Miracle-dz/UniFAR-FTUs huggingface dataset:
A NUMERICAL STUDY OF THE DIURNAL VARIATION OF METEOROLOGICAL PARAMETERS IN THE PLANETARY BOUNDARY LAYER

Abstract The diurnal variation of various meteorological parameters in the Planetary Boundary Layer at different latitudes was studied adopting the basic framework of the simple one dimensional model of Estoque and modifying it in the light of the latest theories of atmospheric turbulence. Following are the results concerning the variation of wind: i) The phase angle of the diurnal wind speed wave shifts with height, the rate of shift varying with latitude. The latter is negative at latitudes north of 30°N. , zero at about 30°N. , and becomes positive south of 30°N. ii) Low level wind maximum occurs before midnight in midlatitudes, slightly after midnight at 30°N. , at sunrise at 17.5°N. , and later farther south. iii) The amplitude of the diurnal wind speed wave increases from north to south, reaches a maximum a little below 3O°N. , and then decreases rapidly. The super-geostrophic winds are strongest between 40°N. and 20°N. , suggesting that these latitudes are more favorable for the occurrence of low level j.
Fluctuating force-coupling method for interacting colloids

Brownian motion plays an important role in the dynamics of colloidal suspensions. It affects rheological properties, influences the self-assembly of structures, and regulates particle transport. While including Brownian motion in simulations is necessary to reproduce and study these effects, it is computationally intensive due to the configuration dependent statistics of the particles’ random motion. We will present recent work that speeds up this calculation for the force-coupling method (FCM), a regularized multipole approach to simulating suspensions at large-scale. We show that by forcing the surrounding fluid with a configurationindependent, white-noise stress, fluctuating FCM yields the correct particle random motion, even when higherorder terms, such as the stresslets, are included in the multipole expansion. We present results from several simulations demonstrating the effectiveness of this approach for modern problems in colloidal science and discuss open questions such as the extension of fluctuating FCM to dense suspensions.
A Luenberger-like observer for nonlinear systems

A state observer is proposed for nonlinear continuous time systems which extends the well known Luenberger observer. In particular, on the basis of simple assumptions on the regularity of the system equations (observability and the global Holder condition for suitable functions), which are generally satisfied for physically meaningful dynamic systems, the global asymptotic convergence of the estimated state towards the true state is shown. Finally, some examples of applications are also reported showing the effectiveness of the proposed observer.
Association between Phosphorylated AMP-Activated Protein Kinase and Acetyl-CoA Carboxylase Expression and Outcome in Patients with Squamous Cell Carcinoma of the Head and Neck

Background Epidemiological studies have indicated that impaired glucose metabolism may increase the risk of squamous cell carcinoma of the head and neck (SCCHN). AMP-activated protein kinase (AMPK) regulates glucose and lipid metabolism via the phosphorylation and subsequent inactivation of its downstream target acetyl-CoA carboxylase (ACC). Thus, we analyzed the expression of pAMPK and its downstream target phosphorylated acetyl-CoA carboxylase (pACC), as well as their impact on the survival of patients with resected SCCHN. Methods One hundred eighteen patients with surgically resected SCCHN were enrolled. Immunohistochemical (IHC) staining for pAMPK and pACC was performed using tissue microarrays of operative specimens of SCCHN. The expression was divided into two or three groups according to the IHC score [pAMPK: negative (0), positive (1–3); pACC: negative (0), low expression (1, 2), and high expression (3)]. Statistical analysis was performed to determine the association of pAMPK expression with clinicopathological features and pACC and pErk expression. Results The positive rates of pAMPK and pACC expression were 64.4% (76/118) and 68.6% (81/118), respectively. pAMPK was significantly higher in patients aged younger than 60 years (P = 0.024; χ2test) and those with early-stage (T1/T2; P = 0.02; χ2 test) and oral cavity (P = 0.026; Fisher’s exact test) tumors. In multivariate analysis, pAMPK expression was not significantly correlated with overall survival (OS) (adjusted hazard ratio [HR]: 0.66; 95% confidence interval [CI]: 0.35–1.23), whereas high pACC expression was independently associated with worse OS in node-positive patients (adjusted HR: 17.58; 95% CI: 3.50–88.18). Conclusions Strong expression of pACC was found to be an independent prognostic marker for patients with node-positive SCCHN. Our results suggest that pACC may play a role in tumor progression of SCCHN and may help to identify patient subgroups at high risk for poor disease outcome.
Situational Context Directs How People Affectively Interpret Robotic Non-Linguistic Utterances

