Miracle-dz/UniFAR-FTUs huggingface dataset:
A Diffusion and Clustering-Based Approach for Finding Coherent Motions and Understanding Crowd Scenes

This paper addresses the problem of detecting coherent motions in crowd scenes and presents its two applications in crowd scene understanding: semantic region detection and recurrent activity mining. It processes input motion fields (e.g., optical flow fields) and produces a coherent motion field named thermal energy field. The thermal energy field is able to capture both motion correlation among particles and the motion trends of individual particles, which are helpful to discover coherency among them. We further introduce a two-step clustering process to construct stable semantic regions from the extracted time-varying coherent motions. These semantic regions can be used to recognize pre-defined activities in crowd scenes. Finally, we introduce a cluster-and-merge process, which automatically discovers recurrent activities in crowd scenes by clustering and merging the extracted coherent motions. Experiments on various videos demonstrate the effectiveness of our approach.
Opinions of Slovenian family physicians on medically unexplained symptoms: A qualitative study

Objectives To determine the views of Slovenian family physicians on medically unexplained symptoms (MUS) and learn more about potential types of treatment for such patients. Methods Five focus groups, comprising 24 family medicine physicians (FMPs) from two Slovenian University centres, were convened. Conversations were led towards the research objectives by professionally trained researchers and followed a preliminarily established protocol. Qualitative content analysis of audio and transcripts of the discussions was performed using ATLAS.ti software to establish categories (‘codes’) relevant to issues regarding MUS. Results Slovenian FMPs emphasized the importance of good communication and trust between physicians and patients with MUS. Systemic barriers to effective management of MUS arising from the Slovenian health system were highlighted. FMPs stressed the need for more education in the recognition and treatment of MUS in primary care. From the discussions, 64 codes comprising broader research fields of MUS were developed, then grouped into a further eight categories: communication; doctor–patient relationship; causes of MUS; patient characteristics; physician characteristics; courses of action so far; positive relationship with patients; proposals for treatment. Conclusions The results are valuable in terms of investigating the treatment of patients with MUS in Slovenia, thereby opening new avenues of research on the subject of MUS.
Seed‐Free Solid‐State Growth of Large Lead‐Free Piezoelectric Single Crystals: (Na1/2K1/2)NbO3

Large Na0.5K0. 5NbO3 (NKN) piezoelectric single crystals were obtained by seed-free solid-state crystal growth method, which is a traditional sintering grain growth process, with LiBiO3 used as a sintering aid. The largest dimension of the single crystals obtained was 11 mm × 9 mm × 3 mm. In addition to the LiBiO3 doping content, temperature, and time effect of the crystal growth process was systematically investigated and considered from the kinetics point of view. With the assistance of Avrami analysis, parameters relevant to the crystal growth process were determined. Laue diffraction and transmission electron microscopy suggested an orthorhombic symmetry for the single crystalline structure. Dielectric-frequency-temperature measurements revealed an orthorhombic-tetragonal and tetragonal-cubic phase transition at 155°C and 405°C, respectively, both of which are typical of first-order transitions, and have a well-defined thermal hysteresis. Rayleigh analysis was performed regarding to the extrinsic reversible and nonreversible piezoelectric properties, and the result suggested a dominant intrinsic reversible piezoelectric contribution of 91.5% under E0 = 1 kV/cm AC amplitude. Such a single crystal growth process route is low cost and a relative simple preparation process.
Predicting Student Performance using Advanced Learning Analytics

Educational Data Mining (EDM) and Learning Analytics (LA) research have emerged as interesting areas of research, which are unfolding useful knowledge from educational databases for many purposes such as predicting students' success. The ability to predict a student's performance can be beneficial for actions in modern educational systems. Existing methods have used features which are mostly related to academic performance, family income and family assets; while features belonging to family expenditures and students' personal information are usually ignored. In this paper, an effort is made to investigate aforementioned feature sets by collecting the scholarship holding students' data from different universities of Pakistan. Learning analytics, discriminative and generative classification models are applied to predict whether a student will be able to complete his degree or not. Experimental results show that proposed method significantly outperforms existing methods due to exploitation of family expenditures and students' personal information feature sets. Outcomes of this EDM/LA research can serve as policy improvement method in higher education.
Main principles of task distribution in multi-agent systems and defining basic parameters

