Miracle-dz/UniFAR-FTUs huggingface dataset:
HOTAIR Interacting with MAPK1 Regulates Ovarian Cancer skov3 Cell Proliferation, Migration, and Invasion

Background The aim of this study was to evaluate the effect of when silencing HOTAIR in ovarian cancer skov3 cells on proliferation, migration, and invasion, and to elucidate the mechanism by which this occurs. Material/Methods We detected the mRNA level of HOTAIR (HOX antisense intergenic RNA) and MAPK1 (mitogen-activated protein kinase 1) in ovarian cancer SKOV3, ES-2, OVCAR3, A2780, and COC1 cell lines. We detected the mRNA level of HOTAIR and MAPK1 in ovarian SKOV3 when transected with miR-1, miR-214-3p, or miR-330-5p. We detected the mRNA and protein level of MAPK1 when silencing HOTAIR. We detected the expression of HOTAIR when silencing MAPK1. Then we detected the proliferation, migration, and invasion in ovarian cancer skov3 after silencing HOTAIR or MAPK1. Results The expression of HOTAIR and MAPK1 in ovarian SKOV3, ES-2, and OVCAR3 increased compared with A2780 and COC1 cells (P<0.05). The mRNA level of HOTAIR and MAPK1 in ovarian SKOV3 decreased when transected with miR-1, miR-214-3p, or miR-330-5p compared to negative control (p<0.05). The mRNA and protein level of MAPK1 was decreased when silencing HOTAIR and the mRNA level of HOTAIR was decreased when silencing MAPK1 (p<0.05). The proliferation, migration, and invasion was inhibited in ovarian SKOV3 after silencing HOTAIR or MAPK1 (p<0.05). Conclusions HOTAIR can promote proliferation, migration, and invasion in ovarian SKOV3 cells as a competing endogenous RNA.
Type P63 digitized color images performs better identification for ovarian reproductive tissue analysis

For pathology routine examination microscopic biopsy slides are considered as a most viable choice to analyze and identity ovarian reproductive tissues. Experts require substantial amount of time to process the biopsy slides under the microscope. Electronic modalities are not suitable to analyze smaller tissues especially ovarian reproductive tissues. To reduce the time and effort it would be a better choice to incorporate a computer based approach. In this paper existing research work related review has been carried out and a new modified approach has been presented. The proposed study results indicate improved and an acceptable accuracy rate in comparison to manual microscopic analysis and other existing computer based approaches.
Mass-loss and diffusion in subdwarf B stars and hot white dwarfs: do weak winds exist?

Context. According to previous investigations, the effect of diffusion in the stellar atmospheres and envelopes of hot white dwarfs and subdwarf B (sdB) stars strongly depends on the presence of weak winds with mass-loss rates $\dot M$ -11 $M_{\odot}/\rm yr$. Aims. As in most of these stars with luminosities $L /L_{\odot}$ $\la$ 100, no wind signatures have been detected, the mass-loss rates are unknown. In the present paper mass-loss rates are predicted from the original theory of radiatively driven winds. Methods. The method of solution is modified so that the usual parametrization of the line force multipliers is not necessary. This is important especially for very thin winds. In addition we checked whether a one-component description is justified. As a consequence of various simplifications, the mass-loss rates are expected to be overestimated. Results. Results are presented for effective temperatures in the range 25 000 K ≤ T eff ≤ 50 000 K and for various metallicities between solar and $Z / Z_{\odot}$ = 0.01. For (pre-) white dwarfs and sdB stars a stellar mass of $M_{*}$ = 0.5 $M_{\odot}$ is assumed. For fixed values of T eff , $M_{*}$, and Z , the results predict decreasing mass-loss rates with increasing surface gravity and an increasing dependence of the mass-loss rates on the metallicity. For white dwarfs with log g > 7.0 no wind solution exists even if the metallicity would be solar. Winds with mass-loss rates around 10 -11 to 10 -10 $M_{\odot} / \rm yr$ are predicted for the most luminous sdB stars with surface gravities of log g $\la$ 5.5, if the metallicity is not significantly lower than solar. For lower values of $\dot M$ metals decouple from hydrogen and helium. Conclusions. If weak winds with $\dot M$ $\la$ 10 -12 $M_{\odot} / \rm yr$ exist, the metals cannot be coupled to hydrogen and helium. This should lead to additional changes in the surface composition, which have not yet been taken into account in the diffusion calculations with and without mass-loss. A possible scenario is the existence of pure metallic winds with mass-loss rates of $\dot M$ $\la$ 10 -16 $M_{\odot} / \rm yr$ and with hydrostatic hydrogen and helium.
Bioaccumulation Experiments in Mussels Contaminated with the Food-Borne Pathogen Arcobacter butzleri: Preliminary Data for Risk Assessment

