Miracle-dz/UniFAR-FTUs huggingface dataset:
Is spacing really the “friend of induction”?

Inductive learning takes place when people learn a new concept or category by observing a variety of exemplars. Kornell and Bjork (2008) asked participants to learn new painting styles either by presenting different paintings of the same artist consecutively (massed presentation) or by mixing paintings of different artists (spaced presentation). In their second experiment, Kornell and Bjork (2008) showed with a final style recognition test, that spacing resulted in better inductive learning than massing. Also, by using this style recognition test, they ruled out the possibility that spacing merely resulted in a better memory for the labels of the newly learned painting styles. The findings from Kornell and Bjork’s (2008) second experiment are important because they show that the benefit of spaced learning generalizes to complex learning tasks and outcomes, and that it is not confined to rote memory learning. However, the findings from Kornell and Bjork’s (2008) second experiment have never been replicated. In the present study we performed an exact and high-powered replication of Kornell and Bjork’s (2008) second experiment with a Web-based sample. Such a replication contributes to establish the reliability of the original finding and hence to more conclusive evidence of the spacing effect in inductive learning. The findings from the present replication attempt revealed a medium-sized advantage of spacing over massing in inductive learning, which was comparable to the original effect in the experiment by Kornell and Bjork (2008). Also, the 95% confidence intervals (CI) of the effect sizes from both experiments overlapped considerably. Hence, the findings from the present replication experiment and the original experiment clearly reinforce each other.
The nature of facial expression recognition deficits following orbitofrontal cortex damage.

OBJECTIVE Orbitofrontal cortex (OFC) damage has been associated with facial expression recognition deficits in some, but not all, previous studies. The pattern of performance of a group of patients with OFC damage was assessed across a series of facial expression recognition tasks. We aimed to determine whether some tasks were more sensitive at detecting deficits than others. METHOD Seven patients with damage to the OFC, 6 control patients with frontal lesions that spared the OFC, and a group of healthy controls completed a series of facial expression recognition tasks including 2 labeling tasks and 2 matching tasks. RESULTS The OFC patient group demonstrated impaired labeling of negative facial expressions (i.e., anger, disgust, fear, and sadness) shown for a short time (500 ms) relative to the comparison groups. When facial expressions were shown for a longer time (5,000 ms), the OFC patient group's performance did not differ significantly from either comparison group. The OFC patient group was impaired when matching subtle, low intensity negative facial expressions, but not when matching high intensity, prototypical facial expressions. CONCLUSIONS The pattern of performance across tasks revealed that only certain facial expression recognition tasks appear to be sufficiently sensitive to detect deficits in patients with OFC damage. These findings have important implications for the assessment of facial expression recognition difficulties in patients with OFC damage and more broadly, for special populations.
Regulation of IRSp53-Dependent Filopodial Dynamics by Antagonism between 14-3-3 Binding and SH3-Mediated Localization

ABSTRACT Filopodia are dynamic structures found at the leading edges of most migrating cells. IRSp53 plays a role in filopodium dynamics by coupling actin elongation with membrane protrusion. IRSp53 is a Cdc42 effector protein that contains an N-terminal inverse-BAR (Bin-amphipysin-Rvs) domain (IRSp53/MIM homology domain [IMD]) and an internal SH3 domain that associates with actin regulatory proteins, including Eps8. We demonstrate that the SH3 domain functions to localize IRSp53 to lamellipodia and that IRSp53 mutated in its SH3 domain fails to induce filopodia. Through SH3 domain-swapping experiments, we show that the related IRTKS SH3 domain is not functional in lamellipodial localization. IRSp53 binds to 14-3-3 after phosphorylation in a region that lies between the CRIB and SH3 domains. This association inhibits binding of the IRSp53 SH3 domain to proteins such as WAVE2 and Eps8 and also prevents Cdc42-GTP interaction. The antagonism is achieved by phosphorylation of two related 14-3-3 binding sites at T340 and T360. In the absence of phosphorylation at these sites, filopodium lifetimes in cells expressing exogenous IRSp53 are extended. Our work does not conform to current views that the inverse-BAR domain or Cdc42 controls IRSp53 localization but provides an alternative model of how IRSp53 is recruited (and released) to carry out its functions at lamellipodia and filopodia.
A Lateral Flow-Based Ultra-Sensitive p24 HIV Assay Utilizing Fluorescent Microparticles

