Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning curve associated with VATS lobectomy.

The first VATS lobectomy was performed in 1991 (1). Since then the implementation of VATS lobectomy has been rather slow. Data from the STS database shows a 32% rate of VATS lobectomies in 2006 (2). But it is only the best academic units that report to the STS database. This percentage is hence probably not representative for all the thoracic units in the USA. The implementation in Europe has been even slower than in the USA. But in the past years interest is rising, and in a recent report from The Society for Cardiothoracic Surgery in Great Britain and Ireland, the percentage of lobectomies performed by VATS has increased from 7% to 14% in just one year (2010). The slow adoption despite the obvious advantages is considered by many to be due to a demanding learning curve. The procedure is considered technically demanding and has the risk of uncontrollable bleeding. The introduction of VATS lobectomies in the surgical community was performed by self taught surgeons experienced in open surgery. The approaches varied from anterior, inferior to posterior, using 2-5 ports (3-6). These surgeons were pioneers and in case of intraoperative difficulties, conversion was their only option. The conversion rate was in many cases rather high (6). In Figure 1, the conversion rate and number of VATS lobectomies in Copenhagen between 1999 and 2011 is illustrated. The conversion rate declines with experience and number of cases per year. In the centres of the pioneers, the next generation learned the technique under guided supervision. The conditions for those surgeons’ learning curves were better due to the possibility of learning under supervision by an experienced VATS surgeon and a better possibility for selecting cases suitable for a training surgeon. Furthermore the surgical outcome was very satisfactory with low conversion and complication rates (7,8). Figure 1 Number of VATS lobectomies performed in Copenhagen 1999 to 2011 and conversions in % Since the introduction of VATS lobectomy in 1991, there has been a substantial improvement in the image quality. The introduction of firstly the digital thoracoscopes and later high definition (HD), has made precise dissection close to major vessels possible. Furthermore, several companies have designed curved instruments tailored to VATS surgery and a continuous improvement in these instruments have made it easier to perform and learn the technique. The quality of staplers has also improved significantly resulting in less air leak and fewer bronchial leaks.
Structural modulation in the orbitally induced Peierls state of MgTi2O4

The structural properties associated with the orbitally induced Peierls transition in MgTi2O4 are characterized by in situ cooling TEM observations. A distinctive structural modulation with the wavevector of q1 = 1/4 (0, 0, 4) has been well demonstrated below a critical temperature of about 260 K for MgTi2O4. Systematic analysis demonstrates that this structural modulation can be well explained by an orbital order existing in the low-temperature insulating phase. It is also noted that the nonstoichiometric feature commonly appearing in the present system could yield visible changes in both physical and structural properties. A low-temperature study of the microstructure of Mg[Ti1.9Mg0. 1]O4 reveals that a little substitution of Mg2+ for Ti3+ ions on the octahedral sites can disrupt the long-range order of the t2g orbitals, resulting in complex tweed structures in the superstructure phase.
Monoclonal antibody to intermediate filament antigen cross-reacts with higher plant cells

The monoclonal antibody (anti-IFA) raised (Pruss et al., 1981, Cell 27:419-428) against an intermediate filament antigen, which is widespread throughout phylogeny, has been shown here to cross-react with higher plants. On immunoblotting, anti-IFA cross-reacted with proteins in homogenates of carrot suspension cells and of meristematic cells from onion root tips. A 50-kD cross-reactive protein was enriched in a fraction that consisted of detergent-insoluble bundles of 7-nm fibrils from carrot protoplasts (Powell et al., 1982, J. Cell Sci. 56:319-335). By use of indirect immunofluorescence, anti-IFA stained formaldehyde-fixed onion meristematic cells and carrot protoplasts in patterns approximating those obtained with monoclonal anti-tubulins. That anti-IFA was not recognizing plant tubulins was established by use of immunoblots of two-dimensional gels on which the proteins that comprised isolated fibrillar bundles and taxol-purified carrot tubulins had been separated. The two groups of proteins had different positional coordinates: anti-IFA recognized the fibrillar bundle proteins, and anti-tubulins recognized plant microtubule proteins with no cross- reaction to the heterologous proteins. Likewise, formaldehyde-fixed taxol microtubules from carrot cells could be stained with anti-tubulin but not with anti-IFA. It is concluded that an epitope common to intermediate filaments from animals co-distributes with microtubules in higher plant cells.
Morphological alterations of Vero cell exposed to coplanar PCB 126 and noncoplanar PCB 153

