Miracle-dz/UniFAR-FTUs huggingface dataset:
Financial Integration, Entrepreneurial Risk and Global Dynamics

How does financial integration impact capital accumulation, current-account dynamics, and cross-country inequality? We investigate this question within a two-country, general-equilibrium, incomplete-markets model that focuses on the importance of idiosyncratic entrepreneurial risk--a risk that introduces, not only a precautionary motive for saving, but also a wedge between the interest rate and the marginal product of capital. Our contribution is to show that this friction provides a simple explanation for the emergence of global imbalances, a resolution to the empirical puzzle that capital often fails to flow from the rich or slow-growing countries to the poor or fast-growing ones, and a set of policy lessons regarding the intertemporal costs and benefits of capital-account liberalization.
The noncommutative geometry of the $Y^{p,q}$ quivers

Let A be a Y p,q quiver algebra with center Z. We classify the irreducible representations of A, show that A is homologically homogeneous of global dimension 3, and show that the smooth locus of Z and the Azumaya locus of A coincide. In addition, we find that the primitive ideals of A which reduce to the singular points of Z may be viewed as exceptional divisors shrunk to zero size by comparing constraints determined by the symplectic quotient construction with constraints determined by requiring the representations be irreducible. In terms of physics, the global gauge transformations of the Y p,q quiver gauge theories are determined. The bulk fractional D3-branes are found to coincide with and resolve the singularities of the vacuum moduli space, following Berenstein's method of reverse-geometric engineering in string theory.
Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene Transfer

ABSTRACT In the genetic disease cystic fibrosis, recombinant adeno-associated virus type 2 (AAV2) is being investigated as a vector to transfer CFTR cDNA to airway epithelia. However, earlier work has shown that the apical surface of human airway epithelia is resistant to infection by AAV2, presumably as a result of a lack of heparan sulfate proteoglycans on the apical surface. This inefficiency can be overcome by increasing the amount of vector or by increasing the incubation time. However, these interventions are not very practical for translation into a therapeutic airway-directed vector. Therefore, we examined the efficiency of other AAV serotypes at infecting human airway epithelia. When applied at low multiplicity of infection to the apical surface of differentiated airway epithelia we found that a recombinant AAV5 bound and mediated gene transfer 50-fold more efficiently than AAV2. Furthermore, in contrast to AAV2, AAV5-mediated gene transfer was not inhibited by soluble heparin. Recombinant AAV5 was also more efficient than AAV2 in transferring β-galactosidase cDNA to murine airway and alveolar epithelia in vivo. These data suggest that AAV5-derived vectors bind and mediate gene transfer to human and murine airway epithelia, and the tropism of AAV5 may be useful to target cells that are not permissive for AAV2.
A randomized trial of anticoagulants versus aspirin after cerebral ischemia of presumed arterial origin

Aspirin is only modestly effective in the secondary prevention after cerebral ischemia. Studies in other vascular disorders suggest that anticoagulant drugs in patients with cerebral ischemia of presumed arterial (noncardiac) origin might be more effective. The aim of the Stroke Prevention in Reversible Ischemia Trial (SPIRIT) therefore was to compare the efficacy and safety of 30 mg aspirin daily and oral anticoagulation (international normalized ratio [INR] 3.0–4.5). Patients referred to a neurologist in one of 58 collaborating centers because of a transient ischemic attack or minor ischemic stroke (Rankin grade $3) were eligible. Randomization was concealed, treatment assignment was open, and assessment of outcome events was masked. The primary measure of outcome was the composite event “death from all vascular causes, nonfatal stroke, nonfatal myocardial infarction, or nonfatal major bleeding complication. ” The trial was stopped at the first interim analysis. A total of 1,316 patients participated; their mean follow‐up was 14 months. There was an excess of the primary outcome event in the anticoagulated group (81 of 651) versus 36 of 665 in the aspirin group (hazard ratio, 2.3; 95% confidence interval [CI], 1.6–3.5). This excess could be attributed to 53 major bleeding complications (27 intracranial; 17 fatal) during anticoagulant therapy versus 6 on aspirin (3 intracranial; 1 fatal). The bleeding incidence increased by a factor of 1.43 (95% CI, 0.96–2.13) for each 0.5 unit increase of the achieved INR. Anticoagulant therapy with an INR range of 3.0 to 4.5 in patients after cerebral ischemia of presumed arterial origin is not safe. The efficacy of a lower intensity anticoagulation regimen remains to be determined.
User Satisfaction with Virtual Social Community: The Case of Bulletin Board Systems

