Miracle-dz/UniFAR-FTUs huggingface dataset:
Distinct genotypic distributions of cytomegalovirus (CMV) envelope glycoprotein in bone marrow and renal transplant recipients with CMV disease

A prospective study of the spectrum of glycoprotein B (gB) and glycoprotein H (gH) genotypes of cytomegalovirus (CMV) was conducted with five categories of patients: viremic bone marrow-transplant (BMT) recipients who developed CMV disease after BMT (n = 22), viremic BMT recipients without CMV disease (n = 11), viremic renal-transplant recipients who developed CMV disease after transplantation (n = 14), viremic renal-transplant recipients without CMV disease (n = 13), and premature babies with asymptomatic congenital CMV infections (n = 13). Genotypic stability was observed because the gB and gH genotypes of multiple isolates obtained from a single patient were identical. The distribution of gH genotypes in patients of all groups studied were similar. However, there was a unique distribution of the gB genotype in the first category of patients, i.e., BMT recipients with CMV disease, which was distinct from those of all other categories (P < 0.05). CMV isolates from 54% of BMT recipients with CMV disease exhibited gB type 2, while isolates from 46, 50, 69, and 77% of the BMT recipients without CMV disease, renal-transplant recipients with and those without CMV disease, and premature babies with congenital CMV infection, respectively, were of gB type 1. An analysis of the clinical characteristics of BMT recipients with CMV disease indicated that all underwent either an allogeneic or matched, unrelated donor transplant, and half had severe acute graft-versus-host disease (grades 2 to 4). The statistically significant genotypic difference between CMV isolates from BMT recipients with and without CMV disease was not observed between isolates from renal-transplant recipients with and without CMV disease. We speculate that differences in pathogenesis in different patient groups might account for these observations. These findings would also facilitate decision making about the choice of recombinant CMV glycoprotein vaccine required to immunize transplant donors and the subsequent adoptive transfer of immunity to BMT recipients. When the source of CMV DNA required for genotyping was investigated among renal-transplant recipients, direct use of peripheral blood leukocytes was 95% effective compared to the effectiveness of cells obtained from conventional culture of peripheral blood specimens.
Foot center of pressure and medial knee osteoarthritis.

BACKGROUND We sought to determine whether symptomatic medial knee osteoarthritis is associated with aberrant loading across the foot during gait. METHODS Twenty-five individuals with medial knee osteoarthritis were compared with 25 controls. Knee radiographs and Western Ontario and McMaster Universities Arthritis Index questionnaires were obtained. Participants walked barefoot over pressure sensors, and the center-of-pressure trace was plotted against the axis of the foot, and a center-of-pressure index was calculated. RESULTS The center-of-pressure indices in the medial knee osteoarthritis group demonstrated high lateral loading compared with the central center-of-pressure pattern in controls (P < .001). There was a correlation between the severity of pain and the center-of-pressure index in patients with medial knee osteoarthritis but no correlation between center of pressure and radiographic severity. CONCLUSIONS The plantar pressure patterns of patients with medial knee osteoarthritis demonstrated greater loading of the lateral aspect of the foot during the contact and midstance phases of gait but not during propulsion compared with those of controls, suggesting that loading patterns in the feet are related to osteoarthritis in the knee.
What about after the covid-19 pandemic? Adolescents’ voices on this period in their lives ¿Qué pasa después de la pandemia de covid-19? adolescentes este período de su vida

secondary education stands out with the report of more negative impacts on mental and social health; secondary education on drinking and reckless driving behaviours; university education on school performance, academic stress, relationships with teachers and classmates; and secondary education on liking school. They identify as most difficult the area of mental health, being away from family and friends, loss of freedom, online classes and loss of social events. Family, friends, technology, exercise, leisure and volunteering were resources for coping with the pandemic. In the consequences on future prospects, although positive, both groups reveal the effects on mental health, and employment issues. In the long term they anticipate problems in the economy, digitalisation at work and a healthier planet. Conclusions: these results are expected to raise awareness of the importance of psychological support, and resource availability during and after the pandemic.
The Structural Stability of the Endothelial Glycocalyx after Enzymatic Removal of Glycosaminoglycans

