Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and Evaluation of a Cell Phone Pointing Interface for Interaction with Large Projector based Displays

The availability of mobile phones enhanced with different sensors increased the possibility of using the mobile devices in various applications in ubiquitous computing. Mobile phones can be used as interaction device with other devices such as large projected displays. In this paper we propose a design of a cell phone pointing interface based on its embedded accelerometer sensor for interaction with large projector based displays. The main idea is to use a simple hand gestures for pointing to a certain point, for object selection, for object movement or for drawing various forms on large display screen. Rigorous and systematic evaluation of the proposed interface has been conducted and its efficiency has been experimentally evaluated on various tasks. The results have shown that embedded accelerometer sensor in mobile phones in combination with a simple hand gestures are a promising approach for interaction with large display screen and that potential users see ease of use, intuitiveness and enjoyment as advantages of this interaction technique.
Interleukin-6 - A Key Regulator of Colorectal Cancer Development

Growing evidence proposes an important role for pro-inflammatory cytokines during tumor development. Several experimental and clinical studies have linked the pleiotropic cytokine interleukin-6 (IL-6) to the pathogenesis of sporadic and inflammation-associated colorectal cancer (CRC). Increased IL-6 expression has been related to advanced stage of disease and decreased survival in CRC patients. According to experimental studies, these effects are mediated through IL-6 trans-signaling promoting tumor cell proliferation and inhibiting apoptosis through gp130 activation on tumor cells with subsequent signaling through Janus kinases (JAKs) and signal transducer and activator of transcription 3 (STAT3). During recent years, several therapeutics targeting the IL-6/STAT3 pathway have been developed and pose a promising strategy for the treatment of CRC. This review discusses the molecular mechanisms and possible therapeutic targets involved in IL-6 signaling in CRC.
On error exponents in quantum hypothesis testing

In the simple quantum hypothesis testing problem for two density operators, upper bounds on the error probabilities are shown based on a key operator inequality between a density operator and a conditional expectation of it. Concerning the error exponents, the upper bounds lead to a noncommutative analog of the Hoeffding bound, which is identical with the classical counterpart if two density operators commute. The upper bounds also provide a simple proof of the direct part of the quantum Stein's lemma.
Complexity of torus bundles over the circle with monodromy (2 1, 1 1)

We find the exact values of complexity for an infinite series of 3-manifolds. Namely, by calculating hyperbolic volumes, we show that c(N_n)=2n, where $c$ is the complexity of a 3-manifold and N_n is the total space of the punctured torus bundle over S^1 with monodromy 2&1 1&1 ^n$. We also apply a recent result of Matveev and Pervova to show that c(M_n) \ge 2Cn with C\approx 0.598, where a compact manifold M_n is the total space of the torus bundle over S^1 with the same monodromy as N_n, and discuss an approach to the conjecture c(M_n)=2n+5 based on the equality c(N_n)=2n.
Experiments with linear feature extraction in speech recognition

In this paper we investigate Linear Discriminant Analysis (LDA) for the TI connected digit recognition task (TI task) and the Wall Street Journal large vocabulary recognition task (WSJ task). In addition to previous variants of LDA implementations, we avoided the explicit incorporation of derivatives in the acoustic vector. Instead a sliding window without derivatives was used. This large-sized vector was then taken to extract the features by an LDA transformation. Tests for this feature generation were performed both for Laplacian and Gaussian densities.
Sparsity in Passive Observations of Address Liveness ( extended ) ISI-TR-2016-710 July 2016

Full allocation of IPv4 addresses has prompted interest in measuring address liveness, first with active probing, and recently with the addition of passive observation. While prior work has investigated how to increase coverage by combining multiple sources, this paper explores what factors affect a passive observer’s view. All passive monitors are sparse, seeing only a part of the Internet. We seek to understand how different types of sparsity impact observation quality: the interests of external hosts and the hosts within the observed network, the temporal limitations on the observation duration, and coverage challenges to observe all traffic for a given target or a given vantage point. We study sparsity through inverted analysis — a new approach where we use passive observations at three end networks to infer what of these networks would be seen by virtual monitors, located at all traffic destinations. We show that visibility provided by monitors is heavy-tailed—interest sparsity means popular monitors see a great deal, while 99% see very little. We find that traffic is mostly bipartite, with greater visibility between client-networks and server-networks, than within each group. Finally, we find that popular monitors are robust to temporal and coverage sparsity, but these sparsities greatly reduce power of monitors with initially low visibility.
Catheter-Based Renal Nerve Ablation and Centrally Generated Sympathetic Activity in Difficult-to-Control Hypertensive Patients: Prospective Case Series

