Miracle-dz/UniFAR-FTUs huggingface dataset:
Steganography using Cryptography and Pseudo Random Numbers

When it comes to information hiding it is always a question whether to use Steganography or cryptography. Cryptography scrambles the message so that is it unrecognizable and without proper key the Encrypted message is useless. With the help of steganography messages can be passed over the network discreetly as it provides secure data hiding. It is very challenging and emerging field of research. Steganography can be simple as LSB technique or can be complicated as transform domain techniques, each technique have their own advantage. Both of these techniques are often confused with each other because in a way both are used to hide data. This paper discusses the important aspects of Steganography and Cryptography. How a simple LSB steganography technique in images can be complicated further using combination of Cryptography and Pseudo-random number generator.
Graph Subsumption in Abstract State Space Exploration

In this paper we present the extension of an existing method for abstract graph-based state space exploration, called neighbourhood abstraction, with a reduction technique based on subsumption. Basically, one abstract state subsumes another when it covers more concrete states; in such a case, the subsumed state need not be included in the state space, thus giving a reduction. We explain the theory and especially also report on a number of experiments, which show that subsumption indeed drastically reduces both the state space and the resources (time and memory) needed to compute it.
Age of Collagen in Intracranial Saccular Aneurysms

Background and Purpose— The chronological development and natural history of cerebral aneurysms (CAs) remain incompletely understood. We used 14C birth dating of a main constituent of CAs, that is, collagen type I, as an indicator for biosynthesis and turnover of collagen in CAs in relation to human cerebral arteries to investigate this further. Methods— Forty-six ruptured and unruptured CA samples from 43 patients and 10 cadaveric human cerebral arteries were obtained. The age of collagen, extracted and purified from excised CAs, was estimated using 14C birth dating and correlated with CA and patient characteristics, including the history of risk factors associated with atherosclerosis and potentially aneurysm growth and rupture. Results— Nearly all CA samples contained collagen type I, which was <5 years old, irrespective of patient age, aneurysm size, morphology, or rupture status. However, CAs from patients with a history of risk factors (smoking or hypertension) contained significantly younger collagen than CAs from patients with no risk factors (mean, 1.6±1.2 versus 3.9±3.3 years, respectively; P=0.012). CAs and cerebral arteries did not share a dominant structural protein, such as collagen type I, which would allow comparison of their collagen turnover. Conclusions— The abundant amount of relatively young collagen type I in CAs suggests that there is an ongoing collagen remodeling in aneurysms, which is significantly more rapid in patients with risk factors. These findings challenge the concept that CAs are present for decades and that they undergo only sporadic episodes of structural change.
The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export

For mRNA to be transported from the nucleus to the cytoplasm, it must travel from the site of transcription through the nuclear interior to the nuclear pore. Studies in Saccharomyces cerevisiae have suggested a relationship between poly(A) RNA trafficking and myosin-like protein 1 (Mlp1p), a nuclear-pore associated protein that is homologous to the mammalian Tpr (translocated promoter region) protein [Kosova, B. , Panté, N. , Rollenhagen, C. , Podtelejnikov, A. , Mann, M. , Aebi, U. , and Hurt, E. (2000) J. Biol. Chem. 275, 343–350]. We identified a yeast two-hybrid interaction between the C-terminal globular domain of Mlp1p and Nab2p, a shuttling heterogeneous nuclear ribonucleoprotein that is required for mRNA export. Coimmunoprecipitation confirms that Nab2p also interacts with full-length Mlp1p and in vitro binding experiments show that Nab2p binds directly to the C-terminal domain of Mlp1p. In addition, our experiments reveal that the C-terminal domain of Mlp1p is both necessary and sufficient to cause accumulation of poly(A) RNA and Nab2p in the nucleus. We propose a model where Mlp1p acts as a checkpoint at the nuclear pore by interacting with export-competent ribonucleoprotein complexes through its C-terminal globular domain. This study identifies Nab2p as a heterogeneous nuclear ribonucleoprotein found in complex with Mlp1p and begins to delineate the path that mRNA travels from the chromatin to the nuclear pore.
Early Childhood Predictors of Post-Kindergarten Executive Function: Behavior, Parent Report, and Psychophysiology

