Miracle-dz/UniFAR-FTUs huggingface dataset:
Heritability and Genetic Parameters Estimated for Fruits Size in F1 Interspecific Apple Hybrids

Interspecific hybridization is a frequently used b reeding method to create a wide genetic diversity useful to broaden selection base and creating new cultivars of apple. The aim of the present study was to determine the heritability of fruit size in F 1 apple hybrids belonging to interspecific apple pollenization between different cultivars and wild species (rustic apple crabs) li ke Malus coronaria, M. floribunda, M. niedzwetzkyana, M. zumi, and M. prunifolia . A wide variability of fruits sizes has been identified, in all families b eing identified a broad fruit size variability (e.g . CV = 47.1% in M. zumi ◊ 'Golden Delicious', CV = 42.2% in M. coronaria ◊ 'Jonathan' and 'Rosu de Cluj' ◊ M. prunifolia ). Between the five cyclic hybridizations, the mean of notes for fruit size was quite close, with limits ranging from 2.70, from hybridis ation where the species M. floribunda and M. prunifolia participated as paternal testers, and 2.93, in the cyclic where specie M. niedzwetzkyana was hybridization as paternal tester (less than "3", wh ich express "small fruits", by 1-9 scale). Even if the trait studied showed a strong genetic determinism ( H 2 : 0.611-0.700), analysis of the heritability coefficients in narrow sense (h 2 between 0.074 when M. prunifolia was used as paternal tester and 0.154 when M. floribunda was used as paternal tester) revealed that not add itive effects played the most important role, but non-additive effects, of d ominance and epistatic. Genetic gain and expected selection response had similar values, which have s hown that the chances of obtaining by selection a population of hybrids that have the desired fruit s ize are greater when in interspecific hybridization are involved as genitors M. zumi and M. floribunda , compared to M. niedzwetzkyana and M. prunifolia .
Storage Rates of Circulating Free Fatty Acid Into Adipose Tissue During Eating or Walking in Humans

We measured subcutaneous adipose tissue free fatty acid (FFA) storage rates in postprandial and walking conditions to better understand the contributions of this pathway to body fat distribution. Palmitate tracers were infused intravenously and fat biopsies collected to measure palmitate storage in upper- (UBSQ) and lower-body subcutaneous (LBSQ) fat in 41 (17 men) and 40 (16 men) volunteers under postprandial and under postabsorptive walking conditions, respectively. Postprandial palmitate storage was greater in women than men in UBSQ (0.50 ± 0.25 vs. 0.33 ± 0.37 μmol ⋅ kg fat−1 ⋅ min−1; P = 0.007) and LBSQ fat (0.37 ± 0.25 vs. 0.22 ± 0.20 μmol ⋅ kg fat−1 ⋅ min−1; P = 0.005); storage rates were significantly greater in UBSQ than LBSQ fat in both sexes. During walking, UBSQ palmitate storage did not differ between sexes, whereas LBSQ storage was greater in women than men (0.40 ± 0.22 vs. 0.25 ± 0.15 μmol ⋅ kg fat−1 ⋅ min−1; P = 0.01). In women only, walking palmitate storage was significantly greater in LBSQ than UBSQ fat. Adipocyte CD36 and diacylglycerol acyltransferase (DGAT) correlated with LBSQ palmitate storage in the postprandial and walking condition, respectively. We conclude that UBSQ fat is the preferred postprandial FFA storage depot for both sexes, whereas walking favors storage in LBSQ fat in women. Transmembrane transport (CD36) and esterification into triglycerides (DGAT) may be rate-limiting steps for LBSQ FFA storage during feeding and exercise.
I can’t take my eyes off of it : Attention attraction effects of implementation intentions

