Miracle-dz/UniFAR-FTUs huggingface dataset:
PHIBSS: MOLECULAR GAS, EXTINCTION, STAR FORMATION, AND KINEMATICS IN THE z = 1.5 STAR-FORMING GALAXY EGS13011166

We report matched resolution imaging spectroscopy of the CO 3–2 line (with the IRAM Plateau de Bure millimeter interferometer) and of the Hα line (with LUCI at the Large Binocular Telescope) in the massive z = 1.53 main-sequence galaxy EGS 13011166, as part of the “Plateau de Bure high-z, blue-sequence survey” (PHIBSS: Tacconi et al.). We combine these data with Hubble Space Telescope V–I–J–H-band maps to derive spatially resolved distributions of stellar surface density, star formation rate, molecular gas surface density, optical extinction, and gas kinematics. The spatial distribution and kinematics of the ionized and molecular gas are remarkably similar and are well modeled by a turbulent, globally Toomre unstable, rotating disk. The stellar surface density distribution is smoother than the clumpy rest-frame UV/optical light distribution and peaks in an obscured, star-forming massive bulge near the dynamical center. The molecular gas surface density and the effective optical screen extinction track each other and are well modeled by a “mixed” extinction model. The inferred slope of the spatially resolved molecular gas to star formation rate relation, N = dlogΣstar form/dlogΣmol gas, depends strongly on the adopted extinction model, and can vary from 0.8 to 1.7. For the preferred mixed dust–gas model, we find N = 1.14 ± 0.1.
Mouse kidney expresses mRNA of four highly related sodium-glucose cotransporters: regulation by cadmium.

BACKGROUND To study the molecular mechanism responsible for cadmium-induced Fanconi syndrome, an in vitro mouse model has been used. We have previously shown that exposure of primary cultures of kidney cortical cells to micromolar concentrations of cadmium inhibited uptake of the glucose analog, [14C] methyl alpha-d-glucopyranoside (AMG) (261 mCi/mmol, NEN), and decreased mRNA levels of two kidney sodium-glucose cotransporters (SGLTs), SGLT1 and SGLT2. We also isolated partial cDNA of another member of the SGLT family, SGLT3-b, from cultured kidney cells and observed that cadmium exposure increased the abundance of its mRNA. In this study, we investigated the effect of cadmium on the second mouse kidney SGLT3 isoform, SGLT3-a. We also examined which SGLTs were transcribed in vivo. METHODS Cadmium was added to the confluent primary cultures of kidney cortical cells at concentrations of 5, 7.5, and 10 micromol/L. After 24 hours, uptake of [14C]AMG was measured and total RNA was extracted for semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) of SGLT3-a. Also, cDNA from whole kidneys of mice was used in PCR with primers specific for each SGLT. A partial cDNA sequence of SGLT3-a and the full-length cDNA sequence of SGLT3-b were obtained from their respective PCR clones. RESULTS Exposure of cortical cells to 5 micromol/L cadmium increased SGLT3-a mRNA level 3.4- +/- 0.78-fold (mean +/- SEM, P < 0.03, N = 5). mRNAs of SGLT1, SGLT2, SGLT3-a, and SGLT3-b were simultaneously present in cDNA samples from whole kidneys of mice. SGLT3-b cDNA sequence was revised from its predicted sequence to encode a 660 amino acid protein. CONCLUSION Reabsorption of glucose in mouse kidney may involve four SGLTs. Cadmium affects mRNA expression of all four SGLTs in vitro.
Decoding Finger Movements from ECoG Signals Using Switching Linear Models

