Miracle-dz/UniFAR-FTUs huggingface dataset:
Origins of endemic stickleback from the Queen Charlotte Islands: mitochondrial and morphological evidence

Recently, two divergent mitochondrial lineages were described in a survey of 12 scattered populations of the threespine stickleback (Gasterosteus aculeatus) on the Queen Charlotte Islands (QCI), western Canada, one of which, possibly a relict lineage, was subsequently shown to characterize stickleback from the western Pacific near Japan. In the present study, we assayed 985 fish from 85 QCI populations for mitochondrial lineage using a restriction enzyme test. Our data indicate that the relict lineage was largely limited (18 of 20 populations) to adjacent watersheds in the northeast corner of the QCI close to a suspected glacial refugium, but we also found the lineage in two remote lakes on the west coast of the QCI, distant from any known refugia. We obtained a sample of 33 stickleback from the mid-Pacific and found both mitochondrial DNA (mtDNA) lineages, strongly suggesting ongoing dispersal of these fish across the Pacific, and inconsistent with previous suggestions of relict status for one of the lineages. Morphologically derived traits, such as loss of armour and loss of spines, occurred in both lineages, but these were more prevalent in the Japanese lineage. Surprisingly, 19 localities had both lineages, and within each of these there were no significant univariate or multivariate associations between lineages and morphology, suggesting few if any reproductive barriers between the divergent mtDNA lineages. RCsumC : RCcemment, deux lignCes mitochondriales divergentes ont CtC dCcrites i partir d'un inventaire de 12 populations dispersCes de 1'~~inoche i trois Cpines (Gasterosteus aculeatus) dans les iles de la Reine-Charlotte, dans I'Ouest
Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction.

AIMS Clinical studies suggest that intake of omega-3 polyunsaturated fatty acids (omega-3 PUFA) may lower the incidence of heart failure. Dietary supplementation with omega-3 PUFA exerts metabolic and anti-inflammatory effects that could prevent left ventricle (LV) pathology; however, it is unclear whether these effects occur at clinically relevant doses and whether there are differences between omega-3 PUFA from fish [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] and vegetable sources [alpha-linolenic acid (ALA)]. METHODS AND RESULTS We assessed the development of LV remodelling and pathology in rats subjected to aortic banding treated with omega-3 PUFA over a dose range that spanned the intake of humans taking omega-3 PUFA supplements. Rats were fed a standard food or diets supplemented with EPA+DHA or ALA at 0.7, 2.3, or 7% of energy intake. Without supplementation, aortic banding increased LV mass and end-systolic and -diastolic volumes. ALA supplementation had little effect on LV remodelling and dysfunction. In contrast, EPA+DHA dose-dependently increased EPA and DHA, decreased arachidonic acid in cardiac membrane phospholipids, and prevented the increase in LV end-diastolic and -systolic volumes. EPA+DHA resulted in a dose-dependent increase in the anti-inflammatory adipokine adiponectin, and there was a strong correlation between the prevention of LV chamber enlargement and plasma levels of adiponectin (r = -0.78). Supplementation with EPA+DHA had anti-aggregatory and anti-inflammatory effects as evidenced by decreases in urinary thromboxane B(2) and serum tumour necrosis factor-alpha. CONCLUSION Dietary supplementation with omega-3 PUFA derived from fish, but not from vegetable sources, increased plasma adiponectin, suppressed inflammation, and prevented cardiac remodelling and dysfunction under pressure overload conditions.
Differential response of human dermal fibroblast subpopulations to visible and near‐infrared light: Potential of photobiomodulation for addressing cutaneous conditions

The past decade has witnessed a rapid expansion of photobiomodulation (PBM), demonstrating encouraging results for the treatment of cutaneous disorders. Confidence in this approach, however, is impaired not only by a lack of understanding of the light‐triggered molecular cascades but also by the significant inconsistency in published experimental outcomes, design of the studies and applied optical parameters. This study aimed at characterizing the response of human dermal fibroblast subpopulations to visible and near‐infrared (NIR) light in an attempt to identify the optical treatment parameters with high potential to address deficits in aging skin and non‐healing chronic wounds.
Universality in statistics of Stokes flow over a no-slip wall with random roughness

