Miracle-dz/UniFAR-FTUs huggingface dataset:
Absolute vs Relative Performance Rating Formats: Implications for Fairness and Organizational Justice

The choice of performance rating format may influence employees' fairness perceptions. Participants in two studies, one consisting of 208 participants and the other of 393 participants, evaluated the fairness of common relative and absolute rating formats. The participants in the second study also evaluated the fairness of two rating formats, one absolute and one relative, presented in organizational contexts of varying procedural and distributive justice. Results indicate that not only are absolute formats perceived as more fair than relative formats, but differences in fairness perceptions also occur among relative and absolute formats. Furthermore, it appears that rating format influences procedural justice, especially when outcomes are perceived as fair. Implications for organizations' appraisal practices are discussed.
Network and Atomistic Simulations Unveil the Structural Determinants of Mutations Linked to Retinal Diseases

A number of incurable retinal diseases causing vision impairments derive from alterations in visual phototransduction. Unraveling the structural determinants of even monogenic retinal diseases would require network-centered approaches combined with atomistic simulations. The transducin G38D mutant associated with the Nougaret Congenital Night Blindness (NCNB) was thoroughly investigated by both mathematical modeling of visual phototransduction and atomistic simulations on the major targets of the mutational effect. Mathematical modeling, in line with electrophysiological recordings, indicates reduction of phosphodiesterase 6 (PDE) recognition and activation as the main determinants of the pathological phenotype. Sub-microsecond molecular dynamics (MD) simulations coupled with Functional Mode Analysis improve the resolution of information, showing that such impairment is likely due to disruption of the PDEγ binding cavity in transducin. Protein Structure Network analyses additionally suggest that the observed slight reduction of theRGS9-catalyzed GTPase activity of transducin depends on perturbed communication between RGS9 and GTP binding site. These findings provide insights into the structural fundamentals of abnormal functioning of visual phototransduction caused by a missense mutation in one component of the signaling network. This combination of network-centered modeling with atomistic simulations represents a paradigm for future studies aimed at thoroughly deciphering the structural determinants of genetic retinal diseases. Analogous approaches are suitable to unveil the mechanism of information transfer in any signaling network either in physiological or pathological conditions.
THE COMPREHENSION OF TENSE BY YOUNG CHILDREN

It was found that the present, past, and future tenses were comprehended by children aged 3 years when an unfamiliar referent (a performing toy) and a nonsense verb were used. The past and future tenses were comprehended when presented paired with each other, but not when paired with the present tense. These results were attributed to the factor of attention. A second experiment showed that the future tense paired with the present was not comprehended till the age of 6, and only at the age of 5 when additional grammatical and referential cues were given.
The State of Psychological Ownership: Integrating and Extending a Century of Research

People develop feelings of ownership for a variety of objects, material and immaterial in nature. We refer to this state as psychological ownership. Building on and extending previous scholarship, the authors offer a conceptual examination of this construct. After defining psychological ownership, they address “why” it exists and “how” it comes into being. They propose that this state finds its roots in a set of intraindividual motives (efficacy and effectance, self-identity, and having a place to dwell). In addition, they discuss the experiences that give rise to psychological ownership and propose several positive and negative consequences of this state. The authors’ work provides a foundation for the development of a comprehensive theory of psychological ownership and the conceptual underpinnings for empirical testing.
Age Changes in the Ability to Interpret Affect in Sung and Instrumentally-Presented Melodies

The purpose of this study was to determine the age at which children begin to recognise the affective qualities in sung and instrumentally-presented melodies. Four, seven, and nine-year-old children who had been pretested for comprehension of emotional concepts listened to melodies that had been rated by adults as either (1) happy, (2) sad, (3) angry, or (4) frightened- sounding. The melodies were presented in two modalities: soprano voice singing nonsense syllables, and viola. Overall volume levels were held constant, although many other features were varied. The data indicated that thete are age changes in this ability, that modality does in some instances play a role in emotional comprehension, and that some of the emotions are easier to interpret than others. There are also interaction effects among the factors.
DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment

Male mammals produce sperm for most of postnatal life and therefore require a robust germ line stem cell system, with precise balance between self-renewal and differentiation. Prior work established doublesex- and mab-3-related transcription factor 1 (Dmrt1) as a conserved transcriptional regulator of male sexual differentiation. Here we investigate the role of Dmrt1 in mouse spermatogonial stem cell (SSC) homeostasis. We find that Dmrt1 maintains SSCs during steady state spermatogenesis, where it regulates expression of Plzf, another transcription factor required for SSC maintenance. We also find that Dmrt1 is required for recovery of spermatogenesis after germ cell depletion. Committed progenitor cells expressing Ngn3 normally do not contribute to SSCs marked by the Id4-Gfp transgene, but do so when spermatogonia are chemically depleted using busulfan. Removal of Dmrt1 from Ngn3-positive germ cells blocks the replenishment of Id4-GFP-positive SSCs and recovery of spermatogenesis after busulfan treatment. Our data therefore reveal that Dmrt1 supports SSC maintenance in two ways: allowing SSCs to remain in the stem cell pool under normal conditions; and enabling progenitor cells to help restore the stem cell pool after germ cell depletion.
Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysis

Atypical teratoid rhabdoid tumor (ATRT) is a rare central nervous system malignancy with a poor prognosis that affects mostly young children. Although radiotherapy (RT) historically has been delayed in patients aged <3 years, emerging evidence suggests a role for RT to achieve long‐term survivorship. Clinical features and age‐dependent trends of RT use were evaluated for patients with ATRT.
Illness perceptions and coping explain well-being in patients with Huntington's disease

This study sought to investigate the contribution of illness perceptions and coping mechanisms to the explanation of well-being of patients with Huntington's disease (HD). We investigated the Leventhal et al. assumption of the Self-regulation Model that coping mediates the relationship between illness perceptions and patients’ well-being. Illness perceptions, coping, and well-being in 77 HD patients were assessed with validated questionnaires; motor performance and cognitive performance were assessed with Huntington's disease-specific measures. The assumption that illness perceptions influence HD patients’ well-being via coping was not supported. The results indicate that both coping and illness perceptions made a major contribution to the explanation of variance in HD patients’ psychosocial well-being. Variance in their physical well-being was explained by illness perceptions mainly. The need to conduct further research on the interrelationships between illness perceptions, coping, and well-being in this patient category is discussed.
The Hereditary Hemochromatosis Protein, HFE, Specifically Regulates Transferrin-mediated Iron Uptake in HeLa Cells*

HFE is the protein product of the gene mutated in the autosomal recessive disease hereditary hemochromatosis (Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R. J., Ellis, M. C., Fullan, A., Hinton, L. M., Jones, N. L., Kimmel, B. E., Kronmal, G. S., Lauer, P., Lee, V. K., Loeb, D. B., Mapa, F. A., McClelland, E., Meyer, N. C., Mintier, G. A., Moeller, N., Moore, T., Morikang, E., Prasss, C. E., Quintana, L., Starnes, S. M., Schatzman, R. C., Brunke, K. J., Drayna, D. T., Risch, N. J., Bacon, B. R., and Wolff, R. R. (1996)Nat. Genet. 13, 399–408). At the cell surface, HFE complexes with transferrin receptor (TfR), increasing the dissociation constant of transferrin (Tf) for its receptor 10-fold (Gross, C. N., Irrinki, A., Feder, J. N., and Enns, C. A. (1998)J. Biol. Chem. 273, 22068–22074; Feder, J. N. , Penny, D. M. , Irrinki, A. , Lee, V. K. , Lebron, J. A. , Watson, N. , Tsuchihashi, Z. , Sigal, E. , Bjorkman, P. J., and Schatzman, R. C. (1998) Proc. Natl. Acad. Sci. U S A95, 1472–1477). HFE does not remain at the cell surface, but traffics with TfR to Tf-positive internal compartments (Gross et al., 1998). Using a HeLa cell line in which the expression of HFE is controlled by tetracycline, we show that the expression of HFE reduces 55Fe uptake from Tf by 33% but does not affect the endocytic or exocytic rates of TfR cycling. Therefore, HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments. HFE specifically reduces iron uptake from Tf, as non-Tf-mediated iron uptake from Fe-nitrilotriacetic acid is not altered. These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf-mediated pathway of iron uptake. These results also have implications for the understanding of cellular iron homeostasis in organs such as the liver, pancreas, heart, and spleen that are iron loaded in hereditary hemochromatotic individuals lacking functional HFE.
BRCA2 mutation in a family with hereditary prostate cancer

