Miracle-dz/UniFAR-FTUs huggingface dataset:
Lamotrigine use in pregnancy and risk of orofacial cleft and other congenital anomalies

Objective: To test previous signals of a risk of orofacial cleft (OC) and clubfoot with exposure to the antiepileptic lamotrigine, and to investigate risk of other congenital anomalies (CA). Methods: This was a population-based case–malformed control study based on 21 EUROCAT CA registries covering 10.1 million births (1995–2011), including births to 2005 in which the clubfoot signal was generated and a subsequent independent study population of 6.3 million births. A total of 226,806 babies with CA included livebirths, stillbirths, and terminations of pregnancy following prenatal diagnosis. First-trimester lamotrigine monotherapy exposure in OC cases and clubfoot cases was compared to other nonchromosomal CA (controls). Odds ratios (OR) were adjusted for registry. An exploratory analysis compared the proportion of each standard EUROCAT CA subgroup among all babies with nonchromosomal CA exposed to lamotrigine monotherapy with non-AED exposed pregnancies. Results: There were 147 lamotrigine monotherapy-exposed babies with nonchromosomal CA. For all OC, ORadj was 1.31 (95% confidence interval [CI] 0.73–2.33), isolated OC 1.45 (95% CI 0.80–2.63), isolated cleft palate 1.69 (95% CI 0.69–4.15). Overall ORadj for clubfoot was 1.83 (95% CI 1.01–3.31) and 1.43 (95% CI 0.66–3.08) in the independent study population. No other specific CA were significantly associated with lamotrigine monotherapy. Conclusions: The risk of OC was not significantly raised and we estimate the excess risk of OC to be less than 1 in every 550 exposed babies. We have not found strong independent evidence of a risk of clubfoot subsequent to our original signal. Our study cannot assess the general malformation risk among lamotrigine-exposed pregnancies.
Could whole-body cryotherapy (below −100°C) improve muscle recovery from muscle damage?

Muscle performance might be temporarily impaired by high-intensity exercise performed during a competition or training session. The attenuation in muscular strength may be transitory, lasting minutes, hours, or several days following training or competition (Barnett, 2006). Longer-lasting impairment in muscle strength accompanied by a reduction in range of motion, an increase in muscle proteins in the blood, an inflammatory response, muscle swelling, and delayed onset muscle soreness is referred to as exercise induced muscle damage (EIMD) (Clarkson and Hubal, 2002; Barnett, 2006; Paulsen et al., 2012). Different modalities have been used to improve recovery from a damaging bout of exercise (Barnett, 2006). Among the most common treatment approaches used to reestablish muscular function are active recovery, compression garments, massage, stretching, anti-inflammatory drugs, and cryotherapy (Cheung et al., 2003; Barnett, 2006; Bishop et al., 2008). A relatively novel modality of cryotherapy is whole-body cryotherapy (WBC), which consists of brief exposure (2–3 min) to extremely cold air (−100 to −195°C) in a temperature-controlled chamber or cryocabin (Banfi et al., 2010; Hausswirth et al., 2011; Fonda and Sarabon, 2013). Sessions of partial-body cryotherapy (PBC), in which the head is not exposed to cold, has also been used as a similar modality of WBC (Hausswirth et al., 2013). According to Hausswirth et al. (2013), WBC and PBC session decreased skin temperature, however, WBC induced a greater decrease compared to PBC. In addition, the tympanic temperature was reduced only after the WBC session. Moreover, parasympathetic tone stimulation was greater following the WBC session. Although WBC has been used since the end of the 1970s in the treatment of rheumatic diseases (Ksiezopolska-Pietrzak, 2000; Metzger et al., 2000; Rymaszewska et al., 2003), it has only recently been used with the purpose of hastening recovery from muscle damage by decreasing the inflammatory process linked to EIMD (Banfi et al., 2010). A logic model proposed by Costello et al. (2013) consisted of the physiological, neuromuscular, and perceptual effects following exposure to WBC which may interact to increase performance. However, a mechanistic model for how WBC may improve symptoms related to EIMD has to this point not been provided (Costello et al., 2013). Thus, the purpose of this manuscript was to briefly address a possible mechanism related to improved recovery from muscle damage by WBC.
Towards a Semantic Administrative Shell for Industry 4.0 Components

