Miracle-dz/UniFAR-FTUs huggingface dataset:
Discriminative density propagation for 3D human motion estimation

We describe a mixture density propagation algorithm to estimate 3D human motion in monocular video sequences based on observations encoding the appearance of image silhouettes. Our approach is discriminative rather than generative, therefore it does not require the probabilistic inversion of a predictive observation model. Instead, it uses a large human motion capture data-base and a 3D computer graphics human model in order to synthesize training pairs of typical human configurations together with their realistically rendered 2D silhouettes. These are used to directly learn to predict the conditional state distributions required for 3D body pose tracking and thus avoid using the generative 3D model for inference (the learned discriminative predictors can also be used, complementary, as importance samplers in order to improve mixing or initialize generative inference algorithms). We aim for probabilistically motivated tracking algorithms and for models that can represent complex multivalued mappings common in inverse, uncertain perception inferences. Our paper has three contributions: (1) we establish the density propagation rules for discriminative inference in continuous, temporal chain models; (2) we propose flexible algorithms for learning multimodal state distributions based on compact, conditional Bayesian mixture of experts models; and (3) we demonstrate the algorithms empirically on real and motion capture-based test sequences and compare against nearest-neighbor and regression methods.
Transport AC Loss Measurements in Single- and Two-Layer Parallel Coated Conductor Arrays With Low Turn Numbers

We measure transport ac losses in planar one-layer four-turn parallel coated conductor arrays (1 × 4) and in two-layer (2L) four-turn parallel coated conductor arrays (2 × 4) with a frequency up to 1 kHz. The horizontal separation between the conductors, i.e., gh, and the vertical separation between the neighboring superconducting layers, i.e., gv, were varied to investigate the transport ac loss dependence on gh and gv. In 2L arrays, the tapes in the top layer sit either aligned with the tapes in the bottom layer or aligned with the gaps between the tapes in the bottom layer. We show that the losses differently scale in arrays with low turn numbers to the scaling expected with an infinite array of tapes.
On Packing Densities of Permutations

The density of a permutation pattern $\pi$ in a permutation $\sigma$ is the proportion of subsequences of $\sigma$ of length $|\pi|$ that are isomorphic to $\pi$. The maximal value of the density is found for several patterns $\pi$, and asymptotic upper and lower bounds for the maximal density are found in several other cases. The results are generalised to sets of patterns and the maximum density is found for all sets of length $3$ patterns.
Toward an Understanding of the Behavioral Intention to Use a Groupware Application

INTRODUCTION Over the past decade, groupware technologies, such as e-mail, electronic bulletin boards, and group support systems, have become an important part of the business computing infrastructure in many organizations. Organizations adopt groupware applications to enhance communication and collaboration among group members and thus improve group performance. While some groupware applications, e.g., e-mail, have been commonly accepted, many other applications, especially those that require significant collaboration and cooperation among users, are not widely used in organizations and their potential benefits are far from being fully realized (Orlikowski, 1993). Although numerous laboratory and field studies have consistently shown the relevance and positive impact of group support systems on group work, more research is needed in understanding how to increase the rate of diffusion and adoption of the technology (Nunamaker, 1997). Behavioral-related elements, recognized by many, are the primary cause of resistance of users toward a newly implemented system or technology. Information technology (IT) research, however, tends to under-utilize existing knowledge in the behavioral science (Turner, 1982; Robey, 1979). Expectancy theory has been recognized as one of the most promising conceptualizations of individual motivation (Ferris, 1977). Many researchers have proposed that expectancy theory
The two-parameter Poisson–Dirichlet point process

The two-parameter Poisson–Dirichlet distribution is a probability distribution on the totality of positive decreasing sequences with sum 1 and hence considered to govern masses of a random discrete distribution. A characterization of the associated point process (that is, the random point process obtained by regarding the masses as points in the positive real line) is given in terms of the correlation functions. Using this, we apply the theory of point processes to reveal the mathematical structure of the two-parameter Poisson– Dirichlet distribution. Also, developing the Laplace transform approach due to Pitman and Yor, we are able to extend several results previously known for the one-parameter case. The Markov–Krein identity for the generalized Dirichlet process is discussed from the point of view of functional analysis based on the two-parameter Poisson–Dirichlet distribution.
Mammalian Target of Rapamycin Inhibitors Induce Tumor Cell Apoptosis In Vivo Primarily by Inhibiting VEGF Expression and Angiogenesis

