Miracle-dz/UniFAR-FTUs huggingface dataset:
Social Workers’ Orientation Toward the Evidence-Based Practice Process

Objectives: This study assesses social workers’ orientation toward the evidence-based practice (EBP) process and explores which specific variables (e.g. age) are associated. Methods: Data were collected from 341 Dutch social workers through an online survey which included a Dutch translation of the EBP Process Assessment Scale (EBPPAS), along with 13 background/demographic questions. Results: The overall level of orientation toward the EBP process is relatively low. Although respondents are slightly familiar with it and have slightly positive attitudes about it, their intentions to engage in it and their actual engagement are relatively low. Respondents who followed a course on the EBP process as a student are more oriented toward it than those who did not. Social workers under 29 are more familiar with the EBP process than those over 29. Conclusions: We recommend educators to take a more active role in teaching the EBP process to students and social workers.
Failure to utilize functions of an electronic prescribing system and the subsequent generation of 'technically preventable' computerized alerts

OBJECTIVES To determine the frequency with which computerized alerts occur and the proportion triggered as a result of prescribers not utilizing e-prescribing system functions. METHODS An audit of electronic inpatient medication charts at a teaching hospital in Sydney, Australia, was conducted to identify alerts fired, to categorize the system functions used by prescribers, and to assess if use of short-cut system functions could have prevented the alerts. RESULTS Of the 2209 active orders reviewed, 600 (27.2%) triggered at least one alert. Therapeutic duplication alerts were the most frequent (n=572). One third of these (20.2% of all alerts) was 'technically preventable' and would not have fired if prescribers had used a short-cut system function to prescribe. Under-utilized system functions included the option to 'MODIFY' existing orders and use of the 'AND' function for concurrent orders. Pregnancy alerts, set for women aged between 12 and 55 years, were triggered for 43% of drugs ordered for this group. CONCLUSION Developers of decision support systems should test the extent to which technically preventable alerts may arise when prescribers fail to use system functions as designed. Designs which aim to improve the efficiency of the prescribing process but which do not align with the cognitive processes of users may fail to achieve this desired outcome and produce unexpected consequences such as triggering unnecessary alerts and user frustration. Ongoing user training to support effective use of e-prescribing system functions and modifications to the mechanisms underlying alert generation are needed to ensure that prescribers are presented with fewer but more meaningful alerts.
On Clustered Graph Layouts Sketched by Users Based on Predefined Clusters

The aesthetics for user-sketched layouts of clustered graphs with known clustering information is analyzed empirically. In our experiments, given the adjacency list of a clustered graph and its predefined clustering information, each participant was asked to manually sketch clustered graphs "nicely" from scratch on a tablet system using a stylus. The main feature of this work different from the previous work is to investigate if the user's complex task of sketching clustered graphs "nicely" can be alleviated by providing the cluster partition information. Results show that most participants can draw graphs with clear presence of bridge edges and clustering cohesiveness.
Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue

OBJECTIVE Common variants in FTO (the fat mass– and obesity-associated gene) associate with obesity and type 2 diabetes. The regulation and biological function of FTO mRNA expression in target tissue is unknown. We investigated the genetic and nongenetic regulation of FTO mRNA in skeletal muscle and adipose tissue and their influence on in vivo glucose and fat metabolism. RESEARCH DESIGN AND METHODS The FTO rs9939609 polymorphism was genotyped in two twin cohorts: 1) 298 elderly twins aged 62–83 years with glucose tolerance ranging from normal to type 2 diabetes and 2) 196 young (25–32 years) and elderly (58–66 years) nondiabetic twins examined by a hyperinsulinemic-euglycemic clamp including indirect calorimetry. FTO mRNA expression was determined in subcutaneous adipose tissue (n = 226) and skeletal muscle biopsies (n = 158). RESULTS Heritability of FTO expression in both tissues was low, and FTO expression was not influenced by FTO rs9939609 genotype. FTO mRNA expression in skeletal muscle was regulated by age and sex, whereas age and BMI were predictors of adipose tissue FTO mRNA expression. FTO mRNA expression in adipose tissue was associated with an atherogenic lipid profile. In skeletal muscle, FTO mRNA expression was negatively associated to fat and positively to glucose oxidation rates as well as positively correlated with expression of genes involved in oxidative phosphorylation including PGC1α. CONCLUSIONS The heritability of FTO expression in adipose tissue and skeletal muscle is low and not influenced by obesity-associated FTO genotype. The age-dependent decline in FTO expression is associated with peripheral defects of glucose and fat metabolism.
Hypoglossal, trigeminal, and facial motoneuron involvement in amyotrophic lateral sclerosis

