Miracle-dz/UniFAR-FTUs huggingface dataset:
Spectral frequency analysis of dynamic balance in healthy and injured athletes.

Different neurophysiological circuits underlie the various frequencies of the body sway for the regulation of human upright posture. Servo-controlled platforms allowed experimental studies about latency responses after a sudden external disturbance but power frequency repartition during spontaneous dynamic equilibrium has rarely been examined. The purpose of the present study was to examine the zone of sway frequency assigned to proprioceptive afferences from muscular, articular and tendinous receptors in healthy and injured subjects standing on an unstable and minimal area. Dynamic balance conditions were realized by asking athletes to stand up on a seesaw (stabilometer). The recordings (stabilograms) were monitored by means of an accelerometer. Their power spectra were obtained by a fast Fourier transform process. A first study was conducted in order to specify the contribution of articular receptors of the ankle in the regulation of spontaneous dynamic equilibrium of five soccer players with unilateral injured ankle (IA). The balance parameters in lateral sways were measured in monopodal stance on the healthy ankle (HA) comparatively to IA. The stabilogram was longer (P < 0.05), the total energy of 2-20 Hz band (P < 0.01) higher in the IA (1074 +/- 111 mm and 53 +/- 8 V2) than in the HA (836 +/- 150 mm and 36 +/- 8 V2). A second study analyzed the contribution of knee articular receptors involved in the reflexes of antigravity extension. We assessed during bipodal stance the anteroposterior sways of five basketball players with injured knee (IK) and 3 with healthy knee (HK) in eyes-open and eyes-closed situations. (ABSTRACT TRUNCATED AT 250 WORDS)
The Role of Self-Regulation Training in Developing the Motivation Management Capabilities of Salespeople

Time management, goal setting, goal attainment strategies, prioritization techniques! These are some of the self-regulation skills that today’s sales organizations are attempting to develop in a sales force through self-regulation training. This study empirically investigates self-regulation training and how it can facilitate salesperson performance. Findings suggest that self-regulatory training can enhance salesperson self-regulation capabilities, decrease role ambiguity, and thereby aid sales performance. Furthermore, our findings suggest that the value of self-regulation training may not be uniform across all sales trainees. Specifically, self-regulation training may be more beneficial to salespeople after they have developed a level of mastery over fundamental core selling capabilities.
Variable optical polarization during high state in γ-ray loud, narrow-line Seyfert 1 galaxy 1H 0323+342

We present results of optical polarimetric and multi-band photometric observations for gamma-ray loud narrow-line Seyfert 1 galaxy 1H 0323+342. This object has been monitored by 1.5 m Kanata telescope since 2012 September but following a gamma-ray flux enhancement detected by Fermi-LAT on MJD 56483 (2013 July 10) dense follow-up was performed by ten 0.5-2.0 m telescopes in Japan over one week. The 2-year R_C-band light curve showed clear brightening corresponding to the gamma-ray flux increase and then decayed gradually. The high state as a whole lasted for ~20 days, during which we clearly detected optical polarization from this object. The polarization degree (PD) of the source increased from 0-1% in quiescence to ~3% at maximum and then declined to the quiescent level, with the duration of the enhancement of less than 10 days. The moderate PD around the peak allowed us to precisely measure the daily polarization angle (PA). As a result, we found that the daily PAs were almost constant and aligned to the jet axis, suggesting that the magnetic field direction at the emission region is transverse to the jet. This implies either a presence of helical/toroidal magnetic field or transverse magnetic field compressed by shock(s). We also found small-amplitude intra-night variability during the 2-hour continuous exposure on a single night. We discuss these findings based on the turbulent multi-zone model recently advocated by Marscher (2014). Optical to ultraviolet (UV) spectrum showed a rising shape in the higher frequency and the UV magnitude measured by Swift/UVOT was steady even during the flaring state, suggesting that thermal emission from accretion disk is dominant in that band.
Prognostic factors in patients with nasopharyngeal carcinoma treated in Hospital Kuala Lumpur.

