Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Influencing the Preservation of the Periimplant Marginal Bone

Esthetic outcomes cannot be attributed to a single parameter. Rather, as this article shows, they are the result of a number of important factors, especially in the esthetic zone. An understanding of the meaning of biologic width, of the integration of the platform-switching concept into implant treatment facilitates the preservation of a stable marginal bone level around the implant neck. This stable bone then serves to support the soft tissue, determining the long-term esthetic and functional treatment outcomes stability. The following points should be noted: (1) A prefabricated post that can be used both as a temporary post and as the definitive abutment helps to avoid a frequent replacement of secondary components, provided that the 3-dimensional position of the implant is correct. It prevents a repeated destruction of the connective-tissue attachment on the biologic width, which would carry with it the risk of bone resorption. (2) A special implant and abutment design (a ledge and integration of the biologic width/tapered shape of the post) facilitates nonsurgical lengthening and thickening of the periimplant soft tissue. This leads to the establishment of a wider and more resistant zone of connective tissue. (3) A microrough and nanorough titanium surface extending to the implant shoulder in conjunction with the platform-switching concept provides osseous integration along the entire length of the implant. A fine thread optimally distributes the masticatory forces in the region of the implant neck, avoiding further bone loss in this region.
The Genomic Distribution and Function of Histone Variant HTZ-1 during C. elegans Embryogenesis

In all eukaryotes, histone variants are incorporated into a subset of nucleosomes to create functionally specialized regions of chromatin. One such variant, H2A.Z, replaces histone H2A and is required for development and viability in all animals tested to date. However, the function of H2A.Z in development remains unclear. Here, we use ChIP-chip, genetic mutation, RNAi, and immunofluorescence microscopy to interrogate the function of H2A.Z (HTZ-1) during embryogenesis in Caenorhabditis elegans, a key model of metazoan development. We find that HTZ-1 is expressed in every cell of the developing embryo and is essential for normal development. The sites of HTZ-1 incorporation during embryogenesis reveal a genome wrought by developmental processes. HTZ-1 is incorporated upstream of 23% of C. elegans genes. While these genes tend to be required for development and occupied by RNA polymerase II, HTZ-1 incorporation does not specify a stereotypic transcription program. The data also provide evidence for unexpectedly widespread independent regulation of genes within operons during development; in 37% of operons, HTZ-1 is incorporated upstream of internally encoded genes. Fewer sites of HTZ-1 incorporation occur on the X chromosome relative to autosomes, which our data suggest is due to a paucity of developmentally important genes on X, rather than a direct function for HTZ-1 in dosage compensation. Our experiments indicate that HTZ-1 functions in establishing or maintaining an essential chromatin state at promoters regulated dynamically during C. elegans embryogenesis.
Impacts of distributed generation on power system transient stability

It is expected that increasing amounts of new generation technologies will be connected to electrical power systems in the near future. Most of these technologies are of considerably smaller scale than conventional synchronous generators and are therefore connected to distribution grids. Further, many are based on technologies different from the synchronous generator, such as the squirrel cage induction generator and high or low speed generators that are grid coupled through a power electronic converter. When connected in small amounts, the impact of distributed generation on power system transient stability will be negligible. However, if its penetration level becomes higher, distributed generation may start to influence the dynamic behavior of the power system as a whole. In this paper, the impact of distributed generation technology and penetration level on the dynamics of a test system is investigated. It is found that the effects of distributed generation on the dynamics of a power system strongly depend on the technology of the distributed generators.
Biological models and genes of tumor reversion: Cellular reprogramming through tpt1/TCTP and SIAH-1

