Miracle-dz/UniFAR-FTUs huggingface dataset:
Patch-wise low-dimensional probabilistic linear discriminant analysis for Face Recognition

The paper introduces a novel approach to face recognition based on the recently proposed low-dimensional probabilistic linear discriminant analysis (LD-PLDA). The proposed approach is specifically designed for complex recognition tasks, where highly nonlinear face variations are typically encountered. Such data variations are commonly induced by changes in the external illumination conditions, viewpoint changes or expression variations and represent quite a challenge even for state-of-the-art techniques, such as LD-PLDA. To overcome this problem, we propose here a patch-wise form of the LDPLDA technique (i.e., PLD-PLDA), which relies on local image patches rather than the entire image to make inferences about the identity of the input images. The basic idea here is to decompose the complex face recognition problem into simpler problems, for which the linear nature of the LD-PLDA technique may be better suited. By doing so, several similarity scores are derived from one facial image, which are combined at the final stage using a simple sum-rule fusion scheme to arrive at a single score that can be employed for identity inference. We evaluate the proposed technique on experiment 4 of the Face Recognition Grand Challenge (FRGCv2) database with highly promising results.
Genetic mapping and characterization of the bleeding disorder in the fawn-hooded hypertensive rat

Summary Release of platelet dense granule contents occurs in response to vascular injury, playing an important role in platelet aggregation and primary hemostasis. Abnormalities of the platelet dense granules results in a bleeding disorder of variable severity termed “storage pool defect” (SPD). We have examined the fawn-hooded hypertensive (FHH) rat as a model of SPD in order to genetically map the locus (Bd) responsible for prolonged bleeding. Platelet function assays of the FHH rat confirmed the presence of a platelet dense granule SPD. However electron microscopy and lysosomal enzyme assays indicated differences between the FHH rat and other rodent models of SPD. Genetic mapping through the use of congenic FHH rats localized the Bd locus to an approximately 1 cM region on rat chromosome 1. Through the use of comparative mapping between species and analysis of the initial draft of the rat genome assembly, six known and thirty-four putative genes were identified in the Bd locus. None of these genes have been previously implicated in platelet function. Therefore positional cloning of the gene responsible for the bleeding disorder in the FHH rat will lead to new insights in platelet physiology, with implications for diagnosis and management of hemostatic and thrombotic disorders.
Resource Allocation in LTE-LAA and WiFi Coexistence: A Joint Contention Window Optimization Scheme

Licensed-assisted access (LAA) is a promising technology to meet the exponential increase of traffic demand by exploiting the 5GHz unlicensed spectrum. However, without proper coexistence schemes, the performance of WiFi in coexistence with LAA will be degraded significantly. Equipped with listen-before-talk (LBT) schemes, LAA applies a channel access mechanism similar to distributed coordination function (DCF) in WiFi, which is not optimal in terms of spectrum efficiency. In this paper, we propose an joint optimization scheme to find the optimal combination of WiFi and LAA contention windows (CWs) that maximizes LAA throughput, while guarantees WiFi throughput above a predefined threshold. The accuracy and efficiency of the proposed scheme is evaluated by comparing with the exhaustive search: almost the same combination of CWs are achieved with much lower complexity by using the proposed scheme than the exhaustive search. Numeric results show that the proposed adaptive scheme is more effective in dense scenario, where high system (up to 40%) and LAA throughput gain (up to 100%) are achieved. The trade-off between LAA (system) throughput and WiFi throughput is also revealed.
Early Treatment of Acute Pyelonephritis in Children Fails to Reduce Renal Scarring: Data From the Italian Renal Infection Study Trials