Endovascular renal nerve ablation has been developed to treat resistant hypertension. In addition to lowering efferent renal sympathetic activation, the intervention may attenuate central sympathetic outflow through decreased renal afferent nerve traffic, as evidenced by a recent case report. We tested the hypothesis in 12 nonpreselected patients with difficult-to-control hypertension (aged 45–74 years) admitted for renal nerve ablation. All patients received ≥3 antihypertensive medications at full doses, including a diuretic. Electrocardiogram, respiration, brachial and finger arterial blood pressure, and muscle sympathetic nerve activity were recorded before and 3 to 6 months after renal nerve ablation. Heart rate and blood pressure variability were analyzed in the time and frequency domain. Pharmacological baroreflex slopes were determined using the modified Oxford bolus technique. Resting heart rate was 61±3 bpm before and 58±2 bpm after ablation (P=0.4). Supine blood pressure was 157±7/85±4 mm Hg before and 157±6/85±4 mm Hg after ablation (P=1.0). Renal nerve ablation did not change resting muscle sympathetic nerve activity (before, 34±2 bursts per minute; after, 32±3 bursts per minute P=0.6), heart rate variability, or blood pressure variability. Pharmacological baroreflex control of heart rate and muscle sympathetic nerve activity did not change. We conclude that reduced central sympathetic inhibition may be the exception rather than the rule after renal nerve ablation in unselected patients with difficult-to-control arterial hypertension.
Cholesterol-lowering effect of soyabean lecithin in normolipidaemic rats by stimulation of biliary lipid secretion

Abstract The purpose of the present study was to assess the role of the liver in the plasma-cholesterol-lowering effect of soyabean lecithin. Normolipidaemic rats were fed on lecithin-enriched or control diets with the same amount of protein. The lecithin diets contained 200 g/kg high-fat commercial semi-purified soyabean lecithin (230 g/kg total lipids as soyabean phosphatidylcholine) or 200 g/kg high-fat purified soyabean lecithin (930 g/kg total lipids as soyabean phosphatidylcholine). The control diets were a low-fat diet (40 g fat/kg) and a high-fat triacylglycerol-rich diet (200 g fat/kg). The high-fat diets were isoenergetic. The cholesterol-lowering effect of the lecithin-enriched diets was associated with significantly lower levels of plasma total- and HDL-cholesterol and significantly higher levels of bile phosphatidylcholine (PC), bile salts and cholesterol. These findings suggest that the liver plays a major role in the reduction of plasma cholesterol, the increased biliary lipid being provided by both HDL and the hepatic microsomal pools of PC and cholesterol.
Artificial Muscles for Humanoid Robots

