Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic Release and Clearance of Circulating Microparticles During Cardiac Stress

Rationale: Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease. Objective: To investigate microparticle release during cardiac stress and how this response differs in those with vascular disease. Methods and Results: We measured a comprehensive panel of circulating cell-derived microparticles by a standardized flow cytometric protocol in 119 patients referred for stress echocardiography. Procoagulant, platelet, erythrocyte, and endothelial but not leukocyte, granulocyte, or monocyte-derived microparticles were elevated immediately after a standardized dobutamine stress echocardiogram and decreased after 1 hour. Twenty-five patients developed stress-induced wall motion abnormalities suggestive of myocardial ischemia. They had similar baseline microparticle levels to those who did not develop ischemia, but, interestingly, their microparticle levels did not change during stress. Furthermore, no stress-induced increase was observed in those without inducible ischemia but with a history of vascular disease. Fourteen patients subsequently underwent coronary angiography. A microparticle rise during stress echocardiography had occurred only in those with normal coronary arteries. Conclusions: Procoagulant, platelet, erythrocyte, and endothelial microparticles are released during cardiac stress and then clear from the circulation during the next hour. This stress-induced rise seems to be a normal physiological response that is diminished in those with vascular disease.
THE IMPACT OF PERCEPTIONS OF INTERACTIVITY ON CUSTOMER TRUST AND TRANSACTION INTENTIONS IN MOBILE COMMERCE

The interest in the concept of “interactivity” has increased as we are entering an “always-on” society where people can interact anytime and anywhere. Despite the importance of interactivity in Mobile Commerce (MC) environment, this topic has been given little attention in the academic literature. This paper identified the components of interactivity and investigated the impact of perceptions of interactivity on customer trust and transaction intentions in MC. Empirical results indicate that the addition of MC-specific components of interactivity (perceived ubiquitous connectivity and perceived contextual offer) improves the model fit. Also the perceptions of user control, responsiveness, connectedness, ubiquitous connectivity, and contextual offer have a significant effect on customer trust in MC. Especially, ubiquitous connectivity and contextual offer have a direct positive effect on transaction intentions in MC. Based on these empirical results, this paper suggests managerial implications of new marketing strategies, focusing on the contextual marketing communication that link online, mobile, and offline environment.
A Comparison of L2–L2 and L2–Heritage Learner Interactions in Spanish Language Classrooms

Conversational interaction studies have typically focused either on second language (L2) learners participating in native speaker-nonnative speaker (NS-NNS) dyads or in NNS-NNS dyads. This study analyzes the task-based interactions of 26 naturally occurring learner dyads in an intermediate-level, university Spanish language classroom, 13 of which were matched L2 learner dyads and 13 of which were mixed L2 learner-heritage learner (HL) dyads. Specifically, the study compared the two dyad types to determine whether they differed in their focus on form or in the amount of talk produced during interaction. Results revealed that the two types of dyads were largely similar, although instances of focus on form were more likely to be resolved in a target-like way by mixed L2-HL pairs than by matched L2-L2 pairs, and there was significantly more target language talk in mixed pairs. Interestingly, L2 learners used the target language significantly more with HL learners than they did with other L2 learners, suggesting that different conversational norms may be at play in the two pair types. Furthermore, posttask questionnaire data indicated that L2 and HL learners alike saw the interaction as a greater opportunity for the L2 learner's development than for the HL learner's, calling into question whether classroom contexts like this one meet the needs of HL learners. [ABSTRACT FROM AUTHOR]
On the capacity of multiple unicast sessions in undirected graphs

