Miracle-dz/UniFAR-FTUs huggingface dataset:
Distributing Coalitional Value Calculations among Cooperative Agents

The process of forming coalitions of software agents generally requires calculating a value for every possible coalition which indicates how beneficial that coalition would be if it was formed. Now, since the number of possible coalitions increases exponentially with the number of agents involved, having one agent calculate all the values is inefficient. Given this, we present a novel algorithm for distributing this calculation among agents in cooperative environments. Specifically, by using our algorithm, each agent is assigned some part of the calculation such that the agents' shares are exhaustive and disjoint. Moreover, the algorithm is decentralized, requires no communication between the agents, and has minimal memory requirements. To evaluate the effectiveness of our algorithm we compare it with the only other algorithm available in the literature (due to Shehory and Kraus). This shows that for the case of 25 agents, the distribution process of our algorithm took 0.00037% of the time, the values were calculated using 0.000006% of the memory, the calculation redundancy was reduced from 477826101 to 0, and the total number of bytes sent between the agents dropped from 674047872 to 0 (note that for larger numbers of agents, these improvements become exponentially better).
HIGH-REDSHIFT GALAXIES IN THE HUBBLE DEEP FIELD : COLOUR SELECTION AND STAR FORMATION HISTORY TO Z 4

The Lyman decrement associated with the cumulative effect of H I in QSO absorption systems along the line of sight provides a distinctive feature for identifying galaxies at z ≳ 2.5. Colour criteria, which are sensitive to the presence of a Lyman continuum break superposed on an otherwise flat UV spectrum, have been shown, through Keck spectroscopy, to successfully identify a substantial population of star-forming galaxies at 3 ≲ z ≲ 3.5. Such objects have proven to be surprisingly elusive in field galaxy redshift surveys; quantification of their surface densities and morphologies is crucial for determining how and when galaxies formed. The Hubble Deep Field (HDF) observations offer the opportunity to exploit the ubiquitous effect of intergalactic absorption and obtain useful statistical constraints on the redshift distribution of galaxies to considerably fainter limits than the current spectroscopic limits. We model the H I cosmic opacity as a function of redshift, including scattering in resonant lines of the Lyman series and Lyman continuum absorption, and use stellar population synthesis models with a wide variety of ages, metallicities, dust contents and redshifts to derive colour selection criteria that provide a robust separation between high-redshift and low-redshift galaxies. From the HDF images we construct a sample of star-forming galaxies at 2 ≲z ≲ 4.5. While none of the ∼ 60 objects in the HDF having known Keck/Low-Resolution Imaging Spectrograph (LRIS) spectroscopic redshifts in the range 0 ≲ z ≲1.4 is found to contaminate our high-redshift sample, our colour criteria are able to efficiently select the 2.6 ≲ z ≲ 3.2 galaxies identified by Steidel et al. The ultraviolet (and blue) dropout technique opens up the possibility of investigating cosmic star and element formation in the early Universe. We set a lower limit to the ejection rate of heavy elements per unit comoving volume from Type II supernovae at 〈z〉 = 2.75 of ≈ 3.6 × 10^(−4) M_⊙ yr^(−1) Mpc^(−3) (for q_0 = 0.5 and H_0 = 50 km s^(−1) Mpc^(−1)), which is 3 times higher than the local value but still 4 times lower than the rate observed at z ≈ 1. At 〈z〉 = 4, our lower limit to the cosmic metal ejection rate is ≈ 3 times lower than the 〈z〉 = 2.75 value. We discuss the implications of these results on models of galaxy formation, and on the chemical enrichment and ionization history of the intergalactic medium.
Hematocrit, Anemia, and Arm Preference for Blood Sample Collection: A Cross-Sectional Study of Pregnant Women in Enugu, South-Eastern, Nigeria

