Miracle-dz/UniFAR-FTUs huggingface dataset:
Tony Manninen Rich Interaction Model for Game and Virtual Environment Design

The focus of this thesis is on perceivable interaction forms that can be utilised in multi-player computer games and Collaborative Virtual Environments (CVEs). Interaction forms are manifestations of user-user and user-environment interaction. These forms convey the actions of the user to others, and to oneself, during synchronous communication and interaction partially resembling face-to-face encounters in the physical world. The communication, co-ordination and collaboration difficulties in current 3D CVEs have yet to be overcome. The aim of this thesis is to conceptualise and delineate the available mutually perceivable interaction forms. The research analyses entertainment industry solutions and examines their potential as providers of design implications for CVE systems in general. Furthermore, games are used as platforms in the construction phases of the research. The research answers the problems of what interaction forms exist in multi-player games and what are their main characteristics and how to apply the understanding of possible interaction forms in order to help the design of games and professionally used CVEs? The problems are approached with conceptual analytical and constructive methods. Delineation and categorisation of various interaction forms in games and CVEs is presented. The gap between theoretical models and practical design is bridged by using several empirical cases as a constructive part of the research. The significance of this research is related to the increasingly important role of CVEs in global organisations and virtual enterprises, as well as in the everyday life of people. The communicational and functional enhancements of the virtual environments and multi-player games make the interpersonal interaction more usable and applicable in computer mediated settings. The research provides a deeper understanding of the concept of interaction forms in the context of CVEs and multiplayer games. The results can be used to create more supportive, appealing and communicative applications by applying interaction models and theories in the form of rich interaction design guidelines. The main contributions of this research are the conceptual models of interaction forms and corresponding rich interaction design suggestions. The results reveal important and neglected aspects of interaction forms to the world of game and virtual environment designers. Combined with the descriptions of interaction design processes the overall outcome of the work is applicable to a wide audience designing or using computer systems that support communication, co-ordination and collaboration.
Superconvergence and Gradient Recovery of Linear Finite Elements for the Laplace-Beltrami Operator on General Surfaces

Superconvergence results and several gradient recovery methods of finite element methods in flat spaces are generalized to the surface linear finite element method for the Laplace-Beltrami equation on general surfaces with mildly structured triangular meshes. For a large class of practically useful grids, the surface linear finite element solution is proven to be superclose to an interpolant of the exact solution of the Laplace-Beltrami equation, and as a result various postprocessing gradient recovery, including simple and weighted averaging, local and global $L^2$-projections, and Zienkiewicz and Zhu (Z-Z) schemes are devised and proven to be a better approximation of the true gradient than the gradient of the finite element solution. Numerical experiments are presented to confirm the theoretical results.
Fusion of Perception and V2P Communication Systems for the Safety of Vulnerable Road Users

With cooperative intelligent transportation systems, vulnerable road users (VRU) safety can be enhanced by multiple means. On the one hand, perception systems are based on embedded sensors to protect VRUs. However, such systems may fail due to the sensors’ visibility conditions and imprecision. On the other hand, vehicle-to-pedestrian (V2P) communication can contribute to the VRU safety by allowing vehicles and pedestrians to exchange information. This solution is, however, largely affected by the reliability of the exchanged information, which most generally is the GPS data. Since perception and communication have complementary features, we can expect that a fusion between these two approaches can be a solution to the VRU safety. In this paper, we propose a cooperative system that combines the outputs of communication and perception. After introducing theoretical models of both individual approaches, we develop a probabilistic association between perception and V2P communication information by means of multi-hypothesis tracking. Experimental studies are conducted to demonstrate the applicability of this approach in real-world environments. Our results show that the cooperative VRU protection system can benefit of the redundancy coming from the perception and communication technologies both in line-of-sight (LOS) and non-LOS conditions. We establish that the performances of this system are influenced by the classification performances of the perception system and by the accuracy of the GPS positioning transmitted by the communication system.
Does Choosing a Treatment Depend on Making a Diagnosis? US and French Physicians’ Decision Making about Acute Otitis Media

