Miracle-dz/UniFAR-FTUs huggingface dataset:
A 7.9 GHz Low-Power PMOS Colpitts VCO Using the Gate Inductive Feedback

A low-power PMOS Colpitts voltage controlled oscillator (VCO) topology using the technique of gate inductive feedback is demonstrated. The topology enhances the negative conductance and overcomes the start-up difficulty of the conventional Colpitts VCO. This enables the Colpitts VCO to be operated in low-power consumption. The fabricated VCO operates from 7.4 to 7.9 GHz with 7% tuning range, a power consumption of 4.9 mW, and a supply voltage of 1.5 V. The measured phase noise at 1 MHz offset is 108.3 dBc/Hz at 7.9 GHz.
Explanatory Value of General Self-Efficacy, Empathy and Emotional Intelligence in Overall Self-Esteem of Healthcare Professionals

ABSTRACT We analyze the explanatory value of individual variables such as self-efficacy, empathy and Emotional Intelligence for self-esteem in a sample of healthcare workers, and identicare the variables with the most explanatory value for overall self-esteem. A total of 386 healthcare professionals participated in this study (nursing, Certified Nursing Assistants, physicians and physiotherapists). In all the healthcare professionals, Mood, a dimension of Emotional Intelligence, and Self-Efficacy are predictors of self-esteem. This study showed that Self-Efficacy, Empathy and Emotional Intelligence have a significant positive relationship with Self-Esteem. The results have important practical implications for to promote the worker’s wellbeing and health.
The specificity of action knowledge in sensory and motor systems

Neuroimaging studies have found that sensorimotor systems are engaged when participants observe actions or comprehend action language. However, most of these studies have asked the binary question of whether action concepts are embodied or not, rather than whether sensory and motor areas of the brain contain graded amounts of information during putative action simulations. To address this question, we used repetition suppression (RS) functional magnetic resonance imaging to determine if functionally-localized motor movement and visual motion regions-of-interest (ROI) and two anatomical ROIs (inferior frontal gyrus, IFG; left posterior middle temporal gyrus, pMTG) were sensitive to changes in the exemplar (e.g., two different people “kicking”) or representational format (e.g., photograph or schematic drawing of someone “kicking”) within pairs of action images. We also investigated whether concrete versus more symbolic depictions of actions (i.e., photographs or schematic drawings) yielded different patterns of activation throughout the brain. We found that during a conceptual task, sensory and motor systems represent actions at different levels of specificity. While the visual motion ROI did not exhibit RS to different exemplars of the same action or to the same action depicted by different formats, the motor movement ROI did. These effects are consistent with “person-specific” action simulations: if the motor system is recruited for action understanding, it does so by activating one's own motor program for an action. We also observed significant repetition enhancement within the IFG ROI to different exemplars or formats of the same action, a result that may indicate additional cognitive processing on these trials. Finally, we found that the recruitment of posterior brain regions by action concepts depends on the format of the input: left lateral occipital cortex and right supramarginal gyrus responded more strongly to symbolic depictions of actions than concrete ones.
Antiglycolipid Antibodies in Motor Neuropathies a

ABSTRACT: In peripheral neuropathies with monoclonal gammopathy, mainly IgM, it appears clear from clinical, electrophysiological, and experimental data, that the target glycolipid or glycolipid epitope for the IgM is related to the type of neuropathy‐purely sensory, predominantly sensory, or uniquely motor. Investigations have focused on chronic peripheral neuropathies associated with polyclonal IgM reactivity to glycolipids. Although IgM anti‐GM1 antibodies are present in normal controls, there is a subgroup of motor neuropathies with high titer anti‐GM1 antibodies, mainly multifocal neuropathies with conduction blocks (MMNCB). Another subgroup of MMNCB may include IgM anti‐SGPG antibodies that do not cross‐react with MAG. The importance of the fine structure of the epitope has to be considered in view of the pathogenicity of the antibody. It may bear consequences on its binding properties on the neuronal surfaces and on its biological implications.
Low-perceived work ability, ageing and intention to leave nursing: a comparison among 10 European countries.

