Miracle-dz/UniFAR-FTUs huggingface dataset:
CYP2E1 genotyping in renal cell/urothelial cancer patients in comparison with control populations.

OBJECTIVE Genetic polymorphisms in enzymes involved in carcinogen metabolism have been found to influence susceptibility to cancer. Ethanol-inducible CYP2E1 is an enzyme of major toxicological interest because it metabolizes several drugs, precarcinogens, and solvents to reactive metabolites. In the present investigation, we studied the cytochrome P450 2E1 genetic polymorphism in renal cell/urothelial cancer patients in comparison with healthy control populations in the regions of Jena and Halle in Germany. PATIENTS AND MATERIAL DNA of peripheral white blood cells was isolated both from 273 renal cell/urothelial cancer patients and 298 controls from the regions of Jena and Halle. METHOD We focused on polymorphisms in the promoter region and intron 6 of the CYP2E1 gene. The polymorphims were identified as restriction fragment length polymorphisms (RFLPs) by polymerase chain reaction (PCR) and subsequently applying the restriction enzymes PstI/RsaI and DraI. RESULTS In the region of Jena as well as of Halle, the frequency distributions of the PstI/RsaI, DraI, and combined DraI + PstI/RsaI genotypes showed no significant differences between controls and renal cell/urothelial cancer patients. We did not find significant differences between Jena and Halle. 86.7% of all subjects with a homozygote PstI/RsaI genotype also carried a homozygote DraI genotype, whereas 5.2% of all subjects with a heterozygote PstI/RsaI genotype also carried a heterozygote DraI genotype. The heterozygote genotype of PstI/RsaI polymorphism always determines the heterozygote genotype of DraI polymorphism. Our results failed to demonstrate any differences in the distribution of CYP2E1 polymorphisms between renal cell/urothelial cancer patients and controls. CONCLUSION Summing up, our results show that CYP2E1 genotype cannot predict risk for renal cell/urothelial cancer in the population from 2 different regions in Germany. The results demonstrate a lack of association between CYP2E1 genetic polymorphism and renal cell cancer/urothelial cancer.
Territorial features, disorder and fear of crime in residential neighbourhoods in Malaysia: testing for multigroup invariance

This research examined the relationships between territoriality, disorder, crime, perceived risk and fear of crime and determined whether these relationships are constant between neighbourhoods. Questionnaire surveys and on-site observations were conducted on a sample of 320 residents from two neighbourhoods in Malaysia. Tests for invariance were conducted to determine whether coefficients differed across neighbourhoods. Confirmatory factor analytic models of the constructs exhibited adequate fit following multiple criteria within each and across samples. Results from these analyses suggested that the relationships between disorder and perceived risk, victimisation, and fear of crime were significant in both samples. Although high territoriality was associated with low-crime experiences in the low-crime area, no significant relationship was observed in the high-crime area. The findings illustrated the importance of examining territoriality and perceptions of disorder within the neighbourhood contexts.
Ends of locally symmetric spaces with maximal bottom spectrum

Abstract Let X be a symmetric space of non-compact type and Γ\X a locally symmetric space. Then the bottom spectrum λ 1(Γ\X) satisfies the inequality λ 1(Γ\X) ≦ λ 1(X). We show that if equality λ 1(Γ\X) = λ 1(X) holds, then Γ\X has either one end, which is necessarily of infinite volume, or two ends, one of infinite volume and another of finite volume. In the latter case, Γ\X is isometric to ℝ1 × N endowed with a multi-warped metric, where N is compact.
LincRNA-p21: Implications in Human Diseases

Long noncoding RNAs (lncRNAs), which lack significant protein-coding capacity, regulate various biological processes through diverse and as yet poorly understood molecular mechanisms. However, a number of studies in the past few years have documented important functions for lncRNAs in human diseases. Among these lncRNAs, lincRNA-p21 has been proposed to be a novel regulator of cell proliferation, apoptosis and DNA damage response, and involved in the initiation and progression of human diseases. In this review, we summarize the current knowledge of lincRNA-p21, mainly focus on the known biological functions and its underlying mechanisms. Moreover, we highlight the growing body of evidences for the importance of lincRNA-p21 in diverse human diseases, which indicate lincRNA-p21 as a potential diagnostic marker and/or a valuable therapeutic target for these diseases.
Effect of Physical Inactivity on Cognitive Performance after 2.5 Years of Follow-Up Longitudinal Results from the Survey of Health, Ageing, and Retirement (SHARE)

