Miracle-dz/UniFAR-FTUs huggingface dataset:
A three‐dimensional synthesis study of δ18O in atmospheric CO2 2. Simulations with the TM2 transport model

In this study, using a three-dimensional (3-D) tracer modeling approach, we simulate the •80 of atmospheric CO2. In the atmospheric transport model TM2 we prescribe the surface fluxes of •80 due to vegetation and soils, ocean exchange, fossil emissions, and biomass burning. The model simulations are first discussed for each reservoir separately, then all the reservoirs are combined to allow a comparison with the atmospheric •80 measurements made by the National Oceanic and Atmospheric Administration-University of Colorado, Scripps Institution of Oceanography-Centrum Voor Isotopen Onderzoek (United States-Netherlands) and Commonwealth Scientific and Industrial Research Organisation (Australia) air sampling programs. Insights into the latitudinal differences and into the seasonal cycle of •80 in CO2 are gained by looking at the contribution of each source. The isotopic exchange with soils induces a large isotopic depletion over the northern hemisphere continents, which overcomes the concurrent effect of isotopic enrichment due to leaf exchange. Compared to the land biota, the ocean fluxes and the anthropogenic CO2 source have a relatively minor influence. The shape of the latitudinal profile in •80 appears determined primarily by the respiration of the land biota, which balances photosynthetic uptake over the course of a year. Additional information on the phasing of the terrestrial carbon exchange comes from the seasonal cycle of •80 at high northern latitudes.
Investigation of developed precipitates in Al–1·1 wt-%Mg2Si balanced alloy by DSC and SEM techniques

Abstract The effect of temperature on the sequence of the hardening precipitates in Al–1·1 wt-%Mg2Si balanced alloy has been investigated by means of differential scanning calorimetry, scanning electron microscopy and hardness measurements. The non-isothermal DSC thermograms exhibited seven reaction peaks. Out of these seven peaks, five are exothermic (representing precipitation) and two are endothermic (representing dissolution). The activation energy associated with the individual precipitates is calculated. The activation energy of nucleation of GP zones (54·3 kJ mol−1) is close to the migration energy of Si in Al (52·7 kJ mol−1). The activation energy associated with the precipitation of β″ is determined as 77·6 kJ mol−1 and that for the formation of β′ precipitates is 145·3 kJ mol−1. The latter value is close to that for Si diffusion in Al (124 kJ mol−1) and that of Mg diffusion in Al (131 kJ mol−1). It can be concluded that the precipitation of β′ particles might be characterised by both the diffusion of Mg and Si atoms in Al to form β′ precipitates.
GEV-Canonical Regression for Accurate Binary Class Probability Estimation when One Class is Rare

We consider the problem of binary class probability estimation (CPE) when one class is rare compared to the other. It is well known that standard algorithms such as logistic regression do not perform well in this setting as they tend to underestimate the probability of the rare class. Common fixes include under-sampling and weighting, together with various correction schemes. Recently, Wang & Dey (2010) suggested the use of a parametrized family of asymmetric link functions based on the generalized extreme value (GEV) distribution, which has been used for modeling rare events in statistics. The approach showed promising initial results, but combined with the logarithmic CPE loss implicitly used in their work, it results in a non-convex composite loss that is difficult to optimize. In this paper, we use tools from the theory of proper composite losses (Buja et al., 2005; Reid & Williamson, 2010) to construct a canonical underlying CPE loss corresponding to the GEV link, which yields a convex proper composite loss that we call the GEV-canonical loss; this loss can be tailored to CPE settings where one class is rare, and is easily minimized using an IRLS-type algorithm similar to that used for logistic regression. Our experiments on both synthetic and real data suggest that the resulting algorithm - which we term GEV-canonical regression - performs well compared to common approaches such as undersampling and weights-correction for this problem.
Comparison of Quality Traits of Meat from Korean Native Chickens and Broilers Used in Two Different Traditional Korean Cuisines

