Miracle-dz/UniFAR-FTUs huggingface dataset:
Organisation for Economic Co-operation and Development 2003 Organisation De Coopération Et De Développement Economiques Working Party on Global and Structural Policies Oecd Workshop on the Benefits of Climate Policy: Improving Information for Policy Makers Abrupt Non-linear Climate Change, Irreversi

Project is to outline a conceptual framework to estimate the benefits of climate change policies, and to help organise information on this topic for policy makers. The Workshop covered both adaptation and mitigation policies, and related to different spatial and temporal scales for decision-making. However, particular emphasis was placed on understanding global benefits at different levels of mitigation-in other words, on the incremental benefit of going from one level of climate change to another. Participants were also asked to identify gaps in existing information and to recommend areas for improvement, including topics requiring further policy-related research and testing. The Workshop brought representatives from governments together with researchers from a range of disciplines to address these issues. Further background on the workshop, its agenda and participants, can be found on the internet at: The overall Project is overseen by the OECD Working Party on Global and Structural Policy (Environment Policy Committee). The Secretariat would like to thank the governments of Canada, Germany and the United States for providing extra-budgetary financial support for the work. This paper is issued as an authored " working paper "-one of a series emerging from the Project. The ideas expressed in the paper are those of the author alone and do not necessarily represent the views of the OECD or its Member Countries. As a working paper, this document has received only limited peer review. Some authors will be further refining their papers, either to eventually appear in the peer-reviewed academic literature, or to become part of a forthcoming OECD publication on this Project. The objective of placing these papers on the internet at this stage is to widely disseminate the ideas contained in them, with a view toward facilitating the review process.
A Self-Supervised Terrain Roughness Estimator for Off-Road Autonomous Driving

We present a machine learning approach for estimating the second derivative of a drivable surface, its roughness. Robot perception generally focuses on the first derivative, obstacle detection. However, the second derivative is also important due to its direct relation (with speed) to the shock the vehicle experiences. Knowing the second derivative allows a vehicle to slow down in advance of rough terrain. Estimating the second derivative is challenging due to uncertainty. For example, at range, laser readings may be so sparse that significant information about the surface is missing. Also, a high degree of precision is required in projecting laser readings. This precision may be unavailable due to latency or error in the pose estimation. We model these sources of error as a multivariate polynomial. Its coefficients are learned using the shock data as ground truth -- the accelerometers are used to train the lasers. The resulting classifier operates on individual laser readings from a road surface described by a 3D point cloud. The classifier identifies sections of road where the second derivative is likely to be large. Thus, the vehicle can slow down in advance, reducing the shock it experiences. The algorithm is an evolution of one we used in the 2005 DARPA Grand Challenge. We analyze it using data from that route.
Keratinocyte Growth Factor Induces Gene Expression Signature Associated with Suppression of Malignant Phenotype of Cutaneous Squamous Carcinoma Cells

Keratinocyte growth factor (KGF, fibroblast growth factor-7) is a fibroblast-derived mitogen, which stimulates proliferation of epithelial cells. The expression of KGF by dermal fibroblasts is induced following injury and it promotes wound repair. However, the role of KGF in cutaneous carcinogenesis and cancer progression is not known. We have examined the role of KGF in progression of squamous cell carcinoma (SCC) of the skin. The expression of KGF receptor (KGFR) mRNA was lower in cutaneous SCCs (n = 6) than in normal skin samples (n = 6). Expression of KGFR mRNA was detected in 6 out of 8 cutaneous SCC cell lines and the levels were downregulated by 24-h treatment with KGF. KGF did not stimulate SCC cell proliferation, but it reduced invasion of SCC cells through collagen. Gene expression profiling of three cutaneous SCC cell lines treated with KGF for 24 h revealed a specific gene expression signature characterized by upregulation of a set of genes specifically downregulated in SCC cells compared to normal epidermal keratinocytes, including genes with tumor suppressing properties (SPRY4, DUSP4, DUSP6, LRIG1, PHLDA1). KGF also induced downregulation of a set of genes specifically upregulated in SCC cells compared to normal keratinocytes, including genes associated with tumor progression (MMP13, MATN2, CXCL10, and IGFBP3). Downregulation of MMP-13 and KGFR expression in SCC cells and HaCaT cells was mediated via ERK1/2. Activation of ERK1/2 in HaCaT cells and tumorigenic Ha-ras-transformed HaCaT cells resulted in downregulation of MMP-13 and KGFR expression. These results provide evidence, that KGF does not promote progression of cutaneous SCC, but rather suppresses the malignant phenotype of cutaneous SCC cells by regulating the expression of several genes differentially expressed in SCC cells, as compared to normal keratinocytes.
Southern Hemisphere Origins for Interannual Variations of Snow Cover over the Western Tibetan Plateau in Boreal Summer

