Miracle-dz/UniFAR-FTUs huggingface dataset:
Improvement in 3-Month Patient-Reported Gastrointestinal Symptoms After Conversion From Mycophenolate Mofetil to Enteric-Coated Mycophenolate Sodium in Renal Transplant Patients

Background. The benefit of conversion from mycophenolate mofetil (MMF) to enteric-coated mycophenolate sodium (EC-MPS) in terms of gastrointestinal symptom burden has been evaluated previously using patient-reported outcomes. However, data are lacking concerning the sustained effect of conversion over time, and the potential impact of concomitant calcineurin inhibitor. Methods. In this 3-month, prospective, multicenter, longitudinal, open-label trial, MMF-treated renal transplant patients with gastrointestinal symptoms receiving cyclosporine or tacrolimus were converted to equimolar doses of EC-MPS. Change in gastrointestinal symptom burden was evaluated using a validated Gastrointestinal Symptom Rating Scale (GSRS). Results. A significant improvement in GSRS score was observed from baseline (2.61, 95% CI 2.54–2.68) to month 1 (1.87, 95% CI 1.81–1.93) after conversion to EC-MPS and was sustained to month 3 (1.81, 95% CI 1.74–188; both P<0.0001 versus baseline). The mean change in overall GSRS score from baseline to month 1 was −0.74 overall (cyclosporine: −0.73 and tacrolimus: −0.74; all P<0.0001 versus baseline), with a slight further improvement (−0.79) at month 3 (cyclosporine: −0.82 and tacrolimus: −0.78; all P<0.0001 versus baseline). A significant improvement in GSRS subscale scores was also observed in the total population regardless of calcineurin inhibitor at month 1, sustained to month 3 (all P<0.0001 versus baseline). The improvement in GSRS score postconversion was similar in African-American and non-African-American patients, and in diabetic and nondiabetic patients. Conclusions. This exploratory study in 728 patients demonstrates that following conversion from MMF to EC-MPS, regardless of concomitant calcineurin inhibitor, GSRS is improved and sustained over 3 months.
Frontiers in Computational Neuroscience 2 Methods 2.1 Visual Stimuli and Task

it difficult to gauge small discrepancies from ideal choice behavior. As a result, ideal and MAX models are often equally applicable to human vision (Pelli, 1985; Cohn and Lasley, 1986). Furthermore it has proven challenging to decide whether an alternative model may be more appropriate than these two, as most simulated observers make similar predictions in terms of standard detectability metrics in relation to a number of important topics in visual detection, e.g., quantum efficiency (Cohn and Lasley, 1986), Birdsall's linearization (pertaining to the impact of internal noise on signal transduc-tion; Klein and Levi, 2009), dipper effects (the non-monotonic behavior of some sensory threshold characteristics Solomon, 2009), stochastic-resonance-like phenomena (Perez et al., 2007). A possible route to resolving this empirical issue may be to employ experimental techniques that allow a more detailed characterization of the underlying process than detectability metrics The introduction of reverse correlation methodolo-gies into visual psychophysics (whereby noisy perturbations of the input stimulus are linked to the resulting behavioral responses) has offered an attractive tool of this kind: psychophysical reverse correlation allows retrieval of the perceptual template used by the human observer to perform certain tasks under specific stimulus conditions (Ahumada, 2002) and has been successfully applied to a range of problems in human vision (Victor, 2005; Neri and Levi, 2006). However it is not obvious that this technique would help to clarify the issue of interest here, because it suffers from the significant limitation that its properties are well understood only under certain assumptions about the detection process, in particular that it conforms to a linear template followed by a decisional rule (Ahumada, 2002; Murray et al., 2005). Uncertainty represents a 1 IntroductIon There are virtually no situations, whether in the laboratory or in the natural environment, when the human visual system has exact knowledge of all aspects concerning the task at hand Even in highly artificial and specified conditions, human observers behave as though they are uncertain about some aspects of the visual stim-Uncertainty is pervasive to all forms of visual processing, from the simplest visual detection task to the more complex recognition task. Its relevance was emphasized with distinct clarity over 20 years ago by a landmark article (Pelli, 1985) in which Pelli described how the concept of uncertainty, instantiated by a MAX model, could lead to important insights into various aspects of visual processing. If the template filter used by the model is …
Age Distribution of Influenza Like Illness Cases during Post-Pandemic A(H3N2): Comparison with the Twelve Previous Seasons, in France

