Miracle-dz/UniFAR-FTUs huggingface dataset:
Gradual and stepwise changes in the membrane capacitance of rat peritoneal mast cells.

1. The membrane capacitance of mast cells was monitored under voltage clamp, using sinusoidal excitation and a lock‐in amplifier. 2. Degranulation was accompanied by stepwise capacitance increases that presumably represent the fusion of single secretory granules with the cell membrane. Besides capacitance steps, we also observed gradual changes in capacitance that occurred even in the absence of degranulation, were independent of the presence of nucleotides in the pipette, and were steeply dependent on cytoplasmic [Ca2+]. 3. Cytoplasmic Ca2+ at concentrations of 0.3‐3 microM stimulated a decline in capacitance, with a dose‐response curve suggesting control by the binding of Ca2+ to high‐affinity intracellular sites. When maximally activated, this mechanism could lead to a loss of about 6% of the cell membrane capacitance, at an average rate of 0.1‐0.2% s‐1. 4. At even higher cytoplasmic [Ca2+] (greater than 3 microM), the reverse effect was observed. The capacitance increased gradually by up to 40%, at an average rate of 0.4% s‐1. Evidently gradual changes in membrane capacitance can occur by two mechanisms, and both are influenced by cytoplasmic [Ca2+]. 5. Ca2+ frequently stimulated an inward current accompanied by an increase in membrane conductance. 6. The effects described above were observed also when only trace amounts of Ca2+ and chelator were added to the cytosol, and when increases in cytosolic [Ca2+] could have occurred only by endogenous mechanisms. It is suggested that these effects occur also in intact cells during the large [Ca2+] increases known to occur before and during degranulation.
Subthreshold PTSD in Primary Care: Prevalence, Psychiatric Disorders, Healthcare Use, and Functional Status

The purpose of this study is to determine the prevalence of subthreshold posttraumatic stress disorder (PTSD) and its association with specific traumas, other psychiatric diagnoses, healthcare use, and functional status among 669 veterans in four VA Medical Centers. A cross-sectional, epidemiological design incorporating self-report measures, structured interviews, and chart reviews was used to obtain relevant information for analyses. Comparisons across three trauma-exposed groups (PTSD, subthreshold PTSD, no PTSD) revealed that veterans in the subthreshold PTSD group did not use mental health services more often than those in the no PTSD group despite the presence of additional mental health diagnoses and worse functional status. These data indicate that clinicians may be overlooking a subset of individuals suffering from subsyndromal PTSD, suggesting the need to detect and serve these individuals better within healthcare settings.
Reflecting the World “Out There”: A Cross-Cultural Perspective on Worries, Values and Well-Being

The study deals with the interrelation of values, worries, and well-being. It assumes that values govern worries, a central source of well-/ill-being. Relying on Schwartz's value theory, the hypothesis is tested that people with self-transcendence values (universalism, benevolence) experience macrosocial worries, whereas people with self-enhancement values (power, achievement) experience personal/microsocial worries. Furthermore, the hypothesis is tested that personal/microsocial worries are related to poor mental health, that macrosocial worries are related to good mental health, and that no direct relation between values and mental health exists. Samples from Germany (formerly East/West), Nepal, and Fiji are included. Predictions are supported that values relate differentially to worries and that personal/microsocial worries are related negatively to well-being, whereas macrosocial worries are related positively. Additionally, concordance with modal values of one's cultural reference group influences th.
Better you than I: Perspectives and emotion simulation during narrative comprehension

Recent studies suggest that readers develop richer multidimensional situation models when they mentally participate as characters in narrative worlds. The present study tested this by examining whether readers differentially represent situational elements when they read narratives using the pronoun “you” or “I” to describe a protagonist, and whether the pronoun “you” would make readers more likely to react to the emotional valence of narratives, embodying the affective states of protagonists. Response times and error rates to comprehension questions demonstrated a richer representation of the spatial organisation of narrative worlds with the pronoun “you” relative to “I”. Further, readers were more emotionally reactive to valenced narrative events with the pronoun “you”. Results demonstrate that readers differentially represent narrative worlds as a function of perspective, developing richer spatial mental models of layouts and a greater internalisation of emotional events when directly addressed as a protagonist.
Pentameric viral ion channels : from structure to function

