Miracle-dz/UniFAR-FTUs huggingface dataset:
Autonomy, Gender, Politics

Women have historically been prevented from living autonomously by systematic injustice, subordination, and oppression. The lingering effects of these practices have prompted many feminists to view autonomy with suspicion. Here, Marilyn Friedman defends the ideal of feminist autonomy. In her eyes, behavior is autonomous if it accords with the wants, cares, values, or commitments that the actor has reaffirmed and is able to sustain in the face of opposition. By her account, autonomy is socially grounded yet also individualizing and sometimes socially disruptive, qualities that can be ultimately advantageous for women. Friedman applies the concept of autonomy to domains of special interest to women. She defends the importance of autonomy in romantic love, considers how social institutions should respond to women who choose to remain in abusive relationships, and argues that liberal societies should tolerate minority cultural practices that violate women's rights so long as the women in question have chosen autonomously to live according to those practices.
Love, Sex, and Marriage: A Historical Thesaurus

If the language we use influences and reflects the way that we see the world, then the fields of LOVE, SEX, and MARRIAGE, will show how speakers of English view their closest social and emotional relationships. Love, Sex, and Marriage provides a classification of English terms for these three fields from the earliest written records of the language until the present day. This volume makes it possible to trace changing attitudes towards social and sexual ties, and to understand those ties as earlier speakers of English did, through the language they used. The terms are arranged by meaning, and are listed chronologically within semantic fields, with their dates of usage. Notes on individual terms provide further information about their connotations and development. Language does not exist in isolation from the people who speak it, so background information about changes in social conditions, religious beliefs, and medical advancements is also included. A brief introduction to basic semantic terminology explains the principles behind the classification, and an alphabetical index facilitates the location of individual terms.
Neuropsychiatric Manifestations in Mild Cognitive Impairment: A Systematic Review of the Literature

Background: Mild cognitive impairment (MCI) is an etiologically heterogeneous condition that is characterized by cognitive changes without impairment of activities of daily living and insufficient to represent dementia. MCI is an important risk state for dementia. Neuropsychiatric symptoms may be present in MCI. Methods: We executed a PubMed search for articles on the neuropsychiatric manifestations in MCI and reviewed their findings. Results: Behavioral abnormalities are reported in 35–75% of MCI patients with the most common being depression, apathy, anxiety and irritability. The observed variability in symptom prevalence can be explained by the different sampling methods, MCI diagnostic criteria and behavioral instruments used. There is a compelling body of evidence that MCI patients with behavioral features are more prone to develop Alzheimer’s disease (AD) than patients without these features. Conclusions: Neuropsychiatric symptoms are common features of MCI. The behavioral changes observed in MCI are similar to those of AD and may help identify the subgroup of MCI patients with prodromal AD. Large prospective longitudinal studies would greatly contribute to our understanding of the epidemiology, diagnostic and prognostic value of the neuropsychiatric features in MCI.
Experience with renal transplantation in the nonhuman primate: a modified ureteroneocystostomy to prevent urologic complications.

Nonhuman primates provide an optimal model for the evaluation of tolerance in the preclinical setting. Transplantation and management of nonhuman primates are technically demanding, and the purpose of this article is to review our extensive experience in renal transplantation in non-human primates, with particular emphasis on modifications of surgical techniques on urologic complications. We retrospectively reviewed our results with 329 renal transplants in rhesus monkeys over an 18-year period. The surgical technique and, in particular, the ureteroneocystostomy have evolved over this period of time. This review extensively details our current technique, the surgical and urologic complications, and their management. There were 329 renal transplants performed. There were 85 early deaths, or animals euthanized, within 30 days of the transplant operation. In the first 15 years, there were 27 (10.68%) surgical complications that required euthanasia, and in the last 3 years the complication rate has been reduced to 5 (7.3%, p < .05). The routine use of microsurgical techniques has reduced the incidence of arterial thrombosis (6.2% vs. 2.9%, p < .05). The incidence of ureteral strictures (15 vs. 0, p < .005) has been reduced by a modification of the ureteroneocystostomy technique detailed in the text. Renal transplantation in small rhesus monkeys is technically demanding. The routine use of microsurgical techniques and a modified ureteroneocystostomy has reduced the incidence of surgical complications.
Large model constructions for second-order ZF in dependent type theory

