Miracle-dz/UniFAR-FTUs huggingface dataset:
An effectiveness study of group psychoeducation for hepatitis C patients in community clinics

Objective A successful psychoeducation program for serious mental illness, PsychoEducation Responsive to Families (PERF), was modified for hepatitis C virus (HCV). An effectiveness study was carried out comparing HCV-PERF with didactic education. Patients and methods A sample of 309 adult HCV patients was recruited from three outpatient settings and randomized (60% HCV-PERF, 40% didactic control). Groups met for 90 min bimonthly for 6 months following separate structured protocols. HCV-PERF sessions included a didactic curriculum developed uniquely for groups by member choice, with group problem-solving and support interactions. Patients were assessed at baseline, after the intervention, and 1 year later. Demographic and HCV-related variables and structured diagnostic interview data were obtained. Results Both groups improved significantly on major depression and alcohol and drug use, quality of life, risk behaviors, and treatment satisfaction, and worsened on disability and perceived HCV-related problems. Intervention groups did not differ on outcomes. Conclusion Even though the active intervention did not achieve a significant improvement relative to the control condition, the observable improvements in both conditions warrant further exploration of the contributions of education and support as potentially important elements of HCV behavioral intervention. Further study is needed to identify elements common to education interventions that may be contributory to the improved outcomes over time.
Current Challenges and Achievements in Maternal Immunization Research

Maternal immunization has the potential to significantly improve maternal and child health worldwide by reducing maternal and infant morbidity and mortality associated with disease caused by pathogens that are particularly relevant in the perinatal period and in early life, and for which no alternative effective preventive strategies exist. Research on all aspects related to vaccines for administration during pregnancy is ongoing with support of multiple stakeholders and global participation. Substantial progress has been made, and the availability of new vaccines licensed exclusively for use in pregnant women to protect their infants has become an achievable goal. This review provides an update of the current challenges and achievements in maternal immunization research, focusing on recent milestones that advance the field and the prospects to make maternal immunization a feasible and accessible strategy to improve global health.
GDF-15 gene expression alterations in human lymphoblastoid cells and peripheral blood lymphocytes following exposure to ionizing radiation

The identification of rapid, sensitive and high-throughput biomarkers is imperative in order to identify individuals harmed by radiation accidents, and accurately evaluate the absorbed doses of radiation. DNA microarrays have previously been used to evaluate the alterations in growth/differentiation factor 15 (GDF15) gene expression in AHH-1 human lymphoblastoid cells, following exposure to γ-rays. The present study aimed to characterize the relationship between the dose of ionizing radiation and the produced effects in GDF-15 gene expression in AHH-1 cells and human peripheral blood lymphocytes (HPBLs). GDF-15 mRNA and protein expression levels following exposure to γ-rays and neutron radiation were assessed by reverse transcription-quantitative polymerase chain reaction and western blot analysis in AHH-1 cells. In addition, alterations in GDF-15 gene expression in HPBLs following ex vivo irradiation were evaluated. The present results demonstrated that GDF-15 mRNA and protein expression levels in AHH-1 cells were significantly upregulated following exposure to γ-ray doses ranging between 1 and 10 Gy, regardless of the dose rate. A total of 48 h following exposure to neutron radiation, a dose-response relationship was identified in AHH-1 cells at γ-ray doses between 0.4 and 1.6 Gy. GDF-15 mRNA levels in HPBLs were significantly upregulated following exposure to γ-ray doses between 1 and 8 Gy, within 4–48 h following irradiation. These results suggested that significant time- and dose-dependent alterations in GDF-15 mRNA and protein expression occur in AHH-1 cells and HPBLs in the early phases following exposure to ionizing radiation. In conclusion, alterations in GDF-15 gene expression may have potential as a biomarker to evaluate radiation exposure.
Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in a Drosophila Model of Friedreich’s Ataxia