BACKGROUND Nasopharyngeal carcinoma is the third most common cancer among men in Peninsular Malaysia. However, no information is available about the prognostic factors. The objective of this study was to identify factors with an influence on outcome in patients treated in Hospital Kuala Lumpur. METHODS A total of 159 patients with non-metastatic nasopharyngeal carcinoma treated during 2002-2003 in Hospital Kuala Lumpur were included in this study. All received radiotherapy. Fifty three patients were treated with radiotherapy alone, while 106 patients received combination chemotherapy. Overall survival and local recurrence-free survival were analyzed using the Kaplan-Meier method and univariate analysis was performed using the log-rank test. RESULTS This study found out that 5-year overall survival and 5-year local recurrence-free survival rates were 58.6% and 54.2% respectively. The stage specific 5-year overall survival rates were: Stage I, 100%; Stage II; 93.3%, Stage III, 62.7%; Stage IVA, 42.2%; and Stage IVB, 40.6%. On univariate analysis, gender (p<0.05), T-classification (p<0.001), N-classification (p<0.05), stage (p<0.05) and cranial nerve involvement (p<0.001) were found to be significant prognostic factors for 5-year overall survival, while gender (p<0.05) and N-classification (p<0.05) were significant prognostic factors for 5-year local recurrence-free survival. CONCLUSION The overall survival rate of patients for this study was low. The patient factor that significantly affected 5-year overall survival was gender, while disease factors were stage, T-classification, N-classification and cranial nerve involvement.
Sparking Creativity: Improving Electronic Brainstorming with Individual Cognitive Priming

In recent years, there has been growing interest in the study of individual cognition in teams. Meanwhile, we learned that much of human behavior involves nonconscious cognition. Recent research has shown that it is possible to manipulate nonconscious cognition through "priming. " Priming is a well-known phenomenon for individual behavior, but we do not know whether priming can be used to influence team behavior. We developed a Web-based computer game that was designed to improve creativity through supraliminal priming, a form of priming in which users are aware of the priming, but not aware of its purpose. Participants were exposed to a priming game and then worked as members of a team to generate ideas on a creativity task. Our results show that when users played the game designed to improve performance, their teams generated significantly more ideas that were of better quality than when they were exposed to neutral priming.
Math Performance in Stressful

Whether because individuals are made aware of negative stereotypes about how they should perform or are in a high-stakes testing situation, a stressful environ- mentcanadverselyaffectthesuccesspeoplehaveinsolving math problems. I review work examining how unwanted failure in math occurs and individual differences in those most likely to fail. This work suggests that a high-stress situation creates worries about the situation and its consequences that compete for the working memory (WM) normally available for performance. Consequently, the performance of individuals who rely most heavily on WM for successful execution (i.e., higher-WM individuals) is most likely to decline when the pressure is on.
Spectrum and immediate outcome of seizures in neonates.

OBJECTIVE To determine the frequency, etiology, the clinical types, and outcome of seizures in neonates during the course of stay in the neonatal unit. STUDY DESIGN Cross-sectional study. PLACE AND DURATION Pediatric Department, LMCH, from February 2000 to April 2001. PATIENTS AND METHODS All neonates (1-28 days) presented with seizures during that period were included in the study. Their detailed history, physical examination, and appropriate investigations were recorded on a study proforma. RESULTS Out of a total 680 patients, 100 patients presented with the seizures; this comprises the frequency of 14.7%. Male to female ratio was 2.1:1. Regarding gestational age, 65% were full-term, 31% were pre-term, and 4% were post-term. Regarding etiology, 40% patients had birth asphyxia; 14% had hypoglycemia; 12% were due to hypocalcaemia, 5% were due to intracranial hemorrhage (ICH), 4% had malformation, 10 % had infection /neonatal sepsis, and in 12%, the etiology was kernicterus. Among the patients with seizures, 45% were completely recovered and discharged and 15% patients had neurological deficit at the time of discharge. From the hospitalized 100 patients, 22% expired. The critical factors for the outcome were etiology, gestational age, birth weight, APGAR score, and clinical characteristics. Generally, birth asphyxia had poor, while metabolic causes had good prognosis. CONCLUSION Frequency of seizures was higher in full term (65%) neonates than pre-term (31%). Among the etiological factors birth asphyxia was found to be the most common cause, and showed unfavorable outcome in this series. Common risk factors were low birth weight, pre-maturity, home delivery, pregnancy-induced hypertension and premature rupture of membranes.
Association between habenula dysfunction and motivational symptoms in unmedicated major depressive disorder