1. The question of actuator choice for humanoid robots It is important to recall that humanoid robot technology derives from the technology of industrial robots. It is obvious that the developments of bipedal robots such as the integration of robot-upper limbs to com plex anthropomorphic structures have benefited from progress in mechanical structures, sensors and actuators used in industrial robot-arms. A direct link is sometimes made between the technology of redundant robot-arms and humanoid robots as underlined in some technical documents of the Japanese AIST where it clearly appears that the HRP2 humanoid robot upper limb is directly derived from the Mitsubshi PA10 7R industrial robot-arm. Due to its high number of degrees of freedom in comparison to i ndustrial robots, a humanoid robot requires great compactness of all actuator and sensor components. This is why we believe that the harmonic drive technology associated with direct current electric motor technology has played a non-negligible part in humanoid robot development. The DC actuator offers the great advantage of being a straightforwar d technology, associated with simple and well-known physical models, its integration into mobile robots benefits from new developments in embedded batteries. However, its low maximum-torque-onmass and maximum-torque-on- volume ratios are a serious drawback for its use in direct drive apparatuses. On the other hand, the ability of electric motors to generate very high velocities in comparison with moderate jointed velocities needed by industrial robot-arms and more by jointed anthropomorphic limbs, gives the possibility of using high ratio speed reducers to amplify motor-torque. Moreover, the choice of a high ratio speed reducer offers the advantage of masking inertial perturbations such as external torque perturbations. The technical achievement of such ratios induces specific mechanical difficulties due to the bulkiness of successive gears; harmonic drive technology – represented for example by Harmonic Drive AG – resolves this problem in a very elegant manner: the harmonic drive and the actuator fit together without excessive increase in mass and volume in comparison with the actuator alone. It can be considered that most of today’s humanoid robots are actuated by DC motors with harmonic drives (this actuation mode is mentioned, for example, by Honda from its first paper about the P2 robot onwards (Hirai et al., 1998) and then in the official ASIMO web site, as well as in papers concerning other Japanese and European humanoid robots). But if this technology simplifies actuator mechanical integration and leads to the use of simple joint linear control, despite the highly non-linear character of robot dynamics, it is well-known that the use of a speed reducer multiplies the
A Fast and Accurate Vietnamese Word Segmenter

We propose a novel approach to Vietnamese word segmentation. Our approach is based on the Single Classification Ripple Down Rules methodology (Compton and Jansen, 1990), where rules are stored in an exception structure and new rules are only added to correct segmentation errors given by existing rules. Experimental results on the benchmark Vietnamese treebank show that our approach outperforms previous state-of-the-art approaches JVnSegmenter, vnTokenizer, DongDu and UETsegmenter in terms of both accuracy and performance speed. Our code is open-source and available at: this https URL
Transcription factors of the alternative NF-κB pathway are required for germinal center B-cell development

Significance In many human B-cell cancers, a complex signaling cascade called NF-κB is abnormally activated by genetic mutations. The uncontrolled activity of NF-κB because of genetic mutations promotes the formation of B-cell tumors. The NF-κB cascade is comprised of two distinct pathways. We here define the role of one of these routes, called the alternative NF-κB pathway, in the normal cells from which these B-cell tumors are derived, namely germinal center (GC) B cells or plasma cells (PCs). We found that the inactivation of the alternative NF-κB pathway led to the loss of GC B cells and impaired PC development. Understanding the role of this pathway in normal cells may provide important insights into how aberrant activation promotes B-cell tumors. The NF-κB signaling cascade relays external signals essential for B-cell growth and survival. This cascade is frequently hijacked by cancers that arise from the malignant transformation of germinal center (GC) B cells, underscoring the importance of deciphering the function of NF-κB in these cells. The NF-κB signaling cascade is comprised of two branches, the canonical and alternative NF-κB pathways, mediated by distinct transcription factors. The expression and function of the transcription factors of the alternative pathway, RELB and NF-κB2, in late B-cell development is incompletely understood. Using conditional deletion of relb and nfkb2 in GC B cells, we here report that ablation of both RELB and NF-κB2, but not of the single transcription factors, resulted in the collapse of established GCs. RELB/NF-κB2 deficiency in GC B cells was associated with impaired cell-cycle entry and reduced expression of the cell-surface receptor inducible T-cell costimulator ligand that promotes optimal interactions between B and T cells. Analysis of human tonsillar tissue revealed that plasma cells and their precursors in the GC expressed high levels of NF-κB2 relative to surrounding lymphocytes. Accordingly, deletion of nfkb2 in murine GC B cells resulted in a dramatic reduction of antigen-specific antibody-secreting cells, whereas deletion of relb had no effect. These results demonstrate that the transcription factors of the alternative NF-κB pathway control distinct stages of late B-cell development, which may have implications for B-cell malignancies that aberrantly activate this pathway.
Antioxydation And Cell Migration Genes Are Identified as Potential Therapeutic Targets in Basal-Like and BRCA1 Mutated Breast Cancer Cell Lines

