Miracle-dz/UniFAR-FTUs huggingface dataset:
Modifying the System for Observing Fitness Instruction Time to Measure Teacher Practices Related to Physical Activity Promotion: SOFIT+

ABSTRACT The System for Observing Fitness Instruction Time (SOFIT) is commonly used to measure variables related to physical activity during physical education (PE). However, SOFIT does not yield detailed information about teacher practices related to children’s moderate-to-vigorous physical activity (MVPA). This study describes the modification of SOFIT (referred to as SOFIT+) to measure teacher practices related to students’ MVPA during PE lessons. Teacher practices that (a) promote and (b) limit children’s MVPA were identified and operationally defined via a literature review and Delphi Method. Reliability and validity data for SOFIT+ were obtained from 20 video recorded elementary PE lessons. Validity of teacher behaviors included in SOFIT+ was established using students’ accelerometer-derived MVPA. Twenty-seven teacher practices were identified. Inter-rater agreement ranged from 75.8% to 99.1% across 724 reliability scans. Six and seven practices were independently related to girls’ and boys’ MVPA, respectively. For example, during elimination activities, boys and girls were less likely to engage in MVPA. Boys were up to 1.51 times more likely to engage in MVPA while girls were up to 2.86 times more likely to engage in MVPA when a greater number of teacher practices were observed concurrently. Findings provide preliminary reliability and validity for SOFIT+, an instrument to comprehensively measure teacher practices related to children’s MVPA during PE.
The rating and dating complex.

C OURTSHIP may be defined as the set of processes of association among the unmarried from which, in time, permanent matings usually emerge. This definition excludes those associations which cannot normally eventuate in marriage-as between Negro and white-but allows for a period of dalliance and experimentation. In the present paper we propose to discuss the customs of courtship which prevail among college students. Courtship practices vary from one culture group to another. In many cultures marriage eventuates from a period of sexual experimentation and trial unions; in others the innocence of the unmarried is carefully guarded until their wedding day. In some cultures the bride must be virginal at marriage; in others this is just what she must not be. Sometimes the young are allowed no liberty of choice, and everything is determined for them by their elders. Sometimes persons marry in their own age group, but in other societies older men pre-empt the young women for themselves. Although there are endless variations in courtship customs, they are always functionally related to the total configuration of the culture and the biological needs of the human animal. It is helpful to remember that in a simple, undifferentiated, and stable society a long and complex process of choosing a mate is apparently not so necessary or desirable as in our own complex, differentiated, and rapidly changing society. ' The mores of courtship in our society are a strange composite of social heritages from diverse groups and of new usages called into existence by the needs of the time. There is a formal code of courtship which is still nominally in force, although departures from it are very numerous; the younger generation seems to find the superficial usages connected with the code highly amusing, but it is likely that it takes the central ideas quite seriously. The formal code appears to be derived chiefly from the usages of the English middle classes of a generation or so ago, although there are, of course, many other elements in it. The usual or intended mode of operation of the formal mores of courtship-in a sense their "function"is to induct young persons into marriage by a series of progressive commitments. In the solidary peasant community, in the frontier community, among the English middle classes of
Atmosphere–Ocean Variations in the Indo-Pacific Sector during ENSO Episodes

Abstract The influences of El Nino–Southern Oscillation (ENSO) events on air–sea interaction in the Indian–western Pacific (IWP) Oceans have been investigated using a general circulation model. Observed monthly sea surface temperature (SST) variations in the deep tropical eastern/central Pacific (DTEP) have been inserted in the lower boundary of this model through the 1950–99 period. At all maritime grid points outside of DTEP, the model atmosphere has been coupled with an oceanic mixed layer model with variable depth. Altogether 16 independent model runs have been conducted. Composite analysis of selected ENSO episodes illustrates that the prescribed SST anomalies in DTEP affect the surface atmospheric circulation and precipitation patterns in IWP through displacements of the near-equatorial Walker circulation and generation of Rossby wave modes in the subtropics. Such atmospheric responses modulate the surface fluxes as well as the oceanic mixed layer depth, and thereby establish a well-defined SST anom.
Bayesian Estimation of Principal Components for Functional Data

