Miracle-dz/UniFAR-FTUs huggingface dataset:
The cognitive functioning of older adult instrumental musicians and non-musicians

ABSTRACT This study examined similarities and differences in the cognitive profiles of older adult instrumental musicians and non-musicians. We compared neuropsychological test scores among older adult non-musicians, low-activity musicians (<10 years of lessons), and high-activity musicians (≥10 years of lessons), controlling for self-reported physical and social activity, years of education, and overall health. Significant differences among groups were found on tasks of visual spatial ability, naming, and executive functioning. No significant differences were found on tests of attention/processing speed, or episodic memory. The current study supports late life cognitive benefits of early musical training, but only in select cognitive domains, including language, executive functioning, and visual spatial ability. The results are discussed in the context of cognitive reserve and aging.
CHEMICAL SYNTHESIS AND VISIBLE PHOTOLUMINESCENCE EMISSION FROM MONODISPERSED ZNO NANOPARTICLES

Monodispersed PVP capped nanoparticles of ZnO have been prepared in double distilled water through chemical technique. Nanostructures of the prepared ZnO particles have been confirmed through XRD, TEM, and UV-VIS absorption characterizations. The average size of the prepared ZnO nanoparticles is as small as 1.9 nm. A strong green photoluminescence emission under UV excitation is reported from the prepared ZnO nanoparticles due to the recombination of a photo-generated hole with a singly ionized charge state. (Received December 6, 2008; accepted December 15, 2008)
An attention‐based BiLSTM‐CRF approach to document‐level chemical named entity recognition

Motivation In biomedical research, chemical is an important class of entities, and chemical named entity recognition (NER) is an important task in the field of biomedical information extraction. However, most popular chemical NER methods are based on traditional machine learning and their performances are heavily dependent on the feature engineering. Moreover, these methods are sentence‐level ones which have the tagging inconsistency problem. Results In this paper, we propose a neural network approach, i.e. attention‐based bidirectional Long Short‐Term Memory with a conditional random field layer (Att‐BiLSTM‐CRF), to document‐level chemical NER. The approach leverages document‐level global information obtained by attention mechanism to enforce tagging consistency across multiple instances of the same token in a document. It achieves better performances with little feature engineering than other state‐of‐the‐art methods on the BioCreative IV chemical compound and drug name recognition (CHEMDNER) corpus and the BioCreative V chemical‐disease relation (CDR) task corpus (the F‐scores of 91.14 and 92.57%, respectively). Availability and implementation Data and code are available at https://github.com/lingluodlut/Att‐ChemdNER. Supplementary information Supplementary data are available at Bioinformatics online.
Adaptive Signal Detection and Parameter Estimation in Unknown Colored Gaussian Noise

This paper considers the general signal detection and parameter estimation problem in the presence of colored Gaussian noise disturbance. By modeling the disturbance with an autoregressive process, we present three signal detectors with different unknown parameters under the general framework of binary hypothesis testing. The closed form of parameter estimates and the asymptotic distributions of these three tests are also given. Given two examples of frequency modulated signal detection problem and time series moving object detection problem, the simulation results demonstrate the effectiveness of three presented detectors.
Potassium ions intercalated into g-C3N4-modified TiO2 nanobelts for the enhancement of photocatalytic hydrogen evolution activity under visible-light irradiation

Solar-to-chemical energy conversion is a challenging photochemical reaction for renewable energy storage. In recent decades, photocatalytic H2 evolution has been studied extensively. TiO2 is a well-established semiconductor in the field of photocatalytic H2 production; however, its low efficiency for solar energy utilization, and high photocarrier recombination rate, restrict its photocatalytic efficiency. Here, a series of K-intercalated g-C3N4-modified TiO2 nanobelts (TCN–Kx) with different dosages of K atoms were fabricated using a hydrothermal method followed by a calcination process. XRD, TEM and XPS tests indicate that a tight interfacial connection is formed between K–g-C3N4 and the TiO2 nanobelts. DFT calculations indicated that K dopants prefer to be at the interlayer sites of g-C3N4, suggesting increased charge transfer efficiency. The H2 production efficiency of the TCN–Kx composite materials from water splitting under visible-light irradiation was clearly improved. Steady fluorescence spectroscopy and photocurrent measurements confirmed that the improvement in photocatalytic H2 production activity was due to the superior charge separation and electron transfer efficiency of TCN–Kx composite materials.
Halothane Increases Smooth Muscle Protein Phosphatase in Airway Smooth Muscle

