Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety of Lansoprazole in the Treatment of Gastroesophageal Reflux Disease in Children

Objectives: To evaluate the safety of lansoprazole in children between 1 and 11 years of age. Methods: In a phase I/II, open‐label, multicenter (11 sites) study, children with symptomatic gastroesophageal reflux disease (GERD), erosive esophagitis (≥grade 2), and/or esophageal pH < 4 for > 4.2% of the 24‐hour period were assigned, on the basis of body weight, to lansoprazole 15 mg (≤30 kg) or 30 mg (>30 kg) once daily for 8 to 12 weeks. At the discretion of the investigator, the dosage of lansoprazole was increased up to 60 mg daily in children who continued to be symptomatic after 2 weeks of treatment. Safety for all study participants was monitored by adverse event reports and laboratory evaluations. Results: Sixty‐six children were enrolled in the study and were included in the safety analysis. Throughout the treatment period, no child discontinued therapy because of an adverse event and no. clinically significant changes in laboratory values were observed. Three of the 32 children (9%) who received lansoprazole 15 mg once daily (mean exposure 50.3 days) and 6 of the 34 children (18%) who received the 30 mg once‐daily dose (mean exposure 49.4 days) experienced one or more treatment‐related adverse events before any dose increase. The three children in the lansoprazole 15 mg treatment group were treated with doses of 0.6 mg to 1.2 mg/kg/day; those in the lansoprazole 30 mg treatment group were treated with doses of 0.7 mg to 0.9 mg/kg/day. Only one child experienced a new treatment‐related adverse event after an increase in lansoprazole dose to 1.3 mg/kg/day. Treatment‐related events experienced by two or more children were: constipation (lansoprazole 15 mg QD, two children; lansoprazole 30 mg QD, one child), and headache (lansoprazole 30 mg QD, two children). Mean fasting serum gastrin levels were significantly increased from 58.0 pg/mL at baseline to 112.4 pg/mL at week 2 and 121.9 pg/mL at the final visit (P ≤ 0.001 for each comparison). However, the median fasting serum gastrin levels at the week 2 and the final visit were within the normal range (25‐111 pg/mL). Conclusion: Lansoprazole, when administered on the basis of body weight in children between 1 and 11 years of age, is safe and well‐tolerated.
Sexual problems in medical practice.

Find loads of the sexual problems in medical practice book catalogues in this site as the choice of you visiting this page. You can also join to the website book library that will show you numerous books from any types. Literature, science, politics, and many more catalogues are presented to offer you the best book to find. The book that really makes you feels satisfied. Or that's the book that will save you from your job deadline.
The Very Large G-Protein-Coupled Receptor VLGR1: A Component of the Ankle Link Complex Required for the Normal Development of Auditory Hair Bundles

Sensory hair bundles in the inner ear are composed of stereocilia that can be interconnected by a variety of different link types, including tip links, horizontal top connectors, shaft connectors, and ankle links. The ankle link antigen is an epitope specifically associated with ankle links and the calycal processes of photoreceptors in chicks. Mass spectrometry and immunoblotting were used to identify this antigen as the avian ortholog of the very large G-protein-coupled receptor VLGR1, the product of the Usher syndrome USH2C (Mass1) locus. Like ankle links, Vlgr1 is expressed transiently around the base of developing hair bundles in mice. Ankle links fail to form in the cochleae of mice carrying a targeted mutation in Vlgr1 (Vlgr1/del7TM), and the bundles become disorganized just after birth. FM1-43 [N-(3-triethylammonium)propyl)-4-(4-(dibutylamino)styryl) pyridinium dibromide] dye loading and whole-cell recordings indicate mechanotransduction is impaired in cochlear, but not vestibular, hair cells of early postnatal Vlgr1/del7TM mutant mice. Auditory brainstem recordings and distortion product measurements indicate that these mice are severely deaf by the third week of life. Hair cells from the basal half of the cochlea are lost in 2-month-old Vlgr1/del7TM mice, and retinal function is mildly abnormal in aged mutants. Our results indicate that Vlgr1 is required for formation of the ankle link complex and the normal development of cochlear hair bundles.
Attachment representations, parental differential treatment and sibling relationships.

