Miracle-dz/UniFAR-FTUs huggingface dataset:
Patterns of Relapse in Squamous Cell Carcinoma of the Tonsil - Unilateral vs. Bilateral Radiation in the HPV-Era

Objectives: In the pre-human papillomavirus (HPV) era, unilateral radiation therapy (URT) for tonsil cancer was associated with low contralateral failure rates and had less toxicity than bilateral radiation therapy (BRT). This study explores the validity of URT in HPV-positive tonsil cancers. Methods: Tonsil squamous cell carcinomas (SCC) treated (typically with 70 Gy radiation and Cisplatin-based chemotherapy) between 2001 and 2007 were reviewed. Retrospective p16 immunohistochemistry staining was undertaken. Baseline, treatment, and response data were collected. Results: Of 182 patients, 78% were p16-positive, were younger (predominantly male), mostly former or non-smokers, and had a more advanced nodal stage. With a median follow-up of 68 months, contralateral recurrence (CLR) rates were low (3.5% p16-positive versus 2.5% p16-negative, p=0.63). Overall survival (OS) was 74% for p16-positive versus 54% for p16-negative subjects (p=0.01), but all other outcomes were similar. Analysis amongst only p16-positive subjects revealed URT was delivered to 37%, with CLR rates of 7.5% versus 1.1% for those treated with BRT, p=0.05. Of the four p16-positive subjects treated with URT who developed contralateral recurrences, three were managed with neck dissection (two disease-free and one died of lung metastases) and one received palliative radiation to the neck and distant metastatic site. All disease control and survival outcomes were similar between those treated with URT versus BRT. Conclusion: While CLRs remain rare overall, there appears to be a slightly increased rate among HPV-positive subjects treated with URT. However, overall outcomes do not appear to be impacted, suggesting that URT remains a reasonable approach in HPV-positive subjects.
International student recruitment to universities in England: discourse, rationales and globalisation

The recruitment of international students to universities in England has become a central issue in an era of globalisation for university administrators, senior managers, international offices and heads of schools and faculties. We examine the policy rationales for the recruitment of international students to England. Through the use of in‐depth interviews with key role players at four English universities, we compare the rhetoric, rationales and reasons for the recruitment of international students. A range of discourses can be identified in the recruitment of international students and an economic competition rationale is dominant. This is expressed within the discourse of globalisation.
Poly(Dimethylsiloxane) (PDMS) Affects Gene Expression in PC12 Cells Differentiating into Neuronal-Like Cells

Introduction Microfluidics systems usually consist of materials like PMMA - poly(methyl methacrylate) and PDMS - poly(dimethylsiloxane) and not polystyrene (PS), which is usually used for cell culture. Cellular and molecular responses in cells grown on PS are well characterized due to decades of accumulated research. In contrast, the experience base is limited for materials used in microfludics chip fabrication. Methods The effect of different materials (PS, PMMA and perforated PMMA with a piece of PDMS underneath) on the growth and differentiation of PC12 (adrenal phaeochromocytoma) cells into neuronal-like cells was investigated using cell viability, cell cycle distribution, morphology, and gene expression analysis. Results/Conclusions After differentiation, the morphology, viability and cell cycle distribution of PC12 cells grown on PS, PMMA with and without PDMS underneath was the same. By contrast, 41 genes showed different expression for PC12 cells differentiating on PMMA as compared to on PS. In contrast, 677 genes showed different expression on PMMA with PDMS underneath as compared with PC12 cells on PS. The differentially expressed genes are involved in neuronal cell development and function. However, there were also many markers for neuronal cell development and functions that were expressed similarly in cells differentiating on PS, PMMA and PMMA with PDMS underneath. In conclusion, it was shown that PMMA has a minor impact and PDMS a major impact on gene expression in PC12 cells.
A Study of Occupational Stressors Perceived by Hospitality and Tourism Teachers in Taiwan's Vocational Schools

