Miracle-dz/UniFAR-FTUs huggingface dataset:
STAT2 phosphorylation and signaling

STAT2 is an essential transcription factor in type I IFN mediated anti-viral and anti-proliferative signaling. STAT2 function is regulated by tyrosine phosphorylation, which is the trigger for STAT-dimerization, subsequent nuclear translocation, and transcriptional activation of IFN stimulated genes. Evidence of additional STAT2 phosphorylation sites has emerged as well as novel roles for STAT2 separate from the classical ISGF3-signaling. This review aims to summarize knowledge of phosphorylation-mediated STAT2-regulation and future avenues of related STAT2 research.
Exercises versus arthroscopic decompression in patients with subacromial impingement: a randomised, controlled study in 90 cases with a one year follow up

Objectives: To compare the effect of graded physiotherapeutic training of the rotator cuff versus arthroscopic subacromial decompression in patients with subacromial impingement. Methods: Randomised controlled trial with 12 months’ follow up in a hospital setting. Ninety consecutive patients aged 18 to 55 years were enrolled. Symptom duration was between six months and three years. All fulfilled a set of diagnostic criteria for rotator cuff disease, including a positive impingement sign. Patients were randomised either to arthroscopic subacromial decompression, or to physiotherapy with exercises aiming at strengthening the stabilisers and decompressors of the shoulder. Outcome was shoulder function as measured by the Constant score and a pain and dysfunction score. “Intention to treat” analysis was used, with comparison of means and control of confounding variables by general equation estimation analysis. Results: Of 90 patients enrolled, 84 completed follow up (41 in the surgery group, 43 in the training group). The mean Constant score at baseline was 34.8 in the training group and 33.7 in the surgery group. After 12 months the mean scores improved to 57.0 and 52.7, respectively, the difference being non-significant. No group differences in mean pain and dysfunction score improvement were found. Conclusions: Surgical treatment of rotator cuff syndrome with subacromial impingement was not superior to physiotherapy with training. Further studies are needed to qualify treatment choice decisions, and it is recommended that samples are stratified according to disability level.
Fixed-Form Variational Posterior Approximation through Stochastic Linear Regression

textabstractWe propose a general algorithm for approximating nonstandard Bayesian posterior distributions. The algorithm minimizes the Kullback-Leibler divergence of an approximating distribution to the intractable posterior distribu- tion. Our method can be used to approximate any posterior distribution, provided that it is given in closed form up to the proportionality constant. The approxi- mation can be any distribution in the exponential family or any mixture of such distributions, which means that it can be made arbitrarily precise. Several exam- ples illustrate the speed and accuracy of our approximation method in practice.
Reflections on Critical Incidents of EFL Teachers During Career Entry in Central Mexico

This article explores the reflections of critical incidents of eight beginning English as a foreign language teachers and one of their trainers in Mexico. Based upon narrative inquiry and through the use of journals, critical incidents and how they have impacted beginning teachers in their thinking were specifically looked at. From the data we found seven emerging themes which basically revolve around the relationships that are established between the teacher and the students, the emerging professional identities of the beginning teachers, and the tutor’s reflection on knowledge transfer. Results showed how these teachers reflected upon their teaching practice and how the critical incidents helped them to analyze and evaluate their teaching process.
An Empirical Examination of the Strength Differential Hypothesis in Cyberbullying Behavior

