Miracle-dz/UniFAR-FTUs huggingface dataset:
Ethyl pyruvate

Purpose of review Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate was shown to ameliorate some of the structural and functional changes associated with mesenteric ischemia and reperfusion in rats. Recent findings Treatment with ethyl pyruvate has been shown to improve survival and ameliorate organ dysfunction in a wide variety of preclinical models of critical illnesses, such as severe sepsis, acute respiratory distress syndrome, burn injury, acute pancreatitis and stroke. Ethyl pyruvate has been shown to improve cardiac function after coronary ischemia and reperfusion. This ester was originally regarded as a way to administer pyruvate, while avoiding some of the problems associated with the instability of pyruvate in aqueous solutions. Increasingly, however, it is becoming apparent that certain pyruvate esters, including ethyl pyruvate, have pharmacological effects, such as suppression of inflammation, which are distinct from those exerted by pyruvate anion. Ethyl pyruvate has been tested in human volunteers and shown to be safe at clinically relevant doses. Summary Ethyl pyruvate is a simple molecule that has been shown to have salutary effects in numerous large and small animal models of critical illness. It remains to be determined whether this ester can be used successfully to treat human diseases.
Kelp and dolphin gulls cause perineal wounds in South American fur seal pups (Arctocephalus australis) at Guafo Island, Chilean Patagonia

During five reproductive seasons, we documented the presence, extent and origin of perineal wounds in South American fur seal pups (Arctocephalus australis) on Guafo Island, Northern Chilean Patagonia. The seasonal prevalence of perineal wounds ranged from 5 to 9%, and new cases were more common at the end of the breeding season (February), when pups were on average two months old and were actively expelling hookworms (Uncinaria sp). Histologically, wounds corresponded to marked ulcerative lymphoplasmacytic and histiocytic dermatitis with granulation tissue and mixed bacterial colonies. In 2015 and 2017, kelp gulls (Larus dominicanus) and dolphin gulls (Leucophaeus scoresbii) were observed picking and wounding the perineal area of marked pups. This behaviour occurred more frequently after the pups' defecation, when sea gulls engaged in consumption of pups' faeces. The affected pups usually had moderate to marked hookworm infections along with bloody diarrhoea and anaemia. Pups with severe wounds (23% of affected animals) had swollen perineal areas and signs of secondary systemic bacterial infection. We propose that seagulls on Guafo Island have learned to consume remains of blood and parasites in the faeces of pups affected by hookworm infection, causing perineal wounds during this process. We conclude that this perineal wounding is an unintentional, occasional negative effect of an otherwise commensal gull–fur seal relationship.
Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma

Disruption of the retinoblastoma (RB) tumor suppressor pathway, either through genetic mutation of upstream regulatory components or mutation of RB1 itself, is believed to be a required event in cancer. However, genetic alterations in the RB-regulated E2F family of transcription factors are infrequent, casting doubt on a direct role for E2Fs in driving cancer. In this work, a mutation analysis of human cancer revealed subtle but impactful copy number gains in E2F1 and E2F3 in hepatocellular carcinoma (HCC). Using a series of loss- and gain-of-function alleles to dial E2F transcriptional output, we have shown that copy number gains in E2f1 or E2f3b resulted in dosage-dependent spontaneous HCC in mice without the involvement of additional organs. Conversely, germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against HCC. Combinatorial mapping of chromatin occupancy and transcriptome profiling identified an E2F1- and E2F3B-driven transcriptional program that was associated with development and progression of HCC. These findings demonstrate a direct and cell-autonomous role for E2F activators in human cancer.
The Effect of Nitric Oxide Synthase Inhibitors on the Development of Analgesic Tolerance to Dipyrone in Mice

Recent investigations have shown that, similarly to opioids, tolerance develops to the analgesic effects of nonsteroidal anti-inflammatory drugs (NSAIDs). Nitric oxide has been shown to play an important role in opioid-induced analgesic tolerance; we, therefore, planned to determine if nitric oxide also plays role in the analgesic tolerance to dipyrone, a NSAID. Using the hot-plate test in mice, an analgesic tolerance developed to dipyrone with its 150 and 300 mg/kg intraperitoneal doses after 7 days; no tolerance was observed with its dose of 600 mg/kg. Neither 7-nitroindazole (50 mg/kg, i.p.), a neuronal NOS inhibitor, nor aminoguanidine (30 mg/kg, i.p.), an inducible NOS inhibitor, had any effect on dipyrone-induced analgesic tolerance with doses, which also had no analgesic effect when used alone. Our results show that nitric oxide does not play role in the analgesic tolerance to dipyrone; however, further experiments are required to delineate the mechanisms and to take preventive measures against this problem, which will possibly limit the use of NSAIDs.
Low temperature infrared spectroscopy study of pyrazinamide: from the isolated monomer to the stable low temperature crystalline phase.

