Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting Protein Functions by Using Unbalanced Random Walk Algorithm on Three Biological Networks

With the gap between the sequence data and their functional annotations becomes increasing wider, many computational methods have been proposed to annotate functions for unknown proteins. However, designing effective methods to make good use of various biological resources is still a big challenge for researchers due to function diversity of proteins. In this work, we propose a new method named ThrRW, which takes several steps of random walking on three different biological networks: protein interaction network (PIN), domain co-occurrence network (DCN), and functional interrelationship network (FIN), respectively, so as to infer functional information from neighbors in the corresponding networks. With respect to the topological and structural differences of the three networks, the number of walking steps in the three networks will be different. In the course of working, the functional information will be transferred from one network to another according to the associations between the nodes in different networks. The results of experiment on S. cerevisiae data show that our method achieves better prediction performance not only than the methods that consider both PIN data and GO term similarities, but also than the methods using both PIN data and protein domain information, which verifies the effectiveness of our method on integrating multiple biological data sources.
Extending the Impact of Digital Games by Supporting Analogical Reasoning

The potential of digital games to support learning has been well documented, and yet the empirical evidence on the impacts of digital games on student learning finds varied effects. This paper explores an issue that we believe is central to realizing the potential of digital games for influencing learning: the relationship between games and the transfer of knowledge, and specifically the need to support the meaningful integration of games into instruction. We examine the theoretical and empirical literature on how middle-grade students can transfer knowledge and skills gained from digital gameplay to develop new conceptual models of the science concepts that the games target, focusing on the research on the use of analogical reasoning in science. Finally, we illustrate this approach with an example of using analogies with digital games in middle school science classes.
The MIQ-RS: A Suitable Option for Examining Movement Imagery Ability

Within rehabilitation settings, mental imagery helps to promote long-term recovery and facilitates compliance to rehabilitation exercises. Individuals who are able to effectively engage in imagery practice are likely to gain the most benefit from imagery training. Thus, a suitable imagery ability measurement tool for individuals with movement limitations is needed. The purpose of the present study was to evaluate the Movement Imagery Questionnaire—Revised second version (MIQ-RS), and compare the results of this new version with Hall and Martin's (1997) MIQ-R. Three-hundred and twenty participants from a variety of sports and performance levels agreed to take part. Results showed the internal consistency and test–retest reliability of the MIQ-RS were satisfactory, the two-factor structure of the MIQ-RS was supported by confirmatory factor analysis, and Pearson correlations indicated a strong relationship between the MIQ-R and MIQ-RS. It appears the MIQ-RS is a suitable option for examining movement imagery ability primarily aimed at the upper extremity.
Kernel Multi-task Learning using Task-specific Features

In this paper we are concerned with multitask learning when task-specific features are available. We describe two ways of achieving this using Gaussian process predictors: in the first method, the data from all tasks is combined into one dataset, making use of the task-specific features. In the second method we train specific predictors for each reference task, and then combine their predictions using a gating network. We demonstrate these methods on a compiler performance prediction problem, where a task is defined as predicting the speed-up obtained when applying a sequence of code transformations to a given program.
Tuberculosis Recurrence and Mortality after Successful Treatment: Impact of Drug Resistance

Background The DOTS (directly observed treatment short-course) strategy for tuberculosis (TB) control is recommended by the World Health Organization globally. However, there are few studies of long-term TB treatment outcomes from DOTS programs in high-burden settings and particularly settings of high drug resistance. A DOTS program was implemented progressively in Karakalpakstan, Uzbekistan starting in 1998. The total case notification rate in 2003 was 462/100,000, and a drug resistance survey found multidrug-resistant (MDR) Mycobacterium tuberculosis strains among 13% of new and 40% of previously treated patients. A retrospective, observational study was conducted to assess the capacity of standardized short-course chemotherapy to effectively cure patients with TB in this setting. Methods and Findings Using routine data sources, 213 patients who were sputum smear-positive for TB, included in the drug resistance survey and diagnosed consecutively in 2001–2002 from four districts, were followed up to a median of 22 months from diagnosis, to determine mortality and subsequent TB rediagnosis. Valid follow-up data were obtained for 197 (92%) of these patients. Mortality was high, with an average of 15% (95% confidence interval, 11% to 19%) dying per year after diagnosis (6% of 73 pansusceptible cases and 43% of 55 MDR TB cases also died per year). While 73 (74%) of the 99 new cases were “successfully” treated, 25 (34%) of these patients were subsequently rediagnosed with recurrent TB (13 were smear-positive on rediagnosis). Recurrence ranged from ten (23%) of 43 new, pansusceptible cases to six (60%) of ten previously treated MDR TB cases. MDR M. tuberculosis infection and previous TB treatment predicted unsuccessful DOTS treatment, while initial drug resistance contributed substantially to both mortality and disease recurrence after successful DOTS treatment. Conclusions These results suggest that specific treatment of drug-resistant TB is needed in similar settings of high drug resistance. High disease recurrence after successful treatment, even for drug-susceptible cases, suggests that at least in this setting, end-of-treatment outcomes may not reflect the longer-term status of patients, with consequent negative impacts for patients and for TB control.
Object Substitution Masking in Schizophrenia: An Event-Related Potential Analysis

