Miracle-dz/UniFAR-FTUs huggingface dataset:
Presuppositions, provisos, and probability

Theories of presupposition in the tradition associated with Karttunen, Stalnaker and Heim relate presupposition satisfaction to the content of conversational participants’ epistemic states, usually modeled as sets of worlds. However, converging evidence from recent work on modality and from other areas of cognitive science suggests that epistemic states are better thought of as having the richer structure of probability distributions. I describe an account of semantic and pragmatic presupposition which combines core ideas from dynamic semantic treatments with a probabilistic model of information states and their dynamics in conversation, and argue that it predicts the core data of the proviso problem (Geurts 1996) without invoking ad hoc mechanisms as conditional strengthening accounts typically do. The frequently cited intuition that (ir)relevance is crucial follows without stipulation, and I present new cases which suggest that irrelevance is too weak to predict all cases of unconditional presuppositions, problematizing strengthening accounts which rely on it. The proposed theory is able to account for this new data and also for semi-conditional presuppositions, a sticking point for previous theories of presupposition projection. I argue that this perspective also gives us a reasonable line on several related issues, including the divergence between presupposed conditionals and conditional presuppositions, instances of the proviso problem in counterfactuals, and the contextual variation in the difficulty of accommodation. http://dx.doi. org/10.3765/sp.5. 2 BibTeX info
Piwi Is Required in Multiple Cell Types to Control Germline Stem Cell Lineage Development in the Drosophila Ovary

The piRNA pathway plays an important role in maintaining genome stability in the germ line by silencing transposable elements (TEs) from fly to mammals. As a highly conserved piRNA pathway component, Piwi is widely expressed in both germ cells and somatic cells in the Drosophila ovary and is required for piRNA production in both cell types. In addition to its known role in somatic cap cells to maintain germline stem cells (GSCs), this study has demonstrated that Piwi has novel functions in somatic cells and germ cells of the Drosophila ovary to promote germ cell differentiation. Piwi knockdown in escort cells causes a reduction in escort cell (EC) number and accumulation of undifferentiated germ cells, some of which show active BMP signaling, indicating that Piwi is required to maintain ECs and promote germ cell differentiation. Simultaneous knockdown of dpp, encoding a BMP, in ECs can partially rescue the germ cell differentiation defect, indicating that Piwi is required in ECs to repress dpp. Consistent with its key role in piRNA production, TE transcripts increase significantly and DNA damage is also elevated in the piwi knockdown somatic cells. Germ cell-specific knockdown of piwi surprisingly causes depletion of germ cells before adulthood, suggesting that Piwi might control primordial germ cell maintenance or GSC establishment. Finally, Piwi inactivation in the germ line of the adult ovary leads to gradual GSC loss and germ cell differentiation defects, indicating the intrinsic role of Piwi in adult GSC maintenance and differentiation. This study has revealed new germline requirement of Piwi in controlling GSC maintenance and lineage differentiation as well as its new somatic function in promoting germ cell differentiation. Therefore, Piwi is required in multiple cell types to control GSC lineage development in the Drosophila ovary.
Item and Associative Memory Decline in Healthy Aging

When considering age-related deficits in episodic memory, nearly countless factors ranging from individual differences to memory instructions to type of memory test used have been shown to influence age differences in behavior (for extensive reviews see Cabeza, Nyberg, & Park, 2005; Craik, Anderson, Kerr, & Li, 1995; Dixon, Small, MacDonald, & McArdle, 2012; Zacks, Hasher, & Li, 2000). The following review will focus on a handful of such factors that have been shown to influence behavior in item memory and associative memory, as well as those investigated using functional neuroimaging. Item and associative memory represent key areas of research within the context of memory and aging. The former refers to memory for an individual item or episode, whereas the latter refers to memory for the relationship between two or more items or
Cartesian Parallel Manipulator Modeling, Control and Simulation

