Miracle-dz/UniFAR-FTUs huggingface dataset:
Overcoming status quo bias in the human brain

Humans often accept the status quo when faced with conflicting choice alternatives. However, it is unknown how neural pathways connecting cognition with action modulate this status quo acceptance. Here we developed a visual detection task in which subjects tended to favor the default when making difficult, but not easy, decisions. This bias was suboptimal in that more errors were made when the default was accepted. A selective increase in subthalamic nucleus (STN) activity was found when the status quo was rejected in the face of heightened decision difficulty. Analysis of effective connectivity showed that inferior frontal cortex, a region more active for difficult decisions, exerted an enhanced modulatory influence on the STN during switches away from the status quo. These data suggest that the neural circuits required to initiate controlled, nondefault actions are similar to those previously shown to mediate outright response suppression. We conclude that specific prefrontal-basal ganglia dynamics are involved in rejecting the default, a mechanism that may be important in a range of difficult choice scenarios.
Elevated Levels of the 64-kDa Cleavage Stimulatory Factor (CstF-64) in Lipopolysaccharide-stimulated Macrophages Influence Gene Expression and Induce Alternative Poly(A) Site Selection*

Lipopolysaccharide (LPS) activation of murine RAW 264.7 macrophages influences the expression of multiple genes through transcriptional and post-transcriptional mechanisms. We observed a 5-fold increase in CstF-64 expression following LPS treatment of RAW macrophages. The increase in CstF-64 protein was specific in that several other factors involved in 3′-end processing were not affected by LPS stimulation. Activation of RAW macrophages with LPS caused an increase in proximal poly(A) site selection within a reporter mini-gene containing two linked poly(A) sites that occurred concomitant with the increase in CstF-64 expression. Furthermore, forced overexpression of the CstF-64 protein also induced alternative poly(A) site selection on the reporter minigene. Microarray analysis performed on CstF-64 overexpressing RAW macrophages revealed that elevated levels of CstF-64 altered the expression of 51 genes, 14 of which showed similar changes in gene expression with LPS stimulation. Sequence analysis of the 3′-untranslated regions of these 51 genes revealed that over 45% possess multiple putative poly(A) sites. Two of these 51 genes demonstrated alternative polyadenylation under both LPS-stimulating and CstF-64-overexpressing conditions. We concluded that the physiologically increased levels of CstF-64 observed in LPS-stimulated RAW macrophages contribute to the changes in expression and alternative polyadenylation of a number of genes, thus identifying another level of gene regulation that occurs in macrophages activated with LPS.
Start‐up flow in a three‐dimensional lid‐driven cavity by means of a massively parallel direction splitting algorithm

The purpose of this paper is to validate a new highly parallelizable direction splitting algorithm. The parallelization capabilities of this algorithm are illustrated by providing a highly accurate solution for the start‐up flow in a three‐dimensional impulsively started lid‐driven cavity of aspect ratio 1 × 1 × 2 at Reynolds numbers 1000 and 5000. The computations are done in parallel (up to 1024 processors) on adapted grids of up to 2 billion nodes in three space dimensions. Velocity profiles are given at dimensionless times t = 4, 8, and 12; at least four digits are expected to be correct at Re = 1000. Copyright © 2011 John Wiley & Sons, Ltd.
Identification of Potential Pharmacological Targets by Analysis of the Comprehensive G Protein-Coupled Receptor Repertoire in the Four Cardiac Chambers

