Miracle-dz/UniFAR-FTUs huggingface dataset:
Multigroup Construct Validity Evidence of the HOPE Scale: Instrumentation to Identify Low-Income Elementary Students for Gifted Programs

Students with exceptional academic potential who come from low-income families are frequently not identified for and consequently are underrepresented in gifted and talented programs. Because of this, new means of identifying such children must be developed. This article presents the findings of exploratory and confirmatory factor analyses conducted on the HOPE Scale, a 13-item teacher-rating instrument designed to identify academic and social components of giftedness in elementary-aged students. Participants included 349 teachers who completed HOPE Scales on 5,995 ethnically and economically diverse students from three rural and two metropolitan school districts in the Midwest. Multigroup confirmatory factor analysis was also used to evaluate measurement invariance between income groups. Findings suggest a two-factor model represents good fit for the data while remaining loyal to the latent constructs of academic and social giftedness. Although showing some legitimate mean differences, invariance test results suggested equivalence of model form, factor loading, and factor variances across income groups. Putting the Research to Use This research has important implications for practice. Frequently, traditional measures of achievement or aptitude under-identify children from low-income families. Concerns exist about the usefulness of teacher-ratings forms or scales in gifted and talented student identification. However, when given specific items or descriptors, teachers can provide useful information concerning student performance. The HOPE Scale provides items that teachers can use to rate specific social and academic behaviors of their students. Findings from this study revealed that teaches can effectively nominate low-income students for gifted programs. Further, items on the HOPE Scale were not biased against low-income students as rated by their teachers, meaning that the social and academic scales provided similar information concerning students in either income group. However, mean scores for student from low-income families on both scales were lower than their non-low income peers, providing evidence that instruments need to be normed on the specific groups for which their use is intended. Practitioners, should not shy away from using teacher nomination instruments, but they should consider the psychometric information available concerning the use of these instruments or rating forms as used with students in demographic groups of intended use. The HOPE Scale, as developed with indicated revisions, will provide educators and researchers with a simple, psychometrically sound instrument to help with identification of underrepresented student for gifted education services.
Methylene blue reduces pulmonary oedema and cyclo-oxygenase products in endotoxaemic sheep

The authors recently demonstrated that methylene blue (MB), an inhibitor of the nitric oxide (NO) pathway, reduces the increments in pulmonary capillary pressure, lung lymph flow and protein clearance in endotoxaemic sheep. In the present study, the authors examined whether MB influences pulmonary haemodynamics and accumulation of extravascular lung water (EVLW) by mechanisms other than the NO pathway. Sixteen awake, chronically-instrumented sheep randomly received either an intravenous injection of MB 10 mg·kg−1 or isotonic saline. Thirty minutes later, all sheep received an intravenous infusion of Escherichia coli endotoxin 1 µg·kg−1 for 20 min and either an intravenous infusion of MB 2.5 mg·kg−1·h−1 or isotonic saline for 6 h. MB markedly attenuated the endotoxin-induced pulmonary hypertension and right ventricular failure, and reduced the accumulation of EVLW. Moreover, MB reduced the increments in plasma thromboxane B2 and 6-keto-prostaglandin F1α, and abolished the febrile response. However, MB had no effect on the changes in circulating neutrophils, serum hyaluronan, and total haemolytic activity of the alternative complement pathway. The authors conclude that in sheep, methylene blue attenuates the endotoxin-induced pulmonary hypertension and oedema, at least in part, by inhibiting the cyclo-oxygenase products of arachidonic acid. This is a novel effect of methylene blue in vivo.
The Process Mechanisms Linking Recruiter Positive Moods and Organizational Attraction

