Miracle-dz/UniFAR-FTUs huggingface dataset:
Unified Optical-Thermal Four-Stream Radiative Transfer Theory for Homogeneous Vegetation Canopies

Foliage and soil temperatures are key variables for assessing the exchanges of turbulent heat fluxes between vegetated land and the atmosphere. Using multiple-view-angle thermal-infrared (TIR) observations, the temperatures of soil and vegetation may be retrieved. However, particularly for sparsely vegetated areas, the soil and vegetation component temperatures in the sun and in the shade may be very different depending on the solar radiation, the physical properties of the surface, and the meteorological conditions. This may interfere with a correct retrieval of component temperatures, but it might also yield extra information related to canopy structure. Both are strong reasons to investigate this phenomenon in some more detail. To this end, the relationship between the TIR radiance directionality and the component temperatures has been analyzed. In this paper, we extend the four-stream radiative transfer (RT) formalism of the Scattering by Arbitrarily Inclined Leaves model family to the TIR domain. This new approach enables us to simulate the multiple scattering and emission inside a geometrically homogenous but thermodynamically heterogeneous canopy for optical as well as thermal radiation using the same modeling framework. In this way top-of-canopy thermal radiances observed under multiple viewing angles can be related to the temperatures of sunlit and shaded soil and sunlit and shaded leaves. In this paper, we describe the development of this unified optical-thermal RT theory and demonstrate its capabilities. A preliminary validation using an experimental data set collected in the Shunyi remote sensing field campaign in China is briefly addressed
Systematically missing confounders in individual participant data meta-analysis of observational cohort studies

One difficulty in performing meta‐analyses of observational cohort studies is that the availability of confounders may vary between cohorts, so that some cohorts provide fully adjusted analyses while others only provide partially adjusted analyses. Commonly, analyses of the association between an exposure and disease either are restricted to cohorts with full confounder information, or use all cohorts but do not fully adjust for confounding. We propose using a bivariate random‐effects meta‐analysis model to use information from all available cohorts while still adjusting for all the potential confounders. Our method uses both the fully adjusted and the partially adjusted estimated effects in the cohorts with full confounder information, together with an estimate of their within‐cohort correlation. The method is applied to estimate the association between fibrinogen level and coronary heart disease incidence using data from 154 012 participants in 31 cohorts. † One hundred and ninety‐nine participants from the original 154 211 withdrew their consent and have been removed from this analysis. Copyright © 2009 John Wiley & Sons, Ltd.
Cyclic dinucleotides modulate human T‐cell response through monocyte cell death

Cyclic dinucleotides, a class of microbial messengers, have been recently identified in bacteria, but their activity in humans remains largely unknown. Here, we have studied the function of cyclic dinucleotides in humans. We found that c‐di‐AMP and cGAMP, two adenosine‐based cyclic dinucleotides, activated T lymphocytes in an unusual manner through monocyte cell death. c‐di‐AMP and cGAMP induced the selective apoptosis of human monocytes, and T lymphocytes were activated by the direct contact with these dying monocytes. The ensuing T‐cell response comprised cell‐cycle exit, phenotypic maturation into effector memory cells and proliferation arrest, but not cell death. This quiescence was transient since T cells remained fully responsive to further restimulation. Together, our results depict a novel activation pattern for human T lymphocytes: a transient quiescence induced by c‐di‐AMP‐ or cGAMP‐primed apoptotic monocytes.
A population of eruptive variable protostars in VVV

