Miracle-dz/UniFAR-FTUs huggingface dataset:
Pregnancy Complications as Markers for Subsequent Maternal Cardiovascular Disease: Validation of a Maternal Recall Questionnaire.

BACKGROUND We designed and tested the validity of a questionnaire to characterize maternal recall of pregnancy complications associated with increased future cardiovascular disease risk, based on the 2011 American Heart Association (AHA) guidelines. METHODS A maternal recall questionnaire of pregnancy history was administered to 971 patients who had participated in a previous cohort study of 1,608 pregnant women. Medical records from the study pregnancy served as the gold standard. Prevalence, sensitivity (sens), specificity (spec), positive predictive value (PPV), negative predictive value (NPV), and/or Spearman's correlation coefficients (r) were calculated for each question. RESULTS A total of 526 (54%) individuals recontacted responded. Respondents were more likely to be older, white, educated, and nulliparous and were less likely to deliver low-birthweight infants in the study pregnancy than were individuals who did not respond. Mean length of recall was 4.35 years (standard deviation [SD] 0.46) postpartum. Maternal recall was most accurate for gestational diabetes (sens: 92%, spec: 98%, PPV: 79%, NPV: 99%), infant birthweight (r=0.95), and gestation length (r=0.85). Maternal recall was modest for preeclampsia (sens: 79%, spec: 97%, PPV: 68%, NPV: 98%) and pregnancy-associated hypertension, including preeclampsia or gestational hypertension (sens: 60%, spec: 95%, PPV: 64%, NPV: 94%). CONCLUSIONS This validation study demonstrated that the majority of women could accurately recall a history of gestational diabetes, infant birthweight, and gestational age at delivery, 4 years postpartum on average. Recall of preeclampsia and pregnancy-associated hypertension overall was modest. Maternal report of these pregnancy conditions may help clinicians identify women at increased risk for cardiovascular disease.
TSCA: A Temporal-Spatial Real-Time Charging Scheduling Algorithm for On-Demand Architecture in Wireless Rechargeable Sensor Networks

The collaborative charging issue in Wireless Rechargeable Sensor Networks (WRSNs) is a popular research problem. With the help of wireless power transfer technology, electrical energy can be transferred from wireless charging vehicles (WCVs) to sensors, providing a new paradigm to prolong network lifetime. Existing techniques on collaborative charging usually take the periodical and deterministic approach, but neglect influences of non-deterministic factors such as topological changes and node failures, making them unsuitable for large-scale WRSNs. In this paper, we develop a temporal-spatial charging scheduling algorithm, namely TSCA, for the on-demand charging architecture. We aim to minimize the number of dead nodes while maximizing energy efficiency to prolong network lifetime. First, after gathering charging requests, a WCV will compute a feasible movement solution. A basic path planning algorithm is then introduced to adjust the charging order for better efficiency. Furthermore, optimizations are made in a global level. Then, a node deletion algorithm is developed to remove low efficient charging nodes. Lastly, a node insertion algorithm is executed to avoid the death of abandoned nodes. Extensive simulations show that, compared with state-of-the-art charging scheduling algorithms, our scheme can achieve promising performance in charging throughput, charging efficiency, and other performance metrics.
A Diagnostic Pointer to Adult Metachromatic Leucodystrophy

Adult metachromatic leucodystrophy (MLD) is a rare demyelinating disease of the central nervous system caused by a genetic autosomal recessive defect and mediated through a deficiency in the enzyme arylsulphatase A (Peiffer, 1970). The initial manifestation may take the form of symptoms suggestive of schizophrenia or dementia (Sourander et al, 1962; Austin et al, 1968).
Drizzle in Stratiform Boundary Layer Clouds

