Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of plastic strain on magnetic behaviour of non-oriented Fe-3Si and application to manufacturing test by punching

AbstractThe prediction of core losses in a rotating electrical machine generally requires a numerical approach (finite element or integral method). However, the magnetic characteristics obtained through a standard Epstein facility and inserted in the numerical models predict losses which are quite different from those obtained experimentally. This difference can be partly explained by the presence of plastic strain close to the cutting edge of manufactured motor sheets. In the present paper, numerical functions are first established to predict the change in the magnetisation and loss curves with respect to the plastic strain level. Second, a microhardness test is used to measure the local plastic strain directly on the manufactured sheet. Finally, relations are obtained between the main magnetic properties and the position on the sheet: the resulting magnetic property profiles allow the numerical approach to be improved.MST/2039
Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration*

Stimulation of T cells leads to distinct changes of their adhesive and migratory properties. Signal propagation from activated receptors to integrins depends on scaffolding proteins such as the adhesion and degranulation promoting adaptor protein (ADAP)1. Here we have comprehensively investigated the phosphotyrosine interactome of ADAP in T cells and define known and novel interaction partners of functional relevance. While most phosphosites reside in unstructured regions of the protein, thereby defining classical SH2 domain interaction sites for master regulators of T cell signaling such as SLP76, Fyn-kinase, and NCK, other binding events depend on structural context. Interaction proteomics using different ADAP constructs comprising most of the known phosphotyrosine motifs as well as the structured domains confirm that a distinct set of proteins is attracted by pY571 of ADAP, including the ζ-chain-associated protein kinase of 70 kDa (ZAP70). The interaction of ADAP and ZAP70 is inducible upon stimulation either of the T cell receptor (TCR) or by chemokine. NMR spectroscopy reveals that the N-terminal SH2 domains within a ZAP70-tandem-SH2 construct is the major site of interaction with phosphorylated ADAP-hSH3N and microscale thermophoresis (MST) indicates an intermediate binding affinity (Kd = 2.3 μm). Interestingly, although T cell receptor dependent events such as T cell/antigen presenting cell (APC) conjugate formation and adhesion are not affected by mutation of Y571, migration of T cells along a chemokine gradient is compromised. Thus, although most phospho-sites in ADAP are linked to T cell receptor related functions we have identified a unique phosphotyrosine that is solely required for chemokine induced T cell behavior.
A Middleware Approach to Causal Order Delivery in Distributed Simulations

This paper describes a middleware approach to the implementation of a time management mechanism based on Causal Order (CO) delivery. CO ensures that messages are delivered to the local federate according to the cause and effect relationship of the events in those messages. The middleware, which encapsulates the CO delivery algorithm, provides exactly the same interface as that defined by the HLA Interface Specification. Experimental results on applications with varying degrees of coupling show that the CO delivery algorithm incurs only a small overhead compared to the Receive Order (RO) mechanism, but achieves a significant performance improvement over the Time Stamp Order (TSO) mechanism. Thus, the CO mechanism can be used in situations where we wish to guarantee the cause and effect relationship between events and also meet the real-time requirements of the simulation. The results also show that the performance of the middleware approach is close to that of an embedded implementation.
StreamBox: Modern Stream Processing on a Multicore Machine

Stream analytics on real-time events has an insatiable demand for throughput and latency. Its performance on a single machine is central to meeting this demand, even in a distributed system. This paper presents a novel stream processing engine called StreamBox that exploits the parallelism and memory hierarchy of modern multicore hardware. StreamBox executes a pipeline of transforms over records that may arrive out-of-order. As records arrive, it groups the records into ordered epochs delineated by watermarks. A watermark guarantees no subsequent record’s event timestamp will precede it. Our contribution is to produce and manage abundant parallelism by generalizing out-of-order record processing within each epoch to out-of-order epoch processing and by dynamically prioritizing epochs to optimize latency. We introduce a data structure called cascading containers, which dynamically manages concurrency and dependences among epochs in the transform pipeline. StreamBox creates sequential memory layout of records in epochs and steers them to optimize NUMA locality. On a 56-core machine, StreamBox processes records up to 38 GB/sec (38M Records/sec) with 50 ms latency.
Prioritizing tests for fault localization through ambiguity group reduction

