Miracle-dz/UniFAR-FTUs huggingface dataset:
A kinase interacting protein (AKIP1) is a key regulator of cardiac stress

Significance Early signaling events leading to protection in the heart under cardiac injury are poorly understood. We identified one such protein, A kinase interacting protein (AKIP1), as a modulator that responds to oxidative stress; up-regulation of AKIP1 showed protection to ischemic injury through enhanced mitochondrial integrity. We show AKIP1 functions as a molecular scaffold via interaction with mitochondrial apoptosis inducing factor and increases protein kinase A activity. These mitochondrial signaling complexes assembled by AKIP1 alter the physiological response of the heart under ischemic stress. Understanding molecular activity and regulation of AKIP1 could lead to novel therapeutic approaches to limit myocardial injury. cAMP-dependent protein kinase (PKA) regulates a myriad of functions in the heart, including cardiac contractility, myocardial metabolism, and gene expression. However, a molecular integrator of the PKA response in the heart is unknown. Here, we show that the PKA adaptor A-kinase interacting protein 1 (AKIP1) is up-regulated in cardiac myocytes in response to oxidant stress. Mice with cardiac gene transfer of AKIP1 have enhanced protection to ischemic stress. We hypothesized that this adaptation to stress was mitochondrial-dependent. AKIP1 interacted with the mitochondrial localized apoptosis inducing factor (AIF) under both normal and oxidant stress. When cardiac myocytes or whole hearts are exposed to oxidant and ischemic stress, levels of both AKIP1 and AIF were enhanced. AKIP1 is preferentially localized to interfibrillary mitochondria and up-regulated in this cardiac mitochondrial subpopulation on ischemic injury. Mitochondria isolated from AKIP1 gene-transferred hearts showed increased mitochondrial localization of AKIP1, decreased reactive oxygen species generation, enhanced calcium tolerance, decreased mitochondrial cytochrome C release, and enhance phosphorylation of mitochondrial PKA substrates on ischemic stress. These observations highlight AKIP1 as a critical molecular regulator and a therapeutic control point for stress adaptation in the heart.
“Liar, Liar Pants on Fire”: A New Benchmark Dataset for Fake News Detection

Automatic fake news detection is a challenging problem in deception detection, and it has tremendous real-world political and social impacts. However, statistical approaches to combating fake news has been dramatically limited by the lack of labeled benchmark datasets. In this paper, we present LIAR: a new, publicly available dataset for fake news detection. We collected a decade-long, 12.8K manually labeled short statements in various contexts from PolitiFact.com, which provides detailed analysis report and links to source documents for each case. This dataset can be used for fact-checking research as well. Notably, this new dataset is an order of magnitude larger than previously largest public fake news datasets of similar type. Empirically, we investigate automatic fake news detection based on surface-level linguistic patterns. We have designed a novel, hybrid convolutional neural network to integrate meta-data with text. We show that this hybrid approach can improve a text-only deep learning model.
The Importance of Trade Costs in Deviations from the Law‐of‐One‐Price: Estimates Based on the Direction of Trade

The full impact of trade costs in segmenting product markets cannot be captured by considering aggregate prices or in the absence of information on the direction of trade. We address this problem by utilizing product‐specific prices, cross‐sectional productivity indices, and bilateral trade flows, allowing us to identify the probable source of any one product. We show that trade costs in the form of transportation and distribution costs are important in determining international price differences and segmenting international markets. Physical distance relative to the origin has a precisely estimated positive impact on international deviations from the Law‐of‐One‐Price that is larger than estimates that do not account for the origin of each product. Based on our benchmark estimates, the price elasticity of distance was around 10% in 1990.
An Empirical Study: To What Extent and In What Ways Does Social Foundations of Education Inform Four Teachers’ Educational Beliefs and Classroom Practices?

Within the state selected for this study, teacher preparation programs and state certification criterion require that educators examine the relationship between school and society within social foundations of education (SFE) coursework. Using observations and interviews, this study examines to what extent four experienced, urban classroom teachers both speak in belief and exhibit in classroom practice an understanding of SFE. Two sets of measures, rooted in the social foundations and curriculum traditions, were devised to examine the degree to which teachers’ beliefs and practices matched to the tenets of SFE. Inconsistencies were evident within each teacher's beliefs and practices. Also, among the four respondents, there was minimal uniformity. From this study, when teaching even with a limited understanding of SFE, instructors engendered practices essential for a democracy. Students composed critical works, combining academic content as well as skills essential for life in a self-representative government. Use of these particular measures could be applied to inform pre-service teacher education programs as well as professional, in-service development.
Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica

Intractable hiccup and nausea (IHN) was found in eight of 47 cases of relapsing neuromyelitis optica (NMO) (17%) but in none of 130 cases of multiple sclerosis (MS). IHN resolved with methylprednisolone. In six cases, MRI detected linear medullary lesions involving the pericanal region, the area postrema, and the nucleus tractus solitarius. Like long and centrally located myelitis, a linear medullary lesion causing IHN may distinguish NMO from MS.
Is implicational generalization unidirectional and maximal? Evidence from relativization instruction in a second language

L'A. teste l'hypothese de la generalisation implicationnelle (effet d'une instruction formelle) chez des sujets adultes apprenant l'anglais langue seconde. L'experimentation est basee sur les niveaux de hierarchie d'accessibilite des syntagmes nominaux de Keenan et Comrie (1977). L'A. degage quelques consequences pour la pedagogie en langue seconde
Compressing and indexing labeled trees, with applications

Consider an ordered, static tree T where each node has a label from alphabet Σ. Tree T may be of arbitrary degree and shape. Our goal is designing a compressed storage scheme of T that supports basic navigational operations among the immediate neighbors of a node (i.e. parent, ith child, or any child with some label,…) as well as more sophisticated path-based search operations over its labeled structure. We present a novel approach to this problem by designing what we call the XBW-transform of the tree in the spirit of the well-known Burrows-Wheeler transform for strings [1994]. The XBW-transform uses path-sorting to linearize the labeled tree T into two coordinated arrays, one capturing the structure and the other the labels. For the first time, by using the properties of the XBW-transform, our compressed indexes go beyond the information-theoretic lower bound, and support navigational and path-search operations over labeled trees within (near-)optimal time bounds and entropy-bounded space. Our XBW-transform is simple and likely to spur new results in the theory of tree compression and indexing, as well as interesting application contexts. As an example, we use the XBW-transform to design and implement a compressed index for XML documents whose compression ratio is significantly better than the one achievable by state-of-the-art tools, and its query time performance is order of magnitudes faster.
Job Satisfaction among Working Women

The extent of job satisfaction among women is an important aspect of their labor market experience, for it may signify the degree to which they have made a successful accommodation to the world of work. The issue is especially important in the case of women in their thirties and forties, because the children of those in this age group are generally of school age, and decreasing home responsibilities allow considerable reentry into the work force. However, successful accommodation to the work force may be inhibited by special labor market problems that frequently confront such women: conflicting responsibilities at home and at work, obsolescence of skills, readjustment problems occasioned by long absences from the work force, or sex discrimination by employers. A clearer understanding of the forces that shape the job satisfaction of these women promises a better insight into the process of labor market accommodation among women, particularly as they reenter the work force. Such insight should help policymakers to design strategies to make social and economic institutions serve the needs of working women better. In addition to their value for the welfare of individuals, such policies are useful to employers and society as a whole. '
Ethnic match and client ethnicity effects on global assessment and visitation

The effects of client-therapist ethnic match and client ethnicity on therapist-evaluated Global Assessment of Function (GAF) and visitation were investigated. The sample consisted of several thousand outpatient clients of a Southern California community mental health center. Findings indicated that unadjusted GAF-intake and GAF-termination scores were higher for ethnically matched Latino and Asian Americans but not for African and White Americans. Unadjusted GAF-difference scores for ethnically matched Latino and White Americans were higher than for African American clients. Unadjusted visitation or total visits was lower for ethnically matched Asian and Latino American clients, while African and White American clients had relatively high visitation levels regardless of the ethnic match status. After adjusting for 12 other variables, ethnically matched Asian American therapists consistently evaluated clients higher than did ethnically matched African American therapists. Adjusted visitation revealed fewer total visits for ethnically matched Latino and African American clients, while White Americans garnered higher visit levels when ethnically matched, and Asian Americans evidenced relatively high levels of visitation regardless of ethnic match status. Separate diagnostic category analyses revealed higher GAF-termination scores for ethnically matched African, Asian, and Latino American (schizophrenic) clients and ethnically matched Latino and Asian(mood disorder) clients. Implications for future research are discussed. © 2000 John Wiley & Sons, Inc.
Implicit sexual interest in children: does separating gender influence discrimination when using the Implicit Association Test?

Abstract The current study examined the discriminative and convergent validity of three Implicit Association Test (IAT) measures designed to assess sexual interest in girls, in boys or in children. Sex offenders against children (n =29) did not differ from non-sex offenders (n=28) on these IAT measures. The IAT measures were related to a physiological measure of sexual interest in children, but not to a file-based measure of sexual interest in children or the sexual preference item of the STABLE-2007. The relationship between the IAT measures and risk scales designed to predict sexual recidivism was counter-intuitive. Greater sexual interest in boys, as assessed by the IAT measure, was related to lower risk of sexual recidivism. The current study did not provide compelling evidence for the validity of IAT measures designed to assess sexual interest in children. A better understanding of construct validity of IAT measures is needed before their use in the assessment and management of sexual offenders against children.
Presurgical Language Mapping

