Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationship between post-traumatic stress disorder, depression and cardiovascular disease in an American Indian tribe

Background. Empirical findings suggest that psychiatric illness is associated with cardiovascular disease (CVD). The purpose of this study was to compare the strength of the association of lifetime post-traumatic stress disorder (PTSD) and lifetime major depression on CVD among Northern Plains American Indians. Method. A total of 1414 participants aged 18–57 years completed a structured interview that assessed psychiatric diagnoses, alcohol abuse/dependence, self-reported CVD, and traditional CVD risk factors including age, sex, education, diabetes, high blood pressure, and smoking. Logistic regression analyses compared the odds ratios of CVD in participants with and without diagnosed PTSD or major depression. Results. The rates of lifetime PTSD and major depression were 15% and 8% respectively. CVD was more commonly reported by participants with PTSD than by those without PTSD (12% v. 5%, p[les ]0·01). Likewise, more participants with major depression reported CVD than did their non-depressed counterparts (14% v. 6%, p[les ]0·05). PTSD was significantly associated with CVD even after controlling for traditional CVD risk factors and major depression (odds ratio 2·0, confidence interval 1·1–3·8). In contrast, the association of major depression with CVD was not significant after accounting for both traditional risk factors and PTSD. Conclusions. Rates of PTSD are high in American Indian communities. Rising CVD rates in this population may be better understood if PTSD is considered along with other traditional risk factors. Future research should examine the association and mechanisms of PTSD and CVD prospectively. Such data could lead to more effective CVD prevention efforts for American Indians.
THE POWER OF POLITICS ON ORGANIZATIONAL LEARNING AND KNOWLEDGE CREATION

In this paper it is argued that political processes, within and between organizations, need to be included in discussions about knowledge generation. Acquisition of new knowledge is always associated with different interests from a variety of actors. The learning processes are to a large extent governed by political ideology, prescribing what is valuable learning and what is not. The research presented in this paper indicates that political issues, hidden agenda and closed networks tend to be present, in learning processes, deciding what the result of an innovation shall be, Kirkebak (2000). This influence what is being learned, and by whom. This paper demonstrates how the power of politics manifests itself during the innovation process, as a division between the studied organization's core and periphery. In particular the dynamics between periphery and core in terms of power differences and whether actors or actor groups have a fair chance to get heard. The innovation process in this paper is studied both at the micro level at Peterson, and at the macro level as an industrial programme initiated by regional authorities, in the Ostfold County of Norway, to promote innovation and growth among a number of targeted industries. Alvesson (2002) claim that 'even if power is not solely negative, the concept draws attention to how someone is being subordinated and shaped in accordance with a particular regular force, giving priority to certain interest and neglecting other' (pp. 122). Our research support this claim by focusing on the division that power of politics introduces between what we define as the periphery and core in the studied organizations. In all learning processes there will be partakers who have a personal interest in participating, and these persons have the power to decide what the content of the learning process should be, and thus influences what is being learned. This is what we can find it the actor-network-theory (ANT) (Latour, 1987; Callon and Law, 1982). Vital in the ANT is that actors construct networks to further specific viewpoints, and where the essence is the power play during construction of the innovation process. This result becomes a documentation of what actors had access to what resources during the innovation process (Levin, 2002). Nevertheless there are reasons to question if the politics of power is something old, that has always been 3 there and always will, or if it is possible to see traces of a new regime of …
Increased frequencies of interleukin-2- and interferon-gamma-producing T cells in patients with active Behçet's disease.

