Miracle-dz/UniFAR-FTUs huggingface dataset:
An App a Day Keeps the Doctor Away: Guided Education and Training via Smartphones in Subthreshold Post Traumatic Stress Disorder

Post traumatic stress disorder (PTSD) symptoms are common in military service members (SMs), but stigma can impede treatment initiation. Smartphone applications (apps) are available anywhere, anytime, with the potential to both mitigate the impact of stigma and reduce PTSD symptom severity. We provided 144 SMs or family members, with subthreshold PTSD symptoms (PTSD Checklist [PCL] scores of 28-49), with apps promoting psychoeducation, social engagement, and relaxation and randomized them to 6 weeks of resilience enhancement (brief cognitive-behavioral session, followed by daily text messages directing app use) or a control group (daily text messages of inspirational quotes). Participants (54 percent males, 87 percent SMs) in both groups reported reductions in PTSD, anxiety, and depression symptoms during the 6-week intervention, which were sustained at 3 months, but exhibited partial rebound at 6-12 months. Our preliminary results suggest that app use, with or without specific direction, feasibly and effectively reduces symptom severity. Future studies should consider a longer intervention, enhanced compliance tracking, or boosters to sustain benefits.
Astroglial transcriptome dysregulation in early disease of an ALS mutant SOD1 mouse model

Abstract Astroglia are a morphologically diverse and highly abundant cell type in the CNS. Despite these obvious observations, astroglia still remain largely uncharacterized at the cellular and molecular level. In disease contexts such as amyotrophic lateral sclerosis (ALS), it has been widely shown that astroglia downregulate crucial physiological functions, become hypertrophied, reactive, and toxic to motor neurons. However, little is known about the astroglia-specific transcriptomic changes that occur during ALS disease progression, especially early in disease. To address this, we FACS-isolated pure astroglia from early and mid-symptomatic superoxide dismutase 1 (SOD1) G93A spinal cord and performed microarray sequencing, in hopes to uncover markers and pathways driving astroglia dysfunction in ALS. After extensive analyses, we uncovered genes selectively enriched and downregulated in both control and SOD1 astroglia at both disease points. In addition, we were able to identify genes and pathways differentially expressed that may have relevance with other neurodegenerative diseases, such as Parkinson’s and Alzheimer’s disease, suggesting a common theme among astroglial dysfunction in neurodegenerative disease. In aggregate, this study sheds light on the common and unique themes of dysfunction that astroglia undergo during neurodegenerative disease progression and provides candidate targets for therapeutic approaches.
Properties of an R Factor Which Originated in Pseudomonas aeruginosa 1822

RP1, a group of genes specifying resistance to carbenicillin, neomycin, kanamycin, and tetracycline and originating in a strain of Pseudomonas aeruginosa, was freely transmissible between strains of P. aeruginosa, Escherichia coli, and Proteus mirabilis. Acquisition of the multiple drug resistance specified by RP1 by these strains was accompanied by acquisition of an extrachromosomal satellite of covalently closed circular deoxyribonucleic acid of molecular weight about 40 million daltons and of buoyant density 1.719 g/cm3 (60% guanine plus cytosine).
Racial differences in the evaluation of pediatric fractures for physical abuse.

CONTEXT Child maltreatment is a significant problem within US society, and minority children have higher rates of substantiated maltreatment than do white children. However, it is unclear whether minority children are abused more frequently than whites or whether their cases are more likely to be reported. OBJECTIVES To determine whether there are racial differences in the evaluation and Child Protective Services (CPS) reporting of young children hospitalized for fractures. DESIGN, SETTING, AND PATIENTS Retrospective chart review conducted at an urban US academic children's hospital among 388 children younger than 3 years hospitalized for treatment of an acute primary skull or long-bone fracture between 1994 and 2000. Children with perpetrator-admitted child abuse, metabolic bone disease, birth trauma, or injury caused by vehicular crash were excluded. MAIN OUTCOME MEASURES Ordering of skeletal surveys and filing reports of suspected abuse. RESULTS Reports of suspected abuse were filed for 22.5% of white and 52.9% of minority children (P<.001). Abusive injuries, as determined by expert review, were more common among minority children than among white children (27.6% vs 12.5%; P<.001). Minority children aged at least 12 months to 3 years (toddlers) were significantly more likely to have a skeletal survey performed compared with their white counterparts, even after controlling for insurance status, independent expert determination of likelihood of abuse, and appropriateness of performing a skeletal survey (adjusted odds ratio [OR], 8.75; 95% confidence interval [CI], 3.48-22.03; P<.001). This group of children was also more likely to be reported to CPS compared with white toddlers, even after controlling for insurance status and likelihood of abuse (adjusted OR, 4.32; 95% CI, 1.63-11.43; P =.003). By likelihood of abuse, differential ordering of skeletal surveys and reporting of suspected abuse were most pronounced for children at least 12 months old with accidental injuries; however, differences were also noted among toddlers with indeterminate injuries but not among infants or toddlers with abusive injuries. Minority children at least 12 months old with accidental injuries were more than 3 times more likely than their white counterparts to be reported for suspected abuse (for children with Medicaid or no insurance, relative risk [RR], 3.08; 95% CI, 1.37-4.80; for children with private insurance, RR, 3.74; 95% CI, 1.46-6.01). CONCLUSION While minority children had higher rates of abusive fractures in our sample, they were also more likely to be evaluated and reported for suspected abuse, even after controlling for the likelihood of abusive injury. This suggests that racial differences do exist in the evaluation and reporting of pediatric fractures for child abuse, particularly in toddlers with accidental injuries.
The Effects of Derivatives on Firm Risk and Value

