Miracle-dz/UniFAR-FTUs huggingface dataset:
Sequential degradation of heparan sulfate in the subendothelial extracellular matrix by highly metastatic lymphoma cells

A highly metastatic variant (ESb) of a methylchol‐anthrene‐induced T lymphoma elaborates a heparan sulfate (HS) degrading endoglycosidase (heparanase) to a much higher extent than its non‐metastatic parental subline (Eb). Whereas a serum‐free medium conditioned by either subline contained a trypsin‐like serine protease, heparanase activity was detected only in the ESb‐conditioned medium (CM). ESb CM was incubated with a naturally produced, sulfate‐labelled subendothelial extracellular matrix (ECM) or with a soluble, high‐MW labelled proteoglycan first released from the ECM by incubation with Eb CM or with the partially purified ESb protease. Sulfate labelled degradation products were analyzed by gel filtration on Sephrose 6B. The optimal pH for degradation of ECM‐bound HS was 6.2 as compared to pH 5.2 for degradation of the soluble proteoglycan. Heparanase‐me‐diated degradation of both ECM‐bound and soluble HS was inhibited by heparin. Addition of either tryp‐sin, plasmin or to a lower extent, the purified ESb protease, stimulated between 5‐ and 20‐fold the ESb CM‐mediated degradation of ECM‐bound HS but had no effect on heparanase‐mediated degradation of the soluble proteoglycan. This stimulation was inhibited in the presence of heparin or protease inhibitors. These results indicate that both a protease and heparanase are involved in the ESb‐mediated degradation of ECM‐bound HS and that one enzyme produces a more accessible substrate for the next enzyme. This sequential cleavage is characteristic of degradation of a multimolecular structure such as the subendothelial ECM and hence cannot be detected in studies with its isolated constituents.
Prismatic Adaptation Induces Plastic Changes onto Spatial and Temporal Domains in Near and Far Space

A large literature has documented interactions between space and time suggesting that the two experiential domains may share a common format in a generalized magnitude system (ATOM theory). To further explore this hypothesis, here we measured the extent to which time and space are sensitive to the same sensorimotor plasticity processes, as induced by classical prismatic adaptation procedures (PA). We also exanimated whether spatial-attention shifts on time and space processing, produced through PA, extend to stimuli presented beyond the immediate near space. Results indicated that PA affected both temporal and spatial representations not only in the near space (i.e., the region within which the adaptation occurred), but also in the far space. In addition, both rightward and leftward PA directions caused opposite and symmetrical modulations on time processing, whereas only leftward PA biased space processing rightward. We discuss these findings within the ATOM framework and models that account for PA effects on space and time processing. We propose that the differential and asymmetrical effects following PA may suggest that temporal and spatial representations are not perfectly aligned.
Moderate Depression Promotes Posttraumatic Growth (Ptg): A Young Population Survey 2 Years after the 2009 L’Aquila Earthquake

Background: Earthquakes can result in a range of psychopathology and in negative and positive consequences for survivors. Objective: To examine the association between clinical aftereffects (anxiety and depressive symptoms) and post-traumatic growth (PTG) among young survivors of the 2009 L’Aquila earthquake, Italy. Method: 316 young earthquake survivors enrolled in the University of L’Aquila were evaluated two years after the natural disaster. Participants completed three main questionnaires, including Patient Health Questionnaire-9 items (PHQ-9), Self-Rating Anxiety Scale (SAS), and Posttraumatic Growth Inventory (PTGI). Results: 59.6% of the student sample showed different levels of depression, whereas 13.3% reported anxiety symptoms. In both clinical dimensions (anxiety and depression), gender differences were found: female gender was confirmed risk factor for a clinical post-traumatic response. Personal PTG, demonstrated by 18% of the L’Aquila youths included in our sample, was predicted by moderate levels of depression (O.R. 2.7). In our model, gender, age, and anxiety did not show any predictive value. Conclusion: In a post-traumatic setting, the development of individual cognitive strategies is crucial, whereas after a natural disaster, paradoxically, a moderate depressive condition and the related distress could promote the drive to overcome the psychological consequences of the traumatic event.
The Actor, Partner, Similarity Effects of Personality, and Interactions with Gender and Relationship Duration among Chinese Emerging Adults

