Miracle-dz/UniFAR-FTUs huggingface dataset:
Endometrial cells from women with endometriosis have increased adhesion and proliferative capacity in response to extracellular matrix components: towards a mechanistic model for endometriosis progression.

BACKGROUND Endometriosis, classified as the presence of endometrial cells in ectopic sites, is a debilitating disease causing pain and infertility in approximately 10% of women of reproductive age. It is associated with the aberrant expression of extracellular matrix (ECM) components and their receptors, integrins. METHODS We analysed the expression of integrins in stromal cells derived from peritoneal, ovarian and deeply infiltrating endometriotic lesions and from endometrium from women with and without endometriosis in vitro, using quantitative immunocytochemistry. The adhesive and proliferative capacity of each of the cell types in response to ECM components was assessed by in vitro assays of cell attachment and DNA synthesis. RESULTS We demonstrate that eutopic and ectopic endometrial stromal cells from women with endometriosis exhibit an aberrant integrin profile in vitro compared with stromal cells derived from healthy controls. In addition, the former display increased adhesion and proliferative capacity in response to specific ECM components. CONCLUSIONS We propose that the increased adhesive and proliferative potential of cells from endometriotic lesions may be a key feature in the pathogenesis of endometriosis. Furthermore, the elevated responsiveness of eutopic cells from women with endometriosis may contribute to the predisposition of some women to the disease.
Climate change and chromosomal inversions in Drosophila subobscura

In natural populations, the large changes in chromosomal structure occurring through chromosomal inversions show pronounced variations in frequency that often correspond to temporal and spatial climatic trends, which suggests that they may be employed to monitor the impact of global warming. Here we review and update the evidence on the association between chromosomal inversions and climate in D. subobscura, which provides one of the best studied models in this con- text. Chromosomal inversion frequencies of D. subobscura populations vary predictably with lati- tude, and this association has evolved independently in Europe and South and North America. They also exhibit clear seasonal trends that are consistent with temperature fluctuations. More importantly, latitudinal clines in chromosomal inversion frequencies seem to be responding to the global rise in mean temperatures in all continents. We analyze the relevance of these results in the light of climate change, and discuss how a better understanding of the mechanisms underlying these patterns may contribute to our knowledge on the impacts of global warming in biological systems.
Z-TOPSIS approach for performance assessment using fuzzy similarity

This paper presents fuzzy similarity based Fuzzy Technique for Order Performance by Similarity to Ideal Solution (TOPSIS) for z-numbers. The classical fuzzy TOPSIS techniques use closeness coefficient to determine the rank order by calculating Fuzzy Positive Ideal Solution (FPIS) and Fuzzy Negative Ideal Solution (FNIS) simultaneously. The authors propose fuzzy similarity to replace closeness coefficient by doing ranking evaluation. Fuzzy similarity is used to calculate the similarity between two fuzzy ratings (FPIS and FNIS). Fuzziness is not sufficient enough when dealing with real information and a degree of reliability of the information is very critical. Hence, the implementation of z-numbers is taken into consideration as they can capture better the knowledge of human being and are extensively used in uncertain information development to deal with linguistic decision making problems. A numerical example is given to illustrate the application of the proposed technique in ranking company performance assessment. The results show that it is highly feasible to use the proposed technique in performance assessment.
Clinicopathologic Features of B-Cell Lineage Neoplasms With Aberrant Expression of CD3: A Study of 21 Cases

CD3 expression by immunohistochemistry was historically considered restricted to T-lineage or NK-lineage neoplasms but recently has been reported in rare cases of mature B-cell neoplasms, frequently in association with Epstein-Barr virus. Here, we describe the pathologic features of 21 B-cell lineage neoplasms that express CD3 protein by immunohistochemistry: 12 diffuse large B-cell lymphomas (DLBCLs); 2 plasmablastic lymphomas (PBLs); 4 plasma cell neoplasms; 2 Burkitt lymphomas; and 1 nodal follicular lymphoma, grade 3A. CD20 expression was negative or only partially positive in 13/21 cases. Epstein-Barr virus was positive in 3/20 tested cases (2 PBLs and 1 DLBCL). All tested neoplasms (14/14) had clonal immunoglobulin gene rearrangements, and no clonal T-cell gene rearrangements were detected (0/14). The 12 DLBCLs segregated into 2 main groups: 7 demonstrated features of plasmacytic differentiation but did not meet criteria for PBL, and 5 had anaplastic features. In addition to morphology, other features shared among the DLBCLs with plasmacytic differentiation, the plasma cell neoplasms, and the PBLs included extranodal presentation, cytoplasmic localization of CD3, and lack of expression of other T-cell antigens in most cases. In contrast, DLBCLs with anaplastic features and the single follicular lymphoma coexpressed multiple T-cell antigens in a predominantly membranous pattern and presented with nodal disease in a relatively younger patient population. Our data expand the spectrum of morphologic, phenotypic, and clinical features of B-cell neoplasms aberrantly expressing CD3. As these neoplasms often lack typical expression of B-cell antigens, knowledge of these features will help avoid misclassification.
Why Did House Members Vote for H.R. 4437? 1

