Miracle-dz/UniFAR-FTUs huggingface dataset:
Sparse Spikes Deconvolution on Thin Grids

This article analyzes the recovery performance of two popular finite dimensional approximations of the sparse spikes deconvolution problem over Radon measures. We examine in a unified framework both the L1 regularization (often referred to as Lasso or Basis-Pursuit) and the Continuous Basis-Pursuit (C-BP) methods. The Lasso is the de-facto standard for the sparse regularization of inverse problems in imaging. It performs a nearest neighbor interpolation of the spikes locations on the sampling grid. The C-BP method, introduced by Ekanadham, Tranchina and Simoncelli, uses a linear interpolation of the locations to perform a better approximation of the infinite-dimensional optimization problem, for positive measures. We show that, in the small noise regime, both methods estimate twice the number of spikes as the number of original spikes. Indeed, we show that they both detect two neighboring spikes around the locations of an original spikes. These results for deconvolution problems are based on an abstract analysis of the so-called extended support of the solutions of L1-type problems (including as special cases the Lasso and C-BP for deconvolution), which are of an independent interest. They precisely characterize the support of the solutions when the noise is small and the regularization parameter is selected accordingly. We illustrate these findings to analyze for the first time the support instability of compressed sensing recovery when the number of measurements is below the critical limit (well documented in the literature) where the support is provably stable.
A Theory of the Interhemispheric Meridional Overturning Circulation and Associated Stratification

AbstractA quantitative theoretical model of the meridional overturning circulation and associated deep stratification in an interhemispheric, single-basin ocean with a circumpolar channel is presented. The theory includes the effects of wind, eddies, and diapycnal mixing and predicts the deep stratification and overturning streamfunction in terms of the surface forcing and other parameters of the problem. It relies on a matching among three regions: the circumpolar channel at high southern latitudes, a region of isopycnal outcrop at high northern latitudes, and the ocean basin between.The theory describes both the middepth and abyssal cells of a circulation representing North Atlantic Deep Water and Antarctic Bottom Water. It suggests that, although the strength of the middepth overturning cell is primarily set by the wind stress in the circumpolar channel, middepth stratification results from a balance between the wind-driven upwelling in the channel and deep-water formation at high northern latitudes. D.
Key-frame extraction algorithm using entropy difference

The fast evolution of the digital video technology has opened new areas of research. The most important aspect will be to develop algorithms to perform video cataloguing, indexing and retrieval. The basic step is to find a way for video abstraction, as this will help us more for browsing a large set of video data with sufficient content representation. In this paper we present an overview of the current key-frame extraction algorithms. We propose the Entropy-Difference, an algorithm that performs spatial frame segmentation. We present evaluation of the algorithm on several video clips. Quantitative results show that the algorithm is successful in helping annotators automatically identify video key-frames
Relation of DNA Methylation of 5′-CpG Island of ACSL3 to Transplacental Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Childhood Asthma

