Miracle-dz/UniFAR-FTUs huggingface dataset:
Do patients with long-term side effects of cancer treatment benefit from general practitioner support? A literature review

Background Alongside specialist cancer clinics, general practitioners have an important role in cancer patients’ follow-up care, yet no literature summarises the nature, extent and impact of their involvement. This paper addresses this issue through a review of the literature. Methods Studies were sourced from six academic databases - AustHealth (n = 202), CINAHL (n = 500), the Cochrane Library (reviews and trials; n = 200), Embase (n = 368), PHCRIS (n = 132) and PubMed/Medline (n = 410). Studies that focused on interventions designed for patients receiving follow-up care and reported cancer care provided by a general practitioner delivered alongside specialist care were reviewed. Results A total of 19 papers were identified as relevant for this review (3 randomised control trials; 4 cross-sectional, 5 cohort and 3 qualitative studies, and 3 systematic reviews). The reviewed studies indicated that providing general practitioner-led supportive interventions for post-treatment care of cancer patients is feasible and acceptable to patients. General practitioner involvement resulted in improved physical and psychosocial well-being of patients and continuity of care, especially for patients with concomitant health conditions. Conclusion Involving general practitioners in post-treatment cancer care is beneficial to patients. However, proactive initiatives that encourage and facilitate patients to consult their general practitioner about their needs or symptoms of recurrence should be considered.
Text Mining the History of Medicine

Historical text archives constitute a rich and diverse source of information, which is becoming increasingly readily accessible, due to large-scale digitisation efforts. However, it can be difficult for researchers to explore and search such large volumes of data in an efficient manner. Text mining (TM) methods can help, through their ability to recognise various types of semantic information automatically, e.g., instances of concepts (places, medical conditions, drugs, etc.), synonyms/variant forms of concepts, and relationships holding between concepts (which drugs are used to treat which medical conditions, etc.). TM analysis allows search systems to incorporate functionality such as automatic suggestions of synonyms of user-entered query terms, exploration of different concepts mentioned within search results or isolation of documents in which concepts are related in specific ways. However, applying TM methods to historical text can be challenging, according to differences and evolutions in vocabulary, terminology, language structure and style, compared to more modern text. In this article, we present our efforts to overcome the various challenges faced in the semantic analysis of published historical medical text dating back to the mid 19th century. Firstly, we used evidence from diverse historical medical documents from different periods to develop new resources that provide accounts of the multiple, evolving ways in which concepts, their variants and relationships amongst them may be expressed. These resources were employed to support the development of a modular processing pipeline of TM tools for the robust detection of semantic information in historical medical documents with varying characteristics. We applied the pipeline to two large-scale medical document archives covering wide temporal ranges as the basis for the development of a publicly accessible semantically-oriented search system. The novel resources are available for research purposes, while the processing pipeline and its modules may be used and configured within the Argo TM platform.
The microRNAs in an Ancient Protist Repress the Variant-Specific Surface Protein Expression by Targeting the Entire Coding Sequence

microRNAs (miRNA) have been detected in the deeply branched protist, Giardia lamblia, and shown to repress expression of the family of variant-specific surface proteins (VSPs), only one of which is expressed in Giardia trophozoite at a given time. Three next-generation sequencing libraries of Giardia Argonaute-associated small RNAs were constructed and analyzed. Analysis of the libraries identified a total of 99 new putative miRNAs with a size primarily in the 26 nt range similar to the size previously predicted by the Giardia Dicer crystal structure and identified by our own studies. Bioinformatic analysis identified multiple putative miRNA target sites in the mRNAs of all 73 VSPs. The effect of miRNA target sites within a defined 3′-region were tested on two vsp mRNAs. All the miRNAs showed partial repression of the corresponding vsp expression and were additive when the targeting sites were separately located. But the combined repression still falls short of 100%. Two other relatively short vsp mRNAs with 15 and 11 putative miRNA target sites identified throughout their ORFs were tested with their corresponding miRNAs. The results indicate that; (1) near 100% repression of vsp mRNA expression can be achieved through the combined action of multiple miRNAs on target sites located throughout the ORF; (2) the miRNA machinery could be instrumental in repressing the expression of vsp genes in Giardia; (3) this is the first time that all the miRNA target sites in the entire ORF of a mRNA have been tested and shown to be functional.
Identifying the most Influential Groups in Determining Singapore's Fertility