A structural and spectroscopic analysis of the anti-tuberculosis drug pyrazinamide (PZA) was carried out. The PZA molecule was predicted theoretically to possess two conformers differing by internal rotation around the C-C( horizontal lineO) bond, with the E conformer (C(s) symmetry point group; N-C-C horizontal lineO dihedral: 180 degrees ) being ca. 30 kJ mol(-1) more stable than the Z form (C(1) point group; N-C-C horizontal lineO dihedral: ca. +/- 42 degrees ). In consonance with both the large energy difference and low energy barrier between the Z and E conformers, upon isolation in low temperature argon and xenon matrices, only the E form could be observed and characterized spectroscopically. In the argon matrix, this conformer was found to exist in at least three matrix sites, of different stability. In a supersonic jet, besides the monomer (E), the most stable dimer of PZA with two equivalent NH.O horizontal line hydrogen bonds could also be identified. Its spectrum reveals rapid energy flow out of the excited NH stretching mode mediated by one of the heteroatoms in the ring. Finally, the IR spectra of the amorphous solid resulting from fast cooling of the vapor of the compound (initially in the alpha crystalline phase) onto the cold substrate of the cryostat (10 K) and of the crystalline phase resulting from warming the amorphous solid were also recorded and interpreted. The obtained crystalline phase was found to be the thermodynamically most stable delta polymorph of PZA.
Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation

SET domain-containing proteins play a vital role in regulating gene expression during development through modifications in chromatin structure. Here we show that SET domain-containing 5 (Setd5) is divergently transcribed with Gt(ROSA26)Sor, is necessary for mammalian development, and interacts with the PAF1 co-transcriptional complex and other proteins. Setd5-deficient mouse embryos exhibit severe defects in neural tube formation, somitogenesis and cardiac development, have aberrant vasculogenesis in embryos, yolk sacs and placentas, and die between embryonic day 10.5 and 11.5. Setd5-deficient embryonic stem cells have impaired cellular proliferation, increased apoptosis, defective cell cycle progression, a diminished ability to differentiate into cardiomyocytes and greatly perturbed gene expression. SETD5 co-immunoprecipitates with multiple components of the PAF1 and histone deacetylase-containing NCoR complexes and is not solely required for major histone lysine methylation marks. In the absence of Setd5, histone acetylation is increased at transcription start sites and near downstream regions. These findings suggest that SETD5 functions in a manner similar to yeast Set3p and Drosophila UpSET, and that it is essential for regulating histone acetylation during gene transcription. Highlighted article: Mouse Setd5 mutants are embryonic lethal with strong cardiovascular phenotypes. Setd5 interacts with PAF1C and NCoR complexes to regulate co-transcriptional chromatin modifications.
Microstructure and mechanical properties of Ti–6Al–4V manufactured by electron beam melting process

Abstract Electron beam melting (EBM) is a powder based additive manufacturing technology used to produce parts with high geometrical complexity directly from a three-dimensional computer aided design model. It is one of the most promising methods of additive manufacturing for a wide range of industrial applications, especially the medical implant and aerospace industries. This paper presents the microstructures and mechanical behaviour of as fabricated and hot isostatic pressing (HIP) processed parts, which are made by an Arcam A1 EBM system. The biocompatible titanium alloy Ti6Al4V was used as the material for the specimens. Characterisation of the parts after manufacturing and after tensile and fatigue tests was conducted by scanning electron microscopy. The mechanical properties, including tensile stress–strain, Vickers microhardness (HV), surface roughness and fatigue cycles, have been measured and compared with similar literature relevant to EBM made Ti6Al4V parts. The results highlight the advantage and disadvantage of HIP processing on the mechanical properties and microstructure of the EBM made parts.
A Perspective on Databases and Data Mining

We discuss the use of database methods for data mining. Recently impressive results have been achieved for some data mining problems using highly specialized and clever data structures. We study how well one can manage by using general purpose database management systems. We illustrate our ideas by investigating the use of a dbms for a well-researched area: the discovery of association rules. We present a simple algorithm, consisting of only union and intersection operations, and show that it achieves quite good performance on an efficient dbms. Our method can incorporate inheritance hierarchies to the association rule algorithm easily. We also present a technique that effectively reduces the number of database operations when searching large search spaces that contain only few interesting items. Our work shows that database techniques are promising for data mining: general architectures can achieve reasonable results.
The control of herbage intake in the grazing ruminant

effects of variations in the nutrient content and internal structure of plant tissues on the voluntary intake of forages by ruminants explained in terms of conventional theories of metabolic and physical controls to appetite they do not non-nutritional characteristics of on herbage grazing to examine the possible interactions between physical and behavioural controls under the mechanisms involved consider the interrelations the components behaviour and on herbage relations between the structural characteristics of canopy and grazing face of limiting conditions, its in order to offset the effects of of
Socioeconomic status, psychological distress, and other maternal risk factors for fetal alcohol spectrum disorders among American Indians of the Northern Plains

