Miracle-dz/UniFAR-FTUs huggingface dataset:
Do We Know Enough about Requirements Prioritization in Agile Projects: Insights from a Case Study

Requirements prioritization is an essential mechanism of agile software development approaches. It maximizes the value delivered to the clients and accommodates changing requirements. This paper presents results of an exploratory cross-case study on agile prioritization and business value delivery processes in eight software organizations. We found that some explicit and fundamental assumptions of agile requirement prioritization approaches, as described in the agile literature on best practices, do not hold in all agile project contexts in our study. These are (i) the driving role of the client in the value creation process, (ii) the prevailing position of business value as a main prioritization criterion, (iii) the role of the prioritization process for project goal achievement. This implies that these assumptions have to be reframed and that the approaches to requirements prioritization for value creation need to be extended.
Ring Paxos: High-Throughput Atomic Broadcast

Atomic broadcast is an important communication primitive often used to implement state-machine replication. Despite the large number of atomic broadcast algorithms proposed in the literature, few papers have discussed how to turn these algorithms into efficient executable protocols. This paper focuses on a class of atomic broadcast algorithms based on Paxos, with its corresponding desirable properties: safety under asynchrony assumptions, liveness under weak synchrony assumptions, and resiliency-optimality. The paper presents two protocols, M-Ring Paxos and U-Ring Paxos, derived from Paxos. The protocols inherit the properties of Paxos and can be implemented very efficiently. We report a detailed performance analysis of M-Ring Paxos and U-Ring Paxos and compare them to other atomic broadcast protocols.
Effect of Rapid Ascent to High Altitude on Autonomic Cardiovascular Modulation

Background:Effect of acute hypobaric hypoxia on autonomic nervous activities remains unclear. We evaluated the effect of rapid ascent to high altitude on autonomic cardiovascular modulation and compared the differences between the subjects with and without acute mountain sickness (AMS). Method:Twenty-seven unacclimatized healthy subjects were included for this study. The sleep and study altitude (3180 m) was reached by car from low level (555 m) within 3 hours. The stationary spectral heart rate variability was measured 3 days before ascent (T0), 2 nights at high altitude (T1 and T2), and 2 days after descent (T3). AMS occurrence was evaluated by the Lake Louise score system. Results:At high altitude, RR intervals (RRI), standard deviation of RRI (SDRR), total power (TP), low-frequency power (LF), high-frequency power (HF), and normalized HF decreased significantly but normalized LF and LF/HF ratio increased significantly in subjects irrespective of AMS. AMS developed in 13 of 27 (48.1%) subjects. Compared with the data at T1, SDRR, TP, LF, and HF increased at T2 in AMS group but decreased in non-AMS group, and the differences in these variables (data at T2 minus data at T1) between the 2 groups showed statistical significance. Conclusions:After rapid ascent to high altitude, autonomic nervous activities were suppressed and sympathetic activity was relatively predominant. At high altitude, the discordant changes in SDRR, TP, LF, and HF may reflect varying capacity of acute hypobaric hypoxic adaptation between the subjects with and without AMS.
An Evidence-Based Algorithm for Intraoperative Monitoring During Cochlear Implantation

Objective To generate an evidence-based algorithm for the use of intraoperative testing during cochlear implantation (CI). Study Design Retrospective review. Setting Tertiary referral center. Patients A total of 277 children (aged 6 mo to 17 yr) and adults 18 years and older with normal cochlear anatomy who underwent primary and revision cochlear implantation at a single center between 2005 and 2010 were included. Intervention Intraoperative electrophysiologic monitoring and intraoperative Stenver’s view plain film radiography. Main Outcome Measure Intraoperative testing included the following: 1) individual electrode impedance measurements; 2) neural response telemetry (tNRT) levels for electrodes E20, E15, E10, and E5; and 3) plain film radiograph assessment of electrode position. Results No patient demonstrated abnormalities on all 3 modalities. Open or short electrodes on impedance testing were found in 6% of patients; half of these normalized when remeasured. Absent tNRT responses on 1 or more electrodes occurred in 14% of patients, although complete lack of response was rare (1.4%) and did not correlate with a dysfunctional device. Spread of excitation was performed in 1 patient and was consistent with a tip rollover. Intraoperative radiography identified tip-rollover and extracochlear electrode placement in all cases (n = 5, 1.8%) and prompted the use of the backup device. Conclusion Immediate intraoperative determination of device functionality and optimal electrode placement is advantageous. Of the modalities tested, including electrode impedance, tNRT, and plain radiograph, only the radiographic results impacted intraoperative surgical decision making and led to the use of the backup device.
A Fuzzy Approach to Image Texture Representation Applied to Visual Coarseness Description

