Miracle-dz/UniFAR-FTUs huggingface dataset:
Current induced noise in CPP spin valves

In this paper, an experimental investigation of current-induced noise in current perpendicular-to-plane spin-valve heads is reported. It is found that the sense current yields excitations of coherent spin waves as well as substantial 1/f-like noise when current exceeds a critical value. The noise is magnetic in nature. The criticality and current directional dependence of the noise excitation clearly show that the spin transfer is the cause.
Fetal brain function in response to maternal alcohol consumption: early evidence of damage.

BACKGROUND Studies of the adverse neurobehavioral effects of maternal alcohol consumption on the fetus have been largely confined to the postnatal period, after exposure to alcohol has finished. This study explored the brain function of the fetus, at the time of exposure to alcohol, to examine its effect on information processing and stability of performance. METHODS Five groups of fetuses, defined by maternal alcohol consumption patterns, were examined: control (no alcohol); moderate (5 to 10 units/wk either drunk evenly across the week or as a binge, in 2 to 3 days); heavy (20+ units/wk drunk evenly or as a binge). Fetal habituation performance was examined on 3 occasions, separated by 7 days, beginning at 35 weeks of gestation. The number of trials required to habituate on each test session and the difference in performance across test sessions were recorded. RESULTS Fetuses exposed to heavy binge drinking required significantly more trials to habituate and exhibited a greater variability in performance across all test sessions than the other groups. Maternal drinking, either heavily but evenly or moderately as a binge, resulted in poorer habituation, and moderate binge drinking resulted in greater variability compared with no, or even, drinking. CONCLUSIONS Decreased information processing, reflected by poorer habituation, and increased variability in performance may reflect the initial manifestations of structural damage caused by alcohol to the brain. These results will lead to a greater understanding of the effects of alcohol on the fetus's brain, enable the antenatal identification of fetal alcohol spectrum disorders, and lead to the early implementation of better management strategies.
Chronic hepatitis E virus infection is specifically associated with an interferon-related transcriptional program.

BACKGROUND Hepatitis E virus (HEV) is a new causative agent of chronic hepatitis in solid organ transplant recipients. Clinical studies suggest that the occurrence and persistence of chronic HEV infection are related to the immunological status of patients. METHODS We used whole-genome microarray and quantitative reverse transcription polymerase chain reaction (qRT-PCR) to compare the transcriptional profiles of whole blood from 8 kidney transplant recipients with chronic HEV infection and 8 matched kidney transplant recipients without HEV infection. RESULTS We found that 30 genes in HEV-infected patients were upregulated, compared with those in control patients, as determined by microarray analysis. In contrast, no genes were downregulated. The 30 upregulated genes included 25 interferon-stimulated genes. Increased expression of the genes that encode IFIT1, IFI44L, RSAD2, EPSTI1, and ISG15 was confirmed by qRT-PCR. Interestingly, the expression levels of these genes were associated with the persistence of HEV infection. CONCLUSIONS Increased expression of interferon-stimulated genes may favor the persistence of an HEV infection. Whether the expression of interferon-stimulated genes is a marker of ongoing viremia or independent prognostic marker of HEV clearance needs further investigations. CLINICAL TRIALS REGISTRATION NCT01090232.
A nafion coated capacitive humidity sensor on a flexible PET substrate

This paper reports a simple and low-cost technique for fabricating low-power capacitive humidity sensors without the use of a cleanroom environment. A maskless laser engraving system was utilized to fabricate two different gold electrode structures, interdigitated electrodes and Hilbert's fifth-order fractal. The capacitive structures were implemented on a flexible PET substrate. The usage of Nafion, a well-known polymer for its hydrophilic properties as a sensing film, was attempted on the PET and outperformed the current efforts in flexible substrates. Its humidity sensing properties were evaluated in an automated gas setup with a relative humidity (RH %) ranging from 15% to 95 %.
Results of a telehealth-enabled chronic care management service to support people with long-term conditions at home

