Miracle-dz/UniFAR-FTUs huggingface dataset:
Immediate Implant-based Prepectoral Breast Reconstruction Using a Vertical Incision

Background: Ideally, breast reconstruction is performed at the time of mastectomy in a single stage with minimal scarring. However, postoperative complications with direct-to-implant subpectoral reconstruction remain significant. These include asymmetry, flap necrosis, animation deformity, and discomfort. We report on a series of patients who have undergone immediate single-stage prepectoral, implant-based breast reconstruction with a smooth, adjustable saline implant covered with mesh/acellular dermal matrix for support using a vertical mastectomy incision. This technique, when combined with an adjustable implant, addresses the complications related to subpectoral implant placement of traditional expanders. Our follow-up time, 4.6 years (55 months), shows a low risk of implant loss and elimination of animation deformity while also providing patients with a safe and aesthetically pleasing result. Methods: All patients who underwent immediate implant-based prepectoral breast reconstruction using a vertical mastectomy incision as a single-staged procedure were included. Charts were reviewed retrospectively. Adjustable smooth round saline implants and mesh/acellular dermal matrix were used for fixation in all cases. Results: Thirty-one patients (62 breasts) underwent single-staged implant-based prepectoral breast reconstruction using a vertical mastectomy incision. Postoperative complications occurred in 9 patients, 6 of which were resolved with postoperative intervention while only 2 cases resulted in implant loss. Conclusions: There can be significant morbidity associated with traditional subpectoral implant-based breast reconstruction. As an alternative, the results of this study show that an immediate single-stage prepectoral breast reconstruction with a smooth saline adjustable implant, using a vertical incision, in conjunction with mesh/matrix support can be performed with excellent aesthetic outcomes and minimal complications.
Duality cascades and duality walls

We recast the phenomenon of duality cascades in terms of the Cartan matrix associated to the quiver gauge theories appearing in the cascade. In this language, Seiberg dualities for the different gauge factors correspond to Weyl reflections. We argue that the UV behavior of different duality cascades depends markedly on whether the Cartan matrix is affine ADE or not. In particular, we find examples of duality cascades that can't be continued after a finite energy scale, reaching a ``duality wall'', in terminology due to M. Strassler. For these duality cascades we suggest the existence of a UV completion in terms of a little string theory.
Effect of body composition on bone mineral density in Moroccan patients with juvenile idiopathic arthritis

Introduction The link between bone mass and body composition is widely recognized, but only few works were selectively performed on subjects with juvenile idiopathic arthritis. The aim of our study was to investigate the effect of body composition on bone mineral density (BMD) in Moroccan patients with juvenile idiopathic arthritis. Methods Thirty three children with juvenile idiopathic arthritis (JIA) were included in a cross-sectional study. The diagnosis of JIA was made according to the criteria of the International League of Association of Rheumatology (ILAR). Body mass index (BMI) was calculated from the ratio of weight/height2(kg/m2). Pubertal status was determined according to the Tanner criteria. Bone status, body composition and bone mineral content (BMC) were analyzed by using dual-energy X-ray absorptiometry (DXA). BMD was assessed at the lumbar spine (L1-L4) and at total body in (g/cm2). Total body fat tissue mass (FTM) and lean tissue mass (LTM) were also analyzed by DXA and expressed in kilograms. In children, low BMD was defined as a Z-score less than -2 and osteoporosis was defined as a Z-score less than -2 with a fracture history. Results A cross-sectional study was conducted in 33 Moroccan patients with JIA aged between 4 and 16 years, Fat mass was not related to bone density; in contrast, BMD was positively associated to LTM in total body(r = =0.41, p= 0.04) but not in lumbar spine (r = 0.29, p= 0.17). There exist significant correlation between BMC and BMD in total body (r = 0.51, p = 0.01). Conclusion This study suggests that the LTM is a determining factor of the BMD during adolescence. Other studies with a broader sample would be useful to confirm this relation.
Simulation and Prediction of Category 4 and 5 Hurricanes in the High-Resolution GFDL HiFLOR Coupled Climate Model

