Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of SPRR3 is associated with tumor cell proliferation and invasion in glioblastoma multiforme

Esophagin, also known as small proline-rich protein 3 (SPRR3), has been demonstrated to be important in the initiation and progression of numerous types of tumor, including colorectal and breast cancer. However, studies concerning the biological functions of SPRR3 in glioblastoma multiforme (GBM) are limited. Therefore, we aimed to identify the functions and molecular mechanisms underlying the role of SPRR3 in GBM. Hypomethylation of SPRR3 was observed and associated with a poor clinical outcome in GBM patients compared with healthy individuals by using gene methylation profiling. The present study was performed to investigate the expression status and effects of SPRR3 in GBM. The U251 cell line was used in the functional analyses. Cell growth was examined by MTT and colony formation assay. Cell invasion was measured using the Transwell invasion assay. The expression of SPRR3 in tissue samples was examined by immunohistochemistry. The results revealed that the overexpression of SPRR3 accelerates U251 cell proliferation and invasion. It was also observed that SPRR3 was markedly upregulated in 72.7% of GBM samples (24/33) compared with the normal tissue. These results suggest that an increased expression of SPRR3 is involved in tumorigenesis.
TWISTOR SPACES, PLURIHARMONIC MAPS AND HARMONIC MORPHISMS

The application of twistor methods to construct harmonic morphisms has proved to be a fruitful approach in the 4-dimensional case, where a variety of examples and, in some cases, even a complete classification of harmonic morphisms has been found. In this paper we generalize this construction to obtain higher-dimensional analogues of these maps. We also prove several results on twistor lifts of pluriharmonic and (1, 1)-geodesic maps.
The Role of Cortical Activity in Experience-Dependent Potentiation and Depression of Sensory Responses in Rat Barrel Cortex

The role of cortical activity in experience-dependent cortical plasticity was studied in the rat barrel cortex. Plasticity was induced by depriving every other whisker in a chessboard pattern, which is known to cause depression of responses to deprived whisker stimulation and potentiation of responses to spared whisker stimulation. Postsynaptic activity was blocked by muscimol released from elvax slow-release polymer located under the dura and over the barrel field. Spared whisker responses potentiated 2.5-fold in layer II/III and 2.9-fold in layer IV of the near-neighbor barrel in animals implanted with saline-elvax. In contrast, in whisker-deprived animals implanted with muscimol-elvax, responses were indistinguishable from those in undeprived animals. Similarly, in the spared barrel itself, spared whisker responses potentiated 1.3-fold in layer IV in animals implanted with saline-elvax but not at all in muscimol-treated animals. Whiskers that were deprived and then allowed to regrow showed depressed responses in saline-elvax-treated animals, in which 40% of the cells in layer II/III and 26% in layer IV were unresponsive to their principal whisker. These values fell to 17 and 3% for layers II/III and IV, respectively, in muscimol-treated animals, and the response magnitude distributions were indistinguishable from undeprived cases. Cortical activity block had no acute effect on the ventroposteriomedial nucleus responses and had a transient facilitatory effect after 4 d of muscimol treatment, which returned to baseline as the muscimol treatment wore off. We conclude from these studies that cortical activity is required for potentiation and depression of sensory responses in barrel cortex.
Assessing the Impact of Textual Content Concreteness on Helpfulness in Online Travel Reviews

The online travel review has become one of the most influential information sources for travelers’ decision making. This research primarily aims to examine the relationship between review textual content concreteness and review helpfulness in the tourism context. In particular, we examine how this relationship plays out under two individual circumstances, namely, temporal distance and risk–benefit tendency. Based on the construal level theory and feeling-as-information theory, two experiments are conducted to test whether the influence of review concreteness is moderated by temporal distance and risk–benefit tendency. The results show that the main effect of review concreteness is significant; however, in contrast to the assumptions of theories and results of relevant studies, both interaction effects of temporal distance and risk–benefit tendency are not. Finally, we interpret the findings and discuss the implications and limitations of this research.
Measuring and Understanding Team Development by Capturing Self-assessed Enthusiasm and Skill Levels

