Miracle-dz/UniFAR-FTUs huggingface dataset:
Poststroke Disposition and Associated Factors in a Population-Based Study: The Dijon Stroke Registry

Background and Purpose— The organization of poststroke care will be a major challenge in coming years. We aimed to assess hospital disposition after stroke and its associated factors in clinical practice. Methods— All cases of stroke from 2006 to 2010 were identified from the population-based Stroke Registry of Dijon, France. Demographic features, risk factors, and prestroke treatments were recorded. Admission stroke severity was assessed using the National Institutes of Health Stroke Scale score. At discharge, we collected dementia, disability using the modified Rankin Scale, length of stay, and hospital disposition (home, rehabilitation, convalescent home, and nursing home). Multivariate analyses were performed using logistic regression models to identify associated factors of postdischarge disposition. Results— Of the patients with 1069 stroke included, 913 survived acute care. Among them, 433 (47.4%) returned home, whereas 206 (22.6%) were discharged to rehabilitation, 134 (14.7%) were admitted to a convalescent home, and 140 (15.3%) to a nursing home. Old patients, those under anticoagulants before stroke, those with severe stroke on admission, severe disability at discharge, dementia, or prolonged length of stay were less likely to return home. Moreover, advanced age, severe initial stroke, severe disability at discharge, and dementia were associated with admission to convalescent and nursing homes rather than rehabilitation centers. Conclusion— This population-based study demonstrated that postdischarge destinations are associated with several factors. Our findings may be useful to establish health policy concerning the organization of poststroke care.
NIH Peer Review: Challenges and Avenues for Reform

The National Institute of Health (NIH), through its extramural grant program, is the primary public funder of health-related research in the United States. Peer review at NIH is organized around the twin principles of investigator initiation and rigorous peer review, and this combination has long been a model that science funding agencies throughout the world seek to emulate. However, lean budgets and the rapidly changing ecosystem within which scientific inquiry takes place have led many to ask whether the peer-review practices inherited from the immediate post-war era are still well-suited to twenty first century realities. In this essay, we examine two salient issues: (1) the aging of the scientist population supported by NIH and (2) the innovativeness of the research supported by the institutes. We identify potential avenues for reform as well as a means for implementing and evaluating them.
DSMC Grid Methodologies for Computing Low-Density, Hypersonic Flows About Reusable Launch Vehicles

Two different grid methodologies are studied for application to DSMC simulations about reusable launch vehicles. One method uses an unstructured, tetrahedral grid while the other uses a structured, variable-resolution Cartesian grid. The relative merits of each method are discussed in terms of accuracy, computational efficiency, and overall ease of use. Both methods are applied to the computation of a low-density, hypersonic flow about a winged single-stage-to-orbit reusable launch vehicle concept at conditions corresponding to an altitude of 120 km. Both methods are shown to give comparable results for both surface and flowfield quantities as well as for the overall aerodynamic behavior. For the conditions simulated, the flowfield about the vehicle is very rarefied but the DSMC simulations show significant departure from free-molecular predictions for the surface friction and heat transfer as well as certain aerodynamic quantities.
Cell membrane-binding properties of group A streptococcal lipoteichoic acid

Lipoteichoic acid (LTA) was extracted from group A streptococci, previously treated with hot HCl, by the phenol method. The extracted LTA was loaded on an isoelectric (IE) focusing column and two fractions were collected; one at pH 4.65 and the other at pH 2.95. Chemical analysis demonstrated that the unfractionated LTA contained alanine and glycerolphosphate at molar ratio of 1:10, and ester-linked lipids, but no detectable sugars or amino-sugars. The two IE fractions contained lipids but lacked alanine. The LTA and its IE fractions spontaneously adsorbed to human erythrocytes (sensitization) causing them to agglutinate in the presence of rabbit anti-LTA. The RBC-sensitizing and antigenic activities of IE fractions were equal to, or greater (for IE fraction at pH 4.65) than the unfractionated LTA, indicating that alanine is not involved in the sensitizing activity of LTA. Mild ammonia-hydrolysis abolished the RBC-sensitizing activity of LTA and its IE fractions. Chloroform-methanol-soluble material of the ammonia- hydrolysate lacked antigenic activity but blocked sensitization of erythrocytes by LTA. The water-soluble material of the hydrolyzed LTA retained antigenic activity, was not able to block sensitization by LTA, and its sensitizing activity was restored after esterification with fatty acids. These experiments indicate that ester-linked fatty acids (palmitic acid being the major one) are involved in the spontaneous adsorption of LTA to erythrocytes. The LTA, its lipid moiety, and anti-LTA blocked adherence of group A streptococci to human epithelial cells, suggesting that small amounts of LTA may reside on the streptococcal surface to mediate attachment and colonization of these organisms on mucosal surfaces in vivo.
Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro

In vitro intracellular recordings were made from neurons in the rat midbrain slice. Two neuronal types could be distinguished in dopamine- containing (DA) midbrain regions based on electrophysiological criteria. One neuron type exhibited short duration action potentials (less than 1.5 msec), could fire at high frequencies (greater than 10 Hz), and exhibited either phasic or burst firing patterns. This neuron did not exhibit tyrosine hydroxylase immunoreactivity. A second neuronal type exhibited a unique set of electrophysiological properties, which included (1) a spontaneous pacemaker-like depolarizing potential, (2) a highly regular firing pattern, (3) long duration (greater than 2 msec) action potentials, and (4) a high (i.e., depolarized) spike threshold. This neuron was consistently double labeled using intracellular staining and immunocytochemical localization of the catecholamine-specific enzyme tyrosine hydroxylase, and thus represented the DA neuronal type. Midbrain DA neurons stained with Lucifer yellow could be separated into 3 classes based on their location and morphology: (1) fusiform neurons with laterally projecting dendrites in the dorsal substantia nigra zona compacta region, (2) multipolar cells with laterally and ventrally projecting dendrites in the ventral substantia nigra zona compacta, and (3) neurons with fusiform and multipolar somata and radially projecting dendrites in the ventral tegmental area. The dendrites also exhibited spine-like protrusions and ended with specialized forked processes. Spontaneously firing DA cells recorded in vitro had a number of distinguishing electrophysiological characteristics in common with those of DA neurons recorded in vivo, such as the presence of a slow depolarizing potential driving spike activity and a characteristic depolarized spike threshold (approximately-36 mV). However, in contrast to that found in vivo, the DA cells characterized here exhibited substantially higher input resistances and fired spontaneously in a very regular pacemaker pattern. Burst firing was not observed. Spike activity was apparently dependent on 4 depolarizing events: (1) a voltage-dependent TTX- sensitive slow depolarization, (2) a cobalt-sensitive low threshold depolarization that was activated during the rebound from brief membrane hyperpolarizations, (3) high threshold dendritic calcium spikes which gave rise to the spike afterhyperpolarization, and (4) a high threshold initial segment sodium spike. These depolarizations were modulated by several processes, including a 4-aminopyridine-insensitive delayed repolarization, an instantaneous and time-dependent anomalous rectifier, and an afterhyperpolarization. Although low threshold depolarizations and rebound action potentials could be triggered by the membrane repolarization following small membrane hyperpolarizations, comparatively larger hyperpolarizations attenuated this rebound activation, thereby suppressing anodal break excitation. (ABSTRACT TRUNCATED AT 400 WORDS)
Approximate hybrid model predictive control for multi-contact push recovery in complex environments

Feedback control of robotic systems interacting with the environment through contacts is a central topic in legged robotics. One of the main challenges posed by this problem is the choice of a model sufficiently complex to capture the discontinuous nature of the dynamics but simple enough to allow online computations. Linear models have proved to be the most effective and reliable choice for smooth systems; we believe that piecewise affine (PWA) models represent their natural extension when contact phenomena occur. Discrete-time PWA systems have been deeply analyzed in the field of hybrid Model Predictive Control (MPC), but the straightforward application of MPC techniques to complex systems, such as a humanoid robot, leads to mixed-integer optimization problems which are not solvable at real-time rates. Explicit MPC methods can construct the entire control policy offline, but the resulting policy becomes too complex to compute for systems at the scale of a humanoid robot. In this paper we propose a novel algorithm which splits the computational burden between an offline sampling phase and a limited number of online convex optimizations, enabling the application of hybrid predictive controllers to higher-dimensional systems. In doing so we are willing to partially sacrifice feedback optimality, but we set stability of the system as an inviolable requirement. Simulation results of a simple planar humanoid that balances by making contact with its environment are presented to validate the proposed controller.
Quality of life outcome measures following partial glossectomy: assessment using the UW-QOL scale.