Stochastic roughness is a widespread feature of natural surfaces and is an inherent byproduct of most fabrication techniques. In view of the rapid development of microfluidics, the important question is how this inevitable problem affects the low-Reynolds-number flows that are common for micro-devices. Moreover, one could potentially turn the flaw into a virtue and control the flow properties by means of specially ‘tuned’ random roughness. In this paper we investigate theoretically the statistics of fluctuations in fluid velocity produced by the waviness irregularities at the surface of a no-slip wall. Particular emphasis is laid on the issue of the universality of our findings.
Patient satisfaction at the Muhimbili National Hospital in Dar es Salaam, Tanzania.

OBJECTIVES Patients are the primary beneficiaries of the services and care that hospitals provide. The Patient Satisfaction study examined the extent to which patients at the Muhimbili National Hospital (MNH) were satisfied with the services and care they received at MNH. This was part of a baseline study that sought to determine the level of performance of the hospital before massive restructuring, reform, and renovations were undertaken. METHODOLOGY Exit interviews were the main research method used to determine patient satisfaction. Patients were interviewed as they were leaving the OPD clinics, laboratory, X-ray, pharmacy and inpatient wards. RESULTS The study found that most patients were satisfied with the services and care they received. This high level of satisfaction must be viewed within the context of a hierarchical public health care delivery system, with MNH at the apex. The services and care MNH provides can only be excellent compared to that provided by lower level health facilities. Indeed, patients covered by this study perceived the services provided by MNH as superior, and this was reflected in the high level of satisfaction they reported. Some patients expressed dissatisfaction with specific aspects of the services that they received. They were particularly dissatisfied with long waiting times before receiving services, the high costs of treatment and investigations charged at MNH, poor levels of hygiene in the wards, and negative attitudes of staff towards patients. CONCLUSION Although only a small proportion of patients expressed dissatisfaction with these aspects of the services provided, they are significant in that they constitute a call for action by the MNH management to encourage the health personnel to embrace a new staff-patient relationship ethos, in which the patient is a viewed as a customer.
Serum Glycine Is Associated with Regional Body Fat and Insulin Resistance in Functionally-Limited Older Adults

Background Metabolic profiling may provide insight into biologic mechanisms related to age-related increases in regional adiposity and insulin resistance. Objectives The objectives of the current study were to characterize the association between mid-thigh intermuscular and subcutaneous adipose tissue (IMAT, SCAT, respectively) and, abdominal adiposity with the serum metabolite profile, to identify significant metabolites as further associated with the homeostasis model assessment of insulin resistance (HOMA-IR), and, to develop a HOMA-IR associated metabolite predictor set representative of regional adiposity, in 73 functionally-limited (short physical performance battery ≤10; SPPB) older adults (age range, 70–85 y). Methods Fasting levels of 181 total metabolites, including amino acids, fatty acids and acylcarnitines were measured with use of an untargeted mass spectrometry-based metabolomic approach. Multivariable-adjusted linear regression was used in all analyses. Results Thirty-two, seven and one metabolite(s) were found to be associated with IMAT, abdominal adiposity and, SCAT, respectively, including the amino acid glycine, which was positively associated with SCAT and, negatively associated with both IMAT and abdominal adiposity. Glycine and four metabolites found to be significantly associated with regional adiposity were additionally associated with HOMA-IR. Separate stepwise regression models identified glycine as a HOMA-IR associated marker of both IMAT (model R2 = 0.51, p<0.0001) and abdominal adiposity (model R2 = 0.41, p<0.0001). Conclusion Our findings for a positive association between glycine with SCAT but, a negative association between glycine with IMAT and abdominal adiposity supports the hypothesis that SCAT metabolic processes are different from that found in other fat depots. In addition, because of the significant associations found between glycine with HOMA-IR, IMAT, SCAT and abdominal adiposity, our results suggest glycine as a serum biomarker of both insulin sensitivity and regional fat mass in functionally-limited older adults.
Extracellular loop structures in silkworm ABCC transporters determine their specificities for Bacillus thuringiensis Cry toxins

