Miracle-dz/UniFAR-FTUs huggingface dataset:
Usability assessment of natural user interfaces during serious games: Adjustments for dementia intervention

Serious games based rehabilitation program needs a comprehensive and people-centred design for a better efficacy. In most studies benchmarking the computer-interaction interfaces is a prerequisite for adjusting the most appropriate user input for the rehabilitation application. The present study examines a comparison between three natural user interfaces and two standard computer interfaces in two different virtual reality tasks. The results illustrate that the acceptance and user-friendliness of a device regarding the completion of a specific task strongly depends on the task itself and on the abilities of the users.
Diagnosis of acute pulmonary histoplasmosis by antigen detection.

BACKGROUND Antigen detection, which has proven useful in diagnosis of disseminated histoplasmosis, has not been studied in acute pulmonary histoplasmosis (APH). Because treatment is indicated in most patients with moderately severe or severe APH, antigen detection for rapid diagnosis could be helpful. METHODS Histoplasma antigen detection was evaluated in 130 patients with APH. RESULTS Antigenuria was detected in 64.6%, antigenemia in 68.6%, and antibody in 64.3%. If both urine and serum specimens were tested, antigen was detected in 82.8%, of which 45.8% had antigenemia only; and if both antigen and antibody were measured, results were positive in 93.3%, of which antigen only was positive in 35.7%. CONCLUSIONS Testing for antigenemia, antigenuria, and antibodies using the complement fixation test offers a sensitive, noninvasive method for diagnosis of APH.
Memória visuo-espacial a curto prazo: os efeitos da supressão articulatória e de uma tarefa aritmética

We investigated the nature of the information stored in visuo-spatial short-term memory in two experiments. In the first experiment, a spatial localization task was performed simultaneously with articulatory suppression and arithmetical subtraction tasks. The articulatory suppression has a negative effect on the performance with letters, but not with visual patterns. Despite that, the recall of the letters is better than the recall of the visual patterns. This result suggests that the storage of the visual patterns does not use the phonological loop, and that the articulatory suppression, even if it inhibits the use of the phonological loop, cannot inhibit the access to the semantic information. In the second experiment we established the effect of the visual similarity on the capacity of memory for the spatial position. The results confirm the use of visual codes and suggest that the storage capacity of the visual stimuli is limited, but not restricted to the recency items.
Combined image- and world-space tracking in traffic scenes

Tracking in urban street scenes plays a central role in autonomous systems such as self-driving cars. Most of the current vision-based tracking methods perform tracking in the image domain. Other approaches, e.g. based on LIDAR and radar, track purely in 3D. While some vision-based tracking methods invoke 3D information in parts of their pipeline, and some 3D-based methods utilize image-based information in components of their approach, we propose to use image- and world-space information jointly throughout our method. We present our tracking pipeline as a 3D extension of image-based tracking. From enhancing the detections with 3D measurements to the reported positions of every tracked object, we use world-space 3D information at every stage of processing. We accomplish this by our novel coupled 2D-3D Kalman filter, combined with a conceptually clean and extendable hypothesize-and-select framework. Our approach matches the current state-of-the-art on the official KITTI benchmark, which performs evaluation in the 2D image domain only. Further experiments show significant improvements in 3D localization precision by enabling our coupled 2D-3D tracking.
Dispersive coupling between light and a rare-earth ion doped mechanical resonator

By spectrally hole burning an inhomogeneously broadened ensemble of ions while applying a controlled perturbation, one can obtain spectral holes that are functionalized for maximum sensitivity to different perturbations. We propose to use such hole burnt structures for the dispersive optical interaction with rare-earth ion dopants whose frequencies are sensitive to crystal strain due to the bending motion of a crystal cantilever. A quantitative analysis shows that good optical sensitivity to the bending motion is obtained if a magnetic field gradient is applied across the crystal during hole burning, and that the resulting opto-mechanical coupling strength is sufficient for observing quantum features such as zero point vibrations.
Pseudoscalar meson physics with four dynamical quarks

