Miracle-dz/UniFAR-FTUs huggingface dataset:
Cost-based Deployment Planning for Components in Smart Item Environments

Middleware for smart items can facilitate the coordinated execution of distributed components for early data processing. These components can be deployed to different nodes in the middleware or even on the smart item itself. While such flexibility is desirable to fulfil various information requirements from backend applications, it poses the problem of finding good distributions for given components and component compositions. In this paper, we present an approach for deployment planning of components based on their expected resource consumption under a certain load. Using an example scenario we analyse the influencing factors on placement decisions. These are integrated into an evaluation schema. The concept is proven by an implementation, which is used to find suitable distributions for the example scenario with varying loads. We present the results and discuss the effect of different load settings.
Learning-Dependent Increases in Sleep Spindle Density

Declarative memory consolidation is enhanced by sleep. In the investigation of underlying mechanisms, mainly rapid eye movement (REM) sleep and slow-wave sleep have been considered. More recently, sleep stage 2 with sleep spindles as a most prominent feature has received increasing attention. Specifically, in rats hippocampal ripples were found to occur in temporal proximity to cortical sleep spindles, indicating an information transfer between the hippocampus and neocortex, which is supposed to underlie the consolidation of declarative memories during sleep. This study in humans looks at the changes in EEG activity during nocturnal sleep after extensive training on a declarative learning task, as compared with a nonlearning control task of equal visual stimulation and subjectively rated cognitive strain. Time spent in each sleep stage, spindle density, and EEG power spectra for 28 electrode locations were determined. During sleep after training, the density of sleep spindles was significantly higher after the learning task as compared with the nonlearning control task. This effect was largest during the first 90 min of sleep (p < 0.01). Additionally, spindle density was correlated to recall performance both before and after sleep (r = 0.56; p < 0.05). Power spectra and time spent in sleep stages did not differ between learning and nonlearning conditions. Results indicate that spindle activity during non-REM sleep is sensitive to previous learning experience.
Common mechanisms underlying growth cone guidance and axon branching.

During development, growth cones direct growing axons into appropriate targets. However, in some cortical pathways target innervation occurs through the development of collateral branches that extend interstitially from the axon shaft. How do such branches form? Direct observations of living cortical brain slices revealed that growth cones of callosal axons pause for many hours beneath their cortical targets prior to the development of interstitial branches. High resolution imaging of dissociated living cortical neurons for many hours revealed that the growth cone demarcates sites of future axon branching by lengthy pausing behaviors and enlargement of the growth cone. After a new growth cone forms and resumes forward advance, filopodial and lamellipodial remnants of the large paused growth cone are left behind on the axon shaft from which interstitial branches later emerge. To investigate how the cytoskeleton reorganizes at axon branch points, we fluorescently labeled microtubules in living cortical neurons and imaged the behaviors of microtubules during new growth from the axon shaft and the growth cone. In both regions microtubules reorganize into a more plastic form by splaying apart and fragmenting. These shorter microtubules then invade newly developing branches with anterograde and retrograde movements. Although axon branching of dissociated cortical neurons occurs in the absence of targets, application of a target-derived growth factor, FGF-2, greatly enhances branching. Taken together, these results demonstrate that growth cone pausing is closely related to axon branching and suggest that common mechanisms underlie directed axon growth from the terminal growth cone and the axon shaft.
Biological consequences of petite mutations in Candida glabrata.

OBJECTIVES To define the pathogenicity of respiration-deficient mutants of Candida glabrata, which present a reduced susceptibility to azoles, that are easily induced in vitro by exposure to these drugs or to ethidium bromide and that may be selected in vivo in patients receiving fluconazole. METHODS Two wild-type isolates of C. glabrata were compared with their respective fluconazole- or ethidium bromide-induced petite mutants, regarding the carbohydrate and protein composition of the cell wall, as well as their surface physical properties, and also their adherence abilities and virulence in mice. RESULTS Flow cytometric analysis of cell wall carbohydrates using several fluorescent lectins showed an increased binding of mutant cells to concanavalin A compared with their parent isolates, suggesting a greater availability or an increased amount of glucose-mannose residues at the cell surface in petite mutants. Likewise, some quantitative differences between parent and mutant isolates were shown by SDS-PAGE in protein extracts from blastoconidia. Regarding the surface physical properties, no significant differences were seen in the electrophoretic mobility determined by microelectrophoresis, but the two-phase partitioning method revealed a lower cell surface hydrophobicity for petite mutants. Moreover, mutant cells exhibited significant overexpression of CgEPA1 as revealed by real-time reverse transcription-PCR, but the adherence capacities to Caco-2 cells, a human enterocyte line, were not significantly different. Finally, in agreement with their slower growth, petite mutants were less virulent than parent isolates in a murine model of systemic infection. CONCLUSION This low virulence in mice suggests that petite mutants could be disregarded clinically although they may arise during fluconazole therapy.
Childhood maltreatment in adult offspring of Portuguese war veterans with and without PTSD

