Miracle-dz/UniFAR-FTUs huggingface dataset:
A First Study on a Fuzzy Rule-Based Multiclassification System Framework Combining FURIA with Bagging and Feature Selection

In this work, we conduct a preliminary study considering a fuzzy rule-based multiclassification system design framework based on Fuzzy Unordered Rule Induction Algorithm (FURIA). This advanced method serves as the fuzzy classification rule learning algorithm to derive the component classifiers considering bagging combined with feature selection. We develop a study on the use of both bagging and feature selection to design a final FURIA-based fuzzy multiclassifier applied to ten popular UCI datasets. The results obtained show that this approach provides promising results.
Adolescents' Perceptions of the Seriousness of Sexual Aggression: Influence of Gender, Traditional Attitudes, and Self-Reported Experience

Little is known about adolescents' perceptions of interpersonal aggression and the role of traditional social attitudes in these perceptions. Sixteen-year-old students (N = 212) of both sexes rated the seriousness of 9 aurally presented scenarios depicting either sexual or nonsexual, physical aggression. Sex of perpetrator and sex of victim were manipulated partly factorially. Students also reported on their own experiences (as perpetrators and victims) of the aggression portrayed, and completed a measure of traditional sex role ideology. Sexual aggression was rated as more serious than nonsexual physical aggression, especially when involving physical force. Girls gave higher seriousness ratings than did boys. Male-to-female aggression was rated as most serious, and male-to-male aggression, least serious. Self-reported perpetrators tended to give lower ratings of seriousness than did victims. Traditional sex-role attitudes were associated with lower rated seriousness but not with reported perpetration or victimization. Multivariate analyses suggested that the effects of traditional sex-role attitudes could largely be subsumed by the effects of other study variables, especially participant sex. The role of attitudes as a direct cause of interpersonal aggression is discussed along with implications for intervention.
Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus

With age, there is a progressive loss of body balance function. Yet, the potential influence of osteoporosis on body balance is largely unknown. Dentin matrix protein 1 (DMP1) is highly expressed in bone and required for phosphate homeostasis and mineralization. Dmp1 null mice display striking defects in bone structure. In this study we reported circling behavior and hyper reaction to touching in Dmp1 null mice. Our histology, tartrate resistant acid phosphatase (TRAP) staining and µCT data showed dramatic changes, such as an expansion of poorly mineralized matrices, in the Dmp1 null porous bony structure in the vestibular apparatus. The targeted re-expression of DMP1 in the Dmp1 null bone fully rescued not only the bone phenotype, but also circling behavior and hyper reaction. Furthermore, X-gal stain and DMP1 immunohistochemistry assay showed that DMP1 was not expressed in neuron cells or balance related cells in the inner ear, suggesting that a defect in the bony labyrinth of the internal ear is indirectly responsible for the circling behavior and/or hyper reaction to touching. Finally, discovery of DMP1 lacZ signal in pericyte-like cells may suggest a new function of DMP1 in angiogenesis.
Exploiting Dynamical Complexity in a Physical Tensegrity Robot to Achieve Locomotion

The emerging field of morphological computation seeks to understand how mechanical complexity in living systems can be advantageous, for instance by reducing the cost of control. In this paper we explore the phenomenon of morphological computation in tensegrities – unique structures with a high strength to weight ratio, resilience, and an ability to change shape. These features have great value as a robotics platform, but also make tensegrities difficult to control via conventional techniques. We describe a novel approach to the control of tensegrity robots which, rather than suppressing complex dynamics, exploits them in order to achieve locomotion. Our robots are physically embodied (rather than simulated), evolvable, and locomote at higher speeds (relative to body size) and with fewer actuators than those controlled by more conventional approaches.
Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins.

