Miracle-dz/UniFAR-FTUs huggingface dataset:
Housing characteristics and indoor air quality in households of Alaska Native children with chronic lung conditions

Alaska Native children experience high rates of respiratory infections and conditions. Household crowding, indoor smoke, lack of piped water, and poverty have been associated with respiratory infections. We describe the baseline household characteristics of children with severe or chronic lung disease participating in a 2012-2015 indoor air study. We monitored indoor PM2.5, CO2 , relative humidity %, temperature, and VOCs and interviewed caregivers about children's respiratory symptoms. We evaluated the association between reported children's respiratory symptoms and indoor air quality indicators using multiple logistic regression analysis. Compared with general US households, study households were more likely overcrowded 73% (62%-82%) vs 3.2% (3.1%-3.3%); had higher woodstove use as primary heat source 16% (9%-25%) vs 2.1% (2.0%-2.2%); and higher proportion of children in a household with a smoker 49% (38%-60%) vs 26.2% (25.5%-26.8%). Median PM2.5 was 33 μg/m3 . Median CO2 was 1401 ppm. VOCs were detectable in all homes. VOCs, smoker, primary wood heat, and PM2.5>25 μg/m3 were associated with higher risk for cough between colds; VOCs were associated with higher risk for wheeze between colds and asthma diagnosis. High indoor air pollutant levels were associated with respiratory symptoms in household children, likely related to overcrowding, poor ventilation, woodstove use, and tobacco smoke.
Psychometric properties of the St George's Respiratory Questionnaire in patients with idiopathic pulmonary fibrosis

The St George's Respiratory Questionnaire (SGRQ) has been used to measure health-related quality of life (HRQoL) in patients with idiopathic pulmonary fibrosis (IPF). This analysis evaluated the psychometric properties of the SGRQ using data from 428 patients with IPF who participated in a 12-month, randomised, placebo-controlled phase II trial of nintedanib. Internal consistency (Cronbach's α) was 0.91 for SGRQ total and >0.70 for domain scores. Test–retest reliability (intraclass correlation coefficients) was 0.77, 0.77, 0.69 and 0.66 for SGRQ total, activity, impact and symptoms scores, respectively. Construct validity of SGRQ total and domain scores was supported by weak to moderate cross-sectional correlations with the Medical Research Council dyspnoea scale (0.32–0.55), 6-min walk test distance (−0.25– −0.34), percentage predicted forced vital capacity (−0.11– −0.15) and measures of gas exchange (−0.26–0.03). There was some evidence that the SGRQ total score was sensitive to detecting change. The reliability, construct validity and responsiveness of the SGRQ in patients with IPF suggest that this is an acceptable measure of HRQoL in patients with IPF. The SGRQ is an acceptable measure of aspects of health-related quality of life in patients with IPF http://ow.ly/jMjf305bjZ5
Regulatory T cells in renal disease

The kidney is vulnerable to injury, both acute and chronic from a variety of immune and metabolic insults, all of which at least to some degree involve inflammation. Regulatory T cells modulate systemic autoimmune and allogenic responses in glomerulonephritis and transplantation. Intrarenal regulatory T cells (Tregs), including those recruited to the kidney, have suppressive effects on both adaptive and innate immune cells, and probably also intrinsic kidney cells. Evidence from autoimmune glomerulonephritis implicates antigen‐specific Tregs in HLA‐mediated dominant protection, while in several human renal diseases Tregs are abnormal in number or phenotype. Experimentally, Tregs can protect the kidney from injury in a variety of renal diseases. Mechanisms of Treg recruitment to the kidney include via the chemokine receptors CCR6 and CXCR3 and potentially, at least in innate injury TLR9. The effects of Tregs may be context dependent, with evidence for roles for immunoregulatory roles both for endogenous Tbet‐expressing Tregs and STAT‐3‐expressing Tregs in experimental glomerulonephritis. Most experimental work and some of the ongoing human trials in renal transplantation have focussed on unfractionated thymically derived Tregs (tTregs). However, induced Tregs (iTregs), type 1 regulatory T (Tr1) cells and in particular antigen‐specific Tregs also have therapeutic potential not only in renal transplantation, but also in other kidney diseases.
The Role of Emotional Intelligence in Anxiety and Depression among Adolescents

