Miracle-dz/UniFAR-FTUs huggingface dataset:
Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease:The Heart and Soul Study.

CONTEXT Anxiety is common in patients with coronary heart disease (CHD), but studies examining the effect of anxiety on cardiovascular prognosis and the role of potential mediators have yielded inconsistent results. OBJECTIVES To evaluate the effect of generalized anxiety disorder (GAD) on subsequent cardiovascular events and the extent to which this association is explained by cardiac disease severity and potential behavioral or biological mediators. DESIGN Prospective cohort study (Heart and Soul Study). SETTING Participants were recruited between September 11, 2000, and December 20, 2002, from 12 outpatient clinics in the San Francisco Bay Area and were followed up until March 18, 2009. PARTICIPANTS One thousand fifteen outpatients with stable CHD followed up for a mean (SD) of 5.6 (1.8) years. MAIN OUTCOME MEASURES We determined the presence of GAD using the Diagnostic Interview Schedule. Proportional hazards models were used to evaluate the association of GAD with subsequent cardiovascular events and the extent to which this association was explained by potential confounders and mediators. RESULTS A total of 371 cardiovascular events occurred during 5711 person-years of follow-up. The age-adjusted annual rate of cardiovascular events was 9.6% in the 106 participants with GAD and 6.6% in the 909 participants without GAD (P = .03). After adjustment for demographic characteristics, comorbid conditions (including major depressive disorder), cardiac disease severity, and medication use, GAD remained associated with a 62% higher rate of cardiovascular events (hazard ratio, 1.62; 95% confidence interval, 1.11-2.37; P = .01). Additional adjustment for a variety of potential behavioral and biological mediators had little effect on this association (hazard ratio, 1.74; 95% confidence interval, 1.13-2.67; P = .01). CONCLUSIONS In outpatients with CHD, a robust association between GAD and cardiovascular events was found that could not be explained by disease severity, health behaviors, or biological mediators. How GAD leads to poor cardiovascular outcomes deserves further study.
Seasonal diet preferences of black rhinoceros in three arid South African National Parks

Black rhinoceros diet and browse availability was investigated in Augrabies Falls (AFNP), Karoo (KRNP) and Vaalbos National Parks (VNP) in South Africa. Rhino tracks were followed and 18,804 standard bite volumes recorded. Browse availability of each plant species was recorded by measuring 14,800 plants and calculating reachable browse volume. The diet comprised 51, 53 and 41 plant species in AFNP, KRNP and VNP, respectively, but three species accounted for more than 65% of the diet in each park, making diet less diverse than available browse in AFNP and KRNP. Browse availability explained 14%, 15% and 52% of diet selection in AFNP, KRNP and VNP, with consumption of most plant species significantly different from availability. A few plant species were so highly preferred that browsing intensities were unsustainable, while some common species were totally rejected. Pressure on the eaten browse averaged 4.4%, 14.5% and 1.3% annually of the volume in AFNP, KRNP and VNP. In the dry season, there was a two to sevenfold increase in browsing pressure on species with actively photosynthesizing tissues. A few key species, including Monechma and Zygophyllum species, were identified as potential early warning indicators of black rhino browsing impact.
Topodeme differentiation in Ontario taxa of Crataegus (Rosaceae: Maloideae): leaf morphometric evidence

Variation in the two-dimensional shape of short-shoot subterminal leaves was examined quantitatively in samples of nine topodemes of Crataegus section Crus-galli Loud. (representing C. crus-galli L. s.str., C. fontanesiana (Spach) Steud. , C. disperma Ashe, and C. grandis Ashe) plus three of section Punctatae Loud. (C. punctata Jacq.). Shape was described by 23 linear measurements comprising a network of box trusses. These measurements were summarized by means of sheared principal components analysis, so as to obtain two axes maximizing different size-independent contrasts in shape among the 12 samples. Topodemes of section Crus-galli were more differentiated from one another and, on the whole, less variable than those of C. punctata. These results resemble those obtained earlier with these taxa, with flower and fruit data. A probable explanation for these results is the contrasting reproductive behavior found in C. section Crus-galli (agamospermy, self-compatibility) and C. punctata (apomixis absent, se.
Impact of global change on coastal oxygen dynamics and risk of hypoxia

