Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence and socioeconomic determinants of leisure time physical activity among Polish farmers.

INTRODUCTION AND OBJECTIVE The aim of this study is to evaluate the leisure time physical activity of Polish farmers in the context of meeting health-related recommendations, and to diagnose the social and economic determinants. The analysis concerned leisure and transportation activities of various intensity and sedentary time. MATERIAL AND METHODS Farmers (n=153) aged over 18 were selected from a representative sample of Polish society (n=2039). In order to evaluate LTPA, the long version of the IPAQ was used. Statistically significant differences between the variables were tested using non-parametric tests. The relationship between the amount of exercise recommended by the WHO and studied socio-demographic criteria was assessed using log-linear analysis. RESULTS The WHO health recommendations were met by 33.3% of farmers. Shares in LTPA (19.1%) and transportation (19.2%) significantly increased the chance of achieving these norms (OR=12.54 and 0.07, respectively). Along with age (≥40 years) and income (≥3000 PLN/Є750) of Polish farmers, the risk of insufficient physical activity increased. Average MET-min/week for LTPA was 299.8±583.4 and transportation - 521.2±1973.9. The average time of sitting during working days was 4.4±2.9, while it was 4.5±3.2 hrs/day during weekends. CONCLUSIONS Health-promoting changes are necessary among Polish farmers, including an increase in the awareness of health benefits and the necessity of undertaking physically active ways of spending leisure time. It seems to be a legitimate action to develop a mini-tourist trail in the rural environment as a means of promoting physical activity also among women aged over 40, and from lower income groups, who are especially threatened by inactivity.
Risk Homeostasis in Information Security: Challenges in Confirming Existence and Verifying Impact

The central premise behind risk homeostasis theory is that humans adapt their behaviors, based on external factors, to align with a personal risk tolerance level. In essence, this means that the safer or more secure they feel, the more likely it is that they will behave in a risky manner. If this effect exists, it serves to restrict the ability of risk mitigation techniques to effect improvements. The concept is hotly debated in the safety area. Some authors agree that the effect exists, but also point out that it is poorly understood and unreliably predicted. Other re-searchers consider the entire concept fallacious. It is important to gain clarity about whether the effect exists, and to gauge its impact if such evidence can indeed be found. In this paper we consider risk homeostasis in the context of information security. Similar to the safety area, information security could well be impaired if a risk homeostasis effect neutralizes the potential benefits of risk mitigation measures. If the risk homeostasis effect does indeed exist and does impact risk-related behaviors, people will simply elevate risky behaviors in response to feeling less vulnerable due to following security procedures and using protective technologies. Here we discuss, in particular, the challenges we face in confirming the existence and impact of the risk homeostasis effect in information security, especially in an era of ethical research practice.
Optimizing the Trade-Off between Single-Stage and Two-Stage Deep Object Detectors using Image Difficulty Prediction

There are mainly two types of state-of-the-art object detectors. On one hand, we have two-stage detectors, such as Faster R-CNN (Region-based Convolutional Neural Networks) or Mask R-CNN, that (i) use a Region Proposal Network to generate regions of interests in the first stage and (ii) send the region proposals down the pipeline for object classification and bounding-box regression. Such models reach the highest accuracy rates, but are typically slower. On the other hand, we have single-stage detectors, such as YOLO (You Only Look Once) and SSD (Singe Shot MultiBox Detector), that treat object detection as a simple regression problem by taking an input image and learning the class probabilities and bounding box coordinates. Such models reach lower accuracy rates, but are much faster than two-stage object detectors. In this paper, we propose to use an image difficulty predictor to achieve an optimal trade-off between accuracy and speed in object detection. The image difficulty predictor is applied on the test images to split them into easy versus hard images. Once separated, the easy images are sent to the faster single-stage detector, while the hard images are sent to the more accurate two-stage detector. Our experiments on PASCAL VOC 2007 show that using image difficulty compares favorably to a random split of the images. Our method is flexible, in that it allows to choose a desired threshold for splitting the images into easy versus hard.
Effects of residual (or internal) stress on ferroelectric domain wall motion in tetragonal lead titanate

