Miracle-dz/UniFAR-FTUs huggingface dataset:
Determining the Best Treatment for Coronal Angular Deformity of the Knee Joint in Growing Children: A Decision Analysis

This study aimed to determine the best treatment modality for coronal angular deformity of the knee joint in growing children using decision analysis. A decision tree was created to evaluate 3 treatment modalities for coronal angular deformity in growing children: temporary hemiepiphysiodesis using staples, percutaneous screws, or a tension band plate. A decision analysis model was constructed containing the final outcome score, probability of metal failure, and incomplete correction of deformity. The final outcome was defined as health-related quality of life and was used as a utility in the decision tree. The probabilities associated with each case were obtained by literature review, and health-related quality of life was evaluated by a questionnaire completed by 25 pediatric orthopedic experts. Our decision analysis model favored temporary hemiepiphysiodesis using a tension band plate over temporary hemiepiphysiodesis using percutaneous screws or stapling, with utilities of 0.969, 0.957, and 0.962, respectively. One-way sensitivity analysis showed that hemiepiphysiodesis using a tension band plate was better than temporary hemiepiphysiodesis using percutaneous screws, when the overall complication rate of hemiepiphysiodesis using a tension band plate was lower than 15.7%. Two-way sensitivity analysis showed that hemiepiphysiodesis using a tension band plate was more beneficial than temporary hemiepiphysiodesis using percutaneous screws.
A Central Role of Salicylic Acid in Plant Disease Resistance

Transgenic tobacco and Arabidopsis thaliana expressing the bacterial enzyme salicylate hydroxylase cannot accumulate salicylic acid (SA). This defect not only makes the plants unable to induce systemic acquired resistance, but also leads to increased susceptibility to viral, fungal, and bacterial pathogens. The enhanced susceptibility extends even to host-pathogen combinations that would normally result in genetic resistance. Therefore, SA accumulation is essential for expression of multiple modes of plant disease resistance.
Disenfranchised grief: the emotional impact experienced by foster carers on the cessation of a placement

This study uses a qualitative approach to explore the experiences of 22 UK foster carers when a child is ‘moved on’ from a placement, focusing specifically on their experiences of loss. In most cases participants report loving the child as their own and describe their surprise at the profundity of their feelings of loss and grief when living through the child’s departure. These emotions can be fruitfully perceived as ‘disenfranchised grief’ in that its severity was unexpected and was not recognised as legitimate by the carers’ social group or professionals working with them. As a result, their loss was neither perceived as legitimate nor given a vehicle for expression. In some cases, participants report that the experience changed their approach to caring for children and even resulted in them ceasing to foster. The implications for practice include preparing foster carers to expect a grief response when their children move on, to recognise that this might be disenfranchised and to enhance peer and professional support during that process.
Correction: Validation of a preclinical model for assessment of drug efficacy in melanoma

The aim of personalized medicine is to improve our understanding of the disease at molecular level and to optimize therapeutic management. In this context, we have developed in vivo and ex vivo preclinical strategies evaluating the efficacy of innovative drugs in melanomas. Human melanomas (n = 17) of different genotypes (mutated BRAF, NRAS, amplified cKIT and wild type) were successfully engrafted in mice then amplified by successive transplantations. The exhaustive characterization of patient-derived xenografts (PDX) at genomic level (transcriptomic and CGH arrays) revealed a similar distribution pattern of genetic abnormalities throughout the successive transplantations compared to the initial patient tumor, enabling their use for mutation-specific therapy strategies. The reproducibility of their spontaneous metastatic potential in mice was assessed in 8 models. These PDXs were used for the development of histoculture drug response assays (ex vivo) for the evaluation of innovative drug efficacy (BRAF and MEK inhibitors). The pharmacological effects of BRAF and MEK inhibitors were similar between PDX-derived histocultures and their corresponding PDX, on 2 models of BRAF and NRAS-mutated melanomas. These models constitute a validated, effective tool for preclinical investigation of new therapeutic agents, and improve therapeutic strategies in the treatment of metastatic
Preoperative Predictors of Ambulation Ability at Different Time Points after Total Hip Arthroplasty in Patients with Osteoarthritis

