Miracle-dz/UniFAR-FTUs huggingface dataset:
Endogenous and exogenous hormone exposure and the risk of meningioma in men.

OBJECT Meningioma is a disease with considerable morbidity and is more commonly diagnosed in females than in males. Hormonally related risk factors have long been postulated to be associated with meningioma risk, but no examination of these factors has been undertaken in males. METHODS Subjects were male patients with intracranial meningioma (n = 456), ranging in age from 20 to 79 years, who were diagnosed among residents of the states of Connecticut, Massachusetts, and North Carolina, the San Francisco Bay Area, and 8 counties in Texas and matched controls (n = 452). Multivariate logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the association between hormonal factors and meningioma risk in men. RESULTS Use of soy and tofu products was inversely associated with meningioma risk (OR 0.50 [95% CI 0.37-0.68]). Increased body mass index (BMI) appears to be associated with an approximately 2-fold increased risk of developing meningioma in men. No other single hormone-related exposure was found to be associated with meningioma risk, although the prevalence of exposure to factors such as orchiectomy and vasectomy was very low. CONCLUSIONS Estrogen-like exogenous exposures, such as soy and tofu, may be associated with reduced risk of meningioma in men. Endogenous estrogen-associated factors such as high BMI may increase risk. Examination of other exposures related to these factors may lead to better understanding of mechanisms and potentially to intervention.
Two Membrane-Anchored Aspartic Proteases Contribute to Pollen and Ovule Development1[OPEN]

Two putative GPI-anchored aspartic proteases, A36 and A39, are involved in pollen and ovule development as well as in directional growth of the pollen tube toward ovules in Arabidopsis. Aspartic proteases are a class of proteolytic enzymes with conserved aspartate residues, which are implicated in protein processing, maturation, and degradation. Compared with yeast and animals, plants possess a larger aspartic protease family. However, little is known about most of these enzymes. Here, we characterized two Arabidopsis (Arabidopsis thaliana) putative glycosylphosphatidylinositol (GPI)-anchored aspartic protease genes, A36 and A39, which are highly expressed in pollen and pollen tubes. a36 and a36 a39 mutants display significantly reduced pollen activity. Transmission electron microscopy and terminal-deoxynucleotidyl transferase-mediated nick end labeling assays further revealed that the unviable pollen in a36 a39 may undergo unanticipated apoptosis-like programmed cell death. The degeneration of female gametes also occurred in a36 a39. Aniline Blue staining, scanning electron microscopy, and semi in vitro guidance assays indicated that the micropylar guidance of pollen tubes is significantly compromised in a36 a39. A36 and A39 that were fused with green fluorescent protein are localized to the plasma membrane and display punctate cytosolic localization and colocalize with the GPI-anchored protein COBRA-LIKE10. Furthermore, in a36 a39, the abundance of highly methylesterified homogalacturonans and xyloglucans was increased significantly in the apical pollen tube wall. These results indicate that A36 and A39, two putative GPI-anchored aspartic proteases, play important roles in plant reproduction in Arabidopsis.
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1 xxx Abstract— Streptococcus mutans (S. mutans) bacteria were killed using a low-power millimeter-size atmospheric-pressure glow-discharge plasma, or plasma needle. The plasma was applied to a culture of S. mutans that was plated onto the surface of an agar nutrient in a Petri dish. S. mutans is the most important microorganism for causing dental caries. A spatially-resolved biological diagnostic of the plasma is introduced, where the spatial pattern of bacterial colonies in the sample was imaged after plasma treatment and incubation. For low-power conditions that would be attractive for dentistry, images from this biological diagnostic reveal that S. mutans was killed within a solid circle with a 5 mm diameter, demonstrating that site-specific treatment is possible. For other conditions, which are of interest for understanding plasma transport, images show that bacteria were killed with a ring-shaped spatial pattern. This ring pattern coincides with a similar ring in the spatial distribution of energetic electrons, as revealed by Abel-inverted images of the glow. The presence of the radicals OH and O was verified using optical emission spectroscopy.
Sex Differences in the Middle Ear of the Bullfrog (Rana catesbeiana)

