Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of SO on 1,1,1‐Trichloroethane Degradation by Fe0 in Aqueous Solution

Sulfate in groundwater has been previously shown to change the reactivity of Fe0 in permeable reactive barriers for reducing chlorinated organics. To better understand the effect and mechanism of SO, the degradation of 1,1,1‐trichloroethane (TCA) by Fe0 in unbuffered aqueous solutions with and without SO was investigated. In a Fe0‐TCA‐H2O system with initial pH of 2.0 to 10.0, the maximum removal rate of TCA was achieved at the initial pH 6.0 with pseudo‐first‐order constant Kobs 9.0 × 10−3/min. But in a Fe0‐TCA‐Na2SO4‐H2O system, the removal rate of TCA decreased remarkably with a reduction in Kobs to 1.0 × 10−3/min, and the pH varied from 6.0 to 9.6, indicating an inhibition of TCA dehydrochlorination by SO. Sulfate remarkably inhibited TCA degradation via changing the route of Fe0 dissolution. It accelerated the dissolution of Fe0 and transformed the intermediate form Fe(OH)ads to Fe2(SO4)ads, which weakened the affinity between Fe and TCA, and thus depressed the degradation of TCA by Fe0.
Effect of brief training on reliability and applicability of Global Assessment of functioning scale by Psychiatric clinical officers in Uganda.

BACKGROUND The Global Assessment of Functioning (GAF) is the standard method and an essential tool for representing a clinician's judgment of a patient's overall level of psychological, social and occupational functioning. As such, it is probably the single most widely used method for assessing impairment among the patients with psychiatric illnesses. OBJECTIVE To assess the effects of one-hour training on application of the GAF by Psychiatric Clinical Officers' in a Ugandan setting. METHOD Five Psychiatrists and five Psychiatric Clinical Officers (PCOs) or Assistant Medical Officers who hold a 2 year diploma in Clinical Psychiatry were randomly selected to independently rate a video-recorded psychiatric interview according to the DSM IV-TR. The PCOs were then offered a one-hour training on how to rate the GAF scale and asked to rate the video case interview again. All ratings were assigned on the basis of past one year, at admission and current functioning. Interclass correlations (ICC) were computed using two-way mixed models. RESULTS The ICC between the psychiatrists and the PCOs before training in the past one year, at admission and current functioning were +0.48, +0.51 and +0.59 respectively. After training, the ICC coefficients were +0.60, +0.82 and +0.83. CONCLUSION Brief training given to PCOs improved the applications of their ratings of GAF scale to acceptable levels. There is need for formal training to this cadre of psychiatric practitioners in the use of the GAF.
Treatment for depression following mild traumatic brain injury in adults: A meta-analysis

Abstract Primary objective: Development of depression after TBI is linked to poorer outcomes. The aim of this manuscript is to review evidence for the effectiveness of current treatments. Research design: Two meta-analyses were undertaken to examine the effectiveness of both pharmacological and non-pharmacological interventions for depression after mild TBI Method and procedures: PubMed, Medline, PsychInfo, Web of Science and Digital Dissertations were searched and 13 studies located. Meta Analyst Beta 3.13 was used to conduct analyses of pre- vs post-effects then to examine treatment group vs control group effects. Main outcomes and results: Studies using a pre–post design produced an overall effect size of 1.89 (95% CI = 1.20–2.58, p < 0.001), suggesting that treatments were effective; however, the overall effect for controlled trials was 0.46 (95% CI = −0.44–1.36, p < 0.001), which favoured the control rather than treatment groups. Conclusions: This study highlights the need for additional large well-controlled trials of effective treatments for depression post-TBI.
Pixilated partnerships, overcoming obstacles in qualitative interviews via Skype: a research note

This research note discusses the effectiveness of using video internet technologies, like Skype, for qualitative interviews. Skype may present some challenges for interviewing, including dropped calls and pauses, inaudible segments, inability to read body language and nonverbal cues, and loss of intimacy compared to traditional in-person interviews. Based on reflections from 45 university student researchers, the following short paper details how to overcome such obstacles and to create a successful research partnership between the researcher and participant. Strategies include confirming a stable internet connection, finding a quiet room without distractions, slowing down and clarifying talk, being open to repeating answers and questions, and paying close attention to facial expressions.
Dyspnoea perception during clinical remission of atopic asthma