The effect of temperature on grinding-induced texture in tetragonal lead titanate (PT) has been investigated as a function of the magnitude of loading applied to the sample surface during grinding, using in situ x-ray diffraction (XRD) with an area detector. Compared to the ground PT under lower loading conditions (5 N), the ground PT under higher loading conditions (40 N) retains strong ferroelastic texture near the Curie temperature ( T _C) around 350 °C and undergoes smaller changes in lattice parameter or tetragonality versus temperature during in situ thermal cycling between room temperature and approximately 100 °C above the T _C. Inhibited depoling of ground PT materials investigated by in situ texture measurements demonstrates the effects of residual stresses.
Examining the effectiveness of using concolic analysis to detect code clones

During the initial construction and subsequent maintenance of an application, duplication of functionality is common, whether intentional or otherwise. This replicated functionality, known as a code clone, has a diverse set of causes and can have moderate to severe adverse effects on a software project in a variety of ways. A code clone is defined as multiple code fragments that produce similar results when provided the same input. While there is an array of powerful clone detection tools, most suffer from a variety of drawbacks including, most importantly, the inability to accurately and reliably detect the more difficult clone types. This paper presents a new technique for detecting code clones based on concolic analysis, which uses a mixture of concrete and symbolic values to traverse a large and diverse portion of the source code. By performing concolic analysis on the targeted source code and then examining the holistic output for similarities, code clone candidates can be consistently identified. We found that concolic analysis was able to accurately and reliably discover all four types of code clones with an average precision of . 8, recall of . 91, F-score of . 85 and an accuracy of . 99.
First analysis and experiments in aerial manipulation using fully actuated redundant robot arm

In this paper we describe a system for aerial manipulation composed of a helicopter platform and a fully actuated seven Degree of Freedom (DoF) redundant industrial robotic arm. We present the first analysis of such kind of systems and show that the dynamic coupling between helicopter and arm can generate diverging oscillations with very slow frequency which we called phase circles. Based on the presented analysis, we propose a control approach for the whole system. The partial decoupling between helicopter and arm - which eliminates the phase circles - is achieved by means of special movement of robotic arm utilizing its redundant DoF. For the underlying arm control a specially designed impedance controller was proposed. In different flight experiments we showcase that the proposed kind of system type might be used in the future for practically relevant tasks. In an integrated experiment we demonstrate a basic manipulation task - impedance based grasping of an object from the environment underlaying a visual object tracking control loop.
Adenosquamous carcinoma of the bile duct: a population-based study

Introduction Adenosquamous carcinoma (ASC) of the bile duct is a rare diagnosis with poorly understood clinicopathological characteristics and disease progression, so identification of the features associated with ASC patient survival is warranted. Materials and methods A population cohort study was performed using prospectively extracted data from the Surveillance, Epidemiology and End Results (SEER) database for patients with histological diagnoses of ASC of the bile duct from 1973 to 2013. Results A total of 106 patients with ASC of the bile duct were included (mean age 68.1±13.5 years). Lesions from 58 patients were in the extrahepatic bile duct and 34 were located at the ampulla of Vater. Fifty-seven patients were categorized with a regional stage, 15 had localized disease, and 30 had distant disease. Most (60.4%) patients received cancer-directed surgery, and radiation was performed in 14.1% of cases. The 1-year, 2-year, and 5-year overall survival (OS) for patients with ASC of the bile duct was 30.1%, 11.3%, and 3.7%, respectively. Cancer-directed surgery offered 10 additional months of OS for patients with ASC of the bile duct and median OS was 14.0, 6.0, and 6.0 months for ampulla of Vater, extrahepatic bile duct, and intrahepatic bile duct cases, respectively. A multivariate Cox analysis showed that lesions in the ampulla of Vater (HR=0.51, 95% CI 0.26–0.99) and having surgery (HR=0.34, 95% CI 0.14–0.81) were independent protective prognostic factors for these patients. Conclusion Cancer-directed surgery and a primary lesion site of the ampulla of Vater may suggest favorable prognosis for patients with ASC of the bile duct.
Mixture toxicity of copper, cadmium, and zinc to barley seedlings is not explained by antioxidant and oxidative stress biomarkers

