Miracle-dz/UniFAR-FTUs huggingface dataset:
Nurses' intention to remain employed in hospitals: Understanding the shortage in the context of Myanmar

PURPOSE This study aims to ascertain the rate and identify the factors associated with nurses' intention to remain employed at hospitals in the Yangon Region. METHODS A cross-sectional descriptive study was conducted among 300 nurses aged between 20 and 60 years working at both private and public hospitals in the Yangon Region during May to June 2015. Chi-square tests were used to identify factor associations, and multiple logistic regression was examined to determine predictive factors. RESULTS The study revealed that 63.6% of nurses intended to remain employed. Marital status (adjusted odd ratio: 2.22; 95% confidence interval [CI]: 1.05-4.32), work characteristics (adjusted odd ratio: 2.42; 95% CI: 1.33-4.41), job stress and burnout (adjusted odd ratio: 1.77; 95% CI: 1.01-3.11), and recognition (adjusted odd ratio: 1.96; 95% CI: 1.07-3.59) were found to be significant predictors of nurses' intention to remain employed at the hospitals. CONCLUSIONS Recognition and other nonmonetary incentive support systems should be provided to enhance the retention of nurses at the hospitals.
Propofol Protects Against Hemorrhagic Shock-Induced Organ Damage in Conscious Spontaneously Hypertensive Rats

Patients with hypertension have higher mortality rates from hemorrhagic shock (HS) than normotensive patients. Several inflammatory mediators such as tumor necrosis factor a (TNF-a) and interleukin 10 (IL-10) can be produced by HS and lead to multiple organ dysfunction and death. We investigated the effects of high dose (10 mg/kg/hr) and low dose (1 mg/kg/hr) propofol treatment after HS in conscious spontaneously hypertensive rats (SHRs). By withdrawing 40% of total blood volume from a femoral arterial catheter (6 ml/100 g body weight [BW]) for more than 30 min, HS was induced. The mean arterial pressure (MAP) and heart rate (HR) were monitored continuously for 24 hr after the start of blood withdrawal. Levels of biochemical parameters, including glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), blood urea nitrogen (BUN), creatinine (Cre), creatine phosphokinase (CPK), and lactic dehydrogenase (LDH) were measured 30 min before and 0, 1, 3, 6, 9, 12, 18, and 24 hr after the 30-min blood withdrawal period. Cytokine levels, including TNF-a and IL-10 in the serum, were measured 1 hr after HS. The kidney, liver, and lung were removed for pathology assessment at 48 hr after HS. HS significantly increased blood GOT, GPT, BUN, LDH, CPK, TNF-a, and IL-10 levels in conscious SHRs. Posttreatment propofol decreased serum TNF-a level, increased serum IL-10 level, attenuated the severity of organ damage, and improved survival rate after HS. This treatment protected SHRs against HS-induced organ damage. Moreover, high-dose propofol had a more protective effect than low-dose propofol against HS in conscious SHRs.
Towards Symbolic Reinforcement Learning with Common Sense

Deep Reinforcement Learning (deep RL) has made several breakthroughs in recent years in applications ranging from complex control tasks in unmanned vehicles to game playing. Despite their success, deep RL still lacks several important capacities of human intelligence, such as transfer learning, abstraction and interpretability. Deep Symbolic Reinforcement Learning (DSRL) seeks to incorporate such capacities to deep Q-networks (DQN) by learning a relevant symbolic representation prior to using Q-learning. In this paper, we propose a novel extension of DSRL, which we call Symbolic Reinforcement Learning with Common Sense (SRL+CS), offering a better balance between generalization and specialization, inspired by principles of common sense when assigning rewards and aggregating Q-values. Experiments reported in this paper show that SRL+CS learns consistently faster than Q-learning and DSRL, achieving also a higher accuracy. In the hardest case, where agents were trained in a deterministic environment and tested in a random environment, SRL+CS achieves nearly 100% average accuracy compared to DSRL's 70% and DQN's 50% accuracy. To the best of our knowledge, this is the first case of near perfect zero-shot transfer learning using Reinforcement Learning.
Digital Outdoor Play: Benefits and Risks from an Interaction Design Perspective

