Miracle-dz/UniFAR-FTUs huggingface dataset:
β-Arrestin 2-Dependent Angiotensin II Type 1A Receptor-Mediated Pathway of Chemotaxis

Chemotaxis is a cellular response that directs cell migration toward a chemical gradient and is fundamental to a variety of cellular processes. The receptors for most known chemokines belong to the seven transmembrane-spanning superfamily and signal through members of the Gαi family. β-Arrestins, in addition to regulating desensitization, have emerged as potential mediators of G-protein-independent signaling pathways and have been implicated in several chemotactic pathways. Here, we report a system wherein chemotaxis is stimulated in a β-arrestin 2-dependent and apparently G-protein-independent manner. Human embryonic kidney 293 cells with stable expression of the angiotensin II (Ang II) receptor type 1A (AT1AR) undergo chemotaxis in response to Ang II. An Ang II peptide analog S1I4I8 Ang II that is unable to activate G-protein-mediated responses induces chemotaxis in these cells that is unaffected by pertussis toxin-mediated suppression of Gαi. Suppression of β-arrestin 2 expression using small interfering RNA (siRNA) essentially eliminated AT1AR-mediated chemotaxis induced by either Ang II or the S1I4I8 Ang II peptide but had no effect on epidermal growth factor (EGF)-induced chemotaxis. It also abolished chemotaxis induced by lysophosphatidic acid (LPA), which was completely sensitive to pertussis toxin. In contrast, reduction of Gαq/11 through siRNA and inhibition of protein kinase C, extracellular signal-regulated kinases 1 and 2, or phosphatidylinositol-3-kinase did not diminish AT1AR-mediated chemotaxis. Inhibiting p38 mitogen-activated protein kinase decreased AT1AR-mediated chemotaxis and eliminated EGF-mediated chemotaxis, suggesting that p38 plays a role in chemotaxis that is not specific to the AT1AR in this system. These data suggest that β-arrestin 2 can mediate chemotaxis through mechanisms which may be G-protein-independent (Ang II receptors) or -dependent (LPA receptors).
The problems with eclipse modeling tools: a topic analysis of eclipse forums

Eclipse offers a wide range of tools supporting various aspects of modeling and Model-Driven Engineering (MDE). Arguably, the Eclipse ecosystem has been and continues to be one of the most important modeling tool repositories and sources of information about these tools, with, for example, more than 180,000 posts in the modeling forums since 2002. In this paper, we collect and analyze the content of the 30 most widely used Eclipse forums associated with different modeling and MDE tools, such as EMF, Xtext, ATL, Epsilon, and GMF. Using state-of-the-art text mining techniques coupled with manual analysis, we explore these forums with respect to two important questions: What are the primary issues, problems, and challenges raised in the use of these tools? And, perhaps even more important: Which of these issues are most commonly faced by "newbies" in the MDE community? Our study provides supporting evidence for some commonly held but unproven beliefs, such that plug-ins and documentation issues are the most common, and suggests which issues actually present the biggest "barriers to entry" for new users of MDE tools, and how they might be addressed.
MODERATE DEVIATIONS FOR STATIONARY PROCESSES

We obtain asymptotic expansions for probabilities of moderate deviations for stationary causal processes. The imposed dependence conditions are easily verifiable and they are directly related to the data-generating mechanism of the underlying processes. The results are applied to functionals of linear processes and nonlinear time series. We carry out a simulation study and investigate the relationship between accuracy of tail probabilities and the strength of dependence.
Inactivation of excitation-contraction coupling in rat extensor digitorum longus and soleus muscles

