Miracle-dz/UniFAR-FTUs huggingface dataset:
OFFER: Off-Environment Reinforcement Learning

Policy gradient methods have been widely applied in reinforcement learning. For reasons of safety and cost, learning is often conducted using a simulator. However, learning in simulation does not traditionally utilise the opportunity to improve learning by adjusting certain environment variables - state features that are randomly determined by the environment in a physical setting but controllable in a simulator. Exploiting environment variables is crucial in domains containing significant rare events (SREs), e.g., unusual wind conditions that can crash a helicopter, which are rarely observed under random sampling but have a considerable impact on expected return. We propose off environment reinforcement learning (OFFER), which addresses such cases by simultaneously optimising the policy and a proposal distribution over environment variables. We prove that OFFER converges to a locally optimal policy and show experimentally that it learns better and faster than a policy gradient baseline.
Secondary Chromosome Changes in Mantle Cell Lymphoma: Cytogenetic and Fluorescence In Situ Hybridization Studies

To better define the incidence and nature of secondary chromosome anomalies in mantle cell lymphoma (MCL) carrying the t( 1 1 ;14)/BCLI rearrangement, cytogenetic and fluorescence in situ hybridization studies (FISH) were performed in 42 patients (39 classical histology, 3 blastoid variant), using 6q21, 9p2l/p16, 13q14, 17p13/p53 and chromosome-12-specific probes. Karyotypes from 89 cases published in 5 recent series including patients diagnosed in a homogeneous fashion were reviewed. In our series, FISH confirmed the interpretation of the karyotype in all cases and disclosed cryptic chromosome deletions in a sizeable fraction of cases. One patient (2.4% of total) was found with a cryptic 9p21 deletion by FISH. Two cases (4,8%) had a 6q21 deletion at CCA and at FISH; +12 was found in three cases by CCA plus nine by FISH (28.6%); 13q14 deletion was found in six cases by CCA plus 16 by FISH (52.4%), 1 7 ~ 1 3 deletion in three cases by CCA plus 8 by FISH (26.2%). In 13 1 patients (42 present series plus 89 in the literature) secondary chromosome aberrations seen by conventional cytogenetic analysis in more than 5 cases included deletions / translocations (del/t) 6q15-23 [15 cases]; -13 [ I4 cases]; deVt lp21-31 [12 cases]; +3q [ 1 1 cases]; del/t 17p [9 cases]; 8p translocations and del(Y) [8 cases each]; -20 [7 cases]; 13q14 deletion, deYt 1lq22-23, deUt 9q, deI(lO)(q22q24), -20, -21, -22 and -X [6 cases each]. We arrived at the following conclusions: i) though no secondary anomaly is specific for MCL, there is a distinct profile of recurrent chromosome lesions in MCL with lp21-31 deletions, 8p translocations, 11q22-23 anomalies having a strong association with CD5+ B-cell lymphomas of low-to-intermediate grade histology; ii) FISH enabled the detection of cryptic chromosome 12, 13q and 17p rearrangements in a sizeable fraction of cases; iii) 9p21/p16 deletions did not occur at a high incidence in this series, possibly because of the low number of cases with blastoid variant.
Fabrication and assessment of 3D printed anatomical models of the lower limb for anatomical teaching and femoral vessel access training in medicine

