Miracle-dz/UniFAR-FTUs huggingface dataset:
Contribution of Soft Copper Particle on Work Hardening Behavior in Ferritic Iron

Tensile tests were performed for two kinds of model alloys containing soft Cu particles or hard VC particles. Work hardening rate was obviously smaller in the Cu particle dispersion steel than in the VC particle dispersion steel. TEM observation for the cold-rolled specimens revealed the different dislocation arrangement; high density dislocations are introduced around the carbide particles in the VC steel, while dislocations are less accumulated in the Cu steel because dislocations can pass through Cu particles during plastic deformation.
A Power-Saving Model for Roadside Unit Deployment in Vehicular Networks

In this letter, we investigate the impact on connectivity metric when a power-saving model is applied to a vehicular network. An analytic model with linear time complexity is developed to compute the optimal number of active roadside units under a connectivity constraint. We provide guidelines for applying a power-saving model in a vehicular network. The results are very useful for the ministry of transportation.
Oral Mucosal Lesions Associated with Smokers and Chewers - A Case-Control Study in Chennai Population.

AIMS AND OBJECTIVES To determine the association of oral mucosal lesions in a group of Chennai population aged 15 years and above with smoking and chewing habits. To also determine the dose-response relationship of these habits associated with the risk of oral mucosal lesions. MATERIALA AND METHODS The study was undertaken with 450 subjects with smoking and/or chewing habits aged 15 years and over gathered through random selection in Chennai, India. Subjects with alcohol intake were excluded from the study. Based on the habits the study group was categorized into smokers, chewers and mixed (smoking+chewing). One hundred and fifty subjects diagnosed with oral mucosal lesions designated as "cases" and 300 lesion-free "controls", frequency matched for age, sex, habit and family income were assessed during the study. The study protocol included a visual oral soft tissue examination and a questionnaire-based interview. In addition, those requiring further examination, scalpel biopsies were performed to establish a definitive diagnosis. RESULTS Irrespective of the type of habit, 78% of cases smoked and/or chewed for more than 10 years as compared to 37.4% of the control group. Similarly, 71.3% of cases smoked and/or chewed more than 5 times per day as compared to 25.6% of the control group. Eleven habits related mucosal lesions of the oral cavity were encountered. Smoker's melanosis was the most common oral mucosal lesion followed by Oral submucous fibrosis and Leukoplakia. Dose-response relationships were observed for both duration and frequency of habits on the risk of oral mucosal lesions. CONCLUSION The result of the present study provides information on the association of oral mucosal lesions in smokers, chewers and patients with mixed habits. The mucosal lesions encountered included a few potentially malignant conditions and oral squamous cell carcinoma. Habits were more prevalent in men thus more lesions were encountered in males than in females. Moreover, increase in the duration and frequency of habits was significant predictors of risk in the case population.
General anesthesia plus ilioinguinal nerve block versus spinal anesthesia for ambulatory inguinal herniorrhapy

Objective: The aim was to evaluate general anesthesia (GA) plus ilioinguinal nerve block (IIB) versus spinal anesthesia (SA) in patients scheduled for ambulatory inguinal hernia repair regarding pain management, anesthesia recovery and reducing potential complications. Materials and Methods: A double-blind, prospective, randomized, controlled study in patients American Society of Anesthesiologists I-III randomized into two groups: GA plus IIB group, induction of anesthesia with propofol, maintenance with sevoflurane, airway management with laryngeal mask allowing spontaneous ventilation and ultrasound-guided IIB; SA group, patients who underwent spinal block with 2% mepivacaine. The study variables were pain intensity, assessed by visual analog scale, analgesic requirements until hospital discharge, time to ambulation and discharge, postoperative complications-related to both techniques and satisfaction experienced. Results: Thirty-two patients were enrolled; 16 patients in each group. The differences regarding pain were statistically significant at 2 h of admission (P < 0.001) and at discharge (P < 0.001) in favor of the GA plus ilioinguinal block group. In addition in this group, analgesic requirements were lower than SA group (P < 0.001), with times of ambulation and discharge significantly shorter. The SA group had a higher tendency to develop complications and less satisfaction. Conclusion: General anesthesia plus IIB is better than SA regarding postoperative analgesia, time to mobilization and discharge, side-effect profile and satisfaction experienced by the patients.
Annual cycles of metabolic rate are genetically determined but can be shifted by phenotypic flexibility

