Miracle-dz/UniFAR-FTUs huggingface dataset:
Oral Clefts and Syndromic Forms of Tooth Agenesis as Models for Genetics of Isolated Tooth Agenesis

Genetic defects responsible for tooth agenesis are only now beginning to be uncovered. MSX1 and PAX9 have been associated with tooth agenesis in mice and humans, but interestingly for humans, these genes are associated with specific missing teeth. Mouse models also show that specific genes contribute to the development of specific types of teeth. A precise description of the phenotype specifying which teeth are missing has become fundamental. Mendelian segregation can be identified in families with tooth agenesis, but heterogenous or multiple genes may be responsible for the development of specific types of teeth agenesis in humans. Data from animal models are still very complex, and the human embryology is still poorly understood. Oral clefts and syndromic forms of tooth agenesis may be the best models for isolated tooth agenesis. In the future, a precise description of the missing teeth in syndromes involving tooth agenesis may be useful.
Management of Sucking Pest of Tomato

Tomato (Solanum lycopersicon L.) is one of the most popular and widely grown solanaceous crop in many countries including India. The estimated area under tomato in India is about 80.85 lakh ha with a production of 19.69 lakh tonnes and productivity 24.4 MT/ha of fruits (Anonymous, 2016-17). The tomato agro-ecosystem is characterized by having few major key pests and some minor or secondary pests. Tomato growers in Maharashtra regularly experienced the economic damage caused tomato fruit borer (Helicoverpa armigera Hubner), leaf miner (Liriomyza trifolii Blanchard), thrips (Thrips tabaci L.), white flies (Bemisia tabaci Gennadius), cutworm (Agrotis ipsilon Root), leaf eating caterpillar (Spodoptera litura Fabr.), aphid (Aphis gossypii Glov.), mealy bug (Ferrisia virgata Kill) and mites (Tetranychus sp.). Among the insect pests; sucking pests viz. thrips, whitefly and aphid do cause severe damage to crop by transmitting virus diseases rather than direct feeding. Therefore, the sucking pests should be considered as economically important.
Patterns and severity of vincristine‐induced peripheral neuropathy in children with acute lymphoblastic leukemia

Vincristine, a critical component of combination chemotherapy treatment for pediatric acute lymphoblastic leukemia (ALL), can lead to vincristine‐induced peripheral neuropathy (VIPN). Longitudinal VIPN assessments were obtained over 12 months from newly diagnosed children with ALL (N = 128) aged 1–18 years who received vincristine at one of four academic children's hospitals. VIPN assessments were obtained using the Total Neuropathy Score‐Pediatric Vincristine (TNS©‐PV), National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE©), Balis© grading scale, and Pediatric Neuropathic Pain Scale©–Five (PNPS©‐5). Of children who provided a full TNS©‐PV score, 85/109 (78%) developed VIPN (TNS©‐PV ≥4). Mean TNS©‐PV, grading scale, and pain scores were low. CTCAE©‐derived grades 3 and 4 sensory and motor VIPN occurred in 1.6%/0%, and 1.9%/0% of subjects, respectively. VIPN did not resolve in months 8–12 despite decreasing dose density. VIPN was worse in older children. Partition cluster analysis revealed 2–3 patient clusters; one cluster (n = 14) experienced severe VIPN. In this population, VIPN occurs more commonly than previous research suggests, persists throughout the first year of treatment, and can be severe.
Geology of the San Colombano hill, a Quaternary isolated tectonic relief in the Po Plain of Lombardy (Northern Italy)

