Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomedical Applications of Mesoporous Ceramics: Drug Delivery, Smart Materials and Bone Tissue Engineering

Biocompatible and Bioactive Mesoporous Ceramics General Properties of Ordered Mesoporous Ceramics Biodegradable and Bioactive Ceramics Calcium Phosphates Silica Organic Functionalization of Ordered Mesoporous Ceramics In Vitro Studies In Vivo Studies Mesoporous Ceramics as Drug Delivery Systems Adsorption of Biomolecules Release of Biomolecules Oral Drug Delivery Topical and Transdermal Drug Delivery Local Drug Delivery Targeted Drug Delivery Stimuli-Responsive Drug Delivery Systems Based on Mesoporous Silica pH as Release Trigger Temperature as Release Trigger Redox Potential as Release Trigger Light as Release Trigger Magnetic Field as Release Trigger Ultrasounds as Release Trigger Enzymes as Release Triggers Antigens as Release Triggers Aptamer Target as Release Trigger Dual Stimuli as Release Trigger Mesoporous Silica Nanoparticles in Nanomedicine Drug Delivery Targeting Gene Therapy Imaging Hyperthermia-Based Therapy Biosensing Theranostic Nanomedicine Biocompatibility and Toxicity Bone Tissue Regeneration Tissue Engineering Bone Tissue Engineering Biocompatibility of Ordered Mesoporous Silica
Do faster releases improve software quality? An empirical case study of Mozilla Firefox

Nowadays, many software companies are shifting from the traditional 18-month release cycle to shorter release cycles. For example, Google Chrome and Mozilla Firefox release new versions every 6 weeks. These shorter release cycles reduce the users' waiting time for a new release and offer better marketing opportunities to companies, but it is unclear if the quality of the software product improves as well, since shorter release cycles result in shorter testing periods. In this paper, we empirically study the development process of Mozilla Firefox in 2010 and 2011, a period during which the project transitioned to a shorter release cycle. We compare crash rates, median uptime, and the proportion of post-release bugs of the versions that had a shorter release cycle with those having a traditional release cycle, to assess the relation between release cycle length and the software quality observed by the end user. We found that (1) with shorter release cycles, users do not experience significantly more post-release bugs and (2) bugs are fixed faster, yet (3) users experience these bugs earlier during software execution (the program crashes earlier).
Outcomes Following an Early Parenting Center Residential Parenting Program

Outcomes for maternal well-being and behavior as well as difficult child behavior following participation in a 5-day early parenting center residential parenting program were explored. Participants were 44 mothers and their children, the majority presenting with child sleeping difficulties. Data were collected at four stages: intake (2-4 weeks prior to the program), the first day of the program, the last day of the program, and 4 weeks after the program. Measures included questionnaires, monitoring sheets, and videotaped observations of parent— child interactions. Improvements were seen in mothers’ behavior during parent—child interaction over the week they attended the program. Maternal symptoms of depression, anxiety, and stress were lower after the program. The perceived frequency and seriousness of maternal reported difficult child behavior decreased over the measurement period, and 52% of parents had achieved 80% or more of their behavioral goal for their children. Implications for future research in early parenting centers are discussed.
New HRM Practices, Complementarities, and the Impact on Innovation Performance

AbstractAlthough organisational structure has sometimes been mentioned in evolutionaryeconomics as well as in the innovation literature as a possible determinant of innovationperformance, very little systematic theoretical and empirical work exist on this issue. Inthis paper, we take our theoretical point of departure in recent work in organisationaleconomics and elsewhere, on systems of human resource management practices. We putand develop the argument that just as complementarities between new HRM practicespositively influence financial performance, they will also positively influence innovationperformance. We examine this overall hypothesis by estimating an empirical model ofinnovation performance, using data from a Danish survey of 1900 business firms. Usingprincipal components analysis we identify two HRM systems which are conducive toinnovation. The first is one in which all of our nine HRM variables matter (almost)equally for the ability to innovate. The second system, which is found to be conducive toinnovation is dominated by performance related pay and to some extent by firm-internaltraining. Of our total of nine sectors we find that the four manufacturing sectors correlatewith the first system, while also firms located in ICT intensive service sectors areassociated with the first system. Firms belonging to the wholesale trade sector tend to beassociated with the second system.JEL classification :C25, D23, O32KeywordsInnovation, human resource management practices, organisational complementarities,evolutionary economics.
Reinforcing a Matroid to Have k Disjoint Bases

