Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluating the Impact of French Employment Policies on Individual Labour Market Histories

This paper deals with the evaluation of some public employment policies set up in France during the 1980's to improve the labour market prospects of unskilled young workers. The evaluation implemented in this paper is restricted to the impact of such public measures on durations and outcomes of subsequent spells of unemployment and employment. The econometric study is conducted with non-experimental longitudinal microdata recording individual labour market histories. A particular attention is paid to the differential effects of various types of measures, according to the educational level of recipients. Programmes involving a higher level of on-the-job training, such as alternating work/training programmes in private firms, are principally beneficial to the less educated young workers. In contrast, for more educated young workers, "work fare" programmes in the public sector decrease the intensity of transition from the subsequent unemployment spell to regular jobs; for that subgroup, "work fare" programmes may act as a signal of low employment performance.
A new perspective on board composition and firm performance in an emerging market

Purpose – This paper seeks to examine the relationship between board composition and firm performance using a board‐level aggregation variable.Design/methodology/approach – This study uses linear regression to analyze the relationship between board role typology and firm performance using a panel data set of 277 non‐financial listed Malaysian firms over the period 2002‐2007.Findings – The empirical results show that firm‐boards with a high representation of outside and foreign directors are associated with better performance compared to those firm‐boards that have a majority of insider executive and affiliated non‐executive directors.Research limitations/implications – The findings seem to imply that in widely owned firms a higher proportion of outsiders on the board reduces under‐investment and agency problems, which has significant economic implications.Originality/value – This is the first study to use a board‐level aggregation variable to demonstrate the impact of boards' resourcefulness on firm perfo.
Evaluation of the Secretome Profile and Functional Characteristics of Human Bone Marrow Mesenchymal Stromal Cells-Derived Conditioned Medium Suggest Potential for Skin Rejuvenation

Background/Purpose: Multipotent bone marrow-derived mesenchymal stromal cells (BMMSC) have been shown to possess the potential for tissue regeneration. The application of mesenchymal stromal cells (MSC)-derived growth factors and cytokines (GF/CKs) has been implicated for the repair and regeneration of the damaged skin that occurs due to aging and exposure to environmental stress factors. Methods: We have used both qualitative and quantitative measurements of the GF/CKs from the conditioned medium (CM) of a pooled population of BMMSC by antibody array analysis as well as by enzyme-linked immunosorbent assay (ELISA). Furthermore, the CM was also used in a variety of in vitro biological assays to measure its protective properties in human skin fibroblasts. Results: We have characterized the secretome of BMMSC by analyzing the composition of the CM using a forty-one growth factor array system. Thirteen of these GF/CK/extra cellular matrix (ECM)/ matrix metalloproteinases (MMP)-inhibitors in the CM were quantified owing to their involvement in skin repair cascade. In addition, we report that the BMMSC-CM was also able to protect dermal fibroblasts against tert-Butyl hydro peroxide (tbOH) induced oxidative stress and ultra violet B (UV-B) radiation induced cell damage. Conclusion: Based on the data presented here, we propose that BMMSC-derived CM may have the potential to promote health and rejuvenation of the aging skin.
Criminal Victimisation in International Perspective

This report presents the key results of the crime victim surveys that were carried out as part of the fifth sweep of the International Crime Victim Surveys (ICVS) conducted in 2004/2005. A large portion of the these data are derived from the European Survey on Crime and Safety (EU ICS), organised by a consortium lead by Gallup Europe and co-financed by the European Commission, DGRTD. Wherever possible, results on 2004 have been compared with results from surveys carried out in earlier rounds since 1989. The ICVS and EU ICS cover ten conventional crimes, broken down into vehicle related crimes (theft of a car, theft from a car, theft of a motorcycle or moped, theft of a bicycle), burglary, attempted burglary, theft of personal property and contact crimes (robbery, sexual offences and assault & threat). In most countries in this report, questions have been added to the questionnaire on experiences with street level corruption, consumer fraud, including internet-based fraud and credit card theft, drug-related problems and hate crime. For most categories of crime trends over time can be studied in a broad selection of countries. Other subjects covered by the questionnaire are reporting to the police, satisfaction with the police, distribution and need of victim support, fear of crime, use of preventive measures and attitudes towards sentencing. This report presents data from 30 countries, including the majority of developed nations. Also the data from 33 main cities of a selection of developed and developing countries are presented in this report. Altogether data are presented from 38 different countries. A full text translation of this report in Spanish is also available.
Does CEO Duality Constrain Board Independence? Some Evidence from Audit Pricing

