Miracle-dz/UniFAR-FTUs huggingface dataset:
A REFORMA PSIQUIÁTRICA - UM ESTUDO PARCIAL ACERCA DA PRODUÇÃO CIENTÍFICA DA TEMÁTICA

ABSTRACT: This work describes a theoretical reflection about the theme of the psychiatric reform in its theorics and practicals conceptions. For this objective was made a partial analysis of the scientific production about the psychiatric reform, taking like reference the abstracts published in the LILACS and in the programs and communications on the Congresso Brasileiro de Enfermagem, since 1987. For the treatment of the raised data was elected like analytical category the exclusion and like empirical category the disinstitutionalization. It was looked for the production of a vision about the psychiatric reform that approximate the health staff to the present reflections regarding new forms for to think and to act towards the craziness problematic. KEY WORDS: nursing, psychiatric.
Importance of Ankle/Brachial Pressure Index in Saudi Patients with Coronary Artery Disease

Background: The ankle/brachial pressure index (ABPI) has been shown to be a good marker of systemic atherosclerosis and a powerful predictor of cardiovascular morbidity and mortality. The objective of this study was to determine the importance of measuring ABPI in Saudi patients with coronary artery disease (CAD). METHODS: This is a hospital based cross-sectional study which was conducted on all Saudi patients who underwent coronary angiography without symptoms of peripheral arterial disease at King Fahd Hospital of the University, Al-Khobar Saudi Arabia. All patients underwent measurement of their ABPI. The study was carried out between December 2010 and November 2011. RESULTS: During the study period, two hundred and five patients were included. Fifty-nine (28.8%) patients were Group II (ABPI ≤ 0.90) and the rest was Group I (ABPI > 0.90). Significant correlation was also found between low ABPI and the extent of CAD (mean number of arteries involved in Group I was 1.78 ± 0.83 compared to 2.10 ± 0.736 in Group II p = 0.011). Nevertheless, the correlation between low ABPI, and the severity of presentation of CAD were also significant (Incidence of myocardial infarction with congestive heart failure was 0.5% in Group I compared to 12% in Group II p CONCLUSION: The ABPI is an important prognostic indicator for Saudi patients with CAD.
The Effects of Prior Knowledge, Presentation Mode, and Visual Realism on Student Achievement.

This experiment was designed to determine whether all types of visuals are equally effective in facilitating student achievement of identical educational objectives, whether students’ level of entering behavior (prior knowledge of the content) affects their ability to profit from visualization and subsequently perform on criterion tests designed to measure achievement of different educational objectives, and whether externally paced and self-paced methods of presenting visualized instruction are equally effective in facilitating student achievement of immediate and delayed retention of the content. The results indicate that students with high entering behavior achieved equivalent or significantly higher scores on the criterion measures than students with low and medium entering behavior regardless of the type of visualization or method of instruction received; the use of visualization to complement instruction is an effective instructional technique for reducing differences in achievement on the criterion.
Sentiment classification of tweets using hierarchical classification

This paper addresses the problem of sentiment classification of short messages on microblogging platforms. We apply machine learning and pattern recognition techniques to design and implement a classification system for microblog messages assigning them into one of three classes: positive, negative or neutral. As part of this work, we contributed a dataset consisting of approximately 10, 000 tweets, each labeled on a five point sentiment scale by three different people. Experiments demonstrate a detection rate between approximately 70% and an average false alarm rate of approximately 18% across all three classes. The developed classifier has been made available for online use.
Programa de habilidades interpessoais e direitos sexuais e reprodutivos para adolescentes: um relato de experiência

This paper describes the experience of applying a program of interpersonal skills and sexual and reproductive rights for adolescents. The participants were 93 adolescents, male and female, students in a public school. The intervention was universal prevention type and it was implemented at school in 15 weekly sessions organized in three thematic blocks: (I) identity and resilience; (II) social skills and emotions management; and (III) sexuality, gender and sexual and reproductive rights. The results showed the adequacy of using experienced procedures, their basis in adolescent culture the need for changing the sessions order in future versions of this program. Directions for the program redesign are discussed.
Association of Herpesvirus Saimiri Tip with Lipid Raft Is Essential for Downregulation of T-Cell Receptor and CD4 Coreceptor

