Miracle-dz/UniFAR-FTUs huggingface dataset:
Variation in style of magmatism and emplacement mechanism induced by changes in basin environments and stress fields (Pannonian Basin, Central Europe)

The development of high‐resolution 3D seismic cubes has permitted recognition of variable subvolcanic features mostly located in passive continental margins. Our study area is situated in a different tectonic setting, in the extensional Pannonian Basin system (central Europe) where the lithospheric extension was associated with a wide variety of magmatic suites during the Miocene. Our primary objective is to map the buried magmatic bodies, to better understand the temporal and spatial variation in the style of magmatism and emplacement mechanism within the first order Mid‐Hungarian Fault Zone (MHFZ) along which the substantial Miocene displacement took place. The combination of seismic, borehole and log data interpretation enabled us to delineate various previously unknown subvolcanic‐volcanic features. In addition, a new approach of neural network analysis on log data was applied to detect and quantitatively characterise hydrothermal mounds that are hard to interpret solely from seismic data. The volcanic activity started in the Middle Miocene and induced the development of extrusive volcanic mounds south of the NE‐SW trending, continuous strike‐slip fault zone (Hajdú Fault Zone). In the earliest Late Miocene (11.6–9.78 Ma), the style of magmatic activity changed resulting in emplacement of intrusions and development of hydrothermal mounds. Sill emplacement occurred from south‐east to north‐west based on primary flow‐emplacement structures. The time of sill emplacement and the development of hydrothermal mounds can be bracketed by onlapped forced folds and mounds. This time coincided with the acceleration of sedimentation producing poorly consolidated, water‐saturated sediments preventing magma from flowing to the paleosurface. The change in extensional direction resulted in change in fault pattern, thus the formerly continuous basin‐bounding strike‐slip fault became segmented which could facilitate the magma flow toward the basin centre.
The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-γ Inhibitor AS605240 in Autoimmune Diabetes

Type 1 diabetes (T1D) remains a major health problem worldwide, with a steadily rising incidence yet no cure. Phosphoinositide 3-kinase-γ (PI3Kγ), a member of a family of lipid kinases expressed primarily in leukocytes, has been the subject of substantial research for its role in inflammatory diseases. However, the role of PI3Kγ inhibition in suppressing autoimmune T1D remains to be explored. We tested the role of the PI3Kγ inhibitor AS605240 in preventing and reversing diabetes in NOD mice and assessed the mechanisms by which this inhibition abrogates T1D. Our data indicate that the PI3Kγ pathway is highly activated in T1D. In NOD mice, we found upregulated expression of phosphorylated Akt (PAkt) in splenocytes. Notably, T regulatory cells (Tregs) showed significantly lower expression of PAkt compared with effector T cells. Inhibition of the PI3Kγ pathway by AS605240 efficiently suppressed effector T cells and induced Treg expansion through the cAMP response element-binding pathway. AS605240 effectively prevented and reversed autoimmune diabetes in NOD mice and suppressed T-cell activation and the production of inflammatory cytokines by autoreactive T cells in vitro and in vivo. These studies demonstrate the key role of the PI3Kγ pathway in determining the balance of Tregs and autoreactive cells regulating autoimmune diabetes.
Ribosomal Protein L13a Deficiency in Macrophages Promotes Atherosclerosis by Limiting Translation Control-Dependent Retardation of Inflammation

