Miracle-dz/UniFAR-FTUs huggingface dataset:
The relative change in regulatory T cells / T helper lymphocytes ratio as parameter for prediction of therapy efficacy in metastatic colorectal cancer patients

Purpose The evaluation of regulatory T (Treg) (CD4+CD25high CD127neg) lymphocyte count with respect to the T helper (TH) (CD4) number has been shown to represent the main immune parameters capable of signifying the functional status of the anticancer immunity in cancer patients. This study is aimed to explore a correlation between therapy efficacy and changes in Treg/TH ratio and other biochemical and haematological parameters in patients with metastatic colorectal cancer (mCRC). Experimental Design Measurements of regulatory T cells were performed by flow cytometric analysis pre- and post-therapies in a prospective study. Results We investigated levels of Treg/TH ratio in the peripheral blood of 25 mCRC patients pre- and post-chemotherapy ± targeted therapy. There were significant differences in levels of Treg/TH ratio pre- and post-treatments among patients on study, patients with partial response (PR), stable disease (SD) and progressive disease (PD) (P= 0.012, P= 0.011, and P= 0.043, respectively). Moreover, the relative change in Treg/TH ratio showed statistically significant difference among patients with PD as compared to those with PR and SD. Our findings demonstrated a statistically significant strong correlation between the relative change in Treg/TH ratio and therapeutic response. (Spearman's rho= 0.788/p<0.001). Conclusions The monitoring of the relative change in Treg/TH ratio could constitute a promising clinical index for response prediction and a timely change in regimen. Further prospective evaluations of these parameters investigated, particularly their association with overall survival, are warranted.
Architecture and performance models for QoS-driven effective peering of content delivery networks

The proprietary nature of existing Content Delivery Networks (CDNs) means they are closed and do not naturally cooperate. A CDN is expected to provide high performance Internet content delivery through global coverage, which might be an obstacle for new CDN providers, as well as affecting commercial viability of existing ones. Finding ways for distinct CDNs to coordinate and cooperate with other CDNs is necessary to achieve better overall service, as perceived by end-users, at lower cost. In this paper, we present an architecture to support peering arrangements between CDNs, based on a Virtual Organization (VO) model. Our approach promotes peering among providers, while upholding user perceived performance. This is achieved through proper policy management of negotiated Service Level Agreements (SLAs) between peers. We also present a Quality of Service (QoS)-driven performance modeling approach for peering CDNs in order to predict the user perceived performance. We show that peering between CDNs upholds user perceived performance by satisfying the target QoS. The methodology presented in this paper provides CDNs a way to dynamically distribute user requests to other peers according to different request-redirection policies. The model-based approach helps an overloaded CDN to return to a normal state by offloading excess requests to the peers. It also assists in making concrete QoS guarantee for a CDN provider. Our approach endeavors to achieve scalability and resource sharing among CDNs through effective peering in a user transparent manner, thus evolving past the current landscape where non-cooperative and distinct} CDNs exist.
Changes in bone remodelling and antifracture efficacy of intermittent bisphosphonate therapy: implications from clinical studies with ibandronate

Bisphosphonates reduce the rate of bone resorption and bone remodelling. Given daily, they decrease the risk of fractures in postmenopausal osteoporosis. When bisphosphonates were given at extended drug-free intervals this antifracture efficacy was generally not seen. This may be due to the different pattern of bone remodelling changes. Data from randomised clinical studies of ibandronate, given orally or intravenously, at different doses and for variable time intervals to women with osteoporosis were examined to explore the relationship between intermittent bisphosphonate therapy, changes in bone resorption and fracture risk. The magnitude of the reduction of the rate of bone resorption at the end of the drug-free interval rather than its fluctuation pattern after bisphosphonate administration determines antifracture efficacy, provided that these fluctuations occur within the premenopausal range. Prolongation of the drug-free interval beyond 2 weeks should be compensated by a dose higher than the cumulative daily dose.
Invasive neuroendocrine tumor of the kidney: a case report

