Miracle-dz/UniFAR-FTUs huggingface dataset:
Music tonality and context-dependent recall: The influence of key change and mood mediation

Music in a minor key is often claimed to sound sad, whereas music in a major key is typically viewed as sounding cheerful. Such claims suggest that maintaining or switching the tonality of a musical selection between information encoding and retrieval should promote robust “mood-mediated” context-dependent memory (CDM) effects. The reported experiment examined this hypothesis using versions of a Chopin waltz where the key was either reinstated or switched at retrieval, so producing minor–minor, major–major, minor–major, and major–minor conditions. Better word recall arose in reinstated-key conditions (particularly for the minor–minor group) than in switched-key conditions, supporting the existence of tonality-based CDM effects. The tonalities also induced different mood states. The minor key induced a more negative mood than the major key, and participants in switched-key conditions demonstrated switched moods between learning and recall. Despite the association between music tonality and mood, a path analysis failed to reveal a reliable mood-mediation effect. We discuss why mood-mediated CDM may have failed to emerge in this study, whilst also acknowledging that an alternative “mental-context” account can explain our results (i.e., the mental representation of music tonality may act as a contextual cue that elicits information retrieval).
The Independent cue and cusSystems Confer Copper Tolerance during Aerobic and Anaerobic Growth inEscherichia coli *

Copper is essential but can be toxic even at low concentrations. Coping with this duality requires multiple pathways to control intracellular copper availability. Three copper-inducible promoters, controlling expression of six copper tolerance genes, were recently identified in Escherichia coli. The cue system employs an inner membrane copper transporter, whereas the cus system includes a tripartite transporter spanning the entire cell envelope. Although cusis not essential for aerobic copper tolerance, we show here that a copper-sensitive phenotype can be observed when cus is inactivated in a cueR background. Furthermore, a clear copper-sensitive phenotype for the cus system is revealed in the absence of O2. These results indicate that thecue pathway, which includes a copper exporter, CopA, and a periplasmic oxidase, CueO, is the primary aerobic system for copper tolerance. During anaerobic growth, however, copper toxicity increases, and the independent cus copper exporter is also necessary for full copper tolerance. We conclude that the cytosolic (CueR) and periplasmic (CusRS) sensor systems differentially regulate copper export systems in response to changes in copper and oxygen availability. These results underscore the increased toxicity of copper under anaerobic conditions and the complex adaptation of copper export in E. coli.
On the expected total number of infections for virus spread on a finite network

In this paper we consider a simple virus infection spread model on a finite population of n agents connected by some neighborhood structure. Given a graph G on n vertices, we begin with some fixed number of initial infected vertices. At each discrete time step, an infected vertex tries to infect its neighbors with probability � 2 (0,1) independently of others and then it dies out. The process continues till all infected vertices die out. We focus on obtaining proper lower bounds on the expected number of ever infected vertices. We obtain a simple lower bound, using breadth-first search algorithm and show that for a large class of graphs which can be classified as the ones which locally “look like” a tree in sense of the local weak convergence [1], this lower bound gives better approximation than some of the known approximations through matrix-method based upper bounds [3]. AMS 2000 Subject Classifications: Primary: 60K35, 05C80; secondary: 60J85, 90B15
Improving the efficiency of genomic selection

Abstract We investigate two approaches to increase the efficiency of phenotypic prediction from genome-wide markers, which is a key step for genomic selection (GS) in plant and animal breeding. The first approach is feature selection based on Markov blankets, which provide a theoretically-sound framework for identifying non-informative markers. Fitting GS models using only the informative markers results in simpler models, which may allow cost savings from reduced genotyping. We show that this is accompanied by no loss, and possibly a small gain, in predictive power for four GS models: partial least squares (PLS), ridge regression, LASSO and elastic net. The second approach is the choice of kinship coefficients for genomic best linear unbiased prediction (GBLUP). We compare kinships based on different combinations of centring and scaling of marker genotypes, and a newly proposed kinship measure that adjusts for linkage disequilibrium (LD). We illustrate the use of both approaches and examine their performances using three real-world data sets with continuous phenotypic traits from plant and animal genetics. We find that elastic net with feature selection and GBLUP using LD-adjusted kinships performed similarly well, and were the best-performing methods in our study.
Biased Listing in Electronic Marketplaces - Evidence from the Online Hotel Distribution