Background The colonial war that Portugal was involved in between 1961 and 1974 had a significant impact on veterans and their families. However, it is unclear what the consequences of this war are, in particular with regard to levels of childhood maltreatment (CM) in offspring. Objective Our study aims to analyze the influences of fathers’ war exposure and posttraumatic stress disorder (PTSD) on the offspring's CM and simultaneously test the hypothesis of the intergenerational transmission of father–child CM. Method Cross-sectional data were collected, using the Childhood Trauma Questionnaire—Short Form, from 203 adult children and 117 fathers. Subjects were distributed according to three conditions based on the father's war exposure status: did not participate in war, or non-war-exposed (NW); participated in war, or war-exposed (W); and war-exposed with PTSD diagnosis (WP). The data were examined using correlations, variance/covariance, and regression analyses. Results Children of war veterans with PTSD reported more emotional and physical neglect, while their fathers reported increased emotional and physical abuse exposure during their own childhood. Significant father–child CM correlations were found in the war veteran group but less in the war veteran with PTSD group. Father CM predicted 16% of offspring CM of children of war veterans. Conclusions The father's war-related PTSD might be a risk factor for offspring neglect but potentially a protective one for the father–child abuse transmission. War-exposed fathers without PTSD did transmit their own CM experiences more often. Therefore, father's war exposure and father's war PTSD may each be important variables to take into account in the study of intergenerational transmission of CM.
Cloning and characterisation of the rad9 DNA repair gene from Schizosaccharomyces pombe

The rad9.192 DNA repair mutant from the fission yeast, Schizosaccharomyces pombe, is sensitive to both UV and ionising radiation. The rad9 gene has been cloned by complementation of the gamma-ray sensitivity of the mutant cell line. A 4.3 kb HindIII fragment was found to confer resistance to both types of radiation. The region of complementation was further localised to a 2.6 kb HindIII-EcoRV fragment, which, by DNA sequence analysis, was found to contain sequences capable of coding for a 427 amino acid protein, if three introns were postulated to remove stop codons. The introns were confirmed by sequence analysis of cDNA clones and PCR products derived from cDNA. The product of transcription is a 1.6 kb mRNA of low abundance. The putative rad9 protein shows no homology to any published sequence. A truncated protein is capable of complementing the radiation sensitivity of the rad9.192 mutant. Deletion of the gene is not lethal and the null allele has a similar phenotype to the rad9.192 mutant.
Homing in Pacific salmon: mechanisms and ecological basis

Pacific salmon (Oncorhynchus spp.) are famous for their homing migrations from oceanic feeding grounds to their natal river to spawn. During these migrations, salmon travel through diverse habitats (e.g. oceans, lakes, rivers), each offering distinct orientation clues and, perhaps, requiring distinct sensory capabilities for navigation. Despite these challenges, homing is generally precise and this philopatry has resulted in reproductively isolated spawning populations with specialized adaptations for their natal habitat. This paper reviews the mechanisms underlying all aspects of salmon homing but emphasizes the final, freshwater phase governed by olfactory recognition of homestream water. Prior to their seaward migration, juvenile salmon learn (imprint on) odors associated with their natal site and later, as adults, use these odor memories for homing. Our understanding of this imprinting process is derived primarily from studies using artificial odorants and hatchery-reared salmon. Recent findings suggest, however, that such studies may underestimate the complexity of the imprinting process in nature.
Genome size variation in the Arternisia arborescens complex ( Asteraceae , Anthemideae ) and cultivars

Different wild Mediterranean populations of Artemisia arborescens from diverse locations, representing its geographical distribution, as well as some of its well-known cultivars and some specimens cultivated as omamentals in gardens, streets, roads and nurseries, were analysed for genome size estimation. Other closely related species endemic to Macaronesia, A. canariensis, A. argentea and A. gorgonum, were also measured, and their nuclear DNA amount has been related to the biogeography of this group of species. Additionally, five populations of the closely related A. absinthium were analysed to establish comparisons. Measurements, acquired by flow cytometry, ranged from 8.29 pg to 11.61 pg for 2C values. Statistically significant differences of nuclear DNA amounts with respect to factors such as insularity or domestication have been detected. However, a quite low intraspecific genome size variation has been detected in these species. Furthermore, the study also addressed the possible hybrid origins, and possible misidentifications of some of the supposed cultivars ofA. arborescens.
Nowcasting Disaster Damage

