Miracle-dz/UniFAR-FTUs huggingface dataset:
Action in action research: Elaborating the concepts of action, roles and dilemmas in a public e-service development project

Purpose The purpose of this paper is to elaborate on the concept of action by addressing actions and roles in the practice of action research, illustrated by dilemmas in an action research project on information systems development in public sector. The main ambition with action research is being able to solve organisational problems through intervention and to contribute to scientific knowledge. The main emphasis has so far been on the “research part”. Here the authors focus on the “action part” of action research to generate rigorous research, to solve local problems and to deal with evident dilemmas in action research. Design/methodology/approach This is a qualitative case study. The empirical illustrations of this paper originate from an action research project that focused the two e-service development initiatives analysed below. The analysis is structured using key aspects and phases proposed by Avison et al. (2001). As a result of the analysis, the concept of action is elaborated. The action elements action, actor, motive, space and time are analysed together with different roles. This goes beyond the existing action research literature. Findings The conclusions show that there is a need to understand actions and roles within action research projects – not separating action from research. Research is also seen as action. The practice of action research is also discussed as context-bounded interactive social action: action research as a recurrent, interactive and dynamic activity. It is also identified that the understanding of roles, actions and interaction can help handle dilemmas in action research. Research Limitations/implications The authors contribute to the body of knowledge concerning action research in the information systems research field and in general by exploring the need to study the concept of action (e.g. situations and elements), to be explicit concerning the different phases, roles and responsibilities and management of different dilemmas in action research. A limitation of this study is that the inter-organisational development character in this study adds an extra dimension into the practice of actions research only partially highlighted. Another limitation is focus on public agencies. However, this is not critical for the results on action elements and the action research dilemmas that are studied. Practical Implications The understanding of roles, actions and interaction can solve the dilemmas and challenges linked to the practice of action research in the information systems field, but such understanding can help discover and handle dilemmas in action research. Originality/value The originality in this research is an illustration of and a perspective of action research as a context-bounded interactive social action: action research as a recurrent, interactive and dynamic activity. The value is that this knowledge can help handle dilemmas in action research.
Snout Shape in Extant Ruminants

Snout shape is a prominent aspect of herbivore feeding ecology, interacting with both forage selectivity and intake rate. Previous investigations have suggested ruminant feeding styles can be discriminated via snout shape, with grazing and browsing species characterised by ‘blunt’ and ‘pointed’ snouts respectively, often with specification of an ‘intermediate’ sub-grouping to represent ambiguous feeding styles and/or morphologies. Snout shape morphology is analysed here using a geometric morphometric approach to compare the two-dimensional profiles of the premaxilla in ventral aspect for a large sample of modern ruminant species, for which feeding modes are known from secondary criteria. Results suggest that, when browsing and grazing ruminants are classified ecologically based on a range of feeding style indicators, they cannot be discriminated unambiguously on the basis of snout profile shape alone. Profile shapes in our sample form a continuum with substantial overlap between groupings and a diverse range of morphologies. Nevertheless, we obtained an 83.8 percent ratio of correct post hoc feeding style categorisations based on the proximity of projected profile shapes to group centroids in the discriminant space. Accordingly, this procedure for identifying species whose feeding strategy is ‘unknown’ can be used with a reasonable degree of confidence, especially if backed-up by additional information. Based on these results we also refine the definitions of snout shape varieties, taking advantage of the descriptive power that geometric morphometrics offers to characterize the morphological disparities observed. The shape variance exhibited by both browsing and grazing ruminants corresponds strongly to body mass, providing further evidence for an interaction between snout shape, feeding style, and body size evolution. Finally, by exploring the role of phylogenetic similarity in snout shape, we find a slight increase in successful categorisation when repeating the analysis with phylogenetic control on the geometric profiles.
CPU inheritance scheduling

