Miracle-dz/UniFAR-FTUs huggingface dataset:
Alterations in the Transcriptome of Soybean in Response to Enhanced Somatic Embryogenesis Promoted by Orthologs of AGAMOUS-Like15 and AGAMOUS-Like181[C][W][OPEN]

Transcriptome analysis indicates that ectopic expression of MADS domain transcription factors mimics the induction of somatic embryogenesis, providing a mechanism for its enhancement in culture. Somatic embryogenesis (SE) is a poorly understood process during which competent cells respond to inducing conditions, allowing the development of somatic embryos. It is important for the regeneration of transgenic plants, including for soybean (Glycine max). We report here that constitutive expression of soybean orthologs of the Arabidopsis (Arabidopsis thaliana) MADS box genes AGAMOUS-Like15 (GmAGL15) and GmAGL18 increased embryogenic competence of explants from these transgenic soybean plants. To understand how GmAGL15 promotes SE, expression studies were performed. Particular genes of interest involved in embryogenesis (ABSCISIC ACID-INSENSITIVE3 and FUSCA3) were found to be directly up-regulated by GmAGL15 by using a combination of quantitative reverse transcription-polymerase chain reaction and chromatin immunoprecipitation. To look more broadly at changes in gene expression in response to GmAGL15, we assessed the transcriptome using the Affymetrix Soybean Genome Array. Interestingly, the gene expression profile of 35Spro:GmAGL15 explants (0 d in culture) was found to resemble nontransgenic tissue that had been induced for SE by being placed on induction medium for 3 d, possibly explaining the more rapid SE development observed on 35Spro:GmAGL15 tissue. In particular, transcripts from genes related to the stress response showed increased transcript accumulation in explants from 35Spro:GmAGL15 tissue. These same genes also showed increased transcript accumulation in response to culturing nontransgenic soybean explants on the medium used to induce SE. Overexpression of GmAGL15 may enhance SE by making the tissue more competent to respond to 2,4-dichlorophenoxyacetic acid induction by differential regulation of genes such as those involved in the stress response, resulting in more rapid and prolific SE.
Context-aware interactive content adaptation

Automatic adaptation of content for mobile devices is a challenging problem because optimal adaptation often depends on the usage semantics of content, as well as the context of users (e.g., screen size of device being used, network connectivity, location, etc.). Usage-awaRe Interactive Content Adaptation (URICA) is an automatic technique that adapts content for mobile devices based on usage semantics. URICA allows a user who is unsatisfied with the system's current adaptation prediction to take control of the adaptation process and make changes until the content is suitably adapted for her purposes. The adaptation system learns from the user's modifications and adjusts its prediction for future accesses by other users. This paper shows that it is possible to exploit user interaction to learn how to adapt content based on context. We introduce Feedback-driven Context Selection (FCS), an automatic technique that leverages user interaction to identify the context that has the most impact on adaptation requirements. We added context-awareness to URICA so that it makes adaptation predictions for a user based only on the history of the community of users that share the context identified by FCS. The result is an automatic adaptation system that provides fine grain adaptations that reflect both the user's context and the content's usage semantics. This level of fine grain adaptation was previously available only in content that was customized manually. Experiments with two context-aware URICA prototypes show that FCS correctly identifies the contextual characteristics that impact adaptation requirements, and that grouping users into communities based on context improves the performance of the adaptation system by up to 79%.
Exploring Galaxy Evolution from Infrared Number Counts and Cosmic Infrared Background

