Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy

The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the ribosomal function. The discovery of the RIPs was almost a century ago, but their usage has seen transition only in the last four decades. With the advent of antibody therapy, the RIPs have been a subject of extensive research especially in targeted tumor therapies, which is the primary focus of this review. In the present work we enumerate 250 RIPs, which have been identified so far. An attempt has been made to identify all the RIPs that have been used for the construction of immunotoxins, which are conjugates or fusion proteins of an antibody or ligand with a toxin. The data from 1960 onwards is reviewed in this paper and an extensive list of more than 450 immunotoxins is reported. The clinical reach of tumor-targeted toxins has been identified and detailed in the work as well. While there is a lot of potential that RIPs embrace for targeted tumor therapies, the success in preclinical and clinical evaluations has been limited mainly because of their inability to escape the endo/lysosomal degradation. Various strategies that can increase the efficacy and lower the required dose for targeted toxins have been compiled in this article. It is plausible that with the advancements in platform technologies or improved endosomal escape the usage of tumor targeted RIPs would see the daylight of clinical success.
Priming the Primal Scene: Betrayal Trauma, Narcissism, and Attitudes Toward Sexual Infidelity

We used mindset priming techniques to conduct an experimental study (N = 316) designed to assess ideas derived from psychoanalytic theory. Specifically, we investigated the possibility that the unconscious activation of the Oedipal situation would lead people—especially men and individuals who possess narcissistic personality features—to become more prohibitive toward sexual infidelity in romantic relationships. Results supported this hypothesis, which was tested using a new scale of attitudes toward sexual infidelity. Although men and narcissists tend to be more permissive towards sexual infidelity in general, when they are led to identify and empathize with the victim of betrayal, they become as disapproving of extra-dyadic sexual involvement as are women and low narcissists. Correlational evidence indicates that narcissism is positively associated with the likelihood of having affairs, the number of partners cheated on, and (for women but not men) the likelihood of being cheated on. In addition, the (self-reported) occurrence of parental cheating behavior is positively associated with one's eventual likelihood of cheating on others. Among daughters (but not sons), a history of parental cheating is associated with increased narcissism and the likelihood of being cheated on. Potential explanations and clinical implications of our findings are discussed.
Linear perturbations of quaternionic metrics. II. The quaternionic-Kahler case

We extend the twistor methods developed in our earlier work on linear deformations of hyperkähler manifolds [1] to the case of quaternionic-Kähler manifolds. Via Swann’s construction, deformations of a 4d-dimensional quaternionic-Kähler manifold M are in one-to-one correspondence with deformations of its 4d+ 4-dimensional hyperkähler cone S. The latter can be encoded in variations of the complex symplectomorphisms which relate different locally flat patches of the twistor space ZS , with a suitable homogeneity condition that ensures that the hyperkähler cone property is preserved. Equivalently, we show that the deformations of M can be encoded in variations of the complex contact transformations which relate different locally flat patches of the twistor space ZM of M, by-passing the Swann bundle and its twistor space. We specialize these general results to the case of quaternionic-Kähler metrics with d + 1 commuting isometries, obtainable by the Legendre transform method, and linear deformations thereof. We illustrate our methods for the hypermultiplet moduli space in string theory compactifications at treeand one-loop level.
β-Adrenergic Blockade during Memory Retrieval in Humans Evokes a Sustained Reduction of Declarative Emotional Memory Enhancement

Memory enhancement for emotional events is dependent on amygdala activation and noradrenergic modulation during learning. A potential role for noradrenaline (NE) during retrieval of emotional memory is less well understood. Here, we report that administration of the β-adrenergic receptor antagonist propranolol at retrieval abolishes a declarative memory enhancement for emotional items. Critically, this effect persists at a subsequent 24 h memory test, in the absence of propranolol. Thus, these findings extend our current understanding of the role of NE in emotional memory to encompass effects at retrieval, and provide face validity to clinical interventions using β-adrenergic antagonists in conjunction with reactivation of unwanted memories in anxiety-related disorders.
To Work or Not to Work… in a Multicultural Team?

