Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Treatment of Temporomandibular Disorders (TMD) in Patients with Cervicogenic Headache: A Single-Blind, Randomized Controlled Study

Abstract The present study was comprised of 43 patients (16 men) with cervicogenic headaches for over three months, diagnosed according to the International Classification of Diagnostic Criteria of Headaches (ICDH-ll). The patients were randomly assigned to receive either manual therapy for the cervical region (usual care group) or additional manual therapy techniques to the temporomandibular region to additionally influence temporomandibular disorders (TMD). All patients were assessed prior to treatment, after six sessions of treatment, and at a six-month follow-up. The outcome criteria were: intensity of headaches measured on a colored analog scale, the Neck Disability Index (Dutch version), the Conti Anamnestic Questionnaire, noise registration at the mandibular joint using a stethoscope, the Graded Chronic Pain Status (Dutch version), mandibular deviation, range of mouth opening, and pressure/pain threshold of the masticatory muscles. The results indicate in the studied sample of cervicogenic headache patients, 44.1% had TMD. The group that received additional temporomandibular manual therapy techniques showed significantly decreased headache intensities and increased neck function after the treatment period. These improvements persisted during the treatment-free period (follow-up) and were not observed in the usual care group. This trend was also reflected on the questionnaires and the clinical temporomandibular signs. Based on these observations, we strongly believe that treatment of the temporomandibular region has beneficial effects for patients with cervicogenic headaches, even in the long-term.
Amblyopia: site unseen

The site of the amblyopic deficit has been keenly sought for the past half century. Controversy has raged concerning whether it is retinal or cortical. Neurophysiologists and clinicians have provided compelling evidence to support their respective cases. Its resolution in terms of a primary cortical deficit is relatively recent and provides an interesting insight into the working of science. Currently, another controversy is beginning concerning which cortical areas are affected in amblyopia. Only time will tell if this new debate proves as interesting as its retinal counterpart. This review concentrates on where the site of the amblyopic deficit resides. It intentionally bypasses the issue of the nature of the deficit, an issue worthy of a separate review.
Introduction to Special Section: Psychological Constructivism

In an attempt to better understand and integrate theories and research in the field of emotion, Emotion Review has dedicated several special sections to address core concepts and controversies in the field. Critical to this goal has been a series of issues examining the current status of the dominant perspectives on the nature of emotion. Special sections on basic emotion theory, appraisal theory, and social constructivism have already appeared, and this section continues this series by exploring psychological constructivism. Constructivist approaches suggest that psychological concepts (e.g., happiness) are created and do not reflect biological “natural kinds. ” Whereas social constructivist approaches propose that emotions arise from culture, social convention, and agreed-upon meaning (Averill, 1980), psychological constructivist approaches propose that emotions arise from the interaction of primitive psychological processes that may have a biological basis (Barrett, 2009; Russell, 2003). Although culture and convention matter for psychological constructivist approaches, the focus is on the core invariant psychological principles that shape our experience. Critically, emotions do not separate class from cognition, but rather emerge from the interaction of fundamental processes that are shared across psychological domains (Barrett, 2006; Cunningham & Brosch, 2012; Cunningham & Kirkland, 2012; Lindquist & Gendron, 2013; Lindquist, Wager, Kober, BlissMoreau, & Barrett, 2012; Russell, 2009; Widen, 2013). Because emotions are proposed to be emergent and not reducible to a single process, research from a psychological constructivist approach needs to articulate not only which ingredients are necessary/sufficient for emotion, but also how these ingredients combine and interact to give rise to new psychological states (Barrett, 2013). Further, the sets of processes that give rise to different emotions (i.e., either an episode of fear and an episode of anger; or two instances of fear) can rely on both shared and distinct processes. To examine these ingredients and their interactions, for each of the articles in this special section the authors were asked to discuss why psychological constructivism was a useful approach to understand emotion, and to provide details about how emotions emerged from core ingredients. Specifically, the authors were asked to address a series of questions:
Prospective validation of clinically important changes in pain severity measured on a visual analog scale.