This is the second of two observational papers examining drizzle in stratiform boundary layer clouds. Part I details the vertical and horizontal structure of cloud and drizzle parameters, including some bulk microphysical variables. In this paper, the focus is on the in situ size-resolved microphysical measurements, particularly of drizzle drops (r 20 m). Layer-averaged size distributions of drizzle drops within cloud are shown to be well represented using either a truncated exponential or a truncated lognormal size distribution. The size-resolved microphysical measurements are used to estimate autoconversion and accretion rates by integration of the stochastic collection equation (SCE). These rates are compared with a number of commonly used bulk parameterizations of warm rain formation. While parameterized accretion rates agree well with those derived from the SCE initialized with observed spectra, the autoconversion rates seriously disagree in some cases. These disagreements need to be addressed in order to bolster confidence in large-scale numerical model predictions of the aerosol second indirect effect. Cloud droplet coalescence removal rates and mass and number fall rate relationships used in the bulk microphysical schemes are also compared, revealing some potentially important discrepancies. The relative roles of autoconversion and accretion are estimated by examination of composite profiles from the 12 flights. Autoconversion, although necessary for the production of drizzle drops, is much less important than accretion throughout the lower 80% of the cloud layer in terms of the production of drizzle liquid water. The SCE calculations indicate that the autoconversion rate depends strongly upon the cloud droplet concentration Nd such that a doubling of Nd would lead to a reduction in autoconversion rate of between 2 and 4. Radar reflectivity–precipitation rate (Z–R) relationships suitable for radar use are derived and are shown to be significantly biased in some cases by the undersampling of large (r 200 m) drops with the 2D-C probe. A correction based upon the extrapolation to larger sizes using the exponential size distribution changes the Z–R relationship, leading to the conclusion that consideration should be given to sampling issues when examining higher moments of the drop size distribution in drizzling stratiform boundary layer clouds.
Gemcitabine versus gemcitabine/carboplatin in advanced non-small cell lung cancer: preliminary findings in a phase III trial of the Swedish Lung Cancer Study Group.

Gemcitabine is an active agent in non-small cell lung cancer, with single-agent treatment producing response rates of approximately 20% and median survivals of approximately 7 to 9 months. In a pilot trial in advanced non-small cell lung cancer, the gemcitabine/carboplatin combination produced a response rate of 43% and median survival of 12 months with good tolerability. Preliminary results of a phase III trial comparing gemcitabine alone with gemcitabine/carboplatin in 332 patients with stage IIIB or IV non-small cell lung cancer are now available. Patients were randomized to receive gemcitabine 1,250 mg/m(2) on days 1 and 8 every 21 days or the same gemcitabine regimen plus carboplatin at an area under the concentration-time curve of 5 mg/mL/min on day 1 for a maximum of six cycles. Hematologic toxicity was more common in the combination arm; grade 4 thrombocytopenia occurred in 23.5% v 5.3% of patients, but infrequently resulted in clinical complications. Nonhematologic toxicity was moderate and similar in frequency in the combination and gemcitabine arms (25% and 28%, respectively). Among 275 patients, overall response rates were 30% (2% complete response and 28% partial response) in the combination arm and 12% (all partial responses) in the gemcitabine arm. Median time to disease progression was 6 months in the combination arm and 4 months in the gemcitabine arm. Median survival in the study population was 9 months, a promising finding given the high proportion of elderly patients in the study (37% >/= 70 years of age). Full mature results of the trial, including comparative survival results and data on quality of life, are awaited.
Differential Regulation of the Nature and Functions of Dendritic Cells and Macrophages by Cathepsin E

The aspartic proteinase cathepsin E is localized mainly in the endosomal structures of APCs and has been implicated in a variety of immune responses, however, the precise roles of cathepsin E in these cells remain speculative. In this study, we report the effect of disrupting the gene encoding cathepsin E on the nature and functions of dendritic cells (DCs) and macrophages derived from mouse bone marrow precursors, as well as mouse peritoneal macrophages. Whereas cathepsin E deficiency induced the accumulation of the lysosome-associated membrane protein (LAMP)-1 and LAMP-2 and elevated the lysosomal pH in macrophages, it did not have these effects on DCs. Although cathepsin E deficiency also caused a marked decrease in degradation of phagocytosed OVA and chemotactic responses to MCP-1 and fMLP by macrophages, these abilities were little affected in DCs by the absence of cathepsin E. Interestingly, cathepsin E deficiency markedly decreased the ability of macrophages to present intact OVA, as well as an OVA-derived antigenic peptide (266–281), to cognate T cells, while that of DCs was inversely enhanced by the absence of this protein. This paradox was resolved, in part, by the enhanced phagocytic activity and the increased expression of the costimulatory molecules CD86, CD80, and CD40, which amplify the response of T cells, in cathepsin E-deficient DCs compared with the wild-type cells. These results indicate that cathepsin E differentially regulates the nature and function of DCs and macrophages.
THE COMPUTER USE INTENTION (CUI) SCALE IN EDUCATION: DEVELOPMENT, VALIDITY AND RELIABILITY STUDIES

