Miracle-dz/UniFAR-FTUs huggingface dataset:
Solving the Winner Determination Problem by a distributed genetic algorithm

In this paper we present a distributed system that is capable of solving the Winner Determination Problem (WDP) for combinatorial auctions by use of a genetic algorithm. Combinatorial auctions are simple, allowing agents to bid on combination of items rather than making several individual bids. These types of auctions lead to more economical efficient allocations of goods in situations where the agents' have preference over bundles of goods. However, determining the winner(s) has been shown to be a NP-complete problem. This means that there is no simple way to solving the WDP. Our approach is to use a distributed system that solves the WDP using a genetic algorithm that is being distributed. In this way we are able to take advantage of the benefits that distributed systems offer. The results obtained from the system are compared to IBM's algorithm, known as CPLEX.
Overexpression of Wip1 Is Associated with Biologic Behavior in Human Clear Cell Renal Cell Carcinoma

Wild-type p53-induced phosphatase (Wip1 or PPM1D) has been reported to be aberrantly expressed in various cancers and correlated with the malignant behavior of cancer cells. However, the function of Wip1 in RCC remains unclear. The present study investigated its abnormal expression and dysfunctions in clear cell renal cell carcinoma (ccRCC) in vitro. With the combination of immunohistochemistry, western blotting, immunofluorescence, qRT-PCR, and cell proliferation, migration and invasion assays, we found that levels of Wip1 mRNA and protein were dramatically increased in human ccRCC tissues (P<0.001 for both), and upregulation of Wip1 was significantly associated with depth of invasion (P<0.001), Distant metastasis (P = 0.001), lymph node status (P<0.001) and Fuhrman grade (P<0.001). Wip1 knockdown inhibited the proliferation, migration and invasion of 786-O and RLC-310 cells, whereas Wip1 overexpression promoted the growth and aggressive phenotype of 786-O and RLC-310 cells in vitro. The uni- and multivariate analyses indicated that expression of Wip1 was an independent predictor for survival of ccRCC patients (P = 0.003, P = 0.027 respectively). Wip1- negative patients had a higher tumor-free/overall survival rate than patients with high Wip1 expression (P = 0.001, P = 0.002 respectively). Overexpression of Wip1 is useful in the prediction of survival in ccRCC patients.
Version Detection For Historical Musical Automata

Musical automata were very popular in European homes in the pre-phonograph era, but have attracted little attention in academic research. Motivated by a specific application need, this paper proposes a first approach to the automatic detection of versions of the same piece of music played by different automata. Due to the characteristics of the instruments as well as the themes played, this task deviates considerably from cover version detection in modern pop and rock music. We therefore introduce an enhanced audio matching and comparison algorithm with two main features: (1) a new alignment cost measure – Off-Diagonal Cost – based on the Hough transform; and (2) a split-and-merge strategy that compensates for major structural differences between different versions. The system was evaluated on a test set comprising 89 recordings of historical musical automata. Results show that the new algorithm performs significantly better than the reference system based on Dynamic Time Warping and chroma features without the above-mentioned new features, and that it may work well enough to be practically useful for the intended application.
La prévention et la réduction des problèmes liés à la consommation de substances psychoactives par une intervention brève ciblée à la personnalité chez les adolescents présentant des problèmes de santé mentale

Background: In adolescents, mental health disorders frequently co-occurs with substance misuse, a dual diagnosis that tends to complicate the patient’s treatment and prognosis, resulting in astounding costs for society. Thus, it is critical to investigate how to prevent and reduce substance use problems in this population and optimize their global treatment. According to recent literature and to health provincial and federal governments’ priorities, an integrated services approach has been identified as the strategy to favour. In three randomised-controlled trials, brief personality-targeted interventions have shown to be effective in preventing adolescent onset and growth of drinking, binge-drinking and drinking problems. The personality profiles targeted (Hopelessness/Negative thinking, Impulsivity, Anxiety-Sensitivity, Sensation Seeking) play an important role in the onset and development of both substance misuse and psychiatric symptoms. In this thesis, we hypothesized that brief personality-targeted interventions aiming to prevent and reduce substance misuse in a high-risk population would also benefit a psychiatric clinical sample of adolescents. Methods: To test this hypothesis, 2 studies were conducted as part of this thesis. In the first one, data from an existing sample of adolescents from a school cohort were analysed to determine if among these students, those at high risk of alcohol misuse and presenting with psychiatric symptoms could benefit from this brief intervention. The same intervention was then delivered to a clinical sample of adolescents; this second study was conducted in a psychiatric department in a hospital setting. Results: The first study showed that the intervention was as effective regardless of whether the adolescents reported depression and anxiety symptoms; these symptoms did not moderate the intervention effects on substance misuse and associated problems. However, reporting hyperactivity/impulsivity symptoms and conduct problems did significantly moderate the intervention effects on some drinking outcomes, showing mainly more beneficial intervention effects in adolescents reporting higher levels of externalizing symptoms. In the second study, no significant intervention effects were found regarding substance use and psychiatric symptoms outcomes. Adolescents who
Motor Effort Alters Changes of Mind in Sensorimotor Decision Making