Let denote the maximum number of disjoint bases in a matroid . For a connected graph , let , where is the cycle matroid of . The well-known spanning tree packing theorem of Nash-Williams and Tutte characterizes graphs with . Edmonds generalizes this theorem to matroids. In [1] and [2], for a matroid with , elements with the property that have been characterized in terms of matroid invariants such as strength and -partitions. In this paper, we consider matroids with , and determine the minimum of , where is a matroid that contains as a restriction with both and . This minimum is expressed as a function of certain invariants of , as well as a min-max formula. These are applied to imply former results of Haas [3] and of Liu et al. [4].
Metaplastic Carcinoma of the Breast : A Clinicopathologic Study of 29 Patients

The clinical and pathologic findings in 29 patients whose primary breast neoplasm manifested the microscopic pattern of spindle cell carcinoma or extensive squamous or pseudosarcomatous metaplasia were studied. In several of the tumors, the diagnosis of primary sarcoma or squamous cell carcinoma was excluded only after a prolonged search for evidence of invasive ductal carcinoma. The paucity of axillary lymph node metastases and the circumscription of these neoplasms belied their aggressive clinical behavior. The size of the neoplasm at the time of initial treatment best correlated with prognosis, since the majority of patients whose carcinoma was less than 4 cm in diameter pursued a favorable course. The lack of correlation of the microscopic pattern of these neoplasms with prognosis, as well as the presence of apparent overlapping microscopic findings, supports the concept that they are variants of a single entity.
Effects of arachidonate-enriched triacylglycerol supplementation on serum fatty acids and platelet aggregation in healthy male subjects with a fish diet

The changes in fatty acid composition of serum and in platelet aggregation induced by supplementation of arachidonate-enriched TAG were investigated in twenty-four healthy Japanese men in a double-blind, placebo-controlled study. The arachidonate-enriched TAG ingested was an edible oil, extracted and purified from a biomass of submerged fermented Mortierella alpina. Mean daily intake of fish and shellfish by subjects was 87·2 (se5·3) g/d, while dietary intakes of arachidonic acid (ARA) by the ARA group and placebo group were 175 (se12) and 179 (se13) mg/d, respectively. In the ARA group, after 2-week supplementation of 838 mg ARA/d, ARA concentration in serum phospholipids was increased from 9·6 (se0·4) to 13·7 (se0·4) g/100 g total fatty acids, and was significantly different from that in the placebo group (P < 0·001). This level was maintained for 4 weeks but returned to baseline level after a 4-week washout period. Linoleic acid concentration in serum phospholipids decreased from 19·2 (se0·8) to 16·3 (se0·6) g/100 g total fatty acids in the ARA group. Similarly, ARA content of serum TAG increased after ARA supplementation. Neither the EPA nor DHA content of serum phospholipids or TAG was altered by ARA supplementation. The platelet aggregation induced in platelet-rich plasma by adding adenosine diphosphate, collagen and ARA, physical characteristics of subjects, and biochemical parameters were unchanged throughout the test period. These findings suggest that ARA concentration in serum phospholipids and TAG can be safely increased by supplementation of arachidonate-enriched TAG oil.
Antinociceptive Interactions between Intrathecal Gabapentin and MK801 or NBQX in Rat Formalin Test