ABSTRACT The purpose of this study was to investigate the potential occupational stressors for vocational school hospitality and tourism teachers in Taiwan. Data were collected via a questionnaire mailed to 649 hospitality and tourism teachers in 105 vocational schools. The response rate was 74 percent. Factor analysis was employed to identify the underlying dimensions of perceived occupational stressors, resulting in five factors: extra work besides teaching; teaching and counseling; academics and licenses; international and personal issues; and administration and contests. MANOVA and ANOVA tests were used to identify if there were differences in perceived occupational stressors by socio-demographic characteristics and organization-related attributes. The results indicated that sociodemographic characteristics and organization-related attributes played significant roles in perceived occupational stressors identified by vocational school hospitality and tourism teachers. Practical implications were suggested for vocational school hospitality and tourism teachers.
Origins and effects of group ethnocentrism and nationalism

Sumner, who coined the word, described &dquo;ethnocentrism&dquo; as &dquo;this view of things in which one’s own group is the center of everything, and all others are scaled and rated with reference to it. Each group nourishes its own pride and vanity, boasts itself superior, exalts its own divinities, and looks with contempt on outsiders. Each group thinks its own folkways the only right ones, and if it observes that other groups have other folkways, these excite its scorn&dquo;
Bladder preservation in the treatment of muscle‐invasive bladder cancer (MIBC): a review of the literature and a practical approach to therapy

Bladder preservation therapies for muscle‐invasive bladder cancer (MIBC) have been developed to address the needs of two cohorts: patients with severe medical co‐morbidities for whom radical cystectomy is too high risk and patients with limited disease who wish to avoid aggressive surgery. There are multiple bladder preservation options, although the trimodal approach of maximal transurethral resection with chemoradiotherapy is the most strongly supported. While outcomes are worse for patients unfit for surgery than those otherwise fit for surgery, bladder preservation approaches still offer curative potential.
Inhibition of Hepatitis C Virus Replication by a Specific Inhibitor of Serine-Arginine-Rich Protein Kinase

ABSTRACT Splicing of messenger RNAs is regulated by site-specific binding of members of the serine-arginine-rich (SR) protein family, and SR protein kinases (SRPK) 1 and 2 regulate overall activity of the SR proteins by phosphorylation of their RS domains. We have reported that specifically designed SRPK inhibitors suppressed effectively several DNA and RNA viruses in vitro and in vivo. Here, we show that an SRPK inhibitor, SRPIN340, suppressed in a dose-dependent fashion expression of a hepatitis C virus (HCV) subgenomic replicon and replication of the HCV-JFH1 clone in vitro. The inhibitory effects were not associated with antiproliferative or nonspecific cytotoxic effects on the host cells. Overexpression of SRPK1 or SRPK2 resulted in augmentation of HCV replication, while small interfering RNA (siRNA) knockdown of the SRPKs suppressed HCV replication significantly. Immunocytochemistry showed that SRPKs and the HCV core and NS5A proteins colocalized to some extent in the perinuclear area. Our results demonstrate that SRPKs are host factors essential for HCV replication and that functional inhibitors of these kinases may constitute a new class of antiviral agents against HCV infection.
even-skipped is not a pair-rule gene but has segmental and gap-like functions in Oncopeltus fasciatus, an intermediate germband insect

The pair-rule gene even-skipped is required for the initiation of metameric pattern in Drosophila. But Drosophila segmentation is evolutionarily derived and is not representative of most insects. Therefore, in order to shed light on the evolution of insect segmentation, homologs of the pair-rule gene even-skipped have been studied in several insect taxa. However, most of these studies have reported the expression eve but not its function. We report the isolation, expression and function of the homolog of Drosophila even-skipped from the intermediate germband insect Oncopeltus fasciatus. We find that in Oncopeltus, even-skipped striped expression initiates in a segmental and not pair-rule pattern. Weak RNAi suppression of Oncopeltus even-skipped shows no apparent pair-rule like phenotype, while stronger RNAi suppression shows deletion of nearly the entire body. These results suggest that in Oncopeltus, even-skipped is not acting as a pair-rule gene. In almost all insects, prior to its striped expression, even-skipped is expressed in a conserved broad gap-like domain but its function has been largely ignored. We find that this early broad domain is required for activation of the gap genes hunchback and Krüppel. Given the large RNAi deletion phenotype and its regulation of hunchback and Krüppel, even-skipped seems to act as an über-gap gene in Oncopeltus, indicating that it may have both upstream and downstream roles in segmentation.
A robust and efficient transmission technique for the LTE downlink

