Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychosocial interventions for substance-abusing parents and their young children: A scoping review

Abstract The aim of this scoping review was to give an overview of efficacy research on psychosocial interventions aimed at substance-abusing parents with children of up to the age of three. Throughout the overview, there was a focus on underlying assumptions and how the problem descriptions motivating the interventions corresponded with the solutions, i.e. the interventions in question. The data consisted of peer reviewed intervention studies (n = 22) identified through literature searches in online databases. Randomised controlled trial studies as well as quasi-experimental and pre-post studies were included. The results showed that all the studies included bar one focused exclusively on women as parents. Moreover, while the problem descriptions in the studies tended to be quite broad, framing parental substance abuse as a problem influenced by social and structural conditions, the solutions presented in the form of interventions generally had a narrower focus, addressing the individual parent from a psychological perspective only. In conclusion, the review points out the need for developing and evaluating interventions aimed at substance-abusing fathers as well as mothers, and also underscores the importance of these interventions being focused on a broader range of factors rather than just addressing deficits at the level of the individual.
Expression of myogenic regulatory factors in rat skeletal muscles after denervation

Aim: The aim of this study was to investigate expression of myogenic regulatory factors MyoD and myogenin during denervation in fast and slow rat skeletal muscles of different rat strains (Wistar and Sprague-Dawely). MaterialandMethods: Immunohistochemical and Western blot analyses were performed on tibialis anterior and soleus muscles. Results: Immunohistochemical analysis of tibialis anterior and soleus muscles during denervation demonstrated that both myonuclei and satellite cells were activated. Western blot analysis showed a significant upregulation of MyoD and myogenin proteins in m. tibialis anterior at all time points of denervation, except on 60 th day for MyoD. In m. soleus during denervation Western blot analysis showed upregulation of MyoD and myogenin in first 14 days, and there was no expression after that period. Conclusion: Our results indicate that MyoD and myogenin protein expression during denervation is muscle type specific. The role of MyoD and myogenin in adult muscle is potentially also important in orchestrating an adaptive response of existing muscle fibers during denervation.
Development of EST-derived microsatellite markers in the aquatic macrophyte Ranunculus bungei (Ranunculaceae)1

Premise of the study: Microsatellite or simple sequence repeat (SSR) markers were developed to investigate the influence of ecological factors on gene flow and spatial genetic structuring of the submerged plant Ranunculus bungei (Ranunculaceae), which is regarded as an important species for understanding how plants adapt to an aquatic environment. Methods and Results: Twenty-two microsatellite loci were identified from an expressed sequence tag (EST) library. The number of alleles per locus ranged from one to five, and the expected heterozygosity varied from 0.0 to 0.5 in four Chinese populations of R. bungei. Fourteen loci were polymorphic and significantly deviated from Hardy–Weinberg equilibrium. All of the loci were found to be amplifiable in two other species of Ranunculus section Batrachium, and cross-amplification in six riparian and aquatic species of Ranunculaceae was also partially successful. Conclusions: These novel EST-SSR markers will be useful for ecological and evolutionary studies of R. bungei as well as related species.
Corporate Governance , Earnings Management and Financial Performance : A Case of Nigerian Manufacturing Firms

Accountants and financial economists have for long identified that corporate governance affects both financial performance and the opportunistic behaviour of managers. Studies on the influence of corporate governance mechanisms on firm performance often overlook the possibility that reported earnings can be misrepresented by managers in order to achieve a variety of objectives. This paper examines the relationship between corporate governance on corporate financial performance when performance is stripped of the discretionery component of accruals. Secondary data were extracted from annual reports of the sample firms for the period between 2008 to 2010 and univariate OLS multiple regression was used as a tool for data analysis. The study documents that corporate governance significantly impact on both the adjusted and unadjusted firm performance in different magnitudes and directions. Specifically, it is emperically established that board composition is inversely related with true performance while a positive interraction emerges between executive compensation and firm performance regardless of the performance specification.
TRANSLAMINAR VERSUS PEDICLE SCREW FIXATION OF C2: COMPARISON OF SURGICAL MORBIDITY AND ACCURACY OF 313 CONSECUTIVE SCREWS

