Miracle-dz/UniFAR-FTUs huggingface dataset:
Occlusion child derived from natural latex for amblyopia treatment

Natural latex has been used with success in the reconstructions of the esophagus, of the abdominal wall and of the pericardium of animals, as a device to treat obesity and in inner sole with control of the plantar pressure for the diabetic foot. This article presents a new applicability proposal of the latex in patients with tendency to develop amblyopia, a visual acuity deficiency, in this sense it is idealized a contact lens of natural latex for total and gradual occlusion of the eye as new tool to treat such disease. Therefore, it is intended to develop a product that accomplishes the occlusion of the eye destined to children, with low cost and high effectiveness and with larger acceptance degree on the part of the patient with a smaller indisposition and trauma than caused it by the lid.
Stress in parents of adopted children

Stress associated with adoptive parenthood was studied in a sample of parents of 104 children below the age of 12 adopted several years before. Most of the children were adopted when they were babies, all were adopted through national adoption programs and very few matched a profile of initial adversity or of special needs. High correlations were found between mothers' and fathers' stress scores, which were in some aspects similar to, and in others lower than, that of normative data. The hierarchical regression analysis on the stress experienced by the mothers showed that both the features of children and of parents, as well as features concerning the use of support resources, are significantly predictive of stress scores for adoptive parenthood.
Na+ transport across rumen epithelium of hay‐fed sheep is acutely stimulated by the peptide IGF‐1 in vitro

An energy‐rich diet leads to enhanced ruminal Na+ absorption, which is associated with elevated plasma insulin‐like growth factor 1 (IGF‐1) levels and an increased number of IGF‐1 receptors in rumen papillae. This study examined the in vitro effect of IGF‐1 on Na+ transport across the rumen epithelium of hay‐fed sheep, in which the IGF‐1 concentration in plasma is lower than in concentrate‐fed animals. At concentrations ranging from 20 to 100 μg l−1, serosal LR3‐IGF‐1, a recombinant analogue of IGF‐1, rapidly (within 30 min) stimulated the mucosal‐to‐serosal Na+ flux (JmsNa) and consequently the net Na+ flux (JnetNa). Compared with controls, JnetNa increased by about 60% (P < 0.05) following the serosal application of LR3‐IGF‐1 (20 μg l−1). The IGF‐1‐induced increment of JmsNa and JnetNa was inhibited by mucosal amiloride (1 mmol l−1). Neither IGF‐1 nor amiloride altered tissue conductance or the short‐circuit current of the isolated rumen epithelium. These data support the assumption that the stimulating effect of serosally applied IGF‐1 on Na+ transport across the rumen epithelium is mediated by Na+–H+ exchange (NHE). A further study was performed with cultured rumen epithelial cells and a fluorescent probe (BCECF) to estimate the rate of pHi recovery after acid loading. The pHi of isolated rumen epithelial cells was 6.43 ± 0.15 after butyrate loading and recovered by 0.26 ± 0.02 pH units (15 min)−1. Application of LR3‐IGF‐1 (20 μg l−1) significantly increased the rate of pHi recovery to 0.33 ± 0.02 pH units (15 min)−1. Amiloride administration reduced the recovery rate in both control and IGF‐1‐stimulated cells. These results show, for the first time, that an acute effect of IGF‐1 on Na+ absorption across rumen epithelium results from increased NHE activity. Insulin‐like growth factor 1 is thus important for the fast functional adaptation of ruminal Na+ transport via NHE.
A Life-Cycle Model with Ambiguous Survival Beliefs

Based on a cognitive notion of neo-additive capacities reflecting likelihood insensitivity with respect to survival chances, we construct a Choquet Bayesian learning model over the life-cycle that generates a motivational notion of neo-additive survival beliefs expressing ambiguity attitudes. We embed these neo-additive survival beliefs as decision weights in a Choquet expected utility life-cycle consumption model and calibrate it with data on subjective survival beliefs from the Health and Retirement Study. Our quantitative analysis shows that agents with calibrated neo-additive survival beliefs (i) save less than originally planned, (ii) exhibit undersaving at younger ages, and (iii) hold larger amounts of assets in old age than their rational expectations counterparts who correctly assess their survival chances. Our neo-additive life-cycle model can therefore simultaneously accommodate three important empirical findings on household saving behavior.
Success Despite the Image

