Miracle-dz/UniFAR-FTUs huggingface dataset:
Mariposas diurnas (Lepidoptera: Papilionoidea y Hesperioidea) de la reserva privada Osununú-parque provincial Teyú Cuaré y alrededores de San Ignacio, provincia de Misiones, Argentina.

During nine field trips from December 2008 to September 2010, 357 species of butterflies were found at Argentina's Teyu Cuare Provincial Park and Osununu private reserve, in the Interior Atlantic Forest biome. A list of these species is presented here, representing the first list of Lepidoptera from southern Misiones. A number of species typical of Brazilian and Paraguayan cerrado vegetation, such as Eurytides dolicaon deicoon, Aricoris aff. colchis and Cogia hassan evansi , were found in this study. This suggests a possible movement of these species from northern latitudes through gallery forests along the Parana river. The species Napaea eucharila (Bates, 1867) and Pompeius dares (Plotz, 1883) are new records for the country. Additional species should eventually be recorded, especially within grassland on the outskirts of Osununu reserve, when we expand our sampling efforts to other times throughout the year. Durante nueve viajes de campo realizados entre Diciembre 2008 y Septiembre 2010 se registraron 357 especies de mariposas en el Parque Provincial Teyu Cuare y la reserva privada Osununu (Argentina), correspondientes al bioma Bosque Atlantico Interior. El listado de tales especies se presenta aqui, siendo el primer listado de Lepidoptera del sector sur de Misiones. Varias especies tipicas del cerrado Brasilero y Paraguayo, tales como Eurytides dolicaon deicoon, Aricoris aff. colchis y Cogia hassan evansi , fueron encontradas en el presente estudio, lo cual sugiere un posible movimiento de estas especies desde latitudes nortenas a traves de bosques de galeria a lo largo del rio Parana. Las especies Napaea eucharila (Bates, 1867) y Pompeius dares (Plotz, 1883) son nuevos registros para el pais. Especies adicionales seran registradas eventualmente, especialmente en el area de pastizales localizada en los alrededores de la reserva privada Osununu, ya que hubo varios meses en que no se visito la zona.
Novel Vascular Molecule Involved in Monocyte Adhesion to Aortic Endothelium in Models of Atherogenesis

Adhesion of monocytes to the endothelium in lesion-prone areas is one of the earliest events in fatty streak formation leading to atherogenesis. The molecular basis of increased monocyte adhesion is not fully characterized. We have identified a novel vascular monocyte adhesion-associated protein, VMAP-1, that plays a role in adhesion of monocytes to activated endothelium. Originally selected for its ability to block binding of a mouse monocyte-like cell line (WEHI78/24) to cytokine- or LPS-stimulated cultured mouse endothelial cells in vitro, antiVMAP-1 mAb LM151 cross-reacts with rabbit endothelium and blocks binding of human monocytes to cultured rabbit aortic endothelial cells stimulated with minimally modified low density lipoprotein, thought to be a physiologically relevant atherogenic stimulus. Most importantly, LM151 prevents adhesion of normal monocytes and monocytoid cells to intact aortic endothelium from cholesterol-fed rabbits in an ex vivo assay. VMAP-1 is a 50-kD protein. Immunohistology of vessels reveals focal constitutive expression in aorta and other large vessels. VMAP-1 is thus a novel vascular adhesion-associated protein that appears to play a critical role in monocyte adhesion to aortic endothelial cells in atherogenesis in vivo.
Networked-based generalised H∞ fault detection filtering for sensor faults

This paper is concerned with designing fault detection filters for networked control systems subject to limited communication capacity and a class of sensor stuck faults. By taking into account the communication limitations (e.g. measurement quantisation, signal transmission delays and data packet dropouts) and all possible sensor stuck faults, a unified mathematical model is first presented. Based on this framework, a full-order fault detection filter is designed such that the residual system is asymptotically stable with the prescribed attenuation level in the generalised H∞ sense. In order to further improve the detection performance, an optimisation algorithm is proposed to minimise the threshold. Finally, a spring-mass-damper system is utilised to show the effectiveness of the proposed method.
Factor analysis based VTS and JUD noise estimation and compensation