OBJECTIVE C2 translaminar (TL) screws rigidly capture the posterior elements of C2, avoid risk of vertebral artery injury, and are less technically demanding than C2 pedicle (PD) screws. However, a C2-TL screw breach places the spinal cord at risk, and the durability of C2-TL screws remains unknown. It is unclear if TL versus PD screw fixation of C2 is truly associated with less operative morbidity, greater accuracy of screw placement, or equivalent durability. METHODS We retrospectively reviewed the records of 167 consecutive patients undergoing posterior cervical fusion with either PD or TL screw fixation of C2. Perioperative morbidity, breach of the C2 lamina or pedicle on postoperative computed tomographic scans, and rates of operative revision were compared between PD and TL screw constructs in axial (C1–C2 or C1–C3) and subaxial (C2 and caudal) cervical fusions. RESULTS In total, 152 C2-TL screws and 161 C2-PD screws were placed in 167 patients. Thirty-one (19%) cases of axial cervical fusion (C1–C2 or C1–C3) were performed (mean age, 63.8 ± 20.6 years) with either C2-TL (16 [52%]) or C2-PD (15 [48%]) screw fixation. One hundred thirty-six (81%) cases of subaxial cervical fusion (C2-caudal) were performed (mean age, 57.9 ± 14.7 years) with either C2-TL (66 [49%]) or C2-PD (70 [51%]) screw fixation. For both axial and subaxial cervical fusions, baseline patient characteristics and all measures of perioperative morbidity were similar between C2-TL and C2-PD screw cohorts. In total, 11 (7%) PD screws breached the pedicle (0 requiring acute revision) versus only 2 (1.3%) TL screws that breached the C2 lamina (1 requiring acute revision) (P = 0.018). By 1 year postoperatively, pseudoarthrosis or screw pullout requiring reoperation was required in 4 (6.1%) patients with C2-TL screws versus 0 (0%) patients with PD screws (P < 0.05 for subaxial constructs). No cases of C2-TL or C2-PD axial fusion required reoperation or screw pullout or pseudoarthrosis. CONCLUSION In our experience, radiographic breach of C2 pedicle screws occurred more frequently than C2 laminar screw breach. However, this was not associated with an increase in morbidity. By 12 months postoperatively, C2-TL screws were associated with a greater incidence of operative revision when used in subaxial constructs but similarly effective for axial cervical constructs. The 1-year durability of C2-TL screws might be inferior to C2 pedicle screws for subaxial fusions, but equally effective for axial cervical fusions.
Transformational Leadership and Inter-Team Collaboration

We develop and test a model of the effects of transformational leadership beyond the boundaries of a team to the level of collaboration with other teams. We also test team size as a boundary condition in this relationship. In a study using a crisscross design to control common method bias, using a sample of 388 teams from a leading, global electronics company, the results from structural equation modeling (SEM) reveal that teams with transformational leaders are more likely to have higher internal teamwork quality (TWQ) and receive high inter-team collaboration ratings from other teams. Results further support the expectation that the association between transformational leadership and inter-team collaboration is mediated by TWQ and moderated by team size. The importance of transformational leadership for team-level research, as well as its hidden benefits beyond internal team boundaries, is discussed.
Competitive Group Testing and Learning Hidden Vertex Covers with Minimum Adaptivity

