Miracle-dz/UniFAR-FTUs huggingface dataset:
Copper cementation on nickel discs

AbstractThe cementation of copper on various types of nickel discs has been studied in dilute cupric sulphate solutions. Activation of the cathode nickel discs with Te+4 was necessary to achieve reproducible rates, whereas satisfactory results were obtained with mint nickel discs using only a chemical polishing treatment Attempts to cement copper on discs of nickel-copper alloys were unsuccessful.The cementation process on pure nickel takes place by two different rate-controlling mechanisms. At low temperatures the process is probably controlled by a surface reaction, whereas at higher temperatures the process is probably controlled by diffusion through surface layers. When the acidify of the solution is increased, the cementation rate increases. The rate decreases with increasing thickness of the cemented deposit. Resume Le depot de cuivre sur divers types de disques de nickel a ete etudie en solution diluee de sulfate cuivrique. Afin d'obtenir des taux reproductibles il a ete necessaire d'activer les di.
Effect of Diet and Exercise on the Peripheral Immune System in Young Balb/c Mice

Although diet and exercise clearly have an influence on immune function, studies are scarce on the effect caused by exercise and the consumption of a carbohydrate-rich or fat-rich diet on the peripheral immune system. The aim of the present study was to evaluate the effect of exercise and the two aforementioned unbalanced diets on young Balb/c mice, especially in relation to BMI, the level of glucose, and the percentage of lymphocyte subpopulations in peripheral blood. The changes found were then related to the synthesis of leptin and adiponectin as well as the production of oxidative stress. The increase in BMI found with the carbohydrate-rich and fat-rich diets showed correlation with the levels of leptin and adiponectin. An increase in leptin and a decrease in adiponectin directly correlated with an increase in total lymphocytes and CD4+ cells and with a decrease in B cells. The increase in leptin also correlated with an increase in CD8+ cells. Glycemia and oxidative stress increased with the two unbalanced diets, negatively affecting the proliferation of total lymphocytes and the percentage of B cells, apparently by causing alterations in proteins through carbonylation. These alterations caused by an unbalanced diet were not modified by moderate exercise.
Modulation of the extent of structural heterogeneity in α-synuclein fibrils by the small molecule thioflavin T

The transition of intrinsically disordered, monomeric α-synuclein into β-sheet–rich oligomers and fibrils is associated with multiple neurodegenerative diseases. Fibrillar aggregates possessing distinct structures that differ in toxicity have been observed in different pathological phenotypes. Understanding the mechanism of the formation of various fibril polymorphs with differing cytotoxic effects is essential for determining how the aggregation reaction could be modulated to favor nontoxic fibrils over toxic fibrils. In this study, two morphologically different α-synuclein fibrils, one helical and the other ribbon-like, are shown to form together. Surprisingly, a widely used small molecule for probing aggregation reactions, thioflavin T (ThT), was found to tune the structural heterogeneity found in the fibrils. The ribbon-like fibrils formed in the presence of ThT were found to have a longer structural core than the helical fibrils formed in the absence of ThT. The ribbon-like fibrils are also more toxic to cells. By facilitating the formation of ribbon-like fibrils over helical fibrils, ThT reduced the extent of fibril polymorphism. This study highlights the role of a small molecule such as ThT in selectively favoring the formation of a specific type of fibril by binding to aggregates formed early on one of multiple pathways, thereby altering the structural core and external morphology of the fibrils formed.
Determining an Optimum Opening Roller Speed for Spinning Polyester/ Waste Blend Rotor Yarns

The opening roller, which is one of the three most important items in the OE rotor spinning system, influences yarn quality and spinning performance. In addition to the raw materials, roller speed and type are critical. In this work, seven different polyester/waste (cotton noil, recycled fibers, flat waste, etc.) rotor yams are produced at seven different opening roller speeds on a laboratory-type OE rotor spinning machine (Quickspin), and the influence of opening roller speed on yarn quality is examined. A high opening roller speed is recommended, while spinning waste content does not provide the expected results.
The Tensile and Fatigue Properties of Carbon Fiber-reinforced PEEK-Titanium Fiber-metal Laminates

This paper investigates the tensile and fatigue properties of a novel fiber-metal laminate (FML) based on a titanium alloy and carbon fiber-reinforced poly-ether-ether-ketone (PEEK). Tensile tests on unidirectional unnotched laminates have shown that their mechanical properties follow the predictions offered by a simple law of mixtures approach. Tension-tension fatigue tests on notched unidirectional FMLs have shown that these laminates offer fatigue lives up to fifty times greater than those offered by a notched monolithic titanium alloy. An examination of the failed FMLs highlighted the presence of delamination between the titanium alloy and the fiber-reinforced composite. The experimental evidence suggests that this form of damage is harmful during fatigue loading conditions. It has also been shown that delamination is more widespread in FMLs based on thick composite layers than in laminates containing thin composite layers.
Validation of the phenomenon of autistic regression using home videotapes.

