Miracle-dz/UniFAR-FTUs huggingface dataset:
Oculomotor learning revisited: a model of reinforcement learning in the basal ganglia incorporating an efference copy of motor actions

In its simplest formulation, reinforcement learning is based on the idea that if an action taken in a particular context is followed by a favorable outcome, then, in the same context, the tendency to produce that action should be strengthened, or reinforced. While reinforcement learning forms the basis of many current theories of basal ganglia (BG) function, these models do not incorporate distinct computational roles for signals that convey context, and those that convey what action an animal takes. Recent experiments in the songbird suggest that vocal-related BG circuitry receives two functionally distinct excitatory inputs. One input is from a cortical region that carries context information about the current “time” in the motor sequence. The other is an efference copy of motor commands from a separate cortical brain region that generates vocal variability during learning. Based on these findings, I propose here a general model of vertebrate BG function that combines context information with a distinct motor efference copy signal. The signals are integrated by a learning rule in which efference copy inputs gate the potentiation of context inputs (but not efference copy inputs) onto medium spiny neurons in response to a rewarded action. The hypothesis is described in terms of a circuit that implements the learning of visually guided saccades. The model makes testable predictions about the anatomical and functional properties of hypothesized context and efference copy inputs to the striatum from both thalamic and cortical sources.
Molecular targeted therapy for biliary tract malignancy: defining the target.

Malignancies of the biliary tract are rare, diagnosed in approximately 9,000 patients each year in the United States (1). Unfortunately, most patients present with advanced disease. Of the small subset who present with resectable (and thus potentially curable) disease, many experience recurrence (2), reinforcing the fact that a multidisciplinary approach to these cancers is critical. Traditionally, our success with medical therapy for patients with locally advanced or metastatic disease has been poor.
A comparison of new bone formation in patients with ankylosing spondylitis and patients with diffuse idiopathic skeletal hyperostosis: a retrospective cohort study over six years.

OBJECTIVE Ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH) are both characterized by new bone formation in the spine but presumably have a different pathogenesis. This study was undertaken to compare the natural course of new bone formation in AS and DISH. METHODS Lateral radiographs of the cervical and lumbar spine from AS and DISH patients obtained at ≥2 time points within 6 years were analyzed to quantify osteophyte development. Radiographs were scored in a blinded manner by 2 readers using the modified Stoke AS Spine Score (mSASSS). Bone spurs were categorized as having an angle of <45° or >45°. RESULTS AS patients (n = 146) were younger than DISH patients (n = 141) (mean ± SD 54.2 ± 12.3 years versus 60.3 ± 7.7 years). Symptom duration (mean ± SD) was 23.6 ± 11.2 years in AS patients and 21.6 ± 12.4 years in DISH patients. The mSASSS at baseline was lower in DISH patients (mean ± SD 14.3 ± 6.7) than in AS patients (20.5 ± 14.5) but had increased by a similar amount at followup (3.3 ± 4.2 versus 4.1 ± 9.5). The mean mSASSS progression rate per year (1.3 units) was also comparable. The mean ± SD number of syndesmophytes per patient was higher in AS (5.7 ± 5.5) than DISH (2.7 ± 2.8) patients (P < 0.001), while degenerative bone spurs (mean ± SD) were more frequent in DISH (1.4 ± 1.8) than AS (1.0 ± 1.4) patients. AS patients developed more new bone spurs with an angle of <45° than >45° per patient (mean ± SD 2.1 ± 2.7 versus 0.6 ± 0.9) (P < 0.001), while similar amounts of both types of bone formation were seen in DISH patients. CONCLUSION Our findings indicate that the rates of new bone formation in AS and DISH are largely similar. Both groups show osteophyte development, but as expected, syndesmophytes are more frequent in AS patients while DISH patients have more degenerative bone spurs. The nature of the different mechanisms of bone formation needs further study.
Arrangements, Milnor Fibers and Polar Curves

We describe a new relation between the topology of hyperplane arrangements, Milnor fibers and global polar curves, via the affine Lefschetz theory developped by A. N\'emethi. In particular, we improve some results due to Orlik and Terao (see Math. Ann. 301(1995)) and complete/clarify a proof by Randell concerning the minimality of hyperplane arrangements (see math.AT/0011101).
Investigating Grade 8 Students' Conceptions of 'Energy' and Related Concepts

This study intends to elicit grade 8 students’ understanding of ‘energy’ concept and explore the extent to which students can link their theoretical knowledge with the novel situations. The sample consists of totally 171 grade 8 students drawn randomly from nine cohort primary schools in Erzurum. To collect data, researchers developed a concept test comprising of 18 multiple-choice questions. The results revealed that because of the numerous related conceptions with regard to ‘energy’ concept, students had difficulty in comprehending the ‘energy’ concept and tended to exploit these related concepts in place of ‘energy’ concept. Moreover, taking into consideration the students’ alternative conceptions drawn out by the current study, a sample conceptual change text is proposed to remedy them.
Spectral cues utilized in the localization of sound in the median sagittal plane.