The purpose of this review is to examine the literature on siblings and sibling relationships. To outline the importance of this under-researched field the review details the link between sibling relationship quality and individual psychosocial outcome. Initial research into the area started with investigations of the influence of structural variables and temperament on sibling relationship quality but found that they explained only a small proportion of the variance in sibling relationship quality. Associations between sibling relationships and peer relationships have been found but as yet no studies investigated the direction of causality. The nature of the parent-child relationship has been found to be a strong predictor of the quality of the sibling relationship. Further investigations have discovered that how parents treat children differently is not only related to the quality of the sibling relationship but also to psychosocial adjustment. Where greater differential experience is perceived it is associated with poorer sibling relationship quality and more problem behaviours.
Hypersensitivity reactions to antineoplastic agents: an overview

Hypersensitivity reactions to antineoplastic agents are defined as unexpected reactions with signs and symptoms inconsistent with known toxicity of antineoplastic drugs. These reactions are uncommon and usually associated with certain antineoplastic categories, such as taxanes, platinum-containing compounds, epipodofyllotoxins, asparaginase, procarbazine and, more rarely, with doxorubicin and 6-mercaptopurine. The mechanisms that are responsible for hypersensitivity reactions are unclear and vary between agents. Symptoms of these reactions range from mild skin rashes to more severe reactions, such as arthralgia, respiratory arrest or even death in some cases. Once hypersensitivity reactions are observed, basic principles that allow their management and possible continuance and completion of the regimen should be followed.
Using wikis for organizational learning: functional and psycho‐social principles

Purpose – The purpose of this paper is to aim to identify principles that make wikis an effective application when they are used within an organization. Those principles are supposed to make wikis a successful instrument for organizational learning.Design/methodology/approach – The article makes a distinction between functional and psycho‐social principles and emphasizes their impact on organizational learning.Findings – The functional principles (quick and easy editing; wikilinks; no hierarchical hypertext structure; revision and topicality; collaborative product; scalability and flexibility) may be regarded as the constitutive attributes of wikis. The psycho‐social principles (openness; self‐organization; autonomy; interest and personal relevance; diversity; serendipity effect) are not directly associated with wikis as a tool, but refer to the application context.Originality/value – The article explains the functional and psycho‐social principles in detail. This will help organizations and knowledge‐man.
Speech and Language Outcomes of Cochlear Implantation in Children With Isolated Auditory Neuropathy Versus Cochlear Hearing Loss

Objective Children with auditory neuropathy (AN) have variable hearing on pure tone testing, and the presence of speech and language delays often play a major role in the decision to offer cochlear implantation (CI) in this population. Despite this fact, the speech and language outcomes in this group after CI are not well described. This study compares speech and language outcomes after CI in a subset of the pediatric AN population that does not have a confounding cognitive disorder with those of their peers with cochlear hearing loss (CoHL). Study Design Retrospective chart review. Setting Tertiary referral center. Patients Seventeen pediatric patients with AN who received a CI and a group of children with CoHL who received a CI were the subjects of this study. The 2 groups demonstrated similar ages at implant. Children with cognitive delays were excluded from each group. Intervention Cochlear implantation. Main Outcome Measures All subjects were evaluated preoperatively and postoperatively with standardized age appropriate speech and language measures, including the Expressive Vocabulary Test (EVT), Peabody Picture Vocabulary Test (PPVT), and Preschool Language Scale (PLS). Results There was no significant difference between the groups on age of activation of the CI. Children with a diagnosis of AN had a significantly lower unaided pure tone average preoperatively as compared with children with cochlear hearing loss; however, there was no significant difference between the groups on either their preimplantation or postimplantation speech and language scores. Conclusion Children with a diagnosis of AN without associated cognitive or developmental disorders have speech and language outcomes comparable to other children who received a CI.
LSU Digital Commons LSU Digital Commons More than 1000 ultraconserved elements provide evidence that More than 1000 ultraconserved elements provide evidence that turtles are the sister group of archosaurs turtles are the sister group of archosaurs

