Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparing the effect of high pressure and thermal processing on physico-chemical properties of broccoli puree and Listeria spp.

Broccoli is one of the most popular Brassica vegetables used as puree. In order to extend shelf life and quality of various vegetable purees, thermal treatment is applied. Thermal treatments have many advantages besides their requirement for microbiological risks assessment. In the present study, the effect of equivalent high pressure and thermal pasteurization processes on some quality related properties of broccoli puree were investigated. Viscosity, colour, values, sensory properties and inactivation of Listeria innocua were studied. Results indicate that thermal processes had a significant effect on quality properties of broccoli puree. A significant decrease in a* and L* values, viscosity and overall acceptability was found after thermal processes. High pressure processing at 600 MPa (holding time: 10 min/initial temperature: 10 °C) improved the colour and viscosity compared to severe HP pasteurization and thermal pasteurization processes (p>0.05). Both HP and thermal pasteurization resulted in inactivation of the inoculated Listeria innocua to a level below the detection
Testing linearity in term structures

This article uses robust nonparametric techniques to investigate both crosssectional and dynamic properties of affine models, a popular framework to analyse Term Structures (TSs) of interest rates. The analysis shows the strong nonlinearity in the relationship of yields to the US and UK short rate. The nonlinear pattern is concave in the state variable, and increasing with respect to the maturity, for both countries. Linear and nonlinear specifications are then compared by means of a formal statistical criterion, the Generalized Likelihood-Ratio (GLR) test statistics, which confirms evidence against the linear specification.
Optical multiband observations of BL Lacertae during the outburst of 2005

The aim of our observations is to investigate the intranight variability properties and the spectral variability of BL Lacertae. 799 optical multiband observations were intensively made with the Beijing‐Arizona‐Taiwan‐Connecticut (BATC) 60/90 cm Schmidt telescope during the outburst composed of two subsequent flares in 2005. The second flare, whose rising phase lasted at least 44 d, was observed with amplitudes of more than 1.1 mag in three BATC optical bands. In general, on intranight time-scale the amplitude of variability and the variation rate are larger at the shorter wavelength, and the variation rate is comparable in the rising and decaying phases within each band. A possible time-lag between the light curves in bands e and m, around 11.6 min, was obtained. Based on the analysis of the colour index variation with the source brightness, the variability of BL Lacertae can be interpreted as having two components: a ‘strongly chromatic’ intranight component and a ‘mildly chromatic’ internight component, which may be the results of both intrinsic physical mechanism and geometric effects.
International Journal of General Medicine Dovepress Dendritic Cell Populations in Patients with Self-reported Food Hypersensitivity

Self-reported hypersensitivity to food is a common condition and many of these patients have indications of intestinal immune activation. Dendritic cells (DCs) are recognized as the most potent antigen-presenting cells involved in both initiating immune responses and maintaining tolerance. The aims of this study were to evaluate the DC populations with their phenotype and T cell stimulatory capacity in patients with food hypersensitivity and to study its relationship with atopic disease. Blood samples from 10 patients with self-reported food hypersensitivity, divided into atopic and nonatopic subgroups, and 10 gender-and age-matched healthy controls were analyzed by flow cytometry using the Miltenyi Blood Dendritic cells kit. Monocyte-derived DCs (moDCs) were evaluated concerning their phenotype and T cell stimula-tory capacity. DC populations and cell surface markers were not significantly different between patients and healthy controls, but moDCs from atopic patients expressed significantly more CD38 compared to moDCs from nonatopic patients. Moreover, lipopolysaccharide stimulated moDCs from atopic patients produced significantly more interleukin-10 compared to nonatopic patients. CD38 expression was correlated to total serum immunoglobulin E levels. These findings support the notion of immune activation in some patients with self-reported food hypersensitivity. They need to be confirmed in a larger cohort.
Recommendation of Job Offers Using Random Forests and Support Vector Machines

