Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulation of herpes simplex virus type 1 thymidine kinase gene expression by thyroid hormone receptor in cultured neuronal cells

Herpes simplex virus type 1 (HSV-1) undergoes acute infection in epithelial cells followed by establishment of latency in the neurons of trigeminal ganglia. The latent virus maintains a dormant state and can recurs spontaneously, suggesting transcriptional silencing and reactivation occur in neurons. Computer data mining identified a nuclear hormone response element (NRE), the binding site for the thyroid hormone receptor (TR) or other nuclear hormone receptor, in the promoter of HSV-1 thymidine kinase (TK). TRs are transcription factors whose activity is dependent on their ligand thyroid hormone (T3; triiodothyronine). We hypothesize that TR and T3 exert regulation on HSV-1 gene expression in neurons. A neuroblastoma cell line expressing the TR isoform β (N2aTRβ) was utilized for in vitro investigation. Results showed that liganded TR repressed TK promoter activity but unliganded TR relieved the inhibition. The mutagenesis study demonstrated that one nucleotide mutation at the NRE abolished the T3/TR-mediated regulation. N2aTRβ cells treated with T3 were suppressive to TK expression and virus release but the removal of T3 de-repressed TK expression and increased virus release, confirmed by reverse transcriptase—polymerase chain reaction (RT-PCR) and plaque assays, respectively. Chromatin immunoprecipitation (ChIP) assays showed that TRs were enriched at TK NRE in the presence of T3. Additional results demonstrated that hyper acetylated histone H4 and monomethylated H3 modified at lysine 9 (H3K9me1) were enriched at transcriptionally active TK promoters but were dissociated from the NRE by T3/TR. These results suggest that T3 could regulate HSV-1 gene expression through its receptor via histone modification in cultured neuronal cells.
Business Ethics: New Perspectives on Old Problems

This article traces the historical roots of some of our current preoccupations with the ethics of business. It argues that many of the contemporary criteria that we use to evaluate the ethics of business are not new; rather, they date back several centuries. This argument is illustrated by comparing historical and contemporary discussions of three sets of issues: the relationship between ethics and profits, the relationship between private gain and the public good, and the tension between the results of capitalism and the intentions of businessmen. The fact that these tensions are inherent in the nature of capitalism, if not human nature itself, does not make our contemporary concerns or standards any less valid. On the contrary, it underlies their significance. Contemporary discussions of business ethics constitute part of an ongoing moral dialogue with both deep secular and religious roots.
Geriatric pharmacology and pharmacotherapy education for health professionals and students: a systematic review.

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT The rate of medication errors is high, and these errors can cause adverse drug reactions. Elderly individuals are most vulnerable to adverse drug reactions. One cause of medication errors is the lack of drug knowledge on the part of different health professionals. Medical curricula have changed in recent years, resulting in less education in the basic sciences, such as pharmacology. WHAT THIS STUDY ADDS Our study shows that little curricular time is devoted to geriatric pharmacology and that educational programmes in geriatric pharmacology have not been thoroughly evaluated. While interest in pharmacology education has increased recently, this is not the case for geriatric pharmacology education. Education on geriatric pharmacology should have more attention in the curricula of health professionals, given the often complex pharmacotherapy in elderly patients. Educational topics should be related to the known risk factors of medication errors, such as polypharmacy, dose adjustments in organ dysfunction and psychopharmacotherapeutics. AIMS Given the reported high rates of medication errors, especially in elderly patients, we hypothesized that current curricula do not devote enough time to the teaching of geriatric pharmacology. This review explores the quantity and nature of geriatric pharmacology education in undergraduate and postgraduate curricula for health professionals. METHODS Pubmed, Embase and PsycINFO databases were searched (from 1 January 2000 to 11 January 2011), using the terms 'pharmacology' and 'education' in combination. Articles describing content or evaluation of pharmacology education for health professionals were included. Education in general and geriatric pharmacology was compared. RESULTS Articles on general pharmacology education (252) and geriatric pharmacology education (39) were included. The number of publications on education in general pharmacology, but not geriatric pharmacology, has increased over the last 10 years. Articles on undergraduate and postgraduate education for 12 different health disciplines were identified. A median of 24 h (from 15 min to 4956 h) devoted to pharmacology education and 2 h (1-935 h) devoted to geriatric pharmacology were reported. Of the articles on education in geriatric pharmacology, 61.5% evaluated the teaching provided, mostly student satisfaction with the course. The strength of findings was low. Similar educational interventions were not identified, and evaluation studies were not replicated. CONCLUSIONS Recently, interest in pharmacology education has increased, possibly because of the high rate of medication errors and the recognized importance of evidence-based medical education. Nevertheless, courses on geriatric pharmacology have not been evaluated thoroughly and none can be recommended for use in training programmes. Suggestions for improvements in education in general and geriatric pharmacology are given.
FEMALE CHIEF ACADEMIC OFFICERS IN EVANGELICAL CHRISTIAN COLLEGES AND UNIVERSITIES: PART II: REFLECTIONS ON CAREERS, MARRIAGE, AND FAITH

