Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comprehensive Methodology for Development, Parameter Estimation, and Uncertainty Analysis of Group Contribution Based Property Models—An Application to the Heat of Combustion

A rigorous methodology is developed that addresses numerical and statistical issues when developing group contribution (GC) based property models such as regression methods, optimization algorithms, performance statistics, outlier treatment, parameter identifiability, and uncertainty of the prediction. The methodology is evaluated through development of a GC method for the prediction of the heat of combustion (ΔHco) for pure components. The results showed that robust regression lead to best performance statistics for parameter estimation. The bootstrap method is found to be a valid alternative to calculate parameter estimation errors when underlying distribution of residuals is unknown. Many parameters (first, second, third order group contributions) are found unidentifiable from the typically available data, with large estimation error bounds and significant correlation. Due to this poor parameter identifiability issues, reporting of the 95% confidence intervals of the predicted property values should be.
Spotlight into some Abnormalities of Human Chromosome in Saudi Arabia

Middle Eastern cultures are tribal and heavily consanguineous. Marriage between cousins has been part of the culture for millennia leading to "founder" effect and a large number of genetic diseases. Chromosomal abnormalities are the results of alterations in the number or structure of chromosomes causing significant human morbidity and mortality. They are responsible for a large proportion of miscarriages, developmental delay, and disorders of sexual development, congenital malformations and mental retardation. The aim of this study is to screen some of these frequent observed common chromosomal disorders and try to identify the significant reason behind the increase or present of these diseases in our community. Data collection and survey study into different local hospital in Riyadh and cytogenetic lab with a variety of clinical disorders; Down syndrome (DS), Turner’s syndrome (TS) and Klinefelter syndrome; amenorrhea; ambiguous sex and multiple congenital malformations. The most common autosomal abnormalities were DS. Numerical abnormalities were accounted for 353 (41.0%) and structural abnormalities 18 (2.0%), respectively. Various other chromosomal anomalies were also reported. We have reviewed the incidence and distribution of chromosomal abnormalities and found higher rate of chromosomal abnormalities 43.1% in the referred cases. Our data suggest that chromosomal analysis is important tool in the evaluation of genetic disorders but lack of genetic counseling did not help to understand the high frequency of such rare genetic disorder in our community.
Testing a Moderated Mediation Model of Transformational Leadership, Values, and Organization Change

A field study of organizational leaders and their immediate followers was conducted to investigate (a) the mediating roles of follower openness to change values and follower self-transcendence values in linking transformational leadership to follower change resistance and follower extra effort, respectively and (b) the moderating role of organization change magnitude in influencing the mediation effects. Transformational leadership theory postulates that a range of follower attitudinal and performance outcomes are at least partially explained by a leader’s ability to influence followers’ values to support organizational change. Using Preacher, Rucker, and Hayes’s moderated mediation framework, this study extends transformational leadership research by testing a model that explicates the roles of leader behavior, follower values, and a key contextual variable in producing effects on follower attitudinal and performance outcomes. Data from 181 organizational leaders and 723 of their respective followers demonstrated strong support for the moderated mediation model. The conditional indirect effects of transformational leadership on follower change resistance and follower extra effort via follower openness to change and self-transcendence values, respectively, were stronger in work contexts characterized by high organization change magnitude. Implications for theory, future research, and practice are discussed.
Which Contributions Predict Whether Developers are Accepted into GitHub Teams

Open-source software (OSS) often evolves from volunteer contributions, so OSS development teams must cooperate with their communities to attract new developers. However, in view of the myriad ways that developers interact over platforms for OSS development, observers of these communities may have trouble discerning, and thus learning from, the successful patterns of developer-to-team interactions that lead to eventual team acceptance. In this work, we study project communities on GitHub to discover which forms of software contribution characterize developers who begin as development team outsiders and eventually join the team, in contrast to developers who remain team outsiders. From this, we identify and compare the forms of contribution, such as pull requests and several forms of discussion comments, that influence whether new developers join OSS teams, and we discuss the implications that these behavioral patterns have for the focus of designers and educators.
Retrospective study of survival in human papillomavirus-negative oropharyngeal squamous cell carcinoma treated with primary surgery and associated prognostic factors