We found that rapalog mTOR inhibitors induce G1 arrest in the PTEN-null HS Sultan B-cell lymphoma line in vitro, but that administration of rapalogs in a HS Sultan xenograft model resulted in significant apoptosis, and that this correlated with induction of hypoxia and inhibition of neoangiogenesis and VEGF expression. Mechanistically, rapalogs prevent cap-dependent translation, but studies have shown that cap-independent, internal ribosome entry site (IRES)-mediated translation of genes, such as c-myc and cyclin D, can provide a fail-safe mechanism that regulates tumor survival. Therefore, we tested if IRES-dependent expression of VEGF could likewise regulate sensitivity of tumor cells in vivo. To achieve this, we developed isogenic HS Sultan cell lines that ectopically express the VEGF ORF fused to the p27 IRES, an IRES sequence that is insensitive to AKT-mediated inhibition of IRES activity and effective in PTEN-null tumors. Mice challenged with p27-VEGF transfected tumor cells were more resistant to the antiangiogenic and apoptotic effects of the rapalog, temsirolimus, and active site mTOR inhibitor, pp242. Our results confirm the critical role of VEGF expression in tumors during treatment with mTOR inhibitors and underscore the importance of IRES activity as a resistance mechanism to such targeted therapy.
Fatigue Differences between Adults and Prepubertal Males

The purpose of the present study was to investigate the differences in neuromuscular activation of agonist and antagonist muscles between men and prepubertal boys during a maximal isokinetic fatigue test. Ten prepubertal boys (mean +/- SD age: 10.5 +/- 0.6 years) and fourteen adults (age: 24.3 +/- 2.5 years) executed 25 consecutive maximal isokinetic knee extensions at 60 deg . s (-1). Peak torque and the electromyogram (EMG) of the vastus lateralis, vastus medialis and biceps femoris muscles were recorded. During the fatigue protocol, the prepubertal boys were able to produce higher torque than the adults, when expressed as percent of their maximal value, indicating that adults were more fatigable. The agonist activity, especially for the vastus lateralis muscle, increased in both groups during the first 10 knee extensions, and then decreased more in adults. The antagonist activity of biceps femoris muscle in adults remained constant throughout the fatigue task, whereas the children showed, on average, an increased biceps femoris antagonistic activation, especially during the first 10 and last 5 knee extensions. These results suggest that adults are more fatigable than children during a maximal isokinetic fatigue protocol, probably due to an increased inhibition or reduced facilitation of their agonist drive.
Adoptive Transfer of Tumor-Reactive Melan-A-Specific CTL Clones in Melanoma Patients Is Followed by Increased Frequencies of Additional Melan-A-Specific T Cells1

In this study, we report the adoptive transfer of highly tumor-reactive Melan-A-specific T cell clones to patients with metastatic melanoma, and the follow-up of these injected cells. These clones were generated from HLA-A*0201 patients by in vitro stimulations of total PBMC with the HLA-A*0201-binding Melan-A peptide analog ELAGIGILTV. Ten stage IV melanoma patients were treated by infusion of these CTL clones with IL-2 and IFN-α. The generated T cell clones, of effector/memory phenotype were selected on the basis of their ability to produce IL-2 in response to HLA-A*0201 Melan-A-positive melanoma lines. Infused clones were detected, by quantitative PCR, in the blood of three patients for periods ranging from 7 to 60 days. Six patients showed regression of individual metastases or disease stabilization, and one patient experienced a complete response, but no correlation was found between the detection of the infused clones in PBMC or tumor samples and clinical responses. Nonetheless, frequencies of Melan-A/A2-specific lymphocytes, measured by tetramer labeling, increased after treatment in most patients. In one of these patients, who showed a complete response, this increase corresponded to the expansion of new clonotypes of higher avidity than those detected before treatment. Together, our results suggest that infused CTL clones may have initiated an antitumor response that may have resulted in the expansion of a Melan-A-specific CTL repertoire.
Helicobacter pylori-induced apoptosis in pathogenesis of gastric carcinoma.