BackgroundHalothane relaxes airway smooth muscle, in part, by decreasing the force produced for a given intracellular [Ca2+] (i.e., Ca2+ sensitivity) during muscarinic stimulation, an effect produced by a decrease in regulatory myosin light-chain (rMLC) phosphorylation. The authors tested the hypothesis that halothane reduces rMLC phosphorylation during muscarinic stimulation at constant intracellular [Ca2+] by increasing smooth muscle protein phosphatase (SMPP) activity, without changing myosin light-chain kinase (MLCK) activity. MethodsEnzyme activities were assayed in &bgr;-escin permeabilized strips of canine tracheal smooth muscle. Under conditions of constant intracellular [Ca2+], the rate of rMLC phosphorylation was measured by Western blotting during inhibition of SMPP with microcystin-LR (to assay MLCK activity) or during inhibition of MLCK by wortmannin and adenosine triphosphate depletion (to assay SMPP activity). The effect of halothane (0.8 mm) on enzyme activities and isometric force during stimulation with 0.6 &mgr;m Ca2+ and 10 &mgr;m acetylcholine was determined. ResultsHalothane produced a 14 ± 8% (mean ± SD) decrease in isometric force by significantly reducing rMLC phosphorylation (from 32 ± 9% to 28 ± 9%). Halothane had no significant effect on any parameter of a monoexponential relation fit to the data for the MLCK activity assay. In contrast, halothane significantly decreased the half-time for rMLC dephosphorylation in the SMPP activity assay (from 0.74 ± 0.28 min to 0.44 ± 0.10 min), indicating that it increased SMPP activity. ConclusionsHalothane decreases Ca2+ sensitivity and rMLC phosphorylation in airway smooth muscle during muscarinic receptor stimulation by increasing SMPP activity, without affecting MLCK, probably by disrupting receptor G-protein signaling pathways that inhibit SMPP.
Forced Aerobic Exercise Preceding Task Practice Improves Motor Recovery Poststroke

OBJECTIVE. To understand how two types of aerobic exercise affect upper-extremity motor recovery post-stroke. Our aims were to (1) evaluate the feasibility of having people who had a stroke complete an aerobic exercise intervention and (2) determine whether forced or voluntary exercise differentially facilitates upper-extremity recovery when paired with task practice. METHOD. Seventeen participants with chronic stroke completed twenty-four 90-min sessions over 8 wk. Aerobic exercise was immediately followed by task practice. Participants were randomized to forced or voluntary aerobic exercise groups or to task practice only. RESULTS. Improvement on the Fugl-Meyer Assessment exceeded the minimal clinically important difference: 12.3, 4.8, and 4.4 for the forced exercise, voluntary exercise, and repetitive task practice–only groups, respectively. Only the forced exercise group exhibited a statistically significant improvement. CONCLUSION. People with chronic stroke can safely complete intensive aerobic exercise. Forced aerobic exercise may be optimal in facilitating motor recovery associated with task practice.
Associations Between Objectively Measured Physical Activity and Executive Functioning in Young Adults