The challenge of automatically recommending job offers to appropriate job seekers is a topic that has attracted many research effort during the last times. However, it is generally assumed that there is a need of more user-friendly filtering methods so that the automated recommendation systems might be more widely used. We present here our research on two methods from the data analytics field being able to disseminate job offers to the right person at the right time, which are based on Random Forest and Support Vector Machines respectively. Both methods are used here to identify the actual attributes in which users are set when they are attracted to a job offer. Preliminary results in the context of automatic job recommendation suggest that these two methods seem to be promising.
Accurate Estimation of Effective Population Size in the Korean Dairy Cattle Based on Linkage Disequilibrium Corrected by Genomic Relationship Matrix

Linkage disequilibrium between markers or genetic variants underlying interesting traits affects many genomic methodologies. In many genomic methodologies, the effective population size (Ne) is important to assess the genetic diversity of animal populations. In this study, dairy cattle were genotyped using the Illumina BovineHD Genotyping BeadChips for over 777,000 SNPs located across all autosomes, mitochondria and sex chromosomes, and 70,000 autosomal SNPs were selected randomly for the final analysis. We characterized more accurate linkage disequilibrium in a sample of 96 dairy cattle producing milk in Korea. Estimated linkage disequilibrium was relatively high between closely linked markers (>0.6 at 10 kb) and decreased with increasing distance. Using formulae that related the expected linkage disequilibrium to Ne, and assuming a constant actual population size, Ne was estimated to be approximately 122 in this population. Historical Ne, calculated assuming linear population growth, was suggestive of a rapid increase Ne over the past 10 generations, and increased slowly thereafter. Additionally, we corrected the genomic relationship structure per chromosome in calculating r2 and estimated Ne. The observed Ne based on r2 corrected by genomics relationship structure can be rationalized using current knowledge of the history of the dairy cattle breeds producing milk in Korea.
Recurrent neural network language model adaptation for multi-genre broadcast speech recognition

Copyright © 2015 ISCA. Recurrent neural network language models (RNNLMs) have recently become increasingly popular for many applications including speech recognition. In previous research RNNLMs have normally been trained on well-matched in-domain data. The adaptation of RNNLMs remains an open research area to be explored. In this paper, genre and topic based RNNLMadaptation techniques are investigated for a multi-genre broadcast transcription task. A number of techniques including Probabilistic Latent Semantic Analysis, Latent Dirichlet Allocation and Hierarchical Dirichlet Processes are used to extract show level topic information. These were then used as additional input to the RNNLM during training, which can facilitate unsupervised test time adaptation. Experiments using a state-of-theart LVCSR system trained on 1000 hours of speech and more than 1 billion words of text showed adaptation could yield perplexity reductions of 8% relatively over the baseline RNNLM and small but consistent word error rate reductions.
Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

ABSTRACT Understanding how some HIV-infected cells resist the cytotoxicity of HIV replication is crucial to enabling HIV cure efforts. HIV killing of CD4 T cells that replicate HIV can involve HIV protease-mediated cleavage of procaspase 8 to generate a fragment (Casp8p41) that directly binds and activates the mitochondrial proapoptotic protein BAK. Here, we demonstrate that Casp8p41 also binds with nanomolar affinity to the antiapoptotic protein Bcl-2, which sequesters Casp8p41 and prevents apoptosis. Further, we show that central memory CD4 T cells (TCM) from HIV-infected individuals have heightened expression of BCL-2 relative to procaspase 8, possibly explaining the persistence of HIV-infected TCM despite generation of Casp8p41. Consistent with this hypothesis, the selective BCL-2 antagonist venetoclax induced minimal killing of uninfected CD4 T cells but markedly increased the death of CD4 T cells and diminished cell-associated HIV DNA when CD4 T cells from antiretroviral therapy (ART)-suppressed HIV patients were induced with αCD3/αCD28 to reactivate HIV ex vivo. Thus, priming CD4 T cells from ART suppressed HIV patients with a BCL-2 antagonist, followed by HIV reactivation, achieves reductions in cell-associated HIV DNA, whereas HIV reactivation alone does not. IMPORTANCE HIV infection is incurable due to a long-lived reservoir of HIV+ memory CD4 T cells, and no clinically relevant interventions have been identified that reduce the number of these HIV DNA-containing cells. Since postintegration HIV replication can result in HIV protease generation of Casp8p41, which activates BAK, causing infected CD4 T cell death, we sought to determine whether this occurs in memory CD4 T cells. Here, we demonstrate that memory CD4 T cells can generate Casp8p41 and yet are intrinsically resistant to death induced by diverse stimuli, including Casp8p41. Furthermore, BCL-2 expression is relatively increased in these cells and directly binds and inhibits Casp8p41's proapoptotic effects. Antagonizing BCL-2 with venetoclax derepresses this antagonism, resulting in death, preferentially in HIV DNA containing cells, since only these cells generate Casp8p41. Thus, BCL-2 antagonism is a clinically relevant intervention with the potential to reduce HIV reservoir size in patients.
Monkey Perirhinal Cortex is Critical for Visual Memory, but not for Visual Perception: Reexamination of the Behavioural Evidence from Monkeys