For centuries, cadaveric dissection has been the touchstone of anatomy education. It offers a medical student intimate access to his or her first patient. In contrast to idealized artisan anatomical models, it presents the natural variation of anatomy in fine detail. However, a new teaching construct has appeared recently in which artificial cadavers are manufactured through three‐dimensional (3D) printing of patient specific radiological data sets. In this article, a simple powder based printer is made more versatile to manufacture hard bones, silicone muscles and perfusable blood vessels. The approach involves blending modern approaches (3D printing) with more ancient ones (casting and lost‐wax techniques). These anatomically accurate models can augment the approach to anatomy teaching from dissection to synthesis of 3D‐printed parts held together with embedded rare earth magnets. Vascular simulation is possible through application of pumps and artificial blood. The resulting arteries and veins can be cannulated and imaged with Doppler ultrasound. In some respects, 3D‐printed anatomy is superior to older teaching methods because the parts are cheap, scalable, they can cover the entire age span, they can be both dissected and reassembled and the data files can be printed anywhere in the world and mass produced. Anatomical diversity can be collated as a digital repository and reprinted rather than waiting for the rare variant to appear in the dissection room. It is predicted that 3D printing will revolutionize anatomy when poly‐material printing is perfected in the early 21st century. Anat Sci Educ. © 2015 American Association of Anatomists.
Mother-child joint writing in Chinese kindergarteners: metalinguistic awareness, maternal mediation and literacy acquisition

Tel Aviv University, IsraelThe present study examined the relations of Chinese word reading and writing to bothmaternal mediation of writing and a number of metalinguistic and cognitive skills in63 Hong Kong Chinese kindergarteners. The whole process of maternal mediation ofwriting, in which mothers individually facilitated their children’s writing of 12 two-character words in their own ways, was videotaped. This study replicated andextended previous work on the cognitive strategies mothers use to help children inwriting Chinese words. Mothers’ typical mediation strategies were positively andsigniﬁcantly associated with both children’s independent word reading and writing. Inaddition, maternal mediation of writing was uniquely associated with Chinese wordreading, but not word writing, even with metalinguistic and cognitive skills, includingphonological awareness, morphological awareness, orthographic processing andvisual knowledge, statistically controlled. Findings underscore the importance ofmothers’ early scaffolding in facilitating children’s literacy acquisition.
Testing Accommodations Research and Decision Making: The Case of “Good” Scores Being Highly Valued but Difficult to Achieve for All Students

The authors review both (a) definitional and legal issues associated with testing accommodations and (b) validity issues that confront educators who must make decisions about the use and likely effects of testing accommodations, and they summarize the results of 4 experimental studies they have conducted that examine the statistical effects of accommodations on test scores of students with and without disabilities.
Active Learning with Jeopardy: Students Ask the Questions———

Nontraditional instructional methods facilitate active learning by students. The Jeopardy exercise outlined in this article is based on the popular television game show and is presented as an active learning technique designed to (a) motivate students to actively participate in class and assume more responsibility for learning, (b) provide an in-class opportunity for teamwork, (c) reinforce students’learning of course concepts previously taught, and (d) add variety to classes by providing a fun environment for instructor and students alike. This article suggests using Jeopardy to review for exams. It concludes with a discussion of the effectiveness of the Jeopardy technique.
Heterotypic FcγR Clusters Evoke a Synergistic Ca2+ Response in Human Neutrophils (*)

Both Fcγ receptors on human neutrophils (FcγRIIa and FcγRIIIb) are capable of initiating signal transduction after multivalent cross-linking. However, immune complexes most likely activate neutrophils by a combined homotypic and heterotypic cross-linking of FcγRs. We have investigated the effect of homotypic and heterotypic FcγR cluster formation on changes in the intracellular free Ca2+ concentration. Combined heterotypic and homotypic cluster formation resulted in a Ca2+ response that was strongly enhanced as compared to the sum of both individual FcγR responses. This synergistic response was caused by the formation of heterotypic clusters of FcγRs and not by the simultaneous formation of homotypic clusters. This conclusion was supported by experiments with a bispecific antibody binding to both FcγRIIa and FcγRIIIb. The heterotypic FcγR cross-linking results in efficient activation of Ca2+ influx, probably caused by a more pronounced depletion of intracellular Ca2+ stores. Stimulation with immune complexes also induced Ca2+ influx in normal neutrophils, but not in FcγRIIIb-deficient neutrophils. The synergism between both FcγRs was also apparent in other responses of neutrophils, such as the activation of the respiratory burst. This study shows that the two different FcγRs on neutrophils complement each other in mediating an important cellular response.
Contextual conditioning in variable lexical phonology