Background: Anemia in pregnancy is a common cause of maternal morbidity and mortality in developing countries. Regular review of hematocrit (HCT) and anemia patterns in pregnancy is necessary in our environment. Aim: The aim was to determine the average HCT, prevalence, and pattern of anemia, as well the arm preferences for blood sample collection among pregnant women in Enugu, South East Nigeria. Subjects and Methods: HCT was determined using venous blood of 200 antenatal women at the University of Nigeria Teaching Hospital (UNTH) Enugu, Nigeria. Questionnaires were used to assess participants′ arm preference for blood sample collection for clinical investigations. Data analysis was descriptive and inferential at 95% confidence level. Results: Participants′ mean HCT was 33.3 (3.7%). The average HCT in second trimester 33.3% (3.76%) was significantly lower than that of third trimester (34.6 [3.4%], P = 0.01,). Prevalence of anemia was 28.0% (56/200), and a majority (94.6%, 53/56) of anemic women belong to the mild category. Only parity groups had a significant association with anemia in pregnancy (P = 0.04). None of the participants reported being asked about her arm preference during blood collection for routine antenatal investigations. One hundred and five (52.5%) women expressed preference for either left (34.5%, 69/200) or right arm (18.0%, 36/200) for blood sample collection. Conclusion: The average HCT among pregnant women at the UNTH, Enugu Nigeria was within normal range and the prevalence of anemia was relatively low. The majority of women expressed a preference for either right or left arm for blood sample collection for clinical investigations and would wish their choices sought for and respected.
Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections

There are no currently approved treatments for filovirus infections. In this study we report the discovery process which led to the development of antisense Phosphorodiamidate Morpholino Oligomers (PMOs) AVI-6002 (composed of AVI-7357 and AVI-7539) and AVI-6003 (composed of AVI-7287 and AVI-7288) targeting Ebola virus and Marburg virus respectively. The discovery process involved identification of optimal transcript binding sites for PMO based RNA-therapeutics followed by screening for effective viral gene target in mouse and guinea pig models utilizing adapted viral isolates. An evolution of chemical modifications were tested, beginning with simple Phosphorodiamidate Morpholino Oligomers (PMO) transitioning to cell penetrating peptide conjugated PMOs (PPMO) and ending with PMOplus containing a limited number of positively charged linkages in the PMO structure. The initial lead compounds were combinations of two agents targeting separate genes. In the final analysis, a single agent for treatment of each virus was selected, AVI-7537 targeting the VP24 gene of Ebola virus and AVI-7288 targeting NP of Marburg virus, and are now progressing into late stage clinical development as the optimal therapeutic candidates.
Superior and anterior inferior cerebellar arteries and their relationship with cerebello-pontine angle cranial nerves revisited in the light of cranial cephalometric indexes: a cadaveric study.

AIM The aim was to clarify the anatomical features of the superior and anterior inferior cerebellar arteries in relation to the trigeminal nerve and acoustic-facial complex and to the bony structures of the skull in a sample of male Iranian cadavers. MATERIAL AND METHODS Bilateral dissections, calvariectomy, and brain evacuation were performed on 31 adult human fresh brains and skull bases to assess the neurovascular associations, and skull base morphometry. Equations were defined to estimate posterior fossa volume and the relationships between bony and neurovascular elements. RESULTS Eight SCAs were duplicated from origin. There were 9 cases of SCA-trigeminal contacts, which were at the root entry zone in 7. Mean distance from the origin of AICA to the vertebrobasilar junction was 11.80 mm, while 79% of AICAs originated from the lower half of the BA. This was significantly associated with "posterior fossa funneling" and "basilar narrowing" indexes. In most cases AICA crossed the acoustic-facial complex and coursed between neural bundles (48.3%). The AICA reached or entered the internal acoustic canal in 22.6% of cases and was medial to porous in 77.4%. CONCLUSION We documented anatomical variations of the superior and anterior inferior cerebellar arteries along with some cephalometric equations with relevant neurovascular anatomy in Iranian cadavers.
Predictive value of allergy tests for neuromuscular blocking agents: tackling an unmet need