This article examines why members of the U.S. House of Representatives voted for H.R. 4437, the controversial 2005 bill to construct a 700-mile immigration barrier along the U.S.-Mexican border and to criminalize illegal presence and aid to undocumented immigrants. Logit analysis suggests that being a first-term House member or a Republican and representing a district that was in the South or the West or heavily blue-collar substantially boosted the odds of supporting H.R. 4437. If a member's district was disproportionately Asian, Latino, or, especially, African American, he or she was instead more likely to oppose the measure.
The contribution of the psychosocial work environment to sickness absence in human service workers: Results of a 3-year follow-up study

Abstract We investigated to what extent psychosocial work characteristics predict sickness absence in a cohort of 890 human service professionals (84% women), followed-up for 3 years. We measured 16 different psychosocial work characteristics at baseline and analysed their associations with number of sickness absence days at follow-up using multivariate Poisson regression. In addition, we computed a psychosocial work environment index, summarizing eight psychosocial scales. Participants with exposure to violence and threats, high emotional demands, high demands for hiding emotions, low influence at work, low meaning of work, low quality of management, and role conflicts had an increased number of sickness absence days at follow-up, after adjustment for numerous confounders. Adjusting for sickness absence history caused little change in most effect estimates. Scoring in the most adverse quartile of the psychosocial work environment index was associated with a 71% increase in sickness absence days. Improving the psychosocial work environment index and eliminating exposure to violence and threats would have prevented 32% of all sickness absence days in the study population. In particular we found that exposure to violence was a strong predictor of absence. This study shows that a wide range of psychosocial work characteristics contribute to sickness absence in human service workers. Improving the psychosocial work environment might help to reduce sickness absence in this population.
Party Rules, OK: Voting in the House of Commons on the Human Fertilisation and Embryology Bill

The Human Fertilisation and Embryology Bill, which passed through the Westminster Parliament in 2007-08, demonstrated the dominance of party, even when the whips are removed and MPs are given a free vote. The party composition of the Commons determined the passage of the Bill and there is evidence that on abortion the dominance of party is becoming stronger still. There was also a gendered dimension to the voting, but even on abortion-the archetypical women's issue-the gender dimension came a poor second to the strength of party in determining the outcome of the vote.
Dodecylphosphocholine Micelles Induce Amyloid Formation of the PrP(110-136) Peptide via an α-Helical Metastable Conformation

A peptide encompassing the conserved hydrophobic region and the first β-strand of the prion protein (PrP(110–136)) shown to interact with the surface of dodecylphosphocholine micelles adopts an α-helical conformation that is localized below the head-group layer. This surface-bound peptide has a half-life of one day, and readily initiates the formation of amyloid fibrils. The presence of the latter was confirmed using birefringence microscopy upon Congo red binding and thioflavin T-binding induced fluorescence. The observation of this metastable α-helical conformer provides a unique snapshot of the early steps of the inter-conversion pathway. These findings together with the body of evidence from the prion literature allowed us to propose a mechanism for the conversion of PrPC to amyloid material.
Development of individual differences in reading : Results from longitudinal studies in english and finnish

The authors examined individual differences in reading development in English and Finnish. English-speaking Canadian children were assessed once per year in Grades 1-5, and Finnish children were assessed twice per year in Grades 1-2. Results from latent growth curve and simplex analyses showed that initial status was generally negatively associated with subsequent growth and that, although stable, individual differences were more likely to significantly decrease than to increase across the measurement points. Growth mixture models identified multiple groups of children whose reading development followed distinct patterns. The results indicate that it is possible for educational systems to significantly reduce individual differences in basic reading skills during early reading development.
A Spectral Line Study of Serpens S68 FIRS1 Region

A λ = 1 mm to 3 mm study of the Serpens molecular cloud core on scales of 10' to 10'' is presented, concentrating on the northwest condensation and the embedded sources, S68 FIRS1 and S68 N. We adopt temperatures of 25 K for the extended structure (several arcminute scale) and 35 K for the embedded sources. With these values, we use molecular line ratios and LVG statistical equilibrium calculations to derive physical properties in the region. We obtain densities between 0.4-1.2 × 106 cm-3 and an overall mass of 250-300 M☉. The majority of the mass is found in extended cloud material with two peaks of 30-45 M☉ each. Values of the molecular column densities are derived on scales of 60''-75'' (condensation) and 25''-30'' (embedded sources). The column densities in the condensation are typically as high as in the embedded sources, despite a factor of 4-5 in beam area, though there is some suggestion of mild depletions on smaller scales based on interferometric observations. Derived abundances for the region show similarities to both warmer cores and colder, dark cloud regions, with some values and ratios falling cleanly between this range of properties. Measurements of several deuterated species indicate enhanced abundances, suggesting the recent evaporation of grain mantles. Overall, the combined properties and measured abundances suggest an intermediate state between the extremes of dark clouds and evolved warm cores like Orion KL. In general, the Serpens NW condensation appears very similar to the IRAS 16293-2422 region, which is itself an example of a cool, low-mass star-forming region with chemical tracers characteristic of hotter, higher mass regions. Our results support the suggestion that the general chemical morphology of a region is determined more by the age of the region than by its mass.
Alignment und Aushandlung im Dialog

