Miracle-dz/UniFAR-FTUs huggingface dataset:
Hollow silica, metal, and plastic waveguides for hard-tissue medical applications

A new type of flexible hollow waveguide made of polyimide was developed. Mechanical bending and flexibility of the polyimide was changed and brought to be similar to that of Teflon hollow waveguide using a plastic sleeve. The optical characteristics of this new waveguide were studied and it was shown that high power (up to 25) Watts of carbon-dioxide laser radiation can be delivered. The delivered power remained constant for more than 150 seconds, which shows that the polyimide waveguides may be suitable for applications in medicine, where the requested maximum delivered power is about 20 Watts. Transmission (T) as a function of bending (1/R), where R is the radius of curvature, has shown that very strong bending may be obtained (R greater than or equal to 4 mm) without damage to the waveguide. Also demonstrated was the importance of angle, in addition to the radius of bending. The measurements of divergence of delivered beam was small (approximately 10-3), which is comparable with those obtained for core fibers. Beam profile measurements have shown that the shape and mode distribution of the delivered radiation from waveguide are similar to that delivered by the coupled carbon-dioxide radiation. The measured value of maximum accepted incident angle of the beam on the internal wall of the waveguide was about 12 degrees which is larger than of silica and Teflon waveguides.
Temporal Coding of Visual Information in the Thalamus

The amount of information a sensory neuron carries about a stimulus is directly related to response reliability. We recorded from individual neurons in the cat lateral geniculate nucleus (LGN) while presenting randomly modulated visual stimuli. The responses to repeated stimuli were reproducible, whereas the responses evoked by nonrepeated stimuli drawn from the same ensemble were variable. Stimulus-dependent information was quantified directly from the difference in entropy of these neural responses. We show that a single LGN cell can encode much more visual information than had been demonstrated previously, ranging from 15 to 102 bits/sec across our sample of cells. Information rate was correlated with the firing rate of the cell, for a consistent rate of 3.6 ± 0.6 bits/spike (mean ± SD). This information can primarily be attributed to the high temporal precision with which firing probability is modulated; many individual spikes were timed with better than 1 msec precision. We introduce a way to estimate the amount of information encoded in temporal patterns of firing, as distinct from the information in the time varying firing rate at any temporal resolution. Using this method, we find that temporal patterns sometimes introduce redundancy but often encode visual information. The contribution of temporal patterns ranged from −3.4 to +25.5 bits/sec or from −9.4 to +24.9% of the total information content of the responses.
Determination of the elastic properties of short ssDNA molecules by mechanically folding and unfolding DNA hairpins

The characterization of elastic properties of biopolymers is crucial to understand many molecular reactions determined by conformational bending fluctuations of the polymer. Direct measurement of such elastic properties using single‐molecule methods is usually hindered by the intrinsic tendency of such biopolymers to form high‐order molecular structures. For example, single‐stranded deoxyribonucleic acids (ssDNA) tend to form secondary structures such as local double helices that prevent the direct measurement of the ideal elastic response of the ssDNA. In this work, we show how to extract the ideal elastic response in the entropic regime of short ssDNA molecules by mechanically pulling two‐state DNA hairpins of different contour lengths. This is achieved by measuring the force dependence of the molecular extension and stiffness on mechanically folding and unfolding the DNA hairpin. Both quantities are fit to the worm‐like chain elastic model giving values for the persistence length and the interphosphate distance. This method can be used to unravel the elastic properties of short ssDNA and RNA sequences and, more generally, any biopolymer that can exhibit a cooperative two‐state transition between mechanically folded and unfolded states (such as proteins). © 2014 Wiley Periodicals, Inc. Biopolymers 101: 1193–1199, 2014.
Aqueous Two-Phase Systems Applied to Partition Proteins from Goat Milk Whey In-Nature

The proteins coming from the milk whey have numerous functional properties. Among the proteins with high bioactivity, α-lactoalbumin (α-La) and β-lactoglobulin (β-Lg) are present in large quantities in the milk whey. In the separation process of proteins, it is important to choose techniques which besides ensuring purity and high yield will not affect the molecule biological activity. The aqueous two-phase systems (ATS) have been utilized with success in the partition of these proteins, however, the studies were performed using protein in its pure form. Studies using milk whey in-nature and goat milk whey have not been found yet. In this context, the objective of this study was to evaluate the liquid liquid equilibrium of aqueous two-phase systems (ATS) in the partition of α-La and β-Lg from goat milk whey in-nature. Equilibrium data were performed considering ATS comprised of polyethylene glycol, potassium phosphate and water at 25°C and pH 7.0. The influence of the polymer molecular weight and amount of goat milk whey in-nature on the partition coefficient of these proteins were assessed. The partition coefficient, selectivity, process yield and purity of α-lactoalbumin and β-lactoglobulin proteins were determined. The results showed that the separation technique by aqueous biphasic systems is applicable indicating high efficiency in the whey proteins separation process.
Analysis of FLT 3 length mutations in 1003 patients with acute myeloid leukemia : correlation to cytogenetics , FAB subtype , and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