The aims of this study were to identify the preoperative factors influencing ambulation ability at different postoperative time points after total hip arthroplasty (THA) and to examine the cutoff values of predictive preoperative factors by receiver operating characteristic (ROC) curves. Forty-eight women with unilateral THA were measured for hip extensor, hip abductor, and knee extensor muscle strength in both legs; hip pain (visual analog scale, VAS); and the Timed Up and Go (TUG) test pre- and postoperatively. Multiple regression analysis indicated that preoperative knee extensor strength (β = −0.379, R 2 = 0.409) at 3 weeks, hip abductor strength (β = −0.572, R 2 = 0.570) at 4 months, and age (β = 0.758, R 2 = 0.561) at 7 months were strongly associated with postoperative ambulation, measured using the TUG test. Optimal preoperative cutoff values for ambulation ability were 0.56 Nm/kg for knee extensor strength, 0.24 Nm/kg for hip abductor strength, and 73 years of age. Our results suggest that preoperative factors predicting ambulation ability vary by postoperative time point. Preoperative knee extensor strength, hip abductor strength, and age were useful predictors of ambulation ability at the early, middle, and late time points, respectively, after THA.
Children’s participation in Dutch youth care practice: an exploratory study into the opportunities for child participation in youth care from professionals’ perspective

ABSTRACT Since 2015, local municipalities in the Netherlands have been responsible for the organisation of the youth care and child protection system. One of the basic assumptions underlying the new Youth Act (2015) is the mobilisation and empowerment of the family to help solve their problems. Consequently, the participation of children and parents is essential in the implementation of youth care services. However, it seems that substantial differences exist between municipalities in realising children's participation in decisions that are taken concerning their care and protection. This article provides an interdisciplinary perspective on child participation; it explores both the legal opportunities for participation and the extent to which children can make use of these opportunities in practice. It is concluded that municipalities have large discretion in giving shape to child participation in the access to voluntary and coercive youth care. However, child participation is better regulated and implemented in practice with respect to compulsory youth care via court orders. Throughout almost the entire process, the minimum age limit from when children are involved in the decision-making process is 12 years, which means that children below that age have scarce opportunities to participate.
Endothelial Dysfunction of Bypass Graft: Direct Comparison of In Vitro and In Vivo Models of Ischemia-Reperfusion Injury

BACKGROUND Although, ischemia/reperfusion induced vascular dysfunction has been widely described, no comparative study of in vivo- and in vitro-models exist. In this study, we provide a direct comparison between models (A) ischemic storage and in-vitro reoxygenation (B) ischemic storage and in vitro reperfusion (C) ischemic storage and in-vivo reperfusion. METHODS AND RESULTS Aortic arches from rats were stored for 2 hours in saline. Arches were then (A) in vitro reoxygenated (B) in vitro incubated in hypochlorite for 30 minutes (C) in vivo reperfused after heterotransplantation (2, 24 hours and 7 days reperfusion). Endothelium-dependent and independent vasorelaxations were assessed in organ bath. DNA strand breaks were assessed by TUNEL-method, mRNA expressions (caspase-3, bax, bcl-2, eNOS) by quantitative real-time PCR, proteins by Western blot analysis and the expression of CD-31 by immunochemistry. Endothelium-dependent maximal relaxation was drastically reduced in the in-vivo models compared to ischemic storage and in-vitro reperfusion group, and no difference showed between ischemic storage and control group. CD31-staining showed significantly lower endothelium surface ratio in-vivo, which correlated with TUNEL-positive ratio. Increased mRNA and protein levels of pro- and anti-apoptotic gens indicated a significantly higher damage in the in-vivo models. CONCLUSION Even short-period of ischemia induces severe endothelial damage (in-vivo reperfusion model). In-vitro models of ischemia-reperfusion injury can be limitedly suited for reliable investigations. Time course of endothelial stunning is also described.
Academics’ experience of contradicting institutional logics of publishing

Purpose The purpose of this paper is to explore whether and how Ukrainian scholars recognize and react to a situation of an absence of two major institutional logics of academic writing and publishing, namely the logics of science advancement and personal career promotion and the dominance of the logic of coercive pressures to publish regardless of quality and resonance and with no material and reputational rewards. Two fundamental and essential logics that drive research activity at any university in western societies seem to be almost absent in Ukrainian context, where symbolic publishing for accountability only is taken-for-granted. Design/methodology/approach The study adopts qualitative interpretative research methodology. The scholars from seven universities were interviewed, including 16 senior scholars and 15 PhD students. Findings The study shows the dominance of a single logic of accountability which is persisted due to coercive pressures exerted on scholars. Despite the absence of instrumental value behind publishing requirements in Ukrainian higher education system, most academics do not question this policy and largely take it for granted as the only possible system. Originality/value Research conducted in this study contributes to institutional logics and institutional complexity literature by highlighting a unique situation of institutional complexity when logic that offers neither economic nor social benefits dominates the field. It is shown how actors recognize, interpret and respond to this situation, identifying three types of responses that range from blind adherence to taken-for-granted institutional definitions to strategic balance between coercive pressures and desired logics.
Effects of Schema Therapy and Schema-Focused Mindfulness Therapy on Conflict Resolution of Iranian Women in Malaysia

