Miracle-dz/UniFAR-FTUs huggingface dataset:
Amniotic Membrane Transplantation in Reconstructive and Regenerative Ophthalmology

Background The goal of this study was to investigate numbers, indications, surgical techniques, and experiences of amniotic membrane transplantation at the University Eye Hospital Tübingen over the last 16 years. Material/Methods Data from all amniotic membrane transplantations from January 2001 to December 2016 were retrospectively analyzed. Data was accessed from the electronic database and the annual reports of the Eye Bank at the University Eye Hospital Tübingen. Results A total of 771 amniotic membrane transplantations were performed between 2001 and 2016 at the University Eye Hospital Tübingen. The mean number of amniotic membrane transplantations was 48 per year (range: 7–81). Overall, the mean number of amniotic membrane transplantations more than doubled, from 31 amniotic membrane transplantations per year during the first 8-year period to 66 amniotic membrane transplantations per year during the second 8-year period (p<0.0001). The most common surgical indications for amniotic membrane transplantation were corneal ulcers and persistent corneal epithelial defects. The inlay, overlay, and sandwich technique became the favored surgical methods for various disorders of the ocular surface. Conclusions Our study showed a significant increase of amniotic membrane transplantations from 2001 to 2016. This increase is likely influenced by the introduction of different surgical amniotic membrane transplantation techniques, the rising knowledge about containing growth factors, neurotrophins and cytokines, and the demographic change with aging of the population.
Dynamics of adaptive immunity against phage in bacterial populations

The CRISPR (clustered regularly interspaced short palindromic repeats) mechanism allows bacteria to adaptively defend against phages by acquiring short genomic sequences (spacers) that target specific sequences in the viral genome. We propose a population dynamical model where immunity can be both acquired and lost. The model predicts regimes where bacterial and phage populations can co-exist, others where the populations exhibit damped oscillations, and still others where one population is driven to extinction. Our model considers two key parameters: (1) ease of acquisition and (2) spacer effectiveness in conferring immunity. Analytical calculations and numerical simulations show that if spacers differ mainly in ease of acquisition, or if the probability of acquiring them is sufficiently high, bacteria develop a diverse population of spacers. On the other hand, if spacers differ mainly in their effectiveness, their final distribution will be highly peaked, akin to a “winner-take-all” scenario, leading to a specialized spacer distribution. Bacteria can interpolate between these limiting behaviors by actively tuning their overall acquisition probability.
Safer paediatric surgical teams: A 5-year evaluation of crew resource management implementation and outcomes

Objective Evaluate longitudinal changes in technical and non-technical skills (teamwork, situation monitoring, communication and leadership), safety culture, and clinical outcomes before and after implementation of a crew resource management (CRM) safety program. Design A multi-level prospective single case study in accordance with the SQUIRE-guidelines for reporting quality improvement efforts. Setting Large university paediatric surgical service. Participant(s) All 153 managers and staff. Interventions Training of staff in CRM, systematic risk assessments, and the redesign of work practices captured and reinforced through the development, implementation and refinement of SOPs. Main Outcome Measure(s) Data were collected related to: 1) Relevance of CRM training (survey), 2) Safety culture (survey), 3) Team behaviours in clinical practice (non-participatory observations with MedPACT protocol) and 4) Effects on perioperative care for laparoscopic appendectomies-a representative and frequently performed surgical procedure (electronic medical records and administrative data for length of stay, unplanned readmissions and returns to the Operating Room). Results Non-technical skills, the use of safety tools, as well as adherence to guidelines for appendectomies all improved significantly over time. Significant safety culture improvements were found in teamwork across and within units, supervisors' expectations and actions, non-punitive response to adverse events, and perceptions of overall patient safety. Unplanned readmissions following appendectomy declined significantly. Conclusions Implementation of a comprehensive CRM program including associated safety tools created sustained adherence to new work practices and improved non-technical and technical skills, surgical outcomes and safety culture.
Haemodialysis acutely deteriorates left and right diastolic function and myocardial performance: an effect related to high ultrafiltration volumes?

