Miracle-dz/UniFAR-FTUs huggingface dataset:
Home Foreclosure, Health, and Mental Health: A Systematic Review of Individual, Aggregate, and Contextual Associations

Background The U.S. foreclosure crisis intensified markedly during the Great Recession of 2007-09, and currently an estimated five percent of U.S. residential properties are more than 90 days past due or in the process of foreclosure. Yet there has been no systematic assessment of the effects of foreclosure on health and mental health. Methods and Findings I applied systematic search terms to PubMed and PsycINFO to identify quantitative or qualitative studies about the relationship between home foreclosure and health or mental health. After screening the titles and abstracts of 930 publications and reviewing the full text of 76 articles, dissertations, and other reports, I identified 42 publications representing 35 unique studies about foreclosure, health, and mental health. The majority of studies (32 [91%]) concluded that foreclosure had adverse effects on health or mental health, while three studies yielded null or mixed findings. Only two studies examined the extent to which foreclosure may have disproportionate impacts on ethnic or racial minority populations. Conclusions Home foreclosure adversely affects health and mental health through channels operating at multiple levels: at the individual level, the stress of personally experiencing foreclosure was associated with worsened mental health and adverse health behaviors, which were in turn linked to poorer health status; at the community level, increasing degradation of the neighborhood environment had indirect, cross-level adverse effects on health and mental health. Early intervention may be able to prevent acute economic shocks from eventually developing into the chronic stress of foreclosure, with all of the attendant benefits this implies for health and mental health status. Programs designed to encourage early return of foreclosed properties back into productive use may have similar health and mental health benefits.
Impact of license choice on Open Source Software development activity

The Open Source Software (OSS) development model has emerged as an important competing paradigm to proprietary alternatives; however, insufficient research exists to understand the influence of some OSS project characteristics on the level of activity of the development process. A basic such characteristic is the selection of the project's software license. Drawing upon social movement theory, our study examined the relationship between OSS licenses and project activity. Some OSS licenses include a “copyleft” clause, which requires that if derivative products are to be released, it must be done under the license the original product had. We hypothesize that copylefted licenses, as opposed to noncopylefted licenses, are associated with higher developer membership and coding activity, faster development speed, and longer developer permanence in the project. To test the hypotheses, we used archival data sources of working OSS projects spanning several years of development time. We discuss practical and theoretical implications of the results as well as future research ideas. © 2009 Wiley Periodicals, Inc.
CaMKIIβ is localized in dendritic spines as both drebrin‐dependent and drebrin‐independent pools

Drebrin is a major F‐actin binding protein in dendritic spines that is critically involved in the regulation of dendritic spine morphogenesis, pathology, and plasticity. In this study, we aimed to identify a novel drebrin‐binding protein involved in spine morphogenesis and synaptic plasticity. We confirmed the beta subunit of Ca2+/calmodulin‐dependent protein kinase II (CaMKIIβ) as a drebrin‐binding protein using a yeast two‐hybrid system, and investigated the drebrin–CaMKIIβ relationship in dendritic spines using rat hippocampal neurons. Drebrin knockdown resulted in diffuse localization of CaMKIIβ in dendrites during the resting state, suggesting that drebrin is involved in the accumulation of CaMKIIβ in dendritic spines. Fluorescence recovery after photobleaching analysis showed that drebrin knockdown increased the stable fraction of CaMKIIβ, indicating the presence of drebrin‐independent, more stable CaMKIIβ. NMDA receptor activation also increased the stable fraction in parallel with drebrin exodus from dendritic spines. These findings suggest that CaMKIIβ can be classified into distinct pools: CaMKIIβ associated with drebrin, CaMKIIβ associated with post‐synaptic density (PSD), and CaMKIIβ free from PSD and drebrin. CaMKIIβ appears to be anchored to a protein complex composed of drebrin‐binding F‐actin during the resting state. NMDA receptor activation releases CaMKIIβ from drebrin resulting in CaMKIIβ association with PSD.
Antibiotic interceptors: Creating safe spaces for bacteria

