized AUD among VA patients is generally highest among black men and women and lowest among white men and Hispanic women. This is the first study to describe the prevalence of clinically recognized AUD across racial/ethnic groups in a large healthcare system. Future research comparing estimates to diagnoses based on structured gold-standard assessments is needed to understand whether AUDs are under- or overidentified.
The Cytochrome P450 Lanosterol 14α-Demethylase Gene Is a Demethylation Inhibitor Fungicide Resistance Determinant in Monilinia fructicola Field Isolates from Georgia

ABSTRACT Resistance in Monilinia fructicola to demethylation inhibitor (DMI) fungicides is beginning to emerge in North America, but its molecular basis is unknown. Two potential genetic determinants of DMI fungicide resistance including the 14α-demethylase gene (MfCYP51) and the ATP-binding cassette transporter gene MfABC1, were investigated in six resistant (DMI-R) and six sensitive (DMI-S) field isolates. No point mutations leading to an amino acid change were found in the MfCYP51 gene. The constitutive expression of the MfCYP51 gene in DMI-R isolates was significantly higher compared to DMI-S isolates. Gene expression was not induced in mycelium of DMI-R or DMI-S isolates treated with 0.3 μg of propiconazole/ml. A slightly higher average MfCYP51 copy number value was detected in DMI-R isolates (1.35) compared to DMI-S isolates (1.13); however, this difference could not be verified in Southern hybridization experiments or explain the up to 11-fold-increased MfCYP51 mRNA levels in DMI-R isolates. Analysis of the upstream nucleotide sequence of the MfCYP51 gene revealed a unique 65-bp repetitive element at base pair position −117 from the translational start site in DMI-R isolates but not in DMI-S isolates. This repetitive element contained a putative promoter and was named Mona. The link between Mona and the DMI resistance phenotype became even more apparent after studying the genetic diversity between the isolates. In contrast to DMI-S isolates, DMI-R isolates contained an MfCYP51 gene of identical nucleotide sequence associated with Mona. Still, DMI-R isolates were not genetically identical as revealed by Microsatellite-PCR analysis. Also, real-time PCR analysis of genomic DNA indicated that the relative copy number of Mona among DMI-S and DMI-R isolates varied, suggesting its potential for mobility. Interestingly, constitutive expression of the MfABC1 gene in DMI-R isolates was slightly lower than that of DMI-S isolates, but expression of the MfABC1 gene in DMI-R isolates was induced in mycelium after propiconazole treatment. Therefore, the MfABC1 gene may play a minor role in DMI fungicide resistance in M. fructicola. Our results strongly suggest that overexpression of the MfCYP51 gene is an important mechanism in conferring DMI fungicide resistance in M. fructicola field isolates from Georgia and that this overexpression is correlated with Mona located upstream of the MfCYP51 gene.
Spectral Doppler Interrogation of Mitral Regurgitation —Spot Diagnosis

Mitral regurgitation (MR) is one of the most common valvular lesions that are readily identified by transthoracic echocardiography. Color Doppler imaging is the modality of choice for the recognition of MR, and it plays an important role in the assessment of regurgitation severity. Continuous wave (CW) Doppler is commonly used to interrogate the MR signal, and this modality can provide highly useful data regarding several physiological and pathological parameters. In this manuscript, we present a series of cases that illustrate the various hemodynamic parameters that can be derived from analysis of the CW Doppler signal of MR.
Effect of a High Intake of Conjugated Linoleic Acid on Lipoprotein Levels in Healthy Human Subjects