The article describes the main principles for the distribution and control of tasks in multi-agent systems. To reduce the execution time of tasks, we consider the principles of task allocation and determined that the basic parameters must be defined depending on the computing units and the number of actions needed to achieve the goal. By defining the parameters of computing capacity of each unit of our agents, it is possible to determine their degree of possibility of task execution.
Mapping of antigenic domains of Sendai virus nucleocapsid protein expressed in Escherichia coli

Several nonoverlapping epitopes were mapped on the primary sequence of the Sendai virus NP protein. After a complete cDNA clone of the Sendai virus NP gene was expressed in Escherichia coli, deletion constructs were used to generate a series of overlapping NP fragments deleted at their C termini. Immunoblot analyses with 11 monoclonal antibodies identified four antigenic sites. All of these sites resided in the C-terminal half of NP and were also the only sites detected with a polyclonal serum. These findings confirm and extend the evidence that the C terminus of the NP protein represents the domain exposed on the surface of the nucleocapsid. One of the monoclonal antibodies reacted with a site, comprising only 6 amino acids, lying with a hinge between an alpha-helix and a beta-strand in the predicted secondary structure of NP. Since this antibody is a potent inhibitor of in vitro viral RNA synthesis (K. L. Deshpande and A. Portner, Virology 139:32-42, 1984), the epitope may be critical to the flexibility of the NP molecule that makes the RNA template accessible during RNA synthesis.
Aggregation and Resource Scheduling in Machine-Type Communication Networks: A Stochastic Geometry Approach

Data aggregation is a promising approach to enable massive machine-type communication. This paper focuses on the aggregation phase where a massive number of machine-type devices (MTDs) transmit to aggregators. By using non-orthogonal multiple access (NOMA) principles, we allow several MTDs to share the same orthogonal channel in our proposed hybrid access scheme. We develop an analytical framework based on stochastic geometry to investigate the system performance in terms of average success probability and average number of simultaneously served MTDs, under imperfect successive interference cancellation (SIC) at the aggregators, for two scheduling schemes: random resource scheduling and channel-aware resource scheduling (CRS). We identify the power constraints on the MTDs sharing the same channel to attain a fair coexistence with purely orthogonal multiple access (OMA) setups. Then, power control coefficients are found, so that these MTDs perform with similar reliability. We show that under high access demand, the hybrid scheme with CRS outperforms the OMA setup by simultaneously serving more MTDs with reduced power consumption.
The OST4 Gene of Saccharomyces cerevisiae Encodes an Unusually Small Protein Required for Normal Levels of Oligosaccharyltransferase Activity (*)

Sodium vanadate is an effective drug for the enrichment of yeast mutants defective in glycosylation reactions that are carried out in the Golgi complex(1). We have isolated vanadate-resistant, hygromycin B-sensitive mutants that act at very early steps of N-linked glycosylation, occurring in the endoplasmic reticulum. Here we describe the phenotypic characterization of ost4, a vanadate-resistant mutant that is defective in oligosaccharyltransferase (OTase) activity both in vivo and in vitro. The OST4 open reading frame is unusual in that it predicts a protein of only 36 amino acids. We demonstrate that the OST4 gene product is, in fact, an unusually small protein of approximately 3.6 kDa, predicted to lie almost entirely in the hydrophobic environment of the membrane. Strains carrying a disruption of the OST4 gene are viable but grow poorly at 25°C. The null mutant is inviable at 37°C, demonstrating that the OST4 gene product is essential for growth at high temperatures. Deletion of the OST4 gene greatly diminishes OTase activity but does not abolish it. These results suggest that the OST4 gene encodes a subunit or accessory component of OTase that is essential at high temperature.
Conserved Structural and Functional Control of N-Methyl-d-aspartate Receptor Gating by Transmembrane Domain M3*