Model based compensation schemes are a powerful approach for noise robust speech recognition. Recently there have been a number of investigations into adaptive training, and estimating the noise models used for model adaptation. This paper examines the use of EM-based schemes for both canonical models and noise estimation, including discriminative adaptive training. One issue that arises when estimating the noise model is a mismatch between the noise estimation approximation and final model compensation scheme. This paper proposes FA-style compensation where this mismatch is eliminated, though at the expense of a sensitivity to the initial noise estimates. EM-based discriminative adaptive training is evaluated on in-car and Aurora4 tasks. FA-style compensation is then evaluated in an incremental mode on the in-car task.
Personality Disorders among Danish Alcoholics Attending Outpatient Treatment

The aim of the present study was firstly to describe the characteristics of alcoholic outpatients (A) suffering from co-morbid personality disorder (PD) of either the cluster B (A+PDB) or cluster C (A+PDC) type. Secondly, to investigate the effect of various kinds of treatment to be able to single out the most beneficial therapy. Thirdly, to identify the most beneficial treatment. The patients were offered the following outpatient treatments: cognitive behaviour therapy, family therapy and supportive consultations. The material consisted of 363 patients who started psychosocial treatment at the outpatient alcohol clinic at Odense University Hospital, Denmark. It was possible to re-interview 276 (76%) patients 1 year after onset of treatment. Of the 363 patients, 87% were alcohol-dependent (ICD-10) and 34% fulfilled the ICD-10-R criteria for PDs. The basic interviews focused on the seven main areas of the Addiction Severity Index. A+PDC had significantly more serious medical problems than A–PD, while the A+PDB group had significantly more employment, drug use and social problems than the A–PD. As for psychiatric status, A–PD had significantly different scores compared with A+PDB and A+PDC. A+PDB were younger and had a longer history of alcohol abuse than A–PD and A+PDC. After treatment there was no significance between the patients with and without PD concerning alcohol outcome and psychosocial outcome. The significance of co-morbid PD for the prognosis of alcohol abusers may be overestimated. Our results indicate that A+PD can be treated as successfully as other patients in an outpatient alcohol clinic can.
Symptom Clusters and Quality of Life in Subjects With COPD

BACKGROUND: COPD is one of the most common respiratory diseases. Patients with COPD experience and suffer from various physical and psychological symptoms. We performed this study to identify symptom clusters and the effects on quality of life (QOL) in patients with COPD. METHODS: A total of 130 COPD subjects were recruited from a university hospital in South Korea. Dyspnea, fatigue, depression, anxiety, sleep disturbance, dry mouth, and physical functional status were assessed with structured questionnaires. QOL was measured with the Clinical COPD Questionnaire. Factor analysis and cluster analysis were used to identify symptom clusters based on severity of symptom experiences. RESULTS: Three distinct clusters were identified: a respiratory-functional cluster (symptom cluster 1), a mood cluster (symptom cluster 2), and a fatigue-sleep cluster (symptom cluster 3). Symptom cluster 1 consisted of dyspnea, physical functional status, and dry mouth; symptom cluster 2 consisted of anxiety and depression; and symptom cluster 3 consisted of sleep disturbance and fatigue. Subgroup cluster analysis showed that COPD subjects with higher-scoring symptoms in symptom clusters 1, 2, and 3 had significantly poorer QOL. The symptom clusters were significantly different depending on age, educational level, and monthly income. CONCLUSIONS: COPD subjects may have specific patterns of symptom clusters. The symptom clusters are related with clinical characteristics and had a negative impact on QOL. To enhance symptom management and QOL, approaches and interventions based on symptom clusters, rather than independent intervention for each symptom, may be more effective. Understanding COPD symptom clusters may help successful symptom management, which can improve QOL for COPD patients.
Fine Mapping and SNP Analysis of Positional Candidates at the Preeclampsia Susceptibility Locus (PREG1) on Chromosome 2