In a longitudinal cohort of ∼700 children in New York City, the prevalence of asthma (>25%) is among the highest in the US. This high risk may in part be caused by transplacental exposure to traffic-related polycyclic aromatic hydrocarbons (PAHs) but biomarkers informative of PAH-asthma relationships is lacking. We here hypothesized that epigenetic marks associated with transplacental PAH exposure and/or childhood asthma risk could be identified in fetal tissues. Mothers completed personal prenatal air monitoring for PAH exposure determination. Methylation sensitive restriction fingerprinting was used to analyze umbilical cord white blood cell (UCWBC) DNA of 20 cohort children. Over 30 DNA sequences were identified whose methylation status was dependent on the level of maternal PAH exposure. Six sequences were found to be homologous to known genes having one or more 5′-CpG island(s) (5′-CGI). Of these, acyl-CoA synthetase long-chain family member 3 (ACSL3) exhibited the highest concordance between the extent of methylation of its 5′-CGI in UCWBCs and the level of gene expression in matched fetal placental tissues in the initial 20 cohort children. ACSL3 was therefore chosen for further investigation in a larger sample of 56 cohort children. Methylation of the ACSL3 5′-CGI was found to be significantly associated with maternal airborne PAH exposure exceeding 2.41 ng/m3 (OR = 13.8; p<0.001; sensitivity = 75%; specificity = 82%) and with a parental report of asthma symptoms in children prior to age 5 (OR = 3.9; p<0.05). Thus, if validated, methylated ACSL3 5′CGI in UCWBC DNA may be a surrogate endpoint for transplacental PAH exposure and/or a potential biomarker for environmentally-related asthma. This exploratory report provides a new blueprint for the discovery of epigenetic biomarkers relevant to other exposure assessments and/or investigations of exposure-disease relationships in birth cohorts. The results support the emerging theory of early origins of later life disease development.
Comparison of EGF with VEGF Non-Viral Gene Therapy for Cutaneous Wound Healing of Streptozotocin Diabetic Mice

Background To accelerate the healing of diabetic wounds, various kinds of growth factors have been employed. It is the short half-life of administered growth factors in hostile wound beds that have limited wide-spread clinical usage. To overcome this limitation, growth factor gene therapy could be an attractive alternative rather than direct application of factors onto the wound beds. We administered two growth factor DNAs, epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) into a cutaneous wound on diabetic mice. We compared the different characteristics of the healing wounds. Methods Streptozotocin was injected intraperitoneally to induce diabetes into C57BL/6J mice. The ultrasound micro-bubble destruction method with SonoVue as a bubbling agent was used for non-viral gene delivery of EGF828 and VEGF165 DNAs. Each gene was modified for increasing efficacy as FRM-EGF828 or minicircle VEGF165. The degree of neoangiogenesis was assessed using qualitative laser Doppler flowmetry. We compared wound size and histological findings of the skin wounds in each group. Results In both groups, accelerated wound closure was observed in the mice receiving gene therapy compared with non treated diabetic control mice. Blood flow detected by laser doppler flowmetry was better in the VEGF group than in the EGF group. Wound healing rates and histological findings were more accelerated in the EGF gene therapy group than the VEGF group, but were not statistically significant. Conclusion Both non-viral EGF and VEGF gene therapy administrations could improve the speed and quality of skin wound healing. However, the detailed histological characteristics of the healing wounds were different.
The significance of markers in the diagnosis of endometrial cancer

Endometrial cancer is one of the most common cancers experienced by women throughout the world. It is also the most common malignancy within the female reproductive system, representing 37.7% of all disorders. The incidence increases with age, and is diagnosed most frequently in women between 45 and 65 years old. In the last few years, numerous studies have been performed to identify tumour biomarkers. Biomarkers include not only protein routinely used as tumour markers but also genes and chromosomes. The limiting factor in the use of markers in the diagnosis of endometrial cancer is their lack of specificity. However, specific markers for endometrial cancer are the subject of much research attention. Although moderately elevated levels of markers are present in a number of inflammatory or non-malignant diseases, significantly increased levels of markers indicate the development of cancer. Recently, research has been focused on the identification of molecular changes leading to different histological subtypes of endometrial cancer. In this paper the authors reviewed several currently investigated markers. Progress in these investigations is very important in the diagnostics and treatment of endometrial cancer. In particular, the identification of novel mutations and molecular profiles should enhance our ability to personalise adjuvant treatment with genome-guided targeted therapy.
Effects of Tributyrin on Intestinal Energy Status, Antioxidative Capacity and Immune Response to Lipopolysaccharide Challenge in Broilers

