Miracle-dz/UniFAR-FTUs huggingface dataset:
Reciprocal relations between parents' physical discipline and children's externalizing behavior during middle childhood and adolescence

Abstract Using data from two long-term longitudinal projects, we investigated reciprocal relations between maternal reports of physical discipline and teacher and self-ratings of child externalizing behavior, accounting for continuity in both discipline and externalizing over time. In Study 1, which followed a community sample of 562 boys and girls from age 6 to 9, high levels of physical discipline in a given year predicted high levels of externalizing behavior in the next year, and externalizing behavior in a given year predicted high levels of physical discipline in the next year. In Study 2, which followed an independent sample of 290 lower income, higher risk boys from age 10 to 15, mother-reported physical discipline in a given year predicted child ratings of antisocial behavior in the next year, but child antisocial behavior in a given year did not predict parents' use of physical discipline in the next year. In neither sample was there evidence that associations between physical discipline and child externalizing changed as the child aged, and findings were not moderated by gender, race, socioeconomic status, or the severity of the physical discipline. Implications for the reciprocal nature of the socialization process and the risks associated with physical discipline are discussed.
Combining the Antigen Processing Components TAP and Tapasin Elicits Enhanced Tumor-Free Survival

Purpose: Tpn is a member of the MHC class I loading complex and functions to bridge the TAP peptide transporter to MHC class I molecules. Metastatic human carcinomas often express low levels of the antigen-processing components Tapasin and TAP and display few functional surface MHC class I molecules. As a result, carcinomas are unrecognizable by effector CTLs. The aim of this study is to examine if Tapasin (Tpn) plays a critical role in the escape of tumors from immunologic recognition. Experimental Design: To test our hypothesis, a nonreplicating adenovirus vector encoding human Tpn (AdhTpn) was constructed to restore Tpn expression in vitro and in vivo in a murine lung carcinoma cell line (CMT.64) that is characterized by down-regulation of surface MHC class I due to deficiency in antigen-processing components. Results:Ex vivo, Tpn expression increased surface MHC class I and restored susceptibility of tumor cells to antigen-specific CTL killing, and AdhTpn infection of dendritic cells also significantly increased cross-presentation and cross-priming. Furthermore, tumor-bearing animals inoculated with AdhTpn demonstrated a significant increase in CD8+ and CD4+ T cells and CD11c+ dendritic cells infiltrating the tumors. Provocatively, whereas syngeneic mice bearing tumors that were inoculated with AdhTpn a significant reduction in tumor growth and increased survival compared with vector controls, combining AdhTpn inoculation with AdhTAP1 resulted in a significant augmentation of protection from tumor-induced death than either component alone. Conclusions: This is the first demonstration that Tpn alone can enhance survival and immunity against tumors but additionally suggests that Tpn and TAP should be used together as components of immunotherapeutic vaccine protocols to eradicate tumors.
Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of vascular endothelial growth factor receptor into a remote organ.

Antiangiogenic therapy shows promise as a strategy for cancer treatment. We constructed an adenovirus (AdVEGF-ExR) expressing the entire extracellular domain of the human vascular endothelial growth factor (VEGF) receptor (flt-1) fused to the Fc portion of human IgG. The soluble receptor secreted from AdVEGF-ExR-infected cells bound to VEGF and inhibited VEGF-induced DNA synthesis in endothelial cells. When human lung cancer cell line H157, which produces not only VEGF but also fibroblast growth factor 2 and interleukin 8 at substantial levels, was infected with AdVEGF-ExR, cell growth in vitro was not affected. However, when H157 cells infected with AdVEGF-ExR were injected s.c. into nude mice, tumor formation stopped on the 10th day after reaching a certain size (about 100 mm3), and tumor size declined gradually thereafter. When AdVEGF-ExR was injected into skeletal muscle and uninfected H157 cells were injected s.c. , the soluble receptor was detectable in the circulating blood for 3 weeks, tumor growth ceased after 10 days, and tumor size declined thereafter. Histological examination revealed that intratumor angiogenesis was markedly suppressed, and apoptosis was enhanced. Using the same experimental protocol, a significant suppression of tumor growth was also seen in four of five other lung cancer cell lines, some of which secreted VEGF at nominal levels, at least under normoxic conditions in vitro. Our results demonstrate that adenovirus-mediated expression of a soluble VEGF receptor in a remote organ could inhibit tumor angiogenesis and enhance apoptosis and thereby suppress tumor growth in vivo. Adenovirus-mediated overexpression of a soluble VEGF receptor in a remote organ may have the potential to be a feasible and effective strategy for cancer treatment.
Affine Deligne–Lusztig varieties in affine flag varieties

