Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical Activity and Public Health: A Recommendation From the Centers for Disease Control and Prevention and the American College of Sports Medicine

Objective. —To encourage increased participation in physical activity among Americans of all ages by issuing a public health recommendation on the types and amounts of physical activity needed for health promotion and disease prevention. Participants. —A planning committee of five scientists was established by the Centers for Disease Control and Prevention and the American College of Sports Medicine to organize a workshop. This committee selected 15 other workshop discussants on the basis of their research expertise in issues related to the health implications of physical activity. Several relevant professional or scientific organizations and federal agencies also were represented. Evidence. —The panel of experts reviewed the pertinent physiological, epidemiologic, and clinical evidence, including primary research articles and recent review articles. Consensus Process. —Major issues related to physical activity and health were outlined, and selected members of the expert panel drafted sections of the paper from this outline. A draft manuscript was prepared by the planning committee and circulated to the full panel in advance of the 2-day workshop. During the workshop, each section of the manuscript was reviewed by the expert panel. Primary attention was given to achieving group consensus concerning the recommended types and amounts of physical activity. A concise "public health message" was developed to express the recommendations of the panel. During the ensuing months, the consensus statement was further reviewed and revised and was formally endorsed by both the Centers for Disease Control and Prevention and the American College of Sports Medicine. Conclusion. —Every US adult should accumulate 30 minutes or more of moderate-intensity physical activity on most, preferably all, days of the week. ( JAMA . 1995;273:402-407)
Serological response to syphilis treatment in HIV-positive and HIV-negative patients attending sexually transmitted diseases clinics

Background: HIV-positive patients treated for syphilis may be at increased risk for serological failure. Objective: To compare follow-up serologies and serological responses to treatment between HIV-positive and HIV-negative patients attending two sexually transmitted disease (STD) clinics. Study design: Existing records were reviewed from HIV-positive patients who were diagnosed and treated for syphilis at the public STD clinics in Baltimore, Maryland, USA, between 1992 and 2000. Results of their serological follow-up were compared with those of HIV-negative clinic patients at the time of syphilis treatment. Failure was defined as lack of a fourfold drop in rapid plasma reagin (RPR) titre by 400 days after treatment or a fourfold increased titre between 30 and 400 days. Results: Of the 450 HIV-positive patients with syphilis, 288 (64%) did not have documented follow-up serologies and 129 (28.5%) met the inclusion criteria; 168 (17%) of 1000 known HIV-negative patients were similarly eligible. There were 22 failures in the HIV-positive group and 5 in the HIV-negative group (p<0.001). The median times to successful serological responses in both groups were 278 (95% confidence interval (CI) 209 to 350) and 126 (95% CI 108 to 157) days, respectively (p<0.001). A multivariate Cox’s proportional hazards model showed an increased risk of serological failure among the HIV-positive patients (hazards ratio 6.0, 95% CI 1.5 to 23.9; p = 0.01). Conclusion: HIV-positive patients treated for syphilis may be at higher risk of serological failure. Despite recommendations for more frequent serological follow-up, most patients did not have documentation of serological response after standard treatment for syphilis.
The Interplay Between Student Loans and Credit Card Debt : Implications for Default Behavior

Student loans and credit card loans represent important components of young households’ portfolios in the United States. While default rates on credit card debt are at historically low levels, default rates on student loans have increased significantly in recent years. There are important institutional differences between bankruptcy arrangements and default consequences in the two markets, which may affect default incentives. We theoretically and quantitatively analyze the interactions between these two forms of unsecured credit and the implications of their financial arrangements for default behavior of young U.S. households. We document important facts about the interaction between student loans, credit card debt, and default on both types of loans and build a general equilibrium model to explain the observed facts. We theoretically characterize the circumstances under which a household defaults on each of these loans and demonstrate that the institutional differences between the two credit markets make borrowers prefer to default on student loans rather than on credit card debt. Our quantitative analysis shows that the increase in student loan debt during recent years contributed about half of the increase in default rates, whereas worse labor outcomes for young borrowers during the Great Recession significantly amplified student loan default. At the same time, the credit card market contraction during this period helped reduce this effect. An income contingent repayment plan for student loans completely eliminates the default risk in the credit card market and induces important redistribution effects. This policy is beneficial (in a welfare improving sense) during the Great Recession, but not during normal times. JEL Codes: D91; I22; G19;
Perfusion CT in Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Long-Term Predictive Value of Baseline Perfusion CT Measurements

