Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Zinc Supplementationon the Symptoms of Gastroesophageal Reflux Disease; a Randomized Clinical Trial

BACKGROUND Currently, it has been demonstrated that gastroesophageal reflux disease (GERD) is one of the most important disorders of the digestive system and the commixture of regular diet has a significant influence on its incidence, symptoms, and prognosis. The purpose of this study was to evaluate the effect of zinc supplementation, in combination with PPIs(Proton pump inhibitors), on the improvement of GERD symptoms. METHODS In a randomized double blind clinical trial, patients with reflux symptoms, who had obtained Reflux Disease Questionnaire (RDQ) score more than 8, were included and all the demographic features were recorded. Then, using upper gastrointestinal (GI) endoscopy, all the patients were divided into two groups as having non-erosive reflux disorder (NERD),or erosive reflux disorder (ERD). At the next step, based on random block statistical method, we divided the two groups into two subgroups; the drug subgroup [treated with PPIs (40 mg pantoprazole/daily), changing life style, and 220 mgzinc capsules daily] and the placebo subgroup [treated with PPIs, changing life style, and placebo]. After 3 months, we analyzed all data and the RDQ questionnaire was filled out for each patient. This project has been registered in Iranian Registry of Clinical Trials (IRCT) and all data were analyzed using SPSS software version 2. RESULTS A total of 140 patients (81 women and 59 men) with mean age of 42.78±11.5 years were included with 70 patients in each group. The most frequent presentations were heart burn (45.7%), and acid regurgitation (39.3%). The RDQ scores decreased after intervention in both drug (p<0.001) and placebo groups (p<0.001), which were statistically significant. But the difference of RDQ scores between the drug group and placebo group was not statistically significant (p=0.086). CONCLUSION Zinc supplementation cannot improve the severity of GERD.
Longitudinal Associations between Physical Activity and Educational Outcomes

Purpose This longitudinal study examined the role of leisure-time physical activity in academic achievement at the end of compulsory basic education and educational attainment in adulthood. Methods The data were drawn from the ongoing longitudinal Cardiovascular Risk in Young Finns Study, which was combined with register-based data from Statistics Finland. The study consisted of children who were 12 yr (n = 1723, 49% boys) and 15 yr (n = 2445, 48% boys) of age at the time when physical activity was measured. The children were followed up until 2010, when their mean age was 40 yr. Physical activity was self-reported and included several measurements: overall leisure-time physical activity outside school hours, participation in sports club training sessions, and participation in sports competitions. Individuals’ educational outcomes were measured with the self-reported grade point average at age 15 yr and register-based information on the years of completed postcompulsory education in adulthood. Ordinary least squares models and the instrumental variable approach were used to analyze the relationship between physical activity and educational outcomes. Results Physical activity in adolescence was positively associated with educational outcomes. Both the physical activity level at age 15 yr and an increase in the physical activity level between the ages of 12 and 15 yr were positively related to the grade point average at age 15 yr and the years of postcompulsory education in adulthood. The results were robust to the inclusion of several individual and family background factors, including health endowments, family income, and parents’ education. Conclusion The results provide evidence that physical activity in adolescence may not only predict academic success during compulsory basic education but also boost educational outcomes later in life.
A Practical Approach for Design of Marine Propellers with Systematic Propeller Series

Original scientific paper Although there have been important developments in marine propellers since their first use in 1850, the main concept has been conserved. Parallel to the developments in the computer technologies in the past 50 years, methods based on the circulation theory are often used for the design and analysis of propellers. Due to the ability to predict the propulsion performance with just a few design parameters, the use of systematic propeller series based on open water model experiments is still widespread. The design with standard propeller series is usually made with diagrams developed from model experiments. Reading errors during the use of these diagrams are inevitable. In the presented study a practical approach is developed for preventing reading errors and time loss during the design with standard propeller series. A practical approach based on empirical formulas for the design and performance prediction for four-bladed Wageningen B propeller series is presented, and design applications for three propellers with different loading conditions are realized. The results obtained from the presented method are compared with those of open water diagram data and a good agreement between the results is observed.
Anticancer Activity of Cobra Venom Polypeptide, Cytotoxin-II, against Human Breast Adenocarcinoma Cell Line (MCF-7) via the Induction of Apoptosis

