Miracle-dz/UniFAR-FTUs huggingface dataset:
Urinary excretion of methylamines in men with varying intake of fish from the Baltic Sea.

Fish contain methylamines, especially trimethylamine N-oxide (TMAO), trimethylamine (TMA), and dimethylamine (DMA). Further, DMA may be formed TMA and TMAO. DMA is a precursor of nitrosodimethylamine (NDMA), which is a potent carcinogen. Levels of DMA, TMA, and TMAO in urine were used as indicators of the dietary exposure and in vivo formation of these amines in 44 men, representing 3 groups with different fish consumption habits. The levels of TMA (median 0.24 mmol/mol creatinine; range 0-2.7) and TMAO (median 38 mmol/mol creatinine; range 8-290) were significantly associated with the weekly intake of fish (r = .47, p = .001, and r = .53, p = .0002, respectively), while no such relation was found for DMA (median 24 mmol/mol creatinine; range 5-46). Further, urinary levels of TMA and TMAO were dependent on recent intake of fish.
The combinatorics of Coxeter categories

We present an alternative construction of Soergel's category of bimodules associated to a reflection faithful representation of a Coxeter system. We show that its objects can be viewed as sheaves on the associated moment graph. We introduce an exact structure and show that Soergel's "special" bimodules are the projective objects. Then we construct the indecomposable projectives by both a global and a local method, discuss a version of the Kazhdan-Lusztig conjecture and prove it for universal Coxeter systems.
Tests of the Relationship Between Children's Temperament and Asthma and of the Reliability and Validity of the Brief Scale of Temperament

Abstract Two studies are reported. One examined the reliability and validity of a brief scale to measure children's temperament; the other tested the relationship of early temperament and the development of asthma. In Study 1, principal caretakers of 46 4- to 7-year-olds, usually the mothers, filled out questionnaires containing the Brief Scale of Temperament (BST) and the Behavioral Style Questionnaire. The caretakers did this twice, about 1 week apart. The first time the children's recent temperament was assessed, and the second time past (> 1 year) temperament was assessed. Internal consistency and correlational analyses revealed substantial reliability and validity for BST assessments of recent and past temperament. Study 2 incorporated the BST in a large-scale survey of 325 families, with parents providing data on their children's asthma and temperament. BST assessments of early (past) temperament were made retrospectively regarding the child's first few years. Comparisons of early temperament revealed no differences between children who developed asthma and those who did not in their overall scores on the BST or for any of the temperament characteristics it measures. In addition, correlational analyses of data for asthmatics showed that early temperament was not related to ratings of the severity of the asthma condition the children developed or the impacts of any of 12 specific asthma triggers, including any involving emotional states, such as stress or worry.
Stimulation-Evoked Ca2+ Signals in Astrocytic Processes at Hippocampal CA3–CA1 Synapses of Adult Mice Are Modulated by Glutamate and ATP

To date, it has been difficult to reveal physiological Ca2+ events occurring within the fine astrocytic processes of mature animals. The objective of the study was to explore whether neuronal activity evokes astrocytic Ca2+ signals at glutamatergic synapses of adult mice. We stimulated the Schaffer collateral/commissural fibers in acute hippocampal slices from adult mice transduced with the genetically encoded Ca2+ indicator GCaMP5E driven by the glial fibrillary acidic protein promoter. Two-photon imaging revealed global stimulation-evoked astrocytic Ca2+ signals with distinct latencies, rise rates, and amplitudes in fine processes and somata. Specifically, the Ca2+ signals in the processes were faster and of higher amplitude than those in the somata. A combination of P2 purinergic and group I/II metabotropic glutamate receptor (mGluR) antagonists reduced the amplitude of the Ca2+ transients by 30–40% in both astrocytic compartments. Blockage of the mGluRs alone only modestly reduced the magnitude of the stimulation-evoked Ca2+ signals in processes and failed to affect the somatic Ca2+ response. Local application of group I or I/II mGluR agonists or adenosine triphosphate (ATP) elicited global astrocytic Ca2+ signals that mimicked the stimulation-evoked astrocytic Ca2+ responses. We conclude that stimulation-evoked Ca2+ signals in astrocytic processes at CA3–CA1 synapses of adult mice (1) differ from those in astrocytic somata and (2) are modulated by glutamate and ATP.
Detection of the Buried Active Galactic Nucleus in NGC 6240 with the Infrared Spectrograph on the Spitzer Space Telescope

