Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Social Media Branding on Developing Brand Advocates for Start-Ups

Organizations are realizing the importance of social media and social networking sites as a communication channel for their brands. Startups, which are new small ventures, face many challenges to prosper in today's fast-paced economy. This research focuses on the challenge of building brand advocacy against the start-ups' low brand awareness and limited financing capabilities. Brand advocacy is defined as the extent to which consumers recommend the brand to their community. It is mainly characterized by high brand loyalty and strong positive electronic word of mouth. This research aims to explore the drivers of brand advocacy on social media in case of startups. The results of the will serve as the input for the second phase which follows a quantitative approach in which a survey will be undertaken to determine first, the relationship between the variables validated in the first phase and brand advocacy mediated by brand loyalty and electronic word of mouth, and second, test for demographics differences in this relationship.
Protection against singlet oxygen, the main actor of sebum squalene peroxidation during sun exposure, using Commiphora myrrha essential oil

Squalene is a component of sebum. Both are directly exposed to the external environment and play a key role in skin physiology. They are particularly prone to photo oxidation during sun exposure. We studied the impact of two types of antioxidant on sebum squalene peroxidation by UV irradiation. The first type is free radical scavenger (Butyl hydroxyl toluene and an olive extract rich in hydroxytyrosol). The second type is the essential oil of Commipora myrrha, a singlet oxygen quencher. These properties were confirmed using the 2,2‐diphenyl‐1‐picrylhydrazyl test for antiradical capacity [Yoshida et al. (1989) Chem. Pharm. Bull., 37, 1919; Buenger et al. (2006) Int. J. Cosmet. Sci., 28, 135] and 1,3‐diphenylisobenzofuran test for the capacity to quench singlet oxygen [Kochewar and Redmond (2000) Meth. Enzymol. , 28, 319; Racine and Auffray (2005) Fitoterapia, 76, 316]. Furthermore, we have extended an ex vivo method to classify the efficacy of cosmetics to protect squalene by collecting sebum in vivo and irradiating it in a controlled way. The squalene monohydroperoxide formation is monitored by high performance liquid chromatography. This methods allows us to compare the efficiency of the three antioxidants at 0.6% in a cosmetic formulation to protect squalene from photo oxidation. Our results clearly show that essential oil of Commiphora myrrha provides the best protection against squalene peroxidation. These results demonstrate that squalene peroxidation during solar exposure is mainly because of singlet oxygen and not due to free radical attack. This suggests that sun care cosmetics should make use not only of free radical scavengers but also of singlet oxygen quenchers.
Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains

T20 (generic name: Enfuvirtide, brand name: Fuzeon) is the only FDA-approved HIV fusion inhibitor that is being used for treatment of HIV/AIDS patients who have failed to respond to current antiretroviral drugs. However, it rapidly induces drug resistance in vitro and in vivo. On the basis of the structural and functional information of anti-HIV peptides from a previous study, we designed an HIV fusion inhibitor named CP32M, a 32-mer synthetic peptide that is highly effective in inhibiting infection by a wide range of primary HIV-1 isolates from multiple genotypes with R5- or dual-tropic (R5X4) phenotype, including a group O virus (BCF02) that is resistant to T20 and C34 (another anti-HIV peptide). Strikingly, CP32M is exceptionally potent (at low picomolar level) against infection by a panel of HIV-1 mutants highly resistant to T20 and C34. These findings suggest that CP32M can be further developed as an antiviral therapeutic against multidrug resistant HIV-1.
Evaluation of Vascular Function in Apolipoprotein E Knockout Mice With Angiotensin-Dependent Renovascular Hypertension