Abstract In recent years, various pro-natalist policies have been adopted in Singapore and other high-income Asian countries with low fertility, aiming at raising fertility rates. Previous studies were mainly focused on the impact or outcome of the policies. This paper, however, aims to identify the most influential groups in determining Singapore's total fertility rate (TFR) and evaluate the targeting of pro-natalist measures adopted by the government. We first reveal the changing age-parity-and-marital-status composition of women at childbearing age, and further conduct an elasticity analysis to assess the roles of different subgroups of women in changing the TFR. Our results show that compared to other groups, the 20–29-year-old single women and the married childless women aged 30–34 (‘married’ throughout this paper includes women who are or have been married) are more influential in determining the TFR and should be the potential pro-natalist target groups. However, Singapore's pro-natalist policies are more in favour of third and higher-order births. Such mismatch indicates that, if more efforts are devoted to facilitating marriage and first births in these potential groups, the TFR may be increased effectively. In order to achieve a long-term and significant fertility reversal, it calls for a long-term and integrated policy package.
Sensory Neuropathy Attributable to Loss of Bcl-w

Small fiber sensory neuropathy is a common disorder in which progressive degeneration of small-diameter nociceptors causes decreased sensitivity to thermal stimuli and painful sensations in the extremities. In the majority of patients, the cause of small fiber sensory neuropathy is unknown, and treatment options are limited. Here, we show that Bcl-w (Bcl-2l2) is required for the viability of small fiber nociceptive sensory neurons. Bcl-w−/− mice demonstrate an adult-onset progressive decline in thermosensation and a decrease in nociceptor innervation of the epidermis. This denervation occurs without cell body loss, indicating that lack of Bcl-w results in a primary axonopathy. Consistent with this phenotype, we show that Bcl-w, in contrast to the closely related Bcl-2 and Bcl-xL, is enriched in axons of sensory neurons and that Bcl-w prevents the dying back of axons. Bcl-w−/− sensory neurons exhibit mitochondrial abnormalities, including alterations in axonal mitochondrial size, axonal mitochondrial membrane potential, and cellular ATP levels. Collectively, these data establish bcl-w−/− mice as an animal model of small fiber sensory neuropathy and provide new insight regarding the role of Bcl-w and of mitochondria in preventing axonal degeneration.
Sleep-related hypermotor epilepsy

Objective: To assess the long-term outcome of sleep-related hypermotor epilepsy (SHE). Methods: We retrospectively reconstructed a representative cohort of patients diagnosed with SHE according to international diagnostic criteria, sleep-related seizures ≥75% and follow-up ≥5 years. Terminal remission (TR) was defined as a period of ≥5 consecutive years of seizure freedom at the last follow-up. We used Kaplan-Meier estimates to calculate the cumulative time-dependent probability of TR and to generate survival curves. Univariate and multivariate Cox regression analyses were performed. Results: We included 139 patients with a 16-year median follow-up (2,414 person-years). The mean age at onset was 13 ± 10 years. SHE was sporadic in 86% of cases and familial in 14%; 16% of patients had underlying brain abnormalities. Forty-five percent of patients had at least 1 seizure in wakefulness lifetime and 55% had seizures only in sleep (typical SHE). At the last assessment, 31 patients achieved TR (TR group, 22.3%), while 108 (NTR group, 77.7%) still had seizures or had been in remission for <5 years. The cumulative TR rate was 20.4%, 23.5%, and 28.4% by 10, 20, and 30 years from inclusion. At univariate analysis, any underlying brain disorder (any combination of intellectual disability, perinatal insult, pathologic neurologic examination, and brain structural abnormalities) and seizures in wakefulness were more frequent among the NTR group (p = 0.028; p = 0.043). Absence of any underlying brain disorder (hazard ratio 4.21, 95% confidence interval 1.26–14.05, p = 0.020) and typical SHE (hazard ratio 2.76, 95% confidence interval 1.31–5.85, p = 0.008) were associated with TR. Conclusions: Our data show a poor prognosis of SHE after a long-term follow-up. Its outcome is primarily a function of the underlying etiology.
On the Synthesis of Sequential Reversible Circuit

