Miracle-dz/UniFAR-FTUs huggingface dataset:
Does Participation in Physical Education Reduce Sedentary Behaviour in School and throughout the Day among Normal-Weight and Overweight-to-Obese Czech Children Aged 9–11 Years?

Participation of 9 to 11-year-old children in physical education lessons (PEL) contributes to a significantly higher duration of moderate-to-vigorous physical activity (MVPA) during the school day and, in overweight/obese girls and normal-weight boys, to an increase in overall daily MVPA as shown by previous research. However, it is not known whether this increase in MVPA is at the expense of light physical activity (LPA) or sedentary behaviour (SED). SED, LPA, and MVPA were assessed in 338 schoolchildren aged 9–11 years (50.3% girls; 29.6% overweight/obese) over two school days (with and without a PEL) using a triaxial accelerometer during various segments of the school day. SED, LPA, and MVPA were quantified based on the duration of the activity (minutes). Participation in PEL led to significantly higher school MVPA in the overweight/obese and normal-weight girls and boys (p < 0.005) compared to MVPA of those children on the school day without PEL. Participation in PEL led to a significantly higher overall daily MVPA duration compared to that during the day without PEL for the overweight/obese girls (p < 0.05), normal-weight girls (p < 0.05) and boys (p < 0.005). Participation in PEL contributed not only to significantly higher LPA in the normal-weight girls and boys (p < 0.01) during the school day but also reduced school-time SED in the overweight/obese children (p < 0.01) and normal-weight girls (p < 0.005). Moreover, participation in PEL significantly reduced the overall daily SED in the normal-weight children and overweight/obese boys (p < 0.05). Adding one PEL to the daily school routine appears to be a promising strategy for effectively reducing SED in children.
What Keeps Early Childhood Teachers Working in Long Day Care?

RETAINING EARLY CHILDHOOD TEACHERS in long day care (LDC) is a pressing challenge for Australia's reform agenda in early childhood education and care (ECEC). Case study research with five early childhood teachers in LDC revealed individual and contextual factors that enabled and challenged the teachers to stay in LDC. Drawing on social constructivist approaches, the research contributes empirically based insights that support the recruitment and retention of early childhood teachers in LDC.
Hypertonic Saline Resuscitation Modulates Neutrophil Adhesion Molecule Expression of Post-Traumatic Hemorrhagic Shock Patients

Abstract : Fluid resuscitation for traumatic hemorrhagic shock remains controversial since current protocols using large-volume crystalloid may exacerbate post-traumatic inflammation and organ dysfunction. Experimental data suggests that hypertonic saline/dextran (HSD, 7.5% NaCl in 6% dextran-70) exerts antiinflammatory and immunomodulatory effects, reduces multiorgan dysfunction and improves outcome. First trial examining the immunomodulatory properties of HSD in humans. Based on experimental findings, this study proposes to determine whether a single bolus of HSD might modulate the inflammatory response to hemorrhagic shock. Randomized, double-blinded, placebo-controlled clinical trial. Patients - 27 adult patients, victims of blunt trauma and hypotension due to hemorrhage. 13 patients received HSD, 2 excluded for failing inclusion criteria and 1 for refusing participation. Upon arrival, eligible patients received a single 250-ml bolus of either HSD or placebo (0.9% NaCl) from unmarked bags. Blood samples were collected prior to infusion and over subsequent 24 hours. All patients underwent standard resuscitation. HSD markedly altered shock-induced changes in key adhesion molecules on circulating neutrophils compared to placebo. HSD abolished shock-induced upregulation of CD11b and caused extensive CD62L shedding. Leukocyte counts were similar, except for lymphocytes where HSD prevented the lymphopenia detected in the control group. HSD patients required less crystalloid and blood during the first 24 hours. HSD patients were liberated from mechanical ventilation 24 hours earlier than control. ICU stay, organ dysfunction, infections and mortality did not differ between groups. HSD modestly increased serum sodium and osmolarity. No complications were associated to HSD.
Literature review: health-related quality of life measurement in pediatric oncology: hearing the voices of the children.

