Miracle-dz/UniFAR-FTUs huggingface dataset:
Does Previous Hip Surgery Effect the Outcome of Tönnis Triple Periacetabular Osteotomy? Mid-Term Results

AbstractHip dysplasia (HD) is 1 of the major reasons of coxarthrosis. The goal of the treatment of HD by Tönnis triple pelvic osteotomy (TPAO) is to improve the function of hip joint while relieving pain, delaying and possibly preventing end-stage arthritis. The aim of this study is to compare the clinical and radiological results of TPAO to determine if previous surgery has a negative effect on TPAO.Patients operated with TPAO between 2005 and 2010, included in this study. Patients divided into 2 groups: primary acetabular dysplasia (PAD) and residual acetabular dysplasia (RAD). Prepostoperatively, hip range of motion, Harris hip score (HHS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) hip score, visual analog scores (VAS), impingement tests, and also the presence of Trendelenburg sign (TS) were investigated for clinical evaluation. For radiological analysis pre–postoperative, anterior–posterior (AP) pelvis and faux profile radiographs were used. Acetabular index, lateral center edge (LCE) angle, and Sharp angles were measured by AP pelvis; anterior center edge (ACE) angle were measured by faux profile radiography. All the clinical and radiological data of the groups were analyzed separately for the pre–postoperative scores also the amount of improvement in all parameters were analyzed.SPSS20 (SPSS Inc., Chicago, IL) was used for statistical analysis. Wilcoxon test, McNemar test, paired t tests, and Mann–Whitney U tests were used to compare the groups. P < 0.05 were defined as statistically significant.Study included 27 patients: 17 patients were in PAD and 10 patients were in RAD. The mean follow-up period was 6.2 years (5.2–10.3 years). In all patients, the radiological and the clinical outcomes were better after TPAO except the flexion of the hip parameter. When the patient groups were evaluated as pre–postoperatively, more statistically significant parameters were found in the PAD group when compared with RAD group. Extension, impingement, TS, VAS, HHS, WOMAC score parameters in clinical outcome and LCE, ACE, Sharp angle, coverage ratio in radiological results were significantly better in PAD group postoperatively but in RAD group; only extension, VAS, HHS, and WOMAC parameters were clinically and LCE and Coverage ratio were significantly different compared with the preoperative measurements. The change of the parameters that used for the evaluation of clinical and radiological results did not show a significant difference between groups.Our data suggest that TPAO can be performed on patients with HD for both groups. Although there were fewer parameters which changed significantly after TPAO in RAD patients; the improvement of radiological and clinical results was similar for groups. Further long-term follow-up studies with large number of patients are needed to determine the proper results of TPAO.
Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group (n = 60) and the lorazepam tablet treatment group (n = 59). Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (P = 0.029), the PSQI (P = 0.017), and wake after sleep onset (WASO; P = 0.008) scores and improved sleep architecture (P = 0.000–0.003) after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety.
A small-world brain functional network of Chinese characters processing with local functional cliques and long-distance connections

Chinese characters processing is a complex task involving word identification, phonologic assembly, semantic processing, and letter expression, etc. We built a brain functional network of Chinese characters processing (CCPBFN) with voxels in functional magnetic resonance imaging data as nodes, and significant functional connections among voxels as edges. The primary results revealed that the CCPBFN fell into the small-world networks category, which might reflect an optimal organization pattern for information processing. In a further study of the hierarchy, analyses suggested that voxels tended to connect with others in local regions to form highly interconnected cliques, and the hubs with long-distance connections joined the remote cliques into a whole. We proposed that the CCPBFN might be shaped by the complexity and neural dynamics of Chinese characters processing, which might be corresponding to the neural assemblies.
Recombinant human endostatin administered as a 28-day continuous intravenous infusion, followed by daily subcutaneous injections: a phase I and pharmacokinetic study in patients with advanced cancer.