Objective: Two studies were conducted to (re)examine whether the strength differential hypothesis—that face-to-face bullies are likely to be physically stronger than victims—is valid in the cyberbullying domain. The novel contribution of our research includes testing the relations between the belief that strength is irrelevant for online bullying, online power (technological abilities), and cyberbullying within the theoretical integration of the Barlett and Gentile cyberbullying model and Bandura’s self-efficacy theory. Method: Two studies had participant’s complete measures of cyberbullying behavior, cyberbullying attitudes, online power, and the belief that strength is irrelevant for online bullying. Study 1 (N = 147) utilized a cross-sectional design with a general adult population, whereas Study 2 (N = 218) employed a short-term longitudinal study of college students. Results: Correlation and regression findings from Study 1 showed that (a) the belief that muscularity is irrelevant for online bullying (but not online power) was associated with more cyberbullying, and (b) this relation was mediated by cyberbullying attitudes. Study 2 replicated these results using a longitudinal path analysis. Conclusion: The current research supports the postulates of the BGCM by confirming the theoretically predicted relations between the belief that muscularity is irrelevant in the online world and cyberbullying behavior through the development of cyberbullying attitudes. Online power, in the form of computer skill, did not show this pattern, suggesting that perceptions of physical strength are more relevant even in the online world, supporting the original strength differential hypothesis.
Comparable Ascertainment of Newly-Diagnosed Atrial Fibrillation Using Active Cohort Follow-Up versus Surveillance of Centers for Medicare and Medicaid Services in the Atherosclerosis Risk in Communities Study

Objective Increasingly, epidemiologic studies use administrative data to identify atrial fibrillation (AF). Capture of incident AF is not well documented. We examined incidence rates and concordance of AF diagnosis based on active cohort follow-up versus surveillance of Centers for Medicare and Medicaid Services data in the Atherosclerosis Risk in Communities study. Methods Atherosclerosis Risk in Communities cohort participants without prevalent AF enrolled in fee-for-service Medicare, with inpatient and outpatient coverage, for at least 12 continuous months between 1991 and 2009 were included. In active Atherosclerosis Risk in Communities study follow-up, annual telephone calls captured hospitalizations and deaths with incident AF diagnosis codes. For Centers for Medicare and Medicaid Services data, incident AF was defined by billed inpatient and outpatient diagnoses. Results Of 10,134 eligible cohort participants, 738 developed AF according to both Atherosclerosis Risk in Communities and Centers for Medicare and Medicaid Services data; an additional 93 and 288 incident cases were identified using only Atherosclerosis Risk in Communities and Centers for Medicare and Medicaid Services data, respectively. Incidence rates per 1,000 person-years were 10.8 (95% confidence interval: 10.1–11.6) and 13.6 (95% confidence interval: 12.8–14.4) in Atherosclerosis Risk in Communities and Centers for Medicare and Medicaid Services, respectively; agreement was 96%; kappa was 0.77 (95% confidence interval: 0.75–0.80). Earlier AF ascertainment by one system versus the other was not associated with any cardiovascular disease risk factors, after accounting for sociodemographic factors. Additional Centers for Medicare and Medicaid Services events did not alter observed associations between risk factors and AF. Conclusion Among fee-for-service enrollees, AF incidence rates were slightly lower for active cohort follow-up than for Centers for Medicare and Medicaid Services surveillance, because the latter included outpatient atrial fibrillation. Concordance was high and combining the two approaches could provide a more complete picture of newly-diagnosed AF.
Hormonal regulation of the hypothalamic melanocortin system

Regulation of energy homeostasis is fundamental for life. In animal species and humans, the Central Nervous System (CNS) plays a critical role in such regulation by integrating peripheral signals and modulating behavior and the activity of peripheral organs. A precise interplay between CNS and peripheral signals is necessary for the regulation of food intake and energy expenditure in the maintenance of energy balance. Within the CNS, the hypothalamus is a critical center for monitoring, processing and responding to peripheral signals, including hormones such as ghrelin, leptin, and insulin. Once in the brain, peripheral signals regulate neuronal systems involved in the modulation of energy homeostasis. The main hypothalamic neuronal circuit in the regulation of energy metabolism is the melanocortin system. This review will give a summary of the most recent discoveries on the hormonal regulation of the hypothalamic melanocortin system in the control of energy homeostasis.
Robust visual odometry to irregular illumination changes with RGB-D camera