A series of experiments was carried out to further elucidate the role of spectral cues in locating sounds in the median sagittal plane (MSP). Broadband noise bursts, generated at ±30°, ±15°, and O° re aural axis, were recorded via microphones placed in the external ear canals of 8 Ss. When these recorded sounds were played back dichotically through headphones, they were perceived as originating from the loudspeakers, not the headphones. In fact, Ss could identify that loudspeaker which originally generated the sound nearly as accurately as they could when listening under free‐field conditions. Analysis of the spectra of these recorded sounds revealed a notch in the frequency response curves which migrated toward the lower frequencies as the sound source was moved from above to below the aural axis. This feature of the spectrum may well be important for accuracy in locating sounds emanating from the frontal segment of the MSP. Four Ss were given additional tests to find out whether they could locate sounds.
Factors associated with length of stay and the risk of readmission in an acute psychiatric inpatient facility: a retrospective study

Objective: This study was to investigate factors influencing the length of stay and predictors for the risk of readmission at an acute psychiatric inpatient unit. Method: Two comparative studies were embedded in a retrospective cross-sectional clinical file audit. A randomly selected 226 episodes of admissions including 178 patients during a twelve-month period were reviewed. A total of 286 variables were collected and analysed. A case control study was employed in the study of length of stay. A retrospective cohort study was used to investigate the predictors for the risk of readmission. Results: Logistic regression analyses showed that 10 variables were associated with length of stay. Seclusion during the index admission, accommodation problems and living in an area lacking community services predicted longer stay. During the follow-up period 82 patients (46%) were readmitted. Cox regression analyses showed 9 variables were related to the risk of readmission. Six of these variables increased the risk of readmission, including history of previous frequent admission, risk to others at the time of the index admission and alcohol intoxication. More active and assertive treatment in the community post-discharge decreased the risk of readmission. Conclusions: Length of stay is multifactorially determined. Behavioural manifestations of illness and lack of social support structures predicted prolonged length of stay. Good clinical practice did not necessarily translate to a shorter length of stay. Therefore, length of stay is predictable, but not readily modifiable within the clinical domain. Good clinical practice within the community following discharge likely reduces the risk of readmission. Quality of inpatient care does not influence the risk of readmission, which therefore raises a question about the validity of using the rate of readmission as an outcome measure of psychiatric inpatient care.
Assessing the Challenges in the Application of Potential Probiotic Lactic Acid Bacteria in the Large-Scale Fermentation of Spanish-Style Table Olives

This work studies the inoculation conditions for allowing the survival/predominance of a potential probiotic strain (Lactobacillus pentosus TOMC-LAB2) when used as a starter culture in large-scale fermentations of green Spanish-style olives. The study was performed in two successive seasons (2011/2012 and 2012/2013), using about 150 tons of olives. Inoculation immediately after brining (to prevent wild initial microbiota growth) followed by re-inoculation 24 h later (to improve competitiveness) was essential for inoculum predominance. Processing early in the season (September) showed a favorable effect on fermentation and strain predominance on olives (particularly when using acidified brines containing 25 L HCl/vessel) but caused the disappearance of the target strain from both brines and olives during the storage phase. On the contrary, processing in October slightly reduced the target strain predominance on olives (70–90%) but allowed longer survival. The type of inoculum used (laboratory vs. industry pre-adapted) never had significant effects. Thus, this investigation discloses key issues for the survival and predominance of starter cultures in large-scale industrial fermentations of green Spanish-style olives. Results can be of interest for producing probiotic table olives and open new research challenges on the causes of inoculum vanishing during the storage phase.
Travel Choice with No Alternative

Land use is expected to have a two-tiered effect on reducing automobile dependence. One is to enhance access to choices and the other to influence modal shifts away from driving. Existing studies have focused primarily on the second-tier effect. This article presents an empirical study of automobile dependence with emphasis on the identification of the first-tier effect. Using the Boston 1991 activitytravel survey data, the study jointly models travel choice set formation and mode choice decision. Automobile dependence is defined and measured as the probability that a traveler has the automobile as the only element in the choice set of travel modes. The study finds a wide variation in levels of automobile dependence along spatial and social dimensions. Elasticity estimates show that automobile dependence is highly sensitive to street network connectivity and to automobile availability, while population/job density and transit supply also matter. The study confirms the choice-enabling role of land use in reducing automobile dependence.
Spectral descriptors for deformable shapes

