Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptive packet equalization for indoor radio channel using multilayer neural networks

This paper investigates the application of the multilayer perceptron structure to the packet-wise adaptive decision feedback equalization of a M-ary QAM signal through a TDMA indoor radio channel in the presence of intersymbol interference (ISI) and additive Gaussian noise. Since the multilayer neural networks are capable of producing complex decision regions with arbitrarily nonlinear boundaries, this would greatly improve the performance of conventional decision feedback equalizer (DFE) where the decision boundaries of conventional DFE are linear. However, the applications of the traditional multilayer neural networks have been limited to real-valued signals. To tackle this difficulty, a neural-based DPE is proposed to deal with the complex QAM signal over the complex-valued fading multipath radio channel without performing time-consuming complex-valued back-propagation training algorithms, while maintaining almost the same computational complexity as the original real-valued training algorithm. Moreover, this neural-based DFE trained by packet-wise backpropagation algorithm would approach an ideal equalizer after receiving a sufficient number of packets. In this paper, another fast packet-wise training algorithm with better convergence properties is derived on the basis of a recursive least-squares (RLS) routine. Results show that the neural-based DFE trained by both algorithms provides a superior bit-error-rate performance relative to the conventional least mean square (LMS) DFE, especially in poor signal to noise ratio conditions. >
A comparative analysis of the cardiovascular disease risk factor profiles of Pacific peoples and Europeans living in New Zealand assessed in routine primary care: PREDICT CVD-11.

AIM To investigate the differences in the baseline cardiovascular disease (CVD) risk profiles of Pacific peoples and Europeans assessed in routine primary care practice by PREDICT, a web-based clinical decision support programme for assessing and managing CVD risk. METHODS PREDICT has been implemented in primary care practices from nine consenting PHOs in Auckland and Northland. Between 2002 and January 2009, over 70,000 CVD risk assessments were conducted. These analyses compare CVD risk factors for Pacific and European patients. RESULTS Baseline risk assessments were completed for 39,835 Europeans and 10,301 Pacific peoples aged 35-74 years. Over 85% of the Pacific cohort was comprised of the four main Pacific ethnic groups in New Zealand (Samoan, Tongan, Cook Island Maori and Niuean). Fijians (n=1341) were excluded from the analyses because of a likely misclassification error with Indian Fijians. On average, Pacific peoples in the PREDICT cohort were 4 years younger at the time of risk assessment than Europeans, and were overrepresented in areas of high socioeconomic deprivation. At risk assessment, Pacific men were 1.5 times as likely to be current smokers as European men, whereas similar or lower proportions of Pacific women smoked compared with European women. Pacific peoples were approximately three times more likely to have diabetes as Europeans. Pacific peoples had higher diastolic blood pressures and Pacific women had higher total cholesterol/HDL ratios. Both Pacific men and women had a significantly higher predicted risk of CVD in the next 5 years than Europeans, based on the Framingham risk score. CONCLUSIONS The PREDICT programme has already generated the largest cohort of Pacific peoples ever to be studied in New Zealand. This comparative analysis of patients who have been screened highlights significant disparities in CVD risk factors for Pacific peoples particularly for diabetes in both sexes and for smoking in men. Targeting these modifiable risk factors will be important in addressing the widening inequalities in CVD outcomes between Pacific peoples and Europeans.
Cytopenias among ART-naive patients with advanced HIV disease on enrolment to care and treatment services at a tertiary hospital in Tanzania: A cross-sectional study.

BACKGROUND HIV/AIDS causes high morbidity and mortality through both immunosuppression and complications not directly related to immunosuppression. Haematological abnormalities, including various cytopenias, occur commonly in HIV through immune and non-immune pathways. Though these complications could potentially cause serious clinical implications, published literature on the magnitude of this problem and its associated factors in Tanzania is scarce. This study aimed at determining the prevalence and risk factors of HIV-associated cytopenias among ART-naive patients enrolling for care and treatment services at Bugando Care and Treatment Centre (CTC) in Mwanza, Tanzania. METHODS This was a cross-sectional clinic-based study done between March 2015 and February 2016, involving all antiretroviral therapy (ART)-naive adult HIV-positive patients enrolling for care and treatment services at Bugando CTC. Patients younger than 18 years and those with missing data were excluded. Data were analysed using Stata version 11 to determine the prevalence and risk factors of cytopenias. RESULTS A total of 1205 ART-naive patients were included. Median age was 41 years (interquartile range [IQR] 32 to 48). Most participants were female (n = 789; 65.6%), with a female-to-male ratio of 2:1. The median baseline CD4 count was 200 cells/µL (IQR 113 to 439). About half (49%) of the study participants had baseline CD4 counts less than 200 cells/µL. Anaemia, leucopenia, and thrombocytopenia were found in 704 (58.4%), 285 (23.6%), and 174 (14.4%) participants, respectively, and these were strongly associated with advanced HIV infection. CONCLUSIONS The magnitude of cytopenias is high among ART-naive HIV-positive adults, and cytopenias are more marked with advanced HIV infection. Early diagnosis of HIV and timely initiation of ART could potentially reduce the number of people living with advanced HIV disease and its associated complications, including the cytopenias investigated in this study. Patients with cytopenias should undergo thorough screening for tuberculosis, which is an important and treatable correlate of cytopenia, in addition to close follow-up for any potential negative outcomes.
An assessment of Mobile Broadband Access in Indonesia: a Demand or Supply Problem?

