Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomimetic three-dimensional nanocrystalline hydroxyapatite and magnetically synthesized single-walled carbon nanotube chitosan nanocomposite for bone regeneration

Background Many shortcomings exist in the traditional methods of treating bone defects, such as donor tissue shortages for autografts and disease transmission for allografts. The objective of this study was to design a novel three-dimensional nanostructured bone substitute based on magnetically synthesized single-walled carbon nanotubes (SWCNT), biomimetic hydrothermally treated nanocrystalline hydroxyapatite, and a biocompatible hydrogel (chitosan). Both nanocrystalline hydroxyapatite and SWCNT have a biomimetic nanostructure, excellent osteoconductivity, and high potential to improve the load-bearing capacity of hydrogels. Methods Specifically, three-dimensional porous chitosan scaffolds with different concentrations of nanocrystalline hydroxyapatite and SWCNT were created to support the growth of human osteoblasts (bone-forming cells) using a lyophilization procedure. Two types of SWCNT were synthesized in an arc discharge with a magnetic field (B-SWCNT) and without a magnetic field (N-SWCNT) for improving bone regeneration. Results Nanocomposites containing magnetically synthesized B-SWCNT had superior cytocompatibility properties when compared with nonmagnetically synthesized N-SWCNT. B-SWCNT have much smaller diameters and are twice as long as their nonmagnetically prepared counterparts, indicating that the dimensions of carbon nanotubes can have a substantial effect on osteoblast attachment. Conclusion This study demonstrated that a chitosan nanocomposite with both B-SWCNT and 20% nanocrystalline hydroxyapatite could achieve a higher osteoblast density when compared with the other experimental groups, thus making this nanocomposite promising for further exploration for bone regeneration.
An efficient geometry-constrained location estimation algorithm for NLOS environments

Mobile location estimation has attracted a significant amount of attention in recent years. The network-based location estimation schemes have been widely adopted based on the radio signals between the mobile device and the base stations. The two-step least square (LS) method has been studied in related research to provide efficient location estimation of the mobile devices. However, the algorithm results in inaccurate location estimation with the existence of the non-line-of-sight (NLOS) errors. A geometry-constrained location estimation (GLE) algorithm is proposed in this paper with the consideration of different geometric layouts between the mobile device and its associated base stations. In order to enhance the precision of the location estimate, the GLE scheme is designed to incorporate the geometric constraints within the formulation of the two-step LS method. The proposed GLE scheme can both preserve the computational efficiency from the two-step LS algorithm and obtain precise location estimation under NLOS environments. Numerical results demonstrate that the proposed GLE algorithm can achieve better accuracy, comparing with other existing schemes, in mobile location estimation.
Radiation leukemia in C57BL/6 mice. I. Lack of serological evidence for the role of endogenous ecotropic viruses in pathogenesis

The humoral immune response against endogenous ecotropic murine leukemia viruses (MuLV) was examined in irradiated and control C57BL/6 mice. Control mice developed antibodies against MuLV slowly throughout life. In contrast, within 2-3 mo after irradiation 90% of irradiated C57BL/6 mice had developed detectable antibodies against MuLV. The characteristics of this immune response, however, were identical in control and irradiated mice in terms of peak titers, specificity for endogenous ecotropic MuLV, and reactivity against the ecotropic viruses' glycoprotein (gp71). Moreover, the rate of appearance of antibodies against MuLV in irradiated mice and the peak titers were generally not affected by age at irradiation, dose of irradiation (two, three, or four treatments of 175 R), or bone marrow reconstitution. Although the ability of irradiation to accelerate the appearance of antibody in a population of C57BL/6 mice suggested activation of endogenous ecotropic MuLV, there was no apparent correlation between the appearance of this immune response or its persistence and the development of lymphoma. Thus, the incidence of lymphoma was comparable in mice that: (a) developed no immune response; (b) developed an immune response only transiently after irradiation; or (c) developed an immune response which persisted until death from lymphoma. Moreover, experimental conditions that alter the ability of irradiation to induce leukemia, such as age, dose, or bone marrow reconstitution did so without significantly altering either the rate of appearance of a humoral immune response to MuLV or its peak titers. The results, therefore, fail to demonstrate any seroepidemological relationship between endogenous ecotropic MuLV and radiation-induced leukemia.
Two EguCBF1 genes overexpressed in Eucalyptus display a different impact on stress tolerance and plant development.