Neuroendocrine tumors (NETs) involve the genitourinary system in less than 1% of cases, with primary renal carcinoids comprising only 19% of reported genitourinary NETs (56 cases worldwide). We report a case of a renal NET presenting as a large renal mass with extensive local invasion, requiring definitive radical en bloc resection via a thoracoabdominal approach.
A scalable distributed QoS multicast routing protocol

Many Internet multicast applications such as teleconferencing and remote diagnosis have quality-of-service (QoS) requirements. It is a challenging task to build QoS constrained multicast trees with high performance, high success ratio, low overhead, and low system requirements. This paper presents a new scalable QoS multicast routing protocol (SoMR) that has very small communication overhead and requires no state outside the multicast tree. SoMR achieves the favorable tradeoff between routing performance and overhead by carefully selecting the network sub-graph in which it conducts the search for a path that can support the QoS requirement, and by auto-tuning the selection according to the current network conditions. Its early-warning mechanism helps to detect and route around the real bottlenecks in the network, which increases the chance of finding feasible paths for additive QoS requirements. SoMR minimizes the system requirements; it relies only on the local state stored at each router. The routing operations are completely decentralized.
Functional connectivity during a social emotion task in adolescents and in adults

In this fMRI study we investigated functional connectivity between components of the mentalising system during a social emotion task, using psychophysiological interaction (PPI) analysis. Ten adults (22–32 years) and 18 adolescents (11–18 years) were scanned while thinking about scenarios in which a social or a basic emotion would be experienced. Unlike basic emotions (such as disgust and fear), social emotions (such as embarrassment and guilt) require the representation of another’s mental states. In both adults and adolescents, an anterior rostral region of medial prefrontal cortex (arMPFC) involved in mentalising showed greater connectivity with the posterior superior temporal sulcus (pSTS) bordering on the temporo‐parietal junction (TPJ) and with anterior temporal cortex (ATC) during social than during basic emotion. This result provides novel evidence that components of the mentalising system interact functionally during a social emotion task. Furthermore, functional connectivity differed between adolescence and adulthood. The adolescent group showed stronger connectivity between arMPFC and pSTS/TPJ during social relative to basic emotion than did the adult group, suggestive of developmental changes in functional integration within the mentalising system.
Modelling declassification policies using abstract domain completeness

This paper explores a three dimensional characterisation of a declassification-based non-interference policy and its consequences. Two of the dimensions consist of specifying: (a) the power of the attacker, that is, what public information a program has that an attacker can observe; and(b) what secret information a program has that needs to be protected. Both these dimensions are regulated by the third dimension: (c) the choice of program semantics, for example, trace semantics or denotational semantics, or any semantics in Cousot's semantics hierarchy. To check whether a program satisfies a non-interference policy, one can compute an abstract domain that over-approximates the information released by the policy and then check whether program execution can release more information than permitted by the policy. Counterexamples to a policy can be generated by using a variant of the Paige–Tarjan algorithm for partition refinement. Given the counterexamples, the policy can be refined so that the least amount of confidential information required for making the program secure is declassified.
Bone mineral density in Crohn's disease: a longitudinal study of budesonide, prednisone, and nonsteroid therapy

OBJECTIVE:Corticosteroids may contribute to the bone loss associated with Crohn's disease (CD). We investigated the effect on bone mineral density (BMD) of treatment with budesonide, a steroid with low systemic activity, and compared the outcome with prednisone and nonsteroid therapy in patients with CD.METHODS:Prospective annual BMDs of the lumbar spine (LS) and femoral neck (FN) were measured for 2 yr in 138 patients with quiescent CD treated with mean daily doses of 8.5 mg of budesonide (n = 48), 10.5 mg of prednisone (n = 45), or nonsteroid drugs (n = 45). RESULTS:Between baseline and 1 yr, the mean LS BMD decreased 2.36% in the budesonide group (p < 0.001), 0.61% in the prednisone group (ns), and 0.09% in the nonsteroid group (ns). The difference between budesonide and nonsteroid groups was significant (p = 0.003). In the 2nd yr, LS BMD did not change in the three groups. After 2 yr, FN BMD decreased 2.94% in the budesonide group (p < 0.01), 0.36% in the prednisone group (ns), and 1.05% in the nonsteroid group (ns); the differences among groups were not significant. The proportion of patients with bone loss of >2% per annum at the LS and FN was higher in the budesonide group than in the nonsteroid group (p < 0.001) and prednisone group (p < 0.05). CONCLUSIONS:Patients with CD receiving maintenance treatment for 2 yr with prednisone show little change in BMD, whereas treatment with budesonide may be associated with LS and FN bone loss. Budesonide does not confer an advantage over low-dose prednisone for the preservation of BMD.
A novel blood tool of cancer prognosis in esophageal squamous cell carcinoma: the Fibrinogen/Albumin Ratio