K contractures and two-microelectrode voltage-clamp techniques were used to measure inactivation of excitation-contraction coupling in small bundles of fibers from rat extensor digitorum longus (e.d.l.) and soleus muscles at 21 degrees C. The rate of spontaneous relaxation was faster in e.d. l. fibers: the time for 120 mM K contractures to decay to 50% of maximum tension was 9.8 +/- 0.5 s (mean +/- SEM) in e.d. l. and 16.8 +/- 1.7 s in soleus. The rate of decay depended on membrane potential: in e.d. l. , the 50% decay time was 14.3 +/- 0.7 s for contractures in 80 mM K (Vm = 25 mV) and 4.9 +/- 0.4 s in 160 mM K (Vm = -3 mV). In contrast to activation, which occurred with less depolarization in soleus fibers, steady state inactivation required more depolarization: after 3 min at -40 mV in 40 mM K, the 200 mM K contracture amplitude in e.d. l. fell to 28 +/- 10% (n = 5) of control, but remained at 85 +/- 2% (n = 6) of control in soleus. These different inactivation properties in e.d. l. and soleus fibers were not influenced by the fact that the 200 mM K solution used to test for steady state inactivation produced contractures that were maximal in soleus fibers but submaximal in e.d. l. : a relatively similar depression was recorded in maximal (200 mM K) and submaximal (60 and 80 mM K) contracture tension. A steady state "pedestal" of tension was observed with maintained depolarization after K contracture relaxation and was larger in soleus than in e.d. l. fibers. The pedestal tension was attributed to the overlap between the activation and inactivation curves for tension vs. membrane potential, which was greater in soleus than in e.d. l. fibers. The K contracture results were confirmed with the two- microelectrode voltage clamp: the contraction threshold increased to more positive potentials at holding potentials of -50 mV in e.d. l. or - 40 mV in soleus. At holding potentials of -30 mV in e.d. l. or 0 mV in soleus, contraction could not be evoked by 15-ms pulses to +20 mV. Both K contracture and voltage-clamp experiments revealed that activation in soleus fibers occurred with a smaller transient depolarization and was maintained with greater steady state depolarization than in e.d. l. fibers. The K contracture and voltage-clamp results are described by a model in which contraction depends on the formation of a threshold concentration of activator from a voltage-sensitive molecule that can exist in the precursor, activator, or inactive states.
FEASIBILITY OF DETECTING VOIDS WITH RAYLEIGH-WAVE DIFFRACTION

Void detection is challenging due to the complexity of near-surface materials and the limited resolution of geophysical methods. Although multichannel, high-frequency, surfacewave techniques can provide reliable S-wave velocities in different geological settings, they are not suitable for detecting voids directly based on anomalies of the S-wave velocity because of limitations on the resolution of S-wave velocity profiles inverted from surface-wave phase velocities. Therefore, we studied the feasibility of directly detecting voids with surface-wave diffractions. Based on the properties of surface waves, we have derived a Rayleigh-wave diffraction traveltime equation. We also have solved the equation for the depth to the top of a void and an average velocity of Rayleigh waves. Using these equations, the depth to the top of a void can be determined based on traveltime data from a diffraction curve. In practice, only two diffraction times are necessary to define the depth to the top of a void and the average Rayleigh-wave velocity that generates the diffraction curve. We used four two-dimensional square voids to demonstrate the feasibility of detecting a void with Rayleigh-wave diffractions: a 2 m by 2 m with a depth to the top of void of 2 m, 4 m by 4 m with a depth to the top of the void of 7 m, and 6 m by 6 m with depths to the top of the void 12 m and 17 m. Rayleigh-wave diffractions were recognizable for all these models after FK filtering was applied to the synthetic data. The Rayleigh-wave diffraction traveltime equation was verified by the modeled data. A real-world example is presented to show how to utilize the derived equation of surface-wave diffractions.
Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis. A review.

