Miracle-dz/UniFAR-FTUs huggingface dataset:
Global metabolomic profiling targeting childhood obesity in the Hispanic population.

BACKGROUND Metabolomics may unravel important biological pathways involved in the pathophysiology of childhood obesity. OBJECTIVES We aimed to 1) identify metabolites that differ significantly between nonobese and obese Hispanic children; 2) collapse metabolites into principal components (PCs) associated with obesity and metabolic risk, specifically hyperinsulinemia, hypertriglyceridemia, hyperleptinemia, and hyperuricemia; and 3) identify metabolites associated with energy expenditure and fat oxidation. DESIGN This trial was a cross-sectional observational study of metabolomics by using gas chromatography-mass spectrometry and ultrahigh-performance liquid chromatography-tandem mass spectrometry analyses performed on fasting plasma samples from 353 nonobese and 450 obese Hispanic children. RESULTS Branched-chained amino acids (BCAAs) (Leu, Ile, and Val) and their catabolites, propionylcarnitine and butyrylcarnitine, were significantly elevated in obese children. Strikingly lower lysolipids and dicarboxylated fatty acids were seen in obese children. Steroid derivatives were markedly higher in obese children as were markers of inflammation and oxidative stress. PC6 (BCAAs and aromatic AAs) and PC10 (asparagine, glycine, and serine) made the largest contributions to body mass index, and PC10 and PC12 (acylcarnitines) made the largest contributions to adiposity. Metabolic risk factors and total energy expenditure were associated with PC6, PC9 (AA and tricarboxylic acid cycle metabolites), and PC10. Fat oxidation was inversely related to PC8 (lysolipids) and positively related to PC16 (acylcarnitines). CONCLUSIONS Global metabolomic profiling in nonobese and obese children replicates the increased BCAA and acylcarnitine catabolism and changes in nucleotides, lysolipids, and inflammation markers seen in obese adults; however, a strong signature of reduced fatty acid catabolism and increased steroid derivatives may be unique to obese children. Metabolic flexibility in fuel use observed in obese children may occur through the activation of alternative intermediary pathways. Insulin resistance, hyperleptinemia, hypertriglyceridemia, hyperuricemia, and oxidative stress and inflammation evident in obese children are associated with distinct metabolomic profiles.
Perceptions of source efficacy and persuasion: Multiple mechanisms for source effects on attitudes

When communicators are perceived as likely to bring proposed outcomes to fruition, they have source efficacy. Although perceptions of source efficacy are common in persuasion settings, this construct has received little direct research attention. The present research explored how source efficacy may impact persuasion in different ways at different levels of motivation to process messages. Across three experiments, participants encountered message arguments of varying quality from a source manipulated to be relatively efficacious or inefficacious. When motivation to process the message was low, source efficacy served as a peripheral cue (Experiment 1). When motivation was high, efficacy information learned before the message biased processing of ambiguous messages (Experiment 2), but source efficacy learned after the message affected the amount of confidence people had in their message-related thoughts (Experiment 3). These effects of source efficacy were distinct from effects of perceived source expertise/credibility. Copyright # 2011 John Wiley & Sons, Ltd.
A survey of naming and routing in information-centric networks

The concept of information-centric networking (ICN) defines a new communication model that focuses on what is being exchanged rather than which network entities are exchanging information. From the ICN perspective, contents are first class network citizens instead of hosts. ICN's primary objective is to shift the current host-oriented communication model toward a content-centric model for effective distribution of content over the network. In recent years this paradigm shift has generated much interest in the research community and sprung several research projects around the globe to investigate and advance this stream of thought. Content naming and content-based routing are core research challenges in this research community. In this survey, we analyze, compare, and contrast the naming and routing mechanisms proposed by some of the most prominent ICN research projects.
Prony systems via decimation and homotopy continuation

We consider polynomial systems of Prony type, appearing in many areas of mathematics. Their robust numerical solution is considered to be difficult, especially in "near-colliding" situations. We transform the nonlinear part of the Prony system into a Hankel-type polynomial system. Combining this representation with a recently discovered "decimation" technique, we present an algorithm which applies homotopy continuation on a sequence of modified Hankel-type systems as above. In this way, we are able to solve for the nonlinear variables of the original system with high accuracy when the data is perturbed.
Interest rate fluctuations and equilibrium in the housing market