Outdoor play has been proven to be beneficial for children's development. HCI research on Heads-Up Games suggests that the well-known decline in outdoor play can be addressed by adding technology to such activities. However, outdoor play benefits such as social interaction, creative thinking, and physical activity may be compromised when digital features are added. We present the design & implementation of a novel digitally-enhanced outdoor-play prototype. Our evaluation with 48 children revealed that a non-digital version of the novel outdoor play object afforded social play and game invention. Evaluation of the digitally-enhanced version showed reduced collaborative social interaction and reduced creative thinking when compared with baseline. However, we showed that specific sensing and feedback features better supported outdoor play benefits. For example non-accumulated feedback was shown to increase collaborative play and creative thinking in comparison to accumulated feedback. We provide evidence-based recommendations for designers of outdoor play technologies.
Requirement of Ras-Dependent Pathways for Activation of the Transforming Growth Factor β3 Promoter by Estradiol**This work was supported by the Canadian Institutes of Health Research and the National Cancer Institute of Canada through the Canadian Breast Cancer Research Initiative program.

It has been previously observed that the transforming growth factorβ 3 (TGFβ3) gene can be activated by both estradiol (E2) and selective estrogen receptor modulators (SERMs) in vivo but that only SERMs have a potent stimulatory effect on the TGFβ3 promoter in cultured cells. We demonstrate in this report that E2 can act also as a potent inducer of the TGFβ3 promoter via a novel and specific estrogen receptor (ER)α-mediated mechanism. Our results show that treatment with epidermal growth factor or transfection of a constitutively active Ras mutant allows E2 to induce the TGFβ3 promoter via ERα in cotransfected HeLa and osteosarcoma MG63 cells. Both protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) inhibitors can block the combined stimulatory effect of E2 and epidermal growth factor/Ras. However, E2 induction of the TGFβ3 promoter was found to be unaffected by mutation of ERα serine 118, a well-characterized target of MAPK. Progressive deletion analysis of the ERα amino-terminal region de.
Cell Distribution Striking But Temporary Changes in Splenic Mice Induces Strong B Cell Responses and Infection in Plasmodium chabaudi chabaudi

B cells and Abs play a key role in controlling the erythrocytic stage of malaria. However, little is known about the way the humoral response develops during infection. We show that Plasmodium chabaudi chabaudi causes major, but temporary changes in the distribution of leukocytes in the spleen. Despite these changes, an ordered response to infection develops, which includes vigorous extrafollicular growth of plasmablasts and germinal center formation. Early in the response, the lymphocytes in the T zone and follicles become widely spaced, and the edges of these compartments blur. This effect is maximal around the peak of parasitemia. Germinal centers are apparent by day 8, peak at day 20, and persist through day 60. Extrafollicular foci of plasmablasts are visible from day 4 and initiate a very strong plasma cell response. Initially, the plasma cells have a conventional red pulp distribution, but by day 10 they are unconventionally sited in the periarteriolar region of the white pulp. In this region they form clusters occupying part of the area normally ﬁlled by T cells. B cells are absent from the marginal zone for at least 30 days after the peak of infection, although ﬂow cytometry shows their continued presence in the spleen throughout infection. Relatively normal splenic architecture is regained by day 60 of infection. These results show that the changes in splenic cell distribution are linked to the presence of parasites and do not seem to interfere with the development of the humoral response. The Journal of Immunology, 2003, 171: 317–324.
Revisiting Domestic Savings and Economic Growth Analysis in Ghana

This study set out to ascertain the relationship between domestic savings and economic growth in the midst of antecedent variables with yearly data during the period of 1970-2013. Using Johansen cointegration test and vector error correction model, the study found that, in the long-run, consumer price index, trade openness, foreign direct investment, and domestic savings have positive significant impacts on economic growth. With respect to the shortrun estimates, the lags in domestic savings have negative but insignificant effects on economic growth. It is, therefore, incumbent on the government to uphold, guard, and sustain the political stability so jealously since it can create a conducive financial atmosphere necessary to mobilise savings in order to improve the growth rate of the Ghanaian economy. It is also recommended that the central bank pays a particular attention to rural savings mobilisation through the regulation of mobile banking by allowing the telecommunication companies to also pay interest to savers on their mobile deposits and establishment of banking financial institutions at least in each district in Ghana.
The Quiver of the Semigroup Algebra of a Left Regular Band

