Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacologic Treatment of Equine Self-Mutilation Syndrome

The effects of drugs that either stimulate or inhibit central opioid, dopamine, norepinephrine, and serotonin neurotransmitter systems were examined in horses demonstrating signs of equine self-mutilation syndrome (ESMS), a condition similar to Tourette’s syndrome in humans. Eight flankbiting horses with ESMS were recruited for the study. A series of drugs selected for their activity on the aforementioned neurotransmitter systems were administered to the horses in a saline-controlled behavioral study. Specific behaviors associated with the syndrome were videotaped for 4 hours following administration of drug or saline. Behaviors recorded hourly during each phase of the study were compared with those of a composite saline control baseline to determine whether there were significant differences among the treatments. Acepromazine, a dopamine blocker, produced a significant reduction in the primary ESMS behaviors of self-mutilative attempts and hemiballismus. Detomidine, an α -2 antagonist, also produced a significant (P < .05) reduction in these behaviors, as did the
Exercise capacity with special reference to type 2 diabetes

Physical inactivity and obesity is a growing health problem world wide. Three different samples with a wide range of glucose tolerance were included in the thesis to represent a wider population. The exercise capacity was studied in one group of healthy sedentary middle aged men with normal glucose tolerance in study I and II. In a group of elderly men with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and with type 2 diabetes (T2D) was the influence of insulin sensitivity on exercise capacity studied (Study III). Exercise testing and exercise training in individuals with T2D was examined in a group of middle aged women with T2D in study IV and V. The performance of a maximal incremental cycle test in sedentary healthy male subjects was highly affected by lower extremity muscular strength and muscular endurance (Study I). Also upper body muscular strength correlated to exercise capacity as measured by cycle ergometry. When exercise capacity and muscular strength of the upper body increased in response to combined supervised group training, the correlation between muscular strength of the upper body and exercise capacity improved (Study II). Exercise capacity assessed during cycling was affect by whole body insulin sensitivity and the waist-hip ratio (Study III). Also, fibre type composition (Study I and III) and capillary density (Study III) contributed to peak exercise capacity. Estimation of VO2peak according to Astrand sub-maximal exercise testing significantly overestimates directly measured VO2peak in women with T2D (Study IV). Improved insulin sensitivity appeared to be related to exercise intensity rather than duration, whereas improved HbA1c appeared to be related to exercise volume in T2D women (Study V). Though closely related, there may be different indices explaining VO2peak and WRpeak. Muscular strength and muscular endurance of not only the legs but also the arms and trunk may be important aspects of peak exercise capacity during a cycle test in healthy sedentary men. Exercise capacity is independently related to insulin sensitivity, muscle fibre composition and waist/hip ratio in subjects with NGT, IGT and T2D whom are matched for age and BMI. This suggests that metabolic abnormalities in skeletal muscle are of prime importance for the reduction in exercise capacity in over a wide range of insulin sensitivity. Sub-maximal tests should be used with caution in patients with T2D. Improvement in insulin sensitivity after six months combined supervised group training in female diabetic subjects is related to exercise intensity, whereas the reduction in HbA1c is related mainly to training volume. Metabolic effects of training may be seen in the absence of improved exercise capacity.
Helicobacter pylori colonization is inversely associated with childhood asthma.

BACKGROUND Asthma, a serious health problem worldwide, is becoming more common. Colonization with Helicobacter pylori, a major human indigenous (commensal) microbe, during early life may be relevant to the risk of childhood asthma. METHODS We conducted cross-sectional analyses, using data from 7412 participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2000, to assess the association between H. pylori and childhood asthma. RESULTS H. pylori seropositivity was inversely associated with onset of asthma before 5 years of age and current asthma in children aged 3-13 years. Among participants 3-19 years of age, the presence of H. pylori was inversely related to ever having had asthma (odds ratio [OR], 0.69; 95% confidence interval [CI], 0.45-1.06), and the inverse association with onset of asthma before 5 years of age was stronger (OR, 0.58; 95% CI, 0.38-0.88). Among participants 3-13 years of age, H. pylori positivity was significantly inversely associated with current asthma (OR, 0.41; 95% CI, 0.24-0.69). H. pylori seropositivity also was inversely related to recent wheezing, allergic rhinitis, and dermatitis, eczema, or rash. CONCLUSIONS This study is the first to report an inverse association between H. pylori seropositivity and asthma in children. The findings indicate new directions for research and asthma prevention.
Adolescent Coping Across Time: Implications for Psychiatric Mental Health Nurses

