Miracle-dz/UniFAR-FTUs huggingface dataset:
Disentangling Genetic Variation for Resistance and Tolerance to Infectious Diseases in Animals

Hosts can in principle employ two different strategies to defend themselves against parasites: resistance and tolerance. Animals typically exhibit considerable genetic variation for resistance (the ability to limit parasite burden). However, little is known about whether animals can evolve tolerance (the ability to limit the damage caused by a given parasite burden). Using rodent malaria in laboratory mice as a model system and the statistical framework developed by plant-pathogen biologists, we demonstrated genetic variation for tolerance, as measured by the extent to which anemia and weight loss increased with increasing parasite burden. Moreover, resistance and tolerance were negatively genetically correlated. These results mean that animals, like plants, can evolve two conceptually different types of defense, a finding that has important implications for the understanding of the epidemiology and evolution of infectious diseases.
Discovery of a Binary Active Galactic Nucleus in the Ultraluminous Infrared Galaxy NGC 6240 Using Chandra

Ultraluminous infrared galaxies (ULIRGs) are outstanding due to their huge luminosity output in the infrared, which is predominantly powered by superstarbursts and/or hidden active galactic nuclei (AGNs). NGC 6240 is one of the nearest ULIRGs and is considered a key representative of its class. Here we report the first high-resolution imaging spectroscopy of NGC 6240 in X-rays. The observation, performed with the ACIS-S detector aboard the Chandra X-Ray Observatory, led to the discovery of two hard nuclei, coincident with the optical-IR nuclei of NGC 6240. The AGN character of both nuclei is revealed by the detection of absorbed, hard, luminous X-ray emission and two strong neutral Fe Kα lines. In addition, extended X-ray emission components are present, changing their rich structure in dependence of energy. The close correlation of the extended emission with the optical Hα emission of NGC 6240, in combination with the softness of its spectrum, clearly indicates its relation to starburst-driven superwind activity.
Changepoint Detection in Periodic and Autocorrelated Time Series

Abstract Undocumented changepoints (inhomogeneities) are ubiquitous features of climatic time series. Level shifts in time series caused by changepoints confound many inference problems and are very important data features. Tests for undocumented changepoints from models that have independent and identically distributed errors are by now well understood. However, most climate series exhibit serial autocorrelation. Monthly, daily, or hourly series may also have periodic mean structures. This article develops a test for undocumented changepoints for periodic and autocorrelated time series. Classical changepoint tests based on sums of squared errors are modified to take into account series autocorrelations and periodicities. The methods are applied in the analyses of two climate series.
Contribution of Shellfish Consumption to Lower Mercury Health Risk for Residents in Northern Jiaozhou Bay, China

Fish and marine mammal consumption are an important pathway for human exposure to mercury. The low mercury content in shellfish poses a low mercury health risk to people who consume shellfish. The objectives of this study are to detect mercury concentrations in different species of shellfish and to calculate the mercury health risk from shellfish consumption among traditional residents near northern Jiaozhou Bay. A total of 356 shellfish samples, which comprised 7 species from 5 different places in northern Jiaozhou Bay, were collected from April to June in 2012. The average mercury content in the collected shellfish ranged from 0.024 mg·kg−1 to 0.452 mg·kg−1. A total of 44 shellfish samples (12.36%) had mercury levels exceeding the national pollution-free aquatic products limit (0.3 mg·kg−1). Generally, the viscus had the highest mercury content among all parts of the shellfish. A positive correlation between mercury content and total weight/edible part weight was found in most species of the collected shellfish. The results showed that shellfish consumption resulted in the lower risk of mercury exposure to residents based on the calculation of daily intake (DI) and target hazard quotient (THQ).
Video interactions in online video social networks

