Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of PANC3 Score in Predicting Severity of Acute Pancreatitis

Introduction: Acute pancreatitis is inflammatory process of the pancreas associated with local and systemic complications. At present, there are lots of scores (such as Ransons, APACHE II, bedside index for severity in acute pancreatitis) that help us in predicting severity at the time of admission but these are time consuming or require complex calculation and are costly. Material and Methods: PANC3 Scoring System is one of the better systems because the three criteria used (hematocrit, body mass index, and pleural effusion) are simple, easy to assess, readily available, and economic. In this prospective study, 100 cases were evaluated to see the prospects of PANC3 scoring in predicting the severity of acute pancreatitis as decided by modified Marshals score. Results: The results showed that PANC3 score had a 96.43% specificity, 75% sensitivity, 80% positive predictive value, and 95.29% negative predictive value. Conclusion: Hence, the PANC3 score is a cost-effective, promising score that helps in predicting the severity of acute pancreatitis leading to prompt treatment and early referral to higher center.
Acoustic cues for emotions in vocal expression and music

Previous research shows that emotional expressions in speech and music use similar patterns of acoustic cues to communicate discrete emotions. The aim of the present study was to experimentally test if manipulation of the acoustic cues; F0, F0 variability, loudness, loudness variability and speech rate/tempo, affects the identification of discrete emotions in speech and music. Forty recordings of actors and musicians expressing anger, fear, happiness, sadness and tenderness were manipulated to either go with or against the acoustic patterns that previous studies suggest. Thirty-two participants listened to 120 recordings and judged which emotion they thought the actress or musician tried to communicate. Results showed an overall effect of manipulation in the expected direction, but the manipulation affected some emotions (anger, happiness and sadness) but not others (fear and tenderness). A non-significant interaction effect between manipulation and mode indicated that the manipulation had a similar effect on the stimulus for both speech and music.
Improving nitrogen use efficiency of dairy cows in relation to urea in milk - a review.

Dietary protein intake is the most important factor determining milk production, milk composition, milk nitrogen efficiency, urinary nitrogen losses, urea content in milk and consequently, ammonia emissions from dairy cow manure. According to the nutrition requirements two main protein sources are available for cows: rumen degradable protein, provided to the animal through ruminally synthesized microbial protein, and rumen undegradable protein that escapes ruminal degradation (but is digested and absorbed in the small intestine). The presence of urea in the milk of cows is caused by metabolic changes in the gastrointestinal tract, resulting in the excess of microbially undigested ammonia in the body. Rumen degradable feed proteins are degraded by rumen microorganisms via amino acids into ammonia and branched chain fatty acids. The bacterial population uses ammonia in order to grow. The extent, to which ammonia is used to synthesize microbial protein, is largely dependent upon the availability of energy generated by the fermentation of carbohydrates. On average, 20 grams of bacterial protein are synthesized per 100 grams of organic matter fermented in the rumen. Bacterial protein synthesis may range from less than 400 g/day to about 1500 g/day, depending primarily on the digestibility of the diet. A highly toxic chemical compound generated during those processes, i.e. ammonia, is detoxified in the liver and converted to urea. The main reason for elevated levels of urea in milk is connected with excess protein contents in feed rations, and energy and protein imbalance. The increase in the percentage of total protein from 13% to 18% DM per ration is accompanied by an increase in the urea level by about 80 mg to over 150 mg in 1 liter of milk. Additional factors affecting the level of urea in milk include the following: frequency of feed administration, number of milkings and length of the interval between milkings, cow’s body weight, water intake volume, the level of Na and K ration supplementation, as well as rumen pH. Recent research indicated that an addition of natural plant-origin biologically active compounds, such as tannins, saponins and essential oils, reduce ammonia production and finally urea content in milk. Information on the concentrations of milk urea and nitrogen in dairy cows allows to assess energy balance and protein rations supplied, which in turn can help to reduce both feed costs and nitrogen emission (N) to the environment.
Non-dominant sorting Firefly algorithm for pricing American option

An option, a type of a financial derivative, is a contract that creates an opportunity for a market player to avoid risks involved in investing, especially in equities. An investor desires to know the accurate value of an option before entering into a contract to buy/sell the underlying asset (stock). There are various techniques that try to simulate real market conditions in order to price or evaluate an option. However, most of them achieved limited success due to high uncertainty in price behavior of the underlying asset. In this study, we propose a new variant of multi-objective Firefly algorithm to compute the accurate worth of an American option contract and compare the results with the popular option pricing models: Binomial Lattice and Monte-Carlo using the real market data.
Regional Brain Stem Atrophy in Idiopathic Parkinson's Disease Detected by Anatomical MRI

Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder characterized by the dysfunction of dopaminergic dependent cortico-basal ganglia loops and diagnosed on the basis of motor symptoms (tremors and/or rigidity and bradykinesia). Post-mortem studies tend to show that the destruction of dopaminergic neurons in the substantia nigra constitutes an intermediate step in a broader neurodegenerative process rather than a unique feature of Parkinson's disease, as a consistent pattern of progression would exist, originating from the medulla oblongata/pontine tegmentum. To date, neuroimaging techniques have been unable to characterize the pre-symptomatic stages of PD. However, if such a regular neurodegenerative pattern were to exist, consistent damages would be found in the brain stem, even at early stages of the disease. We recruited 23 PD patients at Hoenn and Yahr stages I to II of the disease and 18 healthy controls (HC) matched for age. T1-weighted anatomical scans were acquired (MPRAGE, 1 mm3 resolution) and analyzed using an optimized VBM protocol to detect white and grey matter volume reduction without spatial a priori. When the HC group was compared to the PD group, a single cluster exhibited statistical difference (p<0.05 corrected for false detection rate, 4287 mm3) in the brain stem, between the pons and the medulla oblongata. The present study provides in-vivo evidence that brain stem damage may be the first identifiable stage of PD neuropathology, and that the identification of this consistent damage along with other factors could help with earlier diagnosis in the future. This damage could also explain some non-motor symptoms in PD that often precede diagnosis, such as autonomic dysfunction and sleep disorders.
Deliberative Innovation to Different Effect: Consensus Conferences in Denmark, France, and the United States

Democratic reformers are attracted by the role that advisory forums composed of lay citizens can play in public consultation on complex policy issues (such as participatory technology assessment). Using a comparative study of consensus conferences on the issue of genetically modified food in Denmark, France, and the United States, the authors show that the potential of such deliberative “mini-publics” is quite different in different sorts of political system. They attend to the mode of establishment, perceived legitimacy, policy impact, and influence on public debate of the forum in each case. In actively inclusive Denmark,mini-publics are deployed in integrative fashion; in exclusive France, in managerial fashion; and in the passively inclusive United States, in advocacy fashion. Proponents and practitioners of deliberative participatory reforms should take into account the constraints and opportunities revealed by this analysis and attend to the different roles that mini-publics might play in different political systems.
A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder

The norepinephrine transporter critically regulates both neurotransmission and homeostasis of norepinephrine in the nervous system. In this study, we report a previously uncharacterized and common A/T polymorphism at −3081 upstream of the transcription initiation site of the human norepinephrine transporter gene [solute carrier family 6, member 2 (SLC6A2)]. Using both homologous and heterologous promoter-reporter constructs, we found that the −3081(T) allele significantly decreases promoter function compared with the A allele. Interestingly, this T allele creates a new palindromic E2-box motif that interacts with Slug and Scratch, neural-expressed transcriptional repressors binding to the E2-box motif. We also found that both Slug and Scratch repress the SLC6A2 promoter activity only when it contains the T allele. Finally, we observed a significant association between the −3081(A/T) polymorphism and attention-deficit hyperactivity disorder (ADHD), suggesting that anomalous transcription factor-based repression of SLC6A2 may increase risk for the development of attention-deficit hyperactivity disorder and other neuropsychiatric diseases.
Restraining mycobacteria: Role of granulomas in mycobacterial infections

The generation of prolonged immunity to Mycobacterium tuberculosis requires not only an antigen‐specific IFN‐γ‐producing T cell response, including both CD4 and CD8 T cells, but also the generation of protective granulomatous lesions, whereby the close apposition of activated T cells and macrophages acts to contain bacterial growth. The importance of the granulomatous lesion in controlling this immune response and in limiting both tissue damage and bacterial dissemination has been considered a secondary event but, as the present review illustrates, is no less important in surviving mycobacterial infection than an antigen‐specific T‐cell response. The formation of a protective granuloma involves the orchestrated production of a host of chemokines and cytokines, the upregulation of their receptors along with upregulation of addressins, selectins and integrins to coordinate the recruitment, migration and retention of cells to and within the granuloma. In the present review, the principal components of the protective response are outlined and the role of granuloma formation and maintenance in mediating prolonged containment of mycobacteria within the lung is addressed.
A Role for HSP70 in Protecting against Indomethacin-induced Gastric Lesions*

