Miracle-dz/UniFAR-FTUs huggingface dataset:
Informal eldercare and work-related strain.

OBJECTIVES In light of an aging workforce, reconciling informal eldercare and paid work becomes increasingly pertinent. This article investigates the association between informal eldercare and work-related strain and tests for both the "competing demands" and "expansion" hypotheses. METHOD The sample of 938 Austrian employees consisted of employees caring for older relatives and a control group of employees without eldercare obligations. We ran a Tobit regression model on work-related strain with different measures of informal eldercare as explanatory variables and controls for both personal and workplace characteristics. RESULTS Accounting for different characteristics of eldercare within one estimation model revealed that informal eldercare was associated with work-related strain in 2 ways, that is, it increased with both care hours and subjective care burden. However, after controlling for these burdensome attributes of eldercare, the carer status as such was found to be negatively associated with work-related strain. In addition and independently of care commitments, work-related factors, such as advanced skills and job motivation, reduced work-related strain. DISCUSSION This article lends support to both the "competing demands" and the "expansion" hypotheses. Commitment to eldercare can enhance work-related outcomes but entails work-related problems if care burden and time demands of eldercare are substantial. Thus, workers with eldercare responsibilities cannot be considered less productive from the outset. An individual assessment of their situation, considering the care and work setting, is required. Findings from this study support the design of workplace initiatives to uphold workers' productivity in general and bring specific attention to policies alleviating workers' eldercare burden.
Multi-level trophic cascades in a heavily exploited open marine ecosystem

Anthropogenic disturbances intertwined with climatic changes can have a large impact on the upper trophic levels of marine ecosystems, which may cascade down the food web. So far it has been difficult to demonstrate multi-level trophic cascades in pelagic marine environments. Using field data collected during a 33-year period, we show for the first time a four-level community-wide trophic cascade in the open Baltic Sea. The dramatic reduction of the cod (Gadus morhua) population directly affected its main prey, the zooplanktivorous sprat (Sprattus sprattus), and indirectly the summer biomass of zooplankton and phytoplankton (top-down processes). Bottom-up processes and climate–hydrological forces had a weaker influence on sprat and zooplankton, whereas phytoplankton variation was explained solely by top-down mechanisms. Our results suggest that in order to dampen the occasionally harmful algal blooms of the Baltic, effort should be addressed not only to control anthropogenic nutrient inputs but also to preserve structure and functioning of higher trophic levels.
MICROMEGAS chambers for hadronic calorimetry at a future linear collider

Prototypes of MICROMEGAS chambers, using bulk technology and analog readout, with 1 ? 1 cm2 readout segmentation have been built and tested. Measurements in Ar/iC4H10 (95/5) and Ar/CO2 (80/20) are reported. The dependency of the prototypes gas gain versus pressure, gas temperature and amplification gap thickness variations has been measured with an 55Fe source and a method for temperature and pressure correction of data is presented. A stack of four chambers has been tested in 200 GeV/c and 7 GeV/c muon and pion beams respectively. Measurements of response uniformity, detection efficiency and hit multiplicity are reported. A bulk MICROMEGAS prototype with embedded digital readout electronics has been assembled and tested. The chamber's layout and first results are presented.
Primary Afferent Terminals in Spinal Cord Express Presynaptic AMPA Receptors

