Miracle-dz/UniFAR-FTUs huggingface dataset:
Dose intensity of chemotherapy in patients with relapsed Hodgkin's lymphoma.

PURPOSE High-dose chemotherapy (HDCT) followed by autologous stem-cell transplantation (PBSCT) has become the standard treatment for patients with relapsed Hodgkin's lymphoma (HL). The intensity of treatment needed is unclear. This European intergroup study evaluated the impact of sequential high-dose chemotherapy (SHDCT) before myeloablative therapy. PATIENTS AND METHODS Patients with histologically confirmed, relapsed HL were treated with two cycles of dexamethasone, cytarabine, and cisplatin, and those without disease progression were randomly assigned. In the standard arm (A), patients received myeloablative therapy with carmustine, BEAM (carmustine, etoposide, cytarabine, and melphalan) followed by PBSCT. Patients in the experimental arm (B) also received sequential cyclophosphamide, methotrexate, and etoposide in high-doses before BEAM. Freedom from treatment failure (FFTF) was the primary end point. Remission rates, overall survival (OS), and toxicity of treatment were secondary end points. RESULTS From a total of 284 patients included, 241 responding patients were randomly assigned after two cycles of dexamethasone, cytarabine, and cisplatinum. Patients treated in arm B had longer treatment duration and experienced more toxicity and protocol violations (P < .05). Mortality was similar in both arms (20% and 18%). With a median observation time of 42 months, there was no significant difference in terms of FFTF (P = .56) and OS (P = .82) between arms. FFTF at 3 years was 62% (95% CI, 56% to 68%) and OS was 80% (95% CI, 75% to 85%). Patients with stage IV, early relapse, multiple relapse, anemia, or B symptoms had a higher risk of recurrence (P < .001). CONCLUSION Compared with conventional high-dose chemotherapy, additional SHDCT is associated with more adverse effects and does not improve the prognosis of patients with relapsed HL.
An alternative Ca2+‐dependent mechanism of neuroprotection by the metalloporphyrin class of superoxide dismutase mimetics

This study challenges the conventional view that metalloporphyrins protect cultured cortical neurons in models of cerebral ischemia by acting as intracellular catalytic antioxidants [superoxide dismutase (SOD) mimetics]. High SOD‐active MnIIIporphyrins meso‐substituted with N, N′‐dimethylimidazolium or N‐alkylpyridinium groups did not protect neurons against oxygen‐glucose deprivation (OGD), although lower SOD‐active and ‐inactive para isomers protected against N‐methyl‐d‐aspartate (NMDA) exposure. MnIIImeso‐tetrakis(4‐benzoic acid)porphyrin (MnIIITBAP), as well as SOD‐inactive metalloTBAPs and other phenyl ring‐ or β‐substituted metalloporphyrins that contained redox‐insensitive metals, protected cultures against OGD and NMDA neurotoxicity. Crucially, neuroprotective metalloporphyrins suppressed OGD‐ or NMDA‐induced rises in intracellular Ca2+ concentration in the same general rank order as observed for neuroprotection. Results from paraquat toxicity, intracellular fluorescence quenching, electrophysiology, mitochondrial Ca2+, and spontaneous synaptic activity experiments suggest a model in which metalloporphyrins, acting at the plasma membrane, protect neurons against OGD by suppressing postsynaptic NMDA receptor‐mediated Ca2+ rises, thereby indirectly preventing accumulation of neurotoxic mitochondrial Ca2+ levels. Though neuroprotective in a manner not originally intended, SOD‐inactive metalloporphyrins may represent promising therapeutic agents in diseases such as cerebral ischemia, in which Ca2+ toxicity is implicated. Conventional syntheses aimed at improving the catalytic antioxidant capability and/or intracellular access of metalloporphyrins may not yield improved efficacy in some disease models.
Fluorescent Protein Aided Insights on Plastids and their Extensions: A Critical Appraisal

