Miracle-dz/UniFAR-FTUs huggingface dataset:
One Session Group Treatment of Spider Phobia by Direct or Modelled Exposure

Exposure therapy is the most effective treatment for specific phobias. The one-session procedure is a further development of the effectiveness of exposure therapy. The aims of this study were to determine whether a modelled version of exposure is also effective and what kind of efficiency gradient different procedures produce. A total of 38 patients with spider phobia participated in the study. They were assigned randomly to 3 different procedures: (i) direct exposure; (ii) model exposure; or (iii) video exposure. Diagnosis was established with DSM-III-R and the Fear Survey Schedule. Self-report questionnaires assessed cognitions, body sensation symptoms, self-efficacy and long-term effect evaluation. The results gave a significant time effect for cognitions, body sensations and self-efficacy. There was also a significant time effect and interaction for the evaluation of treatment and a time by group interaction for self-efficacy. Direct exposure seemed to produce the best long-term results.
Biased Agonism as a Novel Strategy To Harness the Proresolving Properties of Melanocortin Receptors without Eliciting Melanogenic Effects

There is a need for novel approaches to control pathologies with overexuberant inflammatory reactions. Targeting melanocortin (MC) receptors represents a promising therapy for obesity and chronic inflammation, but lack of selectivity and safety concerns limit development. A new way to increase selectivity of biological effects entails the identification of biased agonists. In this study, we characterize the small molecule AP1189 as a biased agonist at receptors MC1 and MC3. Although not provoking canonical cAMP generation, AP1189 addition to MC1 or MC3, but not empty vector, transfected HEK293 cells caused ERK1/2 phosphorylation, a signaling responsible for the proefferocytic effect evoked in mouse primary macrophages. Added to macrophage cultures, AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r−/− and Mc3r−/− macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ∼3-fold. Finally, given the clinical efficacy of adrenocorticotropin in joint diseases, AP1189 was tested in experimental inflammatory arthritis, where this biased agonist afforded significant reduction of macroscopic and histological parameters of joint disruption. These proof-of-concept analyses with AP1189, an active oral anti-inflammatory and resolution-promoting compound, indicate that biased agonism at MC receptors is an innovative, viable approach to yield novel anti-inflammatory molecules endowed with a more favorable safety profile.
An important role for endogenous synthesis of arginine in maintaining arginine homeostasis in neonatal pigs.

This study was designed to test the hypothesis that endogenous arginine synthesis plays an important role in maintaining arginine homeostasis in neonatal pigs. Gabaculine was used as a suicide inhibitor of ornithine aminotransferase to decrease the intestinal conversion of glutamine-derived pyrroline-5-carboxylate (P-5-C) into ornithine, the precursor of both citrulline and arginine. Four-day-old suckling pigs received oral administration of 0.0 or 0.83 mg gabaculine/kg body wt every 4 h during a 12-h period from 6 A.M. to 6 P.M. Blood was collected from piglet's jugular vein at 6 A.M. and 6 P.M. after a 2-h isolation from sows. Gabaculine treatment decreased plasma concentrations of ornithine, citrulline, and arginine by 59, 52, and 76%, respectively, and increased those of glutamine and proline by 74 and 220%, respectively. The gabaculine treatment also increased plasma concentrations of leucine, taurine, and ammonia by 29, 42, and 20%, respectively. There were no differences in intramuscular concentrations of amino acids between control and gabaculine-treated pigs. Because P-5-C synthase (the enzyme required for synthesis of P-5-C from glutamate) was almost exclusively located in enterocytes of 4-day-old pigs, our data suggest that the intestinal production of citrulline plays an important role in endogenous synthesis of arginine and its homeostasis in neonatal pigs.
Serum uric acid in acute myocardial infarction.

BACKGROUND There is evidence that high uric acid is a negative prognostic factor in patients with mild to severe heart failure. A study showed a close correlation between serum uric acid concentration and Killip classification in patients of acute myocardial infarction. MATERIAL AND METHODS We studied 100 patients with acute myocardial infarction and 50 controls. Serum uric acid level was measured on day 0, 3 & 7 of MI. RESULTS There was a statistically significant higher level of serum uric acid concentration in patients of MI on day of admission as compared to controls. Patients with history of MI in the past had higher serum uric acid levels. On all the days serum uric acid levels were higher in patients who were in higher Killip class. All the five patients who died after 3 days of hospital stay had serum uric acid level more than 7.0 gm/dL and all of them were Killip class IV. CONCLUSIONS Serum uric acid levels are higher in patients of acute myocardial infarction correlated with Killip class. Combination of Killip class and serum uric acid level after acute myocardial infarction is a good predictor of mortality after AMI.
THE RESPONSE IN A LINEAR PROGRAM: ITS MODE AND IMPORTANCE