This study examines whether CEO duality affects the association between board independence and demand for higher quality audits, proxied by audit fee. The findings show that there is a positive association between board independence and audit fees. This result is consistent with findings of Carcello et al. (2002) that more independent boards demand higher audit quality and effort. However, this positive association is only present in firms without CEO duality, thus suggesting that CEO duality constrains board independence. The results support recommendations against CEO duality by showing that dominant CEOs may compromise the independence of their board of directors. Additionally, evidence is provided that board size (the number of directors on the board) is positively associated with audit fee pricing. This is consistent with prior studies that indicate that larger board sizes are associated with inefficiency and negative firm performance.
The Serum Very-Low-Density Lipoprotein Serves as a Restriction Factor against Hepatitis C Virus Infection

ABSTRACT Recent studies demonstrated that transgenic mice expressing key human hepatitis C virus (HCV) receptors are susceptible to HCV infection, albeit at very low efficiency. Robust mouse models of HCV infection and replication are needed to determine the importance of host factors in HCV replication, pathogenesis, and carcinogenesis as well as to facilitate the development of antiviral agents and vaccines. The low efficiency of HCV replication in the humanized mouse models is likely due to either the lack of essential host factors or the presence of restriction factors for HCV infection and/or replication in mouse hepatocytes. To determine whether HCV infection is affected by restriction factors present in serum, we examined the effects of mouse and human sera on HCV infectivity. Strikingly, we found that mouse and human sera potently inhibited HCV infection. Mechanistic studies demonstrated that mouse serum blocked HCV cell attachment without significant effect on HCV replication. Fractionation analysis of mouse serum in conjunction with targeted mass spectrometric analysis suggested that serum very-low-density lipoprotein (VLDL) was responsible for the blockade of HCV cell attachment, as VLDL-depleted mouse serum lost HCV-inhibitory activity. Both purified mouse and human VLDL could efficiently inhibit HCV infection. Collectively, these findings suggest that serum VLDL serves as a major restriction factor of HCV infection in vivo. The results also imply that reduction or elimination of VLDL production will likely enhance HCV infection in the humanized mouse model of HCV infection and replication. IMPORTANCE HCV is a major cause of liver diseases, such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Recently, several studies suggested that humanized mouse or transgenic mouse expressing key HCV human receptors became susceptible to HCV infection. However, HCV infection and replication in the humanized animals were very inefficient, suggesting either the lack of cellular genes important for HCV replication or the presence of restriction factors inhibiting HCV infection and replication in the mouse. In this study, we found that both mouse and human sera effectively inhibited HCV infection. Mechanistic studies demonstrated that VLDL is the major restriction factor that blocks HCV infection. These findings suggest that VLDL is beneficial to patients by restricting HCV infection. More importantly, our findings suggest that elimination of VLDL will lead to the development of more robust mouse models for the study of HCV pathogenesis, host response to HCV infection, and evaluation of HCV vaccines.
2001 EUROBAROMETER data on digital divides and ICT-disparities in Eu15

Due to the rapid increase in the spread and relevance of modern information and communication technologies, informational inequalities between and within nations have gained growing attention in science and policy. These inequalities are often and synonymously called "digital divides" or "ICT-disparities". This paper sums up the most important empirical findings of the SEAMATE project on some forms and aspects of digital divides and ICT-disparities in Europe. It is based on a disaggregated analysis of 2001 EUROBAROMETER survey data on the access to and usage of ICT in 15 member states of the European Union. The second section is dedicated to the analysis of national and socio-demographic disparities in computer, internet and mobile phone usage. In the third section, we will analyse the home ownership of (or access to) these three information and communication technologies. The final two sections deal solely with computers and investigate the relationship between the domestic ownership (access) and factual usage of computers and the spatial contexts (places) of computer usage.
Why persistent high inflation impedes growth? An empirical assessment of threshold level of inflation for India

In the policy debate on growth–inflation trade-off and the role of monetary policy in managing the trade-off in the short-run, theoretical and empirical research suggests the presence of a country specific threshold level of inflation. Empirical findings of this paper suggest that for India the threshold level of inflation could be around 6%. The inflation target for monetary policy may have to be somewhat lower than the growth maximizing threshold, since any positive inflation could be a risk to inclusive and sustainable growth objective.
Satellite-Scale Snow Water Equivalent Assimilation into a High-Resolution Land Surface Model