Understanding personality effects and their role in influencing relationship quality, varied according to gender and relationship duration, could help us better understand close relationships. Participants were Chinese dating dyads and were asked to complete both the Big Five Inventory and Perceived Relationship Quality Component scales. Males and those who had a long-term relationship perceived better relationship quality; individuals who scored higher on agreeableness, conscientiousness, openness, and emotional stability enjoyed better relationship quality; gender and/or relationship duration moderated the actor effect of extraversion and the partner effects of conscientiousness, emotional stability, and openness on relationship quality. Regarding the profile similarity, those couples who were more dissimilar in their profile personality had better relationship quality, especially when they were in a relatively long-term relationship. Meanwhile, with an increase in profile similarity, the males' perceived relationship quality decreased.
Novel Caprine Adeno-Associated Virus (AAV) Capsid (AAV-Go.1) Is Closely Related to the Primate AAV-5 and Has Unique Tropism and Neutralization Properties

ABSTRACT Preexisting humoral immunity to adeno-associated virus (AAV) vectors may limit their clinical utility in gene delivery. We describe a novel caprine AAV (AAV-Go.1) capsid with unique biological properties. AAV-Go.1 capsid was cloned from goat-derived adenovirus preparations. Surprisingly, AAV-Go.1 capsid was 94% identical to the human AAV-5, with differences predicted to be largely on the surface and on or under the spike-like protrusions. In an in vitro neutralization assay using human immunoglobulin G (IgG) (intravenous immune globulin [IVIG]), AAV-Go.1 had higher resistance than AAV-5 (100-fold) and resistance similar to that of AAV-4 or AAV-8. In an in vivo model, SCID mice were pretreated with IVIG to generate normal human IgG plasma levels prior to the administration of AAV human factor IX vectors. Protein expression after intramuscular administration of AAV-Go.1 was unaffected in IVIG-pretreated mice, while it was reduced 5- and 10-fold after administration of AAV-1 and AAV-8, respectively. In contrast, protein expression after intravenous administration of AAV-Go.1 was reduced 7.1-fold, similar to the 3.8-fold reduction observed after AAV-8administration in IVIG-pretreated mice, and protein expression was essentially extinguished after AAV-2 administration in mice pretreated with much less IVIG (15-fold). AAV-Go.1 vectors also demonstrated a marked tropism for lung when administered intravenously in SCID mice. The pulmonary tropism and high neutralization resistance to human preexisting antibodies suggest novel therapeutic uses for AAV-Go.1 vectors, including targeting diseases such as cystic fibrosis. Nonprimate sources of AAVs may be useful to identify additional capsids with distinct tropisms and high resistance to neutralization by human preexisting antibodies.
Modeling the reminiscence bump in autobiographical memory with the Memory Chain Model

In this article, we researched the distribution of the autobiographical memory by using the Galton -Crovitz cueing method. We obtained random memory samples of 1 587 subjects between 10 and 70 years through the Internet. We checked for telescoping, but we found no overall effect for temporal displacement. We did find more evidence for a ‘reminiscence bump’ between 10 and 30 years, which can be explained by differen tiating the memory distribution into two separate functions, namely a decline function and an encoding-sampling function. Our new Memory Chain Model, which can incorporate both functions, was used to fit the empirical distributions and gave good fits.
O consumo de souvenirs e a experiência turística em Curitiba (PR)

