Miracle-dz/UniFAR-FTUs huggingface dataset:
Complexities and uncertainties of neuronal network function

The nervous system generates behaviours through the activity in groups of neurons assembled into networks. Understanding these networks is thus essential to our understanding of nervous system function. Understanding a network requires information on its component cells, their interactions and their functional properties. Few networks come close to providing complete information on these aspects. However, even if complete information were available it would still only provide limited insight into network function. This is because the functional and structural properties of a network are not fixed but are plastic and can change over time. The number of interacting network components, their (variable) functional properties, and various plasticity mechanisms endows networks with considerable flexibility, but these features inevitably complicate network analyses. This review will initially discuss the general approaches and problems of network analyses. It will then examine the success of these analyses in a model spinal cord locomotor network in the lamprey, to determine to what extent in this relatively simple vertebrate system it is possible to claim detailed understanding of network function and plasticity.
Quality optimisation in colonoscopy: a function of time of colonoscopy or bowel preparation

To test the hypothesis claimed in recent studies that quality of bowel preparation for colonoscopy could be influenced by the time of the day colonoscopy is performed. Do patients in morning list have better bowel preparation than those on the afternoon list? Retrospective analysis of 736 consecutive patients who had colonoscopy from 1st August to 31st December 2012. Patients with poor bowel preparation (Boston Bowel Prep Score 6 or less) were identified (n = 242). Colonoscopy reports of these patients analysed. Patients were stratified into two groups (am and pm) and results compared. Mean patient age 63.9 years (range 19-89). Male to female ratio 1:1. 92% of patients were given Moviprep. for bowel preparation. 32.9% (242/736) of patients were identified as having inadequate bowel preparation. 37.7% of morning list patients had poor bowel preparation. 26.7% of afternoon list patients had poor bowel preparation. 14.7% (108/736) had incomplete colonoscopy, of which 26.9% (29/108) were due to poor bowel preparation. The commonest reasons for incomplete examination were patient discomfort & bowel looping. Our study demonstrates that morning session patients had poorer bowel preparation than the afternoon session patients in contrast to published evidence in recent literature. This implies that timing of bowel preparation is probably more important than timing of colonoscopy. Poor bowel preparation does not seem to have a significant impact on the colonoscopy failure rate in this series.
The Effects of Cultural Dissimilarity on Employee Job Attitudes and Productivity

The Effects of Cultural Dissimilarity on Employee Job Attitudes and Productivity by Sherrice Lyons MBA, Northern Caribbean University, 2005 BSc, Northern Caribbean University, 2003 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Industrial/Organizational Psychology Walden University May 2018
DynaMoth: Dynamic Code Synthesis for Automatic Program Repair

Automatic software repair is the process of automatically fixing bugs. The Nopol repair system repairs Java code using code synthesis. We have designed a new code synthesis engine for Nopol based on dynamic exploration, it is called DynaMoth. The main design goal is to be able to generate patches with method calls. We evaluate DynaMoth over 224 of the Defects4J dataset. The evaluation shows that Nopol with DynaMoth is capable of synthesizing patches and enables Nopol to repair new bugs of the dataset.
Workforce Effects and the Evolution of Complex Sociality in Wild Damaraland Mole Rats

Explaining the evolution of eusocial and cooperatively breeding societies demands that we understand the effects of workforce size on the reproductive success of breeders. This challenge has yet to be addressed in the family that arguably exhibits the most extreme outcomes of vertebrate social evolution, the African mole rats (Bathyergidae), leaving the ultimate causes of their many unusual adaptations open to debate. Here we report—using a 14-year field study of wild Damaraland mole rats, Fukomys damarensis—that workers appear to have strong but unusual effects on offspring. Groups with larger workforces exhibited substantially higher rates of offspring recruitment while maintaining high juvenile survival rates, relationships that may have favored the evolution of the delayed dispersal, cooperation, morphological specialization, and unusual patterns of longevity that characterize such societies. Offspring reared by larger workforces also showed slower growth, however. That reduced offspring growth in larger groups has also been documented under ad lib. food conditions in the laboratory raises the possibility that this reflects socially induced growth restraint rather than simple constraints on resource availability. Our findings shed new light on the evolution of complex sociality in this enigmatic clade and highlight further departures from the norms reported for other cooperative vertebrates.
A Hybrid DCT and DWT Color Image Watermarking in RGB Color Space

