Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Population Health Status in Six European Countries: Results of a Representative Survey Using the EQ-5D Questionnaire

Background:The EQ-5D questionnaire is an instrument for describing and valuing health states. Objectives:To compare general population health status measured by the EQ-5D in 6 European countries. Methods:In the European Study of the Epidemiology of Mental Disorders representative population samples in Belgium (n = 2411), France (n = 2892), Germany (n = 3552), Italy (n = 4709), the Netherlands (n = 2367), and Spain (n = 5473) completed the EQ-5D as part of personal computer-based home interviews in 2001 to 2003. Results:Of all respondents, 35.1% reported problems in one or more EQ-5D dimensions, most frequently pain/discomfort (28.5%), followed by mobility (13.6%), usual activities (10.5%), anxiety/depression (8.0%), and self-care (3.6%). Proportions of respondents reporting any problems differed significantly between countries, ranging from 26.6% in Spain to 44.5% in France. Mean EQ VAS score was 77.1, ranging from 75.0 in Spain to 82.0 in the Netherlands. After adjusting for sociodemographic variables, the proportion of respondents reporting problems in any of the EQ-5D dimensions was significantly higher in France and lower in Spain and Italy than the grand mean. Even after controlling for reported EQ-5D health states, mean EQ VAS scores were significantly higher in the Netherlands and lower in Spain than the grand mean. Age, female gender, low educational level, lack of paid employment, and low income were associated with more problems in most of the EQ-5D dimensions and lower EQ VAS scores. Conclusions:Self-reported EQ-5D health status differed considerably between countries, calling for caution when making international comparisons of disease burden and health care effectiveness.
A Tale of Two Scales: Evaluating the Relationship Among Life Satisfaction, Social Capital, Income, and the Natural Environment at Individual and Neighborhood Levels in Metropolitan Baltimore

With the rapid growth of cities worldwide, there is a need to better understand factors contributing to life satisfaction in urban environments. Using data from a long-term study of the Baltimore metropolitan region, we build on existing social scientific literature to examine a suite of theoretical factors that have been proposed to explain higher life satisfaction. We find support for many previous theoretical arguments in the literature. Importantly, however, our findings reveal that these results are strikingly scale dependent. For individuals, higher incomes contribute to higher levels of satisfaction, yet social capital does not. For neighborhoods, more social capital strongly increases satisfaction, but higher incomes do not; and access to a clean natural environment always contributes to higher satisfaction, regardless of the scale of analysis. Given these findings, we conclude with the observation that future research must carefully match the “scale” of life satisfaction measurements with the explanatory variables used.
Change of spontaneous reaction of glue and lipiodol mixture during embolization after the addition of tungsten powder: in vitro study.

BACKGROUND AND PURPOSE We have noted that glue-Lipiodol mixtures harden prematurely in the catheter during embolization of brain arteriovenous malformations. However, we observed that hardening of this embolic material does not occur when tungsten powder is added to the glue mixture. In order to clarify the effect of tungsten powder on the glue mixture, we evaluated the reaction time and hardness of the glue mixture in vitro after the addition of tungsten powder. We also measured the pH of the tungsten solution. METHODS Six lots of Lipiodol and three lots of Histoacryl Blue were mixed in a 5-cc bottle with a 50% to 25% glue concentration (glue:Lipiodol = 1:1 to 1:3) and this mixture was observed for 2 weeks. The hardness of the polymerized glue mixture was categorized as liquid, gel, semi-solid, or solid. Various series of experiments were performed after the addition of tungsten powder (0.2 g) and blood (a drop) into the glue mixture. We also separately mixed tungsten and tantalum powder in tubes, each with 5 mL of distilled water, and then measured the pH of these three times. The mixed amounts of tungsten and tantalum ranged from 0.1 to 0.5 mg. RESULTS In a 50% glue concentration, the glue mixture turned into a solid cast within 48 hours. In a 25% concentration, the glue mixture turned into gel within 24 hours. The casts became solid in the 50% and gelled in the 25% concentration, and solid or gel in 28% and 33% glue mixture concentrations. The addition of tungsten powder to 50% and 25% glue mixture concentrations caused the glue mixtures to remain in a liquid state for 2 weeks regardless of the Lipiodol products used. Measurement of acidity achieved using a pH meter in 5 cc of distilled water with tungsten powder (0.1 to 0.5 g) revealed a change of pH from 3.5 to 2.6 according to the amount of tungsten added. Tantalum revealed weak acidity, with a pH range from 6.4 to 5.7. The addition of blood immediately caused the mixture to become solid in 50% and semi-solid in 25% glue concentrations. CONCLUSION The reaction time of the glue mixture differed according to the lot number of the Lipiodol. The addition of tungsten powder appeared to prevent premature cast formation by decreasing the pH with a mechanism similar to that of adding acetic acid.
Eye–hand interactions during goal‐directed pointing movements

