Miracle-dz/UniFAR-FTUs huggingface dataset:
Imprints of dark energy on cosmic structure formation – I. Realistic quintessence models and the non‐linear matter power spectrum

Quintessence has been proposed to account for dark energy (DE) in the Universe. This component causes a typical modification of the background cosmic expansion, which, in addition to its clustering properties, can leave a potentially distinctive signature on large-scale structures. Many previous studies have investigated this topic, particularly in relation to the non-linear regime of structure formation. However, no careful pre-selection of viable quintessence models with high precision cosmological data was performed. Here we show that this has led to a misinterpretation (and underestimation) of the imprint of quintessence on the distribution of large-scale structures. To this purpose, we perform a likelihood analysis of the combined Supernova Ia UNION data set and Wilkinson Microwave Anisotropy Probe 5-yr data to identify realistic quintessence models. These are specified by different model parameter values, but still statistically indistinguishable from the vanilla Lambda cold dark matter (Lambda CDM). Differences are especially manifest in the predicted amplitude and shape of the linear matter power spectrum though these remain within the uncertainties of the Sloan Digital Sky Survey data. We use these models as a benchmark for studying the clustering properties of dark matter haloes by performing a series of high-resolution N-body simulations. In this first paper, we specifically focus on the non-linear matter power spectrum. We find that realistic quintessence models allow for relevant differences of the dark matter distribution with respect to the Lambda CDM scenario well into the non-linear regime, with deviations of up to 40 per cent in the non-linear power spectrum. Such differences are shown to depend on the nature of DE, as well as the scale and epoch considered. At small scales (k similar to 1-5 h Mpc-1, depending on the redshift), the structure formation process is about 20 per cent more efficient than in Lambda CDM. We show that these imprints are a specific record of the cosmic structure formation history in DE cosmologies and therefore cannot be accounted for in standard fitting functions of the non-linear matter power spectrum.
Fornax compact object survey FCOS: On the nature of Ultra Compact Dwarf galaxies

The results of the Fornax Compact Object Survey (FCOS) are presented, complementing the first part of the FCOS described in Mieske et al. ([CITE]). The FCOS aims at investigating the nature of the Ultra Compact Dwarf galaxies (UCDs) recently discovered in the center of the Fornax cluster (Drinkwater et al. [CITE]). 280 unresolved objects with colours $0 20$ mag) at 96% confidence. The mean velocity of the bright compact objects is consistent with that of the dwarf galaxy population in Fornax, but inconsistent with that of NGC 1399's globular cluster (GC) system at 93.5% confidence. The compact objects follow a colour magnitude relation with a slope very similar to that of normal dEs, but shifted about 0.2 mag redwards. The magnitude distribution of compact objects shows a fluent transition between UCDs and GCs. A slight overpopulation of $8 \pm 4$ objects for $V<20$ mag is detected with respect to the extrapolation of NGC 1399's GC luminosity function. The spatial distribution of bright compact objects is in comparison to the faint ones more extended at 88% confidence. All our findings are consistent with the threshing scenario (Bekki et al. [CITE]), suggesting that a substantial fraction of compact Fornax members brighter than $V\simeq 20$ mag could be created by threshing dE,Ns. Fainter than $V\simeq 20$ mag, the majority of the objects seem to be genuine GCs. Our results are also consistent with merged stellar super-clusters (Fellhauer & Kroupa [CITE]) as an alternative explanation for the bright compact objects.
4-hydroxy-2(E)-Nonenal facilitates NMDA-Induced Neurotoxicity via Triggering Mitochondrial Permeability Transition Pore Opening and Mitochondrial Calcium Overload

