Miracle-dz/UniFAR-FTUs huggingface dataset:
Paracetamol, ibuprofen, or a combination of both drugs against knee pain: an excellent new randomised clinical trial answers old questions and suggests new therapeutic recommendations

At first glance, the title of the article published by Doherty et al 1 (see page 1534) does not promise much. Who would be interested in reading an investigation comparing two old well-known analgesics with each other or combinations of both? At a second glance, however, this cautious and excellent long-term study reveals many new and important findings which should be the basis for reconsideration of the treatment of musculoskeletal conditions with over-the-counter (OTC) analgesics. It may turn out that many of our widely-held beliefs and assumptions are wrong and that the recommendation for our patients needs to be changed. Doherty et al investigate whether the combination of ibuprofen and paracetamol is better than the active components alone. To answer this question the authors compared the efficacy and safety of paracetamol and ibuprofen as well as that of two combinations of these drugs in community-derived patients aged >40 years with chronic knee pain. In a randomised, double-blind, four-arm parallel-group active controlled trial, the short-term (day 10) and long-term (week 13) benefits and side effects of four different therapeutic regimens were analysed: 1. ibuprofen (400 mg three times a day); 2. paracetamol (1000 mg three times a day); 3. one fixed-dose combination tablet (ibuprofen 200 mg/paracetamol 500 mg (low-dose) three times a day); 4. two fixed-dose combination …
Pointwise rates of visual field progression cluster according to retinal nerve fiber layer bundles.

PURPOSE To explore whether pointwise rates of visual field progression group together in patterns consistent with retinal nerve fiber layer (RNFL) bundles. METHODS Three hundred eighty-nine eyes of 309 patients from the Advanced Glaucoma Intervention Study with ≥6 years of follow-up and ≥12 reliable visual field exams were selected. Linear and exponential regression models were used to estimate pointwise rates of change over time. Clustering of pointwise rates of progression was investigated with hierarchical cluster analysis using Pearson's correlation coefficients as distance measure and an average linkage scheme for building the hierarchy with cutoff value of r > 0.7. RESULTS The average mean deviation (±SD) was -10.9 (±5.4). The average (±SD) follow-up time and number of visual field exams were 8.1 (±1.1) years and 15.7 (±3.0), respectively. Pointwise rates of progression across the visual field grouped into clusters consistent with anatomic patterns of RNFL bundles with both linear (10 clusters) and exponential (six clusters) regression models. One hundred forty-four (37%) eyes progressed according to the two-omitting pointwise linear regression model. CONCLUSIONS ointwise rates of change in glaucoma patients cluster into regions consistent with RNFL bundle patterns. This finding validates the clinical significance of such pointwise rates. The correlations among pointwise rates of change can be used for spatial filtering purposes, facilitating detection or prediction of glaucoma progression.
‘They Employ Cleaners to Do that’: habitus in the primary classroom

Abstract Pierre Bourdieu suggests that his concept of habitus should be seen as a method; a way of thinking about the social world which invites an understanding of everyday practices as constitutive of social differences. The appeal of habitus lies in its ability to uncover social inequalities in a way that keeps agency and structure simultaneously in focus. However, there are also problems in operationalising habitus, chiefly because of the indeterminacy of the concept. In order to overcome these difficulties I have outlined four key components of habitus and attempted to delineate the aspects of habitus as method that seem most relevant to primary classrooms. Finally, drawing on ethnographic data gathered over 15 months of participant observation in two primary classrooms, the article seeks to explore through the lens of habitus how differences of gender, ‘race’ and class are produced by children in primary classrooms. Although I make no claims for my own empirical work it does suggest that habitus as .
Time-frequency kernel-based CNN for speech recognition