SUMMARY Birds have adjusted their life history and physiological traits to the characteristics of the seasonally changing environments they inhabit. Annual cycles in physiology can result from phenotypic flexibility or from variation in its genetic basis. A key physiological trait that shows seasonal variation is basal metabolic rate (BMR). We studied genetic and phenotypic variation in the annual cycles of body mass, BMR and mass-specific BMR in three stonechat subspecies (Saxicola torquata) originating from environments that differ in seasonality, and in two hybrid lines. Birds were kept in a common garden set-up, under annually variable day length and at constant temperature. We also studied whether stonechats use the proximate environmental factor temperature as a cue for changes in metabolic rate, by keeping birds at two different temperature regimes. We found that the different subspecies kept in a common environment had different annual cycles of body mass, BMR (variance: Kazakh 4.12, European 1.31, Kenyans 1.25) and mass-specific BMR (variance: Kazakh 0.042, European 0.003, Kenyans 0.013). Annual variation in metabolic measures of hybrids was intermediate or similar to that of parental species. Temperature treatment did not affect the shape of the annual cycles of metabolic rate, but metabolic rate was higher in birds kept under the variable temperature regime. The distinct annual cycles in body mass and metabolic rate in stonechat subspecies kept in a common environment indicate different genetic backgrounds rather than merely a phenotypically flexible response to proximate environmental cues. Phenotypic effects of temperature are superimposed on this genetically orchestrated annual cycle.
States' Reading Outcomes of Students Who Are d/Deaf and Hard of Hearing

Historically, researchers have identified that reading outcomes for students in upper grades who are d/Deaf and hard of hearing (d/Dhh) have typically rested around the late 3rd to early 4th grade. In recent years, wide-scale state-level testing has called into question these prognostications. The authors conducted a descriptive, multiunit, embedded-designs case study of 7 states' data from multiyear annual assessments of reading of participants in grades 3, 5, and 8, and in high school. Participants, states' definitions of reading outcomes, and states' reported reading results are described. The authors, who found that many students are reading at levels above the perceived 3rd-to-4th-grade "glass ceiling," build the case for a more hopeful look at reading outcomes for these students than that of the past and recommend approaches for acquiring wide-scale data that will allow professionals in the field to better understand reading outcomes in this population.
Ethical problems in prenatal diagnosis: A cross‐cultural survey of medical geneticists in 18 nations

In order to provide a basis for international discussion of ethics among geneticists, we surveyed the responses of medical geneticists to a questionnaire describing 14 hypothetical cases that posed ethical dilemmas. The cases were selected through discussions with leading geneticists in 12 nations, as representative of the most difficult problems of moral choice experienced in practice. Six cases involved indications for prenatal diagnosis or disclosure of information. All medical geneticists in each of 18 nations were included. Of 1053 asked to participate, 677 (64 per cent) responded. A large majority (83 per cent) would perform prenatal diagnosis for parents who oppose abortion but request the service. A smaller majority (63 per cent) would do so for maternal anxiety, and a minority (25 per cent) would perform for sex selection in the absence of X‐linked disease. Most would disclose conflicting controversial, or ambiguous test results, and two‐thirds would disclose colleagues' differences of opinion.
Macroeconomic Priorities