This article compares rural adolescents' coping responses before and after the behavioral intervention Teaching Kids to Cope with Anger (TKC-A). A quasi-experimental design was used, that included 94 (intervention) and 85 (control) students who were enrolled in three high schools in rural southwestern Pennsylvania. Results showed no statistically significant differences between the intervention and control groups' coping responses following the TKC- A intervention. The majority of youth in this study demonstrated healthy coping skills. In the future, the TKC-A needs to be integrated into the high school curriculum as a health promotion effort that is tailored to adolescents.
Prognostic Role of the Circulating Tumor Cells Detected by Cytological Methods in Gastric Cancer: A Meta-Analysis

Objective. We performed a meta-analysis of available studies to assess the prognostic value of circulating tumor cells detected by cytological methods for patients with gastric cancer. Methods. Two authors systematically searched the studies independently with key words in PubMed, MEDLINE, EMBASE, Science Citation Index Expanded, and Cochrane Library (from inception to April 2016). The estimated hazard ratio, risk ratio, odds ratio, and their 95% confidence intervals were set as effect measures. All analyses were performed by STATA 12.0. Results. Sixteen studies were included in this meta-analysis. CTCs-high status was significantly associated with poor overall survival (HR = 2.23, 95% CI: 1.86–2.66) and progression-free survival (HR = 2.02, 95% CI: 1.36–2.99). CTCs-high status was also associated with depth of infiltration (OR = 2.07, 95% CI: 1.16–3.70), regional lymph nodes metastasis (OR = 1.85, 95% CI: 1.26–2.71), and distant metastasis (OR = 2.83, 95% CI: 1.77–4.52). For unresectable gastric cancer patients, CTCs-high status was significantly associated with poor overall survival, progression-free survival, and disease control rate before and during chemotherapy group. Conclusions. Our meta-analysis has evidenced the significant prognostic value of CTCs detected for both PFS and OS in gastric cancer patients. For patients treated with chemotherapy alone, we proved that CTCs detected by cytological method showed a significant prognostic value and poor response to chemotherapy.
Effect of exercise‐induced muscle damage on vascular function and skeletal muscle microvascular deoxygenation

This paper investigated the effects of unaccustomed eccentric exercise‐induced muscle damage (EIMD) on macro‐ and microvascular function. We tested the hypotheses that resting local and systemic endothelial‐dependent flow‐mediated dilation (FMD) and microvascular reactivity would decrease, V˙O2max would be altered, and that during ramp exercise, peripheral O2 extraction, evaluated via near‐infrared‐derived spectroscopy (NIRS) derived deoxygenated hemoglobin + myoglobin ([HHb]), would be distorted following EIMD. In 13 participants, measurements were performed prior to (Pre) and 48 h after a bout of knee extensor eccentric exercise designed to elicit localized muscle damage (Post). Flow‐mediated dilation and postocclusive reactive hyperemic responses measured in the superficial femoral artery served as a measurement of local vascular function relative to the damaged tissue, while the brachial artery served as an index of nonlocal, systemic, vascular function. During ramp‐incremental exercise on a cycle ergometer, [HHb] and tissue saturation (TSI%) in the m. vastus lateralis were measured. Superficial femoral artery FMD significantly decreased following EIMD (pre 6.75 ± 3.89%; post 4.01 ± 2.90%; P < 0.05), while brachial artery FMD showed no change. The [HHb] and TSI% amplitudes were not different following EIMD ([HHb]: pre, 16.9 ± 4.7; post 17.7 ± 4.9; TSI%: pre, 71.0 ± 19.7; post 71.0 ± 19.7; all P > 0.05). At each progressive increase in workload (i.e., 0–100% peak), the [HHb] and TOI% responses were similar pre‐ and 48 h post‐EIMD (P > 0.05). Additionally, V˙O2max was similar at pre‐ (3.0 ± 0.67 L min−1) to 48 h post (2.96 ± 0.60 L min−1)‐EIMD (P > 0.05). Results suggest that moderate eccentric muscle damage leads to impaired local, but not systemic, macrovascular dysfunction.
p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells.

