Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group.

CONTEXT Risedronate, a potent bisphosphonate, has been shown to be effective in the treatment of Paget disease of bone and other metabolic bone diseases but, to our knowledge, it has not been evaluated in the treatment of established postmenopausal osteoporosis. OBJECTIVE To test the efficacy and safety of daily treatment with risedronate to reduce the risk of vertebral and other fractures in postmenopausal women with established osteoporosis. DESIGN, SETTING, AND PARTICIPANTS Randomized, double-blind, placebo-controlled trial of 2458 ambulatory postmenopausal women younger than 85 years with at least 1 vertebral fracture at baseline who were enrolled at 1 of 110 centers in North America conducted between December 1993 and January 1998. INTERVENTIONS Subjects were randomly assigned to receive oral treatment for 3 years with risedronate (2.5 or 5 mg/d) or placebo. All subjects received calcium, 1000 mg/d. Vitamin D (cholecalciferol, up to 500 IU/d) was provided if baseline levels of 25-hydroxyvitamin D were low. MAIN OUTCOME MEASURES Incidence of new vertebral fractures as detected by quantitative and semiquantitative assessments of radiographs; incidence of radiographically confirmed nonvertebral fractures and change from baseline in bone mineral density as determined by dual x-ray absorptiometry. RESULTS The 2.5 mg/d of risedronate arm was discontinued after 1 year; in the placebo and 5 mg/d of risedronate arms, 450 and 489 subjects, respectively, completed all 3 years of the trial. Treatment with 5 mg/d of risedronate, compared with placebo, decreased the cumulative incidence of new vertebral fractures by 41 % (95% confidence interval [CI], 18%-58%) over 3 years (11.3 % vs 16.3%; P= .003). A fracture reduction of 65% (95% CI, 38%-81 %) was observed after the first year (2.4% vs 6.4%; P<.001). The cumulative incidence of nonvertebral fractures over 3 years was reduced by 39% (95% CI, 6%-61 %) (5.2 % vs 8.4%; P = .02). Bone mineral density increased significantly compared with placebo at the lumbar spine (5.4% vs 1.1 %), femoral neck (1.6% vs -1.2%), femoral trochanter (3.3% vs -0.7%), and midshaft of the radius (0.2% vs -1.4%). Bone formed during risedronate treatment was histologically normal. The overall safety profile of risedronate, including gastrointestinal safety, was similar to that of placebo. CONCLUSIONS These data suggest that risedronate therapy is effective and well tolerated in the treatment of women with established postmenopausal osteoporosis.
Gap of Understanding on Citizen Participatory Budgeting

In contrary to the expectation of which it has a role to increase the transparency of and the responsibility of self-governing, the participatory budgeting even though aggravates perfunctoriness of participation and local conflicts in Korea. The problems are caused not from the institutional vices of participatory budgeting but from others which each part of people, participating in the budgeting process, have a misunderstanding on the participatory budgeting. Under the consideration that the misunderstandings of citizen and local officials are one of main reasons of a derailing of the participatory budgeting, the study aims to examine empirically the gap between the citizen`s understanding on the participatory budgeting and the official`s, focused on Daeduck-ku, Daejeon.
Corporate governance efficiency and internet financial reporting quality

Purpose - – This paper aims to shed some light on the role of boards of directors in improving internet financial reporting (IFR) quality. Design/methodology/approach - – The empirical study uses a data envelopment analysis (DEA) approach on a sample of 32 French firms belonging to the CAC40 index as of December 2007. Findings - – The empirical results show that 28 percent of the sample firms are located on the efficiency frontier for all IFR components. These firms' boards of directors and their committees seem to act as effective monitors of top executives, which improves the quality of the firm's disclosure policy through, Research limitations/implications - – The study uses only CAC40 companies, which are relatively large and financially healthier than the average French firms, exhibiting diffuse ownership structures, with heavy foreign shareholding, and investing more in communications. This may limit the generalizability of the results to other French listed firms. Originality/value - – The paper extends the literature on corporate governance and voluntary corporate disclosure by investigating the association between board characteristics and IFR quality. It examines the relative performance of the board directors in improving IFR policy.
Capital structure choice: The influence of sentiment in France

The overconfidence bias in relation to investment decisions is well documented in psychology and behavioural finance literature. Less known is that an overconfidence bias also relates to financing decisions. Managers that are overconfident of their firm's future are likely to prefer debt to equity financing. This may lead to increased probability of bankruptcy and higher costs of capital. Empirically it is difficult to measure overconfidence. In this paper we decompose a publicly available measure of industry sentiment into two components: a component common with investor confidence and a component more aligned with manager industry confidence. We find in a sample of French firms that industry confidence and investor confidence are negatively related to leverage and that the unique component of manager industry confidence is positively related to leverage. This provides some support to the theory that overconfident managers prefer debt to equity. In the sample of French firms, the investor confidence component dominates, resulting in an overall negative effect of industry confidence with leverage. This may be due to higher levels of blockholder control and/or a weaker business environment in France relative to other countries.
Meat composition and palatability of Holstein and beef steers as influenced by forage type and protein source.

