Miracle-dz/UniFAR-FTUs huggingface dataset:
The Menstrual Cycle and Performance Feedback Alter Gender Differences in Competitive Choices

We use a within-subjects experiment with math and word tasks to show that relative performance feedback moves high-ability females toward more competitive forms of compensation, moves low-ability men toward less competitive forms, and eliminates gender differences in choices. We also examine females across the menstrual cycle and find that women in the high-hormone phase are more willing to compete than women in the low-hormone phase. There are no significant differences between choices after subjects receive feedback. Thus, biological differences lead to economically significant differences, but the impact of those differences can be lowered through relative performance information.
Arterial hypoxaemia: a side-effect of intravenous isoprenaline used after cardiac surgery.

Intravenous administration of isoprenaline following cardiac surgery has been shown to cause an increase in existing arterial hypoxaemia. This is considered to be due to an increase in venous admixture following interference with the normal compensatory mechanism which in the presence of alveolar hypoxia tends to maintain normal ventilation-perfusion relationships.
Helicobacter suis Causes Severe Gastric Pathology in Mouse and Mongolian Gerbil Models of Human Gastric Disease

Background “Helicobacter (H.) heilmannii” type 1 is the most prevalent gastric non-H. pylori Helicobacter species in humans suffering from gastric disease. It has been shown to be identical to H. suis, a bacterium which is mainly associated with pigs. To obtain better insights into the long-term pathogenesis of infections with this micro-organism, experimental infections were carried out in different rodent models. Methodology/Principal Findings Mongolian gerbils and mice of two strains (BALB/c and C57BL/6) were infected with H. suis and sacrificed at 3 weeks, 9 weeks and 8 months after infection. Gastric tissue samples were collected for PCR analysis, histological and ultrastructural examination. In gerbils, bacteria mainly colonized the antrum and a narrow zone in the fundus near the forestomach/stomach transition zone. In both mice strains, bacteria colonized the entire glandular stomach. Colonization with H. suis was associated with necrosis of parietal cells in all three animal strains. From 9 weeks after infection onwards, an increased proliferation rate of mucosal epithelial cells was detected in the stomach regions colonized with H. suis. Most gerbils showed a marked lymphocytic infiltration in the antrum and in the forestomach/stomach transition zone, becoming more pronounced in the course of time. At 8 months post infection, severe destruction of the normal antral architecture at the inflamed sites and development of mucosa-associated lymphoid tissue (MALT) lymphoma-like lesions were observed in some gerbils. In mice, the inflammatory response was less pronounced than in gerbils, consisting mainly of mononuclear cell infiltration and being most severe in the fundus. Conclusions/Significance H. suis causes death of parietal cells, epithelial cell hyperproliferation and severe inflammation in mice and Mongolian gerbil models of human gastric disease. Moreover, MALT lymphoma-like lesions were induced in H. suis-infected Mongolian gerbils. Therefore, the possible involvement of this micro-organism in human gastric disease should not be neglected.
The New Zealand rugby injury and performance project. IV. Anthropometric and physical performance comparisons between positional categories of senior A rugby players.

OBJECTIVE--To describe the anthropometric and physical performance characteristics of a sample of senior A club rugby players and to highlight differences between the positional categories of the players within the forwards and backs. METHODS--94 senior A male rugby players were assessed on a number of anthropometric and physical performance assessments. The forwards were categorised into props, hookers, locks, and loose forwards. Backs were categorised into inside, midfield, and outside backs. Categories within the forwards were compared with each other, as were the categories within the backs. RESULTS--The anthropometric characteristics of forwards differed significantly between positional categories. Front row forwards (props and hookers) possessed highly endo-mesomorphic somatotypes, and typically rated very low for ectomorphy. Props possessed greater body mass than hookers. Locks and loose forwards were taller than the front row forwards. In terms of physical performance fewer differences were observed. Hookers performed better than props on an aerobic assessment. Locks and loose forwards were faster than the front row forwards on a 30 m sprint from a running start. The inside backs were shorter and lighter than the midfield and outside backs. CONCLUSIONS--The combination of anthropometric characteristics and physical performance attributes observed allows players to best meet the demands imposed on them by their position.
Role of Peptidergic Nerve Terminals in the Skin: Reversal of Thermal Sensation by Calcitonin Gene-Related Peptide in TRPV1-Depleted Neuropathy