BACKGROUND AND PURPOSE: PCT studies hold short-term predictive value in patients treated with chemoradiotherapy. Our aim was to examine the long-term predictive value of baseline PCT studies for local tumor control and overall survival in SCCA of the upper aerodigestive tract treated with chemoradiotherapy. MATERIALS AND METHODS: Eighty-four patients with advanced SCCA underwent PCT followed by concomitant chemoradiation. The acquired perfusion maps represented BF, BV, MTT, and PS. Visual analysis of the parametric maps for identification of tumor perfusion patterns was conducted. ROC curves, t tests, and Kaplan-Meier survival curves were plotted for local disease control and overall survival. RESULTS: The median time of local tumor control was 24 months. The BF and PS values were significantly higher in patients who had no recurrence than in those with local failure (P ≤ .02). The BF and PS were predictive (P ≤ .0006) but BV and MTT held no significant predictive values for local tumor control. The patients with high BF and PS had a longer local tumor control than the patients with hypoperfused tumors (P = .0007). A visually detected BF-BV mismatch had a sensitivity/specificity of 63%/66% (P = .03) and 59%/69% (P = .03) for local tumor control and OS, respectively. Patients without mismatch lived significantly longer than patients with mismatch (P = .01). CONCLUSIONS: BF, PS, and mismatch of BF-BV are significant predictors of local tumor control after chemoradiation in SCCA of the upper aerodigestive tract.
Exploring Perceptions of the Potential of Agricultural Insurance for Crop Risks Management Among Smallholder Farmers in Northern Ghana

Smallholder farmers in Northern Ghana are exposed to multiple agricultural risks, which require various adaptation strategies to address. However, these strategies are only partially effective. Agricultural insurance has been promoted to assist smallholders in low-income countries to manage their key agricultural risks. The Ghanaian government and its collaborating partners introduced three agricultural insurance programs (AIPs) since 2009. In countries other than Ghana, some post-piloting evaluations of AIPs have revealed mixed outcomes, with some schemes resulting in unintended socio-ecological and maladaptive consequences. Despite these concerns, no study has explored the potential of agricultural insurance for smallholders’ crop risks management in Ghana. Thus, this research was undertaken to address this gap. It also investigates stakeholders’ perspectives of the potential of AIPs in promoting sustainable farming agricultural practices and climate change mitigation. I employed a convergent research design to address these issues using stratified, purposeful, and random sampling. Focus groups, informant interviews, and questionnaires were utilized to solicit responses. The resultant data and themes were analyzed using SPSS and Excel. This research revealed that agricultural risks, including those related and unrelated to weather and climate—have been adversely affecting smallholders, and have been addressed by farmers through food rationing, out-migration, and technology-based adaptation strategies. Some reported benefits of AIPs were the motivations to increase crop production, farm investments, and financial protection. This study provides scholarly, practical, regulatory, and policy-focused insight into agricultural insurance growth. My findings indicate that further attention and research are needed to building awareness about AIPs, the design of farmer-sensitive contracts, and their subsidization by government. I recommend future research focus on addressing INSURANCE FOR CROP RISKS MANAGEMENT v issues of upstream and downstream agro-risks management and on replicating this study in other geographical locations where smallholder farmers struggle to survive INSURANCE FOR CROP RISKS MANAGEMENT vi
Winning Isn't Everything: Corruption in Sumo Wrestling

Although the theoretical literature on corruption is well developed, empirical work in this area has lagged because it has proven difficult to isolate corrupt behavior in the data. In this paper, we look for evidence of corruption in an unlikely place: the highest echelons of Japanese sumo wrestling. This paper provides strong statistical evidence documenting match rigging in sumo wrestling. A non-linearity in the incentive structure of promotion leads to gains from trade between wrestlers on the margin for achieving a winning record and their opponents. We show that wrestlers win a disproportionate share of the matches when they are on the margin. Increased effort can not explain the findings. Winning on the bubble is more frequent when the two competitors have met often in the past. Success on the bubble tends to rise over the course of a wrestler's career, but declines in his last year, consistent with the game theoretic predictions. Wrestlers who are victorious when on the bubble lose more frequently than would be expected the next time they meet that opponent, suggesting that part of the payment for throwing a match is future payment in kind. Systematic differences across wrestling stables suggest that the stables play a role in facilitating the corruption. In times of increased media scrutiny, the match rigging disappears.
Information needs for the OR and PACU electronic medical record

