Miracle-dz/UniFAR-FTUs huggingface dataset:
Physician Perceptions and Beliefs about Generating and Providing a Clinical Summary of the Office Visit

Summary Background: A core measure of the meaningful use of EHR incentive program is the generation and provision of the clinical summary of the office visit, or the after visit summary (AVS), to patients. However, little research has been conducted on physician perceptions and beliefs about the AVS. Objective: Evaluate physician perceptions and beliefs about the AVS and the effect of the AVS on workload, patient outcomes, and the care the physician delivers. Methods: A cross-sectional online survey of physicians at two academic medical centers (AMCs) in the northeast who are participating in the meaningful use EHR incentive program. Results: Of the 1 795 physicians at both AMCs participating in the incentive program, 853 completed the survey for a response rate of 47.5%. Eighty percent of the respondents reported that the AVS was easy (very easy or quite easy or somewhat easy) to generate and provide to patients. Nonetheless, more than three-fourths of the respondents reported a negative effect of generating and providing the AVS on workload of office staff (78%) and workload of physicians (76%). Primary care physicians had more positive beliefs about the effect of the AVS on patient outcomes than specialists (p<0.001) and also had more positive beliefs about the effect of the AVS on the care they delivered than specialists (p<0.001). Conclusions: Achieving the core meaningful use measure of generating and providing the AVS was easy for physicians but it did not necessarily translate into positive beliefs about the effect of the AVS on patient outcomes or the care the physician delivered. Physicians also had negative beliefs about the effect of the AVS on workload. To promote positive beliefs among physicians around the AVS, organizations should obtain physician input into the design and implementation of the AVS and develop strategies to mitigate its negative impacts on workload. Citation: Emani S, , Ting DY, Healey M, Lipsitz SR, Ramelson H, Suric V, Bates DW. Physician perceptions and beliefs about generating and providing a clinical summary of the office visit. Appl Clin Inform 2015; 6: 577–590 http://dx.doi. org/10.4338/ACI-2015-04-RA-0043
High-Cadence Observations of an Impulsive Flare

We analyzed high-cadence observations of a C5.7 flare on 1999 August 23 at Big Bear Solar Observatory (BBSO). The observing wavelength was 1.3 Å in the blue wing of Hα, with a cadence of 0.033 s. In addition, the hard X-ray's time profile obtained by the Burst And Transient Source Experiment (BATSE) and BBSO high-resolution magnetograms was compared with our Hα observations to understand in detail the particle precipitation in this event. The important results are as follows:
Further Improved Differential Fault Analysis on Camellia by Exploring Fault Width and Depth

In this paper, we present two further improved differential fault analysis methods on Camellia by exploring fault width and depth. Our first method broadens the fault width of previous Camellia attacks, injects multiple byte faults into the r round left register to recover multiple bytes of the r round equivalent key, and obtains Camellia-128,192/256 key with at least 8 and 12 faulty ciphertexts respectively; our second method extends fault depth of previous Camellia attacks, injects one byte fault into the r-2 round left register to recover full 8 bytes of the r round equivalent key, 5-6 bytes of the r-1 round equivalent key, 1 byte of the r-2 round equivalent key, and obtains Camellia-128,192/256 key with 4 and 6 faulty ciphertexts respectively. Simulation experiments demonstrate: due to its reversible permutation function, Camellia is vulnerable to multiple bytes fault attack, the attack efficiency is increased with fault width, this feature greatly improves fault attack’s practicalities; and due to its Feistel structure, Camellia is also vulnerable to deep single byte fault attack, 4 and 6 faulty ciphertexts are enough to reduce Camellia-128 and Camellia-192/256 key hypotheses to 2 and 2 respectively.
Impact of Plant Cover on Fitness and Behavioural Traits of Captive Red-Eyed Tree Frogs (Agalychnis callidryas)

