Miracle-dz/UniFAR-FTUs huggingface dataset:
Aged Female Mice B-1a Cells, and Induces Autoimmunity in Peritoneal Antigen-Specific B Cells, Increases the Enrichment of High-Affinity Normally Augmented in Centrocytes Impairs Transgenic Overexpression of G5PR That Is

To investigate signals that control B cell selection, we examined expression of G5PR, a regulatory subunit of the serine/threonine protein phosphatase 2A, which suppresses JNK phosphorylation. G5PR is upregulated in activated B cells, in Ki67-negative centrocytes at germinal centers (GCs), and in puriﬁed B220 + Fas + GL7 + mature GC B cells following Ag immunization. G5PR rescues transformed B cells from BCR-mediated activation-induced cell death by suppression of late-phase JNK activation. In G5PR-transgenic (G5PR Tg ) mice, G5PR overexpression leads to an augmented generation of GC B cells via an increase in non-Ag– speciﬁc B cells and a consequent reduction in the proportion of Ag-speciﬁc B cells and high-afﬁnity Ab production after immunization with nitrophenyl-conjugated chicken g -globulin. G5PR overexpression impaired the afﬁnity–maturation of Ag-speciﬁc B cells, presumably by diluting the numbers of high-afﬁnity B cells. However, aged nonimmunized female G5PR Tg mice showed an increase in the numbers of peritoneal B-1a cells and the generation of autoantibodies. G5PR overexpression did not affect the proliferation of B-1a and B-2 cells but rescued B-1a cells from activation-induced cell death in vitro. G5PR might play a pivotal role in B cell selection not only for B-2 cells the of of sera from wild-type (WT) mice. The relative afﬁnity of the anti-NP Ab was estimated by calculating the ratio of the ELISA measurements as anti-NP 2 /anti-NP 25 . Immunoﬂuorescence analysis for anti-nuclear Abs Anti-nuclear was detected using an ANA-HEp-2 Immunoﬂuorescence Kit (ORGENTEC according to the manufacturer’s protocol. Brieﬂy, 80-fold diluted sera were reacted with HEp2 cells on the slide for 30 min at room temperature. After washing with PBS, Ag–Ab complex was detected with Alexa 488-conjugated anti-mouse IgG Ab. The signal was observed using a ﬂuorescence microscope BZ-8000.
Enhanced fault-tolerant Network-on-Chip architecture using hierarchical agents

The reliability is a vital aspect in the design of Network-on-Chip (NoC) based systems because a fault in communication medium may cause an overall system failure. On the other hand, performance degradation is an inescapable consequence of fault-tolerant architectures. In this paper, we propose a fault-tolerant NoC architecture that attains higher performance by using low cost agents in a hierarchical manner. These agents which are distributed all over the network, collect, process, and distribute different fault information. Moreover, we propose an enhanced fault-tolerant and congestion-aware routing method that exploits the classified fault information related to the permanent faults that might occur inside the links, network interfaces and different parts of the routers. The experimental results reveal that the proposed NoC architecture imposes small area and power overheads.
Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging

Background and Purpose— Brain edema is a life-threatening consequence of stroke and leads to an extension of the affected tissue. The space-occupying effect due to brain edema can be quantified in rat stroke models with the use of MRI. The present study was performed to test 2 hypotheses: (1) Can quantification of the space-occupying effect due to brain edema serve as a noninvasive measure for brain water content? (2) Does morphometric assessment of brain swelling allow determination of true infarct size on MRI after correction for the space-occupying effect of edema? Methods— Thirty rats were subjected to permanent suture middle cerebral artery occlusion. MRI was performed after 6 or 24 hours, and hemispheric swelling was assessed morphometrically. Interobserver and intraobserver agreements were determined for MRI measurements. In study I, the space-occupying effect due to brain edema was correlated with the absolute brain water content by the wet/dry method. In study II, lesion volumes corrected and uncorrected for edema were calculated on MRI and on TTC staining and compared. Results— Interobserver and intraobserver agreements for MRI measurements were excellent (r ≥0.97). Brain water content and hemispheric swelling correlated well after 6 and 24 hours (r ≥0.95). Corrected lesion volumes correlated with r =0.78 between TTC staining and MRI. Without edema correction, lesion volumes were overestimated by 20.3% after 6 hours and by 29.6% after 24 hours of ischemia. Conclusions— Morphometric assessment of hemispheric swelling on MRI can determine the increase in absolute brain water content noninvasively and can also provide ischemic lesion volumes corrected for brain edema.
The design and evaluation of prototype eco-feedback displays for fixture-level water usage data