Previous studies conclude that broadband plays an important role in stimulating economic growth by generating new employment, and improving access to health and education. However, most of these analyses are conducted for developed countries, with little attention being paid to developing countries. This study aims to find out which factors should be considered, following the assertion by the ITU (2010) that broadband, especially mobile broadband, should be developed further to narrow the gap between developed and developing countries. Moreover, this study questions whether the digital gap in broadband access is merely a demand or supply problem. The demand side is represented by income level, which is closely related to affordability issues, while the supply side is indicated by the impact of different geographical characteristics which shows the different stage of infrastructure development. To operationalize this aim, a Probit regression models the decision to subscribe to mobile broadband as a function of income and geographical area, as well as other control variables. The results indicate that income is less important than geographical area in explaining mobile broadband access. The study proposes that the supply -side factor related to infrastructure development should be prioritized as the focus of broadband policy in the short term.
Tomato facultative parthenocarpy results from SlAGAMOUS‐LIKE 6 loss of function

Summary The extreme sensitivity of the microsporogenesis process to moderately high or low temperatures is a major hindrance for tomato (Solanum lycopersicum) sexual reproduction and hence year‐round cropping. Consequently, breeding for parthenocarpy, namely, fertilization‐independent fruit set, is considered a valuable goal especially for maintaining sustainable agriculture in the face of global warming. A mutant capable of setting high‐quality seedless (parthenocarpic) fruit was found following a screen of EMS‐mutagenized tomato population for yielding under heat stress. Next‐generation sequencing followed by marker‐assisted mapping and CRISPR/Cas9 gene knockout confirmed that a mutation in SlAGAMOUS‐LIKE 6 (SlAGL6) was responsible for the parthenocarpic phenotype. The mutant is capable of fruit production under heat stress conditions that severely hamper fertilization‐dependent fruit set. Different from other tomato recessive monogenic mutants for parthenocarpy, Slagl6 mutations impose no homeotic changes, the seedless fruits are of normal weight and shape, pollen viability is unaffected, and sexual reproduction capacity is maintained, thus making Slagl6 an attractive gene for facultative parthenocarpy. The characteristics of the analysed mutant combined with the gene's mode of expression imply SlAGL6 as a key regulator of the transition between the state of ‘ovary arrest’ imposed towards anthesis and the fertilization‐triggered fruit set.
Immortalized Chromaffin Cells Disimmortalized with Cre/lox Site-Directed Recombination for Use in Cell Therapy for Pain after Partial Nerve Injury

To prepare immortalized adrenal chromaffin cells for eventual clinical use, the immortalizing oncogene must be removed. We have utilized a Cre-mediated excision of a loxP-flanked Tag sequence to test whether immortalized chromaffin cells could be disimmortalized by this method. Cultures of embryonic rat adrenal cells were immortalized with the tsA-TN retroviral vector encoding the loxP-flanked temperature-sensitive allele of SV40 large T antigen (tsA-TN) and a positive/negative neo/HSV-TK sequence for selection with either G418 or gancyclovir, respectively. These cells were then infected with the 1710-CrePR1 bicistronic retroviral vector coding for a form of Cre modulatable by the synthetic steroid RU486. These immortalized loxTsTag/CrePR1/RAD cells expressed immunoreactivities (ir) for all the catecholamine enzymes: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DbetaH), and phenylethanolamine-N-methyltransferase (PNMT). After initial incubation at 37 degrees C with RU486 for 3 days, followed by the addition of gancyclovir for 7 days, Tag-ir was not detectable in most of the surviving chromaffin cells, compared to 100% expression in immortalized loxTsTag/CreR1/RAD cells not treated with RU486 and gancyclovir. The expression of TH, DbetaH, and PNMT was increased after disimmortalization and the ability of disimmortalized cells to synthesize norepinephrine was also significantly increased compared to immortalized cells. When both types of chromaffin cells were transplanted in a model of neuropathic pain and partial nerve injury, both cell grafts were equally able to reverse the behavioral hypersensitivity induced by the injury. The use of Cre/lox site-directed disimmortalization of chromaffin cells that are able to deliver neuroactive molecules offers a novel approach to cell therapy.
Impact and mechanism of mental practice effects on strength