To investigate the contribution of peptidergic intraepidermal nerve fibers (IENFs) to nociceptive responses after depletion of the thermal-sensitive receptor, transient receptor potential vanilloid subtype 1 (TRPV1), we took advantage of a resiniferatoxin (RTX)-induced neuropathy which specifically affected small-diameter dorsal root ganglion (DRG) neurons and their corresponding nerve terminals in the skin. Thermal hypoalgesia (p<0.001) developed from RTX-treatment day 7 (RTXd7) and became normalized from RTXd56 to RTXd84. Substance P (SP)(+) and TRPV1(+) neurons were completely depleted (p = 0.0001 and p<0.0001, respectively), but RTX had a relatively minor effect on calcitonin gene-related peptide (CGRP)(+) neurons (p = 0.029). Accordingly, SP(+) (p<0.0001) and TRPV1(+) (p = 0.0008) IENFs were permanently depleted, but CGRP(+) IENFs (p = 0.012) were only transiently reduced and had recovered by RTXd84 (p = 0.83). The different effects of RTX on peptidergic neurons were attributed to the higher co-localization ratio of TRPV1/SP than of TRPV1/CGRP (p = 0.029). Thermal hypoalgesia (p = 0.0018) reappeared with an intraplantar injection of botulinum toxin type A (botox), and the temporal course of withdrawal latencies in the hot-plate test paralleled the innervation of CGRP(+) IENFs (p = 0.0003) and CGRP contents in skin (p = 0.01). In summary, this study demonstrated the preferential effects of RTX on depletion of SP(+) IENFs which caused thermal hypoalgesia. In contrast, the skin was reinnervated by CGRP(+) IENFs, which resulted in a normalization of nociceptive functions.
Molecular Dynamics Simulation of HIV Fusion Inhibitor T-1249: Insights on Peptide-Lipid Interaction

T-1249 is a peptide that inhibits the fusion of HIV envelope with the target cell membrane. Recent results indicate that T-1249, as in the case of related inhibitor peptide T-20 (enfuvirtide), interacts with membranes, more extensively in the bilayer liquid disordered phase than in the liquid ordered state, which could be linked to its effectiveness. Extensive molecular dynamics simulations (100 ns) were carried out to investigate the interaction between T-1249 and bilayers of 1-palmitoyl-2-oleoyl-phosphatidylcholine (POPC) and POPC/cholesterol (1 : 1). It was observed that T-1249 interacts to different extents with both membrane systems and that peptide interaction with the bilayer surface has a local effect on membrane structure. Formation of hydrogen bonding between certain peptide residues and several acceptor and donor groups in the bilayer molecules was observed. T-1249 showed higher extent of interaction with bilayers when compared to T-20. This is most notable in POPC/Chol membranes, owing to more peptide residues acting as H bond donors and acceptors between the peptide and the bilayer lipids, including H-bonds formed with cholesterol. This behavior is at variance with that of T-20, which forms no H bonds with cholesterol. This higher ability to interact with membranes is probably correlated with its higher inhibitory efficiency.
Complex mental and physical activity in older women and cognitive performance: a 6-month randomized controlled trial.