We propose a novel approach to generate time-frequency kernel based deep convolutional neural networks (CNN) for robust speech recognition. We give different treatments to shifting along the time and the frequency axes of speech feature representations in the 2D convolution, so as to achieve certain invariance in small frequency shifts while expanding time context size for speech input without smearing time positions of phone segments. The 2D-kernel approach allows easy implementation of deep CNNs. We present experimental results on speaker-independent phone recognition tasks of TIMIT and FFMTIMIT, where the latter was acquired using a far-field microphone and the speech data are noisy. Our results demonstrate that the proposed time-frequency kernel-based CNN gives consistent phone error reductions over frequency-domain CNN and DNN for both TIMIT and FFMTIMIT, with more benefits shown for recognizing noisy speech by using clean speech models.
Efficacy of a Rapid Response Team on Reducing the Incidence and Mortality of Unexpected Cardiac Arrests

Background Rapid Response Teams (RRTs) assess patients during early phases of deterioration to reduce patient morbidity and mortality. Objectives This study aimed to evaluate the ability of earlier medical intervention by a RRT prompted by clinical instability in patients to reduce the incidence of and mortality from unexpected cardiac arrest at our hospital. Patients and Methods A nonrandomized, population-based study before 2008 and after 2010 introduction of the Rapid Response Teams in a 300 bed private hospital. All patients were admitted to the hospital in 2008 (n = 25348) and 2010 (n = 28024). RRT (One doctor, one senior intensive care nurse and one staff nurse) attended to clinically unstable patients immediately with resuscitation drugs, fluid, and equipment. Response was activated by the bedside nurse or doctor according to predefined criteria. Main outcome measures were incidence and outcome of unexpected cardiac arrest. Results The incidence of unexpected cardiac arrest was 17 per 1000 hospital admissions (431 cases) in 2008 (before RRT intervention) and 12.45 per 1000 admissions (349 cases) in 2010 (after intervention), with mortality being 73.23% (274 patients) and 66.15% (231 patients) respectively. After adjustment for case mix the intervention was associated with a 19% reduction in the incidence of unexpected cardiac arrest (odds ratio 0.81, 95% confidence interval 0.65-0.98). Conclusions The RRT was able to detect preventable adverse events and reduce the mortality and incidence of unexpected cardiac arrests.
R&D Intensity and Acquisitions in High-Technology Industries: Evidence from the US Electronic and Electrical Equipment Industries

Theory suggests R&D intensity and acquisition activity may be either directly or inversely related. However, we know relatively little about which firms are responsible for acquisition activity in high-technology industries, which are not only R&D-intensive, but also have substantial acquisition activity in the United States. Using a panel of 217 US electronic and electrical equipment firms from 1985-93 and limited dependent variable estimation techniques, we find a substantial negative correlation between R&D-intensity and a firm's propensity to acquire. This result is surprisingly robust to numerous sensitivity tests and is significant in both the "within" and "between" dimensions of our data. Copyright 2000 by Blackwell Publishing Ltd
Gaze cueing of attention in schizophrenia: Individual differences in neuropsychological functioning and symptoms

Inhibition of return (IOR) represents a well-known mechanism of human perception that biases attentional orienting to novel locations in the environment. Behaviorally, IOR reflects slower reaction time (RT) to stimuli presented in previously cued locations. In this study, we examined within patients with schizophrenia this inhibitory aftereffect using two different cue types—eye gaze and standard peripheral cues. Results indicated that patients showed evidence of IOR, as reflected in a 3.2% slowing in RT to previously peripherally cued locations. However, for eye gaze, patients failed to show evidence of IOR and instead had 1.7% faster RT to targets presented following delay in locations that had been previously cued. This inhibitory failure correlated strongly with reduced neuropsychological performance and global symptoms ratings of attention and bizarre behavior. Reduced inhibitory aftereffect in RT for eye-gaze cues may reflect disease-related abnormalities in social attention.
The Audiences' Uses and Gratifications of TV Worship Services

In a nationwide postal survey of 946 respondents, the viewers' "uses and gratification" of Swedish broadcasted Sunday morning worship services were studied. An hypothesis that watching TV worship services is less burdensome than, but functionally similar to, attending services in church and that, as a consequence, TV services will displace church attendance, was investigated. The results show that watching TV services is experienced as less burdensome than attending church and that watching TV services, for a majority of the viewers, provides the same amount of over-all gratification as attending church. However, watching TV worship services provides different kinds of gratification than attending church. Thus, watching TV services should not be regarded as functionally similar to attending services in church. Only for Ss with poorer individual and environmental possibilities for attending church, is watching TV worship services functionally similar to attending church. For other Ss, frequent TV service viewing is associated, above all, with nonreligious experiences.
Clinical Assessment of Child and Adolescent Personality and Behavior.