Abstract A 48‐frame linear program on number bases was presented to forty‐seven boys in the first year at a secondary school. The boys were arranged in two ability groups, high and low, based on their school mathematics examinations. In each group there was a random assignment to one of three treatment groups. The first wrote down their responses in the conventional way; the second thought their responses but wrote nothing down; the third read through a program in which the blanks had been filled in. Two parallel tests were given, one immediately on completion of the program, and the other after an interval of twenty‐seven days. ‐ No significant differences in the mean scores between treatments at either ability level were found on the immediate test, nor on the delayed test. Retention was assessed on the basis of the gain scores, and here it was found that there was a significant interaction. Among those of high ability the written response group were significantly better than the text format group at the.
Human and Pneumococcal Cell Surface Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Proteins Are Both Ligands of Human C1q Protein*

Background: C1q is a major molecule of the immune innate system. GAPDH exposed at the surface of cells is associated with the virulence of pathogens. Results: C1q binds GAPDH on human apoptotic and on pneumococcal cells. Conclusion: GAPDH is a C1q ligand. Pneumococcal GAPDH-C1q interaction leads to complement activation. Significance: This might bring new insights into host defense against pathogens. C1q, a key component of the classical complement pathway, is a major player in the response to microbial infection and has been shown to detect noxious altered-self substances such as apoptotic cells. In this work, using complementary experimental approaches, we identified the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a C1q partner when exposed at the surface of human pathogenic bacteria Streptococcus pneumoniae and human apoptotic cells. The membrane-associated GAPDH on HeLa cells bound the globular regions of C1q as demonstrated by pulldown and cell surface co-localization experiments. Pneumococcal strains deficient in surface-exposed GAPDH harbored a decreased level of C1q recognition when compared with the wild-type strains. Both recombinant human and pneumococcal GAPDHs interacted avidly with C1q as measured by surface plasmon resonance experiments (KD = 0.34–2.17 nm). In addition, GAPDH-C1q complexes were observed by transmission electron microscopy after cross-linking. The purified pneumococcal GAPDH protein activated C1 in an in vitro assay unlike the human form. Deposition of C1q, C3b, and C4b from human serum at the surface of pneumococcal cells was dependent on the presence of surface-exposed GAPDH. This ability of C1q to sense both human and bacterial GAPDHs sheds new insights on the role of this important defense collagen molecule in modulating the immune response.
Synthesis, structure, and magnetism of Np(2)O(5).

The binary oxide Np2O5 has been synthesized by mild hydrothermal reaction and its crystal structure has been determined. It is monoclinic, P2/c, Z = 4, a = 8.168(2), b = 6.584(1), c = 9.313(1) A, β = 116.09(1)°, V = 449.8(2) A3. The structure contains neptunyl square and pentagonal bipyramids that are linked into sheets by edge-sharing. Cation−cation interactions occur within the sheet of polyhedra and provide linkages of the sheets into a three-dimensional structure. Np2O5 undergoes antiferromagnetic ordering at 22(3) K, the highest magnetic ordering temperature observed for any neptunyl compound, and is only the second neptunyl compound found to order antiferromagnetically.
The Nature of Pride

As the epigraph illustrates, feeling pride in oneself, or having one’s “passions” “cluster about the ego,” is a central part of human nature. Scheff (1988, p. 399) went so far as to claim, “We are virtually always in a state of pride or shame. ” Although this statement may be somewhat extreme, Scheff made a prescient observation: our everyday lives are frequently infused with a sense of mastery and achievement, or conversely, frustration and failure, and we react to these self-relevant events with often intense self-conscious emotions. Yet, despite the importance of pride to everyday social life, this emotion has received relatively little research attention, particularly compared with fear, joy, and other socalled basic emotions. Like all self-conscious emotions, pride is generally viewed as a “secondary” emotion (Lewis, Sullivan, Stanger, & Weiss, 1989), and even compared with other self-conscious emotions pride is something of an underdog. A PsycINFO search found only 208 publications with the words “pride” or “proud” in their title, compared with 1,633 publications with the words “guilt” or “guilty,” and 1,312 with the words “shame” or “ashamed. ” Similarly, in Tangney and Fischer’s (1995) volume on self-conscious emotions, not a single chapter provided a review of the extant research or theory on pride, and only four of the 20 chapters discussed it. However, a growing body of research may change all this: new theory and findings support the views of Cooley and Scheff, and suggest that pride is a psychologically important and evolutionarily adaptive emotion. The pleasurable subjective feelings that accompany a pride experience may reinforce the prosocial behaviors that typically elicit the emotion, such as achievement and caregiving (Hart & Matsuba, Chapter 7, this volume;
Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity

The in situ formation of silver nanoparticles (AgNPs) aided by chondroitin sulfate and the preparation of a hierarchically structured silver-polymer nanocomposite with antimicrobial activity is shown. Green synthesis of AgNPs is carried out by thermal treatment (80 and 90 °C) or UV irradiation of a chondroitin sulfate solution containing AgNO3 without using any further reducing agents or stabilizers. Best control of the AgNPs size and polydispersity was achieved by UV irradiation. The ice-segregation-induced self-assembly (ISISA) process, in which the polymer solution containing the AgNPs is frozen unidirectionally, and successively freeze-drying were employed to produce the chondroitin sulfate 3D scaffolds. The scaffolds were further crosslinked with hexamethylene diisocyanate vapors to avoid water solubility of the 3D structures in aqueous environments. The antimicrobial activity of the scaffolds was tested against Escherichia coli. The minimum inhibitory concentration (MIC) found for AgNPs-CS (chondroitin sulfate) scaffolds was ca. 6 ppm.
Reconfiguring self/identity/status/role: the case of professional role performance in healthcare encounters

Concepts such as self, identity, status and role are central to discourse analytical endeavours. However, these concepts are used interchangeably, and sometimes in a conflated manner (e.g., self-identity, role-identity), by scholars within and across different analytical domains with overlapping ontological and epistemological trajectories. Beginning with a broader theoretical discussion of self, status and identity from sociological and social psychological traditions, in this paper I focus on role and role performance in professional settings. Using Goffman’s work as a bridge I then offer an interactional perspective on role performance which is extended to the doctorpatient relationship in healthcare encounters. The illustrative data examples are taken from the primary care setting, drawing attention to the doctor’s competing roles, i.e., therapeutic and pedagogic, contained within the professional role-set in an ethos which is predominantly steered towards patient-centred healthcare delivery. My main argument is that an examination of professional role-performance at the interactional level is capable of offering interesting theoretical and empirical insights.
The most common nursing diagnosis among adults/seniors hospitalised with cancer: integrative review

The nursing process, with emphasis on the diagnosis phase, is essential to oncology hospital services due to a high frequency of physical and psychological problems that compromise the quality of life of patients undergoing cancer treatment. The goal of this study was to identify, according to NANDA International, the most common nursing diagnosis among adults/seniors with cancer who are hospitalised. This study is an integrative review of the literature completed in 2013 using five electronic databases, resulting in the selection and analysis of nine articles. This review identified the following eight actual diagnoses and two risk diagnoses that are more common among hospitalised adults/seniors with cancer: anxiety, deficient knowledge, constipation, self-care deficit for bathing/hygiene, body image disturbance, acute/chronic pain, fear, disturbed sleep pattern, risk of infection, and risk of deficient fluid volume. The heterogeneity of the studies used in this review may not have allowed the identification of all the common nursing diagnoses in the practice of oncology nursing in hospitals. However, even though the results are not based on the highest possible level of scientific evidence, their correlation to clinical practice can contribute to the enhancement of the nursing process in oncology services provided by hospitals.
Optimization and Analysis of Probabilistic Caching in $N$ -Tier Heterogeneous Networks

In this paper, we study the probabilistic caching for an <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula>-tier wireless heterogeneous network (HetNet) using stochastic geometry. A general and tractable expression of the successful delivery probability (SDP) is first derived. We then optimize the caching probabilities for maximizing the SDP in the high signal-to-noise ratio regime. The problem is proved to be convex and solved efficiently. We next establish an interesting connection between <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula>-tier HetNets and single-tier networks. Unlike the single-tier network where the optimal performance only depends on the cache size, the optimal performance of <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula>-tier HetNets depends also on the base station (BS) densities. The performance upper bound is, however, determined by an equivalent single-tier network. We further show that with uniform caching probabilities regardless of content popularities, to achieve a target SDP, the BS density of a tier can be reduced by increasing the cache size of the tier when the cache size is larger than a threshold; otherwise, the BS density and BS cache size can be increased simultaneously. It is also found analytically that the BS density of a tier is <italic>inverse</italic> to the BS cache size of the same tier and is <italic>linear</italic> to BS cache sizes of other tiers.
Identifying Good Connections in an Unstructured Peer-to-Peer Network: The Case of Gnutella

Past studies have shown the unstability of unstructured peer-to-peer networks and in particular Gnutella. Because of this unstability, queries in these networks are inefficient. Furthermore, to keep the network stable, the protocols used require huge bandwidth usage. One approach proposed by Gnutella conceptors is to create two classes of servents: leaf nodes and ultrapeers. The core of the network is preserved by the ultrapeers, while the leaf nodes remain at the periphery. Others suggest to use random walks rather than flooding. We also see suggestions to build communities to reduce traffic. In this paper, we investigate the possibility to use a different, yet complementary approach, where a node would only keep connections that it deems “good”. Based on statistics collected on the Gnutella network, we show that it is possible to rapidly determine whether a connection is good or not. The detection of good connections uses two criteria: the duration of connection establishment time and the number of messages received through the connection.
Encounters in the ONC - observing imprints of star-disc interactions