N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity is one of the major causes for neuronal cell death during cerebral ischemic insult. Previously, we reported that the final product of lipid membrane peroxidation 4-hydroxy-2E-nonenal (HNE) synergistically increased NMDA receptor-mediated excitotoxicity (J Neurochem., 2006). In this study, we investigated the mechanism involved in the synergistic neuronal cell death induced by co-treatment with HNE and NMDA. Although neither HNE (1 µM) nor NMDA (2 µM) alone induced the death of cortical neurons, simultaneous treatment of neuronal cells with HNE and NMDA synergistically evoked the death of the cells. However, the synergistic effect on neuronal death was observed only in the presence of calcium. HNE neither increased the cytosolic calcium level ([Ca2+]i) nor altered the NMDA-induced intracellular calcium influx. However, HNE together with NMDA elevated the mitochondrial calcium level and depolarized the mitochondrial transmembrane potential. Furthermore, HNE evoked damage of isolated mitochondria at the cytosolic calcium level (200 nM), which is maximally induced by 2 µM NMDA. Consistently, ATP was depleted in neurons when treated with both HNE and NMDA together. Ciclopirox, a potent inhibitor of mitochondrial permeability transition pore opening (Br. J. Pharmacol., 2005), largely prevented the synergistic damage of mitochondria and death of cortical neurons. Therefore, although low concentrations of HNE and NMDA cannot individually induce neuronal cell death, they can evoke the neuronal cell death by synergistically accelerating mitochondrial dysfunction.
The suppression of human prostate tumor growth in mice by the intratumoral injection of a slow-release polymeric paste formulation of paclitaxel.

Most patients that present in the clinic with prostate cancer have either localized or recurrent postradiotherapy therapy tumors that may be amenable to injectable treatments using slow-release cytotoxic drugs. The objective of this preclinical study was to design an injectable polymeric paste formulation of paclitaxel for intratumoral injection into nonmetastatic human prostate tumors grown s.c. in mice. Paclitaxel was dissolved (10% w/w) in a blend of a biodegradable triblock copolymer of a random copolymer of D,L-lactide and epsilon-caprolactone (PLC) with poly(ethyleneglycol) [PEG; PLC-PEG-PLC] blended with methoxypoly(ethylene glycol) in a 40:60 ratio. Human prostate LNCaP tumors grown s.c. in castrated athymic male mice were injected with 100 microl of this paste at room temperature. Changes in tumor progression were assessed using both serum prostate-specific antigen (PSA) levels and tumor size. Paclitaxel inhibited LNCaP cell growth in vitro in a concentration-dependent fashion with an IC50 of 1 nM. Apoptosis was documented using DNA fragmentation analysis. The paste formulation solidified over a period of 1 h both in vivo and in aqueous media at 37 degrees C as the methoxypoly(ethylene glycol) component partitioned out of the insoluble PLC-PEG-PLC/paclitaxel matrix. The semisolid implant released drug at a rate of about 100 microg/day in vitro. In control mice treated with paste without paclitaxel, serum PSA levels increased from 2-8 ng/ml (mean, 4.3+/-2 ng/ml) to 60-292 ng/ml (mean, 181+/-88 ng/ml), and tumor volume increased from 30 to 1000 mm3. In mice treated with a single 100-microl injection 3 weeks after castration (early-phase treatment group), tumors decreased in volume from a mean of 43+/-19 mm3 to nonpalpable, and PSA levels decreased from a mean of 22+/-8 to 2+/-1 ng/ml by 8 weeks after castration. In mice treated 5 weeks after castration (androgen-independent tumors; late-phase treatment group), tumors decreased in volume from a mean of 233+/-136 mm3 to nonpalpable, and serum PSA decreased from 24+/-8 to 9+/-4 ng/ml. Observed side effects of the treatment were limited to minor ulceration at the needle injection site in paclitaxel-treated mice only. The controlled-release formulation can be injected via 22-gauge needles and is effective in inhibiting LNCaP tumor growth and PSA levels in mice bearing multiple nonmetastatic tumors. Paclitaxel may be an effective therapy for patients with localized tumors recurring after radiotherapy and for some patients with localized tumors who are not candidates for radical treatment.
A Factor-Based Exploration of Player's Continuation Desire in Free-to-Play Mobile Games