It is known that the endothelial function is compromised in atherosclerosis and arterial hypertension and that angiotensin is an important factor contributing to both pathophysiologies. The aim of this study was to evaluate the vascular function in a hypercholesterolemia/atherosclerosis model, in the angiotensin II–dependent 2-kidney 1-clip (2K1C) hypertension model and when both conditions coexist. Eight-week-old apolipoprotein E knockout (apoE; n=20) and C57BL/6 (C57; n=20) mice underwent a 2K1C or sham operation and were studied 28 days later. Mean arterial pressure was higher in apoE—2K1C and C57–2K1C (126±3 and 128±3 mm Hg) when compared with the apoE–Sham and C57–Sham (103±2 and 104±2 mm Hg, respectively; P<0.05). The vascular reactivity to norepinephrine (NE; 10−9 to 2×10−3 mol/L), acetylcholine (ACh), and sodium nitroprusside (SNP; 10−10 to 10−3 mol/L) was evaluated in the mesenteric arteriolar bed through concentration–effect curves. NE caused vascular hyper-reactivity in apoE–Sham, apoE–2K1C, and C57–2K1C (maximal response 146±5, 144±5, and 159±4 mm Hg, respectively) compared with C57–Sham (122±7 mm Hg; P<0.05). The ACh-induced relaxation was smaller (P<0.05) in apoE–2K1C and C57–2K1C (maximal response 53±3% and 46±3%) than in apoE–Sham and C57–Sham mice (78±5% and 73±4%). SNP-induced vascular relaxation showed similar concentration–effect curves in all groups. We conclude that in C57–2K1C mice, the increased reactivity to NE and the decreased endothelium-dependent relaxation contribute to the maintenance of hypertension. The apoE mouse, at early stages of atherosclerosis, shows hyper-reactivity to NE but does not have endothelium dysfunction yet. However, the concurrence of both pathophysiologies does not result in additive effects on the vascular function.
Filtered OFDM: A new waveform for future wireless systems

A spectrally-localized waveform is proposed based on filtered orthogonal frequency division multiplexing (f-OFDM). By allowing the filter length to exceed the cyclic prefix (CP) length of OFDM and designing the filter appropriately, the proposed f-OFDM waveform can achieve a desirable frequency localization for bandwidths as narrow as a few tens of subcarriers, while keeping the inter-symbol interference/inter-carrier interference (ISI/ICI) within an acceptable limit. Enabled by the proposed f-OFDM, an asynchronous filtered orthogonal frequency division multiple access (f-OFDMA)/filtered discrete-Fourier transform-spread OFDMA (f-DFT-S-OFDMA) scheme is introduced, which uses the spectrum shaping filter at each transmitter for side lobe leakage elimination and a bank of filters at the receiver for inter-user interference rejection. Per-user downsampling and short fast Fourier transform (FFT) are used at the receiver to ensure a reasonable complexity of implementation. The proposed scheme removes the inter-user time-synchronization overhead required in the synchronous OFDMA/DFT-S-OFDMA. The performance of the asynchronous f-OFDMA is evaluated and compared with that of the universal-filtered OFDM (UF-OFDM), proposed in [1], [2].
An Additive Branch-and-Bound Algorithm for the Pickup and Delivery Traveling Salesman Problem with LIFO or FIFO Loading

Abstract This paper introduces an additive branch-and-bound algorithm for two variants of the pickup and delivery traveling salesman problem in which loading and unloading operations have to be performed either in a Last-In-First-Out (LIFO) or in a First-In-First-Out (FIFO) order. Two relaxations are used within the additive approach: the assignment problem and the shortest spanning r-arborescence problem. The quality of the lower bounds is further improved by a set of elimination rules applied at each node of the search tree to remove from the problem arcs that cannot belong to feasible solutions because of precedence relationships. The performance of the algorithm and the effectiveness of the elimination rules are assessed on instances from the literature.
Robustness of scale-free networks to cascading failures induced by fluctuating loads

Taking into account the fact that overload failures in real-world functional networks are usually caused by extreme values of temporally fluctuating loads that exceed the allowable range, we study the robustness of scale-free networks against cascading overload failures induced by fluctuating loads. In our model, loads are described by random walkers moving on a network and a node fails when the number of walkers on the node is beyond the node capacity. Our results obtained by using the generating function method show that scale-free networks are more robust against cascading overload failures than Erdős-Rényi random graphs with homogeneous degree distributions. This conclusion is contrary to that predicted by previous works, which neglect the effect of fluctuations of loads.
Health Effects of Media on Children and Adolescents