The aim of this study was to evaluate, at a laboratory scale, the ability of this microorganism to grow in seawater and bioaccumulate in mussels (Mytilus galloprovincialis) maintained in constantly aerated tanks, containing twenty litres of artificial seawater. Three concentrations of A. butzleri LMG 10828T were tested (about 5 × 106 CFU/mL, 5 × 104 CFU/mL, and 5 × 102 CFU/mL). Following contamination, enumeration of A. butzleri was performed from water and mussels each day, for up to 96 h. Three contamination experiments with artificial seawater in absence of mussels were also performed in the same manner. In the experiments with mussels, A. butzleri declined in water of approximately 1 log every 24 h from the contamination. In artificial seawater without mussels the concentration of A. butzleri remained on the same logarithmic level in the first 48 h and then decreased of about 1 log every 24 hours. In mussels, the concentration was approximately 2 log lower than the exposition level after 24 h from the contamination, and then it decreased exponentially of 1 log every 24 h. Our findings suggest that in the experimental conditions tested A. butzleri is neither able to effectively grow in seawater nor bioaccumulate in mussels, at least in the free and cultivable form.
Loopy Logic

In this paper we describe a new logic-based stochastic modeling language. It is an extension of the Bayesian logic programming approach of Kersting and De Raedt [1]. We specialize the Kirsting and De Raedt formalism by suggesting that product distributions are an effective combining rule for Horn clause heads. We use a refinement of Pearl’s loopy belief propagation [2] for the inference algorithm. We also extend the Kirsting and De Raedt language by adding learnable distributions. We propose a message passing algorithm based on Expectation Maximization for estimating the learned parameters in the general case of models built in our system. We have also added some additional utilities to our logic language including second order unification and equality predicates.
FEMALE REPRODUCTIVE SUCCESS OF NARROW ENDEMIC ERODIUM PAULARENSE IN CONTRASTING MICROHABITATS

In 1996, we investigated the female reproductive success of the narrow endemic Erodium paularense in a population with a mixture of rock and lithosol micro- habitats. The main purposes of this study were to determine the main factors that affected reproductive success and whether these factors were influenced by differences in the two contrasting microhabitats. In both microhabitats, fruit set was low, and seed abortion rates were very high. Lithosol plants were larger and had higher flower, fruit, and seed production than rock plants. We used structural equation modeling (SEM) to analyze the effects of plant size, phenological variables, competition, and flowering synchrony on fecundity and to compare path coefficients among microhabitats. In both microhabitats reproductive suc- cess was strongly predicted by plant size and to a lesser extent by flowering synchrony. Flowering moment and intensity did not have a significant effect on fruit set, suggesting that pollinator availability is not a limiting factor in total seed production. This was further corroborated by hand-pollination experiments. Resource limitations, inbreeding depression, and environmental restrictions may be responsible for the high rates of seed abortion. Multisample comparison of path coefficients for the two microhabitats rejected the pos- sibility that reproductive patterns could be described by one single model. The main di- vergences in both microhabitat models were related to competition. Reproductive data from 1995, a year with below-average rainfall, showed remarkably lower seed production at the lithosol microhabitat and similar values at the rock microhabitat as compared to 1996. The variation of the reproductive parameters between the two years was evaluated by multi- sample analyses in which 1995 data were fed into the 1996 models. At the lithosol micro- habitat, two constrained paths involving seed production produced a significant decrease in fit, whereas at the rock microhabitat, significant differences were found in three paths involving only phenological variables. Thus, the lithosol microhabitat may contribute to greater seed production in favorable years while the rock microhabitat may provide more stable conditions over time.
Saccadic eye movement disturbances in whiplash patients with persistent complaints.

In order to analyse the possible basis of subjective complaints following whiplash injury, horizontal eye movements were examined in subjects with persistent complaints ('symptomatic group') and subjects who had completely recovered ('recovered group'). The results for the symptomatic and recovered groups were compared with those for age-matched, healthy volunteers (control group). A battery of different saccade paradigms was employed: two were reflexive saccade tasks including a gap and an overlap task, and two were intentional saccade tasks consisting of an antisaccade and a memory-guided saccade task. In addition, the symptomatic and recovered groups also underwent psychiatric evaluation in a structured clinical interview, and all groups were assessed for emotional functioning using the Beck Depression Inventory (BDI). The recovered group did not differ significantly from the control group in saccade performance and emotional functioning. The symptomatic group showed dissociation of their performances of reflexive and intentional saccade tasks: performance in reflexive saccade tasks was normal, but in intentional saccade tasks the symptomatic group showed significantly impaired inhibition of unwanted reflexive saccades, impaired saccade triggering (i.e. increased latency) and a higher percentage error in amplitude in memory-guided saccades. Based on clinical interviews, no signs of major depression or dysthymia were found in any of the groups. Compared with the other two groups, the symptomatic group had significantly higher overall BDI scores, but these resulted from BDI dimensions that were non-specific to depression, viz. 'physiological manifestations' (e.g. fatigue, sleep disturbance) or 'performance difficulty' (e.g. work inhibition). In summary, in the symptomatic group the pattern of eye movement disturbances together with normal performance in reflexive saccade tasks and impaired performance in the intentional saccade tasks, especially impaired inhibitory function, suggests dysfunction of prefrontal and frontal cortical structures.
Issue S in Informing Science and Information Technology University Enhancement System Using a Social Networking Approach: Extending E-learning

The proliferation of e-learning systems in both learning institutions and companies has contributed a lot to the acquisition and application of new skills. With the growth in technology, especially the internet, e-learning systems are only getting better and having more impact on the users. This paper suggests an approach to e-learning that emphasizes active and open collaboration, and also the integration of other services that aid or contribute to the learning process. This approach aims at having an extended and enhanced learning environment that is tied or connected to other systems within the immediate environment or otherwise. We illustrate the possibility and usability of such system in a university, such that other important administrative systems are integrated into the e-learning system, and collaboration is open to both academic and non-academic personnel's.
Ethnic differences and socio-demographic predictors of illness perceptions, self-management, and metabolic control of type 2 diabetes

Objectives This study investigated ethnic differences in diabetes-specific knowledge, illness perceptions, self-management, and metabolic control among black-African, black-Caribbean,and white-British populations with type 2 diabetes. The study also examined associations between demographic/disease characteristics and diabetes-specific knowledge, illness perceptions, self-management, and metabolic control in each of the three ethnic groups. Design Cross-sectional Setting Diabetes/retinal screening clinics in Hackney and Brent, London. Methods Black-African, black-Caribbean and white-British populations with type 2 diabetes were asked to participate. Questionnaires measuring demographic/disease characteristics, diabetes-specific knowledge, self-management, and illness perceptions were used for data collection. Data for glycated hemoglobin (HbA1c) and microvascular complications were obtained from medical records. Ethnic differences in diabetes-related measures were estimated using analysis of variance/covariance. Multiple regression techniques were used to determine relationships between demographic/disease characteristics and measured diabetes-related outcomes. Results Three hundred and fifty-nine patients participated in the study. White-British participants had high diabetes-specific knowledge compared to their black-African and black-Caribbean counterparts. Black-Africans reported better adherence to self-management recommendations than the other ethnic groups. Compared to the white-British patients, black-African and black-Caribbean participants perceived diabetes as a benign condition that could be cured. Educational status and treatment category were determinants of diabetes-specific knowledge in all three ethnic groups. However, different demographic/disease characteristics predicted adherence to self-management recommendations in each ethnic group. Conclusion Clearly, there is disease (diabetes) knowledge-perception variation between different ethnic groups in the UK which may partly influence overall disease outcome. It is plausible to recommend screening, identifying, and dispelling misconceptions about diabetes among ethnic minority patients by health care professionals as well as emphasizing the importance of self-management in managing chronic diseases such as diabetes.
Lobaplatin-TACE combined with radioactive 125I seed implantation for treatment of primary hepatocellular carcinoma.

