Miracle-dz/UniFAR-FTUs huggingface dataset:
Astrometric solar-system anomalies

Abstract There are at least four unexplained anomalies connected with astrometric data. Perhaps the most disturbing is the fact that when a spacecraft on a flyby trajectory approaches the Earth within 2000 km or less, it often experiences a change in total orbital energy per unit mass. Next, a secular change in the astronomical unit AU is definitely a concern. It is reportedly increasing by about 15 cm yr−1. The other two anomalies are perhaps less disturbing because of known sources of nongravitational acceleration. The first is an apparent slowing of the two Pioneer spacecraft as they exit the solar system in opposite directions. Some astronomers and physicists, including us, are convinced this effect is of concern, but many others are convinced it is produced by a nearly identical thermal emission from both spacecraft, in a direction away from the Sun, thereby producing acceleration toward the Sun. The fourth anomaly is a measured increase in the eccentricity of the Moon's orbit. Here again, an increase is expected from tidal friction in both the Earth and Moon. However, there is a reported unexplained increase that is significant at the three-sigma level. It is prudent to suspect that all four anomalies have mundane explanations, or that one or more anomalies are a result of systematic error. Yet they might eventually be explained by new physics. For example, a slightly modified theory of gravitation is not ruled out, perhaps analogous to Einstein's 1916 explanation for the excess precession of Mercury's perihelion.
Supply chain sustainability - the role of trust and relationship

This action research project aims to improve economic, social and environmental sustainability of the pre-cast concrete and construction and demolition waste supply chains through the development, trial and evaluation of an innovative supply chain management strategy. The long-term goals are to improve competitive behaviour and market sector performance and improve business process efficiency and effectiveness of public sector program delivery by influencing policy development, changing organisational behaviour and implementation development to achieve economic, social and environmentally sustainable markets. In order to facilitate this, the culture change brought about by implementing relationship management in the supply chain is investigated and this paper reports on this aspect of the project.
Social Influences on Political Information Search and Evaluation

In this paper, we consider whether simple social signals of affect influence the information search strategies and political judgments of subjects during a voting task. We randomly assigned participants to either a neutral information environment or one in which the items also indicated how many other people “liked” or “disliked” the information. We find that social cues do in fact condition the search behavior of participants; subjects in social environments engaged in different patterns of search and focused on different types of information than did subjects in the control group. However, these changes in search strategy had no effect on evaluation of the candidates or their policies. Paper presented at the annual meeting of the American Political Science Association, August 29September 1, 2013, Chicago, IL
Christian Values and Implication to Community Development as Reflected by Juvenile Delinquency Rate at Benguet State University-Elementary Laboratory School in La Trinidad,

: This study aims to determine the association of Christian Values Education to child development and how it contributes to school community development at Benguet State University Elementary Laboratory School. Specifically, the study sought to determine the relationship between the manifestation of Christian values and child development and the implication of Christian values education to school community development. The study utilized the descriptive correlation design. The study was done at the Benguet State University Elementary Laboratory School and BSU Guidance Office in La Trinidad, Benguet, Philippines. Most of the identified Christian values have generally affected the pupils' five domains of holistic development because the school teachers have religiously inculcated values into their teachings and daily disciplines in the school. However, the physical was less affected by the values of repentance, obedience, and responsibility. Likewise, cognitive domains of development were less affected by hope, trustworthiness and responsibility, which can be attributed to the rightful values that the teaching at the school was able to instil in the pupils with the sound jurisdiction of good and bad behaviours. Christian values education and holistic child development contribute to minimizing the juvenile delinquency rate, which leads to community development because a community with a very low delinquency rate implies a good community.
Bed exit prediction based on movement and posture data

Falls in nursing homes and hospitals take often place immediately after a bed exit of a patient. An alarm signaling the exit from the bed may already be too late for staff to react. In this paper we explore the possibilities of detecting the sequences of preparatory movements before the bed exit and in this way create an early warning of the preparation of bed exit. The method is described and tested using annotated accelerometer data collected from volunteers. A plausibility assessment is also done by comparing accelerometer data from hospital patients with the output of a bed alarm system. It is demonstrated that the proposed method is able to detect a bed exit already seconds before the patient actually leaves the bed.
A Dual Role for Src Homology 2 Domain–Containing Inositol-5-Phosphatase (Ship) in Immunity