Symptoms of atopic asthma often disappear around puberty. The authors recently demonstrated that this clinical remission is accompanied with ongoing airways inflammation in most subjects. The discrepancy between lack of symptoms and persistent airway inflammation suggests that perception of the symptoms is unclear. In the present study, young adults in clinical remission of atopic asthma assigned themselves a modified Borg score during methacholine and adenosine-5′-monophosphate induced bronchoconstriction. Borg scores of subjects in clinical remission were compared with those of symptomatic asthmatic subjects. A marked variation in the Borg scores at a 20% fall in the forced expiratory volume in one second was found. Significant differences in Borg scores between remission patients and asthmatics could not be detected. It was concluded that perception of dyspnoea, induced with methacholine and adenosine challenge, is similar in young adults in clinical remission of atopic asthma compared to that of patients with symptomatic asthma. Hence, an unclear perception seems to be an unlikely explanation for the discrepancy between lack of symptoms and ongoing inflammation. Other factors, including both physical and psychological ones, may play a role in the apparent absence of symptoms, thereby potentially leading to undertreatment.
The Economic (in)Efficiency of Devolution

The recent devolutionary trend across the world has been in part fuelled by claims of a supposed ‘economic dividend’ associated with the decentralization of authority and resources. The capacity of devolved administrations with greater autonomous powers to tailor policies to local preferences, to generate innovation in the provision of policies and public services, and to encourage greater participation and be more accountable is supposed to deliver greater economic efficiency. There is, however, little empirical evidence to substantiate these claims. In this paper we assess the horizontal link between devolution and regional economic growth in six national contexts (Germany, India, Italy, Mexico, Spain, and the USA). Regression analyses are used in order to test whether changes in cross-regional differences in growth patterns within each country can be attributed to changes in levels of regional autonomy. The results suggest that, contrary to the expectations of devolutionists, the degree of devolution is in most cases irrelevant for economic growth and, when it matters—as in the cases of Mexico and the USA—it is linked to lower rather than greater economic efficiency.
Evaluating speech features with the minimal-pair ABX task (II): resistance to noise

The Minimal-Pair ABX (MP-ABX) paradigm has been proposed as a method for evaluating speech features for zeroresource/unsupervised speech technologies. We apply it in a phoneme discrimination task on the Articulation Index corpus to evaluate the resistance to noise of various speech features. In Experiment 1, we evaluate the robustness to additive noise at different signal-to-noise ratios, using car and babble noise from the Aurora-4 database and white noise. In Experiment 2, we examine the robustness to different kinds of convolutional noise. In both experiments we consider two classes of techniques to induce noise resistance: smoothing of the time-frequency representation and short-term adaptation in the time-domain. We consider smoothing along the spectral axis (as in PLP) and along the time axis (as in FDLP). For short-term adaptation in the time-domain, we compare the use of a static compressive non-linearity followed by RASTA filtering to an adaptive compression scheme.
Treatment integrity of interventions with children in School Psychology International from 1995–2010

Over the past two decades, the role of school psychologists internationally has shifted from a more narrow focus on assessment to a broader emphasis on problem solving and delivering intervention services via consultation. Defining interventions is important for replication and translation of practice. Further, to make valid, data-based decisions about intervention effectiveness, school psychologists need to consider student outcomes in light of treatment integrity data. Reviews of treatment outcome research in many applied fields indicate that although many researchers operationally define interventions, a majority of researchers fail to report treatment integrity data. The purpose of this study was to review the treatment integrity data reported in intervention studies published in School Psychology International between 1995–2010. Results indicate a majority of published studies include neither a definition of the independent variable nor quantitative treatment integrity data. Implications for research and practice are discussed.
“To thine own self(ves) be true”: Reflexive insights for etic self theory from consumers’ emic constructions of the self