Although "texture" is one of the most used features in image analysis, it is an ambiguous concept which, in many cases, is not easy to characterize. In this paper we face the problem of imprecision in texture description by proposing a methodology to represent texture concepts by means of fuzzy sets. Specifically, we model the concept of "coarseness", the most extended in texture analysis, relating representative measures of this kind of texture (usually some statistic) with its presence degree. To obtain these "presence degrees" related to human perception, we propose a methodology to collect assessments from polls filled by human subjects, performing an aggregation of these assessments by means of OWA operators. Using as reference set a combination of some statistics, the membership function corresponding to the fuzzy set "coarseness" will be modelled as the function which provides the best fit of the collected data. The proposed methodology could be extended to other types of texture concepts like orientation, roughness or regularity. The main novelty of this approach is the introduction of semantics in the texture analysis problem, by using linguistic labels represented by fuzzy sets in order to describe texture features.
Importance of Detecting Multidrug Resistance Proteins in Acute Leukemia Prognosis and Therapy

Multidrug resistance (MDR) is a multifactorial phenomenon and the role of these proteins in generating the MDR phenotype is controversial. With this in mind, this review compiled the current data on the role of ABCB1, ABCC1, and LRP proteins in the prognosis of hematologic neoplasms and their influence on the choice of therapy. Literature showed that the detection of these proteins, mainly ABCB1, is important in the AL prognosis. However, there is controversy regarding the methodology used for their detection. In summary, the expression and activity profiles of ABCB1, ABCC1, and LRP, proteins capable of promoting the efflux of a variety of chemotherapeutic agents from the cell cytoplasm represent one of the greatest causes of failure in AL treatment. J. Clin. Lab. Anal. 27:62–71, 2013. © 2012 Wiley Periodicals, Inc.
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*

Inhibitors of oncogenic B-RAFV600E and MKK1/2 have yielded remarkable responses in B-RAFV600E-positive melanoma patients. However, the efficacy of these inhibitors is limited by the inevitable onset of resistance. Despite the fact that these inhibitors target the same pathway, combination treatment with B-RAFV600E and MKK1/2 inhibitors has been shown to improve both response rates and progression-free survival in B-RAFV600E melanoma patients. To provide insight into the molecular nature of the combinatorial response, we used quantitative mass spectrometry to characterize the inhibitor-dependent phosphoproteome of human melanoma cells treated with the B-RAFV600E inhibitor PLX4032 (vemurafenib) or the MKK1/2 inhibitor AZD6244 (selumetinib). In three replicate experiments, we quantified changes at a total of 23,986 phosphosites on 4784 proteins. This included 1317 phosphosites that reproducibly decreased in response to at least one inhibitor. Phosphosites that responded to both inhibitors grouped into networks that included the nuclear pore complex, growth factor signaling, and transcriptional regulators. Although the majority of phosphosites were responsive to both inhibitors, we identified 16 sites that decreased only in response to PLX4032, suggesting rare instances where oncogenic B-RAF signaling occurs in an MKK1/2-independent manner. Only two phosphosites were identified that appeared to be uniquely responsive to AZD6244. When cells were treated with the combination of AZD6244 and PLX4032 at subsaturating concentrations (30 nm), responses at nearly all phosphosites were additive. We conclude that AZD6244 does not substantially widen the range of phosphosites inhibited by PLX4032 and that the benefit of the drug combination is best explained by their additive effects on suppressing ERK1/2 signaling. Comparison of our results to another recent ERK1/2 phosphoproteomics study revealed a surprising degree of variability in the sensitivity of phosphosites to MKK1/2 inhibitors in human cell lines, revealing unexpected cell specificity in the molecular responses to pathway activation.
Molecular Evolution of Fern Squalene Cyclases

