Miracle-dz/UniFAR-FTUs huggingface dataset:
Temporal Global Expression Data Reveal Known and Novel Salicylate-Impacted Processes and Regulators Mediating Powdery Mildew Growth and Reproduction on Arabidopsis1[W][OA]

Salicylic acid (SA) is a critical mediator of plant innate immunity. It plays an important role in limiting the growth and reproduction of the virulent powdery mildew (PM) Golovinomyces orontii on Arabidopsis (Arabidopsis thaliana). To investigate this later phase of the PM interaction and the role played by SA, we performed replicated global expression profiling for wild-type and SA biosynthetic mutant isochorismate synthase1 (ics1) Arabidopsis from 0 to 7 d after infection. We found that ICS1-impacted genes constitute 3.8% of profiled genes, with known molecular markers of Arabidopsis defense ranked very highly by the multivariate empirical Bayes statistic (T2 statistic). Functional analyses of T2-selected genes identified statistically significant PM-impacted processes, including photosynthesis, cell wall modification, and alkaloid metabolism, that are ICS1 independent. ICS1-impacted processes include redox, vacuolar transport/secretion, and signaling. Our data also support a role for ICS1 (SA) in iron and calcium homeostasis and identify components of SA cross talk with other phytohormones. Through our analysis, 39 novel PM-impacted transcriptional regulators were identified. Insertion mutants in one of these regulators, PUX2 (for plant ubiquitin regulatory X domain-containing protein 2), results in significantly reduced reproduction of the PM in a cell death-independent manner. Although little is known about PUX2, PUX1 acts as a negative regulator of Arabidopsis CDC48, an essential AAA-ATPase chaperone that mediates diverse cellular activities, including homotypic fusion of endoplasmic reticulum and Golgi membranes, endoplasmic reticulum-associated protein degradation, cell cycle progression, and apoptosis. Future work will elucidate the functional role of the novel regulator PUX2 in PM resistance.
Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging

Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms. A moderate and programmed physical exercise has often been reported to be therapeutic both in the adulthood and in aging, since capable to promote fitness. Regular exercise alleviates the negative effects caused by free radicals and offers many health benefits, including reduced risk of all-cause mortality, sarcopenia in the skeletal muscle, chronic disease, and premature death in elderly people. However, physical performance is also known to induce oxidative stress, inflammation, and muscle fatigue. Many efforts have been carried out to identify micronutrients and natural compounds, also known as nutraceuticals, able to prevent or attenuate the exercise-induced oxidative stress and inflammation. The aim of this review is to discuss the benefits deriving from a constant physical activity and by the intake of antioxidant compounds to protect the body from oxidative stress. The attention will be focused mainly on three natural antioxidants, which are quercetin, resveratrol and curcumin. Their properties and activity will be described, as well as their benefits on physical activity and on aging, which is expected to increase through the years and can get favorable benefits from a constant exercise activity.
Formation of Nanosized Lamellas of a Hardening Intermetallic Phase in the Powder Ni-based Coating Deposited by Microplasma Spraying on Steel Substrates

This paper presents new results of studying the structure-phase compositions of Ni-based powder coating, deposited by Microplasma Spraying onto steel substrate by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray diffraction (XRD). It is shown that we have managed to obtain the predicted specific structure with nanosized lamellas of intermetallic phases due to the appropriate proper selection of modes of additional microplasma processing. As a result, the microhardness of the coating has been increased by 1.25 times.
MIMO communications for inhome PLC networks: Measurements and results up to 100 MHz

Power Line Communications (PLC) is used for information exchange over the lines installed for delivering the electrical power. Inhome PLC is a technology which delivers telecom services to every corner of a household through already existing electrical wiring. In recent years, PLC has emerged as a potential candidate for domestic high bit rate services. The current inhome PLC technology, based on Single-Input Single-Output (SISO) configuration, under achieves the capacity offered by the physical PLC channel. The inhome PLC channel offers multiple signal feed ports as, usually, it comprises of three wires: Phase, Neutral and Protective Earth. The measurements and results presented in this paper demonstrate that up to 90% enhancement in inhome PLC channel capacity is possible by using multiple-input multiple-output (MIMO) technique.
A Modeling Study on the Climate Impacts of Black Carbon Aerosols

