Miracle-dz/UniFAR-FTUs huggingface dataset:
Microstructural Study of Steel-Concrete Interface and Its Influence on Bond Strength of Reinforced Concrete

In this investigation, the variations in steel-concrete interface (SCI) properties, such as porous zone thickness and calcium hydroxide content around the reinforcing steel, were studied with respect to curing time. Three kinds of commercially used cements, ordinary portland cement (OPC), portland pozzolana cement (PPC), and portland slag cement (PSC), were used, and their significance regarding SCI properties was investigated. A reliable thresholding grayscale-based technique was used to determine the porous zone thickness at the SCI. The properties of SCI were found to be quite influenced by the curing period. The PSC concrete showed significant reduction in mean porous zone thickness at SCI compared with OPC and PPC concrete after 90 days of curing. The reduction in mean porous zone thickness can be considered one of the many influencing factors that resulted in increased ultimate bond strength at 90 days of curing. Also, the variation in calcium hydroxide content from the SCI toward the bulk concrete was examined with a scanning electron microscope empowered with energy-dispersive spectroscopy. The findings indicate a gradual decrease in calcium hydroxide content away from the steel surface toward the bulk concrete. The prolonged curing resulted in a slightly higher reduction of calcium hydroxide content around the SCI for PPC and PSC concrete because of the pozzolanic reactions. Higher reduction of calcium hydroxide content around the SCI for PPC and PSC concrete is predicted to be the reason for improved ultimate bond strength after prolonged curing.
Convergent evolution of SWS2 opsin facilitates adaptive radiation of threespine stickleback into different light environments

Repeated adaptation to a new environment often leads to convergent phenotypic changes whose underlying genetic mechanisms are rarely known. Here, we study adaptation of color vision in threespine stickleback during the repeated postglacial colonization of clearwater and blackwater lakes in the Haida Gwaii archipelago. We use whole genomes from 16 clearwater and 12 blackwater populations, and a selection experiment, in which stickleback were transplanted from a blackwater lake into an uninhabited clearwater pond and resampled after 19 y to test for selection on cone opsin genes. Patterns of haplotype homozygosity, genetic diversity, site frequency spectra, and allele-frequency change support a selective sweep centered on the adjacent blue- and red-light sensitive opsins SWS2 and LWS. The haplotype under selection carries seven amino acid changes in SWS2, including two changes known to cause a red-shift in light absorption, and is favored in blackwater lakes but disfavored in the clearwater habitat of the transplant population. Remarkably, the same red-shifting amino acid changes occurred after the duplication of SWS2 198 million years ago, in the ancestor of most spiny-rayed fish. Two distantly related fish species, bluefin killifish and black bream, express these old paralogs divergently in black- and clearwater habitats, while sticklebacks lost one paralog. Our study thus shows that convergent adaptation to the same environment can involve the same genetic changes on very different evolutionary time scales by reevolving lost mutations and reusing them repeatedly from standing genetic variation.
Barefoot running does not affect simple reaction time: an exploratory study

Background Converging evidence comparing barefoot (BF) and shod (SH) running highlights differences in foot-strike patterns and somatosensory feedback, among others. Anecdotal evidence from SH runners attempting BF running suggests a greater attentional demand may be experienced during BF running. However, little work to date has examined whether there is an attentional cost of BF versus SH running. Objective This exploratory study aimed to examine whether an acute bout of BF running would impact simple reaction time (SRT) compared to SH running, in a sample of runners naïve to BF running. Methods Eight male distance runners completed SRT testing during 10 min of BF or SH treadmill running at 70% maximal aerobic speed (17.9 ± 1.4 km h−1). To test SRT, participants were required to press a hand-held button in response to the flash of a light bulb placed in the center of their visual field. SRT was tested at 1-minute intervals during running. BF and SH conditions were completed in a pseudo-randomized and counterbalanced crossover fashion. SRT was defined as the time elapsed between the light bulb flash and the button press. SRT errors were also recorded and were defined as the number of trials in which a button press was not recorded in response to the light bulb flash. Results Overall, SRT later in the exercise bouts showed a statistically significant increase compared to earlier (p < 0.05). Statistically significant increases in SRT were present at 7 min versus 5 min (0.29 ± 0.02 s vs. 0.27 ± 0.02 s, p < 0.05) and at 9 min versus 2 min (0.29 ± 0.03 s vs. 0.27 ± 0.03 s, p < 0.05). However, BF running did not influence this increase in SRT (p > 0.05) or the number of SRT errors (17.6 ± 6.6 trials vs. 17.0 ± 13.0 trials, p > 0.05). Discussion In a sample of distance runners naïve to BF running, there was no statistically significant difference in SRT or SRT errors during acute bouts of BF and SH running. We interpret these results to mean that BF running does not have a greater attentional cost compared to SH running during a SRT task throughout treadmill running. Literature suggests that stride-to-stride gait modulation during running may occur predominately via mechanisms that preclude conscious perception, thus potentially attenuating effects of increased somatosensory feedback experienced during BF running. Future research should explore the present experimental paradigm in a larger sample using over-ground running trials, as well as employing different tests of attention.
Dairy product consumption and risk of colorectal cancer in an older mediterranean population at high cardiovascular risk

