Miracle-dz/UniFAR-FTUs huggingface dataset:
Two cases of kidney transplantation‐associated thrombotic microangiopathy successfully treated with eculizumab

Transplantation‐associated thrombotic microangiopathy (TA‐TMA) is relatively rare and requires immediate intervention to avoid irreversible organ damage or death; however, consensus regarding the treatment approach is lacking. Atypical haemolytic uraemic syndrome (aHUS) is a rare disease caused by dysregulation of the alternative complement pathway resulting in TMA. aHUS is histologically similar to TA‐TMA; approximately 60% of TA‐TMA patients have complement dysregulation. Eculizumab, a humanized anti‐C5 monoclonal antibody, inhibits terminal membrane‐attack complex formation and TMA progression. Eculizumab has been successfully used to treat aHUS post‐transplant. We present two cases of kidney TA‐TMA due to unknown causes, suspected antibody‐mediated rejection, or calcineurin inhibitor (CNI)‐related toxicity that developed on day 1 or 2 post‐kidney transplantation. Low platelet count and haemoglobin level with red cell fragments were detected. Despite steroid pulse, plasma exchange (PE), and intravenous immunoglobulin therapy, TA‐TMA did not improve; therefore, eculizumab was administered despite no genetic testing. Laboratory data, including renal function, improved immediately. TA‐TMA treatment primarily involves PE initiation or CNI discontinuation; eculizumab can be used to safely treat TA‐TMA and then be ceased in the short term. Therefore, eculizumab administration might be beneficial for kidney TA‐TMA as early as the diagnosis of refractory to PE.
Cerebrospinal Fluid Rhinorrhea Secondary to Idiopathic Intracranial Hypertension: Long-term Outcomes of Endoscopic Repairs

Background Endoscopic endonasal repair of cerebrospinal fluid (CSF) rhinorrhea secondary to idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri or benign intracranial hypertension, has varying success rates, from 25–87%, with minimal morbidity. However, often these series have a relatively short-term follow-up. Given the pathophysiology of IIH, long-term follow-up is necessary to identify true CSF leak recurrence rates. Our investigation aimed to evaluate long-term outcomes in endoscopically repaired CSF leaks. Methods A retrospective chart review of all the patients with CSF rhinorrhea due to IIH who met inclusion criteria between 1996 and 2009. Outcome measures included the following: demographics, intracranial pressure, location of skull base defect, presence of encephalocele and/or meningoencephalocele, surgical repair technique, treatment with acetazolamide, whether a ventriculoperitoneal shunt was inserted, location of recurrence, history of meningitis or previous sinus surgery, and duration of follow-up. Results Thirty-two patients with a total of 44 skull base defects were reviewed over a mean follow-up of 10.2 years. The mean body mass index and intracranial pressure were 36.8 kg/m2 and 27.7 cm H2O, respectively. Seven patients (18%) required revision surgery at the same site or a distant site. We found no statistical significance that identified the recurrence risk in the outcome measurements most likely due to our small failure rate. However, early recurrences were noted to recur at the same repair site, whereas late recurrences were noted to recur at a distant site along the skull base. Conclusion IIH is an increasingly recognized entity treated by otorhinolaryngologists. We present the first long-term IIH CSF leak repair series. Long-term follow-up is necessary because delayed CSF leaks occur in this population.
Biochemical and histopathological effects on liver due to acute oral toxicity of aqueous leaf extract of Ecliptaalba on female Swiss albino mice

