Miracle-dz/UniFAR-FTUs huggingface dataset:
Mindfulness Plus Reflection Training: Effects on Executive Function in Early Childhood

Executive function (EF) skills are essential for academic achievement, and poverty-related stress interferes with their development. This pre-test, post-test, follow-up randomized-control trial assessed the impact of an intervention targeting reflection and stress reduction on children's EF skills. Preschool children (N = 218) from schools serving low-income families in two U.S. cities were randomly assigned to one of three options delivered in 30 small-group sessions over 6 weeks: Mindfulness + Reflection training; Literacy training; or Business as Usual (BAU). Sessions were conducted by local teachers trained in a literacy curriculum or Mindfulness + Reflection intervention, which involved calming activities and games that provided opportunities to practice reflection in the context of goal-directed problem solving. EF improved in all groups, but planned contrasts indicated that the Mindfulness + Reflection group significantly outperformed the BAU group at Follow-up (4 weeks post-test). No differences in EF were observed between the BAU and Literacy training groups. Results suggest that a brief, small-group, school-based intervention teaching mindfulness and reflection did not improve EF skills more than literacy training but is promising compared to BAU for improving EF in low-income preschool children several weeks following the intervention.
Oxidative stress-induced inflammatory responses and effects of N-acetylcysteine in bovine mammary alveolar cells

Bovine mastitis, an inflammation of the udder, results in reduced milk production and poor milk quality. Mastitis is usually, but not always, a response to pathogen infection. High milk yield can produce oxidative stress in the mammary tissue. High milk yield is also known to be associated with bovine mastitis. Thus, in the current study, we hypothesised that oxidative stress increases inflammatory responses in bovine mammary cells. To examine the hypothesis, we produced cellular oxidative stress and investigated resulting inflammatory responses in bovine mammary alveolar cells (MAC-T). To produce oxidative stress, cells were treated with the reactive oxygen species (ROS; e.g., superoxide anion)-producing agent, menadione (MD; 0–10 µm; 6 h). To ensure the ROS-induced responses, cells were pretreated with an antioxidant NAC (0–10 mm; 1 h). Results showed that MD elevated intracellular ROS levels and protein expression of cyclooxygenase-2 (COX-2), a biomarker of inflammation. Pretreatment of cells with NAC attenuated MD-induced COX-2 expression by scavenging intracellular ROS and enhancing intracellular glutathione levels. MD-induced COX-2 expression was mediated by activation of extracellular signal receptor-activated kinase 1/2 (ERK1/2), Akt, and nuclear factor-kappa B (NF-κB). NAC attenuated activation of these intracellular signalling molecules. Treatment of cells with pharmacological inhibitors for ERK1/2, Akt, and NF-κB confirmed the association of these signalling pathways in MD-induced COX-2 expression. These results support our hypothesis that oxidative stress, which is found in high-yielding dairy cows, can produce cellular inflammation in bovine mammary alveolar cells and prevention of oxidative stress can attenuate such pathological responses. This may be relevant for cases of clinical mastitis for which no pathogen can be isolated.
Modifications in DARPP‐32 phosphorylation pattern after repeated palatable food consumption undergo rapid habituation in the nucleus accumbens shell of non‐food‐deprived rats

In non‐food‐deprived rats a palatable meal induces a transient increase in dopamine output in the prefrontal cortex and nucleus accumbens shell and core; habituation to this response develops with a second palatable meal, selectively in the shell, unless animals are food‐deprived. A palatable meal also induces time‐dependent modifications in the dopamine and cAMP‐regulated phosphoprotein of Mr 32 000 (DARPP‐32) phosphorylation pattern that are prevented when SCH 23390, a selective dopamine D1 receptor antagonist, is administered shortly after the meal. This study investigated whether dopaminergic habituation in the shell had a counterpart in DARPP‐32 phosphorylation changes. In non‐food‐deprived rats, two consecutive palatable meals were followed by similar sequences of modifications in DARPP‐32 phosphorylation levels in the prefrontal cortex and nucleus accumbens core, while changes after the second meal were blunted in the shell. In food‐deprived rats two consecutive meals also induced similar phosphorylation changes in the shell. Finally, SCH 23390 administered shortly after the first palatable meal in non‐food‐deprived rats inhibited DARPP‐32 phosphorylation changes in response to the first meal, and prevented the habituation to a second meal in terms of dopaminergic response and DARPP‐32 phosphorylation changes. Thus, dopamine D1 receptor stimulation plays a role in the development of habituation.
QHREDGS Enhances Tube Formation, Metabolism and Survival of Endothelial Cells in Collagen-Chitosan Hydrogels