Both congestive heart failure and chronic obstructive pulmonary disease are more common among Māori than non-Māori people, and the cultural acceptability of home-based remote monitoring technology has not been tested. We conducted a 12-month pilot trial of home telemonitoring. Patients were randomly assigned to the control and intervention groups. Patients in the control group showed no clear differences in quality of life at the end of the trial. The telehealth group showed a consistent trend towards improved quality of life on several instruments, including the SF-36, the St George Respiratory Questionnaire and the K10 questionnaire; the improvement in the latter was significant. Hospitalizations were reduced in both the control (−19%) and telehealth group (−25%). Patient interviews indicated that the technology was acceptable to most patients and their families, including the Māori. The results from the pilot trial suggest that wider implementation with a cost benefit evaluation could be worthwhile.
Ion channels and transporters in tumour cell migration and invasion

Cell migration is a central component of the metastatic cascade requiring a concerted action of ion channels and transporters (migration-associated transportome), cytoskeletal elements and signalling cascades. Ion transport proteins and aquaporins contribute to tumour cell migration and invasion among other things by inducing local volume changes and/or by modulating Ca2+ and H+ signalling. Targeting cell migration therapeutically bears great clinical potential, because it is a prerequisite for metastasis. Ion transport proteins appear to be attractive candidate target proteins for this purpose because they are easily accessible as membrane proteins and often overexpressed or activated in cancer. Importantly, a number of clinically widely used drugs are available whose anticipated efficacy as anti-tumour drugs, however, has now only begun to be evaluated.
The Disturbed Violent Offender.@@@Murder: An Analysis of Its Forms, Conditions and Causes.

A unique study providing evidence that murder is predictable and the exceptionally high murder rate in the United States is reduceable. Part I examines 50 case histories and an analysis of 912 homicides from an original study made in Erie County (Buffalo), New York. Part II discusses multicide, serial killers, and mass murderers. Part III covers assassinations and executions and a final part presents conclusions.
Treatment of thoracolumbar burst fractures: short-segment pedicle instrumentation versus kyphoplasty.

UNLABELLED The management of amyelic thoracolumbar burst fractures remains controversial. In this study, we compared the clinical efficacy of percutaneous kyphoplasty (PKP) and short-segment pedicle instrumentation (SSPI). Twenty-three patients were treated with PKP, and 25 patients with SSPI. They all presented with Type A3 amyelic thoracolumbar fractures. Clinical outcomes were evaluated by a Visual Analog Scale (VAS) and Oswestry Disability Index (ODI) preoperatively, postoperatively, and at two years follow-up. Radiographic data including the anterior and posterior vertebral body height, kyphotic angle, as well as spinal canal compromise was also evaluated. The patients in both groups were similar regarding age, bone mineral density (BMD), follow-up period, severity of the deformity and fracture. Blood loss, operation time, and bed-rest time were less in the PKP group. VAS, ODI score improved more rapidly after surgery in the PKP group. No significant difference was found in VAS and ODI scores between the two groups at final follow-up (p > 0.05). Meanwhile, the height of anterior vertebrae (Ha), the height of posterior vertebrae (Hp) and the kyphosis angle showed significant improvement in each group (p < 0.05). The postoperative improvement in spinal canal compromise was not statistically significant in the PKP group (p > 0.05); there was a significant improvement in the SSPI group (p < 0.05). Moreover, these postoperative radiographic assessments showed significant differences between the two groups regarding the improvement of canal compromise (p < 0.05). At final follow-up, remodeling of spinal canal compromise was detected in both groups. CONCLUSION Both PKP and SSPI appeared as effective and reliable operative techniques for selected amyelic thoracolumbar fractures in the short-term. PKP had a significantly smaller blood loss and shorter bed-rest time, but SSPI provided a better reduction. Long-time studies should be conducted to support these clinical outcomes.
English language learners' writing behaviours during literacy-enriched block play

