Miracle-dz/UniFAR-FTUs huggingface dataset:
Rifaximin and Propranolol Combination Therapy Is More Effective than Propranolol Monotherapy for the Reduction of Portal Pressure: An Open Randomized Controlled Pilot Study

Background/Aims Non-selective beta blockers (NSBBs) are currently the only accepted regimen for preventing portal hypertension (PHT)-related complications. However, the effect of NSBBs is insufficient in many cases. Bacterial translocation (BT) is one of the aggravating factors of PHT in cirrhosis; therefore, selective intestinal decontamination by rifaximin is a possible therapeutic option for improving PHT. We investigated whether the addition of rifaximin to propranolol therapy can improve hepatic venous pressure gradient (HVPG) response. Methods Sixty-four cirrhosis patients were randomly assigned to propranolol monotherapy (n=48) versus rifaximin and propranolol combination therapy (n=16). Baseline and post-treatment HVPG values, BT-related markers (lipopolysaccharide [LPS], LPS-binding protein [LBP], interleukin-6 [IL-6], and tumor necrosis factor α [TNF-α]), serological data, and adverse event data were collected. HVPG response rate was the primary endpoint. Results Combination therapy was associated with better HVPG response rates than monotherapy (56.2% vs 87.5%, p=0.034). In combination therapy, posttreatment BT-related markers were significantly decreased (LPS, p=0.005; LBP, p=0.005; IL-6, p=0.005; TNF-α, p=0.047). Conclusions Rifaximin combination therapy showed an additive effect in improving PHT compared to propranolol monotherapy. These pilot data suggest that the addition of rifaximin to NSBBs could be a good therapeutic option for overcoming the limited effectiveness of NSBBs.
Concerted evolution of the tandemly repeated genes encoding human U2 snRNA (the RNU2 locus) involves rapid intrachromosomal homogenization and rare interchromosomal gene conversion

We have surveyed the tandemly repeated genes encoding U2 snRNA in a diverse panel of humans. We found only two polymorphisms within the U2 repeat unit: a SacI polymorphism (alleles SacI+ or SacI−) and a CT microsatellite polymorphism (alleles CT+ or CT−). Surprisingly, individual U2 tandem arrays are entirely SacI+ or SacI−, and entirely CT+ or CT−, although the SacI and CT alleles can occur in any combination. We also found that polymorphisms in the left and right junction regions flanking the tandem array fall into only two haplotypes (JL+ and JL−, JR+ and JR−). Most surprisingly, JL+ is always associated with JR+, and JL− with JR−. Thus individual U2 arrays do not exchange flanking markers, despite independent assortment and subsequent homogenization of the SacI and CT alleles within the U2 repeat units. We propose that the primary driving force for concerted evolution of the tandem U2 genes is intrachromosomal homogenization; interchromosomal genetic exchanges are much rarer, and reciprocal nonsister chromatid exchange apparently does not occur. Thus concerted evolution of the U2 tandem array occurs in situ along a chromosome lineage, and linkage disequilibrium between sequences flanking the U2 array may persist for long periods of time.
Computing Popov Form of General Ore Polynomial Matrices

The computation of the Popov form of Ore polynomial matrices is formulated as a problem of computing the left nullspace of such matrices. While this technique is already known for polynomial matrices, the extension to Ore polynomial matrices is not immediate because multiplication of the matrix entries is not commutative. A number of results for polynomial matrices are extended to Ore polynomial matrices in this paper. This in turn allows nullspace algorithms to be used in Popov form computations. Fraction-free and modular algorithms for nullspace computation can be used in exact arithmetic setting where coefficient growth is a concern. When specialized to ordinary polynomial matrices, our results simplify the proofs for the computation of Popov form while keeping the same worst case complexity.
Size Polymorphisms of the Androgen Receptor Among Female Hispanics and Correlation With Androgenic Characteristics