Traditional processor scheduling mechanisms in operating systems are fairly rigid, often supportingonly one fixed scheduling policy, or, at most, a few “scheduling classes” whose implementations are closely tied together in the OS kernel. This paper presents CPU inheritance scheduling, a novel processor scheduling framework in which arbitrary threads can act as schedulers for other threads. Widely different scheduling policies can be implemented under the framework, and many different policies can coexist in a single system, providing much greater scheduling flexibility. Modular, hierarchical control can be provided over the processor utilization of arbitrary administrative domains, such as processes, jobs, users, and groups, and the CPU resources consumed can be accounted for and attributed accurately. Applications, as well as the OS, can implement customized local scheduling policies; the framework ensures that all the different policies work together logically and predictably. As a side effect, the framework also cleanly addresses priority inversion by providing a generalized form of priority inheritance that automatically works within and among diverse scheduling policies. CPU inheritance scheduling extends naturally to multiprocessors, and supports processor management techniques such as processor affinity[29] and scheduler activations[3]. We show that this flexibility can be provided with acceptable overhead in typical environments, depending on factors such as context switch speed and frequency.
Bactericidal activity of amoxicillin against non-susceptible Streptococcus pneumoniae in an in vitro pharmacodynamic model simulating the concentrations obtained with the 2000/125 mg sustained-release co-amoxiclav formulation.

OBJECTIVES To investigate the bactericidal activity against Streptococcus pneumoniae of simulated amoxicillin serum concentrations obtained in humans after 2000/125 mg sustained-release (SR) and 875/125 mg co-amoxiclav administered twice and three times a day, respectively. METHODS An in vitro computerized pharmacodynamic simulation was carried out and colony counts were determined over 24 h. Ten strains non-susceptible to amoxicillin (four of them exhibiting an MIC of 4 mg/L, five strains with an MIC of 8 mg/L and one strain with an MIC of 16 mg/L) were used. RESULTS With amoxicillin 2000 mg, an initial inoculum reduction >99.99% was obtained for strains with an MIC of 4 mg/L, > or =99% for strains with an MIC of 8 mg/L and 70.6% for the strain with an MIC of 16 mg/L at 24 h sampling time. At this sampling time, no reduction of initial inocula was obtained with amoxicillin 875 mg/8 h for two of the four strains with an MIC of 4 mg/L, three of the five strains with an MIC of 8 mg/L or for the strain with an MIC of 16 mg/L. CONCLUSIONS The new co-amoxiclav 2000/125 mg SR formulation appears to offer advantages versus previous formulations with respect to bactericidal activity against current amoxicillin non-susceptible strains.
Business Intelligence & Analytics and Decision Quality - Insights on Analytics Specialization and Information Processing Modes

Leveraging the benefits of business intelligence and analytics (BI&A) and improving decision quality does not only depend on establishing BI&A technology, but also on the organization and characteristics of decision processes. This research investigates new perspectives on these decision processes and establishes a link between characteristics of BI&A support and decision makers’ modes of information processing behavior, and how these ultimately contribute to the quality of decision outcomes. We build on the heuristic–systematic model (HSM) of information processing, as a central explanatory mechanism for linking BI&A support and decision quality. This allows us examining the effects of decision makers’ systematic and heuristic modes of information processing behavior in decision making processes. We further elucidate the role of analytics experts in influencing decision makers’ utilization of analytic advice. The analysis of data from 136 BI&A-supported decisions reveals how high levels of analytics elaboration can have a negative effect on decision makers’ information processing behavior. We further show how decision makers’ systematic processing contributes to decision quality and how heuristic processing restrains it. In this context we also find that trustworthiness in the analytics expert plays an important role for the adoption of analytic advice.
Counter-fitting Word Vectors to Linguistic Constraints

In this work, we present a novel counter-fitting method which injects antonymy and synonymy constraints into vector space representations in order to improve the vectors' capability for judging semantic similarity. Applying this method to publicly available pre-trained word vectors leads to a new state of the art performance on the SimLex-999 dataset. We also show how the method can be used to tailor the word vector space for the downstream task of dialogue state tracking, resulting in robust improvements across different dialogue domains.
Time-Resolved Photoluminescence Spectroscopy and Imaging: New Approaches to the Analysis of Cultural Heritage and Its Degradation