Youth spend an average of >7 hours/day using media, and the vast majority of them have access to a bedroom television, computer, the Internet, a video-game console, and a cell phone. In this article we review the most recent research on the effects of media on the health and well-being of children and adolescents. Studies have shown that media can provide information about safe health practices and can foster social connectedness. However, recent evidence raises concerns about media's effects on aggression, sexual behavior, substance use, disordered eating, and academic difficulties. We provide recommendations for parents, practitioners, the media, and policy makers, among others, for ways to increase the benefits and reduce the harm that media can have for the developing child and for adolescents.
Critical video quality for distributed automated video surveillance

Large-scale distributed video surveillance systems pose new scalability challenges. Due to the large number of video sources in such systems, the amount of bandwidth required to transmit video streams for monitoring often strains the capability of the network. On the other hand, large-scale surveillance systems often rely on computer vision algorithms to automate surveillance tasks. We observe that these surveillance tasks present an opportunity for trade-off between the accuracy of the tasks and the bit rate of the video being sent. This paper shows that there exists a sweet spot, which we term critical video quality that can be used to reduce video bit rate without significantly affecting the accuracy of the surveillance tasks. We demonstrate this point by running extensive experiments on standard face detection and face tracking algorithms. Our experiments show that face detection works equally well even if the quality of compression is significantly reduced, and face tracking still works even if the frame rate is reduced to 6 frames per second. We further develop a prototype video surveillance system to demonstrate this idea. Our evaluation shows that we can achieve up to 29 times reduction in video bit rate when detecting faces and 16 times reduction when tracking faces. This paper also proposes a formal rate-accuracy optimization framework which can be used to determine appropriate encoding parameters in distributed video surveillance systems that are subjected to either bandwidth constraints or accuracy constraints.
Molecular epidemiology of impetiginous group A streptococcal infections in aboriginal communities of northern Australia

Group A streptococcal infections among the Aboriginal communities of the Northern Territory of Australia are endemic, with a concurrently high rate of the postinfection sequelae of rheumatic fever and acute post-streptococcal glomerulonephritis. The majority of the group A streptococcal isolates from the Northern Territory are not typeable by M typing. We recently developed a novel genotyping method, Vir typing. A preliminary study using this method discriminated all the M-nontypeable (MNT) isolates. Vir typing is based on restriction fragment length polymorphisms of the 4- to 7-kb Vir regulon of group A streptococci, which contains a number of genes, including emm (the gene for M protein). A total of 407 isolates of group A streptococci obtained from four Aboriginal communities over a 4-year period were typed by this genotyping method. Forty-two distinct genotypes were found among the isolates, including 22 among the MNT isolates. The correlation between Vir type and M type was good. This genotyping method allows the characterization of all group A streptococcal isolates from Aboriginal communities in the Northern Territory. We also propose that Vir typing be used in conjunction with M typing for epidemiological surveillance in geographical regions where the majority of isolates are MNT.
Leptospirosis: epidemiology and preventive measures

Leptospirosis is probably the world’s most widespread zoonosis of global importance. It occurs in both developed and developing countries and large outbreaks have been reported from all over the world. Leptospirosis is now being recognized as a re-emerging infectious disease. Understanding the epidemiology of this infectious disease is a critical step for designing interventions and consequently diminishing the risk of leptospirosis transmission. This article reviews on the epidemiological features of leptospirosis. Moreover, depending on these epidemiological data preventive measures are being suggested.
Idiopathic polypoidal choroidal vasculopathy in Thai patients with clinical and angiographic choroidal neovascularization

