Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypersymmetric functions and Pochhammers of 2×2 nonautonomous matrices

We introduce the hypersymmetric functions of 2×2 nonautonomous matrices and show that they are related, by simple expressions, to the Pochhammers (factorial polynomials) of these matrices. The hypersymmetric functions are generalizations of the associated elementary symmetric functions, and for a specific class of 2×2 matrices, having a high degree of symmetry, they reduce to these latter functions. This class of matrices includes rotations, Lorentz boosts, and discrete time generators for the harmonic oscillators. The hypersymmetric functions are defined over four sets of independent indeterminates using a triplet of interrelated binary partitions. We work out the algebra of this triplet of partitions and then make use of the results in order to simplify the expressions for the hypersymmetric functions for a special class of matrices. In addition to their obvious applications in matrix theory, in coupled difference equations, and in the theory of symmetric functions, the results obtained here also have useful applications in problems involving successive rotations, successive Lorentz transformations, discrete harmonic oscillators, and linear two-state systems.
Tackling Male Underachievement: Enhancing a Strengths-Based Learning Environment for Middle School Boys

During the past decade, there has been an increasing gender achievement gap with male students lagging behind their female counterparts on a number of important indicators of school success. This article examines recommendations and strategies for school counselors working with middle school boys to enhance the learning environment, to promote strengths, and to encourage positive attitudes toward academic achievement and future planning. Collaboration with teachers, administrators, parents, and community members as important stakeholders can offer combined resources to promote school success. The strategies described have resulted from a local collaborative action research project conducted by counselor educators and students, the county supervisor of guidance, and middle school counselors.
Influence of hydrocortisone succinate on intrarenal accumulation of gentamicin in endotoxemic rats

Gentamicin is a commonly used antibiotic in the treatment of gram-negative infections including septicemia and pyelonephritis. Bacterial endotoxin is liberated during antibiotic therapy and may lead to endotoxemic shock. Steroids such as hydrocortisone are generally recommended in the treatment of endotoxemic shock. There are very limited data on the influence of endotoxin or corticosteroids on the pharmacology of antibiotics, especially aminoglycosides, which are nephrotoxic. We studied the influence of both Escherichia coli endotoxin and hydrocortisone succinate on the renal uptake of gentamicin in rats. Animals were injected intravenously with endotoxin (0.25 mg/kg) and/or hydrocortisone (25 mg/kg) plus gentamicin (10 mg/kg). Gentamicin levels in the serum and renal parenchyma as well as renal function and histology were evaluated. Both endotoxin and hydrocortisone given alone increased the concentration of gentamicin in the renal cortex (P less than 0.05). Normal values in serum were observed in all groups at most time intervals. When administered together, endotoxin and hydrocortisone did not potentiate each other. The combination of endotoxin and hydrocortisone gave significantly higher levels of gentamicin than endotoxin or hydrocortisone alone when endotoxin was injected 3 h before hydrocortisone (P less than 0.05). Blood pressure and cardiac frequency were normal when gentamicin was given. Endotoxin alone slightly decreased the glomerular filtration rate, and hydrocortisone alone slightly modified renal plasma flow. The combination of both drugs did not significantly affect renal function. No histological lesion was noted on light microscopy in animals receiving endotoxin. Competitive or synergistic activity of endotoxin, gentamicin, and hydrocortisone at the cellular level, especially on membranes or lysosomes, might explain in part our observation on the renal uptake of gentamicin. By increasing the total amount of drug within the kidney, endotoxin and hydrocortisone might increase the risk of nephrotoxicity associated with aminoglycosides.
Irvalec Inserts into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells

Irvalec is a marine-derived antitumor agent currently undergoing phase II clinical trials. In vitro, Irvalec induces a rapid loss of membrane integrity in tumor cells, accompanied of a significant Ca2+ influx, perturbations of membrane conductivity, severe swelling and the formation of giant membranous vesicles. All these effects are not observed in Irvalec-resistant cells, or are significantly delayed by pretreating the cells with Zn2+. Using fluorescent derivatives of Irvalec it was demonstrated that the compound rapidly interacts with the plasma membrane of tumor cells promoting lipid bilayer restructuration. Also, FRET experiments demonstrated that Irvalec molecules localize in the cell membrane close enough to each other as to suggest that the compound could self-organize, forming supramolecular structures that likely trigger cell death by necrosis through the disruption of membrane integrity.
LABOCA observations of giant molecular clouds in the southwest region of the Small Magellanic Cloud

Context. The amount of molecular gas is a key for understanding the future star formation in a galaxy. Because H2 is diffi cult to observe directly in dense and cold clouds, tracers like the CO molecule are used. However, at low metallicities especially, CO only traces the shielded interiors of the clouds. In this context , millimeter dust emission can be used as a tracer to unveil the total dense gas masses. However, the comparison of masses deduced from the continuum SIMBA 1.2 mm emission and virial masses (thought to trace the whole potential of the clouds) in a sample of giant molecular clouds in the Small Magellanic Cloud (SMC) by Rubio et al. (2004) and Bot et al. (2007) showed a discrepancy between these two quantities that is in need of an explanation. Aims. This study aims at better assessing possible uncertainties on the dust emission observed in the sample of giant molecular clouds from the SMC. It focuses on the mass comparison in the densest parts of the giant molecular clouds where CO is detected in order to confirm the mass discrepancy observed. Methods. New observations of the south-west region of the SMC were obtained with the LABOCA camera on the APEX telescope. All the giant molecular clouds previously observed in CO are detected and their emission at 870� m is compared to ancillary data. The different contributions to the sub-millimeter emission are est imated, as well as dust properties (temperatures, emissivi ties), in order to deduce molecular cloud masses precisely. Results. The (sub-)millimeter emission observed in the giant molecular clouds in the south west region of the SMC is dominated by dust emission and masses are deduced for the part of each cloud where CO is detected and compared to the virial masses. The mass discrepancy between both methods is confirmed at 870� m with the LABOCA observations: the virial masses are on average 4 times smaller than the masses of dense gas deduced from dust emission, contrary to what is observed for equivalent clouds in our Galaxy. Conclusions. At present, the origin of this mass discrepancy in the SMC remains unkown. The direct interpretation of this effect is that the CO linewidth used to compute virial masses do not measure the full velocity distribution of the gas. Geometrical effects and uncertainties on the dust properties are also discussed.
Cognitive Strategy Instruction for Adolescents: What We Know about the Promise, What We Don't Know about the Potential

"Strategy instruction" is quickly becoming one of the most common — and perhaps the most commonly misunderstood — components of adolescent literacy research and practice. In this essay, veteran teacher educator Mark Conley argues that a particular type of strategy instruction known as cognitive strategy instruction holds great promise for improving adolescents' reading, writing, and thinking across content areas. However, he further suggests that we do not yet have the research needed to adequately understand and maximize the potential of cognitive strategy instruction in secondary content-area classrooms. After situating cognitive strategy instruction in the larger context of research on adolescent literacy and school-to-work transitions, Conley provides classroom examples of cognitive strategy instruction, demonstrates the need for meaningful integration of cognitive strategies in teacher education, and recommends specific directions for future research needed to understand and maximize the benefits of .
Optimal Asymptotic Entrainment of Phase-Reduced Oscillators

We derive optimal periodic controls for entrainment of a self-driven oscillator to a desired frequency. The alternative objectives of minimizing power and maximizing frequency range of entrainment are considered. A state space representation of the oscillator is reduced to a linearized phase model, and the optimal periodic control is computed from the phase response curve using formal averaging and the calculus of variations. Computational methods are used to calculate the periodic orbit and the phase response curve, and a numerical method for approximating the optimal controls is introduced. Our method is applied to asymptotically control the period of spiking neural oscillators modeled using the Hodgkin-Huxley equations. This example illustrates the optimality of entrainment controls derived using phase models when applied to the original state space system.
Influence of Sulfobacillus thermosulfidooxidans on Initial Attachment and Pyrite Leaching by Thermoacidophilic Archaeon Acidianus sp. DSM 29099