This paper presents an experiment investigating the influence that a situational context has upon how people affectively interpret Non-Linguistic Utterances made by a social robot. Subjects were presented five video conditions showing the robot making both a positive and negative utterance, the robot being subject to an action (e.g. receiving a kiss, or a slap), and then two videos showing the combination of the action and the robot reacting with both the positive and negative utterances. For each video an affective rating of valence was provided based upon how the subjects thought the robot felt given what had happened in the video. This was repeated for 5 different action scenarios. Results show that the affective interpretation of an action appears to override that of an utterance, regardless of the affective charge of the utterance. Furthermore, it is shown that if the meaning of the action and utterance are aligned, the overall interpretation is amplified. These findings are considered with respect to the practical use of utterances during social HRI.
Activation of REG family proteins in colitis

Abstract Aims. To do a genome-wide gene expression study of active and inactive ulcerative colitis and Crohn's disease (inflammatory bowel disease – IBD) and examine the most differentially expressed genes. As the study showed an extreme upregulation of all regenerating islet-derived genes (REG proteins) in active IBD, we further studied the expression of REGs on protein level in active and inactive IBD, as well as in non-IBD (pseudomembranous) colitis. Methods. Microarray analysis was done on a total of 100 pinch biopsy samples from healthy controls and patients with Crohn's disease or ulcerative colitis. Tissue samples from IBD and pseudomembranous colitis were examined with routine histology and immunohistochemical analysis for REGIα, REGIV, DEFA6, and serotonin. Results. REG mRNAs were up to 83 times overexpressed in diseased mucosa compared with mucosa from healthy individuals. REGIα and REGIV were overexpressed at immunohistochemistry and located to different mucosal cell types. REGIα was expressed in basal half of crypts, REGIV in mid and outer parts of crypts and in surface epithelium and seems to be stored in, and secreted from, goblets. Pseudomembranous colitis samples showed similar staining patterns, and some IBD samples stained REG positive without inflammation on routine histology. Conclusions. All REG family mRNAs are upregulated in IBD. REGIα and REGIV have different cellular localization, possibly reflecting different biological functions. REG protein expression also in pseudomembranous colitis shows that REG family proteins are regulated in inflammatory injury and repair, not specifically for IBD as previously thought.
Evaluating alternative theoretical models for examining citizen centric adoption of e‐government

Purpose – The purpose of this paper is to empirically examine the performance of the alternative IS/IT adoption models used more frequently in the citizen centric adoption of e‐government systems. Such analysis will not only provide a trend about the models and subsequent constructs being utilized in this area of research but also guides us toward laying a foundation for the formulation of an alternative integrated model for citizen centric adoption of e‐government services.Design/methodology/approach – The relevant secondary data from 87 research studies on citizen centric e‐government services were analysed to examine the performance of some of the most frequently used alternative models (e.g. technology acceptance model (TAM), diffusion of innovation|innovation diffusion theory (DOI|IDT), DeLone and McLean IS success model, unified theory of acceptance and use of technology (UTAUT), and theory of planned behaviour (TPB)) of IS/IT adoption in this area of research.Findings – The findings of this researc.
A good-quality breakfast is associated with better mental health in adolescence

Abstract Objective Breakfast consumption has been associated with better mental health in adulthood, but the relationship between breakfast and mental health in adolescence is less well known. The aims of the present study were to evaluate breakfast quality in a cohort of adolescents and to investigate associations with mental health. Design Cross-sectional population-based study. Breakfast quality was assessed by intake of core food groups at breakfast, as determined from 3 d food diaries. Mental health was assessed using the Child Behaviour Checklist (CBCL), with higher scores representing poorer behaviour. Setting The Western Australian Pregnancy Cohort (Raine) Study, Perth, Western Australia. Subjects Eight hundred and thirty-six males and females aged between 13 and 15 years. Results Mean mental health score as assessed by the CBCL was 45·24 (sd 11·29). A high-quality breakfast consisting of at least three food groups was consumed by 11 % of adolescents, while 7 % of adolescents did not consume any items from core food groups on average over the 3 d period. The two most common core food groups consumed at breakfast in this population were dairy products followed by breads and cereals. For every additional food group eaten at breakfast, the associated total mental health score decreased by 1·66 (95 % CI −2·74, −0·59) after adjustment for potential confounding factors, representing an improvement in mental health score. Conclusion These findings support the concept that breakfast quality is an important component in the complex interaction between lifestyle factors and mental health in early adolescence.
A Structural Equation Model: Thailand’s International Tourism Demand for Tourist Destination

