Miracle-dz/UniFAR-FTUs huggingface dataset:
The Concordance of Self-Report With Other Measures of Medication Adherence: A Summary of the Literature

Objective:The objective of this study was to evaluate the concordance of self-report measures of medication adherence (interview, diary, or questionnaire) with nonself-report measures of adherence (administrative claims, pill count or canister weight, plasma drug concentration, electronic monitors, or clinical opinion). Methods:A literature search was conducted to identify published reports in which self-report and nonself-report measures of adherence were used within the same study. The concordance of measures within each study was categorized as high, moderate, or low based on a comparison of the adherence estimates. Results:Eight-six comparisons of self-report to nonself-report measures of adherence were identified. Thirty-seven of the 86 comparisons (43%) were categorized as highly concordant. However, concordance varied substantially by type of self-report measure and nonself-report measure. Self-report measures, in general, were highly concordant with electronic measures in only 17% of comparisons, whereas they were highly concordant with other types of nonself-report measures in 58% of comparisons (chi-square = 14.30, P <0.01). When comparing self-report measures, interviews had significantly lower concordance with nonself-report measures as compared with questionnaires or diaries (chi-square = 8.47, P = 0.01). In 15 comparisons of interviews with electronic measures, none of the comparisons were highly concordant, whereas questionnaires and diaries had moderate-to-high concordance with electronic measures in 12 of 16 comparisons (75%). Conclusions:The concordance of self-report and other measures of medication adherence varies widely based on the type of measures used. Questionnaires and diaries tend to have moderate-to-high concordance with other measures of medication adherence. However, interview-based self-reports are not concordant with electronic measures. Questionnaire and diary methods could be preferable to interviews for self-reported medication adherence.
The Effect of Ambient Scent on the Experience of Art: Not as Good as It Smells

This study examines the impact of ambient scent on the perception and memory of art, in terms of perceived valence, arousal, and remembering of artworks. Because art perception evokes emotions and embodiment, the experiential marketing literature suggests using sensorial stimuli to enhance the experience of visiting art exhibitions. Although a fragrance in the environment can make visiting enjoyable, we examine more specifically the effects of scent on perception and memory of art, including potential interactions between different scents and artworks. In a between-participant experiment, this study shows some counterintuitive effects of scent on both evaluation and memory of art: a pleasant ambient scent can decrease evaluations of artworks and hinder memory of those artworks. Furthermore, scent and art have an interactive effect on arousal, such that incongruent scents and artworks increase arousal relative to congruent scents and artworks. In conclusion, enhancing experiences through sensorial cues can counterintuitively hinder the evaluation and memory of art. To the extent that art institutions aim to spread knowledge and appreciation of art, managers should be aware that ambient scents can actually interfere with this mission.
Mutations of the CFTR gene in Turkish patients with congenital bilateral absence of the vas deferens.

BACKGROUND Mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) can cause congenital bilateral absence of the vas deferens (CBAVD) as a primarily genital form of cystic fibrosis. The spectrum and frequency of CFTR mutations in Turkish males with CBAVD is largely unknown. METHODS We investigated 51 Turkish males who had been diagnosed with CBAVD at the Hacettepe University, Ankara, for the presence of CFTR gene mutations by direct sequencing of the coding region and exon/intron boundaries. RESULTS We identified 27 different mutations on 72.5% of the investigated alleles. Two-thirds of the patients harboured CFTR gene mutations on both chromosomes. Two predominant mutations, IVS8-5T and D1152H, accounted for more than one-third of the alleles. Five mutations are described for the first time. With one exception, all identified patients harboured at least one mutation of the missense or splicing type. Presently available mutation panels would have uncovered only 7-12% of CFTR alleles in this population cohort. CONCLUSIONS Although cystic fibrosis is relatively rare in Turkey, CFTR mutations are responsible for the majority of CBAVD in Turkish males. Because of a specific mutation profile, a population-specific panel should be recommended for targeted populations such as CBAVD in Turkey or elsewhere.
Efficient NURBS Rendering using View-Dependent LOD and Normal Maps