Background: Coagulation and nutrition play important roles in cancer progression. We aim to investigate the impact of the fibrinogen/albumin ratio(FAR) in esophageal squamous cell carcinoma (ESCC) patients. Methods: We retrospectively analyzed 1135 patients with radical esophagectomy for ESCC from January 2008 to December 2010 in our center. X-tile software was used to determine the optimal cutoff levels for these biomarkers. Results: The optimal cutoff value was 0.08 for the FAR by the X-tile software. The FAR was statistically significantly associated with age(p=0.003), sex(p=0.030), tumor length (p=0.043), pT status(p<0.001) and pN status(p<0.001). Pearson's correlation indicated that the FAR were positively associated with the serum C-reactive protein (CRP) ( r=0.583, p<0.001), and the NLR ( r=0.316, p<0.001). Multivariate analysis indicated that age, tumor grade, pT status, pN status and preoperative FAR were independent prognostic factors in patients with ESCC. Conclusions: Preoperative FAR was an independent prognostic factor in ESCC patients. Lower FAR may improve OS of ESCC patients.
Patterns of neuropsychological impairment in frontotemporal dementia

Objective: To differentiate frontotemporal dementia (FTD) subtypes from each other and from probable Alzheimer disease (AD) using neuropsychological tests. Methods: Patients with FTD and AD (n = 109) were studied with a comprehensive neuropsychological protocol at first contact. Data were subjected to a principal components analysis (PCA) to extract core neuropsychological features. A five-factor solution accounted for 72.89% of the variance and yielded factors related to declarative memory, working memory/visuoconstruction, processing speed/mental flexibility, lexical retrieval, and semantic memory. Results: Between- and within-group analyses revealed that patients with AD obtain their lowest scores on tests of declarative memory while semantic dementia (SemD) patients are particularly disadvantaged on tests of semantic memory. On tests of processing speed/mental flexibility time to completion was faster for social comportment/dysexecutive (SOC/EXEC) patients, but these patients made more errors on some tests. Patients with corticobasal degeneration (CBD) and progressive nonfluent aphasia (PNFA) were impaired on tests of working memory. Logistic regression analyses using factor scores successfully assigned FTD subgroups and AD patients into their respective diagnostic categories. Conclusion: Patients with differing frontotemporal dementia phenotypes can be distinguished from each other and from Alzheimer disease using neuropsychological tests.
Etudes expérimentales et numériques de la dynamique des vagues et leurs implications pour les échanges océan - atmosphère.

Au cours des dernieres decennies, les communautes de recherches oceanographiques et atmospherique ont demontrees que pour ameliorer notre comprehension du couplage entre l'atmosphere et l'ocean, et le parametrage du flux de masse entre l'ocean et l'atmosphere (gaz, aerosols, par exemple) , de moment (pour la generation de vagues et de courants marins) et d'energie (flux de chaleur et energie cinetique pour les courants et le processus de melange pres de la surface ) dans les modeles couples ocean-atmosphere, les vagues doivent etre prises en compte. La physique du couplage depend de la cinematique et de la dynamique du champ de vagues, y compris les processus de generation de vagues liees au vent, les interactions non-lineaires, ondes-ondes et la dissipation des vagues, cette derniere etant normalement consideree comme dominee par le deferlement. Nous presentons ici une serie d'etudes experimentales et numeriques, demontrant l'importance du champ de vagues sur les interactions ocean - atmosphere.
Association Between Thyroid and Iron Status of Pregnant Women in Southern Bulgaria

