Miracle-dz/UniFAR-FTUs huggingface dataset:
Attitudinal Responses to Mixed Evidence: The Role of Attitude Extremity and Political Ideology in Effecting Change versus Resistance

ATTITUDINAL RESPONSES TO MIXED EVIDENCE: THE ROLE OF ATTITUDE EXTREMITY AND POLITICAL IDEOLOGY IN EFFECTING CHANGE VERSUS RESISTANCE By Jessica M. Barber, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Major Director: Natalie J. Shook, Assistant Professor Department of Psychology Four studies investigated the effects of attitude extremity and political ideology on the degree and direction of changes in issue attitudes following the presentation of mixed evidence. Based upon previous work, it was predicted that those holding relatively more extreme attitudes would resist changing those views when presented with a mixture of supporting and opposing statements and would potentially adopt more extreme evaluative positions – a phenomenon known as attitude polarization (Lord, Ross, & Lepper, 1979). Evaluative entrenchment or intensification was also expected among more politically conservative participants, based upon prior work describing cognitive rigidity and resistance to change as more characteristic of the political right than left (e.g., Jost, Glaser, Kruglanski, & Sulloway, 2003). An interaction of attitude extremity and political ideology was also hypothesized, such that liberal individuals with moderate attitudes were expected to demonstrate the least propensity to polarize. Participants’ attitudes regarding abortion rights (Study 1), gun control (Study 2), tax increases (Study 3), and environmental preservation (Study 4) were assessed before and after reading statements that both opposed and supported the issue. Political ideology was also assessed, along with several individual difference factors. Across all four studies, attitude extremity significantly predicted evaluative change, although the pattern of that effect varied. Political ideology did not emerge consistently as a predictor of attitude change; however, significant interactive effects of extremity and ideology were found. In addition, several individual difference factors (i.e., gender, need for cognition, issue importance) were found to moderate the effects of the primary predictors on attitude change, and some divergent result patterns were found when comparing data from a college and non-college sample in Study 4. Taken together, these studies provide evidence that attitude extremity and political ideology influence the degree and direction of evaluative change following the presentation of mixed evidence. In addition, they identify other factors at work in effecting change versus resistance, thereby highlighting the multi-faceted and complex nature of persuasion in a political context.
Overall survival, renal survival and relapse in patients with microscopic polyangiitis: a systematic review of current evidence.

OBJECTIVE There are limited data on the long-term prognosis of microscopic polyangiitis (MPA). A systematic review was performed to estimate the survival, renal survival and relapse rates in patients with MPA. METHODS Articles included in MEDLINE and EMBASE databases were reviewed. Randomized or non-randomized trials, cohort, case-control and cases-series studies of patients with MPA diagnosed according to Chapel Hill Consensus Conference definitions, a high rate of biopsy-confirmed diagnosis, follow-up >1 year and follow-up losses <10%. Two independent authors using a predefined questionnaire for evaluating the quality and risk of bias for each study extracted data. RESULTS Eighteen studies for MPA prognosis (n = 940) and six for MPA outcomes after transplantation (n = 65) were included. Survival rates were 77-100% at 1 year, 46-80% at 5 years and 60-80% at 10 years. Higher mortality density occurred within the first months after diagnosis. Vasculitis was the cause of death in 32-50% of patients. Relapses were detected in 19-39% of cases (median time to relapse 15-43 months). Renal graft survival was 85-94% at 1 year and 51-87% at 5 years. Age, renal involvement and immunosuppressive treatment were related to mortality. Lower relapse rate was achieved with 12 vs 6 CYC pulses. CONCLUSION Evidence regarding MPA prognosis is weak. MPA mortality is mainly concentrated in the first months after diagnosis. Fewer than 50% of deaths are related to MPA activity. MPA long-term prognosis is less severe, although relapses are frequent. End-stage renal failure is a frequent complication of MPA, and renal transplantation could be an effective therapy in these patients. Early diagnosis, early initiation of a tailored therapy according to risk factors and a longer follow-up of the patients are needed.
Formation of glycosidases in batch and continuous culture of Bacteroides fragilis

