Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of the political context on discourse characteristics in Jewish–Arab encounters in Israel: between peace talks and violent events

Research in the field of intergroup relations has developed considerably over the last two decades, influenced by events and by the historical zeitgeist. We suggest applying an interactional way of dealing with intergroup encounters, which emphasizes the situational macro‐context (political, historical and social) in which the contact takes place. Employing this approach, the impact of the social‐political context on the characteristics of two encounters in which Jewish and Arab Israeli students met to deal with the Israeli–Arab political conflict was examined. The workshops took place within two completely different political contexts. The first workshop was at the time of peace talks, following the Oslo Accords (1996–1997), the second during the al‐Aksa Intifada (2001–2002). The discussions were recorded and fully transcribed. The two workshops were compared using a typology for classification of the developmental process of discourse between groups. The analysis revealed that during the peace talks ‘ethnocentric discourse’ was the dominant speech category, characterized by two monologues that do not meet. In the second workshop dialogic categories characterized by sharing of feelings, listening to the ‘other’ and making an effort to understand how reality looks from his/her perspective were salient. The research findings are discussed with regard to the paradoxical impact of the political–social context on discourse in small groups. The findings give a new understanding of the role of small intergroup meetings against the background of violent reality in an intractable conflict.
New York City English and second generation Chinese Americans

Although Chinese Americans set up Chinese heritage language schools as early as 1848 to preserve the heritage language and to promote a sense of ethnic identity among their American-born children (Chao, 1997), there is strong evidence that language shift to English is taking place rather rapidly within the Chinese communities across the U.S. Data from the 2006 ACS show that while only 34.1 percent of first generation (i.e. foreign-born) Chinese Americans reported speaking ‘English very well’, the percentages rise dramatically for those who are American-born (i.e. second generation and beyond) or born overseas but arrived in the U.S. before the age of 16 (i.e. the 1.5 generation). 70.4 percent of the 1.5 generation and 93.8 percent of the American-born Chinese Americans reported speaking ‘English very well’. Additionally, only about 27.6 percent of the ABCs were estimated to speak their heritage language at home. Taken together, these estimates suggest that the rate of shift from Chinese to English is accelerating. Jia (2008) finds that even for first generation Chinese Americans, their Chinese language skills continue to decline with increasing English immersion. Rapid language shift to English means that many ABCs speak English as one of their native languages, if not the only one. This raises interesting sociolinguistic questions concerning the characteristics of the English spoken by ABCs and how ABCs utilize varieties of English to construct and negotiate differences with respect to each other and vis-à-vis the larger social structure.
Clinical Role of Subtraction Ictal SPECT Coregistered to MR Imaging and 18F-FDG PET in Pediatric Epilepsy

A precise assessment of the drug-resistant epileptic pediatric population for surgical candidacy is often challenging, and to date there are no evidence-based guidelines for presurgical identification of the epileptogenic zone. To evaluate the usefulness of radionuclide imaging techniques for presurgical evaluation of epileptic pediatric patients, we compared the results of video-electroencephalography (EEG), brain MR imaging, interictal SPECT, ictal SPECT, subtraction ictal SPECT coregistered to MR imaging (SISCOM), and interictal PET with 18F-FDG. Methods: Fifty-four children with drug-resistant epilepsy who had undergone video-EEG monitoring, brain MR imaging, interictal and ictal brain perfusion SPECT, SISCOM, and 18F-FDG PET were included in this study. All abnormal findings revealed by these neuroimaging techniques were compared with the presumed location of the epileptogenic zone (PEZ) as determined by video-EEG and clinical data. The proportion of localizing studies for each technique was statistically compared. In the 18 patients who underwent resective brain surgery, neuroimaging results were compared with histopathology results and surgical outcome. Results: SISCOM and 18F-FDG PET concordance with the PEZ was significantly higher than MR imaging (P < 0.05). MR imaging showed localizing results in 21 of 54 cases (39%), SISCOM in 36 of 54 cases (67%), and 18F-FDG PET in 31 of 54 cases (57%). If we consider SISCOM and 18F-FDG PET results together, nuclear medicine imaging techniques showed coinciding video-EEG results in 76% of patients (41/54). In those cases in which MR imaging failed to identify any epileptogenic lesion (61% [33/54]), SISCOM or 18F-FDG PET findings matched PEZ in 67% (22/33) of cases. Conclusion: SISCOM and 18F-FDG PET provide complementary presurgical information that matched video-EEG results and clinical data in three fourths of our sample. SISCOM was particularly useful in those cases in which MR imaging findings were abnormal but no epileptogenic lesion was identified. Radionuclide imaging techniques are both useful and reliable, extending the possibility of surgical treatment to patients who may have been discouraged without a nuclear medicine approach.
Systematic review of percutaneous adhesiolysis and management of chronic low back pain in post lumbar surgery syndrome.