The climate response to the Tibetan Plateau (TP) snow cover (TPSC) has been receiving extensive concern. However, relatively few studies have been devoted to revealing the potential factors that can contribute to the TPSC interannual variability, especially during boreal summer. This study finds that the May Southern Hemisphere (SH) annular mode (SAM), the dominating mode of atmospheric circulation variability in the SH extratropics, exhibits a significant positive relationship with the interannual variations in western TPSC during boreal summer. Observational analysis and numerical experiments manifest that the signal of the May SAM can be “prolonged” by a meridional Indian Ocean tripole (IOT) sea surface temperature anomaly (SSTA) via atmosphere–ocean interaction. The IOT SSTA pattern persists into the following summer and excites anomalous local-scale zonal–vertical circulation. Subsequently, a tropical dipole rainfall (TDR) mode is induced with precipitation anomalies between the tropical western Indian Ocean and the eastern Indian Ocean–Maritime Continent. Rossby wave ray tracing diagnosis reveals that the wave energies, generated by the latent heat release of the TDR mode, can propagate northward into the western TP. As a response, abnormal cyclone (or anticyclone) and upward (or downward) movement are triggered over the western TP, providing favorable dynamical conditions for more (or less) TPSC. Moreover, the strong May SAM is usually followed by a cold air temperature anomaly over the western TP in summer, which is unfavorable for snow-cover melting, and vice versa. In brief, the IOT SSTA plays an “ocean bridge” role and the TDR mode plays an “atmosphere bridge” role in the process of the May SAM impacting the following summer TPSC variability. The results may provide new insight into the cross-equatorial propagation of the SAM influence.
Ventral striatal dopamine synthesis capacity is associated with individual differences in behavioral disinhibition

Pathological gambling, alongside addictive and antisocial disorders, forms part of a broad psychopathological spectrum of externalizing disorders, which share an underlying genetic vulnerability. The shared externalizing propensity is a highly heritable, continuously varying trait. Disinhibitory personality traits such as impulsivity and novelty seeking (NS) function as indicators of this broad shared externalizing tendency, which may reflect, at the neurobiological level, variation in the reactivity of dopaminergic (DAergic) brain reward systems centered on the ventral striatum (VS). Here, we examined whether individual differences in ventral striatal dopamine (DA) synthesis capacity were associated with individual variation in disinhibitory personality traits. Twelve healthy male volunteers underwent 6-[18F]Fluoro-L-DOPA (FDOPA) positron emission tomography (PET) scanning to measure striatal DA synthesis capacity, and completed a measure of disinhibited personality (NS). We found that levels of ventral, but not dorsal, striatal DA synthesis capacity were significantly correlated with inter-individual variation in disinhibitory personality traits, particularly a propensity for financial extravagance and irresponsibility. Our results are consistent with preclinical models of behavioral disinhibition and addiction proneness, and provide novel insights into the neurobiology of personality based vulnerability to pathological gambling and other externalizing disorders.
Voltage Clamp Fluorimetry Reveals a Novel Outer Pore Instability in a Mammalian Voltage-gated Potassium Channel

