Miracle-dz/UniFAR-FTUs huggingface dataset:
BRITTLE CULM1, Which Encodes a COBRA-Like Protein, Affects the Mechanical Properties of Rice Plants Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.011775.

Plant mechanical strength is an important agronomic trait. To understand the molecular mechanism that controls the plant mechanical strength of crops, we characterized the classic rice mutant brittle culm1 (bc1) and isolated BC1 using a map-based cloning approach. BC1, which encodes a COBRA-like protein, is expressed mainly in developing sclerenchyma cells and in vascular bundles of rice. In these types of cells, mutations in BC1 cause not only a reduction in cell wall thickness and cellulose content but also an increase in lignin level, suggesting that BC1, a gene that controls the mechanical strength of monocots, plays an important role in the biosynthesis of the cell walls of mechanical tissues.
Human umbilical cord and dental pulp-derived mesenchymal stem cells: Biological characteristics and potential roles in vitro and in vivo

Mesenchymal stem/stromal cells (MSCs) have a wide application in cell-based therapies and tissue engineering. In the present study, the differentiation, survivin (SVV)-modified effects and molecular basis of human umbilical cord-derived MSCs (HUMSCs) and dental pulp-derived stem cells (DPSCs) were investigated. The HUMSCs were found to differentiate into adipocytes more readily than the DPSCs and the HUMSCs and DPSCs were each able to differentiate into osteoblasts and chondroblasts. Following modification of the MSCs by SVV, the secretion of SVV in the modified HUMSCs was significantly higher compared with that in the modified DPSCs. In vivo, survival of the SVV-modified DPSCs was observed at 4 and 14 days after intrastriatal transplantation, as was the expression of SVV and differentiation into astrocytes. The gene expression profiles of the control and modified HUMSCs and DPSCs were compared using RNA sequencing and an association was observed between gene expression and variability in cell line function. These findings provide novel information regarding the differences between HUMSCs and DPSCs and insight into optimal cell sources for therapeutic applications.
Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells

Retinoic acid (RA) induces cell cycle arrest and differentiation of human neuroblastoma (NB) cells. Typically, NB cells differentiate along the neuronal lineage, but quiescent, “flat” cell types frequently have been described after treatment with differentiating agents. Two indistinguishable subclones of the cell line SK-N-SH, SK-N-SH-N (SH-N) and SK-N-SH-F (SH-F), display dramatically different responses to RA. In SH-N, RA induces neuronal differentiation, but in SH-F it transforms the small neuroblastic cells into large, flattened, epithelium-like cells. Here we analyze the mechanistic basis for the different effects of RA in the two NB subclones. First, we show that the flattened RA-treated SH-F expresses markers of cells undergoing replicative senescence. Inhibition of DNA synthesis by RA is significantly more rapid in SH-F than in SH-N. SH-F, which expresses basal amounts of p16INK4A, responds to RA with elevation of p18INK4C, marked down-regulation of cyclin D1, and swift inhibition of cyclin D-dependent kinases (cdks). Conversely, after addition of RA, SH-N retains cell cycling due to high expression of cyclin D1, the absence of Ink4 inhibitors, and accumulation of p21Cip1. These changes result in sustained cdk activity. Accordingly, overexpression of p21Cip1 but not p16INK4A induces neuronal differentiation of untreated NB cells. We propose that rapid inhibition of cdks by RA in NB leads to early cell cycle arrest, prevents neuronal differentiation, and results in a senescence-like state.
Differential Effects of Dopaminergic Therapies on Dorsal and Ventral Striatum in Parkinson's Disease: Implications for Cognitive Function