We study various models of classical second-order set theories in the dependent type theory of Coq. Without logical assumptions, Aczel’s sets-as-trees interpretation yields an intensional model of second-order ZF with functional replacement. Building on work of Werner and Barras, we discuss the need for quotient axioms in order to obtain extensional models with relational replacement and to construct large sets. Specifically, we show that the consistency strength of Coq extended by excluded middle and a description operator on well-founded trees allows for constructing models with exactly n Grothendieck universes for every natural number n. By a previous categoricity result based on Zermelo’s embedding theorem, it follows that those models are unique up to isomorphism. Moreover, we show that the smallest universe contains exactly the hereditarily finite sets and give a concise independence proof of the foundation axiom based on permutation models.
Scholars in Action : Past–Present–Future

This volume contains the contributions to a symposium on the conditions of research on the occasion of the Tercentary of the Royal Society of Sciences at Uppsala. After an introductory chapter on the early years of the Society, subsequent chapters present views of foreign members representing the Humanities, the Life Sciences, the Natural Sciences, and the Social Sciences. Comments on each of the chapters are provided by Swedish members. A concluding chapter discusses the influence of governments, markets and media on academic institutions.
Automatic learning of British Sign Language from signed TV broadcasts

In this work, we will present several contributions towards automatic recognition of BSL signs from continuous signing video sequences. Specifically, we will address three main points: (i) automatic detection and tracking of the hands using a generative model of the image; (ii) automatic learning of signs from TV broadcasts using the supervisory information available from subtitles; and (iii) generalisation given sign examples from one signer to recognition of signs from different signers. Our source material consists of many hours of video with continuous signing and corresponding subtitles recorded from BBC digital television. This is very challenging material for a number of reasons, including self-occlusions of the signer, self-shadowing, blur due to the speed of motion, and in particular the changing background. Knowledge of the hand position and hand shape is a pre-requisite for automatic sign language recognition. We cast the problem of detecting and tracking the hands as inference in a generative model of the image, and propose a complete model which accounts for the positions and self-occlusions of the arms. Reasonable configurations are obtained by efficiently sampling from a pictorial structure proposal distribution. The results using our method exceed the state-of-the-art for the length and stability of continuous limb tracking. Previous research in sign language recognition has typically required manual training data to be generated for each sign, e.g. a signer performing each sign in controlled conditions a time-consuming and expensive procedure. We show that for a given signer, a large number of BSL signs can be learned automatically from TV broadcasts using the supervisory information available from subtitles broadcast simultaneously with the signing. We achieve this by modelling the problem as one of multiple instance learning. In this way we are able to extract the sign of interest from hours of signing footage, despite the very weak and ”noisy” supervision from the subtitles. Lastly, we show that automatic recognition of signs can be extended to multiple signers. Using automatically extracted examples from a single signer, we train discriminative classifiers and show that these can successfully classify and localise signs in new signers. This demonstrates that the descriptor we extract for each frame (i.e. hand position, hand shape, and hand orientation) generalises between different signers. This thesis is submitted to the Department of Engineering Science, University of Oxford, in fulfilment of the requirements for the degree of Doctor of Philosophy. This thesis is entirely my own work, and except where otherwise stated, describes my own research. Patrick Buehler, Keble College Copyright c ©2010 Patrick Buehler All rights reserved
Insights into Arbovirus Evolution and Adaptation from Experimental Studies

Arthropod-borne viruses (arboviruses) are maintained in nature by cycling between vertebrate hosts and haematophagous invertebrate vectors. These viruses are responsible for causing a significant public health burden throughout the world, with over 100 species having the capacity to cause human disease. Arbovirus outbreaks in previously naïve environments demonstrate the potential of these pathogens for expansion and emergence, possibly exacerbated more recently by changing climates. These recent outbreaks, together with the continued devastation caused by endemic viruses, such as Dengue virus which persists in many areas, demonstrate the need to better understand the selective pressures that shape arbovirus evolution. Specifically, a comprehensive understanding of host-virus interactions and how they shape both host-specific and virus-specific evolutionary pressures is needed to fully evaluate the factors that govern the potential for host shifts and geographic expansions. One approach to advance our understanding of the factors influencing arbovirus evolution in nature is the use of experimental studies in the laboratory. Here, we review the contributions that laboratory passage and experimental infection studies have made to the field of arbovirus adaptation and evolution, and how these studies contribute to the overall field of arbovirus evolution. In particular, this review focuses on the areas of evolutionary constraints and mutant swarm dynamics; how experimental results compare to theoretical predictions; the importance of arbovirus ecology in shaping viral swarms; and how current knowledge should guide future questions relevant to understanding arbovirus evolution.
Characterization of pathogenesis of and immune response to Burkholderia pseudomallei K96243 using both inhalational and intraperitoneal infection models in BALB/c and C57BL/6 mice