AbstractA new high-resolution Geophysical Fluid Dynamics Laboratory (GFDL) coupled model [the High-Resolution Forecast-Oriented Low Ocean Resolution (FLOR) model (HiFLOR)] has been developed and used to investigate potential skill in simulation and prediction of tropical cyclone (TC) activity. HiFLOR comprises high-resolution (~25-km mesh) atmosphere and land components and a more moderate-resolution (~100-km mesh) sea ice and ocean component. HiFLOR was developed from FLOR by decreasing the horizontal grid spacing of the atmospheric component from 50 to 25 km, while leaving most of the subgrid-scale physical parameterizations unchanged. Compared with FLOR, HiFLOR yields a more realistic simulation of the structure, global distribution, and seasonal and interannual variations of TCs, as well as a comparable simulation of storm-induced cold wakes and TC-genesis modulation induced by the Madden–Julian oscillation (MJO). Moreover, HiFLOR is able to simulate and predict extremely intense TCs (Saffir–Simpson h.
Dose‐dependent increases in p70S6K phosphorylation and intramuscular branched‐chain amino acids in older men following resistance exercise and protein intake

Resistance exercise and whey protein supplementation are effective strategies to activate muscle cell anabolic signaling and ultimately promote increases in muscle mass and strength. In the current study, 46 healthy older men aged 60–75 (69.0 ± 0.55 years, 85.9 ± 1.8 kg, 176.8 ± 1.0 cm) performed a single bout of unaccustomed lower body resistance exercise immediately followed by ingestion of a noncaloric placebo beverage or supplement containing 10, 20, 30, or 40 g of whey protein concentrate (WPC). Intramuscular amino acid levels in muscle biopsy samples were measured by Gas Chromatography–Mass Spectrometry (GC‐MS) at baseline (before exercise and WPC supplementation) plus at 2 h and 4 h post exercise. Additionally, the extent of p70S6K phosphorylation at Thr389 in muscle biopsy homogenates was assessed by western blot. Resistance exercise alone reduced intramuscular branch chain amino acid (BCAA; leucine, isoleucine, and valine) content. Supplementation with increasing doses of whey protein prevented this fall in muscle BCAAs during postexercise recovery and larger doses (30 g and 40 g) significantly augmented postexercise muscle BCAA content above that observed following placebo ingestion. Additionally, the fold change in the phosphorylation of p70S6K (Thr389) at 2 h post exercise was correlated with the dose of whey protein consumed (r = 0.51, P < 001) and was found to be significantly correlated with intramuscular leucine content (r = 0.32, P = 0.026). Intramuscular BCAAs, and leucine in particular, appear to be important regulators of anabolic signaling in aged human muscle during postexercise recovery via reversal of exercise‐induced declines in intramuscular BCAAs.
Substantially increased faecal carriage of vancomycin-resistant enterococci in a tertiary Greek hospital after a 4 year time interval.

OBJECTIVES In a tertiary Greek hospital with no documented vancomycin-resistant enterococci (VRE) infections, a cross-sectional study was conducted in order to determine the degree of VRE faecal carriage among adult patients hospitalized in high-risk units. METHODS Specimens for the surveillance were collected from separate patients in two periods (January-May 1999 and January-May 2003); 258 specimens were submitted during the first period and 149 during the second period. RESULTS Three patients (1.2%) were colonized with VRE during the first period, whereas 52 (34.9%) were colonized during the second period. Two VRE isolates of the first period were Enterococcus faecalis and one Enterococcus faecium, whereas those of the second period were E. faecium except for three E. faecalis and two Enterococcus gallinarum. All VRE isolates apart from the two E. gallinarum isolates were positive for the vanA gene. The 48 vancomycin-resistant E. faecium were classified into eight clonal types, one of those predominating with 29 isolates; the remaining included one to nine isolates. The five vancomycin-resistant E. faecalis formed four distinct clonal types. CONCLUSIONS The study reports a substantially higher prevalence of VRE carriage when the surveillance was repeated after a 4 year time interval. Urgent infection control measures are needed to prevent emergence of VRE outbreaks in our hospital setting.
Changes in intensity of neurotic symptoms associated with reduction of suicidal ideation in patients who underwent psychotherapy in the day hospital for the treatment of neurotic and behavioral disorders.