Schizophrenia patients exhibit deficits on visual processing tasks, including visual backward masking, and these impairments are related to deficits in higher-level processes. In the current study we used electroencephalography techniques to examine successive stages and pathways of visual processing in a specialized masking paradigm, four-dot masking, which involves masking by object substitution. Seventy-six schizophrenia patients and 66 healthy controls had event-related potentials (ERPs) recorded during four-dot masking. Target visibility was manipulated by changing stimulus onset asynchrony (SOA) between the target and mask, such that performance decreased with increasing SOA. Three SOAs were used: 0, 50, and 100 ms. The P100 and N100 perceptual ERPs were examined. Additionally, the visual awareness negativity (VAN) to correct vs. incorrect responses, an index of reentrant processing, was examined for SOAs 50 and 100 ms. Results showed that patients performed worse than controls on the behavioral task across all SOAs. The ERP results revealed that patients had significantly smaller P100 and N100 amplitudes, though there was no effect of SOA on either component in either group. In healthy controls, but not patients, N100 amplitude correlated significantly with behavioral performance at SOAs where masking occurred, such that higher accuracy correlated with a larger N100. Healthy controls, but not patients, exhibited a larger VAN to correct vs. incorrect responses. The results indicate that the N100 appears to be related to attentional effort in the task in controls, but not patients. Considering that the VAN is thought to reflect reentrant processing, one interpretation of the findings is that patients’ lack of VAN response and poorer performance may be related to dysfunctional reentrant processing.
Developmental prosopagnosia: A case analysis and treatment study

This paper reports a treatment case study focused on face perception impairments designed for AL, an 8-year-old child with prosopagnosia. AL's prosopagnosia was characterized by deficits at the level of structural encoding—that is, he was unable to achieve normal basic perception of faces. This impairment then impacted on all subsequent aspects of familiar- and unfamiliar-face processing. Detailed assessment of feature processing revealed impairments in perception of facial features with a dissociation between relatively good perception of the mouth feature and poor perception of eye and nose features. Interestingly, results also suggested at least partial internal representation of facial features despite long-standing deficits in perception of these features. A treatment programme focused on training in perception, and analysis of facial features and familiar-face naming was conducted. Treatment resulted in excellent face naming for familiar faces, a decreased reliance on nonfacial cues and a reduction in AL's tendency to misidentify unfamiliar faces as family members.
An Automatic Image-Based Modelling Method Applied to Forensic Infography

This paper presents a new method based on 3D reconstruction from images that demonstrates the utility and integration of close-range photogrammetry and computer vision as an efficient alternative to modelling complex objects and scenarios of forensic infography. The results obtained confirm the validity of the method compared to other existing alternatives as it guarantees the following: (i) flexibility, permitting work with any type of camera (calibrated and non-calibrated, smartphone or tablet) and image (visible, infrared, thermal, etc.); (ii) automation, allowing the reconstruction of three-dimensional scenarios in the absence of manual intervention, and (iii) high quality results, sometimes providing higher resolution than modern laser scanning systems. As a result, each ocular inspection of a crime scene with any camera performed by the scientific police can be transformed into a scaled 3d model.
Transformational Leadership and Innovative Work Behaviour: Exploring the Relevance of Gender Differences

The importance of innovation within organizations has been demonstrated on numerous occasions, which has subsequently led to the identification of effective leadership as a potential catalyst. Accordingly, empirical findings have repeatedly demonstrated a positive relationship between transformational leadership and work unit effectiveness measures. This study explores the relationship between transformational leadership and employee innovative work behaviour, additionally examining the moderating effect of gender of the manager and gender of the employee. Data were gathered within four Australian hospitals, generating a dataset of 335 respondents. The findings revealed a positive and significant relationship between transformational leadership and innovative work behaviour. Furthermore, gender of the manager moderated the latter relationship, indicating that employees report more innovative behaviour when the transformational leadership is displayed by male in comparison with female managers, confirming our gender bias hypothesis. No significant effect was found for the three-way interaction of transformational leadership, gender of the manager, and gender of the employee. Implications and directions for future research are discussed.
The Protestant Work Ethic in Britain and Malaysia

Summary Two matched groups of British (N = 73) and Malaysian (N = 73) Ss completed the Mirels-Garrett Protestant ethic scale on which high scores indicate strong beliefs in the Protestant work ethic (PWE) and low scores, weak beliefs. Although there was no significant difference in scores between the three ethnic groups comprising the Malaysian sample (Malay, Indian, Chinese), there were large significant differences between the British and Malaysians: the former had less belief in the PWE. There were also significant sex differences—females had higher scores than males—and socioeconomic differences—working-class Ss had higher scores than middle-class Ss. The results are interpreted in terms of the previous studies of the Protestant work ethic in Asia and the social, cultural, and economic differences between Britain and Malaysia.
Cohort profile: the Jerusalem longitudinal cohort study.