BACKGROUND In a landmark hypothesis-generating study, Todd et al found that a difference of approximately 13 mm (95% confidence interval [CI] 10 to 17 mm) on a visual analog scale (VAS) represented the minimum change in acute pain that was clinically significant in a cohort of trauma patients. STUDY OBJECTIVE We test the hypothesis that the minimum clinically significant change in pain as measured by the VAS in an independent, more heterogeneous validation cohort is approximately 13 mm. METHODS This was a prospective, observational cohort study of adults presenting to 2 urban emergency departments with pain. At 30-minute intervals during a 2-hour period, patients marked a VAS and were asked if their pain was "much less," "a little less," "about the same," "a little more," or "much more. " All data were obtained without reference to prior VAS scores. The minimum clinically significant change in pain was defined a priori as the difference in millimeters between the current and immediately preceding VAS scores when "a little more" or "a little less pain" was reported. RESULTS Ninety-six patients enrolled in the study, providing 332 paired pain measurements. There were 141 paired measurements designated by patients as "a little less" or "a little more" pain. The mean clinically significant difference between consecutive ratings of pain in the combined "little less" or "little more" groups was 13 mm (95% CI 10 to 16 mm). The difference between this finding and that of Todd et al was 0 mm (95% CI -4 to 4 mm). CONCLUSION These data are virtually identical to previous findings indicating that a difference of 13 mm on a VAS represents, on average, the minimum change in acute pain that is clinically significant.
ASIRPA - Analyse des Impacts de la Recherche Publique Agronomique. Rapport final

Le rapport fait le bilan de trois annees de recherche concernant les methodologies d'evaluation d'un organisme public de recherche finalisee. Au cours de trois annees de recherche, l'equipe ASIRPA a construit une approche d'evaluation fondee sur la realisation d'etudes de cas standardisees, conciliant analyse qualitative et quantitative des impacts des recherches selon cinq dimensions d'analyse. La demarche a ete utilisee avec succes par les departements de recherche de l'institut. Une analyse transversale des 30 etudes realisees a ce jour a permis de construire une typologie de 5 familles de chemins d'impact caracteristiques de l'institut. Le present rapport demontre la pertinence des etudes ex post pour permettre a un organisme finalise de mieux connaitre l'impact de ses recherches, et favoriser les echanges avec les chercheurs et les partenaires autour de cette question
Does Media Cross-Ownership Translate into Cross-Promotion?

Recent waves of cross-media concentration, in Flanders (Belgium) and elsewhere, reinvigorate concerns regarding the impact of ownership structures on media content and the way in which it is produced, including discussions about editorial autonomy. However, with a main focus on hard news, this debate pays little attention to corporate influence on soft news issues, such as media's cross-promotion of affiliated media outlets. The current study wishes to address this shortcoming by means of a diachronic quantitative content analysis of Flemish newspapers' coverage of television programmes. The article analyses whether media cross-ownership results in cross-promotion of press outlets' affiliated television stations. Results partly support the thesis that newspapers cover their affiliated television stations more frequently. Yet the article also explores alternative explanations, such as characteristics of newspapers, of target audiences and of the television programmes obtaining coverage (including broadcast frequency and genre). Hence the article points to the complexity of tackling cross-promotion and the importance of taking alternative elements into account.
Manipulating the immune system for anti‐tumor responses and transplant tolerance via mixed hematopoietic chimerism

