Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety and compliance of intravenous and oral dosing regimens.

The Oncologist 2005;10:313–314 www.TheOncologist. com The recent article by Conte and Guarneri highlights numerous safety and compliance issues of intravenous and oral bisphosphonates in patients with metastatic bone disease [1]. I believe it is essential that readers of The Oncologist are made aware of a few of the inaccuracies within the article, particularly those renal safety statements that contradict the approved product labeling for ibandronate. First, the authors imply that the nephrotoxic potentials of intravenous bisphosphonates are similar. This is misleading. The product labeling for zoledronic acid contains a number of renal safety cautions not contained in the label of other bisphosphonates like ibandronate. In 2004, the US labeling for zoledronic acid was updated three times to provide additional safety guidance, and renal safety letters were sent to European physicians [2-4]. Various studies have reported renal safety issues with zoledronic acid [5-11], yet these are not discussed by Conte and Guaneri. For example, the Food and Drug Administration has received reports of renal deterioration progressing to renal failure and dialysis with the use of zoledronic acid [6]. Moreover, in a retrospective review, 23% of patients receiving zoledronic acid had substantial deterioration in renal function [8]. In contrast to zoledronic acid, available data suggest that ibandronate has a renal safety profile comparable to placebo [12-15]. Unlike zoledronic acid, monitoring of renal function is not required prior to each infusion of ibandronate. The approved product labeling for ibandronate in the European Union states that “according to clinical assessment of the individual patient, it is recommended that renal function, serum calcium, phosphate and magnesium should be monitored in patients treated with ibandronate” (i.e., monitoring with ibandronate is at the discretion of the physician) [12]. The statements by Conte and Guarneri about the use of ibandronate in patients with severe renal impairment (page 32) are somewhat unsubstantiated and imply a lack of clinical efficacy. According to the approved product labeling, both the oral and intravenous formulations of ibandronate can be used with a dose adjustment to compensate for lost renal excretion in patients with severe renal failure (creatinine clearance <30 ml/min), unlike zoledronic acid where it is contraindicated [12, 16]. Clearly, the conclusion of the abstract that “newer, more potent bisphosphonates . can be administered via relatively short i.v. infusions without adversely affecting renal function” is unjustified for zoledronic acid. Due to time constraints, many physicians rely entirely on reading the abstract, hence patient safety could be compromised. It is important that physicians appreciate the differences between bisphosphonates to make informed treatment decisions.
Subretinal Glial Membranes in Eyes With Geographic Atrophy

Purpose Müller cells create the external limiting membrane (ELM) by forming junctions with photoreceptor cells. This study evaluated the relationship between focal photoreceptors and RPE loss in geographic atrophy (GA) and Müller cell extension into the subretinal space. Methods Human donor eyes with no retinal disease or geographic atrophy (GA) were fixed and the eye cups imaged. The retinal posterior pole was stained for glial fibrillary acidic protein (GFAP; astrocytes and activated Müller cells) and vimentin (Müller cells) while the submacular choroids were labeled with Ulex Europaeus Agglutinin lectin (blood vessels). Choroids and retinas were imaged using a Zeiss 710 confocal microscope. Additional eyes were cryopreserved or processed for transmission electron microscopy (TEM) to better visualize the Müller cells. Results Vimentin staining of aged control retinas (n = 4) revealed a panretinal cobblestone-like ELM. While this pattern was also observed in the GA retinas (n = 7), each also had a distinct area in which vimentin+ and vimentin+/GFAP+ processes created a subretinal membrane. Subretinal glial membranes closely matched areas of RPE atrophy in the gross photos. Choroidal vascular loss was also evident in these atrophic areas. Smaller glial projections were noted, which correlated with drusen in gross photos. The presence of glia in the subretinal space was confirmed by TEM and cross cross-section immunohistochemistry. Conclusions In eyes with GA, subretinal Müller cell membranes present in areas of RPE atrophy may be a Müller cell attempt to replace the ELM. These membranes could interfere with treatments such as stem cell therapy.
The deaf child in the family and at school : essays in honor of Kathryn P. Meadow-Orlans