CONTEXT To date, there has been no objective validation of the phenomenon of autistic regression early in life. OBJECTIVE To validate parental report of autistic regression using behavioral data coded from home videotapes of children with autism spectrum disorder (ASD) vs typical development taken at 12 and 24 months of age. DESIGN Home videotapes of 56 children's first and second birthday parties were collected from parents of young children with ASD with and without a reported history of regression and typically developing children. Child behaviors were coded by raters blind to child diagnosis and regression history. A parent interview that elicited information about parents' recall of early symptoms from birth was also administered. SETTING Participants were recruited from a multidisciplinary study of autism conducted at a major university. PARTICIPANTS Fifteen children with ASD with a history of regression, 21 children with ASD with early-onset autism, and 20 typically developing children and their parents participated. MAIN OUTCOME MEASURES Observations of children's communicative, social, affective, repetitive behaviors, and toy play coded from videotapes of the toddlers' first and second birthday parties. RESULTS Analyses revealed that infants with ASD with regression show similar use of joint attention and more frequent use of words and babble compared with typical infants at 12 months of age. In contrast, infants with ASD with early onset of symptoms and no regression displayed fewer joint attention and communicative behaviors at 12 months of age. By 24 months of age, both groups of toddlers with ASD displayed fewer instances of word use, vocalizations, declarative pointing, social gaze, and orienting to name as compared with typically developing 24-month-olds. Parent interview data suggested that some children with regression displayed difficulties in regulatory behavior before the regression occurred. CONCLUSION This study validates the existence of early autistic regression.
A comparison of methods of predicting maximum oxygen uptake.

The aim of this study was to compare the results from a Cooper walk run test, a multistage shuttle run test, and a submaximal cycle test with the direct measurement of maximum oxygen uptake on a treadmill. Three predictive tests of maximum oxygen uptake--linear extrapolation of heart rate of VO2 collected from a submaximal cycle ergometer test (predicted L/E), the Cooper 12 min walk, run test, and a multi-stage progressive shuttle run test (MST)--were performed by 22 young healthy males (mean(s.d.) age 22.1 (2.4) years; body mass 72.4(8.9kg)) and the values compared to those obtained by direct measurement on a maximal treadmill test. All of the subjects were regular exercisers. The mean(s.d.) from the various tests in ml.kg-1.min-1 were as follows: treadmill 60.1(8.0), Cooper 60.6(10.3), MST 55.6(8.0), and predictedL/E 52.0(8.4). The Cooper test had a correlation with the treadmill test of 0.92, while the MST and the predictedL/E had correlations of 0.86 and 0.76 respectively. Both the MST and predictedL/E showed systematic underprediction of the treadmill value. On average, the MST was 4.5 ml.kg-1.min-1 (s.e. 0.9) lower than the treadmill VO2max while the predictedL/E was 7.8 ml.kg-1. min-1 (s.e. 1.4) lower than the treadmill VO2max. These findings indicate that, for the population assessed, the Cooper walk run test is the best predictor of VO2max among the three tests.
Experimental Behavior of Concrete Columns Confined by Welded Wire Fabric as Transverse Reinforcement under Axial Compression

This study examines the behavior of normal-strength concrete short columns confined by welded wire fabric (WWF) as transverse reinforcement under monotonically increasing concentric compression. The authors investigate the effects of volumetric ratio, spacing and lateral steel configuration, and distribution of longitudinal steel around the core perimeter or longitudinal reinforcement ratio on the uniaxial behavior of reinforced concrete columns. Tests were conducted on 22 short concrete columns reinforced with longitudinal steel and WWF or conventional ties under axial compression. The performance of columns laterally reinforced with WWF was compared with that of columns laterally reinforced with conventional ties. The findings show that WWF can be effective in confining the core concrete. Ductility increases of 130% and strength increases of at least 17% were found when compared with the corresponding specimens with conventional ties. The ductility of confined concrete columns improved with an increase of longitudinal reinforcement and decrease of transverse reinforcement spacing. Welded grids reduced the congestion of reinforcement and improved concrete quality in the members.
Collision-minimizing CSMA and its applications to wireless sensor networks

