Miracle-dz/UniFAR-FTUs huggingface dataset:
Future Expectations as a Source of Resilience among Young People Leaving Care

Young adults who leave care enter a crucial period in their lives in which they have to plan their future and make significant decisions regarding many aspects of their adult life (Arnett, 2000). During emerging adulthood, their expectations for the future are especially important and could influence their goal setting and motivation to accomplish those goals. However, little attention has been paid to the importance of future expectations of care leavers as a source of resilience. This paper aims to address the role of future expectations among young people leaving care in the context of resilience theory and emerging adulthood theory. It describes the challenges these youth face in transition to adulthood and the role that future expectations play during this period. Further, it reviews studies that examine the correlations between future expectations, resilience and outcomes, and focuses on two possible personal and environmental resources that can contribute to care leavers’ positive future expectations: optimism and social support. In addition, it articulates the possible links connecting future expectations with resilience. Finally, it suggests a unified approach that integrates both environmental and personal components for increasing future expectations and concludes with implications for practice and directions for future
Parallel Cone Bipolar Pathways to a Ganglion Cell Use Different Rates and Amplitudes of Quantal Excitation

The cone signal reaches the cat's On-β (X) ganglion cell via several parallel circuits (bipolar cell types b1, b2, and b3). These circuits might convey different regions of the cone's temporal bandwidth. To test this, I presented a step of light that elicited a transient depolarization followed by a sustained depolarization. The contribution of bipolar cells to these response components was isolated by blocking action potentials with tetrodotoxin and by blocking inhibitory synaptic potentials with bicuculline and strychnine. Stationary fluctuation analysis of the sustained depolarization gave the rate of quantal bombardment: ∼5100 quanta sec−1 for small central cells and ∼45,000 quanta sec−1 for large peripheral cells. Normalizing these rates for the vastly different numbers of bipolar synapses (150–370 per small cell vs 2000 per large cell), quantal rate was constant across the retina, ∼22 quanta synapse−1 sec−1. Nonstationary fluctuation analysis gave the mean quantal EPSP amplitude: ∼240 μV for the transient depolarization and 30 μV for the sustained depolarization. The b1 bipolar cell is known from noise analysis of the On-α ganglion cell to have a near-maximal sustained release of only approximately two quanta synapse−1 sec−1. This implies that the other bipolar types (b2 and b3) contribute many more quanta to the sustained depolarization (≥46 synapse−1 sec−1). Type b1 probably contributes large quanta to the transient depolarization. Thus, bipolar cell types b1 and b2/b3 apparently constitute parallel circuits that convey, respectively, high and low frequencies.
Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype.

OBJECTIVE A functional polymorphism has been described in the promoter region of the gene (SLC6A4) coding for the serotonin transporter protein (SERT). This polymorphism has two common alleles, designated as long and short. Each allele has been linked with a number of human clinical phenotypes, including neuropsychiatric diseases associated with dysregulation of serotonin transmission. In vitro studies of nonneural cells have suggested that the long allele may have higher transcriptional activity than the short allele. However, the relevance of these findings for SERT levels in the brain remains unclear. METHOD The authors assessed genotypes at the SLC6A4 promoter polymorphism in 96 healthy European American subjects who underwent single photon emission computed tomography scanning with [123I]2beta-carbomethoxy-3beta-(4-iodophenyl) tropane ([123I]beta-CIT) for measurement of central SERT availability. A ratio of specific to nondisplaceable brain uptake (i.e., V3"=[brainstem-diencephalon-occipital]/occipital), a measure proportional to the binding potential (Bmax/KD), was derived. RESULTS The results showed that the main effect of genotype was significant. Post hoc Tukey pairwise comparisons revealed that the short-short homozygotes had significantly greater SERT availability than the long-short heterozygotes. There was a nonsignificant tendency for the long-long homozygotes to have greater SERT availability than the heterozygotes, but no difference was observed between the long-long homozygotes and the short-short homozygotes. The effect of age was significant in the analysis of covariance model. CONCLUSIONS These results do not suggest higher central SERT levels in association with the long allele in European American subjects but point to a more complex relationship between SLC6A4 genotype and protein availability.
Antibodies against Tumor Cell Glycolipids and Proteins, but Not Mucins, Mediate Complement-Dependent Cytotoxicity1

