Miracle-dz/UniFAR-FTUs huggingface dataset:
Self‐worth Protection: review and implications for the classroom

The present article focuses on self‐worth protection and its prevention and modification in the classroom. This is a term given to voluntary self‐handicapping behaviours adopted by certain students in achievement situations which forebode failure and thereby, damage to self‐esteem. Withdrawal of effort, prevarication, low goal setting and last minute study are examples of such behaviours. While such behaviours protect a sense of self‐worth in the short term, the enduring consequence is underachievement. The genesis of the self‐handicapping behaviours of self‐worth protective students is traced to the effects of noncontingent feedback and to individual difference variables which render them particularly vulnerable to such effects. Strategies to enhance the achievement of self‐worth protective students thus take account of sources of noncontingent feedback in teachers’ use of evaluative feedback. Effective use of praise which is informational rather than directive of future performance, is advised. The impo.
Biodegradable pressure sensor for health-care

The subject of the present work is the design, the testing and the implementation of a biodegradable and biocompatible pressure sensor that can be swallowed or implanted in the human body. It has to be biodegradable, at least in part, biocompatible and small in the size. The biodegradable polymer used (Polycaprolactone, PCL) and the technique of printing gold (200-400 nm thick) on it have played a key role throughout the project. PCL was used both as substrate, on which all connections for discrete surface mount devices were printed, and for fabricating the pressure sensitive devices. A possible implementation for gastroenterology is presented. The final implementation fully satisfies the design specifications of biodegradability and biocompatibility, high operating frequency, high frequency sensitivity to changes in capacitance and size minimization.
Premotor functional connectivity predicts impulsivity in juvenile offenders

Teenagers are often impulsive. In some cases this is a phase of normal development; in other cases impulsivity contributes to criminal behavior. Using functional magnetic resonance imaging, we examined resting-state functional connectivity among brain systems and behavioral measures of impulsivity in 107 juveniles incarcerated in a high-security facility. In less-impulsive juveniles and normal controls, motor planning regions were correlated with brain networks associated with spatial attention and executive control. In more-impulsive juveniles, these same regions correlated with the default-mode network, a constellation of brain areas associated with spontaneous, unconstrained, self-referential cognition. The strength of these brain–behavior relationships was sufficient to predict impulsivity scores at the individual level. Our data suggest that increased functional connectivity of motor-planning regions with networks subserving unconstrained, self-referential cognition, rather than those subserving executive control, heightens the predisposition to impulsive behavior in juvenile offenders. To further explore the relationship between impulsivity and neural development, we studied functional connectivity in the same motor-planning regions in 95 typically developing individuals across a wide age span. The change in functional connectivity with age mirrored that of impulsivity: younger subjects tended to exhibit functional connectivity similar to the more-impulsive incarcerated juveniles, whereas older subjects exhibited a less-impulsive pattern. This observation suggests that impulsivity in the offender population is a consequence of a delay in typical development, rather than a distinct abnormality.
L'enseignement des langues vivantes à l'école élémentaire : éléments d'évaluation des effets au collège

Cette recherche est une evaluation des effets de l'enseignement des langues au primaire ; elle est basee sur une enquete longitudinale qui a consiste a suivre pendant deux ans un echantillon de 1 500 eleves entrant au college. Certains de ces eleves avaient beneficie d'un enseignement de l'anglais a l'ecole primaire dans le cadre de l'experimentation mise en place par le ministere de l'Education nationale, alors que d'autres debutaient cet apprentissage au college. D'une part on a decrit l'effet d'un certain nombre de facteurs qui determinent le niveau atteint en anglais par les eleves aux differentes etapes de la scolarite. D'autre part on a mesure l'impact de l'experimentation sur les acquisitions des eleves au college : au final, il s'avere que l'interet de cette experimentation apparait tres limite.
The price of admission: football players' sacrificial conceptions of career and health through metaphors of war, religion, and family

With the recent discovery of traumatic brain injuries developing in retired professional football players, this study seeks to explore players’ perceptions of their careers in the sport, and how this may reflect notions of personal health over the long-term. Current and former football players, athletic staff, and other members of the football community were interviewed with the goal of learning about the full trajectory of a football career. Using grounded metaphorical analysis to examine the interview data, our study found the use of metaphor by participants to be integral in players’ descriptions of their careers. Participants likened aspects of their careers to enduring a war, having a religious experience, and being part of a family unit. Long-term, post-career health implications are discussed in relation to players’ conceiving of their experiences through these metaphors, along with limitations of the study and directions for future research.
A Story of Miscarriage: Law in the Media

