Miracle-dz/UniFAR-FTUs huggingface dataset:
Correction: Multigene Assessment of the Species Boundaries and Sexual Status of the Basidiomycetous Yeasts Cryptococcus flavescens and C. terrestris (Tremellales)

Cryptococcus flavescens and C. terrestris are phenotypically indistinguishable sister species that belong to the order Tremellales (Tremellomycetes, Basidiomycota) and which may be mistaken for C. laurentii based on phenotype. Phylogenetic separation between C. flavescens and C. terrestris was based on rDNA sequence analyses, but very little is known on their intraspecific genetic variability or propensity for sexual reproduction. We studied 59 strains from different substrates and geographic locations, and used a multilocus sequencing (MLS) approach complemented with the sequencing of mating type (MAT) genes to assess genetic variation and reexamine the boundaries of the two species, as well as their sexual status. The following five loci were chosen for MLS: the rDNA ITS-LSU region, the rDNA IGS1 spacer, and fragments of the genes encoding the largest subunit of RNA polymerase II (RPB1), the translation elongation factor 1 alpha (TEF1) and the p21-activated protein kinase (STE20). Phylogenetic network analyses confirmed the genetic separation of the two species and revealed two additional cryptic species, for which the names Cryptococcus baii and C. ruineniae are proposed. Further analyses of the data revealed a high degree of genetic heterogeneity within C. flavescens as well as evidence for recombination between lineages detected for this species. Strains of C. terrestris displayed higher levels of similarity in all analysed genes and appear to make up a single recombining group. The two MAT genes (STE3 and SXI1/SXI2) sequenced for C. flavescens strains confirmed the potential for sexual reproduction and suggest the presence of a tetrapolar mating system with a biallelic pheromone/receptor locus and a multiallelic HD locus. In C. terrestris we could only sequence STE3, which revealed a biallelic P/R locus. In spite of the strong evidence for sexual recombination in the two species, attempts at mating compatible strains of both species on culture media were unsuccessful.
An interpretative phenomenological analysis of academically resilient Hispanic graduate and post-graduate students

This study examined the academic resilience of 14 Hispanic graduate and post-graduate students from across the country. The participants studied a variety of academic disciplines and comprised a broad spectrum of ethnicities. This study applied interpretative phenomenological analysis (IPA) as a qualitative tool to investigate the participants’ lived experiences. The research questions focused on academic success from a sociocultural perspective. The data were analyzed through the lens of resilience theory and applied Latino critical race-based constructs as protective barriers. The study revealed that Hispanic students utilized protective factors to remain resilient against several barriers and stressors experienced in educational settings and programs. This study confirmed that Hispanic students acquire academic survival skills primarily from their peers and in communities of minority students, a finding that requires additional investigation. Moreover, this study found that inclusive academic services are needed for Hispanic students to avert discrimination and feelings of isolation. In this study, only half of the participants perceived that their educational environments fulfilled their needs. Furthermore, the study confirmed the findings of literature that family support, or familial capital, is essential to Hispanic students. This study also produced unique findings that require further investigation. The participants remained academically strong by enculturating rather than assimilating into the dominant culture. In essence, they maintained academic resilience by adapting bicultural competence, which produced a desire to aid other Hispanic students and give back to the community by paying it forward, a finding that requires additional research.
Ghrelin Attenuates Intestinal Barrier Dysfunction Following Intracerebral Hemorrhage in Mice