BACKGROUND Post lumbar surgery syndrome or failed back surgery syndrome with persistent pain continues to increase over the years. The speculated causes of post lumbar laminectomy syndrome include acquired stenosis, epidural fibrosis, arachnoiditis, radiculopathy, and recurrent disc herniation. Epidural fibrosis may account for as much as 20% to 36% of all cases of failed back surgery syndrome. Percutaneous epidural adhesiolysis has been employed in interventional pain management in the treatment of chronic, refractory low back and lower extremity pain after back surgery. STUDY DESIGN A systematic review of randomized trials and observational studies. OBJECTIVE To evaluate the effectiveness of percutaneous adhesiolysis in managing chronic low back and lower extremity pain due to post lumbar surgery syndrome. METHODS A comprehensive literature search was conducted utilizing electronic databases, as well as systematic reviews and cross references from 1966 through December 2008. The quality of individual articles used in this analysis was assessed by modified Cochrane review criteria for randomized trials and the Agency for Healthcare Research and Quality (AHRQ) criteria for assessment of observational studies. Clinical relevance was evaluated using 5 questions according to the criteria recommended by the Cochrane Review Back Group. Analysis was conducted using 5 levels of evidence, ranging from Level I to III, with 3 subcategories in Level II. OUTCOME PARAMETERS The primary outcome measure was pain relief (short-term relief of at least 6 months and long-term relief of more than 6 months). Secondary outcome measures were improvement in functional status, psychological status, return to work, and change in opioid intake. RESULTS Of the 13 studies considered for inclusion, 3 randomized trials and 4 observational studies met the inclusion criteria for methodologic quality assessment and evidence synthesis based on methodologic quality scores of 50 or more. Evidence of percutaneous adhesiolysis in the management of chronic low back pain in post-lumbar surgery syndrome is Level I to Level II-1, with evidence derived from 3 randomized trials. LIMITATIONS There is a paucity of efficacy and pragmatic trials. No trials have been published after 2006. CONCLUSION The indicated level of evidence for percutaneous adhesiolysis is Level I or II-1 based on the US Preventative Services Task Force (USPSTF) criteria.
The Combination of Multiple Receptor Tyrosine Kinase Inhibitor and Mammalian Target of Rapamycin Inhibitor Overcomes Erlotinib Resistance in Lung Cancer Cell Lines through c-Met Inhibition

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) show antitumor activity in a subset of non–small cell lung cancer (NSCLC) patients. However, the initial tumor response is followed by recurrence. Several studies have suggested the importance of other receptor tyrosine kinases (RTK) and downstream kinases as potential targets in the treatment of NSCLC. We used the multiple-RTK inhibitor AEE788, which inhibits EGFR, vascular endothelial growth factor receptor, and human epidermal growth factor receptor 2, with and without the downstream kinase inhibitor RAD001 (an inhibitor of mammalian target of rapamycin). AEE788 inhibited cell growth more effectively than did erlotinib in three NSCLC cell lines examined (A549, H1650, and H1975). However, in the EGFR-TKI–resistant cell line H1975 harboring T790M resistance mutation, cell growth inhibition by AEE788 was only mild, and the phosphorylation of its leading targets such as EGFR and vascular endothelial growth factor receptor 2 was not inhibited. In H1975, AEE788 induced significantly greater cell growth inhibition when combined with RAD001 than when used alone. This cooperative effect was not seen with the combination of erlotinib and RAD001. We found that c-Met was highly phosphorylated in this cell line, and the phosphorylated c-Met was inhibited effectively by AEE788. Using a phospho-RTK array, the phosphorylation of c-Met and insulin-like growth factor-I receptor was inhibited by AEE788. These results suggest that upstream RTK inhibitor overcomes the acquired resistance to EGFR-TKI when combined with downstream kinase inhibitor. Thus, the combined inhibition of upstream and downstream RTKs is a promising strategy for the treatment of NSCLC. Mol Cancer Res; 8(8); 1142–51. ©2010 AACR.
Researching female professors: the difficulties of representation, positionality and power in feminist research

