Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence and origin of histologically confirmed liver metastases: an explorative case-study of 23,154 patients

Background The liver is a common metastatic site for a large variety of primary tumors. For both patients with known and unknown primary tumors it is important to understand metastatic patterns to provide tailored therapies. Objective To perform a nationwide exploration of the origins of histological confirmed liver metastases. Results A total of 23,154 patients were identified. The majority of liver metastases were carcinomas (n=21,400; 92%) of which adenocarcinoma was the most frequent subtype (n=17,349; 75%). Most common primary tumors in patients with adenocarcinoma were from colorectal (n=8,004), pancreatic (n=1,755) or breast origin (n=1,415). In women of 50 years and younger, metastatic adenocarcinoma originated more frequently from breast cancer, while in women older than 70 years liver metastases originated more frequently from gastrointestinal tumors. Liver metastases in men older than 70 years originated often from squamous cell lung carcinoma. An unknown primary tumor was detected in 4,209 (18%) patients, although tumor type could be determined in 3,855 (92%) of them. Methods Data were collected using the nationwide network and registry of histo- and cytopathology in the Netherlands (PALGA). All histological confirmed liver metastases between January 2001 and December 2010 were evaluated for tumor type, origin of the primary tumor and were correlated with patient characteristics (age, gender). Conclusion The current study provides an overview of the origins of liver metastases in a series of 23,154 patients.
Carcinogenic adducts induce distinct DNA polymerase binding orientations

DNA polymerases must accurately replicate DNA to maintain genome integrity. Carcinogenic adducts, such as 2-aminofluorene (AF) and N-acetyl-2-aminofluorene (AAF), covalently bind DNA bases and promote mutagenesis near the adduct site. The mechanism by which carcinogenic adducts inhibit DNA synthesis and cause mutagenesis remains unclear. Here, we measure interactions between a DNA polymerase and carcinogenic DNA adducts in real-time by single-molecule fluorescence. We find the degree to which an adduct affects polymerase binding to the DNA depends on the adduct location with respect to the primer terminus, the adduct structure and the nucleotides present in the solution. Not only do the adducts influence the polymerase dwell time on the DNA but also its binding position and orientation. Finally, we have directly observed an adduct- and mismatch-induced intermediate state, which may be an obligatory step in the DNA polymerase proofreading mechanism.
TESTBED MEASUREMENTS OF OPTIMIZED LINEAR DISPERSION CODES

High-rate optimized linear dispersion (LD) codes have been investigated extensively in theory and by simulation throughout the last years. Regardless of the findings of the research so far, little work has been performed to investigate the performance of such codes in a realistic transmission system. We implemented an optimized full-rate full-diversity space-time block code, derived by Damen, on the Vienna MIMO testbed for a 2 × 2 MIMO channel, and measured the uncoded bit error rate (BER) performance of the space-time block code, if decoded with a sphere decoder. Moreover, we compare the obtained results with the uncoded BER of the well-known Alamouti STBC, decoded with a ZF receiver, at various SNR values. Our results show that in a realistic environment highrate optimized LD codes offer no advantage over the conventional Alamouti STBC.
Pressure‐volume‐temperature equation of state of MgSiO3 perovskite from molecular dynamics and constraints on lower mantle composition

The composition of the lower mantle can be investigated by examining densities and seismic velocities of compositional models as functions of depth. In order to do this it is necessary to know the volumes and thermoelastic properties of the compositional constituents under lower mantle conditions. We determined the thermal equation of state (EOS) of MgSiO3 perovskite using the nonempirical variational induced breathing (VIB) interatomic potential with molecular dynamics simulations at pressures and temperatures of the lower mantle. We fit our pressure-volume-temperature results to a thermal EOS of the form P(V, T) = P0(V, T0) + ΔPth(T), where T0 = 300 K and P0 is the isothermal Universal EOS. The thermal pressure ΔPth can be represented by a linear relationship ΔPth = a + bT. We find V0 = 165.40 A3, KT0 = 273 GPa, KT0′ = 3.86, a = −1.99 GPa, and b = 0.00664 GPa K−1 for pressures of 0–140 GPa and temperatures of 300–3000 K. By fixing V0 to the experimentally determined value of 162.49 A3 and calculating density and bulk sound velocity profiles along a lower mantle geotherm we find that the lower mantle cannot consist solely of (Mg,Fe)SiO3 perovskite with XMg ranging from 0.9–1.0. Using pyrolitic compositions of 67 vol % perovskite (XMg = 0.93–0.96) and 33 vol % magnesiowustite (XMg = 0.82–0.86), however, we obtained density and velocity profiles that are in excellent agreement with seismological models for a reasonable geotherm.
Phenotypic and Genetic Associations Between the Big Five and Trait Emotional Intelligence

