Miracle-dz/UniFAR-FTUs huggingface dataset:
Glutamate transporter‐associated anion channels adjust intracellular chloride concentrations during glial maturation

Astrocytic volume regulation and neurotransmitter uptake are critically dependent on the intracellular anion concentration, but little is known about the mechanisms controlling internal anion homeostasis in these cells. Here we used fluorescence lifetime imaging microscopy (FLIM) with the chloride‐sensitive dye MQAE to measure intracellular chloride concentrations in murine Bergmann glial cells in acute cerebellar slices. We found Bergmann glial [Cl−]int to be controlled by two opposing transport processes: chloride is actively accumulated by the Na+‐K+‐2Cl− cotransporter NKCC1, and chloride efflux through anion channels associated with excitatory amino acid transporters (EAATs) reduces [Cl−]int to values that vary upon changes in expression levels or activity of these channels. EAATs transiently form anion‐selective channels during glutamate transport, and thus represent a class of ligand‐gated anion channels. Age‐dependent upregulation of EAATs results in a developmental chloride switch from high internal chloride concentrations (51.6 ± 2.2 mM, mean ± 95% confidence interval) during early development to adult levels (35.3 ± 0.3 mM). Simultaneous blockade of EAAT1/GLAST and EAAT2/GLT‐1 increased [Cl−]int in adult glia to neonatal values. Moreover, EAAT activation by synaptic stimulations rapidly decreased [Cl−]int. Other tested chloride channels or chloride transporters do not contribute to [Cl−]int under our experimental conditions. Neither genetic removal of ClC‐2 nor pharmacological block of K+‐Cl− cotransporter change resting Bergmann glial [Cl−]int in acute cerebellar slices. We conclude that EAAT anion channels play an important and unexpected role in adjusting glial intracellular anion concentration during maturation and in response to cerebellar activity. GLIA 2017;65:388–400
Auctions versus Posted Prices in Online Markets

Auctions were very popular in the early days of internet commerce, but today online sellers mostly use posted prices. We model the choice between auctions and posted prices as a trade-off between competitive price discovery and convenience. Evidence from eBay fits the theory. We then show that the decline in auctions was not driven by compositional shifts in seller experience or items sold, but by changing seller incentives. We estimate the demand facing sellers and document falling sale probabilities and falling relative demand for auctions. Both favor posted prices; our estimates suggest the latter is more important for the auction decline. Survey evidence provides further support.
De novo Craniopharyngioma of the Fourth Ventricle: Case Report and Review of Literature

Craniopharyngiomas usually involve the sella and suprasellar space. Their occurrence in the posterior fossa without extension to the suprasellar region is uncommon with only 16 cases reported in the literature. We report a case of a primary posterior fossa craniopharyngioma that was managed by complete excision with a good recovery. Our case was unique in that the craniopharyngioma occurred in the fourth ventricle and extended downward to the level of C1, a manifestation that was reported only twice in the past. The literature on the topic is reviewed.
Personal Pornography Viewing and Sexual Satisfaction: A Quadratic Analysis

ABSTRACT Personal pornography viewing has been associated with lower sexual satisfaction in both experimental and observational research. The language used to hypothesize this relationship typically suggests that it is frequent viewing, rather than infrequent or only occasional viewing, that is responsible for any adverse effects. When the nature of the relationship between a predictor and a criterion depends on the levels of the predictor, a curvilinear relationship is indicated. Nevertheless, studies have assumed linearity in their analytical approach. Curvilinear relationships will go undetected unless they are specifically tested. This article presents results from a survey of approximately 1,500 U.S. adults. Quadratic analyses indicated a curvilinear relationship between personal pornography viewing and sexual satisfaction in the form of a predominately negative, concave downward curve. The nature of the curvilinearity did not differ as a function of participants' gender, relationship status, or religiosity. But the negative acceleration was slightly more pronounced for men than for women, for people not in a relationship than for people in a relationship, and for religious people than for nonreligious people. For all groups, negative simple slopes were present when viewing reached once a month or more. These results are correlational only. However, if an effects perspective were adopted, it would suggest that consuming pornography less than once a month has little or no impact on satisfaction, that reductions in satisfaction tend to initiate once viewing reaches once a month, and that additional increases in the frequency of viewing lead to disproportionately larger decrements in satisfaction.
Admission Heart Rate Predicts Poor Outcomes in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies

Background and Purpose— Faster heart rate predicts higher mortality in coronary heart disease and acute ischemic stroke, but its prognostic significance in intracerebral hemorrhage remains uncertain. We aimed to determine the effect of admission heart rate on clinical and imaging outcomes in patients with intracerebral hemorrhage. Methods— A post hoc pooled analysis of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT 1 and 2). Clinical outcomes were mortality and modified Rankin Scale score at 90 days; and imaging outcome was absolute growth in hematoma volume during the initial 24 hours. Patients were divided into 4 categories according to baseline heart rate (<65, 65–74, 75–84, and ≥85 bpm) and analyzed using multivariable adjusted models with the lowest heart rate group as the reference. Results— Of 3185 patients with available data, higher admission heart rate was associated with both mortality and worse modified Rankin Scale score: adjusted hazard ratio for heart rate (≥85 versus <65 bpm) 1.50 (95% confidence interval, 1.07–2.11) and adjusted odds ratio 1.33 (95% confidence interval, 1.08–1.63), respectively (both P-trend <0.05). There was no significant relationship between heart rate and absolute growth in hematoma volume (P-trend, 0.196). Conclusions— Higher admission heart rate is independently associated with death and poor functional outcome after acute intracerebral hemorrhage. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT00226096 and NCT00716079.
Zero-Shot Scene Classification for High Spatial Resolution Remote Sensing Images

Due to the rapid technological development of various sensors, a huge volume of high spatial resolution (HSR) image data can now be acquired. How to efficiently recognize the scenes from such HSR image data has become a critical task. Conventional approaches to remote sensing scene classification only utilize information from HSR images. Therefore, they always need a large amount of labeled data and cannot recognize the images from an unseen scene class without any visual sample in the labeled data. To overcome this drawback, we propose a novel approach for recognizing images from unseen scene classes, i.e., zero-shot scene classification (ZSSC). In this approach, we first use the well-known natural language process model, word2vec, to map names of seen/unseen scene classes to semantic vectors. A semantic-directed graph is then constructed over the semantic vectors for describing the relationships between unseen classes and seen classes. To transfer knowledge from the images in seen classes to those in unseen classes, we make an initial label prediction on test images by an unsupervised domain adaptation model. With the semantic-directed graph and initial prediction, a label-propagation algorithm is then developed for ZSSC. By leveraging the visual similarity among images from the same scene class, a label refinement approach based on sparse learning is used to suppress the noise in the zero-shot classification results. Experimental results show that the proposed approach significantly outperforms the state-of-the-art approaches in ZSSC.
Certificateless Provable Data Possession Scheme for Cloud-Based Smart Grid Data Management Systems

The smart grid is considered to be the next-generation power system because of its reliability, efficiency, and cost-effectiveness. In recent years, the smart grid technology has attracted a lot of attention from both academia and industry. Advances in smart grid technologies are enabling more data to be collected and analyzed in real-time for many kinds of smart grid applications. As the amount of data increases, the traditional smart grid data management system cannot provide sufficient storage and processing capacities. To address these challenges, cloud computing is being introduced into the power system and the cloud-based smart grid data management system has been proposed to better support smart grid applications. In this cloud-based system, the data are stored and analyzed by the remote cloud server according to the requirements of smart grid applications. However, the loss of physical control over the smart grid data makes it a significant challenge in ensuring the integrity of the data. Many provable data possession schemes have been proposed in the past few years. However, most of them suffer from serious security weaknesses or poor performance. We propose an efficient certificateless provable data possession (CL-PDP) scheme for cloud-based smart grid applications. Security analysis shows that the proposed scheme is provably secure in a robust security model and can satisfy several security requirements. Performance analysis demonstrates that the proposed scheme results in lower computation costs as compared to two recently proposed CL-PDP schemes.
An eigenvalue approach for the automatic scaling of unknowns in model‐based reconstructions: Application to real‐time phase‐contrast flow MRI

The purpose of this work is to develop an automatic method for the scaling of unknowns in model‐based nonlinear inverse reconstructions and to evaluate its application to real‐time phase‐contrast (RT‐PC) flow magnetic resonance imaging (MRI). Model‐based MRI reconstructions of parametric maps which describe a physical or physiological function require the solution of a nonlinear inverse problem, because the list of unknowns in the extended MRI signal equation comprises multiple functional parameters and all coil sensitivity profiles. Iterative solutions therefore rely on an appropriate scaling of unknowns to numerically balance partial derivatives and regularization terms. The scaling of unknowns emerges as a self‐adjoint and positive‐definite matrix which is expressible by its maximal eigenvalue and solved by power iterations. The proposed method is applied to RT‐PC flow MRI based on highly undersampled acquisitions. Experimental validations include numerical phantoms providing ground truth and a wide range of human studies in the ascending aorta, carotid arteries, deep veins during muscular exercise and cerebrospinal fluid during deep respiration. For RT‐PC flow MRI, model‐based reconstructions with automatic scaling not only offer velocity maps with high spatiotemporal acuity and much reduced phase noise, but also ensure fast convergence as well as accurate and precise velocities for all conditions tested, i.e. for different velocity ranges, vessel sizes and the simultaneous presence of signals with velocity aliasing. In summary, the proposed automatic scaling of unknowns in model‐based MRI reconstructions yields quantitatively reliable velocities for RT‐PC flow MRI in various experimental scenarios.
Superficial spreading melanoma: an analysis of 97 702 cases using the SEER database

