Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrated Intrinsic and Dedicated Representations of Time: A Computational Study Involving Robotic Agents

The computational modeling of cognitive processes provides a systematic means to study hidden and particularly complex aspects of brain functionality. Given our rather limited understanding of how the brain deals with the notion of time, the implementation of computational models addressing duration processing can be particularly informative for studying possible time representations in our brain. In the present work we adopt a connectionist modeling approach to study how time experiencing and time processing may be encoded in a simple neural network trained to accomplish time-based robotic tasks. A particularly interesting characteristic of the present study is the implementation of a single computational model to accomplish not only one but three different behavioral tasks that assume diverse manipulation of time intervals. This setup enables a multifaceted exploration of duration-processing mechanisms, revealing a rather plausible hypothesis of how our brain deals with time. The model is implemented through an evolutionary design procedure, making a very limited set of a priori assumptions regarding its internal structure and machinery. Artificial evolution facilitates the unconstrained self-organization of time representation and processing mechanisms in the brain of simulated robotic agents. Careful examination of the artificial brains has shown that the implemented mechanisms incorporate characteristics from both the ‘intrinsic’ time representation scheme and the ‘dedicated’ time representation scheme. Even though these two schemes are widely considered as contradictory, the present study shows that it is possible to effectively integrate them in the same cognitive system. This provides a new view on the possible representation of time in the brain, and paves the way for new and more comprehensive theories to address interval timing.
Measles vaccination and inflammatory bowel disease: a national British cohort study

OBJECTIVE:Measles vaccination has been suggested as a risk for inflammatory bowel disease. Atypical age of measles infection has also been associated with Crohn's disease. This study was designed to examine the relationship of measles vaccination and age of measles vaccination with later inflammatory bowel disease.METHODS:A prospective population-based national birth cohort was used, of those born in 1 wk in April 1970 in Great Britain. The data are from 7616 responding members of the 1970 British Cohort Study with complete vaccination data, who were traced at age 26 yr. A diagnosis of Crohn's disease, ulcerative colitis, and diabetes mellitus (a control disease) was obtained by survey at age 26 yr, and confirmed by physicians. Vaccination data were from survey at age 5 yr. Measles and mumps infection data were obtained from the survey at age 10 yr. Adjustment was made for sex, household crowding in childhood, and father's social class at birth.RESULTS:No statistically significant association was found between measles vaccination status at 5 yr and Crohn's disease (adjusted odds ratio [OR] 0.67, 95% confidence interval [CI] 0.27–1.63), ulcerative colitis (adjusted OR 0.57, 95% CI 0.20–1.61), or diabetes (adjusted OR 0.75, 95% CI 0.33–1.74). There was a statistically significant trend (p= 0.040) with increasing age of measles vaccination for risk of Crohn's disease, although this was based on very few cases vaccinated after age 2 yr.CONCLUSIONS:In this cohort, monovalent measles vaccination status is not associated with inflammatory bowel disease by age 26 yr. Older age at measles vaccination needs to be examined in other studies to confirm whether it is a genuine risk for Crohn's disease.
Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA–Wild-Type Triple-Negative Breast Cancer

Patients with breast cancer brain metastases have extremely limited survival and no approved systemic therapeutics. Triple-negative breast cancer (TNBC) commonly metastasizes to the brain and predicts poor prognosis. TNBC frequently harbors BRCA mutations translating to platinum sensitivity potentially augmented by additional suppression of DNA repair mechanisms through PARP inhibition. We evaluated brain penetrance and efficacy of carboplatin ± the PARP inhibitor ABT888, and investigated gene-expression changes in murine intracranial TNBC models stratified by BRCA and molecular subtype status. Athymic mice were inoculated intracerebrally with BRCA-mutant: SUM149 (basal), MDA-MB-436 (claudin-low); or BRCA–wild-type (wt): MDA-MB-468 (basal), MDA-MB-231BR (claudin-low). TNBC cells were treated with PBS control [intraperitoneal (IP), weekly], carboplatin (50 mg/kg/wk, IP), ABT888 (25 mg/kg/d, oral gavage), or their combination. DNA damage (γ-H2AX), apoptosis (cleaved caspase-3, cC3), and gene expression were measured in intracranial tumors. Carboplatin ± ABT888 significantly improved survival in BRCA-mutant intracranial models compared with control, but did not improve survival in BRCA-wt intracranial models. Carboplatin + ABT888 revealed a modest survival advantage versus carboplatin in BRCA-mutant models. ABT888 yielded a marginal survival benefit in the MDA-MB-436, but not in the SUM149 model. BRCA-mutant SUM149 expression of γ-H2AX and cC3 proteins was elevated in all treatment groups compared with control, whereas BRCA-wt MDA-MB-468 cC3 expression did not increase with treatment. Carboplatin treatment induced common gene-expression changes in BRCA-mutant models. Carboplatin ± ABT888 penetrates the brain and improves survival in BRCA-mutant intracranial TNBC models with corresponding DNA damage and gene-expression changes. Combination therapy represents a potential promising treatment strategy for patients with TNBC brain metastases warranting further clinical investigation. Mol Cancer Ther; 14(4); 920–30. ©2015 AACR.
“From the Koran and Family Guy”: Expressions of Identity in English Learners’ Digital Podcasts

