Miracle-dz/UniFAR-FTUs huggingface dataset:
Continuous Combined Estrogen Plus Progestin and Endometrial Cancer: The Women's Health Initiative Randomized Trial.

BACKGROUND While progestin addition to estrogen mitigates endometrial cancer risk, the magnitude of the effect on incidence, specific endometrial cancer histologies, and endometrial cancer mortality remains unsettled. These issues were assessed by analyses after extended follow-up of the Women's Health Initiative (WHI) randomized clinical trial evaluating continuous combined estrogen plus progestin use. METHODS The WHI enrolled 16 608 postmenopausal women into a randomly assigned, double-blind, placebo-controlled trial. Women age 50 to 79 years with intact uteri with normal endometrial biopsy at entry were randomly assigned to once-daily 0.625 mg conjugated equine estrogen plus 2.5mg medroxyprogesterone acetate (n = 8506) as a single pill or matching placebo (n = 8102). Follow-up beyond the original trial completion date required reconsent, obtained from 12 788 (83%) of surviving participants. Analyses were by intent-to-treat. All statistical tests were two-sided. RESULTS After 5.6 years' median intervention and 13 years' median cumulative follow-up, there were fewer endometrial cancers in the combined hormone therapy compared with the placebo group (66 vs 95 case patients, yearly incidence, 0.06% vs 0.10%; hazard ratio [HR] = 0.65, 95% confidence interval [CI] = 0.48 to 0.89, P = .007). While there were somewhat fewer endometrial cancers during intervention (25 vs 30, respectively; HR = 0.77, 95% CI = 0.45 to 1.31), the difference became statistically significant postintervention (41 vs 65, respectively; HR = 0.59, 95% CI = 0.40 to 0.88, P = .008), but hazard ratios did not differ between phases (P difference = .46). There was a statistically nonsignificant reduction in deaths from endometrial cancer in the estrogen plus progestin group (5 vs 11 deaths, HR = 0.42, 95% CI = 0.15 to 1.22). CONCLUSION In postmenopausal women, continuous combined estrogen plus progestin decreases endometrial cancer incidence.
Parasites and chronic renal failure

Suppression of the human immune system results in an increase in susceptibility to infection by various infectious agents. Conditions such as AIDS, organ transplantation and chronic renal insufficiency (CRI) are the most important cause of insufficient immune response against infections. Long term renal disorders result in uremia, which can suppress human immune system. Parasitic infections are one of the most important factors indicating the public health problems of the societies. These infections can be more hostile and life threatening in susceptible individuals than in the normal people. In these patients some parasitic infections such as blastocystiosis, cryptosporidiosis and toxoplasmosis have been reported to be more prevalent. This review aimed to give an overview about parasitic infections in patients with renal disorders.
Impact of intrauterine growth restriction on preterm lung disease

Intrauterine growth restriction (IUGR) is an important cause for prematurity and adversely influences prematurity‐related morbidities. This study evaluates the impact of IUGR on respiratory outcomes in infants <32 weeks with IUGR and birthweight <10th centile (SGA) compared to matched appropriate for gestation (AGA) controls.
Strong Key-Exposure Resilient Auditing for Secure Cloud Storage

Key exposure is one serious security problem for cloud storage auditing. In order to deal with this problem, cloud storage auditing scheme with key-exposure resilience has been proposed. However, in such a scheme, the malicious cloud might still forge valid authenticators later than the key-exposure time period if it obtains the current secret key of data owner. In this paper, we innovatively propose a paradigm named strong key-exposure resilient auditing for secure cloud storage, in which the security of cloud storage auditing not only earlier than but also later than the key exposure can be preserved. We formalize the definition and the security model of this new kind of cloud storage auditing and design a concrete scheme. In our proposed scheme, the key exposure in one time period doesn’t affect the security of cloud storage auditing in other time periods. The rigorous security proof and the experimental results demonstrate that our proposed scheme achieves desirable security and efficiency.
Spectral Properties of Gas-phase Condensed Fullerene-like Carbon Nanoparticles from Far-ultraviolet to Infrared Wavelengths