Building upon expectation confirmation theory and elaboration likelihood model, this study proposed and empirically tested a research model of user satisfaction with virtual social community. An online questionnaire was posted in the Bulletin Board Systems of a local university in Mainland China. A total of 240 online questionnaires were collected, and the data was analyzed using partial least squares. The research model provided over 70 percent of variance explained in user satisfaction with virtual social community. Relevance and comprehensiveness of messages, and disconfirmations of relevance and accuracy of messages are found statistically significant. The dimensions of perceived source credibility (including source expertise and source trustworthiness) are not found significant, but their disconfirmations are found statistically significant. Implications of this study are noteworthy for both researchers and practitioners.
A comparative assessment of clinical whole exome and transcriptome profiling across sequencing centers: implications for precision cancer medicine

Advances in next generation sequencing technologies provide approaches to comprehensively determine genomic alterations within a tumor that occur as a cause or consequence of neoplastic growth. Though providers offering various cancer genomics assays have multiplied, the level of reproducibility in terms of the technical sensitivity and the conclusions resulting from the data analyses have not been assessed. We sought to determine the reproducibility of ascertaining tumor genome aberrations using whole exome sequencing (WES) and RNAseq. Samples of the same metastatic tumors were independently processed and subjected to WES of tumor and constitutional DNA, and RNAseq of RNA, at two sequencing centers. Overall, the sequencing results were highly comparable. Concordant mutation calls ranged from 88% to 93% of all variants including 100% agreement across 154 cancer-associated genes. Regions of copy losses and gains were uniformly identified and called by each sequencing center and chromosomal plots showed nearly identical patterns. Transcript abundance levels also exhibited a high degree of concordance (r2 ≥ 0.78;Pearson). Biologically-relevant gene fusion events were concordantly called. Exome sequencing of germline DNA samples provided a minimum of 30X coverage depth across 56 genes where incidental findings are recommended to be reported. One possible pathogenic variant in the APC gene was identified by both sequencing centers. The findings from this study demonstrate that results of somatic and germline sequencing are highly concordant across sequencing centers that have substantial experience in the technological requirements for preparing, sequencing and annotating DNA and RNA from human biospecimens.
Matching Algorithm of Web Services Based on Semantic Distance

With the growing number of web services ,the importance of matching and discovery web services is increasing. Using domain ontology to describe the semantic of web services and matching the web services on the semantic level is a hot research pot. In this paper, the problem of matching web services is transformed to the computation of semantic similarity between concepts in domain ontology. We propose the semantic similarity can be measured from the semantic distance and consider the factors of pathlengh, depth, local density and numberofdowndir- ection in the algorithm. We establish that such a measure is an effective means of discriminating services at a level of granularity that is able to enhance the matching process in semantic web services. Index Terms—domain ontology, matchmaking the Web Services,semantic similarity,semantic distance
Identification of a Small-Molecule Inhibitor of Bacterial AraC Family Activators

Protein members of the AraC family of bacterial transcriptional activators have great promise as targets for the development of novel antibacterial agents. Here, we describe an in vivo high-throughput screen to identify inhibitors of the AraC family activator protein RhaS. The screen used two Escherichia coli reporter fusions: one to identify potential RhaS inhibitors and a second to eliminate nonspecific inhibitors from consideration. One compound with excellent selectivity, OSSL_051168, was chosen for further study. OSSL_051168 inhibited in vivo transcription activation by the RhaS DNA-binding domain to the same extent as the full-length protein, indicating that this domain was the target of its inhibition. Growth curves showed that OSSL_051168 did not affect bacterial cell growth at the concentrations used in this study. In vitro DNA-binding assays with purified protein suggest that OSSL_051168 inhibits DNA binding by RhaS. In addition, we found that it inhibits DNA binding by a second AraC family protein, RhaR, which shares 30% amino acid identity with RhaS. OSSL_051168 did not have a significant impact on DNA binding by the non-AraC family proteins CRP and LacI, suggesting that the inhibition is likely specific for RhaS, RhaR, and possibly additional AraC family activator proteins.
Creating , Integrating and Maintaining Local and Global Ontologies

1Mathematics and Computing Technology, Phantom Works, The Boeing Company. Seattle, WA USA; Email: michael.f. uschold@boeing.com Abstract. In this paper, we explore the issues related to creating, integrating and maintaining multiple local ontologies, and how and whether a global reference ontology can be of use. We note that a major problem in existing organizations is the lack of consistent terminology. The adoption of a global reference vocabulary or ontology seems an attractive solution in theory, but in practice, this approach seems untenable. We believe that a mixed approach which enables local groups to build maintain and use their own ontologies, in conjunction with a global reference ontology, and mapping between them is a more viable approach. We describe various issues and approaches that arise in attempting to do this.
Role of fibrillatory waves amplitude as predictors of immediate arrhythmia termination after Maze surgery of atrial fibrillation