Objective— Unresolved inflammatory response of macrophages plays a pivotal role in the pathogenesis of atherosclerosis. Previously we showed that ribosomal protein L13a-dependent translational silencing suppresses the synthesis of a cohort of inflammatory proteins in monocytes and macrophages. We also found that genetic abrogation of L13a expression in macrophages significantly compromised the resolution of inflammation in a mouse model of lipopolysaccharide-induced endotoxemia. However, its function in the pathogenesis of atherosclerosis is not known. Here, we examine whether L13a in macrophage has a protective role against high-fat diet–induced atherosclerosis. Approach and Results— We bred the macrophage-specific L13a knockout mice L13a Flox+/+ Cre+/+ onto apolipoprotein E–deficient background and generated the experimental double knockout mice L13a Flox+/+ Cre+/+ apolipoprotein E deficient (apoE−/−). L13a Flox+/+ Cre−/− mice on apolipoprotein E–deficient background were used as controls. Control and knockout mice were subjected to high-fat diet for 10 weeks. Evaluation of aortic sinus sections and entire aorta by en face showed significantly higher atherosclerosis in the knockout mice. Severity of atherosclerosis in knockout mice was accompanied by thinning of the smooth muscle cell layer in the media, larger macrophage area in the intimal plaque region and higher plasma levels of inflammatory cytokines. In addition, macrophages isolated from knockout mice had higher polyribosomal abundance of several target mRNAs, thus showing defect in translation control. Conclusions— Our data demonstrate that loss of L13a in macrophages increases susceptibility to atherosclerosis in apolipoprotein E–deficient mice, revealing an important role of L13a-dependent translational control as an endogenous protection mechanism against atherosclerosis.
Optimal Marketing Strategies for a Customer Data Intermediary

Advances in data collection and storage technologies have given rise to the customer data intermediary (CDI), a firm that collects customer data to offer customer-specific marketing services to marketers. With widespread adoption of customer relationship management (CRM) and one-to-one (1:1) marketing, the demand for such services continues to grow. Extant empirical research using customer data for CRM and 1:1 marketing tends to have an engineering emphasis and focuses on developing analysis techniques to implement CRM and 1:1 marketing optimally (i.e., the technology for the CDI). In contrast, this article focuses on marketing strategy issues that the intermediary faces, given the availability of the technology to implement such services. Specifically, the authors develop an empirical framework to evaluate the optimal customer (exclusive/nonexclusive), product (quality or accuracy of the 1:1 customization), and pricing strategy for a CDI. They illustrate the framework for one type of CDI—a 1:1 coupon service firm that caters to grocery manufacturers—using household purchase history data from the ketchup market. The authors find that selling on a nonexclusive basis using the maximum available purchase history data is the most profitable strategy for the CDI in the particular market. They also evaluate the potential impact of retailers entering the 1:1 coupon service business. Because 1:1 marketing can increase the retailer's profits from goods sold, it is optimal for the retailer to undercut the prices of a pure-play CDI that offers 1:1 coupon services.
Dose reduction in paediatric MDCT : general principles

The number of multi-detector array computed tomography (MDCT) examinations performed per annum continues to increase in both the adult and paediatric populations. Estimates from 2003 suggested that CT contributed 17% of a radiology department’s workload, yet was responsible for up to 75% of the collective population dose from medical radiation. The effective doses for some CT examinations today overlap with those argued to have an increased risk of cancer. This is especially pertinent for paediatric CT, as children are more radiosensitive than adults (and girls more radiosensitive than boys). In addition, children have a longer life ahead of them, in which radiation induced cancers may become manifest. Radiologists must be aware of these facts and practise the ALARA (as low as is reasonably achievable) principle, when it comes to deciding CT protocols and parameters. a 2007 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
Financiers Vs. Engineers:Should the Financial Sector Be Taxed or Subsidized?

I study the allocation of human capital in an economy with production externalities, financial constraints and career choices. Agents choose to become entrepreneurs, workers or financiers. Entrepreneurship has positive externalities, but innovators face borrowing constraints and require the services of financiers in order to invest efficiently. When investment and education subsidies are chosen optimally, I find that the financial sector should be taxed in exactly the same way as the non-financial sector. When direct subsidies to investment and scientific education are not feasible, giving a preferred tax treatment to the financial sector can improve welfare by increasing aggregate investment in research and development.
Statistical Evidence Suggests that Inattention Drives Hyperactivity/Impulsivity in Attention Deficit-Hyperactivity Disorder

