Miracle-dz/UniFAR-FTUs huggingface dataset:
Intraoperative Defibrillation Testing of Subcutaneous Implantable Cardioverter‐Defibrillator Systems—A Simple Issue?

Background The results of the recently published randomized SIMPLE trial question the role of routine intraoperative defibrillation testing. However, testing is still recommended during implantation of the entirely subcutaneous implantable cardioverter‐defibrillator (S‐ICD) system. To address the question of whether defibrillation testing in S‐ICD systems is still necessary, we analyzed the data of a large, standard‐of‐care prospective single‐center S‐ICD registry. Methods and Results In the present study, 102 consecutive patients received an S‐ICD for primary (n=50) or secondary prevention (n=52). Defibrillation testing was performed in all except 4 patients. In 74 (75%; 95% CI 0.66–0.83) of 98 patients, ventricular fibrillation was effectively terminated by the first programmed internal shock. In 24 (25%; 95% CI 0.22–0.44) of 98 patients, the first internal shock was ineffective and further internal or external shock deliveries were required. In these patients, programming to reversed shock polarity (n=14) or repositioning of the sensing lead (n=1) or the pulse generator (n=5) led to successful defibrillation. In 4 patients, a safety margin of <10 J was not attained. Nevertheless, in these 4 patients, ventricular arrhythmias were effectively terminated with an internal 80‐J shock. Conclusions Although it has been shown that defibrillation testing is not necessary in transvenous ICD systems, it seems particular important for S‐ICD systems, because in nearly 25% of the cases the primary intraoperative test was not successful. In most cases, a successful defibrillation could be achieved by changing shock polarity or by optimizing the shock vector caused by the pulse generator or lead repositioning.
Reconceptualizing the chlamydial inclusion as a pathogen-specified parasitic organelle: an expanded role for Inc proteins

Chlamydia is an obligate intracellular pathogen that develops in the host cell in a vacuole termed the chlamydial inclusion. The prevailing concept of the chlamydial inclusion is of a parasitophorous vacuole. Here, the inclusion is the recipient of one-way host-pathogen interactions thus draining nutrients from the cell and negatively impacting it. While Chlamydia orchestrates some aspects of cell function, recent data indicate host cells remain healthy up until, and even after, chlamydial egress. Thus, while Chlamydia relies on the host cell for necessary metabolites, the overall function of the host cell, during chlamydial growth and development, is not grossly disturbed. This is consistent with the obligate intracellular organism's interest to maintain viability of its host. To this end, Chlamydia expresses inclusion membrane proteins, Incs, which serve as molecular markers for the inclusion membrane. Incs also contribute to the physical structure of the inclusion membrane and facilitate host-pathogen interactions across it. Given the function of Incs and the dynamic interactions that occur at the inclusion membrane, we propose that the inclusion behaves similarly to an organelle-albeit one that benefits the pathogen. We present the hypothesis that the chlamydial inclusion acts as a pathogen-specified parasitic organelle. This representation integrates the inclusion within existing subcellular trafficking pathways to divert a subset of host-derived metabolites thus maintaining host cell homeostasis. We review the known interactions of the chlamydial inclusion with the host cell and discuss the role of Inc proteins in the context of this model and how this perspective can impact the study of these proteins. Lessons learnt from the chlamydial pathogen-specified parasitic organelle can be applied to other intracellular pathogens. This will increase our understanding of how intracellular pathogens engage the host cell to establish their unique developmental niches.
An RFID tag system-on-chip with wireless ECG monitoring for intelligent healthcare systems

This paper presents a low-power wireless ECG acquisition system-on-chip (SoC), including an RF front-end circuit, a power unit, an analog front-end circuit, and a digital circuitry. The proposed RF front-end circuit can provide the amplitude shift keying demodulation and distance to digital conversion to accurately receive the data from the reader. The received data will wake up the power unit to provide the required supply voltages of analog front-end (AFE) and digital circuitry. The AFE, including a pre-amplifier, an analog filter, a post-amplifier, and an analog-to-digital converter, is used for the ECG acquisition. Moreover, the EPC Class I Gen 2 UHF standard is employed in the digital circuitry for the handshaking of communication and the control of the system. The proposed SoC has been implemented in 0.18-μm standard CMOS process and the measured results reveal the communication is compatible to the RFID protocol. The average power consumption for the operating chip is 12 μW. Using a Sony PR44 battery to the supply power (605mAh@1.4V), the RFID tag SoC operates continuously for about 50,000 hours (>5 years), which is appropriate for wireless wearable ECG monitoring systems.
An Iterative Algorithm to Determine the Dynamic User Equilibrium in a Traffic Simulation Model

