Miracle-dz/UniFAR-FTUs huggingface dataset:
Simulation study of the two-dimensional Burridge-Knopoff model of earthquakes

[1] Spatiotemporal correlations of the two-dimensional spring-block (Burridge-Knopoff) model of earthquakes are extensively studied by means of numerical computer simulations. The model is found to exhibit either a “subcritical”, “supercritical” or “near-critical” behavior, depending on the values of the model parameters. Transition between the “subcritical” and “supercritical” regimes is either continuous or discontinuous. Seismic events in the “subcritical” regime and those in the “supercritical” regime at larger magnitudes exhibit universal scaling properties. In the “supercritical” regime, eminent spatiotemporal correlations, e.g., a remarkable growth of seismic activity preceding the main shock, arise in earthquake occurrence, whereas such spatiotemporal correlations are significantly suppressed in the “subcritical” regime. Seismic activity is generically suppressed just before the main shock in a close vicinity of the epicenter of the upcoming event while it remains to be active in the surroundings (the Mogi doughnut). It is also observed that, before and after the main shock, an apparent B-value of the magnitude distribution decreases or increases in the “supercritical” or “subcritical” regimes, respectively. Such distinct precursory phenomena may open a way to the prediction of the upcoming large event.
Metabolism of meso-2,3-dimercaptosuccinic acid in lead-poisoned children and normal adults.

Meso-2,3-dimercaptosuccinic acid (DMSA, or succimer) is an oral chelating agent for heavy-metal poisoning. While studying the urinary elimination of unaltered DMSA, altered DMSA (i.e., its mixed disulfides), and lead in children with lead poisoning, we observed a pattern of urinary drug elimination after meals suggestive of enterohepatic circulation. The excretion of lead in urine patterned the elimination of altered DMSA rather than the parent molecule. In addition, the half-life of elimination of DMSA via the kidney was positively associated with blood lead concentration. Two additional crossover studies of DMSA kinetics were conducted in normal adults to confirm the presence of enterohepatic circulation of DMSA after meals. In one, increases in plasma total DMSA concentration were observed after meals in all six subjects; these increases were prevented by cholestyramine administration 4, 8, and 12 hr after DMSA. In the second, the administration of neomycin also prevented increases in DMSA after meals. These studies indicate that 1) a metabolite(s) of DMSA undergoes enterohepatic circulation and that microflora are required for DMSA reentry; 2) in children, moderate lead exposure impairs renal tubular drug elimination; and 3) a metabolite of DMSA appears to be an active chelator. ImagesFigure 1. AFigure 1. BFigure 2. AFigure 2. BFigure 3. AFigure 3. B
Orthographic Repetition Blindness

Repetition blindness (RB) is the failure to report the second occurrence of a repeated word, when words are sequentially and briefly displayed (Kanwisher, 1987). RB is also observed for non-identical words, such as home, dome. Explanations for non-identity RB assume that similarity at the level of the whole word causes the second word to be suppressed (“similarity inhibition”). Three experiments demonstrate that RB is robust for diverse types of orthographic relatedness, including critical words that share only their first initial letter, their last two letters, first three letters, middle three letters, beginning and final letters, three alternating letters, and three non-aligned letters (as in chance hand). The theoretical construct of similarity inhibition may be able to account for these data, although one mechanism previously proposed in the literature, neighbourhood inhibition, is probably not a useful way to explain the data on RB for words sharing only one or two letters. We introduce an alternative explanation for orthographic RB: Only the repeated letters are suppressed, and amount of RB depends on how easily the perceiver can reconstruct the target word from the non-suppressed letters.
Extravillus endovascular implantation site trophoblast invasion is abnormal in complete versus partial molar pregnancies.