ABSTRACT The 1:10,000 geological map of the San Colombano hill covers 60 km2 in the Po Plain, south of Milan. The new and the historical surface geological data-sets are managed by a GeoDB aiming to contribute to re-interpret the Quaternary evolution at the Po Plain-Northern Apennine border. On the hill, the Calabrian shallow marine San Colombano Fm. unconformably overlies the truncated deeper-marine Miocene formations, up-thrusted by the external fronts of the Apennine Emilian Arc during Mio-Pliocene. Late Pleistocene alluvial units rest in unconformity above the marine succession both on the uplifted hilltop and on the surrounding plain. Fault-related offset of Late Pleistocene units, stratigraphic and morpho-structural evidences (facets, relic surfaces and drainage patterns), document the Quaternary tectonic history. Early to Middle Pleistocene ongoing thrust-folding at the northernmost buried reaches of the Emilian Arc was followed by Latest Pleistocene-Holocene transtension, possibly relating to the NNE striking Pavia-Casteggio lateral ramp.
An Articulatory and Acoustic Study of the Fricative Clusters /sʃ/ and /ʃs/ in Catalan

Abstract Elect ropalatographic and acoustic data for the fricative clusters /sʃ/ and /ʃs/ and the single fricatives /s/ and /ʃ/ in Eastern Catalan reveal that, while /sʃ/ undergoes regressive assimilation, /ʃs/ blends into an intermediate fricative or exhibits a twotarget realization. On the other hand, acoustic data for /ʃs/ in Western Catalan show that /s/ may assimilate to preceding /ʃ/ or undergo blending or a two-target realization depending on speaker and prosodic condition (no data are available for /sʃ/ in this dialect). Duration values for the two fricative clusters suggest that the assimilated outcome of /sʃ/ shortens down to the length of /ʃ/. A production-based account of the two sequences /sʃ/ and /ʃs/ in Catalan and other languages is proposed.
Two distinct sources for a population of maturing axial progenitors

In mammals, the primitive streak region and its descendant, the tail bud, are the source of nascent mesoderm and spinal cord throughout axial elongation. A localised population of long-term axial progenitors has been identified in a region of the tail bud, the chordoneural hinge, but the localisation of such progenitors at earlier stages is so far untested. By studying gene expression, we have shown that a specific topological arrangement of domains persists from the streak to the tail bud, and includes an area (the node-streak border) in which ectoderm that expresses primitive streak markers overlies the prospective notochord. This arrangement persists in the chordoneural hinge. Homotopic grafts show that, as in other vertebrates, cells in the streak and node predominantly produce mesoderm, whereas those in the node-streak border and lateral to the streak additionally produce neurectoderm. Node-streak border descendants populate not only neurectoderm, somites and notochord throughout the axis, but also the chordoneural hinge. Ectoderm lateral to the embryonic day (E)8.5 streak is later recruited to the midline, where it produces somites and chordoneural hinge cells, the position of which overlaps that of border-derived cells. Therefore, the E8.5 axial progenitors that will make the tail comprise cells from two distinct sources: the border and lateral ectoderm. Furthermore, heterotopic grafts of cells from outside the border to this region also populate the chordoneural hinge. Expression of several streak- and tail bud-specific genes declines well before elongation ends, even though this late population can be successfully transplanted into earlier embryos. Therefore, at least some aspects of progenitor status are conferred by the environment and are not an intrinsic property of the cells.
Relationships between phyllosphere bacterial communities and plant functional traits in a neotropical forest

