Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of corneal epitheliotrophic capacities among human platelet lysates and other blood derivatives

Purpose To evaluate the corneal epitheliotropic abilities of two commercialized human platelet lysates (HPLs) and to compare the results with other blood derivatives, including human peripheral serum (HPS) and bovine fetal serum (FBS). Methods In vitro, human corneal epithelial cells were incubated in various concentrations (0%, 3%, 5% and 10%) of blood derivatives. Two commercialized HPLs, including UltraGRO TM (Helios, Atlanta, GA) and PLTMax (Mill Creek, Rochester, MI), were tested and compared with HPS and FBS. Scratch-induced directional wounding assay was performed to evaluate cellular migration. MTS assay was used to evaluate cellular proliferation. Cellular differentiation was examined by scanning electron microscopy, inverted microscopy and transepithelial electrical resistance. Sprague-Dawley rats were used to evaluate the effects of the blood derivatives on corneal epithelial wound healing in vivo. Different blood derivatives were applied topically every 2 hours for 2 days after corneal epithelial debridement. The concentrations of epidermal growth factor (EGF), transforming growth factor -β1 (TGF-β1), fibronectin, platelet-derived growth factor-AB (PDGF-AB), PDGF-BB, and hyaluronic acid in different blood derivatives were evaluated by enzyme-linked immunosorbent assay (ELISA). Results In vitro experiments demonstrated statistically comparable epitheliotropic characteristics in cellular proliferation, migration, and differentiation for the two commercialized HPLs compared to FBS and HPS. Cells cultured without any serum were used as control group. The epitheliotropic capacities were statistically higher in the two commercialized HPLs compared to the control group (p<0.05). Among the different concentrations of blood derivatives, the preparations with 3% yielded better outcomes compared to 5% and 10%. In rats, HPLs also caused improved but not statistically significant wound healing compared to HPS. All the blood derivatives had better wound healing ratios than the control group (p<0.05). In the quantification of epitheliotropic factors, UltraGRO and PLTMax had significantly higher levels of EGF, TGF- β1, fibronectin than human peripheral serum (p<0.05). Conclusions Both commercialized HPLs showed comparable corneal epitheliotropic abilities and wound healing rates compared to HPS and FBS in the in vivo and in vitro studies. Our results suggest that HPLs may have the potential to replace HPS in the treatment of corneal epithelial problems.
ApoE-4 and Age at Onset of Alzheimer's Disease

Objective: To explore the impact of apoE-4 on Alzheimer's disease (AD) and its age at onset. Design: A genetic linkage study using affected relative pairs, predominantly siblings. Setting: Three academic medical centers ascertained subjects from memory disorder clinics, nursing homes, and the local community. Subjects: 310 families including 679 subjects with AD by NINCDS/ADRDA and/or Khachaturian criteria and 231 unaffected subjects. Outcome measure: ApoE genotype. Analytic methods: Association, affected pedigree member, sibling pair, and lod score analyses. Results: ApoE-4 was strongly associated with AD in this sample (allele frequency = 0.46 vs. 0.14 in controls, p < 0.000001). Results of lod score, affected pedigree member analysis, and sib-pair analysis also supported apoE-4 as a risk factor for AD. When the sample was stratified on family mean age at onset, the risk conferred by apoE-4 was most marked in the 61 to 65 age group. Individuals with two copies of apoE-4 had a significantly lower age at onset than those with one or no copies (66.4 vs. 72.0, p < 0.001), but individuals with one copy did not differ from those with none. Within families, the individual with the earliest age at onset had, on average, significantly more apoE-4 alleles (p < 0.0001) than the individual with the latest onset. Discussion: This work supports previous reports of an association between apoE-4 and the development of AD and demonstrates that apoE-4 exerts its maximal effect before age 70. These findings have important implications for the potential use of apoE genotyping for diagnosis and prediction of disease. They also underscore the need to identify additional genetic factors involved in AD with onset beyond age 70 years. NEUROLOGY 1997;48: 139-147
Assessing Knowledge Management: Refining and Cross Validating the Knowledge Management Index Using Structural Equation Modeling Techniques

With growing interest in knowledge management (KM)-related assessments and calls for rigorous as-sessment tools, the objective of this study was to apply structural equation modeling (SEM) techniques to refine and cross validate the KM index (KMI), a metric to assess the degree to which organizations are engaged in KM. Unlike previous KM metrics research that has focused on scales, we modeled the KMI as a formative latent variable, thereby extending knowledge on formative measures and index creation from other fields into the KM field. The refined KMI metric was tested in a nomological network and found to be robust and stable when cross validated; thereby demonstrating consistent prediction results across independent data sets. The study also verified the hypothesis that the KMI is positively correlated with organizational performance (OP). Research contributions, managerial implications, limitations of the study, and direction for further research are discussed.
The inheritance of scholastic abilities in a sample of twins I. Ascertainment of the sample and diagnosis of zygosity

