Miracle-dz/UniFAR-FTUs huggingface dataset:
A Randomized Controlled Trial Comparing Motivational Interviewing in Education to Structured Diabetes Education in Teens With Type 1 Diabetes

OBJECTIVE To compare motivational interviewing–based education (MI) and structured diabetes education (SDE) for improving A1C and psychosocial measures in adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS This study was a 9-month randomized controlled trial comparing MI (n = 21) to SDE (n = 23). Interventions were at baseline (T0) and 3 months (T1), with A1C and psychosocial measures obtained at 6 months (T2) and 9 months (T3). RESULTS Over the 6 months of follow-up, the SDE group had lower adjusted mean A1C value (least squares mean 10.31, SE 0.32) than the MI group (least squares mean 11.35, SE 0.34) (P = 0.03, d = −0.66). There were no differences on any of the psychosocial measures. CONCLUSIONS SDE is effective at improving metabolic control in adolescents with type 1 diabetes. Diabetes educators were proficient in learning MI.
New media interactive advertising vs. traditional advertising

This research explores the effectiveness of interactive advertising on a new medium platform. Like the presence in industry and the media themselves, the academic research stream is fairly new. Our research seeks to isolate the key feature of interactivity from confounding factors and to begin to tease apart those situations for which interactivity might be highly desirable from those situations for which traditional advertising vehicles may be sufficient or superior
Risk Stratification, Systematic Classification, and Anticipatory Management Strategies for Stent Fracture After Percutaneous Pulmonary Valve Implantation

Background— We analyzed the incidence, risk factors and treatment options for stent fracture after percutaneous pulmonary valve (PPV) implantation (PPVI). Methods and Results— After PPVI, 123 patients had chest x-ray in anteroposterior and lateral projection, echocardiography, and clinical evaluation during structured follow-up. Of these 123 patients, 26 (21.1%) developed stent fracture 0 to 843 days after PPVI (stent fracture–free survival at 1 year, 85.1%; at 2 years, 74.5%; and at 3 years, 69.2%). Stent fracture was classified as type I: no loss of stent integrity (n=17); type II: loss of integrity with restenosis on echocardiography (n=8); and type III: separation of fragments or embolization (n=1). In a multivariate Cox regression, we analyzed various factors, of which 3 were associated with a higher risk of stent fracture: implantation into “native” right ventricular outflow tract (P=0.04), no calcification along the right ventricular outflow tract (judged with fluoroscopy, P=0.02), recoil of PPV (qualitatively, PPV diameter in frontal or lateral plane with fully inflated balloon > diameter after balloon deflation, P=0.03). Substernal PPV location, high-pressure post-PPVI dilatation of PPV, pre-PPVI right ventricular outflow tract gradients, and other indicators of PPV compression or asymmetry did not pose increased risk. Patients with type I fracture remain under follow-up. Patients with type II fracture had 2nd PPVI or are awaiting such procedure, and 1 patient with type III fracture required surgical explantation. Conclusion— Stent fracture after PPVI can be managed effectively by risk stratification, systematic classification, and anticipatory management strategies. Serial x-ray and echocardiography are recommended for surveillance.
Comparative Clinical Study of Bactigras and Telfa AMD for Skin Graft Donor-Site Dressing

The Bactigras® paraffin tulle coated with chlorhexidine is normally used for the treatment of donor-site wounds in burn patients who received split-thickness skin grafts in several centers. It has some disadvantages, such as adhesion to wound surfaces and pain from the irritation caused by this dressing. The Telfa AMD®, a non-adherent wound dressing which consists of absorbent cotton fibers impregnated with polyhexamethylene biguanide enclosed in a sleeve of thermoplastic polymers, is a new option for donor-site wound care which causes less adherence to the wound. The purpose of this study was to compare clinical efficacy of these two dressings for the management of donor-site wounds. Thirty-two patients who received split-thickness skin grafts by donor site harvesting from the thigh were enrolled in this study and randomized into two groups receiving either the Bactigras® or the Telfa AMD® wound treatment. Re-epithelialization, pain, infection and cost-effectiveness analyses were compared between both groups. The results showed that there was no significant difference in age, area of donor sites or length of hospital stays between the groups (p > 0.05). However, the day of re-epithelialization (≥90%) was significantly shorter in patients treated with the Telfa AMD® compared to the Bactigras® group (14.00 ± 3.05 vs. 9.25 ± 1.88 days for Bactigras® and Telfa AMD® groups, respectively, p < 0.001). The average pain score was also significantly lower in the Telfa AMD® group (1.57 ± 0.55 vs. 4.70 ± 1.16, p < 0.001). There was no difference in the cost of treatment between the groups (4.64 ± 1.97 vs. 5.72 ± 2.54 USD, p = 0.19). This study indicated that the Telfa AMD® was an effective dressing for the treatment of donor-site wounds.
On Designing UX for Mobile Enterprise Apps