In this report, we demonstrate that the Src homology 2 domain–containing inositol-5-phosphatase (SHIP) plays a critical role in regulating both B cell development and responsiveness to antigen stimulation. SHIP−/− mice exhibit a transplantable alteration in B lymphoid development that results in reduced numbers of precursor B (fraction C) and immature B cells in the bone marrow. In vitro, purified SHIP−/− B cells exhibit enhanced proliferation in response to B cell receptor stimulation in both the presence and absence of Fcγ receptor IIB coligation. This enhancement is associated with increased phosphorylation of both mitogen-activated protein kinase and Akt, as well as with increased survival and cell cycling. SHIP−/− mice manifest elevated serum immunoglobulin (Ig) levels and an exaggerated IgG response to the T cell–independent type 2 antigen trinitrophenyl Ficoll. However, only altered B cell development was apparent upon transplantation into nonobese diabetic–severe combined immunodeficient (NOD/SCID) mice. The in vitro hyperresponsiveness, together with the in vivo findings, suggests that SHIP regulates B lymphoid development and antigen responsiveness by both intrinsic and extrinsic mechanisms.
Influence of the Menopause on Ischaemic Heart Disease and its Risk Factors and on Bone Mineral Content

A comprehensive population study of women in Gothenburg, Sweden, was carried out in 1968-69. Altogether 1462 women participated (participation rate 90.1%). Five age strata were studied, i.e. women born in 1930, 1922, 1918, 1914 and 1908. The same women were restudied in 1974-1975 (participation rate 80.3% of the initial sample and 89.1% of those participating in 1968-69). In addition, a study of bone density, using photon absorptiometry, was carried out in a systematic subsample in 1976. The median age at natural menopause in the population sample was found to be 50 years and 3 months. About 5% of women aged 44 or more had stopped menstruating after hysterectomy and a similar proportion were postmenopausal as a consequence of bilateral oophorectomy. Information is also given about the percentages of the women receiving oestrogens either as substitution therapy or as oral contraceptives. Different factors influencing the age at menopause are discussed. Smoking was found to be one of the most important of these. The influence of the menopause on ischaemic heart disease and its risk factors has been studied both cross-sectionally and longitudinally. The most striking differences were found for serum cholesterol and serum triglycerides, with higher values in postmenopausal women than in premenopausal of the same ages. For bone mineral content, higher values were observed in premenopausal or recently postmenopausal women than in women of the same ages who had been postmenopausal for a long time. The observed differences in bone mineral content could not be explained by other factors studied.
Ageing makes us dyslexic

Background: The effects of typical ageing on spoken language are well known: word production is disproportionately affected while syntactic processing is relatively well preserved. Little is known, however, about how ageing affects reading. Aims: What effect does ageing have on written language processing? In particular, how does it affect our ability to read words? How does it affect phonological awareness (our ability to manipulate the sounds of our language)? Methods & Procedures: We tested 14 people with Parkinson's disease (PD), 14 typically ageing adults (TAA), and 14 healthy younger adults on a range of background neuropsychological tests and tests of phonological awareness. We then carried out an oral naming experiment where we manipulated consistency, and a nonword repetition task where we manipulated the word-likeness of the nonwords. Outcomes & Results: We find that normal ageing causes individuals to become mildly phonologically dyslexic in that people have difficulty pronouncing nonwords. People with Parkinson's disease perform particularly poorly on language tasks involving oral naming and metalinguistic processing. We also find that ageing causes difficulty in repeating nonwords. We show that these problems are associated with a more general difficulty in processing phonological information, supporting the idea that language difficulties, including poorer reading in older age, can result from a general phonological deficit. Conclusions: We suggest that neurally this age-induced dyslexia is associated with frontal deterioration (and perhaps deterioration in other regions) and cognitively to the loss of executive processes that enable us to manipulate spoken and written language. We discuss implications for therapy and treatment.
Assessing community effects on adolescent substance use and delinquency

This study investigates community-level prediction of adolescent substance use and problem behaviors using ratings by community leaders to assess the effects of four risk factors on levels of drug use and problem behaviors. Three questions are examined: (a) Can psychometrically sound measures of community leader perceptions of risk factors in their community be developed? ; (b) What is the relationship between community leader ratings of the community and student perceptions of their community? ; and (c) How are community leader ratings and student perceptions of the community related to community levels of current student substance use and serious delinquency? Results indicate that community leaders' perceptions of community risk factors demonstrate both internal validity and criterion validity. Community leaders and students demonstrate modest agreement in assessments of community risk factors. Community leaders' ratings of community norms favorable to substance use and community law enforcement permissive of substance use were related to levels of substance use reported by students. Leader ratings of low community attachment, community disorganization, and community law enforcement permissive of substance use were related to community levels of serious delinquency reported by students. © 2007 Wiley Periodicals, Inc. J Comm Psychol 35: 925–946, 2007.
Self-evaluation and self-perception of student learning in person-centred counselling training within a higher education setting

