Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of an X-ray periodicity in the Seyfert galaxy IRAS 18325–5926

We report the detection of a 5.8 A– 104 s periodicity in the 0.5–10 keV X-ray light curve of the Seyfert galaxy IRAS 18325–5926, obtained from a 5-d ASCA observation. Nearly nine cycles of the periodic variation are seen; it shows no strong energy dependence and has an amplitude of about 15 per cent. Unlike most other well-studied Seyfert galaxies, there is no evidence for strong power-law red noise in the X-ray power spectrum of IRAS 18325–5926. Scaling from the QPOs found in Galactic black hole candidates suggests that the mass of the black hole in IRAS 18325–5926 is ∼ 6 A– 106–4 A– 107 M⊙.
Performance evaluation of TCP/IP in Bluetooth based systems

In a TCP/IP connection over a Bluetooth wireless link, the temporal correlation of errors improves performance slightly at low error rates. At a certain cutoff point, performance decreases dramatically due to TCP/IP timeouts, retransmits, and window shrinking. When two channels are modelled by both spatial and temporal correlation, the effect of "correlation sharing" can readily be seen.
Propiedades psicométricas de la Escala de Control Psicológico orientado a la Dependencia y a la Autocrítica (DAPCS-S) en adolescentes tardíos de Lima

Se estudiaron las propiedades psicometricas de la Escala de Control Psicologico orientado a la Dependencia y a la Autocritica traducida al espanol y adaptada al Peru (DAPCS-S) en una muestra de adolescentes de Lima. Asi, se aplico el cuestionario DAPCS-S a una muestra de 292 participantes de dos universidades privadas. Se estudio la estructura interna de la escala mediante el uso de diversos analisis de componentes principales y analisis factoriales confirmatorios. Se encontro que la estructura bifactorial (Control psicologico orientado a la Dependencia y a la Autocritica) propuesta en la escala (Soenens et al., 2010) pudo ser reproducida satisfactoriamente. Los resultados del establecimiento la validez convergente y discriminante de la escala fueron de acuerdo con lo esperado. Finalmente, la confiabilidad de las escalas de control psicologico fue satisfactoria.
Market Power, Human Capital and Growth *

In this paper we study the economic determinants of the inter-sectoral distribution of skilled workers and the long-run consequences of imperfect competition on growth within an R&D-based growth model with human capital accumulation. We find that steady-state growth is driven only by incentives to accumulate human capital and is independent of scale effects. In the model imperfect competition has a positive growth effect, while influencing the allocation of human capital to the diferent economic activities. Contrary to general wisdom, high R&D investment is not always associated with high output growth.
Relative Bioavailability of Niacin Supplements for Dairy Cows: Effects of Rumen Protection and of Feed Processing

The present study aimed to examine the effective systemic bioavailability of niacin— with particular focus on its galenic form—and feed processing. Experiment 1 was conducted with 35 dairy cows to investigate the effects of various doses of oral supplemented nicotinic acid (NA) either in differing galenic forms (non-rumen protected (nRP) vs. rumen protected form (RP)) on serum niacin concentrations. Experiment 2 was designed as a pharmacokinetic study examining the serum niacin kinetics over 24 h after giving a single oral bolus of 24 g nRP or RP NA admixed in either pelleted or ground concentrate. In both experiments, only the niacin vitamer nicotinamide (NAM) was detected. Results of experiment 1 showed that both galenic forms at a dose of 24 g/cow daily elevated NAM concentrations at the beginning of the experiment. Despite a daily supplementation, NAM concentrations decreased continuously towards the end of the experiment which was more steeply in nRP NA (p = 0.03). On experimental day 21, NAM concentrations were higher when feeding RP NA (p = 0.03) and the highest dose (24 g/day and cow) (p < 0.01). Results of experiment 2 indicated that nRP and RP were characterized by similar pharmacokinetic profiles resulting in similar areas under the curves as a net result of the kinetic counterbalancing alterations. Pelleting seemed not to influence the relative bioavailability.
DERIVING STELLAR EFFECTIVE TEMPERATURES OF METAL-POOR STARS WITH THE EXCITATION POTENTIAL METHOD

