Miracle-dz/UniFAR-FTUs huggingface dataset:
Young Children's Harmonic Perception

Abstract: Harmony and tonality are two of the most difficult elements for young children to perceive and manipulate and are seldom taught in the schools until the end of early childhood. Children's gradual harmonic and tonal development has been attributed to their cumulative exposure to Western tonal music and their increasing experiential knowledge of its rules and principles. Two questions that are relevant to this problem are: (1) Can focused and systematic teaching accelerate the learning of the harmonic/tonal principles that seem to occur in an implicit way throughout childhood? (2) Are there cognitive constraints that make it difficult for young children to perceive and/or manipulate certain harmonic and tonal principles? A series of studies specifically addressed the first question and suggested some possible answers to the second one. Results showed that harmonic instruction has limited effects on children's perception of harmony and indicated that the drastic improvement in the perception of implied harmony noted approximately at age 9 is due to development rather than instruction. I propose that young children's difficulty in perceiving implied harmony stems from their attention behaviors. Older children have less memory constraints and more strategies to direct their attention to the relevant cues of the stimulus. Younger children focus their attention on the melody, if present in the stimulus, and specifically on its concrete elements such as rhythm, pitch, and contour rather than its abstract elements such as harmony and key. The inference of the abstract harmonic organization of a melody required in the perception of implied harmony is thus an elusive task for the young child.
The induction of macrophage spreading: role of coagulation factors and the complement system

Unstimulated mouse peritoneal macrophages, attached to either glass or plastic substrates, responded to factors generated in serum and plasma by spreading and increasing their apparent surface area up to eightfold. Two distinct and dissociable systems were involved. The first appears related to the distinct and dissociable systems were involved. The first appears related to the contact phase of blood coagulation. It is activated by glass and not plastic surfaces, depleted by kaolin adsorption, and inhibited by soybean trypsin inhibitor. In contrast, a separate complement-dependent system can be generated in kaolin-adsorbed plasma. Activation of the complement system can occur either by the alternate or classical pathways and generates a relatively small effector molecule which is dialyzable. These factors presumably influencing the surface membrane and underlying structures may explain the rapid spreading of activated macrophages observed after both infections and chemical peritoneal inflammatory agents.
Tulbaghia violacea and Allium ursinum Extracts Exhibit Anti-Parasitic and Antimicrobial Activities

Garlic has played an important role in culinary arts and remedies in the traditional medicine throughout human history. Parasitic infections represent a burden in the society of especially poor countries, causing more than 1 billion infections every year and leading to around one million deaths. In this study, we investigated the mode of anti-parasitic activity of “wild garlics” Tulbaghia violacea and Allium ursinum dichloromethane extracts against parasites Trypanosoma brucei brucei and Leishmania tarentolae with regard to their already known antimicrobial activity. We also evaluated their cytotoxic potential against human cells. Both extracts showed a relevant trypanocidal and leishmanicidal activity, although L. tarentolae was less sensitive. We determined that the probable mode of action of both extracts is the irreversible inhibition of the activity of Trypanosoma brucei trypanothione reductase enzyme. The extracts showed a mild cytotoxic activity against human keratinocytes. They also exhibited weak—in most cases comparable—antibacterial and antifungal activity. HPLC-MS/MS analysis showed that both extracts are abundant in sulfur compounds. Thus, for the first time, the ability of Allium ursinum and Tulbaghia violacea to kill Trypanosoma sp. and Leishmania sp. parasites, probably by binding to and inactivating sulfur-containing compounds essential for the survival of the parasite, is shown.
Salmonella Biofilm Formation on Aspergillus niger Involves Cellulose – Chitin Interactions

