Miracle-dz/UniFAR-FTUs huggingface dataset:
Variability in the vertical hyporheic water exchange affected by hydraulic conductivity and river morphology at a natural confluent meander bend

River confluences and their associated tributaries are key morphodynamic nodes that play important roles in controlling hydraulic geometry and hyporheic water exchange in fluvial networks. However, the existing knowledge regarding hyporheic water exchange associated with river confluence morphology is relatively scarce. On January 14 and 15, 2016, the general hydraulic and morphological characteristics of the confluent meander bend (CMB) between the Juehe River and the Haohe River in the southern region of Xi'an City, Shaanxi Province, China, were investigated. The patterns and magnitudes of vertical hyporheic water exchange (VHWE) were estimated based on a one‐dimensional heat steady‐state model, whereas the sediment vertical hydraulic conductivity (Kv) was calculated via in situ permeameter tests. The results demonstrated that 6 hydrodynamic zones and their extensions were observed at the CMB during the test period. These zones were likely controlled by the obtuse junction angle and low momentum flux ratio, influencing the sediment grain size distribution of the CMB. The VHWE patterns at the test site during the test period mostly showed upwelling flow dominated by regional groundwater discharging into the river. The occurrence of longitudinal downwelling and upwelling patterns along the meander bend at the CMB was likely subjected to the comprehensive influences of the local sinuosity of the meander bend and regional groundwater discharge and finally formed regional and local flow paths. Additionally, in dominated upwelling areas, the change in VHWE magnitudes was nearly consistent with that in Kv values, and higher values of both variables generally occurred in erosional zones near the thalweg paths of the CMB, which were mostly made up of sand and gravel. This was potentially caused by the erosional and depositional processes subjected to confluence morphology. Furthermore, lower Kv values observed in downwelling areas at the CMB were attributed to sediment clogging caused by local downwelling flow. The confluence morphology and sediment Kv are thus likely the driving factors that cause local variations in the VHWE of fluvial systems.
Domain Adaptation for Syntactic and Semantic Dependency Parsing Using Deep Belief Networks

In current systems for syntactic and semantic dependency parsing, people usually define a very high-dimensional feature space to achieve good performance. But these systems often suffer severe performance drops on out-of-domain test data due to the diversity of features of different domains. This paper focuses on how to relieve this domain adaptation problem with the help of unlabeled target domain data. We propose a deep learning method to adapt both syntactic and semantic parsers. With additional unlabeled target domain data, our method can learn a latent feature representation (LFR) that is beneficial to both domains. Experiments on English data in the CoNLL 2009 shared task show that our method largely reduced the performance drop on out-of-domain test data. Moreover, we get a Macro F1 score that is 2.32 points higher than the best system in the CoNLL 2009 shared task in out-of-domain tests.
Presurgical localization of the artery of Adamkiewicz with time-resolved 3.0-T MR angiography.

PURPOSE To evaluate the use of time-resolved magnetic resonance (MR) angiography in the presurgical localization of the artery of Adamkiewicz prior to reimplantation of the feeding intercostal artery, lumbar artery, or both during aortic aneurysm repair. MATERIALS AND METHODS This institutional review board-approved retrospective study included 68 patients (36 men, 32 women) who underwent time-resolved spinal MR angiography (0.2 mmol per kilogram of body weight gadobenate dimeglumine administered at a rate of 2.0 mL per second) performed with a 3.0-T imager with a dedicated eight-element spine coil. Images were reviewed at a three-dimensional workstation by two experienced radiologists in consensus. The artery of Adamkiewicz was identified, and the location of the feeding intercostal and/or lumbar artery was ascertained by using a five-point confidence index (scores ranged from 1 to 5). The phases in which the artery of Adamkiewicz, aorta, and great anterior radiculomedullary vein (GARV) demonstrated peak enhancement were also recorded. RESULTS The artery of Adamkiewicz and the location of the feeding intercostal and/or lumbar artery were identified with high confidence in 60 (88%) of the 68 patients. Origins of the artery of Adamkiewicz were on the left side of the body in 65% of patients and on the right side in 35%. The level of origin ranged from the T6 neuroforamina to the L1 neuroforamina. The arrival of contrast material was highly variable in this patient population, which had substantial aortic disease. The highest signal intensity in the aorta, artery of Adamkiewicz, and GARV occurred a mean of 55 seconds (range, 27-99 seconds; 95% confidence interval [CI] 51, 58), 72 seconds (range, 38-110 seconds; 95% CI: 68, 76), and 95 seconds (range, 46-156 seconds; 95% CI: 89, 101) after contrast material administration, respectively. CONCLUSION The artery of Adamkiewicz and the anterior spinal artery can be identified and differentiated from the GARV even in patients with substantially altered hemodynamics by using time-resolved 3.0-T MR angiography.
Sensitivity and specificity of rapid diagnostic tests for detection of group B streptococcal antigen in bacteremic neonates