Ras expression has been suggested as a marker for tumor aggressiveness of breast cancer,including the degrees of invasion and tumor recurrence.We showed previously that H-ras, but not N-ras, up-regulates matrix metalloproteinase 2 expression and induces invasive phenotype in MCF10A human breast epithelial cells (A. Moon, et al. Int. J. Cancer, 85: 176-181, 2000). In this study, we show that H-ras also promotes cell motility more effectively than N-ras in MCF10A cells. We have investigated H-ras-specific signaling pathway(s) critical for H-ras-mediated cell motility and invasive phenotype. Whereas neither H-ras nor N-ras activated c-Jun NH(2)-terminal kinase 1, both H-ras and N-ras effectively activated extracellular signal-regulated protein kinase (ERK) -1,2. Importantly, prominent activation of p38 mitogen-activated protein kinase was shown only in H-ras-activated cells but not in N-ras-activated MCF10A cells. Functional significance of H-ras-activated p38 in invasiveness and cell motility was evidenced by studies using SB203580, a chemical inhibitor of p38, and a dominant-negative construct of p38. Whereas inhibition of c-Jun NH(2)-terminal kinase 1 activity had no effect on H-ras-induced MCF10A cell invasion and motility, the inhibition of the ERK pathway using a chemical inhibitor PD98059 or dominant-negative mutant of mitogen-activated protein/ERK kinase 1, an activator of ERKs, significantly reduced H-ras-induced invasion and migration. We also provide evidence that p38 and, to a lesser degree, ERKs, are critical for H-ras-mediated up-regulation of matrix metalloproteinase 2. Taken together, the present study shows that H-ras activation of both p38 and ERKs induces cell invasion and motility, whereas N-ras activation of ERKs alone is not sufficient. This study reveals the p38 kinase as a key signaling molecule differentially regulated by H-ras and N-ras, leading to H-ras-specific cell invasive and migrative phenotypes in human breast epithelial cells.
Developmental Profile and Diagnoses in Children Presenting with Motor Stereotypies

Introduction Motor stereotypies represent a typical example of the difficulty in distinguishing non-clinical behaviors (physiological and transient) from symptoms or among different disorders [“primary stereotypies,” associated with autistic spectrum disorder (ASD), intellectual disabilities, genetic syndromes, and sensory impairment]. The aim of this study was to obtain an accurate assessment on the relationship between stereotypies and neurodevelopmental disorders. Methods We studied 23 children (3 girls), aged 36–95 months, who requested a consultation due to the persistence or increased severity of motor stereotypies. None of the patients had a previous diagnosis of ASD. The assessment included the Motor Severity Stereotypy Scale (MSSS), the Repetitive Behavior Scale-Revised (RBS-R), the Raven’s Colored Progressive Matrices, the Child Behavior CheckList for ages 1½–5 or 4–18 (CBCL), the Social Responsiveness Scale (SRS), and the Autism Diagnostic Observation Schedule-second edition (ADOS 2). Results All patients were showing motor stereotypies for periods of time varying from 6 to 77 months. The MSSS showed that each child had a limited number of stereotypies; their frequency and intensity were mild. The interference of stereotypies was variable; the impairment in daily life was mild. The RBS-R scores were positive for the subscale of “stereotypic behaviors” in all children. Moreover, several children presented other repetitive behaviors, mainly “ritualistic behavior” and “sameness behavior. ” All patients showed a normal cognitive level. The CBCL evidenced behavioral problems in 22% of the children: internalizing problems, attention, and withdrawn were the main complaints. On the SRS, all but one of the tested patients obtained clinical scores in the clinical range for at least one area. On the ADOS 2, 4 patients obtained scores indicating a moderate level of ASD symptoms, 4 had a mild level, and 15 showed no or minimal signs of ASD. Discussion Motor stereotypies in children with normal cognitive level represent a challenging diagnostic issue for which a finely tailored assessment is mandatory in order to define a precise developmental profile. Thus, careful and cautious use of standardized tests is warranted to avoid misdiagnosis. Furthermore, it is hard to consider motor stereotypies, even the primary ones, exclusively as a movement disorder.
Pregnancy in multiple sclerosis patients treated with immunomodulators prior to or during part of the pregnancy: a descriptive study in the Spanish population