Recently reported infrared (IR) galaxy number counts and cosmic infrared background (CIRB) all suggest that galaxies have experienced strong evolution sometime in their lifetime. We statistically estimate the galaxy evolution history from these data. We find that an order-of-magnitude increase of the far-infrared (FIR) luminosity at redshift z = 0.5–1.0 is necessary to reproduce the very high CIRB intensity at 140 μm reported by Hauser et al. (1998, AAA 070.161.559) and decreases to, even at most, a factor of 10 toward z ∼ 5, though many variants are allowed within these constraints. This evolution history also satisfies the constraints from the galaxy number counts obtained by IRAS, ISO and, roughly, SCUBA. The rapid evolution of the comoving IR luminosity density required from the CIRB well reproduces the very steep slope of galaxy number counts obtained by ISO. We also estimate the cosmic star formation history (SFH) from the obtained FIR luminosity density, considering the effect of the metal enrichment in galaxies. The derived SFH increases steeply with redshift in 0 0.75. This is consistent with the SFH estimated from the reported ultraviolet luminosity density. In addition, we present the performance of the Japanese ASTRO-F FIR galaxy survey. We show the expected number counts in the survey. We also evaluate how large a sky area is necessary to derive secure information of galaxy evolution up to z ∼ 1 from the survey, and find that at least 50–300 deg is required.
On modal components of the S4-logics

We consider the representation of each extension of the modal logic S4 as sum of two components. The rst component in such a representation is always included in Grzegorczyk logic and hence contains "modal resources" of the logic in question, while the second one uses essentially the resources of a corresponding intermediate logic. We prove some results towards the conjecture that every S4-logic has a representation with the least component of the rst kind.
Preventing disruptive behavior in early elementary schoolchildren: impact of a universal classroom-based preventive intervention

textabstractKnowledge about the development of children with disruptive behaviors, leading to disruptive disorders and related poor outcomes, guides prevention research in the development and evaluation of preventive interventions. The overview of effective interventions in this chapter showed that several effective intervention strategies are available to intervene in the development of disruptive behavior. Most of the development and evidence for effective prevention programs is based on studied in the USA. Consequently, these prevention programs are developed for use in the USA. It was therefore decided to develop a universal, classroom based preventive intervention for use in the Netherlands and determine the impact of this intervention. The main purpose of the present study was to examine the impact of Good Behavior Game (GBG; Barrish et aL, 1969; Dolan et aL, 1989) on the development of disruptive behaviors in young elementary schoolchildren in the Netherlands. The GBG a universal, classroom based preventive intervention program. In addition, the purpose was to study risk factors in the child, familial and parenting domain that predict whether children will or will not respond to the intervention. The secondary purpose of this study was to further our knowledge about developmental psychopathology. This was done by studying the characteristics of groups of children with similar patterns of disruptive behaviors and by studying developmental trajectories of children's aggression, the characteristics at onset as well as the consequences for following a specific developmental trajectory.
Craniofacial Morphology in Patients with Velocardiofacial Syndrome

Objective To compare cephalometric measurements of patients with and without velocardiofacial syndrome. Design Cross-sectional. Setting Public tertiary craniofacial center. Subjects Lateral cephalograms of 18 patients with velocardiofacial syndrome and 18 controls without morphofunctional alterations, matched for gender and age; all cephalograms were obtained before orthodontic intervention. Main Outcome Measures The cephalograms were manually traced and digitized for the achievement of linear and angular measurements. Results Individuals with velocardiofacial syndrome presented a reduced length of the skull base, retrusion of nasal bones, reduced posterior height of the maxilla, increased gonial angle, increased interincisal angle, greater lingual inclination of the mandibular incisors, reduced nasolabial angle, and reduced nasal depth compared with the control group. Conclusions Patients with velocardiofacial syndrome presented morphological differences compared with individuals without morphofunctional alterations, which might be considered in the evaluation of patients with suspected diagnosis of the syndrome, as well as for the establishment of treatment protocols adequate to their needs. The present findings did not support the hypothesis of differences in pharyngeal dimensions mentioned by other authors, suggesting that the velopharyngeal insufficiency in these patients may be caused by functional alterations rather than by anatomical differences.
COVERINGS OF SKEW-PRODUCTS AND CROSSED PRODUCTS BY COACTIONS