This article characterizes video-based interactions that emerge from YouTube's video response feature, which allows users to discuss themes and to provide reviews for products or places using much richer media than text. Based on crawled data covering a representative subset of videos and users, we present a characterization from two perspectives: the video response view and the interaction network view. In addition to providing valuable statistical models for various characteristics, our study uncovers typical user behavioral patterns in video-based environments and shows evidence of opportunistic behavior.
NOTES AND CORRESPONDENCE The Effect of a Large Freshwater Perturbation on the Glacial North Atlantic Ocean Using a Coupled General Circulation Model

The commonly held view of the conditions in the North Atlantic at the last glacial maximum, based on the interpretation of proxy records, is of large-scale cooling compared to today, limited deep convection, and extensive sea ice, all associated with a southward displaced and weakened overturning thermohaline circulation (THC) in the North Atlantic. Not all studies support that view; in particular, the “strength of the overturning circulation” is contentious and is a quantity that is difficult to determine even for the present day. Quasi-equilibrium simulations with coupled climate models forced by glacial boundary conditions have produced differing results, as have inferences made from proxy records. Most studies suggest the weaker circulation, some suggest little or no change, and a few suggest a stronger circulation. Here results are presented from a three-dimensional climate model, the Hadley Centre Coupled Model version 3 (HadCM3), of the coupled atmosphere–ocean–sea ice system suggesting, in a qualitative sense, that these diverging views could all have occurred at different times during the last glacial period, with different modes existing at different times. One mode might have been characterized by an active THC associated with moderate temperatures in the North Atlantic and a modest expanse of sea ice. The other mode, perhaps forced by large inputs of meltwater from the continental ice sheets into the northern North Atlantic, might have been characterized by a sluggish THC associated with very cold conditions around the North Atlantic and a large areal cover of sea ice. The authors’ model simulation of such a mode, forced by a large input of freshwater, bears several of the characteristics of the Climate: Long-range Investigation, Mapping, and Prediction (CLIMAP) Project’s reconstruction of glacial sea surface temperature and sea ice extent.
Economic analysis of resource market in cloud computing environment

Cloud computing has been emerged as the flexible, efficient, and economical distributed computing platform to meet the dynamic and random demand from the users. In this paper, we consider cloud computing environment with resource market between private clouds (i.e., buyers) and service providers (i.e., sellers) in public cloud. Economic analysis is proposed for different types of resource markets, i.e., monopoly (single service provider), competitive and cooperative oligopolies (few service providers). We study the optimal strategy for service provider in monopoly market, the Nash equilibria in competitive oligopoly market, and bargaining solution in cooperative oligopoly market. In addition, the decision and condition for service providers to to establish collusion in the oligopoly market are also investigated.
Applied Creativity: The Creative Marketing Breakthrough Model

Despite the increasing importance of personal creativity in today's business environment, few conceptual creativity frameworks have been presented in the marketing education literature. The purpose of this article is to advance the integration of creativity instruction into marketing classrooms by presenting an applied creative marketing framework. The theoretical basis for the creativity framework, referred to as the creative marketing breakthrough model, is discussed along with its pedagogical implications for marketing education. Furthermore, an illustrated instructional example is provided to highlight the impact of the creative marketing breakthrough model constructs on individual creative performance.
Aggregation of Human Eyelid Adipose-derived Stem Cells by Human Body Fluids