Voltage-gated potassium (Kv) channel gating involves complex structural rearrangements that regulate the ability of channels to conduct K+ ions. Fluorescence-based approaches provide a powerful technique to directly report structural dynamics underlying these gating processes in Shaker Kv channels. Here, we apply voltage clamp fluorimetry, for the first time, to study voltage sensor motions in mammalian Kv1.5 channels. Despite the homology between Kv1.5 and the Shaker channel, attaching TMRM or PyMPO fluorescent probes to substituted cysteine residues in the S3–S4 linker of Kv1.5 (M394C-V401C) revealed unique and unusual fluorescence signals. Whereas the fluorescence during voltage sensor movement in Shaker channels was monoexponential and occurred with a similar time course to ionic current activation, the fluorescence report of Kv1.5 voltage sensor motions was transient with a prominent rapidly dequenching component that, with TMRM at A397C (equivalent to Shaker A359C), represented 36 ± 3% of the total signal and occurred with a τ of 3.4 ± 0.6 ms at +60 mV (n = 4). Using a number of approaches, including 4-AP drug block and the ILT triple mutation, which dissociate channel opening from voltage sensor movement, we demonstrate that the unique dequenching component of fluorescence is associated with channel opening. By regulating the outer pore structure using raised (99 mM) external K+ to stabilize the conducting configuration of the selectivity filter, or the mutations W472F (equivalent to Shaker W434F) and H463G to stabilize the nonconducting (P-type inactivated) configuration of the selectivity filter, we show that the dequenching of fluorescence reflects rapid structural events at the selectivity filter gate rather than the intracellular pore gate.
A Splicing Mutation in the Novel Mitochondrial Protein DNAJC11 Causes Motor Neuron Pathology Associated with Cristae Disorganization, and Lymphoid Abnormalities in Mice

Mitochondrial structure and function is emerging as a major contributor to neuromuscular disease, highlighting the need for the complete elucidation of the underlying molecular and pathophysiological mechanisms. Following a forward genetics approach with N-ethyl-N-nitrosourea (ENU)-mediated random mutagenesis, we identified a novel mouse model of autosomal recessive neuromuscular disease caused by a splice-site hypomorphic mutation in a novel gene of unknown function, DnaJC11. Recent findings have demonstrated that DNAJC11 protein co-immunoprecipitates with proteins of the mitochondrial contact site (MICOS) complex involved in the formation of mitochondrial cristae and cristae junctions. Homozygous mutant mice developed locomotion defects, muscle weakness, spasticity, limb tremor, leucopenia, thymic and splenic hypoplasia, general wasting and early lethality. Neuropathological analysis showed severe vacuolation of the motor neurons in the spinal cord, originating from dilatations of the endoplasmic reticulum and notably from mitochondria that had lost their proper inner membrane organization. The causal role of the identified mutation in DnaJC11 was verified in rescue experiments by overexpressing the human ortholog. The full length 63 kDa isoform of human DNAJC11 was shown to localize in the periphery of the mitochondrial outer membrane whereas putative additional isoforms displayed differential submitochondrial localization. Moreover, we showed that DNAJC11 is assembled in a high molecular weight complex, similarly to mitofilin and that downregulation of mitofilin or SAM50 affected the levels of DNAJC11 in HeLa cells. Our findings provide the first mouse mutant for a putative MICOS protein and establish a link between DNAJC11 and neuromuscular diseases.
Impact of fairness on Internet performance

We discuss the relevance of fairness as a design objective for congestion control mechanisms in the Internet. Specifically, we consider a backbone network shared by a dynamic number of short-lived flows, and study the impact of bandwidth sharing on network performance. In particular, we prove that for a broad class of fair bandwidth allocations, the total number of flows in progress remains finite if the load of every link is less than one. We also show that provided the bandwidth allocation is "sufficiently" fair, performance is optimal in the sense that the throughput of the flows is mainly determined by their access rate. Neither property is guaranteed with unfair bandwidth allocations, when priority is given to one class of flow with respect to another. This suggests current proposals for a differentiated services Internet may lead to suboptimal utilization of network resources.
Status of research in vascular access for dialysis.