Significance In this study we sequenced bacterial communities present on tree leaves in a neotropical forest in Panama, to quantify the poorly understood relationships between bacterial biodiversity on leaves (the phyllosphere) vs. host tree attributes. Bacterial community structure on leaves was highly correlated with host evolutionary relatedness and suites of plant functional traits related to host ecological strategies for resource uptake and growth/mortality tradeoffs. The abundance of several bacterial taxa was correlated with host growth, mortality, and function. Our study quantifies the drivers of variation in plant-associated microbial biodiversity; our results suggest that incorporating information on plant-associated microbes will improve our understanding of the functional biogeography of plants and plant–microbe interactions. The phyllosphere—the aerial surfaces of plants, including leaves—is a ubiquitous global habitat that harbors diverse bacterial communities. Phyllosphere bacterial communities have the potential to influence plant biogeography and ecosystem function through their influence on the fitness and function of their hosts, but the host attributes that drive community assembly in the phyllosphere are poorly understood. In this study we used high-throughput sequencing to quantify bacterial community structure on the leaves of 57 tree species in a neotropical forest in Panama. We tested for relationships between bacterial communities on tree leaves and the functional traits, taxonomy, and phylogeny of their plant hosts. Bacterial communities on tropical tree leaves were diverse; leaves from individual trees were host to more than 400 bacterial taxa. Bacterial communities in the phyllosphere were dominated by a core microbiome of taxa including Actinobacteria, Alpha-, Beta-, and Gammaproteobacteria, and Sphingobacteria. Host attributes including plant taxonomic identity, phylogeny, growth and mortality rates, wood density, leaf mass per area, and leaf nitrogen and phosphorous concentrations were correlated with bacterial community structure on leaves. The relative abundances of several bacterial taxa were correlated with suites of host plant traits related to major axes of plant trait variation, including the leaf economics spectrum and the wood density–growth/mortality tradeoff. These correlations between phyllosphere bacterial diversity and host growth, mortality, and function suggest that incorporating information on plant–microbe associations will improve our ability to understand plant functional biogeography and the drivers of variation in plant and ecosystem function.
The mRNA Stability Factor HuR Inhibits MicroRNA-16 Targeting of COX-2

Commonly observed in colorectal cancer is the elevated expression of the prostaglandin (PG) synthase COX-2. In normal intestinal epithelium, the COX-2 mRNA is targeted for rapid decay through the 3′-untranslated region (3′-UTR) adenylate- and uridylate (AU)-rich element (ARE), whereas in tumors ARE-mediated decay is compromised. Here we show that the COX-2 ARE can mediate degradation through microRNA (miRNA)-mediated regulation. We identified miR-16 to bind the COX-2 3′-UTR and inhibit COX-2 expression by promoting rapid mRNA decay. In colorectal cancer cells and tumors, miR-16 levels were decreased approximately twofold and miR-16 expression in cancer cells attenuated COX-2 expression and PG synthesis. The COX-2 ARE is also bound by the RNA-binding protein HuR. In colorectal cancer tumors, HuR is overexpressed and localized within the cytoplasm, where it promotes ARE-mRNA stabilization. Under conditions of HuR overexpression, miR-16 was unable to promote rapid mRNA decay through the COX-2 ARE. Ribonucleoprotein immunoprecipitation of HuR showed direct association with miR-16 that was reversed when cytoplasmic trafficking of HuR was inhibited. Furthermore, this interaction between HuR and miR-16 promoted the downregulation of miR-16. These new results identify miR-16 as a central posttranscriptional regulator of COX-2 and show the ability of elevated levels of HuR to antagonize miR-16 function. Along with insight into altered ARE-mediated mRNA decay observed in colorectal cancer, these findings provide a new explanation for tumor-derived loss of miR-16. Mol Cancer Res; 10(1); 167–80. ©2011 AACR.
Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes

Objectives To evaluate fasting serum insulin levels and insulin resistance, and their association with blood rheology, in Japanese young adults without diabetes. Methods Blood samples were analysed and blood rheology was estimated using haematological parameters. Whole blood passage time was measured using a Hitachi MC-FAN© microchannel array flow analyser. Results Out of 151 subjects (mean age, 24.1 ± 1.5 years), fasting serum insulin levels and insulin resistance (using homeostasis model assessment-estimated insulin resistance [HOMA-IR]), were positively correlated with longer whole blood passage times and higher values for haematocrit (Hct), haemoglobin (Hb), fibrinogen, body weight, body mass index (BMI), triglycerides, and low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio, and were negatively correlated with HDL-C. Whole blood passage time correlated with body weight, BMI, LDL-C/HDL-C ratio, Hct, Hb, white blood cell (WBC) count, platelet count, fibrinogen, fasting serum insulin levels, and HOMA-IR. Multiple regression analysis revealed that whole blood passage time was independently associated with Hct, fibrinogen levels, and WBC count. Conclusions Fasting serum insulin levels and insulin resistance were associated with blood rheology, and may influence blood rheology by modulating haematological parameters and lipid parameters in young adults without diabetes.
Do Impressions of Health, Dominance, and Warmth Explain Why Masculine Faces are Preferred More in a Short-Term Mate?