Framed in theories of social semiotics, this teacher research describes the implementation of a five-month unit on student identity in an eighth-grade reading/writing class for English learners. After learning about principles for multimodal design, students made their own digital podcasts in response to unit questions such as “Who am I? ” and “Where do I come from? ” The authors analyzed six students’ podcasts using a multimodal transcription chart, comparing these podcasts to students’ assignments throughout the unit and to student interviews about the podcasts. The authors’ analysis suggests that the podcasts promoted language development and enabled the students to simultaneously use multiple cultural and communicative resources in synergistic ways to express hybrid identities.
A cost model based on software maintainability

In this paper we present a maintainability based model for estimating the costs of developing source code in its evolution phase. Our model adopts the concept of entropy in thermodynamics, which is used to measure the disorder of a system. In our model, we use maintainability for measuring disorder (i.e. entropy) of the source code of a software system. We evaluated our model on three proprietary and two open source real world software systems implemented in Java, and found that the maintainability of these evolving software is decreasing over time. Furthermore, maintainability and development costs are in exponential relationship with each other. We also found that our model is able to predict future development costs with high accuracy in these systems.
Evaluating the Case for the Low-Level Approach to Agentive Awareness

Agentive awareness is the awareness one has of oneself as acting, or as performing a particular action. Theorists distinguish between high-level (e.g., Wegner 2002 ), low-level (e.g., Frith 2007), and integrative approaches (e.g., Pacherie 2008) to explaining this brand of subjective awareness. In this paper, I evaluate the commitment of both low-level and integrative approaches to the claim that the representations involved in sensorimotor control, specifically as described by the comparator model (e.g., Frith 1992), contribute in some significant way to agentive awareness. I examine the main empirical data offered in support of this claim and argue that it does not succeed in establishing a role for sensorimotor states in generating agentive awareness. This helps clear the way for high-level approaches to explaining this phenomenon.
Endogenous social capital and self-rated health: Results from Canada’s General Social Survey

Abstract In this study we analyze data from Statistics Canada’s General Social Survey, a cross-sectional and nationally representative survey of Canada’s population, to assess the impact of three dimensions of social capital on self-rated health. We measure these dimensions, which consist of social networks and social support, civic participation and social participation, with a comprehensive set of 5 indicators. To avoid reverse causality due to the cross-sectional nature of the data, we employ an instrumental variable simultaneous equations bivariate probit regression model. Our findings indicate that all of the tested dimensions of social capital have a positive and significant impact on self-rated health. These findings suggest that social capital plays an important role in enhancing the health of Canada’s population. Endogeneity was detected in all of our estimations. Consequently, this study also has important methodological implications in that we demonstrate that relying solely on naive estimations leads to biased results.
Planning as Strategy in Nonprofit Organizations: An Exploratory Study

This exploratory study examines formal planning processes in two different nonprofit organizations, those serving the mentally retarded and those in the performing arts, in two distinct geographical areas. Significant differences existed in the major types of Planning pro cesses employed by these nonprofits that seemed to relate to the nature of their funding environments. Important internal and exter nal factors influenced whether these forty-four nonprofits adopted plans for such matters as the size of the organization's budget, the primary function of its board of directors, and interaction with other local nonprofit managers engaged in formal planning. Differences in the extent of planning behavior between the two geographical areas suggests that local structures that support professional manage rial practices influence the diffusion of such practices.
Effect of Bee Venom and Its Fractions on the Release of Pro-Inflammatory Cytokines in PMA-Differentiated U937 Cells Co-Stimulated with LPS

The venom of Apis mellifera (honey bee) has been reported to play a role in immunotherapy, but existing evidence to support its immuno-modulatory claims is insufficient. Four fractions from whole bee venom (BV) were separated using medium pressure liquid chromatography. Their ability to induce the production of cytokines TNFα, IL-1β and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed. The levels of the three cytokines produced by stimulation with the four fractions and crude BV without LPS were not significantly different from negative control values. However, co-stimulation of the cells with LPS and Fraction 4 (F-4) induced a 1.6-fold increase in TNF-α level (p < 0.05) compared to LPS alone. Likewise, LPS-induced IL-1β production was significantly synergised in the presence of F-1 (nine-fold), F-2 (six-fold), F-3 (four-fold) and F-4 (two-fold) fractions, but was only slightly enhanced with crude BV (1.5-fold) relative to LPS. Furthermore, the LPS-stimulated production of IL-6 was not significantly increased in cells co-treated with F-2 and F-3, but the organic fraction (F-4) showed an inhibitory effect (p < 0.05) on IL-6 production. The latter was elucidated by NMR spectroscopy and found to contain(Z)-9-eicosen-1-ol. The effects observed with the purified BV fractions were more marked than those obtained with the crude sample.
Cryptogenic colitis due to occult cytomegalovirus infection

