Miracle-dz/UniFAR-FTUs huggingface dataset:
Platelet Count and Mean Platelet Volume at the Time of and After Acute Myocardial Infarction

Platelet count has been shown to be lower and mean platelet volume (MPV) to be higher in acute myocardial infarction (MI). However, it is not known whether these changes persist post-MI or if these measures are able to distinguish between acute thrombotic and non-thrombotic MI. Platelet count and MPV were measured in 80 subjects with acute MI (thrombotic and non-thrombotic) and stable coronary artery disease (CAD) at cardiac catheterization (acute phase) and at >3-month follow-up (quiescent phase). Subjects were stratified using stringent clinical, biochemical, histological, and angiographic criteria. Outcome measures were compared between groups by analysis of variance. Forty-seven subjects met criteria for acute MI with clearly defined thrombotic (n = 22) and non-thrombotic (n = 12) subsets. Fourteen subjects met criteria for stable CAD. No significant difference was observed in platelet count between subjects with acute MI and stable CAD at the acute or quiescent phase. MPV was higher in acute MI (9.18 ± 1.21) compared to stable CAD (8.13 ± 0.66; P = 0.003) at the acute phase but not at the quiescent phase (8.48 ± 0.58 vs 8.94 ± 1.42; P = 0.19). No difference in platelet count or MPV was detected between thrombotic and non-thrombotic subsets at acute or quiescent phases. The power to detect differences in these measures between thrombotic and non-thrombotic subsets was 58%. Higher MPV at the time of acute MI is not observed by 3 months post-MI (quiescent phase). Platelet count and MPV do not differ in subjects with thrombotic versus non-thrombotic MI. Further investigation is warranted to evaluate the utility of these measures in the diagnosis of acute MI.
International Transfer Pricing and Tax Avoidance: Evidence from the Linked Tax-Trade Statistics in the UK

This paper employs unique data on export transactions and corporate tax returns of UK multinational firms and finds that firms manipulate their transfer prices to shift profits to lower-taxed destinations. It uncovers three new findings on tax-motivated transfer mispricing in real goods. First, transfer mispricing increases substantially when taxation of foreign profits changes from a worldwide to a territorial approach in the UK, with multinationals shifting more profits into low-tax jurisdictions. Second, transfer mispricing increases with a firm's R&D intensity. Third, tax-motivated transfer mispricing is concentrated in countries that are not tax havens and have low-to-medium-level corporate tax rates.
A 5-day cytoreductive chemotherapy followed by haplo-identical hsct (FA5-BUCY) as a tumor-ablative regimen improved the survival of patients with advanced hematological malignancies

Haplo-HSCT has been used when HLA-matched siblings are not available. Conditioning regimens aim to reduce tumor burden prior to HSCT and provide sufficient immunoablation. We report the outcome of haplo-HSCT in 63 consecutive patients from 2/2013 to 12/2015 (19 females/44 males) with high-risk or relapsed/refractory hematological malignancies (n=29-AML; 8-sAML; 19-ALL; 5-advanced-MDS; 2-CML-BC). Median age was 20 years (range: 1.1-49). Twenty-one patients achieved remission prior to transplant, while 42 did not. Patients received FA5-BUCY, i.e., 5-day salvage chemotherapy (Fludarabine/Ara-C) and conditioning (Busulfan/Cyclophosphamide). GvHD prophylaxis included ATG, CsA, MMF and short-term MTX. All patients received stem cells from bone marrow and peripheral blood, and achieved successful engraftment, except two who died before. With a median follow-up of 269 days (120-1081), 42/63 patients are still alive and disease-free. Two-year OS and RFS were similar in patients not in remission and in those in complete remission (61.3% vs 56.3%, p=0.88; 58.3% vs 56.3%, p=0.991). Non-relapse mortality and relapse incidence were 22.2% and 11.1%, respectively. Severe acute-GvHD occurred in 4/63 patients. Transplant-related mortality was low at day+100 (17.5%) and for the entire study period (20.6%). Unexpectedly, few patients experienced mild-to-moderate toxicity, and main causes of death were infection and GvHD. BM blast counts, age, and donor-recipient gender-pairs did not affect the outcome. Less chemotherapy cycles prior to HSCT might result in more favorable outcome. Thus, haplo-HSCT with FA5-BUCY appears promising for advanced disease, especially when TBI and amsacrine, used for FLAMSA, are not available and in pediatric patients for whom TBI is not recommended.
Transversal Shear Effect in Moderately Thick Shells from Materials with Characteristics Dependent on the Kind of Stress State under Creep-Damage Conditions: Theoretical Framework