Objectives To study the management of pregnancy in multiple sclerosis (MS) patients on immunomodulatory therapy (IMT) in routine clinical practice and to analyze pregnancy outcomes and the clinical course of MS around pregnancy. Methods Retrospective, multicentric study in Spain in MS patients receiving IMT before conception and followed for at least three months post-partum. Results A total of 1286 medical records were reviewed. Eighty-eight pregnancies were identified in 74 (6%) women, 66% of which were unexposed and 34% exposed pregnancies. In most cases, IMT was discontinued before conception and resumed shortly after delivery. Accidental exposure to IMT did not lead to higher rates of abortions (P = 0.76) or malformations. The relapse rate was decreased during pregnancy (0.31 versus 0.61 in the pre-pregnancy year) and increased after delivery (0.87 on month 3), returning to pre-conception values on month 12. The median EDSS score was not increased during the study. Conclusions Discontinuation of IMT before conception, and resumption shortly after delivery was the most frequent clinical practice procedure. Accidental exposure to IMT did not affect pregnancy outcomes or increased malformation rates. Pregnancy was associated with a reduced relapse rate. No factor was found to predict the risk of relapses during or after pregnancy. Multiple Sclerosis 2007; 13: 981—984. http://msj.sagepub. com
Seismic anisotropy in eastern Africa, mantle flow, and the African superplume

New estimates of seismic anisotropy from shear wave splitting measurements in eastern Africa reveal a pattern of seismic anisotropy dominated by a NE alignment of fast polarization directions with local changes around the thick Archean lithosphere of the Tanzania craton. The overall pattern is consistent with mantle flow from the African superplume but not with absolute plate motion, a plume head, or fossil anisotropy in the lithosphere. In combination with tomographic images of the African superplume, this finding suggests that plateau uplift, volcanism, and continental breakup along the Afro‐Arabian rift system is strongly influenced by flow from the lower mantle and indicates a connection between lower mantle processes and the tectonic deformation of the Earth's surface.
Identification of Emotion from Body Movements: A Cross-Cultural Study of Americans and Japanese

In the present study American and Japanese subjects' judgments of emotional cues in body movements were compared, when facial information was excluded. Seven fundamental emotions of joy, surprise, fear, sadness, disgust, anger, contempt and three affective-cognitive structures for the emotions of affection, anticipation, and acceptance were displayed by four Japanese actors/actresses with their backs turned toward the viewer. The emotions of sadness, fear, and anger as expressed in kinetic movement showed high agreement between the two cultural groups. Joy and surprise, even though they are classified as fundamental emotions, contained some cultural components that affected the judgments. Furthermore, USA subjects successfully identified disgust as portrayed by Japanese actors/actresses, but Japanese subjects did not identify the expressions of disgust or contempt. Affection, anticipation, and acceptance have some cultural components that are interpreted differently by Japanese and Americans, and this accounted for some of the misunderstandings. Nevertheless, most of the scenes depicting emotions and affective-cognitive structures emotions were correctly identified by the subjects of each culture.
Direct oral anticoagulants as alternative treatment options for the effective long-term treatment of patients with pulmonary embolism in primary care: a review

