Miracle-dz/UniFAR-FTUs huggingface dataset:
A General Framework for Asynchronous Communication

We study a problem of sequential frame detection in an asynchronous framework, where a single frame of length <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> slots is transmitted uniformly in a large interval of known size <inline-formula> <tex-math notation="LaTeX">$A$ </tex-math></inline-formula> slots. In this setup, we seek to characterize the scaling needed of <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> and the channel (input) parameters for asynchronous optimal frame synchronization. We note that the framework permits a natural trade-off between <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>, where <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula> is the synchronization threshold of the channel (usually parameterized by the channel input). We present a general framework that permits this trade-off and then characterize the scaling needed of both <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula> as a function of the asynchronism period <inline-formula> <tex-math notation="LaTeX">$A$ </tex-math></inline-formula>. Finally, we apply our results to the AWGN channel as an illustration.
Composition and structure of photosystem I in the moss Physcomitrella patens

Recently, bryophytes, which diverged from the ancestor of seed plants more than 400 million years ago, came into focus in photosynthesis research as they can provide valuable insights into the evolution of photosynthetic complexes during the adaptation to terrestrial life. This study isolated intact photosystem I (PSI) with its associated light-harvesting complex (LHCI) from the moss Physcomitrella patens and characterized its structure, polypeptide composition, and light-harvesting function using electron microscopy, mass spectrometry, biochemical, and physiological methods. It became evident that Physcomitrella possesses a strikingly high number of isoforms for the different PSI core subunits as well as LHCI proteins. It was demonstrated that all these different subunit isoforms are expressed at the protein level and are incorporated into functional PSI–LHCI complexes. Furthermore, in contrast to previous reports, it was demonstrated that Physcomitrella assembles a light-harvesting complex consisting of four light-harvesting proteins forming a higher-plant-like PSI superstructure.
Design of 24-GHz 0.8-V 1.51-mW Coupling Current-Mode Injection-Locked Frequency Divider With Wide Locking Range

A 0.8-V CMOS coupling current-mode injection-locked frequency divider (CCMILFD) with 19.5% locking range and a current-injection current-mode logic (CICML) frequency divider have been designed and fabricated using 0.13-mum 1p8m CMOS technology. In the proposed CCMILFD, the current-mode technique to minimize the loss of input signals and the coupling circuit to enlarge the phase response have been designed to increase the locking range. The locking range of the fabricated CCMILFD is 4.1 GHz with a power consumption of 1.51 mW from a power supply of 0.8 V. In the proposed CICML frequency divider, the current-injection interface is applied to the current inputs to make the circuit operated at a higher frequency with low power consumption under a low voltage supply. The operation frequency of the fabricated CICML frequency divider can divide the frequency range from CCMILFD and consume 1.89 mW from a 0.8-V voltage supply. The chip core areas of the CCMILFD and CICML frequency divider without pads are 0.23 and 0.015 mm2, respectively. The proposed circuits can be operated in a low supply voltage with the advantages of a wider locking range, a higher operation frequency, and lower power consumption.
A Promising Listeria-Vectored Vaccine Induces Th1-Type Immune Responses and Confers Protection Against Tuberculosis

Deaths associated with tuberculosis (TB) is rising and accounted for 1.4 million deaths in 2015 many of which were due to drug-resistant bacteria. Vaccines represent an important medical intervention, but the current Bacilli Calmette-Guerin (BCG) vaccine is not ideal for the protection of teenagers and adults. Therefore, a safe and effective vaccine is urgently needed. In this study, we designed a novel vaccine using an attenuated Listeria monocytogenes strain carrying fusion antigen FbpB-ESAT-6 (rLM) and characterized its safety and protective efficacy against Mycobacterium tuberculosis (M.tb) infection in mice. Compared to the wild type strain yzuLM4 and parental strain LMΔactA/plcB (LM1-2), the virulence of rLM was significantly reduced as judged by its infectious kinetics and LD50 dose. Further characterization of intravenous immunization showed that prime-boost vaccination significantly increased the levels of Th1 cytokines (IFN-γ, IL-17, and IL-6), and enhanced cytotoxic T lymphocyte (CTL) CTLs activity, suggesting that rLM could elicit potent Th1/Th17 responses. More importantly, rLM significantly conferred the protection against M.tb H37Rv challenge. Collectively, our findings indicated that rLM is a novel and useful tool to prevent M.tb infection, and can be potentially be used to boost BCG-primed immunity.
Detection of host DNA sequences including the H-2 locus of the major histocompatibility complex in schistosomes

