Miracle-dz/UniFAR-FTUs huggingface dataset:
What Matters in Weight Loss? An In-Depth Analysis of Self-Monitoring

Background Using technology to self-monitor body weight, dietary intake, and physical activity is a common practice used by consumers and health companies to increase awareness of current and desired behaviors in weight loss. Understanding how to best use the information gathered by these relatively new methods needs to be further explored. Objective The purpose of this study was to analyze the contribution of self-monitoring to weight loss in participants in a 6-month commercial weight-loss intervention administered by Retrofit and to specifically identify the significant contributors to weight loss that are associated with behavior and outcomes. Methods A retrospective analysis was performed using 2113 participants enrolled from 2011 to 2015 in a Retrofit weight-loss program. Participants were males and females aged 18 years or older with a starting body mass index of ≥25 kg/m2, who also provided a weight measurement at the sixth month of the program. Multiple regression analysis was performed using all measures of self-monitoring behaviors involving weight measurements, dietary intake, and physical activity to predict weight loss at 6 months. Each significant predictor was analyzed in depth to reveal the impact on outcome. Results Participants in the Retrofit Program lost a mean –5.58% (SE 0.12) of their baseline weight with 51.87% (1096/2113) of participants losing at least 5% of their baseline weight. Multiple regression model (R2=.197, P<0.001) identified the following measures as significant predictors of weight loss at 6 months: number of weigh-ins per week (P<.001), number of steps per day (P=.02), highly active minutes per week (P<.001), number of food log days per week (P<.001), and the percentage of weeks with five or more food logs (P<.001). Weighing in at least three times per week, having a minimum of 60 highly active minutes per week, food logging at least three days per week, and having 64% (16.6/26) or more weeks with at least five food logs were associated with clinically significant weight loss for both male and female participants. Conclusions The self-monitoring behaviors of self-weigh-in, daily steps, high-intensity activity, and persistent food logging were significant predictors of weight loss during a 6-month intervention.
Delayed Failure at Intermediate Temperatures (600°–700°C) in Air in Silicon Carbide Multifilament Tows

Unexpected failure of Nicalon/SiC composites is observed under low stresses at intermediate temperatures (600°–800°C) in air. This effect has been designated as a nuisance by a few authors. The lifetime of SiC (Nicalon) multifilament tows is investigated in static fatigue in air at temperatures in the range of 600°–700°C. The various features that have been identified suggest that delayed failure under low stresses results from a slow-crack-growth mechanism. Analysis of acoustic emission data allows the number of failures during the tests to be determined. Scanning electron microscopy examination of tow fracture surfaces allows typical crack patterns to be identified. A model of delayed failure is proposed. The model is based on the Paris law and on the well-known model of subcritical crack growth devised by Davidge et al. for ceramics. The model takes into account the statistics of fiber failure. The slow-crack-growth constants have been determined from stress-rupture data. Finally, the model allows satisfactory description of the lifetime of tows and prediction of the lifetime of Nicalon/SiC minicomposites.
Comparison between shell morphology and genetic diversity in two sympatric lymnaeid snails, vectors of fasciolosis

Species determination of freshwater snails is particularly important in the case of disease vectors. In central France, for example, it has been shown that Galba truncatula (Muller, 1774) and Omphiscola glabra (Muller, 1774), which can be found in sympatry, are intermediate hosts for fasciolosis. Although these two species are distinguishable based on their shell morphology, some snails present in sympatric zones possess shell characteristics that are common to both species, suggesting possible gene flow. To test this hypothesis, we carried out multilocus enzyme electrophoreses on individuals sampled in one zone of sympatry. Our results clearly show that all snails with shell characteristics common to both species are O. glabra. We also note an absence of hybridization between G. truncatula and O. glabra in the study area. Remarkably, we observe a total monomorphism at the six studied loci among individuals of G. truncatula. Similarly, we find a total lack of heterozygotes in the O. glabra sample (with cl.
Inulin-type fructan improves diabetic phenotype and gut microbiota profiles in rats

