Miracle-dz/UniFAR-FTUs huggingface dataset:
E7(7) formulation of N=2 backgrounds

In this paper we reformulate N=2 supergravity backgrounds arising in type II string theory in terms of quantities transforming under the U-duality group E7(7). In particular we combine the Ramond--Ramond scalar degrees of freedom together with the O(6,6) pure spinors which govern the Neveu-Schwarz sector by considering an extended version of generalised geometry. We give E7(7)-invariant expressions for the Kahler and hyperkahler potentials describing the moduli space of vector and hypermultiplets, demonstrating that both correspond to standard E7(7) coset spaces. We also find E7(7) expressions for the Killing prepotentials defining the scalar potential, and discuss the equations governing N=1 vacua in this formalism.
Throughput-Delay Scaling for Two Mobile Overlaid Networks

In this paper, we study the throughput and delay scaling laws of two coexisting mobile networks. By considering that both the primary and secondary networks are mobile and move according to random walk model, we propose a multi-hop transmission scheme. Based on the assumption that the secondary node can help to relay the primary packet, we show that the secondary network can achieve the same throughput and delay scaling laws as in stand-alone network D_s(m)=Θ(mλ_s(m)). Furthermore, for primary network, it is shown that the throughput-delay tradeoff scaling law is given by D_p(n)=Θ(√{n\log{n}}λ_p(n)), when the primary node is chosen as relay node. If the relay node is a secondary node, the scaling law is D_p(n)=Θ(√{n^{β}\log{n}}λ_p(n)), where β>1. The novelties of this paper lie in: i) Detailed study of the delay scaling law of the secondary network in the complex scenario where both the primary and secondary networks are mobile; ii) The impact of buffer delay on the primary and secondary networks due to the presence of preservation region. We explicitly analyze the buffer delay and obtain an expression as D^{II}_{S_R}(m)=Θ(1/√{n^{β-1}a_s(m)}).
Light and gravity signals synergize in modulating plant development

Tropisms are growth-mediated plant movements that help plants to respond to changes in environmental stimuli. The availability of water and light, as well as the presence of a constant gravity vector, are all environmental stimuli that plants sense and respond to via directed growth movements (tropisms). The plant response to gravity (gravitropism) and the response to unidirectional light (phototropism) have long been shown to be interconnected growth phenomena. Here, we discuss the similarities in these two processes, as well as the known molecular mechanisms behind the tropistic responses. We also highlight research done in a microgravity environment in order to decouple two tropisms through experiments carried out in the absence of a significant unilateral gravity vector. In addition, alteration of gravity, especially the microgravity environment, and light irradiation produce important effects on meristematic cells, the undifferentiated, highly proliferating, totipotent cells which sustain plant development. Microgravity produces the disruption of meristematic competence, i.e., the decoupling of cell proliferation and cell growth, affecting the regulation of the cell cycle and ribosome biogenesis. Light irradiation, especially red light, mediated by phytochromes, has an activating effect on these processes. Phytohormones, particularly auxin, also are key mediators in these alterations. Upcoming experiments on the International Space Station will clarify some of the mechanisms and molecular players of the plant responses to these environmental signals involved in tropisms and the cell cycle.
Feasibility and Acceptability of Global Positioning System (GPS) Methods to Study the Spatial Contexts of Substance Use and Sexual Risk Behaviors among Young Men Who Have Sex with Men in New York City: A P18 Cohort Sub-Study