Neuromuscular blocking agents (NMBAs) are a predominant cause of perioperative anaphylaxis in Europe. Diagnosis of NMBA allergy relies upon the careful review of the anaesthetic report complemented with skin tests. Additional diagnostic tests are quantification of specific IgE antibodies (sIgE) and basophil activation test (BAT). However, data on the predictive value of the skin tests, the BAT and the sIgE assays (drug‐specific and substituted ammonium structures) are limited or not available, mainly because such exploration requires dangerous NMBA provocation tests.
FlashPatch: Spreading Software Updates over Flash Drives in Under-connected Regions

Computers in developing regions often lack the Internet connectivity and network bandwidth necessary to consistently download and apply software updates and security patches. However, even unconnected computers contract viruses and malware through the sharing of USB flash drives and other removable media. This paper introduces FlashPatch, a system for distributing software updates to computers in such areas by having software updates "piggy-back" on the existing flow of flash drives in rural regions. FlashPatch requires no changes in user behavior once the software has been installed. We implemented a proof-of-concept FlashPatch prototype and evaluated it in a field trial in Ghana. We present data on the prevalence and spread of viruses at our study site and offer experimental evidence of FlashPatch's effectiveness from a nine-month field trial. We found that FlashPatch provided additional antivirus protection to 30% of the machines in our study without imposing any tangible burdens on the system owners.
Relation between Body Composition Trajectories from Childhood to Adolescence and Nonalcoholic Fatty Liver Disease Risk

NAFLD has become the leading cause of chronic liver disease in children, as a direct consequence of the high prevalence of childhood obesity. This study aimed to characterize body composition trajectories from childhood to adolescence and their association with the risk of developing nonalcoholic fatty liver disease (NAFLD) during adolescence. The participants were part of the ‘Chilean Growth and Obesity Cohort Study’, comprising 784 children who were followed prospectively from age 3 years. Annual assessments of nutritional status and body composition were conducted, with ultrasound screening for NAFLD during adolescence revealing a 9.8% prevalence. Higher waist circumference measures were associated with NAFLD from age 3 years (p = 0.03), all skin folds from age 4 years (p < 0.01), and DXA body fat measurements from age 12 years (p = 0.01). The fat-free mass index was higher in females (p = 0.006) but not in males (p = 0.211). The second and third tertiles of the fat mass index (FMI) had odds ratios for NAFLD during adolescence of 2.19 (1.48–3.25, 95% CI) and 6.94 (4.79–10.04, 95% CI), respectively. Elevated waist circumference, skin folds, and total body fat were identified as risk factors for future NAFLD development. A higher FMI during childhood was associated with an increased risk of NAFLD during adolescence.
Marching through the Visible Man

The National Library of Medicine is creating a digital atlas of the human body. This project, called the Visible Human, has already produced computed tomography, magnetic resonance imaging and physical cross-sections of a human male cadaver. This paper describes a methodology and results for extracting surfaces from the Visible Male's CT data. We use surface connectivity and isosurface extraction techniques to create polygonal models of the skin, bone, muscle and bowels. We also report early experiments with the physical cross-sections.
Implications of circadian clocks for the rhythmic delivery of cancer therapeutics

The circadian timing system (CTS) controls drug metabolism and cellular proliferation over the 24 hour day through molecular clocks in each cell. These cellular clocks are coordinated by a hypothalamic pacemaker, the suprachiasmatic nuclei, that generates or controls circadian physiology. The CTS plays a role in cancer processes and their treatments through the downregulation of malignant growth and the generation of large and predictable 24 hour changes in toxicity and efficacy of anti-cancer drugs. The tight interactions between circadian clocks, cell division cycle and pharmacology pathways have supported sinusoidal circadian-based delivery of cancer treatments. Such chronotherapeutics have been mostly implemented in patients with metastatic colorectal cancer, the second most common cause of death from cancer. Stochastic and deterministic models of the interactions between circadian clock, cell cycle and pharmacology confirmed the poor therapeutic value of both constant-rate and wrongly timed chronomodulated infusions. An automaton model for the cell cycle revealed the critical roles of variability in circadian entrainment and cell cycle phase durations in healthy tissues and tumours for the success of properly timed circadian delivery schedules. The models showed that additional therapeutic strategy further sets the constraints for the identification of the most effective chronomodulated schedules.
Computation and theory of extended Mordell-Tornheim-Witten sums

