Miracle-dz/UniFAR-FTUs huggingface dataset:
The orthogonal-oblique bi-level model of the Outcome Questionnaire (OQ-45.2): Polish adaptation based on factor analysis.

UNLABELLED AIM : The aim of this project was to conduct the cross-cultural factorial validation of the Outcome Questionnaire (OQ-45.2) using the Polish population. METHODS Data were obtained from day-patients (n = 211), inpatients (n = 234), outpatients (n = 137) and non-patients (n = 426). Statistical analyses included: parallel analysis, exploratory factor analysis, confirmatory factor analysis, correlation analysis, criterion equivalence, clinical significance and reliable change index, and test-retest. RESULTS Statistical analyses provided the strongest support for the bi-level model of the total score, five orthogonal (subscales specific for the Polish OQ, i.e. Social Conflicts and Addictive Behaviors; and original yet modified subscales, i.e. Symptom Distress, Interpersonal Relations, and Social Role), and two oblique factors (Somatization and Anxiety, Social Role 2). The psychometric properties of the Polish OQ were found to be adequate and similar to the original American OQ and its international adaptations. Specific for the Polish OQ cut-off scores for clinical significance were established. The role of cultural differences and the passage of time in the process of the cross-cultural validation were elaborated upon. CONCLUSIONS The Polish version of the OQ 45-2 has been recognized as an instrument adequately measuring general functioning as well as specific areas of functioning of the individual (i.e. interpersonal relations; social role performance; social conflicts; symptom distress; somatization and anxiety; addictive behaviors). Results of this factorial analysis seem to be valuable for both clinicians using the OQ-45.2 and for creators of any psychotherapy outcome measure.
Computational Investigation of Effects of AMPA Receptor Desensitization on Synaptic Integration in Striatal Medium Spiny Neurons

The nucleus accumbens (NAcc) constitutes the major subdivision of the ventral striatum and it plays an important role in the reward circuit. It is also considered as the major site of action for many drugs of abuse. The principal neuronal cell type in the NAcc is the Medium Spiny Neuron (MSN), which is its primary output cell. MSNs perform a central role in sensorimotor processing by integrating many excitatory inputs located across their dendritic arbor to fire an action potential. Synaptic responses can summate linearly, sublinearly or supralinearly depending on the spatiotemporal pattern of activity. AMPA receptor (AMPAR) desensitization affects integration process. The effect of AMPAR desensitization is explored in modulating the temporal integration window for synaptic inputs in MSN. It seems to exert a major constraint on the integration window of the MSN such that action potentials are generated only when inputs are activated within a narrow latency, requiring greater synchrony of inputs for excitation. Key Wordsintegration, MSN, nucleus accumbens.
Server-side reconstruction trajectory generation methods for hand written objects authentication - A comparative review

In online applications, there is a foreseeable explosive growth in biometric personal authentication systems which are covenant with a measurable behavioral trait. Hand written object [HO] verification is the process used to recognize an individual, which is intuitive reliable indicator. Verification of a HO as a biometric modality still is a challenging field of research, as number of online and offline commercial applications use modern acquisition devices. The employment of HO verification with technology still remains open for novel methods due to inter-class and intra-class variations. This paper discusses the trajectory generation [TG] methods applicable for any HO verification, such as character recognition, handwriting verification, style classification, shape recognition and signature recognition, which are suitable for latest trend of mobile-commerce and web-commerce applications.
The Incorporation of Subject Knowledge in Teaching Scientific Translation

Scientific translation accounts for a big proportion of translation work currently commissioned by the industry. On the one hand, translation commissioners tend to rank specialized knowledge in a given subject area as more important than translation skills. On the other hand, the literature suggests that translator trainers rate subject knowledge as highly as linguistic skills. However, both the deductive and inductive approaches to teaching subject matter fail to prepare students for real-life translation work. Enlightened by the theory of social constructivism which sees learning as a social collaborative process, this paper discusses the importance of subject knowledge in translating science and technology and explores feasible ways to foster translation students? acquisition of subject knowledge in their learning of scientific translation. It is hoped that the study in this paper could shed some lights on further improvement of pedagogical practices in scientific translator education.
Fuel, Hydraulic Oil and Lubricant Consumption in Swedish Mechanized Harvesting Operations, 1996

