Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical supervision: what do we know and what do we need to know? A review and commentary.

AIMS This study is addressed to nurses but the issues are of equal concern to both midwives and health visitors. Clinical supervision ideally both challenges nurses as well as help their practice. There is need to identify critical elements that help professional practice and understand more clearly the changing nature of supervisory relationships. BACKGROUND Clinical supervision in nursing is over a decade old in the UK and yet emerging nursing literature suggests that many ideas remain unfamiliar to nursing practice. The resistance shown by nurse towards clinical supervising remains perplexing. Moreover, ideas concerning clinical supervision have been applied without a substantive evidence base. METHODS The discussion draws on varied ideas concerning supervision, including those outside of nursing, to ask what do we know and still need to know about clinical supervision. This study suggests that, a single approach to clinical supervision could be unhelpful to nursing. FINDINGS AND CONCLUSION Nursing knowledge concerning many aspects of clinical supervision is increasing because of research. Much of the literature suggests that clinical supervision is scholarly activity requiring much the same attention to relationships as the therapeutic activities it supports. This discussion concludes with the idea that clinical supervision might work at its best as a quiet activity allowing nurses to think about nursing work in ways that suit individual learning styles.
Linking environmental variability and fish performance: integration through the concept of scope for activity

Investigating the biological mechanisms linking environmental variability to fish production systems requires the disentangling of the interactions between habitat, environmental adaptation and fitness. Since the number of environmental variables and regulatory processes is large, straightening out the environmental influences on fish performance is intractable unless the mechanistic analysis of the ‘fish-milieu’ system is preceded by an understanding of the properties of that system. While revisiting the key points in our currently poorly integrated understanding of fish ecophysiology, we have highlighted the explanatory potential contained within Fry's (Fry 1947 Univ. Toronto Stud. Biol. Ser. 55, 1–62) concept of metabolic scope and categorization of environmental factors. These two notions constitute a pair of powerful tools for conducting an external (at the emerging property level) analysis of the environmental influences on fish, as well as an internal (mechanistic) examination of the behavioural, morphological and physiological processes involved. Using examples from our own and others work, we have tried to demonstrate that Fry's framework represents a valuable conceptual basis leading to a broad range of testable ecophysiological hypotheses.
On stability of hyperbolic thermoelastic Reissner–Mindlin–Timoshenko plates

In the present article, we consider a thermoelastic plate of Reissner–Mindlin–Timoshenko type with the hyperbolic heat conduction arising from Cattaneo's law. In the absence of any additional mechanical dissipations, the system is often not even strongly stable unless restricted to the rotationally symmetric case, and so on. We present a well‐posedness result for the linear problem under general mixed boundary conditions for the elastic and thermal parts. For the case of a clamped, thermally isolated plate, we show an exponential energy decay rate under a full damping for all elastic variables. Restricting the problem to the rotationally symmetric case, we further prove that a single frictional damping merely for the bending component is sufficient for exponential stability. To this end, we construct a Lyapunov functional incorporating the Bogovskiĭ operator for irrotational vector fields, which we discuss in the appendix. Copyright © 2014 John Wiley & Sons, Ltd.
Effects of soybean isoflavone on intestinal antioxidant capacity and cytokines in young piglets fed oxidized fish oil