Cox-Maze surgery is an effective procedure to terminate atrial fibrillation (AF) in patients requiring open-heart surgery associated to another heart disease. After the intervention, AF spontaneous reversion occurs immediately in some patients, but not in others. This work analyzes 23 twelve-lead preoperative ECGs from patients in AF to predict immediate termination of the arrythmia. To carry out the prediction, three indices have been studied: the dominant atrial frequency (DAF), the sample entropy (SampEn) and the fibrillatory waves average power (fWP). Results for the DAF yielded a Sensitivity (Se), Specificity (Sp) and Accuracy (Acc) of 78%, 71% and 74%, respectively. For SampEn 78%, 79% and 78%, respectively and for fWP were 89%, 71% and 78%, respectively. Finally, to improve the prognosis capability a classification tree combining the analyzed parameters was created yielding Se, Sp and Acc of 89%, 93% and 91%, respectively. As conclusion, the combination of fWP with DAF and SampEn has provided very auspicious results to predict whether AF would terminate immediately after the Cox-Maze surgery.
Accidents in Norwegian secondary school friluftsliv: implications for teacher and student competence

ABSTRACT This article reports and discusses results from a nationwide, quantitative survey of accidents and near-accidents in educational outdoor activities (friluftsliv) in Norwegian upper secondary schools during the period 2010–2013. The data were analysed using descriptive statistics and association analyses. The results reveal that accidents and near-accidents occur regularly, but no fatalities occurred in the three-year period studied. We found few statistically significant associations between variables, yet among the variations of teacher education in friluftsliv one year of teacher education reduced the likelihood of reporting accidents (odds ratio = 0.35, p = 0.007) and lack of any friluftsliv teacher education increased the likelihood of reporting accidents (odds ratio = 2.23, p = 0.048). The results regarding accident and near-accident causes are not very clear, although teachers tend to consider chance factors and student preparedness to be more important causes than other factors. Internationally, and particularly in Norway, there is a need for better knowledge for minimizing accidents and near-accidents in outdoor educational activities for youth.
Liquidity, government bonds and sovereign debt crises

This paper analyses the European financial crisis through the lens of sovereign bond liquidity. Using novel data we show that government securities are the prime collateral in the European repo market, which is becoming an essential source of funding for the banking system in the Euro area. We document that repo haircuts on peripheral government bonds sharply increased during the crisis, reducing their liquidity and amplifying the raise in the yields of these securities. We study the systemic impact of a liquidity shock on the business cycle and asset prices through a dynamic stochastic general equilibrium model with liquidity frictions. The model predicts a drop in economic activity, inflation and value of illiquid government bonds. We show that an unconventional policy which consists of purchasing illiquid bonds by issuing liquid bonds can alleviate the contractionary effect of liquidity shock. A Bayesian structural vector autoregressive model for the Irish economy confirms empirically the negative impact of a rise in haircuts on the value of government bonds.
Looking at the label: White-collar men and the meanings of “metrosexual”

How do men feel about the “metrosexual” label? How do their views relate to changing norms of masculine self-presentation and increasing acceptance of “out” gay men? We interviewed 30 US white-collar men, who generally expressed ambivalence about the social category of metrosexual and claimed that the practices associated with it were now the norm, while differentiating between the labels of gay and metrosexual. We argue that metrosexuality raises new possibilities for gay-straight alliances and more varied performances of heterosexual masculinity, at work and beyond. However, these developments seem to reinscribe rather than reconfigure power relations privileging heterosexual men.
LH*—a scalable, distributed data structure

We present a scalable distributed data structure called LH*. LH* generalizes Linear Hashing (LH) to distributed RAM and disk files. An LH* file can be created from records with primary keys, or objects with OIDs, provided by any number of distributed and autonomous clients. It does not require a central directory, and grows gracefully, through splits of one bucket at a time, to virtually any number of servers. The number of messages per random insertion is one in general, and three in the worst case, regardless of the file size. The number of messages per key search is two in general, and four in the worst case. The file supports parallel operations, e.g., hash joins and scans. Performing a parallel operation on a file of M buckets costs at most 2M + 1 messages, and between 1 and O(log2 Mrounds of messages. We first describle the basic LH* scheme where a coordinator site manages abucket splits, and splits a bucket every time a collision occurs. We show that the average load factor of an LH* file is 65%–70% regardless of file size, and bucket capacity. We then enhance the scheme with load control, performed at no additional message cost. The average load factor then increases to 80–95%. These values are about that of LH, but the load factor for LH* varies more. We nest define LH* schemes without a coordinator. We show that insert and search costs are the same as for the basic scheme. The splitting cost decreases on the average, but becomes more variable, as cascading splits are needed to prevent file overload. Next, we briefly describe two variants of splitting policy, using parallel splits and presplitting that should enhance performance for high-performance applications. All together, we show that LH* files can efficiently scale to files that are orders of magnitude larger in size than single-site files. LH* files that reside in main memory may also be much faster than single-site disk files. Finally, LH* files can be more efficient than any distributed file with a centralized directory, or a static parallel or distributed hash file.
Electrotransfer of Plasmid DNA Encoding an Anti-Mouse Endoglin (CD105) shRNA to B16 Melanoma Tumors with Low and High Metastatic Potential Results in Pronounced Anti-Tumor Effects

