Miracle-dz/UniFAR-FTUs huggingface dataset:
Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR.

Selective inhibition of type 2 5alpha-reductase has been shown to be efficacious in the treatment of benign prostatic hyperplasia. Pharmacokinetic and pharmacodynamic results are reported of treatment with a potent inhibitor of both 5alpha-reductase isozymes, GG745, in rats, dogs and men. In the rat, GG745 has a similar effect on DHT-driven prostatic growth as finasteride, another dual 5alpha-reductase inhibitor in this species. However, GG745 appears to be more potent in the rat, a result that likely reflects the greater inherent potency and terminal half-life of GG745 (14 hr) compared with that of finasteride (1 hr). These pharmacokinetic differences are also maintained in the dog (65 and 4 hr for GG745 and finasteride, respectively). From these results, the literature, and in vitro studies, we estimated doses of GG745 likely to prove efficacious in reducing DHT levels in man. These estimated values were predictive of single-dose effects of GG745 in man. Results from single-dose evaluations in man indicate that GG745 has a terminal half-life of approximately 240 hr, and single doses of >10 mg decreased DHT levels significantly more than did single 5-mg doses of finasteride. These data support the hypothesis that a molecule (GG745) that effectively inhibits both 5alpha-reductases will lower serum DHT levels significantly more than a molecule that inhibits only a single 5alpha-reductase isozyme (e.g., finasteride, a selective inhibitor of the type 2 enzyme in man).
From the Visual book to the WEB book: the importance of design

This paper presents the results of two studies into electronic book production. The Visual book study explored the importance of the visual component of the book metaphor for the production of more effective electronic books, while the WEB book study took the findings of the Visual book and applied them to the production of books for publication on the World Wide Web (WWW). Both studies started from an assessment of which kinds of paper book are more suitable for translation into electronic form. Both also identified publications which are meant to be used for reference rather than those which are read sequentially, and usually in their entirety. This group includes scientific publications and textbooks which were both used as the target group for the Visual book and the WEB book experiments. In this paper we discuss the results of the two studies and how they could influence the design and production of more effective electronic books.
Using MODIS Data to Predict Regional Corn Yields

A simple approach was developed to predict corn yields using the MoDerate Resolution Imaging Spectroradiometer (MODIS) data product from two geographically separate major corn crop production regions: Illinois, USA and Heilongjiang, China. The MOD09A1 data, which are eight-day interval surface reflectance data, were obtained from day of the year (DOY) 89 to 337 to calculate the leaf area index (LAI). The sum of the LAI from early in the season to a given date in the season (end of DOY (EOD)) was well fitted to a logistic function and represented seasonal changes in leaf area duration (LAD). A simple phenology model was derived to estimate the dates of emergence and maturity using the LAD-logistic function parameters b1 and b2, which represented the rate of increase in LAI and the date of maximum LAI, respectively. The phenology model predicted emergence and maturity dates fairly well, with root mean square error (RMSE) values of 6.3 and 4.9 days for the validation dataset, respectively. Two simple linear regression models (YP and YF) were established using LAD as the variable to predict corn yield. The yield model YP used LAD from predicted emergence to maturity, and the yield model YF used LAD for a predetermined period from DOY 89 to a particular EOD. When state/province corn yields for the validation dataset were predicted at DOY 321, near completion of the corn harvest, the YP model, including the predicted phenology, performed much better than the YF model, with RMSE values of 0.68 t/ha and 0.66 t/ha for Illinois and Heilongjiang, respectively. The YP model showed similar or better performance, even for the much earlier pre-harvest yield prediction at DOY 257. In addition, the model performance showed no difference between the two study regions with very different climates and cultivation methods, including cultivar and irrigation management. These results suggested that the approach described in this paper has potential for application to relatively wide agroclimatic regions with different cultivation methods and for extension to the other crops. However, it needs to be examined further in tropical and sub-tropical regions, which are very different from the two study regions with respect to agroclimatic constraints and agrotechnologies.
Results of a randomized phase II trial of amrubicin (AMR) versus topotecan (Topo) in patients with extensive-disease small cell lung cancer (ED-SCLC) sensitive to first-line platinum-based chemotherapy.

