Miracle-dz/UniFAR-FTUs huggingface dataset:
Respiratory Syncytial Virus Infections in Infants Affected by Primary Immunodeficiency

Primary immunodeficiencies are rare inherited disorders that may lead to frequent and often severe acute respiratory infections. Respiratory syncytial virus (RSV) is one of the most frequent pathogens during early infancy and the infection is more severe in immunocompromised infants than in healthy infants, as a result of impaired T- and B-cell immune response unable to efficaciously neutralize viral replication, with subsequent increased viral shedding and potentially lethal lower respiratory tract infection. Several authors have reported a severe clinical course after RSV infections in infants and children with primary and acquired immunodeficiencies. Environmental prophylaxis is essential in order to reduce the infection during the epidemic season in hospitalized immunocompromised infants. Prophylaxis with palivizumab, a humanized monoclonal antibody against the RSV F protein, is currently recommended in high-risk infants born prematurely, with chronic lung disease or congenital heart disease. Currently however the prophylaxis is not routinely recommended in infants with primary immunodeficiency, although some authors propose the extension of prophylaxis to this high risk population.
Interpersonal Behavior, Peer Popularity, and Self‐esteem in Early Adolescence

The present study compared the behavioral correlates of sociometric popularity status and consensual popularity status among a large group of children (N = 778) in their first year of secondary school. By means of self-report and classmates’ nomination procedures, the relative contribution of the two types of popularity to peer role strain and self-esteem were investigated. Results indicated large differences in the behavioral correlates of both types of popularity: Sociometric popularity is largely related to cooperative behavior and being perceived as popular. Consensual popularity is highly related to fashion style and being perceived as not boring. The two types of popu-larity were uniquely related to self-esteem levels. Consensual popularity was directly linked to social self-esteem; sociometric popularity appeared to be linked to self-esteem through the reduction of peer role strain levels. The results are discussed in the light of social psychological theories of dominance and prestige among children.
Policy/mechanism separation in Hydra

The extent to which resource allocation policies are entrusted to user-level software determines in large part the degree of flexibility present in an operating system. In Hydra the determination to separate mechanism and policy is established as a basic design principle and is implemented by the construction of a kernel composed (almost) entirely of mechanisms. This paper presents three such mechanisms (scheduling, paging, protection) and examines how external policies which manipulate them may be constructed. It is shown that the policy decisions which remain embedded in the kernel exist for the sole purpose of arbitrating conflicting requests for physical resources, and then only to the extent of guaranteeing fairness.
Analysis of the Estimators of the Average Coefficient of Dominance of Deleterious Mutations

We investigate the sources of bias that affect the most commonly used methods of estimation of the average degree of dominance (h) of deleterious mutations, focusing on estimates from segregating populations. The main emphasis is on the effect of the finite size of the populations, but other sources of bias are also considered. Using diffusion approximations to the distribution of gene frequencies in finite populations as well as stochastic simulations, we assess the behavior of the estimators obtained from populations at mutation-selection-drift balance under different mutational scenarios and compare averages of h for newly arisen and segregating mutations. Because of genetic drift, the inferences concerning newly arisen mutations based on the mutation-selection balance theory can have substantial upward bias depending upon the distribution of h. In addition, estimates usually refer to h weighted by the homozygous deleterious effect in different ways, so that inferences are complicated when these two variables are negatively correlated. Due to both sources of bias, the widely used regression of heterozygous on homozygous means underestimates the arithmetic mean of h for segregating mutations, in contrast to their repeatedly assumed equality in the literature. We conclude that none of the estimators from segregating populations provides, under general conditions, a useful tool to ascertain the properties of the degree of dominance, either for segregating or for newly arisen deleterious mutations. Direct estimates of the average h from mutation-accumulation experiments are shown to suffer some bias caused by purging selection but, because they do not require assumptions on the causes maintaining segregating variation, they appear to give a more reliable average dominance for newly arisen mutations.
Inconclusive triple diagnosis in breast cancer imaging: is there a place for scintimammography?