Fetal bovine serum (FBS) is the most frequently used serum for the cultivation of mammalian cells. However, since animal-derived materials might not be appropriate due to safety issues, allogeneic human serum (HS) has been used to replace FBS, particularly for the culture of human cells. While there has been a debate about the advantages of HS, its precise effect on human adult stem cells have not been clarified. The present study aimed to investigate the effect of HS on the human eyelid adipose stem cells (HEACs) in vitro. When HEACs were cultivated in a medium containing 10% HS, many cells moved into several spots and aggregated there. The phenomenon was observed as early as 9 days following 10% HS treatment, and 12 days following 5% HS plus 5% FBS treatment. However, the aggregation was never observed when the same cells were cultivated with 10% FBS or bovine serum albumin. To examine whether cell density might affect the aggregation, cells were seeded with different densities on 12-well dish. Until the beginning of aggregation, cells seeded at low densities exhibited the longest culture period of 16 days whereas cells seeded at high densities showed the shortest period of 9 days to form aggregation. The number of cells was 15.1±0.2×104 as the least for the low density group, and 29.3±2.8×104 as the greatest for the high density group. When human cord blood serum or normal bovine serum was examined for the same effect on HEACs, interestingly, cord blood serum induced the aggregation of cells whereas bovine serum treatment has never induced. When cells were cultivated with 10% HS for 9 days, they were obtained and analyzed by RT-PCR. Compared to FBS-cultivated HEACs, HS-cultivated HEACs did not express VIM, and less expressed GATA4, PALLD. On the other hand, HS-cultivated HEACs expressed MAP2 more than FBS-cultivated HEACs. In conclusion, human adult stem cells could move and form aggregates by the treatment with human body fluids.
Melanoma: From Incurable Beast to a Curable Bet. The Success of Immunotherapy

After Coley’s observation in 1891 of tumor regression in a patient who developed a postoperative infection, the field of immunotherapy is finally reborn. Avoiding immune destruction is now considered a hallmark of cancer, and the immunotherapy arena has exploded with the recent advances demonstrating an improvement in survival and a durability of response in patients with different cancer types, which translates into improved overall survival benefit. Here, we provide an overview of the main immune-oncology treatment strategies that, either alone or in combination, are undergoing clinical development. Namely, we will refer to those immunotherapeutic strategies that include adoptive transfer of ex vivo activated T cells, immunomodulatory monoclonal antibodies, and cancer vaccines. Our major focus will be to describe these approaches in melanoma, a cancer type transformed by immunotherapy into a potentially curable disease.
Direct Structural Connections between Voice- and Face-Recognition Areas

Currently, there are two opposing models for how voice and face information is integrated in the human brain to recognize person identity. The conventional model assumes that voice and face information is only combined at a supramodal stage (Bruce and Young, 1986; Burton et al., 1990; Ellis et al., 1997). An alternative model posits that areas encoding voice and face information also interact directly and that this direct interaction is behaviorally relevant for optimizing person recognition (von Kriegstein et al., 2005; von Kriegstein and Giraud, 2006). To disambiguate between the two different models, we tested for evidence of direct structural connections between voice- and face-processing cortical areas by combining functional and diffusion magnetic resonance imaging. We localized, at the individual subject level, three voice-sensitive areas in anterior, middle, and posterior superior temporal sulcus (STS) and face-sensitive areas in the fusiform gyrus [fusiform face area (FFA)]. Using probabilistic tractography, we show evidence that the FFA is structurally connected with voice-sensitive areas in STS. In particular, our results suggest that the FFA is more strongly connected to middle and anterior than to posterior areas of the voice-sensitive STS. This specific structural connectivity pattern indicates that direct links between face- and voice-recognition areas could be used to optimize human person recognition.
The SRI Speech-Based Collaborative Learning Corpus

We introduce the SRI speech-based collaborative learning corpus, a novel collection designed for the investigation and measurement of how students collaborate together in small groups. This is a multi-speaker corpus containing high-quality audio recordings of middle school students working in groups of three to solve mathematical problems. Each student was recorded via a head-mounted noise-cancelling microphone. Each group was also recorded via a stereo microphone placed nearby. A total of 80 sessions were collected with the participation of 134 students. The average duration of a session was 20 minutes. All students spoke English; for some students, English was a second language. Sessions have been annotated with time stamps to indicate which mathematical problem the students were solving and which student was speaking. Sessions have also been hand annotated with common indicators of collaboration for each speaker (e.g., inviting others to contribute, planning) and the overall collaboration quality for each problem. The corpus will be useful to education researchers interested in collaborative learning and to speech researchers interested in children’s speech, speech analytics, and speech diarization. The corpus, both audio and annotation, will be made available to researchers.
Problematic Use of the Mobile Phone: A Literature Review and a Pathways Model