The self and related multiple self constructs while widely applied in many guises in consumption‐focused research may be surprisingly underdetermined or misconstrued. What has been missing in particular is a critical perspective assessing an emic view of consumers’ personal theories and narratives of the self. A study using written protocols was conducted to investigate these consumer perspectives and a hermeneutic thematic analysis was developed. Varying accounts of the self in terms of its definition, multiplicity, and related dialectical and reflexive consumption processes were found, suggesting that prior etic self theories ignored many nuances of consumers’ constructions of the self. Building on these accounts, an enhanced theoretical framework of the self emerges involving multiple personal constructions of the self, the reflexivity of the narrative of the self (theory of the self as a construct) with the narrative of oneself (identity construction) and a critical perspective on the discourses of self reflexively involving etic–researcher and emic–consumer cultures.
Combining model-based and combinatorial testing for effective test case generation

Model-based testing relies on the assumption that effective adequacy criteria can be defined in terms of model coverage achieved by a set of test paths. However, such test paths are only abstract test cases and input test data must be specified to make them concrete. We propose a novel approach that combines model-based and combinatorial testing in order to generate executable and effective test cases from a model. Our approach starts from a finite state model and applies model-based testing to generate test paths that represent sequences of events to be executed against the system under test. Such paths are transformed to classification trees, enriched with domain input specifications such as data types and partitions. Finally, executable test cases are generated from those trees using t-way combinatorial criteria. While test cases that satisfy a combinatorial criterion can be generated for each individual test path obtained from the model, we introduce a post-optimization algorithm that can guarantee the combinatorial criterion of choice on the whole set of test paths extracted from the model. The resulting test suite is smaller, but it still satisfies the same adequacy criterion. We developed a tool and used it to evaluate our approach on 6 subject systems of various types and sizes, to study the effectiveness of the generated test suites, the reduction achieved by the post-optimization algorithm, as well as the effort required to produce them.
TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

T helper type 17 (Th17) cells play an important pathogenic function in autoimmune diseases; their regulation, however, is not well understood. We show that the expression of a tumor necrosis factor receptor family member, death receptor 3 (DR3; also known as TNFRSF25), is selectively elevated in Th17 cells, and that TL1A, its cognate ligand, can promote the proliferation of effector Th17 cells. To further investigate the role of the TL1A–DR3 pathway in Th17 regulation, we generated a TL1A-deficient mouse and found that TL1A−/− dendritic cells exhibited a reduced capacity in supporting Th17 differentiation and proliferation. Consistent with these data, TL1A−/− animals displayed decreased clinical severity in experimental autoimmune encephalomyelitis (EAE). Finally, we demonstrated that during EAE disease progression, TL1A was required for the optimal differentiation as well as effector function of Th17 cells. These observations thus establish an important role of the TL1A–DR3 pathway in promoting Th17 cell function and Th17-mediated autoimmune disease.
Characteristic subsurfaces, character varieties and Dehn fillings

Let M be a one-cusped hyperbolic 3‐manifold. A slope on the boundary of the compact core of M is called exceptional if the corresponding Dehn filling produces a non-hyperbolic manifold. We give new upper bounds for the distance between two exceptional slopes and in several situations. These include cases where M. / is reducible and where M. / has finite 1 , or M. / is very small, or M. / admits a 1 ‐injective immersed torus. 57M25, 57M50, 57M99
Freshman Year Dropouts: Interactions Between Student and School Characteristics and Student Dropout Status

Data from a large school district in the southwestern United States were analyzed to investigate relations between student and school characteristics and high school freshman dropout patterns. Application of a multilevel logistic regression model to student dropout data revealed evidence of school-to-school differences in student dropout rates and school-to-school differences in the relation between student characteristics and student dropout status. Investigation of the school differences revealed that school organization and schools' social context were statistically significant predictors of several of the dropout outcomes. Evidence of school context and school practice effects on student dropout outcomes suggests that school personnel may need to consider how characteristics of the school environment interact with the background characteristics of students when developing and focusing dropout prevention strategies. Implications for school policy and practice are discussed.
Museums and the Visually Impaired: The Spatial Politics of Access