Contents: Dedication. D.F. Moores, Foreword. Introduction to the Book. Part I: The Deaf Child in the Family. M.A. Sheridan, Images of Self and Others: Stories From the Children. M.V. Swisher, Learning to Converse: How Deaf Mothers Support the Development of Attention and Conversational Skills in Their Young Deaf Children. C.J. Erting, C. Thumann-Prezioso, B.S. Benedict, Bilingualism in a Deaf Family: Fingerspelling in Early Childhood. L.S. Koester, H. Papousek, S. Smith-Gray, Intuitive Parenting, Communication, and Interaction With Deaf Infants. A.R. Lederberg, A.K. Prezbindowski, Impact of Child Deafness on Mother-Toddler Interaction: Strengths and Weaknesses. A. Steinberg, Autobiographical Narrative on Growing up Deaf. Part II: The Deaf Child and Family in Transition. P.E. Spencer, Every Opportunity: A Case Study of Hearing Parents and Their Deaf Child. D.M. Mertens, M. Sass-Lehrer, K. Scott-Olson, Sensitivity in the Family-Professional Relationship: Parental Experiences in Families With Young Deaf and Hard of Hearing Children. H. Mohay, Language in Sight: Mothers' Strategies for Making Language Visually Accessible to Deaf Children. R. Calderon, M.T. Greenberg, Challenges to Parents and Professionals in Promoting Socioemotional Development in Deaf Children. Part III: The Deaf Child at School. M.S. Stinson, S. Foster, Socialization of Deaf Children and Youths in School. J.E. Nash, Shifting Stigma From Body to Self: Paradoxical Consequences of Mainstreaming. R. Stone, A Bold Step: Changing the Curriculum for Culturally Deaf and Hard of Hearing Students. B. Dyssegaard, Emerging Educational Programs for Deaf Students in Mongolia and Nepal: A Special Report. C.T. Akamatsu, C. Musselman, With A. Zwiebel, Nature Versus Nurture in the Development of Cognition in Deaf People. M. Marschark, Education and Development of Deaf Children--or Is It Development and Education? K.P. Meadow-Orlans, Afterword: Deafness and Social Change: Ruminations of a Retiring Researcher.
Restricting backtracking in connection calculi

Connection calculi benefit from a goal-oriented proof search, but are in general not proof confluent. A substantial amount of backtracking is required, which significantly affects the time complexity of the proof search. This paper presents a simple strategy for effectively restricting backtracking in connection calculi. In combination with a few basic techniques it provides the basis for a refined connection calculus. The paper also describes how this calculus can be implemented directly by a few lines of Prolog code. This very compact program is the core of an enhanced version of the automated theorem prover leanCoP. The performance of leanCoP is compared with other lean theorem provers, connection provers, and state-of-the-art theorem provers. The results show that restricted backtracking is a successful technique when performing proof search in connection calculi.
KIT receptor is expressed in more than 50% of early-stage malignant melanoma: a retrospective study of 261 patients

