Miracle-dz/UniFAR-FTUs huggingface dataset:
Bilateral cortical representation of the trunk midline in human first somatic sensory area

The cortical representation of the trunk zone in the human first somatosensory area was studied with functional magnetic resonance imaging (fMRI) to establish whether the cutaneous regions close to the midline are represented in this area of both hemispheres. Cortical activation foci evoked by unilateral tactile stimulation of ventral trunk regions were detected in the postcentral gyrus of the contralateral hemisphere slightly medial to or just behind the omega‐shaped region of the central sulcus and in the anterior bank of the postcentral sulcus. These regions probably correspond to the trunk ventral midline representation zones of areas 3a–3b and 1–2, respectively. Stimulation of cutaneous regions adjacent to the midline evoked activation foci also in the ipsilateral postcentral gyrus in regions symmetrical to those activated in the contralateral hemisphere. These data demonstrate that in humans, as in nonhuman primates, the cutaneous regions adjacent to the trunk midline are represented bilaterally in the first somatic sensory cortex. Whether the ipsilateral activation depends on callosal or extracallosal inputs remains to be elucidated. Hum Brain Mapping, 2005. © 2005 Wiley‐Liss, Inc.
Risk Assessment of Aluminum in Drinking Water between Two Residential Areas

A cross-sectional study was conducted at Sungai Lembing (SL) and Bukit Ubi (BU), Kuantan, Malaysia. The main objectives of this epidemiological study were to determine the aluminum concentration in drinking water, to compare with the government standard and to perform health risk assessment prediction among respondents from these two residential areas. A total of 100 respondents were selected from the study areas based on a few inclusive and exclusive criteria. Two duplicates of treated water samples were taken from each respondent's house using a 200 mL high-density polyethylene (HDPE) bottle and 0.4 mL (69%) pure concentrated nitric acid added as preservative. Aluminum concentrations were analyzed using Lambda 25 UV/V spectrophotometer. The result showed that the mean concentration of aluminum in drinking water from SL was 0.11 ± 0.0634 mg/L and 0.12 ± 0.0462 mg/L for BU. The mean value of Chronic Daily Intake (CDI) in SL (0.0035 ± 0.0028 mg/kg/day) was lower compared to BU (0.0037 ± 0.0021 mg/kg/day). The Hazard Index (HI) calculation showed all respondents had HI less than 1. In conclusion, there was unlikely potential for adverse health effects from aluminum intake in drinking water. However, it was necessary for some action to be taken in order to reduce aluminum levels found in drinking water in both locations.
Phytochemical, antimicrobial, and antioxidant activities of different citrus juice concentrates

Abstract The search for new antimicrobial compounds is ongoing. Its importance cannot be overemphasized in an era of emerging resistant pathogenic organisms. This study therefore investigated the phytochemical composition and antioxidant and antimicrobial activities of different citrus juice concentrates. Fruit juices of Citrus tangerine (tangerine), Citrus paradisi (grape), Citrus limon (lemon), and Citrus aurantifolia (lime) were evaluated. Antimicrobial activities against five bacterial and three fungal strains were evaluated. The results revealed the presence of alkaloids, flavonoids, steroids, terpenoids, saponins, cardiac glycosides, and reducing sugars in all the juice concentrates. DPPH (1,1‐diphenyl‐2‐picrylhydrazyl) radical scavenging capacities varied with tangerine and grape juices having better scavenging capacities than lemon and lime juices. Grape juice was observed to have a significantly higher (P < 0.05) ferric‐reducing antioxidant potential (FRAP) value (364.2 ± 10.25 μmol/L Fe(II)/g of the extract) than the reference antioxidant, ascorbic acid (312.88 ± 5.61 μmol/L). Antimicrobial studies revealed differential antimicrobial activities against different microbial strains. Zones of inhibition ranging from 4 to 26 mm were observed for the antibacterial tests with 0–24 mm for antifungal test. Minimum inhibitory concentrations (MIC) and minimum bacteriostatic concentrations (MBC) for concentrates against bacterial strains ranged from 12.5 to 200 μg/mL. Lemon and lime juice concentrates had lower MIC and MBC values with orange and tangerine having the highest values. Minimum fungicidal concentrations ranged from 50 to 200 μg/mL. The results of this study suggest that these juice concentrates may have beneficial antimicrobial roles that can be exploited in controlling unwanted microbial growth.
Incident Heart Failure Prediction in the Elderly: The Health ABC Heart Failure Score

