Miracle-dz/UniFAR-FTUs huggingface dataset:
America’s Cup Sailing: Effect of Standing Arm-Cranking (“Grinding”) Direction on Muscle Activity, Kinematics, and Torque Application

Grinding is a key physical element in America’s Cup sailing. This study aimed to describe kinematics and muscle activation patterns in relation to torque applied in forward and backward grinding. Ten male America’s Cup sailors (33.6 ± 5.7 years, 97.9 ± 13.4 kg, 186.6 ± 7.4 cm) completed forward and backward grinding on a customised grinding ergometer. In forward grinding peak torque (77 Nm) occurred at 95° (0° = crank vertically up) on the downward section of the rotation at the end of shoulder flexion and elbow extension. Backward grinding torque peaked at 35° (69 Nm) following the pull action (shoulder extension, elbow flexion) across the top of the rotation. During forward grinding, relatively high levels of torque (>50 Nm) were maintained through the majority (72%) of the cycle, compared to 47% for backward grinding, with sections of low torque corresponding with low numbers of active muscles. Variation in torque was negatively associated with forward grinding performance (r = −0.60; 90% CI −0.88 to −0.02), but positively associated with backward performance (r = 0.48; CI = −0.15 to 0.83). Magnitude and distribution of torque generation differed according to grinding direction and presents an argument for divergent training methods to improve forward and backward grinding performance.
Comparison of Bayesian and maximum-likelihood inference of population genetic parameters

UNLABELLED Comparison of the performance and accuracy of different inference methods, such as maximum likelihood (ML) and Bayesian inference, is difficult because the inference methods are implemented in different programs, often written by different authors. Both methods were implemented in the program MIGRATE, that estimates population genetic parameters, such as population sizes and migration rates, using coalescence theory. Both inference methods use the same Markov chain Monte Carlo algorithm and differ from each other in only two aspects: parameter proposal distribution and maximization of the likelihood function. Using simulated datasets, the Bayesian method generally fares better than the ML approach in accuracy and coverage, although for some values the two approaches are equal in performance. MOTIVATION The Markov chain Monte Carlo-based ML framework can fail on sparse data and can deliver non-conservative support intervals. A Bayesian framework with appropriate prior distribution is able to remedy some of these problems. RESULTS The program MIGRATE was extended to allow not only for ML(-) maximum likelihood estimation of population genetics parameters but also for using a Bayesian framework. Comparisons between the Bayesian approach and the ML approach are facilitated because both modes estimate the same parameters under the same population model and assumptions.
Managerial support for learning at work: a qualitative study of first‐line managers in elder care

Purpose – The aim of the present study is to explore the meaning of managerial support for learning and development in the workplace. The overall research question concerns how first‐line managers in elder care perceive and understand their mission and tasks and how they in practice handle issues of co‐workers' learning and development.Design/methodology/approach – The study was designed as a multiple‐case study including eight first‐line mangers in eight care units. Data were collected through interviews and observations.Findings – The study demonstrates the variation that exists concerning how first‐line managers understand and enact their tasks. Specifically, it is possible to distinguish four qualitatively different patterns concerning how the managers acted and interacted with their co‐workers.Research limitations/implications – The empirical generalisability of the results is limited by its character as a multiple‐case study of eight managers in eight different work units. At the same time, the stre.
On-the-fly lattice rescoring for real-time automatic speech recognition

This paper presents a method for rescoring the speech recognition lattices on-the-ﬂy to increase the word accuracy while preserving low latency of a real-time speech recognition sys-tem. In large vocabulary speech recognition systems, pruned and/or lower order n -gram language models are often used in the ﬁrst-pass of the speech decoder due to the computational complexity. The output word lattices are rescored ofﬂine with a better language model to improve the accuracy. For real-time speech recognition systems, ofﬂine lattice rescoring increases the latency of the system and may not be appropriate. We pro-pose a method for on-the-ﬂy lattice rescoring and generation, and evaluate it on a broadcast speech recognition task. This ﬁrst-pass lattice rescoring method can generate rescored lattices with less than 20% increased computation over standard lattice generation without increasing the latency of the system.
Globalisation of Indian Diets and the Transformation of Food Supply Systems Inaugural

This paper examines the change in the nature of food demand in India in the last twenty years. It identifies two distinct stages of diet transition associated with the period of economic growth. During the first stage, income-induced diet diversification, consumers move away from inferior goods to superior foods and substitute some traditional staples, especially rice. In the second stage, diet globalisation, the influences of globalisation are much more marked with increased consumption of proteins, sugars and fats. Diet diversification has marked the process of transformation in food production systems. The implications for small and marginal farmers could be serious, unless there are incentives and policies that allow them to move away from subsistence agriculture and become more integrated in the global food market.
Deliver us from evil: religion as insurance