Mobile apps form a special domain for designing user experience (UX). Interactions with the device should be designed such that the time span of the users' actions is shorter than in the desktop space, actions must be simple yet focused. Moreover, interactions must be accomplished with ease, using only a minimal number of finger presses or keystrokes. At the same time, the devices themselves introduce platform specific restrictions and guidelines regarding how UX should be addressed. In this paper, we report results from a study where the contributions of different actors to UX are addressed in the development of mobile enterprise apps. In conclusion, the study indicates that for simplest applications, the best UX specialists are actually the developers who know all platform-specific customs, whereas for more complex apps, special UX role is needed in order to manage the big picture.
The challenges of a high-performance student athlete

To become a top athlete requires time, commitment and carefully planned training. Optimum adaptation to training requires the careful balancing of stress and recovery. The student athlete has to balance all these demands with the additional requirements of an academic programme. This can bring unique stresses and challenges. This research aims to investigate the challenges of combining high-level sport with academic demands. Nine elite student athletes (three females, six males) took part in semi-structured interviews around how the student athletes balanced their training and sporting demands with the academic demands of their course of study. The interviews were transcribed verbatim and analysed using grounded theory. The results suggested that the athletes had each developed their own distinct approach towards training management. Most of the subjects had experienced setback in their study and athletic performance due to overtraining or burnout. The findings highlight the need to empower and educate not only the athlete but also the coach on the impact of overtraining. Key findings from this study were the need for open coach–athlete communication, in-depth planning and the need for adequate recovery.
Mapping Disorder in Polycrystalline Relaxors: A Piezoresponse Force Microscopy Approach

Relaxors constitute a large class of ferroelectrics where disorder is introduced by doping with ions of different size and valence, in order to maximize their useful properties in a broad temperature range. Polarization disorder in relaxors is typically studied by dielectric and scattering techniques that do not allow direct mapping of relaxor parameters, such as correlation length or width of the relaxation time spectrum. In this paper, we introduce a novel method based on measurements of local vibrations by Piezoresponse Force Microscopy (PFM) that detects nanoscale polarization on the relaxor surface. Random polarization patterns are then analyzed via local Fast Fourier Transform (FFT) and the FFT PFM parameters, such as amplitude, correlation radius and width of the spectrum of spatial correlations, are mapped along with the conventional topography. The results are tested with transparent (Pb, La) (Zr, Ti)O3 ceramics where local disorder is due to doping with La3+. The conclusions are made about the distribution of the defects responsible for relaxor behavior and the role of the grain boundaries in the macroscopic response.
Rates of disease progression by baseline CD4 cell count and viral load after initiating triple-drug therapy.

CONTEXT Current recommendations for initiation of antiretroviral therapy in patients infected with human immunodeficiency virus type 1 (HIV) are based on CD4 T-lymphocyte cell counts and plasma HIV RNA levels. The relative prognostic value of each marker following initiation of therapy has not been fully characterized. OBJECTIVE To describe rates of disease progression to death and AIDS or death among patients starting triple-drug antiretroviral therapy, stratified by baseline CD4 cell count and HIV RNA levels. DESIGN, SETTING, AND PARTICIPANTS Population-based analysis of 1219 antiretroviral therapy-naive HIV-positive men and women aged 18 years or older in British Columbia who initiated triple-drug therapy between August 1, 1996, and September 30, 1999. MAIN OUTCOME MEASURE Cumulative mortality rates from the initiation of triple-drug antiretroviral therapy to September 30, 2000, determined using various CD4 cell and plasma HIV RNA thresholds. RESULTS As of September 30, 2000, 82 patients had died of AIDS-related causes, for a crude AIDS-related mortality rate of 6.7%. The product limit estimate (SE) of the cumulative mortality rate at 12 months was 2.9% (0.5%). In univariate analyses, a prior diagnosis of acquired immunodeficiency syndrome (AIDS), CD4 cell count, use of protease inhibitors, and HIV RNA level were associated with mortality. There was no difference in mortality by age or sex. Only CD4 cell count remained statistically significant in the multivariate analysis. After controlling for AIDS, protease inhibitor use, and plasma HIV RNA level at baseline, patients with CD4 cell counts of less than 50/microL were 6.67 (95% confidence interval [CI], 3.61-12.34) times and those with counts of 50/microL to 199/microL were 3.41 (95% CI, 1.93-6.03) times more likely to die than those with counts of at least 200/microL. CONCLUSION Our data demonstrate uniformly low rates of disease progression to death and AIDS or death among patients starting antiretroviral therapy with CD4 cell counts of at least 200/microL. In our study, disease progression to death and AIDS or death was clustered among patients starting therapy with CD4 cell counts less than 200/microL.
Parameter estimation for fractional transport: A particle‐tracking approach

