Miracle-dz/UniFAR-FTUs huggingface dataset:
Helical CT technique for the diagnosis of appendicitis: prospective evaluation of a focused appendix CT examination.

PURPOSE To evaluate a focused, helical computed tomographic (CT) technique for imaging the appendix in patients suspected of having appendicitis. MATERIALS AND METHODS One hundred patients prospectively underwent appendix CT examination, with use of oral and colon contrast media and contiguous, thin-collimation, helical CT imaging of the right lower quadrant. Results were correlated with the results of surgery and pathologic examination from 61 patients or from clinical follow-up in 39 patients. RESULTS CT scans were positive for appendicitis in 59 patients: true-positive in 56 patients on the basis of surgery and pathologic examination, and false-positive in two patients on the basis of clinical follow-up; in the case of the other positive scan, the clinical outcome was indeterminate. CT scans were negative for appendicitis in 41 patients: true-negative in five patients on the basis of surgery and pathologic examination, and true-negative in 36 patients on the basis of clinical follow-up. CT had a sensitivity of 100%, a specificity of 95%, a positive predictive value of 97%, a negative predictive value of 100%, and an accuracy of 98%. The normal appendix was always identified. CT helped establish alternative diagnoses in 33 of the 41 patients (80%) in whom the results of CT were negative for appendicitis. CONCLUSION Appendix CT examination can help diagnose or exclude appendicitis and establish an alternative diagnosis.
Maintained saturation of hippocampal long‐term potentiation does not disrupt acquisition of the eight‐arm radial maze

The present experiment examined the anterograde effect of bilateral saturation of long‐term potentiation (LTP) of the rat perforant path‐granule cell response on acquisition of the eight‐arm radial maze. To ensure maintained saturation, high‐frequency stimulation was applied to the perforant path immediately prior to each trial. LTP did not significantly increase the number of trials required for acquisition of the standard eight‐arm radial maze task. Furthermore, the magnitude of LTP did not correlate with the rate of acquisition. LTP also did not significantly affect the number of either working or reference memory errors during subsequent training with only four of the eight arms baited; both control and LTP rats made significantly more reference memory than working memory errors, with the number of both types of errors decreasing as training progressed. These results indicate that prior saturation of LTP within the perforant path‐dentate granule cell circuit does not affect acquisition of either the reference or working memory components of the radial maze task. The results are discussed in relation to the role of LTP in acquisition of the eight‐arm radial maze.
Utility of hepatitis C viral load monitoring on direct-acting antiviral therapy.

BACKGROUND Hepatitis C virus (HCV) RNA loads serve as predictors of treatment response during interferon-based therapy. We evaluated the predictive ability of HCV RNA levels at end of treatment (EOT) for sustained virologic response (SVR12) during interferon-sparing direct-acting antiviral therapies. METHODS HCV genotype 1-infected, treatment-naive patients were treated with sofosbuvir and ribavirin for 24 weeks (n = 55), sofosbuvir and ledipasvir for 12 weeks (n = 20), sofosbuvir, ledipasvir, and GS-9669 for 6 weeks (n = 20), or sofosbuvir, ledipasvir, and GS-9451 for 6 weeks (n = 19). Measurements of HCV RNA were performed using the Roche COBAS TaqMan HCV test and the Abbott RealTime HCV assay. Positive predictive value (PPV) and negative predictive value (NPV) of HCV RNA less than the lower limit of quantification (<LLOQ) at EOT for SVR12 were calculated. RESULTS All 55 patients treated with sofosbuvir and ribavirin had HCV RNA <LLOQ at EOT by the Roche and Abbott assays, but only 38 achieved SVR12 (PPV, 69%). Among patients treated with sofosbuvir and ledipasvir with or without GS-9669 or GS-9451, 100% (59/59) had HCV RNA <LLOQ by the Roche assay and 1 relapsed (PPV, 98%). By the Abbott assay, 90% (53/59) had HCV RNA <LLOQ, of whom 1 patient relapsed (PPV, 98%). Notably, 6 patients with HCV RNA ≥LLOQ at EOT (range, 14-64 IU/mL) achieved SVR12 (NPV, 0%). Quantifiable HCV RNA (range, 15-57 IU/mL) was measured 2 weeks posttreatment in 4 individuals, and 4 weeks posttreatment in 1 patient (14 IU/mL). CONCLUSIONS Contrary to past experience with interferon-containing treatments, low levels of quantifiable HCV RNA at EOT do not preclude treatment success.
Molecular cloning and characterization of five SmGRAS genes associated with tanshinone biosynthesis in Salvia miltiorrhiza hairy roots