Few means currently exist for home occupants to learn about their water consumption: e.g., where water use occurs, whether such use is excessive and what steps can be taken to conserve. Emerging water sensing systems, however, can provide detailed usage data at the level of individual water fixtures (i.e., disaggregated usage data). In this paper, we perform formative evaluations of two sets of novel eco-feedback displays that take advantage of this disaggregated data. The first display set isolates and examines specific elements of an eco-feedback design space such as data and time granularity. Displays in the second set act as design probes to elicit reactions about competition, privacy, and integration into domestic space. The displays were evaluated via an online survey of 651 North American respondents and in-home, semi-structured interviews with 10 families (20 adults). Our findings are relevant not only to the design of future water eco-feedback systems but also for other types of consumption (e.g., electricity and gas).
EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer

Histone modifications are thought to control the regulation of genetic programs in normal physiology and cancer. Methylation (mono-, di-, and tri-methylation) on histone H3 lysine (K) 27 induces transcriptional repression, and thereby participates in controlling gene expression patterns. Enhancer of zeste (EZH) 2, a methyltransferase and component of the polycomb repressive complex 2 (PRC2), plays an essential role in the epigenetic maintenance of the H3K27me3 repressive chromatin mark. Abnormal EZH2 expression has been associated with various cancers including breast cancer. Here, we discuss the contribution of EZH2 and the PRC2 complex in controlling the H3K27 methylation status and subsequent consequences on genomic instability and the cell cycle in breast cancer cells. We also discuss distinct molecular mechanisms used by EZH2 to suppress BRCA1 functions.
Short QT Syndrome

Short QT syndrome (SQTS) is an inheritable primary electrical disease of the heart, discovered in 1999. It is characterized by an abnormally short QT interval (<300 ms) and a propensity to atrial fibrillation and sudden cardiac death (SCD). Like in the case of long QT syndrome there is more than one genetic mutation that can lead to a short QT interval in the ECG and so far two have been identified. Shortening of the effective refractory period combined with increased dispersion of repolarization is the likely substrate for reentry and life threatening tachyarrhythmias. Only 22 people have been classified as having SQTS: 15 from the actual measurement of a short QT interval in their ECG and 7 by history, all having died from SCD. It is very likely that several cases, especially among children, have been overlooked, since the shortness of the QT interval only becomes apparent at heart rates <80 beats/min. The best form of treatment is still not known, but prevention of atrial fibrillation has been accomplished by propafenone, and an implantable cardioverter defibrillator is recommended for prevention of SCD.
The shoulder pain and disability index: the construct validity and responsiveness of a region-specific disability measure.

BACKGROUND AND PURPOSE The purposes of this study were (1) to assess the construct validity of the Shoulder Pain and Disability Index (SPADI) and (2) to determine whether the SPADI is more responsive than the Sickness Impact Profile (SIP), a generic health status measure. SUBJECTS The sample consisted of 94 patients who were diagnosed with a shoulder problem and referred to six outpatient physical therapy clinics. METHODS Clinically meaningful change was determined by use of an ordinal rating scale designed to determine whether the patient's shoulder function was improved, the same, or worse following treatment. Spearman rho correlations were calculated for the initial visit SPADI and SIP scores. The standardized response mean (SRM) was used to measure responsiveness for the patients who were judged to be improved. One-tailed paired t tests (alpha = .01) were used to determine whether differences existed among SRM values. RESULTS Correlations between the SPADI and SIP scores ranged from r = . 01 to r = . 57. The SRM value was higher for the SPADI total score (SRM = 1.38) than for the SIP total score (SRM = 0.79). CONCLUSION AND DISCUSSION Most correlations between SPADI and SIP scores provided support for the construct validity of the SPADI. The SPADI does not appear to strongly reflect occupational and recreational disability and is more responsive than the SIP.
Is a Map More Than a Picture? The Role of SDCC Technology, Subject Characteristics, and Problem Complexity of Reading and Problem Solving