This Study examined the relationship between emotional intelligence, anxiety and depression among adolescents. Two hundred and fifty high-school students were administered the Trait Meta-Mood Scale (TMMS), a self-report measure of emotional intelligence, along with measures of thought suppression, self-esteem, anxiety, and depression. It was hypothesized that emotional abilities would predict psychological adjustment above and beyond factors that have been previously associated with poor adjustment (i.e., self- esteem and thought suppression). The study revealed two main findings. First, self-reported ability to regulate mood (Emotional Repair) was positively related to self-esteem. Second, self-reported emotional intelligence was negatively related to levels of depression and anxiety. Specifically, the ability to discriminate clearly among feelings (Emotional Clarity) and the ability to self- regulate emotional states were associated with better psychological adjustment, independent of the effects of self-esteem and thought suppression. The results provide support for the hypothesis that emotional abilities are an important and unique contributor to psychological adjustment.
Energy Efficient Scheduling for mmWave Backhauling of Small Cells in Heterogeneous Cellular Networks

Heterogeneous cellular networks with small cells densely deployed underlying the conventional homogeneous macrocells are emerging as a promising candidate for the fifth generation (5G) mobile network. When a large number of base stations are deployed, the cost-effective, flexible, and green backhaul solution becomes one of the most urgent and critical challenges. With vast amounts of spectrum available, wireless backhaul in the millimeter wave (mmWave) band is able to provide several-Gbps transmission rates. To overcome high propagation loss at higher frequencies, mmWave backhaul utilize beamforming to achieve directional transmission, and concurrent transmissions (spatial reuse) under low inter-link interference can be enabled to significantly improve network capacity. To achieve an energy efficient solution for the mmWave backhauling of small cells, we first formulate the problem of minimizing the energy consumption via concurrent transmission scheduling and power control into a mixed integer nonlinear programming problem. Then we develop an energy efficient and practical mmWave backhauling scheme, where the maximum independent set based scheduling algorithm and the power control algorithm are proposed to exploit the spatial reuse for low energy consumption and high energy efficiency. We also theoretically analyze the conditions that our scheme reduces energy consumption, and the choice of the interference threshold for energy reduction. Through extensive simulations under various traffic patterns and system parameters, we demonstrate the superior performance of our scheme in terms of energy consumption and energy efficiency, and also analyze the choice of the interference threshold under different traffic loads, BS distributions, and the maximum transmission power.
Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions

BACKGROUND Schizophrenia is associated with increased physical morbidity and early mortality, suggesting that the aging process may be accelerated in schizophrenia. However, the biological underpinnings of these alterations in aging in schizophrenia are unclear. METHOD We conducted a detailed search of peer-reviewed empirical studies to evaluate evidence for accelerated biological aging in schizophrenia based on systemic, age-related biomarkers. We included studies that investigated differences between persons with schizophrenia and healthy comparison subjects in levels of biomarkers known to be associated with aging and examined the relationship of these biomarkers to age in the 2 groups. RESULTS Forty-two articles that met our selection criteria were reviewed. Nearly 75% reported abnormal biomarker levels among individuals with schizophrenia, including indices of inflammation, cytotoxicity, oxidative stress, metabolic health, gene expression, and receptor/synaptic function, with medium to large effect sizes reported in many studies. Twenty-nine percent of the studies observed differential age-related decline in schizophrenia. Markers of receptor/synaptic function and gene expression were most frequently differentially related to age in schizophrenia. Schizophrenia patients with greater disease severity and longer illness duration exhibited higher levels of inflammatory and oxidative stress biomarkers and shorter telomere length. CONCLUSIONS Most studies show biomarker abnormalities in schizophrenia, and there is some suggestion for accelerated aging. Although definitive interpretation is limited by cross-sectional design of the published reports, findings in the area of gene expression and synaptic function are promising and pave the way for future longitudinal studies needed to fully test this hypothesis.
Fate of abstracts presented at a National Turkish Orthopedics and Traumatology Congress: publication rates and consistency of abstracts compared with their subsequent full-text publications.

