Miracle-dz/UniFAR-FTUs huggingface dataset:
The reception of Anglo leadership styles in a transforming society: the case of American companies in Vietnam

This article examines the transfer of Anglo leadership styles in a transforming society. It aims to investigate the transferability of two American leadership styles, namely performance-oriented and participative styles, to Vietnamese subsidiaries. Utilising an exploratory case study approach, this article presents evidence of a strong acceptance of these leadership styles, and tries to ascertain whether the adoption of a humane style of leadership in line with Vietnamese traditions is a means of leaders reconciling the cultural gap. Several complexities arise from the transforming nature of the Vietnamese socio-political and economic context. Specifically, the importance of subcultures – particularly those relating to generation – is highlighted. Situational contingencies, such as the skills set of the recipient group, also emerge as important considerations. Finally, the authors call for leadership dynamism as a means of facilitating congruence and adaptability between the leadership styles used and the various contextual complexities encountered in the transfer and reception process.
A meta-analysis of deep hypothermic circulatory arrest versus moderate hypothermic circulatory arrest with selective antegrade cerebral perfusion.

INTRODUCTION A recent concern of deep hypothermic circulatory arrest (DHCA) in aortic arch surgery has been its potential association with increased risk of coagulopathy, elevated inflammatory response and end-organ dysfunction. Recently, moderate hypothermic circulatory arrest (MHCA) with selective antegrade circulatory arrest (SACP) seeks to negate potential hypothermia-related morbidities, while maintaining adequate neuroprotection. The present meta-analysis aims to compare postoperative outcomes in arch surgery using DHCA or MHCA+SACP as neuroprotective strategies. METHODS Electronic searches were performed using six databases from their inception to January 2013. Two reviewers independently identified all relevant studies comparing DHCA with MHCA+SACP, as defined by a recent hypothermia temperature consensus. Data were extracted and meta-analyzed according to pre-defined clinical endpoints. RESULTS Nine comparative studies were identified for inclusion in the present meta-analysis. Stroke rates were significantly lower in patients undergoing MHCA+SACP (P=0.0007, I(2)=0%), while comparable results were observed with temporary neurological deficit, mortality, renal failure or bleeding. Infrequent and inconsistent reporting of systemic outcomes precluded analysis of other systemic outcomes. CONCLUSIONS The present meta-analysis indicated the superiority of MHCA+SACP in terms of stroke risk.
Using developer conversations to resolve uncertainty in software development: a position paper

Software development is a social process: tasks such as implementing a requirement or fixing a bug typically spark conversations between the stakeholders of a software project, where they identify points of uncertainty in the solution space and explore proposals to resolve them. Due to the fluid nature of these interactions, it is hard for project managers to maintain an overall understanding of the state of the discussion and to know when and how to intervene. We propose an approach for extracting the uncertainty information from developer conversations in order to provide managers with analytics. Using these allows us to recommend specific actions that managers can take to better facilitate the resolution of uncertainty.
EVALUATING THE IMPACTS OF UNCERTAINTY IN GEOMORPHIC CHANNEL- CHANGES ON PREDICTING MERCURY TRANSPORT AND FATE IN THE CARSON RIVER SYSTEM, NEVADA

The Carson River is one of the most mercury-contaminated fluvial systems in North America. Most of its mercury is affiliated with channel bank material and floodplain deposits, with the movement of mercury through this system being highly dependent on bank erosion and sediment transport processes. Mercury transport is simulated using three computer models: RIVMOD, WASP5, and MERC4. Model improvements include the addition of a bank package that accounts for flow history. The rates at which river stages are rising or falling will, in turn, impart time-dependant and vertically variable MeHg concentrations within the channel banks along the Carson River. Also, Lahontan Reservoir’s geomorphic characteristics have been refined along with the explicit tracking of a temporally and spatially varying colloidal fraction. The augmented and refined modeling approach results in more accurate and realistic simulation of mercury transport and fate. An extensive uncertainty analysis, involving characterizing the co-variance of two calibration parameters used to define bank erosion and overbank deposition, will define the degree of expected variation in model predictions relative to limitations posed by available field data.
Privacy Concerns Amidst OBA and the Need for Alternative Models