Macroeconomics was born as a distinct  eld in the 1940’s, as a part of the intellectual response to the Great Depression. The term then referred to the body of knowledge and expertise that we hoped would prevent the recurrence of that economic disaster. My thesis in this lecture is that macroeconomics in this original sense has succeeded: Its central problem of depression prevention has been solved, for all practical purposes, and has in fact been solved for many decades. There remain important gains in welfare from better  scal policies, but I argue that these are gains from providing people with better incentives to work and to save, not from better  ne-tuning of spending  ows. Taking U.S. performance over the past 50 years as a benchmark, the potential for welfare gains from better long-run, supply-side policies exceeds by far the potential from further improvements in short-run demand management. My plan is to review the theory and evidence leading to this conclusion. Section I outlines the general logic of quantitativewelfare analysis, in which policy comparisons are reduced to differences perceived and valued by individuals. It also provides a brief review of some examples—examples that will be familiar to many—of changes in long-run monetary and  scal policies that consumers would view as equivalent to increases of 5–15 percent in their overall consumption levels. Section II describes a thought-experiment in which a single consumer is magically relieved of all consumption variability about trend. How much average consumption would he be willing to give up in return? About one-half of onetenth of a percent, I calculate. I will defend this estimate as giving the right order of magnitude of the potential gain to society from improved stabilization policies, but to do this, many questions need to be addressed. How much of aggregate consumption variability should be viewed as pathological? How much can or should be removed by monetary and  scal means? Section III reviews evidence bearing on these questions. Section IV considers attitudes toward risk: How much do people dislike consumption uncertainty? How much would they pay to have it reduced? We also know that business-cycle risk is not evenly distributed or easily diversi ed, so welfare cost estimates that ignore this fact may badly understate the costs of  uctuations. Section V reviews recently developed models that let us explore this possibility systematically. These are hard questions, and de nitive answers are too much to ask for. But I argue in the end that, based on what we know now, it is unrealistic to hope for gains larger than a tenth of a percent from better countercyclical policies.
Role of two outer membrane antigens in the induction of protective immunity against Francisella tularensis strains of different virulence.

A crude outer membrane preparation from Francisella tularensis live vaccine strain was used to immunise mice. Immunised mice were completely protected from a F. tularensis challenge. We evaluated the role of two major outer membrane antigens in the induction of protective immunity, namely lipopolysaccharide and an outer membrane protein FopA. We presented FopA to the immune system using an aromatic amino acid dependent Salmonella typhimurium as a vector. Although mice mounted an immune response to cloned FopA no significant protection was induced. However, lipopolysaccharide-immunised mice were completely protected from a F.tularensis live vaccine strain challenge. No increase in LD50 was observed using F. tularensis Schu4 as the challenge strain, although there was a significant increase in time to death. These data question the validity of the murine F. tularensis live vaccine strain model.
G-thinker: Big Graph Mining Made Easier and Faster

This paper proposes a general system for compute-intensive graph mining tasks that find from a big graph all subgraphs that satisfy certain requirements (e.g., graph matching and community detection). Due to the broad range of applications of such tasks, many single-threaded algorithms have been proposed. However, graphs such as online social networks and knowledge graphs often have billions of vertices and edges, which require distributed processing in order to scale. Unfortunately, existing distributed graph processing systems such as Pregel and GraphLab are designed for data-intensive analytics, and are inefficient for compute-intensive graph mining tasks since computation over any data is coupled with the data's access that involves network transmission. We propose a distributed graph mining framework, called G-thinker, which is designed for compute-intensive graph mining workloads. G-thinker provides an intuitive graph-exploration API for the convenient implementation of various graph mining algorithms, and the runtime engine provides efficient execution with bounded memory consumption, light network communication, and parallelism between computation and communication. Extensive experiments were conducted, which demonstrate that G-thinker is orders of magnitude faster than existing solution, and can scale to graphs that are two orders of magnitude larger given the same hardware resources.
Determinants of Sustained Viral Suppression in HIV-Infected Patients with Self-Reported Poor Adherence to Antiretroviral Therapy

