Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimizing Language Augmentation for Multilingual Large Language Models: A Case Study on Korean

Large language models (LLMs) use pretraining to predict the subsequent word; however, their expansion requires significant computing resources. Numerous big tech companies and research institutes have developed multilingual LLMs (MLLMs) to meet current demands, overlooking less-resourced languages (LRLs). This study proposed three strategies to enhance the performance of LRLs based on the publicly available MLLMs. First, the MLLM vocabularies of LRLs were expanded to enhance expressiveness. Second, bilingual data were used for pretraining to align the high- and less-resourced languages. Third, a high-quality small-scale instruction dataset was constructed and instruction-tuning was performed to augment the LRL. The experiments employed the Llama2 model and Korean was used as the LRL, which was quantitatively evaluated against other developed LLMs across eight tasks. Furthermore, a qualitative assessment was performed based on human evaluation and GPT4. Experimental results showed that our proposed Bllossom model exhibited superior performance in qualitative analyses compared to previously proposed Korean monolingual models.
Morbid Obesity and Tracheal Intubation

The tracheas of obese patients may be more difficult to intubate than those of normal-weight patients. We studied 100 morbidly obese patients (body mass index >40 kg/m2) to identify which factors complicate direct laryngoscopy and tracheal intubation. Preoperative measurements (height, weight, neck circumference, width of mouth opening, sternomental distance, and thyromental distance) and Mallampati score were recorded. The view during direct laryngoscopy was graded, and the number of attempts at tracheal intubation was recorded. Neither absolute obesity nor body mass index was associated with intubation difficulties. Large neck circumference and high Mallampati score were the only predictors of potential intubation problems. Because in all but one patient the trachea was intubated successfully by direct laryngoscopy, the neck circumference that requires an intervention such as fiberoptic bronchoscopy to establish an airway remains unknown. We conclude that obesity alone is not predictive of tracheal intubation difficulties.
Advanced Propagation Model (APM) Analysis of VHF Signals in the Southern California Desert

Abstract : This report analyzes very high frequency signal strength data from two Naval Oceanic & Atmospheric Administration weather radio transmitters located in southern California and southwestern Arizona over a wide range of topography ranging from relatively flat to mountainous terrain. Meteorological information was obtained from local radiosonde measurement stations at Miramar (NKX) and Yuma Proving Ground (1Y7). These data are used as the basis for a validation study of the Advanced Propagation Model (APM) to determine its applicability for low-altitude mobile radio communications applications over terrain. The APM performs very well for low-altitude propagation over terrain and at least as well as the widely used diffraction model, Terrain Integrated Rough Earth Model (TIREM), under standard conditions. The APM performs better when variable refractivity data are available.
Effects of Angiotensin-Converting Enzyme Inhibition on the Development of the Atrial Fibrillation Substrate in Dogs With Ventricular Tachypacing–Induced Congestive Heart Failure

Background—Atrial structural remodeling creates a substrate for atrial fibrillation (AF), but the underlying signal transduction mechanisms are unknown. This study assessed the effects of ACE inhibition on arrhythmogenic atrial remodeling and associated mitogen-activated protein kinase (MAPK) changes in a dog model of congestive heart failure (CHF). Methods and Results—Dogs were subjected to various durations of ventricular tachypacing (VTP, 220 to 240 bpm) in the presence or absence of oral enalapril 2 mg · kg−1 · d−1. VTP for 5 weeks induced CHF, local atrial conduction slowing, and interstitial fibrosis and prolonged atrial burst pacing–induced AF. Atrial angiotensin II concentrations and MAPK expression were increased by tachypacing, with substantial changes in phosphorylated forms of c-Jun N-terminal kinase (JNK), extracellular signal–regulated kinase (ERK), and p38-kinase. Enalapril significantly reduced tachypacing-induced changes in atrial angiotensin II concentrations and ERK expression. Enalapril also attenuated the effects of CHF on atrial conduction (conduction heterogeneity index reduced from 3.1±0.4 to 1.9±0.2 ms/mm, P <0.05), atrial fibrosis (from 11.9±1.1% to 7.5±0.4%, P <0.01), and mean AF duration (from 651±164 to 218±75 seconds, P <0.05). Vasodilator therapy of a separate group of VTP dogs with hydralazine and isosorbide mononitrate did not alter CHF-induced fibrosis or AF promotion. Conclusions—CHF-induced increases in angiotensin II content and MAPK activation contribute to arrhythmogenic atrial structural remodeling. ACE inhibition interferes with signal transduction leading to the AF substrate in CHF and may represent a useful new component to AF therapy.
Discriminative figure-centric models for joint action localization and recognition

