Miracle-dz/UniFAR-FTUs huggingface dataset:
Minireview: the OPG/RANKL/RANK system.

The identification of the OPG/RANKL/RANK system as the dominant, final mediator of osteoclastogenesis represents a major advance in bone biology. It ended a long-standing search for the specific factor produced by preosteoblastic/stromal cells that was both necessary and sufficient for osteoclast development. The initial cloning and characterization of OPG as a soluble, decoy receptor belonging to the TNF receptor superfamily was the first step that eventually led to an unraveling of this system. Soon thereafter, the molecule blocked by OPG, initially called OPG-ligand/osteoclast differentiating factor (ODF) and subsequently RANKL, was identified as the key mediator of osteoclastogenesis in both a membrane-bound form expressed on preosteoblastic/stromal cells as well as a soluble form. RANKL, in turn, was shown to bind its receptor, RANK, on osteoclast lineage cells. The decisive role played by these factors in regulating bone metabolism was demonstrated by the findings of extremes of skeletal phenotypes (osteoporosis vs. osteopetrosis) in mice with altered expression of these molecules. Over the past several years, work has focused on identifying the factors regulating this system, the signaling mechanisms involved in the RANKL/RANK pathway, and finally, potential alterations in this system in metabolic bone disorders, from the extremely common (i.e. postmenopausal osteoporosis) to the rare (i.e. familial expansile osteolysis).
AN INVESTIGATION OF THE RELATIONSHIP OF SPIRITUAL INTELLIGENCE AND RESILIENCE WITH ATTITUDE TO FEAR OF CHILDBIRTH IN PREGNANT WOMEN

BACKGROUND Fear of giving birth is defined as the negative perception of pregnant women about giving birth, which is related to two important psychological issues, spiritual intelligence and resilience. Therefore, this research was conducted with the aim of determining the relationship between spiritual intelligence and resilience with attitude to fear of childbirth in pregnant women. MATERIALS AND METHODS This analytical-cross sectional study was performed on 134 pregnant women referring to Shoushtar health centers in 2018. Samples were selected using a two-stage sampling (cluster-based method). The data collection tool was a demographic data form and standard SISRI questionnaire, Conner-Davidson Persistence (CD-RISC) and Hearman Maternity Fear (CAQ). Data was analysed using SPSS software version 16. The results were showed as descriptive statistics. RESULTS The results showed that resiliency with all components of spiritual intelligence was statistically significant (P <0.05). There was no significant difference between the variables of age and level of education with spiritual intelligence and resilience (P> 0.05). Also, there was a statistically significant relationship between resiliency and tendency to delivery type (normal / caesarean section) (P = 0.03). CONCLUSION Based on the results, there was a direct correlation between spiritual intelligence and resiliency. Therefore, it is suggested that the components of spiritual intelligence before delivery should be taught to pregnant women by health centers.
[Psychological gender in clinical depression. Preliminary study].

AIM Psychosocial and social theories of mood disorders indicate that factors connected with women's gender roles could create a higher risk of depression. The fact that social role is an important factor associated with depressive disorders suggests that not only a biological but also a psychological gender influences the vulnerability to depression. METHOD Gender schema theory was applied to investigate a role of femininity in depressive disorders. It was predicted that patients who identify themselves with the traditional feminine gender role will be more depressed than androgynous and undifferentiated patients or individuals with high level of masculinity. Sixty one patients suffering from affective disorder participated in this research. The Polish adaptation of Bem Sex - Role Inventory and Beck Depression Inventory were used to investigate the association between psychological gender and symptoms of depression. RESULTS The results indicated that there is a significant connection between the type of psychological gender and the level of depression. The highest level of depression was shown by undifferentiated patients, femininity was also found to be associated with a great number of depressive symptoms. These findings also suggest that androgynous individuals and patients with a high level of masculinity tend to be less depressed. CONCLUSIONS Psychological gender is an important factor which interacts to create a higher depression risk in men and women.
Dynamics of Person-to-Person Interactions from Distributed RFID Sensor Networks

Background Digital networks, mobile devices, and the possibility of mining the ever-increasing amount of digital traces that we leave behind in our daily activities are changing the way we can approach the study of human and social interactions. Large-scale datasets, however, are mostly available for collective and statistical behaviors, at coarse granularities, while high-resolution data on person-to-person interactions are generally limited to relatively small groups of individuals. Here we present a scalable experimental framework for gathering real-time data resolving face-to-face social interactions with tunable spatial and temporal granularities. Methods and Findings We use active Radio Frequency Identification (RFID) devices that assess mutual proximity in a distributed fashion by exchanging low-power radio packets. We analyze the dynamics of person-to-person interaction networks obtained in three high-resolution experiments carried out at different orders of magnitude in community size. The data sets exhibit common statistical properties and lack of a characteristic time scale from 20 seconds to several hours. The association between the number of connections and their duration shows an interesting super-linear behavior, which indicates the possibility of defining super-connectors both in the number and intensity of connections. Conclusions Taking advantage of scalability and resolution, this experimental framework allows the monitoring of social interactions, uncovering similarities in the way individuals interact in different contexts, and identifying patterns of super-connector behavior in the community. These results could impact our understanding of all phenomena driven by face-to-face interactions, such as the spreading of transmissible infectious diseases and information.
Schwann cells modulate short‐term plasticity of cholinergic autaptic synapses

