Miracle-dz/UniFAR-FTUs huggingface dataset:
A study of microstructure and wear behaviour of TiB2/Al metal matrix composites

The present paper deals with the study of microstructure and wear characteristics of TiB2 reinforced aluminium metal matrix composites (MMCs). Matrix alloys with 5, 10 and 15% of TiB2 were made using stir casting technique. Effect of sliding velocity on the wear behaviour and tribo-chemistry of the worn surfaces of both matrix and composites sliding against a EN24 steel disc has been investigated under dry conditions. A pin-on-disc wear testing machine was used to find the wear rate, in which EN24 steel disc was used as the counter face, loads of 10-60N in steps of 10N and speeds of 100, 200, 300, 400 and 500 rpm were employed. The results showed that the wear rate was increased with an increase in load and sliding speed for both the materials. However, a lower wear rate was obtained for MMCs when compared to the matrix alloys. The wear transition from slight to severe was presented at the critical applied loads. The transition loads for the MMCs were much higher than that of the matrix alloy. The transition loads were increased with increase in TiB2 and the same was decreased with the increase of sliding speeds. The SEM and EDS analyses were undertaken to demonstrate the effect of TiB2 particles on the wear mechanism for each conditions.
BORG: Block-reORGanization for Self-optimizing Storage Systems

This paper presents the design, implementation, and evaluation of BORG, a self-optimizing storage system that performs automatic block reorganization based on the observed I/O workload. BORG is motivated by three characteristics of I/O workloads: non-uniform access frequency distribution, temporal locality, and partial determinism in non-sequential accesses. To achieve its objective, BORG manages a small, dedicated partition on the disk drive, with the goal of servicing a majority of the I/O requests from within this partition with significantly reduced seek and rotational delays. BORG is transparent to the rest of the storage stack, including applications, file system(s), and I/O schedulers, thereby requiring no or minimal modification to storage stack implementations. We evaluated a Linux implementation of BORG using several real-world workloads, including individual user desktop environments, a web-server, a virtual machine monitor, and an SVN server. These experiments comprehensively demonstrate BORG's effectiveness in improving I/O performance and its incurred resource overhead.
A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention

The etiological treatment of Chagas disease is recommended for all patients with acute or recent chronic infection, but controversies remain regarding the benefit of chemotherapy and interpretations of the parasitological cure after etiological treatment. This study compares the laboratory and clinical evaluations of Chagas disease patients who were diagnosed 13 years earlier. Fifty-eight Chagas disease patients (29 treated with benznidazole and 29 untreated) were matched at the time of treatment based on several variables. Conventional serology revealed the absence of seroconversion in all patients. However, lower serological titres were verified in the treated group, primarily among patients who had the indeterminate form of the disease. Haemoculture performed 13 years after the intervention was positive for 6.9% and 27.6% of the treated and untreated patients, respectively. Polymerase chain reaction tests were positive for 44.8% and 13.8% of the treated and untreated patients, respectively. Patients who presented with the indeterminate form of the disease at the beginning of the study exhibited less clinical progression (17.4%) compared with the untreated group (56.5%). Therefore, this global analysis revealed that etiological treatment with benznidazole may benefit patients with respect to the clinical progression of Chagas disease and the prognosis, particularly when administered to patients with the indeterminate form of the disease.
In vivo application of Granulocyte-Macrophage Colony-stimulating Factor enhances postoperative qualitative monocytic function

