Miracle-dz/UniFAR-FTUs huggingface dataset:
Unraveling ancestry, kinship, and violence in a Late Neolithic mass grave

Significance We sequenced the genomes of 15 skeletons from a 5,000-y-old mass grave in Poland associated with the Globular Amphora culture. All individuals had been brutally killed by blows to the head, but buried with great care. Genome-wide analyses demonstrate that this was a large extended family and that the people who buried them knew them well: mothers are buried with their children, and siblings next to each other. From a population genetic viewpoint, the individuals are clearly distinct from neighboring Corded Ware groups because of their lack of steppe-related ancestry. Although the reason for the massacre is unknown, it is possible that it was connected with the expansion of Corded Ware groups, which may have resulted in violent conflict. The third millennium BCE was a period of major cultural and demographic changes in Europe that signaled the beginning of the Bronze Age. People from the Pontic steppe expanded westward, leading to the formation of the Corded Ware complex and transforming the genetic landscape of Europe. At the time, the Globular Amphora culture (3300–2700 BCE) existed over large parts of Central and Eastern Europe, but little is known about their interaction with neighboring Corded Ware groups and steppe societies. Here we present a detailed study of a Late Neolithic mass grave from southern Poland belonging to the Globular Amphora culture and containing the remains of 15 men, women, and children, all killed by blows to the head. We sequenced their genomes to between 1.1- and 3.9-fold coverage and performed kinship analyses that demonstrate that the individuals belonged to a large extended family. The bodies had been carefully laid out according to kin relationships by someone who evidently knew the deceased. From a population genetic viewpoint, the people from Koszyce are clearly distinct from neighboring Corded Ware groups because of their lack of steppe-related ancestry. Although the reason for the massacre is unknown, it is possible that it was connected with the expansion of Corded Ware groups, which may have resulted in competition for resources and violent conflict. Together with the archaeological evidence, these analyses provide an unprecedented level of insight into the kinship structure and social behavior of a Late Neolithic community.
The interaction between carcinogenic hydrocarbons and serum lipoproteins.

It has been established that water-insoluble carcinogens and their metabolic products are trans- ported in the blood following their administration to animals (4). Set~l~i and Ermala found that hydrocarbons, when fed, enter the circulation by a route similar to that of dietary fats (9). These investigators observed fluorescence in chylomi- crons in lymph and serum obtained from animals after ingestion of 3,4-benzpyrene. It has been previously shown that hydrocarbons can be suspended or solubilized in vitro in human or animal serum. Andervont and Lorenz (1) have suspended 1,2,5,6,-dibenzanthraeene in serum by treatment of the latter with an ethereal solution of the hydrocarbon and subsequent evaporation of the solvent. Under these conditions, however, the low-density lipoproteins must have lost most of the neutral lipides and changed their composi- tion (3). Falk, Miller, and Kotin (6) demonstrated that human plasma will extract polycyclic hydro- carbons from soot. Wunderly and Pezold (1I) carried out electrophoresis of serum on paper pre- viously saturated with carcinogenic hydrocarbons and found that the compounds moved in associa- tion with albumin and a and fi globulins. Chalmers (5) has shown that benzpyrene and other hydro- carbons dissolved in serum in vitro are mainly associated with fi-lipoprotein. In a previous study (3) whole serum and isolated serum lipoproteins were found to combine in vitro with cholesterol and other sterols and steroids. Using a similar method we have incorporated several carcinogens into serum. Some studies on the nature and prop- erties of such solutions are reported in this paper. MATERIALS AND METHODS 2-Nitrofluorene-9-C 14 (2-NF), 1.6 X 10 -~ ~c/ nag; 3-aminofluorene-9-C 14 (2-AF), 7.3 X 10 -1 gc/ mg; and 2-acetylaminofluorene-9-C14 (2-AAF), 9.0 X 10 -1 #c/rag, were radiochemically pure, as es- tablished by paper chromatography with several
Care of general practice patients preceding and following a suicide attempt: observational study in Flemish general practices