Triterpenes, a diverse group of natural products comprising six isoprene units, are distributed across various organisms from bacteria to higher plants. Ferns are sporophytes that produce triterpenes and are lower on the evolutionary scale than higher plants. Among ferns that produce triterpenes analogous to bacterial hopanoids, Polypodiodes niponica produces migrated dammaranes and oleananes, which are also widely found in higher plants. Because the study of terpene‐producing ferns could help us to understand the molecular basis of triterpene biosynthesis, cDNA cloning of squalene cyclases (SCs) from P. niponica was carried out. Two SCs (PNT and PNG) were obtained. The heterologously expressed PNT produces tirucalla‐7,21‐diene (67 % major), and PNG produces germanicene (69 %). Phylogenetic analysis revealed that PNT and PNG, which produce higher‐plant‐type migrated dammaranes and oleananes, are closely related to bacterial‐type SCs. Furthermore, analysis of the minor products indicated that fern SCs gained the ability to directly form dammarenyl cations, which are key intermediates in oleanane formation during molecular evolution.
Gradient domain high dynamic range compression

We present a new method for rendering high dynamic range images on conventional displays. Our method is conceptually simple, computationally efficient, robust, and easy to use. We manipulate the gradient field of the luminance image by attenuating the magnitudes of large gradients. A new, low dynamic range image is then obtained by solving a Poisson equation on the modified gradient field. Our results demonstrate that the method is capable of drastic dynamic range compression, while preserving fine details and avoiding common artifacts, such as halos, gradient reversals, or loss of local contrast. The method is also able to significantly enhance ordinary images by bringing out detail in dark regions.
Noise Texture Deviation: A Measure for Quantifying Artifacts in Computed Tomography Images With Iterative Reconstructions

Objectives The aims of this study were to introduce the measure noise texture deviation as quantitative parameter for evaluating iterative reconstruction (IR)–specific artifacts in computed tomography (CT) images and to test whether IR-specific artifacts, quantified through this measure, are reduced in advanced modeled IR (ADMIRE) as compared with sinogram-affirmed IR (SAFIRE) images of the liver ex vivo and in patients with hypodense liver lesions. Materials and Methods In the ex vivo study part, an abdominal phantom was used. In the institutional review board–approved in vivo study part, 40 consecutive patients (mean age, 63 years) with hypodense liver lesions undergoing abdominal CT in the portal-venous phase were included. Images were reconstructed with filtered back projection, with the second-generation IR algorithm SAFIRE and with the third-generation IR algorithm ADMIRE. Noise power spectra and noise texture deviation were calculated in the phantom; image noise was measured in the phantom and in patients. Two blinded readers evaluated all image data regarding IR-specific artifacts (plastic-like, blotchy appearance); patient data were evaluated regarding conspicuity and confidence for detecting hypodense liver lesions. Results Image noise was significantly reduced at increasing IR levels (P < 0.001) with both algorithms, with no significant differences between corresponding strength levels of SAFIRE and ADMIRE (all, P > 0.05). Noise power spectra were similar at corresponding strength levels of SAFIRE and ADMIRE (all, P > 0.05). Noise texture deviation in ADMIRE was reduced compared with corresponding strength levels of SAFIRE (all, P < 0.001) and strongly correlated with subjective IR-specific artifacts (r = 0.88, P < 0.001). Iterative reconstruction–specific artifacts were significantly reduced in ADMIRE compared with that in SAFIRE images at strength levels 3 or greater, both ex vivo and in vivo (all, P < 0.001). There were no significant differences in the readers' ratings of lesion conspicuity and lesion confidence in detecting hypodense liver lesions between SAFIRE and ADMIRE (P > 0.05). Only lesion conspicuity was superior with SAFIRE and ADMIRE compared with filtered back projection (all, P < 0.001). Conclusions Noise texture deviation is a quantitative measure reflecting IR-specific artifacts and is reduced in CT images with ADMIRE compared with SAFIRE.
Identification and Severity Determination of Wheat Stripe Rust and Wheat Leaf Rust Based on Hyperspectral Data Acquired Using a Black-Paper-Based Measuring Method