The gibberellin-responsive element binding factor (GRAS) family of proteins plays an important role in the transcriptional regulation of plant development and hormone signaling. To date, there are no reports on GRAS family proteins expressed in Salvia miltiorrhiza. In this study, 28 ESTs that contained the GRAS domain were identified from a S. miltiorrhiza cDNA library. Of these, full-length sequences of five genes were cloned and sequence analysis indicated that all five proteins contain only one GRAS domain and therefore, belong to the GRAS family. The five genes were designated S. miltiorrhiza GRAS1-5 (SmGRAS1-5), which belong to groups I (SmGRAS2 and SmGRAS4), II (SmGRAS3), III (SmGRAS1), and VIII (SmGRAS5) respectively. Additionally, SmGRAS1-5 have different expression patterns in the reed head, stems, leaves, flowers, and roots of S. miltiorrhiza. In this study, the expression of SmGRAS1-5 was sensitive to Gibberellin (GA) stress and that of SmGRAS1, SmGRAS4 and SmGRAS5 was sensitive to Ethephon (Eth) stress respectively. Moreover, S. miltiorrhiza copalyl diphosphate synthases 1 (SmCPS1) and S. miltiorrhiza kaurene synthase like 1 (SmKSL1), which are two key enzymes gene in the diterpenoid biosynthesis pathway, were also response to GA and Eth stress. In addition, Dihydrotanshinone (DT-I) and Tanshinone I (T-I) content were enhanced by GA and Eth stress, Tanshinone IIA (T-IIA) content was increased by GA stress, and the accumulation of Cryptotanshinone (CT) was insensitive to both GA and Eth stress. Together, these results provide insights into functional conservation and diversification of SmGRASs and are useful information for further elucidating SmGRAS functions.
UK Inflation: Persistence, Seasonality and Monetary Policy

In the light of the changes to UK monetary policy since the early 1980s, we study the existence and nature of changes in the properties of retail price inflation over this period. A feature of our analysis is the attention paid to the marked seasonal pattern of monthly UK inflation. After taking account of seasonality, both univariate and Phillips curve models provide strong evidence of changes in the level and persistence of inflation around the end of 1992, at the time of the introduction of inflation targeting. Indeed, all models point to the effective disappearance of inflation persistence after this date, implying that constant-parameter models estimated using both pre- and post-inflation targeting data periods should be treated with considerable caution.
The SRC Panel Data and Mass Political Attitudes

One of the richest data sources for the study of public opinion is the Survey Research Center's panel study conducted in the late 1950s. Because the SRC interviewed its national panel of Americans three times over a four-year period, the SRC panel data allows the analysis of changes in survey responses over time. The most remarkable discovery from the SRC panel was that panelists changed their reported opinions on policy issues with considerable frequency when asked the same policy questions in different years. Moreover, the amount of observed change in the individual responses varied little with the time interval between responses. That is, the correlations between responses to the same issue item in 1956 and 1958 or in 1958 and 1960 (two years apart) were almost as low as the correlations to the same issue item in 1956 and 1960 (four years apart).
A co‐evolutionary perspective in medical technology: Clinical innovation systems in Europe and in Japan

