Miracle-dz/UniFAR-FTUs huggingface dataset:
Evidence Supporting Zoonotic Transmission of Cryptosporidium spp. in Wisconsin

ABSTRACT Cryptosporidium hominis and Cryptosporidium parvum are the primary species of Cryptosporidium that infect humans. C. hominis has an anthroponotic transmission cycle, while C. parvum is zoonotic, infecting cattle and other ruminants, in addition to humans. Most cryptosporidiosis outbreaks in the United States have been caused by C. hominis, and this species is often reported as the primary cause of cryptosporidiosis in this country. However, outbreaks account for only 10% of the overall cryptosporidiosis cases, and there are few data on the species that cause sporadic cases. The present study identified the species/genotypes and subgenotypes of Cryptosporidium in 49 cases of sporadic cryptosporidiosis in Wisconsin during the period from 2003 to 2005. The species/genotype of isolates was determined by PCR restriction fragment length polymorphism analysis of the 18S rRNA and Cryptosporidium oocyst wall protein genes. The C. parvum and C. hominis isolates were subgenotyped by sequence analysis of the GP60 gene. Forty-four of 49 isolates were identified as C. parvum, and 1 was identified as C. hominis. Of the remaining isolates, one was identified as being of the cervine genotype, one was identified as being a cervine genotype variant, and two were identified as being of a novel human genotype, previously reported as W17. Nine different subgenotypes were identified within the C. parvum species, and two of these were responsible for 60% of the cases. In this study we found that most sporadic cases of cryptosporidiosis in Wisconsin are caused by zoonotic Cryptosporidium species, indicating that zoonotic transmission could be more frequently associated with sporadic cases in the United States.
The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome.

BACKGROUND Oxidative stress and hyperhomocysteinaemia are risk factors for cardiovascular diseases. The aim of this study was to assess the effects of rosiglitazone and metformin on cardiovascular disease risk factors such as insulin resistance, oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome (PCOS). METHODS Fifty lean patients (BMI <25 kg/m2) with PCOS and 35 healthy subjects were included this study. Serum homocysteine, sex steroids, fasting insulin, fasting glucose and lipid levels were measured. Total antioxidant status (TAS; combines concentrations of individual antioxidants) and malonyldialdehyde concentration (MDA) were determined. Insulin resistance was evaluated by using the homeostasis model insulin resistance index (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), Area under the curve insulin (AUCI) and the insulin sensitivity index (ISI). Patients were divided into two groups. One group was treated with metformin (n = 25) and the other received rosiglitazone (n = 25) for 12 weeks. All measurements were repeated at the end of 12 weeks. RESULTS Compared with healthy women, those with PCOS had significantly elevated serum MDA, homocysteine, HOMA-IR, AUCI and lipoprotein a levels, and significantly decreased serum TAS, QUICKI and ISI. Serum free testosterone levels showed a significant positive correlation with MDA, AUCI and HOMA-IR, and a negative correlation with TAS, ISI and QUICKI in PCOS patients. HOMA-IR and AUCI significantly decreased, while QUICKI and ISI significantly increased after treatment in both groups. Serum TAS level increased and serum MDA level decreased after the rosiglitazone treatment, but these parameters did not change after the metformin treatment. Serum homocysteine and lipid levels did not change in either group, while serum androgen levels and LH/FSH ratio significantly decreased after the treatment period in only the rosiglitazone-treated group. CONCLUSION Elevated insulin resistance, oxidative stress and plasma homocysteine levels and changes in serum lipid profile (risk factors for cardiovascular disease) were observed in lean PCOS patients. Rosiglitazone seemed to decrease elevated oxidative stress when compared with metformin treatment in lean PCOS patients.
Série Scientifique Scientific Series Determinants of Desired Career Paths among Canadian Engineers Determinants of Desired Career Paths among Canadian Engineers *

