Miracle-dz/UniFAR-FTUs huggingface dataset:
Rheumatoid arthritis patients' education - contents and methods.

AIMS AND OBJECTIVES The purpose of this study is to describe the contents and methods used by rheumatology nurses when they educate their patients with rheumatoid arthritis. BACKGROUND Rheumatology nurses have an important role in educating patients with rheumatoid arthritis. However, there is a lack of knowledge on the content provided and the methods used by rheumatology nurses. DESIGN AND METHODS The sample was drawn in using stratified random sampling and the data were collected from 80 rheumatology nurses with a questionnaire in 2003-2004 (response rate was 65.2%). The data were analysed using descriptive and non-parametric statistical tests. RESULTS Medical treatment was the most commonly taught issue, as 76% of rheumatology nurses gave information on anti-rheumatic drugs prescribed to the rheumatoid arthritis patients and blood tests (64%) which must be taken as follow-up controls. Only 45% of the nurses discussed self care at home. Individual oral patient education (88%) and written materials by the local hospitals or drug industries (71%), were the most commonly used methods. Patients with rheumatoid arthritis were educated mostly in special health care units. A rheumatology nursing course did not have an effect on the chosen contents or methods when educating rheumatoid arthritis patients. CONCLUSIONS It is important that rheumatology nurses teach more self-care abilities to patients with rheumatoid arthritis and use also the other teaching methods than oral individual method such as group sessions, teleinformatics and internet. The contents of rheumatology nursing course should be developed further to stress the importance of appropriate teaching methods and to point out the importance of self care abilities for patients. RELEVANCE TO CLINICAL PRACTICE The results provided useful insight into education of patients with rheumatoid arthritis. Nurses should avoid the routine teaching programmes. They should take time to discuss with their patients and plan together the contents and methods, that education of patients with rheumatoid arthritis is based on patients' information needs and their individual learning capabilities.
Overweight children have a greater proportion of fat mass relative to muscle mass in the upper limbs than in the lower limbs: implications for bone strength at the distal forearm.

BACKGROUND The influence of adiposity on upper-limb bone strength has rarely been studied in children, despite the high incidence of forearm fractures in this population. OBJECTIVE The objective was to compare the influence of muscle and fat tissues on bone strength between the upper and lower limbs in prepubertal children. DESIGN Bone mineral content, total bone cross-sectional area, cortical bone area (CoA), cortical thickness (CoTh) at the radius and tibia (4% and 66%, respectively), trabecular density (TrD), bone strength index (4% sites), cortical density (CoD), stress-strain index, and muscle and fat areas (66% sites) were measured by using peripheral quantitative computed tomography in 427 children (206 boys) aged 7-10 y. RESULTS Overweight children (n = 93) had greater values for bone variables (0.3-1.3 SD; P < 0.0001) than did their normal-weight peers, except for CoD 66% and CoTh 4%. The between-group differences were 21-87% greater at the tibia than at the radius. After adjustment for muscle cross-sectional area, TrD 4%, bone mineral content, CoA, and CoTh 66% at the tibia remained greater in overweight children, whereas at the distal radius total bone cross-sectional area and CoTh were smaller in overweight children (P < 0.05). Overweight children had a greater fat-muscle ratio than did normal-weight children, particularly in the forearm (92 +/- 28% compared with 57 +/- 17%). Fat-muscle ratio correlated negatively with all bone variables, except for TrD and CoD, after adjustment for body weight (r = -0.17 to -0.54; P < 0.0001). CONCLUSIONS Overweight children had stronger bones than did their normal-weight peers, largely because of greater muscle size. However, the overweight children had a high proportion of fat relative to muscle in the forearm, which is associated with reduced bone strength.
Electric field-oriented growth of carbon nanotubes and Y-branches in a needle-pulsed arc discharge unit: mechanism of the production

