Miracle-dz/UniFAR-FTUs huggingface dataset:
Implementing Competency-Based Education: Challenges, Strategies, and a Decision-Making Framework

Abstract The number of competency-based education (CBE) degree programs has increased rapidly over the past five years, yet there is little research on CBE program development. This study utilized conceptual models of higher education change and a qualitative methodology to analyze the strategies and challenges in implementing CBE business degree programs at three universities. The findings were generally consistent with the constructs in the higher education change models. Important issues not highlighted in the models nor in previous CBE research included the long-run impact of initial institutional structure decisions; the trade-off between cost and quality; the interaction among program flexibility, student characteristics, and faculty interaction; the importance of feedback loops for quality assurance; and variation in alignment with traditional programs. The findings were used to generate a preliminary framework for decision making that educational leaders can use in implementing CBE programs.
Memory persistency

Emerging nonvolatile memory technologies (NVRAM) promise the performance of DRAM with the persistence of disk. However, constraining NVRAM write order, necessary to ensure recovery correctness, limits NVRAM write concurrency and degrades throughput. We require new memory interfaces to minimally describe write constraints and allow high performance and high concurrency data structures. These goals strongly resemble memory consistency. Whereas memory consistency concerns the order that memory operations are observed between numerous processors, persistent memory systems must constrain the order that writes occur with respect to failure. We introduce memory persistency, a new approach to designing persistent memory interfaces, building on memory consistency. Similar to memory consistency, memory persistency models may be relaxed to improve performance. We describe the design space of memory persistency and desirable features that such a memory system requires. Finally, we introduce several memory persistency models and evaluate their ability to expose NVRAM write concurrency using two implementations of a persistent queue. Our results show that relaxed persistency models accelerate system throughput 30-fold by reducing NVRAM write constraints.
Consumer Complaints and Company Market Value

Consumer complaints affect company market value and common sense suggests that a negative impact is expected. However, do complaints always negatively impact company market value? We hypothesize in this study that complaints may have a non-linear effect on market value. Positive (e.g. avoiding high costs to solve complaints) and negative (e.g. speedy and intense diffusion) tradeoffs may occur given the level of complaints. To test our non-linear hypothesis, a panel data was collected from cell phone service providers from 2005 to 2013. The results supported our tradeoff rationale. Low levels of complaints allow for companies to increase market value, while high levels of complaints cause increasing harm to market value. The sample, model and period considered in this study, indicates a level of 0.49 complaints per thousand consumers as the threshold for a shift in tradeoffs. The effects on market value become increasingly negative when trying to make reductions to move below this level, due to negative tradeoffs.
BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas

In a previous study we demonstrated high expression of the non‐coding BIC gene in the vast majority of Hodgkin's lymphomas (HLs). Evidence suggesting that BIC is a primary microRNA transcript containing the mature microRNA‐155 (miR‐155) as part of a RNA hairpin is now accumulating. We therefore analysed HL cell lines and tissue samples to determine whether miR‐155 is also expressed in HL. High levels of miR‐155 could be demonstrated, indicating that BIC is processed into a microRNA in HL. Most non‐HL subtypes were negative for BIC as determined by RNA‐ISH. However, in diffuse large B cell lymphoma (DLBCL) and primary mediastinal B cell lymphoma (PMBL), significant percentages of positive tumour cells were observed in 12/18 and 8/8 cases. A higher proportion of tumour cells were positive for BIC in DLBCL with activated B cell‐like phenotype than in DLBCL with germinal centre B cell‐like phenotype. Differential BIC expression was confirmed by qRT‐PCR analysis. Northern blot analysis showed expression of miR‐155 in all DLBCL and PMBL derived cell lines and tissue samples analysed. In summary, we demonstrate expression of primary microRNA BIC and its derivative miR‐155 in HL, PMBL and DLBCL. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Development and Validation of a 3-Plex RT-qPCR Assay for the Simultaneous Detection and Quantitation of the Three PML-RARa Fusion Transcripts in Acute Promyelocytic Leukemia