Reversible circuits for SR flip flop, JK flip flop, D flip flop, T flip flop, Master Slave D flip flop and Master Slave JK flip flop have been provided with three different logical approaches. All the circuits have been optimized with the help of existing local optimization algorithms (e.g. template matching, moving rule and deletion rule) and the optimized sequential circuits have been compared with the earlier proposals for the same. It has been shown that the present proposals have lower gate complexities and lower number of garbage bits compared to the earlier proposals. It has also been shown that the advantage in gate count obtained in some of the earlier proposals by introduction of New gates is an \textcolor{black}{artifact} and if it is allowed then every circuit block (unless there is a measurement) can be reduced to a single gate. Further, it is shown that a reversible flip flop can be constructed even without a feedback. In this context, some important conceptual issues related to the designing and optimization of sequential reversible circuits have also been addressed.
Approximating Solution for Systems of Strongly Accretive Operator Equations on Weakly Continuous Duality Maps

This paper introduce a iteration scheme for approximation of strongly accretive operator equations in reflexive Banach space with weakly continuous duality mapping. Our result improve the results of Y. Xu [Ishikawa and Mann Iterative Processes with Errors for Nonlinear Strongly Accretive Operator Equations, J. Math. Anal Appl. 224(1998) 91-101] and I. Inchan and S. Plubtieng [Approximating solutions for the systems of strongly accretive operator equations, Com. Math. Appl. 53(2007) 1317-1324] and many author. Mathematics Subject Classification: 47H10, 47H09, 46B20
PHOX2B-Mediated Regulation of ALK Expression: In Vitro Identification of a Functional Relationship between Two Genes Involved in Neuroblastoma

Background Neuroblastoma (NB) is a severe pediatric tumor originating from neural crest derivatives and accounting for 15% of childhood cancer mortality. The heterogeneous and complex genetic etiology has been confirmed with the identification of mutations in two genes, encoding for the receptor tyrosine kinase Anaplastic Lymphoma Kinase (ALK) and the transcription factor Paired-like Homeobox 2B (PHOX2B), in a limited proportion of NB patients. Interestingly, these two genes are overexpressed in the great majority of primary NB samples and cell lines. These observations led us to test the hypothesis of a regulatory or functional relationship between ALK and PHOX2B underlying NB pathogenesis. Methodology/Principal Findings Following this possibility, we first confirmed a striking correlation between the transcription levels of ALK, PHOX2B and its direct target PHOX2A in a panel of NB cell lines. Then, we manipulated their expression in NB cell lines by siRNA-mediated knock-down and forced over-expression of each gene under analysis. Surprisingly, PHOX2B- and PHOX2A-directed siRNAs efficiently downregulated each other as well as ALK gene and, consistently, the enhanced expression of PHOX2B in NB cells yielded an increment of ALK protein. We finally demonstrated that PHOX2B drives ALK gene transcription by directly binding its promoter, which therefore represents a novel PHOX2B target. Conclusions/Significance These findings provide a compelling explanation of the concurrent involvement of these two genes in NB pathogenesis and are going to foster a better understanding of molecular interactions at the base of the disease. Moreover, this work opens new perspectives for NBs refractory to conventional therapies that may benefit from the design of novel therapeutic RNAi-based approaches for multiple gene targets.
Molecular gas in the central regions of the latest-type spiral galaxies