Despite its unambiguous advantages, cellular phone use has been associated with harmful or potentially disturbing behaviors. Problematic use of the mobile phone is considered as an inability to regulate one's use of the mobile phone, which eventually involves negative consequences in daily life (e.g., financial problems). The current article describes what can be considered dysfunctional use of the mobile phone and emphasizes its multifactorial nature. Validated assessment instruments to measure problematic use of the mobile phone are described. The available literature on risk factors for dysfunctional mobile phone use is then reviewed, and a pathways model that integrates the existing literature is proposed. Finally, the assumption is made that dysfunctional use of the mobile phone is part of a spectrum of cyber addictions that encompasses a variety of dysfunctional behaviors and implies involvement in specific online activities (e.g., video games, gambling, social networks, sex-related websites).
Repeated Muscle Injury as a Presumptive Trigger for Chronic Masticatory Muscle Pain

skeletal muscles sustain a significant loss of maximal contractile force after injury, but terminally damaged fibers can eventually be replaced by the growth of new muscle (regeneration), with full restoration of contractile force over time. After a second injury, limb muscles exhibit a smaller reduction in maximal force and reduced inflammation compared with that after the initial injury (i.e., repeated bout effect). In contrast, masticatory muscles exhibit diminished regeneration and persistent fibrosis, after a single injury; following a second injury, plasma extravasation is greater than after a single injury and maximal force is decreased more than after the initial injury. Thus, masticatory muscles do not exhibit a repeated bout effect and are instead increasingly damaged by repeated injury. We propose that the impaired ability of masticatory muscles to regenerate contributes to chronic muscle pain by leading to an accumulation of tissue damage, fibrosis, and a persistent elevation and prolonged membrane translocation of nociceptive channels such as P2X3 as well as enhanced expression of neuropeptides including CGRP within primary afferent neurons. These transformations prime primary afferent neurons for enhanced responsiveness upon subsequent injury thus triggering and/or exacerbating chronic muscle pain.
Speech Perception: A Review

Speech perception deals with how a listener is able to comprehend the underlying meaning of an utterance. Speech perception has long been researched and various attempts to understand and present a complete view of the process have been made. However as easy as it seems to an individual, speech perception involves cognitive science, linguistics, in addition to the engineering aspect of speech. This paper gives a brief review of the work carried out in this field, its issues, models of perception, the various cues to vowel and consonant perception, multimodal perception, and the future
Risk Factors for the Rupture of Middle Cerebral Artery Bifurcation Aneurysms Using CT Angiography

Background and Purpose To investigate the clinical and morphological characteristics associated with risk factors for the rupture of bifurcation-type middle cerebral artery aneurysms (MCAAs). Methods A total of 169 consecutive patients with 177 bifurcation-type MCAAs were reviewed from August 2011 to January 2016. Based on the clinical and morphologic characteristics findings, the risk factors of aneurysm rupture were assessed using statistical methods. Results Age, cerebral atherosclerosis, no hypertension, hypertension grade 2 and coronary artery disease (CAD) were negatively correlated with aneurysm rupture. The mean diameter (MD) of the parent and two daughter arteries was negatively correlated with rupture. Aneurysms with irregularity, depth, width, maximum size, aspect ratio, depth-to-width ratio, bottleneck factor, and size ratio were positively correlated with rupture. The multivariate logistic regression model revealed that irregular shape (odds ratio (OR) 2.697) and aspect ratio (OR 3.723) were significantly and positively correlated with rupture, while cerebral atherosclerosis (OR 0.033), CAD (OR 0.080), and MD (OR 0.201) were negatively correlated with rupture. Receiver operating characteristic analysis revealed that the threshold value of the aspect ratio and MD were 0.96 and 2.43 mm, respectively. Conclusions Cerebral atherosclerosis and CAD are protective factors against rupture. Morphological characteristics such as an aneurysm with an irregular shape, a high aspect ratio (>0.96) and a small MD (<2.43 mm) are likely better predictors of rupture.
The Impact of Mutation Rate on the Computation Time of Evolutionary Dynamic Optimization