Background Oropharyngeal squamous cell carcinoma (OPSCC) is an aggressive malignancy which has been investigated for decades and reported highly associated with the human papillomavirus (HPV) infection, yet there is no consensus reached on the optimal treatment paradigm. The relatively lower prevalence of HPV in China makes it important to evaluate the outcomes of HPV-negative OPSCC. Purpose Our study was carried out in an attempt to evaluate the outcomes of squamous cell carcinoma of the oropharynx treated with primary surgery and identify the associated prognostic factors. Patients and methods We retrospectively analyzed the outcomes of the primary surgically treated HPV-negative OPSCC cases at our institution between 2008 and 2013. Overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were determined by Kaplan–Meier analysis. Prognostic factors of outcomes were investigated by uni- and multivariate analyses. Results In this study, neck metastasis rate was 61.3%. Level II nodes were the most vulnerable. The 3-year disease-specific survival, overall survival, and disease-free survival rates were 76.7%, 75.6%, and 62.8%, respectively. Forearm free flaps were the most commonly utilized in the reconstructions. A multivariate analysis indicated that N stage and adjuvant radiotherapy were predictive factors for 3-year disease-specific survival. Conclusion The outcomes of the surgical treatment of oropharyngeal squamous cell carcinoma were acceptable, and N-stage, adjuvant radiotherapy were identified as prognostic factors.
What is the effect of prolonged sitting and physical activity on thoracic spine mobility? An observational study of young adults in a UK university setting

Objective Sedentary behaviour has long been associated with neck and low back pain, although relatively little is known about the thoracic spine. Contributing around 33% of functional neck movement, understanding the effect of sedentary behaviour and physical activity on thoracic spinal mobility may guide clinical practice and inform research of novel interventions. Design An assessor-blinded prospective observational study designed and reported in accordance with Strengthening the Reporting of Observational Studies in Epidemiology. Setting UK university (June–September 2016). Participants A convenience sample (18–30 years) was recruited and based on self-report behaviours, the participants were assigned to one of three groups: group 1, sitters—sitting >7 hours/day+physical activity<150 min/week; group 2, physically active—moderate exercise >150 min/week+sitting <4 hours/day and group 3, low activity—sitting 2–7 hours/day+physical activity <150 min/week. Outcome measures Thoracic spine mobility was assessed in the heel-sit position using Acumar digital goniometer; a validated measure. Descriptive and inferential analyses included analysis of variance and analysis of covariance for between group differences and Spearman’s rank correlation for post hoc analysis of associations. Results The sample (n=92) comprised: sitters n=30, physically active n=32 and low activity n=30. Groups were comparable with respect to age and body mass index. Thoracic spine mobility (mean (SD)) was: group 1 sitters 64.75 (1.20), group 2 physically active 74.96 (1.18) and group 3 low activity 68.44 (1.22). Significant differences were detected between (1) sitters and low activity, (2) sitters and physically active (p<0.001). There was an overall effect size of 0.31. Correlations between thoracic rotation and exercise duration (r=0.67, p<0.001), sitting duration (r=−0.29, p<0.001) and days exercised (r=0.45, p<0.001) were observed. Conclusions Findings evidence reduced thoracic mobility in individuals who spend >7 hours/day sitting and <150 min/week of physical activity. Further research is required to explore possible causal relationships between activity behaviours and spinal musculoskeletal health.
Relationship of Handgrip Strength and Body Mass Index With Cognitive Function in Patients With Schizophrenia

Background: The relationship between muscle strength and cognition in schizophrenia has not been well studied. We investigated the potential relationship of handgrip strength (HGS) score and body mass index (BMI) with cognitive function in patients with schizophrenia. Methods: Participants included 153 patients with schizophrenia (age: 36.9 ± 9.4 years; 82 males) and 328 healthy controls (age: 36.4 ± 10.7 years; 150 males), matched for age, sex, and ethnicity (Japanese). HGS was measured using a digital handgrip dynamometer. Cognitive function was evaluated using the Brief Assessment of Cognition in Schizophrenia (BACS) test. A two-way multivariate analysis of covariance was used to compare HGS scores between the patient and control groups. Multiple regression analyses of BACS scores were performed in the patient and control groups using HGS and BMI scores as independent variables. Results: In the intergroup comparison, significantly lower HGS scores were observed in patients with schizophrenia than in healthy controls (p < 0.05, corrected). In the patient group, there was a significantly positive correlation between HGS scores and BACS composite score (male, p = 0.0014; female, p = 0.0051). However, BMI scores were significantly negatively correlated with the BACS composite score (male, p = 0.0022; female, p = 0.018). Furthermore, the ratio of HGS/BMI was significantly positively correlated with the BACS composite score in the patient group (p = 0.00000018). Conclusions: Cognitive function in patients with schizophrenia is correlated positively with HGS and negatively with BMI. HGS/BMI may thus be a good index for cognitive performance in schizophrenia.
Source attribution of human campylobacteriosis at the point of exposure by combining comparative exposure assessment and subtype comparison based on comparative genomic fingerprinting

Human campylobacteriosis is a common zoonosis with a significant burden in many countries. Its prevention is difficult because humans can be exposed to Campylobacter through various exposures: foodborne, waterborne or by contact with animals. This study aimed at attributing campylobacteriosis to sources at the point of exposure. It combined comparative exposure assessment and microbial subtype comparison with subtypes defined by comparative genomic fingerprinting (CGF). It used isolates from clinical cases and from eight potential exposure sources (chicken, cattle and pig manure, retail chicken, beef, pork and turkey meat, and surface water) collected within a single sentinel site of an integrated surveillance system for enteric pathogens in Canada. Overall, 1518 non-human isolates and 250 isolates from domestically-acquired human cases were subtyped and their subtype profiles analyzed for source attribution using two attribution models modified to include exposure. Exposure values were obtained from a concurrent comparative exposure assessment study undertaken in the same area. Based on CGF profiles, attribution was possible for 198 (79%) human cases. Both models provide comparable figures: chicken meat was the most important source (65–69% of attributable cases) whereas exposure to cattle (manure) ranked second (14–19% of attributable cases), the other sources being minor (including beef meat). In comparison with other attributions conducted at the point of production, the study highlights the fact that Campylobacter transmission from cattle to humans is rarely meat borne, calling for a closer look at local transmission from cattle to prevent campylobacteriosis, in addition to increasing safety along the chicken supply chain.
The makings of the ‘actin code': regulation of actin's biological function at the amino acid and nucleotide level

ABSTRACT The actin cytoskeleton plays key roles in every eukaryotic cell and is essential for cell adhesion, migration, mechanosensing, and contractility in muscle and non-muscle tissues. In higher vertebrates, from birds through to mammals, actin is represented by a family of six conserved genes. Although these genes have evolved independently for more than 100 million years, they encode proteins with ≥94% sequence identity, which are differentially expressed in different tissues, and tightly regulated throughout embryogenesis and adulthood. It has been previously suggested that the existence of such similar actin genes is a fail-safe mechanism to preserve the essential function of actin through redundancy. However, knockout studies in mice and other organisms demonstrate that the different actins have distinct biological roles. The mechanisms maintaining this distinction have been debated in the literature for decades. This Review summarizes data on the functional regulation of different actin isoforms, and the mechanisms that lead to their different biological roles in vivo. We focus here on recent studies demonstrating that at least some actin functions are regulated beyond the amino acid level at the level of the actin nucleotide sequence. Summary: We propose a new concept, the actin code, which encompasses the regulation of the essential functions of mammalian actins at the nucleotide level, rather than at the level of amino acids.
Privacy Pass: Bypassing Internet Challenges Anonymously

Abstract The growth of content delivery networks (CDNs) has engendered centralized control over the serving of internet content. An unwanted by-product of this growth is that CDNs are fast becoming global arbiters for which content requests are allowed and which are blocked in an attempt to stanch malicious traffic. In particular, in some cases honest users-especially those behind shared IP addresses, including users of privacy tools such as Tor, VPNs, and I2P - can be unfairly targeted by attempted ‘catch-all solutions’ that assume these users are acting maliciously. In this work, we provide a solution to prevent users from being exposed to a disproportionate amount of internet challenges such as CAPTCHAs. These challenges are at the very least annoying and at their worst - when coupled with bad implementations - can completely block access from web resources. We detail a 1-RTT cryptographic protocol (based on an implementation of an oblivious pseudorandom function) that allows users to receive a significant amount of anonymous tokens for each challenge solution that they provide. These tokens can be exchanged in the future for access without having to interact with a challenge. We have implemented our initial solution in a browser extension named “Privacy Pass”, and have worked with the Cloudflare CDN to deploy compatible server-side components in their infrastructure. However, we envisage that our solution could be used more generally for many applications where anonymous and honest access can be granted (e.g., anonymous wiki editing). The anonymity guarantee of our solution makes it immediately appropriate for use by users of Tor/VPNs/ I2P. We also publish figures from Cloudflare indicating the potential impact from the global release of Privacy Pass.
Expression of Regeneration‐Associated Proteins in Primary Sensory Neurons and Regenerating Axons After Nerve Injury—An Overview

Peripheral nerve injury results in profound alterations of the affected neurons resulting from the interplay between intrinsic and extrinsic molecular events. Restarting the neuronal regenerative program is an important prerequisite for functional recovery of the injured peripheral nerve. The primary sensory neurons with their cell bodies in the dorsal root ganglia provide a useful in vivo and in vitro model for studying the mechanisms that regulate intrinsic neuronal regeneration capacity following axotomy. These studies frequently need to indicate the regenerative status of the corresponding neurons. We summarize the critical issues regarding immunohistochemical detection of several regeneration‐associated proteins as markers for the initiation of the regeneration program in rat primary sensory neurons and indicators of axon regeneration in the peripheral nerves. This overview also includes our own results of GAP43 and SCG10 expression in different DRG neurons following double immunostaining with molecular markers of neuronal subpopulations (NF200, CGRP, and IB4) as well as transcription factors (ATF3 and activated STAT3) following unilateral sciatic nerve injury. Anat Rec, 301:1618–1627, 2018. © 2018 Wiley Periodicals, Inc.
Activity patterns of insectivorous bats and birds in northern Scandinavia (69° N), during continuous midsummer daylight

