Miracle-dz/UniFAR-FTUs huggingface dataset:
A minimum mean-squared error interpretation of residual ISI channel shortening for discrete multitone transceivers

P.J.W. Melsa et al. (see IEEE Transactions on Communications, vol.44, p.1662-72, 1996) presented a channel shortening technique for discrete multitone transceivers that reduces intersymbol interference (ISI) by forcing the effective channel's impulse response to lie within a window of v+1 consecutive samples. G. Arslan et al. (see IEEE International Conference on Acoustic Speech and Signal Processing (ICASSP), p.2965-8, 2000) claim that although this method is intuitive, no previous study has been made on its optimality. They comment on its optimality by simulation. We demonstrate that Melsa's approach is in fact theoretically equivalent to a minimum mean-squared error (MMSE) solution to the channel-shortening problem. As a corollary to this we are afforded an insight into MMSE channel shortening as originally proposed by D.D. Falconer and F.R. Magee (see Bell Systems Technical Journal, p.1541-62, 1973). Previously, it has not been intuitive as to why the desired impulse response (DIR) should be made adaptive in this approach. Our result demonstrates that allowing DIR adaptation achieves a minimisation of the effective impulse response energy outside the desired window of v samples.
Minimum Audible Angle, Just Noticeable Interaural Differences and Speech Intelligibility with Bilateral Cochlear Implants Using Clinical Speech Processors

Sound localization and speech intelligibility were assessed in 5 patients implanted bilaterally with Medel C40+ or Medel C40 cochlear implant (CI) systems. The minimum audible angle (MAA) around the head in the horizontal plane was assessed in patients with bilateral CI using white noise bursts of 1000 ms duration presented from a loudspeaker mounted on a rotating boom and compared with the MAA of age-matched normal hearing controls. Spatial discrimination was found to be good in front and in the back of the head with near-normal MAA values (patients: 3–8°, controls: 1–4°). In contrast, poor performance on the sides was found (patients: 30 to over 45°, controls 7–10°). Bilateral CI significantly improved spatial discrimination in front for all patients, when compared with the use of either CI alone. Just noticeable differences (JNDs) in interaural intensity and time were assessed using white noise bursts (1000 ms duration; 50 ms linear ramp). In addition, interaural time JNDs were assessed using click trains (800 ms duration, 40 µs clicks, 50 Hz) and noise bursts in which either only the envelope or only the fine structure was shifted in time. In comparison with normal hearing controls, patients with bilateral CI showed near-normal interaural intensity JNDs but substantially poorer interaural time JNDs depending on the type of stimulus. In contrast to envelope onset/offset cues, interaural fine structure time differences were not perceived by the patients using CI systems employing the continuous interleaved sampling strategy without synchronization between their pulse stimulation times. Speech intelligibility in quiet and CCITT noise from the side (±90°) was assessed using the German HSM sentence test and was significantly better when using bilateral CI in comparison with either unilateral CI, mainly due to a head shadow effect. These favorable results are in agreement with the patients’ subjective experiences assessed with a questionnaire and support the use of bilateral CI.
THE MOTIVATIONS TO ENTER TEACHING BY AGE RELATED CAREER STAGE AND CERTIFICATION PATH

In this research I compare the motivations to enter the teaching occupation among 49 novice teachers who participated in traditional and alternative preparation programs to explore the influence of age and career stage on the decision making process. Early career entrants in both groups were more likely to cite the subject specialty as a reason to enter the occupation but only mid-career traditionally certified teachers included social concerns as a motivator. Overall, twice as many alternatively certified teachers cited the opportunity for a stable career as a motivator than did traditionally certified teachers.
The G protein-activating peptide, mastoparan, and the synthetic NH2- terminal ARF peptide, ARFp13, inhibit in vitro Golgi transport by irreversibly damaging membranes

Mastoparan is a cationic amphipathetic peptide that activates trimeric G proteins, and increases binding of the coat protein beta-COP to Golgi membranes. ARFp13 is a cationic amphipathic peptide that is a putative specific inhibitor of ARF function, and inhibits coat protein binding to Golgi membranes. Using a combination of high resolution, three- dimensional electron microscopy and cell-free Golgi transport assays, we show that both of these peptides inhibit in vitro Golgi transport, not by interfering in the normal functioning of GTP-binding proteins, but by damaging membranes. Inhibition of transport is correlated with inhibition of nucleotide sugar uptake and protein glycoslation, a decrease in the fraction of Golgi cisternae exhibiting normal morphology, and a decrease in the density of Golgi-coated buds and vesicles. At peptide concentrations near the IC50 for transport, those cisternae with apparently normal morphology had a higher steady state level of coated buds and vesicles. Kinetic analysis suggests that this increase in density was due to a decrease in the rate of vesicle fission. Pertussis toxin treatment of the membranes appeared to increase the rate of vesicle formation, but did not prevent the membrane damage induced by mastoparan. We conclude that ARFp13 is not a specific inhibitor of ARF function, as originally proposed, and that surface active peptides, such as mastoparan, have the potential for introducing artifacts that complicate the analysis of trimeric G protein involvement in regulation of Golgi vesicle dynamics.
Psychiatry in Africa: Special Problems and Unique Features

