Miracle-dz/UniFAR-FTUs huggingface dataset:
Perturbation Centrality and Turbine: A Novel Centrality Measure Obtained Using a Versatile Network Dynamics Tool

Analysis of network dynamics became a focal point to understand and predict changes of complex systems. Here we introduce Turbine, a generic framework enabling fast simulation of any algorithmically definable dynamics on very large networks. Using a perturbation transmission model inspired by communicating vessels, we define a novel centrality measure: perturbation centrality. Hubs and inter-modular nodes proved to be highly efficient in perturbation propagation. High perturbation centrality nodes of the Met-tRNA synthetase protein structure network were identified as amino acids involved in intra-protein communication by earlier studies. Changes in perturbation centralities of yeast interactome nodes upon various stresses well recapitulated the functional changes of stressed yeast cells. The novelty and usefulness of perturbation centrality was validated in several other model, biological and social networks. The Turbine software and the perturbation centrality measure may provide a large variety of novel options to assess signaling, drug action, environmental and social interventions.
Speed and accuracy of visual image discrimination by rats

The trade-off between speed and accuracy of sensory discrimination has most often been studied using sensory stimuli that evolve over time, such as random dot motion discrimination tasks. We previously reported that when rats perform motion discrimination, correct trials have longer reaction times than errors, accuracy increases with reaction time, and reaction time increases with stimulus ambiguity. In such experiments, new sensory information is continually presented, which could partly explain interactions between reaction time and accuracy. The present study shows that a changing physical stimulus is not essential to those findings. Freely behaving rats were trained to discriminate between two static visual images in a self-paced, two-alternative forced-choice reaction time task. Each trial was initiated by the rat, and the two images were presented simultaneously and persisted until the rat responded, with no time limit. Reaction times were longer in correct trials than in error trials, and accuracy increased with reaction time, comparable to results previously reported for rats performing motion discrimination. In the motion task, coherence has been used to vary discrimination difficulty. Here morphs between the previously learned images were used to parametrically vary the image similarity. In randomly interleaved trials, rats took more time on average to respond in trials in which they had to discriminate more similar stimuli. For both the motion and image tasks, the dependence of reaction time on ambiguity is weak, as if rats prioritized speed over accuracy. Therefore we asked whether rats can change the priority of speed and accuracy adaptively in response to a change in reward contingencies. For two rats, the penalty delay was increased from 2 to 6 s. When the penalty was longer, reaction times increased, and accuracy improved. This demonstrates that rats can flexibly adjust their behavioral strategy in response to the cost of errors.
Effect of the coaches' leadership style perceived by athletes on team cohesion among elite Brazilian futsal players

This study investigated the effect of the coach leadership style as perceived by athletes on team cohesion among elite futsal athletes. Participants were 120 athletes from the top-8 teams participating in the Parana’s state Professional League 2013. Instruments used were the Leadership in Sport Scale and the Group Environment Questionnaire. For data analysis, Confirmatory Factor Analysis and Structural Equation Modelling were conducted, as well as Latent Profile Analysis. Results showed significant relationships between leadership style and both social (10%) and task cohesion (31%); in addition, the coach leadership style perceived by athletes characterized as democratic and based on social support, reinforcement and training-instruction influenced positively task cohesion (FL=0.55) and moderately social cohesion (FL=0.31). It is concluded that, for the futsal from the state of Parana, the coach’s leadership style based on democratic, reinforcement, social support and training-instruction behaviours is determinant to the development of task cohesion, however, does not have the same strong influence in social cohesion.
Moral Reasoning: Hints and Allegations

Recent research in moral psychology highlights the role of emotion and intuition in moral judgment. In the wake of these findings, the role and significance of moral reasoning remain uncertain. In this article, we distinguish among different kinds of moral reasoning and review evidence suggesting that at least some kinds of moral reasoning play significant roles in moral judgment, including roles in abandoning moral intuitions in the absence of justifying reasons, applying both deontological and utilitarian moral principles, and counteracting automatic tendencies toward bias that would otherwise dominate behavior. We argue that little is known about the psychology of moral reasoning and that it may yet prove to be a potent social force.
Querying big data

