Miracle-dz/UniFAR-FTUs huggingface dataset:
Suspecting and spotting paediatric sepsis

The febrile child is one of the most common presentations to the paediatric ED, accounting for 20% of visits. Most cases are benign, selflimiting viral infections. A small proportion will have a serious bacterial infection (SBI) or evolving sepsis. The consequences of failing to recognise and treat paediatric sepsis in a timely manner are devastating and often fatal. For emergency physicians, missing paediatric sepsis is a commonly held fear. There are often minimal clinical signs to herald a serious infection, while bedside tests are not without limitations. In the post-vaccination era, the prevalence of occult bacteraemia and consequent sepsis in the developed world is remarkably low, with reported rates <1%. In our lowprevalence setting, paediatric sepsis therefore represents a relatively rare syndrome with non-specific clinical signs, no perfect diagnostic test but fatal consequences if missed.
Systematic review of raloxifene in postmenopausal Japanese women with osteoporosis or low bone mass (osteopenia)

Purpose To systematically review the literature describing the efficacy, effectiveness, and safety of raloxifene for postmenopausal Japanese women with osteoporosis or low bone mass (osteopenia). Materials and methods Medline via PubMed and Embase was systematically searched using prespecified terms. Retrieved publications were screened and included if they described randomized controlled trials or observational studies of postmenopausal Japanese women with osteoporosis or osteopenia treated with raloxifene and reported one or more outcome measures (change in bone mineral density [BMD]; fracture incidence; change in bone-turnover markers, hip structural geometry, or blood–lipid profile; occurrence of adverse events; and change in quality of life or pain). Excluded publications were case studies, editorials, letters to the editor, narrative reviews, or publications from non-peer-reviewed journals; multidrug, multicountry, or multidisease studies with no drug-, country-, or disease-level analysis; or studies of participants on dialysis. Results Of the 292 publications retrieved, 15 publications (seven randomized controlled trials, eight observational studies) were included for review. Overall findings were statistically significant increases in BMD of the lumbar spine (nine publications), but not the hip region (eight publications), a low incidence of vertebral fracture (three publications), decreases in markers of bone turnover (eleven publications), improved hip structural geometry (two publications), improved blood–lipid profiles (five publications), a low incidence of hot flushes, leg cramps, venous thromboembolism, and stroke (12 publications), and improved quality of life and pain relief (one publication). Conclusion Findings support raloxifene for reducing vertebral fracture risk by improving BMD and reducing bone turnover in postmenopausal Japanese women with osteoporosis or osteopenia. Careful consideration of fracture risk and the risk–benefit profile of antiosteoporosis medications is required when managing patients with osteoporosis.
Impact of Green Manure and Consortium Biofertilizer on Amylolytic Bacterial Population and Their Activities in Maize Rhizospheric Soil

Microbial population and their activities in soil are important measure of soil biological activities as well as its health. The present study was conducted to access the impact of application of green manure and cellulose degrading bacterial consortium on the soil amylolytic bacterial population and amylase activity in rhizosphere of maize crop in field conditions. Soil amylolytic bacteria and amylase activity exhibited significant changes in response to application of consortium biofertilizer. The highest population of amylolytic bacteria was recorded during vegetative stage of maize crop in treatment T8 with 100%N + green manure+ consortium biofertilizer. Amylolytic population was found to be significantly higher in treatments having inorganic N + consortium biofertilizers as compared to control treatment. Soil amylase activity was significantly influenced by organic manure and vegetative growth stage. Highest amylase activity was recorded in treatment T8, whereas minimum activity was recorded in control (inorganic) treatment. Application of consortium biofertilizers significantly increased the amylase activity over treatments having solitary application of inorganic fertilizers. The results suggested that application of consortium biofertilizers on green manure boosted the colonisation and activities of amylolytic bacteria which directly influenced the available carbon pool as well as soil health.
Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation

The role that potassium channels play in human T lymphocyte activation has been investigated by using specific potassium channel probes. Charybdotoxin (ChTX), a blocker of small conductance Ca(2+)-activated potassium channels (PK,Ca) and voltage-gated potassium channels (PK,V) that are present in human T cells, inhibits the activation of these cells. ChTX blocks T cell activation induced by signals (e.g., anti- CD2, anti-CD3, ionomycin) that elicit a rise in intracellular calcium ([Ca2+]i) by preventing the elevation of [Ca2+]i in a dose-dependent manner. However, ChTX has no effect on the activation pathways (e.g., anti-CD28, interleukin 2 [IL-2]) that are independent of a rise in [Ca2+]i. In the former case, both proliferative response and lymphokine production (IL-2 and interferon gamma) are inhibited by ChTX. The inhibitory effect of ChTX can be demonstrated when added simultaneously, or up to 4 h after the addition of the stimulants. Since ChTX inhibits both PK,Ca and PK,V, we investigated which channel is responsible for these immunosuppressive effects with the use of two other peptides, noxiustoxin (NxTX) and margatoxin (MgTX), which are specific for PK,V. These studies demonstrate that, similar to ChTX, both NxTX and MgTX inhibit lymphokine production and the rise in [Ca2+]i. Taken together, these data provide evidence that blockade of PK,V affects the Ca(2+)-dependent pathways involved in T lymphocyte proliferation and lymphokine production by diminishing the rise in [Ca2+]i that occurs upon T cell activation.
Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats

The S-phase checkpoint plays an essential role in regulation of the ribonucleotide reductase (RNR) activity to maintain the dNTP pools. How eukaryotic cells respond appropriately to different levels of replication threats remains elusive. Here, we have identified that a conserved GSK-3 kinase Mck1 cooperates with Dun1 in regulating this process. Deleting MCK1 sensitizes dun1Δ to hydroxyurea (HU) reminiscent of mec1Δ or rad53Δ. As a kinase at the downstream of Rad53, Mck1 does not participate in the post-translational regulation of RNR as Dun1 does, but Mck1 can release the Crt1 repressor from the promoters of RNR2/3/4 by phosphorylation. Meanwhile, Hug1, an Rnr2 inhibitor, is induced to fine-tune the dNTP levels. When cells suffer a more severe threat, Mck1 can inhibit the transcription of HUG1. Importantly, only a combined deletion of HUG1 and CRT1, can confer a dramatic boost of dNTP levels and the survival of mck1Δdun1Δ or mec1Δ cells assaulted by a lethal dose of HU. These findings reveal the division-of-labor between Mck1 and Dun1 at the S-phase checkpoint pathway to fine-tune dNTP homeostasis. Author Summary The appropriate amount and balance of four dNTPs are crucial for all cells correctly copying and passing on their genetic material generation by generation. Eukaryotes have developed an alert and response system to deal with the disturbance. Here, we uncovered a second-level effector branch. It is activated by the upstream surveillance kinase cascade, which can induce the expression of dNTP-producing enzymes. It can also reduce the inhibitor of these enzymes to further boost their activity according to the degrees of threats. These findings suggest a multi-level response system to guarantee dNTP supply, which is essential to maintain genetic stability under various environmental challenges.
Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial.

