Miracle-dz/UniFAR-FTUs huggingface dataset:
Localized muscle fatigue decreases the acuity of the movement sense in the human shoulder.

PURPOSE The purpose of this study was to investigate alterations in the movement sense acuity during localized muscle fatigue in the human dominant shoulder. METHODS Fourteen healthy volunteers (8 males and 6 females) with a mean age 23 +/- 2 yr participated in the study. The subjects' ability to discriminate movement velocity relative to a reference velocity imposed over the dominant shoulder was tested following two experimental conditions: 1) Light exercise (LE), repetitive isokinetic horizontal flexion/extensions at the shoulder, ranging from 85 degrees to 20 degrees relative to the frontal plane, at 10% of maximal voluntary contraction (MVC) and 2) Hard exercise (HE), same movements as in LE, but performing MVC to fatigue. RESULTS The results showed that subjects had a lower probability of distinguishing between different movement velocities following HE as compared with those during the LE condition (P < 0.001). When genders were compared, female subjects had a lower probability of distinguishing correctly than male subjects (P < 0.001). CONCLUSIONS The acuity of the movement sense in the dominant shoulder is reduced in the presence of shoulder muscle fatigue. The possible influence of muscle fatigue via peripheral muscle receptors on movement sense is discussed.
Pain Management in Ambulatory Surgery—A Review

Day surgery, coming to and leaving the hospital on the same day as surgery as well as ambulatory surgery, leaving hospital within twenty-three hours is increasingly being adopted. There are several potential benefits associated with the avoidance of in-hospital care. Early discharge demands a rapid recovery and low incidence and intensity of surgery and anaesthesia related side-effects; such as pain, nausea and fatigue. Patients must be fit enough and symptom intensity so low that self-care is feasible in order to secure quality of care. Preventive multi-modal analgesia has become the gold standard. Administering paracetamol, NSIADs prior to start of surgery and decreasing the noxious influx by the use of local anaesthetics by peripheral block or infiltration in surgical field prior to incision and at wound closure in combination with intra-operative fast acting opioid analgesics, e.g., remifentanil, have become standard of care. Single preoperative 0.1 mg/kg dose dexamethasone has a combined action, anti-emetic and provides enhanced analgesia. Additional α-2-agonists and/or gabapentin or pregabalin may be used in addition to facilitate the pain management if patients are at risk for more pronounced pain. Paracetamol, NSAIDs and rescue oral opioid is the basic concept for self-care during the first 3–5 days after common day/ambulatory surgical procedures.
Vigilance for pain-related faces in a primary task paradigm: an ERP study

Background Pain-related stimuli are supposed to be automatically prioritized over other stimuli. This prioritization has often been tested using primary task paradigms in which pain information is irrelevant for completing the explicitly posed task. Task-irrelevant stimuli are only processed if they are very salient, and pain-related stimuli are assumed to be salient enough. Objective We wanted to further investigate this assumption by assessing event-related brain potentials (ERPs) – a very sensitive method for studying attention and reaction times in response to pictures of people in pain and other emotional faces – using a primary task paradigm. In addition, we assumed that individuals describing themselves as vigilant to pain are especially responsive to pain cues. Methods One hundred pain-free subjects were tested in a primary task paradigm using pictures of facial expressions of pain, anger, happiness, and neutral mood. ERPs were assessed at midline electrodes. Vigilance to pain was assessed by the pain vigilance and awareness questionnaire. Results In contrast to previous studies (which have used pain words), effects of facial expressions of pain and other emotions on the ERPs and reaction times were surprisingly weak throughout and did not give evidence for a distinct processing of pain-related stimuli. However, hypervigilant subjects appeared to be strongly and cognitively absorbed by all emotional stimuli. Conclusion Accordingly, it appears that pain-related stimuli are not always of outstanding salience, but that certain characteristics (eg, type of material, emotional richness) have to be present, for pain-related stimuli to be prioritized over stimuli of other emotional content. Hypervigilance to pain may generally predispose individuals to process emotional stimuli in greater depth.
Efficacy of oral ciprofloxacin vs. clarithromycin for treatment of acute bacterial exacerbations of chronic bronchitis. The Bronchitis Study Group.

