Miracle-dz/UniFAR-FTUs huggingface dataset:
A class of digitally programmable nth‐order filters

A family of new high‐order filters capable of providing all filter functions without changing the circuit topology is proposed for integrated circuit applications. The proposed filters are based on simple active elements, namely, digitally controlled current amplifiers (DCCAs) and unity gain voltage buffers (VBs). Gains of DCCAs are digitally programmed to adjust the coefficients of transfer functions. R2R ladders are also utilized to increase the tuning flexibility of the proposed filters. A filter replicating the famous KHN biquad is extended to realize general nth‐order filters. Comparison with the recent works shows that the proposed approach results in more efficient realizations compared with its counterparts based on other current‐mode active elements. Experimental results obtained from a fourth‐order filter implemented using devices fabricated in a 0.35‐µm CMOS process are provided. Copyright © 2011 John Wiley & Sons, Ltd.
Non-Asymptotic Analysis of Stochastic Approximation Algorithms for Machine Learning

We consider the minimization of a convex objective function defined on a Hilbert space, which is only available through unbiased estimates of its gradients. This problem includes standard machine learning algorithms such as kernel logistic regression and least-squares regression, and is commonly referred to as a stochastic approximation problem in the operations research community. We provide a non-asymptotic analysis of the convergence of two well-known algorithms, stochastic gradient descent (a.k.a. Robbins-Monro algorithm) as well as a simple modification where iterates are averaged (a.k.a. Polyak-Ruppert averaging). Our analysis suggests that a learning rate proportional to the inverse of the number of iterations, while leading to the optimal convergence rate in the strongly convex case, is not robust to the lack of strong convexity or the setting of the proportionality constant. This situation is remedied when using slower decays together with averaging, robustly leading to the optimal rate of convergence. We illustrate our theoretical results with simulations on synthetic and standard datasets.
Wireless Power Transfer-Based Multi-Pair Two-Way Relaying With Massive Antennas

In this paper, we study a multi-pair two-way relay network consisting of two groups of user equipments (UEs), who want to exchange information through a common relay equipped with massive antennas. In the multiple access phase, the UEs transmit information to the relay using the energy harvested in the last time block, and the relay decodes information using zero-forcing (ZF) or maximal ratio combining (MRC) technique. In the broadcasting phase, the relay performs simultaneous wireless information and power transfer (SWIPT), and each UE receives energy and information using the power-splitting scheme. Due to the channel hardening effect of the large-scale antenna array, the harvested energy of each UE in each time block is asymptotically constant. Based on the derived achievable rates of UEs, a multi-objective optimization problem (MOOP) is formulated to maximize the achievable rates of all the pairs. Through solving the MOOP, the power-splitting ratios of UEs can be determined in closed-form for the ZF-based relaying. For the MRC-based relaying, a two-stage iterative Pareto improvement algorithm is proposed to achieve the Pareto optimality. Simulation results are presented to validate our theoretical analysis and verify the efficiency of our proposed algorithm in improving the system rate.
The Verlinde Formula for Parabolic Bundles

Let Σg be a compact Riemann surface of genus g, and G = SU(n). The central element c = diag(e2πid/n, …, e2πid/n) for d coprime to n is introduced. The Verlinde formula is proved for the Riemann–Roch number of a line bundle over the moduli space Mg, 1(c, Λ) of representations of the fundamental group of a Riemann surface of genus g with one boundary component, for which the loop around the boundary is constrained to lie in the conjugacy class of cexp(Λ) (for Λ ∈ t+), and also for the moduli space Mg, b(c, Λ) of representations of the fundamental group of a Riemann surface of genus g with s + 1 boundary components for which the loop around the 0th boundary component is sent to the central element c and the loop around the jth boundary component is constrained to lie in the conjugacy class of exp(Λ(j)) for Λ(j) ∈ t+. The proof is valid for Λ(j) in suitable neighbourhoods of 0.
Heparin reduces nonspecific eosinophil staining artifacts in mass cytometry experiments