Recently it has been noticed that many interesting combinatorial objects belong to a class of semigroups called left regular bands, and that random walks on these semigroups encode several well-known random walks. For example, the set of faces of a hyperplane arrangement is endowed with a left regular band structure. This paper studies the module structure of the semigroup algebra of an arbitrary left regular band, extending results for the semigroup algebra of the faces of a hyperplane arrangement. In particular, a description of the quiver of the semigroup algebra is given and the Cartan invariants are computed. These are used to compute the quiver of the face semigroup algebra of a hyperplane arrangement and to show that the semigroup algebra of the free left regular band is isomorphic to the path algebra of its quiver.
Detrimental role of prolonged sleep deprivation on adult neurogenesis

Adult mammalian brains continuously generate new neurons, a phenomenon called adult neurogenesis. Both environmental stimuli and endogenous factors are important regulators of adult neurogenesis. Sleep has an important role in normal brain physiology and its disturbance causes very stressful conditions, which disrupt normal brain physiology. Recently, an influence of sleep in adult neurogenesis has been established, mainly based on sleep deprivation studies. This review provides an overview on how rhythms and sleep cycles regulate hippocampal and subventricular zone neurogenesis, discussing some potential underlying mechanisms. In addition, our review highlights some interacting points between sleep and adult neurogenesis in brain function, such as learning, memory, and mood states, and provides some insights on the effects of antidepressants and hypnotic drugs on adult neurogenesis.
Revisiting Batch Normalization For Practical Domain Adaptation

Deep neural networks (DNN) have shown unprecedented success in various computer vision applications such as image classification and object detection. However, it is still a common annoyance during the training phase, that one has to prepare at least thousands of labeled images to fine-tune a network to a specific domain. Recent study (Tommasi et al. 2015) shows that a DNN has strong dependency towards the training dataset, and the learned features cannot be easily transferred to a different but relevant task without fine-tuning. In this paper, we propose a simple yet powerful remedy, called Adaptive Batch Normalization (AdaBN) to increase the generalization ability of a DNN. By modulating the statistics in all Batch Normalization layers across the network, our approach achieves deep adaptation effect for domain adaptation tasks. In contrary to other deep learning domain adaptation methods, our method does not require additional components, and is parameter-free. It archives state-of-the-art performance despite its surprising simplicity. Furthermore, we demonstrate that our method is complementary with other existing methods. Combining AdaBN with existing domain adaptation treatments may further improve model performance.
Structural, optical, and electrical properties of silicon nanowires for solar cells

We investigated Si nanowires (SiNWs) fabricated by wet etching and chemical vapor deposition (CVD), and core-shell structures, formed by depositing silicon layers around the SiNWs, with respect to their crystallinity, the doping level, and the influence of surface passivation on carrier lifetime. The effects expected to be critical to improve the performance of nanowire-based solar cells are discussed.
Liposuction induces a compensatory increase of visceral fat which is effectively counteracted by physical activity: a randomized trial.

CONTEXT Liposuction is suggested to result in long-term body fat regain that could lead to increased cardiometabolic risk. We hypothesized that physical activity could prevent this effect. OBJECTIVE Our objective was to investigate the effects of liposuction on body fat distribution and cardiometabolic risk factors in women who were either exercise trained or not after surgery. DESIGN, SETTING, AND PARTICIPANTS Thirty-six healthy normal-weight women participated in this 6-month randomized controlled trial at the University of Sao Paulo, Sao Paulo, Brazil. INTERVENTIONS Patients underwent a small-volume abdominal liposuction. Two months after surgery, the subjects were randomly allocated into two groups: trained (TR, n = 18, 4-month exercise program) and nontrained (NT, n = 18). MAIN OUTCOME MEASURES Body fat distribution (assessed by computed tomography) was assessed before the intervention (PRE) and 2 months (POST2), and 6 months (POST6) after surgery. Secondary outcome measures included body composition, metabolic parameters and dietary intake, assessed at PRE, POST2, and POST6, and total energy expenditure, physical capacity, and sc adipocyte size and lipid metabolism-related gene expression, assessed at PRE and POST6. RESULTS Liposuction was effective in reducing sc abdominal fat (PRE vs. POST2, P = 0.0001). Despite the sustained sc abdominal fat decrement at POST6 (P = 0.0001), the NT group showed a significant 10% increase in visceral fat from PRE to POST6 (P = 0.04; effect size = -0.72) and decreased energy expenditure (P = 0.01; effect size = 0.95) when compared with TR. Dietary intake, adipocyte size, and gene expression were unchanged over time. CONCLUSION Abdominal liposuction does not induce regrowth of fat, but it does trigger a compensatory increase of visceral fat, which is effectively counteracted by physical activity.
Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence

ABSTRACT We describe here the identification and characterization of two Listeria monocytogenes (Tn917-LTV3) relA and hpt transposon insertion mutants that were impaired in growth after attachment to a model surface. Both mutants were unable to accumulate (p)ppGpp in response to amino acid starvation, whereas the wild-type strain accumulated (p)ppGpp within 30 min of stress induction. The induction of transcription of the relA gene after adhesion was demonstrated, suggesting that the ability to mount a stringent response and undergo physiological adaptation to nutrient deprivation is essential for the subsequent growth of the adhered bacteria. The absence of (p)ppGpp in the hpt mutant, which is blocked in the purine salvage pathway, is curious and suggests that a functional purine salvage pathway is required for the biosynthesis of (p)ppGpp. Both mutants were avirulent in a murine model of listeriosis, indicating an essential role for the stringent response in the survival and growth of L. monocytogenes in the host. Taken as a whole, this study provides new information on the role of the stringent response and the physiological adaptation of L. monocytogenes for biofilm growth and pathogenesis.
Plasma and Muscle Myostatin in Relation to Type 2 Diabetes

Objective Myostatin is a secreted growth factor expressed in skeletal muscle tissue, which negatively regulates skeletal muscle mass. Recent animal studies suggest a role for myostatin in insulin resistance. We evaluated the possible metabolic role of myostatin in patients with type 2 diabetes and healthy controls. Design 76 patients with type 2 diabetes and 92 control subjects were included in the study. They were matched for age, gender and BMI. Plasma samples and biopsies from the vastus lateralis muscle were obtained to assess plasma myostatin and expression of myostatin in skeletal muscle. Results Patients with type 2 diabetes had higher fasting glucose (8.9 versus 5.1 mmol/L, P<0.001), plasma insulin (68.2 versus 47.2 pmol/L, P<0.002) and HOMA2-IR (1.6 versus 0.9, P<0.0001) when compared to controls. Patients with type 2 diabetes had 1.4 (P<0.01) higher levels of muscle myostatin mRNA content than the control subjects. Plasma myostatin concentrations did not differ between patients with type 2 diabetes and controls. In healthy controls, muscle myostatin mRNA correlated with HOMA2-IR (r = 0.30, P<0.01), plasma IL-6 (r = 0.34, P<0.05) and VO2 max (r = −0.26, P<0.05), however, no correlations were observed in patients with type 2 diabetes. Conclusions This study supports the idea that myostatin may have a negative effect on metabolism. However, the metabolic effect of myostatin appears to be overruled by other factors in patients with type 2 diabetes.
Periodontitis and quality of life: What is the role of socioeconomic status, sense of coherence, dental service use and oral health practices? An exploratory theory‐guided analysis on a Norwegian population