To investigate the effect of glycitein, a synthetic soybean isoflavone (ISF), on the intestinal antioxidant capacity, morphology, and cytokine content in young piglets fed oxidized fish oil, 72 4-d-old male piglets were assigned to three treatments. The control group was fed a basal diet containing fresh fish oil, and the other two groups received the same diet except for the substitution with the same dosage of oxidized fish oil alone or with ISF (oxidized fish oil plus ISF). After 21 d of feeding, supplementation of oxidized fish oil increased the levels of malondialdehyde (MDA), oxidized glutathione (GSSG), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), nuclear factor κ B (NF-κB), inducible nitric oxide synthase (iNOS), NO, and Caspase-3 in jejunal mucosa, and decreased the villous height in duodenum and the levels of secretory immunoglobulin A (sIgA) and IL-4 in the jejunal mucosa compared with supplementation with fresh oil. The addition of oxidized fish oil plus ISF partially alleviated this negative effect. The addition of oxidized fish oil plus ISF increased the villous height and levels of sIgA and IL-4 in jejunal mucosa, but decreased the levels of IL-1β and IL-2 in jejunal mucosa (P<0.05) compared with oxidized fish oil. Collectively, these results show that dietary supplementation of ISF could partly alleviate the negative effect of oxidized fish oil by improving the intestinal morphology as well as the antioxidant capacity and immune function in young piglets. 中文概要目 的研究大豆异黄酮对氧化鱼油造成仔猪氧化应激的 缓解作用, 并初步探讨其作用机制。 创新点首次在仔猪肠道氧化应激模型中证明大豆异黄酮 可缓解仔猪氧化应激, 且此作用与提高其免疫功 能相关。 方 法将72 头平均体重约1. 8 kg 的4 日龄杜×(长×大) 三元杂公猪随机分为3 组, 每组重复6 次, 每次 重复包括4头猪: 对照组(饲喂50 g/kg新鲜鱼油), 处理组1(添加50 g/kg 氧化鱼油)和处理组2(添 加50 g/kg 氧化鱼油+20 mg/kg 大豆异黄酮); 基础日粮根据NRC(2012)《猪的营养需要量》配 制, 每3 小时饲喂一次, 记录每天采食量; 实验 期21 天结束后, 称重, 计算平均日采食量、平 均日增重及料重比。 用苏木精-伊红染色法观察 小肠形态结构, 并计算绒毛高度和隐窝深度, 应 用南京建成试剂盒测定肠道中抗氧化酶的活性, 应用酶联免疫吸附测定(ELISA)试剂盒测定细 胞炎症相关因子和细胞凋亡相关因子的表达。 结 论饲喂氧化鱼油引起新生仔猪肠道产生氧化应激, 引起仔猪生长性能下降、肠道发育受损、细胞凋 亡增加及免疫功能失调。 而添加大豆异黄酮能减 缓氧化鱼油造成的肠道损伤, 提高肠道粘膜完整 性, 提高肠道粘膜细胞抗氧化功能和免疫功能。
Influence of exercise and restricted activity on the protein composition of skeletal muscle.

Bandurski, R. S. & Axelrod, B. (1951). J. biol. Chem. 193, 405. Bovarnick, M. R. , Lindsay, A. & Hellerman, L. (1946). J. biol. Chem. 163, 523. Bowman, I. B. R. , Grant, P. T. & Kermack, W. 0. (1960). Exp. Para8it. 9, 131. Bowmani, I. B. R. , Grant, P. T. , Kermack, W. 0. & Ogston, D. (1959). Biochem. J. 73, 42P. Bueding, E. (1959). J. Pharm. , Lond. , 11, 392. Carles, J., Schneider, A. & Lacoste, A. (1958). Bull. Soc. Chim. biol., Pari8, 40, 221. Claycomb, C. K. , Hutchens, T. T. & van Bruggen, J. T. (1950). Nucleonics, 7, 38. Crane, R. K. & Sols, A. (1953). J. biol. Chem. 203, 273. Fraser, D. M. & Kermack, W. 0. (1957). Brit. J. Pharmacol. 12, 16. Fulton, J. D. & Grant, P. T. (1956). Biochem. J. 63, 274. Fulton, J. D. & Spooner, D. F. (1956). Exp. Parasit. 5, 59. Jones, A. R. , Dowling, E. J. & Skraba, W. J. (1953). Analyt. Chem. 25, 394. Jones, E. S. , Maegraith, B. G. & Gibson, Q. H. (1953). Ann. trop. Med. Para8it. 47, 431. Khym, J. K. & Cohn, W. E. (1953). J. Amer. chem. Soc. 75, 1153. Krebs, H. A. & Eggleston, L. V. (1940). Biochem. J. 84, 442. Lohmann, K. (1933). Biochem. Z. 262, 137. McKee, R. W. (1951). In Biochemi8try and Phyaiology of Protozoa, vol. 1, p. 252. Ed. by Lwoff, A. New York: Academic Press Inc. Mansour, T. E. & Bueding, E. (1954). Brit. J. Pharmacol. 9, 459. Marshall, P. B. (1948). Brit. J. Pharmacol. 3, 1. Moulder, J. W. (1948). J. infect. Die. 83, 262. Moulder, J. W. (1949). J. infect. Di8. 85, 195. Nelson, N. (1944). J. biol. Chem. 153, 375. Phares, E. F. , Mosbach, E. H. , Denison, F. W. & Carson, S. F. (1952). Analyt. Chem. 24, 660. Pirie, N. W. (1946). Biochem. J. 40, 100. Popjak, G. (1950). Biochem. J. 46, 560. Sakami, W. (1955). Handbook of l8otopic Tracer Method8. Cleveland: Western Reserve University. Shreeve, W. W. , Leaver, F. & Siegel, I. (1952). J. Amer. chem. Soc. 74, 2404. Somogyi, M. (1952). J. biol. Chem. 195, 19. Speck, J. F. & Evans, E. A. (1945a). J. biol. Chem. 159, 71. Speck, J. F. & Evans, E. A. (1945b). J. biol. Chem. 159, 83. Speck, J. F. , Moulder, J. W. & Evans, E. A. (1946). J. biol. Chem. 164, 119. van Slyke, D. D. & Folch, J. (1940). J. biol. Chem. 138, 509. Weil-Malherbe, J. & Bone, A. D. (1951). Biochem. J. 49, 339.
Strong scaling and speedup to 16,384 processors in cardiac electro — Mechanical simulations