Bacillus thuringiensis Cry toxins are insecticidal proteins used widely for pest control. They are lethal to a restricted range of insects via specific interactions with insect receptors such as the ABC transporter subfamily members C2 (ABCC2) and C3 (ABCC3). However, it is still unclear how these different receptors contribute to insect susceptibility to Cry1A toxins. Here, we investigated the differences between the silkworm (Bombyx mori) ABCC2 (BmABCC2_S) and ABCC3 (BmABCC3) receptors in mediating Cry toxicity. Compared with BmABCC2_S, BmABCC3 exhibited 80- and 267-fold lower binding affinities to Cry1Aa and Cry1Ab, respectively, and these decreased affinities correlated well with the lower receptor activities of BmABCC3 for these Cry1A toxins. To identify the amino acid residues responsible for these differences, we constructed BmABCC3 variants containing a partial amino acid replacement with extracellular loops (ECLs) from BmABCC2_S. Replacing three amino acids from ECL 1 or 3 increased BmABCC3 activity toward Cry1Aa and enabled its activity toward Cry1Ab. Meanwhile, BmABCC2_S and BmABCC3 exhibited no receptor activities for Cry1Ca, Cry1Da, and Cry3Bb, correlating with markedly lower binding affinities for these Cry toxins. ABCC2 from a Cry1Ab-resistant B. mori strain (BmABCC2_R), which has a tyrosine insertion in ECL 2, displayed 93-fold lower binding affinity to Cry1Ab compared with BmABCC2_S but maintained high binding affinity to Cry1Aa. These results indicate that the Cry toxin–binding affinities of ABCC transporters are largely linked to the level of Cry susceptibility of ABCC-expressing cells and that the ABCC ECL structures determine the specificities to Cry toxins.
Contralateral Hemisphere Activation by Unilateral Hand Contraction: ReExamining Global and Local Attention

While previous studies have shown that left- (vs. right-) hand contractions can improve the performance of global (vs. local) attention, these results were inconsistent in certain behavioral studies in which the left cerebral hemisphere was found to be specialized for local attention, while the right hemisphere was not specialized for global attention. Thus, we reexamined whether different global (vs. local) attention performances follow left- (vs. right-) hand contractions due to right (vs. left) hemisphere activation. We recruited 100 right-handed healthy female, university student (aged 19–26 years) participants. We used the Navon task to present 80 letter-stimuli (40 in the global task; 40 in the local task) to either the participants’ left or right visual fields. Half of the participants (randomly selected) were instructed to squeeze a dynamometer with the left hand, while the other half squeezed with the right hand, prior to completing the Navon task. In line with previous research, we observed a perceptual advantage of global (large letters) over local (small letters) stimuli. Participants who contracted the right hand showed an enhanced local attention performance (from left hemisphere activation), whereas those who contracted the left hand did not improve global attention performance (from right hemisphere activation). Thus, we supported prior behavioral research suggesting that hemispheric asymmetry for attention processing is evident for left but not right cortical hemisphere processing.
Random matrices, free probability and the replica method

This survey gives an overview of analytic tools to the design, analysis, and modelling of communication systems which can be described by linear vector channels such as y = Hx + z where the number of components in each vector is large. Tools from probability theory, operator algebra, and statistical physics are reviewed. Asymptotic eigenvalue distributions of some classes of random matrices are given in terms of densities, moments and/or Stieltjes transforms. Free probability theory which evolved from non-commutative operator algebras is explained from a probabilistic point of view in order to better fit the engineering community. For that purpose freeness is defined without reference to non-commutative algebras. The treatment includes additive and multiplicative free convolution, the R-transform, and the S-transform. The replica method developed in statistical physics for the purpose of analyzing spin glasses is reviewed from the view point of its applications in communications engineering. Correspondences between free energy and mutual information as well as energy functions and detector metrics are established.
The CiCs(SiI)n Defect in Silicon from a Density Functional Theory Perspective