It is well established that stellar effective temperatures determined from photometry and spectroscopy yield systematically different results. We describe a new, simple method to correct spectroscopically derived temperatures (“excitation temperatures”) of metal-poor stars based on a literature sample with −3.3 < [Fe/H] < −2.5. Excitation temperatures were determined from Fe i line abundances in high-resolution optical spectra in the wavelength range of ∼3700–∼7000 Å, although shorter wavelength ranges, up to 4750–6800 Å, can also be employed, and compared with photometric literature temperatures. Our adjustment scheme increases the temperatures up to several hundred degrees for cool red giants, while leaving the near-main-sequence stars mostly unchanged. Hence, it brings the excitation temperatures in good agreement with photometrically derived values. The modified temperature also influences other stellar parameters, as the Fe i–Fe ii ionization balance is simultaneously used to determine the surface gravity, while also forcing no abundance trend on the absorption line strengths to obtain the microturbulent velocity. As a result of increasing the temperature, the often too low gravities and too high microturbulent velocities in red giants become higher and lower, respectively. Our adjustment scheme thus continues to build on the advantage of deriving temperatures from spectroscopy alone, independent of reddening, while at the same time producing stellar chemical abundances that are more straightforwardly comparable to studies based on photometrically derived temperatures. Hence, our method may prove beneficial for comparing different studies in the literature as well as the many high-resolution stellar spectroscopic surveys that are or will be carried out in the next few years.
Effects of concussion on attention and executive function in adolescents.

BACKGROUND Head trauma in adolescents has been linked with deficits in attention and executive function that can compromise the performance of everyday tasks. Although previous research has examined this issue using computerized neuropsychological testing, little work has been done using laboratory-based measurements of attention and executive function in this population. A longitudinal analysis of recovery patterns of these measures among adolescents is central to understanding the effects of concussions across the age spectrum. PURPOSE This study prospectively and longitudinally examined laboratory-based measures of attention and executive function in concussed adolescents sequentially during a 2-month period after injury. METHODS Two measures of attention and executive function, the Attentional Network Test and the Task-Switching Test, were administered to 20 concussed adolescents within 72 h postinjury as well as at 1 wk, 2 wk, 1 month, and 2 months postinjury. Twenty healthy, matched control subjects were similarly assessed at the same time intervals. Data were analyzed by two-way, mixed-effects ANOVA to determine the effect of group and time on the dependent variables. RESULTS Compared with control subjects, the concussed group exhibited a significantly greater switch cost on the Task-Switching Test (P = 0.038, mean difference value = 38 ms) and a significantly greater reaction time for the Attentional Network Test conflict effect component (P = 0.015, mean difference value = 34 ms) for up to 2 months after injury. CONCLUSIONS Concussed adolescents have difficulty recovering executive function after injury and may require extended recuperation time before full recovery is achieved. Evaluations focusing on attention and executive function can be useful additions in the assessment and follow-up after head injury.
Using Syntactic Dependencies and WordNet Classes for Noun Event Recognition

The goal of this research is to devise a method for recognizing TimeML noun events in a more effective way. TimeML is the most recent annotation scheme for processing the event and temporal expressions in natural language processing fields. In this paper, we argue and demonstrate that the dependencies and the deep-level WordNet classes are useful for recognizing events. We formulate the event recognition problem as a classification task using various features including lexical semantic and dependency-based features. The experimental results show that our proposed method outperforms significantly a state-of-the-art approach. Our analysis of the results demonstrates that the dependencies of direct object and the deep-level WordNet hypernyms play pivotal roles for recognizing noun events.
SUPPORT VECTOR MACHINES FOR OBJECT RECOGNITION UNDER VARYING ILLUMINATION CONDITIONS

We propose an appearance-based method for object recognition under varying illumination conditions. It is known that images of an object under varying illumination conditions lie in a convex cone formed in the image space. In addition, variations due to changes in light intensity can be canceled by normalizing images. Based on these observations, our proposed method combines binary classiﬁcations using discriminant hyperplanes in the normalized image space. For obtaining these hyperplanes, we compared Support Vector Machine (SVM), which has been used successfully for object recognition under varying poses, and Fisher’s linear discriminant (FLD). We have conducted a number of experiments by using the Yale Face Database B and conﬁrmed that SVMs are effective also for object recognition under varying illumination conditions.
Novel Processed Form of Syndecan-1 Shed from SCC-9 Cells Plays a Role in Cell Migration