Objective: To determine whether trinucleotide repeat polymorphisms of the androgen receptor gene correlate with androgenic measures in female Hispanics. Methods: We studied 110 human volunteers from an endocrine and infertility clinic. Measures of androgenism including Ferriman Gallwey scores, waist‐hip ratios, and body mass index (BMI) were correlated with the number of trinucleotide repeats of base sequence cytosine, adenine, and guanine in the androgen receptor gene. Serum testosterone was measured. Genomic DNA was obtained from leukocytes; amplification of the repeat region of the androgen receptor gene was performed and the products sized on an acrylamide gel. Results: Trinucleotide repeats within our population ranged from 12‐27, with a normal distribution. The number of repeats did not correlate with Ferriman Gallwey score or BMI, but correlated positively with waist‐hip ratios (n = 54; r = 0.39, P = .028). Normoandrogenic patients with idiopathic hirsutism showed an inverse relation between Ferriman Gallwey score and repeat size (n = 16; r = −0.60, P = .014). Conclusion: Our findings suggest that androgenism may be mildly influenced by the molecular characteristics of the androgen receptor. (Obstet Gynecol 1994;83:701‐6)
Biochemical impact of soccer: an analysis of hormonal, muscle damage, and redox markers during the season.

This study aimed to analyze changes in performance, muscle function, and stress-related biochemical markers in professional soccer players (n = 14) at 4 timepoints (3 for performance and 4 for stress-related biochemical markers) during the soccer season [Formula: see text] preseason (E1), midseason (E2), end of the season (E3) [Formula: see text] and after the end of the recovery period (E4). Performance in 5- and 30-m sprints, countermovement jump, and agility, and maximal isokinetic knee extension and knee flexion strength were measured (E1 to E3). We observed increased in-season levels of myoglobin (E2 > E1 and E4; p < 0.05), a higher testosterone/cortisol ratio (T/C), and increased levels of creatine kinase (CK), C-reactive protein, superoxide dismutase (SOD), protein sulfhydryls (-SH), and malondialdehyde (E2 and E3 > E1 and E4; p < 0.05). Lower cortisol concentrations (E3 < E1 and E4; p < 0.05) and glutathione reductase activity (E3 < E2 and E4; p < 0.05) were observed at the end of the season. T/C, CK, SOD, -SH, and malondialdehyde decreased during the off-season, and cortisol and glutathione reductase increased (E3 < E4; p < 0.05). Agility increased in E2 and E3 (p < 0.01). Significant correlations were found during the season between hormonal and muscle function parameters (r = 0.56-0.86; p < 0.05). In addition, in E2, significant associations were observed between match-accumulated time (MATE2; minutes played by each player during the competition period), performance, and hormonal and redox parameters (r = 0.456-0.615; p < 0.05). In conclusion, this study shows that soccer players face significant changes in biomarkers of physiologic strain (muscle damage and oxidative stress-related markers) during the season, but values return to normal during the off-season. Additionally, MAT influences physical, hormonal, and oxidative stress-related parameters in professional soccer players.
Antithrombotic therapy for long-term secondary prevention of acute coronary syndrome in high-risk patients

Patients with acute coronary syndrome (ACS) represent a major clinical burden, because they tend to experience recurrent ischemic events. Acute management of patients with ACS includes combination antithrombotic therapy composed of a parenteral anticoagulant and dual-antiplatelet therapy. Dual-antiplatelet therapy is also recommended for long-term secondary prevention of ACS. Despite advances in the antithrombotic therapies available, clinical trials suggest that patients with ACS still faceã10% risk of another event within 12–15 months of the index event. Certain patient populations, such as elderly patients and those with renal impairment or heart failure, are at higher risk of recurrent ACS events, because these patients have more vascular ischemic and bleeding risk factors than most other patients. Evidence from the GRACE and CRUSADE registries suggests underuse of the guideline-recommended evidence-based therapies for the management of ACS in such patients. This review summarizes the current standard of care for patients with ACS, focusing on long-term secondary antithrombotic strategies. Registry data are used to identify high-risk patient populations; the recent antiplatelet and anticoagulant Phase III trial data are summarized to highlight any patient populations who receive greater or lesser benefit from specific long-term antithrombotic strategies. Guideline recommendations are discussed and suggestions are provided to help improve implementation of long-term secondary prevention strategies and patient prognosis after an ACS event.
Ethnic differences in symptoms of insomnia among adolescents.

