Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Cancer a Conserved Acidic Patch in the Myb Domain Is Required for Activation of an Endogenous Target Gene and for Chromatin Binding

The c-Myb protein is a transcriptional regulator initially identified by homology to the v-Myb oncoprotein, and has since been implicated in human cancer. The most highly conserved portion of the c-Myb protein is the DNA-binding domain which consists of three imperfect repeats. Many other proteins contain one or more Myb-related domains, including a number of proteins that do not bind directly to DNA. We performed a phylogenetic analysis of diverse classes of Myb-related domains and discovered a highly conserved patch of acidic residues common to all Myb-related domains. These acidic residues are positioned in the first of three alpha-helices within each of the three repeats that comprise the c-Myb DNA-binding domain. Interestingly, these conserved acidic residues are present on a surface of the protein which is distinct from that which binds to DNA. Alanine mutagenesis revealed that the acidic patch of the third c-Myb repeat is essential for transcriptional activity, but neither for nuclear localization nor DNA-binding. Instead, these acidic residues are required for efficient chromatin binding and interaction with the histone H4 N-terminal tail.
On-Line Building Energy Optimization Using Deep Reinforcement Learning

Unprecedented high volumes of data are becoming available with the growth of the advanced metering infrastructure. These are expected to benefit planning and operation of the future power systems and to help customers transition from a passive to an active role. In this paper, we explore for the first time in the smart grid context the benefits of using deep reinforcement learning, a hybrid type of methods that combines reinforcement learning with deep learning, to perform on-line optimization of schedules for building energy management systems. The learning procedure was explored using two methods, Deep Q-learning and deep policy gradient, both of which have been extended to perform multiple actions simultaneously. The proposed approach was validated on the large-scale Pecan Street Inc. database. This highly dimensional database includes information about photovoltaic power generation, electric vehicles and buildings appliances. Moreover, these on-line energy scheduling strategies could be used to provide real-time feedback to consumers to encourage more efficient use of electricity.
Topological Quantum Field Theory and Seiberg-Witten

A topological quantum field theory is introduced which reproduces the Seiberg-Witten invariants of four-manifolds. Dimensional reduction of this topo-logical field theory leads to a new one in three dimensions. Its partition function yields a three-manifold invariant, which can be regarded as the Seiberg-Witten version of Casson's invariant. A Geometrical interpretation of the three dimensional quantum field theory is also given. The field of low dimensional geometry and topology[2] has undergone a dramatic phase of progress in recent years, prompted, to a large extend, by new ideas and discoveries in mathematical physics. The discovery of quantum groups[7] in the study of the Yang-Baxter equation[4] has reshaped the theory of knots and links[10][14][22]; the study of conformal field theory and quantum Chern-Simons theory[18] in physics had a profound impact on the theory of three-manifolds; and most importantly, investigations of the classical Yang-Mills theory led to the creation of the Donaldson theory of four-manifolds[9][6]. Very recently, Witten[19] discovered a new set of invariants of four-manifolds in the study of the Seiberg-Witten monopole equations, which have their origin in supersymmetric gauge theory. The Seiberg-Witten theory, while closely related to Donaldson theory, is much easier to handle. Using Seiberg-Witten theory, proofs of many theorems in Donaldson theory have been simplified, and several important new results have also been obtained[15] [16][11]. However, being only a several 1
Wavelets for Computer Graphics: A Primer Part 2

The Haar wavelets we discussed in Part 1 are just one of many bases that can be used to treat functions in a hierarchical fashion. In this section, we develop a mathematical framework known as multiresolution analysis for studying wavelets [2, 11]. Our examples will continue to focus on the Haar basis, but the more general mathematical notation used here will come in handy for discussing other wavelet bases in later sections.
Conditional deletion of Pip5k1c in sensory ganglia and effects on nociception and inflammatory sensitization