Larger dorsal root ganglion neurons are stained by an antibody for the C terminus of glutamate receptor subunit 2 (GluR2) and GluR3 (GluR2/3) rather than by an antibody for GluR4. In dorsal roots, anti-GluR2/3 stains predominantly myelinated fibers; anti-GluR4 or anti-GluR2/4 stains predominantly unmyelinated fibers. In the dorsal horn, puncta immunopositive for synaptophysin and GluR2/3 are predominantly in laminas III and IV, whereas puncta immunopositive for synaptophysin and GluR4 or GluR2/4 are predominantly in laminas I and II. Puncta immunopositive for GluR2/3 costain with the B subunit of cholera toxin, whereas puncta immunopositive for GluR2/4 costain with isolectin B4 after injections of these tracers in the sciatic nerve. No puncta costain with calcitonin gene-related peptide and AMPA receptor subunits. Electron microscopy indicates that AMPA receptor-immunopositive terminals are more numerous than suggested by confocal microscopy. Of all synapses in which immunostaining is presynaptic, postsynaptic, or both, the percentage of presynaptic immunostain is ∼70% with anti-GluR4 or anti-GluR2/4 (in laminas I–III), 25–30% with anti-GluR2/3 (in laminas III and IV), and 5% with anti-GluR2 (in laminas I–III). Because of fixation constraints, the types of immunostained terminals could be identified only on the basis of morphological characteristics. Many terminals immunostained for GluR2/3, GluR4, or GluR2/4 have morphological features of endings of primary afferents. Terminals with morphological characteristics of presumed GABAergic terminals are also immunostained with anti-GluR2/4 and anti-GluR4 in laminas I and II and with anti-GluR2/3 in laminas III and IV. The conspicuous and selective expression of presynaptic AMPA receptor subunits may contribute to the characteristic physiological profile of different classes of primary afferents and suggests an important mechanism for the modulation of transmitter release by terminals of both myelinated and unmyelinated primary afferents.
Evolution of Cluster and Field Elliptical Galaxies at 0.2 < z < 0.6 in the CNOC Cluster Survey

Two-dimensional surface photometry has been done for 166 early-type galaxies (bulge/total luminosity B/T > 0.6) in three fields of the Canadian Network for Observational Cosmology (CNOC) cluster survey. These galaxies are either spectroscopically confirmed members of clusters at z = 0.23 (45 galaxies), 0.43 (22), and 0.55 (16) or field galaxies in the same redshift range. An additional 51 early-type galaxies in the rich cluster Abell 2256 at z = 0.06 were analyzed with the same technique. The resulting structural and surface brightness measurements show that, in the plane of absolute magnitude MAB(B) versus log Re (half-light radius), the locus of cluster elliptical galaxies shifts monotonically with redshift so that at redshifts of (0.23, 0.43, 0.55), galaxies of a given size are more luminous by -0.25 ± 0.10, -0.55 ± 0.12, and -0.74 ± 0.21 mag with respect to the same relation measured at z = 0.06 (adopting q0 = 0.5). There is no evidence that early-type galaxies in the field evolve differently from those in clusters, although we emphasize that our cluster sample is dominated by galaxies far from the dense cluster core. If dynamical processes do not substantially modify the size-luminosity relation for early-type galaxies over the observed redshift range, then these galaxies have undergone significant luminosity evolution over the past half of the age of the universe. The amount of brightening is consistent with passive evolution models of old, single-burst stellar populations.
AnimalTFDB: a comprehensive animal transcription factor database

Transcription factors (TFs) are proteins that bind to specific DNA sequences, thereby playing crucial roles in gene-expression regulation through controlling the transcription of genetic information from DNA to RNA. Transcription cofactors and chromatin remodeling factors are also essential in the gene transcriptional regulation. Identifying and annotating all the TFs are primary and crucial steps for illustrating their functions and understanding the transcriptional regulation. In this study, based on manual literature reviews, we collected and curated 72 TF families for animals, which is currently the most complete list of TF families in animals. Then, we systematically characterized all the TFs in 50 animal species and constructed a comprehensive animal TF database, AnimalTFDB. To better serve the community, we provided detailed annotations for each TF, including basic information, gene structure, functional domain, 3D structure hit, Gene Ontology, pathway, protein–protein interaction, paralogs, orthologs, potential TF-binding sites and targets. In addition, we collected and annotated transcription cofactors and chromatin remodeling factors. AnimalTFDB has a user-friendly web interface with multiple browse and search functions, as well as data downloading. It is freely available at http://www.bioguo. org/AnimalTFDB/.
Quantum trajectories and quantum measurement theory

Beyond their use as numerical tools, quantum trajectories can be ascribed a degree of reality in terms of quantum measurement theory. In fact, they arise naturally from considering continuous observation of a damped quantum system. A particularly useful form of quantum trajectories is as linear (but non-unitary) stochastic Schrodinger equations. In the limit where a strong local oscillator is used in the detection, and where the system is not driven, these quantum trajectories can be solved. This gives an alternative derivation of the probability distributions for completed homodyne and heterodyne detection schemes. It also allows the previously intractable problem of real-time adaptive measurements to be treated. The results for an analytically soluble example of adaptive phase measurements are presented, and future developments discussed.
Adolescent Overweight and Obesity: Links to Socioeconomic Status and Fruit and Vegetable Intakes

