Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of acute demyelinating optic neuritis

Patients with typical acute monosymptomatic demyelinating optic neuritis should receive gadolinium-enhanced magnetic resonance imaging (MRI) of the brain and orbits to determine if they are at high risk for the subsequent development of clinically definite multiple sclerosis (CDMS). The presence of ≥2 white matter lesions (≥3 mm in diameter, at least 1 lesion periventricular or ovoid) indicates high risk for CDMS; the following treatment should be considered for such patients: 1. Intravenous methylprednisolone sodium succinate (1 gram IV/day for 3 days) followed by oral prednisone (1 mg/kg/day for 11 days) with 4-day taper (20 mg on day 1, 10 mg on days 2 and 4); 2. Interferon beta 1-a (Avonex 30μg intramuscularly [IM] weekly, or Rebif 22μg subcutaneously [SQ] weekly). These two drugs have been shown to reduce the short-term risk of CDMS in high risk monosymptomatic patients. In monosymptomatic patients with <2 white matter lesions, and in patients for whom CDMS has been established, IV methylprednisolone treatment followed by oral prednisone should be considered on an individual basis. Treatment in these patients may hasten visual recovery, but does not affect long-term visual outcome. Oral prednisone alone, without prior treatment with IV methylprednisolone, may increase the risk for recurrent optic neuritis and should be avoided.
Inhibitory cross‐talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress‐induced insulin resistance in skeletal muscle

Endoplasmic reticulum (ER) stress has been implicated in the pathogeneses of insulin resistance and type 2 diabetes, and extracellular signal‐regulated kinase (ERK) antagonist is an insulin sensitizer that can restore muscle insulin responsiveness in both tunicamycin‐treated muscle cells and type 2 diabetic mice. The present study was undertaken to determine whether the chemical or genetic inhibition ER stress pathway targeting by ERK results in metabolic benefits in muscle cells.
Landscape analyses and global search of knapsack problems

Presents statistical analyses of the search-space landscape of knapsack problems in due consideration of stochastic optimization. It is known from existing works that travelling salesman problems have a rugged landscape. We deal with 1000 knapsack problems where the values and the weights of the objects are arranged randomly. By introducing proper estimate values and topology, it is revealed that the landscape of these knapsack problems is a rugged landscape similar to that of the travelling salesman problems. It is assumed that the rugged landscape is a combination of a global valley-like structure and a local noise-like structure. We propose a new algorithm to estimate the optimum point by introducing the least mean square method to fit the global structure at some points selected randomly in the search space. The method does not contradict "no free lunch" theorems because of the availing features of the landscape. It is forecast that not only knapsack problems but also many practical problems have a structure which is characterized with the same measure. These results are useful in order to compose more effective optimization methods without a trial-and-error process.
Probability of Detecting Marine Predator-Prey and Species Interactions Using Novel Hybrid Acoustic Transmitter-Receiver Tags

Understanding the nature of inter-specific and conspecific interactions in the ocean is challenging because direct observation is usually impossible. The development of dual transmitter/receivers, Vemco Mobile Transceivers (VMT), and satellite-linked (e.g. GPS) tags provides a unique opportunity to better understand between and within species interactions in space and time. Quantifying the uncertainty associated with detecting a tagged animal, particularly under varying field conditions, is vital for making accurate biological inferences when using VMTs. We evaluated the detection efficiency of VMTs deployed on grey seals, Halichoerus grypus, off Sable Island (NS, Canada) in relation to environmental characteristics and seal behaviour using generalized linear models (GLM) to explore both post-processed detection data and summarized raw VMT data. When considering only post-processed detection data, only about half of expected detections were recorded at best even when two VMT-tagged seals were estimated to be within 50–200 m of one another. At a separation of 400 m, only about 15% of expected detections were recorded. In contrast, when incomplete transmissions from the summarized raw data were also considered, the ratio of complete transmission to complete and incomplete transmissions was about 70% for distances ranging from 50–1000 m, with a minimum of around 40% at 600 m and a maximum of about 85% at 50 m. Distance between seals, wind stress, and depth were the most important predictors of detection efficiency. Access to the raw VMT data allowed us to focus on the physical and environmental factors that limit a transceiver’s ability to resolve a transmitter’s identity.
A unified bifurcation analysis of sheet metal forming limits