Tumor reversion is the process by which some cancer cells lose their malignant phenotype. This study was aimed at defining some of the molecular and phenotypic properties of this process. Biological models of tumor reversion were isolated from human leukemia and breast cancer cell lines by using the H-1 parvovirus as a selective agent. Differential gene expression analysis was performed between the parental malignant cells and their revertants or alternatively between these parental cells and their SIAH-1 transfectant counterparts. These SIAH-1 transfectants have a suppressed malignant phenotype and were used as a control for a viral-free system. Two hundred sixty-three genes were found to be either activated or inhibited during the reversion process, as confirmed by Northern blot analysis or quantitative PCR. Of these, 32% were differentially expressed in all systems, irrespective of whether parvovirus-selected, SIAH-1 overexpressing, or p53 mutant or wild-type cell lines were used, suggesting the existence of a universal mechanism underlying tumor reversion. Translationally Controlled Tumor Protein (tpt1/TCTP) has the strongest differential expression, down-regulated in the reversion of U937- and SIAH-1-overexpressing cells. Inhibition of TCTP expression by anti-sense cDNA or small interfering RNA molecules results in suppression of the malignant phenotype and in cellular reorganization, similar to the effect of SIAH-1. Hence, tumor reversion can be defined at the molecular level, not just as the reversal of malignant transformation, but as a biological process in its own right involving a cellular reprogramming mechanism, overriding genetic changes in cancer, by triggering an alternative pathway leading to suppression of tumorigenicity.
Brain Magnetic Resonance Imaging Findings Fail to Suspect Fabry Disease in Young Patients With an Acute Cerebrovascular Event

Background and Purpose— Fabry disease (FD) may cause stroke and is reportedly associated with typical brain findings on magnetic resonance imaging (MRI). In a large group of young patients with an acute cerebrovascular event, we wanted to test whether brain MRI findings can serve to suggest the presence of FD. Methods— The Stroke in Young Fabry Patients (SIFAP 1) study prospectively collected clinical, laboratory, and radiological data of 5023 patients (18–55 years) with an acute cerebrovascular event. Their MRI was interpreted centrally and blinded to all other information. Biochemical findings and genetic testing served to diagnose FD in 45 (0.9%) patients. We compared the imaging findings between FD and non-FD patients in patients with at least a T2-weighted MRI of good quality. Results— A total of 3203 (63.8%) patients had the required MRI data set. Among those were 34 patients with a diagnosis of FD (1.1%), which was definite in 21 and probable in 13 cases. The median age of patients with FD was slightly lower (45 versus 46 years) and women prevailed (70.6% versus 40.7%; P<0.001). Presence or extent of white matter hyperintensities, infarct localization, vertebrobasilar artery dilatation, T1-signal hyperintensity of the pulvinar thalami, or any other MRI finding did not distinguish patients with FD from non-FD cerebrovascular event patients. Pulvinar hyperintensity was not present in a single patient with FD but seen in 6 non-FD patients. Conclusions— Brain MRI findings cannot serve to suspect FD in young patients presenting with an acute cerebrovascular event. This deserves consideration in the search for possible causes of young patients with stroke. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT00414583.
Free Vibration Analysis of Generally Layered Composite Beams with Arbitrary Boundary Conditions

A hyperbolic shear deformation theory is used for the free vibration analysis of generally layered composite beams with arbitrary boundary conditions. The variationally consistent governing differential equations and boundary conditions are derived by employing Hamilton's principle. The dynamic stiffness method is applied to calculate the vibration frequencies of the laminated beams with the help of Wittrick–Williams algorithm. Examples of application of the hyperbolic shear deformation theory for the free vibration analysis of the laminated beams with a couple of different boundary conditions are presented. The present results are compared to the numerical solutions and experimental results available in the literature.
Isometric and isokinetic torque curves at the knee joint.