In the engineering and manufacturing domain, there is currently an atmosphere of departure to a new era of digitized production. In different regions, initiatives in these directions are known under different names, such as industrie du futur in France, industrial internet in the US or Industrie 4.0 in Germany. While the vision of digitizing production and manufacturing gained much traction lately, it is still relatively unclear how this vision can actually be implemented with concrete standards and technologies. Within the German Industry 4.0 initiative, the concept of an Administrative Shell was devised to respond to these requirements. The Administrative Shell is planned to provide a digital representation of all information being available about and from an object which can be a hardware system or a software platform. In this paper, we present an approach to develop such a digital re presentation based on semantic knowledge representation formalisms such as RDF, RDF Schema and OWL. We present our concept of a Semantic I4.0 Component which addresses the communication and comprehension challenges in Industry 4.0 scenarios using semantic technologies. Our approach is illustrated with a concrete example showing its benefits in a real-world use case.
Rising Female Labour Force Participation and the Distribution of Family Income—the Swedish Experience

This paper analyses how rising labour force participation of marned women in Sweden during the 1970s affected the distribution of family income. We use the squared coefficient of variation and compare the dispersion of family (factor) income with the dispersion of marned men's income We find an equalizing effect of wives' income, in the sense that family income is more equal than husbands' income. Furthermore, the equalizing effect of female income was stronger in 1980 than in 1967, i.e. when female labour force participation had increased markedly. An examination of hours of work and determinants of wage rates suggests that the equalizing effects stem from wage rates rather than from hours of work. This effect holds in spite of very strong positive correlation between husbands' and wives' education.
Transmit power adaptation for multiuser OFDM systems

In this paper, we develop a transmit power adaptation method that maximizes the total data rate of multiuser orthogonal frequency division multiplexing (OFDM) systems in a downlink transmission. We generally formulate the data rate maximization problem by allowing that a subcarrier could be shared by multiple users. The transmit power adaptation scheme is derived by solving the maximization problem via two steps: subcarrier assignment for users and power allocation for subcarriers. We have found that the data rate of a multiuser OFDM system is maximized when each subcarrier is assigned to only one user with the best channel gain for that subcarrier and the transmit power is distributed over the subcarriers by the water-filling policy. In order to reduce the computational complexity in calculating water-filling level in the proposed transmit power adaptation method, we also propose a simple method where users with the best channel gain for each subcarrier are selected and then the transmit power is equally distributed among the subcarriers. Results show that the total data rate for the proposed transmit power adaptation methods significantly increases with the number of users owing to the multiuser diversity effects and is greater than that for the conventional frequency-division multiple access (FDMA)-like transmit power adaptation schemes. Furthermore, we have found that the total data rate of the multiuser OFDM system with the proposed transmit power adaptation methods becomes even higher than the capacity of the AWGN channel when the number of users is large enough.
User cooperation effects on firm's innovation outputs

We analyzed the effects of R&D cooperation with users and the intensity/continuity of such cooperation on firms’ innovation output—whether radical or incremental. We also examined the moderating effect of firm size on these relationships. Results show that cooperation with users favours the development of both radical and incremental product innovations. In addition, we found that the higher the intensity/continuity of the relationship with users, the more likely radical innovations are to develop when compared with incremental innovations. We note that the positive effect of cooperation on the development of innovation is especially significant for small firms. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.
A Probabilistic Approach for Estimating the Number of Bad Receivers in a Multicast Group with Application to Hybrid FEC/ARQ-based Reliable Wireless Multicast