We present the discovery of 816 high-amplitude infrared variable stars (? Ks > 1 mag) in 119 deg2 of the Galactic mid-plane covered by the VISTA Variables in the Via Lactea (VVV) survey. Almost all are new discoveries and about 50? per? cent are young stellar objects (YSOs). This provides further evidence that YSOs are the commonest high-amplitude infrared variable stars in the Galactic plane. In the 2010–2014 time series of likely YSOs, we find that the amplitude of variability increases towards younger evolutionary classes (class I and flat-spectrum sources) except on short time-scales ( 100 d) and 162 short-term variables. Eruptive YSOs and faders tend to have the highest amplitudes and eruptive systems have the reddest spectral energy distribution (SEDs). Follow-up spectroscopy in a companion paper verifies high accretion rates in the eruptive systems. Variable extinction is disfavoured by the two epochs of colour data. These discoveries increase the number of eruptive variable YSOs by a factor of at least 5, most being at earlier stages of evolution than the known FUor and EXor types. We find that eruptive variability is at least an order of magnitude more common in class I YSOs than class II YSOs. Typical outburst durations are 1–4 yr, between those of EXors and FUors. They occur in 3–6 per cent of class I YSOs over a 4 yr time span.
Sequential Influences of Leukemia-Specific and Genetic Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the National Cancer Research Network Acute Myeloid Leukemia 14 and 15 Trials

Purpose: P-glycoprotein (Pgp) is a major prognostic factor for chemotherapy failure in acute myeloid leukemia (AML). This study compared the influence of genetic and leukemia-specific factors on Pgp. Experimental Design: Eight hundred and seventeen samples were studied prospectively for Pgp protein expression and function and G1199A, G2677T, and C3435T polymorphisms in the encoding gene ABCB1. Results: Age, low WBC count, high bcl-2, secondary AML and myelodysplastic syndrome, and adverse cytogenetics all correlated strongly with high Pgp (MRK16) protein expression. However, ABCB1 3435TT homozygosity was negatively correlated with Pgp. Pgp protein is only expressed in 41% of samples such that the negative effect of the polymorphism was not seen at baseline Pgp levels but was marked in the upper 41% of samples (MRK16 Δmean fluorescence intensity of 75th centile sample = 9 units for TT variant samples and 26 units for CC/CT; P = 0.003). However, no association was found between genetic factors and Pgp function using rhodamine 123 accumulation. Conclusions: The genetic polymorphism 3435TT (which results in unstable mRNA) has a significant effect on Pgp expression, but this is only seen in ∼40% of cases in which mRNA and protein are detectable. Moreover, leukemia-specific factors, such as low WBC count and poor risk cytogenetics, have a much greater effect than genetic polymorphisms on Pgp expression in AML blasts.
Mass Distribution in Rotating Thin-Disk Galaxies According to Newtonian Dynamics

An accurate computational method is presented for determining the mass distribution in a mature spiral galaxy from a given rotation curve by applying Newtonian dynamics for an axisymmetrically rotating thin disk of finite size with or without a central spherical bulge. The governing integral equation for mass distribution is transformed via a boundary-element method into a linear algebra matrix equation that can be solved numerically for rotation curves with a wide range of shapes. To illustrate the effectiveness of this computational method, mass distributions in several mature spiral galaxies are determined from their measured rotation curves. All the surface mass density profiles predicted by our model exhibit approximately a common exponential law of decay, quantitatively consistent with the observed surface brightness distributions. When a central spherical bulge is present, the mass distribution in the galaxy is altered in such a way that the periphery mass density is reduced, while more mass appears toward the galactic center. By extending the computational domain beyond the galactic edge, we can determine the rotation velocity outside the cut-off radius, which appears to continuously decrease and to gradually approach the Keplerian rotation velocity out over twice the cut-off radius. An examination of circular orbit stability suggests that galaxies with flat or rising rotation velocities are more stable than those with declining rotation velocities especially in the region near the galactic edge. Our results demonstrate the fact that Newtonian dynamics can be adequate for describing the observed rotation behavior of mature spiral galaxies.
An Exploratory Study of a Color Association Exercise for the Assessment of Verbal Creative Ability.