Overdependence on discrimination learning paradigms to assess the function of perirhinal cortex has complicated understanding of the cognitive role of this structure. Impairments in discrimination learning can result from at least two distinct causes: (a) failure to accurately apprehend and represent the relevant stimuli, or (b) failure to form and remember associations between stimulus representations and reward. Thus, the results of discrimination learning experiments do not readily differentiate deficits in perception from deficits in learning and memory. Here I describe studies that do dissociate learning and memory from perception and show that perirhinal cortex damage impairs learning and/or memory, but not perception. Reanalysis and reconsideration of other published data call into further question the hypothesis that the monkey perirhinal cortex plays a critical role in visual perception.
EEG Correlates of Preparatory Orienting, Contextual Updating, and Inhibition of Sensory Processing in Left Spatial Neglect

Studies with event-related potentials have highlighted deficits in the early phases of orienting to left visual targets in right-brain-damaged patients with left spatial neglect (N+). However, brain responses associated with preparatory orienting of attention, with target novelty and with the detection of a match/mismatch between expected and actual targets (contextual updating), have not been explored in N+. Here in a study in healthy humans and brain-damaged patients of both sexes we demonstrate that frontal activity that reflects supramodal mechanisms of attentional orienting (Anterior Directing Attention Negativity, ADAN) is entirely spared in N+. In contrast, posterior responses that mark the early phases of cued orienting (Early Directing Attention Negativity, EDAN) and the setting up of sensory facilitation over the visual cortex (Late Directing Attention Positivity, LDAP) are suppressed in N+. This uncoupling is associated with damage of parietal-frontal white matter. N+ also exhibit exaggerated novelty reaction to targets in the right side of space and reduced novelty reaction for those in the left side (P3a) together with impaired contextual updating (P3b) in the left space. Finally, we highlight a drop in the amplitude and latency of the P1 that over the left hemisphere signals the early blocking of sensory processing in the right space when targets occur in the left one: this identifies a new electrophysiological marker of the rightward attentional bias in N+. The heterogeneous effects and spatial biases produced by localized brain damage on the different phases of attentional processing indicate relevant functional independence among their underlying neural mechanisms and improve the understanding of the spatial neglect syndrome. SIGNIFICANCE STATEMENT Our investigation answers important questions: are the different components of preparatory orienting (EDAN, ADAN, LDAP) functionally independent in the healthy brain? Is preparatory orienting of attention spared in left spatial neglect? Does the sparing of preparatory orienting have an impact on deficits in reflexive orienting and in the assignment of behavioral relevance to the left space? We show that supramodal preparatory orienting in frontal areas is entirely spared in neglect patients though this does not counterbalance deficits in preparatory parietal-occipital activity, reflexive orienting, and contextual updating. This points at relevant functional dissociations among different components of attention and suggests that improving voluntary attention in N+ might be behaviorally ineffective unless associated with stimulations boosting the response of posterior parietal-occipital areas.
The familial basis of facial emotion recognition deficits in adolescents with conduct disorder and their unaffected relatives

