Miracle-dz/UniFAR-FTUs huggingface dataset:
El engagement en el trabajo. Cuando el trabajo se convierte en pasión

The book discusses concerns about the engagement, which, according to the authors, occupational health and related human resource management from a positive approach. Derive from it two key concepts: the empowerment and employability. This review will leave from such conceptual basis for nuancing their impact on the field of occupational health from a preventive perspective. It will analyze how the engagement (including social contagion or collectivization) contribute to creating healthy organizations in the world of work, just at the opposite burnout syndrome, as evidenced by the classic demands-resources model. In this light, work organization, on the one hand, be decisive, and secondly, in terms of personal resources, the authors also remarked the decisive role of self-efficacy. A bet, in essence, for holistic health.
Regulation of Neuronal Proapoptotic Potassium Currents by the Hepatitis C Virus Nonstructural Protein 5A

Apoptosis-enabling neuronal potassium efflux is mediated by an enhancement of K+ currents. In cortical neurons, increased currents are triggered by dual phosphorylation of Kv2.1 by Src and p38 at channel residues Y124 and S800. It was recently shown that a K+ current surge is also present in hepatocytes undergoing apoptosis, and that the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) could inhibit Kv2.1-mediated currents and block cell death. Here, we show that NS5A1b (from HCV genotype 1b) expression in rat neurons depresses delayed rectifier potassium currents, limits the magnitude of the K+ current surge following exposure to activated microglia, and is neuroprotective. In a non-neuronal recombinant expression system, cells expressing Kv2.1 mutated at residue Y124, but not S800 mutants, are insensitive to NS5A1b-mediated current inhibition. Accordingly, NS5A1b coexpression prevents phosphorylation of wild-type Kv2.1 by Src at Y124, but is unable to inhibit p38 phosphorylation of the channel at S800. The actions of the viral protein are genotype-selective, as NS5A1a does not depress neuronal potassium currents nor inhibit Src phosphorylation of Kv2.1. Our results indicate that NS5A1b limits K+ currents following injury, leading to increased neuronal viability. NS5A1b may thus serve as a model for a new generation of neuroprotective agents.
Effect of 6 months of exercise and isoflavone supplementation on clinical cardiovascular risk factors in obese postmenopausal women: a randomized, double-blind study

Objective:To investigate whether 6 months of exercise combined with isoflavone supplementation could improve clinical risk factors that predispose to cardiovascular disease in obese postmenopausal women. Design:This was a randomized, double-blind, controlled trial in which 50 healthy obese postmenopausal women were divided into two groups and assigned to isoflavone supplementation (n = 25) or a placebo (n = 25) for 1 year. For the last 6 months, both groups participated in an exercise program (three times per week), at the end of which cardiovascular disease risk factors were compared between groups. Body composition (using dual-energy x-ray absorptiometry), metabolic profile (blood lipids, fasting insulin, fasting glucose, sex hormone-binding globulin, C-reactive protein) were determined at baseline and at 6 and 12 months. Results:We observed a significant effect of exercise and isoflavone supplementation on body weight, total and abdominal fat mass (kilograms and percentage), body mass index, appendicular fat-free mass, fat-free mass/fat mass ratio, and sex hormone-binding globulin, but not with exercise alone. No difference was observed for other biochemical characteristics, although the quantitative insulin sensitivity check index increased equally in both groups. Conversely, although not significant, we observed a tendency for a treatment effect on body mass index (P = 0.07) and on absolute (kilograms) (P = 0.07) and percentage of (P = 0.053) abdominal fat mass, whereas no effect of treatment was found for other variables using the Mann-Whitney test. Conclusions:Compared to an aerobic exercise program alone, 70 mg/day of isoflavones combined with exercise may promote significant improvements in body composition parameters that are known to influence cardiovascular disease risk in postmenopausal women.
Concurrent validity and responsiveness of the Peabody Developmental Motor Scales-2 in infants and children with Pompe disease undergoing enzyme replacement therapy