Phosphatidylinositol 4-phosphate 5-kinase type 1 gamma (Pip5k1c) generates phosphatidylinositol 4,5-bisphosphate, also known as PI(4,5)P2 or PIP2. Many pronociceptive signaling pathways and receptor tyrosine kinases signal via PIP2 hydrolysis. Previously, we found that pain signaling and pain sensitization were reduced in Pip5k1c+/− global heterozygous knockout mice. Here, we sought to evaluate the extent to which dorsal root ganglia selective deletion of Pip5k1c affected nociception in mice. Initially, we crossed sensory neuron-selective Advillin-Cre mice with a conditional Pip5k1c knockout (cKO) allele (Pip5k1cfl/fl). However, these mice displayed an early onset proprioceptive deficit. To bypass this early onset phenotype, we used two different tamoxifen-inducible Cre lines (Brn3a-Cre-ERT2 and Advillin-Cre-ERT2) to conditionally delete Pip5k1c in adults. Tamoxifen induced high efficiency deletion of PIP5K1C in dorsal root ganglia and slightly reduced PIP5K1C in spinal cord and brain in Brn3a-Cre-ERT2 × Pip5k1cfl/fl (Brn3a cKO) mice while PIP5K1C was selectively deleted in dorsal root ganglia with no changes in spinal cord or brain in Advillin-Cre-ERT2 × Pip5k1cfl/fl (Advil cKO) mice. Acute thermosensation and mechanosensation were not altered in either line relative to wild-type mice. However, thermal hypersensitivity and mechanical allodynia recovered more rapidly in Brn3a cKO mice, but not Advil cKO mice, following hind paw inflammation. These data collectively suggest that PIP5K1C regulates nociceptive sensitization in more regions of the nervous system than dorsal root ganglia alone.
Serum angiotensin-converting enzyme 2 is an independent risk factor for in-hospital mortality following open surgical repair of ruptured abdominal aortic aneurysm

Open surgical repair (OSR) is a conventional surgical method used in the repair a ruptured abdominal aortic aneurysm (AAA); however, OSR results in high perioperative mortality rates. The level of serum angiotensin-converting enzyme 2 (ACE2) has been reported to be an independent risk factor for postoperative in-hospital mortality following major cardiopulmonary surgery. In the present study, the association of serum ACE2 levels with postoperative in-hospital mortality was investigated in patients undergoing OSR for ruptured AAA. The study enrolled 84 consecutive patients underwent OSR for ruptured AAA and were subsequently treated in the intensive care unit. Patients who succumbed postoperatively during hospitalization were defined as non-survivors. Serum ACE2 levels were measured in all patients prior to and following the surgery using ELISA kits. The results indicated that non-survivors showed significantly lower mean preoperative and postoperative serum ACE2 levels when compared with those in survivors. Multivariate logistic regression analysis also showed that, subsequent to adjusting for potential confounders, the serum ACE2 level on preoperative day 1 showed a significant negative association with the postoperative in-hospital mortality. This was confirmed by multivariate hazard ratio analysis, which showed that, subsequent to adjusting for the various potential confounders, the risk of postoperative in-hospital mortality remained significantly higher in the two lowest serum ACE2 level quartiles compared with that in the highest quartile on preoperative day 1. In conclusion, the present study provided the first evidence supporting that the serum ACE2 level is an independent risk factor for the in-hospital mortality following OSR for ruptured AAA. Furthermore, low serum ACE2 levels on preoperative day 1 were found to be associated with increased postoperative in-hospital mortality. Therefore, the serum ACE2 level on preoperative day 1 may be a potential biomarker or prognostic factor for in-hospital mortality following OSR for ruptured AAA.
THE GLOBAL STRATIGRAPHY OF THE CRETACEOUS-TERTIARY BOUNDARY IMPACT EJECTA

The Chicxulub crater ejecta stratigraphy is reviewed, in the context of the stratigraphy of underlying and overlying rock sequences. The ejecta sequence is regionally grouped in (a) thick polymict and monomict breccia sequences inside the crater and within 300 km from the rim of the crater known from drill holes in and close to the breater, and exposures near the border of Yucatan and Belize; (b) Gulf of Mexico region, <2500 m from the crater, with up to 9 m thick, complex, tsunami-wave influenced, tektite-bearing sequences in shallow marine (<500 m deep) environments and tektite bearing, decimeter thick gravity-flow deposits in deep water sites; (c) an intermediate region between 2500 and 4000 km from the crater where centimeter thick, tektite-bearing layers occur, and (d ) a global distal region with a millimeter thin ejecta layer. The distal ejecta layer is characterized by sub-millimeter sized microkrystites, often rich in Ni-rich spinels and (altered) clinopyroxene. Wherever present, the ejecta layers mark exactly the sudden mass-mortality horizon of the K/T boundary. What exactly caused the mass mortality is still uncertain, but it appears the main event leading to the K/T mass extinctions.
Revising Documents with Text Editors, Handwriting-Recognition Systems, and Speech-Recognition Systems

Twelve participants were given marked-up manuscripts to edit. Results showed that editing was done much faster (50% and 90%) with a simulated handwriting-recognition system and with a simulated speech-recognition system than with a full-screen text editor (Xedit) that participants had experience in using. With the text editor, participants spent considerable time deciding how to locate a revision on the screen, locating it on the screen, and sometimes rereading the document. These behaviors were not necessary with the simulated handwriting and speech systems, in large part because of differences in external feedback provided by the systems. Handwriting-recognition and speech-recognition systems, in addition to being useful principal-support workstations (as each is often envisioned), may also form the bases for potentially good text editors for typists and secretaries.
Multiple Fundamental Frequency Estimation by Summing Harmonic Amplitudes