Abstract This study reports the first behavioral genetic investigation of the extent to which genetic and/or environmental factors contribute to the relationship between the Big Five personality factors and trait emotional intelligence. 213 pairs of adult monozygotic twins and 103 pairs of same-sex dizygotic twins completed the NEO-PI-R and the Trait Emotional Intelligence Questionnaire (TEIQue). Replicating previous non-twin studies, many significant phenotypic correlations were found between the Big Five factors — especially Neuroticism, Extraversion, and Conscientiousness — and the facets, factors, and global scores derived from the TEIQue. Bivariate behavioral genetic model-fitting analyses revealed that these phenotypic correlations were primarily attributable to correlated genetic factors and secondarily to correlated non-shared environmental factors. The results support the feasibility of incorporating EI as a trait within existing personality taxonomies.
Healthy and Safe Workplaces in Health Care : examining the role of safety climate

Working in health care involves significant health and safety risks. This dissertation uses health care utilization data of Dutch employees working in health care as a starting point to investigate variation in employee health and safety across organizations. It furthermore examines the role safety climate plays in explaining these differences. Safety climate can be described as employees’ perceptions of the policies, procedures and practices as it relates to the value and importance of physical and psychological health and safety within the organization. The results show that an organization’s safety climate is related to various outcomes at the individual level, such as employee health and behavior. At the organizational level, the results demonstrate that health care organizations with a more positive safety climate also have lower absenteeism, presenteeism and employee health care utilization rates. Based on these findings, a multifaceted safety climate intervention program was developed and empirically tested in five health care organizations. The results of this study indicate that the multifaceted safety climate intervention positively influences safety climate perceptions and behavior in the workplace. The findings furthermore reveal that attention needs to be paid to the implementation process, especially to the role of the direct supervisor and the actual changes in the workplace the intervention brings about. This dissertation thus contributes to the scientific knowledge on the effects of safety climate and provides practical recommendations on how to improve safety climate and achieve healthy and safe workplaces in health care.
CBITS: Cognitive Behavioral Intervention for Trauma in Schools

Aspects of culture or group experiences that are addressed (e.g., faith/spiritual component, transportation barriers): During the CBITS training and ongoing consultation with sites, we have specifically included in our training ways to implement this program to address cultural competency. We encourage sites to use culturally appropriate examples during the treatment, and we discuss the cultural issues pertinent to each trainee’s site. Although there are examples for each of the exercises in the manual, clinicians are encouraged to substitute these for culturally salient ones. For example, in working with immigrant populations, we focused some of the parent sessions on separation and loss issues that so many had experienced during the migration process. When we’ve worked in Catholic schools, faith-based clinicians openly discussed the students’ examples of coping through prayer and complementing this with CBT skills.
Organisational factors: impacting on health for ambulance personnel

Purpose The purpose of this paper is to establish if organisational factors are leading to a negative effect on ambulance personnel’s health. In recent years, frontline ambulance personnel have displayed a consistent high rate of sickness amongst healthcare workers within the National Health Service in the UK. Post-traumatic stress disorder (PTSD) has previously been cited, but organisational factors may be stressors to health. Design/methodology/approach A search of electronic databases MEDLINE EBSCO, MEDLINE OVID, MEDLINE PUBMED, AMED, CINAHL, Web of Science, Zetoc within the time period of 2000–2017 resulted in six mixed methods studies. Hand searching elicited one further study. The literature provided data on organisational and occupational stressors (excluding PTSD) relating to the health of 2,840 frontline ambulance workers in the UK, Australia, Norway, the Netherlands and Canada. The robust quantitative data were obtained from validated questionnaires using statistical analysis, whilst the mixed quality qualitative data elicited similar themes. Narrative synthesis was used to draw theories from the data. Findings Organisational factors such as low job autonomy, a lack of supervisor support and poor leadership are impacting on the health and well-being of frontline ambulance workers. This is intertwined with the occupational factors of daily operational demands, fatigue and enforced overtime, so organisational changes may have a wider impact on daily occupational issues. Originality/value The findings have possible implications for re-structuring organisational policies within the ambulance service to reduce staff sickness.
Reputation, subjective well-being, and environmental responsibility: the role of satisfaction and identification

ABSTRACT Based on signaling theory, this study investigates how the perceived reputation of a destination impacts the environmentally responsible behavior (ERB) and subjective well-being (SWB) of tourists through satisfaction and identification with a destination, respectively. The findings support the proposed behavioral model. A total of 539 valid questionnaires were obtained from tourists to a natural ecology and historical culture destination in China and analyzed. The results show that destination reputation has a direct impact on tourists' satisfaction and identification with the destination. Satisfaction and identification with the destination both partially mediate the effect of perceived destination reputation on tourists' ERB and SWB. Findings suggest that enhancing perceptions of a destination's reputation is an important step in increasing tourists' SWB and strengthening their engagement in ERB. Discussion of the findings, research implications, and future research directions are provided.
Social Class, Solipsism, and Contextualism: How the Rich Are Different from the Poor Empirical Traditions in the Study of Social Class

Social class is shaped by an individual's material resources as well as perceptions of rank visa `-vis others in society, and in this article, we examine how class influences behavior. Diminished resources and lower rank create contexts that constrain social outcomes for lower-class individuals and enhance contextualist tendencies—that is, a focus on external, uncontrollable social forces and other individuals who influence one's life outcomes. In contrast, abundant resources and elevated rank create contexts that enhance the personal freedoms of upper-class individuals and give rise to solipsistic social cognitive tendencies—that is, an individualistic focus on one's own internal states, goals, motivations, and emotions. Guided by this framework, we detail 9 hypotheses and relevant empirical evidence concerning how class-based con-textualist and solipsistic tendencies shape the self, perceptions of the social environment, and relationships to other individuals. Novel predictions and implications for research in other socio-political contexts are considered. In what is now known to be an apocryphal conversation, F. Scott Fitzgerald noted to his friend Ernest Hemingway that " The rich are different from the poor. " Hemingway's response: " Yes, they have more money. " It goes without saying that the lives of the rich and poor are different. For more than 100 years, social scientists have known that social class is a profound dimension of social life (e. Within psychological science , research has shown that social class influences a diverse array of domains that include aesthetic preferences Notwithstanding these findings, psychological science has yet to fully offer a response to Fitzgerald's observation that the rich are different from the poor. A theory of how social class shapes basic psychological processes has not been fully articulated. The aim of the present article is to provide such a theory, a social cognitive theory of social class. We contend that an indi-vidual's social class is a context rooted in both the material substance of social life (wealth, education, work) and the individ-ual's construal of his or her class rank, and is a core aspect of how he or she thinks of the self and relates to the social world. Our central argument is that social class contexts elicit reliable social cognitive patterns among lower-class individuals— characterized by a contextual, externally-oriented cognitive and relational orientation to the world—and upper-class individuals— characterized by a solipsistic, individualistic cognitive and relational orientation to the world. Guided by this analysis, we review several specific predictions and the …
Investigating the cross-cultural dimensions of educational Web 2.0 acceptance: the case of Moroccan and American university students

As a response to scholars’ growing calls for new and more cross-cultural perspectives in the study of educational technology acceptance, this study examined the moderating effect of Moroccan (n = 200) and American (n = 200) university students’ psycho-cultural values, as conceptualized by Hofstede’s multidimensional matrix, on their acceptance and use of Web 2.0 for learning. Data were collected using an extended version of the unified theory of acceptance and use of technology (UTAUT). The findings, in addition to validating the UTAUT in two culturally divergent higher education contexts, have uncovered how students’ cultural values of individualism/collectivism and power distance significantly affect their Web 2.0 acceptance profiles. Thus, for example, while Moroccan students’ acceptance of Web 2.0 is determined by social influence, performance expectancy and behavioral intention were the primary determinant factors for their American counterparts.
Physical Design Automation for 3D Chip Stacks: Challenges and Solutions

The concept of 3D chip stacks has been advocated by both industry and academia for many years, and hailed as one of the most promising approaches to meet ever-increasing demands for performance, functionality and power consumption going forward. However, a multitude of challenges has thus far obstructed large-scale transition from "classical" 2D chips to stacked 3D chips. We survey major design challenges for 3D chip stacks with particular focus on their implications for physical design. We also derive requirements for advances in design automation, such as the need for a unified workflow. Finally, we outline current promising solutions as well as areas needing further research and development.
Agreement Between Bayley-III Measurements and WISC-IV Measurements in Typically Developing Children

The study aim was to explore the relationship between a developmental assessment at preschool age and an intelligence quotient (IQ) assessment at school age. One hundred sixty-two children were assessed at 2.5 years with the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley-III) and then at 6.5 years with the Wechsler Intelligence Scale for Children—Fourth Edition (WISC-IV). The Bayley-III Cognitive Index score was the Bayley entity that showed the highest correlation with WISC-IV Full-Scale IQ (FSIQ; r = .41). There was a significant difference between the individual WISC-IV FSIQ and the Bayley-III Cognitive Index scores. Analyses showed an average difference of −4 units and 95% limits of agreement of −18.5 to 26.4 units. A multivariate model identified the Bayley-III Cognitive Index score as the most important predictor for FSIQ and General Ability Index (GAI), respectively, in comparison with demographic factors. The model explained 24% of the total FSIQ variation and 26% of the GAI variation. It was concluded that the Bayley-III measurement was an insufficient predictor of later IQ.
Organizational Commitment of High School Teachers.

