Miracle-dz/UniFAR-FTUs huggingface dataset:
Course of illness and the development of vascular disease in individuals with bipolar disorder

For over a century, there have been suggestions of a link between what is currently called bipolar disorder and cardiovascular mortality. In the contemporary epidemiological literature, this risk has been confirmed and approximates twice that expected based on age and gender. To date, however, this information has come primarily from clinical samples, which carry considerable risk of selection bias. The studies contained in this dissertation sought to assess this relationship using methods less vulnerable to selection bias and to determine the role that course of illness and treatments for illness may play in the development of vascular disease. In a nationally representative sample, we confirmed a link between mood disorders and vascular disease, which was particularly pronounced in women with bipolar disorder. In subsequent studies, a dose-response relationship between the duration of clinically significant hypomanic or manic symptoms and both cardiovascular mortality and endothelial function was seen. While medication exposure did not appear related to mortality or endothelial function, first generation antipsychotics were associated with arterial stiffness, an effect apparently mediated by elevations in blood pressure. In cross-sectional samples, our data suggests that vasculopathy is not present early in the course of bipolar disorder although is much greater than expected later in the course of illness. This dissertation purports that vasculopathy develops over the long-term course of bipolar disorder, is proportional to symptom burden, and is influenced by health behaviors and treatments. These findings may provide opportunities for clinicians and those afflicted to intervene to address this excess risk of vascular morbidity and mortality. Abstract Approved: Thesis SupervisorApproved: Thesis Supervisor Title and Department
Actions, Action Sequences and Habits: Evidence That Goal-Directed and Habitual Action Control Are Hierarchically Organized

Behavioral evidence suggests that instrumental conditioning is governed by two forms of action control: a goal-directed and a habit learning process. Model-based reinforcement learning (RL) has been argued to underlie the goal-directed process; however, the way in which it interacts with habits and the structure of the habitual process has remained unclear. According to a flat architecture, the habitual process corresponds to model-free RL, and its interaction with the goal-directed process is coordinated by an external arbitration mechanism. Alternatively, the interaction between these systems has recently been argued to be hierarchical, such that the formation of action sequences underlies habit learning and a goal-directed process selects between goal-directed actions and habitual sequences of actions to reach the goal. Here we used a two-stage decision-making task to test predictions from these accounts. The hierarchical account predicts that, because they are tied to each other as an action sequence, selecting a habitual action in the first stage will be followed by a habitual action in the second stage, whereas the flat account predicts that the statuses of the first and second stage actions are independent of each other. We found, based on subjects' choices and reaction times, that human subjects combined single actions to build action sequences and that the formation of such action sequences was sufficient to explain habitual actions. Furthermore, based on Bayesian model comparison, a family of hierarchical RL models, assuming a hierarchical interaction between habit and goal-directed processes, provided a better fit of the subjects' behavior than a family of flat models. Although these findings do not rule out all possible model-free accounts of instrumental conditioning, they do show such accounts are not necessary to explain habitual actions and provide a new basis for understanding how goal-directed and habitual action control interact.
Mencius: Building Efficient Replicated State Machine for WANs

We present a protocol for general state machine replication - a method that provides strong consistency - that has high performance in a wide-area network. In particular, our protocol Mencius has high throughput under high client load and low latency under low client load even under changing wide-area network environment and client load. We develop our protocol as a derivation from the well-known protocol Paxos. Such a development can be changed or further refined to take advantage of specific network or application requirements.
Uk Corporate Governance and Takeover Performance Merger Outcomes and Managerialism Figure 1b Value of Domestic and Overseas Acquisitions the Regulation of Corporate Governance