Research Findings: This study examined whether children's executive functions before kindergarten would predict variance in executive functions after kindergarten. We obtained behavioral (working memory task performance), parent-reported (temperament-based inhibitory control), and psychophysiological (working memory–related changes in heart rate and brain electrical activity) measures of executive functions from a group of preschool-age children. After children finished kindergarten, approximately 2 years later, parents were asked to complete an assessment of children's executive function skills. A regression analysis revealed that pre-kindergarten behavioral, parent-reported, and psychophysiological measures accounted for variance in post-kindergarten executive functions. Specifically, working memory task performance, temperament-based inhibitory control, and working memory–related changes in brain electrical activity accounted for unique variance in post-kindergarten executive functions. These data provide a unique contribution to the executive function literature: No other study has examined whether behavioral, psychophysiological, and parent-reported executive function measures can account for unique variance in future executive function. Practice or Policy: These findings are discussed in relation to children's transition to school and executive function training programs.
An Ecological Approach to Interface Design

Four approaches to interface design are considered: technology centered, user centered, control centered, and use centered (ecological). Each perspective provides unique insights into pieces of the interface design problem. However, it is argued that the ecological or use centered approach provides a more comprehensive framework within which the other three perspectives can play important supporting roles. This approach goes beyond issues of information requirements to address meaning as an emergent property of a dynamic work ecology.
Effect of Electrode Types on the Solidification Cracking Susceptibility of Austenitic Stainless Steel Weld Metal

The effect of electrode types on the solidification cracking susceptibility of austenitic stainless steel weld metal was studied. Manual metal arc welding method was used to produce the joints with the tungsten inert gas welding serving as the control. Metallographic and chemical analyses of the fusion zones of the joints were conducted. Results indicate that weldments produced from E 308-16 (rutile coated), E 308-16(lime-titania coated) electrodes, and TIG welded joints fall within the range of and solidified with a duplex mode and were found to be resistant to solidification cracking. The E 308-16 weld metal had the greatest resistance to solidification cracking. Joints produced from E 310-16 had ratio < 1.5 and solidified with austenite mode. It was found to be susceptible to solidification cracking. E 312-16 produced joints having ratio > 1.9 and solidified with ferrite mode. It had a low resistance to solidification cracking.
Optimal VM migration planning for data centers

Various network optimization and management goals in cloud data centers can be achieved by re-mapping VMs to the substrate servers. Live VM migration is used to implement such re-mapping by moving VMs from the initial servers to the target ones. For efficiency and usability considerations, these migration tasks are expected to be completed as soon as possible, which can be achieved by planning multiple VMs to be migrated simultaneously. However, the available resources of computation and bandwidth limits the number of VMs that can be migrated at the same time. Besides, the available resources change with the progress of migration process, which makes VM migration planning a challenge problem. Considering both resources constraints and the dependence between the migration plan and the total migration time, in this paper, we investigate the problem of virtual machine migration planning to minimize the total migration time. We formulate VM migration planning as an optimization problem considering both computation and bandwidth constraints. Our formulation is based on a step-by-step migration scheme, where multiple VMs can be migrated simultaneously as long as the resource constraints are satisfied. The solution of the optimization problem outputs the migration plan which achieves the minimum time to finish the migration task. Moreover, we verify the effectiveness of the optimal migration plan through extensive simulations and comparison with the best algorithm in existing works.
Digital Mapping of Soil Salinity and Crop Yield across a Coastal Agricultural Landscape Using Repeated Electromagnetic Induction (EMI) Surveys