Endoglin overexpression is associated with highly proliferative tumor endothelium and also with some tumors, including melanoma. Its targeting has anti-tumor effectiveness, which can also be obtained by RNA interference. The aim of our study was to explore the anti-tumor effectiveness of endoglin silencing by electrotransfer of plasmid DNA encoding short hairpin RNA against endoglin in two murine B16 melanoma variants with different metastatic potential on cells, spheroids and subcutaneous tumors in mice. The results demonstrate that endoglin silencing with gene electrotransfer reduces the proliferation, survival and migration of melanoma cells and also has anti-tumor effectiveness, as the therapy resulted in a high percentage of tumor cures (23% and 58% on B16F1 and B16F10 tumors, respectively). The effectiveness of the therapy correlated with endoglin expression in melanoma cells; in vitro the effects were more pronounced in B16F1 cells, which express more endoglin than B16F10. However, the opposite was observed in vivo in tumors, where there was a higher expression of endoglin and better anti-tumor effectiveness in the B16F10 tumor. In conclusion, targeting endoglin for the treatment of melanoma seems to be a concept worthy of further exploration due to the increased therapeutic effect of the therapy based on simultaneous vascular targeting and its direct effect on tumor cells.
Development of user acceptance model for electronic medical record system

Although electronic medical record (EMR) has already applied in many countries, the global adoption rate of EMR still low. Many previous studies found that the main obstacle of EMR systems adoption is the challenges associated with the user. Medical personnel are the main users in EMR system, so medical personnel have a very important role in determining the success rate of EMR system adoption. Acceptance of EMR by medical personnel is a very important requirement to ensure that the benefits expected from the implementation of EMR system are accomplished. Therefore, it is very important to understand factors influencing the acceptance of medical personnel on EMR system. The purpose of this study was to analyze factors influencing the acceptance of medical personnel on EMR system using the proposed model. The original model is the unified theory of acceptance and use of technology (UTAUT). In this research several factors added to the original model. Additional factors are: motivation to help others, privacy risk and trust. The result this study showed that EMR acceptance by medical personnel is significantly influenced by trust, performance expectancy, privacy risk, social influence, motivation to help others and facilitating conditions.
Changes in older people's living arrangements in Flanders, 1993–98

The living arrangements of older people are changing. An analysis of official registration data (1993–1998) in Flanders, Belgium, shows that while the number of single person households has been increasing, the proportion of people aged 75 or more years living alone has been falling and the proportion living with a spouse or partner increasing. No less than one third of the older people who lived alone in 1993 sustain a one-person household into very old age. It was also found that those who are widowed at a very advanced age change house or move very quickly, women to a greater extent and at younger ages than men. The principal destinations are residential care homes and, to a lesser extent, child's households. Living alone appears to be a decreasingly acceptable option. Since very old people with a disability appear to have an increasing preference for residential care and a lessening preference for co-residence with relatives, these developments have consequences for both informal family care and public social services. Particular attention needs to be paid to men who live alone as a risk-group, and residential care provision requires expansion.
Decentralized adaptive output tracking control of interconnected nonlinear systems with actuator failures

In this paper, a decentralized adaptive backstepping control scheme is proposed to achieve trajectory tracking for a class of nonlinear interconnected systems with stuck type actuator failures. To compensate for the effects of failed actuators, more unknown parameters in addition to original system parameters need to be identified. A damping term is introduced in constructing the stabilizing function in the first step of backstepping design procedure for robustness with respect to the nonlinear interactions between subsystems. It is shown that the global uniform boundedness of all closed-loop signals is ensured with the designed local adaptive controllers. Further, the overall tracking error converges to a residual set ultimately which can be made as small as desired by properly choosing the design parameters.
Automated network games enhancement layer: a proposed architecture

In this paper we present the design of the Automated Network Games Enhancement Layer (ANGEL), a novel architecture for meeting Quality of Service (QoS) requirements of real-time network game traffic across consumer broadband links. Consumer access links can become bottlenecks when faced with heterogeneous network traffic (e.g. simultaneous use of online games and peer-to-peer file sharing) and the online gaming experience can be significantly affected by bottleneck queuing. Implementing QoS on these links provides improvement by reducing latency and jitter. In our approach network servers automatically identify traffic that might benefit from QoS and then trigger provisioning of QoS by signaling network elements such as access routers. By placing intelligence within the network, QoS decisions can be transparently made for the game applications without imposing an additional processing cost at the access link router. Our system uniquely uses machine learning methods to perform traffic classification.