Rendering large trimmed NURBS models with high quality at interactive frame rates is of great interest for industry, since nearly all their models are designed on the basis of this surface type. Most existing approaches transform the NURBS surfaces into polygonal representation and build static levels of detail. Unfortunately, algorithms which keep the NURBS representation and generate view-dependent LOD on the fly suffer from the problem, that they only calculate the geometric error of an approximation, but no care is taken of the illumination artefacts introduced by the chosen view-dependent triangulation. Normal maps have proven to be very accurate in providing better visual quality without increasing the complexity of the geometry itself and thus solving this problem, but need much memory to store the normal textures. In this paper we present a novel approach to apply normal maps to view-depandent NURBS rendering with small memory and computational overhead. Additionally, we apply our approach to render isophotes and environment maps such as reflection lines on view dependent triangulations with high visual fidelity.
Dependence of entropy on volume for silicate and oxide minerals : A review and a predictive model

Simple quantum models (Einstein and Debye) of lattice heat capacity and entropy may be used to predict the magnitude of the dependence of entropy on volume for silicate minerals. The origins for the volume effect as well as the effect of variation in coordination state of cation polyhedra on the thirdlaw entropy are explored and rationalized within the framework of simple lattice-vibration theory. It is shown that Einstein and Debye theories for solids predict a value for (05/0V)r^ of about 1.0 J'K-''cm-3, precisely the value found from regression of a set of 60 experimentally measured entropies and volumes of silicates and oxides. An additive model for estimating the entropies of mineral endmembers at 298 K, based upon the scheme advocated by Fyfe, Turner, and Verhoogen (1958), but allowing for coordination changes, is developed and evaluated by multiple regression of this body of measured data. The entropy-volume-coordination model fits these data better than any previously published scheme and works remarkably well even for transition metal-bearing phases when allowance for magnetic disordering is made. Phases such as magnetite and hematite that undergo magnetic disorder at temperatures above 298 K can be accommodated within the model by correcting for the partial disorder at 298 K using simple Landau theory. The model predicts silicate and oxide entropies in the system K. ,O-NarO-CaO-MgO-FeO-FerO. -MnO-TiOr-AlrO3-SiO, with uncertainties typically in the range of 0-2o/o, even for the Fe-, Mn-, and Ti-bearing phases.
Tumor-Derived IL-35 Promotes Tumor Growth by Enhancing Myeloid Cell Accumulation and Angiogenesis

IL-35 is a member of the IL-12 family of cytokines that is comprised of an IL-12 p35 subunit and an IL-12 p40-related protein subunit, EBV-induced gene 3 (EBI3). IL-35 functions through IL-35R and has a potent immune-suppressive activity. Although IL-35 was demonstrated to be produced by regulatory T cells, gene-expression analysis revealed that it is likely to have a wider distribution, including expression in cancer cells. In this study, we demonstrated that IL-35 is produced in human cancer tissues, such as large B cell lymphoma, nasopharyngeal carcinoma, and melanoma. To determine the roles of tumor-derived IL-35 in tumorigenesis and tumor immunity, we generated IL-35–producing plasmacytoma J558 and B16 melanoma cells and observed that the expression of IL-35 in cancer cells does not affect their growth and survival in vitro, but it stimulates tumorigenesis in both immune-competent and Rag1/2-deficient mice. Tumor-derived IL-35 increases CD11b+Gr1+ myeloid cell accumulation in the tumor microenvironment and, thereby, promotes tumor angiogenesis. In immune-competent mice, spontaneous CTL responses to tumors are diminished. IL-35 does not directly inhibit tumor Ag–specific CD8+ T cell activation, differentiation, and effector functions. However, IL-35–treated cancer cells had increased expression of gp130 and reduced sensitivity to CTL destruction. Thus, our study indicates novel functions for IL-35 in promoting tumor growth via the enhancement of myeloid cell accumulation, tumor angiogenesis, and suppression of tumor immunity.
Kinetics of oxygen uptake during supine and upright heavy exercise.