BACKGROUND Several reports suggest beneficial impacts of either physical or mental activity on cognitive function in old age. However, the differential effects of complex mental and physical activities on cognitive performance in humans remain to be clarified. METHODS This randomized controlled trial evaluates a cognitive and a physical standardized 6-month activity intervention (3 x 1.5 h/wk) conducted in Berlin (Germany). Two hundred fifty nine healthy women aged 70-93 years were randomized to a computer course (n = 92), an exercise course (n = 91), or a control group (n = 76), of whom 230 completed the 6-month assessment. Group differences in change over a period of 6 months in episodic memory (story recall, possible range, 0-21; word recall, possible range, 0-16), executive control (working memory, ie, time quotient of Trail Making Tests B/A), and verbal fluency were evaluated by analyses of covariance (intention to treat) adjusting for baseline, fluid intelligence, and educational level. RESULTS In contrast to the control group, both the exercise group, DeltaM (SD) = 2.09 (2.66), p < . 001, and the computer group, DeltaM (SD) =1.89 (2.88), p < . 001, showed improved delayed story recall. They maintained performance in delayed word recall and working memory (time measure) as opposed to the control group that showed a decline, DeltaM (SD) = -0.91 (2.15), p = . 001, and DeltaM (SD) = 0.24 (0.68), p = . 04, respectively. CONCLUSIONS In healthy older women, participation in new stimulating activities contributes to cognitive fitness and might delay cognitive decline. Exercise and computer classes seem to generate equivalent beneficial effects.
Environmental Ethics: Anthropocentrism and Non-anthropocentrism Revised in the Light of Critical Realism

ABSTRACT Some eco-philosophers argue that our responsibilities to the natural world are only indirect, that the responsibility to preserve nature or resources, for example, is best understood with respect to the responsibilities that we owe to other humans. Anthropocentric ethics holds that only human beings have moral value. Thus, although we may be said to have responsibilities regarding the natural world, we do not have direct responsibilities to the natural world. As a reaction to anthropocentrism, other eco-philosophers disagree, however, saying that we have direct responsibilities to natural objects other than human beings. Non-anthropocentric ethics grants moral standing to such natural objects as animals, plants and landscapes. Non-anthropocentrism requires an extension and revision of standard ethical principles. My main point in this article is twofold. First, I want to show that there is a serious flaw in anthropocentrism; my argument is that most anthropocentric approaches are based on either a particular scientific and reductionist worldview or a constructivist worldview, neither of which is adequate. Hence the anthropocentrism that follows from these worldviews is inadequate too. Secondly, I claim that most non-anthropocentric approaches are also inadequate in the sense that they are based on anthropocentrism at arm’s length or a disguised anthropocentrism; that is, they are equally scientistic and reductionist, even if by different means. By tracing Bhaskar’s philosophy from basic critical realism to dialectical critical realism and metaReality, relying specifically on Seo MinGyu’s interpretation, I will develop an alternative critical realist non-anthropism and anti-reductionism. By then engaging with Terrence Deacon’s contrasting dynamic systems perspective, which I take to be in line with Bhaskar’s thought, I want to show what is wrong with existing anthropocentric and non-anthropocentric approaches.
Compartmentalized and Signal-Selective Gap Junctional Coupling in the Hearing Cochlea

Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric configuration. We investigated the functional and structural properties of native cochlear gap junctions in rats, from birth to the onset of hearing [postnatal day 12 (P12)[. Confocal immunofluorescence revealed increasing Cx26 and Cx30 expression from P0 to P12. Functional GJIC was assessed by coinjection of Lucifer yellow (LY) and Neurobiotin (NBN) during whole-cell recordings in cochlear slices. At P0, there was restricted dye transfer between supporting cells around outer hair cells. Transfer was more extensive between supporting cells around inner hair cells. At P8, there was extensive transfer of both dyes between all supporting cell types. By P12, LY no longer transferred between the supporting cells immediately adjacent to hair cells but still transferred between more peripheral cells. NBN transferred freely, but it did not transfer between inner and outer pillar cells. Freeze fracture further demonstrated decreasing GJIC between inner and outer pillar cells around the onset of hearing. These data are supportive of the appearance of signal-selective gap junctions around the onset of hearing, with specific properties required to support auditory function. Furthermore, they suggest that separate medial and lateral buffering compartments exist in the hearing cochlea, which are individually dedicated to the homeostasis of inner hair cells and outer hair cells.
Semi Mature Blood Dendritic Cells Exist in Patients with Ductal Pancreatic Adenocarcinoma Owing to Inflammatory Factors Released from the Tumor

