Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of heart failure on stroke mortality and recurrence

Objective We aimed to examine the impact of heart failure (HF) on stroke mortality (in-hospital and postdischarge) and recurrence in a national stroke cohort from Thailand. Methods We used a large, insurance-based database including all stroke admissions in the public health sector in Thailand between 2004 and 2015. Logistic and Royston-Parmar regressions were used to quantify the effect of HF on in-hospital and long-term outcomes, respectively. All models were adjusted for age, sex and comorbidities and stratified by stroke type: acute ischaemic stroke (AIS) or intracerebral haemorrhage (ICH). Multistate models were constructed using flexible survival techniques to predict the impact of HF on the disease course of a patient with stroke (baseline-[recurrence]-death). Only first-ever cases of AIS or ICH were included in the multistate analysis. Results 608 890 patients (mean age 64.29±13.72 years, 55.07% men) were hospitalised (370 527 AIS, 173 236 ICH and 65 127 undetermined pathology). There were 398 663 patients with first-ever AIS and ICH. Patients were followed up for a median (95% CI) of 4.47 years (4.45 to 4.49). HF was associated with an increase in postdischarge mortality in AIS (HR [99% CI] 1.69 [1.64 to 1.74]) and ICH (2.59 [2.07 to 3.26]). HF was not associated with AIS recurrence, while ICH recurrence was only significantly increased within the first 3 years after discharge (1.79 [1.18 to 2.73]). Conclusions HF increases the risk of mortality in both AIS and ICH. We are the first to report on high-risk periods of stroke recurrence in patients with HF with ICH. Specific targeted risk reduction strategies may have significant clinical impact for mortality and recurrence in stroke.
Synthesis and Hypolipidaemic Evaluation of a Series of α‐Asarone Analogues Related to Clofibrate in Mice

A series of α‐asarone analogues related to clofibrate, containing an acetic acid group at C‐2 of the aromatic ring, has been prepared as the acids or as the ethyl and methyl esters. The corresponding alcohols were also synthesized by reduction of the ethyl esters. The compounds were examined in hyperlipidaemic male mice to evaluate their ability to modify serum lipoprotein cholesterol, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol and triglycerides after oral administration of 40 and 80 mg kg−1 for 6 days.
Virtual MIMO Channels in Cooperative Multi-hop Wireless Sensor Networks

In this paper we analyze the performance of virtual multiple-input-multiple-output (MIMO) channels for multi-hop transmission in wireless sensor networks. First, we propose a clustered network topology with sensor nodes grouped in collaborative sets attending to proximity. Then, we propose that all nodes belonging to any given cluster cooperatively transmit and receive data from other clusters, exploiting the diversity advantages of cluster-to-cluster virtual MIMO channels. In order to construct the cooperative transmission, we arrange each hop into two consecutive time slots: the intracluster slot, that accounts for data sharing within the cluster, and the intercluster slot for transmission between clusters; and we devise a cooperative reception protocol within the clusters based upon a simplified selection diversity algorithm. Optimum time assignment and power allocation for both slots are derived taking the cluster-to-cluster probability of outage as the metric. Results for one hop networks and for multi-hop networks are obtained, showing substantial diversity gains and energy savings. Furthermore, results show that the performance of the proposed virtual MIMO channels is equal to that of real MIMO channels but for a small SNR loss.
Per-Partum Anaemia and Missed Post-Partum Haemorrhage in Low Resources Settings