Antagonists for spinal N-methyl-D-aspartate (NMDA) and amino-hydroxy-methtyl-isoxazolepropionate (AMPA) receptors are effective in attenuating acute nociception or injury-induced hyperalgesia. The antinociception of spinal gabapentin is developed in injury-induced hyperalgesia without affecting acute nociception. The authors evaluated the effects of intrathecal gabapentin, NMDA antagonist (MK801) and AMPA antagonist (NBQX) in the formalin test which shows injury-induced hyperalgesia as well as acute pain. We further assessed the interactions between gabapentin and either MK801 or NBQX. Male Sprague-Dawley rats were implanted with intrathecal catheters. To evoke pain, 50 µL of 5% formalin solution was injected into the hindpaw. The interaction was investigated by a fixed dose analysis or an isobolographic analysis. MK801 and NBQX suppressed flinching responses during phase 1 of the formalin test, while gabapentin had little effect on phase 1. All three agents decreased the phase 2 flinching response. A fixed dose analysis in phase 1 showed that gabapentin potentiated the antinociceptive effect of MK801 and NBQX. Isobolographic analysis in phase 2 revealed a synergistic interaction after coadministration of gabapentin-MK801 or gabapentin-NBQX. Correspondingly, spinal gabapentin with NMDA or AMPA antagonist may be useful in managing acute pain and injury-induced hyperalgesia.
Numerical Evaluation of the Influence of Aggregates on Concrete Compressive Strength at High Strain Rate

The dynamic strength of concrete materials is usually obtained by conducting laboratory tests such as drop-weight test or split Hopkinson pressure bar (SHPB) test. It is widely accepted that the uniaxial compressive strength of concrete and concrete-like material increases with strain rate. Many empirical relations of concrete material dynamic increase factor (DIF), which are proposed for use in the design and analysis, are given in the literature. However, most of these empirical relations were obtained from testing data of concrete-like materials, i.e. the testing specimens were made of mortar matrix only without coarse aggregates owing to constraints in preparing the concrete specimens for high-speed impact tests. Because concrete is a composite material with mortar matrix, interfacial transition zone (ITZ) and aggregates, and these components have different material properties, using specimens made of mortar material alone in tests may not give accurate concrete dynamic material properties. It is also known that the lateral inertia confinement affects the dynamic strength of concrete specimens obtained in impact tests. A number of studies to investigate and quantify the lateral inertia confinement effect on dynamic strength of concrete materials obtained in impact tests have been published. Previous studies also indicate that including aggregates in concrete specimens affects the dynamic strength. However, no systematic study that devotes to investigating the influence of aggregates in concrete specimen on its dynamic strength has been reported yet. In the present study, a mesoscale concrete material model is used to simulate impact tests and to study the influences of aggregates on concrete material compressive strength increment at high strain rates. The commercial software AUTODYN is used to perform the numerical simulations. A method to remove the influence from lateral inertia confinement is proposed and verified. The influence of ITZ on compressive behavior of concrete specimen is discussed. Numerical simulations of concrete specimens with different volumetric percentages, e.g. 20% 30% and 40%, of aggregates under impact loads of different loading rates are carried out. The influence of the aggregates on DIF of concrete material is examined and quantified.
Absence of Nuclear p16 From Epstein‐Barr Virus‐Associated Undifferentiated Nasopharyngeal Carcinomas

Objective: Epstein‐Barr virus (EBV) is detected in the majority of undifferentiated nasopharyngeal carcinomas (UNPCs, World Health Organization type III). However, the exact mechanism involved in the carcinogenesis of EBV‐associated UNPCs remains to be elucidated. An important unresolved question is: how is the normal cell cycle deregulated during EBV‐associated UNPC development? The p16CDKN2 gene encodes a nuclear protein, p16, which inhibits the D‐type cyclin/cyclin‐dependent kinase complexes that phosphorylate the retinoblastoma gene product (pRb), thus blocking G1 cell cycle progression. The objective of this study was to determine whether p16 absence is involved in the development of EBV‐associated UNPCs.
Evidence for catastrophic volcanic debris flows in Pemberton Valley, British Columbia

The Mount Meager volcanic complex in southern British Columbia is snow and ice covered and has steep glaciated and unstable slopes of hydrothermally altered volcanic deposits. Three large-volume (>108 m3) volcanic debris flow deposits derived from the Mount Meager volcanic complex have been identified. The volcanic debris flows travelled at least 30 km downstream from the volcanic complex and inundated now populated areas of Pemberton Valley. Clay content and mineralogy of the deposits indicate that the volcanic debris flows were clay-rich (5%–7% clay in the matrix) and derived from hydrothermally altered volcanic material. The youngest volcanic debris flow deposit is interpreted to be associated with the last known volcanic eruption, ~2360 calendar (cal) years BP. The other two debris flows may not have been directly associated with eruptions. Volcanic debris flow hazard inundation maps have been produced using the Geographic Information System (GIS)-based modelling program, LAHARZ. The maps provide esti.
Dose-modifying factor for captopril for mitigation of radiation injury to normal lung

