Miracle-dz/UniFAR-FTUs huggingface dataset:
A multiagent genetic algorithm for global numerical optimization

In this paper, multiagent systems and genetic algorithms are integrated to form a new algorithm, multiagent genetic algorithm (MAGA), for solving the global numerical optimization problem. An agent in MAGA represents a candidate solution to the optimization problem in hand. All agents live in a latticelike environment, with each agent fixed on a lattice-point. In order to increase energies, they compete or cooperate with their neighbors, and they can also use knowledge. Making use of these agent-agent interactions, MAGA realizes the purpose of minimizing the objective function value. Theoretical analyzes show that MAGA converges to the global optimum. In the first part of the experiments, ten benchmark functions are used to test the performance of MAGA, and the scalability of MAGA along the problem dimension is studied with great care. The results show that MAGA achieves a good performance when the dimensions are increased from 20-10,000. Moreover, even when the dimensions are increased to as high as 10,000, MAGA still can find high quality solutions at a low computational cost. Therefore, MAGA has good scalability and is a competent algorithm for solving high dimensional optimization problems. To the best of our knowledge, no researchers have ever optimized the functions with 10,000 dimensions by means of evolution. In the second part of the experiments, MAGA is applied to a practical case, the approximation of linear systems, with a satisfactory result.
Monitoring rapid temporal change in a volcano with coda wave interferometry

Multiply–scattered waves typically dominate the late part of the seismic coda in local earthquake seismograms. Small medium changes that have no detectable influence on the first arrivals are amplified by multiple scattering and may thus be readily observed in the coda. We exploit this idea using Coda Wave Interferometry to monitor temporal changes at Mount Erebus Volcano, Antarctica. Erebus is one of the few volcanoes on Earth with a long–lived convecting lava lake. Large exsolved gas bubbles generate impulsive Strombolian explosions that provide a repeating seismic source of seismic energy propagating through the strongly scattering geology of the volcano. We examined these signals during a particularly active eruptive two–month period between December, 1999 and February, 2000. Early seismograms are highly reproducible throughout this period. During the first month this is also the case for the coda. Approximately midway through this period, however, the seismic coda decorrelates rapidly over a period of several days. This indicates a rapid change in the scattering properties of the volcano, likely reflecting subtle changes in the near–summit magma/conduit system that would not be discernible using direct– or single–scattered seismic wave methods.
Microbiota regulates immune defense against respiratory tract influenza A virus infection

Although commensal bacteria are crucial in maintaining immune homeostasis of the intestine, the role of commensal bacteria in immune responses at other mucosal surfaces remains less clear. Here, we show that commensal microbiota composition critically regulates the generation of virus-specific CD4 and CD8 T cells and antibody responses following respiratory influenza virus infection. By using various antibiotic treatments, we found that neomycin-sensitive bacteria are associated with the induction of productive immune responses in the lung. Local or distal injection of Toll-like receptor (TLR) ligands could rescue the immune impairment in the antibiotic-treated mice. Intact microbiota provided signals leading to the expression of mRNA for pro–IL-1β and pro–IL-18 at steady state. Following influenza virus infection, inflammasome activation led to migration of dendritic cells (DCs) from the lung to the draining lymph node and T-cell priming. Our results reveal the importance of commensal microbiota in regulating immunity in the respiratory mucosa through the proper activation of inflammasomes.
Methodological Factors in Determining Rates of Dementia in Transient Ischemic Attack and Stroke: (I) Impact of Baseline Selection Bias