Polychlorinated biphenyls (PCBs) are widespread, persistent environmental contaminants that display a complex spectrum of toxicological properties. Exposure to PCBs has been associated with morphological anomalies in cell cultures. However, most mechanistic studies of PCBs' toxic activity have been focused on coplanar congeners. It is of importance to determine whether PCB treatment would influence cell configuration and whether these changes would depend on the structural characteristics of PCBs. In this study, we investigated cell morphological alteration in Vero cell cultures after exposure to coplanar PCB 126 and noncoplanar PCB 153. The survival of Vero cells was measured through the MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) test. Cytotoxicity results suggested that PCB congeners had a toxic, antiproliferative effect on Vero cells. Morphological studies described structural modifications and provided evidence that apoptosis might be the main cell death pathway in PCB 153‐treated cells. The comparison between PCB 126 and PCB 153 indicated that the cell death mechanisms involved in coplanar or noncoplanar PCB congener exposure were different in Vero cells. © 2010 Wiley Periodicals, Inc. Environ Toxicol, 2012.
The Epidemiology and Geographic Distribution of Nontuberculous Mycobacteria Clinical Isolates from Sputum Samples in the Eastern Region of China

Background Nontuberculous mycobacteria (NTM) have been reported to be increasing worldwide and its geographic distribution differs by region. The aim of this study was to describe the epidemiology and distribution of NTM in the eastern part of China. Methods Sputum samples were collected from 30 surveillance sites for tuberculosis drug resistance test from May 1, 2008 to December 31, 2008. Identification was performed using a biochemical test, multiplex PCR and GenoType Mycobacterium CM/AS assay. Results A total of 1779 smear positive clinical isolates were obtained, of which 60 (3.37%) were NTM. Five species/complex of NTM were identified; M. intracellulare was the predominated species (68.33%), followed by M. abscessus-M. immunogenum (13.33%), Mycobacterium spec. (10.00%), M. Kansasii (6.67%) and M. peregrinum-M. alvei-M. septicum (1.67%). Conclusion M. intracellulare was the main species of NTM in the eastern part of China and clinical physicians should pay more attention to NTM induced pulmonary disease.
Expression of four phenobarbital-inducible cytochrome P-450s in liver, kidney, and lung of rats.

Specific antibodies were prepared against cytochromes P450 PB-1, PB-2, PB-4, and PB-5 purified from hepatic microsomes of male rats treated with phenobarbital. With these antibodies, the levels of these four cytochrome P450s in hepatic, renal, and pulmonary microsomes of male rats that were untreated, treated with phenobarbital, or treated with 3-methylcholanthrene were examined. P450 PB-1 and PB-2 were present in moderate amounts in hepatic microsomes of untreated male rats and were induced 2- to 3-fold with phenobarbital. Also, the expression of these forms was suppressed by 3-methylcholanthrene. These forms were not detected in the renal or pulmonary microsomes of untreated rats or rats treated with phenobarbital or 3-methylcholanthrene. P450 PB-4 and PB-5 were found in the hepatic microsomes of untreated male rats at a low level but were induced with phenobarbital more than 50-fold. P450 PB-4 and PB-5 were not detected in renal microsomes; only P450 PB-4 or a closely related form was present in the pulmonary microsomes of untreated male rats, and its level was not changed by phenobarbital treatment. The constitutive presence of P450 PB-4 in pulmonary microsomes was confirmed by the investigation of testosterone metabolism. Purified P450 PB-4 had high testosterone 16 alpha- and 16 beta-hydroxylation activity in a reconstituted system. The testosterone 16 beta-hydroxylation activity of hepatic microsomes was induced with phenobarbital, and more than 90% of the testosterone 16 beta-hydroxylation activity of hepatic microsomes from rats treated with phenobarbital was inhibited by anti-P450 PB-4 antibody. (ABSTRACT TRUNCATED AT 250 WORDS)
Scanning electron microscopy of the rat exocrine pancreas.

