Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiveness of Oral Bisphosphonates in Reducing Fracture Risk Among Oral Glucocorticoid Users: Three Matched Cohort Analyses

The benefit of oral bisphosphonates in reducing fracture risk in glucocorticoid‐induced osteoporosis is controversial. We aimed to estimate the effectiveness of oral bisphosphonates in reducing fracture risk in a cohort of new chronic oral glucocorticoid users. We created three matched cohorts using health care administrative data from Ontario, Canada. We included residents aged 66 years and older initiating chronic oral glucocorticoids (≥450 mg prednisone equivalent and ≥2 glucocorticoid prescriptions within a 6‐month window) between January 1998 and September 2014. Exposed patients were those who initiated an oral bisphosphonate (alendronate, etidronate, or risedronate) within the first 6 months of starting chronic oral glucocorticoid therapy. Exposed cohorts (3945 alendronate, 5825 risedronate, and 8464 etidronate) were each matched 1:1 to unexposed patients on glucocorticoid exposure, fracture risk factors, and propensity score. We examined incident hip (primary outcome), vertebral, forearm, and humerus fractures using Cox proportional hazard models. Alendronate (hazard ratio [HR] = 0.46, 95% confidence interval [CI] 0.25–0.80) and risedronate (HR = 0.58, 95% CI 0.36–0.90) were associated with reduced hip fracture risk. Alendronate (HR = 0.52, 95% CI 0.39–0.68), etidronate (HR = 0.59, 95% CI 0.48–0.73) and risedronate (HR = 0.47 95% CI 0.36–0.60) were associated with reduced vertebral fracture risk. No risk reduction in forearm or humerus fractures was apparent for any bisphosphonate. Among older chronic glucocorticoid initiators, all oral bisphosphonates reduced vertebral fracture risk, yet only alendronate and risedronate reduced hip fracture risk. Results were similar between men and women. We provided compelling evidence that early initiation of oral bisphosphonates during chronic oral glucocorticoid therapy is beneficial to prevent osteoporotic fractures. © 2017 American Society for Bone and Mineral Research.
Detecting Changes in the Environment Based on Full Posterior Distributions Over Real-Valued Grid Maps

To detect changes in an environment, one has to decide whether a set of recent observations is incompatible with a set of previous observations. For binary, lidar-based grid maps, this is essentially the case when the laser beam traverses a voxel that has been observed as occupied, or when the beam is reflected by a voxel that has been observed as empty. However, in real-world environments, some voxels are neither completely occupied nor completely free. These voxels have to be modeled by real-valued variables, whose estimation is an inherently statistical process. Thus, it is nontrivial to decide whether two sets of observations emerge from the same underlying true map values, and hence from an unchanged environment. Our main idea is to account for the statistical nature of the estimation by leveraging the full map posteriors instead of only the most likely maps. Closed-form solutions of posteriors over real-valued grid maps have been introduced recently. We leverage a similarity measure on these posteriors to score each point in time according to the probability that it constitutes a change in the hidden map value. While the proposed approach works for any type of real-valued grid map that allows the computation of the full posterior, we provide all formulas for the well-known reflection maps and the recently introduced decay-rate maps. We introduce and compare different similarity measures and show that our method significantly outperforms baseline approaches in simulated and real-world experiments.
Age as a Risk Factor in Abdominoplasty

