Miracle-dz/UniFAR-FTUs huggingface dataset:
The Shuttle Nanoelectromechanical Nonvolatile Memory

Nonvolatile memory (NVM) devices based on storage layers, p-n junctions and transistors, such as FLASH, suffer from poor retention at high temperature, high voltage writing, and wear out while cycling. This paper presents the structure, operation, and modeling of a nanoelectromechanical NVM based on the switching of a free electrode between two stable states. This electrode, called the shuttle, has no mechanical anchors and commutes between two positions. It is guided inside an insulator pod. Adhesion forces between the shuttle and fixed electrodes serve to hold the shuttle in stable positions. Smooth metal layers give strong Van der Waals stiction between two surfaces in contact. Memory detection is obtained by probing the conductance between two fixed contacts; the shuttle serves as a switchable open/short electrode. Electromechanical contacts have an ideally large resistance ratio between on and off levels. At microscale, gravity is found to be negligible compared with adhesion forces, which motivates the anchorless design for high-temperature data storage. The model proposed is based on charge induction over the surface of metal electrodes and is validated by finite-element method. Kinematic equations and energy transfers of the shuttle device are explored. Due to its unique anchorless design, the scalability of the anchorless shuttle memory is found to be excellent.
Competition Over Agents with Boundedly Rational Expectations

I study a market model in which profit-maximizing firms compete in multi-dimensional pricing strategies over a consumer, who is limited in his ability to grasp such complicated objects and therefore uses a sampling procedure to evaluate them. Firms respond to increased competition with an increased effort to obfuscate, rather than with more competitive pricing. As a result, consumer welfare is not enhanced and may even deteriorate. Specifically, when firms control both the price and the quality of each dimension, and there are diminishing returns to quality, increased competition implies an efficiency loss which is entirely borne by consumers.
Assessment of three minimally invasive continuous cardiac output measurement methods in critically ill patients and a review of the literature.

BACKGROUND In this study we compared the accuracy of three continuous cardiac output (CCO) measurement methods, with intermittent transcardiopulmonary thermodilution (TPTD-CO) as the gold standard. The three studied CCO measurement methods were: uncalibrated peripheral pulse contour measurement (FCCO), calibrated central pulse contour measurement (PCCO), and CCO obtained by indirect Fick principle (NCCO). METHODS We performed an observational study in 23 critically ill patients. Statistical analysis was done using Pearson's correlation and Bland-Altman analysis. A review of the relevant medical literature was performed. RESULTS Only PCCO showed good correlation (R = 0.9) and agreement with a bias of 0.0 ± 0.8 L min⁻¹ and percentage error of 24.5% when compared to TPTD-CO. In patients with normal systemic vascular resistance index (SVRI > 1,700 dyne sec cm⁻⁵ m⁻²), NCCO (R = 0.8 and bias 0.4 ± 1.3 L min⁻¹) and FCCO (R = 0.8 and bias 0.1 ± 1 L min⁻¹) also produced reliable results. CONCLUSIONS These results indicate that in our patient population, CCO can be most reliably monitored by calibrated central pulse contour measurements. All other methods appeared less accurate, especially in situations of low SVRI.
Energy-efficient approximate wallace-tree multiplier using significance-driven logic compression

In this paper, we propose an energy-efficient approximate multiplier design approach. Fundamental to this approach is configurable lossy logic compression, coupled with low-cost error mitigation. The logic compression is aimed at reducing the number of product rows using progressive bit significance, and thereby decreasing the number of reduction stages in Wallace-tree accumulation. This accounts for substantially lower number of logic counts and lengths of the critical paths at the cost of errors in lower significant bits. These errors are minimised through a parallel error detection logic and compensation vector. To validate the effectiveness of our approach, multiple 8-bit multipliers are designed and synthesized using Synopses Design Compiler with different logic compression levels. Post synthesis experiments showed the trade-offs between energy and accuracy for these compression levels, featuring up to 70% reduction in power-delay product (PDP) and 60% lower area in the case of a multiplier with 4-bit logic compression. These gains are achieved at a low loss of accuracy, estimated at less than 0.0554 of mean relative error. To demonstrate the impact of approximation on a real application, a case study of image convolution filter was extensively investigated, which showed up to 62% (without error compensation) and 45% (with error compensation) energy savings when processing image with a multiplier using 4-bit logic compression.
Family History, Mammographic Density, and Risk of Breast Cancer