This experiment determined meat composition and palatability changes resulting from feeding Holstein (HOL) and crossbred beef (XB) steers diets containing corn silage (CS) or alfalfa haylage (AH) (forage type) and soybean meal (SM) or fish meal (FM) (protein source). Fifty-nine steers (30 HOL and 29 XB) were randomly assigned to diet combinations for a 2 x 2 x 2 (breed x forage x protein) factorial arrangement. Steers were fed to a fat-constant end point (fat depth over the longissimus muscle measured by ultrasound: 1.0 cm XB, .6 cm HOL). Proximate and fatty acid analysis and sensory evaluation were conducted on a rib eye roast and steaks, respectively, removed from the left side of each carcass at ribs 9 to 12. Proximate analysis of the longissimus muscle showed no significant difference (P greater than .05) in moisture, protein, or fat content due to breed, forage, or protein treatment. Forage type had no significant effect (P greater than .05) on amount of individual fatty acids found in longissimus muscle. However, total polyunsaturated fatty acids were higher (P greater than .05) for AH than for CS-fed animals. Longissimus muscle from steers fed FM had higher palmitoleic and lower stearic acid contents (both P less than .05) than longissimus muscle from animals fed SM. Muscle from HOL had higher palmitoleic and lower stearic acid contents than that from XB steers (both P less than .05). There was no significant interaction (P greater than .05) of breed with either diet treatment for individual fatty acid contents. (ABSTRACT TRUNCATED AT 250 WORDS)
Thyroid hormones increase Na+-H+ exchange activity in renal brush border membranes.

Na+-H+ exchange activity, i.e., amiloride-sensitive Na+ and H+ flux, in renal proximal tubule brush border (luminal) membrane vesicles was increased in the hyperthyroid rat and decreased in the hypothyroid rat, relative to the euthyroid animal. A positive correlation was found between Na+-H+ exchange activity and serum concentrations of thyroxine (T4) and triiodothyronine (T3). The thyroid status of the animal did not alter amiloride-insensitive Na+ uptake. The rate of passive pH gradient dissipation was higher in membrane vesicles from hyperthyroid rats compared to the rate in vesicles from hypothyroid animals, a result which would tend to limit the increase in Na+ uptake in vesicles from hyperthyroid animals. Na+-dependent phosphate uptake was increased in membrane vesicles from hyperthyroid rats; Na+-dependent D-glucose and L-proline uptakes were not changed by the thyroid status of the animal. The effect of thyroid hormones in increasing the uptake of Na+ in the brush border membrane vesicle is consistent with the action of the hormones in enhancing renal Na+ reabsorption. Further, the regulation of transtubular Na+ flux has now been shown to be concomitant with modulation of the entry of Na+ into the tubular cell across its luminal membrane, mediated by the exchange reaction, and with the previously reported control of the pumping of Na+ out of the cell across its basolateral membrane, mediated by the Na+,K+-ATPase.
An analysis of the factors affecting the turnover intention of non-managerial clerical staff: a Singapore study

This study examines the factors affecting turnover intention and attempts to construct a turnover prediction model. Sixteen demographic, job satisfaction and job attitude factors are considered in the study. From the three-hundred questionnaires administered, a usable response rate of 36 per cent (i.e., 108 usable questionnaires) was obtained. Correlation analyses, t-tests and multiple regression were used to analyse the data. The results show that demographic and job attitude factors are not significantly associated with turnover intention. In contrast, job satisfaction factors affect turnover intention significantly. In particular, satisfaction with career future, company identity, kind of work and financial rewards were found to be statistically significant. These four variables are thus included in the final turnover prediction model.
SmartDisability: A smart system of systems approach to disability

This paper introduces the SmartDisability Framework; a System of Systems to consider mappings between the Disability Types, Range of Movement and Interaction Mediums to produce Technology and Task recommendations. Each element is seen as a constituent system that relies on interaction between the user and technology. The recommended technologies are viewed as independent and operable constituent systems that are networked together to assist people with disability. The SmartDisability conceptual model (based on the familiar disability symbol) and extracts from the initial development stage of the framework are presented. The framework has been populated through a systematic literature review of disability classification, Range of Movement, interaction mediums, `off-the-shelf' technologies and tasks. The framework was augmented by the results of a previously conducted requirements elicitation process, involving surveys and semi-structured interviews, and a user evaluation with head tracking technology. Quality Function Deployment determined the relationships within the framework to ensure that user requirements were fully analysed. The anticipated validation process involving a focus group utilising fictional personas and routes to exploitation (through the development of an application) are also discussed.
Mapping the Future of Family Care: Receipt of Informal Care by Older People with Disabilities in England to 2032