Background Much evidence exists regarding the fact that blood DCs, both myeloid DCs (MDCs) and plasmacytoid DCs (PDCs), are negatively affected in different types of cancer, with both reduced numbers and impaired functionality. Functional impairment of DCs in patients with pancreatic ductal adenocarcinoma (PDAC), may contribute to the poor clinical outcome. The aim of this study was to examine the effects PDAC had on blood DCs and elucidate the underlying mechanism responsible for the DC impairment. Methodology/Principal Findings We examined the systemic influence PDAC exerted on blood DCs by ex vivo measuring numerous activation and maturation markers expressed on these cells. Furthermore, the effect patient plasma and the inflammatory factors CXCL8 and PGE2 had on purified MDCs and PDCs from healthy donors was assessed and compared to the DCs existing in PDAC patients. We found a partial maturation of the blood MDCs and PDCs in PDAC patients with significantly enhanced expression of CD83, CD40, B7H3, PDL-1, CCR6, and CCR7 and decreased expression of ICOSL, and DCIR. These changes lead to impairment in their immunostimulatory function. Furthermore, chronic pancreatitis gave rise to DCs with similar semi-mature phenotype as seen in PDAC. Low expression of ICOSL was associated with poor prognosis. We found that the mechanism underlying this semi-maturation of DCs was inflammatory factors existing in the PDAC patients' plasma. Of note, PGE2, which is elevated PDAC patient plasma, was one contributing factor to the changes seen in MDCs and PDCs phenotype. Conclusion/Significance Our findings point to a role for the systemic inflammation in transforming blood MDCs and PDCs into semi-mature cells in PDAC patients and we show a correlation between maturation status and clinical outcome. Thus, means to preserve a functional blood DC compartment in PDAC patients by diminishing the inflammation could facilitate their ability to control the disease and improve survival.
The cingulate cortex and human memory processes

This study presents data from a magnetic-resonance morphometric (MRMM) analysis of the main regions of the cingulate cortex (in both hemispheres) and their role in memory processes in a group of healthy, females of older age. The results demonstrate a statistically reliable correlation between overall performance and the type of errors in different neuropsychological memory tests and the relative size of these regions. The discovered pattern of correlations can be explained by hypothesizing the reciprocal functional influence of the two major areas of the cingulate cortex – its anterior and posterior dorsal parts – on performance in neuropsychological memory tests.
What Happened in Palm Beach County ?

It is now well-known that the design of the ballot in Palm Beach County could have led to numerous mistakes in voting. Moreover, it is easy to show that the Buchanan vote in Palm Beach County is a substantial outlier considering the Bush and Gore votes in that county. Buchanan obtained about . 8% of the vote, but his expected vote was probably no more than . 2% to . 3%. Indeed, statewide, Buchanan received about . 3% of the three candidate (Bush, Gore, and Buchanan) vote. Thus, something like 2000 of Buchanan’s 3,407 votes in Palm Beach County may have been mistakes.
Occurrence, sources and transport pathways of natural and anthropogenic hydrocarbons in deep-sea sediments of the eastern Mediterranean Sea

Surface sediments collected from deep basins (1018–4087 m depth) of the eastern Mediterranean Sea (Ionian Sea, southern Aegean Sea and northwestern Levantine Sea) were analyzed for aliphatic and polycyclic aromatic hydrocarbons as tracers of natural and anthropogenic inputs. Concentrations of total aliphatic hydrocarbons, n-alkanes and the unresolved complex mixture (UCM) of aliphatic hydrocarbons varied significantly, ranging from 1.34 to 49.2 μg g −1 , 145 to 4810 ng g −1 and 0.73 to 36.7 μg g −1 , respectively, while concentrations of total polycyclic aromatic hydrocarbons (PAHs) ranged between 11.6 and 223 ng g −1 . Molecular profiles of determined hydrocarbons reflect a mixed contribution from both natural and anthropogenic sources in deep-sea sediments of the eastern Mediterranean Sea, i.e., terrestrial plant waxes, degraded petroleum products, unburned fossil fuels and combustion of grass, wood and coal. Hydrocarbon mixtures display significant variability amongst sub-regions, reflecting differences in the relative importance of inputs from various sources and phase associations/transport pathways of individual hydrocarbons that impact on their overall distribution and fate. Hydrocarbon concentrations correlated significantly with the organic carbon content of sediments, indicating that the latter exerts an important control on their transport and ultimate accumulation in deep basins. Additionally, water masses' circulation characteristics also seem to influence the regional features and distribution patterns of hydrocarbons. Our findings highlight the role of deep basins/canyons as repositories of both natural and anthropogenic chemical species.
Casting for a sovereign role: Socialising an aspirant state in the Scottish independence referendum

