Miracle-dz/UniFAR-FTUs huggingface dataset:
An Objective Comparison of Two Recent Neutral Theophylline Compounds with Aminophylline

concurrent sarcoidosis, miliary tuberculosis, pneumonia, prostatectomy plus infection, prostatectomy alone, and a cerebrovascular incident, while in the remaining three patients no accompaniment was assigned. Nevertheless, two of the last three cases had, like the penultimate case cited, well-defined arteriosclerosis, as had the patient with pneumonia and the two who had just undergone prostatectomy. By contrast, in the nine females the simultaneous features were the antepartum phase in four, post-partum haemorrhage in two, the puerperium without mention of haemorrhage in one, and one had no specified concomitant. 3. High Fatality Rate. -Death occurred in 14 out of 18 cases, and was characterized by its rapid occurrence (three months or less in 10 cases) and by a terminal hypoglycaemia in at least nine patients, of whom two had received a timely and liberal intravenous infusion of dextrose. The four later deaths occurred two to four years later and all had signs of hypopituitarism.
Acute coronary syndromes and diabetes mellitus

Patients with diabetes mellitus who present with acute ST-segment elevation myocardial infarction or non-ST-segment elevation acute coronary syndromes have a higher risk of adverse outcomes than patients without diabetes, and appear to derive greater benefit from evidence-based therapies. However, patients with diabetes mellitus are less commonly treated with proven therapies, so renewed efforts are needed to improve the quality of care and outcomes for patients with diabetes mellitus who present with acute coronary syndromes.
Changes in Atrial Fibrillation Cycle Length and Inducibility During Catheter Ablation and Their Relation to Outcome

Background—The modification of atrial fibrillation cycle length (AFCL) during catheter ablation in humans has not been evaluated. Methods and Results—Seventy patients undergoing ablation of prolonged episodes of AF were randomized to pulmonary vein (PV) isolation or additional ablation of the mitral isthmus. Mean AFCL was determined at a distance from the ablated area (coronary sinus) at the following intervals: before ablation, after 2- and 4-PV isolations, and after linear ablation. Inducibility of sustained AF (≥10 minutes) was determined before and after ablation. Spontaneous sustained AF (715±845 minutes) was present in 30 patients and induced in 26 (AFCL, 186±19 ms). PV isolation terminated AF in 75%, with the number of PVs requiring isolation before termination increasing with AF duration (P =0.018). PV isolation resulted in progressive or abrupt AFCL prolongation to various extents, depending on the PV: to 214±24 ms (P <0.0001) when AF terminated and to 194±19 ms (P <0.002) when AF persisted. The increase in AFCL (30±17 versus 14±11 ms; P =0.005) and the decrease in fragmentation (30.0±26.8% to 10.3±14.5%; P <0.0001) were significantly greater in patients with AF termination. Linear ablation prolonged AFCL, with a greater prolongation in patients with AF termination (44±13 versus 22±23 ms; P =0.08). Sustained AF was noninducible in 57% after PV isolation and in 77% after linear ablation. At 7±3 months, 74% with PV isolation and 83% with linear ablation were arrhythmia free without antiarrhythmics, which was significantly associated with noninducibility (P =0.03) with a recurrence rate of 38% and 13% in patients with and without inducibility, respectively. Conclusions—AF ablation results in a decline in AF frequency, with a magnitude correlating with termination of AF and prevention of inducibility that is predictive of subsequent clinical outcome.
Clonal reproduction in fungi