Carbon solids are ubiquitous material in interstellar space. However, the formation pathway of carbonaceous matter in astrophysical environments, as well as in terrestrial gas-phase condensation reactions, is not yet understood. Laser ablation of graphite in different quenching gas atmospheres, such as pure He, He/H2, and He/H2O at varying pressures, is used to synthesize very small, fullerene-like carbon nanoparticles. The particles are characterized by very small diameters between 1 and 4 nm and a disturbed onion-like structure. The soot particles extracted from the condensation zone obviously represent a very early stage of particle condensation. The spectral properties have been measured from the far-ultraviolet (FUV; λ = 120 nm) to the mid-infrared (MIR; λ = 15 μm). The seedlike soot particles show strong absorption bands in the 3.4 μm range. The profile and the intensity pattern of the 3.4 μm band of the diffuse interstellar medium can be well reproduced by the measured 3.4 μm profile of the condensed particles; however, all the carbon which is left to form solids is needed to fit the intensity of the interstellar bands. In contrast to the assumption that onion-like soot particles could be the carriers of the interstellar ultraviolet (UV) bump, our very small onion-like carbon nanoparticles do not show distinct UV bands due to (π-π*) transitions.
Introduction to clinical pathology: A brief course of laboratory medicine in the field for medical students

OBJECTIVES: Teaching of clinical pathology to medical students has been ignored in many countries such as Iran. We aim to introduce a practical brief course and its proper timing. MATERIALS AND METHODS: Three groups of medical students from consecutive years of entrance passed a 1.5 working day practical course on the field. Their level of knowledge was assessed by pre- and post-tests. Their idea and satisfaction were gathered by questionnaires. RESULTS: Knowledge of students became significantly higher after the course. Their satisfaction was high. Students in later year of education got significantly higher marks. Most of the students wished such a course should be away from basic sciences period and as near as possible to internship. DISCUSSION: Due to overloaded curriculum of general medicine in Iran, we decided to run a brief practical course of laboratory medicine education for medical students. Although the course was practical, the knowledge of students became higher. Students with more clinical experience and knowledge absorbed more. Being actively involved in the classes lit the enthusiasm of students and made them satisfied with the course. It seemed that the course should be placed in later years of clinical training to get the best uptake and results.
Prevalence and Predictors of Poor Sleep Quality in Mild Cognitive Impairment

Aims: To investigate the prevalence of and contributors to poor sleep quality in patients with mild cognitive impairment (MCI). Methods: Data were collected for 158 patients meeting the criteria for MCI. Measures included the Pittsburgh Sleep Quality Index, Geriatric Depression Scale, and Mini-Mental State Examination. Demographic, lifestyle, medication, and substance use data were also collected. Results: A total of 63% of patients with MCI demonstrated sleep disturbance, a significantly higher rate than that of the controls (44%; chi-square = 8.77; P = .003). Depressive symptoms, cognition, antidepressant usage, alcohol consumption, age, and education were identified as significant predictors of self-reported sleep quality in patients with MCI (R 2 = .327, F 6,145 = 11.729, P < .0001). Conclusions: Sleep disturbance occurs in around two-thirds of patients with MCI. Interventions addressing depression, cognition, and substance and medication use may improve sleep quality in MCI.
Calculous disease of the vermiform appendix.

The formation of true calculi within the lumen of the vermiform appendix is a comparatively rare event, but the condition is of clinical importance because of the frequency with which such calculi give rise to serious complications. The main clinico-pathological features of calculous disease of the appendix, based on the examination of 2,000 appendix specimens, are presented in this report with the following objectives in view: to clarify the terminology of the various formed faecal objects which are found in the lumen of the appendix; to assess the incidence of calculous disease and its complications; to draw the attention of surgeons, radiologists, and pathologists to a disease which deserves wider recognition.
Design and Evaluation of a Disulphide-crosslinked Hyaluronan Hydrogel for Regeneration of the Intervertebral Disc

