Miracle-dz/UniFAR-FTUs huggingface dataset:
Activity of cabozantinib (XL184) in advanced ovarian cancer patients (pts): Results from a phase II randomized discontinuation trial (RDT).

5008 Background: Cabozantinib (Cabo) is an oral, potent inhibitor of MET and VEGFR2. MET over-expression has been observed in advanced ovarian cancer (OC). Anti-VEGF pathway agents have shown clinical benefit in pts w/ OC. Simultaneous targeting of the MET and VEGF signaling pathways with Cabo may therefore be a promising treatment strategy. METHODS Epithelial OC pts with progressive measurable disease (mRECIST) received Cabo at 100 mg qd PO over a 12 wk Lead-in stage. Up to 2 prior regimens are allowed for platinum-resistant (R), and up to 3 prior regimens for platinum-sensitive (S) pts. Tumor response was assessed every 6 wks. Treatment ≥ wk 12 was based on response: pts with PR continued open-label Cabo, pts with SD were randomized to Cabo vs placebo, and pts with PD discontinued. Primary endpoint was ORR per mRECIST in the Lead-in stage, and progression free survival (PFS) in the randomized period. Accrual in any cohort could be halted for either high rates of ORR or PD. RESULTS Accrual was halted at 68 pts based on an observed high rate of clinical activity. The median number of prior systemic treatments was 2. Most common related AEs ≥Grade 3 were hand-foot syndrome (10%), diarrhea (8%) and fatigue (4%). Dose reductions and permanent discontinuations for AEs occurred in 43% and 10% of pts, respectively. Of 51 pts evaluable for mRECIST RR at 12 wks, 28 are R, 17 are S, and 6 have unknown status. mRECIST RR at 12 wks: overall = 12/51(24%), R = 5/28(18%); S= 5/17(29%). Five additional PRs await confirmation. The overall DCR (PR+SD) at wk 12 is 58% (30/51). After a median f/u of 4 mos (range: 1 to 11 mos), the median duration of response and median PFS have not been reached. CA125 responses (assessed by GCIG criteria) in 40 pts with ≥1 post-baseline result: 7/40 (18%). Median maximum increase in hemoglobin (Hb) in anemic pts (Hb < 11 g/dL) was 1.9 g/dL (N=8 in pts w/ ≥ 6 wk f/u; range, 1.1-3.2 g/dL). All maximum Hb changes occurred w/in the first 12 wks. Randomization in this cohort was halted & pts unblinded due to observed efficacy. CONCLUSIONS Cabo exhibits clinical activity in ovarian cancer pts with advanced disease, regardless of prior platinum status, as reflected by high rates of response.
Pattern of Uveitis at a Referral Center in Iraq

Purpose: To determine the etiologies of uveitis and the causes of visual loss in uveitis patients at a referral center in Baghdad, Iraq. Patients and Methods: A 4-year prospective study was performed at the uveitis clinic at Ibn Al-Haetham teaching eye hospital in Baghdad, Iraq. Referral cases of active uveitis were included. A complete ophthalmic examination was performed in all cases. If clinical picture did not indicate a specific etiology, patients were sent for a routine set of tests while ancillary tests were conducted when indicated. Results: Out of 318 patients included in this study, 236 patients (74.2%) had bilateral uveitis, and 212 patients (66.7%) had non-granulomatous uveitis. Posterior uveitis was recorded in 123 cases (38.7%) followed by panuveitis in 97 cases (30.5%), anterior uveitis in 78 cases (24.5%), and intermediate uveitis in 20 cases (6.3%). A diagnosis was established in 210 cases (66%) while etiology could not be determined in the remaining 108 cases (34%). Most common infectious causes were toxoplasmosis (13.8%) and presumed ocular tuberculosis (11.4%) while most common non-infectious causes were Vogt-Koyanagi-Harada disease (12.3%), Behηet's disease (8.2%), and pars planitis (5.7%). Out of 49 eyes with irreversible blindness, macular degenerations, or scars (46.9%) and optic nerve atrophy (34.7%) were the most important causes. Conclusion: At this referral center, toxoplasmosis and presumed ocular tuberculosis were the most common infectious causes of uveitis while Vogt-Koyanagi-Harada disease, Behηet's disease, and pars planitis were, in that order, the most common non-infectious causes. Macular degenerations or scars and optic nerve atrophy were the most important causes of irreversible blindness.
Cash Savings and Stock Price Informativeness

