Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of vitamin D deficiency among healthy adolescents.

BACKGROUND Although vitamin D deficiency has been documented as a frequent problem in studies of young adults, elderly persons, and children in other countries, there are limited data on the prevalence of this nutritional deficiency among healthy US teenagers. OBJECTIVE To determine the prevalence of vitamin D deficiency in healthy adolescents presenting for primary care. DESIGN A cross-sectional clinic-based sample. SETTING An urban hospital in Boston. PARTICIPANTS Three hundred seven adolescents recruited at an annual physical examination to undergo a blood test and nutritional and activity assessments. MAIN OUTCOME MEASURES Serum levels of 25-hydroxyvitamin D (25OHD) and parathyroid hormone, anthropometric data, nutritional intake, and weekly physical activity and lifestyle variables that were potential risk factors for hypovitaminosis D. RESULTS Seventy-four patients (24.1%) were vitamin D deficient (serum 25OHD level, </=15 ng/mL [</=37.5 nmol/L]), of whom 14 (4.6%) were severely vitamin D deficient (25OHD level, </=8 ng/mL [</=20 nmol/L]). By using a broader definition (25OHD level, </=20 ng/mL [</=50 nmol/L]), 129 patients (42.0%) were vitamin D insufficient. Serum 25OHD levels were inversely correlated with parathyroid hormone levels (r = -0.29), and were 24% lower during winter compared with summer. In a final multivariate model, season, ethnicity, milk and juice consumption, body mass index, and physical activity were significant independent predictors of hypovitaminosis D. CONCLUSIONS Vitamin D deficiency was present in many US adolescents in this urban clinic-based sample. The prevalence was highest in African American teenagers and during winter, although the problem seems to be common across sex, season, and ethnicity.
Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site

African swine fever virus (ASFV) infection causes endosomal reorganization. Here, we show that the virus causes endosomal congregation close to the nucleus as the infection progresses, which is necessary to build a compact viral replication organelle. ASFV enters the cell by the endosomal pathway and reaches multivesicular late endosomes. Upon uncoating and fusion, the virus should exit to the cytosol to start replication. ASFV remodels endosomal traffic and redistributes endosomal membranes to the viral replication site. Virus replication also depends on endosomal membrane phosphoinositides (PtdIns) synthesized by PIKfyve. Endosomes could act as platforms providing membranes and PtdIns, necessary for ASFV replication. Our study has revealed that ASFV reorganizes endosome dynamics, in order to ensure a productive infection.
Mutational randomness as conditional independence and the experimental vindication of mutational Lamarckism

The Modern Synthesis enshrined natural selection as the driver of adaptive evolution mainly by eliminating competing explanations. One of the eliminated competitors was Lamarckism, particularly ‘mutational Lamarckism’, a hypothesis according to which mutations may be directed towards producing phenotypes that improve the performance of the organism in a particular environment. Contrary to this hypothesis, the Modern Synthesis' view claims that mutations are ‘random’, even though the precise meaning of the term was never formally explicated. Current evidence seemingly in favour of the existence of legitimate cases of mutational Lamarckism has revitalized interest to seek a clarification of the meaning of the term ‘random’ in this context. Herein we analyse previous definitions of random mutations and show that they are deficient in three ways: either they are too wide, or too narrow, or dyadic. We argue that the linguistic expression ‘random mutation’ refers to a triadic rather than a dyadic relationship, propose a new, formal and precise definition based on the probabilistic concept of conditional independence, and finally provide examples of its application. One important consequence of our analysis is that the genomic specificity of the mutational process is not a necessary condition for the existence of mutational Lamarckism.
Revisiting the Association of LMX Quality With Perceived Role Stressors

