Miracle-dz/UniFAR-FTUs huggingface dataset:
Fuzzy ART and Fuzzy ARTMAP with adaptively weighted distances

In this paper, we introduce a modification of the Fuzzy ARTMAP (FAM) neural network, namely, the Fuzzy ARTMAP with adaptively weighted distances (FAMawd) neural network. In FAMawd we substitute the regular L1-norm with a weighted L1-norm to measure the distances between categories and input patterns. The distance-related weights are a function of a category's shape and allow for bias in the direction of a category's expansion during learning. Moreover, the modification to the distance measurement is proposed in order to study the capability of FAMawd in achieving more compact knowledge representation than FAM, while simultaneously maintaining good classification performance. For a special parameter setting FAMawd simplifies to the original FAM, thus, making FAMawd a generalization of the FAM architecture. We also present an experimental comparison between FAMawd and FAM on two benchmark classification problems in terms of generalization performance and utilization of categories. Our obtained results illustrate FAMawd's potential to exhibit low memory utilization, while maintaining classification performance comparable to FAM.
The Development of the Youth Empowerment Scale

This study developed and validated the Youth Empowerment Scale (YES) for young people with psychosis. This PhD thesis consisted of four phases. Phase 1 conceptualised empowerment from the perspective of young people with psychosis. Phase 1 qualitative findings informed the development of the measurement of empowerment; the Youth empowerment Scale (YES). Phase 2 developed and validated the YES in a non-clinical population. Phase 3 explored the relationship between psychological processes (self-efficacy, control, coping, thinking style, and social support), empowerment, mental health wellbeing and recovery. The YES was then validated again in phase 4 on a clinical population, young people within Child and Adolescents Mental Health Services (CAMHS). This study confirmed that the YES is a valid and reliable measure of empowerment which can be used in future work identifying and supporting empowerment for young people with psychosis.
Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism.

The Class I and III polyhydroxybutyrate (PHB) synthases from Ralstonia eutropha and Chromatium vinosum, respectively, catalyze the polymerization of beta-hydroxybutyryl-coenzyme A (HBCoA) to generate PHB. These synthases have different molecular weights, subunit composition, and kinetic properties. Recent studies with the C. vinosum synthase suggested that it is structurally homologous to bacterial lipases and allowed identification of active site residues important for catalysis [Jia, Y. , Kappock, T. J., Frick, T. , Sinskey, A. J., and Stubbe, J. (2000) Biochemistry 39, 3927-3936]. Sequence alignments between the Class I and III synthases revealed similar residues in the R. eutropha synthase. Site-directed mutants of these residues were prepared and examined using HBCoA and a terminally saturated trimer of HBCoA (sT-CoA) as probes. These studies reveal that the R. eutropha synthase possesses an essential catalytic dyad (C319-H508) in which the C319 is involved in covalent catalysis. A conserved Asp, D480, was shown not to be required for acylation of C319 by sT-CoA and is proposed to function as a general base catalyst to activate the hydroxyl of HBCoA for ester formation. Studies of the [(3)H]sT-CoA with wild-type and mutant synthases reveal that 0.5 equiv of radiolabel is covalently bound per monomer of synthase, suggesting that a dimeric form of the enzyme is involved in elongation. These studies, in conjunction with search algorithms for secondary structure, suggest that the Class I and III synthases are mechanistically similar and structurally homologous, despite their physical and kinetic differences.
Noticing and Helping Neglected Children: Messages from Action on Neglect

This paper sets out the messages from Action on Neglect, an Economic and SocialResearch Council Follow on Fund-sponsored project which ran from April 2011 to theend of March 2012 in England. Undertaken by a small team of researchers andpractitioners from the universities of Stirling and Dundee and the national charity Actionfor Children, it was a follow-up to a literature review produced as part of theSafeguarding Children Across Services Research Initiative.The project team met with multidisciplinary groups of practitioners and managersfromall keyprofessionsworking with childreninthreeareasofEngland onfour occasions.The messages from the study were used to consider the extent to which current practiceequateswith evidence from the research. Through a process of co-production, the projectexplored the ways in which neglected children are currently helped and considered whatcould be done to improve recognition and early response.The ﬁnalproductwasapack –ActiononNeglect –thatoutlinesaseriesofdetailedworkedexamples setting out improved pathways to help for neglected children and their families.Copyright © 2014 John Wiley & Sons, Ltd.K
İŞ TATMİNİ VE ÖRGÜTSEL BAĞLILIĞIN İNCELENMESİNE YÖNELİK BİR ARAŞTIRMA

