Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of and trust in health information on the Internet: A nationwide eight-year follow-up survey

Already in its infancy, the World Wide Web was predicted to be a prime tool to promote healthier behaviors. The purpose of this paper is to compare the use of and trust in health information on the Internet during two points of time, 2001 and 2009. The target group of the study is the Finnish population aged 18–65 years. The empirical material is based on two similar postal surveys. Over the period, growth in Internet use was rapid. The results also show a huge growth in use of and trust in health information on the Internet. But still, the e-Health visions evoked in the late 1990s are far from fulfilled, since too many people seem not to seek or obtain health information from the Internet at all. Furthermore, still in 2009, approximately one-third of the respondents had no conception (‘do not know’) about the online health information reliability, due to the fact that they had used it too rarely or not at all.
Drug therapy for myelodysplastic syndrome

Myelodysplastic syndrome (MDS) is currently a consensus-based pathologic diagnosis that is determined by partly subjective findings from bone marrow histology and peripheral blood smear. Biologically, MDS constitutes a stem cell-derived, ineffective clonal myeloproliferation that results in symptomatic cytopenia and in time evolves into acute myeloid leukemia (AML). MDS is rare in persons age 50 years but might be the most common hematologic malignancy in the elderly, with an annual reported incidence of 20/100,000 after age 70 years. As such, the overwhelming majority of patients with MDS are not suitable candidates for allogeneic hematopoietic stem cell transplantation. However, insufficient knowledge regarding disease pathogenesis has restricted the development of effective drug therapy. Nevertheless, there has been some progress, capped by the recognition, in MDS, of cytokinemediated retardation of clonal myelopoiesis and epigenetic transcriptional dysregulation. Such information has fostered clinical trials with a strategy to either suppress nosogenic cytokine activity or reactivate regulatory gene expression by overcoming epigenetic gene silencing. The latter is accomplished by drug-induced demethylation of abnormally hypermethylated gene promoter regions or transcription-friendly chromatin modification by inhibition of histone deacetylase (HDAC). Abnormal DNA methylation is believed to inactivate tumor suppressor genes (eg, p15) as well as other tumor-related genes and to contribute to clonal expansion as well as disease progression in MDS. Accordingly, recent treatment approaches have focused on reactivating such silenced genes by targeting enzymes that facilitate either DNA methylation or histone deacetylation. Results from a series of Phase I, II, and III studies using DNA hypomethylating agents have provided proof of principle in terms of clinical activity, although not necessarily mechanism of action, for the former approach and on May 19, 2004, the Food and Drug Administration (FDA) approved subcutaneously administered 5-azacytidine for the treatment of symptomatic MDS. 5-aza-deoxycytidine (decitabine) is the deoxy derivative of 5-azacytidine and is a more potent inhibitor of DNA methyltransferase in vitro. Similar to the case with 5-azacytidine, encouraging results from Phase I/II studies led to a Phase III decitabine study in patients with MDS (n 170 patients), the results of which are presented in the current issue of Cancer. Compared with best supportive care, intravenous treatment with decitabine, produced a significantly better overall response rate (30% vs. 7%) and was 1650
Alleged Sex Abuse Victims' Accounts of Their Abusers' Modus Operandi

One hundred four alleged sexual victims aged between 3 and 13 years described the modus operandi of their reported assailants. Younger children were more likely than older children to report repeated incidents of abuse by family members. Abuse tended to be more severe when there were multiple incidents. Older victims were more likely to report resisting the offenders' strategies, which involved either persuasion (i.e., offering rewards, verbally convincing or provoking the victim) or coercion (i.e., verbal or physical threats). Adult suspects were reportedly more likely than young suspects to use persuasion, but there were no age of suspect differences in the reported occurrence of coercion.
Open Innovation and Control: A Case from Volvo

The concept of open innovation has gained wide-spread attention in different research communities. Nevertheless, it is based on a relatively thin theoretical base dominated by aspects of organizational and intellectual property strategies. Building upon a longitudinal case study, this paper provides an example of open innovation from the Volvo Group. The vehicle manufacturer joined forces for inter-organizational collaboration with a telecommunication operator and a telecommunication infrastructure provider in order to nurture the innovation of vehicle services. Ten years since its formation, this study provides an interpretation in terms of open innovation and illuminates several implications. By focusing the case on IT aspects, we show how the chosen system approach inscribes a high level of control that does not nurture distribution of new vehicle services among other stakeholders. The paper contributes to nuance the understanding of open innovation and in particular demonstrates the role of IT.
The Decline of Remarriage: Evidence From German Village Populations in the Eighteenth and Nineteenth Centuries