Purpose Breast cancer is a significant health problem worldwide, accounting for a quarter of all cancer diagnoses in women. Current strategies for breast cancer treatment are not fully effective, and there is substantial interest in the identification of novel anticancer agents especially from natural products including toxins. Cytotoxins are polypeptides found in the venom of cobras and have various physiological effects. In the present study, the anticancer potential of cytotoxin-II against the human breast adenocarcinoma cell line (MCF-7) was investigated. Methods The cytotoxic effects of cytotoxin-II were determined by morphological analysis and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The mode and mechanism of cell death were investigated via acridine orange/ethidium bromide (AO/EtBr) double staining, flow cytometric analysis of cell death, detection of mitochondrial membrane potential, measurement of intracellular reactive oxygen species (ROS), annexin V/propidium iodide staining, and caspase-9 activity assays. Results The half maximal inhibitory concentration (IC50) of cytotoxin-II in MCF-7 cells was 4.18±1.23 µg/mL, while the value for cisplatin was approximately 28.02±1.87 µg/mL. Morphological analysis and AO/EtBr double staining showed typical manifestations of apoptotic cell death (in doses lower than 8 µg/mL). Dose- and time-dependent ROS generation, loss of mitochondrial membrane potential, caspase-9 activation, and cell cycle arrest were observed in their respective tests. Conclusion In conclusion, cytotoxin-II has potent anticancer effects in the MCF-7 cell line, which are induced via the intrinsic pathways of apoptosis. Based on these findings, cytotoxin-II is a suitable choice for breast cancer treatment.
Ur Scholarship Repository Differential Cross Section and Recoil Polarization Measurements for the Γp→k + Λ Reaction Using Clas at Jefferson Lab Reaction Using Clas at Jefferson Lab

We present measurements of the differential cross section and recoil polarization for the γp → K + reaction made using the CLAS detector at Jefferson Lab. These measurements cover the center-of-mass energy range from 1.62 to 2.84 GeV and a wide range of center-of-mass K + production angles. Independent analyses were performed using the K + pπ − and K + p (missing π −) final-state topologies; results from these analyses were found to exhibit good agreement. These differential-cross-section measurements show excellent agreement with previous CLAS and LEPS results and offer increased precision and a 300-MeV increase in energy coverage. The recoil polarization data agree well with previous results and offer a large increase in precision and a 500-MeV extension in energy range. The increased center-of-mass energy range that these data represent will allow for independent study of nonresonant K + photoproduction mechanisms at all production angles.
Actions of barium and rubidium on membrane currents in canine Purkinje fibres.

The actions of Ba2+ and Rb+, two blockers of background K+ conductance, were investigated. Recent studies performed on ungulate Purkinje fibres have suggested that the pace‐maker current is an inward current activated by hyperpolarization. This hypothesis is based on the assumption that Ba2+ reduces the inwardly rectifying background K+ conductance without affecting the pace‐maker current. Addition of 5 mM‐BaCl2 to the bathing Tyrode solution decreases background K+ permeability and eliminates the reversal of the pace‐maker current. The reversal reappears on return to Ba2+‐free Tyrode solution. 5 mM‐BaCl2 also reduces the time‐dependent current at pace‐maker potentials positive to about ‐95 mV in 4 mM‐K+ Tyrode solution. The pace‐maker current in Ba2+ Tyrode solution usually does not have an exponential time course, and often decays non‐monotonically. It can take more than two minutes to reach a steady state. The fast initial component of membrane current, which is observed on hyperpolarizing in the pace‐maker potential range in Purkinje fibres and which has been called the ‘depletion current', is still present in Ba2+ Tyrode solution, but is reduced or eliminated if 10 mM‐CsCl is added to the Ba2+ Tyrode solution. The addition of Cs+ is accompanied by an outward shift in membrane current in Ba2+ Tyrode solution. Ba2+ reduces the background K+ permeability in a dose‐dependent manner. Addition of between 0.5 and 1 mM‐BaCl2 achieves a maximum effect. Raising the amount of BaCl2 above this level reduces the time‐dependent current even when no further effect on background permeability is observed. Rb+ substitution for K+ reduces the magnitude of the pace‐maker current at potentials positive to ‐100 mV, eliminates the reversal of the pace‐maker current, shifts the activation range to more negative potentials, and decreases the voltage dependence of pace‐maker current kinetics. Rb+ addition to Tyrode solution has little effect on pace‐maker current magnitude or time course positive to ‐90 mV, but does shift the reversal to more negative potentials. The available evidence suggests that the pace‐maker current in Ba2+ Tyrode solution is an inward current activated by hyperpolarization. However, Ba2+ blocks an unknown fraction of the pace‐maker current in a dose‐dependent, and possibly voltage‐dependent manner. Also, the presence of a slow component of pace‐maker decay suggests that the standard Hodgkin‐Huxley formalism for the analysis of pace‐maker currents is inappropriate.
Adaptation to Different Rates of Environmental Change in Chlamydomonas