Li and Li conjectured that in an undirected network with multiple unicast sessions, network coding does not lead to any coding gain. Surprisingly enough, this conjecture could not so far be verified even for the simple network consisting of K3,2 with four source-sink pairs. Using entropy calculus, we provide the first verification of the Li-Li conjecture for this network. We extend our bound to the case of an arbitrary directed bipartite network
Laser Ablation for Small Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and is increasingly detected at small size (<5 cm) owing to surveillance programmes in high-risk patients. For these cases, curative therapies such as resection, liver transplantation, or percutaneous ablation have been proposed. When surgical options are precluded, image-guided tumor ablation is recommended as the most appropriate therapeutic choice in terms of tumor local control, safety, and improvement in survival. Laser ablation (LA) represents one of currently available loco-ablative techniques: light is delivered via flexible quartz fibers of diameter from 300 to 600 μm inserted into tumor lesion through either fine needles (21g Chiba needles) or large-bore catheters. The thermal destruction of tissue is achieved through conversion of absorbed light (usually infrared) into heat. A range of different imaging modalities have been used to guide percutaneous laser ablation, but ultrasound and magnetic resonance imaging are most widely employed, according to local experience and resource availability. Available clinical data suggest that LA is highly effective in terms of tumoricidal capability with an excellent safety profile; the best results in terms of long-term survival are obtained in early HCC so that LA can be proposed not only in unresectable cases but, not differently from radiofrequency ablation, also as the first-line treatment.
Spatial structure and the effects of host and soil environments on communities of ectomycorrhizal fungi in wooded savannas and rain forests of Continental Africa and Madagascar

Mycorrhizal fungi play a key role in mineral nutrition of terrestrial plants, but the factors affecting natural distribution, diversity and community composition of particularly tropical fungi remain poorly understood. This study addresses shifts in community structure and species frequency of ectomycorrhizal (EcM) fungi in relation to host taxa, soil depth and spatial structure in four contrasting African ecosystems. We used the rDNA and plastid trnL intron sequence analysis for identification of fungi and host plants, respectively. By partitioning out spatial autocorrelation in plant and fungal distribution, we suggest that African EcM fungal communities are little structured by soil horizon and host at the plant species and family levels. These findings contrast with patterns of vegetation in these forests and EcM fungal communities in other tropical and temperate ecosystems. The low level of host preference indirectly supports an earlier hypothesis that pioneer Phyllanthaceae may facilitate the establishment of late successional Fabaceae and potentially other EcM host trees by providing compatible fungal inoculum in deforested and naturally disturbed ecosystems of tropical Africa.
Noncovalent Association with Stress Protein Facilitates Cross-Priming of CD8+ T Cells to Tumor Cell Antigens by Dendritic Cells1

A viral oncogene carrying well-defined Kb/Db-restricted epitopes was expressed in a heat shock protein (hsp)-associated or nonassociated form in the murine tumor cells P815 and Meth-A. Wild-type SV40 large T-Ag (wtT-Ag) is expressed without stable hsp association; mutant (cytoplasmic cT-Ag) or chimeric (cT272-green fluorescent fusion protein) T-Ag is expressed in stable association with the constitutively expressed, cytosolic hsp73 (hsc70) protein. In vitro, remnants from apoptotic wtT-Ag- or cT-Ag-expressing tumor cells are taken up and processed by immature dendritic cells (DC), and the Kb/Db-binding epitopes T1, T2/3, and T4 of the T-Ag are cross-presented to CTL in a TAP-independent way. DC pulsed with remnants of transfected, apoptotic tumor cells cross-presented the three T-Ag epitopes more efficiently when they processed ATP-sensitive hsp73/cT-Ag complexes than when they processed hsp-nonassociated (native) T-Ag. In vivo, more IFN-γ-producing CD8+ T cells were elicited by a DNA vaccine that encoded hsp73-binding mutant T-Ag than by a DNA vaccine that encoded native, non-hsp-binding T-Ag. Three- to 5-fold higher numbers of T-Ag (T1-, T2/3-, or T4-) specific, Db/Kb-restricted IFN-γ-producing CD8+ T cells were primed during the growth of transfected H-2d Meth-A/cT tumors than during the growth of transfected Meth-A/T tumors in F1(b × d) hosts. Hence, the association of an oncogene with constitutively expressed, cytosolic hsp73 facilitates cross-priming in vitro and in vivo of CTL by DC that process material from apoptotic cells.
Skin color change in Caucasian postmenopausal women predicts summer-winter change in 25-hydroxyvitamin D: findings from the ANSAViD cohort study.

