Miracle-dz/UniFAR-FTUs huggingface dataset:
Market Bubbles and Crashes as an Expression of Tension between Social and Individual Rationality: Experiments

We investigate the claim that social rationality explains the emergence of one type of bubble in competitive asset markets that we shall refer to as “credit market bubble,” and that individual rationality explains the subsequent crash. The bubble is defined as a situation where (i) the debt is priced above its intrinsic value and (ii) the debt is rolled over even though each creditor should cash in as it is commonly known that the debtor would never be able to repay the debt at face value. Building on evidence from behavioral game theory, we conjecture that credit market bubbles emerge whenever the debtor’s payment ability, although never su cient, grows over time. As such, bubbles are beneficial, even if they eventually lead to crashes which cause re-distribution of wealth away from those who ride the bubble too long. We argue that this captures the essence of many financial bubbles alleged to have been observed in the real world. Experimental data confirm the emergence of bubbles in this setting. The bubbles are robust – they re-emerge upon replication – and decay can be avoided by adding noise, e.g., through random introduction of (informed) newcomers. The presence of financial markets increases the overall beneficial e↵ects of the bubbles. Prices always remain above levels predicted by conventional asset pricing theory. Nevertheless, they exhibit properties of (informational) e ciency. Among others, prices cannot be used to predict the length of the bubble, but correlate with the payo↵s that the claims eventually generate.
Identification of miR-29a as a novel biomarker for lumpy skin disease virus exposure in cattle

ABSTRACT Micro RNAs (miRNAs) have been implicated in the regulation of maturation, proliferation, differentiation, and activation of immune cells. In this study, we demonstrated that miR-29a antagonizes IFN-γ production at early times post-LSDV infection in cattle. miR-29a was predicted to target upstream IFN-γ regulators, and its inhibition resulted in enhanced IFN-γ production in sensitized peripheral blood mononuclear cells (PBMCs). Further, stimulation of PBMCs with LSDV antigen exhibited lower levels of miR-29a, concomitant with a potent cell-mediated immune response (CMI), characterized by an increase in LSDV-specific CD8+ T cell counts and enhanced levels of IFN-γ, which eventually facilitated virus clearance. In addition, a few immunocompromised cattle (developed secondary LSDV infection at ~ 6 months) that failed to mount a potent cell-mediated immune response, were shown to maintain higher miR-29a levels. Furthermore, as compared to the sensitized crossbred cattle, PBMCs from sensitized Rathi (a native Indian breed) animals exhibited lower levels of miR-29a along with an increase in CD8+ T cell counts and enhanced levels of IFN-γ. Finally, we analysed that a ≥ 60% decrease in miR-29a expression levels in the PBMCs of sensitized cattle correlated with a potent CMI response. In conclusion, miR-29a expression is involved in antagonizing the IFN-γ response in LSDV-infected cattle and may serve as a novel biomarker for the acute phase of LSDV infection, as well as predicting the functionality of T cells in sensitized cattle. In addition, Rathi cattle mount a more potent CMI response against LSDV than crossbred cattle.
Mobile Robot with Preliminary-announcement and Indication Function of Forthcoming Operation using Flat-panel Display

This research aims to propose the method and equipment to preliminary-announce and indicate the surrounding people both the speed of motion and the direction of motion of the mobile robot that moves on a two-dimensional plane. This paper discusses the mobile robot PMR-6, in which the liquid crystal display (LCD) is set up on the mobile unit, and the state of operation at 1.5 s before the actual motion is indicated. The basis of the content to display is 'arrow' considering the intelligibility for people even at first sight. The speed of motion is expressed as the size (length and width) of the arrow and its color based on traffic signal. The direction of motion is described with the curved condition of the arrow. The characters of STOP are displayed in red in case of stop. The robot was exhibited to the 2005 International Robot Exhibition held in Tokyo. About 200 visitors answered to the questionnaires. The average of five-stage evaluation is 3.56 and 3.97 points on the speed and on the direction respectively, so the method and expression were evaluated comparatively intelligible. As for the gender, the females appreciated about the speed of motion than the males on the whole. Concerning the age, some of the younger age and the upper age admired highly about the direction of motion than the middle age.
String field theory vertices, integrability and boundary states