Antibiotics have underpinned numerous advances including surgery, organ transplantation, and cancer chemotherapy. Therefore, the emergence of bacterial pathogens that are resistant to therapeutic antibiotics poses enormous challenges to modern medicine [1]. One of the key mechanisms by which bacteria resist antibiotics is the production of enzymes that inactivate antibacterial molecules via hydrolysis or chemical modification [1]. However, there is growing evidence that bacteria can also survive exposure to antibiotics by releasing molecules into the extracellular space that sequester the drug and prevent it from reaching its target. Some of these ‘antibiotic interceptors’ function as decoys by mimicking target molecules, whilst others share no obvious similarity to the target at all (Fig 1). Many interceptors also function as structural components of biofilms, thereby contributing to the antibiotic tolerance of these bacterial communities. This article summarises our current understanding of antibiotic interceptors, explores the selection pressures for the emergence of these systems, and identifies future research avenues to characterise and overcome antimicrobial interception strategies.
The importance of the Logistics Performance Index in international trade

Logistics and transport increasingly play a pivotal role in international trade relations. The Logistics Performance Index (LPI) analyses differences between countries in terms of customs procedures, logistics costs and the quality of the infrastructure for overland and maritime transport. The aim of this article is to analyse the impact that each of these components has on trade in emerging economies using a gravity model. Furthermore, the study also attempts to detect possible advances in logistics in developing countries, which are grouped into five regions (Africa, South America, Far East, Middle East and Eastern Europe) by comparing the first LPI data published in 2007 with the most recent data, released in 2012. The results obtained reveal that improvements in any of the components of the LPI can lead to significant growth in a country’s trade flows. Specifically, LPI components are becoming increasingly important for international trade in many countries in Africa, South America and Eastern Europe.
Limited evidence of interactive disturbance and nutrient effects on the diversity of macrobenthic assemblages.

The causes and consequences of the coexistence of a number of species in a given habitat have attracted ecological research for several decades. Numerous theories have been developed in this context, including the ‘intermediate disturbance hypothesis’ (IDH), but supportive experimental evidence remains scarce and contradictory, leading scientists to propose the existence of an interaction between disturbance and productivity. This study assessed the interactive effects of disturbance and nutrient enrichment at 1 oligotrophic (Arraial do Cabo) and 1 eutrophic (Guanabara Bay) site on the coast of Brazil. At each site, an epibenthic assemblage was allowed to establish on settlement panels (PVC) for 3 mo prior to a 6 mo manipulation phase comprising nutrient enrichment and disturbance (biomass removal). Our results revealed site-specific diversity-driving processes in the absence of disturbance. Nevertheless, diversity and species richness peaked at both sites at some intermediate level of disturbance, corroborating the IDH. Nutrient enrichment increased total species richness and algal species richness in particular, but only at the oligotrophic site. Only here, did nutrient enrichment eliminate the unimodal species richness pattern observed along the disturbance gradient under ambient nutrient concentrations. Such interactive effects of disturbance and productivity on diversity confirm the general predictions of advanced IDH models, e.g. the Kondoh model. The present study indicates that interactive effects of ‘bottom-up’ and ‘top-down’ processes may explain more of the variation in community diversity than the separate models of disturbance–diversity and productivity–diversity relationships.
High‐resolution imaging mass spectrometry reveals detailed spatial distribution of phosphatidylinositols in human breast cancer