Facial, trigeminal, and hypoglossal motoneuron involvement was quantified in 25 amyotrophic lateral sclerosis patients and in normal controls. Measures included (1) maximum voluntary contraction of the lower lip, mandible, and tongue using custom-designed force transducers, (2) clinical functions of each muscle group, and in some patients (3) orofacial mobility using videofluoroscopy. All measures indicated that the tongue muscles were most severely affected, even in patients who initially had symptoms in the extremities.
Lidar and in situ observations of aerosols, radiation fluxes, and meteorological parameters during the 20 March 2015 solar eclipse over southern Italy

The effects of the 20 March 2015 partial solar eclipse on irradiance measurements, Planetary Boundary Layer (PBL) height, meteorological and turbulence parameters, and near surface particle properties have been investigated at Lecce (40.3°N, 18.1°E, 30 m a.s.l.), southeastern Italy. Each solar eclipse represents always a unique event, since it is characterized by a particular time of the day, season, location, and synoptic conditions, and allows investigating the atmospheric processes driven by a fast decrease of the solar radiation. According to the astronomic data, the eclipse started at the study site at about 08:30 UTC and ended at 10:47 UTC, reaching the maximum obscuration of the solar disk (43.6%) at about 09:37 UTC. Short-wave irradiance measurements revealed that the eclipse direct radiative forcing at the surface was equal to -307 W m-2 at the maximum obscuration of the solar disk. A lidar system operating at the study site within the European Aerosol LIdar NETwork (EARLINET) was used to investigate both the atmospheric turbulence weakening driven by the eclipse cooling effect and the PBL height time evolution. It has been found that the PBL height that was equal to 300 ± 30 m before the eclipse onset decreased up to 210 ± 20 m after the eclipse full phase. Measurements from a micrometeorological station have instead been used to investigate the atmospheric turbulence weakening at the ground level by the changes of turbulent kinetic energy. Integrating nephelometer measurements revealed that the solar eclipse was also responsible for the increase of the near surface particle scattering coefficient, mainly because of the increase of the fine-mode particle concentration.
Chemoprevention of Breast Cancer by Dietary Polyphenols

The review will discuss in detail the effects of polyphenols on breast cancer, including both the advantages and disadvantages of the applications of these natural compounds. First, we focus on the characterization of the main classes of polyphenols and then on in vitro and in vivo experiments carried out in breast cancer models. Since the therapeutic effects of the administration of a single type of polyphenol might be limited because of the reduced bioavailability of these drugs, investigations on combination of several polyphenols or polyphenols with conventional therapy will also be discussed. In addition, we present recent data focusing on clinical trials with polyphenols and new approaches with nanoparticles in breast cancer. Besides the clinical and translational findings this review systematically summarizes our current knowledge about the molecular mechanisms of anti-cancer effects of polyphenols, which are related to apoptosis, cell cycle regulation, plasma membrane receptors, signaling pathways and epigenetic mechanisms. At the same time the effects of polyphenols on primary tumor, metastasis and angiogenesis in breast cancer are discussed. The increasing enthusiasm regarding the combination of polyphenols and conventional therapy in breast cancer might lead to additional efforts to motivate further research in this field.
A Foreign Speech Accent in a Case of Conversion Disorder