This paper focusses on the insurance role of religion in buffering the well-being impact of stressful life events, and the ensuing economic and social implications. Using two large-scale European data sets, we show that the religious enjoy higher levels of life satisfaction, and that religion does insure against some adverse life events. All denominations suffer less psychological harm from unemployment than do the non-religious; equally both Catholics and Protestants are less hurt by marital separation. However, while Protestants are protected against divorce, Catholics are punished for it. These results do not seem to come about from the endogeneity of religion. These patterns in subjective well-being correspond to data on both attitudes (the religious are both anti-divorce and anti-job creation for the unemployed) and behaviour (the religious unemployed are less likely to be actively looking for work). In panel data, as implied by insurance, the religious have less variation in life satisfaction. Last, we suggest that religion's insurance role might be reflected in support for different economic and social systems: consistent with this, unemployment replacement rates across Europe are lower in more religious countries.
Understanding Factors that Affect Level of Oral Communication Apprehension between Accounting and Non Accounting Students: A Literature Review

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Estimation of human upper body orientation for mobile robotics using an SVM decision tree on monocular images

In this paper, we present a monocular, texture-based method for person detection and upper-body orientation classification. We build on a commonly used approach for person recognition that uses a Support Vector Machine (SVM) on Histograms of Oriented Gradients (HOG) [1] but replace the SVM by a decision tree with SVMs as binary decision makers. Thereby, in addition to the pure detection of persons, the distinction of eight upper-body orientation classes is enabled. The detection of humans and the estimation of their upper-body orientation from larger distances is essential for socially acceptable navigation of mobile robots. It permits to estimate the human's notice of the robot or even the human's interest in an interaction. Thus, it is the basis for the decision whether to approach or to avoid a human. By using an SVM decision tree for upper-body orientation estimation in discrete steps of 45°, we were able to classify about 64% of the test samples with an absolute error of less than 22.5°. This performance is much better than the results we obtained with comparable methods. Furthermore, our approach proved to be faster than the other state-of-the-art methods. This is of high relevance for implementation on mobile robots with limited computational resources.
Adaptation in the BHPS

Andrew E. Clark (Paris School of Econom ics, France and IZA, Germ any) Yannis Georgellis (Brunel University, UK) January 2010 Abstract W e look for evidence of adaptation of well-being to m ajor life events in sixteen waves of British panel data. We find that, with the exception of unemployment, adaptation to other life events including marriage, divorce, birth of a child and widowhood is rapid and complete. These findings are rem arkably sim ilar to those found in previous analys is of Germ an panel data. Equally, the tim e profiles of well-being as m easured by life satis faction data are very close to those from the analysis of a twelve-item scale of psychological functioning. As such, th e phenom enon of adaptation m ay be a general one, rather than being only found in Germ an data or using single-item measures. Last, we uncover som e system atic differences in adaptation profiles according to Big Five personality m easures. JEL Codes : I31, J12, J13, J63, J64. Keyw ords: Life Satisfaction; Anticipation; Adaptation; Baseline Satisfaction; Labour Market and Life Events. Address for Correspondence: Andrew Clark, PSE, 48 Boulevard Jourdan, 75014 Paris, France. Tel: +33-1-43-13-63-29. E-m ail: Andrew.Clark@ens.fr.
Longitudinal Student Research Competency: Comparing Online and Traditional Face-to-Face Learning Platforms

This exploratory research compares longitudinal research self-efficacy and retention between a completely asynchronous Master of Social Work (MSW) online cohort and its traditional face-to-face counterpart. This study used a non-equivalent comparison groups design with two groups: online instruction only (n=16) and traditional face-to-face instruction (n=32), with pretest (Time 1), posttest (Time 2) and follow-up (Time 3) standardized measures of practice evaluation knowledge (PEKS) and research self-efficacy (RSES) in a beginning research methods course. Results indicate that students’ knowledge and research self-efficacy improved between pretest and posttest and remained significantly improved at follow-up one year later, with no significant difference between online learners and traditional face-to-face students. Students gain and maintain confidence in research methods and evaluation regardless of the learning platform utilized.
Effects of Financial Autarky and Integration: The Case of the South Africa Embargo

The economic embargo imposed on South Africa between 1985 and 1993 brought the country closer to financial isolation. This paper interprets the imposition and removal of the embargo as financial autarky and financial integration ‘natural experiments’, and studies the effects on the economy. The aggregate data indicate a decrease in the levels and growth rates of investment, capital, and output during the embargo period relative to the pre-embargo and post-embargo periods. To further rationalize the findings in the aggregate data, we calibrate a neoclassical growth model to the South African economy. During the transition to steady-state, we model the embargo by limiting the country’s ability to borrow for a period corresponding to the duration of the embargo. The derived dynamics for investment, capital, and output support the view of a positive (negative) link between financial integration (isolation) and economic growth.
Current Proposed Mechanisms of Action of Intravenous Immunoglobulins in Inflammatory Neuropathies