Applications of time-resolved photoluminescence spectroscopy (TRPL) and fluorescence lifetime imaging (FLIM) to the analysis of cultural heritage are presented. Examples range from historic wall paintings and stone sculptures to 20th century iconic design objects. A detailed description of the instrumentation developed and employed for analysis in the laboratory or in situ is given. Both instruments rely on a pulsed laser source coupled to a gated detection system, but differ in the type of information they provide. Applications of FLIM to the analysis of model samples and for the in-situ monitoring of works of art range from the analysis of organic materials and pigments in wall paintings, the detection of trace organic substances on stone sculptures, to the mapping of luminescence in late 19th century paintings. TRPL and FLIM are employed as sensors for the detection of the degradation of design objects made in plastic. Applications and avenues for future research are suggested.
Comparison of Three Motion Cueing Algorithms for Curve Driving in an Urban Environment

Research on new automotive systems currently relies on car driving simulators, as they are a cheaper, faster, and safer alternative to tests on real tracks. However, there is increasing concern about the motion cues provided in the simulator and their influence on the validity of these studies. Especially for curve driving, providing large sustained acceleration is difficult in the limited motion space of simulators. Recently built simulators, such as Desdemona, offer a large motion space showing great potential as automotive simulators. The goal of this research is: first, to develop a motion drive algorithm for urban curve driving in the Desdemona simulator; and second, to evaluate the solution through a simulator driving experiment. The developed algorithm, the one-to-one yaw algorithm, is compared to a classical washout algorithm (adapted to the Desdemona motion space) and a control condition where only road rumble is provided. Results show that regarding lateral motion, the absence of cues in the rumble condition is preferred over the presence of false cues in the classical algorithm. No motion seems to be favored over bad motion. In terms of longitudinal motion, the one-to-one yaw and the classical algorithm are voted better than the rumble condition, showing that the addition of motion cues is beneficial to the simulation of braking. In a general way, the one-to-one yaw algorithm is classified better than the other two algorithms.
Intensity of the Vaccine-Elicited Immune Response Determines Tumor Clearance

Tumor Ag-specific vaccines used for cancer immunotherapy can generate specific CD8 responses detectable in PBMCs and in tumor-infiltrating lymphocytes. However, human studies have shown that detection of a systemic vaccine-induced response does not necessarily correlate with the occasional instances of tumor rejection. Because this discrepancy might partially be attributable to the genetic heterogeneity of human cancers, as well as to the immunosuppressive effects of previous treatments, we turned to a mouse model in which these variables could be controlled to determine whether a relationship exists between the strength of vaccine-induced immune responses and tumor rejection. We challenged mice with the β-galactosidase (β-gal)-expressing tumor cells, C25.F6, vaccinated them with β-gal-carrying viral vectors, and used quantitative RT-PCR to measure the vaccine-induced immune response of splenocytes directly ex vivo. We found that the strength of the response increased with increasing doses of β-gal-carrying vector and/or upon boosting with a heterologous β-gal-carrying virus. Most importantly, we found that the strength of the detected immune response against this foreign Ag strongly correlated with reduction in the number of lung metastases. The results from this mouse model have major implications for the implementation of tumor vaccines in humans.
Monitoring of BCR-ABL levels in chronic myeloid leukemia patients treated with imatinib in the chronic phase - the importance of a major molecular response

