Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioequivalence of a Darunavir/Cobicistat Fixed-Dose Combination Tablet versus Single Agents and Food Effect in Healthy Volunteers

Background Darunavir requires pharmacokinetic enhancement to increase its bioavailability. Cobicistat is potentially an alternative pharmacokinetic booster to ritonavir. Bioequivalence of a darunavir/cobicistat fixed-dose combination (FDC) versus darunavir and cobicistat co-administered as single agents and the effect of a high-fat meal on the pharmacokinetics of the FDC were evaluated. Methods In this Phase I, open-label, randomized, three-panel, crossover study (NCT01619527), healthy volunteers received a single dose of darunavir (800 mg) with cobicistat (150 mg) as either an FDC or as single agents co-administered under fasted (panel 1, n=74) or fed (breakfast, panel 2, n=40) conditions, or as the FDC under fasted versus fed (high-fat breakfast) conditions (panel 3, n=19), with a ≥7 day washout period between treatments. Pharmacokinetic profiles, safety and tolerability were assessed. Results 90% confidence intervals of the least square mean ratios for darunavir and cobicistat maximum plasma concentration and area under the plasma concentration–time curve (AUC) were all within 80.00% and 125.00% in panels 1 and 2. Administration of the FDC with a high-fat breakfast significantly increased darunavir maximum plasma concentration 2.27-fold and AUC 1.63–1.70-fold, whereas cobicistat pharmacokinetics were unaffected. No volunteers discontinued due to adverse events (AEs). All AEs were grade 1 or 2. Overall, 27 (20%) and 26 (20%) volunteers had ≥1 AE at least possibly related to darunavir and cobicistat, respectively. Conclusions Bioequivalence of the darunavir/cobicistat 800/150-mg FDC was demonstrated versus darunavir and cobicistat co-administered as single agents under fasted or fed conditions. Food increased darunavir exposure, therefore, darunavir/cobicistat should be administered with food.
Drawing to Remember: External Support of Older Adults’ Eyewitness Performance

Although healthy aging is accompanied by a general decline in memory functioning, environmental support at retrieval can improve older adults’ (+65 years) episodic remembering. Despite those over the age of 65years representing a growing proportion of the population, few environmental retrieval support methods have been empirically evaluated for use with older witnesses and victims of crime. Here, the efficacy of a novel retrieval technique, the Sketch Mental Reinstatement of Context, is compared with a standard Mental Reinstatement of Context and a no support control (Control). Fifty-one participants witnessed an unexpected live event, and 48 hours later were interviewed using one of three aforementioned techniques. In line with predictions emanating from cognitive theories of aging and the environmental support hypothesis, participants in the Sketch Mental Reinstatement of Context condition recalled significantly more correct information and fewer inaccurate items. The Sketch Mental Reinstatement of Context technique appears to scaffold memory retrieval in an age-appropriate manner during a post-event interview, possibly by encouraging more effortful retrieval and reducing dual-task load. As such, this procedure offers an effective alternative to current approaches, adding to the toolbox of techniques available to forensic and other interviewers.
Analysis of the Hydrodynamic Effects in a Surface Textured Circumferential Gas Seal

A theoretical finite-element model was developed to study the hydrodynamic effect of micro-pores generated by laser surface texturing (LST) in a circumferential gas seal. The seal is represented by two non-contacting annular surfaces of a rotating shaft and a stationary ring. The micro-pores of spherical segment shape are distributed uniformly over one of the annular surfaces. The hydrodynamic dimensionless pressure distribution in the uniform clearance between the annular surfaces is obtained from a solution of the Reynolds equation for compressible viscous gas in a laminar flow. Results of a parametric study along with a numerical example for a specific circumferential seal demonstrate a substantial hydrodynamic effect that can raise the opening average pressure in the seal clearance above the ambient one by up to 50 percent. Presented at the 56th Annual Meeting Orlando, Florida May 20–24, 2001
Flow and Temperature Fields Generated by a Thermally Activated Interventional Vascular Device