The analysis of heterogeneous cell samples by mass cytometry (CyTOF) relies on the assumption that metal labeled antibodies accurately bind to their target antigens. We report a previously unappreciated experimental artifact of non‐specific antibody binding by eosinophils during intracellular CyTOF analysis of human whole blood samples. We hypothesized that this non‐specific binding results from a charge‐based interaction between the metal‐labeled antibodies and highly cationic proteins found in eosinophillic granules and found that this non‐specific staining artifact could be reduced to background levels with a simple blocking protocol using heparin as a competing anionic protein. This protocol eliminates a potential source of erroneous data interpretation in all experiments involving intracellular staining of human whole blood samples, and allows accurate assessment of dynamic changes in intracellular proteins in eosinophils by CyTOF. © 2016 International Society for Advancement of Cytometry
Combined human papillomavirus typing and TP53 mutation analysis in distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma

In head and neck squamous cell carcinoma (HNSCC), the occurrence of concurrent lung malignancies poses a significant diagnostic challenge because metastatic HNSCC is difficult to discern from second primary lung squamous cell carcinoma (SCC). However, this differentiation is crucial because the recommended treatments for metastatic HNSCC and second primary lung SCC differ profoundly.
Response of Surface Temperature to Afforestation in the Kubuqi Desert, Inner Mongolia

In this study, micrometeorological observations in a shrub ecosystem and an adjacent poplar plantation forest ecosystem in the Kubuqi Desert, Inner Mongolia, China, are used to evaluate the theory of intrinsic biophysical mechanism (IBPM) and to investigate the biophysical effects of afforestation. Results indicate that after forcing energy balance closure to the observed fluxes, the IBPM theory agrees very well with the observed temporal variations in the surface temperature and with the observed temperature difference between the paired sites at the half‐hourly time scale. Afforestation activity in this dryland landscape has a cooling effect (−0.5 ± 0.2 K) in the daytime in all the seasons and a warming effect (0.2 ± 0.1 K) in the nighttime during the winter, spring and, autumn but a cooling effect (−1.0 ± 0.3 K) in the summer at night. These temperature changes are decomposed into contributions from changes in surface albedo, surface roughness, Bowen ratio, and ground heat flux. Comparison is made between the IBPM theory and the theory of the decomposed temperature metric.
Infant mortality in white‐faced capuchins: The impact of alpha male replacements

Infanticide is common in the context of alpha male replacements (AMR), particularly in groups where alpha males experience high reproductive skew and the infants are unlikely to be related to a new alpha male. We examined the relationship between the rate of infant mortality, infant age, and the occurrence and type of AMR in white‐faced capuchin monkeys (Cebus capucinus imitator) of the Santa Rosa population in Sector Santa Rosa, Área de Conservación Guanacaste. Specifically, we investigated how the source of the new alpha male (coresident or extragroup) and relative aggression level during AMRs influenced infant mortality in this species. Between 1986 and 2015, we recorded 221 births in five study groups. Infants present at the time of an AMR, or born within 5.5 months following an AMR (i.e., conceived prior to AMR), experienced significantly higher mortality than those born during periods of group stability. Infant age was a significant predictor of infant survival, with the probability of surviving increasing by 0.4% for each additional day older an infant was at the time of the AMR. Infant mortality rates did not differ between AMRs by coresident males and extragroup males, possibly because the degree of relatedness between infants and new alphas did not significantly differ between coresident and extragroup AMRs. Infant mortality rates did not differ significantly between aggressive AMRs and more peaceful AMRs. Our results are consistent with predictions derived from the sexual selection hypothesis (SSH) of infanticide and suggest that future studies examine the role of testosterone as an underlying proximate mechanism for the aggression leading to this behavior. We argue that the sexual selection and generalized aggression hypotheses (GAH) of infanticide are best considered as different levels of analysis rather than competing hypotheses.
Preliminary Results and Learning Curve of the Minimally Invasive Chevron Akin Operation for Hallux Valgus