The extracellular milieu is comprised in part by products of cellular secretion and cell surface shedding. The presence of such molecules of the sheddome and secretome in the context of the extracellular milieu may have important clinical implications. In cancer they have been hypothesized to play a role in tumor growth and metastasis. The objective of this study was to evaluate whether the sheddome/secretome from two cell lines could be correlated with their potential for tumor development. Two epithelial cell lines, HaCaT and SCC-9, were chosen based on their differing abilities to form tumors in animal models of tumorigenesis. These cell lines when stimulated with phorbol-ester (PMA) showed different characteristics as assessed by cell migration, adhesion and higher gelatinase activity. Proteomic analysis of the media from these treated cells identified interesting, functionally relevant differences in their sheddome/secretome. Among the shed proteins, soluble syndecan-1 was found only in media from stimulated tumorigenic cells (SCC-9) and its fragments were observed in higher amount in the stimulated tumorigenic cells than stimulated non-tumorigenic cells (HaCaT). The increase in soluble syndecan-1 was associated with a decrease in membrane-bound syndecan-1 of SCC-9 cells after PMA stimuli. To support a functional role for soluble syndecan-1 fragments we demonstrated that the synthetic syndecan-1 peptide was able to induce cell migration in both cell lines. Taken together, these results suggested that PMA stimulation alters the sheddome/secretome of the tumorigenic cell line SCC-9 and one such component, the syndecan-1 peptide identified in this study, was revealed to promote migration in these epithelial cell lines.
Eurographics/ Ieee-vgtc Symposium on Visualization 2008 Code Flows: Visualizing Structural Evolution of Source Code

Understanding detailed changes done to source code is of great importance in software maintenance. We present Code Flows, a method to visualize the evolution of source code geared to the understanding of fine and mid-level scale changes across several file versions. We enhance an existing visual metaphor to depict software structure changes with techniques that emphasize both following unchanged code as well as detecting and highlighting important events such as code drift, splits, merges, insertions and deletions. The method is illustrated with the analysis of a real-world C++ code system.
Failed Agility LP Total Ankle Replacement with Severe >40 Varus DeformityRevision with Prosthesis Conversion and Soft-Tissue Procedures Alone

Achieving frontal plane alignment of the ankle joint during primary and revision total ankle replacement is essential for long-term success. This manuscript presents the revision of a failed Agility™ LP total ankle replacement system with severe > 40° varus ankle deformity that was corrected with explanation and conversion to an INBONE™ II total ankle system coupled with soft-tissue release/reconstruction employing percutaneous Achilles tendon lengthening, posterior tibial tendon intramuscular recession lengthening and modified Evans peroneus longus lateral ankle stabilization. Additionally, prophylactic tarsal tunnel release was performed to reduce potential for postoperative nerve compression. At short-term 2.5-years follow-up the patient had a well-balanced and painless foot/ ankle and return of a functional lower limb.
Single-molecule microscopy reveals new insights into nucleotide selection by DNA polymerase I

The mechanism by which DNA polymerases achieve their extraordinary accuracy has been intensely studied because of the linkage between this process and mutagenesis and carcinogenesis. Here, we have used single-molecule fluorescence microscopy to study the process of nucleotide selection and exonuclease action. Our results show that the binding of Escherichia coli DNA polymerase I (Klenow fragment) to a primer-template is stabilized by the presence of the next correct dNTP, even in the presence of a large excess of the other dNTPs and rNTPs. These results are consistent with a model where nucleotide selection occurs in the open complex prior to the formation of a closed ternary complex. Our assay can also distinguish between primer binding to the polymerase or exonuclease domain and, contrary to ensemble-averaged studies, we find that stable exonuclease binding only occurs with a mismatched primer terminus.
Fine-scale population epigenetic structure in relation to gastrointestinal parasite load in red grouse (Lagopus lagopus scotica)