Rationale It is widely believed that glycosaminoglycans (GAGs) and bound plasma proteins form an interconnected gel-like structure on the surface of endothelial cells (the endothelial glycocalyx layer–EGL) that is stabilized by the interaction of its components. However, the structural organization of GAGs and proteins and the contribution of individual components to the stability of the EGL are largely unknown. Objective To evaluate the hypothesis that the interconnected gel-like glycocalyx would collapse when individual GAG components were almost completely removed by a specific enzyme. Methods and Results Using confocal microscopy, we observed that the coverage and thickness of heparan sulfate (HS), chondroitin sulfate (CS), hyaluronic acid (HA), and adsorbed albumin were similar, and that the thicknesses of individual GAGs were spatially nonuniform. The individual GAGs were degraded by specific enzymes in a dose-dependent manner, and decreased much more in coverage than in thickness. Removal of HS or HA did not result in cleavage or collapse of any of the remaining components. Simultaneous removal of CS and HA by chondroitinase did not affect HS, but did reduce adsorbed albumin, although the effect was not large. Conclusion All GAGs and adsorbed proteins are well inter-mixed within the structure of the EGL, but the GAG components do not interact with one another. The GAG components do provide binding sites for albumin. Our results provide a new view of the organization of the endothelial glycocalyx layer and provide the first demonstration of the interaction between individual GAG components.
Effect of Stad Model of Cooperative Learning on Students’ Learning Outcome on Nomenclature of Hydrocarbon

Students Team Achievement Division model of cooperative learning was employed to examine its effect on the learning outcome of students in the concept of nomenclature of hydrocarbons. Forty-one (41) students were purposively sampled for the study. The study employed an action research design. Pre and post-intervention tests were conducted before and after the intervention respectively to determine the effect of the intervention on students’ learning outcome. The findings from the study showed that the STAD model of cooperative learning significantly improved learning outcome of the students in nomenclature of hydrocarbons. The study concluded that STAD model of cooperative learning was an effective learning model for improving students’ learning outcome. The STAD model of cooperative learning provided conducive environment for active participation of learners resulting in meaning construction of knowledge. The intervention provided opportunities for developing analytical and critical thinking skills. The study therefore recommended the use of STAD model of cooperative learning for students owing to its effectiveness in improving learning outcome.
Do user preferences and evaluation measures line up?

This paper presents results comparing user preference for search engine rankings with measures of effectiveness computed from a test collection. It establishes that preferences and evaluation measures correlate: systems measured as better on a test collection are preferred by users. This correlation is established for both "conventional web retrieval" and for retrieval that emphasizes diverse results. The nDCG measure is found to correlate best with user preferences compared to a selection of other well known measures. Unlike previous studies in this area, this examination involved a large population of users, gathered through crowd sourcing, exposed to a wide range of retrieval systems, test collections and search tasks. Reasons for user preferences were also gathered and analyzed. The work revealed a number of new results, but also showed that there is much scope for future work refining effectiveness measures to better capture user preferences.
Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K+ Channels and p42/p44 MAPK Pathway

Human CYP2J2 is abundant in heart and active in the biosynthesis of epoxyeicosatrienoic acids (EETs); however, the functional role of this P450 and its eicosanoid products in the heart remains unknown. Transgenic mice with cardiomyocyte-specific overexpression of CYP2J2 were generated. CYP2J2 transgenic (Tr) mice have normal heart anatomy and basal contractile function. CYP2J2 Tr hearts have improved recovery of left ventricular developed pressure (LVDP) compared with wild-type (WT) hearts after 20 minutes ischemia and 40 minutes reperfusion. Perfusion with the selective P450 epoxygenase inhibitor N-methylsulphonyl-6-(2-proparglyloxyphenyl)hexanamide (MS-PPOH) for 20 minutes before ischemia results in reduced postischemic LVDP recovery in WT hearts and abolishes the improved postischemic LVDP recovery in CYP2J2 Tr hearts. Perfusion with the ATP-sensitive K+ channel (KATP) inhibitor glibenclamide (GLIB) or the mitochondrial KATP (mitoKATP) inhibitor 5-hydroxydecanoate (5-HD) for 20 minutes before ischemia abolishes the cardioprotective effects of CYP2J2 overexpression. Flavoprotein fluorescence, a marker of mitoKATP activity, is higher in cardiomyocytes from CYP2J2 Tr versus WT mice. Moreover, CYP2J2-derived EETs (1 to 5 &mgr;mol/L) increase flavoprotein fluorescence in WT cardiomyocytes. CYP2J2 Tr mice exhibit increased expression of phospho-p42/p44 mitogen-activated protein kinase (MAPK) after ischemia, and addition of the p42/p44 MAPK kinase (MEK) inhibitor PD98059 during reperfusion abolishes the cardioprotective effects of CYP2J2 overexpression. Together, these data suggest that CYP2J2-derived metabolites are cardioprotective after ischemia, and the mechanism for this cardioprotection involves activation of mitoKATP and p42/p44 MAPK.
Non-uniform robust global asymptotic stability for discrete-time systems and applications to numerical analysis