A major clinical problem encountered with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, is gastrointestinal complications. Both NSAID-dependent cyclooxygenase inhibition and gastric mucosal apoptosis are involved in NSAID-produced gastric lesions, and this apoptosis is mediated by the endoplasmic reticulum stress response and resulting activation of Bax. Heat shock proteins (HSPs) have been suggested to protect gastric mucosa from NSAID-induced lesions; here we have tested this idea genetically. The severity of gastric lesions produced by indomethacin was worse in mice lacking heat shock factor 1 (HSF1), a transcription factor for hsp genes, than in control mice. Indomethacin administration up-regulated the expression of gastric mucosal HSP70. Indomethacin-induced gastric lesions were ameliorated in transgenic mice expressing HSP70. After indomethacin administration, fewer apoptotic cells were observed in the gastric mucosa of transgenic mice expressing HSP70 than in wild-type mice, whereas the gastric levels of prostaglandin E2 for the two were indistinguishable. This suggests that expression of HSP70 ameliorates indomethacin-induced gastric lesions by affecting mucosal apoptosis. Suppression of HSP70 expression in vitro stimulated indomethacin-induced apoptosis and activation of Bax but not the endoplasmic reticulum stress response. Geranylgeranylacetone induced HSP70 at gastric mucosa in an HSF1-dependent manner and suppressed the formation of indomethacin-induced gastric lesions in wild-type mice but not in HSF1-null mice. The results of this study provide direct genetic evidence that expression of HSP70 confers gastric protection against indomethacin-induced lesions by inhibiting the activation of Bax. The HSP inducing activity of geranylgeranylacetone seems to contribute to its gastroprotective activity against indomethacin.
Perceived Usefulness, Perceived Ease of Use, and User Acceptance of Information Technology

Valid measurement scales for predicting user acceptance of computers are in short supply. Most subjective measures used in practice are unvalidated, and their relationship to system usage is unknown. The present research develops and validates new scales for two specific variables, perceived usefulness and perceived ease of use, which are hypothesized to be fundamental determinants of user acceptance. Definitions of these two variables were used to develop scale items that were pretested for content validity and then tested for reliability and construct validity in two studies involving a total of 152 users and four application programs. The measures were refined and streamlined, resulting in two six-item scales with reliabilities of . 98 for usefulness and . 94 for ease of use. The scales exhibited hgih convergent, discriminant, and factorial validity. Perceived usefulness was significnatly correlated with both self-reported current usage r = . 63, Study 1) and self-predicted future usage r = . 85, Study 2). Perceived ease of use was also significantly correlated with current usage r = . 45, Study 1) and future usage r = . 59, Study 2). In both studies, usefulness had a signficnatly greater correaltion with usage behavior than did ease of use. Regression analyses suggest that perceived ease of use may actually be a causal antecdent to perceived usefulness, as opposed to a parallel, direct determinant of system usage. Implications are drawn for future research on user acceptance.
EXISTENCE AND UNIQUENESS FOR A SEMILINEAR ELLIPTIC PROBLEM ON LIPSCHITZ DOMAINS IN RIEMANNIAN MANIFOLDS

ABSTRACT For a general class of semilinear equations in a Lipschitz domain , where M is a smooth compact Riemannian manifold, we establish the existence and uniqueness of solutions to Dirichlet and Neumann boundary problems. The main contribution of this paper is that we consider ‘rough’ boundary data that are typically just functions. Results of this type for the linear equation are typically obtained using singular integral techniques.
Investigation of Mitochondrial Dysfunction by Sequential Microplate-Based Respiration Measurements from Intact and Permeabilized Neurons

Mitochondrial dysfunction is a component of many neurodegenerative conditions. Measurement of oxygen consumption from intact neurons enables evaluation of mitochondrial bioenergetics under conditions that are more physiologically realistic compared to isolated mitochondria. However, mechanistic analysis of mitochondrial function in cells is complicated by changing energy demands and lack of substrate control. Here we describe a technique for sequentially measuring respiration from intact and saponin-permeabilized cortical neurons on single microplates. This technique allows control of substrates to individual electron transport chain complexes following permeabilization, as well as side-by-side comparisons to intact cells. To illustrate the utility of the technique, we demonstrate that inhibition of respiration by the drug KB-R7943 in intact neurons is relieved by delivery of the complex II substrate succinate, but not by complex I substrates, via acute saponin permeabilization. In contrast, methyl succinate, a putative cell permeable complex II substrate, failed to rescue respiration in intact neurons and was a poor complex II substrate in permeabilized cells. Sequential measurements of intact and permeabilized cell respiration should be particularly useful for evaluating indirect mitochondrial toxicity due to drugs or cellular signaling events which cannot be readily studied using isolated mitochondria.
Physicians' Subjectivity in Evaluating Oxytocin Challenge Tests