The molecular events controlling glutamate receptor ion channel gating are complex. The movement of transmembrane domain M3 within N-methyl-d-aspartate (NMDA) receptor subunits has been suggested to be one structural determinant linking agonist binding to channel gating. Here we report that covalent modification of NR1-A652C or the analogous mutation in NR2A, -2B, -2C, or -2D by methanethiosulfonate ethylammonium (MT-SEA) occurs only in the presence of glutamate and glycine, and that modification potentiates recombinant NMDA receptor currents. The modified channels remain open even after removing glutamate and glycine from the external solution. The degree of potentiation depends on the identity of the NR2 subunit (NR2A < NR2B < NR2C,D) inversely correlating with previous measurements of channel open probability. MTSEA-induced modification of channels is associated with increased glutamate potency, increased mean single-channel open time, and slightly decreased channel conductance. Modified channels are insensitive to the competitive antagonists d-2-amino-5-phosphonovaleric acid (APV) and 7-Cl-kynurenic acid, as well as allosteric modulators of gating (extracellular protons and Zn2+). However, channels remain fully sensitive to Mg2+ blockade and partially sensitive to pore block by (+)MK-801, (-)MK-801, ketamine, memantine, amantadine, and dextrorphan. The partial sensitivity to (+)MK-801 may reflect its ability to stimulate agonist unbinding from MT-SEA-modified receptors. In summary, these data suggest that the SYTANLAAF motif within M3 is a conserved and critical determinant of channel gating in all NMDA receptors.
Pleistocene climate change and the formation of regional species pools

Despite the description of bioregions dates back from the origin of biogeography, the processes originating their associated species pools have been seldom studied. Ancient historical events are thought to play a fundamental role in configuring bioregions, but the effects of more recent events on these regional biotas are largely unknown. We use a network approach to identify regional and sub-regional faunas of European Carabus beetles, and analyse the effects of dispersal barriers, niche similarities and phylogenetic history on their configuration. We identify a transition zone matching the limit of the ice sheets at Last Glacial Maximum. While southern species pools are mostly separated by dispersal barriers, in the north species are mainly sorted by their environmental niches. Strikingly, most phylogenetic structuration of Carabus faunas occurred since the beginning of the Pleistocene. Our results show how extreme recent historical events –such as Pleistocene climate cooling, rather than just deep-time evolutionary processes, can profoundly modify the composition and structure of geographic species pools.
Faculteit Economie En Bedrijfskunde Tweekerkenstraat 2 B-9000 Gent Random Multiclass Classification: Generalizing Random Forests to Random Mnl and Random Nb Random Multiclass Classification: Generalizing Random Forests to Random Mnl and Random Nb

Random Forests (RF) is a successful classifier exhibiting performance comparable to Adaboost, but is more robust. The exploitation of two sources of randomness, random inputs (bagging) and random features, make RF accurate classifiers in several domains. We hypothesize that methods other than classification or regression trees could also benefit from injecting randomness. This paper generalizes the RF framework to other multiclass classification algorithms like the well-established MultiNomial Logit (MNL) and Naive Bayes (NB). We propose Random MNL (RMNL) as a new bagged classifier combining a forest of MNLs estimated with randomly selected features. Analogously, we introduce Random Naive Bayes (RNB). We benchmark the predictive performance of RF, RMNL and RNB against state-of-the-art SVM classifiers. RF, RMNL and RNB outperform SVM. Moreover, generalizing RF seems promising as reflected by the improved predictive performance of RMNL.
Increased Systolic and Diastolic Blood Pressure Is Associated With Altered Gut Microbiota Composition and Butyrate Production in Early Pregnancy