The role of black carbon (BC) aerosols in climate change is important because of its strong capability in causing extinction of solar radiation. A three-dimensional interactive aerosol-climate model has been used to study the climatic impact of BC. The interannual variations of BC solar forcing derived from 20-year transient integrations are up to 4 times as large as the means mainly related to changes in cloud cover, snow depth (about ±20% over many highor even mid-latitude regions in Northern Hemisphere) and thus the surface albedo, all caused by BC solar forcing itself. With an absolute amount three times higher than that of the top of the atmosphere (TOA) forcing, the surface forcing of BC is an extremely important factor in analyzing the climate impact of BC. BC aerosols cause a “cloud burning” effect in several polluted regions and a “cloud enhancing” effect in some high-latitude sites. Combined with BC-caused changes in surface albedo, this is defined as a non-Twomey-Albrecht indirect forcing by BC, which alters the radiative budgets by changing cloud cover and some land-surface properties thermodynamically rather than microphysically. The result of this study does not indicate that BC aerosols contribute to a significant increase in land-surface temperature with annual emissions of 14 TgC. The calculated surface temperature change is determined by a subtle balance among changes in surface energy sources and sinks as well as changes in the hydrological cycle, all caused by BC radiative forcing. The result of this study shows that the influence of BC aerosols on climate and environment at the regional scale is more significant than at the global scale. Several important feedbacks between BC radiative effect and climate dynamics revealed in this study suggest the importance of using interactive aerosol-climate models to address the issues related to the climate impacts of aerosols.
Examining intention to adopt to internet of things in healthcare technology products

The purpose of the study is to investigate critical factors affecting individuals’ intention to adopt internet of things (IoT) products in healthcare. ,An integrated model was developed based on technology acceptance model (TAM), innovation diffusion theory (IDT), technological innovativeness (TI), protection motivation theory and privacy calculus theory. The model was tested with 426 respondents (222 females, 204 males) using partial least square structural equation model with all data grouped by gender. ,Based on the results of the complete model, perceived advantage (PA), image and perceived ease of use (PEOU) constructs have a significant effect on intention to adopt IoT healthcare technology products. The results show that for females, compatibility and trialability have more impact on PEOU whereas for males PA has more impact on PEOU. Image, perceived privacy risk, perceived vulnerability have more impact on males when compared to females. ,Research conducted only among Turkish people. ,This study investigated adoption of future technology, “internet of things”, products in healthcare from a behavioral perspective by integrating various theories. The reason is that before launching any technology into the market, its facilitative factors should be researched for the people who are going to use this in their daily routine.
Microstructures, Textures and Mechanical Properties Evolution during Cold Drawing of Pure Mg

Pure Mg wires with a maximum cumulative area reduction of 98% were obtained by successful cold drawing. Mechanical properties, microstructures and texture evolution of the as-drawn wires were investigated by tensile tests, transmission electron microscopy (TEM) and electron backscattering diffraction (EBSD). Depended on the mechanical properties and microstructure evolution, continuous dynamic recrystallization (DRX) had taken place during the cold drawing process. DRX during cold deformation has not been reported in other literatures before.
Optimising the javelin throw in the presence of prevailing winds

Javelin flight is strictly governed by the laws of aerodynamics but there remain well-entrenched but misleading views about the factors involved. This paper gives a simplified but fundamentally accurate view of the physics and dynamics of javelin flight and describes a freely downloadable software implementation of these. The model has been calibrated against two sets of published competition data and predicts distances within about 1%. Finally, it goes on to show how throwing parameters can be optimised for given prevailing wind force and direction.
MYCN is a novel oncogenic target in adult B‐ALL that activates the Wnt/β‐catenin pathway by suppressing DKK3