Abstract Consider a projective limit G of finite groups Gn. Fix a compatible family δn of coactions of the Gn on a C*-algebra A. From this data we obtain a coaction δ of G on A. We show that the coaction crossed product of A by δ is isomorphic to a direct limit of the coaction crossed products of A by the δn. If A=C*(Λ) for some k-graph Λ, and if the coactions δn correspond to skew-products of Λ, then we can say more. We prove that the coaction crossed product of C*(Λ) by δ may be realized as a full corner of the C*-algebra of a (k+1)-graph. We then explore connections with Yeend’s topological higher-rank graphs and their C*-algebras.
Sleep disturbances in patients with chronic pain: effectively managing opioid analgesia to improve outcomes

ABSTRACT Background: Many patients with chronic pain experience pain-related sleep disturbances, such as difficulty falling and staying asleep and less restful sleep. Evidence suggests that pain and sleep exist in a bidirectional relationship in which pain causes sleep disturbance and sleep disturbance intensifies pain. This association can impair a patient's daily function and decrease quality of life. Evidence suggests that patients with chronic pain can use opioid analgesics or other pain medications to control their pain and, in turn, improve some measures of sleep. This may include subjective sleep measures such as increased sleep time, and, as evidenced in recent studies, objective sleep measures such as sleep efficiency. Scope: The role of effective analgesia in the improvement of pain-related sleep disturbance is discussed herein, specifically the risks and benefits of opioid therapy for the treatment of patients with chronic pain and disturbed sleep. MEDLINE and PubMed searches were conducted to locate relevant studies dated from January 1975 to April 2008. English-only randomized controlled trials and nonrandomized studies were considered. Findings: Numerous studies support the benefits of effective analgesia with opioid therapy on sleep. Conclusion: Pain control achieved with pharmacotherapy, specifically opioid therapy, may help to improve sleep in patients for which opioid therapy is appropriate.
Time-Domain Design of UWB Vivaldi Antenna Array Using Multiobjective Particle Swarm Optimization

A method to obtain optimum tradeoffs (Pareto front) between sidelobe level (SLL) and beamwidth (BW) in time domain for ultrawideband (UWB) antenna arrays is presented. Multiobjective particle swarm optimization (MOPSO) is used to deal with these two conflicting objectives. In the optimization process, mutual coupling effects between elements are not considered. However, the multiple solutions obtained from MOPSO enable the designer to consider the mutual coupling effect as an additional constraint. Each element of the array is an antipodal Vivaldi antenna. The optimization template is applied for three different time-domain pattern descriptors. In comparison to arrays with the same number of elements reported in literature, the Pareto fronts obtained in this study provide lower BW and SLL. A four-element sample from resultant Pareto fronts was simulated by using CST Microwave Studio software. This array shows a 13.7-17.2 dBi gain over the whole frequency band from 3-11 GHz, 7.2° BW, and -12 dB SLL for energy pattern.
Nonlinear limits for single-crystal silicon microresonators

Nonlinear effects in single-crystal silicon microresonators are analyzed with the focus on mechanical nonlinearities. The bulk acoustic wave (BAW) resonators are shown to have orders-of-magnitude higher energy storage capability than flexural beam resonators. The bifurcation point for the silicon BAW resonators is measured and the maximum vibration amplitude is shown to approach the intrinsic material limit. The importance of nonlinearities in setting the limit for vibration energy storage is demonstrated in oscillator applications. The phase noise calculated for silicon microresonator-based oscillators is compared to the conventional macroscopic quartz-based oscillators, and it is shown that the higher energy density attainable with the silicon resonators can partially compensate for the small microresonator size. Scaling law for microresonator phase noise is developed.
An Experimental Study on Botulinum Toxin Type A for the Treatment of Excessive Secretion after Submandibular Gland Transplantation in Rabbits