Abstract When subjecting forest products to certification the total environmental load of wood harvesting machinery should also be assessed. In this study fuel hydraulic oil and lubricant consumption in harvesting operations in Sweden has been examined by using machine data acquired through a questionnaire. The objectives of the study were to assess the contractor and forest company owned harvesters’ and forwarders’ average oil consumption in practical harvesting operations in Sweden, ascertain if the ownership and size of the machines give different consumption figures and estimate the use of environmentally acceptable hydraulic oils as well as the amount of oil spilled outdoors. Diesel consumption was found to be 9351/1000 m3 ub for forwarders and 1 1671/1000 m3 ub for single-grip harvesters. Hydraulic, transmission and chainsaw oil consumption was significantly higher in forest company owned harvesters while no significant differences were observed among forwarders. Hydraulic oil spillage was estimated.
Model Limitations and Parameter-Estimation Methods for Agricultural Applications of Polarimetric SAR Interferometry

Application of polarimetric synthetic aperture radar interferometry to the retrieval of geophysical parameters from vegetated scenes is based on simple direct models of such scenes. The first part of this paper presents an analysis of the correspondence between these simple models, namely, the random volume over ground and the oriented volume over ground (OVoG), and experimental data from samples of two agricultural crops (maize and rice) acquired in controlled conditions. Although an overall agreement between model and data is clear, some discrepancies have been found as a consequence of two assumptions in the model formulation: vertical homogeneity of the vegetation volume and absence of multiple scattering effects inside the volume. This paper presents the shape and location of the visible region of the experimental coherences on the complex plane and compares it with the feasible region predicted by the model. This comparison has also pointed out the low sensitivity of the direct model to extinction coefficients. In the second part, two different strategies for a complete inversion (i.e., estimation of all model parameters) of the OVoG model are proposed and compared, using the same data set. The first one is based on a combination of geometrical and numerical approaches (genetic algorithms) and the second one on a dual-baseline configuration. In all cases, ground topography is accurately estimated, with a maximum error of 10 cm. Vegetation height estimates are accurate up to 30 cm, with some bands and baseline configurations providing errors below 15 cm. However, results obtained for the extinction coefficients are not stable with frequency and exhibit high variability.
The importance of framework residues H6, H7 and H10 in antibody heavy chains: experimental evidence for a new structural subclassification of antibody V(H) domains.

The N-terminal segment (FR-H1) of the heavy chain (V(H)) of antibodies shows significant conformational variability correlating with the nature of the amino acids H6, H7 and H10 (Kabat H9). In this study, we have established a causal relationship between the local sequence and the structure of this framework region and linked this relationship to important biophysical properties such as affinity, folding yield and stability. We have generated six mutants of the scFv fragment aL2, covering some of the most abundant amino acid combinations in positions H6, H7 and H10 (according to a new consensus nomenclature, Kabat H9). For the aL2 wild-type (w.t.) with the sequence 6(Q)7(P)10(A) and for two of the mutants, the X-ray structures have been determined. The structure of the triple mutant aL2-6(E)7(S)10(G) shows the FR-H1 backbone conformations predicted for this amino acid combination, which is distinctly different from the structure of the w.t, thus supporting our hypothesis that these residues determine the conformation of this segment. The mutant aL2-6(E)7(P)10(G) represents a residue combination not occurring in natural antibody sequences. It shows a completely different, unique structure in the first beta-strand of V(H), not observed in natural Fv fragments and forms a novel type of diabody. Two V(H) domains of the mutant associate by swapping the first beta-strand. Concentration-dependent changes in Trp fluorescence indicate that this dimerization also occurs in solution. The mutations in amino acids H6, H7 and H10 (Kabat H9) influence the dimerization behavior of the scFv and its thermodynamic stability. All the observations reported here have practical implications for the cloning of Fv fragments with degenerate primers, as well as for the design of new antibodies by CDR grafting or synthetic libraries.
A Study of Realtime Summarization Metrics

Unexpected news events, such as natural disasters or other human tragedies, create a large volume of dynamic text data from official news media as well as less formal social media. Automatic real-time text summarization has become an important tool for quickly transforming this overabundance of text into clear, useful information for end-users including affected individuals, crisis responders, and interested third parties. Despite the importance of real-time summarization systems, their evaluation is not well understood as classic methods for text summarization are inappropriate for real-time and streaming conditions. The TREC 2013-2015 Temporal Summarization (TREC-TS) track was one of the first evaluation campaigns to tackle the challenges of real-time summarization evaluation, introducing new metrics, ground-truth generation methodology and dataset. In this paper, we present a study of TREC-TS track evaluation methodology, with the aim of documenting its design, analyzing its effectiveness, as well as identifying improvements and best practices for the evaluation of temporal summarization systems.
Learning Temporal Features for Detection on Maritime Airborne Video Sequences Using Convolutional LSTM

In this paper, we study the effectiveness of learning temporal features to improve detection performance in videos captured by small aircraft. To implement this learning process, we use a convolutional long short-term memory (LSTM) associated with a pretrained convolutional neural network (CNN). To improve the training process, we incorporate domain-specific knowledge about the expected size and number of boats. We carry out three tests. The first searches the best sequence length and subsampling rate for training and the second compares the proposed method with a traditional CNN, a traditional LSTM, and a gated recurrent unit (GRU). The final test evaluates our method with the already published detectors in two data sets. Results show that in favorable conditions, our method’s performance is comparable to other detectors but, on more challenging environments, it stands out from other techniques.
Enhanced timing abilities in percussionists generalize to rhythms without a musical beat

The ability to entrain movements to music is arguably universal, but it is unclear how specialized training may influence this. Previous research suggests that percussionists have superior temporal precision in perception and production tasks. Such superiority may be limited to temporal sequences that resemble real music or, alternatively, may generalize to musically implausible sequences. To test this, percussionists and nonpercussionists completed two tasks that used rhythmic sequences varying in musical plausibility. In the beat tapping task, participants tapped with the beat of a rhythmic sequence over 3 stages: finding the beat (as an initial sequence played), continuation of the beat (as a second sequence was introduced and played simultaneously), and switching to a second beat (the initial sequence finished, leaving only the second). The meters of the two sequences were either congruent or incongruent, as were their tempi (minimum inter-onset intervals). In the rhythm reproduction task, participants reproduced rhythms of four types, ranging from high to low musical plausibility: Metric simple rhythms induced a strong sense of the beat, metric complex rhythms induced a weaker sense of the beat, nonmetric rhythms had no beat, and jittered nonmetric rhythms also had no beat as well as low temporal predictability. For both tasks, percussionists performed more accurately than nonpercussionists. In addition, both groups were better with musically plausible than implausible conditions. Overall, the percussionists' superior abilities to entrain to, and reproduce, rhythms generalized to musically implausible sequences.
Thermal and trapping phenomena assessment on AlGaN/GaN microwave power transistor

In this paper a systematic analysis of thermal and trapping behaviour of microwave power AlGaN/GaN HEMTs has been carried out through pulsed current-voltage (PIV) measurements and S parameters. It is shown that the thermal resistance of the device can be accurately determined provided that some assumptions on the trapping behaviour of the device are verified. The values obtained have been checked by three dimensional finite element (3D-FE) simulations with reasonable accuracy. Kink effects in the output characteristics have been analysed at different temperatures and it has been shown that they are more pronounced at ambient temperature. Finally the microwave behaviour of the device versus temperature has been assessed.
Correlation between the salivary Streptococcus mutans levels and dental caries experience in adult population of Chandigarh, India