At the industrial scale, bioleaching of metal sulfides includes two main technologies, tank leaching and heap leaching. Fluctuations in temperature caused by the exothermic reactions in a heap have a pronounced effect on the growth of microbes and composition of mixed microbial populations. Currently, little is known on the influence of pre-colonized mesophiles or moderate thermophiles on the attachment and bioleaching efficiency by thermophiles. The objective of this study was to investigate the interspecies interactions of the moderate thermophile Sulfobacillus thermosulfidooxidans DSM 9293T and the thermophile Acidianus sp. DSM 29099 during initial attachment to and dissolution of pyrite. Our results showed that: (1) Acidianus sp. DSM 29099 interacted with S. thermosulfidooxidansT during initial attachment in mixed cultures. In particular, cell attachment was improved in mixed cultures compared to pure cultures alone; however, no improvement of pyrite leaching in mixed cultures compared with pure cultures was observed; (2) active or inactivated cells of S. thermosulfidooxidansT on pyrite inhibited or showed no influence on the initial attachment of Acidianus sp. DSM 29099, respectively, but both promoted its leaching efficiency; (3) S. thermosulfidooxidansT exudates did not enhance the initial attachment of Acidianus sp. DSM 29099 to pyrite, but greatly facilitated its pyrite dissolution efficiency. Our study provides insights into cell-cell interactions between moderate thermophiles and thermophiles and is helpful for understanding of the microbial interactions in a heap leaching environment.
Antithrombin III and trauma patients: factors that determine low levels.

A prospective (cohort) study was conducted to determine the incidence of low antithrombin III (AT III) levels and the association with selected clinical variables in adult trauma patients. One hundred sixty AT III levels were obtained on 50 consecutive trauma admissions to a community-based level I trauma center. Antithrombin III levels were drawn as soon after admission as possible and every other day thereafter. Thirty-one patients (62%) had at least one low AT III level (< 80%), whereas 15 concurrently drawn control levels were all > or = 90%. Low AT III levels were more common in patients with one or more of the following: base deficit less than -4 (39% vs. 0, p = 0.002); Injury Severity Score > 15 (48% vs. 16%, p = 0.04); and blood transfusion (32% vs. 5%, p = 0.04). All other variables (shock, surgical intervention, subcutaneous heparin, and sequential compression devices) were not statistically significant, although all six patients with shock had low levels. In conclusion, over 60% of adult trauma patients had low AT III levels at some time during hospitalization and these patients were clearly more severely injured. Further studies are required to determine if these patients are more susceptible to thromboembolic phenomena.
Chemical composition and bioactivity of essential oils of Hypericum helianthemoides. Hypericum perforatum and Hypericum scabrum