In France, the 2011–2012 influenza epidemic was characterized by the circulation of antigenically drifted influenza A(H3N2) viruses and by an increased disease severity and mortality among the elderly, with respect to the A(H1N1)pdm09 pandemic and post-pandemic outbreaks. Whether the epidemiology of influenza in France differed between the 2011–2012 epidemic and the previous outbreaks is unclear. Here, we analyse the age distribution of influenza like illness (ILI) cases attended in general practice during the 2011–2012 epidemic, and compare it with that of the twelve previous epidemic seasons. Influenza like illness data were obtained through a nationwide surveillance system based on sentinel general practitioners. Vaccine effectiveness was also estimated. The estimated number of ILI cases attended in general practice during the 2011–2012 was lower than that of the past twelve epidemics. The age distribution was characteristic of previous A(H3N2)-dominated outbreaks: school-age children were relatively spared compared to epidemics (co-)dominated by A(H1N1) and/or B viruses (including the 2009 pandemic and post-pandemic outbreaks), while the proportion of adults over 30 year-old was higher. The estimated vaccine effectiveness (54%, 95% CI (48, 60)) was in the lower range for A(H3N2) epidemics. In conclusion, the age distribution of ILI cases attended in general practice seems to be not different between the A(H3N2) pre-pandemic and post-pandemic epidemics. Future researches including a more important number of ILI epidemics and confirmed virological data of influenza and other respiratory pathogens are necessary to confirm these results.
Fast Power- and Slew-Aware Gated Clock Tree Synthesis

Clock tree synthesis plays an important role on the total performance of chip. Gated clock tree is an effective approach to reduce the dynamic power usage. In this paper, two novel gated clock tree synthesizers, power-aware clock tree synthesizer (PACTS) and power- and slew-aware clock tree synthesizer (PSACTS), are proposed with zero skew achieved based on Elmore RC model. In PACTS, the topology of the clock tree is constructed with simultaneous buffer/gate insertion, which reduces the switched capacitance. In PSACTS, a more practical clock slew constraint is applied. Compared to previous works, clock tree synthesis is done first and followed by the insertions of clock gates. The clock slew changes a lot after the insertions of clock gates in real cases. In our work, the clock tree is constructed simultaneously with the insertions of clock gates. This ensures the limitation of the clock slew can be strictly satisfied while the limitation of the clock slew is always applied in the real design. The experimental results show that the power cost of our work is smaller and the runtime is reduced. The slew rate constraint is satisfied with a small clock skew from SPICE estimation. Generally, our work has better performance, improved efficiency and is more practical to be applied in the industry.
Rapid measurement of whole body and forearm protein turnover using a [2H5]phenylalanine model.

Whole body protein turnover was measured in six normal adults using a model based on a primed constant infusion of [2H5]phenylalanine and, independently, by an established method of a primed constant infusion of [1-13C]leucine. Isotopic plateau in plasma was achieved within 2 h for [2H5]phenylalanine and, in four of the subjects who received a priming dose of [2H4]tyrosine, for [2H4]tyrosine. In all subjects whole body protein turnover measured with the phenylalanine model (mean protein synthesis, 2.65 +/- (SD) 0.16 g.kg-1.24 h-1; catabolism, 3.58 +/- 0.26 g.kg-1.24 h-1) was similar to that measured using the leucine model (synthesis, 3.09 +/- 0.27 g.kg-1.24 h-1; catabolism, 3.70 +/- 0.35 g.kg-1.24 h-1). Mean forearm fractional muscle protein synthesis calculated by the phenylalanine model was 0.06 +/- 0.03%/h, which compares closely with literature values derived by other methods. The phenylalanine model allows the rapid assessment of whole body and muscle protein turnover from plasma samples alone, obviating the need for measurement of expired air CO2 production or enrichment.
Successful treatment of resistant alopecia areata with a phototoxic dose of ultraviolet A after topical 8‐methoxypsoralen application

