Miracle-dz/UniFAR-FTUs huggingface dataset:
Adolescent Relationship Quality: Is There an Intergenerational Link?

Objective This study examines intergenerational continuities in relationship instability, general relationship quality, and intimate partner violence (IPV) between mothers and adolescents. Background A growing body of literature has observed similarities in relationship quality between parents and their adult offspring. Less attention has focused on whether intergenerational continuities are present in adolescent relationships. Method Using age 3, 5, 9, and 15 data from the Fragile Families and Child Wellbeing birth cohort study (N=3,162), the authors examined associations between maternal reports of relationship instability, general quality, and IPV in early and middle childhood and similar adolescent reports at age 15. Variations based on timing and persistence of exposures were considered. Results In general, exposures to low-quality maternal relationships were associated with higher risk of forming adolescent partnerships and lower relationship quality. Intergenerational links in quality were predominantly construct-specific, consistent with observational learning processes. Adolescents exposed to maternal relationships of poor general quality in middle childhood were less likely to report high-quality relationships themselves, and those exposed to any maternal physical IPV victimization during childhood were more likely to perpetrate IPV in their own relationships. Exposure to maternal relationship instability in both early and middle childhood was associated with more adolescent romantic partners. Conclusion The study illuminates additional pathways through which healthy and unhealthy relationships are reproduced across generations.
Linguistic immersion and structural effects on the bilingual brain: a longitudinal study

Learning and using additional languages can result in structural changes in the brain. However, the time course of these changes, as well as the factors the predict them, are still not well understood. In this longitudinal study we test the effects of bilingual immersion on brain structure of adult sequential bilinguals not undergoing any language training, who were scanned twice, three years apart. We observed significant increases in grey matter volume in the lower left cerebellum, mean white matter diffusivity in the frontal cortex, and reshaping of the left caudate nucleus and amygdala and bilateral hippocampus. Moreover, both prior length of immersion and L2 age of acquisition were significant predictors of volumetric change in the cerebellum. Taken together, these results indicate that bilingualism-induced neurological changes continue to take place across the lifespan and are strongly related to the quantity and quality of bilingual immersion, even in highly-immersed adult bilingual populations.
Biomimetic organization: Octapeptide self-assembly into nanotubes of viral capsid-like dimension

The controlled self-assembly of complex molecules into well defined hierarchical structures is a promising route for fabricating nanostructures. These nanoscale structures can be realized by naturally occurring proteins such as tobacco mosaic virus, capsid proteins, tubulin, actin, etc. Here, we report a simple alternative method based on self-assembling nanotubes formed by a synthetic therapeutic octapeptide, Lanreotide in water. We used a multidisciplinary approach involving optical and electron microscopies, vibrational spectroscopies, and small and wide angle x-ray scattering to elucidate the hierarchy of structures exhibited by this system. The results revealed the hexagonal packing of nanotubes, and high degree of monodispersity in the tube diameter (244 Å) and wall thickness (≈18 Å). Moreover, the diameter is tunable by suitable modifications in the molecular structure. The self-assembly of the nanotubes occurs through the association of β-sheets driven by amphiphilicity and a systematic aromatic/aliphatic side chain segregation. This original and simple system is a unique example for the study of complex self-assembling processes generated by de novo molecules or amyloid peptides.
Measuring the effect of fuel treatments on forest carbon using landscape risk analysis