Climate change and changing nutrient loadings are the two main aspects of global change that are linked to the increase in the prevalence of coastal hypoxia - the depletion of oxygen in the bottom waters of coastal areas. However, it remains uncertain how strongly these two drivers will each increase the risk of hypoxia over the next decades. Through model simulations we have investigated the relative influence of climate change and nutrient run-off on the bottom water oxygen dynamics in the Oyster Grounds, an area in the central North Sea experiencing summer stratification. Simulations were performed with a one-dimensional ecosystem model that couples hydrodynamics, pelagic biogeochemistry and sediment diagenesis. Climatological conditions for the North Sea over the next 100 yr were derived from a global-scale climate model. Our results indicate that changing climatological conditions will increase the risk of hypoxia. The bottom water oxygen concentration in late summer is predicted to decrease by 24 mu M or 11.5% in the year 2100. More intense stratification is the dominant factor responsible for this decrease (58 %), followed by the reduced solubility of oxygen at higher water temperature (27 %), while the remaining part could be attributed to enhanced metabolic rates in warmer bottom waters (15 %). Relative to these climate change effects, changes in nutrient runoff are also important and may even have a stronger impact on the bottom water oxygenation. Decreased nutrient loadings strongly decrease the probability of hypoxic events. This stresses the importance of continued eutrophication management in coastal areas, which could function as a mitigation tool to counteract the effects of rising temperatures.
iTRAQ Quantitative Proteomic Analysis of Vitreous from Patients with Retinal Detachment

Rhegmatogenous retinal detachment (RRD) is a potentially blinding condition characterized by a physical separation between neurosensory retina and retinal pigment epithelium. Quantitative proteomics can help to understand the changes that occur at the cellular level during RRD, providing additional information about the molecular mechanisms underlying its pathogenesis. In the present study, iTRAQ labeling was combined with two-dimensional LC-ESI-MS/MS to find expression changes in the proteome of vitreous from patients with RRD when compared to control samples. A total of 150 proteins were found differentially expressed in the vitreous of patients with RRD, including 96 overexpressed and 54 underexpressed. Several overexpressed proteins, several such as glycolytic enzymes (fructose-bisphosphate aldolase A, gamma-enolase, and phosphoglycerate kinase 1), glucose transporters (GLUT-1), growth factors (metalloproteinase inhibitor 1), and serine protease inhibitors (plasminogen activator inhibitor 1) are regulated by HIF-1, which suggests that HIF-1 signaling pathway can be triggered in response to RRD. Also, the accumulation of photoreceptor proteins, including phosducin, rhodopsin, and s-arrestin, and vimentin in vitreous may indicate that photoreceptor degeneration occurs in RRD. Also, the accumulation of photoreceptor proteins, including phosducin, rhodopsin, and s-arrestin, and vimentin in vitreous may indicate that photoreceptor degeneration occurs in RRD. Nevertheless, the differentially expressed proteins found in this study suggest that different mechanisms are activated after RRD to promote the survival of retinal cells through complex cellular responses.
Personalized analysis of pathway aberrance induced by sevoflurane and propofol