This study aimed to investigate the effectiveness of schema therapy and schema-focused mindfulness therapy on conflict resolution among Iranian married women who lived in Malaysia during ? 2015-2016. The qualified participants included 96 women who were assigned randomly into three groups, i.e. two experimental groups and a control group. The first experimental group received schema therapy and the second group received schema-focused mindfulness therapy while the control group did not receive any treatment. The treatment sessions lasted nearly three months using conflict resolution subscale from the ENRICH questionnaire, a demographic questionnaire and Young's schema questionnaire as the instruments. Two-way repeated measures ANOVA was also applied to analyze the results. The findings of the study revealed that schema therapy and schema-focused mindfulness therapy had a significant effect on conflict resolution of Iranian women in Malaysia. Moreover, the findings showed more improvement for schema-focused mindfulness therapy group at two months follow-up.
QUANTITATIVE 3D RECONSTRUCTIONS AS IDENTIFICATION TOOL IN HEART DEVELOPMENT

A method for displaying quantitative information in 3D reconstructions of the embryonic heart was developed to investigate spatial distributions of cell division and cell density. The method utilizes serial sections to extract morphological as well as quantitative data. The morphological data are used to reconstruct the embryonic heart and the quantitative data are classified and superimposed on the resulting reconstruction. The bias, which would result from size differences between cell populations, was investigated. If present, it would influence the absolute number of particles (nuclei) per volume, although the classification applied on the reconstruction displaying the mitotic fraction remains unchanged. Although the reconstruction displaying the local densities is influenced by the bias, less than 2.5% of the regions is misclassified.
Combining Rasterization and Ray Tracing Techniques to Approximate Global Illumination in Real-Time

With the advent of modern processing hardware, it became possible to bring global illumination effects into real-time applications. Namely, several classic global illumination algorithms were recently adapted to run in real-time on the GPU while ray tracing has also become suitable for real-time rendering on the CPU. Although none of these techniques provides a complete solution for simulating illumination in a realistic way, each one of them provides a different but complementary contribution for achieving this purpose. In this line of thought, this thesis introduces a 3D rendering engine that combines GPU rasterization and CPU ray tracing techniques in order to approximate global illumination in real-time. The engine simulates direct lighting using typical local illumination models while it simulates indirect lighting through an implementation of the light propagation volumes technique and a new sky lighting technique that is presented in this thesis which provides realistic indirect lighting for outdoor environments. These illumination effects are then complemented by sharp reflections and refractions generated by an hybrid real-time ray tracer that combines the processing power of the CPU and the GPU to generate these effects efficiently and to combine them seamlessly with the rest of the lighting.
Gaming Emotions 1 Gaming Emotions Working paper

One’s own emotions may influence others’ behavior in a given social interaction. If one believes this, s/he has an incentive to game emotions—to strategically conceal a current emotion or display a non-experienced emotion—in an attempt to influence her/his counterpart. In a series of three experiments, we show that people deliberately conceal (experiment 1) or misrepresent (experiments 2 and 3) their emotional state in a negotiation setting. When given the opportunity to either hide or express their current emotions before playing an ultimatum game, receivers who have reported low (vs. high) level of anger are more likely to conceal their emotion right before the proposers decide on the division of the pie (experiment 1). When the procedure allows participants to change their previously reported emotion, receivers choose to inflate their reported level of anger prior to proposers’ decision (experiment 2). Finally, this emotion gaming hypothesis generalizes to positive emotions as well. In a standard trust game, trustees inflate the level of happiness before trusters decide on passing vs. keeping a fixed amount of money to the trustees (experiment 3).
Impaired Neuronal Positioning and Dendritogenesis in the Neocortex after Cell-Autonomous Dab1 Suppression

Reelin and Disabled 1 (Dab1) are essential for positioning migrating neurons in the developing neocortex. Cell-autonomous RNA interference-mediated suppression of Dab1 in migrating neurons destined for layer 2/3 shifted the median position of these cells to deeper positions within the cortex. At the time of migration arrest [embryonic day 20 (E20) to E21], Dab1-suppressed cells were underrepresented in the upper ∼40 μm of the cortex compared with controls, suggesting that Dab1 is essential for somal translocation through the cell-dense cortical plate. Closer examination of the morphology of Dab1-suppressed neurons at E20 revealed simplified leading processes that are less likely to contact the marginal zone (MZ), in which high levels of Reelin are expressed. Examination of Dab1-suppressed cells 3 d later (postnatal day 2) revealed simplified dendrites that are also less likely to contact the MZ. These data reveal a cell-autonomous role of Dab1 in dendritogenesis in the neocortex and suggest that remodeling of the leading process of a migrating neuron into a nascent dendrite by Reelin/Dab1 signaling plays an important role in cell positioning.
The Status of Dietary Supplements Intake in Korean Preschool Children: Data from the Korea National Health and Nutrition Examination Survey 2010-2012