Intravenous immunoglobulins (IVIg) have been shown in a number of trials, to be an effective treatment for the three main types of inflammatory neuropathies: Guillain-Barré Syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is thought to exert its immunomodulatory effects by affecting several components of the immune system including B-cells, T-cells, macrophages, complement, cytokines and cellular adhesion molecules. This article reviews the published evidence and the principal postulated mechanisms of action of intravenous immunoglobulins with special emphasis on inflammatory neuropathies.
Quantifying angular clustering in wide-area radio surveys

We quantify the angular clustering of radio galaxies in the NVSS and FIRST surveys using the two-point correlation function and the moments of counts-in-cells - both important points of comparison with theory. These investigations consistently demonstrate that the slope of the correlation function for radio galaxies agrees with that for optically selected galaxies, γ 1.8. We describe how to disentangle the imprint of galaxy clustering from the two observational problems: resolution of radio galaxies into multiple components and gradients in source surface density induced by difficulties in processing 'snapshot' radio observations (significant in both surveys below S 1 . 4 G H z ∼ 15 mJy). This study disagrees in some respects with previous analyses of the angular clustering of radio galaxies.
General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex

Calcium signaling represents the principle pathway by which astrocytes respond to neuronal activity. General anesthetics are routinely used in clinical practice to induce a sleep-like state, allowing otherwise painful procedures to be performed. Anesthetic drugs are thought to mainly target neurons in the brain and act by suppressing synaptic activity. However, the direct effect of general anesthesia on astrocyte signaling in awake animals has not previously been addressed. This is a critical issue, because calcium signaling may represent an essential mechanism through which astrocytes can modulate synaptic activity. In our study, we performed calcium imaging in awake head-restrained mice and found that three commonly used anesthetic combinations (ketamine/xylazine, isoflurane, and urethane) markedly suppressed calcium transients in neocortical astrocytes. Additionally, all three anesthetics masked potentially important features of the astrocyte calcium signals, such as synchronized widespread transients that appeared to be associated with arousal in awake animals. Notably, anesthesia affected calcium transients in both processes and soma and depressed spontaneous signals, as well as calcium responses, evoked by whisker stimulation or agonist application. We show that these calcium transients are inositol 1,4,5-triphosphate type 2 receptor (IP3R2)-dependent but resistant to a local blockade of glutamatergic or purinergic signaling. Finally, we found that doses of anesthesia insufficient to affect neuronal responses to whisker stimulation selectively suppressed astrocyte calcium signals. Taken together, these data suggest that general anesthesia may suppress astrocyte calcium signals independently of neuronal activity. We propose that these glial effects may constitute a nonneuronal mechanism for sedative action of anesthetic drugs.
EcoGene 3.0

EcoGene (http://ecogene.org) is a database and website devoted to continuously improving the structural and functional annotation of Escherichia coli K-12, one of the most well understood model organisms, represented by the MG1655(Seq) genome sequence and annotations. Major improvements to EcoGene in the past decade include (i) graphic presentations of genome map features; (ii) ability to design Boolean queries and Venn diagrams from EcoArray, EcoTopics or user-provided GeneSets; (iii) the genome-wide clone and deletion primer design tool, PrimerPairs; (iv) sequence searches using a customized EcoBLAST; (v) a Cross Reference table of synonymous gene and protein identifiers; (vi) proteome-wide indexing with GO terms; (vii) EcoTools access to >2000 complete bacterial genomes in EcoGene-RefSeq; (viii) establishment of a MySql relational database; and (ix) use of web content management systems. The biomedical literature is surveyed daily to provide citation and gene function updates. As of September 2012, the review of 37 397 abstracts and articles led to creation of 98 425 PubMed-Gene links and 5415 PubMed-Topic links. Annotation updates to Genbank U00096 are transmitted from EcoGene to NCBI. Experimental verifications include confirmation of a CTG start codon, pseudogene restoration and quality assurance of the Keio strain collection.
Bcl-2 Mitochondria That Involves Cytosolic Factor Regulated by Apoptotic Cytosol Facilitates Bax Translocation to Updated