Nine strains of bacteroides fragilis were cultivated in stirred fermentors and tested for their ability to produce glycosidases. B. fragilis subsp. vulgatus B70 was used for optimizing the production of glycosidases. The highest bacterial yield was obtained in proteose peptone-yeast extract medium. The optimum pH for maximal bacterial yield was 7.0, and the optimum temperature for growth was 37 degrees C. The formation of glycosidases was optimal between pH 6.5 and 7.5, and the optimum temperature for synthesis of glycosidases was between 33 and 37 degrees C. Culture under controlled conditions in fermentors gave more reproducible production of glycosidases than static cultures in bottles. The strain was also grown in continuous culture at a dilution rate of 0.1 liter/h at pH 7.0 and 37 degrees C with a yield of 2.0 mg of dry weight per ml in the complex medium. The formation of glycosidases remained constant during the entire continuous process.
Dual PI 3 K / mTOR Inhibitors Induce Rapid Overactivationof theMEK / ERKPathway inHuman Pancreatic Cancer Cells through Suppression of mTORC 2

The PI3K/AKT/mTOR pathway, which is aberrantly stimulated in many cancer cells, has emerged as a target for therapy. However, mTORC1/S6K also mediates negative feedback loops that attenuate upstream signaling. Suppression of these feedback loops opposes the growth-suppressive effects of mTOR inhibitors and leads to drug resistance. Here, we demonstrate that treatment of PANC-1orMiaPaCa-2 pancreatic ductal adenocarcinoma (PDAC) cells with the dual PI3K/mTOR kinase inhibitor (PI3K/ TOR-KI) BEZ235 blocked mTORC1/S6K activation (scored by S6 phosphorylation at Ser), mTORC1/4E-BP1 (assayed by 4E-BP1 phosphorylation at Thr), and mTORC2-mediated AKT phosphorylation at Ser, in a concentration-dependent manner. Strikingly, BEZ235 markedly enhanced the MEK/ERK pathway in a dose-dependent manner. Maximal ERK overactivation coincided with complete inhibition of phosphorylation of AKT and 4E-BP1. ERK overactivation was induced by other PI3K/ TOR-KIs, including PKI-587 and GDC-0980. The MEK inhibitors U126 or PD0325901 prevented ERK overactivation induced by PI3K/TOR-KIs. The combination of BEZ235 and PD0325901 caused a more pronounced inhibition of cell growth than that produced by each inhibitor individually. Mechanistic studies assessing PI3K activity in single PDAC cells indicate that PI3K/ TOR-KIs act through a PI3K-independent pathway. Doses of PI3K/TOR-KIs that enhanced MEK/ERK activation coincided with those that inhibited mTORC2-mediated AKT phosphorylation on Ser, suggesting a role of mTORC2. Knockdown of RICTOR via transfection of siRNA markedly attenuated the enhancing effect of BEZ235onERKphosphorylation.Wepropose that dual PI3K/mTOR inhibitors suppress a novel negative feedback loop mediated by mTORC2, thereby leading to enhanced MEK/ERK pathway activity in pancreatic cancer cells. Mol Cancer Ther; 14(4); 1–10. 2015 AACR.
Disordered eating and the transition to college: a prospective study.

OBJECTIVE A longitudinal study was conducted to examine whether the transition to college changed eating disorder symptoms and related attitudes. METHOD Participants were 342 women who completed an in-depth survey in the spring of their senior year of high school and again during their first year of college. We assessed changes in body self-perception, eating-related attitudes, and disordered eating classification (nondieter, dieter, problem dieter, subclinical eating disordered, or eating disordered on the basis of criteria for bulimia nervosa in the 4th ed. of the Diagnostic and Statistical Manual of Mental Disorders). RESULTS Although participants viewed themselves as significantly heavier in their first year of college, dieting frequency and disordered eating classification in college did not differ from high school assessment. DISCUSSION Evidence from this study indicates that disordered eating symptoms and attitudes are established before college. However, our findings also reveal that poor self-image, dieting behaviors, and eating disorder symptoms are common among many young women, both before and during college.
Asymmetries of Dark and Bright Negative Afterimages Are Paralleled by Subcortical ON and OFF Poststimulus Responses