Background Numerous factor analytic studies consistently support a distinction between two symptom domains of attention-deficit/hyperactivity disorder (ADHD), inattention and hyperactivity/impulsivity. Both dimensions show high internal consistency and moderate to strong correlations with each other. However, it is not clear what drives this strong correlation. The aim of this paper is to address this issue. Method We applied a sophisticated approach for causal discovery on three independent data sets of scores of the two ADHD dimensions in NeuroIMAGE (total N = 675), ADHD-200 (N = 245), and IMpACT (N = 164), assessed by different raters and instruments, and further used information on gender or a genetic risk haplotype. Results In all data sets we found strong statistical evidence for the same pattern: the clear dependence between hyperactivity/impulsivity symptom level and an established genetic factor (either gender or risk haplotype) vanishes when one conditions upon inattention symptom level. Under reasonable assumptions, e.g., that phenotypes do not cause genotypes, a causal model that is consistent with this pattern contains a causal path from inattention to hyperactivity/impulsivity. Conclusions The robust dependency cancellation observed in three different data sets suggests that inattention is a driving factor for hyperactivity/impulsivity. This causal hypothesis can be further validated in intervention studies. Our model suggests that interventions that affect inattention will also have an effect on the level of hyperactivity/impulsivity. On the other hand, interventions that affect hyperactivity/impulsivity would not change the level of inattention. This causal model may explain earlier findings on heritable factors causing ADHD reported in the study of twins with learning difficulties.
Evidence for Fungal Infection in Cerebrospinal Fluid and Brain Tissue from Patients with Amyotrophic Lateral Sclerosis

Among neurogenerative diseases, amyotrophic lateral sclerosis (ALS) is a fatal illness characterized by a progressive motor neuron dysfunction in the motor cortex, brainstem and spinal cord. ALS is the most common form of motor neuron disease; yet, to date, the exact etiology of ALS remains unknown. In the present work, we have explored the possibility of fungal infection in cerebrospinal fluid (CSF) and in brain tissue from ALS patients. Fungal antigens, as well as DNA from several fungi, were detected in CSF from ALS patients. Additionally, examination of brain sections from the frontal cortex of ALS patients revealed the existence of immunopositive fungal antigens comprising punctate bodies in the cytoplasm of some neurons. Fungal DNA was also detected in brain tissue using PCR analysis, uncovering the presence of several fungal species. Finally, proteomic analyses of brain tissue demonstrated the occurrence of several fungal peptides. Collectively, our observations provide compelling evidence of fungal infection in the ALS patients analyzed, suggesting that this infection may play a part in the etiology of the disease or may constitute a risk factor for these patients.
Child seat belt guidelines: Examining the 4 feet 9 inches rule as the standard.

BACKGROUND Current American Academy of Pediatrics recommendations regarding transition from child safety/booster seat to adult safety belt use indicate that children should be at least 4 feet 9 inches, 8 years old, or 80 pounds. Proper fit in the vehicle seat, assessed with a five-point fit test, should also be met. Although most children reach 4 feet 9 inches around age 8 years, each child and vehicle presents a unique combination; thus a child may not fit appropriately in all vehicle types using only the 4 feet 9 inches requirement. METHODS We enrolled children, aged 7 years to 12 years, into our study. Height, weight, and demographic data were obtained. A Child Passenger Safety Technician then performed the five-point fit test in each of a uniform lineup of five vehicles. Data were collected on fit in the standard vehicle seat and also in a booster seat. We set 90% as the threshold proportion of children who meet all criteria for proper fit to validate current recommendations of a height of 4 feet 9 inches. RESULTS Data were collected on 388 children. The percentage of 90% proper fit was met in the compact car and small sport-utility vehicle (SUV). However, only 80 (77%) of 104 students (p < 0.0001) that were 4 feet 9 inches or higher fit properly in the large SUV, only 87 (83%) of 105 students (p = 0.02) fit properly in the pickup truck, and only 91 (89%) of 102 students (p = 0.74) fit properly in the minivan. CONCLUSION Substantial proportions of children meeting current height guidelines for an adult seat belt do not meet safety requirements for fit, especially in larger, commonly used vehicles (large SUVs and trucks). This emphasizes the need for evaluation of fit by a trained personnel and/or development of standard back seat dimensions in all vehicles for maximum safety. LEVEL OF EVIDENCE Epidemiologic level 1.
Major contribution of neutral clusters to new particle formation at the interface between the boundary layer and the free troposphere