OBJECTIVE The aim of this study was to evaluate the publication rates of full-text articles after presentation of abstracts at a Turkish National Orthopaedics and Traumatology Congress, determine the time lag from the congress date to publication of full-text articles and assess the consistency between abstracts and the subsequent publications. METHODS All abstracts from the scientific program of the 20th Turkish National Orthopaedics and Traumatology Congress (2007) were identified and computerized PubMed searches were conducted to determine whether an abstract had been followed by publication of a full-text article and key features were compared to evaluate their consistency. The time lag to publication and the impact factors of the journals where the articles were published were noted. RESULTS Of the 770 abstracts (264 oral, 506 poster presentations), 227 (29.5%) were followed by a full-text and 116 (44%) of the 264 oral and 111 (22%) of the 506 poster presentations were published. The mean time to publication was 14.9±16.075 (range: 33 to 55) months. Thirty-three (14.5%) were published prior to the presentation at the congress. The likelihood of publication decreased after the third year (26 of 227, 11.5%). A total of 182 (80.2%) articles showed inconsistencies with the abstract; 74 (32.6%) minor, 14 (6.2%) major, and 94 (41.4%) minor and major inconsistencies. The mean impact factor of the journals was 1.152±0.858. CONCLUSION The vast majority of abstracts presented at this congress were not followed by publication of a full-text article. Additionally, frequent inconsistencies between the final published article and the original abstract indicated the inadequacy of quality of reporting in abstracts.
Bringing Time Back In: A Study on the Influence of Travel Time Variations and Facility Opening Hours on Individual Accessibility

Although recent studies of individual accessibility have used detailed representations of urban street networks, unrealistic measures of travel time based on assumptions about constant travel speeds through the network were often used. Utilizing constant travel times does not allow for daily congestion and assumes that the effects of congestion are uniform throughout the city and affect all people equally. This research measures individual space-time accessibility in order to show that the incorporation of locally specific travel times within a street network allows a significant increase in the ability to realistically evaluate individual accessibility within cities. The results show that the accessibility of individuals within cities is not homogenous, and neither does access to employment or shopping opportunities vary according to common expectations about urban form and human behavior. Instead, the role of distance in predicting accessibility variations within cities is quite limited. This article also shows that incorporating time into accessibility measures in the form of congestion and business hours leads to additional (and highly spatially uneven) reductions in accessibility, revealing that the temporal dimension is very important to accurately assessing individual accessibility.
Improved reliability-based decision support methodology applicable in system-level failure diagnosis and prognosis

Reliability modeling and troubleshooting reasoning involving complex component interactions in complex systems are an active research topic and a critical challenge to be overcome in decision support. In this paper, we propose an innovative concept of decision support methodology for system failure diagnosis and prognosis in complex systems. Advanced causal structure, incorporating domain and engineering knowledge, and a new Bayesian network (BN) representation of system structure and component interaction are proposed. Based on the BN representation, a Bayesian framework is developed to analyze and fuse the multisource information from different hierarchical levels of a system. This capability supports higher-fidelity modeling and assessing of the reliability of the components, the subsystems, and the system as a whole. The feasibility of our advanced causal structure approach has been proven with implementation using test data acquired from electromechanical actuator systems. A case study is successfully conducted to demonstrate the effectiveness of the proposed methodology. The proposed decision support process in integrated system health management will enable enhancements in flight safety and condition-based maintenance by increasing availability and mission effectiveness while reducing maintenance costs.
Lung ultrasound immediately after birth to describe normal neonatal transition: an observational study