The main aim of this research was to develop an instrument to examine the intention of computer use among student teachers and provide an initial psychometric evaluation of the Computer Use Intention (CUI) scale among student teachers. The process of item generation for the CUI scale was carried out through the sequential mixed method approach. A total of 177 student teachers from a teacher education participated in this study. Based on the exploratory factor analysis (EFA) results, it yielded a four-factorial with 12 items in the CUI scale. The researchers then carried out a confirmatory factor analysis (CFA) to assess its factorial validity and reliability. Based on the findings, the CUI scale reached the minimum thresholds for acceptable scale. Convergent validity and discriminant validity of the CUI scale shows satisfactory validity and good internal consistency for all 12-item of CUI scale.
Reliability and security analysis of open source software

Existing reliability prediction and security assessment of open source software systems seem to focus on analysis based primarily on the number of faults reported against the software. Since information like problem reports, soft ware usage level, and project’s behavior in terms of time taken to fix a problem report are publicly available, it is advantageous to also consider these factors in analyzing open source projects. We study the characteristics of FEDORA (a popular open source project) problem reports for different releases and show that traditional reliability models c an be utilized for prediction of problem rates across releases . Also, we estimate the risk exposure due to security problem reports, a subset of the total problem reports. We discuss metrics that could help end-users assess the trustworthine ss of open source projects.
Disability Harassment Observed by Teachers in Special Education

The occurrence and impact of disability harassment of students in special education apparently have a low priority for official policy makers and education administrators. Literature on policies of generic school bullying, one state's prohibition of pupil harassment, and a federal memorandum of school-based disability harassment are reviewed. The purpose of this preliminary study is to investigate observed occurrences of harassment of students with disabilities based on 15 specific types of harassment conduct and explore potential policy implications of such conduct. Ninety special education teachers from a large public school district reported on their direct observations of harassment of their students. The most frequently reported types that occur “many times” in rank order include epithets, slurs, mimicking, mockery, and staring. Overall, 96.7% of the participants report that they observed more than one incident of these types of school-related disability harassment conduct. Implications, study limitations, and recommendations for research and policy are discussed.
An Electronic Publication Dedicated to Early Stellar Evolution and Molecular Clouds a Hybrid Scenario for the Formation of Brown Dwarfs and Very Low Mass Stars

s of recently accepted papers Deserts and pileups in the distribution of exoplanets due to photoevaporative disc clearing We present models of giant planet migration in evolving protoplanetary discs. We show that disc clearing by EUV photoevaporation can have a strong effect on the distribution of giant planet semi-major axes. During disc clearing planet migration is slowed or accelerated in the region where photoevaporation opens a gap in the disc, resulting in " deserts " where few giant planets are found and corresponding " pileups " at smaller and larger radii. However, the precise locations and sizes of these features are strong functions of the efficiency of planetary accretion, and therefore also strongly dependent on planet mass. We suggest that photoevaporative disc clearing may be responsible for the pileup of ∼Jupiter-mass planets at ∼ 1AU seen in exoplanet surveys, and show that observations of the distribution of exoplanet semi-major axes can be used to test models of both planet migration and disc clearing. We present a calculation of protostellar disk formation and evolution in which gaseous clumps (essentially, the first Larson cores formed via disk fragmentation) are ejected from the disk during the early stage of evolution. This is a universal process related to the phenomenon of ejection in multiple systems of point masses. However, it occurs in our model entirely due to the interaction of compact, gravitationally-bound gaseous clumps and is free from the smoothing-length uncertainty that is characteristic of models using sink particles. Clumps that survive ejection span a mass range of 0.08–0.35 M ⊙ , and have ejection velocities 0.8 ± 0.35 km s −1 , which are several times greater than the escape speed. We suggest that, upon contraction, these clumps can form substellar or low-mass stellar objects with notable disks, or even close-separation very-low-mass binaries. In this hybrid scenario, allowing for ejection of clumps rather than finished protostars/proto–brown-dwarfs, disk formation and the low velocity dispersion of low-mass objects are naturally explained, while it is also consistent with the observation of isolated low-mass clumps that are ejection products. We conclude that clump ejection and the formation of isolated low mass stellar and substellar objects is a common occurrence, with important implications for understanding the initial mass function, the brown dwarf desert, and the formation of stars in all environments and epochs.
Mitochondrial biogenesis in cold-bodied fishes