Objective: To examine the association between physical activity and cognitive performance in a longitudinal study. Methods: We analyzed data from 17.333 noninstitutionalized persons aged 50 years or older in 11 European countries who participated in Wave 1 (2004/2005) and Wave 2 (2006/2007) of the Survey of Heath, Ageing, and Retirement in Europe (SHARE). Physical activity at baseline was measured as self-reported frequency of sports or activities requiring vigorous activity, and frequency of activities demanding a moderate level of activity. Cognitive function was measured at baseline and after a mean of 2.5 years of follow-up by delayed word recall and verbal fluency tests. The effects of physical activity at baseline on cognitive performance at follow-up were assessed in hierarchical multilevel random effects models adjusted for sociodemographic variables (age, education), somatic comorbidities, functional impairment (basic and instrumental activities of daily living, maximum grip strength), depressive symptoms, and body mass index. Results: After adjusting for potential confounders, we found physical inactivity (neither moderate nor vigorous) to be associated with a higher rate of cognitive decline over a mean follow-up of 2.5 years (β = -1.79 (SE = 0.17) for verbal fluency; β = -0.35 (SE = 0.04) for delayed word recall). Further analyses showed that vigorous activities more than once a week were especially related to change in cognition over time. Conclusion: Engagement in moderate and vigorous physical activities protects against cognitive decline in older age. Participation in physical activities may be of particular importance when other risk factors for cognitive decline are present.
Stabilization of erythrocytes against oxidative and hypotonic stress by tannins isolated from sumac leaves (Rhus typhina L.) and grape seeds (Vitis vinifera L.)

Erythrocytes are constantly exposed to ROS due to their function in the organism. High tension of oxygen, presence of hemoglobin iron and high concentration of polyunsaturated fatty acids in membrane make erythrocytes especially susceptible to oxidative stress. A comparison of the antioxidant activities of polyphenol-rich plant extracts containing hydrolysable tannins from sumac leaves (Rhus typhina L.) and condensed tannins from grape seeds (Vitis vinifera L.) showed that at the 5–50 μg/ml concentration range they reduced to the same extent hemolysis and glutathione, lipid and hemoglobin oxidation induced by erythrocyte treatment with 400 μM ONOO− or 1 mM HClO. However, extract (condensed tannins) from grape seeds in comparison with extract (hydrolysable tannins) from sumac leaves stabilized erythrocytes in hypotonic NaCl solutions weakly. Our data indicate that both hydrolysable and condensed tannins significantly decrease the fluidity of the surface of erythrocyte membranes but the effect of hydrolysable ones was more profound. In conclusion, our results indicate that extracts from sumac leaves (hydrolysable tannins) and grape seeds (condensed tannins) are very effective protectors against oxidative damage in erythrocytes.
Exploiting Contextual Information for Fine-Grained Tweet Geolocation

The problem of fine-grained tweet geolocation is to link tweets to their posting venues. We solve this in a learning to rank framework by ranking candidate venues given a test tweet. The problem is challenging as tweets are short and the vast majority are non-geocoded, meaning information is sparse for building models. Nonetheless, although only a small fraction of tweets are geocoded, we find that they are posted by a substantial proportion of users. Essentially, such users have location history data. Along with tweet posting time, these serve as additional contextual information for geolocation. In designing our geolocation models, we also utilize the properties of (1) spatial focus where users are more likely to visit venues near each other and (2) spatial homophily where venues near each other tend to share more similar tweet content, compared to venues further apart. Our proposed model significantly outperforms the content-only approaches.
Taking Care of Business: HMOs That Spend More on Administration Deliver Lower-Quality Care

