Miracle-dz/UniFAR-FTUs huggingface dataset:
Deep Learning with Kernel Regularization for Visual Recognition

In this paper we aim to train deep neural networks for rapid visual recognition. The task is highly challenging, largely due to the lack of a meaningful regular-izer on the functions realized by the networks. We propose a novel regularization method that takes advantage of kernel methods, where an oracle kernel function represents prior knowledge about the recognition task of interest. We derive an efficient algorithm using stochastic gradient descent, and demonstrate encouraging results on a wide range of recognition tasks, in terms of both accuracy and speed.
THE BEHAVIOR OF THREE DIFFERENT KINDS OF ANTIBODIES IN TUBERCULOSIS: ANTIPROTEIN, ANTIPOLYSACCHARIDE, AND ANTIPHOSPHATIDE

The mode and the level of production of the three different kinds of antibodies, antipolysaccharide, antiprotein, and antiphosphatide, were found to differ considerably with the mode of infection and the virulence of tubercle bacilli. Evidence is given that production of the antipolysaccharide and antiprotein is stimulated without regard to the mode of infection and the virulence of bacilli, while the antiphosphatide is produced chiefly under conditions where in vivo bacilli might have undergone destruction. Of the three antibodies, the level of antiphosphatide was shown to reflect most faithfully the progression of experimental tuberculous infection. The amounts of the three circulating antibodies were found to have no direct relationship to the degree of tuberculin skin hypersensitivity.
Recovery from Open Channel Block by Acetylcholine during Neuromuscular Transmission in Zebrafish

At larval zebrafish neuromuscular junctions (NMJs), miniature end plate currents (mEPCs) recorded in vivo have an unusually fast time course. We used fast-flow application of acetylcholine (ACh) onto outside-out patches to mimic the effect of synaptic release onto small numbers of ACh receptor channels (AChRs). Positively charged ACh acted at hyperpolarized potentials and at millimolar concentrations as a fast (“flickering”) open channel blocker of AChRs. Because of filtering, the open channel block resulted in reduced amplitude of single channel currents. Immediately after brief (1 msec) application (without significant desensitization) of millimolar ACh at hyperpolarized potentials, a slower, transient current appeared because of delayed reversal of the block. This rebound current depended on the ACh concentration and resembled in time course the mEPC. A simple kinetic model of the AChR that includes an open channel-blocking step accounted for our single channel results, as well as the experimentally observed slowing of the time course of mEPCs recorded at a hyperpolarized compared with a depolarized potential. Recovery from AChR block is a novel mechanism of synaptic transmission that may contribute in part at all NMJs.
Species-Specific Differential AhR Expression Protects Human Neural Progenitor Cells against Developmental Neurotoxicity of PAHs

Background Because of their lipophilicity, persistent organic pollutants (POPs) cross the human placenta, possibly affecting central nervous system development. Most POPs are known aryl hydrocarbon receptor (AhR) ligands and activators of AhR signaling. Therefore, AhR activation has been suggested to cause developmental neurotoxicity (DNT). Objective We studied the effects of AhR ligands on basic processes of brain development in two comparative in vitro systems to determine whether AhR-activation is the underlying mechanism for reported DNT of POPs in humans. Methods We employed neurosphere cultures based on human neural progenitor cells (hNPCs) and wild-type and AhR-deficient mouse NPCs (mNPCs) and studied the effects of different AhR agonists [3-methylcholanthrene (3-MC), benzo(a)pyrene [B(a)P], and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)] and an antagonist [3′-methoxy-4′-nitroflavone (MNF)] on neurosphere development. Moreover, we analyzed expression of AhR and genes involved in AhR signaling. Results In contrast to wild-type mNPCs, hNPCs and AhR-deficient mNPCs were insensitive to AhR agonism or antagonism. Although AhR modulation attenuated wild-type mNPC proliferation and migration, hNPCs and AhR-deficient mNPCs remained unaffected. Results also suggest that species-specific differences resulted from nonfunctional AhR signaling in hNPCs. Conclusion Our findings suggest that in contrast to wild-type mNPCs, hNPCs were protected against polycyclic aromatic hydrocarbon–induced DNT because of an absence of AhR. This difference may contribute to species-specific differences in sensitivity to POPs.
Physiological responses of Norway spruce (Picea abies) seedlings to drought stress.