The analysis of metal mixture toxicity to plants is complicated by mutual interactions. In the present study, mixture effects of zinc (Zn), cadmium (Cd), and copper (Cu) on barley (Hordeum vulgare L.) root elongation were analyzed using oxidative stress parameters. The hypothesis was that toxic mixture effects on plant growth are better explained by biochemical parameters than by exposure information, because the former excludes interactions among metals for root uptake. Barley seedlings were exposed for 5 d or 14 d to these metals in nutrient solutions, added in isolation and as mixtures. Root elongation in Cu+Cd mixtures was well predicted from free metal ion concentrations in solution, using concentration addition (CA) or independent action (IA) reference models. In contrast, Zn acted antagonistically when combined with Cu and/or Cd, relative to both CA and IA. This protective effect of Zn correlated with the biomarkers measured in the long‐term experiment; oxidative stress (indicated by malondialdehyde level, for example) decreased after addition of Zn. In addition, it was found that some biomarkers were sensitive to both Cu and Cd dosed in isolation, but not to Cu+Cd mixtures. Overall, the exposure explained mixture effects better than most of the 16 measured biomarkers (i.e., the biochemical effects). It is concluded that these biomarkers are not robust indicators for metal mixture toxicity, potentially because different metals have different parallel modes of action on growth that are insufficiently indexed by the biomarkers. Environ Toxicol Chem 2017;36:220–230. © 2016 SETAC
Primerize‐2D: automated primer design for RNA multidimensional chemical mapping

Summary : Rapid RNA synthesis of comprehensive single mutant libraries and targeted multiple mutant libraries is enabling new multidimensional chemical approaches to solve RNA structures. PCR assembly of DNA templates and in vitro transcription allow synthesis and purification of hundreds of RNA mutants in a cost‐effective manner, with sharing of primers across constructs allowing significant reductions in expense. However, these protocols require organization of primer locations across numerous 96 well plates and guidance for pipetting, non‐trivial tasks for which informatics and visualization tools can prevent costly errors. We report here an online tool to accelerate synthesis of large libraries of desired mutants through design and efficient organization of primers. The underlying program and graphical interface have been experimentally tested in our laboratory for RNA domains with lengths up to 300 nucleotides and libraries encompassing up to 960 variants. In addition to the freely available Primerize‐2D server, the primer design code is available as a stand‐alone Python package for broader applications. Availability and Implementation : http://primerize2d.stanford.edu Contact: rhiju@stanford.edu Supplementary information: Supplementary data are available at Bioinformatics online.
Intake of fruit and vegetables and the risk of ischemic stroke in a cohort of Danish men and women.

BACKGROUND Previous studies have suggested that a high dietary intake of fruit and vegetables is associated with a reduced risk of ischemic stroke. The magnitude of the effect is uncertain, and only one study reported data on the intake of specific fruit and vegetables and the risk of stroke. OBJECTIVE We examined whether the intake of fruit and vegetables is associated with a reduced risk of ischemic stroke, with particular attention paid to specific fruit and vegetables and subtypes of ischemic stroke. DESIGN In a prospective cohort study of 54,506 men and women who were included in the Danish Diet, Cancer, and Health study from 1993 to 1997, estimated total intakes of fruit and vegetables (in g/d) were extracted from a semiquantitative food-frequency questionnaire completed at baseline. Data about subjects hospitalized with ischemic stroke were obtained from the Danish National Registry of Patients and were verified later by record reviews. The follow-up for ischemic stroke ended on the date of a first hospital admission for stroke or transient ischemic attack, the date of death or emigration, or the end of the study, whichever came first. RESULTS We identified 266 cases of ischemic stroke involving hospitalization during 168,388 person-years of follow-up (median follow-up: 3.09 y; range: 0.02-5.10 y). After adjustment for potential confounders, persons in the top quintile of fruit and vegetable intake (median: 673 g/d) had a risk ratio of ischemic stroke of 0.72 (95% CI: 0.47, 1.12) relative to persons in the bottom quintile of intake (median: 147 g/d) (P for trend = 0.04). When comparing the top quintile with the bottom quintile, an inverse association was most evident for fruit intake (risk ratio: 0.60; 95% CI: 0.38, 0.95; P for trend = 0.02). Similar risk estimates were seen for most types of fruit and vegetables, although the risks were significant only for citrus fruit. CONCLUSION An increased intake of fruit may reduce the risk of ischemic stroke.
Cochlear implantation and single-sided deafness