Background—Despite the rising heart failure (HF) incidence and aging United States population, there are no validated prediction models for incident HF in the elderly. We sought to develop a new prediction model for 5-year risk of incident HF among older persons. Methods and Results—Proportional hazards models were used to assess independent predictors of incident HF, defined as hospitalization for new-onset HF, in 2935 elderly participants without baseline HF enrolled in the Health ABC study (age, 73.6±2.9 years, 47.9% males, 58.6% whites). A prediction equation was developed and internally validated by bootstrapping, allowing the development of a 5-year risk score. Incident HF developed in 258 (8.8%) participants during 6.5±1.8 years of follow-up. Independent predictors of incident HF included age, history of coronary disease and smoking, baseline systolic blood pressure and heart rate, serum glucose, creatinine, and albumin levels, and left ventricular hypertrophy. The Health ABC HF model had a c-statistic of 0.73 in the derivation dataset, 0.72 by internal validation (optimism-corrected), and good calibration (goodness-of-fit &khgr;2 6.24, P=0.621). A simple point score was created to predict incident HF risk into 4 risk groups corresponding to <5%, 5% to 10%, 10% to 20%, and >20% 5-year risk. The actual 5-year incident HF rates in these groups were 2.9%, 5.7%, 13.3%, and 36.8%, respectively. Conclusion—The Health ABC HF prediction model uses common clinical variables to predict incident HF risk in the elderly, an approach that may be used to target and treat high-risk individuals.
Assessment of the temporal trend of the exposure of people to electromagnetic fields produced by base stations for mobile telephones.

Monitoring of electric field levels produced by base stations (BSs) for mobile telephones of different typologies (TACS. GSM, DCS) has been carried out. Results show that BSs can be classified as 'business' or 'residential'. The mean value of six minutes averaged E-field value measured between 10 a.m. and 1 p.m. corresponds to the 84% of the maximum daily six minutes averaged value. Comparison between electromagnetic field levels produced by BSs and their phone traffic data, supplied by companies, is shown. Finally, on an hourly average basis, a daily curve has been constructed of the exposure trend produced by such installations.
Inclinations and Black Hole Masses of Seyfert 1 Galaxies

A tight correlation between black hole mass (MBH) and central velocity dispersion (σ) has been found recently for both active and quiescent galaxies. By applying this correlation, we develop a simple method to derive the inclination angles for a sample of 11 Seyfert 1 galaxies that have both measured central velocity dispersions and black hole masses estimated by reverberation mapping. These angles, with a mean value of 36° that agrees well with the result obtained by fitting the iron Kα lines of Seyfert 1 galaxies observed with ASCA, provide further support to the orientation-dependent unification scheme of active galactic nuclei (AGNs). A positive correlation of the inclinations with observed FWHMs of the Hβ line and a possible anticorrelation with the nuclear radio loudness have been found. We conclude that more accurate knowledge of inclinations and broad-line region dynamics is needed to improve the black hole mass determination of AGNs with the reverberation mapping technique.
Mineral Deficiency and Organic Constituents in Tobacco Plants. II. Amino Acids.