Despite the importance of ex situ conservation programmes as highlighted in the Amphibian Conservation Action Plan, there are few empirical studies that examine the influence of captive conditions on the fitness of amphibians, even for basic components of enclosure design such as cover provision. Maintaining the fitness of captive amphibian populations is essential to the success of ex situ conservation projects. Here we examined the impact of plant cover on measures of fitness and behaviour in captive red-eyed tree frogs (Agalychnis callidryas). We found significant effects of plant provision on body size, growth rates and cutaneous bacterial communities that together demonstrate a compelling fitness benefit from cover provision. We also demonstrate a strong behavioural preference for planted rather than non-planted areas. We also assessed the impact of plant provision on the abiotic environment in the enclosure as a potential driver of these behavioural and fitness effects. Together this data provides valuable information regarding enclosure design for a non-model amphibian species and has implications for amphibian populations maintained in captivity for conservation breeding programmes and research.
Dust exposure and mortality in an American chrysotile asbestos friction products plant.

Cohort studies in three American asbestos factories were undertaken to investigate the effect of fibre type and manufacturing process on lung cancer, mesothelioma, and asbestosis. Reports have been published on a chrysotile textile plant in South Carolina and a mainly textile plant in Pennsylvania, which also used amphiboles. In the third plant in Connecticut friction products and packings were made from chrysotile only. In a cohort of 3641 men employed for one month or more, 1938-58, 3513 (96.5%) were traced, 1267 (36%) had died, and death certificates were obtained for 1228 (96.9%). Individual exposures were estimated (in mcpf . years) from impinger measurements. Life table analyses using Connecticut mortality rates gave an SMR for all causes of 108.5 (USA 107.9). The SMR (all causes) for men who had worked for less than a year was 129.9 and for those who had worked for a year or more, 101.2. The equivalent SMRs for respiratory cancer were 167.4 and 136.7 respectively. Excluding men who had worked for less than a year, there was possible evidence of some increase in risk of lung cancer with increasing exposure, supported also by a "log-rank" (case-control) analysis, of the same order as that observed in chrysotile mining and milling. These findings may be compared with chrysotile textile manufacture where the risk of lung cancer was some 50-fold greater. It is suggested that the differences in risk are perhaps related to the higher proportion of submicroscopic fibres in textile manufacture that may result from the traumatic carding , spinning, and weaving processes. No case of mesothelioma was found, consistent with a much lower risk of this tumour with chrysotile than with amphiboles. Twelve deaths (nine in men with very short and low asbestos exposure) were given ICD code 523 (pneumoconiosis); all but two were ascribed to anthracosilicosis or silicosis and none to asbestosis.
Role of Metabolic Genes in Blood Arsenic Concentrations of Jamaican Children with and without Autism Spectrum Disorder

Arsenic is a toxic metalloid with known adverse effects on human health. Glutathione-S-transferase (GST) genes, including GSTT1, GSTP1, and GSTM1, play a major role in detoxification and metabolism of xenobiotics. We investigated the association between GST genotypes and whole blood arsenic concentrations (BASC) in Jamaican children with and without autism spectrum disorder (ASD). We used data from 100 ASD cases and their 1:1 age- and sex-matched typically developing (TD) controls (age 2–8 years) from Jamaica. Using log-transformed BASC as the dependent variable in a General Linear Model, we observed a significant interaction between GSTP1 and ASD case status while controlling for several confounding variables. However, for GSTT1 and GSTM1 we did not observe any significant associations with BASC. Our findings indicate that TD children who had the Ile/Ile or Ile/Val genotype for GSTP1 had a significantly higher geometric mean BASC than those with genotype Val/Val (3.67 µg/L vs. 2.69 µg/L, p < 0.01). Although, among the ASD cases, this difference was not statistically significant, the direction of the observed difference was consistent with that of the TD control children. These findings suggest a possible role of GSTP1 in the detoxification of arsenic.
Why Do People Share Photos Online? Antecedents of Photos' Quality and Quantity

