Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Whole-Body Cryotherapy vs. Far-Infrared vs. Passive Modalities on Recovery from Exercise-Induced Muscle Damage in Highly-Trained Runners

Enhanced recovery following physical activity and exercise-induced muscle damage (EIMD) has become a priority for athletes. Consequently, a number of post-exercise recovery strategies are used, often without scientific evidence of their benefits. Within this framework, the purpose of this study was to test the efficacy of whole body cryotherapy (WBC), far infrared (FIR) or passive (PAS) modalities in hastening muscular recovery within the 48 hours after a simulated trail running race. In 3 non-adjoining weeks, 9 well-trained runners performed 3 repetitions of a simulated trail run on a motorized treadmill, designed to induce muscle damage. Immediately (post), post 24 h, and post 48 h after exercise, all participants tested three different recovery modalities (WBC, FIR, PAS) in a random order over the three separate weeks. Markers of muscle damage (maximal isometric muscle strength, plasma creatine kinase [CK] activity and perceived sensations [i.e. pain, tiredness, well-being]) were recorded before, immediately after (post), post 1 h, post 24 h, and post 48 h after exercise. In all testing sessions, the simulated 48 min trail run induced a similar, significant amount of muscle damage. Maximal muscle strength and perceived sensations were recovered after the first WBC session (post 1 h), while recovery took 24 h with FIR, and was not attained through the PAS recovery modality. No differences in plasma CK activity were recorded between conditions. Three WBC sessions performed within the 48 hours after a damaging running exercise accelerate recovery from EIMD to a greater extent than FIR or PAS modalities.
Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival

The Pit1-Oct1-Unc86 domain (POU domain) transcription factor Brn3a controls sensory neuron survival by regulating the expression of Trk receptors and members of the Bcl-2 family. Loss of Brn3a leads to a dramatic increase in apoptosis and severe loss of neurons in sensory ganglia. Although recent evidence suggests that Brn3a-mediated transcription can be modified by additional cofactors, the exact mechanisms are not known. Here, we report that homeodomain interacting protein kinase 2 (HIPK2) is a pro-apoptotic transcriptional cofactor that suppresses Brn3a-mediated gene expression. HIPK2 interacts with Brn3a, promotes Brn3a binding to DNA, but suppresses Brn3a-dependent transcription of brn3a, trkA, and bcl-x L. Overexpression of HIPK2 induces apoptosis in cultured sensory neurons. Conversely, targeted deletion of HIPK2 leads to increased expression of Brn3a, TrkA, and Bcl-xL, reduced apoptosis and increases in neuron numbers in the trigeminal ganglion. Together, these data indicate that HIPK2, through regulation of Brn3a-dependent gene expression, is a critical component in the transcriptional machinery that controls sensory neuron survival.
Influence of prior knowledge on concept acquisition: Experimental and computational results.

Author(s): Pazzani, Michael J. | Abstract: The influence of the prior causal knowledge of subjects on the rate of learning, the categories formed, and the attributes attended to during learning is explored. Conjunctive concepts are thought to be easier for subjects to learn than disjunctive concepts. Conditions are reported under which the opposite occurs. In particular, it is demonstrated that prior knowledge can influence the rate of concept learning and that the influence of prior causal knowledge can dominate the influence of the logical form. A computational model of this learning task is presented. In order to represent the prior knowledge of the subjects, an extension to explanation-based learning is developed to deal with imprecise domain knowledge.
Uptake of a Fluorescent Marker in Plant Cells Is Sensitive to Brefeldin A and Wortmannin Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.010339.

