Miracle-dz/UniFAR-FTUs huggingface dataset:
Crowdsourcing-based radio map update automation for wi-fi positioning systems

With the popularization of smartphones, the needs for indoor location information are rapidly growing these days. Wi-Fi based positioning technique has been widely used to provide positioning information indoors. In particular, fingerprint-based localization is preferred because of its advantage in accuracy. However, the accuracy of localization gradually degrades as the Wi-Fi environment changes. In order to prevent the accuracy degradation, a radio map, which stores the Wi-Fi environment information, should be updated to accommodate the changes. Recalibration is commonly used to update a radio map, but it usually requires considerable time and effort. In this paper, we propose a method that can update the radio map automatically by using fingerprints collected from numerous users. In order to tag the locations of the collected fingerprints more accurately, the data from various sensors such as accelerometer and gyroscope are used. The proposed method also uses optimization algorithms along with a filtering method to remove erroneous data. The evaluation results showed that the accuracy achieved by the method was comparable to that of manual calibration in spite of using user feedback data. This indicates that without recalibration, the fingerprint-based indoor positioning system can keep up its accuracy if it is used by many users.
Real-time randomized path planning for robot navigation

Mobile robots often must find a trajectory to another position in their environment, subject to constraints. This is the problem of planning a path through a continuous domain Rapidly-exploring random trees (RRTs) are a recently developed representation on which fast continuous domain path planners can be based. In this work, we build a path planning system based on RRTs that interleaves planning and execution, first evaluating it in simulation and then applying it to physical robots. Our planning algorithm, ERRT (execution extended RRT), introduces two novel extensions of previous RRT work, the waypoint cache and adaptive cost penalty search, which improve replanning efficiency and the quality of generated paths. ERRT is successfully applied to a real-time multi-robot system. Results demonstrate that ERRT is significantly more efficient for replanning than a basic RRT planner, performing competitively with or better than existing heuristic and reactive real-time path planning approaches. ERRT is a significant step forward with the potential for making path planning common on real robots, even in challenging continuous, highly dynamic domains.
Genistein decreases cellular redox potential, partially suppresses cell growth in HL-60 leukemia cells and sensitizes cells to γ-radiation-induced cell death

Various mechanisms have been proposed to underlie the cellular activity of genistein, based on biological experiments and epidemiological studies. The present study demonstrated that genistein inhibited the expression of cytoplasmic nicotinamide adenine dinucleotide phosphate (NADP)-dependent isocitrate dehydrogenase (cICDH), thus increasing levels of intracellular reactive oxygen species (ROS) in human promyeloid leukemia HL-60 cells. In genistein-treated cells, the cellular redox potential (GSH/GSSG) was significantly decreased. This decrease in redox potential was caused by significant downregulation of the cICDH gene, generating the reducing equivalents (NADPH) for maintenance of cellular redox potential and cellular ROS level, which may regulate cell growth and cell death. Genistein-induced ROS partially induced rapid transition into the G2/M phase by upregulation of p21wap1/cip1 and apoptotic cell death. Treatment of cells with N-acetylcysteine, a well-known antioxidant (ROS scavenger), not only partially restored cell growth and inhibited cell cycle arrest in G2/M, but also prevented apoptotic cell death. By contrast, normal lymphocytes did not significantly progress into the G2/M phase and radiation-induced cell death was inhibited by genistein treatment. Therefore, genistein and γ-irradiation together synergistically cause cell death in leukemia cells, however, genistein has a radioprotective effect in normal human lymphocytes. In conclusion, it was suggested that genistein selectively functions, not as an antioxidant, but as a pro-oxidant in HL-60 cells. This property can increase ionizing radiation-induced cell cycle arrest and sensitivity to apoptotic cell death in human promyeloid leukemia HL-60 cells, but does not cause significant damage to normal cells.
Trauma-informed medical care: CME communication training for primary care providers.

