Miracle-dz/UniFAR-FTUs huggingface dataset:
Academics' behaviors and attitudes towards open access publishing in scholarly journals

While there is significant progress with policy and a lively debate regarding the potential impact of open access publishing, few studies have examined academics' behavior and attitudes to open access publishing (OAP) in scholarly journals. This article seeks to address this gap through an international and interdisciplinary survey of academics. Issues covered include: use of and intentions regarding OAP, and perceptions regarding advantages and disadvantages of OAP, journal article publication services, peer review, and reuse. Despite reporting engagement in OAP, academics were unsure about their future intentions regarding OAP. Broadly, academics identified the potential for wider circulation as the key advantage of OAP, and were more positive about its benefits than they were negative about its disadvantages. As regards services, rigorous peer review, followed by rapid publication were most valued. Academics reported strong views on reuse of their work; they were relatively happy with noncommercial reuse, but not in favor of commercial reuse, adaptations, and inclusion in anthologies. Comparing science, technology, and medicine with arts, humanities, and social sciences showed a significant difference in attitude on a number of questions, but, in general, the effect size was small, suggesting that attitudes are relatively consistent across the academic community.
Intestinal microsporidiosis in renal transplant recipients: Prevalence, predictors of occurrence and genetic characterization

Purpose: Intestinal microsporidiosis, which occurs in immunocompromised states such as acquired immunodeficiency syndrome, has rarely been studied in patients with renal transplantation (RT) on immunosuppressive therapy. Materials and Methods: Three hundred and twenty-four consecutive RT recipients on immunosuppressive treatment and 170 healthy subjects were evaluated for intestinal microsporidiosis and other parasites by modified trichrome staining, wet mount using normal saline, iodine and polymerase chain reaction (PCR). Clinical, demographic and laboratory parameters associated with occurrence of intestinal microsporidiosis were studied using univariate and multivariate analysis. The species of microsporidia were studied using PCR-restriction fragment length polymorphism (RFLP). Patients were treated with albendazole (400 mg twice daily for 2 weeks). Results: Of 324 RT recipients initially screened, 52 were excluded from final analysis due to incomplete data. Patients with RT [n = 272, age 42 ± 12.54 years, 222 (81.6%) male] more often had microsporidiosis than healthy subjects by modified trichrome stain and PCR [n = 170, age 33.8 ± 6.7 years, 123 (72.3%) male] [16/272 (5.8%) vs. 0/170 (0%), P < 0.001]. Patients with intestinal microsporidiosis were younger (33.9 ± 8.3 years vs. 42.3 ± 12.6 years; P = 0.009), had diarrhoea more often (13/16, 81% vs. 123/256, 48%; P = 0.02), which was longer in duration (60, 32.5-105 days vs. 12, 6.2-18 days; P < 0.001) and had associated giardiasis (2/16, 12.5% vs. 2/256, 0.8%; P = 0.018). Younger age, presence of diarrhoea and associated giardiasis were significant on multivariate analysis. Enterocytozoon bieneusi was detected in 15/16 (93%) patients with intestinal microsporidiosis. Conclusion: Intestinal microsporidiosis occurs frequently in patients with RT on immunosuppressive treatment, particularly among younger patients with longer diarrhoea duration and associated giardiasis. E. bieneusi is the major species identified among these patients.
Instantaneous ego-motion estimation using Doppler radar

The growing use of Doppler radars in the automotive field and the constantly increasing measurement accuracy open new possibilities for estimating the motion of the ego-vehicle. The following paper presents a robust and self-contained algorithm to instantly determine the velocity and yaw rate of the ego-vehicle. The algorithm is based on the received reflections (targets) of a single measurement cycle. It analyzes the distribution of their radial velocities over the azimuth angle. The algorithm does not require any preprocessing steps such as clustering or clutter suppression. Storage of history and data association is avoided. As an additional benefit, all targets are instantly labeled as stationary or non-stationary.
Expression of the Duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium

The expression of chemokine binding sites on the endothelial cells of venules in inflamed synovia was examined and whether the Duffy antigen/receptor for chemokines (DARC) was involved. Insitu binding assays were performed to determine the expression of chemokine binding sites from rheumatoid (n=10) and non‐rheumatoid (n=10) synovia. The expression of DARC protein and mRNA was examined by immunohistochemistry and northern blotting. The involvement of DARC in chemokine binding was studied by incubating sections with blocking antibodies to DARC (Fy3and 6), to find out if these reduced 125I‐IL‐8 binding. Binding of radiolabelled chemokines IL‐8, RANTES, MCP‐1, but not MIP‐1α, was found on venular endothelial cells in inflamed synovia from both rheumatoid and non‐rheumatoid patients. Excess homologous unlabelled chemokine displaced binding and excess unlabelled RANTES could displace radiolabelled IL‐8 binding. DARC protein expression was demonstrated on venular endothelial cells in all samples and DARC mRNA could be detected in extracts from synovia. There was downregulation of DARC protein and mRNA in rheumatoid samples. Binding of IL‐8 to both rheumatoid and non‐rheumatoid synovia was significantly reduced in the presence of anti‐DARC Fy3 and Fy6 monoclonal antibodies. These findings show the expression of a multispecific chemokine binding site on the inflamed synovial endothelium, with evidence for involvement of DARC. This suggests a potential role for DARC in the inflammatory processes involved in synovitis. Copyright © 2002 John Wiley & Sons, Ltd.
Retinoic acid disrupts the Golgi apparatus and increases the cytosolic routing of specific protein toxins

All-trans retinoic acid can specifically increase receptor mediated intoxication of ricin A chain immunotoxins more than 10,000 times, whereas fluid phase endocytosis of ricin A chain alone or ricin A chain immunotoxins was not influenced by retinoic acid. The immunotoxin activation by retinoic acid does not require RNA or protein synthesis and is not a consequence of increased receptor binding of the immunotoxin. Vitamin D3 and thyroid hormone T3, that activate retinoic acid receptor (RAR) cognates, forming heterodimers with retinoid X receptor (RXR), do not affect the potency of immunotoxins. Among other retinoids tested, 13-cis retinoic acid, which binds neither RAR nor RXR, also increases the potency of the ricin A chain immunotoxin. Therefore, retinoic acid receptor activation does not appear to be necessary for immunotoxin activity. Retinoic acid potentiation of immunotoxins is prevented by brefeldin A (BFA) indicating that in the presence of retinoic acid, the immunotoxin is efficiently routed through the Golgi apparatus en route to the cytoplasm. Directly examining cells with a monoclonal antibody (Mab) against mannosidase II, a Golgi apparatus marker enzyme, demonstrates that the Golgi apparatus changes upon treatment with retinoic acid from a perinuclear network to a diffuse aggregate. Within 60 min after removal of retinoic acid the cell reassembles the perinuclear Golgi network indistinguishable with that of normal control cells. C6-NBD-ceramide, a vital stain for the Golgi apparatus, shows that retinoic acid prevents the fluorescent staining of the Golgi apparatus and eliminates fluorescence of C6-NBD-ceramide prestained Golgi apparatus. Electron microscopy of retinoic acid-treated cells demonstrates the specific absence of any normal looking Golgi apparatus and a perinuclear vacuolar structure very similar to that seen in monensin-treated cells. This vacuolization disappears after removal of the retinoic acid and a perinuclear Golgi stacking reappears. These results indicate that retinoic acid alters intracellular routing, probably through the Golgi apparatus, potentiating immunotoxin activity indepedently of new gene expression. Retinoic acid appears to be a new reagent to manipulate the Golgi apparatus and intracellular traffic. As retinoic acid and immunotoxins are both in clinical trials for cancer therapy, their combined activity in vivo would be interesting to examine.
DNN-Based Feature Extraction for Conflict Intensity Estimation From Speech

Over past few years, there has been an increasing need to extract nonlinguistic information from audio sources. This trend has created a new area in speech technology known as computational paralinguistics. A task belonging to this area is to estimate the intensity of conflicts arising in speech recordings, based only on the audio information. It was shown that the human comprehension of conflict intensity is closely related to speaker overlap; that is, when multiple persons are speaking at the same time. This type of information can also aid automated conflict intensity estimation. In this study, we propose a simple, DNN-based feature extraction step, and show that this approach is superior to those introduced in the literature so far: By combining our results with an efficient greedy feature selection algorithm, we were able to outperform all previous results on the SSPNet conflict dataset, achieving a correlation coefficient of 0.856 on the test set.
Near-Death Experiences and the Mind-Body Relationship: A Systems-Theoretical Perspective