The current demand for HIV diagnostic tests in resource-limited settings is not being fully addressed by the currently available nucleic acid test or enzyme-linked immunosorbent assay-based p24 antigen assays. This is primarily due to their high cost, their requirement for controlled laboratory conditions and/or personnel, or the relatively long turn-around time for test results. Self performing lateral flow assays address all of these issues but to date have not reached the level of analytical sensitivity for HIV p24 demonstrated by current generation enzyme-linked immunosorbent assay technology. This report presents an initial prototype lateral flow assay for HIV p24 antigen capable of achieving subpicogram per milliliter limits of analytical sensitivity and requiring less than 40 minutes to yield results.
Assessment of a cytomegalovirus serology dual‐testing strategy in hematopoietic stem cell transplant recipients

Accurate determination of recipient cytomegalovirus (CMV) serostatus before allogeneic hematopoietic stem cell transplantation (HSCT) is critical, as it is the most important predictor of post‐transplant CMV infection and remains associated with non‐relapse mortality. The purpose of this study was to assess a recipient dual‐testing strategy before HSCT.
Exploiting Subgraph Structure in Multi-Robot Path Planning

Multi-robot path planning is dificult due to the combinatorial explosion of the search space with every new robot added. Complete search of the combined state-space soon becomes intractable. In this paper we present a novel form of abstraction that allows us to plan much more eficiently. The key to this abstraction is the partitioning of the map into subgraphs of known structure with entry and exit restrictions which we can represent compactly. Planning then becomes a search in the much smaller space of subgraph configurations. Once an abstract plan is found, it can be quickly resolved into a correct (but possibly sub-optimal) concrete plan without the need for further search. We prove that this technique is sound and complete and demonstrate its practical effiectiveness on a real map. A contending solution, prioritised planning, is also evaluated and shown to have similar performance albeit at the cost of completeness. The two approaches are not necessarily conflicting; we demonstrate how they can be combined into a single algorithm which out-performs either approach alone.
Diabetes education for children with type 1 diabetes mellitus and their families.

OBJECTIVES To determine the effectiveness of diabetes education on metabolic control, diabetes-related hospitalizations, complications, and knowledge, quality of life and other psychosocial outcomes for children with type 1 diabetes and their families. DATA SOURCES A systematic and comprehensive literature review was conducted in 21 electronic databases of medical and health education literature to identify randomized controlled trials (RCTs) and observational studies evaluating the effectiveness of diabetes education. REVIEW METHODS Study selection, quality assessment, and data extraction were conducted independently by several investigators in duplicate. A descriptive analysis is presented. RESULTS From 12,756 citations, 80 studies were identified and included in the review (53 RCTs or CCTs, 27 observational studies). The methodological quality of studies was generally low. Most studies (35/52) that examined the effect of educational interventions on HbA1c found no evidence of increased effectiveness of the interventions over the education provided as part of standard care. Successful interventions were heterogeneous and included cognitive behavioral therapy, family therapy, skills training and general diabetes education. Most studies reported a positive effect on health service utilization (i.e., reduced use), although less than half were statistically significant. There was no clear evidence that educational interventions had an effect on short-term complications. The effect of educational interventions on diabetes knowledge was unclear with 12/30 studies reporting a significant improvement. Interventions which had varying effects on knowledge scores included diabetes camp, general diabetes education, and cognitive behavioral therapy. In the area of self management/regimen adherence, 10/21 studies reported improving this outcome significantly. Successful interventions included general diabetes education and cognitive behavioral therapy. Educational interventions were successful in improving various psychosocial outcomes. The results of two studies examining refinements to intensive therapy education suggest that educational interventions may enhance the effects of intensive diabetes management in reducing HbA1c. CONCLUSIONS Due to the heterogeneity of reported diabetes education interventions, outcome measures, and duration of followup, there is insufficient evidence to identify a particular intervention that is more effective than standard care to improve diabetes control or quality of life or to reduce short-term complications.
Pharmacogenetics of drug‐induced liver injury