FLT3 length mutation (FLT3-LM) is a molecular marker potentially useful for the characterization of acute myeloid leukemia (AML). To evaluate the distribution of FLT3-LM within biologic subgroups, we screened 1003 patients with AML at diagnosis for this mutation. FLT3-LM was found in 234 (23.5%) of all patients and thus is the most frequent mutation in AML described so far. Of all positive patients, 165 (70.5%) revealed a normal karyotype. Of the 69 patients with chromosome aberrations, 24 (34.8%) had a t(15;17). The mutation was rare in AML with t(8;21), inv(16) 11q23 rearrangements, and complex karyotypes. FLT3-LM was not distributed equally within different FrenchAmerican-British (FAB) subtypes and was correlated with a high peripheral blood count in FAB M1, M2, and M4 (P < .0001). In addition, the median age of patients with the mutation was lower (54.9 vs 57.6 years; P .043), and, at a ratio of 1.36:1 (P .023), the mutation was more frequent in females than in males. Within the AMLCG study, FLT3-LM was of intermediate prognostic significance. The complete remission rate of 70.3% in patients with FLT3-LM was similar to that (70.4%) in patients without FLT3-LM. Overall survival was not different between patients with or without FLT3-LM. In contrast, patients with FLT3-LM had a significantly shorter event-free survival (7.4 vs 12.6 months; P .0072) because of a higher relapse rate. Besides the importance of FLT3-LM for biologic and clinical characterization of AML, we show its value as a marker for disease monitoring based on 120 follow-up samples of 34 patients. (Blood. 2002;100:59-66)
Changes in Body Mass Index Associated With Head Start Participation

OBJECTIVES: The goal of this study was to determine if Head Start participation is associated with healthy changes in BMI. METHODS: The sample included children participating in Head Start between 2005 and 2013 and children from 2 comparison groups drawn from a Michigan primary care health system: 5405 receiving Medicaid and 19 320 not receiving Medicaid. Change in BMI z score from the beginning to the end of each of 2 academic years and the intervening summer was compared between groups by using piecewise linear mixed models adjusted for age, gender, and race/ethnicity. RESULTS: The total sample included 43 748 children providing 83 239 anthropometric measures. The Head Start sample was 64.9% white, 10.8% black, and 14.4% Hispanic; 16.8% of the children were obese and 16.6% were overweight at the initial observation. Children who entered Head Start as obese exhibited a greater decline in the BMI z score during the first academic year versus the comparison groups (β = –0.70 [SE: 0.05] vs –0.07 [0.08] in the Medicaid group [P < .001] and –0.15 [SE: 0.05] in the Not Medicaid group [P < .001]); patterns were similar for overweight children. Head Start participants were less obese, less overweight, and less underweight at follow-up than children in the comparison groups. CONCLUSIONS: Preschool-aged children with an unhealthy weight status who participated in Head Start had a significantly healthier BMI by kindergarten entry age than comparison children in a primary care health system (both those receiving and those not receiving Medicaid).
Web 2.0 and competence-oriented design of learning - Potentials and implications for higher education

This paper discusses the potential of learning technologies to foster competence development of students. It aims to improve understanding of pedagogical conditions that have to be met to establish a competence orientation in e-learning. We review the literature to summarise recent changes in e-learning, identify attributes of web 2.0 technologies, revisit the concept of competence and specify implications for the competence-oriented design of learning environments. By referring to Kolb's learning cycle, we illustrate this view with a case study on the use of Google Apps as collaborative learning environment and recommend how competence-oriented e-learning activities can be created. Our findings reinforce the position that web 2.0 tools enable a shift from a distributive to a more collaborative mode in e-learning. In particular, the ease of use and intuition of web 2.0 technologies allow creating learning environments, which realise activity-rich pedagogical models and facilitate competence development of students. The paper concludes that, despite the demand of firms for versatile graduates and the obvious potential of learning technologies to foster competence development of students, universities need to establish institutional strategies to make this pedagogical change happen. [ABSTRACT FROM AUTHOR]
Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors.