UNLABELLED Scintimammography (SM) can be used as a complementary test to mammography in patients with suspected breast cancers. This study was undertaken to evaluate the impact of SM on the management of patients with a doubtful or discordant triple diagnosis-that is, mammography, ultrasound, and fine-needle aspiration cytology. The clinical question was variable: initial diagnosis of cancer, suspicion of recurrence, doubtful tumor extension, or search for a primary tumor. METHODS We performed a retrospective study of 118 procedures in 104 patients with a suggestion of breast cancer, either at initial presentation or after treatment (relapse), with an inconclusive triple diagnosis. Planar and tomographic imaging was performed after injection of (99m)Tc-labeled methoxyisobutylisonitrile ((99m)Tc-MIBI). Results were compared with histopathologic analysis (surgery or core biopsy) in 82 cases and with clinical and imaging follow-up in 36 cases. RESULTS Breast cancer was proven in 69 cases. SM-SPECT had a sensitivity of 88.4% and a specificity of 67%. Eleven cancers were detected by SPECT, although planar images were negative. SM-SPECT was more sensitive in patients scanned at initial presentation (95%) than in those with suspected recurrence (81%). SM-SPECT correctly evaluated multicentricity or bilaterality in 8 of 11 patients and resulted in an increased tumor size in 8 patients. Overall, SM-SPECT modified the patient management in 58 of 118 cases (49%): SM made the diagnosis of cancer in 30 cases with doubtful or discordant triple diagnosis and ruled out malignancy in 28 cases. CONCLUSION SM-SPECT is a useful complementary tool for the diagnosis and evaluation of disease extent in patients with an inconclusive triple diagnosis including fine-needle aspiration. The procedure altered the patient management in 49% of the population. These results must be confirmed in a prospective trial.
Early postnatal protein malnutrition impairs recognition memory in rats (Rattus norvegicus)

The initial period of postnatal life is critical for brain development in both rodents and humans. Protein malnutrition imposed during this period produces irreversible consequences that include structural, neurochemical, and functional changes in the central nervous system, leading to long-term alterations in behavioral and cognitive parameters, such as memory. In this work, previously malnourished rats were evaluated in recognition memory procedures. Male Wistar rats (n = 132) were given isocaloric diets that contained 6% (malnourished) or 16% (control) protein until 49 days of life. A nutritional recovery period with standard lab chow was imposed from 50 to 70 days of age when the experiments began. Four different procedures of recognition memory were conducted. The analysis showed that malnourished rats had lower body weight compared with control rats from the first week of life until the end of the experiments (p < .05). In the memory procedures, malnourished rats had lower recognition indices compared with controls (p < .05). Well-nourished rats had a tendency to direct their exploration toward novelty, whereas malnourished rats explored the objects in the same proportion, demonstrating that they did not recognize the novelty. Protein malnutrition imposed early in life is suggested to affect hippocampal formation, the development of which is concentrated during this developmental period, and thus impair memory consolidation.
Gender-Specific Effects of Genetic Variants within Th1 and Th17 Cell-Mediated Immune Response Genes on the Risk of Developing Rheumatoid Arthritis