The three-dimensional architecture of the rat exocrine pancreas was studied by scanning electron microscopy (SEM) with the HCl digestion method. The treatment with HCl effectively removed connective tissue elements enclosing the ducts and the acini. Thus their shapes and relations were clearly revealed under the SEM. Furthermore fine surface features of the acinar or ductal cells were also demonstrated. Although recent studies have suggested that the pancreas might be reticular in architecture due to anastomoses between adjacent ducts or acini, the present investigation confirmed that rat pancreas is a compound acinar (alveolar) gland. Excretory ducts extended into interlobular spaces, branching dichotomously. Intercalated ducts, which showed an almost constant thickness, issued directly from the excretory ducts, entered the pancreatic lobuli, and branched several times to connect with numerous acini of varying size and shape. Basal surfaces of the excretory ducts showed conspicuous reticular undulation, while those of the intercalated ducts were smooth except for some areas with fine unevenness near the epithelial cell boundaries. It remains to be elucidated whether these basal structures of the intercalated ducts are involved in their assumed function, i.e., the secretion of water and bicarbonate in pancreatic juice. The acinar lumen was a narrow secretory canaliculus covered with finger-like microvilli. Intercellular canaliculi branched from the central canaliculus, taking a straight course toward the acinar cell base, and ended blindly. Some canaliculi extended to the close vicinity of the basement membrane, providing a locus minor is resistantiae for the leakage of pancreatic enzymes into blood. The SEM findings on the canalicular system were confirmed by light microscopic observation of the pancreatic excretory passages stained by the rapid Golgi method, and by three-dimensional reconstruction of the pancreatic acini from serial semithin sections.
Achievement Motivation Factors and Students' College Outcomes

The present study develops new measures of students' achievement motivation and examines the relationships between these measures and indicators of students' behavioral and college outcomes. Analysis yields moderate positive association of most aspects of achievement motivation with college outcomes. These relationships are quite strong for students' accomplishment and grades and weaker for commitment, assessment, and involvement. The best correlates of behavioral and college outcomes are persistence, locus of control, and action orientation.
Can Fundamental Movement Skill Mastery Be Increased via a Six Week Physical Activity Intervention to Have Positive Effects on Physical Activity and Physical Self-Perception?

Background: Previous research has suggested a positive relationship between fundamental movement skills (FMS) mastery and physical activity (PA) level. Research conducted on interventions to improve FMS mastery is equivocal and further research is needed. Methods: An intervention group of 82 children (35 boys and 47 girls) and a control group of 83 children (42 boys and 41 girls) were recruited from Years 4 and 5 (mean age ± SD = 8.3 ± 0.4 years) of two schools in Central England. The intervention included a combination of circuits and dancing to music. Pre and post intervention tests were conducted. Tests included: subjective assessment of eight FMS; objective measurement of two FMS; four day pedometer step count recording; height and mass for Body Mass Index (BMI); and the completion of Harter et al.’s (1982) self-perception questionnaire. Results: Following a two (pre to post) by two (intervention and control group) mixed-model ANOVA it was highlighted that the intervention group improved mastery in all eight FMS, and increased both daily steps and physical self-perception. Conclusions: It can be concluded that focussing one Physical Education (PE) lesson per week on the development of FMS has had a positive benefit on FMS, PA level and physical self-perception for the children in this study.
Second-Language Fluency Predicts Native Language Stroop Effects: Evidence from Spanish–English Bilinguals