Associations between daily physical activity (PA) and executive functioning have rarely been investigated among young adults. This study examined these associations among 162 university students (74 females and 88 males; mean age = 19.0, SD = 1.1 years). We measured PA objectively, using hip-mounted accelerometers, and assessed executive functioning in a task-switching paradigm. Anthropometrics measurements were gathered using standardized procedures. Through linear regression modeling, we found moderate-to-vigorous physical activity (β = −0.19, 95% CI = [−0.35, −0.03], p = .02) and light physical activity (β = −0.17, 95% CI = [−0.34, −0.01], p = .04) to be associated with smaller global reaction time switch costs. Total PA was not associated with task-switching performance, and there were no statistically significant associations between PA indicators and local switch costs. As both moderate-to-vigorous and light physical activities were associated with better executive function in young adults, there can be important cognitive benefits to remaining physically active.
Serum Antibody Levels to the Pneumocystis jirovecii Major Surface Glycoprotein in the Diagnosis of P. jirovecii Pneumonia in HIV+ Patients

Background Pneumocystis jirovecii remains an important cause of fatal pneumonia (Pneumocystis pneumonia or PcP) in HIV+ patients and other immunocompromised hosts. Despite many previous attempts, a clinically useful serologic test for P. jirovecii infection has never been developed. Methods/Principal Findings We analyzed serum antibody responses to the P. jirovecii major surface glycoprotein recombinant fragment C1 (MsgC1) in 110 HIV+ patients with active PcP (cases) and 63 HIV+ patients with pneumonia due to other causes (controls) by an enzyme-linked immunosorbent assay (ELISA). The cases had significantly higher IgG and IgM antibody levels to MsgC1 than the controls at hospital admission (week 0) and intervals up to at least 1 month thereafter. The sensitivity, specificity and positive predictive value (PPV) of IgG antibody levels increased from 57.2%, 61.7% and 71.5% at week 0 to 63.4%, 100%, and 100%, respectively, at weeks 3–4. The sensitivity, specificity and PPV of IgM antibody levels rose from 59.7%, 61.3%, and 79.3% at week 0 to 74.6%, 73.7%, and 89.8%, respectively, at weeks 3–4. Multivariate analysis revealed that a diagnosis of PcP was the only independent predictor of high IgG and IgM antibody levels to MsgC1. A high LDH level, a nonspecific marker of lung damage, was an independent predictor of low IgG antibody levels to MsgC1. Conclusions/Significance The results suggest that the ELISA shows promise as an aid to the diagnosis of PCP in situations where diagnostic procedures cannot be performed. Further studies in other patient populations are needed to better define the usefulness of this serologic test.
Outcomes with single-coil versus dual-coil implantable cardioverter defibrillators: a meta-analysis

Aims Dual-coil implantable cardioverter defibrillator (ICD) leads have traditionally been used over single-coil leads due to concerns regarding high defibrillation thresholds (DFT) and consequent poor shock efficacy. However, accumulating evidence suggests that this position may be unfounded and that dual-coil leads may also be associated with higher complication rates during lead extraction. This meta-analysis collates data comparing dual- and single-coil ICD leads. Methods and results Electronic databases were systematically searched for randomized controlled trials (RCT) and non-randomized studies comparing single-coil and dual-coil leads. The mean differences in DFT and summary estimates of the odds-ratio (OR) for first-shock efficacy and the hazard-ratio (HR) for all-cause mortality were calculated using random effects models. Eighteen studies including a total of 138,124 patients were identified. Dual-coil leads were associated with a lower DFT compared to single coil leads (mean difference -0.83J; 95% confidence interval [CI] -1.39--0.27; P = 0.004). There was no difference in the first-shock success rate with dual-coil compared to single-coil leads (OR 0.74; 95%CI 0.45-1.21; P=0.22). There was a significantly lower risk of all-cause mortality associated with single-coil leads (HR 0.91; 95%CI 0.86-0.95; P < 0.0001). Conclusion This meta-analysis suggests that single-coil leads have a marginally higher DFT but that this may be clinically insignificant as there appears to be no difference in first-shock efficacy when compared to dual-coil leads. The mortality benefit with single-coil leads most likely represents patient selection bias. Given the increased risk and complexity of extracting dual-coil leads, centres should strongly consider single-coil ICD leads as the lead of choice for routine new left-sided ICD implants.
Results from the Balance Rehabilitation Unit in Benign Paroxysmal Positional Vertigo

