Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth.

IMPORTANCE Cancer is caused by a diverse array of somatic and germline genomic aberrations. Advances in genomic sequencing technologies have improved the ability to detect these molecular aberrations with greater sensitivity. However, integrating them into clinical management in an individualized manner has proven challenging. OBJECTIVE To evaluate the use of integrative clinical sequencing and genetic counseling in the assessment and treatment of children and young adults with cancer. DESIGN, SETTING, AND PARTICIPANTS Single-site, observational, consecutive case series (May 2012-October 2014) involving 102 children and young adults (mean age, 10.6 years; median age, 11.5 years, range, 0-22 years) with relapsed, refractory, or rare cancer. EXPOSURES Participants underwent integrative clinical exome (tumor and germline DNA) and transcriptome (tumor RNA) sequencing and genetic counseling. Results were discussed by a precision medicine tumor board, which made recommendations to families and their physicians. MAIN OUTCOMES AND MEASURES Proportion of patients with potentially actionable findings, results of clinical actions based on integrative clinical sequencing, and estimated proportion of patients or their families at risk of future cancer. RESULTS Of the 104 screened patients, 102 enrolled with 91 (89%) having adequate tumor tissue to complete sequencing. Only the 91 patients were included in all calculations, including 28 (31%) with hematological malignancies and 63 (69%) with solid tumors. Forty-two patients (46%) had actionable findings that changed their cancer management: 15 of 28 (54%) with hematological malignancies and 27 of 63 (43%) with solid tumors. Individualized actions were taken in 23 of the 91 (25%) based on actionable integrative clinical sequencing findings, including change in treatment for 14 patients (15%) and genetic counseling for future risk for 9 patients (10%). Nine of 91 (10%) of the personalized clinical interventions resulted in ongoing partial clinical remission of 8 to 16 months or helped sustain complete clinical remission of 6 to 21 months. All 9 patients and families with actionable incidental genetic findings agreed to genetic counseling and screening. CONCLUSIONS AND RELEVANCE In this single-center case series involving young patients with relapsed or refractory cancer, incorporation of integrative clinical sequencing data into clinical management was feasible, revealed potentially actionable findings in 46% of patients, and was associated with change in treatment and family genetic counseling for a small proportion of patients. The lack of a control group limited assessing whether better clinical outcomes resulted from this approach than outcomes that would have occurred with standard care.
Global Air Pollution Crossroads over the Mediterranean

The Mediterranean Intensive Oxidant Study, performed in the summer of 2001, uncovered air pollution layers from the surface to an altitude of 15 kilometers. In the boundary layer, air pollution standards are exceeded throughout the region, caused by West and East European pollution from the north. Aerosol particles also reduce solar radiation penetration to the surface, which can suppress precipitation. In the middle troposphere, Asian and to a lesser extent North American pollution is transported from the west. Additional Asian pollution from the east, transported from the monsoon in the upper troposphere, crosses the Mediterranean tropopause, which pollutes the lower stratosphere at middle latitudes.
Regulation of G Protein-Coupled Receptor Signaling by A-Kinase Anchoring Proteins

Specificity of transduction events is controlled at the molecular level by scaffold, anchoring, and adaptor proteins, which position signaling enzymes at proper subcellular localization. This allows their efficient catalytic activation and accurate substrate selection. A-kinase anchoring proteins (AKAPs) are group of functionally related proteins that compartmentalize the cAMP-dependent protein kinase (PKA) and other signaling enyzmes at precise subcellular sites in close proximity to their physiological substrate(s) and favor specific phosphorylation events. Recent evidence suggests that AKAP transduction complexes play a key role in regulating G protein-coupled receptor (GPCR) signaling. Regulation can occur at multiple levels because AKAPs have been shown both to directly modulate GPCR function and to act as downstream effectors of GPCR signaling. In this minireview, we focus on the molecular mechanisms through which AKAP-signaling complexes modulate GPCR transduction cascades.
Management of cervical incompetence in Aba, south-eastern Nigeria.

