Miracle-dz/UniFAR-FTUs huggingface dataset:
Prospective Validation of Immunological Infiltrate for Prediction of Response to Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer – A Substudy of the Neoadjuvant GeparQuinto Trial

Introduction We have recently described an increased lymphocytic infiltration rate in breast carcinoma tissue is a significant response predictor for anthracycline/taxane-based neoadjuvant chemotherapy (NACT). The aim of this study was to prospectively validate the tumor-associated lymphocyte infiltrate as predictive marker for response to anthracycline/taxane-based NACT. Patients and Methods The immunological infiltrate was prospectively evaluated in a total of 313 core biopsies from HER2 negative patients of the multicenter PREDICT study, a substudy of the neoadjuvant GeparQuinto study. Intratumoral lymphocytes (iTuLy), stromal lymphocytes (strLy) as well as lymphocyte-predominant breast cancer (LPBC) were evaluated by histopathological assessment. Pathological complete response (pCR) rates were analyzed and compared between the defined subgroups using the exact test of Fisher. Results Patients with lymphocyte-predominant breast cancer (LPBC) had a significantly increased pCR rate of 36.6%, compared to non-LPBC patients (14.3%, p<0.001). LPBC and stromal lymphocytes were significantly independent predictors for pCR in multivariate analysis (LPBC: OR 2.7, p = 0.003, strLy: OR 1.2, p = 0.01). The amount of intratumoral lymphocytes was significantly predictive for pCR in univariate (OR 1.2, p = 0.01) but not in multivariate logistic regression analysis (OR 1.2, p = 0.11). Conclusion Confirming previous investigations of our group, we have prospectively validated in an independent cohort that an increased immunological infiltrate in breast tumor tissue is predictive for response to anthracycline/taxane-based NACT. Patients with LPBC and increased stromal lymphocyte infiltration have significantly increased pCR rates. The lymphocytic infiltrate is a promising additional parameter for histopathological evaluation of breast cancer core biopsies.
Network Structure and Knowledge Transfer: The Effects of Cohesion and Range

This research considers how different features of informal networks affect knowledge transfer. As a complement to previous research that has emphasized the dyadic tie strength component of informal networks, we focus on how network structure influences the knowledge transfer process. We propose that social cohesion around a relationship affects the willingness and motivation of individuals to invest time, energy, and effort in sharing knowledge with others. We further argue that the network range, ties to different knowledge pools, increases a person's ability to convey complex ideas to heterogeneous audiences. We also examine explanations for knowledge transfer based on absorptive capacity, which emphasizes the role of common knowledge, and relational embeddedness, which stresses the importance of tie strength. We investigate the network effect on knowledge transfer using data from a contract R&D firm. The results indicate that both social cohesion and network range ease knowledge transfer, over and above the effect for the strength of the tie between two people. We discuss the implications of these findings for research on effective knowledge transfer, social capital, and information diffusion.
On-wafer measurements of noise temperature

The NIST Noise Project has developed the theoretical formalism and experimental methods for performing accurate noise-temperature measurements on a wafer. This report summarizes the theoretical formulation and describes the design, methods, and results of tests performed to verify our ability to measure on-wafer noise temperature. Several different configurations with known off-wafer noise sources were used to obtain different, known, on-wafer noise temperatures. These were then measured, and the results were compared to predictions. Good agreement was found, with a worst-case disagreement of 2.6%. An uncertainty analysis of the measurements resulted in an estimated standard uncertainty (1/spl sigma/) of 1.1% or less for most values of noise temperature. The tests also confirm our ability to produce known noise temperatures on a wafer, with an uncertainty of about 1%.
Hubungan Antara Stres Terhadap Guru Dengan Prokrastinasi Akademik Pada Siswa SMA Muhammadiyah 2 Yogyakarta

Abstract This research aims to know the relationship the stress on teachers with academic prokrastination in high student of Muhammadiyah 2 yogyakarta. Subjects in this study were 120 students of class XII IPA and IPS. This research using methods quantitative data by using a measuring instrument in form of psychological scale of the stress on teachers and scale academic procrastination. Technique the sample in research is using cluster random sampling and by lottery at random. The data of research in analyzed by used technique correlation product moment of pearson with used the aid program spss 16.0 for windows . The results of this study showed that there is a very significant positive relationship between stress on teachers with academic procrastination in high school students. This is shown by the correlation coefficient (r) positive 0,311 with p = 0,001 (p < 0,01). Categories of subjects showed that the stress level on the teachers included in the category are of 73,3 % and academic procrastination students are included in category are of 66,7 %. Effective contribution of stress on teachers with academic procrastination indicated by the coefficient of the determinant () = 9,7 % which means that there are 9,7 % of teacher stress can enhance the appearance of the academic procrastination while as many as 90,3 % are influenced by other factors not examined. Based on the research result, it can be concluded that there is very significant positive relationship between stress on teachers with students on academic procrastination. This suggests that the higher the stress on teachers then the higher academic procrastination conducted by students, instead the lower stress on teachers then the lower academic procrastination are done by the students. Key word : stress on teachers, academic procrastination
Regulation of Mariner Transposition: The Peculiar Case of Mos1