ABSTRACT The variable lexical phonology proposed in Guy (1991) predicts an exponential relationship among rates of retention in word classes of different derivational histories. A class of words that satisfies the structural description of a variable rule at an early lexical level of derivation will undergo multiple operations of the rule and, therefore, exponentially reduced rates of retention, compared to a class of forms that only satisfies the structural description of the rule at the end of the derivation and thus is subject to its operation only once. For the case of English -t,d deletion, it is postulated that monomorphemic words (e.g., mist) are exposed to the deletion rule three times in a derivation, whereas semiweak past tense forms (e.g., left) are exposed twice, and regular past tense forms (e.g., missed) undergo the rule but once. The present article explores the consequences of this model for other variable constraints on a rule, such as the preceding and following segment constraints on -t,d deletion. Word-internal constraints, because they are present throughout the derivation, are shown to have quantitatively different patterns than external constraints, as the latter affect the rule only in its final, post-lexical operation. Four specific quantitative predictions are derived from the model to elucidate this distinction between internal and external constraints, and empirical data are presented to confirm the predictions.
Life estimation for long rod composite insulators subjected to accelerating ageing by combined static and cyclic loading

Influence of the position of fatigue characteristics on the cyclic load L versus time t plots on the long-term mechanical strength has been analyzed for long rod composite insulators, on the basis of experimental data. A procedure has been presented for forecasting mechanical durability of composite insulators from determined fatigue characteristics, for any given maximum cyclic loads and load amplitudes. It has been shown that long rod composite insulators of good manufacturing quality maintain their electric properties practically until their failure during the fatigue test.
Transcriptome Analysis and Identification of Differentially Expressed Transcripts of Immune-Related Genes in Spleen of Gosling and Adult Goose

The goose (Anser cygnoides), having high nutritional value, high-quality feathers and high economic benefit, is an economically important poultry species. However, the molecular mechanisms underlying the higher susceptibility to pathogens in goslings than in adult geese remains poorly understood. In this study, the histological sections of spleen tissue from a two-week-old gosling and an adult goose, respectively, were subjected to comparative analysis. The spleen of gosling was mainly composed of mesenchyma, accompanied by scattered lymphocytes, whereas the spleen parenchyma was well developed in the adult goose. To investigate goose immune-related genes, we performed deep transcriptome and gene expression analyses of the spleen samples using paired-end sequencing technology (Illumina). In total, 50,390 unigenes were assembled using Trinity software and TGICL software. Moreover, these assembled unigenes were annotated with gene descriptions and gene ontology (GO) analysis was performed. Through Kyoto encyclopedia of genes and genomes (KEGG) analysis, we investigated 558 important immune-relevant unigenes and 23 predicted cytokines. In addition, 22 immune-related genes with differential expression between gosling and adult goose were identified, among which the three genes showing largest differences in expression were immunoglobulin alpha heavy chain (IgH), mannan-binding lectin serine protease 1 isoform X1 (MASP1) and C–X–C chemokine receptor type 4 (CXCR4). Finally, of these 22 differentially expressed immune-related genes, seven genes, including tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), C-C motif chemokine 4-like (CCL4), CXCR4, interleukin 2 receptor alpha (IL2RA), MHC class I heavy chain (MHCIα), transporter of antigen processing 2 (TAP2) IgH, were confirmed by quantitative real-time PCR (qRT-PCR). The expression levels of all the candidate unigenes were up-regulated in adult geese other than that of TNFRSF13B. The comparative analysis of the spleen transcriptomes of gosling and adult goose may promote better understanding of immune molecular development in goose.
Identification of a differentiation-inducible promoter in the E7 open reading frame of human papillomavirus type 16 (HPV-16) in raft cultures of a new cell line containing high copy numbers of episomal HPV-16 DNA