We investigate how different rates of environmental change affect adaptive outcomes and dynamics by selecting Chlamydomonas populations for over 200 generations in environments where the rate of change varies. We find that slower rates of environmental change result in end populations that grow faster and pay a lower cost of adaptation than populations that adapt to a sudden change of the same magnitude. We detected partial selective sweeps in adapting populations by monitoring changes in marker frequency in each population. Although populations adapting to a sudden environmental change showed evidence of mutations of large effect segregating early on, populations adapting to slow rates of change showed patterns that were consistent with mutations of relatively small effect occurring at less predictable times. This work suggests that rates of environmental change may fundamentally alter adaptive dynamics and outcomes of adaptation by changing the size and timing of fitness increases. We suggest that using mutations of smaller effect during adaptation may result in lower levels of pleiotropy and historical constraints, which could in turn result in higher fitness by the end of the experiment.
The Academy of Management annals

1. The Fundamental Agency Problem and Its Mitigation: Independence, Equity, and the Market for Corporate Control (Dan R. Dalton, Michael A. Hitt, S. Trevis Certo and Catherine M. Dalton) 2. Old Assumptions, New Work: The Opportunities and Challenges of Research on Nonstandard Employment (Susan J. Ashford, Elizabeth George and Ruth Blatt) 3. Critical Management Studies (Paul S. Adler, Linda C. Forbes and Hugh Willmott) 4. The Physical Environment in Corporate Work Settings (Kimberly D. Elsbach and Michael G. Pratt) 5. Public Administration and Organization Studies (Steven Kelman) 6. Three Perspectives on Team Learning: Outcome Improvement, Task Mastery, and Group Process (Amy C. Edmondson, James R. Dillon and Kathryn S. Roloff) 7. Emotion in Organizations: A Review in Stages (Hillary Anger Elfenbein) 8. Leadership Research in Healthcare: A Review and Roadmap (Mattia J. Gilmartin and Thomas A. D'Aunno) 9. Creativity in Organizations (Jennifer M. George) 10. Learning and Strategic Alliances (Andrew C. Inkpen and Eric W. K. Tsang) 11. Postcards from the Edge: A Review of the Business and Environment Literature (Luca Berchicci and Andrew King) 12. HRM and Distributed Work: Managing People Across Distance (John Paul MacDuffie) 13. Bias in Performance Appraisal: A Review of Theory and Findings (Loriann Roberson, Benjamin M. Galvin, Atria Cherise Charles)
DESENTRALISASI DAN GAYA KEPEMIMPINAN SEBAGAI VARIABEL MODERATING DALAM HUBUNGAN ANTARA PARTISIPASI PENYUSUNAN ANGGARAN DAN KINERJA MANAJERIAL (Studi Kasus Pada Rumah Sakit di Wilayah Surakarta)