: A family of small polypeptides in many virus types associate to form oligomers and have channel activity. These proteins have been referred to as viroporins or virochannels and are increasingly recognized as important virulence factors and potential drug targets. In this review, we focus on two of the viroporins that have been studied in more detail from a structural and functional point of view. One is the 76-residue envelope (E) protein found in coronaviruses (CoVs) that causes the severe acute respiratory syndrome (SARS). The other is the 65-residue small hydrophobic (SH) protein found in a paramyxovirus, the respiratory syncytial virus (RSV). RSV SH and SARS-CoV E proteins are short polypeptides with a single transmembrane domain. In both cases, the presence of the viroporin has a protective effect on cells, preventing early apoptosis, but it leads to increased virulence in infected animal models. Both viroporins form homopentameric oligomers that show channel activity with no or low selectivity. The role of channel activity is still unclear, but associations have been made to facilitation of the egress of the virus by modification of the secretory pathway, and contributions to inflammation. SARS-CoV E protein has a cytoplasmically oriented C-terminus and a lumenal N-terminus, whereas the opposite orientation is found in RSV SH protein. Despite this opposite topology, nuclear magnetic resonance (NMR)-based structural models of these two channels show a similar champagne flute shape, with the wider opening facing the cytoplasmic side. Good channel inhibitors are lacking, but those found seem to have a preference for the narrow end of the channel. Availability of good inhibitors will help reveal the specific role of these channels in the life cycle of these viruses.
Assessing Study Approaches in Sweden

Research into how Swedish students learn has mainly been based on qualitative methods In this paper we report evidence of the appropriateness of a Sweden version of the Biggs Study Process Questionnaire for 149 Swedish students in education. The questionnaire's scales were moderately internally consistent and showed the expected underlying factor structure. Scores on the scales correlated as predicted with a measure of self-esteem. Possible uses of this questionnaire with Swedish students are discussed.
The contribution of implicit cognition to the Theory of Reasoned Action Model: a study of food preferences

Abstract Attitudes are at the heart of the Theory of Reasoned Action (TRA), but problems in defining and measuring attitudes have contributed to typically low ability to predict behaviour. This article investigates the impact of potential disjuncture between evaluations that an individual externally verbalises (explicit attitudes), and evaluations that are internally held and may exist outside of conscious awareness (implicit attitudes), on the predictive ability of TRA. We study consumers’ attitudes towards eating healthy food and subsequent behaviour in a context of socially consensual behaviour. An Implicit Association Test (IAT) is used to measure implicit attitudes, and these scores are contrasted with self-reported explicit attitude scores. Ninety one participants took part in the study. We found, surprisingly, that implicit attitude has no significant effect on behavioural intention. However, a disjuncture between an individual’s implicit and explicit attitudes, reflecting internal psychological conflict, affected behaviour.
Prognostic Value of ICH Score and ICH-GS Score in Chinese Intracerebral Hemorrhage Patients: Analysis From the China National Stroke Registry (CNSR)