Purpose: Mammographic density is a strong and highly heritable risk factor for breast cancer. The purpose of this study was to examine the extent to which mammographic density explains the association of family history of breast cancer with risk of the disease. Subjects and Methods: We carried out three nested case-control studies in screening programs that included in total 2,322 subjects (1,164 cases and 1,158 controls). We estimated the independent and combined associations of family history and percent mammographic density at baseline with subsequent breast cancer risk. Results: After adjustment for age and other risk factors, compared with women with no affected first-degree relatives, percent mammographic density was 3.1% greater for women with one affected first-degree relative, and 7.0% greater for women with two or more affected relatives (P = 0.001 for linear trend across family history categories). The odds ratios for breast cancer risk were 1.37 [95% confidence interval (95% CI), 1.10-1.72] for having one affected relative, and 2.45 (95% CI, 1.30-4.62) for having two or more affected relatives (P for trend = 0.0002). Adjustment for percent mammographic density reduced these odds ratios by 16% and 14%, respectively. Percent mammographic density explained 14% (95% CI, 4-39%) of the association of family history (at least one affected first-degree relative) with breast cancer risk. Conclusions: Percent mammographic density has features of an intermediate marker for breast cancer, and some of the genes that explain variation in percent mammographic density might be associated with familial risk of breast cancer. Cancer Epidemiol Biomarkers Prev; 19(2); 456–63
Is Acculturation Unidimensional or Bidimensional ? A Head-to-Head Comparison in the Prediction of Personality , Self-Identity , and Adjustment

The unidimensional model of acculturation posits that heritage and mainstream culture identifications have a strong inverse relation, whereas the bidimensional model posits that the 2 identifications are independent. The authors compared these models in 3 samples of ethnic Chinese (ns = 164, 150, and 204), 1 sample of non-Chinese East Asians (n = 70), and one diverse group of accultumting individuals (n = 140). Although the unidimensional measure showed a coherent pattern of external correlates, the bidimensional measure revealed independent dimensions corresponding to heritage and mainstream culture identification. These dimensions displayed patterns of noninverse correlations with personality, self-identity, and psychosocial adjustment. The authors conclude that the bidimensional model is a more valid and useful operationalization of acculturation.
Studies in software cost model behavior: do we really understand cost model performance

While there exists extensive literature on software cost estimation techniques, industry practice continues to rely upon standard regression-based algorithms. These software effort models are typically calibrated or tuned to local conditions using local data. This paper cautions that current approaches to model calibration often produce sub-optimal models because of the large variance problem inherent in cost data and by including far more effort multipliers than the data supports. Building optimal models requires that a wider range of models be considered while correctly calibrating these models requires rejection rules that prune variables and records and use multiple criteria for evaluating model performance. The main contribution of this paper is to document a standard method that integrates formal model identification, estimation, and validation. It also documents what we call the large variance problem that is a leading cause of cost model brittleness or instability.
Translating pressure ulcer guidelines into practice: it's harder than it sounds.