ion: Verbal Abstraction was also scored on a three-category rating scale. Productions were rated Low, Medium, or High, according to the utilization of highly abstract phrases, i.e., those characterized by symbolic, allegorical, and anthropomorphic qualities. The following poem, for example, received a High rating on Abstraction: Red is the balloon and the autumn apples, Red are the faces of fighters
UvA-DARE (Digital Academic Repository) Networks of reader and country status: an analysis of Mendeley reader statistics

The number of papers published in journals indexed by the Web of Science core collection is steadily increasing. In recent years, nearly two million new papers were published each year; somewhat more than one million papers when primary research papers are considered only (articles and reviews are the document types where primary research is usually reported or reviewed). However, who reads these papers? More precisely, which groups of researchers from which (self-assigned) scientific disciplines and countries are reading these papers? Is it possible to visualize readership patterns for certain countries, scientific disciplines, or academic status groups? One popular method to answer these questions is a network analysis. In this study, we analyze Mendeley readership data of a set of 1,133,224 articles and 64,960 reviews with publication year 2012 to generate three di ff erent networks: (1) The network based on disciplinary a ffi liations of Mendeley readers contains four groups: (i) biology, (ii) social sciences and humanities (including relevant computer sciences), (iii) bio-medical sciences, and (iv) natural sciences and engineering. In all four groups, the category with the addition “miscellaneous” prevails. (2) The network of co-readers in terms of professional status shows that a common interest in papers is mainly shared among PhD students, Master’s students, and postdocs. (3) The country network focusses on global readership patterns: a group of 53 nations is identified as core to the scientific enterprise, including Russia and China as well as two thirds of the OECD (Organisation for Economic Co-operation and Development) countries.
Guanfacine enhances inhibitory control and attentional shifting in early abstinent cocaine-dependent individuals

Objectives: Attenuation of adrenergic drive and cognitive enhancement, via stimulation of alpha2 pre- and post-synaptic receptors, may selectively enhance executive performance in early abstinent cocaine-dependent individuals. As these cognitive processes underpin important treatment-related behaviors, the alpha2 agonist, guanfacine HCl, may represent an effective pharmaco-therapeutic intervention. Methods: Twenty-five early abstinent cocaine-dependent individuals were administered a battery of neurocognitive tasks on entry into treatment (baseline) and again following 3 weeks of either placebo or guanfacine treatment (up to 3 mg). Tasks included: Stop Signal, Stroop, 3-Dimentional Intra-dimensional/Extra-dimensional (IDED) task, Spatial Working Memory (SWM), Paired Associates Learning (PAL), Verbal Fluency and the Rey Auditory Verbal Learning Test (RAVLT). Results: Compared with placebo, the guanfacine group demonstrated attenuated anxiety and negative affect as well as improved performance on selective executive tests. This included fewer directional errors on the stop signal task, fewer errors on the extra-dimensional shift component of the IDED task and better attentional switching during verbal fluency. Guanfacine did not improve strategic working memory or peripheral memory. Conclusion: Guanfacine improves selective cognitive processes which may underlie salient treatment-related regulatory behaviors. Alpha2 agonists may therefore represent important agents for cocaine dependence.
Treatment of Class II Malocclusion and Impacted Canines with Two-phase Orthodontic Treatment

Twin Block appliance has been widely used for the treatment of Class II malocclusions in growing subjects, due to its versatility and its highly compliance nature. There are certain clinical indications where functional appliances can be used successfully in Class II malocclusion as in a growing patient. In using these appliances, the main concern is compliance of patients. This appliance simplifies the progression of treatment with fixed orthodontic braces later on. In this case, a 14-year-old adolescent was treated with Twin Block appliance followed by fixed appliances for finishing and detailing. The design and treatment effects are demonstrated in this case report.
Do Bills of Rights Matter?: An Examination of Court Change, Judicial Ideology, and the Support Structure for Rights in Canada