Background . The classic sequential processing model of clinical decision making—in which the treatment choice follows and depends on the diagnostic judgment—may in some cases be replaced by a processing model in which the treatment choice depends on an independent assessment of the diagnostic and other cues. The aim of this study was to determine which processing model would better describe physicians’ treatment choices in a simulated clinical task. Methods . Seventy-five US and French primary care physicians were presented twice, in a different order, with the same set of 46 scenarios of 15-month-old children suspected of having acute otitis media (AOM). They rated in one set the probability of AOM and in the other set whether they would treat the child with antibiotics (and how confident they felt in their decision). Linear regression analyses revealed the individuals’ 2 judgment policies. Hierarchical discriminant analysis was used to analyze the variance explained in the treatment choice by, 1st, the diagnostic judgment, 2nd, the cues specific to treatment, and 3rd, the cues specific to diagnosis. Results . Even when choosing treatment, the participants placed greatest weight on diagnostic cues, especially the ear findings. Only 28% used the cues that reflected parental issues. For 36%, the diagnostic cues had an effect on the treatment choice independent of the effect (if any) of the diagnostic judgment. Conclusion . In deciding how to treat AOM, the majority of the participating US and French primary care physicians followed the classic sequential processing model, but a substantial minority used instead an independent processing model.
Deficit in Motor Training-Induced Clustering, but Not Stabilization, of New Dendritic Spines in fmr1 Knock-Out Mice

Fragile X Syndrome is the most common inherited intellectual disability, and Fragile X Syndrome patients often exhibit motor and learning deficits. It was previously shown that the fmr1 knock-out mice, a common mouse model of Fragile X Syndrome, recapitulates this motor learning deficit and that the deficit is associated with altered plasticity of dendritic spines. Here, we investigated the motor learning-induced turnover, stabilization and clustering of dendritic spines in the fmr1 knock-out mouse using a single forelimb reaching task and in vivo multiphoton imaging. We report that fmr1 knock-out mice have deficits in motor learning-induced changes in dendritic spine turnover and new dendritic spine clustering, but not the motor learning-induced long-term stabilization of new dendritic spines. These results suggest that a failure to establish the proper synaptic connections in both number and location, but not the stabilization of the connections that are formed, contributes to the motor learning deficit seen in the fmr1 knock-out mouse.
Electrophysiological and Electrocardiographic Characteristics of Focal Atrial Tachycardia Originating From the Pulmonary Veins: Acute and Long-Term Outcomes of Radiofrequency Ablation

Background—The objective of this study was to describe the electrophysiological characteristics, anatomic distribution, and long-term outcome after focal ablation (RFA) of pulmonary vein (PV) atrial tachycardia (AT). Both atrial fibrillation (AF) and AT may be due to a rapidly firing focus in the PVs. Whether these represent two aspects of the same process is unknown. Methods and Results—Twenty-seven patients with 28 PV(16%) ATs of a consecutive series of 172 undergoing RFA for focal AT are reported. The mean age was 39±16 years, with symptoms for 9±14 years resistant to 1.7±0.8 medications. AT occurred spontaneously or with isoproterenol in all patients and was not inducible with PES in any. The distribution of PV ATs was right superior PV, 11; left superior PV, 11; left inferior PV, 5; and right inferior PV, 1; 26of 28 foci (93%) were ostial. RFA was successful in 28 of 28 PV ATs acutely. RFA was focal in 25 of 28, with PV isolation of a single target vein in 3. There were 4 recurrences at a mean of 3.3 months. Repeat RFA was performed in all 4 and successful in 3 of 4. All but one recurrence occurred from the same site. Long-term success was achieved in 26 of 27 (96%) patients at mean follow-up of 25±22 months. No patients have had subsequent development of AF or AT from a different site. Conclusions—PV AT has a distribution similar to PV AF, with a propensity to upper veins. However, the majority of foci are ostial, and only a small percentage occur from deep in the PV. Focal RFA is associated with high long-term success, with freedom from both AT from other sites and from AF. PV AT is a localized process and therefore may be different from PV AF.
Comparison of linear precoding schemes for downlink massive MIMO