Purpose of reviewRecently, more patients with single-sided deafness (SSD) have been undergoing cochlear implantation. We review recent studies and case reports to provide an overview of the efficacy of cochlear implants to rehabilitate patients with SSD with regards to sound localization, speech discrimination, and tinnitus suppression. Recent findingsThere are a growing number of studies evaluating the effect of cochlear implantation for rehabilitation of the deficits associated with SSD over the past several years as more centers offer this treatment modality to patients with SSD. Although individual studies have few patients and are underpowered, the vast majority report improvement in sound localization, speech understanding in quiet and noise, and tinnitus. In some cases, the outcomes with cochlear implant appear superior to those achieved with other devices, including contralateral routing of sound devices and osseointegrated implants. SummaryAlthough cochlear implant is not a Food and Drug Administration-approved treatment for SSD, several recent studies show improvements in speech understanding, sound localization, and tinnitus. Because of the low number of cases, it is difficult to conclusively compare outcomes achieved with cochlear implants and those provided by other devices. However, on the basis of encouraging early results and the unique ability to restore binaural sound processing, a growing number of centers offer cochlear implants as treatment for SSD. Forthcoming studies will help define outcome expectations in different populations.
Preparation Cost of Patties from Spent Hen Meat

Chicken patties from spent hen meat were prepared from a standardized formulation and were extended with optimized level of non meat extenders viz sorghum flour, barley flour and pressed rice flour at 5%, 10% and 5% respectively. Optimization of levels for extenders was done under different experiments based on sensory attributes and those having sensory status closer to control were selected. The cost of patties from spent hen meat after replacement of lean with selected level of non meat extenders were compared among themselves to determine the most economic preparation. It was found that extended patties were cheaper than control patties and among the extended patties least cost was for barley flour extended patties. The cost for sorghum flour extended patties and pressed rice flour extended patties were almost same but these were higher than barley flour extended patties because of higher yield and high level of replacement of lean meat in latter case. Thus it was concluded that formulation with extension of 10% barley flour at the cost of lean meat was most economic among the tested non meat extenders.
Aryl Hydrocarbon Receptor Deficiency Alters Circadian and Metabolic Rhythmicity

PAS domain–containing proteins can act as environmental sensors that capture external stimuli to allow coordination of organismal physiology with the outside world. These proteins permit diverse ligand binding and heterodimeric partnership, allowing for varied combinations of PAS-dependent protein-protein interactions and promoting crosstalk among signaling pathways. Previous studies report crosstalk between circadian clock proteins and the aryl hydrocarbon receptor (AhR). Activated AhR forms a heterodimer with the circadian clock protein Bmal1 and thereby functionally inhibits CLOCK/Bmal1 activity. If physiological activation of AhR through naturally occurring, endogenous ligands inhibits clock function, it seems plausible to hypothesize that decreased AhR expression releases AhR-induced inhibition of circadian rhythms. Because both AhR and the clock are important regulators of glucose metabolism, it follows that decreased AhR will also alter metabolic function. To test this hypothesis, rhythms of behavior, metabolic outputs, and circadian and metabolic gene expression were measured in AhR-deficient mice. Genetic depletion of AhR enhanced behavioral responses to changes in the light-dark cycle, increased rhythmic amplitude of circadian clock genes in the liver, and altered rhythms of glucose and insulin. This study provides evidence of AhR-induced inhibition that influences circadian rhythm amplitude.
Type II toxin/antitoxin system ParESO/CopASO stabilizes prophage CP4So in Shewanella oneidensis