AIM There is a substantial difference between Asians and Caucasians in their reaction to platinum drugs. To determine whether population-related genomics contribute to differences in patient outcomes, pharmacogenomic relevance of polymorphisms in some genes, the protein activities of which may affect aspects of cisplatin metabolism, were evaluated. PATIENTS & METHODS Nineteen polymorphisms in ten genes were tested for correlations with the efficacy and toxicity of a cisplatin-cyclophosphamide regimen in Yakut and Russian patients with ovarian cancer. RESULTS The CYP2E1 7632T>A polymorphism was associated with progression-free survival (p = 0.015) in Yakuts. In Russians, progression-free survival was correlated with the GSTP1 Ile105Val polymorphism (p = 0.004). Yakut patients with the GSTT1-null genotype had a higher risk for nephrotoxicity. By contrast, in the Russian group, nephrotoxicity was more frequent among patients with heterozygous ERCC1 genotypes. Severe emesis in Yakuts was independently associated with two polymorphisms in the CYP2E1 gene but in Russians, it was more common in patients with the GSTT1-null genotype. Differences in genotypic correlations with anemia were also observed. CONCLUSION Significant differences in genotype distribution between Russian and Yakut women were observed for ten of the 19 polymorphisms, but none of them seemed to be a clear casual candidate and further studies involving more markers are required.
Timing of magnetite formation in basaltic glass: Insights from synthetic analogs and relevance for geomagnetic paleointensity analyses

Absolute paleointensity estimates from submarine basaltic glass (SBG) typically are of high technical quality and accurately reflect the ambient field when known. SBG contains fine‐grained, low‐Ti magnetite, in contrast to the high‐Ti magnetite in crystalline basalt, which has lead to uncertainty over the origin of the magnetite and its remanence in SBG. Because a thermal remanence is required for accurate paleointensity estimates, the timing and temperature of magnetite formation is crucial. To assess these factors, we generated a suite of synthetic glasses with variable oxygen fugacity, cooling rate, and FeO* content. Magnetic properties varied most strongly with crystallinity; less crystalline specimens are similar to natural SBG and have weaker magnetization, a greater superparamagnetic contribution, and higher unblocking temperatures than more crystalline specimens. Thellier‐type paleointensity results recovered the correct field within 1σ error with 2 (out of 10) exceptions that likely result from an undetected change in the laboratory field. Unblocking and ordering temperature data demonstrate that low‐Ti magnetite is a primary phase, formed when the glass initially quenched. Although prolonged heating at high temperatures (during paleointensity experiments) may result in minor alteration at temperatures < 580°C, this does not appear to impact the accuracy of the paleointensity estimate. Young SBG is therefore a suitable material for paleointensity studies.
Induction of IL‐33 expression and activity in central nervous system glia

IL‐33 is a novel member of the IL‐1 cytokine family and a potent inducer of type 2 immunity, as mast cells and Th2 CD4+ T cells respond to IL‐33 with the induction of type 2 cytokines such as IL‐13. IL‐33 mRNA levels are extremely high in the CNS, and CNS glia possess both subunits of the IL‐33R, yet whether IL‐33 is produced by and affects CNS glia has not been studied. Here, we demonstrate that pathogen‐associated molecular patterns (PAMPs) significantly increase IL‐33 mRNA and protein expression in CNS glia. Interestingly, IL‐33 was localized to the nucleus of astrocytes. Further, CNS glial and astrocyte‐enriched cultures treated with a PAMP followed by an ATP pulse had significantly higher levels of supernatant IL‐1β and IL‐33 than cultures receiving any single treatment (PAMP or ATP). Supernatants from PAMP + ATP‐treated glia induced the secretion of IL‐6, IL‐13, and MCP‐1 from the MC/9 mast cell line in a manner similar to exogenous recombinant IL‐33. Further, IL‐33 levels and activity were increased in the brains of mice infected with the neurotropic virus Theiler's murine encephalomyelitis virus. IL‐33 also had direct effects on CNS glia, as IL‐33 induced various innate immune effectors in CNS glia, and this induction was greatly amplified by IL‐33‐stimulated mast cells. In conclusion, these results implicate IL‐33‐producing astrocytes as a potentially critical regulator of innate immune responses in the CNS.
Modern concepts in computer-assisted craniomaxillofacial reconstruction