Rapid diagnosis of acute promyelocytic leukemia (APL) with promyelocytic leukemia-retinoic acid receptor alpha (PML-RARa) contributes to a highly effective therapy with all-trans retinoic acid (ATRA). Real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) is a valuable tool to diagnose APL with PML-RARa. However, a single RT-qPCR analysis, which is laborious and costly, has to be performed in three reactions to determine whether one of the three PML-RARa transcripts is present and to quantify the involved transcript. This paper describes a novel TaqMan MGB probe-based 3-plex RT-qPCR assay in a single reaction to detect simultaneously the three PML-RARa transcripts. Specific primers and probe were designed, and the results were further normalized to the Abelson gene. The detection results for the serially diluted plasmid indicate that the analytical sensitivity was 10 copies per reaction for PML-RARa bcr1, bcr2, and bcr3. A relatively high sensitivity of 10-4 was achieved with this assay when analyzing the bcr1 transcripts obtained from the NB4 cell line. The reproducibility was satisfactory because the coefficients of variation of cycle threshold values were less than 3% for both inter- and intra-assays. After testing 319 newly diagnosed patients with leukemia (including 61 APL cases), the results of the 3-plex RT-qPCR assay completely agreed with the traditional methods used for the detection of PML-RARa. The quantitative results of the 3-plex RT-qPCR were highly correlated with the single RT-qPCR and showed similar assay sensitivity for 60 PML-RARa positive APL samples at diagnosis and 199 samples from 57 patients during follow-up. Interestingly, one PML-RARa bcr2 case at diagnosis with breakpoint at 1579, which was not detected by the single RT-q-PCR, was detected by the 3-plex RT-qPCR assay. The 3-plex RT-qPCR assay is a specific, sensitive, stable, and cost-effective method that can be used for the rapid diagnosis and treatment monitoring of APL with PML-RARa.
Perceived Working Conditions and Sickness Absence - A Four-year Follow-up in the Food Industry

Objectives To analyze the association between changes in perceived physical and psychosocial working conditions and change of sickness absence days in younger and older (< 50 and ≥ 50 years) food industry employees. Methods This was a follow up study of 679 employees, who completed working conditions survey questionnaires in 2005 and 2009 and for whom the requisite sickness absence data were available for the years 2004 and 2008. Results Sickness absence increased and working conditions improved during follow-up. However, the change of increased sickness absence days were associated with the change of increased poor working postures and the change of deteriorated team spirit and reactivity (especially among < 50 years). No other changes in working conditions were associated with the changes in sickness absence. Conclusion Sickness absence is affected by many factors other than working conditions. Nevertheless, according to this study improving team spirit and reactivity and preventing poor working postures are important in decreasing sickness absence.
Licensed under Creative Commons Attribution Cc by Relationship between Music Preference and Personality Type

Music is universally omnipresent and in contemporary society, music is so pervasive that it is absolutely unavoidable. The deliberate access of FM radios in cars, iPods, smart phones and speaker systems has made music potentially ubiquitous to the individual. It is believed that the average person to listens to music 10 to 15 percent of the day. And importantly this percentage is approximately equal to the time spent watching television or reading books, and about half the time spent in daily conversation Because of the omnipresence of music, the amount of time and money spent consuming music, and its role in communicating one's personal image, it deserves to be well studied in combination with personality and individual preferences (Rentfrow, & Gosling, 2003, p. 1236).
Tuning the dials of Synthetic Biology

Synthetic Biology is the ‘Engineering of Biology’ – it aims to use a forward-engineering design cycle based on specifications, modelling, analysis, experimental implementation, testing and validation to modify natural or design new, synthetic biology systems so that they behave in a predictable fashion. Motivated by the need for truly plug-and-play synthetic biological components, we present a comprehensive review of ways in which the various parts of a biological system can be modified systematically. In particular, we review the list of ‘dials’ that are available to the designer and discuss how they can be modelled, tuned and implemented. The dials are categorized according to whether they operate at the global, transcriptional, translational or post-translational level and the resolution that they operate at. We end this review with a discussion on the relative advantages and disadvantages of some dials over others.
CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway

The Apo-1/Fas antigen (CD95) mediates programmed cell death of lymphocytes when bound by Fas ligand or anti-Apo-1/Fas antibody. In contrast, the CD40 antigen provides a potent activation and survival signal to B lymphocytes when it is engaged by its T cell ligand (CD40L, gp39) or cross-linked by anti-CD40 antibody. In this study, we use human tonsillar B cells and the Ramos Burkitt's lymphoma B cell line, which serves as a model for human germinal center B lymphocytes, to study the effectors of Apo-1/Fas expression and apoptosis of human B cells. We found that Apo-1/Fas expression was upregulated on both malignant and normal human B lymphocytes after CD40 ligation induced by (a) cognate T helper-B cell interaction mediated by microbial superantigen (SAg); (b) contact-dependent interaction with CD40L+, but not CD40L- Jurkat mutant T cell clones; and (c) monoclonal anti-CD40, but not any of a panel of control antibodies. Enhanced B cell Fas/Apo-1 expression is functionally significant. Coculture of Ramos Burkitt's lymphoma line cells with irradiated SAg-reactive CD4+ T cells with SAg or CD40L+ Jurkat T cells results in B cell apoptosis, evidenced by reduced cell viability and DNA laddering. This process is augmented by the addition of anti-Apo-1/Fas monoclonal antibody, consistent with an acquired susceptibility to Apo-1/Fas-mediated apoptosis. These data support an immunoregulatory pathway in which seemingly contradictory signals involving the B cell proliferation/survival antigen CD40, as well as the Apo-1/Fas molecule, which mediates programmed cell death of lymphocytes, are linked in the process of human B cell activation.
Physiological Pharmacokinetic Analysis Using Population Modeling and Informative Prior Distributions