An iterative algorithm to determine the dynamic user equilibrium with respect to link costs defined by a traffic simulation model is presented. Each driver's route choice is modeled by a discrete probability distribution which is used to select a route in the simulation. After each simulation run, the probability distribution is adapted to minimize the travel costs. Although the algorithm does not depend on the simulation model, a queuing model is used for performance reasons. The stability of the algorithm is analyzed for a simple example network. As an application example, a dynamic version of Braess's paradox is studied.
Distribution of glutamic acid decarboxylase immunoreactivity within the brain of oval squid Sepioteuthis lessoniana

Coleoid cephalopods (squid, cuttlefish, and octopus) have the largest and most complex brains of all invertebrates and show behavioral abilities similar to those of vertebrates. Among the coleoids, the oval squid Sepioteuthis lessoniana forms well-structured schools that are indicative of sociality. These behaviors are re flected in aspects of the well-developed brain. In this study, we focused on the role of the cephalopod brain in complex behavior. In order to reveal the network of γ-aminobutyric acid (GABA) in coleoids, we examined the immunohistochemical localization of glutamic acid decarboxylase (GAD), which is the synthetic enzyme of GABA, in the brain of young S. lessoniana. We found that GABAergic neurons and their axons were distributed throughout the brain. GABA neurons were abundantly localized in the inferior frontal lobe, which is involved in controlling arm motions, and in the subesophageal masses, which are lower and intermediate centers of action. GABAergic fibers were abundantly localized in the tract that runs from the superior frontal lobe to the vertical lobe. These results sug- gested the involvement of GABA in both cognitive behaviors (such as learning and memory) and in movement.
HIT-CIR: An Unsupervised WSD System Based on Domain Most Frequent Sense Estimation

This paper presents an unsupervised system for all-word domain specific word sense disambiguation task. This system tags target word with the most frequent sense which is estimated using a thesaurus and the word distribution information in the domain. The thesaurus is automatically constructed from bilingual parallel corpus using paraphrase technique. The recall of this system is 43.5% on SemEval-2 task 17 English data set.
The Relative Importance of the Sedge Island Marine Conservation Zone for Adult Blue Crabs in Barnegat Bay, New Jersey

ABSTRACT Jivoff, P.R. ; Moritzen, L. ; Kels, J.; McCarthy, J.; Young, A. ; Barton, A. ; Ferdinando, P.; Pandolfo, F. , and Tighe, C. , 2017. The relative importance of the Sedge Island Marine Conservation Zone for adult blue crabs in Barnegat Bay, New Jersey. In: Buchanan, G.A. ; Belton, T.J., and Paudel, B. (eds.), A Comprehensive Assessment of Barnegat Bay-Little Egg Harbor, New Jersey. Marine protected areas have become an important tool for the management of commercially important species. The Sedge Island Marine Conservation Zone (SIMCZ) in Barnegat Bay is 15 years old, but its effectiveness has never been assessed. This study evaluated the relative importance of the SIMCZ for adult blue crabs by comparing the abundance and size frequency distribution of crabs inside the SIMCZ with physically similar locations outside the SIMCZ that (1) were nearby, providing straight-line access to Barnegat Inlet but varying in habitat, and (2) varied in distance from an inlet but shared the same habitat. The SIMCZ contained more ovigerous females than surrounding locations, but there were few other differences, probably because of variation in habitats. Compared with other submerged aquatic vegetation (SAV)–dominated areas, the SIMCZ contained more legal-sized males. One potential effect of the lack of commercial fishing inside the SIMCZ may be a preponderance of relatively large males. The SIMCZ also contained more females, especially ovigerous females, even compared with adjacent SAV-dominated areas with similar proximity to Barnegat Inlet. Taken together, these results suggest that the SIMCZ is unique as an SAV-dominated area important for adult male and female blue crabs, particularly females that are members of the current spawning stock.
Remedies for Information Asymmetry in Online Transaction: An Investigation into the Impact of Web Page Signals on Auction Outcome