Based on a study of 36 museums in London and the South East of England, the paper offers a deconstructive reading of ‘access’ and its spatial practices by analysing their responses to the visually impaired visitor. Within any discursive space we find aporial, non-discursive moments that introduce ambivalence into an otherwise seemingly ordered and known arrangement. Such forms of presence have been described, amongst other things, under the heading of the figural (Lyotard). In the discursive space of the museum, a space of seeing and conservation, the visually impaired visitor figure tacks its way into the museum as such a figure that we can call (after Mark C. Taylor) an underdetermined not. Through such a figure we can consider the (dis)ordering effects that this ambivalent form of presence can have. The study reveals how such a figure not only introduces a problem of access but is also mobilised by the museum so that access can be addressed as a museum issue. Museums have changed from previously being indifferent to dis/ability needs to now existing in a state of being in-difference with them. This idea reveals the way in which museums shift the (often haptic) challenge that such a figure makes to the (scopic) signifiers of the museum by responding to them through the less troublesome regimes of what is signified. Access in this case is neither granted nor denied but endlessly deferred.
Isolating the Symbolic Implications of Employee Mobility: Price Increases after Hiring Winemakers from Prominent Wineries

Because wines are aged for several years before they are released, newly hired winemakers arrive as wines made by their predecessors enter the market. An analysis of winemaker hiring events reveals that wines released right after a new winemaker's arrival from a prominent competitor are priced significantly higher than corresponding wines released in the preceding year. However, the wines released before and after the hiring event are indistinguishable in terms of quality. These findings isolate a "purely symbolic" effect of employee mobility, which affirm sociological accounts of markets--under conditions of uncertainty, inter-organizational affiliations condition producers' returns to quality demonstrations.
Phosphorylation-Dependent Targeting of Tetrahymena HP1 to Condensed Chromatin

Compacting the genome to various degrees influences processes that use DNA as a template, such as gene transcription and replication. This project was aimed at learning more about the cellular mechanisms that control genome compaction. Posttranslational modifications of proteins involved in genome condensation are emerging as potentially important points of regulation. To help elucidate protein modifications and how they affect the function of condensation proteins, we investigated the phosphorylation of the chromatin protein called Hhp1 in the ciliated protozoan Tetrahymena thermophila. This is one of the first functional investigations of these modifications of a nonhistone chromatin condensation protein that acts on the ciliate genome, and discoveries will aid in identifying common, evolutionarily conserved strategies that control the dynamic compaction of genomes. ABSTRACT The evolutionarily conserved proteins related to heterochromatin protein 1 (HP1), originally described in Drosophila, are well known for their roles in heterochromatin assembly and gene silencing. Targeting of HP1 proteins to specific chromatin locales is mediated, at least in part, by the HP1 chromodomain, which binds to histone H3 methylated at lysine 9 that marks condensed regions of the genome. Mechanisms that regulate HP1 targeting are emerging from studies with yeast and metazoans and point to roles for posttranslational modifications. Here, we report that modifications of an HP1 homolog (Hhp1) in the ciliate model Tetrahymena thermophila correlated with the physiological state and with nuclear differentiation events involving the restructuring of chromatin. Results support the model in which Hhp1 chromodomain binds lysine 27-methylated histone H3, and we show that colocalization with this histone mark depends on phosphorylation at a single Cdc2/Cdk1 kinase site in the “hinge region” adjacent to the chromodomain. These findings help elucidate important functional roles of reversible posttranslational modifications of proteins in the HP1 family, in this case, regulating the targeting of a ciliate HP1 to chromatin regions marked with methylated H3 lysine 27. IMPORTANCE Compacting the genome to various degrees influences processes that use DNA as a template, such as gene transcription and replication. This project was aimed at learning more about the cellular mechanisms that control genome compaction. Posttranslational modifications of proteins involved in genome condensation are emerging as potentially important points of regulation. To help elucidate protein modifications and how they affect the function of condensation proteins, we investigated the phosphorylation of the chromatin protein called Hhp1 in the ciliated protozoan Tetrahymena thermophila. This is one of the first functional investigations of these modifications of a nonhistone chromatin condensation protein that acts on the ciliate genome, and discoveries will aid in identifying common, evolutionarily conserved strategies that control the dynamic compaction of genomes.
Rapid diagnosis of maple syrup urine disease in blood spots from newborns by tandem mass spectrometry.