Cognitive abnormalities are a feature of Parkinson's disease (PD). Unlike motor symptoms that are clearly improved by dopaminergic therapy, the effect of dopamine replacement on cognition seems paradoxical. Some cognitive functions are improved whereas others are unaltered or even hindered. Our aim was to understand the effect of dopamine replacement therapy on various aspects of cognition. Whereas dorsal striatum receives dopamine input from the substantia nigra (SN), ventral striatum is innervated by dopamine-producing cells in the ventral tegmental area (VTA). In PD, degeneration of SN is substantially greater than cell loss in VTA and hence dopamine-deficiency is significantly greater in dorsal compared to ventral striatum. We suggest that dopamine supplementation improves functions mediated by dorsal striatum and impairs, or heightens to a pathological degree, operations ascribed to ventral striatum. We consider the extant literature in light of this principle. We also survey the effect of dopamine replacement on functional neuroimaging in PD relating the findings to this framework. This paper highlights the fact that currently, titration of therapy in PD is geared to optimizing dorsal striatum-mediated motor symptoms, at the expense of ventral striatum operations. Increased awareness of contrasting effects of dopamine replacement on dorsal versus ventral striatum functions will lead clinicians to survey a broader range of symptoms in determining optimal therapy, taking into account both those aspects of cognition that will be helped versus those that will be hindered by dopaminergic treatment.
Modeling of cadmium bioaccumulation in two populations of the green mussel Perna viridis

This study attempted to quantify differences in Cd biokinetics from two populations of green mussels (Perna viridis) from two sites (eastern and western) in Hong Kong with contrasting hydrological conditions. Body Cd concentrations were modeled using a simple biokinetic model coupled with measurements of dissolved Cd concentrations at each site. Mussels collected from the western site had three to six times higher Cd tissue concentration than the eastern population collected during two seasons (summer wet and winter dry), but the salinity was only lower in the western site during the summer. More Cd was distributed in the metallothionein‐like and heat‐sensitive proteins in the western population than the eastern population, and Cd predominantly was distributed in the insoluble fraction during summer. The Cd uptake rate constant from the dissolved phase was higher in the western population during summer due to a much lower salinity, but was comparable during winter. Dietary uptake of Cd was similar in both populations, and assimilation was lower from ingested radiolabeled seston than from diatoms. Efflux of Cd remained comparable between the two populations from two seasons (0.02–0.03/d). Kinetic modeling demonstrates that the faster influx of Cd from aqueous phase caused the higher body Cd concentrations in the western population. The predicted Cd concentrations in mussels were comparable to those observed in the field. Our study highlights differences in Cd accumulation kinetics in different populations of mussels likely caused by the different physical environments.
Collision-free MAC scheduling algorithms for wireless ad hoc networks

Providing quality of service (QoS) in wireless ad hoc networks introduces a major challenge due to their dynamic topologies. In general, a QoS scheme requires close collaboration between all layers in the protocol stack. At the base of the scheme is a QoS capable MAC protocol. In ad hoc networks nowadays, the widely deployed distributed coordination function (DCF) proposed by the IEEE 802.11 standard is a random access scheme and suffers from a fairness problem. In order to provide a guarantee of minimal throughput and improve the fairness of bandwidth sharing, a class of collision-free MAC scheduling algorithms is proposed. When implementing these algorithms, the set of node identifiers (IDs) that can connect to the network should be known in advance. In addition, neighborhood information sharing is required. Compared with their counterparts proposed in the literature, these algorithms can guarantee a minimal throughput and do not rely on per-packet information exchange. Simulation results show that these algorithms can provide better long term fairness when compared with IEEE 802.11 DCF, even when they are implemented in coarse time granularity.
Exploiting the Cost (In)sensitivity of Decision Tree Splitting Criteria

This paper investigates how the splitting criteria and pruning methods of decision tree learning algorithms are influenced by misclassification costs or changes to the class distribution. Splitting criteria that are relatively insensitive to costs (class distributions) are found to perform as well as or better than, in terms of expected misclassification cost, splitting criteria that are cost sensitive. Consequently there are two opposite ways of dealing with imbalance. One is to combine a costinsensitive splitting criterion with a cost insensitive pruning method to produce a decision tree algorithm little affected by cost or prior class distribution. The other is to grow a cost-independent tree which is then pruned in a cost-sensitive manner.
Zernike Velocity Moments for Description and Recognition of Moving Shapes