8028 Background: SCLC presents as ED-SCLC in 60%-70% of patients (pts). AMR, a synthetic anthracycline, is approved for these pts in Japan. We compare the efficacy and safety of single-agent AMR vs topotecan in non-Japanese pts with 2nd-line ED-SCLC sensitive to 1st-line platinum-based chemotherapy. METHODS This phase II, open-label, multicenter study enrolled pts with ED-SCLC sensitive to 1st-line platinum-based chemotherapy (recurrence or progression ≥90 days from 1st-line treatment). Pts aged ≥18 years with ECOG performance status (PS) ≤2 and only 1 prior therapy were eligible. Pts were randomized (2:1) to receive IV AMR 40 mg/m2/d (d, 1-3) or IV topotecan 1.5 mg/m2/d (d 1-5) and treated every 21 days until progression, unacceptable toxicity, or withdrawal. The primary endpoint, overall response rate (ORR, complete + partial response), used RECIST criteria. Secondary endpoints were progression-free survival (PFS), overall survival (OS), and safety. RESULTS In all, 76 pts were randomized to AMR (n=50) or topotecan (n=26) with AMR given for a median of 6 cycles (range 1-16) and topotecan 3 cycles (1-16). AMR significantly improved ORR rates vs topotecan (p<0.012; Table ). Median PFS/OS was 4.3 months (95% CI 2.0, 6.1)/9.3 months (95% CI 5.7, 12.0) with AMR vs 3.5 months (95% CI 2.1, 6.3)/8.9 months (95% CI 4.8, 13.8) with topotecan. There was a higher proportion of ECOG PS 2 pts in the AMR group (n=6) vs the topotecan group (n=2). A trend towards improved OS was observed in the ECOG 0-1 subgroup of 68 pts: median OS was 10.5 months with AMR vs 9.7 months with topotecan. The most common grade ≥3 adverse events with AMR vs topotecan were neutropenia (53% vs 74%), thrombocytopenia (31% vs 52%) and leukopenia (27% vs 30%). Three AMR pts (6%) and 1 topotecan pt (4%) died of neutropenic infection. CONCLUSIONS AMR significantly improves ORR and has acceptable tolerability as 2nd-line treatment in pts with sensitive ED-SCLC. [Table: see text] [Table: see text].
Medical and Psychological Risk Factors for Incident Hypertension in Type 1 Diabetic African-Americans

Objective. To determine risk factors for the development of hypertension among African-Americans living with type 1 diabetes. Methods. African-Americans with type 1 diabetes (n = 483) participated in a 6-year followup. At both baseline and followup blood pressure was measured twice in both sitting and standing positions using a standard protocol. Patients had a structured clinical interview, ocular examination, retinal photographs, and blood and urine assays and completed the Hostility and Direction of Hostility Questionnaire (HDHQ) and the Beck Depression Inventory (BDI). Results. Of the 280 diabetic patients with no hypertension at baseline, 82 (29.3%) subsequently developed hypertension over the 6-year followup. Baseline older age, longer duration of diabetes, family history of hypertension, greater mean arterial blood pressure, overt proteinuria, increasing retinopathy severity, peripheral neuropathy, smoking, and higher hostility scores were significantly associated with the development of hypertension. Multivariate analyses showed that higher hostility scores and overt proteinuria were significantly and independently associated with the development of hypertension in this population. Conclusions. The development of hypertension in African-Americans living with type 1 diabetes appears to be multifactorial and includes both medical (overt proteinuria) as well as psychological (high hostility) risk factors.
GATECloud.net: a platform for large-scale, open-source text processing on the cloud