Five physicians subspecializing in maternal-fetal medicine individually evaluated 50 oxytocin challenge tests (OCTs), of which 33 were originally read as positive. There was considerable disagreement among the study physicians (SPs) such that 2 SPs would agree, on the average, only 52% of the time on any one OCT. The SPs were also asked to evaluate fetal heart rate (FHR) reactivity patterns, if present. Again, there was great disagreement. When the majority (3 of 5 or more) of SPs agreed on the OCT result and/or reactivity, there was reasonable correlation with neonatal outcome, indicating the validity of the physiologic premise of the test. In particular, the presence or absence of FHR accelerations with fetal motion, regardless of the OCT reading, correlated extremely well with eventual neonatal outcome. This indicates that the most significant variable in antepartum FHR monitoring is the FHR acceleration pattern
The front lines of the “back door”: Navigating (dis)engagement, coercion, and pleasure in women’s anal sex experiences

Despite the frequent depiction of heterosexual anal sex in pornography, and growing indications that heterosexual couples engage in anal sex, almost no research has examined women’s subjective experiences with receptive anal sex with men. This study draws upon qualitative interviews with 20 American women (mean age = 34, SD = 13.35) from diverse ages and backgrounds to illuminate five themes in women’s narratives about receptive anal sex: (1) initial resistance followed by submission; (2) initial interest followed by withdrawal from subsequent anal sex experiences; (3) violence and coercion surrounding anal sex; (4) social norming (e.g. men’s male friends normalizing heterosexual anal sex; seeing anal sex as normative after watching pornography); and (5) pleasurable experiences with anal eroticism. Implications for the re-evaluation of consent, imagining a continuum of sexualized violence, heteronormative assumptions about access to and power over women, silences surrounding non-penetrative anal eroticism, and women’s (dis)engagement with anal sex are explored.
Effect of Non-surgical Periodontal Therapy on Serum and Salivary Concentrations of Visfatin in Patients with Chronic Periodontitis

Background and aims. Visfatin, mainly secreted by visceral adipose tissue, especially by macrophages, plays an important role in regulating the defense and immune functions, and functions as a growth factor, a cytokine, an enzyme and more importantly as a proinflammatory mediator. The aim of the present study was to evaluate the effect of non-surgical periodontal treatment on serum and salivary levels of visfatin in patients with generalized moderate-to-severe chronic periodontitis. Materials and methods. Eighteen patients with generalized moderate-to-severe chronic periodontitis were selected based on periodontal parameters of gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) and radiographic parameters. Serum and salivary samples were collected at baseline and one month following non-surgical periodontal therapy (scaling and root planing ([SRP]). Visfatin levels were measured using an ELISA kit. Data were analyzed by SPSS 15, using paired t-test and Pearson's correlation coefficient. Results. Mean salivary and serum levels of visfatin significantly decreased after non-surgical periodontal treatment (P<0.05). Changes in salivary visfatin levels were more prominent. Conclusion. According to the findings of this study it seems that there is a direct relationship between periodontal tissue inflammation and disease activity with salivary and serum visfatin levels.
Human T-cell lymphotropic virus type 1 infection and ocular manifestations in São Paulo, Brazil.

OBJECTIVES Although human T-cell lymphotropic virus type 1 (HTLV-1)-associated uveitis has been well recognized in Japan, related studies in Brazil are scarce. We performed a serologic survey for HTLV-1 infection among patients with uveitis and investigated the ocular findings in HTLV-1-asymptomatic carriers. METHODS One hundred ninety serum samples from patients with uveitis of determined (n = 137) and undetermined origins (n = 53) being examined at the Uveitis Service, University of São Paulo, São Paulo, Brazil, underwent testing using HTLV enzyme-linked immunosorbent assay and discriminatory Western blots. One hundred five asymptomatic blood donors and/or their relatives who were seropositive for HTLV-1 (carrier group) and 105 age- and sex-paired blood donors who were seronegative for HTLV-1 (control group) underwent ocular evaluation. For the statistical analysis, chi2 test was used. RESULTS Only 1 patient with uveitis was seropositive for HTLV- 1, and she belonged to the group with uveitis of undetermined origin. Results of tear films were evaluated in 52 carriers. The prevalence of a decreased tear break-up time was significantly higher in the carrier compared with the control group (P = .02). Two carriers had keratoconjunctivitis sicca. Three of the 105 carriers exhibited mild uveitis (cells in the vitreous, retinal and choroidal infiltrates, retinal vasculitis, and bilateral pars planitis). Retinal pigmentary changes were found in both groups (no statistical difference). CONCLUSIONS Early tear abnormalities may be present in asymptomatic carriers, and mild uveitis may be found among them. The relatively low seroprevalence of HTLV-1 in the Brazilian population made it difficult to establish the real importance of HTLV-1-associated uveitis among our patients with uveitis.