With the aim of investigating the differences in the quality traits between Korean native chicken (Hanhyup, KNC) and broilers commonly used in two different traditional Korean cuisines, the chemical composition and sensory properties of breast and thigh meat from the two chicken strains were assessed. KNC for baeksuk (chicken meat braised in soup with various Oriental medicinal plants; KNL), KNC for samgyetang (similar to baeksuk but young chickens and ginseng are used; KNS), broiler for baeksuk (BL), and broiler for samgyetang (BS) were used as treatments in this study. KNL and KNS contained higher protein but lower fat content than BL and BS. The L* values of breast and thigh meat, but not the a* values, were significantly different between KNS and BS, whereas significant differences in both values were observed between KNL and BL. Compared to the other three types of chickens, KNS contained the highest total and insoluble collagen content, and KNL and BL showed higher inosine-5’-monophosphate content in their meat. Overall, KNL and KNS contributed darker, less tender meat with higher protein and less fat content together with more n-3 fatty acids, as opposed to their counterparts used for the same cuisines. Based on the results of the sensory analysis, even though there are some differences in physiochemical traits, different chicken sources do not differ in overall sensory quality. This information can help consumers to understand better the meat available for their preferred traditional cuisines.
Savant-like Numerosity Skills Revealed in Normal People by Magnetic Pulses

Oliver Sacks observed autistic twins who instantly guessed the exact number of match-sticks that had just fallen on the floor, saying in unison “111”. To test the suggestion that normal individuals have the capacity for savant numerosity, we temporarily simulated the savant condition in normal people by inhibiting the left anterior temporal lobe of twelve participants with repetitive transcranial magnetic stimulation (rTMS). This site has been implicated in the savant condition. Ten participants improved their ability to accurately guess the number of discrete items immediately following rTMS and, of these, eight became worse at guessing as the effects of the pulses receded. The probability of as many as eight out of twelve people doing best just after rTMS and not after sham stimulation by chance alone is less than one in one thousand.
Automatic image captioning

We examine the problem of automatic image captioning. Given a training set of captioned images, we want to discover correlations between image features and keywords, so that we can automatically find good keywords for a new image. We experiment thoroughly with multiple design alternatives on large datasets of various content styles, and our proposed methods achieve up to a 45% relative improvement on captioning accuracy over the state of the art.
Competitive Mixtures of Simple Neurons

We propose a competitive finite mixture of neurons (or perceptrons) for solving binary classification problems. Our classifier includes a prior for the weights between different neurons such that it prefers mixture models made up from neurons having classification boundaries as orthogonal to each other as possible. We derive an EM algorithm for learning the mixing proportions and weights of each neuron, consisting of an exact E step and a partial M step, and show that our model covers the regions of high posterior probability in weight space and tends to reduce overfitting. We demonstrate the way in which our mixture classifier works using a toy 2D data set, showing the effective use of strategically positioned components in the mixture. We further compare its performance against SVMs and one-hidden-layer neural networks on four real-world data sets from the UCI repository, and show that even a relatively small number of neurons with appropriate competitive priors can achieve superior classification accuracies on held-out test data
mHealth in Sub-Saharan Africa

Mobile phone penetration rates have reached 63% in sub-Saharan Africa (SSA) and are projected to pass 70% by 2013. In SSA, millions of people who never used traditional landlines now use mobile phones on a regular basis. Mobile health, or mHealth, is the utilization of short messaging service (SMS), wireless data transmission, voice calling, and smartphone applications to transmit health-related information or direct care. This systematic review analyzes and summarizes key articles from the current body of peer-reviewed literature on PubMed on the topic of mHealth in SSA. Studies included in the review demonstrate that mHealth can improve and reduce the cost of patient monitoring, medication adherence, and healthcare worker communication, especially in rural areas. mHealth has also shown initial promise in emergency and disaster response, helping standardize, store, analyze, and share patient information. Challenges for mHealth implementation in SSA include operating costs, knowledge, infrastructure, and policy among many others. Further studies of the effectiveness of mHealth interventions are being hindered by similar factors as well as a lack of standardization in study design. Overall, the current evidence is not strong enough to warrant large-scale implementation of existing mHealth interventions in SSA, but rapid progress of both infrastructure and mHealth-related research in the region could justify scale-up of the most promising programs in the near future.
RelA Protein Is Involved in Induction of Genetic Competence in Certain Bacillus subtilis Strains by Moderating the Level of Intracellular GTP