Informative and discriminative feature descriptors play a fundamental role in deformable shape analysis. For example, they have been successfully employed in correspondence, registration, and retrieval tasks. In the recent years, significant attention has been devoted to descriptors obtained from the spectral decomposition of the Laplace-Beltrami operator associated with the shape. Notable examples in this family are the heat kernel signature (HKS) and the wave kernel signature (WKS). Laplacian-based descriptors achieve state-of-the-art performance in numerous shape analysis tasks; they are computationally efficient, isometry-invariant by construction, and can gracefully cope with a variety of transformations. In this paper, we formulate a generic family of parametric spectral descriptors. We argue that in order to be optimal for a specific task, the descriptor should take into account the statistics of the corpus of shapes to which it is applied (the "signal") and those of the class of transformations to which it is made insensitive (the "noise"). While such statistics are hard to model axiomatically, they can be learned from examples. Following the spirit of the Wiener filter in signal processing, we show a learning scheme for the construction of optimal spectral descriptors and relate it to Mahalanobis metric learning. The superiority of the proposed approach is demonstrated on the SHREC'10 benchmark.
Does Unemployment Cause Future Unemployment? Definitions, Questions and Answers from a Continuous Time Model of Heterogeneity and State Dependence.

Recent research demonstrates that, the greater the number of previous spells of unemployment and the longer their duration, the more likely is the event that an individual will be unemployed at a point in time. Two explanations have been advanced to interpret this finding. The first is rooted in economic theory; the second is based solely on statistical considerations.
Gerontological Social Work: Reflections on its Role, Purpose and Value

Over the last twenty years, successive welfare policies have undermined gerontological social work as a specialist area of social work practice. The UK's ageing population offers an opportunity for gerontological social work to rebuild itself. Increasing numbers of older people with long-term conditions, significant growth in the population of family carers and enhanced community-based living for people with long-term needs combine to reposition social work as—potentially—playing a crucial role in the achievement of key policy goals. The particular skill and knowledge set of social workers uniquely equips them to manage the intersection of issues that currently challenge health and welfare services: complex needs, risk, transitions, end of life, carer stress and frailty. That older service users value the approach, input and expertise of social workers and that social workers have greater capacity to deliver sustainable support are also relevant. For gerontological social work to have a future, not only is it required to reclaim its specialist role, but it must re-establish its commitment to social justice, invest in building an evidence base of effectiveness and embed ageing-related teaching in the social work curriculum.
Implicit Egotism and Major Life Decisions

Because most people possess positive associations about themselves, most people prefer things that are connected to the self (e.g., the letters in one’s name). The authors refer to such preferences as implicit egotism. Ten studies assessed the role of implicit egotism in 2 major life decisions: where people choose to live and what people choose to do for a living. Studies 1–5 showed that people are disproportionately likely to live in places whose names resemble their own first or last names (e.g., people named Louis are disproportionately likely to live in St. Louis). Study 6 extended this finding to birthday number preferences. People were disproportionately likely to live in cities whose names began with their birthday numbers (e.g., Two Harbors, MN). Studies 7–10 suggested that people disproportionately choose careers whose labels resemble their names (e.g., people named Dennis or Denise are overrepresented among dentists). Implicit egotism appears to influence major life decisions. This idea stands in sharp contrast to many models of rational choice and attests to the importance of understanding implicit beliefs. What role do people’s thoughts and feelings about themselves play in their important day-to-day decisions and behaviors? Contemporary research on the self-concept suggests many answers to this question. For example, the desire to maintain positive feelings about the self appears to influence things as diverse as whether people derogate those who criticize their governments (Pyszczynski, Greenberg, & Solomon, 1997, 1999), whether people sabotage the performance of others when playing a game (Tesser & Smith, 1981), what people find rational (Kunda, 1990), and what people find humorous (Wills, 1981). Like people’s social beliefs and behavior, people’s beliefs about themselves are also influenced by the desire to view the self favorably. Most people have
Deep Successor Reinforcement Learning

Learning robust value functions given raw observations and rewards is now possible with model-free and model-based deep reinforcement learning algorithms. There is a third alternative, called Successor Representations (SR), which decomposes the value function into two components -- a reward predictor and a successor map. The successor map represents the expected future state occupancy from any given state and the reward predictor maps states to scalar rewards. The value function of a state can be computed as the inner product between the successor map and the reward weights. In this paper, we present DSR, which generalizes SR within an end-to-end deep reinforcement learning framework. DSR has several appealing properties including: increased sensitivity to distal reward changes due to factorization of reward and world dynamics, and the ability to extract bottleneck states (subgoals) given successor maps trained under a random policy. We show the efficacy of our approach on two diverse environments given raw pixel observations -- simple grid-world domains (MazeBase) and the Doom game engine.
The MCA EXIN neuron for the minor component analysis