Abstract. The formation of new aerosol particles in the atmosphere is a key process influencing the aerosol number concentration as well as the climate, in particular at high altitude, where the newly formed particles directly influence cloud formation. However, free tropospheric new particle formation (NPF) is poorly documented due to logistic limitations and complex atmospheric dynamics around high-altitude stations that make the observation of this day-time process challenging. Recent improvements in measurement techniques make now possible the detection of neutral clusters down to ~ 1 nm sizes, which opens new horizons in our understanding of the nucleation process. Indeed, only the charged fraction of clusters has been reported in the upper troposphere up to now. Here we report day-time concentrations of charged and neutral clusters (1 to 2.5 nm mobility diameter) recorded at the interface between the boundary layer (BL) and the FT as well as in the FT at the altitude site of Puy de Dome (1465 m a.s.l.), central France, between 10 and 29 February 2012. Our findings demonstrate that in the FT, and especially at the interface between the BL and the FT, the formation of 1.5 nm neutral clusters significantly exceeds the one of ionic clusters during NPF events, clearly indicating that they dominate in the nucleation process. We also observe that the total cluster concentration significantly increases during NPF events compared to the other days, which was not clearly observed for the charged cluster population in the past. During the studied period, the nucleation process does not seem to be sulfuric acid-limited and could be promoted by the transport of pollutants to the upper troposphere, coupled with low temperatures.
Improving Word Sense Disambiguation in Neural Machine Translation with Sense Embeddings

Word sense disambiguation is necessary in translation because different word senses often have different translations. Neural machine translation models learn different senses of words as part of an end-to-end translation task, and their capability to perform word sense disambiguation has so far not been quantified. We exploit the fact that neural translation models can score arbitrary translations to design a novel cross-lingual word sense disambiguation task that is tailored towards evaluating neural machine translation models. We present a test set of 7,200 lexical ambiguities for German → English, and 6,700 for German → French, and report baseline results. With 70% of lexical ambiguities correctly disambiguated, we find that word sense disambiguation remains a challenging problem for neural machine translation, especially for rare word senses. To improve word sense disambiguation in neural machine translation, we experiment with two methods to integrate sense embeddings. In a first approach we pass sense embeddings as additional input to the neural machine translation system. For the second experiment, we extract lexical chains based on sense embeddings from the document and integrate this information into the NMT model. While a baseline NMT system disambiguates frequent word senses quite reliably, the annotation with both sense labels and lexical chains improves the neural models’ performance on rare word senses.
Life or death decisions in the corpus luteum.

The corpus luteum (CL) is an ephemeral endocrine organ. During its lifespan, it undergoes a period of extremely rapid growth that involves hypertrophy, proliferation and differentiation of the steroidogenic cells, as well as extensive angiogenesis. The growth phase is followed by a period in which remodelling of the tissue ceases, but it engages in unparalleled production of steroids, resulting in extraordinarily high metabolic activity within the tissue. It is during this stage that a critical juncture occurs. In the non-fertile cycle, uterine release of prostaglandin (PG)F(2α) initiates a cascade of events that result in rapid loss of steroidogenesis and destruction of the luteal tissue. Alternatively, if a viable embryo is present, signals are produced that result in rescue of the CL. This review article summarizes the major concepts related to the fate of the CL, with particular focus on recent insights into the mechanisms associated with the ability of PGF(2α) to bring about complete luteolysis. It has become clear that the achievement of luteolysis depends on repeated exposure to PGF(2α) and involves coordinated actions of heterogeneous cell types within the CL. Together, these components of the process bring about not only the loss in progesterone production, but also the rapid demise of the structure itself.
A Type 2C Protein Phosphatase FgPtc3 Is Involved in Cell Wall Integrity, Lipid Metabolism, and Virulence in Fusarium graminearum