Cloud computing is increasingly being regarded as a key enabler of the ‘democratization of science’, because on-demand, highly scalable cloud computing facilities enable researchers anywhere to carry out data-intensive experiments. In the context of natural language processing (NLP), algorithms tend to be complex, which makes their parallelization and deployment on cloud platforms a non-trivial task. This study presents a new, unique, cloud-based platform for large-scale NLP research—GATECloud. net. It enables researchers to carry out data-intensive NLP experiments by harnessing the vast, on-demand compute power of the Amazon cloud. Important infrastructural issues are dealt with by the platform, completely transparently for the researcher: load balancing, efficient data upload and storage, deployment on the virtual machines, security and fault tolerance. We also include a cost–benefit analysis and usage evaluation.
The Motivation for Intergenerational Time and Financial Transfers

This study investigated the motivation for intergenerational financial and time transfers between parents and adult children using data from the Health and Retirement Study. The results showed that emotional closeness between parents and adult children was significantly associated with both adult children to parent and parent to adult children transfers. In addition, parents and adult children who met frequently were more likely to help each other by making financial or time transfers. Also, financial transfers between parents and adult children were motivated by the donor’s altruism to the disadvantaged adult children or parents. However, wealthier parents and adult children with full-time jobs were less likely to make time transfers. The results of this study help in understanding the motivation for various types of intergenerational transfers in an aging society.
DISCOVERY OF A GALAXY CLUSTER WITH A VIOLENTLY STARBURSTING CORE AT z = 2.506

We report the discovery of a remarkable concentration of massive galaxies with extended X-ray emission at zspec = 2.506, which contains 11 massive (M* ≳ 1011 M⊙) galaxies in the central 80 kpc region (11.6σ overdensity). We have spectroscopically confirmed 17 member galaxies with 11 from CO and the remaining ones from Hα. The X-ray luminosity, stellar mass content, and velocity dispersion all point to a collapsed, cluster-sized dark matter halo with mass M200c = 1013.9±0.2 M⊙, making it the most distant X-ray-detected cluster known to date. Unlike other clusters discovered so far, this structure is dominated by star-forming galaxies (SFGs) in the core with only 2 out of the 11 massive galaxies classified as quiescent. The star formation rate (SFR) in the 80 kpc core reaches ∼3400 M⊙ yr−1 with a gas depletion time of ∼200 Myr, suggesting that we caught this cluster in rapid build-up of a dense core. The high SFR is driven by both a high abundance of SFGs and a higher starburst fraction (∼25%, compared to 3%–5% in the field). The presence of both a collapsed, cluster-sized halo and a predominant population of massive SFGs suggests that this structure could represent an important transition phase between protoclusters and mature clusters. It provides evidence that the main phase of massive galaxy passivization will take place after galaxies accrete onto the cluster, providing new insights into massive cluster formation at early epochs. The large integrated stellar mass at such high redshift challenges our understanding of massive cluster formation.
The Interaction Between Photoperiod and Nutrition and Its Effects on Seasonal Rhythms of Reproduction in the Ewe1

ABSTRACT In sheep, the seasonal patterns of reproductive activity are driven primarily by the annual photoperiodic cycle, but can also respond to other environmental factors, such as nutrition, yet little is known about the mechanisms underlying this interaction. This study was designed to define the interaction between photoperiodic and nutritional cues on seasonal patterns of ovarian activity, and to determine if there is a central interaction between these cues. Groups of Ile-de-France ewes were maintained in two nutritional states (restricted and well fed) under a simulated annual photoperiod of 8–16 h of light per day over two breeding seasons. At the end of the first breeding season, half of the animals of each group were ovariectomized (OVX) and fitted subcutaneously with estradiol implants. Low nutritional status shortened the season of ovarian activity, determined from the pattern of progesterone concentrations, by modifying the timing of seasonal transitions between periods of ovarian activity and anestrus. The same results were observed for the seasonal rhythm of neuroendocrine activity, assessed in the OVX ewes, from the pattern of luteinizing hormone concentrations. These results were then confirmed for neuroendocrine activity induced by a photoperiodic treatment. We conclude that nutrition centrally modulates the interpretation of photoperiod to affect seasonal reproductive transitions. The mechanisms of this interaction are discussed in the paper.
L'influence des facteurs sémantiques sur la cécité aux changements progressifs dans les scènes visuelles

