Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Uncertain Electrical Properties on the Conditions for the Onset of Electroporation in an Eukaryotic Cell

A detailed numerical investigation concerning the influence on the electrical response of an eukaryotic cell model due to the variations of the conductivity and permittivity of the plasma and nuclear membranes is carried out by means of a vertex analysis. The dynamics of three cell performances, the voltages across the external and the nuclear membrane, and the pores density are analyzed by adopting a novel FEM-based model coupled with the nonlinear equation describing the electroporation (EP) phenomenon. The variations of the electrical and morphological performances, when the cell is stressed by a nonideal step input, are studied in three interesting regimes, i.e., at the nominal threshold for the onset of EP, and when the applied stress is over or under the EP threshold. The performed numerical analysis puts in evidence that, around the nominal EP threshold, uncertainties may lead to an indeterminate state of the plasma membrane, whereas the other two regimes remain well definite.
What dentition assures oral function?

OBJECTIVE To evaluate the relationship between dentition and oral function. MATERIAL AND METHODS A search of the English literature was undertaken using PubMed and appropriate keywords. Citations were identified and hand sorted to confirm their validity against our inclusion criteria. Four specific areas of oral function were addressed; (I) masticatory function, (II) aesthetics, satisfaction and psychosocial ability, (III) occlusal support and stability and (IV) other functionality including tactile perception, phonetics and taste. RESULTS From an initial pool of 1460 citations, 83 articles met the inclusion criteria. These were summarized and relevant data extracted for incorporation into the review. Masticatory efficiency (assessed as comminution efficiency) and masticatory ability (self-reported) are both linked to the number of teeth. A minimum of 20 teeth with nine to 10 pairs of contacting units (including anterior teeth) is associated with adequate efficiency and ability. Tooth numbers below that level yield impaired masticatory efficiency and are likely to result in reduction in reported masticatory ability. Aesthetics and satisfaction are markedly impaired with loss of anterior teeth. Satisfaction is most likely to be achieved in people who also retain a premolar dentition. Further, there is little increase in satisfaction seen in subjects who retained molar teeth. However, there are marked variations in subjective measures of aesthetics and psychosocial comfort between age groups, social classes, cultures, regions and countries. For most people, occlusal support and stability are obtained with three to four functional posterior units with a symmetrical pattern of tooth loss or five to six units with an asymmetrical pattern. There was no relationship between occlusal factors and symptoms of temporomandibular dysfunction. Phonetics may be maintained even with large anterior restorations. Patients generally attribute a low significance to phonetics, tactile perception and taste compared with mastication and appearance. CONCLUSIONS The World Health Organization goal for the year 2000, namely to maintain a natural dentition of not less than 20 teeth throughout life, is substantiated by the current literature review as this proposed dentition will assure an acceptable level of oral function.
Connecting and separating mind-sets: culture as situated cognition.

UNLABELLED People perceive meaningful wholes and later separate out constituent parts (D. Navon, 1977). Yet there are cross-national differences in whether a focal target or integrated whole is first perceived. Rather than construe these differences as fixed, the proposed culture-as-situated-cognition model explains these differences as due to whether a collective or individual mind-set is cued at the moment of observation. Eight studies demonstrated that when cultural mind-set and task demands are congruent, easier tasks are accomplished more quickly and more difficult or time-constrained tasks are accomplished more accurately ( STUDY 1 Koreans, Korean Americans; STUDY 2: Hong Kong Chinese; STUDY 3: European- and Asian-heritage Americans; STUDY 4: Americans; STUDY 5 Hong Kong Chinese; STUDY 6: Americans; STUDY 7: Norwegians; STUDY 8: African-, European-, and Asian-heritage Americans). Meta-analyses (d = .34) demonstrated homogeneous effects across geographic place (East-West), racial-ethnic group, task, and sensory mode-differences are cued in the moment. Contrast and separation are salient individual mind-set procedures, resulting in focus on a single target or main point. Assimilation and connection are salient collective mind-set procedures, resulting in focus on multiplicity and integration.
Reasons for Permanent Tooth Extractions in Japan

