Miracle-dz/UniFAR-FTUs huggingface dataset:
The Runaway Growth of Intermediate-Mass Black Holes in Dense Star Clusters

We study the growth rate of stars via stellar collisions in dense star clusters, calibrating our analytic calculations with direct N-body simulations of up to 65,536 stars, performed on the GRAPE family of special-purpose computers. We find that star clusters with initial half-mass relaxation times ≲25 Myr are dominated by stellar collisions, the first collisions occurring at or near the point of core collapse, which is driven by the segregation of the most massive stars to the cluster center, where they end up in hard binaries. The majority of collisions occur with the same star, resulting in the runaway growth of a supermassive object. This object can grow up to ~0.1% of the mass of the entire star cluster and could manifest itself as an intermediate-mass black hole (IMBH). The phase of runaway growth lasts until mass loss by stellar evolution arrests core collapse. Star clusters older than about 5 Myr and with present-day half-mass relaxation times ≲100 Myr are expected to contain an IMBH.
Probiotic Yogurt Culture Bifidobacterium Animalis Subsp. Lactis BB-12 and Lactobacillus Acidophilus LA-5 Modulate the Cytokine Secretion by Peripheral Blood Mononuclear Cells from Patients with Ulcerative Colitis

Abstract Background: There are some evidences for the immunomodulation disorders in the response to intestinal microbiota in inflammatory bowel disease. Yogurt is a fermented milk product made with a starter culture consisting of different probiotics which could be colonized in intestine. However, the role of probiotics in the aetiopathogenesis of ulcerative colitis (UC) has not been clarified. To determine how the immune system responds to these bacteria this study was planned. Methods: Bifidobacterium lactis BB-12 (B. lactis) and Lactobacillus acidophilus LA-5 (L. acidophilus) were cultivated on MRS broth. PBMCs of 36 UC patients were separated by Ficoll-Hypaque centrifugation and co-cultured with different concentrations of UV killed bacteria in RPMI-1 640 plus 10% FCS for 48/72 h. IL-10, TGF-β, IFN-γ and TNF-α were measured in supernatant of PBMCs by ELISA. Results: Both bacteria significantly augmented IL-10, TGF-β, IFN-γ and TNF-α compared to control (p<0.001). The secretion levels of IL-10 and TGF-β by B. lactis- compared to L. acidophilus-stimulated PBMCs were significantly higher (p<0.05, p<0.01 respectively). The secretion levels of TNF-α and IFN-γ by PBMCs after 72 h were significantly lower compared to 48 h stimulation by B. lactis (p<0.001, p<0.035 respectively). Conclusion: These data show that both probiotics may trigger the pro- and anti-inflammatory immune response of UC patients. It seems that IL-10/TGF-β uprising by B. lactis could be the reason of TNF-α/IFN-γ reduction. Therefore albeit B. lactis still stimulates the effector Th cells but because of more stimulatory effect on Tregs, it could be a good potential therapeutic candidate for further investigation.
An investigation of temporal modeling in blind signal separation

This paper investigates the performance of blind signal separation (BSS) algorithms that exploit the temporal predictability of speech. Specifically, the investigation considers how the separation performance of two BSS algorithms will be affected when the length of the AR process (used in the algorithms to model speech) is varied. The investigation concludes that the length of the AR process (prediction order) has a significant impact on separation performance. In particular, the separation performance of both algorithms is degraded, if the AR model’s prediction order, over fits, or under fits, the temporal structure of the speech. It is revealed that a prediction order of 3050 provides maximum separation performance for natural speech, however a prediction order of 10 is more applicable if computational cost is a consideration.
Parental embodied mentalizing: how the nonverbal dance between parents and infants predicts children’s socio-emotional functioning

ABSTRACT Parental mentalizing – the parent’s ability to envision the child’s mental states (such as desires, thoughts, or wishes) – has been argued to underlie a parent’s ability to respond sensitively to their child’s emotional needs, and thereby promote advantageous cognitive and socio-emotional development. Mentalizing is typically operationalized in terms of how parents talk to or about their infants. This work extends research on mentalizing by operationalizing parental mentalizing exclusively in terms of nonverbal, bodily based, interactive behavior, namely parental embodied mentalizing(PEM). The purpose of the current research was twofold: (1) to establish the reliability and validity of the PEM coding system; and (2) to evaluate whether such measurement predicts infant and child cognitive and socio-emotional functioning. Assessing 200 mother–infant dyads at 6 months using the coding of PEM proved both reliable and valid, including predicting child attachment security at 15 and 36 months, and language abilities, academic skills, behavior problems, and social competence at 54 months, in many cases even after taking into consideration traditional measures of parenting, namely maternal sensitivity. Conceptual, empirical, and clinical implications are discussed.
Evolution of the extensively drug-resistant F15/LAM4/KZN strain of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa.