Cell survival in complex, vascularized tissues, has been implicated as a major bottleneck in advancement of therapies based on cardiac tissue engineering. This limitation motivates the search for small, inexpensive molecules that would simultaneously be cardio-protective and vasculogenic. Here, we present peptide sequence QHREDGS, based upon the fibrinogen-like domain of angiopoietin-1, as a prime candidate molecule. We demonstrated previously that QHREDGS improved cardiomyocyte metabolism and mitigated serum starved apoptosis. In this paper we further demonstrate the potency of QHREDGS in its ability to enhance endothelial cell survival, metabolism and tube formation. When endothelial cells were exposed to the soluble form of QHREDGS, improvements in endothelial cell barrier functionality, nitric oxide production and cell metabolism (ATP levels) in serum starved conditions were found. The functionality of the peptide was then examined when conjugated to collagen-chitosan hydrogel, a potential carrier for in vivo application. The presence of the peptide in the hydrogel mitigated paclitaxel induced apoptosis of endothelial cells in a dose dependent manner. Furthermore, the peptide modified hydrogels stimulated tube-like structure formation of encapsulated endothelial cells. When integrin αvβ3 or α5β1were antibody blocked during cell encapsulation in peptide modified hydrogels, tube formation was abolished. Therefore, the dual protective nature of the novel peptide QHREDGS may position this peptide as an appealing augmentation for collagen-chitosan hydrogels that could be used for biomaterial delivered cell therapies in the settings of myocardial infarction.
Bridging the gap between the foreland and hinterland I: Geochronology and plate tectonic geometry of Ordovician magmatism and terrane accretion on the Laurentian margin of New England

U-Pb dates on magmatic and detrital zircon from samples in the hinterland of the Taconic orogen place new constraints on the timing and plate tectonic geometry of terrane accretion and magmatic arc activity. The Moretown terrane, a Gondwanan-derived exotic block, extends from the Rowe Schist-Moretown Formation contact in the west to the Bronson Hill arc in the east. Arc-related plutonic and volcanic rocks formed above an east-dipping subduction zone under the western leading edge of the Moretown terrane from approximately 500 to 475 Ma, until collision with hyperextended distal fragments of Laurentia, represented by the Rowe Schist, at 475 Ma. Magmatic arc rocks formed during this interval are primarily located in the Shelburne Falls arc, although some are also located in the Bronson Hill arc to the east. Metasedimentary rocks in the Shelburne Falls arc contain detrital zircon derived from mixing of Gondwanan, Laurentian, and arc sources, suggesting that the Moretown terrane was proximal to Laurentia by 475 Ma. Explosive eruptions at 466 to 464 Ma preserved in the Barnard Volcanic Member of the Missisquoi Formation in Vermont and as ash beds in the Indian River Formation in the Taconic allochthons may record slab-breakoff of subducted lithosphere following collision of the Moretown terrane with distal Laurentian crustal fragments. Between 466 and 455 Ma a reversal in subduction polarity lead to a west-dipping subduction zone under Laurentia and the newly accreted Moretown terrane. Magmatic arc rocks in the Bronson Hill arc formed above this west-dipping subduction zone along the eastern trailing edge of the Moretown terrane at approximately 455 to 440 Ma. The western boundary of Ganderia in New England is east of the Bronson Hill arc, buried beneath Silurian and Devonian rocks deformed during the Acadian orogeny.
Understanding sleep-wake mechanisms and drug discovery

