Miracle-dz/UniFAR-FTUs huggingface dataset:
The effects of patient education on patient safety: can we change patient perceptions and attitudes? Lessons from the Armed Forces Capital Hospital in Korea

Objective Strategies to promote patient involvement in medical error prevention have been implemented, but little is known about the effects of education on changes in perceptions and attitudes about patients' own safety. Design We administered a survey to military personnel admitted to the Armed Forces Capital Hospital. Responses were classified according to perception and attitude. Setting Single military hospital in Korea. Participants A total of 483 completed surveys were included in our study; 252 of the respondents received safety education at admission. Methods We provided educational program material to one-half of the patients at admission (intervention group). The other one-half of patients received no safety education (non-intervention group). We then performed two rounds of a self-administered survey, based on whether the patient received patient safety education. Cronbach's alpha was calculated to determine scale score reliability. Regression analysis was used to evaluate associations between education and change in scores. Results Scores for perception and attitude were greater in the intervention group. The results of the regression analysis revealed that compared with the non-intervention respondents, the respondents who received education had higher perception (estimate: 7.809, P < 0.0001) and attitude scores (estimate: 5.539, P < 0.0001). Conclusion Our study results suggested that patient education was associated with higher scores in both perception and attitudes about safety. To improve patient engagement in this area, efficient methods that encourage patient empowerment should be developed. Specialized health care providers who provide patient level education are needed to achieve a satisfactory patient safety climate.
Identifying essential test locations for oat breeding in eastern Canada.

The oat (Avena sativa L.) breeding program at the Eastern Cereal and Oilseed Research Centre of Agriculture & Agri-Food Canada has the responsibility to breed new oat cultivars for producers in eastern Canada, which includes Ontario, Quebec, and the Atlantic provinces. A 3-yr multilocation test was conducted to understand the genotype × location interaction patterns and the relationships among test locations in eastern Canada. A genotype + genotype × environment interaction biplot analysis of yield data revealed three distinct oat mega-environments in eastern Canada: (i) northern Ontario, (ii) southern and eastern Ontario, and (iii) Quebec and Atlantic Canada. To breed for all megaenvironments, initial yield screening must be conducted at locations representing each of these mega-environments. Based on the relationships among test locations, six essential test locations were identifi ed: three in Ontario, two in Quebec, and one in Atlantic Canada. Testing at all six locations appeared to provide a good coverage of the whole oat-growing area in eastern Canada. Based on these fi ndings, a breeding and test strategy was developed. This includes conducting initial yield screening at three locations in Ontario, Quebec, and Atlantic Canada, followed by a formal yield test at all six essential test locations. Specifi cally adapted genotypes selected from this test will then be tested in the Registration Tests in their respectively adapted subregions.
Per-Contact Iteration Method for Solving Contact Dynamics

This letter introduces a new iterative method for contact dynamics problems. The proposed method is based on an efficient bisection method which iterates over each contact. We compared our approach to two existing ones for the same model and found that it is about twice as fast as the existing ones. We also introduce four different robotic simulation experiments and compare the proposed method to the most common contact solver, the projected Gauss–Seidel (PGS) method. We show that, while both methods are very efficient in solving simple problems, the proposed method significantly outperforms the PGS method in more complicated contact scenarios. Simulating one time step of an 18-DOF quadruped robot with multiple contacts took less than 20 $\mu$s with a single core of a CPU. This is at least an order of magnitude faster than many other simulators which employ multiple relaxation methods to the major dynamic principles in order to boost their computational speed. The proposed simulation method is also stable at 50 Hz due to its strict adherence to the dynamical principles. Although the accuracy might be compromised at such a low update rate, this means that we can simulate an 18-DOF robot more than thousand times faster than the real time.
Patterns of Fitbit Use and Activity Levels Throughout a Physical Activity Intervention: Exploratory Analysis from a Randomized Controlled Trial

