Miracle-dz/UniFAR-FTUs huggingface dataset:
War Exposure, Attachment Style, and Moral Reasoning

This study extends the investigation of the effects of war exposure beyond those previously documented (e.g., increased stress and aggression and various types of psychopathology) to include moral reasoning. Three groups from two cultures with different levels of exposure to the 1998-1999 war in Kosovo were compared using Rest's Defining Issues Test. Possible effects of attachment style alone and in interaction with war exposure were also investigated. The results showed that exposure to war has (a) a very strong negative effect on moral reasoning with (b) no moderation by attachment style. However, the evidence suggests that war exposure may change the individual's attachment style from secure to insecure by inducing a more negative model of the other.
Single Nucleotide Polymorphism–Based Validation of Exonic Splicing Enhancers

Because deleterious alleles arising from mutation are filtered by natural selection, mutations that create such alleles will be underrepresented in the set of common genetic variation existing in a population at any given time. Here, we describe an approach based on this idea called VERIFY (variant elimination reinforces functionality), which can be used to assess the extent of natural selection acting on an oligonucleotide motif or set of motifs predicted to have biological activity. As an application of this approach, we analyzed a set of 238 hexanucleotides previously predicted to have exonic splicing enhancer (ESE) activity in human exons using the relative enhancer and silencer classification by unanimous enrichment (RESCUE)-ESE method. Aligning the single nucleotide polymorphisms (SNPs) from the public human SNP database to the chimpanzee genome allowed inference of the direction of the mutations that created present-day SNPs. Analyzing the set of SNPs that overlap RESCUE-ESE hexamers, we conclude that nearly one-fifth of the mutations that disrupt predicted ESEs have been eliminated by natural selection (odds ratio = 0.82 ± 0.05). This selection is strongest for the predicted ESEs that are located near splice sites. Our results demonstrate a novel approach for quantifying the extent of natural selection acting on candidate functional motifs and also suggest certain features of mutations/SNPs, such as proximity to the splice site and disruption or alteration of predicted ESEs, that should be useful in identifying variants that might cause a biological phenotype.
Prenatal Exposure to Traffic Pollution: Associations with Reduced Fetal Growth and Rapid Infant Weight Gain

Background: Prenatal air pollution exposure inhibits fetal growth, but implications for postnatal growth are unknown. Methods: We assessed weights and lengths of US infants in the Project Viva cohort at birth and 6 months. We estimated 3rd-trimester residential air pollution exposures using spatiotemporal models. We estimated neighborhood traffic density and roadway proximity at birth address using geographic information systems. We performed linear and logistic regression adjusted for sociodemographic variables, fetal growth, and gestational age at birth. Results: Mean birth weight-for-gestational age z-score (fetal growth) was 0.17 (standard deviation [SD] = 0.97; n = 2,114), 0- to 6-month weight-for-length gain was 0.23 z-units (SD = 1.11; n = 689), and 17% had weight-for-length ≥95th percentile at 6 months of age. Infants exposed to the highest (vs. lowest) quartile of neighborhood traffic density had lower fetal growth (−0.13 units [95% confidence interval (CI) = −0.25 to −0.01]), more rapid 0- to 6-month weight-for-length gain (0.25 units [95% CI = 0.01 to 0.49]), and higher odds of weight-for-length ≥95th percentile at 6 months (1.84 [95% CI = 1.11 to 3.05]). Neighborhood traffic density was additionally associated with an infant being in both the lowest quartile of fetal growth and the highest quartile of 0- to 6-month weight-for-length gain (Q4 vs. Q1, odds ratio = 3.01 [95% CI = 1.08 to 8.44]). Roadway proximity and 3rd-trimester black carbon exposure were similarly associated with growth outcomes. For 3rd-trimester particulate matter (PM2.5), effect estimates were in the same direction, but smaller and imprecise. Conclusions: Infants exposed to higher traffic-related pollution in early life may exhibit more rapid postnatal weight gain in addition to reduced fetal growth.
CD137 Is Expressed in Human Atherosclerosis and Promotes Development of Plaque Inflammation in Hypercholesterolemic Mice

Background— Atherosclerosis is a multifactorial disease in which inflammatory processes play an important role. Inflammation underlies lesion evolution at all stages, from establishment to plaque rupture and thrombosis. Costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40L and OX40/OX40L have been implicated in atherosclerosis. Methods and Results— This study shows that the tumor necrosis factor superfamily members CD137 and CD137 ligand (CD137L), which play a major role in several autoimmune diseases, may constitute a pathogenic pair in atherogenesis. We detected CD137 protein in human atherosclerotic lesions not only on T cells but also on endothelial cells and showed that CD137 in cultured endothelial cells and smooth muscle cells was induced by proinflammatory cytokines implicated in atherosclerosis. Activation of CD137 by CD137L induced adhesion molecule expression on endothelial cells and reduced smooth muscle cell proliferation. In addition, treatment of atherosclerosis-prone apolipoprotein E–deficient mice with a CD137 agonist caused increased inflammation. T-cell infiltration, mainly of CD8+ cells, and expression of the murine major histocompatibility complex class II molecule I-Ab increased significantly in atherosclerotic lesions, as did the aortic expression of proinflammatory cytokines. Conclusions— Taken together, these observations suggest that CD137-CD137L interactions in the vasculature may contribute to the progression of atherosclerosis via augmented leukocyte recruitment, increased inflammation, and development of a more disease-prone phenotype.
Intrinsic Motivation and Extrinsic Rewards: A Commentary on Cameron and Pierce’s Meta-Analysis

This article provides a critical analysis of Cameron and Pierce’s (1994) meta-analytic review of the experimental literature on the effects of extrinsic rewards on intrinsic motivation. It is suggested that Cameron and Pierce’s overly simplistic conclusion has little theoretical or practical value and is instead the direct consequence of their systematic and consistent misuse of meta-analytic procedures. A more nuanced analysis of the several different processes by which extrinsic rewards may affect motivation is also offered.
Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease: Implications for the pathophysiology of cortical function

We investigated the neurophysiological and clinical effects of repetitive magnetic stimulation (rTMS) delivered to the cortical motor areas in healthy subjects and patients with Parkinson's disease. rTMS was delivered with a high speed magnetic stimulator (Cadwell, Kennewick, WA) through a figure‐eight coil centred on the primary motor area at a stimulus intensity of 120% motor threshold. Trains of 10 stimuli were delivered at frequencies of 5 Hz while subjects were at rest and during a voluntary contraction of the contralateral first dorsal interosseous muscle. In normal subjects at rest, the muscle evoked responses (MEPs) to each stimulus in a train of magnetic stimuli progressively increased in size during the train. rTMS left the MEPs unchanged in patients off therapy and had a small facilitatory effect in those on therapy. In normal subjects and patients, 5‐Hz rTMS trains delivered during a voluntary contraction of the target muscle left the MEP unchanged in size. MEPs were followed by a silent period that increased in duration during the course of the train. The silent period duration increased to a similar extent in patients and controls. The reduced rTMS‐induced facilitation of MEPs in patients with Parkinson's disease reflects a decreased facilitation of the excitatory cells in the cortical motor areas. © 2002 Movement Disorder Society.
The Use of iPad Technology in the Kindergarten Classroom: A Quasi-Experimental Investigation of the Impact on Early Literacy Skills.

th Jan, 2014. The current investigation examined the impact of the use of iPad 2 literacy-based applications on the acquisition of emergent literacy skills in the areas of phonemic awareness and alphabetic principles. Achievement data was used to assess student gains in learning using the Dynamic Indicators of Basic Early Literacy Skills (DIBELS) Next Assessment. Data from a total of 281 kindergarten students was included in this year-long quasi-experimental investigation in which students in the treatment groups used early literacy reinforcing iPad applications to complement their traditional teacher delivered early literacy education, within kindergarten classroom learning centers. DIBELS scores demonstrated that 144 students in the treatment group show greater gains on higher learning skills of phoneme segmentation and nonsense word fluency, whereas 147 control group participants demonstrate greater gains on baseline data (first sound and letter naming fluency). Additional variables, such as student race, gender, socio-economic status and teacher experience were examined in an effort to better understand the impact of the iPad intervention.
User-Centric Participatory Sensing: A Game Theoretic Analysis

Participatory sensing (PS) is a novel and promising sensing network paradigm for achieving a flexible and scalable sensing coverage with a low deploying cost, by encouraging mobile users to participate and contribute their smartphones as sensors. In this work, we consider a general PS system model with location-dependent and time- sensitive tasks, which generalizes the existing models in the literature. We focus on the task scheduling in the user-centric PS system, where each participating user will make his individual task scheduling decision (including both the task selection and the task execution order) distributively. Specifically, we formulate the interaction of users as a strategic game called Task Scheduling Game (TSG) and perform a comprehensive game-theoretic analysis. First, we prove that the proposed TSG game is a potential game, which guarantees the existence of Nash equilibrium (NE). Then, we analyze the efficiency loss and the fairness index at the NE. Our analysis shows the efficiency at NE may increase or decrease with the number of users, depending on the level of competition. This implies that it is not always better to employ more users in the user-centric PS system, which is important for the system designer to determine the optimal number of users to be employed in a practical system.
How native is near-native? The issue of ultimate attainment in adult second language acquisition

A number of studies have reported that there is a negative correlation between age of L2 acquisition and performance on a variety of measures of L2 ability, and that individuals who begin learning an L2 after approximately 15 years of age fail to attain native-like levels of competence. These results have been interpreted as support both for the hypothesis that there is a critical period for L2 acquisition and for the hypothesis that there is a maturational decline in access to Universal Grammar (UG). We argue that extant results are not an adequate test of the critical periods hypothesis because they are based on the performance of learners who have not necessarily achieved native-like proficiency in the L2. In this study, we develop criteria to establish whether an L2 speaker has achieved native-like proficiency. We compare the performance of three groups (near-native speakers of English, non-native speakers and controls) on two tasks designed to tap aspects of UG which have been claimed to be subject to critical period effects. We found no significant differences between our near-native group and native speakers on either of the tasks. We conclude that native-like competence in an L2 is achievable, even by older L2 learners.
Forceful Phantom Firsts: Framing Experiences as Firsts Amplifies Their Influence on Judgment

First experiences are highly influential. Here, the authors show that nonfirst experiences can be made to seem like firsts and, consequently, to have a disproportionate influence on judgment. In six experiments, one piece of a series of information was framed to appear to have “first” status: For example, a weather report that appeared at the end of a sequence of weather reports happened to correspond to the first day of a vacation, and a customer review that appeared at the end of a sequence of hotel reviews happened to be the new year's first review. Such information had greater influence on subsequent judgments (e.g., of the next day's weather, of the hotel's quality) than identical information not framed as a first. This effect seems to arise largely because “phantom first” pieces of information receive greater weight, but not necessarily more attention, than other pieces of information.
CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12

Recently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3). In this study, we aimed to investigate the expression of CXCR7 in leukemic cells, as well as its participation in CXCL12 response. Interesting, we clearly demonstrated that CXCR7 is highly expressed in acute lymphoid leukemic cells compared with myeloid or normal hematopoietic cells and that CXCR7 contributed to T-acute lymphoid leukemic cell migration induced by CXCL12. Moreover, we showed that the cellular location of CXCR7 varied among T-lymphoid cells and this finding may be related to their migration capacity. Finally, we hypothesized that CXCR7 potentiates CXCR4 response and may contribute to the maintenance of leukemia by initiating cell recruitment to bone marrow niches that were once occupied by normal hematopoietic stem cells.
Magazine Exposure: Internalization, Self-Objectification, Eating Attitudes, and Body Satisfaction in Male and Female University Students

