Miracle-dz/UniFAR-FTUs huggingface dataset:
Pan-phosphatidylinositol 3-kinase inhibition with buparlisib in patients with relapsed or refractory non-Hodgkin lymphoma

Activation of the phosphatidylinositol 3-kinase/mechanistic target of rapamycin pathway plays a role in the pathogenesis of non-Hodgkin lymphoma. This multicenter, open-label phase 2 study evaluated buparlisib (BKM120), a pan-class I phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or refractory non-Hodgkin lymphoma. Three separate cohorts of patients (with diffuse large B-cell lymphoma, mantle cell lymphoma, or follicular lymphoma) received buparlisib 100 mg once daily until progression, intolerance, or withdrawal of consent. The primary endpoint was overall response rate based on a 6-month best overall response by cohort; secondary endpoints included progression-free survival, duration of response, overall survival, safety, and tolerability. Overall, 72 patients (26 with diffuse large B-cell lymphoma, 22 with mantle cell lymphoma, and 24 with follicular lymphoma) were treated. The overall response rates were 11.5%, 22.7%, and 25.0% in patients with diffuse large B-cell lymphoma, mantle cell lymphoma, and follicular lymphoma, respectively; two patients (one each with diffuse large B-cell lymphoma and mantle cell lymphoma) achieved a complete response. The most frequently reported (>20%) adverse events of any grade in the population in which safety was studied were hyperglycemia, fatigue, and nausea (36.1% each), depression (29.2%), diarrhea (27.8%), and anxiety (25.0%). The most common grade 3/4 adverse events included hyperglycemia (11.1%) and neutropenia (5.6%). Buparlisib showed activity in relapsed or refractory non-Hodgkin lymphoma, with disease stabilization and sustained tumor burden reduction in some patients, and acceptable toxicity. Development of mechanism-based combination regimens with buparlisib is warranted. (This study was funded by Novartis Pharmaceuticals Corporation and registered with ClinicalTrials.gov number, NCT01693614).
A NUMERICAL MODEL OF THE SLOWLY VARYING TROPICAL CYCLONE IN ISENTROPIC COORDINATES

Abstract A diagnostic axisymmetric model in isentropic coordinates is developed to study the effect of differential heating on the dynamics and energetics of the steady-state tropical cyclone. From the thermal forcing specified by various heating distributions, slowly varying solutions for the mass and momentum fields are obtained by an iterative technique. The theory of available potential energy for open systems is utilized to study the energy budget for the hurricane. In the slowly varying state, the gain of available potential energy by diabatic heating and lateral boundary processes balances the conversion of potential to kinetic energy that, in turn, offsets frictional dissipation. For a domain of radius 500 km, the boundary flux of available potential energy is about 40 percent of the generation by diabatic heating. For a domain of radius 1000 km, however, the boundary flux is about 15 percent of the generation. Horizontal and vertical mixing are studied through the use of constant exchange coeffic.
Global Culture—Myth or Reality? Perceptions of “National Cultures” in a Global Corporation

The literature argues that in global business communication the concept of “national culture(s)” is becoming obsolete because globalization leads to cultural convergence. This article argues that “national cultures” are not obsolete in global organizations. Two focus group interviews were conducted in a global corporation using folk perceptions as a framework. Employees were asked to discuss their work practices and agreed that uniform standards could not be used across cultures. The article concludes that, despite globalization, we do not see evidence of cultural assimilation in global employees’ work practices, but rather that stereotypes of national cultures are used to provide orientation.
3D Finite Element Simulation of Graphene Nano-Electro-Mechanical Switches

In this paper, we report the finite element method (FEM) simulation of double-clamped graphene nanoelectromechanical (NEM) switches. Pull-in and pull-out characteristics are analyzed for graphene NEM switches with different dimensions and these are consistent with the experimental results. This numerical model is used to study the scaling nature of the graphene NEM switches. We show the possibility of achieving a pull-in voltage as low as 2 V for a 1.5-μm-long and 3-nm-thick nanocrystalline graphene beam NEM switch. In order to study the mechanical reliability of the graphene NEM switches, von Mises stress analysis is carried out. This analysis shows that a thinner graphene beam results in a lower von Mises stress. Moreover, a strong electrostatic force at the beam edges leads to a mechanical deflection at the edges larger than that around the center of the beam, which is consistent with the von Mises stress analysis.
COMPARATIVE SEISMIC RISK STUDIES FOR GERMAN EARTHQUAKE REGIONS DAMAGE AND LOSS ASSESSMENT FOR THE CITY OF COLOGNE