Abstract College athletics are at the forefront of higher education. Consequently, student-athletes are visible figures on campus. Given this visibility, coupled with the overwhelmingly negative characterizations of student-athletes, the objective of this paper is to examine the extent to which images (both positive and negative) affect a Black student-athlete's academic experience on campus. Utilizing Scheurich and Young's (1997) four levels of racism schema, the academic experiences of 17 successful Black student-athletes at Division I institutions on the West Coast are chronicled and analyzed. The participants were selected not only because of their success in their respective sport but more importantly, because they demonstrated success in the classroom. The primary research questions guiding the study are: How do academically successful African American male student-athletes experience and perceive their academic journey amidst negative characterizations? Can student-athletes' racialized incidences subsequently be classified according to the four levels of racism schema? While the participants were accomplished students, all had experienced attacks on their intellect from a variety of college personnel including faculty, academic counselors, classmates, and teammates; attacks they felt were consequences of the negative images of Black student-athletes and nothing they had personally created for themselves. The implications of these findings should be discussed among coaches, faculty, student affairs leaders, and others who frequently interact with student-athletes and are committed to creating more equitable educational environments for all students.
Neurons of the olfactory epithelium in adult rats contain vimentin

In the developing nervous system, the intermediate filament protein vimentin is found in the proliferating neuroepithelium and neural crest. As development proceeds, postmitotic neurons cease vimentin expression and neurofilament proteins begin to accumulate. We have shown that olfactory receptor neurons deviate from the general pattern of neuronal intermediate filament expression, in that they continue to express vimentin or a highly vimentin-like protein rather than neurofilament proteins in the adult rat. With light-microscopic immunohistochemistry, three independently derived antibodies to vimentin label all portions of the primary olfactory projection, including the sensory neuron cell bodies in the olfactory epithelium, the fascicles of the olfactory nerve, and their axonal arbors in the glomeruli of the olfactory bulb. In contrast, anti-neurofilament antisera stain only rare scattered receptor cells and a small number of axons in the olfactory nerve. Electron-microscopic immunohistochemistry shows dense staining of olfactory axons with anti-vimentin. The vimentin-like immunoreactive material in the olfactory nerve layer was characterized by SDS-PAGE and by immunoblotting. On immunoblots of homogenates of the olfactory nerve, the anti-vimentin monoclonal antibody SBV-21 (Blose et al., 1984) stains only a single protein of Mr = 55 kDa. This band comigrates with vimentin in crude cytoskeletal material from the neonatal rat brain prepared according to the method of Dahl et al. (1981). SBV-21 does not stain neurofilament triplet proteins or glial fibrillary acidic protein, which are also present in these blots. These results demonstrate that the vast majority of olfactory receptor neurons and their axons contain vimentin or a protein of similar immunological character and electrophoretic mobility, while identifiable expression of neurofilament proteins is confined to a very small subpopulation. Hence, the switch in intermediate filament proteins that normally accompanies neuronal maturation is arrested in most olfactory neurons, and a “juvenile” biochemical marker is retained. This population of neurons is also unique among mammalian neurons in several other respects, including that olfactory neurons die during normal adult life or following injury and then are replaced from a proliferating pool of stem cells.
Achieving remission with venlafaxine and fluoxetine in major depression: its relationship to anxiety symptoms

Venlafaxine, a serotonin and norepinephrine reuptake inhibitor (SNRI), produces significantly higher remission rates in depressed patients than do the selective serotonin reuptake inhibitors (SSRIs). In this analysis of pooled data, we explored the relationship between differences in treatment efficacy, early improvement of symptoms, and severity of baseline anxiety in depressed patients treated with either venlafaxine or fluoxetine.
Stress in the offshore oil and gas exploration and production industries: An organizational approach to stress control