We assessed FM1-43 [N-(3-triethylammoniumpropyl)-4-(4-[dibutylamino]styryl)pyridinium dibromide] as a fluorescent endocytosis marker in intact, walled plant cells. At 4°C, FM1-43 stained the plasma membrane, and after 30 to 120 min of incubation at 26°C, FM1-43 labeled cytoplasmic vesicles and then the vacuole. Fluorimetric quantitation demonstrated dye uptake temperature sensitivity (∼65% reduction at 16°C, >90% at 4°C). FM1-43 uptake in suspension cells was stimulated more than twofold by brefeldin A and inhibited ∼0.4-fold by wortmannin. FM1-43 delivery to the vacuole was largely inhibited by brefeldin A, although overall uptake was stimulated, and brefeldin A treatment caused the accumulation of large prevacuolar endosomal vesicles heavily labeled with FM1-43. Three-dimensional time lapse imaging revealed that FM1-43–labeled vacuoles and vesicles are highly dynamic. Thus, FM1-43 serves as a fluorescent marker for imaging and quantifying membrane endocytosis in intact plant cells.
Cytotoxic and molecular chemotherapy for high-grade glioma: an emerging strategy for the future

Maximal surgical debulking and radiotherapy have been the cornerstone of therapy for high-grade gliomas. The impact of chemotherapy on outcome has been marginal and, until recently, its usage has been debatable. The development of new drugs and an improved understanding of chemoresistance have reinvigorated interest in this treatment modality. Furthermore, increasing knowledge of gliomagenesis has also led to novel non-cytotoxic approaches to targeting the molecular machinery that is responsible for tumour development and progression. These new strategies, which are currently being evaluated in clinical trials, provide new hope for the future.
Update on treatment options for Lambert–Eaton myasthenic syndrome: focus on use of amifampridine

In Lambert–Eaton myasthenic syndrome (LEMS), antibodies against presynaptic voltage-gated calcium channels reduce the quantal release of acetylcholine, causing muscle weakness and autonomic dysfunction. More than half of the affected patients have associated small cell lung cancer, and thorough screening for an underlying malignancy is crucial. The mainstay of treatment for LEMS is symptomatic but immunotherapy is needed in more severely affected patients. Symptomatic therapies aim at increasing the concentration of acetylcholine at the muscle endplate. While acetylcholinesterase inhibitors were the first drugs to be used for the amelioration of symptoms, 3,4-diaminopyridine (3,4-DAP, amifampridine) has been shown to be more effective. 3,4-DAP blocks presynaptic potassium channels, thereby prolonging the action potential and increasing presynaptic calcium concentrations. This then results in increased quantal release of acetylcholine. The efficacy of 3,4-DAP for increasing muscle strength and resting compound muscle action potentials has been demonstrated by four placebo-controlled trials. Side effects are usually mild, and the most frequently reported are paresthesias. The most common serious adverse events are epileptic seizures. 3,4-DAP is currently the treatment of choice in patients with Lambert–Eaton myasthenic syndrome.
Multinodular Goiter: A Study of Malignancy Risk in Nondominant Nodules

The long-standing belief that multinodular goiters are associated with a lower risk of developing into carcinoma has been challenged by the results of some recent studies. In addition, we have noticed in our practice that a sizable proportion of cancers have been arising from nondominant nodules. We performed a retrospective study of 223 cases to determine (1) the incidence of carcinoma in multinodular goiters that required surgical management in our local, predominantly Asian population and (2) the incidence of carcinoma arising from nondominant nodules. We reviewed the records of all patients with a multinodular goiter who had undergone a thyroidectomy over a period of more than 10 years in our Department of Otolaryngology–Head and Neck Surgery. We examined the histopathology reports for (1) the presence of carcinoma, (2) whether the carcinoma was isolated/unifocal or multifocal, (3) the histologic type of cancer, and (4) whether the isolated/unifocal cancers arose from the dominant or nondominant nodule. Our study population was made up of 47 males and 176 females, aged 15 to 90 years (mean: 53). We found that the incidence of malignancy in surgically treated multinodular goiters was 14.3% (32 of 223 patients). Of the 32 malignancies, 18 (56.3%) were isolated/unifocal and 14 (43.8%) were multifocal. In the isolated/unifocal group, 9 malignancies (50.0%) arose from nondominant nodules and 8 (44.4%) from dominant nodules; in the remaining case, the nodule of origin could not be determined. Our findings corroborate those in the recent literature in that the risk of malignancy associated with multinodular goiters is comparable to that of single thyroid nodules. We recommend that physicians be equally vigilant when monitoring dominant and nondominant nodules.
Migratory Sleeplessness in the White-Crowned Sparrow (Zonotrichia leucophrys gambelii)