BACKGROUND There has been no nationwide study in Japan on reasons for extraction of permanent teeth. This survey was aimed to determine the reasons for extraction of permanent teeth in Japan. METHODS Five thousand, one hudred and thirty-one dentists were selected by systematic selection from the 2004 membership directory of the Japan Dental Association. The dentists selected were asked to record the reason for each extraction of permanent teeth during a period of one week from February 1 through 7, 2005. Reasons for tooth extraction were assigned to five groups: caries, fracture of teeth weakened by caries or endodontics, periodontal diseases, orthodontics, and other reasons. RESULTS A total of 2,001 dentists (response rate of 39.1%) returned the questionnaires, and information on 9,115 extracted teeth from 7,499 patients was obtained. The results showed that caries and its sequela (totally 43.3%, 32.7% and 10.6%, respectively) and periodontal disease (41.8%) were the main reasons for teeth extraction. Extraction due to caries or fracture was commonly observed in all age groups over 15 years of age, whereas periodontal disease was predominant in the groups over 45 years of age. CONCLUSIONS Most of the permanent teeth were extracted due to caries and its sequela and periodontal disease. Prevention and care for dental caries for all age groups and periodontal disease for over middle age groups are required.
The Compactness of Belief Revision and Update Operators

A propositional knowledge base can be seen as a compact representation of a set of models. When a knowledge base T is updated with a formula P, the resulting set of models can be represented in two ways: either by a theory T' that is equivalent to TaP or by the pair 〈T,P〉. The second representation can be super-polinomially more compact than the first. In this paper, we prove that the compactness of this representation depends on the specific semantics of a, e.g., Winslett's semantics is more compact than Ginsberg's.
Guidance ’ for Industry Statistical Aspects of the Design , Analysis , and Interpretation of Chronic Rodent Carcinogenicity Studies of Pharmaceuticals DRAFT GUIDANCE

Comments and suggestions regarding this draft document should be submitted within 90 days of publication in the Federal Register of the notice announcing the availability of the draft guidance. Submit comments to Dockets Management Branch (HFA-305), Food and Drug Administration, 12420 Parklawn Dr., rm. l-23, Rockville, MD 20857. All comments should be identified with the docket number listed in the notice of availability.
Antibiogram of bacteria isolated from automated teller machines in Hamadan, West Iran

Aim: Bacteria are ubiquitous in the environment. In keeping with the continued expansion of urbanization and the growing population, an increasing number of people use automated banking, i.e. automated teller machines (ATMs). The aim of this study was to investigate the bacterial contamination and its antibiotic sensitivity on computer keyboards located at ATMs in Hamadan province, Iran. Method: Out of 360 ATMs at four locations in Hamadan, 96 were randomly selected for this study. The antibiotic susceptibility pattern of all isolates was determined by the agar disk diffusion method using gentamicin (10 µg), vancomycin (30 µg), trimethoprim/sulfamethoxazole (25 µg), amikacin (30 µg), tobramycin (10 µg), cephalotin (30 µg), norfloxacin (5 µg), and ceftizoxim (30 µg) disks. Results: Melli and Saderat Banks had the most frequently contaminated ATMS, with 18 (27.7%) and 12 (18.5%), respectively. The most frequently isolated bacteria were Staphylococcus epidermidis in 12 (18.5%) ATMs, Pseudomonas aeruginosa in 12 (18.5%), Bacillus subtilis in 11 (16.9%), Escherichia coli in 6 (9.2%), Klebsiella spp. in 8 (12.3%), Enterobacter spp. in 2 (3.1%), Bacillus cereus in 6 (9.2%), Staphylococcus aureus in 3 (4.6%), and Micrococcaceae spp. in 5 (7.69%) cases. All isolated bacteria were susceptible to gentamicin, cephalotin, tobramycin, amikacin, norfloxacin, and vancomycin. The S. aureus resistance rate to trimethoprim/sulfamethoxazole was 50%. Conclusion: All tested ATM keyboards were contaminated with at least one species of bacteria. Based on these findings, it is recommendable to disinfect the hands after entering one’s own apartment, work area or a hospital, in order to hinder the spread of critical pathogens in the personal environment or in the hospital.
Comparison of gestural, touch, and mouse interaction with Fitts' law