Implementation intentions (“If situation X is encountered, I will perform behavior Y”) have been shown to improve goal attainment, relative to mere goal intentions, through automating action control. So far, they have only been examined with regard to three features of automaticity without testing the uncontrollability of implementation intention effects. In two studies on the impact of implementation intentions on visual attention, support was found for the uncontrollability of their effects. Implementation intentions attracted attention (i.e., a situational cue X disrupted attention from a focal task) even during the pursuit of different goals, more than goal intentions. In addition, the regulation of the action control through implementation intentions in response to these attention attraction effects was examined in a subsequent task. Improved performance co–occurred with attention attraction, indicating that no disengagement from the implementation intention took place. Implications for the applicati.
Bacillus subtilis Class Ib Ribonucleotide Reductase: High Activity and Dynamic Subunit Interactions

The class Ib ribonucleotide reductase (RNR) isolated from Bacillus subtilis was recently purified as a 1:1 ratio of NrdE (α) and NrdF (β) subunits and determined to have a dimanganic-tyrosyl radical (MnIII2-Y·) cofactor. The activity of this RNR and the one reconstituted from recombinantly expressed NrdE and reconstituted MnIII2-Y· NrdF using dithiothreitol as the reductant, however, was low (160 nmol min–1 mg–1). The apparent tight affinity between the two subunits, distinct from all class Ia RNRs, suggested that B. subtilis RNR might be the protein that yields to the elusive X-ray crystallographic characterization of an “active” RNR complex. We now report our efforts to optimize the activity of B. subtilis RNR by (1) isolation of NrdF with a homogeneous cofactor, and (2) identification and purification of the endogenous reductant(s). Goal one was achieved using anion exchange chromatography to separate apo-/mismetalated-NrdFs from MnIII2-Y· NrdF, yielding enzyme containing 4 Mn and 1 Y·/β2. Goal two was achieved by cloning, expressing, and purifying TrxA (thioredoxin), YosR (a glutaredoxin-like thioredoxin), and TrxB (thioredoxin reductase). The success of both goals increased the specific activity to ∼1250 nmol min–1 mg–1 using a 1:1 mixture of NrdE:MnIII2-Y· NrdF and either TrxA or YosR and TrxB. The quaternary structures of NrdE, NrdF, and NrdE:NrdF (1:1) were characterized by size exclusion chromatography and analytical ultracentrifugation. At physiological concentrations (∼1 μM), NrdE is a monomer (α) and MnIII2-Y· NrdF is a dimer (β2). A 1:1 mixture of NrdE:NrdF, however, is composed of a complex mixture of structures in contrast to expectations.
“I Wish that I Belonged More in this Whole Engineering Group:” Achieving Individual Diversity

Engineers need a breadth of experience to enrich the gene pool of ideas from which elegant engineering solutions can be drawn, called “individual diversity. ” While performing large ethnographic research studies where hundreds of engineering students were interviewed, we interviewed Inez, a student that epitomizes individual diversity. Inez is unlike most engineers: she is female, multi‐minority, and from a socio‐economically disadvantaged background. Inez's story is told here using “ethnography of the particular,” where the story of a single individual is explored. Inez has persevered through challenges posed by her lack of familiarity with the culture of engineering, her weak high school preparation, and her feelings of being an outsider in engineering. Inez's story demonstrates that the playing field in engineering is still not level, particularly for socio‐economically disadvantaged students. Her story provides a poignant example of the impact of five of Conefrey's cultural myths of science.
First-Trimester Maternal Serum a Disintegrin and Metalloprotease 12 (ADAM12) and Adverse Pregnancy Outcome

