Miracle-dz/UniFAR-FTUs huggingface dataset:
Patterns of disclosure and antiretroviral treatment adherence in a South African mining workplace programme and implications for HIV prevention

Social and psychological barriers to the disclosure of one's seropositive HIV status to significant others and poor adherence to taking medications pose significant challenges to the scaling-up of access to antiretroviral treatment (ART) in the workplace. Such barriers are predictive of sub-optimal treatment outcomes and bedevil HIV-prevention interventions at a societal level. Against this background, this article explores the lived experiences of 19 HIV-positive male participants, between the ages of 33 and 57 years, who were enrolled in an ART programme managed at an occupational health clinic at a mining company in South Africa. The majority of these mineworkers had been aware of their HIV status for between 5 and 7 years. The study explored psychological and relational factors, as aspects of these participants lived experiences, which had a bearing on their adherence to their ART regimen and the disclosure choices that they made regarding their HIV status. In our sample, those participants who were adherent demonstrated higher levels of control and acceptance of their HIV infection and were more confident in their ability to manage their treatment, while the group who were non-adherent presented with lower levels of adherence motivation and self-efficacy, difficulties in maintaining a healthy lifestyle and significant challenges in maintaining control over their lives. While most of the men favoured disclosing their HIV status to their partners for the sake of treatment support, they were less sure about disclosing to family members and non-family members, respectively, because of their need to protect these persons and due to their fear of being stigmatised. It was evident that treatment adherence choices and behaviours were impacted by psychological and relational factors, including disclosure decisions. We conclude with a bivariate model for understanding the adherence behaviours that influenced different patterns of ART adherence among the sample, and offer recommendations for HIV-prevention and treatment interventions in a mining workplace.
Understanding and predicting effort in software projects

We set out to answer a question we were asked by software project management: how much effort remains to be spent on a specific software project and how will that effort be distributed over time? To answer this question we propose a model based on the concept that each modification to software may cause repairs at some later time and investigate its theoretical properties and application to several projects in Avaya to predict and plan development resource allocation. Our model presents a novel unified framework to investigate and predict effort, schedule, and defects of a software project. The results of applying the model confirm a fundamental relationship between the new feature and defect repair changes and demonstrate its predictive properties.
Memory Extinction Entails the Inhibition of the Transcription Factor NF-κB

In contextual memories, an association between a positive or negative reinforcement and the contextual cues where the reinforcement occurs is formed. The re-exposure to the context without reinforcement can lead to memory extinction or reconsolidation, depending on the number of events or duration of a single event of context re-exposure. Extinction involves the temporary waning of the previously acquired conditioned response. The molecular processes underlying extinction and the mechanisms which determine if memory will reconsolidate or extinguish after retrieval are not well characterized, particularly the role of transcription factors and gene expression. Here we studied the participation of a transcription factor, NF-κB, in memory extinction. In the crab context-signal memory, the activation of NF-κB plays a critical role in consolidation and reconsolidation, memory processes that are well characterized in this model. The administration of a NF-κB inhibitor, sulfasalazine prior to extinction session impeded spontaneous recovery. Moreover, reinstatement experiments showed that the original memory was not affected and that NF-κB inhibition by sulfasalazine impaired spontaneous recovery strengthening the ongoing memory extinction process. Interestingly, in animals with fully consolidated memory, a brief re-exposure to the training context induced neuronal NF-κB activation and reconsolidation, while prolonged re-exposure induced NF-κB inhibition and memory extinction. These data constitutes a novel insight into the molecular mechanisms involved in the switch between memory reconsolidation and extinction. Moreover, we propose the inhibition of NF-κB as the engaged mechanism underlying extinction, supporting a novel approach for the pharmacological enhancement of this memory process. The accurate description of the molecular mechanisms that support memory extinction is potentially useful for developing new strategies and drug candidates for therapeutic treatments of the maladaptive memory disorders such as post-traumatic stress, phobias, and drug addiction.
Bacterial Community Analysis of Drinking Water Biofilms in Southern Sweden

