Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of ozone on the reproductive biology of Brassica campestris L. and Plantago major L.

Although sexual reproductive development is a critical phase in the life cycle of plants, the effects of air pollutants on the processes involved have not been investigated extensively. This thesis describes experiments undertaken to determine the direct effects of short-term exposures to ozone on the reproductive biology of species with contrasting reproductive growth habits, Brassica campestris L. , an indeterminate species, and Plantago major L. , a more determinate species. Two purpose-designed exposure chambers were constructed, each of which permitted the reproductive structures of up to twelve plants to be isolated from the vegetative parts and exposed simultaneously to ozone-enriched or charcoal-filtered air. The design of these chambers also permitted whole plant exposures. The occurrence of significant decreases in stomatal conductance and the net rate of photosynthesis following exposure to 70 ppb ozone established that the vegetative structures of both B. campestris and P. major were sensitive to ozone. Visible leaf injury also developed in B. campestris, the extent of which varied with the stomatal conductance of plants prior to fumigation and therefore ozone uptake. The growth of B. campestris and P. major was also reduced following 10 and 14 days of exposure respectively to 70 ppb ozone for 7 h d-1. The effects of ozone on growth differed between the four populations of P. major examined in this study. While a single 6 h exposure of the terminal inflorescence of B. campestris to 100 ppb ozone had no significant effect on reproductive development, repeated exposures over four consecutive days increased the abortion of seeds in apical pods and the precocious germination of seeds in older pods. However, the impact on final seed yield was dependent upon the timing of exposure; thus seed yield was significantly reduced following exposure during the early flowering phase, but was unaffected following exposure during the later stages of reproductive development. The compensation for seed losses in more mature plants resulted from their ability to retain naturally aborting seeds in older pods. Nonetheless, single and multiple exposures to ozone both reduced the rate of germination of harvested seeds and multiple exposures affected seed colour. In P. major, exposure of the fIrst spike to 120 ppb ozone for 7 h d1 during flowering primarily affected seed number per capsule. Both significant increases and decreases in seed number were observed in the four popUlations examined, and seed number was also affected in spikes which had not been exposed to ozone, indicating the existence of possible compensation mechanisms. Pollen from both species was also shown to be sensitive to a 6 h in vivo exposure to ozone. The complex responses of B. campestris and P. major following direct exposure of the reproductive structures to ozone suggest that factors other than the type of reproductive growth habit are important in determining the extent of ozone damage and the ability of plants to compensate for reproductive site losses.
Hepatitis C Viral Evolution in Genotype 1 Treatment-Naïve and Treatment-Experienced Patients Receiving Telaprevir-Based Therapy in Clinical Trials

Background In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased sustained virologic response (SVR) rates compared with PR alone. However, genotypic changes could be observed in TVR-treated patients who did not achieve an SVR. Methods Population sequence analysis of the NS3•4A region was performed in patients who did not achieve SVR with TVR-based treatment. Results Resistant variants were observed after treatment with a telaprevir-based regimen in 12% of treatment-naïve patients (ADVANCE; T12PR arm), 6% of prior relapsers, 24% of prior partial responders, and 51% of prior null responder patients (REALIZE, T12PR48 arms). NS3 protease variants V36M, R155K, and V36M+R155K emerged frequently in patients with genotype 1a and V36A, T54A, and A156S/T in patients with genotype 1b. Lower-level resistance to telaprevir was conferred by V36A/M, T54A/S, R155K/T, and A156S variants; and higher-level resistance to telaprevir was conferred by A156T and V36M+R155K variants. Virologic failure during telaprevir treatment was more common in patients with genotype 1a and in prior PR nonresponder patients and was associated with higher-level telaprevir-resistant variants. Relapse was usually associated with wild-type or lower-level resistant variants. After treatment, viral populations were wild-type with a median time of 10 months for genotype 1a and 3 weeks for genotype 1b patients. Conclusions A consistent, subtype-dependent resistance profile was observed in patients who did not achieve an SVR with telaprevir-based treatment. The primary role of TVR is to inhibit wild-type virus and variants with lower-levels of resistance to telaprevir. The complementary role of PR is to clear any remaining telaprevir-resistant variants, especially higher-level telaprevir-resistant variants. Resistant variants are detectable in most patients who fail to achieve SVR, but their levels decline over time after treatment.
Early Changes in Rabbit Cerebral Artery Reactivity After Subarachnoid Hemorrhage

