Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiovascular adjustments in normal newborn lambs.

The fetal and newborn lamb has been the subject of a great deal of experimental investigation, and the results obtained from these studies have been used to make analogies with human newborns where direct observations have been few.1,2Many of the observations on lambs have been made under experimental conditions which undoubtedly have changed the normal resting physiological state, and the usual sequence of perinatal events may have, therefore, been interrupted or distorted. Indicator-dilution techniques of studying the cardiovascular system can be performed in the intact, unanesthetized animal or man with minimal disturbance of the hemodynamics. These techniques were chosen for the study of the neonatal hemodynamic adjustments of normal unanesthetized lambs lying quietly either sleeping or sucking on a sugar nipple. These same techniques may be directly applicable to the study of human newborn infants with less risk than cineangiography. Methods and Materials Nine normal lambs were studied
Impulsiveness and Cigarette Smoking

Objective: Varying aspects of impulsive personality have been associated with tobacco use in cross-sectional and prospective studies, including novelty seeking and (low) constraint but most studies have not examined more than one tobacco use phenotype (e.g., any tobacco use versus dependence) or considered more than one variety of impulsiveness simultaneously. Methods: The current study was conducted to evaluate the association of impulsive personality features with multiple tobacco use phenotypes including smoking status, lifetime tobacco consumption, and dependence in a sample of 1284 adults between the ages of 30 and 54. Participants completed multiple self-report measures of impulsive personality and were interviewed regarding lifetime tobacco use. Results: Results revealed that reward seeking and disinhibitory traits were both associated with smoking status but only disinhibition was associated with tobacco dependence, after controlling for reward seeking. Conclusions: The results reported here may aid investigations aimed at identifying neurobiological, including genetic, correlates of tobacco use and dependence by providing potential behavioral correlates of the diversity of tobacco use phenotypes. Moreover, successful efforts to prevent tobacco-related disease through prevention or cessation programs will be facilitated by the identification of factors that are differentially associated with different smoking phenotypes. TCI = Temperament and Character Inventory; NS = Novelty Seeking; ZSS = Zuckerman Sensation Seeking Scale; BIS = Barratt Impulsiveness Scale.
The Functional Integration and the Two-Point Correlation Functions of the Trapped Bose Gas

A quantum field-theoretical model, which describes spatially non-homogeneous repulsive Bose gas in an external harmonic potential is considered. Two-point thermal correlation functions of the Bose gas are calculated in the framework of the functional integration approach. Successive integration over the ``high-energy'' functional variables first and then over the ``low-energy'' ones is used. The effective action functional for the low-energy variables is obtained in one loop approximation. The functional integral representations for the correlation functions are estimated by means of the stationary phase approximation. A power-law asymptotical behaviour of the correlators of the one-dimensional Bose gas is demonstrated in the limit, when the temperature is going to zero, while the volume occupied by the non-homogeneous Bose gas infinitely increases. The power-law behaviour is governed by the critical exponent dependent on the spatial arguments.
I2R multi-pass machine translation system for IWSLT 2008.

In this paper, we describe the system and approach used by the Institute for Infocomm Research (I 2 R) for the IWSLT 2008 spoken language translation evaluation campaign. In the system, we integrate various decoding algorithms into a multipass translation framework. The multi-pass approach enables us to utilize various decoding algorithm and to explore much more hypotheses. This paper reports our design philosophy, overall architecture, each individual system and various system combination methods that we have explored. The performance on development and test sets are reported in detail in the paper. The system has shown competitive performance with respect to the BLEU and METEOR measures in Chinese-English Challenge and BTEC tasks.
Impact of Assimilating Himawari‐8‐Derived Layered Precipitable Water With Varying Cumulus and Microphysics Parameterization Schemes on the Simulation of Typhoon Hato

Understanding moisture information ahead of tropical cyclone (TC) convection is very important for predicting TC track, intensity, and precipitation. The advanced Himawari imager onboard the Japanese Himawari‐8/‐9 satellite can provide high spatial and temporal resolution moisture information. Three‐layered precipitable water (LPW) with its three water vapor absorption infrared bands can be assimilated to generate better understanding and prediction of TC evolution. The impacts of LPW assimilation in the Weather Research and Forecasting model with nine combinations of physical parameterization schemes, including three cumulus parameterization (CP) and three microphysics parameterization (MP) schemes on TC prediction, have been comprehensively analyzed using Typhoon Hato as a case study. The results indicate that LPW assimilation reduces the average track error and speed up TC movement by better adjustment of the atmospheric circulation fields via changing the vertical structure of moisture and thermal profile. The track forecasts retain sensitivity to CP schemes after LPW assimilation. Also, LPW assimilation improves TC intensity prediction because the latent heat release process is accurately adjusted. It has been revealed that LPW assimilation can weaken the intensity sensitivity to MP schemes more than to CP schemes. Skill scores were used to evaluate precipitation forecasts after Hato's landfall. The results indicate that heavy precipitation forecasts are more sensitive to the choice of MP schemes. After LPW assimilation, the equitable threat scores among different results become similar and all forecast skills are increased. In addition, group statistic results with different initial time show the same conclusions.
Satisfaction Level of Inpatient Food Services for Patients at RSUD Meuraxa Hospital in Banda Aceh

Hospitals are one of the crucial healthcare facilities that play a vital role in supporting healthcare efforts. Patient satisfaction or dissatisfaction is significantly influenced by the expected quality of services, particularly in hospitals. One of the success indicators in nutritional services is the satisfaction level of patients with the food they receive, as it positively contributes to the patients' healing process. These efforts also play a crucial role in supporting the recovery of patients. This research aims to assess the level of satisfaction with food services in terms of taste, presentation, and serving among inpatients at RSUD Meuraxa in Banda Aceh. The research method employed is descriptive quantitative research, aiming to provide an overview of patient satisfaction with food services at RSUD Meuraxa. Data were collected from 50 randomly selected respondents using an instrument that utilized a Likert scale with four options. The results of this study indicate that the majority of respondents are highly satisfied with the food services. A total of 90.0% of respondents stated that the food served at the hospital is delicious. Additionally, 70.0% of respondents found the food presentation to be appealing, and 96% of respondents considered the food serving to be excellent for inpatients at RSUD Meuraxa. Of all the satisfaction aspects measured, 86.0% of respondents expressed their satisfaction with the food services provided to inpatients at the hospital.
Follicular conjunctivitis caused by Chlamydia trachomatis in an infant Saharan population: molecular and clinical diagnosis

Aims: To ascertain the prevalence of acute trachoma as a supposed endemic disease among infants in the Saharan refugee camps of Tindouf (Algeria) and to evaluate the efficacy of treatment with a single dose of azithromycin. Methods: 527 children aged between 3 and 17 were evaluated in the camp schools in October 2001. All the children were clinically and microbiologically examined, including slit lamp checks of anterior segment and two conjunctival swabs, one for the detection of membrane lipopolysaccharide by quick immunoassay test Clearview Chlamydia MF and the other for the detection of specific DNA by chlamydia plasmid specific polymerase chain reaction (PCR) assay. After examination, a single dose of azithromycin was administered to each child. One month later samples from positive children and 12 random negative children by the first PCR were taken to perform a new PCR assay. Results: Chlamydia trachomatis was suspected in 2.47% of the children, papillary hypertrophy being the most frequently seen clinical sign. Scarring changes secondary to trachoma were detected in 11.7% of the children. Only four cases (0.8%) were positive to the immunoassay test and 12 cases (2.27%) were positive by PCR. After treatment a second PCR was performed on positive children and they were negative of chlamydia DNA amplification. However, one child who was negative and received the treatment was positive in the second PCR assay. Conclusion: Acute trachoma prevalence is much lower than expected among infants in this Saharan population. The possible reasons could be the recent improvements in hygiene and health care. Cicatricial trachoma is more frequent. The Clearview immunoassay test has very low sensitivity in the detection of this disease. A single dose of azithromycin is sufficient to treat chlamydial conjunctivitis. However, a programme of improvement in hygiene and health care is necessary to prevent re-infection.
Stock price prediction based on stock-specific and sub-industry-specific news articles

Accurate forecasting of upcoming trends in the capital markets is extremely important for algorithmic trading and investment management. Before making a trading decision, investors estimate the probability that a certain news item will influence the market based on the available information. Speculation among traders is often caused by the release of a breaking news article and results in price movements. Publications of news articles influence the market state that makes them a powerful source of data in financial forecasting. Recently, researchers have developed trend and price prediction models based on information extracted from news articles. However, to date no previous research that investigates the advantages of using news articles with different levels of relevance to the target stock has been conducted. This research study uses the multiple kernel learning technique to effectively combine information extracted from stock-specific and sub-industry-specific news articles for prediction of an upcoming price movement. News articles are divided into these two categories based on their relevance to a targeted stock and analyzed by separate kernels. The experimental results show that utilizing two categories of news improves the prediction accuracy in comparison with methods based on a single news category.
Efficient Non-Viral Ocular Gene Transfer with Compacted DNA Nanoparticles