BACKGROUND AND OBJECTIVES Trauma exposure predicts mental disorders, medical morbidity, and health care costs. Yet trauma-related impacts have not received sufficient attention in primary care provider (PCP) training programs. This study adapted a theory-based approach to working with trauma survivors, Risking Connection, into a 6-hour CME course, Trauma-Informed Medical Care (TI-Med), and evaluated its efficacy. METHODS We randomized PCPs to training or wait-list (delay) conditions; wait-list groups were trained after reassessment. The primary outcome assessing newly acquired skills was a patient-centeredness score derived from Roter Interactional Analysis System ratings of 90 taped visits between PCPs and standardized patients (SPs). PCPs were family medicine residents (n=17) and community physicians (n=13, 83% family medicine specialty), from four sites in the Washington, DC metropolitan area. RESULTS Immediately trained PCPs trended toward a larger increase in patient centeredness than did the delayed PCPs, with a moderate effect size (.66). The combined trained PCP groups showed a significant increase in patient centeredness from before to after training. CONCLUSIONS This is a promising approach to supporting relationship-based trauma-informed care among PCPs to help promote better patient health and higher compliance with medical treatment plans.
Protein digestion in the intestine of sheep

1. The rate of flow of digesta along the intestinal tract, and particularly the changes occurring in proteins during their passage through the intestine were determined in six rams; each animal was fistulated with three cannulas which involved six different sites of the intestine. Cr2O3 was used as a marker substance to measure the rate of flow of the digesta. 2. In the sections of the intestine from 1 to 15 m posterior to the pylorus the amounts of water, dry matter and total nitrogen decreased gradually as a result of their absorption through the intestinal wall. The region of the intestine situated at a distance of 7–15 m from the pylorus was more active with respect to the absorption of N, whereas water and dry matter were adsorbed to a greater extent in the region from 1 to 7 m from the pylorus. 3. The only part of the intestine in which substantial increases of water, dry matter and total N were found was the section immediately distal to the pylorus, and these increases were caused by the inflow of bile, and pancreatic and duodenal juices. The net increase found beyond the entry of the common bile duct was 2.7 g protein N and 2.0 g non-protein N (NPN)/24 h. 4. The activities of trypsin, chymotrypsin and carboxypeptidase A and the ratio α-NH2 NPN: protein N increased from the pylorus up to a distance of 7 m and decreased again from this point to a distance of 15 m from the pylorus. 5. In the sections of the intestine between 1 and 3 and between 3 and 7 m distant from the pylorus the extent of proteolysis exceeded considerably that of absorption of amino acids through the intestinal wall. This was concluded from the decrease in the rate of flow of protein amino acids (by 31% between 1 and 3 m distant from the pylorus and by 34% between 3 and 7 m) and the simultaneous increase in non-protein amino acids (by 20% in the region between 1 and 3 m) or no change in non-protein amino acids (between 3 and 7 m). 6. The relatively greater decrease in non-protein amino acids (by 57%) compared with that of protein amino acids (by 41%) occurring in the section 7 to 15 m distant from the pylorus showed that this is an area of most intensive absorption of amino acids. 7. In the lower section of the intestine, from 15 to 25 m distant from the pylorus, the total amount of amino acids showed almost no change; probably a net effect of loss and gain of amino acids mainly due to microbial activities. Increases in the dehydrogenase activity suggested enhancement of bacterial activity in this lower region of the intestine. 8. The supply of essential amino acids to the tissues of sheep is improved, compared with the amino acid composition of the diet, as the result of ruminal biosynthesis of essential amino acids and ruminal degradation of non-essential amino acids and preferential absorption of essential amino acids through the intestinal wall, particularly in the section of most intensive absorption, 7–15 m distant from the pylorus.
Applications of p53 interactome analysis to personalised drug discovery

The stress responsive transcription factor p53 is a powerful tumor suppressor implicated in over 50 % of all human cancers. The complexity and nonlinear dynamics of p53 network coupled with extensive literature is challenging. Sys-tems biology methodologies offer promising tools to investigate perturbed net-works, providing structured in silico representations for integrative analysis. The Boolean p53 interactome (PKT206) incorporates the diverse p53 information into a comprehensible framework, and demonstrated good predictive ratios (51 – 75%) using logical steady state analysis. Whilst extensive, Boolean models provide only a qualitative approximation of the system. A prerequisite of diseased in silico models is to accurately represent biological phenomena to characterize network perturbations for effective drug candidates. Thus a quanti-tative approach is necessitated. We have applied a novel signal transduction al-gorithm (STSFA) to PKT206 for model performance and comparison. The STSFA quantitatively analyses large scale ‘omics’ data, typically not accessible with large networks. STFSA in silico simulations of DNA damage and p53 knock out were accurately predicted compared to various gene expression pro-files (P = <1x10-16), and was consistently more accurate than LSSA, generating a significantly higher proportion of correct predictions (P = 0.003). Furthermore, genes CKS2, WWP1, EPHB4 were identified as prospective drug candidates by in silico knockout analysis. In summary, refinement of Boolean PKT206 using STFSA has provided a semi quantitative view of the p53 interactome, and along with the use of ‘omics’ data, may be of greater clinical relevance for identification of perturbed pathways and personalized therapies by superimposition of individual genomic profiles.
A BICM-IDD scheme for non-coherent MIMO communication

A bit-interleaved coded modulation (BICM) scheme with iterative (soft) demapping and decoding (IDD) is developed for non-coherent communication over a multiple-input multiple-output (MIMO) channel. The scheme exploits the underlying Grassmannian geometry of the signalling scheme that approaches the ergodic capacity of the non-coherent model at high signal-to-noise ratios. In particular, this geometry guides the construction of the constellation and the mapper at the transmitter, and gives rise to a computationally-efficient list-based demapping algorithm. The incorporation of a scheme that enables the decoder to augment the demapping list virtually eliminates the mild performance degradation of the efficient demapper. Simulation results demonstrate that at high data rates the proposed scheme can provide significantly better performance than several training-based BICM-IDD schemes.
Managing Environmental Knowledge through Learning Processes in Spanish Hospitality Companies

The major focus of this research is to investigate whether environmental knowledge has any impact on organizational outcomes through an empirical investigation of 127 Spanish hospitality companies, using structural equation models. Our results show that environmental knowledge is an important determiner for developing organizational outcomes. However, this relationship is completed with just two related constructs: Firstly, the company's acquisition process plays a key role in managing the tension between the knowledge necessary to develop the appropriated environmental initiatives and current knowledge. Secondly, the company's distribution process also sheds light on tangible means for managers to enhance their company's outcomes through environmental knowledge. El objetivo principal de esta investigación es analizar mediante ecuaciones estructurales aplicadas a 127 empresas del sector español de la hospitalidad, si el conocimiento ambiental ejerce algún impacto en los resultados empresariales. Nuestros resultados muestran que el conocimiento ambiental ejerce un papel importante para alcanzar los objetivos entre las empresas objeto de estudio. Sin embargo, este papel se encuentra condicionado a la presencia de dos dimensiones más que actúan de forma complementaria. En primer lugar, el proceso de adquisición de conocimiento juega un papel clave para lidiar la tensión entre el conocimiento necesario para impulsar las iniciativas ambiéntales demandadas y el conocimiento actual disponible. En segundo lugar, el proceso de distribución también posibilitad medidas palpables y realizables para que los directivos puedan mejorar sus resultados a través del conocimiento ambiental.
Secure Attachment Conceptualizations:

Attachment theory focuses on the cognitive models that underlie our interactions with attachment figures. Global or generalized mental models are thought to develop on the basis of attachment models with parents and might form the initial basis of internal working models in novel relationships. However, as discrepant information presents itself in a new relationship, it is thought that specific relational models develop. When conflict arises it can threaten the attachment bonds of the relationship. An Internet survey of 134 individuals in couple relationships was conducted to test the influence of secure parental and partner attachment conceptualizations on romantic relationship variables (conflict beliefs and conflict resolution styles). Results indicated that for the most part relationship variables were influenced by current secure romantic attachment conceptualizations. Analyses also indicated differential gender results for positive problem solving in terms of secure parental and partner attachment. Secure parental attachment was also found to impact on the report of compliant behavior during conflict resolution. Lastly, the belief that arguing is threatening was found to be impacted by an interaction effect between parental and partner attachment. In general secure partner attachment was more predictive of conflict resolution behavior and conflict beliefs, than a global attachment model. However, it would appear that the global attachment model can be activated in the context of the current relationship under certain conditions. This research lends support to the notion that generalized and specific attachment representations impacts differently on close relationship functioning, and encourages a further mapping of relationship functions in this regard.
Antirenin immunization versus angiotensin converting enzyme inhibition in rats.