Summary We aim to study the innovation process in medical technology from an evolutionary perspective. By considering a case of medical imaging technology in Europe and in Japan for over a decade, our empirical investigation shows that medical organizations clinically evaluate technological alternatives, from which emerge clinical innovations not captured in patents and licenses and more importantly diffused among a larger community of practice, beyond geographic boundaries. These findings direct our attention to propose a model that links technological change and lead users within a microstate innovation system with respect to clinical advances for patients. This model uses a dynamic and interpretative approach that allows variation and selection within and among heterogeneous agents for technological change. In turn, the clinical innovation system provides us with insights into how firms potentially benefit from these localized interactions through a transnational collaborative and collective learning process. This captures the unique and distinct knowledge accumulated by lead users for novel solutions, which is beyond sole product development.
INTEGRATING CORPORATE SOCIAL POLICY INTO STRATEGIC MANAGEMENT

The 1960s saw the birth of corporate social responsibility. In the 1970s, companies focused on the management of social responsiveness. In the 1980s, corporations are grappling with the issue of making social responsibility a part of overall strategic management. The authors examine some of the ramifications of the search for a new definition of social responsibility.
Modelling and trading the EUR/USD exchange rate at the ECB fixing

The motivation for this paper is to investigate the use of alternative novel neural network (NN) architectures when applied to the task of forecasting and trading the euro/dollar (EUR/USD) exchange rate, using the European Central Bank (ECB) fixing series with only auto-regressive terms as inputs. This is done by benchmarking four different NN designs representing a higher-order neural network (HONN), a Psi Sigma Network and a recurrent neural network with the classic multilayer perception (MLP) and some traditional techniques, either statistical such as an auto-regressive moving average model, or technical such as a moving average convergence/divergence model, plus a naïve strategy. More specifically, the trading performance of all models is investigated in a forecast and trading simulation on the EUR/USD ECB fixing time series over the period 1999–2007 using the last one and half years for out-of-sample testing, an original feature of this paper. We use the EUR/USD daily fixing by the ECB as many financial institutions are ready to trade at this level and it is therefore possible to leave orders with a bank for business to be transacted on that basis. As it turns out, the MLP does remarkably well and outperforms all other models in a simple trading simulation exercise. However, when more sophisticated trading strategies using confirmation filters and leverage are applied, the HONN network produces better results and outperforms all other NN and traditional statistical models in terms of annualized return.
Semiparametric estimation of asset pricing kernel

This article empirically studies the pricing kernel implicit in option prices. Based on the cross-sectional fits alone, no significant difference can be detected between models with different factor dynamics. A cubic pricing kernel provides almost perfect fits in the sample. Nonlinearity in the pricing kernel is crucial for in-sample performance. Both excess kurtosis and skewness are very important. The claim-based market line sharply distinguishes various estimates of the pricing kernel and tracks the market sentiment. However, a well-specified factor dynamics model improves the out-of-sample pricing performance. With a well-specified factor dynamics model, the linear pricing kernel beats the other competitors at a 2-week horizon.
Eyedrop‐Induced Allergy: Clinical Evaluation and Diagnostic Protocol

Abstract Background. In the last few years, adverse reactions to mydriatic eyedrops have been investigated. However, is not still available a standardized protocol, capable of identify the pathogenetic mechanism. In the light of these findings we have evaluated the reliability of a protocol with well established concentration of specific allergens. Methods. The diagnostic method includes the application of patch test series Gruppo Italiano Ricerca Dermatiti da Contatto e Ambientali (GIRDCA), medicaments, corticosteroids, local anesthetics, main eyedrops' excipients, pure active principles and extemporaneous preparations with mydriatic eyewashes. At the same time, skin prick test with a solution of atropine sulfate at 1‰ and an intradermal test with injection of atropine at 0.01‰ were carried out. Results. After patch tests were removed, we detected seven positiveness to the phenylephrine, two to the benzalkonium chloride, one to thiomersal, one to the ethylendiamine and one to the atropine sulfate 1‰. With intradermal tests we obtained three positiveness in patients who reported adverse reactions to atropine. Conclusions. Our results show that phenylephrine is frequently responsible for allergic conjunctivitis (53.8%). In the case of atropine, even though the limited number of patients suggests to perform more extensive studies, it emerges that our diagnostic protocol is safe and might be able to screen allergic reactions in the field of ophthalmopathies.
Nocodazole Inhibits Signal Transduction by the T Cell Antigen Receptor*