One of the most interesting challenges in ECoG-based Brain-Machine Interface is movement prediction. Being able to perform such a prediction paves the way to high-degree precision command for a machine such as a robotic arm or robotic hands. As a witness of the BCI community increasing interest toward such a problem, the fourth BCI Competition provides a dataset which aim is to predict individual finger movements from ECoG signals. The difficulty of the problem relies on the fact that there is no simple relation between ECoG signals and finger movements. We propose in this paper, to estimate and decode these finger flexions using switching models controlled by an hidden state. Switching models can integrate prior knowledge about the decoding problem and helps in predicting fine and precise movements. Our model is thus based on a first block which estimates which finger is moving and another block which, knowing which finger is moving, predicts the movements of all other fingers. Numerical results that have been submitted to the Competition show that the model yields high decoding performances when the hidden state is well estimated. This approach achieved the second place in the BCI competition with a correlation measure between real and predicted movements of 0.42.
The Rapidity with Which Virus-Specific CD8+ T Cells Initiate IFN-γ Synthesis Increases Markedly over the Course of Infection and Correlates with Immunodominance1

Primary CD8+ T cell responses play a major role in controlling infection by many viruses, and CD8+ memory T cells can confer immunity to virus challenge. In this study we report that for many epitope-specific CD8+ T cell populations, the regulation of an important effector molecule, IFN-γ, changes dramatically over the course of infection. During the acute phase of infection, many CD8+ T cells exhibit a significant lag before producing IFN-γ in response to Ag contact; in contrast, the onset of IFN-γ production by memory cells of the same epitope specificity is markedly accelerated. The biological consequences of this improved responsiveness are manifold. Moreover, during the acute phase of the CD8+ T cell response when immunodominance is being established, there is a strong correlation (p = 0.0002) between the abundance of each epitope-specific T cell population and the rapidity with which it initiates IFN-γ synthesis. Previous studies have indicated that IFN-γ plays a critical role in determining the immunodominance hierarchy of an on-going T cell response, and in this report we present evidence for an underlying mechanism: we propose that the CD8+ T cells that most rapidly initiate IFN-γ production may be at a selective advantage, permitting them to dominate the developing T cell response.
Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures

The mechanisms of intramembrane proteases are incompletely understood due to the lack of structural data on substrate complexes. To gain insight into substrate binding by rhomboid proteases, we have synthesised a series of novel peptidyl‐chloromethylketone (CMK) inhibitors and analysed their interactions with Escherichia coli rhomboid GlpG enzymologically and structurally. We show that peptidyl‐CMKs derived from the natural rhomboid substrate TatA from bacterium Providencia stuartii bind GlpG in a substrate‐like manner, and their co‐crystal structures with GlpG reveal the S1 to S4 subsites of the protease. The S1 subsite is prominent and merges into the ‘water retention site’, suggesting intimate interplay between substrate binding, specificity and catalysis. Unexpectedly, the S4 subsite is plastically formed by residues of the L1 loop, an important but hitherto enigmatic feature of the rhomboid fold. We propose that the homologous region of members of the wider rhomboid‐like protein superfamily may have similar substrate or client‐protein binding function. Finally, using molecular dynamics, we generate a model of the Michaelis complex of the substrate bound in the active site of GlpG.
Bayesian Persuasion

When is it possible for one person to persuade another to change her action? We take a mechanism design approach to this question. Taking preferences and initial beliefs as given, we introduce the notion of a persuasion mechanism: a game between Sender and Receiver defined by an information structure and a message technology. We derive necessary and sufficient conditions for the existence of a persuasion mechanism that strictly benefits Sender. We characterize the optimal mechanism. Finally, we analyze several examples that illustrate the applicability of our results.
Correlations between nutrient concentrations and zooplankton populations in a mesotrophic reservoir

SUMMARY 1. A year-round study was conducted in a mesotrophic reservoir to determine the dynamics of zooplankton populations as a function of food availability (edible phytoplankton), nutrient concentration, temperature and hydraulic regime. 2. Rotifer biomass was correlated with soluble reactive phosphorus (SRP) concentration. The abundance of the rotifers Keratella cochlearis and Anuraeopsis fissa were not correlated with food availability (measured by chlorophyll and cell counts) but showed a strong dependence on P availability. Another rotifer, Synchaeta oblonga, and crustacean species were not related to nutrient availability but seemed to be dependent on food concentrations, especially of some phytoplankton taxa. 3. In this field study, rotifers seemed more susceptible than Daphnia or copepods to P-limitation. Among rotifer species, Keratella seemed to be more susceptible than Anuraeopsis to P limitation. Different susceptibilities of zooplankton species to nutrient limitation may be important in explaining the dynamics of these organisms in natural situations. Further analyses are warranted to clarify the interactions between nutrient limitation and energy limitation among zooplankton.
Identification of Map4k4 as a Novel Suppressor of Skeletal Muscle Differentiation