Summary Objective: The amount of clinical information that anesthesia providers encounter creates an environment for information overload and medical error. In an effort to create more efficient OR and PACU EMR viewer platforms, we aimed to better understand the intraoperative and post-anesthesia clinical information needs among anesthesia providers. Materials and Methods: A web-based survey to evaluate 75 clinical data items was created and distributed to all anesthesia providers at our institution. Participants were asked to rate the importance of each data item in helping them make routine clinical decisions in the OR and PACU settings. Results: There were 107 survey responses with distribution throughout all clinical roles. 84% of the data items fell within the top 2 proportional quarters in the OR setting compared to only 65% in the PACU. Thirty of the 75 items (40%) received an absolutely necessary rating by more than half of the respondents for the OR setting as opposed to only 19 of the 75 items (25%) in the PACU. Only 1 item was rated by more than 20% of respondents as not needed in the OR compared to 20 data items (27%) in the PACU. Conclusion: Anesthesia providers demonstrate a larger need for EMR data to help guide clinical decision making in the OR as compared to the PACU. When creating EMR platforms for these settings it is important to understand and include data items providers deem the most clinically useful. Minimizing the less relevant data items helps prevent information overload and reduces the risk for medical error. Citation: Herasevich V, Ellsworth MA, Hebl JR, Brown MJ, Pickering BW. Information needs for the OR and PACU electronic medical record. Appl Clin Inf 2014; 5: 630–641 http://dx.doi. org/10.4338/ACI-2014-02-RA-0015
Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

The endothelium plays a critical role in the control of vasomotor tone by the release of vasoactive substances. Because endothelial injury or dysfunction is considered important very early in atherogenesis, we hypothesized that abnormal endothelial function precedes the angiographic detection of coronary atherosclerosis in the human coronary circulation. The coronary vasomotor responses to three different endothelium-mediated stimuli (intracoronary infusion of acetylcholine 10(-8) to 10(-6) M, increase in blood flow to induce flow-dependent dilation, and sympathetic stimulation by cold pressor testing) were assessed by quantitative angiography and subselective intracoronary Doppler flow velocity measurements within the left anterior descending coronary artery in 38 patients. All three stimuli elicited epicardial artery dilation in all 11 patients with smooth coronary arteries and absence of risk factors for coronary artery disease (group 1). All nine patients with smooth coronary arteries but with hypercholesterolemia (group 2) demonstrated a selective impairment in endothelial function with vasoconstriction (35 +/- 12.7% decrease in mean luminal area) in response to acetylcholine but showed a preserved flow-dependent dilation (15.5 +/- 4.4% increase in mean luminal area) and vasodilation in response to cold pressor testing (14.2 +/- 4.6% increase in mean luminal area). In all nine patients with an angiographically defined smooth coronary artery segment but with evidence of atherosclerosis elsewhere in the coronary system (group 3), both acetylcholine and cold pressor testing induced vasoconstriction (26.2 +/- 8.7% and 18.7 +/- 7.9% decrease in mean luminal area, respectively), whereas flow-dependent dilation was preserved (20.4 +/- 8.7% increase in mean luminal area). In the nine patients with angiographic evidence of wall irregularities (group 4), flow-dependent dilation was also abolished and vasoconstriction occurred in response to acetylcholine and cold pressor testing (34.5 +/- 10.7% and 19.9 +/- 6.3% decrease in mean luminal area, respectively). All coronary artery segments dilated in response to nitroglycerin, suggesting preserved function of vascular smooth muscle. Despite similar reductions in coronary vascular resistance in response to the smooth muscle relaxant papaverin, patients with hypercholesterolemia demonstrated a selective impairment of vasodilation of the resistance vasculature in response to acetylcholine (p less than 0.05 versus groups 1, 3, and 4). Thus, there is a progressive impairment of endothelial vasoactive functioning in coronary arteries of patients with different early stages of atherosclerosis, beginning with a selective endothelial dysfunction in angiographically defined normal arteries in patients with hypercholesterolemia and progressively worsening to a complete loss of endothelium-mediated vasodilation in angiographically defined atherosclerotic coronary arteries. (ABSTRACT TRUNCATED AT 400 WORDS)
More Happiness for Young People and Less for Mature Adults

Are Americans happier, or less happy, than they used to be? The answer may depend on life stage. We examined indicators of subjective well-being (SWB) in four nationally representative samples of U.S. adolescents (aged 13–18 years, n = 1.27 million) and adults (aged 18–96 years, n = 54,172). Recent adolescents reported greater happiness and life satisfaction than their predecessors, and adults over age 30 were less happy in recent years. Among adults, the previously established positive correlation between age and happiness has dwindled, disappearing by the early 2010s. Mixed-effects analyses primarily demonstrated time period rather than generational effects. The effect of time period on SWB is about d = |. 13| in most age groups, about the size of reported links between SWB and objective health, marital status, being a parent, and volunteering.
Active Feature Models

In this paper active feature models are proposed. They utilize local texture features and a statistical shape model for the reliable localization of landmarks in images. They are related to active appearance models, but instead of modelling the entire texture of an object they represent image texture by means of local descriptors. The approach has advantages with complex image data like anatomical structures that exhibit high texture variation with limited relevance for the recognition of the object location. Experimental results and the comparison to AAMs on different data sets indicate that active feature models can improve search speed and result accuracy, considerably
Successful Decoding of Famous Faces in the Fusiform Face Area

