Miracle-dz/UniFAR-FTUs huggingface dataset:
Benign omental hemangiopericytoma presenting with hemoperitoneum: radiologic findings.

Crusco F, Chiodi M, Pugliese F, Mosca S, Fischer MJ, Lupattelli L(AQ1) emangiopericytoma is a rare perivascular tumor arising from the pericytes of Zimmerman and occurs primarily in adults and rarely in children, with no sex predilection. The most common sites of involvement are the lower extremities, head, neck, and retroperitoneum; less frequently, it affects the abdomen and pelvis. It usually appears as a well-circumscribed, solid hypervascular mass; necrosis and hemorrhage indicate a malignant form. In both benign and malignant cases, surgical removal is the primary treatment. To our knowledge, only 11 cases of omental hemangiopericytoma have been reported in the literature. We present a surgically confirmed case of omental bleeding hemangiopericytoma presenting with hemoperitoneum.
Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape

Epithelial cells acquire diverse shapes relating to their different functions. This is particularly relevant for the cochlear outer hair cells (OHCs), whose apical and basolateral shapes accommodate the functioning of these cells as mechano-electrical and electromechanical transducers, respectively. We uncovered a circumferential shape transition of the apical junctional complex (AJC) of OHCs, which occurs during the early postnatal period in the mouse, prior to hearing onset. Geometric analysis of the OHC apical circumference using immunostaining of the AJC protein ZO1 and Fourier-interpolated contour detection characterizes this transition as a switch from a rounded-hexagon to a non-convex circumference delineating two lateral lobes at the neural side of the cell, with a negative curvature in between. This shape tightly correlates with the ‘V’-configuration of the OHC hair bundle, the apical mechanosensitive organelle that converts sound-evoked vibrations into variations in cell membrane potential. The OHC apical circumference remodeling failed or was incomplete in all the mouse mutants affected in hair bundle morphogenesis that we tested. During the normal shape transition, myosin VIIa and myosin II (A and B isoforms) displayed polarized redistributions into and out of the developing lobes, respectively, while Shroom2 and F-actin transiently accumulated in the lobes. Defects in these redistributions were observed in the mutants, paralleling their apical circumference abnormalities. Our results point to a pivotal role for actomyosin cytoskeleton tensions in the reshaping of the OHC apical circumference. We propose that this remodeling contributes to optimize the mechanical coupling between the basal and apical poles of mature OHCs.
White-matter connectivity related to paliperidone treatment response in patients with schizophrenia

The objective of this study was to examine whether white-matter (WM) connectivity of patients with schizophrenia at early stage of treatment is related to treatment response after paliperidone extended-release (ER) treatment. Forty-one patients with schizophrenia and 17 age- and sex-matched healthy control subjects were included in this study. Brain magnetic resonance scans at 3 Tesla were conducted at early stage of treatment. Voxel-wise statistical analysis of the fractional anisotropy (FA) data was performed using Tract-Based Spatial Statistics. At baseline and eight weeks after paliperidone treatment, patients were assessed using the Positive and Negative Syndrome Scale, the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms. Among the patients with schizophrenia, the FA values of the corpus callosum, corona radiata, internal capsule, external capsule, superior longitudinal fasciculus and fronto-temporal WM regions showed significant negative correlations with scores of the treatment response. The current study suggests that the treatment response after paliperidone ER treatment may be associated with the fronto-temporo-limbic WM connectivity at early stage of treatment in patients with schizophrenia, and it could be used as a predictor of treatment response to paliperidone ER treatment after studies with large samples verify these results.
Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis

Two polyether ionophores, maduramicin and alborixin, were evaluated for anticryptosporidial activity in a severe combined immune deficient (SCID) mouse model of cryptosporidiosis. Groups of SCID mice were inoculated with 10(6) oocysts of bovine origin by oral gavage. Maduramicin or alborixin was administered beginning 4 weeks postinfection at 3 mg/kg of body weight per day. Maduramicin treatment resulted in a 96% reduction in fecal parasite load over the 3-week treatment period (P < 0.003). This reduction correlated with decreases in tissue parasite loads observed in histological sections of the small intestine (P < 0.000002) and the colon (P < 0.000006). A significant decrease in oocyst shedding was also observed after a 3-week treatment with alborixin (71% reduction, P < 0.01). Maduramicin was also evaluated in a relapsing model of cryptosporidiosis in which the infection was observed to recur after treatments were discontinued. Some toxicity, as demonstrated by weight loss, was observed with both maduramicin and alborixin. Both drugs exhibited significant anticryptosporidial activities with concomitant moderate toxicity. These polyether ionophores should be valuable as positive controls in compound evaluation studies and as lead compounds for chemical optimization (modification).
Gibberish Semantics: How Good is Russian Twitter in Word Semantic Similarity Task?

The most studied and most successful language models were developed and evaluated mainly for English and other close European languages, such as French, German, etc. It is important to study applicability of these models to other languages. The use of vector space models for Russian was recently studied for multiple corpora, such as Wikipedia, RuWac, lib.ru. These models were evaluated against word semantic similarity task. For our knowledge Twitter was not considered as a corpus for this task, with this work we fill the gap. Results for vectors trained on Twitter corpus are comparable in accuracy with other single-corpus trained models, although the best performance is currently achieved by combination of multiple corpora.
Socioeconomic Deprivation and Survival After Stroke: Findings From the Prospective South London Stroke Register of 1995 to 2011

Background and Purpose— Previous findings of the association between socioeconomic deprivation (SED) and survival after stroke are inconsistent. There is less investigation on long-term survival. We assessed the associations in a multi-ethnic population in England. Methods— We examined data from 4398 patients (3103 whites, 932 blacks, and 253 Asians/others) with first-ever stroke, collected by a population-based stroke register in South London from 1995 to 2011. SED was measured using the Carstairs index score—the higher score, the more deprived. It was analyzed in multivariate Cox regression models in relation to survival after stroke. Results— During 17-year follow-up 2754 patients died. The quartile data of Carstairs score showed no significant association of SED with survival in patients, except for black Caribbeans and Africans. Black patients with the fourth quartile SED had a multivariate adjusted hazard ratio of 1.76 (95% confidence interval, 1.06–2.94) for 3-month mortality and 1.54 (1.00–2.37) for 1-year mortality. After adjustment for acute stroke care provisions, these were no longer significant. However, the sextile data of Carstairs score showed a consistent association of SED with survival after stroke; all patients with the sixth sextile had a fully adjusted hazard ratio of 1.23 (1.05–1.44) for 3-month mortality and 1.13 (1.01–1.25) for 17-year mortality. Conclusions— There is a weak but significant association of SED with reduced survival after stroke in England. SED in blacks may have a stronger impact on short-term survival when compared with white patients. Further efforts are required to achieve equality in survival among patients with stroke of different socioeconomic groups.
Iron oxidation state in impact glass from the K/T boundary at Beloc, Haiti, by high‐resolution XANES spectroscopy

Abstract— We examined the local iron environment in nine impact glasses from the Cretaceous‐Tertiary (K/T) boundary section at Beloc, Haiti, which formed as the result of impact melting during the Chicxulub impact event. The samples have been analyzed by Fe K‐edge high‐resolution X‐ray absorption near edge structure (XANES) spectroscopy to obtain data on both the Fe oxidation state and the coordination number. The pre‐edge peak of our high‐resolution XANES spectra display noticeable variations indicative of significant changes in the Fe oxidation state spanning a wide range from about 20 to 75 mol% trivalent Fe. All data plot along the same trend, falling between two mixing lines joining a point calculated as the mean of a group of tektites studied so far (consisting of four‐ and five‐coordinated Fe2+) to [4]Fe3+ and [5]Fe3+, respectively. Thus, the XANES spectra can be interpreted as a mixture of [4]Fe2+, [5]Fe2+, [4]Fe3+, and [5]Fe3+. There is no evidence for six‐fold coordinated Fe; however, its presence in small amounts cannot be excluded from XANES data alone. Our observations can be explained by two possible scenarios: either these impact glasses formed under very reducing conditions and, because of their small size, were easily oxidized in air while still molten, or they formed under a variety of different oxygen fugacities resulting in different Fe oxidation states. In the first case, the oxidation state and coordination number would imply similar formation conditions as splash‐form tektites, followed by progressive oxidation.
Comparison of Global Navigation Satellite System Devices on Speed Tracking in Road (Tran)SPORT Applications

