Miracle-dz/UniFAR-FTUs huggingface dataset:
Toward Streaming Synapse Detection with Compositional ConvNets

Connectomics is an emerging field in neuroscience that aims to reconstruct the 3-dimensional morphology of neurons from electron microscopy (EM) images. Recent studies have successfully demonstrated the use of convolutional neural networks (ConvNets) for segmenting cell membranes to individuate neurons. However, there has been comparatively little success in high-throughput identification of the intercellular synaptic connections required for deriving connectivity graphs. In this study, we take a compositional approach to segmenting synapses, modeling them explicitly as an intercellular cleft co-located with an asymmetric vesicle density along a cell membrane. Instead of requiring a deep network to learn all natural combinations of this compositionality, we train lighter networks to model the simpler marginal distributions of membranes, clefts and vesicles from just 100 electron microscopy samples. These feature maps are then combined with simple rules-based heuristics derived from prior biological knowledge. Our approach to synapse detection is both more accurate than previous state-of-the-art (7% higher recall and 5% higher F1-score) and yields a 20-fold speed-up compared to the previous fastest implementations. We demonstrate by reconstructing the first complete, directed connectome from the largest available anisotropic microscopy dataset (245 GB) of mouse somatosensory cortex (S1) in just 9.7 hours on a single shared-memory CPU system. We believe that this work marks an important step toward the goal of a microscope-pace streaming connectomics pipeline.
Could a B-1 Cell Derived Phagocyte “Be One” of the Peritoneal Macrophages during LPS-Driven Inflammation?

The inflammatory response is driven by signals that recruit and elicit immune cells to areas of tissue damage or infection. The concept of a mononuclear phagocyte system postulates that monocytes circulating in the bloodstream are recruited to inflamed tissues where they give rise to macrophages. A recent publication demonstrated that the large increase in the macrophages observed during infection was the result of the multiplication of these cells rather than the recruitment of blood monocytes. We demonstrated previously that B-1 cells undergo differentiation to acquire a mononuclear phagocyte phenotype in vitro (B-1CDP), and we propose that B-1 cells could be an alternative origin for peritoneal macrophages. A number of recent studies that describe the phagocytic and microbicidal activity of B-1 cells in vitro and in vivo support this hypothesis. Based on these findings, we further investigated the differentiation of B-1 cells into phagocytes in vivo in response to LPS-induced inflammation. Therefore, we investigated the role of B-1 cells in the composition of the peritoneal macrophage population after LPS stimulation using osteopetrotic mice, BALB/Xid mice and the depletion of monocytes/macrophages by clodronate treatment. We show that peritoneal macrophages appear in op/op(−/−) mice after LPS stimulation and exhibit the same Ig gene rearrangement (VH11) that is often found in B-1 cells. These results strongly suggest that op/op(−/−) peritoneal “macrophages” are B-1CDP. Similarly, the LPS-induced increase in the macrophage population was observed even following monocyte/macrophage depletion by clodronate. After monocyte/macrophage depletion by clodronate, LPS-elicited macrophages were observed in BALB/Xid mice only following the transfer of B-1 cells. Based on these data, we confirmed that B-1 cell differentiation into phagocytes also occurs in vivo. In conclusion, the results strongly suggest that B-1 cell derived phagocytes are a component of the LPS-elicited peritoneal macrophage population.
Profiles of Peritraumatic Emotions

ABSTRACT Researchers have identified peritraumatic emotions as important predictors of who will develop posttraumatic stress disorder (PTSD) symptoms. However, such investigations have not examined full profiles of emotions, perhaps because of the typical emphasis on fear or other Criterion A2 emotions. Such an examination could help us identify which peritraumatic emotions are prominent, and how they relate to important posttrauma outcomes. Thus, the aim of this study was to identify distinct profiles of peritraumatic emotions and their correlates using a comprehensive survey of peri- and posttraumatic reactions. We conducted a latent profile analysis of peritraumatic emotions in 398 undergraduate students who reported a DSM–IV A1 trauma and then compared the resulting profiles on trauma type, PTSD, depression, and posttraumatic cognitions. Six distinct profiles emerged: 3 had consistently low, medium, or high levels across the range of emotions, with 3 others primarily characterized by low shame and guilt, high anger and guilt, and low guilt. These profiles significantly differed in terms of trauma type, PTSD, depression, and posttraumatic cognitions. In particular, profiles with high levels of anger, shame, and guilt were consistently related to overall worse functioning. Importantly, fear and associated emotions did not differentiate between profiles. These results have important implications for the phenomenology of posttrauma emotional reactions and strongly suggest that the clinical assessment of traumatic experiences go beyond fear-based conceptualizations.
The Implementation of Character Education Model at Islamic Boarding School of Pabelan, Magelang, Central Java

