Miracle-dz/UniFAR-FTUs huggingface dataset:
The workload of riding-school horses during jumping.

REASONS FOR PERFORMING THE STUDY As there are no reports on the real workload of horses that jump fences, this study was undertaken in riding-school horses. OBJECTIVE To compare the workload of horses jumping a course of fences with that of horses cantering over the same course at the same average speed without jumping fences. The workload variables included heart rate (HR), packed cell volume (PCV), acid-base balance (venous pH, pCO2, HCO3-) and blood lactate (LA), glucose, total protein and electrolyte concentrations. METHODS Eight healthy riding-school horses performed test A (a course of approximately 700 m with 12 jumps from 0.8-1.0 m high at an average speed of approximately 350 m/min) and test B (same course at the same speed, but without the rails) in a crossover study with at least 4 h between the 2 tests. Before each test the horses were fitted with a heart rate meter (Polar Electro). Blood samples were taken from the jugular vein at rest prior to the test, after warm-up before starting the course, immediately after the course and after recovery. All samples were analysed immediately. RESULTS The mean +/- s.d maximal HR (beats/min) during the course (184 +/- 17 and 156 +/- 21, respectively) and the mean HR after recovery (75 +/- 6 and 63 +/- 7, respectively) were significantly higher in test A compared to test B (P = 0.001 and P = 0.007 respectively). The mean LA concentrations after the course and after recovery (mmol/l) were significantly higher in test A (3.6 +/- 2.7 and 1.0 +/- 0.9, respectively) compared to test B (0.9 +/- 0.5 and 0.3 +/- 0.1, respectively), (P = 0.016 and P = 0.048 respectively). The mean PCV (I/l) after the course and after recovery was also significantly different between tests A (0.48 +/- 0.04 and 0.39 +/- 0.03, respectively) and B (0.42 +/- 0.04 and 0.36 +/- 0.03, respectively) (P<0.01). The mean pH and the mean HCO3- (mmol/l) after the course were significantly lower in test A (7.40 +/- 0.04 and 28.9 +/- 1.4, respectively) compared to test B (7.45 +/- 0.03 and 30.4 +/- 2.3, respectively) (P<0.05). CONCLUSIONS This study indicates that in riding-school horses jumping fences, even at a low level competition, provokes a significant workload compared to cantering the same distance and speed without fences. POTENTIAL RELEVANCE This study makes it clear that the extra workload of jumping fences should be taken into account in the training programmes of jumping horses. Further research with more experienced horses jumping higher fences will reveal the workload for top-level jumping horses.
Customers' Influence Makes or Breaks Your Brand's Success Story - Accounting for Positive and Negative Social Influence in Online Customer Networks

The ongoing proliferation of digital technologies is reshaping the customer-firm relationship by providing new possibilities for companies and customers to interact with each other. Companies try to involve customers in firm-sponsored online customer networks to connect them more deeply with the brand. In this context, the impact of positive social influence induced among customers on their value contribution has been acknowledged, however, research often neglects the impact of negative social influence. We propose therefore a novel approach to account for direct and indirect as well as positive and negative social influence between customers in online customer networks to calculate customers’ integrated value contribution. We demonstrate the applicability of our approach using an illustrative online customer network. Our approach allows practitioners to evaluate customers’ “true” value in online customer networks by preventing over- and underestimation of customers’ value contribution.
Reactivation of M. tuberculosis Infection in Trans-Membrane Tumour Necrosis Factor Mice