Abstract The main goal of the article is to present research findings regarding student’s attitude to working in a multicultural team (MCT). Research participants of different cultural background completed the research survey. Their willingness to work in MCT was measured together with factors that influence it. These include factors related to both team members and the task structure. Research findings indicate that the respondents preferred to work in MCT if the task required diversity of cognitive perspectives, e.g. in a situation requiring creative or out-of-the-box thinking. In contrast, the strongest preference for working in a single-culture team (SCT) was present in the case of tasks requiring mutual understanding among the team members and like-mindedness. In addition, it was found that the preference to work in SCT or MCT entrusted with a task with specific requirements was also related to the experience in working in such teams declared by the respondents. Conclusions and recommendations may be utilized to design methods for managerial education and training.
Is Unilateral Vocal Fold Paralysis a Rare Complication of Spinal Anesthesia? ACase Report

A 47 year old woman underwent an open reduction and internal fixation of a left ankle fracture under spinal anesthesia. In the recovery room, she noticed a sudden onset of dysphonia. Fiberoptic examination revealed an immobile right vocal fold. Her symptoms gradually improved over the next few weeks with conservative treatment. By the eighth week, her voice had returned to normal. Anesthesiologists should be aware that dysphonia that develops immediately or shortly after spinal anesthesia may represent a unilateral vocal fold paralysis (VFP).
The Thermal Evolution of the Grenville Terrane Revealed through U‐Pb and Fission‐Track Analysis of Detrital Zircon from Cambro‐Ordovician Quartz Arenites of the Potsdam and Galway Formations

Tectonothermal studies of Precambrian terranes using detrital zircons have been the domain of U‐Pb dating techniques. Advancements in technology have made it possible to study the low‐temperature evolution of these terranes with the fission‐track (FT) dating method, and combining these two techniques provides a unique look at the thermal evolution of Precambrian terranes. Detrital zircon grains from the upper middle Cambrian to lower middle Cambrian Potsdam and Galway formations in New York State, which uncomformably overlie the Precambrian Grenville terrane, were analyzed by U‐Pb and FT dating. Approximately 90% of the U‐Pb ages fall between 950 and 1200 Ma, fully consistent with the idea that these zircons are derived almost entirely from Grenville‐age rock. Zircon FT (ZFT) ages from the same suite of samples have component populations of ∼540, ∼780, and ∼1200 Ma, with single‐grain ages as old as 2.1 Ga. The most important observations from the FT data are that there is no widespread resetting on either side of the Adirondacks, that the component populations are older than the age of deposition, and therefore that the principle population likely reflects the cooling ages of what was almost exclusively Grenville source rock. The ZFT component populations older than Grenville tectonic events (FT age > 1.6 Ga) suggest that these old grains and the zircon with old U‐Pb ages were transported from other nearby Precambrian terranes, such as the Superior and the Yavapai‐Mazatzal. These FT data show that the Potsdam and Galway formations have not undergone heating significant enough to reset fission tracks in zircon since deposition and that the heating in the source rocks at 540 Ma corresponds to cooling after the breakup of Rodinia and the rifting of the Iapetus Ocean.
Robust statistics for outlier detection

When analyzing data, outlying observations cause problems because they may strongly influence the result. Robust statistics aims at detecting the outliers by searching for the model fitted by the majority of the data. We present an overview of several robust methods and outlier detection tools. We discuss robust procedures for univariate, low‐dimensional, and high‐dimensional data such as estimation of location and scatter, linear regression, principal component analysis, and classification. © 2011 John Wiley & Sons, Inc. WIREs Data Mining Knowl Discov 2011 1 73‐79 DOI: 10.1002/widm.2
Effects of News Frames on Perceived Risk, Emotions, and Learning