We present mid-infrared spectra of the nearby ultraluminous infrared galaxy NGC 6240 taken with the Infrared Spectrograph (IRS) on the Spitzer Space Telescope. The spectrum of NGC 6240 is dominated by strong fine-structure lines, rotational H2 lines, and polycyclic aromatic hydrocarbon (PAH) emission features. The H2 line fluxes suggest molecular gas at a variety of temperatures. A simple two-temperature fit to the S(0) through S(7) lines implies a mass of ~6.7 × 106 M☉ at T ~ 957 K and ~1.6 × 109 M☉ at T ~ 164 K, or about 15% of the total molecular gas mass in this system. Notably, we have detected the [Ne V] 14.3 μm emission line, with a flux of 5 × 10-14 ergs cm-2 s-1, providing the first direct detection of the buried active galactic nucleus (AGN) in the mid-infrared. Modeling of the total spectral energy distribution (SED) from near- to far-infrared wavelengths requires the presence of a hot dust (T ~ 700 K) component, which we also associate with the buried AGN. The small [Ne V]/[Ne II] and [Ne V]/IR flux ratios, the relative fraction of hot dust emission, and the large 6.2 μm PAH equivalent width (EQW), are all consistent with an apparent AGN contribution of only 3%-5% to the bolometric luminosity. However, correcting the measured [Ne V] flux by the extinction implied by the silicate optical depth and our SED fitting suggests an intrinsic fractional AGN contribution to the bolometric luminosity of ~20%-24% in NGC 6240, which lies within the range implied by fits to the hard X-ray spectrum.
Intervening after the loss of a spouse: is it (cost-)effective and for whom?

The association between widowhood and mental health problems, such as depressive symptomatology and anxiety, has been examined extensively. Few studies, however, have explored the prevalence and incidence of mood and anxiety disorders after the loss of the partner. We conducted a systematic review, and searched major bibliographical databases for studies examining mood and anxiety disorders in widowhood. We included all studies examining the prevalence or incidence of mood and anxiety disorders in the widowed, according to diagnostic criteria as assessed with a structured diagnostic interview. Eleven studies were identified, exploring the prevalence and incidence of mood and anxiety disorders in 3,481 widowed individuals and 4,685 non-widowed controls. As expected, the prevalence of major depressive disorder (MDD) and several anxiety disorders were considerably elevated in widowed individuals, especially in the first year after the loss of a spouse. During the first year of bereavement, almost 22 percent of the widowed were diagnosed as having MDD; almost 12 percent met diagnostic criteria for Post Traumatic Stress Disorder; and there were clear indications for elevated risks of Panic Disorder and Generalized Anxiety Disorder. The incidence rate of MDD and several anxiety disorders ranged from 0.08 to 0.50. The relative risk of developing a mood or anxiety disorder ranged from 3.49 to 9.76, in the widowed, compared to control subjects.
NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

Analogues of L-arginine with modifications at the terminal guanidino nitrogen and/or the carboxyl terminus of the molecule have been widely used for their ability to inhibit the production of nitric oxide and are thought to be competitive antagonists of nitric oxide synthase. The present studies were designed to test the possibility that these agents are also muscarinic receptor antagonists. Acetylcholine produced concentration-dependent contraction of endothelium-denuded rabbit coronary artery as well as isolated strips of canine colonic smooth muscle. The arginine analogue NG-nitro L-arginine methyl ester (L-NAME, 100 microM) but not NG-monomethyl L-arginine (L-NMMA, 100 microM) significantly shifted these contractile relations to the right, an effect that was not reversed by addition of 1 mM L-arginine. In radioligand binding studies using the muscarinic radioligand [3H]quinuclidinyl benzilate and tissues known to contain differing contributions of M1, M2, and M3 muscarinic receptors, addition of increasing concentrations of L-NAME resulted in a monophasic competition of binding with affinities (Ki) ranging from 68 microM in endothelium to 317 microM in whole aorta. Addition of the hydrolysis-resistant guanosine 5'-triphosphate analogue GTP gamma S (100 microM) had no effect on L-NAME competition of [3H]quinuclidinyl benzilate binding. Addition of L-NAME in radioligand binding competition studies using the agonist carbachol did not result in an alteration of the receptor's affinity for agonist, confirming the competitive nature of the interaction of L-NAME with the muscarinic receptor. (ABSTRACT TRUNCATED AT 250 WORDS)
Improved techniques of restrained search predictive control for multiphase drives