Background and Purpose— Many previous studies on dementia in stroke have restrictive inclusion criteria, which may result in underestimation of dementia rates. We undertook a large prospective population-based study of all transient ischemic attack and stroke to determine the impact of study entry criteria on measured rates of pre- and postevent dementia. Methods— All patients with acute transient ischemic attack or stroke from a defined population of 92 728 are referred from primary care or at hospital admission to the Oxford Vascular Study (2002–2007) and have baseline clinical and cognitive assessment and follow-up. We examined the impact of early death, other nonavailability, and commonly used selection criteria, on measured rates of dementia. Results— Among 1236 patients (mean age/SD 75.2/12.1 years, 582 men, 403 transient ischemic attack), 139 died or were otherwise unavailable for baseline assessment, 319 had prior dependency, 425 had comorbidity, 512 were aged ≥80 years, 85 were dysphasic, and 502 were hospitalized. Pre-event dementia was 3-fold higher in patients dying preascertainment (10/47, 21%) and twice as high in other nonassessed (14/92, 15%) versus assessed patients (69/1097, 6%; P=0.0006 and P=0.002) and was several-fold higher in those with prior functional impairment (24% versus 3%; P<0.0001), age >80 years (13% versus 3%; P<0.0001), dysphasia (11% versus 7%; P<0.0001), and comorbidity (10% versus 6%; P=0.04). Findings for postevent dementia were similar: prior functional impairment (40% versus 13%; P<0.0001), age >80 years (28% versus 10%; P<0.0001), dysphasia (39% versus 15%; P<0.0001), and comorbidity (20% versus 15%; P=0.04). Conclusions— Exclusion of patients unavailable for assessment, and other widely used selection criteria, results in underestimation of the measured rate of dementia associated with transient ischemic attack and stroke.
Renal transplantation in the elderly: surgical complications and outcome with special emphasis on the Eurotransplant Senior Programme.

BACKGROUND The purpose of this retrospective study was to evaluate the results of the Eurotransplant Senior Programme (ESP) within our centre compared to elderly recipients >or=60 years from the regular Eurotransplant Kidney Allocation System (ETKAS), specifically focusing on surgical aspects. METHODS Data from 73 ESP patients (average donor/recipient age: 71.1/67.1) were compared with those from 51 patients (49.7/63.6) treated within the framework of the ETKAS program between the years 1999 and 2006. The mean follow-up was 39.5 months. RESULTS Cold ischaemic time (ESP versus ETKAS: 10.3 versus 15.0 h), duration of renal replacement therapy (42.2 versus 76.8 months), donor glomerular filtration rate (81.7 versus 109.9 ml/min/1.73 m(2)) and HLA mismatches (4.1 versus 2.4) were significantly different between the two groups (all P < 0.001). Primary graft function was seen in 74% ESP versus 69% of ETKAS patients (P > 0.05). The rate of surgical complications in the ESP versus ETKAS group was 47% versus 28% (P = 0.031) and the revision rate, 33% versus 24% (P = 0.259). Three-year patient and censored graft survival was 84% versus 92% and 85% versus 88% in the ESP and ETKAS group, respectively (all P > 0.05). Ninety-five percent of all deceased patients died with a functioning graft. CONCLUSIONS The donor and recipient pool has been markedly expanded through ESP with similar patient and graft survival compared to elderly recipients grafted according to ETKAS criteria. However, patients and their physicians should be aware of the high surgical complication rate in elderly recipients, particularly when receiving elderly donor kidneys. This might seriously influence postoperative patient management but ultimately does not compromise the transplant outcome.
Validation of 6-Minute Walk Distance as a Surrogate End Point in Pulmonary Arterial Hypertension Trials

Background— Nearly all available treatments for pulmonary arterial hypertension have been approved based on change in 6-minute walk distance (&Dgr;6MWD) as a clinically important end point, but its validity as a surrogate end point has never been shown. We aimed to validate the difference in &Dgr;6MWD against the probability of a clinical event in pulmonary arterial hypertension trials. Methods and Results— First, to determine whether &Dgr;6MWD between baseline and 12 weeks mediated the relationship between treatment assignment and development of clinical events, we conducted a pooled analysis of patient-level data from the 10 randomized placebo-controlled trials previously submitted to the US Food and Drug Administration (n=2404 patients). Second, to identify a threshold effect for the &Dgr;6MWD that indicated a statistically significant reduction in clinical events, we conducted a meta-regression among 21 drug/dose-level combinations. &Dgr;6MWD accounted for 22.1% (95% confidence interval, 12.1%– 31.1%) of the treatment effect (P<0.001). The meta-analysis showed an average difference in &Dgr;6MWD of 22.4 m (95% confidence interval, 17.4–27.5 m), favoring active treatment over placebo. Active treatment decreased the probability of a clinical event (summary odds ratio, 0.44; 95% confidence interval, 0.33–0.57). The meta-regression revealed a significant threshold effect of 41.8 m. Conclusions— Our results suggest that &Dgr;6MWD does not explain a large proportion of the treatment effect, has only modest validity as a surrogate end point for clinical events, and may not be a sufficient surrogate end point. Further research is necessary to determine whether the threshold value of 41.8 m is valid for long-term outcomes or whether it differs among trials using background therapy or lacking placebo controls entirely.
Socioeconomic differences in outpatient healthcare utilisation are mainly seen for musculoskeletal problems in groups with poor self-rated health