Recent progress in research on drug‐induced liver injury (DILI) has been determined by key developments in two areas. First, new technologies allow the identification of genetic risk factors with improved sensitivity, specificity, and efficiency. Second, new mechanistic concepts of DILI emphasize the importance of unspecific “downstream” events following drug‐specific initial “upstream” hepatocyte injury and of complex interactions between environmental and genetic risk factors. The integration of genetic and mechanistic concepts is essential for current research approaches, and genetic studies of DILI now focus on targets that affect the function and transcriptional regulation of genes relating not only to drug metabolism but also to human leukocyte antigens (HLAs), cytokines, oxidative stress, and hepatobiliary transporters. Risk factors affecting unspecific downstream mechanisms may be identified using pooled DILI cases caused by various drugs. The power to detect variants that confer a low risk can be increased by recruitment of strictly selected cases through large networks, whereas controls may also be obtained from genotyped reference populations. The first genomewide studies of DILI identified HLA variants as risk factors for hepatotoxicity associated with flucloxacillin and ximelagatran, and their design has defined a new standard for pharmacogenetic studies. From a clinical and regulatory point of view, there is a need for genetic tests that identify patients at increased hepatotoxic risk. However, DILI is a rare complex disease, and pharmacogenetic studies have so far not been able to identify interactions of several risk factors defining a high population‐attributable risk and clinically relevant absolute risk for DILI. (HEPATOLOGY 2010)
Influence of Bifidobacterium bifidum on Release of Minerals from Bread with Differing Bran Content

Bread is considered an important source of minerals; however, the presence of fiber and phytic acid reduces bioavailability of minerals from cereal products. It is well established that activity of microorganisms in human gut increases the amount of nutrients released during digestion. The aim of this study was to determine the influence of Bifidobacterium bifidum on release of some minerals from bread using an in vitro process of enzymatic digestion. White bread and with addition of 15, 30, or 45% of bran was baked in a bakery by traditional methods, with addition of yeasts and rye leaven, from flour made of wheat, Tonacja variety. Concentrations of calcium, magnesium, manganese, zinc, copper, and iron were determined by atomic absorption spectrometry. Bread was enzymatically digested in vitro without and with the addition of Bifidobacterium bifidum KD6 (inoculum 106 CFU/cm3) and percentages of minerals released were determined. The concentration of minerals released during enzymatic digestion varied depending upon the element, quantity of bran, and presence of bacteria. Increase in bran content decreased release of elements. Bifidobacterium bifidum KD6 enhanced amounts of magnesium and zinc released from all types of bread, while manganese and copper rose only from white bread with 15% bran addition. Bacteria decreased amounts of calcium and iron released from bread. Data indicate that diets rich in beneficial bacteria (probiotics) but not balanced with minerals might increase mineral deficiency.
Tenascin-C and integrins in cancer

Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes the epithelial-mesenchymal transition, proliferation, and migration of cancer cells. It also facilitates the formation of cancer stroma including desmoplasia and angiogenesis. Integrin receptors that mediate the signals of TNC have also been discussed.
The psychopharmacological management of eating disorders in children and adolescents