OBJECTIVES. The American Academy of Pediatrics recommendation for febrile infants and young children suspected of having a urinary tract infection is early antibiotic treatment, given parenterally if necessary. In support of this recommendation, data suggesting that delay in treatment of acute pyelonephritis increases the risk of kidney damage are cited. Because the risk was not well defined, we investigated renal scarring associated with delayed versus early treatment of acute pyelonephritis in children. METHODS. The research findings are derived from 2 multicenter, prospective, randomized, controlled studies, Italian Renal Infection Study 1 and 2, whose primary outcomes dealt with initial antibiotic treatment and subsequent prophylaxis, respectively. From the 2 studies, we selected the 287 children with confirmed pyelonephritis on acute technetium-99m-dimercaptosuccinic acid scans who underwent repeat scanning to detect scarring 12 months later. The children were 1 month to <7 years of age when they presented with their first recognized episode of acute pyelonephritis in northeast Italy. RESULTS. Progressive delay in antibiotic treatment of acute pyelonephritis from <1 to ≥5 days after the onset of fever was not associated with any significant increase in the risk of scarring on technetium-99m-dimercaptosuccinic acid scans obtained 1 year later. The risk of scarring remained relatively constant at 30.7 ± 7%. Clinical and laboratory indices of inflammation were comparable in all groups, as was the incidence of vesicoureteric reflux. CONCLUSIONS. Early treatment of acute pyelonephritis in infants and young children had no significant effect on the incidence of subsequent renal scarring. Furthermore, there was no significant difference in the rate of scarring after acute pyelonephritis when infants and young children were compared with older children.
Land use patterns and access in Mexico City

The problem of distribution of land uses in urban space in Latin American cities has been examined under different perspectives. Most authors tend to model patterns of population and land use as a consequence of social and economic processes alone, failing to address urban space as an intrinsic variable. Instead, the theory of cities as movement economies argues that land use patterns are influenced by movement flows, which are in turn strongly affected by the urban grid. As a result, land uses such as retail would seek highly accessible locations to take advantage of such flows while residential uses would avoid them. However, space syntax techniques traditionally used to point out this relationship do not seem to reveal it so easily in non-organic cities like Mexico. This paper addresses the relationship between patterns of accessibility and land use in the first ring of Mexico City as a spatial strategy. A new functional description of the city where plots are nodes connected to flows that represent the street network is adopted. This model enables us to measure accessibility at the level of plots. Following this, we focus on the occurrence of land use types in highly or low accessible locations using cumulative distribution functions. If the distribution of land uses was random, the proportion of land use types would be more or less uniform throughout the area. It is shown that the relationship between accessibility and land use is not linear and is guided by movement economy forces. It is suggested that the understanding of these relationship is key to plan for sustainable growth objectively.
Single-dose ketorolac and pethidine in acute postoperative pain: systematic review with meta-analysis.

For a systematic review of postoperative analgesic efficacy and adverse effects of single doses, injected or oral, of pethidine and ketorolac compared with placebo, we sought published randomized studies in moderate to severe postoperative pain. Information on summed pain intensity or pain relief outcomes over 4-6 h was extracted and converted to dichotomous information to produce the number of patients with at least 50% pain relief. This was used to calculate the relative benefit and number-needed-to-treat (NNT) for one patient to achieve at least 50% pain relief. Minor and major adverse effect data were extracted and summarized. For pethidine 100 mg i.m. , eight randomized, controlled studies met the inclusion criteria, with 203 patients given pethidine and 161 placebo. The NNT to produce at least 50% pain relief was 2.9 (95% confidence interval 2.3-3.9). At this dose, pethidine produced significantly more drowsiness and dizziness than placebo, with numbers-needed-to-harm (NNH) of 2.9 (2.2-4.4) and 7.2 (4.8-14), respectively. For ketorolac, 14 reports met the inclusion criteria (six i.m. and eight oral). Most i.m. information (176 patients) was available for the 30 mg dose, which had an NNT of 3.4 (2.5-4.9). Most oral information was available for the 10 mg dose, which had an NNT of 2.6 (2.3-3.1). Oral ketorolac 10 mg was consistently at least as effective as ketorolac 30 mg i.m. Only with oral ketorolac 10 mg were there significantly more adverse effects than with placebo, with an NNH for any adverse effect of 7.3 (4.7-17).
Gut Microbiota Mediate Insecticide Resistance in the Diamondback Moth, Plutella xylostella (L.)

