Miracle-dz/UniFAR-FTUs huggingface dataset:
Spectrally Efficient 168 Gb/s/λ WDM 64-QAM Single-Sideband Nyquist-Subcarrier Modulation With Kramers–Kronig Direct-Detection Receivers

Due to their simple and cost-effective transceiver architecture, single-polarization and single-photodiode-based direct-detection (DD) systems offer advantages for metropolitan area network and data-center interconnect applications. Single-sideband subcarrier modulation (SSB SCM) signaling with DD has the potential to achieve high information spectral density (ISD) but its performance can be significantly degraded by signal–signal beat interference (SSBI). The recently proposed Kramers–Kronig (KK) digital signal processing scheme is effective in eliminating the SSBI penalty. Through the use of the KK scheme, we achieved 4 × 168 Gb/s wavelength division multiplexing DD SSB 64-QAM Nyquist-SCM signal transmission over 80 km of uncompensated standard single-mode fiber at a net ISD of up to 4.61 (b/s)/Hz. The joint optimization of the optical carrier-to-signal power ratio and the KK algorithm sampling rate is described.
Unifying Models of Churn and Resilience for Unstructured P2P Graphs

Previous analytical results on the resilience of unstructured P2P systems have not explicitly modeled heterogeneity of user churn (i.e, difference in online behavior) or the impact of in-degree on system resilience. To overcome these limitations, we introduce a unifying model of heterogeneous user churn and derive the distribution of the various metrics observed in prior experimental studies. We also show that the arrival process of in-edges to each user converges to Poisson when system size tends to infinity, model transient behavior of in-degree, and apply these results to obtain the joint in/out-degree isolation probability.
Racial differences in presentations and predictors of acute pain after motor vehicle collision

Abstract African Americans experience a greater burden of acute pain than non-Hispanic white individuals across of variety of acute medical conditions, but it is unknown whether this is the case after trauma. We evaluated pain, pain-related characteristics (eg, peritraumatic distress), and analgesic treatment in 2 cohorts of individuals (African American [n = 931] and non-Hispanic white [n = 948]) presenting to the emergency department (ED) after a motor vehicle collision. We performed a propensity-matched analysis (n = 796 in each group) to assess racial differences in acute pain in the ED. In multivariable models conducted within the matched sample, race was associated with moderate to severe axial pain (odds ratio [OR] 3.2; 95% confidence interval [CI]: 2.1-5.0, P < 0.001) and higher average numerical rating scale scores (1.3; 95% CI: 1.1-1.6; P < 0.001). After adjustment for pain and other covariates, non-Hispanic white patients were more likely to receive an opioid analgesic in the ED (OR 2.0; 95% CI: 1.4-3.0, P < 0.001) or at discharge (OR 4.9; 95% CI: 3.4-7.1, P < 0.001) and also less likely to receive an NSAID in the ED (OR 0.54; 95% CI: 0.38-0.78; P = 0.001) or at discharge (0.31; 95% CI: 0.43-0.84). Racial differences in the severity of acute posttraumatic pain after a motor vehicle collision are not explained by factors such as socioeconomic status or crash characteristics. Despite a higher burden of acute pain, African Americans were less likely to receive opioid analgesics and more likely to receive NSAIDs. Further work is needed to understand the relationship between pain severity, disparities in analgesic treatment, and longer term outcomes, such as post–motor vehicle collision chronic pain.
Physical exercise induces expression of CD31 and facilitates neural function recovery in rats with focal cerebral infarction