Parallel manipulators are robotic devices that differ from the more traditional serial robotic manipulators by their kinematic structure. Parallel manipulators are composed of multiple closed kinematic loops. Typically, these kinematic loops are formed by two or more kinematic chains that connect a moving platform to a base, where one joint in the chain is actuated and the other joints are passive. This kinematic structure allows parallel manipulators to be driven by actuators positioned on or near the base of the manipulator. In contrast, serial manipulators do not have closed kinematic loops and are usually actuated at each joint along the serial linkage. Accordingly, the actuators that are located at each joint along the serial linkage can account for a significant portion of the loading experienced by the manipulator, whereas the links of a parallel manipulator generally need not carry the load of the actuators. This allows the parallel manipulator links to be made lighter than the links of an analogous serial manipulator. The most noticeable interesting features of parallel mechanisms being: • High payload capacity. • High throughput movements (high accelerations). • High mechanical rigidity. • Low moving mass. • Simple mechanical construction. • Actuators can be located on the base. However, the most noticeable disadvantages being: • They have smaller workspaces than serial manipulators of similar size. • Singularities within working volume. • High coupling between the moving kinematic chains.
A Linear Approximation to the chi^2 Kernel with Geometric Convergence

We propose a new analytical approximation to the $\chi^2$ kernel that converges geometrically. The analytical approximation is derived with elementary methods and adapts to the input distribution for optimal convergence rate. Experiments show the new approximation leads to improved performance in image classification and semantic segmentation tasks using a random Fourier feature approximation of the $\exp-\chi^2$ kernel. Besides, out-of-core principal component analysis (PCA) methods are introduced to reduce the dimensionality of the approximation and achieve better performance at the expense of only an additional constant factor to the time complexity. Moreover, when PCA is performed jointly on the training and unlabeled testing data, further performance improvements can be obtained. Experiments conducted on the PASCAL VOC 2010 segmentation and the ImageNet ILSVRC 2010 datasets show statistically significant improvements over alternative approximation methods.
Temptation and Subjective Feasibility

This paper develops a new model of menu choice induced by temptation. The presence of temptation creates a utility cost in that choices cannot be recovered by maximization of consumption utility. However, in our model the cost of temptation is borne through constraints on the DM’s choice domain as opposed to an explicit cost function. The idea is that, within menu, objects are grouped together by attribute and the DM is only able to select an attribute possessed by a target choice, as opposed to selecting the choice itself. For example, when the DM looks at a dinner menu he can partly control himself by looking at the low-calorie portion of the menu, but within this subset he might be drawn to the most tempting option. The main feature of our model is the manner in which choices are grouped by attributes, we refer to these as categories. Categories are subjective, so that the exercise of the paper is to show how these can be elicited and identified from choices over menus.
Real-time human detection using multi-resolution HOGs

² The paper presents human detection algorithm that works on a general indoor/outdoor and urban/natural user generated video. The algorithm is based on a new multi-resolution histogram of oriented gradients feature for region description. The feature extraction is performed in constant time. Using cascaded approach for the classification of features low processing time is achieved. The final detector is robust to compression artifacts, different lighting conditions and white balance correction.
Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion

Integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) mediates the transient adhesion of polymorphonuclear leukocytes (PMN) to surfaces coated with fibrinogen, C3bi, ICAM-1, and other ligands. Recent studies (Cai, T.- Q., and S.D. Wright 1995. J. Biol. Chem. 270:14358) suggest that adhesion may be favored by stimulus-dependent changes in the kinetics of ligand binding by CR3. Cell detachment, on the other hand, must occur by a different mechanism because binding kinetics cannot affect cell adhesion after binding of ligand has occurred. We have sought a mechanism that would reverse binding of ligand to CR3 and report here that lysates of PMN contain an endogenous ligand that binds CR3 and competes the binding of C3bi. Purification and sequence analysis identified the structurally homologous azurophilic granule proteins, elastase, protease 3, and azurocidin as candidates. Studies with purified elastase and azurocidin showed that each bound specifically to purified, immobilized CR3. Elastase may play a role in modulating integrin-mediated cell adhesion because it is expressed at the cell surface, and the expression level is inversely proportional to cell adhesivity. Furthermore, a monoclonal antibody against elastase prevented detachment of PMN from fibrinogen-coated surfaces and blocked chemotaxis, confirming a role for this protein in regulating integrin- mediated adhesion. These studies suggest a model for release of integrin-mediated cell adhesion in which endogenous ligands such as elastase may release adhesion by "'eluting" substrate-bound ligand. A role for the proteolytic activity of elastase appears likely but is not demonstrated in this study.
Pathology and pathogenesis of vascular cognitive impairment—a critical update