This study examines endovascular trophoblast invasion in pregnancies complicated by complete hydatidiform mole (CM), partial hydatidiform mole (PM) and non-molar abortions (HA). Two hundred consecutive cases from a supra-regional referral centre for suspected trophoblastic disease were examined histologically with particular regard to the presence or absence of endovascular trophoblast invasion of decidual vessels. There were 57 CM, 75 PM and 68 HA. The prevalence of normal endovascular invasion of decidual vessels was significantly lower in CM compared to all other clinical groups, amongst which there were no significant differences. Endovascular trophoblast was identified in about 80 per cent of HA and PM moles, compared to only around 25 per cent of CM (Z = -4.0, P< 0.0001). The majority of cases of complete mole demonstrated a similar appearance, of implantation site showing florid interstitial extravascular trophoblast invasion with surrounding of decidual vessels but without normal endovascular trophoblast invasion or 'plugging' seen. In many cases, there also appeared to be destruction of decidual vessels with interstitial haemorrhage and extensive fresh blood clot present in the histological sections. These findings may provide some explanation regarding the mechanism of clinical findings in molar pregnancy.
Barriers to participating in genetic counseling and BRCA testing during primary treatment for breast cancer

Purpose: Little is known about reasons why eligible breast cancer patients decline BRCA mutation testing. They may withdraw at different stages during genetic counseling for different reasons. We prospectively studied perceived benefits and barriers to genetic counseling and BRCA testing in 102 newly diagnosed breast cancer patients approached for genetic counseling at the start of radiotherapy.Methods: Patients completed questionnaires and participated in interviews at different stages of the counseling protocol.Results: Participation was not influenced by distress, knowledge about hereditary breast cancer, previous genetic testing in relatives, or perceived risks and barriers. Immediate decliners (n = 23) do not believe genetic testing is relevant for them. Patients who decline after pedigree compilation (n = 14) are more hesitant and anxious about the influence of the test result on their future often wishing to postpone further testing. Late decliners (n = 7) withdraw afraid of the test result and/or after a relative's objection. These decliners are not easily identified upon approach because they are similar to patients who receive a DNA test result (n = 58). Notwithstanding their decline, 81% agreed to the timing or would have preferred an earlier approach for genetic counseling.Conclusion: Decliners may make more informed decisions after tailored health education, including adequate risk information.
AN INTRODUCTION TO SOCIAL NETWORK DATA ANALYTICS

The advent of online social networks has been one of the most exciting events in this decade. Many popular online social networks such as Twitter , LinkedIn , and Facebook have become increasingly popular. In addition, a number of multimedia networks such as Flickr have also seen an increasing level of popularity in recent years. Many such social networks are extremely rich in content, and they typically contain a tremendous amount of content and linkage data which can be leveraged for analysis. The linkage data is essentially the graph structure of the social network and the communications between entities; whereas the content data contains the text, images and other multimedia data in the network. The richness of this network provides unprecedented opportunities for data analytics in the context of social networks. This book provides a data-centric view of online social networks; a topic which has been missing from much of the literature. This chapter provides an overview of the key topics in this ﬁ eld, and their coverage in this book.
Service Personnel, Technology, and Their Interaction in Influencing Customer Satisfaction

Managing both the technologies and the personnel needed for providing high-quality, multichannel customer support creates a complex and persistent operational challenge. Adding to this difficulty, it is still unclear how service personnel and these new communication technologies interact to influence the customer’s perceptions of the service being provided. Motivated by both practical importance and inconsistent findings in the academic literature, this exploratory research examines the interaction of media richness, represented by three different technology contexts (telephone, e-mail, and online chat), with six customer service representative (CSR) characteristics and their influences on customer satisfaction. Using a large-sample customer survey data set, the article develops a multigroup structural equation model to analyze these interactions. Results suggest that CSR characteristics influence customer service satisfaction similarly across all three technology-mediated contexts. Of the characteristics studied, service representatives contribute to customer satisfaction more when they exhibit the characteristics of thoroughness, knowledgeableness, and preparedness, regardless of the richness of the medium used. Surprisingly, while three other CSR characteristics studied (courtesy, professionalism, and attentiveness) are traditionally believed to be important in face-to-face encounters, they had no significant impact on customer satisfaction in the technology-mediated contexts studied. Implications for both practitioners and researchers are drawn from the results and future research opportunities are discussed.
In Vitro Antibiotic Susceptibility of Rapidly Growing Nontuberculous Mycobacteria Isolated from Patients with Microbial Keratitis

