Miracle-dz/UniFAR-FTUs huggingface dataset:
Boost the Reliability of the Linux Kernel: Debugging Kernel Oopses. (Aider le mainteneur d'applications libres à répondre aux rapports d'erreur)

When a failure occurs in the Linux kernel, the kernel emits an error report called “kernel oops”, summarizing the execution context of the failure. Kernel oopses describe real Linux errors, and thus can help prioritize debugging efforts and motivate the design of tools to improve the reliability of Linux code. Nevertheless, the information is only meaningful if it is representative and can be interpreted correctly.In this thesis, we study a collection of kernel oopses over a period of 8 months from a repository that is maintained by Red Hat. We consider the overall features of the data, the degree to which the data reflects other information about Linux, and the interpretation of features that may be relevant to reliability. We find that the data correlates well with other information about Linux, but that it suffers from duplicate and missing information. We furthermore identify some potential pitfalls in studying features such as the sources of common faults and common failing applications.Furthermore, a kernel oops provides valuable first-hand information for a Linux kernel maintainer to conduct postmortem debugging, since it logs the status of the Linux kernel at the time of a crash. However, debugging based on only the information in a kernel oops is difficult. To help developers with debugging, we devised a solution to derive the offending line from a kernel oops, i.e., the line of source code that incurs the crash. For this, we propose a novel algorithm based on approximate sequence matching, as used in bioinformatics, to automatically pinpoint the offending line based on information about nearby machine-code instructions, as found in a kernel oops. Our algorithm achieves 92% accuracy compared to 26% for the traditional approach of using only the oops instruction pointer. We integrated the solution into a tool named OOPSA , which would relieve some burden for the developers with the kernel oops debugging.
Viscoelastic properties of acrylonitrile‐butadiene‐styrene (ABS) polymers in the molten state

The viscoelastic behavior of acrylonitrile-butadiene-styrene (ABS) terpolymers is studied in the molten state. First, the behavior of the styrene-acrylonitrile (SAN) matrix is determined. Then, the effect of the degree of grafting on ABS rheological properties is emphasized. A critical degree of grafting (DGc), corresponding to a minimum of the viscoelastic functions in the low frequency region, is determined. It defines a critical thickness of the grafted layer, and is related to the conformation of the grafted chains at the surface of the rubber particle. The DGc affects the morphology of the ABS and also affects the appearance of a secondary plateau at low frequencies. The effects of the rubber particles, of the grafted chains, and of the morphology on the appearance of the secondary plateau at low frequencies are clearly dissociated.
Lactate dehydrogenase isoenzyme 3 and hemolysis in sickle cell anemia: a possible correlation?

To the editor: The concept that lactate dehydrogenase (LDH) is a useful clinical marker of hemolysis in sickle cell anemia (SCA) is still a subject of debate. [1][1],[2][2] Some previous data suggested that the increase in serum LDH in these patients was mainly due to tissue damage rather than
Microstructure Characterization of Al-Al2O3p Composites Produced By High Energy Ball Milling

Abstract Ultra fine grained composites of an aluminum alloy reinforced with particulate Al2O3 of 5 and 15 vol.% were produced using the high energy ball milling (HEM) method. The changes in size and distribution of particles, i.e. Al2O3 and CuAl2 hard phase, in the aluminum matrix were scrutinized during the milling process, ranging from 10 min to 8 h. Evaluation of the microstructures has shown that after short milling times reinforcing particles are observed rarely inside the matrix powder showing almost no change in particle size but smearing and sticking to the deformed particles. With further milling of composite powders, 2 h and more, the reinforcement particles were broken into small particles becoming finer (less than 1 μm) and more uniformly distributed in the aluminum matrix. SEM investigations also revealed that longer periods of milling lead to ultrafine intermetallic compound phase of CuAl2 within the aluminum matrix, which could be also confirmed by XRD.
Potential of Entomopathogenic Nematodes for Biological Control of Acalymma vittatum (Coleoptera: Chrysomelidae) in Cucumbers Grown in Conventional and Organic Soil Management Systems

