Miracle-dz/UniFAR-FTUs huggingface dataset:
R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study.

PURPOSE The type 1 insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the pathogenesis of the Ewing sarcoma family of tumors (ESFT). We conducted a multicenter phase II study of the fully human IGF-1R monoclonal antibody R1507 in patients with recurrent or refractory ESFT. PATIENTS AND METHODS Patients ≥ 2 years of age with refractory or recurrent ESFT received R1507 at doses of 9 mg/kg intravenously one a week or 27 mg/kg intravenously every three weeks. Response was measured by using WHO criteria. Tumor imaging was performed every 6 weeks for 24 weeks and then every 12 weeks. RESULTS From December 2007 through April 2010, 115 eligible patients from 31 different institutions were enrolled. The median age was 25 years (range, 8 to 78 years). The location of the primary tumor was bone in 57% of patients and extraskeletal in 43% of patients. A total of 109 patients were treated with R1507 9 mg/kg/wk, and six patients were treated with 27 mg/kg/3 wk. The overall complete response/partial response rate was 10% (95% CI, 4.9% to 16.5%). The median duration of response was 29 weeks (range, 12 to 94 weeks), and the median overall survival was 7.6 months (95% CI, 6 to 9.7 months). Ten of 11 responses were observed in patients who presented with primary bone tumors (P = .016). The most common adverse events of grades 3 to 4 were pain (15%), anemia (8%), thrombocytopenia (7%), and asthenia (5%). CONCLUSION R1507 was a well-tolerated agent that had meaningful and durable benefit in a subgroup of patients with ESFT. The identification of markers that are predictive of a benefit is necessary to fully capitalize on this approach.
A Study of Index Structures for a Main Memory Database Management System

One approach to achieving high performance in a database management system is to store the database in main memorv rather than on disk. -One can then design new data structures aid algorithms oriented towards making eflicient use of CPU cycles and memory space rather than minimizing disk accesses and &ing disk space efliciently. In this paper we present some results on index structures from an ongoing study of main memory database management systems. We propose a new index structure, the T Tree, and we compare it to existing index structures in a main memory database environment. Our results indicate that the T Tree provides good overall performance in main memory.
The impact of adventure video games on foreign language learning and the perceptions of learners

Several researchers have highlighted the potential of applying adventure video games in second language acquisition; however, few studies have investigated the impact of adventure games on foreign language learning. This study aimed to examine the effects of a commercial adventure video game on foreign language learning and learners’ perceptions toward this game. Twenty-two college students in Taiwan were asked to play an English adventure game BONE. One group was allowed to take notes while playing and the other group was not. After playing, both groups were asked to take a vocabulary post-test. The results indicated that both groups picked up some new words after playing the adventure game, but there was no significant difference between the two groups’ post-gaming performances. To better understand the strengths and weaknesses of using adventure games for foreign language learning, another study was conducted to explore 35 college students’ perceptions toward this adventure game. The results showed that students considered the game helpful in improving their language skills and motivation. Students also reported they enjoyed playing the game because of the intriguing game design. The findings in this study suggest that adventure video games such as BONE can provide useful input to help college students enhance their English listening, reading, vocabulary skills and learning motivation.
Plastid Proteomic Analysis in Tomato Fruit Development

To better understand the mechanism of plastid differentiation from chloroplast to chromoplast, we examined proteome and plastid changes over four distinct developmental stages of ‘Micro-Tom’ fruit. Additionally, to discover more about the relationship between fruit color and plastid differentiation, we also analyzed and compared ‘Micro-Tom’ results with those from two other varieties, ‘Black’ and ‘White Beauty’. We confirmed that proteins related to photosynthesis remain through the orange maturity stage of ‘Micro-Tom’, and also learned that thylakoids no longer exist at this stage. These results suggest that at a minimum there are changes in plastid morphology occurring before all related proteins change. We also compared ‘Micro-Tom’ fruits with ‘Black’ and ‘White Beauty’ using two-dimensional gel electrophoresis. We found a decrease of CHRC (plastid-lipid-associated protein) and HrBP1 (harpin binding protein-1) in the ‘Black’ and ‘White Beauty’ varieties. CHRC is involved in carotenoid accumulation and stabilization. HrBP1 in Arabidopsis has a sequence similar to proteins in the PAP/fibrillin family. These proteins have characteristics and functions similar to lipocalin, an example of which is the transport of hydrophobic molecules. We detected spots of TIL (temperature-induced lipocalin) in 2D-PAGE results, however the number of spots and their isoelectric points differed between ‘Micro-Tom’ and ‘Black’/‘White Beauty’. Lipocalin has various functions including those related to environmental stress response, apoptosis induction, membrane formation and fixation, regulation of immune response, cell growth, and metabolism adjustment. Lipocalin related proteins such as TIL and HrBP1 could be related to the accumulation of carotenoids, fruit color and the differentiation of chromoplast.
Comparative Analysis of Fruit Metabolites and Pungency Candidate Genes Expression between Bhut Jolokia and Other Capsicum Species