BACKGROUND Subantimicrobial dose doxycycline (SDD--20 mg doxycycline twice daily) is indicated as an adjunctive treatment for periodontitis. Doxycycline downregulates the activity of matrix metalloproteinases (MMPs), key destructive enzymes in periodontal disease. Current understanding of periodontal pathogenesis suggests that MMPs play a major role in the destruction of periodontal tissues, leading to the clinical signs of periodontitis. Research supports that downregulation of MMPs by SDD confers benefit to patients with periodontitis. METHOD We review the clinical, microbiological and safety data relating to the use of SDD in patients with periodontitis, and consider the historical events that led to the development of adjunctive SDD as a treatment for periodontitis. RESULTS Studies have shown that SDD, when prescribed as an adjunct to scaling and root planing (SRP), results in statistically and clinically significant gains in clinical attachment levels and reductions in probing depths over and above those that are achieved by SRP alone. SRP must be thorough and performed to the highest standard to maximise the benefits of adjunctive SDD. SDD does not result in antibacterial effects, or lead to the development of resistant strains or the acquisition of multiantibiotic resistance. The frequency of adverse events is low, and does not differ significantly from placebo. CONCLUSIONS Adjunctive SDD confers clinical benefit to patients with periodontitis. A comprehensive treatment strategy is suggested, involving patient education and motivation, reduction of the bacterial burden by SRP, host response modulation with SDD, and periodontal risk factor modification.
Sensor-actuator networks

Sensor-actuator networks (SANs) are a new approach for the physically-based animation of objects. The user supplies the configuration of a mechanical system that has been augmented with simple sensors and actuators. It is then possible to automatically discover many possible modes of locomotion for the given object. The SANs providing the control for these modes of locomotion are simple in structure and produce robust control. A SAN consists of a small non-linear network of weighted connections between sensors and actuators. A stochastic procedure for finding and then improving suitable SANs is given. Ten different creatures controlled by this method are presented. CR Categorias: G.3 [Probabuity and Statistics]: Probabilistic Algorithms; 1.2. 6 [Artificial Intelligence]: Learning, Robotics; 1.3. 7 [Computer Graphics]: Three-Dimensional Graphics and Realism animation; 1.6. 3 [Simulation and Modeling] Applications.
Auditory Multi-Stability: Idiosyncratic Perceptual Switching Patterns, Executive Functions and Personality Traits

Multi-stability refers to the phenomenon of perception stochastically switching between possible interpretations of an unchanging stimulus. Despite considerable variability, individuals show stable idiosyncratic patterns of switching between alternative perceptions in the auditory streaming paradigm. We explored correlates of the individual switching patterns with executive functions, personality traits, and creativity. The main dimensions on which individual switching patterns differed from each other were identified using multidimensional scaling. Individuals with high scores on the dimension explaining the largest portion of the inter-individual variance switched more often between the alternative perceptions than those with low scores. They also perceived the most unusual interpretation more often, and experienced all perceptual alternatives with a shorter delay from stimulus onset. The ego-resiliency personality trait, which reflects a tendency for adaptive flexibility and experience seeking, was significantly positively related to this dimension. Taking these results together we suggest that this dimension may reflect the individual’s tendency for exploring the auditory environment. Executive functions were significantly related to some of the variables describing global properties of the switching patterns, such as the average number of switches. Thus individual patterns of perceptual switching in the auditory streaming paradigm are related to some personality traits and executive functions.
Aspects of boundary-value problem solutions with three-dimensional dislocation dynamics

A three-dimensional discrete dislocation dynamics plasticity model is presented. The approach allows realistic boundary conditions on the specimen, as both stress and displacement fields of the dislocations are incorporated in the formulation. Emphasis is placed on various technical details in the formulation as well as on the implementation. The current implementation includes features necessary to model conservative motion of dislocations in presence of surfaces. These include details of the discretization of the evolving dislocation structure, the handling of junction formation and destruction, cross-slip and boundary conditions. Special attention is given to the treatment of dislocations that partly glide out of the material, including the treatment of image forces via the finite-element method.
Minimum Vertex Degree Threshold for C43 ‐tiling*