The aim of this study is to identify high school teachers’ commitment to school development, colleagues, the teaching profession and sense of duty. The population of this descriptive survey comprised 2,805 teachers working at 47 high schools in Elazig during the 2016-2017 school year. The study sample was selected through stratified sampling, which aims to identify subgroups in a population and ensure that their size in the sample represents their proportion in the population. The data collection tool was then distributed to 461 teachers working in 12 schools selected randomly from these strata. The data collection tool had two sections. The first had conceptual questions and the second had questions about organizational commitment behaviors. The results showed that high school teachers felt full commitment only to the teaching profession, while they “often” felt committed in other subdimensions and the entire scale. More precisely, the commitment level of science teachers to school development was higher than that of social sciences teachers. Teachers working in the city center had higher commitment to colleagues and school development than those in small towns. Teacher candidates had higher commitment to sense of duty than teachers and specialist teachers. Teachers working at vocational and technical high schools had lower commitment to school development than teachers working at Anatolian high schools, social sciences and science high schools. There was a moderate, negative and meaningful relationship between teachers’ age, professional seniority, professional title and marital status. There was a high, positive and meaningful relationship between the subdimensions and the entire scale. Among the subdimensions, too, there was a moderate, positive and meaningful relationship.
Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects.

We have attempted to determine whether interleukin-5 (IL-5), a cytokine that selectively affects eosinophil (as opposed to neutrophil) differentiation and activation, also modulates eosinophil migrational responses. Using a modified Boyden chemotaxis assay, IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gave a weak locomotory response for eosinophils from normal nonatopic subjects (optimal at 10(-11), 10(-8), and 10(-9) mol/L, respectively), but not for eosinophils from subjects with an eosinophilia associated with asthma and/or allergic rhinitis. In contrast, IL-5 and IL-3 had no effect on neutrophils, while GM-CSF was chemotactic for neutrophils over a limited concentration range, optimal at 10(-8) mol/L. When eosinophils from normal subjects were incubated with IL-5 (10(-9) mol/L), the locomotory response to platelet-activating factor (PAF; 10(-8) mol/L, P less than . 05), leukotriene B4 (LTB4; 10(-6) mol/L, P less than . 01), and N-formyl-methionyl-leucyl-phenylalanine (FMLP; 10(-8) mol/L, P less than . 01) was significantly enhanced. The percentage enhancement of eosinophil locomotion by IL-5 was greater for eosinophils from normal as compared with subjects with an eosinophilia associated with asthma (P less than .05 for PAF and LTB4; P less than .01 for FMLP). Preincubation of eosinophils from normal subjects with IL-5 (10(-9) mol/L) attenuated the subsequent locomotory response to IL-5 (10(-12) and 10(-11) mol/L, P less than . 05). Therefore, the observed refractoriness of eosinophils from eosinophilic subjects to both directional migratory and priming effects of IL-5 in vitro, may reflect a deactivation process resulting from prior exposure in vivo. The selective priming of eosinophil but not neutrophil locomotion by IL-5 suggests that this cytokine may play a significant role in the preferential accumulation of eosinophils at sites of allergic inflammation.
Skeletal Muscle myomiR Are Differentially Expressed by Endurance Exercise Mode and Combined Essential Amino Acid and Carbohydrate Supplementation

Skeletal muscle microRNAs (myomiR) expression is modulated by exercise, however, the influence of endurance exercise mode, combined with essential amino acid and carbohydrate (EAA+CHO) supplementation are not well defined. This study determined the effects of weighted versus non-weighted endurance exercise, with or without EAA+CHO ingestion on myomiR expression and their association with muscle protein synthesis (MPS). Twenty five adults performed 90 min of metabolically-matched (2.2 VO2 L·m−1) load carriage (LC; performed on a treadmill wearing a vest equal to 30% of individual body mass) or cycle ergometry (CE) exercise, during which EAA+CHO (10 g EAA and 46 g CHO) or non-nutritive control (CON) drinks were consumed. Expression of myomiR (RT-qPCR) were determined at rest (PRE), immediately post-exercise (POST), and 3 h into recovery (REC). Muscle protein synthesis (2H5-phenylalanine) was measured during exercise and recovery. Relative to PRE, POST, and REC expression of miR-1-3p, miR-206, miR-208a-5, and miR-499 was lower (P < 0.05) for LC compared to CE, regardless of dietary treatment. Independent of exercise mode, miR-1-3p and miR-208a-5p expression were lower (P < 0.05) after ingesting EAA+CHO compared to CON. Expression of miR-206 was highest for CE-CON than any other treatment (exercise-by-drink, P < 0.05). Common targets of differing myomiR were identified as markers within mTORC1 signaling, and miR-206 and miR-499 were inversely associated with MPS rates immediately post-exercise. These findings suggest the alterations in myomiR expression between exercise mode and EAA+CHO intake may in part be due to differing MPS modulation immediately post-exercise.