Many long-term care systems in economically developed countries are reliant on informal care. However, in the context of population ageing, there are concerns about the future supply of informal care. This article reports on projections of informal care receipt by older people with disabilities from spouses and (adult) children to 2032 in England. The projections show that the proportions of older people with disabilities who have a child will fall by 2032 and that the extent of informal care in future may be lower than previously estimated. The policy implications, in the context of the Dilnot Commission's report, are explored.
Signaling in a Polluted World: Oxidative Stress as an Overlooked Mechanism Linking Contaminants to Animal Communication

The capacity to communicate effectively with other individuals plays a critical role in the daily life of an individual and can have important fitness consequences. Animals rely on a number of visual and non-visual signals, whose production brings costs to the individual. The theory of honest signaling states that these costs are higher for low than for high-quality individuals, which prevents cheating and makes signals, such as skin and plumage colouration, indicators of individual’s quality or condition. The condition-dependent nature of signals makes them ideally suited as indicators of environmental quality, implying that signal production might be affected by contaminants. In this mini-review article, we have made the point that oxidative stress (OS) is one overlooked mechanism linking exposure to contaminants to signaling because (i) many contaminants can influence the individual’s oxidative balance, and (ii) generation of both visual and non-visual signals is sensitive to oxidative stress. To this end, we have provided the first comprehensive review on the way both non-organic (heavy metals, especially mercury) and organic (persistent organic pollutants) contaminants may influence either OS or sexual signaling. We have also paid special attention to emerging classes of pollutants like brominated flame-retardants and perfluoroalkoxy alkanes in order to stimulate research in this area. We have finally provided suggestions and warnings for future work on the links among OS, sexual signaling and contaminant exposure.
The use of term structure information in the hedging of mortgage‐backed securities

This article examines the importance of term structure variables in the hedging of mortgage‐backed securities (MBS) with Treasury futures. Koutmos, G. , Kroner, K. , and Pericli, A. (1998) find that the optimal hedge ratio is time varying; we determine the effect of yield levels and slopes on this variation. As these variables are closely tied with mortgage refinancing, intuition suggests them to be relevant determinants of the hedge ratio. It was found that a properly specified model of the time varying hedge ratio that excludes the level and slope of the yield curve from the information set would provide similar out‐of‐sample hedging results to a model in which term structure information is included. Thus, both the level of interest rates and the slope of the yield curve are unimportant variables in determining the empirically optimal hedge ratio between MBS and Treasury futures contracts. © 2005 Wiley Periodicals, Inc. Jrl Fut Mark 25:661–678, 2005
Limitations of Cross-Cultural Customer Satisfaction Research and Recommending Alternative Methods

SUMMARY Cross-cultural research in tourism is receiving increasing attention from academics. Little, however, has been done with regard to the assessment of cultural differences in tourist satisfaction. Research in tourism marketing has recognized the need for further research in cross-cultural satisfaction research, and specifically, in equivalence issues regarding the measurement of tourist satisfaction. Consequently, the aim of this conceptual paper is to focus attention on the importance of exploring cross-cultural differences in customer satisfaction research. The principal contributions are three-fold: (1) to emphasize the significance of exploring cross-cultural differences while attempting to measure customer satisfaction in tourism, (2) to recommend alternative research methodology to analyse cross-cultural tourist satisfaction, and also (3) to point out limitations of conducting cross-cultural research in tourist satisfaction from both the theoretical and practical point of view.
Is allergic disease programmed in early life?

Studies of plant and animal development provide ample evidence that environmental influences occurring early in life may produce long-lasting changes in the structure or function of an organism. In recent years, the concept of 'programming' of human development has been vigorously promoted and creatively investigated by the Medical Research Council's Environmental Epidemiology Unit at Southampton, UK, particularly in the context of cardiovascular and respiratory disease [1]. Immunology also provides many examples of biological programming, and it would not be surprising to find evidence that immune function in general, and allergic sensitization in particular, were influenced by events occurring early in hfe. A number of lines of enquiry, including the latest observations by the Southampton team [2], suggest that the environment during the perinatal period may be of considerable importance in the expression of atopy among genetically susceptible individuals.
Screening for control genes in rat global cerebral ischemia using high‐density oligonucleotide array

