Miracle-dz/UniFAR-FTUs huggingface dataset:
Surface properties of cross-linked polyethylene

This study reports on the loss of hydrophobicity of cross-linked polyethylene (XLPE) insulation. Specimens of steam cured XLPE cut from a nominal 28 kV/sub rms/ cable were immersed in saline solutions of varying conductivities from 5 to 10/sup 5/ /spl mu/S/cm over a wide range of temperatures from 0 to 98/spl deg/C. Specimens of XLPE were also left in air over the same temperature range. The hydrophobicity of the surface was determined by measuring the contact angle of a sessile drop of water. The contact angle decreased with increasing conductivity and increasing temperature of the saline solution. The time of immersion in the saline solution was extended up to 3,000 h until the reduced contact angle saturated at all the temperatures and all conductivities. The saturated values of the reduced contact angles and the time they took to reach it, depended on the temperature and the conductivity of the saline solution. In addition, the changes in the weight due to the uptake of water and the surface roughness of the XLPE specimens were determined during immersion. It will be shown that the decrease in the contact angle is related to the increased weight of the specimens and increased surface roughness.
The pattern of colorectal cancer surgery in Lithuania in 2005: do results meet expectations?

UNLABELLED The aim of this study was to expose the pattern of the surgical treatment of colorectal cancer in Lithuania in 2005. MATERIAL AND METHODS A retrospective analysis of 590 patients treated for colorectal cancer in the surgical departments of the Hospital of Lithuanian University of Health Sciences, the Institute of Oncology of Vilnius University, and Vilnius University Hospital Santariškių Klinikos in 2005 was performed. Demographic data, preoperative evaluation, postoperative complications assessed according to the Clavien-Dindo classification, the quality of pathological examination, and survival rates were analyzed. RESULTS A total of 590 patients, 269 women (45.6%) and 321 men (54.4%), were included in this study; the mean age was 68.3 years (SD, 11.2). Tumors were found in the colon of 274 patients (46.4%) and in the rectum of 316 patients (53.6%). An abdominal ultrasound scan was preoperatively performed in 516 patients (87.5%) and a chest x-ray in 316 patients (53.6%); 35 patients (5.9%) underwent abdominal computed tomography. Endorectal ultrasound was done in 99 (31.7%) cases. Neoadjuvant radiotherapy for T3 and T4 rectal tumors was applied in 42 cases (18.1%). Besides, 211 patients (35.8%) developed postoperative complications with an anastomotic leak emerging in 20 cases (3.4%). Death occurred in 7 patients (1.18%). On the average, 11.15 lymph nodes (SD, 6.02) were found in pathological specimens. Circumferential resection margins were assessed in 58 cases (18.4%). The overall 5-year survival rate was 52.06%. CONCLUSIONS The preoperative evaluation and the treatment of patients with colorectal cancer were not sufficiently consistent in Lithuania in 2005. In order to improve the treatment of colorectal cancer, standardization or the national database of colorectal cancer is necessary.
UvA-DARE ( Digital Academic Repository ) Why the phosphotransferase system of Escherichia coli escapes diffusion limitation

We calculated the implications of diffusion for the phosphoenolpyruvate:glucose phosphotransferase system (glucose-PTS) of Escherichia coli in silicon cells of various magnitudes. For a cell of bacterial size, diffusion limitation of glucose influx was negligible. Nevertheless, a significant concentration gradient for one of the enzyme species, nonphosphorylated IIA, was found. This should have consequences because the phosphorylation state of IIA is an important intracellular signal. For mammalian cell sizes we found significant diffusion limitation, as well as strong concentration gradients in many PTS components, and strong effects on glucose and energy signaling. We calculated that the PTS may sense both extracellular glucose and the intracellular free-energy state. We discuss i), that the effects of diffusion on cell function should prevent this highly effective bacterial system from functioning in eukaryotic cells, ii), that in the larger eukaryotic cell any similar chain of mobile group-transfer proteins can neither sustain the same volumetric flux as in bacteria nor transmit a signal far into the cell, and iii), that systems such as these may exhibit spatial differentiation in their sensitivity to different signals.
Novel mechanism of metabolic co-regulation coordinates the biosynthesis of secondary metabolites in Pseudomonas protegens