SACCADIC eye and hand movements made to step displacements in target position were measured under conditions designed to dissociate the output of the ocular and manual motor systems. This was accomplished by having subjects look and point, either with or without vision of the hand (closed or open loop, respectively) at peripheral targets starting from independent initial positions. The results showed that the amplitude of open loop pointing responses increased in size when accompanied by saccades that were larger than the required hand movement. Providing the subject with visual feedback of the hand during the response or asking them to visually fixate caused this effect to disappear. Taken together, this pattern of results suggests that when vision of the hand is unavailable the programming of saccade metrics influences the control of simultaneously produced pointing movements in an on-line manner.
MEANING IN LATER LIFE: AN ORGANIZING THEME FOR GERONTOLOGICAL CURRICULUM DESIGN

A view of the older person as a meaning making individual is a phenomenological and existential orientation to education and practice in the field of gerontology that provides maximum opportunity for older persons to contribute their life experiences, their individual reality of aging to the theoretical and practical aspects of basic as well as advanced courses in gerontological social work. This article reviews some of the theoretical and empirical formulations of personal meaning in later life, as well as a student experiential and empirical study into the personal meaning dimensions of 198 Israeli younger and older men. The position expressed is that the most important component of gerontology education is the provision of opportunities—structural and contextual—for gaining a better understanding of reality through closer contact with older persons, including but also going beyond the field experience. The need for more humanistic, self‐constructive foundations for curriculum design in gerontology is b.
Unsociable Work? Nonstandard Work Schedules, Family Relationships, and Children’s Well‐Being

Many children live in families where one or both parents work evenings, nights, or weekends. Do these work schedules affect family relationships or well-being? Using cross-sectional survey data from dual-earner Canadian families (N= 4,306) with children aged 2 – 11 years (N= 6,156), we compared families where parents worked standard weekday times with those where parents worked nonstandard schedules. Parents working nonstandard schedules reported worse family functioning, more depressive symptoms, and less effective parenting. Their children were also more likely to have social and emotional difficulties, and these associations were partially mediated through family relationships and parent well-being. For some families, work in the 24-hour economy may strain the well-being of parents and children.
Preliminary Randomized Controlled Trial of Habit Reversal Training for Treatment of Hair Pulling in Youth.

OBJECTIVES This study evaluated the treatment efficacy of habit reversal training (HRT) relative to treatment as usual (TAU) for children and adolescents aged 7-17 years with a primary diagnosis of trichotillomania (TTM). METHOD An initial assessment consisting of semistructured interviews and rating scales was conducted. Participants (N = 40, 85% female) meeting diagnostic criteria for TTM were randomized to either 8 weekly sessions of HRT by trained therapists or 8 weeks of TAU. One week after the final HRT session or final TAU week, patients completed a posttreatment assessment, followed by 1- and 3-month follow-up assessments. All assessments were conducted by a trained rater who was blinded to treatment condition. RESULTS The group by time analysis of variance yielded a significant interaction on the National Institute of Mental Health-Trichotillomania Severity Scale Total Score (F1,38 = 16.47, p < 0.001, η2p = 0.30). The mean score decreased from 12.67 ± 4.60 at baseline to 5.62 ± 4.38 at posttreatment in the HRT group (t20 = 5.99, p < 0.001, d = 1.31), whereas the TAU group changed from 10.42 ± 4.35 to 9.32 ± 4.11 (t18 = 1.34, p = 0.20, d = 0.31). The Massachusetts General Hospital-Hair Pulling Scale Total Score decreased from 15.14 ± 3.86 at baseline to 7.14 ± 5.54 at posttreatment in the HRT group (t20 = 6.16, p < 0.001, d = 1.34); the TAU group changed from 14.16 ± 4.51 to 12.26 ± 4.34 (t18 = 1.50, p = 0.15, d = 0.34). On the Clinical Global Impressions-Improvement, 16/21 participants (76%) were rated as treatment responders in the HRT group versus 4/19 (21%) in the TAU group (χ2 = 12.13, p < 0.001, V = 0.55). At 1-month follow-up, 10-12 treatment responders who completed the assessment maintained improvement. At 3-month follow-up, six of eight maintained improvement. CONCLUSIONS HRT can be an effective treatment for TTM in youth.
Predictors of future fight-related injury among adolescents.