Impedance transformation by the middle ear of terrestrial vertebrates is considered to be a function of the ossicular lever apparatus, which increases force and decreases velocity at the stapes footplate relative to the tympanic membrane, and the ratio of tympanic membrane area to stapes footplate area (the area ratio), which increases pressure at the stapes. A recent vibrometric study has found that the velocity ratio between tympanic membrane and stapes footplate is higher in male bullfrogs (Rana catesbeiana) than in females. Although the tympanic membrane area is known to be larger in male bullfrogs, the area ratio has apparently never been compared between the sexes. The hypothesis that a lower area ratio in males helps to compensate for the higher velocity ratio was investigated by comparing tympanic membrane, stapes footplate and operculum areas in frogs of both sexes. Contrary to expectation, the difference in stapes footplate area between males and females is very small, and area ratios are considerably higher in males. Area ratios increase with increasing body size in both sexes. Operculum area does not differ between the sexes. The apparent difference in impedance transformation between male and female frogs might be necessary due to different inner ear impedances, or might reflect serious inadequacies in the conventional models of middle ear function.
Constitutive Modeling of Time-Dependent Response of Human Plantar Aponeurosis

The attention is focused on the viscoelastic behavior of human plantar aponeurosis tissue. At this purpose, stress relaxation tests were developed on samples taken from the plantar aponeurosis of frozen adult donors with age ranging from 67 to 78 years, imposing three levels of strain in the physiological range (4%, 6%, and 8%) and observing stress decay for 240 s. A viscohyperelastic fiber-reinforced constitutive model with transverse isotropy was assumed to describe the time-dependent behavior of the aponeurotic tissue. This model is consistent with the structural conformation of the tissue where collagen fibers are mainly aligned with the proximal-distal direction. Constitutive model fitting to experimental data was made by implementing a stochastic-deterministic procedure. The stress relaxation was found close to 40%, independently of the level of strain applied. The agreement between experimental data and numerical results confirms the suitability of the constitutive model to describe the viscoelastic behaviour of the plantar aponeurosis.
What You Need to Know About HOME BLOOD PRESSURE TELEMONITORING: But May Not Know to Ask

Home blood pressure (BP) telemonitoring allows patients to take their BP, store the data, and then transmit data by phone to a healthcare provider. Research to date shows that home BP telemonitoring is accurate and helps patients gain control over their blood pressure. When used regularly, home BP telemonitoring can improve control and help reduce health problems associated with hypertension.
Research on Automated Testing of the Trusted Platform Model

Trusted platform module (TPM) is a key component to trusted computing, which is proposed to improve security on general platforms. Therefore, it's very necessary to test related products. This paper proposes a conformance testing model based on state machine model with related testing strategies and develops an automated testing tool, which can deal with state space explosion and generate test suits automatically based on the database. Testing sequences customizing can also be achieved based on the testing model. We'll take security evaluation as the next step of TPM testing.
Investigation of Biases and Compensatory Strategies Using a Probabilistic Variant of the Wisconsin Card Sorting Test

The Wisconsin Card Sorting Test (WCST) evaluates a subject’s ability to shift to a new pattern of behavior in response to the presentation of unexpected negative feedback. The present study introduces a novel version of the traditional WCST by integrating a probabilistic component into its traditional rule shifting to add uncertainty to the task, as well as the option to forage for information during any particular trial. These changes transformed a task that is trivial for neurotypical individuals into a challenging environment useful for evaluating biases and compensatory strategizing. Sixty subjects performed the probabilistic WCST at four uncertainty levels to determine the effect of uncertainty on subject performance and strategy. Results revealed that increasing the level of uncertainty during a run of trials correlated with a reduction in rational strategizing in favor of both random choice and information foraging, evoking biases and suboptimal strategies such as satisfaction of search, negativity bias, and probability matching.
Radiation damping of a BPS monopole: An illustration of S duality