Burkholderia pseudomallei, the etiologic agent of melioidosis, is a Gram negative bacterium designated as a Tier 1 threat. This bacterium is known to be endemic in Southeast Asia and Northern Australia and can infect humans and animals by several routes. Inhalational melioidosis has been associated with monsoonal rains in endemic areas and is also a significant concern in the biodefense community. There are currently no effective vaccines for B. pseudomallei and antibiotic treatment can be hampered by non-specific symptomology and also the high rate of naturally occurring antibiotic resistant strains. Well-characterized animal models will be essential when selecting novel medical countermeasures for evaluation prior to human clinical trials. Here, we further characterize differences between the responses of BALB/c and C57BL/6 mice when challenged with low doses of a low-passage and well-defined stock of B. pseudomallei K96243 via either intraperitoneal or aerosol routes of exposure. Before challenge, mice were implanted with a transponder to collect body temperature readings, and daily body weights were also recorded. Mice were euthanized on select days for pathological analyses and determination of the bacterial burden in selected tissues (blood, lungs, liver, and spleen). Additionally, spleen homogenate and sera samples were analyzed to better characterize the host immune response after infection with aerosolized bacteria. These clinical, pathological, and immunological data highlighted and confirmed important similarities and differences between these murine models and exposure routes.
Dual Processing in Reasoning

Human reasoning has been characterized as an interplay between an automatic belief-based system and a demanding logic-based reasoning system. The present study tested a fundamental claim about the nature of individual differences in reasoning and the processing demands of both systems. Participants varying in working memory capacity performed a reasoning task while their executive resources were burdened with a secondary task. Results were consistent with the dual-process claim: The executive burden hampered correct reasoning when the believability of a conclusion conflicted with its logical validity, but not when beliefs cued the correct response. However, although participants with high working memory spans performed better than those with lower spans in cases of a conflict, all reasoners showed similar effects of load. The findings support the idea that there are two reasoning systems with differential processing demands, but constitute evidence against qualitative individual differences in the human reasoning machinery.
Response of Burkholderia cenocepacia H111 to Micro-Oxia

B. cenocepacia is an opportunistic human pathogen that is particularly problematic for patients suffering from cystic fibrosis (CF). In the CF lung bacteria grow to high densities within the viscous mucus that is limited in oxygen. Pseudomonas aeruginosa, the dominant pathogen in CF patients, is known to grow and survive under oxygen-limited to anaerobic conditions by using micro-oxic respiration, denitrification and fermentative pathways. In contrast, inspection of the genome sequences of available B. cenocepacia strains suggested that B. cenocepacia is an obligate aerobic and non-fermenting bacterium. In accordance with the bioinformatics analysis we observed that B. cenocepacia H111 is able to grow with as little as 0.1% O2 but not under strictly anoxic conditions. Phenotypic analyses revealed that H111 produced larger amounts of biofilm, pellicle and proteases under micro-oxic conditions (0.5%–5% O2, i.e. conditions that mimic those encountered in CF lung infection), and was more resistant to several antibiotics. RNA-Seq and shotgun proteomics analyses of cultures of B. cenocepacia H111 grown under micro-oxic and aerobic conditions showed up-regulation of genes involved in the synthesis of the exopolysaccharide (EPS) cepacian as well as several proteases, two isocitrate lyases and other genes potentially important for life in micro-oxia. Data deposition: RNA-Seq raw data files are accessible through the GEO Series accession number GSE48585. MS data have been deposited in the ProteomeXchange database (PXD000270).
Animal characteristics of young , middle-aged , and old intact , OVX , and OVE rats

Amanda J. LeBlanc, Rafael Reyes, Lori S. Kang, Robert A. Dailey, John N. Stallone, Natasha C. Moningka, and Judy M. Muller-Delp Center for Cardiovascular and Respiratory Sciences, Division of Exercise Physiology, School of Medicine, Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, West Virginia; Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, Texas; and Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida
Retail clinics versus traditional primary care: Employee satisfaction guaranteed?