OBJECTIVES Analysis of associations between changes in the intensity of neurotic symptoms and reduction of suicidal ideation (SI) or lack of SI reduction, in patients who underwent a course of intensive psychotherapy conducted in integrative approach with predominance of psychodynamic approach in a day hospital. METHODS Symptom Checklist KO"O" and Life Inventory completed by 461 women and 219 men treated in the psychotherapeutic day hospital due to neurotic, behavioral or personality disorders between 2005-2013. During the qualification for the therapy 134 women and 80 men reported SI, of whom 84.3% and 77.5% respectively improved. RESULTS The reduction of neurotic symptoms intensity was greater in patients of both genders who improved in terms of SI than in those who did not. This referred to global intensity of neurotic symptoms (OWK coefficient) in both genders (p<0.001), as well as to the majority of the neurotic symptoms subtypes in both genders (p<0.05): Phobic disorders, Other anxiety disorders, Obsessive-compulsive disorders, Conversions and dissociations, Autonomic disorders, Somatization disorders, Neurasthenia, Avoidance and dependence, Sexual dysfunctions, Dysthymia; and in case of women (p<0.05): Hypochondriasis, Depersonalization and derealization, Impulsiveness and histrionism and Non-organic sleep disorders. CONCLUSIONS The results show effectiveness and comprehensiveness of intensive psychotherapy as a treatment method that leads to improvement in terms of both SI and neurotic symptoms. This suggests that the applied therapy may be effective in preventing suicidality in this group of patients. The observed associations also point in favor of hypothesis on similarities in etiopathogenesis of and partly identical personality-related factors predisposing to SI and neurotic disorders.
Visual Localization Methods for Mars Roversusing Lander , Rover , and Descent

Mars rover sample return missions will require rover localization on scales ranging from under a meter near landers and sample caches, to 10's of meters for local exploration, to 100's of meters for long range exploration. A variety of technologies may contribute to rover localization, but at present there is no concretely deened localization architecture that covers all of these scales. This paper surveys approaches to visual localization using overhead and ground-level imagery and discusses particular capabilities under development at JPL. We conclude that visual localization is (1) reasonably well understood at the smallest scale, where mapping is done with mast-mounted cameras on the lander or rover, (2) reasonably promising at intermediate scales, where mapping is done with descent imagery, and (3) of uncertain potential for the largest scales, where mapping is done from orbit, due to lack of orbital imagery with adequate resolution. This suggests that the largest scales be addressed either with other sensors or by planning for additional, high resolution imaging, especially in stereo, in the area of traverse.
Numerical simulation of a bifurcating jet within a radially confined domain

Direct Numerical Simulation is used to model the discharge of a periodically perturbed jet of fluid into a pipe that is five times the diameter of the jet. A planar flapping perturbation at the jet inlet, when used on its own or when combined with an axisymmetric perturbation, leads to a bifurcation of the jet some distance downstream. The present observations help resolve a previous discrepancy between experimental and numerical results concerning the presence of this bifurcation phenomenon. Across all periods of perturbation, the bifurcation is strongest, and occurs closer to the jet inlet, when the flapping perturbation is used exclusively. For both single mode and bimodal perturbation, bifurcation is observed across Strouhal numbers (the ratio of the product of the inlet diameter and axial perturbation frequency to the inlet bulk speed) in the range 0.33–1. This is an expansion of the previously reported range for which this phenomenon has been observed.
On the Extension of Multidimensional Speckle Noise Model From Single-Look to Multilook SAR Imagery

Speckle noise represents one of the major problems when synthetic aperture radar (SAR) data are considered. Despite the fact that speckle is caused by the scattering process itself, it must be considered as a noise source due to the complexity of the scattering process. The presence of speckle makes data interpretation difficult, but it also affects the quantitative retrieval of physical parameters. In the case of one-dimensional SAR systems, speckle is completely determined by a multiplicative noise component. Nevertheless, for multidimensional SAR systems, speckle results from the combination of multiplicative and additive noise components. This model has been first developed for single-look data. The objective of this paper is to extend the single-look data model to define a multilook multidimensional speckle noise model. The asymptotic analysis of this extension, for a large number of averaged samples, is also considered to assess the model properties. Details and validation of the multilook multidimensional speckle noise model are provided both theoretically and by means of experimental SAR data acquired by the experimental synthetic aperture radar system, operated by the German Aerospace Center
Pengaruh Persepsi Risiko terhadap Minat Beli Online dengan Kepercayaan sebagai Variabel Mediasi (Studi pada Konsumen KoreaBuys.com)