Abstract I study the general equilibrium of the housing market in an economy populated by overlapping generations of households. A contribution of the present paper is to solve for the housing market equilibrium in the presence of aggregate (interest rate) uncertainty with a realistic mortgage contract. In addition, households also face idiosyncratic uncertainty resulting from stochastic changes over the lifecycle in tastes (or needs) for housing. In this environment, profit-maximizing banks offer fixed-rate mortgage (FRM) contracts to homebuyers. As seems plausible, each housing market transaction is subject to a fixed cost, which gives rise to S-s policy rules for housing transactions: existing homeowners change the size of their houses only if there is a sufficiently large change in the state of the economy (i.e., in interest rates, in their taste for housing, etc.). A plausibly calibrated version of the model is consistent with three empirically documented features of the housing market: (i) highly volatile housing prices and transaction volume, (ii) a strong positive correlation between transaction volume and housing prices, and (iii) a significant negative relationship between interest rates and housing prices, which can rationalize a large part of the recent boom in housing prices in the US and around the world.
The Organizational Ecology of a Technological System.

An abbreviated, early version of this paper received the 1988 Lou Pondy Award for the best paper based on a dissertation from the Organization and Management Theory Division of the Academy of Management. This research was supported, in part, by the AT&T Fellowship in Telephone History and by a grant from the Chancellor's Patent Fund of the University of California, Berkeley. I thank Glenn Carroll for advising me in this research and many others for their suggestions: Terry Amburgey, Joan Booth, Jacques Delacroix, Claude Fischer, John Freeman, Michael Hannan, Anne Miner, Will Mitchell, Richard Nelson, Charles O'Reilly, Jitendra Singh, Anand Swaminathan, Michael Tushman, and Jim Wade. Thanks to Gerry Barrett of the Telephony Publishing Company and to Robert Lewis, Robert Garnet, and Mildred Ettlinger of the AT&T Historical Archives for assistance in data collection. This paper investigates organizational mortality in the early American telephone industry, in which thousands of companies proliferated and failed under conditions of technological change. Drawing on the theory of community ecology, it is predicted that when technologies are systemic, technological change does not necessarily favor advanced organizations. Instead, mutualism is predicted among both advanced and primitive firms, as long as they are technologically standardized and differentiated. Competition is expected when organizations are technologically incompatible or noncomplementary. The hypotheses are supported by dynamic models of organizational mortality, estimated using archival data describing the life histories of all telephone companies that operated in Pennsylvania up to 1934 and in southeast Iowa from 1900 to 1930. -
9 Creativity in Organizations

Abstract In this chapter, I review contemporary theories and research on creativity in organizations. After discussing key definitional issues in this domain, I review the contemporary scholarly literature proceeding from the most molecular of perspectives focusing on within-individual processes to the more molar perspective of the collective creativity that can take place in work groups. While the within-individual process featured most prominently in the extant literature is intrinsic motivation, after a treatment of some fundamental issues surrounding the intrinsic motivation construct, I review research on conscious and unconscious thinking and positive and negative affect as key internal processes relevant to understanding creativity. Next, I focus on contextual influences on creativity including safety signals, creativity prompts, supervisors, leadership, and networks. Lastly, I focus on creativity in groups (from both an input and a process perspective). In closing, I reiterate a recurrent theme th.
Screening for mutations of the APC gene in 66 Italian familial adenomatous polyposis patients: Evidence for phenotypic differences in cases with and without identified mutation

