Miracle-dz/UniFAR-FTUs huggingface dataset:
Martorell hypertensive ischemic leg ulcer: a model of ischemic subcutaneous arteriolosclerosis.

OBJECTIVES To better define the diagnosis and treatment of Martorell hypertensive ischemic leg ulcer (HYTILU) and to compare Martorell HYTILU with calciphylaxis (calcific uremic arteriolopathy) and nonuremic forms of calciphylaxis. DESIGN Retrospective study from 1999 through 2007. SETTING Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland. PARTICIPANTS Of 330 patients with leg ulcers, 31 had a clinical diagnosis of Martorell HYTILU confirmed by dermatopathologic examination. MAIN OUTCOME MEASURES Clinical features, suspected diagnosis at initial presentation, cardiovascular risk factors, findings from vascular examination and histologic analysis, specific medical and surgical management, and outcome. RESULTS Of the 31 patients, all presented with 1 or multiple painful necrotic skin ulcers on the laterodorsal part of the leg, with bilateral involvement in 16 of 31 cases (52%), and 16 were referred with suspected pyoderma gangrenosum. All patients had arterial hypertension, and 18 (58%) had diabetes. All patients had subcutaneous stenotic arteriolosclerosis on histologic analysis, with medial calcification in 22 of 31 of cases (71%). Martorell HYTILU, calciphylaxis, and nonuremic forms of calciphylaxis shared identical histologic features. Of the 31 patients, 29 (94%) were successfully treated with surgical debridement and split-thickness skin grafting. Three patients (9%) died of sepsis, 2 of whom were undergoing immunosuppressive treatment for wrongly diagnosed pyoderma gangrenosum. CONCLUSIONS Ischemic subcutaneous arteriolosclerosis is the hallmark of Martorell HYTILU, calciphylaxis, and the nonuremic forms of calciphylaxis. All patients are hypertensive and approximately 60% are diabetic. Martorell HYTILU can easily be confused with pyoderma gangrenosum, which can be detrimental, since the 2 diseases require a completely different treatment strategy.
Analgesic action of suspended moxibustion in rats with chronic visceral hyperalgesia correlates with enkephalins in the spinal cord

Rats that modeled chronic visceral hyperalgesia received suspended moxibustion at bilateral Tianshu (ST25) and Shangjuxu (ST37) once daily over a period of 7 days. Results show that suspended moxibustion significantly depressed abdominal withdrawal reflex scores and increased enkephalin concentration in the spinal cord. The experimental findings suggest that spinal enkephalins contributed to the analgesic effect of suspended moxibustion in rats with chronic visceral hyperalgesia.
Phenological and Geographical Shifts Have Interactive Effects on Migratory Bird Populations

For many taxa, ranges are shifting toward the poles and the timing of seasonal reproduction is advancing in response to climate change. For migratory birds, changes such as these could produce particularly strong impacts because of their potential to affect migratory timing and distance. Due to the relatively complex life histories of migratory species, however, it is difficult to intuit exactly what these impacts will be. Here, we develop a general population model for a long-distance migrant, introducing a framework for understanding the potential implications of changes in both phenology and migratory distance for bird abundances. We find that population sizes may increase with either shorter or longer migratory distances, depending on the nature of any concurrent phenological changes. This interaction between timing and distance suggests a need to consider multiple potential responses to climate change simultaneously in order to understand the overall impact of climate change on migratory populations. Our results reveal a degree of variability in the qualitative nature of this phenology-distance interaction, suggesting a possible explanation for observed variation in how migratory birds have already responded to climate change.
Validity and reliability of the VRAG in a forensic psychiatric medium security population in Flanders