Objectives First, to examine general practitioner (GP) knowledge about the care (needs) of their patients; second, to examine the quality of GP follow-up care; third, to examine the transmission of patient care information from hospitals/emergency services (ES) to GPs. Setting 105 general practices from the representative Belgian Network of Sentinel General Practices (SGP) in Flanders, the largest region of Belgium, during 2013–2016. Participants 245 suicide attempts by regular patients. Outcomes measures Ten care-related measures, including three indicators of quality of follow-up care, were based on data reported by the SGP on structured forms at baseline and at two follow-up points in time. Results As for GP knowledge, 10.5% of SGP failed to report whether suicidal risk was noticed in patients seen in the month preceding the attempt; 9.0% whether there were previous attempts; 22.5% whether the patient was receiving mental health treatment at follow-up and 22.0% whether suicidal behaviour was repeated at follow-up. Relatively more patients≥65 years had no suicide risk evaluation (OR 3.54; 95% CI 1.11 to 11.26). As for quality of follow-up care, there was a GP–patient contact following 90.5% of the attempts, follow-up appointments were planned following 43.4% of the attempts and there was a GP contact with patient proxies following 62.8% of the attempts. Patient age ≥65 years (OR 4.09; 95% CI 1.79 to 9.33), a recent GP–patient contact preceding the attempt (OR 1.97; 95% CI 1.13 to 3.43), depression of patient (OR 1.96; 95% CI 1.14 to 3.37) and a suburban SGP area (OR 2.34; 95% CI 1.13 to 4.82) were determinants of an increased quality of care sum. GPs received patient care information from a hospital (ES) for 67.8% of eligible attempts, with SGP practice location being a determinant. Conclusions GPs are highly involved in the care of suicide attempters but there is room for improvement, also in informational continuity from hospital (ES) to GPs.
Reconstruction of GABAergic Transmission and Behavior by Striatal Cell Grafts in Rats with Ischemic Infarcts in the Middle Cerebral Artery

Fetal striatal cell suspensions were grafted stereotaxically into the infarcted striatum of rats, and reconstruction of striatopallidal GABA transmission and behavior were investigated. Occlusion of the middle cerebral artery (MCA) for one hour induced ischemic infarcts mainly in the lateral striatum, as detected by magnetic resonance imaging (MRI) and histology. Ischemic rats had deficits in the performance of a passive avoidance task, both acquisition and retention, but no changes in general circadian actograms. In these animals pallidal GABA, detected by microdialysis, decreased to about half of control levels. There were suggestions of an improvement in passive avoidance performance in the grafted animals. Pallidal GABA concentrations recovered almost to control levels, and were increased by infusions of the GABA uptake blocker nipecotic acid. These data indicate that neural transplantation is a promising approach to improve the deficits in chemical transmission and behavior following ischemic infarcts in rat striatum.
The absence of vitreous inflammation: one more challenge in diagnosing toxoplasma papillitis

Toxoplasma is a leading cause of posterior uveitis in immunocompetent patients manifesting as a focal posterior retinochoroiditis. The clinical diagnosis of ocular toxoplasmosis is usually straightforward. There is typically a fluffy white retinal lesion which may lie adjacent to a pigmented chorioretinal scar and a prominent vitreous, or additionally, anterior chamber cellular reaction. Several unusual presentations in ocular toxoplasmosis have been reported, including: papillitis, neuroretinitis, retrobulbar neuritis, retinal detachment and macular oedema. This is a case of presumed primary toxoplasma papillitis in a 14-year-old child with complete absence of vitritis at presentation that made the diagnosis challenging. This evolved into neuroretinitis that resolved upon introducing antitoxoplasma antibiotics.
The Many Faces of Nonprofit Accountability