Dickkopf‐3 (DKK3) is frequently down‐regulated by promoter hypermethylation and is closely associated with a poor prognosis in many cancers. Our previous studies have shown that miR‐708 down‐regulates DKK3 at the post‐transcriptional level in B‐ALL. However, whether transcriptional mechanisms lead to DKK3 silencing remains unclear. Here, we analysed the promoter regions of DKK3 by bioinformatics and found binding sites for MYCN. A dual‐luciferase reporter gene assay and ChIP experiments revealed that MYCN negatively regulates DKK3 at the transcriptional level in B‐ALL cell lines, and using bisulphite sequencing PCR, we affirmed that MYCN has no effect on the methylation of the DKK3 promoter. MYCN silencing in B‐ALL cells resulted in reduced cell proliferation, increased apoptosis and G1 phase arrest. Treatment with MYCN siRNA or 5‐aza‐2′‐deoxycytidine (5‐AdC), a demethylating agent, significantly increased the levels of DKK3 mRNA and protein and decreased the protein levels of p‐GSK3β and nuclear β‐catenin, which indicates inhibition of the Wnt/β‐catenin pathway in vitro. MYCN knockdown significantly decreased the tumorigenic capacity of Nalm6 cells, which restored DKK3 levels and inhibited the Wnt/β‐catenin pathway in vivo. Our study provides an increased understanding of adult B‐ALL pathogenesis, which may be beneficial to the development of effective prognostic markers or therapeutic targets.
Zoonosis emergence linked to agricultural intensification and environmental change

A systematic review was conducted by a multidisciplinary team to analyze qualitatively best available scientific evidence on the effect of agricultural intensification and environmental changes on the risk of zoonoses for which there are epidemiological interactions between wildlife and livestock. The study found several examples in which agricultural intensification and/or environmental change were associated with an increased risk of zoonotic disease emergence, driven by the impact of an expanding human population and changing human behavior on the environment. We conclude that the rate of future zoonotic disease emergence or reemergence will be closely linked to the evolution of the agriculture–environment nexus. However, available research inadequately addresses the complexity and interrelatedness of environmental, biological, economic, and social dimensions of zoonotic pathogen emergence, which significantly limits our ability to predict, prevent, and respond to zoonotic disease emergence.
Increased Failure Rate of Autologous Chondrocyte Implantation after Previous Treatment with Marrow Stimulation Techniques

Background Marrow stimulation techniques such as drilling or microfracture are first-line treatment options for symptomatic cartilage defects. Common knowledge holds that these treatments do not compromise subsequent cartilage repair procedures with autologous chondrocyte implantation. Hypothesis Cartilage defects pretreated with marrow stimulation techniques will have an increased failure rate. Study Design Cohort study; Level of evidence, 2. Methods The first 321 consecutive patients treated at one institution with autologous chondrocyte implantation for full-thickness cartilage defects that reached more than 2 years of follow-up were evaluated by prospectively collected data. Patients were grouped based on whether they had undergone prior treatment with a marrow stimulation technique. Outcomes were classified as complete failure if more than 25% of a grafted defect area had to be removed in later procedures because of persistent symptoms. Results There were 522 defects in 321 patients (325 joints) treated with autologous chondrocyte implantation. On average, there were 1.7 lesions per patient. Of these joints, 111 had previously undergone surgery that penetrated the subchondral bone; 214 joints had no prior treatment that affected the subchondral bone and served as controls. Within the marrow stimulation group, there were 29 (26%) failures, compared with 17 (8%) failures in the control group. Conclusion Defects that had prior treatment affecting the subchondral bone failed at a rate 3 times that of nontreated defects. The failure rates for drilling (28%), abrasion arthroplasty (27%), and microfracture (20%) were not significantly different, possibly because of the lower number of microfracture patients in this cohort (25 of 110 marrow-stimulation procedures). The data demonstrate that marrow stimulation techniques have a strong negative effect on subsequent cartilage repair with autologous chondrocyte implantation and therefore should be used judiciously in larger cartilage defects that could require future treatment with autologous chondrocyte implantation.
A Theory of Life in the Round