Research over the past two decades shows that both recombination and clonality are likely to contribute to the reproduction of all fungi. This view of fungi is different from the historical and still commonly held view that a large fraction of fungi are exclusively clonal and that some fungi have been exclusively clonal for hundreds of millions of years. Here, we first will consider how these two historical views have changed. Then we will examine the impact on fungal research of the concept of restrained recombination [Tibayrenc M, Ayala FJ (2012) Proc Natl Acad Sci USA 109 (48):E3305–E3313]. Using animal and human pathogenic fungi, we examine extrinsic restraints on recombination associated with bottlenecks in genetic variation caused by geographic dispersal and extrinsic restraints caused by shifts in reproductive mode associated with either disease transmission or hybridization. Using species of the model yeast Saccharomyces and the model filamentous fungus Neurospora, we examine intrinsic restraints on recombination associated with mating systems that range from strictly clonal at one extreme to fully outbreeding at the other and those that lie between, including selfing and inbreeding. We also consider the effect of nomenclature on perception of reproductive mode and a means of comparing the relative impact of clonality and recombination on fungal populations. Last, we consider a recent hypothesis suggesting that fungi thought to have the most severe intrinsic constraints on recombination actually may have the fewest.
Predicting protein folding cores based on complex network and phylogenetic analyses

A crucial event of protein folding is the formation of a folding core, which is the subset of the protein's structure that is the first to form during folding and the last to break during denaturation. Both experimental and simulation techniques to capture folding core membership have found it challenging. In this paper, the six different computational prediction methods were proposed to predict folding core residues from a protein structure. The protein structure is modeled as an undirected network with the amino acids the vertexes and the contacts between them the edges. We find that the core residues have mainly high degree and low clustering coefficient compared with the surface residues. The closeness values of core residues are similar with the surface residues. The degree distribution of core and surface residues all are Poisson distribution. This suggests that the same small-world organization prevails throughout the protein, despite the heterogeneous density distribution. The six different centrality measurements have been proposed to predict folding core residues from a set of 14 well-characterized proteins. We show that the six measurements (degree, clustering coefficient, closeness centrality, betweenness, conservation score and solvent accessible surface area) all accurately detect the folding core residues. The best methods are based on the solvent accessible surface area and the local centrality measurement closeness. This indicates that the folding core residues have high hydrophobicity and tightness packed.
Conserved charges for black holes in Einstein-Gauss-Bonnet gravity coupled to nonlinear electrodynamics in AdS space

Motivated by possible applications within the framework of anti-de Sitter gravity/conformal field theory correspondence, charged black holes with AdS asymptotics, which are solutions to Einstein-Gauss-Bonnet gravity in $D$ dimensions, and whose electric field is described by nonlinear electrodynamics are studied. For a topological static black hole ansatz, the field equations are exactly solved in terms of the electromagnetic stress tensor for an arbitrary nonlinear electrodynamic Lagrangian in any dimension $D$ and for arbitrary positive values of Gauss-Bonnet coupling. In particular, this procedure reproduces the black hole metric in Born-Infeld and conformally invariant electrodynamics previously found in the literature. Altogether, it extends to $Dg4$ the four-dimensional solution obtained by Soleng in logarithmic electrodynamics, which comes from vacuum polarization effects. Falloff conditions for the electromagnetic field that ensure the finiteness of the electric charge are also discussed. The black hole mass and vacuum energy as conserved quantities associated to an asymptotic timelike Killing vector are computed using a background-independent regularization of the gravitational action based on the addition of counterterms which are a given polynomial in the intrinsic and extrinsic curvatures.
Oral omega-3 fatty acid for reduction of kidney dysfunction induced by reperfusion injury in rats.

INTRODUCTION The aim of this study was to examine the effects of oral administration of omega-3 fatty acid on kidney functional disturbances, histological damages, and oxidative stress due to reperfusion injury. MATERIALS AND METHODS Male Sprague Dawley rats received a standard diet for 2 weeks. Through gavage, the rats in acute kidney failure and omega-3 groups received 4 mL normal saline or omega-3 fatty acid (0.4 g/kg) daily. After 2 weeks, the rats underwent surgery and renal ischemia on both sides. During the last 6 hours, the rats were transferred to the metabolic cage for urine sampling. At the end of the period, blood samples were obtained from the aorta and the kidneys were removed for hematoxylin-eosin staining, histological analysis, and oxidative stress measurement. The sham group also received normal saline, but the operation was done without renal ischemia, whereas the control group did not received any substances or operation. RESULTS The decrease in glomerular filtration rate induced by reperfusion was relatively improved by omega-3 administration, which resulted in the decrease in plasma urea and creatinine concentrations. In addition, the relative excretion of sodium and potassium, and urine flow rate decreased in the omega-3 group as compared with the acute kidney failure group. The degrees of histologic damages and oxidative stress that had increased following reperfusion injury were also significantly lowered by omega-3 administration. CONCLUSIONS Preventive oral administration of omega-3 supplement may decrease histological damages, oxidative stress, and kidney dysfunction following reperfusion injury.
Raman and FTIR microscopic imaging of colon tissue: a comparative study