OBJECTIVES The objective of this literature review is to provide an overview of the evidence for pediatric patient self-report in pediatric oncology. Methods A review of the general literature on pediatric health-related quality of life (HRQOL) measurement as background, with pediatric patient self-report data from the Journal of Pediatric Psychology during the past 5 years in pediatric oncology summarized. Utilizing the PedsQL available at (http://www.pedsql.org), data are presented to illustrate child and parent reports in pediatric oncology. Results Data demonstrate that children as young as 5 years of age can reliably and validly self-report their HRQOL when an age-appropriate instrument is utilized. Conclusions The evidence supports including pediatric patients' perspectives in clinical trials. Parent proxy-report is recommended when pediatric patients are too young, too cognitively impaired, too ill or fatigued to complete a HRQOL instrument, but not as a substitute for child self-report when the child is willing and able to provide their perspective.
Role of Radiation Therapy in Adult Extraskeletal Ewing's Sarcoma Patients Treated with Chemotherapy and Surgery

Radiation therapy (RT) is advocated in the multimodal treatment of high-grade soft tissue sarcoma (STS), but its role may be less clear in chemotherapy-sensitive STS such as extraskeletal Ewing sarcoma (EES). The purpose of this study was to determine the role of RT on overall survival (OS) in localized EES adult patients treated with chemotherapy and surgery. Adult patients diagnosed with EES and reported to the National Cancer Database from 2004 to 2014 were evaluated. All patients were treated with surgical resection. Patient demographics, tumor characteristics, treatments received, resection margins, and survival were examined for the 232 patients identified. Using multivariate analysis and Cox proportional hazard analysis, predictors of OS were determined. In the overall cohort, 40 percent of patients received RT and 78 percent received chemotherapy, with 31 percent receiving both. The addition of RT to the patients receiving surgery + chemotherapy did not improve OS (p < 0.05). Twenty-four percent of patients who achieved R0 resection after surgery still received RT without any improvement in OS. Patients treated at community cancer centers were more likely to receive additional RT compared with Comprehensive Cancer Centers (p < 0.05). In adult EES patients with localized disease treated with chemotherapy and surgery, the addition of RT does not improve overall survival.
Inactivation of Rho Signaling Pathway Promotes CNS Axon Regeneration

Regeneration in the CNS is blocked by many different growth inhibitory proteins. To foster regeneration, we have investigated a strategy to block the neuronal response to growth inhibitory signals. Here, we report that injured axons regrow directly on complex inhibitory substrates when Rho GTPase is inactivated. Treatment of PC12 cells with C3 enzyme to inactivate Rho and transfection with dominant negative Rho allowed neurite growth on inhibitory substrates. Primary retinal neurons treated with C3 extended neurites on myelin-associated glycoprotein and myelin substrates. To explore regeneration in vivo, we crushed optic nerves of adult rat. After C3 treatment, numerous cut axons traversed the lesion to regrow in the distal white matter of the optic nerve. These results indicate that targeting signaling mechanisms converging to Rho stimulates axon regeneration on inhibitory CNS substrates.
Abbott AxSYM random and continuous access immunoassay system for improved workflow in the clinical laboratory.

We describe a new clinical laboratory instrument, the Abbott AxSYM, which provides random- and continuous-access testing for immunoassays, 20 onboard reagents, primary tube sampling, and a throughput of 80 to 120 tests per hour. The AxSYM incorporates three separate analytical technologies for processing immunoassays: microparticle enzyme immunoassay, fluorescence polarization immunoassay, and a novel technology known as ion-capture immunoassay. The system incorporates both common and technology-specific subsystems controlled by a real-time software scheduling processor. Tests can be processed in one- or two-step sandwich or competitive formats, with variable pipetting steps, incubation periods, optical read formats, and wash sequences. Menu capabilities include tests for hepatitis, retrovirus, tumor markers, fertility markers, thyroid functions, and therapeutic drugs. The time to first result is approximately 15-25 min for most routine assays and < or = 15 min for stat assays (i.e., creatine kinase MB isoenzyme, human chorionic gonadotropin beta subunit, and therapeutic drugs). AxSYM assay performance for 23 assays was comparable with that of the Abbott IMx and TDx analyzers; specimen correlation data had correlation coefficients ranging from 0.97 to 0.99 and slopes ranging from 0.99 to 1.10. Within-run imprecision (CV) was 1.5% to 11.4%, with most assays (19 of 23) demonstrating CVs < or = 8.0%.
Biomass burning related ozone damage on vegetation over the Amazon forest: a model sensitivity study

