Miracle-dz/UniFAR-FTUs huggingface dataset:
The Influence of Explicit Instructions and Stimulus Material on Lateral Frontal Responses to an Encoding Task

In this functional magnetic resonance imaging study, we explored the effects of both stimulus material and encoding task demands on activation in lateral prefrontal cortex (PFC). Two factors were manipulated: material type and task instructions. Subjects encoded words or abstract figures (factor 1: stimulus type) and were required to make either a meaning-based or a form-based (letter or shape) decision about each stimulus (factor 2: task instructions). Abstract figures engendered significantly higher levels of right PFC activity than did words. This effect was seen for meaning-based and form-based processing tasks and was significantly greater for the former. We did not observe a differential response of left lateral PFC to verbal and pictorial material. A double dissociation, however, was found within left PFC. A ventrolateral region (within left inferior frontal gyrus) showed the highest levels of activity when words were processed according to their meaning whereas activity in a more dorsolateral region (within left middle frontal gyrus) was greatest when words were processed according to their form (constituent letters). We have therefore observed a main effect of material type in producing lateralized activation of frontal lobes, although the strength of this effect is sensitive to the nature of the task that subjects are asked to perform. Left-side lateral PFC activity is also sensitive to task instructions but this effect was specific to verbal material. The complex patterns of frontal effect counsel against any simple dichotomy of frontal function at the level of either material or task type.
Using the Web to Train a Mobile Device Oriented Japanese Input Method Editor

This paper describes the construction of a Japanese Input Method Editor (IME) system for mobile devices, using the largescale Web pages. We provide the training process of our IME model, n-pos model for local Kana-Kanji conversion and ngram model for online cloud service. Especially, we propose an online algorithm of mining new compound words, together with the detailed post-filtering process to prune the billion level entries to be used in mobile services. Experiments show that our IME system outperforms two state-ofthe-art Japanese IME baselines. We have released our system in a completely free form 1 and the system is currently used by millions of users.
Comparison of Cross‐Sectional Geometry of the Proximal Femur in White and Black Women from Detroit and Johannesburg

There are known black‐white differences in bone density measured by DXA but less is known about bone architecture. We compared cross‐sectional geometric properties of the proximal femur in U.S. black (n = 86) and white (n = 151) and South African black (n = 60) and white (n = 48) postmenopausal women. Results are consistent with greater bone strength in the black groups in both countries.
Thermal Analysis of a PMaSRM Using Partial FEA and Lumped Parameter Modeling

This paper presents an advanced lumped parameter (LP) thermal model for a permanent-magnet assisted synchronous reluctance machine (PMaSRM) developed for propulsion in a hybrid electric vehicle. Particular focus is put on the stator winding and a thermal model is proposed that divides the stator slot into a number of elliptical copper and impregnation layers. The model is enabled by the derivation of an approximate analytical expression for the thermal resistance of an elliptical cylinder with constant thickness. The approach is attractive due to its simplicity and the fact that it closely models the actual temperature distribution for common slot geometries. Additionally, an analysis, using results from a proposed simplified thermal finite element model representing only one slot of the stator and its corresponding end winding, is presented in which the number of layers and the proper connection between the parts of the LP thermal model representing the end winding and the active part of winding is determined. The presented thermal model is evaluated experimentally on a PMaSRM equipped with a water cooling jacket, and a good correspondence between the predicted and measured temperatures is obtained.
Mitochondrial calcium overload is a key determinant in heart failure