BACKGROUND: Granulocyte macrophage colony-stimulating factor (GM-CSF) can be used as a potent stimulator for immune suppressed patients as defined by a decrease of human leukocyte antigen-D related expression on monocytes (mHLA-DR) after surgery. However, the exact role of GM-CSF on monocytic and T cell function is unclear. METHODS: In this retrospective randomized controlled trial (RCT) subgroup analysis, monocytic respectively T cell function and T cell subspecies of 20 immune suppressed (i.e. mHLA-DR levels below 10,000 monoclonal antibodies (mAb) per cell at the first day after surgery) patients after esophageal or pancreatic resection were analyzed. Each 10 patients received either GM-CSF (250 μg/m²/d) or placebo for a maximum of three consecutive days if mHLA-DR levels remained below 10,000 mAb per cell. mHLA-DR and further parameters of immune function were measured preoperatively (od) until day 5 after surgery (pod5). Statistical analyses were performed using nonparametric statistical procedures. RESULTS: In multivariate analysis, mHLA-DR significantly differed between the groups (p < 0.001). mHLA-DR was increased on pod2 (p < 0.001) and pod3 (p = 0.002) after GM-CSF application. Tumor necrosis factor-α (TNF-α) release of lipopolysaccharide (LPS) stimulated monocytes multivariately significantly differed between the groups (p < 0.008) and was increased in the GM-CSF group on pod2 (p < 0.001) and pod3 (p = 0.046). Th17/regulatory T (Treg) cell ratio was higher after GM-CSF treatment on pod2 (p = 0.041). No differences were seen in lymphocytes and T helper cell (Th)1/Th2 specific cytokine production after T cell stimulation with Concanavalin (Con) A between the groups. CONCLUSIONS: Postoperative application of GM-CSF significantly enhanced qualitative monocytic function by increased mHLA-DR and TNF-α release after LPS stimulation and apparently enhanced Th17/Treg ratio. Clinical trial registered with www.controlled-trials.com (ISRCTN27114642) 05 December 2008.
School Connectedness Is an Underemphasized Parameter in Adolescent Mental Health: Results of a Community Prediction Study

There is limited prospective research on the relation between school connectedness (i.e., the extent to which students feel accepted, valued, respected, and included in the school) and mental health symptoms in adolescents. A sample of 2,022 students (999 boys and 1,023 girls) ages 12 to 14 years were measured at 2 time points (12 months apart) on school connectedness and mental health symptoms (general functioning, depression, and anxiety symptoms). School connectedness correlated extensively with concurrent mental health symptoms at both time points (between 38% and 55% covariation with depression, 26% to 46% with general functioning, and 9% and 16% for anxiety symptoms). Using hierarchical linear modeling, school connectedness also predicted depressive symptoms 1 year later for both boys and girls, anxiety symptoms for girls, and general functioning for boys, even after controlling for prior symptoms. The reverse, however, was not true: Prior mental health symptoms did not predict school connectedness 1 year later when controlling for prior school connectedness. Results suggest a stronger than previously reported association with school connectedness and adolescent depressive symptoms in particular and a predictive link from school connectedness to future mental health problems.
Quantitative Mass Spectrometry Reveals Plasticity of Metabolic Networks in Mycobacterium smegmatis *

Mycobacterium tuberculosis has a remarkable ability to persist within the human host as a clinically inapparent or chronically active infection. Fatty acids are thought to be an important carbon source used by the bacteria during long term infection. Catabolism of fatty acids requires reprogramming of metabolic networks, and enzymes central to this reprogramming have been targeted for drug discovery. Mycobacterium smegmatis, a nonpathogenic relative of M. tuberculosis, is often used as a model system because of the similarity of basic cellular processes in these two species. Here, we take a quantitative proteomics-based approach to achieve a global view of how the M. smegmatis metabolic network adjusts to utilization of fatty acids as a carbon source. Two-dimensional liquid chromatography and mass spectrometry of isotopically labeled proteins identified a total of 3,067 proteins with high confidence. This number corresponds to 44% of the predicted M. smegmatis proteome and includes most of the predicted metabolic enzymes. Compared with glucose-grown cells, 162 proteins showed differential abundance in acetate- or propionate-grown cells. Among these, acetate-grown cells showed a higher abundance of proteins that could constitute a functional glycerate pathway. Gene inactivation experiments confirmed that both the glyoxylate shunt and the glycerate pathway are operational in M. smegmatis. In addition to proteins with annotated functions, we demonstrate carbon source-dependent differential abundance of proteins that have not been functionally characterized. These proteins might play as-yet-unidentified roles in mycobacterial carbon metabolism. This study reveals several novel features of carbon assimilation in M. smegmatis, which suggests significant functional plasticity of metabolic networks in this organism.
Independent components of magnetoencephalography: Localization and single-trial response onset detection