Intestinal barrier dysfunction remains a critical problem in patients with intracerebral hemorrhage (ICH) and is associated with poor prognosis. Ghrelin, a brain-gut peptide, has been shown to exert protection in animal models of gastrointestinal injury. However, the effect of ghrelin on intestinal barrier dysfunction post-ICH and its possible underlying mechanisms are still unknown. This study was designed to investigate whether ghrelin administration attenuates intestinal barrier dysfunction in experimental ICH using an intrastriatal autologous blood infusion mouse model. Our data showed that treatment with ghrelin markedly attenuated intestinal mucosal injury at both histomorphometric and ultrastructural levels post-ICH. Ghrelin reduced ICH-induced intestinal permeability according to fluorescein isothiocyanate conjugated-dextran (FITC-D) and Evans blue extravasation assays. Concomitantly, the intestinal tight junction-related protein markers, Zonula occludens-1 (ZO-1) and claudin-5 were upregulated by ghrelin post-ICH. Additionally, ghrelin reduced intestinal intercellular adhesion molecule-1 (ICAM-1) expression at the mRNA and protein levels following ICH. Furthermore, ghrelin suppressed the translocation of intestinal endotoxin post-ICH. These changes were accompanied by improved survival rates and an attenuation of body weight loss post-ICH. In conclusion, our results suggest that ghrelin reduced intestinal barrier dysfunction, thereby reducing mortality and weight loss, indicating that ghrelin is a potential therapeutic agent in ICH-induced intestinal barrier dysfunction therapy.
Invasive aspergillosis caused by Aspergillus terreus: an emerging opportunistic infection with poor outcome independent of azole therapy.

OBJECTIVES Invasive aspergillosis (IA) caused by Aspergillus terreus is a significant cause of morbidity and mortality in patients with haematological malignancy (HM). Very few data are available in this patient population to differentiate IA patients with A. terreus from those with non-terreus species of Aspergillus to compare outcomes. We retrospectively investigated 513 HM patients who were treated for either definite or probable IA between June 1993 and August 2012 in a cancer centre. METHODS We compared baseline characteristics, antifungal therapies and outcomes between patients infected with A. terreus (n = 96, 18.7%) and those infected with non-terreus Aspergillus species (n = 335, 65.3%). Eighty-one patients with mixed or unspecified Aspergillus infections were excluded. RESULTS Breakthrough infections occurred more frequently in the A. terreus group (91% versus 77%, P = 0.009). A. terreus infection was associated with a lower rate of final response to antifungal therapy (21% versus 38%, P = 0.0015) and a higher rate of IA-associated mortality (51% versus 30%, P < 0.001). Multivariate analyses showed that these associations were independent of patients' clinical characteristics and the antifungal regimens they received. Factors independently associated with final response included treatment with azoles (OR 3.1, 95% CI 1.9-5.0, P < 0.0001) and Aspergillus species (A. terreus versus non-terreus Aspergillus species) (OR 0.5, 95% CI 0.3-0.98, P = 0.043). Additionally, Aspergillus species and treatment with azoles were independently associated with IA-associated mortality. CONCLUSIONS A. terreus IA in HM patients was associated with worse outcome than IA caused by non-terreus Aspergillus species. Poor prognosis in patients with invasive A. terreus infections is independent of anti-Aspergillus azole-based treatment.
TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells

TMEPAI/PMEPA1 is a transmembrane protein that was originally identified as a prostatic RNA, the synthesis of which is induced by testosterone or its derivatives. We have recently identified TMEPAI as a direct target gene of transforming growth factor‐β (TGF‐β)/Smad signaling that participates in negative feedback control of the duration and intensity of TGF‐β/Smad signaling. TMEPAI is constitutively and highly expressed in many types of cancer and is associated with poor prognosis. Here, we report that TMEPAI is highly expressed in the lung adenocarcinoma cell lines Calu3, NCI‐H23, and RERF‐LC‐KJ. Expression of TMEPAI in these cancer cells was significantly suppressed by a TGF‐β receptor kinase antagonist, SB208, and by TGF‐β neutralizing antibodies. These results suggest that constitutive expression of TMEPAI in these cancer cells depends on autocrine TGF‐β stimulation. Knockdown of TMEPAI in Calu3 and NCI‐H23 cells enhanced levels of Smad2 phosphorylation and significantly suppressed cell proliferation in the presence of TGF‐β, indicating that highly expressed TMEPAI suppresses levels of Smad phosphorylation in these cancer cells and reduces the growth inhibitory effects of TGF‐β/Smad signaling. Furthermore, knockdown of TMEPAI in Calu3 and NCI‐H23 cells suppressed sphere formation in vitro and tumor formation in s.c. tissues and in lungs after tail vein injection in NOD‐SCID mice in vivo. Together, these experiments indicate that TMEPAI promotes tumorigenic activities in lung cancer cells.
HUBUNGAN DUKUNGAN KELUARGA DENGAN DERAJAT HIPERTENSI PADA PASIEN HIPERTENSI Di PUSKESMAS RANOMUUT KOTA MANADO