CONTEXT UV radiation is responsible for vitamin D synthesis and skin tanning. Longitudinal data relating skin color to vitamin D status are lacking. OBJECTIVE Our objective was to determine whether seasonal facial skin color changes are related to changes in 25-hydroxyvitamin D [25(OH)D]. DESIGN AND SETTING We conducted a prospective observational cohort study (Aberdeen Nutrition Sunlight and Vitamin D) with five visits over 15 months, starting spring 2006 with an additional visit in spring 2008 at a university medical research center in Scotland, 57° N. PARTICIPANTS Participants included 314 Caucasian postmenopausal women, age 60-65 yr. MAIN OUTCOME MEASURES Facial skin color was assessed by skin reflectance and expressed as the individual typology angle (ITA) (higher number indicates paler skin). 25(OH)D was measured by immunoassay. RESULTS Most women (43%) reported Fitzpatrick skin type III (always burns, always tans), 32% type II, and 25% type I (always burns, never tans). Overall, mean (sd) ITA in degrees were 36.6 (7.7), 38.2 (6.5), and 42.8 (5.3), respectively, for summer, autumn, and winter (P < 0.001). Linear regression showed that a 5° summer-winter change in ITA, was associated with a 15 nmol/liter change in 25(OH)D (P < 0.001) but did not predict winter 25(OH)D. Reported sunscreen use was associated with higher 25(OH)D. Mean (SD) 25(OH)D (nanomoles per liter) but not skin color was lower for the top body mass index quartile (Q4) compared with the other quartiles (summer: Q1, 57.1(19.9); Q4, 49.7 (20.4); P = 0.010). CONCLUSIONS Skin color change between summer and winter predicts seasonal 25(OH)D change. Low vitamin D status in obese women was not due to reduced sun exposure, suggesting that increased requirements or inaccessibility of vitamin D stores may be responsible.
Exploring the impact of trust on research scientists' work engagement: Evidence from Irish science research centres

Purpose – The purpose of this paper is to explore the effects of trust in top management and trust in team members on research scientists' work engagement. Specifically, it is proposed that the link between trust in top management and work engagement will be mediated by organizational identification whereas the relationship between trust in team members and work engagement will be mediated by team psychological safety.Design/methodology/approach – Survey data were collected from 170 research scientists, drawn from six Irish science research centres. Structural equation modelling was used to test the direct and mediating effects.Findings – Results revealed that as hypothesised, organizational identification and team psychological safety fully mediated the effects of trust in top management and trust in team members on work engagement respectively.Research limitations/implications – The cross‐sectional research design and the use of self‐reported data are the main limitations of this research. Additionally,.
Mathematics Beliefs and Achievement of Elementary School Students in Japan and the United States: Results From the Third International Mathematics and Science Study

Student self-beliefs are significantly related to several types of academic achievement. In addition, results from international assessments have indicated that students in Japan have typically scored above international averages (D. L. Kelly, I. V. S. Mullis, & M. O. Martin, 2000). In this study, the author examined relationships between mathematics beliefs and achievement of elementary school-aged students in the United States and Japan. The students had participated in the Third International Mathematics and Science Study (TIMSS; A. E. Beaton et al., 1996). The author examined several self-beliefs and used variance estimation techniques for complex sampling designs. The author identified a number of significant relationships between self-beliefs and mathematics achievement. Students who attributed success in mathematics to controllable factors (e.g., hard work, studying at home) showed higher test scores whereas students who attributed success in mathematics at school to external factors (e.g., good luck) tended to earn lower mathematics test scores. These results extend the findings of previous research results because the author examined large national samples of students in cross-cultural settings as part of a comprehensive international assessment.
Evidence That Very Small Embryonic‐Like Stem Cells Are Mobilized into Peripheral Blood