Background Mariner elements represent the most successful family of autonomous DNA transposons, being present in various plant and animal genomes, including humans. The introduction and co-evolution of mariners within host genomes imply a strict regulation of the transposon activity. Biochemical data accumulated during the past decade have led to a convergent picture of the transposition cycle of mariner elements, suggesting that mariner transposition does not rely on host-specific factors. This model does not account for differences of transposition efficiency in human cells between mariners. We thus wondered whether apparent similarities in transposition cycle could hide differences in the intrinsic parameters that control mariner transposition. Principal Findings We find that Mos1 transposase concentrations in excess to the Mos1 ends prevent the paired-end complex assembly. However, we observe that Mos1 transposition is not impaired by transposase high concentration, dismissing the idea that transposase over production plays an obligatory role in the down-regulation of mariner transposition. Our main finding is that the paired-end complex is formed in a cooperative way, regardless of the transposase concentration. We also show that an element framed by two identical ITRs (Inverted Terminal Repeats) is more efficient in driving transposition than an element framed by two different ITRs (i.e. the natural Mos1 copy), the latter being more sensitive to transposase concentration variations. Finally, we show that the current Mos1 ITRs correspond to the ancestral ones. Conclusions We provide new insights on intrinsic properties supporting the self-regulation of the Mos1 element. These properties (transposase specific activity, aggregation, ITR sequences, transposase concentration/transposon copy number ratio…) could have played a role in the dynamics of host-genomes invasion by Mos1, accounting (at least in part) for the current low copy number of Mos1 within host genomes.
Psychological aspects of auditory disorders : cognitive functioning and psychological state

This thesis presents six studies concerned with the psychological status of people with audiological disorders, particularly tinnitus and hearing loss. Study One (Part I of the thesis) employed a structured interview and the General Health Questionnaire to investigate the emotional status of subjects with a variety of audiological symptoms. Psychological disorder was found to be more prevalent among subjects complaining of vertigo (64%) than among those complaining of tinnitus (45%); the prevalence of psychological disorder among subjects complaining of hearing loss was lower than among tinnitus subjects (27%). A higher prevalence of disturbance was found among subjects with multiple symptoms. A previous history of psychological distress correlated with current ratings of disturbance. Studies Two and Three (Part II) are concerned with the psychology of cochlear implantation. Methodological issues concerning psychological assessment in this context are discussed. Study Two uses Repertory Grid Technique to assess the psychological consequences of using an implant. Eight out of ten subjects reported important changes in psychological well-being related to their use of the device. Study Three identifies a group of subjects applying for an implant while having a non-organic hearing loss. The implications for the use of standardised assessment procedures are discussed. Studies Four, Five and Six (Part III) assess the cognitive functioning of subjects with tinnitus. Tinnitus subjects' performance on neuropsychological tests is compared with that of hearing impaired control subjects. Subjects were also assessed using the Cognitive Failures Questionnaire (CFQ). The emotional status of the subjects was assessed using the Speilberger State-Trait Anxiety Inventory. The Beck Depression Inventory was also used in Study Six. The groups were not distinguished by a number of neuropsychological tests, however it was found, in Studies Four and Five, that Tinnitus subjects' performance on verbal fluency tests was Significantly poorer than the Control subjects, after hearing loss was controlled for. In Study Six it was found that both Tinnitus and Control subjects performed less well than expected on the STROOP test; this was more apparent in the Tinnitus group. The Tinnitus group also obtained higher CFQ scores in Studies Four and Five. Trait anxiety was a feature of the Tinnitus groups. The implications for the cognitive functioning of both tinnitus and hearing impaired subjects are discussed in terms of Baddeley's model of working memory. The importance of these findings for complaint about tinnitus and hearing loss are considered.
Quota Women Are Threatening to Men: Unveiling the (Counter)Stereotypization of Beneficiaries of Affirmative Action Policies