AIM This paper reports a study exploring nurses' perceived work ability and its associations with age and intention to leave nursing in a representative sample of registered nurses in 10 european countries. BACKGROUND Throughout Europe, there is now a substantial shortage of Registered Nurses and unless steps are taken to reverse this trend, numbers are likely to decline further. A study exploring nurses' perceived work ability will provide baseline evidence, which may lead to improved working conditions and increased nursing retention. METHODS A cross-sectional study design was employed. Questionnaire data were collected from 25,976 nurses in 10 member states of the European Union between October 2002 and June 2003. The response rate was 52.9% for the total investigation and varied between countries from 32.4% to 76.9%. Perceived work ability was assessed using the Work Ability Index. Intention to leave was measured by asking nurses how often they thought about leaving nursing. Data were examined using analysis of covariance and adjusted logistic regression. RESULTS In all 10 European countries, scores on the Work Ability Index were significantly lower (P < 0.01) among older nurses (>or=45 years). Work ability varied among countries and differences between younger and older nurses were more pronounced in some countries. In all countries, there was a significant association between low Work Ability Index and intention to leave nursing (odds ratios between 1.98 and 21.46), especially among younger nurses. The association between work ability and intention to leave was most marked for those items on the Work Ability Index which explored subjective rather than objective aspects of work ability. CONCLUSION Attempts to redress nursing shortages could include institutional policies to sustain work ability through better working conditions, improving quality of the working environment and finding suitable alternative nursing work for those no longer able to cope in their current post. These approaches should include nurses in all age categories.
A case study of likely wild-type cardiac transthyretin amyloidosis causing rapid deterioration

We present the case of an 88-year-old gentleman who presented to hospital septic with bilateral leg cellulitis, pulmonary oedema and hypotension. He had no history of heart disease but had had bilateral carpal tunnel releases. His condition deteriorated with refractory hypotension in spite of fluid filling, inotropic and vasopressor support. His echocardiogram showed an infiltrative cardiomyopathy with a speckled myocardium, severe concentric left and right ventricular increased wall thickness, diastolic dysfunction, biatrial dilatation and restrictive physiology in keeping with cardiac amyloidosis. He developed atrial fibrillation and worsening respiratory failure due to fluid overload and was intubated and ventilated but continued to decline and passed away. The degree of heart failure in the absence of ischaemia, the patient’s advanced age, echocardiographic findings and past history of carpal tunnel syndrome in a male are strongly indicative of a diagnosis of wild-type cardiac transthyretin amyloidosis. We discuss the key features and intensive care management of this disease.
Quantitative Analysis of Axonal Branch Dynamics in the Developing Nervous System

Branching is an important mechanism by which axons navigate to their targets during neural development. For instance, in the developing zebrafish retinotectal system, selective branching plays a critical role during both initial pathfinding and subsequent arborisation once the target zone has been reached. Here we show how quantitative methods can help extract new information from time-lapse imaging about the nature of the underlying branch dynamics. First, we introduce Dynamic Time Warping to this domain as a method for automatically matching branches between frames, replacing the effort required for manual matching. Second, we model branch dynamics as a birth-death process, i.e. a special case of a continuous-time Markov process. This reveals that the birth rate for branches from zebrafish retinotectal axons, as they navigate across the tectum, increased over time. We observed no significant change in the death rate for branches over this time period. However, blocking neuronal activity with TTX slightly increased the death rate, without a detectable change in the birth rate. Third, we show how the extraction of these rates allows computational simulations of branch dynamics whose statistics closely match the data. Together these results reveal new aspects of the biology of retinotectal pathfinding, and introduce computational techniques which are applicable to the study of axon branching more generally.
Patterns of spread of influenza A in Canada

Understanding spatial patterns of influenza transmission is important for designing control measures. We investigate spatial patterns of laboratory-confirmed influenza A across Canada from October 1999 to August 2012. A statistical analysis (generalized linear model) of the seasonal epidemics in this time period establishes a clear spatio-temporal pattern, with influenza emerging earlier in western provinces. Early emergence is also correlated with low temperature and low absolute humidity in the autumn. For the richer data from the 2009 pandemic, a mechanistic mathematical analysis, based on a transmission model, shows that both school terms and weather had important effects on pandemic influenza transmission.
Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil

Background The Kato-Katz (KK) stool smear is the standard test for the diagnosis of Schistosoma mansoni infection, but suffers from low sensitivity when infections intensities are moderate to low. Thus, misdiagnosed individuals remain untreated and contribute to the disease transmission, thereby forestalling public health efforts to move from a modality of disease control to one of elimination. As an alternative, the urine-based diagnosis of schistosomiasis mansoni via the circulating cathodic antigen immuno-chromatographic test (CCA-ICT) has been extensively evaluated in Africa with the conclusion that it may replace the KK test in areas where prevalences are moderate or high. Methods and Findings The objective was to measure the performance of the CCA-ICT in a sample study population composed of residents from non-endemic and endemic areas for schistosomiasis mansoni in two municipalities of Minas Gerais state, Brazil. Volunteers (130) were classified into three infection status groups based on duplicate Kato-Katz thick smears from one stool sample (2KK test): 41 negative individuals from non-endemic areas, 41 negative individuals from endemic areas and 48 infected individuals from endemic areas. Infection status was also determined by the CCA-ICT and infection exposure by antibody ELISA (enzyme-linked immunosorbent assay) to S. mansoni soluble egg antigen (SEA) and soluble (adult) worm antigen preparation (SWAP). Sensitivity and specificity were influenced by whether the trace score visually adjudicated in the CCA-ICT was characterized as positive or negative for S. mansoni infection. An analysis of a two-graph receiver operating characteristic was performed to change the cutoff point. When the trace score was interpreted as a positive rather than as a negative result, the specificity decreased from 97.6% to 78.0% whereas sensitivity increased from 68.7% to 85.4%. A significantly positive correlation between the CCA-ICT scores and egg counts was identified (r = 0.6252, p = 0.0001). However, the CCA-ICT misdiagnosed as negative 14.6% of 2KK positive individuals, predominantly those with light infections (fewer than 100 eggs/g feces). Considering 2KK as reference test, the discriminating power of the CCA-ICT (the area under the curve [AUC] = 0.817) was greater than the SEA-ELISA (AUC = 0.744) and SWAP-ELISA (AUC = 0.704). Conclusion Our data for the performance of the CCA-ICT in the Brazilian communities endemic for schistosomiasis mansoni support those from Africa, i.e., in areas with greater infection prevalence and intensities, the CCA-ICT may be useful as a tool to indicate community-based preventative chemotherapy without individual diagnosis. However, because of the Brazilian Ministry of Health’s recommendation for individual diagnosis in areas where prevalence is less than 15%, i.e., those areas in which infection intensities are likely to be lowest, the CCA-ICT lacks the sensitivity to be used as standalone diagnostic tool.
HIGHLIGHTS OF PRESCRIBING INFORMATION

LAMOTRIGINE tablets, USP, for oral use Initial U.S. Approval: 1994 WARNING: SERIOUS SKIN RASHES See full prescribing information for complete boxed warning. • Cases of life-threatening serious rashes, including StevensJohnson syndrome and toxic epidermal necrolysis, and/or rashrelated death have been caused by lamotrigine. The rate of serious rash is greater in pediatric patients than in adults. Additional factors that may increase the risk of rash include: • coadministration with valproate. • exceeding recommended initial dose of lamotrigine. • exceeding recommended dose escalation for lamotrigine. (5.1) • Benign rashes are also caused by lamotrigine; however, it is not possible to predict which rashes will prove to be serious or life threatening. Lamotrigine should be discontinued at the first sign of rash, unless the rash is clearly not drug related. (5.1)
Seasonal variations of cancer incidence and prognosis

The overall death rates are highest in the winter season in many countries at high latitudes. In some, but not all countries, this is also true for more specific diseases such as cancer, cardiovascular diseases and influenza. For internal cancers we find no consistent, significant seasonal variation, neither of incidence nor of death rates. On the other hand, we find a significant seasonal variation of cancer prognosis with season of diagnosis in Norway. Best prognosis is found for summer and autumn diagnosis; i.e. for the seasons of the best status of vitamin D in the population. There were no corresponding seasonal variations, neither of the rates of diagnosis, nor of the rates of death which could explain the variations of prognosis. The most likely reason for this variation is that the vitamin D status in Norway is significantly better in summer and autumn than in winter and spring. Earlier, seasonal variations have been explained by circannual variations of certain hormones, but the data are not consistent.
On effective speaker verification based on subword model

This paper concerns an effective text-dependent speaker verification method to increase the performance of speaker verification. While various speaker verification methods have already been developed, their effectiveness has not yet been formally proven in terms of achieving acceptable performance level. This paper proposes a weighted likelihood procedure along with a confidence measure based on subword-based text-dependent speaker verification. Our aim is to remedy the low performance problem in speaker verification by exploring a means to strengthen the verification likelihood via subword-based hypothesis criteria and weighted likelihood method. Experimental results show that the proposed speaker verification method outperforms that of the speaker verification scheme without using the proposed decision by a factor of up to 1.6 times. From these results, the proposed speaker verification method is shown to be very effective and to achieve a reliable performance.
Isolation and Partial Characterization of Neurofibrillary Tangles and Amyloid Plaque Core in Alzheimer's Disease: Immunohistological Studies

Fractions enriched in neurofibrillary tangles (NFT) and amyloid fibrils were isolated from the cerebral cortex of three cases of senile dementia of the Alzheimer type. Distilled water suspensions of these fractions were excluded from all pore size gels and resisted digestion with various proteolytic enzymes. Formic acid/chloroform treatment of each fraction resulted in the appearance of 4,000–6,000, 15,000–17,000 and 24,000 molecular weight proteins, with concomitant diminution in the amount of excluded material at the top of each gel. The 4,000–6,000 dalton band was best seen in fractions containing randomly arranged amyloid fibrils, and its amino acid composition resembled that of the recently reported “beta‘’ protein. A polyclonal antiserum to purified NFT reacted with tangles in neurons and in dystrophic neurites around plaques by immunoperoxidase staining. No reaction was obtained with cerebrovascular or plaque core amyloid immunohistologically, or with the 4–6 kD protein on immunoblots. Cross-reactivity with the neurofibrillary lesions occurring in Pick's disease, progressive supranuclear palsy, postencephalitic Parkinsonism and dementia pugilistica was also seen. Specific binding of this antiserum to the double filamentous structure was confirmed by immunoelectron microscopy. Although the presence of “beta‘’ protein in both NFT and amyloid-containing fractions suggests that it may be an important constituent of both, cross-contamination cannot be excluded.
Post-perceptual processing during the attentional blink is modulated by inter-trial task expectancies