We prove that the vertex degree threshold for tiling C43 (the 3‐uniform hypergraph with four vertices and two triples) in a 3‐uniform hypergraph on n∈4N vertices is n−12−34n2+38n+c , where c=1 if n∈8N and c=−12 otherwise. This result is best possible, and is one of the first results on vertex degree conditions for hypergraph tiling.
Gliding Movements of Microtubule Driven by Kinesin Motors under External Force: Steering and Detachment

Kinesin and microtubule have been utilized for applications, such as molecular communication. In this paper, we describe a computer simulation which reproduced movements of microtubules gliding over kinesin-coated glass surfaces under external force. The simulation qualitatively reproduced experimental results of microtubule movements under external force. This simulation would enable understanding of details of the gliding movements of microtubules under external force.
Mechanical elastic constants and diffraction stress factors of macroscopically elastically anisotropic polycrystals: the effect of grain-shape (morphological) texture

The effect of the grain-shape (‘morphological’) texture of a polycrystal on the mechanical elastic constants and diffraction (X-ray) stress factors is investigated. To this end, the Eshelby–Kröner grain interaction model originally devised for polycrystals consisting of spherical grains is extended to ellipsoidal grain morphology. Results obtained for the mechanical elastic constants show that a polycrystal consisting of ellipsoidal grains with their principal axes aligned along common directions (i.e. when an ideal grain-shape texture occurs) is macroscopically elastically anisotropic. Also the diffraction (X-ray) stress factors are affected by the grain-shape texture; they reflect the macroscopic elastic anisotropy by resulting in nonlinear so-called sin2 ψ plots. In general, a grain-shape texture can have a moderate effect on the mechanical elastic constants and a pronounced effect on the diffraction elastic constants, depending on the crystal symmetry and single-crystal elastic anisotropy.
Understanding barriers to health care: a review of disparities in health care services among indigenous populations

Objectives. To review the current status of health care access and utilization among Indigenous people in the North America, Australia and New Zealand. Study Design. Literature review. Methods. A systematic search and critical review of relevant studies using online searches of electronic databases (PubMed, PsychINFO, MEDLINE) that examined issues relating to health care utilization and access. Results. Most studies found that health care access and utilization rates were found to be significantly lower among Indigenous populations. Factors such as rural location, communication and socio-economic status were found to be barriers to health care services that disproportionately affected Indigenous communities compared with the general population. Conclusions. Inequalities in health care access and utilization among Indigenous populations may play an important role in understanding why disparities in the health status of Indigenous populations continue to exist despite public health interventions. Further research is needed to understand the factors that contribute to these inequalities and to develop specific interventions to increase access and utilization among Indigenous populations.
Cancer incidence in the Swedish leather tanning industry: updated findings 1958–99

Aims: To assess how a 10 year extension of the follow up period affected cancer incidence in the Swedish leather tanning cohort. Methods: A cohort of 2027 tannery workers (of which 482 were women) who had been employed for at least one year between 1900 and 1989 at one of three Swedish leather tanneries, was established. The start of observation varied between 1958 and 1966 for the three plants. Through linkage with the Swedish Cancer Registry, incident cancer cases were recorded up to 1999. Cause specific expected cancer incidence was calculated for 1958–99 based on calendar year, sex, and five year age group specific incidence rates for the counties where the plants had been located. Altogether 56 022 person-years at risk were generated. Results: A total of 351 incident cancer cases were observed compared to 302 expected, which resulted in an increased standardised incidence ratio (SIR) of 1.16 (95% CI 1.04 to 1.29). An enhanced risk for prostate cancer was observed (SIR 1.44, 95% CI 1.10 to 1.86), mainly attributable to the later part of the observation period (1990–99). In this updated analysis the previously observed risk excess for soft tissue sarcomas was no longer significant (SIR 2.62, 95% CI 0.96 to 5.70). For multiple myelomas and sinonasal cancer the slight non-significant excesses remained, still based on very few cases. Conclusions: The increased risk for prostate cancer in the present study might be a chance finding, but is noteworthy, since it is in acccordance with the finding of increased SIR for prostate cancer among leather workers in another recent Swedish study. Moreover, excess risks for prostate cancer among farmers have been reported, indicating pesticides as possible causative agents. Leather tanners have also been exposed to pesticides.
Dremel

