Miracle-dz/UniFAR-FTUs huggingface dataset:
EFFECT OF GUAR GUM AND XANTHAN GUM COMPRESSION COATING ON RELEASE STUDIES OF METRONIDAZOLE IN HUMAN FECAL MEDIA FOR COLON TARGETED DRUG DELIVERY SYSTEMS

Objective: Compression coating with polysaccharides such as guar gum (GG) and xanthan gum (XG) mixture has been pioneer to be useful for microflora activated colon drug delivery systems. Method: In the present investigation bacteria triggered colon-targeted delivery of metronidazole (MTZ) was developed by compression coating with GG and XG in different coat weights. Rapidly disintegrating core tablets containing 100 mg of MTZ were prepared and compression coated with 150 mg, 250 mg and 350 mg of granules containing a mixture of GG and XG. Results: Drug release was highly retarded with 350 mg of coat weight, After 24 h of dissolution in human fecal media the cumulative percentage of drug release form the 350 mg compression coated tablets was found to be around 21.0±1.65%. As a result, the coat weight was further reduced to 250 mg. It was perceived that reduction in coat weight to 250 mg did not affect the initial drug release rate in simulated upper gastrointestinal tract (GIT) conditions, but at the end of the 24 h of dissolution the amount of drug release was increased to 84.8±1.22% in simulated human fecal media. On the other hand, 150 mg compression coated tablets showed 28.56±1.89% drug release in upper GIT, which indicates uncontrolled drug release within 5 h of the dissolution study. Conclusion: As a consequence, results of the present investigation shows that compression coated MTZ tablets with 250 mg of guar and xanthan gum coat is most likely to promise in exploiting the MTZ release in colon to treat amoebiasis and other local colonic diseases.
A quantitative analysis of the nerve fibres of the acetabular periosteum of dogs

Summary There are many techniques for the treatment of hip dysplasia, and novel research is currently being undertaken in the hope of obtaining more efficient and less traumatic techniques. The denervation of the hip joint capsule is a simple and effective technique that allows recovery of the functional activity of the affected limbs in significantly less time than other techniques. This surgical procedure consists of removing the acetabular periosteum, thus eliminating the nerve fibres with consequent analgesia. The aim of this investigation was to quantify the number of nerve fibres present in different regions of the acetabular periosteum. The knowledge of regional differences is potentially valuable for the refining of the denervation technique of the hip joint capsule. Thirty canine acetabular fragments were used to compare the nerve fibre density of the periosteum. The results showed a significant difference between the mean density of nerve fibres at the cranial and dorsallateral portion (approximately 75 fibres/mm2) and caudal lateral portion (approximately 60 fibres/mm2) of the acetabulum. Those fibres at the periosteum are almost positioned in a sagittal plane, pointing towards the joint capsule, suggesting the same density in the latter region. These results indicate a new approach to the articular denervation technique, thus obtaining even better results for the treatment of hip dysplasia in dogs.
Microcystin accumulation and potential effects on antioxidant capacity of leaves and fruits of Capsicum annuum

ABSTRACT Surface water, often used for irrigation purposes, may sometimes be contaminated with blooming cyanobacteria and thereby may contain their potent and harmful toxins. Cyanotoxins adversely affect many terrestrial plants, and accumulate in plant tissues that are subsequently ingested by humans. Studies were undertaken to (1) examine the bioaccumulation of microcystins (MCs) in leaves and fruits of pepper Capsicum annuum and (2) examine the potential effects of MCs on antioxidant capacity of these organs. Plants were irrigated with water containing MCs for a period of 3 mo. Data showed that MCs did not accumulate in leaves; however, in fruits the presence of the MC-LR (0.118 ng/mg dry weight) and dmMC-LR (0.077 ng/mg dry weight) was detected. The concentrations of MC-LR in fruit approached the acceptable guideline values and tolerable daily intake for this toxin. Lipid peroxidation levels and flavonoids content were significantly enhanced in both organs of treated plants, while total phenolic concentrations were not markedly variable between control and treated plants. Significant decrease in 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging capacity was noted for both organs. The levels of superoxide anion in fruits and hydroxyl radical in leaves were markedly reduced. Data suggest that exposure to MCs significantly reduced antioxidant capacity of experimental plants, indicating that MCs affected antioxidant systems in C. annuum.
Axisymmetric, Three-Integral Models of Galaxies: A Massive Black Hole in NGC 3379