Our goal is to develop countermeasures for pulmonary injury following unpredictable events such as radiological terrorism or nuclear accidents. We have previously demonstrated that captopril, an angiotensin converting enzyme (ACE) inhibitor, is more effective than losartan, an angiotensin type-1 receptor blocker, in mitigating radiation-pneumopathy in a relevant rodent model. In the current study we determined the dose modifying factors (DMFs) of captopril for mitigation of parameters of radiation pneumonitis. We used a whole animal model, irradiating 9–10-week-old female rats derived from a Wistar strain (WAG/RijCmcr) with a single dose of irradiation to the thorax of 11, 12, 13, 14 or 15 Gy. Our study develops methodology to measure DMFs for morbidity (survival) as well as physiological endpoints such as lung function, taking into account attrition due to lethal radiation-induced pneumonitis. Captopril delivered in drinking water (140–180 mg/m2/day, comparable with that given clinically) and started one week after irradiation has a DMF of 1.07–1.17 for morbidity up to 80 days (survival) and 1.21–1.35 for tachypnea at 42 days (at the peak of pneumonitis) after a single dose of ionizing radiation (X-rays). These encouraging results advance our goals, since DMF measurements are essential for drug labeling and comparison with other mitigators.
Evaluating the Effects of Staking and Planting Dates on the Yields of African Yam Bean, Sphenostylis stenocarpa in Nigeria

Aims: To evaluate the effects of staking and planting dates on the seed/tuber yields of African yam bean (AYB). Study Design: The fields were laid out in split-plots in randomized complete block design Place and Duration: Field experiments were conducted at Ebonyi State University, Abakaliki, Nigeria during 2009/10 farming seasons. Methodology: Three different planting dates were used as the main-plot treatments, while staking and non-staking formed the sub-plots. Seven accessions of AYB were planted in the sub-plots. Five plants were randomly selected from each accession/treatment and tagged for data collection. Each seedling was staked independent after germination, while the non-staked plants were allowed to trail on the ground guided. Collected data were subjected to analyses of variance. Mean separation was carried out by Fisher’s protected LSD test. Pearson correlation coefficient (r) was used to determine the relationship between yields, planting dates and staking. Results : The results indicated that all the AYB accessions performed better when they were staked and planted earlier in May of each season with greater seed/tuber yields, which differed significantly (P < 0.028) from those that were not staked and planted later in each of the season. Of all the accessions assessed, TSs86 was the most productive with the highest seed yield and differed significantly (P < 0.015) from the rest except TSs48 that even gave better seed yield during 2010, while TSs84 had the least seed yields. Results on
Efficacy of the motor component of the Glasgow Coma Scale in trauma triage.

BACKGROUND National guidelines recommend that patients with Glasgow Coma Scale (GCS) scores of less than 14 be triaged to trauma centers. We hypothesized that the motor component of the GCS (GCSM) would be equally sensitive as the total GCS in head injury triage. METHODS A 2-year retrospective review of 3,235 injured adults transported directly to a Level I trauma center. RESULTS One thousand four hundred ten patients (44%) had prehospital GCS scores recorded. GCSM was found to have a sensitivity of 0.90 for Abbreviated Injury Scale (AIS) score = 5 head injury and 0.61 for AIS score > 3 injury, whereas the GCS had sensitivities of 0.92 and 0.62, respectively (p = not significant). Specificities were equal at 0.85 for AIS score = 5 and 0.89 for AIS score > 3. CONCLUSION GCSM is equivalent to GCS for prehospital triage, and in view of its simplicity it should replace the GCS in triage schemes.
Changes of renal sympathetic activity in acute and chronic conscious sinoaortic denervated rats.