The selective processing of goal-relevant information depends on an attention system that can flexibly adapt to changing task demands and expectations. Evidence from visual search tasks indicates that the perceptual selectivity of attention increases when the bottom-up demands of the task increase and when the expectations about task demands engendered by trial history are violated. Evidence from studies of the attentional blink (AB), which measures the temporal dynamics of attention, also indicates that perceptual selectivity during the AB is increased if the bottom-up task demands are increased. The present work tested whether expectations about task demands engendered by trial history also modulate perceptual selectivity during the AB. Two experiments tested the extent to which inter-trial switches in task demands reduced post-perceptual processing of targets presented during the AB. Experiment 1 indexed post-perceptual processing using the event-related potential (ERP) technique to isolate the context sensitive N400 ERP component evoked by words presented during the AB. Experiment 2 indexed post-perceptual processing using behavioral performance to determine the extent to which personal names survive the AB. The results of both experiments revealed that both electrophysiological (Exp. 1) and behavioral (Exp. 2) indices of post-perceptual processing were attenuated when consecutive trials differed in terms of their perceptual demands. The results are consistent with the notion that the selectivity of attention during the AB is modulated not only by within-trial task demands, but also can be flexibly determined by trial-by-trial expectations.
Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy

V(D)J recombination of antigen receptor loci (IGH, IGK, IGL, TCRA, TCRB, TCRG, and TCRD) is an essential mechanism that confers enormous diversity to the mammalian immune system. However, there are now at least six examples of intrachromosomal interstitial deletions caused by aberrant V(D)J recombination between nonantigen receptor loci; five of out these six are associated with lymphoid malignancy. The SIL‐SCL fusion and deletions of CDKN2A, IKZF1, Notch1, and Bcl11b are all associated with lymphoid malignancy. These interstitial deletions seem to be species specific, as the deletions seen in mice are not seen in humans; the converse is true as well. Nucleotide sequence analysis of these rearrangements reveals the hallmarks of V(D)J recombination, including site specificity near cryptic heptamer signal sequences, exonucleolytic “nibbling” at the junction site, and nontemplated “N”‐region nucleotide insertion at the junction site. Two of these interstitial deletions (murine Notch1 and Bcl11b deletions) have been detected, at low frequency, in tissues from healthy mice with no evidence of malignancy, similar to the finding of chromosomal translocations in the peripheral blood or tonsils of healthy individuals. The contention that these are mediated via V(D)J recombination is strengthened by in vivo assays using extrachromosomal substrates, and chromatin immunoprecipitation‐sequence analysis which shows Rag2 binding at the sites of rearrangement. Although the efficiency of these “illegitimate” recombination events is several orders of magnitude less than that at bona fide antigen receptor loci, the consequence of such deletions, namely activation of proto‐oncogenes or deletion of tumor suppressor genes, is devastating, and a major cause for lymphoid malignancy. © 2012 Wiley Periodicals, Inc.
Social cognition in pediatric-onset multiple sclerosis (MS)

Background: Pediatric-onset multiple sclerosis (MS) patients represent a subpopulation who are diagnosed during the course of development. Social cognitive deficits have recently been recognized in adults with MS. It is critical to identify whether these youngest patients with the disorder are also at risk. Objective: To determine whether pediatric-onset MS is associated with social cognitive deficits. Methods: Consecutively-recruited participants with pediatric-onset MS were compared to a group of age- and gender-matched healthy controls on Theory of Mind (ToM) task performance. Tasks measured facial affect recognition (Reading the Mind in the Eyes Test), detecting social faux pas (Faux Pas Test), and understanding the perspective of another (False Beliefs Task). Results: Twenty-eight (28) pediatric-onset MS participants (median age 17 years) and 32 healthy controls (median age 16 years) completed the study. The MS participants performed worse than controls on all three ToM tasks: Reading the Mind in the Eyes Test (p = 0.008), the Faux Pas Test (p = 0.009), and the False Beliefs Task (p = 0.06). While more MS than control participants were impaired on a measure of information processing speed (the Symbol Digit Modalities Test; 38% versus 6%), it did not account for the differences in ToM performance. Conclusions: Social cognition may represent an area of cognitive functioning affected by MS in the pediatric-onset population. These processes are especially important to study in younger patients as they may have long range implications for social adjustment, employment, and well-being.