Miracle-dz/UniFAR-FTUs huggingface dataset:
EFFECTS OF ELASTIC BANDS ON FORCE AND POWER CHARACTERISTICS DURING THE BACK SQUAT EXERCISE

Athletes commonly use elastic bands as a training method to increase strength and performance. The purpose of this study was to investigate the effect of elastic bands on peak force (PF), peak power (PP), and peak rate of force development (RFD) during the back-squat exercise (BSE). Ten recreationally resistance-trained subjects (4 women, 6 men, mean age 21.3 ± 1.5 years) were tested for their 1 repetition maximum (1RM) in the BSE (mean 117.6 ± 48.2 kg) on a Smith machine. Testing was performed on 2 separate days, with 2 sets of 3 repetitions being performed for each condition. Testing was conducted at 60% and 85% of 1RM with and without using elastic bands. In addition, 2 elastic band loading conditions were tested (B1 and B2) at each of the 2 resistances. No bands (NB) represents where all of the resistance was acquired from free-weights. B1 represents where approximately 80% of the resistance was provided by free-weights, and approximately 20% was provided by bands. B2 represents where approximately 65% of the resistance was provided by free-weights, and approximately 35% was provided from bands. The subjects completed the BSE under each condition, whereas PF, PP, and RFD was recorded using a force platform. There was a significant (p < 0.05) increase in PF between NB-85 and B2-85 of 16%. Between B1-85 and B2-85, PF was increased significantly by 5% (p < 0.05). There was a significant (p < 0.05) increase in PP between NB-85 and B2-85 of 24%. No significant differences were observed in RFD during the 85% conditions or for any of the measured variables during the 60% conditions (p < 0.05). The results suggest that the use of elastic bands in conjunction with free weights can significantly increase PF and PP during the BSE over free-weight resistance alone under certain loading conditions. The greatest differences are observed during the higher loading conditions, with the B1-85 condition appearing to be optimal for athletic performance of the ones we tested. The strength training professional could use variable resistance training (VRT) to increase PF and PP more than the traditional BSE can. VRT could also be used to train these 2 performance characteristics together, which might be especially useful in season, when weight-room training volume can sometimes be limited.
Distributed cerebellar plasticity implements generalized multiple-scale memory components in real-robot sensorimotor tasks

The cerebellum plays a crucial role in motor learning and it acts as a predictive controller. Modeling it and embedding it into sensorimotor tasks allows us to create functional links between plasticity mechanisms, neural circuits and behavioral learning. Moreover, if applied to real-time control of a neurorobot, the cerebellar model has to deal with a real noisy and changing environment, thus showing its robustness and effectiveness in learning. A biologically inspired cerebellar model with distributed plasticity, both at cortical and nuclear sites, has been used. Two cerebellum-mediated paradigms have been designed: an associative Pavlovian task and a vestibulo-ocular reflex, with multiple sessions of acquisition and extinction and with different stimuli and perturbation patterns. The cerebellar controller succeeded to generate conditioned responses and finely tuned eye movement compensation, thus reproducing human-like behaviors. Through a productive plasticity transfer from cortical to nuclear sites, the distributed cerebellar controller showed in both tasks the capability to optimize learning on multiple time-scales, to store motor memory and to effectively adapt to dynamic ranges of stimuli.
A Comparison of Methods for Identifying the Translation of Words in a Comparable Corpus: Recipes and Limits

Identifying translations in comparable corpora is a challenge that has attracted many researchers since a long time. It has applications in several applications including Machine Translation and Cross-lingual Information Retrieval. In this study we compare three state-of-the-art approaches for these tasks: the so-called context-based projection method, the projection of monolingual word embeddings, as well as a method dedicated to identify translations of rare words. We carefully explore the hyper-parameters of each method and measure their impact on the task of identifying the translation of English words in Wikipedia into French. Contrary to the standard practice, we designed a test case where we do not resort to heuristics in order to pre-select the target vocabulary among which to find translations, therefore pushing each method to its limit. We show that all the approaches we tested have a clear bias toward frequent words. In fact, the best approach we tested could identify the translation of a third of a set of frequent test words, while it could only translate around 10% of rare words.
Pragmatics-based translation and MT evaluation