Independent component analysis (ICA) is a class of decomposition methods that separate sources from mixtures of signals. In this chapter, we used second order blind identification (SOBI), one of the ICA method, to demonstrate its advantages in identifying magnetic signals associated with neural information processing. Using 122-channel MEG data collected during both simple sensory activation and complex cognitive tasks, we explored SOBI’s ability to help isolate and localize underlying neuronal sources, particularly under relatively poor signal-to-noise conditions. For these identified and localized neuronal sources, we developed a simple threshold-crossing method, with which single-trial response onset times could be measured with a detection rate as high as 96%. These results demonstrated that, with the aid of ICA, it is possible to non-invasively measure human single trial response onset times with millisecond resolution for specific neuronal populations from multiple sensory modalities. This capability makes it possible to study a wide range of perceptual and memory functions that critically depend on the timing of discrete neuronal events.
Can We Ever Escape from Data Overload? A Cognitive Systems Diagnosis

Data overload is a generic and tremendously difficult problem. We examine three characterizations of the data overload problem and how they lead to different proposed solutions. The first characterization is a clutter problem where there is “too much stuff,” which leads to proposals to reduce the number of data units that are displayed. The second characterization is a workload bottleneck where there is too much data to process in the time available. Data overload as a workload bottleneck shifts the view to practitioner activities rather than elemental data and leads to proposals to use automation to perform activities for the practitioner. The third characterization is a problem in finding the significance of data when it not known a priori what data will be informative. This characterization leads to model-based abstractions and representation design techniques as potential solutions. Many of the existing approaches to coping with data overload avoid directly confronting the problem that what is significant depends on context. We advocate an alternative approach that depends on model-based organization of the data in a conceptual space that depicts the relationships, events, and contrasts that are informative in a field of practice and uses active machine intelligence in circumscribed, cooperative roles to aid human observers in organizing, selecting, managing, and interpreting data.
The life-cycle and host preferences of the bird cherry-oat aphid, Rhopalosiphum padi L., and their bearing on the theories of host alternation in aphids.

SUMMARY Emigrants of the host-alternating bird cherry-oat aphid fly from the primary host to various grasses before the end of June, even in the absence of natural enemies on bird cherry. They fly before the leaves of bird cherry mature and at a time when numbers of insect predators are rapidly increasing. In the autumn gynoparae and males return to bird cherry whose senescing leaves again provide the aphids with a rich source of food. The growth efficiency of R. padi on bird cherry and oats indicates that the quality of the available food on the two hosts is markedly different. Apterous exules prefer oats to young bird cherry leaves and survive best on oats. Gynoparae prefer bird cherry leaves and only successfully produce offspring on the primary host. This, and other work published on R. padi, support the premise that a change in the aphid's preferences causes the change of host. The dual-discrimination theory of host alternation in aphids is examined in the light of this and other published work.
Nivolumab-induced myasthenia gravis in a patient with squamous cell lung carcinoma