Basal-like breast cancers are among the most aggressive cancers and effective targeted therapies are still missing. In order to identify new therapeutic targets, we performed Methyl-Seq and RNA-Seq of 10 breast cancer cell lines with different phenotypes. We confirmed that breast cancer subtypes cluster the RNA-Seq data but not the Methyl-Seq data. Basal-like tumor hypermethylated phenotype was not confirmed in our study but RNA-Seq analysis allowed to identify 77 genes significantly overexpressed in basal-like breast cancer cell lines. Among them, 48 were overexpressed in triple negative breast cancers of TCGA data. Some molecular functions were overrepresented in this candidate gene list. Genes involved in antioxydation, such as SOD1, MGST3 and PRDX or cadherin-binding genes, such as PFN1, ITGB1 and ANXA1, could thus be considered as basal like breast cancer biomarkers. We then sought if these genes were linked to BRCA1, since this gene is often inactivated in basal-like breast cancers. Nine genes were identified overexpressed in both basal-like breast cancer cells and BRCA1 mutated cells. Amongst them, at least 3 genes code for proteins implicated in epithelial cell migration and epithelial to mesenchymal transition (VIM, ITGB1 and RhoA). Our study provided several potential therapeutic targets for triple negative and BRCA1 mutated breast cancers. It seems that migration and mesenchymal properties acquisition of basal-like breast cancer cells is a key functional pathway in these tumors with a high metastatic potential.
The Role of Ekman Currents, Geostrophy, and Stokes Drift in the Accumulation of Floating Microplastic

Abstract Floating microplastic in the oceans is known to accumulate in the subtropical ocean gyres, but unclear is still what causes that accumulation. We investigate the role of various physical processes, such as surface Ekman and geostrophic currents, surface Stokes drift, and mesoscale eddy activity, on the global surface distribution of floating microplastic with Lagrangian particle tracking using GlobCurrent and WaveWatch III reanalysis products. Globally, the locations of microplastic accumulation (accumulation zones) are largely determined by the Ekman currents. Simulations of the North Pacific and North Atlantic show that the locations of the modeled accumulation zones using GlobCurrent Total (Ekman+Geostrophic) currents generally agree with observed microplastic distributions in the North Pacific and with the zonal distribution in the North Atlantic. Geostrophic currents and Stokes drift do not contribute to large‐scale microplastic accumulation in the subtropics, but Stokes drift leads to increased microplastic transport to Arctic regions. Since the WaveWatch III Stokes drift and GlobCurrent Ekman current data sets are not independent, combining Stokes drift with the other current components leads to an overestimation of Stokes drift effects and there is therefore a need for independent measurements of the different ocean circulation components. We investigate whether windage would be appropriate as a proxy for Stokes drift but find discrepancies in the modeled direction and magnitude. In the North Pacific, we find that microplastic tends to accumulate in regions of relatively low eddy kinetic energy, indicating low mesoscale eddy activity, but we do not see similar trends in the North Atlantic.
An Integrated Regulatory Network Reveals Pervasive Cross-Regulation among Transcription and Splicing Factors

Traditionally the gene expression pathway has been regarded as being comprised of independent steps, from RNA transcription to protein translation. To date there is increasing evidence of coupling between the different processes of the pathway, specifically between transcription and splicing. To study the interplay between these processes we derived a transcription-splicing integrated network. The nodes of the network included experimentally verified human proteins belonging to three groups of regulators: transcription factors, splicing factors and kinases. The nodes were wired by instances of predicted transcriptional and alternative splicing regulation. Analysis of the network indicated a pervasive cross-regulation among the nodes; specifically, splicing factors are significantly more connected by alternative splicing regulatory edges relative to the two other subgroups, while transcription factors are more extensively controlled by transcriptional regulation. Furthermore, we found that splicing factors are the most regulated of the three regulatory groups and are subject to extensive combinatorial control by alternative splicing and transcriptional regulation. Consistent with the network results, our bioinformatics analyses showed that the subgroup of kinases have the highest density of predicted phosphorylation sites. Overall, our systematic study reveals that an organizing principle in the logic of integrated networks favor the regulation of regulatory proteins by the specific regulation they conduct. Based on these results, we propose a new regulatory paradigm postulating that gene expression regulation of the master regulators in the cell is predominantly achieved by cross-regulation.
Rice, weeds and shifting cultivation in a tropical rain forest : a study of vegetation dynamics

