Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychosocial adjustment in children and adolescents with a parent with multiple sclerosis: a systematic review

Objective: This systematic review explored the potential impact of parental multiple sclerosis on their offspring. It considered adjustment to parental multiple sclerosis at different developmental stages and the factors associated with good versus poor adjustment. Data sources: MEDLINE, EMBASE, PsycINFO, CINAHL and Web of Science were searched for studies on children with a parent with multiple sclerosis. Inclusion and exclusion criteria were formulated. Hand-searching journals and reference lists, contacting authors and multiple sclerosis societies for additional unpublished papers complemented the searches. Review methods: Twenty studies that satisfied the inclusion criteria were included. The research articles were ranked according to a quality assessment checklist and were categorized as good, medium or poor quality. Results: The review found good evidence to suggest that parental multiple sclerosis has a negative impact on children’s social and family relationships and their psychological well-being. The review also identified potential factors associated with poor adjustment. These factors included parental negative emotions, increased illness severity, family dysfunction, children’s lack of knowledge about the illness and lack of social support. Adolescent children also seemed to be more at risk for psychosocial problems than school-age children. Conclusions: There is good evidence that parental multiple sclerosis has a negative psychosocial impact on children, especially on adolescents.
An empirical analysis of machine learning models for automated essay grading

9 Background. Automated Essay Scoring (AES) is an area which falls at the intersection of computing and linguistics. AES systems conduct a linguistic analysis of a given essay or prose and then estimates the writing skill or the essay quality in the form a numeric score or a letter grade. AES systems are useful for the school, university and testing company community for efficiently and effectively scaling the task of grading a large number of essays. 10
Characterization, Localization, Essentiality, and High-Resolution Crystal Structure of Glucosamine 6-Phosphate N-Acetyltransferase from Trypanosoma brucei

ABSTRACT A gene predicted to encode Trypanosoma brucei glucosamine 6-phosphate N-acetyltransferase (TbGNA1; EC 2.3.1.4) was cloned and expressed in Escherichia coli. The recombinant protein was enzymatically active, and its high-resolution crystal structure was obtained at 1.86 Å. Endogenous TbGNA1 protein was localized to the peroxisome-like microbody, the glycosome. A bloodstream-form T. brucei GNA1 conditional null mutant was constructed and shown to be unable to sustain growth in vitro under nonpermissive conditions, demonstrating that there are no metabolic or nutritional routes to UDP-GlcNAc other than via GlcNAc-6-phosphate. Analysis of the protein glycosylation phenotype of the TbGNA1 mutant under nonpermissive conditions revealed that poly-N-acetyllactosamine structures were greatly reduced in the parasite and that the glycosylation profile of the principal parasite surface coat component, the variant surface glycoprotein (VSG), was modified. The significance of results and the potential of TbGNA1 as a novel drug target for African sleeping sickness are discussed.
Convergent Evolution Between Insect and Mammalian Audition

How to Hear In mammalian ears, a chain of biophysical events allows for the translation of airborne acoustic energy into mechanical vibrations that can be detected by mechanosensory cells in the cochlear. Mammalian ears have been considered largely unique in this transformation because it is the delicate, mammalian-specific, bones of the middle ear that facilitate this transmission, known as impedence conversion. In most other vertebrates the bones that make up the middle ear function as part of the lower jaw, limiting the potential for vertebrate convergence in this process. However, Montealegre-Z. et al. (p. 968, see the Perspective by Hoy) show that the rainforest katydid, an insect with ears on its hind legs, have converged on a similar three step impedence conversion process using a unique tympanum-lever organ. This convergence, across millions of years of evolutionary distance, shows the flexibility of morphology to adapt to biophysical challenges. In an example of convergent evolution, rainforest katydids hear using similar mechanisms to those found in mammalian ears. In mammals, hearing is dependent on three canonical processing stages: (i) an eardrum collecting sound, (ii) a middle ear impedance converter, and (iii) a cochlear frequency analyzer. Here, we show that some insects, such as rainforest katydids, possess equivalent biophysical mechanisms for auditory processing. Although katydid ears are among the smallest in all organisms, these ears perform the crucial stage of air-to-liquid impedance conversion and signal amplification, with the use of a distinct tympanal lever system. Further along the chain of hearing, spectral sound analysis is achieved through dispersive wave propagation across a fluid substrate, as in the mammalian cochlea. Thus, two phylogenetically remote organisms, katydids and mammals, have evolved a series of convergent solutions to common biophysical problems, despite their reliance on very different morphological substrates.
Mechanical efficiency of high versus moderate intensity aerobic exercise in coronary heart disease patients: A randomized clinical trial