Could social media data aid in disaster response and damage assessment? Countries face both an increasing frequency and intensity of natural disasters due to climate change. And during such events, citizens are turning to social media platforms for disaster-related communication and information. Social media improves situational awareness, facilitates dissemination of emergency information, enables early warning systems, and helps coordinate relief efforts. Additionally, spatiotemporal distribution of disaster-related messages helps with real-time monitoring and assessment of the disaster itself. Here we present a multiscale analysis of Twitter activity before, during, and after Hurricane Sandy. We examine the online response of 50 metropolitan areas of the United States and find a strong relationship between proximity to Sandy's path and hurricane-related social media activity. We show that real and perceived threats -- together with the physical disaster effects -- are directly observable through the intensity and composition of Twitter's message stream. We demonstrate that per-capita Twitter activity strongly correlates with the per-capita economic damage inflicted by the hurricane. Our findings suggest that massive online social networks can be used for rapid assessment ("nowcasting") of damage caused by a large-scale disaster.
Federal Reserve Bank of New York Staff Reports Arm’s-Length Transactions as a Source of Incomplete Cross-Border Transmission: The Case of Autos

A growing share of international trade occurs through intra-firm transactions—those between domestic and foreign subsidiaries of a multinational firm. The difficulties associated with writing and enforcing a vertical contract compound when a product must cross a national border, and may explain the high rate of multinational trade across such borders. We show that this common cross-border organization of the firm may have implications for the well-documented incomplete transmission of shocks across borders. We present new evidence of a positive relationship between an industry’s share of multinational trade and its rate of exchange rate pass-through to prices. We then develop a structural econometric model with both manufacturers and retailers to quantify how firms’ organization of their activities across borders affects their pass-through of a foreign cost shock. We apply the model to data from the auto market. Counterfactual experiments show why cross-border transmission may be much higher for a multinational transaction than for an arm’s-length transaction. In the structural model, firms’ pass-through of foreign cost shocks is on average 29 percentage points lower in arm’s-length transactions than in multinational transactions because the higher markups from a double optimization along the distribution chain create more opportunity for markup adjustment following a shock. Since arm’s-length transactions account for about 60 percent of U.S. imports, this difference may explain up to 20 percent of the incomplete transmission of foreign-cost shocks to the United States in the aggregate.
Participatory Planning of Social and Spatial Organization in Agrarian Reform Policy in Brazil: An Assessment of the Implementation Challenges

The social endeavors for Agrarian Reform in Brazil have a history of at least sixty years. Throughout this time, distinct political regimes, increased land concentration, disordered urbanization and the development of a dynamic agribusiness sector inserted in global economy led to both the aggravation of social conflicts over land in Northern and Southern Brazil as well as new inquiries on the features necessary for an efficient Agrarian Reform Plan in the authors' country. Focused on the agrarian reform projects in the Brazilian Amazon, this work discusses on the political and methodological perspectives drawn in II PNRA (second National Plan of Agrarian Reform). The authors frame their account mostly along the theoretical scaffolding provided by the Bloomington School of Institutional Analysis. The authors analyze the multiple challenges facing the organization and the maintenance of the institutional structure designed to facilitate participatory planning and governance of collective resources in periurban settlements. The authors portrait these settlements as highly complex socio-ecological systems wherein socioeconomic asymmetries, cultural diversity and poor social capital and education promote political and ideological disputes that jeopardize safeguarding global commons.
Automatic Segmentation of the Pelvic Bones from CT Data Based on a Statistical Shape Model

We present an algorithm for automatic segmentation of the human pelvic bones from CT datasets that is based on the application of a statistical shape model. The proposed method is divided into three steps: 1) The averaged shape of the pelvis model is initially placed within the CT data using the Generalized Hough Transform, 2) the statistical shape model is then adapted to the image data by a transformation and variation of its shape modes, and 3) a final free-form deformation step based on optimal graph searching is applied to overcome the restrictive character of the statistical shape representation. We thoroughly evaluated the method on 50 manually segmented CT datasets by performing a leave-one-out study. The Generalized Hough Transform proved to be a reliable method for an automatic initial placement of the shape model within the CT data. Compared to the manual gold standard segmentations, our automatic segmentation approach produced an average surface distance of 1.2 ± 0.3mm after the adaptation of the statistical shape model, which could be reduced to 0.7±0.3mm using a final free-form deformation step. Together with an average segmentation time of less than 5 minutes, the results of our study indicate that our method meets the requirements of clinical routine.
How “Regular” Is Sentence Comprehension in Broca's Aphasia? It Depends on How You Select the Patients

Grodzinsky, Piñango, Zurif, and Drai (1999) argue that a statistical analysis of pooled sentence comprehension data from published studies of Broca's aphasic patients supports the dominance of a differential pattern of performance on active and passive voice structures. They argue that these results counter a previous study in which individual patient data from published studies were analyzed. However, Grodzinsky et al. have not carried out a true test of their hypothesis, but have biased the outcome by selecting samples for analysis that support their claims.
Determinants of dermal exposure among Nicaraguan subsistence farmers during pesticide applications with backpack sprayers.