Abstract. Wildfire simulation modelling was used to examine whether fuel reduction treatments can potentially reduce future wildfire emissions and provide carbon benefits. In contrast to previous reports, the current study modelled landscape scale effects of fuel treatments on fire spread and intensity, and used a probabilistic framework to quantify wildfire effects on carbon pools to account for stochastic wildfire occurrence. The study area was a 68 474 ha watershed located on the Fremont-Winema National Forest in southeastern Oregon, USA. Fuel reduction treatments were simulated on 10% of the watershed (19% of federal forestland). We simulated 30 000 wildfires with random ignition locations under both treated and untreated landscapes to estimate the change in burn probability by flame length class resulting from the treatments. Carbon loss functions were then calculated with the Forest Vegetation Simulator for each stand in the study area to quantify change in carbon as a function of flame length. We then calculated the expected change in carbon from a random ignition and wildfire as the sum of the product of the carbon loss and the burn probabilities by flame length class. The expected carbon difference between the non-treatment and treatment scenarios was then calculated to quantify the effect of fuel treatments. Overall, the results show that the carbon loss from implementing fuel reduction treatments exceeded the expected carbon benefit associated with lowered burn probabilities and reduced fire severity on the treated landscape. Thus, fuel management activities resulted in an expected net loss of carbon immediately after treatment. However, the findings represent a point in time estimate (wildfire immediately after treatments), and a temporal analysis with a probabilistic framework used here is needed to model carbon dynamics over the life cycle of the fuel treatments. Of particular importance is the long-term balance between emissions from the decay of dead trees killed by fire and carbon sequestration by forest regeneration following wildfire.
Algorithms for Coxianization of Phase-Type Generators

This paper develops algorithms for finding Coxian generators to phase-type (PH)-majorize a PH-generator T with only real eigenvalues. In the first part of this paper, we investigate matrices S and P satisfying TP = PS and Pe = e. Conditions on T are identified for S to be an ordered Coxian generator and for P to be nonnegative, which consequently implies that SPH-majorizes T. It is shown that every PH-generator with only real eigenvalues is PH-majorized by some Coxian generator. In the second part of this paper, the results on S and P and the conditions on T are used to develop efficient algorithms for Coxianization of PH-generators. Numerical examples are presented for a comparison between the developed algorithms.
Maturation and Death of Adult-Born Olfactory Bulb Granule Neurons: Role of Olfaction

Young neurons born in the subventricular zone (SVZ) of adult mice migrate to the olfactory bulb (OB) where they differentiate into granule cells (GCs) and periglomerular interneurons. Using retroviral labeling of precursors in the SVZ, we describe five stages and the timing for the maturation of newly formed GCs: (1) tangentially migrating neuroblasts (days 2–7); (2) radially migrating young neurons (days 5–7); (3) GCs with a simple unbranched dendrite that does not extend beyond the mitral cell layer (days 9–13); (4) GCs with a nonspiny branched dendrite in the external plexiform layer (days 11–22); and (5) mature GCs (days 15–30). Using [3H]thymidine, we show that the maximum number of labeled GCs is observed around day 15 after injection. Interestingly, between days 15 and 45 after birth, soon after the cells developed spines, the number of [3H]thymidine-labeled GCs declined by 50%. Using anosmic mice, we found that sensory input was critical for the survival of GCs from day 15 to 45 after labeling. However, the number and morphology of 15-d-old cells in the granule cell layer was similar in anosmic and wild-type mice. We infer that the lack of activity did not have an effect on the generation, migration, and early differentiation of granule cells. Soon after young GCs matured, and presumably became synaptically connected, their survival depended on the level of activity that they received. This selection mechanism might allow the construction of specific OB circuits based on olfactory experience and suggests possible functions of OB cell replacement.
Putting Reciprocity to Work - Positive Versus Negative Responses in the Field

We study the role of reciprocity in a labor market field experiment. In a recent paper, Gneezy and List (2006) investigate the impact of gift exchange in this context and find that it has only a transient effect on long run outcomes. Extending their work to examine both positive and negative reciprocity, we find consonant evidence in the positive reciprocity condition: the gift does not work well in the long run (if at all). Yet, in the negative reciprocity treatment we observe much stronger effects: a wage reduction has a significant and lasting negative impact on efforts. Together, these results highlight the asymmetry of positive and negative reciprocity that exists in the field, and provide an indication of the relative importance of each in the long run.
Clinical Application of 1,5-Anhydroglucitol Measurements in Patients with Hepatocyte Nuclear Factor-1α Maturity-Onset Diabetes of the Young