Genome scans in Icelandic, Australian and New Zealand, and Finnish families have localized putative susceptibility loci for preeclampsia/eclampsia to chromosome 2. The locus mapped in the Australian and New Zealand study (designated PREG1) was thought to be the same locus as that identified in the Icelandic study. In both these studies, two distinct quantitative trait locus (QTL) regions were evident on chromosome 2. Here, we describe our fine mapping of the PREG1 locus and a genetic analysis of two positional candidate genes. Twenty-five additional microsatellite markers were genotyped within the 74-cM linkage region defined by the combined Icelandic and Australian and New Zealand genome scans. The overall position and shape of the localization evidence obtained using nonparametric multipoint analysis did not change from that seen previously in our 10-cM resolution genome scan; two peaks were displayed, one on chromosome 2p at marker D2S388 (107.46 cM) and the other on chromosome 2q at 151.5 cM at marker D2S2313. Using the robust two-point linkage analysis implemented in the Analyze program, all 25 markers gave positive LOD scores with significant evidence of linkage being seen at marker D2S2313 (151.5 cM), achieving a LOD score of 3.37 under a strict diagnostic model. Suggestive evidence of linkage was seen at marker D2S388 (107.46 cM) with a LOD score of 2.22 under the general diagnostic model. Two candidate genes beneath the peak on chromosome 2p were selected for further analysis using public single nucleotide polymorphisms (SNPs) within these genes. Maximum LOD scores were obtained for an SNP in TACR1 (LOD = 3.5) and for an SNP in TCF7L1 (LOD = 3.33), both achieving genome-wide significance. However, no evidence of association was seen with any of the markers tested. These data strongly support the presence of a susceptibility gene on chromosome 2p11–12 and substantiate the possibility of a second locus on chromosome 2q23.
Congenital and acquired pulmonary vein stenosis.

Pulmonary vein stenosis is a fascinating yet frustrating and difficult to manage condition with an exceptionally high mortality rate. Until recently, the disease was seen almost exclusively in young children with or without various forms of congenital heart disease. Pulmonary vein stenosis is a relatively rare condition. In most published series from large centers, there has been an average of ≈2 or 3 cases per year that require treatment. Pulmonary vein stenosis in the adult population is even more rare, and the small number of reported cases has often been associated with mediastinal processes such as neoplasms or fibrosing mediastinitis. However, with the advent of aggressive treatment strategies for atrial fibrillation, we have seen a new group of pulmonary vein stenosis patients. The stenosis appears as a complication of radiofrequency ablation procedures around the pulmonary veins. Small series of new surgical and interventional catheterization procedures for treatment of both the pediatric and adult forms of pulmonary vein stenosis suggest an improving prognosis in centers with specialized expertise. However, the prognosis of patients affected with pulmonary vein stenosis remains guarded and requires diligent follow-up and often repeated procedures. The purpose of this article is to review concepts of causation and possible treatments for this rare but serious condition as they evolve. The left atrium and pulmonary veins initially develop separately in the 3- to 5-mm embryo (25 to 27 days gestation). 1 The primordial pulmonary venous system is part of the splanchnic plexus, which initially connects to the cardinal and umbilicovitelline veins. At 27 to 29 days gestation, a small endothelial outgrowth from the posterior superior wall of the primordial left atrium develops just to the left of the developing septum primum. At 28 to 30 days gestation, this common pulmonary venous out-pouching engages the pulmonary venous portion of the splanchnic …
Hepatitis B infection of the liver in chronic hepatitis C without detectable hepatitis B virus DNA in serum

