Miracle-dz/UniFAR-FTUs huggingface dataset:
Global Prevalence of Autism and Other Pervasive Developmental Disorders

We provide a systematic review of epidemiological surveys of autistic disorder and pervasive developmental disorders (PDDs) worldwide. A secondary aim was to consider the possible impact of geographic, cultural/ethnic, and socioeconomic factors on prevalence estimates and on clinical presentation of PDD. Based on the evidence reviewed, the median of prevalence estimates of autism spectrum disorders was 62/10 000. While existing estimates are variable, the evidence reviewed does not support differences in PDD prevalence by geographic region nor of a strong impact of ethnic/cultural or socioeconomic factors. However, power to detect such effects is seriously limited in existing data sets, particularly in low‐income countries. While it is clear that prevalence estimates have increased over time and these vary in different neighboring and distant regions, these findings most likely represent broadening of the diagnostic concets, diagnostic switching from other developmental disabilities to PDD, service availability, and awareness of autistic spectrum disorders in both the lay and professional public. The lack of evidence from the majority of the world's population suggests a critical need for further research and capacity building in low‐ and middle‐income countries. Autism Res 2012, 5: 160–179. © 2012 International Society for Autism Research, Wiley Periodicals, Inc.
GENETIC FACTORS IN RESISTANCE TO MALARIA

There is good evidencesome of which is reviewed in this monograph-that when a population of animals is repeatedly exposed to an infectious disease producing significant mortality, the progeny of surviving animals show through several generations increasing resistance to the disease. It would be generally agreed that this is a process of selection of genetically resistant animals. However, as a rule the genetic factors affecting resistance to disease are complex, depending upon many genes affecting antibody synthesis and other reactions. In the case of malaria in man, however, considerable genetic resistance is known to be conferred by two major genes, the sickle-cell gene and the glucosed-phosphate dehydrogenase-deficiency gene; there is also strong circumstantial evidence that the same is true of other abnormal hemoglobin genes. The delicate interplay of these and other more complex genetic and environmental factors with acquired immunity to malaria will be discussed in this paper.
Differential perceptions of employers' inducements: implications for psychological contracts

This paper reports findings from an exploratory study that addresses the question of whether or not measures of perceptual ‘gaps’ in organizational inducements contribute unique explanatory power above and beyond such familiar measures as employee job attitudes. Perceptions of inducements were obtained from both employees and representatives of their organizations. An average of 12 executives responded for each of four organizations to provide the organizations' view of the inducements offered to their employees, and a total of 339 employees across the four organizations reported their views of the inducements in the respective organizations. It was found that the larger the gap between what the employees viewed as the inducements offered them and what their employers reported offering them the lower was the employees' satisfaction with their organization, even after controlling for employee job satisfaction and employee performance. This finding, as well as the finding that in a substantial number of cases the employees report greater amounts of inducements than do their organizations' representatives, was explored for its implications for research on psychological contracts. Copyright © 1998 John Wiley & Sons, Ltd.
Sharing and Confronting Propositions in Collaborative Inquiry Learning

This study investigates how collaborative knowledge construction within an inquiry learning environment can be assisted with scaffolds that aim to support students' hypothesis generation process. Sixty-six students on a university preparatory track worked collaboratively on a kinematics task. The instructional goal was to develop students' understanding of one-dimensional kinematics. All students completed a proposition test in which they indicated their individual opinions about the truth-value of specific propositions. Subsequently, students were coupled into dyads and assigned to one of three conditions: (a) a shared proposition scratchpad (expression builder), (b) a shared proposition table, and (c) a control condition. Students in the scratchpad condition were given an expression builder consisting of dropdown menus with pre-defined variables and relations. Students in the shared proposition table condition could combine individual opinions about the truth-value of a proposition into one shared proposition table that highlighted differences in opinion. Students in the control condition received no extra support related to propositions. Learning outcomes were assessed using a variety of pre- and posttests. The findings indicate that students supported with the shared proposition table showed significant gains for qualitative knowledge about relations. The number of unique propositions students discussed during the learning session was a significant predictor of learning gains. A more detailed analysis of students' interaction protocols suggests that students differed in their task perceptions, their interaction patterns, and their use of prior knowledge.
Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer's Disease

Mitochondrial dysfunctions are supposed to be responsible for many neurodegenerative diseases dominating in Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). A growing body of evidence suggests that defects in mitochondrial metabolism and particularly of electron transport chain may play a role in pathogenesis of AD. Structurally and functionally damaged mitochondria do not produce sufficient ATP and are more prominent in producing proapoptotic factors and reactive oxygen species (ROS), and this can be an early stage of several mitochondrial disorders, including neurodegenerative diseases. Mitochondrial dysfunctions may be caused by both mutations in mitochondrial or nuclear DNA that code mitochondrial components and by environmental causes. In the following review, common aspects of mitochondrial impairment concerned about neurodegenerative diseases are summarized including ROS production, impaired mitochondrial dynamics, and apoptosis. Also, damaged function of electron transport chain complexes and interactions between pathological proteins and mitochondria are described for AD particularly and marginally for PD and HD.
Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis

In healthy individuals, one exercise bout induces a substantial increase in the number of circulating leukocytes, while their function is transiently suppressed. The effect of one exercise bout in multiple sclerosis (MS) is less studied. Since recent evidence suggests a role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of one combined endurance/resistance exercise bout on the number and function of DC in MS patients and healthy controls. Our results show a rapid increase in the number of DC in response to physical exercise in both MS patients and controls. Further investigation revealed that in particular DC expressing the migratory molecules CCR5 and CD62L were increased upon acute physical activity. This may be mediated by Flt3L- and MMP-9-dependent mobilization of DC, as demonstrated by increased circulating levels of Flt3L and MMP-9 following one exercise bout. Circulating DC display reduced TLR responsiveness after acute exercise, as evidenced by a less pronounced upregulation of activation markers, HLA-DR and CD86, on plasmacytoid DC and conventional DC, respectively. Our results indicate mobilization of DC, which may be less prone to drive inflammatory processes, following exercise. This may present a negative feedback mechanism for exercise-induced tissue damage and inflammation.
Transcriptome Pyrosequencing of the Parasitoid Wasp Cotesia vestalis: Genes Involved in the Antennal Odorant-Sensory System

Cotesia vestalis is an endoparasitic wasp that attacks larvae of the diamondback moth (Plutella xylostella), a herbivore of cruciferous plants. Females of C. vestalis use herbivore-induced plant odorants released from plants infested by P. xylostella as a host-searching cue. Transcriptome pyrosequencing was used to identify genes in the antennae of C. vestalis adult females coding for odorant receptors (ORs) and odorant binding proteins (OBPs) involved in insect olfactory perception. Quantitative gene expression analyses showed that a few OR and OBP genes were expressed exclusively in the antenna of C. vestalis adult females whereas most other classes of genes were expressed in the antennae of both males and females, indicating their diversity in importance for the olfactory sensory system. Together, transcriptome profiling of C. vestalis genes involved in the antennal odorant-sensory system helps in detecting genes involved in host- and food-search behaviors through infochemically-mediated interactions.
Did Graduate Journalism Education Make a Difference? A Study of British Journalism Students' Views on News Media Roles

Journalism educators in democracies aim to produce journalists motivated to scrutinize the powerful. This study of British journalism students in graduate programs considers whether their views on the news media's societal roles changed during that education. Students grew more adversarial as regards public officials, but became less likely—in an era when media audiences are fragmenting—to see journalism's role as addressing the widest possible audience. Students' views differed by gender and by whether they were in print or broadcast specialties. Their views are compared with those of experienced British journalists. Findings are contextualized with those of international studies.
Stem Cells as Potential Targeted Therapy for Inflammatory Bowel Disease

Abstract:The incidence and prevalence of inflammatory bowel disease is increasing in Western countries. Current therapies, ranging from anti-inflammatory drugs, immunosuppressive regimens to new biological therapies, remain inadequate. Advances in our understanding of the pathophysiological mechanisms underlying the pathogenetic disease process and the recent findings on the regenerative and immunoregulatory potential of stem cells open new opportunities in the therapy of inflammatory bowel disease. Therapeutic modalities, including hematopoietic stem cells, adult mesenchymal stem/stromal cells, and the recently identified amniotic origin stem cells, attracted much attention in the recent years. The current review highlights the recent pivotal findings for stem cell–based approaches to inflammatory bowel disease therapy.
A Simple Bioconjugate Attachment Protocol for Use in Single Molecule Force Spectroscopy Experiments Based on Mixed Self-Assembled Monolayers

Single molecule force spectroscopy is a technique that can be used to probe the interaction force between individual biomolecular species. We focus our attention on the tip and sample coupling chemistry, which is crucial to these experiments. We utilised a novel approach of mixed self-assembled monolayers of alkanethiols in conjunction with a heterobifunctional crosslinker. The effectiveness of the protocol is demonstrated by probing the biotin-avidin interaction. We measured unbinding forces comparable to previously reported values measured at similar loading rates. Specificity tests also demonstrated a significant decrease in recognition after blocking with free avidin.
Demand Characteristics Associated with Semantic Differential Ratings of Nouns and Verbs