OBJECTIVE: To examine the possible association of maternal serum a disintegrin and metalloprotease (ADAM12) in the first trimester of pregnancy and subsequent development of preeclampsia, delivery of small for gestational age (SGA) neonates, and spontaneous preterm delivery. METHODS: The maternal serum concentration of ADAM12 at 11 0/7 to 13 6/7 weeks was measured in 128 cases of preeclampsia, 88 cases of gestational hypertension, 296 cases with SGA neonates, 58 cases of spontaneous preterm delivery, and 570 controls. Regression analysis was used to determine which of the maternal factors and fetal crown rump length were significant predictors of ADAM12 in the control group, and from the regression model the value in each case and control was expressed as a multiple of median (MoM). The levels of ADAM12 MoM were compared in cases and controls. RESULTS: In the control group the concentration of ADAM12 increased with fetal crown rump length, decreased with maternal weight and was higher in African-American than in white women. There was a significant association between ADAM12 and pregnancy-associated plasma protein A (r=0.417, P<.001) and between each metabolite and birth weight percentile (r=0.176, P<.001 and r=0.109, P=.009). In the SGA group, the median ADAM12 concentration (0.848 MoM) was lower (P<.001), but in pregnancies complicated by preeclampsia (0.954 MoM), gestational hypertension (1.013 MoM), and spontaneous preterm delivery (1.048 MoM) the levels were not significantly different from controls (1.011 MoM). CONCLUSION: There is a good correlation between the maternal serum ADAM12 and pregnancy-associated plasma protein A concentration. Measurement of ADAM12 does not provide useful prediction of SGA, preeclampsia, or spontaneous preterm delivery. LEVEL OF EVIDENCE: II
Regulatory Effects of Caffeic Acid Phenethyl Ester on Neuroinflammation in Microglial Cells

Microglial activation has been widely demonstrated to mediate inflammatory processes that are crucial in several neurodegenerative disorders. Pharmaceuticals that can deliver direct inhibitory effects on microglia are therefore considered as a potential strategy to counter balance neurodegenerative progression. Caffeic acid phenethyl ester (CAPE), a natural phenol in honeybee propolis, is known to possess antioxidant, anti-inflammatory and anti-microbial properties. Accordingly, the current study intended to probe the effects of CAPE on microglia activation by using in vitro and in vivo models. Western blot and Griess reaction assay revealed CAPE significantly inhibited the expressions of inducible nitric oxide synthase (NOS), cyclooxygenase (COX)-2 and the production of nitric oxide (NO). Administration of CAPE resulted in increased expressions of hemeoxygenase (HO)-1and erythropoietin (EPO) in microglia. The phosphorylated adenosine monophosphate-activated protein kinase (AMPK)-α was further found to regulate the anti-inflammatory effects of caffeic acid. In vivo results from immunohistochemistry along with rotarod test also revealed the anti-neuroinflammatory effects of CAPE in microglia activation. The current study has evidenced several possible molecular determinants, AMPKα, EPO, and HO-1, in mediating anti-neuroinflammatory responses in microglial cells.
The Cytological Events and Molecular Control of Life Cycle Development of Trypanosoma brucei in the Mammalian Bloodstream

African trypanosomes cause devastating disease in sub-Saharan Africa in humans and livestock. The parasite lives extracellularly within the bloodstream of mammalian hosts and is transmitted by blood-feeding tsetse flies. In the blood, trypanosomes exhibit two developmental forms: the slender form and the stumpy form. The slender form proliferates in the bloodstream, establishes the parasite numbers and avoids host immunity through antigenic variation. The stumpy form, in contrast, is non-proliferative and is adapted for transmission. Here, we overview the features of slender and stumpy form parasites in terms of their cytological and molecular characteristics and discuss how these contribute to their distinct biological functions. Thereafter, we describe the technical developments that have enabled recent discoveries that uncover how the slender to stumpy transition is enacted in molecular terms. Finally, we highlight new understanding of how control of the balance between slender and stumpy form parasites interfaces with other components of the infection dynamic of trypanosomes in their mammalian hosts. This interplay between the host environment and the parasite’s developmental biology may expose new vulnerabilities to therapeutic attack or reveal where drug control may be thwarted by the biological complexity of the parasite’s lifestyle.
A 2-tuple fuzzy linguistic representation model for computing with words