The area of principal components analysis (PCA) has seen relatively few contributions from the Bayesian school of inference. In this paper, we propose a Bayesian method for PCA in the case of functional data observed with error. We suggest modeling the covariance function by use of an approximate spectral decomposition, leading to easily interpretable parameters. We study in depth the choice of using the implied distributions arising from the inverse Wishart prior and prove a convergence theorem for the case of an exact nite dimensional rep- resentation. We also discuss computational issues as well as the care needed in choosing hyperparameters. A simulation study is used to demonstrate competitive performance against a recent frequentist procedure, particularly in terms of the principal component estimation. Finally, we apply the method to a real dataset, where we also incorporate model selection on the dimension of the
Isolation of Highly Suppressive CD25+FoxP3+ T Regulatory Cells from G-CSF-Mobilized Donors with Retention of Cytotoxic Anti-Viral CTLs: Application for Multi-Functional Immunotherapy Post Stem Cell Transplantation

Previous studies have demonstrated the effective control of cytomegalovirus (CMV) infections post haematopoietic stem cell transplant through the adoptive transfer of donor derived CMV-specific T cells (CMV-T). Strategies for manufacturing CMV immunotherapies has involved a second leukapheresis or blood draw from the donor, which in the unrelated donor setting is not always possible. We have investigated the feasibility of using an aliquot of the original G-CSF-mobilized graft as a starting material for manufacture of CMV-T and examined the activation marker CD25 as a targeted approach for identification and isolation following CMVpp65 peptide stimulation. CD25+ cells isolated from G-CSF-mobilized apheresis revealed a significant increase in the proportion of FoxP3 expression when compared with conventional non-mobilized CD25+ cells and showed a superior suppressive capacity in a T cell proliferation assay, demonstrating the emergence of a population of Tregs not present in non-mobilized apheresis collections. The expansion of CD25+ CMV-T in short-term culture resulted in a mixed population of CD4+ and CD8+ T cells with CMV-specificity that secreted cytotoxic effector molecules and lysed CMVpp65 peptide-loaded phytohaemagglutinin-stimulated blasts. Furthermore CD25 expanded cells retained their suppressive capacity but did not maintain FoxP3 expression or secrete IL-10. In summary our data indicates that CD25 enrichment post CMV stimulation in G-CSF-mobilized PBMCs results in the simultaneous generation of both a functional population of anti-viral T cells and Tregs thus illustrating a potential single therapeutic strategy for the treatment of both GvHD and CMV reactivation following allogeneic haematopoietic stem cell transplantation. The use of G-CSF-mobilized cells as a starting material for cell therapy manufacture represents a feasible approach to alleviating the many problems incurred with successive donations and procurement of cells from unrelated donors. This approach may therefore simplify the clinical application of adoptive immunotherapy and broaden the approach for manufacturing multi-functional T cells.
The threat of Asian dust storms on asthma patients: A population-based study in Taiwan

This study explores the relationship between Asian dust storms (ADSs), asthma hospital admissions and average medical cost discharge. We adopt the hospitalisation data from the Taiwan National Health Insurance research database covering the period from 2000 to 2009. The autoregressive integrated moving average with exogenous variables (ARIMAX) analyses were performed to explore the relationship between ADS and asthma hospital admissions, adjusting for temperature, air pollutants and season dummy. The results show that ADS events do generate a critical influence upon the occurrences of asthma on post-ADS events from days 1 through 3, with an average of 17–20 more hospitalised admissions, and have stronger effects on preschool children, middle-aged people and the elderly. From the perspective of medical expenses, the cost of hospitalised admissions for asthma substantially rises daily, on average, by NT$634,698 to NT$787,407 during ADS event days. This study suggests that government should establish a forecast and alert system and release warnings about dust storms, so that the individuals predisposed to asthma can take precautionary measures to reduce their outdoor exposure. Consequently, personal risk and medical expenditure could be reduced significantly, especially for preschool children, middle-aged people and the elderly with asthma.
The Role of Knowledge, Control Beliefs, and Surface Types on the Risk Judgments of Environmental Service Workers