Whether adolescent overweight/obesity is linked to socioeconomic status (SES) and fruit and vegetable (F/V) intakes has not been confirmed. We aimed to determine whether there is an association between SES and adolescent overweight/obesity and to test the mediating effect of F/V intakes. This cross-sectional study included the data of 63,111 adolescents extracted from the 2013 Korea Youth Risk Behavior Web-based Survey. Overweight/obesity was defined as a body mass index ≥ 85th percentile, while F/V intakes were categorized as high (recommended levels: ≥1 fruit serving and ≥3 vegetable servings per day) versus low. Among girls, low SES (beta = 0.50, p < 0.001) and F/V intakes (beta = −0.17, p = 0.038) were both significantly associated with overweight/obesity; the former association was significantly mediated by F/V intakes (Sobel test: z = 2.00, p = 0.046). Among boys, neither SES nor F/V intakes was significantly associated with overweight/obesity. Adolescent overweight/obesity was significantly linked to low SES and F/V intakes among girls only; low SES indirectly increased the risk of overweight/obesity via low F/V intakes. Therefore, promoting F/V intakes for socially disadvantaged girls should be prioritized as a population-based strategy for preventing adolescent overweight/obesity in South Korea.
Alcohol consumption and mortality risks in the USA.

AIMS To estimate all-cause and cause-specific mortality risks by alcohol consumption level for the US population. METHODS The survival analysis of data from National Health Interview Survey participants from 1997 to 2004 who were followed for mortality through 2006. Hazard ratios (HRs) adjusted for available demographic and health characteristics were calculated by alcohol consumption level for all-cause mortality and for mortality from circulatory and external causes. Alcohol consumption levels were generally defined as 'never drinker' (<12 drinks in life), 'former drinker' (0 drinks during last year), 'infrequent drinker' (<12 drinks in any year), 'light drinker' (1 drink per drinking day), 'moderate drinker'(2 drinks) and 'heavy drinker' (3+ drinks). RESULTS Adjusted mortality hazards for lifetime infrequent drinkers were much lower than the hazards for never drinkers among women, so lifetime infrequent drinkers were used as the reference category in survival analysis to estimate the mortality effects of alcohol consumption. Estimated all-cause mortality HRs for moderate drinkers were generally somewhat lower when compared with infrequent drinkers [HR for male moderate drinkers = 0.87, 95% confidence interval (CI) = 0.75-1.01 and HR for female occasional moderate drinkers = 0.80, 95% CI = 0.69-0.93]. Former drinkers and regular heavy drinkers had higher mortality hazards among both men and women. CONCLUSION US light to moderate drinkers may have reduced mortality risks, but some portion of their previously observed lower mortality may be due to factors other than alcohol consumption such as medical care and social integration, particularly among women. Alcohol consumption among former and heavy drinkers appears to have increased their mortality risks.
Age-related thinning of Bowman's layer in the human cornea in vivo.

PURPOSE To determine the thickness of Bowman's layer (BL) in vivo in a healthy population and to determine its variation with age. METHODS Eighty-two subjects aged 15 to 88 years with clear, healthy corneas were examined bilaterally with laser scanning in vivo confocal microscopy (IVCM). Bowman's layer thickness was determined from IVCM images of anterior and posterior BL boundaries. For a given eye, BL thickness was averaged across four central locations by two independent observers. In addition, central corneal thickness was measured by time-domain optical coherence tomography. RESULTS A significant negative correlation of BL thickness with age was found in right eyes (Pearson r = -0.579, P < 0.0001) and in left eyes (r = -0.558, P < 0.0001). Linear regression analysis yielded a decline in BL thickness of 0.06 μm per year. In 41 older subjects (mean age, 64.4 years), BL thickness was significantly thinner (mean ± SD, 8.6 ± 1.7 μm in right eyes) than that in 41 younger subjects (mean age, 31.6 years) (mean ± SD, 10.7 ± 1.6 μm in right eyes) (P < 0.001). No correlation of corneal thickness with age or of BL thickness with corneal thickness was observed. Strong intereye correlations in BL thickness (r = 0.771, P < 0.0001) and corneal thickness (r = 0.969, P < 0.001) were found. CONCLUSIONS Bowman's layer thins with age in the normal cornea, losing one-third of its thickness between the ages of 20 and 80 years. In vivo measurement of BL thickness by IVCM could aid in clinical assessment and planned treatments of the anterior cornea.
Safety and persistence of the humoral and cellular immune responses induced by 2 doses of an AS03-adjuvanted A(H1N1)pdm09 pandemic influenza vaccine administered to infants, children and adolescents: Two open, uncontrolled studies