Hepatitis B virus (HBV) DNA may persist in the liver in the absence of serum HBV–DNA after a self‐limited acute hepatitis B. This may also occur in patients with chronic hepatitis C virus (HCV) infection but its prevalence and its impact on liver histology is unknown. HBV–DNA was tested by polymerase chain reaction (PCR) and by in situ hybridisation in liver biopsies from 98 patients with chronic hepatitis C who were hepatitis B surface antigen negative and serum HBV–DNA negative by PCR. HBV–DNA resulted positive in the liver of 37/98 (37.7%) patients without serum HBV–DNA. To test whether these patients had serum HBV–DNA levels under the detection limit of the PCR assay used in this study (50 copies/ml), PCR products in which HBV–DNA was undetectable after visualization of agarose gels were analysed by dot‐blot hybridisation. With this method, HBV–DNA was positive in serum of 12/37 patients with liver HBV–DNA. Thus, 25/98 (25.5%) patients have HBV–DNA detectable only in liver. This was confirmed by in situ hybridisation, the percentage of infected hepatocytes ranging from 0.1% to 12%. In patients in whom the HCV infection was shorter than 20 years, HBV infected patients had higher (P = 0.01) fibrosis score (1.64 ± 1.21) than HBV negative cases (0.53 ± 0.66). In conclusion, a significant proportion of patients with chronic HCV infection have HBV–DNA in the liver in the absence of viral DNA in serum. The impact of this finding on liver histology deserves further research. J. Med. Virol. 73:177–186, 2004. © 2004 Wiley‐Liss, Inc.
TRPC1, CaN and NFATC3 signaling pathway in the pathogenesis and progression of left ventricular hypertrophy in spontaneously hypertensive rats

Abstract Spontaneously hypertensive rats (SHR) was used to study left ventricular hypertrophy (LVH) and its dynamic change after the interventions with Telmisartan and Amlodipine. The results showed that the expression of TRPC1, CaN and NFATC3 increased gradually with the pathogenesis and progression of LVH. Telmisartan reduced blood pressure and LVH, and down-regulated the expression of TRPC1, CaN and NFATC3 in left ventricle of SHR. Amlodipine reduced the blood pressure in SHR but had no impact on the hypertrophy and expression of above factors. Our data suggest that the pathogenesis and progression of LVH in SHR are related to upregulation of TRPC1, CaN and NFATC3 signaling pathway.
LimTox: a web tool for applied text mining of adverse event and toxicity associations of compounds, drugs and genes

Abstract A considerable effort has been devoted to retrieve systematically information for genes and proteins as well as relationships between them. Despite the importance of chemical compounds and drugs as a central bio-entity in pharmacological and biological research, only a limited number of freely available chemical text-mining/search engine technologies are currently accessible. Here we present LimTox (Literature Mining for Toxicology), a web-based online biomedical search tool with special focus on adverse hepatobiliary reactions. It integrates a range of text mining, named entity recognition and information extraction components. LimTox relies on machine-learning, rule-based, pattern-based and term lookup strategies. This system processes scientific abstracts, a set of full text articles and medical agency assessment reports. Although the main focus of LimTox is on adverse liver events, it enables also basic searches for other organ level toxicity associations (nephrotoxicity, cardiotoxicity, thyrotoxicity and phospholipidosis). This tool supports specialized search queries for: chemical compounds/drugs, genes (with additional emphasis on key enzymes in drug metabolism, namely P450 cytochromes—CYPs) and biochemical liver markers. The LimTox website is free and open to all users and there is no login requirement. LimTox can be accessed at: http://limtox.bioinfo. cnio.es
Activity based financing in England: the need for continual refinement of payment by results

Abstract The English National Health Service is introducing activity based tariff systems or Payment by Results (PbR) as the basis for hospital funding. The funding arrangements provide incentives for increasing activity, particularly day surgery, and, uniquely, are based on costing data from all hospitals. But prices should not be based on average costs and the potential of PbR to improve the quality of care is yet to be exploited. Without refinement, PbR threatens to undermine expenditure control, to divert resources away from primary care, and to distort needs based funding.
Smoking and adolescence: narratives of identity.

