Miracle-dz/UniFAR-FTUs huggingface dataset:
A study of the career orientations of information systems students and professionals

This research study investigates the career orientations of IS students and professionals to determine if differences exist. A sample of IS professionals from twelve organizations and students from two universities were administered the Career Orientations Inventory. A principal components analysis determined the structure of the instrument for the sample and was used to determine the career anchors exhibited by the two groups, Statistical t-tests were used to examine the career orientation differences between IS students and professionals. Results showed statistical differences (p < .05) between the two groups for the autonomy, identity, managerial competence, service, technical competence, and variety anchors. Implications of these results for IS practice and education are explored.
Applying Cobit 4.1 to knowledge governance: Matrix ProGOB to control governance objectives

Knowledge governance analyses to what extent knowledge processes are influenced by governance mechanisms. A number of advances have been made in this field, but much space remains for research. However, before advancing in this direction, we must have a tool to direct efforts and provide a certain notion of the progress made in research. This paper proposes a matrix that brings knowledge management processes into relation with knowledge governance objectives (ProGOb matrix). This matrix provides information about which knowledge processes affect which governance objectives, and to what extent. The ProGOb matrix can be highly useful in the current tendency towards the Web 2.0, where knowledge distribution requires knowledge governance which has clear objectives and takes specific actions.
EKV mutant connexin 31 associated cell death is mediated by ER stress

The epidermis expresses a number of connexin (Cx) proteins that are implicated in gap junction-mediated cell communication. Distinct dominantly inherited mutations in Cx31 cause the skin disease erythrokeratoderma variabilis (EKV) and hearing loss with or without neuropathy. Functional studies reveal tissue-specific effects of these Cx31 disease-associated mutations. The Cx31 mutants (R42P)Cx31, (C86S)Cx31 and (G12D)Cx31 are associated with EKV and the mutant (66delD)Cx31 with peripheral neuropathy and hearing loss, however the mechanisms of pathogenesis remain to be elucidated. Expression of (R42P)Cx31, (C86S)Cx31 and (G12D)Cx31 in vitro, but not (WT)Cx31 or (66delD)Cx31, cause elevated levels of cell-type specific cell death. Previous studies suggest that Cx-associated cell death may be related to abnormal ‘leaky’ hemichannels but we produced direct evidence against that being the major mechanism. Additionally, our immunocytochemistry showed upregulation of components of the unfolded protein response (UPR) in cells expressing the EKV-associated Cx31 mutants but not (WT)Cx31 or (66delD)Cx31. We conclude that the endoplasmic reticulum (ER) stress leading to the UPR is the main mechanism of mutant Cx31-associated cell death. These results indicate that, in vivo, ER stress may lead to abnormal keratinocyte differentiation and hyperproliferation in EKV patient skin.
Modulated QMF filter banks with perfect reconstruction

Necessary and sufficient conditions for perfect reconstruction (PR) in a modulated filter bank are derived. It is shown that, for a bank of M filters of length L, PR can be obtained when L = 2KM, for any positive integer K, whereas previous results guaranteed PR only for K = 1.
Fast Fault-Tolerant Time Synchronization for Wireless Sensor Networks

A wireless sensor network (WSN) typically consists of a large number of small-sized devices that have very low computational capability, small amounts of memory and the need to conserve energy as much as possible (most commonly by entering suspended mode for extended periods of time). Previous approaches for WSN time synchronization do not satisfactorily address all of the requirements of WSN environments. Thus, this paper proposes a new fault-tolerant WSN time sychronization algorithm that is extremely fast (when compared to previous algorithms), achieves a guaranteed level of time synchronization for all non-faulty nodes, can accommodate nodes that enter suspended mode and then wake up, utilizes very little communication and computation resources (thereby leaving those resources available for use by other applications), operates in a completely decentralized manner and tolerates up to f faulty nodes. The efficacy of the proposed algorithm is shown using analysis and experimental results.
A transactional perspective on occupation: a critical reflection