Partisipasi penyusunan anggaran merupakan pendekatan yang secara umum dapat meningkatkan kinerja yang pada akhirnya dapat meningkatkan efektivitas organisasi. Selain sebagai alat untuk mencapai tujuan, partisipasi juga sebagai alat untuk mengintegrasi kebutuhan individu dan organisasi. Sehingga partisipasi dapat diartikan sebagai pengaruh, pendelegasian prosedur-prosedur, keterlibatan dalam pengambilan keputusan dan suatu pemberdayaan. Penelitian ini bertujuan untuk mengetahui pengaruh partisipasi penyusunan anggaran terhadap kinerja manajerial yang dimoderasi oleh desentralisasi dan gaya kepemimpinan. Populasi dalam penelitian ini adalah kepala bagian yang bekerja pada rumah sakit di wilayah Surakarta. Penelitian ini menggunakan teknik sampling dalam pengumpulan data yang diperlukan. Teknik sampling yang digunakan adalah purposive sampling, karena penulis menggunakan kriteria tertentu dalam memilih sampel, berdasarkan kriteria yang telah ditetapkan diperoleh jumlah sampel sebanyak 55 responden. Teknik pengumpulan data menggunakan kuesioner dan analisis data menggunakan analisis regresi linier berganda, uji t dan uji F. Berdasarkan analisis data yang digunakan yaitu regresi linier berganda, uji t dan uji F, maka dapat disimpulkan bahwa variabel partisipasi penyusunan anggaran mempunyai pengaruh yang signifikan terhadap kinerja manajerial. Variabel desentralisasi tidak memoderasi pengaruh partisipsai penyusunan anggaran terhadap kinerja manajerial. Variabel gaya kepemimpinan memoderasi pengaruh partisipasi penyusunan anggaran terhadap kinerja manajerial.
TWO SIDES OF THE SAME COIN? ASSESSING THE DISTINCTNESS OF STIGMA CONCEALMENT AND DISCLOSURE PROCESSES

Title of Document: TWO SIDES OF THE SAME COIN? ASSESSING THE DISTINCTNESS OF STIGMA CONCEALMENT AND DISCLOSURE PROCESSES Skyler D. Jackson, Master of Science, 2014 Thesis directed By: Assistant Professor, Jonathan J. Mohr Department of Psychology Past scholarship is divided regarding whether stigma concealment and disclosure represent a unidimensional construct. This study used an online survey to investigate the distinctness of these stigma management processes among 298 sexual minority undergraduate and graduate students. The association demonstrated between stigma concealment and disclosure in this investigation suggests that they are related but ultimately distinct aspects of identity management. This finding was reinforced by numerous cases in which these stigma management variables uniquely predicted factors of psychological health (depression and life satisfaction) or aspects of identity adjustment (self-stigma, acceptance concerns, membership esteem, and identity strength). Additionally, as compared to stigma disclosure, stigma concealment was found to be a better predictor of both factors of psychological health and one aspect of identity adjustment (acceptance concerns). The implications of these results are discussed in light of literature on individuals with indiscernible stigmatized identities and may inform clinical practice and future research. TWO SIDES OF THE SAME COIN? ASSESSING THE DISTINCTNESS OF STIGMA CONCEALMENT AND DISCLOSURE PROCESSES By Skyler D. Jackson Thesis submitted to the Faculty of the Graduate School of the University of Maryland, College Park, in partial fulfillment of the requirements for the degree of Master of Arts 2014 Advisory Committee: Assistant Professor Jonathan J. Mohr, Chair Professor Charles J. Gelso Associate Professor Matthew J. Miller © Copyright by Skyler D. Jackson 2014
Excessive Deflections of Record-Span Prestressed Box Girder

The Koror-Babeldaob (KB) Bridge, built in 1977, connected the islands of Koror and Babeldaob in the Republic of Palau. It had a main span of 241 m, which once set the world record for a segmentally built prestressed concrete box girder. After 18 years, deflection became so excessive that it was decided to install additional prestressing and eliminate the bridge's midspan hinge. However, 3 months after retrofitting was completed and the KB Bridge was re-opened, it suddenly collapsed under negligible traffic load and with no apparent external trigger in September 1996. In design, the final midspan deflection accumulated since the end of cantilever erection, measured from the design camber of -0.30, was expected to be in the tolerable range from 0.76 to 0.88 m, which would have led to a final sag of only 0.46 to 0.58 m compared to the design elevation. During the first 2 years, the deflections were benign but then accelerated unexpectedly. After 18 years, the deflection increase, measured since the installation of the midspan hinge, reached 1.39 m and kept growing . Compared to the design camber, additional creep deflection of 0.22 m was accumulated earlier during segmental erection, and so the total deflection was 1.61 m. This study has a two-fold objective: 1) explain the excessive deflections, and 2) compare the predictions obtained with the main existing creep and shrinkage prediction models currently used in practice. Investigation of the collapse itself will be presented in a later article. Due to length limitations, details of the creep and shrinkage analyses cannot be presented here, but can be found in a recent report available at www.civil. northwestern.edu/people/bazant/PDFs/Papers.
Eradication of gastric Helicobacter spp. by triple therapy in dogs.