It is important to implement detection and assessment of plant diseases based on remotely sensed data for disease monitoring and control. Hyperspectral data of healthy leaves, leaves in incubation period and leaves in diseased period of wheat stripe rust and wheat leaf rust were collected under in-field conditions using a black-paper-based measuring method developed in this study. After data preprocessing, the models to identify the diseases were built using distinguished partial least squares (DPLS) and support vector machine (SVM), and the disease severity inversion models of stripe rust and the disease severity inversion models of leaf rust were built using quantitative partial least squares (QPLS) and support vector regression (SVR). All the models were validated by using leave-one-out cross validation and external validation. The diseases could be discriminated using both distinguished partial least squares and support vector machine with the accuracies of more than 99%. For each wheat rust, disease severity levels were accurately retrieved using both the optimal QPLS models and the optimal SVR models with the coefficients of determination (R2) of more than 0.90 and the root mean square errors (RMSE) of less than 0.15. The results demonstrated that identification and severity evaluation of stripe rust and leaf rust at the leaf level could be implemented based on the hyperspectral data acquired using the developed method. A scientific basis was provided for implementing disease monitoring by using aerial and space remote sensing technologies.
Activated Protein C Protects Myocardium Via Activation of Anti-apoptotic Pathways of Survival in Ischemia-reperfused Rat Heart

Activated protein C (APC) is known to be beneficial on ischemia reperfusion injury in myocardium. However, the protection mechanism of APC is not fully understood. The purpose of this study was to investigate the effects and possible mechanisms of APC on myocardial ischemic damage. Artificially ventilated anaesthetized Sprague-Dawley rats were subjected to a 30 min of left anterior descending coronary artery occlusion followed by 2 hr of reperfusion. Rats were randomly divided into four groups; Sham, I/R, APC preconditioning and postconditioning group. Myocardial infarct size, apoptosis index, the phosphorylation of ERK1/2, Bcl-2, Bax and cytochrome c genes and proteins were assessed. In APC-administrated rat hearts, regardless of the timing of administration, infarct size was consistently reduced compared to ischemia/reperfusion (I/R) rats. APC improved the expression of ERK1/2 and anti-apoptotic protein Bcl-2 which were significantly reduced in the I/R rats. APC reduced the expression of pro-apoptotic genes, Bax and cytochrome c. These findings suggest that APC produces cardioprotective effect by preserving the expression of proteins and genes involved in anti-apoptotic pathways, regardless of the timing of administration.
Characterizing End-to-end Internet Performance

The Internet has undergone dramatic growth in connectivity, use, and quality of service over the past several years. As this growth continues and the Internet is used for increasingly diverse and demanding purposes, it is vital to understand how the network and applications behave across a wide range of scenarios. In this thesis, we have attempted to characterize end-to-end Internet performance at both the network layer and the application layer. At the network layer, we concentrate on the fundamental question of the constancy of Internet path properties. Today's networking practices often assume various forms of constancy of the underlying network properties. In order to provide general guidance about when and over what time scales these assumptions are valid, we have gathered a large measurement dataset using the NIMI infrastructure and then examined various notions of constancy in the context of four core Internet path properties: routes, loss, delay, and throughput. At the application layer, we provide a detailed discussion and analysis of a large-scale Internet application, content distribution networks (CDNs). CDNs have recently emerged as a popular mechanism for delivering content on behalf of the origin Web sites. To test whether CDNs improve Web performance in reality, we have conducted the first large-scale measurement based study on CDNs, focusing on how they are used on the Web and how well they perform in terms of client download time. Our study not only is timely, but also provides a baseline on an effective way to evaluate large-scale Internet systems and applications. Throughout our study, we have paid considerable effort to deal with various measurement and analysis difficulties introduced by the tremendous diversity of the Internet. We hope that such effort has allowed us to draw a realistic picture of today's end-to-end Internet performance and to provide useful insights on how to effectively design and provision the future network. Meanwhile, we have attempted to gather the right set of concepts and tools that can be applied to understand various aspects of end-to-end Internet performance even when the network traffic condition changes. We hope these fundamental concepts and tools might have long-lived value.
Alterations of intestinal immune function and regulatory effects of L-arginine in experimental severe acute pancreatitis rats.