This paper presents a hybrid blind watermarking technique for color images based on DCT in wavelet transform. Advantages of two powerful transforms namely DCT and DWT are combined. Carrier image is first decomposed into 3 channels, namely R, G, B. Harr DWT is applied to Blue channel and HH band is selected for watermark insertion. HH band is divided into blocks of size 8×8. DCT is applied to each 8×8 sized block. Finally binary watermark bits are inserted into middle frequency coefficients by adjusting coefficients DCT(4,3) and DCT(5,2). Simulation results shows that the proposed technique is imperceptible as well as robust against wide variety of attacks like noise attacks and filtering attacks etc. It achieves PSNR as 66.26 dB and recovers watermark completely with NC value as 1. Results are compared with DCT watermarking algorithm, it is proved that hybrid watermarking results are better than implementing a single algorithm alone.
Analysis of voice stress in call centers conversations

This paper presents how voice stress is manifested in the acoustic and phonetic structure of the speech signa l. Out of few thousand authentic Police 997 emergency phon e calls, a few hundred were selected automatically according to their duration (dialogs shorter than 3-4 seconds were omi tted). Finally, 45 speakers were chosen for acoustic evalu ation, the basis for selection being a perceptual assessment. Basic statistical measurements for stressed and neut ral speech run over the database showed the relevance of the arousal dimension in stress processing. The MDVP analysis confirmed statistical significance of such parameters as fundamental frequency and pitch variation, noise -to harmonic-ratio, subharmonics and voice irregulariti es for stress detection. In case of highly stressful c onditions a systematic over-one-octave shift in pitch was obs erved. Linear Discriminant Analysis based on 9 acoustic fe atures showed it is possible to categorize the following c lasses: male – stressed and neutral, female stressed and neutral speech.
Site-Specific Assessments of the Abundance of Three Inshore Dolphin Species to Inform Conservation and Management

Assessing the abundance of wildlife populations is essential to their effective conservation and management. Concerns have been raised over the vulnerability of tropical inshore dolphins in waters off northern Australia to anthropogenic impacts on local populations, yet a lack of abundance data precludes assessment of their conservation status and the management of threats. Using small vessels as cost-effective research platforms, photo-identification surveys and capture-recapture models were applied to provide the first quantitative abundance data for Australian snubfin (Orcaella heinsohni), Australian humpback (Sousa sahulensis), and Indo-Pacific bottlenose dolphins (Tursiops aduncus) at five sites in the Kimberley region of north-western Australia. The abundance of each species was highly variable between different sites, likely reflecting species-specific habitat preferences. Within the c. 130 km2 study sites, the estimated abundance of most species was ≤ 60 individuals (excluding calves), and fewer than 20 humpback dolphins were identified at each site in any one 3-5 week sampling period. However, larger estimates of c. 130 snubfin and c. 160 bottlenose dolphins were obtained at two different sites. Several local populations showed evidence of site fidelity, particularly snubfin dolphins. By implementing a standardized, multi-site approach, data on local populations were provided within a broader, regional context, and indicated that each species is patchily distributed in the region. This highlights the need for site-specific baseline data collection using appropriate survey techniques to quantitatively assess the potential impacts of threatening activities to local populations. These findings further illustrate the need to gain a greater understanding of known and potential threats to inshore dolphin populations, their relative impacts, and to mitigate where necessary. In particular, the level of interactions with inshore gillnet fisheries requires urgent assessment. An ideal candidate site for a long-term study of snubfin dolphin population dynamics is identified, where trends in abundance and their influencing factors could be investigated. The methods employed herein provide an example of rigorous, site-specific population assessments of inshore dolphins that are broadly applicable to such studies elsewhere.
Developing a conceptual framework for the co-operative and mutual enterprise business model

Abstract The co-operative and mutual enterprise business model represents a unique type of organisation that has a dual purpose focused on both economic and social goals. For nearly two centuries it has played an important role in economic development, job creation and addressing market failures. However, despite its potential importance to economic development it has been largely ignored within the mainstream economics and management literature. This paper provides an overview of the nature of the co-operative and mutual enterprise business model and also proposes a business model framework or ‘canvas’ that can be used for research, teaching and strategic analysis.
Anomaly analysis for Physical Access Control security configuration

Physical Access Controls, such as supervised doors, surveillance cameras and alarms, act as important points of demarcation between physical zones (areas/rooms) of different levels of trust. They do so by controlling personnel flow to and from areas in accordance with the enterprise security policy. A significant challenge in providing physical access control for (restricted) areas is attaining a degree of confidence that a Physical Access Control security configuration adequately addresses the threats. A misconfiguration may result in a threat of unapproved personnel access or the denial of approved personnel access to a restricted zone. In practice, Physical Access Control security configurations typically span multiple zones, involve many users and run to many thousands of access-control rules, and such complexity may increase the likelihood of misconfiguration. In this paper, a formal model for Physical Access Control security configurations is presented. This model, implemented in SAT, captures a number of unique anomalies specific to Physical Access Control domain. A preliminary set of experiments that evaluate our approach is presented.
Comparative RNAi Screens in C. elegans and C. briggsae Reveal the Impact of Developmental System Drift on Gene Function