Background: Recent studies reviewing large patient databases suggested that age may be an independent risk factor for abdominoplasty. However, these investigations by design considered only short‐term major complications. Objectives: The purpose of this investigation was: (1) to compare the safety of abdominoplasty in an elderly and younger patient population; (2) to determine the complication rates across all spectrums: major, minor, local, and systemic; and (3) to evaluate complications occurring both short and long term. Methods: Abdominoplasty procedures performed from 2010 to 2015 were retrospectively reviewed. Subjects were divided into two groups: ≤59 years old and ≥60 years old. Major, minor, local, and systemic complications were analyzed. Patient demographics, comorbidities, perioperative details, adjunctive procedures were also assessed. Results: A total of 129 patients were included in the study: 43 in the older and 86 in the younger age group. The median age of the elderly and young groups was 65.0 and 41.5 years, respectively (P < .001). No statistically significant differences in major, minor, local, or systemic complications were found when both age groups were compared. Major local, major systemic, minor local, and minor systemic in the elderly were 6.9%, 2.3%, 18.6%, and 2.3%, while in the younger patients were 9.3%, 4.7%, 10.5%, and 0.0%, respectively (P > .05). Median follow‐up time of the elderly (4.0 months) was no different than the younger (5.0 months) patients (P > .07). Median procedure time in the elderly (4.5 hours) was no different than the younger group (5.0 hours) (P = .4). The elderly exhibited a greater American Society of Anesthesiologist score, median body mass index (28.7 vs 25.1 kg/m2), and number of comorbidities (2.7 vs 0.9) (P < .001). Conclusions: There was no significant difference in either major or minor complications between the two groups. This suggests that with proper patient selection, abdominoplasty can be safely performed in the older age patient population. Level of Evidence: 2 Figure. No caption available.
The analysis of speed increase perspectives of nanostructuring burnishing with heat removal from the tool

The work deals with investigation of opportunities of speed increase of nanostructuring burnishing due to heat removal from the contact area of severe plastic deformation using friction via the tool. The work has analyzed changes of the structure, thickness and quality of the modified layer, while increasing treatment speed of the tool without heat removal and with heat-cooling system. It is established that the cooling system of the tool indenter with a cooling capacity of 10 W allows for the two-times increase of the critical speed of burnishing, and when exceeding this speed, the deformable material does not turn into a nanostructuring state. It is shown that heat removal provides for a stable maintenance of the indenter temperature, an increase in thickness of the nanostructured layer up to 5 μm and roughness up to Ra = 150 nanometers at processing speed up to 0.17 m/s.
NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

NGF has been implicated in forebrain neuroprotection from amyloidogenesis and Alzheimer's disease (AD). However, the underlying molecular mechanisms are still poorly understood. Here, we investigated the role of NGF signalling in the metabolism of amyloid precursor protein (APP) in forebrain neurons using primary cultures of septal neurons and acute septo‐hippocampal brain slices. In this study, we show that NGF controls the basal level of APP phosphorylation at Thr668 (T668) by downregulating the activity of the Ser/Thr kinase JNK(p54) through the Tyr kinase signalling adaptor SH2‐containing sequence C (ShcC). We also found that the specific NGF receptor, Tyr kinase A (TrkA), which is known to bind to APP, fails to interact with the fraction of APP molecules phosphorylated at T668 (APPpT668). Accordingly, the amount of TrkA bound to APP is significantly reduced in the hippocampus of ShcC KO mice and of patients with AD in which elevated APPpT668 levels are detected. NGF promotes TrkA binding to APP and APP trafficking to the Golgi, where APP–BACE interaction is hindered, finally resulting in reduced generation of sAPPβ, CTFβ and amyloid‐beta (1‐42). These results demonstrate that NGF signalling directly controls basal APP phosphorylation, subcellular localization and BACE cleavage, and pave the way for novel approaches specifically targeting ShcC signalling and/or the APP–TrkA interaction in AD therapy.
Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer

Background and objectives The dismal prognosis of gastric cancer patients is a global problem. We aim to evaluate the clinicopathologic features and prognostic factors of proximal and distal gastric cancer. Materials and methods Gastric cancer cases diagnosed and treated at the same surgical unit between 2007 and 2010 were reviewed. Follow-up data from all patients were collected for at least 5 years until 2015. A total of 964 patients were studied (distal gastric cancer [DG], n=777 and proximal gastric cancer [PG], n=187). Results DG patients had a relatively higher percentage of females, more thorough therapy (R0 [D0/D1/D2]), fewer combined organ resections, younger age, smaller tumors (<5 cm), shorter surgery durations, less blood loss during surgery, and a relatively lower percentage of nodal metastases and a TNM stage of 4 (p<0.05). A significantly higher 5-year survival rate was observed in DG patients compared to PG patients (DG: 51%, PG: 28%; p<0.001). A multivariate analysis demonstrated that tumor size, blood loss during surgery, surgery approach of lymph node dissection, treatment with palliative surgery, histopathologic type, TNM stage, and tumor location were independent predictors of poor outcome. Conclusion The different characteristics and prognosis of DG and PG cases have implications for the development of guiding strategies for a surgical program and assessment of prognosis of gastric cancer patients based on tumor location.
Significance of inflammation-based indices in the prognosis of patients with non-metastatic colorectal cancer

