Miracle-dz/UniFAR-FTUs huggingface dataset:
Generalized Information Equilibrium Approaches to EEG Sleep Stage Discrimination

Recent advances in neuroscience have raised the hypothesis that the underlying pattern of neuronal activation which results in electroencephalography (EEG) signals is via power-law distributed neuronal avalanches, while EEG signals are nonstationary. Therefore, spectral analysis of EEG may miss many properties inherent in such signals. A complete understanding of such dynamical systems requires knowledge of the underlying nonequilibrium thermodynamics. In recent work by Fielitz and Borchardt (2011, 2014), the concept of information equilibrium (IE) in information transfer processes has successfully characterized many different systems far from thermodynamic equilibrium. We utilized a publicly available database of polysomnogram EEG data from fourteen subjects with eight different one-minute tracings of sleep stage 2 and waking and an overlapping set of eleven subjects with eight different one-minute tracings of sleep stage 3. We applied principles of IE to model EEG as a system that transfers (equilibrates) information from the time domain to scalp-recorded voltages. We find that waking consciousness is readily distinguished from sleep stages 2 and 3 by several differences in mean information transfer constants. Principles of IE applied to EEG may therefore prove to be useful in the study of changes in brain function more generally.
Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients

Hyperhomocysteinemia in breast cancer (BC) patients can be a risk factor for thromboembolic events. This study aimed to evaluate homocysteine and its cofators (folic acid and vitamin B12) concentrations and platelet count at diagnosis of BC, 3 and 6 months after the beginning of chemotherapy treatment and to correlate them with clinical data.
A General Theory of Additive State Space Abstractions

Informally, a set of abstractions of a state space S is additive if the distance between any two states in S is always greater than or equal to the sum of the corresponding distances in the abstract spaces. The first known additive abstractions, called disjoint pattern databases, were experimentally demonstrated to produce state of the art performance on certain state spaces. However, previous applications were restricted to state spaces with special properties, which precludes disjoint pattern databases from being defined for several commonly used testbeds, such as Rubik's Cube, TopSpin and the Pancake puzzle. In this paper we give a general definition of additive abstractions that can be applied to any state space and prove that heuristics based on additive abstractions are consistent as well as admissible. We use this new definition to create additive abstractions for these testbeds and show experimentally that well chosen additive abstractions can reduce search time substantially for the (18,4)-TopSpin puzzle and by three orders of magnitude over state of the art methods for the 17-Pancake puzzle. We also derive a way of testing if the heuristic value returned by additive abstractions is provably too low and show that the use of this test can reduce search time for the 15-puzzle and TopSpin by roughly a factor of two.
Effect of xylitol, sodium fluoride and triclosan containing mouth rinse on Streptococcus mutans

Introduction: Prevention of dental caries is one of the main strategies in contemporary pediatric dental practice. Mouth rinses are widely used as an adjunct to maintain oral hygiene. It is important for these products to be effective and safe for regular use in children. Objective: The aim of the study was to investigate the efficacy of a newly introduced xylitol, sodium fluoride and triclosan containing mouth rinse in reducing levels of plaque Streptococcus mutans and to compare it with that of a 0.12% chlorhexidine mouth rinse. Materials and Methods: Thirty children were randomly divided into two groups of 15 children each. Group I (study group) was given a mouth rinse containing xylitol (5%), sodium fluoride (0.05%) and triclosan (0.03%) and Group II (control group) was given a chlorhexidine (0.12%) mouth rinse. Both mouth rinses were alcohol free. Mouth rinsing was carried out twice daily, half an hour after breakfast and half an hour following dinner, for a period of 21 days under the supervision of the investigator. Results: In both groups, there was a significant reduction in the mean S. mutans count at the end of 21 days (P < 0.001). No significant difference was observed between the two mouth rinses. Conclusion: The use of a low fluoride–xylitol based mouth rinse appears to be a suitable choice for regular use in children.
Effect of surface stiffness on the neural control of stretch‐shortening cycle movements

It is accepted that leg stiffness (Kleg) increases when surface stiffness decreases, and vice versa. However, little is known how the central nervous system fulfils this task. To understand the effect of surface stiffness on the neural control of stretch‐shortening cycle movements, this study aimed to compare modulation of spinal and corticospinal excitability at distinct phases after ground contact during two‐legged hopping when changing from solid to elastic ground.
Effects of whole-lake manipulations of nutrient loading and food web structure on planktonic respiration