Friedreich’s ataxia (FRDA) is the most important recessive ataxia in the Caucasian population. It is caused by a deficit of the mitochondrial protein frataxin. Despite its pivotal effect on biosynthesis of iron-sulfur clusters and mitochondrial energy production, little is known about the influence of frataxin depletion on homeostasis of the cellular mitochondrial network. We have carried out a forward genetic screen to analyze genetic interactions between genes controlling mitochondrial homeostasis and Drosophila frataxin. Our screen has identified silencing of Drosophila mitofusin (Marf) as a suppressor of FRDA phenotypes in glia. Drosophila Marf is known to play crucial roles in mitochondrial fusion, mitochondrial degradation and in the interface between mitochondria and endoplasmic reticulum (ER). Thus, we have analyzed the effects of frataxin knockdown on mitochondrial morphology, mitophagy and ER function in our fly FRDA model using different histological and molecular markers such as tetramethylrhodamine, ethyl ester (TMRE), mitochondria-targeted GFP (mitoGFP), p62, ATG8a, LAMP1, Xbp1 and BiP/GRP78. Furthermore, we have generated the first Drosophila transgenic line containing the mtRosella construct under the UAS control to study the progression of the mitophagy process in vivo. Our results indicated that frataxin-deficiency had a small impact on mitochondrial morphology but enhanced mitochondrial clearance and altered the ER stress response in Drosophila. Remarkably, we demonstrate that downregulation of Marf suppresses ER stress in frataxin-deficient cells and this is sufficient to improve locomotor dysfunction, brain degeneration and lipid dyshomeostasis in our FRDA model. In agreement, chemical reduction of ER stress by means of two different compounds was sufficient to ameliorate the effects of frataxin deficiency in three different fly FRDA models. Altogether, our results strongly suggest that the protection mediated by Marf knockdown in glia is mainly linked to its role in the mitochondrial-ER tethering and not to mitochondrial dynamics or mitochondrial degradation and that ER stress is a novel and pivotal player in the progression and etiology of FRDA. This work might define a new pathological mechanism in FRDA, linking mitochondrial dysfunction due to frataxin deficiency and mitofusin-mediated ER stress, which might be responsible for characteristic cellular features of the disease and also suggests ER stress as a therapeutic target.
The influence of kiln temperature on the performance of handheld moisture meters.

On examine les effets des hautes temperatures sur les performances d'humidimetres portatifs utilises dans les etuves de sechage du bois. Les resultats indiquent que les temperatures maximales de sechage ne necessitent pas de correction des resultats enregistres
On three steps two-grid finite element methods for the 2D-transient Navier-Stokes equations

Abstract In this paper, an error analysis of a three steps two level Galerkin finite element method for the two dimensional transient Navier–Stokes equations is discussed. First of all, the problem is discretized in spatial direction by employing finite element method on a coarse mesh 𝒯H with mesh size H. Then, in step two, the nonlinear system is linearized around the coarse grid solution, say, uH, which is similar to Newton’s type iteration and the resulting linear system is solved on a finer mesh 𝒯h with mesh size h. In step three, a correction is obtained through solving a linear problem on the finer mesh and an updated final solution is derived. Optimal error estimates in L∞(L2)-norm, when h = 𝒪 (H2−δ) and in L∞(H1)-norm, when h = 𝒪(H4−δ) for the velocity and in L∞(L2)-norm, when h = 𝒪(H4−δ) for the pressure are established for arbitrarily small δ > 0. Further, under uniqueness assumption, these estimates are proved to be valid uniformly in time. Then, based on backward Euler method, a completely discrete scheme is analyzed and a priori error estimates are derived. Results obtained in this paper are sharper than those derived earlier by two-grid methods. Finally, the paper is concluded with some numerical experiments.
Systematic Design of a Multiport MIMO Antenna With Bilateral Symmetry Based on Characteristic Mode Analysis