What convinces users to share information about themselves in an ad-based online world? We explore users willingness to share data in the context of online behavioural advertising (OBA) and tracking prevention tools. We find positive responses for OBA and clear preferences for which types of information users would like to disclose. Factors including privacy attitudes and control mechanisms impact peoples decisions to share their information with websites. These factors yield a discussion of the ad-based business model of the Internet and the balance with user preferences.
The effect of prehydration on the engineering properties of CEM I Portland cement

Prehydration – the reaction between anhydrous cement and water vapour – has deleterious effects on engineering properties such as compressive strength, workability and setting time. This study assessed changes in the engineering properties of CEM I Portland cement exposed to relative humidities (RHs) of 60% or 85% for 7 and 28 days. Thin layers (no more than 2 mm thick) of CEM I 42.5R cement were exposed to controlled RHs of 60% and 85%, followed by assessment of compressive strength, setting time and workability. These measurements were complemented by characterising the prehydrated anhydrous cement using isothermal calorimetry, scanning electron microscopy, X-ray diffraction and thermal gravimetric analysis. Following prehydration at 60% RH, conventional hydration resulted in a negligible reduction in strength development plus a decrease in workability and increase in setting time. At 85% RH, compressive strength was greatly reduced, particularly at early ages. There was also a greater loss of workabili.
Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse

Wingless-related MMTV integration site 1 (WNT1)/β-catenin signaling plays a crucial role in the generation of mesodiencephalic dopaminergic (mdDA) neurons, including the substantia nigra pars compacta (SNc) subpopulation that preferentially degenerates in Parkinson's disease (PD). However, the precise functions of WNT1/β-catenin signaling in this context remain unknown. Stem cell-based regenerative (transplantation) therapies for PD have not been implemented widely in the clinical context, among other reasons because of the heterogeneity and incomplete differentiation of the transplanted cells. This might result in tumor formation and poor integration of the transplanted cells into the dopaminergic circuitry of the brain. Dickkopf 3 (DKK3) is a secreted glycoprotein implicated in the modulation of WNT/β-catenin signaling. Using mutant mice, primary ventral midbrain cells, and pluripotent stem cells, we show that DKK3 is necessary and sufficient for the correct differentiation of a rostrolateral mdDA neuron subset. Dkk3 transcription in the murine ventral midbrain coincides with the onset of mdDA neurogenesis and is required for the activation and/or maintenance of LMX1A (LIM homeobox transcription factor 1α) and PITX3 (paired-like homeodomain transcription factor 3) expression in the corresponding mdDA precursor subset, without affecting the proliferation or specification of their progenitors. Notably, the treatment of differentiating pluripotent stem cells with recombinant DKK3 and WNT1 proteins also increases the proportion of mdDA neurons with molecular SNc DA cell characteristics in these cultures. The specific effects of DKK3 on the differentiation of rostrolateral mdDA neurons in the murine ventral midbrain, together with its known prosurvival and anti-tumorigenic properties, make it a good candidate for the improvement of regenerative and neuroprotective strategies in the treatment of PD. SIGNIFICANCE STATEMENT We show here that Dickkopf 3 (DKK3), a secreted modulator of WNT (Wingless-related MMTV integration site)/β-catenin signaling, is both necessary and sufficient for the proper differentiation and survival of a rostrolateral (parabrachial pigmented nucleus and dorsomedial substantia nigra pars compacta) mesodiencephalic dopaminergic neuron subset, using Dkk3 mutant mice and murine primary ventral midbrain and pluripotent stem cells. The progressive loss of these dopamine-producing mesodiencephalic neurons is a hallmark of human Parkinson's disease, which can up to now not be halted by clinical treatments of this disease. Thus, the soluble DKK3 protein might be a promising new agent for the improvement of current protocols for the directed differentiation of pluripotent and multipotent stem cells into mesodiencephalic dopaminergic neurons and for the promotion of their survival in situ.
Monopolistic competition and new products: a conjectural equilibrium approach

