Miracle-dz/UniFAR-FTUs huggingface dataset:
The incidence of alcohol-associated osteonecrosis of the knee is lower than the incidence of steroid-associated osteonecrosis of the knee: an MRI study.

OBJECTIVE The purpose of the study was to clarify the incidence of alcohol-associated osteonecrosis of the knee using MRI. METHODS A total of 131 patients (56 women and 75 men) with osteonecrosis of the femoral head were enrolled; 60 patients had a history of alcohol abuse and 71 had previously received steroids. All patients underwent MRI of the knee. The incidence of alcohol-associated osteonecrosis of the knee was compared with that of steroid-associated osteonecrosis of the knee. Predictive factors of alcohol- and steroid-associated osteonecrosis of the knee were also evaluated. RESULTS The incidence of alcohol-associated osteonecrosis of the knee was lower than that of steroid-associated osteonecrosis of the knee (18.3 vs 54.9%; P < 0.001, Fisher's exact probability test). No significant difference in weekly alcohol consumption was observed between patients with osteonecrosis of the knee and those without osteonecrosis of the knee. No significant difference in daily maximum steroid doses was observed between patients with osteonecrosis of the knee and those without osteonecrosis of the knee. CONCLUSION The present study revealed that the incidence of alcohol-associated osteonecrosis of the knee is lower than that of steroid-associated osteonecrosis of the knee.
Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation

Selenium deficiency is known to be associated with male infertility, and the selenoprotein PHGPx has been shown to increase in rat testis after puberty and to depend on gonadotropin stimulation in hypophysectomized rats [Roveri et al. (1992) J. Biol. Chem. 267, 6142–6146]. Exposure of decapsulated whole testis, however, failed to reveal any transcriptional activation or inhibition of the PHGPx gene by testosterone, human chorionic gonadotropin, or forskolin. Nevertheless, it was verified that the specific activity of PHGPx in testis, but not of cGPx, correlated with sexual maturation. Leydig cell destruction in vivo by ethane dimethane sulfonate (EDS) resulted in a delayed decrease in PHGPx activity and mRNA that could be completely prevented by testosterone substitution. cGPx transiently increased upon EDS treatment, probably as a result of reactive macrophage augmentation. In situ mRNA hybridization studies demonstrated an uncharacteristic low level of cGPx transcription in testis, whereas PHGPx mRNA was abundantly and preferentially expressed in round spermatids. The data show that the age or gonadotropin‐dependent expression of PHGPx in testis does not result from direct transcriptional gene activation by testosterone, but is due to differentiation stage‐specific expression in late spermatids, which are under the control of Leydig cell‐derived testosterone. The striking burst of PHGPx expression at the transition of round to elongated spermatids suggests an involvement of this selenoprotein in sperm maturation. —Maiorino, M. , Wissing, J. B. , Brigelius‐ Flohe´, R. , Calabrese, F. , Roveri, A. , Steinert, P., Ursini, F. , Flohe´, L. Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation. FASEB J. 12, 1359–1370 (1998)
Face processing in schizophrenia: defining the deficit

Background. Abnormalities of face affect naming and face recognition occur in schizophrenia but it is not clear whether the deficits reflect wider underlying impairments of perception, memory, language or executive function. Method. Twenty-six patients with schizophrenia were compared with 23 healthy volunteers on neuropsychological tests and tests of face and affect processing. Face and non-face tests were compared at four levels of processing: visuo-spatial perception, recognition memory, language and naming, and executive function. We examined relationships with drug dose, duration of illness and pre-morbid and current IQ. Results. Patients and controls did not differ in estimated pre-morbid IQ but current IQ was 12 points lower in patients. At each level of processing there were correlated deficits of face and non-face processing in the patients that were mostly independent of IQ decline. Impaired face and non-face visuo-spatial function and recognition performance were generally correlated with drug dose. Impairments in naming face emotions were correlated with other non-face naming tasks independently of drug dose. Patients performed less well than controls in classifying faces by emotion while ignoring identity and this was associated with poorer performance in Wisconsin Card Sorting. Conclusions. The pattern of results suggests that deficits in face processing reflect three wider neuropsychological impairments: a drug-related impairment of visual imagery, and disease-related impairments of semantic retrieval and executive function.
Seroprevalence of Bartonella henselae, Toxoplasma gondii, FIV and FeLV Infections in Domestic Cats in Japan

