Miracle-dz/UniFAR-FTUs huggingface dataset:
Social movements and the experience of market-led agrarian reform in Brazil

Abstract This article examines the experience of market-led agrarian reform ( mlar ) implementation in Brazil. In doing so, it will also analyse the complexity of the Brazilian agrarian situation, the political struggles around the fight for land and the complexity of political forces involved in the contestation. The article examines the origins, implementation process and outcomes of mlar . The paper also examines the current impasse in resolving the agrarian question in the country especially those related to the strengthening of land property rights at the same time that there are increasing demands for land by social movements, putting into broader context the current political and operational difficulties being encountered by mlar .
Acute mountain sickness, dehydration, and bicarbonate clearance: preliminary field data from the Nepal Himalaya.

BACKGROUND In 1999, Basnyat et al. published preliminary data demonstrating an inverse correlation between hydration status and acute mountain sickness during an epidemiological study performed in the vicinity of Mount Everest. To expand on these findings, we have re turned to the Langtang area of the Nepal Himalaya to perform more specific studies of altitude illness related to dehydration and hypoxemia using urine studies, pulse oximetry, and physical examination. HYPOTHESIS Dehydration will incite physiological changes aimed at the preservation of vascular volume homeostasis characterized by the production of sodium and water sparing hormones. As sodium is reabsorbed in the kidney, bicarbonate anion is also reabsorbed resulting in insufficient bicarbonate anion excretion by the kidney leading to an incomplete compensation for altitude induced hypocapnic alkalosis and the development of clinical disease. METHODS Estimates of intravascular volume (urine specific gravity), oxygen saturation (pulse oximetry), urinary bi carbonate excretion (urine pH), and AMS (Lake Louise Score) were collected from Hindu pilgrims at 4243 m during an annual sacred festival at Lake Gosinkunda. RESULTS Worsening altitude illness approx imated by increasing Lake Louise Score was associated with increasing urine specific gravity (p = 0.043), decreasing oxygen saturation (p = 0.020), and decreasing urine pH (p = 0.040) after rapid ascent to 4243 m. CONCLUSIONS Worsening altitude illness, indicated by increasing Lake Louise score, was associated with increasing measures of dehydration, hypoxemia, and urine acidity.
Rural tourism in Spain.

The paper describes the rapid recent growth in rural tourism facilities in Spain and attempts to account for the regional variations that exist. The range of activities involved in rural tourism is described and a significant trend towards the development of ‘active’ leisure pursuits in rural areas is identified. This clearly implies a major change in the use of the countryside, albeit in specific locations, but therefore calls into question the assertion of some scholars that rural restructuring is not a feature of contemporary Spain. In assessing the wider impact of rural tourism policies as part of overall rural development, however, it is clear that the main beneficiaries are not necessarily local residents. Copyright © 2004 John Wiley & Sons, Ltd.
Short Constraints, Difference of Opinion and Stock Returns

We present a new approach to analyzing the effect of short constraints on stock returns. Starting from the theory, we measure how short constrained a stock is by looking at month end outstanding short positions and other measures that proxy for heterogeneity in beliefs and ease of shorting a stock. Our proxies include analyst's forecast dispersion, institutional holdings, turnover (among others). Using monthly data for the period 1992 to 2000 on NASDAQ and NYSE stocks, we form portfolios using our measure of short constraints. We find that portfolio of stocks that are short constrained earn lower returns. We also observe that the most constrained portfolio earns a significant negative one month ahead abnormal return, after accounting for risk. One can interpret this evidence as being supportive of the common notion that constrained stocks might be priced higher today. We believe our work provides evidence that short constraints matter for asset returns. It also confirms the notion that arbitrage can sometimes be rendered ineffective in financial markets because of market frictions like short constraints which can lead to abnormal returns in stocks that are constrained. This is consistent with the idea of Limited Arbitrage of Shleifer and Vishny.
Publication Bias in the Economic Freedom and Economic Growth Literature