Isometric and isokinetic torques of bilateral quadriceps and hamstrings were measured with Isokinetic Rehabilitation and Testing System (Model No. Cybex 340) on 40 normal untrained subjects, 20 males and 20 females, ranging between the ages of 23 and 35 years. The mean peak isometric and isokinetic torque values of both muscle groups showed no significant differences between dominant (right) and nondominant (left) limbs in both sexes; however there were significant differences between the male and the female. As the angular velocity increased, the peak torque significantly decreased, and the point of peak torque output occurred significantly later in the range of motion for quadriceps and hamstrings (p less than 0.01). There were no significant changes in the hamstrings to quadriceps (H/Q) ratios as the angular velocity increased. However, there were significant differences of mean H/Q ratio between male and female (p less than 0.01). Height had significant positive correlation with peak isometric and isokinetic torques for both quadriceps and hamstrings (p less than 0.01). Weight was found to correlate significantly with peak isometric and isokinetic torques (p less than 0.01). The mean isometric torques were significantly higher than the mean isokinetic torques for any joint angles in both sexes (p less than .01).
Microcirculatory pathways and blood flow in spleen: new insights from washout kinetics, corrosion casts, and quantitative intravital videomicroscopy.

The dynamics of splenic microcirculatory blood flow and the role of the spleen with respect to red blood cells (RBCs) have been elucidated by means of several different experimental approaches. First, the organ was treated as a 'black box' and input/output relationships were studied, such as the kinetics of RBC and plasma washout during Ringer perfusion. Second, microcorrosion casts were prepared from minimal amounts of injected material, such that 'fast' pathways for flow were selectively identified. Third, high-resolution video-microscopy was carried out in rat and mouse spleens transilluminated in vivo, with subsequent quantitative analysis of the data. New insights were obtained regarding fast and slow pathways for RBC flow; the origin of the high intrasplenic hematocrit; immature RBCs and the spleen; the pH, O2 tension and glucose concentration within the reticular meshwork; microcirculatory pathways bordering the white pulp; entry of blood into venous sinuses, both by open ends in the marginal sinus/zone and via interendothelial slits in sinus walls; spontaneous cyclic contractions of capillary walls in vivo, impeding RBC flow (i.e. endothelial contractility); and leukocyte interactions with walls of venous vessels. The different experimental approaches have provided complementary information and have clarified a number of important issues about which uncertainty existed in the literature. Exploiting the quantitative analysis of high-resolution intravital videomicroscopic recordings has an exciting potential for gaining new insights into the workings of this complex and neglected organ.
PROJECT SELECTION BY USING FUZZY AHP AND TOPSIS TECHNIQUE

In this article, by using fuzzy AHP and TOPSIS technique we propose a new method for project selection problem. After reviewing four common methods of comparing alternatives investment (net present value, rate of return, benefit cost analysis and payback period) we use them as criteria in AHP tree. In this methodology by utilizing improved Analytical Hierarchy Process by Fuzzy set theory, first we try to calculate weight of each criterion. Then by implementing TOPSIS algorithm, assessment of projects has been done. Obtained results have been tested in a numerical example.
A Possible Function of Entamoeba histolytica in the Creation Model

Parasitology is the study of the symbiotic interaction between two different species of organisms in which one (parasite) lives in or on the other (host) and is metabolically dependent upon it. This large field includes the study of community and microbial ecology. Man and animals provide the ecological niches parasites inhabit and other organisms (for example, symbionts) they encounter. There is a need for parasites such as Entamoeba histolytica to be addressed from a biblical perspective that may include their original symbiotic or mutualistic association in man. E. histolytica is a protozoan parasite of the family Entamoebae that is found throughout the world killing approximately 100,000 people per year. Eight amoebas (Endolimax nana, Entamoeba coli, E. histolytica, E. dispar, E. hartmanni, Iodamoeba butschlii, E. moshkovskii and E. polecki) reside in the human intestinal lumen. In the pre-fallen world there was true ecological harmony with an intimate association of individuals of different species (symbiosis). Creation microbiologists are currently investigating the role of single-celled eukaryotic creatures in the organosubstrate model. While the controlling factors that direct invasiveness of E. histolytica are not well understood, the progression from originally free-living single-celled eukaryotes (neutral or beneficial) toward a pathogenic condition after the Fall could have occurred through a number of mechanisms leading to a parasitic condition.
Microbial Tyrosinases: Promising Enzymes for Pharmaceutical, Food Bioprocessing, and Environmental Industry