Abstract Objectives: The present study was aimed at examining the role of physical exercise in the improvement of damaged neural function and the induction of angiogenesis. Methods: An infarction model was induced by ligating the left middle cerebral artery occlusion (MCAO) in a total of 66 adult Sprague–Dawley rats that were further randomly divided into three groups: the physical exercise group (n=30), which was given running wheel exercise every day after MCAO, the control group (n=30) and sham-operated group (n=6), which were fed in standard cages without any special training exercise. The rats were killed on the third, seventh and fourteenth days and the neurological severity scores were examined for evaluating the neural function. And the neogenetic microvessels around the peri-infarction region were checked with the specific marker CD31. Results: Although neogenetic microvessels in the peri-infarction region were observed in both control group and physical exercise group, which showed the highest signal on the seventh day after ischemia, the number of CD31 positive cells significantly increased in physical exercise group in comparison with those in control group on the seventh and fourteenth days after ischemia (p<0·01). Moreover, the neurological severity scores in the physical exercise group showed more quick declination as compared to those in control group from the seventh day after ischemic. Conclusion: Our results suggested that physical exercise plays an important role in the recovery of damaged neural function and induction of angiogenesis after cerebral infarction in rats.
Evaluation of Intradialytic Hypertension Using Bioelectrical Impedance Combined With Echocardiography in Maintenance Hemodialysis Patients

Although intra‐dialytic hypertension (IDH) has been noted in clinical settings for many years, its pathogenesis remains unclear. In this cross‐sectional study, we analyzed IDH incidence in our center and the correlation between postdialysis volume state and IDH. One hundred thirty‐one maintenance hemodialysis (MHD) patients were enrolled in our study, and bioelectrical impedance (BIA) and echocardiography (ECG) were recorded. In addition, demographic data were collected, and laboratory examinations were conducted. The patients were grouped into four groups according to the change in systolic blood pressure (SBP) between predialysis and postdialysis. The incidence of IDH was 10.7%. The proportion of extracellular water to total body weight (ECW/TW), as evaluated by BIA, was significantly higher in the IDH group than in the other three groups both in pre‐and post‐dialysis. In particular, postdialysis SBP was highest in the highest tertile interval of ECW/TW. In addition, among the four groups, left ventricular volume (LVV) was highest in the IDH group. Binary logistic analyses revealed that predialysis SBP, postdialysis ECW/TW and LVV were independent risk factors of intradialytic hypertension. When predicting IDH, the AUC of the ROC curve was higher for ECW/TW combined with LVV (0.752, 95% CI 0.613–0.896) than for either LVV or ECW/TW alone. Our study further showed that post‐dialysis volume expansion is an important factor for the development of IDH.
TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding

Transgenic tumour necrosis factor alpha (TNFα)-driven models of polyarthritis such as the TNFΔARE mouse have proven to be invaluable in delineating aspects of inflammatory disease pathophysiology in humans. Unfortunately, the onset of joint destruction and inflammation in these models represents a significant detriment to breeding management. We examined whether TNFα depleting therapy ‘infliximab’ might represent a significant refinement in routine breeding. Clinical scores of joint inflammation were assessed in TNFΔARE males receiving either infliximab (10 mg/kg) or saline by twice-weekly intraperitoneal injection. Joint histology and bone morphology were assessed by histological analysis and micro-computed tomography (CT), respectively. Analysis of breeding was examined retrospectively in TNFΔARE males prior to, and following, regular introduction of infliximab. Clinical scores of inflammation were significantly reduced in TNFΔARE males receiving infliximab (control 6.6 arbitrary units [AU] ± 0.88 versus infliximab 4.4 AU ± 1.4; P < 0.05), while measures of pannus invasion and bone erosion by histology and micro-CT were markedly reduced. In the breeding groups, TNFΔARE males receiving infliximab injections sired more litters over their breeding lifespan (control 1.69 ± 0.22 versus infliximab 3.00 ± 0.19; P < 0.005). Furthermore, prior to infliximab, TNFΔARE males had a 26% risk of failing to sire any litters. This was reduced to 7% after the introduction of infliximab. This study is the first to report that regular administration of infliximab is effective at suppressing disease activity and improving animal welfare in TNFΔARE animals. In addition, we have shown that infliximab is highly efficacious in improving breeding behaviour and increasing the number of litters sired by TNFΔARE males.
Interhemispheric functional interactions between the subthalamic nuclei of patients with Parkinson's disease