In children, 2 AS03-adjuvanted A(H1N1)pdm09 vaccine doses given 21 days apart were previously shown to induce a high humoral immune response and to have an acceptable safety profile up to 42 days following the first vaccination. Here, we analyzed the persistence data from 2 open-label studies, which assessed the safety, and humoral and cell-mediated immune responses induced by 2 doses of this vaccine. The first study was a phase II, randomized trial conducted in 104 children aged 6–35 months vaccinated with the A(H1N1)pdm09 vaccine containing 1.9 µg haemagglutinin antigen (HA) and AS03B (5.93 mg tocopherol) and the second study, a phase III, non-randomized trial conducted in 210 children and adolescents aged 3–17 years vaccinated with the A(H1N1)pdm09 vaccine containing 3.75 µg HA and AS03A (11.86 mg tocopherol). Approximately one year after the first dose, all children with available data were seropositive for haemagglutinin inhibition and neutralising antibody titres, but a decline in geometric mean antibody titres was noted. The vaccine induced a cell-mediated immune response in terms of antigen-specific CD4+ T-cells, which persisted up to one year post-vaccination. The vaccine did not raise any safety concern, though these trials were not designed to detect rare events. In conclusion, 2 doses of the AS03-adjuvanted A(H1N1)pdm09 vaccine at 2 different dosages had a clinically acceptable safety profile, and induced high and persistent humoral and cell-mediated immune responses in children aged 6–35 months and 3–17 years. These studies have been registered at www.clinicaltrials. gov NCT00971321 and NCT00964158.
An evidence-based approach to working-memory based training in secondary education to improve reasoning test achievements

Secondary school teachers regularly observe that adolescent students have insufficient reasoning skills to properly answer reasoning test questions. One potentially effective strategy is developing learning strategies based on working memory training. This thesis contributes to our knowledge and insight into effective working memory based strategies that improve reasoning skills in secondary education humanities curricula. It does so by evaluating the effectiveness of a combined WM-capacity and reasoning strategy training to acquire reasoning skills in order to improve academic achievement. This could provide the necessary tools for both teachers and students to improve school-test results in humanities courses. From this dissertation it can be concluded that a combined content-based working memory capacity and reasoning strategy training appears to be an effective instrument to enhance school-based reasoning achievement. Reasoning achievements in school-test results do not seem to be affected by motivation levels when students use the combined training method. Furthermore, the combined working memory capacity and reasoning strategy training does not appear to discriminate between low or high achieving students in terms of improvements on reasoning tests.
The effects of extrusion of wheat distillers dried grains with solubles with or without an enzyme cocktail on performance of turkey hen poults.