In this study we investigate the phenomenon of biased listing. Biased listing describes the practice of listing items in search engines or market platforms according to criteria other than the normally expected ones (e.g. relevance or quality). We were able to access real booking data from the hotel distribution platform provider Hotel.de. Hotel.de offers different contract types that have a direct impact on the ranking of hotels in the search results pages presented to customers. By carrying out comparisons of hotel bookings before and after switching contract types we are able to show that biased listing has a significant impact on the number of bookings a hotel is able to draw from the platform. Our findings have implications for the market participants. For example, market providers, by engaging in practices of biased listing, are able to exploit their gatekeeper position by making hotels compete for listing positions on the platform.
Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

Cell membrane receptors rarely work on isolation, often they form oligomeric complexes with other receptor molecules and they may directly interact with different proteins of the signal transduction machinery. For a variety of reasons, rhodopsin-like class A G-protein-coupled receptors (GPCRs) seem an exception to the general rule of receptor–receptor direct interaction. In fact, controversy surrounds their potential to form homo- hetero-dimers/oligomers with other class A GPCRs; in a sense, the field is going backward instead of forward. This review focuses on the convergent, complementary and telling evidence showing that homo- and heteromers of class A GPCRs exist in transfected cells and, more importantly, in natural sources. It is time to decide between questioning the occurrence of heteromers or, alternatively, facing the vast scientific and technical challenges that class A receptor-dimer/oligomer existence pose to Pharmacology and to Drug Discovery.
Mobbing at banks: Moderating Effect of Negative Emotions on the Relationship between Mobbing and Turnover Intention

While it is not always possible to prevent mobbing in organizations, individuals can be empowered to cope with it by regulating emotions. The purpose of this study was to explore mobbing and turnover intention in banking sector and to examine the moderating effect of negative emotions. Survey approach and free association technique were used with participants who were 164 bank employees in Istanbul, Turkey. Findings revealed that prevalence of mobbing is 30%. The most frequent aggressive behaviors are threats to individual's personal and work reputation. As the environment is perceived more negative, perceived mobbing increases. With the high levels of mobbing negative emotions increase and turnover intentions arise. Negative emotions moderated the relationship between mobbing and turnover intention. Employees with high negative emotions showed more turnover intention when mobbing increased. Effective coping with mobbing is essential for individuals and organizations since it increases negative affect and turnover intentions in employees. This findings also underlines the importance of anti-bullying policies. To our knowledge, this paper examined the moderating effect of negative emotions on the relationship between mobbing and turnover for the first time.
Comparing species richness among assemblages using sample units: why not use extrapolation methods to standardize different sample sizes?

Comparisons of species richness among assemblages using different sample sizes may produce erroneous conclusions due to the strong positive relationship between richness and sample size. A current way of handling the problem is to standardize sample sizes to the size of the smallest sample in the study. A major criticism about this approach is the loss of information contained in the larger samples. A potential way of solving the problem is to apply extrapolation techniques to smaller samples, and produce an estimated species richness expected to occur if sample size were increased to the same size of the largest sample. We evaluated the reliability of 11 potential extrapolation methods over a range of different data sets and magnitudes of extrapolation. The basic approach adopted in the evaluation process was a comparison between the observed richness in a sample and the estimated richness produced by estimators using a sub-sample of the same sample. The Log-Series estimator was the most robust for the range of data sets and sub-sample sizes used, followed closely by Negative Binomial, SO-J1, Logarithmic, Stout and Vandermeer, and Weibull estimators. When applied to a set of independently replicated samples from a species-rich assemblage, 95% confidence intervals of estimates produced by the six best evaluated methods were comparable to those of observed richness in the samples. Performance of estimators tended to be better for species-rich data sets rather than for those which contained few species. Good estimates were found when extrapolating up to 1.8-2.0 times the size of the sample. We suggest that the use of the best evaluated methods within the range of indicated conditions provides a safe solution to the problem of losing information when standardizing different sample sizes to the size of the smallest sample.
The Use of Language to Disempower: Two Related Studies of Women in Sri Lanka