Objectives: To determine the level of Streptococcus mutans (S. mutans) in adults of Chandigarh and to correlate the dental caries in these individuals with their S. mutans titers. Materials and Methods: Salivary levels of Streptococcus mutans, using Dentocult SM commercial kits were estimated in 200, 25-35 year old adults (males and females). Streptococcus mutans were detected in 87% of the study sample. Score 2, representing 10 5 -10 6 CFU/ml (Colony Forming Unit) of saliva was found to be most prevalent, i.e. in 80 of 200 adults, followed by score 1, depicting S mutans with <10 5 CFU/ml, in 56 of 200 adults and score 3, with bacterial titer >10 6 CFU/ml in 38 of 200 adults. Results: Dental caries, recorded using Møller′s index, was found to be maximum in individuals with score 3, followed by score 2,1 and 0, thereby showing a positive correlation of dental caries with increasing titers of S. mutans. This correlation was statistically highly significant in males with figures as 8.73 decayed surfaces at score 2 rising to 17.38 at score 3. The mean of DMFT was higher among females than in the males in the present study. Conclusion: The split up data in males and females, showed a positive association between caries experience and salivary S. mutans scores. The results of the study will serve as a baseline data for future planning of preventive programs in adults.
A TEST OF WORKER POLICING THEORY IN AN ADVANCED EUSOCIAL WASP, VESPULA RUFA

Abstract Mutual policing is an important mechanism for maintaining social harmony in group-living organisms. In some ants, bees, and wasps, workers police male eggs laid by other workers in order to maintain the reproductive primacy of the queen. Kin selection theory predicts that multiple mating by the queen is one factor that can selectively favor worker policing. This is because when the queen is mated to multiple males, workers are more closely related to queen's sons than to the sons of other workers. Here we provide an additional test of worker policing theory in Vespinae wasps. We show that the yellowjacket Vespula rufa is characterized by low mating frequency, and that a significant percentage of the males are workers' sons. This supports theoretical predictions for paternities below 2, and contrasts with other Vespula species, in which paternities are higher and few or no adult males are worker produced, probably due to worker policing, which has been shown in one species, Vespula vulgaris. Behavioral observations support the hypothesis that V. rufa has much reduced worker policing compared to other Vespula. In addition, a significant proportion of worker-laid eggs were policed by the queen.
Juvenile crime drop: What is happening with youth in Spain and why?

One of the most robust findings in criminology is the fall in crime rates throughout the Western world. However, there is still much to be learnt about this and its causes. This case study analyses the Spanish juvenile crime trends and tests the explanatory capacity of the sociodemographic hypotheses. We use aggregate data provided by the police and self-report data. Our analysis could be of interest in a worldwide debate on the crime drop. Demographic changes and the economic situation have little relevance in explaining the changes. However, public policies seem to have had a greater impact on crime trends. Furthermore, gender equality can be considered a possible explanatory factor.
Preclinical Evaluation of Engineered Oncolytic Herpes Simplex Virus for the Treatment of Neuroblastoma

Despite intensive research efforts and therapeutic advances over the last few decades, the pediatric neural crest tumor, neuroblastoma, continues to be responsible for over 15% of pediatric cancer deaths. Novel therapeutic options are needed for this tumor. Recently, investigators have shown that mice with syngeneic murine gliomas treated with an engineered, neuroattenuated oncolytic herpes simplex virus-1 (oHSV), M002, had a significant increase in survival. M002 has deletions in both copies of the γ134. 5 gene, enabling replication in tumor cells but precluding infection of normal neural cells. We hypothesized that M002 would also be effective in the neural crest tumor, neuroblastoma. We showed that M002 infected, replicated, and decreased survival in neuroblastoma cell lines. In addition, we showed that in murine xenografts, treatment with M002 significantly decreased tumor growth, and that this effect was augmented with the addition of ionizing radiation. Importantly, survival could be increased by subsequent doses of radiation without re-dosing of the virus. Finally, these studies showed that the primary entry protein for oHSV, CD111 was expressed by numerous neuroblastoma cell lines and was also present in human neuroblastoma specimens. We concluded that M002 effectively targeted neuroblastoma and that this oHSV may have potential for use in children with unresponsive or relapsed neuroblastoma.
Crystallographic Studies Evidencing the High Energy Tolerance to Disrupting the Interface Disulfide Bond of Thioredoxin 1 from White Leg Shrimp Litopenaeus vannamei