Abstract We describe a general approach using Bayesian analysis for the estimation of parameters in physiological pharmacokinetic models. The chief statistical difficulty in estimation with these models is that any physiological model that is even approximately realistic will have a large number of parameters, often comparable to the number of observations in a typical pharmacokinetic experiment (e.g., 28 measurements and 15 parameters for each subject). In addition, the parameters are generally poorly identified, akin to the well-known ill-conditioned problem of estimating a mixture of declining exponentials. Our modeling includes (a) hierarchical population modeling, which allows partial pooling of information among different experimental subjects; (b) a pharmacokinetic model including compartments for well-perfused tissues, poorly perfused tissues, fat, and the liver; and (c) informative prior distributions for population parameters, which is possible because the parameters represent real physiological.
Morphology and Histology of Lyonet's Gland of the Tropical Tasar Silkworm, Antheraea mylitta

Abstract The morphology and histology of Lyonet's gland in the second to fifth instar larvae of Antheraea mylitta Drury (Lepidoptera: Saturniidae) are described. Each of the paired silk glands of this silk worm were associated with a Lyonet's gland. The paired Lyonet's glands were located on the ventrolateral sides of the esophagus, close to the subesophageal ganglion. Whole mount and SEM observations revealed that each Lyonet's gland consisted of a rosette of glandular mass, and a short narrow tubular duct opening into the anterior part of the silk gland (ASG), close to the common excretory duct. In each instar, these glands were unequal in size. The glandular mass was innervated by fine nerves from the subesophageal ganglion, suggesting a neural control for the glandular activity. The glandular mass was made up of clustered long cells wrapped by a thin basal lamina, which was continuous over the non-secretory low columnar cells of the Lyonet's gland duct and ASG. The narrow bases of long cells of each glandular mass led into the lumen of the duct of the gland. Histochemical analysis of fully developed Lyonet's gland showed clustered lipid granules in the gland cells.
Neurophysiological Correlates of Self-monitoring Differentially Moderate the Relation Between Maternal Depression and Children's Behaviour Problems

Research in developmental psychopathology has advanced our understanding of emotional dysregulation underlying children’s behavioural problems and their association with maternal depression. Neurophysiological measures may further clarify these relations. The ERN (errorrelated negativity) is an event-related potential commonly used to assess self-monitoring, with large amplitudes reflecting internalizing and small amplitudes reflecting externalizing symptoms. The present study investigated the effect of ERN amplitude on the relation between maternal depression and internalizing and externalizing problems in a sample of children referred for aggressive behaviour. ERN amplitudes were recorded while 50 children (8-10 years of age) engaged in a go/no-go emotion induction task. Results indicated an association between high ERN amplitudes and internalizing behaviour and between small ERN amplitudes and externalizing behaviours for children with depressed mothers. These findings suggest that the degree of self-monitoring (indexed by ERN amplitude) moderates the relation between maternal depression and psychopathological outcomes in children.
Interaction Effects of Arousal Level of Positive Ambient Emotion and Advertisement Type on Product Evaluation

The purpose of this study is to show that the effectiveness of utilitarian versus hedonic attributefocused advertisement on product evaluation depends on the arousal level of positive emotion, and to explore mediation effect of cognitive response to utilitarian attribute-focused advertisement and affective response to hedonic attribute-focused advertisement on the effectiveness of utilitarian versus hedonic attribute-focused advertisement. This research employs a 2 (arousal level: mild vs. elevated) × 2 (advertisement type: utilitarian vs. hedonic) between-subjects design, and 200 undergraduate students participate in the experiment, in which there are 50 students at each experimental group. The results of ANCOVA with positive emotion level as a covariate on advertised product evaluation show significant interaction effect of arousal level and advertisement type, and no effect of positive emotional level. Both of the mediation effects of the cognitive response and those of the affective response are significant. Participants under mild (elevated) arousal of positive emotion more positively evaluate the product in utilitarian (hedonic) attribute-focused advertisement. The positive effect of utilitarian (hedonic) attributefocused advertisement on product evaluation is partially mediated by cognitive (affective) response to the advertisement when consumers are under the mild (elevated) arousal of positive emotion. The results of this study show that advertisers should use utilitarian (hedonic) attribute-focused advertisement to consumers under the mild (elevated) arousal of ambient positive emotion, which should be searched by exploring what kind of event they have experienced.
Semantic interoperability in the securities industry: context interchange mediation of semantic differences in enumerated data types

