Miracle-dz/UniFAR-FTUs huggingface dataset:
Impacts of industrial baseline errors in demand side management enabled enterprise control

Despite the recognized importance of demand side management (DSM) for mitigating the impact of variable energy resources and reducing the system costs, the academic and industrial literature have taken divergent approaches to DSM implementation. The prequel to this work has demonstrated that the inflation of the net load baseline forecast, used by the industrial unit commitment formulation, leads to higher and costlier day-ahead scheduling of dispatchable resources compared to the academic method. Consequently, these baseline inflation errors have to be corrected in the downstream enterprise control activities at faster time scales, increasing the control efforts and reserve requirements for the real-time market dispatch and regulation service. This paper compares the two DSM approaches and quantifies the technical impact of industrial baseline errors in subsequent layers of control using an enterprise control methodology. The adopted enterprise control simulator encompasses three interconnected layers: a resource scheduling layer composed of a security-constrained unit commitment (SCUC), a balancing layer composed of a security-constrained economic dispatch (SCED), and a regulation layer. Baseline error is absent in the social welfare model. The simulations with the industrial model are run for different baseline error levels. The baseline inflation is assumed to have the same effects in the day-ahead and real-time market. The resulting implications of baseline errors on power grid imbalances and regulating reserve requirements are tracked. It is concluded that with the same regulating service, the introduction of baseline error leads to additional system imbalance compared to the social welfare model results, and the imbalance amplifies itself as the baseline error increases. As a result, more regulating reserves are required to achieve the same satisfactory system performance with higher baseline error.
Why CRM Efforts Fail? A Study of the Impact of Data Quality and Data Integration

This paper reports the results of a study into the implementation of data-driven customer relationship management (CRM) strategies. Despite its popularity, there is still a significant failure rate of CRM projects. A combination of survey and interviews/case studies research approach was used. It is found that CRM implementers are not investing enough efforts in improving data quality and data integration processes to support their CRM applications.
Receiver Jitter Tracking Characteristics in High-Speed Source Synchronous Links

High-speed links which employ source synchronous clocking architectures have the ability to track correlated jitter between clock and data channels up to high frequencies. However, system timing margins are degraded by channel skew between clock and data signals and high-frequency loss. This paper describes how these key channel effects impact the jitter performance and influence the clocking architecture of high-speed source synchronous links. Tradeoffs in complexity and jitter tracking performance of common per-channel de-skew circuits are discussed, along with how band-pass filtering can be leveraged to provide additional jitter filtering at the receiver. Jitter tolerance analysis for a 10Gb/s system shows that a near all-pass delay-locked loop (DLL) and phase-interpolator- (PI-) based de-skew performs best under low skew conditions, while, at high skew, architectures which leverage band-pass clock filtering or a phase-locked loop (PLL) for increased jitter filtering are more suitable. De-skew based on injection-locked oscillators (ILOs) offer a reduced complexity design and competitive jitter tolerance over a wide skew range.
Transmission of Murine Cytomegalovirus in Breast Milk: a Model of Natural Infection in Neonates

ABSTRACT Vertical transmission of viruses in breast milk can expose neonates to infectious pathogens at a time when the capacity of their immune system to control infections is limited. We developed a mouse model to study the outcomes of acquisition of murine cytomegalovirus (MCMV) when neonates are breastfed by mothers with acute or latent infection. Breast milk leukocytes collected from lactating mice were examined for the presence of MCMV IE-1 mRNA by reverse transcription-PCR (RT-PCR) with Southern analysis. As determined by this criterion, breast milk leukocytes from both acute and latent mothers were positive for MCMV. This mimics the outcome seen in humans with latent cytomegalovirus infection, where reactivation of virus occurs specifically in the lactating mammary gland. Interestingly, intraperitoneal injection of breast milk collected from mothers with latent infection was sufficient to transfer MCMV to neonatal mice, demonstrating that breast milk was a source of virus. Furthermore, we found that MCMV was transmitted from infected mothers to breastfed neonates, with MCMV IE-1 mRNA or infectious virus present in multiple organs, including the brain. In fact, 1 day of nursing was sufficient to transmit MCMV from latent mothers to breastfed neonatal mice. Together, these data validate this mouse model of vertical transmission of MCMV from mothers with acute or latent MCMV infection to breastfed neonates. Its relevance to human disease should prove useful in future studies designed to elucidate the immunological and pathological ramifications of neonatal infection acquired via this natural route.
Decision Tree Pruning via Integer Programming

Department of Industrial & System EngineeringNational University of Singapore1 Engineering Drive 2, Singapore 117576AbstractDecision tree is an important tool for classiﬁcation in data mining. Many algorithmshave been proposed to induce decision trees and most of them involve two phases,a growing phase and a pruning phase. In this paper, we concentrate on the pruningproblem. We ﬁnd that with the ultimate aim of selecting the best sub-tree with theminimal error for a separate test set, the problem can be formulated as an integerprogram with a nice structure. By exploiting the special structure of this integerprogram, we propose several interesting algorithms to identify the optimal sub-tree,including the one that is essentially the same as the well-known bottom-up pruningmethod with computational complexity of O(n). A new optimality proof of theabove algorithm is provided from the perspective of mathematical programming.Key words: Data Mining, Decision Tree, Pruning, Optimization, Integer Program,Linear Program? This research is supported by Singapore-MIT Alliance.Email addresses: yi-zhang-2@uiowa.edu (Yi Zhang), isehhc@nus.edu. sg(Huang Huei-chuen). Preprint submitted to Elsevier Science 17 August 2005
REDUCING DURATION OF UNTREATED PSYCHOSIS: CARE PATHWAYS TO EARLY INTERVENTION IN PSYCHOSIS SERVICES

Background Interventions to reduce treatment delay in first-episode psychosis have met with mixed results. Systematic reviews highlight the need for greater understanding of delays within the care pathway if successful strategies are to be developed. Aims To document the care-pathway components of duration of untreated psychosis (DUP) and their link with delays in accessing specialised early intervention services (EIS). To model the likely impact on efforts to reduce DUP of targeted changes in the care pathway. Method Data for 343 individuals from the Birmingham, UK, lead site of the National EDEN cohort study were analysed. Results A third of the cohort had a DUP exceeding 6 months. The greatest contribution to DUP for the whole cohort came from delays within mental health services, followed by help-seeking delays. It was found that delay in reaching EIS was strongly correlated with longer DUP. Conclusions Community education and awareness campaigns to reduce DUP may be constrained by later delays within mental health services, especially access to EIS. Our methodology, based on analysis of care pathways, will have international application when devising strategies to reduce DUP. Declarations of interest None.
Automorphism groups and anti-pluricanonical curves

We show the existence of an anti-pluricanonical curve on every smooth projective rational surface X which has an infinite group G of automorphisms of either null entropy or of type Z . Z (semi-direct product), provided that the pair (X, G) is minimal. This was conjectured by Curtis T. McMullen (2005) and further traced back to Marat Gizatullin and Brian Harbourne (1987). We also prove (perhaps) the strongest form of the famous Tits alternative theorem.
Effect of three different irrigation solutions applied by passive ultrasonic irrigation

Objectives This study evaluated the maximum depth and percentage of irrigant penetration into dentinal tubules by passive ultrasonic irrigation (PUI). Materials and Methods Thirty extracted human teeth were instrumented and divided into three groups. According to final irrigation regimen, 5.25% sodium hypochlorite (Group A, NaOCl), 2% chlorhexidine (Group B, CHX) and saline solution (Group C, control group) were applied with Irrisafe 20 tips (Acteon) and PUI. Irrigant was mixed with 0.1% rhodamine B. Sections at 2 mm, 5 mm, and 8 mm from the apex were examined with confocal laser scanning microscopy (CLSM). The percentage and maximum depth of irrigant penetration were measured. Kruskal-Wallis test and Mann-Whitney test were performed for overall comparison between groups at each level and for pairwise comparison, respectively. Within a group, Wilcoxon test was performed among different levels. p values less than 0.05 were considered significant. Results In all groups, highest penetration depth and percentage of penetration were observed at the 8 mm level. At 2 mm level, Groups A and B had significantly greater depths and percentages in penetration than Group C (p < 0.05), but there were no significant differences between Groups A and B. At 5 mm level, penetration depths and percentage of penetration was not significantly different among the groups. Conclusions NaOCl and CHX applied by PUI showed similar depth and percentage of penetration at all evaluated levels.
Clinical Characteristics and Risk Factors for Nosocomial Candidemia in Medical Intensive Care Units: Experience in a Single Hospital in Korea for 6.6 Years

The aim of this study was to determine candidemia incidence among patients in a medical intensive-care unit (MICU) and the associated mortality rate and to identify risk factors associated with candidemia. We retrospectively performed a 1:3 matched case-control study of MICU patients with candidemia. Controls were matched for sex, age, and Acute Physiology and Chronic Health Evaluation (APACHE) II score. Candidemia incidence was 9.1 per 1,000 admissions. The most common pathogen was Candida albicans. Crude mortality was 96% among candidemia patients and 52% among controls (P<0.001). Mortality differed significantly between the groups according to Kaplan-Meier survival analysis (P=0.024). Multivariate analysis identified the following independent risk factors for candidemia: central venous catheterization (odds ratio [OR] = 3.2, 95% confidence interval [CI]=1.2-9.0), previous steroid therapy (OR=4.7, 95% CI=1.8-12.1), blood transfusion during the same admission period (OR=6.3, 95% CI=2.4-16.7), and hepatic failure upon MICU admission (OR=6.9, 95% CI=1.7-28.4). In conclusion, we identify an additional independent risk factor for candidemia, the presence of hepatic failure on MICU admission. Therefore, increased awareness of risk factors, including hepatic failure, is necessary for the management of candidemia.
Shape measures for image retrieval

One of the main goals in content based image retrieval (CBIR) is to incorporate shape into the process in a reliable manner. In order to overcome the difficulties of directly obtaining shape information (in particular avoiding region segmentation) we develop several shape measures that tackle the problem in an indirect manner, requiring only a minimal amount of segmentation. A histogram-based scheme is then used, maintaining low complexity with high efficiency and robustness. The obtained results showed that the synergy of the shape measures worked out providing an improvement over the colour histogram.
Combinatorial Recruitment of CREB, C/EBPβ and c-Jun Determines Activation of Promoters upon Keratinocyte Differentiation

Background Transcription factors CREB, C/EBPβ and Jun regulate genes involved in keratinocyte proliferation and differentiation. We questioned if specific combinations of CREB, C/EBPβ and c-Jun bound to promoters correlate with RNA polymerase II binding, mRNA transcript levels and methylation of promoters in proliferating and differentiating keratinocytes. Results Induction of mRNA and RNA polymerase II by differentiation is highest when promoters are bound by C/EBP β alone, C/EBPβ together with c-Jun, or by CREB, C/EBPβ and c-Jun, although in this case CREB binds with low affinity. In contrast, RNA polymerase II binding and mRNA levels change the least upon differentiation when promoters are bound by CREB either alone or in combination with C/EBPβ or c-Jun. Notably, promoters bound by CREB have relatively high levels of RNA polymerase II binding irrespective of differentiation. Inhibition of C/EBPβ or c-Jun preferentially represses mRNA when gene promoters are bound by corresponding transcription factors and not CREB. Methylated promoters have relatively low CREB binding and, accordingly, those which are bound by C/EBPβ are induced by differentiation irrespective of CREB. Composite “Half and Half” consensus motifs and co localizing consensus DNA binding motifs are overrepresented in promoters bound by the combination of corresponding transcription factors. Conclusion Correlational and functional data describes combinatorial mechanisms regulating the activation of promoters. Colocalization of C/EBPβ and c-Jun on promoters without strong CREB binding determines high probability of activation upon keratinocyte differentiation.
Uptake, Outcomes, and Costs of Antenatal, Well-Baby, and Prevention of Mother-to-Child Transmission of HIV Services under Routine Care Conditions in Zambia

Background Zambia adopted Option A for prevention of mother-to-child transmission of HIV (PMTCT) in 2010 and announced a move to Option B+ in 2013. We evaluated the uptake, outcomes, and costs of antenatal, well-baby, and PMTCT services under routine care conditions in Zambia after the adoption of Option A. Methods We enrolled 99 HIV-infected/HIV-exposed (index) mother/baby pairs with a first antenatal visit in April-September 2011 at four study sites and 99 HIV-uninfected/HIV-unexposed (comparison) mother/baby pairs matched on site, gestational age, and calendar month at first visit. Data on patient outcomes and resources utilized from the first antenatal visit through six months postpartum were extracted from site registers. Costs in 2011 USD were estimated from the provider’s perspective. Results Index mothers presented for antenatal care at a mean 23.6 weeks gestation; 55% were considered to have initiated triple-drug antiretroviral therapy (ART) based on information recorded in site registers. Six months postpartum, 62% of index and 30% of comparison mother/baby pairs were retained in care; 67% of index babies retained had an unknown HIV status. Comparison and index mother/baby pairs utilized fewer resources than under fully guideline-concordant care; index babies utilized more well-baby resources than comparison babies. The average cost per comparison pair retained in care six months postpartum was $52 for antenatal and well-baby services. The average cost per index pair retained was $88 for antenatal, well-baby, and PMTCT services and increased to $185 when costs of triple-drug ART services were included. Conclusions HIV-infected mothers present to care late in pregnancy and many are lost to follow up by six months postpartum. HIV-exposed babies are more likely to remain in care and receive non-HIV, well-baby care than HIV-unexposed babies. Improving retention in care, guideline concordance, and moving to Option B+ will result in increased service delivery costs in the short term.
A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients.

BACKGROUND Although low dietary intakes of antioxidant vitamins and minerals have been associated with higher risks of cancer, results of trials testing antioxidant supplementation for cancer chemoprevention have been equivocal. We assessed whether supplementation with antioxidant vitamins could reduce the incidence of second primary cancers among patients with head and neck cancer. METHODS We conducted a multicenter, double-blind, placebo-controlled, randomized chemoprevention trial among 540 patients with stage I or II head and neck cancer treated by radiation therapy between October 1, 1994, and June 6, 2000. Supplementation with alpha-tocopherol (400 IU/day) and beta-carotene (30 mg/day) or placebo began on the first day of radiation therapy and continued for 3 years after the end of radiation therapy. In the course of the trial, beta-carotene supplementation was discontinued after 156 patients had enrolled because of ethical concerns. The remaining patients received alpha-tocopherol or placebo only. Survival was evaluated by Kaplan-Meier analysis. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. RESULTS After a median follow-up of 52 months, second primary cancers and recurrences of the first tumor were diagnosed in 113 and 119 participants, respectively. The effect of supplementation on the incidence of second primary cancers varied over time. Compared with patients receiving placebo, patients receiving alpha-tocopherol supplements had a higher rate of second primary cancers during the supplementation period (HR = 2.88, 95% CI = 1.56 to 5.31) but a lower rate after supplementation was discontinued (HR = 0.41, 95% CI = 0.16 to 1.03). Similarly, the rate of having a recurrence or second primary cancer was higher during (HR = 1.86, 95% CI = 1.27 to 2.72) but lower after (HR = 0.71, 95% CI = 0.33 to 1.53) supplementation with alpha-tocopherol. The proportion of participants free of second primary cancer overall after 8 years of follow-up was similar in both arms. CONCLUSIONS alpha-Tocopherol supplementation produced unexpected adverse effects on the occurrence of second primary cancers and on cancer-free survival.
Evolutionary growth of genomes for the development and replication of multicellular organisms with indirect encoding