Thioredoxin (Trx) is a small 12-kDa redox protein that catalyzes the reduction of disulfide bonds in proteins from different biological systems. A recent study of the crystal structure of white leg shrimp thioredoxin 1 from Litopenaeus vannamei (LvTrx) revealed a dimeric form of the protein mediated by a covalent link through a disulfide bond between Cys73 from each monomer. In the present study, X-ray-induced damage in the catalytic and the interface disulfide bond of LvTrx was studied at atomic resolution at different transmission energies of 8% and 27%, 12.8 keV at 100 K in the beamline I-24 at Diamond Light Source. We found that at an absorbed dose of 32 MGy, the X-ray induces the cleavage of the disulfide bond of each catalytic site; however, the interface disulfide bond was cleaved at an X-ray adsorbed dose of 85 MGy; despite being the most solvent-exposed disulfide bond in LvTrx (~50 Å2). This result clearly established that the interface disulfide bond is very stable and, therefore, less susceptible to being reduced by X-rays. In fact, these studies open the possibility of the existence in solution of a dimeric LvTrx.
Vaccination against Chlamydial Genital Tract Infection after Immunization with Dendritic Cells Pulsed Ex Vivo with Nonviable Chlamydiae

Chlamydia trachomatis, an obligate intracellular bacterial pathogen of mucosal surfaces, is a major cause of preventable blindness and sexually transmitted diseases for which vaccines are badly needed. Despite considerable effort, antichlamydial vaccines have proven to be elusive using conventional immunization strategies. We report the use of murine bone marrow–derived dendritic cells (DC) pulsed ex vivo with killed chlamydiae as a novel approach to vaccination against chlamydial infection. Our results show that DC efficiently phagocytose chlamydiae, secrete IL-12 p40, and present chlamydial antigen(s) to infection sensitized CD4+ T cells. Mice immunized intravenously with chlamydial-pulsed DC produce protective immunity against chlamydial infection of the female genital tract equal to that obtained after infection with live organisms. Immunized mice shed ∼3 logs fewer infectious chlamydiae and are protected from genital tract inflammatory and obstructive disease. Protective immunity is correlated with a chlamydial-specific Th1-biased response that closely mimics the immune response produced after chlamydial infection. Thus, ex vivo antigen-pulsed DC represent a powerful tool for the study of protective immunity to chlamydial mucosal infection and for the identification of chlamydial protective antigens through reconstitution experiments. Moreover, these findings might impact the design of vaccine strategies against other medically important sexually transmitted diseases for which vaccines are sought but which have proven difficult to develop.
Bmc Cell Biology Upregulation of Toll-like Receptor (tlr) Expression and Release of Cytokines from P815 Mast Cells by Gm-csf

Backgroud: Recently, mast cells have been recognized to express several Toll-like receptors (TLRs) on their membrane surfaces, and granulocyte-macrophage colony-stimulating factor (GM-CSF) was reported to be able to alter expression of TLRs and cytokine production in neutrophils. However, whether GM-CSF modulates the expression of TLR and cytokine production in mast cells is not clear. Results: Using flow cytometry and real time PCR techniques, we found that GM-CSF upregulated expression of TLR3 and TLR7 in P815 cells in a concentration dependent manner. GM-CSF also provoked approximately up to 2.4 and 2.3 fold increase in IL-13 and IL-6 release from P815 cells, respectively following 16 h incubation. GM-CSF induced IL-13 secretion, TLR3 and TLR7 expression appeared to be through activation of mitogen-activated protein kinase (MAPK) and phosphotidylinositol 3-kinase (PI3K)/Akt signaling pathways, whereas GM-CSF elicited IL-6 release seemed via Akt signaling pathway. At 10 ng/ml, GM-CSF significantly enhanced R-848-induced IL-6 release from P815 cells.