PURPOSE To elucidate the profile of cytokine-producing T cells in patients with active or inactive Behçet's disease (BD), the frequencies of type 1 (Interleukin- [IL] 2, interferon-gamma [IFN-gamma]) and type 2 (IL-4) cytokine-producing CD4+ and CD8+ cells in peripheral blood were investigated, and the effect of immunosuppressive drugs on the profile of cytokine-producing cells was evaluated. METHODS Fifty-two patients with BD (32 with active and 20 with inactive BD) and 33 healthy control subjects were the subjects in this study. Patients were or were not treated with immunosuppressive drugs. Peripheral blood mononuclear cells were fixed, permeabilized, and stained for intracellular cytokines in combination with cell surface markers CD4 and CD8 for flow cytometric analysis. RESULTS In nontreated patients with BD, the frequencies of IL-2- and IFN-gamma-producing CD4 and CD8+ cells in active patients were significantly higher than those in inactive patients. Conversely, the frequencies of IL-4 producing CD4+ and CD8+ cells in nontreated patients with active BD were comparable with those in patients with inactive disease and in control subjects. Patients with inactive BD who were treated with immunosuppressive drugs showed significantly lower frequencies of IL-2- and IFN-gamma-producing CD4+ and CD8+ cells than did treated patients with active BD. CONCLUSIONS The frequencies of type 1 cytokine-producing CD4+ and CD8+ cells increased in patients with active BD. Effective immunosuppressive treatments decreased the population of type 1 cytokine-producing CD4+ and CD8+ cells. These results suggest that type 1 cytokine-producing cells play an important role in the immunopathogenesis of the inflammation in BD.
Leveraging User Reviews to Improve Accuracy for Mobile App Retrieval

Smartphones and tablets with their apps pervaded our everyday life, leading to a new demand for search tools to help users find the right apps to satisfy their immediate needs. While there are a few commercial mobile app search engines available, the new task of mobile app retrieval has not yet been rigorously studied. Indeed, there does not yet exist a test collection for quantitatively evaluating this new retrieval task. In this paper, we first study the effectiveness of the state-of-the-art retrieval models for the app retrieval task using a new app retrieval test data we created. We then propose and study a novel approach that generates a new representation for each app. Our key idea is to leverage user reviews to find out important features of apps and bridge vocabulary gap between app developers and users. Specifically, we jointly model app descriptions and user reviews using topic model in order to generate app representations while excluding noise in reviews. Experiment results indicate that the proposed approach is effective and outperforms the state-of-the-art retrieval models for app retrieval.
Fulvestrant in advanced breast cancer: evidence to date and place in therapy

Breast cancer is a classical hormone-dependent tumour; therefore, endocrine therapy is the mainstay of treatment for hormone receptor-positive, human epidermal growth factor 2-negative advanced breast cancer. Until recently, classical endocrine agents such as tamoxifen, steroidal and nonsteroidal aromatase inhibitors and fulvestrant have been widely used in postmenopausal patients to treat locally advanced or metastatic disease. However, for patients with this subtype of breast cancer, the landscape of endocrine therapy is rapidly changing. Therapies targeting oestrogen modulation have evolved in recent years following the introduction of targeted agents, mTOR and CDK 4/6 inhibitors that are administered in combination with hormone therapy. As a result, options for endocrine therapy have expanded in recent years, and a variety of single-agent or combinations of targeted drugs and endocrine therapies are accepted. Fulvestrant is a selective oestrogen receptor downregulator (SERD) which was introduced to clinical practice in 2002, initially with the indication to treat postmenopausal women with hormone-receptor-positive advanced breast cancer as second-line therapy postdisease progression after aromatase inhibitors or tamoxifen. Additionally, fulvestrant has also been shown to be active in patients previously untreated with endocrine therapy, either both in the neoadjuvant and the metastatic setting, alone or in combination with other targeted therapies. Currently, the standard dose is 500 mg, which is administered with a loading dose. Fulvestrant received a new FDA indication in December 2016, in combination with palbociclib, both in pre/peri/postmenopausal women with breast cancer progressing after endocrine therapy. This manuscript aims to give an overview of new efficacy data and the current role of fulvestrant in the systemic therapy of hormone-receptor-positive advanced breast cancer, in the context of other available therapeutic modalities.
The Neural Bases of Distraction and Reappraisal