Purpose of reviewTo review the past year's literature regarding current computer-assisted reconstruction techniques and their outcomes. Recent findingsCurrent computer-assisted craniofacial reconstruction research is focused on data acquisition, planning, surgical and assessment phases. The major areas of interest among researchers include cosmetic surgery; cleft and craniofacial surgery; traumatic reconstruction, head and neck tumor reconstruction; and orthognathic surgery and distraction osteogenesis. Recent advances in the fields include facial analysis and planning in rhinoplasty, facial surface and bone graft volume analysis in cleft surgery, computer-guided tumor ablation and osteocutaneous reconstruction in tumor surgery, and preoperative planning and surgical assistance in orthognathic and distraction osteogenesis surgery. SummaryResearch in computer-aided craniofacial surgery is progressing at a rapid rate. Rather than just the latest innovation, sound research studies are proving computer assistance to be invaluable in producing superior outcomes, especially in the fields of head and neck surgery, orthognathic surgery, and craniomaxillofacial trauma surgery. Further outcome studies and cost-benefit analyses are still needed to show the superiority of these methods to contemporary techniques.
Activation of Rac, Cdc42 and other downstream signalling molecules by Bartonella bacilliformis during entry into human endothelial cells

Bartonella bacilliformis is an intracellular bacterial pathogen of human endothelial cells. In vitro incubation of B. bacilliformis with human endothelial cells leads to the formation of filamentous actin extensions (filopodia) within 30 min, followed by formation of membrane rufflings or lamellipodia within 1 h of incubation. By immunofluorescence, F‐actin phalloidin staining and anti‐Rac antibodies were shown to co‐localize in the membrane rufflings, indicating the recruitment of activated Rac at lamellipodia. Preincubation of endothelial cells with the Clostridial toxin, TcdB‐10463, which inactivates the Rho‐family GTPases, Rho, Rac and Cdc42, inhibited the entry of B. bacilliformis by 50–90%. Preincubation of endothelial cells with the Clostridial toxin, TcsL‐1522, which specifically inactivates Rac and, to a lesser extent, Cdc42, but not Rho, inhibited entry by 30–40%. A 3.4–5.0‐fold increase in activated (GTP‐bound) intracellular Rac and Cdc42 was observed in affinity precipitation assays. Increased kinase activity of p21‐activated kinase (PAK), a specific downstream effector of activated Rac/Cdc42 was also observed during the time course of infection. Activation of SAPK/JNK‐1 and 2, and p38 MAPKs in signalling pathways, was also detected during infection with Bartonella, as was increased binding activity of AP‐1 transcription factor.
Usefulness of anti-PF4/heparin antibody test for intensive care unit patients with thrombocytopenia

Background It is critical to differentiate heparin-induced thrombocytopenia (HIT) from disseminated intravascular coagulation (DIC) in heparinized intensive care unit (ICU) patients with thrombocytopenia because the therapeutic approach differs based on the cause. We investigated the usefulness of PF4/heparin antibody tests in these patients. Methods A total of 127 heparinized ICU patients whose platelet counts were <150×109/L or reduced by >50% after 5-10 days of heparin therapy were enrolled. PF4/heparin antibodies were measured using 2 immunoassays. We assessed the probability of HIT by using Warkentin's 4T's scoring system for antibody positive patients and compared routinely performed coagulation test results between patients with and without antibodies to evaluate the ability of these tests to discriminate between HIT and DIC. Results Positive results were obtained for 14 (11.0%) and 11 (8.7%) patients in the 2 assays. The analysis performed using the 4T's scoring system revealed that 11 of 20 (15.7%) patients with antibodies in at least 1 assay had intermediate or greater probability of HIT. Patients without antibodies had significantly higher levels of D-dimer than those with antibodies. However, there were no intergroup differences in platelet counts, PT, aPTT, fibrinogen, DIC score, and rate of overt DIC. Conclusion Seropositivity for PF4/heparin antibody was 8.7-11.0% in the patients with thrombocytopenia, and more than a half of them had an increased probability of HIT. Among the routine coagulation tests, only D-dimer was informative for differentiating HIT from DIC. PF4/heparin antibody test is useful to ensure appropriate treatment for thrombocytopenic heparinized ICU patients.
Gröbner Basis Based Cryptanalysis of SHA-1