Objective This study aimed to study the prevalence and characteristics of idiopathic polypoidal choroidal vasculopathy (IPCV) in Thai patients with clinical and angiographic choroidal neovascularization (CNV). Patients and methods A consecutive case study of 140 patients presenting with CNV was conducted in nine large referral eye centers throughout Thailand. The demographic data, fundus photographs, fundus fluorescein angiography and indocyanine green angiography of the patients were analyzed. Results Of 129 patients with clinical and angiographic CNV, IPCV was diagnosed in 100 patients (77.52%), idiopathic CNVs in 16 patients (12.40%) and age-related macular degeneration (AMD) in 12 patients (9.30%). Of the 107 eyes with IPCV, 90 eyes (84.11%) had both branching venous networks (BVNs) and polypoidal lesions. Most IPCV patients (93%) had unilateral involvement and were at a younger age than AMD patients. In all, 79 eyes (73.83%) had lesions found in the macular area, 14 eyes (13.08%) in the temporal to vascular arcades, ten eyes (9.35%) in the peripapillary area and four eyes (3.74%) in both macular and peripapillary areas. The clinical manifestations of IPCV at presentation were categorized into two patterns. There were 95 eyes (88.79%) of a hemorrhagic pattern and 12 eyes (11.21%) of an exudative pattern. Conclusion IPCV is the most common macular disease in Thai patients with CNV. Most IPCVs have both BVNs and polypoidal lesions located in the macular area and present with a hemorrhagic pattern.
Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases

Glycosphingoid bases are elevated in inherited lysosomal storage disorders with deficient activity of glycosphingolipid catabolizing glycosidases. We investigated the molecular basis of the formation of glucosylsphingosine and globotriaosylsphingosine during deficiency of glucocerebrosidase (Gaucher disease) and α‐galactosidase A (Fabry disease). Independent genetic and pharmacological evidence is presented pointing to an active role of acid ceramidase in both processes through deacylation of lysosomal glycosphingolipids. The potential pathophysiological relevance of elevated glycosphingoid bases generated through this alternative metabolism in patients suffering from lysosomal glycosidase defects is discussed.
A secure routing protocol for ad hoc networks

Most recent ad hoc network research has focused on providing routing services without considering security. We detail security threats against ad hoc routing protocols, specifically examining AODV and DSR. In light of these threats, we identify three different environments with distinct security requirements. We propose a solution to one, the managed-open scenario where no network infrastructure is pre-deployed, but a small amount of prior security coordination is expected. Our protocol, authenticated routing for ad hoc networks (ARAN), is based on certificates and successfully defeats all identified attacks.
Reproducibility of global three-dimensional motion during manual atlanto-axial rotation mobilization: an in vitro study

Abstract The reproducibility of the three-dimensional (3D) kinematic aspects of motion coupling patterns during manual mobilizing techniques is still a debatable matter. The present in vitro study analysed segmental 3D motion of the atlanto-axial joint during manual axial rotation mobilization. Twenty fresh frozen human cervical specimens were studied in a test–retest situation with two examiners. The specimens were manually mobilized using three different techniques: (1) a regional mobilization technique of the cervical spine; (2) a segmental mobilization technique of the atlas with manual fixation of the axis; and (3) a segmental mobilization of the atlas on the axis applying a locking technique. Segmental atlanto-axial kinematics was registered with a Zebris CMS-20 ultrasound-based tracking system. The Euclidian norm was used as a representation of overall 3D motion. The results indicated good reproducibility (mean intraclass correlation coefficient, ICC: 0.87). Intraobserver reproducibility was slightly higher (mean ICC: 0.91; range: 0.76–0.99) than interobserver reproducibility (mean ICC: 0.85; range: 0.56–0.98) (P < 0.05). The total range of motion expressed as the Euclidean norm of 3D motion components was a parameter with good reproducibility in the study of segmental kinematics of manual atlanto-axial mobilization. Although previous studies have demonstrated poor inter-rater reliability of manual examination and mobilization of segmental motion components, the results of the present study shed a new and more positive light on the reproducibility of techniques for manual mobilization of the upper cervical spine.
Selective Processing of Vestibular Reafference during Self-Generated Head Motion