Background There is accumulating evidence of impairments in facial emotion recognition in adolescents with conduct disorder (CD). However, the majority of studies in this area have only been able to demonstrate an association, rather than a causal link, between emotion recognition deficits and CD. To move closer towards understanding the causal pathways linking emotion recognition problems with CD, we studied emotion recognition in the unaffected first-degree relatives of CD probands, as well as those with a diagnosis of CD. Method Using a family-based design, we investigated facial emotion recognition in probands with CD (n = 43), their unaffected relatives (n = 21), and healthy controls (n = 38). We used the Emotion Hexagon task, an alternative forced-choice task using morphed facial expressions depicting the six primary emotions, to assess facial emotion recognition accuracy. Results Relative to controls, the CD group showed impaired recognition of anger, fear, happiness, sadness and surprise (all p < 0.005). Similar to probands with CD, unaffected relatives showed deficits in anger and happiness recognition relative to controls (all p < 0.008), with a trend toward a deficit in fear recognition. There were no significant differences in performance between the CD probands and the unaffected relatives following correction for multiple comparisons. Conclusions These results suggest that facial emotion recognition deficits are present in adolescents who are at increased familial risk for developing antisocial behaviour, as well as those who have already developed CD. Consequently, impaired emotion recognition appears to be a viable familial risk marker or candidate endophenotype for CD.
De novo donor‐specific HLA antibodies after combined intestinal and vascularized composite allotransplantation — a retrospective study

Combining vascularized composite allotransplantation (VCA) with intestinal transplantation to achieve primary abdominal closure has become a feasible procedure. Besides facilitating closure, the abdominal wall can be used to monitor intestinal rejection. As the inclusion of a VCA raises the possibility of an enhanced alloimmune response, we investigated the incidence and clinical effect of de novo donor‐specific HLA antibodies (dnDSA) in a cohort of patients receiving an intestinal transplant with or without a VCA. The sequential clinical study includes 32 recipients of deceased donor intestinal and VCA transplants performed between 2008 and 2015; eight (25%) modified multivisceral transplants and 24 (75%) isolated small bowel transplants. A VCA was used in 18 (56.3%) cases. There were no episodes of intestinal rejection without VCA rejection. Fourteen patients (14 of 29; 48.3%) developed dnDSA. In the VCA group, fewer patients developed dnDSA; six of 16 (37.5%) VCA vs. eight of 13 (61.5%) non‐VCA. There was no statistically significant difference in one‐ and 3‐year overall graft survival stratified for the presence of dnDSA; P = 0.286. In the study, there is no evidence that the addition of a VCA increases the incidence of dnDSA formation compared to transplantation of the intestine alone.
Let the sunshine in? The effects of luminance on economic preferences, choice consistency and dominance violations

Weather, in particular the intensity and duration of sunshine (luminance), has been shown to significantly affect financial markets. Yet, because of the complexity of market interactions we do not know how human behavior is affected by luminance in a way that could inform theoretical choice models. In this paper, we use data from a field study using an incentive-compatible, decision task conducted daily over a period of two years and from the US Earth System Research Laboratory luminance sensor to investigate the impact of luminance on risk preferences, ambiguity preferences, choice consistency and dominance violations. We find that luminance levels affect all of these. Age and gender influence the strength of some of these effects.
Neuroimaging-based biomarkers for treatment selection in major depressive disorder

The use of neuroimaging approaches to identify likely treatment outcomes in patients with major depressive disorder is developing rapidly. Emerging work suggests that resting state pretreatment metabolic activity in the fronto-insular cortex may distinguish between patients likely to respond to psychotherapy or medication and may function as a treatment-selection biomarker. In contrast, high metabolic activity in the subgenual anterior cingulate cortex may be predictive of poor outcomes to both medication and psychotherapy, suggesting that nonstandard treatments may be pursued earlier in the treatment course. Although these findings will require replication before clinical adoption, they provide preliminary support for the concept that brain states can be measured and applied to the selection of a specific treatment most likely to be beneficial for an individual patient.
Three‐dimensional micro‐MRI analysis of cerebral artery development in mouse embryos