Germline mutations in the APC gene are responsible for familial adenomatous polyposis (FAP), a dominantly inherited syndrome characterized by the development of hundreds to thousands of polyps in the colon and in the rectum of affected individuals and by variable extracolonic manifestations (gastric and duodenal polyps, osteomas, retinal lesions, and desmoid tumors). Through the combined use of single‐strand conformation polymorphism (SSCP) analysis and the protein truncation test (PTT), we have screened 66 Italian FAP patients and found 29 different APC mutations in a total of 34 cases. Of the identified mutations, 15 were nonsense, 12 were 1‐ to 5‐bp deletions or insertions and two were complex rearrangements, all leading to the formation of premature stop codons. Only 10 mutations had been already previously described at the germline level, confirming the high heterogeneity of the APC mutational spectrum. The mean age of diagnosis in mutation positive cases and their affected relatives was significantly lower than in cases without identified mutation (30.6 vs 39.1 years, respectively; p = 0.003). In addition, among patients without a family history of polyposis, all mutation‐positive cases displayed at least one of the extracolonic manifestations usually associated with FAP, whereas in one‐half of the cases without identified mutation, none of these phenotypes was observed. Although a fraction of apparently mutation‐negative cases were likely to be due to limitations of the mutation screening strategy, our results suggest, in agreement with previous reports, that allelic and/or genetic heterogeneity might be responsible for the phenotypic variability observed in FAP patients. Hum Mutat 13:116–123, 1999. © 1999 Wiley‐Liss, Inc.
Hierarchical confirmatory factor analysis of the Flow State Scale in an exercise setting

1 In this study, we examined the factor structure and internal consistency of the Flow 2 State Scale using responses of exercise participants. This self-report questionnaire 3 consists of nine subscales designed to assess flow in sport and physical activity 4 settings. It was administered to 1, 231 aerobic dance exercise participants. 5 Confirmatory factor analyses (CFA) were used to test three competing measurement 6 models of the flow construct: a single-factor model, a nine factor model, and a 7 hierarchical model positing a higher-order flow factor to explain the intercorrelations 8 between the nine first-order factors. The single-factor model showed a poor fit to the 9 data. The nine-factor model and the hierarchical model did not show an adequate fit to 10 the data. All FSS subscales displayed acceptable internal consistency indices (a > .70) 11 with the exception of transformation of time (a = .65). Collectively, the present results 12 did not provide support for the tenability of the singlefactor, nine-factor or 13 hierarchical FSS measurement models in an exercise setting. 14
Conformally exact metric and dilaton in string theory on curved spacetime.

Using a Hamiltonian approach to gauged WZW models, we present a general method for computing the conformally exact metric and dilaton, to all orders in the $1/k$ expansion, for any bosonic, heterotic, or type-II superstring model based on a coset $G/H$. We prove the following relations: (i) For type-II superstrings the conformally exact metric and dilaton are identical to those of the non-supersymmetric {\it semi-classical} bosonic model except for an overall renormalization of the metric obtained by $k\to k- g$. (ii) The exact expressions for the heterotic superstring are derived from their exact bosonic string counterparts by shifting the central extension $k\to 2k-h$ (but an overall factor $(k-g)$ remains unshifted). (iii) The combination $e^\Phi\sqrt{-G}$ is independent of $k$ and therefore can be computed in lowest order perturbation theory as required by the correct formulation of a conformally invariant path integral measure. The general formalism is applied to the coset models $SO(d-1,2)_{-k}/SO(d-1,1)_{-k}$ that are relevant for string theory on curved spacetime. Explicit expressions for the conformally exact metric and dilaton for the cases $d=2,3,4$ are given. In the semiclassical limit $(k\to \infty)$ our results agree with those obtained with the Lagrangian method up to 1-loop in perturbation theory.
Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells

Intercellular transfer of organelles via tunneling nanotubes (TNTs) is a novel means of cell-to-cell communication. Here we demonstrate the existence of TNTs between co-cultured RT4 and T24 bladder cancer cells using light microscopy, fluorescence imaging, and scanning electron microscopy (SEM). Spontaneous unidirectional transfer of mitochondria from T24 to RT4 cells was detected using fluorescence imaging and flow cytometry. The distribution of mitochondria migrated from T24 cells was in good agreement with the original mitochondria in RT4 cells, which may imply mitochondrial fusion. We detected cytoskeleton reconstruction in RT4-Mito-T24 cells by observing F-actin redistribution. Akt, mTOR, and their downstream mediators were activated and increased. The resultant increase in the invasiveness of bladder cancer cells was detected in vitro and in vivo. These data indicate that TNTs promote intercellular mitochondrial transfer between heterogeneous cells, followed by an increase in the invasiveness of bladder cancer cells.
ADC measurement of abdominal organs and lesions using parallel imaging technique.