BACKGROUND Vascular access issues impose a major financial burden to health care and can be associated with increased morbidity and mortality. In this context, strategies, guidelines and available published information become important tools for health-care facilities and workers. While published data form a sound basis of formulating clinical practice guidelines for vascular access (VA), quality of the medical information is critically important. This study investigates the current status of VA publications. METHODS A PubMed search was performed to capture all articles related to dialysis vascular access published from January 1997 to December 2009. The articles were categorized by publication type, study subject, year of publication and specialty of the authors. RESULTS A total of 2260 articles from 60 medical journals were identified. Insignificant publications (letters/communications, n = 125) were excluded from the analysis. Therefore, 2135 articles formed the basis for analysis. Sixteen of the 60 journals routinely published on vascular access and generated 1747 articles [nephrology = 7 (publications = 782); radiology = 4 (publications = 333); surgery = 5 (publications = 486)], while 44/60 journals published scarcely and produced 388 articles over the 13-year period. Overall, 1213 (57%) of the articles were published by the direct involvement of nephrologists [nephrologists alone (n = 564); nephrologists in collaboration with others (n = 649)]. There were 1194 observational studies, 444 case reports/series, 375 review/editorials, 51 basic research, 12 meta-analyses and 59 randomized controlled trials published over the 13-year period. The average impact factor for nephrology, radiology and surgery journals that routinely published on vascular access was 4.425, 3.099 and 2.679, respectively. CONCLUSIONS Despite an increased rate of scholarly activity in the area of vascular access, there remains a significant challenge ahead due to the lack of randomized controlled trials and research focusing on the biology of vascular access stenosis.
Neural substrates for functionally discriminating self‐face from personally familiar faces

Understanding the neurobiological substrates of self‐recognition yields important insight into socially and clinically critical cognitive functions such as theory of mind. Experimental evidence suggests that right frontal and parietal lobes preferentially process self‐referent information. Recognition of one's own face is an important parameter of self‐recognition, but well‐controlled experimental data on the brain substrates of self‐face recognition is limited. The goal of this study was to characterize the activation specific to self‐face in comparison with control conditions of two levels of familiarity: unknown unfamiliar face and the more stringent control of a personally familiar face. We studied 12 healthy volunteers who made “unknown,” “familiar,” and “self” judgments about photographs of three types of faces: six different novel faces, a personally familiar face (participant's fraternity brother), and their own face during an event‐related functional MRI (fMRI) experiment. Contrasting unknown faces with baseline showed activation of the inferior occipital lobe, which supports previous findings suggesting the presence of a generalized face‐processing area within the inferior occipital‐temporal region. Activation in response to a familiar face, when contrasted with an unknown face, invoked insula, middle temporal, inferior parietal, and medial frontal lobe activation, which is consistent with an existing hypothesis suggesting familiar face recognition taps neural substrates that are different from those involved in general facial processing. Brain response to self‐face, when contrasted with familiar face, revealed activation in the right superior frontal gyrus, medial frontal and inferior parietal lobes, and left middle temporal gyrus. The contrast familiar vs. self produced activation only in the anterior cingulate gyrus. Our results support the existence of a bilateral network for both perceptual and executive aspects of self‐face processing that cannot be accounted for by a simple hemispheric dominance model. This network is similar to those implicated in social cognition, mirror neuron matching, and face‐name matching. Our findings also show that some regions of the medial frontal and parietal lobes are specifically activated by familiar faces but not unknown or self‐faces, indicating that these regions may serve as markers of face familiarity and that the differences between activation associated with self‐face recognition and familiar face recognition are subtle and appear to be localized to lateral frontal, parietal, and temporal regions. Hum. Brain Mapping, 2005. © 2005 Wiley‐Liss, Inc.
Utility of Washington Early Recognition Center Self-Report Screening Questionnaires in the Assessment of Patients with Schizophrenia and Bipolar Disorder