Competing theories regarding the development of a “rights revolution” in Canada have appeared in the judicial and constitutional literature in recent years. On the one hand, scholars argue that the profound effects often attributed to the Charter of Rights and Freedoms are substantially overstated, and conventional analyses have overlooked the more important role of changes in what is called the “support structure” for rights. Others have advanced a competing theory that the Charter created an expansion of civil liberties. We take advantage of an extensive dataset on the decisions of the Supreme Court of Canada to provide a more systematic test of these competing theories. We conclude that the adoption of the Charter had effects on both the rights agenda and the constitutional issues agenda of the Court, which were both substantively large and statistically significant. There was some indication that changes in agenda control mattered, but the effects were not consistent across our time-series models. The more limited claim that increases in the support structure are one of multiple factors that are associated with agenda change received only mixed support. In short, we found that bills of rights do matter. This article is available in Osgoode Hall Law Journal: http://digitalcommons.osgoode. yorku.ca/ohlj/vol51/iss1/8
Decidability of Fair Termination of Gossip Protocols

Gossip protocols deal with a group of communicating agents, each holding some private information, and aim at arriving at a situation in which all the agents know each other secrets. Distributed epistemic gossip protocols are particularly simple distributed programs that use as guards formulas from an epistemic logic. We showed recently that the implementability of these distributed gossip protocols and the problems of their partial correctness and termination are decidable, but the problem of decidability of their fair termination was left open. We study here rule-fair and agent-fair termination of these protocols and show that both properties are decidable.
Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

Drosophila Wingless (Wg) is the founding member of the Wnt family of secreted proteins. During the wing development, Wg acts as a morphogen whose concentration gradient provides positional cues for wing patterning. The molecular mechanism(s) of Wg gradient formation is not fully understood. Here, we systematically analyzed the roles of glypicans Dally and Dally-like protein (Dlp), the Wg receptors Frizzled (Fz) and Fz2, and the Wg co-receptor Arrow (Arr) in Wg gradient formation in the wing disc. We demonstrate that both Dally and Dlp are essential and have different roles in Wg gradient formation. The specificities of Dally and Dlp in Wg gradient formation are at least partially achieved by their distinct expression patterns. To our surprise, although Fz2 was suggested to play an essential role in Wg gradient formation by ectopic expression studies, removal of Fz2 activity does not alter the extracellular Wg gradient. Interestingly, removal of both Fz and Fz2, or Arr causes enhanced extracellular Wg levels, which is mainly resulted from upregulated Dlp levels. We further show that Notum, a negative regulator of Wg signaling, downregulates Wg signaling mainly by modifying Dally. Last, we demonstrate that Wg movement is impeded by cells mutant for both dally and dlp. Together, these new findings suggest that the Wg morphogen gradient in the wing disc is mainly controlled by combined actions of Dally and Dlp. We propose that Wg establishes its concentration gradient by a restricted diffusion mechanism involving Dally and Dlp in the wing disc.
Collective Emotions Online and Their Influence on Community Life

Background E-communities, social groups interacting online, have recently become an object of interdisciplinary research. As with face-to-face meetings, Internet exchanges may not only include factual information but also emotional information – how participants feel about the subject discussed or other group members. Emotions in turn are known to be important in affecting interaction partners in offline communication in many ways. Could emotions in Internet exchanges affect others and systematically influence quantitative and qualitative aspects of the trajectory of e-communities? The development of automatic sentiment analysis has made large scale emotion detection and analysis possible using text messages collected from the web. However, it is not clear if emotions in e-communities primarily derive from individual group members' personalities or if they result from intra-group interactions, and whether they influence group activities. Methodology/Principal Findings Here, for the first time, we show the collective character of affective phenomena on a large scale as observed in four million posts downloaded from Blogs, Digg and BBC forums. To test whether the emotions of a community member may influence the emotions of others, posts were grouped into clusters of messages with similar emotional valences. The frequency of long clusters was much higher than it would be if emotions occurred at random. Distributions for cluster lengths can be explained by preferential processes because conditional probabilities for consecutive messages grow as a power law with cluster length. For BBC forum threads, average discussion lengths were higher for larger values of absolute average emotional valence in the first ten comments and the average amount of emotion in messages fell during discussions. Conclusions/Significance Overall, our results prove that collective emotional states can be created and modulated via Internet communication and that emotional expressiveness is the fuel that sustains some e-communities.
Sensors for Highly Toxic Gases: Methylamine and Hydrogen Chloride Detection at Low Concentrations in an Ionic Liquid on Pt Screen Printed Electrodes