One of several effector mechanisms thought to contribute to Ab efficacy against cancer is complement-dependent cytotoxicity (CDC). Serological analysis of a series of clinical trials conducted over a 10-year period suggested that six vaccines containing different glycolipids induced Abs mediating CDC whereas four vaccines containing carbohydrate or peptide epitopes carried almost exclusively by mucin molecules induced Abs that did not mediate CDC. To explore this further, we have now compared cell surface reactivity using flow cytometry assays (FACS), complement-fixing ability, and CDC activity of a panel of mAbs and immune sera from these trials on the same two tumor cell lines. Abs against glycolipids GM2, globo H and Lewis Y, protein KSA (epithelial cell adhesion molecule, also known as EpCAM) and mucin Ags Tn, sialylated Tn, Thomsen Friedenreich (TF), and MUC1 all reacted comparably by FACS with tumor cells expressing these Ags. Compared with the strong complement binding and CDC with Abs against glycolipids and KSA, complement binding was diminished with Abs against mucin Ags and no CDC was detected. A major difference between these two groups of Ags is proximity to the cell membrane. Glycolipids and globular glycoproteins extend less than 100 Å from the cell membrane while mucins extend up to 5000 Å. Although complement activation at sites remote from the cell membrane has long been known as a mechanism for resistance from complement lysis in bacteria, it is identified here for the first time as a factor which may contribute to resistance from CDC against cancer cells.
Lead-me interface for a pulling sensation from hand-held devices

When a small mass in a hand-held device oscillates along a single axis with asymmetric acceleration (strongly peaked in one direction and diffuse in the other), the holder typically experiences a kinesthetic illusion characterized by the sensation of being continuously pushed or pulled by the device. This effect was investigated because of its potential application to a hand-held, nongrounded, haptic device that can convey a sense of a continuous translational force in one direction, which is a key missing piece in haptic research. A 1 degree-of-freedom (DOF) haptic device based on a crank-slider mechanism was constructed. The device converts the constant rotation of an electric motor into the constrained movement of a small mass with asymmetric acceleration. The frequency that maximizes the perceived movement offered by the haptic device was investigated. Tests using three subjects showed that for the prototype, the best frequencies were 5 and 10 cycles per second.
Architecting in the Automotive Domain: Descriptive vs Prescriptive Architecture

To investigate the new requirements and challenges of architecting often safety critical software in the automotive domain, we have performed two case studies on Volvo Car Group and Volvo Group Truck Technology. Our findings suggest that automotive software architects produce two different architectures (or views) of the same system. The first one is a high-level descriptive architecture, mainly documenting system design decisions and describing principles and guidelines that should govern the overall system. The second architecture is the working architecture, defining the actual blueprint for the implementation teams and being used in their daily work. The working architecture is characterized by high complexity and considerably lower readability than the high-level architecture. Unfortunately, the team responsible for the high-level architecture tends to get isolated from the rest of the development organization, with few communications except regarding the working architecture. This creates tensions within the organizations, sub-optimal design of the communication matrix and limited usage of the high-level architecture in the development teams. To adapt to the current pace of software development and rapidly growing software systems new ways of working are required, both on technical and on an organizational level.
Decreasing False Positive Detection of Haar-Like Based Face Detection using Skin Color Filtering for Crowded Face Images

This paper presents an improvement of Haar-Like features based face detection which main aim to decrease the false positive detection using skin color filtering approach. The face detection algorithm starts from lighting normalization, face region detection, and face verification. The skin color filtering approach is used to verify whether the detected face region contains much skin color and has the appropriate face size for the images having crowded faces. The proposed method is better compared to the recent method which is shown by much higher accuracy and much less false rejection rate.
Acute Corrosive Injuries of the Stomach: A Single Unit Experience of Thirty Years

