Miracle-dz/UniFAR-FTUs huggingface dataset:
Structure and Overlaps of Communities in Networks

One of the main organizing principles in real-world social, information and technological networks is that of network communities, where sets of nodes organize into densely linked clusters. Even though detection of such communities is of great interest, understanding the structure communities in large networks remains relatively limited. Due to unavailability of labeled ground-truth data it is practically impossible to evaluate and compare different models and notions of communities on a large scale. In this paper we identify 6 large social, collaboration, and information networks where nodes explicitly state their community memberships. We define ground-truth communities by using these explicit memberships. We then empirically study how such ground-truth communities emerge in networks and how they overlap. We observe some surprising phenomena. First, ground-truth communities contain high-degree hub nodes that reside in community overlaps and link to most of the members of the community. Second, the overlaps of communities are more densely connected than the non-overlapping parts of communities, in contrast to the conventional wisdom that community overlaps are more sparsely connected than the communities themselves. Existing models of network communities do not capture dense community overlaps. We present the Community-Affiliation Graph Model (AGM), a conceptual model of network community structure, which reliably captures the overall structure of networks as well as the overlapping nature of network communities.
Suppressed Production of Soluble Fms-Like Tyrosine Kinase-1 Contributes to Myocardial Remodeling and Heart Failure

Soluble fms-like tyrosine kinase-1 (sFlt-1), an endogenous inhibitor of vascular endothelial growth factor and placental growth factor, is involved in the pathogenesis of cardiovascular disease. However, the significance of sFlt-1 in heart failure has not been fully elucidated. We found that sFlt-1 is decreased in renal failure and serves as a key molecule in atherosclerosis. In this study, we aimed to investigate the role of the decreased sFlt-1 production in heart failure, using sFlt-1 knockout mice. sFlt-1 knockout mice and wild-type mice were subjected to transverse aortic constriction and evaluated after 7 days. The sFlt-1 knockout mice had significantly higher mortality (52% versus 15%; P=0.0002) attributable to heart failure and showed greater cardiac hypertrophy (heart weight to body weight ratio, 8.95±0.45 mg/g in sFlt-1 knockout mice versus 6.60±0.32 mg/g in wild-type mice; P<0.0001) and cardiac dysfunction, which was accompanied by a significant increase in macrophage infiltration and cardiac fibrosis, than wild-type mice after transverse aortic constriction. An anti–placental growth factor–neutralizing antibody prevented pressure overload–induced cardiac hypertrophy, fibrosis, and cardiac dysfunction. Moreover, monocyte chemoattractant protein-1 expression was significantly increased in the hypertrophied hearts of sFlt-1 knockout mice compared with wild-type mice. Monocyte chemoattractant protein-1 inhibition with neutralizing antibody ameliorated maladaptive cardiac remodeling in sFlt-1 knockout mice after transverse aortic constriction. In conclusion, decreased sFlt-1 production plays a key role in the aggravation of cardiac hypertrophy and heart failure through upregulation of monocyte chemoattractant protein-1 expression in pressure-overloaded heart.
Long-QT Syndrome-Associated Missense Mutations in the Pore Helix of the HERG Potassium Channel

Background—Mutations in the human ether-à-go-go-related gene (HERG) cause chromosome 7-linked long-QT syndrome (LQTS), an inherited disorder of cardiac repolarization that predisposes affected individuals to arrhythmia and sudden death. Methods and Results—Here, we characterize the physiological consequences of 3 LQTS-associated missense mutations (V612L, T613M, and L615V) located in the pore helix of the HERG channel subunit. Mutant HERG subunits were heterologously expressed in Xenopus oocytes alone or in combination with wild-type HERG subunits. Two-microelectrode voltage-clamp techniques were used to record currents, and a single oocyte chemiluminescence assay was used to assay surface expression of epitope-tagged subunits. When expressed alone, V612L and T613M HERG subunits did not induce detectable currents, and L615V induced very small currents. Coexpression of mutant and wild-type HERG subunits caused a dominant-negative effect that varied for each mutation. Conclusions—These findings define the physiological consequences of mutations in HERG that cause LQTS and indicate the importance of the pore helix of HERG for normal channel function.
Sense of Community Among Individuals in Substance Abuse Recovery

This study assessed the psychometric properties of the Perceived Sense of Community Scale (PSCS). Psychological sense of community is a construct that has been developed primarily in the field of community psychology and deals with the feelings of connectedness, group membership, and need fulfillment that members of small groups or larger communities may have toward other members. The current research explores this concept in the evaluation of Oxford Houses, residential homes designed to provide mutual support to individuals recovering from substance abuse and dependence, through the use of the PSCS. Overall, the PSCS was a multidimensional scale exhibiting a cluster of negatively phrased items with a large number of highly loading items. Within the three-factor structure, two factors were nearly perfectly correlated, and neither sex nor race bias affected the initial formulation. However, sex and race were significant (but of small magnitude) covariates in a later sample, and highly reliable subscales were formulated with five items. Taken together, the PSCS was capable of performing as an acceptable measurement model in latent analysis.
Genetically Diverse Group A Streptococci from Children in Far-Western Nepal Share High Genetic Relatedness with Isolates from Other Countries