Flow and Temperature Fields Generated by a Thermally Activated Interventional Vascular Device. (August 2012) Casey David McCurrin, B.S., Texas A&M University Chair of Advisory Committee: Dr. Duncan J. Maitland Concern for the nonphysiologic energy required to actuate medical devices utilizing “smart material” properties of shape memory polymer (SMP) compels a rigorous investigation into the flow and temperature fields surrounding a thermally activated catheter device. Multiple analyses include the theoretical approaches of exact analytical solutions and finite difference modeling combined with the experimental techniques of particle image velocimetry (PIV) and laser-induced fluorescence (LIF). The attained velocities and temperatures related to the convective heat transfer impact the potential for blood or tissue damage caused by intravascular heating. The clinical scenario involving a catheter device receiving heat within an artery is modeled in its simplest form as a cylindrical metal cap on the tip of a hollow glass rod placed inside of a long straight tube of constant cross-sectional area. Using a working fluid with properties comparable to blood, flow rates and energy input is then varied to determine their effects on velocity fields and temperature gradients. Analytical solutions for both the straight tube and concentric annulus demonstrate the two velocity distributions involved, as flow moves past the gap between
Exploring Biological Surfaces by Nanoindentation

With the help of instrumented indentation, the mechanical behavior of a variety of biological systems was studied: the waxy zone of the pitcher plant ( Nephenthes alata ) adapted for attachment prevention, the head-to-thorax articulation system of a beetle ( Pachnoda marginata ) as an example of friction minimization, and the wing arresting system of the dung beetle ( Geotrupes stercorarius ) adapted for mechanical interlocking. We demonstrate that nanoindentation can successfully be applied to compliant and highly structured biological composite materials. Measuring the mechanical performance of these surfaces can provide important information for understanding the overall functioning of these systems. Tests on fresh and dried samples show the influence of desiccation on the results and point out the importance of native conditions during the measurements. However, these preliminary results also point to current limits of the test method and the need for adapting it and current theories to meet the specific requirements of biological materials.
Long-term Immune Response to Yellow Fever Vaccination in Human Immunodeficiency Virus (HIV)–Infected Individuals Depends on HIV RNA Suppression Status: Implications for Vaccination Schedule

Background In human immunodeficiency virus (HIV)-infected individuals, the immune response over time to yellow fever vaccination (YFV) and the necessity for booster vaccination are not well understood. Methods We studied 247 participants of the Swiss HIV Cohort Study (SHCS) with a first YFV after HIV diagnosis and determined their immune responses at 1 year, 5 years, and 10 years postvaccination by yellow fever plaque reduction neutralization titers (PRNTs) in stored blood samples. A PRNT of 1:≥10 was regarded as reactive and protective. Predictors of vaccination response were analyzed with Poisson regression. Results At vaccination, 82% of the vaccinees were taking combination antiretroviral therapy (cART), 83% had suppressed HIV RNA levels (<400 copies/mL), and their median CD4 T-cell count was 536 cells/μL. PRNT was reactive in 46% (95% confidence interval [CI], 38%-53%) before, 95% (95% CI, 91%-98%) within 1 year, 86% (95% CI, 79%-92%) at 5 years, and 75% (95% CI, 62%-85%) at 10 years postvaccination. In those with suppressed plasma HIV RNA at YFV, the proportion with reactive PRNTs remained high: 99% (95% CI, 95%-99.8%) within 1 year, 99% (95% CI, 92%-100%) at 5 years, and 100% (95% CI, 86%-100%) at 10 years. Conclusions HIV-infected patients' long-term immune response up to 10 years to YFV is primarily dependent on the control of HIV replication at the time of vaccination. For those on successful cART, immune response up to 10 years is comparable to that of non-HIV-infected adults. We recommend a single YFV booster after 10 years for patients vaccinated on successful cART, whereas those vaccinated with uncontrolled HIV RNA may need an early booster.
Measurement of the Young’s modulus and shear modulus of extruded polystyrene foam by the longitudinal and flexural vibration methods