Background Mechanical efficiency (ME) refers to the ability of an individual to transfer energy consumed by external work. A decreased ME, could represent an increased energy cost during exercise and may, therefore, be limited in terms of physical activity. This study aimed to compare the influence of two different exercise protocols: moderate continuous training (MCT) versus high intensity interval training (HIIT), as part of a cardiac rehabilitation program on ME values among coronary patients. Methods One hundred and ten coronary patients were assigned to either HIIT or MCT groups for 8 weeks. Incremental exercise tests in a cycle ergometer were performed to obtain VO2peak. Net energy expenditure (EE) and ME were obtained at intensities corresponding to the first (VT1) and second (VT2) ventilatory thresholds, and at VO2peak. Results Both exercise programs significantly increase VO2peak with a higher increase in the HIIT group (2.96 ± 2.33 mL/kg/min vs. 3.88 ± 2.40 mL/kg/min, for patients of the MCT and HIIT groups, respectively, p < 0.001). The ME at VO2peak and VT2 only significantly increased in the HIIT group. At VT1, ME significantly increased in both groups, with a greater increase in the HIIT group (2.20 ± 6.25% vs. 5.52 ± 5.53%, for patients of the MCT and HIIT groups, respectively, p < 0.001). Conclusions The application of HIIT to patients with chronic ischemic heart disease of low risk resulted in a greater improvement in VO2peak and in ME at VT1, than when MCT was applied. Moreover, only the application of HIIT brought about a significant increase in ME at VT2 and at VO2peak.
Differential expression patterns of housekeeping genes increase diagnostic and prognostic value in lung cancer

Background Using DNA microarrays, we previously identified 451 genes expressed in 19 different human tissues. Although ubiquitously expressed, the variable expression patterns of these “housekeeping genes” (HKGs) could separate one normal human tissue type from another. Current focus on identifying “specific disease markers” is problematic as single gene expression in a given sample represents the specific cellular states of the sample at the time of collection. In this study, we examine the diagnostic and prognostic potential of the variable expressions of HKGs in lung cancers. Methods Microarray and RNA-seq data for normal lungs, lung adenocarcinomas (AD), squamous cell carcinomas of the lung (SQCLC), and small cell carcinomas of the lung (SCLC) were collected from online databases. Using 374 of 451 HKGs, differentially expressed genes between pairs of sample types were determined via two-sided, homoscedastic t-test. Principal component analysis and hierarchical clustering classified normal lung and lung cancers subtypes according to relative gene expression variations. We used uni- and multi-variate cox-regressions to identify significant predictors of overall survival in AD patients. Classifying genes were selected using a set of training samples and then validated using an independent test set. Gene Ontology was examined by PANTHER. Results This study showed that the differential expression patterns of 242, 245, and 99 HKGs were able to distinguish normal lung from AD, SCLC, and SQCLC, respectively. From these, 70 HKGs were common across the three lung cancer subtypes. These HKGs have low expression variation compared to current lung cancer markers (e.g., EGFR, KRAS) and were involved in the most common biological processes (e.g., metabolism, stress response). In addition, the expression pattern of 106 HKGs alone was a significant classifier of AD versus SQCLC. We further highlighted that a panel of 13 HKGs was an independent predictor of overall survival and cumulative risk in AD patients. Discussion Here we report HKG expression patterns may be an effective tool for evaluation of lung cancer states. For example, the differential expression pattern of 70 HKGs alone can separate normal lung tissue from various lung cancers while a panel of 106 HKGs was a capable class predictor of subtypes of non-small cell carcinomas. We also reported that HKGs have significantly lower variance compared to traditional cancer markers across samples, highlighting the robustness of a panel of genes over any one specific biomarker. Using RNA-seq data, we showed that the expression pattern of 13 HKGs is a significant, independent predictor of overall survival for AD patients. This reinforces the predictive power of a HKG panel across different gene expression measurement platforms. Thus, we propose the expression patterns of HKGs alone may be sufficient for the diagnosis and prognosis of individuals with lung cancer.
Selective attention as a protagonist in contemporary workplace stress: implications for the interruption age