We present preliminary results for light, strange and charmed pseudoscalar meson physics from simulations using four flavors of dynamical quarks with the highly improved staggered quark (HISQ) action. These simulations include lattice spacings ranging from 0.15 to 0.06 fm, and seaquark masses both above and at their physical value. The major results are charm meson decay constants fD, fDs and fDs = fD and ratios of quark masses. This talk will focus on our procedures for finding the decay constants on each ensemble, the continuum extrapolation, and estimates of systematic error.
Research Methods in Health

The new edition of Research Methods in Healthcontinues to provide an excellent broad based introduction to the subject. New or expanded sections, for example on the evaluation of complex interventions, mixed research methods, life history interviews, and socio-psychological theories make this third edition well worth purchasing. The content is clearly presented and at a suitable level for its intended audience of health professionals and post-graduate students in health and health-related social sciences. " . Virginia Berridge, London School of Hygiene and Tropical Medicine, UK. This bestselling book provides an accessible introduction to the theoretical concepts and descriptive and analytic research methods used in research on health and health services. The third edition has been thoroughly revised throughout to include updated references and boxed examples, with additional information on key methodological developments, among them: Complex interventions, Mixed research methods, Psychometrics, Secondary data analysis, Systematic reviews, Pertinent social science concepts. The research methods described cover the assessment of health needs, morbidity and mortality trends and rates, costing health services, sampling for survey research, cross-sectional and longitudinal survey design, experimental methods and techniques of group assignment, questionnaire design, interviewing techniques, coding and analysis of quantitative data, methods and analysis of qualitative observational studies, and types of unstructured interviewing. The book is grounded in the authors career as a researcher on health and health service issues, and the valuable experience this has provided in meeting the challenges of research on people and organisations in real life settings.Research Methods in Healthis an essential companion for students and researchers of health and health services, health clinicians and policy-makers with responsibility for applying research findings and judging the soundness of research
Person–Organization Fit and Contextual Performance: Do Shared Values Matter☆☆☆

Abstract The influence of person–organization fit on employees' task and contextual performance was investigated in this study. It was hypothesized that the fit between employees' desired organizational cultures and their actual organizational cultures would predict contextual performance (e.g., helping behaviors toward other employees or the organization). It was found that (1) perceptions of the organizational culture and (2) the discrepancy between employees' ideal organizational culture and their perceptions of the actual organizational culture were important in predicting both contextual performance and task performance. Implications of these findings for organizational research and human resource management practice are presented.
Beyond Male and Female: Poststructuralism and the Spectrum of Gender

ABSTRACT Transgender explodes the notion that male and female are discrete categories. Transgender people change sex or inhabit third (or multiple) sex, androgynous, or fluid identities. I theorize this by developing and then critiquing poststructuralist transgender theory. A poststructuralist theory of transgender disassociates sex and gender, models both as constructed, and emphasizes the technologisation and commodification of the body. Poststructuralist accounts can, however, entail denial of bodily limitations, erase transgender people's subjective experience, and overlook social and political factors, such as the importance of gender categories as a basis for identity politics. I argue for the deconstruction of gender binaries to be combined with the development of a gender-pluralist, flexible, model of gender. This points to the replacement of bipolar models of gender with a gender spectrum, with important implications for conceptualizing gender. My analysis is based on empirical research with a range of transgender people.
THE ‘SOCIAL IMPLICATIONS’ FACTOR IN ATTITUDES TO SCIENCE

Summary. Subject and social implications factors have been identified in a science attitude test applied to the more able half of the 13–14 year age group in a sample of English secondary schools. The relationship between attitudes about the social implications of science and choice for or against a science option appears to be stronger in the case of girls than in the case of boys.
The interface of protein structure, protein biophysics, and molecular evolution

