Miracle-dz/UniFAR-FTUs huggingface dataset:
SIMULATIONS OF THE MICROWAVE SKY

We create realistic, full-sky, half-arcminute resolution simulations of the microwave sky matched to the most recent astrophysical observations. The primary purpose of these simulations is to test the data reduction pipeline for the Atacama Cosmology Telescope (ACT) experiment; however, we have widened the frequency coverage beyond the ACT bands and utilized the easily accessible HEALPix map format to make these simulations applicable to other current and near future microwave background experiments. Some of the novel features of these simulations are that the radio and infrared galaxy populations are correlated with the galaxy cluster and group populations, the primordial microwave background is lensed by the dark matter structure in the simulation via a ray-tracing code, the contribution to the thermal and kinetic Sunyaev–Zel'dovich (SZ) signals from galaxy clusters, groups, and the intergalactic medium has been included, and the gas prescription to model the SZ signals has been refined to match the most recent X-ray observations. The cosmology adopted in these simulations is also consistent with the WMAP 5-year parameter measurements. From these simulations we find a slope for the Y200–M200 relation that is only slightly steeper than self-similar, with an intrinsic scatter in the relation of ∼14%. Regarding the contamination of cluster SZ flux by radio galaxies, we find for 148 GHz (90 GHz) only 3% (4%) of halos have their SZ decrements contaminated at a level of 20% or more. We find the contamination levels higher for infrared galaxies. However, at 90 GHz, less than 20% of clusters with M200 > 2.5 × 1014M☉ and z < 1.2 have their SZ decrements filled in at a level of 20% or more. At 148 GHz, less than 20% of clusters with M200 > 2.5 × 1014M☉ and z < 0.8 have their SZ decrements filled in at a level of 50% or larger. Our models also suggest that a population of very high flux infrared galaxies, which are likely lensed sources, contribute most to the SZ contamination of very massive clusters at 90 and 148 GHz. These simulations are publicly available and should serve as a useful tool for microwave surveys to cross-check SZ cluster detection, power spectrum, and cross-correlation analyses.
10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling

Royal jelly (RJ) produced by honeybees has been reported to possess diverse health-beneficial properties and has been implicated to have a function in longevity across diverse species as well as honeybees. 10-Hydroxy-2-decenoic acid (10-HDA), the major lipid component of RJ produced by honeybees, was previously shown to increase the lifespan of Caenorhabditis elegans. The objective of this study is to elucidate signaling pathways that are involved in the lifespan extension by 10-HDA. 10-HDA further extended the lifespan of the daf-2 mutants, which exhibit long lifespan through reducing insulin-like signaling (ILS), indicating that 10-HDA extended lifespan independently of ILS. On the other hand, 10-HDA did not extend the lifespan of the eat-2 mutants, which show long lifespan through dietary restriction caused by a food-intake defect. This finding indicates that 10-HDA extends lifespan through dietary restriction signaling. We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15, which encodes Raptor, a target of rapamycin (TOR) components, indicating that 10-HDA shared some longevity control mechanisms with TOR signaling. Additionally, 10-HDA was found to confer tolerance against thermal and oxidative stress. 10-HDA increases longevity not through ILS but through dietary restriction and TOR signaling in C. elegans.
The Journal of General Physiology

Hubbard has found that the photoisomerization of retinene was important for the regeneration of rhodopsin in ¢itro, and the object of the present investigation was to find whether this was also true for regeneration in the living human eye. In the Appendix is described a device which permits the rhodopsin density to be measured by analysing the light reflected from the fundus oculi in an ophthalmoscopic arrangement, the measurement taking about 5 seconds. Now if a blue and a yellow light viewed scotopically are adjusted in intensity so as to appear identical, they must bleach rhodopsin equally, but the blue will be more than 10 times as effective in isomerizing retinene. Therefore if retinene isomerization is important for rhodop-sin regeneration, blue light should cause a more rapid regeneration after bleaching, and during bleaching the equilibrium level attained should be less profound. But, as the figures show, the course of bleaching and regeneration is identical for the matched yellow or blue bleaching lights, therefore isomerization of retinene is not important for rhodopsin regeneration in the living human eye. The ancient problem of the regeneration of rhodopsin was seen in a new light when Hubbard and Wald (1952-53) discovered the importance of the particular isomer of retinene involved. When rhodopsin is bleached, the reti-nene liberated is the all-trans form, but for regeneration to be effective a cis-isomer (named neo-retinene b) is required. If, therefore, the retinene liberated upon bleaching is to be used again it needs to be isomerized. 1954) shows that the retinene from bleached rhodopsin can be synthesised to form new rhodopsin but that a water-soluble factor extracted from the retina or pigment epithelium is necessary. The possibility that the water-soluble factor contains an isomerizing enzyme was investigated by Hubbard, and in a recent paper (1956) she has shown that "retinene isomerase" is in fact present and she has described its preparation and principal characteristics when acting in a simple system in which all the reagents are precisely specified. In the dark, the enzyme is not very effective in generating the required neo-b isomer, for the equilibrium proportions turn out to be 95 per cent a11-419
Sibyl: A Practical Internet Route Oracle