Several studies have shown that under some circumstances observers have difficulty detecting changes that occur in successive views of a visual scene. Recent work has confirmed this finding in situations in which the change, instead of occurring abruptly, is made gradually but in full view. This work suggests that observers have access only to a small portion of the information available in a scene. The question arises, what determines which information will be accessed ? The experiments reported here first confirm that change blindness can be obtained using progressive changes in full view. Second, they investigate the influence on change detection of two semantic factors : « interest » of scene elements and their « consistency » within the scene. We show that change detection improves as a function of the « interest » of an element and as a function of its degree of« inconsistency » within the scene. The general discussion provides possible explanations of these results and their implications to the study of the nature of our representations.
Prosocial Foundations of Children's Academic Achievement

The present longitudinal research demonstrates robust contributions of early prosocial behavior to children's developmental trajectories in academic and social domains. Both prosocial and aggressive behaviors in early childhood were tested as predictors of academic achievement and peer relations in adolescence 5 years later. Prosocialness included cooperating, helping, sharing, and consoling, and the measure of antisocial aspects included proneness to verbal and physical aggression. Prosocialness had a strong positive impact on later academic achievement and social preferences, but early aggression had no significant effect on either outcome. The conceptual model accounted for 35% of variance in later academic achievement, and 37% of variance in social preferences. Additional analysis revealed that early academic achievement did not contribute to later academic achievement after controlling for effects of early prosocialness. Possible mediating processes by which prosocialness may affect academic achievement and other socially desirable developmental outcomes are proposed.
Voluntary Debt Exchanges in Sovereign Debt Markets ∗

We show that in some recent sovereign debt restructurings the sovereign both reduced its debt burden and made all of its payments while the market value of debt claims rose for the holders of the restructured debt. In these observations, both the government and its creditors could mutually benefit from such restructurings; hence, we refer to these episodes as ”voluntary” debt exchanges. We present a quantitative model in which these voluntary debt exchanges can occur because the debt level takes values above that which maximizes the market value of debt claims. In contrast to most previous studies on debt overhang, in our model opportunities for voluntary exchanges arise because a debt reduction implies a decline of the sovereign default risk. This is observed in the absence of any effect of debt reductions on future output levels. Although voluntary exchanges are Pareto improving at the time of the restructuring, we show that eliminating the possibility of conducting a voluntary exchange may improve welfare from an ex-ante perspective. Our results highlight a cost of initiatives that facilitate debt restructurings. JEL classification: F34, F41.
Optical parameters relevant for High Angular Resolution at Paranal from GSM instrument and surface layer contribution

Main atmospheric parameters characterizing the turbulence were measured at the Paranal ESO Observatory (Chile) with the Generalized Seeing Monitor (GSM) during 19 nights in November{December 1998. The median seeing for this period was 0:88 00 , a little worse than average, the spatial coherence outer scale of the wavefrontL0 =2 2:0 m and the median isoplanatic angle 0 =1 :90 00 . A very good agreement with seeing values given by ESO DIMM was found. Eects of ground layer turbulence were estimated from measurements of temperature micro{fluctuations at several altitudes. These measurements revealed that the rst 21 m above ground account for 12.5% of the total turbulent energy. Comparison between GSM and ESO DIMM values have permitted to highlight a local phenomenon which occurs sometimes at the site in the middle of the night. Statistics of the refractive index structure constant C 2 n in the surface layer is also studied.
Promoting Later Planned Retirement: The Differential Impact of Construal Level Interventions for Younger and Older Individuals