The Young’s modulus and shear modulus of extruded polystyrene foam were obtained by measurements using the longitudinal and flexural vibration methods on specimens with various lengths and performing a subsequent numerical analysis on the test data. In addition to the vibration tests, ISO 844 compression and ASTM C273/C273M-11 shear tests were conducted, and the results were compared with those obtained from the vibration tests. The Young’s modulus values could be measured accurately by the longitudinal and flexural vibration tests while reducing the effects of the specimen configuration. In contrast, the shear modulus value was often dependent on the specimen configuration. The Young’s modulus and shear modulus values obtained from the vibration tests were often higher than those obtained from the standardised tests because the bending of cell wall is not induced in the vibration test. Although a provisional method for reducing the influence of the specimen configuration was proposed based on the numerical results, further research is required to measure the elastic modulus of extruded polystyrene foam accurately.
Maternal Dietary Diversity and Growth of Children Under 24 Months of Age in Rural Dodoma, Tanzania

Objective: To identify predictors of maternal dietary diversity in rural Dodoma, Tanzania and assess its association with child growth outcomes. Methods: A cross-sectional survey of 361 mothers with children under 24 months of age was conducted in 5 villages in rural Dodoma, Tanzania. Maternal diets were assessed using food frequency questionnaires, and dietary diversity was categorized using Minimum Dietary Diversity for Women (MDD-W) guidelines. Child anthropometric measures were taken to calculate height-for-age z-score (HAZ), weight-for-height z-score (WHZ), and weight-for-age z-score (WAZ). Linear and logistic regressions were used to examine the association between maternal dietary diversity and children’s growth outcomes. Results: About 40% of mothers did not consume a diverse diet (MDD-W < 5), and 35% of children were stunted. Household production of greater number of crops was associated with greater MDD-W scores (P < .01). Greater maternal dietary diversity was associated with significantly greater child WHZ (mean difference = 0.44; 95% confidence interval [CI]: 0.10-0.78; P = .01), WAZ (mean difference = 0.37; 95% CI: 0.08-0.65; P = .01), and reduced risk of wasting (odds ratio = 0.22; 95% CI: 0.07-0.66; P = .01). Conclusions: Greater maternal dietary diversity was associated with improved child WHZ and WAZ outcomes. Sustainable interventions to increase maternal dietary diversity may improve WHZ and WAZ in young children in similar settings.
Recent divergences in stratospheric water vapor measurements by frost point hygrometers and the Aura Microwave Limb Sounder

Balloon-borne frost point hygrometers (FPs) and the Aura Microwave Limb Sounder (MLS) provide high-quality vertical profile measurements of water vapor in the upper troposphere and lower stratosphere (UTLS). A previous comparison of stratospheric water vapor measurements by FPs and MLS over three sites - Boulder, Colorado (40.0° N); Hilo, Hawaii (19.7° N); and Lauder, New Zealand (45.0° S) - from August 2004 through December 2012 not only demonstrated agreement better than 1% between 68 and 26 hPa but also exposed statistically significant biases of 2 to 10% at 83 and 100 hPa (Hurst et al., 2014). A simple linear regression analysis of the FP-MLS differences revealed no significant long-term drifts between the two instruments. Here we extend the drift comparison to mid-2015 and add two FP sites - Lindenberg, Germany (52.2° N), and San José, Costa Rica (10.0° N) - that employ FPs of different manufacture and calibration for their water vapor soundings. The extended comparison period reveals that stratospheric FP and MLS measurements over four of the five sites have diverged at rates of 0.03 to 0.07 ppmv year−1 (0.6 to 1.5% year−1) from ~2010 to mid-2015. These rates are similar in magnitude to the 30-year (1980–2010) average growth rate of stratospheric water vapor (~ 1% year−1) measured by FPs over Boulder (Hurst et al., 2011). By mid-2015, the FP–MLS differences at some sites were large enough to exceed the combined accuracy estimates of the FP and MLS measurements.
Self-initiated spatial working memory in young and older adults