Anesthetic agents are used in surgical operations to reversibly reduce consciousness and pain. Sevoflurane is an inhalational anesthetic. Propofol is a short-acting intravenous general anesthetic. The mechanism of anesthetic agents at pathway level on individual patients has not been reported to date. In the present study, pathway aberrance in the human atrial tissue in response to anesthetics was examined. Microarray data of anesthesia-treated samples were downloaded from the Array Express database. Pathway information was obtained from the Reactome Pathway Database. The individual pathway aberrance score (iPAS) was introduced to identify dysregulated pathways in individual patients. The present data demonstrated 157 dysregulated pathways in the sevoflurane group, and 44 pathways were identified with the least P-values. A subset of 49 differentially expressed genes (DEGs) that were shared between the expression profiling results and the dysregulated pathways results were constructed into a co-expression network. The top 5 ranked DEGs, nuclear receptor subfamily 4 group A member 3 (NR4A3), JUNB proto-oncogene, MYC proto-oncogene, tachykinin precursor 1 and nicotinamide phosphoribosyltransferase, were identified as important in the topology analysis. In the propofol group, 87 dysregulated pathways were identified and 44 pathways had the least P-values. In total 28 DEGs were constructed into a co-expression network, of which 5 DEGs were important in the topology analysis, NR4A3, suppressor of cytokine signaling 3, cyclin dependent kinase inhibitor 1A, C-C motif chemokine ligand 2 and C-X-C motif chemokine ligand 1. A total of 72 dysregulated pathways were identified in common in the two groups. In conclusion, the two types of anesthetics induced partially similar mechanisms. The pathways enriched by DEGs, particularly those that were unique to sevoflurane and propofol, may affect surgical outcomes and aid the prevention of complications from anesthetics.
Biogeography of Australasian flightless weevils (Curculionidae, Celeuthetini) suggests permeability of Lydekker's and Wallace's Lines

The Indo‐Australian region was formed by the collision of the Australian and Asian plates, and its fauna largely reflects this dual origin. Lydekker's and Wallace's Lines represent biogeographic transition boundaries between biotas although their permeability through geological times was rarely assessed. Here, we explore the evolutionary history of flightless weevils of the tribe Celeuthetini in this geologically highly complex region. We generated a DNA sequence data set of 2236 bp comprising two nuclear and two mitochondrial markers for 62 species of the Indo‐Australian tribe Celeuthetini. We used Bayesian Inference and Maximum Likelihood to reconstruct the first molecular phylogeny of the group. Based on this phylogenetic tree, we employed the program BioGeoBEARS to infer the biogeographical history of Celeuthetini in the region. The group's radiation begun east of Wallace's Line, probably during the mid‐Eocene. We unveil multiple transgressions of Lydekker's and Wallace's Lines mostly during the Miocene with a significant role of founder‐event speciation. The phylogeny of Celeuthetini is geographically highly structured with the first lineages occurring in New Guinea and the Moluccas, and a deep divergence between two clades largely confined to Sulawesi and their respective sister clades of the Lesser Sunda Islands. Wallace's Line was crossed once from Sulawesi and three times from the Lesser Sunda Islands to Java whilst Lydekker's Line was crossed once from New Guinea to the Moluccas. Although this beetle group shows extensive local diversification with little dispersal, the biogeographical demarcations of the Australasian region appear to have been rather porous barriers to dispersal.
Estimating blue whale skin isotopic incorporation rates and baleen growth rates: Implications for assessing diet and movement patterns in mysticetes

Stable isotope analysis in mysticete skin and baleen plates has been repeatedly used to assess diet and movement patterns. Accurate interpretation of isotope data depends on understanding isotopic incorporation rates for metabolically active tissues and growth rates for metabolically inert tissues. The aim of this research was to estimate isotopic incorporation rates in blue whale skin and baleen growth rates by using natural gradients in baseline isotope values between oceanic regions. Nitrogen (δ15N) and carbon (δ13C) isotope values of blue whale skin and potential prey were analyzed from three foraging zones (Gulf of California, California Current System, and Costa Rica Dome) in the northeast Pacific from 1996–2015. We also measured δ15N and δ13C values along the lengths of baleen plates collected from six blue whales stranded in the 1980s and 2000s. Skin was separated into three strata: basale, externum, and sloughed skin. A mean (±SD) skin isotopic incorporation rate of 163±91 days was estimated by fitting a generalized additive model of the seasonal trend in δ15N values of skin strata collected in the Gulf of California and the California Current System. A mean (±SD) baleen growth rate of 15.5±2.2 cm y-1 was estimated by using seasonal oscillations in δ15N values from three whales. These oscillations also showed that individual whales have a high fidelity to distinct foraging zones in the northeast Pacific across years. The absence of oscillations in δ15N values of baleen sub-samples from three male whales suggests these individuals remained within a specific zone for several years prior to death. δ13C values of both whale tissues (skin and baleen) and potential prey were not distinct among foraging zones. Our results highlight the importance of considering tissue isotopic incorporation and growth rates when studying migratory mysticetes and provide new insights into the individual movement strategies of blue whales.
Size-Dependent Plasticity in Twinned Metal Nanowires