This research investigated how the use of a spatial decision support system (SDSS)—a type of geographic information system (GIS)—influenced the accuracy and efficiency of different types of problem solvers (i.e. professionals versus students) completing problems of varied complexity. This research—the first to simultaneously study these variables—examined subjects who completed a problem involving spatiallyreferenced information The experiment was guided by a research model synthesized from various perspectives, including the theory of cognitive fit. prior research on map reading and interpretation, and research examining subject expertise and experience. The results are largely supportive of the research model and demonstrate that SDSS. an increasingly important class of management decision-making technology, increased the efficiency of users working on more complex problems. Professionals were found to be more accurate but less efficient than students: however. professionals who used the SDSS were no more accurate than professionals using paper maps. Need for cognition, a construct that focuses on an individual's willingness lo engage in problem solving tasks, was found to be marginally related to accuracy. The implications of these findings for researchers and practitioners are presented and discussed.
Caregiver Burden in Patients Receiving Ranibizumab Therapy for Neovascular Age Related Macular Degeneration

Purpose To assess the caregiver burden and factors determining the burden in patients receiving ranibizumab therapy for neovascular AMD (nAMD). Methods This is a cross-sectional questionnaire survey of 250 matched patient caregiver dyads across three large ophthalmic treatment centres in United Kingdom. The primary outcome was the subjective caregiver burden measured using caregiver reaction assessment scale (CRA). Objective caregiver burden was determined by the caregiver tasks and level of care provided. The factors that may predict the caregiver burden such as the patient’s visual acuity of the better eye and vision related quality of life, demographics, satisfaction and support provided by the healthcare and the health status of the dyads were also collected and assessed in a hierarchical regression model. Results The mean CRA score was 3.2±0.5, similar to the score reported by caregivers for atrial fibrillation who require regular hospital appointments for monitoring their thromboprophylaxis. Caregiver tasks including accompanying for hospital appointments for eye treatment and patient’s visual acuity in the better eye were the biggest contributors to the caregiver burden hierarchical model explaining 18% and 11% of the variance respectively. Conclusion Ranibizumab therapy for nAMD is associated with significant caregiver burden. Both disease impact and treatment frequency contributed to the overall burden.
Microstructural aspects of spallation in copper

Compressive shock waves result in a specific kind of fracture called a spall. The metallurgical aspects of copper spalling and crack or void initiation sites, the effects of grain size and substructure, and the micromechanical aspects of growth and coalescence have not received the detailed attention that other deformation phenomena have received. The present work was stimulated by the observation that under identical shock loading conditions the spall strength of copper can vary between 0.4 to 2.4 GPa - an unusually wide range - merely as a result of changes in its microstructure. Examples of fracture morphology are presented and possible micromechanics of fracture resulting from different microstructures are discussed. Finally, the implications of these observations on modeling are presented.
Pet Face: Mechanisms Underlying Human-Animal Relationships

Accumulating behavioral and neurophysiological studies support the idea of infantile (cute) faces as highly biologically relevant stimuli rapidly and unconsciously capturing attention and eliciting positive/affectionate behaviors, including willingness to care. It has been hypothesized that the presence of infantile physical and behavioral features in companion (or pet) animals (i.e., dogs and cats) might form the basis of our attraction to these species. Preliminary evidence has indeed shown that the human attentional bias toward the baby schema may extend to animal facial configurations. In this review, the role of facial cues, specifically of infantile traits and facial signals (i.e., eyes gaze) as emotional and communicative signals is highlighted and discussed as regulating the human-animal bond, similarly to what can be observed in the adult-infant interaction context. Particular emphasis is given to the neuroendocrine regulation of the social bond between humans and animals through oxytocin secretion. Instead of considering companion animals as mere baby substitutes for their owners, in this review we highlight the central role of cats and dogs in human lives. Specifically, we consider the ability of companion animals to bond with humans as fulfilling the need for attention and emotional intimacy, thus serving similar psychological and adaptive functions as human-human friendships. In this context, facial cuteness is viewed not just as a releaser of care/parental behavior, but, more in general, as a trait motivating social engagement. To conclude, the impact of this information for applied disciplines is briefly described, particularly in consideration of the increasing evidence of the beneficial effects of contacts with animals for human health and wellbeing.
Licking-Induced Synchrony in the Taste–Reward Circuit Improves Cue Discrimination during Learning