Background No global positioning system (GPS) technology study has been conducted among a sample of young gay, bisexual, and other men who have sex with men (YMSM). As such, the purpose of this study was to evaluate the feasibility and acceptability of using GPS methods to understand the spatial context of substance use and sexual risk behaviors among a sample of YMSM in New York City, a high-risk population. Methods Data came from a subsample of the ongoing P18 Cohort Study (n = 75). GPS feasibility and acceptability among participants was measured with: 1) a pre- and post-survey and 2) adherence to the GPS protocol which included returning the GPS device, self-report of charging and carrying the GPS device as well as objective data analyzed from the GPS devices. Analyses of the feasibility surveys were treated as repeated measures as each participant had a pre- and post-feasibility survey. When comparing the similar GPS survey items asked at baseline and at follow-up, we present percentages and associated p-values based on chi-square statistics. Results Participants reported high ratings of pre-GPS acceptability, ease of use, and low levels of wear-related concerns in addition to few concerns related to safety, loss, or appearance, which were maintained after baseline GPS feasibility data collection. The GPS return rate was 100%. Most participants charged and carried the GPS device on most days. Of the total of 75 participants with GPS data, 75 (100%) have at least one hour of GPS data for one day and 63 (84%) had at least one hour on all 7 days. Conclusions Results from this pilot study demonstrate that utilizing GPS methods among YMSM is feasible and acceptable. GPS devices may be used in spatial epidemiology research in YMSM populations to understand place-based determinants of health such as substance use and sexual risk behaviors.
Genetic Diversity and Positive Selection Analysis of Classical Swine Fever Virus Envelope Protein Gene E2 in East China under C-Strain Vaccination

Classical swine fever virus (CSFV) causes an economically important and highly contagious disease of pigs worldwide. C-strain vaccination is one of the most effective ways to contain this disease. Since 2014, sporadic CSF outbreaks have been occurring in some C-strain vaccinated provinces of China. To decipher the disease etiology, 25 CSFV E2 genes from 169 clinical samples were cloned and sequenced. Phylogenetic analyses revealed that all 25 isolates belonged to subgenotype 2.1. Twenty-three of the 25 isolates were clustered in a newly defined subgenotype, 2.1d, and shared some consistent molecular characteristics. To determine whether the complete E2 gene was under positive selection pressure, we used a site-by-site analysis to identify specific codons that underwent evolutionary selection, and seven positively selected codons were found. Three positively selected sites (amino acids 17, 34, and 72) were identified in antigenicity-relevant domains B/C of the amino-terminal half of the E2 protein. In addition, another positively selected site (amino acid 200) exhibited a polarity change from hydrophilic to hydrophobic, which may change the antigenicity and virulence of CSFV. The results indicate that the circulating CSFV strains in Shandong province were mostly clustered in subgenotype 2.1d. Moreover, the identification of these positively selected sites could help to reveal molecular determinants of virulence or pathogenesis, and to clarify the driving force of CSFV evolution in East China.
Influence of pitting on the fatigue life of a turbine blade steel

The role of pits as stress raisers and their influence on fatigue life has been investigated for a 12Cr turbine blade material. A particular feature of this work was the establishment of an electrochemical procedure for generating pits with ‘controlled’ pit depth and low density. Pits grown under laboratory conditions were partially spherical in shape and simulated, in general appearance, those observed in service. In terms of the threshold stress intensity factor, the results supported the concept of pits acting as effective cracks of the same depth, provided that a short crack model based on an effective crack length is used.
Leishmania pifanoi Proteoglycolipid Complex P8 Induces Macrophage Cytokine Production through Toll-Like Receptor 4