Despite the rising number of linguistically diverse students in countries where English is the primary medium of instruction in schools, there is a relative lack of research on how these students learn to write in English and respond to common classroom literacy practices. One practice found in early childhood classrooms is literacy-enriched play, but little research explores how young English language learners respond to this particular intervention. This exploratory study examines three linguistically diverse kindergarten students' use of writing materials in a literacy-enriched block centre in their classroom. Observational notes and writing samples produced by the students during block play were analyzed to determine the frequency and variety of their writing behaviours. The results indicated that all the students, regardless of language background, incorporated drawing and writing into their block play with similar frequency, although they sometimes used different writing strategies. These findings indicated that literacy-enriched centres can provide linguistically diverse students with meaningful opportunities to practice writing.
Bigrams of Syntactic Labels for Authorship Discrimination of Short Texts

We present a method for authorship discrimination that is based on the frequency of bigrams of syntactic labels that arise from partial parsing of the text. We show that this method, alone or combined with other classification features, achieves a high accuracy on discrimination of the work of Anne and Charlotte Bronte ¨, which is very difficult to do by traditional methods. Moreover, high accuracies are achieved even on fragments of text little more than 200 words long.
The Promise of Preventive Cancer Vaccines

Years of unsuccessful attempts at fighting established tumors with vaccines have taught us all that they are only able to truly impact patient survival when used in a preventive setting, as would normally be the case for traditional vaccines against infectious diseases. While true primary cancer prevention is still but a long-term goal, secondary and tertiary prevention are already in the clinic and providing encouraging results. A combination of immunopreventive cancer strategies and recently approved checkpoint inhibitors is a further promise of forthcoming successful cancer disease control, but prevention will require a considerable reduction of currently reported toxicities. These considerations summed with the increased understanding of tumor antigens allow space for an optimistic view of the future.
Graph-Based Residence Location Inference for Social Media Users

Location information in social media is becoming increasingly vital in applications such as election prediction, epidemic forecasting, and emergency detection. However, only a tiny proportion of users proactively share their residence locations (which can be used to approximate the locations of most user-generated content) in their profiles, and inferring the residence location of the remaining users is nontrivial. In this article, the authors propose a framework for residence location inference in social media by jointly considering social, visual, and textual information. They first propose a data-driven approach to explore the use of friendship locality, social proximity, and content proximity for geographically nearby users. Based on these observations, they then propose a location propagation algorithm to effectively infer residence location for social media users. They extensively evaluate the proposed method using a large-scale real dataset and achieve a 15 percent relative improvement over state-of-the-art approaches.
The transition of mature students to higher education: Challenging traditional concepts?

Abstract The Bologna Process, recently implemented in Portugal, has brought many changes to higher education institutions. One of these changes refers to a law that enables mature students (23 years and older) to gain special access to higher education, taking into account their professional experience and other biographical elements. The numbers of non-traditional students are therefore increasing in our country, making our academic population more diverse. We designed a research project to investigate the special circumstances of non-traditional students in our institutions and to provide recommendations that should improve their academic lives. In this article, we describe survey results, focus-group interviews and life histories and use them to understand the transition of mature students into higher education. Our results include interpretations of the factors that students view as barriers to their participation in higher education, the importance of peer support, and reflections on life histories that provide greater insight into the transitional process. Although several barriers were identified by mature students, there is also a positive impact from transition. It is clear that transition today is no longer punctual or linear either in time or space. We should therefore challenge traditional views of the transition concept, in which students are considered to be a problem to higher education institutions, because this diverts attention away from the responsibilities of those institutions towards facilitating change.
Accumulation of coronary artery disease risk factors over three years: data from an international inception cohort.

OBJECTIVE To examine the accumulation of risk factors over 3 years in a multicenter, international inception cohort of patients with systemic lupus erythematosus (SLE). METHODS The Systemic Lupus International Collaborating Clinics registry for atherosclerosis comprises 27 centers from 11 countries. An inception cohort of 935 patients with SLE was assembled, according to a standardized protocol, from 2000 to 2006 to study risk factors for atherosclerosis. Both classic and other coronary artery disease (CAD) risk factors were collected at entry and through 3 years of followup. Therapy was documented over the 3 years. The Framingham 10-year risk factor profile was calculated for each patient at year 1 and year 3. RESULTS A total of 278 patients from the inception cohort were followed for 3 years and constituted the population for this study. At enrollment a substantial number of patients already demonstrated several risk factors for CAD, both classic and other. All risk factors increased from enrollment over the 3 years of followup. Treatment of hypertension and hypercholesterolemia also increased over 3 years, but less so for hypercholesterolemia. The Framingham 10-year CAD risk profile was higher in men than in women both at entry and at 3 years, and remained unchanged over the 3 years. Corticosteroid use increased only slightly over 3 years, but use of antimalarials and immunosuppressive agents increased to a greater extent. CONCLUSION Patients with SLE should be monitored for CAD risk factors from the time of diagnosis and appropriate treatment should be instituted early.
Intrinsic Distortion of a Fully Differential BD-Modulated Class-D Amplifier With Analog Feedback

This paper presents a mathematical analysis of a fully differential BD-modulated Class-D amplifier with analog feedback, i.e., one having a bridge-tied-load output configuration with negative feedback and ternary PWM signal. Notwithstanding the highly nonlinear nature of the amplifier's operation, an extremely accurate closed-form expression for the audible output signal is derived and verified based on computer simulations. This expression demonstrates that there exist larger high-order intrinsic distortions (e.g., 5th-order harmonic distortion and intermodulation distortion) for BD-modulation, compared to that for AD-modulation (binary PWM signal). Furthermore, the 3rd-order harmonic distortion has a roughly parabolic response as a function of the magnitude of the input signal and reaches its peak when the modulation index of the input signal is around 0.7. Overall, the BD-modulated Class-D amplifier has a larger intrinsic distortion for small input signal but a smaller intrinsic distortion for large input signal, compared to AD-modulated designs.
The Effects of Comorbidity and Other Factors on Medical Versus Chiropractic Care for Back Problems

Study Design. This study is a cross‐sectional analysis of adults in the United States who reported at least one back‐related visit to a health care professional during a 2‐week reference period. Objectives. To estimate and compare the effects of comorbidity and other factors on self‐reported use of medical and chiropractic care for back problems in the United States. Summary of Background Data. Although back pain is the second most frequent primary symptom reported by patients seeking medical care and the most frequent primary symptom among chiropractic patients, there is a dearth of research on the predictors of chiropractic and medical care among back pain patients. Methods. Data from the 1989 National Health Interview Survey were used to perform a cross‐sectional analysis of adults who sought care for a back‐related condition. The primary predictor variables included comorbidity and associated disability, sociodemographic variables, and back‐problem‐related variables. Weighted logistic regression modeling was performed to estimate odds ratios adjusted for the effects of covariates. Results. Of the 4790 adults with reported back problems, 931 sought health care for their back condition during the 2‐week reference period. Adults with disabling comorbidities and back‐related restricted‐activity days were relatively less likely to use chiropractic care than primary medical care. Those who were male, high‐school educated, single, employed, and with more than nine doctor visits during the previous 12 months were relatively more likely to use chiropractic care than primary medical care. Conclusions. The presence of comorbidity‐related or back‐related disability, as well as other factors, affect the type of care sought for back conditions among adults in the United States.
Contact Tracing for Genital Chlamydia trachomatis in a Swedish County