The souvenirs are objects present constantly in tourist destinations, available to visitors, often greedy by consumption of this product type. Despite being little explored in scientific research and considered something of low value for some researchers, the souvenir has some biases to be explored, especially to what concerns the relation of the same with the ‘tangibilization’ of the tourist experience. To this end, after the literature search, carried out a field survey with the application of questionnaires to 50 visitors in three of the main tourist attractions in Curitiba, considering as criteria for choosing the fact that the souvenirs are being sold in this attractions. As main result, has been that the shopping experience can be considered significant during the trips, especially when it comes to buying souvenirs of visited places. So, it is identified that the souvenirs’ consumptions affects directly the tourist experiences in Curitiba.
Social Attitudes toward Men and Women with Posttraumatic Stress Disorder

Although men are more likely to experience traumatic events, the risk of developing Posttraumatic Stress Disorder is at least twice as high in women than in men after exposure to comparable traumas. These findings are more consistent in response to some types of trauma (e.g., assaultive violence) than others (e.g., natural disaster). There has been very little systematic study of the sources of these gender differences. This study began to explore the contribution of gender-related beliefs about appropriate responses to trauma by investigating the impact of victim sex and trauma type as well as participant sex, sex-role orientation, and personal trauma history on attitudes towards victims. Ninety-three male and 179 female students were administered the Bem Sex Role Inventory, the Trauma History Questionnaire, and a vignette measure of attitudes towards victims. Participants evaluated male victims significantly less favorably than female victims, and females had more positive attitudes towards victims than males. Feminine sex-typed and androgynous women rated victims more favorably than masculine sex-typed men and women. The interaction between sex of victim and trauma type was not significant. A positive relation was observed between personal trauma exposure and attitudes towards male victims among male participants only. These findings contribute towards a theoretical understanding of gender and PTSD, and also have important clinical applications.
Genetically optimized fuzzy polynomial neural networks

In this paper, we introduce a new topology of fuzzy polynomial neural networks (FPNNs) that is based on a genetically optimized multilayer perceptron with fuzzy polynomial neurons (FPNs). The study offers a comprehensive design methodology involving mechanisms of genetic optimization, especially those exploiting genetic algorithms (GAs). Let us recall that the design of the "conventional" FPNNs uses an extended group method of data handling (GMDH) and uses a fixed scheme of fuzzy inference (such as simplified, linear, and regression polynomial fuzzy inference) in each FPN of the network. It also considers a fixed number of input nodes (as being selected in advance by a network designer) at FPNs (or nodes) located in each layer. However such design process does not guarantee that the resulting FPNs will always result in an optimal networks architecture. Here, the development of the FPNN gives rise to a structurally optimized topology and comes with a substantial level of flexibility which becomes apparent when contrasted with the one we encounter in the conventional FPNNs. The design of each layer of the FPNN deals with its structural optimization involving a selection of preferred nodes (or FPNs) with specific local characteristics (such as the number of input variables, the order of the polynomial forming a consequent part of fuzzy rules and a collection of the specific subset of input variables) and addresses detailed aspects of parametric optimization. Along this line, two general optimization mechanisms are explored. The structural optimization is realized via GAs. In case of the parametric optimization we proceed with a standard least square method-based learning. Through the consecutive process of such structural and parametric optimization, an optimized and flexible fuzzy neural network becomes generated in a dynamic fashion. To evaluate the performance of the genetically optimized FPNN (gFPNN), we experimented with two time series data (gas furnace and chaotic time series) as well as some synthetic data. A comparative analysis reveals that the proposed FPNN exhibits higher accuracy and superb predictive capability in comparison to some previous models available in the literature.
Direct Thermoelectric Hydrocarbon Gas Sensors Based on  ${\rm SnO}_{2}$

Direct thermoelectric gas sensors offer a promising measurement principle. Similar to the conductivity, the measurand Seebeck coefficient depends on the ambient gas atmosphere. Moreover, and unlike the conductivity, it is independent from the geometry of the gas sensitive film. This behavior is clearly demonstrated in a comparison of a fresh sensor and a sensor that was deliberately milled out. As an exemplary material for a gas sensitive film, tin dioxide was chosen. Direct thermoelectric gas sensors, therefore, promise better long-term stability, since in contrast to conductometric sensors aging phenomena-like cracks and abrasions do not affect the Seebeck coefficient. Thermoelectric gas sensors are difficult to measure, not only because a voltage and a temperature difference have to be measured, but also with respect to problems that occur, if one measures small thermovoltages on high-ohmic films. Hence, we optimized the design of the direct thermoelectric gas-sensing device, with special respect to low internal film resistances. The result of this optimization is a thermoelectric gas sensor with an accuracy comparable to conductometric gas sensors.
Virtuous or Vitriolic

In an effort to encourage community dialogue while also building reader loyalty, online newspapers have offered a way for readers to become engaged in the news process, most popularly with online reader comment boards. It is here that readers post their opinion following an online news story, and however much community interaction taking place therein, one thing appears evident: sometimes the comments are civil; sometimes they are not. Indeed, one of the chief defining characteristics of these boards has become the rampant incivility—a dilemma many newspapers have struggled with as they seek to strengthen the value of the online dialogue. Many journalists and industry observers have pointed to a seemingly straightforward reason for the offensive comments: anonymity. Despite the claim, however, there is a striking dearth of empirical evidence in the academic literature of the effect that anonymity has on commenters' behavior. This research offers an examination of user comments of newspapers that allow anonymity (N=450) and the user comments of newspapers that do not (N=450) and compares the level of civility in both. In each group, comments follow news stories on immigration, a topic prevalent in the news in recent years and which is especially controversial and prone to debate. Results of this quantitative content analysis, useful for journalism practitioners and scholars, provide empirical evidence of the effect that anonymity has on the civility of user comments.
Mobile agents for network management

In this article we discuss the potential uses of mobile agents in network management and define software agents and a navigation model that determines agent mobility. We list a number of potential advantages and disadvantages of mobile agents and include a short commentary on the ongoing standardization activity. The core of this article comprises descriptions of several actual and potential applications of mobile agents in the five OSI functional areas of network management. A brief review of other research activity in the area and prospects for the future conclude the presentation.
The M. tuberculosis antigen 85 complex and mycolyltransferase activity

Aims: The antigen 85 complex (Ag85) from Mycobacterium tuberculosis consists of three abundantly secreted proteins (FbpA, FbpB and FbpC2) which play a key role in the pathogenesis of tuberculosis and also exhibit cell wall mycolyltransferase activity. A related protein with similarity to the Ag85 complex was recently annotated in the M. tuberculosis genome as FbpC1. An investigation was carried out to determine whether FbpC1 may also possess mycolyltransferase activity, a characteristic feature of the Ag85 complex.
The Impact of Relational Maintenance Behaviors on Marital Satisfaction: A Longitudinal Analysis

In this study we investigate the longitudinal relation between maintenance behaviors and marital satisfaction. Forty married couples completed measures of maintenance behaviors and marital satisfaction at Time 1. The couples again completed the measure of marital satisfaction 1 year later. Analyses revealed that the use of maintenance behaviors at Time 1 was related to perceptions of satisfaction at Time 2. Further, certain maintenance behaviors seem to be more influential than others in predicting later perceptions of marital satisfaction. The findings suggest that the maintenance behaviors of wives and husbands are systemically and dynamically connected, and that the maintenance of marriages is a highly complex process.
Are Moderators of the Customer Satisfaction–Repurchase Intention Relationship Contingent on the Service Category? An Exploratory Investigation

This study posits that the presence of variables that moderate the relationship between customer satisfaction and repurchase intention is contingent on the service category. Two broad service categories are evaluated: discrete services offering experiential benefits and continuous services offering functional benefits. Switching costs and variety seeking are investigated as moderators. The data for empirically addressing the research hypotheses were collected from over 180 customers. The findings suggest that moderators are contingent on the service category. Switching costs was significant for continuous services with functional benefits, whereas variety seeking was significant for discrete services with experiential benefits.
Vocational Qualifications and Higher Education: Some Policy Issues