The purpose of this study was to understand the identities that youth hold in relation to smoking, as revealed in narrative accounts of their smoking experiences. The analysis was a narrative inquiry, a qualitative approach based on the propensity of people to narrate or tell stories about the experiences in their daily lives. A purposeful sample of 35 youths ages 14-18 years with a variety of smoking histories (all had tried smoking) participated in in-depth interviews. A detailed analysis of the transcripts revealed the key identities communicated by the youths including the confident nonsmoker, the vulnerable nonsmoker, the ardent nonsmoker, the accepting nonsmoker, the in-control smoker, the confirmed smoker, and the contrite smoker. Tobacco control interventions for youth must be designed to respond to and incorporate multiple smoking identities.
Action Tubelet Detector for Spatio-Temporal Action Localization

Current state-of-the-art approaches for spatio-temporal action localization rely on detections at the frame level that are then linked or tracked across time. In this paper, we leverage the temporal continuity of videos instead of operating at the frame level. We propose the ACtion Tubelet detector (ACT-detector) that takes as input a sequence of frames and outputs tubelets, i.e., sequences of bounding boxes with associated scores. The same way state-of-the-art object detectors rely on anchor boxes, our ACT-detector is based on anchor cuboids. We build upon the SSD framework [19]. Convolutional features are extracted for each frame, while scores and regressions are based on the temporal stacking of these features, thus exploiting information from a sequence. Our experimental results show that leveraging sequences offrantes significantly improves detection performance over using individual frames. The gain of our tubelet detector can be explained by both more accurate scores and more precise localization. Our ACT-detector outperforms the state-of-the-art methods for frame-mAP and video-mAP on the J-HMDB [12] and UCF-101 [31] datasets, in particular at high overlap thresholds.
Shadow Detection in Remotely Sensed Images Based on Self-Adaptive Feature Selection

Shadows in remotely sensed images create difficulties in many applications; thus, they should be effectively detected prior to further processing. This paper presents a novel semiautomatic shadow detection method that meets the requirements of both high accuracy and wide practicability in remote sensing applications. The proposed method uses only the properties derived from the shadow samples to dynamically generate a feature space and calculate decision parameters; then, it employs a series of transformations to separate shadow and nonshadow regions. The proposed method can detect shadows from both color and gray images. If the chromatic properties of color images do not agree with the defined rules through the shadow samples, then the shadow detection process will automatically reduce to the process for gray images. As the shadow samples are manually selected from the input image by the user, the derived parameters conform well to the characteristics of the input image. Experiments and comparisons indicate that the proposed self-adaptive feature selection algorithm is accurate, effective, and widely applicable to shadow detection in practical applications.
Vascular Access Site for Renal Replacement Therapy in Acute Kidney Injury: A Post hoc Analysis of the ATN Study

Background Acute kidney injury requiring renal replacement therapy (RRT) in the intensive care unit portends a poor prognosis. The decisions regarding dialysis catheter placement is based mainly on physician discretion with little evidence to support the choice of dialysis catheter location. Methods The Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study was a multicenter, prospective, randomized trial of intensive vs. less intensive RRT in critically ill patients with AKI. We assessed the association of dialysis catheter location with dialysis catheter-related outcomes including catheter-related complications, mortality, dialysis dependence, and dialysis dose delivered. Results Of the 1,124 patients enrolled in the ATN study, catheter data were available in 1,016 (90.39%) patients. A total of 91 (8.96%) subclavian, 387 (38.09%) internal jugular, and 538 (52.95%) femoral dialysis catheters were inserted. The femoral group was younger (58.39 ± 16.27), had greater bleeding tendency [lower platelet count (96.00 ± 109.35) with higher INR (2.01 ± 2.19)], and had a higher baseline sequential organ failure assessment score on admission (14.59 ± 3.61) compared to the other two groups. Dialysis catheter-related complications were low in this study with no significant difference in the rates of complications among all catheter locations. Mortality and dialysis dependence was lowest in the subclavian group, while the dose of dialysis delivered (Kt/V) remained lowest in the femoral group, after propensity score and center adjustments. Conclusion Patient characteristics influence the choice of dialysis catheter location with a tendency to place femoral catheters in younger, sicker, and more coagulopathic patients. There were no statistically significant differences in complication rates among the three catheter locations, although femoral catheters may be associated with a lower delivered dose of dialysis during intermittent hemodialysis. Clinical Trial Registration www.ClinicalTrials. gov, identifier NCT00076219.