Network operators measure Internet routes to troubleshoot problems, and researchers measure routes to characterize the Internet. However, they still rely on decades-old tools like traceroute, BGP route collectors, and Looking Glasses, all of which permit only a single query about Internet routes--what is the path from here to there? This limited interface complicates answering queries about routes such as "find routes traversing the Level3/AT&T peering in Atlanta," to understand the scope of a reported problem there. This paper presents Sibyl, a system that takes rich queries that researchers and operators express as regular expressions, then issues and returns traceroutes that match even if it has never measured a matching path in the past. Sibyl achieves this goal in three steps. First, to maximize its coverage of Internet routing, Sibyl integrates together diverse sets of traceroute vantage points that provide complementary views, measuring from thousands of networks in total. Second, because users may not knowwhich measurements will traverse paths of interest, and because vantage point resource constraints keep Sibyl from tracing to all destinations from all sources, Sibyl uses historical measurements to predict which new ones are likely to match a query. Finally, based on these predictions, Sibyl optimizes across concurrent queries to decide which measurements to issue given resource constraints. We show that Sibyl provides researchers and operators with the routing information they need--in fact, it matches 76% of the queries that it could match if an oracle told it which measurements to issue.
The valence-fluctuating ground state of plutonium

Determination of plutonium’s fluctuating electronic and magnetic ground state resolves long-standing “missing” magnetism puzzle. A central issue in material science is to obtain understanding of the electronic correlations that control complex materials. Such electronic correlations frequently arise because of the competition of localized and itinerant electronic degrees of freedom. Although the respective limits of well-localized or entirely itinerant ground states are well understood, the intermediate regime that controls the functional properties of complex materials continues to challenge theoretical understanding. We have used neutron spectroscopy to investigate plutonium, which is a prototypical material at the brink between bonding and nonbonding configurations. Our study reveals that the ground state of plutonium is governed by valence fluctuations, that is, a quantum mechanical superposition of localized and itinerant electronic configurations as recently predicted by dynamical mean field theory. Our results not only resolve the long-standing controversy between experiment and theory on plutonium’s magnetism but also suggest an improved understanding of the effects of such electronic dichotomy in complex materials.
The examination of the differences in the motor proficiency skills of children practising gymnastics vs. non-sportive children

ABSTRACT This study aimed to investigate whether or not gymnastics is effective to develop 60–72-month-old children’s motor skills. The participants were selected from two different preschools in the same district of Ankara, Turkey. While half of the children participated in regular gymnastic activities in their schools, the remaining part of them did not participate in any kind of sportive activities. As a data gathering instrument, the Bruininks-Oseretsky motor proficiency test was used to measure the participants’ motor skills. The test consists of eight sub-tests in original, which are running speed and agility, balance, bilateral coordination, strength, upper-limb coordination, response speed, visual-motor control, upper-limb speed, and dexterity. The results revealed that children participating in gymnastic programme achieved higher scores on speed and agility, balance, bilateral coordination, strength, upper-limb coordination, response speed, and visual-motor control than the non-sportive group of children.
Journal of Experimental Pharmacology Dovepress