Background Real time PCR has become the most common technique to monitor BCR-ABL transcript levels of patients treated with kinase inhibitors. The aim of this study was to evaluate BCR-ABL levels of chronic myeloid leukemia patients treated with imatinib in the chronic phase and correlate the response to therapy and event-free survival. Methods BCR-ABL levels were measured in peripheral blood cell samples using Real time PCR at diagnosis and then every 3 months after starting therapy with imatinib. Major molecular response was defined as a three-log reduction from the standardized baseline value. Major molecular response values were adjusted to international scale using a conversion factor of 1.19. The results are reported as a BCR-ABL/ABL ratio (%). Results Hematological, major cytogenetic and complete cytogenetic responses were achieved by 57 (95%), 45 (75%) and 38 (63%) patients, respectively. Twenty-four out of sixty patients achieved a major molecular response (40%) in a median time of 8.5 months. Overall survival and event free survival were higher for patients with (100%) versus patients without (77%) a complete cytogenetic response (p-value = 0.01) at 48 months. Patients with complete cytogenetic response and major molecular response had a higher event free survival compared to patients with complete cytogenetic response but without major molecular response (p-value = 0.007). Conclusion In conclusion, the prognostic impact of achieving complete cytogenetic response and a major molecular response and also the importance of molecular monitoring in the follow-up of chronic myeloid leukemia patients were demonstrated.s
Assessing Latrine Use in Rural India: A Cross-Sectional Study Comparing Reported Use and Passive Latrine Use Monitors

Although large-scale programs, like India's Total Sanitation Campaign (TSC), have improved latrine coverage in rural settings, evidence suggests that actual use is suboptimal. However, the reliability of methods to assess latrine use is uncertain. We assessed the reliability of reported use, the standard method, by comparing survey-based responses against passive latrine use monitors (PLUMs) through a cross-sectional study among 292 households in 25 villages in rural Odisha, India, which recently received individual household latrines under the TSC. PLUMs were installed for 2 weeks and householders responded to surveys about their latrine use behavior. Reported use was compared with PLUM results using Bland–Altman (BA) plots and concordance statistics. Reported use was higher than corresponding PLUM-recorded events across the range of comparisons. The mean reported “usual” daily events per household (7.09, 95% confidence interval [CI] = 6.51, 7.68) was nearly twice that of the PLUM-recorded daily average (3.62, 95% CI = 3.29, 3.94). There was poor agreement between “usual” daily latrine use and the average daily PLUM-recorded events (ρc = 0.331, 95% CI = 0.242, 0.427). Moderate agreement (ρc = 0.598, 95% CI = 0.497, 0.683) was obtained when comparing daily reported use during the previous 48 hours with the average daily PLUM count. Reported latrine use, though already suggesting suboptimal adoption, likely exaggerates the actual level of uptake of latrines constructed under the program. Where reliance on self-reports is used, survey questions should focus on the 48 hours prior to the date of the survey rather than asking about “usual” latrine use behavior.
Spelling Difficulties in School-Aged Girls With Attention-Deficit/Hyperactivity Disorder

Writing difficulties are common among children with attention-deficit/hyperactivity disorder (ADHD), but the nature of these difficulties has not been well studied. Here we relate behavioral, psycholinguistic, cognitive (memory/executive), and graphomotor measures to spelling skills in school-age girls with ADHD (n = 30) and an age-matched group of typically developed spellers (TYPSP, n = 35). When subdividing the ADHD group into those with poor (ADHDPSP, n = 19) and typical spelling (ADHDTYPSP, n = 11), the two subgroups did not differ with regard to inattentive or hyperactive–impulsive symptom severity according to parent or teacher ratings. Both ADHD subgroups also had equally severe difficulties in graphomotor control–handwriting and (parent ratings of) written expression as compared to the TYPSP group. In contrast, ADHDPSP had problems relative to ADHDTYPSP and TYPSP on phonological and orthographic recoding (choice tasks) and verbal memory (digit span) and were more likely to make commissions on a continuous performance task (CPT). Further analyses using the collapsed ADHD group showed that both digit span and the presence of CPT commissions predicted spelling performance independently of each other. Finally, results showed that phonological recoding skills mediated the association between digit span and spelling performance in ADHD. Theoretical and educational implications are discussed.
Filter Optimization for Carrier-Frequency- and Timing-Offset in Universal Filtered Multi-Carrier Systems