After committing to an action, a decision-maker can change their mind to revise the action. Such changes of mind can even occur when the stream of information that led to the action is curtailed at movement onset. This is explained by the time delays in sensory processing and motor planning which lead to a component at the end of the sensory stream that can only be processed after initiation. Such post-initiation processing can explain the pattern of changes of mind by asserting an accumulation of additional evidence to a criterion level, termed change-of-mind bound. Here we test the hypothesis that physical effort associated with the movement required to change one's mind affects the level of the change-of-mind bound and the time for post-initiation deliberation. We varied the effort required to change from one choice target to another in a reaching movement by varying the geometry of the choice targets or by applying a force field between the targets. We show that there is a reduction in the frequency of change of mind when the separation of the choice targets would require a larger excursion of the hand from the initial to the opposite choice. The reduction is best explained by an increase in the evidence required for changes of mind and a reduced time period of integration after the initial decision. Thus the criteria to revise an initial choice is sensitive to energetic costs.
Loop quantization of the polarized Gowdy model on T3: kinematical states and constraint operators

In this second paper on loop quantization of the Gowdy model, we introduce the kinematical Hilbert space on which appropriate holonomies and fluxes are well represented. The quantization of the volume operator and the Gauss constraint is straightforward. Imposition of the Gauss constraint can be done on the kinematical Hilbert space to select subspace of gauge-invariant states. We carry out the quantization of the Hamiltonian constraint making specific choices. Alternative choices are briefly discussed. It appears that to get spatial correlations reflected in the Hamiltonian constraint, one may have to adopt the so-called effective operator viewpoint.
Improved Surface Photometric Mapping Across Gusev and Apollinaris from an HRSC/Mars Express Integrated Multi-Orbit Dataset: Implication on Hapke Parameters Determination

HRSC/ MARS EXPRESS INTEGRATED MULTI-ORBIT DATASET: IMPLICATION ON HAPKE PARAMETERS DETERMINATION. A. Jehl, P. C. Pinet, A. Cord, Y.D. Daydou, D. Baratoux, S.C. Chevrel, N. Manaud, R. Greeley, M.A. Kreslavsky, J. Raitala, H. Hoffmann, K. Gwinner, F. Scholten, T. Roatsch, R. Jaumann, G. Neukum, and The Mars Express HRSC Co-Investigator Team. UMR 5562 / CNRS / GRGS, Observatoire Midi-Pyrénées, Toulouse, France, European Space Agency (ESA), European Space & Technology Centre (ESTEC), P.O. Box 299, 2200 AG Noordwijk, The Netherlands, Department of Geological Sciences, Arizona State University, Box 871404, Tempe AZ 85287-1404, Brown University, Providence, USA ; Institute of Radiophysics, Kharkov, Ukraine ; Astronomy Division, University of Oulu, Oulu, Finland Freie Universitaet Berlin, Department of Earth Sciences, Malteserstr. 74-100 Building D, D-12249 Berlin Germany.
Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia

Background During acute infection and inflammation, dramatic shifts in tissue metabolism are typical, thereby resulting in profound tissue hypoxia. Therefore, we pursued the hypothesis, that tissue hypoxia may influence innate immune responses by transcriptional modulation of Toll-like receptor (TLRs) expression and function. Methodology/Principal Findings We gained first insight from transcriptional profiling of murine dendritic cells exposed to hypoxia (2% oxygen for 24 h). While transcript levels of other TLRs remained unchanged, we found a robust induction of TLR2 (2.36±0.7-fold; P<0.05) and TLR6 (3.46±1.56-fold; P<0.05). Additional studies in different cells types and cell-lines including human dendritic cells, monocytic cells (MM6), endothelia (HMEC-1) or intestinal epithelia (Caco-2) confirmed TLR2 and TLR6 induction of transcript, protein and function during hypoxia. Furthermore, analysis of the putative TLR2 and TLR6 promoters revealed previously unrecognized binding sites for HIF-1, which were shown by chromatin immunoprecipitation to bind the pivotal hypoxia-regulating transcription factor HIF-1alpha. Studies using loss and gain of function of HIF-1 confirmed a critical role of HIF-1alpha in coordinating TLR2 and TLR6 induction. Moreover, studies of murine hypoxia (8% oxygen over 6 h) showed TLR2 and TLR 6 induction in mucosal organs in vivo. In contrast, hypoxia induction of TLR2 and TLR6 was abolished in conditional HIF-1α mutant mice. Conclusions/Significance Taking together, these studies reveal coordinated induction of TLR2 and TLR6 during hypoxia and suggest tissue hypoxia in transcriptional adaptation of innate immune responses during acute infection or inflammation.
Epidemiology of Transfusion Transmitted Infection among Patients with β-Thalassaemia Major in Pakistan