ABSTRACT Minimally invasive surgery is increasing in popularity. It is relevant in hallux valgus surgery owing to the potential for reduced disruption of the soft tissues and improved wound healing. We present our results and assess the learning curve of the minimally invasive Chevron Akin operation for hallux valgus. A total of 120 consecutive feet underwent minimally invasive Chevron Akin for symptomatic hallux valgus, of which 14 were excluded. They were followed up for a mean of 25 (range 18 to 38) months. The patients were clinically assessed using the American Orthopaedic Foot and Ankle Society score. Complications and patient satisfaction were recorded. The radiographs were analyzed and measurements recorded for hallux valgus and intermetatarsal angle correction. The mean age of the patients undergoing surgery was 55 (range 25 to 81) years. Of the 78 patients, 76 (97.4%) were female and 2 (2.6%) were male; 28 (35.9%) cases were bilateral. The mean American Orthopaedic Foot and Ankle Society score improved from 56 (range 23 to 76) preoperatively to 87 (range 50 to 100) postoperatively (p < .001). The mean hallux valgus and intermetatarsal angles preoperatively were 29.7° (range 12° to 46°) and 14.0° (range 8° to 20°). The corresponding postoperative angles were 10.3° (range 0° to 25°) and 7.6° (range 3° to 15°; p < .001). The patients were satisfied with the results of surgery in 87% of cases (92 of 106). The incidence of reoperation was 14% (15 of 106). These are the only reported results for this technique. They display a steep associated learning curve. However, the results are promising, and the learning curve is comparable to that for open hallux valgus surgery.
Serum Sodium and Cognition in Older Community-Dwelling Men.

BACKGROUND AND OBJECTIVES Mild hyponatremia is a common finding in older adults; however, the association of lower serum sodium with cognition in older adults is currently unknown. We determined whether lower normal serum sodium is associated with cognitive impairment and risk of cognitive decline in community-dwelling older men. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Five thousand four hundred thirty-five community-dwelling men aged ≥65 years who participated in Osteoporotic Fractures in Men, a cohort study with a median follow-up for cognitive function of 4.6 years, were included in this analysis. Multivariable logistic regression was used to examine the association between baseline fasting serum sodium levels and the odds of prevalent cognitive impairment (cross-sectional analysis; modified Mini-Mental Status [3MS] score <1.5 SD [<84] below or Trail Making Test Part B time >1.5 SD above the mean [>223 seconds]) and cognitive decline (prospective analysis [n=3611]; decrease in follow-up 3MS score or increase in Trails B time >1.5 SD of the mean score/time change [>9 or >67 seconds]). RESULTS Participants were aged 74±6 years with a fasting mean serum sodium level of 141±3 mmol/L. Fifteen percent (n=274), 12% (n=225), and 13% (n=242) had prevalent cognitive impairment in tertiles 1, 2, and 3, respectively. After adjustment, lower serum sodium was associated with prevalent cognitive impairment (tertile 1 [126-140 mmol/L] versus tertile 2 [141-142 mmol/L], odds ratio [OR], 1.30; 95% confidence interval [95% CI], 1.06 to 1.61). Fourteen percent (n=159), 10% (n=125), and 13% (n=159) had cognitive decline in tertiles 1, 2, and 3, respectively. Lower serum sodium was also associated with cognitive decline (tertile 1 versus tertile 2, OR, 1.37; 95% CI, 1.06 to 1.77). Tertile 3 (143-153 mmol/L) was additionally associated with cognitive decline. Results were similar in sensitivity analyses according to clinical cut-offs and by quartiles. CONCLUSIONS In community-dwelling older men, serum sodium between 126-140, and 126-140 or 143-153 mmol/L, are independently associated with prevalent cognitive impairment and cognitive decline, respectively.
Mammographic Density Change With Estrogen and Progestin Therapy and Breast Cancer Risk