A cysteine-containing elastin-like polypeptide (ELP2cys) was successfully synthesized and purified, and was shown to behave in a similar fashion to other well-characterized ELPs. Incorporating the ELP2cys as a crosslinking agent into a solution of sulphated hyaluronan (CMHA-S) not only decreased the gelation time of the solution but also increased the crosslinking density of the resultant hydrogel, in turn increasing both the resiliency and stiffness of the construct. Preliminary in vitro work involved culture of human disc cells, followed by their encapsulation within the hydrogel. Unfortunately the results were inconclusive, although it appeared as though the addition of ELP2cys to the matrix did not negatively affect the viability of the cells, as compared to hydrogels with CMHA-S only. This study showed that ELP2cys is a valuable addition to the family of recombinant elastin-like polypeptides, and shows promise as a crosslinking agent in the formation of hyaluronan hydrogels.
Satisfaction with care among low-income women with breast cancer.

BACKGROUND Patient satisfaction is an important outcome measure in determining quality of care. There are few data evaluating patient satisfaction in nonwhite, low-income populations. The objective of this study was to identify the structure, process, and outcome factors that impact patient satisfaction with care in a low-income population of women with breast cancer. METHODS In a cross-sectional survey of low-income women newly diagnosed with breast cancer, eligible women enrolled in the California Breast and Cervical Cancer Treatment Program (BCCTP) from February 2003 through September 2005 were interviewed by phone 6 months after their enrollment. This was a population-based sample of women aged >or=18 years (n = 924) with a definitive diagnosis of breast cancer and enrolled in the BCCTP. The main outcome measure was satisfaction with care received. RESULTS Random effects logistic regression revealed that less acculturated Latinas were more likely (odds ratio, [OR] = 5.36, p < 0.000) to be extremely satisfied with their care compared with non-Hispanic white women. Women who believed they could have been diagnosed sooner were less likely to be extremely satisfied (OR = 0.61, p < 0.000). Women who had received or were receiving radiotherapy or chemotherapy had nearly twice the odds of being extremely satisfied (OR = 2.02, p < 0.000, and OR = 2.13, p < 0.000, respectively). Greater information giving was associated with greater satisfaction (OR = 1.17, p < 0.000). Women reporting greater physician emotional support were more likely to report being extremely satisfied (OR = 1.26, p < 0.000). A higher participatory treatment decision-making score was associated with greater satisfaction (OR = 1.78, p < 0.000). CONCLUSIONS In a low-income population, satisfaction is also reported at high levels. In addition to age, ethnicity/acculturation, receipt of chemotherapy and radiotherapy, physician emotional support, and collaborative decision making, perception of diagnostic delay is a predictor of dissatisfaction in this population.
Unveiling a phytoplankton hotspot at a narrow boundary between coastal and offshore waters

In terrestrial ecosystems, transitional areas between different plant communities (ecotones) are formed by steep environmental gradients and are commonly characterized by high species diversity and primary productivity, which in turn influences the foodweb structure of these regions. Whether comparable zones of elevated diversity and productivity characterize ecotones in the oceans remains poorly understood. Here we describe a previously hidden hotspot of phytoplankton diversity and productivity in a narrow but seasonally persistent transition zone at the intersection of iron-poor, nitrate-rich offshore waters and iron-rich, nitrate-poor coastal waters of the Northeast Pacific Ocean. Novel continuous measurements of phytoplankton cell abundance and composition identified a complex succession of blooms of five distinct size classes of phytoplankton populations within a 100-km–wide transition zone. The blooms appear to be fueled by natural iron enrichment of offshore communities as they are transported toward the coast. The observed succession of phytoplankton populations is likely driven by spatial gradients in iron availability or time since iron enrichment. Regardless of the underlying mechanism, the resulting communities have a strong impact on the regional biogeochemistry as evidenced by the low partial pressure of CO2 and the nearly complete depletion of nutrients. Enhanced phytoplankton productivity and diversity associated with steep environmental gradients are expected wherever water masses with complementary nutrient compositions mix to create a region more favorable for phytoplankton growth. The ability to detect and track these important but poorly characterized marine ecotones is critical for understanding their impact on productivity and ecosystem structure in the oceans.
Canonical structure of topologically massive gravity with a cosmological constant