Structural equation modelling (LISREL 8) was used to test the causal relationships between tourist travel motivations (travel cost satisfaction and tourist demographics) and tourist destination (tourism product, tourism product attributes, and tourism product management). A survey containing Likert-type scales was used in collecting data from 203 international tourists who had travelled to Thailand. Using factor analysis, dimensions were identified for scales used in the study: travel cost satisfaction, tourist demographics, tourism product, tourism product attributes, and tourism product management. Results indicated that the travel cost satisfaction of international tourists had a positive influenced on tourism product attributes at 0.07 (t=1.96) with statistics significant at the level of 0.05. Also the travel cost satisfaction had a positive influence on tourism product management at 0.13 (t=4.02) with statistics significant at the level of 0.05. And the tourist demographics had a positive influenced on tourism product at 0.11(t=3.47) with statistic significant at the level of 0.05. As well as tourist demographics, which had a positive influenced on tourism management at 0.11 (t=3.57) with statistics significant at the level of 0.05. The results of the research suggested that if the tourist destinations in Thailand are improved in quality then not only will international tourist revisit Thailand but also the numbers of tourists travelling to Thailand will increase.
An RNAi screen identifies KIF15 as a novel regulator of the endocytic trafficking of integrin

ABSTRACT &agr;2&bgr;1 integrin is one of the most important collagen-binding receptors, and it has been implicated in numerous thrombotic and immune diseases. &agr;2&bgr;1 integrin is a potent tumour suppressor, and its downregulation is associated with increased metastasis and poor prognosis in breast cancer. Currently, very little is known about the mechanism that regulates the cell-surface expression and trafficking of &agr;2&bgr;1 integrin. Here, using a quantitative fluorescence-microscopy-based RNAi assay, we investigated the impact of 386 cytoskeleton-associated or -regulatory genes on &agr;2 integrin endocytosis and found that 122 of these affected the intracellular accumulation of &agr;2 integrin. Of these, 83 were found to be putative regulators of &agr;2 integrin trafficking and/or expression, with no observed effect on the internalization of epidermal growth factor (EGF) or transferrin. Further interrogation and validation of the siRNA screen revealed a role for KIF15, a microtubule-based molecular motor, as a significant inhibitor of the endocytic trafficking of &agr;2 integrin. Our data suggest a novel role for KIF15 in mediating plasma membrane localization of the alternative clathrin adaptor Dab2, thus impinging on pathways that regulate &agr;2 integrin internalization.
A Program Model Based Regression Test Selection Technique for Object-Oriented Programs

We propose a regression test selection technique that is based on analysis of source code of an object-oriented program. First we construct a System dependency graph model of the original program from the source code. When some modification is executed in a program, the constructed model is updated to reflect the changes. Our approach in addition to capturing control and data dependencies represents the dependencies arising from object-relations. The test cases that exercise the affected model elements in the program model are selected for regression testing. In our approach System Design Graph representation will be used for regression test selection for analyzing and comparing the code changes of original and modified program. Empirical studies carried out by us show that our technique selects on an average of 26.36. % more fault-revealing test cases compared to a Control Dependence Graph based technique while incurring about 37.34% increase in regression test suite size.
Intramembrane Bis-Heme Motif for Transmembrane Electron Transport Conserved in a Yeast Iron Reductase and the Human NADPH Oxidase*

A plasma membrane iron reductase, required for cellular iron acquisition by Saccharomyces cerevisiae, and the human phagocytic NADPH oxidase, implicated in cellular defense, contain low potential plasma membrane b cytochromes that share elements of structure and function. Four critical histidine residues in the FRE1 protein of the iron reductase were identified by site-directed mutagenesis. Individual mutation of each histidine to alanine eliminated the entire heme spectrum without affecting expression of the apoprotein, documenting the specificity of the requirement for the histidine residues. These critical residues are predicted to coordinate a bis-heme structure between transmembrane domains of the FRE1 protein. The histidine residues are conserved in the related gp91phox protein of the NADPH oxidase of human granulocytes, predicting the sites of heme coordination in that protein complex. Similarly spaced histidine residues have also been implicated in heme binding by organelle b cytochromes with little overall sequence similarity to the plasma membrane b cytochromes. This bis-heme motif may play a role in transmembrane electron transport by distinct families of polytopic b cytochromes.
High-Content, Image-Based Screening for Drug Targets in Yeast

Background Drug discovery and development are predicated on elucidation of the potential mechanisms of action and cellular targets of candidate chemical compounds. Recent advances in high-content imaging techniques allow simultaneous analysis of a range of cellular events. In this study, we propose a novel strategy to identify drug targets by combining genetic screening and high-content imaging in yeast. Methodology In this approach, we infer the cellular functions affected by candidate drugs by comparing morphologic changes induced by the compounds with the phenotypes of yeast mutants. Conclusions Using this method and four well-characterized reagents, we successfully identified previously known target genes of the compounds as well as other genes involved with functionally related cellular pathways. This is the first demonstration of a genetic high-content assay that can be used to identify drug targets based on morphologic phenotypes of a reference mutant panel.
Optimising Agile Social Media Analysis