ABSTRACT Myoblast differentiation into mature myotubes is a critical step in the development and repair of human skeletal muscle. Here we show that small interfering RNA (siRNA)-based silencing of the Ste20-like mitogen-activated protein 4 kinase 4 (Map4k4) in C2C12 myoblasts markedly enhances expression of myogenic differentiation genes, myoblast fusion, and myotube diameter. In contrast, adenovirus-mediated expression of native Map4k4 in C2C12 cells attenuates each of these processes, indicating that Map4k4 is a negative regulator of myogenic differentiation and hypertrophy. Expression of a Map4k4 kinase-inactive mutant enhances myotube formation, suggesting that the kinase activity of Map4k4 is essential for its inhibition of muscle differentiation. Map4k4 regulation of myogenesis is unlikely to be mediated by classic mitogen-activated protein kinase (MAPK) signaling pathways, because no significant difference in phosphorylation of extracellular signal-regulated kinase (ERK), p38, or c-Jun N-terminal kinase (JNK) is observed in Map4k4-silenced cells. Furthermore, silencing of these other MAPKs does not result in a hypertrophic myotube phenotype like that seen with Map4k4 depletion. Uniquely, Map4k4 silencing upregulates the expression of the myogenic regulatory factor Myf5, whose depletion inhibits myogenesis. Furthermore, Myf5 is required for enhancement of myotube formation in Map4k4-silenced cells, while Myf5 overexpression rescues Map4k4-mediated inhibition of myogenic differentiation. These results demonstrate that Map4k4 is a novel suppressor of skeletal muscle differentiation, acting through a Myf5-dependent mechanism.
HUMAN IMPACTS HAVE SHAPED HISTORICAL AND RECENT EVOLUTION IN AEDES AEGYPTI, THE DENGUE AND YELLOW FEVER MOSQUITO

Although anthropogenic impacts are often considered harmful to species, human modifications to the landscape can actually create novel niches to which other species can adapt. These “domestication” processes are especially important in the context of arthropod disease vectors, where ecological overlap of vector and human populations may lead to epidemics. Here, we present results of a global genetic study of one such species, the dengue and yellow fever mosquito, Aedes aegypti, whose evolutionary history and current distribution have been profoundly shaped by humans. We used DNA sequences of four nuclear genes and 1504 single nucleotide polymorphism (SNP) markers developed with restriction‐site associated DNA (RAD) sequencing to test the hypothesis that Ae. aegypti originated in Africa, where a domestic form arose and spread throughout the tropical and subtropical world with human trade and movement. Results confirmed African ancestry of the species, and supported a single subspeciation event leading to the pantropical domestic form. In addition, genetic data strongly supported the hypothesis that human trade routes first moved domestic Ae. aegypti out of Africa into the New World, followed by a later invasion from the New World into Southeast Asia and the Pacific. These patterns of domestication and invasion are relevant to many species worldwide, as anthropogenic forces increasingly impact evolutionary processes.
THE EFFECTS OF A TRAINING PACKAGE ON THE USE OF INCLUSIVE TEACHER BEHAVIORS IN A SUNDAY SCHOOL CLASS

OF THESIS THE EFFECTS OF A TRAINING PACKAGE ON THE USE OF INCLUSIVE TEACHER BEHAVIORS IN A SUNDAY SCHOOL CLASS The purpose of the study was to provide training and follow-up sessions for Sunday school teachers to increase the use of inclusive teacher behaviors (opportunities to respond, behavior specific praise, and opportunities to participate) for educating a child with moderate to severe disability. A multiple baseline across behaviors design was used to evaluate the effectiveness of training and follow-up sessions for a Sunday school teacher that had a child with moderate to severe disability in her class. The results showed training and follow-up were effective in teaching inclusive teacher behaviors within a church setting.
Current trends in athletic training practice for concussion assessment and management.

CONTEXT Athletic trainers surveyed in 1999 demonstrated little consensus on the use of concussion grading scales and return-to-play criteria. Most relied on clinical examination or symptom checklists to evaluate athletes with concussion. OBJECTIVE To investigate the current trends of certified athletic trainers in concussion assessment and management. DESIGN Subjects were invited to participate in a 32-question Internet survey. SETTING An Internet link to the survey was e-mailed to the subjects. PATIENTS OR OTHER PARTICIPANTS A total of 2750 certified athletic trainers and members of the National Athletic Trainers' Association were randomly e-mailed and invited to participate. MAIN OUTCOME MEASURE(S) Survey questions addressed topics including years of certification, number of concussions evaluated each year, methods of assessing concussion, and guidelines used for return to play. Compliance with the recent position statement of the National Athletic Trainers' Association on sport-related concussion was also evaluated. RESULTS Certified athletic trainers averaged 9.9 +/- 7.3 years of certification and evaluated an average of 8.2 +/- 6.5 concussions per year. To assess concussion, 95% reported using the clinical examination, 85% used symptom checklists, 48% used the Standardized Assessment of Concussion, 18% used neuropsychological testing, and 16% used the Balance Error Scoring System. The most frequently used concussion grading scale and return-to-play guideline belonged to the American Academy of Neurology (30%). When deciding whether to return an athlete to play, certified athletic trainers most often used the clinical examination (95%), return-to-play guidelines (88%), symptom checklists (80%), and player self-report (62%). The most important tools for making a return-to-play decision were the clinical examination (59%), symptom checklists (13%), and return-to-play guidelines (12%). Only 3% of certified athletic trainers surveyed complied with the recent position statement, which advocated using symptom checklists, neuropsychological testing, and balance testing for managing sport-related concussion. CONCLUSIONS Our findings suggest that only a small percentage of certified athletic trainers currently follow the guidelines proposed by the National Athletic Trainers' Association. Various assessment methods and tools are currently being used, but clinicians must continue to implement a combination of methods and tools in order to comply with the position statement.
RIO: A denial of service experimentation platform in a Future Internet Testbed

Denial of service attacks (DoS) present a serious threat to the security of communication network infrastructure. Whereas the dissemination of new DoS attacks is fast and dynamic, the development of countermeasures to these attacks requires the construction and validation of a test environment that accurately reproduces Internet behavioral patterns. The construction of this environment often requires more time investment from security professionals than the time spent with the development of associated attack countermeasures. This work introduces RIO (Resource Orchestration Infrastructure) platform. RIO platform enables security professional a realistic and flexible approach to DoS experimentation creation and setup. This platform automates the creation and setup of virtual machines, virtual switches, network links, attackers, experimental data collection and experiment execution, based on a single document defining the experiment in a descriptive language. The proposal efficacy is supported by RIO platform ease of use and time reduction towards the acquisition of experimental results.
Faculty Careers and Work Lives: A Professional Growth Perspective