In this paper the authors wish to present a view of translation equivalence related to a pragmatics-based approach to machine translation. We will argue that current evaluation methods which assume that there is a predictable correspondence between language forms cannot adequately account for this view. We will then describe a method for objectively determining the relative equivalence of two texts. However, given the need for both an open world assumption and non-monotonic inferencing, such a method cannot be realistically implemented and therefore certain "classic" evaluation strategies will continue to be preferable as practical methods of evaluation.
Locoregional spread of cutaneous melanoma: sonography findings.

OBJECTIVE This article reviews various aspects of locoregional spread of malignant cutaneous melanoma, as imaged with gray-scale sonography and Doppler techniques. The scenarios illustrated include disease staging (primary melanoma, satellite metastasis, in-transit metastasis, and lymphadenopathies), sentinel lymph node biopsy procedure, patient follow-up, recurrence detection, cutaneous metastasis, and sonographically guided intervention. CONCLUSION High-resolution sonography allows recognition of small, clinically-occult melanomatous foci. It plays a major role in locoregional staging and follow-up of patients with cutaneous melanoma.
Vasoactive Intestinal Peptide Enhances Its Own Expression in Sympathetic Neurons after Injury

Neurons in the adult rat superior cervical sympathetic ganglion (SCG) dramatically increase their content of vasoactive intestinal peptide (VIP) and its mRNA after axotomy in vivo and after explantation. Because the VIP gene contains a functional cAMP response element, the effects of cAMP-elevating agents on VIP expression were examined. VIP, forskolin, or isoproterenol increased cAMP accumulation in explanted ganglia. Secretin, a peptide chemically related to VIP, or forskolin increased VIP levels above those seen in ganglia cultured in control medium, whereas treatment with VIP or secretin increased the level of peptide histidine isoleucine (PHI), a peptide coded for by the same mRNA that encodes VIP. VIP or forskolin also increased VIP–PHI mRNA. In contrast, isoproterenol did not alter levels of VIP, PHI, or VIP–PHI mRNA. Although VIP or forskolin increased cAMP levels in both dissociated neurons and in non-neuronal cells, isoproterenol significantly stimulated cAMP accumulation only in the latter. VIP6–28 was an effective antagonist of the actions of exogenous VIP on cAMP and VIP–PHI mRNA in neuron-enriched cultures. When adult SCG explants were cultured in defined medium, endogenous VIP immunoreactivity was released. When VIP6–28was added to such cultures, it significantly inhibited the increase in VIP–PHI mRNA that normally occurs. These data indicate that VIP, or a closely related molecule, produced by adult neurons after injury can enhance the expression of VIP. Such a mechanism may prolong the period during which VIP is elevated after axonal damage. The possibility is also discussed that, because VIP is present in preganglionic neurons in normal animals, its release during periods of increased sympathetic nerve activity could alter VIP expression in the SCG.
Migraine and retinal microvascular abnormalities

Objective: This study examined the association between vascular headaches and retinal microvascular disease. Methods: We investigated the cross-sectional association between headaches (migraine/other headaches with aura, migraine without aura, other headaches without aura, no headaches) and retinal microvascular signs (retinopathy, focal arteriolar narrowing, arteriovenous nicking; arteriolar and venular calibers) among middle-aged African American and white men and women from the third examination of the Atherosclerosis Risk in Communities Study (1993 through 1995). Results: After controlling for age, gender, race, study center, and cardiovascular risk factors, we determined that persons with headaches were more likely to have retinopathy than those without a history of headaches (odds ratio [OR] = 1.38, 95% CI = 0.96 to 1.99 for migraine/other headaches with aura; OR = 1.49, 95% CI = 1.05 to 2.12 for migraine without aura; and OR = 1.28, 95% CI = 0.99 to 1.65 for other headaches). Associations with migraine were stronger among the subset of participants without a history of diabetes or hypertension (OR = 1.79, 95% CI = 1.09 to 2.95 for migraine/other headaches with aura; and OR = 1.74, 95% CI = 1.11 to 2.71 for migraine without aura). Headaches were not associated with focal arteriolar narrowing or arteriovenous nicking. Persons with headaches tended to have smaller mean arteriolar and venular calibers; however, these associations did not tend to persist among those without hypertension or diabetes. Conclusion: Middle-aged persons with migraine and other headaches were more likely to have retinopathy signs, supporting the hypothesis that neurovascular dysfunction may underlie vascular headaches.
A clinical predictor of varices and portal hypertensive gastropathy in patients with chronic liver disease