Distraction and reappraisal are two commonly used forms of cognitive emotion regulation. Functional neuroimaging studies have shown that each one depends upon interactions between pFC, interpreted as implementing cognitive control, and limbic regions, interpreted as mediating emotional responses. However, no study has directly compared distraction with reappraisal, and it remains unclear whether they draw upon different neural mechanisms and have different emotional consequences. The present fMRI study compared distraction and reappraisal and found both similarities and differences between the two forms of emotion regulation. Both resulted in decreased negative affect, decreased activation in the amygdala, and increased activation in prefrontal and cingulate regions. Relative to distraction, reappraisal led to greater decreases in negative affect and to greater increases in a network of regions associated with processing affective meaning (medial prefrontal and anterior temporal cortices). Relative to reappraisal, distraction led to greater decreases in amygdala activation and to greater increases in activation in prefrontal and parietal regions. Taken together, these data suggest that distraction and reappraisal differentially engage neural systems involved in attentional deployment and cognitive reframing and have different emotional consequences.
Complementary and Alternative Medicine Utilization in Texas Hospices

The purpose of this study was to describe the prevalence, importance, and challenges of complementary and alternative medicine (CAM) utilization in Texas hospices. Mail surveys were sent to 369 hospices in Texas, and 110 useful surveys were returned. Results showed that a majority (n = 62, 56.4%) of hospices offer CAM to their clients, with the most popularly offered CAMs being massage, music, and relaxation therapies. Despite the availability of CAM services in most hospices, and that the utilization of CAM has the potential to improve overall quality of life of patients, our results showed that a sizeable proportion of patients in these hospices are not utilizing the provided CAMs. Funding and personnel constraints were substantial obstacles to offering CAM.
Molecular Characterization of Eimeria Species Naturally Infecting Egyptian Baldi Chickens

Background: Coccidiosis is a serious protozoal disease of poultry. The identification of Eimeria species has important implications for diagnosis and control as well as for epidemiology. The molecular characterization of Eimeria species infecting Egyptian baladi chickens was investigated. Methods: Eimeria species oocysts were harvested from intestines of naturally infected Egyptian baldi chickens. The morphometry characterization of oocysts along with COCCIMORPH software was done. The DNA was extracted initially by freezing and thawing then the prepared samples was subjected to commercial DNA kits. The DNA products were analyzed through conventional polymerase chain reaction by using amplified region (SCAR) marker. Results: The PCR results confirmed the presence of 7 Eimeria species in the examined fecal samples of Egyptian baldi breed with their specific ampilicon sizes being E. acervulina (811bp), E. brunette (626bp), E. tenella (539bp), E. maxima (272bp), E. necatrix (200bp), E. mitis (327bp) and E. praecopx (354bp). A sequencing of the two most predominant species of Eimeria was done, on E. tenella and E. máxima. Analysis of the obtained sequences revealed high identities 99% between Egyptian isolates and the reference one. Similarly, E. maxima isolated from Egyptian baldi chickens showed 98% nucleotide identities with the reference strain. Only single nucleotide substitution was observed among the Egyptian E. tenella isolates (A181G) when compared to the reference one. The Egyptian isolates acquired 4 unique mutations (A68T, C164T, G190A and C227G) in compared with the reference sequence. Conclusion: This is the first time to identify the 7 species of Eimeria from Egyptian baladi chickens.
The Allocation of Attention and Working Memory in Visual Crowding

When the distance between a visual target and nearby flankers falls below a critical distance, target discrimination declines precipitously. This is called “crowding. ” Many researchers have proposed that selective attention plays a role in crowding. However, although some research has examined the effects of directing attention toward versus away from the targets, no previous research has assessed how attentional allocation varies as a function of target–flanker distance in crowding. Here, we used ERPs to assess the operation of attention during crowding, focusing on the attention-related N2pc component. We used a typical crowding task in which participants were asked to report the category (vowel/consonant) of a lateralized target letter flanked by distractor letters at different distances. We tested the hypothesis that attention fails when the target–flanker distance becomes too small for attention to operate effectively. Consistent with this hypothesis, we found that N2pc amplitude was maximal at intermediate target–flanker distances and decreased substantially when crowding became severe. In addition, we examined the sustained posterior contralateral negativity (SPCN), which reflects the amount of information being maintained in working memory. Unlike the N2pc component, the SPCN increased in amplitude at small target–flanker distances, suggesting that observers stored information about the target and flankers in working memory when attention failed to select the target. Together, the N2pc and SPCN results suggest that attention and working memory play distinctive roles in crowding: Attention operates to minimize interference from the flankers at intermediate target–flanker distances, whereas working memory may be recruited when attention fails to select the target at small target–flanker distances.
Prevalence of Metabolic Syndrome in Urban India