Colitis secondary to cytomegalovirus infection is well recognised and usually straightforward to diagnose. Here two cases are reported in whom all initial investigations failed to demonstrate the presence of virus, with potential adverse consequences for its treatment. A case is made for empirical antiviral therapy despite negative investigations if clinical suspicion is high.
Developmental eye-tracking research in reading: Introduction to the special issue

Extending our understanding of the interplay between visual and cognitive processes during reading is essential to understand how reading develops and changes across the lifespan. Monitoring readers' eye movements provides a fine-grained online protocol of the reading process as it evolves over time, but until recently eye movements have rarely been collected for young developing and ageing people. Developmental eye-tracking constitutes an emerging and innovative field that addresses various theoretical questions related to changes in the process of reading across the lifespan and the mechanisms that drive intra-individual trajectories and create inter-individual differences among readers. The aim of this editorial is to briefly summarise the current state of the field and to outline which questions are currently being investigated and presented in this Special Issue.
Postembryonic Establishment of Megabase-Scale Gene Silencing in Nucleolar Dominance

Nucleolar dominance is an epigenetic phenomenon in plant and animal genetic hybrids that describes the expression of 45S ribosomal RNA genes (rRNA genes) inherited from only one progenitor due to the silencing of the other progenitor's rRNA genes. rRNA genes are tandemly arrayed at nucleolus organizer regions (NORs) that span millions of basepairs, thus gene silencing in nucleolar dominance occurs on a scale second only to X-chromosome inactivation in female mammals. In Arabidopsis suecica, the allotetraploid hybrid of A. thaliana and A. arenosa, the A. thaliana –derived rRNA genes are subjected to nucleolar dominance and are silenced via repressive chromatin modifications. However, the developmental stage at which nucleolar dominance is established in A. suecica is currently unknown. We show that nucleolar dominance is not apparent in seedling cotyledons formed during embryogenesis but becomes progressively established during early postembryonic development in tissues derived from both the shoot and root apical meristems. The progressive silencing of A. thaliana rRNA genes correlates with the transition of A. thaliana NORs from a decondensed euchromatic state associated with histone H3 that is trimethylated on lysine 4 (H3K4me3) to a highly condensed heterochromatic state in which the NORs are associated with H3K9me2 and 5-methylcytosine-enriched chromocenters. In RNAi-lines in which the histone deacetylases HDA6 and HDT1 are knocked down, the developmentally regulated condensation and inactivation of A. thaliana NORs is disrupted. Collectively, these data demonstrate that HDA6 and HDT1 function in the postembryonic establishment of nucleolar dominance, a process which recurs in each generation.
Incremental Bayesian networks for structure prediction

We propose a class of graphical models appropriate for structure prediction problems where the model structure is a function of the output structure. Incremental Sigmoid Belief Networks (ISBNs) avoid the need to sum over the possible model structures by using directed arcs and incrementally specifying the model structure. Exact inference in such directed models is not tractable, but we derive two efficient approximations based on mean field methods, which prove effective in artificial experiments. We then demonstrate their effectiveness on a benchmark natural language parsing task, where they achieve state-of-the-art accuracy. Also, the model which is a closer approximation to an ISBN has better parsing accuracy, suggesting that ISBNs are an appropriate abstract model of structure prediction tasks.
Sense of "Calling": An Organizing Principle for the Lives and Values of Young Women in University

This qualitative study examined the experience of “life calling” in a sample of female Christian university students who felt a strong sense of calling. Participants were interviewed about the meaning and their experiences of life calling, with thematic analysis revealing the conception of life calling as an organizing and guiding force in these students’ lives, the nature of that calling, the process by which it emerged, and several salient attributes that these individuals had in common. The findings suggest that life calling is a distinct, identifiable phenomenon for some students and may be useful to consider in counselling with these clients.
Neuropsychiatric symptoms in Alzheimer's disease are related to functional connectivity alterations in the salience network