This is an account of some of the learning experiences of mature students undertaking a Level 2 Diploma course in Person-Centred Counselling over four terms in a higher education establishment in England. The central question driving this research stemmed from a desire to understand the student experience of becoming professional. Therefore the question was that of qualitative inquiry: ‘What are the experiences of mature learners on person-centred counselling courses within higher education? ’ This paper discusses students’ perceptions of training and the ways in which they evaluate their status as professionals.
Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells

Tryptases and chymases are the major proteins stored and secreted by mast cells, and they have various biological functions. However, the nature of proteases produced by basophils has been poorly characterized, particularly in mice. mMCP‐11 is the most recently discovered mast cell tryptase in mice and was originally identified as Prss34, which is transcribed in some mast cell‐like cell lines and at the early stage in the culture of BMMC with IL‐3. Curiously, Prss34 is preferentially expressed in the BM and spleen among normal tissues in contrast to other mast cell tryptases. Therefore, it remains elusive what types of cells express mMCP‐11 in vivo. Here, we show that mMCP‐11 is highly expressed by primary basophils and to a much lesser extent, by some mast cells. Prss34 transcripts were detected abundantly in primary and cultured basophils and very weakly in peritoneal mast cells or cultured BMMC. Conversely, transcripts for mMCP‐6 and mMCP‐7 tryptases were preferentially expressed by cultured and peritoneal mast cells but not basophils. We established a mMCP‐11‐specific mAb and showed that mMCP‐11 proteins are indeed expressed by primary basophils and those infiltrating the affected tissues during allergic inflammation and parasitic infections. Some primary mast cells also expressed mMCP‐11 proteins, albeit at a much lower level. Thus, basophils rather than mast cells are the major source of mMCP‐11. This is the first study to demonstrate that mouse basophils produce a trypsin‐like protease.
A Two-Stage Evaluation of Genetic Variation in Immune and Inflammation Genes with Risk of Non-Hodgkin Lymphoma Identifies New Susceptibility Locus in 6p21.3 Region

Background: Non-Hodgkin lymphoma (NHL) is a malignancy of lymphocytes, and there is growing evidence for a role of germline genetic variation in immune genes in NHL etiology. Methods: To identify susceptibility immune genes, we conducted a 2-stage analysis of single-nucleotide polymorphisms (SNP) from 1,253 genes using the Immune and Inflammation Panel. In Stage 1, we genotyped 7,670 SNPs in 425 NHL cases and 465 controls, and in Stage 2 we genotyped the top 768 SNPs on an additional 584 cases and 768 controls. The association of individual SNPs with NHL risk from a log-additive model was assessed using the OR and 95% confidence intervals (CI). Results: In the pooled analysis, only the TAP2 coding SNP rs241447 (minor allele frequency = 0.26; Thr655Ala) at 6p21.3 (OR = 1.34, 95% CI 1.17–1.53) achieved statistical significance after accounting for multiple testing (P = 3.1 × 10−5). The TAP2 SNP was strongly associated with follicular lymphoma (FL, OR = 1.82, 95%CI 1.46–2.26; p = 6.9 × 10−8), and was independent of other known loci (rs10484561 and rs2647012) from this region. The TAP2 SNP was also associated with diffuse large B-cell lymphoma (DLBCL, OR = 1.38, 95% CI 1.08–1.77; P = 0.011), but not chronic lymphocytic leukemia (OR = 1.08; 95% CI 0.88–1.32). Higher TAP2 expression was associated with the risk allele in both FL and DLBCL tumors. Conclusion: Genetic variation in TAP2 was associated with NHL risk overall, and FL risk in particular, and this was independent of other established loci from 6p21.3. Impact: Genetic variation in antigen presentation of HLA class I molecules may play a role in lymphomagenesis. Cancer Epidemiol Biomarkers Prev; 21(10); 1799–806. ©2012 AACR.
H3R42me2a is a histone modification with positive transcriptional effects

Histone posttranslational modification leads to downstream effects indirectly by allowing or preventing docking of effector molecules, or directly by changing the intrinsic biophysical properties of local chromatin. To date, little has been done to study posttranslational modifications that lie outside of the unstructured tail domains of histones. Core residues, and in particular arginines in H3 and H4, mediate key interactions between the histone octamer and DNA in forming the nucleosomal particle. Using mass spectrometry, we find that one of these core residues, arginine 42 of histone H3 (H3R42), is dimethylated in mammalian cells by the methyltransferases coactivator arginine methyltransferase 1 (CARM1) and protein arginine methyltransferase 6 (PRMT6) in vitro and in vivo, and we demonstrate that methylation of H3R42 stimulates transcription in vitro from chromatinized templates. Thus, H3R42 is a new, “nontail” histone methylation site with positive effects on transcription. We propose that methylation of basic histone residues at the DNA interface may disrupt histone:DNA interactions, with effects on downstream processes, notably transcription.
Limited resection for duodenal gastrointestinal stromal tumors: Surgical management and clinical outcome.