Background: Post-partum haemorrhage is the leading cause of maternal death throughout the world, and anaemia is one of its indirect causes. Anaemia during labour increases the risk of PPH and may lead to maternal mortality even after moderate PPH. Undiagnosed PPH and post-partum anaemia increases the risk of late maternal death in the community. The aim of this study was to assess the prevalence of anaemia on admission for labour, the occult early post-partum haemorrhage and the magnitude of post-partum anaemia in a low resource setting. Methods: This was a longitudinal study. We included pregnant women in labour. Haemoglobin concentration was measured on admission (H0), then 24 hours (H24) and 48 (H48) hours later. The post-partum blood loss was estimated by delta haemoglobin, using the criteria of M. Driessen et al. Results: We recruited 245 pregnant women. The mean age was 27.0 ± 6.0 years. The mean hemoglobin concentration was 11.7 ± 1.9 g/dl, the frequency of anaemia was 30.6% and was related to ethnicity (P = 0.042) gestational age (p < 0.001) marital status (p = 0.014) and the inter pregnancy time space (p = 0.001). Twenty-two-point two percent had post-partum haemorrhage among which 40% were undiagnosed. The mean blood loss was 375 ml and post-partum anaemia rate was 44.5%. Conclusion: Anaemia on admission was related to socio-demographic characteristics. The frequencies of anaemia during labour, missed PPH and undiagnosed post-partum anaemia were high. Haemoglobin concentration on admission for labour and after delivery, reliable method to assess PPH should be mandatory, to better identify per and post-partum anemia, and the management of PPH, in low income environments.
University of Glasgow at TREC 2011: Experiments with Terrier in Crowdsourcing, Microblog, and Web Tracks

In TREC 2011, we focus on tackling the new challenges proposed by the pilot Crowdsourcing and Microblog tracks, using our Terrier Information Retrieval Platform. Meanwhile, we continue to build upon our novel xQuAD framework and data-driven ranking approaches within Terrier to achieve effective and efficient ranking for the TREC Web track. In particular, the aim of our Microblog track participation is the development of a learning to rank approach for filtering within a tweet ranking environment, where tweets are ranked in reverse chronological order. In the Crowdsourcing track, we work to achieve a closer integration between the crowdsourcing marketplaces that are used for relevance assessment, and Terrier, which produces the document rankings to be assessed. Moreover, we focus on generating relevance assessments quickly and at a minimal cost. For the Web track, we enhance the data-driven learning support within Terrier by proposing a novel framework for the fast computation of document features for learning to rank.
miRNAs and their putative roles in the development and progression of Parkinson's disease

Small regulatory RNAs, such as miRNAs, are increasingly being recognized not only as regulators of developmental processes but contributors to pathological states. The number of miRNAs determined experimentally to be involved in Parkinson's disease (PD) development and progression is small and includes regulators of pathologic proteins, neurotrophic factors, and xenobiotic metabolizing enzymes. PD gene-association studies have also indicated miRNAs in the pathology. In this review, we present known miRNAs and their validated targets that contribute to PD development and progression. We also incorporate data mining methods to link additional miRNAs with non-experimentally validated targets and propose additional roles of miRNAs in neurodegenerative processes. Furthermore, we present the potential contribution of next-generation-sequencing approaches to elucidate mechanisms and etiology of PD through discovery of novel miRNAs and other non-coding RNA classes.
On the geometrical evolution of the ionized gas in HII galaxies

Aims. In this paper, we investigate the behaviour of the number of Lyman continuum ionizing photons as compared to the actual number of hydrogen recombinations in HII galaxies. Methods. We evaluate the number of ionizing photons from the population synthesis of spectra observed in the visible, extrapolating the spectra to the extreme ultraviolet (EUV), beyond the Lyman limit. We check for possible systematic deviations of the predicted ionizing spectra in the EUV by comparing the ratio of the predicted number of ionizing photons to the number of recombinations, as measured in H β , ${\Delta \log Q\rm (H^0)}$, with the metallicity. We find that, as far as the number of ionizing photons is concerned, no systematic tendency can be detected. The ${\rm H\beta}$ equivalent width can be understood as a nebular age indicator, decreasing with age, although the observed ${\rm H\beta}$ equivalent width can also be affected by the contribution to the continuum by the accumulation of previous, non-ionizing stellar populations. Results. We attribute the increase of ${\Delta \log Q\rm (H^0)}$ with the age of the burst to the fact that more and more ionizing photons escape the nebulae when the nebulae get older, because of their increasing, expansion-induced subfragmentation.
Task delegation using experience-based multi-dimensional trust

