Miracle-dz/UniFAR-FTUs huggingface dataset:
Independência funcional e regresso ao domicílio: variável chave para a enfermagem de reabilitação

Introduction: Although aging is not synonymous with illness and dependency, the process enhances the progressive limitation of the capabilities of the individual to meet daily living activities independently, leading to greater need for informal and / or formal support. Objectives: To identify the extent to which socio demographic, clinical, housing and social support influence the functional independence of the elderly in return for their socio familiar environment. Method: We chose a triangulated methodology, following a descriptive–correlational route, using for this purpose a non-probabilistic sample for convenience, consisting of 50 patients admitted in Service Hospital S. Teotonio, E.P.E. Viseu and their caregivers. The measuring instrument used was a semi-structured interview and the Barthel Index. Results: The studied population is mostly male, with an average age of 73.7 years old, married, residing in rural areas. Their qualifications are the 1 st cycle of studies (four years of Primary School) and have a predominance of cerebrovascular diseases. Shows moderate dependence at discharge, preferably returning to their own home. The variables that significantly influenced the functional independence are: age, qualifications, place of residence after the internment, housing adaptation and formal support. Conclusions: Despite the limited relevance of the caregiver's profile, their absence or inability to care was predictive of institutionalization. This study could then be a further contribution in the development of awareness strategies / actions for the success of a plan of socio-familiar reintegration.
Biologically Plausible Modelling of Morality

Neural computation has an extraordinarily influential role in the study of several human capacities and behavior. It has been the dominant approach in the vision science of the last half century, and it is currently one of the fundamental methods of investigation for several higher cognitive functions. Yet, no neurocomputational models have been proposed for morality. Computational modeling in general has been scarcely pursued in morality, and existent non-neural attempts have failed to account for the mental processes involved during moral judgments. In this paper we argue that in the past decade the situation has evolved in a way that subverted the insu cient knowledge on the basic organization of moral cognition in brain circuits, making the project of modeling morality in neurocomputational terms feasible. We will sketch an original architecture that combines reinforcement learning and Hebbian learning, aimed at simulating forms of moral behavior in a simple artificial context.
Dexamethasone-Induced Prenatal Alveolar Wall Thinning Is Associated with a Decrease in EIIIA+ Fibronectin Isoform in the Fetal Rat Lung

Background: Glucocorticoid hormones play an important role in architectural and biochemical lung maturation. Although much of the molecular mechanism of their action in the lung is not fully understood, glucocorticoids directly or indirectly regulate lung maturation. Indirect effects of glucocorticoids may involve the modulation of cell-cell or cell-matrix interactions. Fibronectin (FN) is the major constituent of the pulmonary extracellular matrix and exists in multiple isoforms arising from alternative RNA splicing. EIIIA is the major alternatively spliced segment, and its expression is regulated in a spatiotemporal and oncodevelopmental manner. Objectives: The present study focuses on the regulation of EIIIA-containing FN isoforms (referred to as EIIIA+ FN) by glucocorticoids in the developing lung. Methods: Dexamethasone (DEX) or saline was injected daily into pregnant rats from day 15 of gestation (term = day 22) until 24 h before sacrifice. The expression of EIIIA+ FN and proliferating cell nuclear antigen (PCNA), a biochemical marker for cell proliferation, was investigated in the fetal rat lung. Results: At day 20 of gestation (the canalicular stage), the DEX-treated lung showed a significant decrease in weight and saccular septal wall thickness, while the messenger RNA expression of the surfactant protein SP-B was increased in the DEX-treated lung, as compared with the control lung. The expression of EIIIA+ FN and PCNA around the distal airspaces was less extensive in the DEX-treated lung than in the control lung at day 20 of gestation. Conclusions: Given the finding in vitro that EIIIA+ FN regulated the cell cycle, our results suggest that the change of EIIIA+ FN expression in the DEX-treated lung affected pulmonary cell proliferation.
Professional socialization in nursing: A qualitative content analysis

Background: Being a nurse is more than just a series of business activities and skills. In fact, it is a part of the process of socialization, which is internalization and development of professional identity. Professional socialization is necessary for involving the students in professional practices. Thus, the purpose of this qualitative research was to increase the understanding of professional socialization in nursing and explore the related factors from the perspective of registered nurses and nursing students. Materials and Methods: In this qualitative design, data were collected on 43 nurses with a variety of experiences using semi-structured interviews and focus groups in the Shiraz University of Medical Sciences in 2012. Data were analyzed through inductive content analysis. Results: The data analysis revealed two main categories: (1) sense of belonging with three sub-categories of theory-practice incongruence, educational experiences and tacit knowledge and (2) forming professional identity consisting of three sub-categories of relatedness, internal motivation and role model. Conclusions: This study demonstrates that in nursing, sense of belonging and professional identity contributes to professional socialization; it is suggested that these factors, which improve socialization in nurses, be taken into account by authorities.
Relationship satisfaction: the role of love styles and attachment styles