Background Trans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower high-density lipoprotein (HDL) cholesterol, raise low-density lipoprotein (LDL) cholesterol, and increase the risk of coronary heart disease. The effects of trans fatty acids from ruminants are less clear. We investigated the effect on blood lipids of cis-9, trans-11 conjugated linoleic acid (CLA), a trans fatty acid largely restricted to ruminant fats. Methodology/Principal Findings Sixty-one healthy women and men were sequentially fed each of three diets for three weeks, in random order, for a total of nine weeks. Diets were identical except for 7% of energy (approximately 20 g/day), which was provided either by oleic acid, by industrial trans fatty acids, or by a mixture of 80% cis-9, trans-11 and 20% trans-10, cis-12 CLA. After the oleic acid diet, mean (± SD) serum LDL cholesterol was 2.68±0.62 mmol/L compared to 3.00±0.66 mmol/L after industrial trans fatty acids (p<0.001), and 2.92±0.70 mmol/L after CLA (p<0.001). Compared to oleic acid, HDL-cholesterol was 0.05±0.12 mmol/L lower after industrial trans fatty acids (p = 0.001) and 0.06±0.10 mmol/L lower after CLA (p<0.001). The total-to–HDL cholesterol ratio was 11.6% higher after industrial trans fatty acids (p<0.001) and 10.0% higher after CLA (p<0.001) relative to the oleic acid diet. Conclusions/Significance High intakes of an 80∶20 mixture of cis-9, trans-11 and trans-10, cis-12 CLA raise the total to HDL cholesterol ratio in healthy volunteers. The effect of CLA may be somewhat less than that of industrial trans fatty acids. Trial Registration ClinicalTrials.gov NCT00529828
Insulin-Like Growth Factor I Protects Oligodendrocytes from Tumor Necrosis Factor-α-Induced Injury.

Tumor necrosis factor-alpha (TNF-alpha) has been causally implicated in several demyelinating disorders, including multiple sclerosis. Because insulin-like growth factor I (IGF-I) is a potent stimulator of myelination, we investigated whether it can protect oligodendrocytes and myelination from TNF-alpha-induced damage using mouse glial cultures as a model. Compared with controls, TNF-alpha decreased oligodendrocyte number by approximately 40% and doubled the number of apoptotic oligodendrocytes and their precursors. Addition of Boc-aspartyl(Ome)-fluoromethyl ketone (BAF), an inhibitor of interleukin-1beta converting enzyme (ICE)/caspase proteases, blocked TNF-alpha-induced reductions in oligodendrocytes, indicating that the TNF-alpha-induced reduction in oligodendrocytes is, at least in part, due to apoptosis, and that ICE/caspases are one of TNF-alpha action mediators. Simultaneous addition of IGF-I to TNF-alpha-treated cultures negated these TNF-alpha effects nearly completely. Furthermore, IGF-I promoted oligodendrocyte precursor proliferation and/or differentiation in TNF-alpha-treated cultures. To analyze TNF-alpha and IGF-I actions on oligodendrocyte function, we measured the abundance of messenger RNAs (mRNAs) for two major myelin-specific proteins, myelin basic protein (MBP) and proteolipid protein (PLP). While TNF-alpha decreased MBP and PLP mRNA abundance by 5- to 6-fold, IGF-I abrogated TNF-alpha-induced reductions in a dose- and time-dependent manner. The changes in MBP and PLP mRNA abundance could not be completely explained by the changes in oligodendrocyte number, indicating that myelin protein gene expression is regulated by both TNF-alpha and IGF-I. These data support the hypothesis that TNF-alpha can mediate oligodendrocyte and myelin damage, and indicate that IGF-I protects oligodendrocytes from TNF-alpha insults by blocking TNF-alpha-induced apoptosis, and by promoting oligodendrocyte and precursor proliferation/differentiation and myelin protein gene expression.
Thin slices of interaction: predicting users' task difficulty within 60 sec.

We report on an exploratory study where the first 60 seconds of the video recording of a user interaction are used to predict the user's experienced task difficulty. This approach builds on previous work on ""thin slices"" of human-human behavior, and applies it to human-computer interaction. In the scenario of interacting with a photocopy machine, automated video coding showed that the Activity and Emphasis predicted 46.6% of the variance of task difficulty. This result closely follows reported results on predicting negotiation outcomes from conversational dynamics using similar variables on the speech signal.
A comparison of energy expenditure by a high level trans-femoral amputee using the Intelligent Prosthesis and conventionally damped prosthetic limbs