Cooperation among autonomous agents involves an inherent degree of uncertainty. Agents determine for themselves when to initiate cooperation or to assist others, when to rescind commitments, and how to conduct cooperative tasks. For example, an agent may delay the execution of a cooperative task, execute it to a reduced quality, or simply fail to complete it. In this paper, we describe how experience-based trust can be used to minimise the risk associated with cooperation. In particular we propose a mechanism, called multi-dimensional trust, which allows agents to model the trustworthiness of others according to various criteria. This trust information is combined with other factors to enable the selection of cooperative partners. Agents' preferences are represented by a set of factor weightings, which allow trust information to be tailored to the current cooperative priorities. We also describe the experimental validation of our proposed approach.
Clinical research of sublingual immunotherapy on refractory atopic dermatitis with dermatophagoides farina drops

Objective: To evaluate the efficacy and safety of the treatment of refractory atopic dermatitis with dust mite allergen vaccine through sublingual immunotherapy. Methods: To adopt the self control research, compare the eczema area and severity index (EASI), percentage of skin damage area (BSA%) and change in pruritus scoring and drug use scoring of 35 patients with dust mite allergen and refractory atopic dermatitis after receiving the treatment with dust mite allergen vaccine and sublingual immunotherapy for 1 year, and observe recurrence. Results: 31 patients insist in completing the course of treatment for 1 year and 4 patients quit. Eczema area and severity index (EASI), percentage of skin damage area (BSA%) and change in pruritus scoring and drug use scoring after treatment obviously reduce (P mean<0.01) compared with those before treatment. The effective rate is 77.41%. Adverse reactions related to treatment do not obviously occur. The recurrence rate is 9.67% after 1-year follow-up. Conclusion: The sublingual allergen immunotherapy is an effective method with good safety to treat refractory atopic dermatitis caused by dust mite.
The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice

Recent clinical studies have revealed the treatment of diabetic patients with sodium glucose co-transporter2 (SGLT2) inhibitors to reduce the incidence of cardiovascular events. Using nicotinamide and streptozotocin (NA/STZ) -treated ApoE KO mice, we investigated the effects of short-term (seven days) treatment with the SGLT2 inhibitor luseogliflozin on mRNA levels related to atherosclerosis in the aorta, as well as examining the long-term (six months) effects on atherosclerosis development. Eight-week-old ApoE KO mice were treated with NA/STZ to induce diabetes mellitus, and then divided into two groups, either untreated, or treated with luseogliflozin. Seven days after the initiation of luseogliflozin administration, atherosclerosis-related mRNA levels in the aorta were compared among four groups; i.e., wild type C57/BL6J, native ApoE KO, and NA/STZ-treated ApoE KO mice, with or without luseogliflozin. Short-term luseogliflozin treatment normalized the expression of inflammation-related genes such as F4/80, TNFα, IL-1β, IL-6, ICAM-1, PECAM-1, MMP2 and MMP9 in the NA/STZ-treated ApoE KO mice, which showed marked elevations as compared with untreated ApoE KO mice. In contrast, lipid metabolism-related genes were generally unaffected by luseogliflozin treatment. Furthermore, after six-month treatment with luseogliflozin, in contrast to the severe and widely distributed atherosclerotic changes in the aortas of NA/STZ-treated ApoE KO mice, luseogliflozin treatment markedly attenuated the progression of atherosclerosis, without affecting serum lipid parameters such as high density lipoprotein, low density lipoprotein and triglyceride levels. Given that luseogliflozin normalized the aortic mRNA levels of inflammation-related, but not lipid-related, genes soon after the initiation of treatment, it is not unreasonable to speculate that the anti-atherosclerotic effect of this SGLT2 inhibitor emerges rapidly, possibly via the prevention of inflammation rather than of hyperlipidemia.
Doxycycline Stabilizes Vulnerable Plaque via Inhibiting Matrix Metalloproteinases and Attenuating Inflammation in Rabbits