This article draws on findings from my doctoral research to exemplify some of the difficulties I encountered when interviewing 20 female professors1 and subsequently writing about their life histories. In this article, I discuss how I addressed the issues of representing and positioning my participants, and I reflect on the power dynamics present in the research process. The article contends that by drawing on Bourdieu and Wacquant's [An Invitation to Reflexive Sociology. Chicago, IL: University of Chicago Press] understanding of reflexivity and feminist interpretations of their work including McNay [“Gender, Habitus and the Field: Pierre Bourdieu and the Limits of Reflexivity. ” Theory Culture Society 16: 95] and Adkins [“Reflexivity Freedom or Habit of Gender? ” Theory Culture Society 20: 21], valuable research can be produced, despite the difficulties. A related aim of this paper is to reflect back after four years in an academic post on my position as a novice researcher, and some of the associated issues facing doctoral students, particularly the problems with researching upwards [Walford, G. 2011. “Researching the Powerful. British Educational Research Association On-line Resource. ” Accessed March 17, 2014. www.bera. ac.uk/system/files/Researching%20the%20Powerful.pdfWalford 2011].
Developmental profiles in tick water balance with a focus on the new Rocky Mountain spotted fever vector, Rhipicephalus sanguineus

Abstract Recent reports indicate that the common brown dog tick, or kennel tick, Rhipicephalus sanguineus (Latreille) (Acari: Ixodidae) is a competent vector of Rocky Mountain spotted fever in the U.S.A. This tick is of concern to public health because of its high frequency of contact, as it has a unique ability to thrive within human homes. To assess the moisture requirements necessary for survival, water balance characteristics were determined for each developmental stage, from egg to adult. This is the first time that water relations in ticks have been assessed throughout the complete lifecycle. Notably, R. sanguineus is differentially adapted for life in a dry environment, as characterized by a suppressed water loss rate distinctive for each stage that distinguishes it from other ticks. Analysis of its dehydration tolerance limit and percentage body water content provides no evidence to suggest that the various stages of this tick can function more effectively containing less water, indicating that this species is modified for water conservation, not desiccation hardiness. All stages, eggs excepted, absorb water vapour from the air and can drink free water to replenish water stores. Developmentally, a shift in water balance strategies occurs in the transition from the larva, where the emphasis is on water gain (water vapour absorption from drier air), to the adult, where the emphasis is on water retention (low water loss rate). These results on the xerophilic‐nature of R. sanguineus identify overhydration as the primary water stress, indicating that this tick is less dependent upon a moisture‐rich habitat for survival, which matches its preference for a dry environment. We suggest that the controlled, host‐confined conditions of homes and kennels have played a key role in promoting the ubiquitous distribution of R. sanguineus by creating isolated arid environments that enable this tick to establish within regions that are unfavourable for maintaining water balance.
Indoor Place Recognition System for Localization of Mobile Robots