Purpose: This study was undertaken to determine the antibiotic susceptibility and minimum inhibitory concentrations (MIC) of amikacin, tobramycin, ciprofloxacin, gatifloxacin, azithromycin, and clarithromycin against rapidly growing nontuberculous mycobacteria isolated from patients with keratitis. Methods: A total of 15 rapidly growing nontuberculous mycobacteria isolated from corneal scrapings of keratitis patients from January 1999 through December 2007 were subjected to antimicrobial susceptibility testing by the E-Test to amikacin, tobramycin, ciprofloxacin, gatifloxacin, azithromycin, and clarithromycin. Results: Out of 15 isolates, 13 were identified as Mycobacterium chelonae complex and 2 as Mycobacterium fortuitum complex. Based on minimum inhibitory concentration (MIC) cut off, all 15 (100%) isolates were sensitive to amikacin, azithromycin, and clarithromycin, 13 (86%) were sensitive to tobramycin, nine (60%) to gatifloxacin, and only 6 (40%) to ciprofloxacin. The MIC range was 0.25–4 µg/ml for amikacin, 0.5–1 µg/ml for azithromycin, 0.125–1 µg/ml for clarithromycin, 0.5–16 µg/ml for ciprofloxacin, and 0.25–16 µg/ml for tobramycin. MIC90 for amikacin was 2 µg/ml, azithromycin 1 µg/ml, clarithromycin 0.75 µg/ml, ciprofloxacin 8 µg/ml, gatifloxacin 8 µg/ml, and for tobramycin it was 4 µg/ml. Conclusions: All the isolates were sensitive to amikacin, azithromycin, and clarithromycin, but the MIC values of clarithromycin and azithromycin were lower than amikacin. Based on in vitro susceptibility results it appears that the topical amikacin in combination with oral clarithromycin or azithromycin is the best treatment option for rapidly growing nontuberculous mycobacterial keratitis.
The Effect of Valinomycin on the Electrical Properties of Solutions of Red Cell Lipids in n-Decane

This paper reports the electrical properties of thick lipid membranes in the absence and presence of valinomycin. The thick lipid membranes were formed by placing a solution of sheep red cell lipids in decane between two cellophane partitions which formed the interfaces between the membrane and the two aqueous bathing solutions. The DC electrical resistance of these structures was found to be directly proportional to the reciprocal of the concentration of lipids in the decane (CL). The limiting resistance, as (CL -1) approached zero, was 3 x 108 ohm-cm2. Resistance was also found to be linearly related to membrane thickness. The limiting resistance at zero thickness was again 1–3 x 108 ohm-cm2. These data are interpreted to indicate that the DC resistance of thick lipid membranes comprises two surface resistances (RS) at each interface with the aqueous bathing solutions, and a bulk resistance (RB) of the lipid-decane solution, arranged in series. Measurements of the effect of variations of area on resistance were consistent with this interpretation. Valinomycin reduced RS but had no effect on RB. Under certain conditions, thick lipid membranes containing valinomycin behaved like highly selective K+ electrodes.
Pay Perceptions and Their Relationships with Cooperation, Commitment, and Intent to Quit