Background: Limited data is available about the toxicity of herbal remedies used for self-medication. Since a popular medicinal plant Ecliptaalba contains various bioactive molecules, the present study aimed to observe the biochemical and histological changes in liver associated with acute oral toxicity (LD50) of aqueous extract of E. alba (L.) Hassk. in female Swiss albino mice. Materials and Methods: For the acute oral toxicity study, the animals were divided into six groups of 6 mice each. Group– I was normal control and the treatment groups were administered aqueous leaf extract of E. alba orally at different doses of 500 mg (group – I),1750 mg (group–III), 2000 mg (group- IV), 2500 mg (group- V) and 3000 mg/ kg/b.wt. (group- VI) for seven consecutive days. The mice were sacrificed on the eighth day and blood was collected for the analysis of ALP (alkaline phosphatase), SGPT (serum glutamic pyruvic transferase), total protein and albumin. The liver was dissected, weighed, and processed for histopathological analysis. Results: The LD50 was found to be 2316.626 mg/kg /body weight in female mice. Serum SGPT, total protein and albumin increased in treated group- IV (P < 0.05), V (P < 0.01), and VI (P < 0.01) as compared to the control (group- I). ALP level significantly decreased in the treated group- IV (P < 0.05), V (P < 0.01) and VI (P < 0.01). Histopathological changes were observed at dose of 2000 mg (group- IV), 2500 mg (group- V) and 3000 mg (group- VI). Conclusion: It was concluded that oral administration of aqueous leaf extract of E. alba had detrimental effects on biochemical parameters and induced histopathological alterations in liver of female Swiss albino mice at doses higher than 2000 mg/kg/day indicating that its indiscriminate use should be avoided.
Risk Factors for Contralateral ACL Injury: A Single Institution Case–Control Study

Abstract Our purpose was to evaluate if there is any association between requiring contralateral anterior cruciate ligament (ACL) reconstruction and various: (1) demographics, (2) patient characteristics, and (3) surgery-specific factors. A prospectively collected database at a single institution was queried to find all patients who underwent primary ACL reconstruction between 2012 and 2014. We identified 312 primary ACL reconstruction patients with a mean age of 24 years and a mean follow-up of 3 years (range, 2–5 years). This cohort was compared with all those who had primary ACL reconstructions during the same time period without a contralateral procedure. We evaluated: (1) incidence, (2) demographic variables, (3) family history, (4) graft choice, (5) activity causing injury, and (6) mechanism of injury (contact versus noncontact). There were 16 patients (4.8%) with a mean age of 21 years and a mean follow-up of 3 years that required a contralateral reconstruction. More females required contralateral reconstruction when compared with the control cohort (p = 0.049). However, there was no difference in the mean age between the cohorts (p = 0.32). Those who underwent reconstruction using a tibialis anterior allograft were far more likely to require a contralateral reconstruction (p = 0.0002). Bone-tendon-bone patellar autograft (p = 0.16), hamstring autograft (p = 0.76), and hamstring allograft (p = 0.68) had similar incidences of contralateral ACL injury. Lacrosse was associated with higher risk of contralateral procedure (p = 0.03). Mechanism of injury had no association of contralateral reconstruction (p = 0.71). We found that those with the highest risk of contralateral ACL reconstruction following their index procedure were females, those with tibialis anterior allografts, and those who had their ipsilateral injury while playing lacrosse. These data may be used by practitioners when educating patients regarding their potential for requiring a contralateral reconstruction following their index procedure.
Experimental work on prosodically-marked information structure in selected african languages (afroasiatic and Niger-congo)

Data from lesser-studied languages help to delineat e parameters of typological variation. The paper pres ents experimental work on prosodic marking of informatio n structure in selected African languages. The langua ges investigated exemplify the cross-linguistic variety found in prosodic focus marking by either lacking marking of information structure by purely prosodic means, or by lowering pitch under focus. Neither prosodic markin g of information structure in general nor expansion of p itch range under focus can thus be considered language univers als. The review also gives evidence on how cross-linguistica lly comparable and highly interesting results are provi ded by adapting experimental methods and methodological st andards.
Promoter selectivity of Escherichia coli RNA polymerase sigmaF holoenzyme involved in transcription of flagellar and chemotaxis genes