SUMMARY The mouse type 2 Alu (B2) sequence was detected in both DNAs of Schistosoma mansoni and S. japonicum except for the cercarial stage by the polymerase chain reaction (PCR). Using several kinds of mouse STMS (sequence tagged microsatellite site) primer sets, PCR products related to the host were found in the DNAs of S. mansoni as well as of S. japonicum. Products could be detected only in the DNA of S. japonicum using certain STMS primer sets. The fact that no products could be amplified from the DNAs of both parasites when other kinds of STMS primer sets were used suggests unequal incorporation of the host DNA into the schistosomes. Furthermore, the sequence of the N-terminal domain of H-2, the mouse major histocompatibility complex (MHC), was detected in the DNAs from S. mansoni miracidium, male adult and S. japonicum adults, whereas the sequence of the C2 domain of H-2 was found only in the DNAs of S. japonicum adults. This evidence that host DNA sequences, including the class I MHC, exist heterogeneously in the DNAs of schistosomes might provide an important insight for further understanding of host-parasite immune interactions.
The Pathobiology and Treatment of Hodgkin Lymphoma. Where do We go from Gianni Bonadonna's Lesson?

This article reviews the evolution of the diagnosis and treatment of Hodgkin lymphoma (HL) since its discovery in 1832. The morphological, phenotypic and molecular characteristics of both nodular lymphocyte-predominant HL and classical HL are revised in the light of recent molecular information and possible impact on the identification of risk groups as well as the use of targeted therapies. The seminal contribution of Gianni Bonadonna to developing new treatment strategies for both advanced and early-stage HL is highlighted.
From Entropy to Information: Biased Typewriters and the Origin of Life

The origin of life can be understood mathematically to be the origin of information that can replicate. The likelihood that entropy spontaneously becomes information can be calculated from first principles, and depends exponentially on the amount of information that is necessary for replication. We do not know what the minimum amount of information for self-replication is because it must depend on the local chemistry, but we can study how this likelihood behaves in different known chemistries, and we can study ways in which this likelihood can be enhanced. Here we present evidence from numerical simulations (using the digital life chemistry "Avida") that using a biased probability distribution for the creation of monomers (the "biased typewriter") can exponentially increase the likelihood of spontaneous emergence of information from entropy. We show that this likelihood may depend on the length of the sequence that the information is embedded in, but in a non-trivial manner: there may be an optimum sequence length that maximizes the likelihood. We conclude that the likelihood of spontaneous emergence of self-replication is much more malleable than previously thought, and that the biased probability distributions of monomers that are the norm in biochemistry may significantly enhance these likelihoods
Hep-2–Adherent Escherichia coli Strains Associated with Acute Infantile Diarrhea, São Paulo, Brazil

In this paired case-control study of infants with diarrhea in São Paulo, we examined the association between HEp-2–adherent Escherichia coli strains and diarrhea. We tested isolates from stool specimens of infants with diarrhea and matched controls in an HEp-2 cell adherence assay; we then hybridized isolates with DNA probes and identified enteropathogenic E. coli (EPEC), enteroaggregative E. coli (EAEC), and diffusely adherent E. coli (DAEC). From 100 patient-control pairs, we isolated 78 HEp-2–adherent strains; of these, 61 strains were single pathogens identified in stools of infants with diarrhea. While typical EPEC was significantly associated with diarrhea (p<0.001), EAEC was more frequently associated with diarrhea in clinical cases (20%) compared with healthy controls (3%) (p<0.001). Atypical EPEC, showing a localized adherence-like pattern, was also more common in patients than controls (p>0.1). DAEC was isolated with equal frequency from patients and controls (p>0.1).
Real-time trace gas sensing of ethylene, propanal and acetaldehyde from human skin in vivo