Introduction. The spectrum of gastric injury due to corrosives can vary. This paper presents a single center experience of over 30 years of corrosive gastric injuries of 39 patients with acute gastric injuries from 1977 till 2006. Patients and Methods. Two thirds of the patients in the acute injury group had a concomitant esophageal injury. The age of the patients ranged from 4 years to 65 years with a slight preponderance of males. (M : F ratio 22 : 17). Results. 36 out of 39 acute gastric injuries were due to ingestion of acids. Three patients had history of caustic soda ingestion. Oral hyperemia or ulcers of varying extent were seen in all patients. The stomach showed hyperemia in 10, extensive ulcers in 13, and mucosal necrosis in 10 patients. Fifteen patients (15/39, 38.5%) were managed conservatively. Twenty four patients (24/39, 61.5%) underwent laparotomy: one for frank peritonitis, 10 for gastric mucosal necrosis, and 13 others for extensive gastric ulcerations. Overall the mortality rate was 29.6 %. Conclusion. Although the mortality and morbidity of acute corrosive gastric injuries is high, the key to improve the survival is early identification of perforation, maintenance of nutrition and control of sepsis.
The Effect of Science Journal Writing on the Science-Related Affective Domain of Scientifically Gifted Students at Middle School Level

The purpose of this study was to investigate the effect of science journal writing on science-related affects of scientifically gifted students at middle school level. Twenty one gifted students attending a university science gifted program wrote science journals for two months in a web-supported environment. The data sources include student journals, questionnaire and exit interviews. The results indicate that science journal writing has influenced the students positively in the affective domain, and in particular, cognitions of science, interests in science and scientific attitudes.
Consciousness and cognitive control

The implementation or change of information processing routines, known as cognitive control, is traditionally believed to be closely linked to consciousness. It seems that we exert control over our behavior if we know the reasons for, and consequences of, doing so. Recent research suggests, however, that several behavioral phenomena that have been construed as instances of cognitive control can be prompted by events of which actors are not aware. Here we give a brief review of this research, discuss possible reasons for inconsistencies in the empirical evidence, and suggest some lines of future research. Specifically, we suggest to differentiate cognitive control evoked either because of explicit or because of implicit control cues. While the former type of control seems to work outside of awareness, the latter type of control seems to be restricted to consciously registered events that call for control.
Development of an ultrasensitive immunoassay for human glandular kallikrein with no cross-reactivity from prostate-specific antigen.

BACKGROUND Studies demonstrating that human glandular kallikrein (hK2) is increased in prostate cancer patients have prompted speculation that this marker may of use in addition to prostate-specific antigen (PSA). METHODS An ultrasensitive hK2 sandwich immunoassay was developed, and its detection limit, cross-reactivity, analytical recovery, precision, and linearity of dilution were evaluated. hK2 was measured in seminal plasma and sera from healthy males, females, and prostatectomized patients. RESULTS Our assay has an excellent detection limit (6 ng/L) and precision (>90%). Recovery studies indicated that hK2 binds to serum protease inhibitors. All sera from healthy males had measurable hK2 concentrations (median, 402 ng/L). Almost all female sera had undetectable hK2. Serum hK2 and PSA in males correlated positively (r = 0.44), but hK2 was present at concentrations approximately 2. 5-fold lower than PSA. The PSA/hK2 ratio in male sera was 0.1-34, with a median of 2.6. In seminal plasma, this ratio was 100-500. More than 94% of immunoreactive hK2 in serum was in the free form ( approximately 30 kDa); traces of hK2 complexed to alpha1-antichymotrypsin were present. CONCLUSIONS The limit of detection of the method for hK2 measurement described here ( approximately 20-fold lower than any other reported assay for hK2) allows the generation of new clinical information. When combined with a previously described method for PSA measurement that has no cross-reactivity from hK2, this methods allows the relative proportions of hK2 and PSA in biological fluids to be measured.
A Framework of Multi-Authority Attribute-Based Encryption with Outsourcing and Revocation