Salmonella cycles between host and nonhost environments, where it can become an active member of complex microbial communities. The role of fungi in the environmental adaptation of enteric pathogens remains relatively unexplored. We have discovered that S. enterica Typhimurium rapidly attaches to and forms biofilms on the hyphae of the common fungus, Aspergillus niger. Several Salmonella enterica serovars displayed a similar interaction, whereas other bacterial species were unable to bind to the fungus. Bacterial attachment to chitin, a major constituent of fungal cell walls, mirrored this specificity. Pre-incubation of S. Typhimurium with N-acetylglucosamine, the monomeric component of chitin, reduced binding to chitin beads by as much as 727-fold and inhibited attachment to A. niger hyphae considerably. A cellulose-deficient mutant of S. Typhimurium failed to attach to chitin beads and to the fungus. Complementation of this mutant with the cellulose operon restored binding to chitin beads to 79% of that of the parental strain and allowed for attachment and biofilm formation on A. niger, indicating that cellulose is involved in bacterial attachment to the fungus via the chitin component of its cell wall. In contrast to cellulose, S. Typhimurium curli fimbriae were not required for attachment and biofilm development on the hyphae but were critical for its stability. Our results suggest that cellulose–chitin interactions are required for the production of mixed Salmonella-A. niger biofilms, and support the hypothesis that encounters with chitinaceous alternate hosts may contribute to the ecological success of human pathogens.
Coexistence of Burkholderia, Cupriavidus, and Rhizobium sp. Nodule Bacteria on two Mimosa spp. in Costa Rica

ABSTRACT rRNA gene sequencing and PCR assays indicated that 215 isolates of root nodule bacteria from two Mimosa species at three sites in Costa Rica belonged to the genera Burkholderia, Cupriavidus, and Rhizobium. This is the first report of Cupriavidus sp. nodule symbionts for Mimosa populations within their native geographic range in the neotropics. Burkholderia spp. predominated among samples from Mimosa pigra (86% of isolates), while there was a more even distribution of Cupriavidus, Burkholderia, and Rhizobium spp. on Mimosa pudica (38, 37, and 25% of isolates, respectively). All Cupriavidus and Burkholderia genotypes tested formed root nodules and fixed nitrogen on both M. pigra and M. pudica, and sequencing of rRNA genes in strains reisolated from nodules verified identity with inoculant strains. Inoculation tests further indicated that both Cupriavidus and Burkholderia spp. resulted in significantly higher plant growth and nodule nitrogenase activity (as measured by acetylene reduction assays) relative to plant performance with strains of Rhizobium. Given the prevalence of Burkholderia and Cupriavidus spp. on these Mimosa legumes and the widespread distribution of these plants both within and outside the neotropics, it is likely that both β-proteobacterial genera are more ubiquitous as root nodule symbionts than previously believed.
Weighted Conditional Random Fields for Supervised Interpatient Heartbeat Classification

This paper proposes a method for the automatic classification of heartbeats in an ECG signal. Since this task has specific characteristics such as time dependences between observations and a strong class unbalance, a specific classifier is proposed and evaluated on real ECG signals from the MIT arrhythmia database. This classifier is a weighted variant of the conditional random fields classifier. Experiments show that the proposed method outperforms previously reported heartbeat classification methods, especially for the pathological heartbeats.
Les Determinants «Traditionnels» De La Performance Des Conseils D'Administration Ont-Il Encore Du Sens Dans Les Pme ?: Une Etude Exploratoire Dans Le Contexte Français

Supported by agency theory, boards of directors (BD) performance was largely associated with the traditional determinants called usual suspects (size, independence and duality). The cognitive theories bring arguments being able to refute this association. The aim of this paper is to put forward the existence of other types of variables implying the BD performance. Indeed, on a sample of 123 French SME, results show that this latter is not associated with usual suspect determinants but rather with variables concerned with administrators competences as well as the board management.
A High Prevalence of Consanguineous and Severe Congenital Hypothyroidism in an Iranian Population