OBJECTIVES Identification of pesticide exposure determinants has become an issue in explaining exposure variability and improving control measures. Most studies have been conducted in industrialized countries. The aim of this study was to identify relevant dermal exposure determinants among Nicaraguan subsistence farmers. METHODS Field data on possible determinants were collected during 32 pesticide applications through observation and supplementary videorecording. A multistep reduction strategy brought down the 110 potential exposure determinants to 27 variables, which were grouped as worksite, spray equipment, working practices, clothing or hygiene practices related. Dermal exposure was quantified with a modification of Fenske's visual scoring method. Multivariate linear regression modeling within groups and across groups was performed. RESULTS In the within-group analyses, work practices, spray equipment and worksite related determinants explained 52, 33 and 25% of the exposure variability, respectively. Clothing and hygiene practices were weaker determinants and did not always reduce the exposure. The final model included determinants from all groups except hygiene practices and explained 69% of the exposure variability. A less restricted model increased the explained variability to 75%. Several novel determinants were identified, including spraying on a muddy terrain, dew on plants, sealing the tank lid with a cloth and wiping sweat from the face. CONCLUSIONS This study showed that a combination of observation and visual scoring techniques can provide valuable information on determinants of pesticide exposure and affected body parts under developing country conditions. The results could be used to develop job-specific questionnaires and to design training and preventive programs.
Comparison of Endothelial Progenitor Cells in Parkinson's Disease Patients Treated with Levodopa and Levodopa/COMT Inhibitor

Background Levodopa treatment in Parkinson's disease (PD) increases in serum homocysteine levels due to its metabolism via catechol O-methyltransferase. Endothelial progenitor cells (EPCs) have the capacity to differentiate into mature endothelial cells and are markers for endothelial functions and cardiovascular risks. Along with traditional vascular risk factors, hyperhomocysteinemia is known to decrease the level of EPCs. In the present study, we hypothesized that that levodopa-induced hyperhomocysteinemia leads to a change in EPC levels. Methodology/Principal Findings We prospectively enrolled PD patients who had been prescribed either levodopa/carbidopa (PD-L group, n = 28) or levodopa/carbidopa/COMT inhibitor (PD-LC group, n = 25) for more than 1 year. The number of circulating EPCs was measured by flow cytometry using dual staining of anti-CD34 and anti-KDR antibodies. The EPCs were divided into tertiles based on their distributions and a logistic regression analysis was used to estimate independent predictors of the highest tertile of EPCs. The number of endothelial progenitor cells was significantly decreased in PD-L patients (118±99/mL) compared with either PD-LC patients (269±258/mL, p = 0.007) or controls (206±204/mL, p = 0.012). The level of homocysteine was significantly increased in PD-L patients (14.9±5.3 µmol/L) compared with either PD-LC patients (11.9±3.0 µmol/L, p = 0.028) or controls (11.1±2.5 µmol/L, p = 0.012). The level of homocysteine was negatively correlated with endothelial progenitor cell levels (r = −0.252, p = 0.028) and was an independent predictor of the highest tertile of endothelial progenitor cell levels (OR; 0.749 [95% CI: 0.584–0.961]). Conclusions/Significance These data indicate that a higher consumption of EPC for restoration of endothelial damage may be associated with chronic levodopa treatment in PD patients.
Diversity of sexual systems within different lineages of the genus Silene

Species or populations may be categorized by sexual system. Here, we examine the frequency of sexual systems in Silene. We found that hermaphroditism is the most common sexual system, followed by dioecy, gynodioecy and gynodioecy-gynomonoecy (females, hermaphrodites and gynomonoecious plants) with similar frequency. These sexual systems are equally represented in the two phylogenetically supported subgenera Silene and Behenantha. We specifically studied the sexual systems of section Psammophilae (four species and 26 populations), and found that most populations are gynodioecious-gynomonoecious. Hermaphrodites are the most common sexual morph, and females tend to produce fewer flowers than other morphs.