Purpose:To examine if differences exist in the levels of autonomy and job satisfaction among primary care nurse practitioners (NPs) employed in retail clinics versus traditional primary care settings. Data sources:Data were collected from 310 primary care NPs who attended the American Association of NP's 28th Annual Conference in June 2013. Participants completed a demographic form, the Misener NP Job Satisfaction Scale, and the Dempster Practice Behavior Scale. Conclusions:Overall, there were no differences in job satisfaction or autonomy among NPs by practice setting. Retail NPs felt less valued and were less satisfied with social interaction, but more satisfied with benefits compared to NPs in traditional settings. NPs working in retail clinics were less likely to have intentions to leave current position compared to NPs in traditional practice settings. Implications for practice:The results of this study enhance our current understanding of the linkages between levels of autonomy, job satisfaction, and practice setting among primary care NPs. The findings of this descriptive study offer valuable insights for stakeholders devoted to the development of the primary care workforce and identify modifiable factors that may influence retention and turnover rates among NPs.
Characterization of the major outer membrane antigens of Treponema hyodysenteriae

Outer membrane extracts of Treponema hyodysenteriae were used to evaluate the antibody responses in immunized or convalescent pigs. Western blot (immunoblot) analysis identified antibodies in sera reactive with 14- to 19-kilodalton (kDa) antigens. Reactivity against these antigens could be removed only by absorption of sera with butanol-water-extracted endotoxin from the homologous strain of T. hyodysenteriae. Treatment of the outer membrane extracts with 0.1 M sodium meta-periodate, but not with proteinase K, abolished reactivity with both outer membrane and endotoxin antigens (14 and 19 kDa). These results indicate that swine vaccinated with the outer membrane extract of T. hyodysenteriae develop antibody responses to outer membrane antigens qualitatively similar to those of swine convalescing from active infection, especially antibodies against low-molecular-mass antigens. The nature of the 14- to 19-kDa antigens appears consistent with that of treponemal endotoxin and lipopolysaccharide.
A controlled trial of homocysteine lowering and cognitive performance.

BACKGROUND The results of observational studies suggest that plasma homocysteine concentrations are inversely related to cognitive function in older people. Our objective was to test the hypothesis that lowering the plasma homocysteine concentration improves cognitive function in healthy older people. METHODS We conducted a two-year, double-blind, placebo-controlled, randomized clinical trial involving 276 healthy participants, 65 years of age or older, with plasma homocysteine concentrations of at least 13 micromol per liter. Homocysteine-lowering treatment was a daily supplement containing folate (1000 microg) and vitamins B12 (500 microg) and B6 (10 mg). Tests of cognition were conducted at baseline and after one and two years of treatment. Treatment effects were adjusted for baseline values, sex, and education. RESULTS On average, during the course of the study, the plasma homocysteine concentration was 4.36 micromol per liter (95 percent confidence interval, 3.81 to 4.91 micromol per liter) lower in the vitamin group than in the placebo group (P<0.001). Overall, there were no significant differences between the vitamin and placebo groups in the scores on tests of cognition. CONCLUSIONS The results of this trial do not support the hypothesis that homocysteine lowering with B vitamins improves cognitive performance. (Australian Clinical Trials registry number, ACTR NO 12605000030673.).
FAMINE OEDEMA

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Charms of the cynical reason : the trickster's transformations in Soviet and post-Soviet culture

The impetus for Charms of the Cynical Reason is the phenomenal and little-explored popularity of various tricksters flourishing in official and unofficial Soviet culture, as well as in the post-soviet era. Mark Lipovetsky interprets this puzzling phenomenon through analysis of the most remarkable and fascinating literary and cinematic images of soviet and post-soviet tricksters, including such "cultural idioms" as Ostap Bender, Buratino, Vasilii Tyorkin, Shtirlitz, and others. The steadily increasing charisma of Soviet tricksters from the 1920s to the 2000s is indicative of at least two fundamental features of both the soviet and post-soviet societies. First, tricksters reflect the constant presence of irresolvable contradictions and yawning gaps within the soviet (as well as post-soviet) social universe. Secondly, these characters epitomize the realm of cynical culture thus far unrecognized in Russian studies. Soviet tricksters present survival in a cynical, contradictory and inadequate world, not as a necessity, but as a field for creativity, play, and freedom. Through an analysis of the representation of tricksters in soviet and post-soviet culture, Lipovetsky attempts to draw a virtual map of the soviet and post-soviet cynical reason: to identify its symbols, discourses, contradictions, and by these means its historical development from the 1920s to the 2000s.