Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation of grain boundary extra free volume with vacancy and solute segregation at grain boundaries: a case study for Al

Abstract Grain boundary extra free volume (GB EFV) can be considered as fundamental microstructural parameter for polycrystalline or nano-crystalline materials. Here, we present a systematic first principles study on a group of representative symmetric tilt grain boundaries of Al with various EFVs subjected to vacancy formation and Mg segregation. All grain boundaries were constructed using the coincident site lattice (CSL) and the structural unit (SU) models. It was found that the SU model is superior to the CSL in describing FCC-Al GBs, the same as we previously revealed for BCC-Fe. The predicted relation between GB misorientation angle and EFV, and the predicted EFV criteria for a stable GB, both agree with available experimental observations. Vacancy formation and Mg segregation show stronger preference to those GBs with high EFV values, due to the resultant high levels of atomic disorder. These findings not only provide a new, atomistic perspective on the significance of EFV, but also suggest a viable means of predicting GB properties based on direct experimental characterisation of GB EFVs.
The long-term spatial-temporal trends and burden of esophageal cancer in one high-risk area: A population-registered study in Feicheng, China

Background Feicheng County is a high-risk area for esophageal cancer in Shandong province, China. It is important to determine the long-term spatio-temporal trends in epidemiological characteristics and the burden of esophageal cancer, especially since the implementation of the national esophageal cancer screening program for early detection and treatment in 2005. Methods The data collected in Feicheng County from 2001 to 2012 was extracted from the whole-population cancer registry system. The incidence, mortality, disability-adjusted life years (DALY) and changing trends in esophageal cancer according to age and sex were calculated and described. Results The incidence rate of esophageal cancer in Feicheng was consistently high, and increased significantly for male, but not for female from 2001 to 2012, according to the joinpoint regression analysis. The highest and lowest yearly crude incidence rates were 160.78 and 95.97 per 100000 for males, and 81.36 and 52.17 per 100000 for females. The highest and lowest crude yearly mortality rates were 122.26 and 94.40 per 100000 for males, and 60.75 and 49.35 per 100000for females. Esophageal squamous cell carcinoma was the main pathology type and the tumor location changed significantly from 2001 to 2012. Overall, the DALY remained roughly stable and was estimated as 11.50 for males and 4.90 for females per 1000 people. The burden was mainly caused by premature death. There is an obvious spatial pattern in the distribution of incidence density and burden. Conclusion Esophageal cancer remains a public health issue in Feicheng County with a high incidence, mortality and disease burden. The incidence and burden have obvious spatial heterogeneity, and further studies should be conducted to identify geographical risk factors for precise local prevention and control measures.
The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells

Interaction of the Eph family of receptor protein tyrosine kinases and their ligands, ephrin family members, induces bi-directional signaling via cell-cell contacts. High expression of B-type ephrin is associated with high invasion potential of tumors, however, the mechanism by which ephrin-B promotes cancer cell invasion is poorly understood. We show that interaction of ephrin-B1 with the Eph receptor B2 (EphB2) significantly enhances processing of the extracellular domain of ephrin-B1, which is regulated by the C-terminus. Matrix metalloproteinase-8 (MMP-8) is the key protease that cleaves ephrin-B1, and the C-terminus of ephrin-B1 regulates activation of the extracellular release of MMP-8 without requirement of de novo protein synthesis. One possible mechanism by which ephrin-B1 regulates the exocytosis of MMP-8 is the activation of Arf1 GTPase, a critical regulator of membrane trafficking. In support of this hypothesis, activation of ephrin-B1 increased GTP-bound Arf1, and the secretion of MMP-8 was reduced by expression of a dominant-negative mutant of Arf1. Expression of ephrin-B1 promoted the invasion of cancer cells in vivo, which required the C-terminus of ephrin-B1. Our results suggest a novel function of the C-terminus of ephrin-B1 in activating MMP-8 secretion, which promotes the invasion of cancer cells.
Suspended Tunnel Junction Bolometers For Terahertz Range