Abstract This investigation examined the predictions of psychoneuromuscular theory (Richardson, 1967) and the effectiveness of mental practice (MP) in enhancing strength performance, using a finger strength task. Eighteen males were randomly assigned to a physical practice (PP) group, a mental practice (MP) group or a control group. PP and MP participants performed two PP or MP sessions per week for four weeks, each session comprising twenty real or imagined maximal contractions of the abductor digiti minimi. There were no significant differences in pre‐test abduction force, but post‐test scores of the PP and MP groups were significantly greater than those of control participants. Electromyographic (EMG) recordings revealed significant muscle activity during MP, but its magnitude was not significantly correlated with the degree of performance enhancement. Findings therefore supported the effectiveness of MP in enhancing strength performance, but were not supportive of psychoneuromuscular theory.
The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis

CXCR4 is the receptor of the chemokine CXCL12, which is involved in progression and metastasis of several types of cancer cells, HIV infection and rheumatoid arthritis. The authors developed selective CXCR4 antagonists, T22 and T140, initially as anti-HIV agents, which inhibit T cell line-tropic (X4-) HIV-1 infection through their specific binding to CXCR4. Recently, T140 analogues have also been shown to inhibit CXCL12-induced migration of breast cancer cells, leukaemia T cells, pancreatic cancer cells, small cell lung cancer cells, chronic lymphocytic leukaemia B cells, pre-B acute lymphoblastic leukaemia cells and so on in vitro. Biostable T140 analogues significantly suppressed pulmonary metastasis of breast cancer cells and melanoma cells in mice. Furthermore, these compounds significantly suppressed the delayed-type hypersensitivity response induced by sheep red blood cells and collagen-induced arthritis, which represent in vivo mouse models of arthritis. Thus, T140 analogues proved to be attractive lead compounds for chemotherapy of these problematic diseases. This article reviews recent research on T140 analogues, referring to several other CXCR4 antagonists.
Darbepoetin alpha for the treatment of anemia in patients with active cancer not receiving chemotherapy or radiotherapy: results of a phase III, multicenter, randomized, double-blind, placebo-controlled study.

PURPOSE The efficacy and safety of darbepoetin alpha (DA) for treating patients with active cancer and anemia not receiving or planning to receive cytotoxic chemotherapy or myelosuppressive radiotherapy was evaluated. PATIENTS AND METHODS Patients with active cancer and anemia not receiving or planning to receive chemotherapy or radiotherapy were enrolled onto a phase III, multicenter, randomized, placebo-controlled study and administered placebo or DA 6.75 microg/kg every 4 weeks (Q4W) for up to 16 weeks with a 2-year follow-up for survival. Patients who completed 16 weeks of treatment could receive the same treatment as randomized Q4W for an additional 16 weeks. The primary end point was all occurrences of transfusions from weeks 5 through 17; safety end points included incidence of adverse events and survival. RESULTS The incidence of transfusions between weeks 5 and 17 was lower in the DA group but was not statistically significantly different from that of placebo. DA was associated with an increased incidence of cardiovascular and thromboembolic events and more deaths during the initial 16-week treatment period. Long-term survival data demonstrated statistically significantly poorer survival in patients treated with DA versus placebo (P = .022). This effect varied by baseline covariates including, sex, tumor type, and geographic region; statistical significance diminished (P = .12) when the analysis was adjusted for baseline imbalances or known prognostic factors. CONCLUSION DA was not associated with a statistically significant reduction in transfusions. Shorter survival was observed in the DA arm; thus, this study does not support the use of erythropoiesis-stimulating agents in this subset of patients with anemia of cancer.
Pragmatic criteria of the definition of neonatal near miss: a comparative study

ABSTRACT OBJECTIVE The objective of this study was to test the validity of the pragmatic criteria of the definitions of neonatal near miss, extending them throughout the infant period, and to estimate the indicators of perinatal care in public maternity hospitals. METHODS A cohort of live births from six maternity hospitals in the municipalities of São Paulo, Niterói, and Rio de Janeiro, Brazil, was carried out in 2011. We carried out interviews and checked prenatal cards and medical records. We compared the pragmatic criteria (birth weight, gestational age, and 5’ Apgar score) of the definitions of near miss of Pileggi et al., Pileggi-Castro et al., Souza et al., and Silva et al. We calculated sensitivity, specificity (gold standard: infant mortality), percentage of deaths among newborns with life-threatening conditions, and rates of near miss, mortality, and severe outcomes per 1,000 live births. RESULTS A total 7,315 newborns were analyzed (completeness of information > 99%). The sensitivity of the definition of Pileggi-Castro et al. was higher, resulting in a higher number of cases of near miss, Souza et al. presented lower value, and Pileggi et al. and de Silva et al. presented intermediate values. There is an increase in sensitivity when the period goes from 0–6 to 0–27 days, and there is a decrease when it goes to 0–364 days. Specificities were high (≥ 97%) and above sensitivities (54% to 77%). One maternity hospital in São Paulo and one in Niterói presented, respectively, the lowest and highest rates of infant mortality, near miss, and frequency of births with life-threatening conditions, regardless of the definition. CONCLUSIONS The definitions of near miss based exclusively on pragmatic criteria are valid and can be used for monitoring purposes. Based on the perinatal literature, the cutoff points adopted by Silva et al. were more appropriate. Periodic studies could apply a more complete definition, incorporating clinical, laboratory, and management criteria, including congenital anomalies predictive of infant mortality.
Men, masculinities and children: some European perspectives