Carbon nano-onions, multiwall carbon nanotubes and Y-branched nanotubes are synthesised in a simple production apparatus. A pulsed plasma is generated by discharging a high voltage needle pulse between two graphite electrodes. A strong electric field is presented along anode and cathode electrodes. The pulse width is 0.3 μs. Acetone vapour, as a precursor, is introduced to the plasma through a graphite nozzle in the cathode assembly. A magnetic field, perpendicular to the plasma path, is provided. The possibility of carbon nanotube production through a short-pulsed arc discharge technique is investigated in this article. The results show that adding an electric field between electrodes prevents carbon ions’ dispersion, facilitates charge transferring between ions and electrodes, orients the growth of carbon nanotubes along the applied electric field and finally makes it possible to produce functionalised carbon nanoparticles such as Y-branch nanotubes and nanoknees. In this work, the growth mechanism of carbon nanotubes in a needle-pulsed arc-discharge reactor is discussed. And a possible explanation is provided for the synthesis of Y-branch carbon nanotubes. The products are examined by using scanning probe microscopy technique.
ATM-based transport architecture for multiservices wireless personal communication networks

This paper presents an ATM-based transport architecture for next-generation multiservices personal communication networks (PCN). Such "multimedia capable" integrated services wireless networks are motivated by an anticipated demand for wireless extensions to future broadband networks. An ATM compatible wireless network concept capable of supporting a mix of broadband ISDN services including constant bit-rate (CBR), variable bit-rate (VBR), and packet data transport is explored from an architectural viewpoint. The proposed system uses a hierarchical ATM switching network for interconnection of PCN microcells, each of which is serviced by high-speed, shared-access radio links based on ATM-compatible cell, relay principles. Design issues related to the physical (modulation), media access control (MAC), and data-link layers of the ATM-based radio link are discussed, and preliminary technical approaches are identified in each case. An example multiservice dynamic reservation (MDR) TDMA media access protocol is then considered in further detail, and simulation results are presented for an example voice/data scenario with a proportion of time-critical (i.e., multimedia) packet data. Time-of-expiry (TOE) based queue service disciplines are also investigated as a mechanism for improving the quality-of-service (QoS) in this scenario. >
Classification of stop consonant place of articulation

One of the approaches to automatic speech recognition is a distinctive feature-based speech recognition system, in which each of the underlying word segments is represented with a set of distinctive features. This thesis presents a study concerning acoustic attributes used for identifying the place of articulation features for stop consonant segments. The acoustic attributes are selected so that they capture the information relevant to place identification, including amplitude and energy of release bursts, formant movements of adjacent vowels, spectra of noises after the releases, and some temporal cues. An experimental procedure for examining the relative importance of these acoustic attributes for identifying stop place is developed. The ability of each attribute to separate the three places is evaluated by the classification error based on the distributions of its values for the three places, and another quantifier based on F-ratio. These two quantifiers generally agree and show how well each individual attribute separates the three places. Combinations of non-redundant attributes are used for the place classifications based on Mahalanobis distance. When stops contain release bursts, the classification accuracies are better than 90%. It was also shown that voicing and vowel frontness contexts lead to a better classification accuracy of stops in some contexts. When stops are located between two vowels, information on the formant structures in the vowels on both sides can be combined. Such combination yielded the best classification accuracy of 95.5%. By using appropriate methods for stops in different contexts, an overall classification accuracy of 92.1% is achieved. Linear discriminant function analysis is used to address the relative importance of these attributes when combinations are used. Their discriminating abilities and the ranking of their relative importance to the classifications in different vowel and voicing contexts are reported. The overall findings are that attributes relating to the burst spectrum in relation to the vowel contribute most effectively, while attributes relating to formant transition are somewhat less effective. The approach used in this study can be applied to different classes of sounds, as well as stops in different noise environments. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)
Association between tooth loss and dementia among older people: a meta‐analysis