Background/Aims The aim of this study was to identify the parameters that could noninvasively predict the presence of esophageal/gastric varices and portal hypertensive gastropathy (PHG) in patients with chronic liver disease (CLD), and to determine the accuracy of those parameters. Methods We retrospectively analyzed 232 patients with CLD who underwent both upper endoscopy and liver CT within an interval of 3 months. The multidimensional index (M-Index) for spleen volume was obtained from the multiplication of splenic length, width, and thickness, as measured by computer tomography. Results The multivariate analysis revealed that platelet, albumin, and M-Index were independently associated with the presence of varices and PHG. We combined three independent parameters, and developed a varices and portal hypertensive gastropathy (VAP) scoring system (=[platelet count (/mm3)×albumin (g/dL)]/[M-Index (cm3)]). The area under the receiver operating characteristic curve of the VAP score was 0.850 (95% confidence interval, 0.801-0.899). The VAP cut-off value of 861 had a sensitivity of 85.3%, a positive likelihood ratio of 3.17, and a negative predictive value of 86.4%. For predicting high-risk lesions for bleeding, with a cut-off value of 861 the sensitivity was 92.0%, the positive likelihood ratio was 2.20, and the negative predictive value was 96.4%. Conclusions The VAP score can predict the presence of varices and PHG in patients with CLD and may increase the cost-benefit of screening endoscopy in the clinical practice setting. A prospective validation study is necessary in the future.
Flow under Curvature: Singularity Formation, Minimal Surfaces, and Geodesics

We study hypersurfacesmoving under flow that depends on the mean curvature. The approach is based on a numerical technique that embeds the evolving hypersurface as the zero level set of a family of evolving surfaces. In this setting, the resulting partial differential equation for the motion of the level set function may be solved by using numerical techniques borrowed from hyperbolic conservation laws. This technique is applied to several problems: the evolution of a dumbbell, and related many-armed surfaces, collapsing under mean curvature; the construction of a minimal surface attached to a given one-dimensional wire frame in R3, and, more generally, the construction of surfaces whose mean curvature is a prescribed function of position; the motion of curves on two-manifolds under flow that depends on geodesic curvature. Some experiments involving flow controlled by Gaussian curvature are also included.
Analysis and Improvement of Fairness among TCP Connections transmitting Differently Sized Data

Short-lived TCP connections, which transmit small-sized data, suffer from significant low throughput compared with long-lived TCP connections, which transmit large-sized data, because of the inherent nature of the ACK-based window flow control of TCP. In this paper, we focus on the unfairness problem caused by transmitting differently sized data. We first confirm the unfairness property through simple simulation results, and show the necessity of devising a method to improve the fairness property at the router buffer. As preparation for realizing this method, we next introduce a new analysis approach to estimate the throughput of a TCP connection when the packet loss probabilities of each transmitted packet are different. Our analysis gives a better estimation of the TCP throughput than the existing analyses. Using the analysis results, we propose a new method to improve the fairness property, and show that our proposed method can improve the fairness property without degradation of the network link utilization.
The PHA Test Reflects Acquired T-Cell Mediated Immunocompetence in Birds