Summary Mitochondrial biogenesis is induced in response to cold temperature in many organisms. The effect is particularly pronounced in ectotherms such as fishes, where acclimation to cold temperature increases mitochondrial density. Some polar fishes also have exceptionally high densities of mitochondria. The net effect of increasing mitochondrial density is threefold. First, it increases the concentration of aerobic metabolic enzymes per gram of tissue, maintaining ATP production. Second, it elevates the density of mitochondrial membrane phospholipids, enhancing rates of intracellular oxygen diffusion. Third, it reduces the diffusion distance for oxygen and metabolites between capillaries and mitochondria. Although cold-induced mitochondrial biogenesis has been well documented in fishes, little is known about the molecular pathway governing it. In mammals, the co-transcriptional activator peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is thought to coordinate the three components of mitochondrial biogenesis: the synthesis of mitochondrial proteins, the synthesis of phospholipids and the replication of mitochondrial DNA. Some components of the mitochondrial biogenic pathway are conserved between fishes and mammals, yet the pathway appears more versatile in fishes. In some tissues of cold-acclimated fishes, the synthesis of mitochondrial proteins increases in the absence of an increase in phospholipids, whereas in some polar fishes, densities of mitochondrial phospholipids increase in the absence of an increase in proteins. The ability of cold-bodied fishes to fine-tune the mitochondrial biogenic pathway may allow them to modify mitochondrial characteristics to meet the specific needs of the cell, whether it is to increase ATP production or enhance oxygen diffusion.
Why does inflation start at the top of the hill

We show why the universe started in an unstable de Sitter state. The quantum origin of our universe implies one must take a ``top down'' approach to the problem of initial conditions in cosmology, in which the histories that contribute to the path integral depend on the observable being measured. Using the no boundary proposal to specify the class of histories, we study the quantum cosmological origin of an inflationary universe in theories such as trace anomaly driven inflation in which the effective potential has a local maximum. We find that an expanding universe is most likely to emerge in an unstable de Sitter state, by semiclassical tunneling via a Hawking-Moss instanton. Since the top down view is forced upon us by the quantum nature of the universe, we argue that the approach developed here should still apply when the framework of quantum cosmology will be based on M theory.
CONFLICTS AS PROPERTY

CONFLICTS are seen as important elements in society. Highly industrialised societies do not have too much internal conflict, they have too little. We have to organise social systems so that conflicts are both nurtured and made visible and also see to it that professionals do not monopolise the handling of them. Victims of crime have in particular lost their rights to participate. A court procedure that restores the participants' rights to their own conflicts is outlined.
Crystallization of Calcium Carbonate in Alginate and Xanthan Hydrogels