This research was conducted at Islamic Boarding School of Pabelan, Central Java. Here, character education model was delivered to students through role modelling method and formalizing into routines which were implemented since KH. Hamam Dja’far era until now. The implementation of character education developed and taught by Kiai Hamam, as a role model, at that time included model of social caring, direct learning, simplicity, educating humanely, education through role modelling, scientific culture model, development of local wisdom or culture, education development, work ethic, and self-reliance. Then, character values emphasized to student are discipline, work ethic, self-reliance, social caring, spirituality and responsibility.
A Data Fusion Technique for Wireless Ranging Performance Improvement

The increasing diffusion of mobile and portable devices provided with wireless connectivity makes the problem of distance measurement based on radio-frequency technologies increasingly important for the development of next-generation nomadic applications. In this paper, the performance limitations of two classic wireless ranging techniques based on received signal strength (RSS) and two-way time-of-flight (ToF) measurements, respectively, are analyzed and compared in detail. On the basis of this study, a data fusion algorithm is proposed to combine both techniques in order to improve ranging accuracy. The algorithm has been implemented and tested on the field using a dedicated embedded prototype made with commercial off-the-shelf components. Several experimental results prove that the combination of both techniques can significantly reduce measurement uncertainty. The results obtained with the developed prototype are not accurate enough for fine-grained position tracking in Ambient Assisted Living applications. However, the platform can be successfully used for reliable indoor zoning, e.g., for omnidirectional and adjustable hazard proximity detection. Most importantly, the proposed solution is absolutely general, and it is quite simple and light from the computational point of view. Accuracy could be further improved by using a more isotropic antenna and by integrating the ToF measurement technique at the lowest possible level on the same radio chip used for communication. Usually, this feature is not available in typical low-cost short-range wireless modules, e.g., for wireless sensor networks. Thus, the results of this research suggest that combining RSS with ToF measurements could be a viable solution for chip manufacturers interested in adding ranging capabilities to their radio modules.
The frequency of the dyadic influence tactics according to communication media

One of the most important determinants of managerial effectiveness in achieving organisational objectives is the success in influencing subordinates, lateral peers and supervisors through influence tactics. However, little attention has been paid to the use of a communication medium in the context of influence tactics. Our objective is to study the frequency of these dyadic influence tactics on diverse communication media. The study involves a questionnaire-based survey conducted on Spanish post-graduate students who had been working in medium-sized or large companies during the last 2 years or more. The results suggest that the richness of the medium explains most similarities and differences in the frequency of influence tactics for different communication media. Furthermore, in the study of hard influence tactics in communication media with similar richness, it is necessary to introduce social aspects and the level of surveillance in order to explain it fully. This study helps managers to understand the relationships between influence tactics and the use of communication media in order to improve their communication effectiveness.
Comparison of buffet and à la carte serving at worksite canteens on nutrient intake and fruit and vegetable consumption

Abstract Objective To evaluate the nutritional composition of worksite canteen lunches and to examine the impact of two meal serving systems on employee intake, i.e. buffet style with a fixed price for a varied number of dishes and à la carte style with a separate price for each item on the menu. Design Laboratory technicians observed employees' food selection and collected identical dishes. Food items were weighed separately to calculate the content of fruit and vegetables. The content of protein, fat and ash of each dish was chemically analysed and the carbohydrate and energy content calculated. Setting Fifteen randomly chosen worksite canteens in Denmark: eight canteens serving buffet style and seven canteens with an à la carte line. Subjects one hundred and eighty randomly chosen employees having lunch at the worksite canteens. Results The average percentage energy from fat was 37 ± 12 among men and 33 ± 12 among women. No association was found between the meal serving system and energy intake or macronutrient composition. Eating at canteens serving buffet style, on the other hand, was associated with an increased intake of fruit and vegetables, on average 76 g, and a lower energy density of the food for both genders. Conclusion The results highlight the possibilities of promoting healthy food choices in the catering sector and the need to identify models of healthy catering practice. Serving buffet style appears to be a promising strategy in order to increase fruit and vegetable consumption in food served away from home.
Ethnic Differences in the Prevalence of Diabetic Retinopathy in Persons With Diabetes When First Presenting at a Diabetes Clinic in South Africa