High performance computing is required to make feasible simulations of whole organ models of the heart with biophysically detailed cellular models in a clinical setting. Increasing model detail by simulating electrophysiology and mechanical models increases computation demands. We present scaling results of an electro — mechanical cardiac model of two ventricles and compare them to our previously published results using an electrophysiological model only. The anatomical data-set was given by both ventricles of the Visible Female data-set in a 0.2 mm resolution. Fiber orientation was included. Data decomposition for the distribution onto the distributed memory system was carried out by orthogonal recursive bisection. Load weight ratios for non — tissue vs. tissue elements used in the data decomposition were 1:1, 1:2, 1:5, 1:10, 1:25, 1:38.85, 1:50 and 1:100. The ten Tusscher et al. (2004) electrophysiological cell model was used and the Rice et al. (1999) model for the computation of the calcium transient dependent force. Scaling results for 512, 1024, 2048, 4096, 8192 and 16,384 processors were obtained for 1 ms simulation time. The simulations were carried out on an IBM Blue Gene/L supercomputer. The results show linear scaling from 512 to 16,384 processors with speedup factors between 1.82 and 2.14 between partitions. The most optimal load ratio was 1:25 for on all partitions. However, a shift towards load ratios with higher weight for the tissue elements can be recognized as can be expected when adding computational complexity to the model while keeping the same communication setup. This work demonstrates that it is potentially possible to run simulations of 0.5 s using the presented electro-mechanical cardiac model within 1.5 hours.
Developmental changes in effective connectivity associated with relational reasoning

Rostrolateral prefrontal cortex (RLPFC) is part of a frontoparietal network of regions involved in relational reasoning, the mental process of working with relationships between multiple mental representations. RLPFC has shown functional and structural changes with age, with increasing specificity of left RLPFC activation for relational integration during development. Here, we used dynamic causal modeling (DCM) to investigate changes in effective connectivity during a relational reasoning task through the transition from adolescence into adulthood. We examined fMRI data of 37 healthy female participants (11–30 years old) performing a relational reasoning paradigm. Comparing relational integration to the manipulation of single relations revealed activation in five regions: the RLPFC, anterior insula, dorsolateral PFC, inferior parietal lobe, and medial superior frontal gyrus. We used a new exhaustive search approach and identified a full DCM model, which included all reciprocal connections between the five clusters in the left hemisphere, as the optimal model. In line with previous resting state fMRI results, we showed distinct developmental effects on the strength of long‐range frontoparietal versus frontoinsular short‐range fixed connections. The modulatory connections associated with relational integration increased with age. Gray matter volume in left RLPFC, which decreased with age, partly accounted for changes in fixed PFC connectivity. Finally, improvements in relational integration performance were associated with greater modulatory and weaker fixed PFC connectivity. This pattern provides further evidence of increasing specificity of left PFC function for relational integration compared to the manipulation of single relations, and demonstrates an association between effective connectivity and performance during development. Hum Brain Mapp 35:3262–3276, 2014. © 2013 Wiley Periodicals, Inc.
Comprehensive Approach to Coregistration of Autoradiography and Microscopy Images Acquired from a Set of Sequential Tissue Sections