From conventional relative gene expression analyses (Northern blotting, in situ hybridization, and RT‐PCR), it has been reported that the expression of control genes, such as glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) and β‐actin, used as references may be affected by ischemia. Therefore, we extended searching and evaluation at the mRNA level of transcripts whose expression levels were not changed by cerebral ischemia, using a high‐density oligonucleotide array and statistical analysis in a rat global cerebral ischemia and reperfusion model. We added a hyperthermic factor and localization factor to ischemia and identified transcripts with a stable expression level under conditions even more disadvantageous than ischemia only. Screening of more than 8,000 transcripts with the Rat Genome U34A array yielded 28 transcripts, which we listed and classified according to their expression level. Widely used control genes, GAPDH and β‐actin, were not included, although cyclophilin A was included. In addition, we conducted a functional classification based on gene ontology. Under the functional classification of the 28 transcripts, many genes tended to be associated with metabolism. In conclusion, use of several transcripts is recommended, such as those we identified, as references in the analysis of gene expression in pathological models of ischemia. © 2004 Wiley‐Liss, Inc.
Characterizing cognitive function during relapse in multiple sclerosis

Objective: To characterize neuropsychological (NP) test performance during multiple sclerosis (MS) relapse and recovery. Methods: Clinical status was assessed with NP testing and Expanded Disability Status Scale (EDSS) in 24 relapsing patients, and 24 individually-matched, stable controls. All presented with cognitive symptoms as indicated by patient, clinician or caregiver perceived decline, but were free of optic neuritis, ataxia and upper extremity weakness that could compromise NP testing. The presence of enhancing magnetic resonance imaging (MRI) lesions was considered confirmatory of relapse. Relapsing patients were treated with corticosteroids. NP testing and EDSS were compared to pre-relapse baseline levels, and three-month, post-relapse, follow-up. Results: Analyses revealed significant decline on the Symbol Digit Modalities Test (SDMT) (p=0.005) and worsening on EDSS (p=0.019). Impairment was observed at the point of relapse in cases but not controls. The groups were no longer different at three-month follow-up. The increment of decline on SDMT was 3.5 raw score points, or roughly 6%. Conclusions: This is the first study to assess NP status changes during MS relapse using well established, reliable metrics. The presence of a clinically meaningful event is substantiated by decline in NP testing, observed or reported cognitive change, and in a subset of patients, gadolinium-enhancing MRI lesions.
Ten Square Miles Surrounded By Reality? Materialising Alternative Economies Using Local Currencies

This article examines the success of paper-based alternative currencies in facilitating convivial, sustainable localised economies. Based on fieldwork in the United States, the United Kingdom and Germany, it discusses the capacity of activists to create alternative forms of currency that communicate the organisers’ visions of a localised economy, before examining material practices: for whom do the currencies work, and who struggles to use them? Using insights from a diverse economies perspective, the article argues that we cannot read off the likelihood of an economic actor using the currency from the extent of their local economic embeddedness: economic actors in similar positions respond to the same stimuli in different ways, and local business owners and activists can form productive alliances to develop their shared project. The article concludes by arguing that local currencies should be used more proactively to stimulate new forms of concrete local production to meet locally identified needs.
Filling the gaps: Patterns of formal and informal participation

Industrial relations scholarship has traditionally privileged union forms of employee participation. In more recent years there has been a shift to understand the role of participation in non-union firms. This article develops theory on employee participation through analysis of an Australian case study in the hotel sector. The authors find that formal participation mechanisms are useful and essential for both employees and managers, however formal participation leaves behind gaps which are partially filled with informal voice exchanges between employees and their managers.
The Interplay of Urban Energy Policy and Socio-technical Transitions: The Eco-cities of Graz and Freiburg in Retrospect

The cities of Graz in Austria and Freiburg in Germany have been perceived as ecological model cities since the late 1980s.This is shown by various international awards, press coverage and many visitors from other municipal administrations. Both cities have been well known for their attempts to bring about transitions towards more sustainable and low-carbon energy systems. The comparison of Graz and Freiburg over a period of two decades enables us to study how differing contexts, actor constellations and historic developments shape the transformation of energy systems towards greater sustainability. It is argued that understanding the role of cities for energy transitions requires a detailed examination of the coupled dynamics of socio-technical interactions across the levels of niches, regimes and landscapes on the one hand, and multilevel systems of governance on the other. At these intersections new, although spatially confined, socio-technical constellations of sustainable energy provision may emerge and be stabilised. Nevertheless, empirical evidence shows that it is misleading to conclude that true socio-technical transitions are taking place in these cities, even though a number of foundations for long-term change processes have been laid.