CIRANO Le CIRANO est une corporation privée à but non lucratif constituée en vertu de la Loi des compagnies du Québec. Le financement de son infrastructure et de ses activités de recherche provient des cotisations de ses organisations-membres, d=une subvention d=infrastructure du ministère de l=Industrie, du Commerce, de la Science et de la Technologie, de même que des subventions et mandats obtenus par ses équipes de recherche. La Série Scientifique est la réalisation d=une des missions que s=est données le CIRANO, soit de développer l=analyse scientifique des organisations et des comportements stratégiques. CIRANO is a private non-profit organization incorporated under the Québec Companies Act. Its infrastructure and research activities are funded through fees paid by member organizations, an infrastructure grant from the Ministère de l=Industrie, du Commerce, de la Science et de la Technologie, and grants and research mandates obtained by its research teams. The Scientific Series fulfils one of the missions of CIRANO: to develop the scientific analysis of organizations and strategic behaviour. Ce document est publié dans l=intention de rendre accessibles les résultats préliminaires de la recherche effectuée au CIRANO, afin de susciter des échanges et des suggestions. Les idées et les opinions émises sont sous l=unique responsabilité des auteurs, et ne représentent pas nécessairement les positions du CIRANO ou de ses partenaires. This paper presents preliminary research carried out at CIRANO and aims to encourage discussion and comment. The observations and viewpoints expressed are the sole responsibility of the authors. They do not necessarily represent positions of CIRANO or its partners. Cette recherche vise à étudier six orientations que les ingénieurs peuvent vouloir donner à leur carrière et à comprendre ce qui les amène à privilégier certains choix de carrière. Les possibilités de carrière retenues sont la voie de gestion, la voie technique, la voie de projet, la voie entreprenieuriale, la voie hybride et une nouvelle carrière. Une enquête par questionnaire a été réalisée auprès de 900 ingénieurs à travers le Québec, dont 403 femmes. Les résultats démontrent principalement que plusieurs des facteurs étudiés (principalement les facteurs individuels comme les ancres de carrière et la scolarité) permettent de distinguer efficacement les ingénieurs qui désirent poursuivre une carrière en gestion de ceux qui aspirent à d'autres voies de carrière. The goal of this research is to study five career paths available to engineers and to understand what leads them to prefer the management path to other career path …
A Multiple-Layer Machine Learning Architecture for Improved Accuracy in Sentiment Analysis

Twitter is an online micro-blogging platform through which one can explore the hidden valuable and delightful information about the current context at any point of time, which also serves as a data source to carry out sentiment analysis. In this paper, the sentiments of large amount of tweets generated from Twitter in the form of big data have been analyzed using machine learning algorithms. A multi-tier architecture for sentiment classification is proposed in this paper, which includes modules such as tokenization, data cleaning, preprocessing, stemming, updated lexicon, stopwords and emoticon dictionaries, feature selection and machine learning classifier. Unigram and bigrams have been used as feature extractors together with χ2 (Chi-squared) and Singular Value Decomposition for dimensionality reduction together with two model types (Binary and Reg), with four types of scaling methods (No scaling, Standard, Signed and Unsigned) and represented them in three different vector formats (TF-IDF, Binary and Int). Accuracy is considered as the evaluation standard for random forest and bagged trees classification methods. Sentiments were analyzed through tokenization and having several stages of pre-processing and several combinations of feature vectors and classification methods. Through which it was possible to achieve an accuracy of 84.14%. Obtained results conclude that, the proposed scheme gives a better accuracy when compared with existing schemes in the literature.
Neural substrates of visual stimulus-stimulus association in rhesus monkeys

Rhesus monkeys learned 10 visual stimulus-stimulus association, or paired associates. They then received bilateral removals of either the amygdaloid complex and underlying cortex, the hippocampal formation and underlying cortex, or both combined, or they were retained as unoperated controls. After surgery or rest, the monkeys were tested for their retention of the preoperatively learned set of paired associates, as well as for their ability to learn new associations of the same type. Both unoperated controls and hippocampectomized monkeys relearned the preoperatively trained set of paired associates almost immediately. By contrast, monkeys with amygdala removals were moderately retarded in relearning, and monkeys with combined amygdala and hippocampal ablations were severely retarded. When confronted with new sets of visual stimuli, monkeys with amygdala removals or hippocampal removals learned new sets of paired associates at the same rate as the controls, whereas monkeys with the combined ablation were again profoundly retarded. Only one monkey with the combined lesion was able to learn new stimulus-stimulus associations to criterion, and then only after extensive training, despite the ability of all three animals in this group to perform delayed matching-to-sample with the same stimuli and the same intraatrial delays as those used in the paired associate task. At the end of the main experiment, two of the unoperated controls received bilateral ablations of the rhinal cortex. These monkeys showed the same level of difficulty in learning new paired associates as the animals in the main experiment that had received the combined amygdala plus hippocampal ablations. The results implicate the medial temporal lobe, and particularly the rhinal cortex, in the formation of stimulus- stimulus associative memories.
Do Stock Prices Influence Corporate Decisions? Evidence from the Technology Bubble