In this paper I support the view that NDEs provide empirical sup- port for mind-body substance dualism and argue that a systems-theoretical an- alysis of the evidence is required to obtain valid insights into the nature of the mind as a substantial object existing in addition to the body. Without such an approach, systems phenomena such as property emergence and property mask- ing could lead to mischaracterization of both the nature of the mind itself and the ways in which the mind and body work together holistically. Applying a systems-theoretical perspective, I show that some psychic abilities are emergent capacities of the mind-body system, that ordinary faculties such as emotional perceptiveness can be understood within the same framework as extraordinary faculties such as telepathy, and that NDE evidence favors a naturalistic form of Substance Dualism.
Hyperintense Carotid Plaque on T1-Weighted Turbo-Field Echo MRI in Symptomatic Patients with Low-Grade Carotid Stenosis and Carotid Occlusion

Background: In addition to stenosis grading, magnetic resonance imaging (MRI) may provide valuable information about plaque ‘status’, e.g. hyperintense vulnerable carotid plaque, associated with higher morbidity and mortality. In the present study, we investigated the prevalence, clinical and radiological correlates of hyperintense carotid plaques on T1-weighted turbo-field echo (T1w-TFE) MRI in patients with ischemic symptoms. Methods: A total of 153 patients presenting with transient ischemic attack or ischemic infarct, studied with contrast-enhanced magnetic resonance angiography (CEMRA), were retrospectively examined. Stenosis grade was obtained from CEMRA images, presence or absence of hyperintense carotid plaque from T1w-TFE MRI. Stenosis grade and baseline characteristics were compared between patients with and without a hyperintense plaque. Results: Twenty-eight patients (18%) showed one or more hyperintense internal carotid (ICA) plaques. Hyperintense plaques were found in patients with <50% stenosis (6 of 158 ICAs), 50–70% stenosis (4 of 11), >70% stenosis (14 of 74) and carotid occlusion (4 of 28). Presence of hyperintense plaque was associated with older age (70 vs. 62 years; p < 0.05), higher prevalence of cardiac disease (61 vs. 28%; p < 0.01), ischemic infarct as presenting symptom (37 vs. 14%; p < 0.01), ischemic cerebral lesions on MRI (63 vs. 32%; p < 0.01), and the ICA on the patients’ symptomatic side (70 vs. 42%; p < 0.01). Conclusions: More than one third of patients with 50–70% stenosis present with a hyperintense plaque. This subgroup of patients could in the future possibly benefit from more aggressive medicinal therapy or revascularization.
Insect ion transport peptides are derived from alternatively spliced genes and differentially expressed in the central and peripheral nervous system

SUMMARY Insect ionic and fluid homeostasis relies upon the Malpighian tubules (MT) and different hindgut compartments. Primary urine formed in MTs is finally modified by ion, solute and water reabsorptive processes primarily in the hindgut under the control of several large peptide hormones. One of these, the ion transport peptide (ITP), is a chloride transport-stimulating and acid secretion-inhibiting hormone similar to crustacean hyperglycaemic hormones (CHHs). In locusts, moths and fruit flies, ITP together with the slightly longer ITPL isoforms, inactive in hindgut bioassays, arise by alternative splicing from very similar itp genes. ITP and ITPL are differentially distributed in (1) pars lateralis/retrocerebral complex neurosecretory cells (NSCs) containing both splice forms, (2) interneurons with either one of the splice forms, (3) hindgut-innervating abdominal ITP neurons (in Drosophila only), and (4) intrinsic, putative sensory NSCs in peripheral neurohaemal perisympathetic/perivisceral organs or transverse nerves (usually containing ITPL). Both splice forms occur as hormones released into the haemolymph in response to feeding or stress stimuli. ITPL mainly released from the peripheral NSCs is discussed as a competitive inhibitor (as established in vitro) of ITP action on yet to be identified hindgut ITP receptors. Furthermore, some evidence has been provided for possible ecdysis-related functions of ITP and/or ITPL in moths. The comparative data on the highly similar gene, precursor and primary structures and similar differential distributions in insect and crustacean NSCs suggest that CHH/ITP and ITPL neuropeptide-producing cells and their gene products share common phylogenetic ancestry.
TGF-β Converts Apoptotic Stimuli into the Signal for Th9 Differentiation