To determine the incidence of permanent congenital hypothyroidism (CH) in Tehran and Damavand, cord blood spots were collected from February 1998-August 2002 and infants with TSH > or =20 mU/l were recalled. CH was confirmed in neonates (aged > or =7 days) with serum TSH >10 mU/l and T4 <84 nmol/l. Cases were followed up until September 2003. Dysgenesis was detected by thyroid imaging. In eutopic cases, serum TSH and T4 measurements following levothyroxine discontinuation (2-3 years of age) confirmed dyshormonogenesis and transient CH. Of 35,067 neonates, 373 (1.06%) were recalled and 25 (1:1,403 births) had permanent CH (six had transient CH and four remain unknown). Dysgenesis was detected in 18 (1:1,948 births) and dyshormonogenesis in seven (1:5,010 births) infants. Parental consanguinity was present in 10 (55.6%) dysgenetic, three (42.9%) dyshormonogenetic, and overall 6,648 (28.6%) of 23,227 screened infants. Odds ratio (95%CI(OR)) of consanguinity in permanent CH and dysgenesis was 2.75 (1.17-6.47) and 3.74 (1.33-10.52), respectively. The high prevalence of parental consanguinity in infants with permanent CH warrants genetic assessment.
The effects of situational goal orientation and cultural learning values on team performance and adaptation to change

In this paper, we examine the unique effects of situational goal orientation and cultural learning values on team adaptation to change and the moderating role of cultural learning values in the relationship between goal orientation and team performance and adaptation. To do this, we conducted an experiment using a 2 × 2 × 2 repeated-measures factorial design, consisting of high and low levels of learning values, situational goal orientation (i.e., learning goals and performance goals). The experimental task involved two phases: we looked at team performance in Phase 1 and team adaptation to change in Phase 2. Forty 3-person teams were randomly assigned to four experimental conditions and all teams engaged in a complex bridge-planning task. Performance was measured in terms of the quality of the planned bridge. Results showed independent effects of situational goal orientation and cultural learning values on team performance and adaptation to change. Cultural learning values also moderated the relationship between goal orientation and performance and adaptation to change. Finally, the combination of learning goals and high learning values resulted in the highest levels of initial team performance (Phase 1) and adaptation to change and improved performance (Phase 2), as compared to all other examined conditions.
Análisis de la estructura factorial del test Pata Negra

The aim of this work is to analize the factor structure underlying Corman's test Patte Noire. We tested 98 children of the countryside of Guipuzcoa, following the author's critheria. Children's answers were clasified in 20 cathegories wich were found in the stories told by them. This answer cathegories had to pass the blind judge test. Acord porcentages among four judges varied from 0.62 to 1.00. Factor analysis was performed on this cathegories using the SPSS/PC+ program, and the following eight factor came out: frustrating mother, deffending mother/father form danger, orality, authority, agresivity of the parental fidgures, substitutive mother/father, ludic relation with mother/father, and agresivity directed against the father. Those factors proved to be related to the preferences of children toward mother or father in mildly stress situation, evaluated through cuestionary, and the attitudes and decision capacity of mothers.
Long non‐coding RNAs in corticogenesis: deciphering the non‐coding code of the brain

Evidence on the role of long non‐coding (lnc) RNAs has been accumulating over decades, but it has been only recently that advances in sequencing technologies have allowed the field to fully appreciate their abundance and diversity. Despite this, only a handful of lncRNAs have been phenotypically or mechanistically studied. Moreover, novel lncRNAs and new classes of RNAs are being discovered at growing pace, suggesting that this class of molecules may have functions as diverse as protein‐coding genes. Interestingly, the brain is the organ where lncRNAs have the most peculiar features including the highest number of lncRNAs that are expressed, proportion of tissue‐specific lncRNAs and highest signals of evolutionary conservation. In this work, we critically review the current knowledge about the steps that have led to the identification of the non‐coding transcriptome including the general features of lncRNAs in different contexts in terms of both their genomic organisation, evolutionary origin, patterns of expression, and function in the developing and adult mammalian brain.
Functional Screening Identifies miRNAs Influencing Apoptosis and Proliferation in Colorectal Cancer

