Miracle-dz/UniFAR-FTUs huggingface dataset:
Active infective endocarditis: Clinical characteristics and factors related to hospital mortality.

BACKGROUND Little information exists on the clinical characteristics and factors related to hospital mortality in patients with active infective endocarditis referred for surgery. METHODS Between January 1, 2003 and December 31, 2006, 86 patients (56 males, 30 females, mean age 59.2 years) with active infective endocarditis were referred to our Department (2.8% of overall hospitalizations). The relation of several clinical, laboratory and echocardiographic findings at admission with hospital mortality was evaluated. RESULTS A native valve (NVE) was involved in 50/86; the other 30 had a prosthetic valve endocarditis (PVE). Six had pacemaker endocarditis. The aortic valve was involved more frequently than the mitral valve, both in NVE and PVE. The tricuspid valve was involved in four drug addicts; 51% of patients were in NYHA class III-IV. Staphylococci and streptococci were isolated in 69% of patients (39% vs 30%). Blood cultures were negative in 24%. Overall hospital mortality has been 11.6%. Two patients died before surgery, eight in the perioperative period. Hospital mortality was closely related to age, clinical and laboratory evidence of advanced septic condition (temperature > 38°C, leukocytosis and creatinine > 2.0 mg/dL) and hemodynamic impairment. CONCLUSIONS Active infective endocarditis is a significant cause of referral to heart surgery departments and hospital mortality is still > 10%. Clinical and laboratory parameters easily available at admission suggest that severe sepsis and/or hemodynamic impairment may be helpful in predicting the clinical outcome in this group of high risk patients.
Response of pigeonpea (Cajanus cajan L. Millsp.) to application of micronutrients through soil and foliar spray of macronutrients on yield, economics and protein content

A field experiment was conducted during kharif 2012-13 at the Agricultural College Farm, Raichur, to study the response of pigeonpea to soil application of micronutrients and foliar spray of macronutrients on yield, yield components, protein yield and economics. The results revealed that the soil application of ZnSO4 @ 25 kg ha-1 along with foliar spray of 19:19:19 @ 0.4 % recorded significantly higher leaf area per plant (27.23 dm2 plant-1) and higher chlorophyll content (66.43 %). Interaction effect was significant with soil application of ZnSO4 @ 25 kg ha-1 along with foliar spray of 19:19:19 @ 0.4 % which produced significantly higher number of pods per plant (285.89), seed yield per plant (43.14 g) and seed yield per hectare (1390 kg ha-1) followed by soil application of ZnSO4 @ 25 kg ha-1 along with foliar spray of 00:00:50 @ 0.3 % (1297 kg ha-1). Soil application of ZnSO4 @ 25 kg ha-1 along with foliar spray of 19:19:19 @ 0.4 % recorded significantly higher protein content (22.47%), protein yield (288.75 kg ha-1), gross returns (` 55,592 ha-1), net returns (` 36,323 ha-1) and BC ratio (2.89).
Applied Machine Learning Method to Predict Children With ADHD Using Prefrontal Cortex Activity: A Multicenter Study in Japan

Objective: To establish valid, objective biomarkers for ADHD using machine learning. Method: Machine learning was used to predict disorder severity from new brain function data, using a support vector machine (SVM). A multicenter approach was used to collect data for machine learning training, including behavioral and physiological indicators, age, and reverse Stroop task (RST) data from 108 children with ADHD and 108 typically developing (TD) children. Near-infrared spectroscopy (NIRS) was used to quantify change in prefrontal cortex oxygenated hemoglobin during RST. Verification data were from 62 children with ADHD and 37 TD children from six facilities in Japan. Results: The SVM general performance results showed sensitivity of 88.71%, specificity of 83.78%, and an overall discrimination rate of 86.25%. Conclusion: A SVM using an objective index from RST may be useful as an auxiliary biomarker for diagnosis for children with ADHD.
Publication details

Crystals of the title compd. are orthorhombic, space group Pbca; Z = 4. Mols. lie on crystallog. centers of inversion, but have approx. C2h mol. symmetry. The parallel thiophene rings are almost exactly planar; the overall conformation of the mol. is chair-like. The mols. have voids that could, in principle, accommodate small guest mols. , although in the crystal structure access to these voids is blocked by neighboring mols.
Tyrosine Phosphorylation-dependent Suppression of a Voltage-gated K+ Channel in T Lymphocytes upon Fas Stimulation*