Abstract Studies have shown reduced Stroop interference in bilinguals compared to monolinguals defined dichotomously, but no study has explored how varying degrees of second language fluency, might affect linguistic inhibitory control in the first language. We examined effects of relative English fluency on the ability to inhibit the automatic reading response on the Golden version of the Stroop Test administered in Spanish. Participants were 141 (49% male) adult native Spanish speakers from the U.S.–Mexico border region (education range = 8–20 and age range = 20–63). A language dominance index was calculated as the ratio of English words to total words produced in both languages using the Controlled Oral Word Association Test with letters PMR in Spanish and FAS in English. Greater degree of English fluency as measured by the dominance index predicted better speed on the Stroop incongruent trial independent of education effects. On the other hand, neither the dominance index nor education predicted performance on the word reading and color-naming trials. These results suggest an advantage in inhibitory control among those with greater second-language ability. (JINS, 2014, 20, 342–348)
Emiratii high school students’ understandings of stoichiometry and the influence of metacognition on their understanding

The aim of this study is to investigate Emiratii high school students’ understandings of stoichiometry, their use of metacognitive strategies, and the influence of students’ use of metacognitive strategies on their understandings of stoichiometry. Two instruments were used in this study, the first to measure students’ understandings of stoichiometry and the second to measure students’ use of metacognitive strategies. One hundred and sixty‐two 11th grade students participated in this study, 80 boys and 82 girls. The results showed that students’ understanding of stoichiometry was low and students used five metacognitive strategies: awareness of cognition, planning, monitoring and self‐checking, self‐appraisal and engagement in task. Planning was the most used strategy and could predict students’ success in displaying sound understanding of stoichiometry. The results also showed that students’ overall use of metacognitive strategies predicts their understanding of stoichiometry. The study argues that students should be taught how to use metacognitive strategies to improve their understanding of stoichiometry in particular and chemistry in general.
Low Vitamin D Levels are Associated With Need for Surgical Correction of Pediatric Fractures

Background: There is growing concern over the relationship between the severity of pediatric fractures and low vitamin D [25-hydroxyvitaminD (25(OH)D)] status. Objective: Compare 25(OH)D levels and lifestyle of children with fractures to nonfracture controls to determine if 25(OH)D levels are associated with fractures and if there is a 25(OH)D fragility fracture threshold. Methods: Pediatric fracture and nonfracture controls were included. Bone health survey and medical record data were analyzed. Fractures were categorized using the Abbreviated Injury Scale (AIS). AIS 3 fractures were identified as fractures that required surgical intervention. Univariate and multivariable ordinal regression analyses were performed to identify potential risk factors for increased fracture severity. Results: A total of 369 fracture patients and 662 nonfracture controls aged 18 years and younger were included. Both groups’ 25(OH)D levels were comparable. 25(OH)D was 27.5±8.9 in the fracture group compared with 27.4±9.1 ng/mL in nonfracture controls (P=0.914). AIS 3 fractures had lower 25(OH)D levels (24.6±9.3 ng/mL) versus AIS 1 and 2 (30.0±10.8 and 28.3±8.4, respectively, P=0.001). Univariate correlations for AIS severity were found with age (P=0.015) and outdoor playtime (P=0.042). Adjusted odds ratios for 25(OH)D levels <12 ng/mL was 55.4 (P=0.037), 25(OH)D between 12 and 20 ng/mL was 6.7 (P=0.039), 25(OH)D between 20 and 30 ng/mL was 2.8 (P=0.208), and 25(OH)D between 30 and 40 was 1.7 (P=0.518). Clinical Relevance: Occurrence of a pediatric fracture was not associated with 25(OH)D levels in our study. However, children with lower vitamin D levels were found to be at higher risk for more severe fractures. Early evidence suggests that the target serum level for 25(OH)D should be at least 40 ng/mL in patients less than 18 years of age as the relative risk of more severe fractures increased as 25(OH)D levels decreased <40 ng/mL. Level of Evidence: Level III.
Consumer Processing of Interior Service Environments