This article utilizes the work of the sociologist Niklas Luhmann in order to examine the relationship between law and the media. Luhmann views both law and the media as closed systems of communication, systems which cannot duplicate the meaning of each other's communications. After introducing Luhmann's approach to media reporting, and applying this to the relationship between law and media reporting on law, the article analyses a recent miscarriage of justice case. The case is that of the solicitor Sally Clark who was convicted of a double child killing. Although her first appeal was rejected she succeeded in a second appeal. Media reporting of Sally Clark's case is contrasted with the trial and Court of Appeal judgments to demonstrate the different basis upon which law and the media each construct communications about the same events
Failure of the MicroScan WalkAway System To Detect Heteroresistance to Carbapenems in a Patient with Enterobacter aerogenes Bacteremia

ABSTRACT We report the failure of the automated MicroScan WalkAway system to detect carbapenem heteroresistance in Enterobacter aerogenes. Carbapenem resistance has become an increasing concern in recent years, and robust surveillance is required to prevent dissemination of resistant strains. Reliance on automated systems may delay the detection of emerging resistance.
Characterization of the ETO and AML1–ETO proteins involved in the 8;21 translocation in acute myelogenous leukemia

Abstract: The AML1 and ETO genes are disrupted by the nonrandom chromosomal translocation t(8;21) in acute myelogenous leukemia (AML). While the AML1 gene encodes a transcription factor indispensable for definitive hematopoiesis, the biological function of ETO is unknown. To understand the role of ETO and AML1–ETO in the pathogenesis of AML, the full length cDNAs of ETO and AML1–ETO were cloned and antibodies against AML1 and ETO proteins have been developed in our laboratory. Western blot analysis showed that ETO and AML1–ETO were identified as 70 kDa and 94 kDa proteins, respectively, and that both proteins, like AML1, were associated with the nuclear matrix. To examine whether the t(8;21)‐positive AMLs expressed a 94‐kDa AML1–ETO, protein fractions isolated from leukemia blasts of 10 patients with t(8;21)‐positive AML and the Kasumi‐1 cells were analyzed by Western blotting. The 94 kDa AML1–ETO fusion protein was detected in all samples. However, this fusion protein was not detectable in all 40 patients with t(8;21)‐negative AMLs. The biological significance of AML1–ETO was examined in K562 cells, which stably overexpress AML1–ETO. We found that AML1–ETO blocked the erythroid differentiation of K562 cells induced by low doses of Ara‐C. Thus, t(8;21)‐positive AMLs appear to overexpress the AML1–ETO fusion protein, which may be responsible for differentiation block and leukemogenesis in AML.
Developing theory and practice: Creation of a Community of Practice through Action Research produced excellence in stroke care

Much emphasis is placed on expert knowledge like evidence-based stroke guidelines, with insufficient attention paid to processes required to translate this into delivery of everyday good care. This paper highlights the worth of creating a Community of Practice (CoP) as a means to achieve this. Drawing on findings from a study conducted in 20002002 of processes involved in establishing a nationally lauded high quality Stroke Unit, it demonstrates how successful development of a new service was linked to creation of a CoP. Recent literature suggests CoPs have a key in implementing evidence-based practice; this study supports this claim whilst revealing for the first time the practical knowledge and skills required to develop this style of working. Findings indicate that participatory and democratic characteristics of Action Research are congruent with the collaborative approach required for developing a CoP. The study is an exemplar of how practitioner researchers can capture learning from changing practice, thus contributing to evidence-based healthcare with theoretical and practical knowledge. Findings are relevant to those developing stroke services globally but also to those interested in evidence-based practice.
Gastrointestinal disorders next to respiratory infections as leading symptoms of X-linked agammaglobulinemia in children – 34-year experience of a single center

Introduction Respiratory tract infections constitute the most frequent manifestation of X-linked agammaglobulinemia (XLA). There are not many papers elucidating gastrointestinal (GI) disorders, including inflammatory bowel disease (IBD), in such patients. The aim of the study was to evaluate the occurrence of gastrointestinal disorders and IBD compared to respiratory tract infections in XLA individuals. Material and methods Of 1563 patients with primary immunodeficiencies diagnosed in the Department of Immunology, the Children’s Memorial Health Institute (CMHI), 66 boys had a provisional diagnosis of agammaglobulinemia. Forty-four subjects fulfilled definitive ESID (European Society for Immunodeficiencies) diagnostic criteria of XLA. A retrospective analysis of medical history of XLA patients was undertaken. Results Recurrent respiratory tract infections, particularly bronchitis (73%) and pneumonia (59%), were the most common symptoms of XLA. The GI disorders constituted the next main manifestation (63.6%), followed by upper respiratory tract infections. Twenty-six of 28 XLA patients with GI disorders complained of diarrhea, which was resolved generally after immunoglobulin therapy introduction. Single but prolonged episodes of Campylobacter jejuni diarrhea were reported in two individuals. Inflammatory bowel disease of mild to moderate activity was diagnosed in 1 patient, and local enteritis of mild activity in another one. Conclusions Gastrointestinal disorders were one of the main manifestations of XLA, reported almost as often as lower respiratory tract infections. The most common GI symptom was diarrhea, which usually resolved after immunoglobulin therapy was started. Infections caused by Giardia lamblia were reported occasionally. Inflammatory bowel disease was diagnosed quite exceptionally, which presumably may be connected with normal T cell immunity.
Managers Develop Moral Accountability: The Impact of Socratic Dialogue