AbstractBackground: The emergence of a transactional perspective on occupation, informed primarily by John Dewey’s work, has gained increasing popularity in occupational science and occupational therapy.Aim: The aim of this paper is to offer a critical reflection on a transactional perspective on occupation and to advance the dialogue on a transactional perspective on occupation.Methods: A framework for critical reflection of theory was applied to a transactional perspective on occupation, exploring five domains of theory usefulness: clarity, simplicity, generality, accessibility, and importance.Findings: A transactional perspective on occupation presents with clear strengths including its ability to capture complex relationships, its generality, and its importance to occupational research. However, there is a need to address issues in clarity and accessibility by establishing consistent definitions of constructs, further developing the construct of occupation within the perspective, and applying methods .
Terms of use : Click here Safe zero-cost coercions for Haskell

Generative type abstractions – present in Haskell, OCaml, and other languages – are useful concepts to help prevent programmer errors. They serve to create new types that are distinct at compile time but share a run-time representation with some base type. We present a new mechanism that allows for zero-cost conversions between generative type abstractions and their representations, even when such types are deeply nested. We prove type safety in the presence of these conversions and have implemented our work in GHC.
Modelling of Compressive Strength of Cement Slurry at different Slurry Weights and Temperatures

The effect of temperature and slurry weight on compressive strength was investigated. Tests were conducted for 70, 80, 90,100 and 105 °F as well as slurry weights of 1.96, 1.98 and 2.0kg/l for test periods of 12, 24, 72 and 168hrs respectively. Test results indicated that compressive strength is a function of temperature and slurry weight, at a higher temperature and slurry weight respectively, compressive strength development is faster and vice-versa. Model coefficients were obtained using DATA FIT Engineering software and models which predict compressive strength with respect to temperature and slurry weight were developed. Results calculated from the model equation showed a good agreement with experimental values with less than 1% deviation. This will help predict compressive strength at different temperatures and slurry weights thereby saving time and rigour associated with actual laboratory pilot tests.
SemEval-2016 Task 10: Detecting Minimal Semantic Units and their Meanings (DiMSUM)

This task combines the labeling of multiword expressions and supersenses (coarse-grained classes) in an explicit, yet broad-coverage paradigm for lexical semantics. Nine systems participated; the best scored 57.7% F 1 in a multi-domain evaluation setting, indicating that the task remains largely unresolved. An error analysis reveals that a large number of instances in the data set are either hard cases, which no systems get right, or easy cases, which all systems correctly solve.
Flux Transport Solar Dynamos with Near-Surface Radial Shear

Corbard & Thompson analyzed quantitatively the strong radial differential rotation that exists in a thin layer near the solar surface. We investigate the role of this radial shear in driving a flux transport dynamo operating with such a rotation profile. We show that despite being strong, near-surface radial shear effectively contributes only ~1 kG (~30% of the total) to the toroidal fields produced there unless an abnormally high, surface α-effect is included. While 3 kG spot formation from ~1-2 kG toroidal fields by convective collapse cannot be ruled out, the evolutionary pattern of these model fields indicates that the polarities of spots formed from the near-surface toroidal field would violate the observed polarity relationship with polar fields. This supports previous results that large-scale solar dynamos generate intense toroidal fields in the tachocline, from which buoyant magnetic loops rise to the photosphere to produce spots. Polar fields generated in flux transport models are commonly much higher than observed. We show here that by adding enhanced diffusion in the supergranulation layer (originally proposed by Leighton), near-surface toroidal fields undergo large diffusive decay preventing spot formation from them, as well as reducing polar fields closer to the observed values. However, the weaker polar fields lead to the regeneration of a toroidal field of less than ~10 kG at the convection zone base, too weak to produce spots that emerge in low latitudes, unless an additional poloidal field is produced at the tachocline. This is achieved by a tachocline α-effect, previously shown to be necessary for coupling the north and south hemispheres to ensure toroidal and poloidal fields that are antisymmetric about the equator.
Competition and Growth in Neo-Schumpeterian Models