There are various bilaterally symmetric structures in the world. Characteristic mode analysis (CMA) enables to use a conductor with the symmetric structure itself as an antenna. Based on CMA, it is possible to implement a multiport MIMO antenna on the conductor using a mode-decoupling network (MDN). As the number of antennas increases, however, the complexity of the MDN becomes large, making design difficult. In this paper, we propose a simpler systematic design method for a multiport MIMO antenna on an electrically small and bilaterally symmetric conductor. More specifically, the implementation of the MDN depends on the design of the coupling elements that excite characteristic modes, so a design method for its position and shape is proposed. Owing to the well-designed coupling elements, a simple systematic design of the multiport MIMO antenna is suggested. The proposed design method is verified by simulation and measurement of a bug-like 3-port MIMO antenna operating in the 2.4 GHz ISM band, applicable to biomimetic drones. The antenna is realized using an FR-4 substrate with dimensions of 50 mm <inline-formula> <tex-math notation="LaTeX">$\times \,\, 61.5$ </tex-math></inline-formula> mm <inline-formula> <tex-math notation="LaTeX">$\times \,\, 10$ </tex-math></inline-formula> mm (<inline-formula> <tex-math notation="LaTeX">$0.4\lambda _{0} \times 0.49\lambda _{0} \times 0.08\lambda _{0} $ </tex-math></inline-formula> at 2.4 GHz). The measurements demonstrate that these antennas have a low mutual coupling (<−20 dB) and a low envelope correlation coefficient (<0.04).
Animal behaviour and algal camouflage jointly structure predation and selection

Trait variation can structure interactions between individuals, thus shaping selection. Although antipredator strategies are an important component of many aquatic systems, how multiple antipredator traits interact to influence consumption and selection remains contentious. Here, I use a common larval dragonfly (Epitheca canis) and its predator (Anax junius) to test for the joint effects of activity rate and algal camouflage on predation and survival selection. I found that active and poorly camouflaged Epitheca were more likely to be consumed, and thus, survival selection favoured inactive and well‐camouflaged individuals. Notably, camouflage dampened selection on activity rate, likely by reducing attack rates when Epitheca encountered a predator. Correlational selection is therefore conferred by the ecological interaction of traits, rather than by opposing selection acting on linked traits. I suggest that antipredator traits with different adaptive functions can jointly structure patterns of consumption and selection.
Fixed-point Elimination in the Intuitionistic Propositional Calculus

It follows from known results in the literature that least and greatest fixed-points of monotone polynomials on Heyting algebras—that is, the algebraic models of the Intuitionistic Propositional Calculus—always exist, even when these algebras are not complete as lattices. The reason is that these extremal fixed-points are definable by formulas of the IPC. Consequently, the μ-calculus based on intuitionistic logic is trivial, every μ-formula being equivalent to a fixed-point free formula. In the first part of this article, we give an axiomatization of least and greatest fixed-points of formulas, and an algorithm to compute a fixed-point free formula equivalent to a given μ-formula. The axiomatization of the greatest fixed-point is simple. The axiomatization of the least fixed-point is more complex, in particular every monotone formula converges to its least fixed-point by Kleene’s iteration in a finite number of steps, but there is no uniform upper bound on the number of iterations. The axiomatization yields a decision procedure for the μ-calculus based on propositional intuitionistic logic. The second part of the article deals with closure ordinals of monotone polynomials on Heyting algebras and of intuitionistic monotone formulas; these are the least numbers of iterations needed for a polynomial/formula to converge to its least fixed-point. Mirroring the elimination procedure, we show how to compute upper bounds for closure ordinals of arbitrary intuitionistic formulas. For some classes of formulas, we provide tighter upper bounds that, in some cases, we prove exact.
DEVELOPMENT OF MULTIPLE-UNIT MUCOADHESIVE SUSTAIN RELEASE MINI-TABLETS OF BOSENTAN