AIM To investigate the efficacy and safety of lobaplatin-transcatheter arterial chemoembolization (TACE) combined with radioactive 125I seed implantation in treatment of primary hepatocellular carcinoma (HCC). METHODS 75 patients with primary HCC were enrolled in the study, among them 43 receiving lobaplatin- TACE (TACE group) and 32 lobaplatin-TACE combined with 125I seed implantation (TACE+125I group). After treatment, the local remission rates and postoperative complications of two groups were compared using the Pearson Chi-square test. Overall survival in the two groups was calculated using Kaplan-Meier survival curves and the differences were tested using Log-rank test. RESULTS There were 7 cases of complete response (CR), 13 of partial response (PR), 6 of stable disease (SD) and 17 of progressive disease (PD) in the TACE group, with 13 cases of CR, 9 of PR, 5 of SD and 5 of PD in the TACE+125I group. The disease control rates of TACE and TACE+125I group were 60.5% (26/43) and 84.4% (27/32), respectively, with a significant difference between them (P < 0.05). The survival rates at 6, 12 and 18 months in the TACE group were 100.0%, 81.8% and 50.0%, respectively, and those in TACE+125I group were 100.0%, 93.8% and 65.6%. The mean survival times in the TACE and TACE+125I groups were 19.5 and 22.9 months, respectively. There was a significant difference in the overall survival rate between two groups (P < 0.05). No serious complications were encountered in either group. CONCLUSION Lobaplatin-TACE combined with 125I seed implantation is favorable and safe for treatment of primary HCC.
Lower extremity joint kinematics of stair ascent in transfemoral amputees

Background: Stair ascent is a very demanding task for transfemoral amputees (TFAs). The purpose of this study was to investigate the lower extremity joint kinematics of TFAs who can climb stairs using a step-over-step gait pattern without an active artificial prosthetic knee joint or handrail use. Case Description and Methods: Case series. Participants were two traumatic TFAs and 10 control participants. Both TFAs used a single-axis prosthetic knee joint in daily living. Sagittal plane joint kinematics were recorded at 60 Hz using an eight-camera motion analysis system and digital video camera. Findings and Outcomes: From the instant of touchdown, the prosthetic knee joint was rapidly extended and remained fully extended until toe-off. In the latter half of the stance phase, the knee and ankle joints of the sound limb simultaneously showed rapid joint flexion during continuous extension. Further, the ankle joint of the sound limb showed greater plantarflexion at the end of the stance phase. Conclusion: These results suggest that the TFA in the present study would (1) extend the prosthetic knee joint to prevent the knee flexion generated by the bodyweight (plus ground reaction force and/or joint moment), and (2) lift the whole body in an upward direction using strong counter-movements and greater joint extension during the stance phase.
School-based management: leadership hand in hand

Terrence O'Connor, Jr. School-Based Management May 2003 Dr. Dennis Hurley School Administration/Supervision This study, conducted in order to determine the effectiveness of the school-based management team, occurred at the Reeds Road Elementary School. An action research design, using both surveys and interviews, assisted in obtaining the data necessary to make an appropriate determination of the initiative's effectiveness in providing staff with more say in school affairs, as well as positively affecting the school's climate. Twentytwo staff members, chosen randomly to best represent all areas of the school's staff population, completed surveys regarding the school-based management team. In addition, six different staff members were also chosen randomly to participate in an interview process. (3 females and 3 males). The results of this study indicate that, despite some areas of concern to staff, the school-based management team does, in fact, provide staff with an outlet to voice their concerns and ideas about various school affairs. The data reflected that the team does seem to enhance the overall atmosphere at the school. This study found that staff appear to hold their school in higher esteem when they feel that they can participate in its governance and that their concerns and ideas will not only be heard but also addressed, as well.
Prognostic and Predictive Blood-Based Biomarkers in Patients with Advanced Pancreatic Cancer: Results from CALGB80303 (Alliance)

