Miracle-dz/UniFAR-FTUs huggingface dataset:
High Levels of Nuclear MYC Protein Predict the Presence of MYC Rearrangement in Diffuse Large B-cell Lymphoma

Determining the presence of MYC gene rearrangements is becoming an increasingly important part of the diagnostic workup in aggressive lymphoma. Cytogenetic MYC alterations aid in differentiating diffuse large B-cell lymphoma (DLBCL) from Burkitt lymphoma. In addition, MYC aberrations are associated with poor prognosis in DLBCL. Fluorescence in situ hybridization and karyotyping are standard tests for detecting MYC aberrations, but these techniques are laborious and expensive. Here, we studied MYC status of 219 DLBCLs and Burkitt lymphomas using fluorescence in situ hybridization, immunohistochemistry, and quantitative real-time polymerase chain reaction (QRT-PCR). Overall, 15% of the cases had an MYC break. QRT-PCR analysis of MYC expression showed that 72% of DLBCLs with an MYC break had aberrantly high or low levels of MYC transcript. Excluding the cases with aberrantly low MYC expression, we found a significant positive correlation between levels of MYC transcripts and MYC+ tumor cells; however, QRT-PCR is not readily applicable as a screening tool. Immunohistochemically, all tumors showed a nuclear staining pattern that was simple to evaluate. The percentage of MYC+ lymphoma cells correlated closely with MYC rearrangement status. In all, 93% of cases with an MYC break had ≥80% MYC+ cells, in contrast to 3% of nonrearranged cases (P<0.0001). Receiver operating characteristic curve analysis showed ≥70% MYC+ tumor cells to be the optimal cutoff (sensitivity=100%, specificity=93%). Area under the receiver operating characteristic curve was 0.992, indicating that immunostaining for Myc protein is an excellent screening test to predict whether an MYC rearrangement is present.
Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo

Cyclic nucleotides are critical regulators of synaptic plasticity and participate in requisite signaling cascades implicated across multiple neurotransmitter systems. Phosphodiesterase 9A (PDE9A) is a high-affinity, cGMP-specific enzyme widely expressed in the rodent central nervous system. In the current study, we observed neuronal staining with antibodies raised against PDE9A protein in human cortex, cerebellum, and subiculum. We have also developed several potent, selective, and brain-penetrant PDE9A inhibitors and used them to probe the function of PDE9A in vivo. Administration of these compounds to animals led to dose-dependent accumulation of cGMP in brain tissue and cerebrospinal fluid, producing a range of biological effects that implied functional significance for PDE9A-regulated cGMP in dopaminergic, cholinergic, and serotonergic neurotransmission and were consistent with the widespread distribution of PDE9A. In vivo effects of PDE9A inhibition included reversal of the respective disruptions of working memory by ketamine, episodic and spatial memory by scopolamine, and auditory gating by amphetamine, as well as potentiation of risperidone-induced improvements in sensorimotor gating and reversal of the stereotypic scratching response to the hallucinogenic 5-hydroxytryptamine 2A agonist mescaline. The results suggested a role for PDE9A in the regulation of monoaminergic circuitry associated with sensory processing and memory. Thus, PDE9A activity regulates neuronal cGMP signaling downstream of multiple neurotransmitter systems, and inhibition of PDE9A may provide therapeutic benefits in psychiatric and neurodegenerative diseases promoted by the dysfunction of these diverse neurotransmitter systems.
Pengaruh Event Sponsorship Terhadap Brand Image Rokok A – Mild Pada PT. HM SAMPOERNA TBK. CABANG PEKANBARU

Penelitian ini dilakukan pada PT HM Sampoerna Tbk. Cabang Pekanbaru Tujuan dari penelitian iniadalah untuk menganalisis pengaruh yang ditimbulkan oleh variabel event sponsorship terhadapbrand image rokok A-Mild pada PT HM Sampoerna Tbk. Cabang Pekanbaru. Untuk mencapai tujuantersebut, dilakukan penelitian dengan menggunakan sampel sebanyak 100 orang responden. Metodepengambilan sampel dilakukan secara Accidental Sampling, dimana sampel yang dijadikan respondenpada penelitian ini adalah konsumen rokok A-Mild yang ditemui secara kebetulan pada saat penelitianini berlangsung.Metode analisis yang digunakan pada penelitian ini adalah metode deskriptif kuantitatif dan analisissecara parsial (analisis regresi linear sederhana dengan bantuan program SPSS versi 17.0). Namun,sebelum analisis tersebut dilakukan, jawaban responden per variabel ditransformasikan terlebihdahulu menjadi jawaban yang berskala interval dengan menggunakan Metode Suksesif Interval (MSI)dengan bantuan program ORDI versi 1.0. untuk mendapatkan gambaran jawaban responden yanglebih tajam dan akurat. Dari hasil pengujian yang telah dilakukan, uji regresi parsial (Uji t)menunjukkan bahwa variabel bebas yang diteliti memiliki pengaruh yang signifikan terhadap variabelbrand image.
Bled eConference eIntegration in Action Bled , Slovenia , June 6-8 , 2005 Comparing two Business Model Ontologies for Designing e-Business Models and Value Constellations

Business models have been an important topic in various disciplines and particularly e-business. Yet, little research has tempted to compare and integrate the different business model approaches. This paper compares two business model ontologies, the Business Model Ontology BMO and the evalue ontology, for the design of business models and value constellations. For that purpose it introduces a framework that allows the comparison of different conceptual approaches to business models. The two ontologies are illustrated through a case study in the domain of rights music management. The outcome of the analysis is twofold. Firstly, it permits a better understanding of business model research. Secondly, it highlights the possible paths to integrate the two ontologies in order to improve the representation, design, and analysis of business models.
Sleeping brain, learning brain. The role of sleep for memory systems

The hypothesis that sleep participates in the consolidation of recent memory traces has been investigated using four main paradigms: (1) effects of post-training sleep deprivation on memory consolidation, (2) effects of learning on post-training sleep, (3) effects of within sleep stimulation on the sleep pattern and on overnight memories, and (4) re-expression of behavior-specific neural patterns during post-training sleep. These studies convincingly support the idea that sleep is deeply involved in memory functions in humans and animals. However, the available data still remain too scarce to confirm or reject unequivocally the recently upheld hypothesis that consolidations of non-declarative and declarative memories are respectively dependent upon REM and NREM sleep processes.
Modeling denial‐of‐service against pending interest table in named data networking

Named data networking (NDN) has attracted much attention on the design for next generation Internet architecture. Although it embeds some security primitives in its original architecture, it may suffer from denial‐of‐service (DoS) attacks. In this paper, we model one representative type of NDN‐specific DoS attacks named DoS against pending interest table (PIT), or DoS‐PIT, which floods malicious Interests that request nonexistent content to bypass cached content at routers and to exhaust the memory resource for PIT, bringing in severe service degradation. In our proposed analytical model, the closed‐form expressions for the DoS probability for users suffering DoS‐PIT are derived, while considering several important factors of NDN networks such as PIT size, time‐to‐live of each PIT entry, popularity of content, and cache size. Moreover, extensive simulation experiments demonstrate the accuracy of the proposed model on evaluating the damage effect of DoS‐PIT. In addition, the proposed model can be chosen to guide designing effective countermeasures for DoS‐PIT (or attacks with similar way to harm NDN) by properly setting the values of some parameters (e.g., cache size) of each NDN router. Copyright © 2013 John Wiley & Sons, Ltd.
Health services use and health care costs of obese and nonobese individuals.

BACKGROUND Obesity has clinical and economic consequences. Few studies have compared health care resource utilization between age- and sex-matched obese and nonobese persons. METHODS We conducted a retrospective study in obese and nonobese individuals matched by age, sex, medical clinic, and selected exclusionary diagnoses. Data collected included hospitalizations, outpatient visits, professional claims, and prescriptions over 1 year. Costs were assigned to medical resources based on market prices using publicly available costs. Comorbid conditions were determined using a chronic disease score (CDS) index. Groups were compared on types and costs of resources consumed. Regression models were used to examine the effect of body mass index (BMI) on costs while controlling for age and chronic diseases. RESULTS A total of 539 obese and 1225 nonobese persons were examined. Obese patients had more hospitalizations (P<.001), prescription drugs (P<.001), professional claims (P<.001), and outpatient visits (P = .005). Obese patients used more cardiovascular, intranasal allergic rhinitis, asthma, ulcer, diabetes, thyroid, and analgesic drugs. Total costs between groups were different (median of $585.44 for obese and $333.24 for nonobese patients; P<.001). Cost differences were primarily due to medications (P<.001). Predictors of total costs were age, sex, BMI, and CDS. For each unit BMI increase, costs increased 2.3% (P<.001). For each CDS unit increase, costs increased 52.9% (P<.001). CONCLUSION Over 1 year, health care costs for obese persons are higher than for nonobese persons, primarily because of prescription drugs.
Simulator for Minimally Invasive Vascular Interventions: Hardware and Software

In the present work, a simulation system is proposed that can be used as an educational tool by physicians in training basic skills of minimally invasive vascular interventions. In order to accomplish this objective, initially the physical model of the wire proposed by Konings has been improved. As a result, a simpler and more stable method was obtained to calculate the equilibrium configuration of the wire. In addition, a geometrical method is developed to perform relaxations. It is particularly useful when the wire is hindered in the physical method because of the boundary conditions. Then a recipe is given to merge the physical and the geometrical methods, resulting in efficient relaxations. Moreover, tests have shown that the shape of the virtual wire agrees with the experiment. The proposed algorithm allows real-time executions, and furthermore, the hardware to assemble the simulator has a low cost.
An empirical study on behavioural intention to reuse e-learning systems in rural China

The learner’s acceptance of e-learning systems has received extensive attention in prior studies, but how their experience of using e-learning systems impacts on their behavioural intention to reuse those systems has attracted limited research. As the applications of e-learning are still gaining momentum in developing countries, such as China, it is necessary to examine the relationships between e-learners’ experience and perceptions and their behavioural intention to reuse, because it is argued that system reuse is an important indicator of the system’s success. Therefore, a better understanding of the multiple factors affecting the e-learner’s intention to reuse could help e-learning system researchers and providers to develop more effective and acceptable e-learning systems. Underpinned by the information system success model, technology acceptance model and self-efficacy theory, a theoretical framework was developed to investigate the learner’s behavioural intention to reuse e-learning systems. A total of 280 e-learners were surveyed to validate the measurements and proposed research model. The results demonstrated that e-learning service quality, course quality, perceived usefulness, perceived ease of use and self-efficacy had direct effects on users’ behavioural intention to reuse. System functionality and system response have an indirect effect, but system interactivity had no significant effect. Furthermore, self-efficacy affected perceived ease of use that positively influenced perceived usefulness.
Rheumatic disorders and primary biliary cirrhosis: an appraisal of 170 Italian patients

OBJECTIVE To establish the frequency of connective tissue diseases (CTD) in a cohort of Italian patients with primary biliary cirrhosis (PBC) and to evaluate the availability of a marker for the early identification of the more common associated CTD. METHODS One hundred and seventy consecutive patients with histologically diagnosed PBC were screened for the presence of a CTD and/or Raynaud's phenomenon (RP). Patients were classified as having a CTD only if they fulfilled standardised criteria. RESULTS Forty seven patients had a CTD. The most common CTD was systemic sclerosis (SSc), found in 21 patients. RP was present in 54 patients, most of whom (n=39) had an associated CTD. The most prevalent autoantibodies included antinuclear antibodies (ANA) with anticentromere (ACA) and speckled patterns (34 and 33 patients, respectively) and extractable nuclear antigens (ENA, 27 patients). However, while the frequencies of ACA and ENA were significantly higher in patients with an associated CTD (p<0.0001 and p<0.005, respectively), no relationship was found for speckled ANA. ACA was the best predictor of a CTD in patients with PBC (odds ratio (OR) 24.5, 95% CI 5.5 to 108.8), followed by the presence of ENA (OR 23.9, 95% CI 5.6 to 101.0) and RP (OR 20.2, 95% CI 5.7 to 71.2). CONCLUSIONS Using strict standardised classification criteria we have found that SSc is the most common CTD associated with PBC and that ACA and ENA are strong markers for an associated CTD in patients with PBC.
Spiral in scala: towards the systematic construction of generators for performance libraries