In this prospective, multicenter, double-blind study, the efficacy of ciprofloxacin was compared with that of clarithromycin as therapy for patients with acute bacterial exacerbations of chronic bronchitis (ABECB) from whom a pretherapy pathogen was isolated; the efficacy was measured by the infection-free interval. Clinical and microbiological responses at the end of therapy were secondary efficacy variables. Patients randomly received either ciprofloxacin or clarithromycin (500 mg twice a day for 14 days). Three hundred seventy-six patients with acute exacerbations of chronic bronchitis were enrolled in the study of whom 234 had an ABECB. Clinical resolution was observed in 90% (89 of 99) of ciprofloxacin recipients and 82% (75 of 91) of clarithromycin recipients for whom efficacy could be evaluated. The median infection-free interval was 142 days for ciprofloxacin recipients and 51 days for clarithromycin recipients (P = .15). Bacteriologic eradication rates were 91% (86 of 95) for ciprofloxacin recipients and 77% (67 of 87) for clarithromycin recipients (P = .01). In summary, compared with clarithromycin, treatment of ABECB with ciprofloxacin was associated with a trend toward a longer infection-free interval and a statistically significantly higher bacteriologic eradication rate.
Healthcare Utilization, Legal Incidents, and Victimization Following Traumatic Brain Injury in Homeless and Vulnerably Housed Individuals: A Prospective Cohort Study

Objective:To characterize the associations between a history of traumatic brain injury (TBI) and subsequent healthcare utilization, legal involvement, and victimization. Setting:Three major Canadian cities. Participants:A total of 1181 homeless and vulnerably housed adults who were single and 18 years or older. Data for 968 participants (82%) were available at 1-year follow-up. Design:Prospective cohort study. Data were collected using structured, in-person interviews at baseline in 2009 and approximately 1 year after baseline. Main Measures:Self-reported TBI, 12-item Short Form Health Survey, healthcare, and criminal justice use questionnaires. Results:The lifetime prevalence of TBI was 61%. A history of TBI was independently associated with emergency department (ED) use [adjusted odds ratio (AOR) = 1.5, 95% confidence interval (CI): 1.11–1.96], being arrested or incarcerated (AOR = 1.79, 95% CI: 1.3–2.48) and being a victim of physical assault (AOR = 2.81, 95% CI: 1.96–4.03) during the 1-year follow-up period. Conclusions:Homeless and vulnerably housed individuals with a lifetime history of TBI are more likely to be ED users, arrested or incarcerated, and victims of physical assault over a 1-year follow-up period even after adjustment for health status and other confounders. These findings have public health and criminal justice implications and highlight the need for effective screening, treatment, and rehabilitation for TBI in this population.
The stress-driven migration of point defects to a slowly moving crack

The migration kinetics of point defects near a slowly moving brittle crack are studied under the condition of pure drift. In the pure-drift approximation it is assumed that the point-defect flow in the vicinity of a crack tip is dominated by the elastic interaction between the stress field of the crack and a point defect and that concentration gradient effects can be neglected. While such a pure-drift approach has been shown to be useful to calculate the short-time diffusion kinetics of impurity-induced subcritical crack growth, previous applications are based on the drift solutions for a stationary crack. In the present paper, the first-order drift diffusion equation for a slowly moving crack at uniform velocity is solved. This yields the flow lines of the point defects and the impurity segregation rate directly in terms of the crack growth rate. The flow line patterns reveal important insights with respect to the point-defect migration kinetics near a steadily advancing crack. Although the calculation i.
Deep Recurrent Generative Decoder for Abstractive Text Summarization

We propose a new framework for abstractive text summarization based on a sequence-to-sequence oriented encoder-decoder model equipped with a deep recurrent generative decoder (DRGN). Latent structure information implied in the target summaries is learned based on a recurrent latent random model for improving the summarization quality. Neural variational inference is employed to address the intractable posterior inference for the recurrent latent variables. Abstractive summaries are generated based on both the generative latent variables and the discriminative deterministic states. Extensive experiments on some benchmark datasets in different languages show that DRGN achieves improvements over the state-of-the-art methods.
Measuring the rate of progression and estimating the preclinical period of Parkinson’s disease with [18F]dopa PET