Background: The efficacy of a phototoxic dose of ultraviolet A (UVA) after topical application of 8‐methoxypsoralen (8‐MOP) in the treatment of alopecia areata (AA) was evaluated previously in only one study. However, the possibility of spontaneous regrowth of hair cannot be excluded as sessions were carried out every 3 months.
Microbial Population Analysis of the Salivary Glands of Ticks; A Possible Strategy for the Surveillance of Bacterial Pathogens

Ticks are one of the most important blood-sucking vectors for infectious microorganisms in humans and animals. When feeding they inject saliva, containing microbes, into the host to facilitate the uptake of blood. An understanding of the microbial populations within their salivary glands would provide a valuable insight when evaluating the vectorial capacity of ticks. Three tick species (Ixodes ovatus, I. persulcatus and Haemaphysalis flava) were collected in Shizuoka Prefecture of Japan between 2008 and 2011. Each tick was dissected and the salivary glands removed. Bacterial communities in each salivary gland were characterized by 16S amplicon pyrosequencing using a 454 GS-Junior Next Generation Sequencer. The Ribosomal Database Project (RDP) Classifier was used to classify sequence reads at the genus level. The composition of the microbial populations of each tick species were assessed by principal component analysis (PCA) using the Metagenomics RAST (MG-RAST) metagenomic analysis tool. Rickettsia-specific PCR was used for the characterization of rickettsial species. Almost full length of 16S rDNA was amplified in order to characterize unclassified bacterial sequences obtained in I. persulcatus female samples. The numbers of bacterial genera identified for the tick species were 71 (I. ovatus), 127 (I. persulcatus) and 59 (H. flava). Eighteen bacterial genera were commonly detected in all tick species. The predominant bacterial genus observed in all tick species was Coxiella. Spiroplasma was detected in Ixodes, and not in H. flava. PCA revealed that microbial populations in tick salivary glands were different between tick species, indicating that host specificities may play an important role in determining the microbial complement. Four female I. persulcatus samples contained a high abundance of several sequences belonging to Alphaproteobacteria symbionts. This study revealed the microbial populations within the salivary glands of three species of ticks, and the results will contribute to the knowledge and prediction of emerging tick-borne diseases.
Continuity in Multi-Device Interaction: An Online Study

Techniques for multi-device interactions are finding their way into commercial products. This means that people are now exposed to possibilities of interacting with and across their devices, and this presents a valuable opportunity for studying their uptake and use in real life. In this paper we investigate and discuss the emerging multi-device interaction concept of "continuity", which allow an activity to begin on one device and continue on another. We present a study of the challenges people have experienced in the use of a specific new product offering such functionality, namely Apple's Continuity. The study was done through surveying 3361 posts from technology web sites, discussion forums, and blogs, with a qualitative analysis of 1603 posts. Our findings present challenges in six themes of privacy, appropriation, customization, awareness, exclusion, and troubleshooting in relation to continuous interaction across devices. We further discuss the high-level implications of our findings through four design considerations for continuity in multi-device interaction.
Characterization and imaging in optically scattering media by use of laser speckle and a variable-coherence source.

We demonstrate the application of laser-speckle statistics formed by a variable-coherence source illuminating a scattering medium, for determining the scattering parameter mu;(s)>(? ) of a diffusion model for the medium. Furthermore, we apply this technique to visualize laterally localized inhomogeneities embedded within a highly scattering sample.
Network Coding Theory: A Survey

This article surveys all known fields of network coding theory and leads the reader through the antecedents of the network coding theory to the most recent results, considering also information theory and matroid theory. By focusing on providing ideas and not formulas, this survey is both fitted for the taste of readers who are mathematically oriented and newcomers to the area. Additionally, this survey also includes an innovative and clear graph representation of the most prominent literature on network coding theory, its relevance and evolution from the very beginning till today.
Reconstitution of the ATP-sensitive potassium channel of skeletal muscle. Activation by a G protein-dependent process