Objective: To formulate once daily capsule filled with multiple unit mucoadhesive sustain release (SR) mini tablets of bosentan prepared using combination gelucire 43/01 and hydroxypropyl methyl cellulose (HPMCK4M), sodium carboxymethyl cellulose (NaCMC) and chitosan to sustain drug release for 24 h. Methods: The mini tablets were prepared by melt granulation technique using gelucire 43/01 as meltable hydrophobic release retardant. The polymers such as hydroxypropyl methylcellulose (HPMCK4M), sodium carboxymethyl cellulose (NaCMC) and chitosan were added as release modulators and mucoadhesives. The physical mixture of drug and excipient were subjected Fourier transform infrared (FT-IR) and differential scanning calorimetry (DSC) for evaluation of drug-polymer interaction. Mini tablets were evaluated for mucoadhesive strength, in vitro drug release, swelling index and percentage of hydration. The optimized mini tablets of formulation F23 were filled into zero sizes hard gelatin capsule. Results: The release of bosentan from gelucire 43/01 based sustain release mini tablets extended drug release for 24 h with an initial burst release of more than 32 %. Incorporation of NaCMC, HPMCK4M and chitosan into the mini tablets controlled initial burst release with mucoadhesion. Conclusion: Hence mini tablets prepared with a combination of gelucire 43/01 (release retardant) and NaCMC (release modulator and mucoadhesive polymer) filled into zero sizes hard gelatin capsule can be used to formulate once daily formulation of bosentan.
A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations

Drug-induced toxicity is a significant problem in clinical care. A key problem here is a general understanding of the molecular mechanisms accompanying the transition from desired drug effects to adverse events following administration of either therapeutic or toxic doses, in particular within a patient context. Here, a comparative toxicity analysis was performed for fifteen hepatotoxic drugs by evaluating toxic changes reflecting the transition from therapeutic drug responses to toxic reactions at the cellular level. By use of physiologically-based pharmacokinetic modeling, in vitro toxicity data were first contextualized to quantitatively describe time-resolved drug responses within a patient context. Comparatively studying toxic changes across the considered hepatotoxicants allowed the identification of subsets of drugs sharing similar perturbations on key cellular processes, functional classes of genes, and individual genes. The identified subsets of drugs were next analyzed with regard to drug-related characteristics and their physicochemical properties. Toxic changes were finally evaluated to predict both molecular biomarkers and potential drug-drug interactions. The results may facilitate the early diagnosis of adverse drug events in clinical application.
Relevance of CYP3A4*20, UGT1A1*37 and UGT1A1*28 variants in irinotecan‐induced severe toxicity

Severe irinotecan-induced toxicity is associated with UGT1A1 polymorphisms. However, some patients develop side-effects despite harbouring a normal UGT1A1 genotype. As CYP3A4 is also an irinotecan-metabolizing enzyme, our study aimed to elucidate the influence of the CYP3A4*20 loss-of-function allele in the toxicity profile of these patients. Three-hundred and eight metastatic colorectal cancer patients treated with an irinotecan-containing chemotherapy were studied. The presence of CYP3A4*20, UGT1A1*37 and UGT1A1*28 alleles was tested. Associations between these genetic variants and toxicity were evaluated. UGT1A1*28 was significantly associated with severe diarrhoea, neutropenia and asthenia (P = 0.002, P = 0.037 and P = 0.041, respectively). One patient with the UGT1A1*28/*37 genotype presented with grade IV neutropenia and lethal septic shock. One heterozygous UGT1A1 (*1/*28) patient also carried the CYP3A4*20 allele but did not develop toxicity. We confirm that UGT1A1*37 and UGT1A1*28 are associated with severe toxicity and suggest that the CYP3A4*20 allele does not play a role in irinotecan-induced toxicity.
Increased Frequency of Rheumatoid Arthritis and Allergic Rhinitis among Pesticide Sprayers and Associations with Pesticide Use