Background. Metabolic syndrome (MS) is characterised by a constellation of individual risk factors of cardiovascular disease. Materials and Methods. The current study was a population-based survey of cohort of subjects in the metropolitan city of Mumbai. A total of 548 subjects, who attended the CARDIAC evaluation camp, were recruited in the study. Participants with complete fasting lipid profiles, blood glucose, and known cardiac risk markers were evaluated. Results. On applying modified NCEP ATP III, we found out that nearly 95% of the subjects had at least one abnormal parameter. We found the prevalence of MS in our study population to be 19.52%. The prevalence of MS in males was almost double than females (P = .008). The overall prevalence of BMI (>23 kg/m2) was 79.01%. Increased hypertriglyceridemia and decreased levels of HDL-C were found to be more in males (P < .0001). Conclusion. The low percentage of subjects with normal and controlled parameters suggests that there is a need for awareness programs and lifestyle interventions for the prevention and control of MS.
Role of vascular channels as a novel mechanism for subchondral bone damage at cruciate ligament entheses in osteoarthritis and inflammatory arthritis

Objectives The purpose of this work was to test whether normal peri-entheseal vascular anatomy at anterior and posterior cruciate ligaments (ACL and PCL) was associated with distribution of peri-entheseal bone erosion/bone marrow lesions (BMLs) in inflammatory arthritis (IA) and osteoarthritis (OA). Methods Normal microanatomy was defined histologically in mice and by 3 T MRI and histology in 21 cadaveric knees. MRI of 89 patients from the Osteoarthritis Initiative and 27 patients with IA was evaluated for BMLs at ACL and PCL entheses. Antigen-induced arthritis (AIA) in mice was evaluated to ascertain whether putative peri-entheseal vascular regions influenced osteitis and bone erosion. Results Vascular channels penetrating cortical bone were identified in knees of non-arthritic mice adjacent to the cruciate ligaments. On MRI of normal cadavers, vascular channels adjacent to the ACL (64% of cases) and PCL (71%) entheses were observed. Histology of 10 macroscopically normal cadaveric specimens confirmed the location of vascular channels and associated subclinical changes including subchondral bone damage (80% of cases) and micro-cyst formation (50%). In the AIA model, vascular channels clearly provided a site for inflammatory tissue entry and osteoclast activation. MRI showed BMLs in the same topographic locations in both patients with early OA (41% ACL, 59% PCL) and IA (44%, 33%). Conclusion The findings show that normal ACL and PCL entheses have immediately adjacent vascular channels which are common sites of subtle bone marrow pathology in non-arthritic joints. These channels appear to be key determinants in bone damage in inflammatory and degenerative arthritis.
Author ' s personal copy Compared to a small , supervised lab experiment , a large , unsupervised web-based experiment on a previously unknown effect has benefits that outweigh its potential costs q

Research on internet-based studies has generally supported their benefits. However, that research sometimes did not directly compare internet-based to traditional delivery, often used non-experimental methods and small samples, and has not used an entirely unknown effect for the comparison to completely rule out demand characteristics. Our lab experiment (N = 180), in which participants were supervised by an experimenter, demonstrated previously unexamined effects. Both the frighteningness and disgustingness of insects made people want to kill them, and females wanted to kill the insects more than males did. There were also some interesting patterns of interaction with gender, but they were not statistically significant. However, an unsupervised, but larger, web-based experiment (N = 1301) produced the same significant main effects as the lab study, and the same patterns of interaction that had occurred at a nonsignificant level in the lab study occurred at a statistically significant level in the web-based study. These results add support to the finding that although web-based studies may incur risks by being unsupervised, such as some participants not being genuinely motivated to follow the instructions correctly, the risks are compensated for by the much larger sample size afforded by the web-based approach. 2013 Elsevier Ltd. All rights reserved.
Color vision.