High‐resolution matrix‐assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is an emerging application for lipid research that provides a comprehensive and detailed spatial distribution of ionized molecules. Recent lipidomic approach has identified several phospholipids and phosphatidylinositols (PIs) are accumulated in breast cancer tissues and are therefore novel biomarker candidates. Because their distribution and significance remain unclear, we investigated the precise spatial distribution of PIs in human breast cancer tissues using high‐resolution MALDI IMS. We evaluated tissues from nine human breast cancers and one normal mammary gland by negative ion MALDI IMS at a resolution of 10 μm. We detected 10 PIs with different fatty acid compositions, and their proportions were remarkably variable in the malignant epithelial regions. High‐resolution imaging enabled us to discriminate cancer cell clusters from the adjacent stromal tissue within epithelial regions; moreover, this technique revealed that several PIs were specifically localized to cancer cell clusters. These PIs were heterogeneously distributed within cancer cell clusters, allowing us to identify two different populations of cancer cells that predominantly expressed either PI(18:0/18:1) or PI(18:0/20:3). Tracing the expression level of PIs during cancer cell progression suggested that the latter population is associated with the invasion. Our study documents a novel model for phospholipid analysis of breast cancer tissues by using high‐resolution MALDI IMS and identifies candidate PIs that can describe a specific phenotype of cancer cells.
Monthly variations in aneurysmal subarachnoid hemorrhage incidence and mortality: Correlation with weather and pollution

Background and purpose Although the effect of weather and air pollution on the occurrence of subarachnoid hemorrhage (SAH) has been investigated, results have remained inconsistent. The present study aimed to determine the seasonality of aneurysmal subarachnoid hemorrhage occurrence and mortality. Methods We used the National Inpatient Sample database to evaluate the effect of meteorological factors and air pollutants on patients with subarachnoid hemorrhage in Korea between 2011 and 2014. Monthly variations in SAH occurrence and mortality were analyzed using locally weighted scatter plot smoothing curves. Multivariate Poisson generalized linear regression models were used to evaluate potential independent meteorological and pollutant variables associated with SAH occurrence and mortality. Results In total, 21,407 patients who underwent clip or coil treatment owing to aneurysmal SAH in Korea from January 1, 2011, to December 31, 2014, were included. The crude incidence rate of SAH in Korea was 10.5 per 100,000 people per year. An approximately 0.5% lower risk of SAH was observed per 1°C increase in mean monthly temperature (relative risk, 0.995; 95% confidence interval [CI], 0.992–0.997; p < 0.001), while an approximately 2.3% higher risk of SAH was observed per 1°C increase in mean monthly diurnal temperature. Conclusions We showed distinct patterns of seasonal and monthly variation in the occurrence and mortality of SAH. Our findings suggest that meteorological factors may play an important role in monthly variations in the occurrence of aneurysmal SAH.
CORRELATED RESPONSES TO SELECTION FOR FASTER DEVELOPMENT AND EARLY REPRODUCTION IN DROSOPHILA: THE EVOLUTION OF LARVAL TRAITS

Abstract Studies on selection for faster development in Drosophila have typically focused on the trade-offs among development time, adult weight, and adult life span. Relatively less attention has been paid to the evolution of preadult life stages and behaviors in response to such selection. We have earlier reported that four laboratory populations of D. melanogaster selected for faster development and early reproduction, relative to control populations, showed considerably reduced preadult development time and survivorship, dry weight at eclosion, and larval growth rates. Here we study the larval phase of these populations in greater detail. We show here that the reduction in development time after about 50 generations of selection is due to reduced duration of the first and third larval instars and the pupal stage, whereas the duration of the second larval instar has not changed. About 90% of the preadult mortality in the selected populations is due to larval mortality. The third instar larvae, pupae, and freshly eclosed adults of the selected populations weigh significantly less than controls, and this difference appears during the third larval instar. Thereafter, percentage weight loss during the pupal stage does not differ between selected and control populations. The minimum amount of time a larva must feed to subsequently complete development is lower in the selected populations, which also exhibit a syndrome of reduced energy expenditure through reduction in larval feeding rate, larval digging and foraging activity, and pupation height. Comparison of these results with those observed earlier in populations selected for adaptation to larval crowding and faster development under a different protocol from ours reveal differences in the evolved traits that suggest that the responses to selection for faster development are greatly affected by the larval density at which selection acts and on details of the selection pressures acting on the timing of reproduction. Corresponding Editor: C. López-Fanjul
Accuracy of Diagnostic Antibody Tests for Coeliac Disease in Children: Summary of an Evidence Report