Objective: The aim of this paper is to report the psychiatric, neuroradiological and linguistic characteristics in a native speaker of Dutch who developed speech symptoms which strongly resemble Foreign Accent Syndrome. Background: Foreign Accent Syndrome is a rare speech production disorder in which the speech of a patient is perceived as foreign by speakers of the same speech community. This syndrome is generally related to focal brain damage. Only in few reported cases the Foreign Accent Syndrome is assumed to be of psychogenic and/or psychotic origin. Method: In addition to clinical and neuroradiological examinations, an extensive test battery of standardized neuropsychological and neurolinguistic investigations was carried out. Two samples of the patient's spontaneous speech were analysed and compared to a 500,000-words reference corpus of 160 normal native speakers of Dutch. Results: The patient had a prominent French accent in her pronunciation of Dutch. This accent had persisted over the past eight years and has become progressively stronger. The foreign qualities of her speech did not only relate to pronunciation, but also to the lexicon, syntax and pragmatics. Structural as well as functional neuroimaging did not reveal evidence that could account for the behavioural symptoms. By contrast psychological investigations indicated conversion disorder. Conclusions: To the best of our knowledge this is the first reported case of a foreign accent like syndrome in conversion disorder.
Rethinking Governance: Empirical Lessons Challenge Orthodoxy

In this discussion draft, linking research findings with concrete operational challenges, we review key issues in worldwide governance, and present recent empirical evidence. Focusing on defining and unbundling key governance components, such as rule of law, voice and accountability, corruption control, and state capture, we then provide evidence which suggests a sobering picture: on average, there appears to be scant progress worldwide in recent times in improving rule of law and governance, in controlling corruption, and in improving institutional quality -- although there is clearly variance across countries. Further, recent empirical research points to the private sector as influencing public governance, thereby challenging traditional notions of the functioning of politicians, public policy and the public sector, and on the conventional determinants of the investment climate. We posit that the interplay between the elite’s vested interests and the political dynamics within a country, in turn affecting governance and corruption, has often been under-emphasized in program design. These argue for revisiting conventional approaches to promote institutional reform. In particular, we challenge the notion that passing laws by fiat, creating new public institutions, or embarking on anti-corruption 'campaigns', can be very effective, and question the value of traditional public sector management and conventional legal/judiciary reform approaches for many emerging economies. We argue instead that sharper focus on external accountability is required, focusing on: transparency mechanisms and empirically-based monitoring tools (including e*governance), as well as participatory 'voice' and incentive-driven approaches for prevention. These need to feature more prominently in providing checks and balances on traditional public institutions, in empowering non-traditional stakeholders, and in ameliorating state capture and mitigating the very ‘unequal influence' playing field in many countries. In turn, this necessitates probing deeper into the private-public governance nexus, which inter alia leads to focusing on concrete measures to address the challenges of political contestability, political financing reform, and transparency in parliaments, the judiciary and the executive. Recommendations on governance strategies for the next phase are suggested, including on the role of the international community.
The Healing of Our People: Substance Abuse and Historical Trauma

For the past two decades, one of the authors (Robert Morgan) has been involved in the development and implementation of culturally based outpatient, inpatient, and aftercare programs for Alaskan native and American-Indian populations in Alaska. After years of observation, it was concluded that the best efforts of our clinicians were inadequate to the task at hand, i.e., that of resolving the social and physical ills that have ravaged the Alaskan peoples since the occupation. Morgan and others sought to create a new model of diagnosis and treatment that combined the cultural strengths of the people with the technical and treatment skills of the conventional medical profession. The model was grounded in a clear understanding of the factors causing disease in the people, and that understanding came from the people themselves. Before the growth of the “healing plant” that Uncle Walter spoke of could be nurtured, it was necessary to first examine the question of cause and effect. Much of the cause is rooted in the “historical trauma” experienced by the Alaska Native People. The effects are numerous, but one of the most obvious symptoms is substance misuse.
A field‐based study of soil water and groundwater nitrate release in an Adirondack forested watershed

