Miracle-dz/UniFAR-FTUs huggingface dataset:
Anesthesiology Pain Medicine Kowsar Comparison between Effect of Lidocaine, Morphine and Ketamine Spray on Post-tonsillectomy Pain in Children a R T I C L E I N F O a B S T R a C T

Implication for health policy/practice/research/medical education: This study brings important light in the field of pediatric post-tonsillectomy analgesia for anesthesiologists, because they could have a great impact on managing pain in pediatric tonsillectomy surgery. Pain is an unpleasant sensory and emotional experiences associated with actual or potential tissue damage (1, 2). Undergoing treatment may result in the occurrence of post-operative pain and this triggers biochemical and physiological stress responses. It also causes impair-Background: An effective pain therapy to block or modify the physiological responses to stress has become an essential component of modern pediatric anesthesia and surgical practice. Objectives: The goal of this study was to compare the analgesic effects of the spray forms of; lidocaine, morphine, ketamine, and normal saline on post-tonsillectomy pain scores in children. Patients and Methods: A total of 120 children, American Society of Anesthesiologist (ASA) class I-II, scheduled for elective tonsillectomy were enrolled in this double-blind, clinical trial study. They were randomly divided into 4 groups, each receiving one of the following drugs at the end of operation; lidocaine spray (2 mg/kg); morphine spray (0.05 mg/kg); ketamine spray (0.5 mg/kg); or normal saline spray (8 puffs). For comparison of postoperative pain; the face, legs, activity, cry, consolability (FLACC) pain scale was evaluated during the first one hour of recovery period at 20 minutes intervals. The data was transferred to SPSS-10 software and analyzed statistically with the Scheffe test and Dun-nett's T3 test. P value less than 0.05 was considered significant. Results: In the early postoperative period (time: 0) and at 20, 40 and 60 minutes of recovery time, FLACC scale scores in the control group were higher than in the three other groups. At 20 minutes, the FLACC scale score in the lidocaine group was lower than in the other groups. At 40 minutes, the statistical differences between FLACC scales of the lidocaine, morphine and ketamine groups were not significant (P > 0.05). Finally, at 60 minutes, the FLACC scale scores of the ketamine and morphine groups were lower than in the other groups. Conclusions: The results of this study showed that lidocaine spray had the best pain controlling effect at 20 minutes in the recovery room, but after 40 minutes, ketamine and morphine sprays were more effective than the lidocaine spray.
Influence of fabrication process on the final properties of natural-rubber latex tubes for vascular prosthesis

We report a process of fabrication of latex tubes using the dip-coating technique. We investigated centrifuged latex, with different original viscosities, extracted from the Hevea brasiliensis. The influence of the main deposition parameters (dip-coating velocity, mold material, mold diameter and number of coatings) and post-deposition drying process parameters (temperature and time) on the properties of the final samples are investigated and discussed. Additional investigation about the elastic behavior of the tubes is presented for strain values up to rupture. The rupture occurred at 120 mm for tubes 15 mm-long, which represents an elongation of 800%. The tubes presented two distinct elastic mechanisms, with the most elastic one being observed below an elongation of about 500%. During a cycled strain experiment with strain values below the rupture point, a hysteretic-like curve was observed, which was related to the uncurling and recurling of the polymeric chains.
Collaboration in Global Software Projects at Siemens: An Experience Report

As a globally operating company with about 30,000 software engineers worldwide, Siemens has accumulated a wide variety of experiences in global development. Many individuals and organizations have adjusted their practices to deal with the challenges related to the geographic distribution of the development effort. From a corporate perspective, Siemens has accumulated a rich base of knowledge about global development and how to approach it successfully. The Siemens software initiative - a company-wide improvement program for software development at Siemens - has worked on collecting this widely-distributed knowledge and synthesizing it in a form accessible to the wider software development community. In this paper, the approach as well as key learnings in people and communication-related aspects of collaboration are summarized.
TEACHER CLASSROOM PRACTICES AND STUDENT PERFORMANCE: HOW SCHOOLS CAN MAKE A DIFFERENCE