Nicotinic synapses in the autonomous nervous system display use‐dependent plasticity but the contribution of cellular environment, as well as the presynaptic mechanisms implicated in this process remain to be determined. To address these questions synaptic function was assayed in rat superior cervical ganglion (SCG) neurons microcultured in isolation from any other cell type and compared to those microcultured in the presence of Schwann cells of ganglionar origin. Schwann cells were not required for synapse formation in vitro because functional cholinergic autaptic synapses were established in both experimental conditions. The number of synapses was comparable between the two culture conditions but the frequency of spontaneous miniature excitatory postsynaptic currents was enhanced in those neurons grown in direct contact with glial cells. Autapses displayed facilitation and depression, both processes being determined by the fraction of vesicles from the readily releasable pool discharged by an action potential. At high release probabilities vesicles were more efficiently mobilized, thus promoting depression, whilst low release probabilities made facilitation likely to occur. Schwann cells did not modify significantly facilitation but increased synaptic depression. In single cell microcultures, paired pulse stimuli showed a monoexponential recovery from depression with a time constant of ∼60 ms, while in microcultures developed together with glial cells, recovery was bi‐exponential with a significantly slower time course. Altogether these results show that Schwann cells from sympathetic ganglia directly modulate use‐dependent plasticity of nicotinic synapses in vitro by enhancing short‐term depression.
Impact of Foreign Exchange Interventions on Exchange Rate Expectations

Using monthly data for four selected emerging economies, we find that sterilised central bank foreign exchange intervention has little systematic influence on near-term nominal exchange rate expectations in the direction intended by the central banks. In other words, central bank dollar purchases to stem exchange rate appreciation or related exchange rate volatility are not associated with an adjustment of near-term exchange rate forecasts in the direction of depreciation, and vice versa. This suggests that intervention may not change near-term exchange rate expectations. Moreover, intervention may have unintended effects in the sense that it can lead to undesired volatility in the exchange rate, which is consistent with previous studies.Full publication: Market Volatility and Foreign Exchange Intervention in EMEs: What Has Changed?
Organizational Challenges for Innovation in Information Systems

In this paper, using the governance, resources and processes model for an organization, we examine the organizational challenges for innovation in information systems in each of the three areas of this model. Information systems are a great tool to support innovation to improve the processes and activities in an organization to achieve a competitive edge. We review the role of leadership (governance), intellectual capital (resources) and organizational culture (processes) on incremental and radical innovation in information systems. The existing research suggests that a democratic organizational culture fosters organizational learning and innovation whereas a hierarchical culture acts as a barrier. In information systems, the three phases of innovation include the concept, development and commercialization. The organizational challenges associated with the concept phase of the innovation in the information systems are reviewed. To explore the organizational challenges in the development and commercialization phases in terms of governance, resources and processes, a qualitative research proposal is presented.
The Conditions of ERP Implementation Projects: Evidence from Practice

This paper analyses the conditions of Enterprise Resource Planning (ERP) system implementations on the basis of research conducted among practitioners dealing with ERP projects. The study discusses how the researched projects were linked with enterprise strategy, how their efficiency was measured and in what extent they defined implementation goals. The investigated projects were divided into groups on the basis of their duration, scope, company size and success level achieved. The results demonstrate the real need for improvement as regards investigated conditions of ERP projects. The practitioners should be more focused on the business benefits during implementation project, elaborate the mechanisms in order to measure the implementation effectiveness and pay more attention to the definition of measurable implementation goals. The research outcome also reveals that practitioners from most complicated projects are most aware of the overwhelming implementation challenge, while, on the other hand, the relatively simpler projects seem to be underestimated.
Glucomannan- and glucomannan plus spirulina-enriched pork affect liver fatty acid profile, LDL receptor expression and antioxidant status in Zucker fa/fa rats fed atherogenic diets