Global Naavigation Satellite Systems (GNSS) are, in addition to being most widely used vehicle navigation method, becoming popular in sport-related tests. There is a lack of knowledge regarding tracking speed using GNSS, therefore the aims of this study were to examine under dynamic conditions: (1) how accurate technologically different GNSS measure speed and (2) how large is latency in speed measurements in real time applications. Five GNSSs were tested. They were fixed to a car's roof-rack: a smart phone, a wrist watch, a handheld device, a professional system for testing vehicles and a high-end Real Time Kinematics (RTK) GNSS. The speed data were recorded and analyzed during rapid acceleration and deceleration as well as at steady speed. The study produced four main findings. Higher frequency and high quality GNSS receivers track speed at least at comparable accuracy to a vehicle speedometer. All GNSS systems measured maximum speed and movement at a constant speed well. Acceleration and deceleration have different level of error at different speeds. Low cost GNSS receivers operating at 1 Hz sampling rate had high latency (up to 2.16 s) and are not appropriate for tracking speed in real time, especially during dynamic movements.
Prejudice, stereotyping and discrimination: Theoretical and empirical overview

This chapter has two main objectives: to review influential ideas and findings in the literature and to outline the organization and content of the volume. The first part of the chapter lays a conceptual and empirical foundation for other chapters in the volume. Specifically, the chapter defines and distinguishes the key concepts of prejudice, stereotypes, and discrimination, highlighting how bias can occur at individual, institutional, and cultural levels. We also review different theoretical perspectives on these phenomena, including individual differences, social cognition, functional relations between groups, and identity concerns. We offer a broad overview of the field, charting how this area has developed over previous decades and identify emerging trends and future directions. The second part of the chapter focuses specifically on the coverage of the area in the present volume. It explains the organization of the book and presents a brief synopsis of the chapters in the volume. Throughout psychology’s history, researchers have evinced strong interest in understanding prejudice, stereotyping, and discrimination (Brewer & Brown, 1998; Dovidio, 2001; Duckitt, 1992; Fiske, 1998), aswell as the phenomenon of intergroup bias more generally (Hewstone, Rubin, & Willis, 2002). Intergroup bias generally refers to the systematic tendency to evaluate one’s own membership group (the ingroup) or its members more favorably than a non-membership group (the outgroup) or its members. These topics have a long history in the disciplines of anthropology and sociology (e.g., Sumner, 1906). However, social psychologists, building on the solid foundations of Gordon Allport’s (1954) masterly volume, The Nature of Prejudice, have developed a systematic and more nuanced analysis of bias and its associated phenomena. Interest in prejudice, stereotyping, and discrimination is currently shared by allied disciplines such as sociology and political science, and emerging disciplines such as neuroscience. The practical implications of this 4 OVERVIEW OF THE TOPIC large body of research are widely recognized in the law (Baldus, Woodworth, & Pulaski, 1990; Vidmar, 2003), medicine (Institute of Medicine, 2003), business (e.g., Brief, Dietz, Cohen, et al., 2000), the media, and education (e.g., Ben-Ari & Rich, 1997; Hagendoorn &
Questions: Formal, Functional and Interactional Perspectives