Introduction. Transfusion Transmitted Infections (TTIs) continue to be a major risk in transfusions in many parts of the world. The transfusion-dependent β-thalassaemia patients are particularly at risk of acquiring TTIs. The current study was undertaken to estimate the prevalence of TTIs in transfusion-dependent β-thalassaemia patients. Material and Methods. A cross-sectional study of 1253 multitransfused thalassaemia major patients was conducted in five different centres of Islamabad, Rawalpindi, and Karachi. The study subjects were screened for HIV, HCV, and HBV. The screening was performed at two centres: Department of Pathology, Shaheed Zulfiqar Ali Bhutto (SZAB) Medical University, and Blood Transfusion Services, Jinnah Postgraduate Medical Centre, from July to December 2015. The confirmatory screening was performed by Chemiluminescent Immunoassay (CLIA). Results. Out of the 1253 multiple transfused patients, 317 (25.3%) were infected with TTIs. HCV was positive in 273 cases (21.7%), HBV in 38 cases (3.0%), and HIV in 6 cases (0.5%). Conclusion. HCV was the leading TTI in multitransfused thalassaemia major patients in the study. Presence of HIV in thalassaemia patients is a recent disturbing development in Pakistan. Improved regulation of blood banks including use of internationally or nationally evaluated kits will bring down the incidence of TTIs in transfusion-dependent β-thalassaemia patients. More stringent behavioral and serological pretransfusion screening of blood for TTIs must be implemented in blood banks.
Patterns of Participation and Social Connections in Online Discussion Forums

Social relations are an essential component of group learning online, because through them, the process is managed and controlled. In addition, learning cannot be understood in isolation from its situated nature. To identify patterns of participation and social connections in online group learning, this study analyzes the social network among university students who work in online discussion forums and are required to solve higher order learning tasks. Discussion forums were used, focusing on three types of tasks: analyzing case studies, evaluating websites, and creating WebQuest. The structures of social networks that arose out of 96 discussion forums over three academic years were analyzed. The results demonstrate that as the opening (lower level of structuration) of the learning task increases, so too does the need for social interaction in the group. The social structure of the groups is modulated by the type of learning task. Finally, the educational implications of the results are discussed.
COLA. II. Radio and Spectroscopic Diagnostics of Nuclear Activity in Galaxies

We present optical spectroscopic observations of 93 galaxies taken from the infrared-selected COLA (compact objects in low-power AGNs) sample. These are all galaxies for which we have previously obtained low-resolution radio observations and high-resolution (<0.″05) Australian Long Baseline Array snapshots. The sample spans the range of far-IR luminosities from normal galaxies to luminous infrared galaxies and contains a significant number of galaxies involved in galaxy-galaxy interactions. Of the galaxies observed, 78 (84%) exhibit emission lines indicating that they are either AGNs or actively forming stars (starburst galaxies). Using a newly developed, theoretically based, optical emission line scheme to classify the spectra, we find that 15% of the emission-line galaxies are Seyfert galaxies, 77% are starbursts, and the rest are either borderline AGN/starburst or show ambiguous characteristics. We find little evidence for an increase in the fraction of AGNs in the sample as a function of far-IR (FIR) luminosity, in contrast to previous studies, but our sample covers only a small range in infrared luminosity (1010.5 L☉ ≤ LFIR ≤ 1011.7 L☉), and thus a weak trend may be masked. Instead, as the infrared luminosity increases, so does the fraction of metal-rich starbursts, objects that on more traditional diagnostic diagrams would have been classified as weak, low-ionization, narrow emission line regions. As a whole the Seyfert galaxies exhibit a small, but statistically significant, radio excess on the radio-FIR correlation compared to the galaxies classified as starbursts. Compact (<0.″05) radio cores are detected in 55% of the Seyfert galaxies, and these galaxies exhibit a significantly larger radio excess than the Seyfert galaxies in which compact cores were not detected. Our results indicate that there may be two distinct populations of Seyfert galaxies, "radio-excess" Seyfert galaxies, which exhibit extended radio structures and compact radio cores, and "radio-quiet" Seyfert galaxies, in which the majority of the radio emission can be attributed to star formation in the host galaxy. No significant difference is seen between the IR and optical spectroscopic properties of Seyfert galaxies with and without radio cores.
Using Gaussian Measures for Efficient Constraint Based Clustering