Abstract The lateral habenula plays a central role in reward and punishment processing and has been suggested to drive the cardinal symptom of anhedonia in depression. This hypothesis is largely based on observations of habenula hypermetabolism in animal models of depression, but the activity of habenula and its relationship with clinical symptoms in patients with depression remains unclear. High-resolution functional magnetic resonance imaging (fMRI) and computational modelling were used to investigate the activity of the habenula during a probabilistic reinforcement learning task with rewarding and punishing outcomes in 21 unmedicated patients with major depression and 17 healthy participants. High-resolution anatomical scans were also acquired to assess group differences in habenula volume. Healthy individuals displayed the expected activation in the left habenula during receipt of punishment and this pattern was confirmed in the computational analysis of prediction error processing. In depressed patients, there was a trend towards attenuated left habenula activation to punishment, while greater left habenula activation was associated with more severe depressive symptoms and anhedonia. We also identified greater habenula volume in patients with depression, which was associated with anhedonic symptoms. Habenula dysfunction may contribute to abnormal response to punishment in patients with depression, and symptoms such as anhedonia.
Progressive lightning. VII Directly-correlated photographic and electrical studies of lightning from near thunderstorms

An analysis has been made of the direct correlation of luminous and electrical field-changes produced by thirty-seven lightning discharges to ground. These discharges comprised 199 separate strokes, most of which were within a distance of 6 km. A new form of drum camera and a camera shutter operated by the first leader were em ployed, and many records were obtained in daylight. When compared with results previously reported for flashes at distances of 10 km. or more, the following major differences are found: negative field-changes from near leaders, absence of electrical effects of first leader steps and hook-shaped field-changes during the period immediately following the return stroke. The hook field-changes are shown to be associated with components in the continuing luminosity of the channel of the type investigated by Malan & Collens and to be due to subsidiary discharges in this channel. These 'M’ components carry negative charge to ground in quantities between one-fifth and one-hundredth of those carried by main strokes. The height of the lower negative charge in these thunderclouds is found to be from 4 to 9 km. During a discharge to ground, no rapid discharges occur within the cloud or elsewhere than in the cloud-ground channel. A fairly slow discharge of the upper positive charge in the thundercloud appears to occur to the upper air immediately after the lower negative pole has discharged to ground.
Plaque hemorrhage is a marker of thromboembolic activity in patients with symptomatic carotid disease.

PURPOSE To assess whether carotid plaque hemorrhage depicted with magnetic resonance (MR) imaging was associated with thromboembolic activity as assessed with transcranial Doppler imaging. MATERIALS AND METHODS The local research ethics committee approved the study, and all patients gave informed written consent. Between April 2005 and December 2006, patients with high-grade symptomatic carotid stenosis were prospectively recruited. All underwent MR imaging of the carotid arteries for plaque hemorrhage and diffusion-weighted imaging of the brain. Transcranial Doppler imaging of the symptomatic carotid artery was performed over 1 hour to assess the presence of microembolic signal. To determine the relationship between the presence of plaque hemorrhage and diffusion-weighted imaging-positive signal and presence of microembolic signal, a logistic regression analysis was performed. RESULTS Fifty-one patients (23 women and 28 men; mean age ± standard deviation, 72 years ± 11) underwent complete MR imaging; 46 (86%) of these patients underwent complete transcranial Doppler imaging. In 32 (63%) patients, there was plaque hemorrhage in the index carotid artery. The presence of plaque hemorrhage increased the risk for ipsilateral abnormalities at diffusion-weighted imaging (odds ratio, 6.2 [95% confidence interval: 1.7, 21.8]; P < .05). Multiple diffusion-weighted imaging-depicted abnormalities of multiple ages were present exclusively in patients with plaque hemorrhage shown at MR imaging (12 of 32 [38%] patients with plaque hemorrhage versus none of 19 patients without plaque hemorrhage; P < .05). The presence of plaque hemorrhage also increased the presence of microembolic signal (odds ratio, 6.0 [95% confidence interval: 1.8, 19.9]; P = .003). CONCLUSION In patients with carotid plaque hemorrhage demonstrated at MR imaging, there was increased spontaneous microembolic activity at transcranial Doppler imaging and cerebral ischemic lesion patterns suggestive of recurrent embolic events; these findings suggest that plaque hemorrhage shown at MR imaging might be a marker of thromboembolic activity and further validate the usefulness of carotid imaging in identifying patients with active carotid arterial disease.
HIV Testing and Sexual Risk Reduction Counseling in Office-Based Buprenorphine/Naloxone Treatment