The effects of specific active immunization against renin were compared with those of chronic angiotensin converting enzyme (ACE) inhibition. Male spontaneously hypertensive rats (SHR) were immunized (SHR-I) (n = 10) against pure murine renin (four injections of 30 micrograms/kg s.c.) or received (SHR-P) (n = 11) a converting enzyme inhibitor (perindopril, 2 mg/kg/day per os for 4 weeks). Sham-immunized SHR (SHR-S) (n = 12) and normotensive Wistar-Kyoto (WKY-S) (n = 12) rats served as controls. At 15 weeks of age, 24-hour average blood pressure was obtained in freely moving rats using intra-aortic pressure recording with computer analysis. Antirenin immunization induced high circulating titers of antibodies, a fall in plasma renin activity (-95%), and urinary excretion of mineralocorticoids. Perindopril abolished the pressor response to angiotensin I, whereas plasma ACE was only partly (-56%) decreased. It also increased plasma renin activity and did not alter the urinary excretion of steroids. Both immunization and perindopril allowed the blood pressure of SHR to return to the level of WKY-S rats and reduced the left ventricular weight. These decreases were associated with an elevated sympathetic nervous system activity as indicated by increases in the urinary excretion of catecholamines and their metabolites. It is conclude that, apart from an unaltered steroid synthesis, most of the cardiovascular effects of chronic ACE inhibition are similar to those of antirenin immunization, thus indicating that blockade of the circulating and renal renin-angiotensin system accounts for most of the effects of ACE inhibitors.
Nondistorting flattening maps and the 3-D visualization of colon CT images

Considers a novel three-dimensional (3-D) visualization technique based on surface flattening for virtual colonoscopy. Such visualization methods could be important in virtual colonoscopy because they have the potential for noninvasively determining the presence of polyps and other pathologies. Further, the authors demonstrate a method that presents a surface scan of the entire colon as a cine, and affords the viewer the opportunity to examine each point on the surface without distortion. The authors use certain angle-preserving mappings from differential geometry to derive an explicit method for flattening surfaces obtained from 3-D colon computed tomography (CT) imagery. Indeed, the authors describe a general method based on a discretization of the Laplace-Beltrami operator for flattening a surface into the plane in a conformal manner. From a triangulated surface representation of the colon, the authors indicate how the procedure may be implemented using a finite element technique, which takes into account special boundary conditions. They also provide simple formulas that may be used in a real-time cine to correct for distortion.
Cracking tendency of self-compacting concrete subjected to restrained shrinkage : Experimental study and modeling

This paper presents a study on cracking risk due to shrinkage of self-compacting concrete (SCC). Cracking of SCC was investigated through a comparison of material properties, such as shrinkage, modulus of elasticity, creep, and fracture parameters, between SCC mixtures and ordinary concrete (OC) mixtures. Restrained shrinkage tests (ring tests) were also performed on the same mixtures. Numerical simulations were then used to assess the correlation between material properties and results of restrained shrinkage tests. SCC and OC were found to have equivalent shrinkage cracking tendency, provided that compressive strength is kept the same and that SCC has adequate segregation resistance.
NIHAO project II: Halo shape, phase-space density and velocity distribution of dark matter in galaxy formation simulations

