Miracle-dz/UniFAR-FTUs huggingface dataset:
The Structure-Phase Compositions and Mechanical Properties of Ni-Cr-Al-Based Alloy after Strong Deformation and Low-Temperature Aging

This paper presents the analysis of new results of experimental investigating of the structure-phase compositions and mechanical properties of Ni-Cr-Al-based alloy after strong deformation and low temperature aging. We empirically established the isolation of new phase at long aging at 673 K in the result of complex reaction of recrystallization and cellular precipitation. The analysis of kinetic dependence of mechanical properties testifies to strengthening influence of a new phase.
Radiolabeled novel mAb 4G1 for immunoSPECT imaging of EGFRvIII expression in preclinical glioblastoma xenografts

Epidermal growth factor receptor mutant III (EGFRvIII) is exclusively expressed in tumors, such as glioblastoma, breast cancer and hepatocellular carcinoma, but never in normal organs. Increasing evidence suggests that EGFRvIII has clinical significance in glioblastoma prognosis due to its enhanced tumorigenicity and chemo/radio resistance, thus the development of an imaging approach to early detect EGFRvIII expression with high specificity is urgently needed. To illustrate this point, we developed a novel anti-EGFRvIII monoclonal antibody 4G1 through mouse immunization, cell fusion and hybridoma screening and then confirmed its specificity and affinity by a serial of assays. Following biodistribution and small animal single-photon emission computed tomography (SPECT/CT) imaging of 125I-4G1 in EGFRvIII positive/negative tumor-bearing mice were performed and evaluated to verify the tumor accumulation of this radiotracer. The biodistribution indicated that 125I-4G1 showed prominent tumor accumulation at 24 h post-injection, which reached maximums of 11.20 ± 0.75% ID/g and 13.98 ± 0.57% ID/g in F98npEGFRvIII and U87vIII xenografts, respectively. In contrast, 125I-4G1 had lower tumor accumulation in F98npEGFR and U87MG xenografts. Small animal SPECT/CT imaging revealed that 125I-4G1 had a higher tumor uptake in EGFRvIII-positive tumors than that in EGFRvIII-negative tumors. This study demonstrates that radiolabeled 4G1 can serve as a valid probe for the imaging of EGFRvIII expression, and would be valuable into the clinical translation for the diagnosis, prognosis, guiding therapy, and therapeutic efficacy evaluation of tumors.
Prognostic factors for treatment success in patients with multidrug-resistant tuberculosis in China.

OBJECTIVE To examine the clinical outcomes and associated prognostic factors among patients with multidrug-resistant tuberculosis (MDR-TB) in China. METHODS This retrospective study involved 243 patients with MDR-TB. All patients received standard regimens containing para-amino salicylic acid (PAS) and/or cycloserine (CS). The demographic, social and clinical characteristics of patients were recorded and the patients were followed up for 24 months. RESULTS Treatment success was closely associated with young age, non-farming occupations, shorter history or smoking, normal urine results, initial MDR-TB treatment regimen, increased haemoglobin, direct bilirubin, uric acid and thyroid stimulating hormone (TSH) levels, and lower white blood cell, neutrophil and blood platelet counts (all P < 0.05). On multivariable analysis, increased haemoglobin (hazard ratio [HR] 1.019, 95%CI 1.007-1.032, P = 0.002) and TSH levels (HR 1.002, 95%CI 1.006-1.039, P = 0.008), normal urine results (HR 1.541, 95%CI 1.008-2.358, P = 0.046) and initial MDR-TB treatment regimen (HR 2.238, 95%CI 1.090-4.597, P = 0.028) were prognostic factors for treatment success in MDR-TB. CONCLUSIONS Higher haemoglobin and TSH levels, normal urine results and initial MDR-TB treatment regimen might predict successful treatment of MDR-TB.
Flammability properties of intumescent PLA including starch and lignin

The aim of this study is to evaluate the efficiency of different intumescent formulations to flame retard polylactic acid (PLA). First, the ammonium polyphosphate (APP)/pentaerythritol (PER) system is chosen because it previously demonstrated a good behavior for polyethylenic matrices. The PER is then substituted by bioresources such as lignin and starch. The flame retardant properties of the various formulations are evaluated by limiting oxygen index (LOI), UL-94, and cone calorimetry. Compared to the PLA/APP/PER composite, the materials containing lignin and starch show lower LOI values but still commercially acceptable (superior to 32%). In contrast, the UL ratings obtained for these formulations are superior to that containing PER (V0 against V2 rating). The cone calorimeter analysis confirms the formation of an intumescent structure for the “green” composites, with a final residue corresponding to 50% of the initial sample mass and also a decrease in the peak of heat release of 50%. Finally, the composition of the formulation is optimized following a mixture design methodology to maximize the quantity of bioresources. A 32% LOI value is obtained for a composite containing 60% PLA, 12% APP, and 28% starch. Copyright © 2008 John Wiley & Sons, Ltd.
Polysomnographic characteristics in patients with mucopolysaccharidoses

To evaluate the prevalence of obstructive sleep apnea (OSA) and to clarify sleep characteristics in patients with mucopolysaccharidoses (MPS), we performed overnight polysomnographic studies in 24 patients (22 males and 2 females; 3 with MPS I, 15 with MPS II, 1 with MPS III, 1 with MPS IV, and 4 with MPS VI; mean age, 10.8 ± 6.0 years; age range, 2.0–23.7 years; 2 patients ≥18 years of age). The nadir arterial oxygen saturation (SaO2) was 74.5 ± 12.3%, and the average percentage of sleep time with an SaO2 of <95% was 39.4%. The percentages of total sleep time spent in sleep stages N1, N2, N3, and R were 18.6 ± 10.8%, 50.3 ± 7.6%, 14.8 ± 8.1%, and 15.3 ± 4.6%, respectively. The respiratory disturbance index (RDI) was 21.8 ± 20.4/hr, and obstructive apnea–hypopnea index (OAHI) and central apnea index were 21.4 ± 19.9/hr and 0.4 ± 0.6/hr, respectively. The desaturation index was 17.6 ± 17.8/hr. All patients had some degree of OSA. For 22 children, the disorder was mild (OAHI 1.5–5) in 2, moderate (OAHI 5–10) in 7, and severe (OAHI > 10) in 13. Two patients with MPS II who received enzyme replacement therapy had reductions in RDI after treatment (38.9–10.8 and 3.5–2.0, respectively). The prevalence of moderate to severe OSA was 88% (21/24) in patients with MPS. The overnight polysomnography will help to determine the abnormalities of breathing during sleep more precisely and urge the clinicians to take necessary action for patients with severe manifestations. Pediatr Pulmonol. 2010;45:1205–1212. © 2010 Wiley‐Liss, Inc.
Improvement of Flux Pinning Properties of RE123 Materials by Chemical Doping

Improvement of flux pinning properties of RE123 single crystals and melt-solidified bulks was attempted by dilute doping of impurity elements to various cation sites except the Cu at the CuO2 plane. All the examined dilute doping for RE123, such as Sr to Ba-site, Lu to Y-site and Co to Cu-site in the CuO-chain, was found to increase critical current density, Jc, particularly under magnetic fields accompanying enhanced second peak effect. These results suggest that the dilute doping is universally effective for improving the critical current properties of the RE123 system independent of the doped cation sites.
Analysis of edge stresses of plain concrete pavements