Recently, Wang proposed a new method to cryptanalyze SHA-1 and found collisions of 58-round SHA-1. However many details of Wang’s attack are still unpublished, especially, 1) How to find differential paths? 2) How to modify messages properly? For the first issue, some results have already been reported. In our article, we clarify the second issue and give a sophisticated method based on Gröbner basis techniques. We propose two algorithm based on the basic and an improved message modification techniques re­ spectively. The complexity of our algorithm to find a collision for 58-round SHA-1 based on the basic message modification is 2 message modifications and its implementation is equivalent to 2 SHA-1 computation experimentally, whereas Wang’s method needs 2 SHA-1 computation. The proposed improved message modification is applied to construct a more sophisticated algorithm to find a collision. The complexity to find a collision for 58-round SHA-1 based on this improved message modification technique is 2 message modifications, but our latest implementation is very slow, equivalent to 2 SHA-1 com­ putation experimentally. However we conjecture that our algorithm can be improved by techniques of error correcting code and Gröbner basis. By using our methods, we have found many collisions for 58-round SHA-1.
On Type Ia Supernovae From The Collisions of Two White Dwarfs

ABSTRACT We explore collisions between two white dwarfs as a pathway for making Type IaSupernovae (SNIa). White dwarf number densities in globular clusters allow 10 100redshift . 1 collisions per year, and observations by (Chomiuk et al.2008) of globularclusters in the nearby S0 galaxy NGC 7457 have detected what is likely to be a SNIaremnant. We carry out simulations of the collision between two 0.6M white dwarfsat various impact parameters and mass resolutions. For impact parameters less thanhalf the radius of the white dwarf, we nd such collisions produce ˇ 0.4 M of 56 Ni,making such events potential candidates for underluminous SNIa or a new class oftransients between Novae and SNIa.Key words: hydrodynamics { nuclear reactions, nucleosynthesis, abundances {(stars:) white dwarfs { (stars:) supernovae: general. 1 INTRODUCTIONType Ia supernovae (henceforth SNIa) play a key role inastrophysics as premier distance indicators for cosmology(Phillips 1993; Riess et al.1998; Perlmutter et al.1999), asdirect probes of low-mass star formation rates at cosmologi-cal distances (Scannapieco et al.2005; Mannucci et al.2006;Maoz 2008) and as signi cant contributors to iron-groupelements in the cosmos (Wheeler et al.1989; Timmes etal.1995; Feltzing et al.2001; Strigari 2006). Our current un-derstanding is that there are two major progenitor systemsfor these events. The rst possibility, the single-degeneratescenario, consists of a carbon-oxygen white dwarf in a bi-nary system evolving to the stage of central ignition by massoverow from a low-mass stellar companion (Whelan & Iben1973; Nomoto 1982; Hillebrandt & Niemeyer 2000). The sec-ond possibility, the double-degenerate scenario, consists ofthe merger of two white dwarfs in a binary system (Iben& Tutukov 1984; Webbink 1984; Yoon et al.2007). It is un-known at what relative frequency both of these channelsoperate (Livio 2000; Maoz 2008). Collisions between two white dwarfs, are likely to hap-pen less frequently than binary mergers. However, as dis-cussed in Timmes (2009) and Rosswog et al.(2009), theywill occur in globular clusters where the stellar densities areextremely high. For a typical globular cluster velocity dis-persion of ˇ5-10 km s
Flexural properties of steel fiber types and reinforcement ratio for high-strength recycled concrete beams

This article took fly ash and silica fume as cementing materials to replace part of cement and took recycled coarse aggregate to replace part of gravel to mix plain concrete and studied the flexural properties of the beams with high-strength steel fiber–recycled concrete by changing the types of steel fiber and reinforcement ratio. The results showed that fly ash and silica fume could improve strength and flexural capacity of the recycled concrete beam by filling micro-cracks of recycled coarse aggregate and reduce the development speed of deflection and crack width of the test beam. Steel fibers could significantly slow the development of deflection and crack width of the beams with high-strength recycled concrete, and the difference in end-structure could increase the flexural capacity of the beams in varying degrees. The article put forward theory of improving the bearing capacity of the beam with three kinds of steel fibers by introducing the influence factor of steel fiber end-structure.
[Family environment and attention-deficit hyperactivity disorder].

