Miracle-dz/UniFAR-FTUs huggingface dataset:
INTEGRAL and XMM‐Newton Observations of AX J1845.0‐0433

AX J1845.0–0433 is a persistent X‐ray binary with a O9.5I supergiant companion emitting at a low 0.2–100 keV luminosity of 1035 ergs−1 with seldom flares reaching luminosities of 1036 ergs−1. Variability factors of 50 are observed on short time‐scales of a few ks. The broad‐band, high‐energy spectrum is typical of wind‐fed accreting pulsars (absorption NH = (2.6±0.2)1022 cm−2, hard continuum Γ = (0.7–0.9)±0.1, high‐energy cutoff Ecut = 16−3+5 keV). An excess at low energies is also observed (fitted with black body KT = 0.18±0.05 keV). Optically‐thin and highly‐ionised iron (Fe XVIII–XIX) located near the NS (≲0.4 R*) is also observed. No spectral variations are observed between the flare and quiescence phases except the luminosity and the absorption depth of the iron 7.9 keV edge. The flare characteristics, in contrast to the persistent quiescent emission, suggest that clumps are formed within the stellar wind of the supergiant companion.
Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases

Purpose. Interleukin 6 (IL-6) plays a crucial role in both adaptive and innate immunity. The rs1800795 gene polymorphism of IL-6 is associated with various autoimmune diseases, like multiple sclerosis. Methods. 134 patients with HLAB27 positive iridocyclitis, 84 patients with intermediate uveitis, 132 controls, and 65 HLAB27 positive controls were recruited for the present case-control study. Main outcome measures were genotype distribution and allelic frequencies determined by polymerase chain reaction. Results. The frequency of carriers of the minor allele for rs1800795 was significantly higher in patients with intermediate uveitis compared to controls (p = 0.04; OR: 1.46; CI: 1.02–2.11). Frequencies of the minor allele for rs1800795 did not differ significantly in patients with HLAB27 associated uveitis when compared to controls (p > 0.05). Conclusion. These findings further deepen our understanding of the commonality between multiple sclerosis and intermediate uveitis. Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets.
Meta-Specification and Cataloging of Software Patterns with Domain Specific Languages and Adaptive Object Models

Abstract Writing patterns is a very important task for leveraging knowledge within an organization or in the software engineering community as a whole. Patterns are more than text, diagrams or source code. Patterns are knowledge that comes from experience. Sharing patterns is sharing knowledge. Currently, an abstract and standardized way for specifying software patterns doesn’t exist. There isn’t any single meta-definition model that governs patterns description. This leads to the problem of finding a way to represent patterns in a self-contained that leverages the literary information and the implementation information independent of the programming languages and execution platform and a way for sharing those patterns. The creation of a language for pattern meta-specification and a catalog of patterns from different pattern languages described using this language is a clear step towards the solution of this problem. The creation of a web-based visualization tool for the catalog makes this knowledge available to the world, allowing searching, linking and using the patterns in the catalog. In this paper, we will present the advances and results of our research work on meta-specification and cataloging of software patterns. Keywords: patterns, Meta, meta-specification, classification, patterns browser, pattern oriented software engineering, domain specific languages, adaptive object model, knowledge management.
Numerical Calibration and De-embedding Techniques for CAD and Equivalent Circuit Models of Electromagnetic Structures

-The numerical calibration and de-embedding techniques used in the planar electromagnetic (EM) simulation are reviewed. These techniques are used to eliminate the port discontinuities brought by the current/voltage exciting source. Therefore, accurate equivalent circuit model of the planar discontinuities can be extracted. Index Terms – calibration technique, equivalent circuit model, planar discontinuity and circuit, full-wave electromagnetic simulation.
FAILURE AND RECOVERY OF ENTANGLED POLYMER MELTS IN ELONGATIONAL FLOW

