Miracle-dz/UniFAR-FTUs huggingface dataset:
Diversification of Photoperiodic Response Patterns in a Collection of Early-Flowering Mutants of Arabidopsis1[W]

Many plant species exhibit seasonal variation of flowering time in response to daylength. Arabidopsis (Arabidopsis thaliana) flowers earlier under long days (LDs) than under short days (SDs). This quantitative response to photoperiod is characterized by two parameters, the critical photoperiod (Pc), below which there is a delay in flowering, and the ceiling photoperiod (Pce), below which there is no further delay. Thus Pc and Pce define the thresholds beyond which maximum LD and SD responses are observed, respectively. We studied the quantitative response to photoperiod in 49 mutants selected for early flowering in SDs. Nine of these mutants exhibited normal Pce and Pc, showing that their precocious phenotype was not linked to abnormal measurement of daylength. However, we observed broad diversification in the patterns of quantitative responses in the other mutants. To identify factors involved in abnormal measurement of daylength, we analyzed the association of these various patterns with morphogenetic and rhythmic defects. A high proportion of mutants with altered Pce exhibited abnormal hypocotyl elongation in the dark and altered circadian periods of leaf movements. This suggested that the circadian clock and negative regulators of photomorphogenesis may contribute to the specification of SD responses. In contrast, altered Pc correlated with abnormal hypocotyl elongation in the light and reduced photosynthetic light-input requirements for bolting. This indicated that LD responses may be specified by positive elements of light signal transduction pathways and by regulators of resource allocation. Furthermore, the frequency of circadian defects in mutants with normal photoperiodic responses suggested that the circadian clock may regulate the number of leaves independently of its effect on daylength perception.
Potential Markers for Detection and Monitoring of Ovarian Cancer

This paper reviews current screening techniques as well as novel biomarkers and their potential role in early detection of ovarian cancer. Ovarian cancer is one of the most common reproductive cancers and has the highest mortality rate amongst gynecologic cancers. Because most ovarian cancer diagnoses occur in the late stages of the disease, five-year survival rates fall below 20%. To improve survival rates and to lower mortality rates for ovarian cancer, improved detection at early stages of the disease is needed. Current screening approaches include tumor markers, ultrasound, or a combination. Efforts are underway to discover new biomarkers of ovarian cancer in order to surmount the obstacles in early-stage diagnosis. Among serum protein markers, HE4 and mesothelin can augment CA125 detection providing higher sensitivity and specificity due to the presence of these proteins in early-stage ovarian cancer. Detection testing that includes methylation of the MCJ gene and increased expression of vascular endothelial growth factor is correlated to poor prognosis and may predict patient survival outcome. Detection testing of biomarkers with long-term stability and combination panels of markers, will likely lead to effective screening strategies with high specificity and sensitivity for early detection of ovarian cancer.
Improved estimation method of soil wind erosion based on remote sensing and geographic information system in the Xinjiang Uygur Autonomous Region, China

ABSTRACT Detailed information pertaining to soil erosion is required to ensure eco-environment protection and economic development for Xinjiang Uygur Autonomous Region, and remote sensing and geographical information system technologies are adopted to obtain an accurate distribution of soil erosion. An improved estimation method for wind erosion is developed, which proves to be effective with an overall precision of 87.24%. The proposed model uses six critical factors: number of snow cover days, soil erodibility, aridity index, vegetation fraction, soil crust index, and wind field intensity. Results show that soil wind erosion is widely distributed throughout the Xinjiang Uygur Autonomous Region. The average erosion intensity is 0.50, which is determined to be a moderate erosion level. The wind erosion intensity increases from a slight level in the western part to a severe level in the mid-eastern part. The mean intensity of soil wind erosion for varying land use types is ranked in descending magnitude of barren or sparse vegetation, open shrubland, grassland, cropland, evergreen coniferous forest, and mixed forest. There are large differences in soil wind erosion intensities among soil types; grassland has severe wind erosion and Luvic Arenosols has the lowest erosion intensity.
OFDM-based overlay cognitive radios with improved spectral leakage suppression for future generation communications