We present preliminary results of an experiment to compare gestural, touch, and mouse interaction using Fitts' law. A total of 15 participants were asked to select 100 targets as quickly and accurately as possible using each technique. Selection of targets was split into rounds of 20 (separated by a short break) in order to evaluate whether fatigue affected performance or whether performance improved/declined over time. The results found that gestural interaction performed much worse than touch and mouse interaction and recorded 3 times as many miss-selections. The poor results for gestural interaction were attributed to participant unfamiliarity and inaccuracies of the gesture-sensing device (Microsoft Kinect). Touch interaction performed comparably with mouse interaction although suffered with smaller targets due to occlusion and the impreciseness of a finger compared to a mouse cursor. Overall, performance remained fairly consistent over subsequent rounds. Fatigue did not have any effect.
Genetic relationships of American alligator populations distributed across different ecological and geographic scales.

Although much work has been conducted on coastal populations of the American alligator (Alligator mississippiensis), less is known about the population dynamics and genetic structure of populations of alligators confined to inland habitats. DNA microsatellite loci, derived from the American alligator, were used to investigate patterns of genetic variation within and between populations of alligators distributed at coastal and inland localities in Texas. These data were used to evaluate the genetic discreteness of different alligator stocks relative to their basic ecology at these sites. Observed mean heterozygosities across seven loci for both coastal and inland populations ranged from 0.50-0.61, with both inland and coastal populations revealing similar patterns of variation. Measures of F(st) revealed significant population differentiation among all populations; however, analyses of molecular variance (AMOVAs) failed to demonstrate any apparent geographic pattern relative to the population differentiation indicated by F(st) values. Each population contained unique alleles for at least one locus. Additionally, assignment tests based on the distribution of genotypes placed 76% of individuals to their source population. These genetic data suggest considerable subdivision among alligator populations, possibly influenced by demographic and life history differences as well as barriers to dispersal. These results have clear implications for management. Rather than managing alligators in Texas as a single panmictic population, translocation programs and harvest quotas should consider the ecological and genetic distinctiveness of local alligator populations.
Detection of pancreatic cancer using antibody microarray‐based serum protein profiling

The driving force behind oncoproteomics is to identify protein signatures that are associated with a particular malignancy. Here, we have used a recombinant scFv antibody microarray in an attempt to classify sera derived from pancreatic adenocarcinoma patients versus healthy subjects. Based on analysis of nonfractionated, directly labeled, whole human serum proteomes we have identified a protein signature based on 19 nonredundant analytes, that discriminates between cancer patients and healthy subjects. Furthermore, a potential protein signature, consisting of 21 protein analytes, could be defined that was shown to be associated with cancer patients having a life expectancy of <12 months. Taken together, the data suggest that antibody microarray analysis of complex proteomes will be a useful tool to define disease associated protein signatures.
Changes in land cover, rainfall and stream flow in Upper Gilgel Abbay catchment, Blue Nile basin – Ethiopia