Bhut jolokia, commonly known as Ghost chili, a native Capsicum species found in North East India was recorded as the naturally occurring hottest chili in the world by the Guinness Book of World Records in 2006. Although few studies have reported variation in pungency content of this particular species, no study till date has reported detailed expression analysis of candidate genes involved in capsaicinoids (pungency) biosynthesis pathway and other fruit metabolites. Therefore, the present study was designed to evaluate the diversity of fruit morphology, fruiting habit, capsaicinoids and other metabolite contents in 136 different genotypes mainly collected from North East India. Significant intra and inter-specific variations for fruit morphological traits, fruiting habits and 65 fruit metabolites were observed in the collected Capsicum germplasm belonging to three Capsicum species i.e., Capsicum chinense (Bhut jolokia, 63 accessions), C. frutescens (17 accessions) and C. annuum (56 accessions). The pungency level, measured in Scoville Heat Unit (SHU) and antioxidant activity measured by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay showed maximum levels in C. chinense accessions followed by C. frutescens accessions, while C. annuum accessions showed the lowest value for both the traits. The number of different fruit metabolites detected did not vary significantly among the different species but the metabolite such as benzoic acid hydroxyl esters identified in large percentage in majority of C. annuum genotypes was totally absent in the C. chinense genotypes and sparingly present in few genotypes of C. frutescens. Significant correlations were observed between fruit metabolites capsaicin, dihydrocapsaicin, hexadecanoic acid, cyclopentane, α-tocopherol and antioxidant activity. Furthermore, comparative expression analysis (through qRT-PCR) of candidate genes involved in capsaicinoid biosynthesis pathway revealed many fold higher expression of majority of the genes in C. chinense compared to C. frutescens and C. annuum suggesting that the possible reason for extremely high pungency might be due to the higher level of candidate gene(s) expression although nucleotide variation in pungency related genes may also be involved in imparting variations in level of pungency.
Agomelatine efficacy and acceptability revisited: systematic review and meta-analysis of published and unpublished randomised trials.

BACKGROUND Agomelatine is a novel antidepressant drug with narrative, non-systematic reviews making claims of efficacy. AIMS The present study systematically reviewed published and unpublished evidence of the acute and long-term efficacy and acceptability of agomelatine compared with placebo in the treatment of major depression. METHOD Randomised controlled trials comparing agomelatine with placebo in the treatment of unipolar major depression were systematically reviewed. Primary outcomes were (a) Hamilton Rating Scale for Depression (HRSD) score at the end of treatment (short-term studies) and (b) number of relapses (long-term studies). RESULTS Meta-analyses included 10 acute-phase and 3 relapse prevention studies. Seven of the included studies were unpublished. Acute treatment with agomelatine was associated with a statistically significant superiority over placebo of -1.51 HRSD points (99% CI -2.29 to -0.73, nine studies). Data extracted from three relapse prevention studies failed to show significant effects of agomelatine over placebo (relative risk 0.78, 99% CI 0.41-1.48). Secondary efficacy analyses showed a significant advantage of agomelatine over placebo in terms of response (with no effect for remission). None of the negative trials were published and conflicting results between published and unpublished studies were observed. CONCLUSIONS We found evidence suggesting that a clinically important difference between agomelatine and placebo in patients with unipolar major depression is unlikely. There was evidence of substantial publication bias.
Planning, Executing, and Evaluating the Winograd Schema Challenge

The Winograd Schema Challenge was proposed by Hector Levesque in 2011 as an alternative to the Turing Test. Chief among its features is a simple question format that can span many commonsense knowledge domains. Questions are chosen so that they do not require specialized knoweldge or training, and are easy for humans to answer. This article details our plans to run the WSC and evaluate results.
Estimating available capacity of a network connection

Capacity measures for a network connection across the Internet are useful to many applications. Its applicability encompasses QoS guarantees, congestion control and other related areas. In this paper we define and measure the available capacity of a connection, through observations at endpoints only. Our measurements account for the variability of cross traffic that passes through the routers handling this connection. Related to the estimation of available capacity, we suggest modifications to current techniques to measure the packet service time of the "bottleneck" router of the connection. Finally, we present estimation results on wide-area network connections from our experiments to multiple sites.
A 22.5-to-32-Gb/s 3.2-pJ/b Referenceless Baud-Rate Digital CDR With DFE and CTLE in 28-nm CMOS

