Miracle-dz/UniFAR-FTUs huggingface dataset:
Virtual Reality Job Interview Training and 6-Month Employment Outcomes for Individuals with Substance Use Disorders Seeking Employment.

BACKGROUND Individuals with substance use disorders (SUDs) have low employment rates and job interviewing is a critical barrier to employment for them. Virtual reality training is efficacious at improving interview skills and vocational outcomes for several clinical populations. OBJECTIVE This study evaluated the acceptability and efficacy of virtual reality job interview training (VR-JIT) at improving interview skills and vocational outcomes among individuals with SUDs via a small randomized controlled trial (n=14 VR-JIT trainees, n=11 treatment-as-usual (TAU) controls). METHODS Trainees completed up to 10 hours of virtual interviews, while controls received services as usual. Primary outcome measures included two pre-test and two post-test video-recorded role-play interviews and vocational outcomes at six-month follow-up. RESULTS Trainees reported that the intervention was easy-to-use and helped prepared them for future interviews. While co-varying for pre-test role-play performance, trainees had higher post-test role-play scores than controls at the trend level (p<0.10). At 6-month follow-up, trainees were more likely than controls to attain a competitive position (78.6% vs. 44.4%, p<0.05, respectively). Trainees had greater odds of attaining a competitive position by 6 month follow-up compared to controls (OR: 5.67, p<0.05). VR-JIT participation was associated with fewer weeks searching for a position (r= -0.36, p<0.05). CONCLUSIONS There is preliminary evidence that VR-JIT is acceptable to trainees. Moreover, VR-JIT led to better vocational outcomes with trainees having greater odds of attaining a competitive position by 6-month follow-up. Future studies could evaluate the effectiveness of VR-JIT within community-based services.
PUFs at a glance

Physical Unclonable Functions (PUFs) are a new, hardware-based security primitive, which has been introduced just about a decade ago. In this paper, we provide a brief and easily accessible overview of the area. We describe the typical security features, implementations, attacks, protocols uses, and applications of PUFs. Special focus is placed on the two most prominent PUF types, so-called “Weak PUFs” and “Strong PUFs”, and their mutual differences.
Therapeutic implications of contractile reserve elicited by dobutamine echocardiography in symptomatic, low-gradient aortic stenosis.

BACKGROUND In patients with heart failure, poor ejection fraction and estimated severe aortic stenosis because of a reduced aortic valve area (AVA) and low gradients, dobutamine echocardiography (DE) was proposed to distinguish afterload mismatch from primary left ventricular dysfunction. In this setting the feasibility and safety of DE and the outcome following management based on DE results were investigated. METHODS Forty-eight patients (mean age 73 +/- 9 years; 79% males; AVA 0.7 +/- 0.2 cm2; mean aortic gradient 22 +/- 6 mmHg; ejection fraction 0.28 +/- 0.07; NYHA functional class 2.9 +/- 0.8) underwent DE and were followed up for 24 +/- 21 months. Aortic valve replacement (AVR) was offered to patients with left ventricular contractile reserve (ejection fraction increase > or = 30% at peak DE) and fixed aortic stenosis (AVA increase < or = 0.25 cm2). RESULTS DE elicited a left ventricular contractile reserve in 38 patients (79%). Among these, fixed aortic stenosis was present in 28 patients, among whom 19 underwent AVR and 9 declined surgery. The 20 patients without contractile reserve or with relative stenosis (AVA increase > 0.25 cm2) were not considered eligible for surgery. During follow-up, 23 cardiovascular deaths occurred: 2/19 among operated patients, 7/9 among patients who declined surgery and 14/20 among non-eligible patients. Patients with AVR showed a significantly more favorable outcome and improved functional status as compared to the other two groups (NYHA class 1.2 +/- 0.4 vs 2.7 +/- 0.6 at baseline; p < 0.001). Conversely, non-surgical management was the strongest independent predictor of an adverse outcome (relative risk 3.6, 95% confidence interval 1.8-7.3; p < 0.0001). CONCLUSIONS In patients with heart failure and estimated severe aortic stenosis, DE could identify a subgroup with a left ventricular contractile reserve and fixed aortic stenosis who gained great benefit from AVR. The clinical outcome of patients who were not operated upon was unfavorable.
Representations of the Police in Contemporary Russian Police TV Series