To prepare graduates for today's work environment, they must be immersed in positive (and perhaps negative) small group experiences in their courses, which will in turn provide a basic understanding of how teams form and develop over time. In the fall of 2009, we started exploring how software development teams form and interact in a computer science college capstone course setting. Our initial findings were presented at ICER 2010 in Aarhus, Denmark. The focus of our research was on the experiences of computer science college course teams as compared and contrasted to the theory of Bruce Tuckman's stages of small group development model, which he characterized as forming, storming, norming, performing, and adjourning. We continued data collection with the computer science capstone course in the fall of 2010 and added an information systems capstone course as well. At the conclusion of the spring 2014 semester, we have collected and analyzed data for a total of 5 academic years from nine cohorts of students taught by five instructors involving 215 students on 51 teams. Each year, participants repeatedly self-assessed their enthusiasm and skill levels over time using a questionnaire by agreeing or disagreeing to statements. The data shows patterns similar to that of Tuckman's model. Since most people find Tuckman's model easy to understand, it may provide an effective tool to teach teamwork and monitor team development. In addition to briefly presenting our empirical findings in this article, we provide a simple conceptualization of Tuckman's model that can be captured in two data points: enthusiasm and skill level. By comparing changes in these two dimensions over time, team development can be tracked through the various Tuckman stages of small group development. We also provide a minicurriculum which can be used to introduce students to Tuckman's model and provide them insight into what leadership style works best in each of the development stages.
Comparison of the Neodymium-doped Yttrium Aluminum Garnet Capsulotomy Rate with Viscoimplantation and the Hydroimplantation Intraocular Lens Technique

Purpose To investigate the rate of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy in the hydroimplantation intraocular lens (IOL) technique. Methods This retrospective study was comprised of 6,192 eyes in 3,790 patients who underwent surgery from January 2013 to September 2017 and then were followed up for at least 1 year. The eyes of these patients were divided into two groups: either viscoimplantation or hydroimplantation. The follow-up examinations were carried out on the 1st day, 4th day, 1st month, and 3 months to 1 year postoperatively. The Nd:YAG capsulotomy rates were evaluated by the different IOL implantation techniques and IOL materials. Results The mean follow-up duration of the patients was in the viscoimplantation group 14.85 ± 2.43 and 15.05 ± 1.93 months in the hydroimplantation group. The Nd:YAG capsulotomy rate was significantly lower in the hydroimplantation group compared with the viscoimplantation group for the entire hydrophilic IOL model (p < 0.001). In addition, the Nd:YAG rate was lower in the hydroimplantation group that used a hydrophilic IOL than it was in the viscoimplantation group, which used a hydrophobic IOL. Conclusions The hydroimplantation technique reduced the Nd:YAG capsulotomy rate.
P-SVM Variable Selection for Discovering Dependencies Between Genetic and Brain Imaging Data

The joint analysis of genetic and brain imaging data is the key to understand the genetic underpinnings of brain dysfunctions in several psychiatric diseases known to have a strong genetic component. The goal is to identify associations between genetic and functional or morphometric brain measurements. We here suggest a machine learning method to solve this task, which is based on the recently proposed Potential Support Vector Machine (P-SVM) for variable selection, a subsequent k-NN classification and an estimation of the effect of 'correlations by chance'. We apply it to the detection of associations between candidate single nucleotide polymorphisms (SNPs) and volumetric MRI measurements in alcohol dependent patients and healthy controls.
The Small G Protein AtRAN1 Regulates Vegetative Growth and Stress Tolerance in Arabidopsis thaliana