The impact of institutions on economic performance has attracted significant attention from researchers, as well as from policy reformers. A rapidly growing area in this literature is the impact of economic freedom on economic growth. The aim of this paper was to explore publication bias in this literature by means of traditional funnel plots, meta-significance testing, as well as by bootstrapping these meta-significance tests. When all the available estimates are combined and averaged, there seems to be evidence of a genuine and positive economic freedom - economic growth effect. However, it is also shown that the economic freedom - economic growth literature is tainted strongly with publication bias. The existence of publication bias makes it difficult to identify the magnitude of the genuine effect of economic freedom on economic growth. The paper explores the differences between aggregate and disaggregate measures of economic freedom and shows that selection effects are stronger when aggregate measures are used. Copyright Blackwell Publishers Ltd, 2005.
Research Pathways of Forest Above-Ground Biomass Estimation Based on SAR Backscatter and Interferometric SAR Observations

Estimation of forest biomass with synthetic aperture radar (SAR) and interferometric SAR (InSAR) observables has been surveyed in 186 peer-reviewed papers to identify major research pathways in terms of data used and retrieval models. Research evaluated primarily (i) L-band observations of SAR backscatter; and, (ii) single-image or multi-polarized retrieval schemes. The use of multi-temporal or multi-frequency data improved the biomass estimates when compared to single-image retrieval. Low frequency SAR backscatter contributed the most to the biomass estimates. Single-pass InSAR height was reported to be a more reliable predictor of biomass, overcoming the loss of sensitivity of SAR backscatter and coherence in high biomass forest. A variety of empirical and semi-empirical regression models relating biomass to the SAR observables were proposed. Semi-empirical models were mostly used for large-scale mapping because of the simple formulation and the robustness of the model parameters estimates to forest structure and environmental conditions. Non-parametric models were appraised for their capability to ingest multiple observations and perform accurate retrievals having a large number of training samples available. Some studies argued that estimating compartment biomass (in stems, branches, foliage) with different types of SAR observations would lead to an improved estimate of total biomass. Although promising, scientific evidence for such an assumption is still weak. The increased availability of free and open SAR observations from currently orbiting and forthcoming spaceborne SAR missions will foster studies on forest biomass retrieval. Approaches attempting to maximize the information content on biomass of individual data streams shall be pursued.
The effects of vitamin D plus calcium supplementation on metabolic profiles, biomarkers of inflammation, oxidative stress and pregnancy outcomes in pregnant women at risk for pre-eclampsia.

BACKGROUND The present study was designed to examine the effects of vitamin D plus calcium administration on metabolic profiles and pregnancy outcomes among women at risk for pre-eclampsia. METHODS In a prospective, double-blind, placebo-controlled trial, 60 women at risk for pre-eclampsia were randomised to take either 50 000 IU vitamin D3 every 2 weeks plus 1000 mg day(-1) calcium supplements (as calcium carbonate) (n = 30) or to receive placebos at the same times (n = 30) from 20 to 32 weeks of gestation. Fasting blood samples were taken at baseline and 12 weeks after intervention to determine related variables. Newborn anthropometric measurements were determined. RESULTS Taking combined cholecalciferol and calcium supplements, compared to placebo, led to significant reductions in fasting plasma glucose (FPG) [mean (SD)] [-5.7 (5.5) versus -0.6 (12.6) mg dL(-1) , P = 0.04], serum insulin concentrations [-2.8 (6.0) versus +7.7 (9.8) μIU mL(-1) , P < 0.001], homeostasis model of assessment-insulin resistance [-0.8 (1.3) versus +1.6 (2.2), P < 0.001], homeostatic model assessment-beta cell function [-8.2 (25.8) versus +32.6 (41.3, P < 0.001] and a significant rise in quantitative insulin sensitivity check index score [+0.02 (0.02) versus -0.02 (0.02, P < 0.001]. Additionally, pregnant women who received cholecalciferol plus calcium supplements had increased serum high-density lipoprotein (HDL)-cholesterol [+4.6 (8.3) versus -2.9 (7.7) mg dL(-1) , P = 0.001] and plasma total glutathione (GSH) concentrations [+23.4 (124.0) versus -94.8 (130.2) μm, P = 0.001] compared to placebo. However, after adjustment for the baseline levels, maternal age and baseline body mass index, the effects on FPG levels (P = 0.13) and systolic blood pressure (P = 0.13) disappeared. CONCLUSIONS Vitamin D plus calcium administration for 12 weeks had beneficial effects on glycaemic status, HDL-cholesterol, GSH and blood pressure among women at risk for pre-eclampsia.
Uncertainties in the risk assessment of three mycotoxins: aflatoxin, ochratoxin, and zearalenone.