ABSTRACT We found that the ability to develop genetic competence of a certain relaxed (relA) aspartate-auxotrophic strain of Bacillus subtilis is significantly lower than that of the isogenic stringent (relA+) strain. Transcriptional fusion analysis utilizing a lacZ reporter gene indicated that the amount of the ComK protein, known as the key protein for competence development, is greatly reduced in the relaxed strain than in the stringent strain. We also found that the addition of decoyinine, a GMP synthetase inhibitor, induces expression of a competence gene (comG) in the relaxed strain, accompanied by a pronounced decrease in the level of intracellular GTP as measured by high-performance liquid chromatography. The transformation efficiency of the relaxed strain increased 100-fold when decoyinine was added at t0 (the transition point between exponential to stationary growth phase). Conversely, supplementation of guanosine together with decoyinine completely abolished the observed effect of adding decoyinine on competence development. Furthermore, the impaired ability of the relaxed strain for competence development was completely restored by disrupting the codY gene, which is known to negatively control comK expression. Our results indicate that the RelA protein plays an essential role in the induction of competence development at least under certain physiological conditions by reducing the level of intracellular GTP and overcoming CodY-mediated regulation.
Replica-Request Priority Donation: A Real-Time Progress Mechanism for Global Locking Protocols

Real-time locking protocols employ progress mechanism(s) to ensure that resource-holding jobs are scheduled. These mechanisms are required to bound the duration of priority-inversion blocking (pi-blocking) for jobs sharing resources. Examples of such progress mechanisms include priority inheritance and priority donation. Unfortunately, some progress mechanisms can cause any job, including those that never request shared resources, to be blocked upon job release. This paper presents a variant of priority donation for globally-scheduled systems that only causes blocking for jobs waiting for shared resources. Additionally, this variant of priority donation is employed to construct a new suspension-based locking protocol called the replica-request donation global locking protocol (R2DGLP), which is asymptotically optimal for both mutex and k-exclusion (i.e., multi-unit) resources. This work is motivated by multicore systems where tasks may share I/O devices (e.g., GPUs) where critical sections can be long. In such applications, progress mechanisms that cause jobs that do not access I/O devices to be blocked to ensure progress can be detrimental from a schedulability perspective.
Breast Reconstruction with Free Tissue Transfer from the Abdomen in the Morbidly Obese

Background: There are national trends of increasing incidence of morbid obesity and autologous breast reconstruction with free tissue transfer from the abdomen. The purpose of this study was to assess the safety and efficacy of free flap breast reconstruction in the morbidly obese population. Methods: A retrospective review was conducted on all patients who underwent transverse rectus abdominis myocutaneous, deep inferior epigastric perforator, or superficial inferior epigastric artery flap breast reconstructions between July of 2006 and October of 2008. Data from all patients with a body mass index greater than 40 were compared with those of patients with a body mass index less than 40. A p value less than 0.05 was considered significant. Significant findings were then analyzed in a post hoc fashion to examine trends with increasing body mass index. Results: Four hundred four patients underwent 612 free flap breast reconstructions during the study period. Twenty-five of these patients (6 percent) had a body mass index greater than 40. The morbidly obese group had significantly higher rate of total flap loss (p = 0.02), total major postoperative complications (p = 0.05), and delayed wound healing (p = 0.006). Conclusions: Free flap breast reconstruction in the morbidly obese is associated with a higher risk of total flap loss, total major postoperative complications, and delayed abdominal wound healing. However, the overall incidence of complications is low, making free tissue transfer from the abdomen an acceptable method of breast reconstruction in this patient population.
Effects of lactoferrin-containing formula in the prevention of enterovirus and rotavirus infection and impact on serum cytokine levels: a randomized trial.