Background There has been a rapid increase in the use of technology-based activity trackers to promote behavior change. However, little is known about how individuals use these trackers on a day-to-day basis or how tracker use relates to increasing physical activity. Objective The aims were to use minute level data collected from a Fitbit tracker throughout a physical activity intervention to examine patterns of Fitbit use and activity and their relationships with success in the intervention based on ActiGraph-measured moderate to vigorous physical activity (MVPA). Methods Participants included 42 female breast cancer survivors randomized to the physical activity intervention arm of a 12-week randomized controlled trial. The Fitbit One was worn daily throughout the 12-week intervention. ActiGraph GT3X+ accelerometer was worn for 7 days at baseline (prerandomization) and end of intervention (week 12). Self-reported frequency of looking at activity data on the Fitbit tracker and app or website was collected at week 12. Results Adherence to wearing the Fitbit was high and stable, with a mean of 88.13% of valid days over 12 weeks (SD 14.49%). Greater adherence to wearing the Fitbit was associated with greater increases in ActiGraph-measured MVPA (binteraction=0.35, P<.001). Participants averaged 182.6 minutes/week (SD 143.9) of MVPA on the Fitbit, with significant variation in MVPA over the 12 weeks (F=1.91, P=.04). The majority (68%, 27/40) of participants reported looking at their tracker or looking at the Fitbit app or website once a day or more. Changes in Actigraph-measured MVPA were associated with frequency of looking at one’s data on the tracker (b=−1.36, P=.07) but not significantly associated with frequency of looking at one’s data on the app or website (P=.36). Conclusions This is one of the first studies to explore the relationship between use of a commercially available activity tracker and success in a physical activity intervention. A deeper understanding of how individuals engage with technology-based trackers may enable us to more effectively use these types of trackers to promote behavior change. Trial Registration ClinicalTrials.gov NCT02332876; https://clinicaltrials.gov/ct2/show/NCT02332876? term=NCT02332876 &rank=1 (Archived by WebCite at http://www.webcitation.org/6wplEeg8i).
Maturation in Serum Thyroid Function Parameters Over Childhood and Puberty: Results of a Longitudinal Study

Context: Serum thyroid hormone levels differ between children and adults, but have not been studied longitudinally through childhood. Objective: To assess changes in thyroid-stimulating hormone (TSH) and thyroid hormone levels over childhood and their interrelationships. Design: Cohort study. Setting: The Avon Longitudinal Study of Parents and Children, a population-based birth cohort. Participants: A total of 4442 children who had thyroid function measured at age 7, and 1263 children who had thyroid function measured at age 15. Eight hundred eighty-four children had measurements at both ages. Main Outcome Measures: Reference ranges for TSH, free tri-iodothyronine (FT3), free thyroxine (FT4), their longitudinal stability, and interrelationships. Results: Children at age 7 years had a higher FT3 [6.17 pmol/L, standard deviation (SD) 0.62] than children at age 15 (5.83 pmol/L, SD 0.74); P < 0.0001 with 23.2% of children at age 7 having FT3 above the adult reference range. Higher FT3 levels at age 7 in boys (P = 0.0001) and girls (P = 0.04) were associated with attainment of a more advanced pubertal stage at age 13. TSH was positively associated with FT3 at age 7 and age 15 even after adjusting for confounders. In contrast, TSH was negatively associated with FT4. Conclusions: There are substantial changes in TSH and thyroid hormone levels over childhood, in particular for FT3, which appear to relate to pubertal readiness. Our data provide increased insight into the evolution of the pituitary–thyroid axis over childhood and may have implications for determining optimal ranges for thyroid hormone replacement in children.
The Optimization of an eHealth Solution (Thought Spot) with Transition-Aged Youth in Postsecondary Settings: Participatory Design Research

Background Seventy percent of lifetime cases of mental illness emerge before the age of 24 years, but many youth are unable to access the support and services they require in a timely and appropriate way. With most youth using the internet, electronic health (eHealth) interventions are promising tools for reaching this population. Through participatory design research (PDR) engagement methods, Thought Spot, a Web- and mobile-based platform, was redeveloped to facilitate access to mental health services by transition-aged youth (aged 16-29 years) in postsecondary settings. Objective The aim of this study was to describe the process of engaging with postsecondary students through the PDR approaches, with the ultimate goal of optimizing the Thought Spot platform. Methods Consistent with the PDR approaches, five student-led workshops, attended by 41 individuals, were facilitated to obtain feedback regarding the platform’s usability and functionality and its potential value in a postsecondary setting. Various creative engagement activities were delivered to gather experiences and opinions, including semistructured focus groups, questionnaires, personas, journey mapping, and a world café. Innovative technological features and refinements were also brainstormed during the workshops. Results By using PDR methods of engagement, participants knew that their ideas and recommendations would be applied. There was also an overall sense of respect and care integrated into each group, which facilitated an exchange of ideas and suggestions. Conclusions The process of engaging with students to redesign the Thought Spot platform through PDR has been effective. Findings from these workshops will significantly inform new technological features within the app to enable positive help-seeking behaviors among students. These behaviors will be further explored in the second phase that involves a randomized controlled trial.
Inflammatory stress promotes the development of obesity-related chronic kidney disease via CD36 in mice[S]

Ectopic fat located in the kidney has emerged as a novel cause of obesity-related chronic kidney disease (CKD). In this study, we aimed to investigate whether inflammatory stress promotes ectopic lipid deposition in the kidney and causes renal injury in obese mice and whether the pathological process is mediated by the fatty acid translocase, CD36. High-fat diet (HFD) feeding alone resulted in obesity, hyperlipidemia, and slight renal lipid accumulation in mice, which nevertheless had normal kidney function. HFD-fed mice with chronic inflammation had severe renal steatosis and obvious glomerular and tubular damage, which was accompanied by increased CD36 expression. Interestingly, CD36 deficiency in HFD-fed mice eliminated renal lipid accumulation and pathological changes induced by chronic inflammation. In both human mesangial cells (HMCs) and human kidney 2 (HK2) cells, inflammatory stress increased the efficiency of CD36 protein incorporation into membrane lipid rafts, promoting FFA uptake and intracellular lipid accumulation. Silencing of CD36 in vitro markedly attenuated FFA uptake, lipid accumulation, and cellular stress induced by inflammatory stress. We conclude that inflammatory stress aggravates renal injury by activation of the CD36 pathway, suggesting that this mechanism may operate in obese individuals with chronic inflammation, making them prone to CKD.
Plant Glycine-Rich Proteins in Stress Response: An Emerging, Still Prospective Story

Seed plants are sessile organisms that have developed a plethora of strategies for sensing, avoiding, and responding to stress. Several proteins, including the glycine-rich protein (GRP) superfamily, are involved in cellular stress responses and signaling. GRPs are characterized by high glycine content and the presence of conserved segments including glycine-containing structural motifs composed of repetitive amino acid residues. The general structure of this superfamily facilitates division of GRPs into five main subclasses. Although the participation of GRPs in plant stress response has been indicated in numerous model and non-model plant species, relatively little is known about the key physiological processes and molecular mechanisms in which those proteins are engaged. Class I, II, and IV members are known to be involved in hormone signaling, stress acclimation, and floral development, and are crucial for regulation of plant cells growth. GRPs of class IV [RNA-binding proteins (RBPs)] are involved in alternative splicing or regulation of transcription and stomatal movement, seed, pollen, and stamen development; their accumulation is regulated by the circadian clock. Owing to the fact that the overexpression of GRPs can confer tolerance to stress (e.g., some are involved in cold acclimation and may improve growth at low temperatures), these proteins could play a promising role in agriculture through plant genetic engineering. Consequently, isolation, cloning, characterization, and functional validation of novel GRPs expressed in response to the diverse stress conditions are expected to be growing areas of research in the coming years. According to our knowledge, this is the first comprehensive review on participation of plant GRPs in the response to diverse stress stimuli.
Diagnostic Usefulness of Varicella-Zoster Virus Real-Time Polymerase Chain Reaction Analysis of DNA in Saliva and Plasma Specimens From Patients With Herpes Zoster

Background We evaluated the diagnostic usefulness of polymerase chain reaction (PCR) analysis for detecting varicella-zoster virus (VZV) infection and reactivation of VZV, using DNA extracted from saliva and plasma specimens obtained from subjects with suspected herpes zoster and from healthy volunteers during stressful and nonstressful conditions. Methods There were 52 patients with a diagnosis of herpes zoster (group 1), 30 with a diagnosis of zoster-mimicking disease (group 2), and 27 healthy volunteers (group 3). Saliva and plasma samples were evaluated for VZV DNA by real-time PCR analysis. Results Among patients with suspected herpes zoster (ie, patients in groups 1 and 2), the sensitivity of PCR analysis of salivary DNA for detecting VZV (88%; 95% confidence interval [CI], 74%-95%) was significantly higher than that of PCR analysis of plasma DNA (28%; 95% CI, 16%-44%; P < .001), whereas the specificity of PCR analysis of salivary DNA (100%; 95% CI, 88%-100%) was similar to that of PCR analysis of plasma DNA (100%; 95% CI, 78%-100%; P > .99). VZV DNA was not detected in saliva and plasma samples from group 3 (0%; 95% CI, 0%-14%). Conclusions Real-time PCR analysis of salivary DNA is more sensitive than that of plasma DNA for detecting VZV among patients with suspected herpes zoster. We found no subclinical reactivation of VZV in group 3 following exposure to common stressful conditions.
Exceptional chemical and thermal stability of zeolitic imidazolate frameworks

Twelve zeolitic imidazolate frameworks (ZIFs; termed ZIF-1 to -12) have been synthesized as crystals by copolymerization of either Zn(II) (ZIF-1 to -4, -6 to -8, and -10 to -11) or Co(II) (ZIF-9 and -12) with imidazolate-type links. The ZIF crystal structures are based on the nets of seven distinct aluminosilicate zeolites: tetrahedral Si(Al) and the bridging O are replaced with transition metal ion and imidazolate link, respectively. In addition, one example of mixed-coordination imidazolate of Zn(II) and In(III) (ZIF-5) based on the garnet net is reported. Study of the gas adsorption and thermal and chemical stability of two prototypical members, ZIF-8 and -11, demonstrated their permanent porosity (Langmuir surface area = 1,810 m2/g), high thermal stability (up to 550°C), and remarkable chemical resistance to boiling alkaline water and organic solvents.
Synoptic Composites of the Extratropical Transition Life Cycle of North Atlantic Tropical Cyclones: Factors Determining Posttransition Evolution