It is presently unclear how the fast and slow components of pulmonary oxygen uptake (VO(2)) kinetics would be altered by body posture during heavy exercise [i.e., above the lactate threshold (LT)]. Nine subjects performed transitions from unloaded cycling to work rates representing moderate (below the estimated LT) and heavy exercise (VO(2) equal to 50% of the difference between LT and peak VO(2)) under conditions of upright and supine positions. During moderate exercise, the steady-state increase in VO(2) was similar in the two positions, but VO(2) kinetics were slower in the supine position. During heavy exercise, the rate of adjustment of VO(2) to the 6-min value was also slower in the supine position but was characterized by a significant reduction in the amplitude of the fast component of VO(2), without a significant slowing of the phase 2 time constant. However, the amplitude of the slow component was significantly increased, such that the end-exercise VO(2) was the same in the two positions. The changes in VO(2) kinetics for the supine vs. upright position were paralleled by a blunted response of heart rate at 2 min into exercise during supine compared with upright heavy exercise. Thus the supine position was associated with not only a greater amplitude of the slow component for VO(2) but also, concomitantly, with a reduced amplitude of the fast component; this latter effect may be due, at least in part, to an attenuated early rise in heart rate in the supine position.
Review and Classification of Multichannel MAC Protocols for Low-Power and Lossy Networks

The so-called Internet of Things (IoT) aims at connecting every single object to the Internet with the purpose to automate every aspect of daily life. The IoT relies heavily on wireless low-power and lossy networks (LLNs) that collect information from the physical world and send the measurements to data aggregation and processing nodes. Most LLNs operate in the non-licensed industrial, scientific, and medical radio band, which is shared by a considerable number of systems. Coexisting wireless systems cause interference to each other, limiting their achievable performance. Multichannel communications enable frequency diversity, which in turn provides robustness against interference as well as increased network capacity. There is a considerable interest in multichannel medium access control (MAC) protocols for LLNs, including an evolving standard for the MAC layer of LLNs. In this paper, we review the latest advances in the topic and introduce a new classification framework for multichannel MAC protocols for LLNs. While our framework builds on previous review and classification studies, it adds aspects of a MAC protocol that reflect its interactions with the surrounding network stack. Seeing the resource constraints of the LLN devices, the study of such interactions—which is missing in prior classification efforts—can be the key for improving future designs. Relevant protocols published since 2006 are discussed and classified using the presented framework, including the recent multichannel MAC protocols for LLNs, such as the latest version of the IEEE 802.15. 4 standard for time slotted channel hopping.
New self-similar solutions of polytropic gas dynamics

We explore semicomplete self-similar solutions for the polytropic gas dynamics involving self-gravity under spherical symmetry, examine behaviours of the sonic critical curve and present new asymptotic collapse solutions that describe ‘quasi-static’ asymptotic behaviours at small radii and large times. These new ‘quasi-static’ solutions with divergent mass density approaching the core can have self-similar oscillations. Earlier known solutions are summarized. Various semicomplete self-similar solutions involving such novel asymptotic solutions are constructed, either with or without a shock. In contexts of stellar core collapse and supernova explosion, a hydrodynamic model of a rebound shock initiated around the stellar degenerate core of a massive progenitor star is presented. With this dynamic model framework, we attempt to relate progenitor stars and the corresponding remnant compact stars: neutron stars, black holes and white dwarfs.
PENGARUH BUDGETARY PARTICIPATION, INFORMATION ASYMMETRY, BUDGET EMPHASIS, DAN SELF ESTEEM TERHADAP BUDGETARY SLACK

Penelitian ini bertujuan untuk mengetahui dan memperoleh bukti empiris mengenai ada tidaknya pengaruh signifikan variabel budgetary participation , information asymmetry , budget emphasis , dan self esteem terhadap budgetary slack . Penelitian ini dilakukan dengan menggunakan bantuan software SPSS 19. Sebelum melakukan pengujian hipotesis dilakukan uji validitas dan reliabilitas untuk memastikan validitas dan keandalan data yang diperoleh dari kuesioner, serta pengujian asumsi klasik untuk memastikan pengujian hipotesis layak dilakukan. Pengujian hipotesis dilakukan dengan uji regresi. Dengan tingkat keyakinan 95%, hasil pengujian regresi linier menyatakan bahwa variabel budgetary participation, budget emphasis , dan self esteem masing-masing memiliki pengaruh yang signifikan terhadap budgetary slack , dan menunjukkan hubungan positif, sedangkan information asymmetry tidak memiliki pengaruh yang signifikan terhadap budgetary slack . Hasil pengujian regresi berganda menunjukkan bahwa variabel budgetary participation, information asymmetry, budget emphasis , dan self esteem secara bersama-sama memiliki pengaruh yang signifikan terhadap budgetary slack , dan menunjukkan hubungan positif. Penelitian selanjutnya disarankan untuk membatasi sampel penelitian pada industri tertetu saja dan juga menggunakan variabel-variabel lain, seperti budaya organisasi, pertimbangan etika dan reputasi, persaingan dalam perusahaan, social pressure , serta risk aversion yang dapat mempengaruhi budgetary slack
Database Replication with Availability and Consistency Guarantees through Failure-Handling

