Miracle-dz/UniFAR-FTUs huggingface dataset:
Periocular biometrics: When iris recognition fails

The performance of iris recognition is affected if iris is captured at a distance. Further, images captured in visible spectrum are more susceptible to noise than if captured in near infrared spectrum. This research proposes periocular biometrics as an alternative to iris recognition if the iris images are captured at a distance. We propose a novel algorithm to recognize periocular images in visible spectrum and study the effect of capture distance on the performance of periocular biometrics. The performance of the algorithm is evaluated on more than 11,000 images of the UBIRIS v2 database. The results show promise towards using periocular region for recognition when the information is not sufficient for iris recognition.
Possible role of plant volatiles in tolerance against huanglongbing in citrus

abstract Volatile organic compounds (VOC) play an important role in protecting plants from insect and pathogen attack. In this study, we investigated the leaf volatile profiles of 14 citrus varieties. The VOC in citrus leaves were extracted with n-hexane and analyzed using gas chromatography-mass spectrometry (GC-MS). Overall, 4six volatile compounds were identified in the n-hexane extract from citrus leaves. Most of the detected compounds belonged to 3 main groups (monoterpenes, sesquiterpenes, and aliphatic aldehydes). Principle component analysis was used to examine the relative distribution of the studied varieties to each other. Interestingly, volatile profiles of varieties that are tolerant to Candidatus Liberibacter asiaticus (CLas) were different from those of the susceptible ones. Tolerant and moderately-tolerant cultivars contained relatively higher amounts of volatiles than susceptible varieties. In addition, tolerant varieties were also higher in specific compounds which are known for their antimicrobial activities. These compounds include Aldehydes (undecanal, neral, geranial, and citronellal) and some monoterpenes such as linalool, d-limonene, myrcene, α- and β- phellandrene. In addition, some sesquiterpene compounds including t-caryophellene, γ-elemene, β-elemene, germacrene D, and geranyl acetate were higher in tolerant and moderately tolerant cultivars. Severinia buxifolia which is known for its tolerance to CLas and many other pathogens contained higher levels of santalenes and coumarins. Our results indicated that citrus leaf volatiles might play a role in citrus tolerance to CLas. The results of this study may help in understanding of the mechanism of citrus tolerance against CLas.
[Arthroscopic percutaneous osteosynthesis of low-energy tibial plateau fractures].

OBJECTIVE To explore the treatment of low-energy tibial plateau fractures with arthroscopic percutaneous osteosynthesis. METHODS From May 2004 to April 2008, 27 cases of tibial plateau fractures were treated with arthroscopic management. There were 19 males and 8 females, aged 18-61 years old (mean 41.5 years old). Fracture was caused by traffic accident in 18 cases, by falling from height in 6 cases, by bruise in 2 cases, and by other in 1 case. There were 8 cases of type I, 12 cases of type II, 2 cases of type III and 5 cases of type IV according to Schatzker classification. The time from injury to operation was 3-15 days (mean 5.2 days). After symptomatic managements were performed arthroscopically in 11 cases of meniscus tear, 4 cases of medial collateral ligament rupture of knee joint, 3 cases of anterior cruciate ligament rupture of knee joint and 2 cases of cartilage fracture resulting in joint bodies, fracture was reduced and fixed with 2 or 4 cannulated screws (7 mm in diameter). Autograft of ilium was given 6 cases of bone defect. Early functional exercise was done. RESULTS The operation time was 55-150 minutes (mean 93 minutes); the hospitalization days were 7-22 days (mean 16 days). All incision healed primarily. Edema of the affected leg occurred in all patients and subsided after 3 days of symptomatic management. In one patient who did not cooperate in functional exercise, adhesion occurred and normal function was recovered after by manual dissolution under conditions of anesthesia after 3 months of operation. All patients were followed up 6-36 months (mean 16.6 months). The range of motion of knee joint was 105-140 degrees (mean 121 degrees). According to Lysholm scale of knee joint, the score was 72-100 points (mean 93.6 points) 6 months after operation. The X-ray film showed no signs of osteoarthritis. CONCLUSION Arthroscopic percutaneous osteosynthesis yields satisfactory results and can be accepted as an alternative and effective method for the treatment of low-energy tibial plateau fractures.
Cytotoxic Effects of Tropodithietic Acid on Mammalian Clonal Cell Lines of Neuronal and Glial Origin

