Miracle-dz/UniFAR-FTUs huggingface dataset:
Engagement of visual fixation suppresses sensory responsiveness and multisensory integration in the primate superior colliculus

Neurons in the intermediate and deep layers of the superior colliculus (SC) often exhibit sensory‐related activity in addition to discharging for saccadic eye movements. These two patterns of activity can combine so that modifications of the sensory response can lead to changes in orienting behaviour. Can behavioural factors, however, influence sensory activity? In this study of rhesus monkeys, we isolate one behavioural factor, the state of visual fixation, and examine its influences on sensory processing and multisensory integration in the primate SC. Two interleaved fixation conditions were used: a FIX condition requiring exogenous fixation of a visible fixation point; and a FIX‐BLINK condition, requiring endogenous fixation in the absence of a visible fixation point. Neurons of the SC were influenced by fixation state, exhibiting both lower levels of sensory activity and reduced multisensory interactions when fixation was exogenously engaged on a visible fixation point. These results are consistent with active visual fixation suppressing responses to extraneous stimuli, and thus demonstrate that sensory processing and multisensory responses in the SC are not dependent solely on the physical properties of the sensory environment, but are also dynamically influenced by the behavioural state of the animal.
Cost-Benefit Analysis and Emission Reduction of Energy Efficient Lighting at the Universiti Tenaga Nasional

This paper reports the result of an investigation on the potential energy saving of the lighting systems at selected buildings of the Universiti Tenaga Nasional. The scope of this project includes evaluation of the lighting system in the Library, Admin Building, College of Engineering, College of Information Technology, Apartments, and COE Food court of the university. The main objectives of this project are to design the proper retrofit scenario and to calculate the potential electricity saving, the payback period, and the potential environmental benefits. In this survey the policy for retrofitting the old lighting system with the new energy saving LEDs starts with 10% for the first year and continues constantly for 10 years until all the lighting systems have been replaced. The result of the life cycle analysis reveals that after four years, the selected buildings will bring profit for the investment.
Assessment of commercial laboratories performing hair mineral analysis.

CONTEXT Hair mineral analysis is being used by health care practitioners and promoted by laboratories as a clinical assessment tool and to identify toxic exposures, despite a 1985 study that found poor reliability for this test. OBJECTIVE To assess whether the reliability of data from commercial laboratories advertising multimineral hair analyses for nutritional or toxicity assessment has improved since the 1985 study. DESIGN, SETTING, AND PARTICIPANTS A split hair sample taken from near the scalp of a single healthy volunteer was submitted for analysis to 6 commercial US laboratories, which analyze 90% of samples submitted for mineral analysis in the United States. MAIN OUTCOME MEASURES Agreement of test results for each analyte, laboratory reference ranges, laboratory characteristics, and interpretation of health implications. RESULTS Laboratory differences in highest and lowest reported mineral concentrations for the split sample exceeded 10-fold for 12 minerals, and statistically significant (P<.05) extreme values were reported for 14 of the 31 minerals that were analyzed by 3 or more laboratories. Variations also were found in laboratory sample preparation methods and calibration standards. Laboratory designations of normal reference ranges varied greatly, resulting in conflicting classifications (high, normal, or low) of nearly all analyzed minerals. Laboratories also provided conflicting dietary and nutritional supplement recommendations based on their results. CONCLUSIONS Hair mineral analysis from these laboratories was unreliable, and we recommend that health care practitioners refrain from using such analyses to assess individual nutritional status or suspected environmental exposures. Problems with the regulation and certification of these laboratories also should be addressed.
Effect of vaccination of the dam on rotavirus infection in young calves

Vaccination of cows with a combined, inactivated, adjuvanted rotavirus and Escherichia coli vaccine resulted in increased neutralising antibody titres to rotavirus in serum and colostral whey. Evidence was obtained that vaccination resulted in a decreased incidence of rotavirus shedding and of abnormal faeces or diarrhoea in young calves fed colostrum and milk from the vaccinated dams. The E coli component of the vaccine was not evaluated because no natural challenge was evident.
Opus: University of Bath Online Publication Store Title: Altered Engagement of Autobiographical Memory Networks in Adult Offspring of Postnatally Depressed Mothers Altered Engagement of Autobiographical Memory Networks in Adult Offspring of Postnatally Depressed Mothers

