Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and feasibility of integrating personalized PRO dashboards into prostate cancer care

OBJECTIVE Patient-reported outcomes (PROs) are a valued source of health information, but prior work focuses largely on data capture without guidance on visual displays that promote effective PRO use in patient-centered care. We engaged patients, providers, and design experts in human-centered design of "PRO dashboards" that illustrate trends in health-related quality of life (HRQOL) reported by patients following prostate cancer treatment. MATERIALS AND METHODS We designed and assessed the feasibility of integrating dashboards into care in 3 steps: (1) capture PRO needs of patients and providers through focus groups and interviews; (2) iteratively build and refine a prototype dashboard; and (3) pilot test dashboards with patients and their provider during follow-up care. RESULTS Focus groups (n = 60 patients) prioritized needs for dashboards that compared longitudinal trends in patients' HRQOL with "men like me. " Of the candidate dashboard designs, 50 patients and 50 providers rated pictographs less helpful than bar charts, line graphs, or tables (P < .001) and preferred bar charts and line graphs most. Given these needs and the design recommendations from our Patient Advisory Board (n = 7) and design experts (n = 7), we built and refined a prototype that charts patients' HRQOL compared with age- and treatment-matched patients in personalized dashboards. Pilot testing dashboard use (n = 12 patients) improved compliance with quality indicators for prostate cancer care (P < .01). CONCLUSION PRO dashboards are a promising approach for integrating patient-generated data into prostate cancer care. Informed by human-centered design principles, this work establishes guidance on dashboard content, tailoring, and clinical use that patients and providers find meaningful.
Seasonal Variation in Onset of Myocardial Infarction—A 7‐year single‐center study in Italy

Like many other serious acute cardiovascular and cerebrovascular events, acute myocardial infarction (AMI) shows seasonal variation, being most frequent in the winter. We sought to investigate whether age, gender, and hypertension influence this pattern. We studied 4014 (2259 male and 1755 female) consecutive patients with AMI presenting to St. Anna Hospital of Ferrara, Italy between January 1998 and December 2004. Some 1131 (28.2%) of the AMI occurred in persons <65 yrs of age, and 2883 (71.8%) in those ≥65 yrs of age. AMI was over‐represented in males (82% in the <65 yr group vs. 56.6% in the ≥65 yr group (χ2=13.99; p<0.001). Hypertension had been previously documented in 964 (24%) of the cases. There were 691 (17.2%) fatal case outcomes; fatal outcomes were significantly higher among the 3054 normotensive (n=614 or 20.1%) than the 964 hypertensive cases (n=77 or 8%; χ2=74.94, p<0.001). AMIs were most frequent in the winter (n=1076 or 26.8% of all the events) and least in the summer (n=924 or 23.0% of all the events; χ2=12.36, p=0.007). The greatest number of AMIs occurred in December (n=379 or 9.44%), and the lowest number in September (n=293 or 7.3%; χ2=11.1, p=0.001). Inferential chronobiological (Cosinor) analysis identified a significant annual pattern in AMI in those ≥65 yrs of age, with a peak between December and February—January for the total sample (p<0.005), January for the sample of males (p=0.014), February for fatal infarctions (p=0.017), and December for non‐fatal infarctions (p=0.006). No such temporal variations were detected in any of these categories in those <65 yrs of age. The annual pattern in AMI was also verified by Cosinor analysis in the following hypertensive subgroups: hypertensive males (n=552: January, p=0.014), non‐fatal infarctions in hypertensive patients (n=887: January, p=0.018), and elderly normotensives (n=1556: November, p=0.007).
The association of cyclin D1 G870A and E‐cadherin C‐160A polymorphisms with the risk of colorectal cancer in a case control study and meta‐analysis

Cyclin D1 (CCND1) and E‐cadherin (CDH1) have been shown to be important genes of the β‐catenin/LEF pathway that is involved in colorectal carcinogenesis. However, epidemiological studies on relationship between genetic variants of these two genes and colorectal cancer (CRC) have shown inconsistent results. In a population‐based case‐control study (498 cases and 600 controls), we assessed the association of CCND1 G870A and CDH1 C‐160A polymorphisms with CRC risk. Multivariable logistic regression analysis was used to estimate the association between genotypes, environmental exposures and CRC risk, adjusting for potential confounders. Compared to common homozygotes, the OR for heterozygous and homozygote variant genotype was 1.08 (95% CI, 0.80–1.46) in CCND1 and 0.97 (95% CI, 0.75–1.25) in CDH1. Neither tumor stage nor location showed an association with genetic susceptibility. However, a significant interaction between hormone replacement therapy (HRT) and CCND1 genotypes in CRC risk was found among postmenopausal women (pinteraction = 0.02). The risk reduction associated with HRT was substantial (OR, 0.09; 95% CI, 0.02–0.35) in women who were GG homozygous. A meta‐analyses including 11 published studies on CCND1 G870A in addition to our study showed a slightly increased risk of CRC for carriers of the A allele (OR, 1.19; 95% CI, 1.06–1.34); however, there was some indication of publication bias. We conclude that the CCND1 G870A and CDH1 C‐160A polymorphisms are not associated with the risk of CRC in the German population. However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC. © 2008 Wiley‐Liss, Inc.
Comparison of Computational Aeroacoustic Prediction Methods for Transonic Rotor Noise

