Miracle-dz/UniFAR-FTUs huggingface dataset:
Hyperemesis gravidarum

Pregnancy-associated nausea and vomiting is a very common condition with an estimated prevalence rate ranged from 50% to 85%, but for the majority self-management suffices. The popular term “morning sickness” is a misnomer and may be minimized by obstetricians or other obstetric providers, and pregnant women, resulting in high possibility of undertreatment. Practice bulletin of the American College of Obstetricians and Gynecologists recommends that early intervention and treatment of nausea and vomiting of pregnancy is needed to prevent progression to hyperemesis gravidarum, which is characterized by persistent vomiting, weight loss of more than 5%, ketonuria, electrolyte abnormalities (hypokalemia), and dehydration (high urine specific gravity), resulting in the diminishment of the woman's quality of life and significant contribution to health care costs and time lost from work. However, hyperemesis gravidarum is a clinical diagnosis of exclusion, based on the above-mentioned typical presentation in the absence of other diseases, such as gastrointestinal conditions (e.g., appendicitis, hepatitis, pancreatitis or biliary tract disease), pyelonephritis, and metabolic disorders, such as diabetic ketoacidosis, porphyria, or Addition's disease, that could explain the finding. In addition, the presence of fever, abdominal pain, or headache is atypical in women with hyperemesis gravidarum and suggests another cause. The etiology of nausea and vomiting of pregnancy is still uncertain, and many hypotheses have been proposed, including a psychologic predisposition (a conversion or somatization disorder and inability of the woman to respond to excessive life stress), evolutionary adaptation (avoidance of toxins during pregnancy), and hormonal stimulus (human chorionic gonadotropin and estrogen); however, none of them is sufficient alone to come to diagnosis. In addition, there is no single test, which may predict when it comes to the extreme end of the spectrum of nausea and vomiting of pregnancy e hyperemesis gravidarum. Therefore, we welcome the studies investigating the relationship between markers and the presence of hyperemesis gravidarum and its severity during pregnancy. We are glad to learn that Dr. Desdidioglu's study published in this issue of the Journal of the Chinese Medical Association attempted to use the serum markers to investigate the association between these markers and pregnant women with hyperemesis gravidarum.
Phenothiazinium Antimicrobial Photosensitizers Are Substrates of Bacterial Multidrug Resistance Pumps

ABSTRACT Antimicrobial photodynamic therapy (PDT) combines a nontoxic photoactivatable dye, or photosensitizer (PS), with harmless visible light to generate singlet oxygen and free radicals that kill microbial cells. Although the light can be focused on the diseased area, the best selectivity is achieved by choosing a PS that binds and penetrates microbial cells. Cationic phenothiazinium dyes, such as methylene blue and toluidine blue O, have been studied for many years and are the only PSs used clinically for antimicrobial PDT. Multidrug resistance pumps (MDRs) are membrane-localized proteins that pump drugs out of cells and have been identified for a wide range of organisms. We asked whether phenothiazinium salts with structures that are amphipathic cations could potentially be substrates of MDRs. We used MDR-deficient mutants of Staphylococcus aureus (NorA), Escherichia coli (TolC), and Pseudomonas aeruginosa (MexAB) and found 2 to 4 logs more killing than seen with wild-type strains by use of three different phenothiazinium PSs and red light. Mutants that overexpress MDRs were protected from killing compared to the wild type. Effective antimicrobial PSs of different chemical structures showed no difference in light-mediated killing depending on MDR phenotype. Differences in uptake of phenothiazinium PS by the cells depending on level of MDR expression were found. We propose that specific MDR inhibitors could be used in combination with phenothiazinium salts to enhance their photodestructive efficiency.
Tracking the development of serum biochemical parameters in two laying hen strains - a comparative study