Implementation of high resolution passive THz cameras operated at cryogenic temperatures of a few Kelvin benefits from a large number of pixels. At present, building a cryogenic multiplexed read-out circuit represents a challenging task. Here we propose and demonstrate broadband niobium-based tunnel junction bolometers operating in equilibrium regime at 4 K, and read out with a room temperature amplifier with feedback. The implemented scheme allows independent impedance matching for the THz antenna and for the readout. Electrical feedback in the readout scheme eliminates the need for magnetic fields to suppress the supercurrent of the junction. We present electrical and preliminary optical measurements of the detectors. We also analyze a possible scheme for time-domain multiplexing.
Abnormal P‐Wave Morphology Is a Predictor of Atrial Fibrillation Development and Cardiac Death in MADIT II Patients

Background: Several ECG‐based approaches have been shown to add value when risk‐stratifying patients with congestive heart failure, but little attention has been paid to the prognostic value of abnormal atrial depolarization in this context. The aim of this study was to noninvasively analyze the atrial depolarization phase to identify markers associated with increased risk of mortality, deterioration of heart failure, and development of atrial fibrillation (AF) in a high‐risk population with advanced congestive heart failure and a history of acute myocardial infarction.
Numerical Analysis of Keddara Dam under Seismic Motion

The Boumerdes earthquake of May 21, 2003 in Algeria, which widely felt within a radius of ~ 400 km, caused damage in five provinces. Numerous structures have been devastated, others suffered of damages. Keddara rockfill dam which is situated approximately at 20 km from the epicentre was strongly shaken during this seismic event and can undergo significant deformations. In this study, numerical analysis of Keddara rockfill dam under Boumerdes earthquake is performed. It is mainly focus on the seismic amplification at different level of the dam under the main shock with dominant frequency close to the natural frequency of the dam. The low coherence between the input and the structural output indicates the need of nonlinear analysis of the dam under the spatial variation in excitation. Furthermore, the effect of plasticity on the seismic response is investigated by using maximum acceleration which is one of the most important properties selected. The analysis of the dam under stochastic non-uniform excitation is conducted using a 2-D finite difference modeling by using the software Fast Lagrangian Analysis of Continua (FLAC). The final results obtained after successive analyses on the dam configuration incorporating the nonlinear soil properties are presented.
Nerves and muscles of the pregenital abdominal segments of the American cockroach, Periplaneta americana (L.)

The muscles and motor and sensory nerves of the pregenital abdominal segments were described and discussed in relation to the nerves and muscles of the thorax, as described by other workers. Each of the integumental muscles was named and described with regard to its location, function and innervation. Differences among segments of the same sex and between sexes were noted.
Prevalence, correlates, and trajectory of television viewing among infants and toddlers.

OBJECTIVES Recognizing the negative effects of television on children, the American Academy of Pediatrics (AAP) recommends that children 2 years and older watch <2 hours of television per day and that children younger than 2 years watch no television. However, relatively little is known about the amount of television viewed by infants and toddlers. The objective of this study was to describe the prevalence and correlates of television viewing that exceeds the AAP guidelines for 0- to 35-month-olds and to examine the trajectory of a child's viewing over time. METHODS Data from the National Longitudinal Survey of Youth, 1990 to 1998, were used to analyze reported television viewing at 0 to 35 months of age and to follow the trajectory of a child's viewing from infancy through age 6. Logistic regression models were used to determine risk factors associated with greater television viewing at 0 to 35 months and the association of early viewing habits with school-age viewing. RESULTS Seventeen percent of 0- to 11-month-olds, 48% of 12- to 23-month-olds, and 41% of 24- to 35-month-olds were reported to watch more television than the AAP recommends. Compared with college graduates, less-educated women were more likely to report that their children watched more television than recommended. Children who watched >2 hours per day at age 2 were more likely to watch >2 hours per day at age 6 (odds ratio: 2.7; 95% confidence interval: 1.8-3.9), controlling for maternal education, race, marital status and employment, household income, and birth order. CONCLUSIONS A substantial number of children begin watching television at an earlier age and in greater amounts than the AAP recommends. Furthermore, these early viewing patterns persist into childhood. Preventive intervention research on television viewing should consider targeting infants and toddlers and their families.
Compliance versus dead space for optimum positive end expiratory pressure determination in acute respiratory distress syndrome