We study Neumann coefficients of the various vertices in the Witten’s open string field theory (SFT). We show that they are not independent, but satisfy an infinite set of algebraic relations. These relations are identified as so-called Hirota identities. Therefore, Neumann coefficients are equal to the second derivatives of tau-function of dispersionless Toda Lattice hierarchy (this tau-function is just a partition sum of normal matrix model). As a result, certain two-vertices of SFT are identified with the Neumann boundary states on an arbitrary curve. We further analyze a class of SFT surface states, which can be re-written in the closed string language in terms of boundary states. This offers a new correspondence
Experience with daclizumab in liver transplantation: renal transplant dosing without calcineurin inhibitors is insufficient to prevent acute rejection in liver transplantation.

BACKGROUND Daclizumab is a monoclonal antibody directed against the alpha chain of the interleukin 2 receptor. We review our experience with the use of daclizumab in liver transplant recipients. METHODS Thirty-two patients were given daclizumab as induction therapy in the setting of hepatic transplantation. Seven of these patients were enrolled in a pilot study to determine the efficacy of daclizumab in conjunction with corticosteroids and mycophenolate mofetil without the initial use of calcineurin inhibitors (CI). The remaining 25 patients received daclizumab, mycophenolate mofetil, and steroids, with the institution of CI generally within the first postoperative week. The majority of these patients (n = 17) had some degree of renal insufficiency. RESULTS The pilot study was halted after the first seven patients were enrolled because of an unacceptably high rate of rejection (7/7 = 100%). The patients outside of this pilot study, however, had a much lower rate of rejection (36%). The incidence and severity of rejection correlated with the delay in institution of CI. The described dosing schedule resulted in subtherapeutic daclizumab levels in liver transplant recipients. CONCLUSIONS Daclizumab used in liver transplant recipients without any CI was ineffective and can potentially lead to steroid-resistant rejection. The dosing regimen used in renal transplant recipients is most likely insufficient for liver transplant patients. However, daclizumab can be used safely in patients with preexisting or postoperative renal dysfunction in conjunction with low doses of CI given within the first week postoperatively.
Semantic Diversity Accounts for the “Missing” Word Frequency Effect in Stroke Aphasia: Insights Using a Novel Method to Quantify Contextual Variability in Meaning

Word frequency is a powerful predictor of language processing efficiency in healthy individuals and in computational models. Puzzlingly, frequency effects are often absent in stroke aphasia, challenging the assumption that word frequency influences the behavior of any computational system. To address this conundrum, we investigated divergent effects of frequency in two comprehension-impaired patient groups. Patients with semantic dementia have degraded conceptual knowledge as a consequence of anterior temporal lobe atrophy and show strong frequency effects. Patients with multimodal semantic impairments following stroke (semantic aphasia [SA]), in contrast, show little or no frequency effect. Their deficits arise from impaired control processes that bias activation toward task-relevant aspects of knowledge. We hypothesized that high-frequency words exert greater demands on cognitive control because they are more semantically diverse—they tend to appear in a broader range of linguistic contexts and have more variable meanings. Using latent semantic analysis, we developed a new measure of semantic diversity that reflected the variability of a word's meaning across different context. Frequency, but not diversity, was a significant predictor of comprehension in semantic dementia, whereas diversity was the best predictor of performance in SA. Most importantly, SA patients did show typical frequency effects but only when the influence of diversity was taken into account. These results are consistent with the view that higher-frequency words place higher demands on control processes, so that when control processes are damaged the intrinsic processing advantages associated with higher-frequency words are masked.
Pocket hematoma after pacemaker or implantable cardioverter defibrillator surgery: influence of patient morbidity, operation strategy, and perioperative antiplatelet/anticoagulation therapy.