Dynamic spectrum sharing with minimum spectrum leakage is actively considered to meet the requirements of future generation networks which are expected to support huge amount of data traffic beyond 2020 with limited spectrum. In this paper, we propose a spectral leakage suppression technique for orthogonal frequency division multiplexing (OFDM)-based overlay cognitive radio (CR). We apply the Bohman window-based pulse shaping, which has a high sidelobe fall rate and low highest sidelobe power, to the edge subcarriers rather than the entire waveform of the secondary users (SUs) utilized spectrum. We allocate antipodal symbol pairs to the Bohman-windowed subcarriers to overcome the problem of a slightly large 3-dB bandwidth of the Bohman window. The power spectral density (PSD) of the proposed scheme rolls off asymptotically as of f-8, as compared to the current state-of-the-art where the sidelobe rolls off asymptotically as of f-4. Simulation results show improved bit-error-rate (BER) performances of the primary user (PU) and the SU in the proposed scheme due to improved spectral leakage suppression. The practicality of the proposed scheme is validated by field programmable gate array (FPGA) prototyping.
Circulating Levels of Hormones, Lipids, and Immune Mediators in Post-Traumatic Stress Disorder – A 3-Month Follow-Up Study

A number of peripheral blood analytes have been proposed as potential biomarkers of post-traumatic stress disorder (PTSD). Few studies have investigated whether observed changes in biomarkers persist over time. The aim of this study was to investigate the association of combat-related chronic PTSD with a wide array of putative PTSD biomarkers and to determine reliability of the measurements, i.e., correlations over time. Croatian combat veterans with chronic PTSD (n = 69) and age-matched healthy controls (n = 32), all men, were assessed at two time points separated by 3 months. Serum levels of lipids, cortisol, dehydroepiandrosterone-sulfate (DHEA-S), prolactin, and C-reactive protein were determined. Multiplex assay was used for the simultaneous assessment of 13 analytes in sera: cytokines [interferon-γ, interleukin (IL)-1β, IL-2, IL-4, IL-6, TNF-α], adhesion molecules (sPECAM-1, sICAM-1), chemokines (IL-8 and MIP-1α), sCD40L, nerve growth factor, and leptin. Group differences and changes over time were tested by parametric or non-parametric tests, including repeated measures analysis of covariance. Reliability estimates [intraclass correlation coefficient (ICC) and kappa] were also calculated. Robust associations of PTSD with higher levels of DHEA-S [F(1,75) = 8.14, p = 0.006)] and lower levels of prolactin [F(1,75) = 5.40, p = 0.023] were found. Measurements showed good to excellent reproducibility (DHEA-S, ICC = 0.50; prolactin, ICC = 0.79). Serum lipids did not differ between groups but significant increase of LDL-C after 3 months was observed in the PTSD group (t = 6.87, p < 0.001). IL-8 was lower in the PTSD group (t = 4.37, p < 0.001) but assessments showed poor reproducibility (ICC = −0.08). Stable DHEA-S and prolactin changes highlight their potential to be reliable markers of PTSD. Change in lipid profiles after 3 months suggests that PTSD patients may be more prone to hyperlipidemia. High intra-individual variability in some variables emphasizes the importance of longitudinal studies in investigations of PTSD biomarkers.
Biological Assessment of Aspirin Efficacy on Healthy Individuals: Heterogeneous Response or Aspirin Failure?