The present study was conducted to explore whether single nucleotide polymorphisms (SNPs) in Th1 and Th17 cell-mediated immune response genes differentially influence the risk of rheumatoid arthritis (RA) in women and men. In phase one, 27 functional/tagging polymorphisms in C-type lectins and MCP-1/CCR2 axis were genotyped in 458 RA patients and 512 controls. Carriers of Dectin-2 rs4264222T allele had an increased risk of RA (OR = 1.47, 95%CI 1.10–1.96) whereas patients harboring the DC-SIGN rs4804803G, MCP-1 rs1024611G, MCP-1 rs13900T and MCP-1 rs4586C alleles had a decreased risk of developing the disease (OR = 0.66, 95%CI 0.49–0.88; OR = 0.66, 95%CI 0.50–0.89; OR = 0.73, 95%CI 0.55–0.97 and OR = 0.68, 95%CI 0.51–0.91). Interestingly, significant gender-specific differences were observed for Dectin-2 rs4264222 and Dectin-2 rs7134303: women carrying the Dectin-2 rs4264222T and Dectin-2 rs7134303G alleles had an increased risk of RA (OR = 1.93, 95%CI 1.34–2.79 and OR = 1.90, 95%CI 1.29–2.80). Also five other SNPs showed significant associations only with one gender: women carrying the MCP-1 rs1024611G, MCP-1 rs13900T and MCP-1 rs4586C alleles had a decreased risk of RA (OR = 0.61, 95%CI 0.43–0.87; OR = 0.67, 95%CI 0.47–0.95 and OR = 0.60, 95%CI 0.42–0.86). In men, carriers of the DC-SIGN rs2287886A allele had an increased risk of RA (OR = 1.70, 95%CI 1.03–2.78), whereas carriers of the DC-SIGN rs4804803G had a decreased risk of developing the disease (OR = 0.53, 95%CI 0.32–0.89). In phase 2, we genotyped these SNPs in 754 RA patients and 519 controls, leading to consistent gender-specific associations for Dectin-2 rs4264222, MCP-1 rs1024611, MCP-1 rs13900 and DC-SIGN rs4804803 polymorphisms in the pooled sample (OR = 1.38, 95%CI 1.08–1.77; OR = 0.74, 95%CI 0.58–0.94; OR = 0.76, 95%CI 0.59–0.97 and OR = 0.56, 95%CI 0.34–0.93). SNP-SNP interaction analysis of significant SNPs also showed a significant two-locus interaction model in women that was not seen in men. This model consisted of Dectin-2 rs4264222 and Dectin-2 rs7134303 SNPs and suggested a synergistic effect between the variants. These findings suggest that Dectin-2, MCP-1 and DC-SIGN polymorphisms may, at least in part, account for gender-associated differences in susceptibility to RA.
Ventromedial medulla: Pain modulation and beyond

The midbrain periaqueductal gray (PAG) and ventromedial medulla (VMM) are generally viewed as the core of an endogenous descending modulatory system. However, available data demonstrate that PAG and VMM do not specifically target nociceptive transmission and that activation of either structure affects numerous homeostatic physiological processes. Pseudorabies virus (PRV) is a useful tracer that is retrogradely and transynaptically transported. PRV injections into homeostatic effector organs invariably label VMM neurons, both serotonergic and nonserotonergic. Studies in anesthetized rats have implicated two types of nonserotonergic VMM neurons in nociceptive modulation: ON cells are thought to facilitate nociception and OFF cells to inhibit nociception. Yet, in the unanesthetized animal, the discharge of VMM neurons changes in response to innocuous stimuli and during situations unrelated to nociception. In particular, VMM cells appear to modulate the timing of micturition, with ON cells promoting the initiation of voiding and OFF cells promoting urine storage. VMM cells also modulate sensory transmission. During both micturition and sleep, OFF cells discharge and sensory responsiveness is depressed. In sum, the VMM is hypothesized to modulate spinal sensory, autonomic, and motor circuits in order to maintain homeostasis. J. Comp. Neurol. 493:2–8, 2005. © 2005 Wiley‐Liss, Inc.
A meta-analysis

Background: To comprehensively evaluate the treatment efficacy and safety of silymarin for patients with glucose/lipid metabolic dysfunction using a meta-analysis. Methods: A systematic literature search in PubMed, EMBASE and Cochrane Library databases was performed up to October 1, 2019. STATA 13.0 software was used to estimate pooled standardized mean difference (SMD) and 95% confidence interval (95% CI). Results: Sixteen studies involving 1358 patients were identified. Overall meta-analysis showed that compared with control, silymarin significantly reduced levels of fasting blood glucose (SMD: 1.27, 95% CI= [ 1.78, 0.76]; P< .001), homeostatic model assessment for insulin resistance (SMD: 0.41, 95% CI= [ 0.70, 0.12]; P= .005), hemoglobin A1c (SMD: 1.88, 95% CI= [ 2.57, 1.20]; P< .001), total cholesterol (SMD: 1.13, 95% CI= [ 1.82, 0.77]; P< .001), triglyceride (SMD: 0.37, 95% CI= [ 0.69, 0.05]; P= .025), low-density lipoprotein-cholesterol (SMD: 1.30, 95% CI= [ 1.93, 0.67]; P< .001), C-reactive protein (SMD: 0.63, 95% CI= [ 1.01, 0.27]; P= .001), and increased high-density lipoprotein-cholesterol (SMD: 0.17, 95% CI= [0.05, 0.29]; P= .005), but had no impacts on function indicators of liver and kidney (alanine transaminase, aspartate aminotransferase, creatinine phosphokinase, creatinine) and the complication rate. Subgroup analyses indicated that insulin (which was negative in overall analysis) was significantly decreased in patients undergoing silymarin monotherapy (SMD: 2.03, 95% CI= [ 3.03, 1.04]; P= .044) for more than 3 months (SMD: 0.01, 95% CI= [ 0.25, 0.24]; P= .035). Conclusion: Supplementation of silymarin may be effective and safe for the management of diabetes mellitus and hyperlipidemia. Abbreviations: ALT = alanine transaminase, AST = aspartate aminotransferase, CI = confidence interval, CPK = creatinine phosphokinase, CRP = C-reactive protein, DM = diabetes mellitus, FBG = fasting blood glucose, FBI = fasting blood insulin, HbA1c = hemoglobin A1c, HDL-C= high-density lipoprotein-cholesterol, HOMA-IR = homeostatic model assessment for insulin resistance, IL = interleukin, LDL-C = low-density lipoprotein-cholesterol, MDA = malondialdehyde, OR = odds ratio, PRISMA = Preferred Reporting Items for Systematic Review and Meta-analysis, RCT = randomized controlled trial, SMD = standardized mean difference, TC = total cholesterol, TG = triglyceride, TNF = tumor necrosis factor.
Effects of age on rapid ankle torque development.