Cardiac function is regulated by many hormones and neurotransmitters that exert their physiological effects through the activation of G protein-coupled receptors (GPCRs). Identification of new GPCRs that might display a specific pattern of expression within the heart and differentially regulate specific cardiac functions represents an important issue for the development of new drugs. Indeed, highly targeted receptors represent only a small percentage of known GPCRs. Here, we quantified the expression of 395 endoGPCRs (all GPCRs excluding taste and odorant receptors) in male mouse right and left atria and ventricles by using high-throughput real-time reverse-transcriptase polymerase chain reaction (RT-PCR) and focused on the 135 most highly expressed transcripts. No cardiac functional data are available for almost half of these receptors; therefore, linking GPCR expression patterns to cardiac function has allowed us to provide new insights into the possible function of some of these receptors. Indeed, ventricles and atria are both contractile; however, the latter, and especially the right atrium, are central to the generation and regulation of cardiac rhythm. Accordingly, the right atrium exhibited the most specific signature, whereas the majority of GPCRs found in ventricles were evenly expressed in both the right and left chambers. RT-PCR data were confirmed at the protein level for six selected transcripts. Furthermore, we provide new data showing that, as suggested by our repertoire, the metabotropic glutamate receptor 1b is expressed and is functional in ventricular cardiac myocytes. This is the first report describing GPCRs in the four cardiac chambers and may assist in the identification of therapeutic targets.
Descemetic DALK and Predescemetic DALK: Outcomes in 236 Cases of Keratoconus

Purpose: To report the outcomes of our experience with deep anterior lamellar keratoplasty (DALK) in patients with keratoconus. Methods: A retrospective evaluation of 236 eyes of 198 patients that have undergone DALK between 2000 and 2006 using the Tsubota, Sugita, Melles, or Anwar technique. We analyzed the frequency of true Descemet membrane exposure, which we termed dDALK, and the number of eyes in which a predescemetic plane was achieved, which we termed pdDALK. Pre- and postoperative visual acuity, endothelial cell count, and central corneal thickness were evaluated on 120 eyes followed in our department. Results: A total of 139 of 236 (59%) eyes were classified as dDALK, with the Anwar technique showing the highest incidence of exposure of Descemet's membrane (127 of 164, 77%). Descemet ruptures occurred in 25 of 236 cases (10.5%). Three ruptures were converted to penetrating keratoplasty (PK). There was no difference in visual acuity between the pdDALK and dDALK groups at an average follow-up of 30.4 months, although the eyes in the dDALK group seemed to have faster visual recovery. Best spectacle corrected visual acuity postoperatively was at least 20/30 in 80-85% of eyes at the patient's last visit. Endothelial cell loss was 11-13%, with most of the loss occurring in the first 6 months. Conclusions: Performing DALK, we had the greatest likelihood of reaching Descemet's membrane with the Anwar Big Bubble technique. The visual outcomes are comparable to standard PK, avoiding the risk of endothelial rejection. Endothelial cell loss was low and the cell count was stable after 6 months.
Effects of bovine luteinizing hormone and human chorionic gonadotrophin on the bovine corpus luteum in vivo.

The steroidogenic effects of bovine luteinizing hormone (lh) and human chorionic gonadotrophin (hcg) in vivo were investigated by measuring the concentration of progesterone in peripheral plasma as an index of luteal secretory activity. The gonadotrophins were injected intravenously on Days 5, 10, 15 and 20 of the oestrous cycle, and serial samples of peripheral blood obtained before and after the injections. The steroidogenic response to lh or hcg was variable. Statistically significant increases in plasma progesterone levels were produced in five out of ten experiments; the magnitude of this increase was less than 100% in three cases and the duration of stimulation was less than 3 hr in four cases. The life-span of the corpus luteum was prolonged and new ovulations were induced by the gonadotrophins.
Refractive error and visual impairment in school children in Northern Ireland

Aims To describe the prevalence of refractive error (myopia and hyperopia) and visual impairment in a representative sample of white school children. Methods The Northern Ireland Childhood Errors of Refraction study, a population-based cross-sectional study, examined 661 white 12–13-year-old and 392 white 6–7-year-old children between 2006 and 2008. Procedures included assessment of monocular logarithm of the minimum angle of resolution (logMAR), visual acuity (unaided and presenting) and binocular open-field cycloplegic (1% cyclopentolate) autorefraction. Myopia was defined as −0.50DS or more myopic spherical equivalent refraction (SER) in either eye, hyperopia as ≥+2.00DS SER in either eye if not previously classified as myopic. Visual impairment was defined as >0.30 logMAR units (equivalent to 6/12). Results Levels of myopia were 2.8% (95% CI 1.3% to 4.3%) in younger and 17.7% (95% CI 13.2% to 22.2%) in older children: corresponding levels of hyperopia were 26% (95% CI 20% to 33%) and 14.7% (95% CI 9.9% to 19.4%). The prevalence of presenting visual impairment in the better eye was 3.6% in 12–13-year-old children compared with 1.5% in 6–7-year-old children. Almost one in four children fails to bring their spectacles to school. Conclusions This study is the first to provide robust population-based data on the prevalence of refractive error and visual impairment in Northern Irish school children. Strategies to improve compliance with spectacle wear are required.
[Association of polymorphisms of human leucocyte antigen -DRB1 and -DQA1 allele with outcomes of hepatitis B virus infection in Han population of north China].