A part of this work was supported by ‘Japan Advanced Molecular Imaging Program (J-AMP)’, and grant-inaid for Young Scientists (B) (22790836) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, a grant-in-aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and a grant-in-aid for Comprehensive Research on Dementia (no. 22790836) from the Ministry of Health, Labour and Welfare.
The Influence of Injection Molding and Injection Compression Molding on Ultra-high Molecular Weight Polyethylene Polymer Microfabrication

Abstract The replication accuracy of ultra-high molecular weight polyethylene (UHMWPE) was investigated by using injection molding (IM) and injection compression molding (ICM). The mold insert was fabricated by using a stainless-steel etching method. Both the injection molded part and the injection compression molded part were observed under a microscope to compare the quality and accuracy of the replication. A high performance surface profiler was used to measure the microstructure profile. For the mold insert, the injection molded parts and injection compression molded parts were measured. The experimental results show that the UHMWPE can fill in microcavities by using IM and ICM technology. The height and shape of microstructure were influenced by the IM process parameters. For an injection molded part, the injection velocity was the most significant factor. This study also revealed that the ICM method was a more stable microstructure processing method than that of the IM. However, for better replication accuracy, both the IM and ICM processes require parametric optimization.
Model checking of software for microcontrollers

The interest of industries in model checking software for microcontrollers is increasing. However, there are currently no appropriate tools that can be applied by embedded systems developers for the direct verification of software for microcontrollers without the need for manual modeling. This article describes a new approach to model checking software for microcontrollers, which verifies the assembly code of the software. The state space is built using a tailored simulator, which abstracts from time, handles nondeterminism, and creates an overapproximation of the behavior shown by the real microcontroller. Within this simulator, we apply abstraction techniques to tackle the state-explosion problem. In our approach, we combine different formal methods, namely, model checking, static analysis, and abstract interpretation. We also combine explicit and symbolic model checking techniques. This article presents a case study using several programs to demonstrate the efficiency of the applied abstraction techniques and to show the applicability of this approach.
Self-optimizing control of a large-scale plant: The Tennessee Eastman process

The paper addresses the selection of controlled variables, that is, “what should we control”. The concept of self-optimizing control provides a systematic tool for this, and in the paper we show how it may be applied to the Tennessee Eastman process which has a very large number of candidate variables. In the paper we present a systematic procedure for reducing the number of alternatives. One step is to eliminate variables which with constant setpoints result in large losses or infeasibility when there are disturrbances (with the remaining degrees of freedom reoptimized).
Microsatellite Tandem Repeats Are Abundant in Human Promoters and Are Associated with Regulatory Elements

Tandem repeats are genomic elements that are prone to changes in repeat number and are thus often polymorphic. These sequences are found at a high density at the start of human genes, in the gene’s promoter. Increasing empirical evidence suggests that length variation in these tandem repeats can affect gene regulation. One class of tandem repeats, known as microsatellites, rapidly alter in repeat number. Some of the genetic variation induced by microsatellites is known to result in phenotypic variation. Recently, our group developed a novel method for measuring the evolutionary conservation of microsatellites, and with it we discovered that human microsatellites near transcription start sites are often highly conserved. In this study, we examined the properties of microsatellites found in promoters. We found a high density of microsatellites at the start of genes. We showed that microsatellites are statistically associated with promoters using a wavelet analysis, which allowed us to test for associations on multiple scales and to control for other promoter related elements. Because promoter microsatellites tend to be G/C rich, we hypothesized that G/C rich regulatory elements may drive the association between microsatellites and promoters. Our results indicate that CpG islands, G-quadruplexes (G4) and untranslated regulatory regions have highly significant associations with microsatellites, but controlling for these elements in the analysis does not remove the association between microsatellites and promoters. Due to their intrinsic lability and their overlap with predicted functional elements, these results suggest that many promoter microsatellites have the potential to affect human phenotypes by generating mutations in regulatory elements, which may ultimately result in disease. We discuss the potential functions of human promoter microsatellites in this context.
A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese

Systemic lupus erythematosus (SLE) is an autoimmune disease that causes multiple organ damage. Although recent genome-wide association studies (GWAS) have contributed to discovery of SLE susceptibility genes, few studies has been performed in Asian populations. Here, we report a GWAS for SLE examining 891 SLE cases and 3,384 controls and multi-stage replication studies examining 1,387 SLE cases and 28,564 controls in Japanese subjects. Considering that expression quantitative trait loci (eQTLs) have been implicated in genetic risks for autoimmune diseases, we integrated an eQTL study into the results of the GWAS. We observed enrichments of cis-eQTL positive loci among the known SLE susceptibility loci (30.8%) compared to the genome-wide SNPs (6.9%). In addition, we identified a novel association of a variant in the AF4/FMR2 family, member 1 (AFF1) gene at 4q21 with SLE susceptibility (rs340630; P = 8.3×10−9, odds ratio = 1.21). The risk A allele of rs340630 demonstrated a cis-eQTL effect on the AFF1 transcript with enhanced expression levels (P<0.05). As AFF1 transcripts were prominently expressed in CD4+ and CD19+ peripheral blood lymphocytes, up-regulation of AFF1 may cause the abnormality in these lymphocytes, leading to disease onset.
Complementary but Distinct Roles for MRI and 18F-Fluoromisonidazole PET in the Assessment of Human Glioblastomas

Glioblastoma multiforme is a primary brain tumor known for its rapid proliferation, diffuse invasion, and prominent neovasculature and necrosis. This study explores the in vivo link between these characteristics and hypoxia by comparing the relative spatial geometry of developing vasculature inferred from gadolinium-enhanced T1-weighted MRI (T1Gd), edematous tumor extent revealed on T2-weighted MRI (T2), and hypoxia assessed by 18F-fluoromisonidazole PET (18F-FMISO). Given the role of hypoxia in upregulating angiogenic factors, we hypothesized that the distribution of hypoxia seen on 18F-FMISO is correlated spatially and quantitatively with the amount of leaky neovasculature seen on T1Gd. Methods: A total of 24 patients with glioblastoma underwent T1Gd, T2, and 18F-FMISO—11 studies preceded surgical resection or biopsy, 7 followed surgery and preceded radiation therapy, and 11 followed radiation therapy. Abnormal regions seen on the MRI scan were segmented, including the necrotic center (T0), the region of abnormal blood–brain barrier associated with disrupted vasculature (T1Gd), and infiltrating tumor cells and edema (T2). The 18F-FMISO images were scaled to the blood 18F-FMISO activity to create tumor-to-blood ratio (T/B) images. The hypoxic volume (HV) was defined as the region with T/Bs greater than 1.2, and the maximum T/B (T/Bmax) was determined by the voxel with the greatest T/B value. Results: The HV generally occupied a region straddling the outer edge of the T1Gd abnormality and into the T2. A significant correlation between HV and the volume of the T1Gd abnormality that relied on the existence of a large outlier was observed. However, there was consistent correlation between surface areas of all MRI-defined regions and the surface area of the HV. The T/Bmax, typically located within the T1Gd region, was independent of the MRI-defined tumor size. Univariate survival analysis found the most significant predictors of survival to be HV, surface area of HV, surface area of T1Gd, and T/Bmax. Conclusion: Hypoxia may drive the peripheral growth of glioblastomas. This conclusion supports the spatial link between the volumes and surface areas of the hypoxic and MRI regions; the magnitude of hypoxia, T/Bmax, remains independent of size.
Global impacts of energy demand on the freshwater resources of nations