Animals learn which foods to ingest and which to avoid. Despite many studies, the electrophysiological correlates underlying this behavior at the gustatory–reward circuit level remain poorly understood. For this reason, we measured the simultaneous electrical activity of neuronal ensembles in the orbitofrontal cortex, insular cortex, amygdala, and nucleus accumbens while rats licked for taste cues and learned to perform a taste discrimination go/no-go task. This study revealed that rhythmic licking entrains the activity in all these brain regions, suggesting that the animal's licking acts as an “internal clock signal” against which single spikes can be synchronized. That is, as animals learned a go/no-go task, there were increases in the number of licking coherent neurons as well as synchronous spiking between neuron pairs from different brain regions. Moreover, a subpopulation of gustatory cue-selective neurons that fired in synchrony with licking exhibited a greater ability to discriminate among tastants than nonsynchronized neurons. This effect was seen in all four recorded areas and increased markedly after learning, particularly after the cue was delivered and before the animals made a movement to obtain an appetitive or aversive tastant. Overall, these results show that, throughout a large segment of the taste–reward circuit, appetitive and aversive associative learning improves spike-timing precision, suggesting that proficiency in solving a taste discrimination go/no-go task requires licking-induced neural ensemble synchronous activity.
Good Prognosis for Pericarditis With and Without Myocardial Involvement: Results From a Multicenter, Prospective Cohort Study

Background— The natural history of myopericarditis/perimyocarditis is poorly known, and recently published studies have presented contrasting data on their outcomes. The aim of the present article is to assess the prognosis of myopericarditis/perimyocarditis in a multicenter, prospective cohort study. Methods and Results— A total of 486 patients (median age, 39 years; range, 18–83 years; 300 men) with acute pericarditis or a myopericardial inflammatory syndrome (myopericarditis/perimyocarditis; 85% idiopathic, 11% connective tissue disease or inflammatory bowel disease, 5% infective) were prospectively evaluated from January 2007 to December 2011. The diagnosis of acute pericarditis was based on the presence of 2 of 4 clinical criteria (chest pain, pericardial rubs, widespread ST-segment elevation or PR depression, and new or worsening pericardial effusion). Myopericardial inflammatory involvement was suspected with atypical ECG changes for pericarditis, arrhythmias, and cardiac troponin elevation or new or worsening ventricular dysfunction on echocardiography and confirmed by cardiac magnetic resonance. After a median follow-up of 36 months, normalization of left ventricular function was achieved in >90% of patients with myopericarditis/perimyocarditis. No deaths were recorded, as well as evolution to heart failure or symptomatic left ventricular dysfunction. Recurrences (mainly as recurrent pericarditis) were the most common complication during follow-up and were recorded more frequently in patients with acute pericarditis (32%) than in those with myopericarditis (11%) or perimyocarditis (12%; P<0.001). Troponin elevation was not associated with an increase in complications. Conclusions— The outcome of myopericardial inflammatory syndromes is good. Unlike acute coronary syndromes, troponin elevation is not a negative prognostic marker in this setting.
Candidacidal activity of mouse macrophages in vitro