The development of insecticide resistance in insect pests is a worldwide concern and elucidating the underlying mechanisms is critical for effective crop protection. Recent studies have indicated potential links between insect gut microbiota and insecticide resistance and these may apply to the diamondback moth, Plutella xylostella (L.), a globally and economically important pest of cruciferous crops. We isolated Enterococcus sp. (Firmicutes), Enterobacter sp. (Proteobacteria), and Serratia sp. (Proteobacteria) from the guts of P. xylostella and analyzed the effects on, and underlying mechanisms of insecticide resistance. Enterococcus sp. enhanced resistance to the widely used insecticide, chlorpyrifos, in P. xylostella, while in contrast, Serratia sp. decreased resistance and Enterobacter sp. and all strains of heat-killed bacteria had no effect. Importantly, the direct degradation of chlorpyrifos in vitro was consistent among the three strains of bacteria. We found that Enterococcus sp. , vitamin C, and acetylsalicylic acid enhanced insecticide resistance in P. xylostella and had similar effects on expression of P. xylostella antimicrobial peptides. Expression of cecropin was down-regulated by the two compounds, while gloverin was up-regulated. Bacteria that were not associated with insecticide resistance induced contrasting gene expression profiles to Enterococcus sp. and the compounds. Our studies confirmed that gut bacteria play an important role in P. xylostella insecticide resistance, but the main mechanism is not direct detoxification of insecticides by gut bacteria. We also suggest that the influence of gut bacteria on insecticide resistance may depend on effects on the immune system. Our work advances understanding of the evolution of insecticide resistance in this key pest and highlights directions for research into insecticide resistance in other insect pest species.
Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity

Human immunodeficiency virus type 1 (HIV-1) acquires several host cell membrane proteins when it buds from infected cells. To study the effect of virally incorporated host-derived ICAM-1 glycoproteins on the biology of HIV-1, we have developed a transient expression system that has enabled us to produce virus particles differing only in the absence or the presence of virion-bound ICAM-1. By using a single-round infection assay based on an ICAM-1-negative target T-cell line stably transfected with an HIV-1 long terminal repeat driven luciferase gene construct, we have been able to demonstrate that the acquisition of host-derived ICAM-1 by HIV-1 has functional significance, since it leads to a pronounced increase in viral infectivity (4.6- to 9.8-fold) in an ICAM-1/LFA-1-dependent fashion, as shown by blocking with anti-ICAM-1 and -LFA-1 antibodies. The same potentiating effect on viral infectivity was also observed with monocytoid cells. Studies of the kinetics of infection revealed that the positive effect mediated by virally embedded host cell membrane ICAM-1 is due to an increase in the efficiency of early steps in the viral life cycle. These results provide new insights into how incorporation of host proteins can modulate the biological properties of HIV-1. Our findings have direct clinical relevance, considering that ICAM-1 is expressed on the surface of virus-infected cells and, more importantly, that host-derived ICAM-1 has been shown to be acquired by clinical HIV-1 isolates grown on primary mononuclear cells. These data justify a more complete analysis of the other putative role(s) that virally incorporated ICAM-1 may play in the life cycle of HIV-1, for example, at the level of neutralization sensitivity.
Signals of Climate Change in Butterfly Communities in a Mediterranean Protected Area