We fit axisymmetric three-integral dynamical models to NGC 3379 using the line-of-sight velocity distribution obtained from Hubble Space Telescope FOS spectra of the galaxy center and ground-based long-slit spectroscopy along four position angles, with the light distribution constrained by WFPC2 and ground-based images. We have fitted models with inclinations from 29° (intrinsic galaxy type E5) to 90° (intrinsic E1) and black hole masses from 0 to 109 M⊙. The best-fit black hole masses range from 6 × 107 to 2 × 108 M⊙, depending on inclination. The preferred inclination is 90° (edge-on); however, the constraints on allowed inclination are not very strong, owing to our assumption of constant M/LV. The velocity ellipsoid of the best model is not consistent with either isotropy or a two-integral distribution function. Along the major axis, the velocity ellipsoid becomes tangential at the innermost bin, radial in the midrange radii, and tangential again at the outermost bins. The rotation rises quickly at small radii owing to the presence of the black hole. For the acceptable models, the radial-to-tangential [(σ + σ)/2] dispersion in the midrange radii ranges over 1.1 < σr/σt < 1.7, with the smaller black holes requiring larger radial anisotropy. Compared with these three-integral models, two-integral isotropic models overestimate the black hole mass since they cannot provide adequate radial motion. However, the models presented in this paper still contain restrictive assumptions—namely, assumptions of constant M/LV and spheroidal symmetry—requiring yet more models to study black hole properties in complete generality.
Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER[S]

Close contacts between organelles, often called membrane contact sites (MCSs), are regions where lipids are exchanged between organelles. Here, we identify a novel mechanism by which cells promote phospholipid exchange at MCSs. Previous studies have shown that phosphatidylserine (PS) synthase activity is highly enriched in portions of the endoplasmic reticulum (ER) in contact with mitochondria. The objective of this study was to determine whether this enrichment promotes PS transport out of the ER. We found that PS transport to mitochondria was more efficient when PS synthase was fused to a protein in the ER at ER-mitochondria contacts than when it was fused to a protein in all portions of the ER. Inefficient PS transport to mitochondria was corrected by increasing tethering between these organelles. PS transport to endosomes was similarly enhanced by PS production in regions of the ER in contact with endosomes. Together, these findings indicate that PS production at MCSs promotes PS transport out of the ER and suggest that phospholipid production at MCSs may be a general mechanism of channeling lipids to specific cellular compartments.
The Influence of Religious Attendance on Smoking Among Black Men

ABSTRACT Background: Cigarette smoking poses a major public health problem that disproportionately affects Blacks and men. Religious attendance has been shown to be positively associated with health promotion and disease prevention among the Black population. In light of this evidence, this study examined if a similar relationship could be found for religious attendance and smoking in Black men. Methods: The National Survey of American Life (NSAL) study sampled 1,271 African American men and 562 Black Caribbean men. Multivariate logistic regression was used to determine the association between religious attendance and cigarette smoking. Results: After adjusting for age, marital status, household income, education, foreign born status, importance of prayer and major stress, men who reported attending religious services almost every day (odds ratio (OR) = 0.21, 95% confidence interval (CI) = 0.07, 0.62) and weekly (OR = 0.47, 95% CI = 0.29, 0.77) had lower odds of being a current smoker compared to men who reported never attending religious services. Conclusions/Importance: Findings suggest a health benefit in attending religious services on cigarette smoking among Black men in a nationally representative sample. In spite of lower church attendance in Black men in general, our results demonstrate that religious service attendance may still serve as a buffer against cigarette use. Given the emergent attention on faith-based health promotion among men, this conclusion is relevant and timely.
Phenotypes of sleeplessness: stressing the need for psychodiagnostics in the assessment of insomnia

