Miracle-dz/UniFAR-FTUs huggingface dataset:
Medical Care and Mortality: Racial Differences in Preventable Deaths

We analyzed deaths of blacks and whites in Alameda County, California where previous studies have documented consistent racial inequalities in health services. We classified each death during 1978 as due to preventable and manageable conditions or as “non-preventable” according to lists compiled by the Working Group on Preventable and Manageable Diseases chaired by Dr. David Rutstein. The total death rate for blacks 0–65 years of age exceeded that of whites by 58 percent (p < .01). Rates of death due to preventable and manageable conditions for persons aged 0–65 years were 77 percent higher for blacks than for whites (p < .01). More than one-third of the excess total death rate of blacks relative to whites could be explained by the excess of potentially preventable deaths. Our findings suggest that inequalities in health services reinforce broader social inequalities and are in part responsible for disparities in health status. Improvements in the health and longevity of blacks and other oppressed groups might be achieved by improved access to existing medical, public health, and other preventive measures.
The Th17–ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease

The ELR+ CXC chemokines CXCL1 and CXCL2 are up-regulated in the central nervous system (CNS) during multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). However, their functional significance and the pathways regulating their expression are largely unknown. We show that transfer of encephalitogenic CD4+ Th17 cells is sufficient to induce CXCL1 and CXCL2 transcription in the spinal cords of naive, syngeneic recipients. Blockade or genetic silencing of CXCR2, a major receptor for these chemokines in mice, abrogates blood–brain barrier (BBB) breakdown, CNS infiltration by leukocytes, and the development of clinical deficits during the presentation as well as relapses of EAE. Depletion of circulating polymorphonuclear leukocytes (PMN) had a similar therapeutic effect. Furthermore, injection of CXCR2+ PMN into CXCR2−/− mice was sufficient to restore susceptibility to EAE. Our findings reveal that a Th17–ELR+ CXC chemokine pathway is critical for granulocyte mobilization, BBB compromise, and the clinical manifestation of autoimmune demyelination in myelin peptide–sensitized mice, and suggest new therapeutic targets for diseases such as MS.
Partial Extensively Drug-Resistant Tuberculosis in an HIV-Infected Child

Tuberculosis (TB) is one of the most common opportunistic infections that affects patients with HIV. HIV and TB coinfection have a synergistic effect on each other, with one disease worsening the effects and treatment of the other. In the recent past, varying levels of drug resistance are also found in patients coinfected with HIV and TB, but rarely is it reported in children in India. The present case documents partial extensively drug-resistant TB in an 8-year-old child.
Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer

The interaction between tumor cells and their microenvironment is an essential aspect of tumor development. Therefore, understanding how this microenvironment communicates with tumor cells is crucial for the development of new anti-cancer therapies. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit gene expression. They are secreted into the extracellular medium in vesicles called exosomes, which allow communication between cells via the transfer of their cargo. Consequently, we hypothesized that circulating endothelial miRNAs could be transferred to tumor cells and modify their phenotype. Using exogenous miRNA, we demonstrated that endothelial cells can transfer miRNA to tumor cells via exosomes. Using miRNA profiling, we identified miR-503, which exhibited downregulated levels in exosomes released from endothelial cells cultured under tumoral conditions. The modulation of miR-503 in breast cancer cells altered their proliferative and invasive capacities. We then identified two targets of miR-503, CCND2 and CCND3. Moreover, we measured increased plasmatic miR-503 in breast cancer patients after neoadjuvant chemotherapy, which could be partly due to increased miRNA secretion by endothelial cells. Taken together, our data are the first to reveal the involvement of the endothelium in the modulation of tumor development via the secretion of circulating miR-503 in response to chemotherapy treatment.
T-SGX: Eradicating Controlled-Channel Attacks Against Enclave Programs