In this paper we present an approach to fault-tolerant stream processing. In contrast to previous techniques that handle node failures, our approach also tolerates network failures and network partitions. The approach is based on a principled trade-off between consistency and availability in the face of failure, that (1) ensures that all data on an input stream is processed within a specified time threshold, but (2) reduces the impact of failures by limiting if possible the number of results produced based on partially available input data, and (3) corrects these results when failures heal. Our approach is well-suited for applications such as environment monitoring, where high availability and "real-time" response is preferable to perfect answers. Our approach uses replication and guarantees that all processing replicas achieve state consistency, both in the absence of failures and after a failure heals. We achieve consistency in the former case by defining a data-serializing operator that ensures that the order of tuples to a downstream operator is the same at all the replicas. To achieve consistency after a failure heals, we develop approaches based on checkpoint/redo and undo/redo techniques.
Marked Alteration of Rosuvastatin Pharmacokinetics in Healthy Chinese with ABCG2 34G>A and 421C>A Homozygote or Compound Heterozygote

Rosuvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor used to lower blood low-density lipoprotein cholesterol, is a substrate of the membrane ABCG2 exporter. ABCG2 variants have been shown to alter rosuvastatin disposition. The objective of this study is to determine the impact of ABCG2 34/421 compound haplotypes on rosuvastatin pharmacokinetics in healthy Chinese volunteer subjects. Eight hundred healthy Chinese males were genotyped by polymerase chain reaction–pyrosequencing for ABCG2 34G>A, ABCG2 421C>A, SLCO1B1 521T>C, and CYP2C9*3 variants. Sixty-two male subjects with wild-type SLCO1B1 c.521TT and CYP2C9*3 were recruited for this pharmacokinetic study of rosuvastatin. A single oral dose of 10 mg rosuvastatin was administrated to each subject, and blood samples were collected before and at various time points after drug administration. Plasma concentration of rosuvastatin was determined by high-performance liquid chromatography–tandem mass spectrometry, and pharmacokinetic analysis was carried out using the WinNonlin program. In Chinese males, high allele frequency of ABCG2 c.34G>A (0.275) and c.421C>A (0.282) was observed, resulting in a considerable portion (23.3%) of subjects being ABCG2 34/421 compound heterozygotes. Compared with subjects with ABCG2 wild-type (c.34GG/421CC), plasma rosuvastatin Cmax and area under the curve, AUC0–∞, were significantly higher, while the apparent oral clearance, CL/F, was significantly lower in subjects with c.34AA, c.421AA, and c.34GA/421CA genotypes. Both t1/2 and Tmax were similar among subjects with different genotypes. A high frequency of ABCG2 c.34G>A and c.421C>A variants was present in Chinese males, and the disposition of rosuvastatin was significantly affected by both variants. These data suggest that it is advisable to genotype these variants when prescribing rosuvastatin to Chinese subjects, leading to a precise dose for each individual.
Adenoviral vector demonstrates that angiotensin II‐induced depression of the cardiac baroreflex is mediated by endothelial nitric oxide synthase in the nucleus tractus solitarii of the rat