This study was carried out to investigate the effects of tributyrin (TB) on the growth performance, pro-inflammatory cytokines, intestinal morphology, energy status, disaccharidase activity, and antioxidative capacity of broilers challenged with lipopolysaccharide (LPS). A total of 160 one-day-old Cobb broilers were allocated to 1 of 4 treatments, with 4 replicated pens per treatment and 10 birds per pen. The experiment consisted of a 2×2 factorial arrangements of treatments with TB supplementation (0 or 500 mg/kg) and LPS challenge (0 or 500 μg/kg body weight [BW]). On days 22, 24, and 26 of the trial, broilers received an intraperitoneal administration of 500 μg/kg BW LPS or saline. Dietary TB showed no effect on growth performance. However, LPS challenge decreased the average daily gain of broilers from day 22 to day 26 of the trial. Dietary TB supplementation inhibited the increase of interleukin-1β (in the jejunum and ileum), interleukin-6 (in the duodenum and jejunum), and prostaglandin E2 (in the duodenum) of LPS-challenged broilers. Similar inhibitory effects of TB in the activities of total nitric oxide synthase (in the ileum) and inducible nitric oxide synthase (in the jejunum) were also observed in birds challenged with LPS. Additionally, TB supplementation mitigated the decrease of ileal adenosine triphosphate, adenosine diphosphate and total adenine nucleotide and the reduction of jejunal catalase activity induced by LPS. Taken together, these results suggest that the TB supplementation was able to reduce the release of pro-inflammatory cytokines and improve the energy status and anti-oxidative capacity in the small intestine of LPS-challenged broilers.
Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers

Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent painless area, the disease is usually therefore diagnosed at the advanced stages; hence early detection of NPC is difficult. Furthermore, understanding in molecular pathogenesis is still lacking, pondering the identification of effective prognostic and diagnostic biomarkers. Dysregulation of signaling molecules in intracellular signal transduction, which regulate cell proliferation, apoptosis, and adhesion, underlines the basis of NPC pathogenesis. In this paper, the molecular signaling pathways in the NPC are discussed for the holistic view of NPC development and progression. The important insights toward NPC pathogenesis may offer strategies for identification of novel biomarkers for diagnosis and prognosis.
Reliance on God’s Help in Patients with Depressive and Addictive Disorders is not Associated with Their Depressive Symptoms

Objective: Although there are several reports which support a (negative) association between depression and spirituality/religiosity, the specific nature of the relationships remains unclear. To address whether patients with depressive and/or addictive disorders use this resource at all, we focused on a circumscribed variable of intrinsic religiosity, and analyzed putative associations between intrinsic religiosity, depression, life satisfaction and internal adaptive coping strategies. Methods: We referred to data of 111 patients with either depressive and/or addictive disorders treated in three German clinics. For this anonym cross sectional study, standardized instruments were used, i.e., the 5-item scale Reliance on God’s Help (RGH), Beck’s Depression Inventory (BDI), the 3-item scale Escape from Illness, the Brief Multidimensional Life Satisfaction Scale (BMLSS), and internal adaptive coping strategies as measured with the AKU questionnaire. Results: Patients with addictive disorders had significantly higher RGH than patients with depressive disorders (F = 3.6; p = 0.03). Correlation analyses revealed that RGH was not significantly associated with the BDI scores, instead depressive symptoms were significantly associated with life satisfaction and internal adaptive coping strategies (i.e., Reappraisal: Illness as Chance and Conscious Living). Patients with either low or high RGH did not significantly differ with respect to their BDI scores. None of the underlying dimensions of RGH were associated with depression scores, but with life satisfaction and (negatively) with Escape from illness. Nevertheless, patients with high RGH had significantly higher adaptive coping strategies. Regression analyses revealed that Reappraisal as a cognitive coping strategy to re-define the value of illness and to use it as a chance of development (i.e., change attitudes and behavior), was the best predictor of patients’ RGH (Beta = 0.36, p = 0.001), while neither depression as underlying disease (as compared to addictive disorders) nor patients’ life satisfaction had a significant influence on their RGH. Conclusions: Although RGH was significantly higher in patients with addictive disorders than in patients with depressive disorders, depressive symptoms are not significantly associated with patients’ intrinsic religiosity. Particularly those patients with high intrinsic religiosity seem to have stronger access to positive (internal) strategies to cope, and higher life satisfaction. Whether spirituality/religiosity is used by the patients as a reliable resource may depend on their individual experience during live, their expectations, and specific world-view.
Benefits of centralized digital information management in multipartner projects