Four methods based on the ensemble Kalman filter (EnKF) are tested to assimilate coarse-scale (25 km) snow water equivalent (SWE) observations (typical of passive microwave satellite retrievals) into finescale (1 km) land model simulations. Synthetic coarse-scale observations are assimilated directly using an observation operator for mapping between the coarse and fine scales or, alternatively, after disaggregation (regridding) to the finescale model resolution prior to data assimilation. In either case, observations are assimilated either simultaneously or independently for each location. Results indicate that assimilating disaggregated finescale observations independently (method 1D-F1) is less efficient than assimilating a collection of neighboring disaggregated observations (method 3D-Fm). Direct assimilation of coarse-scale observations is superior to a priori disaggregation. Independent assimilation of individual coarse-scale observations (method 3D-C1) can bring the overall mean analyzed field close to the truth, but does not necessarily improve estimates of the finescale structure. There is a clear benefit to simultaneously assimilating multiple coarse-scale observations (method 3D-Cm) even as the entire domain is observed, indicating that underlying spatial error correlations can be exploited to improve SWE estimates. Method 3D-Cm avoids artificial transitions at the coarse observation pixel boundaries and can reduce the RMSE by 60% when compared to the open loop in this study.
Survival analysis of adult patients with ALL in Mexico City: first report from the Acute Leukemia Workgroup (ALWG) (GTLA)

Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by the clonal expansion of hematopoietic lymphoid progenitors. With new target therapies, the survival of adults with ALL has improved in the past few decades. Unfortunately, there are no large ALL patient series in many Latin American countries. Data from the Acute Leukemia Workgroup that includes five Mexico City referral centers were used. Survival was estimated for adult patients with ALL during 2009–2015. In total, 559 adults with ALL were included. The median age was 28 years; 67% were classified into the adolescent and young adult group. Cytogenetic information was available in 54.5% of cases. Of the 305 analyzed cases, most had a normal caryotype (70.5%) and Philadelphia‐positive was present in 16.7%. The most commonly used treatment regimen was hyper‐CVAD. In approximately 20% of cases, there was considerable delay in the administration of chemotherapy. Primarily refractory cases accounted for 13.1% of patients. At the time of analysis, 26.7% of cases had survived. The 3‐year overall survival was 22.1%. The main cause of death was disease progression in 228 (55.6%). Clinical and public health strategies are needed to improve diagnosis, treatment and survivorship care for adult with ALL. This multicentric report represents the largest series in Mexico of adult ALL patients in which a survival analysis and risk identification were obtained.
The effect of starvation on insulin secretion and glucose metabolism in mouse pancreatic islets.

1. Rates of insulin secretion, glucose utilization, lactate output, incorporation of glucose into glycogen, contents of glucose 6-phosphate, fructose 1,6-diphosphate and ATP, and maximally extractable enzyme activities of hexokinase, high-K(m) glucose-phosphorylating activity (;glucokinase'), glucose 6-phosphatase and unspecific acid phosphatase were measured in isolated pancreatic islets from fed and 48-h-starved mice. 2. In the fed state insulin secretion from isolated islets was increased five- to six-fold when the extracellular glucose concentration was raised from 2.5mm to 16.7mm; 5mm-caffeine potentiated this effect. The secretory response to glucose of islets from mice starved for 48h was diminished at all glucose concentrations from 2.5mm up to approx. 40mm. Very high glucose concentrations (60mm and above) restored the secretory response to that found in the fed state, suggesting that the K(m) value for the overall secretory process had been increased (approx. fourfold) by starvation. Addition of 5mm-caffeine to islets from starved mice also restored the insulin secretory response to 2.5-16.7mm-glucose to normal values. 3. Extractable hexokinase, ;glucokinase', glucose 6-phosphatase and unspecific phosphatase activities were not changed by starvation. 4. Glucose utilization and glycolysis (measured as the rate of formation of (3)H(2)O from [5-(3)H]glucose over a 2h period) was decreased in islets from starved mice at all glucose concentrations up to approx. 55mm. At still higher glucose concentrations up to approx. 100mm, there was no difference between the fed and starved state, suggesting that the K(m) value for the rate-limiting glucose phosphorylation had been increased (approx. twofold) by starvation. Preparation of islets omitting substrates (glucose, pyruvate, fumarate and glutamate) from the medium during collagenase treatment lowered the glucose utilization measured subsequently at 16.7mm-glucose by 38 and 30% in islets from fed and starved mice respectively. Also the 2h lactate output by the islets at 16.7mm extracellular glucose was diminished by starvation. Incorporation of glucose into glycogen was extremely low, but the rate of incorporation was more than doubled by starvation. 5. After incubation for 30min at 16.7mm-glucose the content of glucose 6-phosphate was unchanged by starvation, that of ATP was increased and the concentration of (fructose 1,6-diphosphate plus triose phosphates) was decreased. 6. Possible mechanisms behind the correlated impairment in insulin secretion and islet glucose metabolism during starvation are discussed.
Scanning, Filtering and Prediction for Random Fields Corrupted by Gaussian Noise