Previous studies demonstrated that several inflammation-based hematological indices are closely related to various malignancies, including colorectal cancer (CRC). In this study, the prognostic value of inflammation-based markers, including a combination index termed coNLR-PDW, comprising the preoperative neutrophil-to-lymphocyte ratio (NLR) and the platelet distribution width (PDW), was evaluated in 206 patients with non-metastatic CRC treated with surgery at a single medical center. The association of patient demographics, blood chemistry, and serum biochemical indices with recurrence-free survival (RFS) and overall survival (OS) were examined through univariate and multivariate analysis. Receiver operating characteristic curve analysis revealed the optimal cut-off values of the NLR and lymphocyte-to-monocyte ratio (LMR) to be, respectively, 2.0 and 3.32 for both RFS and OS. For PDW, cut-off values of 17.25% and 17.35% were defined for RFS and OS, respectively. On univariate analysis, lymph node involvement, stage, presence of intravascular emboli (IVE), carbohydrate antigen 199 (CA199) ≥ 35 kU/L, NLR ≥ 2.0, LMR ≤ 3.32, elevated PDW, a high coNLR-PDW score, high blood glucose, and high neutrophil and lymphocyte percentages correlated with poorer RFS and OS (P < 0.05). On multivariate analysis, lymph node involvement, IVE, CA199, PDW, and coNLR-PDW correlated with both RFS and OS (P < 0.05), while NLR correlated only with OS (P = 0.001). These results highlight the usefulness of the coNLR-PDW index as a prognostic marker of non-metastatic CRC outcome. In clinical practice, its assessment could contribute to establishing more personalized regimes for patients undergoing tumor resection surgery.
Optimizing Protein Intake and Nitrogen Balance (OPINiB) in Adult Critically Ill Patients: A Study Protocol for a Randomized Controlled Trial

Background Adequate nutrition of critically ill patients plays a key role in the modulation of metabolic response to stress. Objective This paper presents the development of a protocol for a randomized controlled trial (RCT) aimed at comparing clinical outcomes of patients in the intensive care unit (ICU) administered with standard and protein-fortified diet. Together with the RCT study protocol, the results of the observational analysis conducted to assess the feasibility of the RCT are presented. Methods An RCT on adult patients admitted to ICU and undergoing mechanical ventilation in the absence of renal or hepatic failure will be conducted. Patients enrolled will be randomized with an allocation rate of 1:1 at standard diet versus protein-fortified diet. The estimated sample size is 19 per arm, for a total of 38 patients to be randomized. Results Enrollment began in January 2017. In the feasibility study, 14 patients were enrolled. Protein administration increased significantly (P<.001) over time but was significantly lower compared to that recommended (P<.001). Blood urea nitrogen significantly increased (P<.03) over the period of observation. Such increased catabolism resulted in negative cumulative nitrogen balance (NB) in all patients, and some patients presented with a more negative NB compared to the others. Conclusions Results of the feasibility study clearly confirmed that protein provision in ICU patients is below that recommended and that this results in impaired NB. The emerging of an interindividual variability in NB will be further analyzed in the RCT. Trial Registration ClinicalTrials.gov NCT02990065; https://clinicaltrials.gov/ct2/show/NCT02990065 (Archived by WebCite at http://www.webcitation.org/6prsqZdRM).
HRTT: A Hierarchical Roof Topology Structure for Robust Building Roof Reconstruction from Point Clouds