In this paper we generalize the heterogeneous risk adverse agents model of diffusion of new products in a multi-firm, heterogeneous and interacting agents environment. We use a model of choice under uncertainty based on Bayesian theory. We discuss the possibility of product failures, the set of equilibria, their stability and some welfare properties depending on the degree of diversification.
A Role of Emotion in Problem Solving: Its Use as A Heuristic Mechanism

Performance and data from cognitive models suggest that changes in information processing should be included to reflect changes in motivation and confidence that accompany problem solving. Changes to the ACT–R cognitive architecture (Anderson & Lebiere, 1998) offer a possibility to model behaviour under different activational states or arousal, creating an activation theory of emotion. A model of the classical Yerkes–Dodson task exhibited the inverted–U effect of arousal on performance. The model also showed how dynamic changes in the decision process (of goal value and noise) based on problem solving success and failure can produce better results in matching the performance of subjects. We demonstrate that these dynamics of changes in motivation during problem solving correspond to well–known optimisation methods, such as best–first search and simulated annealing. This observation suggests that emotions may in fact help problem solving and improve intelligence.
Pure Hodge structure on the $L_2$-cohomology of varieties with isolated singularities

Let $V$ be a complex projective variety with isolated singularities. Let the smooth part be given the metric induced by a projective imbedding. Then we develop the $L_2$ harmonic theory and construct a pure Hodge structure on the $L_2$-cohomology of $V$. If the dimension of $V$ is two, we put a cohomological Hodge structure on its complex of sheaves of $L_2$ forms.
Antiovarian Antibody may be Used as A Predictor for Poor In Vitro Fertilization Outcome

Objective: The aim of this study is to demonstrate if there is any difference in the presence of antiovarian antibody (AOA) in normal fertile women and the ones having poor ovarian response and to examine if serum AOA levels could be used as a marker to detect patients at risk for poor ovarian reserve. Materials and Methods: 51 premature ovarian insufficiency (POI) patients, 47 poor responder (POR) patients to in vitro fertilization (IVF) and 51 healthy controls were included in the study. The patients were examined for their basal hormone values and antral follicle counts. Venous blood sampling for the detection of AOA was applied and ELISA technique was used to detect AOA concentrations. Results: The AOA levels were detected as 7.91 ± 1.11 U/mL in POI group, 5.72 ± 1.00 U/mL in the fertile group and 8.30 ± 0.75 U/mL in the POR group. It was significantly elevated in the POI and POR groups when compared to the fertile group (p< 0.001). There was not any difference between the AOA levels of POI and POR groups (p=0.053). The cut off levels of AOA for diagnosis of POI was detected to be 6.58 U/mL and for POR it was 7.78 U/mL. When these cut off levels were used, the sensitivity ratio was calculated as 90.2% for POI, and 94.74% for POR groups; whereas the specificity was 86.27% for POI and 83.05% for POR groups. In multivariate regression analysis of the POR group, AOA level was demonstrated to be the only significant independent variable in predicting the patients. Conclusion: Antiovarian autoimmunity plays a role in the etiopathogenesis of POI and POR; but the exact mechanism still needs to be elucidated with more clinical trials. AOA can be used as serum marker to detect the POR patients and predict IVF results. Immunosuppressive treatment of these patients may enhance the pregnancy outcomes.
Mycophenolate mofetil therapy in adult patients with recalcitrant atopic dermatitis

Abstract Background: Patients with severe atopic dermatitis (AD) may require potent immunosuppressive therapy to control their disease. Mycophenolate mofetil (MMF) has been suggested as a safe and effective drug in these cases. Objectives: To investigate effectiveness and tolerability of oral MMF in adult patients with severe recalcitrant AD. Methods: During the years 2010–2017 oral MMF 2–3 g/day was administered to adult patients with severe recalcitrant AD who failed other major systemic drugs, or where other drugs, including cyclosporine (CSA), methotrexate, and azathioprine, were contraindicated. Results: Of 9 consecutive adult patients, 4 (44%) responded completely, 2 (22%) had partial response, and 3 (33%) did not respond at all. The MMF therapy was continued for 5–36 months (average 21 months) without major side effects. Conclusions: Oral MMF may be an effective drug in AD. Due to its good safety profile, it may be recommended as a first-line systemic therapy, or successive to CSA in the long term.
Correlation between physical examination and three-dimensional gait analysis in the assessment of rotational abnormalities in children with cerebral palsy