Entangled polymer melts exhibit failure in elongational flow, with different failure modes characteristic of different Weissenberg number regimes. Theoretical attempts to predict failure include Reiner’s dynamical theory of strength, the Considere construction for the onset of necking, and a scaling theory that associates rupture with a critical recoverable strain. Reiner’s theory is not consistent with the overall trend of available data, and the Considere construction does not appear to be applicable to melt flow in regimes with dissipation. The scaling theory is in qualitative agreement with available data but falls short quantitatively, and predictive capability of failure in elongational flow remains an elusive goal. An understanding of rupture and its relation to recovery, if any, is hindered by the extremely limited experimental database on rupture and recovery of well-characterized polymers.
Interplay Between Connexin40 and Nitric Oxide Signaling During Hypertension

Connexins (Cxs) and endothelial nitric oxide synthase (eNOS) contribute to the adaptation of endothelial and smooth muscle cells to hemodynamic changes. To decipher the in vivo interplay between these proteins, we studied Cx40-null mice, a model of renin-dependent hypertension which displays an altered endothelium-dependent relaxation of the aorta because of reduced eNOS levels. These mice, which were either untreated or subjected to the 1-kidney, 1-clip (1K1C) procedure, a model of volume-dependent hypertension, were compared with control mice submitted to either the 1K1C or the 2-kidney, 1-clip (2K1C) procedure, a model of renin-dependent hypertension. All operated mice became hypertensive and featured hypertrophy and altered Cx expression of the aorta. The combination of volume- and renin-dependent hypertension in Cx40−/− 1K1C mice raised blood pressure and cardiac weight index. Under these conditions, all aortas showed increased levels of Cx40 in endothelial cells and of both Cx37 and Cx45 in smooth muscle cells. In the wild-type 1K1C mice, the interactions between Cx40 and Cx37 with eNOS were enhanced, resulting in increased NO release. The Cx40–eNOS interaction could not be observed in mice lacking Cx40, which also featured decreased levels of eNOS. In these animals, the volume overload caused by the 1K1C procedure resulted in increased phosphorylation of eNOS and in a higher NO release. The findings provide evidence that Cx40 and Cx37 play an in vivo role in the regulation of eNOS.
Emotion Regulation in Alcohol Dependence.

BACKGROUND The main aim of this study was to investigate, in alcohol-dependent (AD) patients, the use of the 5 emotion regulation strategies specified in Gross's (1998, Rev Gen Psychol, 2, 271) process model of emotion regulation with the use of a semi-structured interview allowing a detailed and high-quality assessment of emotion regulation strategies. A secondary aim was to examine the possible influence of protracted abstinence and detoxification on emotion dysregulation. Finally, the association between the level of craving and the types of regulation strategies was investigated. METHODS Forty-four treatment-seeking AD patients with varying time spent in rehabilitation, and 26 healthy controls were interviewed using a version of the Emotion Regulation Interview (Werner et al., 2011, J Psychopathol Behav Assess, 33, 346) adapted to alcohol dependence. RESULTS Compared to controls, AD patients reported significantly greater use of response modulation and attentional deployment, but lesser use of cognitive change. Among patients, (1) rehabilitation duration was positively correlated with the use of cognitive change and (2) the use of response modulation was positively associated with the level of craving. CONCLUSIONS These findings clarify the specific pattern of emotion dysregulation associated with alcohol dependence. They also suggest that (1) abstinence is associated with a shift toward more adaptive emotion regulation patterns and that (2) inefficient regulation strategies may lead to craving and the maintenance of alcohol use. If these findings are confirmed through longitudinal and mediation designs, they will have important clinical implications.
Codesign of Embedded Systems with Process/Module Level Real-Time Deadlines

We present a codesign method that synthesizes heterogeneous multiple processing element embedded systems with real-time constraints. Hardware/software partitioning is performed using Genetic algorithm. The proposed cosynthesis method explores various target architectures and one of them is an optimized architecture of the system. The method is capable of producing feasible solutions for large-scale real-time embedded systems. Non-preemptive and conditional preemptive scheduling techniques are employed that can deal with module (application) and process level deadlines. The method also supports communication-link allocation and communication events scheduling and the method also achieves better CPU utilization.
The relationship between selected personality characteristics and Rod and Frame Test performance.

