Miracle-dz/UniFAR-FTUs huggingface dataset:
Revisiting the Medical Management of Parkinson's Disease: Levodopa versus Dopamine Agonist

The optimal treatment strategy for Parkinson's disease has been debated for decades. The introduction of levodopa (LD) treatment is frequently delayed because of theoretical concerns about its toxicity or the risk of drug-induced motor complications. These concerns have resulted in “LD phobia” with clinicians selecting dopamine agonist (DA) over LD as initial therapy. More recently, a shift in the treatment approach towards initial LD use appears to be occurring. It is therefore necessary to review current evidence for the use of LD and DA. This review discusses the medical management of Parkinson's disease with regards to the use of LD versus DA. Pendulum swings in treatment strategies between LD-first and DA-first therapies should be avoided. A balanced perspective is needed as there is a place for both drugs in the management of PD.
Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity

Previous research has shown that the human brain can be represented as a complex functional network that is characterized by specific topological properties, such as clustering coefficient, characteristic path length, and global/local efficiency. Patients with psychotic disorder may have alterations in these properties with respect to controls, indicating altered efficiency of network organization. This study examined graph theoretical changes in relation to differential genetic risk for the disorder and aimed to identify clinical correlates.
Utterance Processing and Semantic Underspecification

We propose a theory of utterance processing meant to clarify the respective roles of incrementality and underspecification in semantic interpretation. After reviewing the available psychological evidence, we introduce (i) a theory of the semantic interpretations constructed by the language processor while processing utterances in an incremental fashion, including the cases in which these interpretations are semantically underspecified; and (ii) a formal model of the disambiguation process. We use our theory to account for the psychological findings concerning two areas of semantic interpretation: lexical disambiguation and pronoun resolution, emphasizing similarities and differences between the two processes. We also make a few preliminary hypotheses about scope disambiguation. The novel aspects of our proposal with respect to previous work on semantic underspecification include our emphasis on psychological evidence, our use of a standard logical formalism to characterize semantically underspecified interpretations rather than logics specially developed for this purpose, and the role in the theory of logics for defeasible reasoning, which are used to give a formal characterization of certain types of interpretations observed in psychological experiments.
Lysyl oxidase-like protein 1 (LOXL1) gene polymorphisms and exfoliation glaucoma in a Central European population

Purpose Exfoliation syndrome (XFS) is characterized by an accumulation of abnormal extracellular material in the anterior part of the eye that frequently leads to increased intraocular pressure and glaucomatous optic neuropathy. Recently, two non-synonymous polymorphisms (rs1048661 G>T and rs3825942 G>A) of lysyl oxidase-like protein 1 (LOXL1), a monoamine oxidase that catalyzes the polymerization of tropoelastin to elastin, were found to be associated with increased risk for XFS and exfoliation glaucoma (XFG). The aim of the present study was to investigate the role of these LOXL1 variants in a Central European cohort of Caucasian patients with XFG. Methods The present case-control study comprised of 167 unrelated patients with XFG and 170 control subjects. Genotyping of the LOXL1 rs1048661 and rs3825942 polymorphisms was done using polymerase chain reaction. Results The frequency of allele G of rs1048661 as well as rs3825942 was significantly higher in patients than in controls (rs1048661: 0.841 in patients versus 0.669; p<0.001; rs3825942: 0.994 in patients versus 0.817; p<0.001). Odds ratios of 52.1 (95% confidence interval [CI]: 13.85–195.6) and 14.67 (95% CI: 3.81–56.2), respectively, were calculated for the two high-risk haplotypes GG and TG compared to the haplotype GA. Conclusions Our data confirm the previously reported association between LOXL1 polymorphisms and XFG and extend our knowledge to a Central European population.
Filamin concentration in cleavage furrow and midbody region: frequency of occurrence compared with that of alpha-actinin and myosin

Affinity-purified rabbit antibody to purified chicken gizzard filamin was used in indirect immunofluorescence to localize filamin in dividing chick embryo cells. The antibody was shown to bind only chick embryo cell filamin when whole cell extracts were analyzed by the sensitive sodium dodecyl sulfate-polyacrylamide gel electrophoresis overlay technique described by Adair et al. (1978, J. Cell Biol. 790:281-285). The results show that filamin is located in stress fibers and membrane ruffles during interphase. As cells prophase, the condensing chromosomes are surrounded by diffuse antifilamin staining. No stress fibers are apparent. During metaphase and anaphase, the staining is bright but diffuse. There is often peripheral membrane staining. Filamin is not concentrated in the spindle region but neither is it excluded from the spindle. During cytokinesis, filamin is found highly concentrated in the cleavage furrow in 16 out of 100 cells examined. This frequency of concentration in the furrow is comparable to that observed for alpha-actinin (14%). Myosin concentration in the furrow is more frequent; it is observed in 37% of the cells examined. Neither myosin, alpha-actinin, nor filamin is observed concentrated in the furrow 100% of the time. We conclude that the results are consistent with, but not sufficient to prove, the hypothesis that alpha-actinin and filamin are essential components of the mechanism of cytokinesis.
Macro Cell Muting Coordination for Non-Uniform Topologies in LTE-A HetNets