BACKGROUND Endostatin is an endogenous collagen XVIII-fragment with anti-angiogenic properties and remarkable antitumor activity in mice. Preclinical data suggest that continuous low dose administration of endostatin is much more potent than intermittent dosing. The feasibility of this approach is tested in a phase I study. PATIENTS AND METHODS We determined the safety and pharmacokinetic profile of 4-week continuous intravenous infusion of recombinant human (rh)-endostatin, followed after an interval of 1 week by twice daily subcutaneous injections in patients with advanced cancer. Thirty-two patients received rh-endostatin in six dosing cohorts, ranging from 3.75 mg/m(2)/day to 120 mg/m(2)/day. Serum endostatin pharmacokinetics, toxicity and antitumor response were determined. RESULTS A total of 160 cycles were delivered without significant toxicities. Pharmacokinetic analysis showed a linear increase of steady-state serum endostatin concentrations with dose (i.v. r(2)=0.96; s.c. r(2)=0.99) reaching 300--1,000 ng/ml for the two highest doses, with considerable interpatient variation. The main pharmacokinetic values for both routes of administration were similar. The apparent steady-state concentration and AUC reached at 60--120 mg/m(2)/day were within the range expected to induce anti-angiogenic and antitumor effects based on preclinical tumor models. Although no objective responses were observed, two patients had long-lasting stable disease (defined as a tumor increase<100%). CONCLUSION rh-endostatin was safely administered both by continuous infusion and by twice daily subcutaneous injections up to 120 mg/m(2)/day. Predictable pK was seen in this dose range and the target endostatin levels were reached from 60 mg/m(2)/day and above.
Lower Bounds for Differential Privacy from Gaussian Width

We study the optimal sample complexity of a given workload of linear queries under the constraints of differential privacy. The sample complexity of a query answering mechanism under error parameter alpha is the smallest n such that the mechanism answers the workload with error at most alpha on any database of size n. Following a line of research started by Hardt and Talwar [STOC 2010], we analyze sample complexity using the tools of asymptotic convex geometry. We study the sensitivity polytope, a natural convex body associated with a query workload that quantifies how query answers can change between neighboring databases. This is the information that, roughly speaking, is protected by a differentially private algorithm, and, for this reason, we expect that a "bigger" sensitivity polytope implies larger sample complexity. Our results identify the mean Gaussian width as an appropriate measure of the size of the polytope, and show sample complexity lower bounds in terms of this quantity. Our lower bounds completely characterize the workloads for which the Gaussian noise mechanism is optimal up to constants as those having asymptotically maximal Gaussian width. Our techniques also yield an alternative proof of Pisier's Volume Number Theorem which also suggests an approach to improving the parameters of the theorem.
Beyond Q: Investment without Asset Prices

Empirical corporate finance studies often rely on measures of Tobin’s Q to control for “fundamental”determinants of investment. However, since Tobin’s Q is a good summary of investment behavior only under very stringent conditions, it is far better to instead use the underlying state variables directly. In this paper we show that under very general assumptions about the nature of technology and markets, these state variables are easily measurable and greatly improve the empirical fit of investment models. Even a general first or second order polynomial that does not rely on additional details about the nature of the investment problem accounts for a substantially larger fraction of the total variation in corporate investment than standard Q measures.
Severity Assessment of Lower Respiratory Tract Infection in Malawi: Derivation of a Novel Index (SWAT-Bp) Which Outperforms CRB-65

Objective To assess the validity of CRB-65 (Confusion, Respiratory rate >30 breaths/min, BP<90/60 mmHg, age >65 years) as a pneumonia severity index in a Malawian hospital population, and determine whether an alternative score has greater accuracy in this setting. Design Forty three variables were prospectively recorded during the first 48 hours of admission in all patients admitted to Queen Elizabeth Central Hospital, Malawi, for management of lower respiratory tract infection over a two month period (N = 240). Calculation of sensitivity and specificity for CRB-65 in predicting mortality was followed by multivariate modeling to create a score with superior performance in this population. Results Median age 37, HIV prevalence 79.9%, overall mortality 18.3%. CRB-65 predicted mortality poorly, indicated by the area under the ROC curve of 0.649. Independent predictors of death were: Male sex, “S” (AOR 2.6); Wasting, “W” (AOR 6.6); non-ambulatory, “A” (AOR 2.5); Temp >38°C or <35°C, “T” (AOR 3.2); BP<100/60, “Bp” (AOR 3.7). Combining these factors to form a severity index (SWAT-Bp) predicted mortality with high sensitivity and specificity (AUC: 0.867). Mortality for scores 0–5 was 0%, 3.3%, 7.4%, 29.2%, 61.5% and 87.5% respectively. A score ≥3 was 84% sensitive and 77% specific for mortality prediction, with a negative predictive value of 95.8%. Conclusion CRB-65 performs poorly in this population. The SWAT-Bp score can accurately stratify patients; ≤2 indicates non-severe infection (mortality 4.4%) and ≥3 severe illness (mortality 45%).
Multi-robot deployment from LTL specifications with reduced communication

In this paper, we develop a computational framework for fully automatic deployment of a team of unicycles from a global specification given as an LTL formula over some regions of interest. Our hierarchical approach consists of four steps: (i) the construction of finite abstractions for the motions of each robot, (ii) the parallel composition of the abstractions, (iii) the generation of a satisfying motion of the team; (iv) mapping this motion to individual robot control and communication strategies. The main result of the paper is an algorithm to reduce the amount of inter-robot communication during the fourth step of the procedure.
Does tiger parenting work in contemporary China? Exploring the relationships between parenting profiles and preschoolers’ school readiness in a Chinese context