The evolutionarily conserved small G-protein Ran plays important role in nuclear translocation of proteins, cell cycle regulation, and nuclear envelope maintenance in mammalian cells and yeast. Arabidopsis Ran proteins are encoded by a family of four genes and are highly conserved at the protein level. However, their biological functions are poorly understood. We report here that AtRAN1 plays an important role in vegetative growth and the molecular improvement of stress tolerance in Arabidopsis. AtRAN1 overexpression promoted vegetative growth and enhanced abiotic tolerance, while the atran1 atran3 double mutant showed higher freezing sensitivity than WT. The AtRAN1 gene is ubiquitously expressed in plants, and the expression levels are higher in the buds, flowers and siliques. Subcellular localization results showed that AtRAN1 is mainly localized in the nucleus, with some present in the cytoplasm. AtRAN1 could maintain cell division and cell cycle progression and promote the formation of an intact nuclear envelope, especially under freezing conditions.
Measuring the Structural Similarity of Semistructured Documents Using Entropy

We propose a technique for measuring the structural similarity of semistructured documents based on entropy. After extracting the structural information from two documents we use either Ziv-Lempel encoding or Ziv-Merhav crossparsing to determine the entropy and consequently the similarity between the documents. To the best of our knowledge, this is the first true linear-time approach for evaluating structural similarity. In an experimental evaluation we demonstrate that the results of our algorithm in terms of clustering quality are on a par with or even better than existing approaches.
A Backmapping Approach for Graph-Based Object Tracking

Model-based methods play a central role to solve different problems in computer vision. A particular important class of such methods rely on graph models where an object is decomposed into a number of parts, each one being represented by a graph vertex. A graph model-based tracking algorithm has been recently introduced in which a model is generated for a given frame (reference frame) and used to track a target object in the subsequent ones. Because the view of an object changes along the video sequence, the solution updated the model using affine transformations. This paper proposes a different approach and improves the previous one in several ways. Firstly, instead of updating the model, each analyzed frame is backmapped to the model space, thus providing more robustness to the method because model parameters do not have to be modified. A different method for model generation based on user traces has also been implemented and used. This model generation approach is much simpler and user-friendly. Finally, a graph-matching algorithm that has been recently proposed is used for object tracking. This new algorithm is more efficient and leads to better matching results. Experimental results using synthetic and real sequences from the CAVIAR project are shown and discussed.
PENGARUH KECERDASAN EMOSIONAL DAN KECERDASAN SPIRITUAL TERHADAP KINERJA KARYAWAN (Studi pada Karyawan PT Industri Kereta Api (Persero) Madiun – Jawa Timur

Development and growth of the business world as well as changes in the bureaucratic world has spawned a variety of concepts and understanding of human resource management. These experiences have shaped and strengthened the concept of HRM to be more robust and character. Every human being wants to be excellent in every way to achieve the goals of the organization, so that required the Performance Employees who have the intelligence not only on intellectual intelligence, but also supported by emotional intelligence and spiritual intelligence. The influence of emotional intelligence and spiritual intelligence on employee performance is important, because one of the determinants of employee performance and organizational success as well as the key to progress in the present and the future. The purpose of this study was to determine the significant effect of Emotional Intelligence and Spiritual Intelligence simultaneously and partially on the performance of employees. The type of research that used in this research was explanatory research with a quantitative approach to determine the effect of variables, where the hypothesis test using descriptive statistic analyzes and multiple linear regression analyzes. The samples used in this study as many as 90 employees of PT. Industri Kereta Api (Persero) Kеywords: Emotional Intelligence, Spiritual Intelligence, and Employees Performance. АBSTRАK Perkembangan dan pertumbuhan dunia bisnis serta berbagai perubahan dalam dunia birokrasi telah melahirkan berbagai konsep dan pemahaman tentang manajemen sumber daya manusia. Berbagai pengalaman tersebut telah membentuk dan mendorong penguatan konsep MSDM secara lebih kokoh dan berkarakter. Setiap manusia ingin berprestasi dalam segala hal untuk mencapai tujuan organisasi, sehingga diperlukan Kinerja Karyawan yang memiliki kecerdasan yang tidak hanya pada kecerdasan intelektual saja, namun juga didukung oleh Kecerdasan Emoisional dan Kecerdasan Spiritual. Pengaruh kecerdasan emosional dan kecerdasan spiritual terhadap kinerja karyawan adalah penting, karena salah satu penentu Kinerja Karyawan dan keberhasilan organisasi serta kunci untuk kemajuan di masa kini dan masa depan. Sehubungan dengan itu latar belakang masalah yang diangkat dalam penelitian ini adalah bagaimana tanggapan karyawan PT Industri Kereta Api (Persero) pengaruh kecerdasan emosi dan kecerdasan spiritual terhadap kinerja karyawan. Tujuan dari penelitian ini adalah untuk mengetahui Kecerdasan Emosional dan Kecerdasan Spiritual berpengaruh signifikan secara stimultan dan parsial terhadap kinerja karyawan. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian penjelasan dengan pendekatan kuantitatif untuk mengetahui pengaruh antar variabel, dimana pengujian hipotesis menggunakan analisis statitik deskriptif dan analisis regresi linier berganda. Jumlah sampel yang digunakan dalam penelitian ini sebanyak 90 orang pegawai PT Industri Kereta Api (Persero). Kаtа Kunci: Kecerdasan Emosional, Kecerdasan Spiritual, dan Kinerja Karyawan.
Testing Differential Holistic Processing Within a Face: No Evidence of Asymmetry from the Complete Composite Task