Summary: Stem cells (SCs) with varying potentiality have the capacity to repair injured tissues. While promising animal data have been obtained, allogeneic SCs and their progeny are subject to immune‐mediated rejection. Here, we review the potential of hematopoietic stem cells (HSCs) to promote immune tolerance to allogeneic and xenogeneic organs and tissues, to reverse autoimmunity, and to be used optimally to cure hematologic malignancies. We also review the mechanisms by which hematopoietic cell transplantation (HCT) can promote anti‐tumor responses and establish donor‐specific transplantation tolerance. We discuss the barriers to clinical translation of animal studies and describe some recent studies indicating how they can be overcome. The recent achievements of durable mixed chimerism across human leukocyte antigen barriers without graft‐versus‐host disease and of organ allograft tolerance through combined kidney and bone marrow transplantation suggest that the potential of this approach for use in the treatment of many human diseases may ultimately be realized.
Tumor Volume as a Potential Imaging-Based Risk-Stratification Factor in Trimodality Therapy for Locally Advanced Non-small Cell Lung Cancer

Introduction:The role of trimodality therapy for locally advanced non-small cell lung cancer (NSCLC) continues to be defined. We hypothesized that imaging parameters on pre- and postradiation positron emission tomography (PET)-computed tomography (CT) imaging are prognostic for outcome after preoperative chemoradiotherapy (CRT)/resection/consolidation chemotherapy and could help risk-stratify patients in clinical trials. Methods:We enrolled 13 patients on a prospective clinical trial of trimodality therapy for resectable locally advanced NSCLC. PET-CT was acquired for radiation planning and after 45 Gy. Gross tumor volume (GTV) and standardized uptake value were measured at pre- and post-CRT time points and correlated with nodal pathologic complete response, loco-regional and/or distant progression, and overall survival. In addition, we evaluated the performance of automatic deformable image registration (ADIR) software for volumetric response assessment. Results:All patients responded with average total GTV reductions after 45 Gy of 43% (range: 27–64%). Pre- and post-CRT GTVs were highly correlated (R2 = 0.9), and their respective median values divided the patients into the same two groups. ADIR measurements agreed closely with manually segmented post-CRT GTVs. Patients with GTV ≥ median (137 ml pre-CRT and 67 ml post-CRT) had 3-year progression-free survival (PFS) of 14% versus 75% for GTV less than median, a significant difference (p = 0.049). Pre- and post-CRT PET-standardized uptake value did not correlate significantly with pathologic complete response, PFS, or overall survival. Conclusions:Preoperative CRT with carboplatin/docetaxel/45 Gy resulted in excellent response rates. In this exploratory analysis, pre- and post-CRT GTV predicted PFS in trimodality therapy, consistent with our earlier studies in a broader cohort of NSCLC. ADIR seems robust enough for volumetric response assessment in clinical trials.
On the biasing Effect of a Battery on a Self-exciting Faraday Disk homopolar dynamo Loaded with a Linear Series Motor

We extend the study of Hide et al. [1996] for a self-exciting Faraday disk homopolar dynamo with a linear motor connected in series with the coil to cases when a battery is included in the circuit, using the set of nonlinear equations for biased systems given in [Hide, 1997]. The presence of the battery introduces asymmetry into the model, creating two distinct branches of equilibrium solutions, two distinct branches of oscillatory solutions and two different codimension-two bifurcations.
A randomised study on the effectiveness of therapist-led v. self-help parental intervention for treating childhood obesity

A strategy is needed on how to treat the growing number of obese children with the limited resources available. We compared the long-term (24 months) effectiveness of therapist-led groups (TLG) v. self-help groups (SHG) for parents on changes in children's adiposity and dietary intake. The study included ninety-nine children (forty-eight girls) who were referred to obesity treatment (7–12 years, BMI z-scores ≥ 2, attendance of at least one parent). Parents (ninety-one mothers, fifty-four fathers) were randomised to TLG aimed at increasing parents' competence to accomplish lifestyle changes (n 47), or SHG (n 52), both with fifteen sessions. All children participated in children's groups, and all families attended individual counselling by a clinical dietitian and physiotherapist. Percentage of body fat (BF) was measured by dual-energy X-ray absorptiometry, BMI z-score was calculated by international reference values and dietary intake was calculated from 4 d estimated food records at baseline and after 6 and 24 months. No significant between-group differences were detected in the children's changes in adiposity or dietary intake after 6 and 24 months. BF, BMI z-scores and energy intake were significantly decreased after 6 months (P< 0·05) in both intervention groups, and this persisted throughout 24 months without compromising the diet macronutrient composition. In conclusion, the TLG and SHG intervention groups appear to be equally effective in improving long-term adiposity and dietary intake in obese children. Further research should be performed to clarify whether the SHG should be preferred to parental group treatment for similar children with obesity.
Psychosocial Interventions and Therapeutic Support as a Standard of Care in Pediatric Oncology