Abstract Posturography is a useful new tool to study the influence of vestibular diseases on balance. Aim to compare the results from the Balance Rehabilitation Unit (BRU) static posturography in elderly patients with Benign Paroxysmal Positional Vertigo (BPPV), before and after Epley's maneuver. Materials and Methods a prospective study of 20 elderly patients with a diagnosis of BPPV. The patients underwent static posturography and the limit of stability (LE) and ellipse area were measured. We also applied the Dizziness Handicap Inventory (DHI) questionnaire to study treatment effectiveness. Results 80% were females, with a mean age of 68.15 years. After the maneuver, the LE increased significantly (p=0.001). The elliptical area of somatosensory, visual and vestibular conflicts (2,7,8,9 situations) in BRU and the DHI scores decreased significantly (p<0.05) after treatment. Conclusion the study suggests that elderly patients with BPPV may present static postural control impairment and that the maneuver is effective for the remission of symptoms, to increase in the stability and improvement in postural control in situations of visual, somatosensory and vestibular conflicts.
Psychometric validation of Fuld Object Memory Evaluation in older adults with cognitive impairments

ABSTRACT Objectives: Mild cognitive impairment (MCI) refers to an early but abnormal state of cognitive impairment with minimal functional impairment. The present study aimed to evaluate the validity of Fuld Object Memory Evaluation (FOME) as a measure of episodic memory function. Method: The study sample included 204 Chinese older adults with cognitive impairments. The participants completed five recall trials and a delayed trial in FOME, neurocognitive measures on digit spans and trail making, and daily functioning. Discriminative power of FOME to differentiate between MCI and dementia was inspected via receiver operating characteristic curve analysis. Results: FOME showed good test-retest reliability and convergent validity with digit spans and trail making. Controlling for gender, age, and education, lower levels of FOME total retrieval, verbal fluency, and daily functioning significantly predicted a higher likelihood of dementia compared to MCI. The optimal cut-off scores for total retrieval, verbal fluency, and daily functioning to differentiate dementia were 37/38 (77% sensitivity and 83% specificity), 28/29 (85% sensitivity and 72% specificity), and 14/15 (92% sensitivity and 78% specificity), respectively, in the younger subgroup. The corresponding figures were 34/35 (69% sensitivity and 76% specificity) and 27/28 (92% sensitivity and 62% specificity), and 11/12 (74% sensitivity and 80% specificity), respectively, in the older subgroup. Conclusion: The findings support the FOME as a valid assessment tool of episodic memory function in older Chinese adults. The combined use of FOME and daily functioning is recommended to distinguish persons with dementia from MCI.
Benefits of Imperfect Conflict Resolution Advisory Aids for Future Air Traffic Control

Objective: The aim of this study was to examine the human–automation interaction issues and the interacting factors in the context of conflict detection and resolution advisory (CRA) systems. Background: The issues of imperfect automation in air traffic control (ATC) have been well documented in previous studies, particularly in conflict-alerting systems. The extent to which the prior findings can be applied to an integrated conflict detection and resolution system in future ATC remains unknown. Method: Twenty-four participants were evenly divided into two groups corresponding to a medium– and a high–traffic density condition, respectively. In each traffic density condition, participants were instructed to perform simulated ATC tasks under four automation conditions, including reliable, unreliable with short time allowance to secondary conflict (TAS), unreliable with long TAS, and manual conditions. Dependent variables accounted for conflict resolution performance, workload, situation awareness, and trust in and dependence on the CRA aid, respectively. Results: Imposing the CRA automation did increase performance and reduce workload as compared with manual performance. The CRA aid did not decrease situation awareness. The benefits of the CRA aid were manifest even when it was imperfectly reliable and were apparent across traffic loads. In the unreliable blocks, trust in the CRA aid was degraded but dependence was not influenced, yet the performance was not adversely affected. Conclusion: The use of CRA aid would benefit ATC operations across traffic densities. Application: CRA aid offers benefits across traffic densities, regardless of its imperfection, as long as its reliability level is set above the threshold of assistance, suggesting its application for future ATC.
Triple phase computed tomography of the pancreas in healthy cats