A sample of 149 twin pairs was ascertained by extracting all pairs of candidates with the same surname, birth date and address from the files of a public examination taken by about two thirds of the 15-year-old cohort in South Australia. Of these there were 39 opposite sex pairs and 100 same-sex pairs whose zygosity was determined by postal questionnaire. This diagnosis was checked and found to be accurate by typing 47 pairs for ten independent genetic markers. Several analyses suggest that the ascertained twin samples is fairly representative of the fraction of the cohort who took the examination so there is no evidence to suggest that between families components of variance will be underestimated for this reason.
The Voices of Latino Families Raising Children With Special Needs

In this study we examined the perceptions of 16 Latino families regarding their views and experiences raising a child with special needs and their involvement in their child's schooling. Families talked about treating their child like a “normal child” regardless of the child's unique needs, but they also stated that their level of involvement was different compared to raising their other children. All families shared their expectations for their child, with most wanting their child to reach a level of independence. Overall, families were satisfied with the special education program; however, some families were concerned with the progress their child was making.
Journal of Enterprise Information Management

For Authors: If you would like to write for this, or any other Emerald publication, then please use our Emerald for Authors service. Information about how to choose which publication to write for and submission guidelines are available for all. Please visit About Emerald www.emeraldinsight. com With over forty years' experience, Emerald Group Publishing is a leading independent publisher of global research with impact in business, society, public policy and education. In total, Emerald publishes over 275 journals and more than 130 book series, as well as an extensive range of online products and services. Emerald is both COUNTER 3 and TRANSFER compliant. The organization is a partner of the Committee on Publication Ethics (COPE) and also works with Portico and the LOCKSS initiative for digital archive preservation.
The use of a portable breath analysis device in monitoring type 1 diabetes patients in a hypoglycaemic clamp: validation with SIFT-MS data

Monitoring blood glucose concentrations is a necessary but tedious task for people suffering from diabetes. It has been noted that breath in people suffering with diabetes has a different odour and thus it may be possible to use breath analysis to monitor the blood glucose concentration. Here, we evaluate the analysis of breath using a portable device containing a single mixed metal oxide sensor during hypoglycaemic glucose clamps and compare that with the use of SIFT-MS described in previously published work on the same set of patients. Outputs from both devices have been correlated with the concentration of blood glucose in eight volunteers suffering from type 1 diabetes mellitus. The results demonstrate that acetone as measured by SIFT-MS and the sensor output from the breath sensing device both correlate linearly with blood glucose; however, the sensor response and acetone concentrations differ greatly between patients with the same blood glucose. It is therefore unlikely that breath analysis can entirely replace blood glucose testing.
NCAM polypeptides in heart development: association with Z discs of forms that contain the muscle-specific domain

Previous studies of neural cell adhesion molecule (NCAM) cDNAs have revealed an alternatively spliced set of small exons (12A, 12B, 12C, and 12D) that encode a region in the extracellular portion of the molecule known as the muscle-specific domain (MSD). The entire MSD region can be expressed in skeletal muscle, heart, and skin; only exons 12A and 12D have been found in brain. These studies did not reveal which NCAM polypeptides contain the MSD region or the immunohistochemical distribution of these NCAM molecules. To address these questions, we prepared antibodies against the oligopeptides encoded by exons 12A and 12B and by exons 12C and 12D, and we used these antibodies to study the forms of NCAM containing the MSD region expressed during embryonic chicken heart development. These antibodies recognize certain forms of NCAM found in the heart, but they do not recognize brain NCAM. In the heart, each of the splice variants of NCAM (large cytoplasmic domain, small cytoplasmic domain, and small surface domain) that differ in their mode of attachment to the plasma membrane or in the size of their cytoplasmic domain is expressed in a form that contains and in a form that lacks the MSD region. No microheterogeneity is observed in the size of NCAM molecules containing the MSD region, even at the level of cyanogen bromide fragments, suggesting that exons 12A-D are expressed as a single unit. Depending on the site and the stage of development, the percent of NCAM molecules containing the MSD region can vary from nearly 0 to 100%. In general, this percentage increases during development. In immunohistochemical studies of hearts from stage 18 embryos, forms of NCAM containing the MSD region colocalized with Z discs. No other adhesion molecules were found in this distribution at this early stage of development. Studies on isolated cells in vitro demonstrate that the colocalization with Z discs of NCAM molecules containing the MSD region does not depend on cell-cell contact, and they raise the possibility that this form of NCAM is involved in cell-extracellular matrix interactions. The association of NCAM molecules containing the MSD region with Z discs suggests that this form of NCAM is involved in early myofibrillogenesis.
African Americans’ Lay Theories About the Detection of Prejudice and Nonprejudice