OBJECTIVE—1,5-anhydroglucitol (1,5-AG) is a short-term marker of metabolic control in diabetes. Its renal loss is stimulated in hyperglycemic conditions by glycosuria, which results in a lowered plasma concentration. As a low renal threshold for glucose has been described in hepatocyte nuclear factor-1α (HNF-1α) maturity-onset diabetes of the young (MODY), the 1,5-AG level may be altered in these patients. The purpose of this study was to assess the 1,5-AG levels in patients with HNF-1α MODY and in type 2 diabetic subjects with a similar degree of metabolic control. In addition, we aimed to evaluate this particle as a biomarker for HNF-1α MODY. RESEARCH DESIGN AND METHODS—We included 33 diabetic patients from the Polish Nationwide Registry of MODY. In addition, we examined 43 type 2 diabetic patients and 47 nondiabetic control subjects. The 1,5-AG concentration was measured with an enzymatic assay (GlycoMark). Receiver operating characteristic (ROC) curve analysis was used to evaluate 1,5-AG as a screening marker for HNF-1α MODY. RESULTS—The mean 1,5-AG plasma concentration in diabetic HNF-1α mutation carriers was 5.9 μg/ml, and it was lower than that in type 2 diabetic patients (11.0 μg/ml, P = 0.003) and in nondiabetic control subjects (23.9 μg/ml, P < 0.00005). The ROC curve analysis revealed 85.7% sensitivity and 80.0% specificity of 1,5-AG in screening for HNF-1α MODY at the criterion of <6.5 μg/ml in patients with an A1C level between 6.5 and 9.0%. CONCLUSIONS—1,5-AG may be a useful biomarker for differential diagnosis of patients with HNF-1α MODY with a specific range of A1C, although this requires further investigation. However, the clinical use of this particle in diabetic HNF-1α mutation carriers for metabolic control has substantial limitations.
Effect of P2X7 Receptor Knockout on AQP-5 Expression of Type I Alveolar Epithelial Cells

P2X7 receptors, ATP-gated cation channels, are specifically expressed in alveolar epithelial cells. The pathophysiological function of this lung cell type, except a recently reported putative involvement in surfactant secretion, is unknown. In addition, P2X7 receptor-deficient mice show reduced inflammation and lung fibrosis after exposure with bleomycin. To elucidate the role of the P2X7 receptor in alveolar epithelial type I cells we characterized the pulmonary phenotype of P2X7 receptor knockout mice by using immunohistochemistry, western blot analysis and real-time RT PCR. No pathomorphological signs of fibrosis were found. Results revealed, however, a remarkable loss of aquaporin-5 protein and mRNA in young knockout animals. Additional in vitro experiments with bleomycin treated precision cut lung slices showed a greater sensitivity of the P2X7 receptor knockout mice in terms of aquaporin-5 reduction as wild type animals. Finally, P2X7 receptor function was examined by using the alveolar epithelial cell lines E10 and MLE-12 for stimulation experiments with bleomycin. The in vitro activation of P2X7 receptor was connected with an increase of aquaporin-5, whereas the inhibition of the receptor with oxidized ATP resulted in down regulation of aquaporin-5. The early loss of aquaporin-5 which can be found in different pulmonary fibrosis models does not implicate a specific pathogenetic role during fibrogenesis.
Correlated Multiarmed Bandit Problem: Bayesian Algorithms and Regret Analysis

We consider the correlated multiarmed bandit (MAB) problem in which the rewards associated with each arm are modeled by a multivariate Gaussian random variable, and we investigate the influence of the assumptions in the Bayesian prior on the performance of the upper credible limit (UCL) algorithm and a new correlated UCL algorithm. We rigorously characterize the influence of accuracy, confidence, and correlation scale in the prior on the decision-making performance of the algorithms. Our results show how priors and correlation structure can be leveraged to improve performance.
Cooperative robust output regulation for nonlinear multi-agent systems with unity relative degree subject to a nonlinear leader