Commercially available Pt screen printed electrodes (SPEs) have been employed as possible electrode materials for methylamine (MA) and hydrogen chloride (HCl) gas detection. The room temperature ionic liquid (RTIL) 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([C2mim][NTf2]) was used as a solvent and the electrochemical behaviour of both gases was first examined using cyclic voltammetry. The reaction mechanism appears to be the same on Pt SPEs as on Pt microelectrodes. Furthermore, the analytical utility was studied to understand the behaviour of these highly toxic gases at low concentrations on SPEs, with calibration graphs obtained from 10 to 80 ppm. Three different electrochemical techniques were employed: linear sweep voltammetry (LSV), differential pulse voltammetry (DPV) and square wave voltammetry (SWV), with no significant differences in the limits of detection (LODs) between the techniques (LODs were between 1.4 to 3.6 ppm for all three techniques for both gases). The LODs achieved on Pt SPEs were lower than the current Occupational Safety and Health Administration Permissible Exposure Limit (OSHA PEL) limits of the two gases (5 ppm for HCl and 10 ppm for MA), suggesting that Pt SPEs can successfully be combined with RTILs to be used as cheap alternatives for amperometric gas sensing in applications where these toxic gases may be released.
Bimodal distribution of Trypanosoma cruzi antibody levels in blood donors from a highly endemic area of Argentina: what is the significance of low‐reactive samples?

Low‐level seroreactive donor samples that are inconsistently detected by different Trypanosoma cruzi immunoassays are common, but the population distribution has not been reported in an endemic region. The objective was to understand the distribution of low‐level reactive samples using highly sensitive immunoassays and the relationship with epidemiologic evidence of exposure to T. cruzi.
Recovering Line-Networks in Images by Junction-Point Processes

The automatic extraction of line-networks from images is a well-known computer vision issue. Appearance and shape considerations have been deeply explored in the literature to improve accuracy in presence of occlusions, shadows, and a wide variety of irrelevant objects. However most existing works have ignored the structural aspect of the problem. We present an original method which provides structurally-coherent solutions. Contrary to the pixel-based and object-based methods, our result is a graph in which each node represents either a connection or an ending in the line-network. Based on stochastic geometry, we develop a new family of point processes consisting in sampling junction-points in the input image by using a Monte Carlo mechanism. The quality of a configuration is measured by a probability density which takes into account both image consistency and shape priors. Our experiments on a variety of problems illustrate the potential of our approach in terms of accuracy, flexibility and efficiency.
Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354

Many flaviviruses are significant human pathogens, with the humoral immune response playing an essential role in restricting infection and disease. CR4354, a human monoclonal antibody isolated from a patient, neutralizes West Nile virus (WNV) infection at a postattachment stage in the viral life-cycle. Here, we determined the structure of WNV complexed with Fab fragments of CR4354 using cryoelectron microscopy. The outer glycoprotein shell of a mature WNV particle is formed by 30 rafts of three homodimers of the viral surface protein E. CR4354 binds to a discontinuous epitope formed by protein segments from two neighboring E molecules, but does not cause any detectable structural disturbance on the viral surface. The epitope occurs at two independent positions within an icosahedral asymmetric unit, resulting in 120 binding sites on the viral surface. The cross-linking of the six E monomers within one raft by four CR4354 Fab fragments suggests that the antibody neutralizes WNV by blocking the pH-induced rearrangement of the E protein required for virus fusion with the endosomal membrane.