The purpose of this study is to determine analytically the orientations of localized necks occurring in sheet metal forming processes, and obtain the corresponding forming limit diagrams (FLDs). In addition to the force equilibrium condition as adopted by other researchers, we include the moment equilibrium in this study. The shear terms due to the perturbation are found to vanish inside the localized neck of a region of deformation. This simplifies the two-dimensional problem to a one-dimensional problem. Furthermore, it is found that there are only three possible orientations for the initiation of a localized neck, i.e., two principal directions and one zero extension direction (which applies only to negative strain ratio deformations). A special case study using the von Mises yield criterion is also presented in this paper. Predictions from our unified analysis matches with the results of Hill, R. , 1952, On Discontinuous Plastic States, With Special Reference to Localized Necking in Thin Sheets, J. Mech. Phys Solids, 1, pp. 19-30. For the negative strain ratio regime (left-hand side of the FLDs), and with the results of Storen, S. , and Rice, R. , 1975, Localized Necking in Thin Sheets, J. Mech, Phys, Solids, 23, pp. 421-441. For the positive strain ratio regime (right hand-side of the FLD). When the localized neck is assumed to be in the zero extension direction for the negative strain ratio deformation, deformation theory and flow theory of plasticity give the same limit strains, and a unified solution to the limit strain is obtained. This solution is independent of the specific yield criterion used.
Anti-DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients.

OBJECTIVE Treg cells oppose autoreactive responses in several autoimmune diseases, and their frequency is reduced in systemic lupus erythematosus (SLE). In murine lupus models, treatment with anti-DNA Ig-based peptides can expand the number of Treg cells in vivo. This study was undertaken to test the possibility that functional human Treg cells can be induced by exposure to anti-DNA Ig-based peptides. METHODS Peripheral blood mononuclear cells were isolated from 36 lupus patients and 32 healthy individuals matched for ethnicity, sex, and age. Short-term culture experiments in the presence of several independent stimuli including anti-DNA Ig peptides were followed by flow cytometric analysis for identification of CD4+,CD25(high) T cells, cell sorting for in vitro suppression assays, and analysis of correlations between the expression of forkhead box P3 (FoxP3) and serologic and clinical characteristics of the SLE patients. RESULTS The number of in vitro CD4+,CD25(high) T cells increased after culture with anti-DNA Ig peptides in the SLE patients, but not in the controls. The expanded CD4+,CD25(high) T cells required FoxP3 for cell contact-mediated suppression of proliferation and interferon-gamma production in target CD4+,CD25- T cells. The induction of FoxP3 in SLE Treg cells occurred only in seropositive patients, and was correlated with anti-DNA and IgG serum titers. CONCLUSION These results suggest a new modality to reverse the functional deficit of Treg cells in SLE patients with positive autoimmune serology, and identify a new strategy to enhance immunoregulatory T cell activity in human SLE.
Strategies for building a Farsi-English SMT system from limited resources

Abstract : One of the recent tasks for machine translation research has been development of translation capabilities in a time frame as short as 100 days. Such a task requires developers to consider what can be done with relatively small amounts of data in a small time frame. This inherently limits the type and complexity of the effort to be devoted to this task. In this paper we will focus on the kinds of improvements for a Farsi-to- English translation system achieved by means of algorithmic changes, adding raw, domain-unspecific resources, and unsupervised morphological segmentation. The cumulative effect of these measures has been an improvement in BLEU scores of about 25% relative on an internal test set.
Studies on volatile organic compounds of some truffles and false truffles

Results of solid phase micro-extraction coupled to gas chromatography and mass spectrometry analyses, accomplished on sporophores of 11 species of truffles and false truffles, are reported. Volatile organic compounds (VOCs) found in Gautieria morchelliformis were dimethyl sulphide, 1,3-octadiene, 3,7-dimethyl-1,6-octadien-3-ol, amorphadiene, isoledene and cis-muurola-3,5-diene. In Hymenogaster luteus var. luteus, presence of 1,3-octadiene, 1-octen-3-ol, 3-octanone, 3-octanol and 4-acetylanisole was revealed. Two VOCs, 4-acetylanisole and β-farnesene, constituted aroma of Hymenogaster olivaceus.Melanogaster broomeanus exhibited as components of its aroma 2-methyl-1,3-butadiene, 2-methylpropanal, 2-methylpropanol, isobutyl acetate, 3,7-dimethyl-1,6-octadien-3-ol, 3-octanone and β-curcumene. VOC profile of Octavianina asterosperma was characterised by the presence of dimethyl sulphide, ethyl 2-methylpropanoate, methyl 2-methylbutanoate and 3-octanone. Tuber rufum var. rufum and Pachyphloeus conglomeratus showed the presence of dimethyl sulphide only.
Psychopathy, Homicide, and the Courts

This study investigated the effects of psychopathy on homicidal postoffense behavior, denying the charges at court, appealing the lower court conviction, and final sentencing. A sample of 546 offenders prosecuted for a homicide and convicted in Finland during the 1995—2004 period was examined. Their postoffense behavior, self-reported reasons for the killing, charges, sentences, and psychopathic traits, as measured by the Psychopathy Checklist—Revised, were coded from official file information. Offenders with high scores were more likely than others to leave the crime scene without informing anyone of the killing, to deny the charges, to be convicted for involuntary manslaughter rather than manslaughter or murder, and to receive permission from the Supreme Court to appeal their lower court sentence. Given the risk that psychopathic offenders pose for violent crime, the finding that they are able to manipulate the criminal justice system is cause for concern.
Online characterization of buggy applications running on the cloud

As Cloud platforms are becoming more popular, efficient resource management in these Cloud platforms helps the Cloud provider to deliver better quality of service to its customers. In this paper, we present an online characterization method that can identify potentially failing jobs in a Cloud platform by analyzing the jobs' resource usage profile as the job runs. We show that, by tracking the online resource consumption, we can develop a model through which we can predict whether or not a job will have an abnormal termination. We further show, using both real world and synthetic data, that our online tool can raise alarms as early as within the first 1/8th of the potentially failing job's lifetime, with a false negative rate as low as 4%. These alarms can become useful in implementing either one of the following resource-conserving Cloud management techniques: alerting clients early, de-prioritizing jobs that are likely to fail or assigning them less performant resources, deploying or up-regulating diagnostic tools for potentially faulty jobs.
Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy.

PURPOSE To test clinical proton MR spectroscopy as a noninvasive method for predicting tumor malignancy. METHODS Water-suppressed single-voxel point resolved spectroscopy in the frontal white matter of 17 healthy volunteers and 25 patients with brain tumors yielded spectra with peaks of N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine/phosphocreatine (Cre), and lactate. These peak intensities were semiquantitated as a ratio to that of the external reference. The validity of the semiquantitation was first evaluated through phantom and volunteer experiments. RESULTS The variation in measurements of the designated region in the volunteers was less than 10%. Normal ranges of NAA/reference, Cho/reference, and Cre/reference were 3.59 +/- 0.68, 1.96 +/- 0.66, and 1.53 +/- 0.64 (mean +/- SD), respectively. In 17 gliomas, the Cho/reference value in high-grade gliomas was significantly higher than in low-grade gliomas. Levels of NAA/reference were also significantly different in low-grade and high-grade malignancy. In eight meningiomas (four newly diagnosed and four recurrent), the level of Cho/reference was significantly higher in recurrent meningiomas than in normal white matter or in newly diagnosed meningiomas. CONCLUSIONS Higher grades of brain tumors in this study were associated with higher Cho/reference and lower NAA/reference values. These results suggest that clinical proton MR spectroscopy may help predict tumor malignancy.
Population structure, speciation, and introgression in the Anopheles gambiae complex.

We review here what is known about the population structure and evolutionary dynamics of members of the Anopheles gambiae complex with emphasis on the situation in West Africa. First, the importance of the 2nd chromosome inversion polymorphism is demonstrated especially in adaptation to levels of aridity, a major environmental variable in Africa. This affects the distribution of karyotypes on both a macro- and micro-geographic scale as well as temporally. Such differentiation leads to karyotypes being differentially effective transmitters of malaria and differentially susceptible to indoor residual spraying of insecticides. Second, we review the evidence that cryptic taxa, especially in An. gambiae s.s. , exist. This observation stems from both karyotype studies and molecular studies. It is abundantly clear that West African populations of An. gambiae s.s. are often not panmictic units, with premating factors evidently acting to maintain distinct genetic forms. Third, we review phylogenetic studies that have revealed the presence of introgression between the two most important vectors, An. gambiae and An. arabiensis. This is most evident for the 2nd chromosome inversions. This interpretation of phylogenetic data is consistent with a direct laboratory study indicating inversions in this chromosome are stably maintained in back-crossed populations. All of this information has led to the view that members of the An. gambiae complex are highly variable with an abundance of adaptive genetic variation. This presents a significant challenge to vector control programs designed to reduce malaria in sub-Saharan Africa.
Sexting, psychological distress and dating violence among adolescents and young adults.

BACKGROUND Sexting is the exchange of sexually explicit or provocative content (text messages, photos, and videos) via smartphone, Internet, or social networks. Recent evidence enlightened its relationships with several risk and aggressive behaviors. This study aimed to investigate the relationship between the amount of sexting, psychological distress, and dating violence in adolescents and young adults. METHOD The study involved 1,334 participants (68% females; mean age = 20.8) who completed a survey containing Kinsey Scale, Sexting Behavior Questionnaire, Conflict in Adolescent Dating Relationships Inventory, and General Health Questionnaire. RESULTS Results showed gender and sexual orientation differences: Males (vs. females) did more sexting, while non-heterosexuals (vs. heterosexuals) were more involved in sexting. Moreover, high/moderate users of sexting committed more offline and online dating violence. Regarding psychological distress, no differences were found between high and low/moderate users of sexting. CONCLUSIONS Results suggested that moderate and high use of sexting could be a risk factor for some problematic behaviors such as dating violence, even if there is not a relationship with anxiety and depression symptoms.
HIV viremia and incidence of non-Hodgkin lymphoma in patients successfully treated with antiretroviral therapy.

BACKGROUND The incidence of non-Hodgkin lymphoma (NHL) in human immunodeficiency virus (HIV)-infected patients remains high despite treatment with antiretroviral therapy (ART). METHODS We evaluated NHL incidence in HIV-infected patients followed in the Centers for AIDS Research Network of Integrated Clinical Systems who started combination ART and achieved suppression of HIV. We estimated the hazard ratio for NHL by time-varying HIV viremia categories, accounting for time-varying CD4 cell count using marginal structural models. RESULTS We observed 37 incident NHL diagnoses during 21 607 person-years of follow-up in 6036 patients (incidence rate, 171 per 100 000 person-years; 95% confidence interval [CI], 124-236). NHL incidence was high even among patients with nadir CD4 cell count >200 cells/µL (140 per 100 000 person-years [95% CI, 80-247]). Compared with ≤50 copies/mL, hazard ratios (HRs) for NHL were higher among those with HIV viremia of 51-500 copies/mL (HR current = 1.66 [95% CI, .70-3.94]; HR 3-month lagged = 2.10 [95% CI, .84-5.22]; and HR 6-month lagged = 1.46 [95% CI, .60-3.60]) and >500 copies/mL (HR current = 2.39 [95% CI, .92-6.21]; HR 3-month lagged = 3.56 [95% CI, 1.21-10.49]; and HR 6-month lagged = 2.50 [95% CI, .91-6.84]). Current HIV RNA as a continuous variable was also associated with NHL (HR = 1.42 per log10 copies/mL [95% CI, 1.05-1.92]). CONCLUSIONS Our findings demonstrate a high incidence of NHL among HIV-infected patients on ART and suggest a role of HIV viremia in the pathogenesis of NHL. Earlier initiation of potent ART and maximal continuous suppression of HIV viremia may further reduce NHL risk.
Hot Carrier Solar Cells: Controlling Thermalization in Ultrathin Devices