ABSTRACT Since the development of the Violence Risk Appraisal Guide (VRAG), one of the most widely used actuarial risk assessment instruments, numerous replication studies have shown its usefulness in predicting (violent) recidivism among various offender populations. It is not clear, however, whether these findings can be generalized to forensic psychiatric patients admitted to a medium security forensic psychiatric unit in the Flemish part of Belgium. Therefore, the main aim of this study was to test the predictive validity and reliability of the VRAG in a sample of 191 Flemish medium security patients. The mean follow-up period was 2.4 years. Contrary to the expectations, the VRAG was unable to significantly predict any kind of outcome. Possible explanations are discussed and further research with the VRAG in Flanders, and its recently revised version, is recommended.
Bridge the Gap between the Lorenz System and the Chen System

This paper introduces a unified chaotic system that contains the Lorenz and the Chen systems as two dual systems at the two extremes of its parameter spectrum. The new system represents the continued transition from the Lorenz to the Chen system and is chaotic over the entire spectrum of the key system parameter. Dynamical behaviors of the unified system are investigated in somewhat detail.
Predictors of Stress among Parents of Preschool Aged Children with Autism Spectrum Disorders

The present study examined factors that contributed to the perceived family stress and disability stress of 72 parents of preschool aged children with Autism Spectrum Disorder (ASD). Parents reported on their self-efficacy, belief in the efficacy of their child’s intervention approach, perception of child progress, knowledge of autism, and five indicators of program satisfaction: cultural sensitivity, access, appropriateness, participation in treatment, outcome and demographic/treatment specific characteristics. The best set of predictors for perceived stress included parental efficacy, belief in the efficacy of intervention, satisfaction with the access to services, as well as level of satisfaction with those services, and whether or not parents were participating in a live support group or using respite services. The best predictors for disability stress were parental self-efficacy, program satisfaction (particularly the appropriateness of services), and if parents did not participate in a live support group. The discussion considers the implications for program development and implementation based on these findings.
Academic Productivity and Its Relationship to Physician Salaries in the University of California Healthcare System

Objectives To evaluate whether physicians with higher academic productivity, as measured by the number of publications in Scopus and the Scopus Hirsch index (h-index), earn higher salaries. Methods This was a cross-sectional study. Participants were ophthalmologists, otolaryngologists, neurosurgeons, and neurologists classified as “top earners” (>$100,000 annually) within the University of California (UC) healthcare system in 2008. Bibliometric searches on Scopus were conducted to retrieve the total number of publications and Hirsch indices (h-index), a measure of academic productivity. The association between the number of publications and h-index on physicians’ total compensation was determined with multivariate regression models after controlling for the four specialties (ophthalmology, otolaryngology, neurosurgery, and neurology), the five institutions (UC San Francisco, UC Los Angeles, UC San Diego, UC Irvine, and UC Davis), and academic rank (assistant professor, associate professor, and professor). Results The UC healthcare system departments reported 433 faculty physicians among the four specialties, with 71.6% (n = 310) earning more than $100,000 in 2008 and classifying as top earners. After controlling for the specialty, institution, and ranking, there was a significant association between the number of publications on salary (P < 0.000001). Scopus number of publications and h-index were correlated (P < 0.001). Scopus h-index was of borderline significance in predicting physician salary (P = 0.12). Physicians with higher Scopus publications had higher total salaries across all four specialties. Every 10 publications were associated with a 2.40% increase in total salary after controlling for specialty, institution, rank, and chair. Conclusions Ophthalmologists, otolaryngologists, neurosurgeons, and neurologists in the UC healthcare system who are more academically productive receive greater remuneration.
The social bordering of lifestyle sports: inclusive principles, exclusive reality

ABSTRACT Lifestyle sports are created and maintained through global youth cultural representations disseminated by many current media channels. Lifestyle sports attract young people due to their images of sociality, joyful creativity, speed and excitement, urban exoticism and their subcultural distinction from mainstream sports. This distinction is maintained with claims of social and cultural openness. Through a case analysis conducted for a research project we asked: How open are lifestyle sports communities and to whom? Who can take part in the subcultural world of lifestyle sports? What kinds of structural or personal attributes connected with individuals restrict certain young people's participation in this world? The research material consists of qualitative and quantitative data collected among skateboarding, longboarding, parkour and roller derby practitioners in Finland. Seeking answers brings researchers to the classical sociological background variables and their intersections: gender, ethnicity, sexual orientation, disability and socioeconomic status. In lifestyle sports, these categorisations are linked with physical skills as subcultural symbolic capital, which is central in the exclusive and inclusive practices in lifestyle sports communities. Despite the inclusive principles that lifestyle sports practitioners emphasise, the ideal lifestyle sport practitioner seems to be represented by hegemonic masculinity, muscular strength and agility symbolising sporting abilities.
Playing Subaltern