Neuropsychiatric syndromes are highly prevalent in Alzheimer's disease (AD), but their neurobiology is not completely understood. New methods in functional magnetic resonance imaging, such as intrinsic functional connectivity or “resting‐state” analysis, may help to clarify this issue. Using such approaches, alterations in the default‐mode and salience networks (SNs) have been described in Alzheimer's, although their relationship with specific symptoms remains unclear. We therefore carried out resting‐state functional connectivity analysis with 20 patients with mild to moderate AD, and correlated their scores on neuropsychiatric inventory syndromes (apathy, hyperactivity, affective syndrome, and psychosis) with maps of connectivity in the default mode network and SN. In addition, we compared network connectivity in these patients with that in 17 healthy elderly control subjects. All analyses were controlled for gray matter density and other potential confounds. Alzheimer's patients showed increased functional connectivity within the SN compared with controls (right anterior cingulate cortex and left medial frontal gyrus), along with reduced functional connectivity in the default‐mode network (bilateral precuneus). A correlation between increased connectivity in anterior cingulate cortex and right insula areas of the SN and hyperactivity syndrome (agitation, irritability, aberrant motor behavior, euphoria, and disinhibition) was found. These findings demonstrate an association between specific network changes in AD and particular neuropsychiatric symptom types. This underlines the potential clinical significance of resting state alterations in future diagnosis and therapy. Hum Brain Mapp 35:1237–1246, 2014. © 2013 Wiley Periodicals, Inc.
Minimal Suffix and Rotation of a Substring in Optimal Time

For a text given in advance, the substring minimal suffix queries ask to determine the lexicographically minimal non-empty suffix of a substring specified by the location of its occurrence in the text. We develop a data structure answering such queries optimally: in constant time after linear-time preprocessing. This improves upon the results of Babenko et al. (CPM 2014), whose trade-off solution is characterized by $\Theta(n\log n)$ product of these time complexities. Next, we extend our queries to support concatenations of $O(1)$ substrings, for which the construction and query time is preserved. We apply these generalized queries to compute lexicographically minimal and maximal rotations of a given substring in constant time after linear-time preprocessing. Our data structures mainly rely on properties of Lyndon words and Lyndon factorizations. We combine them with further algorithmic and combinatorial tools, such as fusion trees and the notion of order isomorphism of strings.
Comparative testing of empirical, data assimilation and physics-based ionospheric/thermospheric models

This paper compares and describes the ability of empirical, data assimilation and physics based ionospheric/thermospheric models to provide profiles of electron density below the peak of the F2 layer. A median empirical model, three data assimilation models and two different approaches to physics-based modelling are considered. A modified Taylor diagram is used to compare the second-order statistics of the foF2, hmF2 and h(0.8foF2) parameters simultaneously. The paper provides a preliminary study in understanding the effectiveness of using physics-based models as the background in Kalman filter data assimilation schemes. It is shown that the data assimilation models perform best followed by the median model and finally the physics based models.
The Emergence and Maintenance of Ethical Leadership in Organizations: A Question of Embeddedness?

The present paper gives a review of empirical research on ethical leadership and shows that still little is known known about the contextual antecedents of ethical leadership. To address this important issue, a conceptual framework is developed that analyzes the embeddedness of organizational ethical leadership. This framework identifies manifest and latent contextual factors on three different levels of analysis - society, industry, and organization - which can affect the development and maintenance of ethical leadership. In particular, propositions are offered about how (1) societal characteristics, notably the implementation and the spirit of human rights in a society and societal cultural values of responsibility, justice, humanity, and transparency; (2) industry characteristics such as environmental complexity, the content of the organizational mandate, and the interests of stakeholder networks; and (3) intra-organizational characteristics, including the organizational ethical infrastructure and the ethical leadership behavior of a leader's peer group, influence the development and maintenance of ethical leadership in organizations. This list of factors is not exhaustive, but illustrates how the three levels may impact ethical leadership. Implications for managerial practice and future research are discussed.
Analysis of an Adaptive Observer for Sensorless Control of Interior Permanent Magnet Synchronous Motors

This paper deals with a speed and position estimation method for the sensorless control of permanent magnet synchronous motors. The method is based on a speed-adaptive observer. The dynamics of the system are analyzed by linearizing both the motor model and the observer, and the observer gain is selected to give improved damping and noise suppression. At low speeds, the observer is augmented with a signal injection technique, providing stable operation down to zero speed. The experimental results, obtained using a 2.2-kW interior magnet motor, are in agreement with the results of the analysis.
Active contraction of microtubule networks

Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the large-scale behaviors of these systems. Here, we investigate the self-organization of stabilized microtubules in Xenopus oocyte extracts and find that they can form macroscopic networks that spontaneously contract. We propose that these contractions are driven by the clustering of microtubule minus ends by dynein. Based on this idea, we construct an active fluid theory of network contractions, which predicts a dependence of the timescale of contraction on initial network geometry, a development of density inhomogeneities during contraction, a constant final network density, and a strong influence of dynein inhibition on the rate of contraction, all in quantitative agreement with experiments. These results demonstrate that the motor-driven clustering of filament ends is a generic mechanism leading to contraction. DOI: http://dx.doi. org/10.7554/eLife.10837. 001