Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone response to buccal tooth movements-with and without flapless alveolar decortication.

SUMMARY OBJECTIVE To evaluate the biological response of alveolar bone surrounding maxillary second premolars to flapless alveolar decortication and moderate, continuous forces in a buccal direction. MATERIALS AND METHODS Using a randomized split-mouth experimental design, unilateral alveolar decortication was performed with a piezosurgery unit around the maxillary second premolars of six female dogs. The contralateral side received a sham surgery. The maxillary second premolars were moved buccally with archwires (initial 163.9 cN expansive force) for 9 weeks, followed by 2 weeks of consolidation. Intraoral, radiographic, and model measurements were performed to evaluate tooth movements; the amount and quality of surrounding bone were quantified using micro-CT; bone formation was evaluated histologically. RESULTS The experimental premolars were expanded and tipped significantly (P < 0.05) more than the control premolars (1.35 times and 2.05 times as much, respectively). Peak rates of tooth movement occurred around 5 weeks. Dehiscenses were observed on both the experimental and control sides, with no statistically significant side differences in buccal bone height (BBH). Micro-CT analyses showed less mature bone in the apico-buccal and cervico-lingual regions around the experimental teeth. Hematoxylin and eosin sections demonstrated fenestrations on the cervico-buccal bone on both sides. The experimental side showed substantially more new bone formation and modeling of apico-buccal, cervico-lingual, and buccal bone than the control side. CONCLUSIONS Archwire expansion resulted in reductions in BBH. Piezosurgical flapless alveolar decortication, in combination with archwire expansion, increased tooth movements and tipping and produced less bone, less dense bone, and less mature bone.
Infant feeding and weaning practices in Roman Egypt.

Current knowledge of infant feeding and weaning practices during the Roman period in Egypt is limited to scanty documentary and iconographic evidence. Stable nitrogen and carbon isotope analysis provides another avenue to explore this question. A sample of 49 infant and juvenile human skeletal remains from the Kellis 2 cemetery in the Dakhleh Oasis, Egypt, was used to determine patterns of infant feeding and weaning. delta(15)N values indicate that supplementary foods were introduced at around 6 months of age, and that weaning was complete by 3 years of age. By 6 months of age, delta(13)C values become increasingly enriched over adult values, and reach peak enrichment at approximately 1.5 years of age. Beyond this age, delta(13)C gradually declines to approach adult values. This enrichment in infant delta(13)C values is indicative of consumption of (13)C-enriched supplementary foods. Based on isotopic study of faunal and botanical remains from the ancient village of Kellis, we conclude that at approximately 6 months of age, infants were fed milk of goat and/or cow.
Circulating 25-Hydroxyvitamin D3 and Survival after Diagnosis with Kidney Cancer

Prospective cohort studies have provided some evidence that circulating vitamin D is associated with risk of, and survival from, renal cell carcinoma (RCC), but it is unclear whether concentrations of vitamin D at the time of diagnosis of RCC are associated with prognosis. We conducted a case–cohort study of 630 RCC cases, including 203 deaths, from a multicenter case–control study in Eastern Europe. Vitamin D was assessed as 25-hydroxyvitamin D3 [25(OH)D3], and we used weighted Cox models to estimate hazard ratios (HR) and 95% confidence intervals (CI) by categories of season-adjusted 25(OH)D3. Higher concentrations of 25(OH)D3 were associated with lower risk of death after adjusting for stage, age, sex, and country (HR highest vs. lowest category 0.57; 95% CI, 0.34–0.97). The inverse associations of 25(OH)D3 with death were most notable among those who died from non-RCC causes and those diagnosed with early-stage disease. In summary, 25(OH)D3 concentration at diagnosis of RCC was inversely associated with all-cause mortality rates, but not specifically with RCC outcome. Cancer Epidemiol Biomarkers Prev; 24(8); 1277–81. ©2015 AACR.
An Optimal Algorithm for Reconstructing Point Set Order Types from Radial Orderings