8313 The influence of dexamethasone and the role of some antioxidant vitamins in the pathogenesis of experimental bronchial asthma Background: Bronchial asthma is a disease characterized by paroxysmal and reversible obstruction of the airways. The imbalance between the oxidant and antioxidant system that is called oxidative stress is critical in asthma pathogenesis. It is likely, therefore, that antioxidants may be effective in the treatment of asthma. Systemic treatment with glucocorticoids has been reported to inhibit smooth muscle hypercontraction which may account partially for their beneficial effects in the treatment of asthma. Objective: The present study was conducted in order to study the effect of dexamethasone and some antioxidant vitamins on interleukin-4 (IL-4), immunoglobulin E (IgE) and heat shock protein 70 (Hsp70) in bronchial asthma in rats, and to recognize their possible beneficial role. Method: The study was conducted on 60 adult male albino rats randomly divided into 4 groups (15 for each group): including normal control group (group A); asthma model group where rats were sensitized by ovalbumin and challenged with antigen aerosol producing bronchial asthma (group B); asthma model group treated with antioxidant vitamins (vitamin E and vitamin C) (group C); asthma model group treated with dexamethasone (group D). Blood and lung samples were collected from all groups. Results and Conclusion: Our results revealed a significant decrease of serum reduced glutathione (GSH) levels among groups B, C and D as compared to group A, while there was a significant increase in group C and D as compared to group B. Antioxidant and dexametha-sone treatment resulted in a significant decrease of serum IL-4, malondialdehyde (MDA), and serum IgE levels in group C and D as compared to group B. Antioxidant treatment resulted in a significant decrease of serum Hsp70 level as compared to group B, while dexamethasone treatment resulted in a significant increase of serum Hsp70 level as compared to group B. This study suggests that it is likely that a combination of antioxidant vitamins may be effective in the treatment of asthma, considering their reported effects on lowering MDA, IL-4, and IgE levels, and the similar beneficial effects of dexamethasone in addition to increasing the expression of Hsp70 in the studied model of bronchial asthma.
Evaluating the Atrial Myopathy Underlying Atrial Fibrillation: Identifying the Arrhythmogenic and Thrombogenic Substrate

Atrial disease or myopathy forms the substrate for atrial fibrillation (AF) and underlies the potential for atrial thrombus formation and subsequent stroke. Current diagnostic approaches in patients with AF focus on identifying clinical predictors with the evaluation of left atrial size by echocardiography serving as the sole measure specifically evaluating the atrium. Although the atrial substrate underlying AF is likely developing for years before the onset of AF, there is no current evaluation to identify the preclinical atrial myopathy. Atrial fibrosis is 1 component of the atrial substrate that has garnered recent attention based on newer MRI techniques that have been applied to visualize atrial fibrosis in humans with prognostic implications regarding the success of treatment. Advanced ECG signal processing, echocardiographic techniques, and MRI imaging of fibrosis and flow provide up-to-date approaches to evaluate the atrial myopathy underlying AF. Although thromboembolic risk is currently defined by clinical scores, their predictive value is mediocre. Evaluation of stasis via imaging and biomarkers associated with thrombogenesis may provide enhanced approaches to assess risk for stroke in patients with AF. Better delineation of the atrial myopathy that serves as the substrate for AF and thromboembolic complications might improve treatment outcomes. Furthermore, better delineation of the pathophysiologic mechanisms underlying the development of the atrial substrate for AF, particularly in its earlier stages, could help identify blood and imaging biomarkers that could be useful to assess risk for developing new-onset AF and suggest specific pathways that could be targeted for prevention.
Journal of Modern Applied Statistical Methods Approximation Multivariate Distribution of Main Indices of Tehran Stock Exchange with Pair-copula Approximation Multivariate Distribution of Main Indices of Tehran Stock Exchange with Pair-copula

The multivariate distribution of five main indices of Tehran stock exchange is approximated using a pair-copula model. A vine graphical model is used to produce an í µí±-dimensional copula. This is accomplished using a flexible copula called a minimum information (MI) copula as a part of pair-copula construction. Obtained results show that the achieved model has a good level of approximation.
Emotional expressions evoke a differential response in the fusiform face area

It is widely assumed that the fusiform face area (FFA), a brain region specialized for face perception, is not involved in processing emotional expressions. This assumption is based on the proposition that the FFA is involved in face identification and only processes features that are invariant across changes due to head movements, speaking and expressing emotions. The present study tested this proposition by examining whether the response in the human FFA varies across emotional expressions with functional magnetic resonance imaging and brain decoding analysis techniques (n = 11). A one vs. all classification analysis showed that most emotional expressions that participants perceived could be reliably predicted from the neural pattern of activity in left and the right FFA, suggesting that the perception of different emotional expressions recruit partially non-overlapping neural mechanisms. In addition, emotional expressions could also be decoded from the pattern of activity in the early visual cortex (EVC), indicating that retinotopic cortex also shows a differential response to emotional expressions. These results cast doubt on the idea that the FFA is involved in expression invariant face processing, and instead indicate that emotional expressions evoke partially de-correlated signals throughout occipital and posterior temporal cortex.
Alleviate Chip Pin Constraint for Multicore Processor by On/Off-Chip Power Delivery System Codesign