Two studies examine African Americans’ perceptions of prejudice and nonprejudice in Whites and their perceptions of Whites’ impression management behaviors related to prejudice. Responses to open-ended questions about what makes them think a person is and is not prejudiced and general advice for Whites were collected from a total of 236 African American university students. The most common behaviors listed that indicated prejudice included name calling and stereotyping. Indications of nonprejudice included positive behaviors (smiling, helping), equal treatment, and seeking out interaction with minorities. Respondents also advised Whites to be authentic. Results also indicated that common impression management behaviors by Whites may backfire. Results are discussed in terms previous research and the complicated nature of interracial interactions.
NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast

NAP1 is a 60-kD protein that interacts specifically with mitotic cyclins in budding yeast and frogs. We have examined the ability of the yeast mitotic cyclin Clb2 to function in cells that lack NAP1. Our results demonstrate that Clb2 is unable to carry out its full range of functions without NAP1, even though Clb2/p34CDC28-associated kinase activity rises to normal levels. In the absence of NAP1, Clb2 is unable to efficiently induce mitotic events, and cells undergo a prolonged delay at the short spindle stage with normal levels of Clb2/p34CDC28 kinase activity. NAP1 is also required for the ability of Clb2 to induce the switch from polar to isotropic bud growth. As a result, polar bud growth continues during mitosis, giving rise to highly elongated cells. Our experiments also suggest that NAP1 is required for the ability of the Clb2/p34CDC28 kinase complex to amplify its own production, and that NAP1 plays a role in regulation of microtubule dynamics during mitosis. Together, these results demonstrate that NAP1 is required for the normal function of the activated Clb2/p34CDC28 kinase complex, and provide a step towards understanding how cyclin- dependent kinase complexes induce specific events during the cell cycle.
Depth Map Rasterization Using Triangulation and Color Consistency for Various Sampling Structures

The reconstruction of a dense depth map from sparsely sampled depth information has been studied to improve stereoscopic 3-D images. Among various sparse-to-dense depth map reconstruction methods, triangular-patch-based approaches have been widely used. However, the triangular-patch-based approaches suffer from a limitation in preserving depth discontinuities, because they assume that each triangular patch has a planar depth map. This paper presents a novel depth map rasterization method that considers the depth discontinuities and color consistencies in each triangular patch. The results of the experiment show that the proposed depth map rasterization method reconstructs dense depth maps with higher accuracy than the previous depth map upsampling methods for both regular and irregular depth map sampling structures.
Differential Functional Adaptations to Short-Term Low-, Moderate-, and High-Repetition Weight Training

Previously untrained young men (n 5 38) were compared in terms of selected changes in leg function following 7 weeks of differential repetition exposures during heavyresistance training. Subjects were randomly placed into 1 of 4 groups. Groups I, II, and III completed 3 workouts per week, including a warm-up and 4 sets of squats for a 3‐5 repetitions maximum (3‐5RM), 13‐15RM, or 23‐ 25RM, respectively. A fourth (control) group did not participate in formal physical training during this interim. Selected tests of leg function included dynamic constant external resistance (DCER) squat strength, isokinetic knee extension and flexion peak torque at both 60 and 3008·s 21 , and vertical jump. Following the 7-week training period, both DCER squat strength and knee extension peak torque at 608·s21 were significantly increased in all 3 treatment groups more (p , 0.01) than in the control group. In addition, squat strength was improved more in group I than in group III (p , 0.05). No significant differences (p . 0.05) were found between any of the 4 groups for changes in either vertical jump distance, knee extension and flexion peak torque at 3008·s21 , or knee flexion peak torque at 608·s21 . These results indicate that short-term low-, moderate-, and high-repetition heavy-resistance squat training programs have little effect on jumping distance or highvelocity strength but do enhance DCER squat strength and maximal low-velocity knee extension strength. In addition, the low-repetition program appears to be superior to the high-repetition program for improving squat strength. The absence of improvements in vertical jump distance and fast-velocity isokinetic knee extension and flexion peak torque suggests that short-term DCER weight training, performed as described above, may have minimal direct impact on ‘‘explosive’’ physical activities for young men having limited training experience.
Periprosthetic fractures in total ankle replacement: classification system and treatment algorithm.