Purpose – This study seeks to investigate the signals on which consumers may rely to reduce the problems of information asymmetry on an online auction site. The research aims to develop and test based on information signaling theory. It classifies signals from auction web pages into three types: seller reputation, product condition, and argument quality. To understand how the signals affect consumers' online buying decisions, the study intends to test the impacts of these signals on the auction outcome variables: number of bids, auction success, and willingness to pay.Design/methodology/approach – The paper employs an empirical test with real observation data comprised of 5,013 samples coded from the eBay auction site in the USA. Ordinary least squares (OLS) regression is used to predict the effect of web page signals on the number of bids, logistic regression to determine which web page signals contribute to auction success, and Tobit maximum likelihood estimation to estimate the impact of web page signa.
Reproductive characters of senduro goat at lumajang district east java

Senduro goat is native local animals of Lumajang District East Java, Indonesia. These goats are considered as a potential new genetic resource for both milk and meat that has been declared as new breed Indonesia goat at 2014. The character of Senduro goat was identic with Etawah crossbreed (PE), because it was selected from PE by the farmer group and Senduro breeding association. The aims of this research were characterized reproductive characters of adult female Senduro goat existing in smallholder farm. The location of the study was carried out purposively in 6 villages in Senduro sub-district, Lumajang. It used 155 adult Senduro goats. The results showed that the average litter size was 1.83 + 0.69 per parent, while the kidding interval was 281.87 + 37.66 days. The mortality rate of Senduro goats was considered low, at 4.93%. So, the reproductive performance is deemed to be low. The incidence of single births was 32.45%, while multiple births reached 67.55%, where the twin births type were the highest achieving 55.62%. Reproduction character or performance based on litter size and kidding interval is categorized as a low category, it needs to be improved so that it has better reproductive performance and productivity.
The Sequence of a 1.8-Mb Bacterial Linear Plasmid Reveals a Rich Evolutionary Reservoir of Secondary Metabolic Pathways

Plasmids are mobile genetic elements that play a key role in the evolution of bacteria by mediating genome plasticity and lateral transfer of useful genetic information. Although originally considered to be exclusively circular, linear plasmids have also been identified in certain bacterial phyla, notably the actinomycetes. In some cases, linear plasmids engage with chromosomes in an intricate evolutionary interplay, facilitating the emergence of new genome configurations by transfer and recombination or plasmid integration. Genome sequencing of Streptomyces clavuligerus ATCC 27064, a Gram-positive soil bacterium known for its production of a diverse array of biotechnologically important secondary metabolites, revealed a giant linear plasmid of 1.8 Mb in length. This megaplasmid (pSCL4) is one of the largest plasmids ever identified and the largest linear plasmid to be sequenced. It contains more than 20% of the putative protein-coding genes of the species, but none of these is predicted to be essential for primary metabolism. Instead, the plasmid is densely packed with an exceptionally large number of gene clusters for the potential production of secondary metabolites, including a large number of putative antibiotics, such as staurosporine, moenomycin, β-lactams, and enediynes. Interestingly, cross-regulation occurs between chromosomal and plasmid-encoded genes. Several factors suggest that the megaplasmid came into existence through recombination of a smaller plasmid with the arms of the main chromosome. Phylogenetic analysis indicates that heavy traffic of genetic information between Streptomyces plasmids and chromosomes may facilitate the rapid evolution of secondary metabolite repertoires in these bacteria.
Reducing High-Dimensional Data by Principal Component Analysis vs. Random Projection for Nearest Neighbor Classification