This paper presents a referenceless baud-rate clock and data recovery (CDR) incorporated with a continuous-time linear equalizer (CTLE) and one-tap decision feedback equalizer (DFE) to achieve data rates from 22.5 to 32 Gb/s across a channel with Nyquist loss ranging from 10.1 to 14.8 dB. The referenceless CDR includes a proposed frequency acquisition scheme that consists of two parts: frequency detection and frequency correction. Frequency detection is achieved by examining rising and falling data waveforms to detect discrepancies between the data rate and the locally recovered clock frequency. Frequency correction uses digitally adjustable asymmetry of the proposed adjustable baud-rate phase detector to correct any frequency error. The receiver is implemented in the TSMC 28-nm CMOS process with an analog front end consisting of a CTLE, sampling comparators, a digitally controlled oscillator, and a digital back end consisting of synthesized digital CDR logic. The open-loop frequency detector range is measured to be 39%. The closed-loop CDR capture range is measured to be 34%, limited by test equipment. The proposed frequency acquisition scheme improves the measured CDR capture range by up to $227\times $ . At 32 Gb/s, the entire receiver consumes 102.04 mW, achieving energy consumption below 3.19 pJ/b.
The Heterodigital Reversed Flow Neurovascular Island Flap for Fingertip Injuries

We report the results of pulp reconstruction with a new heterodigital reverse flow island flap. A dorsolateral flap from the middle phalanx, based on the digital artery is raised from the adjacent uninjured finger. The common digital artery, between the injured finger and the donor finger, is ligated and transected just before its bifurcation. The two converging branches of the digital arteries can be entirely mobilized as a continuous vascular pedicle for the flap. Thus the vascularization is now supplied by reverse flow through the proximal transverse digital palmar arch of the injured finger. To provide sensation the dorsal branch of the proper digital nerve from the donor finger can be included in the flap. Six reverse heterodigital island flaps were used in patients. In five patients the flap was used for pulp reconstruction and in one case for covering a dorsal digital defect. In one case mild venous congestion occurred. Good skin coverage with supple and well-vascularized skin was obtained in each patient. The static two-point discrimination over the flap was between 6 and 15 mm. This new procedure is indicated for extensive pulp defects in fingers in which reconstruction cannot be done using other flaps and as an alternative to microsurgical reconstruction.
The relationship between dimensions of religiosity/spirituality with mental health and hope for future between staff of public hospitals in Shiraz

Introduction: Due to the impacts of spirituality and its dimensions on psychological structures in the workplace and their ability to influence organizational performances have received a great attention in recent years. Thus, this study investigated the relationship between dimensions of spirituality with mental health and hope for future. Materials and Methods: This is a correlational study with a statistical population, including public Hospital's personnel of Shiraz done in autumn 1389. To collect the research data, three different types of questionnaires were used: (1) Hope for the future (4 items), (2) mental health (12 items), and (3) components of religiosity/spirituality at (31 items and based on 5 components). Data were analyzed using Pearson's correlation and Hierarchical regression analysis. Findings: Research findings show that there are significant correlations between existential well-being and hope for the future, motivation, devotion and coping and hope for the future, and mental health and hope for the future. Furthermore, all components of religiosity/spirituality have had significant correlations with mental health. Hierarchical regression analysis showed that in the first step motivation, devotion and coping with a variance of 5%, in the second step motivation, devotion and coping with mental health with a variance of 6.4%, in the third step motivation, devotion and coping with mental health and existential well-being with a variance of 9.1% and in the fourth step, the combining of motivation, devotion and coping and existential well-being with a variance of 8.9% with hope for the future have meaningful multiple relationships. Conclusion: Findings indicated that motivation, devotion and coping with existential well-being, respectively, were the most important dimensions of religiosity-spirituality that together with mental health affect hope for future. It is necessary that the dimension of motivation, devotion and coping, existential well-being and personnel mental health should be strengthened to increase the staff's hope for future.
The role of particle shape on the stress distribution in a sandpile

The results of an experimental investigation into the counter-intuitive phenomenon that a local minimum in the normal stress profile is sometimes found under the apex of a sandpile are presented. Specifically, the effects of particle shape on the stress distribution are studied and it is shown that anisotropy of the particles significantly enhances the dip. This amplification is attributed to the mechanical stability induced by boundary alignment of the anisotropic particles. Circular, ellipsoidal and pear-shaped cylinders are used and the stress propagates principally towards the sides of the pile through primary stress chains. Secondary chains are also present and we propose that the relationship between the magnitudes of the ratio of primary to secondary chains is correlated with the size of the dip.
Applications of a numerical geometry system in engineering

In December of 1972, a study effort was undertaken at TRA to determine if it was feasible to create a computer based system that would significantly improve the generation, usage and dissemination of geometric information in an engineering, design and manufacturing environment. The effort was divided into several phases: study, system design and economic evaluation and, finally, implementation. The system which has been implemented is a highly interactive keystroke driven system which executes under the TSO (Time Sharing Option) provided on IBM computers. The specific functional capabilities provided by the system appear to the end user as an extension of the time sharing system command language.
Adaptive Learning Systems: Beyond Teaching Machines