This paper shows that managers use the information they learn from the stock market when they decide on corporate cash savings. In particular, corporate savings are much more sensitive to stock price when the price contains more information that is new to managers. Moreover, the significant effect of stock price informativeness on the savings-to-price sensitivity is not due to market mispricings and remains even after controlling for various sources of public and managerial private information. Overall, the results highlight a new channel through which the stock market affects corporate decisions, which suggests that the stock market is not a sideshow. Copyright 2012, Oxford University Press.
Vasopressin and its analog terlipressin versus norepinephrine in the treatment of septic shock : a meta-analysis

Purpose: To compare the effectiveness and safety of vasopressin and its analog terlipressin with norepinephrine treatment in adult patients with septic shock and to explore the most effective and safe protocol. Materials and Methods: This study was based on Cochrane methodology for conducting meta-analysis. Only randomized controlled trials were eligible for this study. The participants were adults who had septic shock. The Review Manager Database (RevMan version 5.1, The Cochrane Collaboration 2011) was used to analyze selected studies. Results: Eleven randomized controlled trial involving 2273 patients were included. The mortality rate was significantly lower in the vasopressin/terlipressin group (relative risk 0.87). The pulmonary artery occlusion pressure was higher in the vasopressin/terlipressin group (mean difference 1.51, 95% CI 0.84 to 2.17). Subgroup analysis showed the mortality rate, heart rate and cardiac index were significantly lower in the vasopressin group compared with the norepinephrine group. Conclusions: Compared with norepinephrine, vasopressin and its analog terlipressin could significantly reduce mortality rate of adult septic shock patients. The combination of low-dose vasopressin and corticosteroids was associated with decreased mortality, heart rate and cardiac index compared with conjoint use of norepinephrine and corticosteroids.
Cell free DNA detected by a novel method in acute ST-elevation myocardial infarction patients

Abstract Background: High levels of circulating cell free DNA (CFD) have been associated with poor prognosis in various diseases. Data pertaining to CFD in acute myocardial infarction (MI) are scarce. The available data have been obtained by either electrophoresis or polymerase chain reaction. We evaluated a novel method for the detection of CFD in patients with ST elevation myocardial infarction (STEMI) and examined its correlation with established markers of necrosis and ventricular function. Methods: Serum concentrations of CFD, troponin-T and creatine kinase (CK) were measured simultaneously in 16 randomly selected acute STEMI patients upon admission and at three more time points. 47 healthy subjects served as a control group. CFD was quantified by a novel rapid fluorometric assay. Ejection fraction (EF) was assessed by echocardiography. Results: Peak CFD levels were significantly higher in patients compared with controls (P = 0.001) and correlated with peak levels of CK and troponin-T (R = 0.79, P <0.001); R = 0.65, P = 0.006, respectively). Peak CFD levels tended to be associated with lower EF (P = 0.075). Conclusion: With this method, CFD levels correlated with the levels of established markers of myocardial necrosis but not with EF. The kinetic pattern of CFD release after STEMI and its prognostic value require further investigation.
Interpretation of Inhalation Airflow Measurements for Respirator Design and Testing

ecent studies and much debate have focused on quantifying the airflow requirements of respirator users, particularly under conditions of very high to maximal work rates. It is often assumed that respirators and their components must be tested at flow rates that closely match these measurements to assure protection to users. This overly simplified assumption ignores the differences between laboratory tests and the workplace conditions in which respirators are used. While respirators and their components could be designed to comply with any airflow requirement, any change in performance requirements must first be evaluated to ensure it does not decrease workplace performance or user comfort. This paper suggests appropriate use of airflow measurements in setting respirator performance criteria and evaluating user protection. Available data do not suggest a need for change in testing criteria at this time. There is no indication that respirators that meet current U.S. approval criteria or substantially similar tests need performance enhancement to provide acceptable protection.
Similarity and Specialization of the Larval versus Adult Diet of European Butterflies and Moths