BACKGROUND Although several hot spots of multidrug-resistant tuberculosis have been identified on the African continent, extensive drug resistance (XDR) has not been reported until recently, when a large number of XDR cases were identified in KwaZulu-Natal. The majority of the patients involved were infected with the same strain of Mycobacterium tuberculosis (F15/LAM4/KZN). We report this strain's development from multidrug resistance to XDR. METHODS We searched databases for studies performed during the period 1994-2005 that involved the resistance patterns of isolates of M. tuberculosis with the F15/LAM4/KZN strain fingerprint. RESULTS As early as 1994, the F15/LAM4/KZN strain was responsible for a number of cases of multidrug-resistant tuberculosis, indicating the ability of the strain to cause cases of primary resistant tuberculosis. Some of the isolates were also resistant to streptomycin. From 1994 onwards, multidrug-resistant isolates with resistance to additional drugs were found, and the first XDR isolate was discovered in 2001. CONCLUSIONS Drug resistance to as many as 7 drugs developed in a local strain of M. tuberculosis in slightly more than a decade. This coincided with the introduction of the directly observed therapy-based and directly observed therapy-plus-based tuberculosis-control programs. It is postulated that the introduction of these programs in the absence of susceptibility testing or drug resistance surveillance has been instrumental in the development of XDR in this highly transmissible F15/LAM4/KZN strain. The expanding pool of human immunodeficiency virus-infected, tuberculosis-susceptible individuals has likely contributed to this development.
Models for the subjective effects of loss, noise, and talker echo on telephone connections

Tests have been conducted at Bell Laboratories within the last 10 years to obtain subjective evaluations of the effects of loss, noise, and talker echo on telephone transmission quality. We use these subjective test results to formulate graphical and analytical models of subjective opinion that can be used in network planning studies to evaluate transmission performance of the network and to study the effects of network changes on performance. These models are based on the concept of a generalized transmission-rating scale. Separate opinion curves for each test take into account differences caused by factors such as subject group, type of test, and range of conditions. We also describe the methods of data analysis used in the formulation of the transmission-rating scale and opinion models, provide a comparison of the test results with the models, and discuss the models in sufficient detail to permit their application in transmission planning studies.
Magnetic resonance spectroscopy reveals abnormalities of glucose metabolism in the Alzheimer's brain

Brain glucose hypometabolism is a prominent feature of Alzheimer's disease (AD), and in this case–control study we used Magnetic Resonance Spectroscopy (MRS) to assess AD‐related differences in the posterior cingulate/precuneal ratio of glucose, lactate, and other metabolites.
Combining Crypto with Biometrics Effectively

We propose the first practical and secure way to integrate the iris biometric into cryptographic applications. A repeatable binary string, which we call a biometric key, is generated reliably from genuine iris codes. A well-known difficulty has been how to cope with the 10 to 20 percent of error bits within an iris code and derive an error-free key. To solve this problem, we carefully studied the error patterns within iris codes and devised a two-layer error correction technique that combines Hadamard and Reed-Solomon codes. The key is generated from a subject's iris image with the aid of auxiliary error-correction data, which do not reveal the key and can be saved in a tamper-resistant token, such as a smart card. The reproduction of the key depends on two factors: the iris biometric and the token. The attacker has to procure both of them to compromise the key. We evaluated our technique using iris samples from 70 different eyes, with 10 samples from each eye. We found that an error-free key can be reproduced reliably from genuine iris codes with a 99.5 percent success rate. We can generate up to 140 bits of biometric key, more than enough for 128-bit AES. The extraction of a repeatable binary string from biometrics opens new possible applications, where a strong binding is required between a person and cryptographic operations. For example, it is possible to identify individuals without maintaining a central database of biometric templates, to which privacy objections-might be raised
Understanding the factors regulating host–microbiome interactions using Caenorhabditis elegans

The Human Microbiome Project was a research programme that successfully identified associations between microbial species and healthy or diseased individuals. However, a major challenge identified was the absence of model systems for studying host–microbiome interactions, which would increase our capacity to uncover molecular interactions, understand organ-specificity and discover new microbiome-altering health interventions. Caenorhabditis elegans has been a pioneering model organism for over 70 years but was largely studied in the absence of a microbiome. Recently, ecological sampling of wild nematodes has uncovered a large amount of natural genetic diversity as well as a slew of associated microbiota. The field has now explored the interactions of C. elegans with its associated gut microbiome, a defined and non-random microbial community, highlighting its suitability for dissecting host–microbiome interactions. This core microbiome is being used to study the impact of host genetics, age and stressors on microbiome composition. Furthermore, single microbiome species are being used to dissect molecular interactions between microbes and the animal gut. Being amenable to health altering genetic and non-genetic interventions, C. elegans has emerged as a promising system to generate and test new hypotheses regarding host–microbiome interactions, with the potential to uncover novel paradigms relevant to other systems. This article is part of the theme issue ‘Sculpting the microbiome: how host factors determine and respond to microbial colonization’.
Diabetes with Hypertension as Risk Factors for Adult Dengue Hemorrhagic Fever in a Predominantly Dengue Serotype 2 Epidemic: A Case Control Study