Although earlier research on leader-member exchange (LMX) theory supported a negative linear relationship between LMX quality and role stressors, recent studies suggest that a more complex, nonlinear relationship may exist between LMX quality and variables traditionally associated with it. Based on communication research of LMX and social exchange theory, the aim of this article is to revisit the relationship between LMX quality and role stressors by reconceptualizing their associations and testing the hypotheses of an inverted U relationship. A survey study among immigrant employees revealed differential effects of LMX quality on role stressors. In particular, with role conflict and role overload LMX quality was found to have an inverted U relationship, but a negative linear relationship with role ambiguity. These findings challenge the prevailing assumptions and carry significant theoretical and practical implications.
Spark plasma sintering of zirconium carbide and oxycarbide: Finite element modeling of current density, temperature, and stress distributions

A combined experimental/numerical approach was developed to determine the distribution of current density, temperature, and stress arising within the sample during spark plasma sintering (SPS) treatment of zirconium carbide (ZrC_x) or oxycarbide (ZrC_xO_y). Stress distribution was calculated by using a numerical thermomechanical model, assuming that a slip without mechanical friction exists at the interfaces between the sample and the graphite elements. Heating up to 1950 °C at 100 °C min^−1 and a constant applied pressure of 100 MPa were retained as process conditions. Simulated temperature distributions were found to be in excellent agreement with those measured experimentally. The numerical model confirms that, during the zirconium oxycarbide sintering, the temperature measured by the pyrometer on the die surface largely underestimates the actual temperature of the sample. This real temperature is in fact near the optimized sintering temperature for hot-pressed zirconium oxycarbide specimens. It is also shown that high stress gradients existing within the sample are much higher than the thermal ones. The amplitude of the stress gradients was found to be correlated with those of temperature even if they are also influenced by the macroscopic sample properties (coefficient of thermal expansion and elastic modulus). At high temperature, the radial and angular stresses, which are much higher than the vertical applied stress, provide the more significant contribution to the stress-related driving force for densification during the SPS treatment. The heat lost by radiation toward the wall chambers controlled both the thermal and stress gradients.
Fine-mapping quantitative trait loci with a medium density marker panel: efficiency of population structures and comparison of linkage disequilibrium linkage analysis models

Summary Recently, a Haley–Knott-type regression method using combined linkage disequilibrium and linkage analyses (LDLA) was proposed to map quantitative trait loci (QTLs). Chromosome of 5 and 25 cM with 0·25 and 0·05 cM, respectively, between markers were simulated. The differences between the LDLA approaches with regard to QTL position accuracy were very limited, with a significantly better mean square error (MSE) with the LDLA regression (LDLA_reg) in sparse map cases; the contrary was observed, but not significantly, in dense map situations. The computing time required for the LDLA variance components (LDLA_vc) model was much higher than the LDLA_reg model. The precision of QTL position estimation was compared for four numbers of half-sib families, four different family sizes and two experimental designs (half-sibs, and full- and half-sibs). Regarding the number of families, MSE values were lowest for 15 or 50 half-sib families, differences not being significant. We observed that the greater the number of progenies per sire, the more accurate the QTL position. However, for a fixed population size, reducing the number of families (e.g. using a small number of large full-sib families) could lead to less accuracy of estimated QTL position.
SMASH: One-Shot Model Architecture Search through HyperNetworks

Designing architectures for deep neural networks requires expert knowledge and substantial computation time. We propose a technique to accelerate architecture selection by learning an auxiliary HyperNet that generates the weights of a main model conditioned on that model's architecture. By comparing the relative validation performance of networks with HyperNet-generated weights, we can effectively search over a wide range of architectures at the cost of a single training run. To facilitate this search, we develop a flexible mechanism based on memory read-writes that allows us to define a wide range of network connectivity patterns, with ResNet, DenseNet, and FractalNet blocks as special cases. We validate our method (SMASH) on CIFAR-10 and CIFAR-100, STL-10, ModelNet10, and Imagenet32x32, achieving competitive performance with similarly-sized hand-designed networks. Our code is available at this https URL
Farrington, T and Coward, T and Onambele-Pearson, G and Taylor, RL and Earl, P and Winwood, K (2015)The effect of model inclination during fabri- cation on mouthguard calliper-measured and CT scan-assessed thickness