Quantitative studies of school effects have generally supported the notion that the problems of U.S. education lie outside of the school. Yet such studies neglect the primary venue through which students learn, the classroom. The current study explores the link between classroom practices and student academic performance by applying multilevel modeling to the 1996 National Assessment of Educational Progress in mathematics. The study finds that the effects of classroom practices, when added to those of other teacher characteristics, are comparable in size to those of student background, suggesting that teachers can contribute as much to student learning as the students themselves.
Investigating gaze-supported multimodal pan and zoom

Remote pan-and-zoom control for the exploration of large information spaces is of interest for various application areas, such as browsing through medical data in sterile environments or investigating geographic information systems on a distant display. In this context, considering a user's visual attention for pan-and-zoom operations could be of interest. In this paper, we investigate the potential of gaze-supported panning in combination with different zooming modalities: (1) a mouse scroll wheel, (2) tilting a handheld device, and (3) touch gestures on a smartphone. Thereby, it is possible to zoom in at a location a user currently looks at (i.e., gaze-directed pivot zoom). These techniques have been tested with Google Earth by ten participants in a user study. While participants were fastest with the already familiar mouse-only base condition, the user feedback indicates a particularly high potential of the gaze-supported pivot zooming in combination with a scroll wheel or touch gesture.
Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity

Survivin is an essential chromosomal passenger protein required for mitotic progression. It is also an inhibitor of apoptosis and can prevent caspase-mediated cell death. In addition, survivin levels are elevated in cancer cells where its presence correlates with increased resistance to chemo- and radio-therapy, which makes it an attractive target for novel anti-cancer strategies. Interestingly, survivin is phosphorylated by the mitotic kinase, cdk1, and a non-phosphorylatable form, survivinT34A, cannot inhibit apoptosis. Here we rigorously test the ability of survivinT34A and its corresponding phosphomimetic, survivinT34E, to promote cell viability through survivin’s dual role. The effects of these mutations are diametrically opposed: survivinT34A accelerates cell proliferation and promotes apoptosis, whereas survivinT34E retards growth and promotes survival. Thus the phosphorylation status of survivin at T34 is pivotal to a cell’s decision to live or die.
Title : OVERVIEW OF RECENT PROGRESS IN FIRE SUPPRESSION TECHNOLOGY

1 SUMMARY In recent years, with the halon phase-out, there has been a major thrust towards finding new advanced fire suppression systems. Some of the newly developed fire suppression systems include halocarbon and inert gaseous agents, water mist systems, compressed-air-foam systems, and aerosol and gas generators. Halocarbon agents are chemicals similar to halon except that its molecular structure was modified to reduce or eliminate the chlorine and bromine atoms that are responsible for ozone depletion. They can extinguish fires at their design concentration, however, they produce Thermal Decomposition Products (TDP) including hydrogen fluoride (HF) at much higher levels than halon. Inert gas agents extinguish fire by oxygen depletion. They have zero ODP and no Global Warming potential, and they are not subject to thermal decomposition when used in extinguishing fires. However, they require high-pressure storage cylinders which has implications for space and weight. Fire suppression by water mist is mainly by a physical mechanism. Water mist fire suppression systems have demonstrated a number of advantages, such as good fire suppression capability, no environmental impact and no toxicity. However, water mist does not behave like a total flooding agent, thus the fire suppression effectiveness of water mist depends on the potential size of the fire, properties of the combustibles, and the degree of obstruction, as well as the water mist characteristics. Aerosol systems produce micron size dry chemical particles and gas products, and extinguish fires by removing and recombining flame propagation radicals and by absorbing heat. Gas generators produce a large quantity of inert gases by combustion of solid propellants, and extinguish fires by oxygen depletion. All of the recently developed fire suppression systems extinguish fires at their design conditions, however, no one system can be chosen as the best system for all applications. Some perform better than others in a particular application. All have some limitations and concerns that have to be dealt with in extinguishing fires.
Oral Antimicrobial Rinse to Reduce Mycobacterial Culture Contamination among Tuberculosis Suspects in Uganda: A Prospective Study