This paper explores the concept of Continuation Desire further by investigating the behavioral intent of players’ desire to keep playing. User experience is a complex, multifaceted topic, which is commonly studied through different aspects namely engagement, continuation desire, immersion, flow experience, motivation and enjoyment — yet it is difficult to measure. These concepts were conceptualized into different factors and thereby it was identified which of them are related. This resulted in a synthesized model that was based on the Theory of Planned Behavior model. This model takes into account the perceived user experience factors relevant for Continuation Desire and then attempts to predict players’ intention to continue playing. Structural Equation Modeling analysis was performed to validate the model and to predict the intention of continuation desire. At the same time, exploring why people continue playing, based on experiments using Candy Crush Saga, one of the most popular Free-to-Play mobile games worldwide. The findings indicate that motivation is an important factor of Continuation Desire in Free-to-Play mobile games, with engagement, enjoyment and flow being less important. This paper contributes an early work of a factor-based exploration of measuring user experience and their continuation desire.
An analysis of the development and implementation of a smartphone application for the delivery of antimicrobial prescribing policy: lessons learnt

Objectives Smartphone usage amongst clinicians is widespread. Yet smartphones are not widely used for the dissemination of policy or as clinical decision support systems. We report here on the development, adoption and implementation process of the Imperial Antimicrobial Prescribing Application across five teaching hospitals in London. Methods Doctors and clinical pharmacists were recruited to this study, which employed a mixed methods in-depth case-study design with focus groups, structured pre- and post-intervention survey questionnaires and live data on application uptake. The primary outcome measure was uptake of the application by doctors and its acceptability. The development and implementation processes were also mapped. Results The application was downloaded by 40% (376) of junior doctors with smartphones (primary target user group) within the first month and by 100% within 12 months. There was an average of 1900 individual access sessions per month, compared with 221 hits on the Intranet version of the policy. Clinicians (71%) reported that using the application improved their antibiotic knowledge. Conclusions Clinicians rapidly adopted the mobile application for antimicrobial prescribing at the point of care, enabling the policy to reach a much wider audience in comparison with paper- and desktop-based versions of the policy. Organizations seeking to optimize antimicrobial prescribing should consider utilizing mobile technology to deliver point-of-care decision support. The process revealed a series of barriers, which will need to be addressed at individual and organizational levels to ensure safe and high-quality delivery of local policy at the point of care.
Phase transitions in higher derivative gravity and gauge theory: R-charged black holes

This is a continuation of our earlier work where we constructed a phenomenologically motivated effective action of the boundary gauge theory at finite temperature and finite gauge coupling on S3 × S1. In this paper, we argue that this effective action qualitatively reproduces the gauge theory representing various bulk phases of R-charged black hole with Gauss-Bonnet correction. We analyze the system both in canonical and grand canonical ensemble.
Papers in Evolutionary Economic Geography # 05 . 01 Why is Economic Geography not an Evolutionary Science ? Towards an Evolutionary Economic Geography

The paper explains the commonalities and differences between neoclassical, institutional and evolutionary approaches that have been influential in economic geography during the last couple of decades. For all three approaches, we argue that they are in agreement in some respects and in conflict in other respects. While explaining to what extent and in what ways the Evolutionary Economic Geography approach differs from the New Economic Geography and the Institutional Economic Geography, we can specify the value-added of economic geography as an evolutionary science.
Duality of independence and interdependence: An adaptationist perspective

We propose a new framework for understanding cultural differences in self-construal by noting the duality of this construct. Based on the analysis of the adaptive roles of self-construal, we predicted that a US–Japan difference in self-construal exists in the contrast between self-expression and rejection avoidance. We confirmed these predictions using newly constructed self-construal scales. Compared to Japanese respondents, American respondents were higher on self-expression and lower on rejection avoidance. Our findings regarding the contrast between distinctiveness of the self and harmony seeking, which are traditionally discussed as the core features of independence and interdependence, did not support the standard cultural psychological view. The two groups of respondents did not differ on distinctiveness of the self and the American respondents were higher on harmony seeking than were Japanese respondents.
First Spike Latency Code for Interaural Phase Difference Discrimination in the Guinea Pig Inferior Colliculus