In operating hot carrier solar cells, a steady-state hot carrier distribution is established in the absorber in such a way that the excess kinetic energy of carriers can be collected. A high-carrier concentration is normally favorable to the formation of a nonequilibrium hot-carrier population. A small absorber thickness is thus expected to improve the efficiency of hot carrier solar cells, but no quantitative analysis of the impact of the cell thickness on its performance has been done so far. Here, the potential of efficiency improvement using thinned absorber is investigated by simulating the absorption, heat losses, and efficiency of a hot carrier solar cell with varying absorber thickness. Efficiency improvement requires efficient light trapping to maintain absorption in ultrathin layers. Solutions are proposed to achieve strong absorption in a 25-50-nm-thick absorber, resulting in cell efficiencies that are higher than the Shockley-Queisser limit corresponding to the absorber's bandgap.
Through the eye of the PLC: semantic security monitoring for industrial processes

Off-the-shelf intrusion detection systems prove an ill fit for protecting industrial control systems, as they do not take their process semantics into account. Specifically, current systems fail to detect recent process control attacks that manifest as unauthorized changes to the configuration of a plant's programmable logic controllers (PLCs). In this work we present a detector that continuously tracks updates to corresponding process variables to then derive variable-specific prediction models as the basis for assessing future activity. Taking a specification-agnostic approach, we passively monitor plant activity by extracting variable updates from the devices' network communication. We evaluate the capabilities of our detection approach with traffic recorded at two operational water treatment plants serving a total of about one million people in two urban areas. We show that the proposed approach can detect direct attacks on process control, and we further explore its potential to identify more sophisticated indirect attacks on field device measurements as well.
Retrograde Transport of Golgi-localized Proteins to the ER

The ER is uniquely enriched in chaperones and folding enzymes that facilitate folding and unfolding reactions and ensure that only correctly folded and assembled proteins leave this compartment. Here we address the extent to which proteins that leave the ER and localize to distal sites in the secretory pathway are able to return to the ER folding environment during their lifetime. Retrieval of proteins back to the ER was studied using an assay based on the capacity of the ER to retain misfolded proteins. The lumenal domain of the temperature-sensitive viral glycoprotein VSVGtsO45 was fused to Golgi or plasma membrane targeting domains. At the nonpermissive temperature, newly synthesized fusion proteins misfolded and were retained in the ER, indicating the VSVGtsO45 ectodomain was sufficient for their retention within the ER. At the permissive temperature, the fusion proteins were correctly delivered to the Golgi complex or plasma membrane, indicating the lumenal epitope of VSVGtsO45 also did not interfere with proper targeting of these molecules. Strikingly, Golgi-localized fusion proteins, but not VSVGtsO45 itself, were found to redistribute back to the ER upon a shift to the nonpermissive temperature, where they misfolded and were retained. This occurred over a time period of 15 min–2 h depending on the chimera, and did not require new protein synthesis. Significantly, recycling did not appear to be induced by misfolding of the chimeras within the Golgi complex. This suggested these proteins normally cycle between the Golgi and ER, and while passing through the ER at 40°C become misfolded and retained. The attachment of the thermosensitive VSVGtsO45 lumenal domain to proteins promises to be a useful tool for studying the molecular mechanisms and specificity of retrograde traffic to the ER.