Miracle-dz/UniFAR-FTUs huggingface dataset:
Detrimental dermal wound healing: What can we learn from the oral mucosa?

Wounds in adults are frequently accompanied by scar formation. This scar can become fibrotic due to an imbalance between extracellular matrix (ECM) synthesis and ECM degradation. Oral mucosal wounds, however, heal in an accelerated fashion, displaying minimal scar formation. The exact mechanisms of scarless oral healing are yet to be revealed. This review highlights possible mechanisms involved in the difference between scar‐forming dermal vs. scarless oral mucosal wound healing. Differences were found in expression of ECM components, such as procollagen I and tenascin‐C. Oral wounds contained fewer immune mediators, blood vessels, and profibrotic mediators but had more bone marrow–derived cells, a higher reepithelialization rate, and faster proliferation of fibroblasts compared with dermal wounds. These results form a basis for further research that should be focused on the relations among ECM, immune cells, growth factors, and fibroblast phenotypes, as understanding scarless oral mucosal healing may ultimately lead to novel therapeutic strategies to prevent fibrotic scars.
The Relation Between Obsessive-Compulsive Traits, Frontal Lobe Functioning, and Visual Recall

The authors of the current study administered the Wisconsin Card Sorting Test (Heaton, Chelune, Talley, Kay, & Curtiss, 1993), the Maudsley Obsessional– Compulsive Inventory (MOCI; Hodgson & Rachman, 1977), and the ReyOsterrieth Complex Figure (Lezak, 1995) to 32 undergraduate students in order to test a model in which the effects of frontal lobe functioning on visual recall are mediated by obsessive–compulsive traits. Frontal lobe functioning predicted scores on 1 of the 4 MOCI subscales (i.e., slowness) and visual recall. However, obsessive–compulsive traits did not mediate the relation between frontal lobe dysfunction and visual recall as predicted. We present a revised model of the relation between frontal lobe functioning, visual recall, and obsessive–compulsive traits. KELLI D. NELSON
Effects of 25 mg oxazepam on emotional mimicry and empathy for pain: a randomized controlled experiment

Emotional mimicry and empathy are mechanisms underlying social interaction. Benzodiazepines have been proposed to inhibit empathy and promote antisocial behaviour. First, we aimed to investigate the effects of oxazepam on emotional mimicry and empathy for pain, and second, we aimed to investigate the association of personality traits to emotional mimicry and empathy. Participants (n=76) were randomized to 25 mg oxazepam or placebo. Emotional mimicry was examined using video clips with emotional expressions. Empathy was investigated by pain stimulating the participant and a confederate. We recorded self-rated experience, activity in major zygomatic and superciliary corrugator muscles, skin conductance, and heart rate. In the mimicry experiment, oxazepam inhibited corrugator activity. In the empathy experiment, oxazepam caused increased self-rated unpleasantness and skin conductance. However, oxazepam specifically inhibited neither emotional mimicry nor empathy for pain. Responses in both experiments were associated with self-rated empathic, psychopathic and alexithymic traits. The present results do not support a specific effect of 25 mg oxazepam on emotional mimicry or empathy.
Calcineurin-Inhibitor Minimization in Liver Transplant Patients with Calcineurin-Inhibitor-Related Renal Dysfunction: A Meta-Analysis