Abstract. In this study we evaluated changes in land cover and rainfall in the Upper Gilgel Abbay catchment in the Upper Blue Nile basin and how changes affected stream flow in terms of annual flow, high flows and low flows. Land cover change assessment was through classification analysis of remote sensing based land cover data while assessments on rainfall and stream flow data are by statistical analysis. Results of the supervised land cover classification analysis indicated that 50.9 % and 16.7 % of the catchment area was covered by forest in 1973 and 2001, respectively. This significant decrease in forest cover is mainly due to expansion of agricultural land. By use of a change detection procedure, three periods were identified for which changes in rainfall and stream flow were analyzed. Rainfall was analyzed at monthly base by use of the Mann-Kendall test statistic and results indicated a statistically significant, decreasing trend for most months of the year. However, for the wet season months of June, July and August rainfall has increased. In the period 1973–2005, the annual flow of the catchment decreased by 12.1 %. Low flow and high flow at daily base were analyzed by a low flow and a high flow index that is based on a 95 % and 5 % exceedance probability. Results of the low flow index indicated decreases of 18.1 % and 66.6 % for the periods 1982–2000 and 2001–2005 respectively. Results of high flows indicated an increase of 7.6 % and 46.6 % for the same periods. In this study it is concluded that over the period 1973–2005 stream flow has changed in the Gilgel Abbay catchment by changes in land cover and changes in rainfall.
Multicenter study of pegylated liposomal doxorubicin in patients with cutaneous T‐cell lymphoma

In single center studies and case reports, it was shown that pegylated liposomal doxorubicin (PEG‐DOXO) was effective as second‐line therapy for patients with cutaneous T‐cell lymphoma (CTCL). The objective of this study was to evaluate the efficacy and toxicity of single‐agent PEG‐DOXO as second‐line chemotherapy in patients with CTCL.
Nitric Oxide and Fetal Organ Blood Flow During Normoxia and Hypoxemia in Endotoxin-Treated Fetal Sheep

OBJECTIVE: To investigate the role of nitric oxide in the process of circulatory decentralization during fetal hypoxemia. METHODS: Fifteen sheep with singleton pregnancies were chronically instrumented at 107 days of gestation (term is 147 days). Three days later, 8 of the fetuses received nitro-l-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthesis. Fifteen minutes after L-NAME administration, all 15 fetuses received lipopolysaccharides (LPS) from a strain of Escherichia coli. The 7 fetuses that received LPS only were used as controls. Sixty minutes after LPS was administered, the maternal aorta was occluded for 2 minutes in all fetuses. Organ blood flow and physiological variables were measured at 75 minutes before the start of occlusion (ie, at the time of L-NAME administration to the experimental group), at 1 minute before the start of occlusion, and at 2, 4, and 30 minutes after the start of occlusion. RESULTS: Arterial pH was lower in the L-NAME group than in the control group at 1 minute before and 2 minutes after occlusion. Mean arterial pressure was higher in the L-NAME group than in the control group at 2 and 4 minutes after occlusion. Cardiac output fell in the L-NAME group and was lower than in the control group; the percentage of cardiac output to the cerebrum in the L-NAME group was 35% lower than that in the control group. Throughout the study, placental blood flow decreased by more than 80% in both groups and remained low. Blood flow to the fetal body decreased by 65% in the L-NAME group and was lower than in the control group. Blood flow to the carcass also decreased in the L-NAME group and was 36% of that in the control group. CONCLUSION: Inhibition of nitric oxide synthesis causes a general vasoconstriction in practically all organs and leads to a reduction in LPS-induced circulatory decentralization. The changes in blood flow distribution in endotoxin-treated fetal sheep seem to be mediated in part by nitric oxide.
Homo Socialis - The Road Ahead

When I started the publication project with Herbert Gintis on the homo socialis (Gintis and Helbing, 2015), the most important motive for me was to trigger a scientific debate. So, from my perspective, our joint paper on the homo socialis is not to be seen as an end point or eternal truth, but as the starting point of a new theory for socio-economic systems. In this comment, I will expand on my paper with Herbert Gintis, and I will use the opportunity to present some further thoughts and materials.
Tumor Necrosis Factor Blockade in Chronic Murine Tuberculosis Enhances Granulomatous Inflammation and Disorganizes Granulomas in the Lungs