This study examines how perceived in-role (or horizontal) pay differences and understanding of the pay system influence three key performance-related attitudes, namely, organizational commitment, willingness to cooperate, and intent to quit, both directly and indirectly via perceived pay fairness. Toward this end, we apply structural equation modeling to self-report survey-based evidence collected from full-time employees in a major United States supermarket licensing group (n = 159). As expected, perception of wide pay differences was negatively related to pay fairness, while pay understanding was positively related to it. Pay fairness played a pivotal mediating role in strengthening organizational commitment and reducing intent to quit. Cooperation was also influenced directly and negatively by pay differences. Contrary to predictions, however, we found that pay fairness did not mediate the relationship between pay differences and cooperation. Implications for compensation theory and practice are considered.
OPTIMIZATION OF CEPHALOSPORIN C PRODUCTION BY CEPHALOSPORIUM ACREMONIUM C-10 USING STATIONARY CULTURE

The present study is concerned with the production of cephalosporin C by Cephalosporium acremonium C-10. Two culture media were tested for the production of antibiotic. Among these culture media M1 containing sucrose, ammonium acetate, cornstarch, sugar cane molasses, soybean meal, calcium carbonate, calcium sulphate and methyl oleate gave optimum production of cephalosporin C. The cultural conditions such as pH 6.5 and temperature 30°C were optimized. The production of antibiotic was found optimal 48 h after conidial inoculation. The effect of size of inoculum was studied and the best results were obtained at 1ml of inoculum size.
Prevalence of QT prolongation and associated LVEF changes in diabetic patients over a four-year retrospective time period

ABSTRACT Aim: To evaluate the prevalence and longitudinal changes of prolonged QTc in DM patients admitted to our community hospital, and to determine, if any, its correlation with changes of left ventricular ejection fraction (LVEF). Methods: A retrospective chart review of patients with Type 1 (T1DM) and Type 2 (T2DM) with at least two admissions during a four-year period was performed to identify QTc interval, and LVEF, as measured on transthoracic echocardiogram. Changes in QTc and LVEF between patient hospital admissions were compared. Results: A prolonged QTc interval was found in 66.7% (n = 24) of type 1 and 51.3% (n = 154) type 2 diabetic patients. The QTc interval is progressively increased in both type 1 and type 2 diabetes during follow-up, although it did not reach statistical significance. A total of 62% patients (23 out 37 patients) had a reduction of LVEF during follow-up. Conclusion and Discussion: High prevalence of QTc prolongation was confirmed in hospitalized patients with in both T1DM and T2DM. Significant reduction of LVEF correlated with QTc prolongation over a mean of 17.3 months in T2DM patients, and may have implications for interventions. Abbreviations CHF: Congestive heart failure LVEF: Left ventricular ejection fraction
TENURE AND PROMOTION DECISIONS: THE RELATIVE IMPORTANCE OF TEACHING, SCHOLARSHIP, AND SERVICE

Research about the relative importance of faculty performance of teaching, scholarship, and service work roles in tenure and promotion decisions is reviewed and updated. Data collected from 130 deans or directors through Internet administration of the Work Role Salience Index (Green & Baskind, 2007) suggested some variation in the weighting of tenure and promotion decisions among different programs and among different types of programs. However, scholarship was salient at a majority of institutions; teaching and service roles have become less influential over time. Conflict between these findings and findings about workload time allocated to scholarship, teaching, and service are identified and implications discussed.
Success on the decks: working-class boys, education and turning the tables on perceptions of failure

Although working-class boys' disengagement with education continues to be a major public concern, the focus of educational research has been on anti-school, hyper-masculine so-called laddish masculinities and their salience within learner identities. What tend to be forgotten are the areas in which low-achieving boys actively engage and succeed in their learning and what these successes mean for their identity construction. This article shows how learning practices manifest themselves in extracurricular peer subcultures by presenting the findings of two related musical activities, DJ-ing and MC-ing. In this music-making, secondary school boys in the Northeast of England showed themselves to be capable of high levels of engagement, enthusiasm and success despite generally being considered low achieving and highly disaffected. This small case study based on semistructured interviews aimed to explore how boys aged 14–16 years enact their passion through creative agency and expressive cultural processes.
Developmental changes in stress adaptation in relation to psychopathology