Parkinson's disease (PD) is characterized by widespread neural interactions in cortico‐basal‐ganglia networks primarily in beta oscillations (approx. 10–30 Hz), as suggested by previous findings of levodopa‐modulated interhemispheric coherence between the bilateral subthalamic nuclei (STN) in local field potential recordings (LFPs). However, due to confounding effects of volume conduction the existence of ‘genuine’ interhemispheric subcortical coherence remains an open question. To address this issue we utilized the imaginary part of coherency (iCOH) which, in contrast to the standard coherence, is not susceptible to volume conduction. LFPs were recorded from eight patients with PD during wakeful rest before and after levodopa administration. We demonstrated genuine coherence between the bilateral STN in both 10–20 and 21–30 Hz oscillations, as revealed by a non‐zero iCOH. Crucially, increased iCOH in 10–20 Hz oscillations positively correlated with the worsening of motor symptoms in the OFF medication condition across patients, which was not the case for standard coherence. Furthermore, across patients iCOH was increased after levodopa administration in 21–30 Hz oscillations. These results suggest a functional distinction between low and high beta oscillations in STN‐LFP in line with previous studies. Furthermore, the observed functional coupling between the bilateral STN might contribute to the understanding of bilateral effects of unilateral deep brain stimulation. In conclusion, the present results imply a significant contribution of time‐delayed neural interactions to interhemispheric coherence, and the clinical relevance of long‐distance neural interactions between bilateral STN for motor symptoms in PD.
Patient-derived glioblastoma stem cells respond differentially to targeted therapies

The dismal prognosis of glioblastoma is, at least in part, attributable to the difficulty in eradicating glioblastoma stem cells (GSCs). However, whether this difficulty is caused by the differential responses of GSCs to drugs remains to be determined. To address this, we isolated and characterized ten GSC lines from established cell lines, xenografts, or patient specimens. Six lines formed spheres in a regular culture condition, whereas the remaining four lines grew as monolayer. These adherent lines formed spheres only in plates coated with poly-2-hydroxyethyl methacrylate. The self-renewal capabilities of GSCs varied, with the cell density needed for sphere formation ranging from 4 to 23.8 cells/well. Moreover, a single non-adherent GSC either remained quiescent or divided into two cells in four-seven days. The stem cell identity of GSCs was further verified by the expression of nestin or glial fibrillary acidic protein. Of the two GSC lines that were injected in immunodeficient mice, only one line formed a tumor in two months. The protein levels of NOTCH1 and platelet derived growth factor receptor alpha positively correlated with the responsiveness of GSCs to γ-secretase inhibitor IX or imatinib, two compounds that inhibit these two proteins, respectively. Furthermore, a combination of temozolomide and a connexin 43 inhibitor robustly inhibited the growth of GSCs. Collectively, our results demonstrate that patient-derived GSCs exhibit different growth rates in culture, possess differential capabilities to form a tumor, and have varied responses to targeted therapies. Our findings underscore the importance of patient-derived GSCs in glioblastoma research and therapeutic development.
Fund Managers Under Pressure: Rationale and Determinants of Secondary Buyouts

The fastest growing segment of private equity (PE) deals is secondary buyouts (SBOs)—sales from one PE fund to another. Using a comprehensive sample of leveraged buyouts, we investigate whether SBOs are value-maximizing, or reflect opportunistic behavior. To proxy for adverse incentives, we develop buy and sell pressure indexes based on how close PE funds are to the end of their investment period or lifetime, their unused capital, reputation, deal activity, and fundraising frequency. We report that funds under pressure engage more in SBOs. Pressured buyers pay higher multiples, use less leverage, and syndicate less suggesting that their motive is to spend equity. Pressured sellers exit at lower multiples and have shorter holding periods. When pressured counterparties meet, deal multiples depend on differential bargaining power. Moreover, funds that invested under pressure underperform.
Conjunction in the Language of Emotions.