Background and Purpose Subarachnoid hemorrhage frequently leads to long-term cerebral artery narrowing called vasospasm. Very early changes in cerebral arteries have not been studied extensively and may be critical for the later pathological developments. We therefore determined what changes in the reactivity of cerebral arteries could be observed after 10 minutes' or 24 hours' contact with subarachnoid blood. Methods Ten minutes or 24 hours after the injection of blood or physiological solution (sham hemorrhage) into the cisterna magna of anesthetized rabbits or no injection (control rabbits), segments of the middle cerebral, basilar, and vertebral arteries were removed for conventional in vitro tension measurements. Concentration–response curves to four endogenous constrictors likely to be released after hemorrhage were obtained, and the maximum relaxation to acetylcholine was determined. Results There were no significant differences between the sham hemorrhage and control groups. Compared with control rabbits, treated animals showed increased reactivity to uridine triphosphate in the basilar and vertebral arteries at 10 minutes but not at 24 hours, whereas reactivity was increased in the middle cerebral artery only at 24 hours. Reactivity to serotonin was greatly increased in all arteries at both latencies (up to 2.7 times). Reactivity to noradrenaline was unchanged in the basilar and vertebral arteries at 10 minutes; reactivity in both the basilar and middle cerebral arteries was increased at 24 hours, which is compatible with denervation supersensitivity. There were only minor changes in the reactivity to histamine, and only at 10 minutes. Relaxation to acetylcholine was increased for the middle cerebral artery at 10 minutes but otherwise was not significantly changed. Conclusions Reactivity to uridine triphosphate, serotonin, and noradrenaline greatly increases by 10 minutes to 24 hours after subarachnoid hemorrhage, and this increase is not owing to the mechanical effects of intracranial hypertension, nor is it related to impaired endothelium-dependent relaxation. It is suggested that these and other spasmogens cause excessive muscular calcium loading with a very rapid onset after subarachnoid hemorrhage.
The Relationship between the Mechanism of Zinc Oxide Crystallization and Its Antimicrobial Properties for the Surface Modification of Surgical Meshes

Surgical meshes were modified with zinc oxide (ZnO) using a chemical bath deposition method (CBD) at 50 °C, 70 °C, or 90 °C, in order to biologically activate them. Scanning electron microscopy (SEM), mass changes, and X-ray diffraction measurements revealed that at low temperatures Zn(OH)2 was formed, and that this was converted into ZnO with a temperature increase. The antimicrobial activity without light stimulation of the ZnO modified Mersilene™ meshes was related to the species of microorganism, the incubation time, and the conditions of the experiment. Generally, cocci (S. aureus, S. epidermidis) and yeast (C. albicans) were more sensitive than Gram-negative rods (E. coli). The differences in sensitivity of the studied microorganisms to ZnO were discussed. The most active sample was that obtained at 90 °C. The mechanism of antimicrobial action of ZnO was determined by various techniques, such as zeta potential analysis, electron paramagnetic resonance (EPR) spectroscopy, SEM studies, and measurements of Zn(II) and reactive oxygen species (ROS) concentration. Our results confirmed that the generation of free radicals was crucial, which occurs on the surface of crystalline ZnO.
Deep earthquakes in the southwest Pacific: A tectonic interpretation