BACKGROUND Increased awareness of the importance of vitamin D to health has led to concerns about the prevalence of hypovitaminosis D in many parts of the world. OBJECTIVES We aimed to determine the prevalence of hypovitaminosis D in the white British population and to evaluate the influence of key dietary and lifestyle risk factors. DESIGN We measured 25-hydroxyvitamin D [25(OH)D] in 7437 whites from the 1958 British birth cohort when they were 45 y old. RESULTS The prevalence of hypovitaminosis D was highest during the winter and spring, when 25(OH)D concentrations <25, <40, and <75 nmol/L were found in 15.5%, 46.6%, and 87.1% of participants, respectively; the proportions were 3.2%, 15.4%, and 60.9%, respectively, during the summer and fall. Men had higher 25(OH)D concentrations, on average, than did women during the summer and fall but not during the winter and spring (P = 0.006, likelihood ratio test for interaction). 25(OH)D concentrations were significantly higher in participants who used vitamin D supplements or oily fish than in those who did not (P < 0.0001 for both) but were not significantly higher in participants who consumed vitamin D-fortified margarine than in those who did not (P = 0.10). 25(OH)D concentrations <40 nmol/L were twice as likely in the obese as in the nonobese and in Scottish participants as in those from other parts of Great Britain (ie, England and Wales) (P < 0.0001 for both). CONCLUSION Prevalence of hypovitaminosis D in the general population was alarmingly high during the winter and spring, which warrants action at a population level rather than at a risk group level.
The transport of vitamin C and effects of disease

It has been known for a number of years that high concentrations of vitamin C (ascorbic acid + dehydroascorbic acid) occur in some cells, but it is only recently that we have begun to discover how high the levels are and also that the vitamin seems to be secreted onto epithelial surfaces (Table 1). If we assume that such concentrations and secretions are needed for the appropriate biological activity of the vitamin, it follows that transport of vitamin C will be required in order to sustain normal metabolic functions. Further, if transport is central to the metabolism of vitamin C, any defect in the process could lead to the development of disease. The study of transport mechanisms is, therefore, important in our understanding of vitamin C metabolism and this review will examine our present knowledge in this area and speculate on diseases that may impair these processes.
An experimental test of Rubinstein's bargaining model

This paper offers an experimental test of a version of Rubinstein’s bargaining model in which the players’ discount factors are unequal. We find that learning, rationality, and fairness are all significant in determining the outcome. In particular, we find that a model of myopic optimization over time predicts the sign of deviations in the opening proposal from the final undiscounted agreement in the previous period rather well. To explain the amplitude of the deviations, we then successfully fit a perturbed version of the model of myopic adjustment to the data that allows for a bias toward refusing inequitable offers.
Joining Extractions of Regular Expressions

Regular expressions with capture variables, also known as "regex formulas,'' extract relations of spans (interval positions) from text. These relations can be further manipulated via the relational Algebra as studied in the context of "document spanners," Fagin et al.'s formal framework for information extraction. We investigate the complexity of querying text by Conjunctive Queries (CQs) and Unions of CQs (UCQs) on top of regex formulas. Such queries have been investigated in prior work on document spanners, but little is known about the (combined) complexity of their evaluation. We show that the lower bounds (NP-completeness and W[1]-hardness) from the relational world also hold in our setting; in particular, hardness hits already single-character text. Yet, the upper bounds from the relational world do not carry over. Unlike the relational world, acyclic CQs, and even gamma-acyclic CQs, are hard to compute. The source of hardness is that it may be intractable to instantiate the relation defined by a regex formula, simply because it has an exponential number of tuples. Yet, we are able to establish general upper bounds. In particular, UCQs can be evaluated with polynomial delay, provided that every CQ has a bounded number of atoms (while unions and projection can be arbitrary). Furthermore, UCQ evaluation is solvable with FPT (Fixed-Parameter Tractable) delay when the parameter is the size of the UCQ.
Managing Peer-to-Peer Conflicts in Disruptive Information Technology Innovations: The Case of Software Reuse

We examine the case of software reuse as a disruptive information technology innovation (i.e., one that requires changes in the architecture of work processes) in software development organizations. Using theories of conflict, coordination, and learning, we develop a model to explain peer-to-peer conflicts that are likely to accompany the introduction of disruptive technologies and how appropriately devised managerial interventions (e.g., coordination mechanisms and organizational learning practices) can lessen these conflicts. A study of software reuse programs in four organizations was conducted to assess the validity of the model. Qualitative and quantitative analyses of the data obtained showed that companies that had implemented such managerial interventions experienced greater success with their software reuse programs. Implications for theory and practice are discussed.
r-Process Abundance Signatures in Metal-Poor Halo Stars