Significance Understanding the role of international trade in driving pressures on freshwater resources is key to meeting challenges at the water–energy nexus. A coupled trade and hydrological model is used to examine pressures on freshwater resources associated with energy production across the global economy. While the electric and gas sectors induce freshwater consumption predominantly within countries where demand originates (91% and 81%, respectively), the petroleum sector exhibits a high international footprint (56%). Critical geographic areas and economic sectors are identified, providing focus for resource-management actions to ensure energy and freshwater security. Our analysis demonstrates the importance of broadening the discourse on energy policy to address issues including freshwater scarcity, the role of international trade, and wider environmental and societal considerations. The growing geographic disconnect between consumption of goods, the extraction and processing of resources, and the environmental impacts associated with production activities makes it crucial to factor global trade into sustainability assessments. Using an empirically validated environmentally extended global trade model, we examine the relationship between two key resources underpinning economies and human well-being—energy and freshwater. A comparison of three energy sectors (petroleum, gas, and electricity) reveals that freshwater consumption associated with gas and electricity production is largely confined within the territorial boundaries where demand originates. This finding contrasts with petroleum, which exhibits a varying ratio of territorial to international freshwater consumption, depending on the origin of demand. For example, although the United States and China have similar demand associated with the petroleum sector, international freshwater consumption is three times higher for the former than the latter. Based on mapping patterns of freshwater consumption associated with energy sectors at subnational scales, our analysis also reveals concordance between pressure on freshwater resources associated with energy production and freshwater scarcity in a number of river basins globally. These energy-driven pressures on freshwater resources in areas distant from the origin of energy demand complicate the design of policy to ensure security of fresh water and energy supply. Although much of the debate around energy is focused on greenhouse gas emissions, our findings highlight the need to consider the full range of consequences of energy production when designing policy.
Control of Root Rot and Wilt Diseases of Roselle under Field Conditions

Abstract Roselle (Hibiscus sabdariffa L.) is one of the most important medicinal crops in many parts of the world. In this study, the effects of microelements, antioxidants, and bioagents on Fusarium oxysporum, F. solani, and Macrophomina phaseolina, the causal pathogens of root rot and wilt diseases in roselle, were examined under field conditions. Preliminary studies were carried out in vitro in order to select the most effective members to be used in field control trials. Our results showed that microelements (copper and manganese), antioxidants (salicylic acid, ascorbic acid, and EDTA), a fungicide (Dithane M45) and biological control agents (Trichoderma harzianum and Bacillus subtilis) were significantly reduced the linear growth of the causal pathogens. Additionally, application of the previous microelements, antioxidants, a fungicide and biological control agents significantly reduced disease incidence of root rot and wilt diseases under field conditions. Copper, salicylic acid, and T. harzianum showed the best results in this respect. In conclusion, microelements, antioxidants, and biocontrol agents could be used as alternative strategies to fungicides for controlling root rot and wilt diseases in roselle.
The Fps/Fes kinase regulates the inflammatory response to endotoxin through down‐regulation of TLR4, NF‐κB activation, and TNF‐α secretion in macrophages

Fps/Fes and Fer are members of a distinct subfamily of cytoplasmic protein tyrosine kinases that have recently been implicated in the regulation of innate immunity. Previous studies showed that mice lacking Fps/Fes are hypersensitive to systemic LPS challenge, and Fer‐deficient mice displayed enhanced recruitment of leukocytes in response to local LPS challenge. This study identifies physiological, cellular, and molecular defects that contribute to the hyperinflammatory phenotype in Fps/Fes null mice. Plasma TNF‐α levels were elevated in LPS challenged Fps/Fes null mice as compared with wild‐type mice and cultured Fps/Fes null peritoneal macrophages treated with LPS showed increased TNF‐α production. Cultured Fps/Fes null macrophages also displayed prolonged LPS‐induced degradation of IκB‐α, increased phosphorylation of the p65 subunit of NF‐κB, and defective TLR4 internalization, compared with wild‐type macrophages. Together, these observations provide a likely mechanistic basis for elevated proinflammatory cytokine secretion by Fps/Fes null macrophages and the increased sensitivity of Fps/Fes null mice to endotoxin. We posit that Fps/Fes modulates the innate immune response of macrophages to LPS, in part, by regulating internalization and down‐regulation of the TLR4 receptor complex.