Context. The external destruction of protoplanetary discs in a clustered environment acts mainly due to two mechanisms: gravitational drag by stellar encounters and evaporation by strong stellar winds and radiation. It is a fundamental question whether either of these mechanisms is important for the stellar evolution and planet formation process in young star clusters. Aims. We focus on the effect of stellar encounters in young dense clusters and investigate whether there are any observables that could trace this mechanism and its impact on disc evolution. If encounters play a role in disc destruction, one would expect that stars devoid of disc material would show unexpectedly high velocities as an outcome of close interactions. We want to quantify this effect by numerical simulations and compare it to observations. Methods. As a model cluster we chose the Orion Nebula Cluster (ONC). We reanalyzed observational data of the ONC to find encounter signatures in the velocity distribution and a possible correlation with signatures of circumstellar discs. We use the nbody6++ code to model the dynamics of an ONC-like cluster and analyze the velocity distribution and the disc-mass loss due to encounters. Results. We found from the observational data that 8 to 18 stars leave the ONC with velocities several times the velocity dispersion. The majority of these high-velocity stars are young low-mass stars (t 10 5 yr, m ≈ 0.2–0.3 M� ), among them several lacking infrared excess emission. Interestingly, the high-velocity stars are found only in two separate regions of the ONC – i) close to the cluster centre and ii) in the outer cluster region. Our simulations give an explanation for the location of the high-velocity stars and provide evidence for a strong correlation between location and disc destruction. Conclusions. The high-velocity stars can be explained as the outcome of close three-body encounters; the partial lack of disc signatures is attributed to gravitational interaction. The spatial distribution of the high-velocity stars reflects the initial structure and dynamics of the ONC. Our approach can be generalized to study the evolution of other young dense star clusters, like the Arches cluster, back in time.
Commodifying the countryside: the impact of out‐of‐school care on rural landscapes of children's play

The growing interest in rural geography has highlighted that symbolic representations of the ‘rural idyll’ are often contradictory to the lived experiences of many rural children. Increasingly, children's spatial mobility is restricted due to adult concerns over children's use of public space, and the continuing privatization of rural space. Whilst children are prevented from using the countryside as a resource, there is also a lack of provision and spaces dedicated to children's play. One exception to this is the development of out-of-school care schemes. The rapidly expandingout-of-school care service is providing rural children with a significant, well-resourced place for children to play. This paperexamines children's experiences of playing in the countryside, and discusses the impact of the developing out-of-school care service on the daily lives of children who experience the service. The paper also considers the impact of commodifying children's play on the ability of all children to access a local play service.
Clínica ampliada na atenção básica e processos de subjetivação: relato de uma experiência

A proposta da Estrategia de Saude da Familia (ESF) privilegia acoes de promocao a saude, desenvolvidas pela equipe de profissionais junto com a comunidade. Na imanencia desse coletivo, encontramos linhas disparadoras de processos reflexivos que podem liberar a producao de um saber-fazer criativo. Neste sentido, a insercao da psicologia nos Nucleos de Apoio a Saude da Familia (NASF) pode contribuir para a efetivacao de uma clinica ampliada na rede basica, critica aos modelos ditos saudaveis, na maioria das vezes ortopedicos e modeladores, aberta a experimentacoes e ocupada em religar clinica-politica-producao de modos de vida. Neste artigo problematizamos algumas demandas dirigidas a psicologa integrante do NASF pelas equipes da ESF, sua producao e implicacoes etico-politicas para o exercicio da clinica e processos de subjetivacao resultantes. Trata-se de um estudo de caso que buscou percorrer e mapear nos discursos possiveis interlocucoes e agenciamentos, cujas expressoes sao traduzidas como demanda para os profissionais da saude. Em muitos casos, tais enunciados exprimem consideracoes morais, formas idealizadas de saude e bem-estar. Apostamos que a construcao da clinica e produto de um coletivo desejante, capaz de resistir aos mecanismos de captura e disciplinarizacao da vida. Este trabalho propoe que, a partir das provocacoes do cotidiano, a equipe dialogue, questione e se fortaleca, para afirmar formas de existir saudaveis e livres de padroes preestabelecidos.
A new modulation method for matrix converters

This paper presents a new modulation method for matrix converters based on the indirect modulation model. During the switching period, the proposed modulation method uses a combination of only one active vector and a zero vector in the inversion stage to achieve minimum flux error, while in the rectification stage a single current vector is selected, according to the error of the input current vector angle. This reduces the number of switching sequences in the switching period, improving the accuracy of generating the output voltage vector especially in the low modulation index range. Supplementary, the direct control of the input current vector is implemented. The estimation of the angle of the input current vector is done by applying the inverse transformation, that corresponds to the applied active vector, to the output currents.