Let $P$ be a set of $n$ labeled points in the plane. The radial system of $P$ describes, for each $p\in P$, the order in which a ray that rotates around $p$ encounters the points in $P \setminus \{p\}$. This notion is related to the order type of $P$, which describes the orientation (clockwise or counterclockwise) of every ordered triple in $P$. Given only the order type, the radial system is uniquely determined and can easily be obtained. The converse, however, is not true. Indeed, let $R$ be the radial system of $P$, and let $T(R)$ be the set of all order types with radial system $R$ (we define $T(R) = \emptyset$ for the case that $R$ is not a valid radial system). Aichholzer et al. (Reconstructing Point Set Order Types from Radial Orderings, in ISAAC 2014) show that $T(R)$ may contain up to $n-1$ order types. They also provide polynomial-time algorithms to compute $T(R)$ when only $R$ is given. We describe a new algorithm for finding $T(R)$. The algorithm constructs the convex hulls of all possible point sets with the radial system $R$. After that, orientation queries on point triples can be answered in constant time. A representation of this set of convex hulls can be found in $O(n)$ queries to the radial system, using $O(n)$ additional processing time. This is optimal. Our results also generalize to abstract order types.
Impact of Gluten-Friendly Bread on the Metabolism and Function of In Vitro Gut Microbiota in Healthy Human and Coeliac Subjects

The main aim of this paper was to assess the in vitro response of healthy and coeliac human faecal microbiota to gluten-friendly bread (GFB). Thus, GFB and control bread (CB) were fermented with faecal microbiota in pH-controlled batch cultures. The effects on the major groups of microbiota were monitored over 48 h incubations by fluorescence in situ hybridisation. Short-chain fatty acids (SCFAs) were measured by high-performance liquid chromatography (HPLC). Furthermore, the death kinetics of Lactobacillus acidophilus, Bifidobacterium animalis subsp. lactis, Staphylococcus aureus, and Salmonella Typhimurium in a saline solution supplemented with GFB or CB were also assessed. The experiments in saline solution pinpointed that GFB prolonged the survival of L. acidophilus and exerted an antibacterial effect towards S. aureus and S. Typhimurium. Moreover, GFB modulated the intestinal microbiota in vitro, promoting changes in lactobacilli and bifidobacteria members in coeliac subjects. A final multivariate approach combining both viable counts and metabolites suggested that GFB could beneficially modulate the coeliac gut microbiome; however, human studies are needed to prove its efficacy.
Mapeo de la recuperación de la vegetación quemada mediante la clasificación de índices espectrales pre- y post-incendio

Este trabajo analizo el estado de recuperacion de la vegetacion del Parque Nacional Torres del Paine, incendiada entre Diciembre de 2011 y Marzo de 2012. El calculo y comparacion del NDVI (normalized difference vegetation index) del area afectada a lo largo de una serie temporal de 24 imagenes Landsat adquiridas antes, durante y despues del incendio (2009-2015), permitio apreciar la variacion temporal en los niveles de biomasa de la vegetacion afectada. La posterior clasificacion y comparacion de los indices espectrales NDVI, NBR (normalized burnt ratio) y NDWI (normalized difference water index), en un par de imagenes pre- y post-incendio con disponibilidad de datos completos y fenologicamente compatibles (adquiridas en Octubre de 2009 y 2014), permitio analizar y mapear el estado de recuperacion de la vegetacion afectada. Los resultados muestran que el area de las dos clases inferiores de todos los indices espectrales de la fecha pre-incendio paso a ser la mas dominante en la fecha post-incendio. El cruce de clases de NDVI pre- y post-incendio mediante una matriz de error evidencio que la clase mas alta y prevaleciente de NDVI pre-incendio, correspondiente en su mayor parte a bosque higromorfico y matorral preandino, se torno la clase mas baja en 2014. El resto del area de estudio, compuesta principalmente por estepa patagonica, restablecio sus niveles de biomasa en 2014, exhibiendo en gran medida las mismas clases de NDVI pre-incendio. Estos resultados podrian proveer directrices para el monitoreo y manejo de la regeneracion de la vegetacion impactada por este incendio.
Authoring Adaptive 3D Virtual Learning Environments