What are the neural mechanisms of face recognition? It is believed that the network of face-selective areas, which spans the occipital, temporal, and frontal cortices, is important in face recognition. A number of previous studies indeed reported that face identity could be discriminated based on patterns of multivoxel activity in the fusiform face area and the anterior temporal lobe. However, given the difficulty in localizing the face-selective area in the anterior temporal lobe, its role in face recognition is still unknown. Furthermore, previous studies limited their analysis to occipito-temporal regions without testing identity decoding in more anterior face-selective regions, such as the amygdala and prefrontal cortex. In the current high-resolution functional Magnetic Resonance Imaging study, we systematically examined the decoding of the identity of famous faces in the temporo-frontal network of face-selective and adjacent non-face-selective regions. A special focus has been put on the face-area in the anterior temporal lobe, which was reliably localized using an optimized scanning protocol. We found that face-identity could be discriminated above chance level only in the fusiform face area. Our results corroborate the role of the fusiform face area in face recognition. Future studies are needed to further explore the role of the more recently discovered anterior face-selective areas in face recognition.
A New Map Stitching Method for Anchor-free Localization in Wireless Sensor Networks

The map stitching is a type of localization algorithm in which the network is divided into small overlapping subregions, each of which creates a local map, and then, the local maps are stitched together to form a single global map. Although there are several methods of constructing local maps, every existing algorithms uses the same method for stitching two maps, called the absolute orientation method. In this paper, we extend the absolute orientation method so that it can handle every available distance constraints between two maps. We experimentally studied the performance of our proposing method under various settings. The results show that our method achieves a significant performance improvement upon the existing method.
Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: Implications for myocardium regeneration

The concept of tissue-restricted differentiation of postnatal stem cells has been challenged by recent evidence showing pluripotency for hematopoietic, mesenchymal, and neural stem cells. Furthermore, rare but well documented examples exist of already differentiated cells in developing mammals that change fate and trans-differentiate into another cell type. Here, we report that endothelial cells, either freshly isolated from embryonic vessels or established as homogenous cells in culture, differentiate into beating cardiomyocytes and express cardiac markers when cocultured with neonatal rat cardiomyocytes or when injected into postischemic adult mouse heart. Human umbilical vein endothelial cells also differentiate into cardiomyocytes under similar experimental conditions and transiently coexpress von Willebrand factor and sarcomeric myosin. In contrast, neural stem cells, which efficiently differentiate into skeletal muscle, differentiate into cardiomyocytes at a low rate. Fibroblast growth factor 2 and bone morphogenetic protein 4, which activate cardiac differentiation in embryonic cells, do not activate cardiogenesis in endothelial cells or stimulate trans-differentiation in coculture, suggesting that different signaling molecules are responsible for cardiac induction during embryogenesis and in successive periods of development. The fact that endothelial cells can generate cardiomyocytes sheds additional light on the plasticity of endothelial cells during development and opens perspectives for cell autologous replacement therapies.
Promoted Combustion of Nine Structural Metals in High-Pressure Gaseous Oxygen; A Comparison of Ranking Methods

Nine structural metals were evaluated for relative nonflammability, in a high pressure oxygen environment. The metals studied were: 316, 321, 440C and 17-4 PH stainless steels (SS), Inconel 600, Inconel 718, Waspaloy, Monel 400, and Aluminum 2219. A comparison is made between four methods which have been used to provide a relative flammability ranking of metals. A new relative ranking method is presented. Limitations of the ranking methods are assessed by investigating the effects of changes in test pressure, sample diameter, type of promoter, and sample configuration. Ranking methods which apply velocity as the primary ranking criterion are found to be limited by diameter effects. Methods which apply extinguishing pressure as the ranking criterion are found to be non-selective for metals with similar flammabilities. An overall ranking in agreement with all methods considered, for the metals described in this report, over a range of pressures and diameters, in order of combustion resistance, is: 1) Monel 400; 2) Inconel 600; 3) 316 SS, Waspaloy, Inconel 718, 17-4 PH SS, 440C SS, 321 SS; and 4) Aluminum 2219. Distinction is possible for metals in the third position; however, the relative ranking depends on the method chosen.
Antidrug Antibody Assay Validation: Industry Survey Results

Immunogenicity of biopharmaceutical products has attracted considerable attention from the industrial, academia, and regulatory organizations. Many methods exist to detect and characterize level of antidrug antibody response in patients. Still, additional work is required to harmonize various approaches used throughout the industry. This review presents results of a survey sponsored by the American Association of Pharmaceutical Scientists that was designed to collect relevant information and to understand various methods used throughout the bioanalytical field for the detection and evaluation of antidrug antibody responses.