STUDY OBJECTIVES Pocket hematoma is a common complication after pacemaker or implantable cardioverter defibrillator (ICD) implantation. Thus, we investigated the influence of patient comorbidity, implantation strategy, operator experience, antiplatelet therapy, and anticoagulation therapy on hematoma rate. DESIGN Between 1990 and 2002, a total of 3,164 devices (pectoral pacemakers, 2,792; ICDs, 372) were implanted at our institution. Predictors of hematoma occurrence were determined prospectively and were analyzed by multivariate regression analysis. Operator experience was graded by individual implantation number, as follows: low, < 50; medium, 50 to 100; and high, > 100. RESULTS The incidence of pocket hematoma was 4.9%, leading to prolonged hospitalization in 2.0% of all patients. Reoperation for pocket hematoma was required in 1.0% of patients. High-dose heparinization (hazard ratio [HR], 4.2), combined acetylsalicylic acid (ASA)/thienopyridine treatment after coronary stenting (HR, 5.2), and low operator experience (HR, 1.6) were independently predictive of hematoma development. Therapy with ASA alone did not increase the hematoma rate compared to patients who did receive antiplatelet or anticoagulation therapy (3.1% vs 2.5%, respectively; difference not significant). In patients with nonvalvular atrial fibrillation, postoperative high-dose heparinization substantially increased the hematoma rate (10.7% vs 2.9%, respectively; p < 0.001) without reducing the rate of arterial embolism within the first month after implantation (0.18% vs 0.21%, respectively; difference not significant). The infection rate (0.28% within 3 months after implantation) was not influenced by the presence of the pocket hematoma. CONCLUSIONS The use of high-dose heparinization and combined ASA/thienopyridine treatment are highly predictive for the occurrence of intraoperative bleeding and pocket hematoma in patients who have undergone pacemaker and ICD surgery. We propose recommendations for the management of antiplatelet and anticoagulation therapy in patients undergoing these interventions.
The Solubility and Metal-silicate Partitioning of Some Highly Siderophile Elements: Implications for Core-formation and Planetary Accretion

Understanding Earth’s accretion and primary differentiation is a long-standing goal of geology. The segregation of FeNi metal from molten silicate to form Earth’s core is expected to deplete and fractionate the highly siderophile elements (HSEs). Estimates of the primitive upper mantle (PUM) composition however, reveal only modest HSE depletions and chondritic element ratios. Past experiments to determine if the mantle composition is set by high-temperature metal-silicate equilibrium have involved measuring the solubility of HSEs in silicate melt at conditions more reducing than the iron-wustite (IW) buffer. Accurate determination of solubilities at such conditions has been hindered by the formation of dispersed metal inclusions; this work describes methods to circumvent the problem. Results of three separate studies are presented which document the solubility of Re, Pt and Au in molten silicate which is demonstrably nugget-free. Data obtained from experiments done at 0.1 MPa–2 GPa, 1573–2573 K and ~ IW -1.5 to +3 reveal: 1) Re, Pt and Au solubility increases with increasing temperature, 2) Re solubility
The condition number of a randomly perturbed matrix

Let M be an arbitrary <i>n</i> by <i>n</i> matrix. We study the conditionnumber a random perturbation M+N<sub>n</sub> of M, where N<sub>n</sub> is arandom matrix. It is shown that, under very general conditions on M and M<sub>n</sub>, the condition number of M+N<sub>n</sub> is polynomial in <i>n</i>with very high probability. The main novelty here is that we allow N<sub>n</sub> to have discrete distribution.
Dengue virus infects mouse cultured neurons but not astrocytes

Cultures of mouse brain cells containing a high proportion either neurons or astrocytes were inoculated with various strains of dengue virus. At analysis by double immunofluorescence, all strains of dengue virus studied were tropic for neurons. In no case were the astrocytes infected. Only ∼10% of all neurons were infected, suggesting that the virus may enter the cell through a membrane receptor present only in a subgroup of neurons. © 1994 Wiley‐Liss, Inc.
Service user and caregiver involvement in mental health system strengthening in low- and middle-income countries: a cross-country qualitative study