The use of 3D and Virtual Reality is gaining interest in the context of academic discussions on E-learning technologies. However, the use of 3D for learning environments also has drawbacks. One way to overcome these drawbacks is by having an adaptive learning environment, i.e., an environment that dynamically adapts to the learner and the activities that he performs in the environment. In this paper, the authors discuss adaptive 3D virtual leaning environments and explain how a course author can specify such an environment i.e., authoring. The approach and tool that the authors present allow authors to create adaptive 3D virtual learning environments without the need to be an expert in 3D or using programming or scripting languages. The authors also conducted an evaluation to validate the approach and the usability and acceptability of the authoring tool. Based on the results, recommendations for authoring adaptive 3D virtual learning environments have been formulated.
A quantitative Gibbard-Satterthwaite theorem without neutrality

Recently, quantitative versions of the Gibbard-Satterthwaite theorem were proven for k=3 alternatives by Friedgut, Kalai, Keller and Nisan and for neutral functions on k ≥ 4 alternatives by Isaksson, Kindler and Mossel.We prove a quantitative version of the Gibbard-Satterthwaite theorem for general social choice functions for any number k ≥ 3 of alternatives. In particular we show that for a social choice function f on k ≥ 3 alternatives and n voters, which is ε-far from the family of nonmanipulable functions, a uniformly chosen voter profile is manipulable with probability at least inverse polynomial in n, k, and ε−1.Ours is a unified proof which in particular covers all previous cases established before. The proof crucially uses reverse hypercontractivity in addition to several ideas from the two previous proofs. Much of the work is devoted to understanding functions of a single voter, and in particular we also prove a quantitative Gibbard-Satterthwaite theorem for one voter.
A Probabilistic Proof of the Rogers–Ramanujan Identities

The asymptotic probability theory of conjugacy classes of the finite general groups leads to a probability measure on the set of all partitions of natural numbers. A simple method of understanding these measures in terms of Markov chains is given in this paper, leading to an elementary probabilistic proof of the Rogers–Ramanujan identities. This is compared with work on the uniform measure. The main case of Bailey's lemma is interpreted as finding eigenvectors of the transition matrix of a Markov chain. It is shown that the viewpoint of Markov chains extends to quivers.
Ultrasonographic imaging of papillary thyroid carcinoma variants

Ultrasonography (US) is routinely used to evaluate thyroid nodules. The US features of papillary thyroid carcinoma (PTC), the most common thyroid malignancy, include hypoechogenicity, spiculated/microlobulated margins, microcalcifications, and a nonparallel orientation. However, many PTC variants have been identified, some of which differ from the classic type of PTC in terms of biological behavior and clinical outcomes. This review describes the US features and clinical implications of the variants of PTC. With the introduction of active surveillance replacing immediate biopsy or surgical treatment of indolent, small PTCs, an understanding of the US characteristics of PTC variants will facilitate the individualized management of patients with PTC.
Melatonin modulates allergic lung inflammation

Asthma is an inflammatory lung disease characterized by cell migration, bronchoconstriction and hyperresponsiveness, and can be induced, as an experimental model, by ovalbumin sensitization followed by a challenge. In addition to the well‐known immunostimulatory effects of melatonin, research has identified some of its anti‐inflammatory properties. In this study, we evaluated the influence of pinealectomy and melatonin administration on cell migration in an experimental model of allergic airway inflammation. We evaluated, in pinealectomized rats treated or not with melatonin, cell migration into the bronchoalveolar fluid, the number of cells and their proliferative activity in the bone marrow, and plasma corticosterone levels. Pinealectomy reduces, 24 hr after the challenge, the total cell number count in the lung and bone marrow cell proliferation, without changing the number of cells in the bone marrow or in the peripheral blood. This fact suggests that melatonin is important in the control of cell recruitment from the bone marrow and the migration of those cells to the lung. Melatonin administration to pinealectomized rats seems to restore the ability of cells to migrate from the bone marrow to the bronchoalveolar fluid. So, the development of specific inhibitors of melatonin would benefit patients with asthma.
Declarative Access Control for WebDSL: Combining Language Integration and Separation of Concerns