Agile social media analysis involves building bespoke, one-off classification pipelines tailored to the analysis of specific datasets. In this study we investigate how the DUALIST architecture can be optimised for agile social media analysis. We evaluate several semi-supervised learning algorithms in conjunction with a Na ive Bayes model, and show how these modifications can improve the performance of bespoke classifiers for a variety of tasks on a large range of datasets.
Effects of natural blend of essential oil on growth performance, blood biochemistry, cecal morphology, and carcass quality of broiler chickens

The study evaluated the effect of a novel commercial preparation of natural blend of essential oils from basil, caraway, laurel, lemon, oregano, sage, tea, and thyme (Tecnaroma Herbal Mix PL) on growth performance, blood biochemistry, cecal morphology, and carcass quality of broilers. Six nutritionally adequate wheat and soybean-based diets were generated by the addition of Tecnaroma Herbal Mix PL at 0, 100, 200, 300, 400, and 500 g/t of feed. The diets were fed as crumbs in the starter phase (d 0–10) and as pellets during the grower (d 10–24) and finisher (d 24–42) phases. Nine hundred sixty 1-d-old chicks were allocated to the 6 dietary treatments each having 8 replicate pens with 20 birds per pen. The data obtained were analyzed using ANOVA with a P < 0.05 level of significance. Birds fed diets supplemented with Tecnaroma Herbal Mix PL had significantly heavier BW and higher (P < 0.05) weight gain and had improved (P < 0.05) feed to gain ratio compared with the control group during grower phase and overall performance. The blood biochemistry results showed no differences (P > 0.05) between treatments. The carcass weight, breast weight, and relative percentage of breast meat increased (P < 0.05) when diets were supplemented with Tecnaroma Herbal Mix PL compared with that from birds fed the control diet. The inclusion level of 300 g of Tecnaroma Herbal Mix PL/t of feed was optimum for enhancing breast meat yield and nutrient utilization as indicated by increased (P < 0.05) cecal villus surface area.
The Informational Role of Options Trading Volume in the Australian Index Options Markets

The contemporaneous call options volume have a significant strong positive feedback effect on the implied volatility, but the contemporaneous feedback effect of volume on the TARCH volatility is insignificant. The contemporaneous feedback effects from the implied volatility and the TARCH volatility to the call options volume are positive, significant and strong. Our results indicate that market forces, such as speculation and arbitrage, in the S&P/ASX 200 call options market operate effectively to produce quick and strong interactions between call options volume and volatility. The bi-directional causality (or feedback) between call options volume and implied volatility or TARCH volatility. The direction of causality from implied volatility or TARCH volatility to call options volume is significant, implying lagged volatilities cause current volume to change. The causality from call options volume to implied volatility or TARCH volatility exists but is relatively weak. Our results indicate that lagged volatility values are good predictors of volume levels, but lagged volume levels are weak predictors of implied volatility and TARCH volatility values.
Sind es die Erwerbsunterbrechungen?: ein Erklärungsbeitrag zum Lohnunterschied zwischen Frauen und Männern in Deutschland (Is it the employment interruptions? * a contribution to explaining the wage differentials between men and women in Germany)

"This study makes a contribution to explaining the gender-specific wage differentials in western Germany. On the basis of the IAB employment survey and the IAB additional survey I, we estimate the wages of men and women using flexible wage equations which take into consideration the entire employment biography including the type and duration of each past employment interruption. Thus, we can differentiate between the short-term and the long-term wage effects of unemployment, formal parental leave as well as of other interruptions, and determine their contribution to explaining the gender-specific wage differential. Not only is the work experience of men and women remunerated differently on the labour market; the wages of men and women are also affected differently by past employment interruptions. The negative wage effects of statutory parental leave and of further work interruptions of women contribute considerably to the gender-specific wage differential. " (Author's abstract, IAB-Doku) ((en))
Iterative estimating equations: Linear convergence and asymptotic properties

We propose an iterative estimating equations procedure for analysis of longitudinal data. We show that, under very mild conditions, the probability that the procedure converges at an exponential rate tends to one as the sample size increases to infinity. Furthermore, we show that the limiting estimator is consistent and asymptotically efficient, as expected. The method applies to semiparametric regression models with unspecified covariances among the observations. In the special case of linear models, the procedure reduces to iterative reweighted least squares. Finite sample performance of the procedure is studied by simulations, and compared with other methods. A numerical example from a medical study is considered to illustrate the application of the method.