Trace gases emitted by human skin in vivo are monitored non-invasively and in real time using laser-based photoacoustic detection and proton-transfer reaction mass spectrometry. A small quartz cuvette is placed on the skin to create a headspace from which a carrier gas transports the skin emissions to the detection systems. The transparency of quartz to ultraviolet radiation (UVR) allows investigation of UVR-related trace gas emissions. As a demonstration of this measurement system, the effect of supplemental intake of systemic antioxidants on UVR-induced lipid peroxidation is investigated. The production by the skin of three biomarkers of UVR-induced lipid peroxidation (ethylene, acetaldehyde and propanal) is monitored. Although no significant effect of antioxidant intake was observed, the method presented here is a novel and promising technique for investigation of human skin in vivo.
Physical Attractiveness Biases in Ratings of Employment Suitability: Tracking Down the “Beauty is Beastly” Effect

ABSTRACT The “what is beautiful is good” heuristic suggests that physically attractive persons benefit from their attractiveness in a large range of situations, including perceptions of employment suitability. Conversely, the “beauty is beastly” effect suggests that attractiveness can be detrimental to women in certain employment contexts, although these findings have been less consistent than those for the “what is beautiful is good” effect. The current research seeks to uncover situations in which beauty might be detrimental for female applicants. In two studies, we found that attractiveness can be detrimental for women applying for masculine sex-typed jobs for which physical appearance is perceived as unimportant.
Genomic Analyses of Transcription Factor Binding, Histone Acetylation, and Gene Expression Reveal Mechanistically Distinct Classes of Estrogen-Regulated Promoters

ABSTRACT To explore the global mechanisms of estrogen-regulated transcription, we used chromatin immunoprecipitation coupled with DNA microarrays to determine the localization of RNA polymerase II (Pol II), estrogen receptor alpha (ERα), steroid receptor coactivator proteins (SRC), and acetylated histones H3/H4 (AcH) at estrogen-regulated promoters in MCF-7 cells with or without estradiol (E2) treatment. In addition, we correlated factor occupancy with gene expression and the presence of transcription factor binding elements. Using this integrative approach, we defined a set of 58 direct E2 target genes based on E2-regulated Pol II occupancy and classified their promoters based on factor binding, histone modification, and transcriptional output. Many of these direct E2 target genes exhibit interesting modes of regulation and biological activities, some of which may be relevant to the onset and proliferation of breast cancers. Our studies indicate that about one-third of these direct E2 target genes contain promoter-proximal ERα-binding sites, which is considerably more than previous estimates. Some of these genes represent possible novel targets for regulation through the ERα/AP-1 tethering pathway. Our studies have also revealed several previously uncharacterized global features of E2-regulated gene expression, including strong positive correlations between Pol II occupancy and AcH levels, as well as between the E2-dependent recruitment of ERα and SRC at the promoters of E2-stimulated genes. Furthermore, our studies have revealed new mechanistic insights into E2-regulated gene expression, including the absence of SRC binding at E2-repressed genes and the presence of constitutively bound, promoter-proximally paused Pol IIs at some E2-regulated promoters. These mechanistic insights are likely to be relevant for understanding gene regulation by a wide variety of nuclear receptors.
Spiral: A heuristic mapping algorithm for network on chip

: In this paper, a heuristic core mapping algorithm for 2-D mesh topologies called Spiral is proposed. To compare the eﬃcacy of the algorithm, the results of the proposed algorithm are compared with those of the genetic and random mapping algorithms. The experimental results of synthetic traﬃc proﬁles reveal that the Spiral algorithm improves the reduction in the energy consumption as well as the speed of performing application compared to those of the genetic algorithm mapping.
Community Mobilization, Participation, and Blood Pressure Status in a Cardiovascular Health Awareness Program in Ontario