Recently, we identified in murine adult tissues, including bone marrow, a population of very small embryonic‐like (VSEL) stem cells. Here, we provide further evidence that under steady‐state conditions these cells circulate at very low levels in peripheral blood (PB) (∼100–200 cells/ml) and could be additionally mobilized during pharmacological granulocyte‐colony‐stimulating factor‐induced or stress‐related mobilization, as demonstrated in a model of toxic liver or skeletal muscle damage induced by injection of carbon tetrachloride or cardiotoxin, respectively. The number of circulating VSEL stem cells under steady‐state conditions in PB of 2‐month‐old animals was five times higher than that in 1‐year‐old mice. In conclusion, this study supports a hypothesis that VSEL stem cells are a mobile pool of primitive stem cells that could be released from the stem cell niches into PB. Further studies are needed, however, to see whether the level of these cells circulating in PB could become a prognostic indicator to assess the regenerative potential of an adult organism and/or clinical outcome from an injury.
Wholegrain oat-based cereals have prebiotic potential and low glycaemic index

Population studies show a positive association between increased dietary intake of wholegrains and reduced risk of cardiometabolic disorders. Consumption of wholegrain food has been associated with lower blood glucose and therefore may contribute to a low-glycaemic load diet. The ability to mediate a prebiotic modulation of gut microbiota has recently been suggested to have an inverse correlation with risk of cardiometabolic disease. To date very little work has been carried out on the functionality of wholegrain breakfast cereals in terms of glycaemic response or impact on gut microbiota. An investigation into identifying wholegrain-based breakfast cereals demonstrating both low glycaemic index (GI) and prebiotic attributes was performed. After in vitro digestion, cereal samples were supplemented to pH-controlled anaerobic batch cultures of the human faecal microbiota. Total bacteria populations increased significantly (P < 0·05) in all treated cultures, and the fermentation of a wholegrain oat cluster cereal was associated with proliferation of the Bifidobacterium genus (P = 0·02). Smaller, but significant increases in the Bifidobacterium genus were observed for a further four oat-based cereals. Significant increases in the Lactobacillus–Enterococcus group were observed for granola (P = 0·01), 100 % wholegrain aggregate (P = 0·04) and 70 % wholegrain loops (P = 0·01). Cereals demonstrating prebiotic potential were selected for GI determination in twelve healthy subjects. The wholegrain oat aggregate cereal achieved the lowest GI value (40), three other cereals ranged between 44 and 74, with instant porridge resulting in a GI value similar to the standard glucose control. The present study suggests that wholegrain oat-based breakfast cereals may be prebiotics and have the potential to have low GI.
Soybean Root Development Relative to Vegetative and Reproductive Phenology

Knowledge of soybean [Glycine max (L.) Merr. ] primary, secondary, and tertiary root tip locations in the soil vs. seasonal time would enhance modeling of soybean development. The seasonal progression of root tip development and shoot phenology was evaluated in situ using an imaging device inserted into minirhizotron tubes installed in the soil at an in-row 30° angle. Primary root tip extension was linear (i.e., 1.5 and 1.2 cm d⁻¹ each year) until the full-seed stage. Emergent 5-mm secondary roots were routinely detected about 10-cm above the primary root tip, and thus present in a soil layer 11 d after the primary root tip had passed through that layer. Secondary roots followed a similar temporal pattern. Primary root tip location in the soil paralleled a 17°C soil temperature isoline. The 3.7-d phyllochron of main-stem node accrual between first node and seed fill may be a calibratable proxy for inferring correspondent root tip depths.
The molecular adsorbents recycling system as a liver support system based on albumin dialysis: a summary of preclinical investigations, prospective, randomized, controlled clinical trial, and clinical experience from 19 centers.