Abstract Insomnia is a too general term for various subtypes that might have different etiologies and therefore require different types of treatment. In this explorative study we used cluster analysis to distinguish different phenotypes in 218 patients with insomnia, taking into account several factors including sleep variables and characteristics related to personality and psychiatric comorbidity. Three clusters emerged from the analysis. The ‘moderate insomnia with low psychopathology’-cluster was characterized by relatively normal personality traits, as well as normal levels of anxiety and depressive symptoms in the presence of moderate insomnia severity. The ‘severe insomnia with moderate psychopathology’-cluster showed relatively high scores on the Insomnia Severity Index and scores on the sleep log that were indicative for severe insomnia. Anxiety and depressive symptoms were slightly above the cut-off and they were characterized by below average self-sufficiency and less goal-directed behavior. The ‘early onset insomnia with high psychopathology’-cluster showed a much younger age and earlier insomnia onset than the other two groups. Anxiety and depressive symptoms were well above the cut-off score and the group consisted of a higher percentage of subjects with comorbid psychiatric disorders. This cluster showed a ‘typical psychiatric’ personality profile. Our findings stress the need for psychodiagnostic procedures next to a sleep-related diagnostic approach, especially in the younger insomnia patients. Specific treatment suggestions are given based on the three phenotypes.
Pediatric trauma transfusion and cognitive aids

Purpose of review Trauma is the most common cause of pediatric mortality. Much of the research that led to life-saving interventions in adults, however, has not been replicated in the pediatric population. Children have important physiologic and anatomic differences from adults, which impact hemostasis and transfusion. Hemorrhage is a leading cause of death in trauma, and children have important differences in their coagulation profiles. Transfusion strategies, including the massive transfusion protocol and use of antifibrinolytics, are still controversial. In addition to the blood that is lost from the injury itself, trauma leads to inflammation and to a dysfunction in hemostasis, causing coagulopathy. Recent findings In one study in which children suffered from mainly blast and penetrating injuries in a combat setting (PEDTRAX trial), the early administration of tranexamic acid was associated with decreased mortality. Some authors suggest that this result may not apply to blunt trauma, which is much more common in children in noncombat settings. Using thromboelastography to guide the administration of recombinant Factor VIIa has been done in selected cases and may represent a future avenue of research. Summary This article explores new research from the past year in pediatric trauma, starting with the physiologic differences in pediatric red blood cells and coagulation profiles. We also looked at the dramatic change in thinking over the past decade in the tolerable level of anemia in critically ill pediatric patients, as well as scales for determining the need for massive transfusion and exploring if the concepts of damage control resuscitation apply to children. Other strategies, such as avoiding hypothermia, and the selective administration of antifibriniolytics, are important in pediatric trauma as well. Future research that is pediatric focused is needed for the optimal care of our youngest patients.
Novel Metamaterial Structures with Low Loss at Millimeter Wave Frequency Range

Two novel millimeter-wave (MMW) metamaterials (MTMs) unit cells operate at 28 GHz for a future fifth generation (5G) mobile network applications had been designed, presented and numerically investigated. Two MTM structures are proposed; namely the double E-shaped resonator (DER) and T-U shaped resonator (TUSR). The DER and TUSR are consists of a double E and combined T-U shaped, each printed on front side of the substrate layer respectively. DER achieves a bandwidth of 0.5 GHz and a return loss of -34 dB, whereas TUSR features a bandwidth of 0.3 GHz and a return loss of -18 dB. The conventional split range resonator (SRR) was optimized to operate at similar frequency for comparison purpose. The simulation results revealed that the proposed DER and TUSR unit cells achieves the lowest loss as opposed to literature with -0.09 dB (0.99 in linear scale) and -0.23 dB (0.97 in linear scale) respectively. Moreover, a well-known algorithm was used to extract the constitutive parameters and the double negative nature of the two novel MTM structures is proven.
Tumour necrosis factor antagonists improve disease activity but not arterial stiffness in rheumatoid arthritis.