Objective: The aim of this study was to summarise the evidence from 2004 to September 2009 on the performance of laboratory-based serological and point of care (POC) tests for diagnosing coeliac disease (CD) in children using histology as reference standard. Patients and Methods: We searched MEDLINE and EMBASE for studies reporting on children for tests based on IgA and IgG anti-gliadin (AGA), endomysial (EmA), anti-transglutaminase-2 (TG2), and anti-deamidated gliadin peptides (DGP) antibodies or POC tests. For inclusion, histological analysis of duodenal biopsies and sensitivity and specificity for index tests had to be reported. Data were pooled and summary measures calculated for sensitivity, specificity, positive and negative likelihood ratios (“LR+”, “LR−”), and diagnostic odds ratios (DOR). In case of elevated statistical heterogeneity, studies reaching 90% sensitivity or specificity were reported. Results: A total of 2510 articles were reviewed; 16 entered meta-analysis, reporting on 3110 patients (1876 with CD, 1234 without CD). For IgA-EmA, sensitivity was ≥90% in 7/11 studies and pooled specificity 98.2%. For IgA-anti-TG2, 11/15 studies yielded sensitivities ≥90% and 13/15 specificities ≥90%. For IgA-DGP, sensitivity ranged between 80.7% and 95.1% (specificity 86.3%–93.1%); for IgG-DGP between 80.1% and 98.6% (specificity 86.0–96.9%). IgA-EmA had the highest pooled DOR (554) and LR+ (31.8) for a laboratory test, followed by IgA-anti-TG2, IgG-DGP, IgA-DGP and IgA-AGA. POC tests showed a pooled sensitivity of 96.4% for IgA-TG2 (specificity 97.7%). Conclusions: IgA-EmA and IgA-anti-TG2 tests appear highly accurate to diagnose CD. IgG-anti-DGP tests may help in excluding CD. IgA-AGA and IgA-DGP tests show inferior accuracy. POC tests may achieve high accuracy in the hands of experienced readers, but IgA-anti-TG2/EmA were superior.
The Bulk of the Cosmic Infrared Background Resolved by ISOCAM

Deep extragalactic surveys with ISOCAM revealed the presence of a large density of faint mid-infrared (MIR) sources. We have computed the 15m integrated galaxy light produced by these galaxies above a sensitivity limit of 50 Jy. It sets a lower limit to the 15m extragalactic background light of (2:4 0:5) nW m 2 sr 1 . T he redshift distribution of the ISOCAM galaxies is inferred from the spectroscopically complete sample of galaxies in the Hubble Deep Field North (HDFN). It peaks around z 0.8 in agreement with studies in other elds. The rest-frame 15m and bolometric infrared (8{1000m) luminosities of ISOCAM galaxies are computed using the correlations that we establish between the 6.75, 12, 15m and infrared (IR) luminosities of local galaxies. The resulting IR luminosities were double-checked using radio (1.4 GHz) flux densities from the ultra-deep VLA and WSRT surveys of the HDFN on a sample of 24 galaxies as well as on a sample of 109 local galaxies in common between ISOCAM and the NRAO VLA Sky Survey (NVSS). This comparison shows for the rst time that MIR and radio luminosities correlate up to z 1. This result validates the bolometric IR luminosities derived from MIR luminosities unless both the radio-far infrared (FIR) and the MIR-FIR correlations become invalid around z 1. The fraction of IR light produced by active nuclei was computed from the cross-correlation with the deepest X-ray surveys from the Chandra and XMM-Newton observatories in the HDFN and Lockman Hole respectively. We nd that at most 20% of the 15m integrated galaxy light is due to active galactic nuclei (AGNs) unless a large population of AGNs was missed by Chandra and XMM-Newton. About 75% of the ISOCAM galaxies are found to belong to the class of luminous infrared galaxies (LIR 10 11 L). They exhibit star formation rates of the order of100 M yr 1 . The comoving density of infrared light due to these luminous IR galaxies was more than 40 times larger at z 1 than today. The contribution of ISOCAM galaxies to the peak of the cosmic infrared background (CIRB) at 140m was computed from the MIR-FIR correlations for star forming galaxies and from the spectral energy distribution of the Seyfert 2, NGC 1068, for AGNs. We nd that the galaxies unveiled by ISOCAM surveys are responsible for the bulk of the CIRB, i.e. (16 5) nW m 2 sr 1 as compared to the (25 7) nW m 2 sr 1 measured with the COBE satellite, with less than 10% due to AGNs. Since the CIRB contains most of the light radiated over the history of star formation in the universe, this means that a large fraction of present-day stars must have formed during a dusty starburst event similar to those revealed by ISOCAM.
Aryl hydrocarbon receptor gene transitions ( c .-742 C > T ; c . 1661 G > A ) and idiopathic male infertility : a case-control study with in silico and meta-analysis