This volume reviews and synthesizes recent research on faculty demographics, appointment types, work life, and reward systems, as well as major theoretical perspectives useful to researchers who study faculty work, careers, and professional development. In doing so, it advances and challenges current dialogue on faculty careers, notably by exploring a "narrative of constraint" that underlies much contemporary research and reform in higher education. Although highlighting the valuable ways whereby the "narrative of constraint" has illuminated the myriad barriers than can--and too often do--inhibit faculty careers, the authors assert that the theme of "constraint" obscures possibility, learning, agency, and growth. In emphasizing constraint, many contemporary research and reform efforts overlook faculty striving for growth. The volume reintroduces growth as an important consideration in higher education discourses of policy and practice, and with attention to four of its key aspects: learning, agency, professional relationships, and commitments. The authors discuss current research on faculty demographics, appointments, work, reward systems, along with theories used in research, relative to these four aspects of growth. They also discuss how attention to faculty growth my open up new directions for policy, public communication, and future research on higher education faculty. This is the third issue in the 34th volume of the Jossey-Bass series ASHE Higher Education Report. Each monograph in the series is the definitive analysis of a tough higher education problem, based on thorough research of pertinent literature and institutional experiences. Topics are identified by a national survey. Noted practitioners and scholars are then commissioned to write the reports, with experts providing critical reviews of each manuscript before publication.
The case for using DUOLINGO as part of the language classroom experience Duolingo como parte del curriculum de las clases de lengua extranjera

This article explores the idea of using an already existing language learning app, Duolingo, to complement traditional college level Spanish as second language courses. These types of apps use adaptive learning technologies, which are able to tailor the tasks to the level of each student. In the case of this study, Duolingo was used as part of the program of studies in two Spanish university courses, one a beginner’s Spanish course (level A1) and the other an advanced intermediate course (B2). The students used the app online, either in its mobile version or in their web browser. I will describe how Duolingo operates, what kind of activities can be done, and how learning is achieved. Preliminary results suggest that Duolingo is an easy-to-use app that is useful and has potential, although its main lessons are not based on communicative competence. It is usually enjoyed by students because of several elements, such as the accessibility on a mobile device, its gamification aspect, and the variety of tasks. I will discuss possible ways to incorporate Duolingo into foreign language courses, always considering it as a complement to the curriculum, but considering its value to reinforce vocabulary and grammar acquisition through spaced repetition, interleaving of different skills and variety of activities.
Compile-Time Partitioning of Iterative Parallel Loops to Reduce Cache Coherency Traffic

Adaptive data partitioning (ADP) which reduces the execution time of parallel programs by reducing interprocessor communication for iterative parallel loops is discussed. It is shown that ADP can be integrated into a communication-reducing back end for existing parallelizing compilers or as part of a machine-specific partitioner for parallel programs. A multiprocessor model to analyze program execution factors that lead to interprocessor communication and a model for the iterative parallel loop to quantify communication patterns within a program are defined. A vector notation is chosen to quantify communication across a global data set. Communication parameters are computed by examining the indexes of array accesses and are adjusted to reflect the underlying system architecture by compensating for cache line sizes. These values are used to generate rectangular and hexagonal partitions that reduce interprocessor communication. >
Comparing two methods of topical anesthesia used before intravenous cannulation in pediatric patients.

INTRODUCTION The purpose of this study was to compare the efficacy of two methods of topical anesthesia before venipuncture or intravenous cannulation of pediatric patients to assess which type of topical anesthetic would better alleviate pain in the least amount of time with the greatest success rate of cannulation. METHODS This study was a randomly controlled trial of 100 preoperative pediatric patients aged 5 to 21 years. The following methods of topical anesthesia were compared: (a) iontophoresis of a topical solution of 2% lidocaine with epinephrine 1:100,000 using a Phoresor Dose Controller (PDC) with Numby Stuff electrodes and a eutectic mixture of local anesthetic and (b) 2.5% lidocaine and 2.5% prilocaine (eutectic mixture of local anesthetics [EMLA] cream). RESULTS Children reported less pain with iontophoresis (M = 0.08) compared with EMLA cream (M = 1.88, P < .001). Time to accomplish topical anesthesia was shorter with iontophoresis (13 minutes) compared with EMLA cream (60 minutes, P < .001). Failure to accomplish venipuncture occurred 5 times with the iontophoresis method and 8 times with the EMLA method (not significant). No dermal burns resulted from use of iontophoresis. DISCUSSION We conclude that use of iontophoresis in pediatric patients is safe, rapid, and significantly more effective than is EMLA cream in reducing pain associated with venipuncture or intravenous cannulation.