Four-year-old seedlings of Picea abies [L. ] Karst (Norway spruce) were grown in semi-controlled conditions with three watering regimes. The seedlings in the control group (c) were watered to prevent any dehydration effect. The two remaining groups were subjected to mild (ms) and severe water stress (ss), respectively. The following physiological variables were monitored until ss seedlings began to die: leaf water potential (psi(L)), stomatal conductance (g(s)), CO(2) exchange (P(N)), free proline content (Pro), total chlorophyll (a + b) concentration (Chl(t)) and the maximal photochemical efficiency of photosystem II (F(v)/F(m)). The results indicate that not all observed physiological parameters display the same degree of sensitivity to dehydration. After Day 12 of dehydration, psi(L) of ss seedlings was already significantly lower than that of the two other groups. On Day 26, significant differences in psi(L) were recorded among all treatments. Decreasing values of water potential were accompanied by early changes in P(N), g(s) and Pro. A significant decrease in Chl(t) and F(v)/F(m) were only observed during the more advanced stages of dehydration. These results demonstrate that the drought response of P. abies seedlings include a number of parallel physiological and biochemical changes in concert, enhancing the capability of plants to survive and grow during drought periods, but only to a point.
Chemokines and the inflammatory response to viral infection in the central nervous system with a focus on lymphocytic choriomeningitis virus.

Leukocyte migration to the central nervous system (CNS) is a common process with often devastating consequences that follows infection of this tissue compartment with a variety of viruses. The mechanisms underlying this process are poorly defined but, it is hypothesized that chemokines may be important regulatory signals for the cerebral recruitment and extravasation of leukocytes. Here we discuss this hypothesis in the context of different viral infections of the CNS with emphasis on lymphocytic choriomeningitis virus (LCMV). In general, the pattern of chemokine gene expression in these CNS viral infections is dynamic and complex with often overlapping expression of a number of different subclasses of chemokine genes. In the case of CNS infection with LCMV, cerebral chemokine gene expression was observed in euthymic and to a lesser extent athymic mice and preceded increases in cytokine gene expression and in euthymic mice, CNS leukocyte recruitment. These observations together with the finding that CRG-2/IP-10, a prominently expressed chemokine gene in many different CNS viral infections, was expressed by cells intrinsic to the CNS e.g. astrocytes, suggest that activation of chemokine gene expression may be a direct, early and localized host response to viral infection. These findings are consistent with the proposed involvement of chemokines as key signaling molecules for the migration of leukocytes to the CNS following virus infection.
Computational Limits for Matrix Completion

Matrix Completion is the problem of recovering an unknown real-valued low-rank matrix from a subsample of its entries. Important recent results show that the problem can be solved efficiently under the assumption that the unknown matrix is incoherent and the subsample is drawn uniformly at random. Are these assumptions necessary? It is well known that Matrix Completion in its full generality is NP-hard. However, little is known if make additional assumptions such as incoherence and permit the algorithm to output a matrix of slightly higher rank. In this paper we prove that Matrix Completion remains computationally intractable even if the unknown matrix has rank $4$ but we are allowed to output any constant rank matrix, and even if additionally we assume that the unknown matrix is incoherent and are shown $90%$ of the entries. This result relies on the conjectured hardness of the $4$-Coloring problem. We also consider the positive semidefinite Matrix Completion problem. Here we show a similar hardness result under the standard assumption that $\mathrm{P}\ne \mathrm{NP}. $ Our results greatly narrow the gap between existing feasibility results and computational lower bounds. In particular, we believe that our results give the first complexity-theoretic justification for why distributional assumptions are needed beyond the incoherence assumption in order to obtain positive results. On the technical side, we contribute several new ideas on how to encode hard combinatorial problems in low-rank optimization problems. We hope that these techniques will be helpful in further understanding the computational limits of Matrix Completion and related problems.
Quantitation of Gene Expression by Real-Time PCR Disproves a “Retroviral Hypothesis” for Childhood-Onset Diabetes Mellitus