Research indicates that a subset of youths with childhood cancer and their parents will experience significant psychological distress throughout the course of their illness. Importantly, the existing literature indicates that psychosocial support is beneficial in decreasing symptoms of distress in these families. The aim of the current review is to determine the extent of the evidence to support a standard of psychosocial care for children and their families throughout the cancer trajectory; thus, we examined the research related to psychosocial outcomes in youth with cancer and their parents. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Tracing the origin of Brazilian HTLV-1 as determined by analysis of host and viral genes

We compared the genetic diversity of the Brazilian human T-cell lymphotropic virus type 1 isolates with those found in KwaZulu–Natal (KZN), South Africa, and with the genetic background of the hosts. The seroprevalence rate in KZN was 1.7%. All sequences belonged to the A subgroup. The presence of South African sequences in two different clusters from Brazil, and the finding of the βA-globin haplotype in infected hosts are consistent with the transmission of this virus from southern Africa to Brazil.
PENGARUH KEPEMIMPINAN TRANSFORMASIONAL TERHADAP KEPUASAN KERJA KARYAWAN

Active role of leader and model of leadership fit company needs are extremely necessary. Employees have a desire to be led by a certain person who have vision of explicit goals, understanding how to realize the goals and try to teach them. The role of leader in a corporate is anticipated to create fair sense of employees; characteristics of leader have effects on the working climate in a corporate. Leader anticipated by corporate employees is one with capability to give employees with job satisfaction. The study was designed to examine whether transformational leadership have significant effect on the working job satisfaction. Using sample of PT. Pos Indonesia (Company) Sumedang Subsidiary employees, the data was collected by means of distribution of 64 questionnaires. Based on the simple linear regression analysis used, the findings suggest the transformational leadership have significantly positive effect on the employees’ job satisfaction. Keywords: Transformational Leadership, Job Satisfaction Abstrak Peran aktif pemimpin dan model kepemimpinan yang sesuai dengan kebutuhan perusahaan merupakan hal penting. Karyawan mengharapkan dapat dipimpin oleh seorang pemimpin yang memiliki visi dengan tujuan yang jelas, memahami bagaimana untuk merealisasikan tujuan dan mampu mengarahkannya. Peran pemimpin dalam perusahaan diharapkan dapat menciptakan perasaan memiliki bagi karyawan, pemimpin yang memiliki karakter, akan mampu memberikan pengaruh terhadap iklim kerja dalam perusahaan. penelitian ini dirancang untuk menguji apakah kepemimpinan transformasional memiliki pengaruh terhadap kepuasan kerja. Sampel yang digunakan adalah karyawan PT POS Indonesia cabang Sumedang, sebanyak 64 orang. data yang diperlukan dikumpulkan dengan kuesioner. Metode analisis data yang digunakan adalah regresi linear. Hasilnya menunjukkan bahwa kepemimpinan transformasional berpengaruh positif terhadap kepuasan kerja karyawan. Kata kunci: kepemimpinan transformasional, kepuasan kerja
Evaluation of the Effect of Four Fibers on Laxation, Gastrointestinal Tolerance and Serum Markers in Healthy Humans