Twice a year, normally diurnal songbirds engage in long-distance nocturnal migrations between their wintering and breeding grounds. If and how songbirds sleep during these periods of increased activity has remained a mystery. We used a combination of electrophysiological recording and neurobehavioral testing to characterize seasonal changes in sleep and cognition in captive white-crowned sparrows (Zonotrichia leucophrys gambelii) across nonmigratory and migratory seasons. Compared to sparrows in a nonmigratory state, migratory sparrows spent approximately two-thirds less time sleeping. Despite reducing sleep during migration, accuracy and responding on a repeated-acquisition task remained at a high level in sparrows in a migratory state. This resistance to sleep loss during the prolonged migratory season is in direct contrast to the decline in accuracy and responding observed following as little as one night of experimenter-induced sleep restriction in the same birds during the nonmigratory season. Our results suggest that despite being adversely affected by sleep loss during the nonmigratory season, songbirds exhibit an unprecedented capacity to reduce sleep during migration for long periods of time without associated deficits in cognitive function. Understanding the mechanisms that mediate migratory sleeplessness may provide insights into the etiology of changes in sleep and behavior in seasonal mood disorders, as well as into the functions of sleep itself.
Vandermonde-subspace frequency division multiplexing receiver analysis

Vandermonde-subspace frequency division multiplexing (VFDM) is a technique for interference cancellation in overlay networks that allows a secondary network to operate simultaneously with a primary network, on the same frequency band. VFDM can be applied to block transmission systems with a guard time (or cyclic prefix) over frequency selective channels. It achieves zero interference towards the primary system by employing a special precoder that aligns the data to the null space of the interfering channel from the secondary to the primary system. In this work, we extend the assessment of VFDM by analyzing the bit error rate and sum rate capacity of practical linear receiver structures for the VFDM-based secondary system. The study realized herein serves as a basis for the implementation of a VFDM prototype system on a real transmission testbed.
Stochastic Geometry Based Cell Load Analysis in Heterogeneous Networks

In this paper, we propose a mathematical framework for downlink heterogeneous networks (HetNets) involving cell load factors, which measure the average resource consumption. Due to mutual interference, the cell load levels of different tiers are in general coupled with each other in a nonlinear manner. By leveraging tools from stochastic geometry, we compute the average cell load levels across tiers via fixed-point equations that are dependent upon network parameters (e.g., deployment density, transmit power, association bias) and users' data demands. As an exemplary application of the proposed model, the effect of the association bias on achieving balanced network loads is investigated in two-tier networks. The optimum association bias factor, although not expressed in closed form, can be found efficiently through the standard bisection search method. Numerical results show that in the feasible load region, the previous cell load estimation based on worst-case SIR (signal-to-interference ratio) gives an upper bound on the cell load levels derived in this paper. In addition, the effectiveness of the proposed optimum bias adaptation for the purpose of load balancing is demonstrated by simulation.
A matrix-algebraic approach to successive interference cancellation in CDMA

In this paper, we describe linear successive interference cancellation (SIC) based on matrix-algebra. We show that linear SIC schemes (single stage and multistage) correspond to linear matrix filtering that can be performed directly on the received chip-matched filtered signal vector without explicitly performing the interference cancellation. This leads to an analytical expression for calculating the resulting bit-error rate which is of particular use for short code systems. Convergence issues are discussed, and the concept of /spl epsiv/-convergence is introduced to determine the number of stages required for practical convergence for both short and long codes.
Code Ownership and Software Quality: A Replication Study