AIM To utilise Andersen's behavioural model for health services' use as the theoretical framework to examine direct and indirect relationships between population characteristics, oral health behaviours and periodontitis and oral health impacts. MATERIALS AND METHODS The model was tested in a general adult population (n = 1,886) in Norway, using structural equation modelling. Socioeconomic status, sense of coherence (SOC), dental anxiety, perceived treatment need, oral health behaviours and oral health impact profile (OHIP-14) were collected through questionnaire. Periodontal examinations consisted of full-mouth recordings. RESULTS Andersen's model explained a large part of the variance in use of dental services (58%) and oral health-related impacts (55%), and to a less extent periodontitis (19%). More social structure and stronger SOC was related to more enabling resources, which in turn was associated with more use of dental services. More use of dental services was related to more periodontitis and more periodontitis was associated with increased oral health impacts. A stronger SOC was associated with less oral impacts. There was no association between use of dental services and oral health impacts. CONCLUSIONS The result demonstrated complex relationships between population characteristics, oral health-related behaviours and oral health outcomes. Socioeconomic factors and smoking were main predictors of periodontitis. Regular dental visiting habits did not, however, reduce the likelihood of periodontitis.
Exudates and optic disk detection in retinal images of diabetic patients

Diabetic retinopathy is the progressive pathological alterations in the retinal microvasculature that very often causes blindness. Because of its clinical significance, it will be helpful to have regular cost‐effective eye screening for diabetic patients by developing algorithms to perform retinal image analysis, fundus image enhancement, and monitoring. The two cost‐effective algorithms are proposed for exudates detection and optic disk extraction aimed for retinal images classification and diagnosis assistance. They represent the effort made to offer a cost‐effective algorithm for optic disk identification, which will enable easier exudates extraction, exudates detection and retinal images classification aimed to assist ophthalmologists while making diagnoses. The proposed algorithms apply mathematical modeling, which enables light intensity levels emphasis, easier optic disk and exudates detection, efficient and correct classification of retinal images. The algorithm is robust to various appearance changes of retinal fundus images and shows very promising results. Fundus images are classified into those that are healthy and those affected by diabetes, based on the detected optic disk and exudates. The obtained results indicate that the proposed algorithm successfully and correctly classifies more than 98% of the observed retinal images because of the changes in the appearance of retinal fundus images typically encountered in clinical environments. Copyright © 2014 John Wiley & Sons, Ltd.
Suppressing Unwanted Memories

When reminded of something we would prefer not to think about, we often try to exclude the unwanted memory from awareness. Recent research indicates that people control unwanted memories by stopping memory retrieval, using mechanisms similar to those used to stop reflexive motor responses. Controlling unwanted memories is implemented by the lateral prefrontal cortex, which acts to reduce activity in the hippocampus, thereby impairing retention of those memories. Individual differences in the efficacy of these systems may underlie variation in how well people control intrusive memories and adapt in the aftermath of trauma. This research supports the existence of an active forgetting process and establishes a neurocognitive model for inquiry into motivated forgetting.
Pulsed radiofrequency stimulation suppresses palmar hyperhidrosis in an animal study

Palmar hyperhidrosis (PH) exhibits excessive and unpredictable sweating. The most effective treatment for permanent cure is the ablation of thoracic sympathetic ganglia innervating hands. However, sympathectomy of T2 sympathetic ganglion by clipping or cauterization causes irreversible nerve damage, and results in a compensatory hyperhidrosis (CH). We herein used the pulsed radiofrequency (PRF) stimulation to reversibly block sympathetic ganglion to treat PH and avoid CH.
Oxidation Enhances Human Serum Albumin Thermal Stability and Changes the Routes of Amyloid Fibril Formation

Oxidative damages are linked to several aging-related diseases and are among the chemical pathways determining protein degradation. Specifically, interplay of oxidative stress and protein aggregation is recognized to have a link to the loss of cellular function in pathologies like Alzheimer's and Parkinson's diseases. Interaction between protein and reactive oxygen species may indeed induce small changes in protein structure and lead to the inhibition/modification of protein aggregation process, potentially determining the formation of species with different inherent toxicity. Understanding the temperate relationship between these events can be of utmost importance in unraveling the molecular basis of neurodegeneration. In this work, we investigated the effect of hydrogen peroxide oxidation on Human Serum Albumin (HSA) structure, thermal stability and aggregation properties. In the selected conditions, HSA forms fibrillar aggregates, while the oxidized protein undergoes aggregation via new routes involving, in different extents, specific domains of the molecule. Minute variations due to oxidation of single residues affect HSA tertiary structure leading to protein compaction, increased thermal stability, and reduced association propensity.