In a preceding paper (7) changes in several organic constituents (including alkaloids, sugars, and organic acids) in tobacco plants due to a mineral deficiency were reported. This paper is a continued discussion on this fundamental problem in plant physiology and deals with another important group of organic constituents, amino acids. Amino acids have long been suspected of being related to alkaloid formation. Tryptophan, lysine, ornithine, proline, leucine, and many others were investigated as possible precursors of tobacco alkaloids (5). Recent reports (1, 3) indicated the possible role of glutamine and glutamic acid in alkaloid formation. Results are presented here on relative changes of amino acids in tobacco plants due to the deficiency of one of the following elements: N,P,K,Ca.Mg. S, and B. Special attention is paid to the possible relation among amino acids and alkaloids which were reported in a previous paper (7).
Life-History Evolution When Lestes Damselflies Invaded Vernal Ponds

Abstract We know little about the macroevolution of life-history traits along environmental gradients, especially with regard to the directionality compared to the ancestral states and the associated costs to other functions. Here we examine how age and size at maturity evolved when Lestes damselflies shifted from their ancestral temporary pond habitat (i.e., ponds that may dry once every decade or so) to extremely ephemeral vernal ponds (ponds that routinely dry completely each year). Larvae of three species were reared from eggs until emergence under different levels of photoperiod and transient starvation stress. Compared to the two temporary-pond Lestes, the phylogenetically derived vernal-pond Lestes dryas developed more rapidly across photoperiod treatments until the final instar, and only expressed plasticity in development time in the final instar under photoperiod levels that simulated a later hatching date. The documented change in development rate can be considered adaptive and underlies the success of the derived species in vernal ponds. Results suggest associated costs of faster development are lower mass at maturity and lower immune function after transient starvation stress. These costs may not only have impeded further evolution of the routine development rate to what is physiologically maximal, but also maintained some degree of plasticity to time constraints when the habitat shift occurred.
On the aggregate effects of immigration in Spain

Over the period 1995–2006 the Spanish economy experienced a rapid increase in employment and output growth, a surge in investment over GDP, a substantial deterioration in the current account balance and an improvement in the finances of the social security system. This paper presents a dynamic general equilibriummodel designed to quantify the role played by immigration in shaping these facts. In the context of the aging of the Spanish population, we also analyze the medium and long run effects of the immigration process accounting for relevant supply and demand effects. This is done by allowing for enough heterogeneity in the demographic characteristics of immigrant and native workers in a way that allow us to perform counterfactual experiments regarding the flow of immigrants and its skill composition.
Microbank: Architecting Through-Silicon Interposer-Based Main Memory Systems

Through-Silicon Interposer (TSI) has recently been proposed to provide high memory bandwidth and improve energy efficiency of the main memory system. However, the impact of TSI on main memory system architecture has not been well explored. While TSI improves the I/O energy efficiency, we show that it results in an unbalanced memory system design in terms of energy efficiency as the core DRAM dominates overall energy consumption. To balance and enhance the energy efficiency of a TSI-based memory system, we propose μbank, a novel DRAM device organization in which each bank is partitioned into multiple smaller banks (or μbanks) that operate independently like conventional banks with minimal area overhead. The μbank organization significantly increases the amount of bank-level parallelism to improve the performance and energy efficiency of the TSI-based memory system. The massive number of μbanks reduces bank conflicts, hence simplifying the memory system design. We evaluated a sophisticated prediction-based DRAM page-management policy, which can improve performance by up to 20.5% in a conventional memory system without μbanks. However, a μbank-based design does not require such a complex page-management policy and a simple open-page policy is often sufficient -- achieving within 5% of a perfect predictor. Our proposed μbank-based memory system improves the IPC and system energy-delay product by 1.62× and 4.80×, respectively, for memory-intensive SPEC 2006 benchmarks on average, over the baseline DDR3-based memory system.
Optimizing Semi-Analytical Algorithms for Estimating Chlorophyll-a and Phycocyanin Concentrations in Inland Waters in Korea