In current research quantifying loss potentials for German city regions basic tools for GIS-based seismic risk assessment technologies have been developed and applied to the building stock and regional particularities of German earthquake regions. Different study areas with comparable levels of seismic hazards were investigated, but they had varying numbers of inhabitants and degrees of urbanization. This paper focuses on the case study of Cologne as an example for a larger city, and is related to results of the German Research Network Natural Disasters DFNK-project [1]. Seismic risk maps were prepared for different EMSintensities. The impact of model assumptions and the step-wise refinement of input variables on the distribution of expected building damage are recognized as leading to different risk maps. Furthermore, the zones of higher risk are identified. An integrated approach combining data from official and insurance statistics was used to develop an inventory of exposed values in Cologne. A loss estimation procedure was applied converting results of refined vulnerability and damage assignments into mean damage ratios for the 370 municipalities. Results are available for different scenario events (with return periods TR between 475 and 10.000 years). Results support the prognosis that in the case of strong earthquakes the loss might rise to maximum values between 25 and 30 billion US $ for the city, and up to 60 billion US $ (and still higher) if all whole surrounded regions are considered. This estimate is consistent with previous lower bound estimates by Allmann et al. [2]. The extent to which extent the loss varies due to scenario event, local site effects, the vulnerability of building types, the assigned asset, and the implied correlation between damage and loss is also shown.
Forming Shapes to Bodies: Design for Manufacturing in the Prosthetic Instruments

Moving new DMIs from the research lab to professional artistic contexts places new demands on both their design and manufacturing. Through a discussion of the Prosthetic Instruments, a family of digital musical instruments we designed for use in an interactive dance performance, we discuss four different approaches to manufacturing – artisanal, building block, rapid prototyping, and industrial. We discuss our use of these different approaches as we strove to reconcile the many conflicting constraints placed upon the instruments’ design due to their use as hypothetical prosthetic extensions to dancers’ bodies, as aesthetic objects, and as instruments used in a professional touring context. Experiences and lessons learned during the design and manufacturing process are discussed in relation both to these manufacturing approaches as well as to Bill Buxton’s concept of artist-spec design.
Sparseness of the neuronal representation of stimuli in the primate temporal visual cortex.

1. To analyze the selectivity and the sparseness of firing to visual stimuli of single neurons in the primate temporal cortical visual area, neuronal responses were measured to a set of 68 visual stimuli in macaques performing a visual fixation task. The population of neurons analyzed had responses that occurred primarily to faces. The stimuli included 23 faces, and 45 nonface images of real-world scenes, so that the function of this brain region could be analyzed when it was processing natural scenes. 2. The neurons were selected to meet the previously used criteria of face selectivity by responding more than twice as much to the optimal face as to the optimal nonface stimulus in the set. Application of information theoretic analyses to the responses of these neurons confirmed that their responses contained much more information about which of 20 face stimuli had been seen (on average 0.4 bits) than about which (of 20) nonface stimuli had been seen (on average 0.07 bits). 3. The sparseness of the representation of a scene or object provided by each of these neurons (which can be thought of as the proportion of stimuli to which the neuron responds, and which is fundamental to understanding the network operation of the system) can be defined as [formula: see text] where ri is the firing rate to the ith stimulus in the set of n stimuli. The sparseness has a maximal value of 1.0. It was found that the sparseness of the representation of the 68 stimuli by each neuron had an average across all neurons of 0.65. This indicates a rather distributed representation. 4. If the spontaneous firing rate was subtracted from the firing rate of the neuron to each stimulus, so that the changes of firing rate, i.e., the responses of the neurons, were used in the sparseness calculation, then the "response sparseness" had a lower value, with a mean of 0.33 for the population of neurons, or 0.60 if calculated over the set of faces. 5. Multidimensional scaling to produce a stimulus space represented by this population of neurons showed that the different faces were well separated in the space created, whereas the different nonface stimuli were grouped together in the space. 6. The information analyses and multidimensional scaling provided evidence that what was made explicit in the responses of these neurons was information about which face had been seen. (ABSTRACT TRUNCATED AT 400 WORDS)
Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix

Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59‐year‐old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc.
Caring about tomorrow: future orientation, environmental attitudes and behaviors