Selective cell death plays a critical role in the development of the immune system and in the elimination of target cells expressing foreign antigens. Most of programmed cell death occurs by apoptosis. Apoptotic cell death of lymphocytes can be triggered by ligation of APO-1/Fas (CD95) antigen (Suda, T., and Nagata, S. (1994) J. Exp. Med. 179, 873-879; Nagata, S. , and Golstein, P. (1995) Science 267, 1449-1456). We find that activation of Fas leads to the inhibition of the voltage-dependent n-type K+ channels (Kv1.3) studied by patch clamp technique in Jurkat T lymphocytes. Tyrosine kinases have been shown to be crucial in Fas-induced cell death (Eischen, C. M., Dick, C. J., and Leibson, P. J. (1994) J. Immunol. 153, 1947-1954). The inhibition of the current is correlated with the tyrosine phosphorylation of immunoprecipitated and blotted K+ channel protein. We show, that the Src-like protein-tyrosine kinase inhibitor herbimycin A and the deficiency of the p56lck tyrosine kinase in mutant Jurkat cells abolished the channel inhibition and phosphorylation by anti-Fas antibody, while reconstitution of the p56lck kinase partly restored these effects of Fas receptor triggering. These results suggest a regulation of n-type K+ channels by tyrosine kinases upon Fas receptor triggering, which might be important for apoptosis.
Rapid Turnover of Long Noncoding RNAs and the Evolution of Gene Expression

A large proportion of functional sequence within mammalian genomes falls outside protein-coding exons and can be transcribed into long RNAs. However, the roles in mammalian biology of long noncoding RNA (lncRNA) are not well understood. Few lncRNAs have experimentally determined roles, with some of these being lineage-specific. Determining the extent by which transcription of lncRNA loci is retained or lost across multiple evolutionary lineages is essential if we are to understand their contribution to mammalian biology and to lineage-specific traits. Here, we experimentally investigated the conservation of lncRNA expression among closely related rodent species, allowing the evolution of DNA sequence to be uncoupled from evolution of transcript expression. We generated total RNA (RNAseq) and H3K4me3-bound (ChIPseq) DNA data, and combined both to construct catalogues of transcripts expressed in the adult liver of Mus musculus domesticus (C57BL/6J), Mus musculus castaneus, and Rattus norvegicus. We estimated the rate of transcriptional turnover of lncRNAs and investigated the effects of their lineage-specific birth or death. LncRNA transcription showed considerably greater gain and loss during rodent evolution, compared with protein-coding genes. Nucleotide substitution rates were found to mirror the in vivo transcriptional conservation of intergenic lncRNAs between rodents: only the sequences of noncoding loci with conserved transcription were constrained. Finally, we found that lineage-specific intergenic lncRNAs appear to be associated with modestly elevated expression of genomically neighbouring protein-coding genes. Our findings show that nearly half of intergenic lncRNA loci have been gained or lost since the last common ancestor of mouse and rat, and they predict that such rapid transcriptional turnover contributes to the evolution of tissue- and lineage-specific gene expression.
Dopamine modulates synaptic plasticity in dendrites of rat and human dentate granule cells

The mechanisms underlying memory formation in the hippocampal network remain a major unanswered aspect of neuroscience. Although high-frequency activity appears essential for plasticity, salience for memory formation is also provided by activity in ventral tegmental area (VTA) dopamine projections. Here, we report that activation of dopamine D1 receptors in dentate granule cells (DGCs) can preferentially increase dendritic excitability to both high-frequency afferent activity and high-frequency trains of backpropagating action potentials. Using whole-cell patch clamp recordings, calcium imaging, and neuropeptide Y to inhibit postsynaptic calcium influx, we found that activation of dendritic voltage-dependent calcium channels (VDCCs) is essential for dopamine-induced long-term potentiation (LTP), both in rat and human dentate gyrus (DG). Moreover, we demonstrate previously unreported spike-timing–dependent plasticity in the human hippocampus. These results suggest that when dopamine is released in the dentate gyrus with concurrent high-frequency activity there is an increased probability that synapses will be strengthened and reward-associated spatial memories will be formed.
Avian Influenza Circulation in the Camargue (South of France) During the 2006–07 Season