Bu calismanin amaci, Pamukkale Universitesinde calisan akademisyenlerin is tatmini/tatminsizligi ve orgutsel baglilik faktorlerinin goreceli onem derecelerini belirlemektir. Bu amacla, is tatmini duzeyi, Minnesota Is Tatmini Olcegine dayali olarak 17 soru ile olculmeye calisilmistir.Orgutsel baglilik ise Cook ve Wall’in orgutsel baglilik Olcegine gore gorer hazirlanmis 10 soruyla degerlendirilmistir. Amprik analizlere dayali arastirma sonuclari is tatminini etkileyen faktorlerle, akademisyenlerin is tatmini uzerinde etkili oldugunu dusundugu faktorler arasinda onemli farkliliklar oldugunu gostermektedir. Orgutsel baglilik acisindan ise, sadakat ve is istekliligine gore ozellikle kimlik birligini olcen sorulara daha dusuk degerler verildigi dikkat cekmektedir.
Molecular mechanisms in lymphangiogenesis: model systems and implications in human disease

The basic science and development of therapies targeting the blood vascular system has enjoyed much focus due to the knowledge of the molecular mechanisms behind its development and roles in disease. However, the closely associated lymphatic system, while also being responsible for a number of serious and debilitating diseases, has not garnered as much attention due to the lack of specific molecular markers, thereby limiting this field to no more than descriptive analysis. Within the past decade, great strides have been taken to identify a number of molecular signatures unique to the lymphatic system. To this end, the timeline for lymphatic development has now been redefined at the molecular level, and diseases associated with lymphatics now have a molecular basis. With this knowledge, the current modes of treatment for disease such as lymphedema, lymphangiomas, and metastatic progression can now be augmented with potential molecular therapies that have currently been tested in a number of animal models. Much like the therapeutics that have been associated with vasculogenesis and angiogenesis, manipulation of the molecular pathways that define lymphatic development may lead to better clinical outcomes associated with developmental defects and disease.
Auraptene from Ferula szowitsiana protects human peripheral lymphocytes against oxidative stress

The antigenotoxicity effects of auraptene on DNA damage in human peripheral lymphocytes were studied using alkaline single cell gel electrophoresis. Auraptene at concentrations of 5, 10, 25, 50, 100, 200 and 400 µM was tested under simultaneous treatment with 25 µM H2O2. The data are expressed as % tail DNA and compared with ascorbic acid at concentrations of 25, 50, 100, 200 and 400 µM. Auraptene significantly reduced the genotoxicity of H2O2 at concentrations higher than 25 µM (p < 0.001). Interestingly, the antigenotoxicity activity of auraptene was higher than ascorbic acid (p < 0.01), however, at some concentrations (25, 50 and 200 µM) there was no significant difference between auraptene and ascorbic acid (p > 0.05). It seems that the significant antigenotoxicity effects of auraptene may be due to the prenyl moiety and also the suppression of superoxide anion (O2−) generation. This study suggests that the antigenotoxic property of auraptene is of great pharmacological importance and might be beneficial for cancer prevention. Copyright © 2009 John Wiley & Sons, Ltd.
Type 1 Diabetic Children and Siblings Share a Decrease in Dendritic Cell and Monocyte Numbers but are Differentiated by Expansion of CD4 + T Cells Expressing IL-17