Aim: To assess whether there are socioeconomic (SES) differences in outpatient visits within groups of comparable morbidity (medical disease and self-rated health) and whether psychosocial factors can explain these differences. Methods: Baseline data for SES, presence of disease, self-rated health (SRH), and psychosocial factors were collected during 2003–04 from 923 men and women aged 45–69 years in southeast Sweden. Outcome data were all registered outpatient healthcare visits to physicians during 2004–08. Cumulative incidences and standardised rate ratios (SSR) were calculated for strata of comparable morbidity for all visits, for visits due to cardiovascular disorders (CVD)/diabetes and for musculoskeletal problems. Results: Low SES was associated with more outpatient visits due to musculoskeletal problems (SRR for education 1.52, 95% CI 1.35–1.73; for occupation 1.40, 95% CI 1.26–1.56) and accentuated in groups with poor SRH. The SES effect was significant for visits to primary care and to hospitals, for men and women, and independent of present disease, SRH, and psychosocial factors. Low SES was significantly associated with more total outpatient visits at primary healthcare centres. In contrast, for outpatient visits due to CVD/diabetes, high SES was related to more visits to hospitals among people with good SRH at baseline. Conclusions: We found a consistent pattern for outpatient visits related to musculoskeletal problems where people with low SES counted more visits and this was most prominent in groups of poor SRH. The results demonstrate the need to apply different morbidity measures when studying inequalities in healthcare utilisation.
INTERPOLATION OF SUBSPACES AND APPLICATIONS TO EXPONENTIAL BASES

Precise conditions are given under which the real interpolation space (Y0 ,X 1)θ,p coincides with a closed subspace of (X0 ,X 1)θ,p when Y0 is a closed sub- space of codimension one. This result is applied to the study of nonharmonic Fourier series in the Sobolev spaces H s (−π, π )w ith 0 <s< 1. The main result looks like this: if {e iλnt } is an unconditional basis in L 2 (−π, π), then there exist two num- bers s0, s1 such that for s<s 0 the family {e iλnt } forms an unconditional basis in H s (−π, π), and for s1 <s this family forms an unconditional basis of a closed subspace in H s(−π, π) of codimension one. If s0 ≤ s ≤ s1, then the family {eiλnt} is not an unconditional basis in its span in H s(−π, π).
Autocalibration of accelerometer data for free-living physical activity assessment using local gravity and temperature: an evaluation on four continents

Wearable acceleration sensors are increasingly used for the assessment of free-living physical activity. Acceleration sensor calibration is a potential source of error. This study aims to describe and evaluate an autocalibration method to minimize calibration error using segments within the free-living records (no extra experiments needed). The autocalibration method entailed the extraction of nonmovement periods in the data, for which the measured vector magnitude should ideally be the gravitational acceleration (1 g); this property was used to derive calibration correction factors using an iterative closest-point fitting process. The reduction in calibration error was evaluated in data from four cohorts: UK (n = 921), Kuwait (n = 120), Cameroon (n = 311), and Brazil (n = 200). Our method significantly reduced calibration error in all cohorts (P < 0.01), ranging from 16.6 to 3.0 mg in the Kuwaiti cohort to 76.7 to 8.0 mg error in the Brazil cohort. Utilizing temperature sensor data resulted in a small nonsignificant additional improvement (P > 0.05). Temperature correction coefficients were highest for the z-axis, e.g., 19.6-mg offset per 5°C. Further, application of the autocalibration method had a significant impact on typical metrics used for describing human physical activity, e.g., in Brazil average wrist acceleration was 0.2 to 51% lower than uncalibrated values depending on metric selection (P < 0.01). The autocalibration method as presented helps reduce the calibration error in wearable acceleration sensor data and improves comparability of physical activity measures across study locations. Temperature ultization seems essential when temperature deviates substantially from the average temperature in the record but not for multiday summary measures.
Global root zone storage capacity from satellite-based evaporation

Abstract. This study presents an "Earth observation-based" method for estimating root zone storage capacity – a critical, yet uncertain parameter in hydrological and land surface modelling. By assuming that vegetation optimises its root zone storage capacity to bridge critical dry periods, we were able to use state-of-the-art satellite-based evaporation data computed with independent energy balance equations to derive gridded root zone storage capacity at global scale. This approach does not require soil or vegetation information, is model independent, and is in principle scale independent. In contrast to a traditional look-up table approach, our method captures the variability in root zone storage capacity within land cover types, including in rainforests where direct measurements of root depths otherwise are scarce. Implementing the estimated root zone storage capacity in the global hydrological model STEAM (Simple Terrestrial Evaporation to Atmosphere Model) improved evaporation simulation overall, and in particular during the least evaporating months in sub-humid to humid regions with moderate to high seasonality. Our results suggest that several forest types are able to create a large storage to buffer for severe droughts (with a very long return period), in contrast to, for example, savannahs and woody savannahs (medium length return period), as well as grasslands, shrublands, and croplands (very short return period). The presented method to estimate root zone storage capacity eliminates the need for poor resolution soil and rooting depth data that form a limitation for achieving progress in the global land surface modelling community.
The Journal of

The study examined the connection between writing competency and writing feedback experiences through academic writing course for student-teachers across the curriculum. The aims of the course were to prepare student-teachers to their role as writing facilitators and to improve their writing. Experimental and control group differed in course plan focused on writing feedback as the depended variable. A significant improvement was found in writing formative feedback. Interaction effect between formative feedback, writing composition and time was significant, but the expected advantage of writing feedback course was not found. This study examined feedback from the giver point of view and points at the importance of writing formative feedback among SL writers as prospective teachers but also puts some questions on the relations between writing feedback and writing competency.
Impact of body mass index on left ventricular mass.

BACKGROUND Obesity is an independent factor implicated in left ventricular (LV) hypertrophy and increased left ventricular mass. Early detection of increased LV mass in obese patients has prognostic and therapeutic implications. METHODS This case series was carried out in Choudhry Pervaiz Ellahi Institute of Cardiology, Multan from March to August 2011. A total of 100 consecutive patients including male and female referred for transthoracic echocardiography were included in this study. Patient's demographics were obtained using a questionnaire. Anthropometry (BMI) and two-dimensional echocardiography to calculate LV mass. RESULTS Echocardiograms of 100 patients showing mean age 42.42 ± 6.04 years, with BMI of 28.42 ± 5.52 and LV Mass of 136.05 ± 29.117 shown linear correlation between BMI and LV mass. CONCLUSION In is concluded from the study that LV mass increases with increasing BMI.
Solving QVIs for Image Restoration with Adaptive Constraint Sets

We consider a class of quasi-variational inequalities (QVIs) for adaptive image restoration, where the adaptivity is described via solution-dependent constraint sets. In previous work we studied both theoretical and numerical issues. While we were able to show the existence of solutions for a relatively broad class of problems, we encountered problems concerning uniqueness of the solution as well as convergence of existing algorithms for solving QVIs. In particular, it seemed that with increasing image size the growing condition number of the involved differential operator poses severe problems. In the present paper we prove uniqueness for a larger class of problems and in particular independent of the image size. Moreover, we provide a numerical algorithm with proved convergence. Experimental results support our theoretical findings.
Parathyroid Hormone Activates Mitogen-activated Protein Kinase via a cAMP-mediated Pathway Independent of Ras*