ABSTRACT Introduction: Although not discernible at first glance, sleep is a highly active and regulated brain state. Although we spend practically one third of our lifetimes in this stage, its importance is often taken for granted. Sleep loss can lead to disease, error and economic loss. Our understanding of how sleep is achieved has greatly advanced in recent years, and with that, the management of sleep disorders has improved. There is still room for improvement and recently many new compounds have reached clinical trials with a few being approved for commercial use. Areas covered: In this review, the authors make the case of sleep disorders as a matter of public health. The mechanisms of sleep transition are discussed emphasizing the wake and sleep promoting interaction of different brain regions. Finally, advances in pharmacotherapy are examined in the context of chronic insomnia and narcolepsy. Expert opinion: The orexinergic system is an example of a breakthrough in sleep medicine that has catalyzed drug development. Nevertheless, sleep is a topic still with many unanswered questions. That being said, the melanin-concentrating hormone system is becoming increasingly relevant and we speculate it will be the next target of sleep medication.
Integrative Health Coaching for Patients With Type 2 Diabetes

Purpose The purpose of this study was to evaluate the effectiveness of integrative health (IH) coaching on psychosocial factors, behavior change, and glycemic control in patients with type 2 diabetes. Methods Fifty-six patients with type 2 diabetes were randomized to either 6 months of IH coaching or usual care (control group). Coaching was conducted by telephone for fourteen 30-minute sessions. Patients were guided in creating an individualized vision of health, and goals were self-chosen to align with personal values. The coaching agenda, discussion topics, and goals were those of the patient, not the provider. Preintervention and postintervention assessments measured medication adherence, exercise frequency, patient engagement, psychosocial variables, and A1C. Results Perceived barriers to medication adherence decreased, while patient activation, perceived social support, and benefit finding all increased in the IH coaching group compared with those in the control group. Improvements in the coaching group alone were also observed for self-reported adherence, exercise frequency, stress, and perceived health status. Coaching participants with elevated baseline A1C (≥7%) significantly reduced their A1C. Conclusions A coaching intervention focused on patients’ values and sense of purpose may provide added benefit to traditional diabetes education programs. Fundamentals of IH coaching may be applied by diabetes educators to improve patient self-efficacy, accountability, and clinical outcomes.
Interferon-γ Upregulates Expression of IFP35 Gene in HeLa Cells via Interferon Regulatory Factor-1

Background Interferon-induced 35-kDa protein (IFP35) plays important roles in antiviral defense and the progression of some skin cancer diseases. It can be induced by interferon-γ (IFN-γ) in multiple human cells. However, the mechanisms by which IFN-γ contributes to IFP35 induction remain to be elucidated. Methods/Principal Findings We identified the transcription start sites of IFP35 by 5′ rapid amplification of cDNA ends (RACE) and cloned the promoter of IFP35. Sequence analysis and luciferase assays revealed two GC boxes and an IFN-stimulated response element (ISRE) in the 5′ upstream region of the transcription start sites, which were important for the basal transcription of IFP35 gene. Furthermore, we found that interferon regulatory factor 1 (IRF-1) and IRF-2 could bind to IFP35 promoter and upregulate endogenous IFP35 protein level. Depletion of endogenous IRF-1 by interfering RNA reduced the constitutive and IFN-γ-dependent expression of IFP35, whereas depletion of IRF-2 had little effect on IFN-γ-inducible IFP35 expression. Moreover, IRF-1 was recruited to the ISRE site in IFP35 promoter in IFN-γ treated HeLa cells, as demonstrated by electrophoretic mobility shift and chromatin immunoprecipitation assays. Conclusions/Significance These findings provide the first evidence that IRF-1 and IRF-2 are involved in constitutive IFP35 expression in HeLa cells, while IRF-1 also activates IFP35 expression in an IFN-γ-inducible manner. Our data therefore identified a new IRF-1 and IRF-2 target gene, which may expand our current understanding of the versatile functions of IRF-1 and IRF-2.
Coherence-weighted wiener filtering of somatosensory evoked potentials