Visual appeal is an important consideration in the design of interior service environments because attractiveness influences consumer behavior. Employing both an experiment and a field study, we show that visual complexity reduces a service environment’s attractiveness. Furthermore, we find that the complexity-attractiveness relationship is mediated by processing fluency and its instantaneous affective companion, pleasure. Our findings provide novel insights into the underlying process mechanism involved in channeling the effect of visual complexity on attractiveness. Furthermore, both studies confirm that customers’ field dependence moderates the complexity-fluency relationship and that shopping motivation (i.e., hedonic vs. utilitarian shopping goals) moderates the fluency-pleasure relationship. Our findings suggest that it is generally better to reduce the complexity of interior service environments. To achieve this, service firms should reduce the number of objects in the environment, enhance the visual organization and symmetry of their arrangement, and use fewer colors, textures, and materials.
Determinants of International News Coverage in the U.S. Media

This article goes beyond describing media content and places it in a broader theoretical framework by examining some determinants that have been considered important in the study of international news flow. The article attempts to identify the factors that best differentiate those international events that are covered in the U.S. news media from events that are not. The dependent variable was media coverage of international events. Based on previous studies, seven variables were selected as predictors to separate the two groups: potential for social change, normative deviance, relevance to the United States, geographical distance, language affinity, press freedom, and economic system. A stepwise discriminant analysis was used to distinguish between the covered events and not-covered events, emphasizing identification of the most powerful discriminators. Results show that four variables contribute significantly to the discriminant function in distinguishing between covered events and not-covered events: normative deviance of an event, relevance to the United States, potential for social change, and geographical distance.
Distribution of serotonin-immunoreactive cell bodies and processes in the abdominal ganglion of mature Aplysia

Sensitization of the gill withdrawal reflex in Aplysia californica is an elementary form of learning, in part resulting from presynaptic facilitation of the LE mechanoreceptor neurons of the abdominal ganglion. It has previously been established that either application of serotonin or direct stimulation of a group of facilitatory neurons, the L29 cells of the abdominal ganglion, can simulate the effect of physiological stimulation in producing presynaptic facilitation. Because the evidence that serotonin serves as a facilitatory transmitter was indirect, we examined the distribution of serotonin- immunoreactive fibers and cell bodies in the abdominal ganglion in order to answer two questions: (1) do the sensory neurons receive serotonergic innervation and (2) are the L29 cells serotonergic? We observed two distinctive patterns of serotonergic innervation within the ganglion, sparse and dense. The sparse pattern is correlated with a serotonin-stimulated increase in cAMP in identified target cells, while the dense innervation is not. We found a sparse distribution of serotonin-immunoreactive fibers with varicosities close to both cell bodies and processes of identified LE sensory cells. It therefore is likely that the sensory neurons do receive serotonergic innervation. We also mapped the population of serotonergic neuronal cell bodies in the ganglion, and found five clusters of neurons. Cells in one of these clusters, the identified RB neurons, had previously been shown to synthesize serotonin from tryptophan and to contain the neurotransmitter in high concentration. Identified L29 facilitator cells marked by injection with Lucifer Yellow do not contain serotonin immunoreactivity and therefore evidently are not a source of serotonergic input onto sensory cells.
Writing Right: Enhancing Student Engagement and Performance in an Ecology Course.

This paper outlines the results of a collaborative effort between members of staff in the Departments of Life Sciences and Language, Linguistics and Philosophy, which involved the implementation of Writing Across the Curriculum strategies in an Ecology course. The lecturer for this course had expressed concerns regarding the poor quality of the laboratory reports presented and weak essays submitted by students. In order to enhance students' understanding of the content to be included in the report, and to improve expression of thought in writing, we agreed to 'treat' a sample of students selected from two laboratory groups by giving each group the other's lab report to read and to subsequently carry out the experiments described. Additionally a select group of students engaged in the planning, writing and revising of responses to past exam essay questions. Results showed that final exam grades for the ‘treated’ group and the writing group were significantly higher than their ‘non treated’ and ‘non writing’ counterparts. Feedback from students was generally positive. Implications and limitations are discussed.