OBJECTIVE Nonfatal fight-related injuries among youths result in lost capacity and high costs of medical care and rehabilitation and constitute a major public health problem. This study identifies factors that predict the occurrence of a fight-related injury that requires medical attention among boys and girls. METHODS We analyzed data from 14 787 adolescents who completing 2 interviews, approximately 1 year apart, in the National Longitudinal Study of Adolescent Health, a nationally representative, school-based sample of youths. We identified time 1 factors at the community, family, and individual levels that predicted any self-reported fight-related injury that required medical treatment at time 2. RESULTS Factors that predict future injury among both boys and girls in multivariate models were violence-related factors: witnessing or being a victim of violence (odds ratio [OR]: 3.69; 95% confidence interval [CI]: 1.81-7.49 for boys; OR: 5.13; 95% CI: 1.25-21.09 for girls), history of a violence-related injury (OR: 2.30; 95% CI: 1.60-3.29 for boys; OR: 3.18; 95% CI: 1.87-5.41 for girls), and physical fighting (OR: 2.02; 95% CI: 1.44-2.84 for boys; OR: 5.15; 95% CI: 3.18-8.34 for girls). Among boys, illicit drug use was also an independent predictor of future injury (OR: 1.72; 95% CI: 1.24-2.37), whereas excellent perceived general health (OR: 0.48; 95% CI: 0.25-0.93) and a high grade point average (OR: 0.52; 95% CI: 0.29-0.95) were significant protective factors against fight-related injury. Girls who reported a high level of depressive symptoms were much more likely to report fight-related injury than nondepressed girls (OR: 8.98; 95% CI: 2.43-33.25). CONCLUSIONS Factors related to violence, substance use, school achievement, and physical and mental health predicted a future fight-related injury that required medical treatment. The results could assist health and social service providers, educators, and others in identifying youths who are at high risk for fight-related injury and may benefit from appropriate intervention.
Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps.

RATIONALE Eosinophilic chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) represents a hard-to-treat subtype of CRS. OBJECTIVES To determine the pattern of expression and biologic role of microRNAs (miRNAs) in CRS, particularly in eosinophilic CRSwNP. METHODS Global miRNA expression in sinonasal mucosa from controls, CRS without nasal polyps (CRSsNP), and patients with eosinophilic CRSwNP was compared using miRNA microarrays. MiR-125b expression was detected by means of quantitative reverse-transcriptase polymerase chain reaction. The cellular localization of miR-125b was determined by in situ hybridization. MiR-125b functional assays were performed on airway epithelial cells and mice. MiR-125b expression regulation was studied by tissue and cell culture. MEASUREMENTS AND MAIN RESULTS CRSsNP and eosinophilic CRSwNP exhibited distinct miRNA expression profiles. MiR-125b was specifically up-regulated in eosinophilic CRSwNP. MiR-125b was mainly expressed by sinonasal and bronchial epithelial cells. EIF4E-binding protein 1 (4E-BP1) was identified as a direct target of miR-125b. MiR-125b mimic or inhibitor enhanced or decreased IFN-α/β production elicited by dsRNA in vitro or in vivo, respectively. 4E-BP1 expression was decreased, whereas IFN regulatory factor-7 and IFN-β expression was increased, in eosinophilic CRSwNP. IFN-β mRNA levels positively correlated with IL-5 mRNA levels and eosinophil infiltration in sinonasal mucosa. IFN-β stimulated B cell-activating factor of the tumor necrosis factor family production in airway epithelial cells. miR-125b could be induced by lipopolysaccharide, dsRNA, and IL-10. CONCLUSIONS The up-regulated expression of miR-125b may enhance type I IFN expression through suppressing 4E-BP1 protein expression in airway epithelial cells, which potentially contributes to mucosal eosinophilia in eosinophilic CRSwNP.
Distribution, Characterization and Genetic Bases of Erythromycin Resistance in Staphylococci and Enterococci Originating from Livestock

The occurrence of staphylococci and enterococci expressing increased resistance to erythromycin (ERY) and, in particular, to macrolide–lincosamide–streptogramin B (MLSB) antibiotics was investigated in dairy cattle, pigs and turkeys. Three hundred rectal (cloacal) swabs of each animal species were examined. A total of 120 and 71 staphylococci and enterococci, respectively, with increased resistance to ERY were identified. These were most frequent in turkeys (42.3% of positive animals), followed by pigs and dairy cattle (6.7% and 6.0% of positive animals, respectively). Similarly, MLSB‐resistant isolates colonized predominantly turkeys (29.7% of animals), while their occurrence in pigs and dairy cattle was only sporadic (0.8% of animals). At least one of the erm genes encoding for MLSB resistance was found in 56.7% and 69.0% of staphylococci and enterococci, respectively. The erm(C) gene prevailed in staphylococci while the erm(B) gene was predominant in enterococci. Macrolide efflux genes msr(A) and msr(C) were also frequent in staphylococci and enterococci, respectively. Macrolide inactivation gene mph(C) occurred mainly in staphylococci. In staphylococci, methicillin resistance was rarely detected (7.5% of isolates), but resistance to telithromycin (ketolides) was frequent in both staphylococci and enterococci (89.2% and 47.9% of isolates, respectively). This study showed that turkeys represent an important source of ERY (MLSB)‐resistant cocci. In addition, resistance to ketolides was also frequent.
THE CHARACTERISTICS OF THE MEMBRANE TRANSPORT OF AMETHOPTERIN AND THE NATURALLY OCCURRING FOLATES

The translocation of amethopterin (MTX) * across the tumor cell membrane plays an important role in determining the cytotoxic effectiveness of this agent. ’ This has provided a stimulus for the investigation of the transport properties of the folate analogues in malignant This report describes studies from this laboratory which characterize a number of aspects of MTX transport in L12 I0 leukemia cells, Ehrlich ascites tumor cells, and rabbit erythrocytes. Other studies are presented which relate these findings to the transport characteristics of the naturally occurring folatcs.
Public Sense of Justice and Judicial Practice

Data on the punitive demands by the public are based on a two-stage random sample drawn from the universe of persons of 18 years or older registered in Finland. The interviews were conducted in January and February, 1964. The percentage of response was 72 (N2 023). The final sample proved to be reasonably representative from a demographic point of view, when the distribution of age, sex, marital status and domicile were compared with those of the population. The data collection and representative quality of the sample have been examined in greater detail elsewhere. ’)
A peptide molecule mimicking the copper(II) transport site of human serum albumin. A comparative study between the synthetic site and albumin.

Abstract Diglycyl-l-histidine is a peptide molecule designed to mimic the specific Cu(II) transport site of human albumin. The equilibria involved in the Cu(II)-diglycyl-l-histidine system have been investigated by analytical potentiometry in aqueous solution (0.15 m NaCl, 25°). The synthetic peptide molecule bound Cu(II) exclusively as a 1:1 complex in the pH range of 6.50 to 11.00. The results further showed that the complex has the same ligand atoms binding to Cu(II) as those suggested for the specific Cu(II) binding site of human albumin. The interaction of peptide with Cu(II) in the presence of albumin, studied by equilibrium dialysis at pH 7.53 and ionic strength 0.16, indicates that this tripeptide is able to compete with albumin for Cu(II). The dissociation constant of the Cu(II)-peptide complex has a value of 1.18 x 10-16 as compared with 6.61 x 10-17 for Cu(II)-albumin. The lower Cu(II) binding strength of the peptide may reflect the influence of either the COOH-terminal free carboxyl group of the peptide or the side chain residues of the Cu(II) binding site in the native protein or both. In the presence of equimolar concentrations of albumin and peptide, and approximately 20-fold excess of l-histidine, there is about 18% of Cu(II) present in the forms of Cu(II)-albumin and l-histidine-Cu(II)-albumin, 36% in the forms of Cu(II)-peptide and l-histidine-Cu(II)-peptide, and 46% as Cu(II)-l-histidine2. The biomedical implications of designing a small molecule to mimic certain functions of a biologically important macromolecule are discussed.
Product involvement in the link between skepticism toward advertising and its effects

Each year businesses spend millions of dollars on advertising to engender a positive attitude among consumers about a specific brand, eliminate any mistrust and suspicion about advertising, and rectify wrong attributions about products. In this research we focused on how doubt about advertisements impacts on their effectiveness, in regard to brand attitude and purchasing intention. We adopted the seemingly unrelated regression model to estimate the parameter, and the mutual relationships among several regression equations are taken into consideration. There were 337 participants in this experiment, and as indicated by the result,doubt about advertisements had a negative effect on brand attitude and purchasing intention.This negative effect will disrupt product involvement.
Normative and Substantive Expertise in Multiple Hypotheses Evaluation

Abstract We distinguish two criteria for evaluating the judgments of trained professionals. One criterion is conformance with a theoretical model and the other is conformance with known external criteria. Further, we label judgments that depart from a theoretical model as errors and those that depart from known external criteria as mistakes. Following this distinction, we hypothesize that auditors′ multiple hypotheses judgments will be characterized by errors but not mistakes. This hypothesis was tested by asking professional auditors to evaluate multiple hypotheses. The results confirm our expectations. Auditors′ judgments reflected ecological base rate information, and they appropriately ignored nondiagnostic evidence. Moreover, auditors did not exhibit a perseverance bias and 84% of them identified the correct hypothesis. The absence of mistakes reflect substantive expertise. Conversely, auditors′ probabilities were not additive, and, when a hypothesis was eliminated, they did not adjust beliefs for the remaining hypotheses. These errors reflect a lack of normative expertise. A second study employed inexperienced subjects to establish whether the strong substantive performance of the professional auditors was attributed to their expertise or was an artifact of the task. The results from the second study were strongly supportive of the substantive expertise explanation. Taken together, these results suggest that substantive expertise can help contain mistakes but it is not sufficient to mitigate errors. Further, lack of normative expertise can lead to errors but these errors do not translate into mistakes. The paper concludes that the distinction between normative and substantive expertise on one hand and errors and mistakes on the other is crucial to understanding when basic findings will generalize to professional settings.
Neutrophilic Fe-Oxidizing Bacteria Are Abundant at the Loihi Seamount Hydrothermal Vents and Play a Major Role in Fe Oxide Deposition

ABSTRACT A number of hydrothermal vent sites exist on the summit of the Loihi Seamount, a shield volcano that is part of the Hawaiian archipelago. The vents are 1,100 to 1,325 m below the surface and range in temperature from slightly above ambient (10°C) to high temperature (167°C). The vent fluid is characterized by high concentrations of CO2 (up to 17 mM) and Fe(II) (up to 268 μM), but there is a general paucity of H2S. Most of the vents are surrounded by microbial mats that have a gelatinous texture and are heavily encrusted with rust-colored Fe oxides. Visually, the Fe oxides appeared homogeneous. However, light microscopy revealed that the oxides had different morphologies, which fell into three classes: (i) sheaths, (ii) twisted or irregular filaments, and (iii) amorphous oxides. A morphological analysis of eight different samples indicated that the amorphous oxides were overall the most abundant; however, five sites had >50% sheaths and filamentous oxides. These latter morphologies are most likely the direct result of microbial deposition. Direct cell counts revealed that all of the oxides had abundant microbial populations associated with them, from 6.9 × 107 to 5.3 × 108 cells per ml of mat material. At most sites, end point dilution series for lithotrophic Fe oxidizers were successful out to dilutions of 10−6 and 10−7. A pure culture was obtained from a 10−7 dilution tube; this strain, JV-1, was an obligate, microaerophilic Fe oxidizer that grew at 25 to 30°C. A non-cultivation-based molecular approach with terminal-restriction fragment length polymorphism also indicated the common presence of Fe-oxidizing bacteria at Loihi. Together, these results indicate that Fe-oxidizing bacteria are common at the Loihi Seamount and probably play a major role in Fe oxidation. A review of the literature suggests that microbially mediated Fe oxidation at hydrothermal vents may be important globally.