Next-generation sequencing of the V1–V2 and V3 variable regions of the 16S rRNA gene generated a total of 674,116 reads that described six distinct bacterial biofilm communities from both water meters and pipes. A high degree of reproducibility was demonstrated for the experimental and analytical work-flow by analyzing the communities present in parallel water meters, the rare occurrence of biological replicates within a working drinking water distribution system. The communities observed in water meters from households that did not complain about their drinking water were defined by sequences representing Proteobacteria (82–87%), with 22–40% of all sequences being classified as Sphingomonadaceae. However, a water meter biofilm community from a household with consumer reports of red water and flowing water containing elevated levels of iron and manganese had fewer sequences representing Proteobacteria (44%); only 0.6% of all sequences were classified as Sphingomonadaceae; and, in contrast to the other water meter communities, markedly more sequences represented Nitrospira and Pedomicrobium. The biofilm communities in pipes were distinct from those in water meters, and contained sequences that were identified as Mycobacterium, Nocardia, Desulfovibrio, and Sulfuricurvum. The approach employed in the present study resolved the bacterial diversity present in these biofilm communities as well as the differences that occurred in biofilms within a single distribution system, and suggests that next-generation sequencing of 16S rRNA amplicons can show changes in bacterial biofilm communities associated with different water qualities.
Foraging in Semantic Fields: How We Search Through Memory

When searching for concepts in memory--as in the verbal fluency task of naming all the animals one can think of--people appear to explore internal mental representations in much the same way that animals forage in physical space: searching locally within patches of information before transitioning globally between patches. However, the definition of the patches being searched in mental space is not well specified. Do we search by activating explicit predefined categories (e.g., pets) and recall items from within that category (categorical search), or do we activate and recall a connected sequence of individual items without using categorical information, with each item recalled leading to the retrieval of an associated item in a stream (associative search), or both? Using semantic representations in a search of associative memory framework and data from the animal fluency task, we tested competing hypotheses based on associative and categorical search models. Associative, but not categorical, patch transitions took longer to make than position-matched productions, suggesting that categorical transitions were not true transitions. There was also clear evidence of associative search even within categorical patch boundaries. Furthermore, most individuals' behavior was best explained by an associative search model without the addition of categorical information. Thus, our results support a search process that does not use categorical information, but for which patch boundaries shift with each recall and local search is well described by a random walk in semantic space, with switches to new regions of the semantic space when the current region is depleted.
Elecsys insulin assay: free insulin determination and the absence of cross-reactivity with insulin lispro.

Insulin assays are used in the identification of rare hypoglycemic syndromes, and may be useful in classifying the different types of diabetes (1)(2)(3). Hemolysis (4)(5)(6) and circulating anti-insulin antibodies (7)(8) are sources of interference in insulin determinations. Anti-insulin antibodies may be present in the serum of insulin-treated diabetic patients, even when they are treated with biosynthetic human insulin, and may also be found in the serum of type 1 diabetic patients before insulin administration. These antibodies interfere in competitive and noncompetitive insulin immunoassays. In the increasingly used two-site noncompetitive assays, anti-insulin antibodies may yield increased results. Thus, anti-insulin antibodies must be eliminated, usually through precipitation with polyethylene glycol, before the concentration of free (active) insulin is determined (9). In addition to these considerations, both biosynthetic human insulin and insulin lispro, a fully potent analog with a faster absorption rate, are used therapeutically so that not only human endogenous and exogenous insulin, but also insulin lispro may be present in samples in which the insulin assay is to be used. In the present study we performed a preliminary evaluation of an insulin electrochemiluminescence immunoassay recently developed by Roche Diagnostics (Mannheim, Germany) for the Elecsys® analyzer. We studied the analytical performance of this new insulin assay and assessed the results of insulin measurements in serum samples with and without anti-insulin antibodies. The Elecsys assay uses an 18-min incubation time and a 20-μL sample volume, and has a stated dynamic range of 0.2–1000 mIU/L (1.39–6945 pmol/L). Assays were performed on the Elecsys 2010 analyzer in singleton, according to the manufacturer’s instructions, with two different lot numbers. The Elecsys results were compared with those of our routine method (Bi-Insulin IRMA; Bio-Rad) in EDTA-plasma samples from 110 diabetic patients treated with oral hypoglycemic drugs …
Effect of Tibiotalar Joint Arthrodesis on Adjacent Tarsal Joint Pressure in a Cadaver Model