Abstract Situated at the crossroads of numerous migratory routes of Palaearctic birds, the Camargue is considered a high-risk area for the introduction and transmission of numerous avian-borne pathogens. We investigated the epidemiologic cycles of avian influenza viruses (AIVs) in the local bird community by performing regular sampling on a large variety of bird species during 11 consecutive months in 2006–07. To detect the presence of AIV, SYBR green reverse transcriptase–PCR targeting the M gene was performed on 2901 samples from 66 bird species. A clear seasonal pattern of AIV circulation in ducks was observed during autumn and winter, with higher prevalence rates in early fall. Our results also support an absence of circulation of AIV in passerine birds during spring and the wintering periods. Finally, even if the prevalence of infection was very low, AIVs were found in gulls in breeding colonies, indicating a possible specific circulation in spring in these birds.
Yttrium-90 radioembolization of unresectable hepatocellular carcinoma – a single center experience

Purpose To determine the value of radioembolization (RE) for treatment of unresectable hepatocellular carcinoma (HCC). Patients and methods Records of patients undergoing RE for unresectable HCC were retrospectively reviewed. Biochemical and clinical toxicities, imaging response (according to modified Response Evaluation Criteria In Solid Tumors), time-to-progression (TTP) and overall survival (OS) were analyzed. Data were stratified according to clinical and procedural parameters. Univariate and multivariate analyses were performed. Results One hundred and fifteen patients (89 male, mean age 69.3 years) underwent 158 REs (119 resin-, 39 glass-based) (Barcelona Clinic Liver Cancer [BCLC]-A: 6.1%, B: 33.9%, C: 60.0%). Median clinical follow-up was 5.9 (0.9–83.5) months. No grade 4 or 5 clinical toxicities were noted. Objective response rate was 35.6%; disease control rate was 76.7%. Median TTP of the treated part of the liver was 4 (0.9–45.4) months. 108/115 patients died during follow-up (median OS 8.4 [0.3–82.8] months after first RE [BCLC-A: 52.8 months, BCLC-B: 12.4 months, BCLC-C: 6.1 months]). On multivariate analysis, baseline Eastern Co-operative Oncology Group status <1, ascites prior to RE and best imaging response were predictors of longer OS. In BCLC-C patients, tumor burden, ascites prior to RE, baseline gamma-glutamyltransferase and Child–Pugh score were predictive of OS. Conclusions RE is safe and effective in carefully selected patients suffering from HCC with a low complication rate. Low baseline Eastern Co-operative Oncology Group status and absence of ascites prior to RE are positive prognostic factors.
Increased Sheep Lung Vascular Permeability Caused by Histamine

To see whether histamine increases lung vascular permeability to protein, we compared the effects of steady-state histamine infusions on lung vascular pressures, lung lymph flow, and lung lymph protein content with the effects of mechanically elevated lung vascular pressures on these variables in the same unanesthetized sheep. We surgically implanted catheters in the pulmonary artery, the left atrium, the superior vena cava, and a main lung lymphatic. After the sheep had recovered from surgery, we carried out steady-state experiments without anesthesia. Histamine induced a dose-related, quickly reversible increase in lung lymph flow without affecting pulmonary artery pressure, and it caused left atrial pressure to fall. During 4-hour intravenous 4-μg/kg min−' histamine infusions, lymph flow and lymph protein clearance (lymph flow × lymph-plasma protein concentration ratio) increased more than they did with mechanically elevated pressure even though vascular pressures fell. Lymph-plasma protein ratios decreased linearly with increasing lymph flow during increased pressure experiments, but during histamine infusions the ratios did not decrease even though lymph flow increased 2-6-fold. Lymph clearance and permeability-surface area products (PS) for eight protein fractions with molecular radii ranging from 36 to 100 A decreased with increasing molecular size in base-line, increased pressure, and histamine studies. PS values for all eight fractions were significantly higher than base line in histamine experiments but not in increased pressure experiments. Four-hour intravenous histamine infusions caused moderate increases in lung water content. Left atrial infusions had less effect on lymph flow than did intravenous infusions. We conclude that histamine causes pulmonary vascular permeability to protein to increase but that the effects on exchanging vessel porosity are more modest than those suggested for systemic microvessels. Histamine should be considered a possible mediator of increased lung vascular permeability.
On the Generalization Ability of Online Strongly Convex Programming Algorithms