The rise of economic liberalism in Sri Lanka in the latter half of the twentieth century has generated a continuous, powerful, and controversial debate about women in the workforce. Local politicians and powerful societal forces have used discourse to display power in the media and wider society. Gender issues were used as a platform to engage in unrelated political agendas and criticize export processing zones (EPZs), female workers, and female sexuality. Our research in Sri Lanka sampled more than 4,000 women over 14 years. The article uses data from two research studies from 2008–2011 (Study 1) and from 2013–2014 (Study 2) in Sri Lanka. The studies are interrelated. Each analyse the levels of empowerment and disempowerment experienced by women, due specifically to the negative discourse they faced on a daily basis – both as part of their life as EPZ workers (study 1) and after returning to their villages (Study 2). Serious pieces of negative discourse stand out as examples of misleading speech and attempt to subjugate women through power. Our interviews with Sri Lankan EPZ workers show that young women are described as Juki girls, a pejorative term used with a negative connotation. Moreover, EPZs are often referred to as whore zones or love zones due to the stigma created by society and pushed by a political agenda in national political discourse, such as: “Our innocent girls are sewing underwear for white women” (Lynch, 2002, p. 82). The questions in both studies were designed to assess the respondents’ experiences of power (or powerlessness) and empowerment. Study 1 shows that nearly all of the women surveyed (95.3 percent) reported feeling empowered as a result of their work in EPZs. The respondents also indicated empowerment across their home as well. However, societal level disempowerment was significant, much of it emanating in the public arena and in societal and political resistance to EPZ workers. Concurrently, results of Study 2 demonstrated lower but significant negative experiences as a result of work in formal manufacturing. Less than 10 percent (7.2 percent) experienced humiliation in public, their community or society while working in the manufacturing industry, and only 12 percent reported experiencing negative societal attitudes upon first returning home from their work in EPZs.
Gowers norms for the Thue-Morse and Rudin-Shapiro sequences

We estimate Gowers uniformity norms for some classical automatic sequences, such as the Thue-Morse and Rudin-Shapiro sequences. The methods can also be extended to other automatic sequences. As an application, we asymptotically count arithmetic progressions in the set of integers $\leq N$ where the Thue-Morse (resp. Rudin-Shapiro) sequence takes the value $+1$.
Directing our own careers, but getting help from empowering leaders

Purpose The purpose of this paper is to examine the potential effects of empowering leadership on followers’ subjective career success through psychological empowerment, protean career orientation, and career commitment. Design/methodology/approach Full-time employees working in the USA were recruited through Amazon’s Mechanical Turk. Participants answered surveys at three separate points over a six-week period (n=261). Structural equation modeling and bootstrapping were used to verify the indirect effect of empowering leadership on career satisfaction controlling for common method variance and growth need strength. Findings Empowering leadership was positively related to followers’ subsequent psychological empowerment, which in turn predicted protean career attitudes and career commitment, but only career commitment had a significant relationship with career satisfaction. Research limitations/implications Empowering leadership behaviors focus on potentially career-enhancing factors, including providing followers with the confidence, inspiration, and authority to assume control of their work lives. Empowering leaders benefit their followers’ careers, and psychological empowerment and career commitment may be important mechanisms in the empowering leadership-career success relationship when their effects are considered simultaneously. Employees’ development of a protean career orientation has less direct effect on subjective career success than simple commitment to a career. Originality/value Empowering leadership has been overlooked in career literature. The findings advance the understanding of how empowering leader behaviors could help employees’ subjective career success in a serial mediation model. Additionally, the study empirically demonstrates that psychologically empowered employees are more likely to engage in protean career actions and navigate their own career goals.
A defaultable HJM multiple-curve term structure model

