Miracle-dz/UniFAR-FTUs huggingface dataset:
Attempts to reduce alcohol intake and treatment needs among people with probable alcohol dependence in England: a general population survey

AIMS To compare the proportion of people in England with probable alcohol dependence [Alcohol Use Disorders Identification Test (AUDIT) score ≥ 20] with those with other drinking patterns (categorized by AUDIT scores) in terms of motivation to reduce drinking and use of alcohol support resources. DESIGN A combination of random probability and simple quota sampling to conduct monthly cross-sectional household computer-assisted interviews between March 2014 and August 2017. SETTING The general population in all nine regions of England. PARTICIPANTS Participants in the Alcohol Toolkit Study (ATS), a monthly household survey of alcohol consumption among people aged 16 years and over in England (n = 69 826). The mean age was 47 years [standard deviation (SD) = 18.78; 95% confidence interval (CI) = 46.8-47] and 51% (n = 35 560) were female. MEASUREMENTS χ2 tests were used to investigate associations with demographic variables, motivation to quit drinking, attempts to quit drinking, general practitioner (GP) engagement and types of support accessed in the last 12 months across AUDIT risk zones. FINDINGS A total of 0.6% were classified as people with probable alcohol dependence (95% CI = 0.5-0.7). Motivation to quit (χ2 = 1692.27, P < 0.001), current attempts (χ2 = 473.94, P < 0.001) and past-year attempts (χ2 = 593.67, P < 0.001) differed by AUDIT risk zone. People with probable dependence were more likely than other ATS participants to have a past-year attempt to cut down or quit (51.8%) and have received a specialist referral from their GP about drinking (13.7%), and less likely to report no motivation to reduce their drinking (26.2%). Those with probable dependence had higher use of self-help books and mobile applications (apps) than other ATS participants; however, 27.7% did not access any resources during their most recent attempt to cut down. CONCLUSIONS Adults in England with probable alcohol dependence, measured through the Alcohol Use Disorders Identification Test, demonstrate higher motivation to quit drinking and greater use of both specialist treatment and self-driven support compared with those in other Alcohol Use Disorders Identification Test zones, but most do not access treatment resources to support their attempts.
Seismic Retrofit of RC Columns with Continuous Carbon Fiber Jackets

The development, the validation, and the implementation of a new seismic retrofit system for reinforced concrete columns are described. The column jacketing system consists of continuous carbon fiber prepreg tows wound in an automated fashion onto existing circular or rectangular concrete columns, with variable jacket thickness along the column height based on experimentally validated design models. Jacket design criteria for various seismic column failure modes are described and detailed examples show their application to retrofits of columns with circular and rectangular column geometry, different reinforcement ratios, and detailing. The carbon jacket designs are validated through large-scale bridge column model tests and are found to be just as effective as steel shell jacketing in providing desired inelastic design deformation capacity levels. Furthermore, it is shown that the retrofit criteria and guidelines are also applicable to other advanced composite jacketing systems with appropriate considerat.
Genetic Polymorphism of Leptin Gene in Relation with Reproduction Traits in Hariana Cows

Leptin gene is considered as marker of production and reproduction traits in dairy or beef cattle. The aim of this study was to investigate the genetic polymorphism in LEP gene in Hariana cows and their associations with reproduction traits. The blood samples were collected from 62 Hariana cows and analyzed in order to identify LEP/BsaAI (BTA 4, intron 2 and exon 3) genotypes using PCR-RFLP method. The allele frequencies observed were 0.37 and 0.63 for A and B LEP variants and genotypic frequencies were 9.67, 54.8 and 35.5 for AA, AB and BB genotype variants, respectively. Statistical analysis showed that SNP LEP/BsaAI significantly affected gestation period and dry period in analyzed population of cows. Observations of this investigation advocated that leptin is a candidate gene, which affects reproduction traits and might be implemented in breeding strategies to improve the reproductive performance of Hariana cattle breed.
In vivo high-resolution cortical imaging with extended-focus optical coherence microscopy in the visible-NIR wavelength range

Abstract. Visible light optical coherence tomography has shown great interest in recent years for spectroscopic and high-resolution retinal and cerebral imaging. Here, we present an extended-focus optical coherence microscopy system operating from the visible to the near-infrared wavelength range for high axial and lateral resolution imaging of cortical structures in vivo. The system exploits an ultrabroad illumination spectrum centered in the visible wavelength range (λc = 650 nm, Δλ ∼ 250 nm) offering a submicron axial resolution (∼0.85 μm in water) and an extended-focus configuration providing a high lateral resolution of ∼1.4 μm maintained over ∼150 μm in depth in water. The system’s axial and lateral resolution are first characterized using phantoms, and its imaging performance is then demonstrated by imaging the vasculature, myelinated axons, and neuronal cells in the first layers of the somatosensory cortex of mice in vivo.
Prognostic evaluation by oxygenation with positive end‐expiratory pressure in acute exacerbation of idiopathic pulmonary fibrosis: A retrospective cohort study