Multi-colored fluorescent proteins targeted to plastids have provided new insights on the dynamic behavior of these organelles and their interactions with other cytoplasmic components and compartments. Sub-plastidic components such as thylakoids, stroma, the inner and outer membranes of the plastid envelope, nucleoids, plastoglobuli, and starch grains have been efficiently highlighted in living plant cells. In addition, stroma filled membrane extensions called stromules have drawn attention to the dynamic nature of the plastid and its interactions with the rest of the cell. Use of dual and triple fluorescent protein combinations has begun to reveal plastid interactions with mitochondria, the nucleus, the endoplasmic reticulum and F-actin and suggests integral roles of plastids in retrograde signaling, cell to cell communication as well as plant-pathogen interactions. While the rapid advances and insights achieved through fluorescent protein based research on plastids are commendable it is necessary to endorse meaningful observations but subject others to closer scrutiny. Here, in order to develop a better and more comprehensive understanding of plastids and their extensions we provide a critical appraisal of recent information that has been acquired using targeted fluorescent protein probes.
Improving flash-based disk cache with Lazy Adaptive Replacement

The increasing popularity of flash memory has changed storage systems. Flash-based solid state drive(SSD) is now widely deployed as cache for magnetic hard disk drives(HDD) to speed up data intensive applications. However, existing cache algorithms focus exclusively on performance improvements and ignore the write endurance of SSD. In this paper, we proposed a novel cache management algorithm for flash-based disk cache, named Lazy Adaptive Replacement Cache(LARC). LARC can filter out seldom accessed blocks and prevent them from entering cache. This avoids cache pollution and keeps popular blocks in cache for a longer period of time, leading to higher hit rate. Meanwhile, LARC reduces the amount of cache replacements thus incurs less write traffics to SSD, especially for read dominant workloads. In this way, LARC improves performance and extends SSD lifetime at the same time. LARC is self-tuning and low overhead. It has been extensively evaluated by both trace-driven simulations and a prototype implementation in flashcache. Our experiments show that LARC outperforms state-of-art algorithms and reduces write traffics to SSD by up to 94.5% for read dominant workloads, 11.2-40.8% for write dominant workloads.
Racial disparities in cancer survival among randomized clinical trials patients of the Southwest Oncology Group.

BACKGROUND Racial disparities in cancer outcomes have been observed in several malignancies. However, it is unclear if survival differences persist after adjusting for clinical, demographic, and treatment variables. Our objective was to determine whether racial disparities in survival exist among patients enrolled in consecutive trials conducted by the Southwest Oncology Group (SWOG). METHODS We identified 19 457 adult cancer patients (6676 with breast, 2699 with lung, 1244 with colon, 1429 with ovarian, and 1843 with prostate cancers; 1291 with lymphoma; 2067 with leukemia; and 2208 with multiple myeloma) who were treated on 35 SWOG randomized phase III clinical trials from October 1, 1974, through November 29, 2001. Patients were grouped according to studies of diseases with similar histology and stage. Cox regression was used to evaluate the association between race and overall survival within each disease site grouping, controlling for available prognostic factors plus education and income, which are surrogates for socioeconomic status. Median and ten-year overall survival estimates were derived by the Kaplan-Meier method. All statistical tests were two-sided. RESULTS Of 19 457 patients registered, 2308 (11.9%, range = 3.9%-21.6%) were African American. After adjustment for prognostic factors, African American race was associated with increased mortality in patients with early-stage premenopausal breast cancer (hazard ratio [HR] for death = 1.41, 95% confidence interval [CI] = 1.10 to 1.82; P = .007), early-stage postmenopausal breast cancer (HR for death = 1.49, 95% CI = 1.28 to 1.73; P < .001), advanced-stage ovarian cancer (HR for death = 1.61, 95% CI = 1.18 to 2.18; P = .002), and advanced-stage prostate cancer (HR for death = 1.21, 95% CI = 1.08 to 1.37; P = .001). No statistically significant association between race and survival for lung cancer, colon cancer, lymphoma, leukemia, or myeloma was observed. Additional adjustments for socioeconomic status did not substantially change these observations. Ten-year (and median) overall survival rates for African American vs all other patients were 68% (not reached) vs 77% (not reached), respectively, for early-stage, premenopausal breast cancer; 52% (10.2 years) vs 62% (13.5 years) for early-stage, postmenopausal breast cancer; 13% (1.3 years) vs 17% (2.3 years) for advanced ovarian cancer; and 6% (2.2 years) vs 9% (2.7 years) for advanced prostate cancer. CONCLUSIONS African American patients with sex-specific cancers had worse survival than white patients, despite enrollment on phase III SWOG trials with uniform stage, treatment, and follow-up.
Long-term chronic baroreflex activation: persistent efficacy in patients with heart failure and reduced ejection fraction