We assessed planktonic respiration in whole-lake manipulations of nutrient loading and food web structure in three manipulated and one unmanipulated lake over 7 years. The manipulations created strong contrasts in zooplankton body size across a series of nutrient loads. Large-bodied zooplankton were suppressed by planktivorous fish in one lake, while in the other two manipulated lakes, large-bodied zooplankton dominated community biomass. Nutrients were added as inorganic N and P. Nutrient loads ranged from background to conditions resembling eutrophic lakes. Planktonic respiration was measured weekly in each lake by dark bottle oxygen consumption. Respiration was low when lakes were not fertilized (average 8.5 mmol O2·L -1 ·day -1 ) and was correlated with differences in dissolved organic carbon among the lakes. Respiration increased with nutrient addition to a mean range of 12-25 mmol O2·L -1 ·day -1 ; however, respiration differed among lakes at the same nutrient loading. Further, respiration was independent of dis - solved organic carbon in the fertilized lakes. Differences in the intensity of zooplankton grazing as determined by food web structure strongly regulated primary and bacterial production across the range of nutrient loads. Consequently, res - piration was positively related to primary production, phytoplankton biomass, and bacterial production and inversely re - lated to the average size of crustacean zooplankton.
Fluid homeostasis in the neonate

The physiology of the neonate is ideally suited to the transition to extrauterine life followed by a period of rapid growth and development. Intravenous fluids and electrolytes should be prescribed with care in the neonate. Sodium and water requirements in the first few days of life are low and should be increased after the postnatal diuresis. Expansion of the extracellular fluid volume prior to the postnatal diuresis is associated with poor outcomes, particularly in preterm infants. Newborn infants are prone to hypoglycemia and require a source of intravenous glucose if enteral feeds are withheld. Anemia is common, and untreated is associated with poor outcomes. Liberal versus restrictive transfusion practices are controversial, but liberal transfusion practices (accompanied by measures to minimize donor exposure) may be associated with improved long‐term outcomes. Intravenous crystalloids are as effective as albumin to treat hypotension, and semi‐synthetic colloids cannot be recommended at this time. Inotropes should be used to treat hypotension unresponsive to intravenous fluid, ideally guided by assessment of perfusion rather than blood pressure alone. Noninvasive methods of assessing cardiac output have been validated in neonates. More studies are required to guide fluid management in neonates, particularly in those with sepsis or undergoing surgery. A balanced salt solution such as Hartmann's or Plasmalyte should be used to replace losses during surgery (and blood or coagulation factors as indicated). Excessive fluid administration during surgery should be avoided.
Fasting and Glucose Effects on Pituitary Leptin Expression

Leptin, a potent anorexigenic hormone, is found in the anterior pituitary (AP). The aim of this study was to determine whether and how pituitary leptin–bearing cells are regulated by nutritional status. Male rats showed 64% reductions in pituitary leptin mRNA 24 hr after fasting, accompanied by significant (30–50%) reductions in growth hormone (GH), prolactin, and luteinizing hormone (LH), and 70–80% reductions in target cells for gonadotropin-releasing hormone or growth hormone-releasing hormone. There was a 2-fold increase in corticotropes. Subsets (22%) of pituitary cells coexpressed leptin and GH, and <5% coexpressed leptin and LH, prolactin, thyroid-stimulating hormone, or adrenocortico-tropic hormone. Fasting resulted in significant (55–75%) losses in cells with leptin proteins or mRNA, and GH or LH. To determine whether restoration of serum glucose could rescue leptin, LH, and GH, additional fasted rats were given 10% glucose water for 24 hr. Restoring serum glucose in fasted rats resulted in pituitary cell populations with normal levels of leptin and GH and LH cells. Similarly, LH and GH cells were restored in vitro after populations from fasted rats were treated for as little as 1 hr in 10–100 pg/ml leptin. These correlative changes in pituitary leptin, LH, and GH, coupled with leptin's rapid restoration of GH and LH in vitro, suggest that pituitary leptin may signal nutritional changes. Collectively, the findings suggest that pituitary leptin expression could be coupled to glucose sensors like glucokinase to facilitate rapid responses by the neuroendocrine system to nutritional cues. (J Histochem Cytochem 55: 1059–1073, 2007)
A security policy model for clinical information systems

The protection of personal health information has become a live issue in a number of countries, including the USA, Canada, Britain and Germany. The debate has shown that there is widespread confusion about what should be protected, and why. Designers of military and banking systems can refer to Bell & LaPadula (1973) and Clark & Wilson (1987) respectively, but there is no comparable security policy model that spells out clear and concise access rules for clinical information systems. In this article, we present just such a model. It was commissioned by doctors and is driven by medical ethics; it is informed by the actual threats to privacy, and reflects current best clinical practice. Its effect is to restrict both the number of users who can access any record and the maximum number of records accessed by any user. This entails controlling information flows across rather than down and enforcing a strong notification property. We discuss its relationship with existing security policy models, and its possible use in other applications where information exposure must be localised; these range from private banking to the management of intelligence data.
Graphical passwords: Learning from the first twelve years