The relationship of selected demographic, socioeconomic status (SES), and psychological characteristics was examined in interviews with 176 Northern Plains American Indian mothers whose children were referred to diagnostic clinics for evaluation of developmental disabilities, including fetal alcohol spectrum disorders (FASD). Thirty-nine mothers had children diagnosed with an FASD (Group 1), 107 had children who were not diagnosed with an FASD or other major disability (Group 2), and 30 additional mothers with normally performing children, matched by age, sex, and reservation with those diagnosed with an FASD, were recruited as a comparison group (Group 3). Analysis revealed statistically signifi cant differences (p < .001) in alcohol consumption among all three groups, and a statistically signifi cant difference in the mean Total Distress score among the three groups of mothers, F(2, 176) = 9.60, p < . 001, with Group 3 having a lower mean score than Groups 1 and 2. Sequential regression analysis revealed that the quantity of alcohol consumed prior to knowledge of pregnancy, when combined with SES and Total Distress, was more highly associated with having a child diagnosed with an FASD (R2 = .206) than was quantity of alcohol consumed alone.
An Efficient and Balanced Platform for Data-Parallel Subsampling Workloads

With the advent of internet services, data started growing faster than it can be processed. To personalize user experience, this enormous data has to be processed in real time, in interactive fashion. In order to achieve faster data processing often a statistical method called subsampling. Subsampling workloads compute statistics from a random subset of sample data (i.e., a subsample). Data-parallel platforms group these samples into tasks; each task subsamples its data in parallel. Current, state-of-the-art platforms such as Hadoop are built for large tasks that run for long periods of time, but applications with smaller average task sizes suffer large overheads on these platforms. Tasks in subsampling workloads are sized to minimize the number of overall cache misses, and these tasks can complete in seconds. This technique can reduce the overall length of a map-reduce job, but only when the savings from the cache miss rate reduction are not eclipsed by the platform overhead of task creation and data distribution. In this thesis, we propose a data-parallel platform with an efficient data distribution component that breaks data-parallel subsampling workloads into compute clusters with tiny tasks. Each tiny task completes in few hundreds of milliseconds to seconds. Tiny tasks reduce processor cache misses caused by random subsampling, which speeds up per-task running time. However, they cause significant scheduling overheads and data distribution challenges. We propose a task knee-pointing algorithm and a dynamic scheduler that schedules the tasks to worker nodes based on the availability and response times of the data nodes. We compare our framework against various configurations of BashReduce and Hadoop. A detailed discussion of tiny task approach on two workloads, EAGLET and Netflix movie rating is presented.
A histologic and histomorphometric evaluation of anorganic bovine bone retrieved 9 years after a sinus augmentation procedure.

BACKGROUND Anorganic bovine bone (ABB) has been shown to have osteoconductive properties and no inflammatory or adverse responses as grafting materials used in sinus augmentation procedures. Despite these successful results, histologic data in humans over the long-term period are scarce. The purpose of this study was to analyze the histomorphometric data 9 years after surgery in a case of maxillary sinus augmentation using ABB. METHODS The histologic evaluation was performed in five different thin sections of the specimen, comparing histomorphometric measures for newly formed bone, marrow spaces, biomaterial particles remnants, and number of osteocytes embedded in both trabecular bone and bone tissue near the ABB. The investigation was carried out by means of scanning electron microscopy and brightfield and circularly polarized light microscopy. RESULTS We observed a mean amount of newly formed bone of 46.0% +/- 4.67%, ABB remnants of 16.0% +/- 5.89%, and marrow spaces of 38.0% +/- 8.93%. The osteocyte index was 4.43 for bone around ABB and 3.27 in the trabecular bone at a distance from the particles. CONCLUSIONS After 9 years, the tissue pattern appeared composed by residual ABB particles in close contact to the newly formed bone. The bone mineralized matrix around the ABB had collagen fibers randomly oriented and more osteocytes embedded. The results demonstrate both a high level of osteoconductivity and a "biomimetic" behavior over the long term.
Modeling and Analyzing the Coexistence of Wi-Fi and LTE in Unlicensed Spectrum