MicroRNAs (miRNAs) play a critical role in many biological processes and are aberrantly expressed in human cancers. Particular miRNAs function either as tumor suppressors or oncogenes and appear to have diagnostic and prognostic significance. Although numerous miRNAs are dys-regulated in colorectal cancer (CRC) only a small fraction has been characterized functionally. Using high-throughput functional screening and miRNA profiling of clinical samples the present study aims at identifying miRNAs important for the control of cellular growth and/or apoptosis in CRC. The high-throughput functional screening was carried out in six CRC cell lines transfected with a pre-miR library including 319 synthetic human pre-miRs. Phenotypic alterations were evaluated by immunostaining of cleaved cPARP (apoptosis) or MKI67 (proliferation). Additionally, TaqMan Human MicroRNA Array Set v2.0 was used to profile the expression of 667 miRNAs in 14 normal colon mucosa and 46 microsatellite stable stage II CRC patients. Among the miRNAs that induced growth arrest and apoptosis in the CRC cell lines, and at same time were dys-regulated in the clinical samples, miR-375 was selected for further analysis. Independent in vitro analysis of transient and stable transfected CRC cell lines confirmed that miR-375 reduces cell viability through the induction of apoptotic death. We identified YAP1 as a direct miR-375 target in CRC and show that HELLS and NOLC1 are down-stream targets. Knock-down of YAP1 mimicked the phenotype induced by miR-375 over-expression indicating that miR-375 most likely exerts its pro-apoptotic role through YAP1 and its anti-apoptotic down-stream targets BIRC5 and BCL2L1. Finally, in vivo analysis of mouse xenograft tumors showed that miR-375 expression significantly reduced tumor growth. We conclude that the high-throughput screening successfully identified miRNAs that induce apoptosis and/or inhibit proliferation in CRC cells. Finally, combining the functional screening with profiling of CRC tissue samples we identified clinically relevant miRNAs and miRNA targets in CRC.
The melancholy of race

In this groundbreaking, interdisciplinary study Anne A. Cheng argues that we have to understand racial grief not only as the result of racism but also as a foundation for racial identity. She proposes that racial identification is itself already a melancholy act - a social category that is imaginatively supported through a dynamic of loss and compensation, by which the racial other is at once rejected and retained, denigrated and idealized. Drawing upon history, literature and theatre - the book ranges from Rodgers and Hammerstein to David Henry Whang, Brown v. Board of Education to Anne Deveare Smith, Ralph Ellison to Maxine Hong Kingston - Cheng demonstrates that racial melancholia permeates our fantasies of citizenship, assimilation, and social health. A provocative look at a timely cultural dilemma, this study is essential reading for anyone interested in race studies, critical theory, or psychoanalysis.
Modeling and compensation of nonlinearities and friction in a micro hard disk drive servo system with nonlinear feedback control

Friction and nonlinearities result in large residual errors and deteriorate the performance of head positioning of hard disk drive (HDD) servo systems and other mechanical servo systems. Thus, it is highly desirable to characterize the behaviors of nonlinearities and friction in the servo systems. This paper presents a fairly comprehensive modeling and compensation of friction and nonlinearities of a typical voice-coil-motor (VCM) actuator used in commercial HDDs, and the design of an HDD servo system using an enhanced nonlinear control technique. Our contributions are two-fold: We will first obtain a complete model of the VCM actuator including friction and nonlinear characteristics through a careful examination of the configuration and structure of the actual system and through a thorough analysis of its physical effects together with its time-domain and frequency-domain responses. We will then proceed to design a servo system for the hard drive using an enhanced composite nonlinear feedback (CNF) control technique with a simple friction and nonlinearity compensation scheme. The enhanced CNF technique has a feature of removing the uncompensated portion of friction and nonlinearities without sacrificing the overall tracking performance. Simulation and experimental results for both the modeling and the servo design show that our approach is very effective and successful. In particular, our experimental results show that the enhanced CNF control has outperformed the conventional proportional-integral-derivative (PID) control in settling time by 76%. We believe that this approach can be adopted to solve other servomechanism problems.
Clustering with Deep Learning: Taxonomy and New Methods