Almost any pro-environmental behavior arouses a temporal conflict, as protecting long-term interests requires the sacrifice of short-term ones. Similarly, many health promoting behaviors may involve present discomfort for the sake of future well-being. In both contexts, health or environmental, developed future orientation (FO) is required to succeed in achieving long-term goals. This study examined FO, measured by Zimbardo's time perspective inventory (ZTPI), in both contexts in a sample of 333 Israeli undergraduate students. FO correlated positively with health concern and behavior. In the environmental context, the results were different. Highly future-oriented (according to ZTPI) respondents did not express stronger pro-environmental attitudes, and their willingness to sacrifice for the sake of the environment was significantly lower. They adopted pro-environmental behavior only if it coincided with their personal benefit. The study suggests that the future of the environment may not be perceived in the same way as people's personal future health. The implications for environmental education and communication are discussed.
Clinical and methodological issues in measuring rate of forgetting with the Verbal Selective Reminding Test

This study used a verbal selective reminding paradigm to examine rate of forgetting in a sample of 287 normal adults (age range = 18-91 years). Results revealed that older subjects performed below levels obtained by younger ones on several measures of acquisition and delayed recall. Data also revealed very modest differences in rate of forgetting. However, the pattern of differences in forgetting varied, depending on the index used to measure what was stored during acquisition. Older adults obtained marginally higher forgetting rates using 2 of 3 indexes but exhibited less forgetting when another index was used. Data suggested that using the Trial 12 score for long-term storage (Buschke & Fuld, 1974) to calculate forgetting may be more valid from a practical and theoretical standpoint than using other learning measures
Who benefits from more tasks? Older versus younger workers

Purpose – Although a substantial body of research has examined the effects of job characteristics on job attitudes, there is a paucity of work on individual difference moderators of these relationships. Based in selective optimization with compensation theory and socio-emotional selectivity theory, the purpose of this paper is to show that age moderated the relationship between task variety and two key job attitudes, job satisfaction and engagement. Design/methodology/approach – Data were collected through self-report questionnaires (n=152), using a time-lagged design with two waves (two to three weeks between T 1 and T 2). Findings – The authors found that task variety had a stronger relationship with job satisfaction and work engagement for younger workers compared to older workers. Research limitations/implications – Although there was good age variance in the sample, it had fewer late-career workers and more workers who are in their early and mid-career. Practical implications – To have workers of all.
Review of equine acute-phase proteins.

Plasma concentrations of acute-phase proteins (APPs) increase during the acute-phase response to every process that leads to tissue damage (e.g., infections, trauma, surgery, and neoplasia). Measurements of APPs may be useful for diagnosing the presence of inflammation and tissue damage, prognostication, monitoring the effect of the therapy and the occurrence of post-operative complications or relapse, and monitoring herd health. APPs are potentially valuable adjuvants to clinical assessment of a patient. Author’s address: Department of Large Animal Sciences (Large Animal Surgery), Faculty of Life Sciences, University of Copenhagen, Dyrlaegevej 48, DK-1870 Frederiksberg C, Copenhagen, Denmark; e-mail: stj@life.ku. dk. © 2007 AAEP.
HIV Vaccine Development: Tools and Knowledge

This eBook is an Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. However, users who aim to disseminate and distribute copies of this book as a whole must not seek monetary compensation for such service (excluded OMICS Group representatives and agreed collaborations). After this work has been published by OMICS Group, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. Statements and opinions expressed in the book are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Introduction One of the greatest ideal aspirations of science and health organizations is the discovery of a safe and effective HIV vaccine. The hope in developing HIV vaccines increased after results obtained with the RV144 human clinical trial using recombinant poxvirus vector carrying HIV-1 envelope (env), gag and protease genes as priming and recombinant Env proteins as booster [1]. The RV144 trial provided modest but unprecedented 31% of protection against HIV acquisition in a low-risk population and the immune correlates hypothesized that binding antibodies against the variable (V1 and V2) region of HIV-1 envelope contributed to protection against HIV-1 infection [1,2]. Binding antibodies were associated with antibody dependent cellular cytotoxicity mechanism and brought to light immune functions not previously associated with HIV prevention. Since the identification of HIV as the pathogenic agent of acquired immunodeficiency syndrome (AIDS) for more than 30 years, no vaccine achieved licensure. The epidemic caused by HIV/AIDS is far from being controlled and is continuously growing in some parts of the world. The infection that was initially associated with homosexual male behavior in 1980´s today affects both genders equally, with children being 1% of total infected people. An effective preventive vaccine should induce protective immune response in …
Absolute dimensions of eclipsing binaries - XXVII. V1130 Tauri: a metal-weak F-type system, perhaps with preference for Y = 0.23–0.24