This paper proposes a conceptually simple and computationally efficient fundamental frequency (F0) estimator for polyphonic music signals. The studied class of estimators calculate the salience, or strength, of a F0 candidate as a weighted sum of the amplitudes of its harmonic partials. A mapping from the Fourier spectrum to a “F0 salience spectrum” is found by optimization using generated training material. Based on the resulting function, three different estimators are proposed: a “direct” method, an iterative estimation and cancellation method, and a method that estimates multiple F0s jointly. The latter two performed as well as a considerably more complex reference method. The number of concurrent sounds is estimated along with their F0s.
The clinical and cellular basis of contact lens-related corneal infections

Microbial keratitis (MK) is the most visually devastating complication associated with contact lens wear. Pseudomonas aeruginosa (PA) is highly invasive in the corneal epithelium and is responsible for more than half of the reported cases of contact lens-related MK. To protect against Pseudomonas-mediated MK, the corneal epithelium has evolved overlapping defense mechanisms that function to protect the ocular surface from microbial invasion. Research has shown that contact lens wear disrupts these protective mechanisms through breakdown of normal homeostatic surface renewal as well as damaging the corneal surface, exposing underlying cell membrane receptors that bind and internalize PA through the formation of lipid rafts. Human clinical trials have shown that initial adherence of PA with resulting increased risk for microbial infection is mediated in part by contact lens oxygen transmissibility. Recently, chemical preserved multipurpose solutions (MPS) have been implicated in increasing PA adherence to corneal epithelial cells, in addition to inducing significant levels of toxic staining when used in conjunction with specific silicone hydrogel lenses. This review summarizes what is currently known about the relationship between contact lenses, the corneal epithelium, MPS, and infection.
Strengthening the Persuasive Impact of Fear Appeals: The Role of Action Framing

Tested, among 110 Dutch undergraduate students, the effects of action frame (AF) under conditions of fear arousal (FA). We predicted an interaction effect between FA and AF that would show that high FA paired with loss information leads to a more positive evaluation of the recommended action than do combinations of (a) high FA with gain information and (b) low FA with either loss or gain information. In the high-threat condition, Ss read information that stressed the severity of breast cancer and the Ss' susceptibility to it. In the low-threat condition, the S's susceptibility to breast cancer was described as low. FA was measured by 4 items on a 9-point scale. Next, Ss then read information about performing breast self-examination that was presented either in a loss frame or in a gain frame. The main dependent variable was a relative evaluation of the importance of monthly breast self-examination performance compared with 5 other health behaviors. A main effect of FA was found, but this effect seemed to be qualified by the predicted interaction between FA and AF, which approached significance. Simple contrast analyses show that Ss in the high FA-loss condition evaluated breast self-examination as more important than Ss in any of the other groups. Further research is suggested. (PsycINFO Database Record (c) 2006 APA, all rights reserved)
Embolotherapy for Pulmonary Arteriovenous Malformations in Patients without Hereditary Hemorrhagic Telangiectasia

Objective To evaluate the clinical and radiological outcomes of transcatheter embolotherapy for treating sporadic pulmonary arteriovenous malformations (PAVMs) that were not associated with hereditary hemorrhagic telangiectasia. Materials and Methods Between January 2001 and June 2008, thirty-five sporadic PAVMs were detected in 23 patients. The clinical follow up consisted of assessing the changes of the signs and symptoms of the PAVMs, and radiological evaluation with chest radiographs or chest CT scans. Results The lower lung regions (63%) and peripheral locations (86%) were the common locations of the PAVMs. Thirty-four PAVMs (97%) had simple architecture (one arterial feeder within a single pulmonary segment). Technical success was achieved in 33 PAVMs (94%); two cases of technical failure were due to catheterization failure (n = 1) and too large a feeding artery (17 mm) that disabled embolotherapy (n = 1). Coils and Amplatz vascular plugs were used in 30 and three PAVMs, respectively. Inadvertent placement of one coil (n = 1) and pulmonary infarction (n = 1) occurred, but no relevant symptoms developed. For the 13 patients with available data, the mean arterial O2 saturation changed significantly from 92% to 98%. Complete or near-complete involution of the sac was observed in 30 of the 33 embolized PAVMs (91%). In these 33 embolized PAVMs, the mean sac diameter significantly decreased from 17.83 mm to 0.68 mm. Conclusion Sporadic PAVMs are mostly the simple type with predominance in the lower lobe and peripheral locations. Transcatheter embolotherapy with coils or Amplatz vascular plugs is a safe and effective treatment for sporadic PAVMs and this provides excellent functional and radiological improvement.
The Homologous Drosophila Transcriptional Adaptors ADA2a and ADA2b Are both Required for Normal Development but Have Different Functions