Background: Tibiotalar arthrodesis is the most common treatment of end-stage symptomatic ankle arthritis, but concerns exist about late findings of adjacent tarsal joint osteoarthritis. The purpose of this study was to evaluate the changes of pressure in the talonavicular, subtalar, and calcaneocuboid joints before and after rigid tibiotalar joint immobilization and at different levels of tibiopedal dorsiflexion. Methods: Twelve cadaver foot specimens were cyclically loaded on a servohydraulic test frame to 700 N. Joint contact pressure, peak pressure, and contact area in the three tarsal joints were measured before and after tibiotalar joint immobilization with three 6.5-mm screws to simulate ankle arthrodesis. Measurements were obtained at tibiopedal dorsiflexion angles of 0, 10, 20, and 30 degrees in normal ankle joints and at dorsiflexion angles of 0, 10, and 20 degrees in fixed tibiotalar joints. Paired Student's t-tests and one-way ANOVA with repeated measures were used to analyze the data. Results: Joint contact pressures did not show any statistically significant difference for the talonavicular and calcaneocuboid joints in the intact ankle. Contact pressures in the talonavicular and calcaneocuboid joints showed significant differences between 0 and 10 degrees and between 0 and 20 degrees of dorsiflexion (p < 0.05) in the fused ankle specimens. Comparison of the contact pressure of the talonavicular and the calcaneocuboid joints between the intact and the fused ankle specimens showed a significant difference at 10 and 20 degrees of dorsiflexion (p < 0.05). Subtalar joint contact pressure in the intact ankle showed a significant difference between 0 and 30 degrees of dorsiflexion (p < 0.05). Conclusions: These changes in joint pressures and contact area are consistent with findings of transverse tarsal joint arthritis seen in clinical studies. The current findings suggest that a substantial pressure increase in the talonavicular and calcaneocuboid joints at tibiopedal dorsiflexion levels simulating a late stance phase of the gait cycle may be responsible for the secondary tarsal joint degeneration occurring in late ankle arthrodesis.
Programming models and HW-SW interfaces abstraction for multi-processor SoC

For the design of classic computers the parallel programming concept is used to abstract HW/SW interfaces during high level specification of application software. The software is then adapted to existing multiprocessor platforms using a low level software layer that implements the programming model. Unlike classic computers, the design of heterogeneous MPSoC includes also building the processors and other kind of hardware components required to execute the software. In this case, the programming model hides both hardware and software refinements. This paper deals with parallel programming models to abstract both hardware and software interfaces in the case of heterogeneous MPSoC design. Different abstraction levels are needed. For the long term, the use of higher level programming models open new vistas for optimization and architecture exploration like CPU/RTOS tradeoffs
OpenSIUC Working Papers Political Networks Paper Archive Winter 2012 Gender , Social Networks , and Voting Behavior