The current study used three adult attachment styles: secure, avoidant and anxious/resistant (Hazan and Shaver 1987) and six lovestyles: Eros, Ludus, Storge, Mania, Pragma and Agape (Lee 1973) to predict sexual and relationship satisfaction. The sample of 111 (64 women, 46 men, 1 sex unstated) were either currently or recently in a relationship of three months or more. Regressions to test a mediational model of sexual satisfaction on relationship satisfaction showed that the Eros lovestyle had a direct positive effect on relationship satisfaction and an indirect positive effect on relational satisfaction via sexual satisfaction, while Ludus and avoidant attachment both exhibited direct negative effects on relationship satisfaction, and indirect negative effects on relationship satisfaction via sexual satisfaction. [182] --------------[183]
Characterization of virus-like particles in GARDASIL® by cryo transmission electron microscopy

Cryo-transmission electron microscopy (cryoTEM) is a powerful characterization method for assessing the structural properties of biopharmaceutical nanoparticles, including Virus Like Particle-based vaccines. We demonstrate the method using the Human Papilloma Virus (HPV) VLPs in GARDASIL®. CryoTEM, coupled to automated data collection and analysis, was used to acquire images of the particles in their hydrated state, determine their morphological characteristics, and confirm the integrity of the particles when absorbed to aluminum adjuvant. In addition, we determined the three-dimensional structure of the VLPs, both alone and when interacting with neutralizing antibodies. Two modes of binding of two different neutralizing antibodies were apparent; for HPV type 11 saturated with H11.B2, 72 potential Fab binding sites were observed at the center of each capsomer, whereas for HPV 16 interacting with H16.V5, it appears that 60 pentamers (each neighboring 6 other pentamers) bind five Fabs per pentamer, for the total of 300 potential Fab binding sites per VLP.
PLP: Page Latch-free Shared-everything OLTP

Scaling the performance of shared-everything transaction processing systems to highly-parallel multicore hardware remains a challenge for database system designers. Recent proposals alleviate locking and logging bottlenecks in the system, leaving page latching as the next potential problem. To tackle the page latching problem, we propose physiological partitioning (PLP). The PLP design applies logical-only partitioning, maintaining the desired properties of shared-everything designs, and introduces a multi-rooted B+Tree index structure (MRBTree) which enables the partitioning of the accesses at the physical page level. Logical partitioning and MRBTrees together ensure that all accesses to a given index page come from a single thread and, hence, can be entirely latch-free; an extended design makes heap page accesses thread-private as well. Eliminating page latching allows us to simplify key code paths in the system such as B+Tree operations leading to more efficient and maintainable code. Profiling a prototype PLP system running on different multicore machines shows that it acquires 85% and 68% fewer contentious critical sections, respectively, than an optimized conventional design and one based on logical-only partitioning. PLP also improves performance up to 40% and 18%, respectively, over the existing systems.
Fatty liver disease in an autopsy series of children and adolescents.

BACKGROUND AND AIMS Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and adolescents. Obesity is a major risk factor for NAFLD; however, it has been shown that NAFLD is not rare in non-obese adults. The aim of this study was to determine the prevalence of NAFLD in obese and non-obese children and adolescents. METHODS The medical records of 340 subjects (aged 2-20 years) in whom autopsy was performed were retrospectively reviewed. Of those, 10 subjects were excluded due to insufficient data. The remaining 330 subjects were included in the study, of whom 264 were normal weight and 66 were obese. All liver biopsy sections were evaluated by two pathologists in a blinded fashion. RESULTS The prevalence of fatty liver was 6% among all the subjects and was higher in the overweight group than in the normal-weight group (10.6% vs 4.9%; p<0.001). The prevalence of NAFLD increased concomitant with age. There was no significant difference between sexes in cases with NAFLD. Simple steatosis was detected in 7 subjects. Steatohepatitis was determined as type 1 in 5 subjects, type 2 in 7 subjects, and as overlap in 1 subject. CONCLUSIONS This study demonstrated that NAFLD is an important public health problem not only in obese but also in non-obese children and adolescents. This suggests that whereas obesity may be a risk factor, other pathogenic factors may exist that could contribute to the NAFLD.
The work of imagination

Effluent gas containing SO2 and/or nitrogen oxides of various forms (referred to as NOx) are irradiated with an ionizing radiation to form aerosol. The aerosol is collected by a collecting means to form a collected material containing sulfur dioxide and nitrogen oxides. Effective components are recovered from the collected material by subjecting it either to steam-roasting with or without addition of ore of low grade, solid waste generated from smelting processes, copper-containing pyrite cinders or an alkali earth metal compound to the collected material, or to thermal decomposition.
Effects of stratospheric ozone recovery on photochemistry and ozone air quality in the troposphere