Sensitivity to illumination conditions poses a challenge when utilizing visual odometry (VO) in various applications. To make VO robust with respect to illumination conditions, they need to be considered explicitly. In this paper, we propose a direct visual odometry method which can handle illumination changes by considering an affine illumination model to compensate abrupt, local light variations during direct motion estimation process. The core of our proposed method is to estimate the relative camera pose and the parameters of the illumination changes by minimizing the sum of squared photometric error with efficient second-order minimization. We evaluate the performance of the proposed algorithm on synthetic and real RGB-D datasets with ground-truth. Our result implies that the proposed method successfully estimates 6-DoF pose under significant illumination changes whereas existing direct visual odometry methods either fail or lose accuracy.
Loan Guarantees for Consumer Credit Markets

Loan guarantees are arguably the most widely used policy intervention in credit markets, especially for consumers. This may be natural, as they have several features that, a priori, suggest that they might be particularly effective in improving allocations. However, despite this, little is actually known about the size of their effects on prices, allocations, and welfare. ; In this paper, we provide a quantitative assessment of loan guarantees, in the context of unsecured consumption loans. Our work is novel as it studies loan guarantees in a rich dynamic model where credit allocation is allowed to be affected by both limited commitment frictions and private information. ; Our findings suggest that consumer loan guarantees may be a powerful tool to alter allocations that, if carefully arranged, can improve welfare, sometimes significantly. Specifically, our key findings are that (i) under both symmetric and asymmetric information, guaranteeing small consumer loans nontrivially alters allocations, and strikingly, yields welfare improvements even after a key form of uncertainty? one's human capital level? has been realized, (ii) larger guarantees change allocations very significantly, but lower welfare, sometimes for all household-types, and (iii) substantial further gains are available when guarantees are restricted to households hit by large expenditure shocks.
Employee perceptions of organisational legitimacy as impersonal bases of organisational trustworthiness and trust

ABSTRACT Prior research has amply demonstrated that employees’ personal relationship with the organisation influences their trust in it. In this two-study investigation, we examine how employees’ beliefs about the organisation’s legitimacy relate to their organisational trust because legitimacy signals organisational trustworthiness in the impersonal system of the institutional environment. Results from Study 1, which drew on data from one organisation, reveal that employees’ legitimacy beliefs are related to their organisational trust. Furthermore, results from Study 2, which are based on data from five organisations, reveal that employees’ judgment of the organisation’s trustworthiness mediates the relationship between legitimacy beliefs and organisational trust. Overall, our findings create a new avenue for trust research by advancing the idea that employees' trust in their employer organisation derives in part from the reflection of trustworthiness that arises due to the organisation’s association with the institutional environment.
Let the right one in: ethnic boundaries in a Colombian immigrant youth program

Abstract Although research on minority youth has established the value of coethnic spaces for safe ethnic identity exploration, research has seldom examined how youth in these spaces draw ethnic boundaries or offered appropriate frameworks addressing boundary-setting. This study uses Berry’s acculturation framework to explore ethnic boundary-setting within a Colombian immigrant youth dance program in the US. Seven members participated in a multi-year qualitative study that triangulated surveys, interviews, and responses to a hypothetical multicultural dilemma that ‘positioned’ Colombian participants as part of an in-group on the basis of their ethnicity. Specifically, it explores the strategies they employed to deal with the dilemma and the role context played in those strategies. With findings that reveal how youth incorporate the arguments found in mainstream immigration debates to justify integration, segregation, and exclusion of non-Colombians, this study argues that to understand strategies employed, it is necessary to examine local, national, and transnational contexts.
An examination of speechreading and spelling accuracy with high school students who are deaf or hard of hearing