Content contribution from individuals is critical to the viability of online communities. In this study we identify the factors that are associated with the quantity and the quality of content sharing in a photo sharing community, where the act of content creation is decoupled from the act of content sharing. We draw on theories of intrinsic and extrinsic motivation, and find that the prospect of expected rewards is positively related to the quality of the content shared, but negatively related to the quantity of it. Enjoyment of content creation is related to the quantity of the photos shared, whereas enjoyment of content sharing (posting the photos) is significantly related to the quality of the photos shared. In addition, we find that commitment to the community is negatively related to the quality of the content shared. Directions for further development, as well as implications for theory and practice are discussed.
How to work with a subgroup analysis.

Surgical practice should principally be based on evidence originating from high-quality data such as randomized controlled trials (RCTs). Whereas these studies mostly investigate general and representative patient populations, clinical decisions most often depend on individual patient characteristics. To concede to the need of individually based guidelines, many RCTs report analyses on specific subgroups of patients.1,2 The main aim of a subgroup analysis is to identify either consistency of or large differences in the magnitude of treatment effect among different categories of patients. Determining whether the observed overall treatment effect is different across certain subgroups may justly provide some patients with its benefits and protect others from its harm. Irrespective of its practical potentials, subgroup analysis must be conscientious in design, reporting and interpretation. Many stringent methodological criteria apply but are far from always fulfilled.2 Consequently, inferences drawn may wrongfully direct management of certain patient groups. In fact, the definition of a subgroup analysis is equivocal in that authors use the term to indicate tests that estimate differences in treatment effect within subgroups (a subgroup effect) and between subgroups (an interaction; Table 1). Table 1 Conceptual difference between within- and between-subgroup tests The purpose of this article is to consider criteria for sound subgroup analyses in RCTs, assuming good underlying methodological quality of the main trial (i.e., randomization, assessor blinding, etc.). 3 A clinical scenario, based on a recent RCT in orthopedic surgery, will practically support the theoretical statements throughout the text.
Comparing Graph Representations of Protein Structure for Mining Family-Specific Residue-Based Packing Motifs

We find recurring amino-acid residue packing patterns, or spatial motifs, that are characteristic of protein structural families, by applying a novel frequent subgraph mining algorithm to graph representations of protein three-dimensional structure. Graph nodes represent amino acids, and edges are chosen in one of three ways: first, using a threshold for contact distance between residues; second, using Delaunay tessellation; and third, using the recently developed almost-Delaunay edges. For a set of graphs representing a protein family from the Structural Classification of Proteins (SCOP) database, subgraph mining typically identifies several hundred common subgraphs corresponding to spatial motifs that are frequently found in proteins in the family but rarely found outside of it. We find that some of the large motifs map onto known functional regions in two protein families explored in this study, i.e., serine proteases and kinases. We find that graphs based on almost-Delaunay edges significantly reduce the number of edges in the graph representation and hence present computational advantage, yet the patterns extracted from such graphs have a biological interpretation approximately equivalent to that of those extracted from distance based graphs.
Speed and direction response profiles of neurons in macaque MT and MST show modest constraint line tuning

Several models of heading detection during smooth pursuit rely on the assumption of local constraint line tuning to exist in large scale motion detection templates. A motion detector that exhibits pure constraint line tuning responds maximally to any 2D-velocity in the set of vectors that can be decomposed into the central, or classic, preferred velocity (the shortest vector that still yields the maximum response) and any vector orthogonal to that. To test this assumption, we measured the firing rates of isolated middle temporal (MT) and medial superior temporal (MST) neurons to random dot stimuli moving in a range of directions and speeds. We found that as a function of 2D velocity, the pooled responses were best fit with a 2D Gaussian profile with a factor of elongation, orthogonal to the central preferred velocity, of roughly 1.5 for MST and 1.7 for MT. This means that MT and MST cells are more sharply tuned for speed than they are for direction; and that they indeed show some level of constraint line tuning. However, we argue that the observed elongation is insufficient to achieve behavioral heading discrimination accuracy on the order of 1–2 degrees as reported before.
Global Assimilation of Loon Stratospheric Balloon Observations