1. Introduction: questions are what they do Jan P. de Ruiter Part I. Questions: Interplay between Form and Function: 2. Interrogative intimations: on a possible social economics of interrogatives Stephen C. Levinson 3. Structures and questions in decision-making dialogues Jerry R. Hobbs 4. Mobilising response in interaction: a compositional view of questions Tanya Stivers and Frederico Rossano 5. Wordless questions, wordless answers Herbert H. Clark Part II. The Structure and Prosody of Questions: 6. Formal features of questions Jerry Sadock 7. Some truths and untruths about final intonation in conversational questions Elizabeth Couper-Kuhlen 8. Shaping the intonation of WH-questions: information structure and beyond Aoju Chen Part III. Questions and Stance: 9. Beyond answers: questions and children's learning Stanka A. Fitneva 10. Navigating epistemic landscapes: acquiescence, agency and resistance in responses to polar questions John Heritage and Geoffrey Raymond 11. Epistemic dimensions of polar questions: sentence-final particles in comparative perspective N. J. Enfield, Penelope Brown and Jan P. de Ruiter 12. Multi-functionality of interrogatives: asking reasons for and wondering about an action as overdone Mia Halonen and Marja-Leena Sorjonen.
Neuroscience and Biobehavioral Reviews Developmental pathways to autism: A review of prospective studies of infants at risk (cid:2)

Autism Spectrum Disorders (ASDs) are neurodevelopmental disorders characterized by impairments in social interaction and communication, and the presence of restrictive and repetitive behaviors. Symptoms of ASD likely emerge from a complex interaction between pre-existing neurodevelopmental vulnerabil- ities and the child’s environment, modiﬁed by compensatory skills and protective factors. Prospective studies of infants at high familial risk for ASD (who have an older sibling with a diagnosis) are beginning to characterize these developmental pathways to the emergence of clinical symptoms. Here, we review the range of behavioral and neurocognitive markers for later ASD that have been identiﬁed in high-risk infants in the ﬁrst years of life. We discuss theoretical implications of emerging patterns, and identify key directions for future work, including potential resolutions to several methodological challenges for the ﬁeld. Mapping how ASD unfolds from birth is critical to our understanding of the developmental mechanisms underlying this disorder. A more nuanced understanding of developmental pathways to ASD will help us not only to identify children who need early intervention, but also to improve the range of interventions available to them.
An adaptive normalization based constrained handling methodology with hybrid bi-objective and penalty function approach

A hybrid adaptive normalization based constraint handling approach is proposed in the present study. In most constrained optimization problems, constraints may be of different scale. Normalization of constraints is crucial for the efficient performance of a constraint handling algorithm. A growing number of researchers have proposed different strategies using bi-objective methodologies. Classical penalty function approach is another common method among both evolutionary and classical optimization research communities due to its simplicity and ease of implementation. In the present study, we propose a hybrid approach of both bi-objective method and the penalty function approach where constraints are normalized adaptively during the optimization process. The proposed bi-objective evolutionary method estimates the penalty parameter and the starting solution needed for the penalty function approach. We test and compare our algorithm on seven mathematical test problems and two engineering design problems taken from the literature. We compare our obtained results with our previous studies in terms of function evaluations and solution accuracy. The obtained optima are also compared with those of other standard algorithms. In many cases, our proposed methodology perform better than all algorithms considered in this study. Results are promising and motivate further application of the proposed adaptive normalization strategy.
The Relationship between the Third-Person Effect and the Acceptance of Fear-Based Road Safety Advertisements

Threat-based messages that appeal to the emotion of fear have been widely used in the social marketing of public health including road safety, AIDS/HIV awareness, and anti-smoking. However, despite their popularity and over five decades of research into the fear-persuasion relationship, an unequivocal answer regarding their effectiveness remains unachieved. More contemporary fear appeal research has begun exploring the extent other variables moderate this relationship. In this study, a phenomenon from the communication literature, known as the third-person effect (TPE), was examined to explore its association with the extent individuals reported intentions to adopt the recommendations (i.e., message acceptance) of two fear-based road safety advertisements. In contrast to the classic TPE hypothesis, this study found that individuals acknowledged more personal persuasiveness relative to other drivers in general. Moreover, reverse third-person differential perception scores were significantly associated with increased message acceptance. Additionally, two hierarchical regressions revealed that third-person differential perception scores contributed to the prediction of message acceptance for both the speeding and drink driving advertisement beyond the contribution of other variables previously established by the fear appeal literature as relating to message acceptance. This finding should be of particular significance for social marketers given that reverse third-person perceptions may act to predispose an individual to adopting the recommendations of a health message.
Differential Effects of an Angiotensin II Analogue on Pressor and Adrenal Receptors in the Rabbit