Early identification and treatment are associated with improved outcomes in bipolar disorder (BPD) and schizophrenia (SCZ). Screening for the presence of these disorders usually involves time-intensive interviews that may not be practical in settings where mental health providers are limited. Thus, individuals at earlier stages of illness are often not identified. The Washington Early Recognition Center Affectivity and Psychosis (WERCAP) screen is a self-report questionnaire originally developed to identify clinical risk for developing bipolar or psychotic disorders. The goal of the current study was to investigate the utility of the WERCAP Screen and two complementary questionnaires, the WERC Stress Screen and the WERC Substance Screen, in identifying individuals with established SCZ or BPD. Participants consisted of 35 BPD and 34 SCZ patients, as well as 32 controls (CON), aged 18–30 years. Univariate analyses were used to test for score differences between groups. Logistic regression and receiver operating characteristic (ROC) curves were used to identify diagnostic predictors. Significant group differences were found for the psychosis section of the WERCAP (pWERCAP; p < 0.001), affective section of the WERCAP (aWERCAP; p = 0.001), and stress severity (p = 0.027). No significant group differences were found in the rates of substance use as measured by the WERC Substance Screen (p = 0.267). Only the aWERCAP and pWERCAP scores were useful predictors of diagnostic category. ROC curve analysis showed the optimal cut point on the aWERCAP to identify BPD among our participant groups was a score of >20 [area under the curve (AUC): 0.87; sensitivity: 0.91; specificity: 0.71], while that for the pWERCAP to identify SCZ was a score of >13 (AUC: 0.89; sensitivity: 0.88; specificity: 0.82). These results indicate that the WERCAP Screen may be useful in screening individuals for BPD and SCZ and that identifying stress and substance-use severity can be rapidly done using self-report questionnaires. Larger studies in undiagnosed individuals will be needed to test the WERCAP Screen’s ability to identify mania or psychosis in the community.
Effect of phosphorus and biofertilizers on growth, yield and nutrient uptake of long duration pigeonpea under rainfed condition

Field experiments were conducted in Varanasi, Uttar Pradesh, India, during the 2004-05 and 2005-06 rainy seasons, to study the effect of phosphorus (P) fertilizer levels (0, 15, 30, 45 and 60 kg P2O5/ha) and biofertilizers (untreated control, Rhizobium, PSB and Rhizobium + PSB) on growth, yield and nutrient uptake of long duration pigeon pea. The results showed that the application of 60 kg P2O5/ha being at par with 45 kg P2O5/ha recorded the maximum plant height (203.0 cm), number of primary branches (20.8), dry matter per plant (159.6 g), grain yield (2260 kg/ha), stalk yield (8020 kg/ha) and uptake of N (112.3 kg/ha) and P (18.9 kg/ha). Among the biofertilizers, Rhizobium+PSB produced significantly taller plants (198.7 cm), maximum number of branches per plant (18.9), dry matter per plant (156.4 g), grain yield (2060 kg/ha), stalk yield (7560 kg/ha) and uptake of N (104.9 kg/ha) and P (16.9 kg/ha) than other biofertilizers treatments. The combined effect of 60 kg P + Rhizobium + PSB produced significantly higher dry matter (165.8 g/plant), grain yield (2510 kg/ha) and P uptake (21.4 kg/ha) than other combinations, except 45 kg P2O5 + Rhizobium + PSB. Maximum net returns (Rs. 40 005) was obtained with 60 kg P2O5 + Rhizobium + PSB, followed by 45 kg P2O5 + Rhizobium + PSB (Rs. 38 920)
The Expression of Petunia Strigolactone Pathway Genes is Altered as Part of the Endogenous Developmental Program

Analysis of mutants with increased branching has revealed the strigolactone synthesis/perception pathway which regulates branching in plants. However, whether variation in this well conserved developmental signaling system contributes to the unique plant architectures of different species is yet to be determined. We examined petunia orthologs of the Arabidopsis MAX1 and MAX2 genes to characterize their role in petunia architecture. A single ortholog of MAX1, PhMAX1 which encodes a cytochrome P450, was identified and was able to complement the max1 mutant of Arabidopsis. Petunia has two copies of the MAX2 gene, PhMAX2A and PhMAX2B which encode F-Box proteins. Differences in the transcript levels of these two MAX2-like genes suggest diverging functions. Unlike PhMAX2B, PhMAX2A mRNA levels change in leaves of differing age/position on the plant. Nonetheless, this gene functionally complements the Arabidopsis max2 mutant indicating that the biochemical activity of the PhMAX2A protein is not significantly different from MAX2. The expression of the petunia strigolactone pathway genes (PhCCD7, PhCCD8, PhMAX1, PhMAX2A, and PhMAX2B) was then further investigated throughout the development of wild-type petunia plants. Three of these genes showed changes in mRNA levels over a development series. Alterations to the expression patterns of these genes may influence the branching growth habit of plants by changing strigolactone production and/or sensitivity. These changes could allow both subtle and dramatic changes to branching within and between species.