(2016) Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers. Biological Psychology, 118. pp. This version is made available in accordance with publisher policies. Please cite only the published version using the reference above. Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers.Biological Psychology This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  we studied young adult offspring of mothers with postnatal depression (PND)  we examined prefrontal regulation of autobiographical memories involving the mother  PND offspring differences were only found for recall of pleasant memories  there was reduced prefrontal connectivity with posterior cingulate and precuneus  this mechanism might increase risk for psychopathology in offspring of PND mothers Abstract Maternal depression is associated with increased risk for offspring mood and anxiety disorders. One possible impact of maternal depression during offspring development is on the emotional autobiographical memory system. We investigated the neural mechanisms of emotional autobiographical memory in adult offspring of mothers with postnatal depression (N = 16) compared to controls (N = 21). During fMRI, recordings of participants describing one pleasant and one unpleasant situation with their mother and with a companion, were used as prompts to relive the situations. Compared to controls we predicted the PND offspring would show: greater activation in medial and posterior brain regions implicated in autobiographical memory and rumination; and decreased activation in lateral prefrontal cortex and decreased connectivity between lateral prefrontal and posterior regions, reflecting reduced control of autobiographical recall. For negative situations, we found no group differences. For positive situations with their mothers, PND offspring showed higher activation than controls in left lateral prefrontal cortex, right frontal pole, cingulate cortex and precuneus, and lower connectivity of right middle frontal gyrus, left middle temporal gyrus, thalamus and lingual gyrus with the posterior cingulate. Our results are consistent with adult offspring of PND mothers having less efficient prefrontal regulation of personally relevant pleasant autobiographical memories.
Quadratic finite element approximation of the Signorini problem

Applying high order finite elements to unilateral contact variational inequalities may provide more accurate computed solutions, compared with linear finite elements. Up to now, there was no significant progress in the mathematical study of their performances. The main question is involved With the modeling of the nonpenetration Signorini condition on the discrete solution along the contact region. In this work we describe two nonconforming quadratic finite element approximations of the Poisson-Signorini problem. responding to the crucial practical concern of easy implementation, and we present the numerical analysis of their efficiency. By means of Falk's Lemma we prove optimal and quasi-optimal convergence rates according to the regularity of the exact solution.
Screening Examination of Premature Infants for Retinopathy of Prematurity

This statement revises a previous statement on screening of preterm infants for retinopathy of prematurity (ROP) that was published in 2001. ROP is a pathologic process that occurs only in immature retinal tissue and can progress to a tractional retinal detachment, which can result in functional or complete blindness. Recent development of peripheral retinal ablative therapy using laser photocoagulation has resulted in the possibility of markedly decreasing the incidence of this poor visual outcome, but the sequential nature of ROP creates a requirement that at-risk preterm infants be examined at proper times to detect the changes of ROP before they become permanently destructive. This statement presents the attributes on which an effective program for detecting and treating ROP could be based, including the timing of initial examination and subsequent reexamination intervals.
Kgp and RgpB, but Not RgpA, Are Important for Porphyromonas gingivalis Virulence in the Murine Periodontitis Model

ABSTRACT The contributions of three proteinase genes (rgpA, rgpB, and kgp) to the virulence of Porphyromonas gingivalis W50 were investigated in the murine periodontitis model. Mice were orally inoculated with eight doses (1 × 1010 cells per dose) of rgpA, rgpB, kgp, rgpA rgpB, or rgpA rgpB kgp isogenic mutants, and the level of alveolar bone loss, immune response induced, and number of bacterial cells per half maxilla were compared with those of animals inoculated with wild-type P. gingivalis. The kgp, rgpB, rgpA rgpB, and rgpA rgpB kgp isogenic mutants induced significantly (P < 0.05) less bone loss than the rgpA isogenic mutant and the wild type did, and the virulence of the rgpA isogenic mutant and the wild type were not significantly different. Mice inoculated with the wild type or the rgpA isogenic mutant exhibited significantly (P < 0.01) more P. gingivalis cells per half maxilla than mice inoculated with rgpB, kgp, rgpA rgpB, and rgpA rgpB kgp isogenic mutants or nonchallenged mice did, as determined using real-time PCR. A significant positive correlation was found between the number of P. gingivalis cells detected per half maxilla and the amount of alveolar bone loss induced. Enzyme-linked immunosorbent assay results showed that each isogenic mutant and the wild type induced a predominant P. gingivalis antigen-specific immunoglobulin G3 (IgG3) response. Furthermore, the kgp and rgpA rgpB kgp isogenic mutants induced significantly (P < 0.05) lower IgG3 antibody responses than the responses induced by the wild type or the rgpA, rgpB, and rgpA rgpB isogenic mutants. The results suggest that the order in which the proteinases contribute to the virulence of P. gingivalis in the murine periodontitis model is Kgp ≥ RgpB ≫ RgpA.
Michelson Interferometer Thermo-Optic Switch on SOI With a 50-µW Power Consumption