Background Good adherence to antiretroviral therapy (ART) is critical for successful HIV treatment. However, some patients remain virologically suppressed despite suboptimal adherence. We hypothesized that this could result from host genetic factors influencing drug levels. Methods Eligible individuals were Caucasians treated with efavirenz (EFV) and/or boosted lopinavir (LPV/r) with self-reported poor adherence, defined as missing doses of ART at least weekly for more than 6 months. Participants were genotyped for single nucleotide polymorphisms (SNPs) in candidate genes previously reported to decrease EFV (rs3745274, rs35303484, rs35979566 in CYP2B6) and LPV/r clearance (rs4149056 in SLCO1B1, rs6945984 in CYP3A, rs717620 in ABCC2). Viral suppression was defined as having HIV-1 RNA <400 copies/ml throughout the study period. Results From January 2003 until May 2009, 37 individuals on EFV (28 suppressed and 9 not suppressed) and 69 on LPV/r (38 suppressed and 31 not suppressed) were eligible. The poor adherence period was a median of 32 weeks with 18.9% of EFV and 20.3% of LPV/r patients reporting missed doses on a daily basis. The tested SNPs were not determinant for viral suppression. Reporting missing >1 dose/week was associated with a lower probability of viral suppression compared to missing 1 dose/week (EFV: odds ratio (OR) 0.11, 95% confidence interval (CI): 0.01–0.99; LPV/r: OR 0.29, 95% CI: 0.09–0.94). In both groups, the probability of remaining suppressed increased with the duration of continuous suppression prior to the poor adherence period (EFV: OR 3.40, 95% CI: 0.62–18.75; LPV/r: OR 5.65, 95% CI: 1.82–17.56). Conclusions The investigated genetic variants did not play a significant role in the sustained viral suppression of individuals with suboptimal adherence. Risk of failure decreased with longer duration of viral suppression in this population.
Aberrant promoter methylation of multiple genes in malignant ovarian tumors and in ovarian tumors with low malignant potential

Methylation‐mediated suppression of detoxification, DNA repair, and tumor suppressor genes has been implicated in cancer development and progression. Studies also have indicated that concordant methylation of multiple genes (methylator phenotypes), rather than a single gene, may predict cancer prognosis. The current study was designed to determine whether a methylator phenotype exists in ovarian cancer, whether methylation frequencies differ between malignant ovarian tumors and ovarian tumors with low malignant potential (LMP or borderline), and whether methylation of multiple genes affects patient survival.
Utility of lesion diameter in the clinical diagnosis of cutaneous melanoma.

OBJECTIVE To determine the utility of the current diameter criterion of larger than 6 mm of the ABCDE acronym for the early diagnosis of cutaneous melanoma. DESIGN Cohort study. SETTING Dermatology hospital-based clinics and community practice offices. Patients A total of 1323 patients undergoing skin biopsies of 1657 pigmented lesions suggestive of melanoma. MAIN OUTCOME MEASURE The maximum lesion dimension (diameter) of each skin lesion was calculated before biopsy using a novel computerized skin imaging system. RESULTS Of 1657 biopsied lesions, 853 (51.5%) were 6 mm or smaller in diameter. Invasive melanomas were diagnosed in 13 of 853 lesions (1.5%) that were 6 mm or smaller in diameter and in 41 of 804 lesions (5.1%) that were larger than 6 mm in diameter. In situ melanomas were diagnosed in 22 of 853 lesions (2.6%) that were 6 mm or smaller in diameter and in 62 of 804 lesions (7.7%) that were larger than 6 mm in diameter. Conclusion The diameter guideline of larger than 6 mm provides a useful parameter for physicians and should continue to be used in combination with the A, B, C, and E criteria previously established in the selection of atypical lesions for skin biopsy.
A Single Mechanism Can Explain the Speed Tuning Properties of MT and V1 Complex Neurons

A recent study by Priebe et al., (2006) has shown that a small proportion (27%) of primate directionally selective, complex V1 neurons are tuned for the speed of image motion. In this study, I show that the weighted intersection mechanism (WIM) model, which was previously proposed to explain speed tuning in middle temporal neurons, can also explain the tuning found in complex V1 neurons. With the addition of a contrast gain mechanism, this model is able to replicate the effects of contrast on V1 speed tuning, a phenomenon that was recently discovered by Priebe et al., (2006). The WIM model simulations also indicate that V1 neuron spatiotemporal frequency response maps may be asymmetrical in shape and hence poorly characterized by the symmetrical two-dimensional Gaussian fitting function used by Priebe et al., (2006) to classify their cells. Therefore, the actual proportion of speed tuning among directional complex V1 cells may be higher than the 27% estimate suggested by these authors.
Adaptive Frame Methods for Magnetohydrodynamic Flows