The arterial pressure level attained in sinoaortic denervated rats depends on the net effect of eliminating excitatory and inhibitory influences (chemoreceptor and baroreceptor elimination, respectively). After sinoaortic denervation is completed, the hypertension usually observed within the first few days is followed by normotension at the chronic stages. In this work renal sympathetic nerve activity was measured in conscious, unrestrained rats 6 hours (acute) and 20 days (chronic) after sinoaortic denervation. Increased arterial pressure (154 +/- 10 versus 114 +/- 3 mm Hg in controls) and renal sympathetic nerve activity (32 +/- 5 versus 13 +/- 2 bars per cycle in controls) with no changes in heart rate (404 +/- 17 vs 380 +/- 26 beats per minute) were observed in rats with acute sinoaortic denervation. In rats with chronic sinoaortic denervation, arterial pressure (119 +/- 8 mm Hg) and renal sympathetic nerve activity (13 +/- 6 bars per cycle) returned to control levels. Bradycardiac and tachycardiac responses to changes in blood pressure were reduced to 88% and 89%, respectively, in rats with acute sinoaortic denervation and 76% and 74%, respectively, in rats with chronic sinoaortic denervation. The reflex control of renal sympathetic nerve activity after acute and chronic sinoaortic denervation showed an impairment of sympathoinhibition (0.13 +/- 0.02 and 0.25 +/- 0.1 bars per cycle, respectively, versus 0.9 +/- 0.17 bars per cycle in controls). Sympathoexcitatory responses also were impaired in rats with acute and chronic sinoaortic denervation (0.08 +/- 0.03 and 0.37 +/- 0.1 bars per cycle, respectively, compared with 0.98 +/- 0.2 bars per cycle in controls). (ABSTRACT TRUNCATED AT 250 WORDS)
The inhibition of mitochondrial respiration by inhalational anaesthetic agents.

The effects of halothane, methoxyflurane, trichloroethylene, and chloroform on the oxidation of nicotinamide adenine dinudeotide (NAD)-linked substrates by isolated rat liver mitochondria were investigated. All four agents inhibited NADH oxidation at concentrations that did not affect respiration with succinate as the substrate. The mean inhibitory concentrations (±SD) for the abolition of stimulation of state IV respiration by ADP were: halothane 0.84 mM (±0.10 mM), methoxyflurane 1.05 mM (±0.25 mM), trichloroethylene 1.11 mM (±0.26 mM), and chloroform 2.62 mM (±0.45 mM). The clinical relevance of this inhibition of electron transfer is discussed.
Genetic variants in matrix metalloproteinase genes as disposition factors for ovarian cancer risk, survival, and clinical outcome

Ovarian cancer is one of the leading female cancers in the United States. Challenges remain in early diagnosis of this deadly disease. Matrix metalloproteinases (MMPs) family genes are paradoxically involved in cancer promotion and suppression. We hypothesize that genetic variants in MMP genes are associated with ovarian cancer development, so they could be potential markers for ovarian cancer diagnosis and prognosis. In this study of 417 ovarian cancer cases and 417 healthy controls, we genotyped a comprehensive panel of 266 single nucleotide polymorphisms (SNPs) in 23 MMP genes and analysed their associations with ovarian cancer risk, overall survival and treatment response in ovarian cancer cases who received platinum‐based chemotherapy with surgery. In the analysis on 339 Caucasian cases and 349 Caucasian controls, 4 SNPs were significantly associated with cancer risk. The most significant association was observed for rs2292730 (OR = 2.03, 95% CI = 1.39–2.96, P = 0.0002). Classification and regression tree analysis identified four terminal nodes with differential risk of ovarian cancer. Thirty‐four SNPs were significantly associated with overall survival and four of which showed significant association with response to chemotherapy. Unfavourable genotype analysis of top SNPs on overall risk of death showed significant gene‐dosage effect, survival tree analysis differentiated patients into distinct risk groups based on their genetic profiles with median survival times (MSTs) ranging from 17.7 to 151.7 months. In conclusion, our results suggest that genetic variants in MMP pathway genes may modulate the risk and clinical outcomes of ovarian cancer, both individually and jointly. © 2013 Wiley Periodicals, Inc.