Abstract The interface of protein structural biology, protein biophysics, molecular evolution, and molecular population genetics forms the foundations for a mechanistic understanding of many aspects of protein biochemistry. Current efforts in interdisciplinary protein modeling are in their infancy and the state‐of‐the art of such models is described. Beyond the relationship between amino acid substitution and static protein structure, protein function, and corresponding organismal fitness, other considerations are also discussed. More complex mutational processes such as insertion and deletion and domain rearrangements and even circular permutations should be evaluated. The role of intrinsically disordered proteins is still controversial, but may be increasingly important to consider. Protein geometry and protein dynamics as a deviation from static considerations of protein structure are also important. Protein expression level is known to be a major determinant of evolutionary rate and several considerations including selection at the mRNA level and the role of interaction specificity are discussed. Lastly, the relationship between modeling and needed high‐throughput experimental data as well as experimental examination of protein evolution using ancestral sequence resurrection and in vitro biochemistry are presented, towards an aim of ultimately generating better models for biological inference and prediction.
A Five-Year Survey of Dematiaceous Fungi in a Tropical Hospital Reveals Potential Opportunistic Species

Dematiaceous fungi (black fungi) are a heterogeneous group of fungi present in diverse environments worldwide. Many species in this group are known to cause allergic reactions and potentially fatal diseases in humans and animals, especially in tropical and subtropical climates. This study represents the first survey of dematiaceous fungi in Malaysia and provides observations on their diversity as well as in vitro response to antifungal drugs. Seventy-five strains isolated from various clinical specimens were identified by morphology as well as an internal transcribed spacer (ITS)-based phylogenetic analysis. The combined molecular and conventional approach enabled the identification of three classes of the Ascomycota phylum and 16 genera, the most common being Cladosporium, Cochliobolus and Neoscytalidium. Several of the species identified have not been associated before with human infections. Among 8 antifungal agents tested, the azoles posaconazole (96%), voriconazole (90.7%), ketoconazole (86.7%) and itraconazole (85.3%) showed in vitro activity (MIC ≤1 µg/mL) to the largest number of strains, followed by anidulafungin (89.3%), caspofungin (74.7%) and amphotericin B (70.7%). Fluconazole appeared to be the least effective with only 10.7% of isolates showing in vitro susceptibility. Overall, almost half (45.3%) of the isolates showed reduced susceptibility (MIC >1 µg/mL) to at least one antifungal agent, and three strains (one Pyrenochaeta unguis-hominis and two Nigrospora oryzae) showed potential multidrug resistance.
Metaphor, poetry, storytelling and cross‐cultural leadership

Purpose – The purpose of this paper is to describe the theory and benefits of poetry, storytelling, and metaphor when applied to cross‐cultural leadership.Design/methodology/approach – The methodology utilized is founded on preliminary research on metaphors, poetry and leadership with examples and connections based upon experience.Findings – Explains how the use of poetry and metaphors can be utilized by a leader to build trust and demonstrate empathy; how to communicate more effectively; and, how to inspire.Research limitations/implications – Possible future research on the psychological and sociological aspects of the messages that most impel, mobilize, and inspire people to act on complex ideas.Practical implications – Leaders can approach communications, empathy, and trust with a tool that will enable them to inspire action in complex cultural environments.Originality/value – There has been little published on the connection between effective leadership and the use of poetry and metaphor. Leadership r.
Participation in Voluntary Associations on a Working Class Housing Estate

status join voluntary associations more frequently than people of lower status (cf. Hausknecht, 1962). However studies of this kind fail to explain variations in membership rates within S.E. S. sets (Ross, 1972: 27). They rarely ask people why they are involved in groups and what they get out of it. This question of interests was stressed by Bryson and Thompson (1972) in their study of a working-class suburb in Melbourne and they found a conflict of interests in the group life of the suburb. The conflict was between the predominantly professional participants based in the welfare agencies and civic groups, and the predominantly workingclass participants in the sports and childen’s groups. The former claimed to be interested in participation for its own sake, as a means of developing an active, con-
Effect of 3 to 5 years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer: the FACS randomized clinical trial.