We present the ﬁrst genomic-scale analysis addressing the phylogenetic position of turtles, using over 1000 loci from representatives of all major reptile lineages including tuatara. Previously, studies of morphological traits posi-tioned turtles either at the base of the reptile tree or with lizards, snakes and tuatara (lepido-saurs), whereas molecular analyses typically allied turtles with crocodiles and birds (archo-saurs). A recent analysis of shared microRNA families found that turtles are more closely related to lepidosaurs. To test this hypothesis with data from many single-copy nuclear loci dis-persed throughout the genome, we used sequence capture, high-throughput sequencing and published genomes to obtain sequences from 1145 ultraconserved elements (UCEs) and their vari-able ﬂanking DNA. The resulting phylogeny provides overwhelming support for the hypothesis that turtles evolved from a common ancestor of birds and crocodilians, rejecting the hypothesized relationship between turtles and lepidosaurs. from which we designed capture probes, owing to slight adjustments to matching and ﬁltering algorithms, we only recover ca 98% of these UCEs when re-screening these genomic sequences.
Novel Norovirus in Dogs with Diarrhea

To identify the prevalence and genetic variability of noroviruses in dogs, we tested fecal samples by using reverse transcription–PCR. We found canine norovirus in 40% and 9% of dogs with and without diarrhea, respectively. The virus was genetically unrelated to other noroviruses and constitutes a tentative new genogroup.
Using MapReduce for Large-Scale Medical Image Analysis

In this paper, MapReduce is used to speed up and make possible three large-scale medical image processing use-cases: (i) parameter optimization for lung texture classification using support vector machines (SVM), (ii) content-based medical image indexing, and (iii) three-dimensional directional wavelet analysis for solid texture classification.
Adequacy of expressed breast milk for early gwoth of preterm infants.

Poor weight gain observed in preterm infants who were fed expressed breast milk compared with those fed a cows' milk formular prompted a detailed study of early postnatal growth in preterm infants fed these two milks. 68 infants were divided into two categories by gestational age at birth (i) 28-32 weeks (n=28), (ii) 33-36 weeks (n=40). They were randomly allocated to a feed of expressed breast milk or a milk formula (Ostermilk 1). Rates of weight gain, linear growth, and head circumference growth were evaluated over two periods: birth-1 month, 1-2 months. The younger group who were fed breast milk showed slower overall growth rates over the first month than those fed formula. In the second month, and for the older infants over both of the 2-monthly periods, growth rates were similar in the two feeding regimens. It is concluded that expressed breast milk is inadequate for the growth of very immature preterm infants during early postnatal life.
Tracking control of multi-input affine nonlinear dynamical systems with unknown nonlinearities using dynamical neural networks

The purpose of this paper is to design and rigorously analyze a tracking controller, based on a dynamic neural network model for unknown but affine in the control, multi input nonlinear dynamical systems, Lyapunov stability theory is used to guarantee a uniform ultimate boundedness property for the tracking error, as well as of all other signals in the closed loop. The controller derived is smooth. No a priori knowledge of an upper bound on the "optimal" weights and modeling errors is required. Simulation studies are used, to illustrate and clarify the theoretical results.
Endometrial cancer and microsatellite instability status

