Miracle-dz/UniFAR-FTUs huggingface dataset:
Increasing Returns, Comparative Advantage, and History: The Formation of the Mining City of Antofagasta

Natural resource endowment is a necessary but insufficient condition to explain the formation of a durable mining city. This article focuses on the dynamic and endogenous factors that give rise to increasing returns to scale as a key element in understanding the formation and sustainability of this type of urban agglomeration. It is also necessary to consider historical perspectives to overcome the limitations of location theory and the "new" economic geography. A classification of mining centers is proposed and the mining city of Antofagasta, Chile is analyzed accordingly. The focus is on the period between 1866 and 1878, which saw the consolidation of the path-dependent process that gave rise to one of the leading mining cities in the Americas.
Strong Antibody Responses to Mycobacterium tuberculosis PE-PGRS62 Protein Are Associated with Latent and Active Tuberculosis

ABSTRACT Mycobacterium tuberculosis has a unique family of PE-PGRS proteins with conserved N-terminal domains (PE) containing site-specific proline-glutamine residues and polymorphic GC-rich repetitive sequences (PGRS). Tuberculosis (TB) patients produce antibodies against some such proteins, but it is not clear whether these responses correlate with disease. Clinical groups with different mycobacterium exposure were studied for their seroreactivity to PE-PGRS17 and PE-PGRS62 proteins and their respective PE domains. There were minimal antibody responses against both PE domains and full-length PE-PGRS17, even in patients with active TB. However, patients with active and latent TB showed significantly higher PE-PGRS62-specific immunoglobulin G antibody responses than treated TB patients and mycobacterium-reactive TB contacts without latent infection. Latently infected persons had high anti-PE-PGRS62 responses but low responses to the 38-kDa antigen commonly used for TB serology, while treated TB cases showed the opposite response. Thus, patterns of seroreactivity to PE-PGRS62 correlate with clinical status and are associated with latent TB infection.
Attention and inhibition in children with ASD, ADHD and co-morbid ASD + ADHD: an event-related potential study

Background Substantial overlap has been reported between attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Deficits in executive function (EF) are characteristic of both disorders but these impairments have not been compared directly across pure and co-morbid cases using event-related potentials (ERPs). Method Behavioural parameters and ERPs were recorded during a flankered cued-continuous performance test (CPT-OX) administered to 8–13-year-old boys with ASD (n = 19), ADHD (n = 18), co-morbid ASD + ADHD (n = 29) and typically developing controls (TD; n = 26). Preparatory processing (contingent negative variation, CNV) and attentional orienting (Cue-P3) at cues, response execution at targets (Go-P3), inhibitory processing at non-targets (NoGo-P3) and conflict monitoring between target and non-target trials (Go-N2 v. NoGo-N2) were examined. Results Categorical diagnoses and quantitative trait measures indicated that participants with ADHD (ADHD/ASD + ADHD) made more omission errors and exhibited increased reaction-time (RT) variability and reduced amplitude of the Cue-P3 and NoGo-P3 compared to TD/ASD participants. Participants with ASD (ASD/ ASD + ADHD) demonstrated reduced N2 enhancement from Go to NoGo trials compared to TD/ADHD participants. Participants with ASD-only displayed enhanced CNV amplitude compared to ASD + ADHD and TD participants. Conclusions Children with ADHD show deficits in attentional orienting and inhibitory control whereas children with ASD show abnormalities in conflict monitoring and response preparation. Children with co-morbid ASD + ADHD present as an additive co-occurrence with deficits of both disorders, although non-additive effects are suggested for response preparation. Measuring ERPs that index attention and inhibition is useful in disentangling cognitive markers of ASD and ADHD and elucidating the basis of co-occurring ASD + ADHD to guide clinical assessment.
Empowered to gain a new foothold in life—A study of the meaning of participating in cardiac rehabilitation to patients afflicted by a minor heart attack