Background: Contact tracing is one of the measures used to control genital Chlamydia trachomatis infections. Goal of this Study: To assess important variables of contact tracing in an everyday clinical setting. Study Design: Patients reported according to the STD Act were studied in a prospective, consecutive county‐based study. Results: A total of 149 patients had a mean of 2.2 partners. The social worker's patients reported significantly more partners than the physicians' patients. The median number of patients at the 26 involved institutions was 3. Treatment without a prior examination was prescribed to 4% of the partners; 95% of all notified partners were examined, and a majority of them were chlamydia‐infected. Conclusion: The requirements of the STD Act in Sweden are being followed reasonably well by health providers responsible for contact tracing, although an experienced social worker seems to get better results.
The effects of sport dance on brain connectivity and body intelligence

ABSTRACT Dancing is characterised by physical movement in accordance with rhythm perception. Twelve sport dancers and 12 age- and sex-matched young adults who had no dance experience (control group) were recruited. Body intelligence and brain activity were assessed in both groups using the Body Intelligence Scale (BIS) and resting state functional magnetic resonance imaging. BIS scores of dancers were higher than those of control subjects. The dancer group showed increased functional connectivity from the precentral gyrus to the right cingulate gyrus, right occipital fusiform gyrus, right inferior frontal gyrus, right medial frontal gyrus, left inferior frontal gyrus, right parietal postcentral gyrus, and right frontal lobe compared with control subjects. Sport dancers had increased body intelligence sensitivity compared with matched controls. In addition, the characteristics of dance, including physical movement in accordance with rhythm perception, might be associated with increased brain activity in the somatosensory and rhythm perception networks.
Successful Student Remediation Following Repeated Failures on the HESI Exam

A problem-based remediation plan was developed and implemented to improve the clinical reasoning abilities and standardized test taking abilities of 9 students following 2 failures of the HESI exam. Prior to implementation students were assessed for learning needs, presence of anxiety, and learning styles. After completing the remediation sessions, all students successfully passes the HESI Exam with scores of 99.99.
Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics

We previously demonstrated (Ookata et al., 1992, 1993) that the p34cdc2/cyclin B complex associates with microtubules in the mitotic spindle and premeiotic aster in starfish oocytes, and that microtubule- associated proteins (MAPs) might be responsible for this interaction. In this study, we have investigated the mechanism by which p34cdc2 kinase associates with the microtubule cytoskeleton in primate tissue culture cells whose major MAP is known to be MAP4. Double staining of primate cells with anti-cyclin B and anti-MAP4 antibodies demonstrated these two antigens were colocalized on microtubules and copartitioned following two treatments that altered MAP4 distribution. Detergent extraction before fixation removed cyclin B as well as MAP4 from the microtubules. Depolymerization of some of the cellular microtubules with nocodazole preferentially retained the microtubule localization of both cyclin B and MAP4. The association of p34cdc2/cyclin B kinase with microtubules was also shown biochemically to be mediated by MAP4. Cosedimentation of purified p34cdc2/cyclin B with purified microtubule proteins containing MAP4, but not with MAP-free microtubules, as well as binding of MAP4 to GST-cyclin B fusion proteins, demonstrated an interaction between cyclin B and MAP4. Using recombinant MAP4 fragments, we demonstrated that the Pro-rich C-terminal region of MAP4 is sufficient to mediate the cyclin B-MAP4 interaction. Since p34cdc2/cyclin B physically associated with MAP4, we examined the ability of the kinase complex to phosphorylate MAP4. Incubation of a ternary complex of p34cdc2, cyclin B, and the COOH-terminal domain of MAP4, PA4, with ATP resulted in intracomplex phosphorylation of PA4. Finally, we tested the effects of MAP4 phosphorylation on microtubule dynamics. Phosphorylation of MAP4 by p34cdc2 kinase did not prevent its binding to microtubules, but abolished its microtubule stabilizing activity. Thus, the cyclin B/MAP4 interaction we have described may be important in targeting the mitotic kinase to appropriate cytoskeletal substrates, for the regulation of spindle assembly and dynamics.