This chapter addresses the changing nature of corporate governance in the United Kingdom over recent decades and examines whether these changes have had an impact on the UK market for corporate control. The disappointing outcomes for acquiring company shareholders in the majority of corporate acquisitions, public discontent with some pay deals for top executives and some high profile corporate scandals led in the early 1990s to a call for governance reform. The scrutiny of governance in UK companies has intensified since the publication of the Cadbury Report in 1992 and has resulted in calls for changes in the size, composition and role of boards of directors, in the role of institutional shareholders, the remuneration and appointment of executives, and in legal and accounting regulations. We review the background to these changes and the consequences of the changes since 1990 for governance structures. Finally, we examine whether these changes have affected takeover performance in recent years. Our analysis is specific to the institutional circumstances of the UK although we refer where appropriate to takeover studies in other countries. JEL Classification: G30
The Role of Departmental Leadership for Professional Learning Communities

Purpose: Department heads play a pivotal role in the functioning of departments in secondary schools. However, quantitative research about the role of departmental leadership for the development of professional learning communities (PLCs) in subject departments in secondary schools remains scarce. As PLCs are seen as promising contexts for teachers’ continuous professional development, it is highly relevant to study how department heads can facilitate PLC characteristics in their department. Research methodology: This study examines how two dimensions of departmental leadership (group- and development-oriented) relate to interpersonal PLC characteristics in departments. Survey data were collected from 248 experienced mathematics and French teachers in 62 departments in secondary schools in Flanders (Belgium). Two multilevel regression analyses were conducted with collective responsibility and reflective dialogue as dependent interpersonal PLC characteristics. We controlled for several demographic teacher variables and structural departmental variables. Findings: Our results nurture optimism about the potential of departmental leadership for interpersonal PLC characteristics. More specifically, teachers who perceive high group-oriented departmental leadership experience more collective responsibility in their department. Furthermore, teachers’ perceptions of both group-oriented and development-oriented departmental leadership are significantly related to the reported frequency of teachers’ reflective dialogues. Implications: This study suggests that department heads play a critical role in facilitating interpersonal PLC characteristics in departments. As a result, department heads need to be carefully selected and adequately supported. As this article is one of the first to offer a quantitative perspective on this matter, it offers an instrument for future studies and informs policy about departmental leadership practices.
AGGREGATE TOUGHNESS / ABRASION RESISTANCE AND DURABILITY TESTS RELATED TO ASPHALT CONCRETE PERFORMANCE IN PAVEMENTS By

i DISCLAIMER The contents of this report reflect the views of the authors who are solely responsible for the facts and the accuracy of the data presented herein. The contents do not necessarily reflect the official views and policies of the National Center for Asphalt Technology of Auburn University. This report does not constitute a standard, specification, or regulation. ii ABSTRACT Numerous tests have been developed to empirically characterize aggregate without, necessarily, a strong relationship with the performance of the final products incorporating these aggregates. This seems to be particularly true for aggregate " toughness and abrasion resistance " and " durability and soundness. " The purpose of this research was to identify and evaluate toughness/abrasion resistance and durability/soundness tests for characterizing aggregate used in asphalt concrete and to determine those test methods that best correlate with field performance. Based on a review of literature and specifications, laboratory tests for characterizing aggregate toughness/abrasion resistance and durability/soundness were selected. Sixteen aggregate sources with poor to good performance histories were identified for evaluation with the selected suite of tests. Performance histories of pavements containing these aggregates in asphalt concrete layers were established through personal contacts with state transportation agencies and performance evaluation questionnaires. Aggregate properties from laboratory tests were correlated with field performance. The Micro-Deval and magnesium sulfate soundness tests provide the best correlations with field performance of asphalt concrete, and are recommended for characterizing aggregate toughness/abrasion resistance and durability/soundness.
A default mechanism of spindle orientation based on cell shape is sufficient to generate cell fate diversity in polarised Xenopus blastomeres