The hands of healthcare workers are the number one source of health care acquired infections. Every one of these infections could be prevented with proper hand hygiene, yet compliance rates are poor. Pathogens can be transmitted through touching contaminated skin or touching a contaminated surface -missed hand hygiene is most common after touching a patient’s surroundings. We investigated the risk judgments of a sample of environmental service workers on touching skin versus surfaces and found that they judged touching surfaces as less likely to transmit pathogens than touching skin. Knowledge level concerning hand hygiene practices and perceived health competency were also assessed and related to risk judgments.
Uric Acid and Survival in Chronic Heart Failure: Validation and Application in Metabolic, Functional, and Hemodynamic Staging

Background—Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF). Methods and Results—For the derivation study, 112 patients with CHF (age 59±12 years, peak oxygen consumption [&OV0312;o2] 17±7 mL/kg per minute) were recruited. In separate studies, we validated the prognostic value of UA (n=182) and investigated the relationship between MFH score and the decision to list patients for heart transplantation (n=120). In the derivation study, the best mortality predicting UA cutoff (at 12 months) was 565 &mgr;mol/L (9.50 mg/dL) (independently of age, peak &OV0312;o2, left ventricular ejection fraction, diuretic dose, sodium, creatinine, and urea;P <0.0001). In the validation study, UA ≥565 &mgr;mol/L predicted mortality (hazard ratio, 7.14;P <0.0001). In 16 patients (from both studies) with UA ≥565 &mgr;mol/L, left ventricular ejection fraction ≤25% and peak &OV0312;o2 ≤14 mL/kg per min (MFH score 3), 12-month survival was lowest (31%) compared with patients with 2 (64%), 1 (77%), or no (98%, P <0.0001) risk factor. In an independent study, 51% of patients with MFH score 2 and 81% of patients with MFH score 3 were listed for transplantation. The positive predictive value of not being listed for heart transplantation with an MFH score of 0 or 1 was 100%. Conclusions—High serum UA levels are a strong, independent marker of impaired prognosis in patients with moderate to severe CHF. The relationship between serum UA and survival in CHF is graded. MFH staging of patients with CHF is feasible.
Cumulative Lifetime Migraine Incidence in Women and Men

The aim was to estimate lifetime sex and age-specific incidence of migraine. Data are from the American Migraine Prevalence and Prevention study, a mailed survey sent to 120 000 US households. Age-specific incidence was estimated using self-reported data relevant to identification of migraine cases, age of onset of migraine and age at interview. Migraine incidence peaked between the ages of 20 and 24 years in women (18.2/1000 person-years) and the ages of 15 and 19 years in men (6.2/1000 person-years). Cumulative incidence was 43± in women and 18± in men. Median age of onset was 25 years among women and 24 years among men. Onset in 50± of cases occurred before age 25 and in 75± before age 35 years. Four of every 10 women and two of every 10 men will contract migraine in their lifetime, most before age 35 years. The incidence estimates from this analysis are consistent with those reported in previous longitudinal studies.
Inhibition by Rapamycin of PDGF- and bFGF‐Induced Human Tenon Fibroblast Proliferation in Vitro