Abstract This paper studies affine Deligne–Lusztig varieties in the affine flag manifold of a split group. Among other things, it proves emptiness for certain of these varieties, relates some of them to those for Levi subgroups, and extends previous conjectures concerning their dimensions. We generalize the superset method, an algorithmic approach to the questions of non-emptiness and dimension. Our non-emptiness results apply equally well to the p-adic context and therefore relate to moduli of p-divisible groups and Shimura varieties with Iwahori level structure.
123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study.

UNLABELLED The serotonergic system may play an important role in the pathophysiology of major depressive disorder (MDD). Few imaging studies have examined serotonin transporter (SERT) binding in patients with MDD. We hypothesized that SERT binding activity may be altered in patients with MDD. This study compared SERT binding in patients with MDD with that in healthy controls. METHODS We studied SERT activity in 7 patients (22-50 y old) with moderate to severe MDD and 6 healthy controls (24-56 y old) using (123)I-labeled 2-((2-((dimethylamino)methyl) phenyl)thio)-5-iodophenylamine (ADAM) and SPECT brain imaging. Subjects underwent SPECT 4 h after intravenous administration of 185 MBq (5 mCi) of (123)I-ADAM. Images were reconstructed in the axial plane, and region-of-interest demarcations were placed on the midbrain, medial temporal region, and basal ganglia region. RESULTS (123)I-ADAM binding to SERT in the midbrain was significantly lower (P = 0.01) in MDD patients (1.81 +/- 0.07) than in controls (1.95 +/- 0.13). Age-adjusted (123)I-ADAM binding in the midbrain correlated significantly with scores on the Hamilton Depression Rating Scale (r = 0.82; P = 0.02). A significant negative correlation was observed between (123)I-ADAM SERT binding in the midbrain and age in the healthy control group (r = 0.98; P = 0.0002). SERT binding in the basal ganglia or medial temporal regions of interest did not significantly differ between groups. CONCLUSION The findings from this preliminary study suggest the possibility of decreased SERT binding in the midbrain region of patients with MDD, with the degree of decrease correlating with the severity of depressive symptoms. There also appears to be an age-related decline in midbrain (123)I-ADAM SERT binding in healthy subjects.
A grounded theory exploration of deliberate self‐harm in incarcerated women

Abstract The purpose of this study was to explicate a definition of deliberate self‐harm (DSH) and present a model that illustrates the DSH process as experienced by incarcerated women. Grounded theory was used to guide the collection and analysis of data. A circular process of DSH emerged. For the incarcerated women in this study anxiety caused a visceral build‐up of tension that reached a critical level necessitating a need to act in some way to gain relief. DSH supplied the mechanism by which overwhelming tension was released. The temporary relief, however, was soon supplanted by the negative consequences of disciplinary detention imposed as a means of punishment that in turn, lead to more anxiety and anger. Implications: Nurses practicing in corrections need to work towards “decriminalizing” DSH and to develop a prison protocol that gives nurses permission to “just listen” and incarcerated women permission to “just talk” without fear of reprisal.
FFQ: A Fast Single-Producer/Multiple-Consumer Concurrent FIFO Queue