The process of oriented divisions of polarised cells is a recurrent mechanism of cell fate diversification in development. It is commonly assumed that a specialised mechanism of spindle alignment into the axis of polarity is a prerequisite for such systems to generate cell fate diversity. Oriented divisions also take place in the frog blastula, where orientation of the spindle into the apicobasal axis of polarised blastomeres generates inner and outer cells with different fates. Here, we show that, in this system, the spindle orients according to the shape of the cells, a mechanism often thought to be a default. We show that in the embryo, fatedifferentiative, perpendicular divisions correlate with a perpendicular long axis and a small apical surface, but the long axis rather then the size of the apical domain defines the division orientation. Mitotic spindles in rounded, yet polarised, isolated Xenopus blastula cells orient randomly, but align into an experimentally introduced long axis when cells are deformed early in the cell cycle. Unlike other systems of oriented divisions, the spindle aligns at prophase, rotation behaviour is rare and restricted to small angle adjustments. Disruption of astral microtubules leads to misalignment of the spindle. These results show that a mechanism of spindle orientation that depends on cell shape rather than cortical polarity can nevertheless generate cell fate diversity from a population of polarised cells.
A parathyroid-hormone-related-protein (PTH-rP)-specific cytotoxic T cell response induced by in vitro stimulation of tumour-infiltrating lymphocytes derived from prostate cancer metastases, with epitope peptide-loaded autologous dendritic cells and low-dose IL-2

Bone metastases are one of the most common events in patients with prostate carcinoma. PTH-rP, a protein produced by prostate carcinoma and other epithelial cancers, is a key agent for the development of bone metastases. A PTH-rP-derived peptide, designated PTR-4 was identified, which is capable to bind HLA-A2.1 molecules and to generate PTH-rP-specific cytotoxic T cell (CTL) lines from healthy HLA-A2.1+ individual peripheral-blood-mononuclear-cells (PBMC). In this model, we investigated the in vitro possibility of generating an efficient PTH-rP specific CTL response by cyclical stimulations with IL-2 and PTR-4 peptide-pulsed autologous dendritic cells (DC), of HLA-A2.1+ tumour infiltrating lymphocytes (TIL) derived from a patient with metastatic prostate carcinoma. A T cell line generated in this way (called TM-PTR-4) had a CD3+, CD5+, CD4–, CD8+, CD45Ro+, CD56– immunophenotype and a HLA-A2.1 restricted cytotoxic activity to PTR-4-peptide pulsed CIR-A2 (HLA-A2.1+) target cells, PTH-rP+/HLA-A2.1+ CIR-A2 transfected with PTH-rP gene, prostate carcinoma LNCaP cells, and autologous metastatic prostate cancer cells (M-CaP). These lymphocytes were not cytotoxic to HLA-A2.1+ targets not producing PTH-rP, such as peptide-unpulsed CIR-A2 and colon carcinoma SW-1463, cell lines. Our results provide evidence that PTR-4 peptide-pulsed autologous DC may break the tolerance of human TIL against the autologous tumour by inducing a PTH-rP-specific CTL immune reaction. In conclusion PTR-4 peptide-pulsed autologous DC may be a promising approach for vaccine-therapy and antigen-specific CTL adoptive immunotherapy of hormone-resistant prostrate cancer. © 2001 Cancer Research Campaign http://www.bjcancer. com
Competitive Reactions to Advertising and Promotion Attacks

How do competitors react to each other's price-promotion and advertising attacks? What are the reasons for the observed reaction behavior? We answer these questions by performing a large-scale empirical study on the short-run and long-run reactions to promotion and advertising shocks in over 400 consumer product categories over a four-year time span.Our results clearly show that the most predominant form of competitive response is passive in nature. When a reaction does occur, it is usually retaliatory in the same instrument, i.e., promotion attacks are countered with promotions, and advertising attacks are countered with advertising. There are very few long-run consequences of any type of reaction behavior. By linking reaction behavior to both cross- and own-effectiveness, we further demonstrate that passive behavior is often a sound strategy, while firms that do opt to retaliate often use ineffective instruments, resulting in "spoiled arms. " Accommodating behavior is observed in only a minority of cases, and often results in a missed sales opportunity when promotional support is reduced. The ultimate impact of most promotion and advertising campaigns depends primarily on the nature of consumer response, not the vigilance of competitors.
Book review: misbehaving: the making of behavioural economics