Vascular system development involves a complex, three‐dimensional branching process that is critical for normal embryogenesis. In the brain, the arterial systems appear to develop in a stereotyped fashion, but no detailed quantitative analyses of the mouse embryonic cerebral arteries have been described. In this study, a gadolinium‐based contrast perfusion method was developed to selectively enhance the cerebral arteries in fixed mouse embryos. Three‐dimensional magnetic resonance micro‐imaging (micro‐MRI) data were acquired simultaneously from multiple embryos staged between 10 and 17 days of gestation, and a variety of image analysis methods was used to extract and analyze the cerebral arterial patterns. The results show that the primary arterial branches in the mouse brain are very similar between individuals, with the patterns established early and growth occurring by extension of the segments, while maintaining the underlying vascular geometry. To investigate the utility of this method for mutant mouse phenotype analysis, contrast‐enhanced micro‐MRI data were acquired from Gli2‐/‐ mutant embryos and their wild‐type littermates, showing several previously unreported vascular phenotypes in Gli2−/− embryos, including the complete absence of the basilar artery. These results demonstrate that contrast‐enhanced micro‐MRI provides a powerful tool for analyzing vascular phenotypes in a variety of genetically engineered mice. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
Analyzing the Commitment of College Students Using a Brief, Contextualized Measure of Need Satisfaction From the Perspective of Self-Determination Theory

This study empirically confirmed the relationships between the degree to which students satisfied three basic needs (competence, relatedness, and autonomy) and the strength of their commitments to the university they attended and to obtaining a baccalaureate degree. A questionnaire was administered online to 1257 students at two 4-year universities. Regression analysis yielded statistically significant associations between the three needs and Institutional Commitment and Degree Commitment, explaining more than 20% of the variance in the latter two variables.
Laser Energy Effects on Optical Properties of Titanium Di-Oxide Prepared by Reactive Pulsed Laser Deposition

In this Work, Laser energy effects on optical and morphological properties of TiO2 thin film has been carried out using Reactive Pulsed Laser as a Deposition technique (RPLD). Q-switched Nd-YAG laser with ( λ=1.06µm, t =7nsec) and different energies have been used to ablate pure Titanium target and deposited thin films on glass substrates with constant substrate temperature of (343K). The optical properties of the films prepared include Optical transmit ion and absorption measurement, surface uniformity measurement and FTIR structure of these films. The results films show that high transparency reached to about (85-98) % can be achieved with TiO2 film which itself decreases sharply with the increasing of Laser energy while the optical band gap is (3.7-3.9) eV at optimum Laser energy in all results (800mJ), the FTIRstructure result at 800 mJ is the optimum and peaks absorption of TiO2 are (408.91, 439.77, 524.64) cm -1
DDX5 RNA Helicases: Emerging Roles in Viral Infection

Asp-Glu-Ala-Asp (DEAD)-box polypeptide 5 (DDX5), also called p68, is a prototypical member of the large ATP-dependent RNA helicases family and is known to participate in all aspects of RNA metabolism ranging from transcription to translation, RNA decay, and miRNA processing. The roles of DDX5 in cell cycle regulation, tumorigenesis, apoptosis, cancer development, adipogenesis, Wnt-β-catenin signaling, and viral infection have been established. Several RNA viruses have been reported to hijack DDX5 to facilitate various steps of their replication cycles. Furthermore, DDX5 can be bounded by the viral proteins of some viruses with unknown functions. Interestingly, an antiviral function of DDX5 has been reported during hepatitis B virus and myxoma virus infection. Thus, the precise roles of this apparently multifaceted protein remain largely obscure. Here, we provide a rapid and critical overview of the structure and functions of DDX5 with a particular emphasis on its role during virus infection.