New Zernike velocity moments have been developed to describe an object, not only by its shape , but also by its motion throughout an image sequence. These are an extended form of the orthogonal Zernike moment set and include velocity information introduced via centralised moments. Initial analysis shows that they perform well when applied to analysing gait sequences resulting in a good recognition rate and a compact description. They have exhibited promising attributes when applied to occluded data, which is reflected in the method of describing a complete temporal sequence and not single images. Further, they appear to provide measures intimately related to the moving and/or morphing shape within the sequence. Their invariance properties suggest that they will be useful in real situations where poor quality or camera zoom problems are apparent.
A DBN-BASED MULTI-LEVEL STOCHASTIC SPOKEN LANGUAGE UNDERSTANDING SYSTEM

In a previous paper, extensions of the 2-level stochastic speech understanding system have been proposed. Firstly the 3-level system is obtained through the introduction of a stochastic concept value normalization module. Then the 2+1-level system is obtained as a degraded 3-level system where the conceptual decoding and value normalization steps are decoupled, thus allowing to greatly reduce the model complexity and improve its trainability. In this paper, a multi-level spoken language understanding system is presented. This stochastic module is for the first time based on dynamic Bayesian networks. Factored language models with a generalized parallel backoff procedure are used as edge implementation to provide efficiently smoothed conditional probability estimates. This framework allows a great flexibility in terms of probability representation facilitating the development of the stochastic levels of the system. The proposed approaches, 3-level and 2+1-level, are evaluated on the French MEDIA task (tourist information and hotel booking). The MEDIA 10k-utterance training corpus is segmentally annotated, allowing a direct training of the various levels of the conceptual models. The best DBN-based system obtains performance comparable to those of the MEDIA'05 evaluation campaign best system (H. Bonneau-Maynard et al., 2005).
Acoustic surveying of pelagic fish in shallow water

The acoustic monitoring program at the Prince William Sound Science Center is used to illustrate the application of acoustic techniques to surveying pelagic fish biomass. The herring population in Prince William Sound, Alaska, collapsed after the Exxon Valdez Oil Spill in 1989. Fishery-dependent information was not adequate either to halt the collapse or to understand its ramifications. Fishery-independent observational techniques like acoustics not only provide more timely information for management, but also provide additional information on other components of the ecosystem. After the herring collapse, information from acoustic surveys in Prince William Sound was used to show that both the oil spill and overfishing contributed to the collapse, and the loss of critical forage resulted in parallel declines of many seabirds and marine mammals, including the endangered Steller sea lion.
Atherosclerotic cardiovascular disease in patients with chronic inflammatory joint disorders

Inflammatory joint disorders (IJD), including rheumatoid arthritis (RA), ankylosing spondylitis (ASp) and psoriatic arthritis (PsA), are prevalent conditions worldwide with a considerable burden on healthcare systems. IJD are associated with increased cardiovascular (CV) disease-related morbidity and mortality. In this review, we present an overview of the literature. Standardised mortality ratios are increased in IJD compared with the general population, that is, RA 1.3–2.3, ASp 1.6–1.9 and PsA 0.8–1.6. This premature mortality is mainly caused by atherosclerotic events. In RA, this CV risk is comparable to that in type 2 diabetes. Traditional CV risk factors are more often present and partially a consequence of changes in physical function related to the underlying IJD. Also, chronic systemic inflammation itself is an independent CV risk factor. Optimal control of disease activity with conventional synthetic, targeted synthetic and biological disease-modifying antirheumatic drugs decreases this excess risk. High-grade inflammation as well as anti-inflammatory treatment alter traditional CV risk factors, such as lipids. In view of the above-mentioned CV burden in patients with IJD, CV risk management is necessary. Presently, this CV risk management is still lacking in usual care. Patients, general practitioners, cardiologists, internists and rheumatologists need to be aware of the substantially increased CV risk in IJD and should make a combined effort to timely initiate CV risk management in accordance with prevailing guidelines together with optimal control of rheumatic disease activity. CV screening and treatment strategies need to be implemented in usual care.
Progress in the management and outcome of small-cell lung cancer in a French region from 1981 to 1994