This paper compares two methods for predicting transonic rotor noise for helicopters in hover and forward e ight. Both methods rely on a computational e uid dynamics (CFD) solution as input to predict the acoustic near and far e elds. For this work, the same full-potential rotor code has been used to compute the CFD solution for both acoustic methods. The e rst method employs the acoustic analogy as embodied in the Ffowcs Williams› Hawkings equation, including the quadrupole term. The second method uses a rotating Kirchhoff formulation. Computed results from both methods are compared with one another and with experimental data for both hover and advancing rotor cases. The results are quite good for all cases tested. The Kirchhoff method was somewhat sensitive to the location of Kirchhoff surface, if the surface was positioned too close to the rotor blade. The acoustic analogy method was not as sensitive to the extent of volume included in the quadrupole calculation. The computational requirements of both methods are comparable; in both cases these requirements are much less than the requirements for the CFD solution.
The Nutritional Knowledge, Eating Habits, and Body Image of Adolescent Females

This mixed methods investigation examined the nutritional knowledge and habits of adolescent girls in grades 9 through 12 at a secondary school in southern Ontario. Through questionnaires, interviews, and the use of teaching and curriculum documents, this study attempted to understand whether the current nutrition curriculum is influential in developing students' nutritional knowledge, healthy eating habits, and a favourable body image. Data collection occurred over a 2-month period, involving 90 female participants, and the data analysis program SPSS was used for analysis of the quantitative questionnaire data. Interview data were organized into categories, and analysis of any emerging themes occurred. Teaching and curriculum documents were examined to determine any overlap and develop an understanding of the participants' exposure and experience within nutrition within the classroom setting. The findings of this study suggest that the current nutrition education did have an impact on the participants' nutrition knowledge. However, the impact on their eating habits and body image was limited in the context it was measured and tested. The knowledge learned within the classroom may not always be applied outside of the classroom. This study suggests that improvement in the current nutrition curriculum may be needed to have a bigger impact on adolescent females. The findings from the study shine light on areas of improvements for educators as well as development of future curriculum. Changes may need to be made not only in the specific curriculum content and expectations but also the delivery of it by the classroom teacher.
Le Bon Usage

En 1936 paraîssait la première édition du bon usage , conçu dans l'esprit de Vaugelas par un jeune professeur de français, Mauri ce Grevisse (1895-1980). Déjà largement plébiscité dès les premières édition s, le bon usage allait connaître une diffusion fulgurante à la suite d'un retentissant article d'André Gide. En 1947, le célèbre écrivain le recommandait aux lecteurs du supplément littéraire du journal Le Figaro comme la meilleure grammaire française. Le Bon Usage est une grammaire, mais bien plus qu'une grammaire, il est le reflet de l'évolution de la langue française à travers le temps et l'espa c . Le premier devoir du grammairien est d'observer et de décrire, car la langue est l reflet de l'usage. Le Bon Usage en est l'expression même.
Mixed-phenotype acute leukemia: current challenges in diagnosis and therapy

Purpose of review Mixed-phenotype acute leukemia (MPAL) is a rare disease that poses many diagnostic and therapeutic challenges. Patients with MPAL are considered to have poor outcomes. The difficulties in classifying this leukemia, the lack of prospectively collected data concerning therapeutic outcomes, and rare incidence result in much uncertainty as to the best approach for patients with MPAL. Recent findings Recent studies demonstrated that most MPALs are associated with cytogenetic abnormalities; genetic sequencing studies disclose a high frequency of somatic mutations in genes encoding epigenetic regulators, tumor suppressors, and transcription factors. The limited available data suggest that higher remission rates are achieved with acute lymphoblastic leukemia-like induction regimens compared with acute myeloid leukemia-type approaches. Allogeneic transplantation in first remission may be associated with improved survival compared with consolidation chemotherapy. Summary Advances in understanding the genetic landscape of MPAL may allow a more biologically driven classification of this heterogeneous group of leukemias in the future that will lead to optimized therapies for individual patients. Most data that inform therapy are based on retrospective, uncontrolled studies; prospective trials that incorporate targeted approaches based on genetics and immunophenotype are needed.
The Dimensions of Religiosity: A Conceptual Model with an Empirical Test