Two C-repeat binding factor genes (EguCBF1a/b), isolated from E. gunnii and differentially cold-regulated, were constitutively overexpressed in a cold-sensitive Eucalyptus hybrid. In addition to the expected improvement on freezing tolerance, some resulting transgenic lines (EguCBF1a-OE and EguCBF1b-OE) exhibited a decrease in stomata density and an over-accumulation of anthocyanins also observed to a lesser extent in a cold-acclimated control plant. Given that the induction of five putative CBF target genes was observed in CBF-overexpressing lines as well as in the cold-acclimated control line, these phenotypes might be related to cold acclimation. In comparison with the control plant, the most altered transgenic line (EguCBF1a-OE A1 line), exhibited reduced growth and better water retention capacity. This modified phenotype includes reduced leaf area and thickness associated with a decrease in cell size, as well as a higher oil gland density and a wax deposition on the cuticle. Surprisingly, the EguCBF1b-OE B9 line, with a level of transgene expression equivalent to the A1 line, showed a less marked phenotype, suggesting a difference in transactivation efficiency between EguCBF1A and B factors. The features of these transgenic lines provide the first signs of adaptive mechanisms controlled by CBF transcription factors in an evergreen broad-leaved tree. These data also open new prospects towards genetic improvement on Eucalyptus for freezing tolerance.
Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously.

PURPOSE To evaluate the safety, pharmacokinetics, and biological activity of suberoylanilide hydroxamic acid (SAHA) administered by 2-h i.v. infusion in patients with advanced cancer. EXPERIMENTAL DESIGN SAHA was administered for 3 days every 21 days in part A and 5 days for 1-3 weeks in part B. Dose escalation proceeded independently in patients with solid tumor and hematological malignancies (part B only). Pharmacokinetic studies were performed along with assessment of acetylated histones in peripheral blood mononuclear cells and tumor tissues. RESULTS No dose-limiting toxicities were observed in 8 patients enrolled in part A (75, 150, 300, 600, and 900 mg/m(2)/day). Among 12 hematological and 17 solid tumor patients enrolled in part B (300, 600, and 900 mg/m(2)/day), therapy was delayed > or = 1 week for grade 3/4 leukopenia and/or thrombocytopenia in 2 of 5 hematological patients at 600 mg/m(2)/day x 5 days for 3 weeks. The maximal-tolerated dose was 300 mg/m(2)/day x 5 days for 3 weeks for hematological patients. One solid patient on 900 mg/m(2)/day x 5 days for 3 weeks developed acute respiratory distress and grade 3 hypotension. The cohort was expanded to 6 patients, and no additional dose-limiting toxicities were observed. Mean terminal half-life ranged from 21 to 58 min, and there was dose-proportional increase in area under the curve. An accumulation of acetylated histones in peripheral blood mononuclear cells up to 4 h postinfusion was observed at higher dose levels. Posttherapy tumor biopsies showed an accumulation of acetylated histones by immunohistochemistry. Four (2 lymphoma and 2 bladder) patients had objective tumor regression with clinical improvement in tumor related symptoms. CONCLUSIONS Daily i.v. SAHA is well tolerated, inhibits the biological target in vivo, and has antitumor activity in solid and hematological tumors.
A Comparative Analysis of Student Engagement between Community College Students.