The postcolonial has still remained on the margins of Game Studies, which has now incorporated at length, contemporary debates of race, gender, and other areas that challenge the canon. It is difficult to believe, however, that it has not defined the way in which video games are perceived; the effect, it can be argued, is subtle. For the millions of Indians playing games such as Empire: Total War or East India Company, their encounter with colonial history is direct and unavoidable, especially given the pervasiveness of postcolonial reactions in everything from academia to day-to-day conversation around them. The ways in which games construct conceptions of spatiality, political systems, ethics, and society are often deeply imbued with a notion of the colonial and therefore also with the questioning of colonialism. This article aims to examine the complexities that the postcolonial undertones in video games bring to the ways in which we read them.
Recovery of rat submandibular salivary gland function following removal of obstruction: a sialometrical and sialochemical study

Functional recovery of the rat submandibular gland following ligation of the main excretory duct was examined. Rat submandibular glands were ligated for 1, 4 and 8 weeks using a micro‐clip with a plastic tube. Micro‐clips were removed and glands were allowed to recover for periods of 8, 16 and 24 weeks. Submandibular glands were stimulated with autonomimetic drugs (methacholine and isoprenaline) and salivas were collected from atrophic or de‐ligated and contralateral control glands. Glands recovered almost full size (92% of control gland) following 24 weeks of de‐ligation. Saliva volume secreted by ligated/de‐ligated (RSM) and control (LSM) glands were similar with different doses of agonists. Protein output expressed per gram of tissue wet weight was similar from both ligated/de‐ligated and control glands with all doses of agonist. Sodium and chloride levels were higher from de‐ligated glands than contralateral control glands. Protein electrophoresis showed similar profiles of salivary proteins in all samples with some minor differences. Acinar cells in de‐ligated glands showed a normal morphology, as indicated by light microscopy, whilst granular ductal cells were fewer and contained fewer secretory granules. Sodium potassium ATPase staining of striated ducts in de‐ligated glands was similar to that of control glands. It can be concluded that rat submandibular glands can regenerate following severe atrophy and secrete normal amounts of saliva containing broadly a full profile of secretory proteins. In contrast to acinar cells, ductal cells appear not to recover full function.
Metabolomic insights into the intricate gut microbial–host interaction in the development of obesity and type 2 diabetes

Gut microbiota has recently been proposed as a crucial environmental factor in the development of metabolic diseases such as obesity and type 2 diabetes, mainly due to its contribution in the modulation of several processes including host energy metabolism, gut epithelial permeability, gut peptide hormone secretion, and host inflammatory state. Since the symbiotic interaction between the gut microbiota and the host is essentially reflected in specific metabolic signatures, much expectation is placed on the application of metabolomic approaches to unveil the key mechanisms linking the gut microbiota composition and activity with disease development. The present review aims to summarize the gut microbial–host co-metabolites identified so far by targeted and untargeted metabolomic studies in humans, in association with impaired glucose homeostasis and/or obesity. An alteration of the co-metabolism of bile acids, branched fatty acids, choline, vitamins (i.e., niacin), purines, and phenolic compounds has been associated so far with the obese or diabese phenotype, in respect to healthy controls. Furthermore, anti-diabetic treatments such as metformin and sulfonylurea have been observed to modulate the gut microbiota or at least their metabolic profiles, thereby potentially affecting insulin resistance through indirect mechanisms still unknown. Despite the scarcity of the metabolomic studies currently available on the microbial–host crosstalk, the data-driven results largely confirmed findings independently obtained from in vitro and animal model studies, putting forward the mechanisms underlying the implication of a dysfunctional gut microbiota in the development of metabolic disorders.
The Importance of Play in Promoting Healthy Child Development and Maintaining Strong Parent-Child Bond: Focus on Children in Poverty