Background and Objectives: The ubiquity of instant messages and email notifications in contemporary work environments has opened a Pandora's Box. This box is filled with countless interruptions coming from laptops, smartphones, and other devices, all of which constantly call for employees’ attention. In this interruption era, workplace stress is a pervasive problem. To examine this problem, the present study hypothesizes that the three-way interaction among the frequency with which interrupting stimuli appear, their salience, and employees’ deficits in inhibiting attentional responses to them impacts mental workload perceptions, ultimately leading to stress. The study, further, probes a related form of self-efficacy as a potential suppressor of interruption-based stress. Design: The study used a 2 (low vs. high frequency) × 2 (low vs. high salience) mixed model design. Methods: The 128 subjects completed a test of their inhibitory deficits and rated their mental workload perceptions and experiences of stress following a computer-based task. Results: Inhibitory deficits and increased interruption salience can alter the perception of mental workload in contemporary work environments for the worse, but interruption self-efficacy can help offset any resulting interruption-based stress. Conclusions: This study extends the literatures on work interruptions as well as on stress and coping in the workplace.
Alcohol use disorders in primary care patients in Cagliari, Italy.

AIMS To evaluate the number of subjects with possible alcohol use disorders (SPAUD) among primary care patients in Cagliari, Sardinia, Italy, by means of the self-administration of Alcohol use disorder identification test (AUDIT) and CAGE questionnaires. METHODS 939 patients waiting in 10 surgeries of primary care physicians were asked to take part in the study. A sample of 309 women and 197 men (total 506), aged between 18 and 65 years, agreed to participate and completed both questionnaires. SPAUD were defined as those achieving cut-off scores of 5 for AUDIT and/or 1 for CAGE. RESULTS Seventy-nine (15.61%) patients were SPAUD, achieving a positive score in at least one questionnaire. Fifty-six (11.07%) and forty-six (9.09%) patients yielded positive results with AUDIT and CAGE, respectively. Twenty-three (4.55%) patients were positive at both AUDIT and CAGE. Significantly higher proportions of men than women were recorded among SPAUD. CONCLUSIONS The results of the present survey indicate a high number of SPAUD in a sample of primary care settings in Cagliari, closely similar to the occurrence of alcohol use disorders estimated in several other community-based primary care clinics in Western Countries.
Critical Swimming Speed and Behavior of Juvenile Shovelnose Sturgeon and Pallid Sturgeon