OBJECTIVE To describe the prevalence and associated risk factors for diabetic retinopathy (DR) within a multiethnic population at presentation to a diabetes clinic in South Africa. RESEARCH DESIGN AND METHODS Retinal photography was conducted using a nonmydriatic digital camera without mydriasis and graded by one of three senior graders. Logistic regression analyses were used to assess the association between any DR, referable DR, and clinical risk factors. RESULTS A total of 1,537 persons with type 1 and 3,978 with type 2 diabetes were included. Prevalence of any DR in type 1 diabetes was 35.2% (background DR 26% and referable DR 9.2%) and in type 2 diabetes was 20.5% (14.1 and 6.4%, respectively). In type 1 diabetes, there was an increased risk of any DR in Asian Indians, whereas the risk of referable DR was increased for indigenous Africans compared with Caucasians. In type 2 diabetes, the risk was increased for all non-Caucasians compared with Caucasians. Longer duration of diabetes and elevated HbA1c were independently associated with any and referable DR in both type 1 and type 2 diabetes, with the addition of hypertension and smoking in type 1 diabetes when adjusted for age at diagnosis of diabetes, sex, and ethnicity. CONCLUSIONS The prevalence of DR in this population from South Africa was similar to that reported globally; however, ethnic differences were observed. Increasing duration of diabetes and poor glycemic control were the strongest risk factors associated with any and referable DR in both type 1 and type 2 diabetes.
Are there alternative adaptive strategies to human pro-sociality? The role of collaborative morality in the emergence of personality variation and autistic traits

ABSTRACT Selection pressures to better understand others’ thoughts and feelings are seen as a primary driving force in human cognitive evolution. Yet might the evolution of social cognition be more complex than we assume, with more than one strategy towards social understanding and developing a positive pro-social reputation? Here we argue that social buffering of vulnerabilities through the emergence of collaborative morality will have opened new niches for adaptive cognitive strategies and widened personality variation. Such strategies include those that that do not depend on astute social perception or abilities to think recursively about others’ thoughts and feelings. We particularly consider how a perceptual style based on logic and detail, bringing certain enhanced technical and social abilities which compensate for deficits in complex social understanding could be advantageous at low levels in certain ecological and cultural contexts. ‘Traits of autism’ may have promoted innovation in archaeological material culture during the late Palaeolithic in the context of the mutual interdependence of different social strategies, which in turn contributed to the rise of innovation and large scale social networks.
Conformation transitions of eukaryotic polyribosomes during multi-round translation

Using sedimentation and cryo electron tomography techniques, the conformations of eukaryotic polyribosomes formed in a long-term cell-free translation system were analyzed over all the active system lifetime (20–30 translation rounds during 6–8 h in wheat germ extract at 25°C). Three distinct types of the conformations were observed: (i) circular polyribosomes, varying from ring-shaped forms to circles collapsed into double rows, (ii) linear polyribosomes, tending to acquire planar zigzag-like forms and (iii) densely packed 3D helices. At the start, during the first two rounds of translation mostly the circular (ring-shaped and double-row) polyribosomes and the linear (free-shaped and zigzag-like) polyribosomes were formed (‘juvenile phase’). The progressive loading of the polyribosomes with translating ribosomes induced the opening of the circular polyribosomes and the transformation of a major part of the linear polyribosomes into the dense 3D helices (‘transitional phase’). After 2 h from the beginning (about 8–10 rounds of translation) this compact form of polyribosomes became predominant, whereas the circular and linear polyribosome fractions together contained less than half of polysomal ribosomes (‘steady-state phase’). The latter proportions did not change for several hours. Functional tests showed a reduced translational activity in the fraction of the 3D helical polyribosomes.
Vaccinating Italian infants with a new multicomponent vaccine (Bexsero®) against meningococcal B disease: A cost-effectiveness analysis

ABSTRACT The European Medicines Agency has approved a multicomponent serogroup B meningococcal vaccine (Bexsero®) for use in individuals of 2 months of age and older. A cost-effectiveness analysis (CEA) from the societal and Italian National Health Service perspectives was performed in order to evaluate the impact of vaccinating Italian infants less than 1 y of age with Bexsero®, as opposed to non-vaccination. The analysis was carried out by means of Excel Version 2011 and the TreeAge Pro® software Version 2012. Two basal scenarios that differed in terms of disease incidence (official and estimated data to correct for underreporting) were considered. In the basal scenarios, we considered a primary vaccination cycle with 4 doses (at 2, 4, 6 and 12 months of age) and 1 booster dose at the age of 11 y, the societal perspective and no cost for death. Sensitivity analyses were carried out in which crucial variables were changed over probable ranges. In Italy, on the basis of official data on disease incidence, vaccination with Bexsero® could prevent 82.97 cases and 5.61 deaths in each birth cohort, while these figures proved to be three times higher on considering the estimated incidence. The results of the CEA showed that the Incremental Cost Effectiveness Ratio (ICER) per QALY was €109,762 in the basal scenario if official data on disease incidence are considered and €26,599 if estimated data are considered. The tornado diagram indicated that the most influential factor on ICER was the incidence of disease. The probability of sequelae, the cost of the vaccine and vaccine effectiveness also had an impact. Our results suggest that vaccinating infants in Italy with Bexsero® has the ability to significantly reduce meningococcal disease and, if the probable underestimation of disease incidence is considered, routine vaccination is advisable.
Identifying and Intervening in Child Maltreatment and Implementing Related National Guidelines by Public Health Nurses in Finland and Japan