The rpoF gene of Escherichia coli codes for the RNA polymerase sigmaF (or sigma28) subunit, which is involved in transcription of the flagellar and chemotaxis genes. Both sigmaF and sigma70 (the major sigma subunit in growing cells) were overexpressed, purified to homogeneity, and compared with respect to activity and specificity. The affinity of sigmaF to core RNA polymerase (E) is higher than that of sigma70, as measured by gel filtration high-pressure liquid chromatography. In an in vitro transcription system, the holoenzyme (E sigmaF) containing sigmaF selectively transcribed the flagellar and chemotaxis genes, all of which could not be transcribed by E sigma70. This strict promoter recognition property of sigmaF is similar to those of other stress response minor sigma subunits but different from those of the principal sigma subunits, sigma70 and sigma38. sigma70-dependent transcription in vitro is inhibited at high concentrations of all salts tested, showing maximum activity at 50 mM. In contrast, sigmaF-dependent transcription was maximum at 50 mM KCI and then decreased to negligible level at 300 mM; in the cases of potassium acetate and potassium glutamate, maximum transcription was between 200 and 300 mM. DNase I foot printing of the fliC and fliD promoters indicated that sigmaF alone is unable to bind DNA, but E sigmaF specifically recognizes -10 and -35 regions of the sigmaF-dependent promoters with rather long upstream protection. Alteration of the promoter structure after binding of E sigmaF was suggested.
Nephroblastoma in a Bovine Fetus

The right kidney of a bovine fetus aborted at approximately 6 months gestation was 15x19x10 cm, weighed 1.47 kg, and was not lobulated. The cut surface was pale pink and spongy. A diagnosis of nephroblastoma was made on the basis of epitheliallined tubular structures and cysts in a connective tissue stroma.
Stock market forecasting using hidden Markov model: a new approach

This paper presents hidden Markov models (HMM) approach for forecasting stock price for interrelated markets. We apply HMM to forecast some of the airlines stock. HMMs have been extensively used for pattern recognition and classification problems because of its proven suitability for modelling dynamic systems. However, using HMM for predicting future events is not straightforward. Here we use only one HMM that is trained on the past dataset of the chosen airlines. The trained HMM is used to search for the variable of interest behavioural data pattern from the past dataset. By interpolating the neighbouring values of these datasets forecasts are prepared. The results obtained using HMM are encouraging and HMM offers a new paradigm for stock market forecasting, an area that has been of much research interest lately.
Yeast-metal interactions: impact on brewing and distilling fermentations

[Abstract]: In brewing and distilling fermentations, key metal ions are magnesium and zinc, which act as co-factors for important glycolytic enzymes and also as modulators of yeast stress. In addition to their effects on enzymes, metal ions may have marked effects on stability and dynamics of cell membranes, leading to downstream effects on cell permeability and signalling systems. Occasionally, the bioavailability of certain key minerals may be limiting and this can adversely affect yeast fermentation processes. For example, zinc levels may decrease during mashing and wort boiling as the metal ion becomes complexed in precipitated trub. Consequently, zinc levels in wort may become compromised leading to impaired fermentation performance. This paper reviews previous work on the impact of magnesium and calcium on industrial yeasts and also describes the uptake and utilisation of zinc by brewing and distilling yeasts under conditions varying from deficit to oversupply. In addition, it discusses the impact of yeast-zinc interactions on the progress and efficiency of brewing and distilling fermentations, the status of cell membrane systems, and the influence of metals in governing yeast responses to environmental stress.
Power Spectral Analysis of Heart Rate and Arterial Pressure Variabilities as a Marker of Sympatho‐Vagal Interaction in Man and Conscious Dog