Abstract Objective To evaluate the correlation between physical examination data concerning hip rotation and tibial torsion with transverse plane kinematics in children with cerebral palsy; and to determine which time points and events of the gait cycle present higher correlation with physical examination findings. Methods A total of 195 children with cerebral palsy seen at two gait laboratories from 2008 and 2016 were included in this study. Physical examination measurements included internal hip rotation, external hip rotation, mid-point hip rotation and the transmalleolar axis angle. Six kinematic parameters were selected for each segment to assess hip rotation and shank-based foot rotation. Correlations between physical examination and kinematic measures were analyzed by Spearman correlation coefficients, and a significance level of 5% was considered. Results Comparing physical examination measurements of hip rotation and hip kinematics, we found moderate to strong correlations for all variables (p<0.001). The highest coefficients were seen between the mid-point hip rotation on physical examination and hip rotation kinematics (rho range: 0.48-0.61). Moderate correlations were also found between the transmalleolar axis angle measurement on physical examination and foot rotation kinematics (rho range 0.44-0.56; p<0.001). Conclusion These findings may have clinical implications in the assessment and management of transverse plane gait deviations in children with cerebral palsy.
Single Cell Genomics: Advances and Future Perspectives

Advances in whole-genome and whole-transcriptome amplification have permitted the sequencing of the minute amounts of DNA and RNA present in a single cell, offering a window into the extent and nature of genomic and transcriptomic heterogeneity which occurs in both normal development and disease. Single-cell approaches stand poised to revolutionise our capacity to understand the scale of genomic, epigenomic, and transcriptomic diversity that occurs during the lifetime of an individual organism. Here, we review the major technological and biological breakthroughs achieved, describe the remaining challenges to overcome, and provide a glimpse into the promise of recent and future developments.
Investigating Managers' Exploration and Exploitation Activities: The Influence of Top-Down, Bottom-Up, and Horizontal Knowledge Inflows

This paper develops and tests hypotheses on the influence of a manager’s knowledge inflows on this manager’s exploration and exploitation activities. Based on a survey among managers of a leading electronics firm, the findings indicate, as expected, that top-down knowledge inflows of a manager positively relate to the extent to which this manager conducts exploitation activities, while they do not relate to a manager’s exploration activities. Furthermore, as expected, bottom-up and horizontal knowledge inflows of a manager positively relate to this manager’s exploration activities, while they do not relate to a manager’s exploitation activities. We contribute to current literature on exploration and exploitation by focusing on the manager level of analysis, and by adding the importance of knowledge flow configurations to the literature on the impact of organizational factors upon exploration and exploitation.
Evaluation of a semi-nested PCR for detection of Renibacterium salmoninarum in samples from kidney, gill and ovarian fluid of Atlantic salmon broodfish

A semi-nested PCR (snPCR) for detection of Renibacterium salmoninarum that causes bacterial kidney disease (BKD) in salmonids was constructed. The efficacy of the snPCR was evaluated by comparison with nested PCR (nPCR) and two ELISA methods on kidney, ovarian fluid and gill samples collected from Atlantic salmon broodfish with escalating disease. The PCR methods using a conventional isolation kit identified equal numbers of positive samples, or 30%, with acceptable agreement. The ratio of positive kidney samples in PCR increased significantly, 42.5% in snPCR and 45% in nPCR, when an FTA minicard was used for DNA isolation. ELISA, using polyclonal antibodies, detected the highest number of positive samples (65%) and ELISA using monoclonal antibodies the lowest (17.5%). Ovarian fluid and gills gave inadequate results and cannot replace kidney samples for determination of R. salmoninarum infection in Atlantic salmon broodfish.
Increasing water‐use efficiency and age‐specific growth responses of old‐growth ponderosa pine trees in the Northern Rockies