Recent analyses of series of small-cell lung cancer (SCLC) patients included in clinical trials have shown improved survival over time, but it has been impossible to determine whether this was due to selection biases, stage migration, or true therapeutic improvement. To determine if there has been a true improvement of survival over time, we reviewed the medical records of all consecutive patients diagnosed with SCLC between 1981 and 1994 in the Bas-Rhin in France. Among the 787 patients (median age 63), there was no significant period effect for sex, age, or stage. Staging work-ups became increasingly thorough (significant period effect). The mean number of investigations and of tumour sites detected correlated significantly. The chemotherapy rate increased (from 76.4% in 1981–1983 to 91.7% in 1993–1994, P = 10–5) and mediastinal irradiation decreased (to roughly 25% of patients after 1983). Median survival time increased for the overall population from 6.6 months in 1981–1983 to 11.3 months in 1993–1994 (P = 10–5), for patients with limited disease (LD) from 9.2 (P = 0.002) months to 14.0 months, and for those with extensive (ED) disease from 3.5 months to 9.6 months (P = 10–5). Significant independent prognostic factors were disease extent, clinical trial participation, period, type of chemotherapy, and mediastinal irradiation in LD. Survival time has truly improved as ‘state of the art’ management of SCLC has changed. © 2001 Cancer Research Campaign http://www.bjcancer. com
D-branes, Matrix Theory and K-homology

In this paper, we study a new matrix theory based on non-BPS D-instantons in type-IIA string theory and D-instanton--anti D-instanton system in type-IIB string theory, which we call K-matrix theory. The theory correctly incorporates the creation and annihilation processes of D-branes. The configurations of the theory are identified with spectral triples, which are the noncommutative generalization of riemannian geometry a la Connes, and they represent the geometry on the world-volume of higher dimensional D-branes. Remarkably, the configurations of D-branes in the K-matrix theory are naturally classified by a K-theoretical version of homology group, called K-homology. Furthermore, we argue that the K-homology correctly classifies the D-brane configurations from a geometrical point of view. We also construct the boundary states corresponding to the configurations of the K-matrix theory, and explicitly show that they represent the higher dimensional D-branes.
Trends in Blood Pressure and Hypertension Detection, Treatment, and Control 1980 to 2009: The Minnesota Heart Survey

Background— Hypertension is common and treatable, but detection and control remain a major health challenge. This study sought to determine population trends in blood pressure and in the control of hypertension in the Minneapolis/St. Paul area (2010 population, 2.85 million) from 1980 to 2009. Methods and Results— Surveys of risk factors were performed every 5 years among randomly selected adults aged 25 to 74 years. Data on hypertension knowledge and use of medications were collected by interview. Blood pressure was measured by standardized methods, with hypertension defined as blood pressure ≥140 mm Hg systolic and/or 90 mm Hg diastolic or controlled at <140 and/or 90 mm Hg with medications. Six surveys included 11 192 men and 12 795 women. Mean systolic blood pressure fell from 124.9 mm Hg in 1980 to 1982 to 121.1 mm Hg in 2007 to 2009 for men (P<0.0001) and from 120.1 to 114.7 mm Hg for women (P<0.0001). Similar trends for diastolic blood pressure were observed. The percentage of adults with uncontrolled blood pressure (≥140 and/or 90 mm Hg) with or without medication use fell from 20.3% to 5.8% (P<0.001) for men and from 13.1% to 2.7% (P<0.0001) for women. Antihypertensive medication use rose to >50% among all adults aged 55 to 74 years. Sixty-six percent of men and 72% of women with hypertension had their hypertension treated or controlled by 2007 to 2009. A majority of the decline in mean population blood pressure was the result of control with aggressive use of antihypertensive drugs. Stroke mortality in this population fell in parallel. Conclusions— The rate of hypertension detection and control in this community is among the highest observed in a US population and already exceeds Healthy People 2020 goals.
Detection of HIV-1 sequences in intestinal bacteria of HIV/AIDS patients.

