Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship of Proinsulin and Insulin to Cardiovascular Risk Factors in Nondiabetic Subjects

Recent data suggest that proinsulin is strongly associated with cardiovascular risk factors in diabetic subjects. However, this relationship has not been examined in nondiabetic subjects. Therefore, we examined the relation of proinsulin to lipids, obesity (body mass index), and waist-to-hip ratio in 260 nondiabetic individuals from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Proinsulin was measured by radioimmunoassay, and insulin was measured by a Linco radioimmunoassay that does not cross-react with proinsulin. Fasting insulin was significantly associated with body mass index (0.42), waist-to-hip ratio (r = 0.30), triglyceride (r = 0.29), high-density lipoprotein cholesterol (r = −0.20), and systolic blood pressure (r = 0.16) but not significantly related to diastolic blood pressure (r = 0.11). Fasting proinsulin was significantly associated with body mass index (r = 0.19), waist-to-hip ratio (r = 0.25), triglyceride (r = 0.41), systolic blood pressure (r = 0.19), and diastolic blood pressure (r = 0.15). Proinsulin was more strongly related to increased triglyceride than insulin despite its weaker relationship to obesity. In multivariate analyses, proinsulin continued to be significantly related to triglyceride concentrations (explaining 23.1% of the variance) and to systolic blood pressure (explaining 4.0% of the variance), even after adjusting for insulin. These observations suggest that proinsulin should be measured in addition to insulin in epidemiological studies. Proinsulin may be a marker for metabolic decompensation in prediabetic subjects.
Robust frailty modelling using non-proportional hazards models

Correlated survival times can be modelled by introducing a random effect, or frailty component, into the hazard function. For multivariate survival data, we extend a non-proportional hazards (PH) model, the generalized time-dependent logistic survival model, to include random effects. The hierarchical likelihood procedure, which obviates the need for marginalization over the random effect distribution, is derived for this extended model and its properties are discussed. The extended model leads to a robust estimation result for the regression parameters against the misspecification of the form of the basic hazard function or frailty distribution compared to PH-based alternatives. The proposed method is illustrated by two practical examples and a simulation study which demonstrate the advantages of the new model.
Language and understanding of cardiopulmonary resuscitation amongst an aged inpatient population

Abstract Greater patient involvement in health decision-making requires exchange of information between the patient and the healthcare professionals. Decisions regarding healthcare at the end of life include consideration of cardiopulmonary resuscitation (CPR). The stated objectives of this study were to determine how often language around concepts of resuscitation is used in the community by examination of the English language corpora (ELC); to explore the understanding of the same language by a group of older hospital patients; and to determine the patients’ knowledge of the process and success of CPR, as well as the sources of their information. Medical inpatients aged 75 years and older were surveyed to this end in the setting of a tertiary university teaching hospital. Interrogation of the Australian, British and American English Corpora was accomplished by a linguist, and a questionnaire and semi-structured interview were administered to ascertain patient knowledge. We demonstrated that although medical inpatients have some familiarity with terms relating to resuscitation, there is a lack of understanding of the context, process and outcomes of CPR. The predominant sources of information were television and print media. Examination of the ELC revealed a paucity of the use of terms related to resuscitation. This finding indicates that physicians have a duty of care to determine patients’ understanding around resuscitation language, and terms used, in discussions of their preferences before assuming their engagement in shared decision-making. More open public discussion around death and resuscitation would increase the general knowledge of the population and would provide a better foundation for the discussions in times of need.
Static and Fatigue Behavior Investigation of Artificial Notched Steel Reinforcement

Pitting corrosion is one of the most common forms of localized corrosion. Corrosion pit results in a stress concentration and fatigue cracks usually initiate and propagate from these corrosion pits. Aging structures may fracture when the fatigue crack reaches a critical size. This paper experimentally simulates the effects of pitting morphologies on the static and fatigue behavior of steel bars. Four artificial notch shapes are considered: radial ellipse, axial ellipse, triangle and length-variable triangle. Each shape notch includes six sizes to simulate a variety of pitting corrosion morphologies. The stress-strain curves of steel bars with different notch shape and depth are obtained based on static tensile testing, and the stress concentration coefficients for various conditions are determined. It was determined that the triangular notch has the highest stress concentration coefficient, followed by length-variable triangle, radial ellipse and axial ellipse shaped notches. Subsequently, the effects of notch depth and notch aspect ratios on the fatigue life under three stress levels are investigated by fatigue testing, and the equations for stress range-fatigue life-notch depth are obtained. Several conclusions are drawn based on the proposed study. The established relationships provide an experimental reference for evaluating the fatigue life of concrete bridges.
Clinical, functional and radiographic consequences of achieving stable low disease activity and remission with adalimumab plus methotrexate or methotrexate alone in early rheumatoid arthritis: 26-week results from the randomised, controlled OPTIMA study