This paper develops and tests a conceptual model of religiosity. Particular attention is given to measuring the dimensions of religiosity among Mormons, but the model is adaptable to the study of religiosity within other denominations and groups. Six dimensions are theoretically derived by a cross-classification of three general components: religious belief, commitment, and behavior; and two modes of religiosity: personal and institutional. An empirical test of the model is reported using data collected from a large sample of Mormons.
Rapid Conversion of Pseudomonas aeruginosa to a Spherical Cell Morphotype Facilitates Tolerance to Carbapenems and Penicillins but Increases Susceptibility to Antimicrobial Peptides

ABSTRACT The Gram-negative human pathogen Pseudomonas aeruginosa tolerates high concentrations of β-lactam antibiotics. Despite inhibiting the growth of the organism, these cell wall-targeting drugs exhibit remarkably little bactericidal activity. However, the mechanisms underlying β-lactam tolerance are currently unclear. Here, we show that P. aeruginosa undergoes a rapid en masse transition from normal rod-shaped cells to viable cell wall-defective spherical cells when treated with β-lactams from the widely used carbapenem and penicillin classes. When the antibiotic is removed, the entire population of spherical cells quickly converts back to the normal bacillary form. Our results demonstrate that these rapid population-wide cell morphotype transitions function as a strategy to survive antibiotic exposure. Taking advantage of these findings, we have developed a novel approach to efficiently kill P. aeruginosa by using carbapenem treatment to induce en masse transition to the spherical cell morphotype and then exploiting the relative fragility and sensitivity of these cells to killing by antimicrobial peptides (AMPs) that are relatively inactive against P. aeruginosa bacillary cells. This approach could broaden the repertoire of antimicrobial compounds used to treat P. aeruginosa and serve as a basis for developing new therapeutic agents to combat bacterial infections.
Polymorphisms in the vitamin D receptor gene, ultraviolet radiation, and susceptibility to prostate cancer

Ultraviolet radiation (UVR) exposure may protect against prostate cancer development via a mechanism involving vitamin D. The vitamin D receptor (VDR) gene is therefore a candidate susceptibility factor for prostate cancer. This possibility has been previously investigated with conflicting results. We examined the association of VDR genotypes (variants at the CDX‐2, Fok1, and Taq1 sites), haplotypes, and genotype combinations with risk by studying 368 prostate cancer and 243 benign prostatic hypertrophy (BPH) patients. CDX‐2, Fok1, and Taq1 genotype and haplotype frequencies were not significantly different in cancer and BPH patients. As the impact of VDR polymorphisms may depend on UVR exposure, we studied associations of variants with risk in men stratified into low (below median) and high (above median) cumulative exposure/year groups. In men with UVR exposure above the median (1,100 hr/year), CDX‐2 GA and AA (odds ratios [OR] = 2.11 and 2.02, respectively) and Fok1 ff (OR = 2.91) were associated with increased prostate cancer risk. No associations were observed for Taq1 genotypes. Of the genotype combinations, relative to all other CDX‐2 and Taq1 and combinations, GGTT (P = 0.022, OR = 0.30), and relative to all other Fok1 and Taq1 combinations, FFTT (P = 0.026, OR = 0.35) were associated with reduced prostate cancer risk in the presence of the main effects. None of the other two‐ or three‐genotype combinations was associated with risk. These data indicate that VDR variants influence prostate cancer risk and that this association is dependent on the extent of UVR exposure. Environ. Mol. Mutagen. 43:121–127, 2004. © 2004 Wiley‐Liss, Inc.
Women's Labor History, 1790-1945

Before 1968, books that dealt with the history of women and work in the U.S. barely occupied one library shelf. ' Stimulated by the reemergence of feminism, the activism of the New Left, and the advent of the "new" social history in the 1960s and 1970s, not only have scholars created a new literature in women's labor history, but their work has burgeoned in size and matured in conceptualization during the past twenty years. The concern of feminists and the New Left for issues of class, gender, and work inspired the growth of the field; its continued vitality reflects the central importance of its paradigms to women's history. By contrast with traditional labor historians, feminist historians refused to accept descriptions of women's secondary role in the labor force without inquiring how that subordinate position came to be and continued to be reinforced. They sought evidence as well that women were active agents in the creation of history and they valorized their activities in strikes and protest movements. Analytically they joined reproduction with production; understanding the intersection of home and workplace became a hallmark of women's labor history.2 Yet the field's gaps reflect the influence of white and male models in labor history. Scholars of women's labor have accorded the most attention to industrial work although in no historical period was it the major employer of women; far less studied are agriculture and service occupations, not only the source of work for most women in the nineteenth century, but also the primary employers of black and Mexican women until the postwar era. More diversified in their analyses of organizations, women's labor historians have not only examined women's union militance, but analyzed uniquely female forms of protest in women's auxiliaries and cross-class alliances. Relatively few monographs treat women of color, and only a tiny handful compare racial, gender, and class hierarchies as they were played out among differing groups of women. The proliferation and complexity as well as the limitations of the field demand codification and a compass to chart the direction of further research. The following essay will review the terrain U.S. women's labor history has mapped and will suggest fields for future exploration.
Life promises and ‘failed’ family ties: expectations and disappointment within a clinical trial (Ivory Coast)