Background Dengue hemorrhagic fever (DHF) is a severe form of dengue, characterized by bleeding and plasma leakage. A number of DHF risk factors had been suggested. However, these risk factors may not be generalized to all populations and epidemics for screening and clinical management of patients at risk of developing DHF. This study explored demographic and comorbidity risk factors for DHF in adult dengue epidemics in Singapore in year 2006 (predominantly serotype 1) and in year 2007–2008 (predominantly serotype 2). Methods A retrospective case-control study was conducted with 149 DHF and 326 dengue fever (DF) patients from year 2006, and 669 DHF and 1,141 DF patients from year 2007–2008. Demographic and reported comorbidity data were collected from patients previously. We performed multivariate logistic regression to assess the association between DHF and demographic and co-morbidities for year 2006 and year 2007–2008, respectively. Results Only Chinese (adjusted odds ratio [AOR] = 1.90; 95% confidence interval [CI]: 1.01–3.56) was independently associated with DHF in year 2006. In contrast, age groups of 30–39 years (AOR = 1.41; 95% CI:1.09–1.81), 40–49 years (AOR = 1.34; 95% CI:1.09–1.81), female (AOR = 1.57; 95% CI:1.28–1.94), Chinese (AOR = 1.67; 95% CI:1.24–2.24), diabetes (AOR = 1.78; 95% CI:1.06–2.97), and diabetes with hypertension (AOR = 2.16; 95%CI:1.18–3.96) were independently associated with DHF in year 2007–2008. Hypertension was proposed to have effect modification on the risk of DHF outcome in dengue patients with diabetes. Chinese who had diabetes with hypertension had 2.1 (95% CI:1.07–4.12) times higher risk of DHF compared with Chinese who had no diabetes and no hypertension. Conclusions Adult dengue patients in Singapore who were 30–49 years, Chinese, female, had diabetes or diabetes with hypertension were at greater risk of developing DHF during epidemic of predominantly serotype 2. These risk factors can be used to guide triaging of patients who require closer clinical monitoring and early hospitalization in Singapore, when confirmed in more studies.
THE PRACTICE OF ECT IN INDIA: II. THE PRACTICAL ADMINISTRATION OF ECT

SUMMARY A questionnaire on ECT, tapping attitudes, opinions and usage, was mailed to all medical members of the Indian Psychiatric Society whose addresses were known; 263 (28.8%) responded. This paper, the second in a series that presents the results of the survey, describes the practical administration of ECT. Specific issues discussed are the availability of a cardiopulmonary resuscitation kit, ECT premedication, the ECT device, certain aspects of ECT stimulation, the electrode placement during ECT, administration of multiple ECT during a single treatment session and monitoring of the seizure duration. It is concluded that, in many respects, the practical administration of ECT in India in suboptimal; further research is required in certain areas.
Radical-pair model of magnetoreception with spin–orbit coupling

The mechanism used by migratory birds to orientate themselves using the geomagnetic field is still a mystery in many species. The radical pair mechanism, in which very weak magnetic fields can influence certain types of spin-dependent chemical reactions, leading to biologically observable signals, has recently imposed itself as one of the most promising candidates for certain species. This is thanks both to its extreme sensitivity and its capacity to reproduce results from behavioral studies. Still, in order to gain a directional sensitivity, an anisotropic mechanism is needed. Recent proposals have explored the possibility that such an anisotropy is due to the electron–nucleus hyperfine interaction. In this work we explore a different possibility, in which the anisotropy is due to spin–orbit coupling between the electron spin and its angular momentum. We will show how a spin–orbit coupling-based magnetic compass can have performances comparable with the usually studied nuclear hyperfine based mechanism. Our results could thus help researchers actively looking for candidate biological molecules which may host magnetoreceptive functions, both to describe magnetoreception in birds as well as to develop artificial chemical compass systems.
Fluticasone propionate spray and betamethasone sodium phosphate mouthrinse: a randomized crossover study for the treatment of symptomatic oral lichen planus.