ABSTRACT The genetic diversity of group A streptococci (GAS) throughout much of the world has not been adequately explored. To assess genetic variation among GAS in western Nepal, 120 noninvasive GAS, collected from eight different villages, were genetically characterized using emm typing, sof sequencing, and multilocus sequence typing (MLST). A high level of genetic diversity was observed among these isolates, with 51 genotypes based upon 51 multilocus sequence types (STs), 45 emm sequence types, and 28 sof sequence types. On the basis of shared ST-emm and sof-emm associations, 40 of the 51 genotypes were identical or highly related to genotypes characterized from locations outside of Nepal, even though most of the emm sequence and clonal types are rare among GAS within the United States. When analyzing all known STs highly related to Nepal STs, only one example of similar STs shared between a sof PCR-positive strain and a sof PCR-negative strain was observed. Since previous data indicate free exchange of MLST loci between sof-positive and sof-negative strains, there is possibly selection against the expansion of subclones resulting from horizontal transfers of sof or emm genes between sof-positive and sof-negative strains. All 45 emm types encountered in Nepal have also been documented from other countries. These data, together with data encompassing the past decade of emm type surveillance, support the possibility that most existing GAS emm types have been discovered. Similarly, since most (40/51) strain types were highly related to strains found elsewhere, it is likely that a major fraction of the existing GAS clonal complexes have been discovered.
Inferring confidence sets of possibly misspecified gene trees

The problem of inferring confidence sets of gene trees is discussed without assuming that the substitution model or the branching pattern of any of the investigated trees is correct. In this case, widely used methods to compare genealogies can give highly contradicting results. Here, three methods to infer confidence sets that are robust against model misspecification are compared, including a new approach based on estimating the confidence in a specific tree using expected–likelihood weights. The power of the investigated methods is studied by analysing HIV–1 and mtDNA sequence data as well as simulated sequences. Finally, guidelines for choosing an appropriate method to compare multiple gene trees are provided.
Validação de escala de estratégias de aprendizagem no trabalho entre prefeitos(as) e secretários(as) municipais

At the workplace, individuals are increasingly expected to be able to learn how to learn and to take the initiative of their own learning process. In this context, understanding of individual factors related to learning gains in importance. This report describes the adaptation and validation of an instrument for the measurement of one of these factors, denominated learning strategies at work, understood as the efforts undertaken by the individual to carry out his or her own learning process in working contexts. Based on a scale already validated in a banking sector organization, the adapted measure was applied to a sample of 90 Mayors and 365 Municipal Secretaries, due to the huge learning demand imposed to them by their working conditions. Results of factor analysis indicated a five factor structure (extrinsic and intrinsic reflection, search for help in written material, search for interpersonal help, practical application and reproduction) that is consistent with the results obtained with other samples.
Evaluación de servicios educativos: El rendimiento en los centros públicos y privados medido en PISA-2003

The main aim of this paper is to examine the effect of the educational institution, and, specifically, its public or private ownership on the results of the Spanish education system. The empirical analysis is based on the application of multilevel regression techniques on data from OECD PISA-2003. The results of the analysis support the working hypothesis, in which it is stated that the best performance of private institution pupils are not explained by ownership, but rather by variables such as the individual and family characteristics of the users, their peers, and other variables related to the institution.
Power matters: Automatic Gain Control for a Software Defined Radio IEEE 802.11a/g/p receiver

Software Defined Radios (SDRs) have become a fundamental building block for research on wireless networks. Yet, using this platform for experiments in the field is hindered by many practical difficulties, an important one being the need for Automatic Gain Control (AGC). We demonstrate a way of implementing an AGC algorithm directly in the FPGA where we are able to meet tough timing constraints. This allows using SDRs not just for lab experiments but also for measurement campaigns or deployments in the field.With extending our GNURadio-based Open Source stack for IEEE 802.11a/g/p WLAN with AGC, we provide an SDR platform that can be integrated into existing WiFi networks just as well as into future vehicular networks.
Link-time static analysis for efficient separate compilation of object-oriented languages

Compilers used in industry are mainly based on a separate compilation framework. However, the knowledge of the whole program improves efficiency of object-oriented language compilers, therefore more efficient implementation techniques are based on a global compilation framework.In this paper, we propose a compromise by including three global compilation techniques (type analysis, coloring and binary tree dispatching) in a separate compilation framework. Files are independently compiled into standard binary files with unresolved symbols. The program is build by linking object files: files are gathered and analyzed, some link code is generated then symbols are resolved.
Causal hierarchy of spacetimes, temporal functions and smoothness of Geroch's splitting. A revision