Seroprevalence of Bartonella henselae, Toxoplasma gondii, feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) infections was investigated in 1,447 domestic cats derived from the north (Hokkaido) to the south (Okinawa) prefectures in Japan. Of the cats investigated, 8.8% (128/1,447) were seropositive to B. henselae, 5.4% (78/1,447) to T. gondii, 9.8% (107/1,088) to FIV, and 2.9% (32/1,088) to FeLV, respectively. For B. henselae infection, the positive rate varied from 11.5% in cats of 1 to <2 years old to 7.2% in those over 3 years old. Outdoor cats showed higher positive rate (14.5%) than that (7.0%) in indoor ones. The rate (13.5%) in flea‐infested cats was significantly higher than that (7.4%) in flea‐negative cats. The positive rates in southern and urban sites were more likely to be higher than those in northern and suburban sites, suggesting that warm and humid environments, density of cat population, and raising status, including hygienic condition and flea infestation in cats may correlate to higher seroprevalence of B. henselae infection. For T. gondii, FIV and FeLV infections, the seroprevalence also tended to be higher in outdoor, flea‐infested cats and advanced age groups. For FIV infection, the positive rates in male (14.3%) and outdoor cats (15.0%) were significantly higher than those in female (5.0%) and indoor cats (4.6%). On the other hand, no significant difference in seropositivities was observed in FeLV and T. gondii infections concerning to both genders and raising status.
Propuesta de un programa de prevención de trastornos de la conducta alimentaria para entrenadores

I this work we are going to present a proposal to develop a program to prevent eating disorders (ED) in sportsmen/women, aimed at coaches. Initially, we are going to cosider ED in sport, focusing on sports cosidered high risk and likely to develop ED. After that, we show the situation of the prevention of these disorders in sports, analysing the investigations that reveal he importance of including coaches in preventive activities. Finally we are going to suggest a program of workshops aimed at coaches in order to involve them in the prevention of ED.
Perceived Overqualification: A Multi-Source Investigation of Psychological Predisposition and Contextual Triggers

ABSTRACT. Although employee (subjective) perceived overqualification (POQ) has recently been explored as a meaningful organizational construct, further work is needed to fully understand it. We extend the theoretical psychological underpinnings of employee POQ and examine both its determinants and outcomes based on established and newly proposed theoretical developments. Four-hundred and fifteen employees completed an online questionnaire and 208 of their supervisors completed corresponding surveys about the employees’ withdrawal behaviors and job-related attitudes, in order to explore potential predictors and outcomes of subjectively experienced POQ. Among the predictors, work conditions (uniform requirements and repetitive tasks) were most strongly associated with POQ. In terms of individual differences, narcissism predicted higher POQ while general mental ability only did when holding other variables constant. In addition, among the outcomes, higher POQ was related to lower job satisfaction and organizational commitment, but was not related to withdrawal behaviors such as truancy, absenteeism, and turnover intentions.
Language ability, executive functioning and behaviour in school-age children

Background Many children with language impairment present with deficits in other areas, including executive functioning (EF), attention and behaviour. Similarly, many children receiving services for attention or behaviour problems have deficits in language ability. Aims To evaluate the relations among EF, language ability and behaviour problems in a sample of school-age children with a wide range of language and behaviour profiles. The following research questions were addressed: Does performance on EF tasks predict language ability? Do language ability and EF predict problems with attention, internalizing and/or externalizing? Methods & Procedures EF was defined as referring to the separable, yet related, processes of shifting, updating working memory and inhibition as specified in the latent variable model of EF. Children aged 8–11 years recruited from an urban school district completed standardized language and cognitive assessments and a computerized task assessing EF. Their parents completed standardized questionnaires assessing the children's EF and problem behaviours. Regression analyses were conducted. Outcomes & Results Regression analyses revealed that EF did not contribute to language ability beyond the variance accounted for by nonverbal reasoning. Language ability contributed to attention problems when entered as a single predictor, but was no longer significant when the EF measures were added to the model. Language ability did not significantly contribute to internalizing or externalizing behaviour problems. Parent-reported inhibition was a robust predictor of attention, internalizing and externalizing behaviour problems. Conclusions & Implications In this sample of school-age children, language ability was related to attention problems, but not to internalizing or externalizing. Children with behaviour problems may have particular difficulty with inhibition.
A Computational Framework for Quantitative Evaluation of Movement during Rehabilitation

This paper presents a novel generalized computational framework for quantitative kinematic evaluation of movement in a rehabilitation clinic setting. The framework integrates clinical knowledge and computational data‐driven analysis together in a systematic manner. The framework provides three key benefits to rehabilitation: (a) the resulting continuous normalized measure allows the clinician to monitor movement quality on a fine scale and easily compare impairments across participants, (b) the framework reveals the effect of individual movement components on the composite movement performance helping the clinician decide the training foci, and (c) the evaluation runs in real‐time, which allows the clinician to constantly track a patient’s progress and make appropriate adaptations to the therapy protocol. The creation of such an evaluation is difficult because of the sparse amount of recorded clinical observations, the high dimensionality of movement and high variations in subject’s performance. We addres.
Effects of proteoglycan extraction on the tensile behavior of articular cartilage

