Miracle-dz/UniFAR-FTUs huggingface dataset:
Contrast-Enhanced Ultrasound as a New Investigative Tool in Diagnostic Imaging of Muscle Injuries—A Pilot Study Evaluating Conventional Ultrasound, CEUS, and Findings in MRI

Objective: To emphasize the diagnostic value of contrast-enhanced ultrasound (CEUS) in the imaging of muscle injuries with different degrees of severity by comparing findings to established imaging modalities such as conventional ultrasound and magnetic resonance imaging (MRI). Design: Case series. Setting: Institutional study. Conventional ultrasound and CEUS were performed in the Department of Internal Medicine. Magnetic resonance imaging was carried out in the Department of Radiology within the Magnetom Avanto 1.5T and Magnetom Skyra fit 3T (Siemens Healthineers, Erlangen, Germany) and in the Institution of Imaging Diagnostics and Therapy (Magnetom Avanto 1.5T; Siemens, Erlangen, Germany). Patients: Fifteen patients who underwent an acute muscle injury were recruited. Main Outcome Measures: The appearance and detectable size of muscle injuries were compared between each imaging modality. The injuries were assessed by 3 independent observers and blinded between imaging modalities. Results: All 15 injuries were identified on MRI and CEUS, whereas 10 injuries showed abnormalities in conventional ultrasound. The determination and measurement revealed significant differences between conventional ultrasound and CEUS depending on injury severity. Contrast-enhanced ultrasound revealed an impairment of microcirculation in grade I lesions (corresponding to intramuscular edema observed in MRI), which was not detectable using conventional ultrasound. Conclusions: Our results indicate that performing CEUS seems to be a sensitive additional diagnostic modality in the early assessment of muscle injuries. Our results highlight the advantages of CEUS in the imaging of low-grade lesions when compared with conventional ultrasound, as this was the more accurate modality for identifying intramuscular edema.
Effect of clotrimazole on microsomal metabolism and pharmacokinetics of albendazole

Albendazole is a broad spectrum anthelmintic drug widely used in human and veterinary medicine. Intestinal and hepatic albendazole metabolism leads to albendazole sulfoxide (active metabolite) and albendazole sulfone (inactive metabolite) formation. Microsomal sulfonase activity can be abolished by in‐vitro interaction with clotrimazole and pharmacokinetic studies confirm this interaction. After albendazole incubation, albendazole sulfone formation was completely inhibited by 50 μm clotrimazole in intestinal incubations and a 50% inhibition was observed in hepatic incubations. The lower inhibition constant (Ki) value observed in the intestinal incubations (9.4 ± 1.0 μm) compared with the hepatic counterparts (23.3 ± 15.8 μm) pointed to a greater affinity of the enzymatic systems in the intestine. Regarding the formation of albendazole sulfoxide, an inhibition close to 50% was observed in liver and intestine at 10 μm clotrimazole. The pharmacokinetic parameters obtained following the oral co‐administration of albendazole sulfoxide and clotrimazole corroborated the in‐vitro inhibition of albendazole sulfone formation, since the ratio of the area under the plasma concentration‐time curves for the sulfoxide/sulfone (AUCABZSO/AUCABZSO2) was significantly higher (38.1%). In addition, the AUC and Cmax for albendazole sulfone were significantly lower. The effect of clotrimazole was also studied after prolonged treatment. Hepatic microsomal metabolism of albendazole was induced after 10 days of clotrimazole administration, with significant increases in formation of albendazole sulfoxide (40%) and sulfone (27%). These results offer further insight into the metabolism of benzimidazole drugs and highlight the difficulty involved in human therapy with these anthelmintics, since after prolonged treatment the drug interactions are affected differentially.
Racial/ethnic variation in asthma status and management practices among children in managed medicaid.