This study aimed to investigate what it means to patients afflicted by a minor heart attack to participate in cardiac rehabilitation (CR). CR is well-established internationally to support patients towards moving forward in satisfying, healthy, and well-functioning lives. Studies indicate that patients achieve improvement in quality of life when participating in CR. However, knowledge of how patients are supported during CR is sparse. Moreover, knowledge of what participating in CR means to patients afflicted by a minor heart attack is lacking. In-depth knowledge in this area is crucial in order to understand these patients’ particular gains and needs. In a phenomenological-hermeneutic frame field observations, focus group interviews, and individual interviews were conducted among 11 patients during and after their participation in CR. Field notes and transcribed interviews underwent three-phased interpretation. It was found that patients were supported to gain renewed balance in their lives during CR. Three themes were identified: (1) receiving a helpful but limited caring hand, (2) being supported to find new values in life, and (3) developing responsibility for the remaining time. The patients were carefully guided through a difficult time and supported to continue in healthy everyday lives. They were given hope which enabled them to find themselves a new foothold in life with respect to their own sense of well-being. This guidance and a sense of hopefulness were provided by heart specialists and more seasoned heart patients. In conclusion, patients were empowered to achieve a healthier lifestyle and improve their personal well-being during CR. However, structural barriers in the programme prevented adequate support regarding the patients’ total needs. Knowledge of the benefits of CR emphasizes the significance of the programme and highlights the importance of high inclusion. Efforts should be made to develop more flexible and longer lasting programmes and further involvement of relatives must be considered.
The lung in the antiphospholipid syndrome

Patients with antiphospholipid syndrome (APS) may develop a broad spectrum of pulmonary disease. Pulmonary thromboembolism and pulmonary hypertension are the most common complications, but microvascular pulmonary thrombosis, pulmonary capillaritis, and alveolar haemorrhage have also been reported. Clinicians should seriously consider these types of vascular injury when evaluating patients with APS who present with dyspnoea, fever, and infiltrates on chest radiography.
National Trends in Exposure to and Experiences of Violence on the Internet Among Children

OBJECTIVE: To examine rates of technology-based violent experiences (eg, bullying, harassment, unwanted sexual experiences [USEs] perpetration, and victimization) and exposures (eg, hate sites) from 2006 to 2008 among US children. PATIENTS AND METHODS: One thousand five-hundred eighty-eight youth aged 10 to 15 years were surveyed nationally online in 2006, 2007 (76% follow-up rate), and 2008 (73% follow-up rate). RESULTS: All other things equal, rates of Internet-based violent exposures and experiences were stable. Of exception, harassment perpetration and exposure to violent cartoon sites reduced by 26% and 36% over the 2 year period (P < 0.05), respectively. In contrast, several rates of violent experiences via text messaging increased over time, specifically: harassment victimization (aOR = 1.6, p = 0.001) and perpetration (aOR = 1.4, p = 0.03), and USE victimization (aOR = 1.9, p = 0.02). Increases in bullying victimization were suggested (aOR = 1.5, p = 0.06). Text messaging USE perpetration did not significantly change, however. General technology use (i.e., intensity and frequency of Internet and text messaging) was consistently influential in explaining the odds of almost all violent experiences and exposures both online and via text messaging; as was age for many exposures and experiences online. CONCLUSIONS: Ongoing surveillance of text-messaging–based experiences is needed to understand trends as population usage rates begin to stabilize. General technology use is a predictive factor for almost all technology-based violent experiences and exposures. Age is also influential in explaining involvement in Internet-based experiences and exposures. Prevention programs should focus on reducing risk as youth age into later adolescence and to help heavy technology users manage their risk for violence involvement.
Attributions And Emotional Well-Being: Giving Up Farming In Finland

Abstract The structural change in agriculture has contributed to the closing down of a large number of farms in Finland. In this article, we examine how ex-farmers attribute the reasons for quitting farming and whether the causal attributions for quitting farming are related to the emotional painfulness of the event and the current emotional well-being of the exfarmers. Contrary to expectations, self-blaming attributions for giving up farming were not prominent. Instead, the study shows that other kinds of attributions than those with a self-blaming tendency are likely to appear. Giving up farming was mainly attributed to ‘external forces’ and ‘orientation to another career’. The former attribution which blames external factors for the event may have psychologically injurious effects in the same way as the self-blaming attribution, whereas the latter internal, self-enhancing attribution is likely to improve emotional well-being after farming.
Technology Innovation and Diffusion as Sources of Output and Asset Price Fluctuations