comparative study was designed for the description of differences between two divergent laying hen strains, a Leghorn type and a medium heavy body (MHB) genotype (Hy-Line Brown), in chemical body composition and serum biochemical parameters determined at 3, 4, 6, 8, 10, 12, 14, 18, 20, 25, 30, 52 and 72 weeks of age; each time 5 birds of both genotypes were analysed and exterminated for body composition analysis. Resulting from the genotype-associated differences, the bodyweight of the populations differed from week 20 on. In the chemical body composition dry matter content was similar, while crude protein was higher on weeks 3, 8, 10, and after 18 weeks in the Leghorns. Crude fat content was higher in the brown birds (weeks 8, 10, 25, 30). Total serum protein and albumin showed slightly increasing trends, while serum creatinine concentration showed a downward trend in both genotypes, the MHB birds having higher values. Triglyceride concentration showed a drastic step-up at 17 weeks by changing to the pre-layer diet, coupled with marked between-genotype differences. This quick increase was matched by concentration drops in total and HDL cholesterol, the serum HDL cholesterol of Leghorns being always lower. Sodium concentration showed an increasing tendency with body DM content (R 2 =0.914, P<0.001, n=115). The Leghorns tended to show minimally higher Ca concentrations. The γ-GT activity was always higher in MHB birds, indicating a less effective hepatic adaptation to the peak production. Applying discriminant analysis to classify the genotypes, 94.4% of the original grouped cases was correctly classified, using all variables.
Cognitive Function and 3-Tesla Magnetic Resonance Imaging Tractography of White Matter Hyperintensities in Elderly Persons

Background/Aims: This study used 3-Tesla magnetic resonance imaging (MRI) tractography to determine if there was an association between tracts crossing white matter hyperintensities (WMH) and cognitive function in elderly persons. Methods: Brain T2-weighted fluid-attenuated inversion recovery (FLAIR) and diffusion tensor MRI scans were acquired in participants above the age of 60 years. Twenty-six persons had WMH identified on T2 FLAIR scans. They completed a battery of neuropsychological tests and were classified as normal controls (n = 15) or with Alzheimer's dementia (n = 11). Tractography was generated by the Fiber Assignment by Continuous Tracking method. All tracts that crossed WMH were segmented. The average fractional anisotropy and average mean diffusivity of these tracts were quantified. We studied the association between cognitive test scores with the average mean diffusivity and average fractional anisotropy of tracts while controlling for age, total WMH volume and diagnosis. Results: An increased mean diffusivity of tracts crossing WMH was associated with worse performance on the Wechsler Memory Scale-III Longest Span Forward (p = 0.02). There was no association between the fractional anisotropy of tracts and performance on cognitive testing. Conclusion: The mean diffusivity of tracts crossing WMH measured by tractography is a novel correlate of performance on the Wechsler Memory Scale-III Longest Span Forward in elderly persons.
Thrombospondin, a potentiator of tumor cell metastasis.

The platelet-secreted protein thrombospondin (TSP) potentiates tumor cell metastasis. Human TSP injected i.v. into mice 5 min prior to i.v. injection of T241 sarcoma cells potentiates lung tumor colony formation. Several lines of evidence suggest that the TSP-enhancing effect involves both TSP-mediated tumor cell adhesion and the host's hemostatic system: TSP potentiates the initial, rapid sequestering of tumor cells in the lung; TSP promotes the adhesion of tumor cells in vitro; the effect of TSP on tumor cell metastasis is dependent on the presence of platelets and a normal plasma clotting system, since TSP does not potentiate lung tumor colony formation in either thrombocytopenic mice or mice anticoagulated with Coumadin. Our results suggest a central role for TSP in the metastatic process.
High Fidelity Simulation Effectiveness in Nursing Students’ Transfer of Learning

Abstract Background: Members of nursing faculty are utilizing interactive teaching tools to improve nursing student’s clinical judgment; one method that has been found to be potentially effective is high fidelity simulation (HFS). The purpose of this time series design study was to determine whether undergraduate nursing students were able to transfer knowledge and skills learned from classroom lecture and a HFS clinical to the traditional clinical setting.Method: Students (n=42) were observed and rated on their ability to perform a respiratory assessment. The observations and ratings took place at the bedside, prior to a respiratory lecture, following the respiratory lecture, and following simulation clinical.Results: The findings indicated that there was a significant difference (p=0.000) in transfer of learning demonstrated over time. Conclusions: Transfer of learning was demonstrated and the use of HFS was found to be an effective learning and teaching method. Implications of results are discussed.
Reconnissance report on geotechnical and geological aspects of the 14-16 April 2016 Kumamoto earthquakes, Japan