Type 2C protein phosphatases (PP2Cs) play important roles in regulating many biological processes in eukaryotes. Currently, little is known about functions of PP2Cs in filamentous fungi. The causal agent of wheat head blight, Fusarium graminearum, contains seven putative PP2C genes, FgPTC1, -3, -5, -5R, -6, -7 and -7R. In order to investigate roles of these PP2Cs, we constructed deletion mutants for all seven PP2C genes in this study. The FgPTC3 deletion mutant (ΔFgPtc3-8) exhibited reduced aerial hyphae formation and deoxynivalenol (DON) production, but increased production of conidia. The mutant showed increased resistance to osmotic stress and cell wall-damaging agents on potato dextrose agar plates. Pathogencity assays showed that ΔFgPtc3-8 is unable to infect flowering wheat head. All of the defects were restored when ΔFgPtc3-8 was complemented with the wild-type FgPTC3 gene. Additionally, the FgPTC3 partially rescued growth defect of a yeast PTC1 deletion mutant under various stress conditions. Ultrastructural and histochemical analyses showed that conidia of ΔFgPtc3-8 contained an unusually high number of large lipid droplets. Furthermore, the mutant accumulated a higher basal level of glycerol than the wild-type progenitor. Quantitative real-time PCR assays showed that basal expression of FgOS2, FgSLT2 and FgMKK1 in the mutant was significantly higher than that in the wild-type strain. Serial analysis of gene expression in ΔFgPtc3-8 revealed that FgPTC3 is associated with various metabolic pathways. In contrast to the FgPTC3 mutant, the deletion mutants of FgPTC1, FgPTC5, FgPTC5R, FgPTC6, FgPTC7 or FgPTC7R did not show aberrant phenotypic features when grown on PDA medium or inoculated on wheat head. These results indicate FgPtc3 is the key PP2C that plays a critical role in a variety of cellular and biological functions, including cell wall integrity, lipid and secondary metabolisms, and virulence in F. graminearum.
Comparative Genomics Reveals Key Gain-of-Function Events in Foxp3 during Regulatory T Cell Evolution

The immune system has the ability to suppress undesirable responses, such as those against commensal bacteria, food, and paternal antigens in placenta pregnancy. The lineage-specific transcription factor Foxp3 orchestrates the development and function of regulatory T cells underlying this immunological tolerance. Despite the crucial role of Foxp3 in supporting immune homeostasis, little is known about its origin, evolution, and species conservation. We explore these questions using comparative genomics, structural modeling, and functional analyses. Our data reveal that key gain-of-function events occurred during the evolution of Foxp3 in higher vertebrates. We identify key conserved residues in its forkhead domain and show a detailed analysis of the N-terminal region of Foxp3, which is only conserved in mammals. These components are under purifying selection, and our mutational analyses demonstrate that they are essential for Foxp3 function. Our study points to critical functional adaptations in immune tolerance among higher vertebrates, and suggests that Foxp3-mediated transcriptional mechanisms emerged during mammalian evolution as a stepwise gain of functional domains that enabled Foxp3 to interact with a multitude of interaction partners.
A call admission control scheme for heterogeneous service considering fairness in wireless networks

Guaranteeing a handoff dropping probability below a predetermined threshold is essential for wireless mobile networks. Previous researches have proposed admission control policies for integrated voice/data traffic in wireless mobile networks. However, since QoS has been considered only in terms of CDP (call dropping probability), the result has been a serious CBP (Call Blocking Probability) unfairness problem between voice and data traffic. In this paper, we suggest a new admission control policy that treats integrated voice and data traffic fairly while maintaining the CDP constraint. For underprivileged data traffic, which requires more bandwidth units than voice traffic, the packet is placed in a queue when there are no available resources in the base station, instead of being immediately rejected. Furthermore, we have adapted the biased coin method concept to adjust unfairness in terms of CBP. We analyzed the system model of a cell using both a two-dimensional continuous-time Markov chain and the Gauss-Seidel method. Numerical results demonstrate that our CAC (call admission control) scheme successfully achieves CBP fairness for voice and data traffic.
Lessons from LAMS for IMS Learning Design

LAMS (the learning activity management system) is a learning design system with a particular focus on sequencing of collaborative learning activities. This paper reviews a number of lessons learned from the development of LAMS, and their implications for both the existing IMS learning design specification, and its future scope and purpose. It proposes a number of areas for further development