Oatley and Johnson-Laird (1987) have proposed a cognitive theory of emotion. According to this theory, there are five basic emotions. A major prediction of the theory is that it should permit satisfactory definitions for all the emotion words in a language, and this was essayed for the English language by Johnson-Laird and Oatley (1989). The theory proposes that only one emotional state can be operative at a time, and therefore words referring to mixed emotions were defined by Johnson-Laird and Oatley as disjunctions of basic emotions. Two experiments are reported which com pared these disjunctive definitions with conjunctive definitions (i.e. definitions inconsistent with the theory). For a number of words, conjunctive definitions tended to be preferred. This tendency was increased when the disjunctions and conjunctions were made more explicit. This finding sug gests that Oatley and Johnson-Laird's theory should be modified so as to embrace the conjunction of emotion. That is, it should allow that two or more emotions can be exnerienced in parallel.
Participants’ Perceptions of Worksite Health-Promotion Educational Activities

ABSTRACT Adults spend a significant amount of time at work making the worksite a convenient venue for participation in health-promotion activities. This research project examined participants’ perceptions of gaining knowledge and changing health behavior practices as a result of knowledge gained through participation in health-promotion activities provided at the worksite. The worksite health-promotion activities were offered as a result of an innovative collaboration effort between nursing faculty in an academic setting and a community partner in the private sector. The findings demonstrate that participation in health-promotion activities at the worksite can result in increased knowledge and changes in health behavior practices as a result of knowledge gained.
Hematological Changes in Patients Undergoing Coronary Artery Bypass Surgery: a Prospective Study

Objectives: Removal of pro inflammatory stimuli after CABG, wound closure and the regenerative ability of the bone marrow will ensure a gradual recovery of hematological parameters. The aim of this study was to assess the hematological changes after CABG. Materials and Methods: A prospective cohort study included 164 consecutive patients undergoing on pump CABG surgery between January 2012 and January 2013. Patients with primary hematologic disease, emergent or urgent CABG and off-pump CABG were not included. A time line protocol was employed. Results: All patients survived surgery. Average values of erythrocytes, hemoglobin and hematocrit declined, to reach lower values on day 3 after surgery (-33.6 %, -33.1 %, -32.6 % versus preoperative value, p<0.001) and then gradually increased to reach normal values after one month and the preoperative values after three months. The average values of leukocytes and neutrophils increased rapidly to achieve the highest value on day 2, while the average value of lymphocytes decreased quickly to achieve lower value on day 1 after surgery (+74.7 %, +127.1 %, -52.4 % respectively from the preoperative value, p<0.001). The average platelet count decreased to the lowest value on day 2 after surgery (-26.4 % from the preoperative value, p<0.001), after which gradually increased up to +100.8 % of preoperative value on day 14 (p<0.001) and then gradually decreased to reach normal values on day 21 and preoperative values after three months. Conclusions: Average values of the three peripheral blood cells parameters undergo important changes after CABG, but not life threatening, and regain normal and preoperative values after 1-3 months after surgery.
The Long Non-Coding RNAs in Neurodegenerative Diseases: Novel Mechanisms of Pathogenesis.