This article is the second in a two-part series of case studies of sixteen female chief academic officers (CAO) serving in evangelical colleges and universities. The earlier article discussed each administrator's personal and academic background. This continues the reflections of these women regarding their careers, marital status and faith as factors that influenced their professional lives. The typical female administrator was 50, married, and the mother of one or more children. Although she had aspired to teach and received most of her early career experience in the professoriate, she had not aspired to be an administrator. Her family and professional roles were sometimes in conflict and required her to juggle her responsibilities. Regarding her spiritual convictions and personal disciplines, she adamantly believed both affected her daily work and personal life. The majority were appointed to their administrative positions. Only five reported applying for the position. A comparison needs to be made to determine if most men in these positions are appointed or apply, in order to describe if women are treated differently than men in the selection process for academic positions.
Hip hop am Main: the localization of rap music and hip hop culture

This article examines the way in which rap music and hip hop culture have been appropriated and reworked by the youth of Turkish and Moroccan communities in Frankfurt am Main, Germany. I begin by considering how, via the incorporation of German and Turkish lyrics into self-composed rap songs, Frankfurt rap groups have been able to turn the genre into a highly localized mode of expression. More specifically, such a reworking of the rap genre has enabled its use as a medium for the voicing of issues relating to the problems of racism and citizenship with which ethnic minority groups newly or recently settled in Germany are faced. In the second part of the article I consider some of the resources which Frankfurt rappers have been able to draw upon in their attempts to rework hip hop as a localized mode of expression.
The Relationship of Education to Blood Pressure: Findings on 40,000 Employed Chicagoans

SUMMARY The relationship of education to both actual blood pressure and the prevalence of high blood pressure, based on a systolic pressure of 160 mm Hg or greater or a diastolic pressure of 95 mm Hg or greater, was analyzed among 27,033 men and women, white and black, age 25–44 and 45–64, from the Chicago Heart Association Detection Project in Industry. The educational status of each individual was categorized as not a high school graduate, high school graduate, some college, or college graduate. A statistically significant inverse association between education and high blood pressure was present in all groups of whites. This association could not be “accounted for” by differences in age, relative weight, and heart rate among the educational strata. Controlling for these variables did, however, lessen the association. Among black males a significant inverse association between education level and blood pressure was found for the younger group. For the older black males there was a clear inverse association although with the small numbers it did not achieve statistical significance. For black females there was no clear association.
Postnatal depression, maternal–infant bonding and social support: a cross-cultural comparison of Nigerian and British mothers