This article answers the question of how contemporary Russian TV series portray the police. The results derive from a single-case thematic and functionalist study of the popular Russian TV series Glukhar’ (which aired from 2008 to 2011). The show merits special attention because it was on air when the Russian police were undergoing a legitimacy crisis, which lead to the 2009 police reform. The series recognized the crisis and responded to it with a set of justifications. I analyze the show’s social and cultural contexts, its plot patterns, and the functions of its characters. I build a typology of justifications and claim that the show justifies the police through an open discussion about the reasons for and consequences of their lawlessness. The series shows that the legitimacy of the police is repeatedly questioned, but trust in the police is always restored because police officers are depicted as estranged from the state but not from the community. Thus, the show contains an interesting example of overcoming a legitimacy crisis through its recognition. The study opens the floor to further discussions about how popular culture resolves intense social debates about policing by symbolic means in a moment when police legitimacy is contested.
PYRAMIDAL CELLS: ROLE IN PRIMATE PREFRONTAL CORTEX CIRCUITRY DURING POSTNATAL DEVELOPMENT AND SCHIZOPHRENIA

Cognitive deficits constitute a core feature of schizophrenia, are persistent across the course of the illness and are the best predictor of long-term functional outcome. Dysfunction in certain cognitive processes, such as working memory, are common in subjects with schizophrenia and have been attributed to aberrant function of the dorsolateral prefrontal cortex (DLPFC). This dysfunction appears to reflect, at least in part, alterations in excitatory neurotransmission. Cortical pyramidal neurons, the principal source of cortical glutamate neurotransmission, exhibit highly robust molecular and morphological alterations in schizophrenia. These alterations appear to be most pronounced in DLPFC deep layer 3, the same microcircuit necessary for the generation of neural oscillations in the γ-frequency range that sustain working memory function. Understanding how dysfunction in DLPFC cortical circuits in deep layer 3 might give rise to the pathophysiology of altered γ-frequency oscillations and working memory deficits in schizophrenia require an interrogation of the mechanisms by which these neuropathological alterations may arise, but also the normal developmental trajectories of these vulnerable microcircuits. In this dissertation, we provide evidence for pyramidal cell type-specific molecular disturbances and synapse-specific structural impairments in DLPFC deep layer 3, and cell type-specific and layer-specific nature of postnatal developmental refinements in pyramidal cells in the DLPFC, within the circuitry that subserves γ-frequency oscillations and working memory. Accordingly, we have identified alterations in the expression of numerous molecular regulators of the actin cytoskeleton in a layer-specific and cell type-specific manner in DLPFC deep layer 3 in individuals with schizophrenia that might be a critical “upstream” cause in the pathogenesis of the illness. Additionally, using novel triple-label fluorescence immunohistochemistry and spinning-disk confocal microscopy, we characterize specific synaptic connections onto DLPFC deep layer 3 pyramidal cells in schizophrenia. Finally, we demonstrate that the developmental trajectories of primate DLPFC deep layer 3 pyramidal neurons are protracted, and layer-specific and posit that the molecular maturation of GABA synapses on pyramidal cells may account, at least in part, for the maturation of synchronized pyramidal cell firing which is crucial for γ-frequency oscillations.
Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord.

