Miracle-dz/UniFAR-FTUs huggingface dataset:
Hearing screening in a neonatal intensive care unit.

OBJECTIVE Investigate the prevalence of hearing impairment in newborns hospitalized at the Intensive and Intermediate Care Unit at the Women's Comprehensive Health Center Neonatology Service (UNICAMP) and associated risk factors. METHODS 979 newborn babies were assessed between January 2000 and January 2003, through automated auditory brainstem response (AABR) (ALGO 2e color screener). The result was considered normal when the newborn showed response to a 35dBNA signal bilaterally. The prevalence of AABR impairment and the odds ratio were analyzed with a 95% confidence interval using bivariate analysis. To identify the independent risk factors for hearing alterations, multivariate analyses were used with logistic regression. RESULTS The prevalence of AABR impairment was 10.2%, of which 5.3% was unilateral and 4.9% bilateral. From the multivariate analyses, the following observations were made: family history of congenital hearing loss (OR = 5.192; p = 0.016), craniofacial deformity (OR = 5.530; p < 0.001), genetic syndromes associated with hearing loss (OR = 4.212; p < 0.001), weight below 1,000 g (OR = 3.230; p < 0.001), asphyxia (OR = 3.532; p < 0.001), hyperbilirubinemia (OR = 4.099; p = 0.002) and use of mechanical ventilation (OR = 1.826; p < 0.031) were the indicators that best characterized the group at risk for hearing impairment. CONCLUSIONS The prevalence of hearing impairment using AABR is high. Therefore, it is essential for all newborns who present isolated or associated risk factors to undergo hearing screening in situations in which it is not possible to have universal hearing screening.
Adsorption of surfactant protein D from human respiratory secretions by carbon nanotubes and polystyrene nanoparticles depends on nanomaterial surface modification and size

The alveolar respiratory unit constitutes one of the main targets of inhaled nanoparticles; the effect of engineered nanomaterials (NMs) on human health is largely unknown. Surfactant protein D (SP-D) is synthesized by alveolar type II epithelial cells and released into respiratory secretions; its main function is in immune defence, notably against inhaled microbes. SP-D also plays an important role in modulating an appropriate inflammatory response in the lung, and reduced SP-D is associated with a number of inflammatory lung diseases. Adsorption of SP-D to inhaled NMs may facilitate their removal via macrophage phagocytosis. This study addresses the hypothesis that the chemistry, size and surface modification of engineered NMs will impact on their interaction with, and adsorption of, SP-D. To this purpose, we have examined the interactions between SP-D in human lung lavage and two NMs, carbon nanotubes and polystyrene nanoparticles, with different surface functionalization. We have demonstrated that particle size, functionalization and concentration affect the adsorption of SP-D from human lung lavage. Functionalization with negatively charged groups enhanced the amount of SP-D binding. While SP-D binding would be expected to enhance macrophage phagocytosis, these results suggest that the degree of binding is markedly affected by the physicochemistry of the NM and that deposition of high levels of some nanoparticles within the alveolar unit might deplete SP-D levels and affect alveolar immune defence mechanisms.
Traffic causality graphs: Profiling network applications through temporal and spatial causality of flows

Traffic causality graphs (TCGs) are proposed for visualizing and analyzing the temporal and spatial causality of flows to profile network applications without inspecting packet payload. A key idea of TCGs is to focus on the causality of individual flows composed of different application protocols rather than a set of host flows. This idea enables us to analyze temporal interactions between flows, such as the temporal manner of flow generation by identical application programs and interactions between incoming and outgoing flows. We demonstrate the effectiveness of TCGs for profiling network applications in case studies with ground truth datasets. The results show that the simple features of TCGs are discriminative for profiling network applications and that TCGs are also advantageous for profiling application programs, such as user agents of Web browsers and proxies that cannot be classified by existing approaches; this enables us to identify a specific application program that uses the same protocol as other programs. In addition to the TCG features, the visualization of TCGs reveals the causality of each flow, which consequently helps network operators to identify the root causes of other flows, such as malicious ones.
Trends in Roll-Your-Own Smoking: Findings from the ITC Four-Country Survey (2002–2008)

Objective. To establish the trends in prevalence, and correlates, of roll-your-own (RYO) use in Canada, USA, UK and Australia, 2002–2008. Methods. Participants were 19,456 cigarette smokers interviewed during the longitudinal International Tobacco Control (ITC) Four-Country Survey in Canada, USA, UK, and Australia. Results. “Predominant” RYO use (i.e., >50% of cigarettes smoked) increased significantly in the UK and USA as a proportion of all cigarette use (both P < .001) and in all countries as a proportion of any RYO use (all P < .010). Younger, financially stressed smokers are disproportionately contributing to “some” use (i.e., ≤50% of cigarettes smoked). Relative cost was the major reason given for using RYO, and predominant RYO use is consistently and significantly associated with low income. Conclusions. RYO market trends reflect the price advantages accruing to RYO (a product of favourable taxation regimes in some jurisdictions reinforced by the enhanced control over the amount of tobacco used), especially following the impact of the Global Financial Crisis; the availability of competing low-cost alternatives to RYO; accessibility of duty-free RYO tobacco; and tobacco industry niche marketing strategies. If policy makers want to ensure that the RYO option does not inhibit the fight to end the tobacco epidemic, especially amongst the disadvantaged, they need to reduce the price advantage, target additional health messages at (young) RYO users, and challenge niche marketing of RYO by the industry.
On Local Solutions of the Celis--Dennis--Tapia Subproblem

We discuss the distribution of the local solutions of the Celis--Dennis--Tapia (CDT) subproblem, which appears in some trust region algorithms for nonlinear optimization. We also give some examples to show the differences between the CDT subproblem and the single-ball-constraint subproblem. These results show that the complexity of the CDT subproblem does not depend on the complexity of the structure of the dual plane. Thus they provide the possibility to search for the global minimizer in the dual plane.
INFLUENCE OF CELL SIZE AND CELL WALL VOLUME FRACTION ON FAILURE PROPERTIES OF POTATO AND CARROT TISSUE

This article presents the influence of cell size and cell wall volume fraction on the failure parameters of potato tuber and carrot tissue. Confocal scanning laser microscope was used for obtaining images of the cell structure of the tissues. The mean cell face area and the cell wall volume fraction obtained from the images was compared with work to failure, failure stress, failure strain and secant modulus obtained in a compression test of potato and carrot tissue at two strain rates. Bigger cells and less amount of cell wall material weakened the tissue, which was visible as a linear decrease in the parameters: work to failure, failure stress and failure strain. There were differences between potato and carrot in the secant modulus. For carrot, the secant modulus changed with microstructural parameters, whereas for potato, the secant modulus did not depend on these values. The strain rate decreases all the failure properties for potato. For carrot, only the work to failure was affected by the strain rate.
High voluntary alcohol consumption, in experimental liver cirrhosis is hardly responsive to opioid antagonist treatment.

BACKGROUND Rats with liver cirrhosis, evoked by chronic administration of thioacetamide (TAA), consumed voluntarily more alcohol than their healthy counterparts. Seeking the mechanisms underlying this phenomenon, the opioid system was screened for involvement and alterations. In vivo, the influence of chronically administered Naloxone and Naltrexone, non-specific opioid receptor antagonists, on alcohol intake was examined in free choice tests between 10% alcohol and tap water and ex vivo receptor binding studies were performed on cerebral membrane preparations. METHODS TAA rats, selected for the study, had confirmed liver insufficiency: their plasma bilirubin concentrations were about 3 times higher, the prothrombin time was 50% longer and they consumed voluntarily 3 times more alcohol than the control animals. The drugs were given s.c. for five days, at the beginning of the dark phase of a 24h cycle, in a daily dose of 10 mg per kg body mass. Throughout the treatment, the rats were kept individually in metabolic cages with a free access to water, alcohol solution and food. Feed and fluid consumption, as well as the urine outputs, were recorded on the 2h, 4h, 6h and 24h after the drug administration. The mu opioid ligand - [(3)H]-(D-Ala(2), -N-MePhe(4), Glyol(5)) Enkephalin was used to obtain binding characteristics of the control and TAA rat brain membranes. RESULTS The drugs, if modified drinking behaviours, they did it transiently; alcohol, water and thus the total fluid intake by the cirrhotic and control rats was significantly less after 2h - 6h from either naloxone or naltrexone administration. Both drugs decreased general fluid consumption as such rather than the consumption of alcohol only, as observed from the recordings related to TAA rats. The binding data: K(d) of 2.62 +/- 0.98 nM and B(max) of 43.71 +/- 6.12 fmol/mg protein for cirrhotic rats, versus K(d) of 4.63 +/- 1.98 nM and B(max) 95.61 +/- 18.33 fmol/mg protein for the control ones, suggest that while the affinity of radioligand to cerebral mu receptors was similar for the two groups, there was a lower density of those receptors in the cirrhotic rats. CONCLUSIONS The results indicate some disturbances in the opioid system in cirrhotic rats. However, the low response to opioid therapy suggests that the opioid system may have only be partly involved in the development of the observed increased alcohol drinking in the rats with liver cirrhosis.
Collective First-Person Vision for Automatic Gaze Analysis in Multiparty Conversations

This paper targets smallto medium-sized-group face-to-face conversations where each person wears a dual-view camera, consisting of inwardand outward-looking cameras, and presents an almost fully automatic but accurate ofline gaze analysis framework that does not require users to perform any calibration steps. Our collective first-person vision framework, where captured audio-visual signals are gathered and processed in a centralized system, jointly undertakes the fundamental functions required for group gaze analysis, including speaker detection, face tracking, and gaze tracking. Of particular note is our self-calibration of gaze trackers by exploiting a general conversation rule, namely that listeners are likely to look at the speaker. From the rough conversational prior knowledge, our system visualizes fine-grained participants' gaze behavior as a gazee-centered heat map, which quantitatively reveals what parts of the gazee's body the participant looked at and for how long while the gazer was speaking or listening. An experiment using conversations amounting to a total of 140 min, each lasting an average of 8.7 min and engaged in by 37 participants in groups of three to six, achieves a mean absolute error of 2.8° in gaze tracking. A statistical test reveals neither a group size effect nor a conversation type effect. Our method achieves F-scores of over 0.89 and 0.87 in gazee and eye contact recognition, respectively, in comparison with human annotation.
An inertial sensor system for measurements of tibia angle with applications to knee valgus/varus detection

Accurate measurement of knee motion during dynamic movements is the key to detect and highlight deficiencies in peripheral muscles and ligaments of the knee and hence to predict the risk of injury. Miniature inertial sensors are increasingly becoming a viable option for human movement measurement, given their small size, low cost and relatively good accuracy compared with traditional optical measurements. A system capable of measuring tibia angle using a shank mounted wireless inertial sensor is proposed. The system employs a simple setup with only one skin-mounted triaxial accelerometer and gyroscope module attached to the tibia segment, and an algorithm to estimate the tibia angle. The accuracy of the system was assessed by an optical tracking system (Optotrak Certus) during dynamic movements performed by three subjects by evaluating Root-Mean-Square Error (RMSE) of tibia-flexion and tibia-adduction angles over the period of motion. We achieve an RMSE of 1.6±1.1 and2.5±1.6 degrees in tibia-flexion and tibia-adduction angles, respectively. It is argued that tibia angle can be reliably used to detect valgus or varus movement of the knee and hence the proposed system provides a simple and useful assessment tool for performance enhancement and rehabilitation.
Cross-lingual Dataless Classification for Languages with Small Wikipedia Presence

This paper presents an approach to classify documents in any language into an English topical label space, without any text categorization training data. The approach, Cross-Lingual Dataless Document Classification (CLDDC) relies on mapping the English labels or short category description into a Wikipedia-based semantic representation, and on the use of the target language Wikipedia. Consequently, performance could suffer when Wikipedia in the target language is small. In this paper, we focus on languages with small Wikipedias, (Small-Wikipedia languages, SWLs). We use a word-level dictionary to convert documents in a SWL to a large-Wikipedia language (LWLs), and then perform CLDDC based on the LWL's Wikipedia. This approach can be applied to thousands of languages, which can be contrasted with machine translation, which is a supervision heavy approach and can be done for about 100 languages. We also develop a ranking algorithm that makes use of language similarity metrics to automatically select a good LWL, and show that this significantly improves classification of SWLs' documents, performing comparably to the best bridge possible.
The Do-Calculus Revisited

The do-calculus was developed in 1995 to facilitate the identification of causal effects in non-parametric models. The completeness proofs of [Huang and Valtorta, 2006] and [Shpitser and Pearl, 2006] and the graphical criteria of [Tian and Shpitser, 2010] have laid this identification problem to rest. Recent explorations unveil the usefulness of the do-calculus in three additional areas: mediation analysis [Pearl, 2012], transportability [Pearl and Bareinboim, 2011] and metasynthesis. Meta-synthesis (freshly coined) is the task of fusing empirical results from several diverse studies, conducted on heterogeneous populations and under different conditions, so as to synthesize an estimate of a causal relation in some target environment, potentially different from those under study. The talk surveys these results with emphasis on the challenges posed by meta-synthesis. For background material, see this http URL
The Effectiveness of Message Framing and Temporal Context on College Student Alcohol Use and Problems: A Selective E-Mail Intervention.

AIMS Only one study has examined message framing on college drinking, but did so in a laboratory setting among a general sample of college students. The current study was designed to: (a) compare the efficacy of emailed interventions differing by message framing and temporal context on alcohol involvement among heavy drinking college students and (b) examine need for cognition (NFC), consideration of future consequences (CFC) and self-efficacy as putative moderators. METHODS Hazardous drinking college students (N = 220) were randomly assigned to conditions in a 2 (Frame: gain vs. loss) × 2 (Temporal Context: long-term vs. short-term consequences) factorial design. Participants received four emails on heavy drinking consequences phrased in a manner consistent with their condition. After each message, participants were given a manipulation check. Participants were sent a 1-month follow-up assessment. Primary outcome measures were heavy episodic drinking (HED) and alcohol-related problems. We hypothesized two main effects (less alcohol consumption in the gain-frame and short-term condition), qualified by a Frame × Temporal Context interaction with substantially less alcohol involvement in the gain-frame/short-term condition. RESULTS There was very little study attrition (96.4% completed follow-up survey, 93.2-99.5% completed manipulation checks), and strong effects were observed for the manipulations. A 2 × 2 ANCOVA, controlling for baseline alcohol involvement, revealed no consistent main effects or interactions on either outcome. No moderation was observed for any putative moderator. CONCLUSIONS These results do not replicate prior laboratory-based research. The null findings may be attributed to the heavy drinking sample or electronic means of message delivery.
Ethyl Linoleate Derivatives from Olefin Metathesis as a Function of the Starting Complex and Reactivity Conditions

Olefin metathesis of ethyl linoleate (EL) was investigated under different conditions of substrate amount, temperature, and catalyst. Second-generation Grubbs catalyst (G2) was used in experiments at 20 and 50 oC for 24 and 48h, whereas first-generation Grubbs catalyst (G1) and [RuCl2(PPh3)2perhydroazepine] (LN) were used in experiments at 50 oC for 24h, with the latter also being investigated in the presence or absence of SnCl2 as co-catalyst. Catalytic products were analyzed for GC-MS and discussed in terms of relative percent of the metathesis products. With G2 as catalyst, GC-MS chromatograms were similar in all the amounts of EL investigated at 50 oC for 24h, except for ethyl hexadec-9-enoate (compound K), which was obtained with different percentage as a function of EL amount (55% for 2 and 5 mL and 65% for 8 mL). An α,ω-dicarboxylic acid with m/z = 444.00 (compound L) was produced from the experiments at 50 oC for 24h with similar percentage as a function of EL amount. However, the relative percentage of L changed with the increase of EL volume in the experiments at 20 oC (ca. 18, 27, and 28%, with 2, 5, and 8 mL of EL, respectively). The olefin metathesis of EL conducted by G1 reached lower selectivity than that conducted by G2 for 24h at 50 oC. Several intense peaks reached with G1 were similar to those obtained with G2, in addition to new peaks of medium intensity. Compound L showed higher m/z, similar to that presented with G2, but with lower relative proportion in the mixture. LN was inert for olefin metathesis of EL; however, it was activated in the presence of SnCl2 at 50 oC for 24h. Different compounds and selectivity as a function of the catalyst type and reaction conditions were obtained.
A chromosomal deletion map of human malformations.

Malformations are common causes of pediatric morbidity and mortality, and genetic factors are a significant component of their etiology. Autosomal deletions, in almost all cases, cause a nonspecific embryopathy that presents after birth as growth failure, mental retardation, and multiple malformations. We have constructed a chromosome map of autosomal deletions associated with 47 different congenital malformations, using detailed clinical and cytogenetic information on 1,753 patients with nonmosaic single contiguous autosomal deletions. The 1,753 deletions involved 258 (89%) of 289 possible autosomal bands (by the use of ISCN 400-band nomenclature), giving a total of 4,190 deleted autosomal bands for analysis. We compared the band distributions of deletions associated with common major malformations with the distribution of all 1,753 deletions. We noted 283 positive associations between deleted bands and specific malformations, of which 199 were significant (P<.05, P>.001) and 84 were highly significant (P<.001). These "malformation-associated bands" (MABs) were distributed among 137 malformation-associated chromosome regions (MACRs). An average of 6 MABs in 2.9 MACRs were detected per malformation studied; 18 (6%) of 283 MABs contain a locus known to be associated with the particular malformation. A further 18 (6%) of 283 are in seven recognized specific malformation-associated aneuploid regions. Therefore, 36 (26%) of 137 of the MACRs contain an MAB coinciding with a previously recognized locus or malformation-associated aneuploid region. This map should facilitate identification of genes important in human development.
Assessment of audio features for automatic cough detection

This paper addresses the issue of cough detection using only audio recordings, with the ultimate goal of quantifying and qualifying the degree of pathology for patients suffering from respiratory diseases, notably mucoviscidosis. A large set of audio features describing various aspects of the audio signal is proposed. These features are assessed in two steps. First, their intrisic potential and redundancy are evaluated using mutual information-based measures. Secondly, their efficiency is confirmed relying on three classifiers: Artificial Neural Network, Gaussian Mixture Model and Support Vector Machine. The influence of both the feature dimension and the classifier complexity are also investigated.
Electrostatic Interactions Involving the Extreme C Terminus of Nuclear Export Factor CRM1 Modulate Its Affinity for Cargo*

The toroid-shaped nuclear protein export factor CRM1 is constructed from 21 tandem HEAT repeats, each of which contains an inner (B) and outer (A) α-helix joined by loops. Proteins targeted for export have a nuclear export signal (NES) that binds between the A-helices of HEAT repeats 11 and 12 on the outer surface of CRM1. RanGTP binding increases the affinity of CRM1 for NESs. In the absence of RanGTP, the CRM1 C-terminal helix, together with the HEAT repeat 9 loop, modulates its affinity for NESs. Here we show that there is an electrostatic interaction between acidic residues at the extreme distal tip of the C-terminal helix and basic residues on the HEAT repeat 12 B-helix that lies on the inner surface of CRM1 beneath the NES binding site. Small angle x-ray scattering indicates that the increased affinity for NESs generated by mutations in the C-terminal helix is not associated with large scale changes in CRM1 conformation, consistent with the modulation of NES affinity being mediated by a local change in CRM1 near the NES binding site. These data also suggest that in the absence of RanGTP, the C-terminal helix lies across the CRM1 toroid in a position similar to that seen in the CRM1-Snurportin crystal structure. By creating local changes that stabilize the NES binding site in its closed conformation and thereby reducing the affinity of CRM1 for NESs, the C-terminal helix and HEAT 9 loop facilitate release of NES-containing cargo in the cytoplasm and also inhibit their return to the nucleus.