We present a new robust and efficient feedback and transmit strategy for multiuser MIMO downlink communication systems, termed Rate Approximation (RA), and analyze its performance. Using RA in combination with unitary beamforming the rate loss, due to rate-constrained feedback channel, remains bounded if the SNR increases. A lower bound on the performance of unitary beamforming with partial CSIT based on RA is given. Further, it is shown that the optimal multiuser multiplexing gain can be achieved. System level simulations demonstrate that the RA scheme outperforms other schemes discussed within LTE to enable multiuser MIMO functionalities.
Recurrent geomagnetic storms and relativistic electron enhancements in the outer magnetosphere: ISTP coordinated measurements

New, coordinated measurements from the International Solar-Terrestrial Physics (ISTP) constellation of spacecraft are presented to show the causes and effects of recurrent geomagnetic activity during recent solar minimum conditions. It is found using WIND and POLAR data that even for modest geomagnetic storms, relativistic electron fluxes are strongly and rapidly enhanced within the outer radiation zone of the Earth's magnetosphere. Solar wind data are utilized to identify the drivers of magnetospheric acceleration processes. Yohkoh solar soft X-ray data are also used to identify the solar coronal holes that produce the high-speed solar wind streams which, in turn, cause the recurrent geomagnetic activity. It is concluded that even during extremely quiet solar conditions (sunspot minimum) there are discernible coronal holes and resultant solar wind streams which can produce intense magnetospheric particle acceleration. As a practical consequence of this Sun-Earth connection, it is noted that a long-lasting E>1MeV electron event in late March 1996 appears to have contributed significantly to a major spacecraft (Anik E1) operational failure.
The paradox of strategic spatial planning: A theoretical outline with a view on Finland

Recently, the emphasis on the strategic dimension of spatial and land use planning has brought along new instruments of “soft” and informal planning. While these instruments may enhance the strategic quality of planning, more attention needs to be paid to how they relate to the existing statutory land use planning instruments. In the regulatory planning systems of continental Europe, the statutory planning instruments manifest non-strategic features, yet they cannot be ignored in strategic spatial planning. Therein lies the paradox of strategic spatial planning. The theoretical argument of the article is developed by drawing on Wilden's distinction theory that builds on the notion of logical paradox. With a view on the Finnish planning system, the article explores practical implications by utilizing Schwarz's and Healey's ideas of scenario planning and strategic framing, respectively. In so doing, the article reflects on a few cases of strategic spatial planning in Finnish city-regions, and the Finnish government's aim to develop the strategic character of statutory local master plans.
Phonological short-term and working memory in bilinguals' native and second language

ABSTRACT The goal of the current study was to examine bilinguals' phonological short-term and working memory performance in their native/first (L1) and second (L2) languages. Korean–English bilinguals were tested in both Korean (L1) and English (L2). Short-term memory (STM) was measured via a nonword repetition task, where participants repeated nonwords that increased in length. Working memory (WM) was measured via a complex task, where the nonword repetition task was combined with an animacy judgment task. In general, bilinguals performed better on the STM task than on the WM task, and with shorter nonwords than with longer nonwords. Results also revealed that L1 STM performance was superior to L2 STM performance, but only for the longest nonwords, whereas L1 WM performance was superior to L2 WM performance across all length levels. In addition, correlation analyses between bilinguals' L1 and L2 performance revealed stronger cross-linguistic associations for the WM task than for the STM task. Together, the findings suggest that WM tasks may engage domain-general central executive processes in bilinguals, whereas STM skills may depend on language-specific knowledge in the L1 and the L2.
Effect of Temperature Dependence of Magnetic Properties on Heating Characteristics of Induction Heater