Enhanced matrix metalloproteinases (MMPs) activity is implicated in the process of atherosclerotic plaque instability. We hypothesized that doxycycline, a broad MMPs inhibitor, was as effective as simvastatin in reducing the incidence of plaque disruption. Thirty rabbits underwent aortic balloon injury and were fed a high-fat diet for 20 weeks. At the end of week 8, the rabbits were divided into three groups for 12-week treatment: a doxycycline-treated group that received oral doxycycline at a dose of 10 mg/kg/d, a simvastatin-treated group that received oral simvastatin at a dose of 5 mg/kg/d, and a control group that received no treatment. At the end of week 20, pharmacological triggering was performed to induce plaque rupture. Biochemical, ultrasonographic, pathologic, immunohistochemical and mRNA expression studies were performed. The results showed that oral administration of doxycycline resulted in a significant increase in the thickness of the fibrous cap of the aortic plaque whereas there was a substantial reduction of MMPs expression, local and systemic inflammation, and aortic plaque vulnerability. The incidence of plaque rupture with either treatment (0% for both) was significantly lower than that for controls (56.0%, P<0.05). There was no significant difference between doxycycline-treated group and simvastatin-treated group in any serological, ultrasonographic, pathologic, immunohistochemical and mRNA expression measurement except for the serum lipid levels that were higher with doxycycline than with simvastatin treatment. In conclusion, doxycycline at a common antimicrobial dose stabilizes atherosclerotic lesions via inhibiting matrix metalloproteinases and attenuating inflammation in a rabbit model of vulnerable plaque. These effects were similar to a large dose of simvastatin and independent of serum lipid levels.
Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma

Circular RNAs (circRNAs) have been emerged as an indispensable part of endogenous RNA network. However, the expression significance of circRNAs in hepatocellular carcinoma (HCC) is rarely revealed. The aim of this study was to determine the circRNA expression profile in HCC, and to investigate their clinical significances and relevant mechanisms for cancer progression. The global circRNA expression profile in HCC was measured by circRNA microarray. Levels of one representative circRNAs, hsa_circ_0004018, were confirmed by real-time reverse transcription-polymerase chain reaction. The expression levels of hsa_circ_0004018 in HCC were significantly lower compared with para-tumorous tissue (P<0.001). Our data further showed that lower expression of hsa_circ_0004018 was correlated with serum alpha-fetoprotein (AFP) level, tumor diameters, differentiation, Barcelona Clinic Liver Cancer stage and Tumor-node-metastasis stage. More importantly, we detected liver tissues from chronic hepatitis, cirrhosis and HCC patients; and found that hsa_circ_0004018 harbored HCC-stage-specific expression features in diverse chronic liver diseases (P<0.001). The area under receiver operating characteristic curve was up to 0.848 (95% CI=0.803–0.894, P<0.001). The sensitivity and specificity were 0.716 and 0.815, respectively. Finally, hsa_circ_0004018 might be involved in cancer-related pathways via interactions with miRNAs.
A tactile P 300 brain-computer interface

In this study, we investigated a Brain-Computer Interface (BCI) based on EEG responses to vibro-tactile stimuli around the waist. P300 BCIs based on tactile stimuli have the advantage of not taxing the visual or auditory system and of being potentially unnoticeable to other people. A tactile BCI could be especially suitable for patients whose vision or eye movements are impaired. In Experiment 1, we investigated its feasibility and the effect of the number of equally spaced tactors. Whereas a large number of tactors is expected to enhance the P300 amplitude since the target will be less frequent, it could also negatively affect the P300 since it will be diffi cult to identify the target when tactor density increases. Participants were asked to attend to the vibrations of a target tactor, embedded within a stream of distracters. The number of tactors was two, four or six. We demonstrated the feasibility of a tactile P300 BCI. We did not fi nd a difference in SWLDA classifi cation performance between the different numbers of tactors. In a second set of experiments we reduced the stimulus onset asynchrony (SOA) by shortening the onand/or off-time of the tactors. The SOA for an optimum performance as measured in our experiments turned out to be close to conventional SOAs of visual P300 BCIs.
Stem and Root