Objective: The aim of this study was to identify diseases linked with the pesticide sprayer occupation and explore possible associations with exposure history data. Methods: A cross sectional study was conducted among pesticide sprayers (n = 80) and the general population (n = 90) in Thessaly (Greece). Medical history, demographic characteristics and detailed exposure history were recorded by conducting personal interviews. Lifetime exposure indicators were calculated for several pesticide chemical subclasses. Moreover, organophosphate metabolite levels were quantified in urine samples of all participants by using gas chromatography-mass spectrometry (GC-MS). Multinomial analysis was used to determine associations between occupational pesticide exposure and diseases or disorders. Results: In the pesticide sprayers group, significantly higher frequencies for rheumatoid arthritis (RA) and allergic rhinitis were observed compared with the control group (p = 0.002 and p = 0.024 respectively). Within the pesticide sprayers group, high lifetime pesticide exposure was associated with increased risk for reporting RA (OR: 43.07 95% CI: 3.09–600.67) and allergic rhinitis (OR: 9.72 95% CI: 2.31–40.89), compared with low pesticide exposure. Exposure to organophsphate, guanidine and quinone pesticides were associated with RA while organophosphates, pyrethroids and paraquat were associated with allergic rhinitis. Despite the higher levels of certain pesticide metabolites observed among participants with rheumatoid arthritis, the differences were not statistically significant. One metabolite (diethylthiophosphate) was found to be significantly increased in allergic rhinitis cases (p = 0.037). Conclusions: The results from the current study suggest a possible association of occupational pesticide exposure with RA and allergic rhinitis that should be further investigated.
Health Risks and Contamination Levels of Heavy Metals in Dusts from Parks and Squares of an Industrial City in Semi-Arid Area of China

The contamination characteristics and health risk of barium (Ba), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), vanadium (V), zinc (Zn), arsenic (As), mercury (Hg), and cadmium (Cd) in samples of dust gathered from squares and parks of Baotou city, an industrial city situated in a semi-arid location of the northwest China were investigated. The contents of Ba, Co, Cr, Cu, Mn, Ni, V, Pb, and Zn in the collected dust samples were determined using X-ray fluorescence spectrometry, while the contents of As and Hg in the dust were investigated by use of the ICP-MS. Further, cadmium was quantified through the atomic absorption spectrometry. Levels of contamination of heavy metals analyzed in the dust samples were evaluated using the Geo-Accumulation index (Igeo) as well as through a Pollution Load Index (PLI). Their health risks to children and adults were evaluated based on the US EPA model of health risk. The findings portrayed that the mean concentrations of Ba, Co Cr, Cu, Pb, V, Cd, and Hg were elevated as compared with their local soil background values. Mean values of Igeo illustrate the order of Co > Cr> Cd > Hg > Pb > Cu > Ba > V > Ni > Mn > Zn > As. It was evident that dusts from the parks and squares were “unpolluted” to “moderately polluted”. Assessment of health risk depicts that ingestion is the foremost route of exposure in regard to the heavy metals, then the dermal adsorption follows. Hg exposure from dust might also set impending health threats to children. Besides, the cancer risks of Co, Cr, Ni, Cd, and As are considered to be within the presently tolerable range.
Global ocean storage of anthropogenic carbon

The global ocean is a significant sink for anthropogenic carbon (C-ant), absorbing roughly a third of human CO2 emitted over the industrial period. Robust estimates of the magnitude and variability of the storage and distribution of C-ant in the ocean are therefore important for understanding the human impact on climate. In this synthesis we review observational and model-based estimates of the storage and transport of C-ant in the ocean. We pay particular attention to the uncertainties and potential biases inherent in different inference schemes. On a global scale, three data-based estimates of the distribution and inventory of C-ant are now available. While the inventories are found to agree within their uncertainty, there are considerable differences in the spatial distribution. We also present a review of the progress made in the application of inverse and data assimilation techniques which combine ocean interior estimates of C-ant with numerical ocean circulation models. Such methods are especially useful for estimating the air-sea flux and interior transport of C-ant, quantities that are otherwise difficult to observe directly. However, the results are found to be highly dependent on modeled circulation, with the spread due to different ocean models at least as large as that from the different observational methods used to estimate C-ant. Our review also highlights the importance of repeat measurements of hydro-graphic and biogeochemical parameters to estimate the storage of C-ant on decadal timescales in the presence of the variability in circulation that is neglected by other approaches. Data-based C-ant estimates provide important constraints on forward ocean models, which exhibit both broad similarities and regional errors relative to the observational fields. A compilation of inventories of C-ant gives us a "best" estimate of the global ocean inventory of anthropogenic carbon in 2010 of 155 +/- 31 PgC (+/- 20% uncertainty). This estimate includes a broad range of values, suggesting that a combination of approaches is necessary in order to achieve a robust quantification of the ocean sink of anthropogenic CO2.