Miracle-dz/UniFAR-FTUs huggingface dataset:
Regularization of brane induced gravity

We study the regularization of theories of ``brane induced'' gravity in codimension $Ng1. $ The brane can be interpreted as a thin dielectric with a large dielectric constant, embedded in a higher dimensional space. The kinetic term for the higher dimensional graviton is enhanced over the brane. A four dimensional gravitation is found on the brane at distances smaller than a critical distance $rl{r}_{c},$ and is due to the exchange of a massive resonant graviton. The crossover scale ${r}_{c}$ is determined by the mass of the resonance. The suppression of the couplings of light Kaluza-Klein modes to brane matter results in a higher dimensional force law at large distances. We show that the resulting theory is free of ghosts or tachyons.
Zoonotic Cryptosporidium Species and Enterocytozoon bieneusi Genotypes in HIV-Positive Patients on Antiretroviral Therapy

ABSTRACT Molecular diagnostic tools have been used increasingly in the characterization of the transmission of cryptosporidiosis and microsporidiosis in developing countries. However, few studies have examined the distribution of Cryptosporidium species and Enterocytozoon bieneusi genotypes in AIDS patients receiving antiretroviral therapy. In the present study, 683 HIV-positive patients in the National Free Antiretroviral Therapy Program in China and 683 matched HIV-negative controls were enrolled. Cryptosporidium species and subtypes and Enterocytozoon bieneusi genotypes were detected and differentiated by PCR and DNA sequencing. The infection rates were 1.5% and 0.15% for Cryptosporidium and 5.7% and 4.2% for E. bieneusi in HIV-positive and HIV-negative participants, respectively. The majority (8/11) of Cryptosporidium cases were infections by zoonotic species, including Cryptosporidium meleagridis (5), Cryptosporidium parvum (2), and Cryptosporidium suis (1). Prevalent E. bieneusi genotypes detected, including EbpC (39), D (12), and type IV (7), were also potentially zoonotic. The common occurrence of EbpC was a feature of E. bieneusi transmission not seen in other areas. Contact with animals was a risk factor for both cryptosporidiosis and microsporidiosis. The results suggest that zoonotic transmission was significant in the epidemiology of both diseases in rural AIDS patients in China.
Physiological effects in aromatherapy

Hongratanaworakit, T. Physiological effects in aromatherapy Songklanakarin J. Sci. Technol. , 2004, 26(1) : 117-125 The effects of aromas on humans are divided into physiological and psychological effects. The physiological effect acts directly on the physical organism, the psychological effect acts via the sense of smell or olfactory system, which in turn may cause a physiological effect. This paper reviews on the physiological effects which are used for the evaluation of the effects of aromas. Physiological parameters, i.e. heart rate blood pressure, electrodermal activity, electroencephalogram, slow potential brain waves (contingent negative variation), and eye blink rate or pupil functions, are used as indices for the measurement of the aroma effects
Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat

The cannabinoid receptor‐mediated analgesic effects of 2‐arachidonoylglycerol (2‐AG) are limited by monoacylglycerol lipase (MAGL). 4‐nitrophenyl 4‐[bis (1,3‐benzodioxol‐5‐yl) (hydroxy) methyl] piperidine‐1‐carboxylate (JZL184) is a potent inhibitor of MAGL in the mouse, though potency is reportedly reduced in the rat. Here we have assessed the effects of spinal inhibition of MAGL with JZL184 on nociceptive processing in rats.
Mid-infrared luminosity as an indicator of the total infrared luminosity of galaxies

The infrared (IR) emission plays a crucial role for understanding the star formation in galaxies hidden by dust. We first examined four estimators of the IR luminosity of galaxies, L_fir (Helou et al. 1988), L_tir (Dale et al. 2001), revised version of L_tir (Dale & Helou 2002) (we denote L_tir2), and L_ir (Sanders & Mirabel 1996) by using the observed SEDs of well-known galaxies. We found that L_ir provides excellent estimates of the total IR luminosity for a variety of galaxy SEDs. The performance of L_tir2 was also found to be very good. Using L_ir, we then statistically analyzed the IRAS PSCz galaxy sample (Saunders et al. 2000) and found useful formulae relating the MIR monochromatic luminosities [L(12um) and L(25um)], and L_ir. For this purpose we constructed a subsample of 1420 galaxies with all IRAS four band (12, 25, 60, and 100um) flux densities. We found linear relations between L_ir and MIR luminosities, L(12um) and L(25um). The prediction error with 95-% confidence level is a factor of 4-5. Hence, these formulae are useful for the estimation of the total IR luminosity only from 12um or 25um observations. We further tried to make an `interpolation\' formula for galaxies at 0
Hidden Convexity in Partially Separable Optimization