With the spreading of multi-core architectures, operating systems and applications are becoming increasingly more concurrent and their scalability is often limited by the primitives used to synchronize the different hardware threads. In this paper, we address the problem of how to optimize the throughput of a system with multiple producer and consumer threads. Such applications typically synchronize their threads via multi-producer/multi-consumer FIFO queues, but existing solutions have poor scalability, as we could observe when designing a secure application framework that requires high-throughput communication between many concurrent threads. In our target system, however, the items enqueued by different producers do not necessarily need to be FIFO ordered. Hence, we propose a fast FIFO queue, FFQ, that aims at maximizing throughput by specializing the algorithm for single-producer/multiple-consumer settings: each producer has its own queue from which multiple consumers can concurrently dequeue. Furthermore, while we provide a wait-free interface for producers, we limit ourselves to lock-free consumers to eliminate the need for helping. We also propose a multi-producer variant to show which synchronization operations we were able to remove by focusing on a single producer variant. Our evaluation analyses the performance using micro-benchmarks and compares our results with other state-of-the-art solutions: FFQ exhibits excellent performance and scalability.
Effects of 24-Hour Blood Pressure and Heart Rate Recorded With Ambulatory Blood Pressure Monitoring on Recovery From Acute Ischemic Stroke

Background and Purpose— This study used ambulatory blood pressure (BP) monitoring to generate BP and heart rate (HR) profiles soon after stroke onset and evaluated the association between determined values and 3-month stroke outcomes. Methods— We analyzed 24-hour ambulatory BP monitoring records from 104 patients with acute ischemic stroke. Ambulatory BP monitoring was attached at the second and eighth hospitalization days (Days 1 and 7). Both BP and HR were characterized using baseline, mean, maximum, and minimum values and coefficient of variation during 24-hour recording periods. Outcomes at 3 months were assessed as independence according to a modified Rankin Scale score of ⩽2 and poor according to the score of ≥5. Results— Sixty-six (63%) patients achieved independence and 12 (11%) had poor outcomes. Mean ambulatory BP monitoring values changed from 150.5±19.5/85.7±11.3 mm Hg on Day 1 to 139.6±19.3/80.0±11.7 mm Hg on Day 7. After multivariate adjustment, mean values of systolic BP (OR, 0.63; 95% CI, 0.45–0.85), diastolic BP (0.61; 0.37–0.98), pulse pressure (0.55; 0.33–0.85), and HR (0.61; 0.37–0.98) recorded on Day 1 as well as mean HR on Day 7 (0.47; 0.23–0.87) were inversely associated with independence and mean values of systolic BP (1.92; 1.15–3.68), diastolic BP (5.28; 1.92–22.85), and HR (4.07; 1.83–11.88) on Day 1 as well as mean HR on Day 7 (4.92; 1.36–36.99) were positively associated with a poor outcome. Conclusions— All of systolic BP, diastolic BP, pulse pressure, and HR on Day 1 and HR on Day 7 assessed using ambulatory BP monitoring were associated with outcomes of patients with stroke at 3 months.
Complement activation in patients with systemic lupus erythematosus without nephritis.

OBJECTIVE To study the association between disease activity and complement activation prospectively in patients with systemic lupus erythematosus (SLE). PATIENTS AND METHODS Twenty-one SLE patients were examined monthly for 1 yr. Disease activity, autoantibodies, conventional complement tests and the following complement activation products were investigated: C1rs-C1inh complexes, C4bc, Bb, C3a, C3bc, C5a and the terminal SC5b-9 complement complex (TCC). RESULTS Modest variation in disease activity was noted. None of the patients had nephritis. Flare was observed at 27 visits. Four patients had anti-C1q antibodies in conjunction with modestly low C1q concentrations. The complement parameters were rather constant during the observation period. Slightly to moderately decreased C4 (0.05-0.10 g/l) was found in 10 patients and severely decreased C4 (<0.05 g/l) in seven patients. Decreased C4 was not associated with increased complement activation. Complement activation products were either normal or slightly elevated. TCC was the only activation product correlating significantly with score for disease activity at flare. None of the variables tested predicted flares. CONCLUSION Complement tests are of limited importance in routine examination of SLE without nephritis, although TCC is suggested to be one of the most sensitive markers for disease activity.
Role of savings in economic growth of Pakistan

This empirical study aims to examine the relationship between savings and economic growth of Pakistan over the period 1977-2013. Using the autoregressive distributed lag (ARDL) approach to co-integration, the results show that the empirical evidence strongly suggests that domestic savings played important role in economic growth and development of Pakistan in the long-run. The long-run and short-run elasticity of savings are estimated to be 3.072 and 2.071 respectively. Thus, domestic saving is positively and significantly associated to growth in Pakistan.
The attenuated hepatocellular carcinoma-specific Listeria vaccine Lmdd-MPFG prevents tumor occurrence through immune regulation of dendritic cells