This paper examines the generalization properties of online convex programming algorithms when the loss function is Lipschitz and strongly convex. Our main result is a sharp bound, that holds with high probability, on the excess risk of the output of an online algorithm in terms of the average regret. This allows one to use recent algorithms with logarithmic cumulative regret guarantees to achieve fast convergence rates for the excess risk with high probability. As a corollary, we characterize the convergence rate of PEGASOS (with high probability), a recently proposed method for solving the SVM optimization problem.
Graphical multiscale Web histories: a study of padprints

We have implemented a browser companion called PadPrints that dynamically builds a graphical history-map of visited web pages. PadPrints relies on Pad++, a zooming user interface (ZUI) development substrate, to display the history-map using minimal screen space. PadPrints functions in conjunction with a traditional web browser but without requiring any browser modifications. We performed two usability studies of PadPrints. The first addressed general navigation effectiveness. The second focused on history-relat ed aspects of navigation. In tasks requiring returns to prior pages, users of PadPrints completed tasks in 61.2% of the time required by users of the same browser without PadPrints. We also observed significant decreases in the number of pages accessed when using PadPrints. Users found browsing with PadPrints more satisfying than using Netscape alone.
Cement-Based, Materials-Enhanced Durability from Opuntia Ficus Indica Mucilage Additions

Physical characterization tests were performed on cement-based mortar containing different addition levels (0, 1.5, 4, 8, 42, and 95%, by water replacement concentration) of opuntia ficus indica (OFI) mucilage. Cement mortar cubes prepared with and without mucilage were tested 2145 days after being fabricated. These preliminary findings suggest that the addition of OFI mucilage at water replacement concentrations between 4 and 8% (by water mass replacement) may be suitable for durability-enhancing applications in cement-based mortar.
Depressive Symptoms and Self-Concept in Young People with Spina Bifida 1

Examined self-reported depressive symptoms in 72 young people with spina bifida, ages 9 to 18:11, and matched able-bodied comparison subjects, using the Dimensions of Depression Profile for Children and Adolescents (Harter & Nowakowski, 1987). Independent variables included gender, self-perceptions (including physical appearance), and perceived social support. Young people with spina bifida were at greater risk of depressive mood, low self-worth, and suicidal ideation. Girls, independent of disability, were at greater risk of depressive mood, low self-worth, and self-blame. Multiple regression analyses suggest that global self-worth serves as a mediating variable for the effect of physical appearance self-concept on depressed mood (particularly in young people with spina
Probabilistic group recommendation via information matching

Increasingly, web recommender systems face scenarios where they need to serve suggestions to groups of users; for example, when families share e-commerce or movie rental web accounts. Research to date in this domain has proposed two approaches: computing recommendations for the group by merging any members' ratings into a single profile, or computing ranked recommendations for each individual that are then merged via a range of heuristics. In doing so, none of the past approaches reason on the preferences that arise in individuals when they are members of a group. In this work, we present a probabilistic framework, based on the notion of information matching, for group recommendation. This model defines group relevance as a combination of the item's relevance to each user as an individual and as a member of the group; it can then seamlessly incorporate any group recommendation strategy in order to rank items for a set of individuals. We evaluate the model's efficacy at generating recommendations for both single individuals and groups using the MovieLens and MoviePilot data sets. In both cases, we compare our results with baselines and state-of-the-art collaborative filtering algorithms, and show that the model outperforms all others over a variety of ranking metrics.
A 60-GHz-Band Analog Optical System-on-Package Transmitter for Fiber-Radio Communications