Histopathologic validation of a PET tracer requires assessment of colocalization of the tracer with its intended biologic target. Using thin tissue section autoradiography, it is possible to visualize the spatial distribution of the PET tracer uptake and compare it with the distribution of the intended biologic target (as visualized with immunohistochemistry). The purpose of this study was to develop and evaluate an objective methodology for deformable coregistration of autoradiography and microscopy images acquired from a set of sequential tissue sections. Methods: Tumor-bearing animals were injected with 3′-deoxy-3′-18F-fluorothymidine (18F-FLT), 14C-FDG, and other markers of tumor microenvironment including Hoechst 33342 (blood-flow surrogate). After sacrifice, tumors were excised, frozen, and sectioned. Multiple stacks of sequential 8 μm sections were collected from each tumor. From each stack, the middle (reference) sections were used to obtain images of 18F-FLT and 14C-FDG uptake distributions using dual-tracer autoradiography. Sections adjacent to the reference were used to acquire all histopathologic data (e.g., images of cell proliferation, hematoxylin and eosin). Hoechst images were acquired from all sections. To correct for deformations and misalignments induced by tissue processing and image acquisition, the Hoechst image of each nonreference section was deformably registered to the reference Hoechst image. This transformation was then applied to all images acquired from the same tissue section. In this way, all microscopy images were registered to the reference Hoechst image. The Hoechst-to-autoradiography image registration was done using rigid point-set registration based on external markers visible in both images. Results: The mean error of Hoechst to 18F-FLT autoradiography registration (both images acquired from the same section) was 30.8 ± 20.1 μm. The error of Hoechst-based deformable registration of histopathologic images (acquired from sequential tissue sections) was 23.1 ± 17.9 μm. Total error of registration of autoradiography images to the histopathologic images acquired from adjacent sections was evaluated at 44.9 μm. This coregistration precision supersedes current rigid registration methods with reported errors of 100–200 μm. Conclusion: Deformable registration of autoradiography and histopathology images acquired from sequential sections is feasible and accurate when performed using corresponding Hoechst images.
Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

TNF plays a crucial role in the pathogenesis of Crohn disease. Dysregulated TNF production in mice that bear the genetic deletion of the TNF AU-rich regulatory elements (ARE) (TnfΔARE/+ mice) results in TNF receptor I (TNFRI)-dependent spontaneous Crohn-like pathology. Current concepts consider intestinal epithelial cell (IEC) responses to TNF to be critical for intestinal pathology, but the potential contribution of IEC-derived TNF in disease pathogenesis has not been addressed. In this study we examined whether IEC are sufficient as cellular targets or sources of TNF in the development of intestinal pathology. Using IEC-specific reactivation of a hypomorphic TnfΔAREneo allele in mice, we show that selective chronic overproduction of TNF by IEC suffices to cause full development of Crohn-like pathology. Epithelial TNF overexpression leads to early activation of the underlying intestinal myofibroblast, a cell type previously identified as a sufficient target of TNF for disease development in the TnfΔARE model. By contrast, restricted TNFRI expression on IEC although sufficient to confer IEC apoptosis after acute exogenous TNF administration, fails to induce pathology following chronic specific targeting of IEC by endogenous TNF in TnfΔARE/+ mice. Our results argue against IEC being early and sufficient responders to chronic TNF-mediated pathogenic signals and suggest that proinflammatory aberrations leading to chronic TNF production by IEC may initiate pathology in Crohn disease.
Dental Caries in Pre–School Children: Associations with Social Class, Toothbrushing Habit and Consumption of Sugars and Sugar–Containing Foods

This project examined the relative significance of dietary sugars, toothbrushing frequency and social class as predictors of caries experience (caries vs. no caries) among 1,450 British pre–school children who took part in the National Diet and Nutrition Survey. This cross–sectional survey was based on a representative sample of children aged 1.5–4.5 years studied in 1992/3. Children were classified into four groups according to social class and toothbrushing habit. Diet/caries associations were examined for biscuits and cakes, sugar confectionery, chocolate confectionery and soft drinks, and the percentage of energy from non–milk extrinsic sugars, using data on amount and frequency of consumption from 4–day weighed dietary records. In stepwise logistic regressions, the strength of the association between social class and caries experience was twice that between toothbrushing and caries, and nearly three times that between sugar confectionery and caries (other dietary variables were not significant). The association of caries with sugar confectionery (both in amount and frequency) was only present among children whose teeth were brushed less than twice a day. Toothbrushing frequency appeared to have a stronger impact on caries prevention in non–manual compared with manual children. Household expenditure on confectionery was associated with caries only among children from the manual group. The findings suggest the hypothesis that regular brushing (twice a day) with a fluoride toothpaste may have greater impact on caries in young children than restricting sugary foods.
Using Past Speaker Behavior to Better Predict Turn Transitions