Abstract Using a large sample of nonfinancial firms from 47 countries, we examine the effect of derivative use on firm risk and value. We control for endogeneity by matching users and nonusers on the basis of their propensity to use derivatives. We also use a new technique to estimate the effect of omitted variable bias on our inferences. We find strong evidence that the use of financial derivatives reduces both total risk and systematic risk. The effect of derivative use on firm value is positive but more sensitive to endogeneity and omitted variable concerns. However, using derivatives is associated with significantly higher value, abnormal returns, and larger profits during the economic downturn in 2001–2002, suggesting that firms are hedging downside risk.
Validation of consolidation properties of phosphatic clay at very high void ratios

The void ratio-effective stress and void ratio permeability relationships for phosphate slime mine tailings were measured by several methods. The measurements were used in nonlinear finite strain consolidation theory to predict the progress of settlement of a centrifugal prototype. The predicted and measured settlements were in only approximate agreement, with discrepancies attributed primarily to experimental errors in the centrifugal modeling and probable overestimation of permeabilities by the constant rate of deformation tests.
Pullout Performance of Fully and Partially Bonded Retrofit Anchors in Low-Strength Concrete

Although steel reinforcing bars can be used as post-installed anchors to integrate new structural members to the existing structural system in the seismic retrofit of reinforced concrete structures, premature cone-type concrete failure can reduce the bars’ efficiency when they are anchored into low-strength concrete. This study investigates pullout behaviors of fully and partially bonded chemical anchors post-installed in low-strength concrete. The test parameters are the embedment length, the bonded length of the anchors, and the humidity and dust surface conditions of the anchor holes. The pullout behavior is examined through the load-displacement curves, modes of failure, and anchorage strengths of specimens. The results show that the pullout performance of partially bonded, post-installed chemical anchors embedded in low-strength concrete is significantly better than conventional fully bonded post-installed chemical anchors, which suggests that partially bonded anchoring of deformed bars could be useful for anchorages in seismic retrofit applications. A model is proposed for predicting the pullout strength of anchors that fail due to a combination of concrete cone and bond failures. A good correlation is found between the model predictions and test results from this study compared with previously-published experimental findings.
SOAL: Second-Order Online Active Learning

This paper investigates the problem of online active learning for training classification models from sequentially arriving data. This is more challenging than conventional online learning tasks since the learner not only needs to figure out how to effectively update the classifier but also needs to decide when is the best time to query the label of an incoming instance given limited label budget. The existing online active learning approaches are often based on first-order online learning methods which generally fall short in slow convergence rate and sub-optimal exploitation of available information when querying the labeled data. To overcome the limitations, in this paper, we present a new framework of Second-order Online Active Learning (SOAL), which fully exploits both first-order and second-order information to achieve high learning accuracy with low labeling cost. We conduct both theoretical analysis and empirical studies for evaluating the proposed SOAL algorithm extensively. The encouraging results show clear advantages of the proposed algorithm over a family of state-of-the-art online active learning algorithms.
Change in physical activity during a weight management intervention for breast cancer survivors: Association with weight outcomes

This study examined the effects of a group phone‐based weight management intervention on change in physical activity as measured via accelerometer and self‐report in rural breast cancer survivors. The study also evaluated the role of physical activity on clinically meaningful cut points for weight loss (baseline to 6 months) and weight loss maintenance (6 to 18 months).
A Multilevel Approach to Examine Employees’ Loyal Use of ERP Systems in Organizations