BACKGROUND Despite a possible role of Helicobacter pylori in gastric carcinoma (GC), its pathogenesis is not clear. There is scanty data on apoptosis in GC in relation to H. pylori and CagA antibody. Therefore, we studied gastric epithelial apoptosis in GC and non-ulcer dyspepsia (NUD) with or without H. pylori infection, and the degree of apoptosis in relation to CagA antibody status. METHODS 20 patients each with GC and NUD were investigated for H. pylori using rapid urease test (RUT), IgG anti-H. pylori and anti-CagA antibodies, histology of endoscopically normal-looking mucosa for H. pylori, intestinal metaplasia (IM), and apoptosis using TUNEL assay. Positivity to one tissue-based (RUT or histology) and one serology based (anti-H. pylori or CagA IgG) test was taken as diagnostic of active H. pylori infection, and negative result in both tissue-based tests suggested its absence. RESULTS Patients with GC more often had anti-H. pylori IgG (16 of 20 vs. 8 of 20; p=0.02) and a trend towards higher apoptotic index (AI) (48.6 [19.2 to 71.7] vs. 41.4 [11.7 to 63.6]; p=0.06) than NUD. AI was higher in GC (66.7 [57.5 to 71.7] vs. 32.6 [19.2 to 39.8]; p<0.0001) and NUD (58.6 [50.7 to 63.6] vs. 24.4 [11.7 to 32.2]; p<0.0001) infected with H. pylori than in those without infection. AI was also higher in GC than in NUD with H. pylori infection (66.7 [57.5 to 71.7] vs. 58.6 [50.7 to 63.6]; p=0.01). Four of the 20 patients with GC and none with NUD had IM (p=ns). There was no difference in AI in relation to CagA antibody. AI positively correlated with patients' age in presence of H. pylori infection (correlation coefficient=0.5, p=0.03) but not in its absence. CONCLUSION Exaggerated apoptosis may play a role in H. pylori-mediated gastric diseases including carcinogenesis. AI increases with aging in patients infected with H. pylori.
Social Assets

We present a model incorporating both social and economic components, and analyze their interaction. The notion of a social asset, an attribute that has value only because of the social institutions governing society, is introduced. In the basic model, agents match on the basis of income and unproductive attributes. An attribute has value in some equilibrium social institutions (matching patterns), but not in others. We then show that productive attributes (such as education) can have their value increased above their inherent productive value by some social institutions, leading to the notion of the social value of an asset.
Divergence in the Expression of Molecular Markers of Neuronal Activation in the Parvocellular Paraventricular Nucleus of the Hypothalamus Evoked by Alcohol Administration via Different Routes

Immediate early gene (IEG) expression has been routinely used by neuroscientists as an index of neuronal activation. In the case of the hypothalamic–pituitary–adrenal axis, induction of c-fos and/or NGFI-B mRNAs in the parvocellular paraventricular nucleus (pPVN) has been documented after a variety of stimuli that increase adrenocorticotropin (ACTH) in the systemic circulation. However, the functional relationship between expression of IEGs and transcription of the genes for the ACTH secretagogues corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) is not clear. While investigating the neuroendocrine correlates of alcohol administration via different routes (intraperitoneal vs intragastric), we noted a difference in the time course of NGFI-B mRNA expression in the pPVN, despite comparable dynamics in ACTH secretion. By comparing the temporal cascade of transcriptional events in vivoafter alcohol injection via either route, we sought to determine functional relationships between IEGs and the induction of CRF and AVP heteronuclear RNAs (hnRNAs). One advantage of our paradigm is the use of the same stimulus (systemic alcohol injection) in which access to the CNS does not differ between the groups to be compared. Intraperitoneal administration of the drug resulted in significant increases in c-fos mRNA, Fos protein, CRF hnRNA, and AVP hnRNA. In contrast, intragastric treatment evoked a brief, modest elevation in c-fos mRNA and Fos protein, increased AVP hnRNA, and caused no detectable change in CRF hnRNA. These data indicate that robust increases in CRF hnRNA are closely linked to full expression of c-fos mRNA and Fos protein. In addition, the expression of NGFI-B after both routes of administration is indicative of cellular activation within the pPVN in parallel with secretion of ACTH.
Comparison of Genotypes and Antibiotic Resistances of Campylobacter jejuni and Campylobacter coli on Chicken Retail Meat and at Slaughter