OBJECTIVE To assess the association of polymorphisms of human leucocyte antigen (HLA) -DRB1 and -DQA1 region allele with outcomes of hepatitis B virus (HBV) infection in Han population of north China. METHODS A total of 207 chronic hepatitis B (HB) patients, 212 chronic asymptomatic HBV carriers (HBV carrier), and 148 self-limited HBV infection were recruited to examine the association between gene polymorphisms and outcomes of HBV infection. Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used to genotype HLA-DRB1 and HLA-DQA1 loci. RESULTS The frequency of HLA-DQA1 * 0301 in chronic HB patients (14.81%) was significantly lower than those in HBV carriers (25.24%) and self-limited HBV infection subjects (25.00%) (Pc = 0.002; Pc = 0.007). The frequency of HLA-DQA1 * 0102 in self-limited HBV infection subjects (8.78%) was significantly higher than those in chronic HB patients (2.18%) and HBV carriers (1.89%) (Pc = 0.000; P = 0.000). In addition, the frequency of HLA-DQA1 * 0302 in self-limited HBV infection subjects (4.05%) was significantly lower than that in chronic HB patients (11.41%) (Pc = 0.005). HLA-DQA1 * 0302 was demonstrated to be risk factors of chronic HBV (OR = 3.913, P = 0.0006), while HLA-DQA1* 0102 and HLA-DQA1 * 0301 to be protective factors against chronic HBV (OR = 0.200, P = 0.0004; OR = 0.258, P = 0.0000) after age, sex, smoking and drinking were adjusted by logistic regression analysis. There were positive interactions between drinking and HLA-DQA1 * 0102 [interaction index (II) = 1.49] or HLA-DQA1 * 0302 (II = 12.12). There were negative interactions between drinking and HLA-DQA1 * 0301 (II = 0.78) CONCLUSIONS The subjects with HLA-DQA1 * 0302 allele have an increased risk to chronic HB infection compared with other subjects without this allele, while HLA-DQA1 * 0301 and HLA-DQA1 * 0102 are associated with HBV clearness. Gene-environment interaction can affect the outcomes of HBV infection.
On Some Optimal Stopping Problems with Constraint

We consider the optimal stopping problem of a Markov process $\{x_t:t\ge0\}$ when the controller is allowed to stop only at the arrival times of a signal, that is, at a sequence of instants $\{\tau_n:n\ge1\}$ independent of $\{x_t:t\ge0\}$. We solve in detail this problem for general Markov--Feller processes with compact state space when the interarrival times of the signal are independent identically distributed random variables. In addition, we discuss several extensions to other signals and to other cases of state spaces. These results generalize the works of several authors where $\{x_t:t\ge0\}$ was a diffusion process and where the signal arrives at the jump times of a Poisson process.
A review of familial, genetic, and congenital aspects of primary varicose vein disease.

