Miracle-dz/UniFAR-FTUs huggingface dataset:
Do leptin levels predict weight gain?--A 5-year follow-up study in Mauritius. Mauritius Non-communicable Disease Study Group.

OBJECTIVE To investigate whether relative baseline leptin levels predict long-term changes in adiposity and/or its distribution. RESEARCH METHODS AND PROCEDURES In a longitudinal study of 2888 nondiabetic Mauritians aged 25 years to 74 years who participated in population-based surveys in 1987 and 1992, changes in body mass index (BMI), waist/hip ratio (WHR), and waist circumference were compared between "hyperleptinemic," "normoleptinemic," and "hypoleptinemic" groups. "Relative leptin levels" were calculated as standardized residuals from the regression of log10 leptin on baseline BMI to provide a leptin measure independent of BMI. Analyses were performed within each sex. A linear regression model was used to assess the effect of standardized residuals on changes in BMI, WHR, and waist circumference, independent of baseline BMI, age, fasting insulin, and ethnicity. RESULTS After adjusting for age and baseline BMI by analysis of covariance, there was no difference in changes in BMI, WHR, or waist circumference between men with low, normal, or high relative leptin levels. Among women, there was a significant difference in deltaWHR across leptin groups, such that the largest increase occurred in the "normal" leptin group. For both men and women, the linear regression models explained approximately 10% of variation in dependent variables, and the only significant independent variables were age, BMI, and being of Chinese origin, compared with Indian origin. DISCUSSION These findings do not support a role for leptin concentration in predicting weight gain or changes in fat distribution in adults over a 5-year period.
Experimental Study and Analysis of a Polymer Fiber Bragg Grating Embedded in a Composite Material

The characteristics of polymer fiber Bragg gratings (FBGs) embedded in composite materials are studied in this paper and are compared with characteristics of their silica counterparts. A polymer FBG of 10 mm length which exhibits a peak reflected wavelength circa 1530 nm is fabricated and characterized for this purpose. A silica FBG with a peak reflected wavelength circa 1553 nm is also embedded in the composite material for a comparison study. The fabricated composite material sample with embedded sensors is subjected to temperature and strain changes and the corresponding effects on the embedded polymer and silica FBGs are studied. The measured temperature sensitivity of the embedded polymer FBG was close to that of the same polymer FBG in free space, while the silica FBG shows elevated temperature sensitivity after embedding. With an increase in temperature, spectral broadening was observed for the embedded polymer FBG due to the stress induced by the thermal expansion of the composite material. From the observed wavelength shift and spectral bandwidth change of the polymer FBG, temperature and thermal expansion effects in the composite material can be measured simultaneously.
Ozone depletion at northern and southern latitudes derived from January 1979 to December 1991 Total Ozone Mapping Spectrometer data

Long-term ozone depletion rates (percentage change) have been computed from 13 years of Nimbus 7/Total Ozone Mapping Spectrometer (TOMS) data as a function of latitude, longitude, and month for the period January 1, 1979, to December 31, 1991. In both hemispheres the amount of ozone has decreased at latitudes above 30° by amounts that are larger than predicted by homogeneous chemistry models for the 13-year time period. The largest rates of ozone decrease occur in the southern hemisphere during winter and spring, with partial recovery during the summer and autumn. Outside of the Antarctic ozone hole region, the 12-year ozone depletion rates reach 8–10% per decade during the winter and spring at 55°S. Ozone depletion rates in excess of 7% per decade occur over populated regions in the southern hemisphere poleward of 45°S (southern Argentina and the tip of New Zealand) for 7 months of the year. Similar rates of decrease occur during northern winter and spring (6–8% at 55°N) over large populated regions. The enhanced zonal average ozone depletion rates at northern mid-latitudes (40–50°N) during January, February, and March, that correspond to five geographically localized regions of high ozone depletion rates, are probably associated with long-term dynamical or temperature changes. Only the equatorial band between ±20° shows little or no long-term ozone change since January 1979. Ozone time series data have been examined for effect of volcanic eruptions on stratospheric ozone observed by TOMS, with only the Mount Pinatubo stratospheric aerosol injection affecting ozone amounts for a few months after the eruption in June 1991. The TOMS data show no ozone perturbation after the El Chichon eruption, or after any of the other smaller equatorial eruptions, that cannot be explained by interference effects between the annual, El Nino/Southern Oscillation, and Quasi-Biennial Oscillation cycles. The effect of the stratospheric aerosol scattering phase function is clearly seen in the high spatial resolution TOMS ozone data after El Chichon and Mount Pinatubo. Errors caused by the short-term presence of stratospheric aerosols in the TOMS zonally averaged ozone data are less than 1% before correction, and have no significant effect on ozone trend determination.
Effects of tillage during the nonwaterlogged period on nitrous oxide and nitric oxide emissions in typical Chinese rice‐wheat rotation ecosystems