The paper focus on analysis carried out for a wide range of load and slab-soil combinations, with an aim to derive unified expression on edge stresses. Edge stresses of plain concrete (PC) slabs-on-grade were computed by finite element methods using three-dimensional (3D) brick and spring elements for slab and soil, respectively. The soil as Winkler type spring model represented by elastic springs (soil–structure interaction) and their stiffness was derived from modulus of sub-grade reaction. The influence of any particular base or sub base on edge stresses was not studied here. The expression was validated with both experimental and theoretical results obtained from literature review on software.
The Selective Centrifugation Ensures a Better In Vitro Isolation of ASCs and Restores a Soft Tissue Regeneration In Vivo

Autologous fat grafting procedures in plastic surgery have been extensively used to reinforce soft tissue in congenital or acquired tissue impairments. With this background, the aim of this study is firstly to examine the impact of a selective centrifugation on existing adipose stem cells (ASCs) in terms of stemness profile maintenance and, secondly, to investigate the effect of restoring volume in reconstruction on patients affected by soft tissue damage. After centrifugation, the fat graft products were separated into two layers and subsequently examined in vitro for the expression of CD34, CD90, CD117, CD105, CD29, CD31, CD44, CD73, CD133, CD14 and CD45 markers by flow cytometry and gene expression analyses were performed for Sox2, WNT3A, END, CD44, FUT4, COLL1, CTNNB1, hbEGF, KRTLG, MMP2 and VIM genes. The results showed that in the middle-high density (MHD) layer there was a peak concentration of ASCs, compared to another layer obtained after centrifugation. Research carried out on patients under treatment for soft tissue regeneration using cells obtained from MHD layer selection will be fundamental in comparative analysis. These studies will lead to an adequate standardization of outcomes, provided that treatment is performed through cell selection. Therefore, a unique procedure in tissue reconstruction and regeneration through fat grafting is presented here.
Acute Confusional State in Elderly Patients with Hip Fracture. Identification of risk factors and intervention using a prehospital and perioperative management program Björkman Björkelund, Karin

7 ABBREVIATIONS . 8 ORIGINAL PAPERS. 9 INTRODUCTION . 10 BACKGROUND . 10 Acute Confusional State (ACS) . 10 Definition of ACS. 12 Terms and symptom profiles . 12 Etiology and underlying mechanisms of ACS. 13 Postoperative cognitive dysfunction, POCD . 13 Dementia . 14 The aging brain . 14 Cognition . 14 Elderly patients. 15 Elderly patients’ experiences of having ACS. 15 Risk factors for ACS . 15 Elderly patients with hip fracture . 16 Swedish National Hip Fracture Register . 17 Fall and fracture type . 18 ASA risk classification . 19 Anesthesia. 20 Timing of surgery . 21 Pain . 21 Hypoxemia. 22 Anemia. 22 Hypotension . 22 Dehydration and malnutrition. 23 Drugs. 23 Outcome after hip fracture . 24 Intervention studies . 25 Documentation . 26 Cognitive tests . 26 RATIONALE FOR THE THESIS . 29 AIMS. 30 METHODS . 31 Design and study description . 31 Study population . 31 Data collection. 33 Study I and II . 33 Study III. 34 Study IV. 34 Assessments in study IV. 36 Intervention in study IV. 37 DATA ANALYSIS. 40 Study I, II and IV. 40 Study III. 41 ETHICAL CONSIDERATIONS. 43 FINDINGS. 46 Study I, Factors at admission associated to 4-months outcome in elderly patients with hip fracture . 46 Study II, The influence of perioperative care and treatment on 4-months outcome in elderly patients with hip fracture. 46 Study III, The Organic Brain Syndrome (OBS) Scale: a systematic review . 54 Study IV, Reducing Acute Confusional State in elderly patients with hip fracture: a multi-factorial intervention study. 59 DISCUSSION. 63 Methodological considerations . 64 The findings of the studies . 69 Risk factors for ACS . 69 Prevalence of ACS . 70 Morbidity and mortality after ACS . 72 ACS assessment. 73 Reduction of ACS by a multi-factorial intervention program. 73 Clinical implications . 74 CONCLUSIONS. 75 FUTURE RESEARCH . 76 POPULÄRVETENSKAPLIG SAMMANFATTNING . 77 ACKNOWLEDGEMENTS. 80 REFERENCES . 82 APPENDIX I III PAPER I IV
Processor caches built using multi-level spin-transfer torque RAM cells