continent of Africa was under colonial rule (with the exception of Egypt, Liberia, Ethiopia and South Africa); but a short ten years later almost all countries had achieved independence (Wiedner, 1964). Carothers’ review therefore reflects the attitudes of the final stages of the colonial occupation which are perhaps best epitomized in his notorious conclusion that Africans behaved very much like lobotomized Europeans (Carothers, 1951). Since Carothers, the most comprehensive reviews of psychiatry in Africa are to be found in the Proceedings of the First, Second and Third Pan-African conferences held in Abeokuta, Nigeria (1961); Dakar, Senegal (1968); and Khartoum, Sudan (1972)’ respectively. These conferences of the sixties represent a kind of Janus-headed psychiatric stock-taking, a retrospective and prospective at the time of the transfer of colonial power. They attracted major academicians, researchers, clinicians and mental health workers from many parts of Africa (Francophone and Anglophone, Islamic and Christian) as well as Europe, United States and Canada. They included important reviews of psychiatric disorders associated with organic factors such
Long-Term Function of Islets Encapsulated in a Redesigned Alginate Microcapsule Construct in Omentum Pouches of Immune-Competent Diabetic Rats

Objective Our study aim was to determine encapsulated islet graft viability in an omentum pouch and the effect of fibroblast growth factor 1 (FGF-1) released from our redesigned alginate microcapsules on the function of the graft. Methods Isolated rat islets were encapsulated in an inner core made with 1.5% low-viscosity–high-mannuronic-acid alginate followed by an external layer made with 1.25% low-viscosity high-guluronic acid alginate with or without FGF-1, in microcapsules measuring 300 to 400 µm in diameter. The 2 alginate layers were separated by a perm-selective membrane made with 0.1% poly-l-ornithine, and the inner low-viscosity–high-mannuronic-acid core was partially chelated using 55 mM sodium citrate for 2 minutes. Results A marginal mass of encapsulated islet allografts (∼2000 islets/kg) in streptozotocin-diabetic Lewis rats caused significant reduction in blood glucose levels similar to the effect observed with encapsulated islet isografts. Transplantation of alloislets coencapsulated with FGF-1 did not result in better glycemic control, but induced greater body weight maintenance in transplant recipients compared with those that received only alloislets. Histological examination of the retrieved tissue demonstrated morphologically and functionally intact islets in the microcapsules, with no signs of fibrosis. Conclusions We conclude that the omentum is a viable site for encapsulated islet transplantation.
Transmembrane pH gradient and membrane potential in Clostridium acetobutylicum during growth under acetogenic and solventogenic conditions

The proton motive force and its electrical and chemical components were determined in Clostridium acetobutylicum, grown in a phosphate-limited chemostat, using [14C]dimethyloxazolidinedione and [14C]benzoic acid as transmembrane pH gradient (delta pH) probes and [14C]triphenylmethylphosphonium as a membrane potential (delta psi) indicator. The cells maintained an internal-alkaline pH gradient of approximately 0.2 at pH 6.5 and 1.5 at pH 4.5. The delta pH was essentially constant between pH 6.5 and 5.5 but increased considerably at lower extracellular pH values down to 4.5. Hence, the intracellular pH fell from 6.7 to 6.0 as the external pH was lowered from 6.5 to 5.5 but did not decrease further when the external pH was decreased to 4.5. The transmembrane electrical potential decreased as the external pH decreased. At pH 6.5, delta psi was approximately -90 mV, whereas no negative delta psi was detectable at pH 4.5. The proton motive force was calculated to be -106 mV at pH 6.5 and -102 mV at pH 4.5. The ability to maintain a high internal pH at a low extracellular pH suggests that C. acetobutylicum has an efficient deacidification mechanism which expresses itself through the production of neutral solvents.
Measurement of external ischial tuberosity width for young Taiwanese subjects