ABSTRACT Tumor necrosis factor (TNF) is a prototypic proinflammatory cytokine that contributes significantly to the development of immunopathology in various disease states. A complication of TNF blockade therapy, which is used increasingly for the treatment of chronic inflammatory diseases, is the reactivation of latent tuberculosis. This study used a low-dose aerogenic model of murine tuberculosis to analyze the effect of TNF neutralization on disease progression in mice with chronic tuberculous infections. Histological, immunohistochemical, and flow cytometric analyses of Mycobacterium tuberculosis-infected lung tissues revealed that the neutralization of TNF results in marked disorganization of the tuberculous granuloma, as demonstrated by the dissolution of the previously described B-cell-macrophage unit in granulomatous tissues as well as by increased inflammatory cell infiltration. Quantitative gene expression studies using laser capture microdissected granulomatous lung tissues revealed that TNF blockade in mice chronically infected with M. tuberculosis leads to the enhanced expression of specific proinflammatory molecules. Collectively, these studies have provided evidence suggesting that in the chronic phase of M. tuberculosis infection, TNF is essential for maintaining the structure of the tuberculous granuloma and may regulate the granulomatous response by exerting an anti-inflammatory effect through modulation of the expression of proinflammatory mediators.
Noise levels of dental equipment used in dental college of Damascus University

Background: In dental practical classes, the acoustic environment is characterized by high noise levels in relation to other teaching areas. The aims of this study were to measure noise levels produced during the different dental learning clinics, by equipments used in dental learning areas under different working conditions and by used and brand new handpieces under different working conditions. Materials and Methods: The noise levels were measured by using a noise level meter with a microphone, which was placed at a distance of 15 cm from a main noise source in pre-clinical and clinical areas. In laboratories, the microphone was placed at a distance of 15 cm and another reading was taken 2 m away. Noise levels of dental learning clinics were measured by placing noise level meter at clinic center. The data were collected, tabulated and statistically analyzed using t-tests. Significance level was set at 5%. Results: In dental clinics, the highest noise was produced by micro motor handpiece while cutting on acrylic (92.2 dB) and lowest noise (51.7 dB) was created by ultrasonic scaler without suction pump. The highest noise in laboratories was caused by sandblaster (96 dB at a distance of 15 cm) and lowest noise by stone trimmer when only turned on (61.8 dB at a distance of 2 m). There was significant differences in noise levels of the equipment's used in dental laboratories and dental learning clinics (P = 0.007). The highest noise level recorded in clinics was at pedodontic clinic (67.37 dB). Conclusions: Noise levels detected in this study were considered to be close to the limit of risk of hearing loss 85 dB.
Initial Data for Numerical Relativity

Initial data are the starting point for any numerical simulation. In the case of numerical relativity, Einstein’s equations constrain our choices of these initial data. We will examine several of the formalisms used for specifying Cauchy initial data in the 3 + 1 decomposition of Einstein’s equations. We will then explore how these formalisms have been used in constructing initial data for spacetimes containing black holes and neutron stars. In the topics discussed, emphasis is placed on those issues that are important for obtaining astrophysically realistic initial data for compact binary coalescence.
Maternal abortions and birth of Down syndrome offspring.

Various studies have shown a relation ship between maternal history of spontaneous abortion and still births of unknown karyotype and the risk of a subsequent Down Syndrome (DS) live birth(l/2). However, the results of these investigations have been inconclusive(3-6). The present study was, therefore, conducted to evaluate the association between the history of spontaneous abortion and birth of DS offspring.
Supporting common ground and awareness in emergency management planning

We present a design research project on knowledge sharing and activity awareness in distributed emergency management planning. In three experiments we studied groups using three different prototypes, respectively: a paper-prototype in a collocated work setting, a first software prototype in a distributed setting, and a second, enhanced software prototype in a distributed setting. In this series of studies we tried to better understand the processes of knowledge sharing and activity awareness in complex cooperative work by developing and investigating new tools that can support these processes. We explicate the design rationale behind each prototype and report the results of each experiment investigating it. We discuss how the results from each prototyping phase brought us closer to defining properties of a system that facilitate the sharing and awareness of both content and process knowledge. Our designs enhanced aspects of distributed group performance, in some respects beyond that of comparable face-to-face groups.