Family reconstitution data for fourteen German village populations permit the examination of remarriage during the eighteenth and nineteenth cen turies. The results provide compelling evidence for a secular decline in the tenden cy to remarry. Pronounced age and sex differentials in the likelihood of remar riage were evident: widows were far less likely to remarry than widowers, and the probability of remarriage declined rapidly with age, particularly for women. The probability of remarriage was also inversely associated with the number and age of children. There were, however, no clear differences in either the probability of remarriage or its tendency to decline over time among major occupational groups. The decline in remarriage probabilities was caused in part by declines in adult mortality, which gradually raised the ages of surviving spouses to levels at which remarriage has historically been rather unlikely. However, age-specific marriage probabilities also declined, affecting both men and women and all oc cupational groups, suggesting the presence of a social change of wide scope. Some comments on possible factors contributing to the decline of remarriage are presented. The need for a comprehensive explanation of remarriage trends and differentials remains an important challenge for family historians.
Clopidogrel: an updated and comprehensive review

The risk of adverse events in patients with acute coronary syndrome remains substantial despite the use of regular aspirin. The addition of clopidogrel to regular aspirin therapy has been shown to be associated with significantly better outcomes in a variety of clinical settings within the spectrum of acute coronary syndromes. In this article, the evidence and therapeutic implications for the use of clopidogrel in patients with non-ST-elevation and ST elevation acute coronary syndromes is discussed, and also in those undergoing percutaneous coronary intervention. The use of clopidogrel in combination with other antithrombotics in the acute setting is considered, including glycoprotein IIb/IIIa receptor antagonists and direct thrombin inhibitors. Clopidogrel has changed the way in which patients with non-ST-elevation and, more recently, ST elevation acute coronary syndromes are treated.
Comparison of postoperative outcomes among patients treated by male and female surgeons: a population based matched cohort study

Objective To examine the effect of surgeon sex on postoperative outcomes of patients undergoing common surgical procedures. Design Population based, retrospective, matched cohort study from 2007 to 2015. Setting Population based cohort of all patients treated in Ontario, Canada. Participants Patients undergoing one of 25 surgical procedures performed by a female surgeon were matched by patient age, patient sex, comorbidity, surgeon volume, surgeon age, and hospital to patients undergoing the same operation by a male surgeon. Interventions Sex of treating surgeon. Main outcome measure The primary outcome was a composite of death, readmission, and complications. We compared outcomes between groups using generalised estimating equations. Results 104 630 patients were treated by 3314 surgeons, 774 female and 2540 male. Before matching, patients treated by female doctors were more likely to be female and younger but had similar comorbidity, income, rurality, and year of surgery. After matching, the groups were comparable. Fewer patients treated by female surgeons died, were readmitted to hospital, or had complications within 30 days (5810 of 52 315, 11.1%, 95% confidence interval 10.9% to 11.4%) than those treated by male surgeons (6046 of 52 315, 11.6%, 11.3% to 11.8%; adjusted odds ratio 0.96, 0.92 to 0.99, P=0.02). Patients treated by female surgeons were less likely to die within 30 days (adjusted odds ratio 0.88; 0.79 to 0.99, P=0.04), but there was no significant difference in readmissions or complications. Stratified analyses by patient, physician, and hospital characteristics did not significant modify the effect of surgeon sex on outcome. A retrospective analysis showed no difference in outcomes by surgeon sex in patients who had emergency surgery, where patients do not usually choose their surgeon. Conclusions After accounting for patient, surgeon, and hospital characteristics, patients treated by female surgeons had a small but statistically significant decrease in 30 day mortality and similar surgical outcomes (length of stay, complications, and readmission), compared with those treated by male surgeons. These findings support the need for further examination of the surgical outcomes and mechanisms related to physicians and the underlying processes and patterns of care to improve mortality, complications, and readmissions for all patients.
Who gets left behind? The fate of the unrepresented in the wake of US–India higher education partnerships

The promotion of US–Indian higher education partnerships affects those students who are most marginalized. This article explores the development, implementation, and reception of such partnerships to meet the needs of students who remain on the borders of educational access in India. This article addresses the ways higher education policies systematically universalize the marginalization of certain students, explores the impact of how policies of partnerships will address the needs of such students, and seeks to explore how administrators in higher education institutions see the growth of such partnerships shifting the status quo of privilege and power. Through the evaluation of policy papers, historical documents, media reports, survey data and informal conversations with stakeholders, the findings will address the underlying consequences and effects on higher education policy development in India. This article seeks to deconstruct the directions such relationships might take and consider the impact on students who remain on the periphery of higher education in India.
The Reliability and Validity of the Lasater Clinical Judgement Rubric in Korean Nursing Students

Purpose: This study was done to evaluate the Lasater Clinical Judgement Rubric for use with Korean nursing students. Methods: A methodological study was used to validate the rubric developed by Lasater to assess clinical judgment during nursing simulation. Participants were 34 nursing students at K University in Seoul. Between February and May, 2012, analysis was done of 91 video clips recording performance during simulation. Results: Findings showed reliability and validity of the rubric. For internal consistency, Cronbach‘s α score was . 884 and intraclass correlation coefficient was . 839, which established reliability. The rubric was validated using the exploratory factor analysis and content validity. The content validity score was 83%, establishing the appropriateness and readiness of the tool. Factor analysis showed that noticing, responding, and reflecting domains had Eigen values of 2.669, 1.991, and 2.912, respectively and were bound, but unlike the original tool in which four factors noticing, interpretation, responding, and reflecting domains were bound. Conclusion: Results of the study indicate that the rubric shows acceptable reliability and validity in Korean nursing students. This evaluation tool for nursing simulation allows nursing faculty to objectively evaluate students’ clinical judgment as well as students to reflect on their clinical judgment process during simulation.
Resiliencism: premises and promises in securitisation research

In the past decade, a great deal has been written in the scholarly literature about the role of resilience in our social world. This scholarship has sparked vivid theoretical debates in psychology, criminology, social work and political geography about the nature of resilience and how scholars should go about studying it. Yet, International Relations and security studies have been relatively absent from the vibrant discussion. The term is employed but rarely unpacked, let alone theoretically analysed. This article outlines some necessary steps of convergence, enabling a coherent framework for a resiliencist approach to the study of the securitisation process. The bulk of the article lays out the premises of resiliencism, discusses the added value of the approach, suggests distinguishing between three types of resilience and illustrates the set of arguments with the case of the securitisation of migration in France and in Canada.
Diffusive Molecular Communication with Nanomachine Mobility

This work presents a performance analysis for diffusive molecular communication with mobile transmit and receive nanomachines. To begin with, the optimal test is obtained for symbol detection at the receiver nanomachine. Subsequently, closed-form expressions are derived for the probabilities of detection and false alarm, probability of error, and capacity considering also aberrations such as multi-source interference, inter-symbol interference, and counting errors. Simulation results are presented to corroborate the theoretical results derived and also, to yield various insights into the performance of the system. Interestingly, it is shown that the performance of the mobile diffusive molecular communication can be significantly enhanced by allocating large fraction of total available molecules for transmission as the slot interval increases.
PRMT8, a New Membrane-bound Tissue-specific Member of the Protein Arginine Methyltransferase Family*

Protein arginine methylation is a common post-translational modification that has been implicated in signal transduction, RNA processing, transcriptional regulation, and DNA repair. A search of the human genome for additional members of the protein arginine N-methyltransferase (PRMT) family of enzymes has identified a gene on chromosome 12 that we have termed PRMT8. This novel enzyme is most closely related to PRMT1, although it has a distinctive N-terminal region. The unique N-terminal end harbors a myristoylation motif, and we have shown here that PRMT8 is indeed modified by the attachment of a myristate to the glycine residue after the initiator methionine. The myristoylation of PRMT8 results in its association with the plasma membrane. The second singular property of PRMT8 is its tissue-specific expression pattern; it is largely expressed in the brain. A glutathione S-transferase fusion protein of PRMT8 has type I PRMT activity, catalyzing the formation of ω-NG-monomethylated and asymmetrically ω-NG,NG-dimethylated arginine residues on a recombinant glycine- and arginine-rich substrate. PRMT8 is thus an active arginine methyltransferase that is membrane-associated and tissue-specific, two firsts for this family of enzymes.
Stabilization of Stochastic Quantum Dynamics via Open- and Closed-Loop Control

In this paper, we investigate parametrization-free solutions of the problem of quantum pure state preparation and subspace stabilization by means of Hamiltonian control, continuous measurement, and quantum feedback, in the presence of a Markovian environment. In particular, we show that whenever suitable dissipative effects are induced either by the unmonitored environment, or by non-Hermitian measurements, there is no need for feedback, as open-loop time-invariant control is sufficient to achieve stabilization of the target set in probability. Constructive necessary and sufficient conditions on the form of the control Hamiltonian can be provided in this case. When time-invariant control is not sufficient, state stabilization can be attained by the addition of filtering-based feedback control.
The Language Portfolio as a Self-Assessment Mechanism in an English Course Aimed at Fostering Senior Students’ Autonomy

This article describes an action research project in which the members of a basic English class for adults over 50 at a Colombian public university undertook the mission of discovering their potentialities as autonomous learners. By means of the reflective use of the language portfolio, the members of this course guided the planning and execution stages of the course they were enrolled in. The findings show that learners’ reflection may be convenient when designing a course that better fits the characteristics, needs, and expectations of the students so that the they can profit more from the course itself.
Prevention of Assay Interference in Infectious-Disease Serology Tests Done on the Liaison Platform

ABSTRACT Immunoassay interference causing unexpected reactive results in magnetic-microparticle-based assays was detected. A systematic evaluation of Liaison Epstein-Barr virus immunoglobulin M showed that 5% of the positive results (0.4% of tested samples) could be explained by such interference. Adding chemical blocking reagents (polyvinylpyrrolidone and polyvinyl alcohol) to the assay buffers partially prevented this phenomenon.
Work Integrated Learning: A Guide to Effective Practice

Acknowledgements The Authors Introduction 1. The New Higher Education Enterprise 2. A Conceptual Framework For Work Integrated Learning 3. Working To Learn, Learning To Work 4. Teaching In Work Integrated Learning 5. Assessing Work Integrated Learning 6. Supervision 7. Managing Difficult Situations 8. The Work Integrated Learning Process Appendix 1: Workplace Literacies - Knowledge, Skills And Attributes Appendix 2: Specific Risks And Difficulties Encountered In The Workplace Glossary References
An Evaluation of the Binding Strength of Okra Gum and the Drug Release Characteristics of Tablets Prepared from It

The aim of this study is to evaluate the adhesion ability of okra gum, which is gaining popularity as a tablet binder. For this purpose, gum was extracted from okra pods, and the binding strength of different concentrations (1%, 3%, and 5%) was determined quantitatively. Additionally, naproxen sodium tablets were prepared by using okra gum as a binder and were evaluated for their properties including hardness, friability, disintegration time, and dissolution rate. The binding strength values were compared with that of pre-gelatinized starch, a commonly used tablet binder. The results from universal testing machine indicate that the binding strengths of all dispersions of okra increase as the concentration increases from 1% to 5% and ranges from 2.5 to 4.5 N, which are almost twice a high as those of pre-gelatinized starch. The tablets prepared with okra gum have shown good mechanical strength with hardness values of 7–8.5 kg/cm2 and a friability <1%, comparable to tablets prepared with starch. The disintegration time was longer (7.50 min with okra gum and 5.05 min with starch paste), and the drug release from these tablets was slower than the formulations with starch. The higher binding ability of okra gum probably linked with its chemical composition as it mainly contains galactose, rhamnose, and galacturonic acid. This study concludes that okra gum is a better binder than pre-gelatinized starch, it might be explored in future for introduction as a cost-effective binder in the pharmaceutical industry.
The Internet, Public Spheres, and Political Communication: Dispersion and Deliberation

The theme of the Internet and the public sphere now has a permanent place on research agendas and in intellectual inquiry; it is entering the mainstream of political communication studies. The first part of this presentation briefly pulls together key elements in the public sphere perspective, underscoring three main analytic dimensions: the structural, the representational, and the interactional. Then the discussion addresses some central themes in the current difficulties facing democracy, refracted through the lens of the public sphere perspective. In particular, the destabilization of political communication systems is seen as a context for understanding the role of the Internet: It enters into, as well as contributes to, this destabilization. At the same time, the notion of destabilization can also embody a positive sense, pointing to dispersions of older patterns that may have outlived their utility. Further, the discussion takes up obvious positive consequences that follow from the Internet, for example that it extends and pluralizes the public sphere in a number of ways. Thereafter the focus moves on to the interactional dimension of the public sphere, specifically in regard to recent research on how deliberation proceeds in the online public sphere in the contemporary environment of political communication. Finally, the analytic category of deliberative democracy is critically examined; while useful, some of its rationalist biases, particularly in the context of extra–parliamentarian politics, limit its utility. It is suggested that the concept of civic cultures offers an alternative way to understand the significance of online political discussion.
Are Special Educators' Career Paths Special? Results from a 13-Year Longitudinal Study

A statistical methodology relatively new to education—survival analysis—is used to describe the career paths of over 6,600 special education teachers newly hired in Michigan and North Carolina between 1972 and 1983, following them for up to 13 years, or until they stopped teaching in the state. Beginning special educators in both states continue to teach for an average of 7 years. They are most likely to leave teaching during the first few years after hire; those who survive this initial “hazardous” period typically teach for many years to come. Young women are particularly likely to leave, as are those special educators who provide support services or teach students with speech, hearing, or vision disabilities. Teachers with high test scores are at greater risk of leaving as are teachers paid comparatively low salaries.