OBJECTIVES To measure the rate of progression in striatal [18F]dopa metabolism in a large group (n=32) of patients with Parkinson’s disease, to estimate the average duration of preclinical period, and to examine the influence of the PET method on the assessment of rate of progression and preclinical period. METHODS Thirty two patients with Parkinson’s disease (mean age 58 (SD 13) years, mean duration 39 (SD 33) months) were assessed with [18F]dopa PET and UPDRS scoring on two occasions a mean of 18 (SD 6) months apart. PET data were sampled with separate caudate and putamen and total striatal regions of interest, and both graphical (Ki) and ratio methods of analysis. RESULTS The mean annual rate of deterioration in [18F]dopa uptake varied according to structure and method of analysis, with putamen Ki showing the most rapid mean rate of progression (4.7% of normal mean per year). The group showed a significant deterioration (p<0.0004, paired two tailed ttest) in UPDRS and in the putamen (p=0.008) and total striatal (p=0.012) [18F]dopa uptake measured using a graphical analysis, but no significant change in caudate or putamen uptake measured by a ratio approach. A study of sensitivity confirmed that putamen Ki was the most sensitive measure of disease progression, caudate ratio the least. Symptom onset in Parkinson’s disease was estimated at a mean putamen [18F]dopa uptake (Ki) of 75% of normal and a mean caudate [18F]dopa uptake (Ki) of 91% of normal. CONCLUSIONS Estimation of mean rate of progression varies according to the sensitivity of a functional imaging method to clinical severity. Sensitivity and reproducibility of method must be considered when designing studies of disease progression and neuroprotection. The mean preclinical period in Parkinson’s disease is unlikely to be longer than seven years.
Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

Previous studies demonstrated that the cysteine-rich amino-terminal domain of Raf-1 kinase interacts selectively with phosphatidylserine (Ghosh, S., Xie, W. Q., Quest, A. F. G., Mabrouk, G. M., Strum, J. C., and Bell, R. M.(1994) J. Biol. Chem. 269, 10000-10007). Further analysis showed that full-length Raf-1 bound to both phosphatidylserine and phosphatidic acid (PA). Specifically, a carboxyl-terminal domain of Raf-1 kinase (RafC; residues 295-648 of human Raf-1) interacted strongly with phosphatidic acid. The binding of RafC to PA displayed positive cooperativity with Hill numbers between 3.3 and 6.2; the apparent K ranged from 4.9 ± 0.6 to 7.8 ± 0.9 mol % PA. The interaction of RafC with PA displayed a pH dependence distinct from the interaction between the cysteine-rich domain of Raf-1 and PA. Also, the RafC-PA interaction was unaffected at high ionic strength. Of all the lipids tested, only PA and cardiolipin exhibited high affinity binding; other acidic lipids were either ineffective or weakly effective. By deletion mutagenesis, the PA binding site within RafC was narrowed down to a 35-amino acid segment between residues 389 and 423. RafC did not bind phosphatidyl alcohols; also, inhibition of PA formation in Madin-Darby canine kidney cells by treatment with 1% ethanol significantly reduced the translocation of Raf-1 from the cytosol to the membrane following stimulation with 12-O-tetradecanoylphorbol-13-acetate. These results suggest a potential role of the lipid second messenger, PA, in the regulation of translocation and subsequent activation of Raf-1 in vivo.
Involvement of endogenous antioxidant systems in the protective activity of pituitary adenylate cyclase‐activating polypeptide against hydrogen peroxide‐induced oxidative damages in cultured rat astrocytes