Nitrate (NO3−) movement was studied using a combination of isotopic, chemical, and hydrometric data within the 135 ha Archer Creek watershed in the Adirondack Mountains of New York from January 1995 to December 1996. This research was conducted to identify sources of stream water NO3− and the mechanisms that deliver NO3− to the stream to test two hypotheses: (1) Soil water NO3− concentrations are highest after dry periods and subsequently lower with each storm. (2) Stream water NO3− concentrations are controlled by groundwater during growing season low flows and by soil water during the dormant season and during storms. Antecedent moisture conditions and season had little effect on mean soil water NO3− concentrations before storms (range of 1.1–5.1 μmol L−1 throughout the study). High soil water NO3− concentrations (up to 136 μmol L−1) were found only at the watershed ridge top during the 1996 snowmelt and early summer. Results from isotopic hydrograph separations and chemical end‐member mixing analysis showed that soil water and till groundwater dominated stream base flow and storm flow during six monitored storms. Near‐stream wetland groundwater and event water contributed little to streamflow during most conditions. Near‐stream groundwater contributions to streamflow were significant only during very low base flow (<0.05 mm h−1) during the summer and fall. Highest stream water NO3− concentrations coincided with peaks in the till groundwater contribution according to isotopic hydrograph separations using δ18O and chloride as conservative tracers. A conceptualization of streamflow generation and watershed NO3− release is described in which hillslope hollows are the principal zones of soil water and till groundwater mixing in the watershed and till groundwater is the main source of stream water NO3− during both base flow and storms.
Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses

There is epidemiological evidence that patients with certain Central Nervous System (CNS) disorders have a lower than expected probability of developing some types of Cancer. We tested here the hypothesis that this inverse comorbidity is driven by molecular processes common to CNS disorders and Cancers, and that are deregulated in opposite directions. We conducted transcriptomic meta-analyses of three CNS disorders (Alzheimer's disease, Parkinson's disease and Schizophrenia) and three Cancer types (Lung, Prostate, Colorectal) previously described with inverse comorbidities. A significant overlap was observed between the genes upregulated in CNS disorders and downregulated in Cancers, as well as between the genes downregulated in CNS disorders and upregulated in Cancers. We also observed expression deregulations in opposite directions at the level of pathways. Our analysis points to specific genes and pathways, the upregulation of which could increase the incidence of CNS disorders and simultaneously lower the risk of developing Cancer, while the downregulation of another set of genes and pathways could contribute to a decrease in the incidence of CNS disorders while increasing the Cancer risk. These results reinforce the previously proposed involvement of the PIN1 gene, Wnt and P53 pathways, and reveal potential new candidates, in particular related with protein degradation processes.
Applications of fast triangulation simplification

We describe a new algorithm to compute the geometric intersection number between two curves, given as edge vectors on an ideal triangulation. Most importantly, this algorithm runs in polynomial time in the bit-size of the two edge vectors. In its simplest instances, this algorithm works by finding the minimal position of the two curves. We achieve this by phrasing the problem as a collection of linear programming problems. We describe how to reduce the more general case down to one of these simplest instances in polynomial time. This reduction relies on an algorithm by the first author to quickly switch to a new triangulation in which an edge vector is significantly smaller.
Global Color Saliency Preserving Decolorization

The process of transforming a color image with three channels to a single channel grayscale image is called decolorization, which will unavoidably accompany with the information loss. In this paper, we propose a method to obtain a grayscale image which best preserves the global saliency of the color image. First, we convert the color image to the YUV color space, which separates the luminance and chrominance channels, and conduct parametric linear mapping on Y,U,V channels, through selecting different parameters to get different candidate grayscale images. Then, we compute the global contrast based saliency maps of the color image and candidate grayscale images. Finally, we use the Normalized Cross-Correlation metric to select the grayscale image whose saliency map is the most similar to that of the color image as the wanted decolorization result. The experiment results show that our method retains part of the chrominance information, prevents the contrast degradation in the isoluminance colors, and the global saliency preserving purpose reduces the abrupt change or distortion around the edge areas.
Latitudinal patterns in human stature and sexual stature dimorphism