Introduction: People lead a sedentary lifestyle throughout most of the day because of work and living activities. In addition to the lumbar spine, a crucial factor for designing seats (cushions) is buttock-seat (cushion) contact. Specifically, seated pressure is the most frequently studied aspect (Dunk and Callagham, 2005). Chairs with different functions may result in various types of seated pressure distribution, which is mainly influenced by the value of seated pressure between the ischial tuberosities (ITs) of the human pelvis and the seat surface. An understanding of external ischial tuberosity width (EITW), which represents the width of the ITs covered in fat pads, has practical contributions to the design of seats and cushions.
Profiling Plasma Peptides for the Identification of Potential Ageing Biomarkers in Chinese Han Adults

Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.
Profiles in Driver Distraction: Effects of Cell Phone Conversations on Younger and Older Drivers

Our research examined the effects of hands-free cell phone conversations on simulated driving. We found that driving performance of both younger and older adults was influenced by cell phone conversations. Compared with single-task (i.e., driving-only) conditions, when drivers used cell phones their reactions were 18% slower, their following distance was 12% greater, and they took 17% longer to recover the speed that was lost following braking. There was also a twofold increase in the number of rear-end collisions when drivers were conversing on a cell phone. These cell-phone-induced effects were equivalent for younger and older adults, suggesting that older adults do not suffer a significantly greater penalty for talking on a cell phone while driving than compared with their younger counterparts. Interestingly, the net effect of having younger drivers converse on a cell phone was to make their average reactions equivalent to those of older drivers who were not using a cell phone. Actual or potential applications of this research include providing guidance for recommendations and regulations concerning the use of mobile technology while driving.
Bone Metastases: Molecular Mechanisms and Novel Therapeutic Interventions

It has been long recognized that skeleton represents one of the most favored metastatic sites for common cancers like breast and prostate. During the last decade the molecular mechanisms that are responsible for the development of bone metastasis have been gradually illuminated. It appears that the bone microenvironment has a pivotal role in this process. Metastatic tumor cells interact with bone triggering a cascade of molecular events that produce osteolytic and/or osteoblastic phenomena. In this review, we summarize and discuss the most significant factors and signaling pathways implicated in bone colonization. Moreover, based on the recent literature and data, we foresee the need for designing novel agents that will efficiently disrupt these interactions among cancer cells and bone microenvironment, bringing hope for more effective treatments. © 2010 Wiley Periodicals, Inc. Med Res Rev, 32, No. 3, 611–636, 2012
The Full-Length Protein Encoded by Human Cytomegalovirus Gene UL117 Is Required for the Proper Maturation of Viral Replication Compartments

ABSTRACT Previously, two large-scale mutagenic analyses showed that mutations in the human cytomegalovirus (HCMV) gene UL117 resulted in a defect in virus growth in fibroblasts. Early transcriptional analyses have revealed several mRNAs from the UL119-UL115 region; however, specific transcripts encoding UL117-related proteins have not been identified. In this study, we identified two novel transcripts arising from the UL117 gene locus, and we reported that the UL117 open reading frame encoded the full-length protein pUL117 (45 kDa) and the shorter isoform pUL117.5 (35 kDa) as the result of translation initiation at alternative in-frame ATGs. Both proteins were expressed with early kinetics, but pUL117 accumulated at a lower abundance relative to that of pUL117.5. During HCMV infection, both proteins localized predominantly to the nucleus, and the major fraction of pUL117 localized in viral nuclear replication compartments. We constructed mutant HCMV viruses in which the entire UL117 coding sequence was deleted or the expression of pUL117 was specifically abrogated. The growth of mutant viruses was significantly attenuated, indicating that pUL117 was required for efficient virus infection in fibroblasts. Cells infected with the pUL117-deficient mutant virus accumulated representative viral immediate-early proteins and early proteins normally. In the absence of pUL117, the accumulation of replicating viral DNA was reduced by no more than twofold at early times and was indistinguishable from that of the wild type at 72 h postinfection. Strikingly, there was a 12- to 24-h delay in the development of nuclear replication compartments and a marked delay in the expression of late viral proteins. We conclude that pUL117 acts to promote the development of nuclear replication compartments to facilitate viral growth.
eWOM as Source of Influence: The Impact of Participation in eWOM and Perceived Source Trustworthiness on Decision Making