We consider some fundamental generalized Mordell{Tornheim{Witten (MTW) zeta-function values along with their derivatives, and explore connections with multiple- zeta values (MZVs). To achieve this, we make use of symbolic integration, high precision numerical integration, and some interesting combinatorics and special-function theory. Our original motivation was to represent unresolved constructs such as Eulerian log- gamma integrals. We are able to resolve all such integrals in terms of a MTW basis. We also present, for a substantial subset of MTW values, explicit closed-form expressions. In the process, we signicantly extend methods for high-precision numerical computation of polylogarithms and their derivatives with respect to order.
Efficacy and safety of insulin degludec given as part of basal–bolus treatment with mealtime insulin aspart in type 1 diabetes: a 26-week randomized, open-label, treat-to-target non-inferiority trial

The efficacy and safety of insulin degludec (IDeg) was compared with insulin detemir (IDet), both administered once daily (OD) as basal treatment in participants with type 1 diabetes mellitus (T1DM). The primary outcome was non‐inferiority of IDeg to IDet in glycated haemoglobin (HbA1c) reduction after 26 weeks.
Multisensory Activation of the Intraparietal Area When Classifying Grating Orientation: A Functional Magnetic Resonance Imaging Study

Humans can judge grating orientation by touch. Previous studies indicate that the extrastriate cortex is involved in tactile orientation judgments, suggesting that this area is related to visual imagery. However, it has been unclear which neural mechanisms are crucial for the tactile processing of orientation, because visual imagery is not always required for tactile spatial tasks. We expect that such neural mechanisms involve multisensory areas, because our perception of space is highly integrated across modalities. The current study uses functional magnetic resonance imaging during the classification of grating orientations to evaluate the neural substrates responsible for the multisensory spatial processing of orientation. We hypothesized that a region within the intraparietal sulcus (IPS) would be engaged in orientation processing, regardless of the sensory modality. Sixteen human subjects classified the orientations of passively touched gratings and performed two control tasks with both the right and left hands. Tactile orientation classification activated regions around the right postcentral sulcus and IPS, regardless of the hand used, when contrasted with roughness classification of the same stimuli. Right-lateralized activation was confirmed in these regions by evaluating the hemispheric effects of tactile spatial processing with both hands. In contrast, visual orientation classification activated the left middle occipital gyrus when contrasted with color classification of the same stimuli. Furthermore, visual orientation classification activated a part of the right IPS that was also activated by the tactile orientation task. Thus, we suggest that a part of the right IPS is engaged in the multisensory spatial processing of grating orientation.
Responsiveness in DoC and individual variability

Neuroimaging has shown the capability of the severely injured brain to retain high-level functional aspects across sensory modalities, language processing, and learning dynamics also in the vegetative state/unresponsive wakefulness syndrome (VS/UWS) (Monti et al., 2010a; Monti, 2012; Gibson et al., 2014; Gosseries et al., 2014). Regional brain activations suggesting awareness and cognition were reported in a small number of subjects (Monti et al., 2010a); whether these activations should be considered equivalent to consciousness or compatible with, but atypical for VS/UWS is a matter of debate (Bruno et al., 2010; Monti et al., 2010b; Bardin et al., 2011; Celesia, 2013). The residual functions were otherwise thought to result from intact but functionally disconnected cortical modules that do not necessarily give rise to phenomenal consciousness. The preservation of specific neural structures and available residual cognitive resources has been suggested to vary in these patients because of the heterogeneity of etiology and pathophysiology or extension and severity of brain damage (Gibson et al., 2014).
Geometry and Meaning