Background and Purpose— The widespread use of aspirin requires clarification of the aspirin resistance phenomenon. Most studies on this field are focused on patients which may affect the action of aspirin. Methods— We evaluated the biological efficacy of aspirin in healthy subjects. Results— Agonist–induced platelet aggregation was fully abrogated by 100 mg of aspirin in all individuals. By contrast, with the platelet function analyzer-100 device, 33.3% of the subjects displayed no response. This failure was overcome by 500 mg or by in vitro treatment of blood with 30 &mgr;mol/L acetylsalicylic acid. Intake of 100 mg of aspirin efficiently reduced by 75% the level of 11-dehydro thromboxane B2 (11-dTxB2) in all cases. However, variability on the pre-aspirin level (range 72.4 to 625.9 ng/mmol creatinine) led to substantial differences in the residual amount of the metabolite between subjects treated with aspirin (range 12.9 to 118.0 ng/mmol creatinine). Finally, there was no influence of platelet glycoprotein IIb/IIIa (Pro33Leu), platelet glycoprotein Ia/IIa, (C807T), and FXIII (Val34Leu) polymorphisms on the efficacy of aspirin. However, the cyclooxygenase (Cox)-1 50T allele associated with higher level of 11-dTxB2, both before and after aspirin. Moreover, the Cox-2 −765C variant displayed a slightly higher reduction in 11-dTxB2 level on treatment with aspirin. Conclusions— Our findings suggest that full resistance of healthy subjects to aspirin is rather unlikely. However, differences in aspirin absorption, or pharmacokinetic, or other unrecognized factors may lead to lack of effect of low dose of aspirin in some subjects when using tests like platelet function analyzer-100. Whether Cox polymorphisms are thrombotic risk factor for patients under aspirin will require further research.
Robust header compression (ROHC) in next-generation network processors

Robust Header Compression (ROHC) provides for more efficient use of radio links for wireless communication in a packet switched network. Due to its potential advantages in the wireless access area and the proliferation of network processors in access infrastructure, there exists a need to understand the resource requirements and architectural implications of implementing ROHC in this environment. We present an analysis of the primary functional blocks of ROHC and extract the architectural implications on next-generation network processor design for wireless access. The discussion focuses on memory space and bandwidth dimensioning as well as processing resource budgets. We conclude with an examination of resource consumption and potential performance gains achievable by offloading computationally intensive ROHC functions to application specific hardware assists. We explore the design tradeoffs for hardware assists in the form of reconfigurable hardware, Application-Specific Instruction-set Processors (ASIPs), and Application-Specific Integrated Circuits (ASICs).
Prognostic Significance of VEGF-C Expression in Patients with Breast Cancer: A Meta-Analysis

Abstract Background Vascular endothelial growth factor (VEGF)-C, as a lymphangiogenic factor, plays important roles in the progression of several malignancies. However, its clinical prognostic value in breast cancer still remains controversial. We performed a meta-analysis of available studies to assess the association between VEGF-C expression and the ou-tcomes of breast cancer patients Methods We searched eligible studies in three English databases (MEDLINE, EMBASE, and Web of Science) and two Chinese databases (Wanfang and Chinese National Knowledge Infrastructure databases). Key words used in the research included ‘VEGF-C”, “breast cancer”, “immunohistochemistry”, “breast neoplasma(s)”, “breast carcinoma”, “metastasis”, and “prognosis”. Fourteen studies with a total of 1, 573 breast cancer cases were finally included into the meta-analysis. The pooled odds ratios (ORs) with the corresponding 95% confidence interval (95% CIs) for lymph node metastasis, overall survival, and disease-free survival were calculated by using fixed-effects or random-effects models. Heterogeneity and publication bias were also assessed. Results Meta-analysis of random-effects model showed VEGF-C expression was associated with lymph node metastasis in patients with breast cancer (random-effects, OR = 2.14; 95 % CI 1.21—3.77, P = 0.009). VEGF-C expression was associated with poorer overall survival (fixed-effects, OR = 2.46, 95% CI: 1.46—4.14, P < 0.001) and disease-free survival (fixed-effects, OR = 2.10, 95% CI: 1.32—3.35, P = 0.002) in patients with breast cancer. Conclusion VEGF-C expression is positively associated with lymph node metastasis in breast cancer, and VEGF-C detection in breast cancer might be an effective and feasible means to predict outcome.
The development of more than one histologic type of lymphoma in the same patient is frequent and confers a worse prognosis.

