Miracle-dz/UniFAR-FTUs huggingface dataset:
A Meta-Analysis of Utility Estimates for HIV/AIDS

The authors performed a meta-analysis to derive pooled utilities for HIV/AIDS and to assess the relative importance of study design characteristics in predicting utilities. Twenty-five articles were identified reporting 74 unique utilities elicited from 1956 respondents. The authors used a hierarchical linear model to perform the meta-analysis, with disease stage, elicitation method, respondent type, and the upper-bound and lower-bound labels for the utility scale as the independent variables. Disease stage (P = 0.016) and respondent type (P = 0.014) were significant predictors of utility. Elicitation method was of marginal significance (P = 0.052). Bounds were not significant. Pooling utilities, the authors estimate a utility of 0.70 for AIDS, 0.82 for symptomatic HIV, and 0.94 for asymptomatic HIV when the time tradeoff method is used to elicit utilities from patients and the scale ranges from death to perfect health. The pooled utilities reported here should be of great use to researchers performing cost-utility analyses of interventions for HIV/AIDS.
Heart valvular disease in patients with Parkinson’s disease treated with high-dose pergolide

The authors report the clinical, echocardiographic, and pathologic findings in two patients treated with more than 5 mg of pergolide daily who developed symptomatic severe heart failure due to restrictive valvular disease. They also describe the echocardiographic data of another eight patients taking similar doses of pergolide presenting no clinical signs of heart failure. The findings suggest a possible role of high doses of pergolide in inducing restrictive valvular disease.
Development and technical basis of simplified guidelines for emergency triage assessment and treatment in developing countries

Simplified guidelines for the emergency care of children have been developed to improve the triage and rapid initiation of appropriate emergency treatments for children presenting to hospitals in developing countries. The guidelines are part of the effort to improve referral level paediatric care within the World Health Organisation/Unicef strategy integrated management of childhood illness (IMCI), based on evidence of significant deficiencies in triage and emergency care. Existing emergency guidelines have been modified according to resource limitations and significant differences in the epidemiology of severe paediatric illness and preventable death in developing countries with raised infant and child mortality rates. In these settings, it is important to address the emergency management of diarrhoea with severe dehydration, severe malaria, severe malnutrition, and severe bacterial pneumonia, and to focus attention on sick infants younger than 2 months of age. The triage assessment relies on a few clinical signs, which can be readily taught so that it can be used by health workers with limited clinical background. The assessment has been designed so that it can be carried out quickly if negative, making it functional for triaging children in queues.
Circle Time: A Much‐neglected Resource in Secondary Schools?

Throughout this article, unless otherwise stated, the use of the term ‘circle time’ refers to a whole‐class meeting where everyone sits in a circle. It is a forum that is bound by strict groundrules to ensure emotional ‘safety’ and respectful listening. Different approaches to circle‐time are used at all levels of education. In this article ‘Circle Time’ (with initial capitals) refers to the Quality Circle Time Model and the strategies used within the circle as devised by Jenny Mosley (1989, 1993, 1996) as opposed to the many other circle‐time methods to be found in educational practice.
Codimension one Anosov flows and a conjecture of Verjovsky

Let $ \Phi $ be a $C^2$ codimension one Anosov flow on a compact Riemannian manifold $M$ of dimension greater than three. Verjovsky conjectured that $ \Phi $ admits a global cross-section and we affirm this conjecture when $ \Phi $ is volume preserving in the following two cases: (1) if the sum of the strong stable and strong unstable bundle of $\Phi$ is $ \theta $-Hölder continuous for all $ \theta < 1 $; (2) if the center stable bundle of $ \Phi $ is of class $ C^{1 + \theta} $ for all $ \theta < 1 $. We also show how certain transitive Anosov flows (those whose center stable bundle is $C^1$ and transversely orientable) can be ‘synchronized’, that is, reparametrized so that the strong unstable determinant of the time $t$ map (for all $t$) of the synchronized flow is identically equal to $ e^t $. Several applications of this method are given, including vanishing of the Godbillon–Vey class of the center stable foliation of a codimension one Anosov flow (when $ \dim M > 3 $ and that foliation is $ C^{1 + \theta} $ for all $ \theta < 1 $), and a positive answer to a higher-dimensional analog to Problem 10.4 posed by Hurder and Katok in [HK].
Spatial pattern of intra-laminar connectivity in supragranular mouse auditory cortex