The swimming performance of hatchery-reared. juvenile shovelnose sturgeon Scaphirhynchus plarorynchus and pallld sturgeon S. albus was studied in a laboratory swim tunnel at 20°C and 1O0C. The mean 30-min critical swimming speed was not significantly different between species at either temperature (36.9 crd s for shovelnose sturgeon and 35.9 cm/s for pallid utur-geon at 20°C. 19.4 cmls for shovelnose sturgeon and 15.0 c d s for pallid sturgeon at 10°C), Free swimming (swimming without contact with the substrate) waa observed less than 18% of the time at speeds greater than 15 cmls. As speed increased, pallid sturgeon Swam gig-nificantly less in the water column at 20°C; however, speed had no effect on percent free swimming among shovelnose sturgeon at 20°C. The results of this utudy Indicate thal, over the temperature and size range tested, shovclnose sturgeon and pallid sturgcon probably do not segregate in rivers due to different swimming or station-holding abilities Shovelnose sturgeon Scaphirhynchus platoryn-char and pallid sturgcon S. alhus are sympatric in the main-stem Mississippi and Missouri rivers and are: generally associated with flowing water htlbi-tats in or near the main channel (Bailey and Cross 1954). Adults of both species are known to use relatively low-velocity areas astiociated with dike fields, sand bars, and islands (Carlson et al. (Scaphirhynchus spp.) in the wild are infrequent, and young pallid sturgeon have only recently been sampled. Juvenile (5.0-21.0 cm) shovelnose sturgeon and pallid sturgeon have been collected by bottom trawling on the sand flats of the Mississippi River, primarily in main channel border areas whcre velocities 20 cm above the b o t t ~ m ranged from 20 to 80 crnls; sand troughs were usually present in general capture locationssource Monitoring Program, personal communication). The extent of overlap in habitat use by river sturgeons remains relatively unknown (particularly for the early life stages), but a potential consequence of sharing habitat would be an in-terspecific competition for resources. Fish occupying similar habitats partition resources along a trophic gradient or through differences in the temporal or spatial use of the habitat (Roes 1986). Closely related, sympatric species may segregate spatially in lotic environments through limits in their ability to occupy increased velocities (e.g., Peakc et al. 1997). While most available information suggests that river sturgeons at a given life stage occupy the same general habitats , in some field studics adult pallid sturgeon were found to occupy faster currents and to …
Dimensions in appreciation of car interior design

SUMMARY We report two studies in which the interplay between stimulus properties and perceiver characteristics in the appreciation car interiors was investigated. In Experiment 1 three design components, complexity, curvature and innovativeness, which are all thought to affect design appreciation were combined in a fully factorial design. All dimensions were confirmed to affect ratings, and curvature and innovativeness particularly affected the attractiveness ratings. Curved and non-innovative designs were generally preferred. Moreover, participants who were particularly interested in art were more sensitive to curvature and innovativeness. In Experiment 2 two dimensions of Experiment 1 were replicated using similar stimuli. Moreover, the specific effects of a design knowledge treatment were investigated. Results replicated the preference for curved and non-innovative (rather classic) designs. The treatment had only small effects, which support a general rather than dimension-specific effects of cognitive pre-information. Copyright # 2005 John Wiley & Sons, Ltd. Car interior design allows manufacturers to select from a wide choice of fundamental design principles. Some principles are eminent parts of design philosophy of a certain brand; others represent more abstract decisions about the appearance of single car models. As exterior design is often dominated by technical constraints such as the air drag coefficient, interior design often allows designers to use more individual and aesthetically justified designs (Karlsson, Aronsson, & Svensson, 2003). In order to sell the product, the appearance nowadays has a major importance for the consumer. Thus, aesthetic and design are decisive buy-arguments in markets in which the technical level of competing products is very similar (Demirbilek & Sener, 2003). This is particularly and increasingly the case with cars. Moreover, the impact of design might also depend on different personalities. People more interested in aesthetics and less attached to technical properties might react more positive to innovative and modern design while others may express rather conservative attitudes in choosing more conventional design products. Consequently, understanding aesthetic appreciation of industrial products is an important aspect of psychology of aesthetics and its application in consumer related fields (Liu, 2003). In psychology, topics of aesthetic appreciation were investigated mainly in the field of empirical or experimental aesthetics.
The prevalence of allergic diseases among children with asthma: What is the impact on asthma control in South East Nigeria?