CONTEXT Depression is common in patients with cardiac disease, especially in patients with heart failure, and is associated with increased risk of adverse health outcomes. Some evidence suggests that aerobic exercise may reduce depressive symptoms, but to our knowledge the effects of exercise on depression in patients with heart failure have not been evaluated. OBJECTIVE To determine whether exercise training will result in greater improvements in depressive symptoms compared with usual care among patients with heart failure. DESIGN, SETTING, AND PARTICIPANTS Multicenter, randomized controlled trial involving 2322 stable patients treated for heart failure at 82 medical clinical centers in the United States, Canada, and France. Patients who had a left ventricular ejection fraction of 35% or lower, had New York Heart Association class I to IV heart failure, and had completed the Beck Depression Inventory II (BDI-II) score were randomized (1:1) between April 2003 and February 2007. Depressive scores ranged from 0 to 59; scores of 14 or higher are considered clinically significant. INTERVENTIONS Participants were randomized either to supervised aerobic exercise (goal of 90 min/wk for months 1-3 followed by home exercise with a goal of ≥120 min/wk for months 4-12) or to education and usual guideline-based heart failure care. MAIN OUTCOME MEASURES Composite of death or hospitalization due to any cause and scores on the BDI-II at months 3 and 12. RESULTS Over a median follow-up period of 30 months, 789 patients (68%) died or were hospitalized in the usual care group compared with 759 (66%) in the aerobic exercise group (hazard ratio [HR], 0.89; 95% CI, 0.81 to 0.99; P = .03). The median BDI-II score at study entry was 8, with 28% of the sample having BDI-II scores of 14 or higher. Compared with usual care, aerobic exercise resulted in lower mean BDI-II scores at 3 months (aerobic exercise, 8.95; 95% CI, 8.61 to 9.29 vs usual care, 9.70; 95% CI, 9.34 to 10.06; difference, -0.76; 95% CI,-1.22 to -0.29; P = .002) and at 12 months (aerobic exercise, 8.86; 95% CI, 8.67 to 9.24 vs usual care, 9.54; 95% CI, 9.15 to 9.92; difference, -0.68; 95% CI, -1.20 to -0.16; P = .01). CONCLUSIONS Compared with guideline-based usual care, exercise training resulted in a modest reduction in depressive symptoms, although the clinical significance of this improvement is unknown. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00047437.
Recollection and Familiarity in Recognition Memory: An Event-Related Functional Magnetic Resonance Imaging Study

The question of whether recognition memory judgments with and without recollection reflect dissociable patterns of brain activity is unresolved. We used event-related, functional magnetic resonance imaging (fMRI) of 12 healthy volunteers to measure hemodynamic responses associated with both studying and recognizing words. Volunteers made one of three judgments to each word during recognition: whether they recollected seeing it during study (R judgments), whether they experienced a feeling of familiarity in the absence of recollection (K judgments), or whether they did not remember seeing it during study (N judgments). Both R and K judgments for studied words were associated with enhanced responses in left prefrontal and left parietal cortices relative to N judgments for unstudied words. The opposite pattern was observed in bilateral temporoccipital regions and amygdalae. R judgments for studied words were associated with enhanced responses in anterior left prefrontal, left parietal, and posterior cingulate regions relative to K judgments. At study, a posterior left prefrontal region exhibited an enhanced response to words subsequently given R versus K judgments, but the response of this region during recognition did not differentiate R and K judgments. K judgments for studied words were associated with enhanced responses in right lateral and medial prefrontal cortex relative to both R judgments for studied words and N judgments for unstudied words, a difference we attribute to greater monitoring demands when memory judgments are less certain. These results suggest that the responses of different brain regions do dissociate according to the phenomenology associated with memory retrieval.
Risks and benefits of speech recognition for clinical documentation: a systematic review

OBJECTIVE To review literature assessing the impact of speech recognition (SR) on clinical documentation. METHODS Studies published prior to December 2014 reporting clinical documentation using SR were identified by searching Scopus, Compendex and Inspect, PubMed, and Google Scholar. Outcome variables analyzed included dictation and editing time, document turnaround time (TAT), SR accuracy, error rates per document, and economic benefit. Twenty-three articles met inclusion criteria from a pool of 441. RESULTS Most studies compared SR to dictation and transcription (DT) in radiology, and heterogeneity across studies was high. Document editing time increased using SR compared to DT in four of six studies (+1876.47% to -16.50%). Dictation time similarly increased in three of five studies (+91.60% to -25.00%). TAT consistently improved using SR compared to DT (16.41% to 82.34%); across all studies the improvement was 0.90% per year. SR accuracy was reported in ten studies (88.90% to 96.00%) and appears to improve 0.03% per year as the technology matured. Mean number of errors per report increased using SR (0.05 to 6.66) compared to DT (0.02 to 0.40). Economic benefits were poorly reported. CONCLUSIONS SR is steadily maturing and offers some advantages for clinical documentation. However, evidence supporting the use of SR is weak, and further investigation is required to assess the impact of SR on documentation error types, rates, and clinical outcomes.
Playing with Nintendo Wii Sports: Impact on Physical Activity, Perceived Health and Cognitive Functioning of a Group of Community-Dwelling Older Adults