ABSTRACT Lipid rafts are membrane microdomains that are proposed to function as platforms for both receptor signaling and trafficking. Our previous studies have demonstrated that Tip of herpesvirus saimiri (HVS), which is a T-lymphotropic tumor virus, is constitutively targeted to lipid rafts and interacts with cellular Lck tyrosine kinase and p80 WD repeat-containing endosomal protein. Through the interactions with Lck and p80, HVS Tip modulates diverse T-cell functions, which leads to the downregulation of T-cell receptor (TCR) and CD4 coreceptor surface expression, the inhibition of TCR signal transduction, and the activation of STAT3 transcription factor. In this study, we investigated the functional significance of Tip association with lipid rafts. We found that Tip expression remarkably increased lipid raft fractions in human T cells by enhancing the recruitment of lipid raft-resident proteins. Genetic analysis showed that the carboxyl-terminal transmembrane, but not p80 and Lck interaction, of Tip was required for the lipid raft localization and that lipid raft localization of Tip was necessary for the efficient downregulation of TCR and CD4 surface expression. Correlated with this, treatment with Filipin III, a lipid raft-disrupting agent, effectively reversed the downregulation of CD3 and CD4 surface expression induced by Tip. On the other hand, Tip mutants that were no longer present in lipid rafts were still capable of inhibiting TCR signaling and activating STAT3 transcription factor activity as efficiently as wild-type (wt) Tip. These results indicate that the association of Tip with lipid rafts is essential for the downregulation of TCR and CD4 surface expression but not for the inhibition of TCR signal transduction and the activation of STAT3 transcription factor. These results also suggest that the signaling and targeting activities of HVS Tip rely on functionally and genetically separable mechanisms, which may independently modulate T-cell function for viral persistence or pathogenesis.
First-Place Loving and Last-Place Loathing: How Rank in the Distribution of Performance Affects Effort Provision

Rank-order relative-performance evaluation, in which pay, promotion and symbolic awards depend on the rank of workers in the distribution of performance, is ubiquitous. Whenever firms use rank-order relative-performance evaluation, workers receive feedback about their rank. Using a real-effort experiment, we aim to discover whether workers respond to the specific rank that they achieve. In particular, we leverage random variation in the allocation of rank among subjects who exerted the same effort to obtain a causal estimate of the rank response function that describes how effort provision responds to the content of rank-order feedback. We find that the rank response function is U-shaped. Subjects exhibit 'first-place loving' and 'last-place loathing', that is subjects increase their effort the most after being ranked first or last. We discuss implications of our findings for the optimal design of firms' performance feedback policies, workplace organizational structures and incentives schemes.
Plasmids coding for colonization factor antigen I and heat-stable enterotoxin production isolated from enterotoxigenic Escherichia coli: comparison of their properties

We examined seven enterotoxigenic Escherichia coli strains which produced colonization factor antigen I (CFA/I). Four of these strains were from South Africa (three serotype O78:H12 and one serotype O63:H-), one was from Ethiopia (O78:H12), and two were from Bangladesh (O78:H11 and O78:H12). Plasmids coding for CFA/I were mobilized from six of these strains by using resistance or enterotoxin factors. No plasmid was mobilized from the serotype O78:H12 Bangladesh strain. The transconjugants obtained from crosses with the O78 strains also produced heat-stable enterotoxin (ST), and additional investigations showed that CFA/I and ST were coded for by a single non-autotransferring plasmid. These plasmids were fertility inhibition negative, did not restrict any of the coliphages with which they were tested, and were incompatible with each other. Four had molecular weights of approximately 60 X 10(6), and one had a molecular weight of 52 X 10(6). Like the other CFA/I plasmids, the CFA/I plasmid transferred from the O63:H- strain coded for ST, but this plasmid also coded for heat-labile enterotoxin. In most other respects the properties of this plasmid were similar to those of the CFA/I-ST plasmids previously described. The molecular weight of this plasmid was 65 X 10(6). The IncT R-factor Rtsl was marked with a transposon for tetracycline resistance and then transferred into the two Bangladesh wild-type strains. Plasmids which coded for tetracycline resistance, CFA/I, and ST were transferred from these strains. These plasmids were incompatible with Rtsl and with the CFA/I-ST plasmids described above and were recombinants between Rtsl and a CFA/I-ST plasmid. Their properties are also described.
Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1