Attribute-based encryption (ABE) is a cryptographic tool for fine-grained data access control. For practical needs, an ABE scheme should support multiple authority and revocation. Furthermore, decryption should also be outsourced for higher efficiency. Researchers have been extending existing ABE schemes for these goals. Yet, the rationales are often hidden behind tailor-made number-theoretic constructions. This paper proposes a framework for constructing multi-authority ABE schemes with attribute revocation and outsourced decryption, from any pairing-based single-authority ABE scheme which satisfies a set of properties we identified.
Whole-genome sequencing of an advanced case of small-cell gallbladder neuroendocrine carcinoma

The majority of gallbladder cancer cases are discovered at later stages, which frequently leads to poor prognoses. Small-cell gallbladder neuroendocrine carcinoma (GB-SCNEC) is a relatively rare histological type of gallbladder cancer, and its survival rate is exceptionally low because of its greater malignant potential. In addition, the genomic landscape of GB-SCNEC is rarely considered in treatment decisions. We performed whole-genome sequencing on an advanced case of GB-SCNEC. By analyzing the whole-genome sequencing data of the primary cancer tissue (76.29X coverage), lymphatic metastatic cancer tissue (73.92X coverage) and matched non-cancerous tissue (35.73X coverage), we identified approximately 900 high-quality somatic single nucleotide variants (SNVs), 109 of which were shared by both the primary and metastatic tumor tissues. Somatic non-synonymous coding variations with damaging impact in HMCN1 and CDH10 were observed in both the primary and metastatic tissue specimens. A pathway analysis of the genes mapped to the SNVs revealed gene enrichment associated with axon guidance, ERBB signaling, sulfur metabolism and calcium signaling. Furthermore, we identified 20 chromosomal rearrangements that included 11 deletions, 4 tandem duplications and 5 inversions that mapped to known genes. Two gene fusions, NCAM2-SGCZ and BTG3-CCDC40 were also discovered and validated by Sanger sequencing. Additionally, we identified genome-wide copy number variations and microsatellite instability. In this study, we identified novel biological markers of GB-SCNEC that may serve as valuable prognostic factors or indicators of treatment response in patients with GB-SCNEC with lymphatic metastasis.
Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome

Anatomical analyses of occipital and temporal cortex of patients with fragile X mental retardation syndrome (FXS) and in a mouse model of the syndrome (FraX mice) compared to controls have suggested that the fragile X mental retardation protein (FMRP) is important for normal spine structural maturation and pruning. However, a recent analysis of spine properties in somatosensory cortex of young FraX mice has suggested that this region may not exhibit spine abnormalities. While spine abnormalities were present 1 week after birth in somatosensory cortex, by 4 weeks almost all spine abnormalities had disappeared, suggesting that adult spine abnormalities observed in other cortical regions may not persist post‐developmentally in somatosensory cortex. To resolve this discrepancy we examined spine properties in somatosensory cortex of young (day 25) and adult (day 73–76) FraX compared to wild‐type (WT) mice. Spine properties in young FraX and WT mice did not consistently differ from each other, consistent with the recent analysis of developing somatosensory cortex. However, adult FraX mice exhibited increased spine density, longer spines, more spines with an immature‐appearing structure, fewer shorter spines, and fewer spines with a mature structure, a pattern consistent with prior analyses from other adult cortical brain regions in humans and mice. These findings (1) support the previous report of the absence of major spine abnormalities in the fourth postnatal week, (2) demonstrate normal spine development in WT mice, (3) demonstrate abnormal spine development after the fourth postnatal week in FraX mice, and (4) demonstrate spine abnormalities in somatosensory cortex of adult FraX compared to adult WT mice. In doing so, these findings resolve a potential conflict in the literature and more thoroughly describe the role of FMRP in spine development. © 2005 Wiley‐Liss, Inc.
CSI_GED: An efficient approach for graph edit similarity computation