Calcium carbonate polymorphs were crystallized in alginate and xanthan hydrogels in which a degree of entanglement was altered by the polysaccharide concentration. Both hydrogels contain functional groups (COOH and OH) attached at diverse proportions on saccharide units. In all systems, the precipitation process was initiated simultaneously with gelation, by the fast mixing of the calcium and carbonate solutions, which contain the polysaccharide molecules at respective concentrations. The initial supersaturation was adjusted to be relatively high in order to ensure the conditions suitable for nucleation of all CaCO3 polymorphs and amorphous phase(s). In the model systems (no polysaccharide), a mixture of calcite, vaterite and amorphous calcium carbonate initially precipitated, but after short time only calcite remained. In the presence of xanthan hydrogels, precipitation of either, calcite single crystals, porous polyhedral aggregates, or calcite/vaterite mixtures were observed after five days of ageing, because of different degrees of gel entanglement. At the highest xanthan concentrations applied, the vaterite content was significantly higher. In the alginate hydrogels, calcite microcrystalline aggregates, rosette-like and/or stuck-like monocrystals and vaterite/calcite mixtures precipitated as well. Time resolved crystallization experiments performed in alginate hydrogels indicated the initial formation of a mixture of calcite, vaterite and amorphous calcium carbonate, which transformed to calcite after 24 h of ageing.
Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields

At high magnetic fields (7 and 8.4 T), water proton magnetic resonance images of brains of live mice and rats under pentobarbital anesthetization have been measured by a gradient echo pulse sequence with a spatial resolution of 65 × 65‐μm pixel size and 700‐μm slice thickness. The contrast in these images depicts anatomical details of the brain by numerous dark lines of various sizes. These lines are absent in the image taken by the usual spin echo sequence. They represent the blood vessels in the image slice and appear when the deoxyhemoglobin content in the red cells increases. This contrast is most pronounced in an anoxy brain but not present in a brain with diamagnetic oxy or carbon monoxide hemoglobin. The local field induced by the magnetic susceptibility change in the blood due to the paramagnetic deoxyhemoglobin causes the intra voxel dephasing of the water signals of the blood and the surrounding tissue. This oxygena‐tion‐dependent contrast is appreciable in high field images with high spatial resolution. © 1990 Academic Press, Inc.
A role for the Tubby-like protein 1 in rhodopsin transport.

PURPOSE To test the hypothesis that a lack of Tubby-like protein 1 (TULP1) function causes aberrant transport of nascent rhodopsin and to examine the functional relationship between the homologous proteins TULP1 and Tubby by studying mice carrying combined mutations. METHODS Subcellular localization of TULP1 and rhodopsin in photoreceptors was determined by immunofluorescence and by postembedding immunoelectron microscopy. Mice carrying different tulp1/tubby allele combinations were examined by histology, electroretinograms (ERGs), and immunofluorescence microscopy. RESULTS TULP1 is distributed throughout the photoreceptor cytoplasm but is excluded from the outer segments and the nuclei. In the tulp1-/- mice, ectopic accumulation of rhodopsin occurs at an early age. Both the vesicular profiles in the interphotoreceptor space and the inner segment plasma membranes are immunoreactive for rhodopsin. Mice doubly homozygous for null mutations in the tulp1 and tubby genes initially develop photoreceptors and express a battery of photoreceptor markers at age 14 days. Thereafter their photoreceptors undergo a fulminant degeneration that reaches completion by postnatal day 17. The disease phenotype in the double homozygote is much more severe than either single homozygote. Double heterozygotes are phenotypically normal. CONCLUSIONS A lack of TULP1 function results in misrouting of nascent rhodopsin. TULP1 may be a component of the cellular machinery that targets nascent rhodopsin to the outer segments. Comparison of disease phenotypes in the single and double mutants suggests that TULP1 and Tubby are not functionally interchangeable in photoreceptors nor do they form an obligate functional complex.
EMDR treatment of Panic Disorder with and without Agoraphobia: Two Model Treatment Plans

This presentation will review strengths and limitations of treatments for PD and PDA with a focus on cognitive and behavioral therapies, pharmacotherapy, and EMDR, and will present two EMDR treatment plans: a Model I plan for PD without agoraphobia or other co-occurring disorders; and a Model II plan for more complex cases of PDA or PD with co-occurring anxiety or Axis II disorders. Clinical examples and specific guidelines will be presented for identifying PD targets and for when to extend preparation phase work and postpone reprocessing of core attachment material in Model II cases.