Naturally arising CD4+CD25+FoxP3+ regulatory T cells (nTregs) have an essential role in maintenance of immune homeostasis and peripheral tolerance. Previously, we reported that conventional CD4+ and CD8+ T cells undergo p53-induced CD28-dependent apoptosis (PICA) when stimulated with a combination of immobilized anti-CD3 and anti-CD28 Abs, whereas nTregs expand robustly under the same conditions, suggesting that there is a differential survival mechanism against PICA between conventional T cells and nTregs. In this study, we demonstrate that TGF-β signaling is required for nTregs to survive PICA. Conversely, when an active form of exogenous TGF-β is present, conventional T cells become resistant to PICA and undergo robust expansion instead of apoptosis, with reduction of the proapoptotic protein Bim and FoxO3a. A substantial fraction of PICA-resistant T cells expressed IL-9 (TH9 cells). Moreover, the presence of IL-6 along with TGF-β led to the generation of TH17 cells from conventional T cells. Together, the data demonstrate a novel role for TGF-β in the homeostasis of regulatory T cells and effector T cell differentiation and expansion.
Nutrition for endurance sports: Marathon, triathlon, and road cycling

Abstract Endurance sports are increasing in popularity and athletes at all levels are looking for ways to optimize their performance by training and nutrition. For endurance exercise lasting 30 min or more, the most likely contributors to fatigue are dehydration and carbohydrate depletion, whereas gastrointestinal problems, hyperthermia, and hyponatraemia can reduce endurance exercise performance and are potentially health threatening, especially in longer events (>4 h). Although high muscle glycogen concentrations at the start may be beneficial for endurance exercise, this does not necessarily have to be achieved by the traditional supercompensation protocol. An individualized nutritional strategy can be developed that aims to deliver carbohydrate to the working muscle at a rate that is dependent on the absolute exercise intensity as well as the duration of the event. Endurance athletes should attempt to minimize dehydration and limit body mass losses through sweating to 2–3% of body mass. Gastrointestinal problems occur frequently, especially in long-distance races. Problems seem to be highly individual and perhaps genetically determined but may also be related to the intake of highly concentrated carbohydrate solutions, hyperosmotic drinks, as well as the intake of fibre, fat, and protein. Hyponatraemia has occasionally been reported, especially among slower competitors with very high intakes of water or other low sodium drinks. Here I provide a comprehensive overview of recent research findings and suggest several new guidelines for the endurance athlete on the basis of this. These guidelines are more detailed and allow a more individualized approach.
The Rate of Beneficial Mutations Surfing on the Wave of a Range Expansion

Many theoretical and experimental studies suggest that range expansions can have severe consequences for the gene pool of the expanding population. Due to strongly enhanced genetic drift at the advancing frontier, neutral and weakly deleterious mutations can reach large frequencies in the newly colonized regions, as if they were surfing the front of the range expansion. These findings raise the question of how frequently beneficial mutations successfully surf at shifting range margins, thereby promoting adaptation towards a range-expansion phenotype. Here, we use individual-based simulations to study the surfing statistics of recurrent beneficial mutations on wave-like range expansions in linear habitats. We show that the rate of surfing depends on two strongly antagonistic factors, the probability of surfing given the spatial location of a novel mutation and the rate of occurrence of mutations at that location. The surfing probability strongly increases towards the tip of the wave. Novel mutations are unlikely to surf unless they enjoy a spatial head start compared to the bulk of the population. The needed head start is shown to be proportional to the inverse fitness of the mutant type, and only weakly dependent on the carrying capacity. The precise location dependence of surfing probabilities is derived from the non-extinction probability of a branching process within a moving field of growth rates. The second factor is the mutation occurrence which strongly decreases towards the tip of the wave. Thus, most successful mutations arise at an intermediate position in the front of the wave. We present an analytic theory for the tradeoff between these factors that allows to predict how frequently substitutions by beneficial mutations occur at invasion fronts. We find that small amounts of genetic drift increase the fixation rate of beneficial mutations at the advancing front, and thus could be important for adaptation during species invasions.
Learning Marginalization through Regression for Hand Orientation Inference