In order to improve the induction heating system for an object of magnetic material, it is necessary to clarify the heating property of the object due to the eddy current loss using a magneto-thermal coupled analysis taking account of the temperature dependence of magnetic properties of a magnetic material to be heated. In this paper, the effect of temperature dependence of magnetic properties on heating characteristics of a billet heater is analyzed considering the heat emission, heat conduction and temperature dependence of magnetic properties of the billet. It is clarified that the precise analysis is possible by considering the temperature dependence of the magnetic property and the conductivity of a billet, heat emission, heat conduction etc. Moreover, the effect of temperature dependence of B-H curves on the temperature rise of a billet and the induced voltage of an exciting coil is examined.
Establishment of standardised SLA/LP immunoassays: specificity for autoimmune hepatitis, worldwide occurrence, and clinical characteristics

Background: Antibodies to soluble liver antigen/liver pancreas (SLA/LP) are specific markers of autoimmune hepatitis. Their target antigen has recently been cloned. Aims: To establish standardised immunoassays using the recombinant antigen, and to assess the frequency and significance of seropositivity in patients from different countries. Methods: An enzyme linked immunoassay was developed using purified recombinant antigen and validated by testing sera from 200 healthy blood donors and 1026 patients with various liver and non-liver diseases. The assay was then applied to 454 sera from 419 patients with autoimmune hepatitis from different countries. All sera were also tested by inhibition immunoassay and western blot. Results: Antibodies were reliably detected by the recombinant immunoassay and occurred exclusively in patients with autoimmune liver disease. Twenty three of 149 patients from the USA (15%), 23/132 from Brazil (17%), 21/108 from Germany (19%), and 2/30 from Japan (7%) were seropositive. Clinical features at presentation were similar between seropositive and seronegative patients. However, relapse after corticosteroid withdrawal or during maintenance therapy occurred more commonly in seropositive patients. Conclusions: Antibodies to SLA/LP can be reliably detected by these standardised immunoassays based on recombinant antigen. Antibodies to SLA/LP occur with similar frequencies in different geographical regions, races, and age groups, and are of exquisite diagnostic specificity. Whether SLA/LP positive patients represent a clinically distinct subgroup remains to be determined; relapse during treatment reduction appeared to be more common in the SLA/LP group.
Prospective clinical study of autologous chondrocyte implantation and correlation with MRI at three and 12 months

©2003 British Editorial Society of Bone and Joint Surgery doi:10.1302/0301-620X.85B7. 13782 $2.00 n order to determine the usefulness of MRI in assessing autologous chondrocyte implantation (ACI) the first 57 patients (81 chondral lesions) with a 12month review were evaluated clinically and with specialised MRI at three and 12 months. Improvement 12 months after operation was found subjectively (37.6 to 51.9) and in knee function levels (from 85% International Cartilage Repair Society (ICRS) III/IV to 61% I/II). The International Knee Documentation Committee (IKDC) scores showed an initial deterioration at three months (56% IKDC A/B) but marked improvement at 12 months (88% A/B). The MRI at three months showed 82% of patients with at least 50% defect fill, 59% with a normal or nearly normal signal at repair sites, 71% with a mild or no effusion and 80% with a mild or no underlying bonemarrow oedema. These improved at 12 months to 93%, 93%, 94% and 91%, respectively. The overall MR score at 12 months suggested production of normal or nearly normal cartilage in 82%, corresponding to a subjective improvement in 81% of patients and 88% IKDC A/B scores. Second-look surgery and biopsies in 15 patients (22 lesions) showed a moderate correlation of MRI with visual scoring; 70% of biopsies showed hyaline and hyaline-like cartilage. Thus, MRI at 12 months is a reasonable non-invasive means of assessment of ACI.
Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration

Cdc42 is believed to play an important role in controlling the polarity of migrating cells, but it has not been possible to directly determine the effects of localized Cdc42 activity. Optogenetic activation of Cdc42 at one side of the cell was used to identify local and distal signaling responses that contribute to directed cell migration.
The HCR-20 Violence Risk Assessment Scheme

The Historical, Clinical, and Risk Management (HCR-20) violence risk assessment scheme was coded in a sample of 75 Canadian male, federally sentenced, maximum-security offenders. The concurrent validity of the HCR-20 was assessed through comparison to other risk instruments and to the presence of several past indexes of violent and antisocial behavior. The HCR-20 showed moderate to strong relationships with the concurrent measures. The HCR-20 was as or more strongly related to past violence than were the Psychopathy Checklist—Revised or the Violence Risk Appraisal Guide. Scores above the median of the HCR-20 increased the odds of the presence of various measures of past violence and antisocial behavior by an average of four times. Although recognizing the limitations of a small sample and retrospective design, the results give some indication that the HCR-20 may be worth investigating as a useful tool for violence risk assessments in correctional samples.
The Effect of Emergent Strategies on Alignment

A feature of our research into IS/business alignment is the emphasis by participants on the importance of relationships in alignment but, at the same time, their almost total ignorance of strategy. Focus has since been directed towards strategy development and enactment within organizations. A number of issues important for ISlbusiness alignment research were uncovered. Firstly, strategies that tend to be enacted within organizations have certain characteristics. These characteristics tend to be present in the informal strategies that are never documented but tend to be absent informal strategies. Secondly, there appears to be no guarantee that the strategies that are enacted within an organization are directed toward its well-being. This makes us believe that research and practices that emphasizes the integration of formal business and information systems plans may not be particularly useful. Alignment must consider both the formal and informal strategies that exist simultaneously within an organization. Together, these support the call by previous authors for more emphasis on the social dimension of alignment.
Public Capital Spillovers and Growth Revisited: A Long-Run and Dynamic Structural Analysis

We extend the deterministic growth model of Glomm and Ravikumar (1994) to a stochastic endogenous growth model which nests both exogenous and endogenous growth factors. By introducing simple shocks to production technology, private capital and public capital investment, we can derive testable time series properties of the analytical model. We find evidence of co-integration between per capita output, per capita private capital and public capital. A nested test of the strictly endogenous growth model is rejected statistically. We find that growth is exogenous even in the presence of significant and sizeable public capital spillover effects. Our long-run elasticity estimates help to inform the short-run dynamic transitions of the model. In particular, we are able to structurally rationalise other empirical findings of bi-directional short-run effects between public and private capital and also aggregate output.
STUDIES OF THE CENTER OF GRAVITY IN THE HUMAN BODY

The position of the center of gravity in the human body has been studied from various points of view by anatomists and physiologists for many years. The earlier investigators were primarily concerned with the theoretical significance of locating the center of mass of the body. Later workers have emphasized the importance of considering the effects of gravity in problems of the mechanics of posture and locomotion. More recently the center of gravity of the human fetus has been studied in connectionwith certain obstetrical problems. At various times the situation of the center of gravity has been considered an important factor in the estimation of various types of body build and body form. Although extensive studies have been made on the position of the center of mass of the human body, no adequate method has been described for the finding of this point and most of the studies have been based upon analysis of very few observations. It was the aim of this research to develop an accurate and expedient method for the determination of the center of gravity in the living body and to apply this method to a sufficiently large series of cases to permit a statistical analysis of some of the more important influences which the force of gravity may have on the human body. It is believed that a study of this kind may throw some light upon various problems of the growth of the body and in particular to be of importance in connection with certain problems of the mechanics of child physiology as applied to motor activity and motor coordination. It is the purpose of the present paper to show detailed determinations of the