The identification and representation of building roof topology are basic, but important, issues for 3D building model reconstruction from point clouds. Always, the roof topology is expressed by the roof topology graph (RTG), which stores the plane–plane adjacencies as graph edges. As the decision of the graph edges is often based on local statistics between adjacent planes, topology errors can be easily produced because of noise, lack of data, and resulting errors in pre-processing steps. In this work, the hierarchical roof topology tree (HRTT) is proposed, instead of traditional RTG, to represent the topology relationships among different roof elements. Building primitives or child structures are taken as inside tree nodes; thus, the plane–model and model–model relations can be well described and further exploited. Integral constraints and extra verifying procedures can also be easily introduced to improve the topology quality. As for the basic plane-to-plane adjacencies, we no longer decide all connections at the same time, but rather we decide the robust ones preferentially. Those robust connections will separate the whole model into simpler components step-by-step and produce the basic semantic information for the identification of ambiguous ones. In this way, the effects from structures of minor importance or spurious ridges can be limited to the building locale, while the common features can be detected integrally. Experiments on various data show that the proposed method can obviously improve the topology quality and produce more precise results. Compared with the RTG-based method, two topology quality indices increase from 80.9% and 79.8% to 89.4% and 88.2% in the test area. The integral model quality indices at the pixel level and the plane level also achieve the precision of 90.3% and 84.7%, accordingly.
Efficient Octree-Based Volumetric SLAM Supporting Signed-Distance and Occupancy Mapping

We present a dense volumetric simultaneous localisation and mapping (SLAM) framework that uses an octree representation for efficient fusion and rendering of either a truncated signed distance field (TSDF) or an occupancy map. The primary aim of this letter is to use one single representation of the environment that can be used not only for robot pose tracking and high-resolution mapping, but seamlessly for planning. We show that our highly efficient octree representation of space fits SLAM and planning purposes in a real-time control loop. In a comprehensive evaluation, we demonstrate dense SLAM accuracy and runtime performance on-par with flat hashing approaches when using TSDF-based maps, and considerable speed-ups when using occupancy mapping compared to standard occupancy maps frameworks. Our SLAM system can run at 10–40 Hz on a modern quadcore CPU, without the need for massive parallelization on a GPU. We, furthermore, demonstrate a probabilistic occupancy mapping as an alternative to TSDF mapping in dense SLAM and show its direct applicability to online motion planning, using the example of informed rapidly-exploring random trees (RRT$^*$).
Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients

Background Prolonged storage of packed red blood cells (PRBCs) may increase morbidity and mortality, and patients having massive transfusion might be especially susceptible. We therefore tested the hypothesis that prolonged storage increases mortality in patients receiving massive transfusion after trauma or nontrauma surgery. Secondarily, we considered the extent to which storage effects differ for trauma and nontrauma surgery. Methods We considered surgical patients given more than 10 units of PRBC within 24 hours and evaluated the relationship between mean PRBC storage duration and in-hospital mortality using multivariable logistic regression. Potential nonlinearities in the relationship were assessed via restricted cubic splines. The secondary hypothesis was evaluated by considering whether there was an interaction between the type of surgery (trauma versus nontrauma) and the effect of storage duration on outcomes. Results 305 patients were given a total of 8,046 units of PRBCs, with duration ranging from 8 to 36 days (mean ± SD: 22 ± 6 days). The odds ratio [95% confidence interval (CI)] for in-hospital mortality corresponding to a one-day in mean PRBC storage duration was 0.99 (0.95, 1.03, P = 0.77). The relationship did not differ for trauma and nontrauma patients (P = 0.75). Results were similar after adjusting for multiple potential confounders. Conclusions Mortality after massive blood transfusion was no worse in patients transfused with PRBC stored for long periods. Trauma and nontrauma patients did not differ in their susceptibility to prolonged PRBC storage.
Mechanical properties of plasma-hardened 5% chromium tool steel deposited by arc welding