CHAPTER 1: INTRODUCTION 8 Background 11 Problem Statement 12 Purpose Statement 12 Significance of the Study 13 Research Questions 14 Research Hypotheses in the Null Form 15 Identification of Variables 17 Research Plan 17 Definitions 19 CHAPTER 2: LITERATURE REVIEW 20 Introduction 20 Theoretical Framework 22 Other Comparative Studies 30 The American Community College 37 Summary 61 CHAPTER 3: METHODOLOGY 64 Design 64 Questions and Hypotheses 65 Participants 68 Setting 69 Instrumentation 70
Determinants of metabolic cost during submaximal cycling.

The metabolic cost of producing submaximal cycling power has been reported to vary with pedaling rate. Pedaling rate, however, governs two physiological phenomena known to influence metabolic cost and efficiency: muscle shortening velocity and the frequency of muscle activation and relaxation. The purpose of this investigation was to determine the relative influence of those two phenomena on metabolic cost during submaximal cycling. Nine trained male cyclists performed submaximal cycling at power outputs intended to elicit 30, 60, and 90% of their individual lactate threshold at four pedaling rates (40, 60, 80, 100 rpm) with three different crank lengths (145, 170, and 195 mm). The combination of four pedaling rates and three crank lengths produced 12 pedal speeds ranging from 0.61 to 2.04 m/s. Metabolic cost was determined by indirect calorimetery, and power output and pedaling rate were recorded. A stepwise multiple linear regression procedure selected mechanical power output, pedal speed, and pedal speed squared as the main determinants of metabolic cost (R(2) = 0.99 +/- 0.01). Neither pedaling rate nor crank length significantly contributed to the regression model. The cost of unloaded cycling and delta efficiency were 150 metabolic watts and 24.7%, respectively, when data from all crank lengths and pedal speeds were included in a regression. Those values increased with increasing pedal speed and ranged from a low of 73 +/- 7 metabolic watts and 22.1 +/- 0.3% (145-mm cranks, 40 rpm) to a high of 297 +/- 23 metabolic watts and 26.6 +/- 0.7% (195-mm cranks, 100 rpm). These results suggest that mechanical power output and pedal speed, a marker for muscle shortening velocity, are the main determinants of metabolic cost during submaximal cycling, whereas pedaling rate (i.e., activation-relaxation rate) does not significantly contribute to metabolic cost.
Stellar, brown dwarf and multiple star properties from hydrodynamical simulations of star cluster formation

We report the statistical properties of stars, brown dwarfs and multiple systems obtained from the largest hydrodynamical simulation of star cluster formation to date that resolves masses down to the opacity limit for fragmentation (a few Jupiter masses). The simulation is essentially identical to that of Bate, Bonnell & Bromm except that the initial molecular cloud is larger and more massive. It produces more than 1250 stars and brown dwarfs, providing unprecedented statistical information that can be compared with observational surveys. The calculation uses sink particles to model the stars and brown dwarfs. Part of the calculation is rerun with smaller sink particle accretion radii and gravitational softening to investigate the effect of these approximations on the results. We find that hydrodynamical/sink particle simulations can reproduce many of the observed stellar properties very well. Multiplicity as a function of the primary mass, the frequency of very low mass (VLM) binaries, general trends for the separation and mass ratio distributions of binaries and the relative orbital orientations of triples systems are all in reasonable agreement with observations. We also examine the radial variations of binarity, velocity dispersion and mass function in the resulting stellar cluster and the distributions of disc truncation radii due to dynamical interactions. For VLM binaries, because their separations are typically close, we find that their frequency is sensitive to the sink particle accretion radii and gravitational softening used in the calculations. Using small accretion radii and gravitational softening results in a frequency of VLM binaries similar to that expected from observational surveys (≈20 per cent). We also find that VLM binaries evolve from wide, unequal-mass systems towards close equal-mass systems as they form. The two main deficiencies of the calculations are that they overproduce brown dwarfs relative to stars and that there are too few unequalmass binaries with K- and G-dwarf primaries. The former of these is likely due to the absence of radiative feedback and/or magnetic fields.
Ram pressure stripping of disc galaxies: the role of the inclination angle