The European protected-area network will cease to be efficient for biodiversity conservation, particularly in the Mediterranean region, if species are driven out of protected areas by climate warming. Yet, no empirical evidence of how climate change influences ecological communities in Mediterranean nature reserves really exists. Here, we examine long-term (1998–2011/2012) and short-term (2011–2012) changes in the butterfly fauna of Dadia National Park (Greece) by revisiting 21 and 18 transects in 2011 and 2012 respectively, that were initially surveyed in 1998. We evaluate the temperature trend for the study area for a 22-year-period (1990–2012) in which all three butterfly surveys are included. We also assess changes in community composition and species richness in butterfly communities using information on (a) species’ elevational distributions in Greece and (b) Community Temperature Index (calculated from the average temperature of species' geographical ranges in Europe, weighted by species' abundance per transect and year). Despite the protected status of Dadia NP and the subsequent stability of land use regimes, we found a marked change in butterfly community composition over a 13 year period, concomitant with an increase of annual average temperature of 0.95°C. Our analysis gave no evidence of significant year-to-year (2011–2012) variability in butterfly community composition, suggesting that the community composition change we recorded is likely the consequence of long-term environmental change, such as climate warming. We observe an increased abundance of low-elevation species whereas species mainly occurring at higher elevations in the region declined. The Community Temperature Index was found to increase in all habitats except agricultural areas. If equivalent changes occur in other protected areas and taxonomic groups across Mediterranean Europe, new conservation options and approaches for increasing species’ resilience may have to be devised.
Cell-Specific Vacuolar Calcium Storage Mediated by CAX1 Regulates Apoplastic Calcium Concentration, Gas Exchange, and Plant Productivity in Arabidopsis[W][OA]

Mineral elements are often preferentially stored in vacuoles of specific leaf cell types, but the mechanism and physiological role for this phenomenon is poorly understood. We use single-cell analysis to reveal the genetic basis underpinning mesophyll-specific calcium storage in Arabidopsis leaves and a variety of physiological assays to uncover its fundamental importance to plant productivity. The physiological role and mechanism of nutrient storage within vacuoles of specific cell types is poorly understood. Transcript profiles from Arabidopsis thaliana leaf cells differing in calcium concentration ([Ca], epidermis <10 mM versus mesophyll >60 mM) were compared using a microarray screen and single-cell quantitative PCR. Three tonoplast-localized Ca2+ transporters, CAX1 (Ca2+/H+-antiporter), ACA4, and ACA11 (Ca2+-ATPases), were identified as preferentially expressed in Ca-rich mesophyll. Analysis of respective loss-of-function mutants demonstrated that only a mutant that lacked expression of both CAX1 and CAX3, a gene ectopically expressed in leaves upon knockout of CAX1, had reduced mesophyll [Ca]. Reduced capacity for mesophyll Ca accumulation resulted in reduced cell wall extensibility, stomatal aperture, transpiration, CO2 assimilation, and leaf growth rate; increased transcript abundance of other Ca2+ transporter genes; altered expression of cell wall–modifying proteins, including members of the pectinmethylesterase, expansin, cellulose synthase, and polygalacturonase families; and higher pectin concentrations and thicker cell walls. We demonstrate that these phenotypes result from altered apoplastic free [Ca2+], which is threefold greater in cax1/cax3 than in wild-type plants. We establish CAX1 as a key regulator of apoplastic [Ca2+] through compartmentation into mesophyll vacuoles, a mechanism essential for optimal plant function and productivity.
Terminal Sliding Mode Control for Space Rendezvous and Docking

The relative motion control for spacecraft rendezvous and docking is considered. The relative position dynamics described in the target spacecraft's orbital frame, and attitude dynamics of the chaser spacecraft described in the chaser body frame are all formulated in Euler-Lagrange forms. Based on property analysis of the coupled dynamic model a terminalb sliding mode control law is designed for the chaser with modeling uncertainties and external disturbances by using the Lyapunov redesign method. It is proved that the close-loop tracking error convergences to zero in finite time. Numerical simulation demonstrates effectiveness of the proposed control law.
Calculation of pKa in proteins with the microenvironment modulated‐screened coulomb potential