Many herbivorous insects feed on plant tissues as larvae but use other resources as adults. Adult nectar feeding is an important component of the diet of many adult herbivores, but few studies have compared adult and larval feeding for broad groups of insects. We compiled a data set of larval host use and adult nectar sources for 995 butterfly and moth species (Lepidoptera) in central Europe. Using a phylogenetic generalized least squares approach, we found that those Lepidoptera that fed on a wide range of plant species as larvae were also nectar feeding on a wide range of plant species as adults. Lepidoptera that lack functional mouthparts as adults used more plant species as larval hosts, on average, than did Lepidoptera with adult mouthparts. We found that 54% of Lepidoptera include their larval host as a nectar source. By creating null models that described the similarity between larval and adult nectar sources, we furthermore showed that Lepidoptera nectar feed on their larval host more than would be expected if they fed at random on available nectar sources. Despite nutritional differences between plant tissue and nectar, we show that there are similarities between adult and larval feeding in Lepidoptera. This suggests that either behavioral or digestive constraints are retained throughout the life cycle of holometabolous herbivores, which affects host breadth and identity.
Legal versus non-legal approaches to forensic science evidence

In their attempts to determine the admissibility and probative value of forensic science and medicine evidence, common law courts have tended to focus on considerations such as: the formal qualifications and training of the analyst, the analyst’s experience doing the same or similar things, the existence of a field, whether the evidence might assist the jury, apparent partisanship and plausibility, the overall strength of the case and even the perceived need to accommodate technological innovation. This article reviews conventional English approaches to the admission and evaluation of expert evidence. It aims to contrast legal approaches to forensic science evidence with the kinds of criteria being promoted by a range of peak scientific organisations. This comparative exercise suggests that admissibility jurisprudence and legal practice might be misguided, particularly in their attempts to regulate the comparison or pattern matching disciplines. The article will suggest that courts have privileged the wrong kinds of heuristics in their attempts to engage with scientific and technical forms of knowledge. More disturbingly, it questions whether conventional admissibility standards, even in conjunction with trial safeguards, provide jurors and judges with the kinds of information required to rationally assess much of the incriminating expert opinion evidence routinely presented in criminal proceedings.
Connections of the cerebral cortex. I. The albino rat. A. Topography of the cortical areas

CONTENTS Introduction Frontal region Parietal region Temporal region Occipital region Insular region and rhinal sulcus Cingular region Pyriform region R2ti-c hippocampal region (Areas 10, 6, 4, 8, 8a, 11.) (Areas 2, 3, 1, 7, 40, 39.) (Areas 41, 20, 36.) (Areas 17, 18, 18a.) (Area 14.) (breas 24, 32, 23, 29b, 29c.) (Area 51.) . 222 . 224 228 . 232 . 2.14 . 236 . 236 . 238 . 239 (Areas 35, 283, ? 8b, 49, 2ia, 27b, suhiculum.) Discussion 242 A. Comparison with pievious studies 512 €3. Development of plan of cortical areas 252 Plates 1-8 m 2 7 5 Literature cited 258
Collective impact facilitators: how contextual and procedural factors influence collaboration