Abstract Microsatellite instability (MSI) is an important factor in the development of various cancers as an identifier of a defective DNA mismatch repair system. The objective of our study was to define the association between microsatellite instability status and traditional clinicopathologic characteristics of endometrioid type adenocarcinoma. Material and methods: MSI status of endometrial cancer was examined by employing the Promega MSI Analysis System. This system uses 5 mononucleotide markers to identify MSI in tumour and normal tissue DNA (BAT-25, BAT-26, NR-21, NR-24, and MONO-27), and 2 pentanucleotide markers (Penta C and Penta D) for specimen identification. In this study, we investigated MSI status in 109 endometrial carcinomas. Results and conclusions: One hundred (92%) of 109 endometrial cancers showed endometrioid type histology and only 9 (8%) non-endometrioid type. MSI-high was found in 17% (17/100) of endometrioid type adenocarcinomas, in 0% (0/9) of non-endometrioid carcinomas. Selected clinicopathologic parameters for endometrioid type adenocarcinomas were compared to the MSI status which was separated into two groups – MSI-high and MSI stable. The results showed that MSI-high status was related to clinicopathologic parameters such as deep myometrial invasion and higher histologic grade in endometrioid type adenocarcinomas.
International Journal of C 2009 Institute for Scientific Numerical Analysis and Modeling Computing and Information a Computational Scheme for Options under Jump Diffusion Processes

In this paper we develop two novel numerical methods for the partial integral differential equation arising from the valuation of an option whose underlying asset is governed by a jump diffusion process. These methods are based on a fitted finite volume method for the spatial discretization, an implicit-explicit time stepping scheme and the Crank-Nicolson time stepping method. We show that the discretization methods are unconditionally stable in time and the system matrices of the resulting linear systems are M-matrices. The resulting linear systems involve products of a dense matrix and vectors and an Fast Fourier Transformation (FFT) technique is used for the evaluation of these products. Furthermore, a splitting technique is proposed for the solution of the discretized system arising from the Crank-Nicolson scheme. Numerical results are presented to show the rates of convergence and the robustness of the numerical method.
Systematic review with network meta-analysis: Comparative efficacy of oral nucleos(t)ide analogues for the prevention of chemotherapy-induced hepatitis B virus reactivation

Objectives Currently, no consensus exists regarding the optimal oral prophylactic regimens for hepatitis B surface antigen seropositive patients undergoing chemotherapy. We aimed to compare the efficacy of oral nucleos(t)ide analogues (NAs), including lamivudine, entecavir, adefovir, telbivudine and tenofovir, for the prevention of chemotherapy-induced hepatitis B virus (HBV) reactivation and its related morbidity and mortality in patients with chronic HBV (CHB) infection. Results Fifty-two eligible articles consisting of 3892 participants were included. For HBV reactivation, prophylactic treatment with NAs were all significantly superior to no prophylaxis, with odds ratio (OR) from 0.00 (95% confidence interval [CI] 0.00~0.04) for the most effective intervention (tenofovir) to 0.10 (95% CI 0.06~0.14) for the least effective intervention (lamivudine). For secondary outcomes, prophylaxis with NAs also significantly outperformed observation. The results suggested that entecavir reduced the risk of HBV related hepatitis (predicted probability, 83%), HBV related death (68%) and all causes of hepatitis (97%) most efficaciously. It ranked second in decreasing all causes of death (34%). Materials and Methods PubMed, Embase and Cochrane Library database were searched for controlled trials up to March 31, 2015. Primary outcome was the incidence of HBV reactivation. Secondary outcomes included the incidence of HBV-related hepatitis and death, all causes of hepatitis and death. Network meta-analysis combined direct and indirect evidence to estimate ORs for the clinical outcomes. A mean ranking and the probability of optimal therapeutic regime was obtained for each treatment based on clinical outcomes. Conclusions Available evidence suggests that prophylatic therapy with tenofovir and entecavir may be the most potent interventions in prevention of HBV reactivation and HBV-related morbidity and mortality for CHB infection patients undergoing chemotherapy.
Digging deeper into cluster system logs for failure prediction and root cause diagnosis