This study addresses ways in which inmates at the only maximum-security prison for women in Neuse City (in the northeastern United States) redefine their social world in order to survive incarceration. An aim of the project is to engage in theory building in order to examine the experiences of a world that is “lived in the round. ” A life in the round is a public form of life. It is a lifestyle with an enormous degree of imprecision. Yet, it is this inexactitude that provides an acceptable level of certainty. This way of life sets standards by which one constructs everyday meaning from reality. It is a “takenfor-granted,” “business-as-usual” style of being. Relying on ethnographic research and interviews with 80 women at the prison, the findings revealed that a life in the round was sustaining a “normative” existence.
The Effects of Synbiotic Supplementation on Body Mass Index, Metabolic and Inflammatory Biomarkers, and Appetite in Patients with Metabolic Syndrome: A Triple-Blind Randomized Controlled Trial

ABSTRACT It has been shown recently that metabolic syndrome is associated with gut dysbiosis. The gut microbiota may be the main target for prevention or treatment of metabolic syndrome. We investigated the effects of synbiotic supplementation on metabolic syndrome. In this triple-blinded clinical trial, 46 Iranian patients with metabolic syndrome, from both sexes, aged 25–70 years, who fulfilled inclusion criteria were randomly categorized to receive either the synbiotic or a placebo capsule, twice a day for three months, plus a weight-loss diet using stratified random sampling based on body mass index (BMI). Each synbiotic capsule consisted of seven strains probiotic bacteria (2× 108) plus fructooligosaccharide as a prebiotic. Anthropometric measurements and biochemical tests were assessed at baseline and at the end of week 12 for fasting blood sugar (FBS), insulin, lipid profile, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), peptide YY (PYY), and glucagon-like peptide-1 (GLP-1). The mean changes of weight, BMI, FBS, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), and GLP-1 between the two groups was statistically significant (p < .001). Furthermore, peptide YY (PYY) increased significantly in the synbiotic group (p ≤ .05). The trend of weight loss in the synbiotic group was significant until the end of the study (p < .001) while it stopped at week 6 in the placebo group. Synbiotic treatment may improve the status of BMI, FBS, insulin resistance, HOMA-IR, GLP-1, and PYY in patients with metabolic syndrome.
Adaptation of the Structured Clinical Interview for DSM-IV Disorders for assessing depression in women during pregnancy and post-partum across countries and cultures

Background To date, no study has used standardised diagnostic assessment procedures to determine whether rates of perinatal depression vary across cultures. Aims To adapt the Structured Clinical Interview for DSM–IV Disorders (SCID) for assessing depression and other non-psychotic psychiatric illness perinatally and to pilot the instrument in different centres and cultures. Method Assessments using the adapted SCID and the Edinburgh Postnatal Depression Scale were conducted during the third trimester of pregnancy and at 6 months postpartum with 296 women from ten sites in eight countries. Point prevalence rates during pregnancy and the postnatal period and adjusted 6-month period prevalence rates were computed for caseness, depression and major depression. Results The third trimester and 6-month point prevalence rates for perinatal depression were 6.9% and 8.0%, respectively. Postnatal 6-month period prevalence rates for perinatal depression ranged from 2.1% to 31.6% across centres and there were significant differences in these rates between centres. Conclusions Study findings suggest that the SCID was successfully adapted for this context. Further research on determinants of differences inprevalence of depression across cultures isneeded.
The Relationship Between TSH Levels and Body Mass Index in Overweight Euthyroid Subjects: Role of Autoimmunity