BACKGROUND Symptomatic oral lichen planus (OLP) has been palliated with a wide spectrum of topical and systemic therapies. Although the majority of management strategies include corticosteroids, few have been evaluated in randomized controlled trials. OBJECTIVE We investigated the acceptability and efficacy of topical fluticasone propionate spray (FP) and betamethasone sodium phosphate mouthrinse (BSP) upon the signs and symptoms of OLP, assessing patient quality of life changes as a consequence of these therapies. METHODS We implemented a randomized, crossover study in which each drug was administered for a period of 6 weeks with an intervening washout period of 2 weeks at an outpatient oral medicine unit in London, United Kingdom. We treated 48 patients with biopsy-proven symptomatic OLP, and 44 patients (92%) completed the study. The dosage was 50 microg two dose unit sprays and BSP 500 microg, each 4 times daily. Symptomatic improvement was evaluated by means of a visual analogue scale (VAS), the McGill pain score, the Oral Health Impact Profile (OHIP), and Oral Health Quality of Life (OHQoL) questionnaires. The total surface area of the lesions, including all white, erythematous, and ulcerative lesions was measured at each visit. The efficacy, ease of application, and adverse effects associated with each medication were recorded. RESULTS Both FP and BSP mouthwash caused both a statistically significant reduction in painful symptoms as measured by the VAS and improvement in quality of life as measured by the OHIP and OHoQL indices. There was no significant difference between the two corticosteroids in their efficacy in reducing painful symptoms (measured by the VAS) or in their effect on patient quality of life. Both FP and BSP significantly reduced the surface area of oral lesions. However, FP was statistically significantly better than BSP in reducing lesion surface area. There was no statistically significant difference between the patient-assessed effects of the 2 therapies. CONCLUSIONS FP and BSP are both effective in the short-term clinical management of symptomatic OLP. FP is more acceptable to patients than BSP because of the convenience of the spray form.
AAEE minimonograph #28: Injury to peripheral motor nerves

Nerve injury triggers a sequence of electrophysiological events dependent upon changes occurring both at the neuromuscular junction and the muscle membrane. The time course of these physiologic and morphologic alterations is reviewed in light of recent information provided by studies of extrajunctional acetylcholine receptors, axoplasmic transport, and freeze‐fracture electron microscopy. A thorough knowledge of these changes is essential to understanding the clinical impact of nerve injury.
Preliminary Evaluation of a Light-Based Contact Hearing Device for the Hearing Impaired

Objective To assess the safety, stability, and performance of the broad-spectrum, light-based contact hearing device (CHD) on listeners with hearing impairment. Study Design Feasibility study. Setting Single-site research and development facility. Participants Thirteen participants with symmetric mild-to-severe sensorineural hearing impairment had the CHD placed bilaterally. Intervention A custom-molded light-activated tympanic contact actuator (TCA) was placed into each ear by a physician, where it stayed in contact with the umbo and a portion of the medial wall of the ear canal for 4 months. Each CHD was calibrated and programmed to provide appropriate broad-spectrum amplification. Main Outcome Measures Safety was determined through routine otologic examinations. Aided and pre-TCA-insertion unaided audiometric thresholds (functional gain), maximum gain before feedback, tympanic membrane damping, Reception Threshold for Sentences (RTS), and Abbreviated Profile of Hearing Aid Benefit (APHAB) measurements were made to characterize system performance as well as the benefits of amplification via the CHD. Results The TCAs remained on participants’ ears for an average total of 122 days, without causing signs of inflammation or infection, and there were no serious device-related adverse events. Measured average maximum output of 90 to 110 dB SPL in the range of 0.25 to 10 kHz, average maximum gain before feedback of 40 dB, and functional gain through 10 kHz show extended-bandwidth broad-spectrum output and gain. RTS results showed significant aided improvements of up to 2.8 dB, and APHAB results showed clinically significant aided benefits in 92% of participants (11/12). Conclusion The safety, stability, and performance demonstrated in this initial 4-month study suggest that the CHD may offer a feasible way of providing broad-spectrum amplification appropriate to treat listeners with mild-to-severe hearing impairment.
The Effects of Media Reports on Disease Spread and Important Public Health Measurements

Controlling the spread of influenza to reduce the effects of infection on a population is an important mandate of public health. Mass media reports on an epidemic or pandemic can provide important information to the public, and in turn, can induce positive healthy behaviour practices (i.e., handwashing, social distancing) in the individuals, that will reduce the probability of contracting the disease. Mass media fatigue, however, can dampen these effects. Mathematical models can be used to study the effects of mass media reports on epidemic/pandemic outcomes. In this study we employ a stochastic agent based model to provide a quantification of mass media reports on the variability in important public health measurements. We also include mass media report data compiled by the Global Public Health Intelligence Network, to study the effects of mass media reports in the 2009 H1N1 pandemic. We find that the report rate and the rate at which individuals relax their healthy behaviours (media fatigue) greatly affect the variability in important public health measurements. When the mass media reporting data is included in the model, two peaks of infection result.