Immunotherapy is a promising treatment for liver cancer. Here, we tested the ability of the attenuated hepatocellular carcinoma-specific Listeria vaccine (Lmdd-MPFG) to treat hepatocellular carcinoma (HCC) in a mouse model. Immunization with the vaccine caused a strong anti-tumor response, especially in mice reinfused with dendritic cells (DCs). In mice that were also administered DCs, tumor suppression was accompanied by the strongest cytotoxic T lymphocyte response of all treatment groups and by induced differentiation of CD4+ T cells, especially Th17 cells. Additionally, the Lmdd-MPFG vaccine caused maturation of DCs in vitro. We demonstrated the synergistic effect of TLR4 and NLRP3 or NOD1 signaling pathways in LM-induced DC activation. These results suggest that the Lmdd-MPFG vaccine is a feasible strategy for preventing HCC.
Borel measurable functionals on measure algebras

For Φ,Ψ ∈ A′′, define 〈Φ Ψ, λ〉 = 〈Φ, Ψ · λ〉 (λ ∈ A′) , and similarly for ♦. Thus (A′′, ) and (A′′,♦) are Banach algebras each containingA as a closed subalgebra. The Banach algebra A is Arens regular if and ♦ coincide on A′′, and A is strongly Arens irregular if and ♦ coincide only on A. A subspace X of A′ is left-introverted if Φ · λ ∈ X whenever Φ ∈ A′′ and λ ∈ X . There has been a great deal of study of the two algebras (A′′, ) and (A′′,♦), especially in the case where A is the group algebra (L(G), ? ) or the measure algebra (M(G), ? ) of a locally compact group G. For example, it has been known for a long time that L(G) is strongly Arens irregular for each locally compact group G. On the other hand, each C∗-algebra is Arens regular. Recently, the three participants have studied [5] the second dual of a semigroup algebra; here S is a semigroup, and our Banach algebra is A = (` (S), ? ). We see that the second dual A′′ can be identified with the space M(βS) of complex-valued, regular Borel measures on βS, the Stone–Čech compactification of S. In fact, (βS, ) is itself a subsemigroup of (M(βS), ). See [13] for background on (βS, ). Let G be a locally compact group. The algebra M(G) has been much studied. This algebra is the multiplier algebra of the group algebra L(G). Even in the case where G is the circle group T, the Banach algebra M(G) is very complicated; its character space is ‘much larger’ than the dual group Z of T [10]. Starting at a BIRS ‘Research in Teams’ in September, 2006, the three participants have been studying the algebras (M(G)′′, ) and (L1(G)′′, ). Our work continued at other meetings, some at BIRS, and in 2007 and 2008 we established a number of other results that are contained in [6]. The first part of our memoir [6] studied the second dual space of C0(Ω), where Ω is a locally compact space. This second dual is identified with C(Ω̃) for a certain hyper-Stonean space Ω̃; in particular, Ω̃ is compact and extremely disconnected. The space C(Ω̃) contains as a proper closed C∗-subalgebra the space κ(B(Ω)), which is an isometric copy of B(Ω), the space of bounded Borel functions on Ω. The Dixmier
Optical properties of chemical vapor deposition-grown PtSe2 characterized by spectroscopic ellipsometry

PtSe2, an emerging 2D group-10 transition metal dichalcogenide (TMD), has aroused significant attention recently due to its intriguing physical properties. Here, the optical properties of chemical vapor deposition-grown PtSe2 films with different thicknesses were characterized with nondestructive spectroscopic ellipsometry and Fourier transform infrared spectroscopy. The polarized optical microscopy reveals the isotropic in-plane optical response of the continuous PtSe2 films in a scale size of at least as small as 143 × 108 µm2. The electrical transport characterization and UV-mid infrared absorption spectra reveal the coexistence of both semiconducting and metallic contents in these PtSe2 films, making PtSe2 quite different among the 2D material family. The effective refractive index (n) and the extinction coefficient (k) over a spectra range of 360–1700 nm were obtained. In contrast to other TMDs, the values of n and k of PtSe2 were found to have a strong dependence on the thickness and they decrease as the reduction of thickness. This work is conducive to provide vital parameters for further study on PtSe2 and could facilitate its application in optoelectronic devices.
Generation of HDR Images in Non-static Conditions based on Gradient Fusion