Abstract A successful enterprise resource planning (ERP) system ultimately requires loyal use—proactive, extended use and willingness to recommend such uses to others—by employees. Building on interactional psychology literature and situational strength theory, we emphasize the importance of psychological commitment, in addition to behavioral manifestation, in a multilevel model of loyal use. Our empirical test of the model uses data from 485 employees and 166 information system professionals in 47 large Taiwanese organizations. Individual-level analyses suggest that perceived benefits and workload partially mediate the effects of perceived information quality (IQ) and system quality (SQ) on loyal use. Cross-level analyses show that IQ at the organizational level alleviates the negative effect of an employee’s perceived workload on loyal use; organization-level SQ and service-oriented organizational citizenship behaviors (SOCBs) of internal information systems staff reduce the influence of employees’ perceived benefits. Overall, our findings suggest that IQ, SQ, and SOCBs at the organizational level influence employees’ loyal use in ways different from their effects at the individual level, and seem to affect individuals’ cost–benefit analyses. This study contributes to extant literature by considering the SOCBs of the internal information systems group that have been overlooked by most prior research. Our findings offer insights for managers who should find ways to create positive, salient, shared views of IQ, SQ, and SOCBs in the organization to nourish and foster employees’ loyal use of an ERP system, including clearly demonstrating the system’s utilities and devising viable means to reduce the associated workload.
Optimal Bipartite Network Clustering

We consider the problem of bipartite community detection in networks, or more generally the network biclustering problem. We present a fast two-stage procedure based on spectral initialization followed by the application of a pseudo-likelihood classifier twice. Under mild regularity conditions, we establish the weak consistency of the procedure (i.e., the convergence of the misclassification rate to zero) under a general bipartite stochastic block model. We show that the procedure is optimal in the sense that it achieves the optimal convergence rate that is achievable by a biclustering oracle, adaptively over the whole class, up to constants. The optimal rate we obtain sharpens some of the existing results and generalizes others to a wide regime of average degree growth. As a special case, we recover the known exact recovery threshold in the $\log n$ regime of sparsity. To obtain the general consistency result, as part of the provable version of the algorithm, we introduce a sub-block partitioning scheme that is also computationally attractive, allowing for distributed implementation of the algorithm without sacrificing optimality. The provable version of the algorithm is derived from a general blueprint for pseudo-likelihood biclustering algorithms that employ simple EM type updates. We show the effectiveness of this general class by numerical simulations.
Risk factors for small pharyngeal airway dimensions in preorthodontic children: A three-dimensional study.

OBJECTIVE To analyze which parameters, gathered from standard orthodontic diagnostic material, were most relevant for identifying small pharyngeal airway dimensions in preorthodontic children. MATERIALS AND METHODS The sample was composed of 105 cone beam computed tomography scans of healthy preorthodontic children (44 boys, 61 girls; mean age, 10.7 ± 2.4 years). Airway volume and minimal cross-sectional area were three-dimensionally assessed. Cephalometric features and skeletal maturity were assessed on generated two-dimensional cephalograms. Associations were analyzed and adjusted for age, gender, and skeletal maturity by multiple regression analyses. RESULTS Airway volume and minimal cross-sectional area were significantly smaller in prepubertal children (P < .001, P < .05, respectively) and positively associated with age (P < .001, P < .01, respectively). After adjustment of age, skeletal maturity and gender significant associations were found between pharyngeal airway dimensions and craniofacial morphology. Airway volume was positively associated with maxillary and mandibular width (P < .01; P < .001, respectively) and anterior face height (P < .05; P < .05, respectively). Minimal cross-sectional area was positively associated with maxillary and mandibular width (P < .01; P < .001, respectively) and negatively associated with sagittal jaw relationship (AnPg, P < .05). Mandibular width and age were the most relevant factors for airway volume (r2 = 0.36). Mandibular width and sagittal jaw relationship were the most relevant factors for minimal cross-sectional area (r2 = 0.16). CONCLUSION Pharyngeal airway dimensions were significantly associated with age, skeletal maturity, and craniofacial morphology in all three planes. Children with a reduced mandibular width and increased sagittal jaw relationship are particularly at risk of having small pharyngeal airway dimensions.
Dietary and Fluid Regime Adherence in Chronic Kidney Disease Patients