Gene expression of human papillomaviruses (HPV) is tightly linked to differentiation processes within the pluristratified epithelium. To analyze changes in the transcription pattern of HPV-16 during epithelial cell differentiation, we established a permanently growing HPV-16 positive cell line, designated KG, from a vulvar intraepithelial neoplasm. KG cells of early passages harbored multiple copies of the HPV-16 DNA as episomes and were able to form a stratified epithelium in an organotypic raft culture system. Analysis of viral gene expression revealed the known transcription pattern of the early region of HPV-16 with the exception of a so far undefined mRNA class with start sites in the E7 open reading frame. Quantitative analysis of primer extension experiments with RNA from KG cells grown in monolayer and raft culture showed a strong induction of this transcript in differentiated KG cells, whereas the level of the mRNAs initiated at the early promoter P97 remained almost constant. Primer extension analyses with four different primers and direct sequencing of the extension product revealed that the differentiation-inducible transcript initiated at a novel promoter with a major start site around nucleotide position 670 (P670) in the E7 open reading frame of HPV-16. Sequence analysis of cDNAs derived from RNA of KG cells grown in raft culture suggested that the transcripts initiated at P670 have a coding potential for an E1E4 fusion protein and for the E5 protein.
Learning to hear voices: Listening to users of mental health services

This article reports findings from a User's Councils project developed as part of a multi-dimensional approach to the development of user-led community care services: the Birmingham Community Care Special Action Project (CCSAP). The evaluation of the user involvement dimension of CCSAP sought to answer three basic questions: Who was involved? How were they involved? What were the outcomes of involvement? This article highlights the particular significance of enabling users of mental health services to express a ‘voice’ which is recognized as valid by those professionally involved with their care. It identifies the different motivations and purposes which encourage users to become involved in user councils and emphasises the need for clarity and openness about the objectives to be achieved. It considers provider responses to those voices and discusses the importance of establishing means through which voice can be translated into action by those with responsibilities for services.
Does Environmental Print Identification Lead Children into Word Reading?

The question under study was whether context-free word reading skill evolves out of extensive experience with environmental print. Selected for the study were preschoolers aged three to five years who could identify at least 8 out of 10 samples of environmental print, such as a McDonald's sign in a photograph of the restaurant, and hence were environmental print “experts. ” Their ability to read various types of print samples was examined. They were shown signs and labels printed either with full context cues or only with logos or without any context cues or logos. These stimuli were printed with and without color cues. Also, letters in the print were altered to assess subjects' awareness of specific graphic cues in the labels and signs (e.g., OcDonald's for McDonald's). Results revealed that subjects' ability to read print declined somewhat when full contexts were removed and only logos remained. Performance dropped dramatically when logos were removed and only stylized print remained. Color cues made no contribution to identification. Letter alterations were not detected, even when subjects were prompted to look for errors. Assessment of word reading ability revealed not a continuous distribution of scores but rather a bimodal distribution indicating two distinct groups of subjects: 96 who could read few if any words, and 6 who could read most of the words. The pattern of failure on the print samples characterized only the prereaders. The readers identified print correctly regardless of context, and they detected letter errors easily. Since most subjects exhibited little awareness of graphic cues and little word reading skill, it is concluded that environmental print experience does not by itself lead subjects into word reading.
Childhood intussusception in Ile-ife: What has changed?

Background: Intussusception is one of the most common causes of intestinal obstruction in children. While the outcome has improved in the developed nations, the same cannot be said of the developing countries, more especially in the sub-Saharan region. This study aims to review our current experience in the management of childhood intussusception and factors affecting surgical outcome at the Obafemi Awolowo University Teaching Hospitals Complex Ile-Ife. Patients and Methods: This was a retrospective study of 78 patients treated for intussusception at paediatric surgical unit of Obafemi Awolowo University Teaching Hospitals Complex Ile-Ife between January 1993 and December 2011. The case notes of the patients were retrieved and the following information was recorded: Demographic characteristics, month of occurrence, clinical presentation, investigations, and management as well as the post-operative outcome. The patients were divided into two groups in terms of outcome. Results: There were 58 males and 20 females (M:F = 2.9-1). The age of most of the patients was between 3 months and 9 months with peak incidence at 6 months. Most patients 46 (58.9%) were seen during the dry season of December to April. Only six patients (7.7%) presented within 24 hours of onset of illness. More than half of the patients presented after 24 hours. Passage of red currant stool, vomiting, abdominal pain, fever, and abdominal distension, passage of watery stool, anal protrusion and palpable abdominal mass in various combinations were the clinical features. All the patients had surgical operations. The most common type of intussusception was ileo-colic type in 64 patients (82.1%). Intestinal resection rate was 41%. The overall mortality rate was 15.4%. Conclusion: There was a delay in presentation of children with intussusception with high post-operative mortality.
Bone Marrow Transplantation Restores Follicular Maturation and Steroid Hormones Production in a Mouse Model for Primary Ovarian Failure