Potassium channels inhibited by adenosine-5'-trisphosphate, K(ATP), found in the transverse tubular membrane of rabbit skeletal muscle were studied using the planar bilayer recording technique. In addition to the single-channel properties of K(ATP) we report its regulation of Mg2+ and by the guanosine-5'-trisphosphate analogue, GTP-y(gamma)-S. The K(ATP) channel (a) has a conductance of 67 pS in 250 mM internal, 50 mM external KCl, and rectifies weakly at holding potentials more positive than 50 mV, (b) is not activated by internal Ca2+ or membrane depolarization, (c) has a permeability ratio PK/PNa greater than 50, and (d) is inhibited by millimolar internal ATP. Activity of K(ATP), measured as open channel probability as a function of time, was unstable at all holding potentials and decreases continuously within a few minutes after a recording is initiated. After a decrease in activity, GTP-y-S (100 microM) added to the internal side reactivated K(ATP) channels but only transiently. In the presence of internal 1 mM Mg2+, GTP-y-S produced a sustained reactivation lasting 20-45 min. Incubation of purified t-tubule vesicles with AlF4 increased the activity of K(ATP) channels, mimicking the effect of GTP-y-S. The effect of AlF4 and the requirement of GTP-y-S plus Mg2+ for sustained channel activation suggests that a nucleotide-binding G protein regulates ATP-sensitive K channels in the t-tuble membrane of rabbit skeletal muscle.
Homeopathic treatment of acute childhood diarrhea: results from a clinical trial in Nepal.

OBJECTIVE To investigate whether the finding in a previous study that homeopathic medicines decrease the duration of acute diarrhea in children could be replicated in a different study population. DESIGN Randomized, double-blind, placebo-controlled trial. SETTING Private, charitable health clinic in Kathmandu, Nepal. SUBJECTS A consecutive sample of 126 children, 6 months to 5 years of age, who presented during April through June, 1994, with more than three unformed stools in the previous 24 hours. INTERVENTION Children received either an individualized homeopathic medicine or placebo, to be taken one dose after each unformed stool for 5 days. Parents recorded daily stools on diary cards, and health workers made home visits daily to monitor children. OUTCOME MEASURES Predefined measures were based on the previous study: (1) duration of diarrhea, defined as the time until there were fewer than three unformed stools per day, for two consecutive days, and (2) Average number of stools per day for each group. RESULTS Of the 126 children initially enrolled, 116 completed treatment. The mean number of stools per day over the entire 5-day treatment period was 3.2 for the treatment group and 4.5 for the placebo group (P = 0.023). A Kaplan-Meier survival analysis of the duration of diarrhea, which included data from all patient visits, showed an 18.4% greater probability that a child would be free of diarrhea by day 5 under homeopathic treatment (P = 0.036). CONCLUSIONS These results are consistent with the finding from the previous study that individualized homeopathic treatment decreases the duration of diarrhea and number of stools in children with acute childhood diarrhea.
Vicariance divergence and gene flow among islet populations of an endemic lizard

Allopatry and allopatric speciation can arise through two different mechanisms: vicariance or colonization through dispersal. Distinguishing between these different allopatric mechanisms is difficult and one of the major challenges in biogeographical research. Here, we address whether allopatric isolation in an endemic island lizard is the result of vicariance or dispersal. We estimated the amount and direction of gene flow during the divergence of isolated islet populations and subspecies of the endemic Skyros wall lizard Podarcis gaigeae, a phenotypically variable species that inhabits a major island and small islets in the Greek archipelago. We applied isolation‐with‐migration models to estimate population divergence times, population sizes and gene flow between islet–mainland population pairs. Divergence times were significantly correlated with independently estimated geological divergence times. This correlation strongly supports a vicariance scenario where islet populations have sequentially become isolated from the major island. We did not find evidence for significant gene flow within P. g. gaigeae. However, gene‐flow estimates from the islet to the mainland populations were positively affected by islet area and negatively by distance between the islet and mainland. We also found evidence for gene flow from one subspecies (P. g. weigandi) into another (P. g. gaigeae), but not in the other direction. Ongoing gene flow between the subspecies suggests that even in this geographically allopatric scenario with the sea posing a strong barrier to dispersal, divergence with some gene flow is still feasible.
Moringa oleifera Supplemented Diets Prevented Nickel-Induced Nephrotoxicity in Wistar Rats