In this paper we develop adaptive numerical schemes for certain nonlinear variational problems. The discretization of the variational problems is done by a suitable frame decomposition of the solution, i.e., a complete, stable, and redundant expansion. The discretization yields an equivalent nonlinear problem on l2(N), the space of frame coefficients. The discrete problem is then adaptively solved using approximated nested fixed point and Richardson type iterations. We investigate the convergence, stability, and optimal complexity of the scheme. This constitutes a theoretical advantage, for example, with respect to adaptive finite element schemes for which convergence and complexity results are usually hard to prove. The use of frames is further motivated by their redundancy, which, at least numerically, has been shown to improve the conditioning of the corresponding discretization matrices. Also frames are usually easier to construct than Riesz bases. Finally, we show how to apply the adaptive scheme we propose for finding an approximation to the solution of the PDE governing magnetohydrodynamic (MHD) flows, once suitable frames are constructed.
Structure of a human translation termination complex

In contrast to bacteria that have two release factors, RF1 and RF2, eukaryotes only possess one unrelated release factor eRF1, which recognizes all three stop codons of the mRNA and hydrolyses the peptidyl-tRNA bond. While the molecular basis for bacterial termination has been elucidated, high-resolution structures of eukaryotic termination complexes have been lacking. Here we present a 3.8 Å structure of a human translation termination complex with eRF1 decoding a UAA(A) stop codon. The complex was formed using the human cytomegalovirus (hCMV) stalling peptide, which perturbs the peptidyltransferase center (PTC) to silence the hydrolysis activity of eRF1. Moreover, unlike sense codons or bacterial stop codons, the UAA stop codon adopts a U-turn-like conformation within a pocket formed by eRF1 and the ribosome. Inducing the U-turn conformation for stop codon recognition rationalizes how decoding by eRF1 includes monitoring geometry in order to discriminate against sense codons.
Genetic admixture of burbot (Teleostei: Lota lota) in Lake Constance from two European glacial refugia

The burbot, Lota lota, is the only freshwater species of the codfish family and has a Holarctic distribution. Pleistocene glaciations caused significant geographical differentiation in the past, but its life history characterized by winter spawning migrations over large distances is likely to homogenize populations by contemporary gene flow. We investigated the population genetic structure of 541 burbots from Lake Constance and adjacent Rhine and Danube tributaries in Europe using the entire mitochondrial DNA (mtDNA) control region and 11 microsatellites. Microsatellites revealed considerable population divergence (FST = 0.26) and evidenced recent bottlenecks in two Central European rivers. In accordance to previous evidence two main phylogeographic lineages (Atlantic and Danubian) were found co‐occurring at similar frequencies in Lake Constance, where they currently undergo random mating as indicated by microsatellites. The Danubian lineage contributed only a small proportion to the lake's mtDNA diversity, and probably expanded within the lake shortly after its formation ∼10 000–15 000 bp. The larger Atlantic haplotype diversity suggested a population expansion older than the lake itself. Levels of admixture at microsatellite loci were less obvious due to their high variability, and coalescence methods were used to estimate past admixture proportions. Our results reinforce a model of a two‐step colonization of Europe by burbot from an ancestral Danubian refuge, and confirm the persistence of a secondary Atlantic refuge, as proposed to exist for other freshwater fish. We conclude that the present‐day burbot population in Lake Constance bears the genetic signature of both contemporary gene flow and historical separation events.
An Interior Point Method for Block Angular Optimization

An interior point method for block angular optimization is developed and the convergence properties of the method are described. A major motivation for such a method is that most of the computation is easily parallelized. Computational results are presented for a class of large-scale linear programming models. These models are multicommodity flow problems that arise from an Air Force (Military Airlift Command) application and generate problems as large as 100,000 rows and 300,000 columns.