Two studies carried out among Albanian public-sector employees examined the impact of different types of affirmative action policies (AAPs) on (counter)stereotypical perceptions of women in decision-making positions. Study 1 (N = 178) revealed that participants – especially women – perceived women in decision-making positions as more masculine (i.e., agentic) than feminine (i.e., communal). Study 2 (N = 239) showed that different types of AA had different effects on the attribution of gender stereotypes to AAP beneficiaries: Women benefiting from a quota policy were perceived as being more communal than agentic, while those benefiting from weak preferential treatment were perceived as being more agentic than communal. Furthermore, we examined how the belief that AAPs threaten men’s access to decision-making positions influenced the attribution of these traits to AAP beneficiaries. The results showed that men who reported high levels of perceived threat, as compared to men who reported low levels of perceived threat, attributed more communal than agentic traits to the beneficiaries of quotas. These findings suggest that AAPs may have created a backlash against its beneficiaries by emphasizing gender-stereotypical or counterstereotypical traits. Thus, the framing of AAPs, for instance, as a matter of enhancing organizational performance, in the process of policy making and implementation, may be a crucial tool to countering potential backlash.
Cosmological parameters from strong gravitational lensing and stellar dynamics in elliptical galaxies

Context. Observations of the cosmic microwave background, light element abundances, large-scale distribution of galaxies, and distant supernovae are the primary tools for determining the cosmological parameters that define the global structure of the Universe. Aims. Here we illustrate how the combination of observations related to strong gravitational lensing and stellar dynamics in elliptical galaxies offers a simple and promising way to measure the cosmological matter and dark-energy density parameters. Methods. A gravitational lensing estimate of the mass enclosed inside the Einstein circle can be obtained by measuring the Einstein angle, once the critical density of the system is known. A model-dependent dynamical estimate of this mass can also be obtained by measuring the central velocity dispersion of the stellar component. By assuming the well-tested homologous 1/r 2 (isothermal) profile for the total (luminous+dark) density distribution in elliptical galaxies acting as lenses, these two mass measurements can be properly compared. Thus, a relation between the Einstein angle and the central stellar velocity dispersion is derived, and the cosmological matter and the dark-energy density parameters can be estimated from this. Results. We determined the accuracy of the cosmological parameter estimates by means of simulations that include realistic measurement uncertainties on the relevant quantities. Interestingly, the expected constraints on the cosmological parameter plane are complementary to those coming from other observational techniques. Then, we applied the method to the recent data sets of the Sloan Lens ACS (SLACS) and the Lenses Structure and Dynamics (LSD) Surveys, and showed that the concordance value between 0.7 and 0.8 for the dark-energy density parameter is included in our 99% confidence regions. Conclusions. The small number of lenses available to date prevents us from precisely determining the cosmological parameters, but it still proves the feasibility of the method. When applied to samples made of hundreds of lenses that are expected to become available from forthcoming deep and wide surveys, this technique will be an important alternative tool for measuring the geometry of the Universe.
Analysis of Evolved Sensory-Motor Controllers

We present results from the concurrent evolution of visual sensing morphologies and sensory-motor controller-networks for visually guided robots. In this paper we analyse two (of many) networks which result from using incremental evolution with variable-length genotypes. The two networks come from separate populations, evolved using a common(cid:12)tness function. The observable behaviours of the two robots are very similar, and close to the optimalbehaviour. However, the underlying sensing morphologies and sensory-motor controllers are strikingly di(cid:11)erent. This is a case of convergent evolution at the behavioural level, coupled with divergent evolution at the morphological level. The action of the evolved networks is described. We discuss the process of analysing evolved arti(cid:12)cial networks, a process which bears many similarities to analysing biological nervous systems in the (cid:12)eld of neuroethology.
Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

We conducted the present study to determine whether the angiotensin II type I receptor (AT1) gene might be implicated in human essential hypertension by using case-control and linkage studies. The entire coding and 3' untranslated regions of the AT1 receptor gene (2.2 kb) were amplified by polymerase chain reaction and submitted to single-strand conformation polymorphism in 60 hypertensive subjects with a familial susceptibility. We identified five polymorphisms (T573-->C, A1062-->G, A1166-->C, G1517-->T, and A1878-->G). However, no mutations that alter the encoded amino acid sequence were detected. A case-control study performed on white hypertensive (n = 206; blood pressure, 168 +/- 16/103 +/- 9 mm Hg) and normotensive (n = 298; blood pressure, 122 +/- 10/75 +/- 9 mm Hg) subjects using three of five polymorphisms showed a significant increase in allelic frequency of C1166 in hypertensive subjects (0.36 versus 0.28 for normotensive subjects, chi 2 = 6.8, P < .01). Frequencies for the alleles of the other two polymorphisms (T573-->C, A1878-->G) were similar in both groups. We performed a linkage study using the affected sib pair method and a highly polymorphic marker of the AT1 receptor gene. There was no evidence for linkage in 267 sib pairs analyzed from 138 pedigrees. These findings would be compatible with a common variant of the AT1 receptor imparting a small effect on blood pressure; further studies will be needed to address this possibility.
Preservice Preparation and Classroom Practices of Teachers of Students with Emotional/Behavioral Disorders