Background: Estrogen plus progestin therapy increases both mammographic density and breast cancer incidence. Whether mammographic density change associated with estrogen plus progestin initiation predicts breast cancer risk is unknown. Methods: We conducted an ancillary nested case-control study within the Women’s Health Initiative trial that randomly assigned postmenopausal women to daily conjugated equine estrogen 0.625 mg plus medroxyprogesterone acetate 2.5 mg or placebo. Mammographic density was assessed from mammograms taken prior to and one year after random assignment for 174 women who later developed breast cancer (cases) and 733 healthy women (controls). Logistic regression analyses included adjustment for confounders and baseline mammographic density when appropriate. Results: Among women in the estrogen plus progestin arm (97 cases/378 controls), each 1% positive change in percent mammographic density increased breast cancer risk 3% (odds ratio [OR] = 1.03, 95% confidence interval [CI] = 1.01 to 1.06). For women in the highest quintile of mammographic density change (>19.3% increase), breast cancer risk increased 3.6-fold (95% CI = 1.52 to 8.56). The effect of estrogen plus progestin use on breast cancer risk (OR = 1.28, 95% CI = 0.90 to 1.82) was eliminated in this study, after adjusting for change in mammographic density (OR = 1.00, 95% CI = 0.66 to 1.51). Conclusions: We found the one-year change in mammographic density after estrogen plus progestin initiation predicted subsequent increase in breast cancer risk. All of the increased risk from estrogen plus progestin use was mediated through mammographic density change. Doctors should evaluate changes in mammographic density with women who initiate estrogen plus progestin therapy and discuss the breast cancer risk implications.
Impact of Alien Plant Invaders on Pollination Networks in Two Archipelagos

Mutualistic interactions between plants and animals promote integration of invasive species into native communities. In turn, the integrated invaders may alter existing patterns of mutualistic interactions. Here we simultaneously map in detail effects of invaders on parameters describing the topology of both plant-pollinator (bi-modal) and plant-plant (uni-modal) networks. We focus on the invader Opuntia spp. , a cosmopolitan alien cactus. We compare two island systems: Tenerife (Canary Islands) and Menorca (Balearic Islands). Opuntia was found to modify the number of links between plants and pollinators, and was integrated into the new communities via the most generalist pollinators, but did not affect the general network pattern. The plant uni-modal networks showed disassortative linkage, i.e. species with many links tended to connect to species with few links. Thus, by linking to generalist natives, Opuntia remained peripheral to network topology, and this is probably why native network properties were not affected at least in one of the islands. We conclude that the network analytical approach is indeed a valuable tool to evaluate the effect of invaders on native communities.
ATME: Accurate Traffic Matrix Estimation in Both Public and Private Datacenter Networks

Understanding the pattern of end-to-end traffic flows in datacenter networks (DCNs) is essential to many DCN designs and operations (e.g., traffic engineering and load balancing). However, little research work has been done to obtain traffic information efficiently and yet accurately. Researchers often assume the availability of traffic tracing tools (e.g., OpenFlow) when their proposals require traffic information as input, but these tools may have high monitoring overhead and consume significant switch resources even if they are available in a DCN. Although estimating the traffic matrix (TM) between origin-destination pairs using only basic switch SNMP counters is a mature practice in IP networks, traffic flows in DCNs show totally different characteristics, while the large number of redundant routes in a DCN further complicates the situation. To this end, we propose to utilize resource provisioning information in public cloud datacenters and the service placement information in private datacenters for deducing the correlations among top-of-rack switches, and to leverage the uneven traffic distribution in DCNs for reducing the number of routes potentially used by a flow. These allow us to develop ATME as an efficient TM estimation scheme that achieves high accuracy for both public and private DCNs. We compare our two algorithms with two existing representative methods through both experiments and simulations; the results strongly confirm the promising performance of our algorithms.
The effects of breastfeeding on childhood BMI: a propensity score matching approach

Background Many studies have found a statistical association between breastfeeding and childhood adiposity. This paper investigates whether breastfeeding has an effect on subsequent childhood body mass index (BMI) using propensity scores to account for confounding. Methods We use data from the Millennium Cohort Study, a nationally representative UK cohort survey, which contains detailed information on infant feeding and childhood BMI. Propensity score matching is used to investigate the mean BMI in children breastfed exclusively and partially for different durations of time. Results We find statistically significant influences of breastfeeding on childhood BMI, particularly in older children, when breastfeeding is prolonged and exclusive. At 7 years, children who were exclusively breastfed for 16 weeks had a BMI 0.28 kg/m2 (95% confidence interval 0.07 to 0.49) lower than those who were never breastfed, a 2% reduction from the mean BMI of 16.6 kg/m2. Conclusions For this young cohort, even small effects of breastfeeding on BMI could be important. In order to reduce BMI, breastfeeding should be encouraged as part of wider lifestyle intervention. This evidence could help to inform public health bodies when creating public health guidelines and recommendations.
An evaluation of thiol/disulphide homeostasis in patients with psoriasis