Recognition of methylated histone tail lysine residues by tudor domains plays important roles in epigenetic control of gene expression and DNA damage response. Previous studies revealed the binding of methyllysine in a cage of aromatic residues, but the molecular mechanism by which the sequence specificity for surrounding histone tail residues is achieved remains poorly understood. In the crystal structure of a trimethylated histone H3 lysine 4 (H3K4) peptide bound to the tudor-like domains of Spindlin1 presented here, an atypical mode of methyllysine recognition by an aromatic pocket of Spindlin1 is observed. Furthermore, the histone sequence is recognized in a distinct manner involving the amino terminus and a pair of arginine residues of histone H3, and disruption of the binding impaired stimulation of pre-RNA expression by Spindlin1. Our analysis demonstrates considerable diversities of methyllysine recognition and sequence-specific binding of histone tails by tudor domains, and the revelation furthers the understanding of tudor domain proteins in deciphering epigenetic marks on histone tails.
Lack of radiation protection for endoscopists performing endoscopic retrograde cholangiopancreatography.

BACKGROUND/AIMS ERCP using fluoroscopy should be practiced with an adequate radiation protection. However, the awareness of gastrointestinal endoscopists to radiation protection was considered insufficient. In Korea, a country with a rapid increase the number of ERCP procedures, there is no data about radiation protection practices for gastrointestinal endoscopists. The purpose of this study was to investigate current clinical practices and the awareness on radiation protection in ERCP performing physicians in Korea. METHODS An anonymous questionnaire regarding radiation protection practices was mailed to 100 members of Korean Pancreatobiliary Association who was porforming ERCP. The questionnaire included ERCP volume of each endoscopist, use of protection devices such as apron, thyroid shield, lead glasses and any mobile shield for scattered radiation, and whether they monitored their own radiation exposure dosage. RESULTS All respondents wore lead aprons during ERCP. While 52.5% of endoscopists answered that they always wear thyroid guards, 26.9% rarely or never wore it. Only 14% wore lead glasses during the procedure and 69% never wore it. The preparation rates of mobile shields or lead curtains were only 14% and 24%, respectively. Only 10% of endoscopists attached an X-ray badge and 66.7% never used it. Moreover, 75% of endoscopists responded that they did not monitor their own exposure dose to radiation during ERCP. CONCLUSIONS The lack of radiation protection of ERCP endoscopists in Korea was seemed serious. Awareness of radiation hazard should be more concerned and educated in parallel with the preparation of radiation protection equipments.
Serotonin 5-HTTLPR Genotype Modulates Reactive Visual Scanning of Social and Non-social Affective Stimuli in Young Children

Previous studies have documented the 5-HTTLPR polymorphisms as genetic variants that are involved in serotonin availability and also associated with emotion regulation and facial emotion processing. In particular, neuroimaging and behavioral studies of healthy populations have produced evidence to suggest that carriers of the Short allele exhibit heightened neurophysiological and behavioral reactivity when processing aversive stimuli, particularly in brain regions involved in fear. However, an additional distinction has emerged in the field, which highlights particular types of fearful information, i.e., aversive information which involves a social component versus non-social aversive stimuli. Although processing of each of these stimulus types (social and non-social) is believed to involve a subcortical neural system which includes the amygdala, evidence also suggests that the amygdala itself may be particularly responsive to socially significant environmental information, potentially due to the critical relevance of social information for humans. Examining individual differences in neurotransmitter systems which operate within this subcortical network, and in particular the serotonin system, may be critically informative for furthering our understanding of the neurobiological mechanisms underlying responses to emotional and affective stimuli. In the present study we examine visual scanning patterns in response to both aversive and positive images of a social or non-social nature in relation to 5-HTTLPR genotypes, in 49 children aged 4–7 years. Results indicate that children with at least one Short 5-HTTLPR allele spent less time fixating the threat-related non-social stimuli, compared with participants with two copies of the Long allele. Interestingly, a separate set of analyses suggests that carriers of two copies of the short 5-HTTLPR allele also spent less time fixating both the negative and positive non-social stimuli. Together, these findings support the hypothesis that genetically mediated differences in serotonin availability mediate behavioral responses to different types of emotional stimuli in young children.
Estimation of Energy Balance Components over a Drip-Irrigated Olive Orchard Using Thermal and Multispectral Cameras Placed on a Helicopter-Based Unmanned Aerial Vehicle (UAV)

A field experiment was carried out to implement a remote sensing energy balance (RSEB) algorithm for estimating the incoming solar radiation (Rsi), net radiation (Rn), sensible heat flux (H), soil heat flux (G) and latent heat flux (LE) over a drip-irrigated olive (cv. Arbequina) orchard located in the Pencahue Valley, Maule Region, Chile (35°25′S; 71°44′W; 90 m above sea level). For this study, a helicopter-based unmanned aerial vehicle (UAV) was equipped with multispectral and infrared thermal cameras to obtain simultaneously the normalized difference vegetation index (NDVI) and surface temperature (Tsurface) at very high resolution (6 cm × 6 cm). Meteorological variables and surface energy balance components were measured at the time of the UAV overpass (near solar noon). The performance of the RSEB algorithm was evaluated using measurements of H and LE obtained from an eddy correlation system. In addition, estimated values of Rsi and Rn were compared with ground-truth measurements from a four-way net radiometer while those of G were compared with soil heat flux based on flux plates. Results indicated that RSEB algorithm estimated LE and H with errors of 7% and 5%, respectively. Values of the root mean squared error (RMSE) and mean absolute error (MAE) for LE were 50 and 43 W m−2 while those for H were 56 and 46 W m−2, respectively. Finally, the RSEB algorithm computed Rsi, Rn and G with error less than 5% and with values of RMSE and MAE less than 38 W m−2. Results demonstrated that multispectral and thermal cameras placed on an UAV could provide an excellent tool to evaluate the intra-orchard spatial variability of Rn, G, H, LE, NDVI and Tsurface over the tree canopy and soil surface between rows.
Behavioral Determinants of Health Aging Revisited: An Update on the Good News for the Baby Boomer Generation

On October 15th, 2007, Kathleen Casey-Kirschling became the first Baby Boomer to ride the "silver tsunami" by applying for her social security benefits. Riding a wave is an appropriate analogy for Baby Boomers given the expectations they have for their later years. Now, just as it was in the original 2003 Behavioral Determinants article, the answer to the question, “Can this generation of Americans expect to achieve a satisfying, high- quality life as older adults? ” is still a resounding yes. But now, there is greater clarity and more specific detail as to exactly what the Baby Boomer generation should, and can, be doing to insure that they have the quality of life as older adults that they have become accustomed to in their younger years. To that end, this article will examine the updated recommendations for physical activity and psychological elements associated with healthy aging.
The role of human resource practices in petro-chemical refinery performance

This study examined the impact of human resource (HR) practices (selection, training, compensation and appraisal) and participation on the financial performance of US petro-chemical refineries. Survey results from HR and operations respondents indicated that appraisal and training were significantly related to workforce skills and that training and compensation were marginally related to workforce motivation. In addition, only training was significantly related to refinery performance, although the relationship was negative. However, selection, compensation and appraisal interacted with participation in determining refinery financial performance such that each of these practices was strongly positively related to financial performance only under highly participative systems. Implications are discussed.
Mixed feelings?: the relationship between perceived usability and user experience in the wild