Objectives:We assessed the feasibility and preliminary efficacy of human immunodeficiency virus (HIV) testing with sexual risk reduction counseling for opioid-dependent patients initiating office-based buprenorphine/naloxone treatment. Methods:We conducted a 14-week randomized, controlled trial with 30 patients (original target of 114) assigned to receive buprenorphine/naloxone induction/stabilization and HIV testing with Brief Sexual Risk Management (BSRM) or Enhanced Sexual Risk Management (ESRM). We evaluated process measures and compared outcomes at baseline and during the 3-month follow-up. Results:Similar proportions of patients receiving BSRM and ESRM underwent HIV testing (93% vs 80%; P = 0.28) and completed counseling sessions (80% vs 67%; P = 0.40). Brief Sexual Risk Management sessions were shorter than ESRM sessions (15.4 vs 23.4 minutes), with comparable manual adherence (P = 0.80). Outcomes did not vary by BSRM versus ESRM. Conclusions:Although the recruitment of opioid-dependent patients with sexual risk behaviors is challenging, HIV testing with sexual risk reduction counseling in office-based buprenorphine/naloxone treatment practice is feasible. Interventions to decrease sexual risk behaviors among a segment of this population are necessary.
Dopamine enhances a glutamate-gated ionic current in OFF bipolar cells of the tiger salamander retina

The transmitter glutamate is thought to be used by all vertebrate photoreceptors to drive the second-order neurons of the retina, horizontal and bipolar neurons. Dopamine, an endogenous retinal neurotransmitter localized to amacrine and interplexiform cells, has previously been shown to enhance glutamate-gated currents in retinal horizontal cells. In the present study we demonstrate that bipolar cells, like horizontal cells, possess glutamate receptors that are modulated by dopamine. We then identify some components of the pathway through which dopamine acts. We used whole-cell patch recording to measure how bath-applied dopamine modulated the currents elicited by puffs of transmitter solutions at bipolar cell dendrites. Excitatory amino acid-gated currents were evoked by pressure ejecting 1 mM glutamate or 10 microM kainate for 40 msec through a micropipette positioned at the dendrites of bipolar cells. Bath-applied dopamine (20 microM) enhanced the response to glutamate in OFF bipolar cells in the retinal slice by 40% and in isolated OFF bipolar cells by 65%. We also explored the components of the intracellular pathway mediating this modulation. Response enhancement was blocked by the D1 receptor antagonist SCH23390, but not by the D2 receptor antagonist spiperone, suggesting that the enhancement by dopamine is mediated by a D1 receptor. GDP-beta-S, a G-protein inactivator, blocked the enhancing action of dopamine, suggesting that the D1 receptor activated a G- protein to enhance the glutamate-gated current. Both 8-(4- chlorophenylthio)adenosine, a cAMP analog, and the addition of the catalytic subunit of protein kinase A (PKA) to the recording pipette enhanced glutamate-gated currents, while H-7, a PK inactivator, and PKI20amide, a PKA-specific inhibitor, blocked the enhancing action of dopamine. These data suggest that dopamine acts at D1 receptors in the dendrites of bipolar cells to activate adenyl cyclase, which through cAMP enhances a glutamate-gated current in bipolar cell dendrites. Thus, dopamine may modulate synaptic transmission from photoreceptors to OFF bipolar cells.
Highly Purified Human Immunodeficiency Virus Type 1 Reveals a Virtual Absence of Vif in Virions