Significance We demonstrate that intracellular Ca2+ leak causes mitochondrial Ca2+ overload and dysfunction in postischemic heart failure (HF). In particular, sarcoplasmic reticulum (SR) Ca2+ leak via type 2 ryanodine receptor (RyR2)—but not type 2 inositol 1,4,5-trisphosphate receptor (IP3R2)—channels plays a fundamental role in the pathophysiology of mitochondrial Ca2+ overload and dysfunction in HF. We present here a previously undisclosed molecular mechanism in HF with crucial implications in cardiac physiology. Indeed, our data establish a feedback loop between SR and mitochondria in which SR Ca2+ leak triggers mitochondrial dysfunction and increases the production of free radicals, which in turn lead to posttranslational modifications of RyR2 and enhance intracellular Ca2+ leak, thereby contributing to impaired cardiac function after myocardial infarction. Calcium (Ca2+) released from the sarcoplasmic reticulum (SR) is crucial for excitation–contraction (E–C) coupling. Mitochondria, the major source of energy, in the form of ATP, required for cardiac contractility, are closely interconnected with the SR, and Ca2+ is essential for optimal function of these organelles. However, Ca2+ accumulation can impair mitochondrial function, leading to reduced ATP production and increased release of reactive oxygen species (ROS). Oxidative stress contributes to heart failure (HF), but whether mitochondrial Ca2+ plays a mechanistic role in HF remains unresolved. Here, we show for the first time, to our knowledge, that diastolic SR Ca2+ leak causes mitochondrial Ca2+ overload and dysfunction in a murine model of postmyocardial infarction HF. There are two forms of Ca2+ release channels on cardiac SR: type 2 ryanodine receptors (RyR2s) and type 2 inositol 1,4,5-trisphosphate receptors (IP3R2s). Using murine models harboring RyR2 mutations that either cause or inhibit SR Ca2+ leak, we found that leaky RyR2 channels result in mitochondrial Ca2+ overload, dysmorphology, and malfunction. In contrast, cardiac-specific deletion of IP3R2 had no major effect on mitochondrial fitness in HF. Moreover, genetic enhancement of mitochondrial antioxidant activity improved mitochondrial function and reduced posttranslational modifications of RyR2 macromolecular complex. Our data demonstrate that leaky RyR2, but not IP3R2, channels cause mitochondrial Ca2+ overload and dysfunction in HF.
Cathepsin X Cleaves Profilin 1 C-Terminal Tyr139 and Influences Clathrin-Mediated Endocytosis

Cathepsin X, a cysteine carboxypeptidase, is upregulated in several types of cancer. Its molecular target in tumor cells is profilin 1, a known tumor suppressor and regulator of actin cytoskeleton dynamics. Cathepsin X cleaves off the C-terminal Tyr139 of profilin 1, affecting binding of poly-L-proline ligands and, consequently, tumor cell migration and invasion. Profilin 1 with mutations at the C-terminus, transiently expressed in prostate cancer cells PC-3, showed that Tyr139 is important for proper function of profilin 1 as a tumor suppressor. Cleaving off Tyr139 prevents the binding of clathrin, a poly-L-proline ligand involved in endocytosis. More profilin 1—clathrin complexes were present in PC-3 cells when cathepsin X was inhibited by its specific inhibitor AMS36 or silenced by siRNA. As a consequence, the endocytosis of FITC-labeled dextran and transferrin conjugate was significantly increased. These results constitute the first report of the regulation of clathrin-mediated endocytosis in tumor cells through proteolytic processing of profilin 1.
How executive coaches use the results of the Myers-Briggs Type Indicator to develop their coachees

xiii Chapter One: The Problem . 1 Background of the Problem . 2 Purpose and Importance of the Study . 3 Statement of the Problem . 6 Research Question . 7 Clarification of Terms . 7 Summary . 9 Chapter Two: Review of Relevant Literature . 10 Executive Coaching . 10 Executive coaching defined . 10 History and growth . 12 Coaching versus psychotherapy . 13 Coachee situations . 17 Coaching process . 19 Coach qualifications . 32 Coaching on difficult issues . 43 Effectiveness of executive coaching . 43 Psychological Type . 47 Development of type theory . 47 The MBTI . 49 Measurements . 50 Application of type theory . 58 Coaching With Psychological Type . 67 Leadership development strategies . 67 Midlife considerations . 73 Benefits of development with psychological type . 73 Summary . 74
Effect of Vernalization, Photoperiod, and Light Quality on the Flowering Phenotype of Arabidopsis Plants Containing the FRIGIDA Gene