Abstract Acalymma vittatum (F.) is the primary insect pest of fresh-market cucumber and melon crops in much of the eastern United States because of their herbivory and interactions with several diseases, most notably bacterial wilt. A study was conducted to determine how soil management affects viability and infectivity of an entomopathogenic nematode that may be used for the control of A. vittatum. Dose-mortality curves under laboratory conditions suggested several Steinernema spp. as potential biocontrol agents. Field injections combined with soil bioassays showed that Steinernema riobravis Cabanillas, Poinar & Raulston (Rhabditus: Steinernematidae) longevity exceeded A. vittatum immature development time in both conventional and organic soil management systems. Mean root length densities of cucumbers increased in both soil management systems with the inclusion of nematodes. Soil management alone also influenced A. vittatum larval survivorship, with higher survival rates in the organic compared with the conventional soil management system. A 50% reduction in A. vittatum larval survival rates in both soil management systems, as determined by adult A. vittatum emergence, demonstrated the potential of incorporation of entomopathogenic nematodes for integrated pest management of diabroticites in commercial cucumber production.
A Modification of Periacetabular Osteotomy Using a Two-Incision Approach

In residual hip dysplasia periacetabular osteotomy (PAO) can improve insufficient coverage of the femoral head. It requires a broad dissection of the pelvic bones and detachment of muscle insertions, however. We have developed a modification of the Bernese periacetabular osteotomy with reduced soft tissue exposure. It uses two small skin incisions and offers therefore the perspective of nicer scars but also increases the risk of technical complications due to impaired vision. To be able to draft these risks, the clinical and radiographic results of 23 patients with PAO through the modified Smith-Petersen approach of Ganz (group A) and 24 patients with our two-incision modification (group B) have been reviewed retrospectively with an average follow-up of 19 (group A) and 12 (group B) months postoperatively. Functional improvement (Harris Hip Score) and center-edge-angle normalization did not differ significantly in both groups. Scars of patients in group B were significantly shorter. However, the overall patient satisfaction (as measured with a visual analogous scale) was the same in both groups. 4 patients in group A and one patient in group B developed superficial or deep wound infections. In conclusion, the experience with our cohort study showed that approach-related morbidity can be reduced without increasing the risk for the individual patient. This observation clearly holds a promise for further minimal invasive approaches as well as for further morbidity reduction of PAO. Level of Evidence: Retrospective comparative study (Level III).
Study of aneuploidy rate and sperm DNA fragmentation in large‐headed, multiple‐tailed spermatozoa

The aim of this study was to analyse the meiotic segregation and DNA fragmentation rates in ejaculated spermatozoa of Tunisian men who presented the macrocephalic sperm head syndrome and to compare the results with those from 20 fertile men with normal semen profiles. Sperm DNA fragmentation was evaluated by the terminal desoxynucleotidyl transferase–mediated deoxyuridine triphosphate biotin nick‐end labelling assay. Fluorescence in situ hybridisation for chromosomes X, Y and 18 was performed for the study of meiotic segregation. Despite a normal blood karyotype, patients with large‐headed spermatozoa showed a significantly higher incidence of sperm chromosomal abnormalities compared with the control group. For all the patients, tetraploidy, triploidy and diploidy were the most observed abnormalities. A very high level of DNA fragmentation was shown for these patients. In conclusion, our results demonstrated that patients with large‐headed, multiple‐tailed spermatozoa had significantly higher incidence of sperm chromosomal abnormalities and very high level of DNA fragmentation. So intracytoplasmic sperm injection should not be recommended to these patients, not only because of its low chances of success rate but also because of its high genetic risk.
Production of exfoliative toxin by isolates of Staphylococcus hyicus from different countries

A total of 218 isolates of Staphylococcus hyicus from pigs in eight countries (Belgium, Croatia, Germany, Japan, Korea, Slovenia, the UK and the USA) and 44 isolates from other animals in Belgium, India, Japan and the USA were examined for the genes encoding the exfoliative toxins ExhA, ExhB, ExhC and ExhD by multiplex PCR. The expression of the toxins was confirmed by immunoblot analysis, using monoclonal or polyclonal antibodies specific for each of the toxins. The porcine isolates were from pigs with exudative epidermitis, pigs with other lesions and from healthy pigs, and one or more of the toxins could be found among the isolates from the pigs in all the countries. Toxigenic strains of S hyicus were isolated from both healthy and diseased pigs, but the chance of isolating toxigenic strains from pigs with exudative epidermitis was greater than from pigs with other lesions or healthy pigs. Of the 44 isolates from other animal species, only one isolate, from a hare from Belgium, produced ExhB, and one isolate, from a cow with mastitis from Japan, produced ExhA.
Computation of the homotopy of the spectrum tmf