This paper examines the spatial distribution of deep earthquakes in the Tonga-Fiji-New Hebrides region of the southwest Pacific. Our interpretation emphasizes the complex Cenozoic tectonics of the Pacific/Indo-Australian plate boundary as a primary control on the distribution and deformation of subducted lithosphere. Most deep earthquakes in the interarc region are associated with the contorted Pacific plate lithosphere subducted at the Tonga Trench. However, anomalous groups of deep earthquakes located west of the Tonga zone are unrelated to the present plate configuration. Tectonic reconstructions of the region to 8 m.y. B.P. provide circumstantial evidence that (1) the anomalous events west of the Tonga zone occur in two pieces of detached lithosphere, subducted at the Vitiaz and proto-New Hebrides trenches during the late Miocene, (2) the flattening of the inclined seismic zone in northernmost Tonga is related to the rapid opening of the Lau Basin since 4 m.y. B.P., and (3) the sharp westward curvature of the Tonga seismic zone in this area coincides with a preexisting bend in the late Miocene Vitiaz arc. The sharpness of its present curvature appears to be a secondary effect of shear flow in the lower mantle and compression between detached (Vitiaz) and attached (Tonga) lithosphere. Thus much of the contortion of the subducted lithosphere beneath Tonga-Fiji may be produced by local tectonic interactions, rather than collision of the slab with an impenetrable boundary in the midmantle.
The influence of aprotinin on myocardial function after liver ischemia-reperfusion.

BACKGROUND The beneficial effect of aprotinin, a naturally occurring protease inhibitor, on preservation of organs such as the liver, kidney and lung has been documented. OBJECTIVE To explore the effects of hepatic ischemia and reperfusion on both liver and myocardial function, using a dual isolated perfused organ model with and without aprotinin. METHODS Isolated rat livers were stabilized for 30 minutes with oxygenated modified Krebs-Henseleit solution at 37 degrees C. Livers were then perfused continuously with KH or KH + aprotinin 10(6) KIU/L for an additional 135 min. Livers of two other groups were made globally ischemic for 120 min, then perfused for 15 min with KH or with KH + aprotinin. Isolated hearts (Langendorff preparation) were stabilized for 30 min and then reperfused with KH or KH + aprotinin exiting the liver for 15 min. The liver's circuit was disconnected, and hearts were re-circulated with the accumulated liver + heart effluent for an additional 50 min. RESULTS In the ischemia and ischemia + aprotinin groups, portal vein pressure (1 and 15 min reperfusion) was 331 +/- 99% and 339 +/- 61% vs. 308 +/- 81% and 193 +/- 35% of baseline, respectively (P < 0.03 vs. ischemia). There were no other differences in the enzyme leakage between aprotinin-treated or untreated ischemic livers. Left ventricular pressure was stable in the controls. However, LV pressure in groups perfused with ischemic liver effluent declined within 65 min reperfusion, whether aprotinin treated or not (84 +/- 8% and 73 +/- 5% of baseline, respectively, P < 0.004 only for ischemia vs. control). CONCLUSION When aprotinin was used, LV pressure was inclined to be higher while liver portal vein pressure was lower, thus providing protection against liver and heart reperfusion injury.
Caries incidence and increments in community-living older adults with and without dementia.