In this paper we develop an algorithm for action recognition and localization in videos. The algorithm uses a figure-centric visual word representation. Different from previous approaches it does not require reliable human detection and tracking as input. Instead, the person location is treated as a latent variable that is inferred simultaneously with action recognition. A spatial model for an action is learned in a discriminative fashion under a figure-centric representation. Temporal smoothness over video sequences is also enforced. We present results on the UCF-Sports dataset, verifying the effectiveness of our model in situations where detection and tracking of individuals is challenging.
Pore size matters for potassium channel conductance

Ion channels are membrane proteins that mediate efficient ion transport across the hydrophobic core of cell membranes, an unlikely process in their absence. K+ channels discriminate K+ over cations with similar radii with extraordinary selectivity and display a wide diversity of ion transport rates, covering differences of two orders of magnitude in unitary conductance. The pore domains of large- and small-conductance K+ channels share a general architectural design comprising a conserved narrow selectivity filter, which forms intimate interactions with permeant ions, flanked by two wider vestibules toward the internal and external openings. In large-conductance K+ channels, the inner vestibule is wide, whereas in small-conductance channels it is narrow. Here we raise the idea that the physical dimensions of the hydrophobic internal vestibule limit ion transport in K+ channels, accounting for their diversity in unitary conductance.
Simulation of Land Reclamation's Effect on the Water Exchange in Tianjin Coastal Area

The effect of land reclamation on the water exchange of Tianjin coastal area in Bohai Bay was studied using an integrated hydrodynamic-dispersion numerical model. Based on the marine function regionalization, the whole Tianjin coastal area was divided into eleven sub-areas. The water exchange between each sub-area was calculated according to the numerical results and a matrix was introduced to represent the water exchange amongst the sub-areas. In particular, the effect of land reclamation on the water exchange in the two primary zones for sewage discharging was evaluated. Results show that: 1) The water exchange of southern Tianjin coastal area becomes weaker while the middle part of it becomes stronger due to the land reclamation. 2) Land reclamation makes the transport path of outlet sewage shifted.
A language model combining n-grams and stochastic finite state automata

This paper describes a new kind of language models composed of several local models and a general model linking the local models together. Local models describe more (cid:12)nely subparts of the textual data than a conventional n-gram trained on the complete corpus. They are built on lexical and syntactic criteria. Both local and global models are integrated in a single hidden Markov model. Experiments showed a 14% decrease in perplexity compared to a bigram model on a small corpus of telephonic communications
Exploiting WEE1 kinase activity as FUS::DDIT3-dependent therapeutic vulnerability in myxoid liposarcoma

The pathognomonic FUS::DDIT3 fusion protein drives myxoid liposarcoma (MLS) tumorigenesis via aberrant transcriptional activation of oncogenic signaling. Since FUS::DDIT3 has so far not been pharmacologically tractable to selectively target MLS cells, this study investigated the functional role of the cell cycle regulator WEE1 as novel FUS::DDIT3-dependent therapeutic vulnerability in MLS. Here we demonstrate that enhanced WEE1 pathway activity represents a hallmark of FUS::DDIT3-expressing cell lines as well as MLS tissue specimens and that WEE1 is required for MLS cellular survival in vitro and in vivo. Pharmacologic inhibition of WEE1 activity results in DNA damage accumulation and cell cycle progression forcing cells to undergo apoptotic cell death. In addition, our results uncover FUS::DDIT3-dependent WEE1 expression as an oncogenic survival mechanism to tolerate high proliferation and resulting replication stress in MLS. Fusion protein-driven G1/S cell cycle checkpoint deregulation via overactive Cyclin E/CDK2 complexes thereby contributes to enhanced WEE1 inhibitor sensitivity in MLS. These findings identify WEE1-mediated replication stress tolerance as molecular vulnerability in FUS::DDIT3-driven MLS tumorigenesis that could represent a novel target for therapeutic intervention.
Behavioral / Cognitive Body Posture Modulates Action Perception

Recent studies have highlighted cognitive and neural similarities between planning and perceiving actions. Given that action planning involves a simulation of potential action plans that depends on the actor’s body posture, we reasoned that perceiving actions may also be influenced by one’s body posture. Here, we test whether and how this influence occurs by measuring behavioral and cerebral (fMRI) responses in human participants predicting goals of observed actions, while manipulating postural congruency between their own body posture and postures of the observed agents. Behaviorally, predicting action goals is facilitated when the body posture of the observer matches the posture achieved by the observed agent at the end of his action (action’s goal posture). Cerebrally, this perceptual postural congruency effect modulates activity in a portion of the left intraparietal sulcus that has previously been shown to be involved in updating neural representations of one’s own limb posture during action planning. This intraparietal area showed stronger responses when the goal posture of the observed action did not match the current body posture of the observer. These results add two novel elements to the notion that perceiving actions relies on the same predictive mechanism as planning actions. First, the predictions implemented by this mechanism are based on the current physical configuration of the body. Second, during both action planning and action observation, these predictions pertain to the goal state of the action.
Establishing Functional Classes In A Chimpanzee (Pan troglodytes) With A Two-item Sequential-Responding Procedure.