We consider the downlink of a time-division duplexing (TDD) multicell multiuser MIMO system where the base stations (BSs) are equipped with a very large number of antennas. Assuming channel estimation through uplink pilots, arbitrary antenna correlation and user distributions, we derive approximations of achievable rates with linear precoding techniques, namely eigenbeamforming (BF) and regularized zero-forcing (RZF). The approximations are tight in the large system limit with an infinitely large number of antennas and user terminals (UTs), but match our simulations for realistic system dimensions. We further show that a simple RZF precoding scheme can achieve the same performance as BF with one order of magnitude fewer antennas in both uncorrelated and correlated fading channels.
In Vitro Mean Red Blood Cell Volume Change Induced by Diode Pump Solid State Low-Level Laser of 405 nm

Abstract Objective: This study was conducted to investigate the effects of low-level laser (LLL) doses on human red blood cell volume. The effects of exposure to a diode pump solid state (DPSS) (λ = 405 nm) laser were observed. Background data: The response of human blood to LLL irradiation gives important information about the mechanism of interaction of laser light with living organisms. Materials and methods Blood samples were collected into ethylenediaminetetraacetic acid (EDTA)-containing tubes, and each sample was divided into two equal aliquots, one to serve as control and the other for irradiation. The aliquot was subjected to laser irradiation for 20, 30, 40, or 50 min at a fixed power density of 0.03 W/cm2. Mean cell volume (MCV) and red blood cell (RBC) counts were measured immediately after irradiation using a computerized hemtoanalyzer. Results: Significant decrease in RBC volume (p < 0.05, p < 0.0001, p < 0.0001, and p < 0.05, respectively) was induced with variation in laser doses.The highest response was observed with an exposure time of 40 min. This result was reproduced in RBCs suspended in a buffered NaCl solution. In contrast to this finding, laser-induced RBC volume change was completely abolished by suspending RBCs in a solution containing a higher concentration of EDTA. Conclusions: It was suggested that LLL can reduce RBC volume possibly because of the increased free intracellular Ca+2 concentrations, which activate Ca+2-dependent K+ channels with consequent K+ ion efflux and cell shrinkage.
Systematic Review and Meta-Analysis of the Birth Prevalence of Orofacial Clefts in Low- and Middle-Income Countries

Background In the last comprehensive review of the literature published in 2002, little information on the prevalence of orofacial clefts was available from low- and middle-income countries (LMICs). Objective To analyze published data on the birth prevalence of cleft lip and/or palate (CL/P) from LMIC. Design Systematic review of the literature and meta-analysis of data from original papers on the birth prevalence of cleft lip and/or cleft palate (CL/P) in LMICs between 1990 and 2014. Secondary inclusion criteria were developed to analyze lower-quality studies from countries with scarce data. Main Outcome Measure Birth prevalence of undifferentiated CL/P (with or without associated syndrome or other anomaly). Results Twenty-eight studies met strict inclusion criteria. Among 31,475,278 total births, the pooled birth prevalence of undifferentiated CL/P was 1.38 per 1000 births (95% confidence interval [CI]: 1.20 to 1.56). Four studies met criteria for secondary analysis, providing data on 75,627 births, with a pooled prevalence of 0.75 CL/P cases per 1000 births (95% CI: 0.56 to 0.95). Comparison of studies was limited by variable definitions of cases and of the reference population and by inconsistent reporting of outcomes. There is significant heterogeneity in the findings. Conclusions In LMICs, approximately 1 in every 730 children is born with CL/P. To optimize comparability across settings, future research should use a standard classification system and standard criteria for data collection and presentation. As clefting is associated with deprivation, understanding the true scale, risks, and preventive measures for orofacial clefts in LMIC is a matter of both scientific and humanitarian importance.
Selective Arterial Calcium Stimulation With Hepatic Venous Sampling Differentiates Insulinoma From Nesidioblastosis.