We demonstrate photonic ultra-efficient thermo-optic switches on a 220-nm silicon-on-insulator platform. We used several approaches to increase the tuning efficiency of the switches. We used folded waveguides in a Michelson interferometer configuration to increase the optical interaction length of the light with the heated region, and used a suspended structure to improve thermal isolation. An ultra-low switching power of 50 μW is realized with an extinction ratio of over 26 dB for the transverse electric mode at 1550 nm. The 10%-90% response time of the switch is 1.28 ms, including a 780 μs rise time and a 500 μs fall time. Compared with the best thermo-optic switch in the literature, our device shows approximately an order of magnitude reduction in power consumption.
Flagging the Topographic Impact on the SMOS Signal

Soil moisture retrieval models from the Soil Moisture and Ocean Salinity (SMOS) mission, which is an L-band microwave interferometer, are based on multiangular measurements and make use of the emissivity angular signature. Mountainous areas modify local incidence angles, implying significant impacts on brightness temperatures and, consequently, on soil moisture retrievals. The purpose of this paper is to establish a criterion in quantifying the relevance of topographic impacts at the SMOS scale ( ~ 40 km). The goal is thus to define a method of flagging the pixels according to the relative impact of topography on the brightness temperature. The proposed method uses the variogram of digital elevation model images. As a result, a map of the pixels to be flagged is produced to ensure that no soil moisture retrievals are carried out on pixels that are affected by strong topographic effects. As validation, a model was also used to simulate differences between brightness temperature variations between mountainous areas and flat surfaces.
Event-Related Potentials Reveal Rapid Verification of Predicted Visual Input

Human information processing depends critically on continuous predictions about upcoming events, but the temporal convergence of expectancy-based top-down and input-driven bottom-up streams is poorly understood. We show that, during reading, event-related potentials differ between exposure to highly predictable and unpredictable words no later than 90 ms after visual input. This result suggests an extremely rapid comparison of expected and incoming visual information and gives an upper temporal bound for theories of top-down and bottom-up interactions in object recognition.
Symptoms at Onset in First Episode Schizophrenia: Caregivers Perspectives

Background: Early recognition of symptoms is important in the management of psychosis. Caregivers understanding and attribution of symptoms plays a major role in treatment selection. Aim: The aim was to identify the various symptoms cluster recognized by caregivers at illness onset in first episode schizophrenia. Subjects and Methods: In a cross-sectional study 40 key caregivers of patients with first episode of Schizophrenia (International Classification of Diseases-10) attending the outpatient services of Schizophrenia Research Foundation were recruited. Caregivers were assessed using a questionnaire adapted from the Psychiatric and Personal History Schedule. Statistical Analysis: Principal component (PCP) analysis. Results: Caregivers were predominantly women. Parents (58%), siblings (18%), spouse (12%), and children (12%) formed the sample. The caregiver easily recognized depressive symptoms. An analysis was done to analyze symptom data rated on the caregiver questionnaire indicated a four-factor solution. PCP analysis produced a clear depressive, anxious, irritable, and vegetative factor (Eigenvalue >0.05). Caregivers (40%) attributed present lifestyle as causality. The first contact of help in almost half of the sample (45%) was to a psychiatric facility. Conclusion: Caregiver's perception about mental illness and ability to identify the four factors has important treatment implications. Studying patterns of help seeking may be a useful strategy in early intervention programs.
Atrial natriuretic factor receptor on cultured Leydig tumor cells: ligand binding and photoaffinity labeling.

Atrial natriuretic factor (ANF) is a peptide hormone discovered recently from the heart atrium that possesses potent natriuretic and vasorelaxant activities. Recently we found that ANF markedly stimulates intracellular cGMP and almost completely inhibits cAMP accumulation in testicular interstitial tumor cells [Pandey, K. N. , Kovacs, W. J., & Inagami, T. (1985) Biochem. Biophys. Res. Commun. 133, 800-806]. These actions of ANF suggest the presence of ANF receptors in testicular interstitial cells. In this study, cultured murine Leydig tumor cells have been shown to contain specific binding sites for ANF. Saturation binding studies indicated a single class of binding sites with a Kd of 5 X 10(-9) M at a density of 2 X 10(6) sites/cell. The binding of mono[125I]iodo-ANF (125I-ANF) was competed by unlabeled ANF in a dose-dependent manner. Hormones unrelated to ANF such as angiotensin I, bovine luteinizing hormone, and human chorionic gonadotropin were not able to compete against 125I-ANF. The binding of 125I-ANF was rapid, reaching maximum levels in 15 min at 4 degrees C. At 37 degrees C, the cell-bound 125I label was quickly decreased. Pretreatment of cells with NH4Cl, chloroquine, or NaN3 resulted in significant increases in maximum levels of the cell-bound 125I radioactivity. A photoaffinity reagent for ANF receptor was prepared by reacting ANF with succinimido 4-azidobenzoate, and resultant 4-azidobenzoyl- (AZB-) ANF was purified by high-performance liquid chromatography (HPLC). AZB-ANF was radioiodinated by use of chloramine T and purified again by HPLC. (ABSTRACT TRUNCATED AT 250 WORDS)
Measuring MWE Compositionality Using Semantic Annotation