In this review we synthesised current literature on the psychopharmacological management of eating disorders (EDs) in children and adolescents (C&As). We focus specifically on anorexia nervosa (AN), bulimia nervosa (BN) and binge eating disorder (BED). The treatment of EDs is determined by physical and psycho-social factors and needs. Pharmacological management should therefore be viewed and incorporated as one component of a multi-disciplinary comprehensive treatment plan for specific requirements of a patient depending on the stage of the disorder. As there is a dearth of studies evaluating the use of psychopharmacology for EDs in C&As we first review the findings from studies performed in adults and then discuss specific studies performed in C&As. We include information from reviews and treatment guidelines to assist the clinician with an approach to the use of psychopharmacological agents in the treatment of EDs in C&As.
Fractional Contributions of the Right and Left Coronary Arteries to Perfusion of Normal and Hypertrophied Right Ventricles of Conscious Dogs

The extent to which the blood supply of normal and hypertrophied right ventricles originates from the right and left coronary arteries was investigated in conscious dogs. Right ventric-ular (RV) hypertrophy, induced by gradual, chronic (4-6 months) stenosis of the main pulmonary artery, was characterized by a 72% increase (P < 0.001) in RV weight to body weight ratio and a 106% increase (P < 0.001) in total RV transmural blood flow per gram (radioactive microsphere technique). In normal dogs, left main coronary artery occlusion (CAO) reduced blood flow only slightly to the central core of the RV free wall, but markedly (P < 0.001) to the peripheral zones. Right main CAO reduced blood flow in both RV central and peripheral zones to similar absolute levels in both normal animals and dogs with RV hypertrophy. Keeping in mind that pre-CAO control levels were greater in the presence of hypertrophy, the magnitude of the reduction in blood flow was significantly greater (P < 0.01) with right CAO in dogs with hypertrophy. Endocardial-epicardial perfusion ratios of both RV central and peripheral zones were significantly reduced (P < 0.02) both at rest and during right CAO in dogs with RV hypertrophy as compared to normal dogs with matched heart rates. These data indicate that the left coronary artery usually supplies a substantial fraction (∽37%) of total RV free wall perfusion in normal, conscious dogs. Moreover, it is seen that the marked, selective increases in transmural RV blood flow in RV hypertrophy are provided by the right but not the left coronary artery. Circ Res 47:190-200, 1980
A new 65nm LP metastability measurment test circuit

Recent synchronizer metastability measurements indicate degradation of MTBF with technology scaling, calling for measurement and calibration circuits in 65nm and beyond. Degradation of parameters can be even worse if the system is operated at extreme supply voltages and temperature conditions. In this work we study the behavior of synchronizers in a broad range of supply voltage and temperature corners. A digital on-chip measurement system is presented that helps to characterize synchronizers in future technologies and a new calibrating system to account for supply voltage and temperature changes is shown. Measurements are compared to simulations for a fabricated 65nm bulk CMOS circuit build.
The Effect of Lopinavir/Ritonavir and Darunavir/Ritonavir on the HIV Integrase Inhibitor S/GSK1349572 in Healthy Participants

S/GSK1349572 is an unboosted, once‐daily integrase inhibitor with a novel resistance profile. As standard of care for patients infected with HIV is combination therapy, the potential interaction between S/GSK1349572 and ritonavir‐boosted protease inhibitors was evaluated. In an open‐label, repeat‐dose, 2‐period, 2‐sequence crossover study in healthy participants, S/GSK1349572 was administered at 30 mg once daily for 5 days, followed by randomization to lopinavir/ritonavir 400/100 mg twice daily or darunavir/ritonavir 600/100 mg twice daily coadministered with S/GSK1349572 30 mg once daily for 14 days. There was no washout between periods. Serial pharmacokinetic (PK) samples and safety assessments were obtained throughout the study. Thirty of 31 participants completed the study (15 participants per group). Treatment comparisons of steady‐state S/GSK1349572 PK parameters demonstrated that coadministration of lopinavir/ritonavir had no significant effect on steady‐state PK of S/GSK1349572. Coadministration of darunavir/ritonavir resulted in a nonclinically significant reduction in steady‐state plasma S/GSK1349572 exposures. Plasma S/GSK1349572 AUC(0‐τ), Cmax, and Cτ decreased by 22%, 11%, and 38%, respectively, on average. S/GSK1349572 was well tolerated with no serious adverse events (AEs) or withdrawals due to drug‐related AEs. The most frequent drug‐related AEs were diarrhea, dizziness, and headache. No dosage adjustment for S/GSK1349572 is required when used with lopinavir/ritonavir or darunavir/ritonavir.
Reproducibility of dynamic contrast-enhanced MR imaging. Part I. Perfusion characteristics in the female pelvis by using multiple computer-aided diagnosis perfusion analysis solutions.