Color vision starts with the absorption of light in the retinal cone photoreceptors, which transduce electromagnetic energy into electrical voltages. These voltages are transformed into action potentials by a complicated network of cells in the retina. The information is sent to the visual cortex via the lateral geniculate nucleus (LGN) in three separate color-opponent channels that have been characterized psychophysically, physiologically, and computationally. The properties of cells in the retina and LGN account for a surprisingly large body of psychophysical literature. This suggests that several fundamental computations involved in color perception occur at early levels of processing. In the cortex, information from the three retino-geniculate channels is combined to enable perception of a large variety of different hues. Furthermore, recent evidence suggests that color analysis and coding cannot be separated from the analysis and coding of other visual attributes such as form and motion. Though there are some brain areas that are more sensitive to color than others, color vision emerges through the combined activity of neurons in many different areas.
10 Gbit/s FP-TOSA and PIN-ROSA for 10GBASE-LRM application

Wide temperature operating 10 Gbit/s 1.3 /spl mu/m AlGaInAs FP-TOSA and InGaAs PIN-ROSA were newly developed for 10GBASE-LRM application. Error-free 330 m MMF transmission was successfully demonstrated using these components and EDC for the first time.
Reproductive Biology and Endocrinology Open Access Gelatinase (mmp-2 and -9) Expression Profiles during Gestation in the Bovine Endometrium

Background: Various molecules participate in implantation and maintaining endometrial function during gestation. The remodeling of endometrial matrices is a necessary process in the coordination of gestational progress. Matrix-metalloproteinases (MMPs) like gelatinases (MMP-2 and-9) and collagenase (MMP-1) are considered to play important roles in this process. We examined MMP-2 and-9 expression using zymography, in situ hybridization, real-time PCR, and microarray analysis to clarify their roles in the bovine endometrium during gestation.
Hypoxaemia as a Mortality Risk Factor in Acute Lower Respiratory Infections in Children in Low and Middle-Income Countries: Systematic Review and Meta-Analysis

Objective To evaluate the association between hypoxaemia and mortality from acute lower respiratory infections (ALRI) in children in low- and middle-income countries (LMIC). Design Systematic review and meta-analysis. Study Selection Observational studies reporting on the association between hypoxaemia and death from ALRI in children below five years in LMIC. Data Sources Medline, Embase, Global Health Library, Lilacs, and Web of Science to February 2015. Risk of Bias Assessment Quality In Prognosis Studies tool with minor adaptations to assess the risk of bias; funnel plots and Egger’s test to evaluate publication bias. Results Out of 11,627 papers retrieved, 18 studies from 13 countries on 20,224 children met the inclusion criteria. Twelve (66.6%) studies had either low or moderate risk of bias. Hypoxaemia defined as oxygen saturation rate (SpO2) <90% associated with significantly increased odds of death from ALRI (OR 5.47, 95% CI 3.93 to 7.63) in 12 studies on 13,936 children. An Sp02 <92% associated with a similar increased risk of mortality (OR 3.66, 95% CI 1.42 to 9.47) in 3 studies on 673 children. Sensitivity analyses (excluding studies with high risk of bias and using adjusted OR) and subgroup analyses (by: altitude, definition of ALRI, country income, HIV prevalence) did not affect results. Only one study was performed on children living at high altitude. Conclusions The results of this review support the routine evaluation of SpO2 for identifying children with ALRI at increased risk of death. Both a Sp02 value of 92% and 90% equally identify children at increased risk of mortality. More research is needed on children living at high altitude. Policy makers in LMIC should aim at improving the regular use of pulse oximetry and the availability of oxygen in order to decrease mortality from ALRI.