Miracle-dz/UniFAR-FTUs huggingface dataset:
Applicability of Homomorphic Encryption and CryptDB in Social and Business Applications: Securing Data Stored on the Third Party Servers while Processing through Applications

Confidentiality in third party services like cloud computing has become a major concern. IT industry and government organizations are very serious about security factor in cloud computing, because its usage has reached all the way from a common man having a mobile phone to large scale business enterprises. In this paper, we present security threats in social and business applications accessing the data stored in cloud computing scenario. Also, we critically discuss homomorphic encryption and CryptDB schemes which are applicable to protect data from malicious third party service environments (cloud computing) and also from insiders for these applications. We also present empirical results of partial homomorpic encryption algorithms over one lakh 10-digit numbers, using Linux virtual machine on VirtualBox, VMPlayer and KVM. The result for four algorithms (namely Paillier, ElGamal, RSA and Benaloh) as performed on the above four different platforms are computed to show their respective overhead values as compared to plain data operations. In case of Paillier Algorithm the overhead is 17, 15, 22 and 12 times for addition operation and 278, 399,518 and 346 times for multiplication operation respectively. Similarly, in case of Elgamal algorithm 1.72, 1.6, 11.7 and 8.9 times for multiplication operation; in case of RSA algorithm 1.79, 1.5, 3.48 and 1.5 times for multiplication operation and in case of Benaloh algorithm is 5.6, 5.36, 5.48 and 3.5 times for addition operation respectively. These performances clearly indicate that these algorithms are quite feasible enough to be used in context of social and business applications by third party service providers
Suitability of replacement markers for functional analysis studies inSaccharomyces cerevisiae

The complete yeast sequence contains a large proportion of genes whose biological function is completely unknown. One approach to elucidating the function of these novel genes is by quantitative methods that exploit the concepts of metabolic control analysis. An important first step in such an analysis is to determine the effects of deleting individual genes on the growth rate (or fitness) of Saccharomyces cerevisiae. Since the specific growth‐rate effects of most genes are likely to be small, they are most readily determined by competition against a standard strain in chemostat cultures where the true steady state demanded by metabolic control analysis may be achieved. We have constructed two different standard strains in which the HO gene is replaced by either HIS3 or kanMX. We demonstrate that HO is a selectively neutral site for gene replacement. However, there is a significant marker effect associated with HIS3 which, moreover, is dependent on the physiological conditions used for the competition experiments. In contrast, the kanMX marker exhibited only a small effect on specific growth rate (≤±4%). These data suggest that nutritional markers should not be used to generate deletion mutants for the quantitative analysis of gene function in yeast but that kanMX replacements may be used, with confidence, for such studies. © 1997 John Wiley & Sons, Ltd.
Drinking water biofilm assessment of total and culturable bacteria under different operating conditions

Abstract Monitoring of biofilms subjected to different operating conditions was performed using a flow cell system. The system was fed by chlorine-free tap water, with and without added nutrients (0.5 mg l−1 carbon, 0.1 mg l−1 nitrogen and 0.01 mg l−1 phosphorus), and biofilms were grown on polyvinyl chloride (PVC) and stainless steel (SS) coupons, both in laminar and turbulent flow. The parameters analysed were culturable cells, using R2A, and total bacteria, which was assessed using the 4,6-diamino-2-phenylindole (DAPI) staining method. The impact of the different operating conditions in the studied parameters was established using Multivariate Analysis of Variance (MANOVA). From the most relevant to the least relevant factor, the total and culturable bacteria in biofilms increased due to the addition of nutrients to water (F = 20.005; p < 0.001); the use of turbulent (Re = 11000) instead of laminar (Re = 2000) hydrodynamic flows (F = 9.173; p < 0.001); and the use of PVC instead of SS as the support material (F = 2.848; p = 0.060). Interactions between these conditions, namely between surface and flow (F = 8.235; p < 0.001) and also flow and nutrients (F = 5.498; p < 0.05) have also proved to significantly influence biofilm formation. This work highlights the need for a deeper understanding of how the large spectrum of conditions interact and affect biofilm formation potential and accumulation with the final purpose of predicting the total and culturable bacteria attached to real drinking water distribution pipes based on the system characteristics.
Prediction of future development of canine atopic dermatitis based on examination of clinical history.