ABSTRACT This study explored the relationships between parenting profiles and young children’s school readiness in urban China. Eighty-six pairs of Chinese parents completed the Chinese Parenting Style Questionnaire (CPSQ), and their children were administered the Bracken School Readiness Composite (BSRC; Bracken, B. A. (1998). Bracken basic concept scale: Revised. San Antonio, TX: Psychological Corporation. ) and Preschool and Primary Chinese Literacy Scale (PPCLS; Li, H. (1999). Development and validation of the Preschool and Primary Chinese Literacy Scale. Psychological Development and Education, 15, 18–24. ). A set of statistical analyses was conducted to explore the relationship between the three types of parenting profiles (supportive, tiger and easygoing) and children’s scores in BSRC and PPCLS, and four typical couples were invited to attend semi structured interviews. The results indicated that: (1) Inter-parental consistency in supportive parenting were associated with better children’s school readiness, but not for consistency in easygoing or tiger parenting; (2) Tiger mothers were not associated with better outcomes in either boys or girls; (3) Significant interaction effect was found between child gender and parenting profile. The findings have implications for the theoretical development of parental education and related programmes. Understanding the differentiated parenting styles and practices with boys and girls will help parents and educators to improve their educational practices.
An Examination of Intertrial Interval and Gender Influences on Sucrose Detection Thresholds Established by a Modified Staircase Procedure

The influence of intertrial interval durations ranging from 7 to 30 s upon sucrose detection thresholds of sixteen subjects was investigated by means of a modified staircase procedure with intertrial rinses. In addition, the influence of the sex of the subject was examined. Neither the intertrial interval nor the sex of the subject significantly affected sucrose detection thresholds. The results suggest that, in sucrose detection threshold studies using the present procedure, one can employ intertrial intervals as short as 7 s without significantly affecting the threshold value.
Teacher Concerns During Initial Implementation of a One-to-One Laptop Initiative at the Middle School Level

Abstract Many schools are initiating projects that place laptop computers into the hands of each student and teacher in the school. These projects entail a great deal of planning and investment by all involved. The teachers in these schools are faced with significant challenges as they prepare for teaching in classrooms where every student has a computer. Using the Concerns-Based Adoption Model of change, this study investigated the concerns of teachers in the early stages of a one-to-one laptop initiative. The results of the study indicate that teachers fall into two relatively well-defined categories in terms of their concerns regarding the innovation. The majority of teachers have genuine concerns about how the introduction of laptop computers into the school environment will impact them personally. A lesser number have concerns about how they will be able to best use the laptops to meet the needs of the students. Implications for professional development include differentiating training based on teacher concerns, ensuring teachers have a voice in the process and are well-informed of decisions pertaining to the adoption, and implementation of the innovation.
The Relationship Between Psychological Symptoms, Creativity, and Loneliness in Gifted Children

The aim of this study was to examine the relationship between psychological symptoms, creativity, and loneliness among gifted middle school students and to analyze gender difference in psychological symptoms. The study used a correlational design, consisting of 91 gifted middle school students. The Brief Symptom Inventory, the University of California, Los Angeles (UCLA) Loneliness Scale, and the Torrance Tests of Creative Thinking were used as data-collection instruments. The results showed that there was no significant difference between gifted female and male students in the Brief Symptom Inventory total score and subscales except in the depression subscale. In addition, the Brief Symptom Inventory including subscales was significantly and positively correlated with the UCLA Loneliness Scale. There was no significant correlation between the Torrance Tests of Creative Thinking and the other scales. Loneliness was found to be a significant predictor of psychological symptoms. The results of this study suggest that loneliness is a major factor for the psychological well-being of gifted students.
Conceptions of Research Methods Learning Among Psychology Undergraduates: A Q Methodology Study*

Abstract A range of conceptions held about research methods learning have previously been identified. This study aimed to examine in-depth shared conceptions among undergraduate psychology students. Utilizing Q methodology, which links both quantitative and qualitative methodologies to uncover the subjective viewpoints that a group of individuals hold toward a particular domain, participants ranked statements reflecting different conceptions of research methods learning. Ranks were then factor analyzed and four distinct profiles of student conceptions were identified, labelled, and described in qualitative detail: research methods as integral to psychology, research methods as a digression from psychology, research methods as disconnected from psychology, and research methods as beneficial to psychology. Some of the perspectives displayed a clear understanding about the reasons for undertaking research and learning about research methods in psychology, whereas other standpoints saw research as being something that was difficult to relate to the practice of psychology. Findings are considered in terms of how some conceptions appear to be more beneficial or problematic to hold than others and recommendations are made to educators about how they could support students to change their views.
Examining the effects of knowledge, attitude and behaviour on information security awareness: A case on SME