Children with insulin-dependent diabetes mellitus (IDDM) suffer from a chronic autoimmune β cell destruction of unknown origin, maybe due to superantigens or retroviral endogenous genes. Recently, a novel endogenous retrovirus designated as IDDMK1,222 was proposed to encode for such a candidate autoimmune gene in type 1 diabetes. We therefore analyzed the expression of IDDMK1,222 genes in peripheral blood leukocytes and plasma from 55 healthy children and 55 diabetic children including 11 patients with acute disease onset. In our study we applied an improved quantitative and highly specific real-time PCR assay. In contrast to previous data obtained by conventional PCR, IDDMK1,222 gene expression did not differ between diabetic and nondiabetic individuals. For this reason, we propose that IDDMK1,222 is an ubiquitous endogenous retroviral element in the human genome but not a candidate autoimmune gene for IDDM, especially in childhood-onset disease. Real-time PCR proved to be a highly sensitive and specific method for detection and quantitation of very low amounts of mRNA and will thereby be useful regarding the special demands in pediatric studies dealing with very low amounts of specimen.
Multi-frequency measurements of the NVSS foreground sources in the cosmic background imager fields - I. Data release

Context. We present the results of the flux density measurements at 4.85 GHz and 10.45 GHz of a sample of 5998 NVSS radio sources with the Effelsberg 100 m telescope. Aims. The initial motivation was the need to identify the NVSS radio sources that could potentially contribute significant contaminating flux in the frequency range at which the Cosmic Background Imager experiment operated. Methods. An efficient way to achieve this challenging goal has been to compute the high frequency flux density of those sources by extrapolating their radio spectrum. This is determined by the three-point spectral index measured on the basis of the NVSS entry at 1.4 GHz and the measurements at 4.85 GHz and 10.45 GHz carried out with the 100 m Effelsberg telescope. Results. These measurements are important since the targeted sample probes the weak part of the flux density distribution, hence the decision to make the data available. Conclusions. We present the table with flux density measurements of 3434 sources that showed no confusion allowing reliable measurements, their detection rates, their spectral index distribution and an interpretation which explains satisfactorily the observed uncertainties.
Race, Redistricting, and Representation

This Essay, which was written for the Ohio State Law Journal's symposium on Election Law and the Roberts Court, examines the Court's decision in League of United Latin American Citizens (LULAC) v. Perry. The Essay explores two ways of reading LULAC: first as a racial representation case and second as a case concerned with representation itself. The essay argues that politics not race is the majority's worry in LULAC and that the case is the first application of Justice Kennedy's representation rights concept first introduced in Vieth.
Remote ischemic preconditioning in patients with intermittent claudication

OBJECTIVE: Remote ischemic preconditioning (RIPC) is a phenomenon in which a short period of sub-lethal ischemia in one organ protects against subsequent bouts of ischemia in another organ. We hypothesized that RIPC in patients with intermittent claudication would increase muscle tissue resistance to ischemia, thereby resulting in an increased ability to walk. METHODS: In a claudication clinic, 52 ambulatory patients who presented with complaints of intermittent claudication in the lower limbs associated with an absent or reduced arterial pulse in the symptomatic limb and/or an ankle-brachial index <0.90 were recruited for this study. The patients were randomly divided into three groups (A, B and C). All of the patients underwent two tests on a treadmill according to the Gardener protocol. Group A was tested first without RIPC. Group A was subjected to RIPC prior to the second treadmill test. Group B was subjected to RIPC prior to the first treadmill test and then was subjected to a treadmill test without RIPC. In Group C (control group), both treadmill tests were performed without RIPC. The first and second tests were conducted seven days apart. Brazilian Clinical Trials: RBR-7TF6TM. RESULTS: Group A showed a significant increase in the initial claudication distance in the second test compared to the first test. CONCLUSION: RIPC increased the initial claudication distance in patients with intermittent claudication; however, RIPC did not affect the total walking distance of the patients.
Real-Life Clinical Use of Symbicort® Maintenance and Reliever Therapy for Asthmatic Patients in Korea