Mah ate garlic raw, the peels whispering down his trousers acrid petals blooming at their night camps it pinched his nose, punched it like a thief the brothers called him stinkbreath, bulbhead, medicine mouth, green stems and would not sleep face-to-face as they leaned on stumps in the northern Sierra Nevada forests, darkness so pubic-thatch thick that among the trees they felt like minnows thrashing in a dry sock net.
The Human Microbiome and the Missing Heritability Problem

The “missing heritability” problem states that genetic variants in Genome-Wide Association Studies (GWAS) cannot completely explain the heritability of complex traits. Traditionally, the heritability of a phenotype is measured through familial studies using twins, siblings and other close relatives, making assumptions on the genetic similarities between them. When this heritability is compared to the one obtained through GWAS for the same traits, a substantial gap between both measurements arise with genome wide studies reporting significantly smaller values. Several mechanisms for this “missing heritability” have been proposed, such as epigenetics, epistasis, and sequencing depth. However, none of them are able to fully account for this gap in heritability. In this paper we provide evidence that suggests that in order for the phenotypic heritability of human traits to be broadly understood and accounted for, the compositional and functional diversity of the human microbiome must be taken into account. This hypothesis is based on several observations: (A) The composition of the human microbiome is associated with many important traits, including obesity, cancer, and neurological disorders. (B) Our microbiome encodes a second genome with nearly a 100 times more genes than the human genome, and this second genome may act as a rich source of genetic variation and phenotypic plasticity. (C) Human genotypes interact with the composition and structure of our microbiome, but cannot by themselves explain microbial variation. (D) Microbial genetic composition can be strongly influenced by the host's behavior, its environment or by vertical and horizontal transmissions from other hosts. Therefore, genetic similarities assumed in familial studies may cause overestimations of heritability values. We also propose a method that allows the compositional and functional diversity of our microbiome to be incorporated to genome wide association studies.
Joint Performance Analysis of Channel Quality Indicator Feedback Schemes and Frequency-Domain Scheduling for LTE

Frequency-domain scheduling and rate adaptation enable next-generation orthogonal frequency-division multiple access (OFDMA) cellular systems such as Long-Term Evolution (LTE) to achieve significantly higher spectral efficiencies. LTE uses a pragmatic combination of several techniques to reduce the channel-state feedback that is required by a frequency-domain scheduler. In the subband-level feedback and user-selected subband feedback schemes specified in LTE, the user reduces feedback by reporting only the channel quality that is averaged over groups of resource blocks called subbands. This approach leads to an occasional incorrect determination of rate by the scheduler for some resource blocks. In this paper, we develop closed-form expressions for the throughput achieved by the feedback schemes of LTE. The analysis quantifies the joint effects of three critical components on the overall system throughput-scheduler, multiple-antenna mode, and the feedback scheme-and brings out its dependence on system parameters such as the number of resource blocks per subband and the rate adaptation thresholds. The effect of the coarse subband-level frequency granularity of feedback is captured. The analysis provides an independent theoretical reference and a quick system parameter optimization tool to an LTE system designer and theoretically helps in understanding the behavior of OFDMA feedback reduction techniques when operated under practical system constraints.
The neurology of HTLV-1 infection

HTLV-1 is a significant global health problem but remains largely confined to endemic areas and risk groups. However, increasing migration may mean that the virus will be encountered more frequently in areas traditionally thought of as virtually free of HTLV-1. In this review we discuss the epidemiology, transmission, clinical features, diagnosis and treatment of HTLV-1, focussing specifically on the neurological manifestations. We highlight the circumstances in which HTLV-1 should be suspected and outline the current understanding of HTLV-1-associated myelopathy and other neurological presentations.