We develop a model in which innovations in an economy's growth potential are an important driving force of the business cycle. The framework shares the emphasis of the recent "new shock" literature on revisions of beliefs about the future as a source of fluctuations, but differs by tieing these beliefs to fundamentals of the evolution of the technology frontier. An important feature of the model is that the process of moving to the frontier involves costly technology adoption. In this way, news of improved growth potential has a positive effect on current hours. As we show, the model also has reasonable implications for stock prices. We estimate our model for data post-1984 and show that the innovations shock accounts for nearly a third of the variation in output at business cycle frequencies. The estimated model also accounts reasonably well for the large gyration in stock prices over this period. Finally, the endogenous adoption mechanism plays a significant role in amplifying other shocks.
In Situ AFM Study of Crystal Growth on a Barite (001) Surface in BaSO4 Solutions at 30 °C

The growth behavior and kinetics of the barite (001) surface in supersaturated BaSO4 solutions (supersaturation index (SI) = 1.1–4.1) at 30 °C were investigated using in situ atomic force microscopy (AFM). At the lowest supersaturation, the growth behavior was mainly the advancement of the initial step edges and filling in of the etch pits formed in the water before the BaSO4 solution was injected. For solutions with higher supersaturation, the growth behavior was characterized by the advance of the and [010] half-layer steps with two different advance rates and the formation of growth spirals with a rhombic to bow-shaped form and sector-shaped two-dimensional (2D) nuclei. The advance rates of the initial steps and the two steps of 2D nuclei were proportional to the SI. In contrast, the advance rates of the parallel steps with extremely short step spacing on growth spirals were proportional to SI2, indicating that the lateral growth rates of growth spirals were directly proportional to the step separations. This dependence of the advance rate of every step on the growth spirals on the step separations predicts that the growth rates along the [001] direction of the growth spirals were proportional to SI2 for lower supersaturations and to SI for higher supersaturations. The nucleation and growth rates of the 2D nuclei increased sharply for higher supersaturations using exponential functions. Using these kinetic equations, we predicted a critical supersaturation (SI ≈ 4.3) at which the main growth mechanism of the (001) face would change from a spiral growth to a 2D nucleation growth mechanism: therefore, the morphology of bulk crystals would change.
Promoting Forgiveness: A Comparison of Two Brief Psychoeducational Group Interventions With a Waiting‐List Control

The authors studied the effects of 2 brief psychoeducational group interventions on participants' forgiveness for an offender and compared them with a waiting-list control. The Self-Enhancement group justified forgiveness because of its physical and psychological benefits to the forgiver. The Interpersonal group justified forgiveness because of its utility in restoring interpersonal relationships. Both groups led to decreased feelings of revenge, increased positive feelings toward the offender, and greater reports of conciliatory behavior. The Self-Enhancement group also increased affirming attributions toward the offender, decreased feelings of revenge, and increased conciliatory behavior more effectively than did the Interpersonal group.
Random Regression Models Using Legendre Polynomials to Estimate Genetic Parameters for Test-day Milk Protein Yields in Iranian Holstein Dairy Cattle