OBJECTIVES Systemic inflammation may play an important role in the accelerated atherosclerosis and increased cardiovascular mortality of rheumatoid arthritis (RA). Atorvastatin reduced arterial stiffness in RA patients after only 6 weeks, an effect that may be partially mediated by the immunomodulatory effects of this drug. Suppression of inflammation with tumour necrosis factor (TNF) antagonists may therefore also improve vascular function in RA; however, TNF antagonists have also been shown to cause or exacerbate congestive heart failure in patients with RA and heart failure. The aim of the present study was to examine the effect of treatment with TNF antagonists on arterial stiffness in RA patients with active disease. METHODS Fourteen RA patients (age 55.1 +/- 3.8 yr; disease duration 7.9 +/- 1.3 yr) with high disease activity [disease activity score (DAS28) 7.1 +/- 0.3] commencing treatment with TNF antagonists for the first time were studied. Clinical status and arterial stiffness were measured before and after 6 weeks of TNF antagonist therapy (etanercept, adalimumab or infliximab). RESULTS Arterial stiffness did not change during the study period (the mean augmentation index was 29.1 +/- 2.2% at baseline vs 30.1 +/- 1.8% at week 6; P = 0.504). The DAS28 improved significantly from 7.1 +/- 0.3 to 4.3 +/- 0.4 (P < 0.0001). The erythrocyte sedimentation rate and C-reactive protein [median (range)] were reduced from 44 (12-85) to 15 (3-82) mm/h (P = 0.02) and from 34 (3-95) to 10 (2-61) mg/l (P = 0.007), respectively. CONCLUSIONS Despite significant reductions in synovitis and inflammatory markers in these RA patients, arterial stiffness was not improved by 6 weeks of treatment with TNF antagonists. This result is of relevance given recent reports of potential adverse cardiovascular effects of TNF antagonists in some RA patients.
Prevalence of orthodontic treatment need in permanent dentition of Iranian population: A systematic review and meta-analysis of observational studies

Background: Malocclusion is a common oral health problem and can affect the psychosocial well-being in the long term. Therefore, in the recent decades, demand for orthodontic treatment to correct malocclusion has greatly increased worldwide. This systematic review and meta-analysis was undertaken to assess existing evidence on the prevalence of orthodontic treatment need in Iran. Materials and Methods: National and international databases were searched for articles on the prevalence of orthodontic treatment need using index of orthodontic treatment need (IOTN) and dental aesthetic index (DAI). The required data were completed by hand-searching. After applying the inclusion and exclusion criteria, the quality of articles was checked by a professional checklist. Data extraction and meta-analysis were performed. A random effects model was employed, and publication bias was checked. Results: From a total of 443 articles that reported orthodontic treatment need in Iran, 24 articles were included in the meta-analysis process. Meta-analysis was performed on components of IOTN and DAI. The pooled prevalence of orthodontic treatment need based on Dental Health Component and Aesthetic Component of IOTN and DAI was 23.8% (19.5%–28.7%), 4.8% (3.3%–7%), and 16.1% (12.3%-20.8%). The results were found to be heterogeneous (P < 0.05). Conclusion: The results of this study revealed that orthodontic treatment need was not high in the Iranian population. Considering the differing prevalence of orthodontic treatment need based on normative index and self-perceived index, it is essential to improve the people's awareness of malocclusion and its side effects on their oral and general health.
On lexicographic max-min node lifetime for wireless sensor networks