Recent research in sensor networks, wireless location systems, and power-saving in ad hoc networks suggests that some applications' wireless traffic be modeled as an event-driven workload: a workload where many nodes send traffic at the time of an event, not all reports of the event are needed by higher level protocols and applications, and events occur infrequently relative to the time needed to deliver all required event reports. We identify several applications that motivate the event-driven workload and propose a protocol that is optimal for this workload. Our proposed protocol, named CSMA/p/sup */, is nonpersistent carrier sense multiple access (CSMA) with a carefully chosen nonuniform probability distribution p/sup */ that nodes use to randomly select contention slots. We show that CSMA/p/sup */ is optimal in the sense that p/sup */ is the unique probability distribution that minimizes collisions between contending stations. CSMA/p/sup */ has knowledge of N. We conclude with an exploration of how p/sup */ could be used to build a more practical medium access control protocol via a probability distribution with no knowledge of N that approximates p/sup */.
Phonological and orthographic cues enhance the processing of inflectional morphology. ERP evidence from L1 and L2 French

We report the results of two event-related potential (ERP) experiments in which Spanish learners of French and native French controls show graded sensitivity to verbal inflectional errors as a function of the presence of orthographic and/or phonological cues when reading silently in French. In both experiments, verbal agreement was manipulated in sentential context such that subject verb agreement was either correct, ill-formed and orally realized, involving both orthographic and phonological cues, or ill-formed and silent which involved only orthographic cues. The results of both experiments revealed more robust ERP responses to orally realized than to silent inflectional errors. This was true for L2 learners as well as native controls, although the effect in the learner group was reduced in comparison to the native group. In addition, the combined influence of phonological and orthographic cues led to the largest differences between syntactic/phonological conditions. Overall, the results suggest that the presence of phonological cues may enhance L2 readers’ sensitivity to morphology but that such may appear in L2 processing only when sufficient proficiency is attained. Moreover, both orthographic and phonological cues are used when available.
Extreme Halophiles Synthesize Betaine from Glycine by Methylation*

Glycine betaine is a compatible solute, which is able to restore and maintain osmotic balance of living cells. It is synthesized and accumulated in response to abiotic stress. Betaine acts also as a methyl group donor and has a number of important applications including its use as a feed additive. The known biosynthetic pathways of betaine are universal and very well characterized. A number of enzymes catalyzing the two-step oxidation of choline to betaine have been isolated. In this work we have studied a novel betaine biosynthetic pathway in two phylogenically distant extreme halophiles,Actinopolyspora halophila and Ectothiorhodospira halochloris. We have identified a three-step series of methylation reactions from glycine to betaine, which is catalyzed by two methyltransferases, glycine sarcosine methyltransferase and sarcosine dimethylglycine methyltransferase, with partially overlapping substrate specificity. The methyltransferases from the two organisms show high sequence homology. E. halochlorismethyltransferase genes were successfully expressed inEscherichia coli, and betaine accumulation and improved salt tolerance were demonstrated.
A finite element simulation of the cold working process for fastener holes

Two-dimensional axisymmetric finite element simulations have been conducted for the cold working of a fastener hole in an aluminium plate. The simulation models the actual cold working process where an oversize mandrel is pulled through the fastener hole. The results of the simulation are compared with a simplified finite element model where the cold working process is reduced to applying a uniform radial expansion to the hole edge. It is shown that substantial differences exist between the finite element simulations; specifically, the simulation of the actual process shows tensile residual radial stresses on the surface of the plate after cold working whereas the simplified simulation shows only compressive ones. Further comparisons are made for the axial deformation of the plate by using the results of an experimental measurement of the surface profile around a cold worked hole. There is good agreement between the finite element and experimental results. The results of this work show that accurate simulations of cold working are necessary if predicted residual stresses are to be used to assess fatigue life.
Haemophilia in the developing countries: the Iranian experience

Introduction Management of haemophilia and inherited bleeding disorders is a major challenge especially in developing countries, because of a shortage or absence of products, the cost and the infrastructural health problems. Development of local expertise which results in an improved outlook and reduction in mortality and morbidity in these countries can be helpful for advocators in other developing countries. However, very little information on demography and organizational models for haemophilia care in developing countries are available in the literature. Our aim is a comprehensive report of haemophilia status and its management in Iran. Material and methods The Management Center of Transplantation and Special Diseases (MCTSD) of the Ministry of Health of Iran decided to carry out a complete review and compilation of all of the published or available data about patients with haemophilia (PWH) in Iran: their health status, their management planning, organizations, treatment products, facilities and care problems during 2007. Results 6496 patients with congenital bleeding disorders were registered. Most of them had haemophilia A and B and von Willebrand disease (vWD). However, rare bleeding disorders are seen more than expected. Inhibitor development is 14–28%. There are different data about virological status of PWH. Factor products and facilities are fairly available with more than 1.5 units per capita of inhabitant factor consumption. Conclusions A national formulary based on facilities of the country should be considered and followed by collaboration among the Ministry Of Health, universities and non-governmental organizations.
System-wide Perturbation Analysis with Nearly Complete Coverage of the Yeast Proteome by Single-shot Ultra HPLC Runs on a Bench Top Orbitrap*