Colon tissue constitutes a valid model for the comparative analysis of soft tissue by Raman and Fourier transform infrared (FTIR) imaging because it contains four major tissue types such as muscle tissue, connective tissue, epithelium and nerve cells. Raman microscopic images were recorded in the mapping mode using 785 nm laser excitation and a step size of 10 μm from three regions within a thin section that encompassed mucus, mucosa, submucosa, and longitudinal and circular muscle layers. FTIR microscopic images that were composed of 4, 8 and 9 individual images of 4096 spectra each were recorded from the same regions using a FTIR spectrometer coupled to a microscope with a focal plane array detector. Furthermore, Raman microscopic images were recorded at a step size of 2.5 μm from three ganglia that belong to the myenteric plexus. The results are discussed with respect to lateral resolution, spectral resolution, acquisition time and sensitivity of both modalities. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Can you hear me now? The experience of a deaf family member surrounding the death of loved ones

Introduction: Individuals who are Deaf face challenges both similar and unique from those faced by hearing individuals when a family member is dying. This study was guided by the question, ‘‘What are the challenges faced by a Deaf family member when a loved one is dying? ’’ Methods: This qualitative study is guided by critical theory and an interpretive perspective. Robert, a college-educated older adult who has been Deaf from birth was interviewed in American Sign Language using a death history format. Results: There are challenges for Deaf family members that affect communication with both the dying person and health care professionals. Patient-family communication issues included physical challenges and financial challenges. Lack of cultural competence concerning the Deaf community created challenges communicating with professionals. Decision-making was also a challenge. Conclusions: These findings provide a framework for future research concerning the needs of Deaf individuals facing the end of life and provide guidance for clinicians.
Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon

The pineal hormone melatonin exerts its influence in the periphery through activation of two specific trans-membrane receptors: MT1 and MT2. Both isoforms are expressed in the islet of Langerhans and are involved in the modulation of insulin secretion from β-cells and in glucagon secretion from α-cells. De-synchrony of receptor signaling may lead to the development of type 2 diabetes. This notion has recently been supported by genome-wide association studies identifying particularly the MT2 as a risk factor for this rapidly spreading metabolic disturbance. Since melatonin is secreted in a clearly diurnal fashion, it is safe to assume that it also has a diurnal impact on the blood-glucose-regulating function of the islet. This factor has hitherto been underestimated; the disruption of diurnal signaling within the islet may be one of the most important mechanisms leading to metabolic disturbances. The study of melatonin–insulin interactions in diabetic rat models has revealed an inverse relationship: an increase in melatonin levels leads to a down-regulation of insulin secretion and vice versa. Elucidation of the possible inverse interrelationship in man may open new avenues in the therapy of diabetes.
Subexponential Parameterized Algorithms for Planar and Apex-Minor-Free Graphs via Low Treewidth Pattern Covering

We prove the following theorem. Given a planar graph G and an integer k, it is possible in polynomial time to randomly sample a subset A of vertices of G with the following properties: 1) A induces a subgraph of G of treewidth O(√(k log k)), and 2) for every connected subgraph H of G on at most k vertices, the probability that A covers the whole vertex set of H is at least (2O(√k log2 k) · nO(1))-1, where n is the number of vertices of G. Together with standard dynamic programming techniques for graphs of bounded treewidth, this result gives a versatile technique for obtaining (randomized) subexponential parameterized algorithms for problems on planar graphs, usually with running time bound 2O(√(k log2 k))nO(1). The technique can be applied to problems expressible as searching for a small, connected pattern with a prescribed property in a large host graph, examples of such problems include DIRECTED k-Path, WEIGHTED k-Path, VERTEX COVER LOCAL SEARCH, and SUBGRAPH ISOMORPHISM, among others. Up to this point, it was open whether these problems can be solved in subexponential parameterized time on planar graphs, because they are not amenable to the classic technique of bidimensionality. Furthermore, all our results hold in fact on any class of graphs that exclude a fixed apex graph as a minor, in particular on graphs embeddable in any fixed surface.
Resting heart rate as a low tech predictor of coronary events in women: prospective cohort study