BACKGROUND Lactoferrin has been shown to exhibit anti-enterovirus 71 (EV71) and antirotavirus properties. This trial was conducted to determine whether a formula containing bovine lactoferrin (bLF) exerts a protective effect against EV71 or rotavirus infection among children from 2 to 6 years old. METHODS A prospective, randomized, single blind clinical trial of an oral supplement containing bLF (daily dose approximately 70 to 85 mg) was carried out with healthy children in a day care center from March 2002 to June 2003. The incidence of enterovirus or rotavirus infection and the serum level of interferon- gamma (IFN-γ) and interleukin-10 (IL-10) were compared between children receiving and not receiving bLF. RESULTS A total of 172 children, 96 in group A, which received bLF, and 76 in group B which did not receive bLF, completed the trial. During the study period, no EV71 was isolated and seroconversion of EV71 antibodies was noted in only one child. Fourteen episodes of presumptive enterovirus infection and 12 episodes of presumptive viral enteritis were detected. No significant differences were observed between groups in the incidence of presumptive enterovirus infection or viral enteritis or the number of laboratory confirmed enterovirus or rotavirus infections. No significant differences were observed in the serum levels of IFN-γ and IL-10 between groups either prior to or following the trial. In both groups, IFN-γ levels increased, but IL-10 was unchanged following the trial. CONCLUSION An oral supplement of bLF at a dose of 70 mg/day did not show any benefits in the prevention of EV71 or rotavirus infection, or any impact on IFN-γ or IL-10 serum levels in healthy children in this trial.
Active establishment of centromeric CENP-A chromatin by RSF complex

Centromeres are chromosomal structures required for equal DNA segregation to daughter cells, comprising specialized nucleosomes containing centromere protein A (CENP-A) histone, which provide the basis for centromeric chromatin assembly. Discovery of centromere protein components is progressing, but knowledge related to their establishment and maintenance remains limited. Previously, using anti-CENP-A native chromatin immunoprecipitation, we isolated the interphase–centromere complex (ICEN). Among ICEN components, subunits of the remodeling and spacing factor (RSF) complex, Rsf-1 and SNF2h proteins, were found. This paper describes the relationship of the RSF complex to centromere structure and function, demonstrating its requirement for maintenance of CENP-A at the centromeric core chromatin in HeLa cells. The RSF complex interacted with CENP-A chromatin in mid-G1. Rsf-1 depletion induced loss of centromeric CENP-A, and purified RSF complex reconstituted and spaced CENP-A nucleosomes in vitro. From these data, we propose the RSF complex as a new factor actively supporting the assembly of CENP-A chromatin.
Autophagy Is an Innate Mechanism Associated with Leprosy Polarization

Leprosy is a chronic infectious disease that may present different clinical forms according to the immune response of the host. Levels of IFN-γ are significantly raised in paucibacillary tuberculoid (T-lep) when compared with multibacillary lepromatous (L-lep) patients. IFN-γ primes macrophages for inflammatory activation and induces the autophagy antimicrobial mechanism. The involvement of autophagy in the immune response against Mycobacterium leprae remains unexplored. Here, we demonstrated by different autophagic assays that LC3-positive autophagosomes were predominantly observed in T-lep when compared with L-lep lesions and skin-derived macrophages. Accumulation of the autophagic receptors SQSTM1/p62 and NBR1, expression of lysosomal antimicrobial peptides and colocalization analysis of autolysosomes revealed an impairment of the autophagic flux in L-lep cells, which was restored by IFN-γ or rapamycin treatment. Autophagy PCR array gene-expression analysis revealed a significantly upregulation of autophagy genes (BECN1, GPSM3, ATG14, APOL1, and TPR) in T-lep cells. Furthermore, an upregulation of autophagy genes (TPR, GFI1B and GNAI3) as well as LC3 levels was observed in cells of L-lep patients that developed type 1 reaction (T1R) episodes, an acute inflammatory condition associated with increased IFN-γ levels. Finally, we observed increased BCL2 expression in L-lep cells that could be responsible for the blockage of BECN1-mediated autophagy. In addition, in vitro studies demonstrated that dead, but not live M. leprae can induce autophagy in primary and lineage human monocytes, and that live mycobacteria can reduce the autophagy activation triggered by dead mycobacteria, suggesting that M. leprae may hamper the autophagic machinery as an immune escape mechanism. Together, these results indicate that autophagy is an important innate mechanism associated with the M. leprae control in skin macrophages.
Understanding and managing knowledge loss

