Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of cyclin D1 immunoreactivity and AgNOR staining in the evaluation of benign and malignant lesions of the prostate

Purpose: Prostatic carcinoma is a common and growing public health problem. Histological evaluation is fairly adequate for assessing tumor differentiation, but tumor proliferative activity is difficult to measure. Increasing evidence suggests that the factors controlling cell cycle progression also modulate the rate of ribosome biogenesis. Despite the influence of cyclin D1 and argyrophilic nuclear organizer region (AgNOR) on prostate cancer proliferation, few studies have evaluated the diagnostic importance of these markers. Therefore, the present study was carried out to analyze the diagnostic value of the proliferative markers cyclin D1 and AgNOR in various prostatic lesions and to determine whether any association or relation between these markers and different Gleason grades exists. Methods: A total 50 cases of various prostatic lesions were studied. Tumor grade, AgNOR staining, and cyclin D1 expression were evaluated in all cases. Correlations between the intensity and differential localization of these markers and Gleason grades were evaluated. Results: The mean AgNOR count in cases of prostatic intraepithelial neoplasia was high compared with cases of benign prostatic hyperplasia (BPH) but lower than that of carcinoma cases. The intensity of cyclin D1 expression was high in carcinoma. A total of 14 cases (46.67%) showed strong positivity. No significant correlation was found between the intensity of cyclin D1 expression, AgNOR count, and histologic grades of prostatic carcinoma, whereas a significant correlation was observed between intensity and percentage expression of cyclin D1 in BPH and carcinoma (P<0.01). Nuclear as well as cytoplasmic positivity was seen among various grades of carcinoma. Conclusions: AgNOR count and cyclin D1 may be helpful in distinguishing between BPH and carcinoma of the prostate but may not be used as reliable indicators of the grade of prostatic adenocarcinoma because of overlapping values in various grades. However, further studies on larger samples are required to elucidate the role of these markers in identification of premalignant lesions.
Sense of belonging in cyberspace: Examining the impact of hybrid courses on student persistence

The following is a quantitative study of the effects of hybrid course offerings on student sense of belonging and satisfaction at a commuter campus. The study employed the following independent variables: gender, age, race, class standing, GPA (which was self-reported), marital status, number of children, employment status, number of hours worked per week, number of hybrid courses taken, and 2 dependent variables (sense of belonging and satisfaction). The study found no significant difference in sense of belonging and satisfaction among students in either the hybrid or face-to-face modalities. Other findings found that students with children exhibited a negative relationship between number of children and perceived faculty support/comfort as well as a negative relationship was between number of children and perceived classroom comfort in both hybrid and face-to-face modalities. This study also includes recommendations for additional studies to explore possible interventions to increase students sense of belonging and satisfaction.
BUD22 Affects Ty1 Retrotransposition and Ribosome Biogenesis in Saccharomyces cerevisiae

A variety of cellular factors affect the movement of the retrovirus-like transposon Ty1. To identify genes involved in Ty1 virus-like particle (VLP) function, the level of the major capsid protein (Gag-p45) and its proteolytic precursor (Gag-p49p) was monitored in a subset of Ty1 cofactor mutants. Twenty-nine of 87 mutants contained alterations in the level of Gag; however, only bud22Δ showed a striking defect in Gag processing. BUD22 affected the +1 translational frameshifting event required to express the Pol proteins protease, integrase, and reverse transcriptase. Therefore, it is possible that the bud22Δ mutant may not produce enough functional Ty1 protease to completely process Gag-p49 to p45. Furthermore, BUD22 is required for 18S rRNA processing and 40S subunit biogenesis and influences polysome density. Together our results suggest that BUD22 is involved in a step in ribosome biogenesis that not only affects general translation, but also may alter the frameshifting efficiency of ribosomes, an event central to Ty1 retrotransposition.
COX-2 Inhibitors and Gastric Cancer

The evidence that cyclooxygenase-2 (COX-2) is upregulated and plays an important role in carcinogenesis of gastric cancer has triggered the topic of COX-2 inhibitors as chemopreventive agents for gastric cancer. Studies find that COX-2 inhibitors are associated not only with chemoprophylactic effects, but also with chemotherapeutic potentials in gastric cancer. Both COX-dependent and COX-independent pathways have a role in the anticancer efficiency of COX-2 inhibitors. However, enthusiasm is thwarted by the potential toxicity, that is, gastrointestinal toxicity of nonselective COX-2 inhibitors and cardiovascular risk of selective COX-2 inhibitors. Therefore, more studies are needed to develop new targeted antitumor agents (such as prostaglandin E receptor antagonist) and to define fundamental questions such as optimal treatment regimens, integration of cotherapy, and careful selection of candidates.
Bernoulli catenary and elasto-capillary effect in partially wet fibrous materials