While the availability and use of computed tomography (CT) continues to grow, no study has described the size and multiphase CT appearance of the normal feline pancreas. This information is important to not only allow more accurate identification and differentiation of disease, but it may also be useful in assessing pancreatic function. In this prospective analytical study, we described a triple phase CT protocol of the pancreas for use in sedated cats and the attenuation, enhancement pattern, size, and volume of the pancreas for a group of healthy cats. Fifteen healthy cats were enrolled in the study and a standardized protocol for acquiring arterial, portal, and delayed phase CT images of the pancreas was developed and described. The pancreas was hypo to isoattenuating to both the liver and spleen in all phases in the majority of cats with a homogenous enhancement pattern noted in all 15. Mean pancreatic attenuation was 48, 79, 166, and 126 Hounsfield units (HU) respectively on precontrast, arterial, portal, and delayed phase images. In addition, mean height, length, and width of the left lobe of the pancreas were larger than the right lobe in all 15 cats. There were no associations between volume and volume: body weight ratio with age (P = 0.6518, P = 0.6968) or sex (P = 0.7013, P = 0.2043). This baseline information may be beneficial for use in future studies characterizing pancreatic disease in cats as well as future research studies evaluating pancreatic endocrine function.
Population Pharmacokinetics and Exposure–Response Relationship of Carfilzomib in Patients With Multiple Myeloma

A population pharmacokinetic (PK) model and exposure–response (E‐R) analysis was developed using data collected from 5 phase 1b/2 and 2 phase 3 studies in subjects with multiple myeloma. Subjects receiving intravenous infusion on 2 consecutive days each week for 3 weeks (days 1, 2, 8, 9, 15, and 16) in each cycle at doses ranging from 15 to 20/56 mg/m2 (20 mg/m2 in cycle 1 and, if tolerated, escalated to 56 mg/m2 on day 8 of cycle 1). The population PK analysis indicated that among all the covariates tested, the only statistically significant covariate was body surface area on carfilzomib clearance; however, this covariate was unlikely to be clinically significant. Despite inclusion of different populations (relapsed or relapsed/refractory), treatments (carfilzomib monotherapy or combination therapy), infusion lengths (2 to 10 minutes or 30 minutes), and different doses, the E‐R analysis of efficacy showed that after adjusting for baseline characteristics, higher area under the concentration–time curve was associated with improved overall response rate (ORR), from 15 to 20/56 mg/m2. No positive relationships between maximum concentration and ORR were identified, indicating that ORR would not be expected to be impacted by infusion length. For safety end points, no statistically significant relationship between exposure and increasing risk of adverse events was identified. The results of an E‐R analysis provided strong support for a carfilzomib dose at 20/56 mg/m2 as a 30‐minute infusion for monotherapy and combination therapy. This article illustrates an example of application of E‐R analysis to support labeling dose recommendation in the absence of extensive clinical data.
Palette-Based Image Recoloring Using Color Decomposition Optimization

Previous works on palette-based color manipulation typically fail to produce visually pleasing results with vivid color and natural appearance. In this paper, we present an approach to edit colors of an image by adjusting a compact color palette. Different from existing methods that fail to preserve inherent color characteristics residing in the source image, we propose a color decomposition optimization for flexible recoloring while retaining these characteristics. For an input image, we first employ a variant of the $k$ -means algorithm to create a palette consisting of a small set of most representative colors. Next, we propose a color decomposition optimization to decompose colors of the entire image into linear combinations of basis colors in the palette. The captured linear relationships then allow us to recolor the image by recombining the coding coefficients with a user-modified palette. Qualitative comparisons with existing methods show that our approach can more effectively recolor images. Further user study quantitatively demonstrates that our method is a good candidate for color manipulation tasks. In addition, we showcase some applications enabled by our method, including pattern colorings suggesting, color transfer, tissue staining analysis and color image segmentation.