OBJECTIVE To determine the cost-effectiveness of a guideline-based pressure ulcer prevention protocol over time. DESIGN Retrospective and prospective quasi-experimental longitudinal design. Costs are presented from the long-term-care facility perspective. Data collection occurred for 3 periods: the first 6 months of 1994 (prior to protocol implementation), the first 6 months of 1995 (immediately following implementation) and the first 6 months of 1997 (2 years following implementation). SETTING 77-bed long-term-care facility PATIENTS/PARTICIPANTS Subjects were ulcer-free facility residents at the start of each data collection period. There were 69 subjects in the 1994 sample, 63 in the 1995 sample, and 71 in the 1997 sample. INTERVENTIONS A guideline-based pressure ulcer prevention protocol was implemented during the last 3 months of 1994. The protocol consisted of specific policies for pressure ulcer prevention and treatment, intensive staff education on pressure ulcer care, and monitoring with regular performance feedback to staff. MEASUREMENTS AND MAIN RESULTS Time to ulcer development varied among the 3 groups (log rank = 8.81, P = .01), with longer time to ulcer development in 1995 compared with 1994; no difference was seen between 1997 and 1994. The time for ulcers to heal decreased over the 3 years (log rank = 9.49, P <.01), with ulcer healing time being shorter in 1995 and 1997 compared with 1994. Total costs were unchanged during the 3 years (F = 0.2, P =.81). Costs of treatment declined significantly from 1994 to 1995 and 1997 (F = 5.5, P <.01) and costs of prevention increased significantly from 1994 to 1995 and 1997(F = 15, P <.01). From 1994 to 1997, the cost for 1 day of ulcer-free life was $3.50. CONCLUSIONS Implementation of a pressure ulcer prevention protocol showed mixed results. Initial reductions in pressure ulcer incidence were lost over time. Clinical results of ulcer treatment, however, improved and treatment costs fell during the 3 years. Implementation of preventive programs poses a major leadership challenge.
Compiler-based adaptive fetch throttling for energy-efficiency

Front-end instruction delivery accounts for a significant fraction of energy consumption in dynamically scheduled superscalar processors. Different front-end throttling techniques have been introduced to reduce the chip-wide energy consumption caused by redundant fetching. Hardware-based techniques, such as flow-based throttling, could reduce the energy consumption considerably, but with a high performance loss. On the other hand, compiler-based IPC-estimation-driven software fetch throttling (CFT) techniques result in relatively low performance degradation, which is desirable for high-performance processors. However, their energy savings are limited by the fact that they typically use a predefined fixed low IPC-threshold to control throttling. In this paper, we propose a compiler-based adaptive fetch throttling (CAFT) technique that allows changing the throttling threshold dynamically at runtime. Instead of using a fixed threshold, our technique uses the decode/issue difference (DID) to assist the fetch throttling decision based on the statically estimated IPC. Changing the threshold dynamically makes it possible to throttle at a higher estimated IPC, thus increasing the throttling opportunities and resulting in larger energy savings. We demonstrate that CAFT could increase the energy savings significantly compared to CFT, while preserving its benefit of low performance loss. Our simulation results show that the proposed technique doubles the energy-delay product (EDP) savings compared to the fixed threshold throttling and achieves a 6.1% average EDP saving.
Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells

Significance This study shows that caffeine's effect on gastric acid secretion (GAS) is more complex than has been previously thought. Oral and gastric bitter taste receptors are involved in the regulation of GAS in humans. This regulatory process can be modified by the bitter-masking compound homoeriodictyol. Practical applications of the results may include treatment of gastroesophageal reflux disease or peptic ulcer by manipulating gastric pH by means of bitter tastants and inhibitors. Caffeine, generally known as a stimulant of gastric acid secretion (GAS), is a bitter-tasting compound that activates several taste type 2 bitter receptors (TAS2Rs). TAS2Rs are expressed in the mouth and in several extraoral sites, e.g., in the gastrointestinal tract, in which their functional role still needs to be clarified. We hypothesized that caffeine evokes effects on GAS by activation of oral and gastric TAS2Rs and demonstrate that caffeine, when administered encapsulated, stimulates GAS, whereas oral administration of a caffeine solution delays GAS in healthy human subjects. Correlation analysis of data obtained from ingestion of the caffeine solution revealed an association between the magnitude of the GAS response and the perceived bitterness, suggesting a functional role of oral TAS2Rs in GAS. Expression of TAS2Rs, including cognate TAS2Rs for caffeine, was shown in human gastric epithelial cells of the corpus/fundus and in HGT-1 cells, a model for the study of GAS. In HGT-1 cells, various bitter compounds as well as caffeine stimulated proton secretion, whereby the caffeine-evoked effect was (i) shown to depend on one of its cognate receptor, TAS2R43, and adenylyl cyclase; and (ii) reduced by homoeriodictyol (HED), a known inhibitor of caffeine’s bitter taste. This inhibitory effect of HED on caffeine-induced GAS was verified in healthy human subjects. These findings (i) demonstrate that bitter taste receptors in the stomach and the oral cavity are involved in the regulation of GAS and (ii) suggest that bitter tastants and bitter-masking compounds could be potentially useful therapeutics to regulate gastric pH.
Estimation of Vaccine Efficacy and Critical Vaccination Coverage in Partially Observed Outbreaks