The computational cost of using nearest neighbor classification often prevents the method from being applied in practice when dealing with high-dimensional data, such as images and micro arrays. One possible solution to this problem is to reduce the dimensionality of the data, ideally without loosing predictive performance. Two different dimensionality reduction methods, principle component analysis (PCA) and random projection (RP), are investigated for this purpose and compared w.r. t. the performance of the resulting nearest neighbor classifier on five image data sets and five micro array data sets. The experiment results demonstrate that PCA outperforms RP for all data sets used in this study. However, the experiments also show that PCA is more sensitive to the choice of the number of reduced dimensions. After reaching a peak, the accuracy degrades with the number of dimensions for PCA, while the accuracy for RP increases with the number of dimensions. The experiments also show that the use of PCA and RP may even outperform using the non-reduced feature set (in 9 respectively 6 cases out of 10), hence not only resulting in more efficient, but also more effective, nearest neighbor classification
Coeliac disease: in vivo toxicity of the putative immunodominant epitope

Background: Peptides from α-gliadins have been used to characterise the immunodominant coeliac toxic epitope. A peptide corresponding to amino acid residues 57–73 of A-gliadin causes peripheral blood mononuclear cells from coeliac patients to secrete interferon γ (IFN-γ); gluten specific small intestinal T cell clones proliferate in response to peptides corresponding to residues 57–68 and 62–75 of α-gliadins. We wished to investigate whether a peptide corresponding to residues 56–75 of α-gliadins exacerbates coeliac disease in vivo. Methods: Four adults with coeliac disease, all of whom were on a gluten free diet, underwent three challenges. Peptic-tryptic gliadin (PTG 1 g) served as a positive control. The test peptide and a negative control peptide were studied on separate occasions. The peptides were instilled into the duodenum and biopsies were taken before the infusion, and two, four, and six hours after commencing the infusions, using a Quinton hydraulic multiple biopsy capsule. Biopsy specimens were assessed blindly for villus height to crypt depth ratio (VH:CD), enterocyte cell height (ECH), and intraepithelial lymphocyte (IEL) count. We used the Mann-Whitney U test, with 95% confidence intervals, for statistical analysis. Results: VH:CD and ECH fell, and IEL increased significantly 4–6 hours after commencing infusions with both PTG and the test peptide in all subjects. The negative control peptide caused no significant changes to villus morphology, enterocyte height, or IEL count in any patient. Conclusion: We have confirmed that the putative immunodominant epitope, a peptide corresponding to residues 56–75 of α-gliadins, exacerbates coeliac disease in vivo.
Perceived social support among HIV patients newly enrolled in care in rural Ethiopia

ABSTRACT Social support significantly enhances physical and mental health for persons with human immunodeficiency virus (HIV). We surveyed 142 rural Ethiopian HIV patients newly enrolled in care for perceived social support and factors associated with low support levels. Using the Social Provisions Scale (SPS), the mean summary score was 19.1 (possible scores = 0–48). On six SPS subscales, mean scores (possible scores = 0–8), were: Reliable Alliance (others can be counted on for tangible assistance) = 2.8, Attachment (emotional closeness providing sense of security) = 2.9, Reassurance of Worth (recognition of competence and value by others) = 3.2, Guidance (provision of advice or information by others) = 3.2, Social Integration (belonging to a group with similar interests and concerns) = 3.5, and Nurturance (belief that others rely on one for their well-being) = 3.6. In multivariate analysis, factors significantly associated with lower social support scores were: lower education level (did not complete primary school) (p = .019), lower total score on knowledge items about HIV care/treatment (p = .038), and greater number of external stigma experiences in past three months (p < .001); greater number of chronic disease symptoms was of borderline significance (p = .098). Among rural Ethiopian patients newly entering HIV care, we found moderate and varying levels of perceived social support, with lowest scores for subscales reflecting emotional closeness and reliance on others for tangible assistance. Given that patients who have recently learned their diagnosis and entered care may be an especially vulnerable group, programs to help identify and address social support needs can provide multiple benefits in facilitating the best possible physical, emotional and functional quality of life for people living with HIV.
Detecting Stance in Tweets And Analyzing its Interaction with Sentiment