Men high in facial masculinity are preferred more as a short-term partner (STP) than a long-term partner (LTP). We used a representative sample of natural faces to examine whether the greater preference for masculine-looking men as a STP could be explained by the fact that they look healthier, more dominant, or lower in warmth. None of these attributes explained the greater preference for facial masculinity in a STP. Rather, masculinity mediated the greater preference for healthy and dominant looking men as a STP. Women also preferred men who appeared high in warmth more as a LTP than a STP, an effect independent of facial masculinity, but mediated by facial expression. Our results suggest that women do not prefer masculine-looking men more as a STP than a LTP simply because they look healthier, more dominant, or less warm.
Achieving Multiprogramming Scalability on Intel SMP Platforms: Nanothreading in the Linux Kernel

This paper presents the architecture and implementation of a anothreadinginterface in the kernel of the Linux operating system for Intel Pentium-base d ymmetric multiprocessors. The nanothreading interface aims at achieving scalability of p arallel programs in multiprogrammed shared memory multiprocessors, where multiple parallel an d sequential programs with diverge characteristics and resource requirements execute simult aneously. The main idea of the nanothreading interface is to let parallel programs and the kernel exchange critical scheduling information through shared memory with minimal overhead, in orde r to let parallel programs adapt to dynamically changing resources and ensure that all progr ams running in the system will minimize their idle time and make always progress along thei r critical path. We evaluate both the overhead of the low-level nanothreading mechanisms and the efficiency of the nanothreading interface in terms of system throughput, using multipro grammed workloads with parallel benchmarks. Our results substantiate the efficiency of our i mplementation and demonstrate that the nanothreading kernel provides solid improvements over the native Linux SMP kernel.
Harnessing Soft Computations for Low-Budget Fault Tolerance

A growing number of applications from various domains such as multimedia, machine learning and computer vision are inherently fault tolerant. However, for these soft workloads, not all computations are fault tolerant (e.g., A loop trip count). In this paper, we propose a compiler-based approach that takes advantage of soft computations inherent in the aforementioned class of workloads to bring down the cost of software-only transient fault detection. The technique works by identifying a small subset of critical variables that are necessary for correct macro-operation of the program. Traditional duplication and comparison are used to protect these variables. For the remaining variables and temporaries that only affect the micro-operation of the program, strategic expected value checks are inserted into the code. Intuitively, a computation-chain result near the expected value is either correct or close enough to the correct result so that it does not matter for non-critical variables. Overall, the proposed solution has, on average, only 19.5% performance overhead and reduces the number of silent data corruptions from 15% down to 7.3% and user-visible silent data corruptions from 3.4% down to 1.2% in comparison to an unmodified application. This unacceptable silent data corruption rate is even lower than a traditional full duplication scheme that has, on average, 57% overhead.
Effect of anaerobic dairy manure co-digestion and effluent solid separation on volatile fatty acids during manure storage

This is to certify that the thesis/dissertation prepared By Entitled For the degree of Is approved by the final examining committee: Chair To the best of my knowledge and as understood by the student in the Research Integrity and Copyright Disclaimer (Graduate School Form 20), this thesis/dissertation adheres to the provisions of Purdue University's " Policy on Integrity in Research " and the use of copyrighted material. ii For my family and Jim and Deloris Holiman. iii ACKNOWLEDGEMENTS
Scanning Electron Microscopy and Histological Morphology of Cysticercus fasciolaris , which induced Fibrosarcomas in Laboratory Rats