OBJECTIVE To analyze factors associated with attention-deficit and hyperactivity disorder in children. METHODS This is a longitudinal study about behavior problems in schoolchildren that was carried out in the city of São Gonçalo (Southeastern Brazil) in 2005. A total of 479 students from public schools was analyzed, selected through three-stage cluster sampling. The Child Behavior Checklist was used to measure the outcome. A questionnaire was administered to parents/guardians concerning the exposure factors, which were: child's and family's profile, family relationship variables, physical and psychological violence. The log-binomial regression model with a hierarchical approach was employed in the analysis. RESULTS Higher intelligence quotient was inversely associated with the frequency of the disorder (PR=0.980 [95%CI 0.963;0.998]). The prevalence of the disorder in the children was higher when there was family dysfunction than among families with a better way of relating (PR=2.538 [95%CI 1.572; 4.099]). Children who suffered verbal abuse from the mother had a prevalence 3.7 times higher than the ones not exposed to this situation in the last year (PR=4.7 [95%CI 1.254;17.636]). CONCLUSIONS Negative family relationships are associated with symptoms of Attention-Deficit and Hyperactivity Disorder. Its association with the intelligence quotient reiterates the importance of the genetic and environmental basis at the origin of the disorder.
Management of placenta accreta

Cesarean hysterectomy is considered the reference standard treatment for placenta accreta. In young women who want the option of future pregnancy and agree to close follow‐up monitoring, conservative treatment is a valid option. Several key points of both cesarean hysterectomy and conservative treatment remain debatable, such as timing of delivery, attempted removal of the placenta, use of temporal internal iliac occlusion balloon catheters, ureteral stents, prophylactic embolization, and methotrexate. In cases of placenta percreta with bladder involvement, conservative treatment may be the optimal management. Regardless of the chosen option, the woman and her partner should be warned of the high risk of maternal complications related to an abnormally invasive placenta.
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions

The normal intestinal microbiota inhabits the colon mucus without triggering an inflammatory response. The reason for this and how the intestinal mucus of the colon is organized have begun to be unraveled. The mucus is organized in two layers: an inner, stratified mucus layer that is firmly adherent to the epithelial cells and approximately 50 μm thick; and an outer, nonattached layer that is usually approximately 100 μm thick as measured in mouse. These mucus layers are organized around the highly glycosylated MUC2 mucin, forming a large, net-like polymer that is secreted by the goblet cells. The inner mucus layer is dense and does not allow bacteria to penetrate, thus keeping the epithelial cell surface free from bacteria. The inner mucus layer is converted into the outer layer, which is the habitat of the commensal flora. The outer mucus layer has an expanded volume due to proteolytic activities provided by the host but probably also caused by commensal bacterial proteases and glycosidases. The numerous O-glycans on the MUC2 mucin not only serve as nutrients for the bacteria but also as attachment sites and, as such, probably contribute to the selection of the species-specific colon flora. This observation that normal human individuals carry a uniform MUC2 mucin glycan array in colon may indicate such a specific selection.
Canonical Wnt signaling is required for the maintenance of dorsal retinal identity

Accurate retinotectal axon pathfinding depends upon the correct establishment of dorsal-ventral retinal polarity. We show that dorsal retinal gene expression is regulated by Wnt signaling in the dorsal retinal pigment epithelium (RPE). We find that a Wnt reporter transgene and Wnt pathway components are expressed in the dorsal RPE beginning at 14-16 hours post-fertilization. In the absence of Wnt signaling, tbx5 and Bmp genes initiate normal dorsal retinal expression but are not maintained. The expression of these genes is rescued by the downstream activation of Wnt signaling, and tbx5 is rescued by Bmp signaling. Furthermore, activation of Wnt signaling cannot rescue tbx5 in the absence of Bmp signaling, suggesting that Wnt signaling maintains dorsal retinal gene expression by regulating Bmp signaling. We present a model in which dorsal RPE-derived Wnt activity maintains the expression of Bmp ligands in the dorsal retina, thus coordinating the patterning of these two ocular tissues.