The term "Big Data" became a buzzword and is widely used in both research and industrial worlds. Typically the concept of big data assumes a variety of different sources of information and velocity of complex analytical processing, rather than just a huge and growing volume of data. All variety, velocity, and volume create new research challenges, as nearly all techniques and tools commonly used in data processing have to be re-considered. Variety and uncertainty of big data require a mixture of exact and similarity search and grouping of complex objects based on different attributes. High-level declarative query languages are important in this context due to expressiveness and potential for optimization. In this talk we are mostly interested in an algebraic layer for complex query processing which resides between user interface (most likely, graphical) and execution engine in layered system architecture. We analyze the applicability of existing models and query languages. We describe a systematic approach to similarity handling of complex objects, simultaneous application of different similarity measures and querying paradigms, complex searching and querying, combined semi-structured and unstructured search. We introduce the adaptive abstract operations based on the concept of fuzzy set, which are needed to support uniform handling of different kinds of similarity processing. To ensure an efficient implementation, approximate algorithms with controlled quality are required to enable quality versus performance trade-off for timeliness of similarity processing. Uniform and adaptive operations enable high-level declarative definition of complex queries and provide options for optimization.
Corporate Governance and Corporate Failure: a Survival Analysis

Past studies show that weak corporate governance tends to reduce corporate value by employing a variety of prediction methodologies and models including multivariate discriminant analysis, probit and logit analysis and artificial neural networks, whether it will lead to a higher survival probability of a distressed company remains an open question. Within this framework, we aim to estimate the probability of corporate survival to a specified time from 2005 to mid-2011 for 56 financially distressed firms using survival analysis technique. We will use the Cox proportional hazard form to assess the usefulness of corporate governance and financial variables as predictors of the probability of company endurance to a given time. Results show that the delisting of PN17 companies has a significant negative relationship with managerial ownership and positive relationship with size of the company. Results imply that in Malaysia delisted companies are bigger and have lesser managerial ownership than those remain as PN17. In other word, higher managerial ownership helps reduce the risk of failing while larger companies contribute to higher risk of failing. However, this study is unable to obtain evidence on the relationships between other corporate governance and financial variables with the survival likelihood of financially distressed companies.
Intrinsic Bioenergetic Properties and Stress Sensitivity of Dopaminergic Synaptosomes

Dopaminergic neurons of the substantia nigra pars compacta are defective in Parkinson's disease, but the specificity of this dysfunction is not understood. One hypothesis is that mitochondrial bioenergetic capacity is intrinsically lower in striatal dopaminergic presynaptic nerve varicosities, making them unusually susceptible to inhibition of electron transport by oxidative damage. To test this hypothesis, we separated isolated synaptosomes bearing dopamine transporters using immunomagnetic beads and compared their respiration with that of the residual nondopaminergic synaptosomes. As predicted, dopaminergic synaptosomes from striatum had lower respiratory rates. However, so did dopaminergic synaptosomes from cortex, indicating a lack of the predicted striatal specificity. We used fluorescent probes to analyze the bioenergetic competence of individual synaptosomes in the two fractions. The respiratory differences became nonsignificant when respiration rates were normalized to the number of respiration-competent synaptosomes, suggesting that differences reflected the quality of the different fractions. To circumvent damage induced by synaptosomal separation, we monitored membrane potentials in whole unseparated single synaptosomes using fluorescent imaging, and then identified the dopaminergic subpopulation using a fluorescent dopamine transporter substrate (ASP+ [4-(4-diethylaminostyryl)-N-methylpyridinium iodide]). The capacity of dopaminergic and nondopaminergic synaptosomes to maintain plasma membrane and mitochondrial membrane potential under several stresses did not differ. In addition, this capacity did not decline in either subpopulation with age, a risk factor for Parkinson's disease. We conclude that the intrinsic bioenergetic capacities of dopaminergic and nondopaminergic presynaptic synaptosomes from mice do not differ.
Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture

Efficient ex vivo expansion of hematopoietic stem cells with a concomitant preservation of stemness and self-renewal potential is still an unresolved ambition. Increased numbers of methods approaching this issue using three-dimensional (3D) cultures were reported. Here, we describe a simplified 3D hanging drop model for the coculture of cord blood-derived CD34+ hematopoietic stem and progenitor cells (HSPCs) with bone marrow-derived mesenchymal stromal cells (MSCs). When seeded as a mixed cell suspension, MSCs segregated into tight spheroids. Despite the high expression of niche-specific extracellular matrix components by spheroid-forming MSCs, HSPCs did not migrate into the spheroids in the initial phase of coculture, indicating strong homotypic interactions of MSCs. After one week, however, HSPC attachment increased considerably, leading to spheroid collapse as demonstrated by electron microscopy and immunofluorescence staining. In terms of HSPC proliferation, the conventional 2D coculture system was superior to the hanging drop model. Furthermore, expansion of primitive hematopoietic progenitors was more favored in 2D than in 3D, as analyzed in colony-forming assays. Conclusively, our data demonstrate that MSCs, when arranged with a spread (monolayer) shape, exhibit better HSPC supportive qualities than spheroid-forming MSCs. Therefore, 3D systems are not necessarily superior to traditional 2D culture in this regard.
Fin De Siecle Real Interest Parity