We study the network lifetime problem by considering not only the maximized time until the first node fails, but also the maximized lifetime for all the nodes in the network which we define as the lexicographic max-min (LMM) node lifetime problem. The main contributions of this paper are two-fold. First, we develop a polynomial-time algorithm to derive the LMM-optimal node lifetime vector, which effectively circumvents the computational complexity problem associated with an existing state-of-the-art approach, which is exponential. Second, we present a simple (also polynomial-time) algorithm to calculate the flow routing schedule such that the LMM-optimal node lifetime vector can be achieved. Our results in this paper advance the state-of-the-art algorithmic design to network-wide node lifetime problems.
Mother–child dietary behaviours and their observed associations with socio-demographic factors: findings from the Healthy Beginnings Trial

Abstract Few studies have investigated the effect of maternal factors on child eating practices. Our study aimed to explore mother–child dietary behaviours and their associations with socio-demographic factors. A cross-sectional analysis was conducted using data from control participants (n 243) in the Healthy Beginnings Trial, which involved first-time mothers and their 2-year-old children. Mother–child dietary behaviours were assessed using short dietary questions (short FFQ) and their associations with socio-demographic factors were examined using binary logistic regression. The dietary intake of 2-year-old children was characterised by low vegetable consumption and high discretionary food intake. In multivariate analysis, lower-income mothers (<Australian $40 000 per annum) reported their child was more likely to consume less fruit (<1 serve/d) (adjusted OR (AOR): 5·83; 95 % CI 1·49, 22·80) and ate hot chips more frequently (≥2 times/week) (AOR: 4·80; 95 % CI 1·28, 18·04), compared with higher-income mothers (≥Australian $40 000 per annum). Younger mothers (<25 years) reported their child consumed more sugary drinks and soft drink (>0·5 cups/d) AOR 2·93 (95 % CI 1·03, 8·35), compared with older mothers (≥25 years). Non-Australian-born mothers reported their child consumed more fruit juice (>0·5 cups/d) AOR 2·04 (95 % CI 1·02, 4·05), sweet snacks AOR 1·96 (95 % CI 1·02, 3·76) and fast food (≥2 times/week) AOR 3·67 (95 % CI 1·29, 10·43) compared with Australian-born mothers. Significant positive correlations between maternal and child dietary intake were observed for all dietary variables except milk, with the largest association for fast foods (Pearson’s r 0·52, P<0·001). This study shows that maternal factors are associated with child dietary behaviours. Targeting young mothers (<25 years) of potential disadvantage, before commencement of early feeding practices, has the potential to improve children’s diets.
Differences in internalization and growth of Escherichia coli O157:H7 within the apoplast of edible plants, spinach and lettuce, compared with the model species Nicotiana benthamiana

Internalization of food‐borne bacteria into edible parts of fresh produce plants represents a serious health risk. Therefore, internalization of verocytotoxigenic E. coli O157:H7 isolate Sakai was assessed in two species associated with outbreaks, spinach (Spinacia oleracea) and lettuce (Lactuca sativa) and compared to the model species Nicotiana benthamiana. Internalization occurred in the leaves and roots of spinach and lettuce throughout a 10 day time‐course. The plant species, tissue type and inoculum dose all impacted the outcome. A combination of low inoculum dose (~102 CFU) together with light microscopy imaging highlighted marked differences in the fate of endophytic E. coli O157:H7 Sakai. In the fresh produce species, bacterial growth was restricted but viable cells persisted over 20 days, whereas there was > 400‐fold (~2.5 Log10) increase in growth in N. benthamiana. Colony formation occurred adjacent to epidermal cells and mesophyll cells or close to vascular bundles of N. benthamiana and contained components of a biofilm matrix, including curli expression and elicitation, extracellular DNA and a limited presence of cellulose. Together the data show that internalization is a relevant issue in crop production and that crop species and tissue need to be considered as food safety risk parameters.