Predictive control is becoming an alternative to standard vector control or direct torque control in electrical drives due to its fast torque response and design flexibility. In multiphase drives, where the complexity of the modulation techniques and control schemes is higher, the predictive control has proved to be a promising alternative. The main shortcoming of the standard predictive control (SPC) in multiphase drives is the high computational cost caused by the increased number of switching state possibilities. This work proposes a restrained search predictive control (RSPC) where some switching states are discarded by imposing several restrictions. The steady and transient states are explored, also examining the unbalance in the switching frequency of the voltage source inverter (VSI) legs and the effect of allowing submodulation. The advantages of the proposed control are discussed and the viability is confirmed by simulation.
Separate jasmonate-dependent and salicylate-dependent defense-response pathways in Arabidopsis are essential for resistance to distinct microbial pathogens.

The endogenous plant hormones salicylic acid (SA) and jasmonic acid (JA), whose levels increase on pathogen infection, activate separate sets of genes encoding antimicrobial proteins in Arabidopsis thaliana. The pathogen-inducible genes PR-1, PR-2, and PR-5 require SA signaling for activation, whereas the plant defensin gene PDF1.2, along with a PR-3 and PR-4 gene, are induced by pathogens via an SA-independent and JA-dependent pathway. An Arabidopsis mutant, coi1, that is affected in the JA-response pathway shows enhanced susceptibility to infection by the fungal pathogens Alternaria brassicicola and Botrytis cinerea but not to Peronospora parasitica, and vice versa for two Arabidopsis genotypes (npr1 and NahG) with a defect in their SA response. Resistance to P. parasitica was boosted by external application of the SA-mimicking compound 2, 6-dichloroisonicotinic acid [Delaney, T. , et al. (1994) Science 266, 1247-1250] but not by methyl jasmonate (MeJA), whereas treatment with MeJA but not 2,6-dichloroisonicotinic acid elevated resistance to Alternaria brassicicola. The protective effect of MeJA against A. brassicicola was the result of an endogenous defense response activated in planta and not a direct effect of MeJA on the pathogen, as no protection to A. brassicicola was observed in the coi1 mutant treated with MeJA. These data point to the existence of at least two separate hormone-dependent defense pathways in Arabidopsis that contribute to resistance against distinct microbial pathogens.
Decision contamination in the wild: Sequential dependencies in Yelp review ratings

Current judgments are systematically biased by prior judgments. Such biases occur in ways that seem to reflect the cognitive system’s ability to adapt to the statistical regularities within the environment. These cognitive sequential dependencies have been shown to occur under carefully controlled laboratory settings as well as more recent studies designed to determine if such effects occur in real world scenarios. In this study we use these well-known findings to guide our analysis of over 2.2 million business review ratings. We explore how both within-reviewer and within-business (between reviewer) ratings are influenced by previous ratings. Our findings, albeit exploratory, suggest that current ratings are influenced in systematic ways by prior ratings. This work is couched within a broader program that aims to determine the validity of laboratory findings using large naturally occurring behavioral data.
Astrophysics Size Dependence of Solar X-ray Flare Properties