This paper contains a complete computation of the homotopy ring of the spectrum of topological modular forms constructed by Hopkins and Miller. The computation is done away from 6, and at the (interesting) primes 2 and 3 separately, and in each of the latter two cases, a sequence of algebraic Bockstein spectral sequences is used to compute the E2 term of the elliptic Adams‐Novikov spectral sequence from the elliptic curve Hopf algebroid. In a further step, all the differentials in the latter spectral sequence are determined. The result of this computation is originally due to Hopkins and Mahowald (unpublished). 55N34; 55T15
Technical Factors Influencing Cone Packing Density Estimates in Adaptive Optics Flood Illuminated Retinal Images

Purpose To investigate the influence of various technical factors on the variation of cone packing density estimates in adaptive optics flood illuminated retinal images. Methods Adaptive optics images of the photoreceptor mosaic were obtained in fifteen healthy subjects. The cone density and Voronoi diagrams were assessed in sampling windows of 320×320 µm, 160×160 µm and 64×64 µm at 1.5 degree temporal and superior eccentricity from the preferred locus of fixation (PRL). The technical factors that have been analyzed included the sampling window size, the corrected retinal magnification factor (RMFcorr), the conversion from radial to linear distance from the PRL, the displacement between the PRL and foveal center and the manual checking of cone identification algorithm. Bland-Altman analysis was used to assess the agreement between cone density estimated within the different sampling window conditions. Results The cone density declined with decreasing sampling area and data between areas of different size showed low agreement. A high agreement was found between sampling areas of the same size when comparing density calculated with or without using individual RMFcorr. The agreement between cone density measured at radial and linear distances from the PRL and between data referred to the PRL or the foveal center was moderate. The percentage of Voronoi tiles with hexagonal packing arrangement was comparable between sampling areas of different size. The boundary effect, presence of any retinal vessels, and the manual selection of cones missed by the automated identification algorithm were identified as the factors influencing variation of cone packing arrangements in Voronoi diagrams. Conclusions The sampling window size is the main technical factor that influences variation of cone density. Clear identification of each cone in the image and the use of a large buffer zone are necessary to minimize factors influencing variation of Voronoi diagrams of the cone mosaic.
Molecular and Cellular Regulatory Mechanisms of Tongue Myogenesis

The tongue exerts crucial functions in our daily life. However, we know very little about the regulatory mechanisms of mammalian tongue development. In this review, we summarize recent findings of the molecular and cellular mechanisms that control tissue-tissue interactions during tongue morphogenesis. Specifically, cranial neural crest cells (CNCC) lead the initiation of tongue bud formation and contribute to the interstitial connective tissue, which ultimately compartmentalizes tongue muscles and serves as their attachments. Occipital somite-derived cells migrate into the tongue primordium and give rise to muscle cells in the tongue. The intimate relationship between CNCC- and mesoderm-derived cells, as well as growth and transcription factors that have been shown to be crucial for tongue myogenesis, clearly indicate that tissue-tissue interactions play an important role in regulating tongue morphogenesis.
Spatial and Linguistic Aspects of Visual Imagery in Sentence Comprehension