Aims: Baroreflex activation therapy (BAT) has recently been shown to reduce muscle sympathetic nerve activity and hospitalization rate while improving clinical variables through 6 months of therapy in patients with heart failure and reduced ejection fraction (HFrEF). The objective of the present study is to extend the information on this patient cohort over a long-term follow-up. Methods and results: Eleven patients were enrolled in the study and presented with optimized, stable medical therapy, New York Heart Association Class III HFrEF with left ventricular ejection fraction 40% or less, impaired functional capacity and no active cardiac resynchronization therapy. For the present report, muscle sympathetic nerve activity, baroreflex sensitivity data and hospitalization rate together with standard clinical data were collected at 12 and 21.5 ± 4.2 months following BAT activation. Two patients died during long-term follow-up. The remaining nine patients maintained the improvements observed at 6 months, including reduced sympathetic activity and rates of hospitalization. Conclusion: BAT provides long-term chronic reductions in sympathetic activity and utilization of hospital resources in patients with HFrEF. General clinical presentation, quality of life and functional capacity are likewise improved and maintained. The temporal association of BAT with sympathetic drive diminution and improvement in objective clinical measures suggests a cause-and-effect relationship that will be verified in future randomized controlled trials of outcome.
A Procedure to Estimate Relation in a Balanced Scorecard

A balanced scorecard (BSC) is more than a business model because it moves performance measurement to performance management. It consists of performance indicators which are inter-related. Some relations are hard to find, like soft skills. We propose a procedure to fully specify these relations. Three types of relationships will be considered. For the function types inverse functions exist. Each equation can be solved uniquely for variables at the right hand side. By generating noisy data in a MC simulation we can specify function type and estimate the respected parameters. An example will illustrate our procedure and the corresponding results.
The use of internet-based social media as a tool in enhancing student’s learning experiences in biological sciences

This study explored the use of social media as a tool in enhancing student’s learning experiences, by using online instruction as a supplement to a face-to-face general education course, such as biological sciences. Survey data were collected from 186 students who were enrolled in a Biological Sciences course. The course was taught in a blended format using Facebook and Edmodo online social networks. A four point Likert scale was used to interpret the data collected. Findings indicated that, when traditional face-to-face instruction was combined with online components, students’ learning was enhanced. Findings from this study indicate that students had better experience, better engagement, and appreciated both the social learning experience gave by the online social network. Results revealed that students through student-student interaction and student-teacher interaction enhance their own experiences and improved their learning ability. The findings were used as bases in developing new practices and methodologies involving social networking tools for learning. Moreover, findings were used to design a blended format syllabus and blended learning guidelines. DOI: 10.18870/hlrc.v3i4. 170
Spectrum Sensing Techniques in Cognitive Radio Communications

In this paper, we review some of the recent patents on spectrum sensing techniques for cognitive radio (CR) applications. The presented patents are categorized under: 1) spectrum sensing algorithms and architectures, 2) spectrum sensing and data communication and 3) cooperative spectrum sensing. The presented patents include special sensing algorithms that are based on the multi-resolution spectrum sensing (MRSS) approach, which ensures reliability of the spectrum sensing in wireless RF environments. We also discuss a CR patent that includes multiple RF chains to perform simultaneous cognitive tasks. Several patents that consider cooperative sensing are also presented as a solution to the hidden terminal problem inherent in wireless networks. We review the advantages and disadvantages of the presented patents and propose future directions for developing spectrum sensing techniques for CR’s.
They Still Use Some of Their Past: Historical Salience in Elementary Children's Chronological Thinking.