RECENT attention has been focussed on motives which are specific to the role of the Subject (S) in a psychological experiment, and the ways in which behavior related to these motives confound the observations made in psychological research. Orne (1962) has proposed that Ss are motivated to perform in the manner that they perceive the Experimenter’s (E) hypothesis requires that they perform, and that they are attuned to cues within the experimental situation which will suggest to them the desired mode of response. These cues, as they are perceived by the S, are termed &dquo;demand
The Operation Sequence Model—Combining N-Gram-Based and Phrase-Based Statistical Machine Translation

In this article, we present a novel machine translation model, the Operation Sequence Model (OSM), which combines the benefits of phrase-based and N-gram-based statistical machine translation (SMT) and remedies their drawbacks. The model represents the translation process as a linear sequence of operations. The sequence includes not only translation operations but also reordering operations. As in N-gram-based SMT, the model is: (i) based on minimal translation units, (ii) takes both source and target information into account, (iii) does not make a phrasal independence assumption, and (iv) avoids the spurious phrasal segmentation problem. As in phrase-based SMT, the model (i) has the ability to memorize lexical reordering triggers, (ii) builds the search graph dynamically, and (iii) decodes with large translation units during search. The unique properties of the model are (i) its strong coupling of reordering and translation where translation and reordering decisions are conditioned on n previous translation and reordering decisions, and (ii) the ability to model local and long-range reorderings consistently. Using BLEU as a metric of translation accuracy, we found that our system performs significantly better than state-of-the-art phrase-based systems (Moses and Phrasal) and N-gram-based systems (Ncode) on standard translation tasks. We compare the reordering component of the OSM to the Moses lexical reordering model by integrating it into Moses. Our results show that OSM outperforms lexicalized reordering on all translation tasks. The translation quality is shown to be improved further by learning generalized representations with a POS-based OSM.
Lemniscal and Extralemniscal Compartments in the VPM of the Rat

The ventral posteromedial thalamic nucleus (VPM) of the rat contains at least two major vibrissa-representing compartments: the dorsomedial (VPMdm), which belongs to the lemniscal afferent pathway, and the ventrolateral (VPMvl), which belongs to the extralemniscal afferent pathway. Although input–output projections and functional characteristics that distinguish these two compartments were recently clarified, a comprehensive structural analysis of these compartments and the border between them was lacking. This paper addresses structural and functional relationships between the VPMdm and VPMvl. We found that the size of the VPM is almost constant across individual rats. Next, we computed a canonical map of the VPM in the oblique plane, where structural borders are best visualized. Using the canonical map, and sequential slices cut in oblique and coronal planes, we determined the border between the VPMdm and VPMvl in the standard coronal plane, and verified it with in vivo extracellular recordings. The position of the border between these two vibrissal sub-nuclei changes along the rostrocaudal extent within the VPM due to the relative sizes of these sub-nuclei at any point. The border between the VPMdm and VPMvl, which was revealed by this technique, can now be included in atlases of the rat brain and should facilitate experimental correlation of tactile functions with thalamic regions.
Effects of arousal‐ and feeding‐related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat

Many neuropeptides regulate feeding and arousal; the ventral tegmental area (VTA) is likely to be one site where they act. We used whole‐cell patch‐clamp and single‐unit extracellular recordings to examine the effects of such neuropeptides on the activity of VTA neurons. Substance P (SP; 300 nm) increased the firing rate of the majority of VTA dopaminergic and γ‐aminobutyric acid (GABA)ergic neurons, and induced oscillations in two dopaminergic cells. Corticotropin‐releasing factor (CRF; 200 nm) excited the majority of VTA cells directly, whereas neuropeptide Y (NPY; 300 nm) directly inhibited a subset of dopaminergic and GABAergic cells. Consecutive application of several neuropeptides revealed that all the neurons were excited by at least one of the excitatory neuropeptides SP, CRF or/and orexins. α‐Melanocyte‐stimulating hormone had no effect on dopaminergic cells (at concentrations of 500 nm and 1 µm) and affected only a small proportion of GABAergic neurons. Ghrelin (500 nm), agouti‐related peptide (1 µm); cocaine and amphetamine‐related transcript (500 nm) and leptin (500 nm and 1 µm) did not modulate the firing rate and membrane potential of VTA neurons. Single‐cell reverse transcription polymerase chain reaction analysis showed that all NPY receptors were present in VTA neurons, and all but one cell expressed NPY and/or at least one NPY receptor. CRF was expressed in 70% of dopaminergic VTA cells; the expression of CRF receptor 2 was more abundant than that of receptor 1. These findings suggest a link between the ability of neuropeptides to promote arousal and their action on VTA neurons.
The Costs of Suppressing Negative Emotions and Amplifying Positive Emotions During Parental Caregiving