From Pythagoras's harmonic sequence to Einstein's theory of relativity, geometric models of position, proximity, ratio, and the underlying properties of physical space have provided us with powerful ideas and accurate scientific tools. Currently, similar geometric models are being applied to another type of space the conceptual space of information and meaning, where the contributions of Pythagoras and Einstein are a part of the landscape itself. The rich geometry of conceptual space can be glimpsed, for instance, in internet documents: while the documents themselves define a structure of visual layouts and point-to-point links, search engines create an additional structure by matching keywords to nearby documents in a spatial arrangement of content. What the "Geometry of Meaning" provides is a much-needed exploration of computational techniques to represent meaning and of the conceptual spaces on which these representations are founded. "
TRAIL and KILLER Are Expressed and Induce Apoptosis in the Murine Preimplantation Embryo1

Abstract TRAIL (tumor necrosis factor [TNF]-related apoptosis-inducing ligand) and KILLER are a death-inducing ligand and receptor pair that belong to the TNF and TNF-receptor superfamilies, respectively. To date, only one apoptosis-inducing TRAIL receptor (murine KILLER [MK]) has been identified in mice, and it is a homologue of human Death Receptor 5. Whereas the expression of other death receptors, such as Fas and TNF receptor 1 have been documented in mammalian preimplantation embryos, no evidence currently demonstrates either the presence or the function of TRAIL and its corresponding death receptor, MK. Using reverse transcription-polymerase chain reaction and confocal immunofluorescent microscopy, we found that both TRAIL and MK are expressed from the 1-cell through the blastocyst stage of murine preimplantation embryo development. These proteins are localized mainly at the cell surface from the 1-cell through the morula stage. At the blastocyst stage, both TRAIL and MK exhibit an apical staining pattern in the trophectoderm cells. Finally, using the TUNEL assay, we demonstrated that MK induces apoptosis in blastocysts sensitized to TRAIL via actinomycin D. Taken together, these data are the first to demonstrate the presence and function of TRAIL and MK, a death-inducing ligand and its receptor, in mammalian preimplantation embryos.
Classifying children with heavy prenatal alcohol exposure using measures of attention

Deficits in attention are a hallmark of the effects of heavy prenatal alcohol exposure but although such deficits have been described in the literature, no attempt to use measures of attention to classify children with such exposure has been described. Thus, the current study attempted to classify children with heavy prenatal alcohol exposure (ALC) and non-exposed controls (CON), using four measures of attentional functioning: the Freedom from Distractibility index from the Wechsler Intelligence Scale for Children–Third Edition (WISC–III), the Attention Problems scale from the Child Behavior Checklist (CBCL), and omission and commission error scores from the Test of Variables of Attention (TOVA). Data from two groups of children were analyzed: children with heavy prenatal alcohol exposure and non-exposed controls. Children in the alcohol-exposed group included both children with or without fetal alcohol syndrome. Groups were matched on age, sex, ethnicity, and social class. Data were analyzed using backward logistic regression. The final model included the Freedom from Distractibility index from the WISC–III and the Attention Problems scale from the CBCL. The TOVA variables were not retained in the final model. Classification accuracy was 91.7% overall. Specifically, 93.3% of the alcohol-exposed children and 90% of the control children were accurately classified. These data indicate that children with heavy prenatal alcohol exposure can be distinguished from non-exposed controls with a high degree of accuracy using 2 commonly used measures of attention. (JINS, 2004, 10, 271–277.)
A non-line-of-sight error mitigation method for location estimation

Because there are always non-line-of-sight effects in signal propagation, researchers have proposed various algorithms to mitigate the measured error caused by non-line-of-sight. Initially inspired by flocking birds, particle swarm optimization is an evolutionary computation tool for optimizing a problem by iteratively attempting to improve a candidate solution with respect to a given measure of quality. In this article, we propose a new location algorithm that uses time-of-arrival measurements to improve the mobile station location accuracy when three base stations are available. The proposed algorithm uses the intersections of three time-of-arrival circles based on the particle swarm optimization technique to give a location estimation of the mobile station in non-line-of-sight environments. An object function is used to establish the nonlinear relationship between the intersections of the three circles and the mobile station location. The particle swarm optimization finds the optimal solution of the object function and efficiently determines the mobile station location. The simulation results show that the proposed algorithm performs better than the related algorithms in wireless positioning systems, even in severe non-line-of-sight propagation conditions.