OBJECTIVES The Oral Health of Older Adults with Dementia was instigated in the late 1990s to quantify and compare coronal and root caries incidence and increments in community-living older Australians with and without dementia. METHODS A longitudinal design was used to conduct dental inspections at baseline and one-year, for two groups of randomly selected community-living older adults--one group of 116 people with dementia and a comparison group of 116 people without dementia. RESULTS At one-year there were 103 dementia and 113 (112 dentate) non-dementia participants. Coronal and root surface caries incidence was higher for dementia participants (p < 0.05). Dementia participants had higher coronal and root caries adjusted caries increments (ADJCI) (p < 0.01). Both coronal and root ADJCI were evident in half of dementia participants, compared with one-quarter of non-dementia participants. Dementia participants with higher coronal ADJCI were those who had visited the dentist since baseline, who were taking neuroleptics with high anticholinergic adverse effects, and whose carer had high carer burden score (p < 0.01). Dementia participants with higher root ADJCI were those needing assistance with oral hygiene care and whose carers had difficulties with oral hygiene care (p < 0.05). Baseline characteristics predictive in linear regression for: (1) coronal caries increments among all participants were--dementia participants, those with cognitive testing scores indicative of moderate-severe dementia, those with private health insurance; (2) root caries increments among all participants were--dementia participants, and those who had > or = 1 decayed/filled root surface at baseline. Among dementia participants, being male was the baseline characteristic predictive in logistic regression for coronal caries increments, and having > or = 1 decayed coronal surface was the baseline characteristic predictive for root caries increments. CONCLUSIONS Coronal and root caries incidence and increments were significantly higher in the community-living older adults with dementia over the one-year follow-up period. Dementia participants had high levels of coronal and root caries increments; characteristics related to high caries increments included sex (males), dementia severity (moderate-severe), high carer burden, oral hygiene care difficulties, use of neuroleptic medication (with high anticholinergic adverse effects) and previous experience of caries.
Pore-scale to Core-scale Aspects of Capillary Desaturation Curves Using CT-scan Imaging

Surfactant flooding is one of the effective technologies to enhance oil recovery of water flooded petroleum reservoirs. Several previous studies have demonstrated that the release of oil from a rock submitted to waterflood depends on the competition between displacing forces (viscous and buoyancy) and capillary forces. This competition is expressed by two dimensionless numbers, the Capillary number, defined as the ratio of viscous to capillary forces and the Bond number, defined as the ratio of gravity to capillary forces. At the core scale the evolution of the oil residual saturation as function of the capillary number is better known as the Capillary Desaturation Curve (CDC), which constitutes an important input parameter in EOR processes reservoir simulation. In this work we present a new experimental workflow to investigate the effect of rock structure on the CDC. This workflow combines core flood experiments and CT-scan imaging to accurately measure the mean residual oil saturation at different capillary number values as well as the local saturation distribution along the core plug. The CDC was measured on a set of water-wet sandstone with different permeability and degree of heterogeneity. The capillary number was varied by injecting a surfactant solution at different flow rates. Using this methodology, we first study the effect of core flood orientation (Horizontal injection and vertical downflow injection). The resulting local saturation curves show that in a horizontal configuration the oil migrates upwards in the sample inducing an oriented front strongly deviating from the piston like displacement, and very different from the one observed in the vertically placed sample. This behaviour is manly attributed to buoyancy forces that are no more negligible compared to capillary forces when surfactant is injected. This experiment shows that when measuring a CDC the capillary number needs to be corrected to take into account the buoyancy forces. In a second step we have investigated the effect of local heterogeneity of core plugs on the CDC with Clashach and Fontainebleau sandstones. Two samples of Clashash sandstone with equivalent mean properties were studied (mean permeability of 380 and 426 md and mean porosity of 13.4 % and 14.1% respectively). The resulting CDC curve exhibits almost two decades difference in the critical capillary number. This discrepancy is explained in terms of the local variation of the porosity that induces important differences in the local saturation profile.
Biologics: Targets and Therapy Dovepress Safety of Biologics in Rheumatoid Arthritis: Data from Randomized Controlled Trials and Registries

Over the past decade, the use of biologics has significantly changed the management of rheumatoid arthritis (RA). Biologics selectively target components of the immune system, resulting in better disease control. However, the growing use of biologics in RA has increased safety concerns among rheumatologists. Randomized controlled trials (RCTs) and registries are the most reliable sources of clinical safety data. Although safety data from RCTs provide certain insights into the clinical safety profile of an agent, strict constraints in study design (eg, exclusion criteria and restrictive treatment protocols) often do not accurately reflect possible safety issues in the use of the agent, either in the clinical setting or over long-term treatment. Registries, on the other hand, are not restrictive regarding patient enrollment, making them more reliable in evaluating long-term safety. A number of registries have been established globally: in Europe, the United States, and Asia. However, the availability of registry data from Eastern Europe is lacking. The notable exceptions so far are registries from the Czech Republic (ATTRA, a registry of patients treated with anti-tumor necrosis factor-alpha drugs) and Serbia (National registry of patients with rheumatoid arthritis in Serbia [NARRAS]). The current report provides an overview of safety data with biologics in RA from RCTs and registries. Availability of regional safety data from Eastern Europe is of great importance to its clinicians for making evidence-based treatment decisions in RA.
Mental imagery, reasoning, and blindness