Objective: To Compare compliance versus dead space (Vd) targeted positive end-expiratory pressure (PEEP) as regard its effect on lung mechanics and oxygenation. Materials and Methods: This study was carried out on 30 adult acute respiratory distress syndrome patients. The ventilator was initially set on volume controlled with tidal volume (Vt) 7 mL/kg predicted body weight (PBW), inspiratory plateau pressure (Ppl) <30 cm H2 O. If the Ppl was >30 cm H2 O with a TV of 6 mL/kg PBW, a step-wise Vt reduction of 1 mL/kg PBW to as low as 4 mL/kg/PBW was allowed. Respiratory rate adjusted to maintain pH 7.30-7.45. FiO2 start at 100%. Best PEEP determined at 2 points, one by titrating PEEP until reaching the highest static compliance (Cst) (PEEP Cst) and the other one is at the lowest Vd/Vt (PEEP Vd/Vt). The following data measured before and 30 min after setting PEEP Cst and PEEP Vd/Vt. Cst, PaCO2 - PetCO2, Vd/Vt, PaO2 /FiO2, Ppl, heart rate, mean arterial pressure and oxygen saturation. Results: optimum PEEP determined by Vd/Vt was significantly (P < 0.05) lower than the optimum PEEP determined by Cst. Best PEEP Vd/Vt showed a significant decrease (P < 0.05) in Cst, PaCO2 - PetCO2, Vd/Vt and Ppl in comparison with best PEEP Cst. The PaO2 /FiO2 showed a significant increase (P < 0.05) with best PEEP Vd/Vt in comparison with best PEEP Cst. Conclusion: Vd guided PEEP improved compliance and oxygenation with less Ppl. Hence, its use as a guide for best PEEP determination may be useful.
Designing technology for and with developmentally diverse children: a systematic literature review

This paper presents the results of a systematic literature review of research papers on the involvement of developmentally diverse children in design. The review shows that there is a growing tendency to include developmentally diverse children in the design process. Compared to other groups of developmentally diverse children, children with high-functioning autism between 8 and 12 years old are the ones that are most often actively involved in the design process. Other groups of children often have a more passive role, being observed, both in the requirements, design and evaluation phase. Working with mixed groups of children, either children with different disabilities, or typically developing children together with developmentally diverse children, also occurs more seldom. Compared to design with typically developing children, adults are involved more intensively in the design, either as users, proxies, experts and/or facilitators. Specific guidelines for how to prepare and perform design sessions with developmentally diverse children often emphasize the need for a coherence of activities, a clear structure in the sessions, verbal as well as textual explanations, and the active participation of caregivers, teachers and therapists. Based on these findings we give several suggestions for further research.
FLOW-INDUCED VIBRATIONS OF A LIGHT CIRCULAR CYLINDER AT REYNOLDS NUMBERS 103TO 104

Abstract Stabilized space–time finite-element methods are employed to investigate vortex-induced vibrations of a light circular cylinder placed in a uniform flow at Reynolds number in the range of 103–104. The governing equations for the fluid flow are the Navier–Stokes equations for incompressible flows. The cylinder is mounted on lightly damped, flexible supports and allowed to vibrate, both in the in-line and cross-flow directions under the action of aerodynamic forces. Results are presented for various values of the structural frequency of the oscillator including those that are super-harmonics of the vortex-shedding frequency for a stationary cylinder. In certain cases the effect of the mass of the oscillator is also examined. The motion of the cylinder alters the fluid flow significantly. To investigate the long-term dynamics of the non-linear oscillator, beyond the initial transient solution, long-time integration of the governing equations is carried out. For efficient utilization of the available computational resources the non-linear equation systems, resulting from the finite-element discretization of the flow equations, are solved using the preconditioned generalized minimal residual (GMRES) technique. Flows at lower Reynolds numbers are associated with organized wakes while disorganized wakes are observed at higher Reynolds numbers. In certain cases, competition is observed between various modes of vortex shedding. The fluid–structure interaction shows a significant dependence on the Reynolds number in the range that has been investigated in this article. In certain cases lock-in while in some other cases soft-lock-in is observed. The trajectory of the cylinder shows very interesting patterns including the well-known Lissajou figure of 8. Several mechanisms of the non-linear oscillator for self-limiting its vibration amplitude are observed.
The diagnostic value of neutrophil gelatinase-associated lipocalin and hepcidin in bacteria translocation of liver cirrhosis.