Using securities industry examples, the context interchange mediation knowledge architecture is applied to interoperability problems for enumerated data types, such as codes and other symbols used to represent conceptual distinctions. Ongoing efforts in the securities industry to develop new XML-based standards for information interchange are examined. Using components representing similar securities information, drawn from different but complementary securities standards and sources, example problems of information interoperability are examined. We show that transforming data representation into an autonomously specified context model and thence into a general domain ontology allows successful interoperability in several ways depending on how each context is explained to the mediator.
Digital and Mixed Signal Testing Technology the Standards IEEE 1149 . 1 and IEEE 1149 . 4

Among all the On-Chip built-in self-test (BIST) technologies, JTAG is the most well-known and widely used. In this paper, the mechanism of basic JTAG (IEEE 1149.1) has been discussed. The pitfalls of the method are also discussed, some of which are rectified in the future standard, IEEE 1149.4 for Mixed Signal testing, which is also described here. Many of the valuable research papers on these standards are analyzed. KeywordsIEEE 1149.1, IEEE 1149.4, JTAG, Boundary Scan, BSDL, Mixed Signal, SoC.
RESPONSE OF CULTURED MACROPHAGES TO MYCOBACTERIUM TUBERCULOSIS, WITH OBSERVATIONS ON FUSION OF LYSOSOMES WITH PHAGOSOMES

The cytological response to the ingestion of tubercle bacilli by cultured mouse peritoneal macrophages has been studied by electron microscopy. Methods included a quantitative assessment based on systematic surveying of cell profiles, and of phagosomes and their contained bacteria, encountered in thin sections; classification of the sectioned bacteria into visibly damaged and apparently intact categories; prelabeling of dense granules (secondary lysosomes) with ferritin as an aid to identifying the occurrence and frequency of phagosome-lysosome fusion; and monitoring of bacterial growth and viability by light microscopy and cultural counts. The situations studied were as follows: progressive infection with the multiplying virulent strain H37Rv; ingestion of the same strain previously inactivated by gamma radiation; infection with an attenuated strain (BCG); and a stabilized virulent infection induced by the surfactant Macrocyclon. In the bacterial suspensions used routinely for inoculation, about half the bacilli were viable, matching closely the proportions of intact and damaged organisms identified with the electron microscope. In the inoculated macrophages, some phagosomes containing intact bacilli and others containing damaged bacilli were always to be found; but the proportion of organisms scored as damaged increased, and that of intact organisms decreased, in situations where the population as a whole had been rendered nonviable before inoculation, or where they became so intracellularly as in the late stages of a BCG infection. Evidence of fusion of ferritin-marked lysosomes with some bacterium-containing phagosomes was obtained in all experiments, but a significant difference was regularly observed according to whether the bacilli were damaged or intact. Virtually all phagosomes containing damaged bacilli showed signs of fusion; but when many phagosomes were present containing apparently intact organisms (as with actively multiplying strain H37Rv or with this strain held at a steady level of viability by Macrocyclon, and also with strain BCG at an early stage of that infection), signs of fusion of lysosomes with these phagosomes were infrequent. From these findings it is inferred that intracellular survival of M. tuberculosis in cultured macrophages is associated with a tendency to nonfusion of dense granules with the phagosome, thus avoiding direct exposure of the bacilli to the contents of these organelles. It is suggested, further, that fusion of dense granules with the phagosome, leading to digestion, is determined by recognition of the bacillus as nonviable. The possibility is discussed that the cytological response to different mycobacterial infections may reflect differences of a basic nature between facultative and obligate intracellular parasitism.
A stochastic particle method for the McKean-Vlasov and the Burgers equation

In this paper we introduce and analyze a stochastic particle method for the McKean-Vlasov and the Burgers equation; the construction and error analysis are based upon the theory of the propagation of chaos for interacting particle systems. Our objective is three-fold. First, we consider a McKean-Vlasov equation in [0,T] x R with sufficiently smooth kernels, and the PDEs giving the distribution function and the density of the measure μ t , the solution to the McKean-Vlasov equation. The simulation of the stochastic system with N particles provides a discrete measure which approximates μkΔt for each time kΔt (where Δt is a discretization step of the time interval [0, T]). An integration (resp. smoothing) of this discrete measure provides approximations of the distribution function (resp. density) of μkΔt. We show that the convergence rate is O (1/√N+ for the approximation in L i (Ω x R) of the cumulative distribution function at time T, and of order O (e 2 +1/e) (1/√N + √Δt for the approximation in L l (Ω x R) of the density at time T (Ω is the underlying probability space, e is a smoothing parameter). Our second objective is to show that our particle method can be modified to solve the Burgers equation with a nonmonotonic initial condition, without modifying the convergence rate O (1/√N+√Δt). This part extends earlier work of ours, where we have limited ourselves to monotonic initial conditions. Finally, we present numerical experiments which confirm our theoretical estimates and illustrate the numerical efficiency of the method when the viscosity coefficient is very small.