Miracle-dz/UniFAR-FTUs huggingface dataset:
Flame retardant treated flax fibre reinforced phenolic composites: Ageing and thermal characteristics

In this study, flax composites were prepared from flax fabric and phenolic resin. Chemical treatments were imparted to the fabric to improve adhesion between the fabric and the phenolic matrix. Diammonium phosphate was applied to improve the flammability of the composites. The thermal and flammability properties of the untreated, chemically treated, and flame retardant (FR) treated flax fabric reinforced phenolic composites were studied. Ageing studies were carried out by subjecting the composites to varying conditions of temperature and humidity in an environmental chamber for 2 weeks. FR treatment of flax fabric was shown to be very effective in improving flame retardancy of the composites due to decreased peak heat release rate (PHRR) and smoke production rate (SPR). Thermogravimetric analysis (TGA) of composites showed that after FR treatment, the decomposition temperatures shifted to lower temperatures. Ageing studies revealed that the mechanical properties of untreated, chemically treated and FR treated composites decreased with an increase in ageing temperature.
Reorganization of the Connectivity between Elementary Functions – A Model Relating Conscious States to Neural Connections

In the present paper it is argued that the “neural correlate of consciousness” (NCC) does not appear to be a separate “module” – but an aspect of information processing within the neural substrate of various cognitive processes. Consequently, NCC can only be addressed adequately within frameworks that model the general relationship between neural processes and mental states – and take into account the dynamic connectivity of the brain. We presently offer the REFGEN (general reorganization of elementary functions) model as such a framework. This model builds upon and expands the REF (reorganization of elementary functions) and REFCON (of elementary functions and consciousness) models. All three models integrate the relationship between the neural and mental layers of description via the construction of an intermediate level dealing with computational states. The importance of experience based organization of neural and cognitive processes is stressed. The models assume that the mechanisms of consciousness are in principle the same as the basic mechanisms of all aspects of cognition – when information is processed to a sufficiently “high level” it becomes available to conscious experience. The NCC is within the REFGEN model seen as aspects of the dynamic and experience driven reorganizations of the synaptic connectivity between the neurocognitive “building blocks” of the model – the elementary functions.
Association Between Hyperoxia and Mortality After Stroke: A Multicenter Cohort Study*

Objective:To test the hypothesis that hyperoxia was associated with higher in-hospital mortality in ventilated stroke patients admitted to the ICU. Design:Retrospective multicenter cohort study. Setting:Primary admissions of ventilated stroke patients with acute ischemic stroke, subarachnoid hemorrhage, and intracerebral hemorrhage who had arterial blood gases within 24 hours of admission to the ICU at 84 U.S. ICUs between 2003 and 2008. Patients were divided into three exposure groups: hyperoxia was defined as PaO2 ≥300 mm Hg (39.99 kPa), hypoxia as any PaO2<60 mm Hg (7.99 kPa) or PaO2/FiO2 ratio ⩽300, and normoxia, not defined as hyperoxia or hypoxia. The primary outcome was in-hospital mortality. Participants:Two thousand eight hundred ninety-four patients. Methods:Patients were divided into three exposure groups: hyperoxia was defined as PaO2 more than or equal to 300 mm Hg (39.99 kPa), hypoxia as any PaO2 less than 60 mm Hg (7.99 kPa) or PaO2/FIO2 ratio less than or equal to 300, and normoxia, not defined as hyperoxia or hypoxia. The primary outcome was in-hospital mortality. Interventions:Exposure to hyperoxia. Results:Over the 5-year period, we identified 554 ventilated patients with acute ischemic stroke (19%), 936 ventilated patients with subarachnoid hemorrhage (32%), and 1,404 ventilated patients with intracerebral hemorrhage (49%) of whom 1,084 (38%) were normoxic, 1,316 (46%) were hypoxic, and 450 (16%) were hyperoxic. Mortality was higher in the hyperoxia group as compared with normoxia (crude odds ratio 1.7 [95% CI 1.3-2.1]; p < 0.0001) and hypoxia groups (crude odds ratio, 1.3 [95% CI, 1.1–1.7]; p < 0.01). In a multivariable analysis adjusted for admission diagnosis, other potential confounders, the probability of being exposed to hyperoxia, and hospital-specific effects, exposure to hyperoxia was independently associated with in-hospital mortality (adjusted odds ratio, 1.2 [95% CI, 1.04–1.5]). Conclusion:In ventilated stroke patients admitted to the ICU, arterial hyperoxia was independently associated with in-hospital death as compared with either normoxia or hypoxia. These data underscore the need for studies of controlled reoxygenation in ventilated critically ill stroke populations. In the absence of results from clinical trials, unnecessary oxygen delivery should be avoided in ventilated stroke patients.
Dynamical behavior of rate-based flow control mechanisms