The relationships among magazine exposure, self-objectification, body shape dissatisfaction, and eating disorder symptomatology in men and women were investigated. Women reading beauty magazines and men reading fitness magazines internalized societal ideals (internalization). For women, beauty magazines predicted self-objectification, mediated by internalization. For men, only internalization predicted self-objectification. For men, fitness magazines predicted body shape dissatisfaction, mediated by internalization. For women, only internalization predicted body shape dissatisfaction. Reading magazines also predicted eating problems for men and women, for women this was mediated by internalization. These findings suggest that magazine reading is related to concerns with physical appearance and eating behaviours. Many of the relationships previously found for women are similar for men. A sociocultural model is used to explain these results.
Multiwavelength Study of Massive Galaxies at z~2. I. Star Formation and Galaxy Growth

Examining a sample of massive galaxies at 1.4 < z < 2.5 with KVega < 22 from GOODS, we compare photometry from Spitzer at mid- and far-IR to submillimeter, radio, and rest-frame UV wavelengths, to test the agreement between different tracers of star formation rates (SFRs) and to explore the implications for galaxy assembly. For z ~ 2 galaxies with moderate luminosities (L8 μm < 1011 L☉), we find that the SFR can be estimated consistently from the multiwavelength data based on local luminosity correlations. However, 20%-30% of massive galaxies, and nearly all those with L8 μm > 1011 L☉, show a mid-IR excess that is likely due to the presence of obscured active nuclei, as shown in a companion paper. There is a tight and roughly linear correlation between stellar mass and SFR for 24 μm-detected galaxies. For a given mass, the SFR at z = 2 was larger by a factor of ~4 and ~30 relative to that in star-forming galaxies at z = 1 and 0, respectively. Typical ultraluminous infrared galaxies (ULIRGs) at z = 2 are relatively "transparent" to ultraviolet light, and their activity is long lived (≳400 Myr), unlike that in local ULIRGs and high-redshift submillimeter-selected galaxies. ULIRGs are the common mode of star formation in massive galaxies at z = 2, and the high duty cycle suggests that major mergers are not the dominant trigger for this activity. Current galaxy formation models underpredict the normalization of the mass-SFR correlation by about a factor of 4 and the space density of ULIRGs by an order of magnitude but give better agreement for z > 1.4 quiescent galaxies.
Peptide-Induced Modulation of Synaptic Transmission and Escape Response in Drosophila Requires Two G-Protein-Coupled Receptors

Neuropeptides are found in both mammals and invertebrates and can modulate neural function through activation of G-protein-coupled receptors (GPCRS). The precise mechanisms by which many of these GPCRs modulate specific signaling cascades to regulate neural function are not well defined. We used Drosophila melanogaster as a model to examine both the cellular and behavioral effects of DPKQDFMRFamide, the most abundant peptide encoded by the dFMRF gene. We show that DPKQDFMRFamide enhanced synaptic transmission through activation of two G-protein-coupled receptors, Fmrf Receptor (FR) and Dromyosupressin Receptor-2 (DmsR-2). The peptide increased both the presynaptic Ca2+ response and the quantal content of released transmitter. Peptide-induced modulation of synaptic function could be abrogated by depleting intracellular Ca2+ stores or by interfering with Ca2+ release from the endoplasmic reticulum through disruption of either the ryanodine receptor or the inositol 1,4,5-trisphosphate receptor. The peptide also altered behavior. Exogenous DPKQDFMRFamide enhanced fictive locomotion; this required both the FR and DmsR-2. Likewise, both receptors were required for an escape response to intense light exposure. Thus, coincident detection of a peptide by two GPCRs modulates synaptic function through effects of Ca2+-induced Ca2+ release, and we hypothesize that these mechanisms are involved in behavioral responses to environmental stress.
A Theory-Building Investigation of the School-to-Work Transition