PurposeFibrosis of subconjunctival tissues is a major cause of bleb failure following glaucoma filtration surgery. The aim of the present investigation was to demonstrate the effect of Rapamycin, a clinically relevant macrolide antibiotic with potent immunosuppressive properties, on human Tenon fibroblast proliferation induced by platelet-derived growth factor and basic fibroblast growth factor. MethodsPrimary Tenon fibroblast cultures were derived from patients undergoing trabeculectomies or routine cataract extractions. Rapamycin was added in concentrations of 0.1–100 ng/ml with or without 3–30 ng/ml of porcine platelet-derived growth factor or of human recombinant basic fibroblast growth factor. Two days after treatment, the cells were examined and counted. The results were expressed as the percent of cell growth in treated culture relative to its untreated control. ResultsRapamycin was not cytotoxic at any of the concentrations tested. Inhibition of platelet-derived growth factor-induced Tenon fibroblast proliferation occurred with all doses of Rapamycin, the most marked effect being observed with 30 ng/ml (60% inhibition, p < 0.001). In contrast, optimal inhibition of basic fibroblast growth factor-induced proliferation was only 37% (p < 0.01), achieved with 10 ng/ml of the peptide. ConclusionRapamycin potently inhibits platelet-derived growth factorinduced fibroblast proliferation in vitro without any apparent cytotoxicity. It may eventually prove to be a useful adjunct to glaucoma filtration surgery.
Better cognitive and psychopathologic response to donepezil in patients prospectively diagnosed as dementia with Lewy bodies: a preliminary study

In several retrospective post‐mortem studies, patients meeting clinical criteria for Alzheimer's disease (AD) who gained the greatest cognitive benefit from treatment with an acetylcholinesterase (AChE) inhibitor were found to have neocortical Lewy bodies accompanying classical AD neuropathology. This ‘dementia with Lewy bodies’ (DLB) subtype manifests both parkinsonian and psychopathologic features that set it apart from ‘pure’ AD (hereafter called AD). In the present preliminary study, 16 dementia patients were prospectively categorized as having DLB versus AD. Subjects were also categorized according to their profile on surface electromyographic (EMG) measures demonstrated in prior work to be analogues of clinically observed parkinsonian extrapyramidal signs (EPS). All patients were prescribed the AChE inhibitor donepezil (5 mg per day). At baseline and at 6 months, patients underwent cognitive testing with the Mini‐Mental State Examination (MMSE) while caregivers assessed their psychopathologic status using the Behavioral Symptoms in Alzheimer's Disease (BEHAVE‐AD) scale. The tester was blinded to the AD versus DLB classification of the patients. AD cases (N=12) had only a slight increase in cognitive scores, while DLB patients' (N=4) mean MMSE scores increased to a significantly greater degree. Furthermore, patients categorized by EMG as EPS positive (N=8) attained an increase in their mean MMSE score from baseline to 6 months that differed significantly from a decline in MMSE observed among their EPS negative (N=4) counterparts. For all subjects, an increase in MMSE scores across 6 months of treatment correlated with a decline in BEHAVE‐AD scores. Copyright © 2000 John Wiley & Sons, Ltd.
Preventing Symptoms of Depression by Teaching Adolescents That People Can Change

The transition to high school coincides with an increase in the prevalence of depressive symptoms. Could this be due in part to increasing beliefs about the fixedness of personal traits at a time of frequent social setbacks? And could teaching adolescents that people can change help prevent the increase in depressive symptoms? A longitudinal intervention experiment involved three independent samples of students entering high school (N = 599). A brief self-administered reading and writing activity taught an incremental theory of personality—the belief that people’s socially relevant characteristics have the potential to change. The intervention reduced the incidence of clinically significant levels of self-reported depressive symptoms 9 months postintervention by nearly 40% among adolescents assigned to the intervention condition, compared with control participants. Analyses of symptom clusters, measures of self-esteem, and measures of natural language use explored the outcomes that did and did not show treatment effects. Moderation analyses confirmed theoretical expectations. Among adolescents assigned to the control condition, those who endorsed more of an entity theory of personality—believing people cannot change—showed greater increases in depressive symptoms during the year. The effect of this risk factor was eliminated by the intervention.
The association between anti-carbamylated protein (anti-CarP) antibodies and radiographic progression in early rheumatoid arthritis: a study exploring replication and the added value to ACPA and rheumatoid factor