Abstract. The HadGEM2 earth system climate model was used to assess the impact of biomass burning on surface ozone concentrations over the Amazon forest and its impact on vegetation, under present-day climate conditions. Here we consider biomass burning emissions from wildfires, deforestation fires, agricultural forest burning, and residential and commercial combustion. Simulated surface ozone concentration is evaluated against observations taken at two sites in the Brazilian Amazon forest for years 2010 to 2012. The model is able to reproduce the observed diurnal cycle of surface ozone mixing ratio at the two sites, but overestimates the magnitude of the monthly averaged hourly measurements by 5–15 ppb for each available month at one of the sites. We vary biomass burning emissions over South America by ±20, 40, 60, 80 and 100% to quantify the modelled impact of biomass burning on surface ozone concentrations and ozone damage on vegetation productivity over the Amazon forest. We used the ozone damage scheme in the "high" sensitivity mode to give an upper limit for this effect. Decreasing South American biomass burning emissions by 100% (i.e. to zero) reduces surface ozone concentrations (by about 15 ppb during the biomass burning season) and suggests a 15% increase in monthly mean net primary productivity averaged over the Amazon forest, with local increases up to 60%. The simulated impact of ozone damage from present-day biomass burning on vegetation productivity is about 230 TgC yr−1. Taking into account that uncertainty in these estimates is substantial, this ozone damage impact over the Amazon forest is of the same order of magnitude as the release of carbon dioxide due to fire in South America; in effect it potentially doubles the impact of biomass burning on the carbon cycle.
An Investigation of Abstract Construal on Impression Formation: A Multi-Lab Replication of McCarthy and Skowronski (2011)

Perceivers often view individuals described as “warm” to be generally positive and individuals described as “cold” to be generally negative. Consistent with the tenets of Construal Level Theory, McCarthy and Skowronski (2011) demonstrated this difference was larger among perceivers who were instructed the information was psychologically distant rather than psychologically near; however, those results have never been subjected to replication attempts. To test the replicability of those results, we closely replicated the methods of McCarthy and Skowronski (2011) Study 1b at eight separate data collection sites and pooled the results into a random-effects meta-analysis. Within the replication attempts, the overall effect was not significantly different from zero (d = 0.10, 95% CI [–0.01, 0.22]) and an equivalence test confirmed this effect was smaller than our smallest effect size of interest. However, when the original study was incorporated into the meta-analysis, the overall effect was significantly different from zero in the theoretically-consistent direction (d = 0.13, 95% CI [0.02, 0.24]). The weight of the overall evidence suggests the traits “warm” and “cold” are more influential among participants who were presented with information that was psychologically distant; however, this effect is small. Future research should try to identify more potent moderators, which would make the effect more affordable to detect.
Nascent Doubts May Presage Conceptual Clarity: Reply to Surbey

It is difficult for anyone to acknowledge that an idea he or she has been leaching may be invalid. I faced this situation several years ago and, after a period of vacillation, concluded that heritability analysis, the dominant paradigm in behavioural genetics, was not merely weak at its foundations but actively misleading to the nonspecialist; hence, it ought to be relegated to the history of science along with phlogiston, penis envy and cold fusion. During a postdoctoral fellowship year with McClearn and DeFries at the Institute for Behavioral Genetics at the University of Colorado in 1968-69, I eagerly absorbed the lessons of Falconer and my mentors, who were foremost authorities on heritability analysis. These lessons were acquired easily because mathematically they were so similar to the classic rendition of the analysis of variance presented by Hays and Winer, the stans6cal gurus of psychology graduate students in that period.
8-hydroxy-2'-deoxyguanosine, a major mutagenic oxidative DNA lesion, and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution.