IMPORTANCE Intensive follow-up after surgery for colorectal cancer is common practice but is based on limited evidence. OBJECTIVE To assess the effect of scheduled blood measurement of carcinoembryonic antigen (CEA) and computed tomography (CT) as follow-up to detect recurrent colorectal cancer treatable with curative intent. DESIGN, SETTING, AND PARTICIPANTS Randomized clinical trial in 39 National Health Service hospitals in the United Kingdom; 1202 eligible participants were recruited between January 2003 and August 2009 who had undergone curative surgery for primary colorectal cancer, including adjuvant treatment if indicated, with no evidence of residual disease on investigation. INTERVENTIONS Participants were randomly assigned to 1 of 4 groups: CEA only (n = 300), CT only (n = 299), CEA+CT (n = 302), or minimum follow-up (n = 301). Blood CEA was measured every 3 months for 2 years, then every 6 months for 3 years; CT scans of the chest, abdomen, and pelvis were performed every 6 months for 2 years, then annually for 3 years; and the minimum follow-up group received follow-up if symptoms occurred. MAIN OUTCOMES AND MEASURES The primary outcome was surgical treatment of recurrence with curative intent; secondary outcomes were mortality (total and colorectal cancer), time to detection of recurrence, and survival after treatment of recurrence with curative intent. RESULTS After a mean 4.4 (SD, 0.8) years of observation, cancer recurrence was detected in 199 participants (16.6%; 95% CI, 14.5%-18.7%) overall; 71 of 1202 participants (5.9%; 95% CI, 4.6%-7.2%) were treated for recurrence with curative intent, with little difference according to Dukes staging (stage A, 5.1% [13/254]; stage B, 6.1% [34/553]; stage C, 6.2% [22/354]). Surgical treatment of recurrence with curative intent was 2.3% (7/301) in the minimum follow-up group, 6.7% (20/300) in the CEA group, 8% (24/299) in the CT group, and 6.6% (20/302) in the CEA+CT group. Compared with minimum follow-up, the absolute difference in the percentage of patients treated with curative intent in the CEA group was 4.4% (95% CI, 1.0%-7.9%; adjusted odds ratio [OR], 3.00; 95% CI, 1.23-7.33), in the CT group was 5.7% (95% CI, 2.2%-9.5%; adjusted OR, 3.63; 95% CI, 1.51-8.69), and in the CEA+CT group was 4.3% (95% CI, 1.0%-7.9%; adjusted OR, 3.10; 95% CI, 1.10-8.71). The number of deaths was not significantly different in the combined intensive monitoring groups (CEA, CT, and CEA+CT; 18.2% [164/901]) vs the minimum follow-up group (15.9% [48/301]; difference, 2.3%; 95% CI, -2.6% to 7.1%). CONCLUSIONS AND RELEVANCE Among patients who had undergone curative surgery for primary colorectal cancer, intensive imaging or CEA screening each provided an increased rate of surgical treatment of recurrence with curative intent compared with minimal follow-up; there was no advantage in combining CEA and CT. If there is a survival advantage to any strategy, it is likely to be small. TRIAL REGISTRATION isrctn.org Identifier: 41458548.
Effects of the new immunosuppressive agent AEB071 on human immune cells.

UNLABELLED BACKGROUND. The novel immunosuppressive agent AEB071 is currently being evaluated for its capability to prevent rejection after kidney transplantation as a potential adjunct to calcineurin inhibitor-based regimen. AEB071 is a selective protein kinase C inhibitor and has been shown to be well tolerated in humans. We here present extensive in vitro studies that contribute to the understanding of AEB071 effects on human lymphocyte, natural killer (NK) cell and dendritic cell (DC) action. METHODS The impact of AEB071 on several T-cell activation and costimulatory markers was assessed. Furthermore, assays were performed to study the effect on T-cell proliferation and intracellular cytokine production. Additionally, the effect of AEB071 on DC maturation and their capacity to stimulate allogeneic T-cells was examined. Also, an evaluation of AEB071 effects on the lytic activity of human NK cells was performed. RESULTS We were able to show that T-cell proliferation and cytokine production rates are significantly reduced after AEB071 administration. Also, mitogen-induced T-cell activation characterized by expression levels of surface markers could be significantly inhibited. In contrast, the T-cell stimulatory capacity of AEB071-treated mature monocyte-derived DC (Mo-DC) is not reduced, and AEB071 administration does not prevent lipopolysaccharide (LPS)-induced Mo-DC maturation. It could be demonstrated that AEB071 significantly inhibited the cytotoxic activity of NK cells. CONCLUSIONS The promising immunosuppressive agent AEB071 has a strong impact on T-cell activation, proliferation and cytokine production as well as NK cell activity, but not DC maturation in vitro, and therefore, seems to function T-cell and NK cell specific via protein kinase C (PKC) inhibition.
Audit of referral of diabetic patients.