In a traditional sense, ownership determines rights and duties in regard to an object, for example a property. The owner of source code usually refers to the person that invented the code. However, larger code artifacts, such as files, are usually composed by multiple engineers contributing to the entity over time through a series of changes. Frequently, the person with the highest contribution, e.g. The most number of code changes, is defined as the code owner and takes responsibility for it. Thus, code ownership relates to the knowledge engineers have about code. Lacking responsibility and knowledge about code can reduce code quality. In an earlier study, Bird et al. [1] showed that Windows binaries that lacked clear code ownership were more likely to be defect prone. However recommendations for large artifacts such as binaries are usually not actionable. E.g. Changing the concept of binaries and refactoring them to ensure strong ownership would violate system architecture principles. A recent replication study by Foucault et al. [2] on open source software replicate the original results and lead to doubts about the general concept of ownership impacting code quality. In this paper, we replicated and extended the previous two ownership studies [1, 2] and reflect on their findings. Further, we define several new ownership metrics to investigate the dependency between ownership and code quality on file and directory level for 4 major Microsoft products. The results confirm the original findings by Bird et al. [1] that code ownership correlates with code quality. Using new and refined code ownership metrics we were able to classify source files that contained at least one bug with a median precision of 0.74 and a median recall of 0.38. On directory level, we achieve a precision of 0.76 and a recall of 0.60.
CBL Is Frequently Altered in Lung Cancers: Its Relationship to Mutations in MET and EGFR Tyrosine Kinases

Background Non-small cell lung cancer (NSCLC) is a heterogeneous group of disorders with a number of genetic and proteomic alterations. c-CBL is an E3 ubiquitin ligase and adaptor molecule important in normal homeostasis and cancer. We determined the genetic variations of c-CBL, relationship to receptor tyrosine kinases (EGFR and MET), and functionality in NSCLC. Methods and Findings Using archival formalin-fixed paraffin embedded (FFPE) extracted genomic DNA, we show that c-CBL mutations occur in somatic fashion for lung cancers. c-CBL mutations were not mutually exclusive of MET or EGFR mutations; however they were independent of p53 and KRAS mutations. In normal/tumor pairwise analysis, there was significant loss of heterozygosity (LOH) for the c-CBL locus (22%, n = 8/37) and none of these samples revealed any mutation in the remaining copy of c-CBL. The c-CBL LOH also positively correlated with EGFR and MET mutations observed in the same samples. Using select c-CBL somatic mutations such as S80N/H94Y, Q249E and W802* (obtained from Caucasian, Taiwanese and African-American samples, respectively) transfected in NSCLC cell lines, there was increased cell viability and cell motility. Conclusions Taking the overall mutation rate of c-CBL to be a combination as somatic missense mutation and LOH, it is clear that c-CBL is highly mutated in lung cancers and may play an essential role in lung tumorigenesis and metastasis.
A 1-Gb/s flexible LDPC decoder supporting multiple code rates and block lengths

This paper propose a new flexible low-density parity-check (LDPC) decoding architecture that can be dynamically reconfigured according to a parity-check matrix which changes as code rate or block length varies. Since the LDPC codes are adopted in standards such as DVB-S2, IEEE 802.1 In and IEEE 802.16e and each standard allows various code rates and block lengths, an LDPC decoder architecture that could support multiple code rates and code block lengths is needed. The proposed architecture employs Benes network to implement configurable interconnection network. In the proposed architecture the number of levels and the delay of the interconnection network is reduced by using broadcasting technique which transmits reduced messages to save the complexity of the interconnection network. The number of processing units in the proposed partially parallel architecture is determined by investigating the relation between hardware complexity and throughput. By applying pipelining to the processing units, decoding throughput is increased. To verify the proposed architecture, a flexible LDPC decoder is implemented using a 0.18 mum CMOS process. The decoder occupies an area of 16.261 mm and runs correctly at the frequency of 212 MHz resulting in 1 Gbps decoding throughput.
Seismicity and structure in central Mexico: Evidence for a possible slab tear in the South Cocos plate