The number of chip pins is limited due to the cost and reliability issues of sophisticated packages, and it is predicted that the chip pin count will be overstretched to satisfy the requirements of both power delivery and memory access. The gap between the achievable pin count and the demand will increase as the technology scales, due to the increasing computation resources and supply current. Pin reduction techniques are thus required for continued computing performance growth. In this article, we propose a chip pin constraint alleviation strategy, through on/off-chip power delivery system co-design, to effectively reduce the demand for power pins. An analytical model of a power delivery system, consisting of on/off-chip regulators and a power delivery network, is proposed to evaluate the influence of regulator design and package conduction loss. By combining this model with a multi-core processor model of performance and memory bandwidth requirements, we characterize the entire multi-core processor system to investigate the relationship between the chip pin constraint and performance in multi-core processor scaling and the effectiveness of our strategy. Experiments show that with the conventional power delivery system design, the chip pin constraint severely limits the performance growth as the technology scales. Using the on/off-chip power delivery system co-design, our strategy achieves a significant pin count reduction, for example, 31.3% at the 8nm technology node, compared to the conventional design with the same chip performance, while, provided with the same chip pin count, it is able to improve, by 35.0%, the chip performance at 8nm compared to the conventional design. For real applications of different parallelism, our strategy outperforms its counterpart, with a 23.7% performance improvement on average at the 8nm technology node.
Teachers’ motivations for master’s degree programs in education in Israeli teacher training institutions and the implications for government policy-making concerning those programs

ABSTRACT The study aimed to identify teachers’ motivations to study Master of Education (M.Ed.) programs offered by teachers’ training colleges. M.Ed. degree programs have become available in Israel since 2004, with a rapid increase since then in the number of colleges offering various programs and a consequent increase in the number of graduates. M.Ed. degrees follow one of two teaching approaches: (1) top-down/transmission of knowledge (2) bottom-up transformative studies to support teachers’ professional autonomy. The first approach complies with the policy of the Council for Higher Education (CHE). The other is promoted by the Israeli Ministry of Education as an integral part of teachers’ professional development. The study’s methodology included examining data from multiple sources: documentation concerning the academic programs, government policy statements, and surveys administered to teachers who had graduated successfully from M.Ed. programs over the past decade and are now working in the field. We found that after the first decade of M.Ed. courses in Israel, significantly more programs incline towards the bottom-up/transformative approach, aiming to promote individual, personal and professional development instead of adopting the transmission approach. Teachers prefer M.Ed. programs at universities that include research. Yet their motivation to study is primarily intrinsic motivation, whether they aspire to study at universities or at teachers’ training colleges. Results are pertinent for government planning of teachers’ professional development. Further study into the needs of teachers is required to endorse these conclusions.
The Neuronal Ceroid–Lipofuscinoses

The neuronal ceroid-lipofuscinoses (NCLs) collectively constitute the most common group of neurodegenerative diseases in childhood and usually show an autosomal recessive mode of inheritance. Despite varying ages of onset and clinical course characterized in most instances by progressive mental and motor deterioration, blindness, epileptic seizures, and premature death, all forms of NCL show unifying histopathological features. There is accumulation of autofluorescent, periodic acid-Schiff-, and Sudan black B-positive granules that are resistant to lipid solvents in the cytoplasm of most nerve cells and, to a lesser degree, of many other cell types. The storage process is associated with progressive and selective neuronal loss and gliosis with secondary white matter lesions. The ultrastructure of the storage deposits varies between different forms of NCL and, along with the age of onset, has provided the basis for the traditional classification of NCLs. Recent molecular genetic findings have established that defects in at least 7 different genes underlie the various forms of NCL. The purpose of this paper is to provide an overview of the NCLs, review recent molecular genetic and biochemical findings, and discuss their impact on our views on the classification and pathogenesis of these devastating brain disorders.
Predicting Near-Future Churners and Win-Backs in the Telecommunications Industry

In this work, we presented the strategies and techniques that we have developed for predicting the near-future churners and win-backs for a telecom company. On a large-scale and real-world database containing customer profiles and some transaction data from a telecom company, we first analyzed the data schema, developed feature computation strategies and then extracted a large set of relevant features that can be associated with the customer churning and returning behaviors. Our features include both the original driver factors as well as some derived features. We evaluated our features on the imbalance corrected dataset, i.e. under-sampled dataset and compare a large number of existing machine learning tools, especially decision tree-based classifiers, for predicting the churners and win-backs. In general, we find RandomForest and SimpleCart learning algorithms generally perform well and tend to provide us with highly competitive prediction performance. Among the top-15 driver factors that signal the churn behavior, we find that the service utilization, e.g. last two months' download and upload volume, last three months' average upload and download, and the payment related factors are the most indicative features for predicting if churn will happen soon. Such features can collectively tell discrepancies between the service plans, payments and the dynamically changing utilization needs of the customers. Our proposed features and their computational strategy exhibit reasonable precision performance to predict churn behavior in near future.