Hereditary prostate cancer is a genetically heterogeneous disease, and so far four different susceptibility loci have been identified. Reports of associated cancers are few, and it is generally considered a site‐specific disease. However, some reports have shown an elevated risk for prostate cancer among BRCA2 mutation carriers. In this report, we present a family in which the father and four of his sons were diagnosed with prostate cancer at exceptionally early ages (51, 52, 56, 58, and 63 years, respectively). In addition, three daughters were diagnosed with breast cancer between the ages of 47 and 61. In this family, a truncating mutation in exon 11, 6051delA of the BRCA2 gene, leading to an early termination of the protein (codon 1962), was identified. Although BRCA2 is probably responsible only for a very small fraction of hereditary prostate cancers, this finding supports previous reports of an increased risk of prostate cancer in BRCA2 mutation carriers. © 2001 Wiley‐Liss, Inc.
Functional amino acids and fatty acids for enhancing production performance of sows and piglets

The growth and health of the fetus and neonate are directly influenced by the nutritional and physiological status of sows. Sows are often under catabolic conditions due to restrict feeding program during pregnancy and low voluntary feed intake during lactation. The current restrict feeding program, which aims at controlling energy intake during gestation, results in an inadequate supply of dietary protein for fetal and mammary gland growth. Low voluntary feed intake during lactation also causes massive maternal tissue mobilization. Provision of amino acids and fatty acids with specific functions may enhance the performance of pregnant and lactating sows by modulating key metabolic pathways. These nutrients include arginine, branched-chain amino acids, glutamine, tryptophan, proline, conjugated linoleic acids, docosahexaenoic acid, and eicosapentaenoic acid, which can enhance conception rates, embryogenesis, blood flow, antioxidant activity, appetite, translation initiation for protein synthesis, immune cell proliferation, and intestinal development. The outcome is to improve sow reproductive performance as well as fetal and neonatal growth and health. Dietary supplementation with functional amino acids and fatty acids holds great promise in optimizing nutrition, health, and production performance of sows and piglets. (Supported by funds from Texas Tech, USDA, NLRI-RDA-Korea, and China NSF).
First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan–Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors

Purpose: This first-in-human dose-escalation trial evaluated the safety, tolerability, maximal-tolerated dose (MTD), dose-limiting toxicities (DLT), pharmacokinetics, pharmacodynamics, and preliminary clinical activity of pictilisib (GDC-0941), an oral, potent, and selective inhibitor of the class I phosphatidylinositol-3-kinases (PI3K). Patients and Methods: Sixty patients with solid tumors received pictilisib at 14 dose levels from 15 to 450 mg once-daily, initially on days 1 to 21 every 28 days and later, using continuous dosing for selected dose levels. Pharmacodynamic studies incorporated 18F-FDG-PET, and assessment of phosphorylated AKT and S6 ribosomal protein in platelet-rich plasma (PRP) and tumor tissue. Results: Pictilisib was well tolerated. The most common toxicities were grade 1–2 nausea, rash, and fatigue, whereas the DLT was grade 3 maculopapular rash (450 mg, 2 of 3 patients; 330 mg, 1 of 7 patients). The pharmacokinetic profile was dose-proportional and supported once-daily dosing. Levels of phosphorylated serine-473 AKT were suppressed >90% in PRP at 3 hours after dose at the MTD and in tumor at pictilisib doses associated with AUC >20 h·μmol/L. Significant increase in plasma insulin and glucose levels, and >25% decrease in 18F-FDG uptake by PET in 7 of 32 evaluable patients confirmed target modulation. A patient with V600E BRAF–mutant melanoma and another with platinum-refractory epithelial ovarian cancer exhibiting PTEN loss and PIK3CA amplification demonstrated partial response by RECIST and GCIG-CA125 criteria, respectively. Conclusion: Pictilisib was safely administered with a dose-proportional pharmacokinetic profile, on-target pharmacodynamic activity at dose levels ≥100 mg and signs of antitumor activity. The recommended phase II dose was continuous dosing at 330 mg once-daily. Clin Cancer Res; 21(1); 77–86. ©2014 AACR.
Primer on gadolinium chemistry