The marine metabolite tropodithietic acid (TDA), produced by several Roseobacter clade bacteria, is known for its broad antimicrobial activity. TDA is of interest not only as a probiotic in aquaculture, but also because it might be of use as an antibacterial agent in non-marine or non-aquatic environments, and thus the potentially cytotoxic influences on eukaryotic cells need to be evaluated. The present study was undertaken to investigate its effects on cells of the mammalian nervous system, i.e., neuronal N2a cells and OLN-93 cells as model systems for nerve cells and glia. The data show that in both cell lines TDA exerted morphological changes and cytotoxic effects at a concentration of 0.3–0.5 µg/mL (1.4–2.4 µM). Furthermore, TDA caused a breakdown of the mitochondrial membrane potential, the activation of extracellular signal-regulated kinases ERK1/2, and the induction of the small heat shock protein HSP32/HO-1, which is considered as a sensor of oxidative stress. The cytotoxic effects were accompanied by an increase in intracellular Ca2+-levels, the disturbance of the microtubule network, and the reorganization of the microfilament system. Hence, mammalian cells are a sensitive target for the action of TDA and react by the activation of a stress response resulting in cell death.
A life table and Cox regression analysis of patients with combined proximal left anterior descending and proximal left circumflex coronary artery disease: non-left main equivalent lesions (CASS).

Combined proximal left anterior descending and proximal left circumflex artery stenoses greater than or equal to 70% have been referred to as "left main equivalent" lesions. We compared the survival rates of medically treated patients who have this type of coronary anatomic characteristics with the survival rates of patients who have left main coronary artery stenoses greater than or equal to 70% by use of a stratified life table approach and a Cox regression model. Comparison of the patients with left main coronary artery stenoses with those who have left main equivalent lesions by use of life table analysis and three different calculations of patient exposure time revealed a poorer prognosis for the patients who had left main coronary artery disease (p less than or equal to .04 for all three methods). The stepwise Cox analysis also determined that patients who had left main artery stenoses had a significantly poorer prognosis than patients who had left main equivalent coronary disease (p = .002), even after consideration of important baseline variables known to affect survival rates. We then compared the patients who had combined proximal left anterior descending and proximal left circumflex artery disease with patients who had combined stenoses greater than or equal to 70% in the nonproximal left anterior descending stenosis influenced survival rates. The 5 year to determine if location of the left anterior descending stenosis influenced survival rates. The 5 year survival rate was not as high for the patients who had proximal left anterior descending artery disease (55% vs 70%, p = .001). In conclusion, combined proximal left anterior descending and proximal left circumflex artery disease identifies a high-risk (as determined by angiography) patient subset. (ABSTRACT TRUNCATED AT 250 WORDS)
Vector Gaussian Multiple Description with Individual and Central Receivers

L multiple descriptions of a vector Gaussian source for individual and central receivers are investigated. The sum rate of the descriptions with covariance distortion measure constraints, in a positive semidefinite ordering, is exactly characterised. For two descriptions, the entire rate region is characterized. Jointly Gaussian descriptions are optimal in achieving the limiting rates. The key component of the solution is a novel information-theoretic inequality that is used to lower bound the achievable multiple description rates
Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing Breast Cancer

