Miracle-dz/UniFAR-FTUs huggingface dataset:
Event-centric search and exploration in document collections

Textual data ranging from corpora of digitized historic documents to large collections of news feeds provide a rich source for temporal and geographic information. Such types of information have recently gained a lot of interest in support of different search and exploration tasks, e.g., by organizing news along a timeline or placing the origin of documents on a map. However, for this, temporal and geographic information embedded in documents is often considered in isolation. We claim that through combining such information into (chronologically ordered) event-like features interesting and meaningful search and exploration tasks are possible. In this paper, we present a framework for the extraction, exploration, and visualization of event information in document collections. For this, one has to identify and combine temporal and geographic expressions from documents, thus enriching a document collection by a set of normalized events. Traditional search queries then can be enriched by conditions on the events relevant to the search subject. Most important for our event-centric approach is that a search result consists of a sequence of events relevant to the search terms and not just a document hit-list. Such events can originate from different documents and can be further explored, in particular events relevant to a search query can be ordered chronologically. We demonstrate the utility of our framework by different (multilingual) search and exploration scenarios using a Wikipedia corpus.
Nursing Students' Empowerment in Distance Education: Testing Kanter's Theory.

This qualitative, explanatory study examined Post-RN baccalaureate nursing students’ experiences of empowerment with distance education and computer conferencing (CC) for fit with the constructs of Kanter’s (1977, 1993) Theory of Structural Power in Organizations. Seven post-RNs from Canadian distance education nursing programs were interviewed. Interview transcripts were examined using content analysis. Kanter’s theory was useful in describing empowerment structures in distance education courses. Feedback from instructors, access to library facilities, and support from employers and family are essential elements of an empowering educational experience. Students missed face-to-face contact. Two themes unrelated to Kanter’s theory—self-direction and determination to succeed—emerged. This study, based on a theoretical framework, will be of interest to educators and administrators of distance education programs. Cette etude qualitative examine l’experience d’autonomisation d’etudiantes au baccalaureat en sciences infirmieres en education a distance et en conference telematique en fonction de la theorie de Kanter (1977, 1993), la theorie du pouvoir structurel dans les organisations. Sept etudiantes du programme de sciences infirmieres a distance ont etes interviewees. Les transcriptions des entrevues ont ete traitees par la methode de l’analyse de contenu. La theorie de Kanter a ete utile pour decrire les structures d’autonomisation dans les cours a distance. La retroaction des formateurs, l’acces a la bibliotheque et le soutien de l’employeur et de la famille sont des elements essentiels de l’autonomisation de l’experience educationnelle. Les etudiantes se sont ennuyees des rencontres en presentiel. Deux themes sans relation avec la theorie de Kanter – autogestion et la determination a reussir – ont emerges. Cette etude, basee sur un cadre theorique, interessera les educateurs et les administrateurs de programme d’education a distance.
THE PHAGOCYTOSIS AND INACTIVATION OF STAPHYLOCOCCI BY MACROPHAGES OF NORMAL RABBITS

The phagocytosis and survival of staphylococci in the presence of rabbit macrophages has been studied quantitatively. The method permitted an independent measurement to be made of intracellular and extracellular bacteria during the course of phagocytosis. It was found that S. aureus was relatively resistant to phagocytosis. In the presence of specific immune serum, however, it was ingested at a rate comparable with that of S. albus in normal serum; under these conditions more than 90 per cent of bacteria of either strain were inactivated within 60 minutes. Since immune serum did not alter the susceptibility of S. aureus to inactivation within macrophages, it is concluded that S. aureus and S. albus are similar in respect to their ability to survive within macrophages. The inactivation of staphylococci occurred more slowly, and a greater percentage survived incubation for 180 minutes, in macrophages than in polymorphonuclear leucocytes. Moreover, they retained their morphology for many hours within the former cell, but disappeared rapidly from the cytoplasm of granulocytes. It is suggested that the antibacterial mechanisms of the two cell types are fundamentally different. When studied over a prolonged period the staphylococci which survived early inactivation within macrophages were observed to die slowly over many hours. When they were recovered from cells and exposed to fresh macrophages, however, they were ingested and inactivated as readily as bacteria of the original population. It is suggested, therefore, that the prolonged survival in vitro of some staphylococci is due to variation in the efficiency of the antibacterial mechanism of exudative mononuclear phagocytes.
Utility of Viking Orbiter Images and Products for Mars Mapping