When a wetting liquid wicks into a fibrous material, it causes the material to deform. In this paper we discuss the elasto-capillary effect that leads to spontaneous internal stresses in the materials. The elasto-capillary effect produced by menisci in pores can be identified through a specific stress distribution in the fibrous matrix. We show that the classical Bernoulli problem of a freely hanging fabric can be used for the analysis of gravity-induced stresses in textile materials. These stresses change due to elasto-capillary effect. Wicking of a wetting liquid into a freely suspended fibrous material is shown to be an instructive nontrivial experiment illustrating interesting distinguishable stress distributions in the fibrous matrix.
Open accessibility to information systems research articles

With increasing frequency journal articles are retrieved digitally rather than by obtaining physical printed volumes. This shift to low-cost distribution of research literature has opened up new possibilities for increasing the accessibility and potential readership of published literature. Open Access is a term used to refer to publication of scholarly material without access restrictions, which can be realized either by the publisher directly or indirectly by the author. This paper studies the extent to which information systems research is available Open Access. The results are also contrasted to figures from other areas of science. By sampling journals within the field, systematically looking for free copies through a web search engine, the extent of peer-reviewed IS research was studied. The results indicate that none of the IS journals included in a large citation indexing service covering 18000 journals are fully Open Access, but this is something which is compensated for by authors being quite active in uploading copies of their manuscripts to web sites. There was no significant difference in Open Access patterns between the top journals in the discipline and the rest of the sample. The overall share of Open Access within the field is 21 %.
Effects of curing protocol and storage time on the micro-hardness of resin cements used to lute fiber-reinforced resin posts

Objectives To determine the micro-hardness profile of two dual cure resin cements (RelyX - U100®, 3M-ESPE and Panavia F 2.0®, Kuraray) used for cementing fiber-reinforced resin posts (Fibrekor® - Jeneric Pentron) under three different curing protocols and two water storage times. Material and methods Sixty 16mm long bovine incisor roots were endodontically treated and prepared for cementation of the Fibrekor posts. The cements were mixed as instructed, dispensed in the canal, the posts were seated and the curing performed as follows: a) no light activation; b) light-activation immediately after seating the post, and; c) light-activation delayed 5 minutes after seating the post. The teeth were stored in water and retrieved for analysis after 7 days and 3 months. The roots were longitudinally sectioned and the microhardness was determined at the cervical, middle and apical regions along the cement line. The data was analyzed by the three-way ANOVA test (curing mode, storage time and thirds) for each cement. The Tukey test was used for the post-hoc analysis. Results Light-activation resulted in a significant increase in the microhardness. This was more evident for the cervical region and for the Panavia cement. Storage in water for 3 months caused a reduction of the micro-hardness for both cements. The U100 cement showed less variation in the micro-hardness regardless of the curing protocol and storage time. Conclusions The micro-hardness of the cements was affected by the curing and storage variables and were material-dependent.
Invitation to data reduction and problem kernelization

To solve NP-hard problems, polynomial-time preprocessing is a natural and promising approach. Preprocessing is based on data reduction techniques that take a problem's input instance and try to perform a reduction to a smaller, equivalent problem kernel. Problem kernelization is a methodology that is rooted in parameterized computational complexity. In this brief survey, we present data reduction and problem kernelization as a promising research field for algorithm and complexity theory.
The board president’s role in controlling the decision-making process in voluntary sports organizations

The goal of the study is to understand the president´s influence and his skills in the strategic decision-making process. The qualitative nature of the study implied a participant’s observation during board meetings (with a total of 35 sports directors - 3 professionals and 32 volunteers), as well as interviewing the six board presidents of the sports associations that are part of the study. The main results revealed a poorly structured decision-making process, but with a determinant role of the board president in the conduction and manipulation of the said process. This was especially evident with the professional sports directors who showed higher knowledge and better preparation of the subjects. Likewise, both of the associations headed by full-time professional sports directors, along with an association led by a volunteer sports director (though strongly backed by the technical director of sport or sports manager during the meetings and decision-making), revealed greater strategic management and better organizational results. The main power sources of the board president, and the skills he uses in order to mark the decision’s direction are internal alliances with the closest sports director (volunteer and professional), anticipation through a previous expressed opinion, the use of information, sports expertise, and also the knowledge regarding the existent problems among the clubs and the affiliated coaches. The results found bad governance which shows confusing and poorly structured management practices. This study intents to contribute for the change of the relationship between the role of the board and the technical director of sport or sport manager (specially for the relevance of the last), in order to improve better strategic decision-making in the non-profit sport organizations.
Evaluation of the Hemodynamic Response to Endotracheal Intubation Comparing the Airtraq® with Macintosh Laryngoscopes in Cardiac Surgical Patients