We present a new method for the generation of HDR images in non-static conditions, i.e. hand held camera and/or dynamic scenes, based on gradient fusion. Given a reference image selected from a set of LDR pictures of the same scene taken with multiple time exposure, our method improves the detail rendition of its radiance map by adding information suitably selected and interpolated from the companion images. The proposed technique is free from ghosting and bleeding, two typical artifacts of HDR images built through image fusion in non-static conditions. The advantages provided by the gradient fusion approach will be supported by the comparison between our results and those of the state of the art.
Investment Shocks and Asset Prices

I explore the implications for asset prices and macroeconomic dynamics of shocks that improve real investment opportunities and thus affect the representative household’s marginal utility. These investment shocks generate differences in risk premia due to their heterogeneous impact on firms: they benefit firms producing investment relative to firms producing consumption goods and increase the value of growth opportunities relative to the value of existing assets. Using data on asset returns, I find that a positive investment shock leads to high marginal utility states. A general equilibrium model with investment shocks matches key features of macroeconomic quantities and asset prices.
Assessing fluctuating asymmetry of white-tailed deer antlers in a three-dimensional context

Abstract Fluctuating asymmetry, random departure from perfect symmetry in bilateral traits, has been proposed as an indirect indicator of individual quality. Sexually selected traits, such as deer antlers, are hypothesized to demonstrate decreasing level of fluctuating asymmetry with increasing trait size and decreasing level of fluctuating asymmetry with increasing age. These hypotheses have been previously tested for antlers using linear measurements to quantify fluctuating asymmetry. However, antlers are complex, 3-dimensional traits making it difficult to quantify all forms of visual asymmetry using traditional, linear measurements. It is this visual asymmetry that would be assessed by potential mates and rivals. Therefore, we created 3-dimensional computer models of white-tailed deer (Odocoileus virginianus) antlers to measure visual fluctuating asymmetry. Asymmetry measures of various antler traits were computed using the models by measuring distances from the trait to a vertical and horizontal plane created using coordinate points generated within the model. We found no association between degree of fluctuating asymmetry and trait size, nor was any association found between degree of fluctuating asymmetry and age using either the 3-dimensional measures of asymmetry or traditional, linear measures of asymmetry. Examination of these data suggests that fluctuating asymmetry of white-tailed deer antlers is not a reliable indicator of quality.
Nasopharyngeal Pneumococcal Carriage of Children Attending Day Care Centers in Korea: Comparison between Children Immunized with 7-valent Pneumococcal Conjugate Vaccine and Non-immunized

To confirm the effect of 7-valent pneumococcal conjugate vaccine (PCV7), pneumococcal nasopharyngeal (NP) carriage was compared between vaccinated (3 + 1 doses PCV7) and non-vaccinated children. Vaccinated subjects were recruited from highly vaccinated regions (≥ 60%), Seoul and Incheon whereas control subjects were recruited from Jeju Island where vaccination rates are low (< 15%). NP swabs were obtained from 400 children aged 18-59 months. Serotype and antibiotic susceptibility was analyzed. Pneumococcal carriage rate was 18.0% (36/200) and 31.5% (63/200) for the vaccinated and control group, respectively. Among those vaccinated, 41.7% (15/36) of the serotypes were vaccine-related type (VRT: 6A, 6C, 19A) with the most common serotype 6C. The next common type was non-typable/non-capsule 30.6% (11/36) followed by non-vaccine type 16.7% (6/36) and vaccine type (VT) serotypes were found in only 11.1% (4/36). In contrast, 52.4% (33/63) of the isolates in the control group were VT. Resistance rates for penicillin and erythromycin were lower in the vaccine group (vaccine vs control; penicillin 45.2% vs 71.4%, erythromycin 74.2% vs 90.5%, P < 0.05). Multi-drug resistance was also lower in vaccinated subjects (vaccine vs control; 45.2% vs 69.8%, P < 0.05). PCV7 reduces carriage in VT which leads to replacement of pneumococci by antibiotic susceptible VRT or non-vaccine type strains.