Abstract Collective impact (CI) has primarily been applied to solving organic adaptive problems that evolve over time. While this framework aligns broadly with the collaboration literature, the dynamic, and at times forced, nature of this work in practice poses challenges. This study used a quasi-experimental design to test a CI model of the facilitators of mandated collaboration measured by the Levels of Collaboration Scale and the Wilder Collaboration Factors Inventory. Hierarchical linear regression techniques and data from 126 early childhood community stakeholders were used to test the impact of facilitators, including key elements of CI, on perceived collaboration. Findings show that: (1) policy mandates have a significant, positive correlation with collaboration; and (2) the only significant predictor of collaboration is informal relationships. This analysis suggests a hybrid process, combining key elements of CI with a focus on relationship building, to support effective collaboration practice.
Assessment of the Clinical Management of Fragility Fractures and Implications for the New HEDIS Osteoporosis Measure

Background: Rates of screening for and treatment of osteoporosis have been low, even among those with fractures who are at greatest risk for new fractures. Objective: The objective of this study was to examine trends in the clinical management of patients with fragility fractures to provide baseline data for future assessments of the impact of the new Health Plan Employer Data and Information Set (HEDIS) measure. Research Design: The MarketScan Medicare Supplemental and Coordination of Benefits (COB) database was used to examine adherence to the 2004 HEDIS guidelines by measuring the percent of women age 67 and older who were screened and/or treated after a fracture from 2000 through 2005. Clinical, demographic, and provider characteristics were assessed to determine the correlates of being screened and treated. Results: The overall unadjusted percent of women screened and treated remains low, with just 10.2% screened and 12.9% treated in 2005. Multivariate analyses, which controlled for fracture location, patient characteristics, physician specialty, and region indicated small, albeit statistically significant, increases in treatment and screening over time. Women fracturing in 2005 were 27% more likely to be screened and 15% more likely to receive treatment relative to those fracturing in the year 2000. Conclusions: Although our study found some improvements in the screening for and treatment of osteoporosis among Medicare beneficiaries with a fragility fracture from 2000 through 2005, the overall percent of women screened and/or treated remained low. These data provide a baseline for assessing the impact of the new HEDIS measure in the coming years.
Assigned value improves memory of proper names

Names are more difficult to remember than other personal information such as occupations. The current research examined the influence of assigned point value on memory and metamemory judgements for names and occupations to determine whether incentive can improve recall of proper names. In Experiment 1 participants studied face–name and face–occupation pairs assigned 1 or 10 points, made judgements of learning, and were given a cued recall test. High-value names were recalled more often than low-value names. However, recall of occupations was not influenced by value. In Experiment 2 meaningless nonwords were used for both names and occupations. The name difficulty disappeared, and value influenced recall of both names and occupations. Thus value similarly influenced names and occupations when meaningfulness was held constant. In Experiment 3 participants were required to use overt rote rehearsal for all items. Value did not boost recall of high-value names, suggesting that differential processing could not be implemented to improve memory. Thus incentives may improve memory for proper names by motivating people to engage in selective rehearsal and effortful elaborative processing.
The impact of information and communication technology capital on labour productivity : A complete macro economic framework by

This paper aims at measuring the net impact of Information and Communication Technology (ICT). We hold a general definition of ICT capital widely adopted in the literature including computer hardware, software and communication equipment. For numerical application to the French economy we use national accounting data on capital stock and investment. We concentrate on ICT capital accumulation and do not tackle the issue of ICT producing industries, which lies outside the range of this paper. In a first part, focusing on the supply-side of the economy, we take the growth accounting methodology as a starting point. We show that it cannot provide us with a measure of the net economic impact of ICT capital accumulation, since it does not take into account substitution among production factors. We develop an alternative theoretical framework, which enables us to define a counterfactual " non ICT " scenario, that is to say a scenario in which such a development of ICT capital does not appear. This framework relies on the profit optimising behaviour of firms. Therefore the share of ICT capital in total capital stock depends on its relative cost. We use a production function with a constant elasticity of substitution (CES type) between labour and capital. The capital itself is defined as an aggregated good through a second CES production function combining ICT capital and non-ICT capital. Although suffering from strong restrictions on our production process, this simple framework enables us to measure the impact of the shock on the relative cost of ICT capital on labour productivity with substitution effects between production factors. As for the results during the period considered 1995-2000 with the most common parameters value economists agreed on we find that the net impact of ICT capital accumulation would be half the one generally measured when resorting to growth accounting methods. In a second part, we insert this framework in a macro econometric model. We use Mesange, a model of the French economy developed by the Forecasting Directorate (Ministry of the Economy, Finance and Industry) and the INSEE (French National Institute of Statistics). It is a quarterly model with about 500 equations, including 40 econometric ones that reflect economic agents' behavior. It has traditional features : in the short-run output depends on demand, whereas long-run properties are derived from a coherent theoretical description of the supply-side of the economy. We add to this description the effects derived from the …
An Exploration of Gender and Career Stage Differences on a Multidimensional Measure of Work Meaningfulness