Space‐fractional advection‐dispersion models provide attractive alternatives to the classical advection‐dispersion equation for model applications that exhibit early arrivals and plume skewness. This paper develops a flexible method for estimating the parameters of the fractional transport model on the basis of spatial plume snapshots or temporal breakthrough curve data. A particle‐tracking approach provides error bars for the parameter estimates and a general method for model fitting and comparison via optimal weighted least squares. A simple model of concentration variance, based on the particle‐tracking approach, identifies the optimal weights.
Stochastic Generation of Gamma-Band Activity in Primary Visual Cortex of Awake and Anesthetized Monkeys

Oscillatory neural activity within the gamma band (25–90 Hz) is generally thought to be able to provide a timing signal for harmonizing neural computations across different brain regions. Using time–frequency analyses of the dynamics of gamma-band activity in the local field potentials recorded from monkey primary visual cortex, we found identical temporal characteristics of gamma activity in both awake and anesthetized brain states, including large variability of peak frequency, brief oscillatory epochs (<100 ms on average), and stochastic statistics of the incidence and duration of oscillatory events. These findings indicate that gamma-band activity is temporally unstructured and is inherently a stochastic signal generated by neural networks. This idea was corroborated further by our neural-network simulations. Our results suggest that gamma-band activity is too random to serve as a clock signal for synchronizing neuronal responses in awake as in anesthetized monkeys. Instead, gamma-band activity is more likely to be filtered neuronal network noise. Its mean frequency changes with global state and is reduced under anesthesia.
Ovarian cyst formation in patients using tamoxifen for breast cancer.

OBJECTIVE The purpose of this study was to evaluate patient-related parameters that determine ovarian cyst formation in women using tamoxifen for breast cancer. METHODS A retrospective review of tamoxifen-treated women with breast cancer who were followed up in the outpatient clinic at Ankara Oncology Hospital between January 2002 and December 2004 was performed. Tamoxifen doses and duration, post-treatment menstrual function, adjuvant therapy, ultrasonographic and hormonal [follicle-stimulating hormone and serum estradiol (E(2))] data, details of gynecologic surgical procedure and histopathology were recorded. RESULTS Twenty-nine of 150 tamoxifen-treated patients (19.3%) had ovarian cysts. Cysts were detected in 28 of 57 pre-menopausal women (49.1%) and 1 of 93 post-menopausal women (1.1%). Patients with ovarian cysts had higher serum E(2) levels compared with patients without cysts (24 versus 345 pg/ml; P < 0.001). Patients with ovarian cysts had <1 year amenorrhoea duration (P < 0.001) compared with the patients without cysts. Adjuvant standard chemotherapy did not have relationship between the development of ovarian cysts. Multivariant analysis showed that cyst development is related to high E(2) levels (P < 0.05). CONCLUSIONS Patients still having a menstrual cycle during tamoxifen had high risk (58.33%) of developing ovarian cysts. We have described an association between pre-menopausal patients using tamoxifen with high E(2) level and ovarian cyst enlargement.
Explicit and implicit issues in the developmental cognitive neuroscience of social inequality

The appearance of developmental cognitive neuroscience (DCN) in the socioeconomic status (SES) research arena is hugely transformative, but challenging. We review challenges rooted in the implicit and explicit assumptions informing this newborn field. We provide balanced theoretical alternatives on how hypothesized psychological processes map onto the brain (e.g., problem of localization) and how experimental phenomena at multiple levels of analysis (e.g., behavior, cognition and the brain) could be related. We therefore examine unclear issues regarding the existing perspectives on poverty and their relationships with low SES, the evidence of low-SES adaptive functioning, historical precedents of the “alternate pathways” (neuroplasticity) interpretation of learning disabilities related to low-SES and the notion of deficit, issues of “normativity” and validity in findings of neurocognitive differences between children from different SES, and finally alternative interpretations of the complex relationship between IQ and SES. Particularly, we examine the extent to which the available laboratory results may be interpreted as showing that cognitive performance in low-SES children reflects cognitive and behavioral deficits as a result of growing up in specific environmental or cultural contexts, and how the experimental findings should be interpreted for the design of different types of interventions—particularly those related to educational practices—or translated to the public—especially the media. Although a cautionary tone permeates many studies, still, a potential deficit attribution—i.e., low-SES is associated with cognitive and behavioral developmental deficits—seems almost an inevitable implicit issue with ethical implications. Finally, we sketch the agenda for an ecological DCN, suggesting recommendations to advance the field, specifically, to minimize equivocal divulgation and maximize ethically responsible translation.
Automated updating of simplified component models for exhaust system dynamics simulations