After the heroic epoch of Causality Theory, problems concerning the smoothability of time functions and Cauchy hypersurfaces remained as unanswered folk questions. Just recently solved, our aim is to discuss the state of the art on this topic, including self-contained proofs for questions on causally continuous, stably causal and globally hyperbolic spacetimes.
Periodic Oscillation for Cohen-Grossberg-Type Bidirectional Associative Memory Neural Networks with Neutral Time-Varying Delays

In this paper, a model describing dynamics of Cohen-Grossberg-type bidirectional associative memory neural networks with neutral time-varying delays is investigated by using the continuation theorem of Mawhin's coincidence degree theory and the properties of an $M$-matrix. Without assuming the continuous differentiability of time-varying delays, some sufficient conditions on the existence of the periodic solutions are obtained. The result of this paper is new and extent previously known result. Finally, an illustrative example is given to show the effectiveness of the obtained result.
Levels of Inflammatory Cytokines in Type 2 Diabetes Patients with Different Urinary Albumin Excretion Rates and Their Correlation with Clinical Variables

Although the pathogenetic mechanism of DN has not been elucidated, an inflammatory mechanism has been suggested as a potential contributor. This study was designed to explore the relationship between low-grade inflammation and renal microangiopathy in T2DM. A total of 261 diabetic subjects were divided into three groups according to UAE: a normal albuminuria group, a microalbuminuria group, and a macroalbuminuria group. A control group was also chosen. Levels of hs-CRP, TNF-α, uMCP-1, SAA, SCr, BUN, serum lipid, blood pressure, and HbA1c were measured in all subjects. Compared with the normal controls, levels of hs-CRP, TNF-α, uMCP-1, and SAA in T2DM patients were significantly higher. They were also elevated in the normal albuminuria group, P < 0.05. Compared with the normal albuminuria group, levels of these inflammatory cytokines were significantly higher in the microalbuminuria and macroalbuminuria group, P < 0.01. The macroalbuminuria group also showed higher levels than the microalbuminuria group, P < 0.01. Also they were positively correlated with UAE, SBP, DBP, LDL-C, and TC. We noted no significance correlated with course, TG, or HDL-C. Only TNF-α; was positively correlated with HbA1c. This study revealed the importance of these inflammatory cytokines in DN pathogenesis. Further studies are needed to fully establish the potential of these cytokines as additional biomarkers for the development of DN.
The relationship between support, commitment and intent to leave team: A social exchange perspective

Purpose – The purpose of this paper is to address and gain a more complete understanding of the effects on relationships between perceived team support (PTS), team commitment and intent to leave the team.Design/methodology/approach – Team commitment was examined as a mediator between perceived team support and intent to leave the team. To reach this objective, a survey on French white‐collar employee (n=355) was conducted. The procedure of Baron and Kenny was selected for the mediation test.Findings – The study provides several interesting data. First, data reveal two dimensions for PTS. The first one is labelled PTS toward work, the second one is labelled PTS toward well‐being. Second, while team commitment mediates the relationship between PTS toward work and intent to leave the team, team commitment does not mediate PTS toward well‐being and the intent to leave the team.Originality/value – The findings extend the understanding of how perceived team support and team commitment are related to intent to l.
Electrophysiological indexes of the detection and processing of auditory distractors

The occurrence of auditory changes in a stable environment may cause distraction. The pattern of this effect in the present thesis depended on the salience of the feature undergoing auditory change, the temporal distance and the spatial location between the task-irrelevant and task-relevant information. Moreover, the electrophysiological recordings helped to elucidate the cognitive processing underlying behavioural distraction. First, an early and automatic call for attention triggered by mismatch negativity (MMN) was generated by various types of changes, which corroborated its role as a genuine change detector. Second, the effective orienting of attention to the unexpected changes indexed by P3a appeared sensitive to the spatial location of the distractors, suggesting that the orienting of attention could be indeed an attentional spatial switch. And third, the cognitive processing of returning to primary task performance after a momentary distraction associated with the reorienting negativity (RON) component depended on the impaired stage of the ongoing target processing. Taken together, the results shed new light on the mental chronometry of auditory distraction.
Biochemical studies of the Saccharomyces cerevisiae Mph1 helicase on junction-containing DNA structures