OBJECTIVE Bacterial translocation (BT) or bacterial DNA (bactDNA) translocation is a critical pathogenesis mechanism of spontaneous bacterial peritonitis. Studies of BT or bactDNA translocation are limited in humans. Neutrophil gelatinase associated lipocalin (NGAL) can efficiently distinguish bacterial and nonbacterial ascites in ascitic patients. Hepcidin is a useful marker of bacterial infection in the late-onset sepsis. However, the relationship between NGAL, hepcidin and BT was still unclear. In present study, the levels of NGAL, hepcidin and their relationship with BT or bactDNA translocation were investigated. MATERIAL AND METHODS Weekly doses of carbon tetrachloride (CCl4) were given to induce liver cirrhosis in Sprague-Dawley rats. Trypticase (blood) soy agars were used to culture bacteria. BactDNA was sequenced by ABIPRISM 310 automated sequencer. The levels of NGAL and hepcidin were assessed by ELISA. Receiver operating characteristic (ROC) curve was used to determine the cut-off values and compare the diagnostic performance of NGAL and hepcidin. RESULTS 56 cirrhotic and 10 normal rats were included in this study. The levels of both two biomarkers were significantly higher in BT or bactDNA translocation group compared to non-translocation group. The area under ROC curve for the diagnosis of BT was 0.910 for serum NGAL, 0.858 for serum hepcidin and 0.940 for their combination, whereas that for the diagnosis of bactDNA translocation was 0.906 for NGAL, 0.779 for hepcidin and 0.950 for their combination, respectively. The combination of NGAL and hepcidin improved the ability to detect BT or bactDNA presence in MLNs and ascites. CONCLUSION BT and the presence of bactDNA in MLNs were observed in a rat cirrhotic model. Serum NGAL and hepcidin can serve as sensitive and specific tests for diagnosis of BT or bactDNA translocation. NGAL in combination with hepcidin can improve the accuracy of diagnosis.
Quasistatic Evolution of Cavities in Nonlinear Elasticity

We show the well-posedness of a free-discontinuity model in nonlinear elasticity allowing for cavitation. The model, based on global minimization, takes into account the noninterpenetration of matter and the inhomogeneties of the material. Then we prove the existence of a quasi-static evolution corresponding to this variational model that takes into account the irreversibility of the process of the cavity formation.
CARLA: An Open Urban Driving Simulator

We introduce CARLA, an open-source simulator for autonomous driving research. CARLA has been developed from the ground up to support development, training, and validation of autonomous urban driving systems. In addition to open-source code and protocols, CARLA provides open digital assets (urban layouts, buildings, vehicles) that were created for this purpose and can be used freely. The simulation platform supports flexible specification of sensor suites and environmental conditions. We use CARLA to study the performance of three approaches to autonomous driving: a classic modular pipeline, an end-to-end model trained via imitation learning, and an end-to-end model trained via reinforcement learning. The approaches are evaluated in controlled scenarios of increasing difficulty, and their performance is examined via metrics provided by CARLA, illustrating the platform's utility for autonomous driving research. The supplementary video can be viewed at this https URL
Transfer Principle for the Fundamental Lemma