Reviewer Adam Oliver finds that Richard Thaler’s new book, Misbehaving: The Making of Behavioural Economics, covers the core concepts of behavioural economics, but finds that this book is more a ‘personal intellectual history, supplemented by stories, anecdotes and occasional reposts to past combatants’ that misses two important issues ‘relating to suggestions for the future development of behavioural economics’.
Cognitive deficits in obsessive–compulsive disorder on tests of frontal lobe functions

Individuals with obsessive–compulsive disorder (OCD) display frontal lobe deficits, but there are inconsistencies between various tests of frontal lobe functions and between the results from different studies. The objective of this work was to characterize frontal lobe dysfunctions in OCD patients. Fifteen patients and 17 control subjects matched for age, sex and intelligence were tested on classic tests of frontal lobe functions [Wisconsin Card Sorting Test (WCST) and tests of fluency], a smell identification test and one computerized test: the Intra/Extra Dimension test. The Intra/Extra Dimension test showed a significant difference between the two groups in reversal of response. The test of Figural fluency showed a significant difference between the two groups in numbers of produced figures. There were no differences on the WCST, verbal fluency and the smell identification test.
Performance evaluation of Magneto-Rheological based actuation for haptic feedback in medical applications

This paper reports on the performance evaluation of Magneto-Rheological Fluid (MRF) based actuation systems when used in haptic interfaces. MRF-based actuators exhibit superior characteristics, which can significantly contribute to the transparency and stability of haptic devices. To validate this statement, a prototype two degrees-of-freedom (DoF) haptic interface is constructed. A distributed antagonistic configuration is used in order to develop the 2-DoF haptic interface based on small-scale MRF-based clutches for a class of medical applications. The developed device is compared with three conventional haptic interfaces and their stability is compared using the Virtual Wall experiment. Next, the prototype interface is incorporated in a master-slave teleoperation medical setup. Preliminary studies on the performance of the haptic interface show great potential of MRF-based actuators for integration in haptic devices for medical interventions that require safe, accurate, and stable force representation.
Redescription of Heligmosomoides neopolygyrus, Asakawa and Ohbayashi, 1986 (Nematoda: Heligmosomidae) from a Chinese Rodent, Apodemus peninsulae (Rodentia: Muridae); with comments on Heligmosomoides polygyrus polygyrus (Dujardin, 1845) and related species in China and Japan

Heligmosomoides neopolygyrus, Asakawa and Ohbayashi, 1986 (Nematoda, Heligmosomoidea) is redescribed from Apodemus peninsulae from Rangtang, Sichuan, China. A morphological review of the Heligmosomoides spp. belonging to the “polygyrus line” proposed by Asakawa (1988) is made using new characters. This enabled us to distinguish two subspecies in Mus musculus (Heligmosomoides polygyrus bakeri from Japan and H. p. polygyrus from China) and two valid species in Apodemus spp. (H. neopolygyrus from Japan [in A. peninsulae] and from China [in A. agrarius] and H. asakawae from China [in A. uralensis]). Three parasite species of A. agrarius and A. peninsulae, previously identified by Asakawa et al. (1993) as H. neopolygyrus, are considered to be Heligmosomoides incertae sedis. This is the first report of H. neopolygyrus in A. peninsulae from China.
Learning and Reversal Learning in the Subcortical Limbic System: A Computational Model

We present a biologically inspired model of the subcortical nuclei of the limbic system that is capable of performing reversal learning in a food-seeking task. In contrast to previous models, the reversal is modeled by the inhibition of the previously learned behavior. This allows for the reinstatement of behavior to recur quickly, as observed in animal behavior. In this model learning is achieved by implementing isotropic sequence order learning and a third factor (ISO-3) that triggers learning at relevant moments. This third factor is modeled by phasic and tonic dopaminergic activity which respectively enable long-term potentiation to occur during acquisition, and long-term depression (LTD) to occur when adjustments in learned behaviors are required. It will be shown how the nucleus accumbens core uses conditioned reinforcers to invigorate instrumental responding while relatively strong LTD in the shell influences the core through a shell-ventral pallido-mediodorsal pathway. This pathway functions as a feed-forward switching mechanism and enables behavioral flexibility.
Why Forward Viral Fashion Messages? The Moderating Roles of Consumers’ Fashion Traits and Message Orientation

ABSTRACT Businesses are now using social media as platforms for viral marketing. However, little is known about the motivations, attitudes, and behaviors of fashion consumers who engage with this marketing instrument. This study examines the factors that influence consumers’ use of social media and their behavioral intentions to forward viral fashion messages. An attitudinal model was proposed through the integration of uses and gratification theory and the elaboration likelihood model. Individuals’ fashion trait and message orientations were specified as moderating factors. An online survey was administered to collect data, and 381 college students participated in the study. Hypotheses were tested using structural equation modeling. Findings showed that individuals’ intention to forward a message was affected by favorable functional and expressive attitudes towards the message, while motivations of using social media had only slight effects on individuals’ attitudes. Group comparisons showed significant moderating effects from identified individuals’ fashion trait and message orientation.
Origin of Late Precambrian Intrusive Carbonates , Eastern Desert of Egypt and Sudan : C , 0 and Sr Isotopic Evidence

Stern, R.J. and Gwinn, C.J., 1990. Origin of late Precambrian intrusive carbonates, Eastern Desert of Egypt and Sudan: C, 0 and Sr isotopic evidence. Precambrian Res., 46: 259-272. The problem of the origin of northeast African basement carbonates is approached using a regional study of C, 0 and Sr isotopic compositions in whole-rock samples of late Precambrian carbonate rocks of the Egyptian and Sudanese shields (ESS), from the Eastern Desert of Egypt and Sudan. The isotopic data indicate that three distinct reservoirs were available for generation of ESS intrusive carbonates: (1) sedimentary carbonates, with moderately high 87Sr/ 86Sr and heavy C and O; (2) depleted mantle, with low 87Sr/S6Sr and light C and O; and (3) enriched mantle or lower crust, with high 87Sr/S6Sr and light C and O. Isotopic data indicate that the intrusive carbonates of the North Eastern Desert were derived from reservoir (2), and a sample from the interior of Sudan was derived from reservoir (3). The origin of the remaining intrusive carbonates of the Central Eastern Desert and Sudan is best explained as mixing between remobilized sedimentary carbonates and mantle fluids, i.e. reservoirs (1) and (2). The source of the sedimentary carbonates may have been carbonate bank sediments deposited during Pan-African rifting and evolution of a passive continental margin on the north flank of the South Eastern Desert, now structurally buried under the Central Eastern Desert melange.
Appraisal models of intercultural communication apprehension among sojourners

ABSTRACT We used R. S. Lazarus’ (Emotion and Adaptation. Oxford: Oxford University Press, 1991) appraisal theory of emotions to propose a theoretical model of anxiety, upon which we built two empirical models centering on intercultural communication apprehension (ICA), distinguished by timing. We tested the models in three samples: Chinese in the US (N = 268), US Americans who studied abroad (N = 419), and US Americans in the US (N = 515). The models achieved good fit. The results showed that during an anticipated or actual intercultural interaction, people had multiple, potentially conflicting goals. The goal-related appraisals of the situation resulted in emotional reactions, such as ICA, as well as coping strategies. ICA and coping further influenced people’s immediacy behaviors and the intention to interact. Our empirical models supported the utility of the theoretical framework for all three samples, and provided advice for practitioners to improve sojourners’ time abroad.
Variations on the Common Subexpression Problem

Let G be a directed graph such that for each vertex v in G, the successors of v are ordered Let C be any equivalence relation on the vertices of G. The congruence closure C* of C is the finest equivalence relation containing C and such that any two vertices having corresponding successors equivalent under C* are themselves equivalent under C* Efficient algorithms are described for computing congruence closures in the general case and in the following two special cases. 0) G under C* is acyclic, and (it) G is acychc and C identifies a single pair of vertices. The use of these algorithms to test expression eqmvalence (a problem central to program verification) and to test losslessness of joins in relational databases is described