ABSTRACT This study aims to analyze whether participation in a programme using exergames improves the amount of physical activity performance, perceived health and cognitive functioning. The sample was composed of 38 community-dwelling older adults. The intervention group (n = 22) participated in 12 1-hour sessions using the Nintendo Wii Sports. Statistically, significant differences can be observed between intervention and control groups regarding some cognitive variables such as executive functioning and divided attention. The results suggest the need to further study the role of exergames on the health of older adults as a potential work tool to promote physical, and psychological well-being.
Individual characteristics influencing the sharing of knowledge on social networking services: online identity, self-efficacy, and knowledge sharing intentions

ABSTRACT Social media have become an important place for individuals with similar interests to exchange opinions and share resources. Ubiquitous collaborative learning environments in SNS have great educational and organisational potential and offer a platform for sharing knowledge. Rising interest in personal factors in knowledge management research calls for a better understanding of how knowledge is shared in SNS-based collaborative learning. Grounded on the theories of planned behaviour and social identity, this study investigates individual characteristics that affect the sharing of knowledge in SNS learning communities. The study also examines whether intent to share knowledge mediates those personal characteristics and sharing of knowledge. Eighty individuals from five active Facebook groups participated in this study. The findings indicate that individual characteristics, such as online personal identity, web-specific self-efficacy, and knowledge-creation self-efficacy significantly predict sharing of knowledge. In addition, intent to share knowledge mediates between the sharing of knowledge and online identity, web-specific self-efficacy, or knowledge-creation self-efficacy. The results reveal a need for customised support and environmental design focusing on online personal identity, web-specific self-efficacy, knowledge-creation self-efficacy, and intent to share knowledge in a knowledge-sharing community on SNS. Implications for the SNS communities and suggestions for further research are discussed.
Are Multiple Reference Translations Necessary? Investigating the Value of Paraphrased Reference Translations in Parameter Optimization

Most state-of-the-art statistical machine translation systems use log-linear models, which are defined in terms of hypothesis features and weights for those features. It is standard to tune the feature weights in order to maximize a translation quality metric, using held-out test sentences and their corresponding reference translations. However, obtaining reference translations is expensive. In our earlier work (Madnani et al., 2007), we introduced a new full-sentence paraphrase technique, based on English-to-English decoding with an MT system, and demonstrated that the resulting paraphrases can be used to cut the number of human reference translations needed in half. In this paper, we take the idea a step further, asking how far it is possible to get with just a single good reference translation for each item in the development set. Our analysis suggests that it is necessary to invest in four or more human translations in order to significantly improve on a single translation augmented by monolingual paraphrases.
Group IIA Secretory Phospholipase A2, Vascular Inflammation, and Incident Cardiovascular Disease.