Acute exacerbation (AE) is a severe complication of idiopathic pulmonary fibrosis (IPF), which shares some common pathological features with acute respiratory distress syndrome (ARDS). The new definition of ARDS requires positive end‐expiratory pressure (PEEP) to assess gas exchange and has better predictive validity for short‐term mortality compared with the previous definition.
Distribution of IFITM3 polymorphism (dbSNP: rs12252) in mestizo populations in four states of Mexico

Interferon‐inducible transmembrane protein 3 (IFITM3) participates in the defense against viral infections. This study identified and compared the frequency of the IFITM3 rs12252 polymorphism in 410 individuals in western Mexico. The western Mexican allelic frequencies (frequency of the “C” allele = 0.18) differ from some American, East Asian and European populations.
The joint evolution of the Myxozoa and their alternate hosts: A cnidarian recipe for success and vast biodiversity

The relationships between parasites and their hosts are intimate, dynamic and complex; the evolution of one is inevitably linked to the other. Despite multiple origins of parasitism in the Cnidaria, only parasites belonging to the Myxozoa are characterized by a complex life cycle, alternating between fish and invertebrate hosts, as well as by high species diversity. This inspired us to examine the history of adaptive radiations in myxozoans and their hosts by determining the degree of congruence between their phylogenies and by timing the emergence of myxozoan lineages in relation to their hosts. Recent genomic analyses suggested a common origin of Polypodium hydriforme, a cnidarian parasite of acipenseriform fishes, and the Myxozoa, and proposed fish as original hosts for both sister lineages. We demonstrate that the Myxozoa emerged long before fish populated Earth and that phylogenetic congruence with their invertebrate hosts is evident down to the most basal branches of the tree, indicating bryozoans and annelids as original hosts and challenging previous evolutionary hypotheses. We provide evidence that, following invertebrate invasion, fish hosts were acquired multiple times, leading to parallel cospeciation patterns in all major phylogenetic lineages. We identify the acquisition of vertebrate hosts that facilitate alternative transmission and dispersion strategies as reason for the distinct success of the Myxozoa, and identify massive host specification‐linked parasite diversification events. The results of this study transform our understanding of the origins and evolution of parasitism in the most basal metazoan parasites known.
Brain systems for assessing the affective value of faces

Cognitive neuroscience research on facial expression recognition and face evaluation has proliferated over the past 15 years. Nevertheless, large questions remain unanswered. In this overview, we discuss the current understanding in the field, and describe what is known and what remains unknown. In §2, we describe three types of behavioural evidence that the perception of traits in neutral faces is related to the perception of facial expressions, and may rely on the same mechanisms. In §3, we discuss cortical systems for the perception of facial expressions, and argue for a partial segregation of function in the superior temporal sulcus and the fusiform gyrus. In §4, we describe the current understanding of how the brain responds to emotionally neutral faces. To resolve some of the inconsistencies in the literature, we perform a large group analysis across three different studies, and argue that one parsimonious explanation of prior findings is that faces are coded in terms of their typicality. In §5, we discuss how these two lines of research—perception of emotional expressions and face evaluation—could be integrated into a common, cognitive neuroscience framework.
TOAST

Touch typing on flat surfaces (e.g. interactive tabletop) is challenging due to lack of tactile feedback and hand drifting. In this paper, we present TOAST, an eyes-free keyboard technique for enabling efficient touch typing on touch-sensitive surfaces. We first formalized the problem of keyboard parameter (e.g. location and size) estimation based on users' typing data. Through a user study, we then examined users' eyes-free touch typing behavior on an interactive tabletop with only asterisk feedback. We fitted the keyboard model to the typing data, results suggested that the model parameters (keyboard location and size) changed not only between different users, but also within the same user along with time. Based on the results, we proposed a Markov-Bayesian algorithm for input prediction, which considers the relative location between successive touch points within each hand respectively. Simulation results showed that based on the pooled data from all users, this model improved the top-1 accuracy of the classical statistical decoding algorithm from 86.2% to 92.1%. In a second user study, we further improved TOAST with dynamical model parameter adaptation, and evaluated users' text entry performance with TOAST using realistic text entry tasks. Participants reached a pick-up speed of 41.4 WPM with a character-level error rate of 0.6%. And with less than 10 minutes of practice, they reached 44.6 WPM without sacrificing accuracy. Participants' subjective feedback also indicated that TOAST offered a natural and efficient typing experience.
An Open Architecture for Transfer-based Machine Translation between Spanish and Basque