Program generators for high performance libraries are an appealing solution to the recurring problem of porting and optimizing code with every new processor generation, but only few such generators exist to date. This is due to not only the difficulty of the design, but also of the actual implementation, which often results in an ad-hoc collection of standalone programs and scripts that are hard to extend, maintain, or reuse. In this paper we ask whether and which programming language concepts and features are needed to enable a more systematic construction of such generators. The systematic approach we advocate extrapolates from existing generators: a) describing the problem and algorithmic knowledge using one, or several, domain-specific languages (DSLs), b) expressing optimizations and choices as rewrite rules on DSL programs, c) designing data structures that can be configured to control the type of code that is generated and the data representation used, and d) using autotuning to select the best-performing alternative. As a case study, we implement a small, but representative subset of Spiral in Scala using the Lightweight Modular Staging (LMS) framework. The first main contribution of this paper is the realization of c) using type classes to abstract over staging decisions, i.e. which pieces of a computation are performed immediately and for which pieces code is generated. Specifically, we abstract over different complex data representations jointly with different code representations including generating loops versus unrolled code with scalar replacement - a crucial and usually tedious performance transformation. The second main contribution is to provide full support for a) and d) within the LMS framework: we extend LMS to support translation between different DSLs and autotuning through search.
The Constructivist Leader.

The Constructivist Leader provides educational leaders at all levels with a conceptual framework for leadership defined as reciprocal, purposeful learning in community. The updated Second Edition of this best-selling book enables readers to carry this constructivist vision and purpose forward, while effectively implementing standards-based reform, authentic assessment, and constructivist-based accountability. This new edition features: - An expanded theory of Constructivist Leadership reflecting the most recent thinking in leadership, learning, and ethical communities. - A comprehensive approach to issues of equity, diversity, and multiculturalism. - Additional strategies for the implementation of constructivist leadership practice. - Principles and examples to guide new approaches to accountability. - And much more!
Analysis of forward scattering radar for ground target detection

This paper describes aspects of ground target detection using a forward scattering micro radar (FSR). It begins with a brief description of the system, followed by a more detailed analytical study of FSR in terms of power budget analysis and potential cross-range resolution. From this analysis, theoretical models are constructed and compared to the experimental data
Influence of grain type, tallow level, and tallow feeding system on feedlot cattle performance.

Two experiments were conducted to evaluate the effects of grain type, tallow level, and tallow feeding system on finishing steer performance. Experiment 1 involved 256 yearling steers (359 kg) in a 4 x 2 factorial arrangement of treatments. Steers were assigned randomly to one of four tallow feeding systems: 1) 0% tallow fed throughout the experiment; 2) 4% tallow fed throughout the experiment; 3) 0% tallow fed d 1 through 33 and then 4% tallow fed until slaughter; and 4) 4% tallow fed d 1 through 33 and then 0% tallow fed until slaughter. Tallow treatments were applied to diets containing either dry-rolled corn (DRC) of high-moisture corn (HMC). No fat treatment x grain type interaction (P > .10) was observed. Steers fed 4% tallow throughout the experiment, only during d 1 through 33, or only during d 34 until slaughter were more (P < .10) efficient than steers fed 0% tallow. No differences in DMI or ADG were observed (P > .10). In Exp. 2, 120 large-framed steer calves (286 kg) were blocked by weight and allotted randomly within block to one of three treatments consisting of the addition fo 0, 2, or 4% tallow added d 1 and fed for 197 d. Feed efficiency of calves increased linearly (P < .05) with increasing tallow level. Daily gain was not different (P > .10), but DMI decreased linearly (P < .05) with increasing tallow level. This research indicates that tallow added during or after grain adaptation to DRC- or HMC-based diets fed to yearling steers will result in similar improvement in feed efficiency, and that including up to 4% tallow to diets fed to large-framed calves can significantly improve feed efficiency.
Structural differences in adult orbital and ventromedial prefrontal cortex predicted by infant temperament at 4 months of age.

CONTEXT The term temperament refers to a biologically based predilection for a distinctive pattern of emotions, cognitions, and behaviors first observed in infancy or early childhood. High-reactive infants are characterized at age 4 months by vigorous motor activity and crying in response to unfamiliar visual, auditory, and olfactory stimuli, whereas low-reactive infants show low motor activity and low vocal distress to the same stimuli. High-reactive infants are biased to become behaviorally inhibited in the second year of life, defined by timidity with unfamiliar people, objects, and situations. In contrast, low-reactive infants are biased to develop into uninhibited children who spontaneously approach novel situations. OBJECTIVE To examine whether differences in the structure of the ventromedial or orbitofrontal cerebral cortex at age 18 years are associated with high or low reactivity at 4 months of age. DESIGN Structural magnetic resonance imaging in a cohort of 18-year-olds enrolled in a longitudinal study. Temperament was determined at 4 months of age by direct observation in the laboratory. SETTING Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital. PARTICIPANTS Seventy-six subjects who were high-reactive or low-reactive infants at 4 months of age. MAIN OUTCOME MEASURE Cortical thickness. RESULTS Adults with a low-reactive infant temperament, compared with those categorized as high reactive, showed greater thickness in the left orbitofrontal cortex. Subjects categorized as high reactive in infancy, compared with those previously categorized as low reactive, showed greater thickness in the right ventromedial prefrontal cortex. CONCLUSIONS To our knowledge, this is the first demonstration that temperamental differences measured at 4 months of age have implications for the architecture of human cerebral cortex lasting into adulthood. Understanding the developmental mechanisms that shape these differences may offer new ways to understand mood and anxiety disorders as well as the formation of adult personality.
Enteropathogens identified in dogs entering a Florida animal shelter with normal feces or diarrhea.

OBJECTIVE To determine the frequency of enteropathogens in dogs entering an animal shelter with normal feces or diarrhea. DESIGN Cross-sectional study. ANIMALS 100 dogs evaluated at an open-admission municipal animal shelter in Florida. PROCEDURES Fecal samples were collected within 24 hours after admission from 50 dogs with normal feces and 50 dogs with diarrhea. Feces were tested by fecal flotation, antigen testing, PCR assay, and electron microscopy for selected enteropathogens. RESULTS 13 enteropathogens were identified. Dogs with diarrhea were significantly more likely to be infected with ≥ 1 enteropathogens (96%) than were dogs with normal feces (78%). Only Clostridium perfringens enterotoxin A gene was significantly more common in dogs with diarrhea (64%) than in dogs with normal feces (40%). Other enteropathogens identified in dogs with and without diarrhea included hookworms (58% and 48%, respectively), Giardia spp (22% and 16%, respectively), canine enteric coronavirus (2% and 18%, respectively), whipworms (12% and 8%, respectively), Cryptosporidium spp (12% and 2%, respectively), ascarids (8% and 8%, respectively), Salmonella spp (2% and 6%, respectively), Cystoisospora spp (2% and 4%, respectively), canine distemper virus (8% and 0%, respectively), Dipylidium caninum (2% and 2%, respectively), canine parvovirus (2% and 2%, respectively), and rotavirus (2% and 0%, respectively). CONCLUSIONS AND CLINICAL RELEVANCE Dogs entered the shelter with a variety of enteropathogens, many of which are pathogenic or zoonotic. Most infections were not associated with diarrhea or any specific dog characteristics, making it difficult to predict the risk of infection for individual animals. Guidelines for preventive measures and empirical treatments that are logistically and financially feasible for use in shelters should be developed for control of the most common and important enteropathogens.