The refined theory of creep deformation and creep damage in moderately thick shells of revolution which accounts for transversal shears and additionally for nonlinear distribution across its thickness of the components of the strain tensor as well as of the angles of rotation of the triad of vectors defined the position of the arbitrary point of a shell is discussed. A constitutive model for describing the creep deformation and directional nature of damage under creep conditions in initially isotropic materials with characteristics dependent on the kind of the stress state has been used. The governing equations of the moderately thick shell theory under discussion are introduced, and the initial/boundary-value problem in the frame of the physical nonlinearity and geometrical linearity has been formulated. The numerical tool developed for analysis of creep deformation and creep damage in moderately thick shells of revolution using the proposed theory is discussed.
Computational Thermodynamics of CoNiGa High Temperature Shape Memory Alloys

Computational Thermodynamics of CoNiGa High Temperature Shape Memory Alloys. (August 2011) Arpita Ramesh Chari, B.E. , M.S.Ramaiah Institute of Technology Chair of Advisory Committee: Dr. Raymundo Arroyave Shape Memory Alloys (SMAs) are advanced materials with interesting properties such as pseudoelasticity (PE) and the shape memory effect (SME). Recently, the CoNiGa system has emerged as the basis for very promising High Temperature Shape Memory Alloys (HTSMAs),with possible applications in the aerospace and automotive industries. Although the CoNiGa system shows significant promise for it’s use as HTSMAs, limited studies are available on them. Hence, a more intensive investigation of these alloys is necessary to understand their phase stability over a wide range of temperature and compositions in order for further development of CoNiGabased HTSMAs and future use of the model in alloy design. This formed the basis of motivation for the present work. In this work, a thermodynamic model of the ternary system is calculated based on the CALPHAD approach, to investigate the thermodynamic properties, phase stability and shape memory properties of these alloys. The CALPHAD approach is a computational method that enables the calculations of thermodynamic properties of systems. This method uses all available experimental and theoretical data in order to calculate the Gibbs energies of the phases in the system. The software used to carry out the calculations is ”ThermoCalc”, which is a computational software using CALPHAD principles, based on the minimization of Gibbs energy, and is enhanced by a global minimization technique on the system. The stability of the β phase at high temperatures was enforced accurately by remodeling the CoGa system. The binary
15 q 11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders

Human chromosome 15q11-13 is a complex locus containing imprinted genes as well as a cluster of three GABAA receptor subunit (GABR) genes—GABRB3, GABRA5 and GABRG3. Deletion or duplication of 15q11-13 GABR genes occurs in multiple human neurodevelopmental disorders including Prader-Willi syndrome (PWS), Angelman syndrome (AS) and autism. GABRB3 protein expression is also reduced in Rett syndrome (RTT), caused by mutations in MECP2 on Xq28. Although Gabrb3 is biallelically expressed in mouse brain, conflicting data exist regarding the imprinting status of the 15q11-13 GABR genes in humans. Using coding single nucleotide polymorphisms we show that all three GABR genes are biallelically expressed in 21 control brain samples, demonstrating that these genes are not imprinted in normal human cortex. Interestingly, four of eight autism and one of five RTT brain samples showed monoallelic or highly skewed allelic expression of one or more GABR gene, suggesting that epigenetic dysregulation of these genes is common to both disorders. Quantitative real-time RT–PCR analysis of PWS and AS samples with paternal and maternal 15q11-13 deletions revealed a paternal expression bias of GABRB3, while RTT brain samples showed a significant reduction in GABRB3 and UBE3A. Chromatin immunoprecipitation and bisulfite sequencing in SH-SY5Y neuroblastoma cells demonstrated that MeCP2 binds to methylated CpG sites within GABRB3. Our previous studies demonstrated that homologous 15q11-13 pairing in neurons was dependent on MeCP2 and was disrupted in RTT and autism cortex. Combined, these results suggest that MeCP2 acts as a chromatin organizer for optimal expression of both alleles of GABRB3 in neurons.
Repeated bouts of exercise in patients with anterior cruciate ligament reconstruction.