Suppose that we are given a set of n elements d of which are "defective". A group test can check for any subset, called a pool, whether it contains a defective. It is well known that d defectives can be found by using O(d log n) pools. This nearly optimal number of pools can be achieved in 2 stages, where tests within a stage are done in parallel. But then d must be known in advance. Here we explore group testing strategies that use a nearly optimal number of pools and a few stages although d is not known to the searcher. One easily sees that O(log d) stages are sufficient for a strategy with O(d log n) pools. Here we prove a lower bound of Ω(log d/ log log d) stages and a more general pools vs. stages tradeoff. As opposed to this, we devise a randomized strategy that finds d defectives using O(d log(n/d)) pools in 3 stages, with any desired probability 1 - Ɛ. Open questions concern the optimal constant factors and practical implications. A related problem motivated by, e.g., biological network analysis is to learn hidden vertex covers of a small size k in unknown graphs by edge group tests. (Does a given subset of vertices contain an edge? )We give a 1-stage strategy using O(k3 log n) pools, with any FPT algorithm for vertex cover enumeration as a decoder.
Individual-group discontinuity from the differing perspectives of Campbell's Realistic Group Conflict Theory and Tajfel and Turner's Social Identity Theory.

Two experiments investigated the implications of realistic group conflict theory and social identity theory for explaining the individual-group discontinuity effect. We interpreted realistic group conflict theory as directly implying that individual-group discontinuity is motivated by competition for valued outcomes (max own); we interpreted social identity theory as suggesting that individual-group discontinuity is motivated by relativistic social comparisons (max rel). We developed a new three-choice matrix to differentiate max own from max rel competitiveness
The Influence of Neighbourhoods and the Social Environment on Sedentary Behaviour in Older Adults in Three Prospective Cohorts

Sedentary behaviour is an emerging risk factor for poor health. This study aimed to identify ecological determinants of sedentary behaviour, for which evidence is currently scarce. The study participants were community dwelling adults from, respectively, the Lothian Birth Cohort 1936 (n = 271, mean age 79) and the 1930s (n = 119, mean age 83) and 1950s (n = 310, mean age 64) cohorts of the West of Scotland Twenty-07 study. The outcome measure, percentage of waking time spent sedentary (sedentary time), was measured using an activPAL activity monitor worn continuously for seven days. Potential determinants included objective and subjective neighbourhood measures such as natural space, crime, social cohesion and fear of crime. Other determinants included measures of social participation such as social support, social group membership and providing care. Results from multivariable regression analyses indicated that providing care was associated with reduced sedentary time in retired participants in all cohorts. Fear of crime and perceived absence of services were associated with increased sedentary time for retired 1950s cohort members. Higher crime rates were associated with increased sedentary time in all cohorts but this was not significant after adjustment for socio-demographic characteristics. Most other neighbourhood and social participation measures showed no association with sedentary time.
The genetics of a putative social trait in natural populations of yeast

The sharing of secreted invertase by yeast cells is a well‐established laboratory model for cooperation, but the only evidence that such cooperation occurs in nature is that the SUC loci, which encode invertase, vary in number and functionality. Genotypes that do not produce invertase can act as ‘cheats’ in laboratory experiments, growing on the glucose that is released when invertase producers, or ‘cooperators’, digest sucrose. However, genetic variation for invertase production might instead be explained by adaptation of different populations to different local availabilities of sucrose, the substrate for invertase. Here we find that 110 wild yeast strains isolated from natural habitats, and all contained a single SUC locus and produced invertase; none were ‘cheats’. The only genetic variants we found were three strains isolated instead from sucrose‐rich nectar, which produced higher levels of invertase from three additional SUC loci at their subtelomeres. We argue that the pattern of SUC gene variation is better explained by local adaptation than by social conflict.
Gallbladder Epithelium as a Niche for Chronic Salmonella Carriage