Humans are more sensitive to luminance decrements than increments, as evidenced by lower thresholds and shorter latencies for dark stimuli. This asymmetry is consistent with results of neurophysiological recordings in dorsal lateral geniculate nucleus (dLGN) and primary visual cortex (V1) of cat and monkey. Specifically, V1 population responses demonstrate that darks elicit higher levels of activation than brights, and the latency of OFF responses in dLGN and V1 is shorter than that of ON responses. The removal of a dark or bright disc often generates the perception of a negative afterimage, and here we ask whether there also exist asymmetries for negative afterimages elicited by dark and bright discs. If so, do the poststimulus responses of subcortical ON and OFF cells parallel such afterimage asymmetries? To test these hypotheses, we performed psychophysical experiments in humans and single-cell/S-potential recordings in cat dLGN. Psychophysically, we found that bright afterimages elicited by luminance decrements are stronger and last longer than dark afterimages elicited by luminance increments of equal sizes. Neurophysiologically, we found that ON cells responded to the removal of a dark disc with higher firing rates that were maintained for longer than OFF cells to the removal of a bright disc. The ON and OFF cell asymmetry was most pronounced at long stimulus durations in the dLGN. We conclude that subcortical response strength differences between ON and OFF channels parallel the asymmetries between bright and dark negative afterimages, further supporting a subcortical origin of bright and dark afterimage perception. SIGNIFICANCE STATEMENT Afterimages are physiological aftereffects following stimulation of the eye, the study of which helps us to understand how our visual brain generates visual perception in the absence of physical stimuli. We report, for the first time to our knowledge, asymmetries between bright and dark negative afterimages elicited by luminance decrements and increments, respectively. Bright afterimages are stronger and last longer than dark afterimages. Subcortical neuronal recordings of poststimulus responses of ON and OFF cells reveal similar asymmetries with respect to response strength and duration. Our results suggest that subcortical differences between ON and OFF channels help explain intensity and duration asymmetries between bright and dark afterimages, supporting the notion of a subcortical origin of bright and dark afterimages.
Detecting implausible social network effects in acne, height, and headaches: longitudinal analysis

Objective To investigate whether “network effects” can be detected for health outcomes that are unlikely to be subject to network phenomena. Design Statistical analysis common in network studies, such as logistic regression analysis, controlled for own and friend’s lagged health status. Analyses controlled for environmental confounders. Setting Subsamples of the National Longitudinal Study of Adolescent Health (Add Health). Participants 4300 to 5400 male and female adolescents who nominated a friend in the dataset and who were both longitudinally surveyed. Measurements Health outcomes, including headache severity, acne severity, and height self reported by respondents in 1994-5, 1995-6, and 2000-1. Results Significant network effects were observed in the acquisition of acne, headaches, and height. A friend’s acne problems increased an individual’s odds of acne problems (odds ratio 1.62, 95% confidence interval 0.91 to 2.89). The likelihood that an individual had headaches also increased with the presence of a friend with headaches (1.47, 0.93 to 2.33); and an individual’s height increased by 20% of his or her friend’s height (0.18, 0.15 to 0.26). Each of these results was estimated by using standard methods found in several publications. After adjustment for environmental confounders, however, the results become uniformly smaller and insignificant. Conclusions Researchers should be cautious in attributing correlations in health outcomes of close friends to social network effects, especially when environmental confounders are not adequately controlled for in the analysis.
Methylation pattern of different regions of the MLH1 promoter and silencing of gene expression in hereditary and sporadic colorectal cancer

Nonrandom, widespread promoter methylation of tumor suppressor genes is a common mechanism of gene inactivation during tumorigenesis. We examined the methylation status of two distinct regions of the MLH1 promoter (proximal and distal to the transcription start site) and the MLH1 gene expression by methylation‐specific PCR and immunohistochemistry. A total of 72 colorectal tumors, both with (n = 51, 22 affected by hereditary nonpolyposis colorectal cancer, HNPCC, defined according to the international clinical criteria and 29 sporadic cases) and without microsatellite instability (MSI) (n = 21) were studied. Methylation was present in at least one of the two promoter regions in 86% of the sporadic MSI cases, in 33% of the cases lacking MSI, and in 23% of the HNPCC tumors. In the HNPCC cases with a known MLH1 mutation (n = 10) none of the two promoter regions was methylated. Hypermethylation in both MLH1 promoter regions was seen in 45% of the MSI sporadic cases vs. 5% of the MSI‐negative cases and 0% of the HNPCC cases. The overall concordance between the two promoter regions regarding methylation status was good (P = 0.009), but no significant correlation between methylation and suppression of the MLH1 immunohistochemical expression was found. Our data confirm that mutation and hypermethylation are mutually exclusive mechanisms in inducing mismatch repair deficiency and support the hypothesis of methylation as a process evenly distributed along the different regions of the promoter. © 2001 Wiley‐Liss, Inc.
Peer Choice in CEO Compensation