The minor component analysis (MCA) deals with the recovery of the eigenvector associated to the smallest eigenvalue of the autocorrelation matrix of the input data and is a very important tool for signal processing and data analysis. It is almost exclusively solved by linear neurons. This paper presents a linear neuron endowed with a novel learning law, called MCA EXINn and analyzes its features. The neural literature about MCA is very poor, in the sense that both a little theoretical basis is given (almost always focusing on the ODE asymptotic approximation) and only experiments on toy problems (at most four-dimensional problems) are presented, without any numerical analysis. This work addresses these problems and lays sound theoretical foundations for the neural MCA theory. In particular, it classifies the MCA neurons according to the Riemannian metric and justifies, from the analysis of the degeneracy of the error cost; the different behavior in approaching convergence. The cost landscape is studied and used as a basis for the analysis of the asymptotic behavior. All the phases of the dynamics of the MCA algorithms are investigated in detail and, together with the numerical analysis, lead to the identification of three possible kinds of divergence, here called sudden, dynamic, and numerical. The importance of the choice of low initial conditions is also explained. A lot of importance is given to the experimental part, where simulations on high-dimensional problems are,presented and analyzed. The orthogonal regression or total least squares (TLS) technique is also presented, together with a real-world application on the identification of the parameters of an electrical machine. It can be concluded that MCA EXIN is the best MCA neuron in terms of stability (no finite time divergence), speed, and accuracy.
Ultra‐deep Illumina sequencing accurately identifies MHC class IIb alleles and provides evidence for copy number variation in the guppy (Poecilia reticulata)

We address the bioinformatic issue of accurately separating amplified genes of the major histocompatibility complex (MHC) from artefacts generated during high‐throughput sequencing workflows. We fit observed ultra‐deep sequencing depths (hundreds to thousands of sequences per amplicon) of allelic variants to expectations from genetic models of copy number variation (CNV). We provide a simple, accurate and repeatable method for genotyping multigene families, evaluating our method via analyses of 209 b of MHC class IIb exon 2 in guppies (Poecilia reticulata). Genotype repeatability for resequenced individuals (N = 49) was high (100%) within the same sequencing run. However, repeatability dropped to 83.7% between independent runs, either because of lower mean amplicon sequencing depth in the initial run or random PCR effects. This highlights the importance of fully independent replicates. Significant improvements in genotyping accuracy were made by greatly reducing type I genotyping error (i.e. accepting an artefact as a true allele), which may occur when using low‐depth allele validation thresholds used by previous methods. Only a small amount (4.9%) of type II error (i.e. rejecting a genuine allele as an artefact) was detected through fully independent sequencing runs. We observed 1–6 alleles per individual, and evidence of sharing of alleles across loci. Variation in the total number of MHC class II loci among individuals, both among and within populations was also observed, and some genotypes appeared to be partially hemizygous; total allelic dosage added up to an odd number of allelic copies. Collectively, observations provide evidence of MHC CNV and its complex basis in natural populations.
Letter detection for homographs with different meanings in different language texts

Tests of inter-lingual homographs that have different meanings across two languages support models postulating initial non-selective access to competing language representations, e.g. Bilingual Interactive Activation (BIA) model. Most such research assessed inter-lingual homographs in the absence of connected text. Here a letter detection paradigm was used that required subjects to detect letters in words in connected text. Prior work with this paradigm suggested that readers respond to only one interpretation of an intra-lingual homograph when detecting letters. Three experiments described here indicate that letter detection patterns to inter-lingual homographs are similar, i.e. detection reflects only a context appropriate interpretation. However, the demonstration that text role, text cohesiveness and bilingual fluency affect inter-lingual letter detection (Experiments 1 and 2), and that word role affects detection even though target frequency is constant across inter-lingual meanings (Experiment 3) indicates that selectivity is in response to post-lexical processes. Thus, results are seen as compatible with tenets of the BIA model.
Epidemiologic Study to Explore Links between Ménière Syndrome and Migraine Headache

Many authors have noted an association between Ménière syndrome and migraine headache. In an attempt to explore a possible link between these two disorders, we performed an epidemiologic study. The National Health Interview Survey (NHIS) includes interviews with tens of thousands of patients annually to estimate the incidence of various diseases. In this study the data collected from the NHIS for the years 1986 to 1988 and 1994 were analyzed to determine the incidence of Ménière syndrome and migraine headache. A total of 423,400 individuals were interviewed over the combined 4 years included in this evaluation. The incidence of migraine headache was calculated at 3.8%, and the incidence of Ménière syndrome was estimated at 0.14%. The incidence of migraine headache inpatients with Ménière syndrome was estimated at 4.5%. The incidence of migraine headache was not substantially elevated in patients with Ménière syndrome when compared to the general population.