We evaluate the recent evidence for real interest parity, focusing on long-term yields. Examining the data on financial instruments of various maturities across the G7 countries, we find substantial differences in the degree of real interest equalization measured at different horizons. In general, real interest parity holds better at long horizons than at short. This empirical result is robust to alternative ways of modeling expected inflation rates. Considering the relevance of long-term yields for the investment decisions of firms, our findings imply that the degree of capital mobility among the G-7 economies may be greater than previously thought.
Exploitation-Exploration Tensions and Organizational Ambidexterity: Managing Paradoxes of Innovation

Achieving exploitation and exploration enables success, even survival, but raises challenging tensions. Ambidextrous organizations excel at exploiting existing products to enable incremental innovation and at exploring new opportunities to foster more radical innovation, yet related research is limited. Largely conceptual, anecdotal, or single case studies offer architectural or contextual approaches. Architectural ambidexterity proposes dual structures and strategies to differentiate efforts, focusing actors on one or the other form of innovation. In contrast, contextual approaches use behavioral and social means to integrate exploitation and exploration. To develop a more comprehensive model, we sought to learn from five, ambidextrous firms that lead the product design industry. Results offer an alternative framework for examining exploitation-exploration tensions and their management. More specifically, we present nested paradoxes of innovation: strategic intent (profit-breakthroughs), customer orientation (tight-loose coupling), and personal drivers (discipline-passion). Building from innovation and paradox literature, we theorize how integration and differentiation tactics help manage these interwoven paradoxes and fuel virtuous cycles of ambidexterity. Further, managing paradoxes becomes a shared responsibility, not only of top management, but across organizational levels.
Comprehensive analysis of the functional microRNA–mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression

Glioma is the most common and fatal primary brain tumour with poor prognosis; however, the functional roles of miRNAs in glioma malignant progression are insufficiently understood. Here, we used an integrated approach to identify miRNA functional targets during glioma malignant progression by combining the paired expression profiles of miRNAs and mRNAs across 160 Chinese glioma patients, and further constructed the functional miRNA–mRNA regulatory network. As a result, most tumour-suppressive miRNAs in glioma progression were newly discovered, whose functions were widely involved in gliomagenesis. Moreover, three miRNA signatures, with different combinations of hub miRNAs (regulations≥30) were constructed, which could independently predict the survival of patients with all gliomas, high-grade glioma and glioblastoma. Our network-based method increased the ability to identify the prognostic biomarkers, when compared with the traditional method and random conditions. Hsa-miR-524-5p and hsa-miR-628-5p, shared by these three signatures, acted as protective factors and their expression decreased gradually during glioma progression. Functional analysis of these miRNA signatures highlighted their critical roles in cell cycle and cell proliferation in glioblastoma malignant progression, especially hsa-miR-524-5p and hsa-miR-628-5p exhibited dominant regulatory activities. Therefore, network-based biomarkers are expected to be more effective and provide deep insights into the molecular mechanism of glioma malignant progression.
Cyclooxygenase-2 overexpression, using an integrin-targeted gene delivery system (the LID vector), inhibits fibroblast proliferation in vitro and leads to increased prostaglandin E(2) in the lung.

Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter. Safety of single-dose administration of an adeno-associated virus (AAV)-CFTR vector in the primate lung. A phase I study of an adeno-associated virus-CFTR gene vector in adult CF patients with mild lung disease. A phase I/II study of tgAAV-CF for the treatment of chronic sinusitis in patients with cystic fibrosis. A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in CF patients with antrostomies. 2002 (in press) 15 Wagner JA, Reynolds T, Moran ML, et al. Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus [letter]. Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis trans-membrane conductance regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus. Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors. A fluorescence video-endoscopy technique for detection of gene transfer and expression. Latent adeno-associated virus infection elicits humoral but not cell-mediated immune responses in a nonhuman primate model. et al. Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line. et al. Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. recombinant adeno-associated virus (rAAV) transduction by bronchial secretions from cystic fibrosis patients. Gene Ther 2000; 7:1783–1789 27 Summerford C, Samulski RJ. Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. Factors influencing adeno-associated virus-mediated gene transfer to human cystic fibrosis airway epithelial cells: comparison with adeno-virus vectors. Mutational analysis of the adeno-associated virus type2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism.associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer. A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation. Nat Med 2000; 6:595–598 32 Yan Z, Zhang Y, Duan D, et al. From the cover: trans-splicing vectors expand the utility of adeno-associated virus for gene therapy. P ulmonary fibrosis is a progressive and fatal disease for which there is no effective treatment. It is characterized by increased matrix deposition following an apparent, or subclinical, lung injury. The fibrogenic process often is
Time-window sequential analysis: an introduction for pediatric psychologists.

OBJECTIVE Pediatric psychologists are often interested in interactions among individuals (e.g., doctors and patients, parents and children). Most research examining the nature of these interactions has used correlational analyses. Sequential analysis provides greater detail on contingencies during interactions and the way that interactions play out over time. The purpose of this article is to offer a non-technical introduction to sequential analyses for pediatric psychologists. METHODS A more recent derivation of the basic method, called time-window sequential analysis, is introduced and distinguished from other forms of sequential analysis. RESULTS A step-by-step pediatric psychology example of time-window sequential analysis is provided and the integration of sequential analysis with traditional statistical methods is discussed. An example of physician-child interaction during anesthesia induction is used to illustrate the technique. CONCLUSION Sequential analysis is a technique that is useful to pediatric psychologists who are interested in contingencies among data collected over time.
A Cross-Sectional Analytic Study of Postpartum Health Care Service Utilization in the Philippines

Background The maternal mortality ratio in the Philippines remains high; thus, it will be difficult to achieve the Millennium Development Goals 5 by 2015. Approximately two-thirds of all maternal deaths occur during the postpartum period. Therefore, we conducted the present study to examine the current state of postpartum health care service utilization in the Philippines, and identify challenges to accessing postpartum care. Methods A questionnaire and knowledge test were distributed to postpartum women in the Philippines. The questionnaire collected demographical characteristics and information about their utilization of health care services during pregnancy and the postpartum period. The knowledge test consisted of 11 questions regarding 6 topics related to possible physical and mental symptoms after delivery. Sixty-four questionnaires and knowledge tests were analyzed. Results The mean time of first postpartum health care visit was 5.1±5.2 days after delivery. Postpartum utilization of health care services was significantly correlated with delivery location (P<0.01). Women who delivered at home had a lower rate of postpartum health care service utilization than women who delivered at medical facilities. The majority of participants scored low on the knowledge test. Conclusion We found inadequate postpartum health care service utilization, especially for women who delivered at home. Our results also suggest that postpartum women lack knowledge about postpartum health concerns. In the Philippines, Barangay health workers may play a role in educating postpartum women regarding health care service utilization to improve their knowledge of possible concerns and their overall utilization of health care services.
European Journal of Education Studies-ISSN 2501-1111

Individuals’ perceptions of parental roles is a significant aspect of their parenting and one's appraisal of parental roles might be related to their global appraisal of marriage. Therefore in this study, it was aimed to examine the relationship between self perception of parental role and marital attitude. The participants of the study are comprised of 220 females and males. In order to gather socio-demographic information, the parents were administered an “Individual Information Form”. In order to assess participants’ self-perception of parental roles Self-Perception of Parental Role Scale, and in order to assess marital attitudes of the participants Marital Attitude Scale (MAS), were administered. As a result, it was found that there are significantly positive correlations (p<0.05) between the scores of the competence and role balance subdimensions of SPPR and the scores of MAS, whereas there are no significant correlations (p>0.05) between the scores of the role satisfaction and investment subdimensions of SPPR and the scores of MAS. The findings are discussed in terms of the relevant literature.
A model of paternal protection in the context of political violence: Insights from the occupied Palestinian territories

There is little research that explores how fathers protect their children in the context of political violence. Drawing upon exploratory qualitative research with 18 Palestinian families, this article proposes a model of paternal protection composed of three dimensions: (1) method of protection (how fathers protect their children), (2) focus of protection (what fathers protect their children from), and (3) locus of protection (where fathers locate the mechanisms of protection). The model contributes to a greater awareness and understanding of the daily challenges facing fathers and suggests ways that social work practice and policy can support fathers in settings of adversity.