Epigenetic modification of cytosine methylation states can be elicited by environmental stresses and may be a key process affecting phenotypic plasticity and adaptation. Parasites are potent stressors with profound physiological and ecological effects on their host, but there is little understanding in how parasites may influence host methylation states. Here, we estimate epigenetic diversity and differentiation among 21 populations of red grouse (Lagopus lagopus scotica) in north‐east Scotland and test for association of gastrointestinal parasite load (caecal nematode Trichostrongylus tenuis) with hepatic genome‐wide and locus‐specific methylation states. Following methylation‐sensitive AFLP (MSAP), 129 bands, representing 73 methylation‐susceptible and 56 nonmethylated epiloci, were scored across 234 individuals. The populations differed significantly in genome‐wide methylation levels and were also significantly epigenetically (FSC = 0.0227; P < 0.001) and genetically (FSC = 0.0058; P < 0.001) differentiated. Parasite load was not associated with either genome‐wide methylation levels or epigenetic differentiation. Instead, we found eight disproportionately differentiated epilocus‐specific methylation states (FST outliers) using bayescan software and significant positive and negative association of 35 methylation states with parasite load from bespoke generalized estimating equations (GEE), simple logistic regression (sam) and Bayesian environmental analysis (bayenv2). Following Sanger sequencing, genome mapping and geneontology (go) annotation, some of these epiloci were linked to genes involved in regulation of cell cycle, signalling, metabolism, immune system and notably rRNA methylation, histone acetylation and small RNAs. These findings demonstrate an epigenetic signature of parasite load in populations of a wild bird and suggest intriguing physiological effects of parasite‐associated cytosine methylation.
Predominantly Cystic Central Mucoepidermoid Carcinoma Developing from a Previously Diagnosed Dentigerous Cyst: Case Report and Review of the Literature

Primary intraosseous mucoepidermoid carcinoma of the jawbones is an extremely rare malignant salivary gland tumour constituting 2-4.3% of all the reported mucoepidermoid carcinomas. We report a case of intraosseous mucoepidermoid carcinoma of the mandible in an 80-year old female patient developing from a previously diagnosed dentigerous cyst. An excisional biopsy was performed and the histopathological features confirmed low grade-cystic intraosseous mucoepidermoid carcinoma. The origin of central mucoepidermoid carcinoma could be suggested to be from the epithelial lining of previously diagnosed dentigerous cyst. Thus, emphasizing the need for careful examination of the entire excision specimen to rule out such neoplastic transformation of epithelial lining of odontogenic cyst and provide appropriate and effective treatment.
Phospho-sulindac inhibits pancreatic cancer growth: NFATc1 as a drug resistance candidate

Phospho-sulindac (P-S), a promising anticancer agent, is efficacious in pre-clinical models of human cancer and is apparently safe. Here, we studied the effect of P-S on pancreatic cancer growth. We found that P-S strongly inhibits the growth of human pancreatic cancer cells in vitro, is efficacious in inhibiting the growth of pancreatic xenografts in nude mice, and has an excellent safety profile. Microarray analysis revealed that P-S induced the expression of nuclear factor of activated T-cells, isoform c1 (NFATc1) gene. NFATc1, a calcineurin-responsive transcription factor associated with aggressive pancreatic cancer. The role of increased NFATc1 expression on the growth inhibitory effect of P-S on cancer growth was evaluated by silencing or by overexpressing it both in vitro and in vivo. We found that when the expression of NFATc1 was abrogated by RNAi, pancreatic cancer cells were more responsive to treatment with P-S. Conversely, over-expressing the NFATc1 gene made the pancreatic cancer cells less responsive to treatment with P-S. NFATc1 likely mediates drug resistance to P-S and is an unfavorable prognostic factor that predicts poor tumor response. We also demonstrated that NFATc1-mediated resistance can be overcome by cyclosporin A (CsA), an NFAT inhibitor, and that the combination of P-S and CsA synergistically inhibited pancreatic cancer cell growth. In conclusion, our preclinical data establish P-S as an efficacious drug for pancreatic cancer in preclinical models, which merits further evaluation.
The Mass Distribution and Lifetime of Prestellar Cores in Perseus, Serpens, and Ophiuchus