SUBJECT OBJECTIVE To provide data on the prevalence of symptoms of disturbed sleep, particularly insomnia, and to ascertain whether there are differentials attributable to ethnic culture or ethnic status. DESIGN Data were collected from youths (aged 11-17 years) and adult caregivers from a community-based sample of households using personal interviews and questionnaires. SETTING Managed-care subscriber populations in metropolitan area of over 4.5 million. PARTICIPANTS The sample consisted of 4175 youths and their caregivers (35.4% European American, 35.4% African American, 20.5% Mexican American, and 8.7% Other American). INTERVENTIONS N/A. MEASUREMENTS AND RESULTS The overall prevalence of DSM-IV insomnia-like syndrome in the past month was 4.7%. Females were more likely to report this syndrome, as were lower-income youths. Prevalence for European American youths was 5.3%, 5.2% for African American, and 3.5% Mexican American youths (p > .05). There also were some ethnic differences across symptoms of sleep disturbance that constitute insomnia. CONCLUSION For most comparisons, subsequent multivariate analyses indicate no significant ethnic difference, supporting the hypothesis that observed ethnic differences are due primarily to the effects of status differences (e.g., age, gender, socioeconomic status, etc.). Insomnia clearly is a major public health problem, with prevalences comparable to mood, anxiety and disruptive behavior disorders among adolescents.
Beta-Defensin 126 on the Surface of Macaque Sperm Mediates Attachment of Sperm to Oviductal Epithelia1

Abstract Beta-defensin 126 (DEFB126) coats the entire surface of macaque sperm until sperm become capacitated, and the removal of DEFB126 from over the head of sperm is required for sperm-zona recognition. Viable sperm collected from cervix and the uterine lumen of mated female macaques had DEFB126 coating the entire surface, suggesting that DEFB126 is retained on sperm en route to the oviduct. DEFB126 plays a major role in attachment of sperm to oviductal epithelial cells (OECs). Following treatment to either remove or alter DEFB126, sperm were coincubated with explants of OECs, which were assessed for sperm binding following rinsing to remove superficially attached sperm. Sperm treated with either 1 mM caffeine + 1 mM dibutyryl cyclic adenosine monophosphate (dbcAMP) (induces capacitation and complete release of DEFB126 from sperm), 2 mM caffeine (removes DEFB126 from over the head and midpiece but does not induce capacitation), anti-DEFB126 immunoglobulin, or neuraminidase (cleaves sialic acid from terminal positions on glycosylation sites of DEFB126) resulted in similar and significant levels of inhibition of sperm-OEC binding. Preincubation of OECs with soluble DEFB126 also resulted in significantly reduced sperm-OEC binding. Furthermore, reduced OEC binding capability of sperm lacking DEFB126 could be restored by addition of soluble DEFB126 to the sperm surface prior to incubation with OECs. Finally, purified DEFB126, infused into oviducts in situ, associated primarily with the apical membranes of secretory-type epithelial cells. In summary, treatments of macaque sperm that result in either removal, masking, or alteration of DEFB126 result in loss of sperm-OEC binding that is independent of changes in sperm motility. DEFB126 may be directly involved in the formation of a reservoir of sperm in the oviduct of macaques.
Cloud‐Resolving Model Intercomparison of an MC3E Squall Line Case: Part II. Stratiform Precipitation Properties

In this second part of a cloud microphysics scheme intercomparison study, we focus on biases and variabilities of stratiform precipitation properties for a midlatitude squall line event simulated with a cloud‐resolving model implemented with eight cloud microphysics schemes. Most of the microphysics schemes underestimate total stratiform precipitation, mainly due to underestimation of stratiform precipitation area. All schemes underestimate the frequency of moderate stratiform rain rates (2–6 mm/hr), which may result from low‐biased ice number and mass concentrations for 0.2–2‐mm diameter particles in the stratiform ice region. Most simulations overestimate ice water content (IWC) at altitudes above 7 km for temperatures colder than −20 °C but produce a decrease of IWC approaching the melting level, which is opposite to the trend shown by in situ observations. This leads to general underestimations of stratiform IWC below 5‐km altitude and rainwater content above 1‐km altitude for a given rain rate. Stratiform precipitation area positively correlates with the convective condensate detrainment flux but is modulated by hydrometeor type, size, and fall speed. Stratiform precipitation area also changes by up to 17%–25% through alterations of the lateral boundary condition forcing frequency. Stratiform precipitation, rain rate, and area across the simulations vary by a factor of 1.5. This large variability is primarily a result of variability in the stratiform downward ice mass flux, which is highly correlated with convective condensate horizontal detrainment strength. The variability of simulated local microphysical processes in the stratiform region plays a secondary role in explaining variability in simulated stratiform rainfall properties.
System level evaluation of cooperative MIMO-OFDMA-based heterogeneous networks