Several semi-analytical algorithms have been developed to estimate the chlorophyll-a (Chl-a) and phycocyanin (PC) concentrations in inland waters. This study aimed at identifying the influence of algorithm parameters on the output variables and searching optimal parameter values. The optimal parameters of seven semi-analytical algorithms were applied to estimate the Chl-a and PC concentrations. The absorption coefficient measurements were coupled with pigment measurements to calibrate the algorithm parameters. For sensitivity analysis, the elementary effect test was conducted to analyze the influence of the algorithm parameters. The sensitivity analysis results showed that the parameters in the Y function and specific absorption coefficient were the most sensitive parameters. Then, the parameters were optimized via a single-objective optimization that involved one objective function being minimized and a multi-objective optimization that contained more than one objective function. The single-objective optimization led to substantial errors in absorption coefficients. In contrast, the multi-objective optimization improved the algorithm performance with respect to both the absorption coefficient estimates and pigment concentration estimates. The optimized parameters of the absorption coefficient reflected the high-particulate content in waters of the Baekje reservoir using an infrared backscattering wavelength and relatively high value of Y. Moreover, the results indicate the value of measuring the site-specific absorption if site-specific optimization of semi-analyical algorithm parameters was envisioned.
Mitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI

Mitochondrial Ca2+ uptake, central to neural metabolism and function, is diminished in aging whereas enhanced after acute/sub-acute traumatic brain injury. To develop relevant translational models for these neuropathologies, we determined the impact of perturbed mitochondrial Ca2+ uptake capacities on intrinsic brain activity using clinically relevant markers. From a multi-compartment estimate of probable baseline Ca2+ ranges in the brain, we hypothesized that reduced or enhanced mitochondrial Ca2+ uptake capacity would decrease or increase spontaneous neuronal activity respectively. As resting state fMRI-BOLD fluctuations and stimulus-evoked BOLD responses have similar physiological origins [1] and stimulus-evoked neuronal and hemodynamic responses are modulated by mitochondrial Ca2+ uptake capacity [2], [3] respectively, we tested our hypothesis by measuring hemodynamic fluctuations and spontaneous neuronal activities during normal and altered mitochondrial functional states. Mitochondrial Ca2+ uptake capacity was perturbed by pharmacologically inhibiting or enhancing the mitochondrial Ca2+ uniporter (mCU) activity. Neuronal electrical activity and cerebral blood flow (CBF) fluctuations were measured simultaneously and integrated with fMRI-BOLD fluctuations at 11.7T. mCU inhibition reduced spontaneous neuronal activity and the resting state functional connectivity (RSFC), whereas mCU enhancement increased spontaneous neuronal activity but reduced RSFC. We conclude that increased or decreased mitochondrial Ca2+ uptake capacities lead to diminished resting state modes of brain functional connectivity.
Cardiomyocyte oxidants production may signal to T. cruzi intracellular development

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, presents a variable clinical course, varying from asymptomatic to serious debilitating pathologies with cardiac, digestive or cardio-digestive impairment. Previous studies using two clonal T. cruzi populations, Col1.7G2 (T. cruzi I) and JG (T. cruzi II) demonstrated that there was a differential tissue distribution of these parasites during infection in BALB/c mice, with predominance of JG in the heart. To date little is known about the mechanisms that determine this tissue selection. Upon infection, host cells respond producing several factors, such as reactive oxygen species (ROS), cytokines, among others. Herein and in agreement with previous data from the literature we show that JG presents a higher intracellular multiplication rate when compared to Col1.7G2. We also showed that upon infection cardiomyocytes in culture may increase the production of oxidative species and its levels are higher in cultures infected with JG, which expresses lower levels of antioxidant enzymes. Interestingly, inhibition of oxidative stress severely interferes with the intracellular multiplication rate of JG. Additionally, upon H2O2-treatment increase in intracellular Ca2+ and oxidants were observed only in JG epimastigotes. Data presented herein suggests that JG and Col1.7G2 may sense extracellular oxidants in a distinct manner, which would then interfere differently with their intracellular development in cardiomyocytes.
Threat of Death and Autobiographical Memory