The paper identifies classes of nonconvex optimization problems whose convex relaxations have optimal solutions which at the same time are global optimal solutions of the original nonconvex problems. Such a hidden convexity property was so far limited to quadratically constrained quadratic problems with one or two constraints. We extend it here to problems with some partial separable structure. Among other things, the new hidden convexity results open up the possibility to solve multi-stage robust optimization problems using certain nonlinear decision rules.
The activation of liver X receptors inhibits toll‐like receptor‐9‐induced foam cell formation

Toll‐like receptors (TLRs) are related to foam cell formation (FCF), key event in the establishment/progression of atherosclerosis. The activation of TLR2 and TLR4 can increase FCF. The aim of this study was to evaluate the role of TLR9 in FCF. Murine macrophages were treated with CpG‐ODN, TLR9 agonist, and oxidized particles of LDL (Paz‐PC) and FCF was analyzed by means of Oil Red O staining. The administration of CpG‐ODN plus Paz‐PC onto macrophages increased the amount of lipid droplets, correlated to increased levels of tumor necrosis factor (TNF)‐α, IFNβ, and IP‐10. The underlying mechanism by which TLR9 ligation influenced Paz‐PC in the FCF was NF‐κB‐ and IRF7‐dependent, as observed by higher levels of phosphorylated IκBα, increased nuclear translocation of the p65 subunit, lower levels of the total IKKα protein and higher release of interferon‐dependent cytokines, such as IP‐10. Liver X receptors (LXRs) regulate lipid cellular transport and negatively modulate TLR‐dependent signaling pathways. Indeed, the addition of GW3965, synthetic LXRs agonist, significantly reduced FCF after CpG‐ODN plus Paz‐PC stimulation. In this condition, we observed decreased levels of the nuclear translocation of the p65 subunit, related to the higher presence of LXRα into the nucleus. TNF‐α, IP‐10, and IFNβ levels were reduced by the administration of GW3965 following CpG‐ODN and Paz‐PC treatment. In conclusion, the activation of TLR9 facilitates the formation of foam cells in an NF‐κB‐ and IRF7‐dependent manner, countered by the activation of LXRs. This study further support LXRs as potential anti‐atherosclerotic target. J. Cell. Physiol. 223: 158–167, 2010. © 2009 Wiley‐Liss, Inc.
Grey Target Decision Method for a Variable Target Centre Based on the Decision Maker's Preferences

In multiattribute grey target decision making, the decision maker (DM) may have certain preferences for some attributes. The impacts of two types of DM’s preferences for some attribute values on alternatives were studied. To deal with the attribute preferences of a DM, a generalised grey target decision method was presented. The proposed method required that the index values of all alternatives were not normalised. The target centre index values can be obtained by substituting DM’s preference values for some of the original target centre index values as determined by the alternatives themselves. Following this, the proposed generalised method was used to calculate the target centre distances. A case study showed that this method of handling DM’s preferences for some attributes was effective.
Is age difference between partners associated with contraceptive use among married couples in Nigeria?

CONTEXT The likelihood that women use contraceptives may be reduced when they are considerably younger than their husband, because such age differences are often accompanied by disparities in social position, resources and life experiences, which may make marital relationships inherently unequal. METHODS Data from the 2008 Nigeria Demographic and Health Survey on 6,552 married couples in which the woman was aged 15-49 and the man was aged 15-59 were used to examine associations between partners' age difference and current contraceptive use. Associations were explored using multinomial logistic regression models that adjusted for women's and couples' characteristics. Separate analyses were conducted for couple methods (condoms, withdrawal and abstinence) and non-couple methods. RESULTS Ninety-eight percent of women were younger than their partner, and two-fifths were younger by 10 or more years. In bivariate analyses, women who were less than five years younger than their partner or were 5-9 years younger were more likely than those who were at least 10 years younger to be using a couple or non-couple contraceptive method (relative risk ratios, 1.4-2.2). However, these associations were no longer significant after adjustment for other characteristics. The measures that were most consistently related to use of couple and non-couple methods were education level, fertility intentions and household wealth. CONCLUSION Age differences between married partners are not associated with women's contraceptive use in Nigeria after adjustment for covariates. Further study is needed to understand this finding.
Flexor Tendon Tissue Engineering: Temporal Distribution of Donor Tenocytes versus Recipient Cells