One may express favor (or disfavor) towards a target by using positive or negative language. Here for the first time we present a dataset of tweets annotated for whether the tweeter is in favor of or against pre-chosen targets, as well as for sentiment. These targets may or may not be referred to in the tweets, and they may or may not be the target of opinion in the tweets. We develop a simple stance detection system that outperforms all 19 teams that participated in a recent shared task competition on the same dataset (SemEval-2016 Task #6). Additionally, access to both stance and sentiment annotations allows us to conduct several experiments to tease out their interactions. We show that while sentiment features are useful for stance classification, they alone are not sufficient. We also show the impacts of various features on detecting stance and sentiment, respectively.
Companion cropping with potato onion enhances the disease resistance of tomato against Verticillium dahliae

Intercropping could alleviate soil-borne diseases, however, few studies focused on the immunity of the host plant induced by the interspecific interactions. To test whether or not intercropping could enhance the disease resistance of host plant, we investigated the effect of companion cropping with potato onion on tomato Verticillium wilt caused by Verticillium dahliae (V. dahliae). To investigate the mechanisms, the root exudates were collected from tomato and potato onion which were grown together or separately, and were used to examine the antifungal activities against V. dahliae in vitro, respectively. Furthermore, RNA-seq was used to examine the expression pattern of genes related to disease resistance in tomato companied with potato onion compared to that in tomato grown alone, under the condition of infection with V. dahliae. The results showed that companion cropping with potato onion could alleviate the incidence and severity of tomato Verticillium wilt. The further studies revealed that the root exudates from tomato companied with potato onion significantly inhibited the mycelia growth and spore germination of V. dahliae. However, there were no significant effects on these two measurements for the root exudates from potato onion grown alone or from potato onion grown with tomato. RNA-seq data analysis showed the disease defense genes associated with pathogenesis-related proteins, biosynthesis of lignin, hormone metabolism and signal transduction were expressed much higher in the tomato companied with potato onion than those in the tomato grown alone, which indicated that these defense genes play important roles in tomato against V. dahliae infection, and meant that the disease resistance of tomato against V. dahliae was enhanced in the companion copping with potato onion. We proposed that companion cropping with potato onion could enhance the disease resistance of tomato against V. dahliae by regulating the expression of genes related to disease resistance response. This may be a potential mechanism for the management of soil-borne plant diseases in the intercropping system.
Effect of short-term heat acclimation training on kinetics of lactate removal following maximal exercise.

BACKGROUND Heat acclimation (HA) evokes numerous physiological adaptations, improves heat tolerance and has also been shown to enhance lactate (LA) responses during exercise, similar to that seen with endurance training. The purpose of this study was to examine whether HA improves the body's ability to remove LA during recovery following maximal exercise. METHODS Ten healthy men completed two trials of maximal treadmill exercise (pre- and post-HA) separated by 5 days of HA. Each day of HA consisted of two 45 minute periods of cycling at ~50% VO2max separated by a 15min rest period in an environmental chamber (T(db) 45° C, RH 20%). In pre-/post-HA trials, venous blood was collected during 60 minutes of recovery to determine LA concentrations and removal kinetics (A2: amplitude and y2: velocity constant) using bi-exponential curve fitting. RESULTS Physiological adaptation to heat was significantly developed during HA, as evidenced by end-exercise T(re) (DAY1 vs. 5) (38.89±0.56 vs. 38.66±0.44° C), T(sk) (38.07±0.51 vs. 37.66±0.48° C), HR (175.0±9.9 vs. 165.0±18.5 beats·min(-1)), and sweat rate (1.24 ±.26 vs. 1.47 ±0.27 L·min(-1)) (P<0.05). However, there was no significant difference in either LA concentrations (LA(0min): 8.78±1.08 vs. 8.69±1.23; LA(peak): 10.97±1.77 vs. 10.95±1.46; and La(60min); 2.88±0.82 vs. 2.96±0.93 mmol·L(-1)) or removal kinetics (A2: -13.05±7.05 vs -15.59±7.90 mmol.L(-1) and y2: 0.02±0.01 vs. 0.03±. 01 min(-1)). CONCLUSIONS The present study concluded that, while effective in inducing thermo-physiological adaptations to heat stress, short-term HA does not improve the body's ability to remove LA following maximal exercise. Therefore, athletes and workers seeking faster LA recovery from intense physical activity may not benefit from short-term HA.