The radiation reaction of a BPS monopole in the presence of incident electromagnetic waves as well as massless Higgs waves is analyzed classically. The reactive force and higher-order (finite size) effect are compared to those of the W boson that is interpreted as a dual partner of the BPS monopole. It is shown that the damping of acceleration is dual to each other, while in the case of the finite size effect the duality is broken explicitly. Their implications on the duality are discussed. {copyright} {ital 1997} {ital The American Physical Society}
Intraspecific metabolic scaling exponent depends on red blood cell size in fishes

ABSTRACT The metabolic-level boundaries (MLB) hypothesis and the cell metabolism (CM) hypothesis have been proposed to explain the body mass scaling of metabolic rate. The MLB hypothesis focuses mainly on the influence of the metabolic level on the relative importance of volume and surface area constraints. The CM hypothesis focuses on the variation of cell size as the body grows. The surface area to volume ratio of individual cells may vary among species with different cell sizes, by which surface area constraints on metabolic scaling may change according to the MLB hypothesis. The present study aimed to extend the MLB and the CM hypotheses by proposing that, in addition to metabolic level, the varying cell surface area constraints among species also influence the intraspecific scaling exponents. The red blood cell area (S), and intraspecific scaling exponents for resting (bR) and maximum metabolic rates of four species of cyprinids were assessed. The scaling exponents varied among species, but mass-specific resting metabolic rates (RMR) of each species were similar. No significant correlation was found between S and mass-specific RMR among species. As predicted, a significantly negative relationship exists between S and bR among species. The results suggest that the varying bR could be attributed to cell size differences among species, as those with larger cells may face stronger surface boundary limits, as predicted by the MLB hypothesis. This mechanism represents an additional way of relating the MLB and the CM hypotheses and does not exclude another mechanism based on the recent contextual multimodal theory. Summary: An integrative mechanism of metabolic scaling is proposed: species with a larger cell size have a smaller metabolic scaling exponent as they face more pronounced surface/volume limits.
Intravenous Chloroprocaine Attenuates Hemodynamic Changes Associated with Direct Laryngoscopy and Tracheal Intubation

We compared the effects of an IV administration of chloroprocaine and lidocaine on circulatory responses associated with endotracheal intubation. Thirty patients were randomly allocated to receive normal saline (placebo), lidocaine (1.5 mg/kg), or preservative-free chloroprocaine (4.5 mg/kg) 45 s before endotracheal intubation. Blood pressures and heart rate and rhythm were recorded before laryngoscopy and at 0.5, 1, 1.5, 2, 3, and 5 min after intubation. Blood samples were analyzed for catecholamine and chloroprocaine concentrations. Chloroprocaine reduced increases in blood pressure in response to intubation when compared with patients receiving normal saline and lidocaine. Systolic blood pressures at 0.5 and 1 min after intubation were significantly lower in the chloroprocaine group when compared with both the control and lidocaine groups (P < 0.05). Diastolic and mean blood pressures were significantly lower in the chloroprocaine group at all time points until 5 min after intubation (P < 0.05). Chloroprocaine and, to a lesser degree, lidocaine, produced marked attenuation of intubation-induced increases in plasma concentration of epinephrine and norepinephrine. Plasma concentrations of norepinephrine were significantly smaller in the chloroprocaine group at 0.5, 1, and 1.5 min, and plasma concentrations of epinephrine were significantly smaller at 0.5 after intubation when compared with control and lidocaine groups (P < 0.05). Measurable concentrations of chloroprocaine were recorded in plasma samples for 2 min after its administration. No adverse chloroprocaine effects (i.e., circulatory disturbances, venous irritation) were detected. The IV administration of chloroprocaine effectively blunted cardiovascular response produced by laryngoscopy and endotracheal intubation, and this effect was more pronounced when compared with IV lidocaine. Implications The IV administration of chloroprocaine effectively blunted cardiovascular response produced by laryngoscopy and endotracheal intubation, and this effect was more pronounced when compared with IV lidocaine.
Motivational Differences in Students' Perceptions of Classroom and Standardized Achievement Tests.