A 9-year-old female chimpanzee was trained on a two-item sequential-responding task. Attempts were made with successive-reversal training to establish functional classes. In Experiment 1, the subject was exposed to between-session successive-reversal training in which one of two pairs of stimuli was reversed, and transfer of reversal responding to the other pair was tested with nonreinforcement probe trials. She did not show transfer during the course of reversals. Stimulus control established in the original training was maintained on nonreinforcement probe trials. In Experiment 2, within-session reversals were introduced. She showed transfer from the initially reversed pair to the other. The results were consistent with Vaughan's (1988) results with pigeons on successive discriminations, which indicated the formation of functional classes. In Experiment 3, crossover and wild-card tests were conducted to clarify the stimulus control of sequential responding. The results suggested that the sequential responding was controlled only by the first stimulus of each pair. To establish control by both first and second stimuli, trial-unique stimuli or wild cards were substituted for one of the items of the lists in Experiment 4. Further transfer tests, in which stimuli for the two new pairs appeared, were also given to the subject. She successfully responded to these two merged lists and reversed the order as the result of reversal training.
Characterization and evaluation of antimicrobial and cytotoxic effects of Streptomyces sp. HUST012 isolated from medicinal plant Dracaena cochinchinensis Lour.

A highly potent secondary metabolite producing endophytic strain, Streptomyces sp. HUST012 was isolated from the stems of the medicinal plant Dracaena cochinchinensis Lour. Strain HUST012 showed antimicrobial and antitumor activities which were significantly much higher than those of dragon's blood extracted from D. cochinchinensis Lour. On further analysis, the strain was found to produce two metabolites, SPE-B11.8 (elucidated to be a novel metabolite (Z)-tridec-7-ene-1,2,13-tricarboxylic acid) and SPE-B5.4 (elucidated as Actinomycin-D). The Minimum Inhibitory Concentration values of SPE-B11.8 against a set of test bacterial organisms (Methicillin-resistant Staphylococcus epidermis ATCC 35984, Methicillin-resistant Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Klebsiella pneumoniae ATCC 13883) ranged between 15.63 and 62.5 μg/ml while that for SPE-B5.4 ranged between 0.04 and 2.24 μg/ml. The compound SPE-B11.8 showed cytotoxic effect at 41.63 and 29.54 μg/ml IC50-values against Hep G2 and MCF-7, respectively, while the compound SPE-B5.4 exhibited stronger activities against them at 0.23 and 0.18 μg/ml IC50-values.
An unscheduled switch to endocycles induces a reversible senescent arrest that impairs growth of the Drosophila wing disc

A programmed developmental switch to G / S endocycles results in tissue growth through an increase in cell size. Unscheduled, induced endocycling cells (iECs) promote wound healing but also contribute to cancer. Much remains unknown, however, about how these iECs affect tissue growth. Using the D. melanogaster wing disc as model, we find that populations of iECs initially increase in size but then subsequently undergo a heterogenous arrest that causes severe tissue undergrowth. iECs acquired DNA damage and activated a Jun N-terminal kinase (JNK) pathway, but, unlike other stressed cells, were apoptosis-resistant and not eliminated from the epithelium. Instead, iECs entered a JNK-dependent and reversible senescent-like arrest. Senescent iECs promoted division of diploid neighbors, but this compensatory proliferation did not rescue tissue growth. Our study has uncovered unique attributes of iECs and their effects on tissue growth that have important implications for understanding their roles in wound healing and cancer.
Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus

A key to motor control is the motor thalamus, where several inputs converge. One excitatory input originates from layer 5 of primary motor cortex (M1L5), while another arises from the deep cerebellar nuclei (Cb). M1L5 terminals distribute throughout the motor thalamus and overlap with GABAergic inputs from the basal ganglia output nuclei, the internal segment of the globus pallidus (GPi) and substantia nigra pars reticulata (SNr). In contrast, it is thought that Cb and basal ganglia inputs are segregated. Therefore, we hypothesized that one potential function of the GABAergic inputs from basal ganglia is to selectively inhibit, or gate, excitatory signals from M1L5 in the motor thalamus. Here, we tested this possibility and determined the circuit organization of mouse (both sexes) motor thalamus using an optogenetic strategy in acute slices. First, we demonstrated the presence of a feedforward transthalamic pathway from M1L5 through motor thalamus. Importantly, we discovered that GABAergic inputs from the GPi and SNr converge onto single motor thalamic cells with excitatory synapses from M1L5 and, unexpectedly, Cb as well. We interpret these results to indicate that a role of the basal ganglia is to gate the thalamic transmission of M1L5 and Cb information to cortex. Significance Statement In this study, we extend the common conception of the basal ganglia as an information loop: flowing from cortex to basal ganglia, to thalamus, and back to cortex. We used tricolor viral labeling and an optogenetic approach to reveal that projections from the output nuclei of the basal ganglia converge with inputs from both layer 5 of primary motor cortex and the deep cerebellar nuclei onto individual thalamic relay cells. Not only do these findings add nuance to the notion that cerebellar and basal ganglia circuits through motor thalamus are independent, but also highlight a novel intersection between basal ganglia and cortex that countervails long-held conceptions of how the brain handles motor commands.
Evidence That Both Ligand Binding and Covalent Adaptation Drive a Two-State Equilibrium in the Aspartate Receptor Signaling Complex