Vascular cognitive impairment (VCI) [vascular cognitive disorder (VCD), vascular dementia] describes a continuum of cognitive disorders ranging from mild cognitive impairment (MCI) to dementia, in which vascular brain injury involving regions important for memory, cognition and behavior plays an important role. Clinical diagnostic criteria show moderate sensitivity (ca 50%) and variable specificity (range 64–98%). In Western clinical series, VaD is suggested in 8–10% of cognitively impaired elderly subjects. Its prevalence in autopsy series varies from 0.03 to 58%, with means of 8 to 15% (in Japan 22–35%). Major types of sporadic VaD are multi-infarct encephalopathy, small vessel and strategic infarct type dementias, subcortical arteriosclerotic leukoencephalopathy (SAE) (Binswanger), multilacunar state, mixed cortico-subcortical type, granular cortical atrophy (rare), postischemic encephalopathy, and a mixture of cerebrovascular lesions (CVLs). They result from systemic, cardiac and local large or small vessel disease (SVD); their pathogenesis is multifactorial. Hereditary forms of VaD caused by gene mutations are rare. Cognitive decline is commonly associated with widespread small ischemic vascular lesions involving subcortical brain areas (basal ganglia and hemispheral white matter). The lesions affect neuronal networks involved in cognition, memory, and behavior (thalamo-cortical, striato-subfrontal, cortico-subcortical, limbic systems). CVLs often coexist with Alzheimer-type lesions and other pathologies; 25–80% of elderly demented show mixed pathologies. The lesion pattern of “pure” VaD differs from that in mixed dementia (AD + CVLs) suggesting different pathogenesis of both phenotypes. Minor CVLs, except for severe amyloid angiopathy, appear not essential for cognitive impairment in full-blown AD, while both mild AD-type pathology and SVD may interact synergistically in promoting dementia. However, in a large percentage of non-demented elderly individuals, both AD-related and vascular brain pathologies have been reported. Despite recent suggestions for staging and grading CVLs in specific brain areas, due to the high variability of CVLs associated with cognitive impairment, no validated neuropathological criteria are currently available for VaD and mixed dementia. Further clinico-pathological studies and harmonization of neuropathological procedures are needed to validate the diagnostic criteria for VaD and mixed dementia in order to clarify the impact of CVLs and other coexistent pathologies on cognitive impairment as a basis for further successful therapeutic options.
Seasonality of Asthma: A Retrospective Population Study

OBJECTIVES: Seasonal variations in asthma are widely recognized, with the highest incidence during September. This retrospective population study aimed to investigate whether this holds true in a large group of asthmatic children in primary care and to assess the impact of age, gender, urban/rural living, and population sector. METHODS: The key study outcomes were the diagnosis of asthma exacerbations and asthma medication prescriptions, recorded by family physicians during 2005 to 2009. These were analyzed by “week of diagnosis” in Clalit Health Services’ electronic medical record database. Regression models were built to assess relative strength of secular trends, seasonality, and age-group in explaining the incidence of asthma exacerbations. RESULTS: A total of 919 873 children aged 2 to 15 years were identified. Of these, 82 234 (8.9%) were asthmatic, 61.6% boys and 38.4% girls; 49.1% aged 2 to 5 years, 24.1% 6 to 9 years, and 26.8% 10 to 15 years. We observed a 2.01-fold increase in pediatric asthma exacerbations and 2.28-fold increase in prescriptions of asthma bronchodilator medications during September (weeks 37–39 vs weeks 34–36) compared with August. The association between the opening of school and the incidence of asthma-related visits to the primary care physician was greatest in children aged 2 to 5 years (odds ratio, 2.15) and 6 to 11 years (1.90-fold). Adolescents (age 12–15 years) had a lesser peak (1.81-fold). In late fall there was a second rise, lasting with fluctuations throughout winter, with a trough in summer. CONCLUSIONS: Returning to school after summer is strongly associated with an increased risk for asthma exacerbations and unscheduled visits to the primary care physician.
Organizational Market Information Processes: Cultural Antecedents and New Product Outcomes