In the aftermath of the 2007‐09 financial crisis, a variety of spreads have developed between quantities that had been essentially the same until then, notably LIBOR-OIS spreads, LIBOR-OIS swap spreads, and basis swap spreads. In this paper we study the valuation of LIBOR interest rate derivatives in a multiple-curve setup, which accounts for a discrepancy between a risk-free discount curve and a LIBOR fixing curve. Toward this end we resort to a defaultable HJM methodology, in which this discrepancy is modeled by an implied default intensity of the LIBOR contributing banks.
WFC3 TV2 Testing: IR Gain Results

Over the course of Thermal Vacuum 2 (TV2) testing during the summer of 2007, we obtained several datasets that allowed us to calculate the gain of the IR1 (FPA129) detector. At the nominal flight gain setting of 2.0 e - /ADU, we measure gain values between 2.12 ‐ 2.16 e - /ADU, after accounting for inter-pixel capacitance (IPC). This corresponds to 2.41 ‐ 2.45 e - /ADU before the IPC correction. For the other (unsupported) gain settings of 2.5, 3.0, and 4.0 e - /ADU, we calculate actual gain values of 2.78 ‐ 2.88, 3.33 ‐ 3.48, and 4.50 ‐ 4.76 e - /ADU respectively, after IPC correction.
All three RNA recognition motifs and the hinge region of HuC play distinct roles in the regulation of alternative splicing

The four Hu [embryonic lethal abnormal vision-like (ELAVL)] protein family members regulate alternative splicing by binding to U-rich sequences surrounding target exons and affecting the interaction of the splicing machinery and/or local chromatin modifications. Each of the Hu proteins contains a divergent N-terminus, three highly conserved RNA recognition motifs (RRM1, RRM2 and RRM3) and a hinge region separating RRM2 and RRM3. The roles of each domain in splicing regulation are not well understood. Here, we investigate how HuC, a relatively poorly characterized family member, regulates three target pre-mRNAs: neurofibromatosis type I, Fas and HuD. We find that the HuC N-terminus is dispensable for splicing regulation, and the three RRMs are required for splicing regulation of each target, whereas the hinge region contributes to regulation of only some targets. Interestingly, the regions of the hinge and RRM3 required for regulating different targets only partially overlap, implying substrate-specific mechanisms of HuC-mediated splicing regulation. We show that RRM1 and RRM2 are required for binding to target pre-mRNAs, whereas the hinge and RRM3 are required for HuC–HuC self-interaction. Finally, we find that the portions of RRM3 required for HuC–HuC interaction overlap with those required for splicing regulation of all three targets, suggesting a role of HuC–HuC interaction in splicing regulation.
Relevance of fruits, vegetables and flavonoids from fruits and vegetables during early life, mid-childhood and adolescence for levels of insulin-like growth factor (IGF-1) and its binding proteins IGFBP-2 and IGFBP-3 in young adulthood