Many researchers have pointed out the limitations of stress management strategies which aim solely to help the individual employee cope with stress in the work environment. In this study a stress audit approach to stress control was used to identify sources of stress which might be either reduced or eliminated by organizational change strategies. Three hundred and ten males (92 per cent British) on 97 installations working in the UK offshore oil and gas exploration and production industries took part in a stress audit. By using interview (N = 50) and questionnaire techniques, personnel were monitored over an 18-month period. Factor analysis and multiple regression analyses were used to identify sources of negative stress in the offshore environment. In this article, some of the stressors associated with job dissatisfaction are discussed and a variety of methods, including work redesign, are recommended as stress control strategies.
Presymptomatic prediction of preeclampsia with angiogenic factors, in high risk pregnant women

Introduction: The aim of this study was to investigate the value of placental growth factor (PLGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and sFlt-1/PLGF ratio, in predicting symptomatic preeclampsia (PE). Methods: A prospective longitudinal study was carried out on 71 high risk preeclamptic women cohort. All of them had normal blood pressure level (≤140/90 mmHg) at the time of enrolment, 26.8 ± 1.5 weeks. Maternal blood was collected and plasma was stored in a freezer at −80 °C. PE was defined according to the National High Blood Pressure Education Program Working Group Criteria. Accuracy of angiogenic factors in predicting PE was evaluated using Receiver-operating characteristics. Results: Maternal plasma concentrations of PLGF and sFlt-1 were able to predict PE (0.90, p < 001; 0.78, p = 0.003, area under the curve, respectively) but the sFlt-1/PLGF ratio presented the best prediction potential over the others (0.95, area under the curve, p < 0.001). Conclusion: All angiogenesis factors were effective biomarkers in predicting PE during the second trimester, before the clinical onset of PE.
Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy

Tumor cells are particularly dependent on NAD+ due to higher rates of metabolism, DNA synthesis and repair. Nicotinamide phosphoribosyltransferase inhibitors (NAMPTis) inhibit NAD+ biosynthesis and represent promising new anti-cancer agents. However, clinical efficacy has been limited by toxicities demonstrating the need for drug combinations to broaden the therapeutic index. One potential combination involves niacin/NAMPTi co-administration. Niacin can rescue NAD+ biosynthesis through a parallel pathway that depends on nicotinic acid phosphoribosyltransferase (NAPRT) expression. Most normal tissues express NAPRT while a significant proportion of malignant cells do not, providing a possible selection marker for patients to achieve NAMPTi efficacy while minimizing toxicities. Here we identify and validate a novel highly NAPRT-specific monoclonal antibody (3C6D2) that detects functional NAPRT in paraffin embedded tissue sections by immunohistochemistry (IHC). NAPRT detection by 3C6D2 coincides with the ability of niacin to rescue cells from NAMPTi induced cytotoxicity in cell lines and animal xenograft models. 3C6D2 binds to an epitope that is unique to NAPRT among phosphoribosyltransferases. In a series of primary tumor samples from lung and brain cancer patients, we demonstrate that >70 % of human small cell lung carcinomas, glioblastomas and oligodendrogliomas lack NAPRT identifying them as potentially suitable indications for the NAMPT/niacin combination.
On the power of quantum fingerprinting

In the simultaneous message model, two parties holding <i>n</i>-bit integers <i>x,y</i> send messages to a third party, the <i>referee</i>, enabling him to compute a boolean function <i>f(x,y)</i>. Buhrman et al [3] proved the remarkable result that, when <i>f</i> is the equality function, the referee can solve this problem by comparing short "quantum fingerprints" sent by the two parties, i.e., there exists a quantum protocol using only <i>O</i>(log <i>n</i>) bits. This is in contrast to the well-known classical case for which Ω(<i>n</i><sup>1/2</sup>) bits are provably necessary for the same problem even with randomization. In this paper we show that short quantum fingerprints can be used to solve the problem for a much larger class of functions. Let <i>R</i><sup><? par line>,<i>pub</i></sup>(<i>f</i>) denote the number of bits needed in the classical case, assuming in addition a common sequence of random bits is known to all parties (the <i>public coin</i> model). We prove that, if <i>R</i><sup><? par line>,<i>pub</i></sup>(<i>f</i>)=<i>O</i>(1), then there exists a quantum protocol for <i>f</i> using only <i>O</i>(log <i>n</i>) bits. As an application we show that <i>O</i>(log <i>n</i>) quantum bits suffice for the bounded Hamming distance function, defined by <i>f(x,y)</i>=1 if and only if <i>x</i> and <i>y</i> have a constant Hamming distance <i>d</i> or less.
Predictive Biomarkers and Personalized Medicine Novel Chemosensitive Single-Nucleotide Polymorphism Markers to Targeted Regimens in Metastatic Colorectal Cancer

Purpose: Methods for predicting individual responsiveness to targeted chemotherapy are urgently needed, considering the frequent resistance and extremely high cost. Experimental Design: A chemosensitive single-nucleotide polymorphism (SNP) discovery schema is presented that utilizes (i) genome-wide SNP screening with a human SNP array and an in vitro chemosensitivity assay in 118 colorectal cancers, (ii) clinical association analysis in the other 98 patients who had received chemotherapy for metastatic cancer, and (iii) biological utility assessment using cell viability assays of transfected colorectal cancer (CRC) cells. Results: Nine SNPs related to bevacizumab and cetuximab regimen sensitivity were chosen during screening. Overall responses for bevacizumab regimens revealed that patients carrying the TT genotype at ANXA11 rs1049550 or at least one G allele at LINS1 rs11247226 seemed greater chemosensitive than those carrying at least one C allele or the AA genotype, respectively (P < 0.05). For cetuximab regimens, patients carrying the GG genotype at DFNB31 rs2274159 or LIFR rs3729740 seemed greater chemosensitive than those carrying at least one A allele (P1⁄4 0.025 and P1⁄4 0.07). Cytotoxicity analyses showed that all RKO and HCT116 CRC clones transfected with the G allele at LIFR rs3729740 and the C allele at ISX rs361863 were more sensitive to cetuximab regimens than those with the A and T allele, respectively (P 0.001–0.024). Conclusions: Chemosensitive SNP markers were identified using a novel three-step process. The candidate marker LIFR rs3729740 and possibly ISX rs361863 will hopefully predict responsive patients to cetuximab regimens, although further validation is needed in large cohorts. Clin Cancer Res; 17(5);
Use of Roche AMPLICOR Mycobacterium tuberculosis PCR in Early Diagnosis of Tuberculous Meningitis

ABSTRACT Several nucleic acid-based amplification tests are available for the detection of Mycobacterium tuberculosis, but few data are available on their use in the diagnosis of tuberculous meningitis (TBM). We performed a prospective study to assess the Roche AMPLICORMycobacterium tuberculosis PCR test (TB AMPLICOR) for use in the diagnosis of TBM and compared it with direct Ziehl-Neelsen staining of smears, radiometric culture for M. tuberculosis, and clinical and cerebrospinal fluid (CSF) findings. Eighty-three CSF specimens collected from 69 patients with suspected meningitis in South Africa were tested by TB AMPLICOR. On the basis of clinical and laboratory findings, 40 of these patients were treated for TBM and 29 patients were not treated for TBM. Ten CSF samples from 10 patients were positive by TB AMPLICOR. Seven of these 10 patients were classified as having definite TBM, 2 were classified as having probable TBM, and 1 was classified as having possible TBM. The sensitivity of TB AMPLICOR for detecting cases of definite and probable TBM in patients from whom CSF specimens had been collected less than 10 days into antituberculosis treatment was 60.0%. Specimens from all 29 patients not treated for TBM were negative by the TB AMPLICOR, giving a 100% specificity. TB AMPLICOR is therefore more sensitive than the combination of Ziehl-Neelsen staining of smears and radiometric culture for M. tuberculosis and is a rapid and highly specific diagnostic test for TBM.
Infants' delayed recognition memory for colour and form

Delayed recognition memory was investigated in 5- and 9-week-old infants after extensive familiarization to a visual stimulus. Both age groups were found to demonstrate memory for colour and form information after a 24 hour delay. In addition the location of testing, relative to the location of familiarization, was found to influence the apparent strength of memory, while there was no effect of sex nor evidence of additivity of stimulus dimensions.
Histamine release by contrast media.