Rationale Contamination by bacterial or fungal organisms reduces the effectiveness of mycobacterial culture for diagnosis of pulmonary tuberculosis (TB). We evaluated the effect of an anti-microbial and an anti-fungal oral rinse prior to expectoration on culture-contamination rates. Methods We enrolled a consecutive random sample of adults with cough for ≥2 weeks and suspected TB admitted to Mulago Hospital (Kampala, Uganda) between October 2008 and June 2009. We randomly assigned patients to oral rinse (60 seconds with chlorhexidine followed by 60 seconds with nystatin) vs. no oral rinse prior to initial sputum collection. Uganda National Tuberculosis Reference Laboratory technicians blinded to the method of sputum collection (with or without oral rinse) processed all sputum specimens for smear microscopy (direct Ziehl-Neelsen) and mycobacterial culture (Lowenstein-Jensen media). Results Of 220 patients enrolled, 177 (80%) were HIV-seropositive (median CD4-count 37 cells/uL, IQR 13–171 cells/uL). Baseline characteristics were similar between patients in the oral-rinse (N = 110) and no oral-rinse (N = 110) groups. The proportion of contaminated cultures was significantly lower in the oral-rinse group compared to the no oral-rinse group (4% vs. 15%, risk difference −11%, 95% CI −18 to −3%, p = 0.005). Oral rinse significantly reduced the proportion of contaminated cultures among HIV-infected patients (3% vs. 18%, risk difference −14%, 95% CI −23 to −6%, p = 0.002) but not HIV-uninfected (6% vs. 4%, risk difference 2%, 95% CI −12 to +15%, p = 0.81) patients. However, the proportion of smear-positive specimens (25% vs. 35%, p = 0.10) and culture-positive specimens (48% vs. 56%, p = 0.24) were lower in the oral-rinse compared to the no oral-rinse group, although the differences were not statistically significant. Conclusions Oral rinse prior to sputum expectoration is a promising strategy to reduce mycobacterial culture contamination in areas with high HIV prevalence, if strategies can be devised to reduce the adverse impact of oral rinse on smear- and culture-positivity.
Relative Contributions of Caregivers’ Level of Education, Role Definition and Average Household Income to caregiver Involvement in Children’s Emergent Reading

Recent studies have consistently reported low reading achievement levels among primary school children in Kenya. Reading is a very critical component of children’s development. Many aspects of learning at school revolve around this skill. Being the media via which other subjects are taught and learnt, reading is very significant and could contribute to failure in school. Reading is not only a school agenda. Children also acquire early reading skills through specific experiences at home that require support of other adults besides teachers. Parent involvement in children’s early reading development has been found to play a very critical role in the child’s later reading success. Parents who take an active role in children’s reading foster children’s lifelong passion for reading, which in turn lead to improved children’s performance in learning at school. However, majority of the parents do not perceive themselves as crucial partners in children’s emergent reading development. This paper is based on a study that compared the relative contributions of the parents’ level of education, parents’ role definition and the average household income, to parents’ involvement in children’s emergent reading development. The authors argue that although these three factors positively correlate with parents’ involvement in children’s reading development, parents’ perceptions about their role in children’s reading development is the most important predictor of their’ involvement in terms of direct and indirect behaviours and strategies with children around print. Interventions to improve reading achievement levels need to address parent involvement in children’s reading. Such interventions should place priority in helping parents to correctly define their role in this important aspect of children’s development.
Prognostic factors in methanol poisoning