We undertook an interdisciplinary biomechanical and biochemical study to explore the extent and manner in which the total pool of proteoglycans influences the kinetic and static behavior of bovine articular cartilage in tension. Two biomechanical tests were used: (a) the viscoelastic creep test and (b) a slow constant‐rate uniaxial tension test; and two enzymatic proteoglycan extraction procedures were used: (a) chondroitinase ABC treatment and (b) a sequential enzymatic treatment with chondroitinase ABC, trypsin, and Streptomyces hyaluronidase. We found that the viscoelastic creep response of all cartilage specimens may be divided into two distinct phases: an initial phase (< 15 s), characterized by a rapid increase in strain following load application, and a late phase (15 s < t < 25,000 s), characterized by a more gradual increase in strain. A major finding of this study is that the kinetics of the creep response is greatly influenced by the glycosaminoglycan content of the tissue. For untreated and control specimens, the initial response comprises about 50% of the total strain, while for chondroitinase ABC and sequentially extracted specimens, the initial response comprises up to 83% of the total strain. Furthermore, most untreated and control specimens did not reach equilibrium within the 25,000 s test period, while enzymatically digested specimens often reached equilibrium in less than 100 s. Thus, we conclude that through their physical restraints on collagen, the bulk of proteoglycan present in the tissue acts to retard fibrillar reorganization and alignment under tensile loading, thereby effectively preventing sudden extension of the collagen network. In contrast, the results of our slow constant‐rate uniaxial tension experiment show that essentially complete extraction of proteoglycan glycosaminoglycans does not affect the intrinsic tensile stiffness and strength of cartialge specimens or the collagen network in a significant manner. Hence, an important function of the bulk proteoglycans (i.e., the large aggregating type) in cartilage is to retard the rate of stretch and alignment when a tensile load is suddenly applied. This mechanism may be useful in protecting the cartilage collagen network during physiological situations, where sudden impact forces are imposed on a joint.
What Works for Whom?: A Critical Review of Treatments for Children and Adolescents

Introduction and Review of Outcome Methodology: The Importance of Outcome Measurement. Epidemiology. Anxiety Disorders. Depressive Disorders. Disturbance of Conduct. Attention-Deficit/Hyperactivity Disorder. Tourette's Disorder. Psychotic Disorders. Pervasive Developmental Disorders. Self-harming Disorders. Children with Physical Symptoms. Specific Developmental Disorders. Conclusions and Implications. Appendices: 1. Glossary of Psychopharmacological Treatments. 2. Search Terms.
Rgs5 Targeting Leads to Chronic Low Blood Pressure and a Lean Body Habitus

ABSTRACT RGS5 is a potent GTPase-activating protein for Giα and Gqα that is expressed strongly in pericytes and is present in vascular smooth muscle cells. To study the role of RGS5 in blood vessel physiology, we generated Rgs5-deficient mice. The Rgs5−/− mice developed normally, without obvious defects in cardiovascular development or function. Surprisingly, Rgs5−/− mice had persistently low blood pressure, lower in female mice than in male mice, without concomitant cardiac dysfunction, and a lean body habitus. The examination of the major blood vessels revealed that the aortas of Rgs5−/− mice were dilated compared to those of control mice, without altered wall thickness. Isolated aortic smooth muscle cells from the Rgs5−/− mice exhibited exaggerated levels of phosphorylation of vasodilator-stimulated phosphoprotein and extracellular signal-regulated kinase in response to stimulation with either sodium nitroprusside or sphingosine 1-phosphate. The results of this study, along with those of previous studies demonstrating that RGS5 stability is under the control of nitric oxide via the N-end rule pathway, suggest that RGS5 may balance vascular tone by attenuating vasodilatory signaling in vivo in opposition to RGS2, another RGS (regulator of G protein signaling) family member known to inhibit G protein-coupled receptor-mediated vasoconstrictor signaling. Blocking the function or the expression of RGS5 may provide an alternative approach to treat hypertension.
An exploration of school counselors' knowledge sharing practices using diffusion of innovation theory, social exchange theory, and theory of reasoned action