In 57 normal subjects (age 20–60 years), we analyzed the spontaneous beat-to-beat oscillation in R-R interval during control recumbent position, 90° upright tilt, controlled respiration (n = 16) and acute (n = 10) and chronic (n = 12) β-adrenergic receptor blockade. Automatic computer analysis provided the autoregressive power spectral density, as well as the number and relative power of the individual components. The power spectral density of R-R interval variability contained two major components in power, a high frequency at ∼0.25 Hz and a low frequency at ∼0.1 Hz, with a normalized low frequency: high frequency ratio of 3.6 ± 0.7. With tilt, the low-frequency component became largely predominant (90 ± 1%) withalow frequency: high frequency ratio of 21 ± 4. Acute β-adrenergic receptor blockade (0.2 mg/kg IV propranolol) increased variance at rest and markedly blunted the increase in low frequency and low frequency: high frequency ratio induced by tilt. Chronic β-adrenergic receptor blockade (0.6 mg/kg p.o. propranolol, t.i.d.), in addition, reduced low frequency and increased high frequency at rest, while limiting the low frequency: high frequency ratio increase produced by tilt. Controlled respiration produced at rest a marked increase in the high-frequency component, with a reduction of the low-frequency component and of the low frequency: high frequency ratio (0.7 ± 0.1); during tilt, the increase in the low frequency: high frequency ratio (8.3 ± 1.6) was significantly smaller. In seven additional subjects in whom direct high-fidelity arterial pressure was recorded, simultaneous R-R interval and arterial pressure variabilities were examined at rest and during tilt. Also, the power spectral density of arterial pressure variability contained two major components, with a relative low frequency: high frequency ratio at rest of 2.8 ± 0.7, which became 17 ± 5 with tilt. These power spectral density components were numerically similar to those observed in R-R variability. Thus, invasive and noninvasive studies provided similar results. More direct information on the role of cardiac sympathetic nerves on R-R and arterial pressure variabilities was derived from a group of experiments in conscious dogs before and after bilateral stellectomy. Under control conditions, high frequency was predominant and low frequency was very small or absent, owing to a predominant vagal tone. During a 9% decrease in arterial pressure obtained with IV nitroglycerin, there was a marked increase in low frequency, as a result of reflex sympathetic activation. Bilateral stellectomy prevented this low-frequency increase in R-R but not in arterial pressure autospectra, indicating that sympathetic nerves to the heart are instrumental in the genesis of low-frequency oscillations in R-R interval.
Continuous interprofessional coordination in perioperative work: an exploratory study

Abstract Coordination of perioperative work is challenging. Advancements in diagnostic and therapeutic possibilities have not been followed by similar advancements in the ability to coordinate care. In this paper, we report on a study that explored the nature of continuous coordination as practiced by perioperative staff in order to coordinate their own activities with respect to those of their colleagues. We conducted in-depth interviews (n = 14), and combined observations and focused interviews (n = 31) with perioperative staff (physicians, nurses, technicians, and cleaners) at a major university hospital in Norway. Data were analysed qualitatively with systematic text condensation. The results indicated that a surgical schedule was important for informing staff members about the cases and tasks they had been assigned. Staff also depended on ad hoc, explicit communication to ensure timeliness of particular perioperative activities. This, however, left little room for adjustments of other activities. Hence, to be able to proactively coordinate their own work some staff tried to predict future perioperative activities by observing the workplace, monitoring the surgical scheduling software for changes, and sharing their colleagues' progress updates and predictions. These findings could be important for those developing support for perioperative coordination.
Coverless Information Hiding Based on the Molecular Structure Images of Material

The traditional information hiding methods embed the secret information by modifying the carrier, which will inevitably leave traces of modification on the carrier. In this way, it is hard to resist the detection of steganalysis algorithm. To address this problem, the concept of coverless information hiding was proposed. Coverless information hiding can effectively resist steganalysis algorithm, since it uses unmodified natural stego-carriers to represent and convey confidential information. However, the state-of-the-arts method has a low hidden capacity, which makes it less appealing. Because the pixel values of different regions of the molecular structure images of material (MSIM) are usually different, this paper proposes a novel coverless information hiding method based on MSIM, which utilizes the average value of sub-image’s pixels to represent the secret information, according to the mapping between pixel value intervals and secret information. In addition, we employ a pseudo-random label sequence that is used to determine the position of sub-images to improve the security of the method. And the histogram of the Bag of words model (BOW) is used to determine the number of sub-images in the image that convey secret information. Moreover, to improve the retrieval efficiency, we built a multi-level inverted index structure. Furthermore, the proposed method can also be used for other natural images. Compared with the state-of-the-arts, experimental results and analysis manifest that our method has better performance in anti-steganalysis, security and capacity.
Eberlein oligomorphic groups