BACKGROUND There have been relatively few reports on the outcome of cervical cerclage performed in non-tertiary centres. The aim of this study was to determine the pregnancy complications and outcome in patients following cervical cerclage. METHODS Seventy-one patients who had 103 pregnancies and underwent cervical cerclage at Women's Hospital, Aba over a ten-year period were reviewed. The diagnosis of cervical incompetence was made from the history in 90.6% of cases and also in some cases by hysterosalpingography and ultrasonography. RESULTS The Shirodkar (65%) and McDonald (35%) techniques were employed and 10.7% of cases were done as emergency procedures. The more common post-insertion complications were urinary tract infection (50.4%), preterm rupture of membranes (20.4%) and vulvovaginitis (14.6%). Common labour associated complications were antepartum haemorrhage, perineal/cervical tears and malpresentations. The preterm birth rate was 32%. Term births accounted for 68% of the deliveries. The overall fetal salvage rate was 92.2%. Antepartum haemorrhge was a significant indication for caesarean section delivery. The perinatal mortality was 63.2 per 1000 and there was no maternal death. CONCLUSION The high fetal salvage rate of 92.2% justifies the procedure of cervical cerclage.
The NEO Personality Inventory–Revised

This study presents new analyses of NEO Personality Inventory–Revised (NEO-PI-R) responses collected from a large British sample in a high-stakes setting. The authors show the appropriateness of the five-factor model underpinning these responses in a variety of new ways. Using the recently developed exploratory structural equation modeling (ESEM) technique, the authors show that model fits improve markedly over conventional confirmatory factor analyses (CFA) of the same data set, but that (a) factor interpretations do not change under ESEM analyses, (b) ESEM factor scores, just like CFA factors scores, correlate at near unity with sums of observed scores, (c) NEO-PI-R facets under ESEM analyses are invariant across gender, and (d) ESEM highlights the inappropriateness of alpha and beta as a higher order representation of NEO-PI-R facets, whereas a CFA approach might lead researchers to believe in the appropriateness of these higher order factors. These results, coupled with the existing validity evidence for the NEO-PI-R, suggest that the five-factor structure is the most parsimonious structure for summarizing NEO-PI-R responses from high-stakes settings in the United Kingdom.
Why does self-reported emotional intelligence predict job performance? A meta-analytic investigation of mixed EI.

Recent empirical reviews have claimed a surprisingly strong relationship between job performance and self-reported emotional intelligence (also commonly called trait EI or mixed EI), suggesting self-reported/mixed EI is one of the best known predictors of job performance (e.g., ρ = .47; Joseph & Newman, 2010b). Results further suggest mixed EI can robustly predict job performance beyond cognitive ability and Big Five personality traits (Joseph & Newman, 2010b; O'Boyle, Humphrey, Pollack, Hawver, & Story, 2011). These criterion-related validity results are problematic, given the paucity of evidence and the questionable construct validity of mixed EI measures themselves. In the current research, we update and reevaluate existing evidence for mixed EI, in light of prior work regarding the content of mixed EI measures. Results of the current meta-analysis demonstrate that (a) the content of mixed EI measures strongly overlaps with a set of well-known psychological constructs (i.e., ability EI, self-efficacy, and self-rated performance, in addition to Conscientiousness, Emotional Stability, Extraversion, and general mental ability; multiple R = .79), (b) an updated estimate of the meta-analytic correlation between mixed EI and supervisor-rated job performance is ρ = . 29, and (c) the mixed EI-job performance relationship becomes nil (β = -.02) after controlling for the set of covariates listed above. Findings help to establish the construct validity of mixed EI measures and further support an intuitive theoretical explanation for the uncommonly high association between mixed EI and job performance--mixed EI instruments assess a combination of ability EI and self-perceptions, in addition to personality and cognitive ability.
Odontogenic cysts: analysis of 2,944 cases in Chile.