Abstract The growth hormone (GH) insulin-like growth factor (IGF) axis has been linked to insulin metabolism and cancer risk. Experimental evidence indicates that the GH–IGF axis itself can be influenced by dietary flavonoids. As fruit and vegetable (FV) intake is a major source of flavonoid consumption, FV’s beneficial health effects may be explained via flavonoids’ influence on the GH–IGF axis, but observational evidence is currently rare. We used data from Dortmund Nutritional and Anthropometric Longitudinally Designed Study participants to analyse prospective associations between FV, fruit intake and flavonoid intake from FV (FlavFV) with IGF-1 and its binding proteins IGFBP-2 and IGFBP-3. Subjects needed to provide a fasting blood sample in adulthood (18–39 years) and at least two 3-d weighed dietary records in early life (0·5−2 years, n 191), mid-childhood (3−7 years, n 265) or adolescence (girls: 9−15 years, boys: 10−16 years, n 261). Additional analyses were conducted among those providing at least three 24-h urine samples in adolescence (n 236) to address the predictor urinary hippuric acid (HA), a biomarker of polyphenol intake. Higher fruit intake in mid-childhood and adolescence was related to higher IGFBP-2 in adulthood (P=0·03 and P=0·045). Comparable trends (P=0·045−0·09) were discernable for FV intake (but not FlavFV) in all three time windows. Similarly, higher adolescent HA excretion tended to be related (P=0·06) to higher adult IGFBP-2 levels. Regarding IGFBP-3, a marginal (P=0·08) positive association was observed with FlavFV in mid-childhood only. None of the investigated dietary factors was related to IGF-1. In conclusion, higher fruit and FV intakes during growth may be relevant for adult IGFBP-2, but probably not for IGFBP-3 or IGF-1.
Alexithymia influences craving through facets of emotion regulation in alcoholic patients

ABSTRACT There is evidence that alexithymia is related to alcohol problems. However, no study has been conducted to show whether emotion regulation (ER) subscales such as reappraisal and suppression mediate the relationship between alexithymia and craving. The aim of this study was to evaluate the effects of ER subscales (i.e., reappraisal and suppression) as mediators on the relationships between alexithymia and subscales of craving (i.e., obsessive and compulsive subscales). A total of 205 alcoholic outpatients completed the Farsi version of the Toronto Alexithymia Scale (FTAS-20), the Emotion Regulation Questionnaire (ERQ), the Obsessive Compulsive Drinking Scale (OCDS), the Alcohol Use Disorders Identification Test (AUDIT), and the Beck Depression Inventory-II (BDI-II). Results revealed that alexithymia indirectly influenced obsessive and compulsive cravings through both paths of ER decreased reappraisal and increased suppression subscales. Also, the relations of alexithymia to obsessive and compulsive cravings through the mediation pathway of decreased reappraisal were stronger than the path of suppression. It was concluded that low reappraisal and high suppression seem to be important in predicting obsessive and compulsive cravings for alcoholics with alexithymia. This suggests that the efforts based on increasing reappraisal and decreasing suppression may be important in reducing craving in alcoholic patients.
Dopamine D1/D5 Receptors Contribute to De Novo Hippocampal LTD Mediated by Novel Spatial Exploration or Locus Coeruleus Activity

The neurons of the locus coeruleus (LC) fire in response to novelty, and LC activation coupled with hippocampal afferent stimulation leads to long-term depression (LTD). The encoding of novel spatial information also involves activation of dopamine D1/D5 receptors. It is unclear if, or how, the noradrenergic and dopaminergic systems interact mechanistically in processing novelty. Novel spatial exploration when coupled with Schaffer collateral (SC) test-pulse stimulation results in short-term depression at SC-CA1 synapses, which is not observed in the absence of afferent stimulation. However, activation of D1/D5 receptors under these conditions without concomitant afferent stimulation enables slow-onset depression. LTD (>24 h) is facilitated when novel exploration occurs concurrently with low-frequency stimulation of CA1. Effects are not improved by a D1/D5 agonist. Facilitation of LTD (>4 h) by coupling LC stimulation with CA1 test-pulse stimulation was blocked by a D1/D5 antagonist, however, as was habituation to the holeboard environment. Novel spatial learning during LC stimulation did not enhance LTD further, whereas D1/D5 agonist treatment enabled LTD to persist for over 24 h. These data suggest that the regulation of hippocampal LTD by the LC is supported by D1/D5 receptors and that their contribution to information storage becomes important when the thresholds for persistent LTD have not been reached.