Miracle-dz/UniFAR-FTUs huggingface dataset:
Subjective cognitive impairment

Purpose of review To describe the recent (2011–2012) literature relevant to subjective cognitive impairment (SCI), focusing principally on studies of this symptom in older age groups. This is an issue of growing importance: although the symptom itself is controversial in older people because of variable associations with objective cognitive impairment, it remains one of the few presenting complaints which may identify people experiencing early cognitive decline. Recent findings Several neuroimaging studies confirm earlier reports of associations between SCI and underlying abnormalities whereas those between subjective and objective cognitive function remain heterogeneous. Several studies now highlight the fact that, regardless of underlying associations, SCI as a symptom is associated with significant concern but is something for which older people rarely seek help. Summary Neuroimaging findings suggest that older people may be more aware of underlying brain changes than was previously apparent or than can be detected using conventional neuropsychological assessments. However, not all of these brain changes are necessarily progressive or neurodegenerative. At least some attention should be paid to interventions for what is a common, often distressing, but underreported symptom.
[Studies on the flavonoids from the flowers of Hylocereus undatus].

OBJECTIVE To study the chemical constituents of the flowers of Hylocereus undatus. METHODS The constituents were isolated and purified by various modern chromatographic techniques. The structures of the compounds were elucidated based on their physicochemical properties and spectral analyses. RESULTS Thirteen compounds were isolated from the flowers of H. undatus. Their structures were elucidated as kaempferol (1), quercetin (2), isorhamnetin (3), kaempferol 3-O-alpha-L-arabinfuranoside (4), kaempferol 3-O-beta-D-glucopyranoside (5), quercetin 3-O-beta-D-glucopyranoside (6), isorhamnetin 3-O-beta-D-glucopyranoside (7), kaempferol 3-O-beta-D-galactopyranoside (8), quercetin 3-O-beta-D-galactopyranoside (9), kaempferol 3-O-beta-D-rutinoside (10), isorhamnetin 3-O-beta-D-rutinoside (11), kaempferol 3-O-alpha-L-rhamopyranosyl-(1 --> 6)-beta-D-galactopyranoside (12), and isorhamnetin 3-O-alpha-L-rhamopyranosyl-(1 --> 6)-beta-D-galactopyranoside (13). CONCLUSION All the compounds are isolated from this plant for the first time.
Resilience: one part recovery, two parts sustainability.

The collection of papers in this issue of Journal of Personality is among the best in the field to date. The papers offer a clear window into the developing science of resilience and invite us to develop our own inquiries about how individuals, families, groups, and even communities can be resilient. In this commentary my intent is to provide a framework for the papers presented in this issue, highlight contributions the authors make to this emerging field of inquiry, and challenge the reader to think both critically and creatively about new directions they would like the field to take. To begin, allow me to offer a two-part definition of the resilience domain that I believe is broad enough to encompass diverse ways the term is used not only in this special issue but also throughout the biopsychosocial sciences. In my view, inquiries about resilience, whether posed by social scientists, therapists, individuals or communities address two fundamental questions about adaptation (Zautra, Hall, & Murray, 2008). One part of this domain concerns recovery, that is, how quickly people bounce back and recover fully from challenging events (Masten, 2001; Rutter, 1987). By people I mean individuals but also families, communities, and other collectivities. People who are resilient display a greater capacity to quickly regain equilibrium physiologically, psychologically, and in their social relations following stressful events.
The Effect of Using Mobile Technology-Based Methods That Record Food or Nutrient Intake on Diabetes Control and Nutrition Outcomes: A Systematic Review