Previous studies suggest that many species of insectivorous bats are nocturnal, despite the relatively low availability of their insect prey at night, because of the risk of predation by diurnal predatory birds. We hypothesised that if this was the case bats living above the arctic circle would alter their feeding behaviour during midsummer because there would no longer be any benefit to restricting their activity to the period when their prey are least abundant. Alternatively, if bats were more influenced by competition from aerial insectivorous birds they would continue to feed at ‘night’ to avoid such competition. In northern Norway (69° N), during continuous midsummer daylight, insectivorous sand martins (Riparia riparia) concentrated their aerial feeding activity when aerial insects were most abundant. The birds stopped feeding between 23:00 and 07:00 when aerial insects were least abundant. In contrast, northern bats (Eptesicus nilssonii), fed mostly between 22:00 and 02:00, coinciding with the lowest aerial insect availability, and with the period when light levels were lowest (ca 1000 lux). Bat activity patterns were closest to those predicted by the avian competition hypothesis. The low densities of both sand martins and Northern bats in the study area, however, were less consistent with this hypothesis. Possibly populations of both species were higher historically and the observed patterns reflected historical competition. Bat activity was most closely correlated to ambient light levels. This raised two alternative explanations that we could not eliminate. Perhaps there was differential predation risk, between the brightest and darkest parts of the day, because the visual capacities of falcons are strongly dependent on luminance. Alternatively the bats may have been entrained to emerge at given light levels by their behaviour at other times of year.
LOW MASSES AND HIGH REDSHIFTS: THE EVOLUTION OF THE MASS–METALLICITY RELATION

We present the first robust measurement of the high redshift mass–metallicity (MZ) relation at 108 ≲ M/M☉ ≲ 1010, obtained by stacking spectra of 83 emission-line galaxies with secure redshifts between 1.3 ≲ z ≲ 2.3. For these redshifts, infrared grism spectroscopy with the Hubble Space Telescope Wide Field Camera 3 is sensitive to the R23 metallicity diagnostic: ([O ii] λλ3726, 3729 + [O iii] λλ4959, 5007)/Hβ. Using spectra stacked in four mass quartiles, we find a MZ relation that declines significantly with decreasing mass, extending from 12+log(O/H) = 8.8 at M = 109.8 M☉, to 12+log(O/H) = 8.2 at M = 108.2M☉. After correcting for systematic offsets between metallicity indicators, we compare our MZ relation to measurements from the stacked spectra of galaxies with M ≳ 109.5M☉ and z ∼ 2.3. Within the statistical uncertainties, our MZ relation agrees with the z ∼ 2.3 result, particularly since our somewhat higher metallicities (by around 0.1 dex) are qualitatively consistent with the lower mean redshift (z = 1.76) of our sample. For the masses probed by our data, the MZ relation shows a steep slope which is suggestive of feedback from energy-driven winds, and a cosmological downsizing evolution where high mass galaxies reach the local MZ relation at earlier times. In addition, we show that our sample falls on an extrapolation of the star-forming main sequence (the SFR–M* relation) at this redshift. This result indicates that grism emission-line selected samples do not have preferentially high star formation rates (SFRs). Finally, we report no evidence for evolution of the mass-metallicity-SFR plane; our stack-averaged measurements show excellent agreement with the local relation.
Use of Dried Capillary Blood Sampling for Islet Autoantibody Screening in Relatives: A Feasibility Study.

BACKGROUND Islet autoantibody testing provides the basis for assessment of risk of progression to type 1 diabetes. We set out to determine the feasibility and acceptability of dried capillary blood spot-based screening to identify islet autoantibody-positive relatives potentially eligible for inclusion in prevention trials. MATERIALS AND METHODS Dried blood spot (DBS) and venous samples were collected from 229 relatives participating in the TrialNet Pathway to Prevention Study. Both samples were tested for glutamic acid decarboxylase, islet antigen 2, and zinc transporter 8 autoantibodies, and venous samples were additionally tested for insulin autoantibodies and islet cell antibodies. We defined multiple autoantibody positive as two or more autoantibodies in venous serum and DBS screen positive if one or more autoantibodies were detected. Participant questionnaires compared the sample collection methods. RESULTS Of 44 relatives who were multiple autoantibody positive in venous samples, 42 (95.5%) were DBS screen positive, and DBS accurately detected 145 of 147 autoantibody-negative relatives (98.6%). Capillary blood sampling was perceived as more painful than venous blood draw, but 60% of participants would prefer initial screening using home fingerstick with clinic visits only required if autoantibodies were found. CONCLUSIONS Capillary blood sampling could facilitate screening for type 1 diabetes prevention studies.