The fuzzy linguistic approach has been applied successfully to many problems. However, there is a limitation of this approach imposed by its information representation model and the computation methods used when fusion processes are performed on linguistic values. This limitation is the loss of information; this loss of information implies a lack of precision in the final results from the fusion of linguistic information. In this paper, we present tools for overcoming this limitation. The linguistic information is expressed by means of 2-tuples, which are composed of a linguistic term and a numeric value assessed in (-0.5, 0.5). This model allows a continuous representation of the linguistic information on its domain, therefore, it can represent any counting of information obtained in a aggregation process. We then develop a computational technique for computing with words without any loss of information. Finally, different classical aggregation operators are extended to deal with the 2-tuple linguistic model.
Subclassifying chronic fatigue syndrome through exercise testing.

PURPOSE The purpose of this study was to examine physiological responses of persons with chronic fatigue syndrome (CFS) to a graded exercise test. METHODS Cardiopulmonary exercise tests were performed on 189 patients diagnosed with CFS. Based on values for peak oxygen consumption, patients were assigned to one of four impairment categories (none, mild, moderate, and severe), using American Medical Association (AMA) guidelines. A one-way MANOVA was used to determine differences between impairment categories for the dependent variables of age, body mass index, percentage of predicted [OV0312]O(2), resting and peak heart rates, resting and peak systolic blood pressure, respiratory quotient (RQ), and rating of perceived exertion. RESULTS Significant differences were found between each impairment level for percentage of predicted [OV0312]O(2) and peak heart rate. Peak systolic blood pressure values for the "moderate," and "severe" groups differed significantly from each other and both other groups. The more impaired groups had lower values. The no impairment group had a significantly higher peak RQ than each of the other impairment levels (all P < 0.001). Peak [OV0312]O(2) values were less than predicted for all groups. Compared with the males, the women achieved actual values for peak [OV0312]O(2) that were closer to their predicted values. CONCLUSION Despite a common diagnosis, the functional capacity of CFS patients varies greatly. Stratifying patients by function allows for a more meaningful interpretation of the responses to exercise and may enable differential diagnosis between subsets of CFS patients.
A Gramian-based approach to model reduction for uncertain systems

The paper considers the problem of model reduction for a class of uncertain systems with structured norm bounded uncertainty. The paper introduces controllability and observability Gramians in terms of certain parameterized algebraic Riccati inequalities. This enables a balanced truncation model reduction procedure for uncertain systems to be presented. Error bounds for this model reduction procedure are derived. The paper also investigates Hinfin model reduction for uncertain systems. The solution to this problem is shown to involve constructing the underlying Gramians satisfying a certain rank constraint.
Regulating expressions of cyclin D1, pRb, and anti-cancer effects of deguelin on human Burkitt's lymphoma Daudi cells in vitro

AbstractAim:To investigate anticancer effects and molecular mechanism of deguelin on human Burkitt's lymphoma Daudi cells in vitro and compare the cytotoxicities of deguelin on Daudi cells and human peripheral blood monocular cells (PBMC). Methods:The effects of deguelin on the growth of Daudi cells were studied by 3-(4, 5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium (MTT) assay. Apoptosis were dectected through Hoechst 33258 staining and Annexin V/PI double-labeled cytometry. The effect of deguelin on the cell cycle of Daudi cells were studied by a propidium iodide method. The expressions of cyclin D1 and pRb were checked by Western blot.Results:The proliferation of Daudi cells were decreased in deguelin-treated group with a 24-h IC50 value of 51.55 nmol/L. Deguelin induced Daudi cells apoptosis was in a time- and dose-dependent manner. G0/G1 phase increased and S phase decreased in Daudi cells treated with deguelin. With deguelin 0, 5, 10, 20, and 40 nmol/L treatment for 24 h, G0/G1 phase increased from 37.34% to 56.56%, whereas S phase decreased from 37.72% to 21.36%. PBMC was less sensitive to the cytotoxic effect of deguelin than Daudi cells. The expression of cyclin D1 and pRb protein were decreased sharply in Daudi cells treated with deguelin.Conclusion:Deguelin is able to inhibit the proliferation of Daudi cells by regulating the cell cycle that arrested cells at G0/G1 phase and inducing the cell apoptosis. Moreover, deguelin selectively induced apoptosis of Daudi cells with low toxicity in PBMC. The antitumor effects of deguelin were related to down-regulating the expression of cyclin D1 and pRb protein.
CLINICAL USEFULNESS OF A HIGHLY SENSITIVE ENZYME‐IMMUNOASSAY OF TSH