Carbon constitutes a significant defect in silicon (Si) as it can interact with intrinsic point defects and affect the operation of devices. In heavily irradiated Si containing carbon the initially produced carbon interstitial–carbon substitutional (CiCs) defect can associate with self-interstitials (SiI’s) to form, in the course of irradiation, the CiCs(SiI) defect and further form larger complexes namely, CiCs(SiI)n defects, by the sequential trapping of self-interstitials defects. In the present study, we use density functional theory to clarify the structure and energetics of the CiCs(SiI)n defects. We report that the lowest energy CiCs(SiI) and CiCs(SiI)2 defects are strongly bound with −2.77 and −5.30 eV, respectively.
Robust Estimation of Skin Pigmentation from Facial Color Images Based on Color Constancy

pigment separation algorithms based on independent component analysis (ICA) have been proposed. Their key limitation lies in not only the lack of robust estimation of skin pigmentation, melanin and hemoglobin, under different illumination, but also the inefficiency of the algorithm. In this paper, we propose a new method for estimating the concentration of skin pigmentation, combining with the known color constancy algorithm which is applied to the skin image as the preprocessing to remove the color interference from illumination. And as an improvement of the conventional pigment separation algorithm, we propose a new verification rule of pure color intensities matrix, discarding the complex computations of distinguishing the vectors of the pure color intensities matrix which correspond to melanin and hemoglobin components. Finally, we qualitatively evaluate the concentration distribution corresponding to melanin and hemoglobin, and compare the results of before and after using the color constancy algorithm. The experiments show that our algorithm obtains comparable results as the state-of-the-art pigment separation methods with the merit of higher efficiency and robustness against change in illumination.
A Physics-Based Power Model for Skid-Steered Wheeled Mobile Robots

The power consumed by skid-steered mobile robots varies enormously depending on their operating regimes and environments. Therefore, energy optimal planning of field missions can be accomplished only if the operating environment and an accurate model of the robot's power consumption are known in advance. This paper studies influences of location of the center of mass, surface type, terrain relief, platform geometry, radius of curvature, speed, and temperature on the power consumption of a skid-steered mobile platform and derives a physics-based power model that uses friction to accurately model the power consumed for the most relevant parameters inside a wide range of operating conditions. This paper also shows how friction can be measured using power consumed by the motors and how motor constants can be measured in a noninvasive end-to-end manner. Our findings were validated with a Clearpath's Husky A200 platform, driving it indoors and outdoors on different surfaces, varying the speed, the radius of curvature, the mass, and the center of mass location, resulting in a dense dataset on which the derived model as well as the temperature dependence of the power consumption was verified.
Prediction of GPCR-Ligand Binding Using Machine Learning Algorithms

We propose a novel method that predicts binding of G-protein coupled receptors (GPCRs) and ligands. The proposed method uses hub and cycle structures of ligands and amino acid motif sequences of GPCRs, rather than the 3D structure of a receptor or similarity of receptors or ligands. The experimental results show that these new features can be effective in predicting GPCR-ligand binding (average area under the curve [AUC] of 0.944), because they are thought to include hidden properties of good ligand-receptor binding. Using the proposed method, we were able to identify novel ligand-GPCR bindings, some of which are supported by several studies.
Unveiling the Structure of MoSx Nanocrystals Produced upon Laser Fragmentation of MoS2 Platelets