Non-thermal and thermal parameters of 85 solar flares of GOES class B1 to M6 (background subtracted classes A1 to M6) have been compared to each other. The hard X-ray flux has been measured by RHESSI and a spectral fitting provided flux and spectral index of the non-thermal emission, as well as temperature and emission measure of the thermal emission. The soft X-ray flux was taken from GOES measurements. We find a linear correlation in a double logarithmic plot between the non-thermal flux and the spectral index. The higher the acceleration rate of a flare, the harder the non-thermal electron distribution. The relation is similar to the one found by a comparison of the same parameters from several sub-peaks of a single flare. Thus small flares behave like small subpeaks of large flares. Thermal flare properties such as temperature, emission measure and the soft X-ray flux also correlate with peak non-thermal flux. A large non-thermal peak flux entails an enhancement in both thermal parameters. The relation between spectral index and the non-thermal flux is an intrinsic feature of the particle acceleration process, depending on flare size. This property affects the reported frequency distribution of flare energies.
Cdmtcs Research Report Series Randomness, Relativization and Turing Degrees Randomness, Relativization, and Turing Degrees

We compare various notions of algorithmic randomness. First we consider relativized randomness. A set is n-random if it is Martin-Löf random relative to ∅ (n−1). We show that a set is 2-random if and only if there is a constant c such that infinitely many initial segments x of the set are c-incompressible: C(x) ≥ |x| − c. The 'only if' direction was obtained independently by Joseph Miller. This characterization can be extended to the case of time-bounded C-complexity. Next we prove some results on lowness. Among other things, we characterize the 2-random sets as those 1-random sets that are low for Chaitin's Ω. Also, 2-random sets form minimal pairs with 2-generic sets. The r.e. low for Ω sets coincide with the r.e. K-trivial ones. Finally we show that the notions of Martin-Löf randomness, recursive random-ness, and Schnorr randomness can be separated in every high degree while the same notions coincide in every non-high degree. We make some remarks about hyperimmune-free and PA-complete degrees.
The effects of physical activity on functional MRI activation associated with cognitive control in children: a randomized controlled intervention

This study used functional magnetic resonance imaging (fMRI) to examine the influence of a 9-month physical activity program on task-evoked brain activation during childhood. The results demonstrated that 8- to 9-year-old children who participated in 60+ min of physical activity, 5 days per week, for 9 months, showed decreases in fMRI brain activation in the right anterior prefrontal cortex coupled with within-group improvements in performance on a task of attentional and interference control. Children assigned to a wait-list control group did not show changes in brain function. Furthermore, at post-test, children in the physical activity group showed similar anterior frontal brain patterns and incongruent accuracy rates to a group of college-aged young adults. Children in the wait-list control group still differed from the young adults in terms of anterior prefrontal activation and performance at post-test. There were no significant changes in fMRI activation in the anterior cingulate cortex (ACC) for either group. These results suggest that physical activity during childhood may enhance specific elements of prefrontal cortex function involved in cognitive control.
Genome‐wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early‐onset, major depression

In this report, we describe the results of the first genome‐wide linkage survey for genetic loci that influence the development of unipolar Mood Disorders in 81 families identified by individuals with Recurrent, Early‐Onset, Major Depressive Disorder (RE‐MDD). Model‐free linkage analysis was performed using genotypes for 392 highly informative polymorphisms with an average spacing of 9 cM. The highest maximum LOD score observed, 8.19 (genome‐wide adjusted P ≪ 0.0001), occurred for Recurrent Major Depressive Disorder (R‐MDD) at D2S2321 (205 cM), located 121 kb proximal to CREB1. Nineteen chromosomal regions contained linkage peaks that reached genome‐wide statistical significance (genome‐wide adjusted P < 0.05) and ten of these were “highly significant” (adjusted P < 0.001). Six of the 19 linkage peaks were revealed only when the analysis included covariates to control for the effects of sex and linkage to CREB1. Sex‐specific susceptibility loci were common and preferentially affected the vulnerability of women to developing unipolar Mood Disorders. Five loci revealed evidence of interaction with the CREB1 locus in determining susceptibility (epistasis). A systematic candidate gene analysis is presented and potential overlaps of the linkage regions for unipolar Mood Disorders with those reported for other psychiatric disorders are discussed. The findings suggest that genes whose products participate in cellular signaling pathways that converge on CREB, as well as the target genes whose expression they regulate, may also harbor alleles that affect the development of Mood Disorders and related conditions. © 2003 Wiley‐Liss, Inc.
Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin

Hereditary spastic paraplegias, a group of neurodegenerative disorders, can be caused by loss-of-function mutations in the protein spartin. However, the physiological role of spartin remains largely elusive. Here we show that heterologous expression of human or Drosophila spartin extends chronological lifespan of yeast, reducing age-associated ROS production, apoptosis, and necrosis. We demonstrate that spartin localizes to the proximity of mitochondria and physically interacts with proteins related to mitochondrial and respiratory metabolism. Interestingly, Nde1, the mitochondrial external NADH dehydrogenase, and Pda1, the core enzyme of the pyruvate dehydrogenase complex, are required for spartin-mediated cytoprotection. Furthermore, spartin interacts with the glycolysis enhancer phospo-fructo-kinase-2,6 (Pfk26) and is sufficient to complement for PFK26-deficiency at least in early aging. We conclude that mitochondria-related energy metabolism is crucial for spartin’s vital function during aging and uncover a network of specific interactors required for this function.
Event-Triggered Second-Moment Stabilization of Linear Systems Under Packet Drops

This paper deals with the stabilization of linear systems with process noise under packet drops between the sensor and the controller. Our aim is to ensure exponential convergence of the second moment of the plant state to a given bound in finite time. Motivated by considerations about the efficient use of the available resources, we adopt an event-triggering approach to design the transmission policy. In our design, the sensor's decision to transmit or not is based on an online evaluation of whether the control objective may be violated in the future. The resulting event-triggering policy is hence specifically tailored to the control objective. We formally establish that the proposed event-triggering policy meets the desired objective and quantify its efficiency by providing an upper bound on the fraction of expected number of transmissions in an infinite time interval. Simulations for scalar and vector systems illustrate the results.
Air Pollution and Human Sperm Sex Ratio

The present study was designed to address the hypothesis that exposure to specific air pollutants may impact human sperm Y:X chromosome ratio. The study population consisted of 195 men who were attending an infertility clinic for diagnostic purposes and who had normal semen concentration of 15–300 mln/ml (WHO, 2010). Participants represented a subset of men in a multicenter parent study conducted in Poland to evaluate environmental factors and male fertility. Participants were interviewed and provided a semen sample. The Y:X ratio was assessed by fluorescent in situ hybridization (FISH). Air quality data were obtained from the AirBase database. In multivariate analysis the significant reduction was observed in the proportion of Y/X chromosome bearing sperm and exposure to particulate matter >10 μm in aerodynamic diameter PM10 (p = .009) and particulate matter <10 μm in aerodynamic diameter PM2.5 (p = .023). The observed effects of a lower Y:X sperm chromosome ratio among men exposed to air pollution support the evidence that the trend of declining sex ratio in several societies over past decades has been due to exposure to air pollution; however due to limited data on this issue, the obtained results should be confirmed in longitudinal studies.
Familial Aggregation and Heritability of Wuchereria bancrofti Infection.

BACKGROUND The familial recurrence risk of lymphatic filariasis (LF) is unknown. This case study aimed to evaluate the familial susceptibility to infection with Wuchereria bancrofti and to microfilaremia in a village of the Republic of Congo. METHODS The heritability and intrafamilial correlation coefficients were assessed for both W. bancrofti infection and microfilaremia by controlling for individual risk factors, environmental influence, and household effects. RESULTS Pedigree charts were constructed for 829 individuals, including 143 individuals with a diagnosis of W. bancrofti circulating filarial antigens (CFAs) and 44 who also had microfilariae (MF). There was no intrafamilial correlation regarding CFA levels. However, the presence of MF (ρ = 0.45) and microfilarial density (ρ = 0.44) were significantly correlated among parent-offspring pairs. Heritability estimates for CFA positivity and intensity were 0.23 and 0.18, respectively. Heritability estimates were high for microfilarial positivity (h(2) = 0.74) and microfilarial density traits (h(2) = 0.81). CONCLUSIONS Our study suggests that the acquisition of LF is mainly driven by environmental factors and habits and that genetic factors are moderately involved in the regulation of infection. By contrast, genetic factors play a major role in both the presence and intensity of microfilaremia.