Background. The Moringa oleifera plant has been implicated for several therapeutic potentials. Objective. To evaluate whether addition of M. oleifera to diet has protective effect against nickel-induced nephrotoxicity in rats. Methodology. Male Wistar rats were assigned into six groups of five. The rats were given oral exposure to 20 mg/kg nickel sulphate (NiSO4) in normal saline and sustained on either normal diet or diets supplemented with Moringa oleifera at different concentrations for 21 days. 24 hours after cessation of treatments, all animals were sacrificed under slight anesthesia. The blood and kidney samples were collected for biochemical and histopathology analyses, respectively. Results. NiSO4 exposure reduced the kidney-to-body weight ratio in rats and caused significant elevation in the levels of plasma creatinine, urea, and potassium. Also, the plasma level of sodium was decreased by NiSO4 exposure. However, addition of M. oleifera to diets averted the nickel-induced alteration to the level of creatinine and urea. The histopathology revealed damaged renal tubules and glomerular walls caused by NiSO4 exposure. In contrast, the damages were ameliorated by the M. oleifera supplemented diets. Conclusion. The addition of M. oleifera to diet afforded significant protection against nickel-induced nephrotoxicity.
Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy

Purpose: Paclitaxel is used worldwide in the treatment of breast, lung, ovarian, and other cancers. Sensory peripheral neuropathy is an associated adverse effect that cannot be predicted, prevented, or mitigated. To better understand the contribution of germline genetic variation to paclitaxel-induced peripheral neuropathy, we undertook an integrative approach that combines genome-wide association study (GWAS) data generated from HapMap lymphoblastoid cell lines (LCL) and Asian patients. Methods: GWAS was performed with paclitaxel-induced cytotoxicity generated in 363 LCLs and with paclitaxel-induced neuropathy from 145 Asian patients. A gene-based approach was used to identify overlapping genes and compare with a European clinical cohort of paclitaxel-induced neuropathy. Neurons derived from human-induced pluripotent stem cells were used for functional validation of candidate genes. Results: SNPs near AIPL1 were significantly associated with paclitaxel-induced cytotoxicity in Asian LCLs (P < 10−6). Decreased expression of AIPL1 resulted in decreased sensitivity of neurons to paclitaxel by inducing neurite morphologic changes as measured by increased relative total outgrowth, number of processes and mean process length. Using a gene-based analysis, there were 32 genes that overlapped between Asian LCL cytotoxicity and Asian patient neuropathy (P < 0.05), including BCR. Upon BCR knockdown, there was an increase in neuronal sensitivity to paclitaxel as measured by neurite morphologic characteristics. Conclusions: We identified genetic variants associated with Asian paclitaxel-induced cytotoxicity and functionally validated the AIPL1 and BCR in a neuronal cell model. Furthermore, the integrative pharmacogenomics approach of LCL/patient GWAS may help prioritize target genes associated with chemotherapeutic-induced peripheral neuropathy. Clin Cancer Res; 21(19); 4337–46. ©2015 AACR.
Numerical simulations of isothermal flow in a swirl burner

In this paper, the non-reacting flow in a swirl burner is studied using large eddy simulation. The configuration consists of two unconfined coannular jets at a Reynolds number of 81,500. The flow is characterized by a Swirl number of 0.93. Two cases are studied in the paper differing with respect to the axial location of the inner pilot jet. It was observed in a companion experiment (Bender and Buchner, 2005, Proc. 12 Int. Cong. Sound and Vibration, Lisbon, Portugal) that when the inner jet is retracted the flow oscillations are considerably amplified. This is also found in the present simulations. Large-scale coherent structures rotating at a constant rate are observed when the inner jet is retracted. The rotation of the structures leads to vigorous oscillations in the velocity and pressure time signals recorded at selected points in the flow. In addition, the mean velocities, the turbulent fluctuations, and the frequency of the oscillations are in good agreement with the experiments. A conditional averaging procedure is used to perform a detailed analysis of the physics leading to the low-frequency oscillations.