When a wireless base station needs to transfer a data block to a large multicast group in a reliable way, a hybrid FEC/ARQbased protocol is usually the best solution. For a large multicast group, having each bad receiver send a NACK to the base station would result in a feedback implosion. In this paper we present an algorithm for estimating the number of bad receivers while limiting the number of NACKs. This algorithm analyzes the NACK transmission times, defines a likelihood function for them, and then uses the Newton-Raphson method to find the number of bad receivers for which this function is maximized. We then analyze the precision of the proposed algorithm, and provide tight upper and lower bounds to the estimation error. These bounds indicate a linear correlation between the estimation error and the number of NACKs. But even more important, they allow us to correct the precision of our estimation, and to bring the error very close to 0. To the best of our knowledge, our paper is the first to explicitly show the correlation between the number of NACKs sent by a group and the ability of the sender to estimate the size of this group precisely.
The Politics of No Child Left Behind: Will the Coalition Hold?

On January 8, 2002, President George W. Bush signed the No Child Left Behind Act (NCLB) into law. Surrounded by smiling members of the Democratic and Republican leadership, the President declared, “as of this hour, America’s schools will be on a new path of reform, and a new path of results” (Office of the White House Press Secretary, 2002). NCLB brought sweeping changes to the 37-year-old Elementary and Secondary Education Act (ESEA) and thrust the nation’s educators, schools, and school districts into a new world of federal educational leadership.
Commodity-Linked Bonds: A Potential Means for Less-Developed Countries to Raise Foreign Capital

The author suggests that commodity-linked bonds could provide a potential means for less-developed countries (LDCs) to raise money on the international capital markets, rather than through standard forms of financing. The issue of this type of bond could provide an opportunity for commodity-producing LDCs to hedge against fluctuations in their export earnings. The author's results show that the value of a commodity-linked bond increases as the price of the commodity indexed to the bond rises; this suggests that, if LDCs had issued debt contracts that were tied to their main export commodities, then their debt load would decline along with plummeting export prices (or export revenues). A simple portfolio rule derived by the author suggests that LDCs should issue more commodity-linked bonds than conventional debt if the variance of the portfolio is greater than twice the spread between the expected total return of the conventional debt and the commodity-linked bond. This rule supports the view that, if more of the LDCs' debt were issued in the form of commodity-linked bonds, then the debt-service payment of the LDCs would decline along with export prices (or export revenues), thus lightening their debt load.
Swimming training prevents alterations in acetylcholinesterase and butyrylcholinesterase activities in hypertensive rats.

BACKGROUND Cholinergic enzyme activities are altered in hypertension, reflecting a low-grade inflammation. Regular physical exercise exerts anti-inflammatory effects and has been described as a coadjutant in the treatment of hypertension. In this study, we investigated the effect of 6 weeks of swimming training on cholinergic enzyme activities (acetylcholinesterase and butyrylcholinesterase) in Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. METHODS The rats were divided into 4 groups: control (n = 10), exercise (n = 10), L-NAME (n = 10), and exercise L-NAME (n = 10). The animals were trained 5 times per week in an adapted swimming system for 60 minutes with a gradual increase of the workload up to 5% of animal's body weight. Enzyme activities were measured spectrophotometrically in lymphocytes, whole blood, and serum. RESULTS A significant rise in acetylcholinesterase activity was observed in lymphocytes and whole blood as well as in serum butyrylcholinesterase activity in the L-NAME group when compared with the other groups (P < 0.05), and the increase in cholinesterase activities was positively correlated with the rise in blood pressure (r = 0.5721, r = 0.6121, and r = 0.5811, respectively). Swimming training was efficient in preventing these alterations in the exercise L-NAME group, which displayed values similar to those of the control group. Exercise training demonstrated a significant hypotensive effect in hypertensive rats. CONCLUSIONS Exercise training was shown to prevent increased cholinesterase related to inflammatory processes in hypertensive rats, providing a new insight about protective exercise mechanisms to avoid hypertension-related inflammation.
Comparative Genomics of Four Isosphaeraceae Planctomycetes: A Common Pool of Plasmids and Glycoside Hydrolase Genes Shared by Paludisphaera borealis PX4T, Isosphaera pallida IS1BT, Singulisphaera acidiphila DSM 18658T, and Strain SH-PL62