The c-kit gene encodes a transmembrane receptor (KIT) with tyrosine kinase activity which is a specific target for anti-cancer therapy. We investigated KIT expression in a group of patients with early-stage malignant melanoma. Primary tumour specimens obtained from 261 radically resected patients with stage I and II malignant melanoma were examined for KIT expression. Formalin-fixed, paraffin embedded tissues were stained with the polyclonal rabbit anti-human anti-KIT antibody (Dako Cytomation Inc., Carpenteria, California, USA). Patients were classified into four groups according to the level of expression (0%, <30%, 30–60% and >60%). Univariate and multivariate analyses examining the impact of KIT expression, Breslow thickness, Clark level and microscopic ulceration on disease-free survival were performed. Within the population of 261 patients with early-stage melanoma with 62 recurrences during a follow-up of 64 months, KIT expression was found in 144 cases (55%). KIT was expressed in more than 60% of cells in 20 patients (8%), in 30–60% of cells in 64 patients (24%) and in less than 30% of cells in 60 patients (23%). KIT expression was not found in 117 patients (45%). In univariate analyses, the influence of KIT expression on disease-free survival was not proven (P=0.4956; log-rank test). Increasing Breslow thickness, a higher Clark level, the presence of microscopic ulceration and a higher stage were significantly associated with a shorter disease-free survival (P<0.0001; log-rank test in all cases). In multivariate analysis, Breslow thickness, stage and KIT expression were significant negative prognostic factors for a shorter disease-free survival (P<0.0001, P=0.0028, P=0.0488, respectively; stepwise Cox regression model). It can be concluded that KIT is expressed in more than one-half of early-stage malignant melanoma. KIT may serve as an additive prognostic factor to Breslow thickness and stage within the tested population. The therapeutic impact of KIT expression in malignant melanoma is uncertain. Results of ongoing pilot phase II studies may validate the efficacy of imatinib mesylate in malignant melanoma expressing KIT.
Peningkatan kemampuan berpikir kreatif dan pemecahan masalah matematis siswa SMA melalui model problem based learning menggunakan software autograph

The aim of this research are to determine: (1) the enhancement of the creative thinking and mathematic problem solving ability of Senior High School Students through problem based learning using Autograph software and regular learning. (2) the interaction between the students initial ability and the learning model used toward the students ability of mathematic creatively thinking. (3) the interaction between the students initial ability and the learning model used toward the students ability of mathematic problem solving. (4) the completion process of the students creative thinking and mathematic problem solving ability through problem based learning using autograph software. This was quasi experimental research in Panca Budi Senior High School Medan. The group of the experiment sample and the control group are chosen by random. There are two classes are taken randomly. The experiment class gets Problem Based Learning using Autograph software and the control class gets Problem Based Learning. The instrument is the ability creative thinking and the mathematic problem solving. The reliability for creatively thinking ability and mathematic problem solving is 0.833 and 0.842. The data was analyzed by using Manova to see the enhancement of students creative thinking and mathematic problem solving ability through problem based learning using Autograph software. Anova test is used to determine the interaction between the students initial ability and the model learning used. Descriptive analysis is used to see the process of the enhancement of students ability creative thinking and the ability to solve the mathematic problem through problem based learning using Autograph software. The result showed that: (1) the enhancement of students creative thinking and mathematic problem solving ability that get Problem Based Learning using Autograph Software is better, with value increasing 0.8 and 0.7 in high category and 0.3 and 0.3 in medium category for regular class. (2) There is no interaction between the students initial ability and the learning model used toward the students creative thinking ability (3) There is no interaction between the students initial ability and the learning model used toward the students problem solving ability. (4) The completion process of the students creative thinking and mathematic problem solving ability through problem based learning using autograph software is better than regular learning.
Bat-transmitted Human Rabies Outbreaks, Brazilian Amazon

We describe 2 bat-transmitted outbreaks in remote, rural areas of Portel and Viseu Municipalities, Pará State, northern Brazil. Central nervous system specimens were taken after patients' deaths and underwent immunofluorescent assay and histopathologic examination for rabies antigens; also, specimens were injected intracerebrally into suckling mice in an attempt to isolate the virus. Strains obtained were antigenically and genetically characterized. Twenty-one persons died due to paralytic rabies in the 2 municipalities. Ten rabies virus strains were isolated from human specimens; 2 other cases were diagnosed by histopathologic examination. Isolates were antigenically characterized as Desmodus rotundus variant 3 (AgV3). DNA sequencing of 6 strains showed that they were genetically close to D. rotundus–related strains isolated in Brazil. The genetic results were similar to those obtained by using monoclonal antibodies and support the conclusion that the isolates studied belong to the same rabies cycle, the virus variants found in the vampire bat D. rotundus.
The Relationship between Novice and Experienced Teachers' Self-Efficacy for Classroom Management and Students' Perceptions of their Teachers' Classroom Management

This study investigates the effect of teachers’self-efficacy on classroom management and students’ perceptions of their teachers’classroom management. The study involves 18 novice and 18 experienced English teachers teaching at Ilam high schools and their 120 students from March to September of 2014.Data were collected through two questionnaires.Boththe teacher and student questionnaires consist of 36 Likert scale items. To analyze the data, t-tests were applied. The results revealed that teachers have high efficacy for classroom management. When the two groups werecompared, novice and experienced teachers were found to differ in their self-efficacy forclassroom management, but not in their efficacy for personal teaching and externalinfluences. Students did not distinguish between novice and experienced teachers’classroom management, viewing both positively. In order to improve teachers' efficacy for classroom management, in-servicetraining programs and regular meetings where teachers share their experiences can beheld. Teachers may also spare time for class discussions or administering questionnairesto their students to learn about their students' perceptions of their own teaching andclassroom management practices. Keywords: Self-efficacy, classroom management, misbehavior, novice teachers, experienced teachers
Ringing Down Time Measurement of a Receive Coil for NMR Tomography

The paper describes studies dealing with problems of the receive coil for NMR scanner connected via a preamplifier with high input impedance. Behaviour of the coil with preamplifier after pulses of RF signal was studied and an equation was derived and verified for investigation of it. The theory is demonstrated on a one-turn surface coil with rather large dimensions. Some parameters of a coil are measureable with difficulties and the derived theory can help to determine them more accurately. The technique of the high–impedance preamplifiers is seldom in experimental systems, though it can simplify their adjustment.
Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations

The solution dynamics of antibodies are critical to antibody function. We explore the internal solution dynamics of antibody molecules through the combination of time-resolved fluorescence anisotropy experiments on IgG1 with more than two microseconds of all-atom molecular dynamics (MD) simulations in explicit water, an order of magnitude more than in previous simulations. We analyze the correlated motions with a mutual information entropy quantity, and examine state transition rates in a Markov-state model, to give coarse-grained descriptors of the motions. Our MD simulations show that while there are many strongly correlated motions, antibodies are highly flexible, with Fab and Fc domains constantly forming and breaking contacts, both polar and non-polar. We find that salt bridges break and reform, and not always with the same partners. While the MD simulations in explicit water give the right time scales for the motions, the simulated motions are about 3-fold faster than the experiments. Overall, the picture that emerges is that antibodies do not simply fluctuate around a single state of atomic contacts. Rather, in these large molecules, different atoms come in contact during different motions.
“Same Same” But Different?: Can Work Engagement Be Discriminated from Job Involvement and Organizational Commitment?

The present study investigates whether work engagement (measured by the Utrecht Work Engagement Scale; UWES) could be empirically separated from job involvement and organizational commitment. In addition, psychometric properties of the Swedish UWES were investigated. Discriminant validity of the UWES was tested through inspection of latent intercorrelations between the constructs, confirmatory factor analyses, and patterns of correlations with other constructs (health complaints, job and personal factors, and turnover intention) in a sample of Information Communication Technology consultants (N = 186). Conclusion: Work engagement, job involvement, and organizational commitment are empirically distinct constructs and, thus, reflect different aspects of work attachment. The internal consistency of the Swedish UWES was satisfactory, but the dimensionality was somewhat unclear.
Further investigation of a chromosome 15 locus in schizophrenia: analysis of affected sibpairs from the NIMH Genetics Initiative.