Enhanced Inter Cell Interference Coordination (eICIC) for co-channel deployments of pico cells throughout a macro cell layout is studied. In particular, we analyze a scenario where only some macro cells have picos deployed, while other macro cells have no small cells. The challenge for such highly irregular scenarios is how to operate eICIC, and especially how to coordinate macro-cell muting. Our analysis shows that for eICIC to provide gain in such scenarios, it is recommended to use fully time aligned traditional Almost Blank Subframes (ABS) in the macro-cells with picos, while first tier surrounding macro cells shall use low-power ABS. For such cases, user throughput gains of 30%-40% are still achievable. Moreover, it is demonstrated that if macro muting patterns are not fully time aligned, it causes additional interference fluctuations in the network, resulting in less efficient link adaptation and radio-aware packet scheduling.
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation

Skeletal muscle regeneration is a highly complex and regulated process that involves muscle precursor proliferation and differentiation and probably requires the participation of heparin binding growth factors such as FGFs, HGF and TGFβ. Heparan sulfate proteoglycans, key components of cell-surfaces and ECM, modulate growth factor activities and influence cell growth and differentiation. Their expression in forming muscle masses during development and in cell culture, suggest their participation in the regulation of myogenesis. In the present study, heparan sulfate proteoglycan expression in skeletal muscle regeneration induced by barium chloride injection was evaluated. Expression of muscle differentiation markers and neuromuscular junction (NMJ) components was characterized. Immunoblots with anti-Δ-heparan sulfate antibody showed that four major species - perlecan, glypican, syndecan-3 and syndecan-4 - were transiently up-regulated. The first three were detected at the surface or basement membranes of newly formed myotubes by specific indirect immunofluorescence. Syndecan-3, a satellite cell marker, showed the earliest and most significant increase. Experiments involving myoblast grafting into regenerating muscle showed that C2C12 cell clones, with inhibited syndecan-3 expression resulting from antisense transfection, presented a normal proliferation rate but an impaired capacity to fuse and form skeletal muscle fibers. These data constitute the first in vivo evidence suggesting the requirement of a specific heparan sulfate proteoglycan for successful skeletal muscle regeneration.
Nucleic acid melting by Escherichia coli CspE

Escherichia coli contains nine members of the CspA family. CspA and some of its homologues play critical role in cold acclimation of cells by acting as RNA chaperones, destabilizing nucleicacid secondary structures. Disruption of nucleic acid melting activity of CspE led to loss of its transcription antitermination activity and consequently its cold acclimation activity. To date, the melting activity of Csp proteins was studied using partially double-stranded model nucleic acids substrates forming stem–loop structures. Here, we studied the mechanism of nucleic acid melting by CspE. We show that CspE melts the stem region in two directions, that CspE-induced melting does not require the continuity of the substrate's loop region, and CspE can efficiently melt model substrates with single-stranded overhangs as short as 4 nt. We further show that preferential binding of CspE at the stem–loop junction site initiates melting; binding of additional CspE molecules that fully cover the single-stranded region of a melting substrate leads to complete melting of the stem.
The Origin of Blue Cores in Hubble Deep Field E/S0 Galaxies

In this Letter we address the problem of the origin of blue cores and inverse color gradients in early-type galaxies reported in the Hubble Deep Field-North and Hubble Deep Field-South by Menanteau, Abraham, & Ellis. We use a multizone single-collapse model. This model accounts for the observed blue cores by adopting a broad spread in formation redshifts for elliptical galaxies, allowing some of these galaxies to begin forming no more than ~1 Gyr before the redshift of observation. The single-zone collapse model then produces cores that are bluer than the outer regions because of the increase of the local potential well toward the center, which makes star formation more extended in the central region of the galaxy. We compare the predicted V606-I814(r) color gradients with those observed using the redshift of formation (zF) of the elliptical as the only free parameter. We find that the model can account with relatively good agreement for the blue cores and inverse color gradients found in many spheroidals and at the same time for the red and smooth color profiles reported. Based on the model, our analysis suggests two populations of field elliptical galaxies, one formed recently, within ≲1 Gyr, and another much older, formed ≳4 Gyr since the redshift of observation.
Penumbral models in the light of Hinode spectropolarimetric observations

Aims. The realism of current models of the penumbra is assessed by comparing their predictions with the plasma properties of penumbral filaments as retrieved from spectropolarimetric observations. Methods. The spectropolarimeter onboard Hinode allows us, for the first time, to distinguish the fine structure of the penumbra. Therefore, we can use one-component inversions to obtain the stratifications of plasma parameters in each pixel. The correlations between the plasma parameters and the continuum intensity are studied. Results. We find that, in the outer penumbra, the stronger flows and higher values of magnetic field inclination tend to be located in dark filaments. This finding does not seem to be compatible with the scenario of a field-free gappy penumbra.
Provincial Bank Privatization in Argentina: The Why, How, and so What?