We present three-dimensional (3D) hydrodynamical simulations of ram pressure stripping of massive disc galaxies in clusters. Studies of galaxies that move face-on have predicted that in such a geometry the galaxy can lose a substantial amount of its interstellar medium. But only a small fraction of galaxies is moving face-on. In this work we focus on a systematic study of the effect of the inclination angle between the direction of motion and the galaxy's rotation axis. In agreement with some previous works, we find that the inclination angle does not play a major role for the mass loss as long as the galaxy is not moving close to edge-on (inclination angle ≲60°). We explain this behaviour by extending Gunn & Gott's estimate of the stripping radius, which is valid for face-on geometries, to moderate inclinations. The inclination plays a role as long as the ram pressure is comparable to pressures in the galactic plane, which can span two orders of magnitude. For very strong ram pressures, the disc will be stripped completely, and for very weak ram pressures, mass loss is negligible independent of inclination. We show that in non-edge-on geometries the stripping proceeds remarkably similar. A major difference between different inclinations is the degree of asymmetry introduced in the remaining gas disc. We demonstrate that the tail of gas stripped from the galaxy does not necessarily point in a direction opposite to the galaxy's direction of motion. Therefore, the observation of a galaxy's gas tail may be misleading about the galaxy's direction of motion.
Masculinization in physical activity and sport sciences degree programs.

Educational differences between men and women are reflected in their career choices. Likewise, physical education, physical activity and sports offer a broad arena for gender socialization. The aim of this paper is to analyze the presence of women in degree programs related to physical education, physical activity and sport taught in Catalonia during the past 25 years. The results show that there has been a decrease in the presence of women in the aforementioned degrees, confirming a masculinization process in this area of knowledge. The tendency of the diminishing number of women contrasts with the rising percentage of women participating in sports. This para-dox calls for a necessary change in these degree programs which would entail including females’ ways of seeing and experiencing physical activity, physical education and sports.
Geometric algorithms for transposition invariant content based music retrieval

We represent music as sets of points or sets of horizontal line segments in the Euclidean plane. Via this geometric representation we cast transposition invariant content-based music retrieval problems as ones of matching sets of points or sets of horizontal line segments in plane under translations. For finding the exact occurrences of a point set (the query pattern) of size within another point set (representing the database) of size , we give an algorithm with running time , and for finding partial occurrences another algorithm with running time . We also use the total length of the overlap between the line segments of a translated query and a database (i.e., the shared time) as a quality measure of an occurrence and present an algorithm for finding translations giving the largest possible overlap. Some experimental results on the performance of the algorithms are reported.
Foliations Transverse to Triangulations of 3-Manifolds

We investigate the combinatorial analogues, in the context of normal surfaces, of taut and transversely measured (codimension 1) foliations of 3-manifolds. We establish that the existence of certain combinatorial structures, a priori weaker than the existence of the corresponding foliation, is sufficient to guarantee that the manifold in question satisfies certain properties, e.g. irreducibility. The finiteness of our combinatorial structures allows us to make our results quantitative in nature and has (coarse) geometrical consequences for the manifold. Furthermore, our techniques give a straightforward combinatorial proof of Novikov's theorem.
Determinants of Firm Performance and Growth During Economic Recession: The Case of Central and Eastern European Countries