Organizational research suggests that the way information is used is likely to be a function of the presence of organizational systems or processes, in addition to individual manager activities. The author suggests that firms vary their emphasis on certain organizational market information processes, such as information acquisition, information transmission, conceptual use of information, and instrumental use of information. The author argues that the emphasis is determined, in part, by the congruence, or fit, among an organization's cultural norms and values and theorizes that the presence of these organizational information processes affects new product outcomes. Survey results indicate that clans dominate the other cultures in predicting organizational market information processes, suggesting that information processes are fundamentally “people processes” that involve commitment and trust among organizational members. The results have important implications for balancing internal and external orientations within firms. The results also indicate that the information utilization processes, especially those that are conceptual in nature, are strong predictors of new product performance, timeliness, and creativity, indicating that competitive advantage is tied to information utilization activities in firms.
Physical science teachers' responses to curriculum challenges in South Africa - pedagogical content knowledge focused case studies

science concepts, like energy, atoms, orbital, electronegativity, oxidation etc. are only understood by their manifestations during use – they are inventions of the science community to serve particular purposes in the science domain, and therefore are fundamentally situated. It follows then, that learning and knowledge are situated, since the constituent parts of knowledge index the word. They suggest the use of knowledge as a tool which is determined by the community or culture using it, and hence activity, concept/tool and culture are interdependent. None of the three can be understood without the other two.
Impacts of Microbial Activity on the Optical and Copper-Binding Properties of Leaf-Litter Leachate

Dissolved organic matter (DOM) is a universal part of all aquatic systems that largely originates with the decay of plant and animal tissue. Its polyelectrolytic and heterogeneous characters make it an effective metal-complexing agent with highly diverse characteristics. Microbes utilize DOM as a source of nutrients and energy and their enzymatic activity may change its composition, thereby altering the bioavailability and toxicity of metals. This study investigated the impacts of microbial inoculation upon the optical and copper-binding properties of freshly produced leaf-litter leachate over 168 h. Copper speciation was measured using voltammetry, and using fluorescence quenching analysis of independent fluorophores determined using parallel factor analysis (PARAFAC). Two protein/polyphenol-like and two fulvic/humic-like components were detected. Thirty-five percent of total protein/polyphenol-like fluorescence was removed after 168-h of exposure to riverine microbes. The microbial humic-like and tryptophan-like PARAFAC components retained significantly different log K values after 168 h of incubation (p < 0.05), while their complexing capacities were similar. Using voltammetry, a sixfold increase in copper-complexing capacity (CC, from 130 to 770 μmol Cu g C−1) was observed over the exposure period, while the conditional binding constant (log K) decreased from 7.2 to 5.8. Overall binding parameters determined using voltammetry and fluorescence quenching were in agreement. However, the electrochemically based binding strength was significantly greater than that exhibited by any of the PARAFAC components, which may be due to the impact of non-fluorescent DOM, or differences in the concentration ranges of metals analyzed (i.e., different analytical windows). It was concluded that the microbial metabolization of maple leaf leachate has a significant impact upon DOM composition and its copper-binding characteristics.
Evolution of Mutating Software

We propose using random walks in software space as abstract formal models of biological evolution. The goal is to shed light on biological creativity using toy models of evolution that are simple enough to prove theorems about them. We consider two models: a single mutating piece of software, and a population of mutating software. The fitness function is taken from a well-known problem in computability theory that requires an unlimited amount of creativity, the Busy Beaver problem.
Mechanism of late gadolinium enhancement in patients with acute myocardial infarction.

