Miracle-dz/UniFAR-FTUs huggingface dataset:
Identity and the Life Cycle. Selected Papers. By Erik H. Erikson. With a Historical Introduction by David Rapaport. New York: International Universities Press, Inc., 1959. 171 pp.

(1960). Identity and the Life Cycle. Selected Papers. By Erik H. Erikson. With a Historical Introduction by David Rapaport. New York: International Universities Press, Inc., 1959. 171 pp. The Psychoanalytic Quarterly: Vol. 29, No. 1, pp. 105-126.
Strategic Communication in MBA Curricula: A Qualitative Study of Student Outcomes

Using qualitative methods, this study demonstrates that the strategic communication curriculum is an important MBA program component. An audit was performed of syllabi used by schools teaching strategic communication as part of the Public Relations Society of America’s MBA/Business School Program. Interviews were then conducted with 20 respondents composing a purposive nonrandom sample of those who completed a course associated with Public Relations Society of America’s MBA/Business School Program. Researchers interpreted data using qualitative research approaches. Findings show that (a) crisis communication is a common topic in MBA-level strategic communication classes, (b) the inclusion of strategic communication curricula in MBA programs promotes new perspectives regarding the role of the public relations professional, (c) completion of MBA courses in strategic communication may advantageously position students for advancement in marketing and management positions, and (d) MBA students value case studies and interpretative analysis of real-world situations as part of strategic communication curricula.
‘She will know that her mother’s doing something for her’: women with intellectual disabilities assuming the mother identity

Abstract This article explores the experiences of women with intellectual disabilities in becoming a mother. The presented findings are from a grounded theory research study with 19 women with intellectual disabilities from the Czech Republic. The findings are organised around external and internal factors affecting the women’s assumption of the mother identity, with the most prominent being poverty of the participating mothers, negative attitudes towards their motherhood, and a lack of preparation for motherhood. There is a need for systemic support for mothers with intellectual disabilities, starting in adolescence with sexual education, and continued throughout adulthood, including programmes focused on skills development.
IDENTIFICATION , EVALUATION AND MEASURING OF AUTONOMOUS COOPERATION IN SUPPLY NETWORKS AND OTHER LOGISTIC SYSTEMS

The implementation of autonomous cooperation in logistic systems seems to be an appropriate method to cope with the increased requirements on competitive enterprises caused by highly dynamic and complex environments. In order to manage autonomous cooperating logistic processes efficiently, its measurement and evaluation are essential preconditions. The objective of this paper is to introduce the concept of autonomous cooperation in logistic processes and to answer the questions on how autonomous cooperation could be measured and evaluated. To obtain a comprehensive and multi-perspective picture of autonomous cooperation, the several steps of analysis are divided into two sequenced parts. The first sequence of examination contains a general perspective, which is exemplified by supply networks. The second sequence represents a specified engineering perspective of autonomous cooperation in a production logistic system.
MiRduplexSVM: A High-Performing MiRNA-Duplex Prediction and Evaluation Methodology

We address the problem of predicting the position of a miRNA duplex on a microRNA hairpin via the development and application of a novel SVM-based methodology. Our method combines a unique problem representation and an unbiased optimization protocol to learn from mirBase19.0 an accurate predictive model, termed MiRduplexSVM. This is the first model that provides precise information about all four ends of the miRNA duplex. We show that (a) our method outperforms four state-of-the-art tools, namely MaturePred, MiRPara, MatureBayes, MiRdup as well as a Simple Geometric Locator when applied on the same training datasets employed for each tool and evaluated on a common blind test set. (b) In all comparisons, MiRduplexSVM shows superior performance, achieving up to a 60% increase in prediction accuracy for mammalian hairpins and can generalize very well on plant hairpins, without any special optimization. (c) The tool has a number of important applications such as the ability to accurately predict the miRNA or the miRNA*, given the opposite strand of a duplex. Its performance on this task is superior to the 2nts overhang rule commonly used in computational studies and similar to that of a comparative genomic approach, without the need for prior knowledge or the complexity of performing multiple alignments. Finally, it is able to evaluate novel, potential miRNAs found either computationally or experimentally. In relation with recent confidence evaluation methods used in miRBase, MiRduplexSVM was successful in identifying high confidence potential miRNAs.
Why Do Change Management Strategies Fail? ---Illustrations with case studies

Change management is crucial to the survival and development of organizations, the more effectively you deal with change, the more likely you are to thrive. However there are a large number of failures of change management. Organizational change itself is a considerably complex activity; any tiny mistake in change management could lead to the failure of organizational change. Consequently this paper is impossible to encompass all factors that could result in the failure of change management. This paper attempts to explain why change management strategies fail from four perspectives (leadership, culture, people issues and quick response) that are major factors to determine whether change management is successful or not.
INFLUENCE OF SCALING AND UNFOLDING IN PCA BASED MONITORING OF NUTRIENT REMOVING BATCH PROCESS

Abstract The data set of batch biological and biotechnological processes can be organized in a three-way data matrix. In this paper the usefulness of different PCA approaches for monitoring is analyzed. Different ways of unfolding and scaling of data have been applied to a pilot-scale SBR data. PCA is used to reduce the dimensionality and to remove the non-linearity dynamic of the data. Moreover, a new method to select the number of principal components is proposed. Loadings graphics are used to determinate the predominant variables for each one. The results show that whatever model can be applied depending on the goal of the monitoring, however the models implicate possible false alarms or faults omission.
Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients.