In a previous study, we demonstrated that parathyroid hormone (PTH) inhibits mitogen-activated protein (MAP) kinase activation in osteosarcoma cells via a protein kinase A-dependent pathway. Here, we show that PTH can induce a transient activation of MAP kinase as well. This was observed in both Chinese hamster ovary R15 cells stably expressing high levels of rat PTH/PTH-related peptide receptor and parietal yolk sac carcinoma cells expressing the receptor endogenously. PTH was a strong activator of adenylate cyclase and phospholipase C in Chinese hamster ovary R15 cells. PTH-induced MAP kinase activation did not depend on activation of Gi, phorbol ester-sensitive protein kinase C, elevated intracellular calcium levels, or release of Gβγ subunits. It could, however, be mimicked by addition of forskolin or 8-bromo-cAMP to these cells. Prolonged treatment with forskolin caused sustained protein kinase A activity, whereas MAP kinase activity returned to basal levels. Subsequent treatment with PTH or 8-bromo-cAMP did not result in MAP kinase activation, whereas phorbol ester- or insulin-induced MAP kinase activation was unaffected. Finally, expression of a dominant negative form of Ras (RasAsn-17), which completely blocked insulin-induced MAP kinase activation, did not affect activation by PTH or cAMP. In conclusion, PTH regulates MAP kinase activity in a cell type-specific fashion. The activation of MAP kinase by PTH is mediated by cAMP and independent of Ras.
Damped harmonic oscillator interpretation of the soft‐state power spectra of Cyg X‐1

We develop a model of an accretion disc in which the variability induced at a given radius is governed by a damped harmonic oscillator at the corresponding epicyclic frequency. That variability induces both linear and non-linear responses in the locally emitted radiation. The total observed variability of a source is the sum of these contributions over the disc radius weighted by the energy dissipation rate at each radius. It is shown that this simple model, which effectively has only three parameters including the normalization, can explain the range of the power spectra observed from Cyg X- 1 in the soft state. Although a degeneracy between the black hole mass and the strength of the damping does not allow a unique determination of the mass, we can still constrain it to ≤(16-20) M Ο . We also show that our model preserves the observed linear rms-flux relationship even in the presence of the non-linear flux response.
Dietary conjugated linoleic acid alters fatty acid composition of pig skeletal muscle and fat.

The dietary dose responsiveness of conjugated linoleic acid (CLA) addition relative to the fatty acid profile of edible lean tissue was examined in grower pigs treated with or without porcine somatotropin (pST). Gilts and barrows were fed CLA at 0, 0.25, 0.5, 1.0, or 2.0% of diet by weight from 20 to 55 kg BW. Additional pigs were administered (pST) at 0 or 100 microg x kg BW x d(-1) and fed either 0.5 or 2.0% CLA. Animals were fed diets containing 18% CP, 1.2% lysine, and 3.5 Mcal of DE/kg at 110% of ad libitum intake. The fatty acid profile in latissimus dorsi and dorsal s.c. adipose tissue samples was determined by gas chromatography. Dietary CLA replacement of corn oil increased the percentage of total fatty acids as stearic acid, whereas the percentages as oleic and linolenic acids were reduced in lattisimus muscle. Treatment with CLA + pST increased the percentages of linoleic and arachidonic acids while reducing the percentages of palmitic and oleic acids in lattisimus muscle. Dietary CLA increased the percentages of palmitic and stearic acids in s.c. adipose tissue while reducing the percentages of oleic, linoleic, linolenic, and arachidonic acids. The percentage of palmitic acid was reduced in s.c. adipose tissue, whereas linoleic acid was increased with CLA + pST. No synergistic effect was detected between CLA and pST for reducing carcass lipid content in grower pigs. However, pST increased the percentage of polyunsaturated fatty acids in lattisimus muscle and s.c. adipose tissue while reducing the percentages of saturated fatty acids in swine fed CLA.