Latex particle agglutination (LPA) testing for antigen to group B streptococcus (GBS) has been useful in the diagnosis of GBS sepsis in newborns. However, recent reports have demonstrated that the sensitivity of LPA assays may be as low as 27 to 54%. The purposes of the present study were to directly compare the abilities of four urine antigen assays to detect GBS antigen with clinical urine samples from neonates with GBS bacteremia and to evaluate the effect of the urine concentration on the sensitivities and specificities of these assays. Urine samples were collected serially from neonates with blood cultures positive for GBS or on admission from healthy full-term infants. One milliliter of urine was removed, and the remainder was concentrated to a volume of 1 ml. Unconcentrated samples were serially diluted with normal saline and were assayed to determine the highest dilution which would produce a positive test result. The Wellcogen, Bactigen, and Directigen LPA tests and ICON immunoassay were directly compared by using concentrated and unconcentrated urine specimens and urine specimens with known titers. A total of 94 urine specimens, including 61 concentrated and 75 unconcentrated specimens, from bacteremic infants were available for sensitivity testing, and 220 urine specimens from uninfected infants were available for specificity testing. There were significant differences in sensitivity among the four assays when they were performed on concentrated urine specimens, as follows: Directigen, 98%; Bactigen, 92%; ICON, 89%; Wellcogen, 68%. When the assays were performed on unconcentrated urine specimens, the Directigen (84%) and Bactigen (76%) assays were each significantly more sensitive than the ICON (59%) or Wellcogen (43%) assay. All four assays were significantly more sensitive in detecting GBS antigen in concentrated than in unconcentrated urine. The Directigen assay detected antigen in higher dilutions (geometric mean titer, 1:5) than the ICON (1:3), Bactigen (1.2), or Wellcogen (1:1) assay. The specificity was 99.5% for all four assays when concentrated urine was used and for the Bactigen, Directigen, and ICON assays when unconcentrated urine was used; the Wellcogen assay was 100% specific when unconcentrated urine was used. We conclude that there are significant differences in sensitivity but not specificity among the commercially available assays for the detection of GBS antigenuria when concentrated and unconcentrated urine specimens are tested. These differences in sensitivity may affect the abilities of clinicians to accurately diagnose GBS sepsis before culture results are available.
Generation of an Adenovirus Vector Lacking E1, E2a, E3, and All of E4 except Open Reading Frame 3