CONTEXT In adult patients with endogenous hyperinsulinemic hypoglycemia and negative or inconclusive noninvasive imaging, insulinoma and non-insulinoma pancreatogenous hypoglycemic syndrome (NIPHS) resulting from diffuse nesidioblastosis must be considered in the differential diagnosis. It is not known whether the biochemical results of selective arterial calcium stimulation (SACST) with hepatic venous sampling can differentiate insulinoma from diffuse nesidioblastosis. OBJECTIVE To determine the specificity of SACST with hepatic venous sampling in differentiating insulinoma from diffuse nesidioblastosis. DESIGN Retrospective review (January 1996 to March 2014). SETTING Tertiary referral center. PATIENTS OR OTHER PARTICIPANTS A total of 116 patients with biochemical evidence of endogenous hyperinsulinemic hypoglycemia and negative or inconclusive noninvasive imaging who were subsequently shown at surgery to have insulinoma (n = 42) or nesidioblastosis (n = 74) after undergoing SACST with hepatic venous sampling. INTERVENTION(S) SACST with hepatic venous sampling before pancreatic exploration. MAIN OUTCOME MEASURE(S) Receiver operating characteristic curves were generated from the biochemical results of SACST to determine the specificity of the maximum hepatic venous insulin concentration (mHVI) and the relative-fold increase in hepatic venous insulin concentration (rHVI) over baseline after calcium injection from the dominant artery in differentiating insulinoma from nesidioblastosis. RESULTS The mHVI (21.5-fold; P < .001) and rHVI (3.9-fold; P < .001) were significantly higher in the insulinoma group compared to the nesidioblastosis group. The areas under the receiver operating characteristic curve for mHVI and rHVI were excellent (0.94; P < .0001) and good (0.83; P < .0001), respectively, for differentiating insulinoma from nesidioblastosis. mHVI cutoffs of > 91.5 and > 263.5 μIU/mL were 95 and 100% specific for insulinoma, respectively. A 19-fold increase in rHVI over baseline was 99% specific for insulinoma. CONCLUSIONS These data suggest that the mHVI and rHVI at SACST may be useful in differentiating insulinoma from nesidioblastosis with high specificity in patients with hyperinsulinemic hypoglycemia and negative or inconclusive noninvasive imaging.
Clonal Diversity of Escherichia coli Colonizing Stools and Urinary Tracts of Young Girls

ABSTRACT Intestinal carriage of Escherichia coli in prepubertal girls without a history of urinary tract infection was examined by collecting weekly stools and periurethral and urine samples over 3 to 4 weeks of study. Dominant and minor clones were defined by grouping 28 E. coli isolates into clonal types. Multiple enteric clones of E. coli, which changed week to week, were found in the 13 girls during the study (median, 3 clones/girl; range, 1 to 16 clones/girl). Dominance of an enteric clone did not predict persistence in the stool. In only 10 (34%) of the 29 episodes in which a dominant clone present in one weekly sample could have been detected the following week did it persist as the dominant clone in the next weekly sample. In 5 (17%) of the 29 episodes, a dominant clone found in one weekly sample was classified as a minor clone the next week. Both dominant and minor clones were observed to colonize the urinary tract. However, when colonization of the periurethra or bladder urine occurred, it was brief and often did not reflect the dominant stool flora from the same week. In fact, in only 40% of episodes was a clone that was detected either on the periurethra or in the urine also recovered from the stool the same week. Our findings suggest that the intestinal flora of healthy girls is multiclonal with frequent fluctuations in composition.
On building general modular adders from standard binary arithmetic components