OBJECTIVES Raltegravir is the first approved inhibitor of HIV-1 integrase (IN). In most patients, raltegravir failure is associated with mutations in the IN gene, through two different genetic pathways: 155 (N155H) or 148 (Q148K/R/H). The objective of this study was to characterize the dynamics of HIV-1 quasispecies variant populations in patients who failed to respond to raltegravir treatment. PATIENTS AND METHODS Bulk genotyping and clonal analysis were performed during the follow-up of 10 patients who failed to respond to raltegravir treatment. RESULTS Treatment failed through the 155 pathway in six patients and through the 148 pathway in two patients; two further patients switched from the 155 to the 148 pathway. In the two patients switching from the 155 to the 148 pathway, clonal analysis showed that Q148R/H and N155H mutations were present on different strands, suggesting that these two pathways are independent. This was consistent with our finding that each genetic profile was associated with different secondary mutations. We observed a greater variability among quasispecies associated with the 155 pathway, and IC(50) determinations showed that the fold resistance to raltegravir, relative to wild-type, was 10 for the N155H mutant and 50 for the G140S+Q148H mutant. CONCLUSIONS Clonal analysis strongly suggests that the two main genetic pathways, 155 and 148, involved in the development of resistance to raltegravir are independent and exclusive. Moreover, the switch of the resistance profile from 155 to 148 may be related to the higher level of resistance to raltegravir conferred by the 148 pathway and also to the higher instability of the 155 pathway.
The impact of work passion on work performance: the moderating role of P-O fit and meaningfulness of work

Our study aims to analyze the impact of auditor’s work passion on their performances, with meaningfulness of work and person organization fit (PO-fit) as moderating variables. Auditor, as a profession associated with assurance of compliance with their clients, highly requires good work passion to increase their spirit, avoid them from work saturation and improve their work quality. Therefore, our study expected that work passion positively affect work performance. Furthermore, meaningfulnes work and PO-fit were also expected to have moderating effect on the relationship of work passion on work performance. The results of regression and moderated regression analysis (MRA) on 87 samples collected from accoutants working in public accountant firm in Java, Indonesia, suggest that work passion has a positive effect on work performance. The result also shows that meaningfulnes was supported as a moderator on the relationship between work passion and work performance. However, our prediction that PO-fit could be a moderator in the effect of work passion on job performance of auditor was not supported.
The effect of facial expression and gaze direction on memory for unfamiliar faces

We report data from an experiment that investigated the influence of gaze direction and facial expression on face memory. Participants were shown a set of unfamiliar faces with either happy or angry facial expressions, which were either gazing straight ahead or had their gaze averted to one side. Memory for faces that were initially shown with angry expressions was found to be poorer when these faces had averted as opposed to direct gaze, whereas memory for individuals shown with happy faces was unaffected by gaze direction. We suggest that memory for another individual's face partly depends on an evaluation of the behavioural intention of that individual.
When Does Affective Organizational Commitment Lead to Job Performance?: Integration of Resource Perspective

To address the inconsistent findings on the relationship between affective organizational commitment and job performance, this study examines whether this relationship depends on employee’s occupational commitment and organizational tenure as measured by the stage of their employment (trial stage vs. stabilization stage). Existing evidence has shown that employees with high affective organizational commitment possess a greater willingness to exhibit higher levels of both task performance and organizational citizenship behaviors (OCBs). Integrating social exchange and resources perspectives, we argue that the actualization of such willingness is driven by the perceived value of the resources generated from this behavior. Two specific hypotheses were tested using data from 326 participants (mean age = 26.44; SD age = 4.21; 58.1% male) across two time periods. As hypothesized, occupational commitment moderated both the organizational commitment–task performance and organizational commitment–OCB relationships, while organizational tenure stage only moderated the latter link. Theoretical and practical implications are discussed.
Simple Recurrent Networks and Competition Effects in Spoken Word Recognition