Two experiments were conducted to determine if extrusion (EX) or enzymes (E) could overcome the restrictions (e.g., high fiber) of feeding wheat distillers dried grain with solubles (wDDGS) and improve its nutritional value for feeding turkeys. Two starter diets with either 0 or 30% wDDGS were formulated to meet or exceed the nutrient requirements of the Hybrid Converter female turkeys. The 30% wDDGS diet was substituted with either non-extruded (EX-) or extruded (EX+) wDDGS to produce three basal diets [0% wDDGS (EX-) or 30% wDDGS (EX-/EX+)]. Diets were blended to obtain 15% wDDGS. In the respective treatments, only wDDGS was extruded (temperature; 118°C, retention; 15 sec, total moisture; 25% and pressure 33 bar). The respective experimental diets were supplemented with/without an enzyme cocktail (E; 0.5 g/kg). Test diets were fed from 7-21 d in a completely randomized design. In Experiment 1, a total of 210 turkey hen poults were fed diets containing 0, 15, or 30% wDDGS (EX-) with or without enzyme (E+/E-). Body weight (BW) and feed intake (FI) were significantly higher for 0% wDDGSE-. Nitrogen retention (NR) and apparent metabolizable energy (AME) for the 30% wDDGSE- was significantly higher than other treatments at 21 d. The results indicated significant main effects of E and an interaction between wDDGS level and E. In Experiment 2, 280 turkey hen poults were fed 8 diets [15/30% wDDGS (E+/E-), (EX-/EX+)]. The level of wDDGS had a significant effect on BW, FI and gain:feed; 15% inclusion was superior to 30%. There were significant 2- and 3-way interactions for AME and NR at 21 d due to differences in enzyme response with 15 or 30% wDDGS inclusion and/or extrusion of wDDGS. As high as 15% wDDGS can be incorporated in turkey hen diets. There were no beneficial effects of EX or E on poult performance.
Neural Correlation Is Stimulus Modulated by Feedforward Inhibitory Circuitry

Correlated variability of neural spiking activity has important consequences for signal processing. How incoming sensory signals shape correlations of population responses remains unclear. Cross-correlations between spiking of different neurons may be particularly consequential in sparsely firing neural populations such as those found in layer 2/3 of sensory cortex. In rat whisker barrel cortex, we found that pairs of excitatory layer 2/3 neurons exhibit similarly low levels of spike count correlation during both spontaneous and sensory-evoked states. The spontaneous activity of excitatory–inhibitory neuron pairs is positively correlated, while sensory stimuli actively decorrelate joint responses. Computational modeling shows how threshold nonlinearities and local inhibition form the basis of a general decorrelating mechanism. We show that inhibitory population activity maintains low correlations in excitatory populations, especially during periods of sensory-evoked coactivation. The role of feedforward inhibition has been previously described in the context of trial-averaged phenomena. Our findings reveal a novel role for inhibition to shape correlations of neural variability and thereby prevent excessive correlations in the face of feedforward sensory-evoked activation.
Comparison of Mercury Distribution Between Liver and Musc - A Biomonitoring of Fish from Lightly and Heavily Contaminated Localities

Tissue samples from 1,117 fish of 25 species were collected from 1991 through 1996 at 13 locations along the River Elbe. The principal indicator species were perch (Perca fluviatilis) (n=118), chub (Leuciscus cephalus L.) (n=113) and roach (Rutilus rutilus) (n=138). Mercury (Hg) concentrations in muscle and liver were determined by atomic absorption spectrometry. The liver/muscle index in three indicator species from heavily contaminated and lightly contaminated localities were significantly different. In fish from heavily contaminated localities, Hg was deposited preferentially in the liver (the depository for inorganic and organic forms of Hg), while in lightly contaminated areas, it was deposited preferentially in muscle.
Challenges of pain control and the role of the ambulatory pain specialist in the outpatient surgery setting

Ambulatory surgery is on the rise, with an unmet need for optimum pain control in ambulatory surgery centers worldwide. It is important that there is a proportionate increase in the availability of acute pain-management services to match the rapid rise of clinical patient load with pain issues in the ambulatory surgery setting. Focus on ambulatory pain control with its special challenges is vital to achieve optimum pain control and prevent morbidity and mortality. Management of perioperative pain in the ambulatory surgery setting is becoming increasingly complex, and requires the employment of a multimodal approach and interventions facilitated by ambulatory surgery pain specialists, which is a new concept. A focused ambulatory pain specialist on site at each ambulatory surgery center, in addition to providing safe anesthesia, could intervene early once problematic pain issues are recognized, thus preventing emergency room visits, as well as readmissions for uncontrolled pain. This paper reviews methods of acute-pain management in the ambulatory setting with risk stratification, the utilization of multimodal interventions, including pharmacological and nonpharmacological options, opioids, nonopioids, and various routes with the goal of preventing delayed discharge and unexpected hospital admissions after ambulatory surgery. Continued research and investigation in the area of pain management with outcome studies in acute surgically inflicted pain in patients with underlying chronic pain treated with opioids and the pattern and predictive factors for pain in the ambulatory surgical setting is needed.