Gadolinium is widely known by all practitioners of magnetic resonance imaging (MRI) but few appreciate the basic solution chemistry of this trivalent lanthanide ion. Given the recent linkage between gadolinium contrast agents and nephrogenic systemic fibrosis, some basic chemistry of this ion must be more widely understood. This short primer on gadolinium chemistry is intended to provide the reader the background principles necessary to understand the basics of chelation chemistry, water hydration numbers, and the differences between thermodynamic stability and kinetic stability or inertness. We illustrate the fundamental importance of kinetic dissociation rates in determining gadolinium toxicity in vivo by presenting new data for a novel europium DOTA‐tetraamide complex that is relatively unstable thermodynamically yet extraordinarily inert kinetically and also quite nontoxic. This, plus other literature evidence, forms the basis of the fundamental axiom that it is the kinetic stability of a gadolinium complex, not its thermodynamic stability, that determines its in vivo toxicity. J. Magn. Reson. Imaging 2009;30:1240–1248. © 2009 Wiley‐Liss, Inc.
Antecedents and Consequences of Attitude toward the Ad: A Meta-analysis

A meta-analysis of pairwise relationships involving attitude toward the ad was conducted. Analyses of correlations across studies are first analyzed and reported. Because significant variance across studies was found, moderator analyses were conducted to account for interstudy variance. The results suggest a number of methodological variables that moderate the strengths of relationships found in studies of ad attitudes. Analyses were also conducted to assess the robustness of the dual-mediation path model of the effects of ad attitudes. Results indicate support for the model as well as a more important role for the indirect influence of ad attitudes on brand attitudes (via brand cognitions) than that found in previous model tests. Copyright 1992 by the University of Chicago.
Beefcake and Cheesecake: Insights for Advertisers

Abstract Theory suggests that for an ad with a sexy illustration, the interaction of the sex of the viewer with the sex of the povocatively clothed model will influence that viewer's responses to the ad. Previous research with sexy ads has supported such reasoning, but principally has used women as the sexy models. The authors examined the responses of men and women to cheesecake and beefcake (a sexy male model) and found some expected and some surprising effects. Women reported disproportionately negative attitudes toward cheesecake ads, as hypothesized, but men did not show a parallel response to beefcake. They did have higher recall scores for ads with a nonsexy female model than for cheesecake ads, as expected. Significant results in a direction opposite from that hypothesized showed that women had higher recognition scores for cheesecake than for beefcake ads.
Affectometer 2: A scale to measure current level of general happiness

Affectometer 2 is a 5-minute inventory of general happiness or sense of well-being based on measuring the balance of positive and negative feelings in recent experience. Since this scale is directly derived from its parent scale, Affectometer 1, psychometric findings on the longer scale are reported along with initial data on Affectometer 2. These results indicate high reliability, high validity, and slight contamination by current mood and social desirability. Among the findings of special interest are: (a) the independence of positive and negative affect proposed by Bradburn is not confirmed; (b) well-being is highly and inversely related to neuroticism, anxiety, depression and somatic complaints; (c) the relationship of well-being to depression is curvilinear; (d) well-being scores are determined more by short-term states than long-term traits; (e) well-being can be characterized by 10 “qualities of happiness”.
Marxian analysis and mental illness