PURPOSE Reduced quadriceps activation after anterior cruciate ligament reconstructions (ACL-R) has been reported. Patients often return to daily exercise or sport after ACL-R; however, there is little information regarding quadriceps function after exercise in this population. Therefore, the purpose of this study was to compare quadriceps strength and central activation after repeated bouts of exercise between individuals with and without a history of ACL-R. METHODS Eighteen recreationally active subjects participated in this study: 8 with unilateral ACL-R at least 6 months earlier and 10 healthy controls. All subjects performed 30 min of continuous exercise on two consecutive days. Exercise included repeated bouts of inclined treadmill walking and jumping exercises. We measured maximal isometric knee extension torque and quadriceps central activation ratio (CAR) using the superimposed burst technique before and after exercise on day 1. Subjects returned 24 h later (day 2) for a repeat testing session. RESULTS There was a significant group-time interaction for knee extension torque. ACL-R subjects were weaker at baseline on day 1 of testing (P = 0.01) but exhibited no significant reduction in knee extension torque after exercise (P = 0.13), whereas the healthy control subjects did (P = 0.01). Knee extension torque on day 2 remained significantly lower than baseline for the controls (P = 0.03), but not the ACL-R (P = 0.73). On day 2, both groups experienced significantly reduced knee extension torque after exercise. There was no group-time interaction for CAR, but a group main effect indicated that, on average, ACL-R had significantly lower CAR bilaterally compared with healthy controls. CONCLUSIONS The quadriceps in ACL-R knees were weaker and showed less reduction of isometric knee extension torque compared with healthy group in day 1. However, there were no group differences of quadriceps strength on day 2.
Detection of driver and subclonal mutations in myelofibrosis: clinical impact on pharmacologic and transplant based treatment strategies

ABSTRACT Introduction: Myelofibrosis (MF) is the most aggressive form among Philadelphia negative (Ph–) myeloproliferative neoplasms (MPNs). In the last years, the mutational landscape of MF has expanded remarkably by the identification of additional recurrent mutations, called subclonal mutations. Areas covered: Here we describe the available data about the currently identified subclonal mutations and their prognostic value in MF patients. We also review the practical value of including such molecular information in available prognostic models for both outcome prediction and possibly treatment decision with regards to transplant indication. Lastly, we covered the available data on the application of molecular markers for minimal residual disease (MRD) monitoring after transplantation. Expert commentary: The demonstration of the prognostic value of additional mutations suggests to define this molecular profile at diagnosis and when an allogeneic transplant can be advised, particularly in younger patients. The presence of molecular markers might offer the possibility to evaluate the depth of remission and to monitor MRD after transplantation. Prospective clinical studies are needed to validate the use of this molecular data in the routine clinical practice.
Characterization of anti‐inflammatory effect and possible mechanism of action of Tibouchina granulosa

Tibouchina granulosa, popularly known as ‘quaresmeira’, belong to a genus widely used in the traditional medicine as infusions from their leaves. Other species of Tibouchina are used as antibacterial, antioxidant or antileishmanial. In this work, our objectives were to investigate the biological effects of T. granulosa in models of acute inflammation.
Effectiveness of Protected Areas in Maintaining Plant Production