We present the current status of development of an open architecture for the translation from Spanish into Basque. The machine translation architecture uses an open source analyser for Spanish and new modules mainly based on finite-state transducers. The project is integrated in the OpenTrad initiative, a larger government funded project shared among different universities and small companies, which will also include MT engines for translation among the main languages in Spain. The main objective is the construction of an open, reusable and interoperable framework. This paper describes the design of the engine, the formats it uses for the communication among the modules, the modules reused from other project named Matxin and the new modules we are building.
Facial Expression Recognition Based On Hierarchical Feature Learning

Facial expression recognition is a challenging problem in the field of computer vision. In this paper, we propose a deep learning approach that can learn the joint low-level and high-level features of human face to resolve this problem. Our deep neural networks utilize convolution and downsampling to extract the abstract and local features of human face, and reconstruct the raw input images to learn global features as supplementary information at the same time. We also add an adjustable weight in the networks when combining the two kinds of features for the final classification. The experimental results show that the proposed method can achieve good results, which has an average recognition accuracy of 93.65% on the test datasets.
Public strategies for improving eHealth integration and long‐term sustainability in public health care systems: Findings from an Italian case study

Summary eHealth is expected to contribute in tackling challenges for health care systems. However, it also imposes challenges. Financing strategies adopted at national as well regional levels widely affect eHealth long‐term sustainability. In a public health care system, the public actor is among the main “buyers” eHealth. However, public interventions have been increasingly focused on cost containment. How to match these 2 aspects? This article explores some central issues, mainly related to financial aspects, in the development of effective and valuable eHealth strategies in a public health care system: How can the public health care system (as a “buyer”) improve long‐term success and sustainability of eHealth solutions? What levers are available to match in the long period different interests of different stakeholders in the eHealth field? A case study was performed in the Region of Tuscany, Italy. According to our results, win‐win strategies should be followed. Investments should take into account the need to long‐term finance solutions, for sustaining changes in health care organizations for obtaining benefits. To solve the interoperability issues, the concept of the “platform approach” emerged, based on collaboration within and between organizations. Private sector as well as beneficiaries and final users of the eHealth solutions should participate in their design, provision, and monitoring. For creating value for all, the evidence gap and the financial needs could be addressed with a pull mechanism of funding, aimed at paying according to the outcomes produced by the eHealth solution, on the base of an ongoing monitoring, measurement, and evaluation of the outcomes.
A Comparison between the EQ-5D and the SF-6D in Patients with Chronic Obstructive Pulmonary Disease (COPD)

Background The appropriate use of generic preference-based measures determines the accuracy of disease assessment and further decision on healthcare policy using quality adjusted life years. The discriminative capacity of different instruments would differ across disease groups. Our study was to examine the difference in utility scores for COPD patients measured by EQ-5D and SF-6D and to assist the choice of a proper instrument in this disease group. Methods Differences of mean utility scores of EQ-5D and SF-6D in groups defined by socio-demographic characteristics, comorbidities, health service utilisation and severity of illness were tested using Mann-Whitney test, t-test, Kruskal-Wallis test, Pearson’s correlation coefficient and ANOVA, as appropriate. The discriminative properties of the two instruments were compared against indicators of quality of life using receiver operating characteristic curves. The statistical significance of the area under the curves (AUC) was tested by ANOVA and F-statistics used to compare the efficiency with which each instrument discriminated between disease severity groups. Results Mean utility scores of EQ-5D and SF-6D were 0.644 and 0.629 respectively in the 154 subjects included in the analysis. EQ-5D scores were significantly higher than SF-6D in groups less severe and these differences corresponded to a minimally important difference of greater than 0.03 (p<0.001). EQ-5D and SF-6D scores were strongly correlated across the whole sample (r = 0.677, p<0.001) and in pre-defined groups (r>0.5 and p<0.05 for all correlation coefficients). AUCs were above 0.5 against the indicators of health-related quality of life for both instruments. F-ratios suggested SF-6D was more efficient in discriminating cases of different disease severity than EQ-5D. Conclusions Both EQ-5D and SF-6D appeared to be valid preference-based measures in Chinese COPD patients. SF-6D was more efficient in detecting differences among subgroups with differing health status. EQ-5D and SF-6D measured different things and might not be used interchangeably in COPD patients.
The Child-care Food and Activity Practices Questionnaire (CFAPQ): development and first validation steps