Objective- Inflammation is a causal risk factor for cardiovascular disease (CVD). sPLA2-IIA (group IIA secretory phospholipase A2) plays an integral role in regulating vascular inflammation. Although studies investigated sPLA2-IIA in secondary prevention, we prospectively evaluated sPLA2-IIA mass and genetic variants with CVD events in a primary prevention population with chronic inflammation. Approach and Results- The JUPITER trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin) randomized participants with LDL (low-density lipoprotein) <130 mg/dL and hsCRP (high-sensitivity C-reactive protein) ≥2 mg/L to high-intensity rosuvastatin versus placebo. Baseline and 1-year plasma sPLA2-IIA mass was measured (N=11 269 baseline; N=9620 1 year). We also identified genetic variants influencing sPLA2-IIA using genome-wide association and examined them with CVD. Three hundred thirteen incident CVD events occurred during follow-up. Baseline sPLA2-IIA mass (median, 25th-75th percentile: 3.81, 2.49-6.03 ng/mL) was associated with increased risk of CVD: risk factor-adjusted hazard ratio (95% CI; P) per SD increment: 1.22 (1.08-1.38; P=0.002). This remained significant (1.18; 1.04-1.35; P=0.01) after incrementally adjusting for hsCRP. Similar estimates were observed in rosuvastatin and placebo groups ( P treatment interaction>0.05). The rs11573156C variant in PLA2G2A (encoding sPLA2-IIA) had the strongest effect on sPLA2-II: median (25th-75th percentile, ng/mL) for CC and GG genotypes: 2.79 (1.97-4.01) and 7.38 (5.38-10.19), respectively; and had nonsignificant trend for higher CVD risk (hazard ratio, 1.11; 95% CI, 0.89-1.38; P=0.34). Conclusions- In the JUPITER population recruited on chronic inflammation, sPLA2-IIA mass was associated with CVD risk relating to vascular inflammation not fully reflected by hsCRP. Additional studies, including larger functional genetic and clinical studies, are needed to determine whether sPLA2-IIA may be a potential pharmacological target for primary prevention of CVD. Clinical Trial Registration- URL: http://www.clinicaltrials. gov . Unique identifier: NCT00239681.
Mitotane levels predict the outcome of patients with adrenocortical carcinoma treated adjuvantly following radical resection.

CONTEXT Mitotane plasma concentrations ≥ 14 mg/l have been shown to predict tumor response and better survival in patients with advanced adrenocortical carcinoma (ACC). A correlation between mitotane concentrations and patient outcome has not been demonstrated in an adjuvant setting. OBJECTIVE To compare recurrence-free survival (RFS) in patients who reached and maintained mitotane concentrations ≥ 1 4 mg/l vs patients who did not. DESIGN AND SETTING Retrospective analysis at six referral European centers. PATIENTS Patients with ACC who were radically resected between 1995 and 2009 and were treated adjuvantly with mitotane targeting concentrations of 14-20 mg/l. MAIN OUTCOME MEASURES RFS (primary) and overall survival (secondary). RESULTS Of the 122 patients included, 63 patients (52%) reached and maintained during a median follow-up of 36 months the target mitotane concentrations (group 1) and 59 patients (48%) did not (group 2). ACC recurrence was observed in 22 patients of group 1 (35%) and 36 patients in group 2 (61%). In multivariable analysis, the maintenance of target mitotane concentrations was associated with a significantly prolonged RFS (hazard ratio (HR) of recurrence: 0.418, 0.22-0.79; P=0.007), while the risk of death was not significantly altered (HR: 0.59, 0.26-1.34; P=0.20). Grades 3-4 toxicity was observed in 11 patients (9%) and was managed with temporary mitotane discontinuation. None of the patients discontinued mitotane definitively for toxicity. CONCLUSIONS Mitotane concentrations ≥ 14 mg/l predict response to adjuvant treatment being associated with a prolonged RFS. A monitored adjuvant mitotane treatment may benefit patients after radical removal of ACC.
QoS framework for Mobile-to-Mobile multimedia streaming applications

Provisioning high profile multimedia applications over the bandwidth-constrained cellular networks is not simply straight forward. Quality of Service (QoS) has always been a debatable issue in this regard. Network over-provisioning can be a solution but not an economical one. Therefore, the operators have to employ more sophisticated control and policy enforcement mechanism in order to ensure the quality of individual services running over their network. More precisely, they require an efficient way to perform service differentiation and applying QoS policies accordingly. The paper proposes a QoS framework for an existing Mobile Server Platform (MSP), which is envisaged as the foundation of M2M (Mobile-to-Mobile) service networks over the operator IMS (IP Multimedia Subsystem) network. The paper enfolds that how the proposed QoS framework operates in the user registration, session establishment and multimedia delivery phase of an ongoing multimedia session. A promising feature of the proposed framework is to allow the cellular operators to employ QoS control based on the user profiles classification. Hence, a systematic approach is adopted to study the behaviour of a video streaming prototype based on different network settings and various user profiles.