In this paper, we present the extension of WebDSL, a domain-specific language for web application development, with abstractions for declarative definition of access control. The extension supports the definition of a wide range of access control policies concisely and transparently as a separate concern. In addition to regulating the access to pages and actions, access control rules are used to infer navigation options not accessible to the current user, preventing the presentation of inaccessible links. The extension is an illustration of a general approach to the design of domain-specific languages for different technical domains to support separation of concerns in application development, while preserving linguistic integration. This approach is realized by means of a transformational semantics that weaves separately defined aspects into an integrated implementation.
Association between travel distance and metastatic disease at diagnosis among patients with colon cancer.

PURPOSE Health care access and advanced cancer stage are associated with oncologic outcomes for numerous common cancers. However, the impact of patient travel distance to health care on stage at diagnosis has not been well characterized. METHODS This study used a historical cohort of patients with colon cancer in the National Cancer Data Base from 2003 through 2010. The primary outcome, stage at diagnosis, was evaluated using hierarchical regression modeling. A secondary outcome was time to receipt of initial therapy that was evaluated using Cox shared frailty modeling. RESULTS Among 296,474 patients with colon cancer (mean age, 68 ± 13.6 years; 47.6% male; 78.5% white), 3.9% traveled ≥ 50 miles to the diagnosing facility. Fewer black patients, patients with higher income, and patients with lower education traveled longer distances (trend test P < .001 for all). Patients traveling ≥ 50 miles were more likely to present with metastatic disease compared with those traveling less than 12.5 miles (odds ratio [OR], 1.18; 95% CI, 1.12 to 1.24) or 12.5 to 49.9 miles (OR, 1.18; 95% CI, 1.12 to 1.24). In sensitivity analyses, the association was robust to alternate methods of modeling travel distance (quintile stratification or continuous). Travel distance ≥ 50 miles was also associated with a higher likelihood of earlier initiation of therapy compared with travel distance of less than 12.5 miles (hazard ratio [HR], 1.10; 95% CI, 1.08 to 1.13) or 12.5 to 49.9 miles (HR, 1.11; 95% CI, 1.08 to 1.13). CONCLUSION Advanced colon cancer stage at diagnosis is associated with patient travel distance to health care, which may be a barrier to early cancer screening. Health care reform efforts designed to address only insurance coverage may not mitigate disparities based on difficulties accessing cancer care.
A RIO-like technique for interactivity loss-avoidance in fast-paced multiplayer online games

The astonishing increase in the spread of the Internet has given rise to a globally connected community proficient at deploying online games for a large number of participants geographically located very far from each other. However, online games are characterized by more stringent requirements than traditional distributed applications deployed over the Internet can fulfill. Indeed, one of the key factors in determining the success of an online game is its ability to rapidly deliver events to the various game servers that maintain the state of the game over the network. We have already demonstrated [Palazzi et al. 2004] that in this context adapting RED (random early detection) techniques, borrowed from queuing management, can improve the global responsiveness of a game. However, this solution may not be sufficient for a specific class of online games. We deem that fast-paced multiplayer online games (such as shoot 'em ups, for example) in which participants have to behave frenetically, must guarantee a very high degree of interactivity, even at the cost of partially sacrificing the consistency of the game state. In this case having only a partially consistent view of the game state will not affect a player's amusement as much as delaying action-processing activity will. Hence we explore the possibility of applying a RIO-based (RED with in and out) algorithm to manage game delivery to the various game servers, in order to improve the degree of interactivity for fast-paced online games. Preliminary experimental results confirm the viability of our approach.
Applications of Finsler Geometry to Speed Limits to Quantum Information Processing