Transition-metal dichalcogenide MoS2 nanostructures have attracted tremendous attention due to their unique properties, which render them efficient nanoscale functional components for multiple applications ranging from sensors and biomedical probes to energy conversion and storage devices. However, despite the wide application range, the possibility to tune their size, shape, and composition is still a challenge. At the same time, the correlation of the structure with the optoelectronic properties is still unresolved. Here, we propose a new method to synthesize various morphologies of molybdenum sulfide nanocrystals, on the basis of ultrashort-pulsed laser fragmentation of MoS2 platelets. Depending on the irradiation conditions, multiple MoSx morphologies in the form of nanoribbons, nanospheres, and photoluminescent quantum dots are obtained. Besides the detailed structural analysis of the various crystals formed, the structure–property relation is investigated and discussed.
Fog Prediction from a Multimodel Mesoscale Ensemble Prediction System

Abstract A new multivariable-based diagnostic fog-forecasting method has been developed at NCEP. The selection of these variables, their thresholds, and the influences on fog forecasting are discussed. With the inclusion of the algorithm in the model postprocessor, the fog forecast can now be provided centrally as direct NWP model guidance. The method can be easily adapted to other NWP models. Currently, knowledge of how well fog forecasts based on operational NWP models perform is lacking. To verify the new method and assess fog forecast skill, as well as to account for forecast uncertainty, this fog-forecasting algorithm is applied to a multimodel-based Mesoscale Ensemble Prediction System (MEPS). MEPS consists of 10 members using two regional models [the NCEP Nonhydrostatic Mesoscale Model (NMM) version of the Weather Research and Forecasting (WRF) model and the NCAR Advanced Research version of WRF (ARW)] with 15-km horizontal resolution. Each model has five members (one control and four perturbed mem.
Perceptual Discrimination of Basic Object Features Is Not Facilitated When Priming Stimuli Are Prevented From Reaching Awareness by Means of Visual Masking

Our understanding of how form, orientation and size are processed within and outside of awareness is limited and requires further investigation. Therefore, we investigated whether or not the visual discrimination of basic object features can be influenced by subliminal processing of stimuli presented beforehand. Visual masking was used to render stimuli perceptually invisible. Three experiments examined if visible and invisible primes could facilitate the subsequent feature discrimination of visible targets. The experiments differed in the kind of perceptual discrimination that participants had to make. Namely, participants were asked to discriminate visual stimuli on the basis of their form, orientation, or size. In all three experiments, we demonstrated reliable priming effects when the primes were visible but not when the primes were made invisible. Our findings underscore the importance of conscious awareness in facilitating the perceptual discrimination of basic object features.
Looking for the Best Indicator Fetal Malnutrition: An Overview

In this paper we discuss the common methods available for identification of the malnourished fetuses at birth. We recommend that the CANS and the based CANSCORE which is purely clinical be routinely used. This will remove the bias caused by birthweight which vary from one region to another. Features of malnutrition are the same whether in Nigerians, Americans or Indians.
Effect of Solvent on the Physical and Morphological Properties of Poly(Lactic Acid) Nanofibers Obtained by Solution Blow Spinning

Solution blow spinning (SBS) is a simple, safe, and inexpensive alternative to electrospinning for making nanofibers from polymer solutions. However, since SBS is a relatively new technique, there is a general lack of information on polymer solutions and properties that affect fiber morphology and intrinsic properties. The present study reports the solution properties of poly (lactic acid) (PLA) dissolved in chloroform, dichloromethane, and dichloroethane at 4%, 6%, or 8% (w/v) and the properties of fibers made by SBS. In contrast to 4% polymer solutions, fibers made from 6% polymer solutions had few beads and diameters in the range of 120–320 nm. Diameters were greater (311–570 nm) for fibers made from 8% polymer solutions. Solvent evaporation rate affected the fiber porosity and formation. Hansen solubility parameters indicate that dichloromethane was the solvent most miscible with PLA. Fibers made with PLA in dicloromethane had the broader range in fiber diameter. Hansen parameters could be a valuable predictive tool for identifying highly miscible polymer/solvent systems for the SBS process. Polymer solutions with high viscoelasticity and viscosity were well suited for the SBS process. Fibers made from polymer solutions containing dichloromethane had lower crystallinity compared to fibers made from the other solvents.