Current research shows that firms are more likely to benchmark against peers that pay their Chief Executive Officers (CEOs) higher compensation, reflecting self-serving behavior. We propose an alternative explanation: the choice of highly paid peers represents a reward for unobserved CEO talent. We test this hypothesis by decomposing the effect of peer selection into talent and self-serving components. Consistent with our prediction, we find that the association between a firm’s selection of highly paid peers and CEO pay mostly represents compensation for CEO talent.
Training Manager Rendering Task Generator Headless Browser Cluster Browser Instance Browser Instance Link Spider / Test Cases Template Generator Host Whitelist Generator Template

Content security policy (CSP)—which has been standardized by W3C and adopted by all major commercial browsers—is one of the most promising approaches for defending against cross-site scripting (XSS) attacks. Although client-side adoption of CSP is successful, server-side adoption is far behind the client side: according to a large-scale survey, less than 0.002% of Alexa Top 1M websites enabled CSP. To facilitate the adoption of CSP, we propose CSPAutoGen to enable CSP in real-time, without server modifications, and being compatible with real-world websites. Specifically, CSPAutoGen trains so-called templates for each domain, generates CSPs based on the templates, rewrites incoming webpages on the fly to apply those generated CSPs, and then serves those rewritten webpages to client browsers. CSPAutoGen is designed to automatically enforce the most secure and strict version of CSP without enabling “unsafe-inline” and “unsafe-eval”, i.e., CSPAutoGen can handle all the inline and dynamic scripts. We have implemented a prototype of CSPAutoGen, and our evaluation shows that CSPAutoGen can correctly render all the Alexa Top 50 websites. Moreover, we conduct extensive case studies on five popular websites, indicating that CSPAutoGen can preserve the behind-the-login functionalities, such as sending emails and posting comments. Our security analysis shows that CSPAutoGen is able to defend against all the tested real-world XSS attacks.
Association between rhythmic masticatory muscle activity during sleep and masticatory myofascial pain: a polysomnographic study.

AIMS To test for an association between rhythmic masticatory muscle activity during sleep, as assessed according to polysomnographic criteria for sleep bruxism (RMMA-SB), and myofascial pain (MFP), as well as the chance of occurrence of MFP in patients with RMMA-SB. METHODS Thirty MFP patients (diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorders) and 30 age- and gender-matched asymptomatic controls underwent a polysomnographic examination. Also, any self-reporting of daytime clenching (DC) was registered in 58 of these subjects. RESULTS Most MFP patients reported mild or moderate pain (46.67% and 43.33%, respectively), and only 3 (10%) reported severe pain. Pain duration ranged from 2 to 120 months (mean 34.67 +/- 36.96 months). Significant associations were observed between RMMA-SB and MFP as well as between DC and MFP. CONCLUSIONS (1) RMMA-SB is significantly associated with MFP; (2) although RMMA-SB represents a risk factor for MFP, this risk is low; and (3) DC probably constitutes a stronger risk factor for MFP than RMMA-SB.
Particle migration in pressure-driven flow of a Brownian suspension