On 16 April 2016, a moment magnitude (Mw) 7.0 earthquake struck the Island of Kyushu, Japan. Two major foreshocks (Mw 6.2 and Mw 6.0) contributed to devastation in Kumamoto City, Mashiki Town and in the mountainous areas of the Mount Aso volcanic caldera. This report summarises geotechnical and geological aspects of the earthquakes that were observed during a field investigation conducted by the NZSEE Team in collaboration with Japanese engineers and researchers. Many houses and other buildings, roads, riverbanks, and an earth dam, either on or adjacent to the surface fault rupture or projected fault trace, were severely damaged as a result of both the strong ground shaking and permanent ground displacement. In the Mount Aso volcanic caldera, traces of medium to large scale landslides and rock falls were frequently observed. A number of landslides impacted homes and infrastructure, and were reported to have killed at least 10 people out of the 69 confirmed deaths associated with the earthquake. In a few suburbs of Kumamoto City and in Mashiki Town, localised liquefaction took place, causing lateral spreading, differential settlements of the ground and riverbanks, sinking and tilting of buildings, foundation failures, cracks on roads, and disruption of water and sewage pipe networks. The overall effects from liquefaction related hazards appeared relatively minor compared to the damage caused by shaking, landslides and surface fault rupture. Based on the field survey, key findings are highlighted and recommendations to NZ engineering practice are made in the report.
Partitioned Parallel Radix Sort

Load balanced parallel radix sort solved the load imbalance problem present in parallel radix sort. Redistributing the keys in each round of radix, each processor has exactly the same number of keys, thereby reducing the overall sorting time. Load balanced radix sort is currently known the fastest internal sorting method for distributed-memory multiprocessors. However, as the computation time is balanced, the communication time emerges as the bottleneck of the overall sorting performance due to key redistribution. We present in this report a new parallel radix sorter that solves the communication problem of balanced radix sort, called partitioned parallel radix sort. The new method reduces the communication time by eliminating the redistribution steps. The keys are first sorted in a top-down fashion (left-to-right as opposed to right-to-left) by using some most significant bits. Once the keys are localized to each processor, the rest of sorting is confined within each processor, hence eliminating the need for global redistribution of keys. It enables well balanced communication and computation across processors. The proposed method has been implemented in three different distributedmemory platforms, including IBM SP2, CRAY T3E, and PC Cluster. Experimental results with various key distributions indicate that partitioned parallel radix sort indeed shows significant improvements over balanced radix sort. IBM SP2 shows 13% to 30% improvement while Cray/SGIT3E does 20% to 100% in execution time. PC cluster shows over 2.5 fold improvement in execution time.
Influence of dietary total sulfur amino acids and methionine on growth performance and carcass characteristics of finishing gilts.

We conducted three experiments to determine the sulfur amino acid (SAA) and methionine requirements of finishing gilts. Gilts (PIC Line 326 x C-15, Exp. 1; Line 326 x C-22, Exp. 2 and 3) were blocked by initial weight in randomized complete block designs. In Exp. 1, 64 gilts (initially 54 kg) were fed diets containing either . 56 or . 44% apparent digestible lysine with increasing SAA levels (63, 70, and 77% of apparent digestible lysine) in a 2 x 3 factorial. A lysine x SAA interaction (P < .10) was observed for ADG and ADFI. Increasing SAA:lysine ratios from 63 to 70% in diets containing . 56% apparent digestible lysine increased ADG and ADFI; however, increasing the SAA:lysine ratio in diets containing . 44% apparent digestible lysine decreased ADG and ADFI. Pigs fed . 56% apparent digestible lysine had higher (P < .05) ADG and gain:feed ratio (G/F) and lower 10th rib fat depth than pigs fed . 44% apparent digestible lysine. Increasing the SAA:lysine ratio had no effect on G/F or carcass characteristics. In Exp. 2, 80 gilts (initially 74 kg) were fed diets containing . 225, . 25, . 275, . 30, or . 325% apparent digestible SAA (45, 50, 55, 60, or 65% of .50% apparent digestible lysine, respectively). Increasing SAA concentrations decreased ADG and G/F (linear, P < .06). In Exp. 3, 105 gilts (initially 72 kg) were fed diets containing . 20% apparent digestible cystine and . 10, . 125, or . 15% apparent digestible methionine (20, 25, or 30% of .50% apparent digestible lysine). Increasing digestible methionine increased ADG, ADFI, plasma methionine concentrations (linear, P < .01), and G/F (quadratic, P < .03). The greatest increases in ADG and G/F were observed when apparent digestible methionine was increased from . 10 to . 125%. Based on these results, the apparent digestible methionine requirement is no greater than 25% of apparent digestible lysine, in diets containing excess cystine. This equates to an apparent digestible SAA:lysine ratio that is no greater than 50%.
Duration of periconceptional folic acid supplementation in women booking for antenatal care