This paper reports on mapping procedures developed by the U.S. Geological Survey that use Viking Orbiter imagery and Mars Orbiter Laser Altimeter (MOLA) derived radii to produce topographic data. The use of Mosaiced Digital Image Models (MDIMs), created from Viking Orbiter images, and MOLA data to provide horizontal and vertical control is reviewed. We describe procedures to adapt a commercial digital photogrammetric workstation to work with planetary data.
Effects of ungulates on structure and species composition in the Urewera forests as shown by exclosures

Seventeen exclosures were built by the New Zealand Forest Service within Urewera forests over the period 1961-68 to exclude ungulates. Forest structure and species composition inside and outside these exclosures were compared in 1980-81. Some relatively shade tolerant species such as the fern Asplenium bulbiferum, the liane Ripogonum scandens, the sub-canopy shrubs Geniostoma ligustrifolium and Coprosma australis and the canopy species Beilschmiedia tawa were less abundant in certain tiers outside the exclosures than inside. By contrast, only a few species were more abundant outside then inside the exclosures. These included the unpalatable shrub Pseudowintera colorata, turf-forming Uncinia species and Cardamine debilis. Overall density and species richness for small diametered trees and for the sapling tier were lower outside the exclosures than inside. Despite the large reduction in ungulate numbers throughout Urewera forests these introduced browsing animals, particularly deer, still affect the structure and composition of most forest types.
Imaging oxytocin × dopamine interactions: an epistasis effect of CD38 and COMT gene variants influences the impact of oxytocin on amygdala activation to social stimuli

Although oxytocin (OT) has become a major target for the investigation of positive social processes, it can be assumed that it exerts its effects in concert with other neurotransmitters. One candidate for such an interaction is dopamine (DA). For both systems, genetic variants have been identified that influence the availability of the particular substance. A variant of the gene coding for the transmembrane protein CD38 (rs3796863), which is engaged in OT secretion, has been associated with OT plasma level. The common catechol-O-methyltransferase (COMT) val158met polymorphism is known to influence COMT activity and therefore the degradation of DA. The present study aimed to investigate OT × DA interactions in the context of an OT challenge study. Hence, we tested the influence of the above mentioned genetic variants and their interaction on the activation of different brain regions (amygdala, VTA, ventral striatum and fusiform gyrus) during the presentation of social stimuli. In a pharmacological cross-over design 55 participants were investigated under OT and placebo (PLA) by means of fMRI. Brain imaging results revealed no significant effects for VTA or ventral striatum. Regarding the fusiform gyrus, we could not find any effects apart from those already described in Sauer et al. (2012). Analyses of amygdala activation resulted in no gene main effect, no gene × substance interaction but a significant gene × gene × substance interaction. While under PLA the effect of CD38 on bilateral amygdala activation to social stimuli was modulated by the COMT genotype, no such epistasis effect was found under OT. Our results provide evidence for an OT × DA interaction during responses to social stimuli. We postulate that the effect of central OT secretion on amygdala response is modulated by the availability of DA. Therefore, for an understanding of the effect of social hormones on social behavior, interactions of OT with other transmitter systems have to be taken into account.
Comparison of Artificial Neural Network and Logistic Regression Models for Prediction of Psychological Symptom Six Months after Mild Traumatic Brain Injury