The vestibular sensory apparatus and associated vestibular nuclei are generally thought to encode head-in-space motion. Angular head-in-space velocity is detected by vestibular hair cells that are located within the semicircular canals of the inner ear. In turn, the afferent fibers of the vestibular nerve project to neurons in the vestibular nuclei, which, in head-restrained animals, similarly encode head-in-space velocity during passive whole-body rotation. However, during the active head-on-body movements made to generate orienting gaze shifts, neurons in the vestibular nuclei do not reliably encode head-in-space motion. The mechanism that underlies this differential processing of vestibular information is not known. To address this issue, we studied vestibular nuclei neural responses during passive head rotations and during a variety of tasks in which alert rhesus monkeys voluntarily moved their heads relative to space. Neurons similarly encoded head-in-space velocity during passive rotations of the head relative to the body and during passive rotations of the head and body together in space. During all movements that were generated by activation of the neck musculature (voluntary head-on-body movements), neurons were poorly modulated. In contrast, during a task in which each monkey actively “drove” its head and body together in space by rotating a steering wheel with its arm, neurons reliably encoded head-in-space motion. Our results suggest that, during active head-on-body motion, an efferent copy of the neck motor command, rather than the monkey's knowledge of its self-generated head-in-space motion or neck proprioceptive information, gates the differential processing of vestibular information at the level of the vestibular nuclei.
Intranasal and intramuscular proteosome-staphylococcal enterotoxin B (SEB) toxoid vaccines: immunogenicity and efficacy against lethal SEB intoxication in mice

Intranasal or intramuscular (i.m.) immunization of mice and i.m. immunization of rabbits with formalinized staphylococcal enterotoxin B (SEB) toxoid in saline elicited higher anti-SEB serum immunoglobulin G (IgG) titers when the toxoid was formulated with proteosomes. In addition, intranasal immunization of mice with this proteosome-toxoid vaccine elicited high levels of anti-SEB IgA in lung and intestinal secretions, whereas the toxoid without proteosomes did not. Two i.m. immunizations with proteosome-toxoid plus alum also induced higher murine serum responses than alum-adjuvanted toxoid without proteosomes. Furthermore, proteosome-toxoid delivered intranasally in saline or i.m. with either saline or alum afforded significant protection against lethal SEB challenge in two D-galactosamine-sensitized murine models of SEB intoxication, i.e., the previously described i.m. challenge model and a new respiratory challenge model of mucosal SEB exposure. Efficacy correlated with the induction of high serum levels of anti-SEB IgG. In contrast, intranasal or i.m. immunization with toxoid in saline without proteosomes was not significantly protective in either challenge model. Proteosome-toxoid plus alum given i.m. also elicited more significant protection against respiratory challenge than the alum-adjuvanted toxoid alone. The capacity of proteosomes to enhance both i.m. and intranasal immunogenicity and efficacy of SEB toxoid indicates that testing such proteosome-SEB toxoid vaccines in the nonhuman primate aerosol challenge model of SEB intoxication prior to immunogenicity trials in humans is warranted. These data expand the applicability of the proteosome mucosal vaccine delivery system to protein toxoids and suggest that respiratory delivery of proteosome vaccines may be practical for enhancement of both mucosal and systemic immunity against toxic or infectious diseases.
Satisfying Degree D Equations over Gf [2]

We study the problem where we are given a system of polynomial equations defined by multivariate polynomials over GF [2] of fixed constant degree d > 1 and the aim is to satisfy the maximal number of equations. A random assignment approximates this problem within a factor 2−d and we prove that for any > 0, it is NP-hard to obtain a ratio 2−d + . When considering instances that are perfectly satisfiable we give a probabilistic polynomial time algorithm that, with high probability, satisfies a fraction 21−d − 21−2d and we prove that it is NP-hard to do better by an arbitrarily small constant. The hardness results are proved in the form of inapproximability results of Max-CSPs where the predicate in question has the desired form and we give some immediate results on approximation resistance of some predicates.