Abstract Context: A number Hypericum species are well known for their therapeutic efficacy and use in traditional medicine. The various species of Hypericum have been traditionally used for the treatment of wounds, eczema, burns, trauma, rheumatism, neuralgia, gastroenteritis, ulcers, hysteria, bedwetting and depression. Objective: This study evaluated the in vitro antioxidant, antibacterial and phytochemical properties of essential oils of Hypericum helianthemoides (Spach) Boiss. , Hypericum perforatum L. and Hypericum scabrum L. (Hypericaceae) collected from alpine region of Southwest Iran. Materials and methods: The essential oils obtained from dried flowering aerial parts of three Hypericum species were analyzed by gas chromatography and gas chromatography/mass spectrometry to determine chemical compositions. The antibacterial activity of essential oils within concentration ranges from 16 to 500 µg/mL was individually evaluated against Bacillus cereus, Listeria monocytogenes. Proteus vulgaris and Salmonella typhimurium. The 1,1-diphenyl-2-picrilhydrazyl (DPPH) radical scavenging activity of essential oils was determined using DPPH assay. Results: Essential oil yield of H. helianthemoides. H. scabrum and H. perforatum were 0.12, 0.20 and 0.21 mL/100 g dried material, respectively. The major constituents of the essential oils were α-pinene (12.52–49.96%), β-pinene (6.34–9.70%), (E)-β-ocimene (4.44–12.54%), β-caryophyllene (1.19–5.67%), and germacrene-D (2.34–6.92%). The essential oils of three Hypericum species indicated moderate-to-good inhibitory activities against four bacteria, especially against L. monocytogenes. Discussion and conclusion: The essential oils of the three studied Hypericum species sourced in alpine region of West Iran were rich in monoterpene and sesquiterpenes hydrocarbons. Among the three tested species, the essential oil of H. scabrum showed the highest antibacterial and antioxidant activities.
How Much Does It Cost to Improve Access to Voluntary Medical Male Circumcision among High-Risk, Low-Income Communities in Uganda?

Background The Ugandan Ministry of Health has endorsed voluntary medical male circumcision as an HIV prevention strategy and has set ambitious goals (e.g., 4.2 million circumcisions by 2015). Innovative strategies to improve access for hard to reach, high risk, and poor populations are essential for reaching such goals. In 2009, the Makerere University Walter Reed Project began the first facility-based VMMC program in Uganda in a non-research setting. In addition, a mobile clinic began providing VMMC services to more remote, rural locations in 2011. The primary objective of this study was to estimate the average cost of performing VMMCs in the mobile clinic compared to those performed in health facilities (fixed sites). The difference between such costs is the cost of improving access to VMMC. Methods A micro-costing approach was used to estimate costs from the service provider’s perspective of a circumcision. Supply chain and higher-level program support costs are not included. Results The average cost (US$2012) of resources used per circumcision was $61 in the mobile program ($72 for more remote locations) compared to $34 at the fixed site. Costs for community mobilization, HIV testing, the initial medical exam, and staff for performing VMMC operations were similar for both programs. The cost of disposable surgical kits, the additional upfront cost for the mobile clinic, and additional costs for staff drive the differences in costs between the two programs. Cost estimates are relatively insensitive to patient flow over time. Conclusion The MUWRP VMMC program improves access for hard to reach, relatively poor, and high-risk rural populations for a cost of $27-$38 per VMMC. Costs to patients to access services are almost certainly less in the mobile program, by reducing out-of-pocket travel expenses and lost time and associated income, all of which have been shown to be barriers for accessing treatment.
Assisted Visualization of E-Commerce Auction Agents

This paper describes the integration of perceptual guidelines from human vision with an Al-based mixed-initiative search technique. The result is a visualization assistant, a system that identifies perceptually salient visualizations for large, multidimensional collections of data. Understanding how the low-level human visual system "sees" visual information in an image allows us to: (1) evaluate a particular visualization, and (2) direct the search algorithm towards new visualizations that may be better than those seen to date. In this way we can limit search to locations that have the highest potential to contain effective visualizations. One testbed application for this work is the visualization of intelligent e-commerce auction agents participating in a simulated online auction environment. We describe how the visualization assistant was used to choose methods to effectively visualize this data.
BASIC SCIENCE REVIEW