BACKGROUND AND OBJECTIVES Distinct types of lymphoma may develop in the same patient either simultaneously or sequentially. The frequency and clinical significance of this phenomenon are still only partially known. DESIGN AND METHODS We conducted a retrospective analysis of all cases of lymphomas of different histology occurring in the same patient, denoting these cases as multiple histology lymphoma (MHL). The clinicopathologic characteristics of these cases were compared with those of cases with a single histology (SHL). The histologic classifications were made according to the REAL classification by the same pathologists throughout the study period. RESULTS MHL were identified in 46 of 347 (13%) consecutive cases of lymphoma diagnosed at a single institution. They presented more frequently in stage III-IV (p=0.008), but the age, sex, and IPI score of patients with MHL did not differ from those of patients with SHL. Small lymphocytic/lymphoplasmacytic subtype was more frequent (16.1% vs 3%, p<0.0001) and Hodgkin's lymphoma (4% vs 16%; p=0.004) less frequent in MHL. Response rates to treatment were similar (85% vs 77.5%), whereas 5-year overall survival was significantly lower for MHL than for SHL (31% vs 67%; p=0.015). Among MHL, 14 cases were diagnosed simultaneously and 32 sequentially, after a median of 18 months. The two subgroups with simultaneous and sequential presentation did not differ in their demographic, clinicopathologic or prognostic characteristics. INTERPRETATION AND CONCLUSIONS Lymphomas of different histology develop frequently in the same patient, either simultaneously or sequentially. Patients with MHL form a subgroup with few peculiar presenting clinicopathologic features but a markedly worse prognosis, thus warranting prospective biological and clinical studies.
Chromosomal translocations induced at specified loci in human stem cells

The precise genetic manipulation of stem and precursor cells offers extraordinary potential for the analysis, prevention, and treatment of human malignancies. Chromosomal translocations are hallmarks of several tumor types where they are thought to have arisen in stem or precursor cells. Although approaches exist to study factors involved in translocation formation in mouse cells, approaches in human cells have been lacking, especially in relevant cell types. The technology of zinc finger nucleases (ZFNs) allows DNA double-strand breaks (DSBs) to be introduced into specified chromosomal loci. We harnessed this technology to induce chromosomal translocations in human cells by generating concurrent DSBs at 2 endogenous loci, the PPP1R12C/p84 gene on chromosome 19 and the IL2Rγ gene on the X chromosome. Translocation breakpoint junctions for t(19;X) were detected with nested quantitative PCR in a high throughput 96-well format using denaturation curves and DNA sequencing in a variety of human cell types, including embryonic stem (hES) cells and hES cell-derived mesenchymal precursor cells. Although readily detected, translocations were less frequent than repair of a single DSB by gene targeting or nonhomologous end-joining, neither of which leads to gross chromosomal rearrangements. While previous studies have relied on laborious genetic modification of cells and extensive growth in culture, the approach described in this report is readily applicable to primary human cells, including mutipotent and pluripotent cells, to uncover both the underlying mechanisms and phenotypic consequences of targeted translocations and other genomic rearrangements.
Biocompatibility evaluation of tissue‐engineered valved venous conduit by reseeding autologous bone marrow‐derived endothelial progenitor cells and multipotent adult progenitor cells into heterogeneous decellularized venous matrix

Clinical treatment of chronic deep venous insufficiency remains difficult despite the availability of various therapies. Previous experimental efforts have demonstrated that the tissue‐engineered valvedvenous conduit (TEVV) is a promising option to replace the damaged venous valve. The aim of the present study was to evaluate the TEVV by reseeding bone marrow‐derived endothelial progenitor cells and multipotent adult progenitor cells into acellular matrix according to International Standard ISO10993, and to clarify their interactions with blood, the local effect after implantation both in vitro and vivo, and immunogenicity. The results showed that the 2‐cm long TEVV did not cause haemolysis in vitro and remained patent without thrombosis formation in vivo. However, the luminal surface of TEVV was partially covered by multilayer cells. Compared with the native ovine femoral vein segment, the TEVV beneath the mouse skin produced significant mononuclear cell infiltration, with serum interleukin‐6 and tumour necrosis factor‐α similar to normal. The TEVV maintained its structural integrity, while the native ovine femoral vein segments fell apart at postoperative week nine. The TEVV implantation did not change serum immunoglobulin G. In addition, the seeds and extracts of the scaffold did not affect the proliferation of mouse lymphocytes. These findings suggest that the histocompatibility, haemocompatibility and immunogenicity of this TEVV are acceptable owing to complete removal of the cellular components of autologous seeds and residues of chemical regents, thus providing an experimental basis for further clinical translation. Copyright © 2014 John Wiley & Sons, Ltd.
Exploring organizational culture for information security management