Continuous mapping models of spoken word recognition such as TRACE (McClelland and Elman, 1986) make robust predictions about a wide variety of phenomena. However, most of these models are interactive activation models with preset weights, and do not provide an account of learning. Simple recurrent networks (SRNs, e.g., Elman, 1990) are continuous mapping models that can process sequential patterns and learn representations, and thus may provide an alternative to TRACE. However, it has been suggested that the features that allow SRNs to learn temporal dependencies lead them to work much like the Cohort model (e.g., Marslen-Wilson, 1987), such that items are activated by onset similarity to an input, but not by offset similarity (Norris, 1990). This would make them incompatible with TRACE and with recent results indicating that words that rhyme compete during spoken word recognition (Allopenna, Magnuson and Tanenhaus, 1998). We present simulations demonstrating that rhyme effects do emerge in SRNs, but this depends on how the training is carried out. We also find that SRN predictions provide a good fit to a series of recent studies of the time course of competition effects in spoken word recognition, including cohort, rhyme, and neighborhood density effects.
APEX mapping of H30+ in the Sgr B2 region

Context. The cosmic-ray ionization rate ζ CR of dense molecular clouds is a key parameter for their dynamics and chemistry. Aims. Variations of ζ CR are well established, but it is unclear if these are related to source column density or to Galactic location. Methods. Using the APEX telescope, we have mapped the 364 GHz line of H 3 O+ in the Sgr B2 region and observed the 307 GHz line at selected positions. With the IRAM 30-m telescope we have observed the H 18 2 O 203 GHz line at the same positions. Results. Strong H 3 O+ emission is detected over a ∼3 x 2 pc region, indicating an H 3 O + column density of 10 15 -10 16 cm -2 in an 18" beam. The H 3 O + abundance of ∼3 x 10 -9 and H 3 O + /H 2 O ratio of ∼1/50 in the Sgr B2 envelope are consistent with models with ζ CR ∼ 4 × 10 -16 s -1 , 3x lower than derived from H + 3 observations toward Sgr A, but 10× that of local dense clouds. Conclusions. The ionization rates of interstellar clouds thus seem to be to first order determined by the ambient cosmic-ray flux, while propagation effects cause a factor of ∼3 decrease from diffuse to dense clouds.
I Feel Your Voice

Cultural differences in emotion perception have been reported mainly for facial expressions and to a lesser extent for vocal expressions. However, the way in which the perceiver combines auditory and visual cues may itself be subject to cultural variability. Our study investigated cultural differences between Japanese and Dutch participants in the multisensory perception of emotion. A face and a voice, expressing either congruent or incongruent emotions, were presented on each trial. Participants were instructed to judge the emotion expressed in one of the two sources. The effect of to-be-ignored voice information on facial judgments was larger in Japanese than in Dutch participants, whereas the effect of to-be-ignored face information on vocal judgments was smaller in Japanese than in Dutch participants. This result indicates that Japanese people are more attuned than Dutch people to vocal processing in the multisensory perception of emotion. Our findings provide the first evidence that multisensory integration of affective information is modulated by perceivers’ cultural background.
Campylobacter Fetus Meningitis in Adults

AbstractThe zoonotic pathogen Campylobacter fetus is a rare cause of bacterial meningitis. Little is known about the clinical characteristics, predisposing factors and outcome of C fetus meningitis in adults.We report cases of C fetus meningitis in a nationwide cohort study of adult bacterial meningitis patients in the Netherlands and performed a review of the literature.Two patients with C fetus meningitis were identified from January 2006 through May 2015. The calculated annual incidence was 0.02 per million adults. Combined with the literature, we identified 22 patients with a median age of 48 years. An immunocompromised state was present in 16 patients (73%), mostly due to alcoholism (41%) and diabetes mellitus (27%). The source of infection was identified in 13 out of 19 patients (68%), consisting of regular contact with domestic animals in 5 and working on a farm in 4. Recurrent fever and illness was reported in 4 patients (18%), requiring prolonged antibiotic treatment. Two patients died (9%) and 3 survivors (15%) had neurological sequelae.C fetus is a rare cause of bacterial meningitis and is associated with an immunocompromised state. Based on the apparent slow clinical response seen in this limited number of cases, the authors of this study recommend a prolonged course of antimicrobial therapy when C fetus is identified as a causative agent of bacterial meningitis. Cases appeared to do best with carbapenem therapy.
Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A streptococcus M1T1 clone.