Using a recently developed sensitive enzyme immunoassay (EIA) for TSH, serum TSH levels in normal subjects and patients with various thyroid disorders were measured. The minimum detectable concentration was less than 0.005 mU/l. An excellent correlation was observed between TSH values measured by EIA and by sensitive radioimmunoassay (r= 0.932). In 26 normal subjects, serum TSH ranged from 0.30 to 2‐65 mU/l (geometric mean 0.97 raU/l). In 27 untreated hyperthyroid Graves' patients, serum TSH was detected in all but one, ranging from 0.005 to 0.19 mU/l (geometric mean 0.040). These values were proved to be specific for human TSH by absorption, recovery, cross‐reactivity and dilution studies; non‐specific serum effects were also ruled out. In 10 patients with destructive thyroiditis, similar TSH values (0.005‐0.20 mU/l, mean 0.032) were observed. However, no significant correlations between TSH and circulating thyroid hormone levels were observed in these thyrotoxic conditions. Furthermore, 9 untreated Graves' patients did not respond to a single i.v. injection of TRH. In 13 hypothyroid patients with hypothalamopituitary disorders, 10 had basal TSH levels of less than 0.4 mU/l, and TRH tests in five gave peak TSH values of more than 0.8 mU/l, which were associated with significant increases in serum T3. In three patients with Sheehan's syndrome, elevated basal TSH levels were observed. Two of them responded to TRH, but these TSH elevations were not associated with T3 increases. In conclusion, this sensitive EIA could measure TSH levels in most patients with thyrotoxicosis and central hypothyroidism. However, the true significance of these measured values needs to be elucidated by future studies.
Does Gender Impact the Perception of Negative Information Related to Celebrity Endorsers?

The study examines the effectiveness of celebrity endorsements by examining how a respondent's gender impacts identification with a celebrity spokesperson and the processing of negative information about that celebrity's behavior. The authors found that negative information is harmful to both celebrities’ reputations and sponsors’ brands across a variety of effectiveness measures. Gender congruency between consumers and celebrities did impact attitudes, but was not found to interact with the processing of negative information. Implications for advertisers are addressed.
Images in Words: Presidential Rhetoric, Charisma, and Greatness

We analyzed two sets of U.S. presidents' speeches to determine whether their propensities to convey images in words were linked to perceptions of their charisma and greatness. As predicted, presidents who engaged in more image-based rhetoric in their inaugural addresses were rated higher in charisma (Study 1). Presidents who engaged in more image-based rhetoric in speeches that historians considered their most significant ones were rated higher in both charisma and greatness (Study 2). Together, these findings suggest that the successful articulation and enactment of a leader's vision may rest on his or her ability to paint followers a verbal picture of what can be accomplished with their help.
Learning to Label Aerial Images from Noisy Data

When training a system to label images, the amount of labeled training data tends to be a limiting factor. We consider the task of learning to label aerial images from existing maps. These provide abundant labels, but the labels are often incomplete and sometimes poorly registered. We propose two robust loss functions for dealing with these kinds of label noise and use the loss functions to train a deep neural network on two challenging aerial image datasets. The robust loss functions lead to big improvements in performance and our best system substantially outperforms the best published results on the task we consider.
Rights and the Common Good: The Communitarian Perspective. Amitai Etzioni.

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