Intel Software Guard Extensions (SGX) is a hardware-based Trusted Execution Environment (TEE) that enables secure execution of a program in an isolated environment, called an enclave. SGX hardware protects the running enclave against malicious software, including the operating system, hypervisor, and even low-level firmware. This strong security property allows trustworthy execution of programs in hostile environments, such as a public cloud, without trusting anyone (e.g., a cloud provider) between the enclave and the SGX hardware. However, recent studies have demonstrated that enclave programs are vulnerable to accurate controlled-channel attacks conducted by a malicious OS. Since enclaves rely on the underlying OS, curious and potentially malicious OSs can observe a sequence of accessed addresses by intentionally triggering page faults. In this paper, we propose T-SGX, a complete mitigation solution to the controlled-channel attack in terms of compatibility, performance, and ease of use. T-SGX relies on a commodity component of the Intel processor (since Haswell), called Transactional Synchronization Extensions (TSX), which implements a restricted form of hardware transactional memory. As TSX is implemented as an extension (i.e., snooping the cache protocol), any unusual event, such as an exception or interrupt, that should be handled in its core component, results in an abort of the ongoing transaction. One interesting property is that the TSX abort suppresses the notification of errors to the underlying OS. This means that the OS cannot know whether a page fault has occurred during the transaction. T-SGX, by utilizing this property of TSX, can carefully isolate the effect of attempts to tap running enclaves, thereby completely eradicating the known controlled channel attack. We have implemented T-SGX as a compiler-level scheme to automatically transform a normal enclave program into a secured enclave program without requiring manual source code modification or annotation. We not only evaluate the security properties of T-SGX, but also demonstrate that it could be applied to all the previously demonstrated attack targets, such as libjpeg, Hunspell, and FreeType. To evaluate the performance of T-SGX, we ported 10 benchmark programs of nbench to the SGX environment. Our evaluation results look promising. T-SGX is an order of magnitude faster than the state-of-the-art mitigation schemes. On our benchmarks, T-SGX incurs on average 50% performance overhead and less than 30% storage overhead.
Influence of protein intake on renal hemodynamics and plasma hormone concentrations in normal subjects.

Glomerular filtration rate (GFR) by clearance of inulin and creatinine and effective renal plasma flow (ERPF) by para-aminohippurate clearance was investigated in 8 normal volunteers on low protein (LP) and high protein (HP) diet for 6 days in the basal state and after a mixed protein-rich test meal. Plasma immunoreactive insulin (IRI), glucagon (IRG) and growth hormone (IRHGH) were followed before and after the test meal. GFR was higher on HP than on LP diet and increased within one hour after the test meal. ERPF also increased significantly after the meal on LP diet. IRI increased maximally at 60 min after the test meal and then declined gradually. IRG increased after a latency period of 90 min and IRHGH consistently did not change. Since the increase in GFR was significant already one hour after the test meal, i.e. before IRG was changed, we conclude that glucagon is not a mediator of the protein-induced increased in GFR. Neither insulin nor growth hormone appeared to be involved.
Who Pays When Auction Rules are Bent

In many negotiations, rules are soft in the sense that the seller and/or buyers may break them at some cost. When buyers have private values, we show that the cost of such 'rule bending' is borne entirely by the seller in equilibrium. Consequently, the seller is willing to pay an intermediary to credibly commit to a mechanism in which no one has the ability or the incentive to cheat. Examples of costly rule bending considered here include hiring shill (fake) bidders and trying to learn others' bids before making one's own. Buyers may also invest in legitimate bidding software that can give them an advantage over buyers who enter bids manually and thus are slow to respond to changes in other's bids. In equilibrium, the cost of all such socially wasteful investments (whether made by the buyers or the seller) is passed through to the seller in the form of lower revenues.
Glutamatergic Inputs in the Hypothalamic Paraventricular Nucleus Maintain Sympathetic Vasomotor Tone in Hypertension