Do firms issue stock when prices seem irrationally high? Do they invest or save the proceeds from the sale of overvalued stocks? Is value created or destroyed in the process? This paper uses a novel identification strategy to tackle these questions. We examine the capital investment, stock issuance, and cash savings behavior of financially constrained and unconstrained non-tech manufacturers ("old economy firms") around the 1990's technology bubble. Our results suggest that, because they relax financing constraints, high stock prices affect corporate policies. In particular, during the bubble, constrained non-tech firms issued equity in response to mispricing and used the proceeds to invest. They also saved part of those funds in their cash accounts. We do not find similar patterns for unconstrained non-tech firms, neither for tech firms. Our findings do not support the notion that managers systematically issue overvalued stocks and invest in ways that transfer wealth from new to old shareholders, destroying economic value. Rather, our evidence implies that what appears to be overvaluation in one sector of the economy may have welfare-increasing effects across other sectors.
The Role of Source Code within Program Summaries describing Maintenance Activities

This paper investigates the use and type of source code employed dur- ing program summaries which describe software maintenance tasks. The data consists of eighty-eight program summaries extracted from online developer mail- ing lists. The summaries were categorised into three themes, description of prob- lems, modifications and modification requests. Each theme was subdivided into five task types, adaptive, corrective, emergency, perfective and preventive. A sub- set of three categories from a content analysis schema have been isolated for this investigation, the three source code categories cover descriptions of single lines of code, code excerpts and blocks of code. The use of these three categories were examined between the theme groupings as well as within the themes, that is, dif- ferences between the task types. The results were not as frequent as expected. However a significant difference was found between the adaptive and perfective modification request summaries.
Determinants of Electronic Commerce in Pakistan: Preliminary Evidence from Small and Medium Enterprises

This study investigates the extent of e-commerce (EC) adoption along with the factors that predict EC adoption among 54 SMEs in Pakistan. The study found that 84% of the organizations have an Internet account; whereas 46% of the organizations have claimed average to above average adoption of EC (mean = 2.76). Several of the organizational factors such as organizational culture, management support and motivation to adopt EC along with technological and environmental factors were studied. Statistics further reveal that 59% of the organizations have either an in-house or vendor supported Web server and 67% of the surveyed organizations have a homepage. Factors such as perceived benefits, task variety, organizational culture and government support remain the significant predictors of EC adoption. All other factors including management support remained insignificant. Based upon findings, we made some recommendations to policy makers and relevant authorities for devising and implementation of a strategic plan t.
The relation between teaching the Arabic language using humour and reading comprehension at Elementary School in the Arab Sector in Israel

This research examines the extent to which the integration of humorous literary texts in teaching the Arabic language affects achievement in reading comprehension among Grade 4 pupils in the Arab sector in Israel. This research is the first one in the field. Research on the integration of humour in the study of Arabic language as first language does not exist so far. There are very few studies dealing with the integration of humour in the learning process of Arabic as a second language (only three were found). Hence, there are no studies dealing with the integration of humour in the educational field in the Israeli Arab sector. The research took place in one school in the Bedouin sector in the South of Israel. It was based on one experimental class and one control class The study examined the level of the pupils’ knowledge in all components of comprehension: explicit and implicit content, interpretation and integration, evaluating texts and drawing conclusions. The experimental classes studied six humorous stories whereas the control classes studied six stories without humour. The results of the experiment show that the achievements of pupils who learned comprehension using humorous stories was much higher than those in the control classes. In addition, a more positive learning environment was reported in the experimental classes.
Iterative thresholding compressed sensing MRI based on contourlet transform

Reducing the acquisition time is important for clinical magnetic resonance imaging (MRI). Compressed sensing has recently emerged as a theoretical foundation for the reconstruction of magnetic resonance images from undersampled k-space measurements, assuming those images are sparse in a certain transform domain. However, most real-world signals are compressible rather than exactly sparse. For example, the commonly used two-dimensional wavelet for compressed sensing MRI (CS-MRI) does not sparsely represent curves and edges. In this article, we introduce a geometric image transform, the contourlet, to overcome this shortage. In addition, the improved redundancy provided by the contourlet can successfully suppress the pseudo-Gibbs phenomenon, a tiresome artefact produced by undersampling of k-space, around the singularities of images. For numerical calculation, a simple but effective iterative thresholding algorithm is employed to solve l1 norm optimization for CS-MRI. Considering the recovered information and image features, we introduce three objective criteria, which are the peak signal-to-noise ratio (PSNR), mutual information and transferred edge information, to evaluate the performance of different image transforms. Simulation results demonstrate that contourlet-based CS-MRI can better reconstruct the curves and edges than traditional wavelet-based methods, especially at low k-space sampling rate.
Working Paper Superstitious Learning in Strategic Events : Theory and Evidence from Corporate Acquisitions