Neuronal responses and topographic organization of feature selectivity in the cerebral cortex are shaped by ascending inputs and by intracortical connectivity. The mammalian primary auditory cortex has a tonotopic arrangement at large spatial scales (greater than 300 microns). This large-scale architecture breaks down in supragranular layers at smaller scales (around 300 microns), where nearby frequency and sound level tuning properties can be quite heterogeneous. Since layer 4 has a more homogeneous architecture, the heterogeneity in supragranular layers might be caused by heterogeneous ascending input or via heterogeneous intralaminar connections. Here we measure the functional 2-dimensional spatial connectivity pattern of the supragranular auditory cortex on micro-column scales. In general connection probability decreases with radial distance from each neuron, but the decrease is steeper in the isofrequency axis leading to an anisotropic distribution of connection probability with respect to the tonotopic axis. In addition to this radial decrease in connection probability we find a patchy organization of inhibitory and excitatory synaptic inputs that is also anisotropic with respect to the tonotopic axis. These periodicities are at spatial scales of ~100 and ~300 μm. While these spatial periodicities show anisotropy in auditory cortex, they are isotropic in visual cortex, indicating region specific differences in intralaminar connections. Together our results show that layer 2/3 neurons in auditory cortex show specific spatial intralaminar connectivity despite the overtly heterogeneous tuning properties.
Typicality in categorization, recognition and identification: Evidence from face recognition

The proponents of exemplar models of categorization and memory have claimed that recognition judgements are based on familiarity computed by summing the similarity between a probe and all exemplars in memory. A probe which is highly similar to many previously seen exemplars should be recognized more accurately or faster than a more dissimilar probe. The ‘summed-similarity rule’ has been supported in a number of experiments on recognition of relatively unfamiliar and artificial stimuli. However, evidence from face recognition clearly contradicts the rule. Distinctive or unusual faces are recognized more accurately than typical faces. It is proposed that this contradiction can be resolved if tasks using photographs of faces as stimuli which have been termed ‘recognition’ tasks are interpreted as ‘identification’ tasks. However, if this interpretation is made, an exemplar model is not the only class of models which can account for the effects of distinctiveness in face ‘classification’ and ‘identification’ tasks. Three simulations are reported which show that parallel distributed processing models can also account for the data from face-processing tasks. Two simulations are based on a single-layer auto-associative network. The final simulation is based on a multi-layer network using backward error propagation.
Batch effect removal methods for microarray gene expression data integration: a survey

Genomic data integration is a key goal to be achieved towards large-scale genomic data analysis. This process is very challenging due to the diverse sources of information resulting from genomics experiments. In this work, we review methods designed to combine genomic data recorded from microarray gene expression (MAGE) experiments. It has been acknowledged that the main source of variation between different MAGE datasets is due to the so-called 'batch effects'. The methods reviewed here perform data integration by removing (or more precisely attempting to remove) the unwanted variation associated with batch effects. They are presented in a unified framework together with a wide range of evaluation tools, which are mandatory in assessing the efficiency and the quality of the data integration process. We provide a systematic description of the MAGE data integration methodology together with some basic recommendation to help the users in choosing the appropriate tools to integrate MAGE data for large-scale analysis; and also how to evaluate them from different perspectives in order to quantify their efficiency. All genomic data used in this study for illustration purposes were retrieved from InSilicoDB http://insilico.ulb. ac.be.
The polyamine analogue N1,N11‐diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines

We have been investigating the effects of natural polyamines and polyamine analogues on the survival and apoptosis of chondrocytes, which are cells critical for cartilage integrity. Treatment of human C‐28/I2 chondrocytes with N1,N11‐diethylnorspermine (DENSPM), a polyamine analogue with clinical relevance as an experimental anticancer agent, rapidly induced spermidine/spermine N1‐acetyltransferase (SSAT) and spermine oxidase (SMO), key enzymes of polyamine catabolism and down‐regulated ornithine decarboxylase, the first enzyme of polyamine biosynthesis, thus depleting all main polyamines within 24 h. The treatment with DENSPM did not provoke cell death and caspase activation when given alone for 24 h, but caused a caspase‐3 and ‐9 dependent apoptosis in chondrocytes further exposed to cycloheximide (CHX). In other cellular models, enhanced polyamine catabolism or polyamine depletion has been implicated as mechanisms involved in DENSPM‐related apoptosis. However, the simultaneous addition of DENSPM and CHX rapidly increased caspase activity in C‐28/I2 cells in the absence of SSAT and SMO induction or significant reduction of polyamine levels. Moreover, caspase activation induced by DENSPM plus CHX was not prevented by a N1‐acetylpolyamine oxidase (PAO)/SMO inhibitor, and depletion of all polyamines obtained by specific inhibitors of polyamine biosynthesis did not reproduce DENSPM effects in the presence of CHX. DENSPM/CHX‐induced apoptosis was associated with changes in the amount or activation of signalling kinases, Akt and MAPKs, and increased uptake of DENSPM. In conclusion, the results suggest that DENSPM can favour apoptosis in chondrocytes independently of its effects on polyamine metabolism and levels. J. Cell. Physiol. 219: 109–116, 2009. © 2008 Wiley‐Liss, Inc.
Composition of volatile in micropropagated and field grown aromatic plants from Tuscany Islands.