Classical approaches to estimate vaccine efficacy are based on the assumption that a person's risk of infection does not depend on the infection status of others. This assumption is untenable for infectious disease data where such dependencies abound. We present a novel approach to estimating vaccine efficacy in a Bayesian framework using disease transmission models. The methodology is applied to outbreaks of mumps in primary schools in the Netherlands. The total study population consisted of 2,493 children in ten primary schools, of which 510 (20%) were known to have been infected, and 832 (33%) had unknown infection status. The apparent vaccination coverage ranged from 12% to 93%, and the apparent infection attack rate varied from 1% to 76%. Our analyses show that vaccination reduces the probability of infection per contact substantially but not perfectly ( = 0.933; 95CrI: 0.908–0.954). Mumps virus appears to be moderately transmissible in the school setting, with each case yielding an estimated 2.5 secondary cases in an unvaccinated population ( = 2.49; 95%CrI: 2.36–2.63), resulting in moderate estimates of the critical vaccination coverage (64.2%; 95%CrI: 61.7–66.7%). The indirect benefits of vaccination are highest in populations with vaccination coverage just below the critical vaccination coverage. In these populations, it is estimated that almost two infections can be prevented per vaccination. We discuss the implications for the optimal control of mumps in heterogeneously vaccinated populations.
Salmonella typhimurium LT2 possesses three distinct 23S rRNA intervening sequences

The rrl genes for 23S rRNA of Salmonella typhimurium LT2 are known to carry intervening sequences (IVSs) at two sites, helix-25 and helix-45, which are excised by RNase III during rRNA maturation, resulting in rRNA which is fragmented but nevertheless functional. We isolated DNA fragments containing the seven rrl genes from BlnI, I-CeuI, and SpeI genomic digests following pulsed-field gel electrophoresis and used these DNA fragments as templates for PCRs utilizing primers upstream and downstream of helix-25 and helix-45. Variance in amplicon length and cycle sequencing indicated that rrlG and rrlH have IVSs in helix-25 of approximately 110 bp which are only 56% identical. rrnA, rrnB, rrnC, rrnD, rrnE, and rrnH have IVSs of approximately 90 bp in helix-45, and all have the same nucleotide sequence. Twenty-one independent wild-type strains of S. typhimurium from Salmonella Reference Collection A were analyzed for IVSs by using PCRs with genomic DNAs and by denaturing agarose electrophoresis of RNAs. Many strains resemble LT2, but some have no IVSs in helix-25 and others have IVSs in helix-45 in all seven rrl genes. However, the IVSs in individual wild-type lines are relatively stable, for several LT2 isolates separated over many years by many single-colony isolations are indistinguishable from one another, with the exception of line LB5010, which differs by one helix-25 IVS. We postulate that IVSs have entered strain LT2 by three independent lateral-transfer events and that the IVS in helix-45 was dispersed to and maintained in the same sequence in six of the seven rrl genes by the mechanism of gene conversion.
Controlling iterative software development projects: the challenge of stakeholder and technical integration