We previously reported that the intraplantar (i.pl.) application of nociceptin/orphanin FQ (N/OFQ) at extremely low doses elicited a nociception through a substance P (SP) release from nociceptor endings. In the present study, the nociception induced by SP (and N/OFQ) was abolished by intrathecal (i.t.) injection of neurokinin(1) (SP receptor) antagonist, suggesting the involvement of the stimulation of nociceptive primary SP neuron and SP release into spinal synapses. On the other hand, similar low doses of N/OFQ (i.t.) exerted nociceptive responses, characterized by scratching, biting, and licking, and these responses were blocked by an neurokinin(1) antagonist (i.t.) or capsaicin pretreatment or in tachykinin 1 gene knockout mice (tac1(-/-) mice), suggesting that N/OFQ receptor (NOR) also exists on the spinal terminals of SP neurons. When wide ranges of N/OFQ doses were used, a typical bell-shaped dose-response relationship was observed in both peripheral and central nociception tests. Furthermore, N/OFQ (1 nmol) administered i.pl. blocked SP (i.pl.)-induced flexor responses, which were abolished by pertussis toxin pretreatment or in NOR gene knockout (NOR(-/-)) mice. On the other hand, N/OFQ administered i.t. blocked SP (i.t.)-induced scratching, biting, and licking in capsaicin-pretreated and tac1(-/-) mice, and this antinociception was abolished in NOR(-/-) mice. All these findings suggest that N/OFQ has biphasic actions depending on doses in the nociceptors and spinal synapses and has postsynaptic antinociceptive actions in spinal cord by modulating SP signaling.
Authoring the self: Media, voice and testimony in soldiers’ memoirs

In this article, the author focuses on the struggles over self-representation that soldiers have engaged in at two key historical moments of modern Western warfare: the First World War, the first major industrialised conflict of the 20th century (1914–1918); and the Iraq and Afghanistan Wars, the so-called ‘War on Terror’, which marked the emergence of information warfare in the 21st century (2001–2014). The Western soldier’s self-representation, the author concludes, has shifted from a practice of observing the battlefield as a strange place and himself as an ‘other’ within it, to a practice of considering the ‘other’, here the Iraqi or Afghani local, as the self, someone who shares a Western sense of humanity. These antithetical self-representations, the author argues, point in turn to complex transformations in the technologies, moralities and cultures of warfare, throwing into relief uneasy tensions in the West’s 21st-century interventionist conflicts. In their attempt to move away from the massacres of the 20th-century wars, such conflicts are suspended between sharing humanity and misrecognising ‘others’, between liberating and conquering, between saving and taking lives.
Preventive effect of neutropenia on carbon tetrachloride‐induced hepatotoxicity in rats

The preventive effect of neutropenia on carbon tetrachloride (CCl4)‐induced hepatotoxicity was examined in rats. In rats treated once with CCl4 (1 ml kg−1, i.p.), the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), indices of liver cell damage, and the hepatic activity of myeloperoxidase (MPO), an index of tissue neutrophil infiltration, increased at 6 h after the intoxication and further increased at 24 h. The liver of CCl4‐treated rats showed an increase in the concentration of thiobarbituric acid reactive substances (TBARS), an index of lipid peroxidation, and decreases in superoxide dismutase (SOD) activity and reduced glutathione (GSH) concentration at 6 h after the intoxication followed by a further increase in TBARS concentration and further decreases in SOD activity and GSH concentration at 24 h with increased xanthine oxidase (XO) activity at 24 h. Neutropenic treatment with anti‐rat neutrophil antiserum (2 ml kg−1, i.p.) at 0.5 h after CCl4 intoxication attenuated the increases in serum ALT and AST activities and hepatic MPO activity and TBARS concentration and the decreases in hepatic SOD activity and GSH concentration found at 6 and 24 h after CCl4 intoxication and the increase in hepatic XO activity found at 24 h after the intoxication. This neutropenia reduced the necrotic and degenerative changes with inflammatory cell infiltration in the liver cell of CCl4‐treated rats. These results indicate that neutropenia prevents CCl4‐induced hepatotoxicity in rats by attenuating the disruption of hepatic reactive oxygen species metabolism mediated by neutrophils accumulating in the liver tissue. Copyright © 2005 John Wiley & Sons, Ltd.
Representations of modality‐specific affective processing for visual and auditory stimuli derived from functional magnetic resonance imaging data