The morphology of the transition from flat to normal subduction in eastern central Mexico is explored using intraslab earthquakes recorded by temporary and permanent regional seismic arrays. Observations of a sharp transition in slab dip near the abrupt end of the Trans‐Mexican Volcanic Belt (TMVB) suggest a possible slab tear located within the subducted South Cocos plate. The eastern lateral extent of a thin ultra‐slow velocity layer (USL) imaged atop the Cocos slab in recent studies along the Meso America Subduction Experiment array is examined here using additional data. We find an end to this USL which is coincident with the western boundary of a zone of decreased seismicity and the end of the TMVB near the sharp transition in slab dip. Waveform modeling of the 2‐D structure in this region using a finite difference algorithm provides constraints on the velocity and geometry of the slab's seismic structure and confirms the location of the USL. Analysis of intraslab seismicity patterns reveals clustering, sudden increase in depth, variable focal mechanism orientations and faulting types, and alignment of source mechanisms along the sharp transition in slab dip. The seismicity and structural evidence suggests a possible tear in the South Cocos slab. This potential tear, together with the tear along the Orozco Fracture Zone to the northwest, indicates a slab rollback mechanism in which separate slab segments move independently, allowing for mantle flow between the segments.
Pathophysiology of Coronary Artery Disease

During the past decade, our understanding of the pathophysiology of coronary artery disease (CAD) has undergone a remarkable evolution. We review here how these advances have altered our concepts of and clinical approaches to both the chronic and acute phases of CAD. Previously considered a cholesterol storage disease, we currently view atherosclerosis as an inflammatory disorder. The appreciation of arterial remodeling (compensatory enlargement) has expanded attention beyond stenoses evident by angiography to encompass the biology of nonstenotic plaques. Revascularization effectively relieves ischemia, but we now recognize the need to attend to nonobstructive lesions as well. Aggressive management of modifiable risk factors reduces cardiovascular events and should accompany appropriate revascularization. We now recognize that disruption of plaques that may not produce critical stenoses causes many acute coronary syndromes (ACS). The disrupted plaque represents a “solid-state” stimulus to thrombosis. Alterations in circulating prothrombotic or antifibrinolytic mediators in the “fluid phase” of the blood can also predispose toward ACS. Recent results have established the multiplicity of “high-risk” plaques and the widespread nature of inflammation in patients prone to develop ACS. These findings challenge our traditional view of coronary atherosclerosis as a segmental or localized disease. Thus, treatment of ACS should involve 2 overlapping phases: first, addressing the culprit lesion, and second, aiming at rapid “stabilization” of other plaques that may produce recurrent events. The concept of “interventional cardiology” must expand beyond mechanical revascularization to embrace preventive interventions that forestall future events.
Variational time integrators

The purpose of this paper is to review and further develop the subject of variational integration algorithms as it applies to mechanical systems of engineering interest. In particular, the conservation properties of both synchronous and asynchronous variational integrators (AVIs) are discussed in detail. We present selected numerical examples which demonstrate the excellent accuracy, conservation and convergence characteristics of AVIs. In these tests, AVIs are found to result in substantial speed‐ups, at equal accuracy, relative to explicit Newmark. A mathematical proof of convergence of the AVIs is also presented in this paper. Finally, we develop the subject of horizontal variations and configurational forces in discrete dynamics. This theory leads to exact path‐independent characterizations of the configurational forces acting on discrete systems. Notable examples are the configurational forces acting on material nodes in a finite element discretisation; and the J‐integral at the tip of a crack in a finite element mesh. Copyright © 2004 John Wiley & Sons, Ltd.
The Geometry of Rank Decompositions of Matrix Multiplication I: 2 × 2 Matrices

ABSTRACT This is the first in a series of papers on rank decompositions of the matrix multiplication tensor. In this paper, we establish general facts about rank decompositions of tensors, describe potential ways to search for new matrix multiplication decompositions, give a geometric proof of the theorem of Burichenko establishing the symmetry group of Strassen's algorithm, and present two particularly nice subfamilies in the Strassen family of decompositions.