Purpose No strongevidenceofefficacycurrently exists for different intracerebral hemorrhage (ICH) scoring system in predicting the prognosis of ICH in the Chinese population. This study aimed to test the accuracyof the ICH score and the ICH grading scale (ICH-GS) score in predicting the favorable prognosis in a large cohort of ICH patients in China. Methods This study was a multicenter, prospective cohort study. Patients diagnosed with ICH between September 2007 and August 2008 from the nationwide China National Stroke Registry (CNSR) databasewere screened andenrolled in this study. Demographics of the patients, treatments, mortalityas well as the clinic and radiologic findings of ICH were collected.AnICH score and anICH-GS score were evaluated for all the patients atadmission. Follow-ups were conducted by phone at 3, 6 and 12 months after ICH onset. The modified Rankin scale (mRS) score was used to evaluate favorable functional outcome and was obtained at hospital dischargeand duringthe 3-, 6- and 12-month follow-up visits. Results There were 410 (12.6%) in-hospitalmortalityout of a total of 3,255 ICH patients. Thevalues of the Area Under Curve (AUC)at discharge, 3-, 6- and 12-month follow-up for ICH score were 0.72, 0.76, 0.76 and 0.75, respectively; whilethe numbers for the ICH-GS score were 0.71, 0.77, 0.78 and 0.78, respectively. At 6-month and 12-month follow-up, the ICH-GS score presented a significant better value in predicting favorable prognosis than did the ICH score (P=0.0003 and <0.0001, respectively). Conclusion Both the ICH and ICH-GS scores were effective inaccurately predicting the favorable functional outcome of ICH in the Chinese population. For mid-term and long-term prediction, the ICH-GS score was superiorover the ICH score.
Learning the Number of Neurons in Deep Networks

Nowadays, the number of layers and of neurons in each layer of a deep network are typically set manually. While very deep and wide networks have proven effective in general, they come at a high memory and computation cost, thus making them impractical for constrained platforms. These networks, however, are known to have many redundant parameters, and could thus, in principle, be replaced by more compact architectures. In this paper, we introduce an approach to automatically determining the number of neurons in each layer of a deep network during learning. To this end, we propose to make use of a group sparsity regularizer on the parameters of the network, where each group is defined to act on a single neuron. Starting from an overcomplete network, we show that our approach can reduce the number of parameters by up to 80\% while retaining or even improving the network accuracy.
Construct Validation of the Oddi Continuing Learning Inventory

The purpose of this study was to estimate the construct validity of the 24-item Oddi Continuing Learning Inventory (OCLI) and provide direction for revision of the instrument. Total OCLI scores correlated at low levels with total scores on the Job Activity Survey (JAS), a self-report measure of nurses' on-the-job learning activities, and with subscales representing learning through the modes of Inquiry, Performance, and Self-instruction. OCLI scores were not correlated with a subscale measuring Group Instruction and with voluntary attendance at continuing education programs. Further research of the OCLI should be aimed at (a) refinement of items to reflect learning through various modes and (b) investigation of practicing professionals from a variety of disciplines, using different approaches for estimating its construct validity.
Markets as Cultures: An Ethnographic Approach

The approach to the markets as cultures supposes at least three fields of studies: constitutive rules and roles; local rationality; dynamics of authorities and changes. The paper deals with each of the fields. The methodological issues of the study the markets as cultures are discussed after that. The author supports his statement by giving examples of his own ethnographic studies of the stock exchange, bond market and futures markets on the Wall-street.
Cultural Diversity on Campus: a Look At Intercollegiate Football Coaches

Those who attempt to increase cultural diversity in social organizations need to consider perceptions of access or opportunity for prestigious and visible positions. This research investigated career option viability for the positions of college athletic director and football coach through the examination of social characteristics of persons holding these positions at a sample of NCAA Division I-A institutions. Eighty-eight of the 105 institutions contacted supplied a copy of their 1990 football media guide. From these media guides, data were compiled for athletic directors, head football coaches, and full time assistant football coaches. Results clearly show that blacks were underrepresented at the athletic director, head coach, coordinator, and assistant coach positions. Additional results examining centrality ofposition played and position coached suggest that racial discrimi nation is institutionalized. Consequently, the pattern is likely to continue in the absence Of meaningful interventions. These data indicate that career opportunity is restricted for blacks by institutionalized discrimination in intercollegiate sport.
Human Papillomavirus (HPV) Type 18 Induces Extended Growth in Primary Human Cervical, Tonsillar, or Foreskin Keratinocytes More Effectively than Other High-Risk Mucosal HPVs