There is mounting evidence that language comprehension involves the activation of mental imagery of the content of utterances (Barsalou, 1999; Bergen, Chang, & Narayan, 2004; Bergen, Narayan, & Feldman, 2003; Narayan, Bergen, & Weinberg, 2004; Richardson, Spivey, McRae, & Barsalou, 2003; Stanfield & Zwaan, 2001; Zwaan, Stanfield, & Yaxley, 2002). This imagery can have motor or perceptual content. Three main questions about the process remain under-explored, however. First, are lexical associations with perception or motion sufficient to yield mental simulation, or is the integration of lexical semantics into larger structures, like sentences, necessary? Second, what linguistic elements (e.g., verbs, nouns, etc.) trigger mental simulations? Third, how detailed are the visual simulations that are performed? A series of behavioral experiments address these questions, using a visual object categorization task to investigate whether up- or down-related language selectively interferes with visual processing in the same part of the visual field (following Richardson et al., 2003). The results demonstrate that either subject nouns or main verbs can trigger visual imagery, but only when used in literal sentences about real space-metaphorical language does not yield significant effects-which implies that it is the comprehension of the sentence as a whole and not simply lexical associations that yields imagery effects. These studies also show that the evoked imagery contains detail as to the part of the visual field where the described scene would take place.
Pneumococcal conjugate vaccines for adults

Pneumococcal polysaccharide vaccines have been recommended for routine use in adults in the US since 1977. The currently approved polysaccharide vaccine (PPV23) contains antigens from 23 of the more than 90 different serotypes of pneumococci. There are conflicting data on its efficacy against invasive infections, but its efficacy against non-bacteremic pneumonia, the most common manifestation of pneumococcal disease in adults, is poor.1–3 Moreover, efficacy of PPV23 declines markedly in persons over the age of 75,2 so older adults, who have both the highest incidence of and the most severe morbidity and mortality from pneumococcal infections, receive the smallest benefit. Therefore, a vaccine that is effective against non-bacteremic pneumonia and is also efficacious in the elderly would be an important advance. Conjugate vaccines might fill this role. Compared with PPV23, the 13-valent pneumococcal conjugate vaccine (PCV13) has superior immunogenicity against some serotypes.3 PCV13 has been approved by the FDA for use in adults. However, the Advisory Committee on Immunization Practices has not yet recommended that PCV13 replace PPV23 for routine use in adults, in part because the incremental benefit of recommending the more expensive PCV13 is unclear. Establishing the efficacy of PCV13 against pneumonia in adults and determining its efficacy in different age and risk groups would help policy makers formulate sound recommendations for use of PCV13.
Key Physiology of Anaerobic Ammonium Oxidation

ABSTRACT The physiology of anaerobic ammonium oxidizing (anammox) aggregates grown in a sequencing batch reactor was investigated quantitatively. The physiological pH and temperature ranges were 6.7 to 8.3 and 20 to 43°C, respectively. The affinity constants for the substrates ammonium and nitrite were each less than 0.1 mg of nitrogen per liter. The anammox process was completely inhibited by nitrite concentrations higher than 0.1 g of nitrogen per liter. Addition of trace amounts of either of the anammox intermediates (1.4 mg of nitrogen per liter of hydrazine or 0.7 mg of nitrogen per liter of hydroxylamine) restored activity completely.
Relationships between Levels of Serum IgE, Cell-Bound IgE, and IgE-Receptors on Peripheral Blood Cells in a Pediatric Population

Background Elevated serum immunoglobulin (Ig) E is a diagnostic marker of immediate-type allergic reactions. We hypothesize that serum IgE does not necessarily reflect total body IgE because in vivo IgE can be bound to cell surface receptors such as FcεRI and FcεRII (CD23). The aim of this study was to analyze the relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. Methodology Whole blood samples from 48 children (26 boys, 22 girls, mean age 10,3±5,4 years) were analyzed by flow cytometry for FcεRI, CD23, and cell-bound IgE on dendritic cells (CD11c+MHC class II+), monocytes (CD14+), basophils (CD123+MHC class II-) and neutrophils (myeloperoxidase+). Total serum IgE was measured by ELISA and converted into z-units to account for age-dependent normal ranges. Correlations were calculated using Spearman rank correlation test. Principal Findings Dendritic cells, monocytes, basophils, and neutrophils expressed the high affinity IgE-receptor FcεRI. Dendritic cells and monocytes also expressed the low affinity receptor CD23. The majority of IgE-receptor positive cells carried IgE on their surface. Expression of both IgE receptors was tightly correlated with cell-bound IgE. In general, cell-bound IgE on FcεRI+ cells correlated well with serum IgE. However, some patients carried high amounts of cell-bound IgE despite low total serum IgE levels. Conclusion/Significance In pediatric patients, levels of age-adjusted serum IgE, cell-bound IgE, and FcεRI correlate. Even in the absence of elevated levels of serum IgE, cell-bound IgE can be detected on peripheral blood cells in a subgroup of patients.
Drink and drug driving: what's the skipper up to?