Background: Allergic diseases are known to occur in children with asthma and its coexistence with asthma may impact on asthma control in affected children living in a low-income country. The study is to determine the allergic profile of children with asthma and the association with asthma control and attendant social risk factors. Materials and Methods: This was a cross-sectional study of consecutively enrolled children with physician diagnosed asthma, attending clinics in a tertiary center in Nigeria. The presence of asthma, allergy types, and asthma control levels were determined using the Gobal initiative on asthma (GINA), international study of asthma and allergy in childhood and asthma control test questionnaires, respectively. Results: There were 207 children with asthma enrolled from the Pediatric Asthma Clinic at University of Nigeria Teaching Hospital, Enugu. The median age was 10 years and interquartile range of 7–11 years. There were 127 (61.4%) from middle and high socioeconomic class and 86.5% who lived in the urban areas. Of the study participants, 41.5% had one or more allergy symptoms; rhinitis (33.3%), conjunctivitis (29.0%), and dermatitis (7.2%). Allergy symptoms persisted from infancy in 55.9%. Children from large families had a lower prevalence of allergies. Having any allergy symptom and belonging to a small-sized family were both associated with asthma exacerbations. Most children studied, (69.1%) had their asthma under control. Allergy persistence from infancy and type of allergy were not significantly associated with the level of asthma control. Conclusion: Allergic diseases are common in children with asthma in our environment, but did not significantly impact on asthma control. Socioeconomic factors such as urbanization and family size had effects on the achievement of asthma control but not on allergy status.
Evaluating the Complementarity of Communication Tools for Learning Platforms

Abstract: Due to the constant innovations in communications tools, several educational institutions are continually evaluating the adoption of new communication tools (NCT) for their adopted learning platforms (LP). Notably, many educational institutions are interested in checking if NCT is bringing benefits in their teaching and learning process. We can state an important problem that tackles this interest as for how to identify when NCT is providing a significantly different complementary communication flow concerning the current communication tools (CCT) provided at LP. This paper presents the Mixed Graph Framework (MGF) to address the problem of measuring the complementarity of an NCT in the scenario where some CCT is already established. Since we are interested in the methodological process, we evaluated MGF using synthetic data. Our experiments observed that the MGF was able to identify whether an NCT produces significant changes in the overall communications of an LP according to some centrality measures.
Constitutive explanations in neuroeconomics: principles and a case study on money

So far, the methodological debate about neuroeconomics rarely refers to original methodological positions in the neurosciences. I confront one of the most influential ones, the constitutive explanations or mechanism approach, with methodological claims that directly relate the economic model of choice with neuronal embodiments, represented by Glimcher’s influential work. Constitutive explanations are composite and non-reductionist, therefore allow for recognizing complex causal interactions between basal neuronal phenomena and cognitive structures, also involving external symbolic media. I demonstrate the power of this methodology in discussing the example of money, which Glimcher posits as one of the most important research tasks in further developing neuroeconomics. Whereas Glimcher justifies neuroscientific reductionism by presenting an evolutionary rationale for deploying formal economic models on particular modules enabling choice, the case of money reveals the need for mechanistic explanations that include a substantial role for cultural evolution, though recognizing causal interactions with basal neuronal mechanisms.
The Problem of Reading and Reading Culture Improvement of Students-Bachelors of Elementary Education in Modern High Institution.

This article is aimed to study the problems of reading and improve reading culture of students-bachelors of elementary education in modern high institutions and development of the most effective methods and techniques for improving of reading culture of students in the study of Humanities disciplines. The leading method to the study of this problem is a pedagogical experiment (ascertainment, formation and control stages of experiment), and the method of expert estimations, statistical processing of quantitative research results. The article identifies the most effective methodological techniques of reading culture improvement of undergraduate students, future specialists of elementary education in their learning process at the University; We offered the methodology of reading culture improvement for the undergraduate students of "Elementary education" profile, providing thoughtful skill of reading of the works of various styles and genre, creative reading skill, formation of reading competence of students.