A survey was conducted to identify and compare the perceptions of teachers of students with emotional and/or behavioral disorders and those of special teacher educators. The sample, 111 teachers and 25 teacher trainers (a) estimated the number of hours teachers spend weekly executing various responsibilities/competencies, (b) rated the importance of those competencies to teacher effectiveness, and (c) judged the adequacy with which teacher preparation programs are equipping teachers to carry out these responsibilities. Results reveal a general consistency between teachers and teacher educators along these three dimensions in relation to six competency areas: assessment, planning, instruction, behavior management, consulting, and administrative skills. Differences between teachers in self-contained and resource rooms, teachers of elementary versus junior/senior high school students, and those with 5 years or less and 6 years or more teaching experience are discussed.
Resolving Ambiguous Entity through Context Knowledge and Fuzzy Approach

—Entity extraction is considered as a fundamental step in many text mining applications such as machine translation, text summarization and text categorization. However, the major challenging issue in extracting the entity from a sentence is the ambiguity problem, namely lexical ambiguity. While a human has a cognitive capability to resolve the meaning easily based on his/her knowledge, it is very difficult for a machine to do so. This paper proposed a new technique for resolving the ambiguity problem through a fuzzy approach and context knowledge. The technique integrates subject and lexical knowledge, the possibility theory, and fuzzy sets into natural language processing. Lexical knowledge was obtained from WordNet, while subject and lexical knowledge have been deployed as context knowledge. Possibility theory and fuzzy sets were applied to select the most possible meaning of an ambiguous entity based on the context. The work was conducted on the noun part-of-speech only. The technique was implemented and tested with 1110 sentences. Precision and recall measurement metrics were used as an evaluation metric. The obtained precision rate is 85.7% and 80.3% for recall. The results indicate that the proposed technique is successful . (Abstract)
Automatic determination of optimal network topologies based on information theory and evolution

Presents a new approach to determine the optimal topology of multilayer perceptrons for a given learning task, based on information theory and evolution. Our method exploits the mutual information of the input-output relation to sort the units into a list with respect to their information content. Embedded in a evolutionary algorithm, a mutation operator is proposed which removes or adds input units from given networks based on their ranking. The power of the approach is demonstrated on several benchmarks. We conclude that using an evolutionary algorithm as a framework in conjunction with intelligent mutation operators is concurrently the most efficient optimization technique with regard to network size and performance as well as scalability.
Arctic Holocene proxy climate database – new approaches to assessing geochronological accuracy and encoding climate variables

Abstract. We present a systematic compilation of previously published Holocene proxy climate records from the Arctic. We identified 170 sites from north of 58° N latitude where proxy time series extend back at least to 6 cal ka (all ages in this article are in calendar years before present – BP), are resolved at submillennial scale (at least one value every 400 ± 200 years) and have age models constrained by at least one age every 3000 years. In addition to conventional metadata for each proxy record (location, proxy type, reference), we include two novel parameters that add functionality to the database. First, "climate interpretation" is a series of fields that logically describe the specific climate variable(s) represented by the proxy record. It encodes the proxy–climate relation reported by authors of the original studies into a structured format to facilitate comparison with climate model outputs. Second, "geochronology accuracy score" (chron score) is a numerical rating that reflects the overall accuracy of 14C-based age models from lake and marine sediments. Chron scores were calculated using the original author-reported 14C ages, which are included in this database. The database contains 320 records (some sites include multiple records) from six regions covering the circumpolar Arctic: Fennoscandia is the most densely sampled region (31% of the records), whereas only five records from the Russian Arctic met the criteria for inclusion. The database contains proxy records from lake sediment (60%), marine sediment (32%), glacier ice (5%), and other sources. Most (61%) reflect temperature (mainly summer warmth) and are primarily based on pollen, chironomid, or diatom assemblages. Many (15%) reflect some aspect of hydroclimate as inferred from changes in stable isotopes, pollen and diatom assemblages, humification index in peat, and changes in equilibrium-line altitude of glaciers. This comprehensive database can be used in future studies to investigate the spatio-temporal pattern of Arctic Holocene climate changes and their causes. The Arctic Holocene data set is available from NOAA Paleoclimatology.