Objectives. To investigate whether botulinum toxin type A (BTXA) could control excessive secretion after submandibular gland (SMG) transplantation in rabbits and its possible mechanisms. Methods. A new SMG transplantation model was established in rabbit. 30 successfully constructed models were randomly assigned to five groups including control group and four experimental groups. Secretion outputs were used to analyze the effect of BTXA injection on excessive secretion. Hematoxylin and eosin (HE) staining, transmission electron microscopy (TEM), Western blot, and immunofluorescence were performed to analyze its possible mechanisms. Results. After BTXA injection, a significant decrease of excessive secretion after SMG transplantation was found in 2 and 4 weeks groups, but no significant effect on 12 and 24 weeks groups. HE and TEM results showed that BTXA led to morphological and ultrastructural changes of acinar cells of transplanted SMG. Western blot results suggested that BTXA decreased the aquaporin-5 (AQP5) protein expression after BTXA injection for 2 and 4 weeks. Immunofluorescence results showed that AQP5 protein was mainly expressed in the cytoplasm after BTXA injection for 2 and 4 weeks, which might indicate that BTXA promoted AQP5 expression from the cell membrane to cytoplasm. Conclusion. BTXA could effectively control excessive secretion after SMG transplantation in rabbits.
Epidemiology of ankylosing spondylitis in Northwest Greece, 1983-2002.

OBJECTIVE To investigate the incidence and the prevalence of ankylosing spondylitis (AS) in a defined area of northwest Greece with a total population of about 500,000 inhabitants. METHODS AS cases were recorded from (i) in- and out-patients referred to the rheumatology clinics of the Ioannina university hospital and the Ioannina general hospital, and (ii) patients referred to private rheumatologists practising in the study area. An incident case was defined as any patient with AS, diagnosed during the period between 1 January 1983 and 31 December 2002 who were resident in the study area for at least 1 yr before the diagnosis. A prevalent case was defined as any patient with AS who was a resident of the study area on 31 December 2002. Diagnosis was based on the modified New York criteria for AS. Population data were based on the 1981, 1991 and 2001 National Censuses. RESULTS A total of 113 cases were diagnosed among the population of the area studied during the period 1983-2002. Men constituted a 4.65-fold higher number of patients than women, and had a significantly higher mean age at diagnosis. All patients presented bilateral sacroiliitis, 40 patients (35.9%) had peripheral joint involvement and 15 patients presented extra-articular manifestations (13.27%). HLA-B27 antigen was found in 80.5% of our patients. The age-adjusted mean annual incidence rate for the population aged > or =16 yr was 1.5 cases per 10(5) inhabitants [95% confidence interval (CI) 0.4-2.5], and the age-adjusted prevalence rate on 31 December 2002 was 29.5 cases per 10(5) inhabitants (95% CI 25.9-33.1). The incidence rates were higher in the age group 35-44 yr for men and in the age group 25-34 yr for women. CONCLUSION The incidence and prevalence of AS in the area studied were significantly lower than in other white populations and higher than in the Japanese population.
Listeria monocytogenes 10403S HtrA Is Necessary for Resistance to Cellular Stress and Virulence

ABSTRACT The HtrA serine protease has been shown to be essential for bacterial virulence and for survival after exposure to many types of environmental and cellular stresses. A Listeria monocytogenes 10403S htrA mutant was found to be sensitive to oxidative and puromycin-induced stress at high temperatures, showed a reduced ability to form biofilms, and was attenuated for virulence in mice.
Powered instrumentation and tissue effects in the nose and paranasal sinuses