The risk assessment of mycotoxins is made up of two major components: an exposure assessment and a hazard assessment. There are many uncertainties in both of these components. This paper will briefly discuss the various aspects of the risk assessment process as it applies to mycotoxins and will then focus mainly on some of the uncertainties in the hazard assessment component of several carcinogenic mycotoxins. To arrive at an estimated "safe dose" (end point of the hazard assessment), we have previously used two major approaches: the no observed effect level (NOEL) divided by a safety factor approach and a mathematical (robust linear) extrapolation to a "virtual safe dose. " Both of these approaches use only points from the no observed effect region of the dose-response curve and ignore valuable data from the response region. It is proposed to use the dose at which 50% of the animals would have developed tumors (the TD50) divided by a large safety factor of 50,000 as an additional estimate of "safe dose". For many studies, the TD50 lies within the observed response region of the dose-response curve and may have more validity. It is also suggested in certain cases that some of the uncertainties regarding the NOEL can be reduced if one uses a statistically derived no effect level (NEL).
Business Formation and Aggregate Investment

Abstract The paper proposes an intertemporal equilibrium model of vintage capital and monopolistic competition. Reflecting a tradeoff between the number and capacity of new machines, investment may be extensive or intensive. External gains from specialization and rationalization result in distorted investment decisions. The paper compares the effectiveness of a general investment tax credit with a start-up subsidy that shifts the direction of investment towards a more extensive form. An optimal policy of investment promotion is derived.
The combination of bortezomib with chemotherapy to treat relapsed/refractory acute lymphoblastic leukaemia of childhood

Achieving complete remission (CR) in childhood relapsed/refractory acute lymphoblastic leukaemia (ALL) is a difficult task. Bortezomib, a proteasome inhibitor, has in vitro activity against ALL blasts. A phase I‐II trial, reported by the Therapeutic Advances in Childhood Leukaemia and Lymphoma (TACL) consortium, demonstrated that bortezomib with chemotherapy has acceptable toxicity and remarkable activity in patients with relapsed ALL failing 2–3 previous regimens. We evaluated bortezomib in combination with chemotherapy in 30 and 7 children with B‐cell precursor (BCP) and T‐cell ALL, respectively. Bortezomib (1·3 mg/m2/dose) was administered intravenously on days 1, 4, 8, and 11. Chemotherapy agents were the same as those used in the TACL trial, consisting of dexamethasone, doxorubicin, vincristine and pegylated asparaginase. Three patients (8·1%) died due to infections. Twenty‐seven patients (72·9%) achieved CR or CR with incomplete platelet recovery (CRp). Fourteen had minimal residual disease (MRD) lower than 0·1%. Twenty‐two of 30 BCP‐ALL patients (73·3%) and 5/7 patients (71%) with T‐cell ALL achieved CR/CRp. The 2‐year overall survival (OS) is 31·3%; CR/CRp patients with an MRD response had a remarkable 2‐year OS of 68·4%. These data confirm that the combination of bortezomib with chemotherapy is a suitable/effective option for childhood relapsed/refractory ALL.
Establishing the "Biological Relevance" of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels.