All Access to Clinical Assessment Of Child And Adolescent Personality And Behavior 3rd Edition Repost PDF. Free Download Clinical Assessment Of Child And Adolescent Personality And Behavior 3rd Edition Repost PDF or Read Clinical Assessment Of Child And Adolescent Personality And Behavior 3rd Edition Repost PDF on The Most Popular Online PDFLAB. Only Register an Account to DownloadClinical Assessment Of Child And Adolescent Personality And Behavior 3rd Edition Repost PDF. Online PDF Related to Clinical Assessment Of Child And Adolescent Personality And Behavior 3rd Edition Repost . Get Access Clinical Assessment Of Child And Adolescent Personality And Behavior 3rd Edition Repost PDF and Download Clinical Assessment Of Child And Adolescent Personality And Behavior 3rd Edition Repost PDF for Free.
The Distribution of Attention Across a Talker's Face

In 2 experiments, a novel experimental paradigm investigated how spatial attention is distributed across a talker's face during auditory-visual speech discourse processing. Dots were superimposed onto several talkers' faces for 17-msec durations on the talker's left side, mouth, right side, and eyebrow area. Participants reported the locations of dots in 2 task conditions varying the presence or absence of concurrent language processing. Concurrent language processing did not interfere with spatial performance. Dot detection performance was greater for the talker's left, compared to their right, side, and for the mouth, compared to the eyebrow, area. Emotional expressiveness of the face, attractiveness, and clarity of voice pronunciation ratings were correlated with detection performance. Results support a 2-pool attention resource model of auditory-visual language processing. Results also suggest that attention engagement during multimodal language processing is primarily internally, rather than externally, driven, because attention is directed to the eye area when the talker displays low facial emotional expressiveness, and to the speaker's left side due to left hemisphere language processing, even though the right side displays greater motion.
Ablation of Lung Epithelial Cells Deregulates FGF‐10 Expression and Impairs Lung Branching Morphogenesis

Epithelial‐mesenchymal interactions are essential for tissue patterning during organogenesis. Distal lung epithelium and its adjacent mesenchyme comprise the epithelial‐mesenchymal signaling unit that regulates lung branching morphogenesis. Tissue recombination experiments have demonstrated the importance of mesenchymal signals in inducing lung epithelial differentiation and branching, but the role of the epithelium in regulating mesenchymal signals has not been well characterized. Using transgenic mice, we ablated distal lung epithelial cells during lung development by inducing the expression of a constitutively active proapoptotic Bax protein under the surfactant protein C (SP‐C) promoter. We found that epithelial cell ablation results in impaired lung branching morphogenesis, which progresses to emphysematous airspaces in the adults. Mesenchymal expression of fibroblast growth factor 10 (Fgf‐10), whose strict spatial and temporal expression is critical for proper lung branching morphogenesis, is disrupted and loses its localized pattern. Interestingly, the expression of sonic hedgehog (Shh), an epithelial gene known to modulate Fgf‐10 expression, is unchanged, indicating the existence of other distal epithelial signals that regulate mesenchymal Fgf‐10expression. We propose that distal SP‐C expressing lung epithelial cells provide essential signals for the downregulation of Fgf‐10expression in the distal mesenchyme during lung development. 292:123–130, 2009. © 2008 Wiley‐Liss, Inc.
The Coming of the 24-hour Economy?