[1] Tillage practices result in major changes to soil environmental conditions and to the distribution of crop residues and nutrients in the soil profile, which may consequently affect the biogenic production and emission of N trace gases. To investigate the effects of tillage during the nonwaterlogged period on nitric oxide (NO) and nitrous oxide (N2O) emissions in rice-wheat rotation systems, we performed field experiments at three sites (Suzhou, Wuxi, and Jiangdu) in the Yangtze River Delta using static chamber techniques. The results showed that the effect of tillage on the emissions of both gases differed among the three field sites due to differences in agricultural management and soil texture. At the site with a light soil texture (Jiangdu: sandy loam), no tillage resulted in reduced NO emissions (0.5 kg N ha−1) as compared to conventionally tilled fields (0.9 kg N ha−1; p < 0.05). Regarding N2O, the no tillage plots showed significantly higher emissions (p < 0.05) in comparison to the tilled plots (3.9 versus 2.2 kg N ha−1) when the fields were merely amended with synthetic N fertilizers. However, this effect was not significant when wheat straw was used in addition to synthetic N fertilizers during the preceding rice season. In the clay loam soils (Wuxi), no tillage resulted in lower NO and higher N2O emissions from either N fertilized or unfertilized fields even though these results were not statistically significant. In the silty clay loam soils (Suzhou), which showed the highest soil organic carbon contents and the highest rates of N trace gas emissions in all three of the investigated sites, reduced tillage resulted in much higher NO emissions, whereas N2O emissions were not obviously influenced by tillage practices (reduced tillage versus tillage: NO, 9.5 versus 5.4 kg N ha−1; N2O, 10.6 versus 9.0 kg N ha−1). Similar effects of tillage were observed for the direct emission factors of the applied N during the wheat season. The observed emission factors for the different sites ranged from 0.3% to 2.4% for N2O (mean: 1.0%) and from 0.1% to 4.0% (mean: 0.9%) for NO, respectively. The observed site-to-site differences in emission factors are most likely the results of variations in soil properties (such as texture and pH) and agricultural practices (such as tillage and crop residue management) or in the amount and pattern of precipitation.
Comparison of legume-based cropping systems at Warra, Queensland. II.* Mineral nitrogen accumulation and availability to the subsequent wheat crop