Metabolic co-regulation between biosynthetic pathways for secondary metabolites is common in microbes and can play an important role in microbial interactions. Here, we describe a novel mechanism of metabolic co-regulation in which an intermediate in one pathway is converted into signals that activate a second pathway. Our study focused on the co-regulation of 2,4-diacetylphloroglucinol (DAPG) and pyoluteorin, two antimicrobial metabolites produced by the soil bacterium Pseudomonas protegens. We show that an intermediate in DAPG biosynthesis, phloroglucinol, is transformed by a halogenase encoded in the pyoluteorin gene cluster into mono- and di-chlorinated phloroglucinols. The chlorinated phloroglucinols function as intra- and inter-cellular signals that induce the expression of pyoluteorin biosynthetic genes, pyoluteorin production, and pyoluteorin-mediated inhibition of the plant-pathogenic bacterium Erwinia amylovora. This metabolic co-regulation provides a strategy for P. protegens to optimize the deployment of secondary metabolites with distinct roles in cooperative and competitive microbial interactions. DOI: http://dx.doi. org/10.7554/eLife.22835. 001
Identification of consensus binding sites clarifies FMRP binding determinants

Fragile X mental retardation protein (FMRP) is a multifunctional RNA-binding protein with crucial roles in neuronal development and function. Efforts aimed at elucidating how FMRP target mRNAs are selected have produced divergent sets of target mRNA and putative FMRP-bound motifs, and a clear understanding of FMRP's binding determinants has been lacking. To clarify FMRP's binding to its target mRNAs, we produced a shared dataset of FMRP consensus binding sequences (FCBS), which were reproducibly identified in two published FMRP CLIP sequencing datasets. This comparative dataset revealed that of the various sequence and structural motifs that have been proposed to specify FMRP binding, the short sequence motifs TGGA and GAC were corroborated, and a novel TAY motif was identified. In addition, the distribution of the FCBS set demonstrates that FMRP preferentially binds to the coding region of its targets but also revealed binding along 3′ UTRs in a subset of target mRNAs. Beyond probing these putative motifs, the FCBS dataset of reproducibly identified FMRP binding sites is a valuable tool for investigating FMRP targets and function.
Template‐Assisted Self‐Assembly of Spherical Colloids into Complex and Controllable Structures

Colloidal aggregates with well‐controlled sizes, shapes, and structures have been fabricated by dewetting aqueous dispersions of monodispersed spherical colloids across surfaces patterned with two‐dimensional arrays of relief structures (or templates). The capability and feasibility of this approach have been demonstrated with the organization of polymer latex or silica beads into homo‐aggregates, including circular rings; polygonal and polyhedral clusters; and linear, zigzag, and spiral chains. It was also possible to generate hetero‐aggregates in the configuration of HF and H2O molecules that contained spherical colloids of different sizes, compositions, densities, functions, or a combination of these features. These uniform, well‐defined aggregates of spherical colloids are ideal model systems to investigate the aerodynamic, hydrodynamic, and optical properties of colloidal particles characterized by non‐spherical shapes and/or complex topologies. They can also serve as a new class of building blocks to generate hierarchically self‐assembled structures that are expected to exhibit interesting features valuable to areas ranging from condensed matter physics to photonics.
Mammalian Collection on Noah's Ark: The Effects of Beauty, Brain and Body Size