We present an unbiased census of starless cores in Perseus, Serpens, and Ophiuchus, assembled by comparing large-scale Bolocam 1.1 mm continuum emission maps with Spitzer c2d surveys. We use the c2d catalogs to separate 108 starless from 92 protostellar cores in the 1.1 mm core samples from Enoch and Young and their coworkers. A comparison of these populations reveals the initial conditions of the starless cores. Starless cores in Perseus have similar masses but larger sizes and lower densities on average than protostellar cores, with sizes that suggest density profiles substantially flatter than ρ ∝ r−2. By contrast, starless cores in Serpens are compact and have lower masses than protostellar cores; future star formation will likely result in lower mass objects than the currently forming protostars. Comparison to dynamical masses estimated from the NH3 survey of Perseus cores by Rosolowsky and coworkers suggests that most of the starless cores are likely to be gravitationally bound, and thus prestellar. The combined prestellar core mass distribution includes 108 cores and has a slope of α = − 2.3 ± 0.4 for M > 0.8 M☉. This slope is consistent with recent measurements of the stellar initial mass function, providing further evidence that stellar masses are directly linked to the core formation process. We place a lower limit on the core-to-star efficiency of 25%. There are approximately equal numbers of prestellar and protostellar cores in each cloud; thus the dense prestellar core lifetime must be similar to the lifetime of embedded protostars, or 4.5 × 105 yr, with a total uncertainty of a factor of 2. Such a short lifetime suggests a dynamic, rather than quasi-static, core evolution scenario, at least at the relatively high mean densities (n > 2 × 104 cm−3) to which we are sensitive.
SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas

The increased expression of SIRT1 has recently been identified in numerous human tumors and a possible correlation with c-Myc oncogene has been proposed. However, it remains unclear whether SIRT1 functions as an oncogene or tumor suppressor. We sought to elucidate the role of SIRT1 in liver cancer under the influence of c-Myc and to determine the prognostic significance of SIRT1 and c-Myc expression in human hepatocellular carcinoma. The effect of either over-expression or knock down of SIRT1 on cell proliferation and survival was evaluated in both mouse and human liver cancer cells. Nicotinamide, an inhibitor of SIRT1, was also evaluated for its effects on liver tumorigenesis. The prognostic significance of the immunohistochemical detection of SIRT1 and c-Myc was evaluated in 154 hepatocellular carcinoma patients. SIRT1 and c-Myc regulate each other via a positive feedback loop and act synergistically to promote hepatocellular proliferation in both mice and human liver tumor cells. Tumor growth was significantly inhibited by nicotinamide in vivo and in vitro. In human hepatocellular carcinoma, SIRT1 expression positively correlated with c-Myc, Ki67 and p53 expression, as well as high á-fetoprotein level. Moreover, the expression of SIRT1, c-Myc and p53 were independent prognostic indicators of hepatocellular carcinoma. In conclusion, this study demonstrates that SIRT1 expression supports liver tumorigenesis and is closely correlated with oncogenic c-MYC expression. In addition, both SIRT1 and c-Myc may be useful prognostic indicators of hepatocellular carcinoma and SIRT1 targeted therapy may be beneficial in the treatment of hepatocellular carcinoma.
Active Video Game Play in African American Children: The Effect of Gender and BMI on Exertion and Enjoyment

ABSTRACT Applying the uses and gratifications theory (U&G), this study tested the influence of gender, body mass index type and past exercise experience on African American children's Wii game-playing experience and heart rate. A field experiment was conducted with a convenience sample of 51 African American children. Overall, the findings supported the proposition of using Wii games as alternative means of physical activity in African American children and suggested choosing games based on children's background information to maximize the effectiveness.
Fault Diagnosis in the BIST Environment Based on Bisection of Detected Faults

An optimized fault diagnosing procedure in Built-in Self-Test environment is proposed. Instead of bisection of patterns in pseudorandom test sequences, in the proposed bisection procedure the diagnostic information inherent in test patterns is taken into account. Another novelty is the sequential nature of the procedure which allows pruning the search space. Opposite to the classical approach which targets all failing patterns, in the proposed method not all failing patterns are needed to be fixed for diagnosis. The proposed method is compared with three known fault diagnosis methods: classical Binary Search, Doubling and Jumping. Experimental results have demonstrated the advantages of the proposed method compared to the known methods.