Proapoptotic members of the Bcl-2 family, including Bax, Bak, and Bid, directly trigger the mitochondrial release of apoptogenic cytochromec and apoptosis-inducing factor into the cytoplasm. One of the crucial steps before Bax can exert its proapoptotic activity is translocation from the cytoplasm to the mitochondria, but the molecular mechanism of this translocation is not understood. To investigate the mechanism of apoptosis-associated Bax translocation, we used an i vitro system comprising isolated mitochondria and cytosol. We found that both endogenous and exogenous added recombinant Bax translocated to the mitochondria more efficiently in the presence of cytosol from cells with VP16-induced apoptosis than with cytoplasm from normal cells. This apoptosis-dependent promotion of Bax translocation was not seen with cytosol that was prepared from VP16-treated cells expressing Bcl-2. Cytosol from cells with VP16-induced apoptosis, but not that from normal cells or Bcl-2-expressing cells, induced cytochromec release from isolated mitochondria, which, as assessed by immunodepletion experiments, was mainly mediated by Bax. These results suggest that Bcl-2 exerts its antiapoptotic activity partly by inhibiting the translocation of Bax through the modification of cytosolic factors that are involved in such translocation during apoptosis.
Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cluster-randomised trial

Objective Preventive zinc supplementation in the form of tablets or syrup reduces the incidence of diarrhoea and acute lower respiratory tract infections (RTI), but its effect on malaria is inconsistent. When zinc is administered with other micronutrients or foods, its effect is also uncertain. We assessed the effects of different amounts and sources of zinc on the frequency of diarrhoea, malaria, fever and RTI in young children. Design, setting and populations This community-based, double-blind, placebo-controlled, cluster-randomised trial of 2435 children 9 months of age was carried out between April 2010 and July 2012 in rural southwestern Burkina Faso. Interventions Participants were randomly assigned at the concession level to receive daily 1 of 4 interventions for 9 months: (1) 20 g small-quantity lipid-based nutrient supplement (SQ-LNS) without zinc and placebo tablet, (2) 20 g SQ-LNS with 5 mg zinc and placebo tablet, (3) 20 g SQ-LNS with 10 mg zinc and placebo tablet or (4) 20 g SQ-LNS without zinc and 5 mg zinc tablet. Participants were visited weekly in their homes for morbidity surveillance for 9 months, and those with uncomplicated diarrhoea and malaria received treatment from the study field workers in the community. Main outcomes Incidence and longitudinal prevalence of diarrhoea, malaria, fever, and lower and upper RTI by intervention group. Results The incidence of diarrhoea, malaria and fever was 1.10 (±1.03 SD), 0.61 (±0.66 SD) and 1.49 (±1.12 SD) episodes per 100 child-days at risk, respectively, and did not differ by intervention group (p=0.589, p=0.856 and p=0.830, respectively). The longitudinal prevalence of acute lower RTI (0.1%; 95% IC 0.1–0.2%) and of upper RTI (7.8%; 95% IC 7.1–8.4%) did not differ among groups (p=0.234 and p=0.501, respectively). Conclusions Inclusion of 5 or 10 mg zinc in SQ-LNS and provision of 5 mg zinc dispersible tablet along with SQ-LNS had no impact on the incidence of diarrhoea, malaria and fever or the longitudinal prevalence of RTI compared with SQ-LNS without zinc in this population. Trial registration number NCT00944281.
Role of Cdc42-Cla4 Interaction in the Pheromone Response of Saccharomyces cerevisiae

ABSTRACT In Saccharomyces cerevisiae, the highly conserved Rho-type GTPase Cdc42 is essential for cell division and controls cellular development during mating and invasive growth. The role of Cdc42 in mating has been controversial, but a number of previous studies suggest that the GTPase controls the mitogen-activated protein (MAP) kinase cascade by activating the p21-activated protein kinase (PAK) Ste20. To further explore the role of Cdc42 in pheromone-stimulated signaling, we isolated novel alleles of CDC42 that confer resistance to pheromone. We find that in CDC42(V36A) and CDC42(V36A, I182T) mutant strains, the inability to undergo pheromone-induced cell cycle arrest correlates with reduced phosphorylation of the mating MAP kinases Fus3 and Kss1 and with a decrease in mating efficiency. Furthermore, Cdc42(V36A) and Cdc42(V36A, I182T) proteins show reduced interaction with the PAK Cla4 but not with Ste20. We also show that deletion of CLA4 in a CDC42(V36A, I182T) mutant strain suppresses pheromone resistance and that overexpression of CLA4 interferes with pheromone-induced cell cycle arrest and MAP kinase phosphorylation in CDC42 wild-type strains. Our data indicate that Cla4 has the potential to act as a negative regulator of the mating pathway and that this function of the PAK might be under control of Cdc42. In conclusion, our study suggests that control of pheromone signaling by Cdc42 not only depends on Ste20 but also involves interaction of the GTPase with Cla4.