Aromatic plant species present in the natural Park of Tuscany Archipelago are used as flavoring agents and spices, as dietary supplements and in cosmetics and aromatherapy. The plants are usually collected from wild stands, inducing a depletion of the natural habitat. Therefore, micropropagation of these aromatic plants can play a role in the protection of the natural ecosystem, can guarantee a massive sustainable production and can provide standardized plant materials for diverse economical purposes. The aim of this study is to compare the volatile organic compounds produced by the wild plants with those from in vitro plantlets using headspace solid phase micro-extraction (HS-SPME) followed by capillary gas-chromatography coupled to mass spectrometry (GC-MS). Typical plants of this natural area selected for this work were Calamintha nepeta L. , Crithmum maritimum L. , Lavandula angustifolia L. , Myrtus communis L. , Rosmarinus officinalis L. , Salvia officinalis L. and Satureja hortensis L. Different explants were used: microcuttings with vegetative apical parts, axillary buds and internodes. Sterilization percentage, multiplication rate and shoot length, as well as root formation were measured. The volatile aromatic profiles produced from in vitro plantlets were compared with those of the wild plants, in particular for C. maritimum, R. officinalis, S. officinalis and S. hortensis. This study indicated that the micropropagation technique can represent a valid alternative to produce massive and sterile plant material characterised by the same aromatic flavour as in the wild grown plants.
Implications of No Child Left Behind on Family Literacy in a Multicultural Community

prescriptions of life; they are the actions and reflections of life. Life cannot be controlled with prescribed established formulas. So, members of life will succeed only when they are able to collaboratively consider and use individuals’ ideas, skills, talents, and expertise to face life’s countless challenges. Similarly, this article, in response to the No Child Left Behind Act of 2001 (NCLB), is based in the belief that members of an educational community must collaboratively reflect and act on issues to develop a truly effective program.
Twin nucleation in Fe-based bcc alloys—modeling and experiments

We develop an analytical expression for twin nucleation stress in bcc metal and alloys considering generalized planar fault energy and the dislocations bounding the twin nucleus. We minimize the total energy to predict the twinning stress relying only on parameters that are obtained through atomistic calculations, thus excluding the need for any empirical constants. We validate the present approach by means of precise measurements of the onset of twinning in bcc Fe–50at% Cr single crystals showing excellent agreement. The experimental observations of the three activated slip systems of symmetric configuration in relation to the twinning mechanism are demonstrated via transmission electron microscopy techniques along with digital image correlation. We then confirm the validity of the model for Fe, Fe–25at% Ni and Fe–3at% V alloys compared with experiments from the literature to show general applicability.
System Architecture for Temporal Information Extraction, Representationand Reasoning in Clinical Narrative Reports

Exploring temporal information in narrative Electronic Medical Records (EMRs) is essential and challenging. We propose an architecture for an integrated approach to process temporal information in clinical narrative reports. The goal is to initiate and build a foundation that supports applications which assist healthcare practice and research by including the ability to determine the time of clinical events (e.g., past vs. present). Key components include: (1) an annotation schema for temporal expressions and the development of an associated tagger; (2) a natural language processing (NLP) system for encoding and extracting medical events and associating them with formalized temporal data; (3) a post-processor, with a knowledge-based subsystem to help discover implicit information, that resolves temporal expressions and deals with issues such as granularity and vagueness; and (4) a reasoning mechanism which models clinical reports as Simple Temporal Problems (STPs).
Promoter prediction in the human genome

Computational prediction of eukaryotic poIII promoters has been one of the most elusive problems despite considerable effort devoted to the study. Researchers have looked for various types of signals around the transcriptional start site (TSS), viz. oligo-nucleotide statistics, potential binding sites for core factors, clusters of binding sites, proximity to CpG islands etc. The proximity of CpG islands to gene starts is now a well established fact, although until recently, it was based on very little genomic data. In this work we explore the possibility of enhancing the promoter prediction accuracy by combining CpG island information with a few other, biologically motivated, seemingly independent signals, that cover most of the known knowledge. We benchmarked the method on a much larger genomic datasets compared to previous studies. We were able to improve slightly upon current prediction accuracy. Furthermore, we observe that CpG islands are the most dominant signals and the other signals do not improve the prediction. This suggests that the computational prediction of promoters for genes with no associated CpG-island (typically having tissue-specific expression) looking only at the immediate neighborhood of the TSS may not even be possible. We suggest some biological experiments and studies to better understand the biology of transcription.
Sounds of intent, phase 2: gauging the music development of children with complex needs

This article reports the latest phase of research in the Sounds of intent project, which is seeking, as a long‐term goal, to map musical development in children and young people with severe, or profound and multiple learning difficulties (SLD or PMLD). Previous exploratory work had resulted in a framework of six putative music‐developmental stages set across three domains of musical engagement: reactivity, proactivity and interactivity. This was intended as a first step in enabling teachers and therapists to gauge their pupils’ levels of musical development. The research described in this paper indicates that a moderately fine‐grained observation schedule (involving three sub‐levels per Sounds of intent developmental stage) may be sufficient to show longitudinal change in the observed musical engagement of pupils with PMLD, three groups of whom participated in a specially designed programme of musical activities over a six‐month period. However, mapping the individual’s levels of attainment onto their chronological ages indicates that, generally speaking, musical progress is likely to be made in tiny increments – notionally equivalent to around one Sounds of intent level during a child’s entire time in compulsory education (4–16 in the UK). This suggests that an even finer‐grained observation scheme may be of value to practitioners seeking to chart change in the longer term. It is proposed that this should be the subject of further research, and should comprise two components: level and frequency of engagement.
Characterization of Staphylococcus species isolated from raw milk and milk products (lben and jben) in North Morocco.

BACKGROUND To investigate the incidence and antibiotic resistance of staphylococcal strains isolated from milk and milk products and to trace the ecological origin of the Staphylococcus aureus isolated. METHODOLOGY Eighty-one samples of raw milk, lben (whey) and jben (cheese) were analyzed for the presence of staphylococcal strains. Isolates were identified by Gram stains, tests for coagulase, the API staph system and the WalkAway 40/96, which also determines the antimicrobial susceptibility profiles. The S. aureus strains were biotyped, and variable regions of the coagulase gene were amplified using the polymerase chain reaction. RESULTS The identification results showed a predominance of coagulase-negative staphylococci (54 %). Coagulase-positive staphylococci that were identified were divided into 3 groups comprising S. aureus (40%), Staphylococcus intermedius (2 %) and Staphylococcus hyicus (4%). Among the S. aureus that was isolated, biotype C was the predominant biotype. Among 40 coagulase gene PCR-amplification products, 37 produced a single band, while 3 isolates produced two bands. The antimicrobial susceptibility-profile of the staphylococcal strains revealed a high incidence of S. aureus to penicillin G. In addition, Staphylococcus lentus presented considerable resistance to the oxacillin, erythromycin and lincomycin. CONCLUSIONS The presence of staphylococci in raw milk, lben and jben in areas of northern Morocco poses a health hazard, so it is necessary for the public health inspectors to properly examine the conditions during production, storage and commercialization of all products made with unpasteurized milk.
Stable whole-body motion generation for humanoid robots to imitate human motions

This work presents a methodology to generate dynamically stable whole-body motions for a humanoid robot, which are converted from human motion capture data. The methodology consists of the kinematic and dynamical mappings for human-likeness and stability, respectively. The kinematic mapping includes the scaling of human foot and Zero Moment Point (ZMP) trajectories considering the geometric differences between a humanoid robot and a human. It also provides the conversion of human upper body motions using the method in [1]. The dynamic mapping modifies the humanoid pelvis motion to ensure the movement stability of humanoid whole-body motions, which are converted from the kinematic mapping. In addition, we propose a simplified human model to obtain a human ZMP trajectory, which is used as a reference ZMP trajectory for the humanoid robot to imitate during the kinematic mapping. A human whole-body dancing motion is converted by the methodology and performed by a humanoid robot with online balancing controllers.
Blepharospasm plus Cervical Dystonia with Predominant Anterocollis: A Distinctive Subphenotype of Segmental Craniocervical Dystonia

Background Dystonia of the eyelids often spreads to affect other muscles in the craniocervical region. Certain blepharospasm-plus subphenotypes may be clinically unique. Methods Seven subjects with the subphenotype of late-onset blepharospasm with apraxia of eyelid opening and cervical dystonia with predominant anterocollis were identified from a database of over 1800 patients with primary dystonia. Results Blepharospasm was the first affected site in 6/7 subjects, followed by spread of the disease to the cervical muscles. Although four patients also had other forms of dystonia (laryngeal, lower face), none showed spread outside the craniocervical region. A family history of dystonia was present in 4/7. No mutations were identified in THAP1 or TOR1A. Overall, blepharospasm was difficult to treat, typically requiring both myectomy and substantial doses of botulinum toxin into the pretarsal orbicularis oculi muscles. In one subject, anterocollis markedly improved after deep brain stimulation. Discussion Delineation and characterization of craniocervical dystonia subphenotypes may serve to guide genetic and therapeutic studies, in addition to clinical interventions. The blepharospasm with apraxia of eyelid opening and anterocollis subphenotype can be therapeutically challenging.