BACKGROUND The consequences of a diagnosis of head and neck cancer and the impact of treatment have a clear and direct influence on well-being and associated quality of life (QOL) in these patients. AIMS To determine the QOL in head and neck cancer patients following a partial glossectomy operation. DESIGN AND SETTING Cross-sectional cohort study; Head and Neck Oncology Unit, tertiary referral center. MATERIALS AND METHODS 38 patients with partial glossectomy were assessed with the University of Washington head and neck quality of life (UW-QOL) scale, version 4. STATISTICAL ANALYSIS Statistical analysis was performed using the Statistical Package for Social Sciences 10.0 (SPSS Inc, Chicago version III). Information from the scale was correlated using the Mann Whitney test. A P value less than/equal to 0.05 was considered as significant. RESULTS The mean (sd) composite score of the QOL in our series was 73.6 (16.1). The majority (71.8%) quoted their QOL as good or very good. Swallowing (n = 16, 47.1%), speech (n = 15, 44.1%) and saliva (n = 15, 44.1%) were most commonly cited issues over the last 7 days. On the other hand, the groups with reconstruction, neck dissection, complications and radiotherapy demonstrated a significant reduction of quality of life scores (Mann Whitney test, P < 0.005). CONCLUSION The composite score and overall QOL as assessed using the UW-QOL scale (version 4) were modestly high in our series of partial glossectomy patients. Swallowing, speech, and saliva are regarded as the most important issues. Stage of the disease, neck dissection, reconstruction, complications, radiotherapy and time since operation were seen to significantly affect domain scores.
Costs of Endangered Species Protection on Public Lands: Evidence from Cape Hatteras National Seashore

Management of public lands often involves competing uses and difficult tradeoffs. Here we examine the implications of a direct federal land use conflict in Cape Hatteras National Seashore: off-road vehicle (ORV) access and endangered species protection. Results from a repeated discrete choice model of recreational angler behavior suggest that the economic costs of access restrictions are relatively modest, ranging from $403,000 to $2.07 million annually. Our results provide general support for the National Park Service’s recently implemented ORV management plan, as the upper bound of recreation losses is less than a conservative estimate of the benefits of protecting coastal biodiversity.
A comparison of the Injury Severity Score and the Trauma Mortality Prediction Model

BACKGROUND Performance benchmarking requires accurate measurement of injury severity. Despite its shortcomings, the Injury Severity Score (ISS) remains the industry standard 40 years after its creation. A new severity measure, the Trauma Mortality Prediction Model (TMPM), uses either the Abbreviated Injury Scale (AIS) or DRG International Classification of Diseases—9th Rev. (ICD-9) lexicons and may better quantify injury severity compared with ISS. We compared the performance of TMPM with ISS and other measures of injury severity in a single cohort of patients. METHODS We included 337,359 patient records with injuries reliably described in both the AIS and the ICD-9 lexicons from the National Trauma Data Bank. Five injury severity measures (ISS, maximum AIS score, New Injury Severity Score [NISS], ICD-9–Based Injury Severity Score [ICISS], TMPM) were computed using either the AIS or ICD-9 codes. These measures were compared for discrimination (area under the receiver operating characteristic curve), an estimate of proximity to a model that perfectly predicts the outcome (Akaike information criterion), and model calibration curves. RESULTS TMPM demonstrated superior receiver operating characteristic curve, Akaike information criterion, and calibration using either the AIS or ICD-9 lexicons. Calibration plots demonstrate the monotonic characteristics of the TMPM models contrasted by the nonmonotonic features of the other prediction models. CONCLUSION Severity measures were more accurate with the AIS lexicon rather than ICD-9. NISS proved superior to ISS in either lexicon. Since NISS is simpler to compute, it should replace ISS when a quick estimate of injury severity is required for AIS-coded injuries. Calibration curves suggest that the nonmonotonic nature of ISS may undermine its performance. TMPM demonstrated superior overall mortality prediction compared with all other models including ISS whether the AIS or ICD-9 lexicons were used. Because TMPM provides an absolute probability of death, it may allow clinicians to communicate more precisely with one another and with patients and families. LEVEL OF EVIDENCE Disagnostic study, level I; prognostic study, level II.
Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes

Short-term cultures of human peripheral blood monocytes were shown to synthesize the alternative pathway complement components C3, factors B (B) and D (D), and properdin, the regulatory proteins C3b inactivator (C3bINA) and beta 1H, in addition to C2, C4, and C5. B, D, properdin, C3bINA, and C2 were detected by functional assays, whereas beta 1H, C4, C3, and C5 could only be detected using immunochemical procedures. Immunoperoxidase localization studies showed that all the cells in each culture contained each component, so it is possible that all monocytes synthesize each component. It is concluded that cells of the monocyte- macrophage series form a mobile source of complement components and regulatory proteins which can be concentrated at sites of inflammation.
Melanopsin-expressing retinal ganglion cells are more injury-resistant in a chronic ocular hypertension model.