A l a r g e number o f s t u d i e s h a v e f o c u s e d on t h e p e r s o n a l i t y c h a r a c t e r i s t i c s a s s o c i a t e d w i t h p e r c e p t u a l f i e l d d e p e n d e n c e . A l t h o u g h t h e r e v i e w o f t h e l i t e r a t u r e i n d i c a t e d t h a t some c o n s i s t e n t r e s u l t s h a v e been r e p o r t e d , i t a p p e a r s t h a t many o f t h e p e r s o n a l i t y c h a r a c t e r ­ i s t i c s a s s o c i a t e d w i t h f i e l d d e p e n d e n c e r e m a in a m a t t e r o f d e b a t e . The p r e s e n t s t u d y i n v e s t i g a t e d t h e r e l a t i o n s h i p be tw een f i e l d d e ­ p e n d e n c e , m e a s u r e d by t h e Rod and Frame T e s t (RFT), and a number o f p e r s o n a l i t y c h a r a c t e r i s t i c s s e l e c t e d f o r t h e i r h y p o t h e s i z e d r e l e v a n c e t o s o c i a l b e h a v i o r . The r e s u l t s o f t h e p r e s e n t s t u d y i n d i c a t e d t h a t : ( 1 ) h i g h ( f i e l d d e p e n d e n t ) and low ( f i e l d i n d e p e n d e n t ) RFT s c o r e r s d i d n o t d i f f e r s i g n i f i c a n t l y i n J a c k s o n P e r s o n a l i t y I n v e n t o r y ( JP1) p r o f i l e , b u t t h e z s c o r e s r e p r e s e n t i n g t h e J P I p r o f i l e s o f t h e two RFT g r o u p s d i d n o t o v e r l a p c o m p l e t e l y and 38 o f 41 s u b j e c t s w e r e c l a s s i f i e d c o r r e c t l y a s e i t h e r h i g h o r low RFT s c o r e r s , ( 2 ) a m e a s u r e o f r e l ­ a t i v e l y g e n e r a l i z e d ( t r a i t ) a n x i e t y on t h e J P I showed a s i g n i f i c a n t p o s i t i v e c o r r e l a t i o n w i t h t h e RFT, b u t m e a s u r e s o f momentary a n x i e t y d u r i n g RFT t e s t i n g showed g e n e r a l l y low, non s i g n i f i c a n t c o r r e l a t i o n s w i t h t h e RFT, (3 ) t h e r e s u l t s o f a p r e v i o u s s t u d y ( R o s e n f e l d , 1967) w h ic h r e p o r t e d a s i g n i f i c a n t r e l a t i o n s h i p be tw een h i g h RFT s c o r e s and d e s i r a b l e r e s p o n d i n g on t h e Marlowe-Crowne S o c i a l D e s i r a b i l i t y s c a l e w e r e n o t c o n f i r m e d .
Treatment strategies for Hodgkin lymphoma recurring following autologous hematopoietic stem cell transplantation

Hodgkin lymphoma (HL) represents one of the great success stories in hematology going from a uniformly fatal disease, to one that is curable in the vast majority of cases. Despite this success, some patients experience relapse. To address this unmet need a variety of agents, classes of drugs, and strategies have demonstrated activity in HL recurring after autologous hematopoietic stem cell transplantation. These include chemotherapeutics (gemcitabine-based combinations, bendamustine), histone deacetylase (HDAC) inhibitors (panobinostat), immunomodulatory agents (lenalidomide), mTOR inhiobitors (everolimus), monoclonal antibodies (rituximab), and antibody-drug conjugates (brentuximab vedotin) as well the potential of long-term disease control via allogeneic transplantation. Such advances reflect our increased understanding of the biology of HL and hold promise for continued improved outcomes for those suffering with this condition.
NUMERICAL SOLUTION OF OBSTACLE SCATTERING PROBLEMS

Some novel numerical approaches to solving direct and inverse ob- stacle scattering problems are presented. Scattering by nite obstacles and by periodic structures is considered. The emphasis for solving direct scattering prob- lem is on the Modied Rayleigh Conjecture method, recently introduced and tested by the authors. This method is used numerically in scattering by nite obstacles and by periodic structures. Numerical results it produces are very encouraging. The support function method for solving the inverse obstacle scattering problems is described and tested in some examples. Analysis of the various versions of linear sampling methods is given, and the limitations of these methods are described.
Chapter 20 : National Surveillance of Vaccine-Preventable Diseases *