BACKGROUND When balance is disturbed, often only fractions of a second are available in which to make the initial responses needed for its restoration. Abilities to develop joint torques rapidly may be critical to such responses. We undertook this study to quantify age effects among healthy adults in abilities to develop ankle joint torques rapidly. METHODS Ankle dorsiflexion (DF) and plantarflexion (PF) torque development during rapid isometric and during isokinetic (30, 60, 120, 180, and 240 deg/sec) exertions was assessed in 24 healthy young (mean age 23 years) and 24 healthy old adults (mean age 72 years). The effects of age, gender, and torque direction on the times needed to reach given torque magnitudes, maximum rates of isometric torque development (MRTD), and maximum isokinetic torques were examined. RESULTS The old adults required substantially more time to reach given torque magnitudes than the young adults. For example, the young and old females needed approximately 236 and 337 msec to develop 15 Nm of DF torque, of which 141 and 164 msec were reaction times. Isometric MRTD were 25 to 36% lower in the old than in the young adults. The age declines in isometric torque development time were associated with losses in maximum isometric strength. Maximum isokinetic torques developed by the old were 20 to 40% lower than those of young adults. The percent losses in isokinetic torques with age were independent of joint angular velocity for PF, but increased with velocity for DF. CONCLUSIONS We found substantial age declines in abilities of healthy old adults to rapidly develop ankle joint torques. The capacities of even healthy old adults to recover balance or to carry out other time-critical actions that require moderate-to-substantial strengths may be considerably degraded by these declines.
An Evaluation of the Use of Accredited Baseline Assessment Schemes in England

Baseline assessment (accredited through the Qualifications and Curriculum Authority [QCA]) became a statutory requirement from September 1998 for all main tained primary schools in England. Since that date, schools have been required to implement baseline assessment with all children within seven weeks of starting school (i.e. at about 4-5 years of age) unless a comparable recent assessment has been made. A survey of baseline assessment in local education authorities (LEAs), covering both providers of schemes and LEAs using 'bought in' schemes, was carried out in summer 2000. This was followed by a parallel survey of a random sample of schools and case studies of the operation of baseline assessment in 16 LEAs. Baseline assessment was generally viewed positively and regarded as working effectively by school and, in particular, by LEA personnel. Areas of concern focused on lack of training in the use to be made of the data by schools, weaknesses concerning validity and reliability, lack of parental involve.
Biracial Perception in Black and White: How Black and White Perceivers Respond to Phenotype and Racial Identity Cues