Abstract Pulmonary embolism (PE) represents a potentially life-threatening venous thromboembolic disorder, and prompt treatment is vital to prevent early mortality. However, diagnosis of PE is complicated by the range of signs and symptoms with which it presents. Clinical risk scores, imaging techniques, and laboratory tests are recommended in clinical guidelines to aid diagnosis, and risk stratification strategies can be used to inform treatment decisions. Long-term anticoagulation is key to avoid the risk of later complications of acute PE, such as recurrent venous thromboembolism and chronic thromboembolic pulmonary hypertension. Rivaroxaban is a direct oral anticoagulant that has been approved for the treatment of PE (and deep vein thrombosis) and prevention of recurrent venous thromboembolism; other direct oral anticoagulants have undergone phase III trials for these indications. These agents may provide advantages over traditional anticoagulants, such as vitamin K antagonists, because they are administered at fixed doses and do not require routine coagulation monitoring. These advantages may improve patient adherence and aid general practitioners by simplifying long-term management of PE in daily primary care.
Individual differences in strategies for syllogistic reasoning

Current theories of reasoning such as mental models or mental logic assume a universal cognitive mechanism that underlies human reasoning performance. However, there is evidence that this is not the case, for example, the work of Ford (1995), who found that some people adopted predominantly spatial and some verbal strategies in a syllogistic reasoning task. Using written and think-aloud protocols, the present study confirmed the existence of these individual differences. However, in sharp contrast to Ford, the present study found few differences in reasoning performance between the two groups, in terms of accuracy or type of conclusion generated. Hence, reasoners present an outward appearance of ubiquity, despite underlying differences in reasoning processes. These findings have implications for theoretical accounts of reasoning, and for attempts to model reasoning data. Any comprehensive account needs to account for strategic differences and how these may develop in logically untrained individuals.
What is behind child utterances?

ABSTRACT According to Schlesinger (1973) there are two errors in our research on language development: (a) we attribute too much underlying structure to child utterances; (b) we interpret child language in terms of adult language. In response, we restate the types of evidence we have used to derive semantic representations for child utterances, and emphasize that only such representations can make sense of the way the child uses his language. One of the reasons that child sentences are brief in comparison with the structure they communicate is that the child communicates by using the immediate situation. He constructs parts of the semantic structure not conceptually but at the sensory–motor level and communicates them deictically. Nevertheless the entire structure is under the child's control. We further clarify our notion of adverbial, which has permitted us to conclude that adverbials are absent in very early speech.
Intensity of Smiling in Facebook Photos Predicts Future Life Satisfaction

Does the extent to which people are smiling in their Facebook photos predict future life satisfaction? In two longitudinal studies, the authors showed that smile intensity coded from a single Facebook profile photograph from male and female participants’ first semester at college was a robust predictor of self-reported life satisfaction 3.5 years later—as they were about to graduate from college. Controlling for first-semester life satisfaction, the authors also determined that smile intensity was a unique predictor of changes in life satisfaction over time. In addition, the authors demonstrated that the results were not due to extraversion or to sex differences in smile intensity. Finally, the authors showed that participants who exhibited a more intense smile in their Facebook photo had better social relationships during their first semester at college and that the association between smile intensity and life satisfaction 3.5 years later was partially mediated by first-semester social relationships satisfaction.
Rural masculinities and fathering practices

Fatherhood and fathering practices have been surprisingly absent from the literature on rural men and masculinity. This article draws on interviews with two generations of farm fathers in Norway to examine how rural masculinities are constructed through fathering practices. It explores how fathering creates potential for the development of alternative rural masculinities in two socio-historical contexts. Findings demonstrate that farm work is important for masculine legitimization in both generations, but, in contrast to the older generation, for the current generation farm work and fathering practices have become spatially separated. Their greater involvement in childcare within the domestic spaces indicates a slight shift towards more equal co-parenting driven by the movement of mothers into the non-farm labour force and the new fathering moralities in society. However, fathering practices through outdoor sports, wilderness activities and hunting constitute stable sites of rural masculinity. As fathering requires nurture and compassion, these ‘traditional’ rural activities display the fluidity of rural masculinity.