Numerous studies have demonstrated that spelling presents unique challenges for children who are deaf or hard of hearing (d/hh) and most do not develop age appropriate spelling skills. For these children, information about the sound structure of a word is reduced due to limited auditory input. However, children who are d/hh do have access to visual information about the sounds in words through speechreading. The objective of this study was to explore the degree to which speechreading cues are used to support spelling during a single word spelling test. Fourteen high school students who are d/hh from a state school for the Deaf, participated in two spelling conditions; Condition A in which visual information from speechreading was available and Condition B in which it was not. Spelling errors were coded by Condition for overall accuracy and accuracy based upon the visibility of the initial sound and the ambiguity of the American Sign Language (ASL) sign or picture. A multi-linguistic coding system was also used to assess each child's understanding of the phonological, morphological, orthographic, semantic, and visual imagery rules that apply to written words. Results show that total scores in both Conditions were low although spelling accuracy for the words with ambiguous signs and pictures improved when visual information from speechreading was available. The visibility of the initial speech sound did not affect test scores. The multi-linguistic analysis showed that the participants produced more semantic, morphological, and phonological errors than other errors types. The results from this study suggest that, at least with this group of participants, there is a need for greater emphasis on teaching the linguistic foundations that guide spelling, coupled with an emphasis on using the visual speech signal to obtain linguistic information.
New records of Mansonella ozzardi: a parasite that is spreading from the state of Amazonas to previously uninfected areas of the state of Acre in the Purus River region

Mansonella ozzardi infections are common in the riverside communities along the Solimões, Negro and Purus Rivers in the state of Amazonas (AM). However, little is known about the presence of this parasite in communities located in regions bordering AM and the state of Acre. The prevalence rate of M. ozzardi infections was determined in blood samples from volunteers according to the Knott method. A total of 355 volunteers from six riverine communities were enrolled in the study and 65 (18.3%) were found to be infected with M. ozzardi. As expected, most of the infections (25%) occurred in individuals involved in agriculture, cattle rearing and fishing and an age/sex group analysis revealed that the prevalence increased beginning in the 40-50-years-of-age group and reached 33% in both sexes in individuals over 50 years of age. Based on the described symptomatology, articular pain and headache were found to be significantly higher among infected individuals (56 and 65% prevalence, respectively, p < 0.05). Sera from volunteers were subjected to ELISA using a cocktail of recombinant proteins from Onchocerca volvulus to evaluate the specificity of the test in an endemic M. ozzardi region. No cross-reactions between M. ozzardi-infected individuals and recombinant O. volvulus proteins were detected, thus providing information on the secure use of this particular cocktail in areas where these parasites are sympatric.
A Real-Life Study in Phishing Detection

Phishing is a serious threat to global security and economy. Previously we have developed a phishing ltering system based on automatic classication. We perform statistical ltering of emails, where a classier is trained on characteristic features of existing emails and subsequently is able to identify new phishing emails with dierent contents. In this work we test our developed system in a real-life environment at a commercial ISP. The system is applied to an unskewed real-life stream consisting of thousands of emails every day. We use active learning to keep the system’s model up-todate. The experiments show that the system performs very well as a lter even in the presence of many spam emails. We furthermore demonstrate that active learning is indeed useful and leads to better results than using a xed model. Last, we integrate the output of another spam lter into the system and show that this combined lter leads to better results than either lter by itself.
Formaldehyde in Alcoholic Beverages: Large Chemical Survey Using Purpald Screening Followed by Chromotropic Acid Spectrophotometry with Multivariate Curve Resolution