Background & Aims Accumulating research has addressed the linkage between the changes to gut microbiota structure and type 2 diabetes (T2D). Inulin is one type of soluble dietary fiber that can alleviate T2D. As a prebiotic, inulin cannot be digested by humans, but rather is digested by probiotics. However, whether inulin treatment can benefit the entire gut bacteria community remains unknown. In this study, we evaluated the differences in gut microbiota composition among diabetic, inulin-treated diabetic, normal control, and inulin-treated normal control rats. Methods A diabetic rat model was generated by a high-fat diet and streptozotocin injections (HF/STZ). Inulin was orally administered to normal and diabetic rats. To determine the composition of the gut microbiota, fecal DNA extraction and 16S rRNA gene 454 pyrosequencing were performed. Results We found that inulin treatment reduced fasting blood glucose levels and alleviated glucose intolerance and blood lipid panels in diabetic rats. Additionally, inulin treatment increased the serum glucagon-like peptide-1 (GLP-1) level, reduced serum IL-6 level, Il6 expression in epididymal adipose tissue, and Pepck, G6pc expression in liver of diabetic rats. Pyrophosphate sequencing of the 16s V3–V4 region demonstrated an elevated proportion of Firmicutes and a reduced abundance of Bacteroidetes at the phylogenetic level in diabetic rats compared to normal control rats. The characteristics of the gut microbiota in control and inulin-treated rats were similar. Inulin treatment can normalize the composition of the gut microbiota in diabetic rats. At the family and genus levels, probiotic bacteria Lactobacillus and short-chain fatty acid (SCFA)-producing bacteria Lachnospiraceae, Phascolarctobacterium, and Bacteroides were found to be significantly more abundant in the inulin-treated diabetic group than in the non-treated diabetic group. In addition, inulin-treated rats had a lower abundance of Desulfovibrio, which produce lipopolysaccharide (LPS). The abundance of Lachnospiraceae was negatively correlated with the blood glucose response after a glucose load. Conclusion In summary, diabetic rats have different gut microbiota from control rats. Inulin treatment can alleviate gut microbiota dysbiosis in T2D model rats. Moreover, inulin treatment enhanced serum GLP-1 level to suppress IL-6 secretion and production and hepatic gluconeogenesis, resulted in moderation of insulin tolerance.
A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803

Tumor thymidylate synthase (TS) levels were prospectively evaluated in two adjuvant therapy trials for patients with resected stage II or III colon cancer. Results indicated that high tumor TS levels were associated with improved disease‐free survival and overall survival following adjuvant therapy for colon cancer, although tumor TS expression did not predict benefit of 5‐fluorouracil‐based chemotherapy.
The Neanderthal Meal: A New Perspective Using Faecal Biomarkers

Neanderthal dietary reconstructions have, to date, been based on indirect evidence and may underestimate the significance of plants as a food source. While zooarchaeological and stable isotope data have conveyed an image of Neanderthals as largely carnivorous, studies on dental calculus and scattered palaeobotanical evidence suggest some degree of contribution of plants to their diet. However, both views remain plausible and there is no categorical indication of an omnivorous diet. Here we present direct evidence of Neanderthal diet using faecal biomarkers, a valuable analytical tool for identifying dietary provenance. Our gas chromatography-mass spectrometry results from El Salt (Spain), a Middle Palaeolithic site dating to ca. 50,000 yr. BP, represents the oldest positive identification of human faecal matter. We show that Neanderthals, like anatomically modern humans, have a high rate of conversion of cholesterol to coprostanol related to the presence of required bacteria in their guts. Analysis of five sediment samples from different occupation floors suggests that Neanderthals predominantly consumed meat, as indicated by high coprostanol proportions, but also had significant plant intake, as shown by the presence of 5β-stigmastanol. This study highlights the applicability of the biomarker approach in Pleistocene contexts as a provider of direct palaeodietary information and supports the opportunity for further research into cholesterol metabolism throughout human evolution.
Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for Malignancy