Background The effect of acute preload reduction during haemodialysis on left ventricle (LV) and right ventricle (RV) function is not well understood. This study aimed to evaluate acute changes in novel echocardiographic and tissue Doppler-derived indices of LV and RV function during the first and a standard weekly dialysis session and to examine the possible effect of acute intradialytic volume changes in LV and RV diastolic function and pulmonary circulation loading. Methods Forty-one adult patients receiving standard thrice-weekly haemodialysis participated in this study. Two-dimensional echocardiographic and tissue Doppler imaging (TDI) studies were performed with a standard cardiac ultrasound device (Vivid 7 or Vivid e, GE, Horton, Norway) shortly before and after the first weekly and a standard dialysis session. Multiple linear regression analysis was applied to assess the effect of volume changes on peak early mitral (E) and tricuspid (E RV) velocities changes. Results Significant reductions from pre- to post-haemodialysis were noted in body weight and systolic blood pressure. Post-haemodialysis left and right atrial, LV and RV sizing echocardiographic parameters were lower. LV systolic function, represented by LV ejection fraction, cardiac output and mean peak systolic LV and RV velocities at the annulus level, was unchanged. Diastolic function indices such as E (first session: 0.96 ± 0.28 versus 0.75 ± 0.27 m/s, P < 0.001; standard session: 0.89 ± 0.24 versus 0.78 ± 0.29, P < 0.001) and E RV (first session: 0.89 ± 0.26 versus 0.67 ± 0.25 m/s, P < 0.001; standard session: 0.86 ± 0.24 versus 0.77 ± 0.31, P < 0.001), E/A LV ratio, TDI peak early mitral (E') velocity and E'/A' RV ratio were reduced after haemodialysis. Pulmonary circulation loading, represented by RV systolic pressure, was significantly improved. In multiple regression model analysis, intradialytic weight loss was independently associated with changes in E [β = 0.042 (95% CI 0.018-0.066)] and E RV [β = 0.084 (95% CI 0.057-0.110)]. Conclusions This study shows that haemodialysis deteriorates cardiac diastolic function indices and improves pulmonary circulation loading, while systolic function remains unchanged. High intradialytic volume removal may affect cardiac diastolic function.
Microbiologically-Induced Soil Stabilization: Application of Sporosarcina pasteurii for Fugitive Dust Control

In this study, we have introduced a biological dust control technique utilizing a naturally occurring soil microorganism, Sporosarcina pasteurii, which is capable of inducing calcium carbonate precipitation in the environment. To evaluate the dust suppressive potential of this microbial calcite, S. pasteurii was suspended in medium and applied to locally available sand. The treated soil samples were tested via a wind tunnel at intervals and mass losses were measured. In order to identify the optimum conditions of microbial dust suppression, we examined the effects of: a) the concentration of S. pasteurii, b) the temperature and humidity, and c) the soil preparation method (washed or unwashed). Both types of the soil samples treated with S. pasteurii formed a crust-like layer on the surface and showed a significant reduction in mass loss. Our study demonstrated the potential of this microbiallymediated process as an effective, environmentally friendly means of airborne fugitive dust control.
Characterization of the Resistance and Force of a Carbon Nanotube/Metal Side Contact by Nanomanipulation

A high contact resistance restricts the application of carbon nanotubes (CNTs) in fabrication of field-effect transistors (FETs). Thus, it is important to decrease the contact resistance and investigate the critical influence factors such as the contact length and contact force. This study uses nanomanipulation to characterize both the resistance and the force at a CNT/Au side-contact interface inside a scanning electron microscopy (SEM). Two-terminal CNT manipulation methods, and models for calculating the resistance and force at contact area, are proposed to guide the measurement experiments of a total resistance and a cantilever's elastic deformation. The experimental results suggest that the contact resistance of CNT/Au interface is large (189.5 kΩ) when the van der Waals force (282.1 nN) dominates the contact force at the interface. Electron-beam-induced deposition (EBID) is then carried out to decrease the contact resistance. After depositing seven EBID points, the resistance is decreased to 7.5 kΩ, and the force increases to 1339.8 nN at least. The resistance and force at the contact area where CNT was fixed exhibit a negative exponential correlation before and after EBID. The good agreement of this correlation with previous reports validates the proposed robotic system and methods for characterizing the contact resistance and force.
Traumatic life events and development of post-traumatic stress disorder among female factory workers in a developing country

Background: Post-traumatic stress disorder (PTSD) may be more prevalent and burdensome in developing countries. Aims: The goals of this study were to (1) determine the prevalence of PTSD, (2) identify types and number of traumas related to screening positive for PTSD and (3) determine other sociodemographic risk factors and health/medical conditions that may be correlated to PTSD among garment-factory workers and a comparable working population in Bangladesh. Method: A survey was administered to a convenient sample of 607 lower socio-economic status (SES) working women in Bangladesh, 310 of who were garment workers. The primary outcome PTSD was measured by the PTSD Checklist. The Life Events Checklist determined the number and type of traumatic events. Results: The prevalence of PTSD was found to be 17.79% – 7.25% in garment workers and 21.55% in the comparison worker group. In multivariate analysis, PTSD was found to be significantly associated with age, income, chronic pain and number of stressful events. Participants between 45–50 years of age had the greatest odds of reporting PTSD – 15.68 fold (95% confidence interval (CI) = 4.08, 60.29) compared with those younger than 24 years. PTSD was more common in those with lower income (2,000–4,000 taka) (odds ratio (OR) = 1.60; 95% CI = 0.79, 3.26), who had chronic pain (OR = 2.48; 95% CI = 1.51, 4.07) and who experienced over three traumatic life events (OR = 11.25; 95% CI = 4.59, 27.59). The mean number of traumatic events experienced by this entire population was 4.9 with PTSD being more likely in those who experienced physical assault (OR = 6.35; 95% CI = 4.07, 9.90), who caused serious harm or death to someone else (OR = 4.80; 95% CI = 1.36, 16.87) and who had exposure to combat or war (OR = 4.76; 95% CI = 1.17, 19.34). Conclusion: Undiagnosed and untreated PTSD impacts the quality of life and decrease worker productivity among working-age women in this developing country.
THE GROWTH OF SHORT CRACKS UNDER CYCLIC COMPRESSION