Background The eye is an excellent candidate for gene therapy as it is immune privileged and much of the disease-causing genetics are well understood. Towards this goal, we evaluated the efficiency of compacted DNA nanoparticles as a system for non-viral gene transfer to ocular tissues. The compacted DNA nanoparticles examined here have been shown to be safe and effective in a human clinical trial, have no theoretical limitation on plasmid size, do not provoke immune responses, and can be highly concentrated. Methods and Findings Here we show that these nanoparticles can be targeted to different tissues within the eye by varying the site of injection. Almost all cell types of the eye were capable of transfection by the nanoparticle and produced robust levels of gene expression that were dose-dependent. Most impressively, subretinal delivery of these nanoparticles transfected nearly all of the photoreceptor population and produced expression levels almost equal to that of rod opsin, the highest expressed gene in the retina. Conclusions As no deleterious effects on retinal function were observed, this treatment strategy appears to be clinically viable and provides a highly efficient non-viral technology to safely deliver and express nucleic acids in the retina and other ocular tissues.
Model-Based Analysis of Electric Drive Options for Medium-Duty Parcel Delivery Vehicles: Preprint

Medium-duty vehicles are used in a broad array of fleet applications, including parcel delivery. These vehicles are excellent candidates for electric drive applications due to their transient-intensive duty cycles, operation in densely populated areas, and relatively high fuel consumption and emissions. The National Renewable Energy Laboratory (NREL) conducted a robust assessment of parcel delivery routes and completed a model-based techno-economic analysis of hybrid electric vehicle (HEV) and plug-in hybrid electric vehicle configurations. First, NREL characterized parcel delivery vehicle usage patterns, most notably daily distance driven and drive cycle intensity. Second, drive-cycle analysis results framed the selection of drive cycles used to test a parcel delivery HEV on a chassis dynamometer. Next, measured fuel consumption results were used to validate simulated fuel consumption values derived from a dynamic model of the parcel delivery vehicle. Finally, NREL swept a matrix of 120 component size, usage, and cost combinations to assess impacts on fuel consumption and vehicle cost. The results illustrated the dependency of component sizing on drive-cycle intensity and daily distance driven and may allow parcel delivery fleets to match the most appropriate electric drive vehicle to their fleet usage profile.
Single-Step Multiplex PCR Assay for Determining 92 Pneumococcal Serotypes

ABSTRACT For pneumococcal disease surveillance, simple and cost-effective methods capable of determining all serotypes are needed. Combining a single-tube multiplex PCR with fluorescently labeled primers followed by amplicon analysis using automated fluorescent capillary electrophoresis, each serotype of 92 reference isolates and 297 recently collected clinical isolates was successfully determined.
Chest Wall Perforator Flap Partial Breast Reconstruction: A Retrospective Analysis of Surgical, Cosmetic and Survival Outcome

Introduction: Oncoplastic breast surgery includes volume replacement as well as volume displacement. Autologous tissue is the preferred approach for volume replacement and includes chest wall perforator flaps (CWPF). Although described more than a decade ago, CWPFs have not been adopted widely in clinical practice till recently. We report the largest single-centre institutional data on CWPFs. Patients and methods: The study includes all patients who underwent breast conservation surgery (BCS) using CWPFs from January 2015 to December 2022. Data were retrieved from the institutional electronic record and Redcap database. The analysis was done using SPSS 23 and STATA 14. Results: 150 patients were included in the study. The mean age was 48.8 years (SD 10.4), and the body mass index was (26.6 kg/m 2 , SD 4.3). >50% of patients had breasts with small cup sizes (A&B) and mild ptosis (Non-ptotic and Grade 1 ptosis). 44.7% of patients underwent lateral intercostal artery perforator flap (LICAP), anterior intercostal artery perforator flap in 31.3%, lateral thoracic perforator flap (LTAP) in 12%, LICAP + LTAP in 11.3% and thoracodorsal artery perforator flap in 1%. Post-operatively, haematoma was seen in 1.3%, complete flap necrosis in 1.3%, seroma in 7%, wound dehiscence in 12%, and positive margin in 6.7%. 92 patients responded to the satisfaction assessment, of which >90% were happy with the surgical scars, comfortable going out in a public place, satisfied with the symmetry of the breast, and no one chose mastectomy in hindsight. The 5-year predicted disease free survival and overall survival were 86.4% and 94.7%, respectively. Conclusion: BCS with CWPF is an excellent option for reconstruction in small to medium-sized breasts. It is associated with minimal morbidity and comparable patient-reported cosmetic and survival outcomes.
Competition among Alternative Option Market Structures: Evidence from Eurex vs. Euwax

We study option market design by providing a theoretical motivation and comprehensive empirical analysis of two fundamentally different option market structures, the Eurex derivatives exchange and Euwax, the world’s largest market for bank-issued options. These markets exist side-by- side, offering many options with identical or similar characteristics. We motivate the two market structures based on option investor clienteles which differ with respect to the probability of selling the option back to the dealer/issuer before maturity, which in turn affects the investors expected transaction costs. As suggested by the clientele argument, the most important empirical finding is that Euwax ask prices and bid prices are consistently higher than comparable Eurex ask prices and bid prices. The difference of the bid prices is larger, resulting in smaller Euwax bid-ask spreads, which makes Euwax preferable for investors with a high probability of early liquidation. We find that competition from one market reduces bid-ask spreads in the other market.
Do people with ME/CFS and joint hypermobility represent a disease subgroup? An analysis using registry data

Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, multifaceted disease that affects millions globally. Despite its significant impact, the disease's etiology remains poorly understood, and symptom heterogeneity poses challenges for diagnosis and treatment. Joint hypermobility, commonly seen in hypermobile Ehlers-Danlos Syndrome (hEDS), has been observed in ME/CFS patients but its prevalence and clinical significance within this population are not well-characterized. Objective To compare the characteristics of ME/CFS patients with and without joint hypermobility (JH+ and JH-) as assessed using the Beighton scoring system, and to explore whether JH+ ME/CFS patients exhibit distinct disease characteristics, comorbidities, and health-related quality of life (HRQOL). Methods The study used cross-sectional, self-reported data from 815 participants of the You + ME Registry. Participants were categorized as JH+ or JH- based on self–assessed Beighton scores and compared across demographics, comorbidities, family history, and symptoms. HRQOL was assessed using the Short Form-36 RAND survey and Karnofsky Performance Status. Results 15.5% (N = 126) of participants were classified as JH+. JH+ participants were more likely to be female, report Ehlers-Danlos Syndrome (EDS), Postural Orthostatic Tachycardia Syndrome (POTS), and a family history of EDS. They experienced worse HRQOL, particularly in physical functioning and pain, and a higher number of autonomic, neurocognitive, headache, gut, and musculoskeletal symptoms. Sensitivity analysis suggested that ME/CFS with concurrent JH+ and EDS was associated with more severe symptoms and greater functional impairment. Conclusion ME/CFS patients with joint hypermobility, particularly those with EDS, demonstrate distinct clinical characteristics, including more severe symptomatology and reduced HRQOL. These findings highlight the need for comprehensive clinical assessments of ME/CFS patients with joint hypermobility. Understanding these relationships could aid in subgroup identification, improving diagnosis, and informing targeted therapeutic approaches. Further research is warranted to explore these associations and their implications for clinical practice.
MDL-Based Decision Tree Pruning

This paper explores the application of the Minimum Description Length principle for pruning decision trees. We present a new algorithm that intuitively captures the primary goal of reducing the misclassification error. An experimental comparison is presented with three other pruning algorithms. The results show that the MDL pruning algorithm achieves good accuracy, small trees, and fast execution times.
Evaluation of a workshop to capture knowledge from subject matter experts in maritime surveillance

This paper reports on a brainstorming workshop with subject matter experts that aimed at identifying potential anomalies for world wide maritime surveillance. An extensive description of the workshop process and output is presented. The evaluation consists of two parts. First, the output of the workshop is compared with the output of a similar workshop as presented in Roy [1]. Secondly, the methodological differences between capturing know-how of subject matter experts in a workshop versus observing daily work of operators, as applied in Nilsson et al [2], is discussed. The conclusions are that brainstorming workshops and field studies should be combined to compensate for their weaknesses. Also, the outcomes of both methods heavily depend on the selection of operators to be observed, respectively the selection of subject matter experts invited. A final recommendation is that multiple studies and workshops are needed until no ‘new’ anomalies are identified.
Effect of Polygodial on the Mitochondrial ATPase of Saccharomyces cerevisiae

ABSTRACT The fungicidal mechanism of a naturally occurring sesquiterpene dialdehyde, polygodial, was investigated in Saccharomyces cerevisiae. In an acidification assay, polygodial completely suppressed the glucose-induced decrease in external pH at 3.13 μg/ml, the same as the fungicidal concentration. Acidification occurs primarily through the proton-pumping action of the plasma membrane ATPase, Pma1p. Surprisingly, this ATPase was not directly inhibited by polygodial. In contrast, the two other membrane-bound ATPases in yeast were found to be susceptible to the compound. The mitochondrial ATPase was inhibited by polygodial in a dose-dependent manner at concentrations similar to the fungicidal concentration, whereas the vacuolar ATPase was only slightly inhibited. Cytoplasmic petite mutants, which lack mitochondrial DNA and are respiration deficient, were significantly less susceptible to polygodial than the wild type, as was shown in time-kill curves. Apet9 mutant which lacks a functional ADP-ATP translocator and is therefore respiration dependent was rapidly inhibited by polygodial. The results of these susceptibility assays link enzyme inhibition to physiological effect. Previous studies have reported that plasma membrane disruption is the mechanism of polygodial-induced cell death; however, these results support a more complex picture of its effect. A major target of polygodial in yeast is mitochondrial ATP synthase. Reduction of the ATP supply leads to a suppression of Pma1 ATPase activity and impairs adaptive responses to other facets of polygodial's cellular inhibition.