Southwest metropolitan Mexico City children are repeatedly exposed to high levels of a complex mixture of air pollutants, including ozone, particulate matter, aldehydes, metals, and nitrogen oxides. We explored nasal cell 8-hydroxy-2'-deoxyguanosine (8-OHdG), a major mutagenic lesion producing G-->T transversion mutations, using an immunohistochemical method, and DNA single strand breaks (ssb) using the single cell gel electrophoresis assay as biomarkers of oxidant exposure. Nasal biopsies from the posterior inferior turbinate were examined in children in grades one through five, including 12 controls from a low-polluted coastal town and 87 Mexico City children. Each biopsy was divided for the 8-OHdG and DNA ssb assays. There was an age-dependent increase in the percentage of nasal cells with DNA tails > 10 microm in Mexico City children: 19 +/- 9% for control cells, and 43 +/- 4, 50 +/- 16, 56 +/- 17, 60 +/- 17 and 73 +/- 14%, respectively, for first through fifth graders (p < 0.05). Nasal ssb were significantly higher in fifth graders than in first graders (p < 0.05). Higher levels (2.3- to 3-fold) of specific nuclear staining for 8-OHdG were observed in exposed children as compared to controls (p < 0.05). These results suggest that DNA damage is present in nasal epithelial cells in Mexico City children. Persistent oxidative DNA damage may ultimately result in a selective growth of pr eneoplastic nasal initiated cells in this population and the potential for nasal neoplasms may increase with age. The combination of 8-OHdG and DNA ssb should be useful for monitoring oxidative damage in people exposed to polluted atmospheres. ImagesFigure 1Figure 2Figure 3Figure 4
The Analytic Hierarchy Process and the Theory of Measurement

The analytic hierarchy process (AHP) is a decision-making procedure widely used in management for establishing priorities in multicriteria decision problems. Underlying the AHP is the theory of ratio-scale measures developed in psychophysics since the middle of the last century. It is, however, well known that classical ratio-scaling approaches have several problems. We reconsider the AHP in the light of the modern theory of measurement based on the so-called separable representations recently axiomatized in mathematical psychology. We provide various theoretical and empirical results on the extent to which the AHP can be considered a reliable decision-making procedure in terms of the modern theory of subjective measurement.
Comparative Genomics Reveals New Candidate Genes Involved in Selenium Metabolism in Prokaryotes

Selenium (Se) is an important micronutrient that mainly occurs in proteins in the form of selenocysteine and in tRNAs in the form of selenouridine. In the past 20 years, several genes involved in Se utilization have been characterized in both prokaryotes and eukaryotes. However, Se homeostasis and the associated regulatory network are not fully understood. In this study, we conducted comparative genomics and phylogenetic analyses to examine the occurrence of all known Se utilization traits in prokaryotes. Our results revealed a highly mosaic pattern of species that use Se (in different forms) in spite that most organisms do not use this element. Further investigation of genomic context of known Se-related genes in different organisms suggested novel candidate genes that may participate in Se metabolism in bacteria and/or archaea. Among them, a membrane protein, YedE, which contains ten transmembrane domains and shows distant similarity to a sulfur transporter, is exclusively found in Se-utilizing organisms, suggesting that it may be involved in Se transport. A LysR-like transcription factor subfamily might be important for the regulation of Sec biosynthesis and/or other Se-related genes. In addition, a small protein family DUF3343 is widespread in Se-utilizing organisms, which probably serves as an important chaperone for Se trafficking within the cells. Finally, we proposed a simple model of Se homeostasis based on our findings. Our study reveals new candidate genes involved in Se metabolism in prokaryotes and should be useful for a further understanding of the complex metabolism and the roles of Se in biology.
Orthomodular lattices, Foulis Semigroups and Dagger Kernel Categories

This paper is a sequel to arXiv:0902.2355 and continues the study of quantum logic via dagger kernel categories. It develops the relation between these categories and both orthomodular lattices and Foulis semigroups. The relation between the latter two notions has been uncovered in the 1960s. The current categorical perspective gives a broader context and reconstructs this relationship between orthomodular lattices and Foulis semigroups as special instance.
Carcinogen-DNA Adduct Formation in the Lungs and Livers of Preweanling CD-I Male Mice following Administration of [ 3 H ]-6-Nitrochrysene , [ 3 H ]-6-Aminochrysene , and [ 3 H ]-l , 6 -