Artificial liver support aims to prolong survival time of patients with liver failure by detoxification. Albumin as a molecular adsorbent in dialysis solution is capable of attracting even tightly albumin-bound toxins from blood into the dialysate if a specific dialysis membrane is used and if the albumin's binding sites are on-line-purified by a sorbent/dialysis-based recycling system (i.e., molecular adsorbents recycling system, or MARS). The MARS technology has been shown to remove water-soluble and albumin-bound toxins and to provide renal support in case of renal failure. Fourteen centers have reported that MARS treatment improved mental status of patients with liver failure and hepatic encephalopathy. In treating liver failure and cholestasis, MARS was associated with hemodynamic stabilization, improvement of hepatic and kidney function, and disappearance of pruritus. In hepatic failure and hepatorenal syndrome, a prospective, randomized, controlled trial of MARS treatment was able to prolong survival time significantly. MARS has been used in 26 patients with acute liver failure or primary graft dysfunction. Nineteen centers reporting on 103 patients have shown that MARS treatment is safe, easy to handle, feasible, and effective.
Using genetic diversity information to establish core collections of Stylosanthes capitata and Stylosanthes macrocephala

Stylosanthes species are important forage legumes in tropical and subtropical areas. S. macrocephala and S. capitata germplasm collections that consist of 134 and 192 accessions, respectively, are maintained at the Brazilian Agricultural Research Corporation Cerrados (Embrapa-Cerrados). Polymorphic microsatellite markers were used to assess genetic diversity and population structure with the aim to assemble a core collection. The mean values of HO and HE for S. macrocephala were 0.08 and 0.36, respectively, whereas the means for S. capitata were 0.48 and 0.50, respectively. Roger’s genetic distance varied from 0 to 0.83 for S. macrocephala and from 0 to 0.85 for S. capitata. Analysis with STRUCTURE software distinguished five groups among the S. macrocephala accessions and four groups among those of S. capitata. Nei’s genetic diversity was 27% in S. macrocephala and 11% in S. capitata. Core collections were assembled for both species. For S. macrocephala, all of the allelic diversity was represented by 23 accessions, whereas only 13 accessions were necessary to represent all allelic diversity for S. capitata. The data presented herein evidence the population structure present in the Embrapa-Cerrados germplasm collections of S. macrocephala and S. capitata, which may be useful for breeding programs and germplasm conservation.
One-year effect of a nurse-led psychosocial intervention on depressive symptoms in patients with head and neck cancer: a randomized controlled trial.

BACKGROUND Many patients with head and neck cancer (HNC) experience depressive symptoms after treatment. This randomized controlled trial investigated the effects of a psychosocial nurse counseling and after intervention (NUCAI) versus usual care on the depressive and HNC-related physical symptoms of patients with HNC at 1 year after diagnosis. METHODS A total of 205 patients with HNC were randomly assigned to either intervention (n = 103) or usual care (n = 102), with stratification for gender and tumor stage. The NUCAI, which consisted of six bimonthly 45-minute counseling sessions, was a problem-focused intervention aimed at helping patients to manage the physical, psychological, and social consequences of HNC and its treatment. It was nurse-led and offered in combination with regular medical follow-up visits at the University Medical Center Utrecht, the Netherlands. Depressive symptoms at 1 year after diagnosis were the primary outcome. Analyses were performed on an intention-to-treat basis for the total sample and for a predefined subgroup of patients with raised levels of depressive symptoms (Center for Epidemiologic Studies-Depression score ≥ 12; n = 91) at baseline using mixed-effect models. RESULTS One year after HNC treatment, levels of depressive symptoms were significantly lower in the intervention group than in the control group in the total sample and in the subgroup of patients with raised levels of depressive symptoms. CONCLUSION The NUCAI was feasible and effective in reducing depressive symptoms in patients with HNC 1 year after HNC treatment, and especially in patients with raised levels of depressive symptoms. The results of this study need to be confirmed in future studies before the NUCAI can be used in daily clinical practice.
Shareholder Oversight and the Regulatory Environment #

During a period where Japanese banks operated under a less restrictive regulatory environment, 1986-88, we find positive relationships between bank risk and ownership concentration. This empirical evidence reveals shareholder activism by the largest shareholders. During the periods immediately before and immediately after this particular subperiod, which are characterized by stricter regulatory environments, we do no not observe evidence of shareholder activism. Taken together, these results are consistent with the argument that restrictive regulation and shareholder oversight are substitutes for one another. Time-series results and bank performance results yield consistent evidence.