Tyrosinase is a natural enzyme and is often purified to only a low degree and it is involved in a variety of functions which mainly catalyse the o-hydroxylation of monophenols into their corresponding o-diphenols and the oxidation of o-diphenols to o-quinones using molecular oxygen, which then polymerizes to form brown or black pigments. The synthesis of o-diphenols is a potentially valuable catalytic ability and thus tyrosinase has attracted a lot of attention with respect to industrial applications. In environmental technology it is used for the detoxification of phenol-containing wastewaters and contaminated soils, as biosensors for phenol monitoring, and for the production of L-DOPA in pharmaceutical industries, and is also used in cosmetic and food industries as important catalytic enzyme. Melanin pigment synthesized by tyrosinase has found applications for protection against radiation cation exchangers, drug carriers, antioxidants, antiviral agents, or immunogen. The recombinant V. spinosum tryosinase protein can be used to produce tailor-made melanin and other polyphenolic materials using various phenols and catechols as starting materials. This review compiles the recent data on biochemical and molecular properties of microbial tyrosinases, underlining their importance in the industrial use of these enzymes. After that, their most promising applications in pharmaceutical, food processing, and environmental fields are presented.
Modeling and predicting personal information dissemination behavior

In this paper, we propose a new way to automatically model and predict human behavior of receiving and disseminating information by analyzing the contact and content of personal communications. A personal profile, called CommunityNet, is established for each individual based on a novel algorithm incorporating contact, content, and time information simultaneously. It can be used for personal social capital management. Clusters of CommunityNets provide a view of informal networks for organization management. Our new algorithm is developed based on the combination of dynamic algorithms in the social network field and the semantic content classification methods in the natural language processing and machine learning literatures. We tested CommunityNets on the Enron Email corpus and report experimental results including filtering, prediction, and recommendation capabilities. We show that the personal behavior and intention are somewhat predictable based on these models. For instance, "to whom a person is going to send a specific email" can be predicted by one's personal social network and content analysis. Experimental results show the prediction accuracy of the proposed adaptive algorithm is 58% better than the social network-based predictions, and is 75% better than an aggregated model based on Latent Dirichlet Allocation with social network enhancement. Two online demo systems we developed that allow interactive exploration of CommunityNet are also discussed.
Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease

The apolipoprotein E (APOE) ε4 allele carries an increased risk of a patient developing Alzheimer's disease (AD) while the ε2 allele carries a decreased risk. We compared survival from the onset of AD in subjects with different numbers of ε4 alleles and evaluated changes in genotypic frequencies with age. Two subject groups were investigated: unrelated AD case and control subjects, and affected and unaffected members from 74 multiplex AD families. In both subject groups, survival from onset decreased with increasing onset age, was longer in women, and was unrelated to ε4 gene dose. The ε2/ε3 genotype became more common with age (p = 0.004). The ε4 allele decreased in frequency with age in all patient groups but, unexpectedly, remained unchanged in control subjects. We conclude that the progression of AD is not strongly related to ε4 gene dose, that the higher prevalence of AD in women may involve the longer survival of affected women, and that AD and death are competing risks involving APOE that change over time.
In and Out of a Daydream

In this study, the authors examined the contribution of attachment orientations to the content of daily sexual fantasies. The two partners of 48 couples independently reported on their attachment orientations and provided daily reports on relationship interactions and sexual fantasies for a period of 21 days. Results showed that attachment anxiety was associated with wishes for intimacy and representations of others as more affectionate in sexual fantasies. Conversely, avoidant attachment was associated with avoidance-related wishes and representations of the self and others as more aggressive and alienated. Negative couple interactions increased habitual attachment-related wishes and self-representations. Specifically, during days characterized by negative couple interactions (relationship-damaging behaviors), attachment anxiety was associated with portrayal of the self as more helpless and avoidant attachment was associated with the expression of more avoidant wishes and portrayal of the self as less helpless. The discussion focuses on the manifestations of attachment-related interpersonal goals in sexual fantasies.
No evidence that a range of artificial monitoring cues influence online donations to charity in an MTurk sample