We examined radial growth responses of ponderosa pine (Pinus ponderosa var. ponderosa) between 1905–1954 and 1955–2004 to determine if the effects of increased intrinsic water‐use efficiencies (iWUE) caused by elevated atmospheric CO2 concentrations were age‐specific. We collected 209 cores from five sites in the Northern Rockies and calculated iWUE using carbon isotope data from 1850 to 2004. Standardized radial growth responses were age dependent, with older trees exhibiting significantly higher values than younger trees during the later period at four sites and all sites combined. No significant differences in radial growth existed either for the individual sites or combined site during the earlier period. Increases in iWUE during 1955–2004 were 11% greater than during 1905–1954, and pentadal fluctuations in iWUE were significantly correlated with the radial growth of older trees from 1850 to 2004. Radial growth of younger trees and iWUE were not significantly correlated. Our results suggest that: (1) responses to elevated atmospheric CO2 in old‐growth ponderosa forests are age‐specific; (2) radial growth increases in older trees coincided with increased iWUE; (3) ponderosa had increased growth rates in their third, fourth, and fifth centuries of life; and (4) age‐specific growth responses during 1955–2004 are unique since at least the mid‐16th century.
Stalking: false claims of victimisation

Background False allegations of victimisation although uncommon are important to recognise. This paper examines those who falsely claim to have been the victims of stalking. Aims To highlight the phenomenon of false victims of stalking. Method Twelve individuals who falsely claimed to be victims of stalking were compared with a group of 100 true stalking victims. Results False stalking victims presented for help earlier than real victims and were less likely to claim harassment via letters. They reported equivalent levels of violence directed at themselves but seldom claimed others were attacked. Five types of false claimants were recognisable. False victims consumed more medical services than genuine stalking victims and they were more likely to be embroiled in legal action. They reported similar levels of distress with suicidal ruminations in over 40%. Conclusions The current interest in stalking is promoting false claims of being stalked. Early identification of these cases and appropriate intervention are essential to both minimising abuses of resources available to true victims and equally to ensure appropriate care for those who express their own disordered state in false claims of victimisation.
Experimental Comparison of Three Floating Wind Turbine Concepts

Beyond many of the Earth’s coasts exist a vast deepwater wind resource that can be tapped to provide substantial amounts of clean, renewable energy. However, much of this resource resides in waters deeper than 60 m where current fixed bottom wind turbine technology is no longer economically viable. As a result, many are looking to floating wind turbines as a means of harnessing this deepwater offshore wind resource. The preferred floating platform technology for this application, however, is currently up for debate. To begin the process of assessing the relative advantages of various platform concepts for floating wind turbines, 1/50 th scale model tests in a wind/wave basin were performed at MARIN (Maritime Research Institute Netherlands) of three floating wind turbine concepts. The Froude scaled tests simulated the behavior of the 126 m rotor diameter NREL (National Renewable Energy Lab) 5 MW, horizontal axis Reference Wind Turbine attached via a flexible tower in turn to three distinct platforms, these being a tension leg-platform, a spar-buoy and a semi-submersible. A large number of tests were performed ranging from simple free-decay tests to complex operating conditions with irregular sea states and dynamic winds. The high-quality wind environments, unique to these tests, were realized in the offshore basin via a novel wind machine which exhibited low swirl and turbulence intensity in the flow field. Recorded data from the floating wind turbine models include rotor torque and position, tower top and base forces and moments, mooring line tensions, six-axis platform motions and accelerations at key locations on the nacelle, tower, and platform. A comprehensive overview of the test program, including basic system identification results, is covered in an associated paper in this conference. In this paper, the results of a comprehensive data analysis are presented which illuminate the unique coupled system behavior of the three floating wind turbines subjected to combined wind and wave environments. The relative performance of each of the three systems is discussed with an emphasis placed on global motions, flexible tower dynamics and mooring system response. The results demonstrate the unique advantages and disadvantages of each floating wind turbine platform.