The potential role of the cytoskeleton in signaling via the T cell antigen receptor (TCR) was investigated using pharmacological agents. In Jurkat T cells, disruption of the actin-based cytoskeleton with cytochalasin D or disruption of the microtubules with colchicine did not affect TCR induction of proximal signaling events triggered by CD3 mAb. Polymerized actin and tubulin, therefore, were not required for TCR-mediated signal transduction. Nocodazole, however, was found to inhibit dramatically TCR signaling, independently of its ability to depolymerize microtubules. This effect was TCR-specific, because signaling via the human muscarinic acetylcholine receptor 1 in the same cells was unaffected. A mechanism for the inhibition of TCR signaling by nocodazole was suggested byin vitro assays, which revealed that the drug inhibited the kinase activity of LCK and, to a lesser extent, FYN. The kinase activity of ZAP-70 in vitro, however, was unaffected. These results, therefore, suggested that nocodazole prevented initial phosphorylation of the TCR by LCK after stimulation, and as a result, it blocked activation of downstream signaling pathways. Immunofluorescence analyses also revealed that nocodazole and the specific SRC-family kinase inhibitor PP1 delocalized ZAP-70 from its constitutive site at the cell cortex. These effects did not require the SH2 domains of ZAP-70. The localization of ZAP-70 to the cell cortex is, therefore, regulated by the activity of SRC-family kinases, independently of their ability to phosphorylate immunoreceptor tyrosine-based activation motifs of the TCR.
The Impact of the Global Financial Crisis on Mortgage Pricing and Credit Supply

This paper studies the pricing and sales of home mortgages in Australia, focusing on the global financial crisis (GFC). It shows that the crisis significantly changed banks’ pricing behavior and its impact varied across banks, depending on their asset sizes, deposit sources and liquidity profiles. Big banks led in price setting and responded promptly to both upward and downward adjustments of the cash target rate before and during the GFC. Albeit cutting their prices sluggishly after the GFC, they still enjoy greater market power and are expanding faster. Banks with solid deposit support became slower in responding to policy shocks during the GFC and sold more than their counterparts. Interestingly, banks in a better liquidity position tended to be more conservative in pricing during the GFC, i.e. reacting quickly when the cash rate moved up but slowly if it fell, but became more aggressive thereafter.
Trade Openness and Vertical Integration: Evidence from the U.S. Manufacturing Sector

The present article aims to empirically examine a relationship between trade openness and the pattern of vertical integration using the six-digit North American Industry Classification System (NAICS) of U.S. manufacturing data from 2002 to 2006. We use the index of vertical integration made out of inter-plant transfers data by the U.S. Census Bureau, and we consider three proxies of trade openness—import penetration, export shares, and trade penetration. The empirical results substantiate McLaren's (2000) theoretical proposition that trade openness undermines motives for vertical integration.
Increasing returns: historiographic issues and path dependence

Writing a history of the analysis of increasing returns in economics is qualitatively different from the usual cumulative history of knowledge, as exemplified by the history of perfectly competitive analysis. The history of increasing returns is much less continuous. The reason for this irregular history lies, in my view, in the analytic nature of the subject. I concentrate on the recent history of the implications of increasing returns for path dependence in economic development. Foreshadowed by Veblen (1915) the topic was made explicit by Paul David in some theoretical analyses of topics in economic history (1971, 1975) and then by subsequent papers by David and by Brian Arthur in the 1980s. Contemporaneously, Farrell, Katz, Saloner, and Shapiro came to parallel conclusions in a very specific industrial organization context marked by network externalities.
Sustaining the Financial Value of Global CSR: Reconciling Corporate and Stakeholder Interests in a Less Regulated Environment