The national reporting system for infectious diseases in the United States was initially an archival system designed to document trends in disease occurrence rather than to provide epidemiologically important information needed for prevention and control of diseases. 1,2 As national immunization programs developed, so did the need for surveillance of vaccine-preventable diseases. The first major support for immunization at the federal level came following the licensure of inactivated poliomyelitis vaccine (IPV) in 1955. During the 2 weeks following the announcement of the results from the successful field trial of this polio vaccine, approximately 4 million doses of vaccine were administered, mostly to elementary schoolchildren. On April 25, 1955, an infant with paralytic poliomyelitis was admitted to a Chicago hospital, 9 days following vaccination with IPV. The next day, five additional cases of paralytic poliomyelitis were reported from California among children who had received vaccine produced by the same manufacturer of the vaccine administered to the child in Chicago. In each case, paralysis first developed in the limb in which vaccine had been given. On April 27, 1955, the Surgeon General asked the manufacturer to recall all remaining lots of vaccine. The following day, the Poliomyelitis Surveillance Unit was established at the Communicable Diseases Center (now the Centers for Disease Control and Prevention [CDC]).
Assessing externalizing and internalizing behaviour in children: use of the motor behaviour checklist in a typical school-age Polish sample

The study was designed to investigate externalizing and internalizing behaviours in a typical school-aged sample of children (N=112) using the Polish version of the Motor Behaviour Checklist for Children. The instrument was translated into Polish and teachers observed and recorded the motor behaviour of their students in school settings during physical education and free play situations. Findings demonstrated a psychometrically robust application of the MBC in a Polish sample as well as gender differences in total externalizing scores. In addition, age was found to be significant correlated with internalizing scores and especially with the social interaction factor. Teachers reported boys as more inattentive and more hyperactive/impulsive than girls and more likely to display externalising symptoms connected with ADHD particularly in school settings. Findings underscore the importance of early diagnosis and have practical implications when designing behavioural management programs and educational interventions in school settings.
Query-log mining for detecting polysemy and spam

Through their interaction with search engines, users provide implicit feedback that can be used to extract useful knowledge and improve the quality of the search process. This feedback is encoded in the form of a query log that consists of a sequence of search actions, which contain information about submitted queries, documents viewed, and documents clicked by the users. In this paper, we propose characterizing documents and queries via the information available within a query log, with the goal of detecting either query polysemy or spam-hosts and spam-queries, i.e., queries that shown the undesirable property of showing a higher rate of spam pages in their list of results than other queries. The main contribution of our paper consists of exploiting user feedback and query-log mining to combat spam and identify query polysemy. Our experiments attest the effectiveness of our approach for the applications
Matrix Metalloproteinase-20 Over-Expression Is Detrimental to Enamel Development: A Mus musculus Model

Background Matrix metalloproteinase-20 (Mmp20) ablated mice have enamel that is thin and soft with an abnormal rod pattern that abrades from the underlying dentin. We asked if introduction of transgenes expressing Mmp20 would revert this Mmp20 null phenotype back to normal. Unexpectedly, for transgenes expressing medium or high levels of Mmp20, we found opposite enamel phenotypes depending on the genetic background (Mmp20−/− or Mmp20+/+) in which the transgenes were expressed. Methodology/Principal Findings Amelx-promoter-Mmp20 transgenic founder mouse lines were assessed for transgene expression and those expressing low, medium or high levels of Mmp20 were selected for breeding into the Mmp20 null background. Regardless of expression level, each transgene brought the null enamel back to full thickness. However, the high and medium expressing Mmp20 transgenes in the Mmp20 null background had significantly harder more mineralized enamel than did the low transgene expresser. Strikingly, when the high and medium expressing Mmp20 transgenes were present in the wild-type background, the enamel was significantly less well mineralized than normal. Protein gel analysis of enamel matrix proteins from the high and medium expressing transgenes present in the wild-type background demonstrated that greater than normal amounts of cleavage products and smaller quantities of higher molecular weight proteins were present within their enamel matrices. Conclusions/Significance Mmp20 expression levels must be within a specific range for normal enamel development to occur. Creation of a normally thick enamel layer may occur over a wider range of Mmp20 expression levels, but acquisition of normal enamel hardness has a narrower range. Since over-expression of Mmp20 results in decreased enamel hardness, this suggests that a balance exists between cleaved and full-length enamel matrix proteins that are essential for formation of a properly hardened enamel layer. It also suggests that few feedback controls are present in the enamel matrix to prevent excessive MMP20 activity.
Testing for Mean-Variance Spanning with Short Sales Constraints and Transaction Costs: The Case of Emerging Markets