How can organisations ‘manage for integrity’? 1 Two differing approaches have been called the compliance strategy and the integrity strategy. While the first seeks to instil compliance with externally imposed standards, the integrity strategy seeks to teach ethical decision-making and values as well, so that ‘ethical thinking and awareness…[are]…part of every manager’s mental equipment’. In this paper the Dutch consultant philosopher Hans Bolten reports on how Socratic dialogue has helped managers develop ethical capacities and responsibility. Drawing on research with dialogue members he concludes that organisations that care about ethics cannot rely on abstract moral codes and rules. He argues that they need Socratic dialogue as an instrument if their managers are to shape moral guidelines they both agree upon and can apply in practice. And he shows how dialogue can foster in managers the readiness to give an account of their actions, a readiness implicit in the idea of moral action itself. Thus Socratic dialogue can help create a culture in which morally accountable action is the rule, not the exception, and in which the responsibility to give an account of one’s actions has its rightful place.2
Obesity Impact on the Attentional Cost for Controlling Posture

Background This study investigated the effects of obesity on attentional resources allocated to postural control in seating and unipedal standing. Methods Ten non obese adults (BMI = 22.4±1.3, age = 42.4±15.1) and 10 obese adult patients (BMI = 35.2±2.8, age = 46.2±19.6) maintained postural stability on a force platform in two postural tasks (seated and unipedal). The two postural tasks were performed (1) alone and (2) in a dual-task paradigm in combination with an auditory reaction time task (RT). Performing the RT task together with the postural one was supposed to require some attentional resources that allowed estimating the attentional cost of postural control. 4 trials were performed in each condition for a total of 16 trials. Findings (1) Whereas seated non obese and obese patients exhibited similar centre of foot pressure oscillations (CoP), in the unipedal stance only obese patients strongly increased their CoP sway in comparison to controls. (2) Whatever the postural task, the additional RT task did not affect postural stability. (3) Seated, RT did not differ between the two groups. (4) RT strongly increased between the two postural conditions in the obese patients only, suggesting that body schema and the use of internal models was altered with obesity. Interpretation Obese patients needed more attentional resources to control postural stability during unipedal stance than non obese participants. This was not the case in a more simple posture such as seating. To reduce the risk of fall as indicated by the critical values of CoP displacement, obese patients must dedicate a strong large part of their attentional resources to postural control, to the detriment of non-postural events. Obese patients were not able to easily perform multitasking as healthy adults do, reflecting weakened psycho-motor abilities.
Posterior reversible encephalopathy syndrome in infection, sepsis, and shock.

BACKGROUND AND PURPOSE The cause of "posterior reversible encephalopathy syndrome" (PRES) is not established. We recently encountered several patients who developed PRES in the setting of severe infection. In this study, we comprehensively reviewed the clinical and imaging features in a large cohort of patients who developed PRES, with particular attention to those with isolated infection, sepsis, or shock (I/S/S). METHODS The clinical/imaging features of 106 patients who developed PRES were comprehensively evaluated. In 25 of these patients, PRES occurred in association with severe I/S/S separate from transplantation. The clinical/imaging features (computer tomography, MR imaging, and MR angiography [MRA]) of the patients with I/S/S were further evaluated, including organ/tissue/blood culture results, mean arterial blood pressure (MAP) at toxicity, extent of cerebral edema, and presence of vasospasm. RESULTS PRES occurred in association with I/S/S in 25 of 106 patients (23.6%), in addition to 4 other major clinical settings, including cyclosporine/FK-506 (post-transplant) neurotoxicity (46.2%), autoimmune disease (10.4%), postchemotherapy (3.7%), and eclampsia (10.4%). In the 25 patients with I/S/S, available cultures demonstrated a predominance of gram-positive organisms (84%). Blood pressure was "normal" at toxicity in 10 patients (MAP, 95 mm Hg); "severe" hypertension was present in 15 patients (MAP, 137 mm Hg). Extent of brain edema graded on imaging studies was greater in the normal MAP group compared with the severe hypertension group (P < .05). MRA demonstrated vasospasm in patients with severe hypertension and vessel "pruning" in the normal MAP group. CONCLUSION Infection/sepsis/shock may be an important cause of PRES, particularly in relation to infection with gram-positive organisms.
Cardiovascular Involvement in Children with Osteogenesis Imperfecta