Accurate analyses of stratospheric winds are important for determining realistic constituent transport and providing improved diagnostic studies and forecasts of the stratosphere. This study examines impacts on global meteorological analyses resulting from using winds derived from Loon superpressure balloons in the lower stratosphere (hereafter Loon winds) as additional input observations to the Goddard Earth Observing System (GEOS) data assimilation system. To fully investigate the impacts of assimilating the Loon winds, two steps are taken: (1) comparison of the GEOS analysis winds with Loon winds (Control experiment) and (2) examination of the impacts of assimilating the Loon winds into the GEOS data assimilation system (Loon experiment). The time period selected is June–August 2014 when over 150 Loon balloons were launched, mainly in the Southern Hemisphere. In the middle latitudes, the Loon winds and Control winds agree well (Loon balloon zonal wind observation minus forecast, O − F, root‐mean‐square (RMS) values of ~2.75 m/s) and assimilating the Loon winds has a small impact (O − F RMS values unchanged). In the tropics, the Loon observations and Control analysis winds differ more than in middle latitudes (zonal wind O − F RMS ~3.75 m/s) and assimilating the Loon winds improves the zonal wind O − F RMS by ~1 m/s. In selected cases where the Loon observations and Control analysis differ greatly (O − F RMS values greater than 10 m/s), assimilating Loon winds significantly decreases the zonal wind O − F RMS by 5 m/s. These decreases in O − F RMS values show that the 6‐hr forecasts are improved at the Loon balloon observation locations.
Comprehensive genetic analysis of OEIS complex reveals no evidence for a recurrent microdeletion or duplication

Omphalocele–exstrophy of the bladder‐imperforate anus‐spinal defects (OEIS) complex, or cloacal exstrophy (EC), is a rare constellation of malformations in humans involving the urogenital, gastrointestinal, and skeletal systems, and less commonly the central nervous system. Although OEIS complex is well‐recognized in the clinical setting, there remains a significant lack of understanding of this condition at both the developmental and the genetic level. While most cases are sporadic, familial cases have been reported, suggesting that one or more specific genes may play a significant role in this condition. Several developmental mechanisms have been proposed to explain the etiology of OEIS complex, and it is generally considered to be a defect early in caudal mesoderm development and ventral body wall closure. The goal of this study was to identify genetic aberrations in 13 patients with OEIS/EC using a combination of candidate gene analysis and microarray studies. Analysis of 14 candidate genes in combination with either high resolution SNP or oligonucleotide microarray did not reveal any disease‐causing mutations, although novel variants were identified in five patients. To our knowledge, this is the most comprehensive genetic analysis of patients with OEIS complex to date. We conclude that OEIS is a complex disorder from an etiological perspective, likely involving a combination of genetic and environmental predispositions. Based on our data, OEIS complex is unlikely to be caused by a recurrent chromosomal aberration. © 2010 Wiley‐Liss, Inc.
Identification of an Archaeal Type II Isopentenyl Diphosphate Isomerase in Methanothermobacter thermautotrophicus