A strategy for analyzing formaldehyde in beer, wine, spirits, and unrecorded alcohol was developed, and 508 samples from worldwide origin were analyzed. In the first step, samples are qualitatively screened using a simple colorimetric test with the purpald reagent, which is extremely sensitive for formaldehyde (detection limit 0.1 mg/L). 210 samples (41%) gave a positive purpald reaction. In the second step, formaldehyde in positive samples is confirmed by quantitative spectrophotometry of the chromotropic acid-formaldehyde derivative combined with Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS). Calculation of UV-VIS and 13C NMR spectra confirmed the monocationic dibenzoxanthylium structure as the product of the reaction and disproved the widely cited para,para-quinoidal structure. Method validation for the spectrophotometric procedure showed a detection limit of 0.09 mg/L and a precision of 4.2–8.2% CV. In total, 132 samples (26%) contained formaldehyde with an average of 0.27 mg/L (range 0–14.4 mg/L). The highest incidence occurred in tequila (83%), Asian spirits (59%), grape marc (54%), and brandy (50%). Our survey showed that only 9 samples (1.8%) had formaldehyde levels above the WHO IPCS tolerable concentration of 2.6 mg/L.
Seeing Sounds and Hearing Colors: An Event-related Potential Study of Auditory–Visual Synesthesia

In auditory–visual synesthesia, sounds automatically elicit conscious and reliable visual experiences. It is presently unknown whether this reflects early or late processes in the brain. It is also unknown whether adult audiovisual synesthesia resembles auditory-induced visual illusions that can sometimes occur in the general population or whether it resembles the electrophysiological deflection over occipital sites that has been noted in infancy and has been likened to synesthesia. Electrical brain activity was recorded from adult synesthetes and control participants who were played brief tones and required to monitor for an infrequent auditory target. The synesthetes were instructed to attend either to the auditory or to the visual (i.e., synesthetic) dimension of the tone, whereas the controls attended to the auditory dimension alone. There were clear differences between synesthetes and controls that emerged early (100 msec after tone onset). These differences tended to lie in deflections of the auditory-evoked potential (e.g., the auditory N1, P2, and N2) rather than the presence of an additional posterior deflection. The differences occurred irrespective of what the synesthetes attended to (although attention had a late effect). The results suggest that differences between synesthetes and others occur early in time, and that synesthesia is qualitatively different from similar effects found in infants and certain auditory-induced visual illusions in adults. In addition, we report two novel cases of synesthesia in which colors elicit sounds, and vice versa.
Muscle innervation patterns for human wrist control: Useful biofeedback signals for robotic rehabilitation?

Upper limb robotic rehabilitation technology has recognized the importance of biofeedback signals for optimizing motor recovery. Impaired motor control is typically associated with abnormal muscle activation patterns and such patterns can be revealed by electromyography (EMG). However, before using user-generated EMG signals as biofeedback for controlling and optimizing force output of a robot, it is imperative that the healthy muscle innervation patterns are fully established to guide possible robot-aided rehabilitation protocols. Given the muscular redundancy found in many human limb systems, and given that force generation of human muscles is not linear, it becomes important to understand how synergistic control influences joint force and joint kinematics. It is the purpose of this study to map the electromyographic activation patterns of the major human muscles involved in controlling the hand/wrist system. By means of a robotic exoskeleton three Degrees of Freedom (DoF) were evaluated: wrist flexion-extension and adduction-abduction as well as forearm pronation-supination separately and for different ranges of the workspace. We recorded EMG activity of 7 arm muscles of 4 healthy subjects performing the task and we therefore defined the typical EMG activation patterns of such muscles during robotic training.
Stimulus-Response Compatibility Effect in the Near-Far Dimension: A Developmental Study

The present study investigates the developmental aspect of stimulus-response compatibility (SRC) effect in 8–11-years-old children. The task consisted in manually responding to the color of a pawn presented on a chessboard at different distances. Manual responses were provided by reaching a proximal or distal location depending on the color of the stimulus. We found that reaction time was affected by the conflict generated by the response suggested by the location of the stimulus and the response required according to its color. This was not the case for movement time despite we found a higher rate of long duration movements in the incongruent than in the congruent spatial condition. The SRC effect was, however, observed in children older than 10 years old. These findings provide additional evidence for a reorganization of the perceptual system during the period of 8–10 years, integrating progressively multimodal information and preparing more efficiently the body to act in the environment.