Background Introduction of calcineurin-inhibitor (CNI) has made transplantation a miracle in the past century. However, the side effects of long-term use of CNI turn out to be one of the major challenges in the current century. Among these, renal dysfunction attracts more and more attention. Herein, we undertook a meta-analysis to evaluate the efficacy and safety of calcineurin-inhibitor (CNI) minimization protocols in liver transplant recipients with CNI-related renal dysfunction. Methods We included randomized trials with no year and language restriction. All data were analyzed using random effect model by Review Manager 5.0. The primary endpoints were glomerular filtration rate (GFR), serum creatinine level (sCr) and creatinine clearance rate (CrCl), and the secondary endpoints were acute rejection episodes, incidence of infection and patient survival at the end of follow-up. Results GFR was significantly improved in CNI minimization group than in routine CNI regimen group (Z = 5.45, P<0.00001; I2 = 0%). Likely, sCr level was significantly lower in the CNI minimization group (Z = 2.84, P = 0.005; I2 = 39%). However, CrCl was not significantly higher in the CNI minimization group (Z = 1.59, P = 0.11; I2 = 0%). Both acute rejection episodes and patient survival were comparable between two groups (rejection: Z = 0.01, P = 0.99; I2 = 0%; survival: Z = 0.28, P = 0.78; I2 = 0%, respectively). However, current CNI minimization protocols may be related to a higher incidence of infections (Z = 3.06, P = 0.002; I2 = 0%). Conclusion CNI minimization can preserve or even improve renal function in liver transplant patients with renal impairment, while sharing similar short term acute rejection rate and patient survival with routine CNI regimen.
Interdisciplinary Exploration Supports Sternberg’s Expansion of Giftedness

Robert Sternberg’s (2017) Active Concerned Citizenship and Ethical Leadership (ACCEL) framework provides a helpful way to align gifted education with the complexities of 21st-century socioeconomic and cultural environments. The recommendation that we shift away from pseudoquantitative precision in conceptions of giftedness aligns with similar recommendations in other fields including political science, economics, and mathematics. The emphases on ethics and wisdom are reinforced by analyses of the need for more ethical awareness in societies. These analyses arise from research and theory in other fields, including ethical philosophy, political science, economics, history, sociology, and journalism. These transdisciplinary similarities are interpreted to be conceptual triangulation supporting the importance of Sternberg’s model as a catalyst for the development of more holistic conceptions of giftedness and talent.
Correction: Effect of Spaceflight on the Circadian Rhythm, Lifespan and Gene Expression of Drosophila melanogaster

Space travelers are reported to experience circadian rhythm disruption during spaceflight. However, how the space environment affects circadian rhythm is yet to be determined. The major focus of this study was to investigate the effect of spaceflight on the Drosophila circadian clock at both the behavioral and molecular level. We used China’s Shenzhou-9 spaceship to carry Drosophila. After 13 days of spaceflight, behavior tests showed that the flies maintained normal locomotor activity rhythm and sleep pattern. The expression level and rhythm of major clock genes were also unaffected. However, expression profiling showed differentially regulated output genes of the circadian clock system between space flown and control flies, suggesting that spaceflight affected the circadian output pathway. We also investigated other physiological effects of spaceflight such as lipid metabolism and lifespan, and searched genes significantly affected by spaceflight using microarray analysis. These results provide new information on the effects of spaceflight on circadian rhythm, lipid metabolism and lifespan. Furthermore, we showed that studying the effect of spaceflight on gene expression using samples collected at different Zeitgeber time could obtain different results, suggesting the importance of appropriate sampling procedures in studies on the effects of spaceflight.
Activation of the calcium-sensing receptor induces deposition of tight junction components to the epithelial cell plasma membrane

François Jouret, Jingshing Wu, Michael Hull, Vanathy Rajendran, Bernhard Mayr, Christof Schöfl, John Geibel and Michael J. Caplan* Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA University of Liege Hospital (ULg CHU), Division of Nephrology and GIGA Cardiovascular Sciences, 4000 Liège, Belgium Division of Endocrinology and Diabetes, Department of Medicine I, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany
ART Suppresses Plasma HIV-1 RNA to a Stable Set Point Predicted by Pretherapy Viremia