This research tries to identify the direct and indirect influence of perceived risk on online purchase intention of customers of KoreanBuys.com mediated by trust. This explanatory research explains the causal relationship between the variables through hypothesis testing. Using non-probability sampling technique with the criteria of people who are at least 17 years of age and people who know and have accessed KoreaBuys.com, 130 people were selected as the respondents. The hypotheses were assessed using t test and Sobel test. The data were analyzed through Partial Least Squares (PLS) using SmartPLS 3.0. The results of the hypothesis testing show that perceived risk negatively and significantly affects trust, that perceived risk negatively and significantly affects online purchase intention, that trust positively and significantly affects online purchase intention, and that perceived risk positively and significantly affects online purchase intention mediated by trust. Keywords: perceived risk, online purchase intention, trust
Effect of Hearing Loss on Peer Victimization in School-Age Children

Nearly one third of school-age children report being bullied, primarily enduring teasing or rumors. Children with hearing loss (HL) are at increased risk of victimization due to being “different” from the general population. This project assesses effects of auditory status on bullying by comparing incidence and type of bullying in 87 youth and adolescents with HL (7–18 years) to published national data from peers in the general population. All participants wore auditory technology (i.e., hearing aids or cochlear implants), communicated orally, and participated in mainstream education. Each participant completed the 2009 National Crime Victimization Survey’s School Crime Supplement. Adolescents with HL endured significantly higher incidence of bullying versus the general population (50.0% vs. 28.0%), particularly for exclusion (26.3% vs. 4.7%) and coercion (17.5% vs. 3.6%). Children younger than 12 years with HL report lower rates of bullying (38.7%) than adolescents with HL, but rates did not differ significantly. Future research should explore risk and protective factors for peer victimization in youth and adolescents with HL to reduce long-term consequences on quality of life.
Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy.

BACKGROUND A 6-week double-blind, randomized, placebo-controlled trial was conducted to determine the efficacy of combined therapy with olanzapine and either valproate or lithium compared with valproate or lithium alone in treating acute manic or mixed bipolar episodes. METHODS The primary objective was to evaluate the efficacy of olanzapine (5-20 mg/d) vs placebo when added to ongoing mood-stabilizer therapy as measured by reductions in Young Mania Rating Scale (YMRS) scores. Patients with bipolar disorder (n = 344), manic or mixed episode, who were inadequately responsive to more than 2 weeks of lithium or valproate therapy, were randomized to receive cotherapy (olanzapine + mood-stabilizer) or monotherapy (placebo + mood-stabilizer). RESULTS Olanzapine cotherapy improved patients' YMRS total scores significantly more than monotherapy (-13.11 vs -9.10; P = .003). Clinical response rates (> or = 50% improvement on YMRS) were significantly higher with cotherapy (67.7% vs 44.7%; P< .001). Olanzapine cotherapy improved 21-item Hamilton Depression Rating Scale (HAMD-21) total scores significantly more than monotherapy (4.98 vs 0.89 points; P< .001). In patients with mixed-episodes with moderate to severe depressive symptoms (DSM-IV mixed episode; HAMD-21 score of > or = 20 at baseline), olanzapine cotherapy improved HAMD-21 scores by 10.31 points compared with 1.57 for monotherapy (P< .001). Extrapyramidal symptoms (Simpson-Angus Scale, Barnes Akathisia Scale, Abnormal Involuntary Movement Scale) were not significantly changed from baseline to end point in either treatment group. Treatment-emergent symptoms that were significantly higher for the olanzapine cotherapy group included somnolence, dry mouth, weight gain, increased appetite, tremor, and slurred speech. CONCLUSION Compared with the use of valproate or lithium alone, the addition of olanzapine provided superior efficacy in the treatment of manic and mixed bipolar episodes.
Deep ACS Imaging in the Globular Cluster NGC6397: Dynamical Models