Phthalate esters (PEs) constitute a large class of compounds that are used for many consumer product applications. Many of the C2-C7 di-ortho PEs reduce fetal testicular hormone and gene expression levels in rats resulting in adverse effects seen later in life but it appears that relatively large reductions in fetal testosterone (T) levels and testis gene expression may be required to adversely affect reproductive development (Hannas, B. R., Lambright, C. S., Furr, J., Evans, N., Foster, P. M., Gray, E. L., and Wilson, V. S. (2012). Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency. Toxicol. Sci. 125, 544-557). The objectives of this study were (1) to model the relationships between changes in fetal male rat plasma testosterone (PT), T levels in the testis (TT), T production (PROD), and testis gene expression with the reproductive malformation rates, and (2) to quantify the "biologically relevant reductions" (BRRs) in fetal T necessary to induce adverse effects in the offspring. In the fetal experiment, Harlan Sprague-Dawley rats were dosed with dipentyl phthalate (DPeP) at 0, 11, 33, 100, and 300 mg/kg/day from gestational days (GD) 14-18 and fetal testicular T, PT levels, and T Prod and gene expression were assessed on GD 18. In the postnatal experiment, rats were dosed with DPeP from GD 8-18 and reproductive development was monitored through adulthood. The dose-response curves for TT levels (ED(50) = 53 mg/kg) and T PROD (ED(50) = 45 mg/kg) were similar, whereas PT was reduced at ED50 = 19 mg/kg. When the reductions in TPROD and Insl3 mRNA were compared with the postnatal effects of in utero DPeP, dose-related reproductive alterations were noted when T PROD and Insl3 mRNA were reduced by >45% and 42%, respectively. The determination of BRR levels may enable risk assessors to utilize fetal endocrine data to help establish points of departure for quantitative risk assessments.
Glucokinase diabetes in 103 families from a country‐based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations

Pruhova S, Dusatkova P, Sumnik Z, Kolouskova S, Pedersen O, Hansen T, Cinek O, Lebl J. Glucokinase diabetes in 103 families from a country‐based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations.
Myocardial Deformation Imaging: Current Status and Future Directions

Myocardial deformation imaging is a novel echocardiographic method for assessment of global and regional myocardial function. As this technology has evolved, it has been applied to an increasing number of research questions, and the number of publications incorporating deformation imaging has grown in parallel. Although not yet sufficiently vetted for routine clinical use, these methods offer the long-term potential for more complete, accurate, and reproducible assessment of myocardial function. Evaluation of contractile function with echocardiography has traditionally been limited to volume-based assessment of ejection fraction (EF) and assessment of regional wall motion or visual estimation of regional thickening. These methods have suffered from lack of reproducibility and standardization and are generally considered to be extremely sensitive to loading conditions. These limitations have led to an interest in techniques that provide more objective and reproducible measures of contractile function. During systole, the ventricular myocardium simultaneously shortens in the longitudinal and circumferential planes and thickens in the radial plane, with reciprocal changes in diastole (Figure). Deformation imaging, in the broadest sense, allows for more direct assessment of myocardial muscle shortening and lengthening throughout the cardiac cycle by assessing regional myocardial strain and strain rate. Strain is defined as the change in length of a segment of myocardium relative to its resting length and is expressed as a percentage; strain rate is the rate of this deformation. Longitudinal and circumferential shortening results in negative strain values, whereas radial thickening results in a positive strain value. Previously, assessment of myocardial strain could be performed with the use of sonomicrometry crystals, which can only be performed experimentally1 or with magnetic resonance imaging–based myocardial tagging,2,3 which is limited by relatively low temporal resolution and the limited availability and expense of cardiac magnetic resonance imaging. Extension of these techniques to echocardiography has allowed …
FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete Leptospira