Play is essential to the social, emotional, cognitive, and physical well-being of children beginning in early childhood. It is a natural tool for children to develop resiliency as they learn to cooperate, overcome challenges, and negotiate with others. Play also allows children to be creative. It provides time for parents to be fully engaged with their children, to bond with their children, and to see the world from the perspective of their child. However, children who live in poverty often face socioeconomic obstacles that impede their rights to have playtime, thus affecting their healthy social-emotional development. For children who are underresourced to reach their highest potential, it is essential that parents, educators, and pediatricians recognize the importance of lifelong benefits that children gain from play.
Clofazimine in the treatment of extensively drug-resistant tuberculosis with HIV coinfection in South Africa: a retrospective cohort study.

BACKGROUND Extensively drug-resistant (XDR) tuberculosis (TB) and HIV coinfection is associated with low cure rates and high mortality. Clofazimine has shown activity in vitro against Mycobacterium tuberculosis, but clinical experience with clofazimine in XDR-TB and HIV coinfection is limited. METHODS This was a retrospective cohort study of adult XDR-TB patients in KwaZulu-Natal, South Africa, treated with either a clofazimine- or non-clofazimine-containing XDR-TB treatment regimen. The primary outcome measure was TB culture conversion at 6 months. Survival analysis and multivariate logistic regression compared time to event in different strata and identified risk factors for TB culture conversion. RESULTS Between August 2009 and July 2011, eligible XDR-TB patients (n = 85) were initiated on treatment for XDR-TB. Most patients (86%) were HIV-infected and receiving antiretroviral therapy (90%). Patients receiving a clofazimine-containing regimen (n = 50) had a higher percentage of culture conversion (40%) compared with patients (n = 35) receiving a non-clofazimine regimen (28.6%). On multivariate analysis, there was a 2-fold increase in TB culture conversion at 6 months (hazard rate ratio 2.54, 95% CI 0.99-6.52, P = 0.05) in the group receiving a clofazimine-containing regimen. Adverse effects due to clofazimine were minor and rarely life-threatening. CONCLUSIONS Clofazimine was associated with improved culture conversion in the treatment of XDR-TB/HIV. Adverse effects were minor and non-life-threatening. Based on these preliminary data, further study of clofazimine in XDR-TB/HIV treatment is warranted. Given the present low rates of culture conversion in XDR-TB treatment, we recommend empirical inclusion of clofazimine in treatment regimens for XDR-TB.
Lipid transport in the human newborn. Palmitate and glycerol turnover and the contribution of glycerol to neonatal hepatic glucose output.

Free fatty acid (FFA) transport was measured in 11 and glycerol turnover in 5 newborns with continuous tracer infusion of [1-(13)C]palmitate or [2-(13)C]glycerol, respectively. In addition, simultaneous determination of glucose production in the latter group with [6,6-(2)H(2)]glucose tracer and measurement of the appearance rate of [(13)C]glucose derived from [(13)C]glycerol allowed calculation of gluconeogenesis from glycerol.The average FFA inflow rate was 11.5+/-1.7 mumol kg(-1)min(-1), 2.5-4.5 h after the last feeding, and 16.7+/-2.8 mumol kg(-1)min(-1), 5-12 h after the last meal. These rates are comparable to those found in adults only after 8-16 h and approximately 72 h of fasting, respectively. FFA inflow in the newborn was directly correlated with time of fasting, plasma FFA level, and plasma glycerol level. Palmitate clearance and fractional removal were inversely related to palmitate level. Glycerol flux averaged 4.4+/-0.5 mumol kg(-1)min(-1), a value three- to fourfold that of the postabsorptive adult. Approximately 75% of transported glycerol was converted to glucose and represented 5.0+/-0.6% of hepatic glucose production. Furthermore, there was a direct relationship between glycerol turnover and the fraction of glucose coming from glycerol. Despite the absolutely elevated neonatal FFA and glycerol transport rates, these were quantitatively similar to values found in adults with comparable elevated substrate levels. Furthermore, other similarities with the adult in the relationships between inflow transport and substrate values, and between transport and fractional removal suggest that the regulatory aspects of lipid transport in man are already well developed by the first day of life.
Understanding factors that affect response rates in twitter