Abstract As modern neuroscience seeks to understand the neural bases for mental illness, it is becoming increasingly important to define how and when complex neural circuits may be altered in individuals who carry the genetic vulnerability for psychopathology. One factor that could potentially play a contributory role in mental illness is the stress response. A variety of studies suggest that stress can alter the activity of several key cortical neurotransmitters, including glutamate, γ-aminobutyric acid, dopamine, and serotonin. Specifically, exposure to neurotoxic levels of adrenal steroid hormone, particularly if this occurs early in life, could potentially induce permanent changes of these transmitter systems in corticolimbic regions, such as the hippocampal formation and cingulate gyrus, that have a high density of glucocorticoid receptors. Overall, exposure to severe stress during the perinatal period could potentially induce alterations in the circuitry of the anterior cingulate cortex and hippocampal formation and interfere with the normal mechanisms underlying attention and learning.
Labiaplasty, Race and the Colonial Imagination

Abstract This article seeks to interrogate the cultural meaning of cosmetic labiaplasty surgery (CLS) in the Western context through a historical examination of the symbolic function of the labia in relation to the construction of racial difference in early colonial race science discourse. It seeks to think through CLS as materially invested in a transnational masculinist imperial encounter with indigenous women from the Cape of Good Hope, who were identified in the race sciences of the eighteenth to nineteenth centuries as ‘Hottentots’ (and sometimes ‘Bushwomen’). We suggest that the production of desire in contemporary CLS practice and discourse has its roots in colonial anthropological Western representations of black female sexuality. The fear of abnormality so strikingly invoked in the medical literature and contemporary accounts of women's desire for CLS appears as a displacement of racial abjection onto the genitals and a production of the female body as the border object upon which the desire for whiteness is transcribed. We identify two interlocking features of this production of white desire: the rejection of the animal body and the correction of sexual deviancy, both of which are articulated through race, specifically the racialised ‘Hottentot’ bodies conjured up by the white, colonial imagination.
Demographic, breast-feeding, and nutritional trends among children with type 1 diabetes mellitus

Background: The pathogenesis of type 1 diabetes mellitus (T1DM) requires a genetic predisposition to particular environmental triggers that may activate mechanisms leading to progressive loss of pancreatic beta cells. Aims: We tried to compare the impact of some demographic and environmental factors and breast-feeding on children (aged < 18 years) with recent onset diabetes mellitus (≤1 year) with that on age, sex, and socioeconomic status-matched controls. Material and Methods: A total of 43 consecutive patients (male, 24, mean age ± SD = 12.58 ± 9.6 years) and equal number of controls without diabetes mellitus or dysglycemia were included in this hospital-based case-control study. Results and Conclusions: A distinct peak in the incidence noted in the early adolescence with segregation in the winter months. Our patients did not differ significantly from the controls with regard to birth order, mode of delivery, parental age, parental education, dietary practices, breast-feeding, and migration in the family. Growth characteristics and nutritional status were also similar. A population study with more power will be better equipped to answer such queries.
Design, control, and testing of a thumb exoskeleton with series elastic actuation

We present an exoskeleton capable of assisting the human thumb through a large range of motion. Our novel thumb exoskeleton has the following unique features: (i) an underlying kinematic mechanism that is optimized to achieve a large range of motion, (ii) a design that actuates four degrees of freedom of the thumb, and (iii) a series elastic actuation based on a Bowden cable, allowing for bidirectional torque control of each thumb joint individually. We present a kinematic model of the coupled thumb exoskeleton system and use it to maximize the range of motion of the thumb. Finally, we carry out tests with the designed device on four subjects to evaluate its workspace and kinematic transparency using a motion capture system and torque control performance. Results show that the device allows for a large workspace with the thumb, is kinematically transparent to natural thumb motion to a high degree, and is capable of accurate torque control.