ABSTRACT The P8 proteoglycolipid complex (P8 PGLC) is a glyconjugate expressed by Leishmania mexicana complex parasites. We previously have shown that vaccination with P8 PGLC provides protection against cutaneous leishmaniasis in susceptible BALB/c mice. However, the biological importance of this complex remains unknown. Here we show that P8 PGLC localizes to the surface of Leishmania pifanoi amastigotes and that upon exposure to macrophages, P8 PGLC binds and induces inflammatory cytokine and chemokine mRNAs such as tumor necrosis factor alpha and RANTES early after stimulation. Our studies indicate that cytokine and chemokine induction is dependent upon Toll-like receptor 4 (TLR4). Interestingly, key inflammatory cytokines and chemokines (such as interleukin-6 [IL-6], macrophage inflammatory protein 1β, and beta interferon [IFN-β]) that can be induced through TLR4 activation were not induced or only slightly upregulated by P8 PGLC. Activation by P8 PGLC does not occur in the presence of TLR4 alone and requires both CD14 and myeloid differentiation protein 2 for signaling; this requirement may be responsible for the limited TLR4 response. This is the first characterization of a TLR4 ligand for Leishmania. In vitro experiments indicate that L. pifanoi amastigotes induce lower levels of cytokines in macrophages in the absence of TLR4; however, notably higher IL-10/IFN-γ ratios were found for TLR4-deficient mice than for BALB/c mice. Further, increased levels of parasites persist in BALB/c mice deficient in TLR4. Taken together, these results suggest that TLR4 recognition of Leishmania pifanoi amastigotes is important for the control of infection and that this is mediated, in part, through the P8 PGLC.
MAP Detection and Robust Lossy Coding Over Soft-Decision Correlated Fading Channels

The joint source-channel coding (JSCC) problem for soft-decision-demodulated time-correlated fading channels is investigated without the use of channel coding and interleaving. For the purpose of system design, the recently introduced nonbinary noise discrete channel with queue-based (QB) noise (NBNDC-QB) is adopted. This analytically tractable Markovian model has been shown to represent effectively correlated fading channels that are hard to handle analytically. Optimal sequence maximum a posteriori (MAP) detection of a discrete Markov source sent over the NBNDC-QB is first studied. When the Markov source is binary and symmetric, a necessary and sufficient condition under which the MAP decoder is reduced to a simple instantaneous symbol-by-symbol decoder is established. Two robust lossy source coding schemes with a low encoding delay are next proposed for the NBNDC-QB. The first scheme consists of a scalar quantizer (SQ), a proper index assignment, and a sequence MAP decoder designed to harness the redundancy left in the indexes of the quantizer and the soft-decision output and the noise correlation of the channel. The second scheme is a classical noise-resilient vector quantizer known as the channel-optimized vector quantizer (COVQ). It is demonstrated that both systems can successfully exploit the memory and soft-decision information of the channel. Signal-to-distortion-ratio (SDR) gains of more than 1.7 dB are obtained over hard-decision demodulation by using only two bits for soft decision. Furthermore, gains as high as 4.4 dB can be achieved for a strongly correlated channel, in comparison with systems designed for the ideally interleaved (memoryless) channel. Finally, it is numerically observed that, for low coding rates, the NBNDC-QB model can accurately approximate discrete fading channels (DFCs) in terms of SDR performance.
The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma

In addition to Breslow depth, the authors previously described how increasing mitotic rate and decreasing age predicted sentinel lymph node (SLN) metastases in patients with melanoma. The objectives of the current study were to verify those previous results and to create a prediction model for the better selection of which patients with melanoma should undergo SLN biopsy.
Functional Anatomy of Visuomotor Skill Learning in Human Subjects Examined with Positron Emission Tomography

The present study was designed to examine patterns of regional cerebral blood flow (CBF) associated with the learning of a repeated visuomotor sequence both in the early and late phases of the acquisition process. In addition, changes in blood flow related to the implicit versus explicit aspects of learning such a skill were investigated. Fourteen normal control subjects were scanned while performing the task (i) in both early and advanced learning stages of the visuomotor sequence; (ii) after having acquired explicit knowledge of the sequences; and (iii) in two control conditions (perceptual and random sequence). Subtraction of the random condition from the highly learned condition revealed specific areas of activity in the right ventral striatum and dentate nucleus of the cerebellum. Blood flow changes in the right hemisphere were also seen in the medial posterior parietal and prestriate regions, as well as in the anterior cingulate cortex. Finally, once the subjects had acquired explicit knowledge of the embedded sequence that was presented in the highly learned condition, increased CBF activity was observed only in the mid‐ventrolateral frontal area in the right hemisphere. These findings confirm that both the striatum and the cerebellum are involved in the implicit acquisition of a visuomotor skill, especially in the advanced stages of the learning process, and furthermore that the ventrolateral prefrontal cortex contributes preferentially to the declarative aspect of this task.
Utilization and Outcomes of Mental Health Services Among Patients in Drug Treatment