Objectives: This study investigates how racial identity and phenotypicality (i.e., racial ambiguity) shape the perception of biracial individuals in both White and Black perceivers. We investigated complex racial categorization and its downstream consequences, such as perceptions of discrimination. Method: We manipulated racial phenotypicality (Black or racially ambiguous) and racial identity (Black or biracial) to test these cues’ influence on Black and White race categorizations in a sample of both White (n = 145) and Black (n = 152) identified individuals. Results: Though racial identity and phenotypicality information influenced deliberate racial categorization, White and Black participants used the cues in different ways. For White perceivers, racial identity and phenotypicality additively influenced Black categorization. For Black perceivers, however, racial identity was only used in Black categorization when racial ambiguity was high. Perceived discrimination was related to White (but not Black) perceivers’ distribution of minority resources to targets, however Black categorization related to perceived discrimination for Black perceivers only. Conclusion: By demonstrating how Black and White individuals use identity and phenotype information in race perceptions, we provide a more complete view of the complexities of racial categorization and its downstream consequences.
Long-Term Fracture Resistance of Simulated Immature Teeth Filled with Various Calcium Silicate-Based Materials

Objective. The aim of this in vitro study was to evaluate the long-term fracture resistance of simulated human immature permanent teeth filled with BioAggregate™ (BA), mineral trioxide aggregate (MTA), and EndoSequence® Root Repair Material (ERRM). Material and Methods. 40 teeth, simulated to average root length of 13 ± 1 mm (Cvek's stage 3), were included in the study. The teeth were randomly divided into four groups: Group 1: DiaRoot® BA, Group 2: MTA-Plus™ (MTA-P), Group 3: MTA-Angelus (MTA-A), and Group 4: ERRM. The root canal filling materials were applied according to the manufacturers' instructions. After 24 months of incubation, the roots of the teeth were embedded in acrylic blocks and subjected to fracture testing. The resultant data were analyzed statistically by Kruskal-Wallis and Mann-Whitney U tests. Results. Mean (±SD) failure loads (MPa) were 20.46 ± 2.53 for BA, 18.88 ± 5.13 for MTA-P, 14.12 ± 1.99 for MTA-A, and 17.65 ± 4.28 for ERRM groups. BA group exhibited the highest and MTA-A group showed the lowest resistance to fracture. Significant differences in fracture resistance were found between the groups of BA and MTA-A (p < 0.001), MTA-P and MTA-A (p < 0.05), and ERRM and MTA-A (p < 0.05). Conclusion. Within the limitations of this study, data suggests that BA-filled immature teeth demonstrate higher fracture resistance than other groups at 24 months appearing to be the most promising material tested.
The Computer Determination of Learning Styles as an Aid to Individualized Computer-Based Training.

Most training materials are presented in a way which ignores differences in learning style. The purpose of this study was to investigate the development of a short, computer‐presented test of verbal‐imagery learning style, capable of incorporation into computer‐based training (CBT) packages. The test was validated by measuring its relationship to performance on textual and pictorial learning materials. The test consisted of pairs of words presented on the computer screen. It was anticipated that verbalizers would respond more quickly to pairs that could be answered through verbal associations, while imagers would do so on those which required the use of mental pictures. The sample consisted of 60 school students, aged approximately 13 years. There were equal numbers of males and females. The students were grouped in mathematics according to their previous performance in the subject. The performance of the lower ability group, who were typical of many trainees with lower levels of prior attainment, reveale.
The effects of situational variables on distance covered at various speeds in elite soccer

Abstract The aim of this study was to examine the effect of match location, quality of opposition, and match status on distance covered at various speeds in elite soccer. Twenty-seven Spanish Premier League matches played by a professional soccer team were monitored in the 2005–2006 season using a multiple-camera match analysis system. The dependent variables were the distance covered by players at different intensities. Data were analysed using a linear regression analysis with three independent variables: match status (i.e. whether the team was winning, losing or drawing), match location (i.e. playing at home or away), and quality of the opponents (strong or weak). The top-class players performed less high-intensity activity (>19.1 km · h−1) when winning than when they losing, but more distance was covered by walking and jogging when winning. For each minute winning, the distance covered at submaximal or maximal intensities decreased by 1 m (P<0.05) compared with each minute losing. For each minute winning, the distance covered by walking and jogging increased by 2.1 m (P<0.05) compared with each minute losing. The home teams covered a greater distance than away teams during low-intensity activity (<14.1 km · h−1) (P<0.01). Finally, the better the quality of the opponent, the higher the distance covered by walking and jogging. Our findings emphasize the need for match analysts and coaches to consider the independent and interactive effects of match location, quality of opposition, and match status during assessment of the physical component of football performance.