Prospective studies have reported an inverse association between the consumption of total dairy products and milk and the risk of colorectal cancer (CRC). Nonetheless, there is little and inconsistent evidence regarding subtypes of dairy product and CRC risk. We assessed the associations between the consumption of total dairy products, their different subtypes and CRC risk in older Mediterranean individuals at high cardiovascular risk. We analyzed data from 7,216 men and women (55–80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Individuals were recruited between 2003 and 2009 and followed up until December 2012. At baseline and yearly thereafter, consumption of total and specific dairy products was assessed using a validated 137‐item food‐frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC incidence were estimated for tertiles of mean consumption of dairy products during the follow‐up. During a median [interquartile range] follow‐up of 6.0 [4.4–7.3] years, we documented 101 incident CRC cases. In the multivariable‐adjusted models, HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme tertiles of total dairy product and low‐fat milk consumption were 0.55 (95% CI: 0.31–0.99; p‐trend = 0.037) and 0.54 (95% CI: 0.32–0.92; p‐trend = 0.022), respectively. No significant associations with other dairy products (whole‐fat and low‐fat dairy products; total, low‐fat and whole‐fat yogurt; cheese; total, low‐fat and whole‐fat milk; concentrated full‐fat dairy products, sugar‐enriched dairy products and fermented dairy products) were found. A high consumption of total dairy products and low‐fat milk was significantly associated with a reduced CRC risk.
Ultrafast Manipulation of Magnetic Order with Electrical Pulses

During the last 30 years spintronics has been a very rapidly expanding field leading to lots of new interesting physics and applications. As with most technology-oriented fields, spintronics strives to control devices with very low energy consumption and high speed. The combination of spin and electronics inherent to spintronics directly tackles energy efficiency, due to the non-volatility of magnetism. However, speed of operation of spintronic devices is still rather limited (~nanoseconds), due to slow magnetization precessional frequencies.Ultrafast magnetism (or opto-magnetism) is a relatively new field that has been very active in the last 20 years. The main idea is that intense femtosecond laser pulses can be used in order to manipulate the magnetization at very fast time-scales (~100 femtoseconds). However, the use of femtosecond lasers poses great application challenges such as diffraction limited optical spot sizes which hinders device density, and bulky and expensive integration of femtosecond lasers into devices.In this thesis, our efforts to combine ultrafast magnetism and spintronics are presented. First, we show that the magnetization of ferrimagnetic GdFeCo films can be switched by picosecond electronic heat current pulses. This result shows that a non-thermal distribution of electrons directly excited by laser is not necessary for inducing ultrafast magnetic dynamics.Then, we fabricate photoconductive switch devices on a LT-GaAs substrate, to generate picosecond electrical pulses. Intense electrical pulses with 10ps (FWHM) duration and peak current up to 3A can be generated and delivered into magnetic films. Distinct magnetic dynamics in CoPt films are found between direct optical heating and electrical heating.More importantly, by delivering picosecond electrical pulses into GdFeCo films, we are able to deterministically reverse the magnetization of GdFeCo within ~10ps. This is more than one order of magnitude faster than any other electrically controlled magnetic switching. Our results present a fundamentally new switching mechanism electrically, without requirement for any spin polarized current or spin transfer/orbit torques. Our discovery that ultrafast magnetization switching can be achieved with electrical pulses will launch a new frontier of spintronics science and herald a new generation of spintronic devices that operate at high speed with low energy consumption.At last, to push ultrafast spintronics to practical use, ultrafast switching of a ferromagnetic film is desired. By exploiting the exchange interaction between GdFeCo and ferromagnetic Co/Pt layer, we achieved ultrafast (sub 10ps) switching of ferromagnetic film with a single laser pulse. This result will open up the possibility to control ferromagnetic materials at ultrafast time scale, critical for practical applications.
Using Tobit Kalman ﬁltering in order to improve the motion recorded by Microsoft Kinect

In this paper, we analyze data from Microsoft Kinect v 2 camera using Kalman Tobit and Kalman ﬁlters so as to minimize noise. The data concern three-dimensional spatial coordinates recording movements of a persons’A joints, which are subject to measurement errors. The noise variances of the process and the measurements are estimated using the maximum likelihood function. In order to include into the model restrictive conditions based on anthropometric data (e.g. the distances between various joints) we apply the Tobit Kalman Filter. Additionally, restrictions for the joints displacements per fame based on real data can be used in order to get better results. Finally simulations of skeleton before and after using Kalman ﬁltering are presented.
There is more to mind reading than having theory of mind concepts: new directions in theory of mind research