Objective To assess the efficacy and safety of adalimumab plus methotrexate (ADA+MTX) compared with methotrexate monotherapy in achieving stable low disease activity (LDA; disease activity score (DAS28(CRP)) <3.2 at weeks 22 and 26) and clinical, radiographic and functional outcomes in methotrexate-naive patients with early rheumatoid arthritis (RA). Methods 1032 patients with active RA were randomly assigned 1:1 to ADA+MTX or placebo plus methotrexate (PBO+MTX) for 26 weeks. Treatment modifications were to be made in a subsequent study period based on the achievement of DAS28(CRP) <3.2 at weeks 22 and 26. Post-hoc analyses compared patients achieving stable remission using DAS28 and 2010 ACR/EULAR criteria with those achieving LDA but not remission. Results Among patients completing 6 months, 44% (207/466) ADA+MTX versus 24% (112/460) PBO+MTX patients achieved stable LDA at weeks 22 and 26 (p<0.001). Combination therapy was statistically superior to methotrexate in obtaining higher ACR20/50/70 responses, more clinical remissions, greater mean reductions in DAS28(CRP), no radiographic progression, and normal functional status at week 26 (p<0.001 for all). The only factor predicting stable LDA was disease activity at week 12. Patients achieving ACR/EULAR remission, particularly in the PBO+MTX group, had some advantage in radiographic outcomes compared with patients who only achieved LDA (but not remission). The overall frequency of adverse events was comparable between groups. There were more serious infections and deaths in the ADA+MTX group, with a possible age effect. Conclusions Treatment with ADA+MTX was significantly superior to methotrexate alone with respect to clinical, radiographic and functional outcomes in patients with early active RA. Before initiating treatment with adalimumab, individual patient evaluation of the benefit/risk ratio should be carefully considered.
Induction of Carbon Starvation-Induced Proteins in Vibrio vulnificus

By using two-dimensional polyacrylamide gel electrophoresis of pulse-labelled proteins, carbon starvation-induced (Sti) proteins produced by Vibrio vulnificus were identified. At least 34 proteins were induced over a 26-h period of carbon starvation. Although the total rate of protein synthesis over the 26-h starvation period suggests that there is a dramatic decrease in total protein synthesis within the first hour of starvation, at least 23 of the Sti proteins were induced within the first 20 min of carbon depletion. Six temporal classes of proteins could be identified, with class A(ii) encompassing the largest (21 proteins) group. All of the proteins in this group could be characterized by one of two patterns of protein synthesis. The addition of chloramphenicol at sequential times throughout starvation revealed that proteins required for starvation survival are made within the first 4 h of starvation.
Dis/counting of women : a critical feminist analysis of two secondary social studies textbooks

Two secondary social studies textbooks, Canada: A Nation Unfolding, and Canada Today were analyzed with regard to the inclusion of the lives, experiences, perspectives and contributions of females throughout history and today. Drawing on the existing literature,-a framework of analysis was created comprised of four categories: 1) language; 2) visual representation; 3) positioning and; 4) critical analysis of content. Each of these categories was further broken into a series of related subcategories in order to examine in depth and detail, the portrayal of women in these two textbooks. Each book was carefully read and then analyzed for instances of gender bias as informed by the analytical framework. Neither of the books was. free from gender bias. Although the authors of the textbooks are careful to employ gender inclusive language, language used to describe women's lives, experiences and contributions is problematic. It often denies them agency and categorizes them as members of nameless, faceless collectives. Visually, women in these two textbooks are under represented, and the manner of the representation is problematic, particularly when attention is given to traditional and non-traditional roles (for both men and women). Frequently, information about women is included outside of the main text, reinforcing their historical marginalization. Finally, the textbooks were found to be neither fair or equitable with regard to women's historical contributions.
Structure Tensor Total Variation

We introduce a novel generic energy functional that we employ to solve inverse imaging problems within a variational framework. The proposed regularization family, termed as structure tensor total variation (STV), penalizes the eigenvalues of the structure tensor and is suitable for both grayscale and vector-valued images. It generalizes several existing variational penalties, including the total variation seminorm and vectorial extensions of it. Meanwhile, thanks to the structure tensor's ability to capture first-order information around a local neighborhood, the STV functionals can provide more robust measures of image variation. Further, we prove that the STV regularizers are convex while they also satisfy several invariance properties w.r. t. image transformations. These properties qualify them as ideal candidates for imaging applications. In addition, for the discrete version of the STV functionals we derive an equivalent definition that is based on the patch-based Jacobian operator, a novel linear operator which extends the Jacobian matrix. This alternative definition allow us to derive a dual problem formulation. The duality of the problem paves the way for employing robust tools from convex optimization and enables us to design an efficient and parallelizable optimization algorithm. Finally, we present extensive experiments on various inverse imaging problems, where we compare our regularizers with other competing regularization approaches. Our results are shown to be systematically superior, both quantitatively and visually.
Transfer and transitioning: Students' experiences in a secondary school in Trinidad and Tobago