ABSTRACT The vif gene of human immunodeficiency virus type 1 (HIV-1) is essential for the productive infection of primary blood-derived lymphocytes, macrophages, and certain human T-cell lines. It has been shown that Vif is associated with HIV-1 virions purified by sucrose density-equilibrium gradient analysis. However, the specificity of Vif incorporation into virions has not been determined. Moreover, recent studies have demonstrated that standard HIV-1 particle preparations created with sucrose density-equilibrium gradients are contaminated with cell-derived microvesicles. Here we demonstrate, as previously reported, that Vif cosediments with HIV-1 particles in sucrose density-equilibrium gradient analysis. However, we also found that, when Vif was expressed in the absence of all other HIV-1-encoded gene products and then isolated by sucrose density-equilibrium gradient centrifugation from extracellular supernatants, its sedimentation pattern was largely unaltered, suggesting that Vif can be secreted from cells. Using a newly developed OptiPrep velocity gradient method, we were able to physically separate most of the extracellular Vif from the HIV-1 virions without disrupting the infectivity of the virus. By titrating serial dilutions of purified Vif and Gag against the viral peak fraction in the OptiPrep gradient, we demonstrate that <1.0 Vif molecule per virion was present. This study shows that Vif is not significantly present in HIV-1 virions, a finding which is consistent with the idea that Vif functions predominantly in the virus-producing cells during virus assembly. The OptiPrep velocity gradient technique described here could be an easy and rapid way to purify HIV and other enveloped viruses from microvesicles and/or cell debris.
Possible advantages and drawbacks of adding flexible sigmoidoscopy to hemoccult-II in screening for colorectal cancer. A randomized study.

BACKGROUND Flexible sigmoidoscopy (FS) has been recommended as a screening method to reduce mortality from colorectal cancer (CRC). The present study evaluates the effect of adding FS to the fecal occult blood test Hemoccult-II (H-II) on diagnostic yield of colorectal neoplasia. METHODS A total of 10,978 normal persons aged 50-75 years were invited to participate, 5495 persons being allocated at random to H-II and FS and 5483 to H-II alone. RESULTS In spite of a lower compliance (40% versus 56%) for the combined procedure, the diagnostic yield of colorectal neoplasia was higher than for H-II alone (12 CRC versus 4 CRC, and 72 large adenomas versus 14). Within 24-62 months after screening there were fewer CRCs detected after H-II + FS than after H-II alone. The stage distribution was less favorable than in screen-detected cases. CONCLUSION One FS may not be an optimal way of screening, but FS deserves to be evaluated in randomized population studies including repeated H-II tests in the control arm.
Low β2 Main Peak Frequency in the Electroencephalogram Signs Vulnerability to Depression

Objective: After an intense and repeated stress some rats become vulnerable to depression. This state is characterized by persistent low serum BDNF concentration. Our objective was to determine whether electrophysiological markers can sign vulnerability to depression. Methods: Forty-three Sprague Dawley rats were recorded with supradural electrodes above hippocampus and connected to wireless EEG transmitters. Twenty-nine animals experienced four daily social defeats (SD) followed by 1 month recovery. After SD, 14 rats had persistent low serum BDNF level and were considered as vulnerable (V) while the 15 others were considered as non-vulnerable (NV). EEG signals were analyzed during active waking before SD (Baseline), just after SD (Post-Stress) and 1 month after SD (Recovery). Results: We found that V animals are characterized by higher high θ and α spectral relative powers and lower β2 main peak frequency before SD. These differences are maintained at Post-Stress and Recovery for α spectral relative powers and β2 main peak frequency. Using ROC analysis, we show that low β2 main peak frequency assessed during Baseline is a good predictor of the future state of vulnerability to depression. Conclusion: Given the straightforwardness of EEG recordings, these results open the way to prospective studies in humans aiming to identify population at-risk for depression.