The aim of this study was to assess the clinical and laboratory factors in methanol poisoned patients to determine the prognosis of their toxicity. This survey was done as a prospective cross-sectional study in methanol-poisoned patients in Loghman-Hakim hospital poison center during 9 months from October 1999—June 2000. During this time 25 methanol-poisoned patients were admitted. The mortality rate was 12 (48%). Amongst survivors, three (23%) of the patients developed blindness due to their poisoning and the other 10 (77%) fully recovered without any complication. The mortality rate in comatose patients was nine (90%) while in non-comatose patients it was three (20%) (P < 0.001). There was a significant difference in mean pH in the first arterial blood gas of patients who subsequently died (6.82 ± 0.03) and survivors (7.15 ± 0.06) (P < 0.001, M-W). The mean time interval between poisoning and ED presentation in deceased patients were (46 ± 15.7) hours, in survived with sequelae were (16.7 ± 6.7) and in survived without sequelae were (10.3 ± 7.2) hours (P < 0.002, K-W). We found no significant difference between the survivors versus the patients who died regarding methanol. Simultaneous presence of ethanol and opium affected the outcome of the treatment for methanol intoxication favourably and unfavourably, respectively. In our study, poor prognosis was associated with pH < 7, coma on admission and >24 hours delay from intake to admission. Human & Experimental Toxicology (2007) 26: 583—586.
A survey of recent innovations in vibration damping and control using shunted piezoelectric transducers

Research on shunted piezoelectric transducers, performed mainly over the past decade, has generated new opportunities for control of vibration and damping in flexible structures. This is made possible by the strong electromechanical coupling associated with modern piezoelectric transducers. In vibration control applications, a piezoelectric transducer is bonded to, or embedded in a base structure. As the structure deforms, the piezoelectric element strains and converts a portion of the structural vibration energy into electrical energy. By shunting the piezoelectric transducer to an electrical impedance, a part of the induced electrical energy can be dissipated. Hence, the impedance acts as a means of extracting mechanical energy from the base structure. This paper reviews recent research related to the use of shunted piezoelectric elements for vibration damping and control. In particular, the paper presents an overview of the literature on piezoelectric shunt damping and discusses recent observations on the feedback nature of piezoelectric shunt damping systems.
Survival of the recombinant Bacteroides thetaiotaomicron strain BTX in in vitro rumen incubations

The survival of Bacteroides thetaiotaomicron strain BTX under rumen‐simulating conditions was studied. Strain BTX is a recombinant variant of strain 5482 engineered for the production of high levels of xylanase, an enzyme important in the degradation of hemicellulose. Strain BTX was not inhibited by compounds present in rumen fluid and it grew well in media containing rumen fluid (up to 75%) or high concentrations of volatile fatty acids (total concentration, 100 mmol l−1). The ability of strain BTX to compete with other micro‐organisms under rumen‐like conditions was studied in in vitro incubations of rumen contents. These experiments employed a consecutive batch culture (CBC) system consisting of alfalfa suspended in a rumen fluid buffer inoculated with blended rumen contents and maintained by transfers (10%, v/v) at 48 h intervals. CBC cultures contained a diversity of microbial morphotypes and accumulated fermentation products in rumen‐like proportions. When added alone, the numbers of BTX cells were maintained for only a few hours, and then declined precipitously until undetectable after 48 h. If CBC cultures were also supplemented with chondroitin sulphate (a mucopolysaccharide used by Bact. thetaiotaomicron), strain BTX grew and the pattern of its population generally followed that of the total population of ruminal bacteria in these cultures. When transferred into fresh CBC cultures containing chondroitin sulphate, BTX was again able to grow and increase in numbers, but to a diminished degree. Although BTX was able to survive and maintain itself in chondroitin sulphate supplemented cultures, this was at a very low level (1010 ml−1). The potential for manipulation of rumen function by inoculation with recombinant bacteria is discussed.
Inhomogeneous transmural conduction during early ischaemia in patients with coronary artery disease.