Type 1 diabetes (T1D) is an autoimmune disease characterised by multiple defects of immune cells which allow the expansion of pathogenic β cell-specific T effector cells and subsequent T1D development. We performed immunomonitoring assays on blood immune cells in T1D children, their siblings and controls with the supposition that the results would elucidate the sequence of abnormalities in peripheral immune cells leading to the progression of autoimmunity from non-diabetic siblings to diabetic children. We assessed myeloid dendritic cell (MDC), plasmacytoid (P)DC, monocyte, CD4+T and CD8+T cell compartments, and cytokine expression in CD4+T cells and CD8+T cells, by polychromatic flow cytometry in erythrocyte-lysed fresh blood. The numbers of CD16+MDC, PDC and CD16+ monocytes were similarly decreased in diabetic children and their siblings. Whereas the numbers of CD16-CD141-MDC, CD16-CD141+MDC, CD16- monocytes, T naive (CD45RO-CD62L+), T central memory (CD45RO+CD62L+), T effector memory (CD45RO+CD62L-), T terminally-differentiated effector (CD45ROCD62L-) and T regulatory cells (CD4+CD25+127lo/- or CD4+Foxp3+ cells) were not affected in diabetic children or their siblings. Furthermore, analysis of cytokine expression in CD4+T cells and CD8+T cell revealed an increased proportion of CD4+T cells expressing IL-17, differentiating diabetic children from their non-diabetic siblings. Our data suggest that diabetic children and their siblings suffer a considerable reduction of blood immune cells involving CD16+MDC, PDC and CD16+ monocytes that may result from shared genetic or environmental factors. However, this reduction of blood immune cells requires combination with the proinflammatory cytokine IL-17 to allow disease expression in diabetic children.
A Randomized, Double-blinded Trial of a “Rule of Threes” Algorithm versus Continuous Infusion of Oxytocin during Elective Cesarean Delivery

Background:The administration of uterotonic agents during cesarean delivery is highly variable. The authors hypothesized a “rule of threes” algorithm, featuring oxytocin 3 IU, timed uterine tone evaluations, and a systematic approach to alternative uterotonic agents, would reduce the oxytocin dose required to obtain adequate uterine tone. Methods:Sixty women undergoing elective cesarean delivery were randomized to receive a low-dose bolus or continuous infusion of oxytocin. To blind participants, the rule group simultaneously received intravenous oxytocin (3 IU/3 ml) and a “wide-open” infusion of 0.9% normal saline (500 ml); the standard care group received intravenous 0.9% normal saline (3 ml) and a “wide-open” infusion of oxytocin (30 IU in 0.9% normal saline/500 ml). Uterine tone was assessed at 3, 6, 9, and 12 min, and if inadequate, additional uterotonic agents were administered. Uterine tone, total dose and timing of uterotonic agent use, maternal hemodynamics, side effects, and blood loss were recorded. Results:Adequate uterine tone was achieved with lower oxytocin doses in the rule versus standard care group (mean, 4.0 vs. 8.4 IU; point estimate of the difference, 4.4 ± 1.0 IU; 95% CI, 2.60 to 6.15; P < 0.0001). No additional oxytocin or alternative uterotonic agents were needed in either group after 6 min. No differences in the uterine tone, maternal hemodynamics, side effects, or blood loss were observed. Conclusion:A “rule of threes” algorithm using oxytocin 3 IU results in lower oxytocin doses when compared with continuous-infusion oxytocin in women undergoing elective cesarean delivery.
TeV with the CMS experiment

A measurement of the J/ψ and ψ(2S) production cross sections in pp collisions at √ s = 7 TeV with the CMS experiment at the LHC is presented. The data sample corresponds to an integrated luminosity of 37 pb −1. Using a fit to the invariant mass and decay length distributions, production cross sections have been measured separately for prompt and non-prompt charmonium states, as a function of the meson transverse momentum in several rapidity ranges.
Memory: Organization and locus of change

The chapters represent state-of-the-art work on neuroplasticity at all levels: behavioral, neural, and molecular. They describe recent work on memory ranging from cellular morphological studies in invertebrates to research on the human brain made possible by new advances in neuroimaging technology. The book begins with an introductory chapter that considers the psychology of memory at the global, structural level. The remainder of the volume is divided into three related parts. The first focuses on recent approaches, which are based in part on new technology, that aim to measure and describe activity in relatively large populations of neurons. The second focuses on memory at the level of brain systems. One major theme to emerge from work at this level is that memory is composed of multiple, separable components that can be identified with specific anatomical structures and connections. The third part of the book focuses on molecular and cellular studies that show how individual neurons and their synapses behave in a history-dependent manner. This research concerns both brief changes in synaptic plasticity as well as more lasting changes in connectivity, which depend on altered gene expression and morphological growth and change. Altogether, the chapters provide a rich summary of the breadth and excitement of contemporary research on the biology of memory.
Increased propensity for apnea in response to acute elevations in left atrial pressure during sleep in the dog.