This study mapped the changes in the timing of working hours in Belgium as reported in workers' daily work schedules, obtained from the Belgian Time-Use Surveys of 1966 and 1999. A typology of working schedules was drawn up by means of a sequence analysis. This approach showed that work performed beyond the standard times, that is, in the evening, at night, or on weekends, did not grow in importance in the intervening years. In 1999, standard working hours clearly accounted for a larger share of the work schedules of the active population. Although the analyses did certainly not corroborate the often alleged trend towards a 24-hour society in Belgium, it could be shown that certain categories of the working population are more susceptible to flexible working hours than others.
Patterns of Consumer Usage of Homeless Outreach Services

Abstract Outreach programs are a vital part of the continuum of services for the homeless. To investigate the characteristics of consumers of such programs and the services they receive, a sample of 446 clients of a homeless outreach program in New York City was divided into those who visited only once, two to three times, and four or more times during a 1-month period. Chi-square analyses revealed that the groups differed significantly with regard to previous client status, clinical diagnosis, referrals provided, and service outcome. Correspondence analyses further specified relationships between visit frequency and select characteristics. Implications of the findings for service delivery are considered.
The contest for social science: relations and representations of gender and class

Opening in the period of revolutions between 1789 and 1850, this book explores the contention over social science from above and below. It breaks away from othodox interpretations of the development of social science to explore the subject as a contest for class and gender power. The author gives a picture of the experiences which made men and women passionate about the social science project, and explores how different groups aimed at self-liberation, or power over others. She details the contribution made by working-class people and by women to the social science story, and shows how language and metaphor were used to construct social identities. This account of the production of knowledge as a contestable process, in its historical perspective, constructs a new politics of knowledge. The book may be important to those interested in social and cultural history, the history of natural and social science, gender and women's studies, social policy, social work and social action.
Intracranial Ependymoma: Long-Term Results in a Series of 21 Patients Treated with Stereotactic 125Iodine Brachytherapy

Background We evaluated the long-term outcome in patients harboring intracranial ependymomas treated with interstitial brachytherapy (IBT). Methods Twenty-one patients (M/F = 9/12; median age: 29 years; range: 8–70 years), diagnosed with intracranial ependymoma (1 WHO I, 11 WHO II, 9 WHO III) were treated with IBT using stereotactically implanted 125Iodine seeds between 1987 and 2010, either primarily, as adjuvant therapy following incomplete resection, or as salvage treatment upon tumor recurrence. Sixteen of 21 patients underwent microsurgical resection prior to IBT; in 5 patients, IBT was performed primarily after stereotactic biopsy for histological diagnosis. The cumulative tumor surface dose ranged from 50–65 Gy treating a median tumor volume of 3.6 ml (range, 0.3–11.6 ml). A median follow-up period of 105.3 months (range, 12.7–286.2 months) was evaluated. Results Actuarial 2-, 5- and 10-years overall- and disease-specific survival rates after IBT were each 90% and 100% at all times for ependymomas WHO I/II, for anaplastic ependymomas WHO III 100%, 100%, 70% and 100%, 100%, 86%, respectively. The neurological status of seven patients improved, while there was no change in 12 and deterioration in 2 patients, respectively. Follow-up MR images disclosed a complete tumor remission in 3, a partial remission in 12 and a stable disease in 6 patients. Treatment-associated morbidity only occurred in a single patient. Conclusions This study shows that stereotactic IBT for intracranial ependymomas is safe and can provide a high degree of local tumor control. Due to the low rate of side effects, IBT may evolve into an attractive alternative to microsurgery in ependymomas located in eloquent areas or as a salvage treatment.
Relationship Stability and Relationship Satisfaction in Cohabiting Gay and Lesbian Couples: A Prospective Longitudinal Test of the Contextual and Interdependence Models