Purpose. To determine the feasibility of a community-wide approach integrated with primary care (Cardiovascular Health Awareness Program [CHAP]) to promote monitoring of blood pressure (BP) and awareness of cardiovascular disease risk. Design. Demonstration project. Setting. Two midsized Ontario communities. Participants. Community-dwelling seniors. Intervention. CHAP sessions were offered in pharmacies and promoted to seniors using advertising and personalized letters from physicians. Trained volunteers measured BP, completed risk profiles, and provided risk-specific education materials. Method. We examined the distribution of risk factors among participants and predictors of multiple visits and elevated BP. Results. Opinion leaders aided recruitment of family physicians (n = 56/63) and pharmacists (n = 18/19). Over 90 volunteers were recruited. Invitations were mailed to 4394 seniors. Over 10 weeks, there were 4165 assessments of 2350 unique participants (approximately 30% of senior residents). 37.5% of attendees had untreated (16%; 360/2247) or uncontrolled (21.5%; 482/2247) high BP. Participants who received a letter (odds ratio [OR] 2.5, 95% confidence interval [CI] 2.1–3.0), had an initial elevated BP (OR 1.2, 95% CI 1.0–1.5), or reported current antihypertensive medication (OR 1.4, 95% CI 1.1–1.6) were more likely to attend multiple sessions (p ≤ .05 for all). Older age (≥ 70 years; OR 1.5, 95% CI 1.3–1.8), BMI ≥ 30 (OR 1.7, 95% CI 1.4–2.2), current antihypertensive medication (OR 1.6, 95% CI 1.3–1.9), and diabetes (OR 2.4, 95% CI 1.9–3.2) predicted elevated BP (p < .001 for all). Conclusion. The program yielded learning about community mobilization and identified a substantial number of seniors with undiagnosed/uncontrolled high BP.
TOR-inhibitor insensitive-1 (TRIN1) regulates cotyledons greening in Arabidopsis

Target of Rapamycin (TOR) is an eukaryotic protein kinase and evolutionally conserved from the last eukaryotic common ancestor (LECA) to humans. The growing evidences have shown that TOR signaling acts as a central controller of cell growth and development. The downstream effectors of TOR have been well-identified in yeast and animals by using the immunosuppression agent rapamycin. However, less is known about TOR in plants. This is largely due to the fact that plants are insensitive to rapamycin. In this study, AZD8055 (AZD), the novel ATP-competitive inhibitor of TOR, was employed to decipher the downstream effectors of TOR in Arabidopsis. One AZD insensitive mutant, TOR-inhibitor insensitive-1 (trin1), was screened from 10,000 EMS-induced mutation seeds. The cotyledons of trin1 can turn green when its seeds were germinated on ½ MS medium supplemented with 2 μM AZD, whereas the cotyledons greening of wild-type (WT) can be completely blocked at this concentration. Through genetic mapping, TRIN1 was mapped onto the long arm of chromosome 2, between markers SGCSNP26 and MI277. Positional cloning revealed that TRIN1 was an allele of ABI4, which encoded an ABA-regulated AP2 domain transcription factor. Plants containing P35S::TRIN1 or P35S::TRIN1-GUS were hypersensitive to AZD treatment and displayed the opposite phenotype observed in trin1. Importantly, GUS signaling was significantly enhanced in P35S::TRIN1-GUS transgenic plants in response to AZD treatment, indicating that suppression of TOR resulted in the accumulation of TRIN1. These observations revealed that TOR controlled seed-to-seedling transition by negatively regulating the stability of TRIN1 in Arabidopsis. For the first time, TRIN1, the downstream effector of TOR signaling, was identified through a chemical genetics approach.
FTO Genotype, Physical Activity, and Coronary Heart Disease Risk in Swedish Men and Women