The media play a key role in forming opinions by influencing people´s understanding and perception of a topic. People gather information about topics of interest from the internet and print media, which employ various news frames to attract attention. One example of a common news frame is the human-interest frame, which emotionalizes and dramatizes information and often accentuates individual affectedness. Our study investigated effects of human-interest frames compared to a neutral-text condition with respect to perceived risk, emotions, and knowledge acquisition, and tested whether these effects can be "generalized" to common variants of the human-interest frame. Ninety-one participants read either one variant of the human-interest frame or a neutrally formulated version of a newspaper article describing the effects of invasive species in general and the Asian ladybug (an invasive species) in particular. The framing was achieved by varying the opening and concluding paragraphs (about invasive species), as well as the headline. The core text (about the Asian ladybug) was the same across all conditions. All outcome variables on framing effects referred to this common core text. We found that all versions of the human-interest frame increased perceived risk and the strength of negative emotions compared to the neutral text. Furthermore, participants in the human-interest frame condition displayed better (quantitative) learning outcomes but also biased knowledge, highlighting a potential dilemma: Human-interest frames may increase learning, but they also lead to a rather unbalanced view of the given topic on a “deeper level”.
Exact Multiplicity of Solutions and S-shaped Bifurcation Curve for a Class of Semi-linear Elliptic Equations from a Chemical Reaction Model

Bifurcation Theory is gradually becoming a valuable branch of mathematics in recent three or four decades. Its theories and applications are represented in lots of subjects, e.g. Biological Mathematics, Economy Mathematics, Management Mathematics, and so on. Generally speaking, bifurcation diagram serves as a very important role in Bifurcation Theory. However, the diversity of nonlinearity f decides the various forms of the corresponding bifurcation diagram, so do the researching tools on the problem. In this paper, we get an exact multiplicity of positive solutions and the explicit bifurcation diagram on a class of semi-linear elliptic equation. In Chapter 1, introductions about several kinds of semi-linear elliptic equations and their recent results. From an autocatalyic chemical reaction in Chapter 2, we established a mathematical model. Furthermore, we propose the problem of positive solutions on the equation 
The predictive Value of Total Neutrophil Count and Neutrophil/Lymphocyte Ratio in Predicting In-hospital Mortality and Complications after STEMI

Introduction: Leukocytosis, predominantly neutrophilia, has previously been described following ST elevation myocardial infarction (STEMI). The exact contribution of this phenomenon to the clinical outcome of STEMI is yet to be shown. We examined cellular inflammatory response to STEMI in the blood and its association with in-hospital mortality and/or adverse clinical events. Methods: In this cross-sectional study, 404 patients who were admitted with the diagnosis of acute STEMI at Madani Heart Hospital from March 2010 to March 2012 were studied. The complete blood cell count (CBC) was obtained from all patientswithin12-24 hours of the onset of symptoms. Total leukocytes were counted and differential count was obtained for neutrophils, lymphocytes and neutrophil/lymphocyte ratio (NLR) were evaluated. Association of cellular response with the incidence of post-MI mortality/complications was assessed by multiple logistic regression analyses. Results: In-hospital mortality and post-STEMI complication rate were 3.7% and 43.6%, respectively. Higher age (P=0.04), female gender (0.002), lower ejection fraction (P<0.001) and absolute neutrophil count (P=0.04) were predictors of mortality. Pump failure in the form of acute pulmonary edema or cardiogenic shock occurred in 35 (8.9%) of patients. Higher leukocyte (P<0.03) and neutrophil counts (P<0.03) and higher NLR (P=0.01) were predictors of failure. The frequency of ventricular tachyarrhythmias (VT/VF) at the first day was associated with higher neutrophil count (P<0.001) and higher NLR level (P<0.001). In multivariate analysis neutrophil count was an independent predictor of mortality (OR=2.94; 1.1-8.4, P=0.04), and neutrophil count [OR=1.1, CI (1.01-1.20), P=0.02], female gender [OR=2.34, CI (1.02-4.88), P=0.04] and diabetes [OR=2.52, CI (1.21-5.2), P=0.003] were independent predictors of heart failure. Conclusion: A single CBC analysis may help to identify STEMI patients at risk for mortality and heart failure, and total neutrophil count is the most valuable in predicting both.
Efficacy of low-frequency low-intensity electrotherapy in the treatment of breast cancer-related lymphoedema: a cross-over randomized trial