OBJECTIVE To determine the referral, the feedback rates and to find out the prevalence of diabetic retinopathy among diabetics who were referred from a primary health care center, to Abha General Hospital in Aseer Region. METHODS This study was conducted at Wasat Abha Primary Health Care Center in Aseer region at the end of 1996 and 1997. All the diabetic files were reviewed and evaluated for referral to the eye clinic, their feedback and the prevalence of diabetic retinopathy among diabetics for whom fundoscopy was carried out. The related data was entered and analyzed by using the statistical package for social sciences program. RESULTS A total of 203 diabetic files were reviewed. Forty percent were referred during 1996 while 68.5% were referred during 1997. The rates of feedback were 72% in 1996 and 71.2% in 1997. Twenty percent were referred twice during these 2 years. The prevalence of diabetic retinopathy was 11.3%. CONCLUSION The referral rate and the feedback from the eye clinic was lower than the national target. A poor referral system was responsible for such a low rate. Either reorganization of the referral system or calling the ophthalmologists to attend Primary Health Care Centers monthly will increase the rate of eye examination among diabetics and will help in early detection of diabetic retinopathy and in prevention of blindness.
Comparative Metabolic Flux Analysis of Lysine-Producing Corynebacterium glutamicum Cultured on Glucose or Fructose

ABSTRACT A comprehensive approach to 13C tracer studies, labeling measurements by gas chromatography-mass spectrometry, metabolite balancing, and isotopomer modeling, was applied for comparative metabolic network analysis of lysine-producing Corynebacterium glutamicum on glucose or fructose. Significantly reduced yields of lysine and biomass and enhanced formation of dihydroxyacetone, glycerol, and lactate in comparison to those for glucose resulted on fructose. Metabolic flux analysis revealed drastic differences in intracellular flux depending on the carbon source applied. On fructose, flux through the pentose phosphate pathway (PPP) was only 14.4% of the total substrate uptake flux and therefore markedly decreased compared to that for glucose (62.0%). This result is due mainly to (i) the predominance of phosphoenolpyruvate-dependent phosphotransferase systems for fructose uptake (PTSFructose) (92.3%), resulting in a major entry of fructose via fructose 1,6-bisphosphate, and (ii) the inactivity of fructose 1,6-bisphosphatase (0.0%). The uptake of fructose during flux via PTSMannose was only 7.7%. In glucose-grown cells, the flux through pyruvate dehydrogenase (70.9%) was much less than that in fructose-grown cells (95.2%). Accordingly, flux through the tricarboxylic acid cycle was decreased on glucose. Normalized to that for glucose uptake, the supply of NADPH during flux was only 112.4% on fructose compared to 176.9% on glucose, which might explain the substantially lower lysine yield of C. glutamicum on fructose. Balancing NADPH levels even revealed an apparent deficiency of NADPH on fructose, which is probably overcome by in vivo activity of malic enzyme. Based on these results, potential targets could be identified for optimization of lysine production by C. glutamicum on fructose, involving (i) modification of flux through the two PTS for fructose uptake, (ii) amplification of fructose 1,6-bisphosphatase to increase flux through the PPP, and (iii) knockout of a not-yet-annotated gene encoding dihydroxyacetone phosphatase or kinase activity to suppress overflow metabolism. Statistical evaluation revealed high precision of the estimates of flux, so the observed differences for metabolic flux are clearly substrate specific.