Miracle-dz/UniFAR-FTUs huggingface dataset:
The 8p23 Inversion Polymorphism Determines Local Recombination Heterogeneity across Human Populations

For decades, chromosomal inversions have been regarded as fascinating evolutionary elements as they are expected to suppress recombination between chromosomes with opposite orientations, leading to the accumulation of genetic differences between the two configurations over time. Here, making use of publicly available population genotype data for the largest polymorphic inversion in the human genome (8p23-inv), we assessed whether this inhibitory effect of inversion rearrangements led to significant differences in the recombination landscape of two homologous DNA segments, with opposite orientation. Our analysis revealed that the accumulation of genetic differentiation is positively correlated with the variation in recombination profiles. The observed recombination dissimilarity between inversion types is consistent across all populations analyzed and surpasses the effects of geographic structure, suggesting that both structures (orientations) have been evolving independently over an extended period of time, despite being subjected to the very same demographic history. Aside this mainly independent evolution, we also identified a short segment (350 kb, <10% of the whole inversion) in the central region of the inversion where the genetic divergence between the two structural haplotypes is diminished. Although it is difficult to demonstrate it, this could be due to gene flow (possibly via double-crossing over events), which is consistent with the higher recombination rates surrounding this segment. This study demonstrates for the first time that chromosomal inversions influence the recombination landscape at a fine-scale and highlights the role of these rearrangements as drivers of genome evolution.
LYMPHOID CELLS MEDIATING TUMOR-SPECIFIC CYTOTOXICITY TO CARCINOMA OF THE URINARY BLADDER

Peripheral lymphocytes from patients with urinary bladder carcinoma and controls have been separated on the basis of rosette formation with sheep erythrocytes. The fractions were tested for tumor-specific cytotoxicity. The E rosette-forming cells of purity ⩾ 90% respond well in PHA-induced cytotoxicity but are totally inactive in the tumor assay. The non-E rosette-forming cells (purity ⩾ 91%) give enhanced activity in the tumor-specific cytotoxicity as well as in antibody-mediated target cell lysis in a model system. These data support the notion that the effector cells in cell-mediated immunity to carcinoma of the urinary bladder are members of the nonthymus-derived population of peripheral lymphocytes.
Hostility, smiling and elicited emotional experiences: Considerations for health outcomes.

Resilience is an increasingly invoked theoretical construct to explain why and how people manage to retain their health despite experiencing adversity. Improved vagal tone (higher heart rate variability; HRV) is supported in the literature as an indicator of positive cardiovascular health outcomes. Utilizing a measure of HRV as a proxy for health resilience outcomes, historical datasets of healthy undergraduate students were utilized to elucidate the relationship between measured hostility (high and low), evoked emotions (happy and angry) and smiling behaviours to better understand some factors contributing to positive physiological health (i.e., heart rate variability as an indicator of positive health outcomes). Results indicate that smile parameters vary meaningfully as a function of the type of elicited emotion interview participants undergo and as a function of gender and hostility level. However, the smiling behaviour was not predictive of physiological outcomes.
A model of rural conflict: violence and land reform policy in Brazil

This paper analyzes the underlying determinants of rural land conflicts in Brazil involving squatters, landowners, the federal government, the courts and INCRA, the land reform agency. A model is presented whereby squatters and landowners strategically choose to engage in violence. Landowners use violence as a means of increasing the likelihood of successful eviction of squatters, and squatters use violence to increase the probability that the farm will be expropriated in their favor as part of the government's land reform program. The model's predictions are tested using state level data for Brazil for 22 states from 1988 through 1995. It is shown that the government's land reform policy, which is based on expropriation and settlement projects, paradoxically may be encouraging both sides to engage in more violence, rather than reducing conflicts.
Some results on Bessel functionals for GSp(4)

We prove that every irreducible, admissible representation of GSp(4,F), where F is a non-archimedean local field of characteristic zero, admits a Bessel functional, provided the representation is not one-dimensional. Given such a representation, we explicitly determine the set of all split Bessel functionals admitted by the representation, and prove that these functionals are unique. If the representation is not supercuspidal, or in an L-packet with a non-supercuspidal representation, we explicitly determine the set of all Bessel functionals admitted by the representation, and prove that these functionals are unique.
Thermodynamics of large-Nf QCD at finite chemical potential