Objective To evaluate resting heart rate as an independent predictor of cardiovascular risk in women. Design Prospective cohort study. Setting The Women’s Health Initiative was undertaken at 40 research clinics in the United States. Participants 129 135 postmenopausal women. Main outcome measure Clinical cardiovascular events. Results During a mean of 7.8 (SD 1.6) years of follow up, 2281 women were identified with myocardial infarction or coronary death and 1877 with stroke. We evaluated associations between resting heart rate and cardiovascular events in Cox regression models adjusted for multiple covariates. Higher resting heart rate was independently associated with coronary events (hazard ratio 1.26, 95% confidence interval 1.11 to 1.42 for highest [>76 beats per minute] v lowest quintile [≤62 beats per minute]; P=0.001), but not with stroke. The relation between heart rate and coronary events did not differ between white women and women from other ethnic groups (P for interaction=0.45) or between women with and without diabetes (P for interaction=0.31), but it was stronger in women aged 50-64 at baseline than in those aged 65-79 (P for interaction=0.009). Conclusion Resting heart rate, a low tech and inexpensive measure of autonomic tone, independently predicts myocardial infarction or coronary death, but not stroke, in women. Trial registration ClinicalTrials.gov NCT00000611.
Intuitive and efficient camera control with the toric space

A large range of computer graphics applications such as data visualization or virtual movie production require users to position and move viewpoints in 3D scenes to effectively convey visual information or tell stories. The desired viewpoints and camera paths are required to satisfy a number of visual properties (e.g. size, vantage angle, visibility, and on-screen position of targets). Yet, existing camera manipulation tools only provide limited interaction methods and automated techniques remain computationally expensive. In this work, we introduce the Toric space, a novel and compact representation for intuitive and efficient virtual camera control. We first show how visual properties are expressed in this Toric space and propose an efficient interval-based search technique for automated viewpoint computation. We then derive a novel screen-space manipulation technique that provides intuitive and real-time control of visual properties. Finally, we propose an effective viewpoint interpolation technique which ensures the continuity of visual properties along the generated paths. The proposed approach (i) performs better than existing automated viewpoint computation techniques in terms of speed and precision, (ii) provides a screen-space manipulation tool that is more efficient than classical manipulators and easier to use for beginners, and (iii) enables the creation of complex camera motions such as long takes in a very short time and in a controllable way. As a result, the approach should quickly find its place in a number of applications that require interactive or automated camera control such as 3D modelers, navigation tools or 3D games.
Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC

Transcription factor IIIC (TFIIIC) is required for the assembly of a preinitiation complex on 5S RNA, tRNA, and adenovirus VA RNA genes and contains two separable components, TFIIIC1 and TFIIIC2. TFIIIC2 binds to the 3' end of the internal control region of the VAI RNA gene and contains five polypeptides ranging in size from 63 to 220 kDa; the largest of these directly contacts DNA. Here we describe the cloning of cDNAs encoding all (rat) or part (human) of the 220-kDa subunit (TFIIIC alpha). Surprisingly, TFIIIC alpha has no homology to any of the yeast TFIIIC subunits already cloned, suggesting a significant degree of evolutionary divergence for RNA polymerase III factors. Antibodies raised against the N terminus of recombinant human TFIIIC alpha specifically inhibit binding of natural TFIIIC to DNA. Furthermore, immunodepletion assays indicate that TFIIIC alpha is absolutely required for RNA polymerase III transcription of 5S RNA, tRNA, and VAI RNA genes but not for the 7SK RNA and U6 small nuclear RNA genes. Transcription from the tRNA and VAI RNA genes in TFIIIC-depleted nuclear extracts can be restored by addition of purified TFIIIC. In contrast, restoration of 5S RNA gene transcription requires readdition of both TFIIIC and TFIIIA, indicating a promoter-independent interaction between these factors. Immunoprecipitation experiments demonstrate a tight association of all five polypeptides previously identified in the TFIIIC2 fraction, confirming the multisubunit structure of the human factor.
Emulating Empathy in Socially Assistive Robotics