Saccharomyces cerevisiae Mph1 is a 3–5′ DNA helicase, required for the maintenance of genome integrity. In order to understand the ATPase/helicase role of Mph1 in genome stability, we characterized its helicase activity with a variety of DNA substrates, focusing on its action on junction structures containing three or four DNA strands. Consistent with its 3′ to 5′ directionality, Mph1 displaced 3′-flap substrates in double-fixed or equilibrating flap substrates. Surprisingly, Mph1 displaced the 5′-flap strand more efficiently than the 3′ flap strand from double-flap substrates, which is not expected for a 3–5′ DNA helicase. For this to occur, Mph1 required a threshold size (>5 nt) of 5′ single-stranded DNA flap. Based on the unique substrate requirements of Mph1 defined in this study, we propose that the helicase/ATPase activity of Mph1 play roles in converting multiple-stranded DNA structures into structures cleavable by processing enzymes such as Fen1. We also found that the helicase activity of Mph1 was used to cause structural alterations required for restoration of replication forks stalled due to damaged template. The helicase properties of Mph1 reported here could explain how it resolves D-loop structure, and are in keeping with a model proposed for the error-free damage avoidance pathway.
Improving Acute Respiratory Infection Care Through Nurse Phone Care and Academic Detailing of Physicians

Introduction: To address unnecessary use of antibiotics for uncomplicated acute respiratory infection, we implemented a standardized care pathway composed of: (1) academic detailing of primary care providers, and (2) telephonic care from nurses. Methods: To evaluate the intervention, we performed a retrospective time series study and cost analysis at a primary care provider network in the Pacific Northwest with 118 providers at seven sites. The main outcomes were: (1) antibiotic rate, (2) provider visits avoided, and (3) cost savings from the payer and health care system perspectives. Data were collected for January 2, 2010 to November 30, 2013, with the interventions occurring on March 1, 2012. Results: There were 54,283 acute upper respiratory infection visits (34,678 [64%] female; average age, 52.1 years). After the intervention, nurse phone consultation involved 13.8% (3,289 of 23,769) of care episodes. The intervention was associated with a 16.5% absolute decrease in antibiotic rate (95% CI, −0.205 to −0.125; P < .001), after adjustment. Post intervention, 1983 of 23,769 (8.3%) episodes did not require any provider visit (1,133 per year). Single institution cost savings to payers exceeded $175,000. Conclusions: Implementation of nurse phone care and provider academic detailing was associated with lower inappropriate antibiotic usage and fewer unnecessary provider visits.
Prospective teachers’ ability to pose word problems

The purpose of this study was to assess difference in prospective teachers’ ability to pose word problems for mathematical expressions involving division before and after an instruction intervention. After the initial assessment of participants’ ability to pose word problems for division expressions, the researcher introduced an alternative model i.e. rate or ratio to represent division involving whole numbers. After the intervention it was assessed whether the model helped the prospective teachers develop word problems for division of fractions. The findings revealed that the prospective teachers successfully posed word problems for division of whole numbers based on intuitive model of fair sharing and to some extent they used repeated subtraction model but failed to represent division of fractions. A considerable improvement was observed in participants’ performance to pose word problems for division of fractions after going through instruction intervention. However the problems, which the prospective teachers posed, were, to a large extent, similar to the word problems, which the researcher used in the instruction.
Fibromyalgia: antecedent life events, disability, and causal attribution

This study aimed to evaluate the relation of disability and physical and mental health status with potentially traumatic life events (PTLE) before the onset of fibromyalgia in women diagnosed with this syndrome. We also investigated causal attribution of fibromyalgia to a triggering event, physical or psychological in nature, and its relation with the health measures and the adverse life events. The impact of fibromyalgia, physical and mental health status, pain, PTLE in childhood and not in childhood, and causal attribution were assessed in a sample of 50 women with fibromyalgia, aged 25–70 (M = 46.96; SD = 10.96). There were no statistically significant relations between the health measures (disability, physical and mental health, and pain) and the PTLE. The predominant attribution was to a physical event. There were no significant differences neither in the health measures across causal attribution status (Pillai’s Trace = 0.193; F(8,90) = 1.200; p = . 308; η 2 par = . 096) nor in the PTLE not in childhood (F(2,47) = 1.063; p = . 354; η 2 par = . 043). There were significant differences across causal attribution status in the PTLE in childhood (F(2,47) = 3.590; p = . 035; η 2 par = . 133), specifically between the group that made a psychological attribution and the group that made no attribution (C.I. 95%) 0.1805; 14.0468; (p = .043), with the former having a higher score of PTLE in childhood. The results raise questions about the importance of psychological aspects in the appraisal of the adverse events and its possible relation to the psychological functioning in women with fibromyalgia.
Reactive path deformation for nonholonomic mobile robots

This paper presents a novel and generic approach of path optimization for nonholonomic systems. The approach is applied to the problem of reactive navigation for nonholonomic mobile robots in highly cluttered environments. This is a collision-free initial path being given for a robot, and obstacles detected while following this path can make it in collision. The current path is iteratively deformed in order to get away from obstacles and satisfy the nonholonomic constraints. The core idea of the approach is to perturb the input functions of the system along the current path in order to modify this path, making an optimization criterion decrease.