We extend the previously obtained results for the thermodynamic potential of hot QCD in the limit of large number of fermions to non-vanishing chemical potential. We give exact results for the thermal pressure in the entire range of temperature and chemical potential for which the presence of a Landau pole is negligible numerically. In addition we compute linear and non-linear quark susceptibilities at zero chemical potential, and the entropy at small temperatures. We compare with the available perturbative results and determine their range of applicability. Our numerical accuracy is sufficiently high to check and verify existing results, including the recent perturbative results by Vuorinen on quark number susceptibilities and the older results by Freedman and McLerran on the pressure at zero temperature and high chemical potential. We also obtain a number of perturbative coefficients at fourth and sixth order in the coupling that have not yet been calculated analytically. In the case of both non-zero temperature and non-zero chemical potential, we investigate the range of validity of a scaling behaviour noticed recently in lattice calculations by Fodor, Katz, and Szabo at moderately large chemical potential and find that it breaks down rather abruptly at ? q? T, which points to a presumably generic obstruction for extrapolating data from small to large chemical potential. At sufficiently small temperatures T << ? q, we find dominating non-Fermi-liquid contributions to the interaction part of the entropy, which exhibits strong nonlinearity in the temperature and an excess over the free-theory value.
Investigating Procrastination in Higher Education

This study aims at investigating procrastination among students in higher education. Procrastination has been studied in many fields including Psychology, Mental Health, and Educational studies. This study brings the important idea to the study of procrastination. Unlike other perspectives, this study only focused on academic procrastination where the students delay their efforts to complete any academic tasks. Participants were 230 college students majoring in Educational Psychology and Guidance. The students (N= 349 students) were recruited randomly for the survey. The data, then, were analyzed using quantitative approach. The results showed that most participants (43.04%) were less involved in procrastination while few of them (10.87%) showed low frequency of procrastination. This research suggested that the moderate level of procrastination indicated a high degree of procrastination.
Information relationships and measures: an analysis apparatus for efficient information system synthesis

The analysis of information relationships is of primary importance for the analysis and synthesis of digital information systems. The paper aims to introduce and discuss the fundamental apparatus for the analysis and evaluation of information relationships. It defines and explains various relationships between information, measures for the amount and importance of information, and measures for the strength and importance of the information relationships. It demonstrates importance of the introduced relationships and measures for efficient synthesis, and shows how to apply them in the synthesis process. The analysis apparatus makes operational the famous theory of partitions and set systems of Hartmanis (1966). While partitions and set systems enable one to model information, the relationships and measures enable one to analyze and measure information and information relationships. Both together form a complete information modeling and analysis apparatus that can be applied in logic design, decision system design, pattern recognition, knowledge discovery, machine learning and other areas.
Cycle Flux Algebra for Ion and Water Flux through the KcsA Channel Single-File Pore Links Microscopic Trajectories and Macroscopic Observables

In narrow pore ion channels, ions and water molecules diffuse in a single-file manner and cannot pass each other. Under such constraints, ion and water fluxes are coupled, leading to experimentally observable phenomena such as the streaming potential. Analysis of this coupled flux would provide unprecedented insights into the mechanism of permeation. In this study, ion and water permeation through the KcsA potassium channel was the focus, for which an eight-state discrete-state Markov model has been proposed based on the crystal structure, exhibiting four ion-binding sites. Random transitions on the model lead to the generation of the net flux. Here we introduced the concept of cycle flux to derive exact solutions of experimental observables from the permeation model. There are multiple cyclic paths on the model, and random transitions complete the cycles. The rate of cycle completion is called the cycle flux. The net flux is generated by a combination of cyclic paths with their own cycle flux. T.L. Hill developed a graphical method of exact solutions for the cycle flux. This method was extended to calculate one-way cycle fluxes of the KcsA channel. By assigning the stoichiometric numbers for ion and water transfer to each cycle, we established a method to calculate the water-ion coupling ratio (CR w-i) through cycle flux algebra. These calculations predicted that CR w-i would increase at low potassium concentrations. One envisions an intuitive picture of permeation as random transitions among cyclic paths, and the relative contributions of the cycle fluxes afford experimental observables.
Service-oriented computing: concepts, characteristics and directions

Service-oriented computing (SOC) is the computing paradigm that utilizes services as fundamental elements for developing applications/solutions. To build the service model, SOC relies on the service oriented architecture (SOA), which is a way of reorganizing software applications and infrastructure into a set of interacting services. However, the basic SOA does not address overarching concerns such as management, service orchestration, service transaction management and coordination, security, and other concerns that apply to all components in a service architecture. In this paper we introduce an extended service oriented architecture that provides separate tiers for composing and coordinating services and for managing services in an open marketplace by employing grid services.
The one‐point PDF of the initial conditions of our local Universe from the IRAS PSC redshift catalogue