ABSTRACT Multilocus sequence typing (MLST) and antibiotic resistance patterns of Campylobacter jejuni and Campylobacter coli from retail chicken meat showed high overlap with isolates collected at slaughterhouses, indicating little selection along the production chain. They also showed significant common sequence types with human clinical isolates, revealing chicken meat as a likely source for human infection.
Clinical epidemiology

Plasmin Modulates Sodium Retention in Nephrotic Syndrome Renal sodium retention accompanies nephrotic syndrome, but the underlying mechanisms are incompletely understood. Here, Svenningsen et al. report that urine from humans and animals with nephrosis activate the epithelial sodium channel (ENaC) and that this activation depends on the serine protease plasmin. They suggest that tubular urokinase-type plasminogen activator converts filtered plasminogen to plasmin, which in turn cleaves an inhibitory peptide from the ENaC subunit. These data provide a novel mechanism by which proteinuria leads to sodium retention via ENaC activation. See Svenningsen et al., pages 299 –310.
Anti-Ehrlichia chaffeensis antibody complexed with E. chaffeensis induces potent proinflammatory cytokine mRNA expression in human monocytes through sustained reduction of IkappaB-alpha and activation of NF-kappaB

Ehrlichia chaffeensis is an obligatory intracellular bacterium that infects monocytes and macrophages and is the etiologic agent of human ehrlichiosis in the United States. Our previous studies showed that the exposure of human monocytes to E. chaffeensis induces the expression of interleukin-1beta (IL-1beta), IL-8, and IL-10 genes in vitro but not the expression of tumor necrosis factor alpha (TNF-alpha) and IL-6 mRNAs. In this study, the effect of anti-E. chaffeensis antibody complexed with E. chaffeensis on the expression of major proinflammatory cytokines in human monocytes was examined. Human monocytic cell line THP-1 was treated with E. chaffeensis which had been preincubated with human anti-E. chaffeensis serum for 2 h, and the levels of cytokine mRNAs were evaluated by competitive reverse transcription-PCR. Anti-E. chaffeensis antibody complexed with E. chaffeensis significantly enhanced mRNA expression of IL-1beta in THP-1 cells. The expression of TNF-alpha and IL-6 mRNAs was also induced. The levels of secreted IL-1beta, TNF-alpha, and IL-6 during 24 h of stimulation were comparable to those induced by Escherichia coli lipopolysaccharide at 1 microg/ml. Fab fragment of anti-E. chaffeensis immunoglobulin G complexed with E. chaffeensis did not induce any of these three cytokines, indicating that ehrlichial binding is required for IL-1beta mRNA expression and that binding of the immune complex to the Fc gamma receptor is required for TNF-alpha and IL-6 mRNA expression and enhanced IL-1beta mRNA expression. Furthermore, prolonged degradation of IkappaB-alpha and activation of NF-kappaB were demonstrated in THP-1 cells exposed to anti-E. chaffeensis serum and E. chaffeensis. This result implies that development of anti-E. chaffeensis antibody in patients can result in the production of major proinflammatory cytokines, which may play an important role in the pathophysiology of ehrlichiosis and immune responses to it.
Diurnal Variation of Human Sweet Taste Recognition Thresholds Is Correlated With Plasma Leptin Levels