We study the canonical structure of three-dimensional topologically massive gravity with a cosmological constant, using the full power of Dirac's method for constrained Hamiltonian systems. It is found that the dimension of the physical phase space is two per spacetime point, which corresponds to a single Lagrangian degree of freedom. The analysis of the AdS asymptotic region reveals a remarkable relation to 3D gravity with torsion: in the limit of vanishing torsion, the conserved charges and asymptotic symmetries of the two theories become identical.
Randomized Quantization and Source Coding With Constrained Output Distribution

This paper studies fixed-rate randomized vector quantization under the constraint that the quantizer's output has a given fixed probability distribution. A general representation of randomized quantizers that includes the common models in the literature is introduced via appropriate mixtures of joint probability measures on the product of the source and reproduction alphabets. Using this representation and results from optimal transport theory, the existence of an optimal (minimum distortion) randomized quantizer having a given output distribution is shown under various conditions. For sources with densities and the mean square distortion measure, it is shown that this optimum can be attained by randomizing quantizers having convex codecells. For stationary and memoryless source and output distributions, a rate-distortion theorem is proved, providing a single-letter expression for the optimum distortion in the limit of large blocklengths.
Eai European Alliance for Innovation Motion Sensor Technologies in Education

This paper attempts to raise a discussion regarding motion sensor technologies, mainly seen as peripherals of contemporary video game consoles, by examining their exploitation within educational context. An overview of the existing literature is presented, while attempting to categorize the educational approaches which involve motion sensor technologies, in two parts. The first one concerns the education of people with special needs. The utilization of motion sensor technologies, incorporated by game consoles, in the education of such people is examined. The second one refers to various educational approaches in regular education, under which not so many research approaches, but many teaching ideas can be found. The aim of the paper is to serve as a reference point for every individual/group, willing to explore the Sensor-Based Games Based Learning (SBGBL) research area, by providing a complete and structured literature review. and reproduction in any medium so long as the original work is properly cited.
Assessing racial/ethnic disparities in treatment across episodes of mental health care.

OBJECTIVE To investigate disparities in mental health care episodes, aligning our analyses with decisions to start or drop treatment, and choices made during treatment. STUDY DESIGN We analyzed whites, blacks, and Latinos with probable mental illness from Panels 9-13 of the Medical Expenditure Panel Survey, assessing disparities at the beginning, middle, and end of episodes of care (initiation, adequate care, having an episode with only psychotropic drug fills, intensity of care, the mixture of primary care provider (PCP) and specialist visits, use of acute psychiatric care, and termination). FINDINGS Compared with whites, blacks and Latinos had less initiation and adequacy of care. Black and Latino episodes were shorter and had fewer psychotropic drug fills. Black episodes had a greater proportion of specialist visits and Latino episodes had a greater proportion of PCP visits. Blacks were more likely to have an episode with acute psychiatric care. CONCLUSIONS Disparities in adequate care were driven by initiation disparities, reinforcing the need for policies that improve access. Many episodes were characterized only by psychotropic drug fills, suggesting inadequate medication guidance. Blacks' higher rate of specialist use contradicts previous studies and deserves future investigation. Blacks' greater acute mental health care use raises concerns over monitoring of their treatment.
RNA Activation of the Vascular Endothelial Growth Factor Gene (VEGF) Promoter by Double-Stranded RNA and Hypoxia: Role of Noncoding VEGF Promoter Transcripts

ABSTRACT RNA activation (RNAa) is a gene regulation process in which promoter-targeted short double-stranded RNAs (dsRNAs) or microRNAs (miRs) induce target gene expression at the transcriptional level. Here, we investigate the presence of cryptic promoter transcripts within the VEGF promoter. Single-strand sense and antisense noncoding vascular endothelial growth factor (NcVEGF) promoter transcripts are identified, and their respective expression is studied in cells transfected with a VEGF promoter targeted dsRNA, namely, dsVEGF706, in hypoxic cells and in human malignant lung tissues. Interestingly, in dsVEGF706-transfected, as well as in hypoxic cells, NcVEGF expression levels increase coordinately with coding VEGF expression. Ago2 interaction with both sense and antisense NcVEGFs is increased in hypoxic cells, whereas in dsVEGF706-transfected cells, Ago2 and the antisense strand of the dsRNA interact specifically with the sense NcVEGF transcript. Furthermore, both dsVEGF706 and ectopic NcVEGF transcripts are able to activate the VEGF promoter endogenously present or in a reporter construct. Finally, using small interfering RNA targeting Ago2, we show that RNAa plays a role in the maintenance of increased VEGF and NcVEGF expression after hypoxia. Given the central role of VEGF in major human diseases, including cancer, this novel molecular mechanism is poised to reveal promising possibilities for therapeutic interventions.
Trials of NIH's AIDS Vaccine Get a Yellow Light