Purpose: To examine the responsiveness of the PDMS-2 in children diagnosed with Pompe disease who had different levels of functional mobility. To examine the concurrent validity between the PDMS-2 and the Alberta Infant Motor Scale (AIMS), the Pediatric Evaluation of Disability Inventory (PEDI) and the Pompe PEDI (PPEDI) in children diagnosed with Pompe disease. Methods: A secondary analysis was completed of the Genzyme Corporation Pompe efficacy trials for Myozyme. The children were divided into two functional groups, independent ambulators (group 1), and children who required use of assistive devices to ambulate or were unable to ambulate (group 2). Results: A significant difference was present between the mean PDMS-2 subtest and Gross Motor Composite percentage scores at baseline and at week 52 when the whole group was combined. Responsiveness measured by the factor of Time and Function revealed Locomotion subtest statistically significant mean percentage change within both functional groups from baseline to week 52 and between groups at both time periods. No significant within group or between group differences were seen for the Stationary subtest. The Object Manipulation iii subtest demonstrated significant change within group one from baseline to week 52 and between the functional presentations at week 52.The age equivalent correlations between the PDMS-2 and AIMS indicate a good to excellent relationship for all subtests except the Object Manipulation subtest. A four-month range in age equivalent scores was necessary to achieve 100% agreement between the AIMS and the PDMS-2. Correlations between the PDMS-2, Locomotion and Stationary subtest and PPEDI for all age groups were in the moderate to good and good to excellent range. Non-significant correlations were found for the Reflex and Object Manipulation subtest. Conclusions: The PDMS-2 gross motor subtests were responsive to change in a heterogeneous group of children diagnosed with Pompe disease. Responsiveness concerns were identified in the Object Manipulation and Stationary subtest when the children were divided into two different functional groups. A stronger relationship was present between the PDMS-2 and AIMS age equivalent scores than the percentile scores. Motor capacity on the PDMS-2 reflects actual performance in the home and community environment as measured by the PPEDI. iv Dedication This doctoral dissertation is dedicated to my husband Troy and our children Aubrie and Georgina. Without their support and encouragement completion of this dissertation would not have been possible. I am also grateful for my mother, Myrna and for the many friends who have supported me …
Dystrophies and Associated Crises in Research and Academic Publications in Nigerian Universities

Abstract The study investigated the dystrophies and associated crises in research and academic publications in Nigerian universities. A sample of 1,420 academic staff from the three categories of universities was made. The questionnaire titled “Academic Staff Questionnaire on Associated Crisis in Research and Publication” was the instrument employed to collect data which were later analysed using simple percentage statistical tool. The result revealed that: lack of utility of research outcome and feedback, non-involvement of research findings consumers in research activities, lack of centres for research findings dissemination, exodus of outstanding scholars from the system (brain-drain); lack of adequate funds for research; obsolete library and laboratory/workshop facilities; ignorance of foreign research outcomes; lack of adequate remuneration for researchers; leadership-associated problems as well as “Publish or Perish” syndrome were identified by more than 50% of the respondents as sources of dystrophic problems in research and publications among Nigerian academics. Arising from the above, some recommendations were made.
TOURISM, LOCAL ECONOMIC DEVELOPMENT AND INCLUSION: EVIDENCE FROM OVERSTRAND LOCAL MUNICIPALITY, SOUTH AFRICA

A critical focus within the growing scholarship around tourism development and planning is that of tourism and local economic development (LED) planning. This paper investigates the nexus of tourism and LED planning in South Africa. Arguably, South Africa provides fertile territory for exploring this relationship because of the national importance of tourism for the economy as a whole and of a policy commitment by national government to the support of sub-national development planning. Evidence is presented from the Overstrand Local Municipality in the Western Cape, one of many small towns where tourism is a critical local economic driver. The evidence shows that tourism expansion can contribute to enhanced growth of the local economy as well as job creation for local communities. This said, the existing ownership structure of the local tourism economy is massively weighted to white entrepreneurs such that the local tourism economy cannot be described as inclusive.
Detritus of Empire: Seventeenth Century Spanish Pottery from Taumako, Southeast Solomon Islands, and Mota, Northern Vanuatu