Rationale: Nivolumab (Nivo) is an immune checkpoint inhibitor that has been used to treat advanced melanoma, nonsmall cell lung carcinoma, and renal cell carcinoma since 2015. Nivo is associated with several side effects, including hepatitis, pneumonitis, acute renal failure, endocrine disorder, and other immune-related adverse events. Here, we describe the case of a 65-year-old man with squamous cell lung carcinoma who developed myasthenia gravis (MG) after a third Nivo infusion. Patient concerns: A 65-year-old man with advanced squamous cell lung carcinoma developed ptosis, diplopia, drop head, and general weakness 5 days after a third Nivo infusion. Diagnoses, interventions, and outcomes: We diagnosed him with Nivo-related MG and myositis based on clinical symptoms, elevation of muscle enzymes, negativity for autoantibodies and exclusion of other diagnoses. Steroid treatment with methylprednisolone 1 mg/kg/d and pyridostigmine 60 mg twice a day was administered beginning at admission; however, the patient's condition progressively worsened, despite treatment. Respiratory failure developed 2 weeks after admission, and his family declined the use of a mechanical ventilator. The patient died on day 27 after the third Nivo infusion. Lessons: Nivo-related MG should be highly suspected in patients who develop ptosis, diplopia, and general weakness. The corresponding treatments include discontinuation of Nivo and steroid treatment with plasmapheresis. The disease course may be rapid and fatal. This report stresses the importance of awareness of this rare and lethal adverse effect while using nivolomab immunotherapy.
Grain growth predictions in microalloyed steels

Empirical models for grain growth predictions are briefly reviewed. It is demonstrated that such models are inadequate for quantitative prediction of austenite grain growth during reheating of as-cast micro-structures in microalloyed steels. This inadequacy is mainly attributable to the inability of empirical models to account for abnormal grain growth. Basic principles of grain growth are therefore revisited in an attempt to develop a mathematical model which can account for abnormal grain growth. Such a model has been developed for Ti : N balanced microalloyed steels and is presented here. It is shown that quantitative pre- dictions of austenite grain growth generated from this model fit well with experimental grain growth data obtained during reheating of as-cast slabs of Ti. Ti + Nb as well as Ti + Nb + Mo containing microalloyed steels.
Reassortment and Mutations Associated with Emergence and Spread of Oseltamivir-Resistant Seasonal Influenza A/H1N1 Viruses in 2005–2009

A dramatic increase in the frequency of the H275Y mutation in the neuraminidase (NA), conferring resistance to oseltamivir, has been detected in human seasonal influenza A/H1N1 viruses since the influenza season of 2007–2008. The resistant viruses emerged in the ratio of 14.3% and quickly reached 100% in Taiwan from September to December 2008. To explore the mechanisms responsible for emergence and spread of the resistant viruses, we analyzed the complete genome sequences of 25 viruses collected during 2005–2009 in Taiwan, which were chosen from various clade viruses, 1, 2A, 2B-1, 2B-2, 2C-1 and 2C-2 by the classification of hemagglutinin (HA) sequences. Our data revealed that the dominant variant, clade 2B-1, in the 2007–2008 influenza emerged through an intra-subtype 4+4 reassortment between clade 1 and 2 viruses. The dominant variant acquired additional substitutions, including A206T in HA, H275Y and D354G in NA, L30R and H41P in PB1-F2, and V411I and P453S in basic polymerase 2 (PB2) proteins and subsequently caused the 2008–2009 influenza epidemic in Taiwan, accompanying the widespread oseltamivir-resistant viruses. We also characterized another 3+5 reassortant virus which became double resistant to oseltamivir and amantadine. Comparison of oseltamivir-resistant influenza A/H1N1 viruses belonging to various clades in our study highlighted that both reassortment and mutations were associated with emergence and spread of these viruses and the specific mutation, H275Y, conferring to antiviral resistance, was acquired in a hitch-hiking mechanism during the viral evolutionary processes.
The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway*♦