The family Isosphaeraceae accommodates stalk-free planctomycetes with spherical cells, which can be assembled in short chains, long filaments, or aggregates. These bacteria inhabit a wide variety of terrestrial environments, among those the recently described Paludisphaera borealis PX4T that was isolated from acidic boreal wetlands. Here, we analyzed its finished genome in comparison to those of three other members of the Isosphaeraceae: Isosphaera pallida IS1BT, Singulisphaera acidiphila DSM 18658T, and the uncharacterized planctomycete strain SH-PL62. The complete genome of P. borealis PX4T consists of a 7.5 Mb chromosome and two plasmids, 112 and 43 kb in size. Annotation of the genome sequence revealed 5802 potential protein-coding genes of which 2775 could be functionally assigned. The genes encoding metabolic pathways common for chemo-organotrophic bacteria, such as glycolysis, citrate cycle, pentose-phosphate pathway, and oxidative phosphorylation were identified. Several genes involved in the synthesis of peptidoglycan as well as N-methylated ornithine lipids were present in the genome of P. borealis PX4T. A total of 26 giant genes with a size >5 kb were detected. The genome encodes a wide repertoire of carbohydrate-active enzymes (CAZymes) including 44 glycoside hydrolases (GH) and 83 glycosyltransferases (GT) affiliated with 21 and 13 CAZy families, respectively. The most-represented families are GH5, GH13, GH57, GT2, GT4, and GT83. The experimentally determined carbohydrate utilization pattern agrees well with the genome-predicted capabilities. The CAZyme repertoire in P. borealis PX4T is highly similar to that in the uncharacterized planctomycete SH-PL62 and S. acidiphila DSM 18658T, but different to that in the thermophile I. pallida IS1BT. The latter strain has a strongly reduced CAZyme content. In P. borealis PX4T, many of its CAZyme genes are organized in clusters. Contrary to most other members of the order Planctomycetales, all four analyzed Isosphaeraceae planctomycetes have plasmids in numbers varying from one to four. The plasmids from P. borealis PX4T display synteny to plasmids from other family members, providing evidence for their common evolutionary origin.
The Native Serotonin 5-HT5A Receptor: Electrophysiological Characterization in Rodent Cortex and 5-HT1A-Mediated Compensatory Plasticity in the Knock-Out Mouse

The 5-HT5A receptor is the least understood serotonin (5-HT) receptor. Here, we electrophysiologically identify and characterize a native 5-HT5A receptor current in acute ex vivo brain slices of adult rodent prefrontal cortex. In the presence of antagonists for the previously characterized 5-HT1A and 5-HT2 receptors, a proportion of layer V pyramidal neurons continue to show 5-HT-elicited outward currents in both rats and mice. These 5-HT currents are suppressed by the selective 5-HT5A antagonist, SB-699551, and are not observed in 5-HT5A receptor knock-out mice. Further characterization reveals that the 5-HT5A current is activated by submicromolar concentrations of 5-HT, is inwardly rectifying with a reversal potential near the equilibrium potential for K+ ions, and is suppressed by blockers of Kir3 channels. Finally, we observe that genetic deletion of the inhibitory 5-HT5A receptor results in an unexpected, large increase in the inhibitory 5-HT1A receptor currents. The presence of functional prefrontal 5-HT5A receptors in normal rodents along with compensatory plasticity in 5-HT5A receptor knock-out mice testifies to the significance of this receptor in the healthy prefrontal cortex.
Interactive acquisition and sharing: Understanding the dynamics of HIV/AIDS information networks