The notion of non-uniform Robust Global Asymptotic Stability (RGAS) presented in this paper generalizes the notion of non-uniform in time RGAS for finiteor infinite-dimensional discrete-time systems. Lyapunov characterizations for this stability notion are provided. The results are applied to finitedimensional discrete-time systems obtained by time discretization of continuous-time systems by the explicit Euler method.
On the stability of current based MRAS

This paper proposes the design, stability analysis and stabilization methods of current-based MRAS for sensorless vector control of induction motor. For industrial applications, the speed adaptation algorithm has to be stable in wide speed range, in both motoring and regenerating mode of operation. Design of adaptation controller based on linearized model of the observer is included. Theoretical analysis of the stability and two main stabilization methods for stable operation in regenerating mode are described. Finally, experimental results are shown.
Personal Characteristics and Competencies as Correlates of Intercultural Transitional Adjustment Among US and Canadian Sojourners in Ireland

Drawing upon self-report data generated from a postal survey of US and Canadian expatriates in Ireland and following the established argument that expatriate transitional adjustment is best viewed as a multifaceted construct encompassing work, general, interaction, and overall adjustment, we test the extent to which personal characteristics and competencies predict adjustment in these different life domains of international assignees. While gender, marital status, age, and education fail to reach statistical significance, personal competencies show stronger correlations with felt adjustment. Empathy skills, stress reduction skills, and interaction skills were all significantly positively correlated with all the facets of transitional adjustment measured. [PUBLICATION ABSTRACT]
Depth analysis of Midway Atoll using Quickbird multi-spectral imaging over variable substrates

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The Impact of Long-Term Physical Activity Interventions for Overweight/Obese Postmenopausal Women on Adiposity Indicators, Physical Capacity, and Mental Health Outcomes: A Systematic Review

Physical activity interventions have recently become a popular strategy to help postmenopausal women prevent and manage obesity. The current systematic review evaluates the efficacy of physical activity interventions among overweight and obese postmenopausal women and sheds light on the behavioral change techniques that were employed in order to direct future research. Method. Five electronic databases were searched to identify all prospective RCT studies that examine the impact of physical activity on adiposity indicators, physical capacity, and/or mental health outcomes among healthy, sedentary overweight, and obese postmenopausal women in North America. The behavior change technique taxonomy was used to identify the various strategies applied in the programs. Results. Five RCTs met the inclusion criteria. The findings showed that adiposity indicators and physical capacity outcomes significantly improved following long-term interventions; however, mental health outcomes showed nonsignificant changes. Furthermore, 17 behavior change techniques were identified with the taxonomy across all trials. The intrapersonal-level techniques were the most common. Conclusion. Physical activity interventions had a positive effect on adiposity measures and physical capacity. Future research should focus on testing the effectiveness of physical activity interventions on mental health and incorporate strategies at the individual and environmental level to maximize the health impact on the population.
Site‐specific and developmental expression of pannexin1 in the mouse nervous system

Until recently, members of the connexin gene family were believed to comprise the sole molecular component forming gap junction channels in vertebrates. The recent discovery of the pannexin gene family has challenged this view, as these genes may encode for a putative second class of gap junction proteins in vertebrates. The expression of pannexin genes overlaps with those cellular networks known to exhibit a high degree of gap junctional coupling. We investigated the spatio‐temporal mRNA distribution of one member of this gene family, pannexin1 (Panx1), in the brain and retina of mice using quantitative real‐time polymerase chain reaction and a combination of in situ hybridization and immunohistochemistry for cellular resolution. Our results demonstrate a widespread expression of Panx1 in the brain, retina and other non‐neuronal tissues. In the cortex, cerebellum and eye, Panx1 is expressed at early embryonic time points and peaks around embryonic day 18 followed by a decline towards adulthood. Most notably, Panx1 is detectable in neurons of many brain nuclei, which are known to be coupled by gap junctions as well as in previously unrecognized areas. Abundant expression was found in the adult hippocampal and neocortical pyramidal cells and interneurons, neurons of the reticular thalamus, the inferior olive, magnocellular hypothalamic neurons, midbrain and brain stem motoneurons, Purkinje cells and the retina.
System level performance analysis - the SymTA/S approach

SymTA/S is a system-level performance and timing analysis approach based on formal scheduling analysis techniques and symbolic simulation. The tool supports heterogeneous architectures, complex task dependencies and context aware analysis. It determines system-level performance data such as end-to-end latencies, bus and processor utilisation, and worst-case scheduling scenarios. SymTA/S furthermore combines optimisation algorithms with system sensitivity analysis for rapid design space exploration. The paper gives an overview of current research interests in the SymTA/S project.
Model-Independent 3D Descriptors of Vertebral Cancellous Bone Architecture

High-resolution micro computed tomography has enabled measurement of bone architecture derived from 3D representations of cancellous bone. Twenty-eight vertebral bodies were obtained from four embalmed male cadavers. From 3D anaglyphs, trabecular rod thickness and length were measured and the trabecular rod Buckling index was calculated. From 3D voxel-based datasets, bone volume density, trabecular thickness, and trabecular separation were measured. Also, trabecular bone pattern factor, structural model index, connectivity density, and degree of anisotropy were calculated. Bone volume density alone explains 59% of the variability in trabecular rod Buckling index. The addition of connectivity density, trabecular separation, and structural model index, in a multiple regression statistical model, improves the explanatory power to 77%. The relationships between measures of cancellous bone architecture and a derived measure of trabecular rod strength were investigated. Morphological descriptors of cancellous bone provide a composite explanatory model of trabecular rod strength.
Interferon-γ release assays for the diagnosis of active tuberculosis: sensible or silly?

Every time Mycobacterium tuberculosis is recovered from human specimens by microbiological culture, the diagnosis of active tuberculosis (TB) is definite 1. As culture growth of M. tuberculosis may take ≥2 weeks on average, clinicians need to rely on other methods to achieve rapid diagnosis of active TB and justify the decision to treat the patient. The decision to initiate anti-TB treatment can be difficult, especially in children, and is currently based on different criteria including: 1) medical history and local epidemiology; 2) chest radiography; 3) the microscopic detection of acid fast bacilli (AFB); 4) amplification of M. tuberculosis nucleic acids from biological specimens; 5) the detection of mycobacteria-specific immune responses in the tuberculin skin test (TST); and 6) interferon (IFN)-γ release assays (IGRAs). Furthermore, several scoring methods have been proposed to diagnose TB in children when microbiological evidence is lacking. While serological antibody-based tests have not been successful 2, novel methods for the diagnosis of TB are constantly being developed 3. IGRAs, commercially available as the QuantiFERON-TB-Gold® In Tube (QFT-GIT) test (Cellestis, Carnegie, Australia) and as the T-SPOT.TB® test (Oxford Immunotec, Abingdon, UK), are now established in many countries as advanced tools for the immunodiagnosis of latent TB infection (LTBI). In contrast to the mixture of antigens in the purified protein derivate, which is used in the in vivo TST, the IGRA detects effector memory responses to a limited number of specific RD1 peptides by peripheral blood mononuclear cells (PBMC) ex vivo . The genes that encode for the RD1 proteins are absent in the bacille Calmette-Guerin (BCG) vaccine strain. Consequently, in BCG-vaccinated recent contacts of infectious cases, IGRA responses correlate better to M. tuberculosis exposure than the TST 4–8. Therefore, it is plausible that IGRAs are superior to the TST in predicting the development …
Experiencing affective music in eyes-closed and eyes-open states: an electroencephalography study

In real life, listening to music may be associated with an eyes-closed or eyes-open state. The effect of eye state on listeners’ reaction to music has attracted some attention, but its influence on brain activity has not been fully investigated. The present study aimed to evaluate the electroencephalographic (EEG) markers for the emotional valence of music in different eye states. Thirty participants listened to musical excerpts with different emotional content in the eyes-closed and eyes-open states. The results showed that participants rated the music as more pleasant or with more positive valence under an eyes-open state. In addition, we found that the alpha asymmetry indices calculated on the parietal and temporal sites reflected emotion valence in the eyes-closed and eyes-open states, respectively. The theta power in the frontal area significantly increased while listening to emotional-positive music compared to emotional-negative music under the eyes-closed condition. These effects of eye states on EEG markers are discussed in terms of brain mechanisms underlying attention and emotion.
The monogenic signal

This paper introduces a two-dimensional (2-D) generalization of the analytic signal. This novel approach is based on the Riesz transform, which is used instead of the Hilbert transform. The combination of a 2-D signal with the Riesz transformed one yields a sophisticated 2-D analytic signal: the monogenic signal. The approach is derived analytically from irrotational and solenoidal vector fields. Based on local amplitude and local phase, an appropriate local signal representation that preserves the split of identity, i.e., the invariance-equivariance property of signal decomposition, is presented. This is one of the central properties of the one-dimensional (1-D) analytic signal that decomposes a signal into structural and energetic information. We show that further properties of the analytic signal concerning symmetry, energy, allpass transfer function, and orthogonality are also preserved, and we compare this with the behavior of other approaches for a 2-D analytic signal. As a central topic of this paper, a geometric phase interpretation that is based on the relation between the 1-D analytic signal and the 2-D monogenic signal established by the Radon (1986) transform is introduced. Possible applications of this relationship are sketched, and references to other applications of the monogenic signal are given.