Using the IRAM 30 m telescope, we have surveyed an unbiased sample of 47 nearby spiral galaxies of very late (Scd-Sm) Hubble-type for emission in the 12 CO(1−0) and (2−1) lines. The sensitivity of our data (a few mK) allows detection of about 60% of our sample in at least one of the CO lines. The median detected H2 mass is 1.4 × 10 7 Mwithin the central few kpc, assuming a standard conversion factor. We use the measured line intensities to complement existing studies of the molecular gas content of spiral galaxies as a function of Hubble-type and to significantly improve the statistical significance of such studies at the late end of the spiral sequence. We find that the latest-type spirals closely follow the correlation between molecular gas content and galaxy luminosity established for earlier Hubble types. The molecular gas in late-type galaxies seems to be less centrally concentrated than in earlier types. We use Hubble Space Telescope optical images to correlate the molecular gas mass to the properties of the central galaxy disk and the compact star cluster that occupies the nucleus of most late-type spirals. There is no clear correlation between the luminosity of the nuclear star cluster and the molecular gas mass, although the CO detection rate is highest for the brightest clusters. It appears that the central surface brightness of the stellar disk is an important parameter for the amount of molecular gas at the galaxy center. Whether stellar bars play a critical role for the gas dynamics remains unclear, in part because of uncertainties in the morphological classifications of our sample.
Automated Measurement of Vowel Formants in the Buckeye Corpus

In recent years, corpus phonetics has become a rapidly expanding field. However, the lack of appropriate tools for automatic acoustic analysis hinders further development of the field. In this paper, we present a methodological study on the automatic extraction of vowel formants using both robust linear predictive coding (RLPC; Lee, 1988) and dynamic formant tracking (Talkin, 1987). Acoustic data were taken from the Buckeye corpus of English conversations. We varied two aspects of the analysis - preemphasis and LPC order - to optimize formant tracking results by speaker and vowel. We also show, based on the optimal results, the distribution of ten English vowels in the F1/F2 space in conversational speech.
Tests of general relativity in the solar system

Tests of gravity performed in the solar system show a good agreement with general relativity. The latter is however challenged by observations at larger, galactic and cosmic, scales which are presently cured by introducing "dark matter" or "dark energy". A few measurements in the solar system, particularly the so-called "Pioneer anomaly", might also be pointing at a modification of gravity law at ranges of the order of the size of the solar system. The present lecture notes discuss the current status of tests of general relativity in the solar system. They describe metric extensions of general relativity which have the capability to preserve compatibility with existing gravity tests while opening free space for new phenomena. They present arguments for new mission designs and new space technologies as well as for having a new look on data of existing or future experiments.
Processive translocation mechanism of the human Bloom’s syndrome helicase along single-stranded DNA

BLM, one of the human RecQ helicases, plays a fundamental role in homologous recombination-based error-free DNA repair pathways, which require its translocation and DNA unwinding activities. Although translocation is essential in vivo during DNA repair processes and it provides a framework for more complex activities of helicases, including strand separation and nucleoprotein displacement, its mechanism has not been resolved for any human DNA helicase. Here, we present a quantitative model for the translocation of a monomeric form of BLM along ssDNA. We show that BLM performs translocation at a low adenosine triphosphate (ATP) coupling ratio (1 ATP consumed/1 nucleotide traveled) and moderate processivity (with a mean number of 50 nucleotides traveled in a single run). We also show that the rate-limiting step of the translocation cycle is a transition between two ADP-bound enzyme states. Via opening of the helicase core, this structural change may drive the stepping of BLM along the DNA track by a directed inchworm mechanism. The data also support the conclusion that BLM performs double-stranded DNA unwinding by fully active duplex destabilization.
A submillimetre galaxy at z = 4.76 in the LABOCA survey of the Extended Chandra Deep Field-South