The aim of this study was to examine the daily practice patterns of Symbicort® Maintenance and Reliever Therapy (SMART) in Korean asthmatic patients and to analyze clinical signs related to overuse. This study used an observational, multicenter, noninterventional, prospective, uncontrolled design for examining asthmatic patients prescribed SMART to assess the frequency and pattern of Symbicort® usage as a maintenance and reliever medication. The characteristics of patients showing signs of overuse (frequency of inhalation: 8 or more times per day) were also analyzed. Among the 1,518 patients analyzed, 1,292 (85.1%) completed the trial. The number of mean inhalations per day was 2.14±1.15; the number of patients who had at least 1 as needed usage (PRN) inhalation per day was 843 (55.5%); the mean frequency of PRN use was 0.25±0.67 inhalations per day. The number of patients who overused for at least 1 day was 260 (17.1%). In particular, young patients, patients with limited physical activity, and patients with nocturnal symptoms demonstrated high frequency of overuse. The frequency of overuse during SMART was not high in Korean asthmatic patients and the asthma status of follow-up outpatients improved overall. However, there is a need for careful education targeted toward younger patients, patients with limited physical activity, and patients with nocturnal symptoms owing to their tendency to frequently overuse.
The Effects of Governmental Protected Areas and Social Initiatives for Land Protection on the Conservation of Mexican Amphibians

Traditionally, biodiversity conservation gap analyses have been focused on governmental protected areas (PAs). However, an increasing number of social initiatives in conservation (SICs) are promoting a new perspective for analysis. SICs include all of the efforts that society implements to conserve biodiversity, such as land protection, from private reserves to community zoning plans some of which have generated community-protected areas. This is the first attempt to analyze the status of conservation in Latin America when some of these social initiatives are included. The analyses were focused on amphibians because they are one of the most threatened groups worldwide. Mexico is not an exception, where more than 60% of its amphibians are endemic. We used a niche model approach to map the potential and real geographical distribution (extracting the transformed areas) of the endemic amphibians. Based on remnant distribution, all the species have suffered some degree of loss, but 36 species have lost more than 50% of their potential distribution. For 50 micro-endemic species we could not model their potential distribution range due to the small number of records per species, therefore the analyses were performed using these records directly. We then evaluated the efficiency of the existing set of governmental protected areas and established the contribution of social initiatives (private and community) for land protection for amphibian conservation. We found that most of the species have some proportion of their potential ecological niche distribution protected, but 20% are not protected at all within governmental PAs. 73% of endemic and 26% of micro-endemic amphibians are represented within SICs. However, 30 micro-endemic species are not represented within either governmental PAs or SICs. This study shows how the role of land conservation through social initiatives is therefore becoming a crucial element for an important number of species not protected by governmental PAs.
IoT data privacy via blockchains and IPFS

Blockchain, the underlying technology of cryptocurrency networks like Bitcoin, can prove to be essential towards realizing the vision of a decentralized, secure, and open Internet of Things (IoT) revolution. There is a growing interest in many research groups towards leveraging blockchains to provide IoT data privacy without the need for a centralized data access model. This paper aims to propose a decentralized access model for IoT data, using a network architecture that we call a modular consortium architecture for IoT and blockchains. The proposed architecture facilitates IoT communications on top of a software stack of blockchains and peer-to-peer data storage mechanisms. The architecture is aimed to have privacy built into it, and to be adaptable for various IoT use cases. To understand the feasibility and deployment considerations for implementing the proposed architecture, we conduct performance analysis of existing blockchain development platforms, Ethereum and Monax.
Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.