It has been predicted that a processor's caches could occupy as much as 90% of chip area for technology nodes from the current. In this paper, we study the use of multi-level spin-transfer torque RAM (STT-RAM) cells in the design of processor caches. Compared to the traditional SRAM caches, a multi-level cell (MLC) STT-RAM cache design is denser, fast, and consumes less energy. However, a number of critical issues remains to be solved before MLC STT-RAM technology can be deployed in processor caches. In this paper, we shall offer solutions to the issue of bit encoding as well as tackle the write endurance problem. The latter has been neglected in previous works on STT-RAM caches. We propose a set remapping scheme that can potentially prolong the lifetime of a MLC STT-RAM cache by 80× on average. Furthermore, a method for recovering the performance that may be lost in some applications due to set remapping is introduced.
Enhancing the Therapeutic Efficacy of Tamoxifen Citrate Loaded Span-Based Nano-Vesicles on Human Breast Adenocarcinoma Cells

Serious adverse effects and low selectivity to cancer cells are the main obstacles of long term therapy with Tamoxifen (Tmx). This study aimed to develop Tmx-loaded span-based nano-vesicles for delivery to malignant tissues with maximum efficacy. The effect of three variables on vesicle size (Y1), zeta potential (Y2), entrapment efficiency (Y3) and the cumulative percent release after 24 h (Y4) were optimized using Box-Behnken design. The optimized formula was prepared and tested for its stability in different storage conditions. The observed values for the optimized formula were 310.2 nm, − 42.09 mV, 75.45 and 71.70% for Y1, Y2, Y3, and Y4, respectively. The examination using electron microscopy confirmed the formation of rounded vesicles with distinctive bilayer structure. Moreover, the cytotoxic activity of the optimized formula on both breast cancer cells (MCF-7) and normal cells (BHK) showed enhanced selectivity (9.4 folds) on cancerous cells with IC50 values 4.7 ± 1.5 and 44.3 ± 1.3 μg/ml on cancer and normal cells, respectively. While, free Tmx exhibited lower selectivity (2.5 folds) than optimized nano-vesicles on cancer cells with IC50 values of 9.0 ± 1.1 μg/ml and 22.5 ± 5.3 μg/ml on MCF-7 and BHK cells, respectively. The promising prepared vesicular system, with greater efficacy and selectivity, provides a marvelous tool to overcome breast cancer treatment challenges.
[Malaria epidemiological analysis in Tengchong City from 2010 to 2015].

OBJECTIVE To analyze the malaria epidemiological characteristics in Tengchong City from 2010 to 2015, so as to provide the evidence for adjusting and formulating measures in the elimination stage. METHODS The malaria data were collected and analyzed by using Microsoft Excel 2010 in Tengchong City from 2010 to 2015. RESULTS There were 1 408 malaria cases reported in Tengchong City from 2010 to 2015, including 1 091 cases of Plasmodium vivax infection, 256 cases of P. falciparum infection, 5 cases of P. malariae infection, 1 case of Plasmodium ovale infection, 1 case of mixed infections, and 54 unclassified cases. Totally 1 390 imported cases were recorded and 98.06% of them (1 363/1 390) were imported from Myanmar. Most of the patients (n = 908) were aged from 21 to 40 years, and the male to female ratio was 11.03∶1. The highest-risk populations were farmers and migrant workers. The most cases were observed in April and June, and at that time, most of the floating workers returned. CONCLUSIONS Imported malaria is severe in Tengchong City, and there is a great challenge to malaria elimination.
Performance evaluation of poly-urethane foam packed-bed chemical scrubber for the oxidative absorption of NH3 and H2S gases