Clustering is a fundamental machine learning method. The quality of its results is dependent on the data distribution. For this reason, deep neural networks can be used for learning better representations of the data. In this paper, we propose a systematic taxonomy for clustering with deep learning, in addition to a review of methods from the field. Based on our taxonomy, creating new methods is more straightforward. We also propose a new approach which is built on the taxonomy and surpasses some of the limitations of some previous work. Our experimental evaluation on image datasets shows that the method approaches state-of-the-art clustering quality, and performs better in some cases.
Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice

There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. In our diet intervention study, C57BL/6J mice were fed high-fat diets differing in Ca concentrations (50 v. 150 mmol/kg). Faecal excretion analyses showed an elevated precipitation of intestinal fatty acids (2·3-fold; P < 0·01) and bile acids (2-fold; P < 0·01) on the high-Ca diet. However, this only led to a slight reduction in fat absorption (from 98 to 95 %; P < 0·01), mainly in the distal small intestine as indicated by gene expression changes. We found no effect on body-weight gain. Lipolysis and lipogenesis-related parameters in adipose tissue also showed no significant changes on the high-Ca diet, indicating no systemic effects of dietary Ca on adiposity. Furthermore, early gene expression changes of intestinal signalling molecules predicted no protective effect of dietary Ca on the development of insulin resistance, which was confirmed by equal values for insulin sensitivity on both diets. Taken together, our data do not support the proposed protective effect of dietary Ca on the development of obesity and/or insulin resistance, despite a significant increase in faecal excretion of fatty acids and bile acids.
Measurement and Application of Egoistic and Moralistic Self‐Enhancement

Five studies were conducted to develop and validate the Egoistic and Moralistic Self-enhancement (EMS) scale, a new self-report measure of egoistic and moralistic self-enhancement. Exploratory and confirmatory factor analysis provided evidence for a two-factor structure comprising the tendencies to promote agentic (egoistic) and communal (moralistic) qualities (Study 1). Construct validity was supported by significant correlations with established measures of socially desirable responding, such as the Balanced Inventory of Desirable Responding (Study 2) and the Impression Management scale of the 16 Personality Factors (Study 3). When the EMS scale has been applied in organizational settings, we found that job applicants were more inclined than nonapplicants to promote their own agentic and communal qualities, although differences were more pronounced for egoistic self-enhancement (Study 4). Findings also suggested that exaggeration of agentic qualities decrease the criterion-related validity of conscientiousness in predicting job performance (Study 5). Taken together, findings suggest that the EMS scale provides a valid and reliable measure that can be fruitfully used for both theoretical and applied research.
Maternal behavior of beef cows at parturition.

Over an 11-yr period maternal behavior, calf birth weight and calf condition were recorded within 24 h for 2,684 parturitions. Maternal behavior was rated on a scale from 1 to 11, where 1 indicated extreme aggressiveness and 11 indicated no maternal attentiveness. Birth condition was rated on a scale from 1 to 9, with 9 being fattest and 1 thinnest. Respective breed means of Hereford, Angus, Charolais and Red POll were 6.2, 5.3, 6.0, and 5.7 for maternal behavior rating; 30.6, 27.3, 39.2 and 32.6 kg for birth weight, and 5.5, 4.7, 5.6 and 5.5 for birth condition. Heritability estimates for maternal rating, birth weight and birth condition were . 06 +/- . 01, . 48 +/- . 02 and . 19 +/- . 01, respectively. Genetic correlations between maternal rating and birth weight and condition were . 04 +/- . 05 and -. 02 +/- . 06, respectively. These results suggest that, in the population of cows studied, nongenetic influences were the primary cause of differences in aggressiveness of cows at parturition.