Aim: Excessive material thinning has been observed in the production of custom-made mouthguards in a number of studies, due to production anomalies that may lead to such thinning. This study investigated the effect of thinning material patterns of custom made mouthguards when the anterior angulation of dental model was increased during the thermoforming process. Materials & Methods: A total of 60 samples of mouthguard blanks were thermoformed on identical maxillary models under four anterior inclination conditions (n=4×15); control 0°, 15°, 30°, and 45° . Each mouthguard sample was measured, using an electronic calliper gauge, at 3 anatomical points (anterior labial sulcus, posterior occlusion and posterior lingual). Mouthguards were then CT scanned to give a visual representation of the surface thickness. Results: Data showed a significant difference (p < 0.005) in the anterior mouthguard thickness between the four levels of anterior inclination, with the 45° inclination producing the thickest mouthguards, increasing the mean anterior thickness by 75% (2.8mm, SD: 0.16) from the model on a flat plane (1.6mm, SD: 0.34). Anterior model inclination of 30o and 45o inclinations increased consistancies between the thickest and thinnest mouthguards in the anterior region of these sample groups. Conclusion: This study highlights the importance of standardising the thermoforming process, as this has a significant effect on the quality and material distribution of the resultant product. In particular, greater model inclination is advised as this optimises the thickness of the anterior sulcus of the mouthguard which may be more prominently at risk from sportrelated impact.
Exposure to Concentrated Ambient PM2.5 Compromises Spermatogenesis in a Mouse Model: Role of Suppression of Hypothalamus-Pituitary-Gonads Axis

Epidemiological studies link ambient fine particulate matter (PM2.5) pollution to abnormalities in the male reproductive system. However, few toxicological studies have investigated this potentially important adverse effect of PM2.5 pollution. Therefore, in the present study, we analyzed the effects of PM2.5 exposure on spermatogenesis and hypothalamic-pituitary-gonadal (HPG) axis in a murine model. Fourteen male C57BL/6J mice were subjected to a 4-month exposure to filtered air or concentrated ambient PM2.5 (CAP). Their sperm count, testicular histology, spermatogenic parameters, and the major components of HPG axis were assessed. Exposure to CAP significantly reduced sperm count in the epididymis. This was accompanied by Sertoli cell vacuolization, immature germ cell dislocation, and decreases in pachytene spermatocytes and round spermatids of stage VII seminiferous tubules, suggesting a marked impairment of spermatogenesis in these mice. This impairment of spermatogenesis appeared to be attributable to a suppression of HPG axis subsequent to CAP exposure-induced hypothalamic inflammation, as exposure to CAP significantly increased TNFα and IL1b mRNA levels and meanwhile decreased gonadotropin-releasing hormone mRNA expression in the hypothalamus. Moreover, CAP exposure significantly reduced circulating testosterone and follicle-stimulating hormone, testicular testosterone and mRNA expression of follicle-stimulating hormone target gene SHBG and luteinizing hormone target genes P450scc, 17βHSD, and StAR. The present data demonstrate that exposure to ambient PM2.5 impairs spermatogenesis in murine model, raising the concern over effects of ambient PM2.5 pollution on the male reproductive function.
Epidemiology and prognosis of brain metastases

A substantial, but uncertain, number of patients with cancer develop brain metastases. Risk of brain metastasis is recognized to vary with type of primary cancer. Within specific types of primary cancer, prognostic factors for development of brain metastases are being recognized. Recent data suggest that molecular biomarkers that relate to cellular function can predict risk of developing brain metastases. Such information could optimize surveillance standards and/or be used to select patients for preventive interventions. Though average survival for patients with brain metastases is typically less than 6 months, it is well-recognized that subgroups of patients have significant probability of longer survival. Multiple prognostic models have been proposed, validated, and compared without clearly demonstrating superiority of one model over another. However, some factors show consistency as predictive variables across models, and performance status is almost universally significant. Application of predictive models to specific treatments has been difficult. Tumor-specific prognostic models are evolving, and combinations of biological and clinical factors may be used to optimize models for particular primary tumor types.
Changing Dynamics of HIV Transmission in Côte d'Ivoire: Modeling Who Acquired and Transmitted Infections and Estimating the Impact of Past HIV Interventions (1976–2015)

