Miracle-dz/UniFAR-FTUs huggingface dataset:
Cutaneous Metastases of Pancreatic Carcinoma as a First Clinical Manifestation

Cutaneous metastases from pancreatic adenocarcinomas are rare lesions. The most common site of cutaneous metastasis is the umbilicus, and this is also known as the 'Sister Mary Joseph' nodule. A 68-year-old Korean male, who was previously healthy and asymptomatic, was seen in the dermatology department for two subcutaneous nodules that he had on his right forearm and his back. Histological examination of the right foreman nodule revealed metastatic adenocarcinoma. Immunohistochemical staining for cytokeratin (CK) 7 and CK 19 were positive, and this strongly suggested the pancreatic duct as being the primary source of the cancer. The abdominal computed tomography findings were compatible with pancreatic cancer. Clinicians should be aware that metastatic cutaneous lesions could be the initial presenting sign for pancreatic cancer. The immunohistochemical staining for CK 7 and 19 may also be helpful in the diagnosis of metastatic pancreatic adenocarcinoma.
Arterial Stiffening Provides Sufficient Explanation for Primary Hypertension

Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirically well-constrained computer models describing the coupled function of the baroreceptor reflex and mechanics of the circulatory system, we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emergence of hypertension. Specifically, the empirically observed chronic changes in pulse pressure with age and the impaired capacity of hypertensive individuals to regulate short-term changes in blood pressure arise as emergent properties of the integrated system. The results are consistent with available experimental data from chemical and surgical manipulation of the cardio-vascular system. In contrast to widely held opinions, the results suggest that primary hypertension can be attributed to a mechanogenic etiology without challenging current conceptions of renal and sympathetic nervous system function.
Glia-related circadian plasticity in the visual system of Diptera

The circadian changes in morphology of the first visual neuropil or lamina of Diptera represent an example of the neuronal plasticity controlled by the circadian clock (circadian plasticity). It is observed in terminals of the compound eye photoreceptor cells, the peripheral oscillators expressing the clock genes. However, it has been found also in their postsynaptic partners, the L1 and L2 monopolar cells, in which the activity of the clock genes have not yet been detected. The circadian input that the L1 and L2 receive seems to originate not only from the retina photoreceptors and from the circadian pacemaker neurons located in the brain, but also from the glial cells that express the clock genes and thus contain circadian oscillators. This paper summarizes the morphological and biochemical rhythms in glia of the optic lobe, shows how they contribute to circadian plasticity, and discusses how glial clocks may modulate circadian rhythms in the lamina.
On a nonlinear integrable difference equation on the square

We present a nonlinear partial dierence equation defined on a square which is obtained by combining the Miura transformations between the Volterra and the modified Volterra dierential-diere nce equations. This equation is not symmetric with respect to the exchange of the two discrete variables. Its integrability is proved by constructing its Lax pair. equation, Lax pair, Miura transformation, Volterra equation. IIOU‡ˆˇ. As O﷿Â‰aeU‡‚oˇÂI IÂoIÂOIOÂ ﷿‡AIOaeUIOÂ U﷿‡‚IÂIÂ, OO﷿Â‰ÂoÂIIOÂ I‡ Œ‚‡‰﷿‡UÂ, ŒOUO﷿OÂ OOoU˜‡ÂUaeˇ ŒOIAEI﷿O‚‡IÂI O﷿ÂOAE﷿‡AO‚‡IO AU﷿s IÂE‰U ‰UUÂ﷿ÂI‡o¸IO-﷿‡AIOaeUIsI U﷿‡‚IÂIÂI ´Oo¸UÂ﷿﷿s ÂaO IO‰UŒ‡ˆÂO. ›UO U﷿‡‚- IÂIÂ IÂ ˇ‚oˇÂUaeˇ aeIIÂU﷿˜IsI OUIOaeUÂo¸IO OÂ﷿ÂaeU‡IO‚Œ ‰‚Ui ‰aeŒ﷿ÂUIsi OÂ﷿Â- IÂIIsi. ¯aO IUÂa﷿﷿UÂIOaeU¸ ‰OŒ‡As‚‡ÂUaeˇ OOaeU﷿OÂIÂI O‡﷿s ¸‡Œae‡. ˚o˛˜Â‚sÂ aeoO‚‡: IÂoIÂOIOÂ IUÂa﷿﷿UÂIOÂ ﷿‡AIOaeUIOÂ U﷿‡‚IÂIÂ, O‡﷿‡ ¸‡Œae‡, O﷿Â- OAE﷿‡AO‚‡IÂ AU﷿s, U﷿‡‚IÂIÂ ´Oo¸UÂ﷿﷿s. The uncovery of new nonlinear integrable completely discrete equations is always a very challenging problem as, by proper continuous limits, many other results on dierential-diere nce and partial dierential equations can be obtained. In the case of dierential equations by now a lot is known starting from the pioneering works by Gardner, Green, Kruskal and Miura. A summary of these results is already of public domain and presented for example in the Encyclopedia of Mathematical Physics (5) or in the Encyclopedia of Nonlinear Science (6). Among those results let us mention the classification scheme of nonlinear integrable partial dierential
Identification of Host-Plant Volatiles and Characterization of Two Novel General Odorant-Binding Proteins from the Legume Pod Borer, Maruca vitrata Fabricius (Lepidoptera: Crambidae)

Chemoreception is a key feature in selection of host plant by phytophagous insects, and odorant-binding proteins (OBPs) are involved in chemical communication of both insects and vertebrates. The legume pod borer, Maruca vitrata Fabricius (Lepidoptera: Crambidae) is one of the key pest species of cowpea and widely distributed throughout tropical and subtropical regions, causing up to 80% of yield loss. In this study, we investigated the electrophysiological responses of female M. vitrata to floral volatiles from V. unguiculata. Seventeen electroantennogram-active compounds were identified from floral volatiles of V. unguiculata by coupled gas chromatography-electroantennography (GC-EAD) and gas chromatography-mass spectrometry (GC-MS). Then, we cloned two novel full-length GOBP genes (MvitGOBP1 and MvitGOBP2) from the antennae of M. vitrata using reverse transcription PCR. Protein sequence analysis indicated that they shared high sequence similarity with other Pyralididae insect GOBPs and had the typical six-cysteine signature. Real-time PCR analysis indicated that MvitGOBP1-2 mRNA was highly expressed in the antennae of female adult with several thousands-fold difference compare to other tissue. Next, the recombinant MvitGOBP1-2 was expressed in Escherichia coli and purified using Ni ion affinity chromatography. Fluorescence binding assays demonstrated that MvitGOBP1-2 had different binding affinities with 17 volatile odorant molecules including butanoic acid butyl ester, limonene, 4-ethylpropiophenone, 1H-indol-4-ol, butanoic acid octyl ester and 2-methyl-3-phenylpropanal. In the field trapping experiment, these six floral volatiles could effectively attract female moths and showed significant difference compared with the blank lure. These results suggested that MvitGOBPs and the seventeen floral volatiles are likely to function in the olfactory behavior response of female moths, which may have played crucial roles in the selection of oviposition sites. The six compounds that we have identified from the volatiles of V. unguiculata may provide useful information for exploring efficiency monitoring and integrated pest management strategies of this legume pod borer in the field.
Common Knowledge and Equilibria Switching ∗

We derive necessary and sufficient conditions in order for rational actors to coordinate on different equilibria in different states of the world. These conditions help us identify what kind of information structures allow for a specific type of sunspot-like equilibrium. This specific type of equilibrium sheds light on the role of common knowledge in explaining puzzling social behaviors, like pursuing or avoiding eye contact, or using innuendos. Our model can also be used to address economic phenomena such as bank-runs. ∗We are indebted to Ehud Kalai for his continuous guidance at every stage of this work. We are grateful to Aviad Heifetz, Mehmet Ekmekci, Emir Kamenica, Balasz Szentes and Asher Wolinsky for their encouragement and helpful comments. All remaining errors are ours. †Department of Managerial Economics and Decision Sciences, Kellogg School of Management, Northwestern University. ‡The Rady School of Management and Computer Science and Engineering, University of California, San Diego.
Potential and limitations of RADARSAT SAR data for wet snow monitoring

Based on Canadian Satellite (RADARSAT) synthetic aperture radar (SAR) images and simulations from a radar-backscattering model, the authors determined that conventional wet snow-mapping algorithms should perform optimally for a snowpack with a liquid-water content /spl ges/3%, at low incidence angle (/spl theta/=20-30/spl deg/) and for a rather smooth surface (rms height /spl les/2.1 mm).
Synthesis of pseudo Kronecker lattice diagrams