The algorithm ZTRACE of Monaco & Efstathiou (1999) is applied to the IRAS PSCz catalogue to reconstruct the initial conditions of our local Universe with a resolution down to �5 h 1 Mpc. The 1-point PDF of the reconstructed initial conditions is consistent with the assumptions that (i) IRAS galaxies trace mass on scales of �5 h 1 Mpc, and (ii) the statistics of primordial density fluctuations is Gaussian. We use simulated PSCz catalogues, constructed from N-body simulations with Gaussian initial conditions, to show that local non-linear bias can cause the recovered initial PDF (assuming no bias) to be non-Gaussian. However, for plausible bias models, the distortions of the recovered PDF would be difficult to detect using the volume finely sampled by the PSCz catalogue. So, for Gaussian initial conditions, a range of bias models remain compatible with our PSCz reconstruction results.
Task Allocation for Undependable Multiagent Systems in Social Networks

Task execution of multiagent systems in social networks (MAS-SN) can be described through agents' operations when accessing necessary resources distributed in the social networks; thus, task allocation can be implemented based on the agents' access to the resources required for each task and aimed to minimize this resource access time. Currently, in undependable MAS-SN, there are deceptive agents that may fabricate their resource status information during task allocation but not really contribute resources to task execution; although there are some game theory-based solutions for undependable MAS, but which do not consider minimizing resource access time that is crucial to the performance of task execution in social networks. To achieve dependable resources with the least access time to execute tasks in undependable MAS-SN, this paper presents a novel task allocation model based on the negotiation reputation mechanism, where an agent's past behaviors in the resource negotiation of task execution can influence its probability to be allocated new tasks in the future. In this model, the agent that contributes more dependable resources with less access time during task execution is rewarded with a higher negotiation reputation, and may receive preferential allocation of new tasks. Through experiments, we determine that our task allocation model is superior to the traditional resources-based allocation approaches and game theory-based allocation approaches in terms of both the task allocation success rate and task execution time and that it usually performs close to the ideal approach (in which deceptive agents are fully detected) in terms of task execution time.
Automated detection of smuggled high-risk security threats using Deep Learning

The security infrastructure is ill-equipped to detect and deter the smuggling of non-explosive devices that enable terror attacks such as those recently perpetrated in western Europe. The detection of so-called "small metallic threats" (SMTs) in cargo containers currently relies on statistical risk analysis, intelligence reports, and visual inspection of X-ray images by security officers. The latter is very slow and unreliable due to the difficulty of the task: objects potentially spanning less than 50 pixels have to be detected in images containing more than 2 million pixels against very complex and cluttered backgrounds. In this contribution, we demonstrate for the first time the use of Convolutional Neural Networks (CNNs), a type of Deep Learning, to automate the detection of SMTs in fullsize X-ray images of cargo containers. Novel approaches for dataset augmentation allowed to train CNNs from-scratch despite the scarcity of data available. We report fewer than 6% false alarms when detecting 90% SMTs synthetically concealed in stream-of-commerce images, which corresponds to an improvement of over an order of magnitude over conventional approaches such as Bag-of-Words (BoWs). The proposed scheme offers potentially super-human performance for a fraction of the time it would take for a security officers to carry out visual inspection (processing time is approximately 3.5s per container image).
Improvising in the vulnerable encounter: Using improvised participatory theatre in change for healthcare practice

Healthcare practitioners are often presented with vulnerable encounters where their professional experience is insufficient when dealing with patients who suffer from illnesses such as chronic pain. How can one otherwise understand chronic pain and develop practices whereby medical healthcare practitioners can experience alternative ways of doing their practice? This essay describes how a group of researchers have, over a number of years, developed improvised participatory theatre as a means of engaging healthcare practitioners, patients and other lay people in situations where it is legitimate to reappraise their practice and reunderstand the nature of an illness such as chronic pain. One conclusion was to consider that it is a relational rather than an individual phenomenon that in turn demands alternative practice. Through iterative workshop processes of improvised theatre, participants are encouraged to experience the vulnerable, the unknown, and the need to be alternatively present when dealing with patients whose situation is imbued with suffering.
Prevalence of Celiac Disease in Iranian Children with Recurrent Abdominal Pain Referred to a Pediatric Referral Center

Objective Clinical features of Iranian children with celiac disease (CD) are still unknown and there is scant information about atypical presentation of celiac disease from Iran. The aim of this study was to determine prevalence of CD in Iranian children presenting with functional abdominal pain (FAP). Methods In this cross-sectional study, 301 children affected by FAP were screened for CD by anti-tissue transglutaminase antibody (tTG IgA). IgA antibody was also measured to exclude IgA deficiency. The antibodies were measured by enzyme linked immunosorbent assay. Diagnosis of CD was confirmed by duodenal biopsy that was scored according to the Marsh classification in cases with abnormal titer of tTG antibody. Findings A total of 301 children (138 males, 163 females) with FAP were studied. Endoscopic duodenal biopsy was taken for patients with positive and borderline tTG test. Two out of 301 cases were IgA deficient and celiac disease was suspected for one of them based on histological findings. Four out of 299 patients with normal IgA had abnormal tTG titer; intermediate ranges (16–23 U/ml) were detected in 1 and positive ranges (≥24 U/ml) in 3 cases. CD was suggested in all patients with abnormal titer of tTG (1.33%) based on histological findings. Conclusion The prevalence of celiac disease in children with FAP is estimated 1.3% (nearly 2 times higher than in normal population) in Iran.
Neutral Hydrogen (21 Centimeter) Absorption in Seyfert Galaxies: Evidence for Free-Free Absorption and Subkiloparsec Gaseous Disks