Toxin/antitoxin (TA) loci are commonly found in mobile genetic elements such as plasmids and prophages. However, the physiological functions of these TA loci in prophages and cross-regulation among these TA loci remain largely unexplored. Here, we characterized a newly discovered type II TA pair, ParESO /CopASO , in the CP4So prophage in Shewanella oneidensis. We demonstrated that ParESO /CopASO plays a critical role in the maintenance of CP4So in host cells after its excision. The toxin ParESO inhibited cell growth, resulting in filamentous growth and eventually cell death. The antitoxin CopASO neutralized the toxicity of ParESO through direct protein-protein interactions and repressed transcription of the TA operon by binding to a DNA motif in the promoter region containing two inverted repeats [5'-GTANTAC (N)3 GTANTAC-3']. CopASO also repressed transcription of another TA system PemKSO /PemISO in megaplasmid pMR-1 of S. oneidensis through binding to a highly similar DNA motif in its promoter region. CopASO homologs are widely spread in Shewanella and other Proteobacteria, either as a component of a TA pair or as orphan antitoxins. Our study thus illustrated the cross-regulation of the TA systems in different mobile genetic elements and expanded our understanding of the physiological function of TA systems.
OxyR-Dependent Transcription Response of Sinorhizobium meliloti to Oxidative Stress

ABSTRACT Reactive oxygen species such as peroxides play an important role in plant development, cell wall maturation, and defense responses. During nodulation with the host plant Medicago sativa, Sinorhizobium meliloti cells are exposed to H2O2 in infection threads and developing nodules (R. Santos, D. Hérouart, S. Sigaud, D. Touati, and A. Puppo, Mol Plant Microbe Interact 14:86–89, 2001, https://doi.org/10.1094/MPMI.2001.14.1.86). S. meliloti cells likely also experience oxidative stress, from both internal and external sources, during life in the soil. Here, we present microarray transcription data for S. meliloti wild-type cells compared to a mutant deficient in the key oxidative regulatory protein OxyR, each in response to H2O2 treatment. Several alternative sigma factor genes are upregulated in the response to H2O2; the stress sigma gene rpoE2 shows OxyR-dependent induction by H2O2, while rpoH1 expression is induced by H2O2 irrespective of the oxyR genotype. The activity of the RpoE2 sigma factor in turn causes increased expression of two more sigma factor genes, rpoE5 and rpoH2. Strains with deletions of rpoH1 showed improved survival in H2O2 as well as increased levels of oxyR and total catalase expression. These results imply that ΔrpoH1 strains are primed to deal with oxidative stress. This work presents a global view of S. meliloti gene expression changes, and of regulation of those changes, in response to H2O2. IMPORTANCE Like all aerobic organisms, the symbiotic nitrogen-fixing bacterium Sinorhizobium meliloti experiences oxidative stress throughout its complex life cycle. This report describes the global transcriptional changes that S. meliloti makes in response to H2O2 and the roles of the OxyR transcriptional regulator and the RpoH1 sigma factor in regulating those changes. By understanding the complex regulatory response of S. meliloti to oxidative stress, we may further understand the role that reactive oxygen species play as both stressors and potential signals during symbiosis.
Prototypicality Effects in Global Semantic Description of Objects

In this paper, we introduce a novel approach for semantic description of object features based on the prototypicality effects of the Prototype Theory. Our prototype-based description model encodes and stores the semantic meaning of an object, while describing its features using the semantic prototype computed by CNN-classifications models. Our method uses semantic prototypes to create discriminative descriptor signatures that describe an object highlighting its most distinctive features within the category. Our experiments show that: i) our descriptor preserves the semantic information used by the CNN-models in classification tasks; ii) our distance metric can be used as the object's typicality score; iii) our descriptor signatures are semantically interpretable and enables the simulation of the prototypical organization of objects within a category.