In this paper we present a novel iterative multiphase clustering technique for efficiently clustering high dimensional data points. For this purpose we implement clustering feature (CF) tree on a real data set and a Gaussian density distribution constraint on the resultant CF tree. The post processing by the application of Gaussian density distribution function on the micro-clusters leads to refinement of the previously formed clusters thus improving their quality. This algorithm also succeeds in overcoming the inherent drawbacks of conventional hierarchical methods of clustering like inability to undo the change made to the dendogram of the data points. Moreover, the constraint measure applied in the algorithm makes this clustering technique suitable for need driven data analysis. We provide veracity of our claim by evaluating our algorithm with other similar clustering algorithms. Introduction
Recent advances: Consumer health informatics

http://bmj.com/cgi/content/full/320/7251/1713 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/320/7251/1713/DC1 "Additional information" References http://bmj.com/cgi/content/full/320/7251/1713#otherarticles 19 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/320/7251/1713#BIBL This article cites 24 articles, 18 of which can be accessed free at:
Personality Types Classification for Indonesian Text in Partners Searching Website Using Naïve Bayes Methods

The development of digital text information has been growing fast, but most of digital text is in unstructured form. Text mining analysis is needed in dealing with such unstructured text. One of the activities important in text mining is text classification or categorization. Text categorization itself currently has a variety of approaches such as probabilistic approaches, support vector machines, and artificial neural network or decision tree classification. Naive Bayes probabilistic method has several advantages of simplicity in computing. Naive Bayes method is a good method in machine learning based on training data using conditional probability as the basic. This experiments use text mining with Naive Bayes method to classify the personality type of user and use the type to find their couples based on the compatibility of their personality type.
Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome-wide association and polygenic scoring study

Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is independent of other psychiatric disorders. Genome‐wide association studies (GWAS) on suicide attempt (SA) and ideation have failed to identify specific genetic variants. Here, we conduct further GWAS and for the first time, use polygenic score analysis in cohorts of patients with mood disorders, to test for common genetic variants for mood disorders and suicide phenotypes. Genome‐wide studies for SA were conducted in the RADIANT and GSK‐Munich recurrent depression samples and London Bipolar Affective Disorder Case‐Control Study (BACCs) then meta‐analysis was performed. A GWAS on suicidal ideation during antidepressant treatment had previously been conducted in the Genome Based Therapeutic Drugs for Depression (GENDEP) study. We derived polygenic scores from each sample and tested their ability to predict SA in the mood disorder cohorts or ideation status in the GENDEP study. Polygenic scores for major depressive disorder, bipolar disorder and schizophrenia from the Psychiatric Genomics Consortium were used to investigate pleiotropy between psychiatric disorders and suicide phenotypes. No significant evidence for association was detected at any SNP in GWAS or meta‐analysis. Polygenic scores for major depressive disorder significantly predicted suicidal ideation in the GENDEP pharmacogenetics study and also predicted SA in a combined validation dataset. Polygenic scores for SA showed no predictive ability for suicidal ideation. Polygenic score analysis suggests pleiotropy between psychiatric disorders and suicidal ideation whereas the tendency to act on such thoughts may have a partially independent genetic diathesis. © 2014 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals, Inc.
Deviant Behaviour in English and West Indian Schoolchildren

The Department of Education defines an immigrant child as 'A child born outside the British Isles to parents whose countries of origin were abroad; and children born in this country but whose parents have been here for less than ten years. ' 1 In I969 the total number of immigrant children so defined was, in maintained primary and secondary schools in England and Wales, 249,664, or 3 ·2 per cent of all pupils. Of the immigrant pupils 106,I26 came from the West Indies, (including Guyana), and children of West Indian origin form the largest single group of immigrant school children (DES, I970). The background to the migration and settlement of this group is given in detail by Rose et. al. (I969). A num her of clinical studies of psychiatric disorder in West Indian children have been carried out. Graham and Meadows (I967) investigated fifty-five West Indian children, and matched English-born controls, referred to the Brixton Child Guidance Clinic over a three-year period. Twenty-nine of the subjects were boys (mean age 9 · I) and twenty-six were girls (mean age 9 · 6 years). The West Indian children represented 9 · 5 per cent of the clinic population. No control group of normal West Indian children was studied. The West Indian group contained proportionately more girls than the clinic population as a whole, and this sex difference was taken into account in selecting clinic controls. No differences between West Indian children and controls were found with respect to domestic circumstances (including absence of parents from home). However, significantly more of the West Indian girls than controls had experienced earlier maternal separation, and both West Indian girls and boys had experienced significantly more paternal separation than controls. The study and control children were not matched for diagnosis, and a comparison of symptom patterns indicated that significantly more of both West Indian boys and girls were disobedient in the school setting. The West Indian girls were significantly less