Introduction: Understanding the impact of past interventions and how it affected transmission dynamics is key to guiding prevention efforts. We estimated the population-level impact of condom, antiretroviral therapy (ART), and prevention of mother-to-child transmission activities on HIV transmission and the contribution of key risk factors on HIV acquisition and transmission. Methods: An age-stratified dynamical model of sexual and vertical HIV transmission among the general population, female sex workers (FSW), and men who have sex with men was calibrated to detailed prevalence and intervention data. We estimated the fraction of HIV infections averted by the interventions, and the fraction of incident infections acquired and transmitted by different populations over successive 10-year periods (1976–2015). Results: Overall, condom use averted 61% (95% credible intervals: 56%–66%) of all adult infections during 1987–2015 mainly because of increased use by FSW (46% of infections averted). In comparison, ART prevented 15% (10%–19%) of adult infections during 2010–2015. As a result, FSW initially (1976–1985) contributed 95% (91%–97%) of all new infections, declining to 19% (11%–27%) during 2005–2015. Older men and clients mixing with non-FSW are currently the highest contributors to transmission. Men who have sex with men contributed ⩽4% transmissions throughout. Young women (15–24 years; excluding FSW) do not transmit more infections than they acquired. Conclusions: Early increases in condom use, mainly by FSW, have substantially reduced HIV transmission. Clients of FSWs and older men have become the main source of transmission, whereas young women remain at increased risk. Strengthening prevention and scaling-up of ART, particularly to FSW and clients of female sex workers, is important.
A Closed Form Solution for the Energy Release Rate of the Double Cantilever Beam Specimen with an Adhesive Layer

A simple, yet accurate, strength of materials approach is used to derive a closed form solution for the compliance and energy release rate of the double cantilever beam specimen with an adhesive layer and cohesive cracks. Such capability currently is not available in the literature. The results are valid for either isotropic or orthotropic mate nals in plane stress or plane strain. The specimen is modelled as a beam partially free and partially supported by an elastic foundation. The solution is an extension of previous work by Kanninen [1] for the special case of a homogeneous material (e.g., no adhesive layer). The closed form results are subsequently verified using the finite element method. Ex cellent agreement is found for a variety of crack lengths and material properties. It is shown that, for composite adherends, shear deformation must be taken into account in ad dition to elastic foundation effects. The present results are useful in analyzing test results to determine the fracture toughness of adhesives and composite laminates with adhesive interlayers or resin rich ply interfaces, and in sizing specimens.
History of Childhood Kidney Disease and Risk of Adult End‐Stage Renal Disease

Background The long‐term risk associated with childhood kidney disease that had not progressed to chronic kidney disease in childhood is unclear. We aimed to estimate the risk of future end‐stage renal disease (ESRD) among adolescents who had normal renal function and a history of childhood kidney disease. Methods We conducted a nationwide, population‐based, historical cohort study of 1,521,501 Israeli adolescents who were examined before compulsory military service in 1967 through 1997; data were linked to the Israeli ESRD registry. Kidney diseases in childhood included congenital anomalies of the kidney and urinary tract, pyelonephritis, and glomerular disease; all participants included in the primary analysis had normal renal function and no hypertension in adolescence. Cox proportional‐hazards models were used to estimate the hazard ratio for ESRD associated with a history of childhood kidney disease. Results During 30 years of follow‐up, ESRD developed in 2490 persons. A history of any childhood kidney disease was associated with a hazard ratio for ESRD of 4.19 (95% confidence interval [CI], 3.52 to 4.99). The associations between each diagnosis of kidney disease in childhood (congenital anomalies of the kidney and urinary tract, pyelonephritis, and glomerular disease) and the risk of ESRD in adulthood were similar in magnitude (multivariable‐adjusted hazard ratios of 5.19 [95% CI, 3.41 to 7.90], 4.03 [95% CI, 3.16 to 5.14], and 3.85 [95% CI, 2.77 to 5.36], respectively). A history of kidney disease in childhood was associated with younger age at the onset of ESRD (hazard ratio for ESRD among adults <40 years of age, 10.40 [95% CI, 7.96 to 13.59]). Conclusions A history of clinically evident kidney disease in childhood, even if renal function was apparently normal in adolescence, was associated with a significantly increased risk of ESRD, which suggests that kidney injury or structural abnormality in childhood has long‐term consequences.
Bayesian Estimation of Pneumonia Etiology: Epidemiologic Considerations and Applications to the Pneumonia Etiology Research for Child Health Study

