Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Nanoclay Partitioning on Microfibril Morphology Development in Polypropylene/Polyamide 6 Nanocomposite Fibers

The aim of the present work was to study the role of organically modified montmorillonite (OMT) partitioning on microfibrillar morphology development of polypropylene (PP)/polyamide 6 (PA6)/organoclay nanocomposite fibers by means of a rheological technique in conjunction with wide angle X-ray diffraction (WAXD) and scanning electron microscopy (SEM). Polypropylene (PP)/polyamide 6 (PA6) blend samples with the same blend ratio (65/35) and nanoorganoclay [Closite 30B (C30B)] content (3%) with and without PP grafted with maleic anhydride (PPgMAH) as a compatibilizer, were considered. All the samples were prepared by melt compounding in an internal mixer using two different methods; a direct method and a PA6 based master batch method. The nanocomposite samples were melt spun by using a single screw extruder equipped with a spinneret. The organoclay WAXD characteristic peak almost disappeared in the PA6/organoclay masterbatch and the master batch based nanocomposite samples, suggesting a highly intercalated and/or exfoliated morphology for these samples. This was evidenced by the melt linear viscoelastic results that showed a low frequency nonterminal storage modulus along with viscosity upturn for the samples prepared by both methods but to a much greater extent for the master batch prepared samples. The presence of compatibilizer was found to have a significant effect on reducing the PA6 particle size evaluated by SEM results for the samples prepared by both methods. Fibers with fibrillar morphology could hardly be produced from all the blend samples at a spinning temperature of 250°C. However, fibers with well-defined fibrils could be obtained from these samples at 190°C. This was explained in terms of the PA6 droplet size and hence the interfacial tension as well as melt strength of PA6 droplets. It was demonstrated that organoclay preferentially located in the PA6 phase in the master batch samples led to larger droplet size which assisted the microfibril formation in these samples compared to samples prepared by the direct method.
Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics

Mice deficient in adipose triglyceride lipase (ATGL−/−) present elevated ectopic lipid levels but are paradoxically glucose-tolerant. Measurement of endogenous glucose production (EGP) and Cori cycle activity provide insights into the maintenance of glycemic control in these animals. These parameters were determined in 7 wild-type (ATGL+/−) and 6 ATGL−/− mice by a primed-infusion of [U-13C6]glucose followed by LC-MS/MS targeted mass-isotopomer analysis of blood glucose. EGP was quantified by isotope dilution of [U-13C6]glucose while Cori cycling was estimated by analysis of glucose triose 13C-isotopomers. Fasting plasma free fatty-acids were significantly lower in ATGL−/− versus control mice (0.43 ± 0.05 mM versus 0.73 ± 0.11 mM, P < 0.05). Six-hour fasting EGP rates were identical for both ATGL−/− and control mice (79 ± 11 versus 71 ± 7 μmol/kg/min, resp.). Peripheral glucose metabolism was dominated by Cori cycling (80 ± 2% and 82 ± 7% of glucose disposal for ATGL−/− and control mice, resp.) indicating that peripheral glucose oxidation was not significantly upregulated in ATGL−/− mice under these conditions. The glucose 13C-isotopomer distributions in both ATGL−/− and control mice were consistent with extensive hepatic pyruvate recycling. This suggests that gluconeogenic outflow from the Krebs cycle was also well compensated in ATGL−/− mice.
Determinants of Alliance Portfolio Complexity and its Effect on Innovative Performance of Companies

Alliance formation is often described as a mechanism used by firms to increase voluntary knowledge transfers. Access to external knowledge has been increasingly recognized as a main source of a firm's innovativeness. In this paper we examine decisions to form alliance portfolios of foreign and domestic partners by three groups of firms: innovators (firms that are successful in introducing new products to the market), imitators (firms that are successful at introducing new products, which are not new to the market) and product non-innovators. We consider an alliance portfolio that includes different partnership types (competitor, customer, supplier, university/research center). We develop a measure of portfolio complexity which we define as the number and diversity of elements of the alliance portfolio with which a firm must interact. We then estimate models that explain portfolio complexity and its impact on firm's innovative performance. Using panel data on more than 1800 firms in the Netherlands we find that foremost innovators have a strong propensity to form portfolios consisting of international alliances. Being an innovator or imitator also increases the propensity to form a portfolio of domestic alliances, relative to non-innovators; but this propensity is not stronger for innovators. Innovators appear to derive benefit from both intensive (exploitative) and broad (explorative) use of external information sources. The former sourcing is more important for innovators, while the latter for imitators. Finally, alliance complexity is found to have an inverse U-shape relationship to innovative performance.
Tuberculosis infection in patients with rheumatoid arthritis and the effect of infliximab therapy.