Objective: Since the introduction of random breath testing (RBT) in Australia there has been a significant reduction in drink driving, as measured by alcohol‐related crashes. In contrast, the prevalence of drug‐related road fatalities is on the increase. One strategy that targets drink‐and/or drug‐driving is the promotion of a designated driver or ‘skipper’. This paper determines to what extent the ‘skipper’ is driving alcohol or drug‐free.
Toxicogenomic and Phenotypic Analyses of Bisphenol-A Early-Life Exposure Toxicity in Zebrafish

Bisphenol-A is an important environmental contaminant due to the increased early-life exposure that may pose significant health-risks to various organisms including humans. This study aimed to use zebrafish as a toxicogenomic model to capture transcriptomic and phenotypic changes for inference of signaling pathways, biological processes, physiological systems and identify potential biomarker genes that are affected by early-life exposure to bisphenol-A. Phenotypic analysis using wild-type zebrafish larvae revealed BPA early-life exposure toxicity caused cardiac edema, cranio-facial abnormality, failure of swimbladder inflation and poor tactile response. Fluorescent imaging analysis using three transgenic lines revealed suppressed neuron branching from the spinal cord, abnormal development of neuromast cells, and suppressed vascularization in the abdominal region. Using knowledge-based data mining algorithms, transcriptome analysis suggests that several signaling pathways involving ephrin receptor, clathrin-mediated endocytosis, synaptic long-term potentiation, axonal guidance, vascular endothelial growth factor, integrin and tight junction were deregulated. Physiological systems with related disorders associated with the nervous, cardiovascular, skeletal-muscular, blood and reproductive systems were implicated, hence corroborated with the phenotypic analysis. Further analysis identified a common set of BPA-targeted genes and revealed a plausible mechanism involving disruption of endocrine-regulated genes and processes in known susceptible tissue-organs. The expression of 28 genes were validated in a separate experiment using quantitative real-time PCR and 6 genes, ncl1, apoeb, mdm1, mycl1b, sp4, U1SNRNPBP homolog, were found to be sensitive and robust biomarkers for BPA early-life exposure toxicity. The susceptibility of sp4 to BPA perturbation suggests its role in altering brain development, function and subsequently behavior observed in laboratory animals exposed to BPA during early life, which is a health-risk concern of early life exposure in humans. The present study further established zebrafish as a model for toxicogenomic inference of early-life chemical exposure toxicity.
REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms

The aim of the present study was to evaluate the effects of the REG Iα and REG Iβ genes on lung cancer cell lines, and thereafter, the expression of REG family genes (REG Iα, REG Iβ, REG III, HIP/PAP and REG IV) in lung cancer in relation to patient prognosis was evaluated. Lung adenocarcinoma (AD) and squamous cell carcinoma (SCC) cell lines expressing REG Iα or REG Iβ (HLC-1 REG Iα/Iβ and EBC-1 REG Iα/Iβ) were established, and cell number, cell invasive activity, and anchorage-independent cell growth were compared with these variables in the control cells. The expression levels of REG family genes were evaluated by real-time RT-PCR in surgically resected lung cancers, and disease-specific survival (DSS) curves were generated. The HLC-1 REG Iα/Iβ cell line showed significant increases in cell number and anchorage-independent cell growth compared with the control cells. EBC-1 REG Iα/Iβ cells showed significant increases in cell invasive activity and anchorage-independent cell growth as compared with the control cells. Except for the REG Iβ gene, expression of other REG family genes was observed in the surgically resected samples; however, DSS was significantly worse only in stage I patients who were positive for REG Iα expression than in patients who were negative for REG Iα expression. The effects of REG Iα on AD and SCC cells were different in the in vitro study, and a correlation between REG Iα expression and patient prognosis was noted in the in vivo study. Therefore, overexpression of REG Iα is a risk factor for poor prognosis caused by discrete mechanisms in AD and SCC patients.