Since 1950s, teaching machines have changed a lot. Today, we have different ideas about how people learn, what instructor should do to help students during their learning process. We have adaptive learning technologies that can create much more student oriented learning environments. The purpose of this article is to present these changes and its effects on learning environment. First, after explaining the concepts of teaching machines and adaptive learning systems including their main features as well as integral components, similarities and differences between these technologies are discussed briefly. Then, following the discussion on weaknesses and strengths of adaptive learning systems, what instructional designers should consider in developing and using them are mentioned.
Accurate noninvasive measurement of cell size and compartment shape anisotropy in yeast cells using double‐pulsed field gradient MR

The accurate characterization of pore morphology is of great interest in a wide range of scientific disciplines. Conventional single‐pulsed field gradient (s‐PFG) diffusion MR can yield compartmental size and shape only when compartments are coherently ordered using q‐space approaches that necessitate strong gradients. However, double‐PFG (d‐PFG) methodology can provide novel microstructural information even when specimens are characterized by polydispersity in size and shape, and even when anisotropic compartments are randomly oriented. In this study, for the first time, we show that angular d‐PFG experiments can be used to accurately measure cellular size and shape anisotropy of fixed yeast cells employing relatively weak gradients. The cell size, as measured by light microscopy, was found to be 5.32 ± 0.83 µm, whereas the results from noninvasive angular d‐PFG experiments yielded a cell size of 5.46 ± 0.45 µm. Moreover, the low compartment shape anisotropy of the cells could be inferred from experiments conducted at long mixing times. Finally, similar experiments were conducted in a phantom comprising anisotropic compartments that were randomly oriented, showing that angular d‐PFG MR provides novel information on compartment eccentricity that could not be accessed using conventional methods. Angular d‐PFG methodology seems to be promising for the accurate estimation of compartment size and compartment shape anisotropy in heterogeneous systems in general, and biological cells and tissues in particular. Copyright © 2011 John Wiley & Sons, Ltd.
Why Steiner-tree type algorithms work for community detection

We consider the problem of reconstructing a specific connected community S ⊂ V in a graph G = (V,E), where each node v is associated with a signal whose strength grows with the likelihood that v belongs to S. This problem appears in social or protein interaction network, the latter also referred to as the signaling pathway reconstruction problem (Bailly-Bechet et al., 2011). We study this community reconstruction problem under several natural generative models, and make the following two contributions. First, in the context of social networks, where the signals are modeled as boundedsupported random variables, we design an efficient algorithm for recovering most members in S with well-controlled false positive overhead, by utilizing the network structure for a large family of “homogeneous” generative models. This positive result is complemented by an information theoretic lower bound for the case where the network structure is unknown or the network is heterogeneous. Second, we consider the case in which the graph represents the protein interaction network, in which it is customary to consider signals that have unbounded support, we generalize our first contribution to give the first theoretical justification of why existing Steiner-tree type heuristics work well in practice.
Natural history of cow's milk allergy. An eight-year follow-up study in 115 atopic children.

BACKGROUND Cow's milk allergy (CMA) is a disease of infancy and usually appears in the first few months of life. The evaluation of infants for possible CMA is one of the more common problems shared by pediatricians. The role of foods in determining and/or aggravating the clinical features of atopic dermatitis (AD) has been stressed in the last decades. OBJECTIVE The aim of the present study was to investigate, in children with food related AD, the development of tolerance to the offending food(s), clinical or laboratory data to predict the development of food tolerance, and whether there are clinical or laboratory data to predict the onset of respiratory allergy. MATERIALS AND METHODS In this prospective study we report on 115 babies, first examined at a median age of 6 months, and followed-up for 8 years. We have investigated several factors as predictive of the outcome, as follows: early onset; widespread or not-typical (reverse pattern) skin lesions, family history positive for atopy; persisting FA, high levels of total and specific IgE antibodies, association with CMA and asthma. RESULTS All these parameters were significantly predictive of a long-term morbidity of AD children with CMA. The median age for tolerance to cow's milk was 7 years + 11 months, to egg 6 years + 6 months, and to wheat 7 years + 2 months. However a great number of both tolerant and intolerant children developed multiple sensitizations. Only 66 children (57%) acquired food tolerance, but there was the onset of asthma in 54% of cases. CONCLUSION The natural history of CMA is not well-known, since not many related studies have been done in children. The several predictive factors, all in a negative sense, may be the norm in atopic children. We suggest possible areas of intervention in children at risk due to parental atopy. Preventive measures may induce a dramatic improvement in children with food allergy, but we stress that the long-term prognosis is challenging, since asthma prevalence may increase up to 54% during a long follow-up. Therefore, the natural history of IgE-mediated AD in atopic children sensitized to several allergens may be less optimistic than generally reported.