We report a new method for the diagnosis of maple syrup urine disease (MSUD) from dried blood spots on newborn screening cards based on tandem mass spectrometry (MS-MS). The mean +/- SD concentration of Leu plus Ile in normal newborns was 151 +/- 47 mumol/L (n = 1096); for Val, 131 +/- 58 mumol/L (n = 791). SDs were lower when the concentrations of these amino acids were expressed relative to that of Phe. The mean ratio for Leu + Ile to Phe was 2.5 +/- 0.49; for Val to Phe, 2.18 +/- 0.51. These results compare well with values previously reported in the literature. With these criteria, samples from a collection categorized by a bacterial inhibition assay as normal or falsely positive for MSUD were normal by MS-MS [(Leu + Ile): Phe < 5.0]. Samples from confirmed MSUD patients were categorized as abnormal [(Leu+Ile): Phe > 9.0] by MS-MS.
Plasma concentrations of endotoxin and antiendotoxin antibodies in patients with multiple injuries: a prospective clinical study.

OBJECTIVE To investigate the time course of endotoxaemia and its effects on the synthesis of antiendotoxin antibodies in patients with multiple injuries. DESIGN Prospective clinical study. SETTING University hospital, Germany. PATIENTS 40 Patients with multiple injuries and 20 healthy volunteers who served as controls. INTERVENTIONS Blood samples were collected up to 10 days after injury and the concentrations of endotoxin, antiendotoxin antibodies to four endotoxins, and for anti-alpha-haemolysin of Staphylococcus aureus were measured. The kinetics of endotoxaemia and antiendotoxin antibodies were investigated. RESULTS Endotoxaemia peaked 0-3 hours after injury at 0.425 EU/ml and decreased thereafter to 0.04 EU/ml within five days. Total concentrations of IgM, IgA, and IgG increased continuously after day 3 (p < 0.05), but the specific IgM response to all endotoxins was only temporary and the relative content of specific antibodies to all endotoxins peaked at day 3 (p < 0.05). Antiendotoxin antibodies of IgM class cross-reacted among themselves. There was no general increase in specific antiendotoxin antibodies of IgA and IgG class. The relative content of specific antibodies to alpha-haemolysin of S aureus of all classes of immunoglobulins (IgM, IgA, IgG) remained on the same level from day 0-10. CONCLUSION Multiple injuries are associated with early and temporary endotoxaemia which causes specific increases in antiendotoxin antibodies of the IgM-class. IgM antibodies to endotoxins cross-react among themselves.
Three Multiplex Assays for Detection of Borrelia burgdorferi sensu lato and Borrelia miyamotoi sensu lato in Field-Collected Ixodes Nymphs in North America

Abstract Two hundred fifty New Jersey field-collected Ixodes scapularis Say ticks and 17 Colorado Ixodes spinipalpis Hadwen & Nuttall ticks were tested using three separate multiplex real-time polymerase chain reaction (PCR) assays. One assay targets the rrs-rrlA IGS region of Borrelia spp. to detect Borrelia burgdorferi sensu lato (s.l.) and Borrelia miyamotoi s.l. The second assay targets the ospA region of B. burgdorferi s.l. to detect B. burgdorferi sensu stricto (s.s.), Borrelia bissettii, and Borrelia andersonii. The final assay targets the glpQ region of B. miyamotoi s.l. to differentiate B. miyamotoi LB-2001 and Borrelia lonestari. A testing scheme combining these tests yielded 18% of tested I. scapularis ticks surveyed from New Jersey positive for B. burgdorferi s.s. , 3.2% I. scapularis ticks positive for B. miyamotoi LB-2001, and 41.2% I. spinipalpis ticks positive for B. bissettii surveyed from Colorado.