Cysticercus fasciolaris is the larval stage of Taenia taeniaeformis and it is a feline tapeworm. The objectives of this study were to determine the C. fasciolaris morphology using scanning electron microscopy (SEM) and light microscopy (LM) and its effects on the laboratory rats’ liver. Methods: A total of 21 liver specimens of male Sprague-Dawley laboratory rats were collected and tissue specimen form infected liver that involved C. fasciolaris cysts was obtained for LM and SEM studies. Results: Gross pathology of the infected livers showed the harboured hepatic cysts as single or multicystic structures. Histopathological examination revealed the presence of multiple hepatic cysts, and the C. fasciolaris larva was surrounded by granulation tissue. Large and separated fi broblasts in different orientations with some neoplastic changes that suggest fi brosarcomas were seen in advanced hepatic cysticercosis. The SEM of mature C. fasciolaris bladder appeared contains small chamber that involved the larva and large chamber containing the small chamber and opalescent fl uid. The scolex of the mature larva is distinctly large, bearing four lateral distinct suckers, a rostellum armed with double, and alternating rings of double circlet of hooks. In conclusion, the C. Fasciolaris might induce hepatofi brosarcomas in the rats liver in advance cases.
On pointwise estimates involving sparse operators

We obtain an alternative approach to recent results by M. Lacey \cite{La} and T. Hyt\"onen {\it et al.} \cite{HRT} about a pointwise domination of $\omega$-Calder\'on-Zygmund operators by sparse operators. This approach is rather elementary and it also works for a class of non-integral singular operators.
Relation between Hypoxic Markers P65, P50, CAIX, and Tumor Stages in Invasive Ductal Carcinoma Subtypes

Background: Nuclear factor-kappa B (NF-B) family comprises 5 members (p50, p52, relA/p65, c-rel and relB) which are induced in response to a wide variety of stimuli including hypoxia. Continuous activation of NF-B is an important factor in the onset and progression of breast carcinoma. Hypoxia also induces carbonic anhydrase 9 (CAIX) that regulates pH and is linked to poor prognosis in breast cancer. Research motivation: The current study aims to investigate the relation between hypoxic markers, p65, p50, CAIX and tumor stage in IDC (invasive ductal carcinoma) subtypes. Research design/methodology: The study included 31 IDC patients. Breast tissues collected during surgery and classified according to estrogen receptor alpha (ER, progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) status. Normal breast tissues were also collected to serve as self controls. Nuclear protein extracted and both RelA/p65 and p50 protein assessed by ready to use enzyme-linked immunosorbent assay (ELISA) and a transcription factor assay kits; respectively. CAIX protein expression was detected by blotting techniques. Main findings: RelA/p65 concentration significantly increased in breast carcinoma (p = 0.028) irrelevant to tumor stage, size, grade, nodal status, p50, CAIX or IDC subtypes. P50 binding activity significantly increased with higher tumor grade (P = 0.042). A significant inverse correlation was observed between p50 and ER (r = -0.53, p = 0.002) and between CAIX and the number of the involved lymph nodes (r = -0.42, p = 0.020). Implications: Although no relation was observed between p65, p50, and CAIX, binding activity of p50 and CAIX concentration might be used as prognostic markers in IDC.
The TAGteam DNA motif controls the timing of Drosophila pre-blastoderm transcription

The Drosophila sex-determination switch gene Sex-lethal (Sxl) and the X-chromosome signal element genes (XSEs) that induce the female-specific expression of Sxl are transcribed extremely early in development when most of the genome of this organism is still silent. The DNA sequence CAGGTAG had been implicated in this pre-cellular blastoderm activation of sex-determination genes. A genome-wide computational search, reported here, suggested that CAGGTAG is not specific to early sex-determination genes, since it is over-represented upstream of most genes that are transcribed pre-cellular blastoderm, not just those involved in sex determination. The same search identified similarly over-represented, one-base-pair degenerate sequences as possible functional synonyms of CAGGTAG. We call these heptamers collectively, the TAGteam. Relevance of the TAGteam sequences to pre-cellular blastoderm transcription was established through analysis of TAGteam changes in Sxl, scute (an XSE), and the `ventral repression element' of the pattern-formation gene zerknüllt. Decreasing the number of TAGteam sites retarded the onset of pre-blastoderm transcription, whereas increasing their number correlated with an advanced onset. Titration of repressors was thought to be the rate-limiting step determining the onset of such early transcription, but this TAGteam dose effect shows that activators must also play an important role in the timing of pre-blastoderm gene expression.