6-Nitrochrysene (NC) and 6-aminochrysene (AC) have been shown to be potent lung and liver carcinogens when administered in multiple i.p. doses to preweanling mice. 1,6-Dinitropyrene has been shown to be a strong hepatocarcinogen but a weak lung carcinogen in this same bioassay. We have examined carcinogen-DNA adduct profiles in the target tissues of preweanling male CD-I mice following administration of single or multiple doses of these compounds. Depending on the tissue and the dosing schedule, the total level of DNA modification in animals dosed with | 'I I|N( was 2to 9-fold higher than in animals dosed with |'I I|A( . Regardless of the dosing schedule, DNA isolated from the lungs and livers of both |3H|NCand [3H|AC-treated preweanling male mice con tained a single major and chromatographically identical adduct. This major adduct, which accounted for as much as 90% of the total carcino gen-DNA adduces in enzymatic hydrolysates from treated animals, was chromatographically distinct from the major C8-purine-substituted adducts formed from the reaction of N-hydroxy-AC with calf thymus DNA. In contrast to the results obtained with NC and AC, the major carcinogenDNA adduct formed in the livers of mice treated with [3H|-l,6-dinitropyrene was found to cochromatograph with l-AKdeoxyguanosin-8yl)animo-6-mtrr.pyrene, a product derived from /V-hydro\y-l-amino-6nitropyrene. Since NC and its nitro-reduced derivative, AC, yielded an identical carcinogen-DNA adduct in vivo and this adduct was not derived from V hydroxy-AC, we conclude that the metabolic activation of NC in the neonatal mouse must involve some previously undescribed combination of ring-oxidation and nitro-reduction pathways. This activation pathway could be an important factor in determining the potency of NC and AC as carcinogens in this bioassay system.
Growth in demand and supply of pulses in India-A normative approach

The changing scenario of consumption and production of pulses will have significant influence on the demand- supply prospects of pulses in India. The country as whole, production of redgram had increased marginally (0.45%) during 1980-2012(Overall study period), though there is positive and significant growth in production(2.86%) during 1980-90 (Period-I), mainly due to lower growth during 1991-2012(period-II). The significant growth in production (1.39%) and productivity (1.04%) of bengalgram in the entire period except area (0.35%) was observed. However, growth in greengram production (1.14%) and productivity (1.21%) was found almost similar. In case of blackgram, positive growth rate in area, productivity and production in both the periods have ultimately resulted higher growth rates in the overall period. The growth in total pulses production indicated that growth in area (-0.10%) was negative while it was positive both in production (1.49%) and productivity (1.59%) during period-I. Similar pattern of growth was observed during period-II and in the overall study period. The estimated demand for pulses were 183.62 lakh tonnes over supply of 148.66 lakh tonnes indicating deficit of 34.96 lakh tonnes during 2001 â€“2011. Further, demand for pulses expected to reach 225.36 and 255.16 lakh tonnes in the year 2020 and 2030 respectively. Whereas, supply of pulses will reach 218.50 and 237.00 lakh tonnes in the same period indicating narrow gap between demand and supply in the future.
Integrable Renormalization I : the Ladder Case

In recent years a Hopf algebraic structure underlying the process of renormalization in quantum field theory was found. It led to a Birkhoff factorization for (regularized) Hopf algebra characters, i.e. for Feynman rules. In this work we would like to show that this Birkhoff factorization finds its natural formulation in terms of a classical r-matrix, coming from a Rota-Baxter structure underlying the target space of the regularized Hopf algebra characters. Working in the rooted tree Hopf algebra, the simple case of the Hopf subalgebra of ladder trees is treated in detail. The extension to the general case, i.e. the full Hopf algebra of rooted trees or Feynman graphs is briefly outlined. kurusch@ihes.fr liguo@newark.rutgers. edu kreimer@ihes.fr and dkreimer@bu.edu. Center for Math. Phys., Boston University.
Attitudes to Ethnic Minorities, Ethnic Context and Location Decisions

The attitudes of ethnic majority populations towards other communities is a potentially important determinant of social exclusion and of the welfare of ethnic minorities. The suggestion that negative attitudes towards minorities may be affected by the ethnic composition of the locality in which individuals live has often been made and empirically investigated. We point to an important potential for bias in simple estimates of ethnic context effects if individual location decisions are driven in part by attitudinal factors. We also suggest an instrumental variables procedure for overcoming such bias in data with appropriate spatial information. Our results suggest that allowing for such effects is of considerable importance.