OBJECTIVES Bacterial DNA isolated from the intestinal tract of 11 American and 30 Slovak HIV/AIDS patients were analyzed by colony and dot blot hybridization assay for HIV-1 specific sequences. Secondly, PCR using primers specific for the HIV-1 gag, pol and env genes for detection of HIV-1 sequences in these DNA were performed. RESULTS Intestinal bacteria DNA of HIV/AIDS patients hybridized in colony and dot blot hybridization assay for HIV-1 specific sequences. PCR products synthesized on specific primers of HIV-1 gag (115 bp), env (142 bp), pol-env (1484) genes were found to be for more than 90% homologous to the corresponding sequence in HIV-1. CONCLUSIONS Intestinal bacteria of HIV/AIDS patients are bearing sequences for more than 90% identical with those of HIV-1.
T‐structures and torsion pairs in a 2‐Calabi–Yau triangulated category

For a d‐Calabi–Yau triangulated category 𝒷 with a d‐cluster tilting subcategory 𝒯, the decomposition of 𝒷 is determined by the decomposition of 𝒯 satisfying ‘vanishing condition’ of negative extension groups, namely, 𝒷=⊕i∈I𝒷i, where 𝒷i, i∈I, are triangulated subcategories, if and only if 𝒯=⊕i∈I𝒯i, where 𝒯i, i∈I, are subcategories with Hom𝒷(𝒯i[t], 𝒯j)=0, ∀ 0⩽t⩽d−2 and i≠j. This induces that for any two cluster tilting objects T and T′ in a 2‐Calabi–Yau triangulated category 𝒷, the Gabriel quiver of the endomorphism algebra End𝒷T is connected if and only if so is that of End𝒷T′. As an application, we prove that the indecomposable 2‐Calabi–Yau triangulated categories with cluster tilting objects have no non‐trivial t‐structures and no non‐trivial co‐t‐structures. This allows us to give a classification of torsion pairs in those triangulated categories, and to determine further the hearts of torsion pairs in the sense of Nakaoka, which are equivalent to the module categories over the endomorphism algebras of the cores of the torsion pairs. We also discuss the relationship between mutations of torsion pairs and mutations of cluster tilting objects.
ERP Evidence for Cross-Modal Audiovisual Effects of Endogenous Spatial Attention within Hemifields

Previous ERP studies have uncovered cross-modal interactions in endogenous spatial attention. Directing attention to one side to judge stimuli from one particular modality can modulate early modality-specific ERP components not only for that modality, but also for other currently irrelevant modalities. However, past studies could not determine whether the spatial focus of attention in the task-irrelevant secondary modality was similar to the primary modality, or was instead diffuse across one hemifield. Here, auditory or visual stimuli could appear at any one of four locations (two on each side). In different blocks, subjects judged stimuli at only one of these four locations, for an auditory (Experiment 1) or visual (Experiment 2) task. Early attentional modulations of visual and auditory ERPs were found for stimuli at the currently relevant location, compared with those at the irrelevant location within the same hemifield, thus demonstrating within-hemifield tuning of spatial attention. Crucially, this was found not only for the currently relevant modality, but also for the currently irrelevant modality. Moreover, these within-hemifield attention effects were statistically equivalent regardless of the task relevance of the modality, for both the auditory and visual ERP data. These results demonstrate that within-hemifield spatial attention for one task-relevant modality can transfer cross-modally to a task-irrelevant modality, consistent with spatial selection at a multimodal level of representation.
Child well-being in single-mother families.

OBJECTIVES Children from single-mother families are at increased risk of psychosocial morbidity. This article examines the strength of association between single-mother family status and child outcome, both alone and controlling for other sociodemographic and personal (maternal/family) variables. METHOD Data from the Canadian National Longitudinal Survey of Children and Youth Cycle 1 (1994-1995) were used. Children aged 6 to 11 years in single-mother and two-parent families were included (n = 9,398). Child functioning measures included social impairment, psychiatric problems, and math score. RESULTS Single-mother family status on its own is a significant predictor of all child difficulties, but the explained variance is limited and the effect size decreases when other variables known to influence child functioning are included. Household income, a sociodemographic variable, is inversely associated with social impairment and positively associated with math score. Hostile parenting and maternal depression are the personal variables most strongly associated with social impairment and psychiatric problems. Children in single-mother families where there is hostile parenting are at significantly increased risk of psychiatric problems. CONCLUSIONS The results suggest that children from single-mother families develop difficulties for the same reasons as children from two-parent families. Specific interventions for single-mother families may be warranted in the areas of parenting and other areas of concentrated risk.