BACKGROUND Despite progress in implant design and surgical technique, the reported number of periprosthetic ankle fractures following total ankle joint replacement continues to increase. A treatment-oriented classification of these fractures has not yet been reported. The purpose of this study was to evaluate the prevalence, cause, and location of periprosthetic fractures and the stability of the associated prosthetic components after total ankle replacement and to develop a method of classification. METHODS Data regarding 503 total ankle replacements with a mean follow-up of 14.7 months were reviewed. The prevalence, location, and possible cause of the fractures as well as prosthesis stability were analyzed and a systematic method of classification based on these factors was developed. RESULTS Twenty-one patients (4.2%) with a periprosthetic fracture were identified. The fracture was intraoperative (Type 1) in eleven patients (2.2%) and postoperative in the remaining ten (2.0%). Two of the latter fractures were traumatic (Type 2) and eight were stress fractures (Type 3). Two-thirds (fourteen) of the twenty-one fractures occurred in the medial malleolus. CONCLUSIONS The prevalence of periprosthetic fractures following primary total ankle replacement was relatively low. We propose a classification system for these fractures that is based on more than 500 cases. We believe that this classification can facilitate therapeutic decision-making, as it allows for differential analysis of the cause and guides the choice among operative and nonoperative treatment options.
RESEARCHING RESISTANCE: CAMPAIGNS AGAINST ACADEMIES IN ENGLAND

ABSTRACT: This article uses social movement theory to analyse campaigns against a new type of government-sponsored school – the Academy – in four areas of England. It seeks to identify the social composition of anti-Academy campaigns, to track their encounters with proponents of the new schools and to describe the characteristic forms of their campaigning strategies. In doing so, the article aims to help place research into educational opposition and contestation closer to the centre of researchers’ agendas.
A Systematization of the Literature on Entrepreneurship Education

This article reviews the literature on entrepreneurship education in the higher education context published over the first decade of the 2000s. The article has two purposes: to propose a framework of analysis to systematize and assess the literature; and to examine its main insights and contributions towards practice in the entrepreneurial classroom. The first decade of the 2000s is particularly relevant because it witnessed significant developments in the theoretical and empirical frameworks for the assessment of entrepreneurship education programmes and methodologies. The authors find that a very significant share of the research on entrepreneurship education over the period of analysis has sought to evaluate its results. There is not yet a consistent body of knowledge that can provide general insights and tools for practice. Practitioners need to pick and choose among pedagogical approaches and methods to select those that best suit their particular context.
The Preceding Voltage Pulse and Separation Welding Mechanism of Electrical Contacts

In order to obtain a better understanding of the welding mechanism in contact separation, electrical endurance tests were conducted with AgSnO2 and AgNi contacts on a simulation test device. Waveforms of contact displacement, contact voltage, and current were recorded with LabVIEW during the tests, and changes in a contact gap and heights of pips with increases in operation cycles were observed through charge-coupled device cameras. The resultant test results show that welding in separation is accompanied with a preceding voltage pulse which represents arc rather than contact bounce arc.
How Can We Improve School Safety Research?

The authors of this article consider how education researchers can improve school violence and school safety research by (a) examining gaps in theoretical, conceptual, and basic research on the phenomena of school violence; (b) reviewing key issues in the design and evaluation of evidence-based practices to prevent school violence; and (c) suggesting new directions for a translational science agenda that can inform policy and practice. The authors describe international empirical approaches that help match annual school safety monitoring data with specific evidence-based practices for each school site, school district, or region. The systemic exploration of successful large-scale applications of evidence-based programs at the district, regional, and state levels could inform theoretical paradigms, empirical databases, and practice.
Social Learning Theory: A Psychological Approach to Advertising Effectiveness?

Most of the current research on consumer reactions to advertisements has utilized explanations based on advertising models of consumer behaviour. The present study assessed the utility of social learning theory approaches to advertising effectiveness. Orthogonal 2 times; 2 × 2 times; 2 (race of model × sexiness of model × race of observer × sex of observer) ANOVAs were computed on 160 subjects' recall of an advertisement, attitudes to that advertisement, and purchase intention following exposure to the advertisement. In considering the various two-way and higher-order interactions that emerged, it was concluded that a framework of social learning theory may account for the findings. Specifically, the interaction between behaviour, the environment, and cognitive events influencing perception and action, together with the situational specificity hypotheses adequately explain consumer reactions to advertising. It is suggested that other social learning constructs such as response-outcome expectations, their valence, and the delay of gratification paradigm may further explain such behaviour.
Media Publicity and Civil Society: Nonprofit Organizations, Local Newspapers and the Internet in a Midwestern Community

Media attention to the voluntary sector depends mainly on organizational resources of nonprofit organizations that can influence organizations' positions in a local community power structure. Relying on the resource dependency theory (Pfeffer & Salancik, 1978) as a conceptual framework, this study examines to what extent various features of nonprofit organizations yield different levels of media publicity through local newspapers and the Internet in a Midwestern community. Data were collected using multiple research methods, including public archive analysis, telephone and e-mail surveys, news archive analysis, and hyperlink analysis (N = 218). Hierarchical multiple regression analyses reveal that financially resource-rich, locally embedded organizations and organizations with larger numbers of directors and volunteers tend to receive more newspaper coverage. Analyses also indicate that nonlocal groups tend to receive more hyperlinks from other Web sites. Implications for media and voluntary associations in a civil society context are discussed.