The authors analyzed health maintenance organizations' administrative costs and quality measures from the National Committee for Quality Assurance's Quality Compass database for the years 1997–2000. HMOs with higher administrative overhead had consistently worse quality scores in univariate analysis. Multivariate analyses controlling for geographic region (all years) and HMO model type (1997 and 1998 analyses only) confirmed that higher administrative costs were associated with lower quality. Excess HMO bureaucracy is not only wasteful but harmful.
Evidence for In Vitro Binding of Pectin Side Chains to Cellulose1

Pectins of varying structures were tested for their ability to interact with cellulose in comparison to the well-known adsorption of xyloglucan. Our results reveal that sugar beet (Beta vulgaris) and potato (Solanum tuberosum) pectins, which are rich in neutral sugar side chains, can bind in vitro to cellulose. The extent of binding varies with respect to the nature and structure of the side chains. Additionally, branched arabinans (Br-Arabinans) or debranched arabinans (Deb-Arabinans; isolated from sugar beet) and galactans (isolated from potato) were shown bind to cellulose microfibrils. The adsorption of Br-Arabinan and galactan was lower than that of Deb-Arabinan. The maximum adsorption affinity of Deb-Arabinan to cellulose was comparable to that of xyloglucan. The study of sugar beet and potato alkali-treated cell walls supports the hypothesis of pectin-cellulose interaction. Natural composites enriched in arabinans or galactans and cellulose were recovered. The binding of pectins to cellulose microfibrils may be of considerable significance in the modeling of primary cell walls of plants as well as in the process of cell wall assembly.
Damped Lyα Absorber and the Faint End of the Galaxy Luminosity Function at High Redshift

We combine predictions for several hierarchical cosmogonies with observational evidence on damped Lyα systems (DLASs) to establish a correspondence between the high-redshift galaxy population and the properties of DLASs. We assume that high-redshift galaxies and damped Lyα systems are hosted by the same dark matter halos and require consistency between the predicted halo space density, the rate of incidence and the velocity width distribution of damped Lyα systems, and the observed galaxy luminosity function at the bright end. We arrive at the following results: (1) predicted impact parameters between the damped absorption system and the luminous parts of the absorbing galaxy are expected to be very small (0.″3-1'') for most galaxies; (2) luminosities of galaxies causing damped absorption are generally fainter than m ℛ = 25, and damped Lyα systems are predicted to sample preferentially the outer regions of galaxies at the faint end of the galaxy luminosity function at high redshift. Therefore, DLASs should currently provide the best probe of the progenitors of normal present-day galaxies.
Augmented Reality in the Surgery of Cerebral Aneurysms: A Technical Report

BACKGROUND: Augmented reality is the overlay of computer-generated images on real-world structures. It has previously been used for image guidance during surgical procedures, but it has never been used in the surgery of cerebral aneurysms. OBJECTIVE: To report our experience of cerebral aneurysm surgery aided by augmented reality. METHODS: Twenty-eight patients with 39 unruptured aneurysms were operated on in a prospective manner with augmented reality. Preoperative 3-dimensional image data sets (angio-magnetic resonance imaging, angio-computed tomography, and 3-dimensional digital subtraction angiography) were used to create virtual segmentations of patients' vessels, aneurysms, aneurysm necks, skulls, and heads. These images were injected intraoperatively into the eyepiece of the operating microscope. An example case of an unruptured posterior communicating artery aneurysm clipping is illustrated in a video. RESULTS: The described operating procedure allowed continuous monitoring of the accuracy of patient registration with neuronavigation data and assisted in the performance of tailored surgical approaches and optimal clipping with minimized exposition. CONCLUSION: Augmented reality may add to the performance of a minimally invasive approach, although further studies need to be performed to evaluate whether certain groups of aneurysms are more likely to benefit from it. Further technological development is required to improve its user friendliness. ABBREVIATION: MCA, middle cerebral artery
On agile performance requirements specification and testing