Recent studies suggest that bone marrow stem cells (BMSCs) are promising grafts to treat a variety of diseases, including reproductive dysfunction. Primary ovarian failure is characterized by amenorrhea and infertility in a normal karyotype female, with an elevated serum level of follicle-stimulating hormone (FSH) and a decrease level of estrogen caused by a mutation in FSH receptor (FSHR) gene. Currently, there is no effective treatment for this condition. The phenotype of FSHR (−/−) mouse, FORKO (follitropin receptor knockout), is a suitable model to study ovarian failure in humans. Female FORKO mice have elevated FSH, decreased estrogen levels, are sterile because of the absence of folliculogenesis, and display thin uteri and small nonfunctional ovaries. In this study, we determined the effects of BMSC transplantation on reproductive physiology in this animal model. Twenty four hours post BMSC transplantation, treated animals showed detectable estroidogeneic changes in daily vaginal smear. Significant increase in total body weight and reproductive organs was observed in treated animals. Hemotoxylin and eosin (H&E) evaluation of the ovaries demonstrated significant increase in both the maturation and the total number of the follicles in treated animals. The FSH dropped to 40–50% and estrogen increased 4–5.5 times in the serum of treated animals compared to controls. The FSHR mRNA was detected in the ovaries of treated animals. Our results show that intravenously injected BMSCs were able to reach the ovaries of FORKO mice, differentiate and express FHSR gene, make FSHR responsive to FSH, resume estrogen hormone production, and restore folliculogenesis.
Pricing Policies And Control of Tobacco in Europe (PPACTE) project: cross-national comparison of smoking prevalence in 18 European countries

Limited data on smoking prevalence allowing valid between-country comparison are available in Europe. The aim of this study is to provide data on smoking prevalence and its determinants in 18 European countries. In 2010, within the Pricing Policies And Control of Tobacco in Europe (PPACTE) project, we conducted a face-to-face survey on smoking in 18 European countries (Albania, Austria, Bulgaria, Czech Republic, Croatia, England, Finland, France, Greece, Hungary, Ireland, Italy, Latvia, Poland, Portugal, Romania, Spain and Sweden) on a total of 18 056 participants, representative for each country of the population aged 15 years or older. Overall, 27.2% of the participants were current smokers (30.6% of men and 24.1% of women). Smoking prevalence was highest in Bulgaria (40.9%) and Greece (38.9%) and lowest in Italy (22.0%) and Sweden (16.3%). Smoking prevalence ranged between 15.7% (Sweden) and 44.3% (Bulgaria) for men and between 11.6% (Albania) and 38.1% (Ireland) for women. Multivariate analysis showed a significant inverse trend between smoking prevalence and the level of education in both sexes. Male-to-female smoking prevalence ratios ranged from 0.85 in Spain to 3.47 in Albania and current-to-ex prevalence ratios ranged from 0.68 in Sweden to 4.28 in Albania. There are considerable differences across Europe in smoking prevalence, and male-to-female and current-to-ex smoking prevalence ratios. Eastern European countries, lower income countries and those with less advanced tobacco control policies have less favourable smoking patterns and are at an earlier stage of the tobacco epidemic.