The purpose of this study was to assess the thyroid and iron status of pregnant women on the basis of biochemical indicators and to look for correlation dependences amongst them. A subject of this research were 128 pregnant women from Plovdiv, Southern Bulgaria. For the assessment of the iron status the following indicators were examined: hemoglobin (Hb), serum ferritin (SF), soluble transferrin receptors (sTfR), Body iron(mg/kg), defined by the formula:–[log(sTfR/SF)-2.8229]/0.1207. To assess the thyroid status the urinary iodine concentration was examined, and also the thyroid stimulating hormone (TSH) and free T4 (FT4). The results demonstrated that more than 1/3 of the examined pregnant women had Hb<110 g/L, and 69% had SF less than 15 µg/L, which is indicative for iron deficiency, 18.5% were with Body iron<0 mg/kg (indicate tissue iron deficiency). During the assessment of the thyroid status on the basis of ioduria it turned out that more than half of the pregnant women (59.3%) had iodine deficiency, 5.8% and respectively 19.0% had deviation in the values of TSH and FT4. In conclusion we can summarize that we have found out significant associations between iron deficiency with pregnant women and deviations in their thyroid status, which provides us with a solid base to continue and deepen the research in this direction.
Nasal Carriage of Staphylococcus aureus: Frequency and Antibiotic Resistance in Healthy Ruminants

Background: Staphylococcus aureus is a significant pathogen that can colonize the nares of different animals, causing a wide range of infections in various hosts. Objectives: We intended to determine the prevalence of S. aureus in the nasal cavity of healthy ruminants and also to investigate the presence of antibiotic resistance genes. Materials and Methods: In the present study, healthy cattle (n = 79), sheep (n = 78) and goats (n = 44) were screened for nasal carriage of S. aureus by the Polymerase Chain Reaction (PCR). Staphylococcus aureus isolates were further assessed for the presence of blaZ (encoding penicillin resistance), mecA (encoding methicillin resistance), tetK and tetM (encoding tetracycline resistance), and ermA and ermC (encoding macrolide-lincosamide-streptogramin B resistance) genes. Results: The proportion of S. aureus-positive nasal swabs from cattle, sheep and goats were four (5.06%), 11 (14.1%) and 11 isolates (25%), respectively. The blaZ gene was detected in 20 out of 26 S. aureus isolates (76.9%), including four cattle (100%), nine sheep (81.8%) and seven goats (63.6%). Two of the four cattle isolates possessing the blaZ gene also had the tetK gene. Of the nine sheep isolates harboring the blaZ gene, one possessed the mecA and tetK genes together. Of the seven goat isolates with blaZ gene, one harbored the tetM gene. None of the S. aureus isolates were positive for the ermA and ermC genes. Conclusions: In contrast to cattle, S. aureus is frequently present in the nose of sheep and goats, which may represent the primary reservoir of S. aureus in small ruminant flocks. This study also showed that nasal isolates of S. aureus from healthy ruminants might be a potential reservoir of antimicrobial-resistance.
Single target tracking using adaptive clustered decision trees and dynamic multi-level appearance models

This paper presents a method for single target tracking of arbitrary objects in challenging video sequences. Targets are modeled at three different levels of granularity (pixel level, parts-based level and bounding box level), which are cross-constrained to enable robust model relearning. The main contribution is an adaptive clustered decision tree method which dynamically selects the minimum combination of features necessary to sufficiently represent each target part at each frame, thereby providing robustness with computational efficiency. The adaptive clustered decision tree is implemented in two separate parts of the tracking algorithm: firstly to enable robust matching at the parts-based level between successive frames; and secondly to select the best superpixels for learning new parts of the target. We have tested the tracker using two different tracking benchmarks (VOT2013-2014 and CVPR2013 tracking challenges), based on two different test methodologies, and show it to be significantly more robust than the best state-of-the-art methods from both of those tracking challenges, while also offering competitive tracking precision.
Prognostic value of programmed cell death-ligand 1 expression in patients with non-small-cell lung cancer: evidence from an updated meta-analysis