The importance of today's zoological gardens as the so-called “Noah's Ark” grows as the natural habitat of many species quickly diminishes. Their potential to shelter a large amount of individuals from many species gives us the opportunity to reintroduce a species that disappeared in nature. However, the selection of animals to be kept in zoos worldwide is highly selective and depends on human decisions driven by both ecological criteria such as population size or vulnerability and audience-driven criteria such as aesthetic preferences. Thus we focused our study on the most commonly kept and bred animal class, the mammals, and we asked which factors affect various aspects of the mammalian collection of zoos. We analyzed the presence/absence, population size, and frequency per species of each of the 123 mammalian families kept in the worldwide zoo collection. Our aim was to explain these data using the human-perceived attractiveness of mammalian families, their body weight, relative brain size and species richness of the family. In agreement with various previous studies, we found that the body size and the attractiveness of mammals significantly affect all studied components of the mammalian collection of zoos. There is a higher probability of the large and attractive families to be kept. Once kept, these animals are presented in larger numbers in more zoos. On the contrary, the relative mean brain size only affects the primary selection whether to keep the family or not. It does not affect the zoo population size or the number of zoos that keep the family.
Language identification from prosody without explicit features

Most current language identi(cid:12)cation (LID) systems make little or no use of prosodic information, despite the importance of prosody in LID by humans. The greatest obstacle has been that of (cid:12)nding an appropriate feature set which captures linguistically relevant prosodic information. The only system to attempt LID entirely on the basis of prosodic variables uses a set of over 200 features which are selected and combined in a task-speci(cid:12)c manner [12]. We apply a novel recurrent neural network model to the task of pairwise discrimination among languages. Network inputs are limited to delta-F0 and the (cid:12)rst di(cid:11)erence of the band limited amplitude envelope. Initial re-sults are based on all pairwise combinations of English, German, Japanese, Mandarin and Spanish, with 90 speakers per language.
Open Research Online The Open University’s repository of research publications

The Open University's repository of research publications and other research outputs Using suites of free refurbished computers may cost over four times more than buying and using 'state of the art' learning technologies Conference Item How to cite: Power, Tom (2006). Using suites of free refurbished computers may cost over four times more than buying and using 'state of the art' learning technologies. Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult the policies page. Using suites of ʻfreeʼ refurbished computers may cost over four times more than buying and using ʻstate of the artʼ learning technologies. The lack of adequately skilled and qualified teachers in developing nations, and the impact this has on the educational experiences of children within those nations constitutes an educational crisis comparable to the challenges global medicine faces with malaria or AIDS. The educational challenges, like many other aspects of development, are often most severe in rural areas (Mulkeen, 2005). It has been argued that such a challenge requires a new open-learning architecture for teacher professional development, situated in the context of the teachers daily practice, supported by the teachers peers, and accessing the full potential of new ICTs (Leach & Moon, 2006). There is substantial activity and expenditure to provide 'computers' for schools in the global south, but this tends to conform to a pattern identified here as 'thinking as usual' about ICT; a pattern often framed by assumptions about the costs of various forms of ICT. However, little is really known about what constitutes 'appropriate' ICT for education in poor rural communities (InfoDev 2005); even less about ICT as a vehicle for teacher professional development in such contexts. This paper applies a model of 'total costs of ownership' to a 'freely donated' ICT suite, and finds that the costs may well be much higher than alternative, more educationally empowering forms of ICT. Demonstrating that 'common-sense' assumptions about appropriate ICTs may not be correct, this paper seeks to clear the ground for establishing a framework for identifying appropriate ICTs for rural teacher and community development in the global south. Using suites of ʻfreeʼ refurbished computers may cost over four times more than buying and using ʻstate of the artʼ learning technologies. The lack of adequately skilled and qualified …
Reconciling Coherent Oscillation with Modulationof Irregular Spiking Activity in Selective Attention:Gamma-Range Synchronization between Sensoryand Executive Cortical Areas