Face-centered cubic (FCC) metal nanowires, such as gold nanowires, are basicbuilding blocks for numerous applications of nanotechnology ranging, forexample, from electronics to self-assembly and medicine [1,2]. Therefore, it iscritically important to gain fundamental insight into their mechanical behavior atthe nanometer scale, in order to build more robust nanoscale devices. Inparticular, past atomistic simulation studies have proved that coherent twinboundaries can be strong obstacle to crystal slip in nanoscale FCC metals [3-8]. However, meaningful results related to FCC metal nanowires can only beachieved if the influences of microstructure and sample size on crystal plasticityand fracture behavior are fully understood.
Maternal serum levels of total activin‐A in first‐trimester trisomy 21 pregnancies

Maternal serum total activin‐A concentration was measured in 45 pregnancies affected by trisomy 21 and 493 control unaffected pregnancies at 10–14 weeks of gestation. In the trisomy 21 pregnancies total activin‐A concentration was significantly higher (1.36 MoM of the unaffected pregnancies) and in 16% of cases the level was above the 95th centile of normal. The log10 SD for the control group and the trisomy 21 group were 0.17 and 0.22, respectively. The median pregnancy associated plasma protein‐A (PAPP‐A) in this trisomy 21 series was 0.49 and for free β‐hCG was 2.05. In the trisomy group there were significant positive associations between total activin‐A and PAPP‐A (0.6071) and free β‐hCG (0.4255). The low median difference and the high overlap in values between trisomic and unaffected pregnancies make total activin‐A of little practical use in first‐trimester screening for trisomy 21. Copyright © 2001 John Wiley & Sons, Ltd.
Can Twitter be used to predict county excessive alcohol consumption rates?

Objectives The current study analyzes a large set of Twitter data from 1,384 US counties to determine whether excessive alcohol consumption rates can be predicted by the words being posted from each county. Methods Data from over 138 million county-level tweets were analyzed using predictive modeling, differential language analysis, and mediating language analysis. Results Twitter language data captures cross-sectional patterns of excessive alcohol consumption beyond that of sociodemographic factors (e.g. age, gender, race, income, education), and can be used to accurately predict rates of excessive alcohol consumption. Additionally, mediation analysis found that Twitter topics (e.g. ‘ready gettin leave’) can explain much of the variance associated between socioeconomics and excessive alcohol consumption. Conclusions Twitter data can be used to predict public health concerns such as excessive drinking. Using mediation analysis in conjunction with predictive modeling allows for a high portion of the variance associated with socioeconomic status to be explained.
A journey from the outskirts to the cores of groups : I. Color- and mass-segregation in 20K-zCOSMOS groups

Context. Studying theevolution of galaxies located within groups may have important implications for our understanding of the global evolution of the galaxy population as a whole. The fraction of galaxies bound in groups at z ~ 0 is as high as 60% and therefore any mechanism (among the many suggested) that could quench star formation when a galaxy enters group environment would be an important driver for galaxy evolution. Aims: Using the group catalog obtained from zCOSMOS spectroscopic data and the complementary photometric data from the COSMOS survey, we explore segregation effects occurring in groups of galaxies at intermediate/high redshifts. Our aim is to reveal if, and how significantly, group environment affects the evolution of infalling galaxies. Methods: We built two composite groups at intermediate (0.2 ≤ z ≤ 0.45) and high (0.45 <z ≤ 0.8) redshifts, and we divided the corresponding composite group galaxies into three samples according to their distance from the group center. The samples roughly correspond to galaxies located in a group's inner core, intermediate, and infall region. We explored how galaxy stellar masses and colors - working in narrow bins of stellar masses - vary as a function of the galaxy distance from the group center. Results: We found that the most massive galaxies in our sample (log (ℳgal/ℳsun) ≥ 10.6) do not display any strong group-centric dependence of the fractions of red/blue objects. For galaxies of lower masses (9.8 ≤ log (ℳgal/ℳsun) ≤ 10.6) there is a radial dependence in the changing mix of red and blue galaxies. This dependence is most evident in poor groups, whereas richer groups do not display any obvious trend of the blue fraction. Interestingly, mass segregation shows the opposite behavior: it is visible only in rich groups, while poorer groups have a a constant mix of galaxy stellar masses as a function of radius. Conclusions: These findings can be explained in a simple scenario where color- and mass-segregation originate from different physical processes. While dynamical friction is the obvious cause for establishing mass segregation, both starvation and galaxy-galaxy collisions are plausible mechanisms to quench star formation in groups at a faster rate than in the field. In poorer groups the environmental effects are caught in action superimposed to secular galaxy evolution. Their member galaxies display increasing blue fractions when moving from the group center to more external regions, presumably reflecting the recent accretion history of these groups. Based on observations made at the European Southern Observatory (ESO) Very Large Telescope (VLT) under Large Program 175.A-0839.
A Case Study of a TPACK-Based Approach to Teacher Professional Development: Teaching Science With Blogs