Monitoring cues, such as an image of a face or pair of eyes, have been found to increase prosocial behaviour in several studies. However, other studies have found little or no support for this effect. Here, we examined whether monitoring cues affect online donations to charity while manipulating the emotion displayed, the number of watchers and the cue type. We also include as statistical controls a range of likely covariates of prosocial behaviour. Using the crowdsourcing Internet marketplace, Amazon Mechanical Turk (MTurk), 1535 participants completed our survey and were given the opportunity to donate to charity while being shown an image prime. None of the monitoring primes we tested had a significant effect on charitable giving. By contrast, the control variables of culture, age, sex and previous charity giving frequency did predict donations. This work supports the importance of cultural differences and enduring individual differences in prosocial behaviour and shows that a range of artificial monitoring cues do not reliably boost online charity donation on MTurk.
Minimum Regret Search for Single- and Multi-Task Optimization

We propose minimum regret search (MRS), a novel acquisition function for Bayesian optimization. MRS bears similarities with information-theoretic approaches such as entropy search (ES). However, while ES aims in each query at maximizing the information gain with respect to the global maximum, MRS aims at minimizing the expected simple regret of its ultimate recommendation for the optimum. While empirically ES and MRS perform similar in most of the cases, MRS produces fewer outliers with high simple regret than ES. We provide empirical results both for a synthetic single-task optimization problem as well as for a simulated multi-task robotic control problem.
Steroid Therapy in the High-Risk Neonate: Benefits and Risks

Advances in obstetric management of the high-risk pregnant patient and effective early management of respiratory distress syndrome of the newborn have resulted in increased survival of very-low-birth weight infants. The combined use of antenatal glucocorticoid therapy, exogenous surfactant replacement therapy, and new ventilation strategies, including synchronized ventilation and high-frequency oscillation ventilation, is fundamental to this improvement. Neonatal survival for infants less than 28 weeks’ gestation and less than 1,250 g at birth is approximately 78%, with up to 70% of extremely-low-birth weight infants 1,000 g or less surviving until discharge from the hospital. However, chronic lung disease (CLD) remains a significant sequela among these low-birth weight survivors. Approximately 27% of low-birth weight infants 501 to 1,500 g develop CLD (oxygen requirement at 28 days of age and/or 36 weeks’ postmenstrual age), with the highest risk (≈50%) in infants weighing less than 1,000 g at birth. Infants with CLD have longer hospital stays, suffer from frequent rehospitalizations, are at higher risk for pulmonary compromise and suboptimal growth in childhood, and manifest neurodevelopmental delay and late mortality in the first year of life. The pathogenesis of CLD in the current decade is complex and uniquely distinct from the initial description by Northway et al, who detailed the pathologic changes of lung injury, repair, and fibrosis in the lungs of larger premature infants after exposure to mechanical ventilation and increased ambient oxygen. The contemporary CLD is virtually limited to the extremely-low-birth weight infant and is characterized by an arrest of lung development and interference with alveolarization. Data have shown that pulmonary inflammation may play an important role in the early development of CLD in premature infants on mechanical ventilation. Inflammatory mediators such as cytokines, platelet-activating factor, free radicals, and others may cause lung injury as well as initiate the repair process. Corticosteroids are thought to decrease lung injury by a number of mechanisms, includCorrespondence: Endla K. Anday, MD, St. Christopher’s Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134. E-mail: endla.anday@drexel.edu CLINICAL OBSTETRICS AND GYNECOLOGY Volume 46, Number 1, 190–210 © 2003, Lippincott Williams & Wilkins, Inc.