How studerts perceive standardized tests and routine classroom tests on subject matter units was studied by surveying 61 fifth-grade and 65 eighth-grade students in public schools in Michigan. It was hypothesized that older students would more often distinguish between the types of test and would be more cynical and less motivated than would younger students, and that high-achieving students would express more positive attitudes in both grades compared to lower achieving students. The standardized test was the California Achievement Test. A 56-item survey assessed student attitudes. Fifth-graders did not distinguish between the types of test as much as did eighth-graders. Younger students had more positive attitudes. The highly discriminated attitudes of the eighth-graders suggest developing disillusionment with standardized tests, a growing sense of their unimportance, and a suspicion of their validity. By grade 8, students did not incorporate standardized test results in their perceptions of their own ability. A 9-item list of references is included. Three tables present study data and survey questions. (SLD) ************tt********************************************************* Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** U.S. DEPARTMENT OF EDUCATION Office ot Educational Reward) and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) Vics document has been reproduced as received from the person or organiration originating it Minor changes have been made to improve reproductior twality Points ol yieis or opinions stated in this docu ment do mil necessarily represent official OERI pned on or policy "PERMISSION TO REPRODUCE THIS MATERIAL HAS BEEN GRANTED BY 1'4 Z Aril? TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC). " Motivational Differences in Students' Perceptions of Classroom and Standardized
Quantum Network Communication—The Butterfly and Beyond

We study the problem of k-pair communication (or multiple unicast problem) of quantum information in networks of quantum channels. We consider the asymptotic rates of high fidelity quantum communication between specific sender-receiver pairs. Four scenarios of classical communication assistance (none, forward, backward, and two-way) are considered. (I) We obtain outer and inner bounds of the achievable rate regions in the most general directed networks. (II) For two particular networks (including the butterfly network), routing is proved optimal, and the free assisting classical communication can at best be used to modify the directions of quantum channels in the network. Consequently, the achievable rate regions are given by counting edge avoiding paths, and precise achievable rate regions in all four assisting scenarios can be obtained. (III) Optimality of routing can also be proved in classes of networks. The first class consists of directed unassisted networks in which (1) the receivers are information sinks, (2) the maximum distance from senders to receivers is small, and (3) a certain type of 4-cycles are absent, but without further constraints (such as on the number of communicating and intermediate parties). The second class consists of arbitrary backward-assisted networks with two sender-receiver pairs. (IV) Beyond the k-pair communication problem, observations are made on quantum multicasting and a static version of network communication related to the entanglement of assistance.
Comparison of QuantiFERON-TB Gold In-Tube Test and Tuberculin Skin Test for Identification of Latent Mycobacterium tuberculosis Infection in Healthcare Staff and Association Between Positive Test Results and Known Risk Factors for Infection