In information networks where users send messages to one another, the issue of information overload naturally arises: which are the most important messages? In this paper we study the problem of understanding the importance of messages in Twitter. We approach this problem in two stages. First, we perform an extensive characterization of a very large Twitter dataset which includes all users, social relations, and messages posted from the beginning of the service up to August 2009. We show evidence that information overload is present: users sometimes have to search through hundreds of messages to find those that are interesting to reply or retweet. We then identify factors that influence user response or retweet probability: previous responses to the same tweeter, the tweeter's sending rate, the age and some basic text elements of the tweet. In our second stage, we show that some of these factors can be used to improve the presentation order of tweets to the user. First, by inspecting user activity over time, we construct a simple on-off model of user behavior that allows us to infer when a user is actively using Twitter. Then, we explore two methods from machine learning for ranking tweets: a Naive Bayes predictor and a Support Vector Machine classifier. We show that it is possible to reorder tweets to increase the fraction of replied or retweeted messages appearing in the first p positions of the list by as much as 50-60%.
“Pa Manyen Fanm Nan Konsa”: Intersectionality, Structural Violence, and Vulnerability Before and After Haiti's Earthquake

Abstract:ABSTRACTOn January 12, 2010, an earthquake in Haiti sent shockwaves across the world, triggering an unprecedented international response. In the months that followed, international news, legal, development, human rights, and solidarity agencies highlighted the issue of gender-based violence, which has by all accounts increased since the earthquake. Despite activists' nuanced understanding and efforts, official responses have been inadequate while reproducing troubling, albeit familiar, discourses that tend to trigger either denial or demonization. This article aims to address this situation by offering necessary context, grounding violence in Haitian women's own analyses, before and after the earthquake. To understand the narratives and realities Haitian women face, it is critical to first understand structural violence, the long-term, often invisible system of inequality and poverty and how structural violence intersects with intersectionality, the multiple forms of oppression based on distinct but overlapping identities, such as of race, class, gender, sexuality, age, and parental status. As in other contexts, these pre-existing gender inequalities rendered Haitian women more vulnerable to disasters. Through the testimonies and lived realities of Haitian women, this article highlights the continuities and argues for the need for intersectional interventions grounded in Haitian women's own lived experiences and priorities.
Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil

The adequate amount of drug delivery to the brain in neurological patients is a major problem faced by the physicians. Recent studies suggested that intranasal administration of liposomal formulation may improve the drug delivery to the brain. In the present study, an attempt was made to study the brain bioavailability of commonly used anti-Alzheimer drug donepezil (DNP) liposomal formulation by intranasal route in rats. We adopted the thin layer hydration technique for the preparation of liposomes by using cholesterol, polyethylene glycol, and 1,2-distearyl-sn-glycero-3-phosphocholine (DSPC). The prepared liposomes were characterized by determining particle size, shape, surface morphology, zeta potential, encapsulation efficiency, and in vitro release of DNP. The pharmacokinetic parameters of liposomal DNP in plasma and brain of rats were determined following oral and nasal administration. The results of this study showed that the DNP liposomal formulation was stable with a consistent size (102 ± 3.3 nm) and shape. The prepared liposomes showed high encapsulation efficiency (84.91% ±3 .31%) and sustained-release behavior. The bioavailability of DNP in plasma and brain increased significantly (P<0.05) after administration of liposomal formulation by the intranasal route. Histopathological examination showed that the formulation was safe and free from toxicity. It can be concluded that the nasal administration of liposomal preparation may provide an efficient and reliable mode of drug delivery to the central nervous system.