This paper examines how interpersonal social networks help explain the voting behavior of men and women. We argue that the gender gap in voting is influenced by the partisan and gender composition of networks, rather than just the latter. Building on this foundation, we explain how gendering in network construction and impact helps create a cleavage between men and women even under conditions that are often close to "random mixing. " Analysis of the 2000 American National Election Study shows the voting gap is related to men excluding women from political networks, men being less exposed to females who support Democrats, and men being more strongly influence by women who support Republicans. The principal conclusion of the paper is that the role of social networks in explaining gendered voting is a function of combined partisan and gender segregation, principally by men. 1 There appear to be three ways in which social relations contribute to the maintenance of political differences. First…it is necessary to have a social basis for a political interest. It would be difficult in contemporary America, for example, to maintain voting differences by sex, because there are few policy issues persisting over a period of time that affect men and women differently. … Second, a necessary condition for the persistence of political differences is their transmission to succeeding generations. … Finally, given the origin of a voting difference in one generation and the transmittibility of it to the next, another condition is necessary…[m]embers of the social groups involved must be substantially more in contact with one another, socially and physically, than they are with opposing groups. This epigraph from Voting is a definitive statement on how social cleavages become politically significant. Although very few scholars directly challenge the Columbia researchers' theoretical claims, their example of " voting differences by sex " is striking in light of the gender voting gap that emerged in the last three decades of 1986). There is evidence that gender differences exist on policy (e.g., Box-Steffensmeier, et al. 2004) and that there is intergenerational socialization (e.g, Jenkins n.d.), satisfying two of the theoretical conditions for a political condition. However, the evidence suggesting that men and women have socially segregated interactions-that there is "a social basis for a political interest"-is less clear. There is some social segregation between men and women in social institutions, particularly as it pertains to politics (Burns et al. Walsh 2004) and in specific …
Missing Women and India’s Religious Demography

This article explores the relationship between religion, caste, infant mortality and fertility across Hindus and Muslims in India using recent data from the 2006 National Family Health Survey. The analysis shows that Muslims exhibit lower infant mortality rates relative to Hindus, and that this difference is not adequately explained by socio-economic status, location and policy variables. We argue that the combination of gender preference and heterogeneity in desired fertility across religious groups offers one potential explanation for the observed differences in mortality rates. Our data support this view; the difference in infant mortality between Muslims and Hindus is concentrated at higher birth order and among girls, irrespective of their birth order. We also show that there are differences in mortality between lower-caste Hindus and higher caste Hindus in our sample.
Fracture Toughness of Polypropylene-Based Particulate Composites

The fracture behaviour of polymers is strongly affected by the addition of rigid particles. Several features of the particles have a decisive influence on the values of the fracture toughness: shape and size, chemical nature, surface nature, concentration by volume, and orientation. Among those of thermoplastic matrix, polypropylene (PP) composites are the most industrially employed for many different application fields. Here, a review on the fracture behaviour of PP-based particulate composites is carried out, considering the basic topics and experimental techniques of Fracture Mechanics, the mechanisms of deformation and fracture, and values of fracture toughness for different PP composites prepared with different particle scale size, either micrometric or nanometric.
The Divergent Development of the Apical Ectodermal Ridge in the Marsupial Monodelphis domestica

Marsupials give birth after short gestation times to neonates that have an intriguing combination of precocial and altricial features, based on their functional necessity after birth. Perhaps most noticeably, marsupial newborns have highly developed forelimbs, which provide the propulsion necessary for the newborn's crawl to the teat. To achieve their advanced state at birth, the development of marsupial forelimbs is accelerated. The development of the newborn's hind limb, which plays no part in the crawl, is not accelerated, and is likely even delayed. Given the large differences in the rate of limb outgrowth among marsupials and placentals, we hypothesize that the pathways underlying the early development and outgrowth of marsupial limbs, especially that of their forelimbs, will also be divergent. As a first step toward testing this, we examine the development of one of the two major signaling centers of the developing limb, the apical ectodermal ridge (AER), in a marsupial, Monodelphis domestica. We found that, while both opossum limbs have reduced physical AER's, in the opossum forelimb this reduction has been taken to the extreme. Where the M. domestica forelimb should have an AER, it instead has only a few patches of disorganized cells. These results make the marsupial, M. domestica, the only known amniote (without reduced limbs) to exhibit no morphological AER. However, both M. domestica limbs normally express Fgf8, a molecular marker of the AER. Anat Rec 293:1325–1332, 2010. © 2010 Wiley‐Liss, Inc.
Demyelination, Astrogliosis, and Accumulation of Ubiquitinated Proteins, Hallmarks of CNS Disease in hsf1-Deficient Mice