Objective. We compared a whole-blood interferon-γ release assay (QuantiFERON-TB Gold In-Tube test, hereafter “QFT-in tube test”) with a tuberculin skin test (TST) to determine which test more accurately identified latent Mycobacterium tuberculosis infection in healthcare staff. Methods. A total of 481 hospital staff members were recruited from 5 hospitals in Melbourne, Australia. They provided information about demographic variables and tuberculosis (TB) risk factors (ie, birth or travel in a country with a high prevalence of TB, working in an occupation likely to involve contact with M. tuberculosis or individuals with TB, or being a household contact of an individual with a proven case of pulmonary TB). The QFT-in tube test and the TST were administered in accordance with standardized protocols. Concordance between the test results and positive risk factors was analyzed using the к statistic, the McNemar test, and logistic regression. Results. A total of 358 participants had both a TST result and a QFT-in tube test result available for comparison. There were fewer positive QFT-in tube test results than positive TST results (6.7% vs. 33.0%; P < .001). Agreement between the tests was poor (71%; к = 0.16). A positive QFT-in tube test result was associated with birth in a country with a high prevalence of TB, the number of years an individual had lived in a country with a high prevalence of TB (ie, the effect of each additional year, treated as a continuous variable), and high-risk occupational contact. A positive TST result was associated with older age, receipt of bacille Calmette-Guérin (BCG) vaccination, and working in an occupation that involved patient contact. Receipt of BCG vaccination was most strongly associated with discordant results in instances in which the TST result was positive and the QFT-in tube test result was negative. Conclusion. In a population of healthcare staff with a low prevalence of TB and a significant rate of BCG vaccination, a positive QFT-in tube test result was associated with the presence of known risk factors for TB exposure, whereas a positive TST result was more strongly associated with a prior history of BCG vaccination.
Enhancement of GluN2B Subunit-Containing NMDA Receptor Underlies Serotonergic Regulation of Long-Term Potentiation after Critical Period in the Rat Visual Cortex

Serotonin [5-hydroxytryptamine (5-HT)] regulates synaptic plasticity in the visual cortex. Although the effects of 5-HT on plasticity showed huge diversity depending on the ages of animals and species, it has been unclear how 5-HT can show such diverse effects. In the rat visual cortex, 5-HT suppressed long-term potentiation (LTP) at 5 weeks but enhanced LTP at 8 weeks. We speculated that this difference may originate from differential regulation of neurotransmission by 5-HT between the age groups. Thus, we investigated the effects of 5-HT on apha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-, γ-aminobutyric acid receptor type A (GABAAR)-, and N-methyl-D-aspartic acid receptor (NMDAR)-mediated neurotransmissions and their involvement in the differential regulation of plasticity between 5 and 8 weeks. AMPAR-mediated currents were not affected by 5-HT at both 5 and 8 weeks. GABAAR-mediated currents were enhanced by 5-HT at both age groups. However, 5-HT enhanced NMDAR-mediated currents only at 8 weeks. The enhancement of NMDAR-mediated currents appeared to be mediated by the enhanced function of GluN2B subunit-containing NMDAR. The enhanced GABAAR- and NMDAR-mediated neurotransmissions were responsible for the suppression of LTP at 5 weeks and the facilitation of LTP at 8 weeks, respectively. These results indicate that the effects of 5-HT on neurotransmission change with development, and the changes may underlie the differential regulation of synaptic plasticity between different age groups. Thus, the developmental changes in 5-HT function should be carefully considered while investigating the 5-HT-mediated metaplastic control of the cortical network.
Zwischen Integration und Ausschluss. Die Klassenpositionen von Migranten im Zeit- und Generationenvergleich

Die „klassischen“ Arbeitsmigranten und deren Nachkommen verfugen in Deutschland bekanntermasen uber schlechtere Erwerbschancen als Einheimische. Weniger untersucht sind dagegen Veranderungen im Zeitvergleich und strukturelle Faktoren des Arbeitsmarktes, wie sie durch unterschiedliche Klassenpositionen abgebildet werden. Die Analysen der Scientific Use Files der Mikrozensen 1976 und 2008 zeigen, dass Migranten aus den ehemaligen Anwerbelandern nach wie vor uberproportional haufig untere Erwerbspositionen einnehmen; jedoch schneidet die zweite Generation der Migranten insgesamt erfolgreicher als die erste Generation ab. Im Bereich der Klassenpositionen erweist sich vor allem der Zugang zur selbststandigen Tatigkeit und zum Facharbeitersegment als weitgehend offen, wahrend die Chancen fur Migranten in den qualifizierten Angestellten- und Dienstklassenpositionen weiterhin schlechter ausfallen. Fur das Jahr 2008 ist keine generelle Benachteiligung der Migranten turkischer Herkunft festzustellen.