This article reviews the reactions to higher-level National Vocational Qualifications (NVQs) in the United Kingdom in the context of certification levels by level and subject. The most successful higher NVQs are linked to professional qualifying routes, have generic application across a range of sectors or fill gaps where qualifications were not previously established. Research among the main stakeholders to gauge their attitudes towards higher NVQs shows that, among positive aspects, some adverse attitudes still exist surrounding issues of comparability, the assessment experience and the design of occupational standards. Suggestions for overcoming these issues are given. However, the wider picture shows that support for occupational standards is strong and it is the use of standards, which may or may not involve NVQs, that will help to drive forward new policy initiatives addressing participation in the sector.
Homecoming at Atwater University

Atwater University (AU) administration is struggling with an increased number of student alcohol-related problems. In particular, during the annual homecoming parade, students are extremely intoxicated and belligerent toward alumni. The new dean of students is appalled by the condoned student behavior. He also received two complaint letters from members of the AU community. The dean of students charges his subordinates with fixing the related problems.
Highly correlated hedonic and eudaimonic well-being thwart genomic analysis

In PNAS, Frederickson and colleagues (1) claim “hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms. ” Complex analyses depend entirely on distinguishing hedonic vs. eudaimonic well-being with a self-report measure. Any interpretation needs to accommodate the high likelihood of confounding and reverse causality with genetic influences on both gene expression and well-being.
Beauty and the brain: culture, history and individual differences in aesthetic appreciation

Human aesthetic processing entails the sensation‐based evaluation of an entity with respect to concepts like beauty, harmony or well‐formedness. Aesthetic appreciation has many determinants ranging from evolutionary, anatomical or physiological constraints to influences of culture, history and individual differences. There are a vast number of dynamically configured neural networks underlying these multifaceted processes of aesthetic appreciation. In the current challenge of successfully bridging art and science, aesthetics and neuroanatomy, the neuro‐cognitive psychology of aesthetics can approach this complex topic using a framework that postulates several perspectives, which are not mutually exclusive. In this empirical approach, objective physiological data from event‐related brain potentials and functional magnetic resonance imaging are combined with subjective, individual self‐reports.
Effect of platinum combined with irinotecan or paclitaxel against large cell neuroendocrine carcinoma of the lung.

BACKGROUND The efficacy of chemotherapy in patients with large cell neuroendocrine carcinoma of the lung (LCNEC) remains unclear. METHODS Of 42 consecutive patients with LCNEC, 22 with measurable disease receiving chemotherapy were enrolled as the subjects of this study. The clinical characteristics and objective responses to chemotherapy in these patients were analysed retrospectively. RESULTS The distribution of the disease stage in the patients consisting of 21 males and one female (median age: 67 years; range: 47-78 years) was as follows: stage IIB (n = 1), stage IIIA (n = 1), stage IIIB (n = 5), stage IV (n = 8), and post-operative recurrence (n = 7). Chemotherapy consisted of cisplatin and irinotecan (n = 9), a platinum agent and paclitaxel (n = 6), paclitaxel alone (n = 1), cisplatin and vinorelbine (n = 1), cisplatin and docetaxel (n = 1), and a platinum and etoposide (n = 4). The objective response rate in the 22 patients was 59.1% (95% CI, 38.1-80.1). An objective response was obtained in five of the nine patients receiving irinotecan and five of the seven patients receiving paclitaxel. The progression-free survival, median overall survival and 1-year survival rates were 4.1 months (95% CI, 3.1-5.1), 10.3 months (95% CI, 5.8-14.8) and 43.0% (95% CI, 20.7-65.3), respectively. The median overall survival of the patients treated with irinotecan or paclitaxel was 10.3 months (95% CI, 0-21.8), and the 1-year survival rate of these patients was 47.6% (95% CI, 20.4-74.8). CONCLUSION Our results suggest that irinotecan and paclitaxel may be active against LCNEC.