Andrew Scull, a sociologist who appreciates the significance of historical data, has been a highly visible and active participant in the scholarly debating dealing with the mentally ill, psychiatry, and public policy. His new book, Social Disorderl Mental Disorder,1 brings together a number of his articles published during the past fifteen years. The collection illuminates his own analyses and frequent disagreements with those who do not share his views. Underlying Scull’s scholarship is his firm belief that sociology and history are but two sides of the same coin, distinguishable yet inseparable. ’A sensitivity to questions of evidence and inference must be combined with theoretical sophistication and vision. ’2 Too often historians have ignored theory and emphasized data in the mistaken belief that a narrative is self-explanatory (just as sociologists have emphasized theory and misunderstood the nature of adequate data). Only theory, grounded in data and utilizing a comparative framework, he insists, can help scholars avoid an approach that legitimates the present and obscures alternatives.
Some Comments and Suggestions Concerning Population Pharmacokinetic Modeling, Especially of Digoxin, and Its Relation to Clinical Therapy

Abstract: Population pharmacokinetic and dynamic modeling is often employed to analyze data of steady-state trough serum digoxin concentrations in the course of what is frequently regarded as routine therapeutic drug monitoring (TDM). Such a monitoring protocol is extremely uninformative. It permits only the estimation of a single parameter of a 1-compartment model, such as clearance. The use of D-optimal design strategies permits much more information to be obtained, employing models having a really meaningful structure. Strategies and protocols for routine TDM policies greatly need to be improved, incorporating these principles of optimal design. Software for population pharmacokinetic modeling has been dominated by NONMEM. However, because NONMEM is a parametric method, it must assume a shape for the model parameter distributions. If the assumption is not correct, the model will be in error, and the most likely results given the raw data will not be obtained. In addition, the likelihood as computed by NONMEM is only approximate, not exact. This impairs statistical consistency and reduces statistical efficiency and the resulting precision of model parameter estimates. Other parametric methods are superior, as they provide exact likelihoods. However, they still suffer from the constraints of assuming the shape of the model parameter distributions. Nonparametric methods are more flexible. One need not make any assumptions about the shape of the parameter distributions. Nonparametric methods also provide exact likelihoods and are statistically consistent, efficient, and precise. They also permit maximally precise dosage regimens to be developed for patients using multiple model dosage design, something parametric modeling methods cannot do. Laboratory assay errors are better described by the reciprocal of the assay variance of each measurement rather than by coefficient of variation. This is easy to do and permits more precise models to be made. This also permits estimation of assay error separately from the other sources of uncertainty in the clinical environment. This is most useful scientifically. Digoxin has at least 2-compartment behavior. Its pharmacologic and clinical effects correlate not with serum digoxin concentrations but with those in the peripheral nonserum compartment. Some illustrative clinical examples are discussed. It seems that digitalis therapy, guided by TDM and our 2 compartment models based on that of Reuning et al, can convert at least some patients with atrial fibrillation and flutter to regular sinus rhythm. Investigators have often used steady-state trough concentrations only to make a 1-compartment model and have sought only to predict future steady-state trough concentrations. Much more than this can be done, and clinical care can be much improved. Further work along these lines is greatly to be desired.
An outbreak of listeriosis suspected to have been caused by rainbow trout

An outbreak of listeriosis in Sweden, consisting of nine cases, was investigated by means of molecular typing of strains from patients and strains isolated from suspected foodstuffs, together with interviews of the patients. Listeria monocytogenes was isolated from six of the patients, and all isolates were of the same clonal type. This clonal type was also isolated from a "gravad" rainbow trout, made by producer Y, found in the refrigerator of one of the patients. Unopened packages obtained from producer Y were also found to contain the same clonal type of L. monocytogenes. Based on the interview results and the bacteriological typing, we suspect that at least six of the nine cases were caused by gravad or cold-smoked rainbow trout made by producer Y. To our knowledge, this is the first rainbow trout-borne outbreak of listeriosis ever reported.