Aims. The aims of this paper are to: (i) explore the experiences of involvement of mental health service users, their caregivers, mental health centre heads and policy makers in mental health system strengthening in three low- and middle-income countries (LMICs) (Ethiopia, Nepal and Nigeria); (ii) analyse the potential benefits and barriers of such involvement; and (iii) identify strategies required to achieve greater service user and caregiver participation. Methods. A cross-country qualitative study was conducted, interviewing 83 stakeholders of mental health services. Results. Our analysis showed that service user and caregiver involvement in the health system strengthening process was an alien concept for most participants. They reported very limited access to direct participation. Stigma and poverty were described as the main barriers for involvement. Several strategies were identified by participants to overcome existing hurdles to facilitate service user and caregiver involvement in the mental health system strengthening process, such as support to access treatment, mental health promotion and empowerment of service users. This study suggests that capacity building for service users, and strengthening of user groups would equip them to contribute meaningfully to policy development from informed perspectives. Conclusion. Involvement of service users and their caregivers in mental health decision-making is still in its infancy in LMICs. Effective strategies are required to overcome existing barriers, for example making funding more widely available for Ph.D. studies in participatory research with service users and caregivers to develop, implement and evaluate approaches to involvement that are locally and culturally acceptable in LMICs.
Molecular mechanisms of cell–cell spread of intracellular bacterial pathogens

Several bacterial pathogens, including Listeria monocytogenes, Shigella flexneri and Rickettsia spp. , have evolved mechanisms to actively spread within human tissues. Spreading is initiated by the pathogen-induced recruitment of host filamentous (F)-actin. F-actin forms a tail behind the microbe, propelling it through the cytoplasm. The motile pathogen then encounters the host plasma membrane, forming a bacterium-containing protrusion that is engulfed by an adjacent cell. Over the past two decades, much progress has been made in elucidating mechanisms of F-actin tail formation. Listeria and Shigella produce tails of branched actin filaments by subverting the host Arp2/3 complex. By contrast, Rickettsia forms tails with linear actin filaments through a bacterial mimic of eukaryotic formins. Compared with F-actin tail formation, mechanisms controlling bacterial protrusions are less well understood. However, recent findings have highlighted the importance of pathogen manipulation of host cell–cell junctions in spread. Listeria produces a soluble protein that enhances bacterial protrusions by perturbing tight junctions. Shigella protrusions are engulfed through a clathrin-mediated pathway at ‘tricellular junctions’—specialized membrane regions at the intersection of three epithelial cells. This review summarizes key past findings in pathogen spread, and focuses on recent developments in actin-based motility and the formation and internalization of bacterial protrusions.
Leukocytes Enhance Inflammatory and Catabolic Degenerative Changes in the Intervertebral Disc After Endplate Fracture In Vitro Without Infiltrating the Disc

Study Design. An established rabbit intervertebral disc (IVD)/endplate explant fracture model was extended with physiologic post-traumatic dynamic loading (PTDL) and coculturing of peripheral blood mononuclear cells (PBMCs). Objective. The aim of this study was to quantify the effects of PTDL and of cocultured PBMCs on post-traumatic disc degeneration (DD) and to determine whether PTDL facilitates homing of PBMC to fractured IVD/endplates. Summary of Background Data. DD is associated with endplate fracture. In vivo studies suggest a key role of immune cells in the pathogenesis of DD. However, the complexity of in vivo systems impedes the investigation of single factors governing the pathogenesis. Methods. Seventy-two IVD/endplate specimens were divided into 4 groups. In group A, endplate fractures were induced with a high-velocity axial load and exposed to PTDL in coculture with PBMCs for 14 days. Group A was compared with 3 control groups, with single-factor removal, in order to assess the relative contribution of PTDL (group B), PBMCs (group C), and endplate fracture (group D) to the biological response of the IVD. Disc gene transcription and serum nitric oxide (NO) serum concentration were measured to investigate differences in anabolism, catabolism, and inflammatory response between the groups. Changes in matrix composition and disc structure were assessed histologically. Results. PBMCs did not home to fractured IVDs, with or without PTDL. Group A compared with group D showed an enhanced transcription of anabolic, catabolic, and pro-inflammatory genes during the entire experiment, and an increased NO concentration for the first 3 days. Changes typical for DD were also found in histological sections. Group A compared with group C showed significant increases in catabolic and pro-inflammatory gene transcription after at least 7 days. No differences were found between groups A and B. Conclusion. Trauma induces degenerative changes; PTDL neither aggravates nor ameliorates this response. Although PBMCs do not infiltrate the disc, they aggravate the degenerative changes. Level of Evidence: N/A
Live Streaming in P2P and Hybrid P2P-Cloud Environments for the Open Internet