Purpose The use of dietary supplements (DS) has increased in most nations. We investigated the amount of DS intake in the Korean population by analyzing a national survey, to support the preparation of a national institutional strategy regarding DS intake and marketing. Methods The data of the fifth Korea National Health and Nutrition Examination Survey (a year between 2010 and 2012) were investigated, analyzing the rate of DS intake, and the characteristics of the intake group and non-intake group in Korean preschool children. Results The intake rate of DS was 49.0-54.2% (1,313,874-1,491,240) and 19.6-30.3% (250,603-421,922) in children from 1 to 6 years old and in those less than 1 year, respectively, from 2010 to 2012. The highest intake rate was observed in the age group of five. The mean age was significantly higher in the DS intake group than in the non-intake group. Intake of essential nutrients, minerals, and vitamins were also higher in the DS intake group. The level of family income was significantly associated with the intake rate (p<0.001). In children less than 1 year, probiotics accounted for the highest intake of DS. Conclusion Korean preschool children have high consumption of DS. Therefore, problems may arise from the waste of money purchasing unnecessary DS, and from the overuse of DS in preschoolers who do not require DS intake. We hope these results can be used to produce an appropriate national institutional strategy regarding DS intake and marketing.
Tailoring Particle Size and Agglomeration State of Mesoporous MCM-48 via Optimisation of Sol-gel Silica Process

Mobil Composition of Matter no. 48 (MCM-48) is a promising inorganic particle due to its unique crystal structure and 3-dimensional porous network. Incorporating a discrete amount of nanosized MCM-48 for material development would give significant impact to the material’s performance and mechanical robustness. Thus far, the synthesis of MCM-48 in the nanoscale regime has been achieved via chemical modification techniques. However, they are often not reproducible due to limited understanding of surfactant behaviour. On the other hand, physical modification technique is more stable, thereby can reduce the possibility of producing other undesired mesophase. Nevertheless, this technique has not been adapted for nanosized MCM-48 synthesis. In this work, the physical modification technique was adapted to tailor MCM-48 particle size by varying stirring speed (i.e., 1000 rpm, 3000 rpm and 5000 rpm) and using different types of washing medium. Particle size distribution (PSD) studies showed mean particle size of 250 ± 50 nm. XRD analysis displayed several crystalline peaks indexed to cubic crystal mesophase. Transmission electron microscopy (TEM) and Brunauer-Emmett Teller (BET) analyses also showed a unique 3D cubic interconnecting porous network with specific surface area of 1030 m2 g–1. It was revealed that the degree of agglomeration increased as relative polarity of alcohol increased, CH3OH > CH3CH2OH. Therefore, particle size and agglomeration state of MCM-48 can be tailored by varying the physical modification techniques while maintaining its intrinsic pore morphology.
Strongly Adaptive Regret Implies Optimally Dynamic Regret

To cope with changing environments, recent developments in online learning have introduced the concepts of adaptive regret and dynamic regret independently. In this paper, we illustrate an intrinsic connection between these two concepts by showing that the dynamic regret can be expressed in terms of the adaptive regret and the functional variation. This observation implies that strongly adaptive algorithms can be directly leveraged to minimize the dynamic regret. As a result, we present a series of strongly adaptive algorithms whose dynamic regrets are minimax optimal for convex functions, exponentially concave functions, and strongly convex functions, respectively. To the best of our knowledge, this is the first time that such kind of dynamic regret bound is established for exponentially concave functions. Moreover, all of those adaptive algorithms do not need any prior knowledge of the functional variation, which is a significant advantage over previous specialized methods for minimizing dynamic regret.
ST ] 2 1 Ja n 20 07 Bayesian shrinkage prediction for the regression problem

We consider Bayesian shrinkage predictions for the Normal regression problem under the frequentist Kullback-Leibler risk function. Firstly, we consider the multivariate Normal model with an unknown mean and a known covariance. While the unknown mean is fixed, the covariance of future samples can be different from training samples. We show that the Bayesian predictive distribution based on the uniform prior is dominated by that based on a class of priors if the prior distributions for the covariance and future covariance matrices are rotation invariant. Then, we consider a class of priors for the mean parameters depending on the future covariance matrix. With such a prior, we can construct a Bayesian predictive distribution dominating that based on the uniform prior. Lastly, applying this result to the prediction of response variables in the Normal linear regression model, we show that there exists a Bayesian predictive distribution dominating that based on the uniform prior. Minimaxity of these Bayesian predictions follows from these results.