Abstract This study examined utilization of mental health services and treatment outcomes among 1,091 patients with mental health problems recruited from 39 treatment programs in 13 California counties. We compared three groups: one that received dual treatment from drug and mental health programs (N = 294), one that received mental health services only within drug treatment programs (N = 578), and one that received no mental health services (N = 219). Individuals who received dual treatment had more severe substance use and mental health problems, followed in severity by those who received mental health services within drug treatment, and those who received no services. All groups significantly reduced their psychiatric severity at the follow-up, although there were no group differences in treatment retention and drug use outcomes. These findings suggest that individuals with mental health problems can be successfully treated within drug treatment programs and/or in conjunction with mental health providers.
Evolution of stresses in passivated and unpassivated metal interconnects

This paper discusses computational simulations of the evolution of stresses and deformation in unpassivated and SiO_2-passivated Al lines on Si substrates. The finite element model accounts for elastic-plastic deformation in the Al lines during etching, passivation, and subsequent thermal cycling, by recourse to a generalized plane strain formulation within the context of a unit cell with appropriately constrained boundary conditions. The effects of different controlled variations in thermal history, and in the width, height, spacing, and yield behavior of the Al lines are analyzed; all these factors are seen to have potentially strong effects on the evolution of stresses within the lines. The predictions of the computations presented in this work are amenable for direct comparisons with experiments of curvature evolution along and perpendicular to the lines upon patterning, passivation, and thermal loading. The predicted stresses in metal interconnects can be directly used for reliability modeling purposes.
The 4C5 Cell-Impermeable Anti-HSP90 Antibody with Anti-Cancer Activity, Is Composed of a Single Light Chain Dimer

MAb 4C5 is a cell impermeable, anti-HSP90 murine monoclonal antibody, originally produced using hybridoma technology. We have previously shown that mAb 4C5 specifically recognizes both the α- and to a lesser extent the β-isoform of HSP90. Additionally, in vitro and in vivo studies revealed that by selectively inhibiting the function of cell-surface HSP90, mAb 4C5 significantly impairs cancer cell invasion and metastasis. Here we describe the reconstitution of mAb 4C5 into a mouse-human chimera. More importantly we report that mAb 4C5 and consequently its chimeric counterpart are completely devoid of heavy chain and consist only of a functional kappa light chain dimer. The chimeric antibody is shown to retain the original antibody's specificity and functional properties. Thus it is capable of inhibiting the function of surface HSP90, leading to reduced cancer cell invasion in vitro. Finally, we present in vivo evidence showing that the chimeric 4C5 significantly inhibits the metastatic deposit formation of MDA-MB-453 cells into the lungs of SCID mice. These data suggest that a chimeric kappa light chain antibody could be potentially used as an anti-cancer agent, thereby introducing a novel type of antibody fragment, with reduced possible adverse immunogenic effects, into cancer therapeutics.
Massively Parallel Radiosity in thePresence of Multiple Isotropic Volume

We present a massively parallel algorithm for computing radiosity in a scene containing an isotropic scattering medium of high albedo. The algorithm is based on a new formalism: a coordinate evolution on the set of light rays in the scene. The evolution reparameterizes rays from their points of origin to their points of termination. Local coordinate systems on the set of light rays are distributed over a two-dimensional lattice of parallel processors, and transformations between coordinate systems are computed using only local communication between processors. The algorithm is implemented on a MasPar-1 which is a SIMD computer having over 2000 processors.
Prevalence of enteric parasites in pet macaques in Sulawesi, Indonesia