Mineral nitrogen release following legume-based cropping systems for restoring the fertility of a Vertisol and the yield response and N uptake of subsequent wheat crops was studied. Legume phases of pastures, including a 4 year grass+legume ley, and lucerne and medic leys (~1 year) were terminated in October 1988 or 1989 and rotated with wheat. Chickpea-wheat rotations matched those of lucerne and medic leys. Mineral N accumulations during a subsequent fallow period were determined by core sampling to 1.5 m in October, February and May. Grain yield and N uptake of wheat enabled comparisons of the fertility restorative effects of the various systems relative to continuous wheat cropping. Averaged for two fallow periods, increases in mineral N down to 1.2 m depth were 93, 91, 68, and 37 kg/ha following grass+legume, lucerne and medic leys, and chickpea, respectively, compared with the continuous wheat treatment. Wheat yields were generally lower in 1989 (1.85–2.88 t/ha) than in 1990 (2.08–3.59 t/ha) following all leys and crops due to seasonal conditions. There was a grain yield increase of 0.11 and 0.52 t/ha in 1989 and 1.23 and 1.26 t/ha in 1990 following lucerne and medic leys, respectively and 0.85 t/ha in 1990 following a 4 year grass+legume ley. Following chickpea there was a yield increase of 0.81 and 1.36 t/ha in 1989 and 1990 respectively. Nitrogen uptake by wheat was increased by 40 and 49 kg/ha in 1989 and 48 and 58 kg/ha in 1990 following lucerne and medic leys respectively and 63 kg/ha in 1990 following a 4 year grass+legume ley. Following chickpea N uptake by wheat was increased by 27 and 32 kg/ha in 1989 and 1990 respectively. Grain protein concentration of wheat was substantially higher following all pasture leys (11.7–15.8%) than following wheat (8.0–9.4%) or chickpea (9.4–10.1%). Therefore, there was substantial evidence of the effectiveness of pasture leys in soil fertility restoration, as reflected in mineral N, yield response and N uptake by subsequent wheat crops.
The Role of Selective Information Processing in Price-Quality Inference

This research investigates the effects of the amount of information presented, information organization, and concern about closure on selective information processing and on the degree to which consumers use price as a basis for inferring quality. Consumers are found to be less likely to neglect belief-inconsistent information and their quality inferences less influenced by price when concern about closure is low (vs. high) and information is presented randomly (vs. ordered) or a small amount of information is presented. Results provide a picture of a resource-constrained consumer decision maker who processes belief-inconsistent information only when there is motivation and opportunity.
An Integrated Procedure to Assess the Stability of Coastal Rocky Cliffs: From UAV Close-Range Photogrammetry to Geomechanical Finite Element Modeling

The present paper explores the combination of unmanned aerial vehicle (UAV) photogrammetry and three-dimensional geomechanical modeling in the investigation of instability processes of long sectors of coastal rocky cliffs. The need of a reliable and detailed reconstruction of the geometry of the cliff surfaces, beside the geomechanical characterization of the rock materials, could represent a very challenging requirement for sub-vertical coastal cliffs overlooking the sea. Very often, no information could be acquired by alternative surveying methodologies, due to the absence of vantage points, and the fieldwork could pose a risk for personnel. The case study is represented by a 600 m long sea cliff located at Sant’Andrea (Melendugno, Apulia, Italy). The cliff is characterized by a very complex geometrical setting, with a suggestive alternation of 10 to 20 m high vertical walls, with frequent caves, arches and rock-stacks. Initially, the rocky cliff surface was reconstructed at very fine spatial resolution from the combination of nadir and oblique images acquired by unmanned aerial vehicles. Successively, a limited area has been selected for further investigation. In particular, data refinement/decimation procedure has been assessed to find a convenient three-dimensional model to be used in the finite element geomechanical modeling without loss of information on the surface complexity. Finally, to test integrated procedure, the potential modes of failure of such sector of the investigated cliff were achieved. Results indicate that the most likely failure mechanism along the sea cliff examined is represented by the possible propagation of shear fractures or tensile failures along concave cliff portions or over-hanging due to previous collapses or erosion of the underlying rock volumes. The proposed approach to the investigation of coastal cliff stability has proven to be a possible and flexible tool in the rapid and highly-automated investigation of hazards to slope failure in coastal areas.
Stability of the Human Papillomavirus Type 18 E2 Protein Is Regulated by a Proteasome Degradation Pathway through Its Amino-Terminal Transactivation Domain