The risk of developing pregnancy-induced hypertension and preeclampsia is higher in obese pregnant women. In obesity, the composition of the gut microbiota is altered. Obesity is also associated with low-grade inflammation. Metabolites from the gut microbiota may contribute to both hypertension and inflammation. The aim of this study is to investigate whether the composition of the gut microbiota in overweight and obese pregnant women is associated with blood pressure and levels of plasminogen activator inhibitor-1. The composition of the gut microbiota was determined with 16S ribosomal RNA sequencing in 205 women at 16 weeks gestation from the SPRING study (the Study of Probiotics in Gestational Diabetes). Expression of butyrate-producing genes in the gut microbiota was assessed by real-time polymerase chain reaction. Plasminogen activator inhibitor-1 levels were measured in fasting serum of a subset of 70 women. Blood pressure was slightly but significantly higher in obese compared with overweight women. The abundance of the butyrate-producing genus Odoribacter was inversely correlated with systolic blood pressure. Butyrate production capacity was decreased, but plasminogen activator inhibitor-1 concentrations increased in obese pregnant women. Plasminogen activator inhibitor-1 levels were inversely correlated with expression of butyrate kinase and Odoribacter abundance. This study shows that in overweight and obese pregnant women at 16 weeks gestation, the abundance of butyrate-producing bacteria and butyrate production in the gut microbiota is significantly negatively associated with blood pressure and with plasminogen activator inhibitor-1 levels. Increasing butyrate-producing capacity may contribute to maintenance of normal blood pressure in obese pregnant women.
Psychoeducation for bipolar disorder

Bipolar disorder is a complex disorder of mood and behaviour that requires a multimodal treatment approach. In the past 10 years there has been growing interest in psychoeducational interventions delivered as adjuncts to conventional management. Several studies have tested the effectiveness of psychoeducational treatments delivered in a variety of formats. In this article we assess the evidence for the efficacy of these interventions and consider the likely future role of structured psychoeducational treatments in clinical practice.
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

The C-type lectin-like receptor CD161, which has recently been described to promote T cell expansion, is expressed on a discrete subset of human CD4 T cells. The function of such cells, however, has remained elusive. We now demonstrate that CD161+ CD4 T cells comprise a circulating and gut-resident T helper 17 (Th17) cell population. During Crohn's disease (CD), these CD161+ cells display an activated Th17 phenotype, as indicated by increased expression of interleukin (IL)-17, IL-22, and IL-23 receptor. CD161+ CD4 T cells from CD patients readily produce IL-17 and interferon γ upon stimulation with IL-23, whereas, in healthy subjects, priming by additional inflammatory stimuli such as IL-1β was required to enable IL-23–induced cytokine release. Circulating CD161+ Th17 cells are imprinted for gut homing, as indicated by high levels of CC chemokine receptor 6 and integrin β7 expression. Supporting their colitogenic phenotype, CD161+ Th17 cells were found in increased numbers in the inflammatory infiltrate of CD lesions and induced expression of inflammatory mediators by intestinal cells. Our data identify CD161+ CD4 T cells as a resting Th17 pool that can be activated by IL-23 and mediate destructive tissue inflammation.
Dissemination of Cronobacter spp. (Enterobacter sakazakii) in a Powdered Milk Protein Manufacturing Facility

ABSTRACT The microbial contamination of air filters and possible links to contaminated product in a powdered milk protein-processing facility were investigated. Over a 10-month period, seven air filters, the environment, and powdered product were analyzed for the presence of Cronobacter spp. The effects of air filter installation, maintenance, and subsequent dissemination of Cronobacter were investigated. A total of 30 isolates were characterized by pulsed-field gel electrophoresis (PFGE). PFGE revealed the presence of three clonal populations distributed throughout the manufacturing site. This study highlights the need for proper installation of air filters to limit the dissemination of microorganisms into processing sites.
LIGHT CONDUCTION CAPABILITY OF DIFFERENT LIGHT-TRANSMITTING FRC POSTS