Objective Lung ultrasound (LUS) has shown promise as a diagnostic tool for the evaluation of the newborn with respiratory distress. No study has described LUS during ‘normal’ transition. Our goal was to characterise the appearance of serial LUS in healthy newborns from the first minutes after birth until airway liquid clearance is achieved. Study design Prospective observational study. Setting Single-centre tertiary perinatal centre in Australia. Patients Of 115 infants born at ≥35 weeks gestational age, mean (SD) gestational age of 386/7 weeks±11 days, mean birth weight of 3380±555 g, 51 were delivered vaginally, 14 via caesarean section (CS) after labour and 50 infants via elective CS. Interventions We obtained serial LUS videos via the right and left axillae at 1–10 min, 11–20 min and 1, 2, 4 and 24 hours after birth. Main outcome measures LUS videos were graded for aeration and liquid clearance according to a previously validated system. Results We analysed 1168 LUS video recordings. As assessed by LUS, lung aeration and airway liquid clearance occurred quickly. All infants had an established pleural line at the first examination (median=2 (1–4) min). Only 14% of infants had substantial liquid retention at 10 min after birth. 49%, 78% and 100% of infants had completed airway liquid clearance at 2, 4 and 24 hours, respectively. Conclusions In healthy transitioning newborn infants, lung aeration and partial liquid clearance are achieved on the first minutes after birth with complete liquid clearance typically achieved within the first 4 hours of birth. Trial registration number ANZCT 12615000380594.
International Journal of Women's Health Dovepress Twin versus Singleton Pregnancies: the Incidence, Pregnancy Complications, and Obstetric Outcomes in a Nigerian Tertiary Hospital

Background: Twin pregnancy is associated with more pregnancy complications and poorer pregnancy outcome than singleton pregnancy. Hence periodic review is necessary to improve on the pregnancy outcome. Objective: To determine the incidence and compare pregnancy complications and obstetric outcomes of twin pregnancies and singleton pregnancies. Materials and methods: The twin pregnancies (study group) that were delivered at Nnamdi were compared with singleton deliveries (control group) that occurred in the same hospital during the same period. Results: A total of 3351 deliveries were conducted during the study period, of which 113 were twin deliveries, giving an incidence of 1:29.6 deliveries. Only 100 case files could be retrieved for analysis. The mean parities for the twins and singletons were 2.7 ± 2.33 weeks and 1.96 ± 1.87 weeks whereas the mean gestational age at delivery for twin and singleton deliveries were 34 ± 5.2 weeks and 38.7 ± 2.4 weeks respectively (P , 0.05). The mean birth weights were 3.14 ± 0.73 kg and 2.3 ± 1.0 kg for singletons and twins respectively (P , 0.05). Hypertensive disorders of pregnancy, cord prolapse, malpresentation, premature rupture of membranes, low Apgar scores, cesarean section rate, and perinatal death were significantly higher in twin pregnancies than in singleton. Conclusion: The incidence of twin pregnancy over the study period was high and was significantly associated with more pregnancy complications and poorer obstetric outcomes. Close antenatal and intrapartum care are needed in order to improve outcome and decrease complications.
MTHFR A1298C and C677T Polymorphisms Are Associated with Increased Risk of Venous Thromboembolism: A Retrospective Chart Review Study

Background: Methylene tetrahydrofolate reductase (MTHFR) is a key enzyme in homocysteine metabolism. This study aims to determine the impact of MTHFR polymorphisms on plasma homocysteine levels and risks of venous thromboembolism (VTE). Methods: This retrospective chart review study included a total of 188 subjects who were tested for MTHFR polymorphisms at Metrowest Coagulation Laboratory between April 2011 and April 2016. Two independent coders were trained to extract relevant clinical data for statistical analysis. Results: VTE occurred in 50% of patients with compound mutation, compared with only 28.6% of subjects from the wild-type group. Patients with heterozygous or homozygous A1298C or C677T variants had an intermediate risk of VTE. The median homocysteine level in the wild-type group was slightly lower than that of heterozygous or homozygous MTHFR variants. The difference, however, was not significant (p = 0.6193). Moreover, there was no difference in plasma homocysteine level between patients with VTE versus VTE-free (p = 0.4923). Conclusions: Heterozygous or homozygous MTHFR variants, especially a compound mutation, are associated with increased risk of VTE. Hyperhomocysteinemia does not correlate with MTHFR polymorphisms or VTE risk. Hence, MTHFR genotyping provides more consistent assessment of VTE risk. This information can be incorporated into risk stratification for early intervention and prophylaxis of VTE.
Author's Personal Copy Probabilistic Reversal Learning Is Impaired in Parkinson's Disease