BACKGROUND The recent resurgence of invasive group A streptococcal disease has been paralleled by the emergence of the M1T1 clone. Recently, invasive disease initiation has been linked to mutations in the covR/S 2-component regulator. We investigated whether a fitness cost is associated with the covS mutation that counterbalances hypervirulence. METHODS Wild-type M1T1 group A Streptococcus and an isogenic covS-mutant strain derived from animal passage were compared for adherence to human laryngeal epithelial cells, human keratinocytes, or fibronectin; biofilm formation; and binding to intact mouse skin. Targeted mutagenesis of capsule expression of both strains was performed for analysis of its unique contribution to the observed phenotypes. RESULTS The covS-mutant bacteria showed reduced capacity to bind to epithelial cell layers as a consequence of increased capsule expression. The covS-mutant strain also had reduced capacity to bind fibronectin and to form biofilms on plastic and epithelial cell layers. A defect in skin adherence of the covS-mutant strain was demonstrated in a murine model. CONCLUSION Reduced colonization capacity provides a potential explanation for why the covS mutation, which confers hypervirulence, has not become fixed in the globally disseminated M1T1 group A Streptococcus clone, but rather may arise anew under innate immune selection in individual patients.
Has the participation of older employees in the workforce increased? Study of the total Swedish population regarding exit from working life

Aims: This study investigated: (i) the workforce participation in Sweden among older employees before and after changes in eligibility for sickness absence and unemployment compensation by a social insurance reform; and (ii) absence and early exit mechanisms from the workforce for different professions by looking at sickness benefits, disability pension and unemployment, early statutory pension, employment pension and unregistered economic supply. Methods: A register-based follow-up study of the total Swedish workforce population of 55–64-year-olds, measured in 2004 and 2011. Results: The total proportion of individuals aged 55–64 in the workforce increased between 2004 and 2011, but the increase was mostly in professions with lower educational requirements, a lower salary and dominated by women. Both in 2004 and in 2011, men in professions with higher educational requirements more often exit working life with an early statutory pension and employment pension. In contrast, professions with lower educational requirements more often absence working life with sickness benefits, disability pension and unemployment compensation than other professions in both 2004 and 2011. Conclusions: The change in regulations seems to have contributed to an overall shrinking proportion of individuals within the sickness benefit and disability pension schemes. At the same time the proportion of individuals taking an early pension has increased. The results indicated a tendency of passing on the costs of labour-market exit within different economic compensation arrangements, as well as to the individuals themselves; for example, less sickness benefit, disability pension, but more statutory pension and employment pension earlier.
Paneth Cells in Intestinal Homeostasis and Tissue Injury

Adult stem cell niches are often co-inhabited by cycling and quiescent stem cells. In the intestine, lineage tracing has identified Lgr5 + cells as frequently cycling stem cells, whereas Bmi1 +, mTert +, Hopx + and Lrig1 + cells appear to be more quiescent. Here, we have applied a non-mutagenic and cell cycle independent approach to isolate and characterize small intestinal label-retaining cells (LRCs) persisting in the lower third of the crypt of Lieberkühn for up to 100 days. LRCs do not express markers of proliferation and of enterocyte, goblet or enteroendocrine differentiation, but are positive for Paneth cell markers. While during homeostasis, LR/Paneth cells appear to play a supportive role for Lgr5 + stem cells as previously shown, upon tissue injury they switch to a proliferating state and in the process activate Bmi1 expression while silencing Paneth-specific genes. Hence, they are likely to contribute to the regenerative process following tissue insults such as chronic inflammation.
Norwegian general practitioners' knowledge and beliefs about breastfeeding, and their self-rated ability as breastfeeding counsellor

Abstract Background: Breastfeeding is considered the best infant-feeding method. Norway is one of the leading countries in terms of breastfeeding initiation and duration. To maintain this high breastfeeding rate, it is important to understand the factors that influence breastfeeding. A doctor s advice can improve the rates of breastfeeding initiation and duration, but not all doctors are competent in breastfeeding counselling. Objectives: The aim of this study was to identify the knowledge and beliefs of general practitioners (GPs) about breastfeeding in Norway and to investigate how important they considered guidance about breastfeeding initiation and duration before and after birth. Design: A questionnaire study about knowledge and beliefs according to predefined correct responses and about self-perceived competence as an advisor. Subjects: 122 GPs engaged in apprenticeship for medical students. Results: The response rate was 57%, 69 GPs participated. The questions were answered correctly according to national consensus for 49 % for the knowledge items and 64 % of the belief items. The GPs believed that their guidance was more important after than before birth. Female GPs had more confidence in their guidance ability than male GPs. Confidence in the GPs own guidance after birth was associated with knowledge about contraindications to breastfeeding. Conclusion: Although the GPs expressed beliefs favouring breastfeeding they partly lacked basic knowledge. The GPs confidence in own guidance was better after than before birth and was higher among those with more knowledge. Improved knowledge and emphasis on guidance before birth should be promoted among GPs. Key Points Breastfeeding is the best infant-feeding method. Doctors’ advice improves the rates of breastfeeding, but not all doctors have sufficient knowledge. This study mapped the knowledge and beliefs among Norwegian GPs. The study revealed that: GPs partly lacked basic knowledge to effectively promote breastfeeding. GPs had less confidence as advisers during pregnancy than after delivery. Most GPs agreed that knowledge about breastfeeding is basic and should be taught as an integral part of medical school programmes.