On the Indonesian island of Sulawesi, nonhuman primate pets come into frequent contact with humans, presenting the possibility of zoonotic and anthropozoonotic disease transmission. We collected fecal samples from 88 pet macaques representing six of the seven macaque species currently recognized as endemic to Sulawesi (Macaca nigra, M. nigrescens, M. hecki, M. tonkeana, M. maura, and M. ochreata) as well as two non‐endemic species (M. fascicularis and M. nemestrina) in order to determine the prevalence of intestinal parasitic infection in this population. Seven taxa of intestinal protozoa (Blastocystis hominis, Iodamoeba bütschlii, Entamoeba coli, Entamoeba hartmanni, Chilomastrix mesnili, Endolimax nana, and Retortamonas intestinalis) and three taxa of nematodes (hookworm, Trichuris spp., and Ascaris spp.) were detected. The overall parasitization rate was 59.1%. Commensal organisms predominated in this population. Parasitization was not statistically correlated with macaque age group, sex, species, or location, or with the owner's level of education. These findings are discussed in the context of primate pet ownership practices in Sulawesi. Am. J. Primatol. 62:71‐82, 2004. © 2004 Wiley‐Liss, Inc.
Tonotopy in human auditory cortex examined with functional magnetic resonance imaging

Tonotopic organization within the human auditory cortex was investigated with functional magnetic resonance imaging (fMRI) using the blood oxygenation level‐dependent (BOLD) contrast mechanism. Single‐frequency pulsed tones were alternated with no‐tone conditions to elicit stimulus‐specific functional activity. Differential frequency‐specific activity was imaged within the auditory cortex Activations for high‐frequency tones were located more posteriorly and medially than those for low‐frequency tones. Such a pattern is consistent with descriptions of tonotopic organization suggested by other nonneuroimaging methodologies used with human and nonhuman primates. Furthermore, these results demonstrate that fMRI can be used to reliably investigate functional organization of the human auditory cortex. Hum. Brain Mapping 4:18–25, 1997. © 1997 Wiley‐Liss, Inc.
Stent Fracture, Valve Dysfunction, and Right Ventricular Outflow Tract Reintervention After Transcatheter Pulmonary Valve Implantation: Patient-Related and Procedural Risk Factors in the US Melody Valve Trial

Background— Among patients undergoing transcatheter pulmonary valve (TPV) replacement with the Melody valve, risk factors for Melody stent fracture (MSF) and right ventricular outflow tract (RVOT) reintervention have not been well defined. Methods and Results— From January 2007 to January 2010, 150 patients (median age, 19 years) underwent TPV implantation in the Melody valve Investigational Device Exemption trial. Existing conduit stents from a prior catheterization were present in 37 patients (25%, fractured in 12); 1 or more new prestents were placed at the TPV implant catheterization in 51 patients. During follow-up (median, 30 months), MSF was diagnosed in 39 patients. Freedom from a diagnosis of MSF was 77±4% at 14 months (after the 1-year evaluation window) and 60±9% at 39 months (3-year window). On multivariable analysis, implant within an existing stent, new prestent, or bioprosthetic valve (combined variable) was associated with longer freedom from MSF (P<0.001), whereas TPV compression (P=0.01) and apposition to the anterior chest wall (P=0.02) were associated with shorter freedom from MSF. Freedom from RVOT reintervention was 86±4% at 27 months. Among patients with a MSF, freedom from RVOT reintervention after MSF diagnosis was 49±10% at 2 years. Factors associated with reintervention were similar to those for MSF. Conclusions— MSF was common after TPV implant in this multicenter experience and was more likely in patients with severely obstructed RVOT conduits and when the TPV was directly behind the anterior chest wall and/or clearly compressed. A TPV implant site protected by a prestent or bioprosthetic valve was associated with lower risk of MSF and reintervention. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT00740870.