OBJECTIVE The purpose of our study was to assess the reliability and usefulness of parallel imaging for apparent diffusion coefficient (ADC) measurement of abdominal organs and lesions. MATERIALS AND METHODS Single-shot spin-echo echo-planar diffusion-weighted MRI (TE = 66, b = 0, 600 s/mm2) was performed in phantom and clinical studies. The b value was set to minimize the effects of perfusion in tissue and to maintain signal-to-noise ratio. Bottle phantoms were scanned with and without parallel imaging and with various parallel imaging factors and at various positions to evaluate the effects of parallel imaging on ADCs. In 200 consecutive clinical patients (122 men and 78 women: mean age, 61.9 years), ADCs were calculated for liver (four segments), spleen, pancreas (head, body, tail), gallbladder, renal parenchyma, and back muscle, and then compared to evaluate the reliability of clinical ADC measurements with parallel imaging. ADCs were also calculated for diffuse diseases and focal lesions (94 malignant and 93 benign) of abdominal organs to evaluate the clinical usefulness of ADC. RESULTS Location-dependent changes in water ADCs were minimal with parallel imaging factors first of 3, then of 4, and were small except for measurements at the image periphery. Acetone ADCs were saturated at 4.00 x 10(-3) mm2/s. Degraded image quality prevented ADC measurement of the left hepatic lobe and pancreas in 7-18 patients. There was no significant difference among ADCs of four liver segments (1.50 +/- 0.24 [SD] x 10(-3) mm2/s - 1.56 +/- 0.31 x 10(-3) mm2/s) and between ADCs of the right and left kidneys (2.65 +/- 0.30 x 10(-3) mm2/s, 2.59 +/- 0.33 x 10(-3) mm2/s). ADC of the pancreas tail (1.65 +/- 0.37 x 10(-3) mm2/s) was significantly lower than those of the head (1.81 +/- 0.40 x 10(-3) mm2/s) and body (1.81 +/- 0.41 x 10(-3) mm2/s) (p < 0.005). Renal ADCs were significantly lower in patients with renal failure (right: 2.15 +/- 0.30 x 10(-3) mm2/s; left: 2.11 +/- 0.25 x 10(-3) mm2/s) than in those without disease (right: 2.67 +/- 0.29 x 10(-3) mm2/s; left: 2.60 +/- 0.32 x 10(-3) mm2/s) (p < 0.005). ADC of pancreatic cancer was significantly higher than that of healthy pancreas (p < 0.05). ADC of renal angiomyolipoma was significantly lower than those of renal cell carcinoma and healthy renal parenchyma (p < 0.0005). CONCLUSION Clinical ADC measurements of abdominal organs and lesions using parallel imaging appear to be reliable and useful, and the effect of parallel imaging on calculated values is considered to be minimal.
Deviant Homicide: A New Look at the Role of Motives and Victim-Offender Relationships

Like all crimes, homicide has a normative character. That is, homicide is characterized by a certain level of social organization that creates routine expectations about the “appropriate” combination of motives and victim offender relationships, as well as situational characteristics. Previous homicide research has found that stranger violence most often has an instrumental motive, whereas homicides within primary relationships are expressive in nature. Using data from homicide events in St. Louis, nonnormative or deviant homicides are examined. These events are of particular relevance to understanding homicide and public reactions to homicide.
The Infotainment Quotient in Routine Television News: A Director's Perspective

To what extent does routine television news supply citizens with essential political information? To what extent are routine stories sensationalized so that their informational content is diluted or obscured? How do television news directors frame routine news stories and rationalize the mix of factual reporting and dramatization that they present? To answer these questions, television news producers were presented with hypothetical routine news events and asked to construct news presentations and explain their framing rationales. The content of actual routine news stories was also analyzed for comparisons with the hypothetical accounts. The data indicate that both actual and hypothetical routine television news stories are designed and executed to answer the who, what, where and when questions that provide essential information to citizens. But they slight the why and how questions that would assist viewers in placing the facts into a more meaningful perspective. Framing is deliberately dramatic so that the policy-relevant aspects of news are often overshadowed by entertainment features.
Early entry of plasma proteins into damaged neurons in brain infarcts