Introduction: Application of light transmitting posts to restore greatly damaged endodontically treated teeth has been increased. It is suspected that light intensity decreases as it passes throughout different materials. This can reduce the degree of conversion required for adequate bond strength throughout the length of these posts. The objective of this study was to evaluate the amount of light intensity reduction after passing through different depths of FRC posts. Methods: Four groups of five extracted human central incisors were prepared to cement four types of FRC posts with Panavia F 2 resin cement. The apical end of the posts were exposed by sectioning with a diamond disk and then polished. The light intensity measurement was performed using a micro-voltmeter in 8 points or depths with 2mm intervals beginning from the apical depth of 16mm up to a coronal depth of 6mm. Two different output light intensities [HIP (High Intensity Program) and LOP (Low Intensity Program)] were evaluated. Results: Statistical analysis showed significant differences in light intensity at various depths between 6 and 16mm in all groups. These reductions were linear in all specimens; however, the rate of reduction was dissimilar among different FRC posts. HIP and LOP light exposure modes had not the same rate of light reduction. Conclusion: Light intensity decreased dramatically after passing through different depths of FRC posts. None of the posts had sufficient enough light transmission for satisfactory polymerization at the apical and middle levels.
Effects of Low versus High Glycemic Index Sugar-Sweetened Beverages on Postprandial Vasodilatation and Inactivity-Induced Impairment of Glucose Metabolism in Healthy Men

Intake of sugar-sweetened beverages (SSB) may contribute to cardiovascular risk. The aim of this study was to investigate whether functional sugars with low compared to high glycemic index (GI) have beneficial effects on arterial stiffness during a period of low-physical activity. In a controlled cross-over dietary intervention (55% CHO, 30% fat, 15% protein), 13 healthy men (age: 23.7 ± 2.2 years, body mass index: 23.6 ± 1.9 kg/m2) completed 2 × 1 week of low physical activity following 1 week of normal physical activity (2363 ± 900 vs. 11,375 ± 3124 steps/day). During inactive phases participants consumed either low-GI (isomaltulose) or high-GI SSB (maltodextrin-sucrose), providing 20% of energy requirements. Postprandial vasodilatation (augmentation index, AIx), insulin sensitivity (IS) and Glucagon-like-peptide 1 (GLP-1) responses were measured during a meal test before and after SSB-intervention. Compared to maltodextrin-sucrose-SSB, postprandial vasodilatation was prolonged (AIx after 120 min: 9.9% ± 4.3% vs. 11.4% ± 3.7%, p < 0.05) and GLP-1 secretion was higher with isomaltulose-SSB (total area under the GLP-1 curve (tAUCGLP)-1: 8.0 ± 4.4 vs. 5.4 ± 3.4 pM × 3 h; p < 0.05). One week of low-physical activity led to impaired IS that was attenuated with low-GI SSB consumption, but did not affect arterial stiffness (p > 0.05). Higher postprandial GLP-1 secretion after intake of low compared to high-GI beverages may contribute to improved postprandial vasodilatation. Although one week of low-physical activity led to marked impairment in IS, it had no effect on arterial stiffness in healthy men.
Brave new algebraic geometry and global derived moduli spaces of ring spectra

We develop homotopical algebraic geometry ([To-Ve 1, To-Ve 2]) in the special context where the base symmetric monoidal model category is that of spectra S, i.e. what might be called, after Waldhausen, brave new algebraic geometry. We discuss various model topologies on the model category of commutative algebras in S, and their associated theories of geometric S-stacks (a geometric S-stack being an analog of Artin notion of algebraic stack in Algebraic Geometry). Two examples of geometric S-stacks are given: a global moduli space of associative ring spectrum structures, and the stack of elliptic curves endowed with the sheaf of topological modular forms.
Particulate air pollution standards and morbidity and mortality: case study.

Received for publication May 23, 2001, and accepted for publication August 30, 2001. Abbreviations: CASAC, Clean Air Scientific Advisory Committee; EPA, US Environmental Protection Agency; PM 10 , standard for coarse particulate matter; PM 2.5 , standard for fine particulate matter. 1 Health Effects Institute, Cambridge, MA. 2 Office of Air Quality Planning and Standards, US Environmental Protection Agency, Research Triangle Park, NC. 3 Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada. 4 Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. 5 American Lung Association, Washington, DC. 6 The Electric Power Research Institute, Palo Alto, CA. Reprint requests to Mr. Daniel Greenbaum, President, Health Effects Institute, Charlestown Navy Yard, 120 Second Avenue, Boston, MA 02129-4533 (e-mail: Dgreenbaum@healtheffects.org). EPIDEMIOLOGY AT THE CENTER OF A HIGHLY-VISIBLE NATIONAL DEBATE