The genomes of biological organisms are not fixed in size. They evolved and diverged into different species acquiring new genes and thus having different lengths. In a way, biological genomes are the result of a self-assembly process where more complex phenotypes could benefit by having larger genomes in order to survive and adapt. In the artificial domain, evolutionary and developmental systems often have static size genomes, e.g. chosen beforehand by the system designer by trial and error or estimated a priori with complicated heuristics. As such, the maximum evolvable complexity is predetermined, in contrast to open-ended evolution in nature. In this paper, we argue that artificial genomes may also grow in size during evolution to produce high-dimensional solutions incrementally. We propose an evolutionary growth of genome representations for artificial cellular organisms with indirect encodings. Genomes start with a single gene and acquire new genes when necessary, thus increasing the degrees of freedom and expanding the available search-space. Cellular Automata (CA) are used as test bed for two different problems: replication and morphogenesis. The chosen CA encodings are a standard developmental table and an instruction based approach. Results show that the proposed evolutionary growth of genomes' method is able to produce compact and effective genomes, without the need of specifying the full set of regulatory configurations.
Melatonin and S-20098 increase REM sleep and wake-up propensity without modifying NREM sleep homeostasis.

The pineal hormone melatonin has been implicated in the circadian regulation of sleep. In a crossover design, we investigated the effect of acute administration of 5 mg melatonin and a melatonin agonist (S-20098, 5 and 100 mg) in healthy young men when given 5 h before bedtime on sleep structure and electroencephalogram (EEG) power density. Each trial comprised a baseline, a treatment, and a posttreatment sleep episode. Relative to the placebo condition, all treatments phase advanced the core body temperature rhythm [Kräuchi, K. , C. Cajochen, D. Möri, C. Hetsch, and A. Wirz-Justice. Sleep Res. 24: 526, 1995; and Kräuchi, K. , C. Cajochen, D. Möri, and A. Wirz-Justice. Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41): R1178-1188, 1997]. Rapid eye movement (REM) sleep was increased after both melatonin and S-20098. This increase in REM sleep was most pronounced in the first REM sleep episode. On the posttreatment night after melatonin and S-20098 administration, more wakefulness was present in the latter one-half of the sleep episode. EEG power density between 0.25 and 20 Hz during either non-REM (NREM) or REM sleep did not differ from placebo. Thus a single early evening dose of melatonin or the agonist S-20098 increases REM sleep propensity and advances sleep termination while, at the same time, the EEG in NREM sleep remains unaffected.
Current concepts and guidelines in chin graft harvesting: A literature review

After tooth loss, alveolar ridge resorption is a common phenomenon, which alters the size and shape of the host bone available for the dental implant placement. In the era of prosthetic driven implant dentistry, the final prosthesis type and design dictates the number, size and the ideal implant position. In clinical practice, though patients often demand osseointegrated implants to replace their missing teeth; the deficiency of bone volume is the primary reason for avoiding such treatment options. The solution to such situations lies in the re-establishment of the ridge height consistent with prosthetic design and with suitable load-bearing lamellar bone for implant placement and long-term stability. Despite recent advances in bone grafts and bone-substitute technology, the use of autogenous bone grafts continues to represent the gold standard in implant site reconstructive surgery. The mandibular symphysis (chin bone in interforaminal region) is a favorable donor site as it has an excellent risk-benefit ratio. Several reconstruction procedures by using chin graft have been proposed to increase alveolar bone volume both vertically and laterally to prepare the ridge for a correct placement of oral implants. This article reviews the various aspects of chin grafts, wherein the regional surgical anatomy, various incision designs, surgical protocols for harvesting and the possible clinical and esthetic complications of chin grafts have been discussed.