Electrical inhomogeneity and conduction slowing are critical factors in the initiation and maintenance of ventricular arrhythmias during early ischaemia. Studies in animal models have shown delay in epicardial activation compared to endocardial activation. Epicardial activation delay has been attributed to either enhanced sensitivity of epicardium to ischaemia or to mid-myocardial conduction delay. No information is available in humans and in particular in patients with chronic ischaemia due to coronary artery disease who may have altered electrophysiological properties. Twenty-three patients undergoing routine coronary surgery were studied. All had severe two or three vessel coronary artery disease and a documented history of angina for a mean of 2.4 years. On cardiopulmonary bypass a 3 min period of ischaemia was created by cross clamping the aorta between the input from the pump oxygenator and the coronary arteries. During atrial pacing (normal endocardial to epicardial activation) intramyocardial activation time within the left ventricular free wall between subendocardial and subepicardial plunge electrode terminals, increased from 12.7+/-1.5 ms (control) to 28.2+/-3.2 ms after 3 min ischaemia at the base. At the apex, the activation time increase (over the same distance) was less (19.5+/-2 ms at 3 min ischaemia). This difference in increase in activation time at the base and apex was significant (P<0.05). At the apex the ischaemia induced activation delay occurred primarily over the endocardial half of the wall, whereas the opposite was observed at the base of the heart. Using an epicardial electrode array stimulation along the long axis of the epicardial fibres showed minimal conduction delay during ischaemia whereas stimulation transverse to the epicardial fibres resulted in substantial conduction time prolongation, as was the case with intramural conduction. Intramural conduction during ischaemia was similar in non-infarcted regions of infarcted hearts compared to hearts with no previous MI. To conclude, in patients with coronary artery disease epicardial activation delay early during ischaemia is caused primarily by intramural delay and not by delay along the epicardium. Moreover, the ischaemia-induced transmural activation delay is inhomogeneous.
Advances in high-resolution mass spectrometry based on metabolomics studies for food – a review

Food authenticity becomes a necessity for global food policies, since food placed in the market without fail has to be authentic. It has always been a challenge, since in the past minor components, called also markers, have been mainly monitored by chromatographic methods in order to authenticate the food. Nevertheless, nowadays, advanced analytical methods have allowed food fingerprints to be achieved. At the same time they have been also combined with chemometrics, which uses statistical methods in order to verify food and to provide maximum information by analysing chemical data. These sophisticated methods based on different separation techniques or stand alone have been recently coupled to high-resolution mass spectrometry (HRMS) in order to verify the authenticity of food. The new generation of HRMS detectors have experienced significant advances in resolving power, sensitivity, robustness, extended dynamic range, easier mass calibration and tandem mass capabilities, making HRMS more attractive and useful to the food metabolomics community, therefore becoming a reliable tool for food authenticity. The purpose of this review is to summarise and describe the most recent metabolomics approaches in the area of food metabolomics, and to discuss the strengths and drawbacks of the HRMS analytical platforms combined with chemometrics. Graphical Abstract
Musculoskeletal pain illness perceptions: Factor structure of the Illness Perceptions Questionnaire-Revised

Background: The Revised Illness Perceptions Questionnaire (IPQ-R) is commonly used to measure illness perceptions. We tested whether the structure of the IPQ-R was appropriate for use with primary care musculoskeletal pain patients. Methods: Confirmatory (C) and exploratory (E) factor analyses (FA) were used to test whether the structure of the IPQ-R was supported for patients with knee pain (n = 393), hand pain (n = 2113) and back pain (n = 1591). CFA was used to test whether the timeline acute/chronic, timeline cyclical, consequences, personal control, treatment control, illness coherence and emotional representation dimensions of the IPQ-R were distinct; EFA was used to explore potential structure for patients’ views on the cause of their condition. Results: Goodness-of-fit indices for the CFA were below our criteria for good model fit. Removal of six items from the model improved model fit, but our criteria for good model fit was still not achieved. An interpretable factor solution could not be determined for the causal items on the questionnaire. Conclusions: Our data show limited evidence that the seven dimensions of the IPQ-R are distinct. A clear structure for the causal items was not determined. Further work is needed to develop the IPQ-R for use with primary care musculoskeletal pain patients.