Active galaxies are thought to be both fueled and obscured by neutral gas removed from the host galaxy and funneled into a central accretion disk. We performed a VLA imaging survey of 21 cm absorption in Seyfert and starburst nuclei to study the neutral gas in the near-nuclear environment. With the exception of NGC 4151, the absorbing gas traces 100 pc-scale, rotating disks aligned with the outer galaxy disk. These disks appear to be rich in atomic gas relative to nuclear disks in nonactive spirals. We find no strong evidence for rapid infall or outflow of neutral hydrogen, but our limits on the mass infall rates are compatible with that required to feed a Seyfert nucleus. Among the galaxies surveyed here, neutral hydrogen absorption traces parsec-scale gas only in NGC 4151. Based on the kinematics of the absorption line, the disk symmetry axis appears to align with the radio jet axis rather than the outer galaxy axis. The most surprising result is that we detect no 21 cm absorption toward the central radio sources of the hidden Seyfert 1 nuclei Mrk 3, Mrk 348, and NGC 1068. Moreover, 21 cm absorption is commonly observed toward extended radio jet structure but appears to avoid central, compact radio sources in Seyfert nuclei. To explain these results, we propose that 21 cm absorption toward the nucleus is suppressed by either free-free absorption, excitation effects (i.e., enhanced spin temperature), or rapid motion in the obscuring gas. Ironically, the implications of these effects is that the obscuring disks must be small, typically not larger than a few tens of parsecs.
Decision-Making Processes Among Potential Dropouts in Vocational Education and Training and Adult Learning

Context: Aiming at gaining knowledge about students' thoughts and actions in deciding to stay in or drop out of an educational programme, an empirical study was conducted on dropout among 18-24-year-old students in VET and basic general adult learning. Approach: In order to pursue this aim, the study combined two sets of data: weekly student surveys and interviews with these same students. While the surveys provide a weekly snapshot of the students' thoughts regarding the probability of them continuing in the programme, their satisfaction with the educational programme as a whole, the specific lessons they attend, and the atmosphere at the school, the interviews contribute with detailed descriptions of the students' thoughts on the same matters.Findings: Based on the students' answers over an eight-week period, it was possible to trace a graph illustrating changes in the students' attitudes. These graphs can be placed within four categories of development: the stable, the positive, the unstable, and the negative. The latter can furthermore be differentiated as reflecting a stable decline, a fluctuating decline, or a sudden decline. In the interviews, the aim was to elicit the individual students' thoughts and actions at the points when their graphs took a turn. Conclusions: The findings show that the students' thoughts and actions concern matters both inside and outside the school. Furthermore, seemingly trivial matters in the students' lives are shown to have a potentially decisive influence on the students' thoughts about staying in or dropping out of a programme. These findings confirm the importance of focusing on students' decision-making processes in research on dropout. However, further research is needed to increase understanding of processes leading to decisions to drop out of education, including the qualification of methods to capture these processes.
A General Equilibrium Model of Statistical Discrimination

We consider a general equilibrium model with endogenous human capital formation in which ex ante identical groups may be treated differently in equilibrium due to informational externalities. Unlike earlier models of statistical discrimination, group inequalities may arise even if the corresponding model with a single group has a unique equilibrium. The dominant group gains from discrimination, rationalizing why a majority may be reluctant to eliminate discrimination. The model is also consistent with "reverse discrimination" as a remedy against discrimination since it may require to decrease the welfare of the dominant group to achieve parity.
A W-band miniature power divider based on E-faced-folded magic-T junction

A novel design of W-band power divider using E-faced-folded waveguide magic-T junction to realize the miniaturization is proposed in this paper. A stepped regular triangular prism and the stepped impedance transformer are utilized in order to obtain excellent performance. Besides, the performance of the E-faced-folded magic-T power divider is also improved by using short planes. The measured results show that the insertion loss of the power divider is better than 0.6dB and the return loss is better than 15dB. The measured average E-H isolation is better than 30dB from 92GHz to 100GHz range.