Neurosurgical procedures for tumors or intractable epilepsy are often accompanied by risk to postoperative cognitive function; surgery in the left temporal or frontal lobes, for example, can place language functions at risk. Hence, prior to tissue extraction, one common surgical goal is to attempt to identify frontal and temporal regions that should be spared in order to preserve language function. We describe how basic research on false memory for word lists has led to a novel approach for identifying such language-related regions in healthy controls. That is, rapid presentation of semantically related words (e.g., bed, rest, awake) and phonologically related words (e.g., peep, weep, heap) with instructions to attend to relations among the words elicits activity in underlying language networks. Furthermore, it is often possible to identify the neural underpinnings of these networks in an individual person in about an hour of functional magnetic resonance imaging (fMRI) scanning. We conclude by suggesting directions for future research with this lexical-processing protocol, the overarching goal being to link basic cognitive science and clinical practice.
Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype. We developed a computational model of glycolysis and an integrated analysis using metabolic control analysis (MCA), metabolomics data, and statistical simulations. We identified and confirmed a novel mode of regulation specific to aerobic glycolysis where flux through GAPDH, the enzyme separating lower and upper glycolysis, is the rate-limiting step in the pathway and the levels of fructose (1,6) bisphosphate (FBP), are predictive of the rate and control points in glycolysis. Strikingly, negative flux control was found and confirmed for several steps thought to be rate-limiting in glycolysis. Together, these findings enumerate the biochemical determinants of the WE and suggest strategies for identifying the contexts in which agents that target glycolysis might be most effective. DOI: http://dx.doi. org/10.7554/eLife.03342. 001
Tracking the sea‐level signature of the 8.2 ka cooling event: New constraints from the Mississippi Delta

The ever increasing need for accurate predictions of global environmental change under greenhouse conditions has sparked immense interest in an abrupt, century‐scale cooling around 8200 years ago, with a focal point in the North Atlantic and with hemispheric teleconnections. Despite considerable progress in the unraveling of this striking feature, including a conceivable driving mechanism (rapid drainage of proglacial Lake Agassiz/Ojibway and a resulting reduced strength of North Atlantic thermohaline circulation), several key questions remain unanswered. One salient aspect concerns the total amount of freshwater released during this catastrophic event, likely echoed by a near‐instantaneous eustatic sea‐level rise. So far, no attempts have been made to perform high‐resolution sea‐level studies that explicitly focus on this critical time interval. Here, we present new data from the Mississippi Delta suggestive of abrupt sea‐level rise associated with the 8.2 ka event. However, the amount of sea‐level rise was likely less than ∼1.2 m, corresponding to a meltwater volume of less than ∼4.3 1014 m3; values lower than estimates used by several recent studies.
Antecedents of Organizational Citizenship Behavior: The Mediating Role of Leader-member Exchange

본 연구는 조직시민행동의 선행요인을 찾고, 그리고 LMX(leader-member exchange)의 매개역할을 살펴보는 것이다. 선행연구 검토를 통해 본 연구는 조직시민행동과 LMX에 영향을 미치는 요인을 개인(분배, 절차 공정성), 그룹(변혁적 리더십, 팀 임파워먼트), 그리고 조직(조직구조의 복잡성)수준으로 분류하였다. 산업단지 공단에 근무하는 종업원들을 대상으로 설문조사를 실시하였고, 총 773부의 설문지가 실증분석에 사용되었다. 실증분석 결과, 절차적 공정성, 변혁적 리더십, 그리고 팀 임파워먼트가 조직시민행동에 정(+)의 영향을 미치는 것으로 나타났다. 또한 분배공정성, 절차공정성, 변혁적 리더십, 팀 임파워먼트, 조직구조의 복잡성은 LMX에 정(+)의 영향을 미치는 것으로 나타났다. 게다가 LMX는 5개의 독립변수(분배공정성, 절차공정성, 변혁적 리더십, 팀 임파워먼트, 조직구조의 복잡성)가 조직시민행동에 미치는 영향관계에서 매개역할을 하는 것으로 나타났다. 연구결과를 바탕으로 연구의 시사점과 한계점 등에 대해서도 논의하였다. 【The main purpose of this study was to find antecedents of organizational citizenship behavior(OCB) and to investigate the mediating role of leader-member exchange(LMX). This study categorized the factors that influence OCB and LMX into individual(distributive and procedural justice), group(transformational leadership and team empowerment), and organizational levels(complexity). A total of 773 cases were used in this study, which were collected in one of industrial complexes. The research participants were any employees who participated in their work by collaborating with their co-workers. This study found that procedural justice, transformational leadership, and team empowerment had positive influences on OCB, and distributive justice, procedural justice, transformational leadership, team empowerment, and complexity significantly influenced LMX. Moreover, LMX played a mediating role in the relationship between each of the five input variables and OCB. 】
Disclosure via website corporativo: um exame de informações financeiras e de governança no mercado brasileiro