The 1-sarcosine-8-alanine analogue of angiotensin II (1-Sar-8-Ala-angiotensin II) was infused at 1 and 5 μg/kg min−1 into conscious rabbits on normal or sodium-deficient diets. Blood pressures during the control period were comparable in both groups; plasma renin activity, angiotensin II concentration, and aldosterone concentration were higher in the rabbits on the sodium-deficient diet than they were in the rabbits on the normal diet. The analogue caused a 6-mm Hg fall in mean arterial blood pressure in sodium-depleted rabbits. Plasma renin activity increased in both groups to eight to ten times the control values with the higher rate of infusion. Angiotensin II concentration paralleled plasma renin activity. Plasma aldosterone concentration increased after infusion of the analogue at 1 μg/kg min−1 to three to four times the control values but decreased from these high levels after an additional 90-minute infusion at 5 μg/kg min−1 to only one to two times the control values in both groups. Infusion of angiotensin II during the administration of the analogue caused a clear-cut increase in aldosterone concentration without a change in blood pressure. The persistence of elevated aldosterone levels during inhibitor blockade in the sodium-depleted rabbits does not prove that factors other than angiotensin participate in the aldosterone response to sodium deprivation. However, the data do indicate that 1-Sar-8-Ala-angiotensin II is a less effective antagonist of angiotensin II at the adrenal receptors than it is at the vascular smooth muscle receptors and suggest that the pressor and adrenal receptors differ.
First eigenvalue and maximum principle for fully nonlinear singular operators

In this paper we introduce the notion of first eigenvalue for fully nonlinear operators which are nonvariational but homogeneous. It is unnecessary to emphasize the importance of knowing the spectrum of a linear operator. When the operator is a uniformly elliptic operator of second order Lu = tr(A(x)D2u) associated with a Dirichlet problem in a bounded domain Ω the spectrum is a point spectrum bounded from below and the first eigenvalue λ is paramount. It is well known that λ is positive and it satisfies: • There exists a positive function φ satisfying { Lφ + λφ = 0 in Ω φ = 0 on ∂Ω.
Two Modes of Transcriptional Activation at Native Promoters by NF-κB p65

The NF-κB family of transcription factors is crucial for the expression of multiple genes involved in cell survival, proliferation, differentiation, and inflammation. The molecular basis by which NF-κB activates endogenous promoters is largely unknown, but it seems likely that it should include the means to tailor transcriptional output to match the wide functional range of its target genes. To dissect NF-κB–driven transcription at native promoters, we disrupted the interaction between NF-κB p65 and the Mediator complex. We found that expression of many endogenous NF-κB target genes depends on direct contact between p65 and Mediator, and that this occurs through the Trap-80 subunit and the TA1 and TA2 regions of p65. Unexpectedly, however, a subset of p65-dependent genes are transcribed normally even when the interaction of p65 with Mediator is abolished. Moreover, a mutant form of p65 lacking all transcription activation domains previously identified in vitro can still activate such promoters in vivo. We found that without p65, native NF-κB target promoters cannot be bound by secondary transcription factors. Artificial recruitment of a secondary transcription factor was able to restore transcription of an otherwise NF-κB–dependent target gene in the absence of p65, showing that the control of promoter occupancy constitutes a second, independent mode of transcriptional activation by p65. This mode enables a subset of promoters to utilize a wide choice of transcription factors, with the potential to regulate their expression accordingly, whilst remaining dependent for their activation on NF-κB.