The objective of this study was to estimate the genetic parameters of milk protein yields in Iranian Holstein dairy cattle. A total of 1,112,082 test-day milk protein yield records of 167,269 first lactation Holstein cows, calved from 1990 to 2010, were analyzed. Estimates of the variance components, heritability, and genetic correlations for milk protein yields were obtained using a random regression test-day model. Milking times, herd, age of recording, year, and month of recording were included as fixed effects in the model. Additive genetic and permanent environmental random effects for the lactation curve were taken into account by applying orthogonal Legendre polynomials of the fourth order in the model. The lowest and highest additive genetic variances were estimated at the beginning and end of lactation, respectively. Permanent environmental variance was higher at both extremes. Residual variance was lowest at the middle of the lactation and contrarily, heritability increased during this period. Maximum heritability was found during the 12th lactation stage (0.213±0.007). Genetic, permanent, and phenotypic correlations among test-days decreased as the interval between consecutive test-days increased. A relatively large data set was used in this study; therefore, the estimated (co)variance components for random regression coefficients could be used for national genetic evaluation of dairy cattle in Iran.
Universal properties of mirror mode turbulence in the Earth's magnetosheath

We use more than 7 years of Time History of Events and Macroscale Interactions during Substorms observations to quantify the non‐Gaussian properties associated with mirror mode turbulence in the Earth's magnetosheath. We find that non‐Gaussian statistics of mirror modes lead to the parabolic collapse of kurtosis as the square of the skewness (K = aS2+B with a ∼ 1.3 and b ∼− 1). The parabolic scaling is a global constraint for the magnetosheath and is dictated by kinetic processes. This parabolic scaling is qualitatively independent of the distance to the magnetopause or bow shock, which implies that, even though the bow shock is driving the mirror mode instability, the dynamical evolution of mirror structures is independent of the source region and due to local processes. The parabolic relationship and coefficients between kurtosis and skewness for mirror modes in the Earth's magnetosheath are also similar to those found in a wide range of geophysical and laboratory turbulent environments, providing further evidence that turbulent systems dominated by non‐Gaussian fluctuations hold universal statistical properties.
Determinantes do valor percebido e da intenção de retorno no turismo receptor brasileiro

This study aims to measure the influence of Brazilian tourism product’s characteristics on the inbound tourist’s perceived value and the intention to return. An empirical study was carried out using a large database contents on international tourism behavior. The logit binomial model was used for estimation. As a result it was found that some of the most relevant characteristics of Brazilian tourism product are hospitality, accommodation, nightlife, public safety and tour guides. Among the least significant aspects are public transport, highways, communication system and tourist signage.
Efficient and Scalable Motif Discovery using Graph-based Search

Identification of short repeated patterns (motifs) in genomic sequences is the key to many problems in bioinformatics. The promoter regions of genes are an important target of search for such motifs (transcription factor binding sites). We present a new algorithm, Mortice, for detecting potential binding sites which are present in a given set of genomic sequences. An informed search is performed by organizing the input patterns and their variants in a graph. Such a strategy efficiently leads to the desired solutions. The background is modeled as a Markov process and a composite score function is used. We demonstrate the performance of our algorithm by testing it on real-life data sets from yeast and human promoter sequences. We compared the performance with several popular algorithms and found that other algorithms work well with lower organisms like yeast but only a couple of them work well with human data. We show that our algorithm scales linearly with the size of input dataset. We compare the computational efficiency of our algorithm with other algorithms and show that it performs faster for different datasets and motif sizes
Comparison study on the speed of convergence in distribution of sample generalized variance and sample vector variance

The stability of covariance structure is a major issue in multivariate statistical process control. We learn from the literature, there are many statistical tests that have been developed to test that stability. In this paper we focus on the generalized variance test and vector variance test and we compare their convergence performance to normality based on simulation study.
The Uses of Disorder: Personal Identity and City Life

An American social critic sets out to show how the excessively ordered community freezes adults - young idealists as well as their security-conscious parents - into rigid attitudes that stifle personal growth. He argues that the accepted ideal of order generates patterns of behaviour among the urban middle classes that are stultifying, narrow and violence-prone. He also proposes a functioning city that can incorporate anarchy, diversity and creative disorder to bring into being adults who can openly respond to and deal with the challenges of life.
Coping as a mediator between personality and stress outcomes: a longitudinal study with cataract surgery patients