We investigated autobiographical memory in a group of passengers onboard a transatlantic flight that nearly ditched at sea. The consistency of traumatic exposure across passengers, some of whom developed posttraumatic stress disorder (PTSD), provided a unique opportunity to assess verified memory for life-threatening trauma. Using the Autobiographical Interview, which separates episodic from nonepisodic details, passengers and healthy controls (HCs) recalled three events: the airline disaster (or a highly negative event for HCs), the September 11, 2001, attacks, and a nonemotional event. All passengers showed robust mnemonic enhancement for episodic details of the airline disaster. Although neither richness nor accuracy of traumatic recollection was related to PTSD, production of nonepisodic details for traumatic and nontraumatic events was elevated in PTSD passengers. These findings indicate a robust mnemonic enhancement for trauma that is not specific to PTSD. Rather, PTSD is associated with altered cognitive control operations that affect autobiographical memory in general.
Quantitative single-cell characterization of bacterial interactions reveals type VI secretion is a double-edged sword

Interbacterial interaction pathways play an important role in defining the structure and complexity of bacterial associations. A quantitative description of such pathways offers promise for understanding the forces that contribute to community composition. We developed time-lapse fluorescence microscopy methods for quantitation of interbacterial interactions and applied these to the characterization of type VI secretion (T6S) in Pseudomonas aeruginosa. Our analyses allowed a direct determination of the efficiency of recipient cell lysis catalyzed by this intercellular toxin delivery pathway and provided evidence that its arsenal extends beyond known effector proteins. Measurement of T6S apparatus localization revealed correlated activation among neighboring cells, which, taken together with genetic data, implicate the elaboration of a functional T6S apparatus with a marked increase in susceptibility to intoxication. This possibility was supported by the identification of T6S-inactivating mutations in a genome-wide screen for resistance to T6S-mediated intoxication and by time-lapse fluorescence microscopy analyses showing a decreased lysis rate of recipient cells lacking T6S function. Our discoveries highlight the utility of single-cell approaches for measuring interbacterial phenomena and provide a foundation for studying the contribution of a widespread bacterial interaction pathway to community structure.
Effectiveness of Microporous Polysaccharide Hemospheres for Achieving Hemostasis in Mohs Micrographic Surgery

BACKGROUND Microporous polysaccharide hemospheres consist of controlled-porosity spherical particles manufactured from bioinert plant polysaccharide. Microporous polysaccharide hemospheres facilitate hemostasis by rapidly absorbing the fluid component of blood, concentrating platelets and clotting factors to accelerate blood clotting. OBJECTIVE The objective was to compare a microporous polysaccharide hemosphere bandage and electrocautery in achieving hemostasis. METHODS Twenty-four patients with a total of 48 stages of Mohs micrographic surgery were included. Patients were stratified by whether or not they were taking anticoagulant medications. Within each group, patients were randomized to receive either the microporous polysaccharide hemosphere bandage or electrocautery. Outcomes included bleeding through the dressing (early time point) and active bleeding upon dressing removal (late time point). RESULTS Nineteen patients not taking anticoagulants had 40 stages, of which 18 received the study bandage and 22 received electrocautery. The remaining 5 patients on anticoagulants had 8 stages, of which 4 received the study bandage and 4 received electrocautery. In both total and subgroup analysis, there was a higher incidence of bleeding through the dressing with the study bandage (p<0.05), but no increase in the incidence of active bleeding upon dressing removal (p>0.05). CONCLUSION The microporous polysaccharide hemosphere study bandage had an increased incidence of bleeding through the dressing compared to electrocautery, but did not have an increased incidence of active bleeding upon dressing removal.
A Simple Approach to Author Profiling in MapReduce

Author profiling, being an important problem in forensics, security, marketing, and literary research, needs to be accurate. With massive amounts of online text readily available on which we might need to perform author profiling, building a fast system is as important as building an accurate system, but this can be challenging. However, the use of distributive computing techniques like MapReduce can significantly lower processing time by distributing tasks across multiple machines. Our system uses MapReduce programming paradigm for most parts of the training process, which makes our system fast. Our system uses word n-grams including stopwords, punctuations and emoticons as features and TF-IDF (term frequency inverse document frequency) as the weighing scheme. These are fed to the logistic regression classifier that predicts the age and gender of the authors. We were able to obtain a competitive accuracy in most categories and even obtained winning accuracies for two of the categories each in both test corpus 1 and test corpus 2.