The selective estrogen-receptor modulator (SERM) tamoxifen became the first U.S. Food and Drug Administration (FDA)–approved agent for reducing breast cancer risk but did not gain wide acceptance for prevention, largely because it increased endometrial cancer and thromboembolic events. The FDA approved the SERM raloxifene for breast cancer risk reduction following its demonstrated effectiveness in preventing invasive breast cancer in the Study of Tamoxifen and Raloxifene (STAR). Raloxifene caused less toxicity (versus tamoxifen), including reduced thromboembolic events and endometrial cancer. In this report, we present an updated analysis with an 81-month median follow-up. STAR women were randomly assigned to receive either tamoxifen (20 mg/d) or raloxifene (60 mg/d) for 5 years. The risk ratio (RR; raloxifene:tamoxifen) for invasive breast cancer was 1.24 (95% confidence interval [CI], 1.05–1.47) and for noninvasive disease, 1.22 (95% CI, 0.95–1.59). Compared with initial results, the RRs widened for invasive and narrowed for noninvasive breast cancer. Toxicity RRs (raloxifene:tamoxifen) were 0.55 (95% CI, 0.36–0.83; P = 0.003) for endometrial cancer (this difference was not significant in the initial results), 0.19 (95% CI, 0.12–0.29) for uterine hyperplasia, and 0.75 (95% CI, 0.60–0.93) for thromboembolic events. There were no significant mortality differences. Long-term raloxifene retained 76% of the effectiveness of tamoxifen in preventing invasive disease and grew closer over time to tamoxifen in preventing noninvasive disease, with far less toxicity (e.g., highly significantly less endometrial cancer). These results have important public health implications and clarify that both raloxifene and tamoxifen are good preventive choices for postmenopausal women with elevated risk for breast cancer. Cancer Prev Res; 3(6); 696–706. ©2010 AACR.
Nitrogen Metabolism and Yield Response to Increases in Nitrogen−Phosphorus Fertilization: Improvement in Greenhouse Cultivation of Eggplant (Solanum melongena Cv. Bonica)

The effect that application of nitrogen−phosphorus (NP) rates exerts on some parameters of nitrogen metabolism and on yield in aubergine plants (eggplant, Solanum melongena cv. Bonica) was studied. All plants were grown under controlled conditions in an experimental greenhouse. The treatments consisted of the combination of three rates of N in the form of KNO3 (N1: 15 g m-2, N2: 22.5 g m,-2 and N3: 30 g m-2) together with two rates of P in the form of H3PO4 (P1: 24 g m-2 and P2: 36 g m-2), for a total of six treatments. Results indicate that regardless of the P rate applied, an increase in the N fertilizer increased NO3- assimilation as well as total and commercial yield. Use of the P2 rate favored all of these processes in comparison with the results obtained with the P1 rate, in addition to notably reducing the foliar levels of NO3- and noncommercial yield. Keywords: Solanum melongena L. ; NP fertilization; nitrogen assimilation; yield
Electrochemical Characterization of Guanine and Guanosine Based Biosensors Over Multi-Walled Carbon Nanotube Modified Graphite Electrode

Electroactive purine nucleobase, guanine and purine nucleoside, guanosine were immobilized over multi-walled carbon nanotubes (MWCNT) modified graphite electrode. The electrooxidation properties of purines were evaluated using differential pulse voltammetry. Mixtures of purine nucleobase and nucleoside in various concentrations were prepared and electrochemically immobilized over the working electrodes using positive potential difference. The anodic current at around 0.7 V was used as analytical signal for guanine. The influence of immobilization time, MWCNT concentration and purine concentration were evaluated and electrochemical mechanisms have been discussed. Special emphasis was given to study the stable recognition layer in a redox couple (0.1M NaCl containing 10/10 mM K3Fe(CN)6/K4Fe(CN)6) using electrochemical impedance spectroscopy and cyclic voltammetry. Further, electrochemical interaction of immobilized purine structures over benzene substituted organic compounds were studied using DPV in 0.1M phosphate buffer, and CV and EIS in 0.1 M NaCl containing 10/10 mM K3Fe(CN)6/K4Fe(CN)6. The standardized and calibrated purine immobilized electrode could be potentially used as purine based biosensor for the electrochemical detection of benzene substituted organic compounds.
Flow cytometric quantitation of red blood cell vesicles in thalassemia

Thalassemia is a hereditary hemolytic anemia caused by mutations in the globin gene complex. Circulatory disturbances including arterial and venous thrombosis have also been noted in these patients. Aggregability of abnormal RBC and the high level of membrane‐derived microparticles stemming from activated platelets and other blood cells are thought to be responsible for the associated thrombotic risk. Destruction of RBC is also thought to be an important pathophysiological consequence, particularly through the formation of circulating vesicles. To our knowledge, there has been no attempt to quantitatively evaluate the number of RBC vesicles in thalassemia. This prompted us to study the level of RBC vesicles in the peripheral blood of thalassemia patients using quantitative flow cytometry.
Epistemic motivation affects the processing of negative emotional stimuli in interpersonal decisions