Introduction: Cardiac patients are more prone to develop hemodynamic instability on induction of anesthesia and endotracheal intubation. The Airtraq® optical laryngoscope is a single-use rigid video laryngoscope that has been developed to facilitate tracheal intubation. There are limited studies comparing differences in the circulatory responses to Airtraq® and direct Macintosh larynngoscopy in cardiac patients. Aim: The purpose of our study was to evaluate whether there was clinically significant difference between the hemodynamic response to orotracheal intubation guided by either of the two devices (Airtraq® and Macintosh laryngoscopes) in patients who underwent coronary artery bypass grafting surgery. Material and methods: In this clinical study we analyzed the hemodynamic response to endotracheal intubation performed with Airtraq® or Macintosh laryngoscopes in patients who underwent elective coronary artery bypass graft surgery under general anesthesia. Results: We analyzed: blood pressure (systolic, diastolic, mean), heart rate and peripheral oxygen saturation (all notified before induction in anesthesia, immediately after induction, at the time of intubation and thereafter one and five minutes after intubation). We also recorded the maximal values of blood pressure and heart rate, as well as calculated the product of heart rate and systolic blood pressure. There were statistically significant differences in the hemodynamic response between the groups. At the time of intubation, there was significant inter-group difference in heart rate, systolic, diastolic and mean blood pressure. Endotracheal intubation with Macintosh laryngoscope was accompanied by significant increase in blood pressure and heart rate compared to Airtraq® group. Conclusion: The Airtraq® laryngoscope performed better than the Macintosh laryngoscope in terms of hemodynamic to the patient undergoing routine coronary artery bypass graft surgery.
Contact-Free Heart Rate Measurement Using a Camera

In this paper, a contact-free heart rate measurement method using an ambient light camera is proposed. The color features of skin-like pixels are used for time domain frequency analysis, in which a skin color classifier is applied. A novel data adjustment scheme is further integrated to automatically expand sampling time length and increase measurement precision. Five people of different age, six cameras of different type, and four different body parts have been tested in this paper. Experimental results show the effectiveness of the proposed method comparing with a pulse oximeter device. The advantages of the proposed method include: 1) it uses a low-cost ambient light camera, 2) it eases the discomfort of people based on contact-free methodology, 3) it measures multiple persons' heart rates fully automatic, and 4) it can be applied in multiple parts of a human body such as head and neck, arm, and palm regions.
Between Verbalization and Reflection: Referential Activity and Narrative Processes in Borderline Personality Organization

Both empirical and theoretical data would seem to suggest that patients with borderline personality organization (BPO; e.g., O. F. Kernberg, 2004b) show severe problems with emotional regulation that arise due to dysfunctions in intrapsychic representation and emotional–relational processing. The research presented here examines emotional–relational processing from 2 points of view—from that of referential activity (RA) and through the process of narrative processing. A major goal of the 2 presented studies was to explore the referential and narrative processes in BPO. Study 1 compares BPO with a general group of higher personality organization, Study 2 with specified groups (neurotic personality organization [NPO] and integrated personality organization [IPO]). We hypothesized that people with BPO (in their utterances) would show lower emotional–relational processing that might manifest in higher RA processes. The RA indices (concreteness, specificity, and imagery) were significantly higher in the BPO group for narratives about negative emotional–relational situations. No intergroup differences were observed for narratives about positive emotional–relational conditions (Study 1). Moreover, when lexical indices were used, the concreteness index was higher in a statistically significant way for BPO, in comparison with NPO, and the imagery index was significantly higher in BPO than in the IPO group (Study 2). From the experience-processing point of view, results in the BPO group revealed verbal access to emotional experiences but without the reflection stage, where arousal would have connected to meaning. Taking the structure of the representation into account, the disturbance in emotional–relational processing might be explained by a splitting within the intrapsychic representation.
FOCUS: enhancing children's engagement in reading by using contextual BCI training sessions

Reading is an important aspect of a child's development. Reading outcome is heavily dependent on the level of engagement while reading. In this paper, we present FOCUS, an EEG-augmented reading system which monitors a child's engagement level in real time, and provides contextual BCI training sessions to improve a child's reading engagement. A laboratory experiment was conducted to assess the validity of the system. Results showed that FOCUS could significantly improve engagement in terms of both EEG-based measurement and teachers' subjective measure on the reading outcome.
Magnetofection Enhances Adenoviral Vector-based Gene Delivery in Skeletal Muscle Cells

The goal of magnetic field-assisted gene transfer is to enhance internalization of exogenous nucleic acids by association with magnetic nanoparticles (MNPs). This technique named magnetofection is particularly useful in difficult-to-transfect cells. It is well known that human, mouse, and rat skeletal muscle cells suffer a maturation-dependent loss of susceptibility to Recombinant Adenoviral vector (RAd) uptake. In postnatal, fully differentiated myofibers, the expression of the primary Coxsackie and Adenoviral membrane receptor (CAR) is severely downregulated representing a main hurdle for the use of these vectors in gene transfer/therapy. Here we demonstrate that assembling of Recombinant Adenoviral vectors with suitable iron oxide MNPs into magneto-adenovectors (RAd-MNP) and further exposure to a gradient magnetic field enables to efficiently overcome transduction resistance in skeletal muscle cells. Expression of Green Fluorescent Protein and Insulin-like Growth Factor 1 was significantly enhanced after magnetofection with RAd-MNPs complexes in C2C12 myotubes in vitro and mouse skeletal muscle in vivo when compared to transduction with naked virus. These results provide evidence that magnetofection, mainly due to its membrane-receptor independent mechanism, constitutes a simple and effective alternative to current methods for gene transfer into traditionally hard-to-transfect biological models.
Comparison of Athletes’ Proneness to Depressive Symptoms in Individual and Team Sports: Research on Psychological Mediators in Junior Elite Athletes

Depression among elite athletes is a topic of increasing interest and public awareness. Currently, empirical data on elite athletes’ depressive symptoms are rare. Recent results indicate sport-related mechanisms and effects on depression prevalence in elite athlete samples; specific factors associated with depression include overtraining, injury, and failure in competition. One such effect is that athletes competing in individual sports were found to be more prone to depressive symptoms than athletes competing in team sports. The present study examined this effect by testing three possible, psychological mediators based on theoretical and empirical assumptions: namely, cohesion in team or training groups; perception of perfectionistic expectations from others; and negative attribution after failure. In a cross-sectional study, 199 German junior elite athletes (Mage = 14.96; SD = 1.56) participated and completed questionnaires on perfectionism, cohesion, attribution after failure, and depressive symptoms. Mediation analysis using path analysis with bootstrapping was used for data analysis. As expected, athletes in individual sports showed higher scores in depression than athletes in team sports [t(197) = 2.05; p < 0.05; d = 0.30]. Furthermore, negative attribution after failure was associated with individual sports (β = 0.27; p < 0.001), as well as with the dependent variable depression (β = 0.26; p < 0.01). Mediation hypothesis was supported by a significant indirect effect (β = 0.07; p < 0.05). Negative attribution after failure mediated the relationship between individual sports and depression scores. Neither cohesion nor perfectionism met essential criteria to serve as mediators: cohesion was not elevated in either team or individual sports, and perfectionism was positively related to team sports. The results support the assumption of previous findings on sport-specific mechanisms (here the effect between individual and team sports) contributing to depressive symptoms among elite athletes. Additionally, attribution after failure seems to play an important role in this regard and could be considered in further research and practitioners in the field of sport psychology.
Minimalism and bilingualism: How and why bilingualism could benefit children with SLI*

We begin with the hypothesis that all people are “bilingual” because every language contains ingredients from several grammars, just as English exhibits both an Anglo-Saxon and a Latinate vocabulary system. We argue that the dominant grammar is defined by productivity and recursion in particular. Although current evidence is sparse, in principle, for a child who shows Specific Language Impairment (SLI) in a bilingual environment, richer modules in one grammar may help trigger more obscure modules in another language. Thus, if one language has a rich case system, it may help a child see an impoverished case system in another grammar. Examples from prepositional systems, wh-movement, recursive possessives and others are discussed. In general, a second language can be beneficial to the SLI child in the acquisition of both languages. Minimalism offers a level of abstraction where these cross-language connections can most naturally be stated.
Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis

Objective. To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. Methods. A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nondiabetic adults. Results. A total of nine eligible studies with twelve comparisons were included for the final meta-analysis. Circulating betatrophin levels in T2DM patients were higher than those in the nondiabetic controls (random-effect SMD 0.53; 95% CI 0.13 to 0.94; P = 0.010). In the subgroup of nonobese population but not the obese population, the overall betatrophin level in T2DM patients was much higher than that in the nondiabetic controls (nonobese: random-effect SMD, 0.82; 95% CI 0.42 to 1.21; P < 0.001; obese: random-effect SMD, −0.39; 95% CI, −0.95 to 0.18; P = 0.18). Metaregression indicated that body mass index of T2DM patients was associated with mean difference of betatrophin level between T2DM and nondiabetic adults (slope, −578.8; t = −2.7; P = 0.02). Conclusion. Based on the findings of our meta-analysis, circulating betatrophin level of T2DM patients is higher than that of nondiabetic adults in the nonobese population, but not in the obese population.