Background: Tissue-engineered tendon material may address tendon shortages in mutilating hand injuries. Tenocytes from rabbit flexor tendon can be successfully seeded onto acellularized tendons that are used as tendon constructs. These constructs in vivo exhibit a population of tenocyte-like cells; however, it is not known to what extent these cells are of donor or recipient origin. Furthermore, the temporal distribution is also not known. Methods: Tenocytes from New Zealand male rabbits were cultured and seeded onto acellularized rabbit forepaw flexor tendons (n = 48). These tendon constructs were transplanted into female recipients. Tendons were examined after 3, 6, 12, and 30 weeks using fluorescent in situ hybridization to detect the Y chromosome in the male donor cells. One unseeded, acellularized allograft in each animal was used as a control. Results: The donor male tenocytes populate the epitenon and endotenon of the grafts at greater numbers than the recipient female tenocytes at 3 and 6 weeks. The donor and recipient tenocytes are present jointly in the grafts until 12 weeks. At 30 weeks, nearly all cells are recipient tenocyte-like cells. Conclusions: Donor male cells survive in decreasing numbers over time until 30 weeks. The presence of cells in tissue-engineered tendon grafts has been shown in prior studies to add to the strength of the constructs in vitro. This study shows that recipient cells can migrate into and repopulate the tendon construct. Cell seeding onto tendon material may create stronger constructs that will allow the initiation of motion earlier.
Multiple Methods for Multi-class, Multi-label ICD-10 Coding of Multi-granularity, Multilingual Death Certificates

We present concept detection and normalization experiments on the French and English CLEF eHealth 2017 death certiﬁcate datasets. For this purpose, we start from our last published system, which relied upon dictionary projection and supervised multi-class, mono-label text classiﬁcation using simple features. We extend this system in several dimensions with multi-label classiﬁcation and new features, including an additional combination of dictionary and classiﬁer. Because it only relies on the material provided by the task organizers, we could apply the same system to both the French and English datasets. Its results, registered as unoﬃcial runs, equal or exceed those of the best submitted systems.
Ovarian Cancer Screening Practices of Obstetricians and Gynecologists in Puerto Rico

Background. Ovarian cancer is the most fatal malignancy of the female genital tract and is associated with high mortality. The American Congress of Obstetricians and Gynecologists (ACOG) and the United States Preventive Services Task Force (USPSTF) recommend against screening for ovarian cancer in asymptomatic, average-risk women. Objective. To assess the ovarian cancer screening practices in asymptomatic, average-risk women among obstetricians and gynecologists (Ob/Gyn) in Puerto Rico. Methodology. From 2011 to 2012, self-administered anonymous questionnaires were mailed to all licensed obstetricians and gynecologists in PR. Results. Response rate was 25%. Overall, 53.9% were screening for the disease. Reported screening methods were CA-125 and transvaginal ultrasound (TVUS), 39.2%, TVUS only, 30.4%, and CA-125 only, 9.8%. In the logistic regression model, the odds that a given health practitioner routinely screened for ovarian cancer in the asymptomatic, average-risk population increased by 8% with every unit increase in his or her years in practice. Conclusion. The majority of the practicing Ob/Gyn in PR who participated are not following the guidelines established by the ACOG and the USPSTF for ovarian cancer screening.
The moderation effect of user-type (educators vs. students) in learning management system continuance

Prior research on learning management system (LMS) continuance focused on either the perspective of educators or that of students. Such studies fall short in advising customised intervention plans based on the user type. This paper investigates perceptions of both educators and students, and tests the moderating role of user type (educators vs. students) in determining the satisfaction and continued use of the LMS. We adopted the information systems (IS) continuance model extended with ease of use and placed user type as a moderator. We test the model by collecting data from 170 educators and 233 students in a Finnish university who use a popular LMS, Moodle. Partial least squares (PLS) technique is employed to test the possible moderation effects. The PLS analysis results revealed that user type moderates most of the relationships in the extended IS continuance model such that the relationships are stronger for students than educators.
The effect of cigarette smoking on cancer treatment-related side effects.