Yeast remains an important model for systems biology and for evaluating proteomics strategies. In-depth shotgun proteomics studies have reached nearly comprehensive coverage, and rapid, targeted approaches have been developed for this organism. Recently, we demonstrated that single LC-MS/MS analysis using long columns and gradients coupled to a linear ion trap Orbitrap instrument had an unexpectedly large dynamic range of protein identification (Thakur, S. S., Geiger, T., Chatterjee, B., Bandilla, P., Frohlich, F., Cox, J., and Mann, M. (2011) Deep and highly sensitive proteome coverage by LC-MS/MS without prefractionation. Mol. Cell Proteomics 10, 10.1074/mcp.M110. 003699). Here we couple an ultra high pressure liquid chromatography system to a novel bench top Orbitrap mass spectrometer (Q Exactive) with the goal of nearly complete, rapid, and robust analysis of the yeast proteome. Single runs of filter-aided sample preparation (FASP)-prepared and LysC-digested yeast cell lysates identified an average of 3923 proteins. Combined analysis of six single runs improved these values to more than 4000 identified proteins/run, close to the total number of proteins expressed under standard conditions, with median sequence coverage of 23%. Because of the absence of fractionation steps, only minuscule amounts of sample are required. Thus the yeast model proteome can now largely be covered within a few hours of measurement time and at high sensitivity. Median coverage of proteins in Kyoto Encyclopedia of Genes and Genomes pathways with at least 10 members was 88%, and pathways not covered were not expected to be active under the conditions used. To study perturbations of the yeast proteome, we developed an external, heavy lysine-labeled SILAC yeast standard representing different proteome states. This spike-in standard was employed to measure the heat shock response of the yeast proteome. Bioinformatic analysis of the heat shock response revealed that translation-related functions were down-regulated prominently, including nucleolar processes. Conversely, stress-related pathways were up-regulated. The proteomic technology described here is straightforward, rapid, and robust, potentially enabling widespread use in the yeast and other biological research communities.
Differentiation and replication of spots in a reaction-diffusion system with many chemicals

The replication and differentiation of spots in reaction-diffusion equations are studied by extending the Gray-Scott model with self-replicating spots to include many degrees of freedom needed to model systems with many chemicals. By examining many possible reaction networks, the behavior of this model is categorized into three types: replication of homogeneous fixed spots, replication of oscillatory spots, and differentiation from "multipotent spots" . These multipotent spots either replicate or differentiate into other types of spots with different fixed-point dynamics, and, as a result, an inhomogeneous pattern of spots is formed. This differentiation process of spots is analyzed in terms of the loss of chemical diversity and decrease of the local Kolmogorov-Sinai entropy. The relevance of the results to developmental cell biology and stem cells is also discussed.
NF‐κB‐dependent regulation of brain‐derived neurotrophic factor in hippocampal neurons by X‐linked inhibitor of apoptosis protein

X chromosome‐linked inhibitor of apoptosis protein (XIAP) is an anti‐apoptotic protein enhancing cell survival. Brain‐derived neurotrophic factor (BDNF) also promotes neuronal viability but the links between XIAP and BDNF have remained unclear. We show here that the overexpression of XIAP increases BDNF in transgenic mice and cultured rat hippocampal neurons, whereas downregulation of XIAP by silencing RNA decreased BDNF. XIAP also stimulated BDNF signaling, as shown by increased phosphorylation of the TrkB receptor and the downstream molecule, cAMP response element‐binding protein. The mechanism involved nuclear factor‐κB (NF‐κB) activation and blocking of NF‐κB signaling inhibited the increased activities of BDNF promoters I and IV by XIAP. In neuronal cultures XIAP also upregulated interleukin (IL)‐6, which is an NF‐κB‐responsive gene. The addition of IL‐6 elevated whereas incubation with IL‐6‐blocking antibodies reduced BDNF in the neurons. BDNF itself activated NF‐κB in the neurons at higher concentrations. The data show that XIAP has trophic effects on hippocampal neurons by increasing BDNF and TrkB activity. The results reveal a cytokine network in the brain involving BDNF, IL‐6 and XIAP interconnected via the NF‐κB system.
Monitoring and damping unbalanced magnetic pull due to eccentricity fault in induction machines: A review

Condition monitoring can diagnose the inception of fault mechanisms in induction motors, thus avoiding failure and expensive repairs. Therefore, there is a strong need to develop an efficient condition monitoring. The main target is to achieve a relatively low cost and/or non-invasive system which is still powerful in terms of monitoring for online detection of developing faults. The presented paper addresses rotor eccentricity faults and studies conventional monitoring techniques for induction motors. In order to reduce the unbalanced magnetic pull (UMP) in case of an eccentric rotor, the eccentricity-generated additional airgap flux waves should be reduced. The radial forces in an induction motor are calculated, and the characteristics of unbalanced magnetic pull are described.