Argentina's provinces offer a unique opportunity to study bank privatization because so many transactions took place there in so short a period in the 1990s (1994-98). As the decade started, every province owned at least one bank, performance in publicly owned provincial banks was substantially worse than in private banks, and the losses incurred imposed substantial fiscal costs on the provinces. Politicians whose provinces were in dire fiscal straits, their banks losing money at a faster rate, were most willing to seize opportunities to privatize, even though overstaffed provincial banks were harder to privatize. Deposit loss and liquidity problems associated with the Tequila crisis made privatization more likely. The right political situation is necessary but not sufficient to ensure good privatizations. First, one must find a buyer, and Argentina's provincial banks were the least attractive in the banking sector. So the provinces settled for purchasers that were not first-tier banks. Many of them were small wholesale banks that had to make the difficult transition to retail banking. Three important concessions were made to purchasers: contracts to provide post-privatization services to the provinces, portfolio guarantees, and the assumption of only"good"assets. In return, provincial politicians were granted restrictions on branch closings and layoffs of bank employees. Both types of accommodation were costly to the purchasers and the provinces. These transactions probably could not have been completed without long-term loans from the Fondo Fiduciario. Were the Fondo Fiduciario loan funds put to good use? Did privatization leave provincial banking on a sounder footing? Initial indications are that the situation has improved in most provinces. And the provinces experiencing post-privatization difficulties tend not to have participated fully in the Fondo Fiduciario privatization program. But the privatized banks rely on their service contracts with provinces to generate a big share of their income and are having trouble making the transition to commercial banking. It is uncertain whether the newly created banks are sustainable . But at least a fiscal burden has been lifted from the provinces.
Interleukin-23R rs7517847 T/G Polymorphism Contributes to the Risk of Crohn's Disease in Caucasians: A Meta-Analysis

The association between Interleukin-23R gene polymorphism and Crohn's disease (CD) in Caucasians is still controversial. Thus, a meta-analysis was performed to evaluate the correlation between this gene variant and CD risk. We retrieved the available data from EMBASE and PUBMED until May 1, 2014, and evaluated the effect of rs7517847 in Caucasians. The significant associations were confirmed between rs7517847 and CD risk in dominant models (TT/TG versus GG: OR = 1.652, 95% CI 1.277, 2.137), allelic model (T allele versus G allele: OR = 1.327, 95% CI 1.198, 1.469), homozygote comparison (TT versus GG: OR = 1.890, 95% CI 1.465, 2.437), heterozygote comparison (TG versus GG: OR = 1.509, 95% CI 1.161, 1.960), and recessive model (TT versus TG/GG: OR = 1.409, 95% CI 1.279, 1.552). In conclusion, this meta-analysis demonstrates that rs7517847 is associated with the risk of CD in Caucasians. These findings show that IL-23R genes confer susceptibility to CD in the Caucasians.
Effects of Sexting on Perceptions of Sexual Intent, Sexual Consent, and Responsibility in Sexual Encounters

Indiana University-Purdue University Indianapolis (IUPUI)%%%%Sexting has been linked to a range of sexual behaviors, including sexual assault; however, the mechanism through which sexting increases the risk for sexual assault is unknown. One explanation for the role of sexting in sexual assault could be due to gender differences in sexting and sexual communication. The current study examined men’s and women’s perceptions of sexting as a form of communicating sexual intent and sexual consent, and how sexting influences attributions of responsibility and blame in sexual encounters and alleged sexual assault. Additionally, considering the role of alcohol in sexual assault, the study also examined how both sexting and alcohol influenced individuals’ perceptions of a sexual scenario. Method:Using a factorial vignette design, N = 525 college students (48.6% women; 71% Caucasian) were randomly assigned to one of four vignettes regarding a sexual scenario between a man and woman (John and Jennifer), with sexting and/or alcohol involved. Results: Significant differences in sexting vs. texting conditions were seen for perceptions of sexual intent (F = 147.28, p< .01) and sexual consent (F = 105.86, p< .01). Men were more likely to perceive that sexual consent was exchanged (F = 9.16, p< .01) and to interpret the sext as a consent cue (F = 7.82, p< .01). John was attributed more responsibility/blame across all conditions (F = 154.58, p< .01); however, Jennifer was attributed more blame in the sexting conditions (F = 9.16, p< .01). Conclusion: Results suggest that despite sexting as a signal of sexual interest, there are differences in how men and women perceive sexting as sexual consent, which may influence the risk for sexual assault. Additionally, there are differential effects of sexting for men vs. women, such that women may be judged more harshly for sexting, suggesting evidence of the sexual double standard. Results offer important implications for sexual assault prevention and sexual gender roles.
Stock Return Volatility on Scandinavian Stock Markets and the Banking Industry: Evidence from the Years of Financial Liberalisation and Banking Crisis