BACKGROUND Cigarette smoking has long been implicated in cancer development and survival. However, few studies have investigated the impact of smoking on symptom burden in cancer survivors during treatment and at survivorship stage. This study examines the influence of cigarette smoking on side effects among 947 cancer patients during and 6 months following treatment. METHODS Patients diagnosed with cancer and scheduled to receive chemotherapy and/or radiation therapy reported on current smoking status (yes, no) and total symptom burden [the sum of 12 common symptoms (fatigue, hair loss, memory, nausea, depression, sleep, pain, concentration, hot flashes, weight loss, skin problems, and dyspnea) scored on an 11-point scale ranging from 0 = "not present" to 10 = "as bad as you can imagine"] during treatment and at 6-month follow-up. The adjusted mean total symptom burden by smoking status was determined by analysis of covariance controlling for age, gender, race, education, occupation, treatment, cancer site, and Karnofsky performance score. RESULTS During treatment, smokers (S) had a significantly higher total symptom burden than nonsmokers (NS) (S = 46.3 vs. NS = 41.2; p < 0.05). At 6-month follow-up, smokers continued to report a higher total symptom burden than nonsmokers (S = 27.7 vs. NS = 21.9; p < 0.05). Participants who quit smoking before treatment levels had a total symptom burden similar to nonsmokers. CONCLUSION Smoking was associated with an increased symptom burden during and following treatments for cancer. Targeted cessation efforts for smokers to decrease symptom burden may limit the likelihood of treatment interruptions and increase quality of life following treatment.
Malignancy rate in thyroid nodules classified as Bethesda category III (AUS/FLUS).

BACKGROUND The Bethesda System for Reporting Thyroid Cytopathology is the standard for interpreting fine needle aspiration (FNA) specimens. The "atypia of undetermined significance/follicular lesion of undetermined significance" (AUS/FLUS) category, known as Bethesda Category III, has been ascribed a malignancy risk of 5-15%, but the probability of malignancy in AUS/FLUS specimens remains unclear. Our objective was to determine the risk of malignancy in thyroid FNAs categorized as AUS/FLUS at a comprehensive cancer center. METHODS The management of 541 AUS/FLUS thyroid nodule patients treated at Memorial Sloan-Kettering Cancer Center between 2008 and 2011 was analyzed. Clinical and radiologic features were examined as predictors for surgery. Target AUS/FLUS nodules were correlated with surgical pathology. RESULTS Of patients with an FNA initially categorized as AUS/FLUS, 64.7% (350/541) underwent immediate surgery, 17.7% (96/541) had repeat FNA, and 17.6% (95/541) were observed. Repeat FNA cytology was unsatisfactory in 5.2% (5/96), benign in 42.7% (41/96), AUS/FLUS in 38.5% (37/96), suspicious for follicular neoplasm in 5.2% (5/96), suspicious for malignancy in 4.2% (4/96), and malignant in 4.2% (4/96). Of nodules with two consecutive AUS/FLUS diagnoses that were resected, 26.3% (5/19) were malignant. Among all index AUS/FLUS nodules (triaged to surgery, repeat FNA, or observation), malignancy was confirmed on surgical pathology in 26.6% [CI 22.4-31.3]. Among AUS/FLUS nodules triaged to surgery, the malignancy rate was 37.8% [CI 33.1-42.8]. Incidental cancers were found in 22.3% of patients. On univariate logistic regression analysis, factors associated with triage to surgery were younger patient age (p<0.0001), increasing nodule size (p<0.0001), and nodule hypervascularity (p=0.032). CONCLUSIONS In patients presenting to a comprehensive cancer center, malignancy rates in nodules with AUS/FLUS cytology are higher than previously estimated, with 26.6-37.8% of AUS/FLUS nodules harboring cancer. These data imply that Bethesda Category III nodules in some practice settings may have a higher risk of malignancy than traditionally believed, and that guidelines recommending repeat FNA or observation merit reconsideration.
Functional diversity of supragranular GABAergic neurons in the barrel cortex