Centralized digital information management is used to support project management, management and distribution of project information, and to promote cooperation in the building process. Today, a common interface to centralized information storage is an Internet-based, project team collaboration application developed for document and project management and provided by application service providers (ASPs). Commercial applications have been taken into use at a remarkable volume and in recent years the construction industry has recognized the need for assessment of benefits of them as well as benefits of ICT in more general. This paper presents results of VTTs ProCE research (Project Management and Organization in the Concurrent Engineering Environment) carried out 2000-2002. One objective of the Finnish-American research project was to measure the impact of different Concurrent Engineering (CE) environment features in multi-partner projects, showing the available benefits. A framework for measuring the benefit of using the CE-environment was created to evaluate benefits in case study projects. With respect to related research carried out earlier, a specific development is the qualitative benefit measurement. The model was developed and tested mainly in the first analyzed case study, which, in August 2000, was completed and handed over to the client in Finland. Additionally, the framework was used in three other case studies, in Sweden, Great Britain, and the USA. A fundamental conclusion of the study is that by using digital information exchange and a modern CE environment, significant qualitative benefits can be reached in a multi-partner project. The CE environment makes it possible to change the traditional information flow, thereby radically improving it at the design and construction stages. In addition to qualitative benefits, benefits measured in terms of time and money can be reached. However, the study showed that indirect cost savings are difficult to quantitatively measure in practice.
Obstructive Sleep Apnea Patients Having Surgery Are Less Associated with Glaucoma

Objective. To investigate if different treatment strategy of obstructive sleep apnea (OSA) was associated glaucoma risk in Taiwanese population. Methods. Population-based retrospective cohort study was conducted using data sourced from the Longitudinal Health Insurance Database 2000. We included 2528 OSA patients and randomly selected and matched 10112 subjects without OSA as the control cohort. The risk of glaucoma in OSA patients was investigated based on the managements of OSA (without treatment, with surgery, with continuous positive airway pressure (CPAP) treatment, and with multiple modalities). The multivariable Cox regression was used to estimate hazard ratio (HR) after adjusting for sex, age, hypertension, diabetes, hyperlipidemia, and coronary artery disease. Results. The adjusted HR of glaucoma for OSA patients was 1.88 (95% CI: 1.46–2.42), compared with controls. For patients without treatment, the adjusted HR was 2.15 (95% CI: 1.60–2.88). For patients with treatments, the adjusted HRs of glaucoma were not significantly different from controls, except for those with CPAP (adjusted HR = 1.65, 95% CI = 1.09–2.49). Conclusions. OSA is associated with an increased risk of glaucoma. However, surgery reduces slightly the glaucoma hazard for OSA patients.
On the Rotational Dynamics of Magnetically Threaded Disks around Neutron Stars

We investigate the rotational dynamics of disk accretion around a strongly magnetized neutron star with an aligned dipole field. The magnetospheric field is assumed to thread the disk plasma both inside and outside the corotation radius. As a result of disk-star interaction, the magnetic torque on the disk affects the structure of accretion flow to yield the observed spin-up or spin-down rates for a source of given fastness, magnetic field strength, and mass accretion rate. Within the model we obtain a prescription for the dynamical viscosity of such magnetically modified solutions for a Keplerian disk. We then use this prescription to find a model solution for the rotation rate profile throughout the entire disk, including the non-Keplerian inner disk. We find that the non-Keplerian angular velocity transition region is not necessarily narrow for a source of given spin state. The boundary layer approximation, as in the standard magnetically threaded disk model, holds only in the case of dynamical viscosity decreasing all the way to the innermost edge of the disk. These results are applied to several observed disk-fed X-ray pulsars that have exhibited quasi-periodic oscillations (QPOs). The QPO frequencies provide a constraint on the fastness parameter and enable one to determine uniquely the width of the angular velocity transition zone for each source within model assumptions. We discuss the implications of these results on the value of the critical fastness parameter for a magnetized star in spin equilibrium. Applications of our model are also made with relevant parameters from recent numerical simulations of quasi-stationary disk-magnetized star interactions.
Spatiotemporal Dynamics of Feature-Based Attention Spread: Evidence from Combined Electroencephalographic and Magnetoencephalographic Recordings