ABSTRACT The E2 proteins of papillomaviruses regulate both viral transcription and DNA replication. The human papillomavirus type 18 (HPV18) E2 protein has been shown to repress transcription of the oncogenic E6 and E7 genes, inducing growth arrest in HeLa cells. Using HPV18 E2 fused to the green fluorescent protein (GFP), we showed that this protein was short-lived in transfected HeLa cells. Real-time microscopy experiments indicated that the E2-dependent signal increased for roughly 24 h after transfection and then rapidly disappeared, indicating that E2 was unstable in HeLa cells and could confer instability to GFP. Similar studies done with a protein lacking the transactivation domain indicated that this truncation strongly stabilizes the E2 protein. In vitro, full-length E2 or the transactivation domain alone was efficiently ubiquitinated, whereas deletion of the transactivation domain strongly decreased the ubiquitination of the E2 protein. Proteasome inhibition in cells expressing E2 increased its half-life about sevenfold, which was comparable to the half-life of the amino-terminally truncated protein. These characteristics of E2 instability were independent of the E2-mediated G1 growth arrest in HeLa cells, as they were reproduced in MCF7 cells, where E2 does not affect the cell cycle. Altogether, these experiments showed that the HPV18 E2 protein was degraded by the ubiquitin-proteasome pathway through its amino-terminal transactivation domain. Tight regulation of the stability of the HPV 18 E2 protein may be essential to avoid accumulation of a potent transcriptional repressor and antiproliferative agent during the viral vegetative cycle.
Nonsterol Triterpenoids as Major Constituents of Olea europaea

Plant triterpenoids represent a large and structurally diverse class of natural products. A growing interest has been focused on triterpenoids over the past decade due to their beneficial effects on human health. We show here that these bioactive compounds are major constituents of several aerial parts (floral bud, leaf bud, stem, and leaf) of olive tree, a crop exploited so far almost exclusively for its fruit and oil. O. europaea callus cultures were analyzed as well. Twenty sterols and twenty-nine nonsteroidal tetra- and pentacyclic triterpenoids belonging to seven types of carbon skeletons (oleanane, ursane, lupane, taraxerane, taraxastane, euphane, and lanostane) were identified and quantified by GC and GC-MS as free and esterified compounds. The oleanane-type compounds, oleanolic acid and maslinic acid, were largely predominant in all the organs tested, whereas they are practically absent in olive oil. In floral buds, they represented as much as 2.7% of dry matter. In callus cultures, lanostane-type compounds were the most abundant triterpenoids. In all the tissues analyzed, free and esterified triterpene alcohols exhibited different distribution patterns of their carbon skeletons. Taken together, these data provide new insights into largely unknown triterpene secondary metabolism of Olea europaea.
Operational cloud classification for the Iberian Peninsula using Meteosat Second Generation and AQUA-AIRS image fusion

The aim of this work was the adaptation and improvement of a previous cloud detection and classification algorithm that was developed for the Meteosat-7 satellite. The functions of this satellite have now been taken on by the new series of Meteosat Second Generation (MSG) satellites, which are not just replicas but new, much improved versions of their predecessor. The formerly used Advanced/Tiros-N Operational Vertical Sounder (A/TOVS) probe has also been superseded technologically by new sensors with better spatial resolution, capable of carrying out more accurate measurements at a greater number of wavelengths. This is the case of the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor onboard the TERRA and AQUA satellites and of the Atmospheric Infrared Sounder (AIRS) probe. In this context, new potential improvements are analysed for this algorithm by using these new platforms and sensors and the results are compared to those obtained in the first classification.
Enabling interaction with single user applications through speech and gestures on a multi-user tabletop

Co-located collaborators often work over physical tabletops with rich geospatial information. Previous research shows that people use gestures and speech as they interact with artefacts on the table and communicate with one another. With the advent of large multi-touch surfaces, developers are now applying this knowledge to create appropriate technical innovations in digital table design. Yet they are limited by the difficulty of building a truly useful collaborative application from the ground up. In this paper, we circumvent this difficulty by: (a) building a multimodal speech and gesture engine around the Diamond Touch multi-user surface, and (b) wrapping existing, widely-used off-the-shelf single-user interactive spatial applications with a multimodal interface created from this engine. Through case studies of two quite different geospatial systems -- Google Earth and Warcraft III -- we show the new functionalities, feasibility and limitations of leveraging such single-user applications within a multi user, multimodal tabletop. This research informs the design of future multimodal tabletop applications that can exploit single-user software conveniently available in the market. We also contribute (1) a set of technical and behavioural affordances of multimodal interaction on a tabletop, and (2) lessons learnt from the limitations of single user applications.
Uncertainty and sensitivity analysis of coastal flood damage estimates in the west of the Netherlands