OBJECTIVES The aim of this study was to identify clinical features that could be used to identify individual dogs within the Guide Dogs for the Blind Association canine population at risk of being diagnosed as atopic in the future before they had fully developed the condition. METHODS Clinical histories of atopic and non-atopic dogs from the Guide Dogs for the Blind Association population were analysed and statistically significant differences identified between the two groups. RESULTS Atopic dogs were consistently affected by skin disease at a younger age than non-atopic dogs and that there was a significant difference in event curves between atopic and non-atopic dogs at 10 months of age. From a predictive point of view, dogs that suffered from four or more episodes of atopic-type skin disease by the age of 15 months were at an increased risk of developing atopic dermatitis. CLINICAL SIGNIFICANCE It is suggested that the clinical history of all dogs from the Guide Dogs for the Blind Association about to undergo training should be examined for these factors to assess whether or not they should undergo training.
Cytoplasmic Compartmentation of Gln3 during Nitrogen Catabolite Repression and the Mechanism of Its Nuclear Localization during Carbon Starvation in Saccharomyces cerevisiae *

Regulated intracellular localization of Gln3, the transcriptional activator responsible for nitrogen catabolite repression (NCR)-sensitive transcription, permits Saccharomyces cerevisiae to utilize good nitrogen sources (e.g.glutamine and ammonia) in preference to poor ones (e.g. proline). During nitrogen starvation or growth in medium containing a poor nitrogen source, Gln3 is nuclear and NCR-sensitive transcription is high. However, when cells are grown in excess nitrogen, Gln3 is localized to the cytoplasm with a concomitant decrease in gene expression. Treating cells with the Tor protein inhibitor, rapamycin, mimics nitrogen starvation. Recently, carbon starvation has been reported to cause nuclear localization of Gln3 and increased NCR-sensitive transcription. Here we show that nuclear localization of Gln3 during carbon starvation derives from its indirect effects on nitrogen metabolism, i.e. Gln3 does not move into the nucleus of carbon-starved cells if glutamine rather than ammonia is provided as the nitrogen source. In addition, these studies have clearly shown Gln3 is not uniformly distributed in the cytoplasm, but rather localizes to punctate or tubular structures. Analysis of these images by deconvolution microscopy suggests that Gln3 is concentrated in or associated with a highly structured system in the cytosol, one that is possibly vesicular in nature. This finding may impact significantly on how we view (i) the mechanism by which Tor regulates the intracellular localization of Gln3 and (ii) how proteins move into and out of the nucleus.
The hepatitis C virus: Overview

Our knowledge of hepatitis C virus (HCV) dates only from 1975, when non‐ A, non‐B hepatitis was first recognized. It was not until 1989 that the genome of the virus was first cloned and sequenced, and expressed viral antigens used to develop serological assays for screening and diagnosis. HCV is in a separate genus of the virus family Flaviviridae. It is a spherical enveloped virus of approximately 50 nm in diameter. Its genome is a single‐stranded linear RNA molecule of positive sense and consists of a 5′ noncoding region, a single large open reading frame, and a 3′ noncoding region. The open reading frame encodes at least three structural and six nonstructural proteins. The genome is characterized by significant genetic heterogeneity, based on which HCV isolates can be classified into six major genotypes and more than 50 subtypes. Even individual isolates of HCV are genetically heterogeneous (quasispecies diversity). Genetic heterogeneity of HCV is greatest in the amino‐terminal end of the second envelope protein (hypervariable region 1). This region may represent a neutralization epitope that is under selective pressure from the host's humoral immune response. Infection with HCV proceeds to chronicity in more than 80% of cases, and even recovery does not protect against subsequent re‐exposure to the virus. The development of a broadly protective vaccine against HCV will therefore require a better understanding of the molecular biology and immune response to this virus.
The role of premotor interneurons in phase-dependent modulation of a cutaneous reflex during swimming in Xenopus laevis embryos

Phase-dependent reflex modulation during fictive “swimming” in Xenopus laevis embryos has been examined with intracellular recordings from rhythmically active spinal neurons. (1) At rest, cutaneous trunk or tail skin stimulation evokes EPSPs in motoneurons and premotor excitatory and inhibitory interneurons of the opposite motor system. During swimming, these EPSPs can only be evoked during the depolarized phase of activity and can then produce extra action potentials that lead to phase-dependent reflexes in ventral roots. On the stimulated side, IPSPs are evoked in rhythmic neurons that can block centrally generated action potentials if the stimulus coincides with the inhibited phase of the swimming cycle. This inhibition suppresses ventral root discharge in a phase-dependent manner. (2) The presence of premotor interneurons in the crossed reflex pathway suggests two parallel routes for cutaneous excitation to reach the motoneurons, one direct and the other indirect through excitatory premotor interneurons. During swimming, the crossed excitation through both routes is gated by the rhythm-generating circuit to allow summation in motoneurons only during the depolarized phase of the swim cycle. (3) Following phase- dependent reflexes, the frequency of swimming is raised for several cycles, a phenomenon that requires sensory activation of premotor rhythm-generating interneurons. The results provide evidence on the role of identified premotor spinal interneurons in phase-dependent reflex modulation.
Attribution of global surface warming without dynamical models