ABSTRACT We evaluated the effects of glucomannan or glucomannan plus spirulina-restructured pork (RP) on liver fatty acid profile, desaturase/elongase enzyme activities and oxidative status of Zucker fa/fa rats for seven weeks. Control (C), glucomannan (G) and glucomannan/spirulina (GS)-RP; HC (cholesterol-enriched control), HG and HGS (cholesterol-enriched glucomannan and glucomannan/spirulina-RP) experimental diets were tested. Increased metabolic syndrome markers were found in C, G and GS rats. Cholesterol feeding increased liver size, fat, and cholesterol and reduced antioxidant enzyme levels and expressions. Cholesterolemia was lower in HG and HGS than in HC. GS vs. G showed higher stearic but lower oleic levels. SFA and PUFA decreased while MUFA increased by cholesterol feeding. The arachidonic/linoleic and docosahexaenoic/alpha-linolenic ratios were lower in HC, HG, and HGS vs. C, G, and GS, respectively, suggesting a delta-6-elongase-desaturase system inhibition. Moreover, cholesterol feeding, mainly in HGS, decreased low-density-lipoprotein receptor expression and the delta-5-desaturase activity and increased the delta-9-desaturase activity. In conclusion, the liver production of highly unsaturated fatty acids was limited to decrease their oxidation in presence of hypercholesterolaemia. Glucomannan or glucomannan/spirulina-RP has added new attributes to their functional properties in meat, partially arresting the negative effects induced by high-fat-high-cholesterol feeding on the liver fatty acid and antioxidant statuses.
Expression of pheromone binding proteins during antennal development in the gypsy moth Lymantria dispar

We have identified 2 olfactory specific proteins in the gypsy moth Lymantria dispar that are uniquely associated with the male antennae, the principal olfactory organs of this animal. These proteins were the major soluble protein components of the olfactory sensilla, present in equivalent amounts. Both proteins comigrated on SDS-PAGE, showing an apparent molecular mass of 15,000 Da but migrated separately on non-SDS- PAGE, indicating differences in net charge. N-terminal amino acid sequence analysis showed that the 2 proteins share 50% identity, indicating that they are genetically distinct homologs. Both proteins bound the L. dispar sexpheromone, associated with antisera prepared against the previously identified phermone-binding protein (PBP) of the moth Antheraea polyphemus, and shared sequence identity with the A. polyphemus PBP. These 2 proteins are therefore identified as L. dispar PBPs and are termed PBP1 and PBP2 based on their migration differences on non-SDS-PAGE. It is estimated that PBP1 and PBP2 are present in the sensilla lumen at a combined concentration of 13.4 mM. The expression of the L. dispar PBPs was examined during the 11 d development of the adult antenna. PBP1 and PBP2 were first detected by non-SDS-PAGE analysis and Coomassie blue staining 3 d before adult eclosion, on day A-3. Levels increased, reaching a plateau on day A-1 that continued into adult life. In vivo labeling studies indicated that the rate of PBP synthesis increased from A-3 to a plateau on A-2, where it remained into adult life. In vitro translations of antennal mRNAs indicated that translatable PBP mRNA was available at a very low level on day A-4, increased slightly on A-3 and dramatically on A-2, and remained at a high level into adult life. PBP mRNA represented the major translatable mRNA in the antenna during this period. It was estimated that the PBPs undergo a combined steady-state turnover of 8 x 10(7) molecules/hr/sensillum. Cursory in vivo and in vitro translation studies of antennal mRNA from A. polyphemus and Manduca sexta showed similar temporal patterns of PBP expression, suggesting that the L. dispar observations are general.
Labeling Theory and the Effects of Sanctioning on Delinquent Peer Association: A New Approach to Sentencing Juveniles

This is a review of contemporary theory and studies published in various scholarly journals regarding the labeling effect of criminal justice system involvement at a young age on offenders. Drawing on studies that have taken place over the past several decades in order to increase the generalizability of the conclusions, this paper discusses the relationship between formal sanctioning and delinquent peer association among offenders. Results from the studies lend support to the tenets of labeling theory. They also suggest that the relative rate of increased recidivism among offenders is positively correlated with an operationalized measure of their “stakes in conformity” (e.g. marriage, employment, civic involvement, etc.). This literature review highlights the need for a reassessment of current sentencing policy for juveniles, as their life-course orientation is particularly vulnerable to negative influences. More generally, this review brings together theory and data to call for a rejection of sentencing policies which claim to “get tough on crime. ”
GPS Navigation Using Three Satellites and a Precise Clock