pressure ≥ 140/90 mmHg. Family support is a form of behavior airport by the family in the form of emotional support, appreciation / appraisal, informational and instrumental to the family when healthy or sick. The purpose of the research is to analyze the association between family support and hypertension degrees of the patients with hypertension at Puskesmas Ranomuut Manado. The method of research is analytical descriptive with a cross-sectional design. The sample-taking technique in the research is purposive sampling with 68 samples. The collecting of data is done using a questionnaire. The processing of data uses the software computer with chi-square with the level of confidence interval of 95% (α=0,05). The results of the research shows the number of respondents with a high level family support of patients with hypertension is 39 respondents (57.4%), and the patients with pre classification of hypertension is 37 respondents (54.4%) and the patients with the classification of hypertension is 31 respondents (45.6% ) and there is p value 0.000. This conclusion shows that there is a relationship between family support and hypertension degrees of the patients with hypertension. The recommendation for further research can be a reference for more research on hypertension degrees of the patients with hypertension with other variables such as motivation, self-care and others. Keywords : Family Support, Hypertension Abstrak: Hipertensi merupakan masalah kesehatan yang serius yang ditandai dengan meningkatnya tekanan darah ≥ 140/90 mmHg. Dukungan keluarga adalah suatu bentuk perilaku melayani yang dilakukan oleh keluarga baik dalam bentuk dukungan emosional, penghargaan/penilaian, informasional dan instrumental kepada keluarga saat sehat maupun sakit. Tujuan penelitian ini untuk Menganalisis Hubungan Dukungan Keluarga Dengan Derajat Hipertensi Pada Pasien Hipertensi Di Puskesmas Ranomuut Kota Manado. Metode penelitian yang digunakan yaitu deskriptif analitik dengan rancangan cross sectional. Teknik pengambilan sampel pada penelitian ini yaitu purposive sampling dengan jumlah 68 sampel. Pengumpulan data dilakukan dengan menggunakan kuesioner. Pengolahan data menggunakan program komputer dengan uji spearman dengan tingkat kemaknaan 95% (ɑ = 0,05). Hasil penelitian menunjukkan jumlah responden yang memiliki dukungan keluarga tinggi sebanyak 39 responden (57,4%), dan yang berada pada klasifikasi pre hipertensi sebanyak 37 responden (54,4%) dan yang berada pada klasifikasi hipertensi sebanyak 31 responden (45,6%) dan didapatkan nilai p= 0,000. Kesimpulan ini menunjukkan ada hubungan dukungan keluarga dengan derajat hipertensi. Saran Hasil penilitian ini dapat dikembangkan dengan mencari variabel lain yang diduga mempunyai hubungan dengan derajat hipertensi seperti motivasi, self-care dan lain sebagainya. Kata kunci : Dukungan Keluarga, Hipertensi
High Gamma-Power Predicts Performance in Brain-Computer Interfacing. MPI-IS-TR-003

Subjects operating a brain-computer interface (BCI) based on sensorimotor rhythms exhibit large variations in performance over the course of an experimental session. Here, we show that high-frequency γ-oscillations, originating in fronto-parietal networks, predict such variations on a trial-to-trial basis. We interpret this finding as empirical support for an influence of attentional networks on BCI-performance via modulation of the sensorimotor rhythm. High Gamma-Power Predicts Performance in Brain-Computer Interfacing Moritz Grosse-Wentrup & Bernhard Scholkopf Max Planck Institute for Intelligent Systems, Department Empirical Inference, Spemannstr. 38, 72076 Tubingen, Germany E-mail: moritzgw@ieee.org, bs@tuebingen.mpg. de Abstract. Subjects operating a brain-computer interface (BCI) based on sensorimotor rhythms exhibit large variations in performance over the course of an experimental session. Here, we show that high-frequency γ-oscillations, originating in fronto-parietal networks, predict such variations on a trial-to-trial basis. We interpret this finding as empirical support for an influence of attentional networks on BCI-performance via modulation of the sensorimotor rhythm. Subjects operating a brain-computer interface (BCI) based on sensorimotor rhythms exhibit large variations in performance over the course of an experimental session. Here, we show that high-frequency γ-oscillations, originating in fronto-parietal networks, predict such variations on a trial-to-trial basis. We interpret this finding as empirical support for an influence of attentional networks on BCI-performance via modulation of the sensorimotor rhythm. High γ-Power Predicts BCI-Performance 2
INFRARED PROPERTIES OF A COMPLETE SAMPLE OF STAR-FORMING DWARF GALAXIES