ABSTRACT Mucosal high-risk (HR) human papillomaviruses (HPVs) that cause cervical and other anogenital cancers also are found in ∼25% of head and neck carcinomas (HNCs), especially those arising in the oropharynx and the tonsils. While many HR HPV types are common in anogenital cancer, over 90% of HPV-positive HNCs harbor HPV type 16 (HPV-16). Using a quantitative colony-forming assay, we compared the ability of full-length mucosal HPV genomes, i.e., the low-risk HPV-11 and HR HPV-16, -18, and -31, to persist in and alter the growth of primary human keratinocytes from the foreskin, cervix, and tonsils. The HR HPV types led to the formation of growing keratinocyte colonies in culture independent of the site of epithelial origin. However, HPV-18 induced colony growth in all keratinocytes >4-fold more effectively than HPV-16 or HPV-31 and >20-fold more efficiently than HPV-11 or controls. HPV-11-transfected or control colonies failed to expand beyond 32 to 36 population doublings postexplantation. In contrast, individual HR HPV-transfected clones exhibited no apparent slowdown of growth or “crisis,” and many maintained HPV plasmid persistence beyond 60 population doublings. Keratinocyte clones harboring extrachromosomal HR HPV genomes had shorter population doubling times and formed dysplastic stratified epithelia in organotypic raft cultures, mirroring the pathological features of higher-grade intraepithelial lesions, yet did not exhibit chromosomal instability. We conclude that, in culture, the HR HPV type, rather than the site of epithelial origin of the cells, determines the efficacy of inducing continued growth of individual keratinocytes, with HPV-18 being the most aggressive mucosal HR HPV type tested.
An Efficient State Estimation Algorithm Considering Zero Injection Constraints

Traditional state estimation methods employ large weights for zero injection pseudo-measurements, which may result in numerical instability. The normal equations with constraints will increase the order of the coefficient matrix, thus reducing the speed of the calculations. To improve computational performance, this paper presents a modified Newton method to deal with zero injection constraints. The decoupled form of the proposed technique-a modified fast decoupled state estimation method-is also given. The computational speed of the proposed modified Newton method is similar to that of conventional state estimations based on normal equations, since they use the same type of coefficient matrices. Furthermore, it offers the advantage that zero injection constraints can be strictly satisfied, and the numerical stability problem caused by large weights will no longer exist. Extensive numerical results from test systems and a real provincial system are included to verify the performance of the proposed procedure.
Rompiendo el Silencio: Meta-Analysis of the Effectiveness of Peer-Mediated Learning at Improving Language Outcomes for ELLs

This article reports the results of a meta-analysis of the effectiveness of peer-mediated learning for English language learners. Peer-mediated learning is presented as one pedagogical tool with promise for interrupting a legacy of structural and instructional silencing of culturally and linguistically diverse students. Oral language (n = 13) and written language (n = 28) outcomes were analyzed, and main effects analyses indicate that peer mediation is highly effective at promoting both oral (g = .578, p = .000) and written language (g = .486, p = .000). A number of moderator analyses were conducted, and study-quality variables were the most important moderators across outcome types. Importantly, qualitative analysis of moderator variables provides tentative evidence that peer-mediation was more effective the more that students' L1 was used for instruction, and ELLs performed better in unsegregated environments where they had both language support services and access to native-English-speaking peers.
FBG1 Is the Final Arbitrator of A1AT-Z Degradation