BACKGROUND Long-non-coding RNAs (lncRNAs), RNA molecules longer than 200 nucleotides, have been involved in several biological processes and in a growing number of diseases, controlling gene transcription, pre-mRNA processing, the transport of mature mRNAs to specific cellular compartments, the regulation of mRNA stability, protein translation and turnover. The fundamental role of lncRNAs in central nervous system (CNS) is becoming increasingly evident. LncRNAs are abundantly expressed in mammalian CNS in a specific spatio-temporal manner allowing a quick response to environmental/molecular changes. METHODS This article reviews the biology and mechanisms of action of lncRNAs underlying their potential role in CNS and in some neurodegenerative diseases. RESULTS an increasing number of studies report on lncRNAs involvement in different molecular mechanisms of gene expression modulation in CNS, from neural stem cell differentiation mainly by chromatin remodeling, to control of neuronal activities. More recently, lncRNAs have been implicated in neurodegenerative diseases, including Alzheimer's Disease, where the role of BACE1-AS lncRNA has been widely defined. BACE1-AS levels are up-regulated in AD brains where BACE1-AS acts by stabilizing BACE1 mRNA thereby increasing BACE1 protein content and Aβ42 formation. In Frontotemporal dementia and Amyotrophic lateral sclerosis the lncRNAs NEAT1_2 and MALAT1 co-localize at nuclear paraspeckles with TDP-43 and FUS proteins and their binding to TDP-43 is markedly increased in affected brains. In Parkinson's Disease the lncRNA UCHL1-AS1 acts by directly promoting translation of UCHL1 protein leading to perturbation of the ubiquitin-proteasome system. Different lncRNAs, such as HTT-AS, BDNF-AS and HAR1, were found to be dysregulated in their expression also in Huntington's Disease. In Fragile X syndrome (FXS) and Fragile X tremor/ataxia syndrome (FXTAS) patients, the presence of CGG repeats expansion alters the expression of the lncRNAs FMR1-AS1 and FMR6. Interestingly, they are expressed in peripheral blood leukocytes, suggesting these lncRNAs may represent biomarkers for FXS/FXTAS early detection and therapy. Finally, the identification of the antisense RNAs SCAANT1-AS and ATXN8OS in spinocerebellar ataxia 7 and 8, respectively, suggests that very different mechanisms of action driven by lncRNAs may trigger neurodegeneration in these disorders. CONCLUSION The emerging role of lncRNAs in neurodegenerative diseases suggests that their dysregulation could trigger neuronal death via still unexplored RNA-based regulatory mechanisms which deserve further investigation. The evaluation of their diagnostic significance and therapeutic potential could also address the setting up of novel treatments in diseases where no cure is available to date.
Who Brings in the Fish? The Relative Contribution of Small-Scale and Industrial Fisheries to Food Security in Southeast Asia

Amidst overexploited fisheries and further climate related declines projected in tropical fisheries, marine dependent small-scale fishers in Southeast Asia face an uncertain future. Yet, small-scale fishers are seldom explicitly considered in regional fisheries management and their contribution to national fish supply tends to be greatly under-estimated compared to industrial fisheries. Lack of knowledge about the small-scale sector jeopardises informed decision-making for sustainable ecosystem based fisheries planning and social development. We fill this knowledge gap by applying reconstructed marine fish catch statistics from Cambodia, Malaysia, Thailand, and Vietnam – countries of the Gulf of Thailand - from 1950 to 2013 to assess the relative contribution of small-scale and industrial fisheries to national food security. Reconstructed catches quantify reported and unreported fish catch from industrial, small-scale, and recreational fishing. We then conduct a comparative analysis of the degree to which the industrial and small-scale sectors support food security, by converting total catch to the portion that is kept for human consumption and that which is diverted to fishmeal for animal feed or other purposes. Total reconstructed marine fish catch from the four Southeast Asian countries totalled 282 million t from 1950 to 2013, with small-scale sector catches being underestimated by an average of around 2 times. When the amount of fish that is diverted to fishmeal is omitted, small-scale fishers contribute more food fish for humans than do industrial fisheries for much of the period until 2000. These results encourage regional fisheries management to be cognisant of small-scale fisheries as a pillar of socio-economic well-being for coastal communities.
3LC: Lightweight and Effective Traffic Compression for Distributed Machine Learning

The performance and efficiency of distributed machine learning (ML) depends significantly on how long it takes for nodes to exchange state changes. Overly-aggressive attempts to reduce communication often sacrifice final model accuracy and necessitate additional ML techniques to compensate for this loss, limiting their generality. Some attempts to reduce communication incur high computation overhead, which makes their performance benefits visible only over slow networks. We present 3LC, a lossy compression scheme for state change traffic that strikes balance between multiple goals: traffic reduction, accuracy, computation overhead, and generality. It combines three new techniques---3-value quantization with sparsity multiplication, quartic encoding, and zero-run encoding---to leverage strengths of quantization and sparsification techniques and avoid their drawbacks. It achieves a data compression ratio of up to 39--107X, almost the same test accuracy of trained models, and high compression speed. Distributed ML frameworks can employ 3LC without modifications to existing ML algorithms. Our experiments show that 3LC reduces wall-clock training time of ResNet-110--based image classifiers for CIFAR-10 on a 10-GPU cluster by up to 16--23X compared to TensorFlow's baseline design.