In this article we examine the association between corporate social responsibility (CSR) and firm value. This line of research is important since firms continue to invest in CSR even though past studies reveal a limited linkage between financial value and CSR. However, the business case for CSR or “doing good while making a profit,” appears to be advancing within the business ethics literature as a preferred conception of CSR. We conjecture that the greater unification and refinement of both profit maximization and stakeholder interests through corporate acts, not statements alone, will sustain the financial value of CSR in a less regulated global business environment. We study the triangle of what companies say, what companies do, and firm financial performance. We analyze Fortune 250 firms and find a positive association between what companies do based on KLD Research and Analytics, Inc. (KLD) ratings, and what companies state about ethics in their CSR statements. We then employ regression analysis and find that companies’ socially responsible acts are positively associated with overall firm value and financial performance. Yet we do not find a statistically significant association between what companies say regarding ethics in their CSR statements and their financial outcomes. These results suggest that firm value and financial performance is associated with what companies do and not what they say. Our results seem to be driven by multinational corporations (MNCs) and not by non‐MNCs. This is possibly because MNCs generally operate in a less regulated global business environment that often necessitates strong ethical corporate leadership to further stakeholder interests. Overall, these results help reconcile corporate and stakeholder objectives since evidence of a link between financial performance and doing good sustains global CSR.
Pharmacokinetic model-driven infusion of fentanyl: assessment of accuracy.

Computer-assisted continuous infusion (CACI) is a pharmacokinetic model-driven infusion device that enables physicians to administer intravenous (iv) drugs in a quantitative fashion, specifying a theoretical blood or plasma concentration. This study evaluated the accuracy of CACI administration of fentanyl using a newly developed CACI device programmed with a well-known set of pharmacokinetic parameters for fentanyl. Patients received diazepam 1 or 2 h before surgery. Anesthesia was induced by a combination of 70% N2O and fentanyl administered by CACI to a predicted concentration of 15-25 ng.ml-1. After neuromuscular blockade and tracheal intubation, the desired plasma fentanyl concentration (setpoint) entered into CACI was 3-6 ng.ml-1, and then the setpoint fentanyl concentration was titrated according to strict criteria of adequate or inadequate anesthesia. Plasma samples for subsequent assay of fentanyl concentration then were taken: at predefined stimuli, when inadequate anesthesia occurred, or 5 min before an anticipated decrease in the fentanyl setpoint. The predictive accuracy of CACI was assessed by calculating for each patient the tenth, 50th, and 90th percentile of the performance error and absolute performance error from each measured and predicted plasma sample pair. Cumulative probability functions for each of these were then plotted. Precision was defined as the dispersion of the tenth to 90th percentile of the median percent performance error for the population and was found to be -31-26%. The median population performance error was -4%, and the median population absolute performance error was 21%. (ABSTRACT TRUNCATED AT 250 WORDS)
Wage reduction of Portuguese civil servants and their attitudes: the psychological contract perspective

This study is based on the psychological contract theoretical model. It provides an empirical test of the antecedents and consequences of psychological contract violation (PCV) that was caused by the wage reduction of Portuguese civil servants. Data were collected from a sample of 212 employees who worked in public organizations across different sectors. These positions entailed different functions and were subject to different levels of wage reduction. A Structural Equation Model was used to analyze the data. The results show that employees' attributions of this psychological contract breach are related to their perception of PCV. Furthermore, our findings also suggest that civil servants have two distinct psychological contracts and that the PCV of the employing organization also depends on the PCV of the public institution. Moreover, the PCV of the public institution was found to be the mechanism that explains the relationship between the meaning attached to wage reduction and the PCV of the employing organization. Finally, our findings confirm that the PCV of the employing organization mediates the relationships between the PCV of the public institution and the commitment and turnover intentions of civil servants. Therefore, such results highlight the usefulness of the psychological contract framework in explaining civil servants' reactions to wage reduction.