Given the central importance of protected area systems in local, regional and global conservation strategies, it is vital that there is a good understanding of their effectiveness in maintaining ecological functioning. Here, we provide, to our knowledge, the first such global analysis, focusing on plant production, a “supporting” ecosystem function necessary for multiple other ecosystem services. We use data on the normalized difference vegetation index (NDVI) as a measure of variation in plant production in the core, boundary and surroundings of more than 1000 large protected areas over a 25 year period. Forested protected areas were higher (or similar), and those non-forested were lower (or similar), in NDVI than their surrounding areas, and these differences have been sustained. The differences from surrounding areas have increased for evergreen broadleaf forests and barren grounds, decreased for grasslands, and remained similar for deciduous forests, woodlands, and shrublands, reflecting different pressures on those surroundings. These results are consistent with protected areas being effective both in the representation and maintenance of plant production. However, widespread overall increases in NDVI during the study period suggest that plant production within the core of non-forested protected areas has become higher than it was in the surroundings of those areas in 1982, highlighting that whilst the distinctiveness of protected areas from their surroundings has persisted the nature of that difference has changed.
Angular Power Distribution of Wireless Channel in Mine Tunnels

The statistical characteristics of the angular power distribution of the wireless channel in mine tunnels are the concern of this paper. Firstly, we develop a ray-based channel model which provides the angular power spectrum (APS) in tunnels. We discuss the allowed rays existing in a tunnel based on the modal theory. The number of the allowed rays is limited. The directions of the rays are discrete. They are influenced by the excitation conditions. And then we deduce the propagation parameters as the functions of the direction of arrival (DOA) for each ray to reduce the computational burden. The model is validated by experimental measurements. Then theoretical results deduced from our model show that APS in the tunnel follows Gaussian distribution. For vertical polarization, the spread of the azimuth angle is more sensitive to the excitation conditions. While for horizontal polarization, the spread of the elevation angle is more sensitive. DOI: http://dx.doi. org/10.11591/telkomnika.v11i3. 2224
A domain-specific language for the hybridization and static condensation of finite element methods

In this paper, we introduce a domain-specific language (DSL) for concisely expressing localized linear algebra on finite element tensors, and its integration within a code-generation framework. This DSL is general enough to facilitate the automatic generation of cell-local linear algebra kernels necessary for the implementation of static condensation methods and local solvers for a variety of problems. We demonstrate its use for the static condensation of continuous Galerkin problems, and systems arising from hybridizing a finite element discretization. Additionally, we demonstrate how this DSL can be used to implement local post-processing techniques to achieve superconvergent approximation to mixed problems. Finally, we show that these hybridization and static condensation procedures can act as effective preconditioners for mixed problems. We use the DSL in this paper to implement high-level preconditioning interfaces for the hybridization of mixed problems, as well generic static condensation. Our implementation builds on the solver composability of the PETSc library by providing reduced operators, which are obtained from locally assembled expressions, with the necessary context to specify full solver configurations on the resulting linear systems. We present some examples for model second-order elliptic problems, including a new hybridization preconditioner for the linearized system in a nonlinear method for a simplified atmospheric model.
Shifts in the European Discourses on Migration and Development

The issue of migration and development is currently high on the agenda of both development agencies and research institutes in several European countries. It used to be discussed during the 1960/1970s within a framework which, among others, comprised push-and pull factors in migration, brain drain, remittances and return migration. Its return on the development agenda occurs within the context of European post-modern societies, globalization and transnationalism. Key notions now are remittances and foreign direct investment, knowledge transfer, brain gain, transnational entrepreneurship and diasporas. This paper aims to explain the shifts in paradigms and discourses, with reference to the European Union, and particularly in the Netherlands and Germany. Research efforts and policy documents were scrutinized to trace the shifts in discourses. Moreover, the role of different actors in the debate -government agencies, migrant organizations, development funding agencies, and research institutes — is explored. Although some comparisons were made with similar situations in other parts of the world, the paper focuses on Asia-Europe migration. Although the migration and development debate has acquired a more positive tone, the recognition of the potential of diasporas for development varies by country context and policies have yet to integrate migration and development issues in their frameworks.
Antagonistic Regulation of ABA and GA in Metabolism and Signaling Pathways