Current antiretroviral therapy is effective in suppressing but not eliminating HIV-1 infection. Understanding the source of viral persistence is essential for developing strategies to eradicate HIV-1 infection. We therefore investigated the level of plasma HIV-1 RNA in patients with viremia suppressed to less than 50–75 copies/ml on standard protease inhibitor- or non-nucleoside reverse transcriptase inhibitor-containing antiretroviral therapy using a new, real-time PCR-based assay for HIV-1 RNA with a limit of detection of one copy of HIV-1 RNA. Single copy assay results revealed that >80% of patients on initial antiretroviral therapy for 60 wk had persistent viremia of one copy/ml or more with an overall median of 3.1 copies/ml. The level of viremia correlated with pretherapy plasma HIV-1 RNA but not with the specific treatment regimen. Longitudinal studies revealed no significant decline in the level of viremia between 60 and 110 wk of suppressive antiretroviral therapy. These data suggest that the persistent viremia on current antiretroviral therapy is derived, at least in part, from long-lived cells that are infected prior to initiation of therapy.
Escribiendo Juntos: Toward a Collaborative Model of Multiliterate Family Literacy in English Only and Anti-immigrant Contexts

This article describes an after-school family literacy program as a model of multiliterate collaboration under and against English Only and anti-immigrant conditions. The model reveals how state politics surrounding language, ethnicity, and citizenship may interact with the activity systems of family literacy programs to redefine what counts as sanctioned language and literacy learning within school spaces. This article details the findings of a qualitative study and includes the goals and curriculum of the program, as well as the recruiting mechanisms, participants, participant feedback, and participant experiences. Findings from the study reveal the role of parental investment in language and literacy learning, language co-construction, and honoring of all languages, cultures, and experiences. This family literacy model contributes to literacy studies by offering possibilities for future school-sponsored, multiliterate family literacy research collaborations to draw from and extend the language and literacy practices and funds of knowledge of ELL students, parents, teachers, and literacy scholars working within English Only and anti-immigrant contexts.
Increased photoreactivity of DOC by acidification: Implications for the carbon cycle in humic lakes

Effects of ultraviolet (UV)‐B radiation and acidification on pelagic carbon flux in a humic lake (dissolved organic carbon [DOC] ~15 mg C L−1) were studied in a mesocosm experiment during the summer of 2000. Triplicate tanks (107 liters volume, 1 m high) were exposed to natural solar radiation, a daily extra dose of UV‐B radiation, or kept dark. One set of tanks was submitted to a decrease in pH (from 5.7 to 4.7), and one set was kept at the natural pH level. During 70 d, water samples were taken regularly from the mesocosms for measurements of DOC, absorbance, dissolved inorganic carbon (DIC), and pH. Additionally, we regularly incubated samples to measure photooxidation rates, primary production, and community respiration. We found an increase in the photooxidation rates in the acidified mesocosms relative to ambient pH. The greater abiotic production of DIC (i.e., photooxidation) in acidified conditions could explain ~27% of the decline in DOC in the same conditions. Laboratory experi ments were done to test the effects of pH on the dissolved organic matter (DOM) photoreactivity. At lower pH values, we found both higher abiotic DIC production and specific absorbance fading, relative to neutral pH values in water from a humic lake. In a separate experiment, samples were exposed to prolonged irradiation under laboratory conditions, resulting in complete loss of absorptivity in the wavelengths between 290 and 400 nm. Decreases in DOC in the long‐term exposure caused by photochemical mineralization were ~45 and 55% of the initial pool for natural pH and acidified samples, respectively, at the end of the experiment. An increase in the dissolved organic matter photoreactivity by acidification could be an important mechanism to explain the increased water transparency and in‐lake DOC removal in acid lakes found in several previous studies.
Lifetimes of tidally limited star clusters with different radii