Word of mouth (WOM) is an important information source for consumers. Previous researchers have shown it is more credible and persuasive than commercial information. The development of new electronic media has increased the importance of this interpersonal influence (referred to as eWOM). The degree of participation in eWOM varies among individuals. Participation in eWOM is composed of two behaviors: opinion-seeking behavior and opinion-giving behavior. Several antecedents of participation in eWOM have been previously studied, but the consequences of participating are mostly unknown. This article proposes and tests a theoretical model that analyzes the extent to which participation in eWOM can be considered a determinant of eWOM influence on decision making at an individual level, and it includes perceived source trustworthiness as a mediator. Both opinion-seeking and opinion-giving behaviors seem to predict eWOM influence on decision making. Results also indicate that perceived source trustworthiness partially mediates the relationship between opinion-seeking behavior and eWOM influence on decision making. In contrast, perceived source trustworthiness totally mediates the relationship between opinion-giving behavior and eWOM influence on decision making. Therefore, perceived source trustworthiness arises as a key factor of eWOM influence on decision making for those who usually give opinions.
A Longitudinal Study of the Relationships Among Self-Monitoring, Authentic Leadership, and Perceptions of Leadership

There is little research examining variability in leadership outcomes over time as a function of individual differences. The present study investigates how the extent to which individuals are perceived as leaders varies over time, with self-monitoring and authentic leadership as predictors. Hierarchical linear modeling analyses found that change in the extent to which individuals were perceived to be leaders by others varied across individuals, but this variability was not due to individuals' self-monitoring, authentic leadership, or declining interrater reliability. It was also found that individuals' overestimation of themselves as leaders increased over time. Finally, an initial measure of authentic leadership was developed.
Farmers’ motivations, risk perceptions and risk management strategies in a developing economy: Bangladesh experience

Aquaculture farmers’ risk perceptions and risk management strategies have still received little attention in agricultural research. Therefore, an exploratory study has been undertaken to provide empirical insight into Bangladeshi coastal shrimp farmers’ risk perceptions and risk management responses. Data from our study show that 95% of farmers have no formal training in shrimp aquaculture. Shrimp farmers’ cooperative societies operate in only 13.3% of the studied areas and only 15% of shrimp farmers are involved with these cooperative societies. The results reveal that shrimp diseases, price and availability of quality shrimp seeds, exploitation by intermediaries and uncertainty about the future demand for shrimp in foreign markets are perceived as the most important sources of risk. On the other hand, prevention of disease, timely supply of shrimp seeds, elimination of middlemen from the supply chain and farm management training are considered among the best methods to manage the risks in the shrimp‐farming business. We also observe some disparities in farmers’ perceptions. For instance, farmers mentioned that removal of influence of middlemen from supply chain is essential for the betterment of their business. However, they did not consider market monitoring, direct contract with processors and improved marketing facilities as important risk management strategies, although these factors play a significant role in reducing the influence of intermediaries and private money lenders.
Perception of Physical Attractiveness Influenced by Similarity of Attitudes

59 men and women, 20 to 30 yr. old, rated 15 items about everyday life on Likert scales and 5 wk. later rated a male's photograph for attractiveness and similarity. A target person who appeared verbally similar to the subjects was rated more physically attractive than a dissimilar target. No negative effect of dissimilarity was noted.
Expression of Genes Involved in Anthocyanin Biosynthesis in Relation to Anthocyanin, Proanthocyanidin, and Flavonol Levels during Bilberry Fruit Development1

The production of anthocyanins in fruit tissues is highly controlled at the developmental level. We have studied the expression of flavonoid biosynthesis genes during the development of bilberry (Vaccinium myrtillus) fruit in relation to the accumulation of anthocyanins, proanthocyanidins, and flavonols in wild berries and in color mutants of bilberry. The cDNA fragments of five genes from the flavonoid pathway, phenylalanine ammonia-lyase, chalcone synthase, flavanone 3-hydroxylase, dihydroflavonol 4-reductase, and anthocyanidin synthase, were isolated from bilberry using the polymerase chain reaction technique, sequenced, and labeled with a digoxigenin-dUTP label. These homologous probes were used for determining the expression of the flavonoid pathway genes in bilberries. The contents of anthocyanins, proanthocyanidins, and flavonols in ripening bilberries were analyzed with high-performance liquid chromatography-diode array detector and were identified using a mass spectrometry interface. Our results demonstrate a correlation between anthocyanin accumulation and expression of the flavonoid pathway genes during the ripening of berries. At the early stages of berry development, procyanidins and quercetin were the major flavonoids, but the levels decreased dramatically during the progress of ripening. During the later stages of ripening, the content of anthocyanins increased strongly and they were the major flavonoids in the ripe berry. The expression of flavonoid pathway genes in the color mutants of bilberry was reduced. A connection between flavonol and anthocyanin synthesis in bilberry was detected in this study and also in previous data collected from flavonol and anthocyanin analyses from other fruits. In accordance with this, models for the connection between flavonol and anthocyanin syntheses in fruit tissues are presented.