Purpose – Research on knowledge loss is at an early stage of evolution. This paper seeks to extend the existent literature through an exploratory investigation of the drivers and impacts of knowledge loss, as well as associated retention strategies within manufacturing and service operations. Design/methodology/approach – Multiple research streams are used to explore and capture the complexities and intricacies of knowledge loss within four firms. The author follows a multiple case study approach with theoretical sampling of manufacturing and service firms. Findings – The results of this study suggest that organizations should retain and diffuse architectural knowledge, improve strategic coordination among units, develop existing capabilities through different networking strategies and more effective networks, and transform these capabilities into effective organizational routines to mitigate knowledge loss and increase knowledge retention. Meanwhile, relying solely on standard operating procedures, infor.
A Kernel Test of Goodness of Fit

We propose a nonparametric statistical test for goodness-of-fit: given a set of samples, the test determines how likely it is that these were generated from a target density function. The measure of goodness-of-fit is a divergence constructed via Stein's method using functions from a Reproducing Kernel Hilbert Space. Our test statistic is based on an empirical estimate of this divergence, taking the form of a V-statistic in terms of the log gradients of the target density and the kernel. We derive a statistical test, both for i.i. d. and non-i.i. d. samples, where we estimate the null distribution quantiles using a wild bootstrap procedure. We apply our test to quantifying convergence of approximate Markov Chain Monte Carlo methods, statistical model criticism, and evaluating quality of fit vs model complexity in nonparametric density estimation.
CHARACTERIZATION OF THE MUCIN PHENOTYPE CAN PREDICT GASTRIC CANCER RECURRENCE AFTER ENDOSCOPIC MUCOSAL RESECTION.

BACKGROUND Endoscopic mucosal resection is still considered an accepted treatment for early gastric cancer for selected cases. Histopathologic criteria for curative endoscopic resection are intramucosal well-differentiated adenocarcinoma, lateral and deep margins free of tumor, no histological ulceration, and no venous or lymphatic embolism. A 5% local recurrence rate has been described even when all the above-mentioned criteria are met. On the other hand, antigen expression by tumoral cells has been related to the biological behavior of several tumors. OBJECTIVE To evaluate whether early gastric cancer mucin immunoexpression, p53 and Ki-67, can predict recurrence after endoscopic mucosal resection, even when standard histopathologic criteria for curative measures have been attempted. METHODS Twenty-two patients with early gastric cancer were considered to have been completely resected by endoscopic mucosal resection. Local recurrence occurred in 5/22 (22.7%). Immunohistochemical study was possible in 18 (81.8%) resected specimens. Patients were divided in two groups: those with and those without local recurrence. They were compared across demographic, endoscopic, histologic data, and immunohistochemical factors for MUC2, MUC5a, CD10, p53, and Ki-67. RESULTS Mucin immunoexpression allowed a reclassification of gastric adenocarcinoma in intestinal (10), gastric (2), mixed (4), and null phenotypes (2). Mixed phenotype (positive for both MUC2 and MUC5a) was found in 80% of cases in the local recurrence group, while the intestinal type (positive MUC2 and negative MUC5a) was found in 76.9% of cases without local recurrence (P=0.004). Other observed features did not correlate with neoplastic recurrence. CONCLUSION The mixed phenotype of early gastric adenocarcinoma is associated with a higher probability of local recurrence after endoscopic mucosal resection.