ABSTRACT Toxicity and immunity associated with adenovirus backbone gene expression is an important hurdle to overcome for successful gene therapy. Recent efforts to improve adenovirus vectors for in vivo use have focused on the sequential deletion of essential early genes. Adenovirus vectors have been constructed with the E1 gene deleted and with this deletion in combination with an E2a, E2b, or E4 deletion. We report here a novel vector (Av4orf3nBg) lacking E1, E2a, and all of E4 except open reading frame 3 (ORF3) and expressing a β-galactosidase reporter gene. This vector was generated by transfection of a plasmid carrying the full-length vector sequence into A30.S8 cells that express E1 and E2a but not E4. Production was subsequently performed in an E1-, E2a-, and E4-complementing cell line. We demonstrated with C57BL/6 mice that the Av4orf3nBg vector effected gene transfer with an efficiency comparable to that of the Av3nBg (wild-type E4) vector but that the former exhibited a higher level of β-galactosidase expression. This observation suggests that E4 ORF3 alone is able to enhance RNA levels from the β-galactosidase gene when the Rous sarcoma virus promoter is used to drive transgene expression in the mouse liver. In addition, we observed less liver toxicity in mice injected with the Av4orf3nBg vector than those injected with the Av3nBg vector at a comparable DNA copy number per cell. This study suggests that the additional deletion of E4 in an E1 and E2a deletion background may be beneficial in decreasing immunogenicity and improving safety and toxicity profiles, as well as increasing transgene capacity and expression for liver-directed gene therapy.
Contextualising Water Use in Residential Settings: A Survey of Non-Intrusive Techniques and Approaches

Water monitoring in households is important to ensure the sustainability of fresh water reserves on our planet. It provides stakeholders with the statistics required to formulate optimal strategies in residential water management. However, this should not be prohibitive and appliance-level water monitoring cannot practically be achieved by deploying sensors on every faucet or water-consuming device of interest due to the higher hardware costs and complexity, not to mention the risk of accidental leakages that can derive from the extra plumbing needed. Machine learning and data mining techniques are promising techniques to analyse monitored data to obtain non-intrusive water usage disaggregation. This is because they can discern water usage from the aggregated data acquired from a single point of observation. This paper provides an overview of water usage disaggregation systems and related techniques adopted for water event classification. The state-of-the art of algorithms and testbeds used for fixture recognition are reviewed and a discussion on the prominent challenges and future research are also included.
The Project ThermalMapper - Thermal 3D Mapping of Indoor Environments for Saving Energy

Abstract Heat and air conditioning losses in buildings and factories lead to a large amount of wasted energy. The Action Plan for Energy Efficiency of the Commission of the European Communities (2008) estimates that the largest cost-effective energy savings potential lies in residential (≈ 27%) and commercial (≈ 30%) buildings. Imagine a technology that creates a precise digital 3D model of heat distribution and heat flow enabling one to detect all sources of wasted energy and to modify buildings to reach these savings. This paper presents our overall approach to map indoor environments with thermal data in 3D.
Crack detection in concrete surfaces using image processing, fuzzy logic, and neural networks

Automation in structural health monitoring has generated a lot of interest in recent years, especially with the introduction of cheap digital cameras. This paper presents fuzzy logic and artificial neural network based models for accurate crack detection on concrete. Features are extracted from digital images of concrete surfaces using image processing which incorporates the edge detection technique. The properties of extracted features are fed into the models for detecting cracks. Two kinds of approaches have been implemented in this study: the image approach which classifies an image as a whole, and the object approach which classifies each component or object in an image into cracks and noise. The models have been tested on 205 images and evaluated on the basis of five measures of performance.
Targeted Deletion of the ERK5 MAP Kinase Impairs Neuronal Differentiation, Migration, and Survival during Adult Neurogenesis in the Olfactory Bulb

Recent studies have led to the exciting idea that adult-born neurons in the olfactory bulb (OB) may be critical for complex forms of olfactory behavior in mice. However, signaling mechanisms regulating adult OB neurogenesis are not well defined. We recently reported that extracellular signal-regulated kinase (ERK) 5, a MAP kinase, is specifically expressed in neurogenic regions within the adult brain. This pattern of expression suggests a role for ERK5 in the regulation of adult OB neurogenesis. Indeed, we previously reported that conditional deletion of erk5 in adult neurogenic regions impairs several forms of olfactory behavior in mice. Thus, it is important to understand how ERK5 regulates adult neurogenesis in the OB. Here we present evidence that shRNA suppression of ERK5 in adult neural stem/progenitor cells isolated from the subventricular zone (SVZ) reduces neurogenesis in culture. By contrast, ectopic activation of endogenous ERK5 signaling via expression of constitutive active MEK5, an upstream activating kinase for ERK5, stimulates neurogenesis. Furthermore, inducible and conditional deletion of erk5 specifically in the neurogenic regions of the adult mouse brain interferes with cell cycle exit of neuroblasts, impairs chain migration along the rostral migratory stream and radial migration into the OB. It also inhibits neuronal differentiation and survival. These data suggest that ERK5 regulates multiple aspects of adult OB neurogenesis and provide new insights concerning signaling mechanisms governing adult neurogenesis in the SVZ-OB axis.
Responder Definition in Clinical Stem Cell Trials in Cardiology: Will the Real Responder Please Stand Up?

Defining responders to cell treatment based on functional measurements in cardiac stem cell trials has been troublesome, and it may be considered as the Holy Grail. The functional recovery after myocardial infarction (MI) can range from only mild impairments and recovery to progression into heart failure at the next clinical visit regardless of the therapy given. In a clinical trial with adequate randomization, this will not pose an issue on the overall outcome of the trial. However, subgroup analyses become difficult, as the whimsical course of the disease influences the end result on top of the effect of the cell treatment. In other words, even patients who have suffered significant loss of functional cardiac capacity may still have benefited from cell therapy compared with the potential reference point of the same patient in the placebo group. Among other reasons, this can make subgroup analyses hard to interpret and potentially less informative. Proper subgroup analyses are ideally addressing true response, based on (pre)clinical hints, and are prospectively declared. Furthermore, the power needed to show specific responding groups might be beyond the number of participants included in hitherto conducted cell therapy trials. Meta-analyses including all randomized controlled studies have consistently shown significant positive effects of treatment with bone marrow mononuclear cells (BMMNCs) after MI. Stratified subgroup meta-analyses hint toward different effects with increasing age and specific functional parameters.1 Researchers have questioned the availability and quality of autologous cells harvested from patients with multiple risk factors.2 The negative effects of endogenous risk factors on bone marrow and circulating progenitor cells have been confirmed with regard to age, smoking, heart failure, diabetes mellitus, and general risk factor profiles.2 To date, it is not known if the negative effect of clinical risk factors on BMMNC function …
High resolution visual terrain classification for outdoor robots

In this paper we investigate SURF features for visual terrain classification for outdoor mobile robots. The image is divided into a grid and SURF features are calculated on the intersections of this grid. These features are then used to train a classifier that can differentiate between different terrain classes. Images of five different terrain types are taken using a single camera mounted on a mobile outdoor robot. We further introduce another descriptor, which is a modified form of the dense Daisy descriptor. Random forests are used for classification on each descriptor. Classification results of SURF and Daisy descriptors are compared with the results from traditional texture descriptors like LBP, LTP and LATP. It is shown that SURF features perform better than other descriptors at higher resolutions. Daisy features, although not better than SURF features, also perform better than the three texture descriptors at high resolution.
Biofilm Formation among Clinical and Food Isolates of Listeria monocytogenes

Objective. A total of 725 Listeria monocytogenes isolates, 607 from various foods and 118 from clinical cases of listeriosis, were investigated concerning their ability to form biofilms, at 4°C during 5 days and at 37°C during 24 h. Methods. Biofilm production was carried out on polystyrene tissue culture plates. Five L. monocytogenes isolates were tested for biofilm formation after being exposed to acidic and osmotic stress conditions. Results. Significant differences (P < 0.01) between clinical and food isolates were observed. At 37°C for 24 h, most food isolates were classified as weak or moderate biofilm formers whereas all the clinical isolates were biofilm producers, although the majority were weak. At 4°C during 5 days, 65 and 59% isolates, from food and clinical cases, respectively, were classified as weak. After both sublethal stresses, at 37°C just one of the five isolates tested was shown to be more sensitive to subsequent acidic exposure. However, at 4°C both stresses did not confer either sensitivity or resistance. Conclusions. Significant differences between isolates origin, temperature, and sublethal acidic stress were observed concerning the ability to form biofilms. Strain, origin, and environmental conditions can determine the level of biofilm production by L. monocytogenes isolates.
Severity of gambling is associated with severity of depressive symptoms in pathological gamblers