—In many everyday settings, the relationship between our choices and their potentially rewarding outcomes is probabilistic and dynamic. In addition, the difficulty of the choices can vary widely. Although a large body of theoretical and empirical evidence suggests that dopamine mediates rewarded learning, the influence of dopamine in probabilistic and dynamic rewarded learning remains unclear. We adapted a probabilistic rewarded learning task originally used to study firing rates of dopamine cells in primate substantia nigra pars compacta [ (2006) Midbrain dopamine neurons encode decisions for future action. Nat Neurosci 9:1057–1063] for use as a reversal learning task with humans. We sought to investigate how the dopamine depletion in Parkinson's disease (PD) affects probabilistic reward learning and adaptation to a reversal in reward contingencies. Over the course of 256 trials subjects learned to choose the more favorable from among pairs of images with small or large differences in reward probabilities. During a subsequent otherwise identical reversal phase, the reward probability contingencies for the stimuli were reversed. Seventeen PD patients of mild to moderate severity were studied off of their dopaminergic medications and compared to 15 age-matched controls. Compared to controls , PD patients had distinct pre-and post-reversal deficiencies depending upon the difficulty of the choices they had to learn. The patients also exhibited compromised adaptability to the reversal. A computational model of the subjects' trial-by-trial choices demonstrated that the adaptability was sensitive to the gain with which patients weighted pre-reversal feedback. Collectively, the results implicate the nigral dopa-minergic system in learning to make choices in environments with probabilistic and dynamic reward contingencies. It has become clear in recent years that Parkinson's disease (PD) affects not only the initiation and control of movements, but also motivational drive and reward-seeking behavior (Borek et al., 2006), which themselves are fundamental to the learning of new responses. A classic neuropathology of PD is the degeneration of dopamine cells in the substantia nigra pars compacta (Dauer and Przedborski, 2003). This not only produces a substantially reduced tonic level of dopaminergic activity in efferent targets, but also likely impairs phasic dopaminergic activity A broad body of theoretical and empirical evidence has accumulated suggesting that phasic activity of the midbrain dopa-mine system is critical to trial by trial feedback-based learning (Abler et al., 2006). The predominant concept is that the phasic dopamine activity signals actual versus expected reward values, or a reward " prediction error " (Mon-tague et …
Solitary Fibrous Tumor of the Greater Omentum, Mimicking Gastrointestinal Stromal Tumor of the Small Intestine: A Case Report

Solitary fibrous tumor (SFT) is one of the mesenchymal tumors, which rarely arises in the abdominal space. We report a very rare case of abdominal SFT, mimicking another mesenchymal tumor. A 52-year-old Japanese man was referred to our hospital for further evaluation and treatment of gallbladder polyp. Contrast-enhanced computed tomography (CT) showed an enhanced nodule within the gallbladder, and incidentally, also showed a well-circumscribed mass adjacent to the small intestine. The mass was depicted as slightly high density in plain CT, and with contrast-enhancement, the mass was partially stained in early phase and the stained area spread heterogeneously in delayed phase. Magnetic resonance imaging showed that the abdominal mass was depicted as slightly high intensity on T2-weighted imaging and low intensity on T1-weighted imaging. With double-balloon endoscopy and capsule endoscopy, we did not find any tumor inside the small intestine. These visual findings lead us to diagnose it as gastrointestinal stromal tumor of the small intestine with extraluminal growth. We planned to resect both the gallbladder polyp and the intraperitoneal tumor at the same time for pathologic diagnosis and treatment. When the operation was performed, we found a milk-white lobulated tumor on the greater omentum and the tumor was entirely resected. Microscopically, the gallbladder polyp was diagnosed as tubular adenoma, and the omental tumor was diagnosed as SFT. It is important to bear in mind that omental SFTs sometimes mimic other mesenchymal tumors and should be included in the differential diagnosis of abdominal tumor not revealed by endoscopy.