Navigation using GPS generally requires that the user track four satellites to resolve his 3-D spatial position and time bias. There are several reasons why it is desirable to navigate while tracking only three satellites: —The proposed 18 satellite GPS constellation will exhibit substantial periods of poor four satellite geometry over large geographic areas several times a day. —Failure of a GPS satellite in orbit will result in periods of only three-satellite availability over large geographic areas. —During establishment of the operational GPS constellation, there will be long periods of three-satellite GPS coverage. Three-satellite GPS navigation can be accomplished by equipping the user with a precise clock. The required stability of the clock is a function of the maximum allowable PDOP (Position Dilution of Precision) and the time interval between updates of the clock. Clock updates can be accomplished by tracking four GPS satellites, tracking one GPS satellite from a known location, or conventional time transfer methods. This paper presents a formula for computing PDOP and its components, HDOP (Horizontal DOP) and VDOP (Vertical DOP), as a function of three-satellite geometry and clock stability. This formula is used to plot HDOP and VDOP versus time for representative high quality quartz crystal and low-cost rubidium clocks for two scenarios of satellite geometry. The stability and environmental sensitivity of high quality quartz crystal and low-cost rubidium clocks are discussed.
Vitamin K status is associated with childhood bone mineral content

In adult bone, vitamin K contributes to bone health, probably through its role as co-factor in the carboxylation of osteocalcin. In children, the significance of vitamin K in bone-mass acquisition is less well known. The objective of this longitudinal study was to determine whether biochemical indicators of vitamin K status are related to (gains in) bone mineral content (BMC) and markers of bone metabolism in peripubertal children. In 307 healthy children (mean age 11·2 years), BMC of the total body, lumbar spine and femoral neck was determined at baseline and 2 years later. Vitamin K status (ratio of undercarboxylated (ucOC) to carboxylated (cOC) fractions of osteocalcin; UCR) was also measured at both time points. Markers of bone metabolism, sex steroids, vitamin D status and growth hormones were measured at baseline only. Large variations in the levels of the UCR were found at both time-points, indicating a substantial interindividual difference in vitamin K status. Improvement of vitamin K status over 2 years (n 281 children) was associated with a marked increase in total body BMC (r − 49·1, P < 0·001). The UCR was associated with pubertal stage, markers of bone metabolism, sex hormones and vitamin D status. A better vitamin K status was associated with more pronounced increase in bone mass in healthy peripubertal children. In order to determine the significance of these findings for childhood bone health, additional paediatric studies are needed.
p-ERK1/2 is a predictive factor of response to erythropoiesis-stimulating agents in low/int-1 myelodysplastic syndromes

Serum erythropoietin level less than 100U/L and a transfusion requirement of less than 2 units per month are the best predictive factors for response to treatment by erythropoiesis-stimulating agents in low/int-1 myelodysplastic syndromes. To investigate the factors influencing the response to erythropoiesis-stimulating agents, we enrolled 127 low/int-1 myelodysplastic syndrome patients at diagnosis in a biological study of erythropoiesis. The 54 non-responders had a significantly lower number of burst-forming unit-erythroid and colony-forming unit-erythroid than responders. Erythropoietin-dependent proliferation and survival, and phospho (p)-ERK1/2 expression in steady state and after erythropoietin stimulation were defective in cultured erythroblasts. By flow cytometry, p-ERK1/2 was significantly lower in bone marrow CD45−/CD71+/GPA−cells from non-responders compared to responders or controls. Receiver Operator Characteristic curve analysis showed that this flow cytometry test was a sensitive biomarker for predicting the response to erythropoiesis-stimulating agents.
Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: a multicenter standardized study.

BACKGROUND Single-center trials have shown that monocytic HLA-DR is a good marker for monitoring the severity of temporary immunodepression after trauma, major surgery, or sepsis. A new test for measuring monocytic HLA-DR is now available. METHODS We evaluated a new test reagent set for monocytic HLA-DR expression (BD Quantibritetrade mark HLA-DR/Monocyte reagent; Becton Dickinson) in single-laboratory and interlaboratory experiments, assessing preanalytical handling, lyse-no-wash (LNW) vs lyse-wash (LW) values, reference values, and the effect of use of different flow cytometers and different instrument settings on test variance. RESULTS For preanalytical handling, EDTA anticoagulation, storage on ice as soon as possible, and staining within 4 h after blood collection gave results comparable to values obtained for samples analyzed immediately after collection (mean increase of approximately 4% in monocytic HLA-DR). Comparison of LNW and LW revealed slightly higher results for LNW ( approximately 18% higher for LNW compared with LW; r = 0.982). Comparison of different flow cytometers and instrument settings gave CVs <4%, demonstrating the independence of the test from these variables and suggesting that this method qualifies as a standardized test. CV values from the interlaboratory comparison ranged from 15% (blood sample unprocessed before transport) to 25% (stained and fixed before transport). CONCLUSIONS For the BD Quantibrite HLA-DR/Monocyte test, preanalytical handling is standardized. Single-laboratory results demonstrated the independence of this test from flow cytometer and instrument settings. Interlaboratory results showed greater variance than single-laboratory values. This interlaboratory variance was partly attributable to the influence of transport and can be reduced by optimization of transport conditions.