Dremel is a scalable, interactive ad hoc query system for analysis of read-only nested data. By combining multilevel execution trees and columnar data layout, it is capable of running aggregation queries over trillion-row tables in seconds. The system scales to thousands of CPUs and petabytes of data, and has thousands of users at Google. In this paper, we describe the architecture and implementation of Dremel, and explain how it complements MapReduce-based computing. We present a novel columnar storage representation for nested records and discuss experiments on few-thousand node instances of the system.
Large N expansion of convergent matrix integrals, holomorphic anomalies, and background independence

We propose an asymptotic expansion formula for matrix integrals, including oscillatory terms (derivatives of theta-functions) to all orders. This formula is heuristically derived from the analogy between matrix integrals, and formal matrix models (combinatorics of discrete surfaces), after summing over filling fractions. The whole oscillatory series can also be resummed into a single theta function. We also remark that the coefficients of the theta derivatives, are the same as those which appear in holomorphic anomaly equations in string theory, i.e. they are related to degeneracies of Riemann surfaces. Moreover, the expansion presented here, happens to be independent of the choice of a background filling fraction.
Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015

Major β-thalassemia (β-TM) is one of the most common inherited hemolytic types of anemia which is caused as a result of absent or reduced synthesis of β-globin chains of hemoglobin. This defect results in red blood cells lysis and chronic anemia that can be treated by multiple blood transfusions and iron chelation therapy. Without iron chelation therapy, iron overload will cause lots of complications in patients. Antioxidant components play an important role in the treatment of the disease. Silymarin is an antioxidant flavonoid isolated from Silybum marianum plant. In the present study, we reviewed clinical and experimental studies investigating the use of silymarin prior to September 1, 2015, using PubMed, ISI Web of Knowledge, Science Direct, Scopus, Ovid, and Cochrane Library databases and we evaluated the potential effects of silymarin on controlling the complications induced by iron overload in patients with β-TM. Based on the results of the present study, we can conclude that silymarin may be useful as an adjuvant for improving multiple organ dysfunctions.
Liver Graft Regeneration in Right Lobe Adult Living Donor Liver Transplantation

Optimal portal flow is one of the essentials in adequate liver function, graft regeneration and outcome of the graft after right lobe adult living donor liver transplantation (ALDLT). The relations among factors that cause sufficient liver graft regeneration are still unclear. The aim of this study is to evaluate the potential predisposing factors that encourage liver graft regeneration after ALDLT. The study population consisted of right lobe ALDLT recipients from Chang Gung Memorial Hospital‐Kaohsiung Medical Center, Taiwan. The records, preoperative images, postoperative Doppler ultrasound evaluation and computed tomography studies performed 6 months after transplant were reviewed. The volume of the graft 6 months after transplant divided by the standard liver volume was calculated as the regeneration ratio. The predisposing risk factors were compiled from statistical analyses and included age, recipient body weight, native liver disease, spleen size before transplant, patency of the hepatic venous graft, graft weight‐to‐recipient weight ratio (GRWR), posttransplant portal flow, vascular and biliary complications and rejection. One hundred forty‐five recipients were enrolled in this study. The liver graft regeneration ratio was 91.2 ± 12.6% (range, 58–151). The size of the spleen (p = 0.00015), total portal flow and GRWR (p = 0.005) were linearly correlated with the regeneration rate. Patency of the hepatic venous tributary reconstructed was positively correlated to graft regeneration and was statistically significant (p = 0.017). Splenic artery ligation was advantageous to promote liver regeneration in specific cases but splenectomy did not show any positive advantage. Spleen size is a major factor contributing to portal flow and may directly trigger regeneration after transplant. Control of sufficient portal flow and adequate hepatic outflow are important factors in graft regeneration.