Abstract Objectives: The high prevalence of Post-Natal Depression (PND) in low and lower-middle income countries of Africa raises questions about the functionality of the abundant informal support accessed in the enmeshed family structure. This study examined the interaction between social support, parity and culture in the development of PND and maternal–infant bonding (MIB) among Nigerian, British and Nigerian Immigrant mothers in the UK. Methods: Participants (N = 124) were recruited from the UK and Nigeria via local support groups for mothers, websites offering motherhood-related content and social media. Questionnaires including the Edinburgh Postnatal Depression Scale (EPDS), Postpartum Bonding Questionnaire and Norbeck's Social Support Questionnaire were uploaded onto SurveyMonkey®. Results: Findings revealed significant cultural differences in PND and social support. Multiple regression analyses revealed that PND, social support and culture could predict MIB, with PND being the only significant independent predictor. Conclusions: Our findings highlight the importance that cultural factors play in the development of PND and the establishment of MIB in the context of culturally attuned healthcare services.
Hypoxia Downregulates MAPK/ERK but Not STAT3 Signaling in ROS-Dependent and HIF-1-Independent Manners in Mouse Embryonic Stem Cells

Hypoxia is involved in the regulation of stem cell fate, and hypoxia-inducible factor 1 (HIF-1) is the master regulator of hypoxic response. Here, we focus on the effect of hypoxia on intracellular signaling pathways responsible for mouse embryonic stem (ES) cell maintenance. We employed wild-type and HIF-1α-deficient ES cells to investigate hypoxic response in the ERK, Akt, and STAT3 pathways. Cultivation in 1% O2 for 24 h resulted in the strong dephosphorylation of ERK and its upstream kinases and to a lesser extent of Akt in an HIF-1-independent manner, while STAT3 phosphorylation remained unaffected. Downregulation of ERK could not be mimicked either by pharmacologically induced hypoxia or by the overexpression. Dual-specificity phosphatases (DUSP) 1, 5, and 6 are hypoxia-sensitive MAPK-specific phosphatases involved in ERK downregulation, and protein phosphatase 2A (PP2A) regulates both ERK and Akt. However, combining multiple approaches, we revealed the limited significance of DUSPs and PP2A in the hypoxia-mediated attenuation of ERK signaling. Interestingly, we observed a decreased reactive oxygen species (ROS) level in hypoxia and a similar phosphorylation pattern for ERK when the cells were supplemented with glutathione. Therefore, we suggest a potential role for the ROS-dependent attenuation of ERK signaling in hypoxia, without the involvement of HIF-1.
An exploratory study of grandparents raising grandchildren and the criminal justice system: a research note

There are nearly one million grandparents living with their grandchildren without either parent present in the household according to the 2010 US Census. Furthermore, approximately 10% of these grandparents are the primary caregivers of their grandchildren due to a parent's incarceration. Yet, our understanding of grandparents raising grandchildren in relation to the criminal justice system is limited. The present research is an exploratory qualitative study of five grandparents raising grandchildren in these circumstances. Each grandparent was interviewed individually and all participated in a focus group. We first sought to shed light on the context in which the grandparent gained caregiving responsibilities. The findings indicate that the arrest of the parent was not the initiating event. We then examined the networks and services accessed when attempting to meet the multiple health, behavioral health, and financial needs of their grandchildren. Findings indicate that both formal and informal networks were utilized. There were several missed opportunities for intervention and coordinated service delivery by the social services and criminal justice systems. Research and policy implications are also discussed.
Patient Compliance to Psychiatric Interventions and Course of Postpartum Mood Disorders