Background: Nowadays, outcome prediction models using logistic regression (LR) and artificial neural network (ANN) analysis have been developed in many areas of healthcare research. Objectives: In this study, we have compared the performance of multivariable LR and ANN models, in prediction of psychological symptoms six months after mild traumatic brain injury. Methods: In a prospective cohort study, information of 100 mild traumatic brain injury patients, during a six months period between 2014 and 2016 were included. Data were divided into two training (n = 50) and testing (n = 50) groups, randomly. 300 ANNs and LRs were studied in the first group and then the predicted values were compared in the second group using the two final models. The receiver operating characteristic (ROC) curve and accuracy rate were used to compare these models. Results: The results showed that accuracy rate for the neural network model was 90.65%, while it was 75.96% for the LR model. Conclusions: The ANN models appeared to be more powerful in predicting psychological symptoms versus the LR models.
Exploring protein domain organization by recognition of secondary structure packing interfaces

MOTIVATION Protein domains are fundamental units of protein structure, function and evolution; thus, it is critical to gain a deep understanding of protein domain organization. Previous works have attempted to identify key residues involved in organization of domain architecture. Because one of the most important characteristics of domain architecture is the arrangement of secondary structure elements (SSEs), here we present a picture of domain organization through an integrated consideration of SSE arrangements and residue contact networks. RESULTS In this work, by representing SSEs as main-chain scaffolds and side-chain interfaces and through construction of residue contact networks, we have identified the SSE interfaces well packed within protein domains as SSE packing clusters. In total, 17 334 SSE packing clusters were recognized from 9015 Structural Classification of Proteins domains of <40% sequence identity. The similar SSE packing clusters were observed not only among domains of the same folds, but also among domains of different folds, indicating their roles as common scaffolds for organization of protein domains. Further analysis of 14 small single-domain proteins reveals a high correlation between the SSE packing clusters and the folding nuclei. Consistent with their important roles in domain organization, SSE packing clusters were found to be more conserved than other regions within the same proteins. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Transcriptomic profiling of linolenic acid-responsive genes in ROS signaling from RNA-seq data in Arabidopsis

Linolenic acid (Ln) released from chloroplast membrane galactolipids is a precursor of the phytohormone jasmonic acid (JA). The involvement of this hormone in different plant biological processes, such as responses to biotic stress conditions, has been extensively studied. However, the role of Ln in the regulation of gene expression during abiotic stress situations mediated by cellular redox changes and/or by oxidative stress processes remains poorly understood. An RNA-seq approach has increased our knowledge of the interplay among Ln, oxidative stress and ROS signaling that mediates abiotic stress conditions. Transcriptome analysis with the aid of RNA-seq in the absence of oxidative stress revealed that the incubation of Arabidopsis thaliana cell suspension cultures (ACSC) with Ln resulted in the modulation of 7525 genes, of which 3034 genes had a 2-fold-change, being 533 up- and 2501 down-regulated genes, respectively. Thus, RNA-seq data analysis showed that an important set of these genes were associated with the jasmonic acid biosynthetic pathway including lypoxygenases (LOXs) and Allene oxide cyclases (AOCs). In addition, several transcription factor families involved in the response to biotic stress conditions (pathogen attacks or herbivore feeding), such as WRKY, JAZ, MYC, and LRR were also modified in response to Ln. However, this study also shows that Ln has the capacity to modulate the expression of genes involved in the response to abiotic stress conditions, particularly those mediated by ROS signaling. In this regard, we were able to identify new targets such as galactinol synthase 1 (GOLS1), methionine sulfoxide reductase (MSR) and alkenal reductase in ACSC. It is therefore possible to suggest that, in the absence of any oxidative stress, Ln is capable of modulating new sets of genes involved in the signaling mechanism mediated by additional abiotic stresses (salinity, UV and high light intensity) and especially in stresses mediated by ROS.
Coating with Autologous Plasma Improves Biocompatibility of Mesh Grafts In Vitro: Development Stage of a Surgical Innovation