Purpose: CALGB80303 was a phase III trial of 602 patients with locally advanced or metastatic pancreatic cancer comparing gemcitabine/bevacizumab versus gemcitabine/placebo. The study found no benefit in any outcome from the addition of bevacizumab to gemcitabine. Blood samples were collected and multiple angiogenic factors were evaluated and then correlated with clinical outcome in general (prognostic markers) and with benefit specifically from bevacizumab treatment (predictive markers). Experimental Design: Plasma samples were analyzed via a novel multiplex ELISA platform for 31 factors related to tumor growth, angiogenesis, and inflammation. Baseline values for these factors were correlated with overall survival (OS) using univariate Cox proportional hazard regression models and multivariable Cox regression models with leave-one-out cross validation. Predictive markers were identified using a treatment by marker interaction term in the Cox model. Results: Baseline plasma was available from 328 patients. Univariate prognostic markers for OS were identified including: Ang2, CRP, ICAM-1, IGFBP-1, TSP-2 (all P < 0.001). These prognostic factors were found to be highly significant, even after adjustment for known clinical factors. Additional modeling approaches yielded prognostic signatures from multivariable Cox regression. The gemcitabine/bevacizumab signature consisted of IGFBP-1, interleukin-6, PDGF-AA, PDGF-BB, TSP-2; whereas the gemcitabine/placebo signature consisted of CRP, IGFBP-1, PAI-1, PDGF-AA, P-selectin (both P < 0.0001). Finally, three potential predictive markers of bevacizumab efficacy were identified: VEGF-D (P < 0.01), SDF1 (P < 0.05), and Ang2 (P < 0.05). Conclusion: This study identified strong prognostic markers for pancreatic cancer patients. Predictive marker analysis indicated that plasma levels of VEGF-D, Ang2, and SDF1 significantly predicted for benefit or lack of benefit from bevacizumab in this population. Clin Cancer Res; 19(24); 6957–66. ©2013 AACR.
On the Design of Configurable Modulo 2n±1 Residue Generators

In this work new efficient modulo 2<sup>n</sup>+1 residue generators are proposed. The input operands are divided into n-bit vectors which are added by an inverted end around carry save adder tree and a final stage diminished-1 modulo 2<sup>n</sup>+1 adder. The conversion of the proposed residue generators to configurable modulo 2<sup>n</sup>±1 ones is also discussed. Modulo 2<sup>n</sup>±1 residue generators find applicability as forward converts from the binary to the residue number system, and in the design of self-checking digital systems.
Early‐A stars from IPHAS, and their distribution in and around the Cyg OB2 association

Stellar photometry derived from the INT/WFC Photometric HSurvey of the North- ern Galactic Plane (IPHAS) can be used to identify large, reliable samples of A0-A5 dwarfs. For every A star, so identified, it is also possible to derive individual reddening and distance estimates, under the assumption that most selected objects are on or near the main sequence, at a mean absolute rmagnitude of 1.5 - 1.6. This study presents the method for obtaining such samples and shows that the known reddenings and distances to the open clusters NGC 7510 and NGC 7790 are successfully recovered. A sample of over 1000 A stars is then obtained from IPHAS data in the magnitude range 13.5 < r ' < 20 from the region of sky including the massive northern OB association Cyg OB2. Analysis of these data reveals a concentration of �200 A stars over an area about a degree across, offset mainly to the south of the known 1-3 Myr old OB stars in Cyg OB2: their dereddened rmagnitudes fall in the range 11.8 to 12.5. These are consistent with a � 7 Myr old stellar population at DM = 10.8, or with an age of � 5 Myr at DM = 11.2. The number of A stars found in this clustering alone is consistent with a lower limit to the cluster mass of � 10 4 M⊙.