Background: Average dietary fiber intake in the United States is roughly half of the recommended amount. As new dietary fiber products are introduced to increase fiber intake, it is critical to evaluate the physiological effects of such fibers. Aims: This study examined the effect of 4 fibers derived from maize or tapioca on fecal chemistry, gastrointestinal (GI) symptoms and serum markers of chronic disease. Methods: Twenty healthy subjects completed the single-blind crossover study in which 12 g/day of fiber (pullulan, Promitor™ Resistant Starch, soluble fiber dextrin or Promitor Soluble Corn Fiber) or placebo (maltodextrin) were consumed for 14 days followed by a 21-day washout. GI symptom surveys were completed (days 3 and 14), stools were collected (days 11–14), diet was recorded (days 12–14) and fasting blood samples were obtained (day 15). Results: The 4 test fibers were well tolerated, with mild to moderate GI symptoms. Total short-chain fatty acid (SCFA) concentrations did not differ among the treatments. Fecal pH and individual SCFAs were affected by some treatments. Stool weight and serum markers of chronic disease did not change with these treatments. Conclusion: Increasing fiber intake by 12 g/day was well tolerated and may have a positive impact on colon health due to fermentation.
T Lymphocytes in the Liver + CD8Functional Suppression of Virus-Specific PD-1:PD-L1 Interactions Contribute to the

2 * Mechanisms contributing to the development of chronic viral infections, including chronic hepatitis B virus (HBV) infections, are not well understood. We have shown recently that production of IFN- (cid:2) , an important antiviral cytokine, by HBV-speciﬁc CTLs is rapidly induced when they enter the liver of HBV transgenic mice, and then rapidly suppressed, despite the continued presence of Ag. Suppression of IFN- (cid:2) production by the CTLs coincides with the up-regulation of programmed cell death (PD)-1, a cell surface signaling molecule known to inhibit T cell function. To determine whether PD-1 plays a role in the functional suppression of IFN- (cid:2) secretion by CTLs, we treated HBV transgenic mice with blocking Abs speciﬁc for PD ligand (PD-L)1, the most widely expressed PD-1 ligand, and adoptively transferred HBV-speciﬁc CTLs. Treatment with anti-PD-L1 Abs resulted in a delay in the suppression of IFN- (cid:2) -producing CTLs and a concomitant increase in the absolute number of IFN- (cid:2) -producing CTLs in the liver. These results indicate that PD-1:PD-L1 interactions contribute to the suppression of IFN- (cid:2) secretion observed following Ag recognition in the liver. Blockade of inhibitory pathways such as PD-1:PD-L1 may reverse viral persistence and chronic infection in cases in which the CTL response is suppressed by this mechanism. The Journal of Immunology, 2007, 178: 2714–2720. Calbiochem), and epidermal growth factor (55 ng/ml; Calbiochem), and di-luted 2-fold in hepatocyte culture medium, then added directly to the HBV- Met cells. In some experiments, isotype control, anti-IFN- (cid:1) , or anti-TNF- (cid:2) neutralizing Abs (4) were added to the peptide-stimulated supernatant 30 min before addition to MMDH3 cells. Twenty-four hours later, cells were harvested by trypsinization, washed, and used for ﬂow cytometry.
Understanding and Challenging Populist Negativity towards Politics: The Perspectives of British Citizens

This article adapts and develops the idea of a cynical or ‘stealth’ understanding of politics to explore how citizens’ estrangement from formal politics is processed cognitively through a populist lens. Earlier work has shown the widespread presence of stealth attitudes in the United States and Finland. We show that stealth attitudes are also well established in Britain, demonstrate their populist character and reveal that age, newspaper readership and concerns about governing practices help predict their adoption by individuals. Yet our survey findings also reveal a larger body of positive attitudes towards the practice of democracy suggesting that there is scope for challenging populist cynicism. We explore these so-called ‘sunshine’ attitudes and connect them to the reform options favoured by British citizens. If we are to challenge populist negativity towards politics, we conclude that improving the operation of representative politics is more important than offering citizens new forms of more deliberative participation.