Linkage of a neurophysiological deficit associated with schizophrenia, i.e., the failure to inhibit the auditory P50 response, was previously reported at chromosome 15q14. The marker with the highest pairwise lod score, D15S1360, was isolated from a yeast artificial chromosome containing a candidate gene, the alpha7-nicotinic acetylcholine receptor gene. In the present study, this linkage was further investigated in a subset of the NIMH Genetics Initiative schizophrenia families. These families have not been studied neurophysiologically, as were the families in the original report. Therefore, the DSMIII-R diagnosis of schizophrenia was used as the affected phenotype. Twenty families fulfilled the criteria of at least one sibpair concordant for schizophrenia, along with their two parents or another affected relative outside the nuclear family, available for genotyping. Sibpair analysis showed a significant proportion of D15S1360 alleles shared identical-by-descent (0.58; P < 0.0024). The results further support the involvement of this chromosomal locus in the genetic transmission of schizophrenia.
Enhancing organisational performance through information technology: an organisational and social strategic context

Motivated by the increasing significance of information technology IT in today's open system organisations, the objective of this research is to uncover the relationships between business executives and their IT counterparts, which are essential toward improving organisational performance. In the process, a structural equation modelling is utilised to analyse the responses of a sample of 141 Portuguese executives. The results of testing the nine research hypotheses tend to underscore the significance of the trust between business and IT executives. Such trust is capable of fostering an organisational culture, which is conducive to the enhancement of the organisational performance. The ability of these business and IT executives to work together cultivates a knowledge domain, which generates effective solutions and applications to organisational problems. In turn, this contributes to improving the competitive performance of the organisation.
An Evaluation of Foster Parents' Attitudes Towards Birth Parents

Although foster care involves many different relationships that have been examined for many years, few researchers have paid attention to the relationship that must inevitably develop between the foster parents and the child's birth parents. Foster parents have, nonetheless, been noted to express negative feelings about the behaviour of the foster child's natural family. This may have negative effects on the development of the child's self esteem and on the outcome of the entire placement. The cun'ent paper illustrates how the foster parents of 127 placements in Cork city described the birth parents of their foster children. Although 38% of placements were with parents who expressed some degree of sympathy for the birth parents, the attitude was generally more negative. This was true even of foster parents who never met the child. Parents also reported that they experienced various problems with the natural parents. These included concerns over the care that was taken of the child, that the natural parents were untrustwOlthy, and that the child would not be released for adoption . Examples of the statements that were made are offered, and some cases are described to help illustrate the frustration that some foster parents felt. It was found that one of the most emotive issues was that of adoption, Many foster parents felt upset when the birth parents refused to release the foster child for adoption. The implications of these poor relationships are discussed in relation to the need for more resources for health boards, and more support for foster parents and natural parents.
Reciprocal development of parent-adolescent support and adolescent problem behaviors

Human development takes place in the context of relationships with others.These relationships are thought to influence individuals’ behavior and developmental course (Reis, Collins, & Berscheid, 2000). Parent–child relationshipsare among the most important and central of human relationships, especiallyduring the period of childhood and adolescence. Parents are an importantsource of support, although the relative impact of parental support may changeover the life course. Perceived parental support concerns the perception ofparents as available for support when needed. In the current chapter we willexamine how parental support is related to adolescent adjustment over time.
EFFECT OF TULSI LEAF EXTRACT ON PHYSICO-CHEMICAL AND MICROBIAL QUALITY OF RAW MILK

A study was conducted to assess the effect of tulsi leaf extract on physicochemical and microbial quality of raw milk. Raw milk collected hygienically from an organized dairy farm was assessed by addition of aqueous extracts of tulsi leaves at different concentrations viz., 0.25, 0.5, 0.75 and 1 per cent and studied for physico-chemical and microbial parameters at regular intervals at 37 °C. It was found that addition of aqueous extract of tulsi leaves extracts at 0.5 per cent (v/v) extended the shelf life of raw milk by 5 hours by clot on boiling test. There was a controlled increase in pH and titratable acidity in the milk samples added with 0.5%, 0.75% and 1% level of tulsi leaves extract. The Statistical analysis of data revealed that standard plate count of the aqueous extract of tulsi leaves treated raw milk showed highly significant difference (P ≤0.01) was noticed within treatments during the storage as well as between treatments from 3 to 12 hours of storage.