This article examines international reactions to Scotland’s 2014 bid for independence as an instance of socialisation of an aspirant state, what we term ‘pre-socialisation’. Building on and contributing to research on state socialisation and role theory, this study proposes a nexus between roles and sovereignty. This nexus has three components: sovereignty itself is a role casted for by an actor; the sovereign role is entangled with the substantive foreign policy roles the actor might play; and the sovereign role implicates the substantive foreign policy roles of other actors. The Scottish debate on independence provides an effective laboratory to develop and explore these theoretical dimensions of pre-socialisation, revealing the contested value and meaning of sovereignty, the possible roles that an independent Scotland could play, and the projected implications for the role of the UK and other international actors. Our analysis of the Scottish case can provide insights for other cases of pre-socialisation and is more empirically significant following the UK’s 2016 referendum to leave the European Union.
A Model Incorporating the Rationale and Purpose for Conducting Mixed-Methods Research in Special Education and Beyond

This article provides a typology ofreasons for conducting m i x ed - m et h ods re se a rch in spe cial edu c a ti o n . The mixed methods research process is described along with the role ofthe rationale and purpose ofstudy.The reasons given in the literature for utilizing mixed-methods research are explicated,and the limitations ofthese reason frameworks are identified.We build on these frameworks by providing a comprehensive list of reasons for conducting mixed-methods research.The reasons provided in our model are operationalized in the context ofspecial education and,thus,complement the goals ofspecial education re se a rch ers . Fi n a lly,we pre sent a fou r- d i m en s i o n a l Rationale and Purpose (RAP) model demonstrating how investigations can be designed according to the rationale for using mixed methods,purpose ofmixing,stage ofstudy where mixing occurs,and emphasis ofapproach derived from the research question(s).
Building classifiers with association rules based on small key itemsets

We present a simple method for building classifiers based on class-association rules. The method uses a prefix tree structure for mining the frequent itemsets and class- association rules extracted from a training dataset. The rules of a classifier are selected from those built on key item-sets with small sizes, having maximal confidences and maximal supports, and correctly classifying each object of the training dataset. The comparisons with some existing methods in classification, via the experimental results on large datasets, show that on average the present method is better in terms of accuracy and computational efficiency.
Paraphrastic neural network language models

Expressive richness in natural languages presents a significant challenge for statistical language models (LM). As multiple word sequences can represent the same underlying meaning, only modelling the observed surface word sequence can lead to poor context coverage. To handle this issue, paraphrastic LMs were previously proposed to improve the generalization of back-off n-gram LMs. Paraphrastic neural network LMs (NNLM) are investigated in this paper. Using a paraphrastic multi-level feedforward NNLM modelling both word and phrase sequences, significant error rate reductions of 1.3% absolute (8% relative) and 0.9% absolute (5.5% relative) were obtained over the baseline n-gram and NNLM systems respectively on a state-of-the-art conversational telephone speech recognition system trained on 2000 hours of audio and 545 million words of texts.
Repetitive TASER X26 Discharge Resulted in Adverse Physiologic Events with a Dose–Response Relationship Related to the Duration of Discharge in Anesthetized Swine Model

The objectives of our study were to investigate the dose–response relationship of the TASER X26 discharge duration in an anesthetized swine model. Fourteen swines were anesthetized and then exposed to TASER X26 discharge for 5 sec (n = 5) or for 10 sec (n = 6). The sham control group (n = 3) was anesthetized and studied using the same protocol except TASER X26 discharges during the experiments. Hemodynamic parameters were obtained. Blood pressure and total peripheral resistance decreased significantly after TASER discharge and returned to baseline value at 15 min after 5 sec of TASER discharge but did not return to baseline values during the 30‐min observation period after 10 sec of TASER discharge. Repetitive TASER X26 discharge resulted in adverse physiologic events with a dose–response relationship related to the duration of TASER X26 discharge in an anesthetized swine model.