Comparisons were made between the Intelligent Prosthesis (IP), Mauch and pneumatic swing phase control damping systems on the same prosthesis worn by a high level trans-femoral amputee. Speeds self selected by corridor walking (4.4 – 5.5 kmh−1) proved not to be sustainable for treadmill walking. Comfortable speeds were attained when the subject walked on a treadmill at 2.0, 2.6 and 3.2 kmh−1 in two tests for each prosthesis type. Oxygen uptake (V˙O 2), cadence and heart rate were measured over 5 minute walks interspersed with rest periods. Spearman's correlation was used to test for differences between prosthesis types at each speed. At the two slower speeds no significant difference was found, but at the higher speed of 3.2 kmh−1, the IP was associated with a significantly lower V˙O2 (p<0.05). A two way analysis of variance with replication (ANOVA) demonstrated a significant difference between VO 2 for different limb types (p=0.015). A square law function was fitted to the mean V˙O 2 for each prosthesis type by the method of least squares regression. ANOVA demonstrated a significant difference between velocity coefficients for the different prosthesis types (p<0.05). Cadence was almost constant during the period of each walk, varying by 1 step min−1 at most. However the test-retest differences in cadence were considerable. It is concluded that there was little difference in energy expenditure between prosthesis types at slower speeds, but at higher speeds (=>3.2km h−1) the IP gave a lower oxygen uptake by about 10%.
The provenance of erratic pebbles from a till in the vicinity of the city of Radom, central Poland

Petrographic analysis, including the indicator erratics count method of coarse pebbles (20–60 mm), was performed for the first subsurface layer of the glacial till in the vicinity of the city of Radom. Crystalline rocks comprise 60% of the sample, whereas carbonate and clastic sedimentary rocks total 18% and 15%, respectively. Among the crystalline rocks, 14% clasts were identified as indicator erratics. The majority of the indictor erratics originated from the Aland region (63%). Significant contributions were also derived from the central Baltic Basin (12%), Angermanland (9%) and Uppland (9%) regions. Trace amounts are recorded from the northern Baltic, Dalarna and Smaland regions. The spatial distribution of crystalline erratic source areas suggests material incorporation into an ice sheet mainly from central-eastern Fennoscandia. The indicator assemblage composition indicates the Odranian (MIS 6) origin of the till. The majority of the erratic sedimentary rocks were derived from the central and southern Baltic Basin while local rocks comprise a minor proportion. The relatively low carbonate clasts content indicates that the till was affected by partial decalcification resulting from post-depositional chemical weathering. This study supplements the results on erratic pebble provenance in the glacial tills of Middle Polish Glaciation Complex in Poland.
ALMA spectral survey of Supernova 1987A – molecular inventory, chemistry, dynamics and explosive nucleosynthesis

We report the first molecular line survey of Supernova 1987A in the millimetre wavelength range. In the ALMA 210--300 and 340--360 GHz spectra, we detected cold (20--170 K) CO, 28SiO, HCO+ and SO, with weaker lines of 29SiO from ejecta. This is the first identification of HCO+ and SO in a young supernova remnant. We find a dip in the J=6--5 and 5--4 SiO line profiles, suggesting that the ejecta morphology is likely elongated. The difference of the CO and SiO line profiles is consistent with hydrodynamic simulations, which show that Rayleigh-Taylor instabilities cause mixing of gas, with heavier elements much more disturbed, making more elongated structure. We obtained isotopologue ratios of 28SiO/29SiO>13, 28SiO/30SiO>14, and 12CO/13CO>21, with the most likely limits of 28SiO/29SiO>128, 28SiO/30SiO>189. Low 29Si and 30Si abundances in SN 1987A are consistent with nucleosynthesis models that show inefficient formation of neutron-rich isotopes in a low metallicity environment, such as the Large Magellanic Cloud. The deduced large mass of HCO+ (~5x10^-6 Msun) and small SiS mass (<6x10^-5 Msun) might be explained by some mixing of elements immediately after the explosion. The mixing might have caused some hydrogen from the envelope to sink into carbon and oxygen-rich zones after the explosion, enabling the formation of a substantial mass of HCO+. Oxygen atoms may have penetrated into silicon and sulphur zones, suppressing formation of SiS. Our ALMA observations open up a new window to investigate chemistry, dynamics and explosive-nucleosynthesis in supernovae.