We present a study of a large, statistically complete sample of star-forming dwarf galaxies using mid-infrared observations from the Spitzer Space Telescope. The relationships between metallicity, star formation rate (SFR), and mid-infrared color in these systems show that the galaxies span a wide range of properties. However, the galaxies do show a deficit of 8.0 μm polycyclic aromatic hydrocarbon emission as is apparent from the median 8.0 μm luminosity which is only 0.004 L*8.0 while the median B-band luminosity is 0.05 L*B. Despite many of the galaxies being 8.0 μm deficient, there is about a factor of 4 more extremely red galaxies in the [3.6]−[8.0] color than for a sample of normal galaxies with similar optical colors. We show correlations between the [3.6]−[8.0] color and luminosity, metallicity, and to a lesser extent SFRs that were not evident in the original, smaller sample studied previously. The luminosity–metallicity relation has a flatter slope for dwarf galaxies as has been indicated by previous work. We also show a relationship between the 8.0 μm luminosity and the metallicity of the galaxy which is not expected given the competing effects (stellar mass, stellar population age, and the hardness of the radiation field) that influence the 8.0 μm emission. This larger sample plus a well-defined selection function also allows us to compute the 8.0 μm luminosity function and compare it with the one for the local galaxy population. Our results show that below 109 L☉, nearly all the 8.0 μm luminosity density of the local universe arises from dwarf galaxies that exhibit strong Hα emission—i.e., 8.0 μm and Hα selection identify similar galaxy populations despite the deficit of 8.0 μm emission observed in these dwarfs.
The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus

Kaposi's sarcoma-associated herpesvirus (KSHV) is the aetiological agent of Kaposi's sarcoma (KS), the most frequently arising malignancy in individuals with untreated HIV/AIDS. There are several lines of evidence to indicate that Kaposi's sarcoma oncogenesis is associated with loss of T-cell-mediated control of KSHV-infected cells. KSHV can establish life-long asymptomatic infection in immune-competent individuals. However, when T-cell immune control declines, for example, through AIDS or treatment with immunosuppressive drugs, both the prevalence of KSHV infection and the incidence of KS in KSHV carriers dramatically increase. Moreover, a dramatic and spontaneous improvement in KS is frequently seen when immunity is restored, for example, through antiretroviral therapy or the cessation of iatrogenic drugs. In this paper we describe the current state of knowledge on the T-cell immune responses against KSHV.
Effect of YAP1 silencing on esophageal cancer

Background YAP1, the nuclear effector of the Hippo pathway, has become an attractive target for treatment of malignancies and is a candidate oncogene in esophageal cancer (EC). We hypothesized that knockdown of YAP1 could suppress EC and could be used for targeted therapy. However, there are few reports of the effect of YAP1 knockdown in EC. Materials and methods Quantitative real-time polymerase chain reaction and Western blot assays were performed to determine the expression levels of YAP1 mRNA and protein in primary EC tissue samples, EC cell lines, and controls. Immunohistochemistry was also performed to detect YAP1 protein expression in primary EC tumor and matched nontumor control tissues. YAP1-knockdown cell lines were constructed using short-hairpin RNA, and MTT, flow cytometry, and transwell chamber assays were used to analyze the effect of YAP1 knockdown on EC cell proliferation, apoptosis, and invasion. In vivo tumor formation assays were used to investigate the antitumor effect of YAP1 knockdown. Results We found that YAP1 mRNA and protein were upregulated in EC and that YAP1 expression correlated significantly with metastasis and tumor stage. We also found that YAP1 knockdown repressed cell proliferation and invasion and promoted apoptosis of EC cell lines. In addition, animal experiments revealed that YAP1 knockdown suppressed the growth of esophageal tumors in vivo. Conclusion Collectively, these data confirm our hypothesis that YAP1 knockdown suppresses EC and suggest that YAP1 knockdown could be exploited in the targeted gene therapy of EC in the future.
Throughput Scaling of MIMO Channels With Imperfect CSIT in the Low-SNR Regime