In this computational work, we investigated gamma-band synchronization across cortical circuits associated with selective attention. The model explicitly instantiates a reciprocally connected loop of spiking neurons between a sensory-type (area MT) and an executive-type (prefrontal/parietal) cortical circuit (the source area for top-down attentional signaling). Moreover, unlike models in which neurons behave as clock-like oscillators, in our model single-cell firing is highly irregular (close to Poisson), while local field potential exhibits a population rhythm. In this “sparsely synchronized oscillation” regime, the model reproduces and clarifies multiple observations from behaving animals. Top-down attentional inputs have a profound effect on network oscillatory dynamics while only modestly affecting single-neuron spiking statistics. In addition, attentional synchrony modulations are highly selective: interareal neuronal coherence occurs only when there is a close match between the preferred feature of neurons, the attended feature, and the presented stimulus, a prediction that is experimentally testable. When interareal coherence was abolished, attention-induced gain modulations of sensory neurons were slightly reduced. Therefore, our model reconciles the rate and synchronization effects, and suggests that interareal coherence contributes to large-scale neuronal computation in the brain through modest enhancement of rate modulations as well as a pronounced attention-specific enhancement of neural synchrony.
Liver injury induced by the Japanese herbal drug kamishoyosan.

Traditional Japanese herbal medicines (kampo medicines) are currently used for various purposes, and they have even shown effectiveness in some cases that were resistant to conventional treatments. Most general practitioners in Japan consider kampo medicine to be safe and less harmful than many conventional medications. As described in this case report, however, kamishoyosan given to a 48-year-old woman for menopausal disturbance appeared to induce liver injury.
Merkle Puzzles are Optimal

We prove that every key exchange protocol in the random oracle model in which the honest users make at most n queries to the oracle can be broken by an adversary making O(n^2) queries to the oracle. This improves on the previous Omega(n^6) query attack given by Impagliazzo and Rudich (STOC '89). Our bound is optimal up to a constant factor since Merkle (CACM '78) gave an n query key exchange protocol in this model that cannot be broken by an adversary making o(n^2) queries.
Outcome of Primary Percutaneous Intervention in Patients With Infarct-Related Coronary Artery Ectasia

Data related to the incidence and clinical outcome of acute myocardial infarction (AMI) in patients with preexisting coronary artery ectasia (CAE) are limited. We assessed whether infarct-related artery ectasia (EIRA) indicates an untoward clinical outcome in patients with AMI undergoing primary percutaneous coronary intervention (pPCI). Consecutive patients (n = 643) who presented with AMI and were treated with pPCI were analyzed retrospectively; 31 patients (4.8%) had EIRA. Patients who had EIRA were significantly younger and had higher incidence of hypertension, previous stroke, smoking, inferior wall AMI, and Killip score >1. Infarct-related artery ectasia was more frequent in the right coronary artery (RCA). Impaired epicardial arterial flow, thrombus burden score of infarct-related artery (IRA), impaired Thrombolysis in Myocardial Infarction (TIMI) Myocardial Perfusion Grade, and distal embolization were significantly higher whereas ST-segment resolution and collateral vascular development were significantly lower in patients with EIRA. Infarct-related artery ectasia was an independent predictor of adverse outcome (odds ratio: 0.197; 95% confidence interval [CI]: 0.062-0.633; P = .006).
Validation of the Stanmore percentage of normal shoulder assessment

Background and Purpose: The Stanmore Percentage of Normal Shoulder Assessment (SPONSA) is a patient-reported outcome measure (PROM). The score assesses pain, range of movement, strength, stability and function of the shoulder. The aim of this work was to formally validate the SPONSA. Materials and Methods: Validation of this score was carried out by measuring reproducibility, construct validity and sensitivity to change. Time to completion was also recorded. The Oxford Shoulder Score (OSS) and Constant Score (CS) were used for comparison. These assessments were performed with 61 individuals undergoing shoulder interventions. Results: There was excellent preoperative reproducibility in both intra- and inter-observer groups. The SPONSA had a 0.79 correlation with the OSS and 0.78 with the CS. The overall effect size of the SPONSA was 0.72, which was comparable to OSS (0.65) and greater than CS (0.34), implying equal or better sensitivity to change. Conclusions: The SPONSA is practical and quick to perform and also a reproducible and a sensitive instrument. This simple PROM is a commendable addition to the existing validated scoring methods for the shoulder. Level of Evidence: I; testing of previously developed diagnostic criteria on consecutive patients (with universally applied reference “gold” standard).
Why physicians need to look more closely at the use of complementary and alternative medicine by multiple sclerosis patients