Universal Filtered Multi-Carrier (UFMC) is a novel multi-carrier modulation technique which can be seen as a generalization of filtered OFDM and filter bank based multicarrier (FBMC-FMT). Being a candidate waveform technology for 5G wireless systems, it combines the simplicity of OFDM with the advantages of FBMC. The FIR-filter, used in UFMC to filter a group of subcarriers, is a key design parameter to gain more robustness in relaxed synchronization conditions, i.e. timefrequency misalignment. It was shown in previous work that very significant SIR improvement can be achieved for UFMC by optimizing the FIR-filter, taking carrier frequency offset into account. In this paper, we optimize the FIR-filter design in UFMC by taking both carrier frequency and timing offset into account in an uplink multi-user FDMA scenario. From the simulation results, up to 3.6 dB SIR improvement can be achieved with the optimized FIR filter compared to UFMC with non-optimized Dolph-Chebyshev filter and 15.1 dB SIR gain against classical CP-OFDM system respectively, provided that the normalized carrier frequency and timing offset are uniformly distributed in the interval ±5%.
An Initial Timing Offset Estimation Method for OFDM Systems in Rayleigh Fading Channel

An initial timing offset estimation method for orthogonal frequency-division multiplexing (OFDM) systems is proposed. Conventional preamble-based synchronization methods result in performance degradation due to the time variation in the power delay profile of the channel. We propose a simple but efficient synchronization method using a specifically designed preamble. The performance of the proposed estimator is evaluated by computer simulations. The simulation results show that the proposed estimator has a significantly smaller mean squared error (MSE) than other estimators even in the fast varying channel.
A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein

We have identified three yeast genes, KES1, HES1 and OSH1, whose products show homology to the human oxysterol binding protein (OSBP). Mutations in these genes resulted in pleiotropic sterol‐related phenotypes. These include tryptophan‐transport defects and nystatin resistance, shown by double and triple mutants. In addition, mutant combinations showed small but apparently cumulative reductions in membrane ergosterol levels. The three yeast genes are also functionally related as overexpression of HES1 or KES1 alleviated the tryptophan‐transport defect in kes1Δ or osh1Δ mutants, respectively. Our study implicates this new yeast gene family in ergosterol synthesis and provides comparative evidence of a role for human OSBP in cholesterol synthesis.
MULTI-DEGREE SMOOTHER FOR LOW POWER TESTABLE DIGITAL SYSTEM DESIGN USING BS-LFSR AND SCAN-CHAIN ORDERING TECHNIQUES

-Testing of digital VLSI circuits entails many challenges as a consequence of rapid growth of semiconductor manufacturing technology and the unprecedented levels of design complexity and the gigahertz range of operating frequencies. These challenges include keeping the average and peak power dissipation and test application time within acceptable limits. This dissertation proposes techniques to addresses these challenges during test. The first proposed technique, called bit-swapping LFSR (BS-LFSR), uses new observations concerning the output sequence of an LFSR to design a low-transition test-pattern-generator (TPG) for test-per-clock built-in self-test (BIST) to achieve reduction in the overall switching activity in the circuit-under-test (CUT). The obtained results show up to 28% power reduction for the proposed design, and up-to 63% when it is combined with another established technique. The proposed BS-LFSR is then extended for use in test-per-scantest vectors show up to 60%reduction in average power consumption. The BS-LFSR is then extended further to act as a multi-degree smoother for test patterns generated by conventional LFSRs before applying them to the CUT. Experimental results show up to 55% reduction in average power. Another technique that aims to reduce peak power in scan-based BIST is presented. The new technique uses a two-phase scan-chain ordering algorithm to reduce average and peak power in scan and capture cycles. Experimental results show up to 65% and 55% reduction in average and peak power, respectively. Finally, a technique that aims to significantly increase the fault coverage in test-Per scan BIST, while keeping the test-application time short, is proposed. The results obtained show a significant improvement in fault coverage and test application time compared with other techniques.