HIV/AIDS information is an important resource for people affected by the disease, particularly information that they obtain from other people. Although existing studies reveal that people with HIV/AIDS (PHAs) rely extensively on personal relationships for HIV/AIDS information, they explain little about how this happens as a social process. To investigate how PHAs and their friends/family members acquire and share network-mediated HIV/AIDS information, semistructured, in-depth interviews were conducted in three rural regions of Canada. Interviews were carried out with 114 PHAs, their friends/family members, and health care and service providers. A network solicitation and chain-referral recruitment procedure was used to delineate HIV/AIDS information networks for participants. Interview data were analyzed qualitatively and compared to Haythornthwaite’s (1996) concepts of network-mediated information processes and Talja and Hansen’s (2006) collaborative information behavior framework. Findings revealed that participants obtained HIV/AIDS information from their networks through five interactive processes: joint seeking, tag-team seeking, exposure, opportunity, and legitimation. The results of this study advance information behavior theory by pointing to the interactive character of information behavior and introducing new concepts to describe everyday life collaborative information behavior. This research also demonstrates the extensive interplay between health information exchange and the sharing of emotional support. The insights emanating from this study suggest that health information practice might benefit from a focus on program strategies such as building information network capacity, developing collaborative information retrieval systems and relationship-building, in addition to the more traditional library-related concerns of reference encounters, collections, and institutional Web sites.
Microencapsulation of Bifidobacterium animalis subsp. lactis and Lactobacillus acidophilus in cocoa butter using spray chilling technology

In the present study, the cells of Bifidobacterium animalis subsp. lactis (BI-01) and Lactobacillus acidophilus (LAC-04) were encapsulated in cocoa butter using spray-chilling technology. Survival assays were conducted to evaluate the resistance of the probiotics to the spray-chilling process, their resistance to the simulated gastric and intestinal fluids (SGF and SIF), and their stability during 90 days of storage. The viability of the cells was not affected by microencapsulation. The free and encapsulated cells of B. animalis subsp. lactis were resistant to both SGF and SIF. The micro-encapsulated cells of L. acidophilus were more resistant to SGF and SIF than the free cells; the viability of the encapsulated cells was enhanced by 67%, while the free cells reached the detection limit of the method (103 CFU/g). The encapsulated probiotics were unstable when they were stored at 20 °C. The population of encapsulated L. acidophilus decreased drastically when they were stored at 7 °C; only 20% of cells were viable after 90 days of storage. The percentage of viable cells of the encapsulated B. animalis subsp.lactis, however, was 72% after the same period of storage. Promising results were obtained when the microparticles were stored at −18 °C; the freeze granted 90 days of shelf life to the encapsulated cells. These results suggest that the spray-chilling process using cocoa butter as carrier protects L. acidophilus from gastrointestinal fluids. However, the viability of the cells during storage must be improved.
Design of norm-optimal iterative learning controllers: The effect of an iteration-domain Kalman filter for disturbance estimation

Iterative learning control (ILC) has proven to be an effective method for improving the performance of repetitive control tasks. This paper revisits two optimization-based ILC algorithms: (i) the widely used quadratic-criterion ILC law (QILC) and (ii) an estimation-based ILC law using an iteration-domain Kalman filter (K-ILC). The goal of this paper is to analytically compare both algorithms and to highlight the advantages of the Kalman-filter-enhanced algorithm. We first show that for an iteration-constant estimation gain and an appropriate choice of learning parameters both algorithms are identical. We then show that the estimation-enhanced algorithm with its iteration-varying optimal Kalman gains can achieve both fast initial convergence and good noise rejection by (optimally) adapting the learning update rule over the course of an experiment. We conclude that the clear separation of disturbance estimation and input update of the K-ILC algorithm provides an intuitive architecture to design learning schemes that achieve both low noise sensitivity and fast convergence. To benchmark the algorithms we use a simulation of a single-input, single-output mass-spring-damper system.
Automatic Detection of Machine Translated Text and Translation Quality Estimation

We show that it is possible to automatically detect machine translated text at sentence level from monolingual corpora, using text classification methods. We show further that the accuracy with which a learned classifier can detect text as machine translated is strongly correlated with the translation quality of the machine translation system that generated it. Finally, we offer a generic machine translation quality estimation technique based on this approach, which does not require reference sentences.