Background cological immunology requires techniques to reliably measure immunocompetence in wild vertebrates. The PHA-skin test, involving subcutaneous injection of a mitogen (phytohemagglutinin, PHA) and measurement of subsequent swelling as a surrogate of T-cell mediated immunocompetence, has been the test of choice due to its practicality and ease of use in the field. However, mechanisms involved in local immunological and inflammatory processes provoked by PHA are poorly known, and its use and interpretation as an acquired immune response is currently debated. Methodology Here, we present experimental work using a variety of parrot species, to ascertain whether PHA exposure produces larger secondary than primary responses as expected if the test reflects acquired immunocompetence. Moreover, we simultaneously quantified T-lymphocyte subsets (CD4+, CD5+ and CD8+) and plasma proteins circulating in the bloodstream, potentially involved in the immunological and inflammatory processes, through flow cytometry and electrophoresis. Principal Findings Our results showed stronger responses after a second PHA injection, independent of species, time elapsed and changes in body mass of birds between first and second injections, thus supporting the adaptive nature of this immune response. Furthermore, the concomitant changes in the plasma concentrations of T-lymphocyte subsets and globulins indicate a causal link between the activation of the T-cell mediated immune system and local tissue swelling. Conclusions/Significance These findings justify the widespread use of the PHA-skin test as a reliable evaluator of acquired T-cell mediated immunocompetence in diverse biological disciplines. Further experimental research should be aimed at evaluating the relative role of innate immunocompetence in wild conditions, where the access to dietary proteins varies more than in captivity, and to ascertain how PHA responses relate to particular host-parasite interactions.
Field-Based Inquiry as a Signature Pedagogy for Geography in Singapore

Abstract For school geography in Singapore, geographical inquiry is identified as a “signature pedagogy” (Shulman 2005a) that can socialize students into the distinctive practices, concepts, and values of the discipline of geography. This article explores how field-based inquiry is applied across four secondary schools in Singapore to develop an understanding of teachers’ knowledge and practices of disciplined inquiry. We outline the practical challenges and opportunities involved in adopting inquiry as a signature pedagogy for school geography. The results suggest a need to develop teachers’ place-based knowledge and relevant scientific content knowledge to support the design of field-based learning experiences for students.
Energy performance of demand controlled mechanical extract ventilation systems vs mechanical ventilation systems with heat recovery in operational conditions : results of 12 months in situ-measurements at Kortrijk ECO-Life community

In a recently built zero-carbon neighborhood, demand controlled exhaust ventilation systems (DCMEV) and mechanical ventilation systems with heat recovery (MVHR) are compared under operational conditions, with focus on the energy performance of both systems. The analysis is based on automatically gathered monitoring data, complementary in situ measurements and occupants surveys. This paper comments on both ventilation systems and their energy saving potential according to literature. In this case study, demand controlled ventilation the electricity use of the system proved to be lower, heating demand proves to be comparable and the IAQ seems to be comparable. When taking into account the electricity and heating prices, the total cost or net present value of the DCMEV system is nearly a third lower than that of the MVHR system, partly due to a higher investment and maintenance cost of the latter. Further research should focus on the carbon footprint of ventilation systems, reliability and lifetime of sensors and the impact of regular filter cleaning/replacement in case of MVHR.
Women with Pregnancies Had Lower Adherence to 1% Tenofovir Vaginal Gel as HIV Preexposure Prophylaxis in CAPRISA 004, a Phase IIB Randomized-Controlled Trial