For more than 30 years, researchers have focused on the important transition that children undergo between the ages of 3 and 5, when they start to solve mind-reading problems that require reasoning about complex mental states, such as beliefs. The main question for debate has been whether, during that transition, children acquire new concepts about how the mind works (i.e. a more sophisticated 'theory of mind') or whether their more general cognitive abilities improve and help them deal with the general task demands. Recently, researchers have started to explore mind-reading abilities in individuals outside of the classic 3-5 age span, showing early theory of mind abilities in ever-younger children and infants, but also far from flawless performance in adults. In this article, we show how the results of these two new lines of research converge on the idea that there is more to mind reading than having theory of mind concepts: there are various processes required to efficiently implement theory of mind concepts in our reasoning, and there may be, in fact, multiple mind-reading routes available. We then highlight the emergent new directions for future research. Copyright (C) 2010 John Wiley & Sons, Ltd.
Probable functions and remobilisation of calcium oxalates in Musa L.

The occurrence and distribution of calcium oxalate crystals were investigated in the young and ageing structures of Musa L. cultivars. The calcium oxalate crystals were tested histochemically and examined using light microscopy. The studies revealed the presence of varying forms of the crystals including intra-amylar, solitary and raphide bundles in the different tissues and organs. Remobilization and redistribution of the crystals were observed following senescence in all the cultivars investigated. The usefulness of these observations in understanding the functions and fate of calcium oxalate crystals in plants are highlighted.
Antibacterial Efficacy of Silver Nanoparticles on Endometritis Caused by Prevotella melaninogenica and Arcanobacterum pyogenes in Dairy Cattle

Bovine postpartum diseases remain one of the most significant and highly prevalent illnesses with negative effects on the productivity, survival, and welfare of dairy cows. Antibiotics are generally considered beneficial in the treatment of endometritis; however, frequent usage of each antibiotic drug is reason for the emergence of multidrug resistance (MDR) of the pathogenic microorganisms, representing a major impediment for the successful diagnosis and management of infectious diseases in both humans and animals. We synthesized silver nanoparticles (AgNPs) with an average size of 10 nm using the novel biomolecule apigenin as a reducing and stabilizing agent, and evaluated the efficacy of the AgNPs on the MDR pathogenic bacteria Prevotella melaninogenica and Arcanobacterium pyogenes isolated from uterine secretion samples. AgNPs inhibited cell viability and biofilm formation in a dose- and time-dependent manner. Moreover, the metabolic toxicity of the AgNPs was assessed through various cellular assays. The major toxic effect of cell death was caused by an increase in oxidative stress, as evidenced by the increased generation of reactive oxygen species (ROS), malondialdehyde, protein carbonyl content, and nitric oxide. The formation of ROS is considered to be the primary mechanism of bacterial death. Therefore, the biomolecule-mediated synthesis of AgNPs shows potential as an alternative antimicrobial therapy for bovine metritis and endometritis.
Voting with Their Feet? Access to Infrastructure and Migration in Nepal

Using bilateral migration flow data from the 2010 population census of Nepal, this paper provides evidence on the importance of public infrastructure and services in determining migration flows. The empirical specification, based on a generalized nested logit model, corrects for the non-random selection of migrants. The results show that migrants prefer areas that are nearer to paved roads and have better access to electricity. Apart from electricity's impact on income and through income on migration, the econometric results indicate that migrants attach substantial amenity value to access to electricity. These findings have important implications for the placement of basic infrastructure projects and the way benefits from these projects are evaluated.
The Zinc-Finger Thylakoid-Membrane Protein FIP Is Involved With Abiotic Stress Response in Arabidopsis thaliana

Many plant genes have their expression modulated by stress conditions. Here, we used Arabidopsis FtsH5 protease, which expression is regulated by light stress, as bait in a yeast two-hybrid screen to search for new proteins involved in the stress response. As a result, we found FIP (FtsH5 Interacting Protein), which possesses an amino proximal cleavable transit peptide, a hydrophobic membrane-anchoring region, and a carboxyl proximal C4-type zinc-finger domain. In vivo experiments using FIP fused to green fluorescent protein (GFP) showed a plastid localization. This finding was corroborated by chloroplast import assays that showed FIP inserted in the thylakoid membrane. FIP expression was down-regulated in plants exposed to high light intensity, oxidative, salt, and osmotic stresses, whereas mutant plants expressing low levels of FIP were more tolerant to these abiotic stresses. Our data shows a new thylakoid-membrane protein involved with abiotic stress response in Arabidopsis thaliana.
Reinforcement learning for automatic test case prioritization and selection in continuous integration