With the aim of contributing to the knowledge of attitudes, patterns and motivations for the use of complementary and alternative medicine (CAM) for multiple sclerosis (MS), 109 MS outpatients, or their close relative in cases of mental status impairment, were interviewed using a semi‐structured questionnaire. The main results are: (i) 35.7% used at least one CAM at least once; (ii) homeopathy and diets were the most common; (iii) 39.4% showed a positive attitude towards CAM; (iv) a perceived benefit was recorded in 61.5% of cases; (v) the referral source was a physician in only 12.8% of cases; (vi) caring neurologist was not consulted in 82% and generalist was not consulted in 67% of cases; (vii) of 61 CAM interventions, 21 were expected to be disease‐modifying and 40 symptomatic; (viii) CAM negatively influenced compliance with conventional medical management in very few cases (2/39); (ix) a higher expanded disability status scale (EDSS) was observed in CAM users; and (x) in those who used CAM during last 3 years (21.1%), the approximate mean cost per year per person was 483 €. In Italy, the use of CAM in MS is widespread but costly. This study has provided further baseline data on which to assess trends in CAM use and has highlighted issues for patients and conventional doctors about the use of CAM to deal with health problems. More research into the implications of concurrent use of CAM with conventional medicine on public health care is required.
Contextual Gaussian Process Bandit Optimization

How should we design experiments to maximize performance of a complex system, taking into account uncontrollable environmental conditions? How should we select relevant documents (ads) to display, given information about the user? These tasks can be formalized as contextual bandit problems, where at each round, we receive context (about the experimental conditions, the query), and have to choose an action (parameters, documents). The key challenge is to trade off exploration by gathering data for estimating the mean payoff function over the context-action space, and to exploit by choosing an action deemed optimal based on the gathered data. We model the payoff function as a sample from a Gaussian process defined over the joint context-action space, and develop CGP-UCB, an intuitive upper-confidence style algorithm. We show that by mixing and matching kernels for contexts and actions, CGP-UCB can handle a variety of practical applications. We further provide generic tools for deriving regret bounds when using such composite kernel functions. Lastly, we evaluate our algorithm on two case studies, in the context of automated vaccine design and sensor management. We show that context-sensitive optimization outperforms no or naive use of context.
Efficiency trends and limits from comprehensive microarchitectural adaptivity

Increasing demand for power-efficient, high-performance computing requires tuning applications and/or the underlying hardware to improve the mapping between workload heterogeneity and computational resources. To assess the potential benefits of hardware tuning, we propose a framework that leverages synergistic interactions between recent advances in (a) sampling, (b) predictive modeling, and (c) optimization heuristics. This framework enables qualitatively new capabilities in analyzing the performance and power characteristics of adaptive microarchitectures. For the first time, we are able to simultaneously consider high temporal and comprehensive spatial adaptivity. In particular, we optimize efficiency for many, short adaptive intervals and identify the best configuration of 15 parameters, which define a space of 240B point. With frequent sub-application reconfiguration and a fully reconfigurable hardware substrate, adaptive microarchitectures achieve bips3/w efficiency gains of up to 5.3x (median 2.4x) relative to their static counterparts already optimized for a given application. This 5.3x efficiency gain is derived from a 1.6x performance gain and 0.8x power reduction. Although several applications achieve a significant fraction of their potential efficiency with as few as three adaptive parameters, the three most significant parameters differ across applications. These differences motivate a hardware substrate capable of comprehensive adaptivity to meet these diverse application requirements.