This paper explores using a summary of past speaker behavior to better predict turn transitions. We computed two types of summary features that represent the current speaker’s past turn-taking behavior: relative turn length and relative floor control. Relative turn length measures the current turn length so far (in time and words) relative to the speaker’s average turn length. Relative floor control measures the speaker’s control of the conversation floor (in time and words) relative to the total conversation length. The features are recomputed for each dialog act based on past turns of the speaker within the current conversation. Using the switchboard corpus, we trained two models to predict turn transitions: one with just local features (e.g., current speech act, previous speech act) and one that added the summary features. Our results shows that using the summary features improve turn transitions prediction.
Peritransplant Injury to the Myocardium Associated with the Development of Accelerated Arteriosclerosis in Heart Transplant Recipients

Accelerated arteriosclerosis is now the major long-term complication of heart transplantation. Defining the risk factors associated with the development of accelerated arteriosclerosis will provide not only a means of identifying patients at risk for this complication but also clues to the etiology of accelerated arteriosclerosis. The purpose of this study was to examine the relationship between peritransplant myocardial ischemic injury and the development of accelerated arteriosclerosis. In a case-control study we examined the first three endomyocardial biopsies from 50 heart transplant recipients and graded the degree of ischemic injury present in these biopsies. The histologic changes graded in the biopsies included contraction band necrosis, coagulative necrosis, and macro-phagic removal of ischemically injured myocytes. Of the 50 recipients included in the study, 25 had angiographic evidence of accelerated arteriosclerosis and 25 did not. In multivariate analysis, which included the number of class I major histocompatibility (MHC) antigen mismatches between the donor and the recipient, the recipient's post-transplant cytomegalovirus status, the donor's age, and the number of rejection episodes, the histologic degree of ischemic injury present in the biopsies emerged as the strongest predictor of the development of accelerated arteriosclerosis (RR 2.6, 95% CI 1.2–5.8, p = 0.02). These results suggest that ischemic injury to the heart during the peritransplant period significantly contributes to the development of accelerated arteriosclerosis in heart transplant recipients and that histologic changes in early post-transplant biopsies can be used to identify recipients at risk of developing acclerated arteriosclerosis.
Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis

The production of nitric oxide by the inflammatory isoform of nitric oxide synthase (NOS2) in brain glial cells is thought to contribute to the causes and development of neurological diseases and trauma. We previously demonstrated that activation of a heat shock response (HSR) by hyperthermia reduced NOS2 expression in vitro, and in vivo attenuated the clinical and histological symptoms of the demyelinating disease experimental autoimmune encephalomyelitis (EAE; Heneka et al. [2001] J. Neurochem. 77:568–579). Benzoquinoid ansamycins are fungal‐derived antibiotics with tyrosine kinase inhibitory properties, and which also induce a HSR by allowing activation of HS transcription factor HSF1. We now show that two members of this class of drugs (geldanamycin and 17‐allylamino‐17‐demethoxygeldanamycin) also induce a HSR in primary rat astrocytes and rat C6 glioma cells. Both drugs dose‐dependently reduced nitrite accumulation, NOS2 steady‐state mRNA levels, and the cytokine‐dependent activation of a rat 2.2‐kB NOS2 promoter construct stably expressed in C6 cells. These inhibitory effects were partially reversed by quercetin, a bioflavonoid which prevents HSF1 binding to DNA and thus attenuates the HSR. Ansamycins increased mRNA levels of the inhibitory IκBα protein, suggesting that inhibition of NFκB activation could contribute to their suppressive effects. Finally, in C57BL/6 mice actively immunized to develop EAE, a single injection of geldanamycin at 3 days after immunization reduced disease onset by over 50%. These results indicate that ansamycins can exert potent anti‐inflammatory effects on brain glial cells which may provide therapeutic benefit in neuroinflammatory diseases. © 2002 Wiley‐Liss, Inc.
Monoclonal antibody therapy of leukaemias and lymphomas

Paul Erhlich conceived of antibody-based immunotherapy in the nineteenth century. Rituximab, which is a chimeric monoclonal antibody produced by recombinant technology, became the first monoclonal antibody to be approved for haematological malignancies by the US Food and Drug Administration. Subsequently, radiolabelling technologies have made it possible to chelate radioactive isotopes to monoclonal antibodies, which retain their specificity and take advantage of targeted delivery of localised radiation. Radioimmunoconjugates are an attractive therapeutic option for lymphomas due to the inherent sensitivity to radiotherapy, the fact that the local emission of ionising radiation by radiolabelled antibodies may kill cells with or without the target antigen in close proximity to the bound antibody, and penetrating radiation may obviate the problem of limited antibody penetration into bulky, poorly vascularised tumours. This paper reviews rituximab, alemtuzumab and gemtuzumab ozogamicin as monoclonal antibody therapies for leukaemias and lymphomas.