Astroglial cells possess an array of cellular defense mechanisms, including superoxide dismutase (SOD) and catalase antioxidant enzymes, to prevent damages caused by oxidative stress. Nevertheless, astroglial cell viability and functionality can be affected by significant oxidative stress. We have previously shown that pituitary adenylate cyclase‐activating polypeptide (PACAP) is a potent glioprotective agent that prevents hydrogen peroxide (H2O2)‐induced apoptosis in cultured astrocytes. The purpose of this study was to investigate the potential protective effect of PACAP against oxidative‐generated alteration of astrocytic antioxidant systems. Incubation of cells with subnanomolar concentrations of PACAP inhibited H2O2‐evoked reactive oxygen species accumulation, mitochondrial respiratory burst, and caspase‐3 mRNA level increase. PACAP also stimulated SOD and catalase activities in a concentration‐dependent manner, and counteracted the inhibitory effect of H2O2 on the activity of these two antioxidant enzymes. The protective action of PACAP against H2O2‐evoked inhibition of antioxidant systems in astrocytes was protein kinase A, PKC, and MAP‐kinase dependent. In the presence of H2O2, the SOD blocker NaCN and the catalase inhibitor 3‐aminotriazole, both suppressed the protective effects of PACAP on SOD and catalase activities, mitochondrial function, and cell survival. Taken together, these results indicate that the anti‐apoptotic effect of PACAP on astroglial cells can account for the activation of endogenous antioxidant enzymes and reduction in respiration rate, thus preserving mitochondrial integrity and preventing caspase‐3 expression provoked by oxidative stress. Considering its powerful anti‐apoptotic and anti‐oxidative properties, the PACAPergic signaling system should thus be considered for the development of new therapeutical approaches to cure various pathologies involving oxidative neurodegeneration.
The relevance of theobromine for the beneficial effects of cocoa consumption

Cocoa consumption began in America and in the mid sixteenth Century it quickly spread to Europe. Beyond being considered a pleasant habit due to its rich sweet lingering taste, chocolate was considered a good nutrient and even a medicine. Traditionally, health benefits of cocoa have been related with the high content of antioxidants of Theobroma cocoa beans. However, the direct psychoactive effect due to methylxanthines in cocoa is notable. Theobromine and caffeine, in the proportions found in cocoa, are responsible for the liking of the food/beverage. These compounds influence in a positive way our moods and our state of alertness. Theobromine, which is found in higher amounts than caffeine, seems to be behind several effects attributed to cocoa intake. The main mechanisms of action are inhibition of phosphodiesterases and blockade of adenosine receptors. Further mechanisms are being explored to better understand the health benefits associated to theobromine consumption. Unlike what happens in other mammals -pets- included, theobromine is safe for humans and has fewer unwanted effects than caffeine. Therefore, theobromine deserves attention as one of the most attractive molecules in cocoa.
Workflow mining: which processes can be rediscovered?

Contemporary workflow management systems are driven by explicit process models, i.e., a completely specified workflow design is required in order to enact a given workflow process. Creating a workflow design is a complicated time-consuming process and typically there are discrepancies between the actual workflow processes and the processes as perceived by the management. Therefore, we have developed techniques for {re)discovering workflow models. Starting point for such techniques are so-called "workflow logs" containing information about the workflow process as it is actually being executed. Unfortunately, it is not possible to {re)discover every workflow process. In this paper we explore the class of workflow processes which can be discovered. The theoretical results presented in this paper demonstrate that most practical workflow pro cesses fit into this class. The tool MiMo, also presented in this paper, supports the {re)discovery of these processes.
Detection of COPD in a high-risk population: should the diagnostic work-up include bronchodilator reversibility testing?

Background Underdiagnosis of chronic obstructive pulmonary disease (COPD) is widespread. Early detection of COPD may improve the outcome by timely smoking cessation, a change in lifestyle, and treatment with an inhaled bronchodilator (BD). The objective of this study was to evaluate the diagnostic role of BD reversibility testing in early COPD case finding. Methods General practitioners (n=241) consecutively recruited subjects aged ≥35 years with relevant exposure (history of smoking, and/or occupational exposure) and at least one respiratory symptom. Information on age, smoking status, body mass index, dyspnea score (Medical Research Council scale), and spirometry was obtained. Individuals with airway obstruction (forced expiratory volume in one second [FEV1]/forced vital capacity [FVC] <0.70) underwent a BD test with an inhaled β2 agonist, which was considered positive if ΔFEV1 was >0.20 L and >12%. Asthma and COPD were, respectively, defined as an FEV1 increase >0.50 L and a post-BD FEV1/FVC <0.70. Results In total, 4,049 subjects (51% male) were included (mean age 58 years, body mass index 27, 32 pack-years of smoking). A significant BD response was found in 143 (15%) of the 937 subjects (23%) with airway obstruction at screening spirometry. In 59% of these subjects, the post-BD FEV1/FVC remained <0.70. In 24% of the subjects with pre-BD airway obstruction, the post-BD FEV1/FVC ratio was within the reference range. In subjects with confirmed COPD, the mean increase in FEV1 following BD was 0.11 L±0.10 L. The subjects with COPD and a significant BD response were characterized by a higher prevalence of dyspnea (72% versus 57%, P=0.02) but less cough (55% versus 75%, P=0.001) when compared with COPD subjects without BD reversibility. Conclusion Administration of a BD in COPD case finding is important in order to determine the post-BD FEV1/FVC ratio. Exclusion of subjects with a significant BD response may result in underdiagnosis of COPD, and we question the need for the BD reversibility test in the diagnostic screening algorithm in early COPD case finding.
Methodology of the ZOC-BHVI High Myopia Cohort Study: The Onset and Progression of Myopic Pathologies and Associated Risk Factors in Highly Myopic Chinese