This paper presents a case study of a technology professional development initiative and illustrates how a workshop approach based on technology, pedagogy, and content knowledge (TPACK) was adapted for professional learning at a school site. The case further documents how three middle school science teacher participants developed knowledge about how to teach with technology as they planned and implemented a blog activity in science over a 4-week period. The design of the professional development was informed by the underlying assumptions of the TPACK framework and characteristics for effective professional development for science and technology-enhanced teaching. To obtain insights into the particular experiences of teachers as they participated in the onsite professional development, a naturalistic case study design was used. Data collection procedures included researcher field notes during workshop sessions and lessons, videotaped classroom observations, audiotaped interviews, and teacher and student lesson artifacts. Data on teachers’ planning and lesson implementation of the blog activity to Grade 8 students were analyzed using content analysis. Overall, the results indicate that TPACK is developed through a combination of workshop experiences and immediate application of knowledge gained in the workshop into practice in the real-life teaching context.
Mixed Adenosquamous Histology is Associated with Poorer Survival of Cervical Cancer Stage 1b

Background: Evaluation of histopathological factors for women with radical hysterectomy a.m. Okabayashi for cervical cancer in stage 1bwith similar pre- and postoperative treatment Methods: Data on 141 women with cervical cancer stage 1b were revised. The local patient registry, data charts, and post mortem sections provided follow-up on survival, relapse, and re-admittance. Histopathological evaluation was performed by the same pathologist. Results: Histological evaluation showed that adenosquamous cervical cancer in stage 1b was associated with poorer survival than the pure squamous and adenomatous type (p<0.001, mixed versus pure type). Five year’s survival rate was 40 % (2-78 %) for mixed type and 92 % (87-97 %) for pure type. The mixed type was associated with glandular metastasis (p<0.02). The relapse free survival after 5 and 10 years was 88 % (82-94 %) and 83 % (75-91 %), respectively, while survival was found to be 89 % (83-95 %) and 86 % (79-93 %), respectively. The women’s age at diagnosis showed no association with histology type or survival.
Cross-Cultural Validation of the Short Form of the Physical Self-Inventory ( PSIS )

The study examined the cross-cultural validity of the short form of the Physical SelfInventory (PSI-S) among samples of adolescents speaking French, Dutch, Turkish, Italian, and Arab. A total of 4867 adolescents (1173 Belgian Flemish, 598 French, 1222 Italian, 643 Turkish, 646 Kuwaiti, and 585 Tunisian) completed the original PSI-S version, and a revised version including a positively-worded reformulation of the three negatively-worded PSI-S items. The results supported the factor validity and reliability of revised PSI-S version across all cultural groups, and its superiority when compared to the original version. Compared to confirmatory factor analyses (CFA), relying on an exploratory structural equation modeling (ESEM) measurement model further resulted in superior solution, and more cleanly differentiated factors. PSI-S responses proved to be fully invariant across cultural groups, and presented no evidence of differential item functioning (DIF) as a function of age, gender, body mass index (BMI), and sport involvement. However, the results revealed meaningful mean level differences as a function of gender, age, sport involvement, and BMI that were mostly consistent with the results from previous studies.