We describe here the recovery and analysis of exotic pottery from the island of Taumako in the Duff Islands of the Southeast Solomon Islands and from Mota in the Banks Islands, Northern Vanuatu. The pottery was found during archaeological fieldwork carried out in the 1970s. It comprises a single surface-collected sherd from Taumako, and half of an amphora-like jar from Mota. Historical records and petrographic analyses point to the two separate pottery samples being non-Oceanic, almost certainly originally sourced from the Spanish colonial industries of Peru, and that they are most likely associated with the 1605-6 Spanish expedition to the Pacific led by the Portuguese navigator Don Pedro Ferdinand De Quiros. The archaeological remains and historic documents also provide further evidence of the strong indigenous inter-island connections of the period.
Undergraduate Level EFL Student‘s Beliefs About LanguageLearning

By providing quantitative data from the modified EFL version of Beliefs about Language Learning Inventory (BALLI) completed by the ELT undergraduate level students in one of the Turkish Universities, the survey was aimed to obtain generalizable conclusions about beliefs or notions about language learning of undergraduate level EFL students. The relationships among gender and years of education in the ELT department, as the impacting factors, and the participants‘ scores in the BALLI were statistically analyzed. The results were discussed in terms of the EFL students‘ the most important beliefs and the effect size of the gender and years of education as the variables on their beliefs about language learning.
PENGARUH KEPEMIMPINAN TRANSFORMASIONAL TERHADAP KEPUASAN KERJA DAN TURNOVER INTENTION PADA CV. GITA KARYA PERSADA DENPASAR

Tujuan penelitian ini adalah untuk mengetahui pengaruh kepemimpinan transformasional terhadap kepuasan kerja karyawan, dan turnover intention , pada CV. Gita Karya Persada. Penelitian ini merupakan penelitian asosiatif , menggunakan metode kuantitatif serta mengunakan metode sensus dalam menentukan sampel. Kuesioner digunakan sebagai instrumen utama penelitian ini dan analisis data menggunakan analisis jalur . Hasil penelitian menunjukkan kepemimpinan transformasional berpengaruh positif dan siginfikan terhadap kepuasan kerja karyawan sebesar 33,1 persen. Kepemimpinan transformasional berpengaruh negatif dan siginfikan terhadap turnover intention . Dengan pengaruh langsung sebesar 3 persen. Dan pengaruh tidak langsung sebesar 9 persen. Total pengaruh kepemimpinan transformasional terhadap turnover intention sebesar 90 persen. Kepuasan kerja berpengaruh negatif dan siginfikan terhadap turnover intention dengan besar pengaruh langsung sebesar 77 persen.
Countering Anti-Immigrant Discourses in the New Latino South: “Nos mascan pero no nos tragan”

The increased visibility of immigrant communities in the southeastern United States coupled with the economic recession has led to a proliferation of anti-immigrant policies and contributed to a climate which positions Latin@ immigrants and the Spanish language as foreign or threatening. In this article, we examine language ideologies related to Latin@ immigrants that are prevalent in rural communities in North Carolina. We explore which language ideologies circulate and how these are incorporated into coherent Discourses. Data for this qualitative study include 42 in-depth interviews with immigrant and nonimmigrant residents. Findings indicate tensions between the ideologies of English monolingualism as inherently American and individual self-determination, including language choice, as integral to Appalachian culture. Although current social policies seek to marginalize immigrant communities, many participants worked to dispel negative perceptions of immigrants, challenge dominant Discourses that circumscribe Latin@ identity, and develop understanding between local residents and the immigrant community.
Effects of tolcapone in Parkinson's patients taking L‐dihydroxyphenylalanine/carbidopa and selegiline

A double‐blind, placebo‐controlled, crossover trial of tolcapone (RO 407592), a potent reversible inhibitor of catechol‐O‐methyltransferase (COMT), was performed in 10 Parkinson's disease (PD) patients to determine single‐dose safety and efficacy. All subjects were chronically treated with stable doses of selegiline and L‐dihydroxyphenylalanine (L‐DOPA)/carbidopa. Tolcapone was administered in four single ascending doses (50‐800 mg) randomly paired with placebo. Motor ratings were performed every 30 min for 6 h. At higher doses (400 mg and 800 mg), tolcapone prolonged the antiparkinson response of L‐DOPA. Nausea was the most common adverse effect of the tolcapone—L‐DOPA/carbidopa—selegiline combination. Adverse cardiovascular effects were not seen. The acute inhibition of amino acid decarboxylase, monoamine oxidase‐B, and COMT is well tolerated and prolongs the L‐DOPA response in PD patients. Tolcapone may be a safe and useful adjunct to L‐DOPA/carbidopa in PD patients taking selegiline.
Structural Propensities of Human Ubiquitination Sites: Accessibility, Centrality and Local Conformation

The existence and function of most proteins in the human proteome are regulated by the ubiquitination process. To date, tens of thousands human ubiquitination sites have been identified from high-throughput proteomic studies. However, the mechanism of ubiquitination site selection remains elusive because of the complicated sequence pattern flanking the ubiquitination sites. In this study, we perform a systematic analysis of 1,330 ubiquitination sites in 505 protein structures and quantify the significantly high accessibility and unexpectedly high centrality of human ubiquitination sites. Further analysis suggests that the higher centrality of ubiquitination sites is associated with the multi-functionality of ubiquitination sites, among which protein-protein interaction sites are common targets of ubiquitination. Moreover, we demonstrate that ubiquitination sites are flanked by residues with non-random local conformation. Finally, we provide quantitative and unambiguous evidence that most of the structural propensities contain specific information about ubiquitination site selection that is not represented by the sequence pattern. Therefore, the hypothesis about the structural level of the ubiquitination site selection mechanism has been substantially approved.
Whose Deficit Is This Anyhow? Exploring Counter-Stories of Somali Bantu Refugees' Experiences in "Doing School"

In this article, Laura Roy and Kevin Roxas draw from two studies with Somali Bantu refugee families in South Texas and Michigan. Findings from both study sites revealed a disconnect between how educators perceived the Somali Bantu families' educational goals and Somali Bantu families' actual views of education. In contrast to educators' perceptions, Somali Bantu caregivers stressed the high value they placed on education through their storytelling practices in the home that related past struggles, including experiences of violence and poverty. The stories told and advice given by parents and elders showed an embedded value of education within the community and a counter-story to the way in which Somali Bantu families were viewed by the majority of their teachers. The authors conclude that the discourse employed by educators was grounded in a deficit-based paradigm that created missed opportunities for connecting with Somali Bantu parents and marginalized students by blaming them rather than evaluating the.
The verb use in Cantonese monolingual and Cantonese-English bilingual children

Past researches have showed that some bilingual children who acquired English and another European language demonstrated interdependent language development and a smaller vocabulary size. One case study on a Hong Kong simultaneous Cantonese-English bilingual child has presented evidence of syntactic transfer from Cantonese to English as well. The primary objective of current study was to investigate the Cantonese verb use and the aspect marker use of two groups of Cantonese-English bilinguals. For the verb use, it aimed at finding if the bilinguals have acquired fewer verbs than the monolinguals. The result of this study showed that successive bilinguals produced most different types of verbs than monolinguals while simultaneous bilinguals produced the least different types among three groups. The unexpected result of successive bilingual children was discussed in relation to the language dominance and social-economic status. For the aspect markers, it aimed at finding evidence of syntactic transfer from English and Cantonese. The comparison between two types of bilinguals did not show quantitative difference, but qualitative difference was evidenced as two simultaneous bilingual children demonstrated overgeneralization of aspect markers. The syntactic transfer from English to Cantonese accounted for this.
High-Rate Quantum Low-Density Parity-Check Codes Assisted by Reliable Qubits

Quantum error correction is an important building block for reliable quantum information processing. A challenging hurdle in the theory of quantum error correction is that it is significantly more difficult to design error-correcting codes with desirable properties for quantum information processing than for traditional digital communications and computation. A typical obstacle to constructing a variety of strong quantum error-correcting codes is the complicated restrictions imposed on the structure of a code. Recently, promising solutions to this problem have been proposed in quantum information science, where in principle any binary linear code can be turned into a quantum error-correcting code by assuming a small number of reliable quantum bits. This paper studies how best to take advantage of these latest ideas to construct desirable quantum error-correcting codes of very high information rate. Our methods exploit structured high-rate low-density parity-check codes available in the classical domain and provide quantum analogues that inherit their characteristic low decoding complexity and high error correction performance even at moderate code lengths. Our approach to designing high-rate quantum error-correcting codes also allows for making direct use of other major syndrome decoding methods for linear codes, making it possible to deal with a situation where promising quantum analogues of low-density parity-check codes are difficult to find.
Pass-Through as an Economic Tool: Principles of Incidence under Imperfect Competition

We extend five principles of tax incidence under perfect competition to a general model of imperfect competition. The principles cover (1) the independence of physical and economic incidence, the (2) qualitative and (3) quantitative manner in which taxes are split between consumers and producers, (4) the determinants of tax pass-through, and (5) the integration of local incidence to determine the overall division of surplus. We show how these principles can be used to simplify and generalize the analysis of a range of economic questions such as the optimal procurement of new markets and the welfare effects of third-degree price discrimination.
Major depression in community adolescents: age at onset, episode duration, and time to recurrence.

OBJECTIVE This paper presents retrospective and prospective data regarding time course parameters of major depressive disorder (MDD) in community adolescents (14 to 18 years old): time to onset and recovery and, among those who recovered, time to recurrence. METHOD Diagnostic interviews were conducted with 1,508 randomly selected high school students. Three hundred sixty-two had experienced at least one past or current episode of MDD. RESULTS Mean age at onset of first episode was 14.9 (SD = 2.8). Early MDD onset was associated with female gender and suicidal ideation. MDD episode duration ranged from 2 to 520 weeks, with a mean of 26.4 weeks (SE = 3.3) and a median of 8.0 weeks. Longer episodes were observed in those whose depression occurred early (at or before age 15), whose depression had been accompanied by suicidal ideation, and for whom treatment was sought. Of the adolescents who recovered, 5% relapsed within 6 months, 12% within 1 year, and approximately 33% within 4 years. Shorter time to recurrence was associated with prior suicidal ideation and attempt and with later first onset. CONCLUSIONS Risk of MDD is low in childhood, increasing substantially with adolescence. The majority of episodes in community adolescents are relatively brief, although the risk of recurrence is substantial. Suicidal behaviors are important mediators of episode duration and of recurrence.
Effect of sodium concentration in a carbohydrate-electrolyte solution on intestinal absorption.

Intestinal absorption during infusion (15 ml.min-1) of a 6% carbohydrate (2% glucose and 4% sucrose) solution containing either 0, 25 or 50 mEq.l-1 Na+ was measured by segmental perfusion with a triple lumen tube in males (age 24.3 +/- 1.6) at rest in a neutral environment (22 degrees C). Infusion of the 25 and 50 mEq.l-1 Na+ solutions was performed using a balanced design on the same day, separated by a 1-hr period of no infusion. Infusion of 0 mEq.l-1 Na+ solution was performed on a separate day. A 45-min equilibration period preceded a 90-min test session. Water and solute fluxes were determined from differences in concentration of polyethylene glycol and solute across a 40-cm intestinal segment of the duodenojejunum. A two-factor repeated measures ANOVA indicated no differences (P > 0.1) over time for water, Na+, or glucose flux for all solutions. Plasma volume increased (P < 0.01) approximately 5% over time for all solutions. We conclude that Na+ concentrations of 0, 25, or 50 mEq.l-1 in a 6% carbohydrate solution have similar effects on the absorption of water, Na+, and glucose from the duodenojejunum. Glucose in the infusion solution is the more important factor determining intestinal water absorption than Na+. This study suggests that adding Na+ to fluid replacement beverages may not be a factor in fluid absorption.