Este artigo objetiva analisar a relacao entre a disseminacao voluntaria de informacoes relevantes nos websites de empresas abertas com suas caracteristicas, tendo como amostra 282 empresas nao financeiras listadas na Bovespa. Com base na relevância de informacoes corporativas (financeira e de governanca) avaliadas pelos intermediarios de informacoes, que embasaram a constituicao de indices ponderados de disclosure, os resultados sugerem que ha maior disclosure: i) quanto maior a firma e quanto maior o retorno das acoes da empresa; ii) em empresas de governanca corporativa diferenciada; iii) em categorias de informacoes corporativas mais requeridas pelas agencias de rating e pelas corretoras; iv) em empresas mais endividadas.
Blind separation of audio sources using modal decomposition

This paper introduces new algorithms for the blind separation of audio sources using modal decomposition. Indeed, audio signals and, in particular, musical signals can be well approximated by a sum of damped sinusoidal (modal) components. Based on this representation, we propose a two steps approach consisting of a signal analysis (extraction of the modal components) followed by a signal synthesis (pairing of the components belonging to the same source) using vector clustering. For the signal analysis, two algorithms are considered and compared: namely the EMD (Empirical Mode Decomposition) algorithm and a parametric estimation algorithm using ESPRIT technique. A major advantage of the proposed method resides in its ability to separate more sources than sensors. Simulation results are given to compare and assess the performances of the proposed algorithms.
Organizing practices of reflection: A practice-based study

This article extends debates of how organizing practices of reflexivity and collective mindfulness are encouraged and sustained for learning, critique and change. We present, in a practice-based study, a fourfold framework of anticipatory, deliberative, organizing and critically reflexive practices. Our empirical study illustrates how these multiple forms of reflexive practice can support and co-shape one another so that knowing what to do next emerges in the midst of practice. Our analysis demonstrates the value of going beyond the optical metaphor of reflection to that of critical reflexivity and the metaphor of diffraction. This approach extends understandings of reflective practice in ways that foreground entanglement, co-production and the relational qualities of practice. Diffraction encourages managers and practitioners to not only reflect on what has been done but to also map the effects of their practices and interventions. This orientation assists them to notice the impact of their actions and better understand the complexities of organized reflection-in-action.
Endoscopic stenting for malignant biliary obstruction.

OBJECTIVE To evaluate the results of endoscopic stenting in patients with malignant biliary obstruction. DESIGN Retrospective review. SETTING Surgical endoscopy unit at a tertiary referral center. PATIENTS AND INTERVENTION Plastic endoprosthetic stents were inserted for the relief of biliary obstruction in 131 consecutive patients. Among the 104 patients with malignant biliary obstruction, 60 underwent stenting as definitive palliative treatment. MAIN OUTCOME MEASURES Data on the type and size of stents employed, their effectiveness in relieving jaundice, their complications, and the quality of survival were analyzed. RESULTS Median survival was 1.93 months. The majority of the stents (88.3%) were placed endoscopically, and single straight stents were most frequently used (96.7%). Jaundice was relieved in 35 patients. Early (< or = 14 days) and late acute cholangitis were found in four and 11 patients, respectively. Early and late stent migration was noticed in two and six patients, respectively. Pancreatitis occurred in one patient, and no papillotomy site bleeding was encountered. When compared with the 18 patients with proximal obstruction at or above the common hepatic duct, the 42 patients with distal ductal obstruction had longer median survival (P = .03) and more effective relief of jaundice (P = .005) and required less antibiotic treatment (P = .03). These 42 patients also enjoyed better quality of survival when it was analyzed with reference to six objective parameters (P = .0018). CONCLUSIONS Stenting offers palliation of malignant biliary obstruction, and the results are particularly encouraging in distal obstruction.
Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity

The development of neural circuits relies on spontaneous electrical activity that occurs during immature stages of development. In the developing mammalian auditory system, spontaneous calcium action potentials are generated by inner hair cells (IHCs), which form the primary sensory synapse. It remains unknown whether this electrical activity is required for the functional maturation of the auditory system. We found that sensory-independent electrical activity controls synaptic maturation in IHCs. We used a mouse model in which the potassium channel SK2 is normally overexpressed, but can be modulated in vivo using doxycycline. SK2 overexpression affected the frequency and duration of spontaneous action potentials, which prevented the development of the Ca2+-sensitivity of vesicle fusion at IHC ribbon synapses, without affecting their morphology or general cell development. By manipulating the in vivo expression of SK2 channels, we identified the “critical period” during which spiking activity influences IHC synaptic maturation. Here we provide direct evidence that IHC development depends upon a specific temporal pattern of calcium spikes before sound-driven neuronal activity.