Detection and attribution studies of observed surface temperature changes have served to consolidate our understanding of the climate system and its past and future behaviour. Most recent studies analysing up‐to‐date observations have relied on general circulation models (GCMs) to provide estimates of the responses to various external forcings. Here we revisit a methodology which instead estimates the responses using a simple model tuned directly to the observed record, paralleling a technique currently used with GCM output. The effects of greenhouse gases, tropospheric sulphate aerosols, and volcanic aerosols are all detected in the observed record, while the effects of solar irradiance are unclear. These results provide further observational constraints on past and future warming estimates consistent with those from recent studies with GCMs, supporting the notion that current estimates are robust against the modelling system used.
Causal links between external contingencies of self-worth and mindfulness

Outcome research confirming the salutary effects of mindfulness-based interventions has proliferated in the last fifteen years. In contrast, there has been very little research into intra-individual factors that may enhance or inhibit mindfulness. The present study examined a proposal by Brown, Ryan and Creswell (2007a) that external contingent self-worth may act as an inhibiting factor of mindfulness. Undergraduate participants performed two reading tasks, one under neutral conditions and one under the influence of an academic ego-threat. Momentary mindfulness levels were measured retrospectively following both reading tasks. It was expected that levels of academic competence contingent self-worth would predict changes in momentary mindfulness levels between the ego-threat and neutral condition, and in addition, that worry would mediate the relationship. The study findings supported both hypotheses. The theoretical implications of the study are discussed in relation to the salience of self-investment in present moment events as a controlling variable of levels of momentary mindfulness.
Effects of bortezomib on human neuroblastoma cells in vitro and in a metastatic xenograft model.

BACKGROUND Inhibition of the proteasome-ubiquitin pathway has shown to exert growth inhibitory effects on several human carcinoma cell lines. In this study, the influence of bortezomib on human neuroblastoma cells was investigated. MATERIALS AND METHODS Cell proliferation of seven human neuroblastoma cell lines under bortezomib treatment was assessed by a colorimetric XTT-based assay. Subsequently, the influence of bortezomib on SK-N-SH neuroblastoma cell growth was examined in a spontaneous metastatic SCID mouse model. RESULTS In vitro, bortezomib inhibited proliferation of all cell lines in a dose-dependent manner. In the xenograft model, bortezomib treatment did not have an effect on the tumour weight, but induced apoptosis and reduced mitosis and angiogenesis, as well as the formation of pulmonary metastases. CONCLUSION Bortezomib has anticancer effects on neuroblastoma cells in vitro and in a metastatic xenograft model. These findings provide a basis for further investigations of bortezomib in the treatment of metastasising neuroblastoma.
Trends in Occupational Origins of Physicians

structure," which paper will report in some detail the responses to the open-ended series of questions. This study suggests the necessity of a more critical analysis of the conceptual definitions of class consciousness and class identifications and the research operations by which they are tapped. It also emphasizes that class identification findings are a resultant of the particular questionwording technique employed. It is suggested that the open-ended question approach may be more appropriate in research dealing with class consciousness and class identification than predetermined class categories techniques.
Surgical Management of Congenital Abdominal Wall Defects in Germany: A Population-Based Study and Comparison with Literature Reports

Abstract Introduction We aimed to analyze for the first time the characteristics, treatment modalities, and outcomes in infants with congenital abdominal wall defects (CAWDs) in Germany and to compare the results with current literature reports. Patients and Methods Data of a health insurance covering approximately 10% of the German population were analyzed. Patients who had undergone CAWD closure during a period of nearly 6 years were included. Surgical approach was categorized into primary versus secondary closure. Complications were defined as any reintervention within 1 year after initial treatment. Results Patients with gastroschisis were treated in 24 centers, newborns with omphalocele in 34 centers. There was no mortality, and the type of surgical approach had no significant impact on the incidence of complications in both gastroschisis and omphalocele. Out of 39 patients with gastroschisis, 72% had undergone primary closure being associated with a shorter duration of ventilation (p = 0.003) and hospitalization (p < 0.001). Out of 54 patients with omphalocele, 54% had undergone secondary closure, whereas modality of management did not affect duration of ventilation and hospitalization. Although heterogeneous, data of the current literature were comparable to those of this study. Conclusion Unbiased data demonstrate for the first time that the quality of the current surgical management of newborns with CAWD across Germany is excellent. There was no correlation of complications with the method of closure in gastroschisis and omphalocele.
The Psychosocial Implications of Managing Work and Family Caregiving Roles: Gender Differences Among Information Technology Professionals