We present a novel marginalization method for multilayered Random Forest based hand orientation regression. The proposed model is composed of two layers, where the first layer consists of a marginalization weights regressor while the second layer contains expert regressors trained on subsets of our hand orientation dataset. We use a latent variable space to divide our dataset into subsets. Each expert regressor gives a posterior probability for assigning a given latent variable to the input data. Our main contribution comes from the regression based marginalization of these posterior probabilities. We use a Kullback-Leibler divergence based optimization for estimating the weights that are used to train our marginalization weights regressor. In comparison to the state-of-the-art of both hand orientation inference and multi-layered Random Forest marginalization, our proposed method proves to be more robust.
Correlation between the clinico radiological heterogeneity and the immune-inflammatory profiles in pediatric patients with neurocysticercosis from a tertiary referral centre.

INTRODUCTION Neurocysticercosis (NCC) is the leading cause of epilepsy in developing world. Cysticercal lesions develop in brain depending upon a combination of host immune-inflammatory response, mainly mediated by cytokines produced by cysticercal antigens. AIM AND OBJECTIVES To correlate between MRI findings and levels of Th1/Th2 cytokines present in sera of children clinically suspected of NCC with generalized or partial seizure. MATERIAL AND METHODS Fifty children presenting with history of seizures and/or mass effects and/or hydrocephalous, with a diagnosis of NCC based on the clinical and radiological profile were included. Antibody (IgM) for NCC and Th1/Th2 cytokine response (TNF-α, IL-2/and IL-6) detection was done on sera from all the patients following manufacturer's instructions. RESULTS Out of 50 cases, 10 presented with acute symptoms of NCC with an immunological response of a predominance of pro-inflammatory cytokines (IL-2: 8, TNF-α: 2). High IL-6 was found in 40 children indicating an active lesion with chronic granulomas suggestive of parasitic destruction and persisting presentation with seizures. However, the levels of IL-6 differed with values lower in patients with inactive (calcified lesions) forms of NCC. A significant proportion (43 of 50 cases) had negative serology, probably because of the waning of antibody response months or years after the parasites die. CONCLUSION Parasite maintains equilibrium with host immune response in early infection, a mild Th1 response is provoked; but later this equilibrium is disturbed toward Th2 response that leads to parasite destruction. Number or stage of the parasites along with immunegenetic aspects may explain the pleomorphic and unpredictable course of NCC.
FOIL it! Find One mismatch between Image and Language caption

In this paper, we aim to understand whether current language and vision (LaVi) models truly grasp the interaction between the two modalities. To this end, we propose an extension of the MS-COCO dataset, FOIL-COCO, which associates images with both correct and ‘foil’ captions, that is, descriptions of the image that are highly similar to the original ones, but contain one single mistake (‘foil word’). We show that current LaVi models fall into the traps of this data and perform badly on three tasks: a) caption classification (correct vs. foil); b) foil word detection; c) foil word correction. Humans, in contrast, have near-perfect performance on those tasks. We demonstrate that merely utilising language cues is not enough to model FOIL-COCO and that it challenges the state-of-the-art by requiring a fine-grained understanding of the relation between text and image.
Saponins and their potential role in diabetes mellitus

Diabetes Mellitus (DM) is a chronic metabolic disorder characterized by an increase in the serum blood glucose levels. DM resulted from defects in insulin secretion, action, or both of them. The chronic hyperglycemia resulted from diabetes can lead to irreversible damage, dysfunction and failure of various organs. Glycosidic compounds namely, saponins, are shown to have potential therapeutic benefits and are theorized as an alternative medication in decreasing serum blood glucose level in patients they suffering from diabetes. This review article aimed to elucidate the antidiabetic activity of saponins as well as showed their merit that makes them ideal for antidiabetic remediation.