Periodic breathing is commonly observed in chronic heart failure (CHF) when pulmonary capillary wedge pressure is abnormally high and there is usually concomitant tachypneic hyperventilation. We hypothesized that acute pulmonary hypertension at pressures encountered in CHF and involving all of the lungs and pulmonary vessels would predispose to apnea/unstable breathing during sleep. We tested this in a chronically instrumented, unanesthetized dog model during non-rapid eye movement (NREM) sleep. Pulmonary hypertension was created by partial occlusion of the left atrium by means of an implanted balloon catheter in the atrial lumen. Raising mean left atrial pressure by 5.7 +/- 1.1 Torr resulted immediately in tachypneic hyperventilation [breathing frequency increased significantly from 13.8 to 19.9 breaths/min; end-tidal P(CO2) (P(ET(CO2))) fell significantly from 38.5 to 35.9 Torr]. This tachypneic hyperventilation was present during wakefulness, NREM sleep, and rapid eye movement sleep. In NREM sleep, this increase in left atrial pressure increased the gain of the ventilatory response to CO2 below eupnea (1.3 to 2.2 l.min(-1). Torr(-1)) and thereby narrowed the CO2 reserve [P(ET(CO2)) (apneic threshold) - P(ET(CO2)) (eupnea)], despite the decreased plant gain resulting from the hyperventilation. We conclude that acute pulmonary hypertension during sleep results in a narrowed CO2 reserve and thus predisposes toward apnea/unstable breathing and may, therefore, contribute to the breathing instability observed in CHF.
Sequential Total Variation Denoising for the Extraction of Fetal ECG from Single-Channel Maternal Abdominal ECG

Fetal heart rate (FHR) is an important determinant of fetal health. Cardiotocography (CTG) is widely used for measuring the FHR in the clinical field. However, fetal movement and blood flow through the maternal blood vessels can critically influence Doppler ultrasound signals. Moreover, CTG is not suitable for long-term monitoring. Therefore, researchers have been developing algorithms to estimate the FHR using electrocardiograms (ECGs) from the abdomen of pregnant women. However, separating the weak fetal ECG signal from the abdominal ECG signal is a challenging problem. In this paper, we propose a method for estimating the FHR using sequential total variation denoising and compare its performance with that of other single-channel fetal ECG extraction methods via simulation using the Fetal ECG Synthetic Database (FECGSYNDB). Moreover, we used real data from PhysioNet fetal ECG databases for the evaluation of the algorithm performance. The R-peak detection rate is calculated to evaluate the performance of our algorithm. Our approach could not only separate the fetal ECG signals from the abdominal ECG signals but also accurately estimate the FHR.
Cytotype distribution at a diploid-hexaploid contact zone in Aster amellus (Asteraceae).

BACKGROUND AND AIMS The present study aims to assess the diversity and distribution of cytotypes of Aster amellus in central and eastern Europe, contributing with data to improve understanding of the evolutionary dynamics of the contact zone between diploids and hexaploids of this polyploid complex. METHODS Large-scale cytotype screening of 4720 individuals collected in 229 populations was performed using 4',6-diamidino-2-phenylindole (DAPI) flow cytometry. Fine-scale cytotype screening was performed in the mixed-ploidy population. Reproductive variables, such as number of florets per flower head, seed set and seedling emergence, as well as ploidy level of seeds and seedlings were recorded in this population. KEY RESULTS The diploid-hexaploid contact zone is large and complex, reaching the Czech Republic in the west, Austria in the south, Poland in the north-east and Romania in the extreme east of the surveyed areas. Most populations presented only one cytotype, either diploid or hexaploid. In several areas of the contact zone both cytotypes were found to grow in parapatry. One mixed-ploidy population of diploids and hexaploids was detected for the first time, but no signs of hybridization were detected. In this population, diploids had a significantly lower reproductive success, and significantly higher production of intercytotype offspring, being in reproductive disadvantage in comparison with hexaploids. CONCLUSIONS The contact zone of diploid and hexaploid A. amellus in central and eastern Europe seems to be highly dynamic and diffuse, with both primary and secondary contacts being possible. The obtained results suggest the origin of hexaploids through diploids, overall supporting previous hypotheses that this species is autopolyploid. Data from the only mixed-ploidy population detected so far suggest that the minority cytotype exclusion is an important evolutionary mechanisms driving the prevalence of single-cytotype populations, and thus contributing to the current distributional patterns of the cytotypes of A. amellus.
High-Resolution Regional Phase Attenuation Models of the Iranian Plateau and Surrounding Regions