AIM To analyze our experience in patients with duodenal gastrointestinal stromal tumors (GIST) and review the appropriate surgical approach. METHODS We retrospectively reviewed the medical records of all patients with duodenal GIST surgically treated at our medical institution between 2002 and 2011. Patient files, operative reports, radiological charts and pathology were analyzed. For surgical therapy open and laparoscopic wedge resections and segmental resections were performed for limited resection (LR). For extended resection pancreatoduodenectomy was performed. Age, gender, clinical symptoms of the tumor, anatomical localization, tumor size, mitotic count, type of resection resectional status, neoadjuvant therapy, adjuvant therapy, risk classification and follow-up details were investigated in this retrospective study. RESULTS Nine patients (5 males/4 females) with a median age of 58 years were surgically treated. The median follow-up period was 45 mo (range 6-111 mo). The initial symptom in 6 of 9 patients was gastrointestinal bleeding (67%). Tumors were found in all four parts of the duodenum, but were predominantly located in the first and second part of the duodenum with each 3 of 9 patients (33%). Two patients received neoadjuvant medical treatment with 400 mg imatinib per day for 12 wk before resection. In one patient, the GIST resection was done by pancreatoduodenectomy. The 8 LRs included a segmental resection of pars 4 of the duodenum, 5 wedge resections with primary closure and a wedge resection with luminal closure by Roux-Y duodeno-jejunostomy. One of these LRs was done minimally invasive; seven were done in open fashion. The median diameter of the tumors was 54 mm (14-110 mm). Using the Fletcher classification scheme, 3/9 (33%) tumors had high risk, 1/9 (11%) had intermediate risk, 4/9 (44%) had low risk, and 1/9 (11%) had very low risk for aggressive behaviour. Seven resections showed microscopically negative transsection margins (R0), two showed positive margins (R1). No patient developed local recurrence during follow-up. The one patient who underwent pancreatoduodenectomy died due to progressive disease with hepatic metastasis but without evidence of local recurrence. Another patient died in complete remission due to cardiac disease. Seven of the nine patients are alive disease-free. CONCLUSION In patients with duodenal GIST, limited surgical resection with microscopically negative margins, but also with microscopically positive margins, lead to very good local and systemic disease-free survival.
Comparison of citrated native and kaolin-activated samples for thrombelastographic analysis in healthy dogs.

BACKGROUND Thrombelastographic (TEG) analysis is a test of global hemostasis in veterinary medicine; however, there have been limited comparisons of analysis of citrated native and kaolin-activated samples. OBJECTIVES The purpose of this study was to determine the variation in TEG variables between citrated native and kaolin-activated whole blood samples and to establish reference intervals for both sample types. METHODS Citrated whole blood samples were obtained from 40 healthy dogs. Thirty minutes after collection, TEG analysis was performed simultaneously on samples with and without kaolin-activation. Reaction time (R), clotting time (K), angle (α), maximum amplitude (MA), global clot strength (G), and clot lysis at 30 minutes (LY30) were recorded, and the concordance correlation coefficient (ρ(c)) was calculated for each sample type. RESULTS Significant differences between results obtained for kaolin-activated and native samples were obtained for R (mean difference -1.3 minute, P = .0009), K (-0.7 minute, P = .0003), α (+5.1º, P = .002), MA (+2.4 mm, P = .002), and G (+568 dyn/cm(2), P = . 0009). LY30 was not different between methods. There was substantial agreement between methods for G (ρ(c) = . 69) and MA (ρ(c) = . 65), moderate agreement for R (ρ(c) = . 45) and α (ρ(c) = . 44), fair agreement for K (ρ(c) = . 29), and slight agreement for LY30 (ρ(c) = . 04). CONCLUSIONS The TEG variables were significantly altered by kaolin activation; however, some agreement between sample types suggests a consistent bias. In citrated whole blood activated with kaolin, clot formation time is shortened and the amplitude of the tracing is increased, resulting in a TEG tracing that appears to indicate relative hypercoagulability compared with that obtained using native citrated whole blood samples.