Objective: To compare the efficacy of low-frequency low-intensity electrotherapy and manual lymphatic drainage in the treatment of chronic upper limb breast cancer-related lymphoedema. Design: Cross-over single-blind random clinical trial. Setting: Rehabilitation service. Participants: Thirty-six women with chronic upper limb breast cancer-related lymphoedema. Methods: Patients were randomized to undergo 10 sessions of manual lymphatic drainage followed by 10 sessions of low-frequency low-intensity electrotherapy or to undergo first low-frequency low-intensity electrotherapy followed by manual lymphatic drainage. There was a month of washout time between treatments. Each patient was examined just before and after each treatment. Researchers and outcome assessors were blinded for assigned treatment. Measures: Outcomes were lymphoedema volume, pain, heaviness and tightness, and health-related quality of life measured with the Functional Assessment of Cancer Therapy Questionnaire for Breast Cancer version 4 (FACT-B+4). Carry-over, period and treatment effects were analysed. Treatment effect was assessed using paired t-test. Results: Thirty patients finalized treatment. Comparing the changes in low-frequency low-intensity electrotherapy with manual lymphatic drainage changes, there were no significant differences. Low-frequency low-intensity electrotherapy did not reduce lymphoedema volume (mean of change = 19.77 mL, P = 0.36), but significant reductions were observed in pain, heaviness and tightness (mean of change = 13.1, 16.2 and 6.4 mm, respectively), and FACT-B+4 summaries improved significantly (Trial Outcome Index mean of change = 5.4, P = 0.015). Manual lymphatic drainage showed no significant changes in any of the outcomes Conclusion: Although there are no significant differences between treatment changes, the observed trend towards a better health-related quality of life is remarkable in low-frequency low-intensity electrotherapy.
Effect of a one-week spiritual retreat on dopamine and serotonin transporter binding: a preliminary study

ABSTRACT Spiritual retreats are a commonly used intensive program of meditation and prayer, along with other elements, designed to provide participants with opportunities for spiritual and psychological growth. While individual elements of such retreats have been studied, there have been no reports in the literature regarding the neurophysiological effects of these retreats. This preliminary study presents the first data we are aware of on the neurophysiological effects, particularly those related to dopamine and serotonin, in a group of participants undergoing an intensive seven-day spiritual retreat. We used DaTscan single photon emission computed tomography (SPECT) in 14 individuals before and closely following participation in a seven-day spiritual retreat. We observed significant decreases in dopamine transporter binding in the basal ganglia and significant decreases in serotonin transporter binding in the midbrain after the retreat program. Participating in the retreat also resulted in significant changes in a variety of psychological and spiritual measures. We also report the relationship between neurophysiological and subjective measures along with a discussion of potential methodological challenges for future studies.
Small-world networks, absorptive capacity and firm performance: evidence from the US venture capital industry

A small-world network is a locally clustered network with short path lengths connecting different clusters. In this study, we explore contingent factors that affect the impact of small-world networks on firm performance, maintaining that benefits from such networks may depend on a firm’s absorptive capacity to recognise and assimilate external information and knowledge. Using a sample of US Venture Capital (VC) firms from 1995 to 2003, we find that small-world networks have a positive impact on firm performance and this positive impact varies with multiple determinants of a firm’s absorptive capacity. Implications of these findings for organisational learning and interfirm network studies are discussed.
Using Auditory Word Repetition to Improve L2 Pronunciation of English Schwa by Japanese Learners: From the Perspective of Phonological Processing