Individuals’ planned retirement age is affected by a trade-off between financial costs (a feasibility oriented consideration) and the number of years in retirement (a desirability oriented consideration). Previous research shows that construal level interventions (i.e., activating a global vs. local mindset with individuals) affect the relative importance of these two types of decision aspects such that primary considerations become more important under a global mindset compared to secondary considerations. In this research we predict that this results in an age-related reversal of the effect of a construal level induced global mindset on planned retirement age. The reason is that as individuals’ chronic temporal distance to retirement decreases (i.e., they become older) their primary retirement goals are likely to change. Younger individuals are temporally distant from retirement and primarily driven by desirability goals, while older individuals are temporally close to retirement and driven by feasibility goals. Therefore, since a global construal level intervention increases the impact of individuals’ primary goals, we predict that such an intervention decreases planned retirement age for the younger age group but increases it for the older age group. Results from two online surveys confirm this predicted decision process. They show first that indeed younger individuals are more likely than older individuals to plan for a retirement age that they cannot afford. Second, the results demonstrate that a construal level intervention-induced global mindset increases the impact of desirability considerations on planned retirement age for younger individuals (and lowers planned retirement age), but that it increases the impact of feasibility considerations for older individuals (and increases planned retirement age). Jointly, these findings underline the importance of taking into account both individuals’ chronic and situationally-induced mental construals of the planned retirement decision when designing policy communications to promote individuals’ retirement at a later age.
Applying social sciences to inspire behavioural change in the construction sector: an experimental study

In several reports, the construction industry has been criticized for inefficiencies, errors and increasing costs. Although the industry’s critics and researchers implicitly call for a change in human behaviour, this is seldom explicitly problematized by any of them. It is rather seen as a natural consequence of the suggested measures for improvements. Researchers have begun to question if the influence of human psychology has not been underestimated in the present approach. After a review of different psychological theories an action research investigation of how psychological factors might contribute to the recurring problems in the construction sector and to the difficulties of changing it is carried out. An intervention method has been developed to counteract the tendency of various psychological functions that can distort information. It was found that the problems professionals are experiencing dramatically differ from those expressed in some critical reports. During the process, the professionals discovered their own role in the problem scenario. This shows a way to pay more attention to human/psychological issues in action design within the construction context, and what can happen when this is done.
The Role of Cognitive Ability Tests in Employment Selection

Cognitive ability tests correlate with measures of job performance across many jobs. However, cognitive ability tests produce racial differences that are 3 to 5 times larger than other predictors-such as biodata, personality inventories, and the structured interview-that are valid predictors of job performance. Given that (a) cognitive ability tests can be combined with other predictors such that adverse impact is reduced while overall validity is increased, and (b) alternative predictors with less adverse impact can produce validity coefficients comparable to those obtained with cognitive ability tests alone, sole reliance on cognitive ability tests when alternatives are available is unwarranted.
YOUTH GANGS IN A SMALL MIDWESTERN CITY: INSIDERS’ PERSPECTIVES

ABSTRACT Youth gangs are not unique to large urban areas, but are now reported in a significant number of communities with lesser populations. In response to this reported phenomenon, gang researchers have begun to focus their attention on the structural conditions and processes that have given rise to these deviant groups in smaller-sized cities and towns. From recent studies of gangs in nonmetropolitan areas, we are now beginning to discern the true dimensions of youth gang involvement in communities with populations of 100,000 or less. We are also beginning to see that there may be some qualitative differences in the way gangs are structured based upon city size. After first reviewing the scholarly literature on the youth gang phenomenon in smaller community settings, this paper describes research on members of adolescent youth gangs in Kenosha, Wisconsin. Using the case of Kenosha, this study also questions the common assumption that proximity to a large urban area such as Chicago, with over 12,000 ga.