Peer-to-Peer (P2P) live media streaming is an emerging technology that reduces the barrier to stream live events over the Internet. However, providing a high quality media stream using P2P overlay networks is challenging and gives raise to a number of issues: (i) how to guarantee quality of the service (QoS) in the presence of dynamism, (ii) how to incentivize nodes to participate in media distribution, (iii) how to avoid bottlenecks in the overlay, and (iv) how to deal with nodes that reside behind Network Address Translators gateways (NATs). In this thesis, we answer the above research questions in form of new algorithms and systems. First of all, we address problems (i) and (ii) by presenting our P2P live media streaming solutions: Sepidar, which is a multiple-tree overlay, and GLive, which is a mesh overlay. In both models, nodes with higher upload bandwidth are positioned closer to the media source. This structure reduces the playback latency and increases the playback continuity at nodes, and also incentivizes the nodes to provide more upload bandwidth. We use a reputation model to improve participating nodes in media distribution in Sepidar and GLive. In both systems, nodes audit the behaviour of their directly connected nodes by getting feedback from other nodes. Nodes who upload more of the stream get a relatively higher reputation, and proportionally higher quality streams. To construct our streaming overlay, we present a distributed market model inspired by Bertsekas auction algorithm, although our model does not rely on a central server with global knowledge. In our model, each node has only partial information about the system. Nodes acquire knowledge of the system by sampling nodes using the Gradient overlay, where it facilitates the discovery of nodes with similar upload bandwidth. We address the bottlenecks problem, problem (iii), by presenting CLive that satisﬁes real-time constraints on delay between the generation of the stream and its actual delivery to users. We resolve this problem by borrowing some resources (helpers) from the cloud, upon need. In our approach, helpers are added on demand to the overlay, to increase the amount of total available bandwidth, thus increasing the probability of receiving the video on time. As the use of cloud resources costs money, we model the problem as the minimization of the economical cost, provided that a set of constraints on QoS is satisﬁed. Finally, we solve the NAT problem, problem (iv), by presenting two NAT-aware peer sampling services (PSS): Gozar and Croupier. Traditional gossip-based PSS breaks down, where a high percentage of nodes are behind NATs. We overcome this problem in Gozar using one-hop relaying to communicate with the nodes behind NATs. Croupier similarly implements a gossip-based PSS, but without the use of relaying.
On query result diversification

In this paper we describe a general framework for evaluation and optimization of methods for diversifying query results. In these methods, an initial ranking candidate set produced by a query is used to construct a result set, where elements are ranked with respect to relevance and diversity features, i.e., the retrieved elements should be as relevant as possible to the query, and, at the same time, the result set should be as diverse as possible. While addressing relevance is relatively simple and has been heavily studied, diversity is a harder problem to solve. One major contribution of this paper is that, using the above framework, we adapt, implement and evaluate several existing methods for diversifying query results. We also propose two new approaches, namely the Greedy with Marginal Contribution (GMC) and the Greedy Randomized with Neighborhood Expansion (GNE) methods. Another major contribution of this paper is that we present the first thorough experimental evaluation of the various diversification techniques implemented in a common framework. We examine the methods' performance with respect to precision, running time and quality of the result. Our experimental results show that while the proposed methods have higher running times, they achieve precision very close to the optimal, while also providing the best result quality. While GMC is deterministic, the randomized approach (GNE) can achieve better result quality if the user is willing to tradeoff running time.