The composite face task is one of the most popular research paradigms for measuring holistic processing of upright faces. The exact mechanism underlying holistic processing remains elusive and controversial, and some studies have suggested that holistic processing may not be evenly distributed, in that the top-half of a face might induce stronger holistic processing than its bottom-half counterpart. In two experiments, we further examined the possibility of asymmetric holistic processing. Prior to Experiment 1, we confirmed that perceptual discriminability was equated between top and bottom face halves; we found no differences in performance between top and bottom face halves when they were presented individually. Then, in Experiment 1, using the composite face task with the complete design to reduce response bias, we failed to obtain evidence that would support the notion of asymmetric holistic processing between top and bottom face halves. To further reduce performance variability and to remove lingering holistic effects observed in the misaligned condition in Experiment 1, we doubled the number of trials and increased misalignment between top and bottom face halves to make misalignment more salient in Experiment 2. Even with these additional manipulations, we were unable to find evidence indicative of asymmetric holistic processing. Taken together, these findings suggest that holistic processing is distributed homogenously within an upright face.
Teacher Non-Verbal Behaviour as Part of Multimodal Interaction to Children With Autism

The paper discusses non verbal behavior performed and exploited by a teacher of children with autism as part of multimodal interaction in transferring knowledge. Data were collected from one teaching session carried out by a teacher and five children with autism. Data in the forms of body language, facial gesture, proximity, kinesics and other aspects of non verbal behavior were collected from such a session. The results show that strategies in exploiting non verbal aspects of the interaction are influenced by the autistic conditions of the children. As each of students in the class has different conditions, the teacher should design different non verbal approaches in transferring the knowledge to the children. In general, the teacher always equipped her utterances with body movements, facial gestures, standing position as well as paralinguistic resources such as intonation and loudness of speech. The strategies are performed to support the verbal behavior the teacher has in the teaching session and both represent multimodal interaction in the session. It is expected that the results of this research can be good benefits for other teachers or parents of children with autism in the process of assisting the children. Keywords—autism, verbal, non verbal, behavior, multimodal
Symmetric/skew-symmetric homogeneous matrix descriptor (regular) differential systems with consistent initial conditions

This paper introduces the results of Thompson's canonical form under congruence for pairs of complex matrices with symmetric and skew symmetric structural properties to the solution of higher order linear matrix homogeneous differential systems. Under this approach, the main equation is divided into five sub-systems whose solutions are derived. Note that the regularity or singularity of matrix pencil predetermines the number of sub-systems. The special properties of such systems may be appeared in engineering and even in some financial models.
Electrophysiological Properties of AMPA Receptors Are Differentially Modulated Depending on the Associated Member of the TARP Family