Attentional selection on the basis of nonspatial stimulus features induces a sensory gain enhancement by increasing the firing-rate of individual neurons tuned to the attended feature, while responses of neurons tuned to opposite feature-values are suppressed. Here we recorded event-related potentials (ERPs) and magnetic fields (ERMFs) in human observers to investigate the underlying neural correlates of feature-based attention at the population level. During the task subjects attended to a moving transparent surface presented in the left visual field, while task-irrelevant probe stimuli executing brief movements into varying directions were presented in the opposite visual field. ERP and ERMF amplitudes elicited by the unattended task-irrelevant probes were modulated as a function of the similarity between their movement direction and the task-relevant movement direction in the attended visual field. These activity modulations reflecting globally enhanced processing of the attended feature were observed to start not before 200 ms poststimulus and were localized to the motion-sensitive area hMT. The current results indicate that feature-based attention operates in a global manner but needs time to spread and provide strong support for the feature-similarity gain model.
Combining Text Mining and Data Mining for Bug Report Classification

Misclassification of bug reports inevitably sacrifices the performance of bug prediction models. Manual examinations can help reduce the noise but bring a heavy burden for developers instead. In this paper, we propose a hybrid approach by combining both text mining and data mining techniques of bug report data to automate the prediction process. The first stage leverages text mining techniques to analyze the summary parts of bug reports and classifies them into three levels of probability. The extracted features and some other structured features of bug reports are then fed into the machine learner in the second stage. Data grafting techniques are employed to bridge the two stages. Comparative experiments with previous studies on the same data -- three large-scale open source projects -- consistently achieve a reasonable enhancement (from 77.4% to 81.7%, 73.9% to 80.2% and 87.4% to 93.7%, respectively) over their best results in terms of overall performance. Additional comparative empirical experiments on other two popular open source repositories confirm the findings and demonstrate the benefits of our approach.
Drug adherence behavior among hypertensive out-patients at a tertiary health institution in Manicaland province, Zimbabwe, 2011

Objectives This study investigated the level of drug adherence among hypertensive outpatients at a tertiary hospital in Zimbabwe. Specific objectives included measurement of blood pressure (BP) control achievement, estimating prevalence of drug adherence behavior, and establishing the association between drug adherence behavior and achievement of BP control. Methods and materials An analytic cross sectional design was applied on a convenience sample of 102 participants using an interviewer administered questionnaire. Self-reported adherence was assessed using the Morisky Medication Adherence Scale. Findings The median age of participants was 68.5 years (Q1 61;Q3 76). The majority were female (n = 71;69.6%). BP control (< 140/90 mmHg) was achieved in 52% (n = 53). Self-reported drug adherence was 40.2% (n = 42). After multivariate logistic regression analysis, participants with normal BP measurements were more than three times as likely to report maximal adherence to prescribed drug schedules (odds ratio 3.37; 95% confidence interval: 1.38–.24). Conclusion Poor drug adherence behavior prevails among hypertensive outpatients. This contributes to poor achievement of BP control. The hospital is recommended to set up a specialized hypertension clinic in the Out-patients’ Department where an intensified health education package can be introduced as well as community awareness programs on the importance of medication adherence.