OBJECTIVE Racial/ethnic disparities in hospitalization rates among children with asthma have been documented but are not well-understood. Medicaid programs, which serve many minority children, have markedly increased their use of managed care in recent years. It is unknown whether racial/ethnic disparities in health care use or other processes of care exist in managed Medicaid populations. This study of Medicaid-insured children with asthma in 5 managed care organizations aimed to 1) compare parent-reported health status and asthma care processes among black, Latino, and white children and 2) test the hypothesis that racial/ethnic variations in processes of asthma care exist after adjusting for socioeconomic status and asthma status. METHODS This cross-sectional study collected data via telephone interviews with parents and computerized records for Medicaid-insured children with asthma in 5 managed care organizations in California, Washington, and Massachusetts. The American Academy of Pediatrics (AAP) Children's Health Survey for Asthma was used to measure parent-reported asthma status. We used multivariate models to evaluate associations between race/ethnicity and asthma status while controlling for other sociodemographic variables. We evaluated racial/ethnic variations in selected processes of asthma care while controlling for other demographic variables and asthma status. RESULTS The response rate was 63%. Of the 1658 children in the respondent group, 38% were black, 19% were Latino, and 31% were white. Black children had worse asthma status than white children on the basis of the AAP asthma physical and emotional health scores, symptom-days, and school days missed in the past 2 weeks. Latino children had equivalent AAP scores but missed more school days than white children. On the basis of the AAP asthma physical health score, the black-white disparity persisted after adjusting for other sociodemographic variables. After adjusting for sociodemographic variables and asthma status, black and Latino children were less likely to be using inhaled antiinflammatory medication than white children (relative risk for blacks: 0.69; relative risk for Latinos: 0.58). They were more likely to have home nebulizers. Other processes of asthma care, including ratings of providers and asthma care, use of written management plans, use of preventive visits and specialists, and having no pets or smokers at home, were equal or better for minority children compared with white children. CONCLUSIONS Black and Latino children had worse asthma status and less use of preventive asthma medications than white children within the same managed Medicaid populations. Most other processes of asthma care seemed to be equal or better for minorities in the populations that we studied. Increasing the use of preventive medications is a natural focus for reducing racial disparities in asthma.
Investment in Schooling and the Marriage Market

We present a model in which investment in schooling generates two kinds of returns: the labor-market return, resulting from higher wages, and a marriage-market return, defined as the impact of schooling on the marital surplus share one can extract. Men and women may have different incentives to invest in schooling because of different market wages or household roles. This asymmetry can yield a mixed equilibrium with some educated individuals marrying uneducated spouses. When the labor-market return to schooling rises, home production demands less time, and the traditional spousal labor division norms weaken, more women may invest in schooling than men. (JEL I21, J12, J24, J31)
Asp-286----Asn-286 in polyomavirus large T antigen relaxes the specificity of binding to the polyomavirus origin

We isolated revertants of a polyomavirus whose origin of DNA replication contains a point mutation in the palindrome to which large T antigen binds. Four independent second-site revertants contain an Asp-286----Asn-286 substitution in large T antigen. This mutant large T antigen activates replication of DNAs containing the mutant polyomavirus origin as well as replication of DNAs containing the wild-type origin; however, replication of DNAs with enhancer mutations is not activated by this large T antigen. The Asn-286 mutation occurs in a positively charge region of large T antigen near the location of several mutations which inactivate DNA replication. We suggest that this region of large T antigen is responsible for recognition of specific DNA sequences at the origin and that ionic forces are important for this interaction.
The impact of a career intervention programme on South African Grade 11 learners’ career decision-making self-efficacy

There have been increasing calls for career development interventions that take the local context into account while providing a firm theoretical basis to engage with the career processes and attributes of individuals coming from diverse backgrounds. The goal of this study was to determine the effect of a career intervention programme derived from Social Cognitive Career Theory on the career decision-making self-efficacy of Grade 11 learners at three schools with diverse socio-economic backgrounds in the Eastern Cape. Using a quasi-experimental design, measurements were taken at a pretest, post-test and a follow-up occasion 8 weeks after the completion of the programme in a sample of 222 learners using the Career Decision-Making Self-Efficacy Scale. The study demonstrated that the career decision-making self-efficacy of the intervention group improved significantly subsequent to the career intervention programme underscoring the value of the career intervention programme. Although the current study demonstrated a medium effect on the intervention group by the end of the intervention, the time period of the programme may not have been long enough to sustain the impact 8 weeks after the completion of the programme. This may suggest that a longer intervention period or intermittent reinforcement such as booster sessions may be needed to sustain the effect. The study confirms that a group-based career development programme, designed specifically for the South African context, can serve as an essential tool to help high school learners from different socio-economic backgrounds enhance their career maturity expressed in terms of their career decision-making self-efficacy.
INSTRUCTIONAL DESIGN AND ASSESSMENT An Interdisciplinary Online Course in Health Care Informatics

Objectives. To design an interdisciplinary course in health care informatics that enables students to: (1) understand how to incorporate technology into the provision of safe, effective and evidence-based health care; (2) make decisions about the value and ethical application of specific technologies; and (3) appreciate the perspectives and roles of patients and providers when using technology in care. Design. An online, interdisciplinary elective course using a distributive learning model was created. Standard courseware was used to manage teaching and to facilitate student/instructor interactions. Interactive, multimedia lectures were developed using Internet communication software. Assessment. Upon completion of the course, students demonstrated competency in identifying, analyzing, and applying informatics appropriately in diverse health settings. Conclusion. Online education using multimedia software technology is effective in teaching students about health informatics and providing an innovative opportunity for interdisciplinary learning. In light of the growing need for efficient health care informatics training, additional study of this methodology is warranted.
N‐terminome analysis of the human mitochondrial proteome