Abstract In pneumonia, specimens are rarely obtained directly from the infection site, the lung, so the pathogen causing infection is determined indirectly from multiple tests on peripheral clinical specimens, which may have imperfect and uncertain sensitivity and specificity, so inference about the cause is complex. Analytic approaches have included expert review of case-only results, case–control logistic regression, latent class analysis, and attributable fraction, but each has serious limitations and none naturally integrate multiple test results. The Pneumonia Etiology Research for Child Health (PERCH) study required an analytic solution appropriate for a case–control design that could incorporate evidence from multiple specimens from cases and controls and that accounted for measurement error. We describe a Bayesian integrated approach we developed that combined and extended elements of attributable fraction and latent class analyses to meet some of these challenges and illustrate the advantage it confers regarding the challenges identified for other methods.
Adapting the vertical position of implants with a conical connection in relation to soft tissue thickness prevents early implant surface exposure: A 2‐year prospective intra‐subject comparison

AIM To evaluate the effect of soft tissue thickness on bone remodelling and to investigate whether implant surface exposure can be avoided by adapting the vertical implant position in relation to the soft tissue thickness. MATERIALS AND METHODS Twenty-five patients received two non-splinted implants supporting an overdenture in the mandible. Soft tissue thickness was measured using bone sounding and ultrasonically. One implant was installed equicrestally (control), and the vertical position of the second implant was adapted to the site-specific soft tissue thickness (test). Crestal bone levels were determined on digital peri-apical radiographs and compared with baseline (implant placement). RESULTS Twenty-five patients were consecutively treated. No implants failed during the follow-up. A significant correlation was observed between soft tissue thickness and bone level alterations after 6 months (ultrasound ICC = 0.610; bone sounding ICC = 0.641) with inferior bone levels for equicrestal implants when thin tissues are present. Subcrestal implants showed significantly better bone levels after 6-month (n = 24, 0.04 mm versus 0.72 mm; p < .001), 1-year (n = 24, 0.03 mm versus 0.77 mm; p < .001) and 2-year follow-up (n = 24, 0.04 mm versus 0.73 mm; p < .001). CONCLUSION Initial bone remodelling was affected by soft tissue thickness. Anticipating biologic width re-establishment by adapting the vertical position of the implant seemed highly successful to avoid implant surface exposure.
Justice Without Borders

The present research examines how psychological distance influences the weight given to individuating information about targets of justice judgments. Drawing on construal level theory, which links psychological distance to levels of construal, we hypothesize that increasing psychological distance from justice judgments reduces people’s sensitivity to specific features of targets, thereby minimizing the extent to which applications of justice are influenced by target-specific information. Psychological proximity, by contrast, enhances the salience of targets’ idiosyncratic characteristics, thereby leading to applications of justice that are more sensitive to targets’ identity. Six studies, examining various justice principles, support these conclusions. Studies 1 to 3 show that psychological distancing reduces the weight of target-specific features in justice judgments. Supporting the role of construal level in driving these results, Studies 4 to 6 demonstrate parallel patterns when construal level is manipulated directly. This work offers a novel outlook on the role of construal and target characteristics in moral exclusion.