This study examined the extent to which variables from the contextual model (personality traits indicative of general interpersonal competence) and variables from the interdependence model (perceived rewards from, costs to, satisfaction with, alternatives to and investments in the relationship) predicted relationship stability and linear changes in relationship satisfaction in a sample of cohabiting gay and lesbian couples assessed annually over a 4-year period. Findings were similar for gay and for lesbian couples. Demographic variables, contextual variables and interdependence variables discriminated between partners whose relationship dissolved (n = 22) and those whose relationships remained intact over the 4-year period (n = 92). Linear changes in the contextual and interdependence variables over the 4-year period predicted linear changes in the relationship satisfaction of intact couples over this same period. In analyses of both relationship stability and relationship satisfaction, variables from the interdependence model were found to mediate the effects of the contextual variables. The findings are interpreted in a framework that integrates contextual and interdependence models of relationship quality.
Protective effect of the microcatheter placed at the normal vertebral artery in intracranial stent-assisted angioplasty for vertebral artery stenosis

Rationale: A carefully designed intracranial stent-assisted angioplasty (SAA) is presented here that may prevent subsequent branch artery occlusion. Patient concerns: A 72-year-old man with a 3-month history of progressive and intermittent vertigo without any obvious trigger, accompanied by nausea. Diagnoses: Intracranial atherosclerotic disease. Interventions: the patient underwent intracranial SAA in accordance with the procedure described here. Outcomes: The patient's paroxysmal vertigo completely subsided, with no complications during the short-term follow-up. Lessons: This novel intracranial SAA procedure is safe and may reduce the risk of subsequent artery occlusion.
Dynamics of apolipoprotein E metabolism in humans.

The dynamics of human apoE metabolism were explored by examining the effects of alimentary lipemia and postheparin lipolysis on the plasma level and lipoprotein distribution of apoE. In the studies of alimentary lipemia, fasting and postprandial plasma samples were obtained from five normal adult males, each of whom drank 100 g of corn oil. Although no change in the plasma concentration of apoE accompanied alimentary lipemia, a major redistribution of apoE among lipoproteins occurred. The portion of apoE associated with triglyceride-rich lipoproteins as assessed by agarose column chromatography increased by a mean of 44%. Furthermore, in the two subjects in whom multiple postprandial samples were taken, there were striking linear correlations between plasma triglyceride concentrations and the fraction of apoE in triglyceride-rich lipoproteins (r = 0.96 and 0.73). In contrast, the plasma concentration of apoE fell in each of the seven studies of postheparin lipolysis. The fall averaged 17% of the control plasma apoE level. In hypertriglyceridemic patients, the decline in plasma triglyceride concentration preceded the decline in apoE concentration, suggesting that the decline in apoE was due to removal of remnants of triglyceride-rich lipoproteins. Lipoprotein fractionation demonstrated substantial loss of apoE from triglyceride-rich lipoproteins; the data suggested that this loss of apoE from triglyceride-rich lipoproteins was due both to removal of apoE from plasma and to transfer of apoE to an HDL fraction. During the recovery phase, as plasma triglyceride levels rose, opposite changes occurred: the plasma apoE level rose, apoE in triglyceride-rich lipoproteins increased in concentration, and apoE in HDL decreased in concentration. Furthermore, it became apparent during the recovery phase that apoE in triglyceride-rich lipoproteins was composed of two discrete subfractions. The first subfraction consisted of apoE on larger, probably recently synthesized lipoproteins; the second consisted of apoE on much smaller lipoproteins. These studies provide evidence in intact humans for a dynamic traffic of apoE between triglyceride-rich lipoproteins and high density lipoprotein. This traffic is a prominent phenomenon of normal alimentary lipemia and of lipolysis. By modulating the lipoprotein distribution of apoE, it probably plays a key functional role in lipoprotein metabolism. -Blum, C. B. Dynamics of apolipoprotein E metabolism in humans.
The Married Professional Woman: A Study in the Tolerance of Domestication.

The fact of discrimination against the woman in our society continues to accrue documentation in social science literature. It is our contention, however, that the thesis of inequality between the sexes is usually incompletely presented. The institutionalized role of women in the family (and the woman's acceptance of her traditional role) may continue to impede their achievement of equality in spite of attempts to change the economic structure of our society. Data from a recent study of dual-profession couples on the woman's desire for an egalitarian family, her career orientation, and her perception of discrimination are used to support the "tolerance of domestication" thesis.