Whilst it has been suggested that about 25% of the variability in human longevity is attributed to genetic influences, the remaining 75% is consequent upon a complex interplay of biological, environmental, social and culturally determined factors. In rising to the challenge of understanding the complexities of human ageing, a valuable tool to emerge in ageing research has been the longitudinal study, and early pioneering works in North America and Europe were instrumental in defining the emergence of modern geriatrics and gerontology. Undertaking such studies among diverse populations in different cultures is of value in furthering the understanding of universal ageing processes. Furthermore in many societies the oldest old are among the fastest growing sector of the population, and the need for basic definitions and descriptions of their patterns of need is a matter of pressing urgency for health care planners, ageing researchers and policy makers alike. After fruitful collaboration in the late 1980s with Alvar Svanborg, the leader of the Gottenberg Longitudinal Study of 70 year olds, we decided to initiate a long-term longitudinal study of ageing among Jerusalem residents, who are a uniquely heterogeneous elderly population, including immigrants from the America, Europe, Africa and Asia. The study, which was designed to follow a birth cohort from age 70 at baseline as they advanced with age, still remains the only such study of its kind both in scope and magnitude in the geographical region. Funding was provided in part by the Ministry of Health, the Ministry of Labor and Social Affairs, the National Insurance Institute (the Israeli Social Security administration), Eshel—the Association for the Planning and Development of Services for the Aged in Israel, as well as several private and charitable funds. Following a pilot feasibility study in 1989, with subsequent refinement of the study protocols and questionnaires, the Jerusalem Longitudinal Cohort study was established in 1990, with follow-up continuing up until the present time.
Do Empty Creditors Matter? Evidence from Distressed Exchange Offers

I examine the effect of credit default swaps (CDSs) on the restructuring of distressed firms. Theoretically, I show that if bondholders are insured with CDSs, the participation rate in a restructuring decreases. Using a sample of distressed exchange offers, I estimate that the participation rate is 29% lower if the firm has CDSs traded on its debt, compared to an unconditional mean of 54%. I use the introduction of the Big Bang protocol as a natural experiment. The results suggest that firms with CDSs find it difficult to reduce debt out-of-court, which is inefficient because it increases the likelihood of future bankruptcy.
Academic Procrastination: The Relationship Between Causal Attribution Styles and Behavioral Postponement

Objective: This research was conducted to study the relationship between attribution and academic procrastination in University Students. Methods: The subjects were 203 undergraduate students, 55 males and 148 females, selected from English and French language and literature students of Tabriz University. Data were gathered through Procrastination Assessment Scale-student (PASS) and Causal Dimension Scale (CDA) and were analyzed by multiple regression analysis (stepwise). Results: The results showed that there was a meaningful and negative relation between the locus of control and controllability in success context and academic procrastination. Besides, a meaningful and positive relation was observed between the locus of control and stability in failure context and procrastination. It was also found that 17% of the variance of procrastination was accounted by linear combination of attributions. Conclusion: We believe that causal attribution is a key in understanding procrastination in academic settings and is used by those who have the knowledge of Causal Attribution styles to organize their learning.
A scan-line algorithm for clustering line segments

Transformation of hardcopy ship drawings to electronic ones is usually accomplished through scanning and raster-to-vector conversions. Such conversions are, however, limited to produce low-degree vector entities, such as line segments, poly-lines and circular arcs. As a consequence, free-form curves, appearing in the original hardcopy, are usually disintegrated to a significant number of overlapping line and/or arc segments. The algorithm presented in this paper, consists of a scan-line processing of line segments that are grouped (clustered) with the aid of a moving scan-line and an appropriately defined distance to previously grouped entities. The performance of the algorithm is illustrated for the body-plan of a bulk carrier.
Surface X-Ray Diffraction Results on the III–V Droplet Heteroepitaxy Growth Process for Quantum Dots: Recent Understanding and Open Questions