The heat shock transcription factors (Hsfs) are responsible for the heat shock response, an evolutionarily conserved process for clearance of damaged and aggregated proteins. In organisms such as Caenorhabditis elegans, which contain a single Hsf, reduction in the level of Hsf is associated with the appearance of age-related phenotypes and increased accumulation of protein aggregates. Mammalian cells express three hsfs (hsf1, hsf2, hsf4) and their role in CNS homeostasis remains unclear. In this study, we examined the effects of deletion of single or multiple hsf genes in the CNS using mutant mice. Our results show that hsf1−/− mice display progressive myelin loss that accompanies severe astrogliosis and this is exacerbated in the absence of either the hsf2 or hsf4 gene. Magnetic resonance imaging and behavioral studies indicate reduction in the white matter tracts of the corpus callosum, and deficiencies in motor activity, respectively, in aged hsf1−/− mice. Concomitantly, hsf1−/− aged CNS exhibit increased activated microglia and apoptotic cells that are mainly positive for GFAP, an astrocyte-specific marker. Studies based on the expression of short-lived ubiquitinated green fluorescent protein (GFPu) in living hsf1−/− cells indicate that they exhibit reduced ability to degrade ubiquitinated proteins, accumulate short-lived GFPu, and accumulate aggregates of the Huntington's model of GFP containing trinucleotide repeats (Q103-GFP). Likewise, hsf1−/− brain and astrocytes exhibit higher than wild-type levels of ubiquitinated proteins, increased levels of protein oxidation, and increased sensitivity to oxidative stress. These studies indicate a critical role for mammalian hsf genes, but specifically hsf1, in the quality control mechanisms and maintenance of CNS homeostasis during the organism's lifetime.
Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma

Genetic variation of the antigen processing machinery (APM) components TAP2, LMP7, and ERAP1 is related to cervical carcinoma risk, although the relation with expression and clinical outcome remains unknown. We have investigated the occurrence of APM component single nucleotide polymorphisms (SNPs) in cervical carcinoma. Twelve nonsynonymous, coding SNPs in the TAP1, TAP2, LMP2, LMP7, and ERAP1 genes were genotyped in 75 cervical carcinoma patients with known APM component and HLA class I expression levels. Individual genotype distributions were assessed for association with APM component expression, various histopathological parameters and survival. Genotype distributions at the ERAP1‐56 and ERAP1‐127 loci were significantly associated with overall survival (OS); haplotype construction spanning these two SNPs revealed that the combination of a major allele at ERAP1‐56 and a minor allele at ERAP1‐127 was significantly associated with survival, homozygosity for this haplotype being associated with decreased OS (5‐year survival 50% vs. 70 and 81% for complete absence or heterozygosity for this haplotype, respectively; P = 0.021). Heterozygosity for this haplotype was an independent predictor for better OS in multivariate analysis (HR = 0.219; P = 0.014). These data indicate that genetic variation in APM component genes, particularly ERAP1, is an important contributing factor in cervical carcinogenesis, progressive tumor growth and survival. The location of the ERAP1‐127 SNP in the peptidase M1 domain of the ERAP1 aminopeptidase suggests the possibility of direct functional consequences of variation at this locus. © 2009 Wiley‐Liss, Inc.
An example of localized D-branes solution on PP-wave backgrounds

In this note we provide an explicit example of type-IIB supersymmetric D3-branes solution on a pp-wave like background, consisting in the product of an eight-dimensional pp-wave times a two-dimensional flat space. An interesting property of our solution is the fully localization of the D3-branes (i.e. the solution depends on all the transverse coordinates). Then we show the generalization to other Dp-branes and to the D1/D5 system.