The design process of digital circuits is often carried out in individual steps, like logic minimization, mapping and routing. This leads to quality loss, e.g. in cases where highly optimized netlists fit badly onto the target architecture. Lattice diagrams have been proposed as one possible solution. They offer a regular two dimensional structure, thus overcoming the routing problem. However elegant, presented methods have only been shown to find practical lattice representations for small functions. We present heuristic synthesis methods for Pseudo-Symmetric Pseudo Kronecker Decision Diagrams (PSP-KDDs) applicable to incompletely specified multiple output functions. The lattice structure maps directly to both ASICs and fine grain FPGAs. Our method (combining logic minimization, mapping and routing) seeks to minimize area and delay by heuristic methods. Experimental results on a set of MCNC benchmarks show superior quality to previous methods and in many cases even optimal depth results for unfolded lattices.
Sparse Code Shrinkage: Denoising of Nongaussian Data by Maximum Likelihood Estimation

Sparse coding is a method for finding a representation of data in which each of the components of the representation is only rarely significantly active. Such a representation is closely related to redundancy reduction and independent component analysis, and has some neurophysiological plausibility. In this article, we show how sparse coding can be used for denoising. Using maximum likelihood estimation of nongaussian variables corrupted by gaussian noise, we show how to apply a soft-thresholding (shrinkage) operator on the components of sparse coding so as to reduce noise. Our method is closely related to the method of wavelet shrinkage, but it has the important benefit over wavelet methods that the representation is determined solely by the statistical properties of the data. The wavelet representation, on the other hand, relies heavily on certain mathematical properties (like self-similarity) that may be only weakly related to the properties of natural data.
BioSpaun: A large-scale behaving brain model with complex neurons

We describe a large-scale functional brain model that includes detailed, conductance-based, compartmental models of individual neurons. We call the model BioSpaun, to indicate the increased biological plausibility of these neurons, and because it is a direct extension of the Spaun model \cite{Eliasmith2012b}. We demonstrate that including these detailed compartmental models does not adversely affect performance across a variety of tasks, including digit recognition, serial working memory, and counting. We then explore the effects of applying TTX, a sodium channel blocking drug, to the model. We characterize the behavioral changes that result from this molecular level intervention. We believe this is the first demonstration of a large-scale brain model that clearly links low-level molecular interventions and high-level behavior.
Branch prediction and the performance of interpreters — Don't trust folklore

Interpreters have been used in many contexts. They provide portability and ease of development at the expense of performance. The literature of the past decade covers analysis of why interpreters are slow, and many software techniques to improve them. A large proportion of these works focuses on the dispatch loop, and in particular on the implementation of the switch statement: typically an indirect branch instruction. Folklore attributes a significant penalty to this branch, due to its high misprediction rate. We revisit this assumption, considering state-of-the-art branch predictors and the three most recent Intel processor generations on current interpreters. Using both hardware counters on Has well, the latest Intel processor generation, and simulation of the IT-TAGE, we show that the accuracy of indirect branch prediction is no longer critical for interpreters. We further compare the characteristics of these interpreters and analyze why the indirect branch is less important than before.
Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining.

Skeletal muscle primarily relies on carbohydrate (CHO) for energy provision during high-intensity exercise. We hypothesized that sprint interval training (SIT), or repeated sessions of high-intensity exercise, would induce rapid changes in transport proteins associated with CHO metabolism, whereas changes in skeletal muscle fatty acid transporters would occur more slowly. Eight active men (22 +/- 1 yr; peak oxygen uptake = 50 +/- 2 ml.kg(-1). min(-1)) performed 4-6 x 30 s all-out cycling efforts with 4-min recovery, 3 days/wk for 6 wk. Needle muscle biopsy samples (vastus lateralis) were obtained before training (Pre), after 1 and 6 wk of SIT, and after 1 and 6 wk of detraining. Muscle oxidative capacity, as reflected by the protein content of cytochrome c oxidase subunit 4 (COX4), increased by approximately 35% after 1 wk of SIT and remained higher compared with Pre, even after 6 wk of detraining (P < 0.05). Muscle GLUT4 content increased after 1 wk of SIT and remained approximately 20% higher compared with baseline during detraining (P < 0.05). The monocarboxylate tranporter (MCT) 4 was higher after 1 and 6 wk of SIT compared with Pre, whereas MCT1 increased after 6 wk of training and remained higher after 1 wk of detraining (P < 0.05). There was no effect of training or detraining on the muscle content of fatty acid translocase (FAT/CD36) or plasma membrane associated fatty acid binding protein (FABPpm) (P > 0.05). We conclude that short-term SIT induces rapid increases in skeletal muscle oxidative capacity but has divergent effects on proteins associated with glucose, lactate, and fatty acid transport.
How to Make the Team: Social Networks vs. Demography as Criteria for Designing Effective Teams