Objective Osteogenesis imperfecta is a hereditary disease resulting from mutation in type I procollagen genes. One of the extra skeletal manifestations of this disease is cardiac involvement. The prevalence of cardiac involvement is still unknown in the children with osteogenesis imperfecta. The present study aimed to investigate the prevalence of cardiovascular abnormalities in these patients. Methods 24 children with osteogenesis imperfecta and 24 normal children who were matched with the patients regarding sex and age were studied. In both groups, standard echocardiography was performed, and heart valves were investigated. Dimensions of left ventricle, aorta annulus, sinotubular junction, ascending and descending aorta were measured and compared between the two groups. Findings The results revealed no significant difference between the two groups regarding age, sex, ejection fraction, shortening fraction, mean of aorta annulus, sinotubular junction, ascending and descending aorta, but after correction based on the body surface area, dimensions of aorta annulus, sinotubular junction, ascending and descending aorta in the patients were significantly higher than those in the control group (P<0.05). Two (8.3%) patients had aortic insufficiency and five (20%) patients had tricuspid regurgitation, three of whom had gradient >25 mmHg and one patient had pulmonary insufficiency with indirect evidence of pulmonary hypertension. According to Z scores of aorta annulus, sinotubular junction and ascending aorta, 5, 3, and 1 out of 24 patients had Z scores >2 respectively. Conclusion The prevalence of valvular heart diseases and aortic root dilation was higher in children with osteogenesis imperfecta. In conclusion, cardiovascular investigation is recommended in these children.
Characterization of the Bone Morphogenetic Protein-2 as a Neurotrophic Factor

Rat pheochromocytoma PC12 cells are shown to express a single class of high affinity binding sites for bone morphogenetic protein (BMP)-2 (1,300 receptors/cell, Kd = 31.3 pM). Affinity cross-linking using radiolabeled BMP-2 demonstrated the presence of six components with apparent molecular masses of 170, 155, 105, 90, 80, and 70 kDa. BMP-2 induced morphological changes in PC12 cells with the concomitant expression of three neurofilament proteins. Thus, BMP-2 would appear to be another neurotrophic factor that, like nerve growth factor or basic fibroblast growth factor, stimulates the neuronal differentiation of PC12 cells. Unlike nerve growth factor and basic fibroblast growth factor, however, BMP-2 failed to induce the activation of either 41- and 43-kDa mitogen-activated protein (MAP) kinases or the MAP kinase/extracellular signal-regulated kinase kinase (MEK). Also, BMP-2 did not induce the expression of the c-fos gene in PC12 cells. Activin A was also capable of inducing the neuronal differentiation of PC12 cells without activating MAP kinases and MEK. These findings show a clear dissociation between the requirement for the activation of the MAP kinase cascade and the ability of BMP-2 and activin A to induce PC12 cell neuronal differentiation. In addition, these results suggest that the activation of MAP kinases and MEK is not an absolute requirement for PC12 cell differentiation.
The Relationship between Visual Persistence and Event Perception in Bistable Motion Display

observers viewed two alternating frames, each consisting of three rectangular bars displaced laterally by one cycle in one frame with respect to the other. At long interframe intervals (IFIs) observers perceived a group of three bars moving as a whole (group motion), and at short IFIs the overlapping elements in the two frames appeared stationary, while the third element appeared to move from one end of the display to the other (element motion). The upper temporal limit for perceiving element motion was reduced when bars with blurred edges were used and when either frame duration or bar size was increased. However, when inner and outer elements had different sizes, the element motion percept was dominant up to 230 ms IFI. These findings may be interpreted in terms of spatial tuning of motion mechanisms involved in the perception of bistable apparent motion.
Neural Processes Supporting Young and Older Adults' Emotional Memories

Young and older adults are more likely to remember emotional information than neutral information. The present functional magnetic resonance imaging study examined the neural processes supporting young (ages 1835) and older (ages 6279) adults' successful encoding of positive, negative, and neutral objects (e.g., a sundae, a grenade, a canoe). The results revealed general preservation of the emotional memory network across the age groups. Both groups recruited the amygdala and the orbito-frontal cortex during the successful encoding of positive and negative information. Both ages also showed valence-specific recruitment: right fusiform activity was greatest during the successful encoding of negative information, whereas left prefrontal and temporal activity was greatest during the successful encoding of positive information. These valence-specific processes are consistent with behavioral evidence that negative information is processed with perceptual detail, whereas positive information is processed at a conceptual or schematic level. The only age differences in emotional memory emerged during the successful encoding of positive items: Older adults showed more activity in the medial prefrontal cortex and along the cingulate gyrus than young adults. Because these regions often are associated with self-referential processing, these results suggest that older adults' mnemonic boost for positive information may stem from an increased tendency to process this information in relation to themselves.