The family of AMPA receptors is encoded by four genes that are differentially spliced to result in the flip or flop versions of the four subunits GluR1 to GluR4. GluR2 is further modified at the so-called Q/R site by posttranscriptional RNA editing. Delivery of AMPA receptors to the plasma membrane and synaptic trafficking are controlled by transmembrane AMPA receptor regulatory proteins (TARPs). Additionally, TARPs influence essential electrophysiological properties of AMPA receptor channels such as desensitization and agonist efficacies. Here, we compare the influence of all known TARPs (γ2, γ3, γ4, and γ8) on agonist-induced currents of the four AMPA receptor subunits, including flip and flop splice variants and editing variants. We show that, although agonist-induced currents of all homomeric AMPA receptor subunits as well as all heteromeric combinations tested are significantly potentiated when coexpressed with members of the TARP family in Xenopus laevis oocytes, the extent of TARP-mediated increase in agonist-induced responses is highly dependent on both the AMPA receptor subunit and the coexpressed TARP. Moreover, we demonstrate that the splice variant of the AMPA receptor plays a key role in determining the modulation of electrophysiological properties by associated TARPs. We furthermore present evidence that individual TARP–AMPA receptor interactions control the degree of desensitization of AMPA receptors. Consequently, because of their subunit-specific impact on the electrophysiological properties, TARPs play a major role as modulatory subunits of AMPA receptors and thus contribute to the functional diversity of AMPA receptors encountered in the CNS.
Genome-Wide Association Study of Periodontal Health Measured by Probing Depth in Adults Ages 18−49 years

The etiology of chronic periodontitis clearly includes a heritable component. Our purpose was to perform a small exploratory genome-wide association study in adults ages 18–49 years to nominate genes associated with periodontal disease−related phenotypes for future consideration. Full-mouth periodontal pocket depth probing was performed on participants (N = 673), with affected status defined as two or more sextants with probing depths of 5.5 mm or greater. Two variations of this phenotype that differed in how missing teeth were treated were used in analysis. More than 1.2 million genetic markers across the genome were genotyped or imputed and tested for genetic association. We identified ten suggestive loci (p-value ≤ 1E-5), including genes/loci that have been previously implicated in chronic periodontitis: LAMA2, HAS2, CDH2, ESR1, and the genomic region on chromosome 14q21-22 between SOS2 and NIN. Moreover, we nominated novel loci not previously implicated in chronic periodontitis or related pathways, including the regions 3p22 near OSBPL10 (a lipid receptor implicated in hyperlipidemia), 4p15 near HSP90AB2P (a heat shock pseudogene), 11p15 near GVINP1 (a GTPase pseudogene), 14q31 near SEL1L (an intracellular transporter), and 18q12 in FHOD3 (an actin cytoskeleton regulator). Replication of these results in additional samples is needed. This is one of the first research efforts to identify genetic polymorphisms associated with chronic periodontitis-related phenotypes by the genome-wide association study approach. Though small, efforts such this are needed in order to nominate novel genes and generate new hypotheses for exploration and testing in future studies.
Merging multi-source precipitation products or merging their simulated hydrological flows to improve streamflow simulation

ABSTRACT Satellite and reanalysis precipitation products are widely utilized for streamflow simulation, which is one critical hydrological application, especially for ungauged regions. Possible ways to improve streamflow simulation are investigated in this study by merging multi-source precipitation products, or directly merging streamflow simulated with different precipitation products. Two satellite-based precipitation products, Tropical Rainfall Measuring Mission (3B42 Version 7) and Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks-Climate Data Record (PERSIANN-CDR), and one reanalysis precipitation product, National Centers for Environment Prediction-Climate Forecast System Reanalysis (NCEP-CFSR) are selected. Bayesian model averaging (BMA) is used to merge multi-source precipitation estimates and streamflow simulations. The results show that merging multi-source precipitation products made little difference to improve streamflow simulation. Merging multi-source streamflow simulations using the BMA generally achieved better performance on streamflow simulation, indicating that this approach is more efficient than merging multi-source precipitation products.