There has been significant stratospheric ozone de- pletion since the late 1970s due to ozone-depleting sub- stances (ODSs). With the implementation of the Montreal Protocol and its amendments and adjustments, stratospheric ozone is expected to recover towards its pre-1980 level in the coming decades. In this study, we examine the impli- cations of stratospheric ozone recovery for the tropospheric chemistry and ozone air quality with a global chemical trans- port model (GEOS-Chem). With a full recovery of the strato- spheric ozone, the projected increases in ozone column range from 1 % over the low latitudes to more than 10 % over the polar regions. The sensitivity factor of troposphere ozone photolysis rate, defined as the percentage changes in surface ozone photolysis rate for 1 % increase in stratospheric ozone column, shows significant seasonal variation but is always negative with absolute value larger than one. The expected stratospheric ozone recovery is found to affect the tropo- spheric ozone destruction rates much more than the ozone production rates. Significant decreases in surface ozone pho- tolysis rates due to stratospheric ozone recovery are sim- ulated. The global average tropospheric OH decreases by 1.7 %, and the global average lifetime of tropospheric ozone increases by 1.5 %. The perturbations to tropospheric ozone and surface ozone show large seasonal and spatial variations. General increases in surface ozone are calculated for each season, with increases by up to 0.8 ppbv in the remote areas. Increases in ozone lifetime by up to 13 % are found in the troposphere. The increased lifetimes of tropospheric ozone in response to stratospheric ozone recovery enhance the in- tercontinental transport of ozone and global pollution, in par- ticular for the summertime. The global background ozone at- tributable to Asian emissions is calculated to increase by up to 15 % or 0.3 ppbv in the Northern Hemisphere in response to the projected stratospheric ozone recovery.
Dosimetric Assessment of Simultaneous Exposure to ELF Electric and Magnetic Fields

In the low-frequency range, both electric and magnetic fields interact with biological tissue by inducing intracorporal electric current densities, although ruled by different physical laws and, hence, with different intracorporal orientation and pathways. Presently, standards require a separate assessment of electric and magnetic fields even in the case of simultaneous exposure and, hence, ignore the superposition of intracorporal current densities. Numerical simulations with the Visible Man model show that this can lead to underestimating current densities in the central nervous system (CNS) by up to 29%. While the superposed electric current densities in the CNS still meet the basic restrictions, the situation changes if a fetus with its own CNS requires the same level of protection. When the compliance volume is extended to the trunk, the reference-level electric-field exposure exceeds the basic restrictions by 38%. Depending on the kind of summation of the vectorial contributions, simultaneous exposure to the 50 Hz-5 kV/m electric field and 100-T magnetic field may lead to a 2.1-fold to 2.6-fold excess of the basic restriction. While this does not prove noncompliance, it indicates that fetal CNS exposure modeling is needed for clarification.
Macrophage Migration Inhibitory Factor Reduces the Growth of Virulent Mycobacterium tuberculosis in Human Macrophages

ABSTRACT Macrophage migration inhibitory factor (MIF) is a key mediator of the innate immune system and plays a crucial role in the host response to bacterial infections. Its role in immunity to intracellular pathogens has not been well studied. Here, we show that MIF released by infected human macrophages inhibits the growth of virulent Mycobacterium tuberculosis.
Generalized Relay Selection for Improved Security in Cooperative DF Relay Networks

In this letter, a generalized multi-relay selection scheme is proposed to improve the security in a cooperative relay network. Assuming that only the statistical channel state information of the eavesdropper is available at the transmitter, a semiclosed-form expression of the secrecy outage probability (SOP) is derived. Based on this, both the power allocation factor and the number of relay nodes are jointly optimized to minimize the SOP. Simulation results show that the proposed multi-relay selection scheme outperforms the conventional single-relay selection scheme without increasing the overhead.
First Nest Description for the Ocellated Antbird (Phaenostictus mcleannani)

Abstract We present the first description of a nest of the Ocellated Antbird (Phaenostictus mcleannani), an understory species that ranges from southeastern Honduras to northwestern Ecuador. The open-cup nest was found in June 2002, in the Republic of Panama, and was located on the leaf litter between the buttresses of a Virola surinamensis tree. The nest contained two ovoid, whitish eggs with reddish-brown speckles and longitudinal streaks.
Inflammation‐induced hepatocellular carcinoma is dependent on CCR5 in mice