Graph similarity is a basic and essential operation in many applications. In this paper, we are interested in computing graph similarity based on edit distance. Existing graph edit distance computation methods adopt the best first search paradigm A*. These methods are time and space bound. In practice, they can compute the edit distance of graphs containing 12 vertices at most. To enable graph edit similarity computation on larger and distant graphs, we present CSI_GED, a novel edge-based mapping method for computing graph edit distance through common sub-structure isomorphisms enumeration. CSI_GED utilizes backtracking search combined with a number of heuristics to reduce memory requirements and quickly prune away a large portion of the mapping search space. Experiments show that CSI_GED is highly efficient for computing the edit distance on small as well as large and distant graphs. Furthermore, we evaluated CSI_GED as a stand-alone graph edit similarity search query method. The experiments show that CSI_GED is effective and scalable, and outperforms the state-of-the-art indexing-based methods by over two orders of magnitude.
MOCASSIN: a fully three-dimensional Monte Carlo photoionization code

The study of photoionized environments is fundamental to many astrophysical problems. Up to the present most photoionization codes have numerically solved the equations of radiative transfer by making the extreme simplifying assumption of spherical symmetry. Unfortunately very few real astronomical nebulae satisfy this requirement. To remedy these shortcomings, a self-consistent, three-dimensional radiative transfer code has been developed using Monte Carlo techniques. The code, MOCASSIN, is designed to build realistic models of photoionized nebulae having arbitrary geometry and density distributions, with both the stellar and diffuse radiation fields treated self-consistently. In addition, the code is capable of treating one or more exciting stars located at non-central locations. The gaseous region is approximated by a cuboidal Cartesian grid composed of numerous cells. The physical conditions within each grid cell are determined by solving the thermal equilibrium and ionization balance equations. This requires a knowledge of the local primary and secondary radiation fields, which are calculated self-consistently by locally simulating the individual processes of ionization and recombination. The structure and the computational methods used in the MOCASSIN code are described in this paper. MOCASSIN has been benchmarked against established one-dimensional spherically symmetric codes for a number of standard cases, as defined by the Lexington/Meudon photoionization workshops: at Meudon in 1985 and at Lexington in 1995 and 2000. The results obtained for the benchmark cases are satisfactory and are presented in this paper. A performance analysis has also been carried out and is discussed here.
Nonbinary Hybrid LDPC Codes

In this paper, a new class of low-density parity-check (LDPC) codes, named hybrid LDPC codes, is introduced. Hybrid LDPC codes are characterized by an irregular connectivity profile and heterogeneous orders of the symbols in the codeword. It is shown in particular that the class of hybrid LDPC codes can be asymptotically characterized and optimized using density evolution (DE) framework, and a technique to maximize the minimum distance of the code is presented. Numerical assessment of hybrid LDPC code performances is provided, by comparing them to protograph-based and multiedge-type (MET) LDPC codes. Hybrid LDPC codes are shown to allow to achieve an interesting tradeoff between good error-floor performance and good waterfall region with nonbinary coding techniques.
Singularities of solutions to the Schrödinger equation on scattering manifold

In this paper we study microlocal singularities of solutions to Schr\"odinger equations on scattering manifolds, i.e., noncompact Riemannian manifolds with asymptotically conic ends. We characterize the wave front set of the solutions in terms of the initial condition and the classical scattering maps under the nontrapping condition. Our result is closely related to a recent work by Hassell and Wunsch, though our model is more general and the method, which relies heavily on scattering theoretical ideas, is simple and quite different. In particular, we use an Egorov-type argument in the standard pseudodifferential symbol classes, and avoid using Legendre distributions. In the proof, we employ a microlocal smoothing property in terms of the {\it radially homogenous wave front set}, which is more precise than the preceding results.