Most IS projects today are not greenfield projects, but relate heavily to existing information infrastructures and business processes. How should the development process integrate with the business process? This is a crucial question, because a project that does not integrate with the business processes is a failure, even if the software which is produced is well designed and programmed. The software engineering community has embraced iterative process frameworks, like the rational unified process. These frameworks claim to support a step-wise integration of the business process and the development process. This paper explores and analyses the managerial challenges of integration in such projects. Building on a longitudinal case study and an analysis of the rational unified process, four types of integration are identified and analyzed: external and internal stakeholder integration, and internal and external technical integration. Finding that the external integration mechanisms are just as critical at the internal, the paper concludes that the integration challenge is complex, partly outside the control of the project manager and not supported sufficiently in the RUP framework. A theory extension to RUP is suggested.
Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum

The cartilaginous fish are the oldest phylogenetic group in which all of the molecular components of the adaptive immune system have been found. Although early studies clearly showed that sharks could produce an IgM‐based response following immunization, evidence for memory, affinity maturation and roles for the other isotypes (notably IgNAR) in this group remained inconclusive. The data presented here illustrate that the nurse shark (Ginglymostoma cirratum) is able to produce not only an IgM response, but we also show for the first time a highly antigen‐specific IgNAR response. Additionally, under appropriate conditions, a memory response for both isotypes can be elicited. Analysis of the response shows differential expression of pentameric and monomeric IgM. Pentameric IgM provides the ‘first line of defense’ through high‐avidity, low‐affinity interaction with antigen. In contrast, monomeric IgM and IgNAR seem responsible for the specific, antigen‐driven response. We propose the presence of distinct lineages of B cells in sharks. As there is no conventional isotype switching, each lineage seems pre‐determined to express a single isotype (IgM versus IgNAR). However, our data suggest that there may also be specific lineages for the different forms (pentameric versus monomeric) of the IgM isotype.
Hierarchical and graphical analysis of fMRI network connectivity in healthy and schizophrenic groups

Understanding the changes or disruption in the connectivity among brain networks is important for identifying potential biological markers for neuropsychiatric diseases. Multivariate and data-driven methods, especially independent component analysis (ICA), have proven to be a powerful tool in this field. Here, we introduce a novel analysis scheme that incorporates hierarchical and graphical techniques to study the connectivity differences between healthy controls and schizophrenia patients, using the spatial dependence among ICA components as an index of network connectivity. We find that compared to healthy controls, the schizophrenic group presents an altered hierarchy with a number of unusual connections and a significantly decreased small-world index, suggesting disease-related changes in the organization of brain connectivity.
Aliasing of high‐frequency variability by altimetry: Evaluation from bottom pressure recorders

In spectra computed from bottom pressure records, 18% to 63% of non‐tidal energy is associated with frequencies greater than 1 cycle per 20 days, the approximate Nyquist frequency for the TOPEX/Poseidon (T/P) satellite. Since bottom pressure measurements are correlated with coincident sea surface height measurements from the T/P satellite, hourly bottom pressure data are used here to characterize the aliasing expected from T/P. As numerical modeling studies have also demonstrated, spectra computed from data sampled at 10‐day intervals are likely to alias substantial amounts of unresolved high‐frequency variability, particularly at frequencies greater than 0.2 times the Nyquist frequency.
Shape-dynamic growth, structure, and elasticity of homogeneously oriented spherulites in an isotropic/smectic-A mesophase transition

A Landau-de Gennes model that integrates the nematic quadrupolar tensor order parameter and complex smectic-A order parameters is used to simulate the two-dimensional growth of an initially homogeneous smectic-A spherulite in an isotropic matrix. These simulations are performed in the shape-dynamic (nano-scale) regime of growth under two material conditions: isotropic nematic elasticity and equal splay-bend nematic elasticity. A comparison of the growth kinetics, spherulite morphology, and interfacial/bulk energy landscapes between both cases is made showing that equal nematic splay–bend elasticity is required to reproduce past experimental and theoretical observations. In addition, a previously unknown undulation instability during spherulite growth is found which, in conjunction with preferred planar anchoring and defect shedding mechanisms at micrometer length scales, could explain the formation mechanism of focal conic curvature defects and ultimately smectic-A ‘batonnet’ structures observed experimentally.