Purpose. To investigate mesh coating modalities with autologous blood components in a recently developed in vitro test system for biocompatibility assessment of alloplastic materials. Materials and Methods. Seven different mesh types, currently used in various indications, were randomly investigated. Meshes were coated prior to cultivation with autologous peripheral blood mononuclear cells (PBMCs), platelets, and blood plasma. Pretreated meshes were incubated over 6 weeks in a minced tissue assay, representative for fibroblasts, muscle cells, and endothelial cells originating from 10 different patients. Adherence of those tissues on the meshes was microscopically investigated and semiquantitatively assessed using a previously described scoring system. Results. Coating with peripheral blood mononuclear cells did not affect the adherence score, whereas coating with platelets and blood plasma increased the score suggesting improved biocompatibility in vitro. The previous ranking of native meshes remained consistent after coating. Conclusion. Plasma coating of meshes improves their biocompatibility score in a novel in vitro test system.
A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the “iCOGS” custom genotyping array. All ∼200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were further tested in breast cancer cases (n = 11 024). We found a novel TL association (Ptrend < 4 × 10−10) at 3p14.4 close to PXK and evidence (Ptrend < 7 × 10−7) for TL loci at 6p22.1 (ZNF311) and 20q11.2 (BCL2L1). We additionally confirmed (Ptrend < 5 × 10−14) the previously reported loci at 3q26.2 (TERC), 5p15.3 (TERT) and 10q24.3 (OBFC1) and found supportive evidence (Ptrend < 5 × 10−4) for the published loci at 2p16.2 (ACYP2), 4q32.2 (NAF1) and 20q13.3 (RTEL1). SNPs tagging these loci explain TL differences of up to 731 bp (corresponding to 18% of total TL in healthy individuals), however, they display little direct evidence for association with breast, ovarian or prostate cancer risks.
An Examination and Revision of the Love Attitude Scale in Serbia

The research reports on results of an initial application of the Love Attitude Scale (Hendrick & Hendrick, 1986) in Serbia. The study was conducted on the sample of 127 respondents, mainly of adolescent age, from Subotica, Serbia. We explored the factor structure of the Love Attitude Scale, analyzed relationships between its subscales, and examined relevant correlates of its dimensions. We also performed extensive item analysis of the scale, and proposed several new items for the use in the revised Love Attitude Scale for Serbia. Correlates of the revised subscales correspond to those obtained with the original scale and in other countries. The results confirm cross-cultural stability of the six-dimensional structure of the Love Attitude Scale. It was concluded that the Serbian adaptation was successful, and that the translated and slightly revised scale can be used as a valid instrument for the assessment of the six love styles.
Genome-Wide Association of Heroin Dependence in Han Chinese

Drug addiction is a costly and recurring healthcare problem, necessitating a need to understand risk factors and mechanisms of addiction, and to identify new biomarkers. To date, genome-wide association studies (GWAS) for heroin addiction have been limited; moreover they have been restricted to examining samples of European and African-American origin due to difficulty of recruiting samples from other populations. This is the first study to test a Han Chinese population; we performed a GWAS on a homogeneous sample of 370 Han Chinese subjects diagnosed with heroin dependence using the DSM-IV criteria and 134 ethnically matched controls. Analysis using the diagnostic criteria of heroin dependence yielded suggestive evidence for association between variants in the genes CCDC42 (coiled coil domain 42; p = 2.8x10-7) and BRSK2 (BR serine/threonine 2; p = 4.110−6). In addition, we found evidence for risk variants within the ARHGEF10 (Rho guanine nucleotide exchange factor 10) gene on chromosome 8 and variants in a region on chromosome 20q13, which is gene-poor but has a concentration of mRNAs and predicted miRNAs. Gene-based association analysis identified genome-wide significant association between variants in CCDC42 and heroin addiction. Additionally, when we investigated shared risk variants between heroin addiction and risk of other addiction-related and psychiatric phenotypes using polygenic risk scores, we found a suggestive relationship with variants predicting tobacco addiction, and a significant relationship with variants predicting schizophrenia. Our genome wide association study of heroin dependence provides data in a novel sample, with functionally plausible results and evidence of genetic data of value to the field.
Conserved Meiotic Machinery in Glomus spp., a Putatively Ancient Asexual Fungal Lineage