Abstract Objective To develop and validate a questionnaire to measure food-related and activity-related practices of child-care staff, based on existing, validated parenting practices questionnaires. Design A selection of items from the Comprehensive Feeding Practices Questionnaire (CFPQ) and the Preschooler Physical Activity Parenting Practices (PPAPP) questionnaire was made to include items most suitable for the child-care setting. The converted questionnaire was pre-tested among child-care staff during cognitive interviews and pilot-tested among a larger sample of child-care staff. Factor analyses with Varimax rotation and internal consistencies were used to examine the scales. Spearman correlations, t tests and ANOVA were used to examine associations between the scales and staff’s background characteristics (e.g. years of experience, gender). Setting Child-care centres in the Netherlands. Subjects The qualitative pre-test included ten child-care staff members. The quantitative pilot test included 178 child-care staff members. Results The new questionnaire, the Child-care Food and Activity Practices Questionnaire (CFAPQ), consists of sixty-three items (forty food-related and twenty-three activity-related items), divided over twelve scales (seven food-related and five activity-related scales). The CFAPQ scales are to a large extent similar to the original CFPQ and PPAPP scales. The CFAPQ scales show sufficient internal consistency with Cronbach’s α ranging between 0·53 and 0·96, and average corrected item–total correlations within acceptable ranges (0·30–0·89). Several of the scales were significantly associated with child-care staff’s background characteristics. Conclusions Scale psychometrics of the CFAPQ indicate it is a valid questionnaire that assesses child-care staff’s practices related to both food and activities.
Neurological Soft Signs and Psychopathology in Chronic Schizophrenia: A Cross-Sectional Study in Three Age Groups

As established in a wealth of studies subtle motor and sensory neurological abnormalities or neurological soft signs (NSS) are frequently found in patients with schizophrenia at any stage of their illness. However, the potential impact of chronicity and age on NSS was scarcely investigated. Therefore, we assessed NSS in 90 patients with subchronic (n = 22) or chronic (n = 68) schizophrenia and in 60 healthy controls who were assigned to three age groups (18–29, 30–49, and +50 years). NSS were measured on the Heidelberg Scale, psychopathological symptoms including apathy were rated on established instruments. As demonstrated by analysis of variance, NSS scores in patients were significantly (p < 0.05) increased relative to healthy controls. Significant age effects arose in all NSS subscores, with older subjects scoring well above the younger ones. These age effects were more pronounced in patients than controls, indicating that NSS in chronic schizophrenia exceed age-associated changes. Moreover, the NSS scores in patients were significantly associated with duration of illness, thought disturbance, positive symptoms, and apathy. These results were confirmed after age/duration of illness and years of education were partialed out and via regression analyses. Our findings conform to the hypothesis that NSS are associated with chronicity of the disorder as indicated by the correlations of NSS with both, duration of illness and apathy. The correlations between NSS and positive symptoms/thought disturbance correspond to the fluctuation of positive symptoms during the course of the disorder. The significantly more pronounced age effects on NSS in patients may either point to ongoing cerebral changes or to a greater susceptibility of patients toward physiological age effects, which may be mediated among other factors by a lower cognitive reserve.
Rehabilitation as “destination triage”: a critical examination of discharge planning

Abstract Purpose: In this paper we examine how the intersection of various social and political influences shapes discharge planning and rehabilitation practices in ways that may not meet the espoused aims of rehabilitation programs or the preferences of older adults and their families. Methods: Taking a critical bioethics perspective, we used microethnographic case study methods to examine discharge-planning processes in a well-established older adult inpatient rehabilitation setting in Canada. The data included observations of discharge-planning family conferences and semi-structured interviews conducted with older adults facing discharge, their family members and rehabilitation professionals involved in discharge planning. Results: From the time of admission, a contextual push to focus on discharge superseded program aims of providing interventions to increase older adults’ functional capabilities. Professionals’ primary commitment to safety limited consideration of discharge options and resulted in costly and potentially unnecessary recommendations for 24-hour care. The resulting “rehabilitation” stay was more akin to an extended process of “destination triage” biased towards the promotion of physical safety than optimizing functioning. Conclusions: The resulting reduction of rehabilitation into “destination triage” has significant social, financial and occupational implications for older adults and their families, and broader implications for healthcare services and overarching healthcare systems. Implications for Rehabilitation Current trends promoting consideration of discharge planning from the point of admission and prioritizing physical safety are shifting the focus of rehabilitation away from interventions to maximize recovery of function, which are the stated aims of rehabilitation. Such practices furthermore promote assessments to determine prognosis early in the rehabilitation stay when accurate prognosis is difficult, which can lead to overly conservative recommendations for discharge from rehabilitation services, thus further negating the impact of rehabilitation. Further work is required to examine the social, occupational and functional implications of superseding rehabilitation interventions to maximize capabilities with practices that prioritize safety over quality of life for older adults and their family members.