Zusammenfassung. Im Dialog sind zwei unterschiedliche Koordinationsarten zu beobachten, namlich das explizite Aushandeln und das implizite Alignment, das keiner bewussten Steuerung oder Kontrolle unterliegt. In jungster Zeit ist der Alignment-Begriff - angeregt durch die Studie von Pickering und Garrod (2004) - verstarkt in der Psycholinguistik diskutiert worden. Es kann gezeigt werden, dass zwar das Phanomen bereits fruher in der Psycholinguistik partiell von Buhler (1934), Hormann (1976) und Herrmann (1982, 1985) beschrieben worden ist, dass aber erst durch die derzeitige Diskussion die Tragweite von Alignmentprozessen erkannt wird. Der vorliegende Beitrag versucht, im Rahmen dieser Diskussion einige Forschungsperspektiven aufzuzeigen.
Territoriality Among Human Foragers: Ecological Models and an Application to Four Bushman Groups [and Comments and Reply]

Cost-benefit models derived from evolutionary ecology have led to the general expectation that territoriality will be found where resources are most abundant and predictable. Literature sources for four Bushman groups, however, indicate that the most territorial of these groups are found where resources are sparsest and most variable. This paper has as its aim the extension of the animal models of territoriality to make them more widely applicable to human foragers. The Bushmen control access to territorial resources in ways not found in other animals, and it is argued that these differences in the means of territorial defense may alter the expected relationships between environmental variables and territorial costs and benefits. The seemingly anomalous findings concerning Bushman territoriality are shown to be consistemt with cost-benefit theory only when this and other factors are taken into a account.
Health care professionals’ views of paediatric outpatient non-attendance: implications for general practice

Background. Non-attendance at paediatric hospital outpatient appointments poses potential risks to children’s health and welfare. Prevention and management of missed appointments depends on the perceptions of clinicians and decision makers from both primary and secondary care, including general practitioners (GPs) who are integral to non-attendance follow-up. Objectives. To examine the views of clinical, managerial and executive health care staff regarding occurrence and management of non-attendance at general paediatric outpatient clinics. Methods. A qualitative study using individual semi-structured interviews was carried out at three English Primary Care Trusts and a nearby children’s hospital. Interviews were conducted with 37 staff, including GPs, hospital doctors, other health care professionals, managers, executives and commissioners. Participants were recruited through purposive and ‘snowball’ sampling methods. Data were analysed following a thematic framework approach. Results. GPs focused on situational difficulties for families, while hospital-based staff emphasized the influence of parents’ beliefs on attendance. Managers, executives and commissioners presented a broad overview of both factors, but with less detailed views. All groups discussed sociodemographic factors, with non-attendance thought to be more likely in ‘chaotic families’. Hospital interviewees emphasized child protection issues and the need for thorough follow-up of missed appointments. However, GPs were reluctant to interfere with parental responsibilities. Conclusion. Parental motivation and practical and social barriers should be considered. Responsibilities regarding missed appointments are not clear across health care sectors, but GPs are uniquely placed to address non-attendance issues and are central to child safeguarding. Primary care policies and strategies could be introduced to reduce non-attendance and ensure children receive the care they require.
Can the Media Affect Us? Social Comparison, Self-Discrepancy, and the Thin Ideal

The current study explored body image self-discrepancy as moderator and social comparison as mediator in the effects on women from thin-ideal images in the media. Female undergraduates (N = 112) with high and low body image self-discrepancy were exposed to advertisements either with thin women (thin ideal) or without thin women (neutral-advertisement control). Exposure to thin-ideal advertisements increased body dissatisfaction, negative mood, and levels of depression and lowered self-esteem. In addition, social comparison processes mediated the relationship between exposure to thin-ideal advertisements and negative self-directed effects. Notably, self-discrepancy moderated this mediation. Women with high levels of body image self-discrepancy were more likely to engage in social comparison from exposure to thin-ideal advertisements, as well as more likely to have those comparison processes induce self-directed negative consequences. This research provides support for an individual difference variable (body image self-discrepancy) that moderates the mediating effect of social comparison from exposure to thin-ideal media.
Identifying Diabetic Patients with High Risk of Readmission