Starting around 1999, a great many graphical password schemes have been proposed as alternatives to text-based password authentication. We provide a comprehensive overview of published research in the area, covering both usability and security aspects as well as system evaluation. The article first catalogues existing approaches, highlighting novel features of selected schemes and identifying key usability or security advantages. We then review usability requirements for knowledge-based authentication as they apply to graphical passwords, identify security threats that such systems must address and review known attacks, discuss methodological issues related to empirical evaluation, and identify areas for further research and improved methodology.
Operator Object Function Guidance for a Real-Time Unmanned Vehicle Scheduling Algorithm

Abstract : Advances in autonomy have made it possible to invert the typical operator-to-unmanned-vehicle ratio so that a single operator can now control multiple heterogeneous unmanned vehicles. Algorithms used in unmanned-vehicle path planning and task allocation typically have an objective function that only takes into account variables initially identified by designers with set weightings. This can make the algorithm seemingly opaque to an operator and brittle under changing mission priorities. To address these issues, it is proposed that allowing operators to dynamically modify objective function weightings of an automated planner during a mission can have performance benefits. A multiple-unmanned-vehicle simulation test bed was modified so that operators could either choose one variable or choose any combination of equally weighted variables for the automated planner to use in evaluating mission plans. Results from a human-participant experiment showed that operators rated their performance and confidence highest when using the dynamic objective function with multiple objectives. Allowing operators to adjust multiple objectives resulted in enhanced situational awareness, increased spare mental capacity, fewer interventions to modify the objective function, and no significant differences in mission performance. Adding this form of flexibility and transparency to automation in future unmanned vehicle systems could improve performance, engender operator trust, and reduce errors.
Primary Myocardial Disease

THE TERM primary myocardial disease refers to a variety of cardiac enlargement which is of unknown cause and frequently leads to cardiac dilatation, congestive heart failure, and finally to death. There are a number of synonyms. The disorder is also called idiopathic myocardial hypertrophy,' myocardiopathy, cardiac hypertrophy of unknown cause, and, especially in Great Britain, cardiomyopathy. In some centers the term "myocardosis" is used, although myocardlosis includes, in addition to primary myocardial disease of unknown origin, certain specific etiologic diseases of the heart such as beriberi, amyloidosis, hemochromatosis, and von Gierke's disease.
Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis*

Objective:Whereas most septic patients have an underlying comorbidity, most animal models of sepsis use mice that were healthy before the onset of infection. Malignancy is the most common comorbidity associated with sepsis. The purpose of this study was to determine whether mice with cancer have a different response to sepsis than healthy animals. Design:Prospective, randomized controlled study. Setting:Animal laboratory in a university medical center. Subjects:C57Bl/6 mice. Interventions:Animals received a subcutaneous injection of either 250,000 cells of the transplantable pancreatic adenocarcinoma cell line Pan02 (cancer) or phosphate-buffered saline (healthy). Three weeks later, mice given Pan02 cells had reproducible, nonmetastatic tumors. Both groups of mice then underwent intratracheal injection of either Pseudomonas aeruginosa (septic) or 0.9% NaCl (sham). Animals were killed 24 hrs postoperatively or followed-up 7 days for survival. Measurements and Main Results:Mice with cancer and healthy mice appeared similar when subjected to sham operation, although cancer animals had lower levels of T- and B-lymphocyte apoptosis. Septic mice with cancer had increased mortality compared to previously healthy septic mice subjected to the identical injury (52% vs. 28%; p = .04). This was associated with increased bacteremia but no difference in local pulmonary infection. Septic mice with cancer also had increased intestinal epithelial apoptosis. Although sepsis induced an increase in T- and B-lymphocyte apoptosis in all animals, septic mice with cancer had decreased T- and B-lymphocyte apoptosis compared to previously healthy septic mice. Serum and pulmonary cytokines, lung histology, complete blood counts, and intestinal proliferation were similar between septic mice with cancer and previously healthy septic mice. Conclusions:When subjected to the same septic insult, mice with cancer have increased mortality compared to previously healthy animals. Decreased systemic bacterial clearance and alterations in intestinal epithelial and lymphocyte apoptosis may help explain this differential response.
Role of a Cytotoxic-T-Lymphocyte Epitope-Defined, Alternative gag Open Reading Frame in the Pathogenesis of a Murine Retrovirus-Induced Immunodeficiency Syndrome