The spirochete endoflagellum is a unique motility apparatus among bacteria. Despite its critical importance for pathogenesis, the full composition of the flagellum remains to be determined. We have recently reported that FcpA is a novel flagellar protein and a major component of the sheath of the filament of the spirochete Leptospira. By screening a library of random transposon mutants in the spirochete Leptospira biflexa, we found a motility-deficient mutant harboring a disruption in a hypothetical gene of unknown function. Here, we show that this gene encodes a surface component of the endoflagellar filament and is required for typical hook- and spiral-shaped ends of the cell body, coiled structure of the endoflagella, and high velocity phenotype. We therefore named the gene fcpB for flagellar-coiling protein B. fcpB is conserved in all members of the Leptospira genus, but not present in other organisms including other spirochetes. Complementation of the fcpB− mutant restored the wild-type morphology and motility phenotypes. Immunoblotting with anti-FcpA and anti-FcpB antisera and cryo-electron microscopy of the filament indicated that FcpB assembled onto the surface of the sheath of the filament and mostly located on the outer (convex) side of the coiled filament. We provide evidence that FcpB, together with FcpA, are Leptospira-specific novel components of the sheath of the filament, key determinants of the coiled and asymmetric structure of the endoflagella and are essential for high velocity. Defining the components of the endoflagella and their functions in these atypical bacteria should greatly enhance our understanding of the mechanisms by which these bacteria produce motility.
Why Join? Why Stay? Instrumentality, Beliefs, Satisfaction and Individual Decisions on Union Membership

To understand individuals' union membership choices it is necessary to examine decisions both to join and to leave (exit) unions, observed when employees are in jobs where unions are available and there is freedom of choice on union membership (‘open’ jobs). Using multivariate analysis of survey data, it was found that sympathy towards unions was the most powerful influence upon union joining, but had little impact on union exit, which was more a function of the perceived instrumentality of membership. Employee perceptions on union in-fighting and cooperation with management influenced union membership, as did the outcome of involvement in industrial disputes. Satisfaction with union delegates was a key influence on attitudes and membership. Employee trust of management only influenced exit behaviour through its interaction with satisfaction with union delegates. Job satisfaction had a complex relationship with union membership that is disguised in aggregated studies.
Gender pay equity, wage fixation and industrial relations reform in Australia : one step forward and two steps backwards?

Purpose – The purpose of this paper is to discuss the impact on the new federal wage fixing system on gender pay equity in Australia.Design/methodology/approach – The article is divided into four parts. The first section briefly examines the policy approach to the issue of gender pay equity in other Anglophone counties and the history of pay (in)equity under the Australian tribunal based industrial relations system. The second section overviews the recent developments at the State level in Australia focused on gender pay equity. The third section discusses recent cases in State wage fixing systems in Australia designed to remedy the gender based undervaluation of children's services employees. The fourth and final section discusses the implications of the new “national” workplace relations laws in the context of gender pay equity in Australia.Findings – The capacity of State tribunals to continue to apply gender free wage determinations is under threat because of the federal government's 2006 “reforms” to.
On the Impact of Regulating Commissions: Evidence from the Indian Mutual Funds Market

Commissions-motivated agents have historically helped the development of many markets, but research suggests brokers motivated by commissions sometimes steer consumers towards inappropriate products. This issue is particularly important in household financial markets where consumers may be unable to evaluate products on their own. While reforms attempting to limit commission payments have been undertaken worldwide, little research has evaluated the impact of these reforms. We study a major Indian investor protection reform that attempted to reduce commissions tied to mutual fund sales by banning the distribution fees that mutual funds had previously earmarked for commissions. We analyze the policy impact by comparing funds charging high versus low distribution fees pre-reform and find no evidence that the reform itself reduced fund flows. We argue that the most plausible explanation is that the Indian asset management industry maintained substantial commissions to brokers through other revenue sources apart from the banned distribution fees.