How do parents feel when they regulate their emotional expressions in ways that are incongruent with their genuine feelings? In an experimental study, parents reported experiencing lower authenticity, emotional well-being, relationship quality, and responsiveness to their children’s needs when they recalled caregiving experiences in which they suppressed negative emotions and amplified positive emotions, relative to a control condition. In a 10-day daily experience study, parents tended to use both regulation strategies simultaneously. In addition, assessing their unique effects indicated that positive emotion amplification, but not negative emotion suppression, had an indirect effect on parental outcomes via authenticity, with negative emotion suppression no longer being costly. This indirect effect was dampened when accounting for care difficulty. In both studies, effects were independent of a child’s mood. The current results suggest that parents’ attempts to suppress negative and amplify positive emotions during child care can detract from their well-being and high-quality parent–child bonds.
Leadership style, salesperson's work effort and job performance: the influence of power distance

As multinational organizations increase operations in emerging economies, firms need to understand how cultural values prevailing in a host country can influence leadership practices developed and practiced in Western economies. This study explores the relationships among leadership styles and salespeople's attitudes and behaviours with data from salespeople in India with power distance measured at the individual level. Results suggest that for employees' instrumental leadership is more effective in promoting employee effort and increasing job performance. In addition, the relationship between satisfaction with supervisor and turnover intentions is weaker or insignificant, while the relationship between satisfaction with supervisor and effort is stronger for employees in higher power distance organizations. The study highlights cultural sensitivities that need to be considered in formulating an effective leadership style in emerging market contexts.
Age-Differentiated Communication in Organizations: Perspectives from Thailand and the United States

To test hypotheses about intra- and intergenerational communication perceptions, university students with work experience (n = 277) from two nations (Thailand and the United States) self-assessed their communication beliefs on the Global Perceptions of Intergenerational Communication scale. Using communication accommodation theory as a theoretical backdrop, results revealed that, irrespective of culture, young workers perceived older workers as more nonaccommodative (e.g., more negative, more self-centered) than young workers, though young workers still felt more obligation to be polite and “respectfully avoidant” in their communication to older workers. Cross-cultural differences emerged only to the extent that young Americans reported receiving greater accommodation from workers, in general, than did Thais.
Determinants of Revisit Intention to a Hot Springs Destination: Evidence from Taiwan

This study develops a structural model for understanding the effects of destination personality, cuisine experience and psychological well-being on tourists' revisit intentions to a hot springs destination. An on-site questionnaire was administered to 315 Taiwanese tourists at Bei-Tou hot springs. The results indicated that destination personality, cuisine experience and psychological well-being were important determinants of revisit intention. In addition, ‘health’ was the strongest dimension for cuisine experience, and ‘healthy’ was the dominant dimension for destination personality. The findings suggest that future efforts to understand the revisitation decision-making process should consider tourists' aspirations for the pursuit of health. Implications for theory and practice are provided.
The audiospinal reaction in parkinsonian patients reflects functional changes in reticular nuclei

Audiospinal facilitation using the soleus H‐reflex as a test was compared in 16 control subjects and 23 parkinsonian patients. In the patients, facilitation was significantly reduced during the 75 to 150 msec after the conditioning stimulation. This reduction was seen bilaterally even in patients with a hemisyndrome. It was corrected by L‐dopa but not by anticholinergic agents. Facilitation at the 75‐msec delay showed an inverse linear correlation with the bradykinesia intensity (r = ‐0.7, p < 0.01). The results argue in favor of a reduced excitability of the nucleus reticularis pontis caudalis from which a reticulospinal tract emanates as effector of the audiospinal facilitation. This would represent another example of dysfunction of reticular nuclei in Parkinson's disease.
Docking, CoMFA and CoMSIA studies of a series of sulfonamides derivatives as carbonic anhydrase I inhibitors

3D-QSAR methods, CoMFA region focusing (CoMFA-RF) and CoMSIA along with docking studies carried out for investigating 32 carbonic anhydrase I inhibitors. These inhibitors have been studied for the development of antiglaucoma, antitumor, antiobesity or anticonvulsant drugs. Docking analysis by GOLD provide conformations which have been realigned in CoMFA and CoMSIA models. Training set for the CoMFA–RF and CoMSIA models using 24 docked conformations gives q2Loo values of 0.615 and 0.637 and r2nv values of 0.701 and 0.713, respectively. The results of CoMFA-RF and CoMSIA with and without docked conformations were compared. The ability of prediction and robustness of the models were evaluated by test set, cross validation (leave-one-out and leave-ten-out), bootstrapping, and progressive scrambling approaches. The all-orientation search (AOS) was used to achieve the best orientation to minimize the effect of initial orientation of the structures. The docking results confirmed CoMFA and CoMSIA contour maps.