The purpose of this paper is to explain how the identities of various fundamental lemmas fall within the scope of the transfer principle, a general result that allows to transfer theorems about identities of p-adic integrals from one collection of fields to others. In particular, once the fundamental lemma has been established for one collection of fields (for example, fields of positive characteristic), it is also valid for others (fields of characteristic zero).
The Ideal Cardiovascular Health Metrics Associated Inversely with Mortality from All Causes and from Cardiovascular Diseases among Adults in a Northern Chinese Industrial City

Background and Aims The American Heart Association has recently established seven ideal cardiovascular health metrics for cardiovascular health promotion and disease reduction (i.e., non-smoking, normal body mass index, physically active, healthy diet, and normal levels of cholesterol, blood pressure and fasting blood glucose). The present study seeks to evaluate how well these metrics predict mortality from all causes and cardiovascular diseases in adult Chinese living in a northern industrial city. Methods and Results Data of 95,429 adults who participated in the Kailuan cohort study from June 2006 to October 2007 was analyzed. All participants underwent questionnaire assessment, clinical examination, laboratory assessments and were followed up biannually. During a median follow-up of 4.02 years, 1,843 deaths occurred, with 597 deaths resulting from cardiovascular diseases. Lower mortality rates from all causes and cardiovascular diseases were observed among the subjects who met a higher number of the ideal health metrics. Compared to the participants who met none or one ideal health metric, those meeting ≥5 ideal health metrics had a lower risk of all-cause mortality by 30% (adjusted hazard ratio, 0.70; 95% confidence interval, 0.56–0.88) and a lower risk of mortality from cardiovascular diseases by 39% (adjusted hazard ratio, 0.61; 95% confidence interval, 0.41–0.89) . Four metrics (smoking status, physical activity, blood pressure and fasting blood glucose) were significantly associated with all-cause mortality. Three metrics (physical activity, blood pressure and fasting blood glucose) were significantly associated with mortality from cardiovascular diseases. Conclusion The number of ideal health metrics is negatively associated with mortality rates from all causes and cardiovascular diseases among adults in a Northern Chinese industrial city. The data supports the AHA recommendation of ideal health metrics for adults from Northern China.
Event Detection in Twitter

Twitter, as a form of social media, is fast emerging in recent years. Users are using Twitter to report real-life events. This paper focuses on detecting those events by analyzing the text stream in Twitter. Although event detection has long been a research topic, the characteristics of Twitter make it a non-trivial task. Tweets reporting such events are usually overwhelmed by high flood of meaningless “babbles”. Moreover, event detection algorithm needs to be scalable given the sheer amount of tweets. This paper attempts to tackle these challenges with EDCoW (Event Detection with Clustering of Wavelet-based Signals). EDCoW builds signals for individual words by applying wavelet analysis on the frequencybased raw signals of the words. It then filters away the trivial words by looking at their corresponding signal autocorrelations. The remaining words are then clustered to form events with a modularity-based graph partitioning technique. Experimental results show promising result of EDCoW.
Cortical mechanisms of speech perception in noise.

PURPOSE The present study examines the brain basis of listening to spoken words in noise, which is a ubiquitous characteristic of communication, with the focus on the dorsal auditory pathway. METHOD English-speaking young adults identified single words in 3 listening conditions while their hemodynamic response was measured using fMRI: speech in quiet, speech in moderately loud noise (signal-to-noise ratio [SNR] 20 dB), and in loud noise (SNR -5 dB). RESULTS Behaviorally, participants' performance (both accuracy and reaction time) did not differ between the quiet and SNR 20 dB condition, whereas they were less accurate and responded slower in the SNR -5 dB condition compared with the other 2 conditions. In the superior temporal gyrus (STG), both left and right auditory cortex showed increased activation in the noise conditions relative to quiet, including the middle portion of STG (mSTG). Although the right posterior STG (pSTG) showed similar activation for the 2 noise conditions, the left pSTG showed increased activation in the SNR -5 dB condition relative to the SNR 20 dB condition. CONCLUSION We found cortical task-independent and noise-dependent effects concerning speech perception in noise involving bilateral mSTG and left pSTG. These results likely reflect demands in acoustic analysis, auditory-motor integration, and phonological memory, as well as auditory attention.