(1) Background: Mobile technologies may be utilised for dietary intake assessment for people with diabetes. The published literature was systematically reviewed to determine the effect of using mobile electronic devices to record food or nutrient intake on diabetes control and nutrition outcomes; (2) Methods: The review protocol was registered with PROSPERO: registration number CRD42016050079, and followed PRISMA guidelines. Original research of mobile electronic devices where food or nutrient intake was recorded in people with diabetes with any treatment regimen, and where this intervention was compared with usual care or alternative treatment models, was considered. Quality was assessed using the Quality Criteria Checklist for Primary Research; (3) Results: Nine papers formed the final library with a range of interventions and control practices investigated. The food/nutrient intake recording component of the intervention and patient engagement with the technology was not well described. When assessed for quality, three studies rated positive, five were neutral and one negative. There was significantly greater improvement in HbA1c in the intervention group compared to the control group in four of the nine studies; (4) Conclusion: Based on the available evidence there are no clear recommendations for using technology to record dietary data in this population.
Severe Hypomyelination of the Murine CNS in the Absence of Myelin-Associated Glycoprotein and Fyn Tyrosine Kinase

The analysis of mice deficient in the myelin-associated glycoprotein (MAG) or Fyn, a nonreceptor-type tyrosine kinase proposed to act as a signaling molecule downstream of MAG, has revealed that both molecules are involved in the initiation of myelination. To obtain more insights into the role of the MAG–Fyn signaling pathway during initiation of myelination and formation of morphologically intact myelin sheaths, we have analyzed optic nerves of MAG-, Fyn- and MAG/Fyn-deficient mice. We observed a slight hypomyelination in optic nerves of MAG mutants that was significantly increased in Fyn mutants and massive in MAG/Fyn double mutants. The severe morphological phenotype of MAG/Fyn mutants, accompanied by behavioral deficits, substantiates the importance of both molecules for the initiation of myelination. The different severity of the phenotype of different genotypes indicates that the MAG–Fyn signaling pathway is complex and suggests the presence of compensatory mechanisms in the single mutants. However, data are also compatible with the possibility that MAG and Fyn act independently to initiate myelination. Hypomyelination of optic nerves was not related to a loss of oligodendrocytes, indicating that the phenotype results from impaired interactions between oligodendrocyte processes and axons and/or impaired morphological maturation of oligodendrocytes. Finally, we demonstrate that Fyn, unlike MAG, is not involved in the formation of ultrastructurally intact myelin sheaths.
Phylogenomics insights into order and families of Lysobacterales

Order Lysobacterales (earlier known Xanthomonadales ) is a taxonomically complex group of a large number of gamma-proteobacteria classified in two different families, namely Lysobacteraceae and Rhodanobacteraceae . Current taxonomy is largely based on classical approaches and is devoid of whole-genome information-based analysis. In the present study, we have taken all classified and poorly described species belonging to the order Lysobacterales to perform a phylogenetic analysis based on the 16 S rRNA sequence. Moreover, to obtain robust phylogeny, we have generated whole-genome sequencing data of six type species namely Metallibacterium scheffleri , Panacagrimonas perspica , Thermomonas haemolytica , Fulvimonas soli , Pseudofulvimonas gallinarii and Rhodanobacter lindaniclasticus of the families Lysobacteraceae and Rhodanobacteraceae . Interestingly, whole-genome-based phylogenetic analysis revealed unusual positioning of the type species Pseudofulvimonas , Panacagrimonas , Metallibacterium and Aquimonas at family level. Whole-genome-based phylogeny involving 92 type strains resolved the taxonomic positioning by reshuffling the genus across families Lysobacteraceae and Rhodanobacteraceae . The present study reveals the need and scope for genome-based phylogenetic and comparative studies in order to address relationships of genera and species of order Lysobacterales .
Pattern of stroke in a rural Kenyan hospital