We study the effect of product market competition on the incentives to innovate and the economy’s rate of growth in an endogenous growth model. We extend previous works in industrial organization by assuming that innovation is sequential and cumulative, and early endogenous growth models by accounting for the possibility that in each period many asymmetric firms (i.e., an endogenously determined number of successive innovators) are simultaneously active. We identify the price effect, the front loading of profits, and the productive efficiency effect associated with an increase in competitive pressure. The price effect reduces the incentives to innovate, but both the front loading of profits and the productive efficiency effect raise the incentives to innovate. We demonstrate circumstances in which the productive efficiency effect dominates the price effect. In these circumstances, the front loading of profits and the fact that the productive efficiency effect dominates the price effect compound to make the equilibrium rate of growth increase with the intensity of competition.
Tensor Versus Matrix Completion: A Comparison With Application to Spectral Data

Tensor completion recently emerged as a generalization of matrix completion for higher order arrays. This problem formulation allows one to exploit the structure of data that intrinsically have multiple dimensions. In this work, we recall a convex formulation for minimum (multilinear) ranks completion of arrays of arbitrary order. Successively we focus on completion of partially observed spectral images; the latter can be naturally represented as third order tensors and typically exhibit intraband correlations. We compare different convex formulations and assess them through case studies.
Evolution of nakedness in Homo sapiens

Homo sapiens L. is the only existing primate species lacking in functionally effective thermally insulating fur. As all other primates have considerable hair covering, it has always been accepted that our ancestors must once have had a respectable amount of body hair. Unfortunately, fossils cannot help us when it comes to differences in skin and hair. Recent DNA analysis, however, has given us some idea of when and where the great denudation took place. A number of hypotheses have been proposed to account for this feature, but none of these has gained general acceptance. In this paper, I present these hypotheses in the light of current empirical evidence and discussion.
Ectodomain Shedding of the Amyloid Precursor Protein: Cellular Control Mechanisms and Novel Modifiers

Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer’s disease amyloid-β (Aβ) peptide and occurs through two different protease activities termed α- and β-secretase. Both proteases compete for APP cleavage, but have opposite effects on Aβ generation. At present, little is known about the cellular pathways that control APP α- or β-secretase cleavage and thus Aβ generation. To explore the contributory pathways in more detail we have recently employed an expression cloning screen and identified several activators of APP cleavage by α- or β-secretase. Among them were known activators of APP cleavage, for example protein kinase A, and novel activators, such as endophilin and the APP homolog amyloid precursor-like protein 1 (APLP1). Mechanistic analysis revealed that both endophilin and APLP1 reduce the rate of APP endocytosis and strongly increase APP cleavage by α-secretase. This review summarizes the results of the expression cloning screen in the context of recent developments in our understanding of the cellular regulation of APP α-secretase cleavage. Moreover, it highlights the particular importance of endocytic APP trafficking as a prime modulator of APP shedding.
Neuroimaging of direction-selective mechanisms for second-order motion.

Psychophysical findings have revealed a functional segregation of processing for 1st-order motion (movement of luminance modulation) and 2nd-order motion (e.g., movement of contrast modulation). However neural correlates of this psychophysical distinction remain controversial. To test for a corresponding anatomical segregation, we conducted a new functional magnetic resonance imaging (fMRI) study to localize direction-selective cortical mechanisms for 1st- and 2nd-order motion stimuli, by measuring direction-contingent response changes induced by motion adaptation, with deliberate control of attention. The 2nd-order motion stimulus generated direction-selective adaptation in a wide range of visual cortical areas, including areas V1, V2, V3, VP, V3A, V4v, and MT+. Moreover, the pattern of activity was similar to that obtained with 1st-order motion stimuli. Contrary to expectations from psychophysics, these results suggest that in the human visual cortex, the direction of 2nd-order motion is represented as early as V1. In addition, we found no obvious anatomical segregation in the neural substrates for 1st- and 2nd-order motion processing that can be resolved using standard fMRI.
The role of titin in eccentric muscle contraction