Arbuscular mycorrhizal fungi (AMF) represent an ecologically important and evolutionarily intriguing group of symbionts of land plants, currently thought to have propagated clonally for over 500 Myr. AMF produce multinucleate spores and may exchange nuclei through anastomosis, but meiosis has never been observed in this group. A provocative alternative for their successful and long asexual evolutionary history is that these organisms may have cryptic sex, allowing them to recombine alleles and compensate for deleterious mutations. This is partly supported by reports of recombination among some of their natural populations. We explored this hypothesis by searching for some of the primary tools for a sustainable sexual cycle—the genes whose products are required for proper completion of meiotic recombination in yeast—in the genomes of four AMF and compared them with homologs of representative ascomycete, basidiomycete, chytridiomycete, and zygomycete fungi. Our investigation used molecular and bioinformatic tools to identify homologs of 51 meiotic genes, including seven meiosis-specific genes and other “core meiotic genes” conserved in the genomes of the AMF Glomus diaphanum (MUCL 43196), Glomus irregulare (DAOM-197198), Glomus clarum (DAOM 234281), and Glomus cerebriforme (DAOM 227022). Homology of AMF meiosis-specific genes was verified by phylogenetic analyses with representative fungi, animals (Mus, Hydra), and a choanoflagellate (Monosiga). Together, these results indicate that these supposedly ancient asexual fungi may be capable of undergoing a conventional meiosis; a hypothesis that is consistent with previous reports of recombination within and across some of their populations.
Recognition of digital modulations based on mathematical classifier

The paper describes a method for the classification of digital modulations. The method uses features computed from parameters of recognized signal such as instantaneous amplitude, instantaneous phase, and spectrum symmetry. The GentleBoost algorithm was used to analyze the features and classify the modulations. ASK, FSK, MSK, BPSK, QPSK, and QAM-16 were chosen for the classification as the best-known digital modulations used in modern communication technologies. The effectivity of the method designed was tested using signals corrupted by white Gaussian noise.
Low CD4/CD8 T-Cell Ratio Associated with Inflammatory Arthropathy in Human T-Cell Leukemia Virus Type I Tax Transgenic Mice

Background Human T-cell leukemia virus type I (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATL) as well as inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A transgenic mouse that expresses HTLV-1 Tax also develops T-cell leukemia/lymphoma and an inflammatory arthropathy that resembles rheumatoid arthritis. The aim of this study was to identify the primary T-cell subsets involved in the development of arthropathy in Tax transgenic mice. Principal Findings By 24 months of age, Tax transgenic mice developed severe arthropathy with a cumulative incidence of 22.8%. The pathological findings of arthropathy in Tax transgenic mice were similar to those seen in human rheumatoid arthritis or mouse models of rheumatoid arthritis, with synovial proliferation and a positive rheumatoid factor. Before the onset of spontaneous arthropathy, young and old Tax transgenic mice were not sensitive to collagen and did not develop arthritis after immunization with type II collagen. The arthropathic Tax transgenic mice showed a significantly decreased proportion of splenic CD4+ T cells, whereas the proportion of splenic CD8+ T cells was increased. Regulatory T cells (CD4+CD25+Foxp3+) were significantly decreased and CD8+ T cells that expressed the chemokine receptor CCR4 (CD8+CCR4+) were significantly increased in arthropathic Tax transgenic mice. The expression of tax mRNA was strong in the spleen and joints of arthropathic mice, with a 40-fold increase compared with healthy transgenic mice. Conclusions Our findings reveal that Tax transgenic mice develop rheumatoid-like arthritis with proliferating synovial cells in the joints; however, the proportion of different splenic T-cell subsets in these mice was completely different from other commonly used animal models of rheumatoid arthritis. The crucial T-cell subsets in arthropathic Tax transgenic mice appear to resemble those in HAM/TSP patients rather than those in rheumatoid arthritis patients.