AIM To discuss the changes of intestinal mucosal immune function in rats with experimental severe acute pancreatitis (SAP) and the regulatory effect of L-arginine. METHODS Male adult Wistar rats were randomly divided into pancreatitis group, sham-operation group, and L-arginine treatment group. Animals were killed at 24, 48, and 72 h after SAP models were developed and specimens were harvested. Endotoxin concentration in portal vein was determined by limulus endotoxin analysis kit. CD3+, CD4+, CD8+ T lymphocytes in intestinal mucosal lamina propria were examined by immunohistochemistry. Secretory immunoglobulin A (SIgA) in cecum feces was examined by radioimmunoassay. RESULTS Compared to the control group, plasma endotoxin concentration in the portal vein increased, percentage of CD3+ and CD4+ T lymphocyte subsets in the end of intestinal mucosal lamina propria reduced significantly, CD4+/CD8+ ratio decreased, and SIgA concentrations in cecum feces reduced at 24, 48, and 72 h after SAP developed. Compared to SAP group, the L-arginine treatment group had a lower level of plasma endotoxin concentration in the portal vein, a higher CD3+ and CD4+ T lymphocyte percentage in the end of intestinal mucosal lamina propria, an increased ratio of CD4+/CD8+ and a higher SIgA concentration in cecum feces. CONCLUSION Intestinal immune suppression occurs in the early stage of SAP rats, which may be the main reason for bacterial and endotoxin translocation. L-arginine can improve the intestinal immunity and reduce bacterial and endotoxin translocation in SAP rats.
Differential Diagnosis in Idiopathic Granulomatous Mastitis and Tuberculous Mastitis

Purpose Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory disease of unknown etiology. The diagnosis of IGM requires that other granulomatous lesions in the breast be excluded. Tuberculous mastitis (TM) is also an uncommon disease that is often difficult to differentiate from IGM. The purpose of this study is to develop a new algorithm for the differential diagnosis and treatment of IGM and TM. Methods Medical records of 68 patients (58 with IGM and 10 with TM) between July 1999 and February 2009 were retrospectively reviewed. Results The mean age of the patients was 33.5 (IGM) and 40 (TM) years (p=0.018). The median follow-up was 84 months. Of the total 10 patients with TM, 5 patients had a history of pulmonary tuberculosis. The most common symptoms of the diseases were breast lump and pain. However, axillary lymphadenopathy was more seen in TM (50%) compared to IGM (20.6%) (p=0.048). TM showed more cancer-mimicking findings on radiologic study (p=0.028). In IGM, 48 patients (82.7%) underwent surgical wide excision and 21 patients (36.2%) were managed with corticosteroid therapy and antibiotics. All of the TM patients received anti-tuberculosis medications and 9 patients (90%) underwent wide excision. The mean treatment duration was 2.8 months in IGM and 8.4 months in TM. Recurrence developed in 5 patients (8.6%) in IGM and 1 patient (10%) in TM. Conclusion This study shows different characteristics between IGM and TM. The IGM patients were younger and had more mastalgia symptoms than the TM patients. Axillary lymphadenopathy was seen more often in TM patients. Half of the TM patients had pulmonary tuberculosis or tuberculosis lymphadenitis. Surgical wide excision might be both therapeutic and useful for providing an exact diagnosis.
Coping Strategies Used by School Staff After a Crisis: A Research Note

There is much literature on crisis support in schools but little on how school staff are affected. This research had two aims: to begin to explore the coping strategies used by school staff after a crisis event, and to investigate measures that might prove valuable for future research. Seven cases are presented using three measures: the WHO (Five) Wellbeing Index, the Impact of Event Scale–Revised, and the Ways of Coping–Revised. Results from this initial study show great variation in the range of responses reported by teachers.