The high throughput characterization of protein N‐termini is becoming an emerging challenge in the proteomics and proteogenomics fields. The present study describes the free N‐terminome analysis of human mitochondria‐enriched samples using trimethoxyphenyl phosphonium (TMPP) labelling approaches. Owing to the extent of protein import and cleavage for mitochondrial proteins, determining the new N‐termini generated after translocation/processing events for mitochondrial proteins is crucial to understand the transformation of precursors to mature proteins. The doublet N‐terminal oriented proteomics (dN‐TOP) strategy based on a double light/heavy TMPP labelling has been optimized in order to improve and automate the workflow for efficient, fast and reliable high throughput N‐terminome analysis. A total of 2714 proteins were identified and 897 N‐terminal peptides were characterized (424 N‐α‐acetylated and 473 TMPP‐labelled peptides). These results allowed the precise identification of the N‐terminus of 693 unique proteins corresponding to 26% of all identified proteins. Overall, 120 already annotated processing cleavage sites were confirmed while 302 new cleavage sites were characterized. The accumulation of experimental evidence of mature N‐termini should allow increasing the knowledge of processing mechanisms and consequently also enhance cleavage sites prediction algorithms. Complete datasets have been deposited to the ProteomeXchange Consortium with identifiers PXD001521, PXD001522 and PXD001523 (http://proteomecentral.proteomexchange.org/dataset/PXD001521, http://proteomecentral.proteomexchange.org/dataset/PXD0001522 and http://proteomecentral.proteomexchange.org/dataset/PXD001523, respectively).
Gut Microbiota Contributes to the Growth of Fast-Growing Transgenic Common Carp (Cyprinus carpio L.)

Gut microbiota has shown tight and coordinated connection with various functions of its host such as metabolism, immunity, energy utilization, and health maintenance. To gain insight into whether gut microbes affect the metabolism of fish, we employed fast-growing transgenic common carp (Cyprinus carpio L.) to study the connections between its large body feature and gut microbes. Metagenome-based fingerprinting and high-throughput sequencing on bacterial 16S rRNA genes indicated that fish gut was dominated by Proteobacteria, Fusobacteria, Bacteroidetes and Firmicutes, which displayed significant differences between transgenic fish and wild-type controls. Analyses to study the association of gut microbes with the fish metabolism discovered three major phyla having significant relationships with the host metabolic factors. Biochemical and histological analyses indicated transgenic fish had increased carbohydrate but decreased lipid metabolisms. Additionally, transgenic fish has a significantly lower Bacteroidetes:Firmicutes ratio than that of wild-type controls, which is similar to mammals between obese and lean individuals. These findings suggest that gut microbiotas are associated with the growth of fast growing transgenic fish, and the relative abundance of Firmicutes over Bacteroidetes could be one of the factors contributing to its fast growth. Since the large body size of transgenic fish displays a proportional body growth, which is unlike obesity in human, the results together with the findings from others also suggest that the link between obesity and gut microbiota is likely more complex than a simple Bacteroidetes:Firmicutes ratio change.
Incremental Learning of Relational Action Rules

In the Relational Reinforcement learning framework, we propose an algorithm that learns an action model allowing to predict the resulting state of each action in any given situation. The system incrementally learns a set of first order rules: each time an example contradicting the current model (a counter-example) is encountered, the model is revised to preserve coherence and completeness, by using data-driven generalization and specialization mechanisms. The system is proved to converge by storing counter-examples only, and experiments on RRL benchmarks demonstrate its good performance w.r. t state of the art RRL systems.
Maize in Eastern and Southern Africa: 'seeds' of success in retrospect

This synthesis revisits the “maize success story” in Sub-Saharan Africa, drawing selectively from an extensive published literature about maize seed technical change and related policies. The review focuses on the countries of Kenya, Zimbabwe, Zambia, and Malawi, where maize is most important in the food economy, and refers to the period when maize became a dominant food crop through the 1990s. The term “success” is equivocal in this case, both because of the difficult of establishing the appropriate counterfactual and because some of the policies that contributed to success in one period later led to decline. While the “seeds” themselves were the result of innovative, successful maize breeding, boom periods in maize production were episodic and the public investments in the controlled markets that bolstered them were not fiscally sustainable. Since maize will remain a crucial part of the food security equation even while the agricultural economies of the region diversify, continued investments in both maize research and market institutions, some of which must be public, are essential. The most vital question, however, is where the domestic political pressure to support these investments will originate an issue related to governance.
Human papillomavirus (HPV) genotypes in an Australian sample of anal cancers