ABSTRACT Purpose: The increasing prevalence of high myopia and its associated pathologies has raised challenges to ophthalmic services. This project aims to explore the onset and progression of myopic pathologies in highly myopic eyes through a prospective research cohort established in South China. Methods: Patients with high myopia (sphere ≤ −6.00 D) visiting the optometric clinic of Zhongshan Ophthalmic Center (ZOC) were invited to participate in the baseline examinations and follow-up visit over a 10-year period. People having secondary myopia, history of any refractive surgery, significant ocular media opacity, or other severe health problems were excluded. The measurements included visual acuity, ocular biometry, visual function, cycloplegic refraction, fundus imaging, ocular shape by MRI, blood tests and questionnaires. Results: A total of 890 participants completed the baseline examinations, with a mean age at baseline of 22.7 ± 12.4 years. The mean spherical equivalent at baseline was 10.13 ± 3.65 D, and the mean axial length (AL) was 27.52 ± 1.63 mm. The older subjects tended to have more severe myopia and longer ALs. Conclusion: The study will provide new knowledge on the relationship between high myopia and pathological changes such as myopic macular degeneration and staphyloma.
Improved Bounds for the Crossing Numbers of Km, n and Kn

It has been long conjectured that the crossing number $\Cr(K_{m,n})$ of the complete bipartite graph $K_{m,n}$ equals the Zarankiewicz number $Z(m,n):= \floor{\frac{m-1}{2}} \floor{\frac{m}{2}} \floor{\frac{n-1}{2}} \floor{\frac{n}{2}}$. Another longstanding conjecture states that the crossing number $\Cr(K_n)$ of the complete graph $K_n$ equals $Z(n):=\frac{1}{4}\smallfloor{\frac{n}{2}} \smallfloor{\frac{n-1}{2}} \smallfloor{\frac{n-2}{2}}\smallfloor{\frac{n-3}{2}}$. In this paper we show the following improved bounds on the asymptotic ratios of these crossing numbers and their conjectured values: \begin{itemize} \item[(i)] for each fixed $m\ge 9$, $\lim_{n\to\infty} \Cr(K_{m,n})/Z(m,n) \ge 0.83m/(m-1)$; \item[(ii)] $\lim_{n\to\infty} \Cr(K_{n,n})/Z(n,n) \ge 0.83$; and \item[(iii)] $\lim_{n\to\infty} \Cr(K_{n})/Z(n) \ge 0.83$. \end{itemize} The previous best known lower bounds were $0.8m/(m-1), 0.8$, and $0.8$, respectively. These improved bounds are obtained as a consequence of the new bound $\Cr(\ksn) \ge 2.1796n^2 - 4.5n$. To obtain this improved lower bound for $\Cr(\ksn)$, we use some elementary topological facts on drawings of $K_{2,7}$ to set up a quadratic program on $6! $ variables whose minimum $p$ satisfies $\Cr(\ksn) \ge (p/2)n^2 - 4.5n$, and then use state-of-the-art quadratic optimization techniques combined with a bit of invariant theory of permutation groups to show that $p \ge 4.3593$.
Summarizing Scientific Texts: Experiments with Extractive Summarizers

In this paper we present experiments on scientific text summarization. From a complete text, we produce a shorter version containing all the main parts of the research. Having in mind the sophisticated structure of such texts, we show that good results can be achieved using simple extractive summarizers with some obvious improvements that consider the specificity of the text genre. Specifically, we enhance the summarization process with the ability to detect and appropriately treat the text structure.