Muscle contraction and force regulation in skeletal muscle have been thought to occur exclusively through the relative sliding of and the interaction between the contractile filaments actin and myosin. While this two-filament sarcomere model has worked well in explaining the properties of isometrically and concentrically contracting muscle, it has failed miserably in explaining experimental observations in eccentric contractions. Here, I suggest, and provide evidence, that a third filament, titin, is involved in force regulation of sarcomeres by adjusting its stiffness in an activation-dependent (calcium) and active force-dependent manner. Upon muscle activation, titin binds calcium at specific sites, thereby increasing its stiffness, and cross-bridge attachment to actin is thought to free up binding sites for titin on actin, thereby reducing titin's free-spring length, thus increasing its stiffness and force upon stretch of active muscle. This role of titin as a third force regulating myofilament in sarcomeres, although not fully proven, would account for many of the unexplained properties of eccentric muscle contraction, while simultaneously not affecting the properties predicted by the two-filament cross-bridge model in isometric and concentric muscle function. Here, I identify the problems of the two-filament sarcomere model and demonstrate the advantages of the three-filament model by providing evidence of titin's contribution to active force in eccentric muscle function.
A probabilistic-constrained leakage-based beamforming for downlink multiple stream MU-MIMO system

Multi-user multiple-input and multiple-output (MU-MIMO) wireless system has the potential to provide a substantial gain by using transmit beamforming. The main challenge for transmit beamforming design is to suppress the interference from other users/data with imperfect channel state information at transmitter (CSIT). We propose a probabilistic-constrained beamforming design that combines the SLNR criteria with Alamouti coding for the multiple-stream-per-user MU-MIMO system. The proposed beamformer maximizes the average system performance and exterminates inter-data-interference while guaranteeing a low outage probability of serious leakage power performance. Simulation results show that the proposed beamformer achieves the highest signal-to-interference-and-noise ratio (SINR) reliability and provides the strongest robustness against channel imperfections, among the state-of-art transmit beamformers.
Factorial Validity and Invariance of a Survey Measuring Psychosocial Correlates of Colorectal Cancer Screening among African Americans and Caucasians

Background: Psychosocial constructs are widely used to predict colorectal cancer screening and are targeted as intermediate outcomes in behavioral intervention studies. Reliable and valid instruments for measuring general colorectal cancer screening psychosocial constructs are needed; yet, few studies have conducted psychometric analyses. This study replicated a five-factor structure for 16 theory-based, general colorectal cancer screening items measuring salience and coherence, cancer worries, perceived susceptibility, response efficacy, and social influence. In addition, we examined factorial invariance across race and sex. Methods: African American and Caucasian patients (n = 1,413) attending an urban, primary care clinic were included in this study. These individuals completed a baseline survey as part of a colorectal cancer screening intervention trial. Single and multigroup confirmatory factor analyses using maximum-likelihood estimation were done. Results: The five-factor general colorectal cancer screening model provided excellent fit and was invariant across race-sex subgroups. Conclusions: The findings of invariance across sex and race subgroups support the use of these scales to measure group differences. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2855-61)
Identification of genes that are essential to restrict genome duplication to once per cell division

Nuclear genome duplication is normally restricted to once per cell division, but aberrant events that allow excess DNA replication (EDR) promote genomic instability and aneuploidy, both of which are characteristics of cancer development. Here we provide the first comprehensive identification of genes that are essential to restrict genome duplication to once per cell division. An siRNA library of 21,584 human genes was screened for those that prevent EDR in cancer cells with undetectable chromosomal instability. Candidates were validated by testing multiple siRNAs and chemical inhibitors on both TP53+ and TP53- cells to reveal the relevance of this ubiquitous tumor suppressor to preventing EDR, and in the presence of an apoptosis inhibitor to reveal the full extent of EDR. The results revealed 42 genes that prevented either DNA re-replication or unscheduled endoreplication. All of them participate in one or more of eight cell cycle events. Seventeen of them have not been identified previously in this capacity. Remarkably, 14 of the 42 genes have been shown to prevent aneuploidy in mice. Moreover, suppressing a gene that prevents EDR increased the ability of the chemotherapeutic drug Paclitaxel to induce EDR, suggesting new opportunities for synthetic lethalities in the treatment of human cancers.
Exploring the spectroscopic diversity of Type Ia supernovae with dracula: a machine learning approach

The existence of multiple subclasses of type Ia supernovae (SNeIa) has been the subject of great debate in the last decade. One major challenge inevitably met when trying to infer the existence of one or more subclasses is the time consuming, and subjective, process of subclass definition. In this work, we show how machine learning tools facilitate the automatic discovery of sub-populations of SNIa; to that end we introduce the DRACULA Python package (Dimensionality Reduction And Clustering for Unsupervised Learning in Astronomy). Our approach is divided in three steps: (i) Transfer Learning, which takes advantage of all available spectra (even those without an epoch estimate) as an information source, (ii) dimensionality reduction through Deep Learning and (iii) unsupervised learning (clustering) using K-Means. Results match a previously suggested classification scheme, showing that the proposed method is able to grasp the main spectral features behind the definition of such subclasses. Moreover, our methodology is capable of automatically identifying a hierarchical structure of spectral features. This allows the confirmation of the velocity of lines as a first order effect in the determination of SNIa sub-classes, followed by 91bg-like events. In this context, SNIa spectra are described by a space of 4 dimensions + 1 for the time evolution of objects. We interpreted this as evidence that the progenitor system and the explosion mechanism should be described by a small number of initial physical parameters. Given the expected data deluge in the forthcoming years, our proposed approach is essential to allow a quick and statistically coherent identification of subclasses (and outliers). DRACULA is publicly available within COINtoolbox (https://github.com/COINtoolbox/DRACULA).
First Evidence of Dinosaurian Secondary Cartilage in the Post-Hatching Skull of Hypacrosaurus stebingeri (Dinosauria, Ornithischia)

Bone and calcified cartilage can be fossilized and preserved for hundreds of millions of years. While primary cartilage is fairly well studied in extant and fossilized organisms, nothing is known about secondary cartilage in fossils. In extant birds, secondary cartilage arises after bone formation during embryonic life at articulations, sutures and muscular attachments in order to accommodate mechanical stress. Considering the phylogenetic inclusion of birds within the Dinosauria, we hypothesized a dinosaurian origin for this “avian” tissue. Therefore, histological thin sectioning was used to investigate secondary chondrogenesis in disarticulated craniofacial elements of several post-hatching specimens of the non-avian dinosaur Hypacrosaurus stebingeri (Ornithischia, Lambeosaurinae). Secondary cartilage was found on three membrane bones directly involved with masticatory function: (1) as nodules on the dorso-caudal face of a surangular; and (2) on the bucco-caudal face of a maxilla; and (3) between teeth as islets in the alveolar processes of a dentary. Secondary chondrogenesis at these sites is consistent with the locations of secondary cartilage in extant birds and with the induction of the cartilage by different mechanical factors - stress generated by the articulation of the quadrate, stress of a ligamentous or muscular insertion, and stress of tooth formation. Thus, our study reveals the first evidence of “avian” secondary cartilage in a non-avian dinosaur. It pushes the origin of this “avian” tissue deep into dinosaurian ancestry, suggesting the creation of the more appropriate term “dinosaurian” secondary cartilage.