Background—Variants in the fat mass– and obesity-associated gene (FTO) predisposing to obesity and diabetes mellitus have also been associated with cardiovascular disease. Physical activity has been suggested to attenuate the FTO effect on obesity, but it is unknown whether this is also true for cardiovascular disease. Therefore, we explored whether physical activity modifies the FTO association with coronary heart disease (CHD). Methods and Results—FTO rs9939609 (T>A) polymorphism was genotyped in 2 Swedish population–based case–control studies with 1743 CHD cases and 4402 population controls (25–74 years of age; 41% women). Leisure time physical activity was assessed by questionnaires, and 3 levels were defined: low, medium, and high. Overall, carriers of the FTO A allele had an increased risk of CHD (odds ratio, 1.20; 95% confidence interval, 1.06–1.37) adjusted for age, sex, study, and body mass index. Although A-allele carriers with low physical activity had the highest CHD risk (odds ratio, 3.30; 95% confidence interval, 2.44–4.46) compared with those with TT genotype and high activity, the effects of FTO genotype and physical activity on CHD risk were approximately additive, indicating the absence of additive interaction. The stratum-specific relative risks of CHD from the A allele in subjects with low, medium, and high physical activity were odds ratio 1.11 (95% confidence interval, 0.77–1.60), 1.22 (1.04–1.44), and 1.38 (1.06–1.80), respectively, but the suggested multiplicative interaction was not significant. Conclusions—FTO rs9939609 A-allele carriers have an increased CHD risk, and the association is not counteracted by increased physical activity.
Memory for Unconsciously Perceived Events: Evidence from Anesthetized Patients

Studies investigating memory for events during anesthesia show a confusing pattern of positive and negative results. To establish whether there are any consistent patterns of findings across studies, we conducted a meta-analysis of the data from 2517 patients in 44 studies. The meta-analysis included two measures of the effects of positive suggestions on postoperative recovery: (a) the duration of postoperative hospitalization and (b) the amount of morphine administered via patient-controlled anesthesia, as well as two measures of memory for specific information presented during anesthesia: (c) direct tests and (d) indirect tests. The meta-analysis indicated that positive suggestions presented during anesthesia have little or no effect on postoperative recovery. On the other hand, the meta-analysis showed that specific information is remembered following surgery, as long as testing is not delayed longer than 36 h. Studies of memory for events during anesthesia provide a useful avenue for exploring unconscious cognition.
Adaptive routing with stale information

We investigate adaptive routing policies for large networks in which agents reroute traffic based on old information. It is a well known and practically relevant problem that old information can lead to undesirable oscillation effects resulting in poor performance. We investigate how adaptive routing policies should be designed such that these effects can be avoided.The network is represented by a general graph with latency functions on the edges. Traffic is managed by a large number of agents each of which is responsible for a negligible amount of traffic. Initially the agents' routing paths are chosen in an arbitrary fashion. From time to time each agent revises her routing strategy by sampling another path and switching with positive probability to this path if it promises smaller latencies. As the information on which the agent bases her decision might be stale, however, this does not necessarily lead to an improvement. The points of time at which agents revise their strategy are generated by a Poisson distribution. Stale information is modelled in form of a bulletin board that is updated periodically and lists the latencies on all edges.We analyze such a distributed routing process in the so-called fluid limit, that is, we use differential equations describing the fractions of traffic on different paths over time. In our model, we can show the following effects. Simple routing policies that always switch to the better alternative lead to oscillation, regardless at which frequency the bulletin board is updated. Oscillation effects can be avoided, however, when using smooth adaption policies that do not always switch to better alternatives but only with a probability depending on the advantage in the latency. In fact, such policies have dynamics that converge to a fixed point corresponding to a Nash equilibrium for the underlying routing game, provided the update periods are not too large.In addition, we also analyze the speed of convergence towards approximate equilibria of two specific variants of smooth adaptive routing policies, eg. , for a replication policy adopted from evolutionary game theory.