Background The association between the expression of programmed cell death-ligand 1 (PD-L1) and survival in patients with non-small-cell lung cancer (NSCLC) is controversial. Thus, we conducted a meta-analysis of all available studies to evaluate the prognostic role of PD-L1 expression in NSCLC. Materials and methods PubMed, Embase, and Chinese (China National Knowledge Infrastructure and Wanfang) databases were searched to identify all eligible studies evaluating PD-L1 expression and the survival of NSCLC patients. Hazard ratios (HRs) and 95% confidence interval (CI) used to assess overall survival were extracted and pooled. Subgroup, sensitivity, and publication-bias analyses were also performed. Results Eleven articles reporting 12 studies that included a total of 1,653 patients met the inclusion criteria and were included in the meta-analysis. Higher PD-L1 expression did not correlate with prognosis in terms of overall survival in patients with NSCLC (HR =1.21, 95% CI: 0.85–1.71, P=0.29). However, a subgroup analysis showed a significant association between PD-L1 expression and poor prognosis in Chinese patients with NSCLC (HR =1.55, 95% CI: 1.04–2.29, P=0.03). The sensitivity analysis showed that the pooled results were not affected by the removal of any single study. There was also no significant publication bias. Conclusion Our meta-analysis indicated no statistically significant difference between PD-L1 expression and prognosis for patients with NSCLC. Additional, high-quality studies with larger sample sizes are needed to determine the prognostic value of PD-L1 expression in NSCLC.
Changes in Sensitivity to Effectors of Maize Leaf Phosphoenolypyruvate Carboxylase during Light/Dark Transitions.

Illumination of previously darkened maize (Zea mays L. cv Golden Cross Bantam T51) leaves had no effect on the concentration of phosphoenolpyruvate (PEP) carboxylase protein, but increased enzyme activity about 2-fold when assayed under suboptimal conditions (pH 7.0 and limiting PEP). In addition, sensitivity to effectors of PEP carboxylase activity was significantly altered; e.g. malate inhibition was reduced and glucose-6-phosphate activation was increased. Consequently, 10- to 20-fold differences in PEP carboxylase activity were observed during dark to light transitions when assayed in the presence of effectors. At pH 7.0 activity of purified PEP carboxylase was not proportional to enzyme concentrations. Below 0.7 microgram PEP carboxylase protein per milliliter, enzyme activity was disproportionately reduced. Including polyethylene glycol plus potassium chloride in the reaction mixture eliminated this discontinuity and substantially increased PEP carboxylase activity and reduced malate inhibition dramatically. Inclusion of polyethylene glycol in the assay mixture specifically increased the activity of PEP carboxylase extracted from dark leaves, and reduced malate inhibition of the enzyme from both light and dark leaves. Collectively, the results suggest that PEP carboxylase in maize leaves is subjected to some type of protein modification that affects both activity and effector sensitivity. We postulate that changes in quaternary structure (dissociation or altered subunit interactions) may be involved.
Secret Key Generation in the Two-Way Relay Channel With Active Attackers

Most of the existing work on key generation from wireless fading channels requires a direct wireless link between legitimate users so that they can obtain correlated observations from the common wireless link. This paper studies the key generation problem in the two-way relay channel, in which there is no direct channel between the key generating terminals. We propose an effective key generation scheme that achieves a substantially larger key rate than that of a direct channel mimic approach. Unlike existing schemes, there is no need for the key generating terminals to obtain correlated observations in our scheme. We also investigate the effects of an active attacker on the proposed key generation protocol. We characterize the optimal attacker's strategy that minimizes the key rate of the proposed scheme. Furthermore, we establish the maximal attacker's power under which our scheme can still achieve a nonzero key rate.
Relationship Violence Among Young Adult Couples

O The prevalence of violence in romantic relationships is difficult to measure. In part, this reflects the fact that men and women who experience violence in their relationships may be reluctant to report these acts because they want to protect a partner; they may assume that nothing can be done to prevent future violent acts; and they may fear retaliation.6 Moreover, most surveys of relationship violence provide a limited picture of the scope of the problem because they only gather information on the most severe types of violence or they rely solely on the report of one partner—typically the woman.5