The present electrophysiological study investigated the role of the need for cognitive closure (NFC) in emotional processing. The NFC is conceptualized as an epistemic motive that is related to how and why people seek out information in social environments. Event-related potentials were recorded while individuals with high NFC (i.e., low epistemic motivation) or low NFC (i.e., high epistemic motivation) performed a modified Ultimatum Game, in which the emotions of happy or angry game agents were employed to predict their most likely offer. High-NFC participants more closely adhered to the decisions rules of the game than low-NFC individuals did. The electrophysiological results showed that the dispositional NFC modified early perceptual components (N170, N200, and P200). The potentials showed that high-NFC subjects had a processing bias to angry faces, whereas low-NFC individuals exhibited no such effects. These findings indicated that high-NFC individuals were more sensitive to negative emotional stimuli than low-NFC individuals in an interpersonal decision-making task.
Ligament Reconstruction Surgery Psychological Responses Matter in Returning to Preinjury Level of Sport After Anterior Cruciate

http://ajs.sagepub. com/content/41/7/1549 The online version of this article can be found at: DOI: 10.1177/0363546513489284 2013 41: 1549 originally published online June 3, 2013 Am J Sports Med Clare L. Ardern, Nicholas F. Taylor, Julian A. Feller, Timothy S. Whitehead and Kate E. Webster Ligament Reconstruction Surgery Psychological Responses Matter in Returning to Preinjury Level of Sport After Anterior Cruciate
Root Herbivores Drive Changes to Plant Primary Chemistry, but Root Loss Is Mitigated under Elevated Atmospheric CO2

Above- and belowground herbivory represents a major challenge to crop productivity and sustainable agriculture worldwide. How this threat from multiple herbivore pests will change under anthropogenic climate change, via altered trophic interactions and plant response traits, is key to understanding future crop resistance to herbivory. In this study, we hypothesized that atmospheric carbon enrichment would increase the amount (biomass) and quality (C:N ratio) of crop plant resources for above- and belowground herbivore species. In a controlled environment facility, we conducted a microcosm experiment using the large raspberry aphid (Amphorophora idaei), the root feeding larvae of the vine weevil (Otiorhynchus sulcatus), and the raspberry (Rubus idaeus) host-plant. There were four herbivore treatments (control, aphid only, weevil only and a combination of both herbivores) and an ambient (aCO2) or elevated (eCO2) CO2 treatment (390 versus 650 ± 50 μmol/mol) assigned to two raspberry cultivars (cv Glen Ample or Glen Clova) varying in resistance to aphid herbivory. Contrary to our predictions, eCO2 did not increase crop biomass or the C:N ratio of the plant tissues, nor affect herbivore abundance either directly or via the host-plant. Root herbivory reduced belowground crop biomass under aCO2 but not eCO2, suggesting that crops could tolerate attack in a CO2 enriched environment. Root herbivory also increased the C:N ratio in leaf tissue at eCO2, potentially due to decreased N uptake indicated by lower N concentrations found in the roots. Root herbivory greatly increased root C concentrations under both CO2 treatments. Our findings confirm that responses of crop biomass and biochemistry to climate change need examining within the context of herbivory, as biotic interactions appear as important as direct effects of eCO2 on crop productivity.
Adverse reproductive effects of maternal low‐dose melamine exposure during pregnancy in rats

Melamine is a heterocyclic, aromatic amine and nitrogen‐enriched environmental toxicant, found in not only adulterated foodstuffs but also industrial household tableware and paints. Previous studies demonstrated adverse effects of high‐dose melamine on human infants and pregnant animals, but effects of low‐dose melamine on pregnancy have not been reported. In this study, reproductive effects of low‐dose melamine were investigated in pregnant rats. Melamine in the range of 12.5–50 mg/kg was administered to pregnant rats at different gestational stages. Maternal weight gain was not significantly affected, and other maternal morbidity was not observed. Low‐dose melamine exposure during pregnancy increased fetal size but reduced somite number in gastrulation (GD8.5–GD10.5) and organogenesis (GD10.5–GD16.5) periods, and increased incidence of stillbirth in whole gestational period (GD0.5 to delivery). Embryotoxicity of melamine was further confirmed by whole embryo culture in vitro that melamine retarded embryonic growth, impaired development of brain and heart, and induced open neural tube and atrioventricular defects with increased apoptosis. In conclusion, adverse reproductive effects of low‐dose melamine during pregnancy were identified in the developing rat embryos and the perinatal effects of melamine were gestational and developmental stage dependent. Detailed hazard and risk assessment of melamine in reproduction system are warrant. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 131–138, 2017.
Genetic classification of colorectal cancer based on chromosomal loss and microsatellite instability predicts survival.