Fifty‐eight students at seven grade levels (kindergarten through sixth) from three population groups (urban, suburban and rural) were presented with the task of chronologically ordering a set of nine historical pictures and ‘thinking aloud’ about the task. The results of this study provide increased evidence regarding the kind and sources of children's historical knowledge, and how they deploy that knowledge. The most accessible historical knowledge for early and middle grade children apparently relates to changes in material culture and the patterns of everyday life. It appears, too, that the intertexts that inform children's historical understanding, especially prior to fourth grade, provide better information about material culture than about other aspects of change over time. In addition, some children at all grade levels linked history to such sociocultural issues as race and gender. Finally, by fifth grade, children were learning a new reference system that consisted of specific eras (Colonial, Revo.
Generalizing GlOSS to Vector-Space Databases and Broker Hierarchies

As large numbers of text databases have become available on the Internet, it is getting harder to locate the right sources for given queries. In this paper we present gGlOSS, a generalized Glossary-Of-Servers Server, that keeps statistics on the available databases to estimate which databases are the potentially most useful for a given query. gGlOSS extends our previous work, which focused on databases using the boolean model of document retrieval, to cover databases using the more sophisticated vector-space retrieval model. We evaluate our new techniques using real-user queries and 53 databases. Finally, we further generalize our approach by showing how to build a hierarchy of gGlOSS brokers. The top level of the hierarchy is so small it could be widely replicated, even at end-user workstations.
Dilemmas in Prenatal Chromosomal Diagnosis Revealed Through a Single Center's 30 Years' Experience and 90,000 Cases

Introduction: The aim of this article is to provide a perspective of prenatal chromosomal diagnosis (PCD) derived from a single center's evolving experience from ∼90,000 consecutive prenatal cases and to highlight important issues and current dilemmas. Materials and Methods: Prenatal cases in this study (1985-2013) were referred for various indications, and PCD was performed by standard karyotype in 84,255 cases, multiplex ligation-dependent probe amplification (MLPA) panel in 3,010 cases and standalone array comparative genomic hybridization (aCGH) in 3,122 cases. Results: Classic karyotype revealed 1.7 and 7.9% of pathological cases in amniotic fluid and CVS samples, respectively, with common aneuploidies accounting for 59.6 and 64.3% of the total abnormal. Molecular approaches increased the diagnostic yield by 0.6% for MLPA and 1.6% for aCGH, uncovering pathogenic chromosomal abnormalities undetectable by karyotype analysis. Conclusions: Current molecular diagnostic capabilities and the recent introduction of noninvasive prenatal testing (NIPT) point to one current major dilemma in PCD, with serious implications in genetic counseling, relating on the one hand to reaping the benefits from the high detection rate afforded through aCGH but accepting an invasive risk, and on the other hand, offering a lower detection rate practically only for Down syndrome, with minimal invasive risk.
A Risk Sensitive Estimator for Nonlinear Problems using the Adaptive Grid Method

An Adaptive Grid Method based on the well-known point-mass approximation has been developed for computation of risk-sensitive state estimates in non-linear non-Gaussian problems. Risk-sensitive estimators, believed to have increased robustness compared to their risk neutral counterparts, admit closed form expressions only for a very limited class of models including linear Gaussian models. The Extended Risk-Sensitive Filter (ERSF) which uses an EKF-like approach fails to take care of non-Gaussian problems or severe non-linearities. Recently, a particle-filter based approach has been proposed for extending the range of applications of risk-sensitive techniques. The present authors have developed the adaptive grid risk-sensitive filter (AGRSF), which was partially motivated by the need to validate the particle filter based risk-sensitive filter and uses a set of heuristics for the adaptive choice of grid points to improve the numerical efficiency. The AGRSF has been cross-validated against closed-form solutions for the linear Gaussian case and against the risk-sensitive particle filter (RSPF) for fairly severe non-linear problems which create a multi-modal posterior distribution. Root mean square error and computational cost of the AGRSF and the RSPF have been compared.
Corporate Character, Corporate Virtues

This paper extends previous discussions of corporate character and corporate virtues. By drawing particularly on the work of Alasdair MacIntyre, it offers a perspective on context-dependent categories of the virtues. It then provides a philosophically grounded framework which enables a discussion of which virtues are required for business organizations to qualify as virtuous. It offers a preliminary taxonomy of such corporate virtues and provides a revised definition of corporate character.
Tratamiento ambulatorio grupal para dependientes de cocaína combinando terapia cognitivo conductual y entrevista motivacional