In this paper we present a method for robots to do visual place recognition and categorization. The robot learns from experience and then recognizes previously observed places in known environments and categorizes previously unseen places in new environments. This system has been practically tested with a novel dataset developed by us to validate the theoretical results of the proposed system. A Histogram of Oriented Uniform Patters (HOUP) descriptor has been used to represent an image and then appropriate classifiers have been used to perform the classification tasks. It is shown that our method not only performs well on our dataset but also on existing datasets. A major contribution of this work is that this is the first real time implementation of a HOUP descriptor on two mobile robot platforms. Finally we built a novel dataset of seventeen indoor places for doing place recognition and validated our method in real time on this dataset.
Musculoskeletal simulation can help explain selective muscle degeneration in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a genetic disease that occurs due to the deficiency of the dystrophin protein. Although dystrophin is deficient in all muscles, it is unclear why degeneration progresses differently across muscles in DMD. We hypothesized that each muscle undergoes a different degree of eccentric contraction during gait, which could contribute to the selective degeneration in lower limb muscle, as indicated by various amounts of fatty infiltration. By comparing eccentric contractions quantified from a previous multibody dynamic musculoskeletal gait simulation and fat fractions quantified in a recent imaging study, our preliminary analyses show a strong correlation between eccentric contractions during gait and lower limb muscle fat fractions, supporting our hypothesis. This knowledge is critical for developing safe exercise regimens for the DMD population. This study also provides supportive evidence for using multiscale modeling and simulation of the musculoskeletal system in future DMD research. Muscle Nerve 52: 174–182, 2015
High‐resolution X‐ray microtomography for three‐dimensional imaging of cardiac progenitor cell homing in infarcted rat hearts

The recent introduction of stem cells in cardiology provides new tools in understanding the regenerative processes of the normal and pathological heart and has opened a search for new therapeutic strategies. Recent published reports have contributed to identifying possible cellular therapy approaches to generate new myocardium, involving transcoronary and intramyocardial injection of progenitor cells. However, one of the limiting factors in the overall interpretation of clinical results obtained by cell therapy is represented by the lack of three‐dimensional (3D) high‐resolution methods for the visualization of the injected cells and their fate within the myocardium. This work shows that X‐ray computed microtomography may offer the unique possibility of detecting, with high definition and resolution and in ex vivo conditions, the 3D spatial distribution of rat cardiac progenitor cells, labelled with iron oxide nanoparticles, inside the infarcted rat heart early after injection. The obtained 3D images represent a very innovative progress as compared to experimental two‐dimensional (2D) histological analysis, which requires time‐consuming energies for image reconstruction in order to provide the overall distribution of rat clonogenic cells within the heart. Through microtomography, we were able to observe in 3D the presence of these cells within damaged cardiac tissue, with important structural details that are difficult to visualize by conventional bidimensional imaging techniques. This new 3D‐imaging approach appears to be an important way to investigate the cellular events involved in cardiac regeneration and represents a promising tool for future clinical applications. Copyright © 2011 John Wiley & Sons, Ltd.
TiTlE Maternal teaching behaviour and preverbal development of children with Down syndrome and typically developing children

The objective of the current study was to identify and compare maternal teaching behaviours in interactions with infants with Down syndrome and typically developing infants, in relation to their pre-verbal development. Teaching behaviours defined based on a mediational theory perspective, were videotaped and examined in interactions with 38 infants with Down syndrome and 38 typically developing infants, in relation to their Pre-verbal Communication development from 7-9 to 20-22 months. The gap in the development of Pre-verbal Communication between the two groups in favour of typically developing children became clearly apparent at 14-16 months and coincided with a gap in frequency of maternal teaching behaviours provided to each group. Mothers of children with Down syndrome used more ‘isolated’ Focusing which was negatively related to measures of Pre-verbal Communication and less Affecting and Expanding which were positively related to Pre-verbal Communication as compared with mothers of typically developing children. For children with Down syndrome, Regulation of behaviour and Affecting observed at 14-16 months were the best predictors of pre-verbal development at 20-22 months. For children with Down syndrome and typically developing children, sequences of parental behaviour including Focusing accompanied by Affecting or Expanding, observed at 14-16 months, predicted pre-verbal development and Bayley scores, at 20-22 months, whereas ‘isolated’ Focusing behaviour was a negative predictor of the above. These findings suggest the need to direct teaching behaviour in meaningful sequences rather than in isolation.
Self- and Peer-Reported Personality: Agreement, Trait Ratability, and the “Self-Based Heuristic