This paper investigates the evolution of the (conditional) volatility of returns on three Scandinavian markets (Finland, Norway and Sweden) over the turbulent period of the past decade, namely the overlapping periods of financial liberalisation, drastically changing macroeconomic conditions and banking crisis. We find that even over this relatively turbulent period volatility is in most cases successfully captured by past volatility and shocks to past volatility, ie by a (symmetric) GARCH process. In each country banking crisis has induced regime shifts in (unconditional) volatility. We also find evidence for cross-country volatility spillovers during the banking crisis episodes. The estimated volatility patterns suggest that even though the volatility of returns was of very high magnitude during the years of banking crisis, developments within the banking industry were not reflected in market uncertainty until all the damage had been done and the severe problems afflicting banks began to be realised in full.
Internet Advertising: An Interplay among Advertisers, Online Publishers, Ad Exchanges and Web Users

Internet advertising is a fast growing business which has proved to be significantly important in digital economics. It is vitally important for both web search engines and online content providers and publishers because web advertising provides them with major sources of revenue. Its presence is increasingly important for the whole media industry due to the influence of the Web. For advertisers, it is a smarter alternative to traditional marketing media such as TVs and newspapers. As the web evolves and data collection continues, the design of methods for more targeted, interactive, and friendly advertising may have a major impact on the way our digital economy evolves, and to aid societal development. Towards this goal mathematically well-grounded Computational Advertising methods are becoming necessary and will continue to develop as a fundamental tool towards the Web. As a vibrant new discipline, Internet advertising requires effort from different research domains including Information Retrieval, Machine Learning, Data Mining and Analytic, Statistics, Economics, and even Psychology to predict and understand user behaviours. In this paper, we provide a comprehensive survey on Internet advertising, discussing and classifying the research issues, identifying the recent technologies, and suggesting its future directions. To have a comprehensive picture, we first start with a brief history, introduction, and classification of the industry and present a schematic view of the new advertising ecosystem. We then introduce four major participants, namely advertisers, online publishers, ad exchanges and web users; and through analysing and discussing the major research problems and existing solutions from their perspectives respectively, we discover and aggregate the fundamental problems that characterise the newly-formed research field and capture its potential future prospects.
Human Bisphenol A Exposure and the “Diabesity Phenotype”

Bisphenol A (BPA), a known endocrine disruptor, is a food contaminant suspected of being a contributing factor to the present-day increase in obesity, diabetes, and cardiovascular disease. This issue is of increasing interest in the field of diabetes research and has become a matter of concern for regulatory agencies and food industries. Recently, the number of studies involving BPA has increased exponentially, but there are still many gaps in the knowledge of the relationship between actual BPA exposure and cardiometabolic risk and of the modalities of food intake exposure, all of which prevents sound judgments concerning the risks to human health. This review focuses on the association between human exposure to BPA and obesity, thyroid function, diabetes, insulin resistance, metabolic syndrome, cardiovascular diseases, and BPA content in food. Many cross-sectional studies support, sometimes contradictorily, an adverse effect of BPA exposure on obesity, diabetes, and cardiovascular diseases. Few prospective studies support an adverse effect of BPA exposure on such pathologies. Moreover, no intervention studies have been conducted to evaluate the causality of such associations. This is mainly due to lack of an appropriate database of BPA content in foods, thus hindering any estimation of the usual dietary BPA intake.
Carrier States in Ferromagnetic Semiconductors and Diluted Magnetic Semiconductors—Coherent Potential Approach—

The theoretical study of magnetic semiconductors using the dynamical coherent potential approximation (dynamical CPA) is briefly reviewed. First, we give the results for ferromagnetic semiconductors (FMSs) such as EuO and EuS by applying the dynamical CPA to the s-f model. Next, applying the dynamical CPA to a simple model for A1−xMnxB-type diluted magnetic semiconductors (DMSs), we show the results for three typical cases to clarify the nature and properties of the carrier states in DMSs. On the basis of this model, we discuss the difference in the optical band edges between II-V DMSs and III-V-based DMSs, and show that two types of ferromagnetism can occur in DMSs when carriers are introduced. The carrier-induced ferromagnetism of Ga1−xMnxAs is ascribed to a double-exchange (DE)-like mechanism realized in the magnetic impurity band/or in the band tail.