Background Systemic chemotherapies for various malignancies have been shown to significantly, yet transiently, decrease numbers of CD4+ T lymphocytes, a major reservoir for human immunodeficiency virus type 1 (HIV-1) infection. However, little is known about the impact of cytoreductive chemotherapy on HIV-1 reservoir dynamics, persistence, and immune responses. Methods We investigated the changes in peripheral CD4+ T-cell-associated HIV-1 DNA and RNA levels, lymphocyte activation, viral population structure, and virus-specific immune responses in a longitudinal cohort of 15 HIV-1-infected individuals receiving systemic chemotherapy or subsequent autologous stem cell transplantation for treatment of hematological malignancies and solid tumors. Results Despite a transient reduction in CD4+ T cells capable of harboring HIV-1, a 1.7- and 3.3-fold increase in mean CD4+ T-cell-associated HIV-1 RNA and DNA, respectively, were observed months following completion of chemotherapy in individuals on antiretroviral therapy. We also observed changes in CD4+ T-cell population diversity and clonal viral sequence expansion during CD4+ T-cell reconstitution following chemotherapy cessation. Finally, HIV-1 DNA was preferentially, and in some cases exclusively, detected in cytomegalovirus (CMV)- and Epstein-Barr virus (EBV)-responsive CD4+ T cells following chemotherapy. Conclusions Expansion of HIV-infected CMV/EBV-specific CD4 + T cells may contribute to maintenance of the HIV DNA reservoir following chemotherapy.
Nutritional Status of Women and Child Refugees from Syria — Jordan, April–May 2014

As a result of civil war, an estimated 2.8 million refugees have fled Syria and reside in neighboring countries, mainly Lebanon, Turkey, Jordan, and Iraq. The largest Syrian refugee camp in the region is Zaatari camp in Jordan, with approximately 79,000 refugees; another estimated 500,000 Syrian refugees live in Jordanian cities, towns, and villages, mostly in the capital (Amman) and in four northern governorates (Irbid, Mafraq, Jarash, and Zarqa). Although all registered refugees in Jordan receive food vouchers from the World Food Programme (WFP) and vulnerable refugees receive cash assistance from the United Nations High Commissioner for Refugees (UNHCR) and nongovernmental organizations, the nutritional status of some refugees might be compromised because of dislocation, lack of income, and limited access to nutritious foods. To assess the nutritional status of Syrian refugees, UNHCR, WFP, the United Nations Children's Fund (UNICEF), Medair International (a nongovernmental organization), and CDC, in collaboration with the United Nations Population Fund and the World Health Organization (WHO), conducted cross-sectional, population-representative cluster surveys in Zaatari camp and among refugees residing in the host community. The surveys were conducted during April-May 2014 with the principal objective of assessing nutritional status of refugee children aged 6-59 months and nonpregnant women of reproductive age (15-49 years). Preliminary findings indicated a high prevalence of anemia in Zaatari camp among both children and women (48.4% and 44.8%, respectively). Nutrition policies aimed at ensuring optimal child and maternal micronutrient status and addressing the underlying risk factors for anemia are likely to result in improved health outcomes and a reduction in anemia.
Statistical study of the equatorial F2 layer critical frequency at Ouagadougou during solar cycles 20, 21 and 22, using Legrand and Simon’s classification of geomagnetic activity

This paper presents the statistical analysis of the diurnal variations of the F layer at the equatorial station of Ouagadougou (Lat: 12.4� N; Long: 358.5� E; dip: 5.9� ) from 1966 to 1998 (=> ~11 680 days). We consider three main factors of variability: (1) the season (spring, summer, autumn and winter), (2) the phase of the sunspot cycle (ascending, maximum, descending and minimum) and (3) the geomagnetic activity classified by Legrand and Simon in four groups: slow solar wind, high solar wind streams, fluctuating solar wind and shock activity. We easily identify the influence of the solar wind speed and shock activity on the diurnal pattern of the F layer. Shock and recurrent activities tend to enhance or diminish the morning or afternoon maximum of the F2 layer critical frequency. The difference of the diurnal foF2 variation during the increasing and decreasing phases of the sunspot solar cycle is explained by different solar wind regimes. The slow solar wind dominates during the increasing phase of the sunspot cycle and the fluctuating solar wind dominates during the decreasing phase of the sunspot cycle. This paper demonstrates that it is possible using a large database, to bring up significant morphologies of the diurnal variation of the foF2 critical frequency as a function of (1) different solar events such as quiet solar wind, fluctuating wind, recurrent high stream wind and Coronal Mass Ejections (CMEs); (2) solar cycle phases and (3) seasons. It is an approach directly connecting the critical frequency of the F2 layer to the solar parameters.
Effects of Cranioplasty on Cerebral Blood Flow Following Decompressive Craniectomy: A Systematic Review of the Literature