To facilitate overall lay-out optimisation simplified component models for dynamics simulations of automobile exhaust systems are desired. Such optimisation could otherwise be computationally expensive, especially when non-linear analyses are necessary. Suggestions of simplified models of the mufflers and the catalyst are given. To account for the flexibility at the connections between those components and the pipes short beam elements with individual properties are introduced at these locations. An automated updating procedure is developed to determine the properties of these beam elements. Results from an experimental modal analysis are used as the reference. The theoretical model of the exhaust system is built in the finite element software ABAQUS. The updating procedure uses the sequential quadratic programming algorithm included in the Optimization Toolbox of the software MATLAB to minimise the sum of the differences between experimentally and theoretically obtained natural frequencies. Constraints are used on the correlation between the experimentally and theoretically obtained mode shapes by considering the MAC-matrix. Communication between the two software packages is established by an in-house MATLAB script. The correlation between results from the updated theoretical model and the experimental results is very good, which indicates that the updating procedure works well.
Multi-Document Abstractive Summarization Using ILP Based Multi-Sentence Compression

Abstractive summarization is an ideal form of summarization since it can synthesize information from multiple documents to create concise informative summaries. In this work, we aim at developing an abstractive summarizer. First, our proposed approach identifies the most important document in the multi-document set. The sentences in the most important document are aligned to sentences in other documents to generate clusters of similar sentences. Second, we generate K-shortest paths from the sentences in each cluster using a word-graph structure. Finally, we select sentences from the set of shortest paths generated from all the clusters employing a novel integer linear programming (ILP) model with the objective of maximizing information content and readability of the final summary. Our ILP model represents the shortest paths as binary variables and considers the length of the path, information score and linguistic quality score in the objective function. Experimental results on the DUC 2004 and 2005 multi-document summarization datasets show that our proposed approach outperforms all the baselines and state-of-the-art extractive summarizers as measured by the ROUGE scores. Our method also outperforms a recent abstractive summarization technique. In manual evaluation, our approach also achieves promising results on informativeness and readability.
A Study of the Soft Skills that Contribute to the Success of Newly Graduated Business Students in the Workplace

This quantitative study is focused on assessing the soft skills that newly graduated business students possess. Using the first and only skills inventory in the United States that has been endorsed by Department of Labor, the study seeks to determine what sets employees apart based on their level of performance on the job. The main purpose was to assess and interpret the soft skills that employees bring to the workplace soon after graduating. The population for the current study was human resources professionals from a variety of industry sectors in the state of Minnesota. The businesses represented a range of sizes from small and medium businesses to large, global corporations. Results of the survey could benefit not just the businesses that hire graduates but also those in higher education and current and future students. Copyright 2018 by Promeet Jaswant Singh
The power of negative thinking: Paradoxical but effective ignoring of salient-but-irrelevant stimuli with a spatial cue

ABSTRACT A uniquely coloured singleton among other uniformly coloured stimuli can function as a powerful attractor of attention. However, top-down attentional mechanisms are also powerful, and there are circumstances in which they can suppress irrelevant distractors. The current study tested whether an endogenous spatial cue indicating the location of a salient colour singleton distractor can eliminate involuntary attentional allocation to such a stimulus. When an arrow cue indicated a to-be-ignored location that would never contain a target but would contain a colour singleton distractor, a significant singleton capture effect was eliminated on ignore trials regardless of the consistency of the singleton colour in Experiments 1 and 2. In Experiment 3, a consistent colour singleton was used without a spatial cue. Participants were not able to suppress singleton distractors in the absence of a cue. However, in Experiments 1 & 2, the status of a letter inscribed in the singleton (i.e., whether it is compatible or incompatible with the target of the search) did affect reaction time on ignore trials. If the compatibility effect indicates a shift of attention to the singleton, the data may mean that, with a spatial cue, participants inhibit a cued location by first selecting the location and then rapidly disengaging from it.
Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma

Bcl2 and IAP families are anti-apoptotic proteins deregulated in multiple myeloma (MM) cells. Pharmacological inhibition of each of these families has shown significant activity only in subgroups of MM patients. Here, we have examined a broad-spectrum Bcl2 family inhibitor Obatoclax (OBX) in combination with a Smac mimetic LCL161 in MM cell lines and patient cells. LCL161/OBX combination induced synergistic cytotoxicity and anti-proliferative effects on a broad range of human MM cell lines. The cytotoxicity was mediated through inhibition of the IAPs, activation of caspases and up regulation of the pro-apoptotic proteins Bid, Bim, Puma and Noxa by the drug combination. In addition, we observed that OBX caused ER stress and activated the Unfolded Protein Response (UPR) leading to drug resistance. LCL161, however inhibited spliced Xbp-1, a pro-survival factor. In addition, we observed that OBX increased GRP78 localization to the cell surface, which then induced PI3K dependent Akt activation and resistance to cell death. LCL161 was able to block OBX induced Akt activation contributing to synergistic cell death. Our results support clinical evaluation of this combination strategy in relapsed refractory MM patients.