Objective: Patient compliance to the psychiatric interventions may affect the outcomes of the mothers with postpartum mood disorders. The aim of this study was to assess the course of depressive symptoms of compliant and noncompliant mothers with postpartum mood disorders. Method: One hundred-three mothers were followed with the Edinburgh Postnatal Depression Scale (EPDS) during 12-month follow-up period. Mothers with an EPDS score of 12 or higher were consulted with a psychiatrist. “Noncompliant patient” term was defined in this study for the patients who refused psychiatric consultation or treatment suggestions. Outcomes of the depressive symptoms were followed up according to the EPDS scores. Response rate based EPDS scoring was defined. Results: A total of 35 (34%) mothers received a higher EPDS score;28 (27.2%), who accepted the consultation, were diagnosed with postpartum mood disorder. Twenty-three mothers (10 mothers with major depressive disorder and 13 mothers with adjustment disorder) complied with treatment suggestions, and all of them responded to the treatment. EPDS scores was more likely to decrease in these compliant mothers (p = 0.010). However, of the noncompliant mothers (n=12), only 50% responded to treatment; moreover, the drop out rate was quite high (58.3%). Conclusions: This study reveals that noncompliance to psychiatric interventions may lead to a much less favorable course in depressive symptoms, and to a tendency in drop-outs from visits. Health professionals can give advice to the mothers about postpartum mood disorders and could assist them in getting better outcome.
Rubik: Unlocking the Power of Locality and End-point Flexibility in Cloud Scale Load Balancing

Cloud scale load balancers, such as Ananta and Duet are critical components of the data center (DC) infrastructure, and are vital to the performance of the hosted online services. In this paper, using traffic traces from a production DC, we show that prior load balancer designs incur substantial overhead in the DC network bandwidth usage, due to the intrinsic nature of traffic redirection. Moreover, in Duet, traffic redirection results in extra bandwidth consumption in the core network and breaks the full-bisection bandwidth guarantees offered by the underlying networks such as Clos and FatTree. We present RUBIK, a load balancer that significantly lowers the DC network bandwidth usage while providing all the performance and availability benefits of Duet. RUBIK achieves its goals by applying two principles in the scale-out load balancer design - exploiting locality and applying end-point flexibility in placing the servers. We show how to jointly exploit these two principles to maximally contain the traffic load balanced to be within individual ToRs while satisfying service-specific failure domain constraints. Our evaluation using a testbed prototype and DC-scale simulation using real traffic traces shows that compared to the prior art Duet, RUBIK can reduce the bandwidth usage by over 3× and the maximum link utilization of the DC network by 4×, while providing all the performance, scalability, and availability benefits.
The Curious Case of Metonymic Verbs: A Distributional Characterization

Logical metonymy combines an event-selecting verb with an entity-denoting noun (e.g., The writer began the novel), triggering a covert event interpretation (e.g., reading, writing). Experimental investigations of logical metonymy must assume a binary distinction between metonymic (i.e. eventselecting) verbs and non-metonymic verbs to establish a control condition. However, this binary distinction (whether a verb is metonymic or not) is mostly made on intuitive grounds, which introduces a potential confounding factor. We describe a corpus-based approach which characterizes verbs in terms of their behavior at the syntax-semantics interface. The model assesses the extent to which transitive verbs prefer event-denoting objects over entity-denoting objects. We then test this “eventhood” measure on psycholinguistic datasets, showing that it can distinguish not only metonymic from non-metonymic verbs, but that it can also capture more fine-grained distinctions among different classes of metonymic verbs, putting such distinctions into a new graded perspective.
PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesis

Candida albicans, like many fungi, exhibits morphological plasticity, a property which may be related to its biological capacity as an opportunistic pathogen of humans. Morphogenesis and alterations in cell shape require integration of many cellular functions and occur in response to environmental signals, most notably pH and temperature in the case of C. albicans. In the course of our studies of differential gene expression associated with dimorphism of C. albicans, we have isolated a gene, designated PHR1, which is regulated in response to the pH of the culture medium. PHR1 expression was repressed at pH values below 5.5 and induced at more alkaline pH. The predicted amino acid sequence of the PHR1 protein was 56% identical to that of the Saccharomyces cerevisiae Ggp1/Gas1 protein, a highly glycosylated cell surface protein attached to the membrane via glycosylphosphatidylinositol. A homozygous null mutant of PHR1 was constructed and found to exhibit a pH-conditional morphological defect. At alkaline pH, the mutant, unlike the parental type, was unable to conduct apical growth of either yeast or hyphal growth forms. This morphological aberration was not associated with defective cytoskeletal polarization or secretion. The results suggest that PHR1 defines a novel function required for apical cell growth and morphogenesis.
Layered pattern receptor signaling via ethylene and endogenous elicitor peptides during Arabidopsis immunity to bacterial infection