Ambulatory group treatment for cocaine dependent patients combining cognitive behavioral therapy and motivational interviewing. Psychological interventions in cocaine dependent patients have demonstrated efficacy. Remarkable approaches are Contingency Management (CM) and Cognitive Behavioral Therapy (CBT). Lack of treatment adherence is the most important limitation. Motivational Interview (MI) has been shown to be an adherence enhancer. The objective of this study is to evaluate retention and abstinence in a combined CM and CBT group treatment in patients who have reached maintenance stage according to Prochaska and DiClemente's transtheoretical model (1982). Therefore, a longitudinal study was carried out with cocaine dependent patients with or without concomitant mental health disease. A 12-session open group was conducted weekly. Nineteen patients were included (78.9% men, mean age 36.6 years), 95% consumed intranasally and 47% had another psychiatric comorbidity. Treatment retention was 84%. During treatment and the first month of follow-up, all patients remained abstinent whereas at three months, 3 patients relapsed. These data confirm that using combined CM and CBT group therapy in cocaine dependents undergoing maintenance treatment enhances adherence and is effective to achieve abstinence.
A Systematic Analysis of 2 Monoisocentric Techniques for the Treatment of Multiple Brain Metastases

Background: In this treatment planning study, we compare the plan quality and delivery parameters for the treatment of multiple brain metastases using 2 monoisocentric techniques: the Multiple Metastases Element from Brainlab and the RapidArc volumetric-modulated arc therapy from Varian Medical Systems. Methods: Eight patients who were treated in our institution for multiple metastases (3-7 lesions) were replanned with Multiple Metastases Element using noncoplanar dynamic conformal arcs. The same patients were replanned with the RapidArc technique in Eclipse using 4 noncoplanar arcs. Both techniques were designed using a single isocenter. Plan quality metrics (conformity index, homogeneity index, gradient index, and R50%), monitor unit, and the planning time were recorded. Comparison of the Multiple Metastases Element and RapidArc plans was performed using Shapiro-Wilk test, paired Student t test, and Wilcoxon signed rank test. Results: A paired Wilcoxon signed rank test between Multiple Metastases Element and RapidArc showed comparable plan quality metrics and dose to brain. Mean ± standard deviation values of conformity index were 1.8 ± 0.7 and 1.7 ± 0.6, homogeneity index were 1.3 ± 0.1 and 1.3 ± 0.1, gradient index were 5.0 ± 1.8 and 5.1 ± 1.9, and R50% were 4.9 ± 1.8 and 5.0 ± 1.9 for Multiple Metastases Element and RapidArc plans, respectively. Mean brain dose was 2.3 and 2.7 Gy for Multiple Metastases Element and RapidArc plans, respectively. The mean value of monitor units in Multiple Metastases Element plan was 7286 ± 1065, which is significantly lower than the RapidArc monitor units of 9966 ± 1533 (P < .05). Conclusion: For the planning of multiple brain lesions to be treated with stereotactic radiosurgery, Multiple Metastases Element planning software produced equivalent conformity, homogeneity, dose falloff, and brain V12 Gy but required significantly lower monitor units, when compared to RapidArc plans.
The Suitability of Computer-Based Training for Workers with Limited Formal Education: A Case Study from the Us Agricultural Sector

The suitability of computer-based instruction (CBI) for workers with limited education was evaluated in an Hispanic orchard workforce that reported little computer experience and 5.6 mean years of formal education. Ladder safety training was completed by employees who rated the training highly (effect size [d_gain]=5.68), and their knowledge of ladder safety improved (d_gain=1.45). There was a significant increase (p
Detecting Nonlinearities In Speech Sounds Using The Bicoherence

A signal property called quadratic phase coupling (QPC) is the signature of a quadratically nonlinear signal production mechanism, and tools from the eld of higher-order statistics (HOS) can be used to detect this property. This paper describes an investigation into the use of a HOS tool called the bicoherence for detecting QPC in continuant speech signals. A detector for QPC is described, and applied to a number of speech sounds from a specially-recorded database. The results are consistent with the hypotheses that unvoiced fricatives are Gaussian, and that voiced continuants (vowels, voiced fricatives and nasals) do not exhibit QPC. Therefore it seems that quadratic models of speech signals are unlikely to ooer improvements over existing, linear, models.