We study the escape rate of stars, (N)over dot, from clusters with different radii on circular orbits in a tidal field using analytical predictions and direct N-body simulations. We find that (N)over dot depends on the ratio R equivalent to r(h)/r(J), where r(h) is the half-mass radius and r(J) the radius of the zero-velocity surface around the cluster. For R greater than or similar to 0.05, the 'tidal regime', there is almost no dependence of (N)over dot on R. To first order this is because the fraction of escapers per half-mass relaxation time, t(rh), scales approximately as R(3/2), which cancels out the r(h)(3/2) term in t(rh). For R less than or similar to 0.05, the 'isolated regime', (N)over dot scales as R(-3/2). The dissolution time-scale, t(dis), falls in three regimes. Clusters that start with their initial R, R(i), in the tidal regime dissolve completely in this regime and their t(dis) is, therefore, insensitive to the initial r(h). Our model predicts that R(i) has to be 10(-20)-10(-10) for clusters to dissolve completely in the isolated regime. This means that realistic clusters that start with R(i) less than or similar to 0.05 always expand to the tidal regime before final dissolution. Their t(dis) has a shallower dependence on Ri than what would be expected when t(dis) is a constant times t(rh). For realistic values of R(i), the lifetime varies by less than a factor of 1.5 due to changes in R(i). This implies that the 'survival' or 'vital' diagram for globular clusters should allow for more small clusters to survive. We note that with our result it is impossible to explain the universal peaked mass function of globular cluster systems by dynamical evolution from a power-law initial mass function, since the peak will be at lower masses in the outer parts of galaxies. Our results finally show that in the tidal regime t(dis) scales as N(0.65)/omega, with omega the angular frequency of the cluster in the host galaxy.
Prevalence of cardiovascular disease risk factors among National Football League players.

CONTEXT Concern exists about the cardiovascular health implications of large size among professional football players and those players who aspire to professional status. OBJECTIVES To assess cardiovascular disease (CVD) risk factors in active National Football League (NFL) players and to compare these findings with data from the Coronary Artery Risk Development in Young Adults (CARDIA) study. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional study of 504 active, veteran football players from a convenience sample of 12 NFL teams at professional athletic training facilities between April and July 2007. Data were compared with men of the same age in the general US population (CARDIA study, a population-based observational study of 1959 participants aged 23 to 35 years recruited in 1985-1986). MAIN OUTCOME MEASURES Prevalence of CVD risk factors (hypertension, dyslipidemia, glucose intolerance, and smoking). RESULTS The NFL players were less likely to smoke when compared with the CARDIA group (0.1% [n = 1]; 95% confidence interval [CI], 0%-1.4%; vs 30.5% [n = 597]; 95% CI, 28.5%-32.5%; P < .001). Despite being taller and heavier, NFL players had significantly lower prevalence of impaired fasting glucose (6.7% [n = 24]; 95% CI, 4.6%-8.7%; vs 15.5% [n = 267]; 95% CI, 13.8%-17.3%; P < .001). The groups did not differ in prevalence of high total cholesterol and low-density lipoprotein cholesterol (LDL-C), low high-density lipoprotein cholesterol (HDL-C), or high triglycerides. Hypertension (13.8% [n = 67]; 95% CI, 11.0%-16.7%; vs 5.5% [n = 108]; 95% CI, 4.6%-6.6%) and prehypertension (64.5% [n = 310]; 95% CI, 58.3%-70.7%; vs 24.2% [n = 473]; 95% CI, 22.3%-26.1%) were significantly more common in NFL players than in the CARDIA group (both P < .001). Large size measured by body mass index (BMI) was associated with increased blood pressure, LDL-C, triglycerides, and fasting glucose, and decreased HDL-C. CONCLUSIONS Compared with a sample of healthy young-adult men, a sample of substantially larger NFL players had a lower prevalence of impaired fasting glucose, less reported smoking, a similar prevalence of dyslipidemia, and a higher prevalence of hypertension. Increased size measured by BMI was associated with increased CVD risk factors in this combined population.
The Value of Brachial-Ankle Pulse Wave Velocity as a Predictor of Coronary Artery Disease in High-Risk Patients