Although reasoning seems to be inextricably linked to seeing in the “mind's eye”, the evidence is equivocal. In three experiments, sighted, blindfolded sighted, and congenitally totally blind persons solved deductive inferences based on three sorts of relation: (a) visuo-spatial relations that are easy to envisage either visually or spatially, (b) visual relations that are easy to envisage visually but hard to envisage spatially, and (c) control relations that are hard to envisage both visually and spatially. In absolute terms, congenitally totally blind persons performed less accurately and more slowly than the sighted on all such tasks. In relative terms, however, the visual relations in comparison with control relations impeded the reasoning of sighted and blindfolded participants, whereas congenitally totally blind participants performed the same with the different sorts of relation. We conclude that mental images containing visual details that are irrelevant to an inference can even impede the process of reasoning. Persons who are blind from birth—and who thus do not tend to construct visual mental images—are immune to this visual-impedance effect.
Satellite observation of the Zhejiang Coastal upwelling in the East China Sea during 2007-2009

In this article, EOS MODIS sea surface temperature (SST) data are used to observe the Zhejiang Coastal Upwelling in the East China Sea. MODIS SST data in summer from 2007 to 2009 are selected and processed. Based on the upwelling's temperature features in SST imagery, a temperature threshold approach is established to measure the physical parameters of the upwelling. And then the temporal and spatial characteristics of the upwelling are analyzed. Results show that the upwelling distributes along the Zhejiang Coast running from south to northeast, and covers an average area of 11,000 square kilometers. The mean temperature of the upwelling is about 25~28°C, and its temperature difference from surrounding non-upwelling waters is in the ranges of 2~4°C. The upwelling appears in June and develops to its strongest period in July and August, and then it weakens and vanishes in late September. Three years of observational results reveal that the upwelling has short-time, seasonal and interannual variances. The upwelling is also closely related to the coastal topography.
Semi-supervised image classification based on a multi-feature image query language

The area of Content-Based Image Retrieval (CBIR) deals with a wide range of research disciplines. Being closely related to text retrieval and pattern recognition, the probably most serious issue to be solved is the so-called \semantic gap". Except for very restricted use-cases, machines are not able to recognize the semantic content of digital images as well as humans. This thesis identifies the requirements for a crucial part of CBIR user interfaces, a multimedia-enabled query language. Such a language must be able to capture the user's intentions and translate them into a machine-understandable format. An approach to tackle this translation problem is to express high-level semantics by merging low-level image features. Two related methods are improved for either fast (retrieval) or accurate(categorization) merging. A query language has previously been developed by the author of this thesis. It allows the formation of nested Boolean queries. Each query term may be text- or content-based and the system merges them into a single result set. The language is extensible by arbitrary new feature vector plug-ins and thus use-case independent. This query language should be capable of mapping semantics to features by applying machine learning techniques; this capability is explored. A supervised learning algorithm based on decision trees is used to build category descriptors from a training set. Each resulting \query descriptor" is a feature-based description of a concept which is comprehensible and modifiable. These descriptors could be used as a normal query and return a result set with a high CBIR based precision/recall of the desired category. Additionally, a method for normalizing the similarity profiles of feature vectors has been developed which is essential to perform categorization tasks. To prove the capabilities of such queries, the outcome of a semi-supervised training session with \leave-one-object-out" cross validation is compared to a reference system. Recent work indicates that the discriminative power of the query-based descriptors is similar and is likely to be improved further by implementing more recent feature vectors.