Underspecified performance requirements can cause performance issues in a software system. However, a complete, upfront analysis of a software system is difficult, and usually not desirable. We propose an evolutionary model for performance requirements specifications and corresponding validation testing. The principles of the model can be integrated into agile development methods. Using this approach, the performance requirements and test cases can be specified incrementally, without big upfront analysis. We also provide a post hoc examination of a development effort at IBM that had a high focus on performance requirements. The examination indicates that our evolutionary model can be used to specify performance requirements such that the level of detail is commensurate with the nature of the project. Additionally, the IBM experience indicates that test driven development-type validation testing corresponding to the model can be used to determine if performance objectives have been met
THE TRADE-OFF AND PECKING ORDER THEORIES : SOME UK EVIDENCE First draft : 28 May 2004 This draft : 20 July 2005

In this paper, we conduct empirical tests for the two leading but contradicting theories of capital structure: the trade-off and the pecking order theories. To examine former theory, we use a partial adjustment model, and an error correction model as a generalised specification of the partial adjustment process. This framework allows us to nest the cash flow deficit variable necessary to examine the pecking order theory. The empirical models are estimated by IV and GMM methods, which are argued to yield consistent estimates for dynamic panel data. The finding suggests that the trade-off theory holds well and consistently outperforms the pecking order theory. JEL Classification: G32.
The Prevalence of Coping Behaviour, Posttraumatic Growth and Psychological Well-Being in Women who Experienced Childhood Sexual Abuse

This study investigated the prevalence of coping behaviour, posttraumatic growth and psychological well-being in adult South African women (n=60, mean age=32, ethnicity=70% European, 28% African and 2% Asian descent). Specifically, the study considered the prevalence of constructive coping, posttraumatic growth and psychological well-being with a history of childhood sexual abuse. All participants self-reported being sexually abused before the age of 18 years. They completed measures of coping, posttraumatic growth, and psychological well-being, in a cross-sectional survey design. Results showed moderate to high correlations among scales indicating conceptual coherence as indicators of constructive coping, posttraumatic growth and psychological wellness. About 58% of participants manifested constructive coping, 60% manifested posttraumatic growth, and 42% manifested psychological well-being. These women survivors of childhood sexual abuse had higher levels of posttraumatic growth than reported in previous studies.
Get Back into that Kitchen, Woman: Management Conferences and the Making of the Female Professional Worker

Conferences are a little studied aspect of working lives. In this article we explore how management conferences contribute to the continuing imbalance of power between men and women in management. We analyse data gathered from a reflexive ethnographic study of a management conference. We show that women arrive at conferences as knowing subjects, able easily to occupy the subject position of conference participant, but they are then subjected to processes of infantilization and seduction. They are made to feel scared and are given the order, as were their mothers and grandmothers: get back to the kitchen. We avoid using a theoretical explanation for these findings, preferring to offer them without much explanation, for we favour instead a political approach, and we use the findings as a way of making a call to arms to change the ways in which conferences are hostile to women.
Is it quinine TTP/HUS or quinine TMA? ADAMTS13 levels and implications for therapy

Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine “hypersensitivity. ” When schistocytes are present it is frequently termed “quinine‐associated TTP/HUS. ” A severe deficiency of the vWF‐cleaving protease, ADAMTS13, is associated with idiopathic TTP. A previous study of patients with “quinine‐associated TTP/HUS” found that ADAMTS13 activities were not abnormal in 12/12 patients. A retrospective review of TTP patients with quinine‐associated thrombotic microangiopathy (TMA) for whom ADAMTS13 was measured before plasma exchange was performed. Six patients were identified. All were females (age range: 43 to 73, mean = 61.7 years) and had taken quinine for leg cramps. Four of the six experienced renal failure requiring dialysis. Five of the patients had D‐Dimers levels measured, all were elevated. In four patients the levels were ≥18 times the upper limit of normal. ADAMTS13 was normal in four patients and mildly decreased in two patients. We conclude that while thrombocytopenia and schistocytosis can be seen in quinine‐associated TTP/HUS, the pathophysiology seems to be distinct from that seen in most cases of idiopathic TTP (i.e., severely decreased ADAMTS13 with an inhibitor). We recommend that a TMA in association with quinine be consistently referred to as quinine‐associated thrombotic microangiopathy (quinine‐TMA) to better distinguish this entity from idiopathic TTP. The use of plasma exchange in quinine‐TMA is called into question. J. Clin. Apheresis, 2009. © 2009 Wiley‐Liss, Inc.
Speech recognition technology for individuals with disabilities