We developed an analog optical system-on-package (SoP) transmitter for a 60-GHz-band radio-over-fiber (RoF) link. The SoP transmitter consisted of an electroabsorption modulator, radio frequency amplifiers, and a bandpass filter. The 60-GHz RoF wireless link was prepared to measure the performance of the SoP transmitter. The transmission characteristics of 64-quadrature amplitude modulation (64-QAM) data of the 60-GHz RoF wireless link, including the SoP transmitter, were investigated by measuring the error vector magnitude (EVM) and signal-to-noise ratio (SNR) with a baseband frequency. The EVM of the 60-GHz RoF wireless link was between 2.25% and 2.80%, and the SNR was between 27.36 and 29.31 dB from 140 and 770 MHz, at input baseband power of -9 dBm. The noise figure had the minimum of 8.44 dB at 500 MHz. We successfully transmitted digital community antenna television (CATV) system signals through the 60-GHz RoF wireless link, including the SoP transmitter. Digital CATV signals of 86 channels could be transmitted through the 60-GHz RoF wireless link, and the total throughput was found to be 2.61 Gb/s.
WAIRS: improving classification accuracy by weighting attributes in the AIRS classifier

AIRS (Artificial Immune Recognition System) has shown itself to be a competitive classifier. It has also proved to be the most popular immune inspired classifier. However, rather than AIRS being a classifier in its own right as previously described, we see AIRS more as a pre-processor to a KNN classifier. It is our view that by not explicitly classing it as such development of this algorithm has been rather held back. Seeing it as a pre-processor allows inspiration to be taken from the machine learning literature where such pre-processors are not uncommon. With this in mind, this paper takes a core feature of many such pre-processors, that of attribute weighting, and applies it to AIRS. The resultant algorithm called WAIRS (Weighted AIRS) uses a weighted distance function during all affinity evaluations. WAIRS is tested on 9 benchmark datasets and is found to outperform AIRS in the majority of cases.
Two hypotheses on the feedback regulation of pancreatic enzyme secretion

We review the mechanisms underlying the feedback regulation of pancreatic enzyme secretion in response to a meal. Pancreatic enzyme secretion in the rat and pig is known to be regulated by a negative feedback mechanism mediated by intestinal trypsin and chymo‐trypsin. Such a mechanism has recently been noted in humans. The presence of these enzymes in the small intestine suppresses pancreatic enzyme secretion, whereas their removal increases it. Two novel peptides have been proposed to account for the stimulation of pancreatic enzyme secretion in response to feeding trypsin inhibitor. One was assumed to be present in rat pancreatic juice and the other to be spontaneously secreted from the rat small intestine. In either case, trypsin and trypsin inhibitors do not directly interact with the luminal surface of the small intestine, but their actions are mediated by a trypsin‐sensitive, cholecystokinin‐releasing peptide. This is a novel explanation of the well‐recognized stimulation of pancreatic enzyme secretion in response to dietary protein intake. — Fushiki, T. ; Iwai, K. Two hypotheses on the feedback regulation of pancreatic enzyme secretion. FASEB J. 3: 121‐126; 1989.
Simplified Soft-Output Detection of CPM Signals Over Coherent and Phase Noise Channels

We consider continuous phase modulations (CPMs) in iteratively decoded serially concatenated schemes. Although the overall receiver complexity mainly depends on that of the CPM detector, almost all papers in the literature consider the optimal maximum a posteriori (MAP) symbol detection algorithm and only a few attempts have been made to design low-complexity suboptimal schemes. This problem is faced in this paper by first considering the case of an ideal coherent detection, then extending it to the more interesting case of a transmission over a typical satellite channel affected by phase noise. In both cases, we adopt a simplified representation of an M-ary CPM signal based on the principal pulses of its Laurent decomposition. Since it is not possible to derive the exact detection rule by means of a probabilistic reasoning, the framework of factor graphs (FGs) and the sum-product algorithm (SPA) is used. In the case of channels affected by phase noise, continuous random variables representing the phase samples are explicitly introduced in the FG. By pursuing the principal approach to manage continuous random variables in a FG, i.e., the canonical distribution approach, two algorithms are derived which do not require the presence of known (pilot) symbols, thanks to the intrinsic differential encoder embedded in the CPM modulator.