We present N-body models to complement deep imaging of the metal-poor core-collapsed cluster NGC6397 obtained with the Hubble Space Telescope. All simulations include stellar and binary evolution in-step with the stellar dynamics and account for the tidal field of the Galaxy. We focus on the results of a simulation that began with 100000 objects (stars and binaries), 5% primordial binaries and Population II metallicity. After 16 Gyr of evolution the model cluster has about 20% of the stars remaining and has reached core-collapse. We compare the color-magnitude diagrams of the model at this age for the central region and an outer region corresponding to the observed field of NGC6397 (about 2-3 half-light radii from the cluster centre). This demonstrates that the white dwarf population in the outer region has suffered little modification from dynamical processes - contamination of the luminosity function by binaries and white dwarfs with non-standard evolution histories is minimal and should not significantly affect measurement of the cluster age. We also show that the binary fraction of main-sequence stars observed in the NGC6397 field can be taken as representative of the primordial binary fraction of the cluster. For the mass function of the main-sequence stars we find that although this has been altered significantly by dynamics over the cluster lifetime, especially in the central and outer regions, that the position of the observed field is close to optimal for recovering the initial mass function of the cluster stars (below the current turn-off mass). More generally we look at how the mass function changes with radius in a dynamically evolved stellar cluster and suggest where the best radial position to observe the initial mass function is for clusters of any age.
Estrogen receptor b 1 exerts antitum oral effects on SKOV-3 ovarian cancer cells

Estrogen receptor (ER) b1 and its splice variants are expressed both in ovary and ovarian cancer. We studied the role of ERb1 and two of its splice variants in regulation of gene expression, cellular proliferation, apoptosis, and migration of an ovarian cancer cell line. In this study, we transfected SK-OV-3 ovarian cancer cells with vectors coding for ERb1 or its splice variants ERb-d125 and ERb-d1256, and tested their response to estrogen and tamoxifen in comparison with the untransfected cells. Heterologous expression of ERb1, but not of the exon-deleted ERb variants resulted in notably slower cell growth of SK-OV-3 ovarian cancer cells, an effect Journal of Endocrinology (2007) 193, 421–433 0022–0795/07/0193–421 q 2007 Society for Endocrinology Printed in Great accompanied by more than tenfold increase of cyclindependent kinase inhibitor p21(WAF1) transcript levels and a significant reduction of cyclin A2 mRNA levels. SK-OV-3 cells stably overexpressing ERb1 ligand independently also exhibited an increased apoptosis rate and a significantly decreased motility, an effect accompanied by upregulation of fibulin 1c. Our data demonstrate that ERb1, but not the exon-deleted isoforms tested exerts multiple antitumoral effects on SK-OV-3 ovarian cancer cells even in the absence of estradiol or functional ERa. Journal of Endocrinology (2007) 193, 421–433
Performance of QuantiFERON-TB Gold In-Tube test and Tuberculin Skin Test for diagnosis of latent tuberculosis infection in BCG vaccinated health care workers

Background Tuberculin skin test (TST) has been used for years as an aid in diagnosing latent tuberculosis infection (LTBI) but it suffers from a number of well-documented performance and logistic problems. Quantiferon-TB Gold In Tube test (QFT-GIT) has been reported to have better sensitivity and specifity than TST. In this study, it was aimed to compare the performance of a commercial IFN-γ release assay (QFT-GIT) with TST in the diagnosis of HCWs at risk for latent TB infection in BCG vaccinated population. Material/Methods Hundred healthy volunteer health care workers were enrolled. All were subjected to TST and QFT-GIT. Results were compared among Health Care Workers (HCWs) groups in terms of profession, workplace, working duration. Results TST is affected by previous BCG vaccinations and number of cases with QFT-GIT positivity is increased in accordance with the TST induration diameter range. QFT-GIT result was negative in 17 of 32 TST positive (≥15 mm) cases and positive in 4 of 61 cases whose TST diameters are between 6–14 mm, that is attritutable to previous BCG vaccination(s). It was negative in all cases with TST diameters between 0–5 mm. HCWs with positive QFT-GIT results were significantly older than the ones with negative results. Furthermore duration of work was significantly longer in QFT-GIT positive than in negative HCWs. Conclusions There was a moderate concordance between QFT-GIT and TST, when TST result was defined as positive with a ≥15 mm diameter of induration. We suggest that QFT-GIT can be used as an alternative to TST for detection of LTBI, especially in groups with high risk of LTBI and in population with routine BCG vaccination program.