Background Antiretroviral prophylaxis may be a critical strategy to reduce periconception HIV transmission. Maximizing the benefit of periconception pharmacologic HIV risk-reduction requires an understanding of the links between pregnancy and adherence to this prevention strategy. Methods We assessed study gel adherence among women with pregnancies compared to women without pregnancies enrolled in the CAPRISA 004 phase IIB trial of 1% vaginal tenofovir gel. Pregnancy was assessed with monthly urine tests. Adherence was measured monthly and defined as proportion of sex acts covered by two returned, used applicators based on pre- and post-coital dosing. High adherence was defined as a median adherence score of >80%, that is, more than 80% of sex acts were covered by two applications of study gel. A multivariate generalized estimating equations (GEE) model with a binomial distribution was used to assess covariates associated with high adherence (>80%) over time. Median adherence before and after pregnancy was compared using Wilcoxon signed rank test. Results Among 868 women, 53 had at least 1 pregnancy (4.06 per 100 woman years, 95% CI: 3.04, 5.31). Women with pregnancies had lower median adherence compared to women without pregnancies (50% [IQR: 45–83] vs. 60% [IQR: 50–100], p = 0.02). Women with pregnancies also had a 48% lower odds of high adherence compared to women without pregnancies when adjusting for confounders (aOR 0.52, 95%CI: 0.41–0.66, p<0.0001). Among women with pregnancies, adherence before and after pregnancy was not different (50% [IQR: 46–83] vs. 55% [IQR: 20–100], p = 0.68). Conclusions Women with pregnancies were less likely to have high adherence to study gel compared to women without pregnancies. Understanding these differences may inform findings from HIV prevention trials and future implementation of antiretroviral prophylaxis for at-risk women who choose to conceive. The protocol for the parent trial is registered on ClinicalTrials.gov, NCT00441298, http://www.clinicaltrials. gov/ct2/show/NCT00441298.
Life expectancy and years of life lost in chronic obstructive pulmonary disease: Findings from the NHANES III Follow-up Study

Rationale Previous studies have demonstrated that chronic obstructive pulmonary disease (COPD) causes increased mortality in the general population. But life expectancy and the years of life lost have not been reported. Objectives To quantify mortality, examine how it varies with age, sex, and other risk factors, and determine how life expectancy is affected. Methods We constructed mortality models using the Third National Health and Nutrition Examination Survey, adjusting for age, sex, race, and major medical conditions. We used these to compute life expectancy and the years of life lost. Measurements and main results Pulmonary function testing classified patients as having Global Initiative on Obstructive Lung Disease (GOLD) stage 0, 1, 2, 3 or 4 COPD or restriction. COPD is associated with only a modest reduction in life expectancy for never smokers, but with a very large reduction for current and former smokers. At age 65, the reductions in male life expectancy for stage 1, stage 2, and stages 3 or 4 disease in current smokers are 0.3 years, 2.2 years, and 5.8 years. These are in addition to the 3.5 years lost due to smoking. In former smokers the reductions are 1.4 years and 5.6 years for stage 2 and stages 3 or 4 disease, and in never smokers they are 0.7 and 1.3 years. Conclusions Persons with COPD have an increased risk of mortality compared to those who do not, with consequent reduction in life expectancy. The effect is most marked in current smokers, and this is further reason for smokers to quit.
t-BHQ Provides Protection against Lead Neurotoxicity via Nrf2/HO-1 Pathway

The neurotoxicity of lead has been well established, and oxidative stress is strongly associated with lead-induced neurotoxicity. Nrf2 is important for protection against oxidative stress in many disease models. We applied t-BHQ, which is an Nrf2 activator, to investigate the possible role of Nrf2 in the protection against lead neurotoxicity. t-BHQ significantly attenuated the oxidative stress in developmental rats by decreasing MDA level, as well as by increasing SOD activity and GSH content, in the hippocampus and frontal cortex. Furthermore, neuronal apoptosis was detected by Nissl staining, and Bax expression was inhibited in the t-BHQ-treated group. Results showed that t-BHQ suppressed ROS production and caspase 3/7 activity but increased intracellular GSH content, in SH-SY5Y cells under lead exposure. Moreover, in vivo and in vitro, t-BHQ enhanced the nuclear translocation of Nrf2 and binding to ARE areas but did not induce Nrf2 transcription. These phenomena were confirmed using RT-PCR, EMSA, Western blot, and immunofluorescence analyses. Subsequent upregulation of the expression of HO-1, NQO1, and GCLC was observed. However, knockdown of Nrf2 or HO-1 adversely affected the protective effects of t-BHQ against lead toxicity in SH-SY5Y cells. Thus, t-BHQ can protect against lead neurotoxicity, depending on the Nrf2/HO-1 pathway.