Superficial spreading melanoma (SSM) is the most common type of melanoma. Large, population-based studies analyzing the incidence and survival of SSM are limited. This retrospective study was designed to evaluate demographic factors influencing the incidence and survival of SSM using a national population-based database. The United States National Cancer Institute’s Surveillance, Epidemiology, and End Results registry was used to calculate incidence and disease-specific survival trends for SSM between 1973 and 2012. Patient data were stratified according to age, sex, race, ulceration, thickness, and stage. Of 97 702 patients, 52.66% were men, 94.93% were white, and 38.92% had a primary lesion on the trunk. The overall incidence is 5.987/100 000 and is increasing with an annual percentage change (APC) of 1.42%. Incidence increases with age, peaking at 70–79 years. Men (6.68/100 00, APC: 1.78) had a significantly higher incidence than women (5.565/100 000, APC: 1.10). A total of 79.16% of SSM are less than or equal to 1 mm and 92.32% are nonulcerated. The overall 5-year survival is 95.30% and is increasing steadily. Women (hazard ratio: 0.54), ‘other’ races (hazard ratio: 0.30), those with local disease, those with thin tumors, and those without ulceration had higher survival than their counterparts (P<0.0001). The incidence of this predominantly thin melanoma subtype is on the rise, creating enhanced concern. Primary and secondary prevention techniques should consider the mortality associated with thin melanoma.
Fusarium: Molecular Diversity and Intrinsic Drug Resistance

1 CBS-KNAW Fungal Biodiversity Centre, Utrecht, the Netherlands, 2 Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, the Netherlands, 3 Directorate General of Health Services, Ministry of Health, Ibri Hospital, Ibri, Oman, 4 Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands, 5 Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands, 6 Basic Pathology Department, Federal University of Paraná State, Curitiba, Paraná, Brazil, 7 Biological Sciences Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
High tolerance of microzooplankton to ocean acidification in an Arctic coastal plankton community

Impacts of ocean acidification (OA) on marine biota have been observed in a wide range of marine systems. We used a mesocosm approach to study the response of a high Arctic coastal protozooplankton (PZP in the following) community during the post-bloom period in the Kongsfjorden (Svalbard) to direct and indirect effects of high pCO2/low pH. We found almost no direct effects of OA on PZP composition and diversity. Both, the relative shares of ciliates and heterotrophic dinoflagellates as well as the taxonomic composition of protozoans remained unaffected by changes in pCO2/pH. The different pCO2 treatments did not have any effect on food availability and phytoplankton composition and thus no indirect effects e.g. on the total carrying capacity and phenology of PZP could be observed. Our data points at a high tolerance of this Arctic PZP community to changes in pCO2/pH. Future studies on the impact of OA on plankton communities should include PZP in order to test whether the observed low sensitivity of protozoans to OA is typical for coastal communities where changes in seawater pH occur frequently.
Supplementary Methods: Tradeoffs between microbial growth phases lead to frequency-dependent and non-transitive selection

The time tsat at which growth saturates is determined by a model of resource consumption. Let R be the initial amount of resources. We assume that each strain consumes resources in proportion to its population size, for example, if the limiting resource is space. Let the yield Yi be the number of cells of strain i per unit of the resource. Therefore the resources are exhausted at time t = tsat such that
Assessment of the Ozone-Mediated Killing of Bacteria in Infected Dentine Associated with Non-Cavitated Occlusal Carious Lesions

The ability of ozone to kill micro-organisms associated with non-cavitated occlusal caries was investigated. The occlusal surfaces were treated with ozone (n = 53) or air (n = 49) for 40 s, and the underlying infected dentine was exposed. There was no significant difference between the number of bacteria recovered from the ozone-treated and the control sites (p > 0.1). Treatment of the exposed dentine with ozone resulted in a just significant (p = 0.044) reduction in bacterial counts. Ozone treatment of non-cavitated occlusal lesions for 40 s failed to significantly reduce the numbers of viable bacteria in infected dentine beneath the demineralized enamel.
Reliability of parent recall of symptom onset and timing in autism spectrum disorder

Past events are often reported as occurring more recently than they actually took place, an error called forward telescoping. This study examined whether forward telescoping was evident in parent reports of autism spectrum disorder symptom emergence and onset classification. Parents were interviewed when their child was 2–3 years old (Time 1) and approximately 6 years old (Time 2). Significant forward telescoping was found in both age of social regression and age when language milestones were achieved, but not age of language regression. The correspondence between Time 1 and Time 2 onset report was low (kappa = 0.38). Approximately one-quarter of the sample changed onset categories, most often due to parents not recalling a regression at Time 2 that they had reported at Time 1. These results challenge the use of retrospective methods in determining onset patterns.
International Journal of Information Management