We study the effect of channel estimation error on the performance of water-filling in point-to-point multiple-input- multiple-output (MIMO) channels at low signal-to-noise ratios (SNRs). In this regard, we derive the water-filling throughput of a MIMO channel in the presence of imperfect channel state information at the transmitter (CSIT). The asymptotic growth rate for the throughput, i.e., R, is then found and is compared with the asymptotic growth rate for the capacity with perfect CSIT, i.e., CP, as a function of the signal-to-estimation-error ratio (SER). We show that, at low SNR, for moderate values of the SER, water filling based on erroneous channel estimates can still achieve significant throughputs asymptotically.
On the relationship between azimuthal anisotropy from shear wave splitting and surface wave tomography

[1] Seismic anisotropy provides essential constraints on mantle dynamics and continental evolution. One particular question concerns the depth distribution and coherence of azimuthal anisotropy, which is key for understanding force transmission between the lithosphere and asthenosphere. Here, we reevaluate the degree of coherence between the predicted shear wave splitting derived from tomographic models of azimuthal anisotropy and that from actual observations of splitting. Significant differences between the two types of models have been reported, and such discrepancies may be due to differences in averaging properties or due to approximations used in previous comparisons. We find that elaborate, full waveform methods to estimate splitting from tomography yield generally similar results to the more common, simplified approaches. This validates previous comparisons and structural inversions. However, full waveform methods may be required for regional studies, and they allow exploiting the back-azimuthal variations in splitting that are expected for depth-variable anisotropy. Applying our analysis to a global set ofSKSsplitting measurements and two recent surface wave models of upper-mantle azimuthal anisotropy, we show that the measures of anisotropy inferred from the two types of data are in substantial agreement. Provided that the splitting data is spatially averaged (so as to bring it to the scale of long-wavelength tomographic models and reduce spatial aliasing), observed and tomography-predicted delay times are significantly correlated, and global angular misfits between predicted and actual splits are relatively low. Regional anisotropy complexity notwithstanding, our findings imply that splitting and tomography yield a consistent signal that can be used for geodynamic interpretation.
Prediction of Gut Wall Integrity Loss in Viral Gastroenteritis by Non-Invasive Marker

BACKGROUND: Intestinal fatty acid binding proteins (I-FABPs) are mainly expressed in the intestinal villi, which are the initial site of destruction in viral gastroenteritis. AIM: This study was designed to assess serum I-FABPs as a predictor of gut wall integrity loss in viral gastroenteritis. PATIENTS AND METHODS: This case-control cross-sectional study was conducted on 93 cases of acute viral gastroenteritis. Twenty-eight healthy children matching in age were recruited as control group. Serum I-FABPs were measured using ELISA technique. Viral detection and typing were done by PCR for adenovirus, and by Reverse transcriptase PCR for rotavirus, astrovirus and norovirus. RESULTS: Serum I-FABPs level was significantly higher in the cases compared to the controls and was also higher in the 46 rotavirus gastroenteritis cases compared to other viral gastroenteritis cases. Serum I- FABPs level was significantly higher in severely dehydrated cases as compared to mildly dehydrated ones (P=0.037). CONCLUSION: Serum I-FABPs could be used as an early and sensitive predictor marker of gut wall integrity loss in children with viral gastroenteritis and its level can indicate case severity.
Approximation methods for solutions of system of split equilibrium problems

In this paper, we introduce a new algorithm for finding a common fixed point of a finite family of continuous pseudocontractive mappings which is a unique solution of some variational inequality problem and whose image under some bounded linear operator is a common solution of some system of equilibrium problems in a real Hilbert space. Our result generalize and improve some well-known results.