We compare two alternative approaches for evaluating the potential of a work group or team: one that focuses on team members' demographic characteristics and one that focuses on the members' social networks. Given that people's network contacts often share their demographic attributes (i.e., the network is homophilous), the two approaches seem equivalent and the first seems preferable because it is easier to implement. In this paper, we demonstrate several important limits to this rationale. First, we argue and show, in an analysis of 1,518 project teams in a contract research and development firm, that even when internal organizational networks are significantly homophilous with respect to demographic variables, the very logic of the causal structure that underlies theories of demographic diversity carries ambiguous performance implications. This ambiguity is due to the fact that demographic diversity has opposing effects on two social network variables—internal density and external range—each of which has a positive effect on a team's performance. We also demonstrate that a focus on demographic criteria is problematic because the demographic makeup of an organization can place inherent limits on a manager's ability to shape the demographic composition of a team. The ambiguous performance implications and the inherent limits placed on a manager's ability to manage a team's demography reduce the likelihood that a manager's interventions will be successful. The performance implications of managing a team's social capital, however, are clear.
Full Spectrum Analytical Channel Design with the Capacity/Supply Ratio (CSR)

Analytical channel design tools have not advanced appreciably in the last decades, and continue to produce designs based upon a single representative discharge that may not lead to overall sediment continuity. It is beneficial for designers to know when a simplified design may be problematic and to efficiently produce alternative designs that approximate sediment balance over the entire flow regime. The Capacity/Supply Ratio (CSR) approach—an extension of the Copeland method of analytical channel design for sand channels—balances the sediment transport capacity of a design reach with the sediment supply of a stable upstream reach over the entire flow duration curve (FDC) rather than just a single discharge. Although CSR has a stronger physical basis than previous analytical channel design approaches, it has not been adopted in practice because it can be a cumbersome and time-consuming iterative analysis without the use of software. We investigate eighteen sand-bed rivers in a comparison of designs based on the CSR approach and five single-discharge metrics: the effective discharge (Qeff) or discharge that transports the most sediment over time; the 1.5-year recurrence interval discharge (Q1.5); the bankfull discharge (Qbf); and the discharges associated with 50th (Qs50) and 75th (Qs75) percentiles of the cumulative sediment yield curve. To facilitate this analysis, we developed a novel design tool using the Visual Basic for Applications (VBA) programming language in Excel® to produce stable channel slope/width combinations based on the CSR methodology for both sand- and gravel-bed streams. The CSR Stable Channel Design Tool’s (CSR Tool) code structure was based on Copeland’s method in SAM and HEC-RAS (Hydrologic Engineering Center’s River Analysis System) and was tested with a single discharge to verify outputs. The Qs50 and Qs75 single-discharge designs match the CSR output most closely, followed by the Qbf, Qeff, and Q1.5. The Qeff proved to be the most inconsistent design metric because it can be highly dependent on the binning procedure used in the effectiveness analysis. Furthermore, we found that the more rigorous physical basis of the CSR analysis is potentially most important in designing “labile” channels with highly erodible substrate, high perennial flow “flashiness”, low width-to-depth ratio, and high incoming sediment load. The CSR Tool provides a resource for river restoration practitioners to efficiently utilize design techniques that can promote sediment balance in dynamic fluvial systems.
Controversies in the Management of Open Fractures