Recognition of molecular patterns characteristic of microbes or altered-self leads to immune activation in multicellular eukaryotes. In Arabidopsis thaliana, the leucine-rich-repeat receptor kinases FLAGELLIN-SENSING2 (FLS2) and EF-TU RECEPTOR (EFR) recognize bacterial flagellin and elongation factor EF-Tu (and their elicitor-active epitopes flg22 and elf18), respectively. Likewise, PEP1 RECEPTOR1 (PEPR1) and PEPR2 recognize the elicitor-active Pep epitopes conserved in Arabidopsis ELICITOR PEPTIDE PRECURSORs (PROPEPs). Here we reveal that loss of ETHYLENE-INSENSITIVE2 (EIN2), a master signaling regulator of the phytohormone ethylene (ET), lowers sensitivity to both elf18 and flg22 in different defense-related outputs. Remarkably, in contrast to a large decrease in FLS2 expression, EFR expression and receptor accumulation remain unaffected in ein2 plants. Genome-wide transcriptome profiling has uncovered an inventory of EIN2-dependent and EFR-regulated genes. This dataset highlights important aspects of how ET modulates EFR-triggered immunity: the potentiation of salicylate-based immunity and the repression of a jasmonate-related branch. EFR requires ET signaling components for PROPEP2 activation but not for PROPEP3 activation, pointing to both ET-dependent and -independent engagement of the PEPR pathway during EFR-triggered immunity. Moreover, PEPR activation compensates the ein2 defects for a subset of EFR-regulated genes. Accordingly, ein2 pepr1 pepr2 plants exhibit additive defects in EFR-triggered antibacterial immunity, compared with ein2 or pepr1 pepr2 plants. Our findings suggest that the PEPR pathway not only mediates ET signaling but also compensates for its absence in enhancing plant immunity.
The Microscope and the Moving Target: The Challenge of Applying Content Analysis to the World Wide Web

Analysis of nineteen studies that apply content analysis techniques to the World Wide Web found that this stable research technique can be applied to a dynamic environment. However, the rapid growth and change of Web-based content present some unique challenges. Nevertheless, researchers are now using content analysis to examine themes such as diversity, commercialization, and utilization of technology on the World Wide Web. Suggestions are offered for how researchers can apply content analysis to the Web with primary focus on formulating research questions/hypotheses, sampling, data collection and coding, training/reliability of coders, and analyzing/interpreting data.
An Instance-Based Algorithm With Auxiliary Similarity Information for the Estimation of Gait Kinematics From Wearable Sensors

Wearable human movement measurement systems are increasingly popular as a means of capturing human movement data in real-world situations. Previous work has attempted to estimate segment kinematics during walking from foot acceleration and angular velocity data. In this paper, we propose a novel neural network [GRNN with Auxiliary Similarity Information (GASI)] that estimates joint kinematics by taking account of proximity and gait trajectory slope information through adaptive weighting. Furthermore, multiple kernel bandwidth parameters are used that can adapt to the local data density. To demonstrate the value of the GASI algorithm, hip, knee, and ankle joint motions are estimated from acceleration and angular velocity data for the foot and shank, collected using commercially available wearable sensors. Reference hip, knee, and ankle kinematic data were obtained using externally mounted reflective markers and infrared cameras for subjects while they walked at different speeds. The results provide further evidence that a neural net approach to the estimation of joint kinematics is feasible and shows promise, but other practical issues must be addressed before this approach is mature enough for clinical implementation. Furthermore, they demonstrate the utility of the new GASI algorithm for making estimates from continuous periodic data that include noise and a significant level of variability.