The blood draining organs with a high histamine content was sampled and elevation of plasma histamine was found to result from injections of certain contrast media. All methylglucamine contrast media tested to date (acetrizoate, diatrizoate, and iodipamide) produced such elevations. Methylglucamine chloride also caused elevation of plasma histamine. Some “allergic” reactions to contrast media may be explained on this basis.
The Effects of Headache on Clinical Measures of Neurocognitive Function

Objective:To examine effects of preseason baseline headache and posttraumatic headache (PTH) on neurocognitive function. Design:Retrospective repeated measures study with headache groups formed regarding baseline headache score (0 = negative headache; 1-6 = positive headache) and day 1 postinjury headache score (0 = no headache; 1-2 = mild headache; 3-6 = moderate-severe headache). Setting:Clinical athletic training setting and sports medicine research laboratory. Participants:High-school and collegiate athletes with a concussion. Independent Variables:Preseason baseline headache, PTH, test-day. Main Outcome Measures:A Graded Symptom Checklist (GSC) was used to assess symptoms. The Automated Neuropsychological Assessment Metrics (ANAM) and the Standardized Assessment of Concussion (SAC) were used to assess neuropsychological function and mental status. The Balance Error Scoring System (BESS) was used to assess postural stability. Results:Both baseline headache groups displayed a higher symptom endorsement and higher symptom severity at day 1 postinjury and improved by day 7 postinjury. The positive headache group reported an even greater increase in symptom severity and presence (P < 0.05). ANAM revealed deficits in both groups 1 day postinjury. All PTH headache groups displayed a difference in symptom number and severity with the increase being magnified by headache severity (P < 0.05). Individuals reporting moderate-severe PTH displayed increased deficits subacutely but improved by 5-7 days postinjury on overall neuropsychological performance, reaction time, and working memory (P < 0.05). Deficits were observed for all ANAM measures except simple reaction time 1 (SRT 1) and match to sample subacutely and improved over time (P < 0.05). The SAC yielded an interaction (P < 0.05) for baseline headache. The BESS yielded no significant findings. Conclusions:Clinicians should consider headache when assessing concussion and during preseason baseline assessments because headache may affect symptom presence and other clinical measures of concussion.
Addressing Cultural Factors in Development of System Interventions

SUMMARY The purpose of this article is to address various issues concerning multicultural interventions at a system level. Diversity is presented through a different conceptual approach and specific implications for school psychological practice are addressed. In this theoretical context an alternative model of school psychological services that was developed in the Greek educational system is presented and a primary intervention program is described as a paradigm of multicultural system/community intervention. Finally, the components of a transnational approach to multicultural system/community interventions that provides the basic procedural guidelines to developing effective, culturally sensitive interventions in the school environment is proposed.
Informed consent: still a useful tool in research ethics

This article dicusses informed consent (IC): its evolution, its main challenges, and its theoretical assumptions. This process involves the interrelation of IC with the history and evolution of research ethics, and with some abuses committed in biomedical research. The article also presents the objections to IC, especially those related to its implementation in developing countries. It also approaches the epistemological problems and those related to the capacity of acting, given the background conditions in which IC is obtained. Furthermore, the article exposes the traditional justification of IC as conveyed by the Belmont Report, as well as a frequent simplification of this justification that focuses only on the deliberative aspect of IC, in which the emphasis on the autonomy or deliberation supposes an inadequate view of research subjects.
A Modified Clustering Algorithm for Fuzzy Modeling Using Fuzzy C-Regression Model

In this paper, a modified clustering algorithm for fuzzy modeling is developed to overcome the scattered hyperplane-shaped clusters using fuzzy C-regression model. A new objective function for clustering is proposed by adding an item in the optimum cost function such that the resulting clusters are continuous, as well as hyperplane-shaped. Two examples are given to show the better modeling performance of the new clustering approach than the original one