The role and importance of information security policy is gaining its popularity in many large organisations. However, this is not the case for SMEs as developing and adopting information security policy requires a lot of time and resources. Lack of awareness, thus, exposes organisation to significant risk in ensuring security and protection of organisational assets. This paper reports awareness of information security at a SME in Malaysia. The research aims to establish the relationship between knowledge, attitude and behaviour and information security awareness. A survey questionnaire was used to collect data about information security awareness. Partial-least square was used for data analysis. The findings present information security awareness of employees indicating attitude and behaviour found to be significantly influence confidentiality, integrity, and availability (CIA) of business information.
Enhanced Extracellular Glutamate and Dopamine in the Ventral Pallidum of Alcohol-Preferring AA and Alcohol-Avoiding ANA Rats after Morphine

The purpose of the present study was to investigate the role of ventral pallidal opioidergic mechanisms in the control of ethanol intake by studying the effects of acute administration of morphine on the levels of GABA, glutamate, and dopamine in the ventral pallidum. The study was conducted using the alcohol-preferring Alko Alcohol (AA) and alcohol-avoiding Alko Non-Alcohol (ANA) rat lines that have well-documented differences in their voluntary ethanol intake and brain opioidergic systems. Therefore, examination of neurobiological differences between the lines is supposed to help to identify the neuronal mechanisms underlying ethanol intake, since selection pressure is assumed gradually to lead to enrichment of alleles promoting high or low ethanol intake, respectively. The effects of an acute dose of morphine (1 or 10 mg/kg s.c.) on the extracellular levels of GABA and glutamate in the ventral pallidum were monitored with in vivo microdialysis. The concentrations of GABA and glutamate in the dialyzates were determined with a high performance liquid chromatography system using fluorescent detection, while electrochemical detection was used for dopamine. The levels of glutamate in the rats injected with morphine 1 mg/kg were significantly above the levels found in the controls and in the rats receiving morphine 10 mg/kg. Morphine 10 mg/kg also increased the levels of dopamine. Morphine could not, however, modify the levels of GABA. The rat lines did not differ in any of the effects of morphine. The data suggest that the glutamatergic and dopaminergic systems in the ventral pallidum may mediate some effects of morphine. Since there were no differences between the AA and ANA lines, the basic hypothesis underlying the use of the genetic animal model suggests that the effects of morphine detected probably do not underlie the different intake of ethanol by the lines and contribute to the control of ethanol intake in these animals.
Noisy spit: parental noncompliance with child salivary cortisol sampling.

Studies assessing hypothalamic-pituitary-adrenal (HPA) axis functioning in young children commonly involve parental collection of salivary cortisol in ambulatory settings. However, no data are available on the compliance of parents in collecting ambulatory measures of children's salivary cortisol. This study examined the effects of parental compliance on the cortisol awakening response (CAR) and diurnal cortisol slopes in a sample of preschool-age children (ages 3-5). Eighty-one parents were instructed to collect their child's salivary cortisol samples upon their child's waking, 30 and 45 min post-waking and before bedtime on two weekdays. Subjective parental compliance was assessed using parent-report, and objective parental compliance was assessed using an electronic monitoring device. Rates of compliance were higher based on parent-report than electronic monitoring. Parental noncompliance as indicated by electronic monitoring was associated with higher waking cortisol and lower CAR. Findings suggest the need to incorporate electronic monitoring of parental compliance into developmental neuroendocrine research, especially when assessing the CAR.
“Babies come when they are ready”: Women’s experiences of resisting the medicalisation of prolonged pregnancy

Being pregnant beyond one’s estimated due date is a relatively common experience and requires complex decisions about whether to induce labour or wait for spontaneous onset. We report a qualitative study undertaken in the UK in 2016. We interviewed fifteen women and eleven more took part in an online focus group. Using thematic analysis, resistance to the medicalisation of prolonged pregnancy was identified as a strong theme. Drawing on the work of Armstrong and Murphy, we identify both conceptual and behavioural resistance in the accounts of women who accepted, delayed or declined induction of labour. Experiential knowledge played a key role in resistance, but women found this was devalued. Some healthcare staff used risk discourse to pressure women to comply with induction protocols but were unwilling to engage in discussion. The social context provided further pressure to produce a baby ‘on time’, with induction normalised as the way to manage prolonged pregnancy. Online spaces provided additional information and support for women to question the medicalisation of prolonged pregnancy. We end by considering the implications for policies of choice and agency in maternity care as well as the need for additional social support for women who are ‘overdue’.