The fatigue crack growth behaviour, the length of the arrested cracks and the shape of the crack front were investigated for cyclic compression. Specimens with deep sharp notches were used. The experiments were performed for different load amplitudes and load ratios under conditions of small scale yielding. The material used was ARMCO-iron. The growth rate and length of the arrested cracks were estimated and compared with the experimental results. The crack growth rate of very short cracks is determined by the stress intensity and is independent of the stress ratio. The length of the arrested cracks depends on the stress ratio and is bounded by the size of the cyclic and the monotonic plastic zones.
Visual Explanations From Deep 3D Convolutional Neural Networks for Alzheimer's Disease Classification

We develop three efficient approaches for generating visual explanations from 3D convolutional neural networks (3D-CNNs) for Alzheimer's disease classification. One approach conducts sensitivity analysis on hierarchical 3D image segmentation, and the other two visualize network activations on a spatial map. Visual checks and a quantitative localization benchmark indicate that all approaches identify important brain parts for Alzheimer's disease diagnosis. Comparative analysis show that the sensitivity analysis based approach has difficulty handling loosely distributed cerebral cortex, and approaches based on visualization of activations are constrained by the resolution of the convo-lutional layer. The complementarity of these methods improves the understanding of 3D-CNNs in Alzheimer's disease classification from different perspectives.
Dynamic forecasts of financial distress of Australian firms

Dynamic forecasts of financial distress have received far less attention than static forecasts, particularly in Australia. This study, therefore, investigates dynamic probability forecasts for Australian firms. Novel features of the modelling are the use of time-varying variables in forecasts from a Cox model. Not only is this one of relatively few studies to apply dynamic variables in forecasting financial distress, but to the authors’ knowledge it is the first to provide forecasts of survival probabilities using the Cox model with time-varying variables. Forecast accuracy is evaluated using receiver operating characteristics curves and the Brier Score. It was found that the dynamic model had superior predictive power, in out-of-sample forecasts, to the traditional Cox model and to the logit model.
Myofascial Trigger Points: Translating Molecular Theory into Manual Therapy

Abstract Theories regarding the molecular pathophysiology of myofascial trigger points (MFTrPs) have undergone fundamental revisions in recent years. New research suggests that MFTrPs are evoked by the abnormal depolarization of motor end plates. The motor endplate transduces electrical potential into muscle contraction. This review article expands the proposed etiology to include presynaptic, synaptic, and postsynaptic mechanisms, such as excessive release of acetycholine (ACh), defects of acetylcholinesterase, and upregulation of nicotinic ACh receptors, respectively. Dysfunctional motor endplates and sustained muscular contraction give rise to a localized "ATP energy crisis" associated with sensory and autonomic reflex arcs that is sustained by central sensitization. This working hypothesis has given rise to several new approaches in the treatment of MFTrPs.
Does Japan’s accession to the Trans-Pacific Partnership mean an opportunity or a threat to the US textile industry? A quantitative evaluation

This study provides a quantitative evaluation on the potential impact of the implementation of the Trans-Pacific Partnership (TPP) on the economic interests in the US textile industry, particularly with regard to Japan’s accession to the agreement. By adopting the Global Trade Analysis Project (GTAP) computable general equilibrium model based on the GTAP8 database, results of the study show that: first, trade creation effect of the TPP would result in an increase of the US textile exports to other TPP members; however, with Japan’s accession to the TPP, the potential expansion of the US textile exports would be substantially offset. Second, the TPP would negatively affect the US textile exports to the North American Free Trade Agreement and CAFTA regions, particularly in the case when Japan becomes a TPP member. Third, the TPP would expand the two-way intra-industry trade between the United States and Japan for textiles. Fourth, the TPP would cause an expansion of the trade deficit as well as a decline of domestic production in the US textile industry, particularly in the case when Japan becomes a TPP member. Findings of this study augment our understanding of the Textile and apparel (T&A)-specific sectoral impact of the TPP and provide valuable inputs supporting the T&A sectoral negotiation under the TPP.
Comparison of continuous in situ CO2 observations at Jungfraujoch using two different measurement techniques