In practically all development processes, regression tests are used to detect the presence of faults after a modification. If faults are detected, a fault localization algorithm can be used to reduce the manual inspection cost. However, while using test case prioritization to enhance the rate of fault detection of the test suite (e.g., statement coverage), the diagnostic information gain per test is not optimal, which results in needless inspection cost during diagnosis. We present RAPTOR, a test prioritization algorithm for fault localization, based on reducing the similarity between statement execution patterns as the testing progresses. Unlike previous diagnostic prioritization algorithms, RAPTOR does not require false negative information, and is much less complex. Experimental results from the Software Infrastructure Repository's benchmarks show that RAPTOR is the best technique under realistic conditions, with average cost reductions of 40% with respect to the next best technique, with negligible impact on fault detection capability.
Concurrent and Long-Term Impact of Intimate Partner Violence on Employment Stability

Previous research suggests that experiencing intimate partner violence (IPV) may negatively affect employment outcomes. This study explores the relationship between IPV and employment stability both concurrently and longitudinally among a sample of 512 predominantly Asian American and Pacific Islander young women living in Hawaii. Women in this study were identified as being at risk of child maltreatment. About half of women indicated that their current relationship status was married or living together. More than two-thirds of women had graduated from high school and half had worked in the past year. The study explored the concurrent association of IPV and employment by assessing them simultaneously over a 12 month time period. The study examined the longitudinal impact of IPV by analyzing violence at two time points as predictors of unstable employment 6 to 8 years later. The study also explored the mediating effects of depression. Study results demonstrated both concurrent and longitudinal negative associations of IPV with employment stability. Women who experienced violence were more likely to be experiencing unstable employment concurrently. Women who experienced IPV at one point in time had lower levels of employment stability six years later. This decrease was partially mediated by experiencing depressive symptoms. Women who identified their primary ethnicity as Native Hawaiian or Pacific Islander were much more likely to experience unstable employment than Asian American women. More research is needed to explore the roles of mental health, race and ethnicity, and types of violence in the relationship between IPV and employment.
TOTAL KNEE ARTHROPLASTY IN JUVENILE RHEUMATOID

The aim of the study was to analyse the results of 77 total knee arthroplasties (TKA) in 52 patients with juvenile rheumatoid arthritis (JRA) using the non-constrained AGC prosthesis. Patients were operated on between the years 1985 and 1995. The mean age at the onset of disease was 7.8 years and at the time of surgery 32.7 years. Follow-ups were conducted 3 months, 1, 4, and 8 years after the operation. Additionally, an interview was arranged at the end of 1998, a mean of 7.3 (3-13) years after surgery. Secondary amyloidosis (SA) was documented in 14 (11 women) of these 52 patients. All procedures were performed using the classical method and the anteromedial parapatellar approach. The patella was resurfaced for 18 of 52 patients [in 23 of 77 knees (30%)]. Allpolyethylene components were used in three knees (13%) and metal-backed components in 20 knees (87%). During 1967-1991 a total of 37 knee synovectomies (30 knees) were performed on 23 out of these 52 patients [mean age was 20 (range 4 – 42) years at the time of synovectomy]. A total of 13 temporary epiphyseal staplings of the knee due to valgus deformity (12 knees) or leg length discrepancy (1 knee) had been performed on 9 out of the 52 patients in 1965-1982 [mean age was 8 (range 4 – 16) years at the time of epiphyseal stapling]. In addition to TKA, 65 hip arthroplasties were performed on 36 patients, 13 elbow arthroplasties on 9 patients, 8 shoulder arthroplasties on 7 patients, and 12 metacarpophalangeal implants were installed into 8 patients. When revision surgery or death of the patient were the end points, the overall survival of TKA was 99% (95% confidence interval, 92 100) during the 3-13 (mean 7.3) years of follow-up. Of the 71 knees, 53 (75%) were subjectively excellent, 18 (25%) fair and none was poor. There were no deep infections during the follow-up. Two patients died during the follow-up, the cause of death was unknown in one and traumatic in the other. One knee with a preoperative valgus angulation of 33o was revised four years after implantation because of loosening of both components. The presence of SA did not impair the survival of knee arthroplasty. The duration of the disease and the age of patients with SA at the time of surgery did not differ significantly from those without SA and there were no differences regarding patient satisfaction or functional ability. Thus, the results of TKA in the patients with JRA + SA were excellent.
A new asymptotic stability criterion for nonlinear time-variant differential equations

A new sufficient condition for asymptotic stability of ordinary differential equations is proposed. Unlike classical Lyapunov theory, the time derivative along solutions of the Lyapunov function may have positive and negative values. The classical Lyapunov approach may be regarded as an infinitesimal version of the present theorem. Verification in practical problems is harder than in the classical case; an example is included in order to indicate how the present theorem may be applied.
Effects of dietary nitrate on oxygen cost during exercise