What does it mean for a nonprofit organization to be accountable? Nonprofit leaders tend to pay attention to accountability once a problem of trust arises – a scandal in the sector or in their own organization, questions from citizens or donors who want to know if their money is being well spent, or pressure from regulators to demonstrate that they are serving a public purpose and thus merit tax-exempt status. Amid this clamor for accountability, it is tempting to accept the popular view that more accountability is better. But is it feasible, or even desirable, for nonprofit organizations to be accountable to everyone for everything? The challenge for leadership and management is to prioritize among competing accountability demands. This involves deciding both to whom and for what they owe accountability. This paper provides an overview of the accountability pressures facing nonprofit leaders, and examines several mechanisms available to them: disclosures, performance evaluations, self-regulation, participation, and adaptive learning. Nonprofit leaders must adapt any such mechanisms to suit their organization — be it a membership-based organization, a service-delivery nonprofit, or an advocacy network. More crucially, they need to pay greater attention to strategy-driven forms of accountability that can help them to achieve their missions. 1 This paper is a preprint draft of a chapter accepted for publication in the Jossey-Bass Handbook of Nonprofit Leadership and Management (Third Edition, 2010). It is a much expanded and revised version of an entry that was first published in the International Encyclopedia of Civil Society (Ebrahim, 2010).
Rivers across the Siberian Arctic unearth the patterns of carbon release from thawing permafrost

Significance High-latitude permafrost and peat deposits contain a large reservoir of dormant carbon that, upon warming, may partly degrade to CO2 and CH4 at site and may partly enter rivers. Given the scale and heterogeneity of the Siberian Arctic, continent-wide patterns of thaw and remobilization have been challenging to constrain. This study combines a decade-long observational record of 14C in organic carbon of four large Siberian rivers with an extensive 14C source fingerprint database into a statistical model to provide a quantitative partitioning of the fraction of fluvially mobilized organic carbon that specifically stems from permafrost and peat deposits, and separately for dissolved and particulate vectors, across the Siberian Arctic, revealing distinct spatial and seasonal system patterns in carbon remobilization. Climate warming is expected to mobilize northern permafrost and peat organic carbon (PP-C), yet magnitudes and system specifics of even current releases are poorly constrained. While part of the PP-C will degrade at point of thaw to CO2 and CH4 to directly amplify global warming, another part will enter the fluvial network, potentially providing a window to observe large-scale PP-C remobilization patterns. Here, we employ a decade-long, high-temporal resolution record of 14C in dissolved and particulate organic carbon (DOC and POC, respectively) to deconvolute PP-C release in the large drainage basins of rivers across Siberia: Ob, Yenisey, Lena, and Kolyma. The 14C-constrained estimate of export specifically from PP-C corresponds to only 17 ± 8% of total fluvial organic carbon and serves as a benchmark for monitoring changes to fluvial PP-C remobilization in a warming Arctic. Whereas DOC was dominated by recent organic carbon and poorly traced PP-C (12 ± 8%), POC carried a much stronger signature of PP-C (63 ± 10%) and represents the best window to detect spatial and temporal dynamics of PP-C release. Distinct seasonal patterns suggest that while DOC primarily stems from gradual leaching of surface soils, POC reflects abrupt collapse of deeper deposits. Higher dissolved PP-C export by Ob and Yenisey aligns with discontinuous permafrost that facilitates leaching, whereas higher particulate PP-C export by Lena and Kolyma likely echoes the thermokarst-induced collapse of Pleistocene deposits. Quantitative 14C-based fingerprinting of fluvial organic carbon thus provides an opportunity to elucidate large-scale dynamics of PP-C remobilization in response to Arctic warming.
Healthy User Bias in Comparative Safety Studies for Brand‐Name vs. Generic Products: The Example of Warfarin

Warfarin was selected as a case study to examine confounding when comparing a product across different manufacturers because it is a narrow therapeutic index drug with prevalent beliefs for brand‐name superiority. Medicare beneficiaries aged ≥65 years with atrial fibrillation and an incident outpatient warfarin prescription from July 2006 through July 2015 were included in the study population (N = 746,098). Substantial imbalances were observed between brand‐name warfarin and generics for (i) clinical comorbidity, (ii) socioeconomic status, (iii) prescriber specialty, (iv) recent ambulatory and emergent care, (v) drug adherence, (vi) pharmacy setting (e.g., retail, mail‐order), and (vii) risk scores for bleeding and thrombosis. Patients receiving brand‐name warfarin were healthier than patients receiving generic manufactured warfarin. Utilization of generic warfarin products also differed by geographic region and pharmacy setting. Manufacturer‐level comparative‐safety studies for causal inference should carefully consider the presence of these imbalances and their potential for introducing healthy user bias.
A comparison of antagonism of rocuronium‐induced neuromuscular blockade during sevoflurane and isoflurane anaesthesia