We are interested in fundamental limits to computation imposed by physical constraints. In particular, the physical laws of motion constrain the speed at which a computer can transition between well-defined states. Here, we discuss speed limits in the context of quantum computing. We review some relevant parts of the theory of Finsler metrics on Lie groups and homogeneous spaces such as the special unitary groups and complex projective spaces. We show how these constructions can be applied to analysing the limit to the speed of quantum information processing operations in constrained quantum systems with finite dimensional Hilbert spaces of states. We demonstrate the approach applied to a spin chain system.
Tailored cancer immunotherapy using combinations of chemotherapy and a mixture of antibodies against EGF-receptor ligands

Growth factors are implicated in several processes essential for cancer progression. Specifically, growth factors that bind to ErbB family receptors have been implicated in cell proliferation and in resistance of solid tumors to chemotherapy. We quantified ligand secretion by several human cancer cell lines, and generated mAbs against two ligands, namely TGF-α and heparin-binding EGF-like growth factor. These growth factors are frequently secreted by pancreatic tumor cell lines, including BxPC3 cells. The monoclonal antibodies were tested for their antigen specificity and ability to inhibit growth of BxPC3 cells in vitro. Combining the two antibodies resulted in enhanced inhibition of BxPC3 cell growth, both in vitro and in tumor-bearing animals. Hence, we combined the two antibodies with gemcitabine, an effective chemotherapeutic drug commonly used to treat pancreatic cancer patients. Because treatment with a combination of two monoclonal antibodies enhanced the ability of chemotherapy to inhibit BxPC3 tumors in mice, we propose a general cancer therapeutic strategy that entails profiling the repertoire of growth factors secreted by a tumor, and combining with chemotherapy several antibodies capable of blocking autocrine ligands.
A population-based study on tobacco consumption in urban slums: Its prevalence, pattern, and determinants

Background: India suffers from a huge burden of substance abuse and associated morbidity and mortality. Among all substance use, tobacco consumption is the most common and yet the most widely accepted one. This study aimed to estimate the prevalence of tobacco consumption, to find out the type of tobacco products used and to assess the factors influencing tobacco consumption in the slums of Shillong city. Materials and Methods: A cross-sectional, community-based study was carried out in 330 respondents aged 15 and above. Chi-square test was used to compare proportions, and Student's t-test was used to compare groups for continuous variables. Results: The prevalence of current tobacco consumption was found to be 73.9%, and the rate of quitting was found to be 4.3%. The prevalence of tobacco consumption was observed to be higher in males (52.4%) compared to 21.5% in females. Highly significant statistical association was observed between tobacco consumption and age, gender, and occupation. The statistical association between tobacco consumption and religion and education was found to be statistically significant. Ever use of tobacco in any form as well as smokeless form peaked in 24–34 years, while smoking was more prevalent among 15–24 year olds. The prevalence of smokeless tobacco was higher (47.5%) as compared to the prevalence of smoking (28.2%), closely followed by dual use (24.3%). The most popular smoked and smokeless forms were found to be cigarettes and khaini, respectively. Conclusions: Tobacco consumption was found to be highly prevalent and was much higher than the national average hinting toward its association with higher incidence of various malignancies in the region and calling for immediate action toward propelling its prevention and control by all stakeholders.
The “Task B problem” and other considerations in developmental functional neuroimaging

Functional neuroimaging provides a remarkable tool to allow us to study cognition across the lifespan and in special populations in a safe way. However, experimenters face a number of methodological issues, and these issues are particularly pertinent when imaging children. This brief article discusses assessing task performance, strategies for dealing with group performance differences, controlling for movement, statistical power, proper atlas registration, and data analysis strategies. In addition, there will be discussion of two other topics that have important implications for interpreting fMRI data: the question of whether functional neuroanatomical differences between adults and children are the consequence of putative developmental neurovascular differences, and the issue of interpreting negative blood oxygenation‐level dependent (BOLD) signal change. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.