We have compared the flowering response to vernalization, photoperiod, and far-red (FR) light of the Columbia (Col) and Landsberg erecta (Ler) ecotypes of Arabidopsis into which the flowering-time locus FRIGIDA (FRI) has been introgressed with that of the wild types Col, Ler, and San Feliu-2 (Sf-2). In the early-flowering parental ecotypes, Col and Ler, a large decrease in flowering time in response to vernalization was observed only under short-day conditions. However, Sf-2 and the Ler and Col genotypes containing FRI showed a strong response to vernalization when grown in either long days or short days. Although vernalization reduced the responsiveness to photoperiod, plants vernalized for more than 80 d still showed a slight photoperiod response. The effect of FRI on flowering was eliminated by 30 to 40 d of vernalization; subsequently, the response to vernalization in both long days and short days was the same in Col and Ler with or without FRI. FR-light enrichment accelerated flowering in all ecotypes and introgressed lines. However, the FR-light effect was most conspicuous in the FRI-containing plants. Saturation of the vernalization effect eliminated the effect of FR light on flowering, although vernalization did not eliminate the increase of petiole length in FR light.
A new noninvasive tear stability analysis system for the assessment of dry eyes.

PURPOSE This was a prospective case-control study conducted to evaluate the effectiveness of the Tear Stability Analysis System (TSAS) for the assessment of patients with dry eye. METHODS The TSAS can take 10 consecutive corneal topograms at one per second for 10 seconds. Examinations using the TSAS were conducted in 26 eyes of 26 healthy control subjects and in 27 eyes of 27 patients with dry eye. Examinations were also conducted in 14 eyes of 14 patients before and after the insertion of punctum plugs. Surface regularity and asymmetry indices (SRI, SAI), as well as new tear stability regularity and asymmetry indices (TSRI, TSAI), derived from SRI and SAI, were analyzed. RESULTS The mean SRI and SAI in dry eyes were significantly greater than in control eyes (P < 0.05). The time-wise change of SRI and SAI was significantly different between dry eyes and control eyes (P < 0.05). TSRI and TSAI in dry eyes were also significantly greater than in control eyes. Punctum plug insertion was associated with a significant decrease in SRI and SAI (P < 0.05). CONCLUSIONS TSAS was effective in objectively assessing the tear stability in patients with dry eye. This system may be useful in noninvasive diagnosis of dry eye and evaluation of treatment effects.
The Dissolution of Language in Alzheimer's Disease

Abstract: Language impairment in Alzheimer's disease has become an important clinical issue. It has been recognized for some time that the disease may begin with aphasia and even before frank aphasia develops, some of the earliest changes in a large number of individuals consist of impairment of word fluency and semantic access manifesting itself in word finding difficulty. The second major issue concerning language in Alzheimer's disease is that the cases which have early severe language impairment may represent a more progressive familial variety of disease as it has been suggested in the literature. This is still subject to controversy. Finally, it will be documented that the later stage of the disease shows language invariably impaired and goes through stages of dissolution that resemble anomic, transcortical sensory, Wernicke's and global aphasias. Accurate assessment of language may turn out to be one of the most reliable predictors of the stages of Alzheimer's disease and provides important insights into the cerebral organization of language, semantic access, relationship of semantic and episodic memory and the pathophysiology of the disease.
Mindfulness starts with the body: somatosensory attention and top-down modulation of cortical alpha rhythms in mindfulness meditation

Using a common set of mindfulness exercises, mindfulness based stress reduction (MBSR) and mindfulness based cognitive therapy (MBCT) have been shown to reduce distress in chronic pain and decrease risk of depression relapse. These standardized mindfulness (ST-Mindfulness) practices predominantly require attending to breath and body sensations. Here, we offer a novel view of ST-Mindfulness's somatic focus as a form of training for optimizing attentional modulation of 7–14 Hz alpha rhythms that play a key role in filtering inputs to primary sensory neocortex and organizing the flow of sensory information in the brain. In support of the framework, we describe our previous finding that ST-Mindfulness enhanced attentional regulation of alpha in primary somatosensory cortex (SI). The framework allows us to make several predictions. In chronic pain, we predict somatic attention in ST-Mindfulness “de-biases” alpha in SI, freeing up pain-focused attentional resources. In depression relapse, we predict ST-Mindfulness's somatic attention competes with internally focused rumination, as internally focused cognitive processes (including working memory) rely on alpha filtering of sensory input. Our computational model predicts ST-Mindfulness enhances top-down modulation of alpha by facilitating precise alterations in timing and efficacy of SI thalamocortical inputs. We conclude by considering how the framework aligns with Buddhist teachings that mindfulness starts with “mindfulness of the body. ” Translating this theory into neurophysiology, we hypothesize that with its somatic focus, mindfulness' top-down alpha rhythm modulation in SI enhances gain control which, in turn, sensitizes practitioners to better detect and regulate when the mind wanders from its somatic focus. This enhanced regulation of somatic mind-wandering may be an important early stage of mindfulness training that leads to enhanced cognitive regulation and metacognition.
One-Time Transfers of Cash or Capital Have Long-Lasting Effects on Microenterprises in Sri Lanka

Cashing Up Do small businesses in developing economies benefit from an infusion of cash or of capital, such as inventory or materials, and is the effect a momentary blip or a sustained expansion? De Mel et al. (p. 962) have extended their study of one-time cash or capital transfers to a group of randomized business owners in Sri Lanka to look at the status of the businesses 5 years later and find an increased likelihood of survival and higher profits for male-owned enterprises, but no significant effects on female-owned businesses. The authors suggest that capital transfers are more likely to be used by male-owned firms to grow the business, but more likely to be “cashed-out” from female-owned firms and diverted to household uses. Small businesses run by the urban poor enjoy greater profits and longevity 5 years after receiving a helping hand. Standard economic theory suggests that one-time business grants can have at most temporary effects, and accordingly, policies to increase incomes of the self-employed in developing countries typically rely on sustained engagement. In contrast, we found long-lasting impacts from one-time grants given in a randomized experiment to subsistence firms. Five years after we gave $100 or $200 to 115 of 197 male and 100 of 190 female Sri Lankan microenterprise owners, we found 10-percentage-point-higher enterprise survival rates, and $8-to-$12-per-month-higher profits for male-owned businesses that received the grants. Female-owned businesses showed no long-term (or short-term) impacts. Our follow-up investigation interviewed 94% of the original sample and collected survivorship data from the remaining 6%, demonstrating that tracking long-term outcomes is both feasible and worthwhile. The results suggest that one-off grants may have lasting impacts on some types of subsistence firms, challenging the view that sustained engagement is always required.
Circumcision in Australia: prevalence and effects on sexual health

Sir: How can Dr Pattman and colleagues sleep at night knowing there are young Geordies in T-shirts walking around Newcastle with six pus cells or more per highpower field in their urethras? These young men would have been to the new ‘I’m OK’ clinic and are asymptomatics, and would have been told that ‘yes, they have had a full check up and the results are negative’. Surely the wards at Newcastle General will soon fill up with young men suffering from this ‘sixth cell syndrome’ and causing sexual mayhem and destruction on the scene in Newcastle. Now, obviously, I do not want to re-open the whole painful debate on Gram stains and attract more ridicule from our antipodean colleagues, but it does appear to me that gradually the odd head is rising above the parapet claiming that asymptomatic screening clinics work and the wards are not filling up with epididymo-orchitis and pelvic inflammatory disease caused by whatever nebulous organisms are responsible for the ‘sixth cell syndrome’. Of course, we all now accept that some mycoplasmas in some patients are pathogenic and asymptomatic clinics will, on rare occasions, miss this event, with uncertain consequences. However, imminent arrival of NAAT testing for mycoplasma on first-catch urines will possibly generate more problems if found in significant numbers of asymptomatic patients. It looks as if asymptomatic clinics are an absolute necessity in Sexual Health at the moment, particularly, as a significant amount of the choosing health money has simply gone into Primary Care Trust debts. Achieving anything like a 48 -hour access target would be completely impossible without these initiatives. We have obviously embraced this initiative in Chester going one step further, I have to admit, than Newcastle by eliminating even the genital examination, which allows an even faster throughput and opens the potential for less senior personnel to do the clinics. I note also that Newcastle has a similar number of attenders to us who subsequently had to be redirected to a Doctor Clinic (11%), and I would contend that asymptomatic clinics should run simultaneously with a Doctor Clinic or at least have a doctor of some grade available as it gets very unpleasant trying to persuade these patients to re-book for a later date.
An Inference-Based Framework to Manage Data Provenance in Geoscience Applications