Background The pattern of stroke in rural population differs from that in urban ones. Although there are many studies on this condition in sub-Saharan Africa, few studies about stroke pattern in a Kenyan rural area exist. This study therefore aims at describing the characteristics of stroke in a rural Kenyan hospital. Patients and Methods The study was conducted on 227 consecutive patients admitted with a World Health Organization (WHO) diagnosis of stroke in Kangundo Hospital, a level IV facility in Machakos, Eastern Kenya, between April 2015 and September 2016. The sub-type and anatomical distribution of stroke as well as the age, gender of the patients were recorded prospectively. Diagnosis was made through physical neurological examination and confirmed by Computerized Tomography (CT) scan imaging. Only those with complete bio-data, past medical and social history, clinical and physical findings of the patients and imaging results were included. The data were entered into a pre-formatted questionnaire, analysed for means, standard deviations and frequencies, and are presented in tables and bar charts. Results Out of 3200 medical admissions, 227 (7.09%) had a confirmed diagnosis of stroke. Ischaemic stroke was more common (67.4%) than haemorrhagic stroke (32.6%). It affected mainly the anterior circulation, especially the middle cerebral artery (39%). The mean age of patients was 68.8 years, (Range 32–96). It was more common in females (62%) than in males (38%). Hypertension was the most common (74%) risk factor followed by alcohol abuse (63%), tobacco smoking (48%) and diabetes mellitus (42%). Conclusion Ischaemic stroke was the more common major cause of morbidity in the rural hospital studied in Kenya. It occurred most commonly among elderly females, with the most frequent comorbidities being hypertension. In addition, modifiable lifestyle factors like alcohol abuse and cigarette smoking contributed to the prevalence; hence we recommend the control of blood pressure and glucose as well as lifestyle modification to reduce the scourge in our studied population.
Stimulation of macrophage phagocytic but not bactericidal activity by colony-stimulating factor 1

The ability of mouse peritoneal cells to phagocytose and lyse Listeria monocytogenes was measured after the cells were incubated with purified murine macrophage-specific colony-stimulating factor (CSF-1). Activation of combined phagocytic and bacteriolytic ability required 24 h, with an optimal dose of 1,000 U of CSF-1 per ml. No activation was achieved with a shorter period of incubation, known to be sufficient for GM-CSF to stimulate phagocytosis by granulocytes, and there was no advantage in longer exposure. After 24 h in 1,000 U of CSF-1, macrophages showed visibly increased spreading on the plastic petri dish. Activated cells examined microscopically showed an increase in the number of phagocytic cells and in the numbers of bacteria per phagocytic cell. This increased phagocytic ability was evident also in the increase in the amount of radioactivity associated with the cells following a 30-min incubation with radiolabeled bacteria. When these cells were carefully washed, the percentage of this initial uptake released during the next 2 h was not increased by pretreatment of the cells with CSF-1, showing that the effect of this growth factor was on phagocytosis of the bacteria not on the killing mechanisms per se.
Ten Years of the Collaborative Cross

The February 2012 issues of GENETICS and G3: Genes, Genomes, Genetics present a collection of articles reporting recent advances from the international Collaborative Cross (CC) project. The goal of the CC project is to develop a new resource that will enhance quantitative trait locus (QTL) and systems genetic analyses in mice. The CC consists of hundreds of independently bred, octo-parental recombinant inbred lines (Figure 1). The work reported in these issues represents progress toward completion of the CC, proof-of-principle experiments using incipient inbred CC mice, and new research areas and complementary resources facilitated by the CC project.
The Oxidative DNA Lesion 8,5′-(S)-Cyclo-2′-deoxyadenosine Is Repaired by the Nucleotide Excision Repair Pathway and Blocks Gene Expression in Mammalian Cells*

Xeroderma pigmentosum (XP) patients with inherited defects in nucleotide excision repair (NER) are unable to excise from their DNA bulky photoproducts induced by UV radiation and therefore develop accelerated actinic damage, including cancer, on sun-exposed tissue. Some XP patients also develop a characteristic neurodegeneration believed to result from their inability to repair neuronal DNA damaged by endogenous metabolites since the harmful UV radiation in sunlight does not reach neurons. Free radicals, which are abundant in neurons, induce DNA lesions that, if unrepaired, might cause the XP neurodegeneration. Searching for such a lesion, we developed a synthesis for 8,5′-(S)-cyclo-2′-deoxyadenosine (cyclo-dA), a free radical-induced bulky lesion, and incorporated it into DNA to test its repair in mammalian cell extracts and living cells. Using extracts of normal and mutant Chinese hamster ovary (CHO) cells to test for NER and adult rat brain extracts to test for base excision repair, we found that cyclo-dA is repaired by NER and not by base excision repair. We measured host cell reactivation, which reflects a cell's capacity for NER, by transfecting CHO and XP cells with DNA constructs containing a single cyclo-dA or a cyclobutane thymine dimer at a specific site on the transcribed strand of a luciferase reporter gene. We found that, like the cyclobutane thymine dimer, cyclo-dA is a strong block to gene expression in CHO and human cells. Cyclo-dA was repaired extremely poorly in NER-deficient CHO cells and in cells from patients in XP complementation group A with neurodegeneration. Based on these findings, we propose that cyclo-dA is a candidate for an endogenous DNA lesion that might contribute to neurodegeneration in XP.
Blind Interference Alignment for a Class of K-user Line-of-Sight Interference Channels

We consider a class of K-user line-of-sight interference channels without channel state information at transmitters (CSIT). All transmitters are fixed while receiver i has high mobility if i∈{1,2,⋯,K1} and has low mobility otherwise, where K-1≤ K1≤ K, and the channel coherence times for high- and low-mobility receivers are given by one and T, respectively. In addition, we assume that both transmitter i and receiver i use M≥ T antennas if i∈{1,2,⋯K1} and use only one antenna otherwise. In this paper, we propose an interference alignment (IA) scheme for these channels. The key idea is to group receivers with different mobility to have different coherence time. The results show that IA can improve the degrees of freedom even in the absence of CSIT under certain conditions.
Childhood Precursors of Adult Borderline Personality Disorder Features: A Longitudinal Study

Abstract This study identifies childhood personality traits that are precursors of adult Borderline Personality Disorder (BPD) features. In a longitudinal study, childhood personality traits were assessed at age 11 (N = 100) using the California Child Q-set (CCQ: Block and Block, 1980). A number of these Q-items were found to be significantly correlated (p < 0.001) with a prototype-based measure of BPD features at age 23. Factor analysis of these Q-items suggested that they could be characterized by two underlying personality dimensions: Impulsivity and Nonconformity/Aggression. The findings thus provide evidence that childhood personality traits predict adult BPD features. Identifying such childhood precursors provides an opportunity for early intervention.
Completions, Coordination, and Alignment in Dialogue

Collaborative completions are among the strongest evidence that dialogue requires coordination even at the sub-sentential level; the study of sentence completions may thus shed light on a number of central issues both at the `macro’ level of dialogue management and at the `micro’ level of the semantic interpretation of utterances. We propose a treatment of collaborative completions in PTT, a theory of interpretation in dialogue that provides some of the necessary ingredients for a formal account of completions at the ‘micro’ level, such a theory of incremental utterance interpretation and an account of grounding. We argue that an account of semantic interpretation in completions can be provided through relatively straightforward generalizations of existing theories of syntax such as Lexical Tree Adjoining Grammar (LTAG) and of semantics such as (Compositional) DRT and Situation Semantics. At the macro level, we provide an intentional account of completions, as well as a preliminary account within Pickering and Garrod’s alignment theory.
Race Is Not Neutral: A National Investigation of African American and Latino Disproportionality in School Discipline

Abstract. Discipline practices in schools affect the social quality of each educational environment, and the ability of children to achieve the academic and social gains essential for success in a 21st century society. We review the documented patterns of office discipline referrals in 364 elementary and middle schools during the 2005–2006 academic year. Data were reported by school personnel through daily or weekly uploading of office discipline referrals using the Web-based School-wide Information System. Descriptive and logistic regression analyses indicate that students from African American families are 2.19 (elementary) to 3.78 (middle) times as likely to be referred to the office for problem behavior as their White peers. In addition, the results indicate that students from African American and Latino families are more likely than their White peers to receive expulsion or out of school suspension as consequences for the same or similar problem behavior. These results extend and are consistent with a long history of similar findings, and argue for direct efforts in policy, practice, and research to address ubiquitous racial and ethnic disparities in school discipline.
Regulation of Eosinophil Trafficking by SWAP-70 and Its Role in Allergic Airway Inflammation

Eosinophils are the predominant inflammatory cells recruited to allergic airways. In this article, we show that human and murine eosinophils express SWAP-70, an intracellular RAC-binding signaling protein, and examine its role in mediating eosinophil trafficking and pulmonary recruitment in a murine model of allergic airway inflammation. Compared with wild-type eosinophils, SWAP-70–deficient (Swap-70−/−) eosinophils revealed altered adhesive interactions within inflamed postcapillary venules under conditions of blood flow by intravital microscopy, exhibiting enhanced slow rolling but decreased firm adhesion. In static adhesion assays, Swap-70−/− eosinophils adhered poorly to VCAM-1 and ICAM-1 and exhibited inefficient leading edge and uropod formation. Adherent Swap-70−/− eosinophils failed to translocate RAC1 to leading edges and displayed aberrant cell surface localization/distribution of α4 and Mac-1. Chemokine-induced migration of Swap-70−/− eosinophils was significantly decreased, correlating with reduced intracellular calcium levels, defective actin polymerization/depolymerization, and altered cytoskeletal rearrangement. In vivo, recruitment of eosinophils to the lungs of allergen-challenged Swap-70−/− mice, compared with wild-type mice, was significantly reduced, along with considerable attenuation of airway inflammation, indicated by diminished IL-5, IL-13, and TNF-α levels; reduced mucus secretion; and improved airway function. These findings suggest that regulation of eosinophil trafficking and migration by SWAP-70 is important for the development of eosinophilic inflammation after allergen exposure.
Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

Immunoglobulin (Ig)M+IgD+ B cells are generally assumed to represent antigen-inexperienced, naive B cells expressing variable (V) region genes without somatic mutations. We report here that human IgM+IgD+ peripheral blood (PB) B cells expressing the CD27 cell surface antigen carry mutated V genes, in contrast to CD27-negative IgM+IgD+ B cells. IgM+IgD+CD27+ B cells resemble class-switched and IgM-only memory cells in terms of cell phenotype, and comprise ∼15% of PB B lymphocytes in healthy adults. Moreover, a very small population (<1% of PB B cells) of highly mutated IgD-only B cells was detected, which likely represent the PB counterpart of IgD-only tonsillar germinal center and plasma cells. Overall, the B cell pool in the PB of adults consists of ∼40% mutated memory B cells and 60% unmutated, naive IgD+CD27− B cells (including CD5+ B cells). In the somatically mutated B cells, VH region genes carry a two- to threefold higher load of somatic mutation than rearranged Vκ genes. This might be due to an intrinsically lower mutation rate in κ light chain genes compared with heavy chain genes and/or result from κ light chain gene rearrangements in GC B cells. A common feature of the somatically mutated B cell subsets is the expression of the CD27 cell surface antigen which therefore may represent a general marker for memory B cells in humans.
Aetiology of Spontaneous Intracerebral Haemorrhage in Young Adults Admitted at a Tertiary Care Hospital in Dhaka

Spontaneous Intracerebral Haemorrhage (SICH) in young adult occurs due to multiple risk factors. The purpose of the present study was to determine the aetiological factors of spontaneous intracerebral haemorrhage in the young adult patients. This case control study was carried out in the Department of Neurology, Department of Neurosurgery and Department of Internal Medicine at Dhaka Medical College Hospital, Dhaka from September 2010 to August 2011 for a period of one (01) year. Patients aged 15 to 45 years who presented with spontaneous intracerebral haemorrhage were taken as case (Group A) and those more than 45 years of age with spontaneous intracerebral haemorrhage were taken as control (Group B). All the aetiological factors were recorded in a predesigned data sheet. A total of 430 patients with clinical feature of stroke were admitted through emergency and outpatient department during the study period, of which 152(35.34%) patients had spontaneous intracerebral haemorrhage. Based on the inclusion and exclusion criteria 35 patients were recruited from 15-45 years age range as case and 25 patients were recruited as control. The risk factors of SICH in younger patients were arteriovenous malformation (45.7%), toxaemia of pregnancy (31.4%), hypertension (17.1%), cavernous angioma (2.9%), bleeding disorder (2.9%) and coagulation disorder (2.9%). In patients >45 years most of the ICH was due to HTN (52%) followed by arteriovenous malformation (20%). In conclusion arteriovenous malformation is the most common aetiological factors of young stroke patients followed by hypertension and toxaemia of pregnancy.