Objective: To provide accurate estimates of the commencement time, duration and dosage of folic acid (FA) supplementation taken by Irish women in the periconceptional period. The study also aimed to establish the factors associated with optimal FA supplementation practices. Design: Cross-sectional observational study. Women ’ s clinical and sociodemo-graphic details were computerised. Maternal weight and height were measured before calculating BMI. Detailed FA supplementation questionnaires were completed under the supervision of a trained researcher.
Percutaneous Drainage and Povidone-Iodine Sclerotherapy of Cervical Lymphatic Malformation

Lymphatic malformations in cases with macrocystic lesions can be treated with surgical excision or sclerotherapy using alcohol, bleomycin, doxycycline, or OK-432. We report a case of a 24-year-old woman who underwent percutaneous drainage and povidone-iodine sclerotherapy as primary treatment for cervical lymphatic malformation. The patient underwent povidone-iodine sclerotherapy for 3 consecutive days. After 8 months, ultrasonography of the lesion in the neck revealed complete resolution of the cervical lymphatic malformation without any complication. Povidone-iodine sclerotherapy can be a safe and cost-effective treatment option for cervical lymphatic malformation.
Consumer behaviour: evolution of preferences and the search for novelty

Evolution of consumers' preferences has been recognized by many scholars as being key to understanding technological change. However, mainstream economics cannot account for the seemingly irrational behavior of consumers based on changes in taste – consumer theory lacks exibility and accuracy to explain changes in consumer behavior. Adopting a behavioral psychology perspective, this paper argues that there is a rational pattern in the change of consumers' tastes. I argue that behavioral psychology offers us a unique perspective to solve some of the paradoxes of consumer behavior. This paper incorporates exibility into CES utility function to more adequately account for, and differentiate between, habit formation routines. A model is developed in which habit formation and consumption of new goods are interrelated.
Lifting GIS Maps into Strong Geometric Context

Contextual information can have a substantial impact on the performance of visual tasks such as semantic segmentation, object detection, and geometric estimation. Data stored in Geographic Information Systems (GIS) offers a rich source of contextual information that has been largely untapped by computer vision. We propose to leverage such information for scene understanding by combining GIS resources with large sets of unorganized photographs using Structure from Motion (SfM) techniques. We present a pipeline to quickly generate strong 3D geometric priors from 2D GIS data using SfM models aligned with minimal user input. Given an image resectioned against this model, we generate robust predictions of depth, surface normals, and semantic labels. We show that the precision of the predicted geometry is substantially more accurate other single-image depth estimation methods. We then demonstrate the utility of these contextual constraints for rescoring pedestrian detections, and use these GIS contextual features alongside object detection score maps to improve a CRF-based semantic segmentation framework, boosting accuracy over baseline models.
Clinical Investigation of the Protective Effects of Palm Vitamin E Tocotrienols on Brain White Matter

Background and Purpose— Previous cell-based and animal studies showed mixed tocotrienols are neuroprotective, but the effect is yet to be proven in humans. Thus, the present study aimed to evaluate the protective activity of mixed tocotrienols in humans with white matter lesions (WMLs). WMLs are regarded as manifestations of cerebral small vessel disease, reflecting varying degrees of neurodegeneration and tissue damage with potential as a surrogate end point in clinical trials. Methods— A total of 121 volunteers aged ≥35 years with cardiovascular risk factors and MRI-confirmed WMLs were randomized to receive 200 mg mixed tocotrienols or placebo twice a day for 2 years. The WML volumes were measured from MRI images taken at baseline, 1 year, and 2 years using a validated software and were compared. Fasting blood samples were collected for full blood chemistry investigation. Results— According to per-protocol (88 volunteers) and intention-to-treat (121 volunteers) analyses, the mean WML volume of the placebo group increased after 2 years, whereas that of the tocotrienol-supplemented group remained essentially unchanged. The mean WML volume change between the 2 groups was not significantly different (P=0.150) at the end of 1 year but was significant at the end of 2 years for both per-protocol and intention-to-treat analyses (P=0.019 and P=0.018). No significant difference was observed in the blood chemistry parameters between the 2 groups. Conclusions— Mixed tocotrienols were found to attenuate the progression of WMLs. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT00753532.
Reducing ventilator-associated pneumonia in intensive care: Impact of implementing a care bundle*