In recent years, epitaxial growth of self-assembled quantum dots has offered a way to incorporate new properties into existing solid state devices. Although the droplet heteroepitaxy method is relatively complex, it is quite relaxed with respect to the material combinations that can be used. This offers great flexibility in the systems that can be achieved. In this paper we review the structure and composition of a number of quantum dot systems grown by the droplet heteroepitaxy method, emphasizing the insights that these experiments provide with respect to the growth process. Detailed structural and composition information has been obtained using surface X-ray diffraction analyzed by the COBRA phase retrieval method. A number of interesting phenomena have been observed: penetration of the dots into the substrate (“nano-drilling”) is often encountered; interdiffusion and intermixing already start when the group III droplets are deposited, and structure and composition may be very different from the one initially intended.
Infinite Superimposed Discrete All-Pole Modeling for Multipitch Analysis of Wavelet Spectrograms

This paper presents a statistical multipich analyzer based on a source-ﬁlter model that decomposes a target music audio signal in terms of three major kinds of sound quantities: pitch (fundamental frequency: F0), timbre (spectral envelope), and intensity (amplitude). If the spectral envelope of an isolated sound is represented by an all-pole ﬁlter, linear predictive coding (LPC) can be used for ﬁlter estimation in the linear-frequency domain. The main problem of LPC is that although only the amplitudes of harmonic partials are reliable samples drawn from the spectral envelope, the whole spectrum is used for ﬁlter estimation. To solve this problem, we propose an inﬁnite superimposed discrete all-pole (iSDAP) model that, given a music signal, can estimate an appropriate number of superimposed harmonic structures whose harmonic partials are drawn from a limited number of spectral envelopes. Our nonparametric Bayesian source-ﬁlter model is formulated in the log-frequency domain that better suits the frequency characteristics of human audition. Experimental results showed that the proposed model outperformed the counterpart model formulated in the linear frequency domain.
When Does Framing Influence Preferences, Risk Perceptions, and Risk Attitudes? The Explicated Valence Account

When faced with an expected loss and a choice between a sure option and a risky option, the gain–loss framing of the problem has been shown to influence option preference. According to prospect theory, this framing effect is the result of contradictory attitudes about risks involving gains and losses. This article develops and tests an alternative explicated valence account (EVA), which proposes that preference reversals are caused by differences in the explicated outcome valences of the options under consideration. EVA can account for previous findings where framing effects are observed, eliminated, or even reversed. In two experiments, EVA successfully predicted when framing effects were observed, eliminated, and reversed. The findings also showed that although framing influenced risk perception, it did not influence risk attitudes
Differential IFN-γ Stimulation of HLA-A Gene Expression through CRM-1-Dependent Nuclear RNA Export1

IFNs regulate most MHC class I genes by stimulating transcription initiation. As shown previously, IFN-γ controls HLA-A expression primarily at the posttranscriptional level. We have defined two 8-base sequences in a 39-nucleotide region in the 3′-transcribed region of the HLA-A gene that are required for the posttranscriptional response to IFN-γ. Stimulation of HLA-A expression by IFN-γ requires nuclear export of HLA-A mRNA by chromosome maintenance region 1 (CRM-1). Treatment of cells with leptomycin B, a specific inhibitor of CRM-1, completely inhibited IFN-γ induction of HLA-A. Expression of a truncated, dominant-negative form of the nucleoporin NUP214/CAN, ΔCAN, that specifically interacts with CRM-1, also prevented IFN-γ stimulation of HLA-A, providing confirmation of the role of CRM-1. Increased expression of HLA-A induced by IFN-γ also requires protein methylation, as shown by the fact that treatment of SK-N-MC cells or HeLa cells with the PRMT1 inhibitor 5′-methyl-5′-thioadenosine abolished the cellular response to IFN-γ. In contrast with HLA-A, IFN-γ-induced expression of the HLA class Ib gene, HLA-E, was not affected by either 5′-methyl-5′-thioadenosine or leptomycin B. These results provide proof of principle that it is possible to differentially modulate the IFN-γ-induced expression of the HLA-E and HLA-A genes, whose products often mediate opposing effects on cellular immunity to tumor cells, pathogens, and autoantigens.
[Acute hepatitis E in Madrid: description of 18 cases].

INTRODUCTION Hepatitis E virus (HEV) is the main cause of non-A non-B enterically transmitted hepatitis in underdeveloped countries but is rare in industrialized areas. However, in the last few years, several sporadic autochthonous hepatitis E cases have been reported in Europe and no risk factors, such as visiting to endemic areas, could be found in these patients. OBJECTIVE AND PATIENTS Twelve patients with sporadic autochthonous hepatitis E (no risk factors such as traveling to endemic areas) and six imported cases (travel to Nepal, Santo Domingo, China, Brazil and Ecuador) were studied between June 1999 and December 2005. RESULTS HEV infection was diagnosed in patients with symptoms of acute hepatitis and the presence of IgG and IgM antibodies in serum with no other markers of hepatitis. HEV infection is probably overlooked in industrialized countries. CONCLUSIONS This diagnosis should be suspected in patients with acute hepatitis and anti-HEV antibodies in serum without known risk factors such as traveling to endemic areas.