Abstract A 34-member ensemble-mean trajectory through the cyclone phase space (CPS) is calculated using Navy Operational Global Atmospheric Prediction System (NOGAPS) analyses for North Atlantic tropical cyclones (TCs) undergoing extratropical transition (ET). Synoptic composites at four ET milestones are examined: 24 h prior to the beginning of ET (TB − 24), the beginning of ET (TB), the end of ET (TE), and 24 h after the end of ET (TE + 24). While the extratropically transitioning TC structure is tightly constrained in its tropical phase, it has a variety of evolutions after TE. Partitioning the ensemble based upon post-ET intensity change or structure discriminates among statistically significant ET precursor conditions. Compositing the various post-ET intensity regimes provides insight into the important environmental factors governing post-ET development. A TC that intensifies (weakens) after TE begins transition (t = TB) with a negatively (positively) tilted trough 1000 km (1500 km) upstream. The ne.
Vitamin D receptor rs2228570 polymorphism and susceptibility to ovarian cancer: An updated meta‐analysis

The FokI polymorphism (C>T, rs2228570) of the vitamin D receptor gene is a coding nonsynonymous single nucleotide polymorphism in the translational initiation codon reported to have functional significance. Although the role of rs2228570 in the risk of ovarian cancer has been widely researched, the association is still unclear. We performed an updated meta‐analysis to clarify this issue.
Approximate quasi efficient solutions in multiobjective optimization

In this paper we consider unitar concepts for some optimality and efficiency or approximate solutions in scalar optimization and vectorial optimization respectively. In this cases some necessary and/or sufficient c onditions for these approximate solutions in the multiobjective case are derived via scalarization and an alternative theorem. Thus are generalized and refined some corresponding results in multiobjective optimization.
High‐speed autonomous obstacle avoidance with pushbroom stereo

We present the design and implementation of a small autonomous unmanned aerial vehicle capable of high‐speed flight through complex natural environments. Using only onboard GPS‐denied sensing and computation, we perform obstacle detection, planning, and feedback control in real time. We present a novel integrated approach to perception and control using pushbroom stereo, which exploits forward motion to enable efficient obstacle detection and avoidance using lightweight processors on an unmanned aerial vehicle. Our use of model‐based planning and control techniques allows us to track precise trajectories that avoid obstacles identified by the vision system. We demonstrate a complete working system detecting obstacles at 120 Hz and avoiding trees at up to 14 m/s (31 MPH). To the best of our knowledge, this is the fastest lightweight aerial vehicle to perform collision avoidance using three‐dimensional geometric information.
A Profile of Ground Reaction Forces in Professional Basketball

Basketball is a sport that involves multiple impacts with the ground through a variety of moves such as running Jumping, and cutting. Repetitive impacts have been associated with stress-related injuries in other sports such as running. The purpose of this investigation was to gain an understanding of the typical stresses the body experiences during common basketball moves. To this end, the ground reaction forces from 24 players from five professional basketball teams were studied. In addition, a game analysis was performed to determine the frequency of selected moves. These data indicated that certain common movements, such as jump landings and shuffling, resulted in absolute and relative forces much greater than many of those reported previously in studies of other sports. These movements were also identified in a companion paper as being associated with large angular excursions and velocities. Findings are discussed with respect to injury risks, and suggestions for future study are made.
Distinguishing pronounced droughts in the southwestern United States: seasonality and effects of warmer temperatures.

Abstract Higher temperatures increase the moisture-holding capacity of the atmosphere and can lead to greater atmospheric demand for evapotranspiration, especially during warmer seasons of the year. Increases in precipitation or atmospheric humidity ameliorate this enhanced demand, whereas decreases exacerbate it. In the southwestern United States (Southwest), this means the greatest changes in evapotranspirational demand resulting from higher temperatures could occur during the hot–dry foresummer and hot–wet monsoon. Here seasonal differences in surface climate observations are examined to determine how temperature and moisture conditions affected evapotranspirational demand during the pronounced Southwest droughts of the 1950s and 2000s, the latter likely influenced by warmer temperatures now attributed mostly to the buildup of greenhouse gases. In the hot–dry foresummer during the 2000s drought, much of the Southwest experienced significantly warmer temperatures that largely drove greater evapotranspir.