This study sought to enhance an understanding of the school-to-work transition for work-bound high school students. The objective was to identify individual and contextual factors relevant to the school-to-work transition. The authors obtained interview data from a diverse sample of 45 employed young men and women (aged 18-29) who have been in this transition during the past 10 years. Using a grounded theory approach, a coding system was developed with quantitative and qualitative indexes. The authors used job satisfaction and occupational choice congruence as subjective and objective means of capturing an adaptive school-to-work transition. Initial correlational analyses were conducted with quantitatively derived variables to provide a framework for qualitative analyses. Qualitative analyses of participant narratives revealed several individual and contextual factors that characterize the adaptive school-to-work transition. The article concludes with a discussion of the implications of these findings for career development theory as well as some propositions to guide future inquiry in this area.
Enterovirus 71 VPg Uridylation Uses a Two-Molecular Mechanism of 3D Polymerase

ABSTRACT VPg uridylylation is essential for picornavirus RNA replication. The VPg uridylylation reaction consists of the binding of VPg to 3D polymerase (3Dpol) and the transfer of UMP by 3Dpol to the hydroxyl group of the third amino acid Tyr of VPg. Previous studies suggested that different picornaviruses employ distinct mechanisms during VPg binding and uridylylation. Here, we report a novel site (Site-311, located at the base of the palm domain of EV71 3Dpol) that is essential for EV71 VPg uridylylation as well as viral replication. Ala substitution of amino acids (T313, F314, and I317) at Site-311 reduced the VPg uridylylation activity of 3Dpol by >90%. None of the Site-311 mutations affected the RNA elongation activity of 3Dpol, which indicates that Site-311 does not directly participate in RNA polymerization. However, mutations that abrogated VPg uridylylation significantly reduced the VPg binding ability of 3Dpol, which suggests that Site-311 is a potential VPg binding site on enterovirus 71 (EV71) 3Dpol. Mutation of a polymerase active site in 3Dpol and Site-311 in 3Dpol remarkably enables trans complementation to restore VPg uridylylation. In contrast, two distinct Site-311 mutants do not cause trans complementation in vitro. These results indicate that Site-311 is a VPg binding site that stabilizes the VPg molecule during the VPg uridylylation process and suggest a two-molecule model for 3Dpol during EV71 VPg uridylylation, such that one 3Dpol presents the hydroxyl group of Tyr3 of VPg to the polymerase active site of another 3Dpol, which in turn catalyzes VPg→VPg-pU conversion. For genome-length RNA, the Site-311 mutations that reduced VPg uridylylation were lethal for EV71 replication, which indicates that Site-311 is a potential antiviral target.
Ruling‐class Classification and Framing

Abstract This article discusses the relationships between school, higher education and work for pupils at public boarding schools. It uses the concepts of classification and framing developed by Basil Bernstein to illuminate the continuities and contradictions in experience of these pupils as they pass from school to university and into their careers. The role of these schools in the reproduction of the ruling class is shown to be related to the ability that these public boarding schools have to offer a mixture of both an integrated and collection type code. Finally, speculations are made about the possible effects of recent changes within these schools.
Longitudinal Analysis of the Antecedents of Emergent Spanish Literacy and Middle-School English Reading Achievement of Spanish-Speaking Students1

Among students entering kindergarten speaking Spanish, those with greater emergent Spanish literacy development and oral English proficiency were better able to maintain grade level performance in Spanish reading, transition more quickly to English reading, and attain a higher level of English reading proficiency in middle school. Non-English speaking student success in learning to read in English does not rest exclusively on primary language input and development, nor is it solely the result of rapid acquisition of English. Both apparently contribute to students' subsequent English reading achievement. Family factors predicting both early Spanish literacy and later English reading were parents' socioeconomic status and family literacy practices, as well as grandparents' educational level. Results suggest that early literacy experiences support subsequent literacy development, regardless of language; and time spent on literacy activity in the native language—whether it takes place at home or at school—is not time lost with respect to English reading acquisition, at least through middle school. The results also indicate the value of encouraging families to provide home literacy activities (in whatever languages they control) as well as formal preschool experiences.