AIDS RESEARCHPOTOMAC, MARYLAND-- Last week, the U.S. National Institutes of Health's AIDS Vaccine Research Subcommittee met here to discuss the future of an AIDS vaccine made by NIH after a test of a similar vaccine found that it may have actually increased some people's risk of becoming infected with HIV.
Lumican, a small leucine‐rich proteoglycan

Lumican belongs to the family of small leucine‐rich repeat proteoglycans. Recent studies have shown that lumican participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of lumican has been correlated to the growth and metastasis of various malignancies; however, its exact role in tumorogenesis remains elusive. This review focuses upon the role of lumican in cell biology, providing insights into molecular mechanisms that lumican likely utilizes to control processes relevant to tumorogenesis. © 2008 IUBMB IUBMB Life, 60(12): 818–823, 2008
Orexin A Induces GnRH Gene Expression and Secretion from GT1-7 Hypothalamic GnRH Neurons

Orexin A, a recently discovered hypothalamic peptide, has been shown to have a stimulatory effect on release of gonadotropin-releasing hormone (GnRH) from rat hypothalamic explants in vitro. However, it is presently unclear whether in vivo this effect is mediated directly at the level of the GnRH neuron, or via multiple afferent neuronal connections. Therefore, in the present study, we investigated the direct action of orexin A on GnRH neurons using the immortalized GnRH-secreting GT1-7 hypothalamic cells. Orexin-1 receptor (OX1R) expression was detected in GT1-7 cells by RT-PCR and Western blot. Results showed that 0.1–1 nM orexin A, when administered in culture media for 4 h, can significantly stimulate GnRH mRNA expression in GT1-7 cells (p < 0.05). Administration of 1 µM OX1R antagonist, SB-334867, completely blocked the observed orexin A responses in these cells, indicating that orexin A stimulation of GnRH neurons is specifically through OX1R. Moreover, 0.1 nM orexin A stimulated GnRH release after 30–45 min. To examine possible signal transduction pathways involved in mediating these effects, a MEK inhibitor (UO-126), PKC inhibitor (calphostin C), and PKA inhibitor (H-89), were used, with each blocking orexin A-induced GnRH transcription and release from immortalized cells. Collectively, our results show that orexin A is capable of directly stimulating GnRH transcription and neuropeptide release from these immortalized hypothalamic neurons, and that the effects of orexin A appear to be mediated via the OX1R, coupled with activation of the PKC-, MAPK- and PKA-signaling pathways. It is suggested that the stimulatory effect of orexin A on GnRH transcription and release may also occur directly at the level of GnRH neurons in vivo.
Topological liquid diode

Janus gate: A unique topology blocks the flow of water in one direction but makes it run fast in the opposite direction. The last two decades have witnessed an explosion of interest in the field of droplet-based microfluidics for their multifarious applications. Despite rapid innovations in strategies to generate small-scale liquid transport on these devices, the speed of motion is usually slow, the transport distance is limited, and the flow direction is not well controlled because of unwanted pinning of contact lines by defects on the surface. We report a new method of microscopic liquid transport based on a unique topological structure. This method breaks the contact line pinning through efficient conversion of excess surface energy to kinetic energy at the advancing edge of the droplet while simultaneously arresting the reverse motion of the droplet via strong pinning. This results in a novel topological fluid diode that allows for a rapid, directional, and long-distance transport of virtually any kind of liquid without the need for an external energy input.