Of those individuals who are infected with M. tuberculosis, 90% do not develop active disease and represents a large reservoir of M. tuberculosis with the potential for reactivation of infection. Sustained TNF expression is required for containment of persistent infection and TNF neutralization leads to tuberculosis reactivation. In this study, we investigated the contribution of soluble TNF (solTNF) and transmembrane TNF (Tm-TNF) in immune responses generated against reactivating tuberculosis. In a chemotherapy induced tuberculosis reactivation model, mice were challenged by aerosol inhalation infection with low dose M. tuberculosis for three weeks to establish infection followed chemotherapeutic treatment for six weeks, after which therapy was terminated and tuberculosis reactivation investigated. We demonstrate that complete absence of TNF results in host susceptibility to M. tuberculosis reactivation in the presence of established mycobacteria-specific adaptive immunity with mice displaying unrestricted bacilli growth and diffused granuloma structures compared to WT control mice. Interestingly, bacterial re-emergence is contained in Tm-TNF mice during the initial phases of tuberculosis reactivation, indicating that Tm-TNF sustains immune pressure as in WT mice. However, Tm-TNF mice show susceptibility to long term M. tuberculosis reactivation associated with uncontrolled influx of leukocytes in the lungs and reduced IL-12p70, IFNγ and IL-10, enlarged granuloma structures, and failure to contain mycobacterial replication relative to WT mice. In conclusion, we demonstrate that both solTNF and Tm-TNF are required for maintaining immune pressure to contain reactivating M. tuberculosis bacilli even after mycobacteria-specific immunity has been established.
The seroepidemiology of rubella in western Europe

Most of the countries in western Europe have now implemented mass infant rubella immunization programmes, instead of or in addition to selective vaccination in order to achieve the elimination of congenital rubella syndrome. The European countries Denmark, England and Wales, Finland, France, Germany, Italy and the Netherlands undertook large, national serological surveys collecting several thousand serum specimens during 1994–8. Antibodies against rubella virus were detected by a variety of enzyme immuno-assays. Comparability of the assay results was achieved by a standardized methodology. The age- and sex-stratified serological results were related to the schedules, coverage of rubella vaccination and the incidence in these countries. The results show widely differing levels of immunity to rubella both in the general population and in the specific age groups of males and females. A low rate (< 5%) of susceptibles in childhood and adolescents of both sexes was obtained only in Finland and the Netherlands. Countries such as Italy with only moderate coverage for the infant immunization programme currently have both high susceptibility levels in the general population and in the at-risk population. The likelihood is of continued epidemics of rubella with cases of congenital rubella syndrome. The continued implementation of selective vaccination will help to offset the impact of this ongoing transmission and to protect women on reaching childbearing age.
Adaptive strategy for stratified Monte Carlo sampling

We consider the problem of stratified sampling for Monte Carlo integration of a random variable. We model this problem in a K-armed bandit, where the arms represent the K strata. The goal is to estimate the integral mean, that is a weighted average of the mean values of the arms. The learner is allowed to sample the variable n times, but it can decide on-line which stratum to sample next. We propose an UCB-type strategy that samples the arms according to an upper bound on their estimated standard deviations. We compare its performance to an ideal sample allocation that knows the standard deviations of the arms. For sub-Gaussian arm distributions, we provide bounds on the total regret: a distribution-dependent bound of order poly(λmin-1)O(n-3/2)1 that depends on a measure of the disparity λmin of the per stratum variances and a distribution-free bound poly(K)O(n-7/6) that does not. We give similar, but somewhat sharper bounds on a proxy of the regret. The problem-independent bound for this proxy matches its recent minimax lower bound in terms of n up to a log n factor.
How did the failure come to be?

Upon a program failure, programmers ask how the failure came to be. Modern debugging tools employ sophisticated mechanisms to help answering this question. These mechanisms embody a spectrum of contributions to program comprehension. In this paper, we study this spectrum with the goal of finding an optimal position. We define the optimal position as the set of techniques which tools can employ to efficiently answer this debugging question. Our position demands a big picture of a program execution, which is essential for better program comprehension. We demonstrate our position with two case studies. We envision that emerging debugging tools can benefit from taking this position to facilitate the debugging process.
The ACCORD (Action to Control Cardiovascular Risk in Diabetes) Lipid Trial

Atherosclerotic cardiovascular disease is increased severalfold in most patients with type 2 diabetes, particularly patients who are older and have other risk factors (1,2). These associated risk factors include hypertension, obesity, and dyslipidemia. Diabetic dyslipidemia, which has also been called atherogenic dyslipidemia (a term that describes the lipid abnormalities in people with insulin resistance, metabolic syndrome, and type 2 diabetes), is characterized by elevated plasma triglyceride (TG) levels, low levels of HDL cholesterol, and smaller cholesterol ester–depleted LDL (3). Despite the fact that statins, which mainly lower blood levels of LDL cholesterol, have the same relative effectiveness in type 2 diabetic patients as in nondiabetic subjects, absolute rates of atherosclerotic cardiovascular disease events remained higher in patients with diabetes who participated in all of the statin trials (4,5). These findings have raised interest in the use of combination therapy, particularly the combination of a statin plus a drug that would lower plasma TG levels and raise plasma HDL cholesterol levels. ACCORD (Action to Control Cardiovascular Risk in Diabetes) was specifically designed to determine the effects of intensive treatment of blood glucose, and either blood pressure (ACCORD Blood Pressure) or plasma lipids (ACCORD Lipid), on atherosclerotic cardiovascular disease outcomes in patients with type 2 diabetes who were at high risk of such an outcome (6). The ACCORD Lipid trial tested the hypothesis that treatment of patients with type 2 diabetes with fenofibrate to increase plasma HDL cholesterol levels and reduce plasma TG concentrations, on the …
In Vivo Efficacy of Anti-Glycoprotein 41, But Not Anti-Glycoprotein 120, Immunotoxins in a Mouse Model of HIV Infection 1

Immunotoxins (ITs) targeting the HIV envelope protein are among the most efficacious antiviral therapies when tested in vitro. Yet a first-generation IT targeted to gp120, CD4-PE40 (chimeric immunotoxin using CD4 and the translocation and enzymatic domains of Pseudomonas exotoxin A), showed limited promise in initial clinical testing, highlighting the need for improved ITs. We have used a new mouse model of HIV infection to test the comparative efficacy of anti-HIV ITs targeted to gp120 or to gp41. Irradiated SCID/nonobese diabetic mice are injected with a tumor of human CD4+ cells susceptible to infection and at a separate site persistently HIV-infected cells. The spread of infection from infected to susceptible tumor is monitored by plasma p24 and the presence of HIV-infected cells in the spleen. Anti-gp41 ITs in combination with tetrameric CD4-human Ig fusion protein have pronounced anti-HIV effects. Little if any anti-HIV efficacy was found with either CD4-PE40 or an Ab-targeted anti-gp120 IT. These data support continued exploration of the utility of ITs for HIV infection, particularly the use of anti-gp41 ITs in combination with soluble CD4 derivatives.
Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

Much of the public media discussion of genetics of common diseases has centered on opportunities for targeted preventive actions. At the same time, in the specialist literature, there has been extensive discussion of “interaction,” both between genes and between genes and environment. These two topics concern the use and interpretation of statistical models for risk of diseases with several, perhaps many, etiological risk factors, and were both the subject of lively debate some 30 to 40 years ago when such models first came into widespread use in epidemiology. Here these debates are revisited and illustrated with results from an analysis of the genetics of type 1 diabetes (T1D). Details of this analysis are provided in section 1 of Text S1.
In Vitro Activities of Eight Antifungal Drugs against 55 Clinical Isolates of Fonsecaea spp

ABSTRACT The in vitro activities of eight antifungal drugs against clinical isolates of Fonsecaea pedrosoi (n = 21), Fonsecaea monophora (n = 25), and Fonsecaea nubica (n = 9) were tested. The resulting MIC90s for all strains (n = 55) were as follows, in increasing order: posaconazole, 0.063 μg/ml; itraconazole, 0.125 μg/ml; isavuconazole, 0.25 μg/ml; voriconazole, 0.5 μg/ml; amphotericin B, 2 μg/ml; caspofungin, 2 μg/ml; anidulafungin, 2 μg/ml; and fluconazole, 32 μg/ml.
Quantitative ethnobotany of Lophira lanceolata Tiegh. ex Keay (Ochnaceae) in Benin (West Africa)

Understanding the utilization of plant is fundamental for efficient conservation of species. The present study aimed at assessing the quatitative ethnobotany of Lophira lanceolata Tiegh. ex Keay (Ochnaceae) utilization in Benin. A number of 1261 persons were randomly selected and interviewed using semi-structured questionnaires. Principal Components Analysis was performed to relate utilizations and organs to ethnic groups. The diversity (ID) and equitability (IE) values were globally low (< 0.50) and indicated that local knowledge on L. lanceolata utilization is not fairly distributed among groups. L. lanceolata was not wellknown by all the respondents and its utilization varied significantly among ethnic groups, between sex and fairly between age classes. The ethnic group consensus values for L. lanceolata parts showed that leaves are the most used organ. Local knowledge on the species was well-diversified and was influenced by the ethnic group. Our study has provided basic information that may help for sustainable management and conservation of the species in Benin. Keywords : False shea, endogenous knowledge, ethnic differences, use value, use pattern.
Drinking to Get Drunk Among Incoming Freshmen College Students

Abstract Background: The consumption of alcohol is ubiquitous on many college and university campuses. For some freshmen students, drinking may even be considered a “right of passage. ” Purpose: This study examined college freshmen who intentionally drink alcohol to get drunk (DTGD). Methods: Survey data from 307 incoming freshmen college students living in freshmen residence halls who reported drinking alcohol in the last 30 days were analyzed. Results: The majority (76.9%) of these self-reported drinkers reported DTGD. Relative to other freshmen drinkers, those who reported DTGD were significantly more likely to have consumed alcohol before going out to a party or bar, participated in a drinking game, drank heavily on a non-school night but not on a school night, used liquor, used beer, combined alcohol and drugs, experienced a hangover, vomited, passed out, and/or blacked out. Discussion: The associations support DTGD as a measure of pre-meditated, controlled and intentional consumption of alcohol to reach a state of inebriation. Translation to Health Education Practice: Common intentional drunkenness as observed in this study population may have implications for college alcohol risk reduction programs.
High-throughput sequencing reveals a simple model of nucleosome energetics

We use genome-wide nucleosome maps to study sequence specificity of intrinsic histone-DNA interactions. In contrast with previous approaches, we employ an analogy between a classical one-dimensional fluid of finite-size particles in an arbitrary external potential and arrays of DNA-bound histone octamers. We derive an analytical solution to infer free energies of nucleosome formation directly from nucleosome occupancies measured in high-throughput experiments. The sequence-specific part of free energies is then captured by fitting them to a sum of energies assigned to individual nucleotide motifs. We have developed hierarchical models of increasing complexity and spatial resolution, establishing that nucleosome occupancies can be explained by systematic differences in mono- and dinucleotide content between nucleosomal and linker DNA sequences, with periodic dinucleotide distributions and longer sequence motifs playing a minor role. Furthermore, similar sequence signatures are exhibited by control experiments in which nucleosome-free genomic DNA is either sonicated or digested with micrococcal nuclease, making it possible that current predictions based on high-throughput nucleosome-positioning maps are biased by experimental artifacts.
Systems Biomedicine of Rabies Delineates the Affected Signaling Pathways