We propose regression-based tests for mean-variance spanning in the case where investors face market frictions such as short sales constraints and transaction costs. We test whether U.S. investors can extend their efficient set by investing in emerging markets when accounting for such frictions. For the period after the major liberalizations in the emerging markets, we find strong evidence for diversification benefits when market frictions are excluded, but this evidence disappears when investors face short sales constraints or small transaction costs. Although simulations suggest that there is a possible small-sample bias, this bias appears to be too small to affect our conclusions. Copyright The American Finance Association 2001.
Asymmetry in cricket song: female preference and proximate mechanism of discrimination

SUMMARY Subtle random deviations from perfect symmetry in bilateral traits are suggested to signal reduced phenotypic and genetic quality of a sender, but little is known about the related receiver mechanisms for discriminating symmetrical from asymmetrical traits. Here, we investigated these mechanisms in behavioural and neurophysiological experiments in the Mediterranean field cricket, Gryllus bimaculatus. A downward frequency modulation at the end of each syllable in the calling song has been suggested to indicate morphological asymmetry in sound radiating structures between left and right forewings. Even under ideal laboratory conditions on a trackball system, female crickets only discriminated between songs of symmetrical and asymmetrical males in two-choice experiments at carrier frequencies of 4.4 kHz and a large modulation depth of 600 and 800 Hz. Under these conditions they preferred the pure-tone calling songs over the modulated (asymmetrical) alternative, whereas no preference was observed at carrier frequencies of 4.9 and 5.2 kHz. These preferences correlate well with the responses of a pair of identified auditory interneurons (AN1), known for their importance in female phonotaxis. The AN1 interneuron is tuned to an average frequency of 4.9 kHz, and the roll-off towards lower and higher frequencies determines the magnitude of responses to pure-tone and frequency-modulated calling songs. The difference in response magnitude between the two neurons appears to drive the decision of females towards the song alternatives. We discuss the relevance of song differences based on asymmetry in the morphology of song-producing structures under natural conditions.
Robustness of Learning That Is Based on Covariance-Driven Synaptic Plasticity

It is widely believed that learning is due, at least in part, to long-lasting modifications of the strengths of synapses in the brain. Theoretical studies have shown that a family of synaptic plasticity rules, in which synaptic changes are driven by covariance, is particularly useful for many forms of learning, including associative memory, gradient estimation, and operant conditioning. Covariance-based plasticity is inherently sensitive. Even a slight mistuning of the parameters of a covariance-based plasticity rule is likely to result in substantial changes in synaptic efficacies. Therefore, the biological relevance of covariance-based plasticity models is questionable. Here, we study the effects of mistuning parameters of the plasticity rule in a decision making model in which synaptic plasticity is driven by the covariance of reward and neural activity. An exact covariance plasticity rule yields Herrnstein's matching law. We show that although the effect of slight mistuning of the plasticity rule on the synaptic efficacies is large, the behavioral effect is small. Thus, matching behavior is robust to mistuning of the parameters of the covariance-based plasticity rule. Furthermore, the mistuned covariance rule results in undermatching, which is consistent with experimentally observed behavior. These results substantiate the hypothesis that approximate covariance-based synaptic plasticity underlies operant conditioning. However, we show that the mistuning of the mean subtraction makes behavior sensitive to the mistuning of the properties of the decision making network. Thus, there is a tradeoff between the robustness of matching behavior to changes in the plasticity rule and its robustness to changes in the properties of the decision making network.