In this paper, we present a Wiener filtering (WF) approach for extraction of somatosensory evoked potentials (SEPs) from the background electroencephalogram (EEG), with sweep-to-sweep variations in its signal power. To account for the EEG power variations, WF is modified by iteratively weighting the power spectrum using the coherence function. Coherence-weighted Wiener filtering (CWWF) is able to extract SEP waveforms, which have a greater level of detail as compared with conventional time-domain averaging (TDA). Using CWWF, the components of the SEP show significantly less variability. As such, CWWF should be useful as an important diagnostic tool able to detect minimal changes in the SEP. In an experimental study of cerebral hypoxia, CWWF is shown to be more responsive to detection of injury than WF or TDA.
A critical appraisal of the evidence for the role of splenectomy in adults and children with ITP

In primary chronic immune thrombocytopenia, long‐term response to splenectomy, with 60% of patients enjoying a treatment‐free life, is higher when compared with rituximab and similar to that with continuous thrombopoietin‐receptor agonists (TPO‐RA) administration. Splenectomy should continue to be offered to patients failing initial treatments in the absence of increased surgery‐related risks. The higher lifelong safety concerns with splenectomy (increased risk of infection, shared in part with rituximab, and of thrombosis, in common with TPO‐RA) and a mortality <1–2%, justify postponing surgery to the chronic phase, when spontaneous remissions are rarer. Patients failing initial treatment with corticosteroids/intravenous immunoglobulin may use TPO‐RA (or rituximab in selected cases) as a bridge to surgery if they prefer to reconsider splenectomy later on, in case of no response, adverse effects or if sustained response after stopping TPO‐RA is not attained. Special considerations apply in children aged ≤5 years, with splenectomy playing a marginal role. The recent approval of TPO‐RA in children may represent a major advancement.
Mechanical properties of cold-formed steel at elevated temperatures

This paper presents the mechanical properties data for cold-formed steel at elevated temperatures. The deterioration of the mechanical properties of yield strength (0.2% proof stress) and Young's modulus of elasticity are the primary properties in the design and analysis of cold-formed steel structures under fire. However, values of these properties at different temperatures are not well reported. Therefore, both steady and transient tensile coupon tests were conducted at different temperatures ranged approximately from 20 to 1000°C to obtain the mechanical properties of cold-formed steel structural material. This study included cold-formed steel of grade G550 and G500 with plate thickness of 1.0 and 1.9mm, respectively. Stress-strain curves at different temperatures are plotted. In addition, curves of elasticity modulus, yield strength obtained at different strain levels, ultimate strength and thermal elongation versus different temperatures are also plotted and compared with the results obtained from the Australian, British and European standards. The test results obtained from this study are also compared with the test results predicted by other researchers. A unified equation for yield strength and Young's modulus of cold-formed steel at elevated temperatures is proposed in this paper. It is shown that the proposed equation accurately predicted the yield strength and Young's modulus compared with the test results.
A Co-contextual Type Checker for Featherweight Java

This paper addresses compositional and incremental type checking for object-oriented programming languages. Recent work achieved incremental type checking for structurally typed functional languages through co-contextual typing rules, a constraint-based formulation that removes any context dependency for expression typings. However, that work does not cover key features of object-oriented languages: Subtype polymorphism, nominal typing, and implementation inheritance. Type checkers encode these features in the form of class tables, an additional form of typing context inhibiting incrementalization. In the present work, we demonstrate that an appropriate co-contextual notion to class tables exists, paving the way to efficient incremental type checkers for object-oriented languages. This yields a novel formulation of Igarashi et al.'s Featherweight Java (FJ) type system, where we replace class tables by the dual concept of class table requirements and class table operations by dual operations on class table requirements. We prove the equivalence of FJ's type system and our co-contextual formulation. Based on our formulation, we implemented an incremental FJ type checker and compared its performance against javac on a number of realistic example programs.
Shallow Marine Carbonate Dissolution and Early Diagenesis-Implications from an Incubation Study

Surface carbonate sediments from sites on the Bahamas Bank with different seagrass densities were incubated across a range of O2 delivery rates, to study the controls on metabolic carbonate dissolution in these sediments. The results confirmed the 1:1 ratio between the rates of O2 consumption and carbonate dissolution, demonstrating that microbial respiration was the ratelimiting step in metabolic carbonate dissolution. Furthermore, the dissolution we observed was actually net dissolution resulting from coupled dissolution and reprecipitation. This carbonate reprecipitation occurs on the time scale of days, and significantly alters the pore water dissolved inorganic carbon (DIC) stable isotopic composition. The carbonate reprecipitation/dissolution ratios observed here were similar to those reported in the literature for other sediments. Dissolution/ reprecipitation appeared to involve preferential dissolution of high magnesium calcite and reprecipitation of a carbonate phase with a Mg content that was only slightly lower than that of the dissolving phase. This result agrees with conclusions in the literature that “Ostwald ripening” may be responsible for this reprecipitation.
Coexistence of Terrestrial and Aerial Users in Cellular Networks

Enabling the integration of aerial mobile users into existing cellular networks would make possible a number of promising applications. However, current cellular networks have not been designed to serve aerial users, and hence an exploration of design parameters is required in order to allow network providers to modify their current infrastructure. As a first step in this direction, this paper provides an in-depth analysis of the coverage probability of the downlink of a cellular network that serves both aerial and ground users. We present an exact mathematical characterization of the coverage probability, which includes the effect of base stations (BSs) height, antenna pattern and drone altitude for various types of urban environments. Interestingly, our results show that the favorable propagation conditions that aerial users enjoy due to their altitude is also their strongest limiting factor, as it leaves them vulnerable to interference. This negative effect can be substantially reduced by optimizing the flying altitude, the base station height and antenna down-tilt angle. Moreover, lowering the base station height and increasing down-tilt angle are in general beneficial for both terrestrial and aerial users, pointing out a possible path to enable their coexistence.
An adaptive metabolic demand model for protein and amino acid requirements

The shortcomings of the metabolic implications of the current protein requirements model are reviewed, and an alternative model, validated with [1-13C]leucine balance results in human adults, is presented and evaluated in the context of defining protein requirements. The model identifies metabolic demands for amino acids as comprising a small fixed component and a variable adaptive component that is relatively insensitive to acute food or protein intake, but which changes slowly with a sustained change in intake, enabling N equilibrium to be achieved. The model accounts for the apparent low efficiency of utilisation of animal proteins in N balance studies and enables more realistic efficiency values to be measured within an experimental framework that takes account of the adaptive metabolic demand. However, the complex relationship between the adaptive metabolic demand and habitual level and quality of protein intake prevents prediction of protein quality by amino acid scoring, which can markedly underestimate actual values. In contrast to the current model, for fully adapted individuals risk of deficiency (i.e. negative N balance after complete adaptation) will only start to increase when intakes fall below the range of the true minimum requirements, i.e. a value that is currently unknown, but likely to be between 0·40 and 0·50 g/kg per d at the lower end of the reported distribution of requirements. At intakes greater than this with additional metabolic demands varying directly with intake, deficiency is only likely as a short-term response to a change to a lower intake within the adaptive range. Thus, for adults satisfying energy needs on most mixed human diets, intakes will be within the adaptive range, and N equilibrium ceases to be a useful indicator of nutritional adequacy of protein. In the context of prescriptive dietary guidelines it may be expedient to retain current values until the benefits (and any risks) of protein intakes within the adaptive range can be quantified. However, from a diagnostic perspective, indicators other than N balance need to be identified, since maintenance of N balance can no longer be used as a surrogate of adequate protein-related health.