There are estimated to be about 15 million people in the United States alone who are disabled to some degree, and it has been hypothesized that at least 10% of the world's population experience some sort of physical impairment. Although such statistics are always open to debate, this does not detract from the suggestion that one of the most promising application areas for Automatic Speech Recognition (ASR) is in helping people with disabilities. It is within this context that the advantages of speech recognition are discussed, both in general and with specific relation to this user group. During the last decade, the development of more sophisticated techniques for analyzing incoming speech combined with the increased processing power of microcomputers has resulted in improved recognition performance. Consequently, speech recognizers are now either operational or being considered in a variety of industrial tasks and in office and aerospace environments. ASR applications specific to disabled users are revie.
The Discursive Turn in School Desegregation

This study addresses changes in the public conversation on school desegregation since the early 1970s. It applies the concept of discursive opportunity structure to the debates on desegregation in order to illustrate how a dynamic and balanced conversation, which involved both positive and negative views on the policy, has evolved into an anemic and overly negative one. The study relies on insights from social movement research on political opportunity structures for debates on contentious issues and on interpretive framing processes. Several inferences are offered on the nature of the discursive turn in desegregation at the national level, followed by a detailed analysis of desegregation and resegregation in Cleveland from 1973 to 1998. This involves the systematic examination of local newspaper coverage and also draws on court documents, administrative student records, and census information. The findings suggest that political and social structural factors that have restricted the chances for a balanced conversation have also complicated desegregation implementation and may have undermined the policy’s intended student benefits. By the 1990s even the most dedicated advocates had withdrawn from the debate, allowing the conversation to atrophy and become dominated by critical views. As a result, public education has risked failing to address the ill effects of resegregation and to produce reforms that foster quality schools for all.
Cognitive functioning early after surgery of gliomas in eloquent areas.

OBJECT Patients with gliomas frequently have cognitive deficits, and surgery can exacerbate these deficits. Preoperative assessment is therefore crucial in patients undergoing surgery for glioma in eloquent areas, because the proximity of functional areas increases the risk of permanent postoperative cognitive disturbances. Although pre- and postoperative language and motor function in patients with glioma have been investigated frequently, data on good cognition studies are scarce. Most studies have focused on clinical neurological functioning or have only used brief neurological instruments. The authors investigated whether surgery for glioma in eloquent areas influences cognition early after surgery, by using an elaborate test protocol. METHODS Twenty-eight patients with gliomas of the left hemisphere in language and nonlanguage areas were assessed before and 3 months after surgery with a comprehensive neuropsychological test protocol. The authors performed a correlation analysis between change in cognitive performance and tumor characteristics (that is, location, volume, pathological features, and histological grade) and between cognitive change and treatment-related factors (the extent of the resection and postoperative treatment with chemo- and radiotherapy). RESULTS Both pre- and postoperatively, the mean performance of the patients was worse than the performance of the normal population in the language domain, the memory domain, and the executive functions (p < 0.05). Postoperatively, a decline was found in the language domain (t = 2.34, p = 0.027) and in the executive functions (t = 2.45, p = 0.022). However, cognitive change postsurgery was influenced by the location of the tumor; the decrease of cognitive score in the language domain was only observed in patients with tumors in or close to language areas (t = 2.33, p = 0.029). No effect on cognitive change was found for the other tumor characteristics and treatment-related factors. CONCLUSIONS This study underlines the importance of the use of a neuropsychological test protocol before and after surgery in patients with glioma, because several tasks in the domains of language, memory, and executive functions appeared to deteriorate after surgery. Tumor resection in language areas increases the risk of cognitive deficits in the language domain postoperatively.