ABSTRACT Although typhoid fever has been intensively studied, chronic typhoid carriage still represents a problem for the transmission and persistence of the disease in areas of endemicity. This chronic state is highly associated with the presence of gallstones in the gallbladder of infected carriers upon which Salmonella can form robust biofilms. However, we hypothesize that in addition to gallstones, the gallbladder epithelium aids in the establishment/maintenance of chronic carriage. In this work, we present evidence of the role of the gallbladder epithelium in chronic carriage by a mechanism involving invasion, intracellular persistence, and biofilm formation. Salmonella was able to adhere to and invade polarized gallbladder epithelial cells apically in the absence and presence of bile in a Salmonella pathogenicity island 1 (SPI-1)-dependent manner. Intracellular replication of Salmonella was also evident at 12 and 24 h postinvasion. A flowthrough system revealed that Salmonella is able to adhere to and form extensive bacterial foci on gallbladder epithelial cells as early as 12 h postinoculation. In vivo experiments using a chronic mouse model of typhoid carriage showed invasion and damage of the gallbladder epithelium and lamina propria up to 2 months after Salmonella infection, with an abundant presence of macrophages, a relative absence of neutrophils, and extrusion of infected epithelial cells. Additionally, microcolonies of Salmonella cells were evident on the surface of the mouse gallbladder epithelia up to 21 days postinfection. These data reveal a second potential mechanism, intracellular persistence and/or bacterial aggregation in/on the gallbladder epithelium with luminal cell extrusion, for Salmonella maintenance in the gallbladder.
A Quantitative Study of the Internationalization of the Academics and Research Productivity: Case Study of China

Abstract: With the significant rise in China’s economic strength, more students and scholars have returned to China recently. But there is limited literature examining academics with foreign degrees and their research productivity. Using the data of the Changing Academic Profession in Asia (APA) survey, which was exercised in 2012, this study expands the understanding of personal characteristics of academics with foreign degrees in Chinese universities and examines their research productivity in comparison to that of those with domestic degrees. Results show that academics with foreign degrees are more productive in coauthored foreign articles and receive more research funding, leading to higher research productivity, than do those with domestic degrees. The author also finds that some international factors might have increased academics’ productivity, especially, in publishing articles in a foreign language. Implications are presented about how to provide more research funding and more opportunities for academics at an international dimension to enhance their research productivity.
How to Get Better Care with Lower Costs? See the Person, Not the Patient

The U.S. health system perceives people as “patients” almost exclusively as they enter and exit the healthcare system, but with this emphasis on context, have we lost sight of the people who should be in the foreground of care? Does such a view impede care effectiveness and efficiency? How can we shift our frame of reference moving forward? To foster this needed conceptual shift, a group of national thought‐leaders convened by the American Geriatrics Society (AGS) defined “person‐centered care” to reorient the perspective toward individuals remaining in the center of pursuing high‐quality care. This article explores how a person‐centered care approach can improve healthcare effectiveness and efficiency, particularly for older adults with heightened health and daily living needs, and healthcare costs. The process for supporting a person‐centered program is outlined, three critical indicators that define person‐centered quality are highlighted, and several models that embrace the person‐centered paradigm are briefly noted. Although there is no one‐size‐fits‐all schematic, how and why overall success entails fidelity to essential elements of person‐centered programs as the AGS expert panel identified is explained.
‘Transit’ and ‘Suspension’: Migration Management or the Metamorphosis of Asylum-Seekers into ‘Illegal’ Immigrants

This article explores the historical construction of the ‘transit country’ as one answer to the perceived loss of control over migration that governments of the developed North have increasingly felt. A frenzy of re-conceptualisations has taken place over the past 20 years, leading to a discourse—unquestioned and accepted by policy-makers and many academics—of Migration Management. A consequence of the evolution of Migration Management is captured by the notion of ‘suspension’, which often refers to either the physical or the metaphorical death of a certain minority of illegal migrants. However, I argue that such ‘suspended’ illegal migrants have the capacity to reinvent themselves precisely because they are outside the realm of juridico-political categorisation and enumeration.
Spatial structures of stream and hillslope drainage networks following gully erosion after wildfire

The drainage networks of catchment areas burned by wildfire were analysed at several scales. The smallest scale (1–1000 m2) representative of hillslopes, and the small scale (1000 m2 to 1 km2), representative of small catchments, were characterized by the analysis of field measurements. The large scale (1–1000 km2), representative of perennial stream networks, was derived from a 30‐m digital elevation model and analysed by computer analysis.
FEASIBLE MODEL PREDICTIVE CONTROL WITH BOUNDED DISTURBANCES