As the sizes of supercomputers and data centers grow towards exascale, failures become normal. System logs play a critical role in the increasingly complex tasks of automatic failure prediction and diagnosis. Many methods for failure prediction are based on analyzing event logs for large scale systems, but there is still neither a widely used one to predict failures based on both non-fatal and fatal events, nor a precise one that uses fine-grained information (such as failure type, node location, related application, and time of occurrence). A deeper and more precise log analysis technique is needed. We propose a three-step approach to draw out event dependencies and to identify failure-event generating processes. First, we cluster frequent event sequences into event groups based on common events. Then we infer causal dependencies between events in each event group. Finally, we extract failure rules based on the observation that events of the same event types, on the same nodes or from the same applications have similar operational behaviors. We use this rich information to improve failure prediction. Our approach semi-automates diagnosing the root causes of failure events, making it a valuable tool for system administrators.
Reflecting on the Use of Sonification for Network Monitoring

In Security Operations Centres (SOCs), computer networks are generally monitored using a combination of anomaly detection techniques, Intrusion Detection Systems (IDS) and data presented in visual and text-based forms. In the last two decades significant progress has been made in developing novel sonification systems to further support network monitoring tasks. A range of systems has been proposed in which sonified network data is presented for incorporation into the network monitoring process. Unfortunately, many of these have not been sufficiently validated and there is a lack of uptake in SOCs. In this paper, we describe and reflect critically on the shortcomings of traditional network-monitoring methods and identify the key role that sonification, if implemented correctly, could play in improving current monitoring capabilities. The core contribution of this position paper is in the outline of a research agenda for sonification for network monitoring, based on a review of prior research. In particular, we identify requirements for an aesthetic approach that is suitable for continuous real-time network monitoring; formalisation of an approach to designing sonifications in this space; and refinement and validation through comprehensive user testing.
Photocatalytic reduction of carbon dioxide to methanol and formic acid by graphene-TiO2

Graphene-TiO2 was obtained by reduction of graphite oxide by the hydrothermal method. Using photocatalytic activity to reduce carbon dioxide to methanol and formic acid was investigated in this study. The results show that the graphene loading affects the absorption of light in the visible light region. A larger surface area can also improve the catalytic activity. The largest yield of methanol and formic acid, under light of 365 nm, can reach 160 and 150 μmol g−1, respectively, with 8.5% graphene loading. An increase in graphene loading can enhance photocatalytic performance, but too much will also decrease the reduction efficiency by shielding the light from reaching the catalytic surface. The effect of pH was also investigated. The mechanism of the reaction was also discussed in this study. Implications: Graphene-TiO2 hybrids were prepared by the hydrothermal method. Surface area and visible light adsorption increased with the graphene loading. Increased graphene loading improved the methanol and formic acid production. Too much graphene loading will decrease the reduction efficiency. The effect of pH shows that the HCO3− species prefers the formation of formic acid. The mechanism of the reaction was also discussed in this study.
Minimal functional brain differences between older adults with and without mild cognitive impairment during the stroop

ABSTRACT This investigation compared the neural correlates of inhibition in normal older adults (OAs) and OAs with mild cognitive impairment (MCI). It was hypothesized the MCI group would require a greater amount of resources for inhibition, and therefore display greater functional activation in specific regions of interest (ROIs). Twenty-six OAs without and 17 with MCI completed the Stroop task during functional neuroimaging, and completed additional out-of-scanner neuropsychological measures. During inhibition, there were minimal functional Magnetic Resonance Imaging (fMRI) differences found between groups in a priori specified ROIs and with post-hoc multiple regression analyses. However, these minimal differences did not survive corrected thresholds. Robust differences were found with several tasks of a neuropsychological screening battery. The results of this study suggest only very minimal group differences in fMRI activation during inhibition which may not reliably identify MCI, and this condition may be best detected by traditional neuropsychological techniques.