Abstract. Uncertainty analyses of flood damage assessments generally require a large amount of model evaluations. This is often hampered by the high computational costs necessary to calculate flood extents and depths using 2-dimensional flow models. In this paper we developed a new approach to estimate flood inundation depths that can be incorporated in a Monte Carlo uncertainty analysis. This allows estimation of the uncertainty in flood damage estimates and the determination of which parameters contribute the most to this uncertainty. The approach is applied on three breach locations on the west coast of the Netherlands. In total, uncertainties in 12 input parameters were considered in this study, related to the storm surge, breach growth and the damage calculation. We show that the uncertainty in flood damage estimates is substantial, with the bounds of the 95% confidence range being more than four times smaller or larger than the median. The most influential parameter is uncertainty in depth-damage curves, but five other parameters also contribute substantially. The contribution of uncertainty in parameters related to the damage calculation is about equal to the contribution of parameters related to the volume of the inflowing water. Given the emphasis of most risk assessments on the estimation of the hazard, this implies that the damage calculation aspect deserves more attention in flood risk research efforts. Given the large uncertainties found in this study, it is recommended to always perform multiple calculations in flood simulations and damage assessments to capture the full range of model outcomes.
Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors.

PURPOSE The goal of this study was to identify potential protein markers in lung adenocarcinomas. EXPERIMENTAL DESIGN A series of 93 lung adenocarcinomas (64 stage I and 29 stage III) and 10 uninvolved lung samples were examined for quantitative differences in protein expression using two-dimensional PAGE. Candidate proteins were identified using matrix-assisted laser desorption/ionization mass spectrometry or peptide sequencing. The levels of the individual isoforms of nine proteins found to be overexpressed in the lung tumors were examined. Potential mechanisms for overexpression were examined by comparing mRNA expression levels, assessed using oligonucleotide arrays, to the protein values in the same samples. RESULTS Antioxidant enzyme AOE372, ATP synthase subunit d (ATP5D), beta1,4-galactosyltransferase, cytosolic inorganic pyrophosphatase, glucose-regulated M(r) 58,000 protein, glutathione-S-transferase M4, prolyl 4-hydroxylase beta subunit, triosephosphate isomerase, and ubiquitin thiolesterase (UCHL1) were identified as being significantly overexpressed in lung adenocarcinomas. The expression of these proteins was increased from 1.4- to 10.6-fold as compared with uninvolved lung tissue. The expression of the individual protein isoforms was correlated with 10 clinicopathological variables as well as with each gene's mRNA level in the same sample. Both isoforms of glucose-regulated M(r) 58,000 protein were found to be significantly correlated with their mRNA expression profiles (P < 0.05), indicating that increased transcription likely underlies the increased expression of these proteins. CONCLUSIONS Two-dimensional PAGE and mass spectrometry can identify proteins showing increased expression in lung adenocarcinoma. The association of specific isoforms of these proteins with clinical variables and understanding the regulation of their expression will aid in determination of their potential use as biomarkers in this cancer.
Characterization of Rhizobium phaseoli Sym plasmid regions involved in nodule morphogenesis and host‐range specificity

Two nodulation regions from the symbiotic plasmid (pSym) of Rhizobium phaseoil CE‐3 were identified. The two regions were contained in overlapping cosmids pSM927 and pSM991. These cosmids, in a R phaseoli pSym‐cured strain background, induced ineffective nodules on Phaseolus vulgaris roots.