Although two related species may have extremely similar phenotypes, the genetic networks underpinning this conserved biology may have diverged substantially since they last shared a common ancestor. This is termed Developmental System Drift (DSD) and reflects the plasticity of genetic networks. One consequence of DSD is that some orthologous genes will have evolved different in vivo functions in two such phenotypically similar, related species and will therefore have different loss of function phenotypes. Here we report an RNAi screen in C. elegans and C. briggsae to identify such cases. We screened 1333 genes in both species and identified 91 orthologues that have different RNAi phenotypes. Intriguingly, we find that recently evolved genes of unknown function have the fastest evolving in vivo functions and, in several cases, we identify the molecular events driving these changes. We thus find that DSD has a major impact on the evolution of gene function and we anticipate that the C. briggsae RNAi library reported here will drive future studies on comparative functional genomics screens in these nematodes.
Changes in P3b Latency and Amplitude Reflect Expertise Acquisition in a Football Visuomotor Learning Task

Learning is not a unitary phenomenon. Rather, learning progresses through stages, with the stages reflecting different challenges that require the support of specific cognitive processes that reflect the functions of different brain networks. A theory of general learning proposes that learning can be divided into early and late stages controlled by corticolimbic networks located in frontal and posterior brain regions, respectively. Recent human studies using dense-array EEG (dEEG) support these results by showing progressive increases in P3b amplitude (an Event Related Potential with estimated sources in posterior cingulate cortex and hippocampus) as participants acquire a new visuomotor skill. In the present study, the P3b was used to track the learning and performance of participants as they identify defensive football formations and make an appropriate response. Participants acquired the task over three days, and P3b latency and amplitude significantly changed when participants learned the task. As participants demonstrated further proficiency with extensive training, amplitude and latency changes in the P3b continued to closely mirror performance improvements. Source localization results across all days suggest that an important source generator of the P3b is located in the posterior cingulate cortex. Results from the study support prior findings and further suggest that the careful analysis of covert learning mechanisms and their underlying electrical signatures are a robust index of task competency.
The Value of Unlabeled Data for Classification Problems

Recently, there has been increasing interest in using unlabeled data for classi(cid:12)cation. However, whether these unlabeled data are truly useful is still under debate. In order to have a better understanding of relevant issues, it is worthwhile to precisely formulate the problem and carefully analyze the value of unlabeled data under certain learning models. In this paper, we approach this problem from the statistical point of view, where we assume that a correct model of the underlying distribution is given. We demonstrate that Fisher information matrices can be used to judge the asymptotic value of unlabeled data. We apply this methodology to both \passive partially supervised learning" and \active learning", and draw conclusions from this analysis. Experiments will be provided to support our claims.
Test‐retest reliability of a new delay aversion task and executive function measures

Despite the wide adoption of measures of executive functions and motivational tendencies in studies of developmental disorders and child psychopathology, few studies have investigated their test-retest reliability. The present paper examines the reliability of a new measure of delay aversion, three measures of working memory, a response inhibition measure and a measure of dual task performance. The children, aged between 7 and 15 years, performed the tasks twice, with a 2-week period in between the sessions. Using a relatively conservative criterion, only the delay aversion task and one of the working memory measures (delayed response alternation) demonstrated satisfactory test-retest reliability. The other two working memory measures (sentence span and counting span) showed modest reliability. For the inhibition measure (stop task) the results were mixed, with poor to modest reliabilities obtained for the various derived measures. The dual task failed to demonstrate adequate test-retest reliability. These differential reliabilities need to be borne in mind when interpreting the results of studies using these measures. In particular the effect of low reliability on statistical power and the Type II error rate should be considered.
Effectiveness of paramedic practitioners in attending 999 calls from elderly people in the community: cluster randomised controlled trial

Objective To evaluate the benefits of paramedic practitioners assessing and, when possible, treating older people in the community after minor injury or illness. Paramedic practitioners have been trained with extended skills to assess, treat, and discharge older patients with minor acute conditions in the community. Design Cluster randomised controlled trial involving 56 clusters. Weeks were randomised to the paramedic practitioner service being active (intervention) or inactive (control) when the standard 999 service was available. Setting A large urban area in England. Participants 3018 patients aged over 60 who called the emergency services (n=1549 intervention, n=1469 control). Main outcome measures Emergency department attendance or hospital admission between 0 and 28 days; interval from time of call to time of discharge; patients' satisfaction with the service received. Results Overall, patients in the intervention group were less likely to attend an emergency department (relative risk 0.72, 95% confidence interval 0.68 to 0.75) or require hospital admission within 28 days (0.87, 0.81 to 0.94) and experienced a shorter total episode time (235 v 278 minutes, 95% confidence interval for difference −60 minutes to −25 minutes). Patients in the intervention group were more likely to report being highly satisfied with their healthcare episode (relative risk 1.16, 1.09 to 1.23). There was no significant difference in 28 day mortality (0.87, 0.63 to 1.21). Conclusions Paramedics with extended skills can provide a clinically effective alternative to standard ambulance transfer and treatment in an emergency department for elderly patients with acute minor conditions. Trial registration ISRCTN27796329.
Descriptive Analysis and Meta Analysis of Studies Investigating the Effectiveness of Simultaneous Prompting Procedure