In this paper, we study the cooperative global robust output regulation problem for unity relative degree nonlinear multi-agent systems in normal form with a non- linear leader system. The same problem was studied recently under the assumptions that the leader system is linear and the communication network is undirected. By employing a distributed nonlinear internal model, we will construct a control law that accommodates nonlinear leader systems, and directed communication networks. Our result will be illustrated by an example with the well known Van der Pol osicllator as the leader system.
Understanding Information Systems Outsourcing Success and Risks Through the Lens of Cognitive Biases

Because outsourcing of information systems (IS) is now widespread, it is generally assumed to be successful. It is also often assumed that outsourcing risks are easily managed. In this paper we adopt an “evidence based management” approach to first test these assumptions through a qualitative metaanalysis of academic studies into IS outsourcing outcomes. Our research reveals a shortage of reliable and valid evidence for outsourcing’s benefits, and for the level of risk involved. We then use data from a series of focus groups to explain the paradox of widespread adoption of a strategy with limited empirical support. These focus groups were interpreted through the lens of research on a range of cognitive mechanisms and biases that are known to affect decision makers. We conclude that cognitive mechanisms that are likely to affect sourcing decisions include framing biases, cognitive dissonance, attribution error, and the “optimism”, “confirmation”, “disconfirmation” and “overconfidence” biases. Given the shortage of supporting evidence, and the potential for these biases to operate, we argue that researchers need to be more critical in their analysis of reports of the success and risks of IS outsourcing.
Measurement of heartbeat, respiration and movements detection using Smart Bed

Assessment of sleep-stage patterns and sleep disorders with the conventional sensor system uses many electrodes and straps to record the physiological body parameters. This causes inconvenience to the person who undergoes the sleep study. Thus a contactless measurement system would be ideal for measurement of body parameters for sleep-stage pattern analysis. We propose a contactless measurement system called Smart Bed, to detect heartbeat, breathing pattern and body movements using load sensors installed on four legs of the bed. This method uses cardio ballistic force near the thorax region when blood is being pumped out of heart by the left ventricle, known as Ballistocardiography, to measure a heartbeat. A slightly slower frequency variation in the same thorax region caused by breathing effect is measured to get respiration signal. The body movement patterns are also detected along with the other parameters. These parameters have direct influence on sleep disorders & sleep-stage patterns. Conventional sensors are used to correlate the accuracy of detected parameters from load sensors. The Smart Bed can be used in home environment for long term monitoring without any supervision from trained professionals.
EVALUATION OF VOIDS IN THE MINERAL AGGREGATE FOR HMA PAVING MIXTURES

Voids in the mineral aggregate (VMA), together with the voids in the total mix (VTM), are considered important parameters in hot mix asphalt (HMA) mix design. It is believed that a minimum VMA requirement is necessary to ensure that the HMA mix is not deficient in asphalt cement (so the mix is durable), and/or in VTM (to prevent flushing and/or rutting). Current VMA requirements are based largely upon the work done during 1950 to 1960. However, the literature reviewed as part of this study did not indicate the existence of any significant rational data correlating the durability of HMA pavements with the minimum VMA values specified for mix design. This study was undertaken (a) to reexamine the rationale behind the minimum VMA values currently being used, and (b) to quanti~ the relationship between various asphalt film thicknesses and the aging characteristics of the HMA mix, so that an optimum film thickness desirable for satisfactory mix durability could be established. The optimum film thickness could then be used to establish VMA requirements. Mixes prepared with asphalt binder film thickness ranging from about 4 to 13 microns, were subjected to accelerated aging using Strategic Highway Research Program (SHRP) procedures to simulate both short and long term aging. Both the aggregate (RD) and the asphalt ‘Respectively, Associate Director, National Center for Asphalt Technology, and Graduate Student, Auburn University, Alabama. cement (AAM1 ) used in this study were obtained from the SHRP Materials Reference Library. The aged, compacted mix was tested for tensile strength, tensile strain at failure and resilient modulus. The aged asphalt cement was recovered and tested for penetration, viscosity, complex between various asphalt film thicknesses and the aging characteristics of the HMA mix, so that an optimum film thickness desirable for satisfactory mix durability could be established. The optimum film thickness could then be used to establish modulus and phase angle. Aging indices were obtained from these tests, and the relationship between film thickness and the aged mix/aged asphalt cement properties were determined using regression analysis. For the particular aggregate/asphalt cement combination used in this study, it was found that accelerated aging would occur if the asphalt binder film thickness was less than 910 microns in an HMA mixture compacted to 8°/0 air void content. The minimum VMA required to accommodate this optimum asphalt film thickness and 4°/0 air void content, was also calculated.
Effect of Village Health Team Home Visits and Mobile Phone Consultations on Maternal and Newborn Care Practices in Masindi and Kiryandongo, Uganda: A Community-Intervention Trial

