Miracle-dz/UniFAR-FTUs huggingface dataset:
Initial reactions in anaerobic ethylbenzene oxidation by a denitrifying bacterium, strain EB1

Initial reactions in anaerobic oxidation of ethylbenzene were investigated in a denitrifying bacterium, strain EB1. Cells of strain EB1 mineralized ethylbenzene to CO2 under denitrifying conditions, as demonstrated by conversion of 69% of [14C]ethylbenzene to 14CO2. In anaerobic suspensions of strain EB1 cells metabolizing ethylbenzene, the transient formation and consumption of 1-phenylethanol, acetophenone, and an as yet unidentified compound were observed. On the basis of growth experiments and spectroscopic data, the unknown compound is proposed to be benzoyl acetate. Cell suspension experiments using H2(18)O demonstrated that the hydroxyl group of the first product of anoxic ethylbenzene oxidation, 1-phenylethanol, is derived from water. A tentative pathway for anaerobic ethylbenzene mineralization by strain EB1 is proposed.
Expression of insulin‐like growth factor‐binding protein messenger RNAs in developing rat oligodendrocytes and astrocytes

Insulin‐like growth factors, IGF‐I and IGF‐II, are potent regulators of oligodendrocyte development. Most of the IGF present in vivo is bound to members of a family of six high‐affinity IGF‐binding proteins (IGFBPs), which can either potentiate or inhibit IGF action, depending on other conditions. Additionally, serum contains a structurally unrelated protein, acid‐labile sub‐unit (ALS), which forms a ternary complex with IGF and IGFBP3. In this study, we used reverse‐transcriptase polymerase chain reaction (RT‐PCR) to examine the expression of mRNAs for IGFBP 1–6 and ALS in purified populations of oligodendroglial cells and astrocytes. We found that astrocytes express all six IGFBPs. A2B5+/O4− oligodendrocyte precursors, O4+/O1− intermediate precursors, and O1+ oligodendrocytes express IGFBP3, 5, and 6, while IGFBP4 is expressed in oligodendrocyte precursors but not at more mature stages. We were unable to detect ALS mRNA in whole brain or in cultured oligodendroglial cells. The presence of differentially expressed IGFBPs in developing oligodendrocytes and astrocytes could significantly affect the biological activity of IGF‐I and IGF‐II in the central nervous system and the IGF‐responsiveness of the IGFBP‐expressing cells. J. Neurosci. Res. 50:721–728, 1997. © 1997 Wiley‐Liss, Inc.
Dietary inflammatory index and endometrial cancer risk in an Italian case–control study

Abstract The relation between inflammation deriving from diet and endometrial cancer risk has not yet been investigated. In this study, we explored the association between the dietary inflammatory index (DII) and endometrial cancer risk in an Italian case–control study. Cases comprised 454 patients with incident, histologically confirmed carcinoma of the endometrium, and controls comprised 908 subjects admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. DII scores were computed on the basis of dietary intake assessed using a reproducible and valid seventy-eight-item FFQ. OR were calculated through logistic regression models conditioned on age and study centre and adjusted for recognised confounding factors, including total energy intake. Women with the most pro-inflammatory diet had a higher risk for endometrial cancer compared with women with the most anti-inflammatory diet (ORQuartile 4 v. 1 1·46; 95 % CI 1·02, 2·11; P trend=0·04). A pro-inflammatory diet may increase the risk for endometrial cancer.
STUDENT-DIRECTED PROJECTS: AN INTERNATIONAL CASE STUDY FOR SOCIAL WORK EDUCATION

Student-directed projects are increasingly becoming a common phenomenon in schools of social work across the United States. Students acquire a great learning experience from these projects, which sharpen their skills in leadership, innovation, and practice. Social work practitioners who go through such a process emerge having acquired knowledge beyond what is offered in the classroom. In this article we present a case study of 5 African graduate students who engaged in innovative efforts to implement a social development intervention in Uganda. The discussion includes ways to support students who embark on student-directed projects in schools of social work.
Analysis of Radiographic Characteristics of Anterolateral Bowing of the Leg Before Fracture in Neurofibromatosis Type 1