Building on fieldwork carried out in a clinical trial looking at early antiretroviral treatment for HIV in Abidjan, this paper aims to analyse the way relations emerge during trials and the consequences of the end of participation. Instead of discussing it using the register of ethics, understood as a universal set of principles, the trial is analysed for what it means locally for its actors, mainly patients. From this standpoint, the trial can be defined as both a promise of life and of new possibilities embodied in what is often described as new family ties. How are such ties formed and what does it mean when these ties are broken at the end of patient participation? Discussing the failure of family ties commented upon by patients and dealt by physician researcher is a way to look at ethics from below.
The role of banks in the mobile payment ecosystem: a strategic asset perspective

Markets in developed countries have witnessed the launch of a number of mobile payment initiatives over the last years. Even though the emergence of mobile payments may still hold high promises, most of these initiatives have seen stagnation or failure. Traditionally, dominant firms from various industries had to negotiate the exchange of their complementary resources and capabilities in order to provide a mobile payment platform. Indeed, significant efforts have been made to design a satisfying business model to enhance this essential collaboration. However, the struggle for these inter-dependent firms to form coalitions just hindered the emergence of successful mobile payment platforms. As firms have difficulties to self-orchestrate their efforts to shape sustainable ecosystems, different industry architectures solving the inter-dependency issue remain to be investigated. In certain architectures, the importance of the banks' role has been questioned. This paper takes a resource-based view on banks to explore how resources/capabilities bestow upon banks a competitive advantage in the mobile payment ecosystem. The analysis leads to the identification of strategic assets, owing to which it can be argued that the banks still have an essential role to play in the industry architecture.
An automated system for whole microscopic image acquisition and analysis

The field of anatomic pathology has experienced major changes over the last decade. Virtual microscopy (VM) systems have allowed experts in pathology and other biomedical areas to work in a safer and more collaborative way. VMs are automated systems capable of digitizing microscopic samples that were traditionally examined one by one. The possibility of having digital copies reduces the risk of damaging original samples, and also makes it easier to distribute copies among other pathologists. This article describes the development of an automated high‐resolution whole slide imaging (WSI) system tailored to the needs and problems encountered in digital imaging for pathology, from hardware control to the full digitization of samples. The system has been built with an additional digital monochromatic camera together with the color camera by default and LED transmitted illumination (RGB). Monochrome cameras are the preferred method of acquisition for fluorescence microscopy. The system is able to digitize correctly and form large high resolution microscope images for both brightfield and fluorescence. The quality of the digital images has been quantified using three metrics based on sharpness, contrast and focus. It has been proved on 150 tissue samples of brain autopsies, prostate biopsies and lung cytologies, at five magnifications: 2.5×, 10×, 20×, 40×, and 63×. The article is focused on the hardware set‐up and the acquisition software, although results of the implemented image processing techniques included in the software and applied to the different tissue samples are also presented. Microsc. Res. Tech. 77:697–713, 2014. © 2014 Wiley Periodicals, Inc.
Phenotype of the herpes simplex virus type 1 protease substrate ICP35 mutant virus

The herpes simplex virus type 1 ICP35 assembly protein is involved in the formation of viral capsids. ICP35 is encoded by the UL26.5 gene and is specifically processed by the herpes simplex virus type 1 protease encoded by the UL26 gene. To better understand the functions of ICP35 in infected cells, we have isolated and characterized an ICP35 mutant virus, delta ICP35. The mutant virus was propagated in complementing 35J cells, which express wild-type ICP35. Phenotypic analysis of delta ICP35 shows that (i) mutant virus growth in Vero cells was severely restricted, although small amounts of progeny virus was produced; (ii) full-length ICP35 protein was not produced, although autoproteolysis of the protease still occurred in mutant-infected nonpermissive cells; (iii) viral DNA replication of the mutant proceeded at wild-type levels, but only a very small portion of the replicated DNA was processed to unit length and encapsidated; (iv) capsid structures were observed in delta ICP35-infected Vero cells by electron microscopy and by sucrose sedimentation analysis; (v) assembly of VP5 into hexons of the capsids was conformationally altered; and (vi) ICP35 has a novel function which is involved in the nuclear transport of VP5.