PURPOSE To investigate the mechanism of late gadolinium enhancement in irreversibly damaged myocardium in patients with acute myocardial infarct by determining kinetics of Gd-DTPA over time. METHODS Twenty-nine patients (24 men; 64 +/- 9 years) with acute myocardial infarction were imaged with functional and gadolinium enhanced cardiovascular magnetic resonance (CMR) 18 minutes post 0.2 mmol/kg Gd-DTPA. T1 of blood, remote and enhanced myocardium, as well as microvascular obstruction (MVO) was determined before and 5-40 minutes post contrast injection (Look-Locker), and the partition coefficient (lambda) was calculated. RESULTS T1 and lambda were significantly different from 5-40 minutes post contrast in enhanced (lambda = 0.90 +/- 0.09, p < 0.001) compared to remote myocardium (lambda = 0.40 +/- 0.07). lambda achieved a steady state in remote but increased continuously in infarcted myocardium and to an even greater extent in MVO. T1 of enhanced myocardium was higher from 5-15 minutes, equal at 20 minutes and lower 25-40 minutes post contrast compared to blood, indicating a changing contrast between blood and late gadolinium enhancement over time. CONCLUSION Enhancement in patients with acute infarction is mainly due to an increased lambda, although reduced wash-in-wash-out adds to the effect. Differentiation between blood and enhanced myocardium may be difficult to achieve, if only little differences of T1 are available. Imaging at a later point will restore the contrast.
The Impact of Ownership Structure on Corporate Performance in Transitional Economies

The relationship between ownership structure and corporate performance might be remarkably strong and in formative within transition economies. In this research, we explore this relationship, referring to the example of the Republic of Serbia. For that purpose, appropriate linear models have been fitted to the panel dataset compiled from financial reports of 2101 non-financial companies actively operating during the period 2008-2013. The results indicate that, after controlling for size effect, companies characterised by state, dispersed or/and foreign ownership have significantly lower profitability in comparison to their counterparts. We would argue that an intensified agency problem and lack of entrepreneurial spirit might be the root of the profitability problem.
Why Neck Pain Patients Are Not Referred to Manual Therapy: A Qualitative Study among Dutch Primary Care Stakeholders

Background Treatment of neck pain with manual therapy demonstrated to be more effective and cost-effective than general practitioner (GP) care or physiotherapy in a high quality RCT in the Netherlands in 2002. However, referral to manual therapy for neck pain is still relatively low. This study aims to explore the barriers and facilitators affecting the implementation of manual therapy in neck pain management in primary care. Methods An explorative study was conducted comprising semi-structured interviews with GPs (n = 13), physiotherapists (n = 10), manual therapists (n = 7) and their patients with neck pain (n = 27), and three focus groups with additional stakeholders (n = 10–12 per group). A thematic analysis approach was used. Results Different barriers and facilitators for referral were found for patients, GPs and physiotherapists on the individual level, but also in the interaction between stakeholders and their context. Individual perceptions such as knowledge and beliefs about manual therapy for neck pain either impeded or facilitated referral. Fear for complications associated with cervical manipulation was an important barrier for patients as well as GPs. For GPs and physiotherapists it was important whether they perceived it was part of their professional role to refer for manual therapy. Existing relations formed referral behavior, and the trust in a particular practitioner was a recurrent theme among GPs and physiotherapist as well as patients. The contextual factor availability of manual therapy played a role for all stakeholders. Conclusions Barriers and facilitators were found especially in individual perceptions on manual therapy for neck pain (e.g. knowledge and beliefs), the interaction between stakeholders (e.g. collaboration and trust) and the organizational context. Implementation strategies that focus on these different aspects seem to be likely to optimize referral rates and the use of manual therapy in primary care management of neck pain.