This paper shows how to calculate feasible regions, parameterized in terms for the present state xk, for MPC controllers for constrained linear systems. The dependence of the feasible region on the prediction horizon is also made clear. It is also shown how the procedure may be modified to find guaranteed feasible regions in the presence of unknown, bounded disturbances. These ‘robust’ feasible regions are used to propose a very simple MPC controller which achieves robust feasibility.
Microenvironment Promotes Tumor Cell Reprogramming in Human Breast Cancer Cell Lines

The microenvironment drives mammary gland development and function, and may influence significantly both malignant behavior and cell growth of mammary cancer cells. By restoring context, and forcing cells to properly interpret native signals from the microenvironment, the cancer cell aberrant behavior can be quelled, and organization re-established. In order to restore functional and morphological differentiation, human mammary MCF-7 and MDA-MB-231 cancer cells were allowed to grow in a culture medium filled with a 10% of the albumen (EW, Egg White) from unfertilized chicken egg. That unique microenvironment behaves akin a 3D culture and induces MCF-7 cells to produce acini and branching duct-like structures, distinctive of mammary gland differentiation. EW-treated MDA-MB-231 cells developed buds of acini and duct-like structures. Both MCF-7 and MDA-MB-231 cells produced β-casein, a key milk component. Furthermore, E-cadherin expression was reactivated in MDA-MB-231 cells, as a consequence of the increased cdh1 expression; meanwhile β-catenin – a key cytoskeleton component – was displaced behind the inner cell membrane. Such modification hinders the epithelial-mesenchymal transition in MDA-MB-231 cells. This differentiating pathway is supported by the contemporary down-regulation of canonical pluripotency markers (Klf4, Nanog). Given that egg-conditioned medium behaves as a 3D-medium, it is likely that cancer phenotype reversion could be ascribed to the changed interactions between cells and their microenvironment.
Parental social responsiveness and risk of autism spectrum disorder in offspring.

IMPORTANCE Although autism spectrum disorder (ASD) is known to be heritable, patterns of inheritance of subclinical autistic traits in nonclinical samples are poorly understood. OBJECTIVE To examine the familiality of Social Responsiveness Scale (SRS) scores of individuals with and without ASD. DESIGN, SETTING, AND PARTICIPANTS We performed a nested case-control study (pilot study: July 1, 2007, through June 30, 2009; full-scale study: September 15, 2008, through September 14, 2012) within a population-based longitudinal cohort. Participants were drawn from the Nurses' Health Study II, a cohort of 116,430 female nurses recruited in 1989. Case participants were index children with reported ASD; control participants were frequency matched by year of birth of case participants among those not reporting ASD. Of 3161 eligible participants, 2144 nurses (67.8%) returned SRS forms for a child and at least 1 parent and were included in these analyses. EXPOSURE The SRS scores, as reported by nurse mothers and their spouses, were examined in association with risk of ASD using crude and adjusted logistic regression analyses. The SRS scores of the children were examined in association with SRS scores of the parents using crude and adjusted linear regression analyses stratified by case status. MAIN OUTCOMES AND MEASURES Autism spectrum disorder, assessed by maternal report, validated in a subgroup with the Autism Diagnostic Interview-Revised. RESULTS A total of 1649 individuals were included in these analyses, including 256 ASD case participants, 1393 control participants, 1233 mothers, and 1614 fathers. Risk of ASD was increased by 85.0% among children whose parents had concordantly elevated SRS scores (odds ratio [OR], 1.85; 95% CI, 1.08-3.16) and by 52.0% when the score of either parent was elevated (OR, 1.52; 95% CI, 1.11-2.06). Elevated scores of the father significantly increased the risk of ASD in the child (OR, 1.94; 95% CI, 1.38-2.71), but no association was seen with elevated scores of the mother. Elevated parent scores significantly increased child scores in controls, corresponding to an increase in 23 points (P < .001). CONCLUSIONS AND RELEVANCE These findings support the role of additive genetic influences in concentrating inherited ASD susceptibility in successive generations and the potential role of preferential mating, and suggest that typical variation in parental social functioning can produce clinically significant differences in offspring social traits.