We introduce an excess-δ residue representation for residue number system (RNS) arithmetic, in which a flag bit selects one or the other subrange within the full range of n-bit values. We show that our new representation leads to simple modular arithmetic with arbitrary residues, while using standard arithmetic components such as carry-save and carry-propagate adders that have been extensively optimized for area, power, and a host of other composite figures of merit. Further advantages of a unified treatment, as opposed to a multiplicity of specialized schemes previously proposed in connection with particular classes of moduli such as 2n ± 1 and 2n − 2k ± 1, includesimplified design process, verification, testing, and fault tolerance. Both gate-level analyses and VLSI synthesis results point to advantagesin latency, area, and/or power compared with other proposed designs in the literature.
Integrative Analysis of Normal Long Intergenic Non-Coding RNAs in Prostate Cancer

Recently, large numbers of normal human tissues have been profiled for non-coding RNAs and more than fourteen thousand long intergenic non-coding RNAs (lincRNAs) are found expressed in normal human tissues. The functional roles of these normal lincRNAs (nlincRNAs) in the regulation of protein coding genes in normal and disease biology are yet to be established. Here, we have profiled two RNA-seq datasets including cancer and matched non-neoplastic tissues from 12 individuals from diverse demography for both coding genes and nlincRNAs. We find 130 nlincRNAs significantly regulated in cancer, with 127 regulated in the same direction in the two datasets. Interestingly, according to Illumina Body Map, significant numbers of these nlincRNAs display baseline null expression in normal prostate tissues but are specific to other tissues such as thyroid, kidney, liver and testis. A number of the regulated nlincRNAs share loci with coding genes, which are either co-regulated or oppositely regulated in all cancer samples studied here. For example, in all cancer samples i) the nlincRNA, TCONS_00029157, and a neighboring tumor suppressor factor, SIK1, are both down regulated; ii) several thyroid-specific nlincRNAs in the neighborhood of the thyroid-specific gene TPO, are both up-regulated; and iii) the TCONS_00010581, an isoform of HEIH, is down-regulated while the neighboring EZH2 gene is up-regulated in cancer. Several nlincRNAs from a prostate cancer associated chromosomal locus, 8q24, are up-regulated in cancer along with other known prostate cancer associated genes including PCAT-1, PVT1, and PCAT-92. We observe that there is significant bias towards up-regulation of nlincRNAs with as high as 118 out of 127 up-regulated in cancer, even though regulation of coding genes is skewed towards down-regulation. Considering that all reported cancer associated lincRNAs (clincRNAs) are biased towards up-regulation, we conclude that this bias may be functionally relevant.
To connect or not to connect: experiences from modeling topological variability

Variability management aims at taming variability in large and complex software product lines. To efficiently manage variability, it has to be modeled using formal representations, such as feature or decision models. Such models are efficient in many domains, where variability is about switching on and off features, or using parameters to customize products of the product line. However, variability can be represented in the form of a topology in domains where variability is about connecting components in a certain order, in specific interconnected hierarchies, or in different quantities. In this experience report, we explore topological variability within a case study of large-scale fire alarm systems. We identify core characteristics of the variability, derive modeling requirements, model the variability using UML2 class diagrams, and discuss the applicability of further variability modeling languages. We show that, although challenging, class diagrams can suffice to represent topological variability in order to generate a configurator tool. In contrast, modeling parallel and recursive structures, cycles, informal constraints, and orthogonal hierarchies were among the main experienced challenges that require further research.
Cleanup of trimethylamine (fishy odor) from contaminated air by various species of Sansevieria spp. and their leaf materials

ABSTRACT Removal of trimethylamine (TMA) by 10 different living Sansevieria spp. and their dried leaf materials was studied. The results showed that living Sansevieria kirkii was the most effective plant while Sansevieria masoniana was the least effective in TMA removal. Two major pathways were involved in stomata opening and epicuticular wax on the leaf surface. In the presence of TMA, the stomata opening in Sansevieria spp. was induced, which enhanced TMA removal under light conditions. Dried leaf powders of Sansevieria spp. adsorbed TMA through their waxes. Therefore, both living and non-living Sansevieria spp. can be effectively used for removal of TMA.