In this paper, the notion of superstitious learning is extended to encompass both causal ambiguity (Levit and March, 1988) and outcome ambiguity phenomena. I argue that superstitious learning is a particularly relevant problem in strategic events not only because causal linkages between actions and outcomes might be poorly inferred, but for the more basic reason that their performance outcomes are often very difficult to assess in objective ways. Experience accumulation, in these conditions, not only might not be helpful but could even hurt the learning process, with negative performance consequences. The conditions defining the boundaries of the phenomenon are then considered: two mitigating factors are identified in the heterogeneity of the stock of accumulated experience and in deliberate learning processes. I test these arguments with a sample of US bank mergers and find evidence that managers’ self-attributions of success in previous acquisitions is negatively related to the actual performance of the focal merger, and that this effect increases, rather than reducing, as they accumulate experience. Consistent with the theoretical arguments developed, the effect is significantly attenuated as the stock of experience becomes more heterogeneous and knowledge is systematically articulated and codified.
Design and analysis of adaptive migration intervals in parallel evolutionary algorithms

The migration interval is one of the fundamental parameters governing the dynamic behaviour of island models. Yet, there is little understanding on how this parameter affects performance, and how to optimally set it given a problem in hand. We propose schemes for adapting the migration interval according to whether fitness improvements have been found. As long as no improvement is found, the migration interval is increased to minimise communication. Once the best fitness has improved, the migration interval is decreased to spread new best solutions more quickly. We provide a method for analysing the expected running time and the communication effort, defined as the expected number of migrants sent. Example applications of this method to common example functions show that our adaptive schemes are able to compete with, or even outperform, the optimal fixed choice of the migration interval, with regard to running time and communication effort.
Comparison of EndoPredict and Oncotype DX Test Results in Hormone Receptor Positive Invasive Breast Cancer

Aim Several multigene expression-based tests offering prognostic and predictive information in hormone-receptor positive early breast cancer were established during the last years. These tests provide prognostic information on distant recurrences and can serve as an aid in therapy decisions. We analyzed the recently validated reverse-transcription-quantitative-real-time PCR-based multigene-expression Endopredict (EP)-test on 34 hormone-receptor positive breast-cancer cases and compared the EP scores with the Oncotype DX Recurrence-scores (RS) obtained from the same cancer samples. Methods Formalin-fixed, paraffin-embedded invasive breast-cancer tissues from 34 patients were analyzed by the EP-test. Representative tumor blocks were analyzed with Oncotype DX prior to this study. Tumor tissue was removed from unstained slides, total-RNA was isolated and EP-analysis was performed blinded to Oncotype DX results. Results Extraction of sufficient amounts of RNA and generation of valid EP-scores were possible for all 34 samples. EP classified 11 patients as low-risk and 23 patients as high-risk. RS Score defined 15 patients as low-risk, 10 patients as intermediate-risk in and 9 patients as high-risk. Major-discrepancy occurred in 6 of 34 cases (18%): Low-risk RS was classified as high-risk by EP in 6 cases. Combining the RS intermediate-risk and high-risk groups to a common group, the concordance between both tests was 76%. Correlation between continuous EP and RS-scores was moderate (Pearson-coefficient: 0.65 (p<0.01). Conclusion We observed a significant but moderate concordance (76%) and moderate correlation (0.65) between RS and EP Score. Differences in results can be explained by different weighting of biological motives covered by the two tests. Further studies are needed to explore the clinical relevance of discrepant test results with respect of outcome.
Functional diversity of microglia – how heterogeneous are they to begin with?

Microglia serve in the surveillance and maintenance, protection and restoration of the central nervous system (CNS) homeostasis. By their parenchymal location they differ from other CNS-associated myeloid cells, and by origin as well as functional characteristics they are also–at least in part–distinct from extraneural tissue macrophages. Nevertheless, microglia themselves may not comprise a uniform cell type. CNS regions vary by cellular and chemical composition, including white matter (myelin) content, blood–brain barrier properties or prevailing neurotransmitters. Such a micromilieu could instruct as well as require local adaptions of microglial features. Yet even cells within circumscribed populations may reveal some specialization by subtypes, regarding house-keeping duties and functional capacities upon challenges. While diversity of reactive phenotypes has been established still little is known as to whether all activated cells would respond with the same program of induced genes and functions or whether responder subsets have individual contributions. Preferential synthesis of a key cytokine could asign a master control to certain cells among a pool of activated microglia. Critical functions could be sequestered to discrete microglial subtypes in order to avoid interference, such as clearance of endogenous material and presentation of antigens. Indeed, several and especially a number of recent studies provide evidence for the constitutive and reactive heterogeneity of microglia by and within CNS regions. While such a principle of “division of labor” would influence the basic notion of “the” microglia, it could come with the practival value of addressing separate microglia types in experimental and therapeutic manipulations.