Amyloidogenic processing of the amyloid precursor protein (APP) by β- and γ-secretases generates several biologically active products, including amyloid-β (Aβ) and the APP intracellular domain (AICD). AICD regulates transcription of several neuronal genes, especially the Aβ-degrading enzyme, neprilysin (NEP). APP exists in several alternatively spliced isoforms, APP695, APP751, and APP770. We have examined whether each isoform can contribute to AICD generation and hence up-regulation of NEP expression. Using SH-SY5Y neuronal cells stably expressing each of the APP isoforms, we observed that only APP695 up-regulated nuclear AICD levels (9-fold) and NEP expression (6-fold). Increased NEP expression was abolished by a β- or γ-secretase inhibitor but not an α-secretase inhibitor. This correlated with a marked increase in both Aβ1–40 and Aβ1–42 in APP695 cells as compared with APP751 or APP770 cells. Similar phenomena were observed in Neuro2a but not HEK293 cells. SH-SY5Y cells expressing the Swedish mutant of APP695 also showed an increase in Aβ levels and NEP expression as compared with wild-type APP695 cells. Chromatin immunoprecipitation revealed that AICD was associated with the NEP promoter in APP695, Neuro2a, and APPSwe cells but not APP751 nor APP770 cells where AICD was replaced by histone deacetylase 1 (HDAC1). AICD occupancy of the NEP promoter was replaced by HDAC1 after treatment of the APP695 cells with a β- but not an α-secretase inhibitor. The increased AICD and NEP levels were significantly reduced in cholesterol-depleted APP695 cells. In conclusion, Aβ and functional AICD appear to be preferentially synthesized through β-secretase action on APP695.
A Unified RGB-T Saliency Detection Benchmark: Dataset, Baselines, Analysis and A Novel Approach

Despite significant progress, image saliency detection still remains a challenging task in complex scenes and environments. Integrating multiple different but complementary cues, like RGB and Thermal (RGB-T), may be an effective way for boosting saliency detection performance. The current research in this direction, however, is limited by the lack of a comprehensive benchmark. This work contributes such a RGB-T image dataset, which includes 821 spatially aligned RGB-T image pairs and their ground truth annotations for saliency detection purpose. The image pairs are with high diversity recorded under different scenes and environmental conditions, and we annotate 11 challenges on these image pairs for performing the challenge-sensitive analysis for different saliency detection algorithms. We also implement 3 kinds of baseline methods with different modality inputs to provide a comprehensive comparison platform. With this benchmark, we propose a novel approach, multi-task manifold ranking with cross-modality consistency, for RGB-T saliency detection. In particular, we introduce a weight for each modality to describe the reliability, and integrate them into the graph-based manifold ranking algorithm to achieve adaptive fusion of different source data. Moreover, we incorporate the cross-modality consistent constraints to integrate different modalities collaboratively. For the optimization, we design an efficient algorithm to iteratively solve several subproblems with closed-form solutions. Extensive experiments against other baseline methods on the newly created benchmark demonstrate the effectiveness of the proposed approach, and we also provide basic insights and potential future research directions for RGB-T saliency detection.
The molecular basis for the recognition of misfolded glycoproteins by the UDP‐Glc:glycoprotein glucosyltransferase.

The UDP‐Glc:glycoprotein glucosyltransferase is a soluble enzyme of the endoplasmic reticulum that glucosylates protein‐linked Man7–9GlcNAc2 to form the monoglucosylated derivatives. In vivo the reaction products are immediately deglucosylated by glucosidase II. The glucosyltransferase has a unique property: it glucosylates misfolded, but not native, glycoproteins. It has been proposed that the glucosyltransferase participates, together with calnexin, in the control mechanism by which only properly folded glycoproteins can exit from the endoplasmic reticulum. In this paper it is demonstrated that the glucosyltransferase recognizes two elements in the acceptor substrates: the innermost N‐acetylglucosamine unit of the oligosaccharide and protein domains exposed in denatured, but not in native, conformations. Both determinants have to be covalently linked. In many cases the first element is not accessible to macromolecular probes in native conformations. Concerning the protein domains, it is demonstrated here that the glucosyltransferase interacts with hydrophobic amino acids exposed in denatured conformations. More disordered conformations, i.e. those exposing more hydrophobic amino acids, were found to be those having higher glucose acceptor capacity. It is suggested that both accessibility of the innermost N‐acetylglucosamine unit and binding to hydrophobic patches determine the exclusive glucosylation of misfolded conformations by the glucosyltransferase.