Abstract Agreement between self- and peer-reported personality was investigated using the Schedule for Nonadaptive and Adaptive Personality (SNAP; Clark, 1993) and SNAP-Collateral-Report Version. Participants were 189 well-acquainted undergraduate pairs (64% female; 83.2% Caucasian; age M = 19.7 years) of either same (n = 129) or mixed gender (n = 60). Self–peer agreement correlations averaged . 47 (range, .27–.62). Agreement variation across traits was associated with ratability (r = .58): Traits whose component items were judged more difficult to rate were associated with lower agreement. The degree to which the raters' own personality contributed to target ratings also was correlated negatively with agreement (r = −.60) and exhibited a strong relationship with ratability (r = −.73). Thus, when peers were asked to rate a target on difficult-to-judge traits, they reported more on their own personality, a phenomenon to which we apply the interpretive label the “self-based heuristic. ”
Folate Supplementation Limits the Aggressiveness of Glioma via the Remethylation of DNA Repeats Element and Genes Governing Apoptosis and Proliferation

Purpose: We have investigated whether the folate supplementation could be used to limit the aggressiveness of glioma through the DNA remethylation because (a) the cancer genome is characterized by a low level of DNA methylation (or 5-methylcytosine, 5 mC); and (b) folate is the main generator of S-adenosyl-methionine, the methyl donor molecule in the DNA methylation reaction catalyzed by the DNA methyltranferases. Experimental Design: The effects of folate supplementations were analyzed on the global DNA methylation status, the methylation status of DNA repeat element, the sensitivity of temozolomide-induced apoptosis, and the proliferation index of glioma cells. Finally, we analyzed whether the DNA methylation level could be used as a prognostic factor and/or a biomarker in an antiglioma therapy using folate supplementation as an adjuvant. Results: Our data show that gliomagenesis is accompanied by a reduction in 5 mC levels and that this low level of 5 mC is a poor prognostic factor in Glioblastoma Multiforme patients. We also show that folate supplementation enhanced the DNA remethylation through the Sp1/Sp3-mediated transcriptional up-regulation of genes coding for Dnmt3a and Dnmt3b proteins, two de novo methyltranferases. Finally, we show that the folate-induced DNA methylation limits proliferation and increases the sensitivity to temozolomide-induced apoptosis in glioma cells through methylation of the genes implicated in these processes (PDGF-B, MGMT, survivin, and bcl-w). Conclusion: This study suggests that folate supplementation could be a promising adjuvant for the future design of antiglioma therapies in preclinical and/or clinical studies.
Cognitive functioning and depressive symptoms in adolescents with inflammatory bowel disease.

AIM To investigate cognitive functioning and depressive symptoms in adolescents with inflammatory bowel disease (IBD). METHODS A neuropsychological test battery, including subtests of the Wechsler Adult Intelligence Scale-Revised and III, Wechsler Memory Scale-Revised, California Verbal Learning Test (CVLT), Stroop Color-Word Test, and Trail Making Test, which assessed verbal and visual short- and long-term memory, processing speed, logical reasoning, verbal intelligence, attention, and executive functioning, was administered to 13- to 19-year-old patients with IBD (n = 34; active disease n = 20). Depressive symptoms were measured with the Beck Depression Inventory. The findings were compared with peers with non-acute juvenile idiopathic arthritis (JIA; n = 23). Patients with coexisting psychiatric disorders were excluded. RESULTS The IBD group, especially patients in the acute phase, made more perseverative errors in the CVLT test that assessed verbal memory than the JIA group (6.0 ± 4.3 vs 3.3 ± 2.9, P < 0.01), but no other differences between the IBD and JIA groups were observed in the neuropsychological tests. The difference was close to statistical significance, even when glucocorticoid medication was controlled for (P < 0.052). The IBD group had more depressive symptoms than the JIA group (7.9 ± 7.6 vs 4.0 ± 4.0, P < 0.05). Approximately one third of the IBD group had at least mild depressive symptoms, and those with acute illness had the highest scores. However, depressive symptoms were not related to the difference in the verbal memory test (perseverative errors in the CVLT) between the IBD and JIA groups. CONCLUSION Adolescents with acute IBD may have mild verbal memory problems but no major cognitive deficits compared to peers with JIA.