Human hepatocellular carcinoma (HCC) is an inflammation‐induced cancer, which is the third‐leading cause of cancer mortality worldwide. We investigated the role of the chemokine receptors, CCR5 and CCR1, in regulating inflammation and tumorigenesis in an inflammation‐induced HCC model in mice. Multidrug resistance 2 gene (Mdr2)‐knockout (Mdr2‐KO) mice spontaneously develop chronic cholestatic hepatitis and fibrosis that is eventually followed by HCC. We generated two new strains from the Mdr2‐KO mouse, the Mdr2:CCR5 and the Mdr2:CCR1 double knockouts (DKOs), and set out to compare inflammation and tumorigenesis among these strains. We found that in Mdr2‐KO mice lacking the chemokine receptor, CCR5 (Mdr2:CCR5 DKO mice), but not CCR1 (Mdr2:CCR1 DKO), macrophage recruitment and trafficking to the liver was significantly reduced. Furthermore, in the absence of CCR5, reduced inflammation was also associated with reduced periductal accumulation of CD24+ oval cells and abrogation of fibrosis. DKO mice for Mdr2 and CCR5 exhibited a significant decrease in tumor incidence and size. Conclusions: Our results indicate that CCR5 has a critical role in both the development and progression of liver cancer. Therefore, we propose that a CCR5 antagonist can serve for HCC cancer prevention and treatment. (Hepatology 2013;53:1021–1030)
Restarting search algorithms with applications to simulated annealing

Some consequences of restarting stochastic search algorithms are studied. It is shown under reasonable conditions that restarting when certain patterns occur yields probabilities that the goal state has not been found by the nth epoch which converge to zero at least geometrically fast in n. These conditions are shown to hold for restarted simulated annealing employing a local generation matrix, a cooling schedule T n ∼ c/n and restarting after a fixed number r + 1 of duplications of energy levels of states when r is sufficiently large. For simulated annealing with logarithmic cooling these probabilities cannot decrease to zero this fast. Numerical comparisons between restarted simulated annealing and several modern variations on simulated annealing are also presented and in all cases the former performs better.
Trust In and Adoption of Online Recommendation Agents

Online product recommendation agents are becoming increasingly prevalent on a wide range of websites. These agents assist customers in reducing information overload, providing advice to find suitable products, and facilitating online decision-making. Consumer trust in recommendation agents is an integral factor influencing their successful adoption. However, the nature of trust in technological artifacts is still an under-investigated and not well understood topic. Online recommendation agents work on behalf of individual users (principals) by reflecting their specific needs and preferences. Trust issues associated with online recommendation agents are complicated. Users may be concerned about the competence of an agent to satisfy their needs as well as its integrity and benevolence in regard to acting on their behalf rather than on behalf of a web merchant or a manufacture. This study extends the interpersonal trust construct to trust in online recommendation agents and examines the nomological validity of trust in agents by testing an integrated Trust-TAM (Technology Acceptance Model). The results from a laboratory experiment confirm the nomological validity of trust in online recommendation agents. Consumers treat online recommendation agents as “social actors” and perceive human characteristics (e.g., benevolence and integrity) in computerized agents. Furthermore, the results confirm the validity of Trust-TAM to explain online recommendation acceptance and reveal the relative importance of consumers’ initial trust vis-a-vis other antecedents addressed by
Feature analysis of dysphonia speech for monitoring Parkinson's disease

Parkinson's disease (PD) is a progressive neurodegenerative disorder that has no known cure and no known prevention. Early detection is crucial in order to slow down the progress. In the past 10 years, interest in PD analysis has visibly increased. Speech impairment affects the majority of people with Parkinson's (PWP). New features and machine learning algorithms were proposed to help diagnose PD and to measure a patient's progress. Using sustained vowel /a/ recordings, we identified a more prominent set of Mel-Frequency Cepstral Coefficient (MFCC) and Intrinsic Mode Functions (IMF), and other parameters that can best represent the characteristics of Parkinson's dysphonia to assist with the diagnosis process. For higher quality audio signals, there is a visible difference in the higher MFCC coefficients, the wider spectrum bandwidth in the first four IMFs of PWP, and higher power intensity in the healthy subjects. We also found that even when the signals are downsampled into toll-quality, the distinguishable MFCC and IMF features were largely maintained. This enabled a whole possibility of providing telemedicine for PWP.
A COMPARATIVE STUDY OF SOME PRIORITY QUEUES SUITABLE FOR IMPLEMENTATION OF THE PENDING EVENT SET

Implementation of the pending event set (PES) is often crucial to the execution speed of a simulation. Parallel access implementation of the PES is a possible means of gaining performance improvement in discrete event simulation. In this paper a comparative study of some sequential and parallel access implementations of the PES is presented, these include linked lists, the Calendar Queue, the Lazy Queue, the Skew Heap and the implicit binary heap. All the parallel access implementations have a potential for an O(1) access time. A comparison of the performance of these implementations on a shared memory multiprocessor is presented. From these experiments some guide-lines have been compiled for choosing priority queue implementations for the PES. We also show that the parallel access implementations of the priority queues considered in this paper only offers what could be characterized as limited consitency. This fact may make these implementations less suitable for implementation of the PES in conservative simulators.