Varicose veins are a common manifestation of chronic venous disease (CVD) and present as excessively dilated, tortuous, and elongated superficial veins in the lower limbs. Varicose veins arise either secondary to vein wall remodeling or valvular incompetence leading to blood stasis and venous hypertension.1 Patients may experience lower limb pain, muscle cramps, bleeding, swelling, and skin changes, which include lipodermatosclerosis and eventual ulceration.2 To date, no specific cause for the development of varicose veins has been identified. However, various genetic and environmental risk factors have been ascribed to their formation. Primary varicose veins have been shown to affect up to one third of the Western adult population and are a major cause of morbidity. Estimates of prevalence range from 2% to 56% in men and 1% to 60% in women.3,4 This inconsistency between reports may be due to heterogeneity of study populations, study designs, and experimental methodologies used as well as actual variations in the general population. Some reports suggest that varicose veins are more common in women than men,5–8 whereas others have shown the opposite.2,3,9,10 A cross-sectional survey in Edinburgh, UK, involving a total of 1566 patients, showed an age-adjusted prevalence of Grade 1 truncal varices in 33.3% of men compared with 26.2% of women.10 It has also been reported that there is a significant correlation between CVD onset and sex with females showing first symptoms at a mean age of 30.8 years and males at 36.8 years.8 Besides sex, the prevalence of varicose veins increases with age. The Edinburgh Vein Study reported the prevalence of varicose veins increases from 11.5% in 18 to 24 year olds age to 55.7% in 55 to 64 year olds.10 Similarly, other studies have reported …
Toward a Cognitive Semantics: Typology and Process in Concept Structuring

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Contact lens-related adverse events and the silicone hydrogel lenses and daily wear care system used.

OBJECTIVE To investigate the incidence of adverse events related to the use of varying silicone hydrogel contact lens and lens solution combinations. METHODS Individuals with myopia (N = 558) participated in 1 or more of approximately 40-participant trials in a matrix of 20 silicone hydrogel contact lens and lens-solution combinations. Visits were at baseline, 2 weeks, 1 month, and 3 months. The mean study completion rate was 90% of the expected participant-months (final data set: 840 lens-solution combinations and 2271 participant-months). Adverse events were reported as the first occurrence of each type per 100 participant-months for each lens-solution combination. RESULTS The rate of all corneal infiltrative events (CIEs) was 3.1 per 100 participant-months (range, 0-10.5), and the rate of symptomatic CIEs was 1.7 per 100 participant-months (range, 0-10.5), including 1 case of microbial keratitis (0.04 per 100 participant-months). Rates for CIEs differed substantially among solution groups, with hydrogen peroxide having the lowest rate (0.6 per 100 participant-months; range, 0-0.9). The rate was 0.8 per 100 participant-months (range, 0-8.0) for superior epithelial arcuate lesions, which varied by lens type, 0.04 per 100 participant-months (1 case only) for corneal erosion, and 0.4 per 100 participant-months (range, 0-2.0) for contact lens papillary conjunctivitis, which was modified by type of solution. The rate of solution-induced corneal staining for all lens-solution combinations was 4.7 per 100 participant-months (range, 0-23) and varied significantly based on lens-solution combination (P < .001). CONCLUSIONS The frequency of adverse events varied with silicone hydrogel contact lens and lens solution combinations, with hydrogen peroxide having the lowest incidence of CIEs and solution-induced corneal staining, indicating that lens material and design, type of solution, and solution-lens interactions are likely contributing factors in this mode of lens wear.
Genetic Association between ERCC5 rs17655 Polymorphism and Colorectal Cancer Risk: Evidence Based on a Meta-analysis.

BACKGROUND Previous studies evaluating the association between the excision repair cross complementing group 5 (ERCC5) gene rs17655 polymorphism and colorectal cancer susceptibility generated controversial results. To generate large-scale evidence on whether the ERCC5 rs17655 polymorphism might indeed be associated with colorectal cancer susceptibility, the present meta-analysis was performed. MATERIALS AND METHODS Data were collected from PubMed, Embase and Web of Science, with the last report up to Apr 03, 2015. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association. RESULTS A total of nine studies including 5,102 cases and 6,326 controls based on the search criteria were included and significant associations were found between ERCC5 rs17655 polymorphism CG vs GG overall (OR=1.29, 95% CI=1.18~1.40) and in the dominant model (OR=1.23, 95% CI=1.13~1.33). On subgroup analysis by ethnicity and source of controls, the ERCC5 rs17655 polymorphism was found to correlate with the pathogenesis of colorectal cancer among Asians and Caucasians and with hospital-based populations. CONCLUSIONS This meta-analysis suggests that the ERCC5 rs17655 polymorphism might contribute to genetic susceptibility to colorectal cancer.
Learning effect of computerized cognitive tests in older adults