Reliable and real-time information on soil and crop properties is important for the development of management practices in accordance with the requirements of a specific soil and crop within individual field units. This is particularly the case in salt-affected agricultural landscape where managing the spatial variability of soil salinity is essential to minimize salinization and maximize crop output. The primary objectives were to use linear mixed-effects model for soil salinity and crop yield calibration with horizontal and vertical electromagnetic induction (EMI) measurements as ancillary data, to characterize the spatial distribution of soil salinity and crop yield and to verify the accuracy of spatial estimation. Horizontal and vertical EMI (type EM38) measurements at 252 locations were made during each survey, and root zone soil samples and crop samples at 64 sampling sites were collected. This work was periodically conducted on eight dates from June 2012 to May 2013 in a coastal salt-affected mud farmland. Multiple linear regression (MLR) and restricted maximum likelihood (REML) were applied to calibrate root zone soil salinity (ECe) and crop annual output (CAO) using ancillary data, and spatial distribution of soil ECe and CAO was generated using digital soil mapping (DSM) and the precision of spatial estimation was examined using the collected meteorological and groundwater data. Results indicated that a reduced model with EMh as a predictor was satisfactory for root zone ECe calibration, whereas a full model with both EMh and EMv as predictors met the requirement of CAO calibration. The obtained distribution maps of ECe showed consistency with those of EMI measurements at the corresponding time, and the spatial distribution of CAO generated from ancillary data showed agreement with that derived from raw crop data. Statistics of jackknifing procedure confirmed that the spatial estimation of ECe and CAO exhibited reliability and high accuracy. A general increasing trend of ECe was observed and moderately saline and very saline soils were predominant during the survey period. The temporal dynamics of root zone ECe coincided with those of daily rainfall, water table and groundwater data. Long-range EMI surveys and data collection are needed to capture the spatial and temporal variability of soil and crop parameters. Such results allowed us to conclude that, cost-effective and efficient EMI surveys, as one part of multi-source data for DSM, could be successfully used to characterize the spatial variability of soil salinity, to monitor the spatial and temporal dynamics of soil salinity, and to spatially estimate potential crop yield.
Biochemical and genetical studies on ribose catabolism in Escherichia coli K12.

SUMMARY: A gene specifying ribokinase has been located on the Escherichia coli chromosome close to the reported position of an uncharacterized ribose*-negative mutation. This uncharacterized mutant has been shown to lack ribose permease and thus the genes for two enzymes of ribose catabolism are close together on the chromosome.
Development and Evaluation of an Algorithm for the Computer-Assisted Segmentation of the Human Hypothalamus on 7-Tesla Magnetic Resonance Images

Post mortem studies have shown volume changes of the hypothalamus in psychiatric patients. With 7T magnetic resonance imaging this effect can now be investigated in vivo in detail. To benefit from the sub-millimeter resolution requires an improved segmentation procedure. The traditional anatomical landmarks of the hypothalamus were refined using 7T T1-weighted magnetic resonance images. A detailed segmentation algorithm (unilateral hypothalamus) was developed for colour-coded, histogram-matched images, and evaluated in a sample of 10 subjects. Test-retest and inter-rater reliabilities were estimated in terms of intraclass-correlation coefficients (ICC) and Dice's coefficient (DC). The computer-assisted segmentation algorithm ensured test-retest reliabilities of ICC≥. 97 (DC≥96.8) and inter-rater reliabilities of ICC≥. 94 (DC = 95.2). There were no significant volume differences between the segmentation runs, raters, and hemispheres. The estimated volumes of the hypothalamus lie within the range of previous histological and neuroimaging results. We present a computer-assisted algorithm for the manual segmentation of the human hypothalamus using T1-weighted 7T magnetic resonance imaging. Providing very high test-retest and inter-rater reliabilities, it outperforms former procedures established at 1.5T and 3T magnetic resonance images and thus can serve as a gold standard for future automated procedures.
An open-label, three-arm pilot study of the safety and efficacy of topical Microcyn Rx wound care versus oral levofloxacin versus combined therapy for mild diabetic foot infections.