The study deals with the rain forest area in south-west Cote d'lvoire (Tai National Park). Descriptions are given of the area's history, agricultural practices, geology, geomorphology, soils, flora and vegetation. The shifting cultivation system based on upland rice was studied as it is practiced without land shortage and under constraints. Possible adaptations of the system to the increasing population pressure have been tested on the fields of local farmers. Special attention was paid to the dynamics of the weed population and to the competition between rice and weeds. The classifications of primary forest, secondary forest and field vegetations are based on their complete floristic composition and was carried out by tabular comparison of plot-data.
Expressing Security Properties Using Selective Interleaving Functions

McLean's notion of Selective Interleaving Functions (SIFs) is perhaps the best-known attempt to construct a framework for expressing various security properties. We examine the expressive power of SIFs carefully. We show that SIFs cannot capture nondeducibility on strategies (NOS). We also prove that the set of security properties expressed with SIFs is not closed under conjunction, from which it follows that separability is strictly stronger than double generalized noninterference. However, we show that if we generalize the notion of SIF in a natural way, then NOS is expressible, and the set of security properties expressible by generalized SIFs is closed under conjunction.
A prospective comparison of four techniques for measuring platelet‐associated IgG

We describe a prospective study comparing four different assays for PAIgG. Platelets from patients with a variety of thrombocytopenic disorders were collected into ACD, washed, and the PAIgG then measured using three assays for surface PAIgG. These included: (a) a direct binding assay using 125I‐monoclonal anti‐IgG (MoAb); (b) a direct binding assay using 125I‐staphylococcal protein A (SPA); and (c) a two‐stage assay. PAIgG also was measured using an assay for ‘total’ PAIgG following platelet lysis. The mean ± SD number of molecules of IgG per platelet on washed platelets from 29 healthy, non‐thrombocytopenic controls was: 86 ± 80 (125I‐MoAb); 94 ± 96 (125I‐SPA); 3520 ± 1890 (two‐stage surface assay); and 10 850 ± 3720 (total PAIgG). A total of 62 different patients with idiopathic thrombocytopenic purpura or thrombocytopenia complicating systematic lupus erythematosus, and 73 different patients with‘non‐immune’ thrombocytopenia, were tested using each of the four assays. These ‘non‐immune’ thrombocytopenic patients included patients with carcinoma, septicaemia, pre‐eclampsia, chronic leukaemia, thrombotic thrombocytopenic purpura, haemolytic uraemic syndrome, acute leukaemia and myelodysplasia. All four essays gave similar results for both the immune and non‐immune thrombocytopenic patients. The sensitivity of the assays for the most severely thrombocytopenic patients with immune thrombocytopenia was: MoAb 60%; SPA 88%; two‐stage 82%; and‘total’ PAIgG 88%. The specificity of the four assays in the non‐immune thrombocytopenic patients was 57%‘total’ PAIgG; 63% two‐stage surface; 25% SPA; 38% MoAb. There was no quantitative cut‐off point that could be used to segregate the non‐immune thrombocytopenic patients from the immune thrombocytopenic patients. These results indicate that all of these assays share a similar high sensitivity but low specificity for ITP.
On fourier series of Jacobi-Sobolev orthogonal polynomials

where c E (1,00) and M, N are non negative constants such that M + N > O. The main purpose of this paper is to study the behaviour of the Fourier series in terms of the polynomials associated to the Sobolev inner product. For an appropriate function f, we prove here that the Fourier-Sobolev series converges to f on the interval (-I, I) as well as to f( c) and the derivative of the series converges to f' (c). The term appropriate means here, in general, the same as we need for a function f(x) in order to have convergence for the series of f(x) associated to the standard inner product given by the measure J.l. No additional conditions are needed.