First spike latency has been suggested as a source of the information required for fast discrimination tasks. However, the accuracy of such a mechanism has not been analyzed rigorously. Here, we investigate the utility of first spike latency for encoding information about the location of a sound source, based on the responses of inferior colliculus (IC) neurons in the guinea pig to interaural phase differences (IPDs). First spike latencies of many cells in the guinea pig IC show unimodal tuning to stimulus IPD. We investigated the discrimination accuracy of a simple latency code that estimates stimulus IPD from the preferred IPD of the single cell that fired first. Surprisingly, despite being based on only a single spike, the accuracy of the latency code is comparable to that of a conventional rate code computed over the entire response. We show that spontaneous firing limits the capacity of the latency code to accumulate information from large neural populations. This detrimental effect can be overcome by generalizing the latency code to estimate the stimulus IPD from the preferred IPDs of the population of cells that fired the first n spikes. In addition, we show that a good estimate of the neural response time to the stimulus, which can be obtained from the responses of the cells whose response latency is invariant to stimulus identity, limits the detrimental effect of spontaneous firing. Thus, a latency code may provide great improvement in response speed at a small cost to the accuracy of the decision.
ON CLOSED FORM SEMIPARAMETRIC ESTIMATORS FOR MEASUREMENT ERROR MODELS

We examine the locally ecien t semiparametric estimator proposed by Tsiatis and Ma (2004) in the situation when a sucien t and complete statistic exists. We derive a closed form solution and show that when implemented in gen- eralized linear models with normal measurement error, this estimator is equivalent to the ecien t score estimator in Stefanski and Carroll (1987). We also demonstrate how other consistent semiparametric estimators naturally emerge. The method is used in an extension of the usual generalized linear models.
ANTIGENS OF LEUKEMIAS INDUCED BY NATURALLY OCCURRING MURINE LEUKEMIA VIRUS: THEIR RELATION TO THE ANTIGENS OF GROSS VIRUS AND OTHER MURINE LEUKEMIA VIRUSES

Leukemias can be induced in W/Fu inbred rats by neonatal inoculation of normal thymus cells of C58 mice. These leukemias are not transplantable to C58 mice or to adult W/Fu rats, but they can be kept in passage in W/Fu rats aged 0 to 7 days. Adult W/Fu rats inoculated repeatedly with these isogenic leukemias produce cytotoxic and precipitating antibodies. These antisera are of particular value in the analysis of the antigens of leukemia cells and of leukemia viruses because their mode of preparation precludes the formation of antibody against any normal constituents of the cell. Analysis based on the cytotoxic test indicates the presence of 2 distinct cell surface antigens in leukemias induced by Passage A Gross virus or occurring spontaneously in mice of high-incidence strains. All leukemias and other tissues known to contain G (Gross) leukemia antigen have both determinants, but certain leukemias of low-incidence strains have only 1 of them and so were previously classified G-. Immunoprecipitation with these antisera reveals the presence of a cellular antigen common to G+ cells and absent from G- cells; the same antigen can be demonstrated in ether-treated Gross virus, but not in intact virus. This antigen is present also in ether-treated preparations of the Friend, Moloney, and Rauscher leukemia viruses, but not in Bittner (mammary tumor) virus. Thus it may be regarded as a group-specific antigen of murine leukemia viruses, in contrast to the type-specific cellular antigens demonstrable by the cytotoxic test. Four additional antigens associated with leukemias induced by wild-type Gross virus have been demonstrated by immunoprecipitation, but their relation to viral and cellular antigens has not been determined.
Calculating Consequences: Brain Systems That Encode the Causal Effects of Actions