Background: There exists substantial variation in human stature and sexual stature dimorphism that has been attributed to both genetic and environmental variables. A few studies have previously investigated possible relationships between latitude and stature, building on the idea that variation in climate can influence body size (Bergmann's rule). This change in body size can in turn have influenced sexual stature dimorphism (in accordance with Rensch's rule). Aim: The present study investigated whether latitude is associated with variation in human mean stature and sexual stature dimorphism. Subjects and methods: Phylogenetic and non-phylogenetic analyses were conducted on a cross-cultural sample of 124 human populations. Results: The results indicate that both male and female mean stature increase with increasing distance from the equator. While sexual stature dimorphism also was positively related to latitude in the non-phylogenetic test, this relationship disappeared when using a phylogenetic comparative method. Evidence was also found for curved relationships between latitude and both male and female stature, as well as stature dimorphism, all indicating a maximum at around 40° from the equator. Conclusions: The results of the present study indicate that both male and female stature are weakly associated with latitude. It is possible that these relationships are evolved responses to variation in climate. No unequivocal conclusion could be drawn regarding a possible relationship between latitude and sexual stature dimorphism.
S2Logger: End-to-End Data Tracking Mechanism for Cloud Data Provenance

The inability to effectively track data in cloud computing environments is becoming one of the top concerns for cloud stakeholders. This inability is due to two main reasons. Firstly, the lack of data tracking tools built for clouds. Secondly, current logging mechanisms are only designed from a system-centric perspective. There is a need for data-centric logging techniques which can trace data activities (e.g. file creation, edition, duplication, transfers, deletions, etc.) within and across all cloud servers. This will effectively enable full transparency and accountability for data movements in the cloud. In this paper, we introduce S2Logger, a data event logging mechanism which captures, analyses and visualizes data events in the cloud from the data point of view. By linking together atomic data events captured at both file and block level, the resulting sequence of data events depicts the cloud data provenance records throughout the data lifecycle. With this information, we can then detect critical data-related cloud security problems such as malicious actions, data leakages and data policy violations by analysing the data provenance. S2Logger also enables us to address the gaps and inadequacies of existing system-centric security tools.
Disparities in Prevalence of Smoking and Smoking Cessation during Pregnancy: A Population-Based Study

Objective. To examine time trends in prevalence of smoking and smoking cessation during pregnancy by family income, maternal level of education, skin color, and age. Methods. We conducted three population-based surveys in 2007, 2010, and 2013 with newly delivered mothers living in the municipality of Rio Grande, Southern Brazil. Data were collected using questionnaires administered after delivery in all (two) maternity units in the city, at Dr. Miguel Riet Corrêa Júnior Hospital and at Santa Casa de Misericórdia. Time trends were analyzed using chi-square test for linear trend. Results. Data of 7,572 women showed that the prevalence of smoking before pregnancy decreased from 28% (26.2–29.7) in 2007 to 22% (20.8–24.0) in 2013 (P < 0.001). Prevalence of smoking during pregnancy decreased from 22% (20.4–23.7) in 2007 to 18% (16.6–19.5) in 2013 (P < 0.001). This reduction varied across income ranging from 17% (poorest) to 35% (richest) (P < 0.001). The lower the income, the higher the smoking prevalence during pregnancy. Smoking cessation was more prevalent among women of higher level of education and income. Conclusions. Smoking before and during pregnancy is still highly prevalent and the prevalence of cessation is low pointing to a need to strengthen actions targeting low-income, less educated, black pregnant women.