The objective of this study was to investigate the relationship between gambling severity and depressive symptoms in pathological gamblers addicted to slot machines, with the hypothesis that comorbid depressive symptoms are associated with exacerbated gambling symptoms and behavior. Twenty controls and 20 pathological gamblers with different levels of depressive symptoms were studied during slot machine gambling. We found exacerbated gambling behavior in gamblers with high compared to low levels of depressive symptoms in terms of self-reported gambling urge (P<0.01) and excitement from gambling (P<0.05), number of games played (P<0.01), and duration of gambling (P<0.05). A correlation between depressive and gambling symptoms was found (r = 0.602, P<0.01), thereby questioning which symptoms contribute to the exacerbated gambling behavior. Regression analyses showed that the symptoms influenced gambling behavior albeit in different ways. Although gambling symptoms predicted the rate of games played (P<0.001), depressive symptoms predicted gambling urge (P<0.01) and duration of gambling (P<0.05). We discuss whether gambling symptoms only co-occur with other disorders; the need to look beyond the classification of pathological gambling as an impulse control disorder; and the potential role of anhedonia in depressed gamblers.
Home is safer than the cloud!: privacy concerns for consumer cloud storage

Several studies ranked security and privacy to be major areas of concern and impediments of cloud adoption for companies, but none have looked into end-users' attitudes and practices. Not much is known about consumers' privacy beliefs and expectations for cloud storage, such as web-mail, document and photo sharing platforms, or about users' awareness of contractual terms and conditions. We conducted 36 in-depth interviews in Switzerland and India (two countries with different privacy perceptions and expectations); and followed up with an online survey with 402 participants in both countries. We study users' privacy attitudes and beliefs regarding their use of cloud storage systems. Our results show that privacy requirements for consumer cloud storage differ from those of companies. Users are less concerned about some issues, such as guaranteed deletion of data, country of storage and storage outsourcing, but are uncertain about using cloud storage. Our results further show that end-users consider the Internet intrinsically insecure and prefer local storage for sensitive data over cloud storage. However, users desire better security and are ready to pay for services that provide strong privacy guarantees. Participants had misconceptions about the rights and guarantees their cloud storage providers offers. For example, users believed that their provider is liable in case of data loss, does not have the right to view and modify user data, and cannot disable user accounts. Finally, our results show that cultural differences greatly influence user attitudes and beliefs, such as their willingness to store sensitive data in the cloud and their acceptance that law enforcement agencies monitor user accounts. We believe that these observations can help in improving users privacy in cloud storage systems.
The Impact of Recreational Activities on Aquatic Vegetation in Alpine Lakes

Tourism pressure on protected areas with attractive landscapes leads to environmental modifications. Eutrophication poses the main threat to the quality of water in alpine lakes. Even small inflows of biogenic elements can disrupt the ecological balance of these ecosystems. The aim of this study was to verify the hypothesis that recreational activities and easy access to alpine lakes contribute to changes in their ecological status. This hypothesis was verified by analyzing the presence of hydromacrophytes in two lakes of the Tatra National Park (Poland). The analysis was carried out along segments of hiking trails which were evaluated for accessibility to the studied lakes. Underwater surveys were carried out during scuba diving expeditions in 2012–2016. Submerged vegetation was evaluated in both lakes. This is the first study in Poland and one of the few projects in the world to have relied on such extensive support from scuba divers to generate highly accurate measurements. The study demonstrated that lake bottoms were extensively covered by Potamogeton friesii in the vicinity of trail segments with easy access to lakes. Our results show that tourism pressure contributes to the growth of aquatic vegetation in some areas of alpine lakes. We relied on our findings to propose several modifications to the routes of the evaluated tourist trails to minimize the impact of anthropogenic pressure on the studied lakes.