The crisis has hit the corporate sectors of the new EU member states from Central and Eastern European countries (CEECs) more than those of most old EU member states. Taking full account of firms’ heterogeneity, the paper analyses what kind of CEECs firms’ characteristics make some of them more resilient to crisis than the others. Using panel VAR system on a large firm-level dataset we estimate the responses of firms’ employment and investment to cyclical demand shocks and financial shocks. Controlling for industry, time and country differences, we split firms according to size, age, export status, foreign versus domestic ownership and pre- vs. during crisis growth in order to compare firms’ responses between distinct splits. We find that cyclical drop in demand decreases firms’ employment in subsequent periods but there is substantial heterogeneity among different types of firms. Old and especially small old firms react more swiftly, whereas downward adjustment in employment is less severe in exporters and in foreign-owned firms. On the other hand, investment does not respond to demand shocks per se, but to free cash flow component of the business cycle. It is large young firms that are the most and small young firms that are the least responsive to financial shocks in terms of investment activity. In contrast to employment adjustments, exporters adjust their investment activity to cash flow availability to a larger extent than non-exporters. Differences in country specific settings also show important impact on firms’ resistance to crisis. The quality of legal institutional environment in a country is positively correlated with the employment sensitivity to shocks but it has no discernible effect on investment sensitivity. On the other hand, political and economic institutions make employment more stable over the cycle.
Growth and Convergence across the United States: Evidence from County-Level Data

Abstract We use U.S. county data (3,058 observations) and 41 conditioning variables to study growth and convergence. Using ordinary least squares (OLS) and three-stage least squares with instrumental variables (3SLS-IV), we report on the full sample and metro, nonmetro, and and regional samples: (1) OLS yields convergence rates around 2%; 3SLS yields 6%–8%; (2) convergence rates vary (for example, the Southern rate is 2.5 times the Northeastern rate); (3) federal, state, and local government negatively correlates with growth; (4) the relationship between educational attainment and growth is nonlinear; and (5) the finance, insurance, and real estate industry and the entertainment industry correlate positively with growth, whereas education employment correlates negatively.
Proximity and Coresidence of Adult Children and Their Parents in the United States: Description and Correlates

In this paper we provide an overview of the patterns of intergenerational proximity and coresidence of adult children and their mothers in the U.S., using data from the National Survey of Families and Households (NSFH) and the U.S. Census. We highlight the importance of three specification and sample choices in the analysis. First, most previous studies consider coresidence to be the limiting case of proximity, using Tobit, ordered logit, or ordered probit specifications. We argue that proximity and coresidence are qualitatively different, and show that the multinomial logit provides a better representation of the patterns in the data. Second, we argue that substantial differences in the correlates of proximity by gender and marital status indicate the importance of modeling these categories separately. Third, the NSFH allows us to consider the proximity of couples to both his mother and her mother. This information is rarely available in survey data but is important for complete analyses. Our results show that education and age are the most robust predictors of proximity: college graduates are less likely to live near their mothers and older children live further from their mothers. Other demographic variables such as race, ethnicity and only child status also affect the probability of close proximity and coresidence. However, characteristics indicating adult children's current need for transfers (e.g. grandchildren) are not correlated with either close proximity or coresidence, while characteristics indicating mothers' current needs for transfers (e.g., disability) are correlated with coresidence but not close proximity.
Management of open bite that developed during treatment for internal derangement and osteoarthritis of the temporomandibular joint

This case report describes the orthodontic treatment performed for open bite caused by internal derangement (ID) and osteoarthritis (OA) of the temporomandibular joint (TMJ). A Japanese woman, aged 31 years and 11 months, referred to our department by an oral surgeon had an open bite with clockwise rotation of the mandible and degeneration of the condyle. The overbite was corrected through intrusion of the maxillary and mandibular molars using mini-screw implants to induce counterclockwise rotation of the mandible. Then, the mandibular second premolars were extracted and comprehensive orthodontic treatment was performed to establish a Class I molar relationship with distalization of the maxillary arch and to eliminate anterior crowding. Following treatment, her facial profile improved and a functional and stable occlusion was achieved without recurrence of the TMJ symptoms. These results suggest that orthodontic intrusion of the molars is one of the safer and less stressful alternatives for the management of open bite due to degeneration of the condyles caused by ID and OA of TMJ.