Aryl hydrocarbon receptor (AHR) is responsible for crucial events in male reproductive biology. Here, the association of the AHR transitions c. -742C>T and c.1661G>A with idiopathic male infertility was investigated in a casecontrol study, which is followed by a meta-analysis and a bioinformatic investigation. Blood and semen samples were obtained from a total of 135 idiopathic infertile men and 130 healthy controls. Participants were genotyped for the transitions using a PCR-RFLP method. A meta-analysis of five sets of data evaluated the association of c.1661G>A with male infertility, and using an in silico analysis, the possible molecular effects of the transitions predicted. Genotypes and alleles of AHR-c. -742C>Tand c.1661G>A polymorphisms were not associated with the risk of male infertility significantly. However, the frequency of C/A haplotype was significantly associated with the increased risk of male infertility, and T/A haplotype was higher among controls significantly. Also, the frequencies of combined genotypes CT/GG, CT/GA and TT/ GG were significantly associated with decreased risk of infertility. And, the meta-analysis showed that the AA versus GA/GG recessive model is associated with decreased risk of male infertility among the Iranian population. In silico analysis predicted that c. -742C>T does not alter the binding sites of the proposed transcription factors, but c.1661G>A poses a tolerable structural disturbance in AHR protein. In conclusion, these results showed that AHR c. -742C>T and c.1661G>A transitions separately could not be nominated as a risk or protective factor for male infertility. However, some combined models could affect infertility risk, especially among Iranian men.
The Relation of Intellectual Capital Disclosure Strategies and Market Value in Two Political Settings

Purpose – The purpose of this paper is to investigate whether the political setting (civil war versus temporary truce) in a country has an influence on firms' current narrative, visual, and numerical intellectual capital disclosure being included in the current market value of equity. Design/Methodology/Approach – Using content analysis for data generation, this study identifies narrative, visual, and numerical intellectual capital disclosure in firms' annual reports. Financial data were obtained from firms' annual reports and the stock exchange. Fixed effect panel regression was conducted separately for the civil war period and temporary truce period. Findings – The paper finds that during the period entirely beset by civil war, the current market value of equity includes net book value and current earnings only, and does not include narrative, visual, or numerical intellectual capital disclosure. During the period of temporary truce, the current market value of equity includes net book value, current earnings, and narrative disclosure, but not visual or numerical intellectual capital disclosure. Practical Implications – The findings provide insights into the effectiveness of disclosure strategies in politically unstable environments. Originality/Value – This study analyses the disclosure strategies in a civil war and temporary truce context.