In Trinidad and Tobago, parents, teachers, and students use several factors in choosing a secondary school of their choice. However, not all students are given their first choice of school. In an attempt to ensure the best educational experience available, some parents use the route of requesting, from the Ministry of Education, a transfer out of the school to which the student was first admitted into another they perceive as better. This makes those students "second-transfer" students, as they have already experienced the transfer process from a primary school into a secondary school. Using a phenomenological methodology, this study explored the experiences of the transitioning process of students who transferred from one secondary school to another, as they appeared to have difficulties adjusting to a new school environment. Two male and three female students from Forms 2 to 4, at different stages of transitioning, and three of their teachers were purposely selected to participate in the study. Data collected through interviews were analysed using the Constant Comparative Method (Glaser & Strauss, 1967). Findings indicated that transitioning positively affected them as they experienced a stable environment in their new school, and negatively affected them academically, with males faring worse than females. Their negative experiences diminshed over time as they adjusted and found their niche in the new school environment. The insights gained from the study can be useful to the school administration and the education system in understanding the transitioning process.
An Analysis of Structural Features, Contents, and Cognitive Levels of Questions of Korea and Secondary Textbooks in the Evolution Unit

The purpose of this study was to seek strengths and weaknesses from analyzing Korea and U.S. science textbooks in terms of general structural features, contents, cognitive levels of questions and the purpose of questions used in science textbooks. This provided insight into improvement of textbooks that can effectively assist teaching and learning. To investigate organization of unit in textbooks in-depth, the evolution unit was selected and scrutinized as one example. The results showed that the number of pages, activities, vocabulary words, and vocabulary lists are considerably different between Korean and the U.S. Commonly, U.S. textbooks were more laden with information and lacking in coherence than those of the Korean textbooks. The findings on the cognitive levels of questions showed that the majority of questions in both nations are concerned with knowledge. However, the difference between the two nations is great in the ratios of analysis, synthesis, and evaluation questions. Questions are concentrated in review section (45% of Korean and 60.6% of U.S.) in textbooks. It suggested that well-planned questions in a review section can provide the basic guidance for strength in a science classroom.
Phenotypic and genetic characterization of rhizobia isolated from Hedysarum flexuosum in Northwest region of Morocco

Seventy bacterial strains were isolated from root nodules of the legume Hedysarum flexuosum grown wild in soils from Northwest Morocco. Repetitive extragenic palindromic (REP)‐polymerase chain reaction (PCR) clustered the strains into 30 REP‐PCR groups. The nearly complete sequence of the 16S rRNA gene from a representative strain of each REP‐PCR pattern showed that 17 strains were closely related to members of the genus Rhizobium of the family Rhizobiaceae of the Alphaproteobacteria. Pairwise alignments between globally aligned sequences of the 16S rRNA gene indicated that the strains from H. flexuosum had 99.75–100% identity with Rhizobium sullae type strain IS123T. The phenotypic characteristics analyzed allowed description of a wide physiological diversity among the isolates, where the carbohydrate assimilation test was the most discriminating. Analysis of the 16S rRNA gene of a representative strains from the remaining 13 REP‐PCR groups showed they belong to a wide variety of phylogenetic groups being closely related to species of genera Stenotrophomonas, Serratia, Massilia, Acinetobacter, Achromobacter, and Pseudomonas from the Beta‐ and Gammaproteobacteria. The R. sullae strains identified in this study produced effective symbiosis with their original host plant. None of the other bacterial strains could form nodules on H. flexuosum.
Comparison of Fat Necrosis Between Zone II and Zone III in Pedicled Transverse Rectus Abdominis Musculocutaneous Flaps: A Prospective Study of 400 Consecutive Cases

Fat necrosis in transverse rectus abdominis musculocutaneous (TRAM) flap is considered to be mainly affected by blood supply. This prospective study compares the incidence of fat necrosis between zones II and III in 400 consecutive patients who had undergone unipedicled TRAM flap breast reconstruction. Fifty-eight patients (14.5%) suffered from fat necrosis, and 7 had 2 separate nodules. Fifty-four occurred in zone II, 10 in zone III, and 1 in zone I. The incidence of fat necrosis in zone II was significantly higher than in zone III (P < 0.001). The weight of the mastectomy specimen and the relative amount of zone II tissue included in the flap had positive correlation with the incidence of fat necrosis. This result implies relatively poor perfusion of zone II compared with zone III.
Stability of Facial Affective Expressions in Schizophrenia