Introduction: Patients with Chronic Kidney Disease (CKD) needs to modify their lifestyle chiefly focusing on diet and fluid intake as the prognosis of these patients largely depends on adherence to the recommended nutritional regime. Non adherence to the suggested diet and fluids regime leads to rapid worsening of the condition. Methods: Cross sectional survey was conducted to determine the level of adherence to the dietary and fluids restriction among CKD patients. Inclusion criteria’s was, age between 18- 65 years, patients with CKD for at least 6 months and received dietary counseling. Consecutive sampling technique was used to select 100 patients. Data was collected with self-reported Dialysis Diet and Fluid non adherence Questionnaire (DDFQ). Results: Majority (73%) of the subjects was males, 64% belongs to 40-60 years age, majority of them were unemployed. Mean Body Mass Index (BMI) was 20.52 kg/m2, the mean duration of the treatment is 2.15 years and mean fluid intake was 2153ml ml/day and inter-dialytic weight gain was 1.48 kg. Regarding adherence, 20% of them had mild deviation and 69% of them had moderate deviation from dietary restrictions and similarly 69 % of the participants had moderate deviation, and 22% of them had mild deviation from fluid restriction guidelines. Low level of adherence to fluid and diet restrictions was noted in illiterate patients which was significant P<0.05. Conclusion: In spite of the dietary counseling, considerable proportions of the patients were non adherent to the diet and fluid restrictions which necessitate regular counseling to patient and family members.
Extremely low effective population sizes, genetic structuring and reduced genetic diversity in a threatened bumblebee species, Bombus sylvarum (Hymenoptera: Apidae)

Habitat fragmentation may severely affect survival of social insect populations as the number of nests per population, not the number of individuals, represents population size, hence they may be particularly prone to loss of genetic diversity. Erosion of genetic diversity may be particularly significant among social Hymenoptera such as bumblebees (Bombus spp.), as this group may be susceptible to diploid male production, a suggested direct cost of inbreeding. Here, for the first time, we assess genetic diversity and population structuring of a threatened bumblebee species (Bombus sylvarum) which exists in highly fragmented habitat (rather than oceanic) islands. Effective population sizes, estimated from identified sisterhoods, were very low (range 21–72) suggesting that isolated populations will be vulnerable to loss of genetic variation through drift. Evidence of significant genetic structuring between populations (θ = 0.084) was found, but evidence of a bottleneck was detected in only one population. Comparison across highly fragmented UK populations and a continental population (where this species is more widespread) revealed significant differences in allelic richness attributable to a high degree of genetic diversity in the continental population. While not directly related to population size, this is perhaps explained by the high degree of isolation between UK populations relative to continental populations. We suggest that populations now existing on isolated habitat islands were probably linked by stepping‐stone populations prior to recent habitat loss.
The ‘warm’ side of coldness: Cold promotes interpersonal warmth in negative contexts

The concrete experience of physical warmth has been demonstrated to promote interpersonal warmth. This well‐documented link, however, tells only half of the story. In the current study, we thus examined whether physical coldness can also increase interpersonal warmth under certain circumstances. We conducted three experiments to demonstrate that the relationship between the experience of physical temperature and interpersonal outcomes is context dependent. Experiment 1 showed that participants touching cold (vs. warm) objects were more willing to forgive a peer's dishonest behaviour. Experiment 2 demonstrated the fully interactive effect of temperature and context on interpersonal warmth: Participants touching cold (vs. warm) objects were less likely to assist an individual who had provided them with good service (positive social context), but more likely to assist an individual who had provided them with poor service (negative social context). Experiment 3 replicated the results of Experiment 2 using the likelihood to complain, a hostility‐related indicator, as the dependent variable: In a pleasant queue (positive social context), participants touching cold objects were more likely to complain and those touching warm objects were less likely to complain compared with the control group. This pattern was reversed in an annoying queue (negative social context).
The Gillette Stadium Experience: A Retrospective Review of Mass Gathering Events From 2010 to 2015

Abstract Objective Mass gathering events can substantially impact public safety. Analyzing patient presentation and transport rates at various mass gathering events can help inform staffing models and improve preparedness. Methods A retrospective review of all patients seeking medical attention across a variety of event types at a single venue with a capacity of 68,756 from January 2010 through September 2015. Results We examined 232 events with a total of 8,260,349 attendees generating 8157 medical contacts. Rates were 10 presentations and 1.6 transports per 10,000 attendees with a non-significant trend towards increased rates in postseason National Football League games. Concerts had significantly higher rates of presentation and transport than all other event types. Presenting concern varied significantly by event type and gender, and transport rate increased predictably with age. For cold weather events, transport rates increased at colder temperatures. Overall, on-site physicians did not impact rates. Conclusions At a single venue hosting a variety of events across a 6-year period, we demonstrated significant variations in presentation and transport rates. Weather, gender, event type, and age all play important roles. Our analysis, while representative only of our specific venue, may be useful in developing response plans and staffing models for similar mass gathering venues. (Disaster Med Public Health Preparedness. 2018;12:752-758).