Data provenance allows scientists to validate their model as well as to investigate the origin of an unexpected value. Furthermore, it can be used as a replication recipe for output data products. However, capturing provenance requires enormous effort by scientists in terms of time and training. First, they need to design the workflow of the scientific model, i.e., workflow provenance, which requires both time and training. However, in practice, scientists may not document any workflow provenance before the model execution due to the lack of time and training. Second, they need to capture provenance while the model is running, i.e., fine-grained data provenance. Explicit documentation of fine-grained provenance is not feasible because of the massive storage consumption by provenance data in the applications, including those from the geoscience domain where data are continuously arriving and are processed. In this paper, we propose an inference-based framework, which provides both workflow and fine-grained data provenance at a minimal cost in terms of time, training, and disk consumption. Our proposed framework is applicable to any given scientific model, and is capable of handling different model dynamics, such as variation in the processing time as well as input data products arrival pattern. Our evaluation of the framework in a real use case with geospatial data shows that the proposed framework is relevant and suitable for scientists in geoscientific domain.
The necessity of an observational study on the interactions between allergic history and citrus fruit intake for the prevention of pancreatic cancer

While the main product of Jeju Island is citrus fruit and the prevalence of atopic dermatitis among the students who live there is relatively high, the incidence of pancreatic cancer is lowest in Korea. Systematic reviews reporting allergic history and intake of citrus fruit as protective factors against pancreatic cancer (PCC) were published in 2005 and 2008, respectively. Although there were discrepancies in the results of the subgroup analyses between case-control and cohort studies, it is necessary to evaluate an interaction effect between allergic history and intake of citrus fruits on PCC risk.
Which supplementary imaging modality should be used for breast ultrasonography? Comparison of the diagnostic performance of elastography and computer-aided diagnosis

Purpose The aim of this study was to evaluate and compare the diagnostic performance of grayscale ultrasonography (US), US elastography, and US computer-aided diagnosis (US-CAD) in the differential diagnosis of breast masses. Methods A total of 193 breast masses in 175 consecutive women (mean age, 46.4 years) from June to August 2015 were included. US and elastography images were obtained and recorded. A US-CAD system was applied to the grayscale sonograms, which were automatically analyzed and visualized in order to generate a final assessment. The final assessments of breast masses were based on the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) categories, while elasticity scores were assigned using a 5-point scoring system. The diagnostic performance of grayscale US, elastography, and US-CAD was calculated and compared. Results Of the 193 breast masses, 120 (62.2%) were benign and 73 (37.8%) were malignant. Breast masses had significantly higher rates of malignancy in BI-RADS categories 4c and 5, elastography patterns 4 and 5, and when the US-CAD assessment was possibly malignant (all P<0.001). Elastography had higher specificity (40.8%, P=0.042) than grayscale US. US-CAD showed the highest specificity (67.5%), positive predictive value (PPV) (61.4%), accuracy (74.1%), and area under the curve (AUC) (0.762, all P<0.05) among the three diagnostic tools. Conclusion US-CAD had higher values for specificity, PPV, accuracy, and AUC than grayscale US or elastography. Computer-based analysis based on the morphologic features of US may be very useful in improving the diagnostic performance of breast US.