Personality and coping were specified as predictors of emotional outcomes of a mildly stressful medical procedure. Situation‐specific coping was examined in contrast to dispositional coping, and it was tested whether one or the other would mediate the relationship between higher‐order personality factors and stress outcomes. Cataract patients (N=110) participated at four measurement points in time during a six‐week period surrounding their scheduled surgery. Dispositional coping did not mediate the personality–outcome relationship. In contrast, situation‐specific coping acquired a mediator status between personality and adaptational criteria and accounted for independent outcome variance once personality traits were included as predictors in the models. Thus, the data suggest that whether or not coping mediates between personality factors and affective outcomes may be related to the methodological approaches of its operationalization. Copyright © 2005 John Wiley & Sons, Ltd.
Microdysgenesis in mesial temporal lobe epilepsy: A clinicopathological study

The interrelationship of mesial temporal lobe epilepsy (MTLE), hippocampal sclerosis, and febrile convulsions still remains an enigma. Additional microscopical cortical dysplasia or microdysgenesis has been suggested as pre‐existent susceptibility factor rendering the affected brain vulnerable to the development of MTLE after initial precipitating injuries such as febrile convulsions. Twenty‐four MTLE cases with histopathologically definite hippocampal sclerosis were examined for clearly defined features of microdysgenesis and further signs of neocortical dysplasia. Although unequivocal signs of dysplasia were absent, 29.2% of cases showed cortical neuronal clustering, 25.0% showed perivascular clustering, and 20.8% showed increased white matter neurons. The features of microdysgenesis studied here were not linked with each other and were not related to initial precipitating injuries, positive family history, or any other clinical parameter. Their suggested fundamental role as dysplastic factor within development of hippocampal sclerosis and MTLE is not confirmed. Ann Neurol 2003;54:501–506
TOWARD A STEWARDSHIP THEORY OF MANAGEMENT

Recent thinking about top management has been influenced by alternative models of man.1 Economic approaches to governance such as agency theory tend to assume some form of homo-economicus, which depict subordinates as individualistic, opportunistic, and self-serving. Alternatively, sociological and psychological approaches to governance such as stewardship theory depict subordinates as collectivists, pro-organizational, and trustworthy. Through this research, we attempt to reconcile the differences between these assumptions by proposing a model based upon the subordinate's psychological attributes and the organization's situational characteristics.
Age- and sex-specific reference limits for creatinine, cystatin C and the estimated glomerular filtration rate

Abstract Background: Early detection of patients with chronic kidney disease is of great importance. This study developed reference limits for serum creatinine and serum cystatin C concentrations and for the estimated glomerular filtration rate (eGFR) in healthy subjects from the general population aged 25–65 years. Methods: This study defined a reference population including 985 subjects from the first follow-up of the Study of Health in Pomerania. Serum creatinine was measured with a modified kinetic Jaffé method. Serum cystatin C was measured with a nephelometric assay. The eGFR was calculated from serum creatinine according to the Cockcroft-Gault (eGFRCG) and the Modification of Diet in Renal Disease (eGFRMDRD) equation, respectively, as well as from serum cystatin C according to the formula by Larsson (eGFRLarsson). Non-parametric quantile regression was used to estimate the reference limits. For serum creatinine and serum cystatin C the 95th percentile and for eGFRCG, eGFRMDRD and eGFRLarsson the 5th percentile were selected as reference limits. All data was weighted to reflect the age- and sex-structure of the German population in 2008. Results: The reference limits for serum creatinine (men: 1.11–1.23 mg/dL; women: 0.93–1.00 mg/dL) and serum cystatin C levels (men: 0.92–1.04 mg/L; women: 0.84–1.02 mg/L) increased with advancing age. The reference limits for eGFR decreased with increasing age (eGFRCG men: 106.0–64.7 mL/min, women 84.4–57.9 mL/min; eGFRMDRD men: 82.5–62.2 mL/min/1.73 m2, women 75.0–58.2 mL/min/1.73 m2; eGFRLarsson men: 85.5–72.9 mL/min, women 94.5–75.7 mL/min). Conclusions: This study presents age- and sex-specific reference limits for five measures of renal function based on quantile regression models.