Human papillomavirus (HPV) causes most cases of anal cancers. In this study, we analyzed biopsy material from 112 patients with anal cancers in Australia for the presence of HPV DNA by the INNO LiPA HPV genotyping assay. There were 82% (92) males and 18% (20) females. The mean age at diagnosis was significantly (p = 0.006) younger for males (52.5 years) than females (66 years). HIV‐infected males were diagnosed at a much earlier mean age (48.2 years) than HIV negative (56.3 years) males (p = 0.05). HPV DNA was detected in 96.4% (108) of cases. HPV type 16 was the commonest, at 75% (81) of samples and being the sole genotype detected in 61% (66). Overall, 79% (85) of cases had at least one genotype targeted by the bivalent HPV (bHPV) vaccine, 90% (97) by the quadrivalent HPV (qHPV) vaccine and 96% (104) by the nonavalent HPV (nHPV) vaccine. The qHPV vaccine, which is now offered to all secondary school students in Australia, may prevent anal cancers in Australia. However, given the mean age of onset of this condition, the vaccine is unlikely to have a significant impact for several decades. Further research is necessary to prove additional protective effects of the nHPV vaccine.
Interfascial Spread of Injectate After Adductor Canal Injection in Fresh Human Cadavers

The adductor canal block has become a common analgesic technique in patients undergoing knee arthroplasty. Dispersion of local anesthetic outside the adductor canal through interfascial layers and blockade of smaller nerves that confer innervation to the knee could contribute to the analgesic efficacy of the adductor canal block. We studied the diffusion of local anesthetic mixed with dye after injection into the adductor canal in fresh human cadavers. In all 8 legs, injectate was found in the popliteal fossa in contact with the sciatic nerve and/or popliteal blood vessels. Interfascial spread patterns were identified.
Plants from Brazilian Cerrado with Potent Tyrosinase Inhibitory Activity

The increased amount of melanin leads to skin disorders such as age spots, freckles, melasma and malignant melanoma. Tyrosinase is known to be the key enzyme in melanin production. Plants and their extracts are inexpensive and rich resources of active compounds that can be utilized to inhibit tyrosinase as well as can be used for the treatment of dermatological disorders associated with melanin hyperpigmentation. Using in vitro tyrosinase inhibitory activity assay, extracts from 13 plant species from Brazilian Cerrado were evaluated. The results showed that Pouteria torta and Eugenia dysenterica extracts presented potent in vitro tyrosinase inhibition compared to positive control kojic acid. Ethanol extract of Eugenia dysenterica leaves showed significant (p<0.05) tyrosinase inhibitory activity exhibiting the IC50 value of 11.88 µg/mL, compared to kojic acid (IC50 value of 13.14 µg/mL). Pouteria torta aqueous extract leaves also showed significant inhibitory activity with IC50 value of 30.01 µg/mL. These results indicate that Pouteria torta and Eugenia dysenterica extracts and their isolated constituents are promising agents for skin-whitening or antimelanogenesis formulations.
Experimental Evidence on Decision-Making in Availability Service Level Agreements

As more enterprises buy information technology services, studying their underpinning contracts becomes more important. With cloud computing and outsourcing, these service level agreements (SLAs) are now often the only link between the business and the supporting IT services. This paper presents an experimental economics investigation of decision-making with regard to availability SLAs, among enterprise IT professionals. The method and the ecologically valid subjects make the study unique to date among IT service SLA studies. The experiment consisted of pairwise choices under uncertainty, and subjects (N=46) were incentivized by payments based on one of their choices, randomly selected. The research question investigated in this paper is: Do enterprise IT professionals maximize expected value when procuring availability SLAs, as would be optimal from the business point of view? The main result is that enterprise IT professionals fail to maximize expected value. Whereas some subjects do maximize expected value, others are risk-seeking, risk-averse, or exhibit nonmonotonic preferences. The nonmonotonic behavior in particular is an interesting observation, which has no obvious explanation in the literature. For a subset of the subjects (N=29), a few further hypotheses related to associations between general attitude to risk or professional experience on the one hand, and behavior in SLAs on the other hand, were investigated. No support for these associations was found. The results should be interpreted with caution, due to the limited number of subjects. However, given the prominence of SLAs in modern IT service management, the results are interesting and call for further research, as they indicate that current professional decision-making regarding SLAs can be improved. In particular, if general attitude to risk and professional experience do not impact decision-making with regard to SLAs, more extensive use of decision-support systems might be called for in order to facilitate proper risk management.
Automatic image quality improvement for videoconferencing

In videoconferencing, the image quality is significantly affected by the illumination condition. Unsatisfactory illumination conditions may lead to underexposure or overexposure of the area of interest, in particular a human face. To resolve this issue, we propose a solution to improve image quality automatically by correcting exposure and enhancing contrast. Our work is characterized by a method for automatically building a skin-color model and a novel contrast enhancement approach. Some techniques that can reduce the computational cost are also introduced. Experimental results show that obvious improvement in image quality is achieved while the computation overhead is very small. The proposed solution can be integrated into videoconferencing systems and is especially suitable for scenarios where low-complexity computing is required.