INTRODUCTION Odontogenic cysts constitute a group of frequent intraosseous lesions characteristic in the maxillary bones and one of the main causes of the destruction of these bones. In Chile there are no retrospective studies of these lesions as a whole. OBJECTIVE The purpose of this study is to determine the frequency of these lesions in so far as they were diagnosed and registered in the Referral Institute for Oral Pathology (IREPO) of the University of Chile in two age groups as well as to analyze and to compare the data obtained with the data published in previous studies. MATERIAL AND METHOD We studied the records from IREPO of the University of Chile for the period between 1976 and September, 2004; and we determined the frequency according to age, gender and site of each of these lesions. We compare two age groups: younger than or equal to 15 years old and older than 15 years old. Those cases in which the information did not suffice for the purposes of analysis were not considered. All the histological slides were reclassiffed according to the diagnostic criteria included in the Histological Typification of the World Health Organization. RESULTS We found 2.944 odontogenic cysts (OC), of which 1.935 (65.7%) were inflammatory cysts and 1.009 were developmental cysts. Out of this total, there were 1.554 cysts (52.8%) in men and 1.390 (47.2%) in women. The most frequent cysts were 1.494 radicular cysts (50.7%), 546 dentigerous cysts (18.5%), 421 keratocysts (14.3%) and 328 residual cysts (11.1%). These four varieties represent 94.7% of the OC , that is, 2789 cases. In the population younger than or equal to 15 years of age the developmental cysts (354 cases) are more frequent than the inflammatory cysts (155 cases), the most frequent being dentigerous cysts (240 cases).
Extramedullary versus intramedullary tibial alignment technique in total knee arthroplasty: A meta-analysis of randomized controlled trials

The aim of this study was to establish whether the use of an extramedullary or intramedullary tibial cutting guide leads to superior mechanical leg axis and implant positioning. A meta-analysis of six randomized controlled trials including 350 knees was performed. For the mechanical axis, frontal tibial component angle and tibial slope, there were no significant differences in the mean values or the number of outliers (±3°) between the extramedullary and intramedullary groups. A reduced tourniquet time was associated with the intramedullary guide. No significant difference in the complication rate was noted between the two groups. Neither extramedullary nor intramedullary tibial alignment was more accurate in facilitating the tibial cut. Use of an intramedullary guide results in a shorter tourniquet time and exhibits a similar complication rate as the extramedullary guide.
A systematic review of biologic and technical complications with fixed implant rehabilitations for edentulous patients.

PURPOSE The purpose of this systematic review was to assess the incidence and types of biologic and technical complications associated with implant-supported fixed complete dental prostheses (IFCDPs) for edentulous patients. MATERIALS AND METHODS An electronic MEDLINE/PubMED search was conducted to identify randomized controlled clinical trials and prospective cohort studies with IFCDPs for edentulous patients. Reports with at least 5 years of follow-up after prosthesis insertion were selected. Pooled data were analyzed statistically, and the cumulative complication rates were calculated by meta-analysis and regression. RESULTS Of a total of 281 one-piece IFCDPs (mean exposure time of 9.5 years) and 653 complication events, the complication rate was estimated at 24.6% per 100 restoration-years. The cumulative rates of "prosthesis free of complications" after 5 and 10 years were 29.3% and 8.6%, respectively. The most common implantrelated biologic complication was peri-implant bone loss (> 2 mm), at rates of 20.1% after 5 years and 40.3% after 10 years. The most frequent implant-related technical complication was screw fracture, yielding a 5-year complication rate of 10.4% and a 10-year rate of 20.8%. The most frequent prosthesis-related biologic complication was hypertrophy or hyperplasia of tissue around the IFCDPs (13.0% and 26.0% after 5 and 10 years, respectively). The most common prosthesis-related technical complication reported with IFCDPs was chipping or fracture of the veneering material (33.3% at 5 years and 66.6% at 10 years). CONCLUSION Biologic and technical complications after the placement of IFCDPs occur continuously over time as a result of fatigue and stress. These events may not lead to implant/prosthetic failures, but they are significant in relation to the amount of repair and maintenance needed, time, and cost to both the clinician and patient.
Analysis of multi-threading time metric on single and multi-core CPUs with Matrix Multiplication