Aim. This study aimed to investigate how public health nurses identify, intervene in, and implement the guidelines on child maltreatment in Finland and Japan and to compare the data between the two countries. Method. This study employed a cross-sectional design. Public health nurses' knowledge and skills with respect to child maltreatment prevention were assessed using a questionnaire consisting of three categories: identification, intervention, and implementation of guidelines. Public health nurses working in the area of maternal and child health care in Finland (n = 193) and Japan (n = 440) were the participants. Results. A significantly higher percentage of Japanese public health nurses identified child maltreatment compared to Finnish public health nurses, while Finnish nurses intervened in child maltreatment better than their Japanese counterparts. In both countries, public health nurses who had read and used the guidelines dealt with child maltreatment better than those who did not. Conclusion. The results suggest that effective training on child maltreatment and the use of guidelines are important to increase public health nurses' knowledge and skills for identifying and intervening in child maltreatment.
Theoretical antecedents and positive employee work experiences of job crafting

ii ACKNOWLEDGEMENTS . iv DEDICATION . vi TABLE OF CONTENTS . vii LIST OF TABLES . ix LIST OF FIGURES . x INTRODUCTION . 1 Aims of this Study . 3 Employees’ Role in Designing Work: Job Crafting. 4 THE CURRENT STUDY . 13 Theoretical Antecedents of Job Crafting: Model 1 . 13 Outcomes of Job Crafting and Work Design Characteristics: Model 2 . 24 Exploring the Leader’s Role . 30 Summary of the Study . 31 METHOD . 32 Participants . 32 Procedure . 34 Measures. 37 RESULTS . 43 Confirmatory Factor Analyses . 43 Cleaning Data and Checking Assumptions . 47 Model 1: Theoretical Antecedents of Job Crafting . 48 Model 2: Positive Work Experiences . 50 Qualitative Data Analysis: Exploring the Leader’s Role . 51 DISCUSSION . 56 Model 1: Theoretical Antecedents . 56 Model 2: Positive Work Experiences . 63 Implications . 66 Strengths and Limitations of the Study . 68
Service quality and student/customer satisfaction in the private tertiary education sector in Singapore

Purpose This paper focuses on students’ perceptions of the quality of non-academic services received in higher education. While the important role played by expectations and perceptions in students’ evaluations of such services has been discussed in much of the service quality literature, there is insufficient work in the private tertiary educational sector (PTES). Thus, the purpose of this paper is to examine the relationships between service quality, student satisfaction, and behavioural intentions in the PTES, using Singapore as a case study. Design/methodology/approach This study adopted quantitative research to address the research questions. Primary data were collected from 324 valid responses from a survey conducted in two private tertiary educational institutes (PTEIs) in Singapore. Findings The results suggested that perceived service quality is positively correlated to satisfaction; perceived service quality and satisfaction are positively correlated to favourable behavioural intentions; and the relationships among perceived service quality and loyalty and paying more for a service are mediated by satisfaction. Originality/value This study is significant as the results provide better insights for Singaporean administrators in PTEIs, which is an under-researched area. Generally, the results will have far-reaching implications for all stakeholders in the delivery and consumption of education services in PTEIs, within and beyond Singapore.
Comprehensive proton dose algorithm using pencil beam redefinition and recursive dynamic splitting

We compute, from first principles, the absolute dose or fluence distribution per incident proton charge in a known heterogeneous terrain exposed to known proton beams. The algorithm is equally amenable to scattered or scanned beams. All objects in the terrain (including collimators) are sliced into slabs, of any convenient thickness, perpendicular to the nominal beam direction. Transport is by standard Fermi-Eyges theory. Transverse heterogeneities are handled by breaking up pencil beams (PBs) either by conventional redefinition or a new form of 2D recursive dynamic splitting: the mother PB is replaced, conserving emittance and charge, by seven daughters of equal transverse size. One has 1/4 the charge and travels in the mother's direction and six have 1/8 the charge, are arranged hexagonally and radiate from the mother's virtual point source. The longitudinal (energy-like) variable is pv (proton momentum times speed). Each material encountered is treated on its own merits, not referenced to water. Slowing down is handled by $R=a(pv)^b$ fitted to standard range-energy tables. Multiple Coulomb scattering is handled by a scattering power $T_\mathrm{dM}$ acting as a proxy for Moliere theory. We present examples from a proof-of-principle Fortran program and speculate about putting the algorithm into practice.