Background: Anterolateral leg bowing is associated with neurofibromatosis type 1 (NF1) frequently leading to fracture and nonunion of the tibia. The objective of the study was to characterize the radiographic findings of tibial dysplasia in NF1. Methods: This study is a retrospective review of radiographs of tibial dysplasia obtained within 52 years, between 1950 and 2002, from the Shriners Hospitals for Children, Salt Lake City, and of peripheral quantitative computed tomographic images of 3 individuals with anterolateral bowing of the leg without fracture compared with age- and sex-matched controls. Results: Individuals with NF1 with bowing of the leg have the appearance of thicker cortices with medullary narrowing on plain film radiographs. The peripheral quantitative computed tomographic images of individuals with NF1 with anterolateral bowing show an unusual configuration of the tibia. Conclusions: Anterolateral bowing of the leg in NF1 is associated with the appearance of thicker cortices with medullary narrowing rather than thinning of the long bone cortex on plain film radiographs as currently used as a qualifier in the sixth diagnostic criterion for the clinical diagnosis of NF1. Individuals with NF1 who have anterolateral bowing of the leg have differences in tibial geometry compared with age- and sex-matched controls. Clinical Relevance: The characterization of the radiographic findings of long bone bowing in NF1 helps clarify the NF1 clinical diagnostic criteria.
Giving a European Dimension to Civil Society Organizations

Abstract This paper investigates the efforts by EU institutions, above all the Commission, to give a ‘European dimension’ to national and EU-level civil society organizations. The array of instruments and different paths available to induce associations of different kinds to ‘go European’ are highlighted: Funding programmes, campaigning, incentives to build transnational networks, and new consultation and involvement strategies. Empirical evidence regarding their effect on civil society organizations is taken from voluntary organizations working in the field of humanitarian aid, development, human rights, and social exclusion.
STABILITY OF ZOOM AND FIXED LENSES USED WITH DIGITAL SLR CAMERAS

Consumer grade digital cameras are widely used for close range photogrammetric applications because of the convenience of digital images and the low cost of capture and reproduction. Since the introduction of digital cameras in the 1980s, there has been a strong divide between relatively inexpensive, low resolution, compact digital cameras, and relatively expensive, high resolution, professional digital cameras. In recent years, the improved affordability of SLR (Single Lens Reflex) style digital cameras has increased the use of this class of camera, to some degree displacing professional cameras. Digital cameras are quite often bundled with a consumer grade zoom lens that is designed for the quality of the image, rather than the geometric stability of the calibration. When these cameras are used for photogrammetric applications, it is common practice that a high quality, fixed focal length lens is purchased and used in preference to the zoom lens. Calibration tests were conducted on a range of different digital cameras, all within the SLR class, to ascertain the differences between zoom and fixed lenses when used with these cameras. Analyses are presented that indicate the differences between the two lens types in terms of accuracy, precision and stability and suggest that although acceptable results can be obtained using zoom lenses, a fixed lens provides superior results.
O-Linked N-Acetylglucosamine Cycling Regulates Mitotic Spindle Organization*

Background: The addition or removal of the O-GlcNAc post-translational modification (O-GlcNAc cycling) regulates mitotic progression. Results: Increased O-GlcNAc cycling disrupted spindle size and shape partially through the loss of Aurora kinase B phosphorylation of histones. Inhibition of O-GlcNAc removal rescued the spindle phenotype. Conclusion: These data suggest that O-GlcNAc cycling is a requirement for spindle function. Significance: Proper spindle development requires O-GlcNAc cycling. Any defects in the correct formation of the mitotic spindle will lead to chromosomal segregation errors, mitotic arrest, or aneuploidy. We demonstrate that O-linked N-acetylglucosamine (O-GlcNAc), a post-translational modification of serine and threonine residues in nuclear and cytoplasmic proteins, regulates spindle function. In O-GlcNAc transferase or O-GlcNAcase gain of function cells, the mitotic spindle is incorrectly assembled. Chromosome condensation and centrosome assembly is impaired in these cells. The disruption in spindle architecture is due to a reduction in histone H3 phosphorylation by Aurora kinase B. However, gain of function cells treated with the O-GlcNAcase inhibitor Thiamet-G restored the assembly of the spindle and partially rescued histone phosphorylation. Together, these data suggest that the coordinated addition and removal of O-GlcNAc, termed O-GlcNAc cycling, regulates mitotic spindle organization and provides a potential new perspective on how O-GlcNAc regulates cellular events.
Striving for Disciplinary Literacy Instruction: Cognitive Tools in a World History Course

Abstract The authors present a case study of a world history teacher's mediation of her students' world historical thinking and writing through unit-level cognitive tools. They analyze both scaffolding and disciplinary tools that the teacher constructed for her students in order to improve their world historical thinking, and the degree to which the students used these supports. Ms. Stark's World History classroom and her teaching provide an instructive case that highlights potential avenues for supporting the development of historical disciplinary literacy and gives insight into the challenges in helping students make sense of large amounts of time and space in world history. This article corroborates research on the challenges of using scaffolding tools to teach history and the complexity of teaching disciplinary literacy, and illustrates the importance of close examinations of how teachers scaffold student acquisition of important disciplinary tools that support their thinking and writing in history in general and world history in particular.
When fold is not important: A common structural framework for adenine and AMP binding in 12 unrelated protein families

ATP is a ligand common to many proteins, yet it is unclear whether common recognition patterns do exist among the many different folds that bind ATP. Previously, it was shown that cAMP‐dependent protein kinase, D‐Ala:D‐Ala ligase and the α‐subunit of the α2β2 ribonucleotide reductase do share extensive common structural elements for ATP recognition although their folds are different. Here, we have made a survey of structures that bind ATP and compared them with the key features seen in these three proteins. Our survey shows that 12 different fold types share a specific recognition pattern for the adenine moiety, and 8 of these folds have a common structural framework for recognition of the AMP moiety of the ligand. The common framework consists of a tripeptide segment plus three additional residues, which provides similar polar and hydrophobic interactions between the protein and mononucleotide. Consensus interactions are represented by four key hydrogen bonds present in each fold type. Two of these four hydrogen bonds, together with three aliphatic residues, form a specific recognition pattern for the adenine moiety in all 12 folds. These similarities point to a structural‐functional requirement shared by these different mononucleotide‐binding proteins that represent at this time 28% of the adenine mononucleotide complexes found in the Brookhaven Protein Data Bank. Proteins 2000;38:310–326. © 2000 Wiley‐Liss, Inc.
Verbal selective learning after traumatic brain injury in children

Selective learning (SL), the ability to select items to learn from among other items, engages cognitive control, which is purportedly mediated by the frontal cortex and its circuitry. Using incentive‐based auditory word recall and expository discourse tasks, we studied the efficiency of SL in children ages 6 to 16 years who had sustained severe traumatic brain injury (TBI) at least 1 year earlier. We hypothesized that SL would be compromised by severe TBI. Results indicated that children with severe TBI performed significantly worse than age‐matched typically developing children on word‐ and discourse‐level measures of SL efficiency with no significant group differences in number of items recalled from auditory word lists or declarative facts. We conclude that severe TBI disrupts incentive‐based cognitive control processes, possibly due to involvement of frontal neural networks. Ann Neurol 2004; 56: 847–853
Identity and Personality: The Big Five and Narrow Personality Traits in Relation to Sense of Identity

Based on a sample of 2,092 college students, Sense of Identity was found to be significantly related to the Big Five traits (Agreeableness, Conscientiousness, Emotional Stability, Extraversion, and Openness) as well as four narrow personality traits (Aggression, Optimism, Tough-Mindedness, and Work Drive). Results of multiple regression analyses indicated that after controlling for age, year in school, and sex, the Big Five traits accounted for 34% of the variance in Sense of Identity, with the narrow traits accounting for an additional 16% of the variance. A combination of six Big Five and narrow traits account for over 50% of the variance in Sense of Identity for the total sample as well as for demographic subgroups referenced by age, sex, ethnicity, marital status, family characteristics, transfer, and commuter status. It was suggested that personality traits may be influencing sense of identity. Results were discussed in terms of theoretical and methodological implications.
The effects of IT: from performance to value

Purpose – The purpose of this paper is to differentiate and define the concepts of firm performance and firm value. Then, the implications of information technology (IT)-enabled firm performance and firm value will be clarified. Finally, the effects of IT capabilities on firm performance and firm value will be compared. Design/methodology/approach – InformationWeek's IT leader rankings (from 1998 to 2011) are used for analysis in a longitudinal study. Three different test methods (i.e. significant years, significant levels, and adjusted-previous performance) are used. Findings – It is confirmed that no matter which tests are examined, the contributions of IT capabilities to firm value are all greater than those to firm performance. This also shows that IT contributes to long-term influences more than it does to short-term influences. Research limitations/implications – This study confirms that firm performance (accounting-based measures) and firm value (financial market-based measures) are two different v.
Generative Modeling with Conditional Autoencoders: Building an Integrated Cell

We present a conditional generative model to learn variation in cell and nuclear morphology and the location of subcellular structures from microscopy images. Our model generalizes to a wide range of subcellular localization and allows for a probabilistic interpretation of cell and nuclear morphology and structure localization from fluorescence images. We demonstrate the effectiveness of our approach by producing photo-realistic cell images using our generative model. The conditional nature of the model provides the ability to predict the localization of unobserved structures given cell and nuclear morphology.
Testing the links between emotional intelligence and motivation

Abstract The emotional intelligence construct is still the focus of substantial controversy. In this paper we contribute to the current debate regarding the factors that comprise the emotional intelligence construct. While some authors argue that emotional intelligence consists of a number of social and emotional competencies including self-motivation (Goleman 1995; 1998), others maintain emotional intelligence abilities are restricted to abilities that directly link emotions to cognition (Mayer & Salovey 1997). This latter view does not include motivation as a factor, but acknowledges it as a separate, related function. We conducted an empirical study to test these two different conceptualisations. One hundred and thirteen individuals completed measures of emotional intelligence and McClelland's (1987) three motivational needs. Structural equation analyses clearly supported Mayer and Salovey's (1997) conceptualisation that motivation is a factor related to emotional intelligence but is not a component part of the emotional intelligence construct. Implications are discussed.
Can special education make a difference? Exploring the differences of special educational systems between Finland and Norway in relation to the PISA results

This article discusses the differences in special educational systems in Finland and Norway in relation to the PISA scores. By comparing the Finnish system with the Norwegian, we have found that the strong focus both on early intervention and on reading and writing in Finland have positive effects on this country's PISA results. The situation in Norway is different, where there is less use of early intervention and a markedly weaker emphasis on reading and writing within special education. We discuss these differences in relation to these countries’ different cultural orientations with respect to education in general and to special education in particular.
Continuous flat-fading MIMO channels: achievable rate and optimal length of the training and data phases

In this paper, we propose a simple framework for evaluating the required repetition rate of channel estimation for multiple-input multiple-output (MIMO) systems in continuous slowly fading radio channels. An analytical formula for the interference due to the temporal variation of the channel coefficients is given and verified by link level simulations based on synthetic and measured impulse responses. The proposed interference model makes it possible to optimize the lengths of the training and data phases under different performance criteria. As an example, we investigate the bit-error rate performance of MIMO systems with zero-forcing detection and determine the time interval, after which the channel has to be estimated again in order to keep the error probability below a desired threshold. In the second part, the lengths of the training and data phases is optimized based on the information-theoretical capacity. It is shown that these lengths depend not only on the Doppler spread of the channel, but also on the antenna configuration and noise power.
Self-presentational efficacy: Does it moderate the relationship between social physique anxiety and physical activity in university students?

The relationship between social physique anxiety (SPA) and physical activity has been inconsistent, with studies showing positive, negative, and no relationship between them. The present study investigated whether self-presentational efficacy moderated the relationship between SPA and physical activity behaviour in university students, as it does in other samples. University students (208 women and 125 men) completed measures of SPE, trait SPA, and moderate-vigorous physical activity. Hierarchical moderated regression analysis showed no evidence of moderation. For women, both self-presentational efficacy expectancy (SPEE) and self-presentational outcome value positively predicted moderate-vigorous physical activity, with efficacy expectancy accounting for greater variance. For men, only SPEE was a significant predictor. It may be effective to increase SPEE in university students to encourage greater physical activity.
Incidence of fatal adverse drug reactions: a population based study.

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Although drugs generally are safe and effective therapies for numerous diseases, adverse drug reactions do occur and may even be fatal. * The incidence of fatal adverse drug reactions in hospitalized patients has been estimated to be approximately 5%. * In previous studies the incidence of fatal adverse drug reactions in hospitalized patients has been reported, but the incidence of fatal adverse drug reactions in the general population is largely unknown. WHAT THIS STUDY ADDS * Fatal adverse drug reactions account for approximately 3% of all deaths in the general population. * Haemorrhages amount to almost two-thirds of the fatal adverse drug reactions and antithrombotic agents are implicated in more than half of the suspected fatal adverse drug reactions. * Fatal adverse drug reactions are estimated to be the seventh most common cause of death in Sweden. AIMS To determine the incidence of fatal adverse drug reactions (FADRs) in a Swedish population. METHODS Every seventh randomly selected deceased in three counties in South-east Sweden during 1 January 2001-31 December 2001 was identified in the Cause of Death Register. Relevant case records (hospitals and/or primary care centres and medicolegal files) were reviewed to identify suspected drug-related fatalities. RESULTS Of 1574 deceased study subjects, 49 (3.1%; 95% CI 2.2%, 4.0%) were suspected to have died from FADRs. The most common suspected FADRs were gastrointestinal haemorrhages (n = 18; 37%), central nervous system haemorrhages (n = 14; 29%), cardiovascular disorders (n = 5; 10%), other haemorrhages (n = 4; 8%) and renal dysfunction (n = 3; 6%). The drugs most commonly implicated in FADRs were antithrombotic drugs (n = 31; 63%), followed by nonsteroidal anti-inflammatory drugs (NSAIDs) (n = 9; 18%), antidepressants (n = 7; 14%) and cardiovascular drugs (n = 4; 8%). Of all the 639 fatalities in hospital 41 (6.4%; 95% CI 4.5%, 8.3%) were suspected to be due to FADRs. CONCLUSIONS The medical burden of FADRs is significant. Haemorrhages were seen in a majority of the FADRs; antithrombotic agents or NSAIDs were implicated in most of these events. These results suggest that preventive measures should be taken to reduce the number of deaths caused by drugs.
Irritable Bowel Syndrome and Psychiatric Disorders in Pakistan: A Case Control Study

Background. The psychiatric disorders like anxiety and depression could have a profound influence on onset, expression, and course of Irritable bowel syndrome (IBS). Aim. To estimate the frequency and strength of association of common mental disorders (CMDs) in patients with IBS and patients with other chronic diseases, that is, migraine and hypertension. Method. This was a case control study. Individuals aged 18–70 years diagnosed as IBS were enrolled as cases. The control groups consisted of patients without IBS but diagnosed to have a chronic disease, that is, migraine or HTN. Self-Reporting Questonnaire-20(SRQ-20) was used as a screening tool for the detection of CMD. Results. 82 patients were enrolled in each group. Mean SRQ score was significantly higher in IBS group than controls (9.9 ± 4.5 versus 4.9 ± 3.6, P < 0.001). CMDs were more frequent (67.1% versus 22%) and the odds of CMD were 7.24 times higher among IBS patients than controls (95% CI 3.6–14.5, P < 0.001). No difference was found in frequency of CMDs among various subtypes of IBS. Conclusion. We found that CMDs are more common and strongly associated with IBS as compared to other chronic diseases. Early screening for CMDs might be useful for an effective management of IBS.