The MM‐SCP has been applied to predict pKa values of titratable residues in wild type and mutants of staphylococcal nuclease (SNase). The calculations were based on crystal structures made available by the Garcia‐Moreno Laboratory. In the mutants, mostly deeply buried hydrophobic residues were replaced with ionizable residues, and thus their pKa values could be measured and calculated using various methods. The data set used here consisted of a set of WT SNase for which His pKa at several ionic strengths had been measured, a set of mutants for which measured pKa were available and a set of 11 mutants for which the measured pKa were not known at the time of calculation. For this latter set, blind predictions were submitted to the protein pKa cooperative, 2009 workshop at Telluride, where the results of the blind predictions were discussed (the RMSD of the submitted set was 1.10 pH units). The calculations on the structures with known pKa indicated that in addition to weaknesses of the method, structural issues were observed that led to larger errors (>1) in pKa predictions. For example, different crystallographic conditions or steric clashes can lead to differences in the local environment around the titratable residue, which can produce large differences in the calculated pKa. To gain further insight into the reliability of the MM‐SCP, pKa of an extended set of 54 proteins belonging to several structural classes were carried out. Here some initial results from this study are reported to help place the SNase results in the appropriate context. Proteins 2011. © 2011 Wiley‐Liss, Inc.
Republished error management: Descriptions of verbal communication errors between staff. An analysis of 84 root cause analysis-reports from Danish hospitals

Introduction Poor teamwork and communication between healthcare staff are correlated to patient safety incidents. However, the organisational factors responsible for these issues are unexplored. Root cause analyses (RCA) use human factors thinking to analyse the systems behind severe patient safety incidents. The objective of this study is to review RCA reports (RCAR) for characteristics of verbal communication errors between hospital staff in an organisational perspective. Method Two independent raters analysed 84 RCARs, conducted in six Danish hospitals between 2004 and 2006, for descriptions and characteristics of verbal communication errors such as handover errors and error during teamwork. Results Raters found description of verbal communication errors in 44 reports (52%). These included handover errors (35 (86%)), communication errors between different staff groups (19 (43%)), misunderstandings (13 (30%)), communication errors between junior and senior staff members (11 (25%)), hesitance in speaking up (10 (23%)) and communication errors during teamwork (8 (18%)). The kappa values were 0.44–0.78. Unproceduralized communication and information exchange via telephone, related to transfer between units and consults from other specialties, were particularly vulnerable processes. Conclusion With the risk of bias in mind, it is concluded that more than half of the RCARs described erroneous verbal communication between staff members as root causes of or contributing factors of severe patient safety incidents. The RCARs rich descriptions of the incidents revealed the organisational factors and needs related to these errors.
Cortisol-Induced Increases of Plasma Oxytocin Levels Predict Decreased Immediate Free Recall of Unpleasant Words

Cortisol and oxytocin have been shown to interact in both the regulation of stress responses and in memory function. In the present study we administered cortisol to 35 healthy female subjects in a within-subject double-blind placebo-controlled design, while measuring oxytocin levels, adrenocorticotropic hormone (ACTH) levels, and free recall of pleasant and of unpleasant words. We found that cortisol administration suppressed ACTH levels and (1) induced a decrease in oxytocin associated with ACTH suppression and (2) an increase in oxytocin that was independent from ACTH suppression. This cortisol-induced increase in plasma oxytocin was associated with a selective decrease in immediate free recall of unpleasant words from primacy positions. The present results add to evidence that cortisol-induced increases in oxytocin could mediate some of the effects of stress and cortisol on memory, and possibly play a role in the regulation of the hypothalamo-pituitary–adrenal stress response. This mechanism could significantly impact affective and social behaviors, in particular during times of stress.
Classifiers for the causes of data loss using packet-loss signatures

A necessary step in the development of next-generation congestion control mechanisms is the ability to accurately classify the root cause(s) of observed data loss and to develop responses tailored to the particular cause. Toward this end, we are developing a classification mechanism based on the collection and analysis of what we term packet-loss signatures, which describe the patterns of packet loss in the current transmission window. We are exploring the application of complexity theory to the problem of learning the underlying structure (or lack thereof) of these signatures, and studying the relationship between such underlying structure and the system conditions responsible for its generation. In this paper, we describe the algorithm for determining the complexity of packet-loss signatures, show how complexity measures can be mapped to the underlying causes of packet loss, and provide experimental results demonstrating the effectiveness of our approach.