A complex technology is proposed to increase the mechanical properties of tools, dies and machine components for hot work of metals. The combination of hardfacing with a 5% chromium deposited metal and subsequent surface treatment using a highly concentrated plasma jet creates a hard surface along with resistance to breakage upon impact. The extremely fine-grained martensite structure and relevant property gradients of the plasma-jet-hardened layer are almost identical to those treated by laser and electron beams. Due to rapid phase recrystallization, the dissolution of primary carbides and the saturation of a solid solution with carbon and alloying elements develop. This leads to an increase in the degree of tetragonality, microdistortions of the crystal structure and to an increase in hardness without a decrease in dynamic fracture toughness because of the high dislocation density and mosaic block size reduction. In its mechanical properties, martensitic 5% chromium (0.20% C) deposited metal after plasma hardening is close to chromium hot-work die steels, significantly surpassing them in dynamic frac-
Exploring opportunities to prevent cirrhosis admissions in the emergency department: A multicenter multidisciplinary survey

Patients with cirrhosis have high admission and readmission rates, and it is estimated that a quarter are potentially preventable. Little data are available regarding nonmedical factors impacting triage decisions in this patient population. This study sought to explore such factors as well as to determine provider perspectives on low‐acuity clinical presentations to the emergency department, including ascites and hepatic encephalopathy. A survey was distributed in four liver transplant centers to both emergency medicine and hepatology providers, who included attending physicians, house staff, and advanced practitioners; 196 surveys were returned (estimated response rate 50.6%). Emergency medicine providers identified several influential nonmedical factors impacting inpatient triage decisions, including input from a hepatologist (77.7%), inadequate patient access to outpatient specialty care (68.6%), and patient need for diagnostic testing for a procedure (65.6%). When given patient‐based scenarios of low‐acuity cases, such as ascites requiring paracentesis, only 7.0% believed patients should be hospitalized while 48.9% said these patients would be hospitalized at their institution (P < 0.0001). For mild hepatic encephalopathy, the comparable numbers were 19.5% and 55.2%, respectively (P < 0.001). Several perceived barriers were cited for this discrepancy, including limited resources both in the outpatient setting and emergency department. Most providers believed that an emergency department observation unit protocol would influence triage toward an emergency department observation unit visit instead of inpatient admission for both ascites requiring large volume paracentesis (83.2%) and mild hepatic encephalopathy (79.4%). Conclusion: Many nonmedical factors that influence inpatient triage for patients with cirrhosis could be targeted for quality improvement initiatives. In some scenarios, providers are limited by resource availability, which results in triage to an inpatient admission even when they believe this is not the most appropriate disposition. (Hepatology Communications 2018;2:237‐244)
Neuroprotective Effects of neuroEPO Using an In Vitro Model of Stroke

Erythropoietin (EPO) is a glycoprotein initially identified as a hormone synthesized and secreted by the kidney that regulates erythropoiesis. EPO, and a group of its derivatives, are being evaluated as possible neuroprotective agents in cerebral ischemia. The objective of this study, using an in vitro model, was to determine how neuroEPO—which is a variant of EPO with a low sialic acid content—protects neurons from the toxic action of glutamate. Primary neuronal cultures were obtained from the forebrains of Wistar rat embryos after 17 days of gestation. Excitotoxicity was induced after nine days of in vitro culture by treatment with a medium containing 100 µM glutamate for 15 min. After this time, a new medium containing 100 ng of neuroEPO/mL was added. Morphological cell change was assessed by phase-contrast microscopy. Oxidative stress was analysed by measuring antioxidant and oxidant activity. After 24 h, the treatment with 100 ng of neuroEPO/mL showed a significant (p < 0.01) decrease in mortality, compared to cells treated with glutamate alone. neuroEPO treatment decreased mortality and tended to reproduce the morphological characteristics of the control. The oxidative stress induced by glutamate is reduced after neuroEPO treatment. These results confirm that neuroEPO has a protective effect against neuronal damage induced by excitotoxicity, improving antioxidant activity in the neuron, and protecting it from oxidative stress.