ABSTRACT The age-related decline in working memory (WM) has been studied extensively. Yet, research has focused mainly on one aspect of memory, in which older adults memorised information provided to them, neglecting the frequent everyday behaviour in which memory is self-initiated (SI), meaning that individuals memorise information they selected themselves. The present study used a modified spatial span task in which young and older adults memorised spatial sequences they constructed themselves, or random sequences provided to them. The results revealed that young and older adults carefully planned and constructed structured spatial sequences, by minimising distances between successive locations, and by selecting sequences with fewer path crossings and with more linear shapes. Older adults constructed sequences that were even more structured in some aspects. Young and older adults benefited from self-initiation to the same extent, showing similar age-related declines in SI and provided spatial WM. Overall, the study shows that older adults have access to metacognitive knowledge on the structure of efficient WM representations that benefit accuracy, and shows that older adults can use strategic encoding processes efficiently when encoding is SI. More generally, SI WM explores an important aspect of behaviour, demonstrating how older adults shape their environment to facilitate cognitive functioning.
RED CELLS , IRON , AND ERYTHROPOIESIS Hemopexin therapy reverts heme-induced proin fl ammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit, Heidelberg University & European Molecular Biology Laboratory, Heidelberg, Germany; Molecular Biotechnology Center & Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy; Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal; Innate Immunity Group, German Cancer Research Center, Heidelberg, Germany; CSL Behring, Research & Development, Kankakee, IL; and CSL Behring, Research & Development, Bern, Switzerland
Study on Mechanical Properties of Single-Crystal Silicon Carbide by Nanoindentation

In order to clarify the mechanical properties of single-crystal silicon carbide (SiC), nanoindentation was performed on a 4H-SiC wafer. The change of hardness with the angle between the wafer orientation flat and the indenter edge, the maximum load and the loading rate were investigated. The hardness reached maximum at an indentation load of 12 mN in the range of 3-50 mN. Hardness decreased under two conditions: when the edge of the indenter tip is parallel to the [11-20] direction, and when a very low loading rate was used. Transmission electron microscopy was used to observe dislocations and cracks under the indents. It was demonstrated that the deformation process of SiC involved three steps with respect to the increase of the indentation load. These results provide information for improving ductile machining process of single crystal SiC.
Whole-Genome Resequencing Identifies the Molecular Genetic Cause for the Absence of a Gy5 Glycinin Protein in Soybean PI 603408

During ongoing proteomic analysis of the soybean (Glycine max (L.) Merr) germplasm collection, PI 603408 was identified as a landrace whose seeds lack accumulation of one of the major seed storage glycinin protein subunits. Whole genomic resequencing was used to identify a two-base deletion affecting glycinin 5. The newly discovered deletion was confirmed to be causative through immunological, genetic, and proteomic analysis, and no significant differences in total seed protein content were found to be due to the glycinin 5 loss-of-function mutation per se. In addition to focused studies on this one specific glycinin subunit-encoding gene, a total of 1,858,185 nucleotide variants were identified, of which 39,344 were predicted to affect protein coding regions. In order to semiautomate analysis of a large number of soybean gene variants, a new SIFT 4G (Sorting Intolerant From Tolerated 4 Genomes) database was designed to predict the impact of nonsynonymous single nucleotide soybean gene variants, potentially enabling more rapid analysis of soybean resequencing data in the future.
[Association Between Sleep Patterns and Diurnal Blood Pressure Variation and Its Predictors in Women With Systemic Lupus Erythematosus].