There is converging evidence that people rapidly and automatically encode affective dimensions of objects, events, and environments that they encounter in the normal course of their daily routines. An important research question is whether affective representations differ with sensory modality. This research examined the nature of the dependency of affect and sensory modality at a whole‐brain level of analysis in an incidental affective processing paradigm. Participants were presented with picture and sound stimuli that differed in positive or negative valence in an event‐related functional magnetic resonance imaging experiment. Global statistical tests, applied at a level of the individual, demonstrated significant sensitivity to valence within modality, but not valence across modalities. Modality‐general and modality‐specific valence hypotheses predict distinctly different multidimensional patterns of the stimulus conditions. Examination of lower dimensional representation of the data demonstrated separable dimensions for valence processing within each modality. These results provide support for modality‐specific valence processing in an incidental affective processing paradigm at a whole‐brain level of analysis. Future research should further investigate how stimulus‐specific emotional decoding may be mediated by the physical properties of the stimuli. Hum Brain Mapp 35:3558–3568, 2014. © 2013 Wiley Periodicals, Inc.
Risk factors for serious suicide attempts among youths aged 13 through 24 years.

OBJECTIVE To examine associations between a series of sociodemographic factors, childhood experiences, and mental disorders and risk of serious suicide attempt in young people aged 13 through 24 years and to explore the joint relationship between these factors and vulnerability to serious suicide attempt. METHOD The study used a case-control design in which a sample of 129 young people who had made serious suicide attempts was contrasted with 153 randomly selected community controls. Measures included sociodemographic factors (educational qualifications, annual income, residential mobility), childhood experiences (parental relationship, parental care, childhood sexual abuse), and psychiatric morbidity. RESULTS On the basis of multiple logistic regression, those making serious suicide attempts reported elevated rates of sociodemographic disadvantage (p < .0001), higher rates of disadvantageous childhood experiences (p < .05), and elevated rates of psychiatric morbidity (p < .0001). CONCLUSIONS Risks of serious suicide attempt among young people increased with extent of exposure to childhood adversity, social disadvantage, and psychiatric morbidity, with each of these factors making independent contributions to risk of serious suicide attempt.
Systematic implicit solvent coarse-graining of bilayer membranes: lipid and phase transferability of the force field

We study the lipid and phase transferability of our recently developed systematically coarse-grained solvent-free membrane model. The force field was explicitly parameterized to describe a fluid 1-palmitoyl-2-oleoyl-phosphatidylcholine (POPC) bilayer at 310 K with correct structure and area per lipid, while gaining at least three orders of magnitude in computational efficiency (see Wang and Deserno 2010 J. Phys. Chem. B 114 11207–20). Here, we show that exchanging CG tails, without any subsequent re-parameterization, creates reliable models of 1,2-dioleoylphosphatidylcholine (DOPC) and 1,2-dipalmitoylphosphatidylcholine (DPPC) lipids in terms of structure and area per lipid. Furthermore, all CG lipids undergo a liquid–gel transition upon cooling, with characteristics like those observed in experiments and all-atom simulations during phase transformation. These studies suggest a promising transferability of our force field parameters to different lipid species and thermodynamic state points, properties that are a prerequisite for even more complex systems, such as mixtures.
Solar cycle variations in polar cap area measured by the superDARN radars

We present a long‐term study, from January 1996 to August 2012, of the latitude of the Heppner‐Maynard Boundary (HMB) measured at midnight using the northern hemisphere Super Dual Auroral Radar Network (SuperDARN). The HMB represents the equatorward extent of ionospheric convection and is used in this study as a measure of the global magnetospheric dynamics. We find that the yearly distribution of HMB latitudes is single peaked at 64° magnetic latitude for the majority of the 17 year interval. During 2003, the envelope of the distribution shifts to lower latitudes and a second peak in the distribution is observed at 61°. The solar wind‐magnetosphere coupling function derived by Milan et al. (2012) suggests that the solar wind driving during this year was significantly higher than during the rest of the 17 year interval. In contrast, during the period 2008–2011, HMB distribution shifts to higher latitudes, and a second peak in the distribution is again observed, this time at 68° magnetic latitude. This time interval corresponds to a period of extremely low solar wind driving during the recent extreme solar minimum. This is the first long‐term study of the polar cap area and the results demonstrate that there is a close relationship between the solar activity cycle and the area of the polar cap on a large‐scale, statistical basis.
Energy expenditure and substrate metabolism measured by 24 h whole-body calorimetry in patients receiving cyclic and continuous total parenteral nutrition.