PURPOSE To test the reproducibility of model-derived quantitative and semiquantitative pharmacokinetic parameters among various commercially available perfusion analysis solutions for dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging. MATERIALS AND METHODS The study was institutional review board approved and HIPAA compliant, with waiver of informed consent granted. The study group consisted of 15 patients (mean age, 44 years; range, 28-60 years), with 15 consecutive 1.5-T DCE MR imaging studies performed between October 1, 2010, and December 27, 2010, prior to uterine fibroid embolization. Studies were conducted by using variable-flip-angle T1 mapping and four-dimensional, time-resolved MR angiography with interleaved stochastic trajectories. Images from all DCE MR imaging studies were postprocessed with four commercially available perfusion analysis solutions by using a Tofts and Kermode model paradigm. Five observers measured pharmacokinetic parameters (volume transfer constant [K(trans)], v(e) [extracellular extravascular volume fraction], k(ep)[K(trans)/v(e)], and initial area under the gadolinium curve [iAUGC]) three times for each imaging study with each perfusion analysis solution (between March 13, 2011, and September 8, 2011) by using two different region-of-interest methods, resulting in 1800 data points. RESULTS After normalization of data output, significant differences in mean values were found for the majority of perfusion analysis solution combinations. The within-subject coefficient of variation among perfusion analysis solutions was 48.3%-68.8% for K(trans), 37.2%-60.3% for k(ep), 27.7%-74.1% for v(e), and 25.1%-61.2% for iAUGC. The intraclass correlation coefficient revealed only poor to moderate consistency among pairwise perfusion analysis solution comparisons (K(trans), 0.33-0.65; k(ep), 0.02-0.81; v(e), -0.03 to 0.72; and iAUGC, 0.47-0.78). CONCLUSION A considerable variability for DCE MR imaging pharmacokinetic parameters (K(trans), k(ep), v(e), iAUGC) was found among commercially available perfusion analysis solutions. Therefore, clinical comparability across perfusion analysis solutions is currently not warranted. Agreement on a postprocessing standard is paramount prior to establishing DCE MR imaging as a widely incorporated biomarker.
Math information retrieval: user requirements and prototype implementation

We report on the user requirements study and preliminary implementation phases in creating a digital library that indexes and retrieves educational materials on math. We first review the current approaches and resources for math retrieval, then report on the interviews of a small group of potential users to properly ascertain their needs. While preliminary, the results suggest that meta-search and resource categorization are two basic requirements for a math search engine. In addition, we implement a prototype categorization system and show that the generic features work well in identifying the math contents from the webpage but perform less well at categorizing them. We discuss our long term goals, where we plan to investigate how math expressions and text search may be best integrated.
Impact Evaluation of a Cognitive Behavioral Group Therapy Model in Brazilian Sexually Abused Girls

This study evaluated the impact of a cognitive behavioral group therapy model in Brazilian girls who had experienced sexual abuse. The effect of the waiting period before treatment and the enduring effectiveness of the treatment after six and 12 months were also evaluated. Forty-nine female sexual abuse victims between the ages of 9 and 16 completed instruments measuring depression, anxiety, stress, and post-traumatic stress disorder before, during, and after the group therapy. The group therapy had a positive impact on their psychological functioning, significantly reducing symptoms of anxiety, stress, and post-traumatic stress disorder. The therapeutic effects lasted six to 12 months after the treatment ended. The model proved effective for treating young female victims of sexual abuse.