School counselors are expected to be advocates, collaborators, consultants, and leaders in their work with students, families, administrators, school staff, and community based stakeholders (ASCA, 2005; Shoffner & Briggs, 2001; Rowley, 2000). Underlying these expectations is the belief that school counselors are knowledgeable in the areas that allow them to fulfill these professional roles effectively. Knowledge seems to be a foundation of school counselors’ work. Despite the inclusion of knowledge in discussions of school counselor training (CACREP, 2009) and role expectations (Scarborough & Culbreth, 2008), school counselors’ knowledge, as an isolated construct has not been investigated thus far in the school counseling literature. Three main theories related to knowledge sharing were used as a starting point for discussing school counselors’ knowledge sharing practices: diffusion of innovation theory (Rogers, 1962), social exchange theory (Homans, 1958), and theory of reasoned action (Fishbein & Ajzen, 1975). These theories were not intended to be tested nor applied as a result of this particular study. Instead findings will be reported that seem to coincide with these three theories, as well as finding that seem to differ from these theories’ explanations of knowledge sharing. Seven individual interviews were conducted with practicing school counselors to collect data about school counselors’ knowledge sharing experiences. A focus group of six school counselors served a stability check. Consensual Qualitative Research (CQR)was utilized as this study’s methodology. Eight domains surfaced as a result of the interviews: 1) benefits and outcomes of knowledge sharing, 2) consequences of nonsharing of knowledge, 3) factors that influence knowledge sharing, 4) reasons for sharing knowledge, 5) knowledge sharing behaviors, 6) knowledge sharing content, 7) who knowledge is shared with, and 8) technology used for knowledge sharing purposes. The implications of these research findings can be applied to school counselors, but also extend beyond school counselors to include the larger counselor education community, as well as educational leaders.
Identity Conflict or Compatibility: A Comparison of Muslim Minorities in Five European Cities

Drawing on large-scale comparative surveys across nine sociopolitical contexts, we address the question when and why ethno-religious and city or national identities of European-born Muslims are in conflict. We argue that the sociopolitical context makes the difference between identity compatibility or conflict and that conflict arises from perceived discrimination and related negative feelings towards the national majority. Using multigroup structural equation modelling, we examine how Turkish and Moroccan Muslims in five European cities combine their civic membership of the city and country of residence—as common identities shared with the national majority—with distinct ethnic and religious identities. In all sociopolitical contexts, participants combined significant city and national identities with strong ethnic and religious identifications. Yet, identification patterns varied between contexts from conflict (negatively correlated minority and civic identities) over compartmentalization (zero correlations) to compatibility (positive correlations). Muslims who perceived more personal discrimination were more committed to their ethnic and religious identities while simultaneously dis-identifying from their country and city. Across cities, discrimination experiences and negative majority-group evaluations explained away identity conflict.
Strategic commitment and cooperation in experimental games of strategic complements and substitutes

We study the impact of strategic commitment on cooperation in indefinitely repeated games ofstrategic substitutes (Cournot) and complements (Bertrand) using laboratory experiments. Overall,strategic commitment has no effect on cooperation with strategic substitutes and a negative onewith strategic complements. In the absence of strong strategic commitment, we find morecooperation in the complements game than in the substitutes game. However, when subjects are morecommitted to initial plans, a higher level of cooperation is achieved with strategic substitutes.These results cannot be explained by standard risk-dominance or renegotiation considerations, butare consistent with a notion of fear of miscoordination based on minmax regret.
Ouderlijke mediasocialisatie: hulpbron of handicap? Een studie naar de langetermijneffecten van mediasocialisatie op het onderwijssucces van kinderen

In this article we analyzed the long term effects of parental media socialization on educational success. We employed information on 7838 individuals from 3083 families in the Netherlands to estimate hierarchical models that distinguish between family-specific (socialization) effects and individual effects. Our study reveals that parental media socialization plays a meaningful role in the intergenerational transmission of social inequality. Whereas parental time spent on television viewing actually harms a child’s educational career, parental reading intensity benefits school success. The content of the parental media consumption plays a relevant role in the reproduction process as well. A parental role model emphasizing highbrow reading enhances school success. Parents actually restrict their children’s educational success by showing a strong preference for popular TV. Beside the parental role model on media use we studied instructive media guidance performed by parents. Our results showed that parent-child interaction on reading positively affects children’s educational career.
Design of a 50nW, 0.5VDD sub-threshold OTA amplifier with indirect compensation technique and class AB output stage

We present analysis and design of a 0.5VDD two stage OTA amplifier with current-buffer compensation and class AB output stage in 90nm CMOS technology. All transistors in the amplifier operate in the sub-threshold region while achieving 86dB DC gain and unity gain frequency 40.5kHz with a load capacitor of 30pF. The total power dissipation is 50nW with bias current of 10nA.