PURPOSE To investigate the survival of melanopsin-expressing retinal ganglion cells (mRGCs) after the induction of chronic ocular hypertension. METHODS Intraocular pressure (IOP) was elevated in adult Sprague-Dawley rats using an argon laser to photocoagulate the episcleral and limbal veins. IOP was measured with a calibrated tonometer and monitored for a period. Seven days before the animals were killed, a piece of sterile foam soaked with gold fluorescent dye was placed onto the superior colliculus (SC) to label the SC-projecting retinal ganglion cells (scRGCs) retrogradely. mRGCs were visualized by free floating immunohistochemistry on whole-mounted retinas. The number of surviving scRGCs and mRGCs were counted on flatmounted retinas. The branching pattern of dendrites and soma size of mRGCs were examined. RESULTS An approximately 1.7-fold increase of IOP and a significant loss of scRGCs were found in experimental eyes after laser photocoagulation. However, no significant cell loss or morphologic changes on mRGCs and their dendrites after the induction of chronic ocular hypertension are noticed over a 12-week period. CONCLUSIONS Although the degeneration of retinal ganglion cells (RGCs) is a major concern in glaucomatous damage, the findings show that mRGCs are less susceptible to death after the induction of chronic ocular hypertension. This result indicates that mRGCs carry some unique properties that are different from those of other subpopulations of RGCs. The immunohistochemistry approach can be used to distinguish easily these mRGCs from other subtypes. This method provides a useful tool to investigate their injury-resistant properties that are informative for the development of effective neuroprotective treatment for glaucoma.
Permeability Evolution and Frictional Stability of Fabricated Fractures With Specified Roughness

Roughness is widely observed on natural fractures, and its impact on the potential for induced seismicity and associated fluid migration in the subsurface remains unclear. Here we perform fracture shearing and fluid flow experiments on artificially fabricated fractures with specified roughness to investigate the role of fracture roughness on frictional properties and permeability evolution. Given the experimental conditions, we observe that rough fractures show high roughness ratio Sq/Lw and return higher frictional strength due to the presence of cohesive interlocking asperities. Rough fracture surfaces show velocity strengthening behavior in the initial shearing stage, which may evolve to velocity neutral and velocity weakening at greater displacements—suggesting a dynamic weakening that rough fractures become less stable with shearing. The surface roughness exerts a dominant control on permeability evolution over the entire shearing history. Permeability declines monotonically by about 2 orders of magnitude for smooth fractures. For high roughness fractures, the permeabilities evolve episodically due to cycled compaction and dilation during shearing. With a slip distance of 6 to 8 mm, permeability of the rough surface may enhance up to an order of magnitude, but significant permeability reduction may also occur for rough samples when asperities are highly worn with gouge clogging flow paths. However, there is no obvious correlation between permeability evolution and frictional behavior for rough fracture samples when fractures are subject to sudden sliding velocity changes.
A survey of mothers' knowledge about childhood diarrhoea and its management among a marginalised community of Morang, Nepal.

BACKGROUND Diarrhoea, a common disease, is one of the major determinants of childhood morbidity and mortality in Nepal. METHOD This cross-sectional survey used a self-designed and pretested structured questionnaire to gather data on mothers' knowledge about childhood diarrhoea. The study was conducted in the Morang district of Nepal from June to August 2010. Data was analysed using descriptive and inferential statistics. Testing for significant difference and correlation of mothers' knowledge about diarrhoea with demographic factors were performed by using Kruskal-Wallis test and Spearman's rank correlation at an alpha level of 0.05. RESULTS Mothers had some basic knowledge about the prevention of diarrhoea, and fluids/foods which can or cannot be given during bouts of diarrhoea. Knowledge about signs of dehydration was poor. None of the mothers were able to mention all the steps for correct and complete preparation of oral rehydration salt (ORS) and salt-sugar-water (SSW) solutions. Only 8.5% of the mothers stated that the purpose of giving ORS solution during diarrhoea is to prevent the child from getting dehydrated. CONCLUSION Knowledge about signs of dehydration and the management approaches of diarrhoea at home was poor. Thus, there is a need for public health educational interventions.
Entrepreneurial Perceptions and Knowledge among Graduates of Nigerian Universities

Perceived desirability and feasibility have increased through participation in entrepreneurship education programmes in Universities. Thus, this study assessed entrepreneurial perceptions and knowledge among graduates of Nigerian Universities. Data were collected using questionnaire and analysed with respect to the 8 research questions using both unvariate and bivariate analyses. It was found that entrepreneurial perceptions and knowledge varied across age groups, gender, courses studied and ethnic groups among the graduates. The study reveals that: graduates aged 29-31 years had the best entrepreneurial knowledge and showed the best interest towards entrepreneurship; graduates of Engineering/Technology and Health Science courses were the most interested in entrepreneurship, while those who studied management science courses were the best performers in entrepreneurial knowledge; male graduates were more interested in starting their own business; and graduates from the South-East made the highest scores of 76% and 70% in entrepreneurial perception and knowledge respectively. The study therefore recommends the establishment of an institution to assist the older graduates with high achievement motivation to start their own business and a reinvention of the centers for entrepreneurship development so as to enhance their capability to groom more entrepreneurial and skillful University graduates.