Aim: Nitric oxide (NO), synthesized from l‐arginine by NO synthases, plays a role in adaptation to physical exercise by modulating blood flow, muscular contraction and glucose uptake and in the control of cellular respiration. Recent studies show that NO can be formed in vivo also from the reduction of inorganic nitrate (NO3−) and nitrite (NO2−). The diet constitutes a major source of nitrate, and vegetables are particularly rich in this anion. The aim of this study was to investigate if dietary nitrate had any effect on metabolic and circulatory parameters during exercise.
The Efficacy of Postoperative Prophylactic Antibiotics in Orthognathic Surgery: A Prospective Study in Le Fort I Osteotomy and Bilateral Intraoral Vertical Ramus Osteotomy

Purpose This study examined the efficacy of the postoperative prophylactic antibiotics used in orthognathic surgery. The prevalence of surgical site infections (SSIs) was determined according to the use of postoperative prophylactic antibiotics. Patients and Methods Fifty-six patients were divided into 2 groups. Each patient intravenously received 1.0 g of a third-generation cephalosporin (Cefpiramide) 30 minutes before surgery. Among them, 28 patients in the control group received 1.0 g Cefpiramide twice daily until the third day after surgery. The postoperative wounds were examined regularly for the presence of infectious signs. Results There was no significant difference in the incidence of postoperative wound infections between patients who had received postoperative prophylactic antibiotic administration and those who had not (p = 0.639). Conclusion Prolonged prophylactic antibiotic use after orthognathic surgery may not be necessary, provided that there are no other significant factors for wound infections.
The Dependence on Environment of the Color-Magnitude Relation of Galaxies

The distribution in color and absolute magnitude is presented for 55,158 galaxies taken from the Sloan Digital Sky Survey in the redshift range 0.08 < z < 0.12, as a function of the galaxy number overdensity in a cylinder of transverse radius 1 h-1 Mpc and line-of-sight half-length 8 h-1 Mpc. In all environments, bulge-dominated galaxies (defined to be those with radial profiles best fitted with large Sérsic indices) have a color-magnitude diagram dominated by red galaxies for which the mode of the color distribution at fixed absolute magnitude depends linearly on absolute magnitude. Although the most luminous galaxies reside preferentially in high-density regions and blue galaxies reside preferentially in low-density regions, there is only a barely detectable variation with overdensity in the color (zero point) or slope of the linear relation between the mode color and luminosity [<0.02 mag in 0.1 or (B-V)]. These results constrain variations with environmental density in the ages or metallicities of typical bulge-dominated galaxies to be under 20%.
Compression and cushioning characteristics of moulded pulp packaging

Experiments have been carried out to determine the relationship between the geometry of a moulded pulp packaging and the resulting static and dynamic strength. The influence of the shape of the moulded pulp sample has been examined. The shapes were of rounded and squared geometry, with different draft angles, sample heights, volumetric density in order of the level of hotpressing and surface densities. Static strength was examined by compression test. The experimental results show that cylinders, cones and shapes with large roundings produce better compression strength than squared or rectangular products with small roundings. Dynamic strength was found using drop tests to obtain G curves for first impact of the test samples at different conditions. An equation to determine the maximum G value during the drop was found. The equation shows good correlation to the results achieved for small static loads (the left side of the G curves). C/e curves for the different geometries show that the minimum cushion factor attainable for the tested moulded pulp products is approximately 2.0. Copyright © 2000 John Wiley & Sons, Ltd.
Quality of life in patients with vitiligo: an analysis of the dermatology life quality index outcome over the past two decades

Vitiligo is one of the most important skin disorders that does not cause much physical impairment, but due to its disfiguring appearance, patients have disturbances in mental health and quality of life (QoL). The dermatology life quality index (DLQI), as one of the most specific QoL instruments, is now used widely for patients with vitiligo. The main objective of this review is to collect and present detailed information about issues and disturbances related to the QoL of patients with vitiligo by reviewing the DLQI studies worldwide in the past 20 years. The impact of vitiligo assessed by the DLQI varies according to the clinical and demographic characteristics of patients. In the majority of our reviewed studies, women showed more QoL impairment than men did, as did young patients compared to elderly ones, married women with vitiligo than singles, and patients with involvement on exposed sites than those on unexposed sites. Dark‐skinned people showed more life quality effects than white people did. Dermatologists should pay particular attention to such patients who experience insufficient QoL, as they require more effort to cure their disease.
Squall-Line Intensification via Hydrometeor Recirculation