UNLABELLED Somatic mutations in the EGFR kinase domain drive lung adenocarcinoma. We have previously identified MIG6, an inhibitor of ERBB signaling and a potential tumor suppressor, as a target for phosphorylation by mutant EGFRs. Here, we demonstrate that MIG6 is a tumor suppressor for the initiation and progression of mutant EGFR-driven lung adenocarcinoma in mouse models. Mutant EGFR-induced lung tumor formation was accelerated in Mig6-deficient mice, even with Mig6 haploinsufficiency. We demonstrate that constitutive phosphorylation of MIG6 at Y394/Y395 in EGFR-mutant human lung adenocarcinoma cell lines is associated with an increased interaction of MIG6 with mutant EGFR, which may stabilize EGFR protein. MIG6 also fails to promote mutant EGFR degradation. We propose a model whereby increased tyrosine phosphorylation of MIG6 decreases its capacity to inhibit mutant EGFR. Nonetheless, the residual inhibition is sufficient for MIG6 to delay mutant EGFR-driven tumor initiation and progression in mouse models. SIGNIFICANCE This study demonstrates that MIG6 is a potent tumor suppressor for mutant EGFR-driven lung tumor initiation and progression in mice and provides a possible mechanism by which mutant EGFR can partially circumvent this tumor suppressor in human lung adenocarcinoma.
Nonlinear optimal control synthesis via occupation measures

We consider nonlinear optimal control problems (OCPs) for which all problem data are polynomial. In the first part of the paper, we review how occupation measures can be used to approximate pointwise the optimal value function of a given OCP, using a hierarchy of linear matrix inequality (LMI) relaxations. In the second part, we extend the methodology to approximate the optimal value function on a given set and we use such a function to constructively and computationally derive an almost optimal control law. Numerical examples show the effectiveness of the approach.
Federal Reserve Bank of San Francisco Should Transportation Spending Be Included in a Stimulus Program? a Review of the Literature Should Transportation Spending Be Included in a Stimulus Program? a Review of the Literature

The views in this paper are solely the responsibility of the authors and should not be interpreted as reflecting the views of the Federal Reserve Bank of San Francisco or the Board of Governors of the Federal Reserve System. Transportation spending often plays a prominent role in government efforts to stimulate the economy during downturns. Yet, despite the frequent use of transportation spending as a form of fiscal stimulus, there is little known about its short-or medium-run effectiveness. Does it translate quickly into higher employment and economic activity or does it impact the economy only slowly over time? This paper reviews the empirical findings in the literature for the United States and other developed economies and compares the effects of transportation spending to those of other types of government spending.
Impact of Schmallenberg virus on British sheep farms during the 2011/2012 lambing season

British sheep farmers were invited to complete a questionnaire about the impact of Schmallenberg virus (SBV) on animal health, welfare and their own emotional wellbeing during the 2011–2012 lambing season, through Defra and Farming Industry websites, letters to farmers who had requested SBV laboratory tests and advertisement at Sheep 2012. The 494 responders included SBV confirmed (positive by RT-PCR) (n=76), SBV suspected by farmer (n=140) or SBV not suspected (n=278). Percentage of barren ewes was similar across SBV groups, however, lamb and ewe losses were higher on responder farms where SBV was confirmed or suspected. The median percentages of all lambs born (and lambs born deformed ) that died within one week of birth was 10.4 per cent (5.5 per cent), 7.0 per cent (2.9 per cent) and 5.3 per cent (0 per cent), respectively, on SBV confirmed, suspected and not suspected farms (P<0.001). Eight to 16 per cent of SBV confirmed or suspected farms reported lamb mortality of ≥40 per cent. Farmer perceived impact was greater where SBV was confirmed or suspected (P<0.001): 25 per cent reported a high impact on emotional wellbeing (4 per cent of SBV not suspected), 13 per cent reported a high impact on flock welfare and financial performance and 6 per cent were less likely to farm sheep next year because of SBV (<2 per cent in SBV not suspected). Overall, SBV impact has been large relative to reported sheep loss.
New Techniques for SET Sensitivity and Propagation Measurement in Flash-Based FPGAs

Single-event transients (SETs) remain a concern in field-programmable gate arrays (FPGAs) used for space applications. However, accurate measurement of SETs in FPGAs is challenging. This paper describes a calibrated circuit for on-chip measurement of SETs with a temporal precision better than one gate delay. In addition, a technique to measure the final effect of SETs in clocked, complex circuits is presented. Heavy-ion test results for a ProASIC3L FPGA are reported, highlighting a strong dependence between the VersaTile configuration and input signal state with the SET sensitivity and pulse propagation.