Background. Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important therapeutic target in head and neck squamous cell carcinoma (HNSCC). The basis for the lack of correlation between EGFR expression in the HNSCC tumor and clinical responses to EGFR inhibitors is incompletely understood. Although a variety of mechanisms likely contribute to the effectiveness of EGFR blockade, this review focuses on the biologic implications of known EGFR variations and the role of the immune system in mediating clinical responses to EGFR inhibitors. Methods. A Medline review of articles published in the last 10 years (1999–present) on EGFR in HNSCC was performed in combination with preliminary data from our laboratories. Results. Studies published to date suggest no association between the expression of EGFR on HNSCC tumors and clinical responses to EGFR inhibitors. Several mechanisms have been proposed to mediate clinical response to EGFR inhibitors in HNSCC. Cumulative results from our laboratories support the role of several mechanisms, including cellular immune activation and mutated EGFR variants, in contributing to the discrepancy between level of EGFR expression and clinical response to EGFR inhibitors. Conclusion. The efficacy of EGFR targeted therapies may be mediated, at least in part, by the immune system and the presence of the truncated EGFR variant, EGFRvIII, among other factors. Criteria to identify the subset of patients likely to be responsive to EGFR targeted therapies are needed. VC 2010 Wiley Periodicals, Inc. Head Neck 32: 1412–1421, 2010
Isolated axillary nodal swelling and cancer of unknown primary.

INTRODUCTION The literature reports rare cases of isolated axillary lymph node metastasis from cancer of unknown primary (CUP). The authors reviewed the prevalence and outcome of patients with isolated axillary nodal swelling suspicious for malignancy affected or not by isolated axillary node metastasis from CUP. MATERIALS AND METHODS The authors collected data about 65 patients presented with isolated axillary lymph node swelling who underwent axillary lymph node excisional biopsy for malignancy suspicion, between January 2005 and December 2011, in the absence of any specific diagnosis. RESULTS Histological examination revealed a metastatic infiltration by an occult solid cancer in 16 cases (24%), ten of which were occult breast cancers. Histological patterns and molecular markers allowed in all cases of occult cancer a probable identification of the primary tumor site, while a definitive diagnosis was possible only in the 56.25% of cases (9/16). The prognosis of these patients was very poor with a five-year overall survival of 28%, and thus very similar to patients affected by Stage IV overt breast cancer. CONCLUSIONS Among occult malignancies presenting with sole axillary lymph node metastasis, breast cancer remains the more probable primary cancer, but many other sites should be taken into consideration by negative breast imaging. Positron-emission tomography computed tomography (PET-CT) resulted helpful in the primary site detection, but has nonetheless a margin of failure. Occult breast cancers behave very similar to Stage IV overt breast cancers, and should be treated accordingly.
DL-ReSuMe: A Delay Learning-Based Remote Supervised Method for Spiking Neurons

Recent research has shown the potential capability of spiking neural networks (SNNs) to model complex information processing in the brain. There is biological evidence to prove the use of the precise timing of spikes for information coding. However, the exact learning mechanism in which the neuron is trained to fire at precise times remains an open problem. The majority of the existing learning methods for SNNs are based on weight adjustment. However, there is also biological evidence that the synaptic delay is not constant. In this paper, a learning method for spiking neurons, called delay learning remote supervised method (DL-ReSuMe), is proposed to merge the delay shift approach and ReSuMe-based weight adjustment to enhance the learning performance. DL-ReSuMe uses more biologically plausible properties, such as delay learning, and needs less weight adjustment than ReSuMe. Simulation results have shown that the proposed DL-ReSuMe approach achieves learning accuracy and learning speed improvements compared with ReSuMe.
Relationship of weight, body dissatisfaction, and self-esteem in African American and white female dieters.

OBJECTIVE The present study examined the relationship among weight, body dissatisfaction, and self-esteem in a large group of African American and white female dieters who were generally overweight and of middle to high socioeconomic status. METHOD Subjects were participants in a survey of dieting practices undertaken by Consumer Reports magazine. Major outcome measures included the Rosenberg Self-Esteem Scale and an assessment of shape and weight attitudes. RESULTS No significant differences between African American and white women were found for body dissatisfaction, self-esteem, discrepancies between actual and ideal weight and shape, or the relationship between self-esteem and body dissatisfaction. Body mass index contributed less to body satisfaction scores in African American than in white women. DISCUSSION This study provides a comparison of African American and white women in the upper social classes, and raises the possibility that previous findings of less body concern in African American women reflect class rather than race effects.