In recent years, the constructs of work meaning and work meaningfulness have been differentiated, and multidimensional measures of the latter have been developed. In the present study, we administered one such measure—the Comprehensive Meaningful Work Scale (CMWS)—to a gender-balanced and age-diverse sample of managers and conducted a multivariate analysis of CMWS scores that explored the contributions of participants’ gender and their adult career stage. As hypothesized, the CMWS subscale scores were negatively correlated with participants’ scores on an independent measure of work stress. Results also revealed a significant multivariate effect associated with their career stage that was limited to one CMWS subscale (i.e., “balancing tensions”), with managers in their “prime work years” (i.e., 40–54) evidencing less favorable scores than those in either the “settling in” (i.e., 25–39) or “approaching retirement” (i.e., 55–65) stages. The implications of these findings for future research on work meaningfulness are discussed.
Treating Tics and Tourette’s Disorder in School Settings

Children with Tourette’s Disorder (TD) and other forms of tic disorders display a range of academic and psychosocial impairments that place them at risk for experiencing long-term negative life outcomes. Fortunately, effective treatments and interventions such as habit reversal training (HRT) have been developed and implemented in clinical settings to help these children. However, relatively few youth with tics and related sequelae receive effective treatments for their symptoms, often because of various treatment barriers (e.g., travel difficulties, limitations in trained practitioners). To overcome some of these barriers, educators and school-based mental health practitioners can provide a range of academic, social-emotional, and mental health supports to address the needs of youth with tics in school settings. In support of this notion, this article discusses various ways that members of school communities can help support the academic and social-emotional success of students with tics and related impairments.
Schizophrenia in British Afro-Caribbeans: Two Debates Confused?

The concept and aetiology of schizophrenia remain controversial issues. Epidemi ological studies reveal considerable variations in rates of diagnosed cases between groups. British Afro-Caribbeans show high rates. At the same time, their psychiatric experience is marked by a high level of conflict with the psychiatric services. The two debates - that surrounding the concept of schizophrenia, and that concerning the psychiatric experiences of British Afro-Caribbeans - need to be separated so that each receives appropriate consideration. Studies based on the experiences of people diagnosed as schizophrenic may confuse rather than advance the first debate if due care is not paid to the reliability of the diagnosis. The second debate has consequences for the development of psychiatric services. Further unad dressed questions referring to the mental health of ethnic minorities are suggested.
Video Game Acceptance: A Meta-Analysis of the Extended Technology Acceptance Model

The current study systematically reviews and summarizes the existing literature of game acceptance, identifies the core determinants, and evaluates the strength of the relationships in the extended technology acceptance model. Moreover, this study segments video games into two categories: hedonic and utilitarian and examines player acceptance of these two types separately. Through a meta-analysis of 50 articles, we find that perceived ease of use (PEOU), perceived usefulness (PU), and perceived enjoyment (PE) significantly associate with attitude and behavioral intention. PE is the dominant predictor of hedonic game acceptance, while PEOU and PU are the main determinants of utilitarian game acceptance. Furthermore, we find that respondent type and game platform are significant moderators. Findings of this study provide critical insights into the phenomenon of game acceptance and suggest directions for future research.