Purpose – This paper aims to examine the influence of organization culture on the effectiveness of implementing information security management (ISM). Design/methodology/approach – Based on a literature review, a model of the relationship between organizational culture and ISM was formulated, and both organizational culture characteristics and ISM effectiveness were measured empirically to investigate how various organizational culture traits influenced ISM principles, by administrating questionnaires to respondents in organizations with significant use of information systems.Findings – Four regression models were derived to quantify the impacts of organizational culture traits on the effectiveness of implementing ISM. Whilst the control‐oriented organizational culture traits, effectiveness and consistency, have strong effect on the ISM principles of confidentiality, integrity, availability and accountability, the flexibility‐oriented organizational culture traits, cooperativeness and innovativeness, are n.
Conditional Generation and Snapshot Learning in Neural Dialogue Systems

Recently a variety of LSTM-based conditional language models (LM) have been applied across a range of language generation tasks. In this work we study various model architectures and different ways to represent and aggregate the source information in an end-to-end neural dialogue system framework. A method called snapshot learning is also proposed to facilitate learning from supervised sequential signals by applying a companion cross-entropy objective function to the conditioning vector. The experimental and analytical results demonstrate firstly that competition occurs between the conditioning vector and the LM, and the differing architectures provide different trade-offs between the two. Secondly, the discriminative power and transparency of the conditioning vector is key to providing both model interpretability and better performance. Thirdly, snapshot learning leads to consistent performance improvements independent of which architecture is used.
Effects of experimental hyperlipidaemia on the pharmacokinetics of docetaxel in rats

Hyperlipidaemia correlates with an increased risk of occurrence of various cancers. In this study, the effects of hyperlipidaemia on the pharmacokinetics of docetaxel, a member of the taxane class of anti-cancer drugs, were investigated in rats with experimental hyperlipidaemia; we focused on the alterations in docetaxel metabolism and plasma distribution. Docetaxel (5 mg/kg intravenously (i.v.) and 40 mg/kg per oral (p.o.)) was administered to control rats and rats with poloxamer-407 (P-407)–induced hyperlipidaemia (1 g/kg, intraperitoneally). In vitro studies were conducted on hepatic metabolism in S9 fractions and plasma protein binding using the ultrafiltration method. Hyperlipidaemia dramatically increased the area under the plasma concentration–time curve from time 0 to infinity (AUC0–∞) of docetaxel after i.v. (1.86-fold) or p.o. (10.8-fold) administration and decreased total body clearance (0.574-fold) and apparent volume of distribution at steady state (0.615-fold) of docetaxel after i.v. administration. Compared with the control rats, the metabolism of docetaxel by hepatic S9 fractions and the unbound fraction in the plasma in the hyperlipidaemic rats were decreased, i.e., by 20.1 and 79.8%, respectively. In conclusion, the alterations in docetaxel pharmacokinetics in rats with P-407-induced hyperlipidaemia may be due, at least in part, to a decrease in hepatic metabolism and the unbound fraction of docetaxel in the plasma. These findings have potential therapeutic implications for predicting human pharmacokinetic responses to hyperlipidaemia.
Construction of subspace codes through linkage

A construction is presented that allows to produce subspace codes of long length using subspace codes of shorter length in combination with a rank metric code. The subspace distance of the resulting code, called linkage code, is as good as the minimum subspace distance of the constituent codes. As a special application, the construction of the best known partial spreads is reproduced. Finally, for a special case of linkage, a decoding algorithm is presented which amounts to decoding with respect to the smaller constituent codes and which can be parallelized.
Regulation of glucocorticoid receptor in nasal polyps by systemic and intranasal glucocorticoids

Background: Poor response of nasal polyps to glucocorticoids (GCs) may be because of abnormal expression of GC receptors (GR) α and β or to downregulation of GRα. We aimed to evaluate the in vivo regulation of GR isoforms in GC‐treated nasal polyps and to assess the relationship between clinical response to GCs and GR levels.