We study the Fourier--Stieltjes algebra of Roelcke precompact, non-archimedean, Polish groups and give a model-theoretic description of the Hilbert compactification of these groups. We characterize the family of such groups whose Fourier--Stieltjes algebra is dense in the algebra of weakly almost periodic functions: those are exactly the automorphism groups of $\aleph_0$-stable, $\aleph_0$-categorical structures. This analysis is then extended to all semitopological semigroup compactifications $S$ of such a group: $S$ is Hilbert-representable if and only if it is an inverse semigroup. We also show that every factor of the Hilbert compactification is Hilbert-representable.
A laboratory study of the effect of verbal rhetoric versus repetition when consumers are not directed to process advertising

Rhetorical figures appear frequently in the headlines of magazine ads. This paper examines the effect of repetition on ads containing two types of rhetorical figures: easyto-understand rhymes and challenging puns. The findings indicate that high levels of repetition may not be necessary when ad headlines contain such rhetorical figures, even under conditions where subjects are not directed to process the ads. Moreover, in contrast to some prior work, rhymes appear to be at least as effective as puns when consumers are free to ignore ads. Overall, the research supports the idea that getting the ad message right is probably more important than simply repeating the message a greater number of times.
Generation of stateless components from procedural programs for reuse in a distributed system

The paper describes the techniques and tools developed by the author to generate stateless components from existing COBOL programs for reuse as server nodes in a distributed system. The techniques are based on static analysis, dataflow slicing and interface reengineering. The tools are implemented as a series of batch transformation processes under a Windows-NT user interface. The purpose of the work is to reuse legacy software to fulfil old business functions in a new technical environment with a minimum of change, thereby saving the costs of redevelopment.
Predicting American Indian Adolescent Substance Use Trajectories Following Inpatient Treatment

This study examined the effects of psychopathological, peer, family, and cultural predictors of American Indian adolescents' drug use following inpatient treatment. Data regarding lifetime, 90 days prior to treatment, and 1-year posttreatment substance use were collected using interviews, questionnaires, and observations of 57 American Indian adolescents and their families. Trajectories of days-used measures were subjected to semiparametric trajectory analysis. Trajectories were then compared on baseline measures by using both univariate and multivariate logit regression techniques. The study sought to identify prerelease predictors of membership in post-inpatient treatment substance use trajectory groups. Findings provide insight into the unique and shared risk and protective factors relevant to American Indian adolescents' substance use outcomes. In particular, this study suggests that a combination of family management and American Indian traditional cultural practices in families serves as a potential target for interventions to reduce substance use in adolescence.
Intensifying online loyalty! The power of website quality and the perceived value of consumer/seller relationship

Purpose Stimulated by trends in group purchasing and online social communities, consumers are changing their shopping behavior and increasingly turning to websites for their shopping needs. The purpose of this paper is to investigate how website quality influences shopping websites to create value for the customer and promote loyalty among customers, as well as moderating effects of online shopping experience. Design/methodology/approach This study collected data from 275 respondents for testing against the proposed research model by means of the partial least squares (PLS) path modeling. ADANCO software was used to assess the reliability and validity of the measurement model, conduct an analysis of the goodness of model fit for the overall model, and test the hypotheses through structural modeling. Findings Empirical results demonstrate that system quality and electronic service quality (e-service quality) have a significant positive effect on the perceived value of consumer/seller relationship; the perceived value of the consumer/seller relationship has a significant positive effect on online loyalty; online shopping experience does not exert a moderating effect on the relationship between website quality and the perceived value of consumer/seller relationship. Originality/value This study applied the PLS path modeling approach using ADANCO variance-based structural equation modeling software to verify that website quality plays an important role in distinguishing a brand from other brands in e-tailing, making it an essential factor of a shopping website’s business success. This study further verified that the amount of previous online shopping experience a consumer has does not interfere with the positive influence that website quality exerts on the perceived value of the consumer/seller relationship. The above indicates that it is imperative for website managers to adopt online shopping experience of consumers as a market segmentation variable so as to enhance website quality, increase the perceived value of consumer-seller relationships, and win consumer loyalty.