OBJECTIVE According to the Centers for Disease Control and Prevention, the 1999 and 2000 incidence rates for tuberculosis (TB) in the US population were 6.4 and 5.8, respectively, per 100,000 persons. Recently, reports of TB following infliximab administration have raised questions regarding the rate of TB in patients with rheumatoid arthritis (RA) generally and in those treated with infliximab in clinical practice. We undertook this study to determine the baseline rate of TB in RA prior to the introduction of infliximab and to determine the rate of TB among those currently receiving infliximab. METHODS We surveyed patients with questionnaires, followed by detailed validation from medical records and physician reports. In study 1, we evaluated 10,782 RA patients in 1998-1999 prior to the widespread use of infliximab. In study 2, we evaluated 6,460 infliximab-treated patients in 2000-2002. RESULTS In study 1, the lifetime rate of TB was 696 per 100,000 patients (95% confidence interval [95% CI] 547-872). Of these cases, 76.8% occurred prior to the onset of RA. During the period of prospective followup, 1 case of TB developed during 16,173 patient-years of followup, yielding a rate of 6.2 cases (95% CI 1.6-34.4) per 100,000 patients. In study 2, the TB incidence rate among infliximab-treated patients was 52.5 cases (95% CI 14.3-134.4) per 100,000 patient-years of exposure. Three of the 4 cases occurred in patients with a history of TB exposure, and no cases occurred in persons with recent TB skin tests or prophylaxis. CONCLUSION The rate of TB is not increased in RA patients generally. Among infliximab-treated patients, the rate is 52.5 cases (95% CI 14.3-134.4) per 100,000 patient-years of exposure. A thorough medical history regarding TB, as well as tuberculin testing and radiographic examination (if indicated), should be an essential component of anti-tumor necrosis factor therapy.
Cardiac systolic rotation and contraction before and after valve replacement for aortic stenosis: a myocardial tagging study using MR imaging.

OBJECTIVE Aortic stenosis leads to the derangement of cardiac function and contraction mode because of chronic pressure overload that is relieved after surgical valve replacement. The purpose of this study was to determine the changes in left ventricular systolic rotation and contraction using MR tagging in patients with aortic stenosis before and after surgical valve replacement compared with age-matched healthy volunteers. MATERIALS AND METHODS Twelve patients with aortic stenosis were examined with an electrocardiographically triggered two-dimensional tagging sequence at 1.5 T before and 12 months after surgical valve replacement for the evaluation of wall function of the apical, mid ventricular, and basal levels. Eight healthy volunteers in the same age group served as the control group. RESULTS Before surgery, all patients showed a significant increase of apical rotation (22.2 degrees +/- 5.9 degrees vs 10.3 degrees +/- 2.5 degrees, p < 0.0001) and overall left ventricular torsion (25.1 degrees +/- 6.6 degrees vs 14.5 degrees +/- 3.7 degrees, p < 0.001); basal rotation was not significantly different (-2.9 degrees +/- 2.1 degrees vs -4.2 degrees +/- 1.9 degrees, p = not significant) compared with the volunteer group. Apical rotation and torsion were negatively correlated with left ventricular mass (r = -0.73, p < 0.01, and r = -0.61, p < 0.05, respectively) and end-diastolic volume (r = -0.73, p < 0.01 and r = -0.64, p < 0.03, respectively). One year after surgery, basal rotation was reduced in the patients with aortic stenosis compared with the patients in the control group (-1.9 degrees +/- 1.8 degrees, p < 0.01). In comparison with preoperative values, apical rotation (14.2 degrees +/- 3.6 degrees, p < 0.01) also decreased but was still elevated, and this resulted in a normalization of left ventricular torsion (16.1 degrees +/- 3.7 degrees, p < 0.01). CONCLUSION Surgical valve replacement for aortic stenosis leads to normalization of the left ventricular torsion 1 year after surgery. Pressure overload before surgery is associated with an increase of systolic left ventricular wringing motion, possibly serving as a compensatory mechanism. This mechanism declines with increasing left ventricular hypertrophy and dilatation.
Quantitative Historical Change in Bumblebee (Bombus spp.) Assemblages of Red Clover Fields