We report on the identification of the highest redshift submillimetre-selected source currently known LESS J033229.4−275619. This source was detected in the Large Apex Bolometer Camera (LABOCA) Extended Chandra Deep Field-South (ECDF-S) Submillimetre Survey (LESS), a sensitive 870-μm survey (σ_(870 μm)∼ 1.2 mJy) of the full 30 × 30 arcmin_2 ECDF-S with the LABOCA on the Atacama Pathfinder Experiment telescope. The submillimetre emission is identified with a radio counterpart for which optical spectroscopy provides a redshift of z= 4.76 . We show that the bolometric emission is dominated by a starburst with a star formation rate of ∼1000 M_⊙ yr^(−1), although we also identify a moderate luminosity active galactic nucleus (AGN) in this galaxy. Thus it has characteristics similar to those of z∼ 2 submillimetre galaxies (SMGs), with a mix of starburst and obscured AGN signatures. This demonstrates that ultraluminous starburst activity is not just restricted to the hosts of the most luminous (and hence rare) quasi-stellar objects at z∼ 5 , but was also occurring in less extreme galaxies at a time when the Universe was less than 10 per cent of its current age. Assuming that we are seeing the major phase of star formation in this galaxy, then we demonstrate that it would be identified as a luminous distant red galaxy at z∼ 3 and that the current estimate of the space density of z > 4 SMGs is only sufficient to produce ≳10 per cent of the luminous red galaxy population at these early times. However, this leaves open the possibility that some of these galaxies formed through less intense, but more extended star formation events. If the progenitors of all of the luminous red galaxies at z∼ 3 go through an ultraluminous starburst at z≳ 4 then the required volume density of z > 4 SMGs will exceed that predicted by current galaxy formation models by more than an order of magnitude.
The Impact of Global English on Motivation to Learn Other Languages: Toward an Ideal Multilingual Self

In 2006, Graddol predicted that numbers of 'English as a foreign language' learners would begin to decline through the second decade of this century, as global English achieves basic skill status for children entering education in more societies across the world. As he further noted, having skills in additional languages may thus offer a competitive edge in a global job market where English skills have become commonplace, and where monolingual and even bilingual English speakers may lose out to multilingual competitors. As yet, however, the extent to which the spread of global English may motivate individuals to diversify their language skills beyond English seems limited. Rather, both empirical evidence and commonly held perceptions would seem to endorse the view that global English tends to impact negatively on motivation to learn other languages, despite the growing linguistic and cultural diversity of today's societies. This article critically analyses this impact on motivation from two perspectives. First, from a macro-sociological perspective, it explores the tensions among language globalization, multiculturalism, and multilingualism in today's changing social world and examines the mixed messages communicated for language education in general and for language learners in particular. In so doing, it considers the socially distributed nature of motivation at the level of societal multilingualism and educational policy and practice, and the impact of the social on the individual. Second, from a theoretical perspective, the article considers whether the impact of global English on motivation to learn other languages might be more positively construed by shifting away from SLA frames of reference (concerned with progression toward proficiency in a particular language) in favour of a 'linguistic multi-competence' framework, defined by Cook (2016) as the overall system of a mind or community that uses more than one language. As the article concludes, an important pedagogical implication would be a focus on multilingual (rather than L2) speakers as the normative model of communication and instruction, and the associated promotion of ideal multilingual selves. [ABSTRACT FROM AUTHOR]
Robust Stabilization of the Distributed Parameter System With Time Delay via Fuzzy Control

In this paper, stabilization of the distributed parameter system (DPS) with time delay is studied using Galerkin's method and fuzzy control. With the help of Galerkin's method, the dynamics of DPS with time delay can be first converted into a group of low-order functional ordinary differential equations, which will be used for design of the robust fuzzy controller. The fuzzy controller designed can guarantee exponential stability of the closed-loop DPS. Some sufficient conditions are derived for the stabilization together with the linear matrix inequality design approach. The effectiveness of the proposed control design methodology is demonstrated in numerical simulations.