Volatile anaesthetic agents potentiate neuromuscular blocking agents and retard their rate of reversal. We hypothesised that there was a difference in the rate of reversal of rocuronium‐induced neuromuscular blockade based on the selection of inhalation agent. Thirty‐eight patients undergoing elective surgical procedures received either sevoflurane or isoflurane, by random allocation. Neuromuscular blockade was induced using rocuronium 0.6 mg.kg−1 followed by continuous intravenous infusion to maintain 90% suppression of the single twitch response. Upon completion of surgery, the rocuronium infusion was discontinued, neostigmine 50 µg. kg−1 and glycopyrrolate 10 µg. kg−1 were administered. Times from reversal to T1 = 25, 50 and 60% and train‐of‐four ratio = 0.6 were recorded. The mean (SD) times to train‐of‐four ratio = 0.6 in the isoflurane and sevoflurane groups were 327 (132) and 351 (127) s, respectively. The mean (SD) times to single twitch response T1 = 25, 50 and 60% in the isoflurane group were 81 (33), 161 (59) and 245 (84) s, respectively, and in the sevoflurane group were 95 (35), 203 (88) and 252 (127) s, respectively. It is concluded that reversal of rocuronium‐induced neuromuscular blockade is similar during isoflurane and sevoflurane anaesthesia.
Engagement and experience of older people with socially assistive robots in home care

ABSTRACT Social isolation is one of the most common consequences of older people with dementia, especially for those who live at their own dwellings alone due to limited access to social activities. Research relating to the use of social robots in aged care has increasing attention to facilitating the support to care services for older people with dementia. Particularly less attention has focused on the applicability of social robots in home care services. This paper aims to study the engagement and robot experience of older people with dementia while interacting with a social robot named Betty in the context of home-based care. This paper contributes to the research relating to care service embedded robots by expanding the knowledge regarding longitudinal research in home based care, while there is limited long-term study in this context. The results show that social robots are evident to be able to engage with older people with dementia at home. Consequently, designing social robots in a social context is desirable. While the robots enabled service for the human partner within the social context is possible, there is a need to underpin the concept of personhood to realize personalization of services and its contents to suit individual preferences.
Lagrange Stability and Finite-Time Stabilization of Fuzzy Memristive Neural Networks With Hybrid Time-Varying Delays

This paper focuses on Lagrange exponential stability and finite-time stabilization of Takagi–Sugeno (T–S) fuzzy memristive neural networks with discrete and distributed time-varying delays (DFMNNs). By resorting to theories of differential inclusions and the comparison strategy, an algebraic condition is developed to confirm Lagrange exponential stability of the underlying DFMNNs in Filippov’s sense, and the exponentially attractive set is estimated. When external input is not considered, global exponential stability of DFMNNs is derived directly, which includes some existing ones as special cases. Furthermore, finite-time stabilization of the addressed DFMNNs is analyzed by exploiting inequality techniques and the comparison approach via designing a nonlinear state feedback controller. The boundedness assumption of activation functions is removed herein. Finally, two simulations are presented to demonstrate the validness of the outcomes, and an application is performed in pseudorandom number generation.
GDNF‐ADSCs‐APG embedding enhances sciatic nerve regeneration after electrical injury in a rat model

The pluripotency of adipose‐derived stem cells (ADSCs) makes them appropriate for tissue repair and wound healing. Owing to the repair properties of autologous platelet–rich gel (APG), which is based on easily accessible blood platelets, its clinical use has been increasingly recognized by physicians. The aim of this study was to investigate the effect of combined treatment with ADSCs and APG on sciatic nerve regeneration after electrical injury. To facilitate the differentiation of ADSCs, glial cell line–derived neurotrophic factor (GDNF) was overexpressed in ADSCs by lentivirus transfection. GDNF‐ADSCs were mingled with APG gradient concentrations, and in vitro, cell proliferation and differentiation were examined with 5‐ethynyl‐2′‐deoxyuridine staining and immunofluorescence. A rat model was established by exposing the sciatic nerve to an electrical current of 220 V for 3 seconds. Rat hind‐limb motor function and sciatic nerve regeneration were subsequently evaluated. Rat ADSCs were characterized by high expression of CD90 and CD105, with scant expression of CD34 and CD45. We found that GDNF protein expression in ADSCs was elevated after Lenti‐GDNF transfection. In GDNF‐ADSCs‐APG cultures, GDNF was increasingly produced while tissue growth factor‐β was reduced as incubation time was increased. ADSC proliferation was augmented and neuronal nuclei (NeuN) and glial fibrillary acidic protein (GFAP) expression were upregulated in GDNF‐ADSCs‐APG. In addition, limb motor function and nerve axon growth were improved after GDNF‐ADSCs‐APG treatment. In conclusion, our study demonstrates the combined effect of ADSCs and APG in peripheral nerve regeneration and may lead to treatments that benefit patients with electrical injuries.
Validity Evidence of the Retirement Resources Inventory