There has always been a debate over the advantages of multi-core architecture over single core. the full advantage of multi-core can be attained when the load is spread evenly all among the available cores [Amdahl's law]. In this context, improving the performance of the system with time constraints can be achieved by running parallel threads on cores.
Semantic Parsing for High-Precision Semantic Role Labelling

In this paper, we report experiments that explore learning of syntactic and semantic representations. First, we extend a state-of-the-art statistical parser to produce a richly annotated tree that identifies and labels nodes with semantic role labels as well as syntactic labels. Secondly, we explore rule-based and learning techniques to extract predicate-argument structures from this enriched output. The learning method is competitive with previous single-system proposals for semantic role labelling, yields the best reported precision, and produces a rich output. In combination with other high recall systems it yields an F-measure of 81%.
Sustainability reporting in family firms: A panel data analysis

We analyze the largely unexplored differences in sustainability reporting within family businesses using a sample of 230 non-financial Italian listed firms for the period 2004–2013. Drawing on legitimacy theory and stakeholder theory, integrated with the socio-emotional wealth (SEW) approach, we study how family control, influence and identification shape a firm’s attitude towards disclosing its social and environmental behavior. Our results suggest that family firms are more sensitive to media exposure than their non-family counterparts and that family control enhances sustainability disclosure when it is associated to a family’s direct influence on the business, by the founder’s presence on the board or by having a family CEO. In cases of indirect influence, without family involvement on the board, the level of family ownership is negatively related to sustainability reporting. On the other hand, a formal identification of the family with the firm by business name does not significantly affect social disclosure.
Critical phenomena in gravitational collapses of neutron star systems

We study critical phenomena in gravitational collapses of stellar objects based on numerical solutions of the Einstein equations. We discovered that stellar objects with large kinetic energy described by an equation of state (EOS) commonly used in describing neutron star matter may undergo critical collapses. To the best of our knowledge, this is the first study showing that critical collapses can occur without postulating an exotic EOS. We further showed that the critical collapses can occur due to an adiabatic change of the EOS, without fine tuning of the initial conditions. This opens the possibility that a neutron-star-like compact object with substantial kinetic energy, e.g. one newly formed in a supernova or in a binary coalescence, may undergo a critical collapse in processes which change the EOS, such as cooling. We investigated the properties of the critical solutions of this system. We found, surprisingly, that there are branches of critical solutions, and a complicated phase diagram not been seen in other critical collapse studies. The numerical simulations were carried out based on the full set of the Einstein equations coupled to the general relativistic hydrodynamic equations. The code we
Prevalence of gestational trophoblastic disease. A single institution experience.

OBJECTIVE To study the incidence and time trends of gestational trophoblastic disease in the Kingdom of Saudi Arabia (KSA). METHODS A retrospective study of medical records of 64,762 pregnancies registered and treated at Security Forces Hospital, Riyadh, KSA, from January 1988 through to December 1998. RESULTS Fifty-nine cases of hydatidiform mole (36 complete hydatidiform mole (CHM) and 23 partial hydatidiform mole (PHM) and 2 cases of choriocarcinoma were observed, out of 64,762 pregnancies registered at Security Forces Hospital, Riyadh, KSA, during an 11 year period. The temporal trends exhibited significant reduction in the incidence of GTD during the study period. CONCLUSION The incidence of GTD has declined with the rapid socio-medical development of the KSA, and is now comparable to that of Europe. The optimal management of this disease depends on prompt diagnosis, correct stratification of the risk category and appropriate treatment using various modalities such as chemotherapy and surgery.
Efficient rare event simulation for heavy-tailed compound sums