We consider the problem of sequential decision making on random fields corrupted by Additive White Gaussian Noise (AWGN). In particular, we first consider the problem of sequentially filtering an AWGN-corrupted random field. In this scenario, the sequential filter may be given the freedom to choose the path over which it traverses the random field (e.g., noisy image), thus it is natural to ask what is the best achievable performance and how far is the performance of widely used scanning methods from the optimum. We formally define the problem of scanning and filtering, derive a bound on the best achievable performance and quantify the excess loss occurring when non-optimal scanners are used, compared to optimal scanning and filtering. We then discuss the problem of sequential scanning and prediction of noisy random fields. This setting is a natural model for applications such as restoration and coding of noisy images. In this scenario, using predictive coding methods on the noisy image results in both enhancement and compression of the input image, as one expects that the prediction error consists mainly of the noise signal. We formally define the problem of sequential prediction in a noisy array and compute the optimal performance in terms of the clean scandictability defined by Merhav and Weissman.
Access to orphan drugs despite poor quality of clinical evidence.

AIM We analysed the Belgian reimbursement decisions of orphan drugs as compared with those of innovative drugs for more common but equally severe diseases, with special emphasis on the quality of clinical evidence. METHODS Using the National Health Insurance Agency administrative database, we evaluated all submitted orphan drug files between 2002 and 2007. A quality analysis of the clinical evidence in the orphan reimbursement files was performed. The evaluation reports of the French 'Haute Autorité de Santé', including the five-point scale parameter 'Service Médical Rendu (SMR), were examined to compare disease severity. Chi-squared tests (at P < 0.05 significance level) were used to compare the outcome of the reimbursement decisions between orphan and non-orphan innovative medicines. RESULTS Twenty-five files of orphan drugs and 117 files of non-orphan drugs were evaluated. Twenty-two of 25 (88%) submissions of orphan drugs were granted reimbursement as opposed to 74 of the 117 (63%) non-orphan innovative medicines (P= 0.02). Only 52% of the 25 orphan drug files included a randomized controlled trial as opposed to 84% in a random control sample of 25 non-orphan innovative submissions (P < 0.01). The duration of drug exposure was in most cases far too short in relation to the natural history of the disease. CONCLUSIONS Orphan drug designation predicts reimbursement despite poor quality of clinical evidence. The evidence gap at market authorization should be reduced by post-marketing programmes, in which the centralized regulatory and the local reimbursement authorities collaborate in an efficient way across the European Union member states.
Generation and Function of Reactive Oxygen Species in Dendritic Cells During Antigen Presentation 1

Although reactive oxygen species (ROS) have long been considered to play pathogenic roles in various disorders, this classic view is now being challenged by the recent discovery of their physiological roles in cellular signaling. To determine the immunological consequence of pharmacological disruption of endogenous redox regulation, we used a selenium-containing antioxidant compound ebselen known to modulate both thioredoxin and glutaredoxin pathways. Ebselen at 5–20 μM inhibited Con A-induced proliferation and cytokine production by the HDK-1 T cell line as well as the LPS-triggered cytokine production by XS52 dendritic cell (DC) line. Working with the in vitro-reconstituted Ag presentation system composed of bone marrow-derived DC, CD4+ T cells purified from DO11.10 TCR-transgenic mice and OVA peptide (serving as Ag), we observed that 1) both T cells and DC elevate intracellular oxidation states upon Ag-specific interaction; 2) ebselen significantly inhibits ROS production in both populations; and 3) ebselen at 5–20 μM inhibits DC-induced proliferation and cytokine production by T cells as well as T cell-induced cytokine production by DC. Thus, Ag-specific, bidirectional DC-T cell communication can be blocked by interfering with the redox regulation pathways. Allergic contact hypersensitivity responses in BALB/c mice to oxazolone, but not irritant contact hypersensitivity responses to croton oil, were suppressed significantly by postchallenge treatment with oral administrations of ebselen (100 mg/kg per day). These results provide both conceptual and technical frameworks for studying ROS-dependent regulation of DC-T cell communication during Ag presentation and for testing the potential utility of antioxidants for the treatment of immunological disease.
ORGANIZATIONAL CULTURE AND THE USE OF INFLUENCE TACTICS BY MANAGERS

This study investigates the relationships between influence tactics of managers and organizational culture. Organizational members filled out questionnaires measuring four cultural values orientations (support, goals, innovation, rules), and nine influence tactics (consultation, ingratiation, inspirational appeals, rational persuasion, legitimating, pressure, exchange, personal appeals, coalition). Four hypotheses on the relationship between cultural orientation and use of influence tactics were tested and received mixed support. In all organizations, people try to influence each other. It is an explicit task of managers to exert intentional influence over their subordinates. Several specific types of behavior are used to exercise influence. What type will be used, and why? The present study investigates the relationship between influence behavior and organizational culture.