ABSTRACT Objective: To evaluate the learning effect of computerized cognitive testing in the elderly. Methods: Cross-sectional study with 20 elderly, 10 women and 10 men, with average age of 77.5 (±4.28) years. The volunteers performed two series of computerized cognitive tests in sequence and their results were compared. The applied tests were: Trail Making A and B, Spatial Recognition, Go/No Go, Memory Span, Pattern Recognition Memory and Reverse Span. Results: Based on the comparison of the results, learning effects were observed only in the Trail Making A test (p=0.019). Other tests performed presented no significant performance improvements. There was no correlation between learning effect and age (p=0.337) and education (p=0.362), as well as differences between genders (p=0.465). Conclusion: The computerized cognitive tests repeated immediately afterwards, for elderly, revealed no change in their performance, with the exception of the Trail Making test, demonstrating high clinical applicability, even in short intervals.
Testing Intraday Volatility Spillovers in Turkish Capital Markets: Evidence from Ise

Abstract The aim of this article is to examine the presence of volatility transmission between futures index and underlying stock index by using intraday data in Turkey. We first examined the sudden changes in the variance of futures index return and the underlying spot index return. Then we employed the causality in the variance tests proposed by Hong (2001) and Hafner and Herwartz (2006). According to the empirical results, the spot market was found to be Granger cause of futures market and this result suggests that the spot market plays a more dominant role in the price discovery process in Turkey.
R Package multgee: A Generalized Estimating Equations Solver for Multinomial Responses

The R package multgee implements the local odds ratios generalized estimating equations (GEE) approach proposed by Touloumis, Agresti, and Kateri (2013), a GEE approach for correlated multinomial responses that circumvents theoretical and practical limitations of the GEE method. A main strength of multgee is that it provides GEE routines for both ordinal (ordLORgee) and nominal (nomLORgee) responses, while relevant other softwares in R and SAS are restricted to ordinal responses under a marginal cumulative link model specification. In addition, multgee offers a marginal adjacent categories logit model for ordinal responses and a marginal baseline category logit model for nominal responses. Further, utility functions are available to ease the local odds ratios structure selection (intrinsic.pars) and to perform a Wald type goodness-of-fit test between two nested GEE models (waldts). We demonstrate the application of multgee through a clinical trial with clustered ordinal multinomial responses.
HIV Counseling and Testing of Pregnant Women in Sub‐Saharan Africa: Experiences From a Study on Prevention of Mother‐to‐Child HIV‐1 Transmission in Dar Es Salaam, Tanzania

&NA; The aim of this study was to determine the acceptability of HIV counseling and testing and participation in a mother‐to‐child HIV‐1 transmission intervention study using antiretroviral therapy in Dar es Salaam, Tanzania, one of the sites for the Joint United Nations Program on AIDS (UNAIDS) multicenter Petra trial. HIV testing was offered to all pregnant women who visited three prenatal clinics in Dar es Salaam before 34 weeks' gestation. Group or individual pretest counseling was performed by trained midwives. Laboratory diagnosis of HIV infection was based on two sequential anti‐HIV enzyme‐linked immunosorbent assays. Posttest counseling was given 2 weeks later to women who wished to know their HIV status. HIV testing was offered to a total of 10,010 pregnant women from June 1996 to May 1998, of whom 76.4% (7647 of 10,010) agreed to be tested. The prevalence of HIV‐1 infection was 13.7% (1050 of 7647). Overall, 68.1% (5205 of 7647) returned for their results. Of the HIV‐1‐seropositive respondents, 27.4% (288 of 1050) agreed to participate in the Petra trial after fulfilling the eligibility criteria. Only 16.7% (48 of 288) of the enrolled women disclosed their positive HIV serostatus to their sexual partners. The main reasons for not disclosing the HIV serostatus were fear of stigma and divorce. Sixty percent (29 of 48) of the informed sex partners agreed to be tested for HIV and 69% (20 of 29) tested HIV seropositive. Pregnancy recurrence rate was 4.4 per 100 women years (18 pregnancies during 408 women years of follow‐up) with 10 of 18 (55.6%) women not wanting to carry the pregnancy to term. In conclusion, this information is useful in planning intervention programs for prevention of mother‐to‐child HIV‐1 transmission and it shows that improvements are required in counseling.