We develop an efficient importance sampling algorithm for estimating the tail distribution of heavy-tailed compound sums, that is, random variables of the form <i>S</i><sub><i>M</i></sub>=<i>Z</i><sub>1</sub>+&cdots;+<i>Z</i><sub><i>M</i></sub> where the <i>Z</i><sub><i>i</i></sub>'s are independently and identically distributed (i.i.d.) random variables in R and <i>M</i> is a nonnegative, integer-valued random variable independent of the <i>Z</i><sub><i>i</i></sub>'s. We construct the first estimator that can be rigorously shown to be strongly efficient only under the assumption that the <i>Z</i><sub><i>i</i></sub>'s are subexponential and <i>M</i> is light-tailed. Our estimator is based on state-dependent importance sampling and we use Lyapunov-type inequalities to control its second moment. The performance of our estimator is empirically illustrated in various instances involving popular heavy-tailed models.
Annals of the New York Academy of Sciences Contending with Uncertainty in Conservation Management Decisions

Efficient conservation management is particularly important because current spending is estimated to be insufficient to conserve the world's biodiversity. However, efficient management is confounded by uncertainty that pervades conservation management decisions. Uncertainties exist in objectives, dynamics of systems, the set of management options available, the influence of these management options, and the constraints on these options. Probabilistic and nonprobabilistic quantitative methods can help contend with these uncertainties. The vast majority of these account for known epistemic uncertainties, with methods optimizing the expected performance or finding solutions that achieve minimum performance requirements. Ignorance and indeterminacy continue to confound environmental management problems. While quantitative methods to account for uncertainty must aid decisions if the underlying models are sufficient approximations of reality, whether such models are sufficiently accurate has not yet been examined.
A Bayesian approach to characterizing uncertainty in inverse problems using coarse and fine-scale information

The Bayesian approach allows one to easily quantify uncertainty, at least in theory. In practice, however, the Markov chain Monte Carlo (MCMC) method can be computationally expensive, particularly in complicated inverse problems. We present a methodology for improving the speed and efficiency of an MCMC analysis by combining runs on different scales. By using a coarser scale, the chain can run faster (particularly when there is an external forward simulator involved in the likelihood evaluation) and better explore the posterior, being less likely to become stuck in local maxima. We discuss methods for linking the coarse chain back to the original fine-scale chain of interest. The resulting coupled chain can thus be run more efficiently without sacrificing the accuracy achieved at the finer scale.
Structure-Based Stabilization of HIV-1 gp120 Enhances Humoral Immune Responses to the Induced Co-Receptor Binding Site

The human immunodeficiency virus type 1 (HIV-1) exterior envelope glycoprotein, gp120, possesses conserved binding sites for interaction with the primary virus receptor, CD4, and also for the co-receptor, generally CCR5. Although gp120 is a major target for virus-specific neutralizing antibodies, the gp120 variable elements and its malleable nature contribute to evasion of effective host-neutralizing antibodies. To understand the conformational character and immunogenicity of the gp120 receptor binding sites as potential vaccine targets, we introduced structure-based modifications to stabilize gp120 core proteins (deleted of the gp120 major variable regions) into the conformation recognized by both receptors. Thermodynamic analysis of the re-engineered core with selected ligands revealed significant stabilization of the receptor-binding regions. Stabilization of the co-receptor-binding region was associated with a marked increase in on-rate of ligand binding to this site as determined by surface plasmon resonance. Rabbit immunization studies showed that the conformational stabilization of core proteins, along with increased ligand affinity, was associated with strikingly enhanced humoral immune responses against the co-receptor-binding site. These results demonstrate that structure-based approaches can be exploited to stabilize a conformational site in a large functional protein to enhance immunogenic responses specific for that region.