Purpose of review The technologic cornerstones of endoscopic sinus surgery initially rested on the endoscope and CT scanning. In the mid-1990s, the advent of powered instrumentation, in particular the microdebrider, advanced the surgeon's ability to treat polypoid disease, sinus and nasal disease in a bleeding field, choanal atresia, antral choanal polyps, and inferior turbinate hypertrophy. This review evaluates both positive and negative tissue effects secondary to powered instrumentation. Recent findings Recent reports of deleterious outcomes with powered instrumentation require a reevaluation of the role of powered instrumentation and consideration of factors that lead to injury. The rapidity of injury makes the powered instrument especially dangerous in inexperienced hands. One third of participants in a recent survey were unaware that powered instruments could be involved in orbital injury and half were unaware that cranial injuries could be secondary to powered instrumentation. Summary Microdebriders will continue to advance the field of endoscopic surgery, providing clearer operative fields and causing less tissue trauma in experienced hands. However, the severity of complications, including the potential for rapidly aspirating orbital and cerebral contents when laminae are violated, must be appreciated and respected.
slr1923 of Synechocystis sp. PCC6803 Is Essential for Conversion of 3,8-Divinyl(proto)chlorophyll(ide) to 3-Monovinyl(proto)chlorophyll(ide)1

The deduced amino acid sequence of an slr1923 gene of Synechocystis sp. PCC6803 is homologous to archaean F420H2 dehydrogenase, which acts as a soluble subcomplex of reduced nicotinamide adenine dinucleotide dehydrogenase complex I. In this study, the gene was inactivated and characteristics of the mutant were analyzed. The mutant grew slower than the wild type under 100 μE m−2 s−1 but did not grow under high light intensity (300 μE m−2 s−1). The cellular content of chlorophyll was lower in the mutant, and the absorption spectrum showed a shift in the absorption peak of the Soret band to a longer wavelength by about 10 nm compared with the wild type. It was found, by high-performance liquid chromatography analysis, that the retention time of chlorophyll of the mutant is shorter than that of the wild type and that the peak wavelength of the Soret band was also shifted to a longer wavelength by 11 nm. Proton nuclear magnetic resonance analysis of the chlorophyll of the mutant revealed that the ethyl group of position 8 of ring B is replaced with a vinyl group. The spectrum indicates that the chlorophyll of the mutant is not a normal (3-vinyl)chlorophyll a but a 3,8-divinylchlorophyll a. These results strongly suggest that the Slr1923 protein is essential for the conversion from divinylchlorophyll(ide) to normal chlorophyll(ide). We thus designate this gene cvrA (a gene indispensable for cyanobacterial vinyl reductase).
MalwareTextDB: A Database for Annotated Malware Articles

Cybersecurity risks and malware threats are becoming increasingly dangerous and common. Despite the severity of the problem, there has been few NLP efforts focused on tackling cybersecurity. In this paper, we discuss the construction of a new database for annotated malware texts. An annotation framework is introduced based on the MAEC vocabulary for defining malware characteristics, along with a database consisting of 39 annotated APT reports with a total of 6,819 sentences. We also use the database to construct models that can potentially help cybersecurity researchers in their data collection and analytics efforts.
Root tip cell cycle synchronization and metaphase-chromosome isolation suitable for flow sorting in common wheat (Triticum aestivum L.).

An efficient procedure for cell-cycle synchronization in meristematic root tips was achieved in common wheat. Treatment parameters for synchronizing the cell cycle of root tip meristem cells, such as time-course and applied concentrations of various chemicals, were systematically tested and optimized by flow cytometric analysis of isolated nuclei. High mitotic indices (69.5% in the root tip meristematic area) were routinely obtained by treating germinating seeds with 1.25 mM hydroxyurea for 16 h, followed by incubation in a hydroxyurea-free solution for 2 h, and treatment with 1 μM trifluralin for 4 h. Uniform seed germination prior to treatment is very important for achieving consistently high metaphase indices in the root tips. Large numbers of metaphase chromosomes, suitable for flow cytometric analysis and sorting, were isolated from synchronized root tip cells. Flow sorted wheat chromosomes, via univariate and bivariate analysis, showed four major chromosome peaks. Each discrete peak may represent wheat chromosome types with similar DNA content. Bivariate flow karyotyping based on AT and GC content did not improve the separation of wheat chromosomes.