The aim of this study was to determine the efficacy of a triple anti- Helicobacter therapy using ome - prazole, amoxicillin and clarithromycin (OAC) in dogs. A total of 15 healthy adult stray dogs with naturally acquired Helicobacter infection were evaluated using polymerase chain reaction and rapid urease test. Subsequently, they received a 21-day triple regimen. One day after the discontinuation of treatment, a second molecular analysis of gastric biopsies revealed complete eradication of Helicobacter DNA with negative quantitative urease testing in all 15 dogs. Our results confirmed the high prevalence of gastric Helicobacter-like organisms (GHLOs) in the stray dog population of Shiraz, Iran, and the effectiveness of our therapeutic regimen for the complete eradication of these microorganisms in stray dogs. In conclusion, for the complete elimination of non- pylori Helicobacter spp. from the gastric mucosa of dogs, a 21-day three-drug regimen with omeprazole, amoxicillin and clarithromycin is suggested.
Nasopharyngeal Carriage of Penicillin-ResistantStreptococcus pneumoniae among Children with Acute Respiratory Tract Infections in Thailand: a Molecular Epidemiological Survey

ABSTRACT The prevalence of penicillin-resistant Streptococcus pneumoniae in Thailand has dramatically increased over the last decade. During a national survey, which was conducted from 1992 to 1994, 37.2% of the pneumococci isolated from the nasopharynges of children with acute respiratory tract infections were penicillin resistant (MIC, ≥0.1 μg/ml). In order to investigate the prevalence and clonal relatedness of nasopharyngeal carriage of penicillin-resistant S. pneumoniae in Thailand, a molecular epidemiological survey was undertaken. To this end, 53 penicillin-resistant pneumococcal isolates from children who suffered from acute respiratory tract infections and who originated from five distinct regions of the country were characterized in detail. DNA fingerprint analysis demonstrated 13 clusters, i.e., genotypes shared by two or more strains, and 14 unique genotypes. The cluster size varied from 2 (nine clusters) to 11 strains (one cluster). Six of the 13 restriction fragment end labeling clusters consisted of two or more distinct serotypes, indicating frequent horizontal transfer of capsular genes. Geographical distribution of the genotypes among the five regions of Thailand demonstrated that only four genetic clusters were restricted to single areas of the country, whereas the other nine clusters represented isolates collected in two or more districts. These observations demonstrate that the majority of the genetic clusters are spread throughout the country. The most predominant genetic cluster, representing 21% of the isolates, was identical to the Spanish pandemic clone 23F. In addition, the second largest cluster matched the Spanish-French international clone 9V. These data indicate that the genetic clones 23F and 9V, which are widely spread throughout the world, are the most predominant multidrug-resistant pneumococcal clones in Thailand. Therefore, we conclude that these pandemic clones are primarily responsible for the increase in the prevalence of pneumococcal penicillin resistance in Thailand.
Recent advances in understanding the bias temperature instability

Our understanding of the bias temperature instability (BTI) has been plagued by disagreements related to measurement issues. Although even in the early papers on BTI the existence of recovery was acknowledged and discussed [1, 2], for unknown reasons this had little impact on the way we used to think about the phenomenon until recently [3–7]. Even after the re-discovery of recovery [3], it took a few years until it was fully appreciated that any measurement scheme conceived so far considerably interferes with the degradation it is supposed to measure, often accelerating its recovery. Nonetheless, this experimental nuisance has led researchers to think in more detail about the problem and has thus opened the floodgates for fresh ideas [6–11]. Some of these ideas together with the experimental data supporting them are reviewed in the following.
Essays on Analytical Music Therapy

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