We use the NIHAO (Numerical Investigation of Hundred Astrophysical Objects) cosmological simulations to study the effects of galaxy formation on key properties of dark matter (DM) haloes. NIHAO consists of ≈90 high-resolution smoothed particle hydrodynamics simulations that include (metal-line) cooling, star formation, and feedback from massive stars and supernovae, and cover a wide stellar and halo mass range: 10^6 ≲ M^*/M_⊙ ≲ 10^(11)(10^(9.5) ≲ M_(halo)/M_⊙ ≲ 10^(12.5)). When compared to DM-only simulations, the NIHAO haloes have similar shapes at the virial radius, R_(vir), but are substantially rounder inside ≈0.1Rvir. In NIHAO simulations, c/a increases with halo mass and integrated star formation efficiency, reaching ∼0.8 at the Milky Way mass (compared to 0.5 in DM-only), providing a plausible solution to the long-standing conflict between observations and DM-only simulations. The radial profile of the phase-space Q parameter (ρ/σ^3) is best fit with a single power law in DM-only simulations, but shows a flattening within ≈0. 1R_(vir) for NIHAO for total masses M > 10^(11) M_⊙. Finally, the global velocity distribution of DM is similar in both DM-only and NIHAO simulations, but in the solar neighbourhood, NIHAO galaxies deviate substantially from Maxwellian. The distribution is more symmetric, roughly Gaussian, with a peak that shifts to higher velocities for Milky Way mass haloes. We provide the distribution parameters which can be used for predictions for direct DM detection experiments. Our results underline the ability of the galaxy formation processes to modify the properties of DM haloes.
Chunk‐based and fairness‐based resource allocation in multicast distributed MISO‐OFDMA systems

The resource allocation problem for the downlink of orthogonal frequency‐division multiple access (OFDMA) wireless multicast systems is investigated. It is assumed that the base station consists of multiple antennas in a distributed antenna system (DAS), whereas each user is equipped with a single antenna. The multicasting technology is able to support several groups of users with flexible quality of service (QoS) requirements. The general mathematical formulation is provided, but achieving the optimal solution has a high computational cost. In our approach, the allocation unit is not the subcarrier, as in conventional OFDMA systems, but a set of contiguous subcarriers, which is called ‘chunk’. For practical implementation, a suboptimal but efficient algorithm is proposed in order to maximize the sum of the maximum attainable data rates of multicast groups of users, subject to total available power and proportional maximum attainable data rate constraints among multicast groups of users. Simulation and complexity analyses are provided to support the benefits of chunk‐based resource allocation to multicast OFDMA DASs, supporting that the proposed algorithm can be applied to latest‐generation wireless systems that provide QoS guarantees. Copyright © 2013 John Wiley & Sons, Ltd.
Linking HIV-Infected TB Patients to Cotrimoxazole Prophylaxis and Antiretroviral Treatment in India

Background HIV-infected persons suffering from tuberculosis experience high mortality. No programmatic studies from India have documented the delivery of mortality-reducing interventions, such as cotrimoxazole prophylactic treatment (CPT) and antiretroviral treatment (ART). To guide TB-HIV policy in India we studied the effectiveness of delivering CPT and ART to HIV-infected persons treated for tuberculosis in three districts in Andhra Pradesh, India, and evaluated factors associated with death. Methods and Findings We retrospectively abstracted data for all HIV-infected tuberculosis patients diagnosed from March 2007 through August 2007 using standard treatment outcome definitions. 734 HIV-infected tuberculosis patients were identified; 493 (67%) were males and 569 (80%) were between the ages of 24–44 years. 710 (97%) initiated CPT, and 351 (50%) collected >60% of their monthly cotrimoxazole pouches provided throughout TB treatment. Access to ART was documented in 380 (51%) patients. Overall 130 (17%) patients died during TB treatment. Patients receiving ART were less likely to die (adjusted hazard ratio [HR] 0.4, 95% confidence interval [CI] 0.3–0.6), while males and those with pulmonary TB were more likely to die (HR 1.7, 95% CI 1.1–2.7, and HR 1.9, 95% CI 1.1–3.2 respectively). Conclusions Among HIV-infected TB patients in India death was common despite the availability of free cotrimoxazole locally and ART from referral centres. Death was strongly associated with the absence of ART during TB treatment. To minimize death, programmes should promote high levels of ART uptake and closely monitor progress in implementation.