1. Twenty-four hour energy expenditure and its components, i.e. 'basal metabolic rate', activity energy expenditure and diet-induced thermogenesis were measured, using continuous whole-body indirect calorimetry, in patients receiving total parenteral nutrition while in remission from Crohn's disease (weight 51.9 +/- 9.9 kg, body mass index 19.2 +/- 2.0 kg/m2). 2. Total parenteral nutrition was infused continuously over 24 h in four subjects and cyclically, between 22.00 and 10.00 hours, in eight subjects. Twenty-four hour energy expenditure (6.83 +/- 1.10 MJ/24 h) was lower than total energy intake (10.09 +/- 1.63 MJ/24 h), resulting in a positive energy balance (3.26 +/- 1.42 MJ) in all subjects. Repeated measurements of resting energy expenditure in the continuously fed subjects (5.82 +/- 1.11 MJ/24 h) did not change significantly at different times of day (coefficient of variation 2.2-6.6%). In contrast, in cyclically fed subjects, resting energy expenditure was 24.2 +/- 9.0% higher towards the end of the 12 h feeding period than the 'basal metabolic rate', which was measured just before the start of the feeding period. 3. Diet-induced thermogenesis, calculated as the increment in resting energy expenditure above 'basal metabolic rate' over the 24 h period (adjusted for the reduction in energy expenditure during sleep), was found to be 0.60 +/- 0.29 MJ or 6.1 +/- 3.1% of the energy intake. 4. The energy cost of activity (activity energy expenditure) in the continuously fed patients, calculated as the difference between 24 h energy expenditure and the integrated 24 h measurements of resting energy expenditure, was 0.88 +/- 0.53 MJ, i.e. 12.9 +/- 5.9% of the 24 h energy expenditure. 5. The non-protein non-glycerol respiratory quotient exceeded 1.0 for varying periods of time (0.5-17 h) in 11 subjects, indicating net lipogenesis from carbohydrate. 6. The results demonstrate favourable rates of deposition, during intravenous feeding, of both energy and nitrogen over a 24 h period in patients recovering from an episode of Crohn's disease. The efficacy of these commonly used total parenteral nutrition regimens in these patients is related to three features that are absent in normal healthy individuals, namely a low basal metabolic rate, a low activity-related energy expenditure and prolonged periods of lipogenesis from carbohydrate.
Formation and evolution of galactic disks with a multiphase numerical model

The formation and evolution of galactic disks are complex phenomena, where gas and star dynamics are coupled through star formation and the related feedback. The physical processes are so numerous and intricate that numerical models focus, in general, on one or a few of them only. We propose here a numerical model with particular attention to the multiphase nature of the interstellar medium; we consider a warm gas phase (10 4 K), treated as a continuous fluid by an SPH algorithm, and a cold gas phase (down to 10 K), fragmented in clouds, treated by a low-dissipation sticky particle component. The two gas phases do not have the same dynamics, nor the same spatial distribution. In addition to gravity, they are coupled through mass exchanges due to heating/cooling processes, and supernovae feedback. Stars form out of the cold phase, and re-inject mass to the warm phase through SN explosions and stellar winds. The baryons are embedded in a live cold dark matter component. Baryonic disks, initially composed of pure gas, encounter violent instabilities, and a rapid phase of star formation that slows down exponentially. Stars form in big clumps that accumulate in the center to build a bulge. Exponential metallicity gradients are obtained. External infall of gas should be included to maintain a star formation rate in the disk comparable to what is observed in present disk galaxies.
First-principles study of layered antiferromagnetic CuCrX2 (X = S, Se and Te)

We present detailed electronic band-structure calculations for antiferromagnetic chromium compounds, CuCrX2 (X = S, Se or Te), carried out using spin-polarized density functional theory within the generalized-gradient approximation (GGA). A narrow-band semiconductor-to-metal transition is observed upon replacement of S or Se by Te. The indirect bandgap is found at 0.58 eV and 0.157 eV for CuCrS2 and CuCrSe2, respectively. The results for our theoretical calculations are well in line with the electronic transport properties experimentally observed for CuCrS2 and CuCrSe2.