Abstract : The objective of this project is to construct regional wave (Pg, Sn, and Lg) attenuation models for the crust and upper mantle throughout the Iranian plateau and surrounding regions. This research should increase ray path coverage of critical areas and help to create robust regional phase amplitude and attenuation models. We have combined our Iranian data set with our existing Middle Eastern Lg waveform database. These two data sets, combined, give us reasonably good coverage of the northern Middle East. We have created a catalog of seismic events in and around Iran with reliable source spectra as well as tested regional phase attenuation maps for the Zagros and Iranian plateau. We have developed an Sn attenuation model using two station measurements of Q for regional phase Sn (0.1 to 0.5 Hz) and for high frequency Sn (0.5 to 2 Hz). We have also processed Pg waveforms in order to obtain robust estimates of Qp in the crust within the Iranian plateau. For most of the phases we see moderately high attenuation within the plateau and less attenuation along the Zagros mountains. This project is the first to use two station and reverse two station methods to measure attenuation of phases such as Pg and Sn.
Maximal Independent Sets in Heterogeneous Wireless Ad Hoc Networks

In ad hoc wireless networks, a Connected Dominating Set (CDS) has been extensively used as a Virtual Backbone (VB) for routing. The majority of approximation algorithms for constructing a small CDS in wireless ad hoc networks follow a general two-phased approach. The first phase is to construct a Dominating Set (DS) and the second phase is to connect the nodes in it. Generally, in the first phase, a Maximum Independent Set (MIS) is used as the DS. The relation between the size of a Maximum Independent Set and a Minimum Connected Dominating Set (MCDS) plays the key role in the performance analyses of these two-phased algorithms. In homogeneous wireless ad hoc networks modeled as Unit Disk Graphs (UDG) and Unit Ball Graphs (UBG), the relation between them has been well studied. However, in heterogeneous wireless networks which generally modeled as Disk Graphs with Bidirectional links (DGB) and Ball Graphs with Bidirectional links (BGB), upper bounds for the size of MISs have seldom been studied. In this paper, we give tighter upper bounds for the size of MISs in heterogeneous wireless ad hoc networks. When the maximum and minimum transmission range are relatively close, our result is much better. In DGB, when the transmission range ratio is (1,1.152], (1.152,1.307], (1.307,1.407], (1.407,1.462], (1.462,1.515], (1.515,1.618], (1.618,1.932], we prove that the size of any Maximal Independent Set (MIS) is upper bounded by 6opt + 1, 7opt + 1, 8opt + 1, 9opt + 1, 10opt + 1, 11opt + 1, 16.7778opt + 1.2222, where opt denotes the size of an optimal solution of the CDS problem.
Interdisciplinary Training for Effective Implementation of Services in Response to a Social Policy Change

ABSTRACT This article describes an interdisciplinary (law and social work) training program for child welfare staff and attorneys that was implemented and tested in an extremely socially disadvantaged region in response to the legislative mandates of the Adoption and Safe Families Act of 1997. This project was undertaken by university-public agency collaboration and as such is part of a nation-wide trend to encourage partnerships that can enhance the delivery of quality services to children and families coming to the attention of the child welfare system. Coming at a time when the federal government is emphasizing the need for safety, permanency, and child well-being for children entering foster care, an interdisciplinary project that is effective in training staff to meet these objectives is timely.