Although both user experience and perceived usability have been extensively studied, the relationship between the two is less well understood. Prior empirical research suggests that perceived usability influences especially negative user experiences, but the effect depend on goals, contexts, and expectations. The paper contributes on this theme with description of a field study covering self-reporting of 12 subjects using a new smartphone. The findings confirm some earlier views on the relationship but also permit a richer understanding. Unlike prior work, the results show that perceived usability can play an important role in ambivalent experiential episodes. These episodes emerge from a clash between desired uses and either poor perceived usability or lack of appropriateness in the broader social context. We discuss our findings in relation to prior studies.
Upregulation of miRNA-4776 in Influenza Virus Infected Bronchial Epithelial Cells Is Associated with Downregulation of NFKBIB and Increased Viral Survival

Influenza A virus (IAV) infection remains a significant cause of morbidity and mortality worldwide. One key transcription factor that is activated upon IAV infection is nuclear factor Kappa B (NF-κB). NF-κB regulation involves the inhibitor proteins NF-κB inhibitor beta (NFKBIB), (also known as IκB β), which form complexes with NF-κB to sequester it in the cytoplasm. In this study, microarray data showed differential expression of several microRNAs (miRNAs) on exposure to IAV. Target scan analysis revealed that miR-4776, miR-4514 and miR-4742 potentially target NFKBIB messenger RNA (mRNA). Time-course analysis of primary bronchial epithelial cells (HBEpCs) showed that miR-4776 expression is increased within 1 h of infection, followed by its downregulation 4 h post-exposure to IAV. NFKBIB upregulation of miR-4776 correlated with a decrease in NFKBIB expression within 1 h of infection and a subsequent increase in NFKBIB expression 4 h post-infection. In addition, miRNA ago-immunoprecipitation studies and the three prime untranslated region (3’ UTR) luciferase assay confirmed that miR-4776 targets NFKBIB mRNA. Furthermore, uninfected HBEpCs transfected with miR-4776 mimic showed decreased expression of NFKBIB mRNA. Overexpression of NFKBIB protein in IAV infected cells led to lower levels of IAV. Taken together, our data suggest that miRNA-4776 modulates IAV production in infected cells through NFKBIB expression, possibly through the modulation of NF-κB.
The role of incentive based Demand Response programs in smart grid

Smart Grid promises the highest efficiency in the history of electrical energy and one of its key components is Demand Response (DR). Incentive based programs however would have a different path in smart grid and their usage would be different in this new environment. In this paper, incentive based DR programs are briefly introduced, smart grid is presented and the influence of smart grid on incentive based DR programs is described considering the effect of Real Time Pricing (RTP). Finally, an existing model has been upgraded in order to analyze incentive based programs in smart grid. Eventually the influence of a typical demand bidding program is simulated on the load curve of a day in smart grid in the presence of RTP program.
Negotiating the Transition from Primary to Secondary School

The transition from primary to secondary school is regarded as one of the most difficult in pupils' educational careers. This article describes the results of a survey undertaken in the UK, in which the views of primary pupils, secondary pupils, parents and teachers were ascertained in regard to the transition process. Specifically, we sought to determine the concerns and expectations of respondents and also to establish the extent to which the views of the four groups were in accordance with one another. A total of 472 respondents completed the survey. Results showed that bullying was a major concern for all groups, followed by fears of getting lost, increased workload and peer relationships, among others. The concerns of British pupils were broadly similar to those reported in the literature for pupils in other countries. The views of primary pupils and their parents were highly similar, and if the experience of transition is to be improved, it may be necessary to focus efforts on both of these groups. Teachers rarely identified children's individual abilities as making a difference to the transition process, focusing instead on institutional initiatives, an emphasis that carries the risk of creating a degree of helplessness for individual pupils.