Testing in Continuous Integration (CI) involves test case prioritization, selection, and execution at each cycle. Selecting the most promising test cases to detect bugs is hard if there are uncertainties on the impact of committed code changes or, if traceability links between code and tests are not available. This paper introduces Retecs, a new method for automatically learning test case selection and prioritization in CI with the goal to minimize the round-trip time between code commits and developer feedback on failed test cases. The Retecs method uses reinforcement learning to select and prioritize test cases according to their duration, previous last execution and failure history. In a constantly changing environment, where new test cases are created and obsolete test cases are deleted, the Retecs method learns to prioritize error-prone test cases higher under guidance of a reward function and by observing previous CI cycles. By applying Retecs on data extracted from three industrial case studies, we show for the first time that reinforcement learning enables fruitful automatic adaptive test case selection and prioritization in CI and regression testing.
Priority Queuing Models for Hospital Intensive Care Units and the Impacts to Severe Case Patients

This paper examines several different queuing models for intensive care units (ICU) and the effects on wait times, utilization, return rates, mortalities, and number of patients served. Five separate intensive care units at an urban hospital are analyzed and distributions are fitted for arrivals and service durations. A system-based simulation model is built to capture all possible cases of patient flow after ICU admission. These include mortalities and returns before and after hospital exits. Patients are grouped into 9 different classes that are categorized by severity and length of stay (LOS). Each queuing model varies by the policies that are permitted and by the order the patients are admitted. The first set of models does not prioritize patients, but examines the advantages of smoothing the operating schedule for elective surgeries. The second set analyzes the differences between prioritizing admissions by expected LOS or patient severity. The last set permits early ICU discharges and conservative and aggressive bumping policies are contrasted. It was found that prioritizing patients by severity considerably reduced delays for critical cases, but also increased the average waiting time for all patients. Aggressive bumping significantly raised the return and mortality rates, but more conservative methods balance quality and efficiency with lowered wait times without serious consequences.
Determination and Quantification of the Vinblastine Content in Purple, Red, and White Catharanthus Roseus Leaves Using RP-HPLC Method

Purpose: To determine and quantify vinblastine in different varieties of Catharanthus roseus using reversed-phase HPLC method. Methods: The liquid chromatographic separation was performed using a reversed phase C18, Microsorb - MV column (250 mm x 4.6 mm, 5 µm) at room temperature and eluted with a mobile phase containing methanol – phosphate buffer (5 mM, pH 6.0) – acetonitrile with different proportion gradient elution at a flow rate of 2.0 mL min-1 and detection at 254 nm. Results: The HPLC method was utilized for the quantification of vinblastine in purple, red and white varieties of Catharanthus roseus leaves. The separation was achieved in less than 8 min. The peak confirmation was done based on the retention times and UV spectra of the reference substance. The method was validated with respect to linearity, precision, recovery, limit of detection and quantification. Results showed that the purple variety gives 1.2 and 1.5 times more vinblastine concentration compared to the white and pink varieties, respectively. Conclusion: The obtained results from different varieties are thus useful for the purpose of vinblastine production from Catharanthus roseus plant.
Human Milk Oligosaccharides and Associations With Immune-Mediated Disease and Infection in Childhood: A Systematic Review

Complex sugars found in breastmilk, human milk oligosaccharides (HMOs), may assist in early-life immune programming and prevention against infectious diseases. This study aimed to systematically review the associations between maternal levels of HMOs and development of immune-mediated or infectious diseases in the offspring. PubMed and EMBASE databases were searched (last search on 22 February 2018) according to a predetermined search strategy. Original studies published in English examining the effect of HMOs on immune-mediated and infectious disease were eligible for inclusion. Of 847 identified records, 10 articles from 6 original studies were included, with study quality ranging from low to high. Of three studies to examine allergic disease outcomes, one reported a protective effect against cow’s milk allergy (CMA) by 18 months of age associated with lower lacto-N-fucopentaose (LNFP) III concentrations (OR: 6.7, 95% CI 2.0–22). Another study found higher relative abundance of fucosyloligosaccharides was associated with reduced diarrhea incidence by 2 years, due to (i) stable toxin-E. coli infection (p = 0.04) and (ii) “all causes” (p = 0.042). Higher LNFP-II concentrations were associated with (i) reduced cases of gastroenteritis and respiratory tract infections at 6 weeks (p = 0.004, p = 0.010) and 12 weeks (p = 0.038, p = 0.038) and (ii) reduced HIV transmission (OR: 0.45; 95% CI: 0.21–0.97) and mortality risk among HIV-exposed, uninfected infants (HR: 0.33; 95% CI: 0.14–0.74) by 24 months. Due to heterogeneity of the outcomes reported, pooling of results was not possible. There was limited evidence that low concentrations of LNFP-III are associated with CMA and that higher fucosyloligosaccharide levels protect infants against infectious disease. Further research is needed.