OBJECTIVE—It has recently been proposed that the peripheral taste organ is one of the targets for leptin. In lean mice, leptin selectively suppresses gustatory neural and behavioral responses to sweet compounds without affecting responses to other taste stimuli, whereas obese diabetic db/db mice with defects in leptin receptor lack this leptin suppression on sweet taste. Here, we further examined potential links between leptin and sweet taste in humans. RESEARCH DESIGN AND METHODS—A total of 91 nonobese subjects were used to determine recognition thresholds using a standard stair-case methodology for various taste stimuli. Plasma leptin levels were determined by an enzyme-linked immunosorbent assay at several timepoints during the day under normal and restricted-meal conditions. RESULTS—The recognition thresholds for sweet compounds exhibited a diurnal variation from 0800 to 2200 h that parallels variation for leptin levels, with the lowest thresholds in the morning and the highest thresholds at night. This diurnal variation is sweet-taste selective—it was not observed in thresholds for other taste stimuli (NaCl, citric acid, quinine, and mono-sodium glutamate). The diurnal variation for sweet thresholds in the normal feeding condition (three meals) was independent of meal timing and thereby blood glucose levels. Furthermore, when leptin levels were phase-shifted following imposition of one or two meals per day, the diurnal variation of thresholds for sweet taste shifted in parallel. CONCLUSIONS—This synchronization of diurnal variation in leptin levels and sweet taste recognition thresholds suggests a mechanistic connection between these two variables in humans.
Context sensitive flying interface

The requirement to change scale frequently is common to many 2D and 3D applications. Users must “zoom in” to examine details and “zoom out” to appreciate the context. This presents a problem in the context of “fly by” interfaces that use a flying metaphor to enable the user to change the point of view and explore a data space. The problem is that radical changes in velocity sensitivity may needed when working at different scrdes. A method is described that uses continous depth sampling to modulate the flying speed. The distribution of depths in the current frame of animation is used to set the Device to Control ratio so that it is always comfortable when operating over a range of scales. This is called Depth Modulated Flying (DMF). A family of related methods are evaluated in a task that requires subjects to search for small targets in a scene. The results show that scaling the velocity control by the near point in the scene and by the average point in the scene are equally effective.
Deriving Global Convection Maps From SuperDARN Measurements

A new statistical modeling technique for determining the global ionospheric convection is described. The principal component regression (PCR)‐based technique is based on Super Dual Auroral Radar Network (SuperDARN) observations and is an advanced version of the PCR technique that Waters et al. ( , https//:doi.org.10.1002/2015JA021596) used for the SuperMAG data. While SuperMAG ground magnetic field perturbations are vector measurements, SuperDARN provides line‐of‐sight measurements of the ionospheric convection flow. Each line‐of‐sight flow has a known azimuth (or direction), which must be converted into the actual vector flow. However, the component perpendicular to the azimuth direction is unknown. Our method uses historical data from the SuperDARN database and PCR to determine a fill‐in model convection distribution for any given universal time. The fill‐in data process is driven by a list of state descriptors (magnetic indices and the solar zenith angle). The final solution is then derived from a spherical cap harmonic fit to the SuperDARN measurements and the fill‐in model. When compared with the standard SuperDARN fill‐in model, we find that our fill‐in model provides improved solutions, and the final solutions are in better agreement with the SuperDARN measurements. Our solutions are far less dynamic than the standard SuperDARN solutions, which we interpret as being due to a lack of magnetosphere‐ionosphere inertia and communication delays in the standard SuperDARN technique while it is inherently included in our approach. Rather, we argue that the magnetosphere‐ionosphere system has inertia that prevents the global convection from changing abruptly in response to an interplanetary magnetic field change.
Muscle Dysfunction in COPD Metabolic derangements in COPD muscle dysfunction

Luis Puente-Maestu, Alberto Lázaro, and Blanca Humanes Servicio de Neumología, Hospital General Gregorio Marañón, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; and Laboratorio de Nefrología Experimental, Hospital General Gregorio Marañón, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain