Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Involvement on Observers' Estimates of Consensus, Distinctiveness, and Consistency

It was hypothesized that personal involvement affects actors' and observers' effort, ability, difficulty, and luck attributions. In addition, different involvement levels were expected to affect actors' and observers' consensus, distinctiveness, and consistency information estimates. Results partially confirm Kelley's attribution model. The findings support the notion that involvement is relevant to interpretations of actors' and observers' attribution differences and information inferences.
Hunter-gatherer genomic diversity suggests a southern African origin for modern humans

Africa is inferred to be the continent of origin for all modern human populations, but the details of human prehistory and evolution in Africa remain largely obscure owing to the complex histories of hundreds of distinct populations. We present data for more than 580,000 SNPs for several hunter-gatherer populations: the Hadza and Sandawe of Tanzania, and the ≠Khomani Bushmen of South Africa, including speakers of the nearly extinct N|u language. We find that African hunter-gatherer populations today remain highly differentiated, encompassing major components of variation that are not found in other African populations. Hunter-gatherer populations also tend to have the lowest levels of genome-wide linkage disequilibrium among 27 African populations. We analyzed geographic patterns of linkage disequilibrium and population differentiation, as measured by FST, in Africa. The observed patterns are consistent with an origin of modern humans in southern Africa rather than eastern Africa, as is generally assumed. Additionally, genetic variation in African hunter-gatherer populations has been significantly affected by interaction with farmers and herders over the past 5,000 y, through both severe population bottlenecks and sex-biased migration. However, African hunter-gatherer populations continue to maintain the highest levels of genetic diversity in the world.
A Meta-Analysis of Randomized Controlled Trials on Antiplatelet Agents Versus Placebo/Control for Treating Peripheral Artery Disease

Abstract Effect of aspirin (antiplatelet agents) in patients with peripheral artery disease (PAD) was still controversial. Varying studies reported varying results. Therefore, we did this meta-analysis to investigate if aspirin could reduce cardiovascular events in patients with PAD. A comprehensive literature search (PubMed, CCTR, Embase, Web of Science, CNKI, CBM-disc, and relevant websites) was conducted from 1990 to September 2014. The key search terms (“aspirin,” “PAD,” “peripheral arterial occlusive diseases,” and “claudication”) produced 9 high-quality randomized controlled trials (RCTs) of aspirin versus placebo/control. Mantel–Haenszel random-effects model was used to analysis of the 9 RCTs. The primary outcome was the cardiovascular events. Nine RCTs, composed of 9526 patients (4786 aspirin-treated and 4740 placebo or control-treated patients), were meta-analyzed. The results indicated that compared to placebo/control, aspirin could not significantly reduce the cardiovascular events (OR = 0.81, 95% CI = 0.56–1.15). Moreover, aspirin could not produce better effect on prevention of nonfatal myocardial infarction (OR = 0.98, 95% CI = 0.52–1.84), nonfatal stroke (OR = 0.89, 95% CI = 0.69–1.14), cardiovascular death (OR = 0.97, 95% CI = 0.68–1.38), any death (OR = 1.05, 95% CI = 0.85–1.30), and major bleeding (OR = 1.16, 95% CI = 0.82–1.65) than placebo/control. But aspirin, as monotherapy therapy, did significantly reduce the risk of nonfatal stroke (OR = 0.42, 95% CI = 0.21–0.84). Aspirin, as monotherapy or combination therapy, did not result in a significant decrease in the cardiovascular events. But aspirin, as monotherapy therapy, did significantly reduce the risk of nonfatal stroke. Our conclusion might help clinicians in clinical treating PAD. Future studies are needed to draw firm conclusions about the clinical benefit and risks of aspirin and other antiplatelet agents.
Resonance, Regulation and Revision: Rosen Method Meets the Growing Edge of Neurological Research

This article presents some of the recent research from the burgeoning field of neuroscience that supports what we do in Rosen Method Bodywork. Current neuroscience is confirming that deep listening, presence, and limbic resonance are powerful healing tools as they provide regulation and revision for human beings. The healing cascade of the human connection system, stimulated by the hormone oxytocin, regulates and revises our neurological health and our physiological functioning, modulating emotions, hormonal status, im- mune function, stability, and likely our fresh, creative thinking. Epigenetics, which says genes are not destiny, and brain plasticity, the ability of the brain to grow and change, may also be affected by Rosen Method touch. Turning off the fight/flight adrenaline system in the body and turning on this powerful physiological system of relationship, caring, and trust has far reaching implications for our physical and mental health and for our evolution as a species.
Time Travels: Time, Oral Histories and British-Polish Identities

In the research process, as in life generally, people construct their ethnic identity in different and changing ways. In this process, time is both a resource and a tool for construction. Looking at research into Polish communities in Britain, it is argued that time, far from being a measure of a pre-existing reality, is instead auto/biographically constructive of selves, identities and realities.
Developmental expression of the rat rod photoreceptor cGMP-gated cation channel

The appearance of cGMP-gated cation channel protein in the postnatal rat retina has been studied by fluorescence immunocytochemistry of radial retinal sections and immunoblots of retinal membrane proteins. Channel immunoreactivity was first detectable with RCNGC1-7H2 monoclonal antibody at postnatal day 7 (PN7) by both methods. Immunocytochemical label in retinal sections was localized to the outer segments, and immunoreactivity increased with increasing age. We also compared the developmental appearance of the cGMP-gated cation channel to that of other phototransduction proteins and developmental markers. RET-P2, a monoclonal antibody recognizing the 39-kDa rds/peripherin disc protein, first labeled outer segments at PN7, coincident with cGMP-gated cation channel expression. Double labeling of the same section of PN7 rat retina with RET-P2 and R309 (a polyclonal antiserum against the rod cGMP-gated cation channel) revealed identical patterns of labelling. Similarly, double labeling with RCNGC1-7H2 and an antibody against the rod cGMP-phosphodiesterase gave coincident labeling, suggesting coordinate expression mechanisms of phototransduction proteins with each other and with outer segment structural proteins.
Cytological Characterization of YpsB, a Novel Component of the Bacillus subtilis Divisome

ABSTRACT Cell division in bacteria is carried out by an elaborate molecular machine composed of more than a dozen proteins and known as the divisome. Here we describe the characterization of a new divisome protein in Bacillus subtilis called YpsB. Sequence comparisons and phylogentic analysis demonstrated that YpsB is a paralog of the division site selection protein DivIVA. YpsB is present in several gram-positive bacteria and likely originated from the duplication of a DivIVA-like gene in the last common ancestor of bacteria of the orders Bacillales and Lactobacillales. We used green fluorescent protein microscopy to determine that YpsB localizes to the divisome. Similarly to that for DivIVA, the recruitment of YpsB to the divisome requires late division proteins and occurs significantly after Z-ring formation. In contrast to DivIVA, however, YpsB is not retained at the newly formed cell poles after septation. Deletion analysis suggests that the N terminus of YpsB is required to target the protein to the divisome. The high similarity between the N termini of YpsB and DivIVA suggests that the same region is involved in the targeting of DivIVA. YpsB is not essential for septum formation and does not appear to play a role in septum positioning. However, a ypsB deletion has a synthetic effect when combined with a mutation in the cell division gene ftsA. Thus, we conclude that YpsB is a novel B. subtilis cell division protein whose function has diverged from that of its paralog DivIVA.
Genotype by environment interaction for 450-day weight of Nelore cattle analyzed by reaction norm models

Genotype by environment interactions (GEI) have attracted increasing attention in tropical breeding programs because of the variety of production systems involved. In this work, we assessed GEI in 450-day adjusted weight (W450) Nelore cattle from 366 Brazilian herds by comparing traditional univariate single-environment model analysis (UM) and random regression first order reaction norm models for six environmental variables: standard deviations of herd-year (RRMw) and herd-year-season-management (RRMw-m) groups for mean W450, standard deviations of herd-year (RRMg) and herd-year-season-management (RRMg-m) groups adjusted for 365-450 days weight gain (G450) averages, and two iterative algorithms using herd-year-season-management group solution estimates from a first RRMw-m and RRMg-m analysis (RRMITw-m and RRMITg-m, respectively). The RRM results showed similar tendencies in the variance components and heritability estimates along environmental gradient. Some of the variation among RRM estimates may have been related to the precision of the predictor and to correlations between environmental variables and the likely components of the weight trait. GEI, which was assessed by estimating the genetic correlation surfaces, had values < 0.5 between extreme environments in all models. Regression analyses showed that the correlation between the expected progeny differences for UM and the corresponding differences estimated by RRM was higher in intermediate and favorable environments than in unfavorable environments (p < 0.0001).
DIAGNOSTIC AND CONFIRMATION STRATEGIES IN TRAIT HYPOTHESIS TESTING

The role of diagnostic and confirmation strategies in trait hypothesis testing is examined. The present studies integrate theoretical and empirical work on qualitative differences among traits with the hypothesis-testing literature. Ss tested trait hypotheses from 2 hierarchically restrictive trait dimensions: introversion-extraversion and honesty-dishonesty. In Study 1, Ss generated questions to test trait hypotheses, and diagnosticity was theoretically defined (e.g., questions associated with nonrestrictive ends of trait dimensions). In Study 2, Ss selected questions from an experimenter-provided list in which diagnosticity was empirically denned. In Study 3, Ss chose between 2 equally diagnostic questions. In each of the studies, Ss showed a primary preference for diagnostic information and a secondary preference for confirmatory information. Ss' preference for diagnostic information suggests that they prefer to ask the most informative questions. The explanation for the confirmation bias is less obvious, and possible reasons for this effect are discussed. Many researchers within social psychology (eg., Snyder, 1981; Snyder & Campbell, 1980; Snyder & Swann, 1978; Swann & Giuliano, 1987; Trope & Bassok, 1982,1983; Trope, Bassok, & Alon, 1 984) have investigated the information-gathering strategies that lay interviewers use in testing trait hypotheses about other people (e.g., "Is Fred an extravert? ")- This research has revealed two major information-gathering strategies that subjects use when testing trait hypotheses: a confirmation strategy and a diagnostic strategy. However, there has been considerable debate within this literature regarding the relative importance of each strategy. The present research is designed to examine the role of both confirmation and diagnostic strategies in trait hypothesis testing.
A comparison of the effects of psychotomimetics and anxiolytics on punished and unpunished responding maintained by fixed interval schedules of food reinforcement in the rat

Characterization of anxiolytic drugs often employs conflict paradigms in which the drug effects on punished and unpunished responding can be compared. In this study, a fixed interval schedule generating a range of baseline response rates allowed comparison of the effects of anxiolytic drugs with those of psychotomimetic drugs on equivalent and differing rates of punished and unpunished responding. The first response made by the rat after a 40-s fixed interval elapsed resulted in food pellet delivery. In punished intervals, signalled by the illumination of stimulus lamps above each lever, a 0.6-mA shock was delivered after every 20th response, resulting in a lower rate of responding than that in the unpunished intervals. Three psychotomimetic agents, D-amphetamine, MK801 and DOI were compared with the anxiolytics chlordiazepoxide, NS2710 and pregabalin. The three psychotomimetics preferentially increased rates of unpunished responding compared with those of punished responding. Chlordiazepoxide, NS2710 and, to a lesser extent, pregabalin increased rates of both unpunished and punished responding. In comparison studies, yohimbine also increased rates of both unpunished and punished responding whereas the antidepressant citalopram had no effect. In conclusion, stable baseline performance over many months allowed the direct comparison of several different drugs in the same subjects with no need to adjust shock levels or equate baseline response rates. The drugs had systematic and replicable effects in this procedure, which, in the case of amphetamine and chlordiazepoxide, were similar to those in other species, and psychotomimetic drugs could clearly be distinguished from anxiolytic drugs. The procedure, however, has limited value for characterizing novel anxiolytic agents as the examples used here increased punished and unpunished responding to the same extent, and were indistinguishable in that regard from the clinically anxiogenic agent, yohimbine.
Intuition in clinical decision-making: a psychological penumbra.

AIM To demonstrate the link between intuition and cognitive as well as physiological processes as a way of helping to explain how intuition plays a part in complex decision-making. BACKGROUND Over the years, numerous debates and discussions have raged about how intuition contributes to the making of complex clinical decisions. Intuition continues to be poorly understood, and in some cases, it is still considered the work of our sixth sense. Although experts make accurate intuitive decisions, they are not always able to articulate how they have arrived at a particular decision. METHOD We use two scientific experiments to demonstrate how research has helped to explain the cognitive and physiological functions of intuition in relation to complex decision-making. We discuss the role of unconscious thought in intuitive decision-making. Finally, we show that intuition can be a valuable component of expert practice. CONCLUSION Intuition has traceable cognitive and physiological bases that help us understand how we use it as a basis for making complex clinical decisions. Experts, especially those working in acute and palliative care, where there are difficult ethical as well as clinical patients situations, can benefit from using intuitive ideas to arrive at complex decisions.
Is the relationship between lifestyle factors and physical activity mediated by psychological needs and motivation?

In general, participating in activities for self-determined reasons (i.e. because you “want to” engage in the activity) results in stronger levels of motivation that last longer than participating for more controlled forms of motivation (i.e. because you feel you “have to” participate). As having unsatisfied physical needs through drinking alcohol, eating poorly, and sleeping little or less consistently may interrupt self-determined forms of motivation for physical activity, we hypothesised that basic psychological needs satisfaction and self-determined motivation would mediate the lifestyle–leisure-time physical activity (LTPA) relationship. Undergraduate college students (N = 887) completed an on-line survey assessing food consumption, alcohol use, sleep patterns, basic need satisfaction, self-determined motivation, and level of LTPA. Eating breakfast more regularly, eating more fruit and vegetables, sleeping earlier in the night, and staying up later on weekends than weeknights were associated with higher LTPA levels and these effects were mediated through psychological variables. In contrast, eating more carbohydrates and dairy and drinking more alcohol directly associated with LTPA, but not through the proposed psychological mediators. Results support the link between physical and psychological factors promoting LTPA, identify those lifestyle choices that most closely relate to psychological need satisfaction and self-determined motivation, and encourage searches for other possible mediators for linking dairy and carbohydrate intake and alcohol use with LTPA.
Sleep disturbances in Swedish pre-school children and their parents

The sleeping behaviour of 378 children between 5 and 6 years of age was examined by means of questionnaires filled out by the parents. In 26.9% of the children at least one of the following sleep problems was reported: difficulties initiating sleep, night awakenings, or respiratory difficulties during sleep. The children with sleep problems had significantly more reports of other current sleep-wake difficulties and of sleep problems during earlier ages. The parents, 367 mothers and 273 fathers, also answered questions about their own sleep-wake complaints. Twenty-two percent of the mothers and 12% of the fathers reported increased sleeping difficulties after becoming a parent. In these mothers early morning awakenings, not feeling rested in the morning, and daytime sleepiness were most prominent. The corresponding group of fathers was characterized by difficulty initiating sleep, night awakenings, and not feeling rested in the morning. The mothers and fathers who reported sleep problems in their children .
Authenticated Key Establishment Protocols for a Home Health Care System

Wireless sensor networks provide solutions to a range of monitoring problems. However, they also introduce a new set of problems mainly due to small memories, weak processors, limited energy and small packet size. Thus only a very few conventional protocols can readily be used in sensor networks. Sensor networks can exist in many different environments, and each environment has its own unique characteristics and requirements. As an example application, a home health care system is proposed and examined in detail in this paper. We show how cryptographically weak physiological data can be used to establish keys between body sensors, where the sensors have no other prior secret. This paper also proposes a protocol where a hand held device, such as a PDA, can establish a key with the majority of sensors found in our home health care system. This is achieved without the necessity of using traditional encryption. Detailed analysis of each of the protocols is provided. The protocols were implemented in TinyOS and simulated using TOSSIM and ATEMU. Energy consumption and memory requirements are analysed and it was found that an RSA implementation of our protocols has some advantages over an ECC implementation.
FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype

Fragile X mental retardation protein (FMRP) is absent or highly reduced in Fragile X Syndrome, a genetic disorder causing cognitive impairment and autistic behaviors. Previous proof-of-principle studies have demonstrated that restoring FMRP in the brain using viral vectors can improve pathological abnormalities in mouse models of fragile X. However, unlike small molecule drugs where the dose can readily be adjusted during treatment, viral vector–based biological therapeutic drugs present challenges in terms of achieving optimal dosing and expression levels. The objective of this study was to investigate the consequences of expressing varying levels of FMRP selectively in neurons of Fmr1 knockout and wild-type (WT) mice. A wide range of neuronal FMRP transgene levels was achieved in individual mice after intra-cerebroventricular administration of adeno-associated viral vectors coding for FMRP. In all treated knockout mice, prominent FMRP transgene expression was observed in forebrain structures, whereas lower levels were present in more caudal regions of the brain. Reduced levels of the synaptic protein PSD-95, elevated levels of the transcriptional modulator MeCP2, and abnormal motor activity, anxiety, and acoustic startle responses in Fmr1 knockout mice were fully or partially rescued after expression of FMRP at about 35–115% of WT expression, depending on the brain region examined. In the WT mouse, moderate FMRP over-expression of up to about twofold had little or no effect on PSD-95 and MeCP2 levels or on behavioral endophenotypes. In contrast, excessive over-expression in the Fmr1 knockout mouse forebrain (approximately 2.5–6-fold over WT) induced pathological motor hyperactivity and suppressed the startle response relative to WT mice. These results delineate a range of FMRP expression levels in the central nervous system that confer phenotypic improvement in fragile X mice. Collectively, these findings are pertinent to the development of long-term curative gene therapy strategies for treating Fragile X Syndrome and other neurodevelopmental disorders.
Efficacy and Safety of the Sigma Receptor Ligand EMD 57445 (Panamesine) in Patients with Schizophrenia: an Open Clinical Trial

EMD 57455 (panamesine) is a new sigma receptor ligand alleged to have antipsychotic effects. Animal studies have demonstrated that EMD 57445 has a functional antidopaminergic activity without extrapyramidal side effects and a c-fos expression pattern similar to that obtained with atypical neuroleptics. Therefore, the substance might be of interest for the treatment of schizophrenia. The present article describes the results of an exploratory open clinical trial that was aimed at determining the appropriate dose range for clinical efficacy and safety of EMD 57455 in patients with an acute episode of schizophrenia. In a treatment period of 4 weeks, 12 patients received EMD 57445 up to 60 mg/day for 4 weeks. Seven patients completed the study: four were classified as responders (as defined by at least a 50% decrease in the BPRS total score), two improved slightly and one patient remained unimproved. The intent-to-treat analysis showed significant improvement in the psychometric variables assessed by the Brief Psychiatric Rating Scale, Clinical Global Impression and Positive and Negative Symptoms Scale. Major side effects were extrapyramidal symptoms in two patients and restlessness in one patient. With respect to efficacy and safety, our data agree with a previous study, except that in our study EMD 57455 was not totally free of extrapyramidal side effects.