Mutation has traditionally been regarded as an important operator in evolutionary algorithms. In particular, there have been many experimental studies which showed the effectiveness of adapting mutation rates for various static optimization problems. Given the perceived effectiveness of adaptive and self-adaptive mutation for static optimization problems, there have been speculations that adaptive and self-adaptive mutation can benefit dynamic optimization problems even more since adaptation and self-adaptation are capable of following a dynamic environment. However, few theoretical results are available in analyzing rigorously evolutionary algorithms for dynamic optimization problems. It is unclear when adaptive and self-adaptive mutation rates are likely to be useful for evolutionary algorithms in solving dynamic optimization problems. This paper provides the first rigorous analysis of adaptive mutation and its impact on the computation times of evolutionary algorithms in solving certain dynamic optimization problems. More specifically, for both individual-based and population-based EAs, we have shown that any time-variable mutation rate scheme will not significantly outperform a fixed mutation rate on some dynamic optimization problem instances. The proofs also offer some insights into conditions under which any time-variable mutation scheme is unlikely to be useful and into the relationships between the problem characteristics and algorithmic features (e.g., different mutation schemes).
Adding Environmental Gas Physics to the Semianalytic Method for Galaxy Formation: Gravitational Heating

Motivated by hydrodynamical simulations, we present results of an attempt to include more detailed gas physics within semianalytic models (SAMs) of galaxy formation, focusing on the role played by environmental effects. The main difference from previous SAMs is that we include “gravitational” heating of the intracluster medium (ICM) by the net surplus of gravitational potential energy released from gas that has been stripped from infalling satellites. Gravitational heating appears to be an efficient heating source able to prevent cooling in environments corresponding to dark matter halos more massive than M* at any given redshift because of the continued growth by mergers. The energy release by gravitational heating can match that by AGN feedback in massive galaxies and can exceed it in the most massive ones. However, there is a fundamental difference in the way the two processes operate. Gravitational heating becomes important at late times, when the peak activity of AGNs is already over, and it is very mass dependent. This mass dependency and time behavior gives the right trend to recover downsizing in the star formation rate of massive galaxies. We present a number of first-order comparisons of our model to well-established observations of galaxy properties, which can be summarized as follows. The cosmic star formation rate is reproduced well. In addition, the star formation episode of our model galaxies is a strong function of mass. Massive galaxies with M* > 1011 M☉ make most of their stars at look-back times of roughly 11 Gyr and show very low amounts of residual star formation at late times due to suppression by environmental effects. Furthermore, the luminosity function and color bimodality of the galaxy population are reproduced well.
A background paper to inform the development of a national professional development framework for teachers and school leaders

This background paper was commissioned by AITSL in April 2011 to inform the development of a national professional development framework for Australian teachers and school leaders. The views, findings, conclusions and recommendations herein are those of the authors ad do not necessarily represent the official positions or policies of AITSL or the educational institutions of the authors. 1 A background paper to inform the development of a national professional development framework for teachers and school leaders
On the Style-Based Feedback Trading of Mutual Fund Managers

Abstract This paper examines the style-based feedback trading behavior of U.S. mutual fund managers. We provide an empirical version of Barberis and Shleifer’s style-switching model. We find style-based feedback trading for 77% of the funds, half of which is positive (negative) feedback trading. There is evidence for “twin style” switching, where capital is channeled between value and growth, and between large- and small-cap. Growth (value) funds apply more positive (negative) feedback trading. Funds that switch more aggressively are younger and have higher expense ratios. Finally, we find that positive (negative) feedback trading yields positive (negative) alpha.