PURPOSE Colorectal cancers harbor one of two distinct alterations, unilateral chromosomal loss as evidenced by a loss of heterozygosity (LOH) and microsatellite instability (MSI), as represented by the widespread insertion or deletion of simple repeat nucleotides. We investigated the relationships between the clinicopathological features and microsatellite alterations (LOH and MSI) of 168 colorectal cancers. EXPERIMENTAL DESIGN The concerted and individual effects of various chromosomal losses on survival were comparatively analyzed using a reference panel of 40 microsatellite markers in eight cancer-related chromosomes, 3p, 4p, 5q, 8p, 9p, 13q, 17p, and 18q. RESULTS Of the 168 colorectal cancers tested, 29 (17%) with high-frequency MSI were associated with good survival (P < 0.05). The extent of LOH detected in 139 (83%) cases without MSI was classified as low level involving three or fewer arms (35%), moderate level involving four arms (22%), or high level involving five or more arms (43%). High-level loss correlated with earlier onset, lymphatic invasion, and rectal location, whereas low-level loss was more common in proximal colon and stages I and II (P < 0.05). The survival curve and multivariate analysis identified high- and low-level chromosomal loss as the most significant predictor of poor and good survival, respectively (log-rank test, P < 0.0001), in patients with stage II (hazard ratio, 6.27; 95% confidence interval, 1.99-19.7; P = 0.0017) and those with stage III (hazard ratio, 10.89; 95% confidence interval, 2.54-46.77; P = 0.0013). Moderate chromosomal loss showed dual prognostic values associated with favorable stage II and unfavorable stage III. Single chromosomal losses tended to play a role as a part of the concerted chromosomal function. CONCLUSION The classification of colorectal cancer based on chromosomal loss and MSI provides a prognostic index that reflects tumor pathobiology.
Discovering localized attributes for fine-grained recognition

Attributes are visual concepts that can be detected by machines, understood by humans, and shared across categories. They are particularly useful for fine-grained domains where categories are closely related to one other (e.g. bird species recognition). In such scenarios, relevant attributes are often local (e.g. “white belly”), but the question of how to choose these local attributes remains largely unexplored. In this paper, we propose an interactive approach that discovers local attributes that are both discriminative and semantically meaningful from image datasets annotated only with fine-grained category labels and object bounding boxes. Our approach uses a latent conditional random field model to discover candidate attributes that are detectable and discriminative, and then employs a recommender system that selects attributes likely to be semantically meaningful. Human interaction is used to provide semantic names for the discovered attributes. We demonstrate our method on two challenging datasets, Caltech-UCSD Birds-200-2011 and Leeds Butterflies, and find that our discovered attributes outperform those generated by traditional approaches.
Th1 and Th2 cytokine profiles in malignant pleural effusion.

BACKGROUND The alteration of Th1 and Th2 cytokine levels is the subject of controversy in pleural effusions caused by malignancy, a situation that favors a Th2 immune response. OBJECTIVE To examine the different levels of IL-4 and IL-10 (Th2 cytokines), and IL-2 and interferon-γ (IFN-γ) (Th1 cytokines) in malignant and non-malignant pleural effusions. METHOD The cytokine levels in pleural fluid of 62 patients with malignant pleural effusion (44 with lung cancer and 18 with extrathoracic tumors), 8 with tuberculous and 8 with congestive heart failure pleural effusion were analyzed using enzyme-linked immunosorbent assays. RESULTS IL-2 was below the detectable concentration of the assay. A significant decrease in IFN-γ level was observed in malignant but not in congestive heart failure cases compared to tuberculous cases. IL-10 levels were higher in malignant and tuberculous pleural effusions than in congestive heart failure pleural effusions, however, this difference did not reach the significant level. IL-4 levels were also increased non-significantly in lung cancer pleural effusions compared to the other groups. CONCLUSION Our results show a wide variation in IL-4, IL-10, and IFN-γ levels in malignant pleural effusions, a pattern which was not convincing enough to differentiate the cause of effusion.