Introduction The World Health Organisation recommends home visits conducted by Community Health Workers (in Uganda known as Village Health Teams—VHTs) in order to improve maternal and newborn health. This study measured the effect of home visits combined with mobile phone consultations on maternal and newborn care practices. Method In a community intervention trial design 16 health centres in Masindi and Kiryandongo districts, Uganda were randomly and equally allocated to one of two arms: control and intervention arms. Eight control health centres received the usual maternal and newborn educational messages offered by professional health workers and eight intervention health centres that received an intervention package for maternal care and essential newborn care practices. In the intervention arm VHTs made two prenatal and one postnatal home visit to households. VHTs were provided with mobile phones to enable them make regular telephone consultations with health workers at the health centre serving the catchment area. The primary outcome was health facility delivery. Other outcomes included antenatal attendances, birth preparedness, cord and thermal care and breastfeeding practices. Analysis was by intention-to-treat. Results A total of 1385 pregnant women were analysed: 758 and 627 in the control and intervention arms respectively. Significant post-intervention differences were: delivery place [adjusted Odds Ratio aOR: 17.94(95%CI: 6.26–51.37); p<0.001], cord care [aOR: 3.05(95%CI: 1.81–5.12); p<0.001] thermal care [aOR: 7.58(95%CI: 2.52–22.82); p<0.001], and timely care-seeking for newborn illness [aOR: 4.93(95%CI: 1.59–15.31); p = 0.006]. Conclusion VHTs can have an effect in promoting proper cord and thermal care for the newborn and improve timely care-seeking for health facility delivery and newborn illness, because they could answer questions and refer patients correctly. However, VHTs should be supported by professional health workers through the use of mobile phones. Trial Registration ClinicalTrials.gov NCT02084680
Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability

Successful cell proliferation requires efficient and precise genome duplication followed by accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is also required during mitosis. Tight cell cycle controls over Cdt1 abundance and activity are critical to normal development and genome stability. We review here recent advances in elucidating Cdt1 molecular functions in both origin licensing and kinetochore–microtubule attachment, and we describe the current understanding of human Cdt1 regulation.
Immunopathogenesis of Ocular Behçet's Disease

Behçet's disease (BD) is a chronic recurrent systemic inflammatory disorder of unknown etiology characterized by oral and genital ulcerations, skin lesions, and uveitis. The ocular involvement of BD, or Behçet's uveitis (BU), is characterized by panuveitis or posterior uveitis with occlusive retinal vasculitis and tends to be more recurrent and sight threatening than other endogenous autoimmune uveitides, despite aggressive immunosuppression. Although pathogenesis of BD is unclear, researches have revealed that immunological aberrations may be the cornerstone of BD development. General hypothesis of BD pathogenesis is that inflammatory response is initiated by infectious agents or autoantigens in patients with predisposing genetic factors and perpetuated by both innate and acquired immunity. In addition, a network of immune mediators plays a substantial role in the inflammatory cascade. Recently, we found that the immunopathogenesis of BU is distinct from other autoimmune uveitides regarding intraocular effector cell profiles, maturation markers of dendritic cells, and the cytokine/chemokine environment. In addition, accumulating evidence indicates the involvement of Th17 cells in BD and BU. Recent studies on genetics and biologics therapies in refractory BU also support the immunological association with the pathogenesis of BU. In this review, we provide an overview of novel findings regarding the immunopathogenesis of BU.