ABSTRACT Isopentenyl diphosphate (IPP):dimethylallyl diphosphate isomerase catalyzes the interconversion of the fundamental five-carbon homoallylic and allylic diphosphate building blocks required for biosynthesis of isoprenoid compounds. Two different isomerases have been reported. The type I enzyme, first characterized in the late 1950s, is widely distributed in eukaryota and eubacteria. The type II enzyme was recently discovered in Streptomyces sp. strain CL190. Open reading frame 48 (ORF48) in the archaeon Methanothermobacter thermautotrophicus encodes a putative type II IPP isomerase. A plasmid-encoded copy of the ORF complemented IPP isomerase activity in vivo in Salmonella enterica serovar Typhimurium strain RMC29, which contains chromosomal knockouts in the genes for type I IPP isomerase (idi) and 1-deoxy-d-xylulose 5-phosphate (dxs). The dxs gene was interrupted with a synthetic operon containing the Saccharomyces cerevisiae genes erg8, erg12, and erg19 allowing for the conversion of mevalonic acid to IPP by the mevalonate pathway. His6-tagged M. thermautotrophicus type II IPP isomerase was produced in Escherichia coli and purified by Ni2+ chromatography. The purified protein was characterized by matrix-assisted laser desorption ionization mass spectrometry. The enzyme has optimal activity at 70°C and pH 6.5. NADPH, flavin mononucleotide, and Mg2+ are required cofactors. The steady-state kinetic constants for the archaeal type II IPP isomerase from M. thermautotrophicus are as follows: Km, 64 μM; specific activity, 0.476 μmol mg−1 min−1; and kcat, 1.6 s−1.
Frequency, causes, predictors, and clinical significance of peri-procedural myocardial infarction following percutaneous coronary intervention.

AIMS Peri-procedural myocardial infarction (MI) is a not infrequent complication of percutaneous coronary intervention (PCI), but conflicting information exists regarding incidence and prognostic impact of this event. We investigated frequency, causes, predictors, and clinical relevance of peri-procedural MI, using a large database. METHODS AND RESULTS We pooled individual patient-level data from 11 PCI studies in which peri-procedural creatine kinase-MB mass was routinely measured and mortality data were prospectively collected. Among 23 604 patients from 11 studies, 1677 {7.1% [95% confidence interval (CI) 6.8-7.5%]} had peri-procedural MI. The most common mechanism of peri-procedural MI was side-branch occlusion. Independent predictors of peri-procedural MI were older age, female gender, diabetes, hypertension, renal dysfunction, multivessel disease, left anterior descending artery disease, left main disease, bifurcation lesion, long lesion, drug-eluting stents, and number of stents. Follow-up varied from 1 year to 5 years. In a crude analysis, patients with peri-procedural MI had significantly a higher risk of mortality than those without peri-procedural MI [hazard ratio (HR) 1.47; 95% CI 1.24-1.74]. After adjustment for baseline covariates, peri-procedural MI was associated with an increased risk of mortality (HR 1.20; 95% CI 1.04-1.39). CONCLUSION Among patients undergoing PCI, the occurrence of peri-procedural MI measured by CK-MB mass assay was ~7%, and more than half of cases were associated with side-branch occlusion. Several higher risk patients, lesions, and procedural characteristics were independent predictors of peri-procedural MI. Peri-procedural MI was associated with an increase in mortality.
Improved Reliability of the NIH Stroke Scale Using Video Training

Despite the frequent use of clinical rating scales in multicenter therapeutic stroke trials, no generally acceptable method exists to train and certify investigators to use the instrument consistently. We desired to train investigators to use the National Institutes of Health Stroke Scale in a study of acute stroke therapy so that all examiners rated patients comparably. Methods We devised a two-camera videotape method that optimizes the visual presentation of examination findings. We then measured the effectiveness of the training by asking each investigator to evaluate a set of 11 patients, also on videotape. We tabulated the evaluations, devised a scoring system, and calculated measures of interobserver agreement among the participants in this study. Results We trained and certified 162 investigators. We found moderate to excellent agreement on most Stroke Scale items (unweighted K>0.60). TWO items, facial paresis and ataxia, exhibited poor agreement (unweighted K<0.40) and should be revised in future editions of the scale. Performance improved with video training compared with previous studies. Inclusion of the motor rating of the unaffected limbs in the total score did not affect reliability. Conclusions Video training and certification is a practical and effective method to standardize the use of examination scales. Two cameras must be used during the taping of patients to accurately present the clinical findings. This method is easily adapted to any study in which a large number of investigators will be enrolling patients at multiple clinical centers.