The main purpose of this study is to investigate the mechanisms through which recruiters' positive moods lead to organizational attraction. Participants consisted of 161 applicant–recruiter dyads from 55 companies in Taiwan. Results show that recruiters' felt positive moods were positively related to applicant's perceptions of informativeness and competence, which, in turn, influenced organizational attraction. In addition, recruiters felt that positive moods were positively related to their display of positive moods, which were positively related to applicant's positive moods, which, in turn, affected organizational attraction.
Modeling the Antecedents of Co-Production Behavior in Virtual Communities

This study pursues a better understanding of member co-production behavior in virtual communities. To extend prior research, it proposes and tests a model with three levels of behavioral antecedents. The authors test this model using both self-reported and objective behavioral data. With the exception of perceived member support, each proposed antecedent significantly influences co-production behavior through different processes. Informativeness and recognition of contribution significantly influence co-production behavior through satisfaction, community prestige affects it through identification, and enjoyment exerts the greatest effect through both satisfaction and identification. The authors conclude by considering some managerial and research implications of the study’s findings.
Exploring the optimal chunk selection policy for data-driven P2P streaming systems

Data-driven P2P streaming systems can potentially provide good playback rate to a large number of viewers. One important design problem in such P2P systems is to determine the optimal chunk selection policy that provides high continuity playback under the server's upload capacity constraint. We present a general and unified mathematical framework to analyze a large class of chunk selection policies. The analytical framework is asymptotically exact when the number of viewers is large. More importantly, we provide some interesting observations on the optimal chunk selection policy: it is of shaped and becomesmore greedy as the upload capacity of the server increases. This insight helps content providers to deploy large scale streaming systems with a QoS-guarantee under a given cost constraint.
Apple procyanidins decrease cholesterol esterification and lipoprotein secretion in Caco-2/TC7 enterocytes Published, JLR Papers in Press, December 1, 2004. DOI 10.1194/jlr.M400209-JLR200

Decrease of plasma lipid levels by polyphenols was linked to impairment of hepatic lipoprotein secretion. However, the intestine is the first epithelium that faces dietary compounds, and it contributes to lipid homeostasis by secreting triglyceride-rich lipoproteins during the postprandial state. The purpose of this study was to examine the effect of apple and wine polyphenol extracts on lipoprotein synthesis and secretion in human Caco-2/TC7 enterocytes apically supplied with complex lipid micelles. Our results clearly demonstrate that apple, but not wine, polyphenol extract dose-dependently decreases the esterification of cholesterol and the enterocyte secretion of lipoproteins. Apple polyphenols decrease apolipoprotein B (apoB) secretion by inhibiting apoB synthesis without increasing the degradation of the newly synthesized protein. Under our conditions, cholesterol uptake, apoB mRNA, and microsomal triglyceride protein activity were not modified by apple polyphenols. The main monomers present in our mixture did not interfere with the intestinal lipid metabolism. By contrast, apple procyanidins reproduced the inhibition of both cholesteryl ester synthesis and lipoprotein secretion. Overall, our results are compatible with a mechanism of action of polyphenols resulting in impaired lipid availability that could induce the inhibition of intestinal lipoprotein secretion and contribute to the hypolipidemic effect of these compounds in vivo.
How Effective Teachers Differentiate Instruction and Interact With Students Who Engage in Off-task Behaviours in the Classroom

The purpose of this study was to discover and describe how two teachers effectively interacted with and differentiated instruction for students who displayed offtask behaviors in the classroom. Through the use of observations and interviews, I described how two teachers interacted with students who display high-frequency, lowintensity off-task behaviors; identified strategies these effective teachers used in dealing with these behaviors; described where the teachers’ behaviours, attitudes, and practices lay on the Preventive-Restorative (P-R) continuum of beliefs of inclusion; and discovered how the teachers’ self-efficacy is related to P-R orientations and effective teaching behaviors. The teachers were chosen based on their principals’ belief in their effectiveness in dealing with off-task behaviours. The principal and the teacher collaboratively chose the students who displayed off-task behaviours on a consistent basis. The findings of this study confirm the existing research; the two teachers, whose beliefs lay on the preventive end of the continuum of beliefs of inclusion, tended to use effective teaching practices; these beliefs and practices were related to the teachers’ beliefs of their capability in being able to effectively help their students; these two teachers, who have preventive beliefs and high efficacy beliefs, interact in ways that are beneficial to students who display offtask behaviours. The common themes that emerged through the analysis of both teachers’ data included the belief in and the use of differentiated instruction; the belief in the importance of having a positive classroom environment; the practice of ensuring student engagement; the teachers’ use of their knowledge about students; and the teachers’ beliefs about
Aca1 and Aca2, ATF/CREB Activators in Saccharomyces cerevisiae, Are Important for Carbon Source Utilization but Not the Response to Stress

ABSTRACT In Saccharomyces cerevisiae, the family of ATF/CREB transcriptional regulators consists of a repressor, Acr1 (Sko1), and two activators, Aca1 and Aca2. The AP-1 factor Gen4 does not activate transcription through ATF/CREB sites in vivo even though it binds these sites in vitro. Unlike ATF/CREB activators in other species, Aca1- and Aca2-dependent transcription is not affected by protein kinase A or by stress, and Aca1 and Aca2 are not required for Hog1-dependent salt induction of transcription through an optimal ATF/CREB site. Aca2 is important for a variety of biological functions including growth on nonoptimal carbon sources, and Aca2-dependent activation is modestly regulated by carbon source. Strains lacking Aca1 are phenotypically normal, but overexpression of Aca1 suppresses some defects associated with the loss of Aca2, indicating a functional overlap between Aca1 and Aca2. Acr1 represses transcription both by recruiting the Cyc8-Tup1 corepressor and by directly competing with Aca1 and Aca2 for target sites. Acr1 does not fully account for osmotic regulation through ATF/CREB sites, and a novel Hog1-dependent activator(s) that is not a bZIP protein is required for ATF/CREB site activation in response to high salt. In addition, Acr1 does not affect a number of phenotypes that arise from loss of Aca2. Thus, members of the S. cerevisiae ATF/CREB family have overlapping, but distinct, biological functions and target genes.
Reinventing Academic Publishing Online. Part I: Rigor, Relevance and Practice

While current computing practice abounds with innovations like online auctions, blogs, wikis, twitter, social networks and online social games, few if any genuinely new theories have taken root in the corresponding “top” academic journals. Those creating computing progress increasingly see these journals as unreadable, outdated and irrelevant. Yet as technology practice creates, technology theory is if anything becoming even more conforming and less relevant. We attribute this to the erroneous assumption that research rigor is excellence, a myth contradicted by the scientific method itself. Excess rigor supports the demands of appointment, grant and promotion committees, but is drying up the wells of academic inspiration. Part I of this paper chronicles the inevitable limits of what can only be called a feudal academic knowledge exchange system, with trends like exclusivity, slowness, narrowness, conservatism, self-involvement and inaccessibility. We predict an upcoming social upheaval in academic publishing as it shifts from a feudal to democratic form, from knowledge managed by the few to knowledge managed by the many. The technology trigger is socio-technical advances. The drive will be that only democratic knowledge exchange can scale up to support the breadth, speed and flexibility modern cross-disciplinary research needs. Part II suggests the sort of socio-technical design needed to bring this transformation about.
Global human rights governance and orchestration: National human rights institutions as intermediaries

The United Nations remains the principal international governmental organisation for promoting human rights. However, serious concerns focus on persistent compliance gaps between human rights standards and domestic practice. In response and against a backdrop of growing regime complexity, United Nations human rights agencies have increasingly sought to bypass states by coordinating new forms of non-state and private authority. International Relations scholarship has captured this governance arrangement using the concept of orchestration, defined as when an international organisation enlists and supports intermediary actors to address target actors in pursuit of international governmental organisation governance goals. This article explores the implications of an orchestration topology for human rights governance by analysing national human rights institutions in the context of an established global human rights regime and its dedicated orchestrator: the Office of the High Commissioner for Human Rights. I use the experience of national human rights institutions to further refine the concepts of managing versus bypassing states to capture how networked intermediaries are affected by, and respond to, new opportunities within international governmental organisation structures. The article identifies the conditions under which orchestration may be particularly well-suited to a human rights governance function. It further examines the analytical limitations of this mode of influence for addressing a multi-level compliance gap, as well as what the analysis means for international organisations and understanding orchestration more generally.
Caspase-8 Activation Precedes Alterations of Mitochondrial Membrane Potential during Monocyte Apoptosis Induced by Phagocytosis and Killing of Staphylococcus aureus

ABSTRACT Human peripheral blood monocytes become apoptotic following phagocytosis and killing of Staphylococcus aureus. Although this type of monocyte apoptosis is known to be initiated by Fas-Fas ligand (FasL) interactions, the downstream signaling pathway has not been determined. In this work the involvement of mitochondria and the kinetics of caspase-8 and caspase-3 activation after phagocytosis of S. aureus were studied. Caspase-8 activity was measured in cell lysates by using the fluorogenic substrate Ac-IETD-AFC. Active caspase-3 levels and mitochondrial membrane potential (Δψm) were measured in whole cells by flow cytometry using monoclonal antibodies reacting with activated caspase-3 and chloromethyl-X-rosamine, respectively. The results show that caspase-8 was activated shortly after phagocytosis of bacteria. Caspase-8 activation was followed by progressive disruption of Δψm, which is associated with the production of reactive oxygen intermediates. The irreversible caspase-8 inhibitor zIETD-FMK prevented the disruption of Δψm and the release of cytochrome c from S. aureus-exposed monocytes. Caspase-3 activation occurred following disruption of Δψm. These results strongly suggest that apoptosis of monocytes that have phagocytosed and killed S. aureus is driven by the Fas-FasL-initiated pathway, which is typical for type II cells.
Academic Librarians Use Evidence for Convincing

The objective of this study was to explore and understand how academic librarians use evidence in their professional decision making. A grounded theory methodology was used, following the approach of Charmaz. The 19 participants were academic librarians in Canada. Data were gathered via online diaries and semistructured interviews over a 6-month period in 2011. The findings from this study illustrate how academic librarians use evidence in their practice, namely to convince. Convincing has two subcategories: confirming, which is usually applied to oneself, and influencing, which is usually applied to others. This study is the first to focus on how academic librarians use evidence in their decision making. The findings highlight the impact of collaboration and organizational dynamics on decision making and evidence use. Convincing emerged as the main theoretical concept in relation to how evidence is used.
Association of 677 C>T (rs1801133) and 1298 A>C (rs1801131) Polymorphisms in the MTHFR Gene and Breast Cancer Susceptibility: A Meta-Analysis Based on 57 Individual Studies

Objective The 677 C>T and 1298 A>C polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene have been widely reported and considered to have a significant effect on breast cancer risk, but the results are inconsistent. A meta-analysis based on 57 eligible studies was carried out to clarify the role of MTHFR gene polymorphisms in breast cancer. Methods and Results Eligible articles were identified by searching databases including PubMed, Web of Science, EMBASE, CNKI and CBM for the period up to August 2012. Finally, a total of 57 studies were included in this meta-analysis. Crude ORs with 95% CIs were used to assess the association between the MTHFR polymorphisms and breast cancer risk. The pooled ORs were performed with additive model, dominant model and recessive model, respectively. Subgroup analysis was also performed by ethnicity. The statistical heterogeneity across studies was examined with χ2-based Q-test. A meta-analysis was performed using the Stata 12.0 software. Overall, the 677 C allele was significantly associated with breast cancer risk (OR = 0.942, 95%CI = 0.898 to 0.988) when compared with the 677 T allele in the additive model, and the same results were also revealed under other genetic models. Simultaneously, the 1298 A allele was not associated with the breast cancer susceptibility when compared with the 1298 C allele (OR = 0.993, 95%CI = 0.978 to 1.009). Furthermore, analyses under the dominant, recessive and the allele contrast model yielded similar results. Conclusions The results of this meta-analysis suggest that 677 C>T polymorphism in the MTHFR gene may contribute to breast cancer development. However, the 1298 A>C polymorphism is not significantly associated with increased risks of breast cancer.
Circulating Anti-Wild-Type Adeno-Associated Virus Type 2 (AAV2) Antibodies Inhibit Recombinant AAV2 (rAAV2)-Mediated, but Not rAAV5-Mediated, Gene Transfer in the Brain

ABSTRACT Epidemiological studies report that 80% of the population maintains antibodies (Ab) to wild-type (wt) adeno-associated virus type 2 (AAV2), with 30% expressing neutralizing Ab (NAb). The blood-brain barrier (BBB) provides limited immune privilege to brain parenchyma, and the immune response to recombinant AAV (rAAV) administration in the brain of a naive animal is minimal. However, central nervous system transduction in preimmunized animals remains unstudied. Vector administration may disrupt the BBB sufficiently to promote an immune response in a previously immunized animal. We tested the hypothesis that intracerebral rAAV administration and readministration would not be affected by the presence of circulating Ab to wt AAV2. Rats peripherally immunized with live wt AAV2 and naive controls were tested with single intrastriatal injections of rAAV2 encoding human glial cell line-derived neurotrophic factor (GDNF) or green fluorescent protein (GFP). Striatal readministration of rAAV2-GDNF was also tested in preimmunized and naive rats. Finally, serotype specificity of the immunization against wt AAV2 was examined by single injections of rAAV5-GFP. Preimmunization resulted in high levels of circulating NAb and prevented transduction by rAAV2 as assessed by striatal GDNF levels. rAAV2-GFP striatal transduction was also prevented by immunization, while rAAV5-GFP-mediated transduction, as assessed by stereological cell counting, was unaffected. Additionally, inflammatory markers were present in those animals that received repeated administrations of rAAV2, including markers of a cell-mediated immune response and cytotoxic damage. A live virus immunization protocol generated the circulating anti-wt-AAV Ab seen in this experiment, while human titers are commonly acquired via natural infection. Regardless, the data show that the presence of high levels of NAb against wt AAV can reduce rAAV-mediated transduction in the brain and should be accounted for in future experiments utilizing this vector.
The ESCRT machinery is not required for human cytomegalovirus envelopment

The human cytomegalovirus (HCMV) has been proposed to complete its final envelopment on cytoplasmic membranes prior to its release to the extracellular medium. The nature of these membranes and the mechanisms involved in virus envelopment and release are poorly understood. Here we show by immunogold‐labelling and electron microscopy that CD63, a marker of multivesicular bodies (MVBs), is incorporated into the viral envelope, supporting the notion that HCMV uses endocytic membranes for its envelopment. We therefore investigated a possible role for the cellular endosomal sorting complex required for transport (ESCRT) machinery in HCMV envelopment. Depletion of tumour suppressor gene 101 and ALIX/AIP1 with small interfering RNAs (siRNAs) in HCMV‐infected cells did not affect virus production. In contrast, siRNAs against the vacuolar protein sorting 4 (VPS4) proteins silenced the expression of VPS4A and VPS4B, inhibited the sorting of epidermal growth factor to lysosomes, the formation of HIV Gag‐derived virus‐like particles and vesicular stomatitis virus infection, but enhanced the number of HCMV viral particles produced. Treatment of infected cells with protease inhibitors also increased viral production. These studies indicate that, in contrast to some enveloped RNA viruses, HCMV does not require the cellular ESCRT machinery to complete its envelopment.