The capacity to accurately evaluate the causal effectiveness of our actions is key to successfully adapting to changing environments. Here we scanned subjects using functional magnetic resonance imaging while they pressed a button to earn money as the response–reward relationship changed over time. Subjects' judgments about the causal efficacy of their actions reflected the objective contingency between the rate of button pressing and the amount of money they earned. Neural responses in medial orbitofrontal cortex and dorsomedial striatum were modulated as a function of contingency, by increasing in activity during sessions when actions were highly causal compared with when they were not. Moreover, medial prefrontal cortex tracked local changes in action–outcome correlations, implicating this region in the on-line computation of contingency. These results reveal the involvement of distinct brain regions in the computational processes that establish the causal efficacy of actions, providing insight into the neural mechanisms underlying the adaptive control of behavior.
The Relation of Self-Compassion and Anger Control Dimensions With Suicide Ideation in University Students

BACKGROUND: Suicide ideation is one of the strongest risk factors for completed suicide. There have been many reports of significant increases in suicide and suicide attempts in university students. Objectives: This study was performed to determine the relationship of self-compassion and anger control dimensions with suicide ideation. Methods: The method of this study was descriptive and correlation. The statistical population comprised students of Mohaghegh Ardabili university in the second semester of the 2012 - 2013 school year. One hundred and fifty subjects were selected from this population by random multistage clustering. They were asked to answer questionnaires about suicide ideation, self-compassion, and multidimensional anger. The collected data were analyzed by Pearson correlation coefficient and multiple regression tests. Results: The results of the Pearson correlation coefficient tests showed that suicide ideation was negatively correlated with self-compassion ) r = -0.19; P Conclusions: Based on the results, improving self-compassion and anger-control skills are suggested as ways to decrease suicide ideation. Keywords: Self-Compassion; Anger Control Dimensions; Suicide Ideation; University Students Language: en
Repetitive TMS as a Probe of Mood In Health and Disease

Abstract Recent advances in functional neuroimaging (including positron emission tomography, single-photon emission tomography, and fast magnetic resonance imaging) have allowed better understanding of the brain regions involved in regulating normal and pathological moods. Repetitive transcranial magnetic stimulation (rTMS) has the ability to stimulate or temporarily impair brain regions, which makes it a powerful tool for directly testing theories of the neurologic basis of mood regulation.
Control of Herbaspirillum seropedicaeNifA Activity by Ammonium Ions and Oxygen

ABSTRACT The activity of a truncated form of Herbaspirillum seropedicae NifA in different genetic backgrounds showed that its regulatory domain is involved in nitrogen control but not in O2 sensitivity or Fe dependence. The model for nitrogen control involving PII could thus apply to the proteobacteria at large. NifA may have a role in controlling ADP-ribosylation of nitrogenase inAzospirillum brasilense.
The Phonetic Potential of Nonhuman Vocal Tracts: Comparative Cineradiographic Observations of Vocalizing Animals

For more than a century it has been noted that the adult human vocal tract differs from that of other mammals, in that the resting position of the larynx is much lower in humans. While animals habitually breathe with the larynx inserted into the nasal cavity, adult humans are unable to do this. This anatomical difference has been cited as an important factor limiting the vocal potential of nonhuman animals, because the low larynx of humans allows a wider range of vocal tract shapes and thus formant patterns than is available to other species. However, it is not clear that the static anatomy of dead animals provides an accurate guide to the phonetic potential of the living animal's vocal tract. Here I present X-ray video observations of four mammal species (dogs Canis familiaris, goats Capra hircus, pigs Sus scrofa and cotton-top tamarins Sagunius oedipus). In all four species, the larynx was lowered from the nasopharynx, and the velum was closed, during loud calls. In dogs this temporary lowering was particularly pronounced. Although preliminary, these results suggest that the nonhuman vocal tract is more flexible than previously supposed, and that static postmortem anatomy provides an incomplete guide to the phonetic potential of nonhuman animals. The implications of these findings for theories of speech evolution are discussed.