Introduction The role of oxidative stress in the pathogenesis of psoriasis has been investigated in previous studies with conflicting results. On the other hand, well-established treatments currently used in psoriasis exert their effects via a boost of oxidative stress. Recently, a strong positive association between psoriasis, metabolic syndrome and dyslipidemia has also been described showing the complex nature of the disease. Aim To examine thiol/disulphide homeostasis, a newly developed homeostasis assay in psoriasis and evaluate the possible association between thiol/disulphide homeostasis and dyslipidemia in psoriasis. Material and methods The study population included 92 psoriasis patients and 71 healthy subjects. Serum native thiol, total thiol and disulphide levels were investigated in patients with psoriasis and in healthy subjects. In addition, lipid profile (serum total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) levels were investigated in both groups. The association between thiol-disulphide parameters and dyslipidemia was also evaluated. Results Serum total cholesterol and triglyceride levels were found to be higher in patients with psoriasis than in the healthy group. Lower plasma disulphide and higher native thiol levels were found in patients with psoriasis indicating an antioxidant status. Conclusions To our knowledge, this is the first study showing the shift of dynamic thiol/disulphide homeostasis towards the thiol form in psoriasis which indicate higher antioxidant status.
STRENGTH DEVELOPMENT AND DURABILITY OF CONCRETES CAST AND CURED AT 0 C

The paper describes an experimental investigation into the strength development of CSA Type 10 (ASTM Type I) and CSA Type 30 (ASTM) Type III) cement concretes and durability of CSA Type 30 cement concretes, cast at 0 C and cured at 0 C in seawater relative to conventionally cast and cured concretes. All concretes incorporated air-entraining admixtures and had plastic air contents of between 4 and 6 percent. Strength development of all concretes at any temperature is dependent upon the water-cementitious ratio. Low-temperature casting and curing is not necessarily detrimental to the strength development of low water-cement ratio concretes. The resistance to freezing and thawing of air-entrained Type 30 cement concretes of water-cement ratios below 0.50 is excellent regardless of casting and curing temperature.
The effects of long-term diet and omega-3 fatty acid supplementation on coagulation factor VII and serum phospholipids with special emphasis on the R353Q polymorphism of the FVII gene

Summary The aim of the present study was to investigate the effect of long-term diet and very long chain n-3 fatty acids (VLC n-3) intervention on plasma coagulation factor VII (FVII), cholinecontaining phospholipids (PC) and triglycerides (TG), especially related to the R353Q polymorphism of the FVII gene. The present investigation included 219 subjects from the Diet and Omega-3 Intervention Trial on atherosclerosis (DOIT), a 2x2 factorial designed study in elderly men with long-standing hypercholesterolemia. The subjects were randomly allocated to receive placebo capsules (corn oil) (control), placebo capsules and dietary advice (“Mediterranean type” diet), VLC n-3 capsules, or VLC n-3 capsules and dietary advice combined. The R353Q genotype and the levels of FVIIc, FVIIag, FVIIa, PC, and TG at baseline and after 6 months were determined. Diet interention was followed by a significant reduction of 5.1% in the levels of FVIIag and 2.4 mU/ml in FVIIa (95% CI −7.4, −2.9, and −3.8, −1.1, respectively) (both p<0.001) compared to the no diet group, independent of genotype. No effects of diet intervention on FVIIc, PC or TG were observed. After VLC n-3 supplementation the TG levels were significantly reduced compared to placebo (p=0.01), whereas all FVII levels and PC remained unchanged. Dietary advice towards a “Mediterranean type” diet, but not VLC n-3 supplementation, was shown to reduce the levels of FVIIag and FVIIa after 6 months, independent of genotype. The results indicate the dietary advice to be more favourable in reducing this risk factor for CVD as compared to specific VLC n-3 supplementation.