Coordinated multipoint transmission (CoMP) is considered for a heterogeneous network where different kinds of base stations (BSs) are located. We present a system level simulator for investigating the gains that can be achieved from the use of cooperative transmission (CoMP) in an urban heterogeneous cellular environment. It is shown that the spectral efficiency of the users located within a macro-cellular environment may significantly increase by employing low-power nodes (femtocells). On the other hand, the spectral efficiency of cell-edge users is decreased due to the additional inter-cell interference introduced by the use of such femtocells. Furthermore, it is shown that significant gain can be achieved by the cooperation of the BSs. From a users point of view, the inter-cell interference is reduced, and thus, the spectral efficiency per user can be significantly enhanced.
Formation of the Permian Taipinggou igneous rocks, north of Luobei (Northeast China): implications for the subduction of the Mudanjiang Ocean beneath the Bureya–Jiamusi Massif

ABSTRACT Controversy has long surrounded the tectonic framework and evolution of the Mudanjiang Ocean between the Bureya–Jiamusi–Khanka Massif and Songnen–Zhangguangcai Range Massif, which are located in the easternmost segment of the Central Asian Orogenic Belt. To address these issues, we present zircon U-Pb ages, geochemical data, and zircon Hf isotopic compositions of the Taipinggou amphibolite and metagabbro exposed along the boundary area of Bureya–Jiamusi Massif and Songnen–Zhangguangcai Range Massif. Magmatic zircons from the amphibolite and metagabbro yield 206Pb/238U ages of 267 ± 2 Ma and 264 ± 2 Ma, respectively, which are interpreted as protolith ages. The geochemical data of the amphibolite samples show transitional characteristics of calcalkaline to tholeiitic series, with high MgO concentrations (9.44–10.48 wt.%) and Mg-numbers (73–75). These samples are enriched in large ion lithophile elements (e.g. Rb, Ba, and K) and light rare earth elements and are depleted in high-field-strength elements (e.g. Nb, Ta, and Ti) and heavy rare earth elements, with εHf(t) values of −6.63 to −3.26. It is inferred that the parental magma originated from an enriched lithospheric mantle that had been metasomatized by fluids derived from subducted oceanic slab. During magma evolution, the magma that formed the amphibolite mainly experienced accumulation with a shallow-level evolutionary process involving fractional crystallization. The Taipinggou metagabbro samples are subalkaline series and also characterized by enrichment in large ion lithophile elements (e.g. Rb, Ba, and K) and light rare earth elements and by depletion in Nb–Ta–P–Ti, with εHf(t) values of −3.09 to +1.16. The Taipinggou metagabbro and amphibolite have similar geochemical and Hf isotopic compositions, indicating a common parental magma source but with different degrees of magmatic differentiation. Based on the new geochronological and geochemical data presented in this study, we propose that both the Taipinggou metagabbro and amphibolite formed in a Middle Permian continental arc setting, closely related to eastward subduction beneath the Bureya–Jiamusi Massif. Combined with previous studies and regional geological observations, we suggest that a double-side subduction model is favoured for the Late Palaeozoic–Early Mesozoic geodynamic processes along the boundary area of Bureya–Jiamusi–Khanka Massif and Songnen–Zhangguangcai Range Massif. GRAPHICAL ABSTRACT
Space-Constrained Massive MIMO: Hitting the Wall of Favorable Propagation

The recent development of the massive multiple-input multiple-output (MIMO) paradigm, has been extensively based on the pursuit of favorable propagation: in the asymptotic limit, the channel vectors become nearly orthogonal and inter-user interference tends to zero [1]. In this context, previous studies have considered fixed inter-antenna distance, which implies an increasing array aperture as the number of elements increases. Here, we focus on a practical, space-constrained topology, where an increase in the number of antenna elements in a fixed total space imposes an inversely proportional decrease in the inter-antenna distance. Our analysis shows that, contrary to existing studies, inter-user interference does not vanish in the massive MIMO regime, thereby creating a saturation effect on the achievable rate.
Internet Search Patterns of Human Immunodeficiency Virus and the Digital Divide in the Russian Federation: Infoveillance Study