Flow control mechanisms are essential for the efficient and stable operation of store-and-forward networks. New transport protocols, such as VMTP and NETBLT, intend to use rate-based flow control. We present a model in which a network with connections subject to rate-based flow control is considered as a dynamical system, i.e., a set of coupled differential equations. We consider two scenarios: (1) a single connection over a long delay path involving a bottleneck; and (2) two connections with different roundtrip delays that share a common bottleneck. For a recently proposed control scheme, we obtain closed-form solutions for the dynamical model in both transient and steady state regimes, and evaluate appropriate performance measures. We compare our results with those obtained by others using experimental and simulation approaches.
The strategic calculus of terrorism: Substitution and competition in the Israel—Palestine conflict

Previous work on the dynamics of conflicts where we see terrorism has tended to focus on whether we see shifts in attack mode following government countermeasures. We contend that many factors other than counterinsurgency can influence whether groups resort to terrorism, including competition between groups, as well as their relationship to public opinion and other political events. Hence, understanding terrorist tactics in prolonged conflicts with multiple actors requires us to consider a more general framework of innovation, imitation, competition and dependence between actors. We use disaggregated data on terrorist attacks, counterterrorism and public opinion in the Israel—Palestine conflict to jointly evaluate predictions derived from several conventional theories of strategic behaviour. We find that the strategic calculus of Palestinian groups is complex and cannot be treated as time invariant. Our results suggest that factors such as the degree of public support, inter-group competition, the anticipation of countermeasures and non-trivial non-violent payoffs have an observable effect on the strategic behaviour of the Palestinian groups, and that structural relationships are often far from constant over time.
Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells

Yeast Rad52 DNA‐repair mutants exhibit pronounced radiation sensitivity and a defect in homologous re combination (HR), whereas vertebrate cells lacking Rad52 exhibit a nearly normal phenotype. Bio chemical studies show that both yeast Rad52 and Rad55–57 (Rad51 paralogs) stimulate DNA‐strand exchange mediated by Rad51. These findings raise the possibility that Rad51 paralogs may compensate for lack of Rad52 in vertebrate cells, explaining the absence of prominent phenotypes for Rad52‐deficient cells. To test this hypothesis, using chicken DT40 cells, we generated conditional mutants deficient in both RAD52 and XRCC3, which is one of the five vertebrate RAD51 paralogs. Surprisingly, the rad52 xrcc3 double‐mutant cells were non‐viable and exhibited extensive chromosomal breaks, whereas rad52 and xrcc3 single mutants grew well. Our data reveal an overlapping (but non‐reciprocal) role for Rad52 and XRCC3 in repairing DNA double‐strand breaks. The present study shows that Rad52 can play an important role in HR repair by partially substituting for a Rad51 paralog.
Neighbor Overlap Is Enriched in the Yeast Interaction Network: Analysis and Implications