Objectives:Ventilator-associated pneumonia is the most common intensive care unit-acquired infection. Although there is widespread consensus that evidenced-based interventions reduce the risk of ventilator-associated pneumonia, controversy has surrounded the importance of implementing them as a “bundle” of care. This study aimed to determine the effects of implementing such a bundle while controlling for potential confounding variables seen in similar studies. Design:A before-and-after study conducted within the context of an existing, independent, infection surveillance program. Setting:An 18-bed, mixed medical–surgical teaching hospital intensive care unit. Patients:All patients admitted to intensive care for 48 hrs or more during the periods before and after intervention. Interventions:A four-element ventilator-associated pneumonia prevention bundle, consisting of head-of-bed elevation, oral chlorhexidine gel, sedation holds, and a weaning protocol implemented as part of the Scottish Patient Safety Program using Institute of Health Care Improvement methods. Measurements and Main Results:Compliance with head-of-bed elevation and chlorhexidine gel were 95%–100%; documented compliance with “wake and wean” elements was 70%, giving overall bundle compliance rates of 70%. Compared to the preintervention period, there was a significant reduction in ventilator-associated pneumonia in the postintervention period (32 cases per 1,000 ventilator days to 12 cases per 1,000 ventilator days; p < .001). Statistical process control charts showed the decrease was most marked after bundle implementation. Patient cohorts staying ≥6 and ≥14 days had greater reduction in ventilator-associated pneumonia acquisition and also had reduced antibiotic use (reduced by 1 and 3 days; p = .008/.007, respectively). Rates of methicillin-resistant Staphylococcus aureus acquisition also decreased (10% to 3.6%; p < .001). Conclusions:Implementation of a ventilator-associated pneumonia prevention bundle was associated with a statistically significant reduction in ventilator-associated pneumonia, which had not been achieved with earlier ad hoc ventilator-associated pneumonia prevention guidelines in our unit. This occurred despite an inability to meet bundle compliance targets of 95% for all elements. Our data support the systematic approach to achieving high rates of process compliance and suggest systematic introduction can decrease both infection incidence and antibiotic use, especially for patients requiring longer duration of ventilation.
Surveillance of Hospital Contacts among Danish Seafarers and Fishermen with Focus on Skin and Infectious Diseases—A Population-Based Cohort Study

Objectives: A systematic overview of time trends in hospital contacts among Danish seafarers and fishermen by job title and analyses on skin and infectious diseases. Methods: Occupational cohorts with hospital contacts 1994–1998 and 1999–2003. Standardized hospital contact ratios (SHCR) were estimated using national rates and ranked by SHCR size. Results: For non-officers in 1994–1998, infectious diseases had the highest SHCR, followed by neoplastic and endocrinal diseases; in 1999–2003 skin diseases were followed by endocrinal and gastrointestinal diseases. For fishermen in 1994–1998, nervous system, gastrointestinal, and skin diseases had the highest SHCRs; in 1999–2003 it was nervous system, skin, and lymphohematopoietic diseases. As for skin diseases, male fishermen and non-officer seamen generally had increased SHCRs, but engine room personnel specifically had a low SHCR for eczema (eight cases). Fishermen had high SHCRs for tuberculosis in both time periods (six and nine cases, respectively). Non-officer seamen on cargo ships had increased SHCRs for HIV in both time periods and for hepatitis in 1994–1999. Extending the follow-up until 2000 or 2005 showed similar results. Conclusions: Surveillance of seamen’s health gives useful information. The elevated SHCR for HIV infection among non-officers has not declined despite preventive information campaigns. Tuberculosis among fishermen may be due to infection on shore. Skin diseases had very high SHCRs, not due to cutaneous oil exposure.