Background Flower visiting insects provide a vitally important pollination service for many crops and wild plants. Recent decline of pollinating insects due to anthropogenic modification of habitats and climate, in particular from 1950's onwards, is a major and widespread concern. However, few studies document the extent of declines in species diversity, and no studies have previously quantified local abundance declines. We here make a quantitative assessment of recent historical changes in bumblebee assemblages by comparing contemporary and historical survey data. Methodology/Principal Findings We take advantage of detailed, quantitative historical survey data from the 1930's on bumblebee (Bombus spp.) abundances and species composition in red clover (Trifolium pratense) fields, an important floral resource and an attractant of all bumblebee species. We used the historical survey data as a pre-industrialization baseline, and repeated the same sampling protocol at nearly the same localities at present, hence setting up a historical experiment. We detected historical changes in abundances (bees/m2) of both workers (the “pollinatory units”) and queens (effective population size), in addition to species composition. In particular, long-tongued bumblebee species showed consistent and dramatic declines in species richness and abundances throughout the flowering season of red clover, while short-tongued species were largely unaffected. Of 12 Bombus species observed in the 1930's, five species were not observed at present. The latter were all long-tongued, late-emerging species. Conclusions/Significance Because bumblebees are important pollinators, historical changes in local bumblebee assemblages are expected to severely affect plant reproduction, in particular long-tubed species, which are pollinated by long-tongued bumblebees.
Moving Beyond Self‐Report: Implicit Associations about Death/Life Prospectively Predict Suicidal Behavior among Veterans

Reliance on self-report limits clinicians' ability to accurately predict suicidal behavior. In this study the predictive validity of an objective measure, the death/suicide Implicit Association Test (d/sIAT), was tested among psychiatrically hospitalized veterans. Following acute stabilization, 176 participants completed the d/sIAT and traditional suicide risk assessments. Participants had similar d/sIAT scores regardless of whether they had recently attempted suicide. However, d/sIAT scores significantly predicted suicide attempts during the 6-month follow-up above and beyond other known risk factors for suicidal behavior (OR = 1.89; 95% CI: 1.15-3.12; based on 1SD increase). The d/sIAT may augment the accuracy of suicide risk assessment.
Low-Tech, Pilot Scale Purification of a Recombinant Spider Silk Protein Analog from Tobacco Leaves

Spider dragline is used by many members of the Araneae family not only as a proteinogenic safety thread but also for web construction. Spider dragline has been shown to possess high tensile strength in combination with elastic behavior. This high tensile strength can be attributed to the presence of antiparallel β-sheets within the thread; these antiparallel β-sheets are why the protein is classified as a silk. Due to the properties of spider silk and its technical and medical uses, including its use as a suture material and as a scaffold for tissue regeneration, spider dragline is a focus of the biotechnology industry. The production of sufficient amounts of spider silk is challenging, as it is difficult to produce large quantities of fibers because of the cannibalistic behavior of spiders and their large spatial requirements. In recent years, the heterologous expression of genes coding for spider silk analogs in various hosts, including plants such as Nicotiana tabacum, has been established. We developed a simple and scalable method for the purification of a recombinant spider silk protein elastin-like peptide fusion protein (Q-/K-MaSp1-100× ELP) after heterologous production in tobacco leaves involving heat and acetone precipitation. Further purification was performed using centrifugal Inverse Transition Cycling (cITC). Up to 400 mg of highly pure spider silk protein derivatives can be isolated from six kilograms of tobacco leaves, which is the highest amount of silk protein derivatives purified from plants thus far.
Investigations of fiber twist on the mechanical properties of sisal fiber yarns and their composites

The effect of fiber twist on the tensile properties of single sisal fibers was investigated by single fiber tensile test. Four kinds of sisal yarns with four different levels of twist were made and the mechanical properties were investigated on both unimpregnated and resin-impregnated sisal yarns. A critical fiber twist level for unimpregnated sisal yarns was found beyond which the tensile properties started to decrease with the increasing of the level of fiber twist. However, for resin-impregnated sisal yarns, both tensile strength and modulus decreased with the increasing of the fiber twist level. In addition, the effect of fiber twist on both the tensile and flexural properties of unidirectional sisal yarn reinforced composites was studied. It was shown that lower twist level led to higher mechanical properties of its reinforced composites. Compared with the experimental results, Rao’s model proved to accurately calculate the Young’s modulus of fiber yarns with different levels of twist. Thus, the Young’s modulus of sisal yarn reinforced composites could be predicted by the rule of mixtures hereafter.
Analysis of the Effects of the Bruton's tyrosine kinase (Btk) Inhibitor Ibrutinib on Monocyte Fcγ Receptor (FcγR) Function*