BACKGROUND Sleep disturbances and hypertension are common health issues in patients with systemic lupus erythematosus (SLE). Limited information is available regarding the objective sleep quality and the variation of diurnal blood pressure (BP) in patients with SLE. Moreover, the relationship between sleep patterns and diurnal BP variation in SLE patients is not clear. PURPOSE To explore the subjective/objective sleep patterns and the diurnal BP variation in women with SLE, to identify the factors associated with diurnal BP variation, and to identify the predictors of this variation. METHODS A cross-sectional, descriptive, correlational study was conducted and 42 women with SLE were recruited. Participants completed the Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale, and Brief Pain Inventory. Rheumatologists rated current lupus disease activity. Additionally, the participants wore a wrist actigraph for 7 consecutive days and underwent 24h ambulatory BP monitoring for one day. RESULTS The mean Global PSQI score was 7.74 ± 3.21; 69% of the participants reported poor subjective sleep quality; the actigraphy-measured sleep efficiency was 85.29 ± 5.95%; and 42.9% had poor objective sleep quality. Total sleep time at night was positively associated with diurnal change in diastolic BP (r = .315. p < .05) and pain severity was negatively associated with diurnal change in systolic BP (r = -.430, p < .01) and diastolic BP (r = -.371, p < .05). Multiple linear regression analysis was used to predict diurnal BP variation. Moreover, pain was a significant predictor of diurnal change in systolic BP (β = -0.397, p < .01) and diurnal change in diastolic BP (β = -0.325, p < .05). CONCLUSIONS / IMPLICATIONS FOR PRACTICE The findings of the present study suggest that healthcare professionals should routinely evaluate sleep quality and pain in SLE patients. Improving both the poor sleep and pain management of these patients is clinically important. Further studies of the association between pain management and diurnal BP variation are needed.
Assessing root death and root system dynamics in a study of grape canopy pruning.

summary Defining root death in studies of root dynamics is problematic because cell death occurs gradually and the resulting eects on root function are not well understood. In this study, metabolic activity of grape roots of dierent ages was assessed by excised root respiration and tetrazolium chloride reduction. We investigated changes in metabolic activity and patterns of cell death occurring with root age and changes in root pigmentation. Tetrazolium chloride reduction of roots of dierent ages was strongly correlated to respiration (R# fl 0.786). As roots aged, respiration and tetrazolium chloride reduction declined similarly, with minimum metabolic activity reached at six weeks. Tetrazolium chloride reduction indicated that the onset of root browning corresponded to a 77% reduction in metabolic activity (P! 0.001). Anatomical examination of roots at each pigmentation stage showed that even though some cells in brown roots were still alive, these roots were functionally dead. The eect of using dierent definitions of root death in relation to root survivorship was determined in a study of ‘Concord’ grapes with two pruning treatments, using three criteria for root death: browning, blackening or shriveling, and disappearance. There was no eect of vine pruning on root life span when life span was defined as the time from first appearance to the onset of browning. However, if death was judged as the point when roots either became black or shriveled or disappeared, vine pruning decreased root life span by 34% and 40%, respectively (P! 0.001), and also increased the decay constant for root decomposition by about 45% (P! 0.001). We conclude that the discrepancy among determinations of root life span assessed with dierent definitions of death might be partly caused by the latter evaluations of root life span incorporating a portion of root decomposition in definitions of root death.
Toward the Integration of CV Quantum Key Distribution in Deployed Optical Networks

In this letter, we report on the advances toward the integration of our developed continuous variables (CV) quantum key distribution (QKD) system in existing optical infrastructure and wavelength division multiplexed (WDM) networks. First, we investigate the tolerance of the CV-QKD system to spontaneous Raman scattering (SRS) noise, the latter being the most dominant impairment in a WDM co-existence environment for QKD. In particular, we investigate by experiment the impact of a WDM $10\times 10$ Gb/s ON–OFF-keying signal in terms of induced SRS noise in the QKD channel. The spontaneous SRS noise influence is assessed for different transmission scenarios, i.e., for various optical launch powers of the WDM signal, and for different transmission links of 20, 40, 60, and 80 km. Based on the experimental data and on the measured system’s parameters, we estimate the key rates and reach capabilities of the proposed CV-QKD system. The scheme supports a key rate of 90 kbit/s over 20 km, for an ideal QKD system multiplexed with 2-mW optical power. A step further, we demonstrate for first time the use of the aforementioned CV-QKD system to encrypt a 10GE client service over deployable optical transport network legacy equipment over 20 km. Our results prove the feasibility of the integration of our proposed scheme with legacy telecom equipment in existing WDM optical networks.