We leverage stochastic geometry to characterize key performance metrics for neighboring Wi-Fi and LTE networks in unlicensed spectrum. Our analysis focuses on a single unlicensed frequency band, where the locations for the Wi-Fi access points and LTE eNodeBs are modeled as two independent homogeneous Poisson point processes. Three LTE coexistence mechanisms are investigated: 1) LTE with continuous transmission and no protocol modifications; 2) LTE with discontinuous transmission; and 3) LTE with listen-before-talk and random back-off. For each scenario, we derive the medium access probability, the signal-to-interference-plus-noise ratio coverage probability, the density of successful transmissions (DST), and the rate coverage probability for both Wi-Fi and LTE. Compared with the baseline scenario where one Wi-Fi network coexists with an additional Wi-Fi network, our results show that Wi-Fi performance is severely degraded when LTE transmits continuously. However, LTE is able to improve the DST and rate coverage probability of Wi-Fi while maintaining acceptable data rate performance when it adopts one or more of the following coexistence features: a shorter transmission duty cycle, lower channel access priority, or more sensitive clear channel assessment thresholds.
An Investigation of Functional and Anatomical Connectivity Using Magnetic Resonance Imaging

This article examines functional and anatomical connectivity in healthy human subjects measured with magnetic resonance imaging methods. Anatomical connectivity in white matter is obtained from measurements of the diffusion tensor. A Monte-Carlo simulation determines the probability that a particle diffuses between two points, with the probability of a jump in a particular direction from a given voxel being based on the local value of the diffusion tensor components. Functional connectivity between grey matter pixels is assessed without recourse to a specific activation paradigm, by calculating the correlation coefficient between random fluctuations in the blood oxygenation level-dependent signal time course in different pixels. The methods are used to examine the anatomical and functional connectivities between crowns of adjacent gyri. A high functional connectivity was found between grey matter pixels, with white matter displaying only very low correlation. A comparison of the measurements of anatomical and functional connectivity found that there is no simple correlation between these measures, except that low values of functional connectivity were not found together with high values of anatomical connectivity. Furthermore pairs of regions situated around the central sulcus indicated a dependence of the two connectivity measures on each other. These results are in accordance with an interpretation that regions which are clearly directly linked by white matter fiber tracts should show high functional connectivity, but that the inverse need not be true as functional connectivity may also be indirectly mediated via more distant grey matter regions.
Comparison of the Brushless Doubly Fed Reluctance Machine and the Synchronous Reluctance Machine1

1.3 Torque ratio of 6/2 pole BDFRM and the 4 pole SYNCREL with the same copper losses, active copper and current angles of π/4. 13 1.4 α s and α p for maximum torque per 1.7 Maximum-torque-per-total-amperes for various torque levels. 19 1.8 Real and reactive powers under the maximum-torque-per-total-amperes condition with the secondary winding being supplied at the mains frequency (ω sn = 1).
The gateway theory: bridging neural and immune interactions in the CNS

The central nervous system (CNS) is considered an immune-privileged tissue protected by a specific vessel structure, the blood-brain barrier (BBB). Upon infection or traumatic injury in the CNS, the BBB is breached, and various immune cells are recruited to the affected area. In the case of autoimmune diseases in the CNS like multiple sclerosis (MS), autoreactive T cells against some CNS-specific antigens can theoretically attack neurons throughout the CNS. The affected CNS regions in MS patients can be detected as multiple focal plaques in the cerebrum, thoracic cord, and other regions. Vision problems are often associated with the initial phase of MS, suggesting a disturbance in the optic nerves. These observations raise the possibility that there exist specific signals that direct autoreactive T cells past the BBB and into particular sites of the CNS. Using a mouse model of MS, experimental autoimmune encephalomyelitis (EAE), we recently defined the mechanism of the pathogenesis in which regional neural stimulations modulate the status of the blood vessel endothelium to allow the invasion of autoreactive T cells into specific sites of the CNS via the fifth lumbar cord. This gate for autoreactive T cells can be artificially manipulated by removing gravity forces on the hind legs or by electric pulses to the soleus muscles, quadriceps, and triceps of mice, resulting in an accumulation of autoreactive T cells in the intended regions via the activation of regional neurons. Gating blood vessels by regional neural stimulations, a phenomenon we call the gateway theory, has potential therapeutic value not only in preventing autoimmunity, but also in augmenting the effects of cancer immunotherapies.
Valuable orientations capture attention

Visual attention has long been known to be drawn to stimuli that are physically salient or congruent with task-specific goals. Several recent studies have shown that attention is also captured by stimuli that are neither salient nor task relevant, but that are rendered in a colour that has previously been associated with reward. We investigated whether another feature dimension—orientation—can be associated with reward via learning and thereby elicit value-driven attentional capture. In a training phase, participants received a monetary reward for identifying the colour of Gabor patches exhibiting one of two target orientations. A subsequent test phase in which no reward was delivered required participants to search for Gabor patches exhibiting one of two spatial frequencies (orientation was now irrelevant to the task). Previously rewarded orientations robustly captured attention. We conclude that reward learning can imbue features other than colour—in this case, specific orientations—with persistent value.