Abstract. Since 2004, atmospheric carbon dioxide (CO2) is being measured at the High Altitude Research Station Jungfraujoch by the division of Climate and Environmental Physics at the University of Bern (KUP) using a nondispersive infrared gas analyzer (NDIR) in combination with a paramagnetic O2 analyzer. In January 2010, CO2 measurements based on cavity ring-down spectroscopy (CRDS) as part of the Swiss National Air Pollution Monitoring Network were added by the Swiss Federal Laboratories for Materials Science and Technology (Empa). To ensure a smooth transition – a prerequisite when merging two data sets, e.g., for trend determinations – the two measurement systems run in parallel for several years. Such a long-term intercomparison also allows the identification of potential offsets between the two data sets and the collection of information about the compatibility of the two systems on different time scales. A good agreement of the seasonality, short-term variations and, to a lesser extent mainly due to the short common period, trend calculations is observed. However, the comparison reveals some issues related to the stability of the calibration gases of the KUP system and their assigned CO2 mole fraction. It is possible to adapt an improved calibration strategy based on standard gas determinations, which leads to better agreement between the two data sets. By excluding periods with technical problems and bad calibration gas cylinders, the average hourly difference (CRDS – NDIR) of the two systems is −0.03 ppm ± 0.25 ppm. Although the difference of the two data sets is in line with the compatibility goal of ±0.1 ppm of the World Meteorological Organization (WMO), the standard deviation is still too high. A significant part of this uncertainty originates from the necessity to switch the KUP system frequently (every 12 min) for 6 min from ambient air to a working gas in order to correct short-term variations of the O2 measurement system. Allowing additional time for signal stabilization after switching the sample, an effective data coverage of only one-sixth for the KUP system is achieved while the Empa system has a nearly complete data coverage. Additionally, different internal volumes and flow rates may affect observed differences.
Dietary acrylamide intake and risk of breast cancer: The Japan Public Health Center‐based Prospective Study

Acrylamide forms during cooking and is classified as a probable carcinogen in humans, mandating the need for epidemiological studies of dietary acrylamide and cancers. However, the risk of dietary acrylamide exposure to breast cancer in Japanese women has not been assessed. We investigated the association between dietary acrylamide intake and risk of breast cancer in the Japan Public Health Center‐based Prospective Study. The present study included 48 910 women aged 45‐74 years who responded to a 5‐year follow‐up survey questionnaire. Dietary acrylamide intake was assessed using a validated food frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios and 95% confidence intervals. During an average of 15.4 years of follow up, 792 breast cancers were diagnosed. Energy‐adjusted dietary acrylamide intake was not associated with the risk of breast cancer (adjusted hazard ratio for highest versus lowest tertile = .95, 95% confidence intervals: 0.79‐1.14, P‐trend = .58). Further, no significant associations were observed when stratified analyses were conducted by smoking status, coffee consumption, alcohol consumption, body mass index, menopausal status, estrogen receptor status, and progesterone receptor status. In conclusion, dietary acrylamide intake was not associated with the risk of breast cancer in this population‐based prospective cohort study of Japanese women.
Consonant and Vowel Processing in Word Form Segmentation: An Infant ERP Study

Segmentation skill and the preferential processing of consonants (C-bias) develop during the second half of the first year of life and it has been proposed that these facilitate language acquisition. We used Event-related brain potentials (ERPs) to investigate the neural bases of early word form segmentation, and of the early processing of onset consonants, medial vowels, and coda consonants, exploring how differences in these early skills might be related to later language outcomes. Our results with French-learning eight-month-old infants primarily support previous studies that found that the word familiarity effect in segmentation is developing from a positive to a negative polarity at this age. Although as a group infants exhibited an anterior-localized negative effect, inspection of individual results revealed that a majority of infants showed a negative-going response (Negative Responders), while a minority showed a positive-going response (Positive Responders). Furthermore, all infants demonstrated sensitivity to onset consonant mispronunciations, while Negative Responders demonstrated a lack of sensitivity to vowel mispronunciations, a developmental pattern similar to previous literature. Responses to coda consonant mispronunciations revealed neither sensitivity nor lack of sensitivity. We found that infants showing a more mature, negative response to newly segmented words compared to control words (evaluating segmentation skill) and mispronunciations (evaluating phonological processing) at test also had greater growth in word production over the second year of life than infants showing a more positive response. These results establish a relationship between early segmentation skills and phonological processing (not modulated by the type of mispronunciation) and later lexical skills.