AbstractMany studies have demonstrated the intimate connection between microphysics and deep moist convection, especially for squall lines via cold pool pathways. The present study examines four numerically simulated idealized squall lines using the Regional Atmospheric Modeling System (RAMS) and includes a control simulation that uses full two-moment microphysics and three sensitivity experiments that vary the mean diameter of the hail hydrometeor size distribution. Results suggest that a circulation centered at the freezing level supports midlevel convective updraft invigoration through increased latent heating. The circulation begins with hail hydrometeors that initiate within the convective updraft above the freezing level and are then ejected upshear because of the front-to-rear flow of the squall line. As the hail falls below the freezing level, the rear-inflow jet (RIJ) advects the hail hydrometeors downshear and into the upshear flank of the midlevel convective updraft. Because the advection occur.
A critical three-way junction is conserved in budding yeast and vertebrate telomerase RNAs

The telomerase ribonucleoprotein copies a short template within its integral RNA moiety onto eukaryotic chromosome ends, compensating for incomplete replication and degradation. Non-template regions of telomerase RNA (TER) are also crucial for telomerase function, yet they are highly divergent in sequence among species and their roles are largely unclear. Using both phylogenetic and mutational analyses, we predicted secondary structures for TERs from Kluyveromyces budding yeast species. A comparison of these secondary structure models with the published model for the Saccharomyces cerevisiae TER reveals a common arrangement into three long arms, a templating domain in the center and several conserved elements in the same positions within the structure. One of them, a three-way junction element, is highly conserved in budding yeast TERs. This element also shows sequence and structure similarity to the critical CR4-CR5 activating domain of vertebrate TERs. Mutational analysis in Kluyveromyces lactis confirmed that this element, and in particular the residues conserved across yeast and vertebrates, is critical for telomerase action both in vivo and in vitro. These findings demonstrate that despite the extreme divergence of TER sequences from different organisms, they do share conserved elements, which presumably carry out common roles in telomerase function.
Resistance to high-fat diet in the female progeny of obese mice fed a control diet during the periconceptual, gestation, and lactation periods.

With the worldwide epidemic of metabolic syndrome (MetS), the proportion of women that are overweight/obese and overfed during pregnancy has increased. The resulting abnormal uterine environment may have deleterious effects on fetal metabolic programming and lead to MetS in adulthood. A balanced/restricted diet and/or physical exercise often improve metabolic abnormalities in individuals with obesity and type 2 diabetes mellitus (T2D). We investigated whether reducing fat intake during the periconceptual/gestation/lactation period in mothers with high-fat diet (HFD)-induced obesity could be used to modify fetal/neonatal MetS programming positively, thereby preventing MetS. First generation (F1) C57BL/6J female mice with HFD-induced obesity and T2D were crossed with F1 males on control diet (CD). These F1 females were switched to a CD during the periconceptual/gestation/lactation period. At weaning, both male and female second generation (F2) mice were fed a HFD. Weight, caloric intake, lipid parameters, glucose, and insulin sensitivity were assessed. Sensitivity/resistance to the HFD differed significantly between generations and sexes. A similar proportion of the F1 and F2 males (80%) developed hyperphagia, obesity, and T2D. In contrast, a significantly higher proportion of the F2 females (43%) than of the previous F1 generation (17%) were resistant (P<0.01). Despite having free access to the HFD, these female mice were no longer hyperphagic and remained lean, with normal insulin sensitivity and glycemia but mild hypercholesterolemia and glucose intolerance, thus displaying a "satiety phenotype. " This suggests that an appropriate dietary fatty acid profile and intake during the periconceptual/gestation/lactation period helps the female offspring to cope with deleterious intrauterine conditions.
Nondestructive Analysis of Nb3Sn CICC and Strand by X-Ray Tomography

The Nb3Sn cable-in-conduit conductors (CICCs) have a multistage twisted configuration. The inner structure of the CICC, such as the twist pitch and void fraction, has a substantial impact on the superconductive cable performances. X-ray tomography is a powerful nondestructive technique that can provide 3-D images of strands' configuration. Therefore, this technique is used to determine the internal structure of the cables, which, in turn, can be used to verify the cabling process and even further for modeling purposes. Additionally, scanning electron microscopy analysis has been carried out to show the interaction between strands and to characterize the filaments of the superconductive compound. Through an energy-dispersive X-ray spectroscopy analysis, a chemical characterization of the superconductive filaments was performed. The trajectory of the strands was defined by analysis of the X-ray tomography. Contacts between strands produce detachments between the central zone and the outer ring of pure copper. Regarding the superconductive filaments, the solid-state reaction performed to obtain the superconductive compound was not fully completed, and an inner central core composed of pure Nb was obtained in several filaments. In addition, a tendency of the Nb filaments to bridge together could be observed, and some cracks were seen, specially in those with an inner central core of pure Nb.