The irreversible Bruton's tyrosine kinase (Btk) inhibitor ibrutinib has shown efficacy against B-cell tumors such as chronic lymphocytic leukemia and B-cell non-Hodgkin lymphoma. Fcγ receptors (FcγR) on immune cells such as macrophages play an important role in tumor-specific antibody-mediated immune responses, but many such responses involve Btk. Here we tested the effects of ibrutinib on FcγR-mediated activities in monocytes. We found that ibrutinib did not affect monocyte FcγR-mediated phagocytosis, even at concentrations higher than those achieved physiologically, but suppressed FcγR-mediated cytokine production. We confirmed these findings in macrophages from Xid mice in which Btk signaling is defective. Because calcium flux is a major event downstream of Btk, we tested whether it was involved in phagocytosis. The results showed that blocking intracellular calcium flux decreased FcγR-mediated cytokine production but not phagocytosis. To verify this, we measured activation of the GTPase Rac, which is responsible for actin polymerization. Results showed that ibrutinib did not inhibit Rac activation, nor did the calcium chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester). We next asked whether the effect of ibrutinib on monocyte FcγR-mediated cytokine production could be rescued by IFNγ priming because NK cells produce IFNγ in response to antibody therapy. Pretreatment of monocytes with IFNγ abrogated the effects of ibrutinib on FcγR-mediated cytokine production, suggesting that IFNγ priming could overcome this Btk inhibition. Furthermore, in monocyte-natural killer cell co-cultures, ibrutinib did not inhibit FcγR-mediated cytokine production despite doing so in single cultures. These results suggest that combining ibrutinib with monoclonal antibody therapy could enhance chronic lymphocytic leukemia cell killing without affecting macrophage effector function.
X-ray diffraction computed tomography: a survey and description

Coherently scattered x-rays are mainly confined to a forward peaked cone, which exhibits, due to their coherence, structural information of the atomic arrangement in the sample. Coherent scattering in amorphous materials, which are of random short range order, therefore results in board diffraction ring patter, whereas crystalline substance show more confined diffraction rings or even Brag spots. X-ray diffraction computed tomography (XRDCT) reconstructs the intensities diffracted from extended objects on a square image grid and thus retrieves the local structure. A short survey is presented about what information can be extracted from diffraction experiments. Hereby a new method is proposed to use the Rietveld refinement for quantitative XRDCT. Also the possible use of XRDCT to reconstruct the spatial distribution of preferred orientation axis is suggested. An imaging system for XRDCT, consisting of a medical image intensifier tube and CCD readout system, is presented, which includes a modified beam stop for recording the intensity of the transmitted beam. Depending on the application this imaging system cam work in first generation or second generation tomography mode. Furthermore a new approach for the reconstruction of the differential coherent cross-section is proposed. It includes an absorption correction based on weighted sinograms. The introduced reconstruction strategy is elucidated by experimental result from a simple phantom. The measured data also validate the simulation program, written to study more complex phantoms under different experimental conditions. Finally possible applications in medical and material science are discussed. A design for a mammography setup using x-ray diffraction is presented.
Gromov invariants for holomorphic maps from Riemann surfaces to Grassmannians

Two compactifications of the space of holomorphic maps of fixed degree from a compact Riemann surface to a Grassmannian are studied. It is shown that the Uhlenbeck compactification has the structure of a projective variety and is dominated by the algebraic compactification coming from the Grothendieck Quot Scheme. The latter may be embedded into the moduli space of solutions to a generalized version of the vortex equations studied by Bradlow. This gives an effective way of computing certain intersection numbers (known as “Gromov invariants”) on the space of holomorphic maps into Grassmannians. We carry out these computations in the case where the Riemann surface has genus one. Department of Mathematics, University of Utah, Salt Lake City, Utah 84112 E-mail address: bertram@math.utah. edu Department of Mathematics, Brown University, Providence, Rhode Island 02912 E-mail address: daskal@gauss.math.brown.edu Department of Mathematics, University of California, Irvine, California 92717 E-mail address: raw@math.uci. edu License or copyright restrictions may apply to redistribution; see http://www.ams. org/journal-terms-of-use
On Finding the Largest Mean Among Many

Sampling from distributions to find the one with the largest mean arises in a broad range of applications, and it can be mathematically modeled as a multi-armed bandit problem in which each distribution is associated with an arm. This paper studies the sample complexity of identifying the best arm (largest mean) in a multi-armed bandit problem. Motivated by large-scale applications, we are especially interested in identifying situations where the total number of samples that are necessary and sufficient to find the best arm scale linearly with the number of arms. We present a single-parameter multi-armed bandit model that spans the range from linear to superlinear sample complexity. We also give a new algorithm for best arm identification, called PRISM, with linear sample complexity for a wide range of mean distributions. The algorithm, like most exploration procedures for multi-armed bandits, is adaptive in the sense that the next arms to sample are selected based on previous samples. We compare the sample complexity of adaptive procedures with simpler non-adaptive procedures using new lower bounds. For many problem instances, the increased sample complexity required by non-adaptive procedures is a polynomial factor of the number of arms.
Two new acylgluconic acids from the nearly ripe fruits of Evodia rutaecarpa

Two new acylgluconic acids, trans-feruloylgluconic acid (1) and trans-caffeoylgluconic acid (2), together with three known compounds, myo-inositol (3), phthalic acid dibutyl ester (4), and wuzhuyuamide-I (5), were isolated from the water soluble part of the dried nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth. Their structures were determined by spectroscopic methods, including IR, UV, ESITOFMS, HRSIMS, 1D and 2D NMR spectral analyses.