Summary: Also if a positive correlation between TSH and BMI has been observed in the majority of the studies, data on this topic remain controversial, especially when TSH values are in normal range. However, it is reasonable to argue that the high-normal levels of TSH found in obesity can be partly attributed to a silent autoimmune thyroiditis. The aim of the present study was to evaluate the interconnection between TSH and autoimmunity in obese patients with TSH values within the normal range. Methods: We enrolled 891 overweight and obese patients (209 Males), with TSH values in normal range (mean age ± SD: 45.1 ± 15 years. Anti thyroid auto antibodies(ATAs: thyroid-peroxides auto antibodies (TPOAb) and/or thyroglobulin auto antibodies(TgAb) and TSH were measured in all patients. The entire sample was then subdivided according to the tertiles of TSH within the range between 0.4 and 4.1 μUI/L. Results: No significant correlation between TSH and BMI was found within these groups. According to the presence (ATA+) or absence (ATA-) of ATAs, we found 225 (25,4%) ATA+ (32 males) and 665 ATA(177 males) patients. A statistically significant correlation between TSH and BMI was found only in females with ATA positivity (Pearson: r = 0.1426, p= 0.04; Spearman: r = 0.1616, p = 0.02). Conclusion: In the initial assessment of obesity, the determination of TSH could be associate to ATAs, for identifying, among the patients with increased TSH, those affected by autoimmune thyroiditis. We suggest that in these patients, the beginning of LT4 therapy could be taken into account.
Estimation of Pup Production of Hooded and Harp Seals in the Greenland Sea in 2007: Reducing Uncertainty Using Generalized Additive Models

The pup production of the Greenland Sea populations of hooded and harp seals were assessed in aerial surveys using two aircrafts for reconnaissance flights and photographic surveys along transects over the whelping areas from 14 March to 3 April 2007. One helicopter, operated from the applied expedition vessel, flew reconnaissance flights, monitored the distribution of seal patches and performed age-staging of the pups. The total estimate of hooded seal pup production was 16 140 (SE = 2 140, CV = 13.3%), which is similar to an estimate obtained for comparable surveys in 2005. The total pup production estimate obtained for harp seals was 110 530 (SE = 27 680, CV = 25.0%), which is slightly higher than an estimate obtained for a similar survey in 2002. The pup production and the uncertainty of the pup production estimate were estimated using a standard method for analyzing this type of survey data and a recently developed method that utilized Generalized Additive Models (GAMs). Using the two estimation methods on data from all three surveys (2002, 2005, 2007), comparable estimates of pup production were obtained. In scenarios where pups were clustered, the estimated uncertainty of the pup production estimate was much lower for the GAM method than for the conventional method. This resulted in a considerable reduction of the estimated coefficient of variation. In scenarios where pups were uniformly distributed, both methods performed the same.
Noise Exposure and Hearing Loss in Classical Orchestra Musicians: A Five-Year Follow-Up

Introduction: This study is a follow-up to prior research from our group that attempts to relate noise exposure and hearing thresholds in active performing musicians of the National Ballet of Canada Orchestra. Materials and Methods: Exposures obtained in early 2010 were compared to exposures obtained in early 2017 (the present study). In addition, audiometric thresholds obtained in early 2012 were compared to thresholds obtained in early 2017 (the present study). This collection of measurements presents an opportunity to observe the regularities in the patterns of exposure as well as threshold changes that may be expected in active orchestra musicians over a 5-year span. Results: The pattern of noise exposure across instrument groups, which was consistent over the two time points, reveals highest exposures among brass, percussion/basses, and woodwinds. However, the average noise exposure across groups and time was consistently below 85 dBA, which suggests no occupational hazard. These observations were corroborated by audiometric thresholds, which were generally (a) in the normal range and (b) unchanged in the 5-year period between measurements. Conclusion: Because exposure levels were consistently below 85 dBA and changes in audiometric thresholds were minimal, we conclude that musicians experienced little-to-no risk of noise-induced hearing loss.