Evidence from psychology indicates that perceived empathy has a host of beneficial effects on attitudes and social behavior. Empathy plays a key role in patient-centered therapy, because it implies the apprehension of another’s inner world and a joint understanding of emotions. This paper is a short survey of main issues relating to empathy that hold relevance to robotics. We focus on the existing literature on empathy in social psychology, and discuss its possible role of empathy in socially assistive robotics, along with possible methodologies for emulating and embodying empathy on robotic systems.
Solid-state Foaming of Nano–Clay-Filled Thermoset Foams with Shape Memory Properties

A solid-state process was used to produce epoxy foams with different contents of nano-clay (up to 10%wt). The foam properties were studied by means of numerous tests: X-ray analysis, dynamic mechanical analysis, mechanical tests (compression, flexure, indentation, stress relaxation). The straightening effect of the nano-clay filler was investigated and related to the loading conditions and the intrinsic properties of the resin matrix. Small and large foam samples were produced by changing the number of solid precursors during foaming. In the end, shape recovery tests showed that composite foams exhibit remarkably shape memory properties, at least at low filler contents.
COST-UTILITY ANALYSIS OF ADJUVANT THERAPIES FOR BREAST CANCER IN IRAN

Objectives: The aim of this study was to evaluate the cost-utility of Docetaxel with doxorubicin and cyclophosphamide (TAC) and 5-fluorouracil, doxorubicin, cyclophosphamide (FAC) in node-positive breast cancer patients in the south of Iran. Methods: A double blind study was done on a cohort of 100 patients suffering from breast cancer with node-positive over 8 months in the radiotherapy center of Namazi hospital, Shiraz-Iran. Health-related quality of life was assessed using questionnaire (QLQ-C30) from European Organization for Research and Treatment of Cancer (EORTC). QLQ-C30 scale scores were mapped to 15D and EuroQol 5D utilities to measure the quality-adjusted life-years (QALYs). Third party payer point of view was applied to measure and value the cost of treatments. Cost data were extracted from hospital and health insurance organizations. Robustness of the results was checked through a two way sensitivity analysis. Results: TAC was associated with higher deterioration in HRQoL during treatment and higher improvements over 4 months follow-up. On average, the cost of treatment per patient in TAC was 15 times higher than FAC (p < .001). In overall, TAC was resulted in lower QALYs and higher cost over study period. Conclusions: FAC was a dominant option versus TAC in short-term. The higher improvement in HRQoL over follow-up in TAC may not compensate the more intensive deterioration caused during treatment in short-term. The short time horizon of study may limit the generalizability of our findings and, hence, there is a need to conduct long-term economic evaluation studies whenever data is available to inform decision making.
Comparison between Data Obtained through Questionnaires and Interviews: Life-Style Habits of Pregnant Women

A random sample of pregnant women in the cities of Odense and Aalborg, Denmark, was taken as a part of a quasi-experimental study. The time period of the study was from October 1984 to March 1985. Out of 175 randomly selected pregnant women, 146 filled out the questionnaire in the 36th week of their pregnancy. The questionnaire was concerned with eating, smoking, and drinking habits before and during their pregnancy. These 146 pregnant women participated in an interview 3 weeks later where some of the same questions on the questionnaire were asked by the interviewer. In spite of the rather short interval between the two data collections, there were some differences in the answers given at the individual level. This is especially true for eating habits and estimated average drinking habits during pregnancy. No tendency was observed for a more frequent recalling of “less socially acceptable norms” in the questionnaire method of obtaining information. Lack of knowledge of the “true” classification is probably the main reason for the lack of stability in the answers given. This leads to some unavoidable misclassification in studies on self-reporting life style habits among pregnant women.