Alpha-1 antitrypsin deficiency is the leading cause of childhood liver failure and one of the most common lethal genetic diseases. The disease-causing mutant A1AT-Z fails to fold correctly and accumulates in the endoplasmic reticulum (ER) of the liver, resulting in hepatic fibrosis and hepatocellular carcinoma in a subset of patients. Furthermore, A1AT-Z sequestration in hepatocytes leads to a reduction in A1AT secretion into the serum, causing panacinar emphysema in adults. The purpose of this work was to elucidate the details by which A1AT-Z is degraded in hepatic cell lines. We identified the ubiquitin ligase FBG1, which has been previously shown to degrade proteins by both the ubiquitin proteasome pathway and autophagy, as being key to A1AT-Z degradation. Using chemical and genetic approaches we show that FBG1 degrades A1AT-Z through both the ubiquitin proteasome system and autophagy. Overexpression of FBG1 decreases the half-life of A1AT-Z and knocking down FBG1 in a hepatic cell line, and in mice results in an increase in ATAT. Finally, we show that FBG1 degrades A1AT-Z through a Beclin1-dependent arm of autophagy. In our model, FBG1 acts as a safety ubiquitin ligase, whose function is to re-ubiquitinate ER proteins that have previously undergone de-ubiquitination to ensure they are degraded.
Working Memory Limitation, Phonological Deficit, Sequential Disorder and Syntactic Impairment in a Child with a Severe Developmental Dyslexia

The paper presents a case study of a child with a severe dyslexia, and focuses on the relationships between syntactic impairment, verbal memory limitation, sequential disorder and phonological deficit in his performance. These failures interacted very closely in his profile. An interesting and critical feature in the child's linguistic performance was the similarity between the pattern of syntactic errors displayed by him in sentence repetition and his syntactic performance in narrative productions elicited by a picture book. Comparisons between tasks requiring different levels of syntactic complexity and involving different memory demands suggested that he had a phonological/sequential/working memory impairment and a syntactic disorder. The complex interaction between phonological, syntactic and working memory deficits resulted in a severe learning disorder. The case study also suggests difficulties in the acquisition and the use of abstract linguistic elements. © 1997 John Wiley & Sons, Ltd.
Concurrent and Predictive Validities of the Bayley Motor Scale and the Peabody Developmental Motor Scales

Concurrent and predictive validities of the Bayley Motor Scale and the Peabody Developmental Motor Scales were examined by administering both tests to 23 full-term and 21 healthy premature infants at 12, 15, and 18 months of age. For both groups, a correlation analysis of age-equivalent scores indicated Bayley scores had good to high correlation with Peabody gross motor scores (range, r = .78 to r = .96) and unacceptable correlation with Peabody fine motor scores (range, r = .20 to r = .57). When results were reported using standardized quotients, mean Bayley quotients for the full-term infant group were significantly higher than Peabody gross motor quotients. Prediction of motor development at 18 months of age was limited (range, r = .25 to r = .60), with the exception of Peabody fine motor scores for the premature infant group (r = .75). This study provides evidence of concurrent validity between Bayley motor and Peabody gross motor age-equivalent scores, and it suggests the need for further testing, using separate assessments of gross motor and fine motor ability, to determine motor development at later ages.
Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer's Disease in Carriers of the APOEε4 Allele

Oxidative stress plays an important part in amnestic mild cognitive impairment (aMCI), the prodromal phase of Alzheimer's disease (AD). Recent evidence shows that polymorphisms in the SOD2 gene affect the elimination of the reactive oxygen species (ROS) generated in mitochondria. The aim of this study was to determine whether the functional rs4880 SNP in the SOD2 gene is a risk factor associated with aMCI and sporadic AD. 216 subjects with aMCI, 355 with AD, and 245 controls have been studied. The SNP rs4880 of the SOD2 gene was genotyped by RT-PCR and the APOE genotype was determined by PCR and RFLPs. Different multinomial logistic regression models were used to determine the risk levels for aMCI and AD. Although the T allele of the SOD2 rs4880 SNP gene (rs4880-T) is not an independent risk for aMCI or AD, this allele increases the risk to aMCI patients carrying at least one APOEε4 allele. Moreover, rs4880-T allele and APOEε4 allele combination has been found to produce an increased risk for AD compared to aMCI reference patients. These results suggest that APOEε4 and rs4880-T genotype may be a risk for aMCI and a predictor of progression from aMCI to AD.