Entry of plasma proteins into damaged neurons has previously been demonstrated in various pathological conditions, but little is known about brain infarcts in this respect. In the present study, focal ischemic lesions were produced in rats by permanent occlusion of the middle cerebral artery (MCA). The animals were killed from 1 to 48 h postlesion. Leakage of plasma proteins across the blood‐brain barrier into the infarcted area was visualized with immunostaining 2–3 h after the occlusion. This is earlier than in most previous reports. Entry of plasma proteins into ischemic neurons was seen 3 h after permanent occlusion of the MCA, while reliable changes were not seen until 12–24 h in sections stained with hematoxylin and eosin (H & E). Ischemic neurons stained for plasma proteins irrespective of their morphological appearance. Even cells that appeared normal with H & E staining were positively labeled. The technique may be used to diagnose very early ischemic lesions.
Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis.

AIM To investigate the usefulness of endoscopic ultra-sound-guided fine needle aspiration (EUS-FNA) in the differentiation of autoimmune pancreatitis (AIP). METHODS We retrospectively reviewed 47 of 56 AIP patients who underwent EUS-FNA and met the Asian diagnostic criteria. On 47 EUS-FNA specimens, we evaluated the presence of adequate material and characteristic features of lymphoplasmacytic sclerosing pancreatitis (LPSP) and idiopathic duct-centric pancreatitis (IDCP) mentioned in the International Consensus Diagnostic Criteria and examined if these findings make a contribution to the differential diagnosis of type 1 and type 2 AIP. A disposable 22-gauge needle was used for EUS-FNA. RESULTS Adequate specimens including pancreatic tissue for differentiating AIP from cancer were obtained from 43 of 47 patients who underwent EUS-FNA. EUS-FNA was performed from the pancreatic head in 21 cases, which is known to be technically difficult when performed by core biopsy; there was no significant difference in the results compared with pancreatic body-tail. Nine of 47 patients met level 1 findings of LPSP and 5 patients met level 2 findings of LPSP. No one met level 1 findings of IDCP, but 3 patients met level 2 findings of IDCP. Of 10 seronegative cases, 2 cases were diagnosed with "definitive type 1 AIP", and 3 cases were diagnosed with "probable type 2 AIP" when considering both the level 2 histological findings and response to steroids. CONCLUSION EUS-FNA is useful in the differentiation of type 1 and type 2 AIP, particularly in seronegative cases.
The Effect of Political Disagreement on Discretion

Delegation models make contrasting assumptions about how political disagreement affects discretion and empirical research reports contradictory findings. The authors aim to shed new light on this puzzle by distinguishing the mechanisms that drive the effect of political disagreement on discretion. Four conditions influence the strength of each mechanism: (a) policy salience, (b) actors involved, (c) their capacity, and (d) decision rule. They explore this theoretical framework on the case of economic restructuring in the United Kingdom and show that political disagreement reduces discretion. There is no significant interaction effect between salience and political disagreement on discretion.
Gilding the Outcome by Tarnishing the Past

We tested for inflationary bias introduced through retrospective pretests by analyzing traditional pretest, retrospective pretest, and posttest evaluation data collected on a first-line supervisory leadership training program, involving 196 supervisors and their subordinates, across 17 organizational settings. Retrospective pretest ratings by both trained (supervisors) and untrained (subordinates) respondents were significantly lower than traditional pretest ratings, resulting in substantially inflated training effect sizes when posttests were compared with retrospective pretests rather than with traditional pretests. Further analysis revealed evidence of both respondents' application of an implicit theory of change (i.e., assumption that posttraining scores should generally be higher than pretraining scores) and a tendency to rate their own improvement as greater than that of others. Implications for program evaluation are discussed.