BACKGROUND This randomized, prospective, multicenter, open-label study was designed to test whether a topical, electrolyzed, superoxidized solution (Microcyn Rx) is a safe and effective treatment for mildly infected diabetic foot ulcers. METHODS Sixty-seven patients with ulcers were randomized into three groups. Patients with wounds irrigated with Microcyn Rx alone were compared with patients treated with oral levofloxacin plus normal saline wound irrigation and with patients treated with oral levofloxacin plus Microcyn Rx wound irrigation. Patients were evaluated on day 3, at the end of treatment on day 10 (visit 3), and 14 days after completion of therapy for test of cure (visit 4). RESULTS In the intention-to-treat sample at visit 3, the clinical success rate was higher in the Microcyn Rx alone group (75.0%) than in the saline plus levofloxacin group (57.1%) or in the Microcyn Rx plus levofloxacin group (64.0%). Results at visit 4 were similar. In the clinically evaluable population, the clinical success rate at visit 3 (end of treatment) for patients treated with Microcyn Rx alone was 77.8% versus 61.1% for the levofloxacin group. The clinical success rate at visit 4 (test of cure) for patients treated with Microcyn Rx alone was 93.3% versus 56.3% for levofloxacin plus saline-treated patients. This study was not statistically powered, but the high clinical success rate (93.3%) and the P value (P = .033) suggest that the difference is meaningfully positive for Microcyn Rx-treated patients. CONCLUSIONS Microcyn Rx is safe and at least as effective as oral levofloxacin for mild diabetic foot infections.
Genetic relatedness of noroviruses identified in sporadic gastroenteritis in children and gastroenteritis outbreaks in Northern Alberta

We compared the proportion and genotype distribution of norovirus (NoV) identified in sporadic acute gastroenteritis in children younger than 7 years old with the NoV strains found in outbreaks from January 2003 through April 2004 in northern Alberta, Canada. Eight genogroup I (GI) and 133 GII NoV cases were detected in 1,166 cases of acute sporadic childhood gastroenteritis with a monthly detection rates varying from 6.0% to 20.4% and no sporadic gastroenteritis case in October 2003. Seventy‐eight outbreaks (65%) tested positive for NoV during the study period with an obvious winter predominance and no NoV outbreaks in August, September, and October 2003. Three GI and 51 GII strains from the sporadic childhood gastroenteritis cases and seven GI and 37 GII strains from gastroenteritis outbreaks were sequenced and analyzed. Strains belonging to the GII.4 cluster predominated in outbreaks (68%) while the strains in sporadic childhood gastroenteritis demonstrated significant heterogeneity with the majority belonging to the GII.3 cluster (36%). Further analysis of NoV strains from 34 sporadic childhood gastroenteritis cases and 38 gastroenteritis outbreaks in chronologically and geographically related groups failed to demonstrate clear link between strains circulating in the setting of sporadic childhood gastroenteritis and those found in outbreaks. J. Med. Virol. 80:330–337, 2008. © 2007 Wiley‐Liss, Inc.
Effects of Mountains and Ice Sheets on Global Ocean Circulation

AbstractThe impact of mountains and ice sheets on the large-scale circulation of the world’s oceans is investigated in a series of simulations with a new coupled ocean–atmosphere model [Oregon State University–University of Victoria model (OSUVic)], in which the height of orography is scaled from 1.5 times the actual height (at T42 resolution) to 0 (no mountains). The results suggest that the effects of mountains and ice sheets on the buoyancy and momentum transfer from the atmosphere to the surface ocean determine the present pattern of deep ocean circulation. Higher mountains reduce water vapor transport from the Pacific and Indian Oceans into the Atlantic Ocean and contribute to increased (decreased) salinities and enhanced (reduced) deep-water formation and meridional overturning circulation in the Atlantic (Pacific). Orographic effects also lead to the observed interhemispheric asymmetry of midlatitude zonal wind stress. The presence of the Antarctic ice sheet cools winter air temperatures by more th.
Convex Analysis of Spectrally Defined Matrix Functions