ABSTRACT The feasibility of open-pore polyurethane (PU) foam as packing material for wet chemical scrubber was tested for NH3 and H2S removals. The foam is inexpensive, light-weight, highly porous (low pressure drop) and provides large surface area per unit volume, which are desirable properties for enhanced gas/liquid mass transfer. Conventional HCl/HOCl (for NH3) and NaOH/NaOCl (for H2S) scrubbing solutions were used to absorb and oxidize the gases. Assessment of the wet chemical scrubbers reveals that pH and ORP levels are important to maintain the gas removal efficiencies >95%. A higher re-circulation rate of scrubbing solutions also proved to enhance the performance of the NH3 and H2S columns. Accumulation of salts was confirmed by the gradual increase in total dissolved solids and conductivity values of scrubbing solutions. The critical elimination capacities at >95% gas removals were found to be 5.24 g NH3-N/m3-h and 17.2 g H2S-S/m3-h at an empty bed gas residence time of 23.6 s. Negligible pressure drops (< 4 mm H2O) after continuous operation demonstrate the suitability of PU as a practical packing material in wet chemical scrubbers for NH3 and H2S removals from high-volume dilute emissions.
Association of multiple genetic variants with breast cancer susceptibility in the Han Chinese population

We selected 13 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with breast cancer risk in the Chinese Han population. Upon statistical analyses of clinical data from 551 patients and 577 controls, we found that six of the 13 SNPs were associated with breast cancer; namely, rs4973768(Odds ratio (OR) = 1.30, 95% confidence interval (CI) =1.01-1.67), rs981782(OR =1.30, 95% CI=1.01-1.66), rs1432679(OR =0.84, 95% CI=0.70-0.99), rs10759243(OR=1.30, 95%CI=1.09-1.55), rs10822013(OR =1.18, 95% CI=1.00-1.39) and rs704010(OR =1.63, 95% CI=1.04-2.56). When stratified based on breast cancer subtype, our analyses revealed that three SNPs (rs981782, rs10759243 and rs704010) correlated with ER+ breast cancer, while another three (rs4973768, rs1432679 and rs10822013) correlated with ER- breast cancer. We obtained similar results while investigating the correlation of SNPs with PR status or clinical stage. Our results suggest that associations identified between SNPs and breast cancer through genome-wide association studies (GWAS) may not always be generalizable across races.
Associations of Muscle Mass and Strength with All-Cause Mortality among US Older Adults

IntroductionRecent studies suggested that muscle mass and muscle strength may independently or synergistically affect aging-related health outcomes in older adults; however, prospective data on mortality in the general population are sparse. MethodsWe aimed to prospectively examine individual and joint associations of low muscle mass and low muscle strength with all-cause mortality in a nationally representative sample. This study included 4449 participants age 50 yr and older from the National Health and Nutrition Examination Survey 1999 to 2002 with public use 2011 linked mortality files. Weighted multivariable logistic regression models were adjusted for age, sex, race, body mass index (BMI), smoking, alcohol use, education, leisure time physical activity, sedentary time, and comorbid diseases. ResultsOverall, the prevalence of low muscle mass was 23.1% defined by appendicular lean mass (ALM) and 17.0% defined by ALM/BMI, and the prevalence of low muscle strength was 19.4%. In the joint analyses, all-cause mortality was significantly higher among individuals with low muscle strength, whether they had low muscle mass (odds ratio [OR], 2.03; 95% confidence interval [CI], 1.27–3.24 for ALM; OR, 2.53; 95% CI, 1.64–3.88 for ALM/BMI) or not (OR, 2.66; 95% CI, 1.53–4.62 for ALM; OR, 2.17; 95% CI, 1.29–3.64 for ALM/BMI). In addition, the significant associations between low muscle strength and all-cause mortality persisted across different levels of metabolic syndrome, sedentary time, and LTPA. ConclusionsLow muscle strength was independently associated with elevated risk of all-cause mortality, regardless of muscle mass, metabolic syndrome, sedentary time, or LTPA among US older adults, indicating the importance of muscle strength in predicting aging-related health outcomes in older adults.
Letter by Sonkar et al Regarding Article, "Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3)P-Directed Function of NADPH Oxidase".