Thirty-two videorecorded interviews were conducted by two interviewers with eight patients diagnosed with schizophrenia. Each patient was interviewed four times: three weekly interviews by the first interviewer and one additional interview by the second interviewer. 64 selected sequences where the patients were speaking about psychotic experiences were scored for facial affective behaviour with Emotion Facial Action Coding System (EMFACS). In accordance with previous research, the results show that patients diagnosed with schizophrenia express negative facial affectivity. Facial affective behaviour seems not to be dependent on temporality, since within-subjects ANOVA revealed no substantial changes in the amount of affects displayed across the weekly interview occasions. Whereas previous findings found contempt to be the most frequent affect in patients, in the present material disgust was as common, but depended on the interviewer. The results suggest that facial affectivity in these patients is primarily dominated by the negative emotions of disgust and, to a lesser extent, contempt and implies that this seems to be a fairly stable feature.
Preferred basis in a measurement process.

The effect of decoherence is analysed for a free particle, interacting with an environment via a dissipative coupling. The interaction between the particle and the environment occurs by a coupling of the position operator of the particle with the environmental degrees of freedom. By examining the exact solution of the density matrix equation one finds that the density matrix becomes completely diagonal in momentum with time while the position space density matrix remains nonlocal. This establishes the momentum basis as the emergent 'preferred basis' selected by the environment which is contrary to the general expectation that position should emerge as the preferred basis since the coupling with the environment is via the position coordinate.
Genetic analysis of tomato golden mosaic virus: the coat protein is not required for systemic spread or symptom development

The geminiviruses are a unique group of higher plant viruses that are composed of twin isometric particles which contain circular, single‐stranded DNA. Tomato golden mosaic virus (TGMV), a whitefly‐transmitted agent, belongs to the subgroup of geminiviruses whose members possess a bipartite genome. The TGMV A genome component has the capacity to encode at least four proteins. One of these is the viral coat protein, as inferred by homology with coat‐protein, genes of other geminiviruses and by the observation of typical geminate particles in transgenic plants that contain inserts of TGMV A DNA. We have investigated the role of the coat protein in TGMV replication and report here that its coding sequence may be interrupted or substantially deleted without loss of infectivity. However, certain coat‐protein mutants showed reproducible delays in time of symptom appearance as well as reduced symptom development, when inoculated onto transgenic Nicotiana benthamiana plants containing the TGMV B component. The most attenuated symptoms were seen with a mutant in which the coat‐protein coding sequence was almost entirely deleted. The significance of these findings for the development of plant vectors from TGMV DNA is discussed.
Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine

Chemotherapy is a major treatment modality for individuals affected by cancer. Currently, a number of genome‐based technologies are being adopted to identify genes associated with drug response; however, large‐scale genetic association applications are still limited. Here we describe a novel strategy based on the genetic and drug response data of the NCI60 cell lines to discover potential candidate genetic variants associated with variable response to chemotherapy. As an example we have applied this strategy to discover single genetic markers and haplotypes from candidate genes previously implicated in the pharmacobiology of gemcitabine. Single‐marker association analyses have implicated the association of four SNPs within the gene loci of CDC5L, EPC2, POLS, and PARP1. We have also investigated the combined effect of SNPs using haplotype‐based analysis. Accordingly, we have shown modest association of haplotypes in six genes, whereas the most significant associations included a haplotype of the POLS gene. The hypothesis‐generating tool presented in this study can be applied to drugs profiled in the NCI60 cell line screen and provides an effective means for the identification of genes associated with drug response. The results obtained using this novel methodology can be used to better design the clinical trials for effective study of the chemotherapeutic agents and thus provide a basis for individualized chemotherapy. Hum Mutat 29(4), 461–467, 2008. © 2008 Wiley‐Liss, Inc.
John Peel's Home Truths

Although widely regarded as the most influential British radio DJ of the last century, John Peel was also a presenter of speech radio. This article examines his career presenting two BBC Radio 4 speech programmes; ‘Offspring’ and ‘Home Truths’. Research carried out included interviews with radio producers, close listening to selected programmes presented by Peel as well as reviewing the literature on radio presentation and broadcast talk. The evidence shows that Peel's success owed a lot to his ability to create a distinct radio persona, one which inspired a unique listening community. Themes of eccentricity, English nationalism, parenting and ageing were central to ‘Home Truths’ as were nostalgic references to the past. The article begins with a consideration of some of the relevant literature on radio presentation and DJs followed by an account of Peel's early career. His experience writing for ‘Radio Times’ is described and the influence this had on his selection to present on Radio 4. There are detailed accounts of the genesis of both ‘Offspring’ and its successor, ‘Home Truths’ which explain the roles of women producers in their creation. Peel's persona is discussed with reference to concepts of broadcast talk, discursive space and co-presence.