The purpose of this work is to carry out a systematic study of a special class of convex functions defined over the space $S_n$ of symmetric matrices of order $n\ti n$. The functions under consideration $(\Phi: S_n \ra R\cup \{+\infty\})$ are spectrally defined in the sense that the value $\Phi(A)$ depends only on the spectrum $\{\lam_1(A), \ldots, \lam_n(A)\}$ of the matrix $A\in S_n$. Fenchel--Legendre conjugation, first- and second-order subdifferentiability, asymptotic behavior, and other concepts of convex analysis are the main ingredients of our exposition.
Peptide Microarray-Based Identification of Mycobacterium tuberculosis Epitope Binding to HLA-DRB1*0101, DRB1*1501, and DRB1*0401

ABSTRACT A more effective vaccine against Mycobacterium tuberculosis is needed, and a number of M. tuberculosis vaccine candidates are currently in preclinical or clinical phase I and II studies. One of the strategies to select M. tuberculosis (protein) targets to elicit a CD8+ or CD4+ T-cell response is to gauge the binding of candidate peptides to major histocompatibility complex (MHC) class I or class II molecules, a prerequisite for successful peptide presentation and to expand antigen-specific T cells. We scanned 61 proteins from the M. tuberculosis proteome for potential MHC class II-presented epitopes that could serve as targets for CD4+ T-cell responses. We constructed a peptide microarray consisting of 7,466 unique peptides derived from 61 M. tuberculosis proteins. The peptides were 15-mers overlapping by 12 amino acids. Soluble recombinant DRB1*0101 (DR1), DRB1*1501 (DR2), and DRB1*0401 (DR4) monomers were used to gauge binding to individual peptide species. Out of 7,466 peptides, 1,282, 674, and 1,854 peptides formed stable complexes with HLA-DR1, -DR2, and -DR4, respectively. Five hundred forty-four peptides bound to all three MHC class II molecules, 609 bound to only two, and 756 bound to only a single MHC class II molecule. This allowed us to rank M. tuberculosis proteins by epitope density. M. tuberculosis proteins contained “hot spots,” i.e., regions with enriched MHC class II binding epitopes. Two hundred twenty-two peptides that formed MHC class II-peptide complexes had previously been described as exclusively recognized by IgG in sera from patients with active pulmonary tuberculosis, but not in sera from healthy individuals, suggesting that these peptides serve as B-cell and CD4+ T-cell epitopes. This work helps to identify not only M. tuberculosis peptides with immunogenic potential, but also the most immunogenic proteins. This information is useful for vaccine design and the development of future tools to explore immune responses to M. tuberculosis.
Patient noncompliance with self‐administered chemotherapy

The contribution of patient factors to nonadherence with self‐administered cancer chemotherapy along with its prevalence was studied. Fifty‐one patients with breast cancer enrolled in protocols that included the orally administered medications Cytoxan (cyclophosphamide) and/or prednisone were interviewed and assessed at five points in time over a 6‐month period. Two summary measures of patient nonadherence derived by self‐report were developed: (1) dosage, the overall percentage of drug missed during 26 weeks of treatment; and (2) behavioral, the percentage of behavioral events or prescribing occasions on which a criterion level of drug was missed. Twenty‐two patients (43%) met criteria for noncompliance according to both behavioral and dosage definitions. Univariate analyses showed more nonadherence in the clinic and private community settings than in the academic setting. Stepwise multiple logistic regression analyses assessed the contribution of patient demographic, psychologic, and physical symptom factors on patient noncompliance. In the regression analyses patient noncompliance was associated with (1) treatment location, more nonadherence in the private community‐based treatment sector than in the academic setting; and (2) income, more nonadherence among those having lower incomes. In assessing total dose requirements in clinical research trials, rates of patient nonadherence need to be considered, and treatment location controlled.