The paraventricular nucleus (PVN) of the hypothalamus is critical to the regulation of sympathetic output. The PVN hyperactivity is known to cause increased sympathetic nerve activity in spontaneously hypertensive rats (SHRs). The purpose of this study was to determine whether glutamatergic input to the PVN contributes to heightened sympathetic outflow in hypertension. Lumbar sympathetic nerve activity, mean arterial blood pressure, and heart rate were recorded from anesthetized SHRs and Wistar-Kyoto (WKY) rats. Bilateral microinjection of an N-methyl-D-aspartate receptor antagonist, 2-amino-5-phosphonopentanoic acid, or a non-N-methyl-D-aspartate receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione, into the PVN dose-dependently decreased lumbar sympathetic nerve activity, mean arterial blood pressure, and heart rate in SHRs but not in WKY rats. Bilateral microinjection of kynurenic acid into the PVN also significantly decreased lumbar sympathetic nerve activity, mean arterial blood pressure, and heart rate in SHRs but not in WKY rats. Furthermore, microinjection of gabazine, a specific GABAA receptor antagonist, into the PVN increased lumbar sympathetic nerve activity, mean arterial blood pressure, and heart rate in both SHRs and WKY rats. Notably, this response was significantly attenuated in SHRs compared with that in WKY rats. In addition, kynurenic acid abolished the sympathoexcitatory and pressor responses to microinjection of gabazine into the PVN in both SHRs and WKY rats. Thus, this study provides new functional evidence that resting sympathetic vasomotor tone is maintained by tonic glutamatergic input in the PVN in SHRs. Removal of GABAergic inhibition results in augmented glutamatergic input in the PVN, which probably constitutes an important source of excitatory drive to the brain stem vasomotor neurons in hypertension.
Nested PCR Assays for Detection of Blastomyces dermatitidis DNA in Paraffin-Embedded Canine Tissue

ABSTRACT A Blastomyces dermatitidis nested PCR assay targeting the gene encoding the Wisconsin 1 (WI-1) adhesin was developed and compared with a nested PCR targeting the 18S rRNA gene (rDNA) of members of the family Onygenaceae. We examined 73 paraffin-embedded tissue samples obtained from nine dogs which died of blastomycosis and nine dogs which succumbed to lymphosarcoma according to autopsy findings; amplifiable canine DNA was extracted from 25 and 33 specimens from the two groups, respectively. The B. dermatitidis PCR amplified DNA from 8 of 13 tissue samples in which yeast cells were detected by microscopy. Sequencing revealed that all PCR products were homologous to the B. dermatitidis WI-1 adhesin gene. No PCR product was amplified from 12 microscopically negative biopsy specimens from dogs with blastomycosis or from 33 biopsy specimens from dogs with lymphosarcoma. The 18S rDNA PCR amplified DNA from 10 and 9 tissue samples taken from dogs which died of blastomycosis and lymphosarcoma, respectively. Only six products were identified as being identical to B. dermatitidis 18S rDNA; they were exclusively obtained from specimens positive by the B. dermatitidis nested PCR. For specificity testing, 20 human biopsy specimens proven to have histoplasmosis were examined, and a specific H. capsulatum product was amplified by the 18S rDNA PCR from all specimens, whereas no product was obtained from any of the 20 samples by the B. dermatitidis PCR assay. In conclusion, the PCR targeting a gene encoding the unique WI-1 adhesin is as sensitive as but more specific than the PCR targeting the 18S rDNA for detection of B. dermatitidis in canine tissue.
The Affective Domain and the Writing Process: Working Definitions

Since the time of classical Greece, we have been accustomed to viewing humans as both thinking and feeling individuals. The dichotomy of cognition and affect is so ingrained in Western thought that it seems a natural one; the two elements have seldom, however, been deemed equally important in the scientific community. During the nineteenth century and early twentieth century, psychology gave primacy to affect; humans were thought to be at the mercy of various drives and passions. As behaviorism became more domi nant in the field, affect was discounted; indeed, there were those who wished to exclude affect from scientific study altogether (Brown and Farber; Duffy). More recently, with the ascendancy of cognitive psychology, humans have been viewed as problem-solvers whose thinking processes operate rather like a computer. Often in such a view, affect is seen as "a regrettable flaw in an otherwise perfect cognitive machine" (Scherer 293). But most researchers who study human behavior and human nature agree that the views of both extremes? emphasizing only affect or only cognition? are undesirable. As Vygotsky said, the separation of affect from cognition
The influence of wind direction on natural ventilation: application to a large semi-enclosed stadium

Natural ventilation is still a commonly applied way in building engineering to ensure a healthy and comfortable indoor climate. In this paper CFD simulations of the natural ventilation of a large semi-enclosed stadium in the Netherlands during the summer are described. Simulations are performed to assess the air exchange rate for a total of eight wind directions. The CFD model consists of both the complex stadium geometry and the urban environment in which the stadium is located. Validation of the CFD model is performed using full-scale 3D wind velocity measurements, furthermore, a grid sensitivity analysis is conducted. Comparison of the calculated air exchange rates showed that the wind direction has a significant effect on the air exchange rate; differences up to 100% were found for the air exchange rate, which can be explained by looking at the presence and size of the buildings that are situated upstream of the stadium.
Simultaneous Measurement of Cerebral Blood Flow and Unidirectional Movement of Substances Across the Blood‐Brain Barrier: Theory, Method, and Application to Leucine

Abstract: The uptake of compounds by the brain depends upon cerebral blood flow. To determine the normal blood flow‐cerebral extraction relationship, a method for rapid, simultaneous measurement of cerebral blood flow and brain extraction was developed and applied to blood‐brain leucine transfer. Awake rats were injected intravenously with a mixture of n‐[14C]butanol and [3H]leucine. The quantities of indicators accumulated over the following 5–12 s in brain and in a sample of arterial blood withdrawn at a known rate were used to determine the flux of butanol and leucine into brain. Butanol extraction was assessed independently by measuring arterial and cerebral venous concentrations of the indicator after a bolus injection. Cerebral blood flow was equal to the ratio of butanol flux into brain to butanol extraction by brain; leucine extraction was then calculated as the ratio of leucine influx to cerebral blood flow. Leucine extraction by brain and cerebral blood flow were shown to be related exponentially. The maximum velocity of active leucine transport was virtually the same at flows of 150 and 400 ml/100 g/min. The present method is theoretically applicable to the measurement of the extraction of any compound from blood by brain. By measuring the noimal blood flow‐extraction relationship, one can differentiate changes in extraction secondary to altered flow from changes intrinsic to pathologic conditions with inconstant cerebral blood flow.
Aspects of plastic deformation of PET-steel laminates

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Pulmonary Vein Isolation for Paroxysmal and Persistent Atrial Fibrillation

Background—The pulmonary veins (PVs) have been demonstrated to often play an important role in generating atrial fibrillation (AF). The purpose of this study was to determine the safety and efficacy of segmental PV isolation in patients with paroxysmal or persistent AF. Methods and Results—In 70 consecutive patients (mean age, 53±11 years) with paroxysmal (58) or persistent (12) AF, segmental PV isolation guided by ostial PV potentials was performed. The left superior, left inferior, and right superior PVs were targeted for isolation in all patients, and the right inferior PV was isolated in 20 patients. Among the 230 targeted PVs, 217 (94%) were completely isolated, with a mean of 6.5±4.2 minutes of radiofrequency energy applied at a maximum power setting of 35 W. A second PV isolation procedure was performed in 6 patients (9%). At 5 months of follow-up, 70% of patients with paroxysmal and 22% of patients with persistent AF were free from recurrent AF (P <0.001), and 83% of patients with paroxysmal AF were either free of symptomatic AF or had significant improvement. Among various clinical characteristics, only paroxysmal AF was an independent predictor of freedom from recurrence of AF (P <0.05). One patient developed unilateral quadrantopsia after the procedure. There were no other complications. Conclusions—With a segmental isolation approach that targets at least 3 PVs, a clinically satisfactory result can be achieved in >80% of patients with paroxysmal AF. The clinical efficacy of pulmonary vein isolation is much lower when AF is persistent than when it is paroxysmal.
LINE-EMITTING GALAXIES BEYOND A REDSHIFT OF 7: AN IMPROVED METHOD FOR ESTIMATING THE EVOLVING NEUTRALITY OF THE INTERGALACTIC MEDIUM

The redshift-dependent fraction of color-selected galaxies revealing Lyman alpha (Lyα) emission, xLyα has become the most valuable constraint on the evolving neutrality of the early intergalactic medium. However, in addition to resonant scattering by neutral gas, the visibility of Lyα is also dependent on the intrinsic properties of the host galaxy, including its stellar population, dust content, and the nature of outflowing gas. Taking advantage of significant progress we have made in determining the line-emitting properties of z ≃ 4–6 galaxies, we propose an improved method, based on using the measured slopes of the rest-frame ultraviolet continua of galaxies, to interpret the growing body of near-infrared spectra of z > 7 galaxies in order to take into account these host galaxy dependencies. In a first application of our new method, we demonstrate its potential via a new spectroscopic survey of 7 < z < 8 galaxies undertaken with the Keck MOSFIRE spectrograph. Together with earlier published data, our data provide improved estimates of the evolving visibility of Lyα, particularly at redshift z ≃ 8. As a by-product, we also present a promising new line-emitting galaxy candidate, detected at 4. 0σ at redshift z = 7.62. We discuss the improving constraints on the evolving neutral fraction over 6 < z < 8 and the implications for cosmic reionization.
Using Stationarity Tests in Antitrust Market Definition

In this Paper it is argued that, if two products or geographic areas belong in the same market, their relative price must be stationary. Hence stationarity tests like the ADF and the KPSS can be helpful in delineating the relevant market for Antitrust purposes, particularly for abuses of dominant positions and agreements between competitors. The proposed procedure is closely related with cointegration analysis but has more general validity. An application to the Italian milk market illustrates the technique.
Structure and blood compatibility of highly oriented PLA/MWNTs composites produced by solid hot drawing

Highly oriented poly(lactic acid) (PLA)/multi-walled carbon nanotubes (MWNTs) composites were fabricated through solid hot drawing technology in an effort to improve the mechanical properties and blood biocompatibility of PLA as blood-contacting medical devices. It was found that proper MWNTs content and drawing orientation can improve the tensile strength and modulus of PLA dramatically. With the increase in draw ratio, the cold crystallization peak became smaller, and the glass transition and the melting peak of PLA moved to high temperature, while the crystallinity increased, and the grain size decreased, indicating the stress-induced crystallization of PLA during drawing. MWNTs showed a nucleation effect on PLA, leading to the rise in the melting temperature, increase in crystallinity and reduction of spherulite size for the composites. Moreover, the intensity of (002) diffraction of MWNTs increased with draw ratio, indicating that MWNTs were preferentially aligned and oriented during drawing. Microstructure observation demonstrated that PLA matrix had an ordered fibrillar bundle structure, and MWNTs in the composite tended to align parallel to the drawing direction. In addition, the dispersion of MWNTs in PLA was also improved by orientation. Introduction of MWNTs and drawing orientation could significantly enhance the blood compatibility of PLA by prolonging kinetic clotting time, reducing hemolysis ratio and platelet activation.
The Development of Aromas in Ruminant Meat

This review provides an update on our understanding of the chemical reactions (lipid oxidation, Strecker and Maillard reactions, thiamine degradation) and a discussion of the principal aroma compounds derived from those reaction or other sources in cooked meat, mainly focused on ruminant species. This knowledge is essential in order to understand, control, and improve the quality of food products. More studies are necessary to fully understand the role of each compound in the overall cooked meat flavour and their possible effect in consumer acceptability.