The yeast protein-protein interaction network has been shown to have distinct topological features such as a scale free degree distribution and a high level of clustering. Here we analyze an additional feature which is called Neighbor Overlap. This feature reflects the number of shared neighbors between a pair of proteins. We show that Neighbor Overlap is enriched in the yeast protein-protein interaction network compared with control networks carefully designed to match the characteristics of the yeast network in terms of degree distribution and clustering coefficient. Our analysis also reveals that pairs of proteins with high Neighbor Overlap have higher sequence similarity, more similar GO annotations and stronger genetic interactions than pairs with low ones. Finally, we demonstrate that pairs of proteins with redundant functions tend to have high Neighbor Overlap. We suggest that a combination of three mechanisms is the basis for this feature: The abundance of protein complexes, selection for backup of function, and the need to allow functional variation.
Efficacy of methotrexate in the treatment of nonruptured ectopic pregnancy, A six year experience at Polish Mother's Memorial Institute

The use of methotrexate to treat ectopic pregnancy was introduced in the 1990s. In 1982, Tanaka et al. was the first to treat intramural pregnancy with methotrexate successfully (1). More recently, Ory et al. (2) and then Stovall et al. (3) used methotrexate to treat unruptured ectopic pregnancies. Stovall et al. created the nonlaparoscopic diagnostic algorithm for ectopic pregnancy, which included serial assay of b-hCG, progesterone levels, transvaginal ultrasound and curettage (4). In our six year study we qualified for conservative therapy 51 patients with unruptured ectopic pregnancy. We treated these patients with a single dose of methotrexate (50 mg/m2). Our results are compared to those of other authors who used similar diagnostic and therapeutic techniques.
Sleeping well with cancer: a systematic review of cognitive behavioral therapy for insomnia in cancer patients

Individuals with cancer are disproportionately affected by sleep disturbance and insomnia relative to the general population. These problems can be a consequence of the psychological, behavioral, and physical effects of a cancer diagnosis and treatment. Insomnia often persists for years and, when combined with already high levels of cancer-related distress, may place cancer survivors at a higher risk of future physical and mental health problems and poorer quality of life. The recommended first-line treatment for insomnia is cognitive behavioral therapy for insomnia (CBT-I), a non-pharmacological treatment that incorporates cognitive and behavior-change techniques and targets dysfunctional attitudes, beliefs, and habits involving sleep. This article presents a comprehensive review of the literature examining the efficacy of CBT-I on sleep and psychological outcomes in cancer patients and survivors. The search revealed 12 studies (four uncontrolled, eight controlled) that evaluated the effects of CBT-I in cancer patients or survivors. Results suggest that CBT-I is associated with statistically and clinically significant improvements in subjective sleep outcomes in patients with cancer. CBT-I may also improve mood, fatigue, and overall quality of life, and can be successfully delivered through a variety of treatment modalities, making it possible to reach a broader range of patients who may not have access to more traditional programs. Future research in this area should focus on the translation of evidence into clinical practice in order to increase awareness and access to effective insomnia treatment in cancer care.
Wireless Amperometric Neurochemical Monitoring Using an Integrated Telemetry Circuit

An integrated circuit for wireless real-time monitoring of neurochemical activity in the nervous system is described. The chip is capable of conducting high-resolution amperometric measurements in four settings of the input current. The chip architecture includes a first-order DeltaSigma modulator (DeltaSigmaM) and a frequency-shift-keyed (FSK) voltage-controlled oscillator (VCO) operating near 433 MHz. It is fabricated using the AMI 0.5 mum double-poly triple-metal n -well CMOS process, and requires only one off-chip component for operation. Measured dc current resolutions of ~ 250 fA, ~ 1.5 pA, ~ 4.5 pA, and ~ 17 pA were achieved for input currents in the range of plusmn5, plusmn37, plusmn150, and plusmn600 nA, respectively. The chip has been interfaced with a diamond-coated, quartz-insulated, microneedle, tungsten electrode, and successfully recorded dopamine concentration levels as low as 0.5 muM wirelessly over a transmission distance of ~ 0.5 m in flow injection analysis experiments.
Carriage of stx2a Differentiates Clinical and Bovine-Biased Strains of Escherichia coli O157