The prototypical neurotropic virus, rabies, is a member of the Rhabdoviridae family that causes lethal encephalomyelitis. Although there have been a plethora of studies investigating the etiological mechanism of the rabies virus and many precautionary methods have been implemented to avert the disease outbreak over the last century, the disease has surprisingly no definite remedy at its late stages. The psychological symptoms and the underlying etiology, as well as the rare survival rate from rabies encephalitis, has still remained a mystery. We, therefore, undertook a systems biomedicine approach to identify the network of gene products implicated in rabies. This was done by meta-analyzing whole-transcriptome microarray datasets of the CNS infected by strain CVS-11, and integrating them with interactome data using computational and statistical methods. We first determined the differentially expressed genes (DEGs) in each study and horizontally integrated the results at the mRNA and microRNA levels separately. A total of 61 seed genes involved in signal propagation system were obtained by means of unifying mRNA and microRNA detected integrated DEGs. We then reconstructed a refined protein-protein interaction network (PPIN) of infected cells to elucidate biological signaling transduction pathways affected by rabies virus. To validate our findings, we confirmed differential expression of randomly selected genes in the network using Real-time PCR. In conclusion, the identification of seed genes and their network neighborhood within the refined PPIN can be useful for demonstrating signaling pathways including interferon circumvent, toward proliferation and survival, and neuropathological clue, explaining the intricate underlying molecular neuropathology of rabies infection and thus rendered a molecular framework for predicting potential drug targets.
Increasing the Cell Number of Host Tetraploid Embryos Can Improve the Production of Mice Derived from Embryonic Stem Cells1

Abstract Tetraploid (4n) embryo complementation assay has shown that embryonic stem (ES) cells alone are capable of supporting embryonic development (ES mouse), allowing the recovery of mouse lines directly from cultured ES cell lines. Although the advantages of this technique are well recognized, it remains inefficient for generating ES mice. In the present study, we investigated the effects of cell number of host 4n embryos on the production of ES mice. Four independent ES cell lines (two general ES cell lines and two nuclear transfer-derived ES cell lines) were used, and each cell line was aggregated with single (1×) to triple (3×) host 4n embryos. We found that birth rate of ES mice using 1× 4n embryos was quite low (0–2%) regardless of cell line, whereas except for one cell line, approximately 6–14% of embryos developed to full term in the case of 3× 4n embryos. Contamination of host 4n cells in ES mice was quite rare, being comparable to that generated using general methods even if they were delivered from 3× 4n host embryos. These results demonstrate that the use of 3× 4n embryos is effective for generating ES mice. Our technique described here will be applicable to any ES cell line, including general ES cell lines used for gene targeting.
Empirical Evaluation of Cross-Release Effort-Aware Defect Prediction Models

To prioritize quality assurance efforts, various fault prediction models have been proposed. However, the best performing fault prediction model is unknown due to three major drawbacks: (1) comparison of few fault prediction models considering small number of data sets, (2) use of evaluation measures that ignore testing efforts and (3) use of n-fold cross-validation instead of the more practical cross-release validation. To address these concerns, we conducted cross-release evaluation of 11 fault density prediction models using data sets collected from 2 releases of 25 open source software projects with an effort-aware performance measure known as Norm(Popt). Our result shows that, whilst M5 and K* had the best performances, they were greatly influenced by the percentage of faulty modules present and size of data set. Using Norm(Popt) produced an overall average performance of more than 50% across all the selected models clearly indicating the importance of considering testing efforts in building fault-prone prediction models.
Size and Structure of the Narrow-Line Region of Quasars

We have observed the narrow-line regions (NLRs) of the seven brightest radio-quiet Palomar-Green (or Bright Quasar Survey) quasars (z < 0.5) with the Wide Field Planetary Camera 2 on board the Hubble Space Telescope (HST). Linear-ramp filters were used to image the [O III] λ5007 line emission with 0. ″0455-0. ″1 pixel resolution. We find that the NLRs are very compact with typical extents of 2''-4''. Two quasars show compact filamentary structures similar to Seyfert NLRs. They may be related to radio outflows. Most interestingly, when including a sample of Seyfert galaxies observed with HST, we tentatively find that the size of the NLR is proportional to the square root of the [O III] luminosity. This is comparable to the scaling found for the size of the broad-line region with continuum luminosity, which has been interpreted in terms of a constant photoionization parameter. The relation determined here connects the NLR of radio-quiet quasars and Seyfert galaxies over 3 orders of magnitude in [O III] luminosity.