Researchers have investigated the simultaneous prompting (SP) procedure across three decades; however, no meta-analysis has been conducted. In the present systematic review, we conducted both a descriptive and meta-analysis of SP studies from a seminal publication of an SP study through 2017. Our search resulted in 20 studies published in English in internationally disseminated peer-reviewed journals that used single-case methodology and also met criteria for methodological rigor. To analyze effect sizes, we used percentage of non-overlapping points and Tau-U, with both revealing highly consistent results. We concluded that there is a substantial body of evidence to support the SP procedure to teach a variety of skills to individuals with disabilities when consistent parameters of the procedure are employed; however, future research is needed to specifically validate the procedure as effective in regard to specific types of disability (e.g., autism spectrum disorder) and specific types of tasks.
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro- beta-NGF in vivo

Extracts from BSC-40 cells infected with vaccinia recombinants expressing either the yeast KEX2 prohormone endoprotease or a human structural homologue (fur gene product) contained an elevated level of a membrane-associated endoproteolytic activity that could cleave at pairs of basic amino acids (-LysArg- and -ArgArg-). The fur-directed activity (furin) shared many properties with Kex2p including activity at pH 7.3 and a requirement for calcium. By using antifurin antibodies, immunoblot analysis detected two furin translation products (90 and 96 kD), while immunofluorescence indicated localization to the Golgi apparatus. Coexpression of either Kex2p or furin with the mouse beta- nerve growth factor precursor (pro-beta-NGF) resulted in greatly enhanced conversion of the precursor to mature nerve growth factor. Thus, the sequence homology shared by furin and the yeast KEX2 prohormone processing enzyme is reflected by significant functional homology both in vitro and in vivo.
Evidence for Use of a Psychometric Inventory of New College Student Adjustment with Ghanaian Students: Implications for the Professional Globalization of Counseling.

As the counseling profession continues its globalization onto Ghanaian college campuses, there is an increased need for psychometric assessments that support programming and interventions that promote degree matriculation and general student well-being. A sample of 696 young adult Ghanaian college students completed the Inventory of New College Student Adjustment (INCA) and related measures to estimate evidence of internal structure and relationships with conceptually related constructs. Confirmatory factor analyses were completed and inspection of fit indices revealed strong evidence for internal structure, and bivariate correlations indicated statistically significant positive associations with related medium effect sizes between the INCA subscales (Supportive Network and Belief in Self) and related measures. Implications for use of the INCA to support the professional activities of Ghanaian counselors working on college campuses are provided.
Inverse expression of somatostatin and CXCR4 chemokine receptors in gastroenteropancreatic neuroendocrine neoplasms of different malignancy

Introduction Somatostatin receptors (SSTR) are widely distributed in well-differentiated neuroendocrine neoplasms (NEN) and serve as primary targets for diagnostics and treatment. An overexpression of the chemokine receptor CXCR4, in contrast, is considered to be present mainly in highly proliferative and advanced tumors. Comparative data are still lacking, however, for neuroendocrine carcinomas (NEC). Methods SSTR subtype (1, 2A, 3, 5) and CXCR4 expression was evaluated in G1 (n = 31), G2 (n = 47), and low (G3a; Ki-67: 21–49%; n = 21) and highly proliferative (G3b; Ki-67: >50%, n = 22) G3 (total n = 43) gastroenteropancreatic NEN samples by performing immunohistochemistry with monoclonal rabbit anti-human anti-SSTR and anti-CXCR4 antibodies, respectively, and was correlated with clinical data. Results Both CXCR4 and SSTR were widely expressed in all tumors investigated. CXCR4 expression differed significantly between the G1 and G3 specimens and within the G3 group (G3a to G3b), and was positively correlated with Ki-67 expression. SSTR2A, in contrast, exhibited an inverse association with Ki-67. SSTR2A was highly expressed in G1 and G2 tumors, but was significantly less abundant in G3 carcinomas. Additionally, SSTR1 expression was higher in G3a than in G3b tumors. Conclusion We observed an elevation in CXCR4 and a decrease in SSTR2A expression with increasing malignancy. Interestingly, 23% of the G3 specimens had strong SSTR2A expression. Because CXCR4 was strongly expressed in highly proliferative G3 carcinomas, it is an interesting new target and needs to be validated in larger studies.