An increasing number of adults, both men and women, are simultaneously managing work and family caregiving roles. Guided by the stress process model, we investigate whether 823 employees occupying diverse family caregiving roles (child caregiving only, elder caregiving only, and both child caregiving and elder caregiving, or “sandwiched” caregiving) and their noncaregiving counterparts in the information technology division of a white-collar organization differ on several indicators of psychosocial stress along with gender differences in stress exposure. Compared with noncaregivers, child caregivers reported more perceived stress and partner strain whereas elder caregivers reported greater perceived stress and psychological distress. With the exception of work-to-family conflict, sandwiched caregivers reported poorer overall psychosocial functioning. Additionally, sandwiched women reported more family-to-work conflict and less partner support than their male counterparts. Further research on the implications of combining a white-collar employment role with different family caregiving roles is warranted.
Policing in Cool and Hot Climates: Legitimacy, Power and the Rise and Fall of Mass Stop and Search in Scotland

Prior to the amalgamation of Scotland’s eight police forces into Police Scotland in 2013 by the Scottish National Party government, Scottish policing generally enjoyed a ‘cool’ political climate, with low scrutiny and minimal political engagement. This paper argues these conditions hindered the critical interrogation of Scottish policing, allowing a policy of unregulated and unfettered stop and search to flourish unchallenged for two decades. We then show how this policy was swiftly dismantled in the ‘heated’ environment that followed centralization, a move that gave rise to the unprecedented scrutiny of Scottish policing by media and political commentators. The analysis suggests that the legitimacy and reputation of the police may owe a debt to political environments that encourage either ‘soft’ or ‘hard’ analysis. Also, that more heated political environments, often disparaged by academics and criminal justice practitioners, can drive accountability and contribute to more progressive outcomes.
A space-time correlation model for multielement antenna systems in mobile fading channels

Analysis and design of multielement antenna systems in mobile fading channels require a model for the space-time cross correlation among the links of the underlying multiple-input multiple-output (MIMO) channel. In this paper, we propose a general space-time cross-correlation function for mobile frequency nonselective Rice fading MIMO channels, in which various parameters of interest such as the angle spreads at the base station and the user, the distance between the base station and the user, mean directions of the signal arrivals, array configurations, and Doppler spread are all taken into account. The new space-time cross-correlation function includes all the relevant parameters of the MIMO fading channel in a clean compact form, suitable for both mathematical analysis and numerical calculations/simulations. It also covers many known correlation models as special cases. We demonstrate the utility of the new space-time correlation model by clarifying the limitations of a widely accepted correlation model for MIMO fading channels. As another application, we quantify the impact of nonisotropic scattering around the user, on the capacity of a MIMO fading channel.
Gender Diversity in Top Management and Firm Performance : An Analysis with the IAB-Establishment Panel

In recent years the political and empirical debate about female participation in top management has intensified. The questions as to how women contribute to a company’s success and whether employing women in top management positions pays off on the bottom line remain to be conclusively answered, as the existing empirical evidence is ambiguous. Therefore, I propose a framework to help clarify the potential mediating and moderating effects of gender diversity and firm performance. Thus far, few papers have analyzed the gender diversity-performance relationship for Germany. This study therefore aims to explore the effects of gender diversity in top management on firm performance in Germany using unique data from the Institute for Employment Research’s Establishment Panel Survey. Various production functions reveal a slight, yet significant negative relationship between the proportion of women in top management positions in 2008 and establishment performance. An instrument variable approach is estimated to account for endogeneity, providing evidence for the robustness of the negative link. Further estimations highlight the importance of the moderating influences of the characteristics of the establishment, the industry and the environment, which shape the relationship between the share of women in top management positions and establishment performance. JEL Classification: J16, L25
Transient improvement induced by motor fatigue in focal occupational dystonia: The handgrip test

Muscle fatigue induced by a previous sustained contraction temporarily decreases the motor output, transiently worsening motor performance. Whether muscle fatigue alters motor performance also in dystonia—a disorder whose main pathophysiological abnormality is motor overflow—remains unknown. To assess the effects of muscle fatigue in patients with focal occupational upper limb dystonia, we studied the effect of a previous maximum fatiguing voluntary contraction on motor performance in 10 musicians with focal occupational dystonia, in 3 musicians with hand motor impairment due to non‐dystonic disorders, and in 5 normal musicians. The fatiguing task consisted of grasping a spring handgrip as long as possible until the task failed. In dystonic musicians, a fatiguing contraction significantly improved motor performance. The improvement lasted less than 5 minutes and appeared only after fatigue of the affected upper limb. In contrast, in musicians with non‐dystonic motor impairment, motor performance remained unchanged or worsened, and normal musician performance consistently worsened. © 2001 Movement Disorder Society.