This study investigates the effects of immediate repetition of auditory words on L2 pronunciation improvement of English schwa by Japanese EFL learners. More specifically, the study is concerned with how the amount of input (i.e., five or ten repetitions) and stimuli characteristics (i.e., the position of schwa in a word, word familiarity) influences the repetition effect. The study consists of a study and a test phase: In the study phase, participants listened to and repeated words. In the test phase, they repeated spoken stimuli including previously heard as well as new words, both ten minutes and one week after the study phase. The auditory materials consisted of 32 real words. The duration ratio of schwa to a stressed vowel in a word and the quality of the schwa were acoustically examined. A repetition effect was mainly found in the durational aspect. Repeating the stimuli more than five times did not differentiate the effect. One week after the study phase, the effect persisted only for initial schwa, which is weakly represented in the participants’ mental representation. The pedagogical implications for L2 pronunciation teaching from the view of language processing are discussed.
Pre-anesthetic echocardiographic findings in children undergoing non-cardiac surgery at the University of Benin Teaching Hospital, Nigeria

Summary Background A pre-anaesthestic echocardiogram (echo) is requested for most non-cardiac surgeries to identify possible cardiac structural anomalies Objective To describe the prevalence and spectrum of structural cardiac abnormalities seen in various non-cardiac conditions Methods We carried out a retrospective review of pre-anaesthetic echos performed over five years on children scheduled for non-cardiac surgery. The requests were categorised according to referring specialities, and the biodata and echo findings were noted Results A total of 181 children and 181 echocardiograms were studied, and 100 (55.2%) of the patients were male. Most of the children (87, 48.1%) with oro-facial clefts were referred from dentistry. Of the 181 children, 39 (21.5%) had cardiac abnormalities, most (34, 87.2%) of whom had congenital heart disease (CHD). Ophthalmic requests with suspected congenital rubella syndrome (CRS) had the highest prevalence of 8/12 (66.7%) while the lowest was oro-facial clefts at 15/87 (17.2%). Atrial septal defect was the commonest abnormality, found in 14 patients (35.9%) Conclusion Pre-anaesthetic echo should be performed, especially for children with suspected CRS and other congenital anomalies, requiring non-cardiac surgery.
Exercise Training Prevents Oxidative Stress and Ubiquitin-Proteasome System Overactivity and Reverse Skeletal Muscle Atrophy in Heart Failure

Background Heart failure (HF) is known to lead to skeletal muscle atrophy and dysfunction. However, intracellular mechanisms underlying HF-induced myopathy are not fully understood. We hypothesized that HF would increase oxidative stress and ubiquitin-proteasome system (UPS) activation in skeletal muscle of sympathetic hyperactivity mouse model. We also tested the hypothesis that aerobic exercise training (AET) would reestablish UPS activation in mice and human HF. Methods/Principal Findings Time-course evaluation of plantaris muscle cross-sectional area, lipid hydroperoxidation, protein carbonylation and chymotrypsin-like proteasome activity was performed in a mouse model of sympathetic hyperactivity-induced HF. At the 7th month of age, HF mice displayed skeletal muscle atrophy, increased oxidative stress and UPS overactivation. Moderate-intensity AET restored lipid hydroperoxides and carbonylated protein levels paralleled by reduced E3 ligases mRNA levels, and reestablished chymotrypsin-like proteasome activity and plantaris trophicity. In human HF (patients randomized to sedentary or moderate-intensity AET protocol), skeletal muscle chymotrypsin-like proteasome activity was also increased and AET restored it to healthy control subjects’ levels. Conclusions Collectively, our data provide evidence that AET effectively counteracts redox imbalance and UPS overactivation, preventing skeletal myopathy and exercise intolerance in sympathetic hyperactivity-induced HF in mice. Of particular interest, AET attenuates skeletal muscle proteasome activity paralleled by improved aerobic capacity in HF patients, which is not achieved by drug treatment itself. Altogether these findings strengthen the clinical relevance of AET in the treatment of HF.
Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

ABSTRACT We report here a comparative study of the anti-hepatitis C virus (HCV) activities of selected (i) nucleoside polymerase, (ii) nonnucleoside polymerase, (iii) α,γ-diketo acid polymerase, (iv) NS3 protease, and (v) helicase inhibitors, as well as (vi) cyclophilin binding molecules and (vii) alpha 2b interferon in four different HCV genotype 1b replicon systems.