BACKGROUND Cranioplasty after decompressive craniectomy (DC) is routinely performed for reconstructive purposes and has been recently linked to improved cerebral blood flow (CBF) and neurological function. OBJECTIVE To systematically review all available literature to evaluate the effect of cranioplasty on CBF and neurocognitive recovery. METHODS A PubMed, Google Scholar, and MEDLINE search adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines included studies reporting patients who underwent DC and subsequent cranioplasty in whom cerebral hemodynamics were measured before and after cranioplasty. RESULTS The search yielded 21 articles with a total of 205 patients (range 3-76 years) who underwent DC and subsequent cranioplasty. Two studies enrolled 29 control subjects for a total of 234 subjects. Studies used different imaging modalities, including CT perfusion (n = 10), Xenon-CT (n = 3), single-photon emission CT (n = 2), transcranial Doppler (n = 6), MR perfusion (n = 1), and positron emission tomography (n = 2). Precranioplasty CBF evaluation ranged from 2 days to 6 months; postcranioplasty CBF evaluation ranged from 7 days to 6 months. All studies demonstrated an increase in CBF ipsilateral to the side of the cranioplasty. Nine of 21 studies also reported an increase in CBF on the contralateral side. Neurological function improved in an overwhelming majority of patients after cranioplasty. CONCLUSION This systematic review suggests that cranioplasty improves CBF following DC with a concurrent improvement in neurological function. The causative impact of CBF on neurological function, however, requires further study.
Lung Cancer Risk and Residential Exposure to Air Pollution: A Korean Population-Based Case-Control Study

Purpose To investigate the association between long-term exposure to ambient air pollution and lung cancer incidence in Koreans. Materials and Methods This was a population-based case-control study covering 908 lung cancer patients and 908 controls selected from a random sample of people within each Korean province and matched according to age, sex, and smoking status. We developed land-use regression models to estimate annual residential exposure to particulate matter (PM10) and nitrogen dioxide (NO2) over a 20-year exposure period. Logistic regression was used to estimate odds ratios (ORs) and their corresponding 95% confidence intervals (CI). Results Increases in lung cancer incidence (expressed as adjusted OR) were 1.09 (95% CI: 0.96−1.23) with a ten-unit increase in PM10 (µg/m3) and 1.10 (95% CI: 1.00−1.22) with a ten-unit increase in NO2 (ppb). Tendencies for stronger associations between air pollution and lung cancer incidence were noted among never smokers, among those with low fruit consumption, and among those with a higher education level. Air pollution was more strongly associated with squamous cell and small cell carcinomas than with adenocarcinoma of the lung. Conclusion This study provides evidence that PM10 and NO2 contribute to lung cancer incidence in Korea.
Spatial and temporal analysis of surface hardness across a third-generation artificial turf pitch over a year

Despite the potentially negative effects on play performance and safety, little is currently known about the spatial and temporal variability in the properties of artificial turf pitches. The primary purpose of this study was to quantify the spatial and temporal variations in surface hardness across a 5-year-old third-generation artificial turf pitch over full year cycle. The secondary purpose was to investigate the key variables that contributed to these variations in surface hardness using a correlation approach. Surface hardness (2.25 kg Clegg impact hammer, average of drops 2–5), ground temperature and infill depth were measured at 91 locations across the third-generation artificial turf pitch in 13-monthly test sessions from August 2011 to August 2012 inclusive. For each month, rainfall in the 24 h prior to testing and pitch usage statistics were also obtained. Shockpad thickness was obtained from measurements taken when the carpet was replaced in 2007. Spatial and temporal variations were assessed using robust statistical measures while Spearman correlation was used to assess the contributions of the secondary variables to surface hardness variability. The results indicated that spatial variation in surface hardness exceeded temporal variation; the former demonstrated a median absolute deviation of 12 ± 1 G across the pitch in any test session while the median absolute deviation for the latter was only 4 ± 2 G across the 13 test sessions. Spatial variation in surface hardness was moderately correlated with shockpad thickness and weakly correlated with infill depth (both negative). These results reinforce the importance of monitoring spatial and temporal variations in play performance variables for third-generation surfaces as well as providing support for the role of maintenance in minimising the spatial variation.
The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation

Natural killer T (NKT) cells are activated by lipid antigens presented by CD1d molecules and represent a major lymphocyte subset of the liver. NOD.c3c4 mice spontaneously develop biliary inflammation in extra‐ and intrahepatic bile ducts. We demonstrated by flow cytometry that invariant NKT (iNKT) cells were more abundant in the thymus, spleen, and liver of NOD.c3c4 mice compared to NOD mice. iNKT cells in NOD.c3c4 mice displayed an activated phenotype. Further, NOD and NOD.Cd1d‐/‐ mice were irradiated and injected with NOD.c3c4 bone marrow, and injection of NOD.c3c4 bone marrow resulted in biliary infiltrates independently of CD1d expression in recipient mice. Activation or blocking of NKT cells with α‐galactosylceramide or anti‐CD1d antibody injections did not affect the biliary phenotype of NOD.c3c4 mice. NOD.c3c4. Cd1d‐/‐ mice were generated by crossing NOD.Cd1d‐/‐ mice onto a NOD.c3c4 background. NOD.c3c4. Cd1d‐/‐ and NOD.c3c4 mice developed the same extent of biliary disease. This study demonstrates that iNKT cells are more abundant and activated in the NOD.c3c4 model. The portal inflammation of NOD.c3c4 mice can be transferred to irradiated recipients, which suggests an immune‐driven disease. Our findings imply that NKT cells can potentially participate in the biliary inflammation, but are not the primary drivers of disease in NOD.c3c4 mice.
How patients and clinicians make meaning of physical suffering in mental health evaluations

Clinicians in community mental health settings frequently evaluate individuals suffering from physical health problems. How patients make meaning of such “comorbidity” can affect mental health in ways that may be influenced by cultural expectations and by the responses of clinicians, with implications for delivering culturally sensitive care. A sample of 30 adult mental health intakes exemplifying physical illness assessment was identified from a larger study of patient–provider communication. The recordings of patient–provider interactions were coded using an information checklist containing 21 physical illness items. Intakes were analyzed for themes of meaning making by patients and responses by clinicians. Post-diagnostic interviews with these patients and clinicians were analyzed in similar fashion. Clinicians facilitated disclosures of physical suffering to varying degrees and formulated them in the context of the culture of mental health services. Patients discussed their perceptions of what was at stake in their experience of physical illness: existential loss, embodiment, and limits on the capacity to work and on their sense of agency. The experiences of physical illness, mental health difficulties, and social stressors were described as mutually reinforcing. In mental health intakes, patients attributed meaning to the negative effects of physical health problems in relation to mental health functioning and social stressors. Decreased capacity to work was a particularly salient concern. The complexity of these patient–provider interactions may best be captured by a sociosomatic formulation that addresses the meaning of physical and mental illness in relation to social stressors.
Word count : 2891 1 2 Reduction of the anticholinergic burden makes it possible to decrease behavioral and 3 psychological symptoms of dementia

43 OBJECTIVES: The aim of this study was to evaluate the impact of a reduction of the 44 anticholinergic burden (AB) on the frequency and severity of behavioral and psychological 45 symptoms of dementia (BPSD), and their repercussion on the care team (occupational 46 disruptiveness). 47 DESIGN: prospective, single center study. 48 SETTING: acute care unit for Alzheimer’s disease (AD) and related disorders. 49 PARTICIPANTS: elderly subjects with dementia presenting BPSD (N = 125, mean age 84.4). 50 MEASUREMENTS: The reduction of the AB was evaluated by the Anticholinergic Cognitive 51 Burden Scale. BPSD were evaluated by the NPI-NH (Neuropsychiatric Inventory-Nursing Home) 52 scale. The effect of the reduction of the AB on the BPSD was studied using logistic regression 53 adjusting for the variables of the comprehensive geriatric assessment. 54 RESULTS: Seventy-one subjects (56.8%) presenting with probable AD, 32 (25.6%) mixed 55 dementia (AD and vascular), 17 (13.6%) vascular dementia, and 5 (4.0%) Lewy body dementia 56 were included. Reducing the AB by at least 20% enabled a significant reduction in the frequency 57