Abstract The current populational aging context requires that society reflect on the variables related with well-being and discuss ways of how to ensure them. The Conservation of Resources Theory (Hobfoll, 1989, 2002) posits that individuals who possess more material or social resources are more capable of resolving conflicts and dealing with stressful situations, thus maintaining good levels of well-being. However, there is a lack of instruments aimed at measuring the necessary resources for retirement well-being. The objective of this study was to translate and analyse the psychometric qualities of the Retirement Resources Inventory (RRI) (Leung & Earl, 2012) as applied to 1002 Brazilian retirees. Exploratory and confirmatory factor analysis were undertaken using two independent subsamples consisting of 401 and 601 retirees respectively. Two viable models arose from the exploratory analysis: A five-factor model, χ2(gl) = 816.644 (271); CFI = 0.88; GFI = 0.98; RMSEA = 0.07; R2 = 0.55; and a six-factor model, χ2(gl) = 1028.291 (400); CFI = 0.88; GFI = 0.98; RMSEA = 0.03; R2= 0.53, with good fit indices, but similar to each other. Confirmatory analysis pointed towards an instrument consisting of 29 items and five factors with good fit indices, χ2(gl) = 1,274(364); CFI = 0.87; TLI: 0.86; RMSEA: 0.06, corroborating the model proposed by Wang and Shultz (2010). The analyses also highlighted the need for actions that take into account the gender, age and region of the country where the retiree lives. Future cross-cultural studies are recommended seeing that retirement planning is an emerging issue that affects the world as a whole.
Ankle-Brachial Index is a Predictor of Future Incident Chronic Kidney Disease in a General Japanese Population

Aims: The ankle-brachial index (ABI) can be a prognostic marker for chronic kidney disease (CKD) in Western populations. Since there is little relevant evidence for Asian populations, we investigated the relationship between ABI and the risk of incident CKD in a general Japanese population. Methods: The cohort included 5,072 participants aged 30–79 without a history of renal disease or cerebro-cardiovascular disease. Incident CKD, defined as an estimated glomerular filtration rate < 60 (mL/min/1.73 m2) and/or proteinuria (≥ 1 + on urine dipstick), was compared among participants grouped according to baseline ABI: 0.90–0.99, 1.00–1.09, 1.10–1.19, 1.20–1.29, and 1.30–1.39. Hazard ratios for incident CKD were estimated using a Cox proportional hazards model, with the ABI 1.10–1.19 group serving as the reference. Results: The CKD incidence rate (/100 person-years) was 1.80 during the mean follow-up period of 5.1 years. The CKD incidence rate was 3.04 in the ABI category 0.90–0.99, 1.58 in ABI 1.00–1.09, 1.72 in ABI 1.10–1.19, 2.01 in ABI 1.20–1.29, and 3.33 in ABI 1.30–1.39. The hazard ratios for developing CKD were 2.14 (95% confidence interval 1.16–3.92) in ABI 0.90–0.99, 1.08 (0.83–1.41) in ABI 1.00–1.09, 1.03 (0.83–1.29) in ABI 1.20–1.29, and 1.37 (0.77–2.47) in ABI 1.30–1.39, after adjusting for age, sex, systolic blood pressure, diabetes, and other confounding factors. Conclusions: In a general Japanese population, an ABI of 0.90–0.99 was associated with an increased risk of incident CKD, independent of traditional cardiovascular risk factors.