Mouse peritoneal macrophages were infected in vitro with Candida albicans, and the phagocytic and candidacidal activities were estimated by microscopic examination of Giemsa-stained cells. Activated macrophages obtained from either BCG-vaccinated animals or by in vitro exposure of normal macrophages to phytohemagglutinin-induced lymphokines exhibited higher phagocytic and candidacidal activities than did normal macrophages. However, activated macrophages obtained by in vitro exposure of macrophages to candida-induced lymphokines exhibited the highest phagocytic and candidacidal activities. The incorporation of immune mouse serum into the culture medium also enhanced the phagocytic and candidacidal activities of the normal macrophages but failed to improve the function of the activated macrophages. These results suggest that both activated macrophages and antibodies may be required for controlling candida infections in mice.
A control Lyapunov function approach to multi-agent coordination

In this paper, the multiagent coordination problem is studied. This problem is addressed for a class of robots for which control Lyapunov functions can be found. The main result is a suite of theorems about formation maintenance, task completion time, and formation velocity. It is also shown how to moderate the requirement that, for each individual robot, there exists a control Lyapunov function. An example is provided that illustrates the soundness of the method.
Modeling the color evolution of luminous red galaxies - improvements with empirical stellar spectra

Predicting the colors of Luminous Red Galaxies (LRGs) in the Sloan Digital Sky Survey (SDSS) has been a long-standing problem. The g,r,i colors of LRGs are inconsistent with stellar population models over the redshift range 0.1<z<0.7. The g-r colors in the models are on average redder than the data while the r-i colors in the models are bluer towards low redshift. Beyond redshift 0.4, the predicted r-i color becomes instead too red, while the predicted g-r agrees with the data. We provide a solution to this problem, through a combination of new astrophysics and a fundamental change to the stellar population modeling. We find that the use of the empirical library of Pickles (1998) instead of theoretical spectra modifies the predicted colors exactly in the way suggested by the data. The reason is a lower flux in the empirical libraries, with respect to the theoretical ones, in the wavelength range 5500-6500 AA. The discrepancy increases with decreasing effective temperature independently of gravity. This result has general implications for a variety of studies from globular clusters to high-redshift galaxies. The astrophysical part of our solution regards the composition of the stellar populations of these massive Luminous Red Galaxies. We find that on top of the previous effect one needs to consider a model in which ~3% of the stellar mass is in old metal-poor stars. Other solutions such as substantial blue Horizontal Branch at high metallicity or young stellar populations can be ruled out by the data. Our new model provides a better fit to the g-r and r-i colors of LRGs and gives new insight into the formation histories of these most massive galaxies. Our model will also improve the k- and evolutionary corrections for LRGs which are critical for fully exploiting present and future galaxy surveys.
Diabetes Mellitus and Cardiovascular Events in Older Patients With Myocardial Infarction Prescribed Intensive-Dose and Moderate-Dose Statins

Background— Practice guidelines recommend intensive-dose statins for patients with acute coronary syndrome, but recent data about the risk of new-onset diabetes mellitus have raised concerns about its use. Our main objective was to evaluate the association between intensive statin therapy and new-onset diabetes mellitus in patients with myocardial infarction and to evaluate the association of intensive statin therapy with long-term adverse clinical outcomes. Methods and Results— A propensity score–matched cohort was created consisting of 17 080 patients with myocardial infarction aged >65 years old, hospitalized in Ontario, Canada, from 2004 to 2010. Clinical outcomes were compared in patients prescribed intensive-dose versus moderate-dose statins at hospital discharge. At 5 years, 13.6% of patients receiving intensive-dose statins and 13.0% of patients receiving moderate-dose statins had new-onset diabetes, which was not significantly different (P=0.19). By contrast, the 5-year rate of death or acute coronary syndrome was significantly lower at 44.8% in the intensive-dose statin group compared with 46.5% in the moderate-dose group (P=0.044). The reduction in combined clinical outcome was driven mainly by a significantly lower rate of acute coronary syndrome (P=0.039) associated with intensive-dose statins. No significant difference in mortality rates (34.8% in both groups) was observed between the treatment groups during the study period (P=0.89). Conclusions— In older patients with myocardial infarction, we found intensive-dose statin therapy to be effective in reducing repeat hospitalization for acute coronary syndrome. The rate of new-onset diabetes mellitus at long term was not significantly different between intensive-dose and moderate-dose statins.