Background Human immunodeficiency virus (HIV) is a serious health problem in the Russian Federation. However, the true scale of HIV in Russia has long been the subject of considerable debate. Using digital surveillance to monitor diseases has become increasingly popular in high income countries. But Internet users may not be representative of overall populations, and the characteristics of the Internet-using population cannot be directly ascertained from search pattern data. This exploratory infoveillance study examined if Internet search patterns can be used for disease surveillance in a large middle-income country with a dispersed population. Objective This study had two main objectives: (1) to validate Internet search patterns against national HIV prevalence data, and (2) to investigate the relationship between search patterns and the determinants of Internet access. Methods We first assessed whether online surveillance is a valid and reliable method for monitoring HIV in the Russian Federation. Yandex and Google both provided tools to study search patterns in the Russian Federation. We evaluated the relationship between both Yandex and Google aggregated search patterns and HIV prevalence in 2011 at national and regional tiers. Second, we analyzed the determinants of Internet access to determine the extent to which they explained regional variations in searches for the Russian terms for “HIV” and “AIDS”. We sought to extend understanding of the characteristics of Internet searching populations by data matching the determinants of Internet access (age, education, income, broadband access price, and urbanization ratios) and searches for the term “HIV” using principal component analysis (PCA). Results We found generally strong correlations between HIV prevalence and searches for the terms “HIV” and “AIDS”. National correlations for Yandex searches for “HIV” were very strongly correlated with HIV prevalence (Spearman rank-order coefficient [rs]=.881, P≤.001) and strongly correlated for “AIDS” (rs=.714, P≤.001). The strength of correlations varied across Russian regions. National correlations in Google for the term “HIV” (rs=.672, P=.004) and “AIDS” (rs=.584, P≤.001) were weaker than for Yandex. Second, we examined the relationship between the determinants of Internet access and search patterns for the term “HIV” across Russia using PCA. At the national level, we found Principal Component 1 loadings, including age (-0.56), HIV search (-0.533), and education (-0.479) contributed 32% of the variance. Principal Component 2 contributed 22% of national variance (income, -0.652 and broadband price, -0.460). Conclusions This study contributes to the methodological literature on search patterns in public health. Based on our preliminary research, we suggest that PCA may be used to evaluate the relationship between the determinants of Internet access and searches for health problems beyond high-income countries. We believe it is in middle-income countries that search methods can make the greatest contribution to public health.
The taphonomy of birds

The taphonomy of birds can be investigated with actualistic studies complem~nted by reviewing Konversat Lagerstatten such as Messel, Green River and Solnhofen. Two field sites were chosen in southern Florida: 1, a freshwater (16-23 ppt salinity) environment in which biogenic carbonate muds were being deposited and 2, a . marine (30-34 ppt salinity) environment in which pyritous carbonate muds were being deposited. Ninety-six specimens (36 genera, 40 species) were used in this study (these were obtained from a wildlife centre where they died of natural causes). Experiments were set up in both marine and freshwater sites in the following categories: large protected, unprotected; small protected, unprotected. Protected specimens were placed in metal cages coated with small mesh (I.5mm 2) nylon netting. The specimens were allowed to degrade under natural conditions. The following variables were recorded daily over a seventy day period: air and water temperature, humidity, rainfall, wind and current speed and direction, salinity, dissolved oxygen content, pH, and water depth. Specimens from each of the eight categories were sampled at day 1,4,7, 11,28,56, and 70.
Differential contributions of central and effector memory T cells to recall responses

Although the absolute number of memory CD8+ T cells established in the spleen following antigen encounter remains stable for many years, the relative capacity of these cells to mediate recall responses is not known. Here we used a dual adoptive transfer approach to demonstrate a progressive increase in the quality of memory T cell pools in terms of their ability to proliferate and accumulate at effector sites in response to secondary pathogen challenge. This temporal increase in efficacy occurred in CD62Llo (effector memory) and CD62Lhi (central memory) subpopulations, but was most prominent in the CD62Lhi subpopulation. These data indicate that the contribution of effector memory and central memory T cells to the recall response changes substantially over time.