Background Shiga toxin (Stx) are cardinal virulence factors of enterohemorrhagic E. coli O157:H7 (EHEC O157). The gene content and genomic insertion sites of Stx-associated bacteriophages differentiate clinical genotypes of EHEC O157 (CG, typical of clinical isolates) from bovine-biased genotypes (BBG, rarely identified among clinical isolates). This project was designed to identify bacteriophage-mediated differences that may affect the virulence of CG and BBG. Methods Stx-associated bacteriophage differences were identified by whole genome optical scans and characterized among >400 EHEC O157 clinical and cattle isolates by PCR. Results Optical restriction maps of BBG strains consistently differed from those of CG strains only in the chromosomal insertion sites of Stx2-associated bacteriophages. Multiplex PCRs (stx1, stx2a, and stx2c as well as Stx-associated bacteriophage - chromosomal insertion site junctions) revealed four CG and three BBG that accounted for >90% of isolates. All BBG contained stx2c and Stx2c-associated bacteriophage – sbcB junctions. All CG contained stx2a and Stx2a-associated bacteriophage junctions in wrbA or argW. Conclusions Presence or absence of stx2a (or another product encoded by the Stx2a-associated bacteriophage) is a parsimonious explanation for differential virulence of BBG and CG, as reflected in the distributions of these genotypes in humans and in the cattle reservoir.
Direct in vivo injection of 131I-GMS and its distribution and excretion in rabbit.

AIM To explore the distribution and metabolism of (131)I-gelatin microspheres ((131)I-GMSs) in rabbits after direct injection into rabbits' livers. METHODS Twenty-eight healthy New Zealand rabbits were divided into seven groups, with four rabbits per group. Each rabbit's hepatic lobes were directly injected with 41.336 +/- 5.106 MBq (131)I-GMSs. Each day after (131)I-GMSs administration, 4 rabbits were randomly selected, and 250 microL of serum was collected for gamma count. Hepatic and thyroid functions were tested on days 1, 4, 8, 16, 24, 32, 48 and 64 after (131)I-GMSs administration. Single-photon emission computed tomography (SPECT) was taken for each group on days 0, 1, 4, 8, 16, 24, 32, 48, 64 after (131)I-GMSs administration. A group of rabbits were sacrificed respectively on days 1, 4, 16, 24, 32, 48, 64 after (131)I-GMSs administration. Their livers were taken out for histological examination. RESULTS After (131)I-GMSs administration, the nuclide was collected in the hepatic area with microspheres. The radiation could be detected on day 48 after (131)I-GMSs administration, and radiography could be seen in thyroid areas in SPECT on days 4, 8, 16 and 24. One day after (131)I-GMSs administration, the liver function was damaged but recovered 4 d later. Eight days after (131)I-GMSs administration, the levels of free triiodothyronine and free thyroxin were reduced, which restored to normal levels on day 16. Histological examination showed that the microspheres were degraded to different degrees at 24, 32 and 48 d after (131)I-GMSs administration. The surrounding parts of injection points were in fibrous sheathing. No microspheres were detected in histological examination on day 64 after (131)I-GMSs administration. CONCLUSION Direct in vivo injection of (131)I-GMSs is safe in rabbits. It may be a promising method for treatment of malignant tumors.
The Relationship of Lyrics and Tunes in the Processing of Unfamiliar Songs: A Functional Magnetic Resonance Adaptation Study

The cognitive relationship between lyrics and tunes in song is currently under debate, with some researchers arguing that lyrics and tunes are represented as separate components, while others suggest that they are processed in integration. The present study addressed this issue by means of a functional magnetic resonance adaptation paradigm during passive listening to unfamiliar songs. The repetition and variation of lyrics and/or tunes in blocks of six songs was crossed in a 2 × 2 factorial design to induce selective adaptation for each component. Reductions of the hemodynamic response were observed along the superior temporal sulcus and gyrus (STS/STG) bilaterally. Within these regions, the left mid-STS showed an interaction of the adaptation effects for lyrics and tunes, suggesting an integrated processing of the two components at prelexical, phonemic processing levels. The degree of integration decayed toward more anterior regions of the left STS, where the lack of such an interaction and the stronger adaptation for lyrics than for tunes was suggestive of an independent processing of lyrics, perhaps resulting from the processing of meaning. Finally, evidence for an integrated representation of lyrics and tunes was found in the left dorsal precentral gyrus (PrCG), possibly relating to the build-up of a vocal code for singing in which musical and linguistic features of song are fused. Overall, these results demonstrate that lyrics and tunes are processed at varying degrees of integration (and separation) through the consecutive processing levels allocated along the posterior–anterior axis of the left STS and the left PrCG.
Development of early‐born γ‐Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthood

Early‐born γ‐aminobutyric acid (GABA) neurons (EBGNs) are major components of the hippocampal circuit because at early postnatal stages they form a subpopulation of “hub cells” transiently supporting CA3 network synchronization (Picardo et al. [2011] Neuron 71:695–709). It is therefore essential to determine when these cells acquire the remarkable morphofunctional attributes supporting their network function and whether they develop into a specific subtype of interneuron into adulthood. Inducible genetic fate mapping conveniently allows for the labeling of EBGNs throughout their life. EBGNs were first analyzed during the perinatal week. We observed that EBGNs acquired mature characteristics at the time when the first synapse‐driven synchronous activities appeared in the form of giant depolarizing potentials. The fate of EBGNs was next analyzed in the adult hippocampus by using anatomical characterization. Adult EBGNs included a significant proportion of cells projecting selectively to the septum; in turn, EBGNs were targeted by septal and entorhinal inputs. In addition, most EBGNs were strongly targeted by cholinergic and monoaminergic terminals, suggesting significant subcortical innervation. Finally, we found that some EBGNs located in the septum or the entorhinal cortex also displayed a long‐range projection that we traced to the hippocampus. Therefore, this study shows that the maturation of the morphophysiological properties of EBGNs mirrors the evolution of early network dynamics, suggesting that both phenomena may be causally linked. We propose that a subpopulation of EBGNs forms into adulthood a scaffold of GABAergic projection neurons linking the hippocampus to distant structures. J. Comp. Neurol. 524:2440–2461, 2016. © 2016 Wiley Periodicals, Inc.
MicroRNA in intervertebral disc degeneration

Aetiology of intervertebral disc degeneration (IDD) is complex, with genetic, developmental, biochemical and biomechanical factors contributing to the disease process. It is becoming obvious that epigenetic processes influence evolution of IDD as strongly as the genetic background. Deregulated phenotypes of nucleus pulposus cells, including differentiation, migration, proliferation and apoptosis, are involved in all stages of progression of human IDD. Non‐coding RNAs, including microRNAs, have recently been recognized as important regulators of gene expression. Research into roles of microRNAs in IDD has been very active over the past 5 years. Our review summarizes current research enlightenment towards understanding roles of microRNAs in regulating nucleus pulposus cell functions in IDD. These exciting findings support the notion that specific modulation of microRNAs may represent an attractive approach for management of IDD.
Effect of Pain Neuroscience Education and dry needling on chronic elbow pain as a result of cyberchondria: a case report

Abstract This case report describes a 31-year-old male who presented with complaints of chronic pain in his right elbow. Detailed subjective examination revealed that the patient had searched Google for extensive online information relating to his pain, ultimately self-labeling with various diagnoses. After researching in YouTube, the patient self-treated with ice, exercises, neural mobilization, self-massage and taping, all resulting in a failed outcome. Clinical findings revealed trigger points in his right brachioradialis muscle with added symptoms of central pain. This is a potential first-time description of physical therapy management of brachioradialis myofascial pain syndrome with superadded central pain caused as a result of cyberchondria where the patient used the Internet for arriving at a wrong self-diagnosis and incorrect self-treatment with failed or worsening pain outcomes leading to pain sustenance or chronicity. Physical therapy consisted of Pain Neuroscience Education, dry needling and exercise therapy. The patient was completely pain free and fully functional at the end of the sixth session, which was maintained at a one-month follow-up.