Large amounts of customer data present rich business opportunities. Drawing on the privacy calculus model, this study investigates the antecedents of self-disclosure intention and self-disclosure honesty. We extend the privacy calculus model by exploring how the characteristics of service providers and the interpersonal difference of users inﬂuence privacy trade-off. An online empirical survey that involves 913 respondents was conducted. We ﬁnd that both monetary rewards and social rewards positively predict self-disclosure intention, whereas only social rewards positively predict self-disclosure honesty. Moreover, application reputation and ﬂow experience of users weaken the perceptions of privacy concern, and application compatibility and ﬂow experience strengthen the perceptions of social rewards. Our results suggest that users place more weight on social rewards than on monetary rewards. Therefore, service providers are advised to create salient and distinct social rewards. They can also adopt distinct marketing strategies based on their proﬁles and the interpersonal difference of their users. © 2016 Elsevier Ltd. All rights reserved.
Does Contralesional Hand Function After Neonatal Stroke Only Depend on Lesion Characteristics?

Background and Purpose— In children having suffered from neonatal arterial ischemic stroke, the relationship between contralesional hand performance and structural changes in brain areas remote from the infarct site was examined. Methods— Using voxel-based morphometry, we correlated contralesional gross manual dexterity assessed by the box and block test and whole-brain gray and white-matter volume changes on high-resolution magnetic resonance imaging in 37 7-year-old post–neonatal arterial ischemic stroke children. We also compared the volume of the identified structures with magnetic resonance imaging data of 10 typically developing age-matched children. Results— Areas showing the highest positive correlation with the box and block test scores were ipsilesional mediodorsal thalamus, contralesional cerebellar lobule VIIa Crus I, and ipsilesional corticospinal tract at the level of superior corona radiata, the posterior limb of the internal capsule, and the cerebral peduncle and the ipsilesional body of corpus callosum. When compared with typically developing age-matched children, post–neonatal arterial ischemic stroke children with severe contralesional hand motor deficit exhibited significant volume reductions in these structures (except the cerebellum), whereas no differences were found with those with good manual dexterity. No negative correlation was found between box and block test scores and brain areas. Conclusions— Contralesional hand performance after neonatal arterial ischemic stroke is correlated with atrophy in brain areas directly or functionally connected but anatomically remote from the infarct. Our study suggests a role of the cerebellar lobule VIIa Crus I and mediodorsal thalamus in manual dexterity. Clinical Trial Registration— URL: https://clinicaltrials.gov. Unique identifier: NCT02511249.
Colloid Administration Normalizes Resuscitation Ratio and Ameliorates “Fluid Creep”

Although colloid was a component of the original Parkland formula, it has been omitted from standard Parkland resuscitation for over 30 years. However, some burn centers use colloid as “rescue” therapy for patients who exhibit progressively increasing crystalloid requirements, a phenomenon termed “fluid creep. ” We reviewed our experience with this procedure. With Institutional Review Board approval, we reviewed all adult patients with ≥20%TBSA burns admitted from January 1, 2005, through December 31, 2007, who completed formal resuscitation. Patients were resuscitated using the Parkland formula, adjusted to maintain urine output of 30 to 50 ml/hr. Patients who required greater amounts of fluid than expected were given a combination of 5% albumin and lactated Ringer's until fluid requirements normalized. Results were expressed as an hourly ratio (I/O ratio) of fluid infusion (ml/kg/%TBSA/hr) to urine output (ml/kg/hr). Predicted values for this ratio vary for individual patients but are usually less than 0.5 to 1.0. Fifty-two patients were reviewed, of whom 26 completed resuscitation using crystalloid alone, and the remaining 26 required albumin supplementation (AR). The groups were comparable in age, gender, weight, mortality, and time between injury and admission. AR patients had larger total and full-thickness burns and more inhalation injuries. Patients managed with crystalloid alone maintained mean resuscitation ratios from 0.13 to 0.40, whereas AR patients demonstrated progressively increasing ratios to a maximum mean of 1.97, until albumin was started. Administration of albumin produced a dramatic and precipitous return of ratios to within predicted ranges throughout the remainder of resuscitation. No patient developed abdominal compartment syndrome. Measuring hourly I/O ratios is an effective means of expressing and tracking fluid requirements. The addition of colloid to Parkland resuscitation rapidly reduces hourly fluid requirements, restores normal resuscitation ratios, and ameliorates fluid creep. This practice can be applied selectively as needed using predetermined algorithms.