Open fractures are a common problem encountered by orthopaedic surgeons and comprise a broad spectrum of trauma. Management is guided by principle-based steps aimed at reducing the risk of gas gangrene or suppurative infections, whilst maintaining viability in a favourable soft tissue environment to reduce the risk of delayed or non-union of bone. Aspects of these principles, however, create discussion around several areas of controversy. The specific antimicrobial regimen and its duration are questions that have been evaluated for decades. Like the ever-evolving nature of the bacterial pathogens, the answer to this is dynamic and changing. The “six-hour rule” is a hotly debated topic with fervent perseverance of this dogma despite a gross lack of support from the literature. The most appropriate soft tissue management approach for open fractures – immediate definitive soft tissue closure versus leaving wounds open for delayed closure or definitive management – is also an area of debate. Exploration of these controversies and consideration for the historical context of the supporting literature furthers our understanding of the critical elements.
Gender and competition at a young age

Gender gaps may be observed in a variety of economic and social environments. One of the possible determining factors is that men are more competitive than women and so, when the competitiveness of the environment increases, the performance of men increases relative to that of women. We test this hypothesis in a field study conducted with 9-year old children, running on a track. They first run alone and then in pairs over a short distance with different gender composition of the pairs. The results support the hypothesis that performance in competition varies according to gender. When children ran alone, there was no difference in performance. In competition boys, but not girls, improved their performance. This finding relates to the discussion regarding single sex schools: the outcomes of examinations in a mixed sex school can show a gender gap in favor of boys, even when this gap does not reflect actual abilities. Girls who are as talented as boys will end up performing worse just because they are not as competitive, and will not achieve as high scores in examinations as boys.
The Molecular Chaperone gp96/GRP94 Interacts with Toll-like Receptors and Integrins via Its C-terminal Hydrophobic Domain*

Background: gp96 is a molecular chaperone that binds and chaperones TLRs and integrins. But the structural basis of such is unknown. Results: Mutation of a C-terminal loop structure in gp96 abrogates its ability to bind and chaperone both receptors. Conclusion: We have successfully mapped the client-binding domain of gp96. Significance: This study shall facilitate the development of targeted gp96 inhibitors for treatment of inflammation. The structural basis for molecular chaperones to discern misfolded proteins has long been an enigma. As the endoplasmic reticulum paralogue of the cytosolic HSP90, gp96 (GRP94, HSP90b1) is an essential molecular chaperone for Toll-like receptors (TLRs) and integrins. However, little is known about its client-binding domain (CBD). Herein, we provide genetic and biochemical evidence to definitively demonstrate that a C-terminal loop structure, formed by residues 652–678, is the critical region of CBD for both TLRs and integrins. Deletion of this region affects neither the intrinsic ATPase activity nor the overall conformation of gp96. However, without it, the chaperoning function of gp96 collapses. We also find a critical Met pair (Met658-Met662) for the folding of integrins but not TLRs. Moreover, we find that the TLR binding to gp96 is also dependent on the C-terminal dimerization domain but not the N-terminal ATP-binding pocket of gp96. Our study has unveiled surprisingly the exquisite specificity of gp96 in substrate binding and suggests a manipulation of its CBD as an alternative strategy for targeted therapy of a variety of diseases.
European VLBI network observations of fourteen GHz-peaked-spectrum radio sources at 5 GHz

We present the results of EVN polarization observations of fourteen GHz-Peaked-Spectrum (GPS) radio sources at 5 GHz. These sources were selected from bright GPS source samples and we aimed at finding Compact Symmetric Objects (CSOs). We have obtained full polarization 5 GHz VLBI observations of 14 sources providing information on their source structure and spectral indices. The results show that two core-jet sources 1433−040 and DA193, out of 14 GPS sources, exhibit integrated fractional polarizations of 3.6% and 1.0% respectively. The other 12 sources have no clear detection of pc-scale polarization. The results confirm that the GPS sources generally have very low polarization at 5 GHz. The sources 1133+432, 1824+271 and 2121−014 are confirmed as CSOs. Three new CSOs 0914+114, 1518+046 and 2322−040 (tentative) have been classified on the basis of 5 GHz images and spectral indices. The sources 1333+589, 1751+278 and 2323+790 can be classified either as compact doubles, and then they are likely CSO candidates or core-jet sources; further observations are needed for an appropriate classification; 0554−026, 1433−040 and 1509+054 are core-jet sources. In addition, we estimate that a component in the jet of quasar DA193 has superluminal motion of 3.3 ± 0.6h −1 c in 5.5 years.