Background and Objectives Arterial stiffness has been known as an independent contributory factor for coronary artery disease (CAD). Brachial-ankle pulse wave velocity (baPWV) is widely used as a simple noninvasive measure of arterial stiffness. The aim of our study was to test whether baPWV had predictive value for CAD in the subset of patients with high pretest probability. Subjects and Methods We enrolled 174 consecutive patients who were referred for evaluation of suspected CAD, and who underwent both baPWV measurement and computed tomography (CT) for coronary artery calcium scoring (CACS) as part of a diagnostic work-up. Subsequently, 160 of those patients underwent invasive coronary angiography. The CAD indices consisted of 1) CACS, 2) modified Gensini scoring system, and 3) presence of obstructive CAD and 4) multi-vessel obstructive CAD. Results baPWV correlated with CACS (r=0.25, p=0.001), but not with modified Gensini scoring (r=0.10, p=0.19). However, after adjustment for factors influencing PWV, baPWV no longer correlated with CACS (r=0.14, p=0.14). By receiver operating characteristic (ROC) curve analysis, baPWV was neither a sensitive nor specific index for predicting the presence of obstructive CAD or multi-vessel obstructive CAD (sensitivity: 53% and 59%; specificity: 50% and 55%, respectively). Conclusion Our findings demonstrated that baPWV is associated with CACS, however, this may be primarily attributed to common risk factors, such as age. Furthermore, baPWV may be of limited value in identifying patients at risk for CAD.
The joy of winning and the frustration of losing: A psychophysiological analysis of emotions in first-price sealed-bid auctions.

Research on emotions suggests that auction outcomes may elicit an aversive “frustration of losing” as well as a rewarding “joy of winning” response. However, little is known about the intensity of these emotional reactions and how they relate to other factors in the auction process. In this article, we present an experiment in which subjects participated in a sequence of first-price sealed-bid auctions. The psychophysiological measures skin conductance response (SCR) and heart rate (HR) were recorded as proxies for both the intensity and the valence of emotions. Our results show that the deceleratory responses in HR when losing an auction are stronger than when winning an auction. The drop in HR itself can be interpreted as a reaction to stimuli with negative emotional valence. Moreover, we found that winning an auction induces a stronger SCR compared with losing an auction. Interestingly, this effect even holds for different value classes and different amounts of payoffs. Moreover, we show that bidders’ SCR amplitude increases in the relation to the amount of money at stake. However, we cannot make a definite determination as to whether the valuation or the potential nominal payoff triggers this effect. We conclude that psychophysiological methodologies are appropriate for the measurement of rewarding, as well as immediate aversive emotions in market decision making, and even allow identifying fined-grained emotional characteristics.
Towards an integrated framework of professional partnership performance: The role of formal governance and strategic planning

Conventional wisdom identifies human capital and organizational reputation as the critical resources explaining professional partnership (PP) performance. PPs have increasingly adopted organizational practices like strategic planning and formal governance, however, which have long been alien in highly professionalized contexts. In order to test the influence of both these classic resources and the newly adopted practices on PP performance, as well as the mediating mechanisms— that is, client attraction and retention as well as organizational efficiency—through which this influence is channeled, we develop an integrated theoretical framework of PP performance. We test the resulting hypotheses using survey and objective data collected on 196 Dutch law firms. Our findings provide new insights into the drivers of PP performance and the complex interrelationships between PP resources and newly adopted practices.
Covariance-Based Synaptic Plasticity in an Attractor Network Model Accounts for Fast Adaptation in Free Operant Learning

In free operant experiments, subjects alternate at will between targets that yield rewards stochastically. Behavior in these experiments is typically characterized by (1) an exponential distribution of stay durations, (2) matching of the relative time spent at a target to its relative share of the total number of rewards, and (3) adaptation after a change in the reward rates that can be very fast. The neural mechanism underlying these regularities is largely unknown. Moreover, current decision-making neural network models typically aim at explaining behavior in discrete-time experiments in which a single decision is made once in every trial, making these models hard to extend to the more natural case of free operant decisions. Here we show that a model based on attractor dynamics, in which transitions are induced by noise and preference is formed via covariance-based synaptic plasticity, can account for the characteristics of behavior in free operant experiments. We compare a specific instance of such a model, in which two recurrently excited populations of neurons compete for higher activity, to the behavior of rats responding on two levers for rewarding brain stimulation on a concurrent variable interval reward schedule (Gallistel et al., 2001). We show that the model is consistent with the rats' behavior, and in particular, with the observed fast adaptation to matching behavior. Further, we show that the neural model can be reduced to a behavioral model, and we use this model to deduce a novel “conservation law,” which is consistent with the behavior of the rats.