Context. Double-lined, detached eclipsing binaries are our main source for accurate stellar masses and radii. This paper is the first in a series with focus on the upper half of the main-sequence band and tests of 1-2 Mevolutionary models. Aims. We aim to determine absolute dimensions and abundances for the detached eclipsing binary V1130 Tau, and to perform a de- tailed comparison with results from recent stellar evolutionary models. Methods. uvby light curves and uvbyβ standard photometry have been obtained with the Stromgren Automatic Telescope, and high-resolution spectra have been acquired at the FEROS spectrograph; both are ESO, La Silla facilities. We have applied the Wilson-Devinney model for the photometric analysis, spectroscopic elements are based on radial velocities measured via broad- ening functions, and (Fe/H) abundances have been determined from synthetic spectra and uvby calibrations. Results. V1130 Tau is a bright (mV = 6.56), nearby (71 ± 2 pc) detached system with a circular orbit (P = 0. d 80). The components are deformed with filling factors above 0.9. Their masses and radii have been established to 0.6-0.7%. We derive a (Fe/H) abundance of −0.25 ± 0.10. The measured rotational velocities, 92.4 ± 1.1 (primary) and 104.7 ± 2.7 (secondary) km s −1 , are in fair agreement with synchronization. The larger 1.39 Msecondary component has evolved to the middle of the main-sequence band and is slightly cooler than the 1.31 Mprimary. Yonsai-Yale, BaSTI, and Granada evolutionary models for the observed metal abundance and a "normal" He content of Y = 0.25−0.26, marginally reproduce the components at ages between 1.8 and 2.1 Gyr. All such models are, however, systematically about 200 K hotter than observed and predict ages for the more massive component, which are systematically higher than for the less massive component. These trends can not be removed by adjusting the amount of core overshoot or envelope convection level, or by including rotation in the model calculations. They may be due to proximity effects in V1130 Tau, but on the other hand, we find excellent agreement for 2.5-2.8 Gyr Granada models with a slightly lower Y of 0.23-0.24. Conclusions. V1130 Tau is a valuable addition to the very few well-studied 1-2 Mbinaries with component(s) in the upper half of the main-sequence band, or beyond. The stars are not evolved enough to provide new information on the dependence of core overshoot on mass (and abundance), but might - together with a larger sample of well-detached systems - be useful for further tuning of the helium enrichment law. Analyses of such systems are in progress.
Oral Contraceptive Pills and Clinical Otosclerosis

Clinical otosclerosis is a familial disease which is more frequent among women in their reproductive years. The condition usually is aggravated by pregnancy. Endocrinologic variables may influence the time of onset and the course of the disease. It is suspected that oral contraceptives (OCs) might stimulate the onset of the disease. Six hundred nulliparous women between the ages of 16 and 30, who used a variety of OCs for 12–36 months, were examined. The hearing of these women was thoroughly investigated. The first audiometric examination of the 600 women revealed three cases (0.5%) of clinical otosclerosis. This incidence is equal to that of the population as a whole, but lower than the incidence found in previously parous women. Audiometric examinations were normal in the remaining 597 women, and repeated examinations revealed no new cases of clinical otosclerosis, despite continuous OC use.
Educational quality differences in a middle-income country: the urban-rural gap in Malaysian primary schools

Shortcomings of educational quality in rural schools remain a key focus in the literature related to developing countries. This paper studies whether rural primary schools in Malaysia, an upper middle-income developing country, are still experiencing lower levels of educational resources, school climate, school leadership, and parental involvement than their urban counterparts. A survey questionnaire, containing items related to these 4 factors, was distributed to teachers in the 2 school locations. In the study, 1183 teachers from 63 rural schools and 1367 teachers from 60 urban schools were involved. Due to the hierarchical nature of the data, multilevel modelling analysis was used for data analysis. Open-ended questions were analyzed using text analysis. Findings showed that generally no differences between urban and rural schools in educational quality as perceived by teachers were found, which contradicts previous studies. Nevertheless, results did show that rural teachers perceived lower levels of school climate.