The phytohormones gibberellic acid (GA) and abscisic acid (ABA) are widely recognized as essential endogenous regulators that mostly play antagonistic roles in plant developmental processes and environmental responses. A variety of both internal and external cues oppositely regulate GA and ABA biosynthesis and catabolism, which directly and indirectly affect their signaling pathways and subsequent responses. Recent discoveries have revealed direct molecular links between GA- and ABA-signaling components, which provide novel insights into their antagonistic regulation. In this review, we mainly focus on these recent reports and the growing understanding of GA and ABA antagonism in metabolic regulation and signaling interactions, and attempt to clarify the problems and challenges involved in exploring the complicated regulatory events associated with these two phytohormones.
Does the presence of sentinel lymph node macrometastases in breast cancer patients require axillary lymph node dissection?—Single‐center analysis

According to the current guidelines on treatment of breast cancer patients, identification of metastases in the sentinel lymph node (SLN (+)) is not an absolute indication for necessary axillary lymph node dissection (ALND). In our study, we present long‐term outcomes of treatment among SLN(+) patients referred for conservative treatment, for example, no further ALND. A total of 3145 breast cancer patients subjected to sentinel lymph node biopsy (SLNB) between November 2008 and June 2015. SLN metastases were identified in 719 patients (22.9%). Locoregional recurrences and distant metastases as endpoints were distinquished. The mean follow‐up time for patients after ALND was 36.2 months (6‐74 months); 18.8 months (6‐38 months) for patients with SLN macrometastases without ALND; and 34.0 months (6‐74 months) for patients with micrometastases. Adjuvant ALND was performed in 626 of SLN(+) patients. Conservative treatment was applied in the remaining 93 cases. Among SLN(+) patients without adjuvant ALND, there was one case of recurrence (1.07%). In the group of patients without SLN, metastases recurrence was noted in 32 patients (1.32%). Among SLN(+) patients diagnosed with macrometastases, recurrence concerned 2.01% of analyzed cases (all subjected to ALND). Lack of radical surgical treatment in SLN(+) breast cancer patients did not lead to worsening long‐term outcomes. In the occurrence of macrometastases to the sentinel lymph node, abandoning completion axillary lymph node dissection might be a reasonable option. However, it would require continuation of current research, preferably involving a clinical trial.
Towards Directly Modeling Raw Speech Signal for Speaker Verification Using CNNS

Speaker verification systems traditionally extract and model cepstral features or filter bank energies from the speech signal. In this paper, inspired by the success of neural network-based approaches to model directly raw speech signal for applications such as speech recognition, emotion recognition and anti-spoofing, we propose a speaker verification approach where speaker discriminative information is directly learned from the speech signal by: (a) first training a CNN-based speaker identification system that takes as input raw speech signal and learns to classify on speakers (unknown to the speaker verification system); and then (b) building a speaker detector for each speaker in the speaker verification system by replacing the output layer of the speaker identification system by two outputs (genuine, impostor), and adapting the system in a discriminative manner with enrollment speech of the speaker and impostor speech data. Our investigations on the Voxforge database shows that this approach can yield systems competitive to state-of-the-art systems. An analysis of the filters in the first convolution layer shows that the filters give emphasis to information in low frequency regions (below 1000 Hz) and implicitly learn to model fundamental frequency information in the speech signal for speaker discrimination.
INFINITARY COMBINATORY REDUCTION SYSTEMS : NORMALISING REDUCTION

We study normalising reduction strategies for infinitary Combinatory Reduction Systems (iCRSs). We prove that all fair, outermost-fair, and needed-fair strategies are normalising for orthogonal, fully-extended iCRSs. These facts properly generalise a number of results on normalising strategies in first-order infinitary rewriting and provide the first examples of normalising strategies for infinitary λ-calculus.