This paper reports on an experiment in which we explore a new approach to the automatic measurement of multi-word expression (MWE) compositionality. We propose an algorithm which ranks MWEs by their compositionality relative to a semantic field taxonomy based on the Lancaster English semantic lexicon (Piao et al., 2005a). The semantic information provided by the lexicon is used for measuring the semantic distance between a MWE and its constituent words. The algorithm is evaluated both on 89 manually ranked MWEs and on McCarthy et al's (2003) manually ranked phrasal verbs. We compared the output of our tool with human judgments using Spearman's rank-order correlation coefficient. Our evaluation shows that the automatic ranking of the majority of our test data (86.52%) has strong to moderate correlation with the manual ranking while wide discrepancy is found for a small number of MWEs. Our algorithm also obtained a correlation of 0.3544 with manual ranking on McCarthy et al's test data, which is comparable or better than most of the measures they tested. This experiment demonstrates that a semantic lexicon can assist in MWE compositionality measurement in addition to statistical algorithms.
Flying Drosophila stabilize their vision-based velocity controller by sensing wind with their antennae

Significance Insects are widely appreciated for their aerial agility, but the organization of their control system is not well understood. In particular, it is not known how they rapidly integrate information from different sensory systems—such as their eyes and antennae—to regulate flight speed. Although vision may provide an estimate of the true groundspeed in the presence of wind, delays inherent in visual processing compromise the performance of the flight speed regulator and make the animal unstable. Mechanoreceptors on the antennae of flies cannot measure groundspeed directly, but can detect changes in airspeed more quickly. By integrating information from both senses, flies achieve stable regulation of flight speed that is robust to perturbations such as gusts of wind. Flies and other insects use vision to regulate their groundspeed in flight, enabling them to fly in varying wind conditions. Compared with mechanosensory modalities, however, vision requires a long processing delay (~100 ms) that might introduce instability if operated at high gain. Flies also sense air motion with their antennae, but how this is used in flight control is unknown. We manipulated the antennal function of fruit flies by ablating their aristae, forcing them to rely on vision alone to regulate groundspeed. Arista-ablated flies in flight exhibited significantly greater groundspeed variability than intact flies. We then subjected them to a series of controlled impulsive wind gusts delivered by an air piston and experimentally manipulated antennae and visual feedback. The results show that an antenna-mediated response alters wing motion to cause flies to accelerate in the same direction as the gust. This response opposes flying into a headwind, but flies regularly fly upwind. To resolve this discrepancy, we obtained a dynamic model of the fly’s velocity regulator by fitting parameters of candidate models to our experimental data. The model suggests that the groundspeed variability of arista-ablated flies is the result of unstable feedback oscillations caused by the delay and high gain of visual feedback. The antenna response drives active damping with a shorter delay (~20 ms) to stabilize this regulator, in exchange for increasing the effect of rapid wind disturbances. This provides insight into flies’ multimodal sensory feedback architecture and constitutes a previously unknown role for the antennae.
Making positive changes.

Change is a difficult thing for firefighters to buy into. In today’s fire service, there is a lot of change, both in technology and in tactics, that is thrown at us at a blistering pace. Many of these changes have been born out of tragedies and are designed to keep us safe as we deliver professional services to the community. The other day I discussed with a firefighter the department I now serve in. This rural Virginia fire department is lacking in several key areas and is trying to improve. Some of the firefighters choose to talk bad about certain people rather than focusing their energy into changing the department for good. I posed the question to the firefighter whom I was talking with, asking him what is worse not knowing the correct way to run a department or to have knowledge of the needed changes and yet not help in implementing those changes. I choose to use the knowledge I have been given to help improve the department. James makes a bold statement in chapter four when he says; “Therefore to him, that knoweth to do good, and doeth it not, to him it is sin. ” God often puts a burden or passion within in us to help someone. When we disregard that urge to become involved James uses strong language in telling us it is sinful. Our departments and those we serve with can only know that the love of God abides within us if we are willing to go the extra mile and help them in times of need. God has given each of us skills and abilities that can be used to further the Kingdom within the fire service and truly change it for good. Why in the world would we want to stand there and choose to do nothing? Let’s resolve today to do something for God.
Enriched Riemann sphere, Morse stability and equi‐singularity in 𝒪2

The Enriched Riemann Sphere ℂ P*1 is ℂ P1 plus a set of infinitesimals, having coordinates in the Newton–Puiseux field 𝔽. Complex analysis is extended to the 𝔽‐analysis (Newton–Puiseux Analysis). The classical Morse Stability Theorem is also extended; the stability idea is used to formulate an equi‐singular deformation theorem in ℂ{x, y} (=𝒪2).