Objective Anti-carbamylated protein (anti-CarP) antibodies are reported to associate with more radiographic progression within the total rheumatoid arthritis (RA) population and anti-citrullinated peptide antibody (ACPA)-negative subgroup. We explored the association of anti-CarP with radiographic progression in RA and aimed to replicate the association and evaluate the added value of anti-CarP antibodies in relation to ACPA and rheumatoid factor (RF). Methods 576 Swedish and 628 Dutch patients with RA (2394 and 3247 sets of radiographs, respectively) were longitudinally studied. Replication was restricted to the Swedish patients. In both cohorts, the association of anti-CarP with radiographic progression was determined in strata of patients with similar ACPA and RF status; results of both cohorts were combined in fixed-effect meta-analyses. The net percentage of patients for whom the radiographic progression in 5 years was additionally correctly classified when adding anti-CarP to a model including ACPA and RF was evaluated. Results Anti-CarP associated with radiographic progression in the total Swedish RA population (beta=1.11 per year, p=8.75×10−13) and in the ACPA-negative subgroup (beta=1.14 per year, p=0.034). Anti-CarP associated with more radiographic progression in the strata of ACPA-positive/RF-negative, ACPA-negative/RF-positive and ACPA-positive/RF-positive patients with RA (respective p values 0.014, 0.019 and 0.0056). A model including ACPA and RF correctly classified 54% and 57% of the patients; adding anti-CarP to this model did not increase these percentages (54% and 56% were correctly classified). Conclusions Anti-CarP antibodies associated with more severe radiographic progression in the total and ACPA-negative RA population. Anti-CarP-positivity had a statistically significant additive value to ACPA and RF, but did not improve correct classification of patients.
The Relationship Between Intracholecystic Papillary-Tubular Neoplasms and Invasive Carcinoma of the Gallbladder

Introduction. The term intracholecystic papillary-tubular neoplasm (ICPN) is suggested by some authors for a group of exophytic lesions of the gallbladder. In our study, demographic, pathological, and immunohistochemical features of 45 ICPN cases and their relationship with invasive carcinoma were analyzed. Material and methods. A total of 45 ICPN cases were retrieved out of 7334 cholecystectomies performed between1996 and 2014. Cases were evaluated with regard to demographic, pathological, and immunohistochemical features. Correlation between the clinical and histopathological data and occurrence of invasion was sought. Results. The incidence of ICPN was 0.61% in our series. Invasive carcinoma was observed in 56% of cases. Factors associated with invasion were diffuse high-grade dysplasia (P = .002), papillary growth pattern (P = .001), greatest diameter of the lesion, and high Ki67 proliferation index (P < .0001). Discussion. Some authors have reported that small intracholecystic exophytic lesions without high-grade dysplasia are considered to be inconsequential. However, there are not enough data concerning the features of large lesions with high-grade dysplasia and their prognoses. Our data suggest that cases with diffuse high-grade dysplasia and tubulopapillary/papillary growth pattern, large tumor size, and high Ki67 proliferation index should be studied for the presence of invasion.
Labour-Market Institutions and Macroeconomic Shocks

Macroeconomic shocks and labour-market institutions jointly determine employment growth and economic performance. The effect of shocks depends on the nature of these institutions and the effect of institutional change depends on the macroeconomic environment. It follows that a given set of institutions may be appropriate at certain times in some countries while not appropriate elsewhere. We derive a dynamic model of labour demand in which the effect of firing costs on labour demand depends on the macroeconomic environment: When the level of macroeconomic activity is expected to drop and/or the trend rate of productivity growth is small, a rise in firing costs affects mainly (and adversely) the hiring decision and not the firing decision. This makes firing costs harmful when they may appear to be most appropriate. The intuition behind these results is quite straightforward: When managers fear that demand may fall in the future they value the right to fire workers. It follows that by making this option more costly, firing costs reduce the value of workers with adverse consequences for hiring and firing.