Hospital readmissions are expensive and reflect the inadequacies in healthcare system. In the United States alone, treatment of readmitted diabetic patients exceeds 250 million dollars per year. Early identification of patients facing a high risk of readmission can enable healthcare providers to to conduct additional investigations and possibly prevent future readmissions. This not only improves the quality of care but also reduces the medical expenses on readmission. Machine learning methods have been leveraged on public health data to build a system for identifying diabetic patients facing a high risk of future readmission. Number of inpatient visits, discharge disposition and admission type were identified as strong predictors of readmission. Further, it was found that the number of laboratory tests and discharge disposition together predict whether the patient will be readmitted shortly after being discharged from the hospital (i.e. 30 days). These insights can help healthcare providers to improve inpatient diabetic care. Finally, the cost analysis suggests that \$252.76 million can be saved across 98,053 diabetic patient encounters by incorporating the proposed cost sensitive analysis model.
Women Disrupting a Marginalized Identity: Subverting the Parolee Identity through Narrative

This article uses in-depth interviews to examine the identity work of forty-three women newly released from prison who live in their communities under the supervision of parole. Drawing on hegemonic cultural characters and storylines, the women utilize three narrative strategies that provide them with an opportunity to confront their stigmatized identity and recast their past, present, and future selves on their own terms. By resisting the stigma associated with a felon identity, disassociating from their past drug- and alcohol-using selves, and identifying as good mothers, the women refashion and reaffirm their identities by aligning with conventionality.
Allopurinol as prophylaxis against pouchitis following ileal pouch-anal anastomosis for ulcerative colitis. A randomized placebo-controlled double-blind study.

BACKGROUND Pouchitis is the major long-term complication of restorative proctocolectomy for ulcerative colitis (UC). Allopurinol is a scavenger of oxygen-derived free radicals, which it is suggested play a role in the development of UC and pouchitis. The first aim was to test the hypothesis that the incidence of pouchitis can be reduced by prophylactic Allopurinol, and secondly to evaluate if Allopurinol influences the overall pouch function. METHODS 273 patients with UC who were planned for proctocolectomy and ileal pouch-anal anastomosis at 12 centres in Sweden between October 1994 and June 1997 were offered the opportunity to participate. 184 patients (67%) were randomized to receive postoperative prophylactic Allopurinol 100 mg twice daily or placebo. All 273 patients had clinical and endoscopic follow-up at 1, 3, 6, 12, 18, 24 months after surgery. RESULTS Of the 184 randomized patients, 94 were randomized to Allopurinol and 90 to placebo; 116 patients (63%) completed follow-up and the crude incidence of pouchitis among those patients fullfilling the protocol was 31% in the Allopurinol group and 28% in the placebo group (ns). The cumulative risk for a first attack of pouchitis was 30% and 26% after 24 months (ns). The overall pouch function improved over time and did not differ significantly between the two groups. CONCLUSIONS Prophylactic Allopurinol did not reduce the risk of a first attack of pouchitis.
Exploring a rationale for choosing to listen to sad music when feeling sad

Choosing to listen to self-identified sad music after experiencing negative psychological circumstances seems paradoxical given the commonly-held view that people are motivated to seek a positive affective state when distressed. We examined the motivations people described to listen to music they identified as sad, particularly when experiencing negative circumstances, and the self-reported effects of this activity. We asked adults to respond to an online survey and analyzed their narrative reports using a modified grounded theory approach. Responses were received from 65 adults across five countries. The process that underlies choosing to listen to sad music as well as the self-regulatory strategies and functions of sad music were identified. The music-selection strategies included: connection; selecting music based on memory triggers; high aesthetic value; and message communicated. The functions of these strategies were in the domains of (re-)experiencing affect, cognitive, social, retrieving memories, friend, distraction, and mood enhancement. We additionally modelled the underlying psychological process that guides sad music listening behaviour and the effects of listening. These findings present core insights into the dynamics and value of choosing to listen to self-identified sad music when coping with negative psychological circumstances.
Validating a Written Instrument for Assessing Students' Fractions Schemes and Operations

Previous research has documented schemes and operations that undergird students’ understanding of fractions. This prior research was based, in large part, on small-group teaching experiments. However, written assessments are needed in order for teachers and researchers to assess students’ ways of operating on a whole-class scale. In this study, scores from written instruments used to assess students’ fractions schemes and operations were examined for validity and reliability. Scores from the written assessments were correlated with scores from clinical interviews of 33 sixth graders. Results suggest that the written instruments provide reliable and valid measures for assessing the partitive unit fraction scheme and the splitting operation. However, there is no such evidence regarding the partitive fraction scheme. Implications for teachers and researchers are considered, and possible explanations for the scores from the written assessments related to the partitive fraction scheme are discussed.