Shear-induced migration of 2 $\mu$m diameter spherical colloidal particles flowing through rectangular channels (50 $\mu$m $\times$ 500 $\mu$m cross-section) is studied by confocal microscopy. The confocal microscope allows imaging of the flowing particles far from the walls of the channel, at particle velocities up to 8000 $\mu$m s$^{-1}$. The particle volume fraction is varied from $\phi = 0.05$ to 0.34, and the flow rate is also varied, which results in a bulk Péclet number (${\hbox{\it Pe}}_{\rm B}$) which varies by two orders of magnitude. Concentration profiles are measured across the narrow dimension of the channel; particles at the larger volume fractions migrate toward the centreline, with the migration progressively stronger as ${\hbox{\it Pe}}_{\rm B}$ increases. The flow has been analysed using an existing mixture flow model under the assumption of fully developed flow and a proposed constitutive law which describes the suspension normal stresses as a function of both $\phi$ and the local Péclet number, ${\hbox{\it Pe}}$, the latter being defined as a variable quantity through the local shear rate. Shear thinning and shear thickening are not included. Comparisons made with the experimental data indicate that the dependence of the extent of migration upon ${\hbox{\it Pe}}_{\rm B}$ is captured well but discrepancies arise, at least in part because the assumption of full development is not valid for these experiments.
Disentangling the prefrontal network for rule selection by means of a non‐verbal variant of the Wisconsin Card Sorting Test

This study disentangles the prefrontal network underlying executive functions involved in the Wisconsin Card Sorting Test (WCST). During the WCST, subjects have to perform two key processes: first, they have to derive the correct sorting rule for each trial by trial‐and‐error, and, second, they have to detect when this sorting rule is changed by the investigator. Both cognitive processes constitute key components of the executive system, which is subserved by the prefrontal cortex. For the current fMRI experiment, we developed a non‐verbal variant of the WCST. Subjects were instructed either to respond according to a given sorting rule or to detect the correct sorting rule, like in the original version of the WCST. Data were obtained from 14 healthy male volunteers and analysed using SPM and a random effects model. All conditions activated a fronto‐parietal network, which was generally more active when subjects had to search for the correct sorting rule than when the rule was announced beforehand. Significant differences between these two conditions were seen in the dorsolateral prefrontal cortex (PFC) and the parietal lobe. In addition, the data provided new evidence for the assumption of differentiated roles of the left and right prefrontal cortex. Although the right PFC showed a general involvement in response selection and the execution of goal directed responses, based on given rules, the left PFC was only activated when inductive reasoning and feedback integration was required. Hum Brain Mapp 2009. © 2008 Wiley‐Liss, Inc.
Early Auditory Evoked Potential Is Modulated by Selective Attention and Related to Individual Differences in Visual Working Memory Capacity

A growing body of research suggests that the predictive power of working memory (WM) capacity for measures of intellectual aptitude is due to the ability to control attention and select relevant information. Crucially, attentional mechanisms implicated in controlling access to WM are assumed to be domain-general, yet reports of enhanced attentional abilities in individuals with larger WM capacities are primarily within the visual domain. Here, we directly test the link between WM capacity and early attentional gating across sensory domains, hypothesizing that measures of visual WM capacity should predict an individual's capacity to allocate auditory selective attention. To address this question, auditory ERPs were recorded in a linguistic dichotic listening task, and individual differences in ERP modulations by attention were correlated with estimates of WM capacity obtained in a separate visual change detection task. Auditory selective attention enhanced ERP amplitudes at an early latency (ca. 70–90 msec), with larger P1 components elicited by linguistic probes embedded in an attended narrative. Moreover, this effect was associated with greater individual estimates of visual WM capacity. These findings support the view that domain-general attentional control mechanisms underlie the wide variation of WM capacity across individuals.
Atrial Arrhythmias in Obstructive Sleep Apnea: Underlying Mechanisms and Implications in the Clinical Setting

Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive interruption of ventilation during sleep caused by recurrent upper airway collapse, which leads to intermittent hypoxia. The disorder is commonly undiagnosed despite its relationship with substantial cardiovascular morbidity and mortality. Moreover, the effects of the disorder appear to be particularly dangerous in young subjects. In the last decade, substantial clinical evidence has identified OSA as independent risk factor for both bradyarrhythmias and tachyarrhythmias. To date the mechanisms leading to such arrhythmias have not been completely understood. However, recent data from animal models and new molecular analyses have increased our knowledge of the field, which might lead to future improvement in current therapeutic strategies mainly based on continuous positive airway pressure. This paper aims at providing readers a brief and specific revision of current knowledge about the mechanisms underlying atrial arrhythmias in OSA and their clinical and therapeutic implications.