We read with great interest the recent article by Liu et al1 on the role of phosphoinositide 3-kinase (PI3K) in platelet activation and thrombosis. Liu et al demonstrated that mice lacking platelet-specific VPS34, a PI3K isoform, exhibit diminished platelet activation and aggregation and are protected from accelerated thrombosis. This phenotype was associated with loss of translocation of the p40phox cytoplasmic subunit of NADPH (nicotinamide adenine dinucleotide phosphate) oxidase to the plasma membrane, suggesting that VPS34 may regulate platelet reactive oxygen species (ROS) generation and subsequent platelet activation by mediating assembly of a functional NADPH oxidase. The authors did not directly measure …
A 50 MHz BW 76.1 dB DR Two-Stage Continuous-Time Delta–Sigma Modulator With VCO Quantizer Nonlinearity Cancellation

A two-stage continuous-time <inline-formula> <tex-math notation="LaTeX">$\Delta \Sigma $ </tex-math></inline-formula> modulator with voltage-controlled oscillator based quantizer (VCOQ) is presented. The presented modulator suppresses the VCOQ voltage-to-frequency nonlinearity through dual path cancellation to achieve high linearity. As an added advantage, this architecture exhibits strong immunity to the first stage quantization error leakage to the output due to gain mismatches between the two stages. Fabricated in a 65 nm CMOS technology, the prototype modulator operates at 1.5 GS/s and achieves 76.1 dB SNR, 73.5 dB SNDR, 88 dB SFDR, and 76.1 dB dynamic range (DR) in 50 MHz bandwidth. This prototype demonstrates robust performance with less than 1.5 dB variation in SNDR for ±10% gain mismatch between the two stages. Also, the SNDR variation remains within 1 dB for a temperature variation of 0°C–80°C. The modulator consumes 51.8 mW of power leading to a Walden FoM of 134 fJ/conv-step.
Zinc‐induced Structural Effects Enhance Oxygen Consumption and Superoxide Generation in Synthetic Pheomelanins on UVA/Visible Light Irradiation †

The abnormal susceptibility of red‐haired individuals to UV‐induced inflammation and skin cancers is commonly attributed to the marked photoreactivity of pheomelanin pigments, which would be responsible for the sustained generation of reactive oxygen species in the skin following sun exposure. The structural factors determining pheomelanin photolability remain mostly unknown. Here, we describe the effects of zinc ions, typically found at high levels in red hair, in enhancing both oxygen consumption and superoxide production in model pheomelanin pigments following irradiation with UVA and visible light. Electron paramagnetic resonance (EPR) oximetry and EPR‐spin trapping experiments with synthetic pheomelanins, prepared by oxidation of dopa and cysteine or isomeric cysteinyldopas under different conditions, indicate a higher photoreactivity of the pigments prepared in the presence of zinc ions compared with those obtained in the absence of the metal. Quantitative analysis of thiazole‐containing structural markers of the synthetic pheomelanins provides evidence that the effect of zinc ions is due to modification of the formation pathway and structural features of the pigments. Overall, these results point to a hitherto unrecognized critical role of zinc ions in pheomelanogenesis, which may affect the intrinsic photoreactivity of the pigment.
From ego network to social network models

The development of routing protocols for human pervasive networks can not disregard contextual information. Social network models can help researches giving information about human behaviors, e.g. estimating contact opportunities between nodes. In a previous work we defined a model for ego networks while in this work we present a method to integrate ego networks and obtain synthetic social networks ready-to-use for the development of routing protocols.