Abundance observations indicate the presence of rapid-neutron capture (i.e., r-process) elements in old Galactic halo and globular cluster stars. Recent observations of the r-process-enriched star BD +17 3248 include new abundance determinations for the neutron-capture elements Cd I (Z=48), Lu II (Z = 71) and Os II (Z = 76), the first detections of these elements in metal-poor r-process-enriched halo stars. Combining these and previous observations, we have now detected 32 n-capture elements in BD +17 3248. This is the most of any metal-poor halo star to date. For the most r-process-rich (i.e. [Eu/Fe] ~= 1) halo stars, such as CS 22892-052 and BD +17 3248, abundance comparisons show that the heaviest stable n-capture elements (i.e., Ba and above, Z >= 56) are consistent with a scaled solar system r-process abundance distribution. The lighter n-capture element abundances in these stars, however, do not conform to the solar pattern. These comparisons, as well as recent observations of heavy elements in metal-poor globular clusters, suggest the possibility of multiple synthesis mechanisms for the n-capture elements. The heavy element abundance patterns in most metal-poor halo stars do not resemble that of CS 22892-052, but the presence of heavy elements such as Ba in nearly all metal-poor stars without s-process enrichment indicates that r-process enrichment in the early Galaxy is common.
Experimental and Numerical Study on Tensile Strength of Concrete under Different Strain Rates

The dynamic characterization of concrete is fundamental to understand the material behavior in case of heavy earthquakes and dynamic events. The implementation of material constitutive law is of capital importance for the numerical simulation of the dynamic processes as those caused by earthquakes. Splitting tensile concrete specimens were tested at strain rates of 10−7 s−1 to 10−4 s−1 in an MTS material test machine. Results of tensile strength versus strain rate are presented and compared with compressive strength and existing models at similar strain rates. Dynamic increase factor versus strain rate curves for tensile strength were also evaluated and discussed. The same tensile data are compared with strength data using a thermodynamic model. Results of the tests show a significant strain rate sensitive behavior, exhibiting dynamic tensile strength increasing with strain rate. In the quasistatic strain rate regime, the existing models often underestimate the experimental results. The thermodynamic theory for the splitting tensile strength of concrete satisfactorily describes the experimental findings of strength as effect of strain rates.
The total cavopulmonary connection resistance: a significant impact on single ventricle hemodynamics at rest and exercise.

Little is known about the impact of the total cavopulmonary connection (TCPC) on resting and exercise hemodynamics in a single ventricle (SV) circulation. The aim of this study was to elucidate this mechanism using a lumped parameter model of the SV circulation. Pulmonary vascular resistance (1.96+/-0.80 WU) and systemic vascular resistances (18.4+/-7.2 WU) were obtained from catheterization data on 40 patients with a TCPC. TCPC resistances (0.39+/-0.26 WU) were established using computational fluid dynamic simulations conducted on anatomically accurate three-dimensional models reconstructed from MRI (n=16). These parameters were used in a lumped parameter model of the SV circulation to investigate the impact of TCPC resistance on SV hemodynamics under resting and exercise conditions. A biventricular model was used for comparison. For a biventricular circulation, the cardiac output (CO) dependence on TCPC resistance was negligible (sensitivity=-0.064 l.min(-1). WU(-1)) but not for the SV circulation (sensitivity=-0.88 l.min(-1). WU(-1)). The capacity to increase CO with heart rate was also severely reduced for the SV. At a simulated heart rate of 150 beats/min, the SV patient with the highest resistance (1.08 WU) had a significantly lower increase in CO (20.5%) compared with the SV patient with the lowest resistance (50%) and normal circulation (119%). This was due to the increased afterload (+35%) and decreased preload (-12%) associated with the SV circulation. In conclusion, TCPC resistance has a significant impact on resting hemodynamics and the exercise capacity of patients with a SV physiology.
Morton Neuroma: Evaluated with Ultrasonography and MR Imaging

Objective The purpose of this study was to compare the diagnostic accuracy of both ultrasonography (US) and magnetic resonance imaging (MRI) for the assessment of Morton neuroma. Materials and Methods Our study group was comprised of 20 neuromas from 17 patients, and the neuromas were confirmed on surgery following evaluation with US, MRI, or both US and MRI. The diagnostic criterion for Morton neuroma, as examined by US, was the presence of a round or ovoid, well-defined, hypoechoic mass. The diagnostic criterion, based on MR imaging, was a well defined mass with intermediate to low signal intensity on both the T1- and T2-weighted images. The retrospective comparison between the sonographic and MR images was done by two experienced radiologists working in consensus with the surgical and pathologic correlations. Results The detection rate of Morton neuroma was 79% for 14 neuromas from 11 patients who had undergone US followed by an operation. The detection rate was 76% for 17 neuromas from 15 patients who had undergone MRI and a subsequent operation. The mean size of the examined neuromas was 4.9 mm on the US images and it was 5.1 mm on the MRI studies. Ten neuromas (71%) were 5 mm or less as measured by US, and three neuromas were not detected, whereas on the MRI analysis, 10 neuromas (59%) were 5 mm or less and four neuromas were not visualized. Among the patients examined during postoperative follow-up, symptoms were completely relieved in 85% and the symptoms were partially relieved in 15%. Conclusion US and MR imaging are comparable modalities with high detection rate for the evaluation of Morton neuroma.