Although the neocortex forms a distributed system comprised of several functional areas, its vertical columnar organization is largely conserved across areas and species, suggesting the existence of a canonical neocortical microcircuit. In order to elucidate the principles governing the organization of such a cortical diagram, a detailed understanding of the dynamics binding different types of cortical neurons into a coherent algorithm is essential. Within this complex circuitry, GABAergic interneurons, while forming approximately only 15–20% of all cortical neurons, appear critical in maintaining a dynamic balance between excitation and inhibition. Despite their importance, cortical GABAergic neurons have not been extensively studied in vivo and their precise role in shaping the local microcircuit sensory response still remains to be determined. Their paucity, combined with their molecular, anatomical, and physiological diversity, has made it difficult to even establish a consensual nomenclature. However, recent technological advances in microscopy and mouse genetics have fostered a renewed interest in neocortical interneurons by putting them within “visible” reach of experimenters. The anatomically well-defined whisker-to-barrel pathway of the rodent is particularly amenable to studies attempting to link cortical circuit dynamics to behavior. To each whisker corresponds a discrete cortical unit equivalent to a single column, specialized in the encoding and processing of the sensory information it receives. In this review, we will focus on the functional role that each subtype of supragranular GABAergic neuron embedded within such a single neocortical unit may play in shaping the dynamics of the local circuit during somatosensory integration.
Ultra-High-Field Magnetic Resonance Spectroscopy in Psychiatry

The advantages of ultra-high-field (UHF ≥ 7T) MR have been demonstrated in a variety of MR acquisition modalities. Magnetic resonance spectroscopy (MRS) can particularly benefit from substantial gains in signal-to-noise ratio (SNR) and spectral resolution at UHF, enabling the quantification of numerous metabolites, including glutamate, glutamine, glutathione, and γ-aminobutyric acid that are relevant to psychiatric disorders. The aim of this review is to give an overview about the advantages and advances of UHF MRS and its application to psychiatric disorders. In order to provide a practical guide for potential applications of MRS at UHF, a literature review is given, surveying advantages and disadvantages of MRS at UHF. Key concepts, emerging technologies, practical considerations, and applications of UHF MRS are provided. Second, the strength of UHF MRS is demonstrated using some examples of its application in psychiatric disorders.
Insulin resistance and low-density apolipoprotein B-associated lipoviral particles in hepatitis C virus genotype 1 infection

Background The density of hepatitis C virus (HCV) in plasma is heterogeneous but the factors which influence this are poorly understood. Evidence from animal models and cell culture suggest that low-density apolipoprotein B (apoB)-associated HCV lipoviral particles (LVP) are more infectious than high-density HCV. Objective To measure LVP in patients with chronic hepatitis C genotype 1 (CHC-G1) and examine metabolic determinants of LVP load. Patients 51 patients with CHC-G1 infection. Methods Fasting lipid profiles and homeostasis model assessment of insulin resistance (HOMA-IR) were determined in 51 patients with CHC-G1. LVP and non-LVP viral load were measured by real-time PCR of plasma at density <1.07 g/ml and >1.07 g/ml, respectively, following iodixanol density gradient ultracentrifugation. The LVP ratio was calculated using the formula: LVP/(LVP + non-LVP). Results The mean LVP ratio was 0.241 but varied 25-fold (from 0.029 to 0.74). Univariate analysis showed that the LVP ratio correlated with HOMA-IR (p=0.004) and the triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio (p=0.004), but not with apoB. In multivariate analysis, HOMA-IR was the main determinant of LVP load (log10IU/ml) (R2=16.6%; p=0.037) but the TG/HDL-C ratio was the strongest predictor of the LVP ratio (R2=24.4%; p=0.019). Higher LVP ratios were associated with non-response to antiviral therapy (p=0.037) and with greater liver stiffness (p=0.001). Conclusion IR and associated dyslipidaemia are the major determinants of low-density apoB-associated LVP in fasting plasma. This provides a possible mechanism to explain why IR is associated with more rapidly progressive liver disease and poorer treatment outcomes.
Novel Morphological Findings of Human Sperm Removal by Leukocytes in In Vivo and In Vitro Conditions: Preliminary Study

Biological significance of increased number of leukocytes in ejaculate remains a subject of controversy. The aim of this research was to describe the morphological characteristics of the sperm elimination by leukocytes in in vivo and in vitro conditions using natural stimulator of the immune system—uropathogenic Escherichia coli, O75:HNT, isolated from semen.