ABSTRACT In Drosophila and several other metazoan organisms, there are two genes that encode related but distinct homologs of ADA2-type transcriptional adaptors. Here we describe mutations of the two Ada2 genes of Drosophila melanogaster. By using mutant Drosophila lines, which allow the functional study of individual ADA2s, we demonstrate that both Drosophila Ada2 genes are essential. Ada2a and Ada2b null homozygotes are late-larva and late-pupa lethal, respectively. Double mutants have a phenotype identical to that of the Ada2a mutant. The overproduction of ADA2a protein from transgenes cannot rescue the defects resulting from the loss of Ada2b, nor does complementation work vice versa, indicating that the two Ada2 genes of Drosophila have different functions. An analysis of germ line mosaics generated by pole-cell transplantation revealed that the Ada2a function (similar to that reported for Ada2b) is required in the female germ line. A loss of the function of either of the Ada2 genes interferes with cell proliferation. Interestingly, the Ada2b null mutation reduces histone H3 K14 and H3 K9 acetylation and changes TAF10 localization, while the Ada2a null mutation does not. Moreover, the two ADA2s are differently required for the expression of the rosy gene, involved in eye pigment production, and for Dmp53-mediated apoptosis. The data presented here demonstrate that the two genes encoding homologous transcriptional adaptor ADA2 proteins in Drosophila are both essential but are functionally distinct.
Dose-response relationship between physical activity and mental health: the Scottish Health Survey

Objectives: Regular physical activity is thought to be associated with better mental health, although there is a lack of consensus regarding the optimal amount and type of activity to achieve these benefits. The association between mental health and physical activity behaviours was examined among a representative sample of men and women from the Scottish Health Surveys. Methods: Self-reported physical activity was measured and the General Health Questionnaire (GHQ-12) was administered in order to obtain information on current mental health. Participants were 19 842 men and women. Risk estimates per category of physical activity sessions per week were calculated using logistic regression models. Results: Psychological distress (based on a score of 4 or more on the GHQ-12) was evident in 3200 participants. Any form of daily physical activity was associated with a lower risk of psychological distress after adjustment for age, gender, social economic group, marital status, body mass index, long-standing illness, smoking and survey year (OR 0.59, 95% CI 0.52 to 0.66, p<0.001). A dose-response relationship was apparent, with moderate reductions in psychological distress with less frequent activity (OR 0.67, 95% CI 0.61 to 0.75). Different types of activities including domestic (housework and gardening), walking and sports were all independently associated with lower odds of psychological distress, although the strongest effects were observed for sports (OR 0.67, 95% CI 0.54 to 0.82). Conclusion: Mental health benefits were observed at a minimal level of at least 20 min/week of any physical activity, although a dose-response pattern was demonstrated with greater risk reduction for activity at a higher volume and/or intensity.
Optimizing the topology of Bluetooth wireless personal area networks

In this paper, we address the problem of determining an optimal topology for Bluetooth wireless personal area networks (BT-WPAN). In BT-WPAN, multiple communication channels are available, thanks to the use of a frequency hopping technique. The way network nodes are grouped to share the same channel, and which nodes are selected to bridge traffic from a channel to another, has a significant impact on the capacity and the throughput of the system, as well as the nodes' battery lifetime. The determination of an optimal topology is thus extremely important; nevertheless, to the best of our knowledge, this problem is tackled here for the first time. Our optimization approach is based on a model derived from constraints that are specific to the BT-WPAN technology, but the level of abstraction of the model is such that it can be related to the more general field of ad hoc networking. By using a min-max formulation, we find the optimal topology that provides full network connectivity, fulfills the traffic requirements and the constraints posed by the system specification, and minimizes the traffic load of the most congested node in the network, or equivalently its energy consumption. Results show that a topology optimized for some traffic requirements is also remarkably robust to changes in the traffic pattern. Due to the problem complexity, the optimal solution is attained in a centralized manner. Although this implies severe limitations, a centralized solution can be applied whenever a network coordinator is elected, and provides a useful term of comparison for any distributed heuristics.
Snake Venom Disintegrins and Cell Migration

Cell migration is a key process for the defense of pluricellular organisms against pathogens, and it involves a set of surface receptors acting in an ordered fashion to contribute directionality to the movement. Among these receptors are the integrins, which connect the cell cytoskeleton to the extracellular matrix components, thus playing a central role in cell migration. Integrin clustering at focal adhesions drives actin polymerization along the cell leading edge, resulting in polarity of cell movement. Therefore, small integrin-binding proteins such as the snake venom disintegrins that inhibit integrin-mediated cell adhesion are expected to inhibit cell migration. Here we review the current knowledge on disintegrin and disintegrin-like protein effects on cell migration and their potential use as pharmacological tools in anti-inflammatory therapy as well as in inhibition of metastatic invasion.