1 Angiotensin II (ANGII) acting on ANGII type 1 (AT1) receptors in the solitary tract nucleus (NTS) depresses the baroreflex. Since ANGII stimulates the release of nitric oxide (NO), we tested whether the ANGII‐mediated depression of the baroreflex in the NTS depended on NO release. 2 In a working heart‐brainstem preparation (WHBP) of rat NTS microinjection of either ANGII (500 fmol) or a NO donor (diethylamine nonoate, 500 pmol) both depressed baroreflex gain by ‐56 and ‐67 %, respectively (P < 0.01). In contrast, whilst ANGII potentiated the peripheral chemoreflex, the NO donor was without effect. 3 NTS microinjection of non‐selective NO synthase (NOS) inhibitors (l‐NAME; 50 pmol) or (l‐NMMA; 200 pmol) prevented the ANGII‐induced baroreflex attenuation (P > 0.1). In contrast, a neurone‐specific NOS inhibitor, TRIM (50 pmol), was without effect. 4 Using an adenoviral vector, a dominant negative mutant of endothelial NOS (TeNOS) was expressed bilaterally in the NTS. Expression of TeNOS affected neither baseline cardiovascular parameters nor baroreflex sensitivity. However, ANGII microinjected into the transfected region failed to affect the baroreflex. 5 Immunostaining revealed that eNOS‐positive neurones were more numerous than those labelled for AT1 receptors. Neurones double labelled for both AT1 receptors and eNOS comprised 23 ± 5.4 % of the eNOS‐positive cells and 57 ± 9.2 % of the AT1 receptor‐positive cells. Endothelial cells were also double labelled for eNOS and AT1 receptors. 6 We suggest that ANGII activates eNOS located in either neurones and/or endothelial cells to release NO, which acts selectively to depress the baroreflex.
Histological Changes of the Ovary in Pregnant Mice Vaginally Exposed to Toxoplasma gondii

Background: Congenital toxoplasmosis is one cause of abortion. Infection can disrupt ovarian cycles and because toxoplasmosis is an infectious disease may have a similar effect on the ovaries. The purpose of this study was to investigate the pathological changes in the ovaries due to toxoplasmosis. Methods: Tachyzoites of Toxoplasma gondii were harvested from peritoneal fluid of mice, experimentally infected. Two females and one male mouse were housed per cage for mating in the overnight. The pregnant mice were divided into experimental and control groups. Experimental group were infected by parasite but the control group received the normal saline. The experimental and control mice were euthanized. Ovaries and uterine horns of animals were removed and prepared for light microscopy. Results: Ovaries of infected pregnant mice presented gross morphological differences compared to the control groups. In ovaries of experimental groups, changes of corpus luteum were observed. The comparison of experimental and control groups revealed that the number of primary follicles, secondary follicle, atretic primary follicles and atretic secondary follicles had significant differences (P≤0.001). Conclusion: Toxoplasma gondii alters ovarian follicular growth and development in mice. In addition, it alters number of different phases of follicles and corpus luteum in ovaries of mice.
Correlation between package-level ball impact test and board-level drop test

Package-level ball impact test and board-level drop test are performed and correlated empirically using a specific chip-scale package with solder joints of different Sn-Ag-Cu solder compositions. A positive correlation is found between characteristics of the impact force profile and reliability from the drop test, which provides a supporting basis for the package-level ball impact test to serve as a substitute of the timely and costly board-level drop test
Behavioral Phenotyping of Mixed Background (129S5:B6) Relaxin‐3 Knockout Mice

Experimental studies in rats have revealed that the neuropeptide relaxin‐3 modulates feeding and metabolism, stress responses, arousal, and exploratory behavior. In the present study, two cohorts of mixed background (129S5:B6) relaxin‐3 knockout (KO) and wild‐type littermate mice were subjected to a series of behavioral tests. Relaxin‐3 KO mice appeared healthy and displayed no genotype differences in body weight, motor coordination (as determined via the rotarod), anxiety (light/dark box, elevated plus maze, large open field), spatial memory (Y‐maze), or sensorimotor gating (prepulse inhibition). Female KO mice did, however, display hypoactivity, reflected by significantly shorter distances traveled in the automated locomotor cell, large open field, and novel object tests, and had fewer encounters with a novel mouse in a social interaction test. Male KOs, on the other hand, displayed a “hypersensitivity” to stress, spending longer in the Porsolt posture during a repeated forced swim test and losing a significantly greater percentage of their body weight in response to an 8‐week chronic stress regimen. These findings support the hypothesis that relaxin‐3 signaling contributes to the central control of arousal, exploratory behavior and stress responses.