ABSTRACT LP-BM5 murine leukemia virus-infected C57BL/6 mice develop profound immunodeficiency and B-cell lymphomas. The LP-BM5 complex contains a mixture of defective (BM5def) and replication-competent helper viruses among which BM5def is the primary causative agent of disease. The BM5def primary open reading frame (ORF1) encodes the single gag precursor protein (Pr60gag). Our lab has recently demonstrated that a novel immunodominant cytotoxic-T-lymphocyte (CTL) epitope (SYNTGRFPPL) is expressed from a +1-nucleotide translational open reading frame of BM5def during the course of normal retrovirus expression. The SYNTGRFPPL CTL epitope may be generated from either of two initiation methionines present, ORF2a or ORF2b, located downstream of the ORF1 initiation site. This study investigates the role(s) of the alternative ORF2-derived gag protein(s) of BM5def in viral pathogenesis. We have examined the disease-inducing capabilities of mutant viruses in which the translational potential of either the initiating ORF2a or ORF2b AUG has been disrupted. Although these mutated viruses are capable of wild-type ORF1 expression, they are unable to induce disease. Our data strongly suggest the existence of a novel ORF2 product(s) that is required for LP-BM5-induced pathogenesis and have potentially broad implications for other retroviral diseases.
Does mixed-species flocking influence how birds respond to a gradient of land-use intensity?

Conservation biology is increasingly concerned with preserving interactions among species such as mutualisms in landscapes facing anthropogenic change. We investigated how one kind of mutualism, mixed-species bird flocks, influences the way in which birds respond to different habitat types of varying land-use intensity. We use data from a well-replicated, large-scale study in Sri Lanka and the Western Ghats of India, in which flocks were observed inside forest reserves, in ‘buffer zones' of degraded forest or timber plantations, and in areas of intensive agriculture. We find flocks affected the responses of birds in three ways: (i) species with high propensity to flock were more sensitive to land use; (ii) different flock types, dominated by different flock leaders, varied in their sensitivity to land use and because following species have distinct preferences for leaders, this can have a cascading effect on followers' habitat selection; and (iii) those forest-interior species that remain outside of forests were found more inside flocks than would be expected by chance, as they may use flocks more in suboptimal habitat. We conclude that designing policies to protect flocks and their leading species may be an effective way to conserve multiple bird species in mixed forest and agricultural landscapes.
A Method to Compute Dimension of an Air Distribution Channel of a Pneumatic Cylinder

– Dimension of an air distribution channel of a pneumatic cylinder is an important factor in a manufacturing process for developing a basic standard for industrial production. The main challenge is how to formulate a computation of the dimension in the form of a simple equation that can serve as a useful guide for local industries. The aim of this research is to determine the dimension of the air distribution channel of a pneumatic cylinder. Load cells and fitting dimension variant can be attached at the end of piston road and in inlet/outlet port of pneumatic cylinder. Furthermore moving time of piston road and loads derived from control valve and sensor operated. A number of factors related to various operating and loading conditions need to be considered to obtain optimum performance of the pneumatic cylinder. The results show that the working pressure and intake diameter are directly proportional to the cylinder performance. Increasing load of the cylinder causes a reduction in the pressure. For any changes in the dimension of the air distribution channel, the operation pressure and the external load influence the air flow speed entering the cylinder and at the same time also affect piston speed. Thus, an effective mathematical expression for computing the dimension of the channel in the pneumatic cylinder has been developed for that can be used in a manufacturing process, thereby yielding a useful product for both consumers and industries.
Incident Surveillance in New Jersey Career and Technical Education Programs, 1999 to 2008

Through school-sponsored career and technical education programs in New Jersey, students work part-time during or after school in paid and unpaid structured learning experiences regulated by the New Jersey Department of Education. Schools submit information on “reportable incidents,” injury or illness resulting in physician treatment. Incidents including reported use of personal protective equipment (PPE) were assessed; 1,600 incident reports (1999 to 2008) were received. Attributes such as type and severity, body parts affected, and PPE use for incidents occurring at school among students grades 9 to 12 or labeled as “adults” during school hours (n = 285) were analyzed. Older teens incurred more injuries. PPE use was consistently low across age and gender. Students most frequently experienced knife injuries involving fingers and hands. Results identified potential injury determinants and training and intervention topics such as PPE, and support development of an enhanced reporting form.
Crossing the Organizational Species Barrier: How Venture Capital Practices Infiltrated the Information Technology Sector

We examine the contagion processes whereby practices originating in one organizational population spread into and diffuse within a second. We theorize that “endemic” innovations native to one population spread to other populations through two distinct forms of contagion. We test this argument by observing information technology firms’ adoption of corporate venture capital programs. Results suggest that geographic proximity triggers cross-population contagion, that within-population contagion arises from different causal mechanisms, and that firms maintaining close cross-population ties pay less attention to the actions taken and outcomes experienced by other firms within their own industry. Fueled by emerging technology and a robust economy, corporate equity investing in start-up ventures exploded in the 1990s. The decade’s last five years alone saw a 3,800 percent increase, as corporate venture capital investments grew from $172 million to $6.8 billion (Venture Economics, 2006). Corporations scrambled to establish venture capital programs, identify best practices, and take equity in young entrepreneurial ventures. Rene Savelsberg, head of Philips’s corporate venture capital arm, described his program’s genesis as follows: