Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of age and intake on vitamin C disposition in females.

The pharmacokinetics of vitamin C following a 500 mg oral tablet dose were compared in a group of fourteen healthy young women whose age was 26.0 +/- 2.8 years (mean +/- s.d.), and in a group of fourteen healthy elderly women aged 68.1 +/- 2.6 years. The body composition of each subject was assessed using several anthropometric measurements in order to help explain any observed differences in the pharmacokinetic behavior of vitamin C. The vitamin C doses were characterized with the subjects in two states of vitamin C nutriture: a 'depleted' state which was achieved by 4-5 weeks on a vitamin C-restricted diet of less than 10 mg/d and a 'supplemented' state in which the subjects were given daily doses of 500 mg of vitamin C for 3 weeks. Plasma and urine samples were collected for 72 h following the dose of vitamin C from subjects in a 'depleted' state and for 24 h from subjects in a 'supplemented' state and analysed for their vitamin C content. None of the pharmacokinetic parameters measured differed significantly between the two age groups. In contrast, the vast majority of these parameters were significantly different in depleted and supplemented subjects. The peak times (tmax) were greater in the depleted state in both young and elderly groups whereas the peak concentrations (Cmax) were greater in the supplemented state. The absorption rate constant (Ka) was significantly larger in the supplemented state compared to the depleted state in the young group and the absorption half-life (t 1/2, Ka) was significantly greater in the depleted state in the young group only. The absorption lag time (tlag) did not differ with respect to age or nutritional status. The elimination half-life (t 1/2, Ke) was significantly longer in supplemented subjects. Although the apparent high volume of distribution (Vd) was not significantly different within each age group the Vd was significantly greater in the depleted state when the two age groups were combined. The clearance (CL), and the nonrenal clearance (CLNR) were significantly greater in the depleted state. The renal clearance (CLR) and the amounts of vitamin C excreted in the 0- to 12- and 12- to 24-h intervals were significantly larger in the supplemented state. The urinary excretion data also indicate that, in supplemented subjects, an average of about 40 percent of the administered dose is excreted as unchanged vitamin C in the first 12 h after dosing, with very little being excreted thereafter.
Comparison of Zotarolimus- and Everolimus-Eluting Coronary Stents

Background—Newer-generation drug-eluting stents that release zotarolimus or everolimus have been shown to be superior to the first-generation drug-eluting stents. However, data comparing long-term safety and efficacy of zotarolimus- (ZES) and everolimus-eluting stents (EES) are limited. RESOLUTE all-comers (Randomized Comparison of a Zotarolimus-Eluting Stent With an Everolimus-Eluting Stent for Percutaneous Coronary Intervention) trial compared these 2 stents and has shown that ZES was noninferior to EES at 12-month for the primary end point of target lesion failure. We report the secondary clinical outcomes at the final 5-year follow-up of this trial. Methods and Results—RESOLUTE all-comer clinical study is a prospective, multicentre, randomized, 2-arm, open-label, noninferiority trial with minimal exclusion criteria. Patients (n=2292) were randomly assigned to treatment with either ZES (n=1140) or EES (n=1152). Patient-oriented composite end point (combination of all-cause mortality, myocardial infarction, and any revascularizations), device-oriented composite end point (combination of cardiac death, target vessel myocardial infarction, and clinically indicated target lesion revascularization), and major adverse cardiac events (combination of all-cause death, all myocardial infarction, emergent coronary bypass surgery, or clinically indicated target lesion revascularization) were analyzed at 5-year follow-up. The 2 groups were well-matched at baseline. Five-year follow-up data were available for 98% patients. There were no differences in patient-oriented composite end point (ZES 35.3% versus EES 32.0%, P=0.11), device-oriented composite end point (ZES 17.0% versus EES 16.2%, P=0.61), major adverse cardiac events (ZES 21.9% versus EES 21.6%, P=0.88), and definite/probable stent thrombosis (ZES 2.8% versus EES 1.8%, P=0.12). Conclusions—At 5-year follow-up, ZES and EES had similar efficacy and safety in a population of patients who had minimal exclusion criteria. Clinical Trial Registration—URL: http://www.clinicaltrials. gov. Unique identifier: NCT00617084.
Can Life Begin on Enceladus? A Perspective from Hydrothermal Chemistry

Abstract Enceladus is a target of future missions designed to search for existing life or its precursors. Recent flybys of Enceladus by the Cassini probe have confirmed the existence of a long-lived global ocean laced with organic compounds and biologically available nitrogen. This immediately suggests the possibility that life could have begun and may still exist on Enceladus. Here we will compare the properties of two proposed sites for the origin of life on Earth—hydrothermal vents on the ocean floor and hydrothermal volcanic fields at the surface—and ask whether similar conditions could have fostered the origin of life on Enceladus. The answer depends on which of the two sites would be more conducive for the chemical evolution leading to life's origin. A hydrothermal vent origin would allow life to begin in the Enceladus ocean, but if the origin of life requires freshwater hydrothermal pools undergoing wet-dry cycles, the Enceladus ocean could be habitable but lifeless. These arguments also apply directly to Europa and indirectly to early Mars. Key Words: Enceladus—Hydrothermal vents—Hydrothermal fields—Origin of life. Astrobiology 17, 834–839.
Bortezomib use in a pediatric cardiac transplant center

Data are limited on the efficacy and safety of bortezomib for the treatment of AMR following OHT for pediatric acquired or CHD. Retrospective chart review identified patients who received bortezomib for acute (n = 3, within two wk of diagnosis) and chronic (n = 1, three months after diagnosis) AMR or as part of a desensitization regimen (n = 1). Bortezomib was associated with a 3–66% reduction in class I DSA and a 7–82% reduction in class II DSA. Two of the three acute AMR cases resolved by the first follow‐up biopsy. Two patients with AMR resolution are currently well. One patient developed a second episode of AMR, which was unresponsive to bortezomib therapy and required retransplantation for progressive coronary allograft vasculopathy. One patient died shortly after the third cycle from multi‐organ failure. The desensitization patient showed transient HLA reduction with two cycles, but died five months after transplant from sepsis. Complications included infection (3/5), peripheral neuropathy (2/5), AKI (2/5), and thrombocytopenia (3/5). Adverse events appear more common in critically ill patients. Bortezomib therapy resulted in variable DSA reduction and AMR resolution in AMR in OHT secondary to pediatric acquired or CHD.
Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection.

BACKGROUND All-oral combination therapy is desirable for patients with chronic hepatitis C virus (HCV) infection. We evaluated daclatasvir (an HCV NS5A replication complex inhibitor) plus sofosbuvir (a nucleotide analogue HCV NS5B polymerase inhibitor) in patients infected with HCV genotype 1, 2, or 3. METHODS In this open-label study, we initially randomly assigned 44 previously untreated patients with HCV genotype 1 infection and 44 patients infected with HCV genotype 2 or 3 to daclatasvir at a dose of 60 mg orally once daily plus sofosbuvir at a dose of 400 mg orally once daily, with or without ribavirin, for 24 weeks. The study was expanded to include 123 additional patients with genotype 1 infection who were randomly assigned to daclatasvir plus sofosbuvir, with or without ribavirin, for 12 weeks (82 previously untreated patients) or 24 weeks (41 patients who had previous virologic failure with telaprevir or boceprevir plus peginterferon alfa-ribavirin). The primary end point was a sustained virologic response (an HCV RNA level of <25 IU per milliliter) at week 12 after the end of therapy. RESULTS Overall, 211 patients received treatment. Among patients with genotype 1 infection, 98% of 126 previously untreated patients and 98% of 41 patients who did not have a sustained virologic response with HCV protease inhibitors had a sustained virologic response at week 12 after the end of therapy. A total of 92% of 26 patients with genotype 2 infection and 89% of 18 patients with genotype 3 infection had a sustained virologic response at week 12. High rates of sustained virologic response at week 12 were observed among patients with HCV subtypes 1a and 1b (98% and 100%, respectively) and those with CC and non-CC IL28B genotypes (93% and 98%, respectively), as well as among patients who received ribavirin and those who did not (94% and 98%, respectively). The most common adverse events were fatigue, headache, and nausea. CONCLUSIONS Once-daily oral daclatasvir plus sofosbuvir was associated with high rates of sustained virologic response among patients infected with HCV genotype 1, 2, or 3, including patients with no response to prior therapy with telaprevir or boceprevir. (Funded by Bristol-Myers Squibb and Pharmasset (Gilead); A1444040 ClinicalTrials.gov number, NCT01359644. ).
Phosphate Import in Plants: Focus on the PHT1 Transporters

The main source of phosphorus for plants is inorganic phosphate (Pi), which is characterized by its poor availability and low mobility. Uptake of this element from the soil relies heavily upon the PHT1 transporters, a specific family of plant plasma membrane proteins that were identified by homology with the yeast PHO84 Pi transporter. Since the discovery of PHT1 transporters in 1996, various studies have revealed that their function is controlled by a highly complex network of regulation. This review will summarize the current state of research on plant PHT1 multigenic families, including physiological, biochemical, molecular, cellular, and genetics studies.
Effectiveness of an oral health program for mothers and their infants.

BACKGROUND The baby oral health program (bOHP) provides pregnant women and their future babies with oral care. AIM To assess the bOHP effectiveness by comparing caries prevalence in infants enrolled and not enrolled in the oral health program (OHP). DESIGN Mothers who had been invited to participate in the bOHP from 2006 to 2009 were contacted. Two groups were formed: 87 pairs of mothers and infants who effectively participated in the OHP (G1) and 107 pairs who did not (G2). Mothers and infants were given a dental examination. Socio-economic status (SES) and education level (EL) questionnaires were completed. t-tests and multivariate logistic regression were used in analyzing data. RESULTS Statistically significant differences were observed in the mean age of mothers (G1 = 33.8 years; G2 = 35.6 years; P = 0.015) and mean decayed, missed and filled surface (DMFS) score (G1 = 24.71; G2 = 32.58; P < 0.001), not in SES (P = 0.758) and EL (P = 0.109). Mean age and mean dmfs scores of G1 and G2 children were 4.2 and 4.4 years (P = 0.068), and 0.25 and 4.12 (P < 0.001), respectively. The odds ratio (OR) for children in G2 to develop dentine lesions, as opposed to those in G1, was 48.56. CONCLUSION The bOHP was effective in preventing caries in infants enrolled in the program.
A Quality Use of Medicines program for continuity of care in therapeutics from hospital to community

TO THE EDITOR: It is refreshing to see quality initiatives like that of Mant et al,1 which examine issues of continuity across different territories. Use of a simple audit tool (minimum dataset) and methodology has worked well to illuminate what misleadingly appears to be a simple problem (ie, the two-way exchange of information between the hospital and general practitioner in relation to medication). Unfortunately, like many problems that appear straightforward and easily fixable, the reality is that this issue is far more complex to address. A lack of clinical governance has been made apparent in both the public hospitals and the Divisions of General Practice that participated. Clinical governance demands that organisations be accountable for standards and performance in relation to clinical care,2 and this is integral to addressing problems both internally and across the continuum of care. Mant et al demonstrated that many hospitals had policies and strategies to accomplish the exchange of medication information,1 indicating that these procedures were thought to be achievable with current resources. Before this study, knowledge among staff of implementation was scant and confused, and there was no system of review to reveal existing problems. When problems were exposed and changes made, staff were not upskilled to incorporate the change into their practice (eg, junior doctors not completing the new discharge referral form). Similarly, the Divisions of General Practice did not resolve issues surrounding the production and distribution of business cards that they had agreed to undertake. This study has determined a means to measure performance and has intervened to analyse problems and yield some improvements. However, if the organisations involved do not commit to develop clinical governance, the path towards continued improvement will be extremely slow (if at all) and the findings of this project made irrelevant.
Optimal Assignment of Multiskilled Labor in Building Construction Projects

The utilization of multiskilled construction workers has increased in recent years in order to improve the efficiency of resource utilization in construction projects. The successful application of this strategy requires thoughtful assignments of available multiskilled workers to appropriate tasks in construction projects. An optimization model was developed to support field management personnel in this challenging task in order to minimize the total labor cost of the project. The model was designed to consider all practical constraints and limitations involved in this assignment problem, including workers' skill, productivity, and availability constraints. A spreadsheet solver that comes bundled with Microsoft Excel™ was used for the implementation of the model due to its wide availability and ease of use. An application example was analyzed to illustrate the performance of the present model relative to that of an existing model obtained from the literature. The two models were compared with respect to the quality of solutions obtained, and model computational complexity.
Procedural Justice and Survivors Reactions to Job Layoffs

Abstract Behavioral decision theory suggests that the perceived favorability of outcomes depends on how they are framed. Recent research in the justice literature suggests that perceived outcome favorability and procedural fairness interactively combine to influence employees′ reactions to a resource allocation decision. The present study tested a hypothesis derived from the integration of these two literatures: that decision frame-by affecting perceived outcome favorability-would interact with procedural fairness to influence individuals′ reactions to the decision. All participants were layoff survivors; the primary dependent variable was their trust in and support for the organization subsequent to the layoff. Through a framing manipulation, half evaluated the criteria that the organization used to keep certain employees rather than others (Keep condition), whereas the other half judged the criteria that the organization used to dismiss certain employees rather than others (Dismiss condition). Survivors also evaluated the procedural fairness of the layoff. As predicted, decision frame and procedural fairness interacted to influence survivors′ trust in and support for the organization. When procedural fairness was low, survivors reacted more favorably in the positive frame (Keep) than in the negative frame (Dismiss) condition. When procedural fairness was high, however, decision frame had no effect on survivors′ reactions. Possible explanations of the findings, as well as their theoretical and practical implications, are discussed.
A novel high-speed binary and gray Incrementer/Decrementer for an address generation unit

An incrementer/decrementer (INC/DEC) is a common building block in many digital systems like address generation unit which are used in microcontrollers and microprocessors. In this paper, novel architectures and designs for binary and gray INC/DECs are presented which faster than the existing ones without compromising in terms of power. The proposed architectures lay an emphasis on the usage of hybrid logic, that is, coupling of transmission gate with CMOS gates at appropriate stages for efficient design. Also, efficient utilization of the output and its complement, available in all existing implementations of gates, is done by using multiplexers in the proposed gray INC/DEC. For a 32-bit input, the proposed binary and gray INC/DEC achieve an improvement of 47%, 33% in delay and reduction of 38%, 28% in power-delay product respectively.
DETECTION OF PLASMA MEMBRANE CARBOHYDRATES WITH LECTIN PEROXIDASE CONJUGATES

With the use of the cytochemical stain for horseradish peroxidase of Graham and Karnovsky (1966. J. Histochem. Cytochem. 14:291), conjugates of horseradish peroxidase with ricin, wheat germ agglutinin, and phytohemagglutinin were employed for the morphologic demonstration of d-galactose (ricin), N-acetylglucosamine (wheat germ), and N-acetylgalactosamine (phytohemagglutinin) containing moieties on the surface of unfixed, or paraformaldehyde-fixed rat lymphoid cells. D-Galactose, or d-galactose containing disaccharides inhibited the interaction between ricin peroxidase and lymphoid cell surface; also, N-acetylglucosamine inhibited the wheat germ peroxidase-lymphoid cell interaction, but N-acetylgalactosamine failed to inhibit the reaction between phytohemagglutinin peroxidase and the surface of lymphoid cells.
New horizons in microbiological food safety: Photodynamic Decontamination based on a curcumin derivative

Outbreaks of foodborne diseases are regularly reported worldwide. In particular, uncooked plant food is considered risky in terms of microbiological safety. Food is also the most important transmission route for resistant microorganisms from animals to humans. Photodynamic Decontamination (PDc) of foodstuff was recently introduced as a novel approach for increasing microbiological food safety. We investigated the efficiency of PDc on plant food with different geometries (flat, spherical and complex) using a two-dimensional LED array as a light source (435 nm, 33.8 J cm^−2) and the cationic curcumin derivative SACUR-3 as a photosensitiser. A photoantibacterial effect (>3 log_10 CFU reduction) was achieved on all flat substrates (slices of cucumber, tomato and lettuce) with 10 pM, 50 pM or 100 pM SACUR-3. The maximal photokilling with a relative inactivation of 5. 6log_10 was measured on lettuce using 50 pM of the photoactive compound. Phototreatment of non-germinated fenugreek seeds and mung beans was successful if the spherical objects were rotated while under illumination (antibacterial effect at 100 pM SACUR-3). The decontamination of mung bean germlings with a more complex geometry using the PDc approach was inefective with the two-dimensional light source. In conclusion, PDc based on the cationic curcumin derivative SACUR-3 is very efective at improving the microbiological safety of plant food with a flat or spherical geometry. More complex objects will require the development of novel illumination devices.
Standard forms and entanglement engineering of multimode Gaussian states under local operations

We investigate the action of local unitary operations on multimode (pure or mixed) Gaussian states and single out the minimal number of locally invariant parameters which completely characterize the covariance matrix of such states. For pure Gaussian states, central resources for continuous-variable quantum information, we investigate separately the parameter reduction due to the additional constraint of global purity, and the one following by the local-unitary freedom. Counting arguments and insights from the phase-space Schmidt decomposition and in general from the framework of symplectic analysis, accompany our description of the standard form of pure n-mode Gaussian states. In particular, we clarify why only in pure states with n ⩽ 3 modes all the direct correlations between position and momentum operators can be set to zero by local unitary operations. For any n, the emerging minimal set of parameters contains complete information about all forms of entanglement in the corresponding states. An efficient state engineering scheme (able to encode direct correlations between position and momentum operators as well) is proposed to produce entangled multimode Gaussian resources, its number of optical elements matching the minimal number of locally invariant degrees of freedom of general pure n-mode Gaussian states. Finally, we demonstrate that so-called ‘block-diagonal’ Gaussian states, without direct correlations between position and momentum, are systematically less entangled, on average, than arbitrary pure Gaussian states.
Effect of Low Concentration Sn Doping on Optical Properties of CdS Films Grown by CBD Technique

Thin and transparent films of doped cadmium sulfide (CdS) were obtained on commercial glass substrates by Chemical Bath Deposition (CBD) technique. The films were doped with low concentration of Sn, and annealed in air at 300 °C for 45 min. The morphological characterization of the films with different amounts of dopant was made using SEM and EDAX analysis. Optical properties of the films were evaluated by measuring transmittance using the UV-vis spectrophotometer. A comparison of the results revealed that lower concentration of Sn doping improves transmittance of CdS films and makes them suitable for application as window layer of CdTe/CIGS solar cells.
Single View Point Omnidirectional Camera Calibration from Planar Grids

This paper presents a flexible approach for calibrating omnidirectional single viewpoint sensors from planar grids. These sensors are increasingly used in robotics where accurate calibration is often a prerequisite. Current approaches in the field are either based on theoretical properties and do not take into account important factors such as misalignment or camera-lens distortion or over-parametrised which leads to minimisation problems that are difficult to solve. Recent techniques based on polynomial approximations lead to impractical calibration methods. Our model is based on an exact theoretical projection function to which we add well identified parameters to model real-world errors. This leads to a full methodology from the initialisation of the intrinsic parameters to the general calibration. We also discuss the validity of the approach for fish-eye and spherical models. An implementation of the method is available as OpenSource software on the author's Web page. We validate the approach with the calibration of parabolic, hyperbolic, folded mirror, wide-angle and spherical sensors.