The transmembrane aspartate receptor of bacterial chemotaxis regulates an associated kinase protein in response to both attractant binding to the receptor periplasmic domain and covalent modification of four adaptation sites on the receptor cytoplasmic domain. The existence of at least 16 covalent modification states raises the question of how many stable signaling conformations exist. In the simplest case, the receptor could have just two stable conformations (“on” and “off”) yielding the two-state behavior of a toggle-switch. Alternatively, covalent modification could incrementally shift the receptor between many more than two stable conformations, thereby allowing the receptor to function as a rheostatic switch. An important distinction between these models is that the observed functional parameters of a toggle-switch receptor could strongly covary as covalent modification shifts the equilibrium between the on- and off-states, due to population-weighted averaging of the intrinsic on- and off-state parameters. By contrast, covalent modification of a rheostatic receptor would create new conformational states with completely independent parameters. To resolve the toggle-switch and rheostat models, the present study has generated all 16 homogeneous covalent modification states of the receptor adaptation sites, and has compared their effects on the attractant affinity and kinase activity of the reconstituted receptor–kinase signaling complex. This approach reveals that receptor covalent modification modulates both attractant affinity and kinase activity up to 100-fold, respectively. The regulatory effects of individual adaptation sites are not perfectly additive, indicating synergistic interactions between sites. The three adaptation sites at positions 295, 302, and 309 are more important than the site at position 491 in regulating attractant affinity and kinase activity, thereby explaining the previously observed dominance of the former three sites in in vivo studies. The most notable finding is that covalent modification of the adaptation sites alters the receptor attractant affinity and the receptor-regulated kinase activity in a highly correlated fashion, strongly supporting the toggle-switch model. Similarly, certain mutations that drive the receptor into the kinase activating state are found to have correlated effects on attractant affinity. Together these results provide strong evidence that chemotaxis receptors possess just two stable signaling conformations and that the equilibrium between these pure on- and off-states is modulated by both attractant binding and covalent adaptation. It follows that the attractant and adaptation signals drive the same conformational change between the two settings of a toggle. An approach that quantifies the fractional occupancy of the on- and off-states is illustrated.
On Computing Puiseux Series for Multiple Imaginary Characteristic Roots of LTI Systems With Commensurate Delays

Obtaining the Puiseux series of multiple imaginary (characteristic) roots (MIRs) is a fundamental issue in the stability analysis of time-delay systems. However, to the best of the authors' knowledge, this issue has not been fully investigated up to date. This note focuses on the Puiseux series expansion of MIRs of linear time-invariant systems including commensurate delays. For an MIR of any multiplicity, we propose an algorithm for defining the structure of the Puiseux series, as well as the explicit computation of the corresponding coefficients. By using the proposed method, we can find all the Puiseux series corresponding to all the root loci.
Participatory sustainability assessment for spatial planning: reflections from a pilot exercise in Flanders, Belgium

Abstract Sustainability is both an appealing and bewildering concept, subject to a range of interpretations. While this plurality of views can lead to innovative policy solutions to complex societal challenges, it can also lead to confusion and even decision paralysis. If sustainability is to guide decision-making, practical and user-friendly participatory decision-support processes are required. Sustainability assessment allows to systematically integrate sustainability considerations in decision-making. Flanders, Belgium’s northern region, has seen a recent boost of public policy initiatives for sustainability, which includes a stated interest in exploratory sustainability assessments in which the public can be included. A tailor-made approach, based on a modified nominal group technique (NGT), was developed and applied. The NGT-based exploratory sustainability assessment consisted of two rounds during which participants were asked to reflect first individually, and then collectively, about sustainability implications of spatial planning policy documents. The participants stressed the adaptability and user-friendliness of the approach, but also emphasized the difficulty to identify clear sustainability trade-offs. NGT does not allow for a full sustainability assessment on its own, but this pilot exercise shows it can be used as an exploratory sustainability assessment, which can be complemented with other methods and inputs in a later stage of decision-making. We provide a critical reflection on NGT, as a simple yet innovative method in support of participatory sustainability assessment.