Gender matters in child welfare partly by virtue of the relationship of men, masculinities and men’s practices to children, young people and childcare. This problematic is considered within a European context. The article sets out some of the major ways in which men relate, or do not relate, to children and young people. These include men’s care of, violence to and abuse of children and young people. Drawing on work with the EU Research Network, ‘The Social Problem of Men’, we locate men’s relation to children in the context of men’s gendered position within different European societies and ‘welfare states’. The final part of this article discusses more research and policy on men, children and childcare. These include somewhat contradictory findings on parental leave, violence and abuse, and professional interventions in Nordic, supposedly ‘women-friendly’ ‘welfare societies’.
Creativity and Impulsivity in the Lab: A Microgenetic Approach

In the Creative Functioning Test, a participant is exposed to a series of briefly presented pictures leading to veridical perception (the straight series). This series is then reversed, allowing the participant to relinquish veridical perception and to reconsider his or her interpretation of the input. While this reversed series enables an assessment of creativity, the straight series enables an assessment of impulsivity. The goal of this article was to present the potential of using such a microgenetic technique to investigate both creativity and impulsivity.
Structure of the Major Peanut Allergen Ara h 1 May Protect IgE-Binding Epitopes from Degradation1

In the past decade, there has been an increase in allergic reactions to peanut proteins, sometimes resulting in fatal anaphylaxis. The development of improved methods for diagnosis and treatment of peanut allergies requires a better understanding of the structure of the allergens. Ara h 1, a major peanut allergen belonging to the vicilin family of seed storage proteins, is recognized by serum IgE from >90% of peanut-allergic patients. In this communication, Ara h 1 was shown to form a highly stable homotrimer. Hydrophobic interactions were determined to be the main molecular force holding monomers together. A molecular model of the Ara h 1 trimer was constructed to view the stabilizing hydrophobic residues in the three dimensional structure. Hydrophobic amino acids that contribute to trimer formation are at the distal ends of the three dimensional structure where monomer-monomer contacts occur. Coincidentally, the majority of the IgE-binding epitopes are also located in this region, suggesting that they may be protected from digestion by the monomer-monomer contacts. On incubation of Ara h 1 with digestive enzymes, various protease-resistant fragments containing IgE-binding sites were identified. The highly stable nature of the Ara h 1 trimer, the presence of digestion resistant fragments, and the strategic location of the IgE-binding epitopes indicate that the quaternary structure of a protein may play a significant role in overall allergenicity.
Connected component based approach for text extraction from color image

Image based text extraction is one of the fastest growing research areas in the field of multimedia technology. The extraction of text from a complex or more colorful images is a challenging problem. Text data present in images contains useful information for habitual explanation, indexing, and structuring of images. Extraction of this information involves detection, localization, tracking, extraction, enhancement, and recognition of the text from a given image. For fast extracting text from images, we have proposed a connected component based approach which identifies more accurately for small or large texts in the image. The text extraction process starts with conversion of the color image to gray scale image and then it converts the gray scale image into a binary image. Then each text region is marked and the text is extracted from the image. Finally, the extracted text is written into another gray scale image. The experimental results demonstrate that the performance of the proposed method is superior compared to some recent approaches.
COSMOLOGICAL EVOLUTION OF MASSIVE BLACK HOLES: EFFECTS OF EDDINGTON RATIO DISTRIBUTION AND QUASAR LIFETIME

A power-law time-dependent light curve for active galactic nuclei (AGNs) is expected by the self-regulated black hole growth scenario, in which the feedback of AGNs expels gas and shut down accretion. This is also supported by the observed power-law Eddington ratio distribution of AGNs. At high redshifts, the AGN life timescale is comparable with (or even shorter than) the age of the universe, which sets a constraint on the minimal Eddington ratio for AGNs on the assumption of a power-law AGN light curve. The black hole mass function (BHMF) of AGN relics is calculated by integrating the continuity equation of massive black hole number density on the assumption of the growth of massive black holes being dominated by mass accretion with a power-law Eddington ratio distribution for AGNs. The derived BHMF of AGN relics at z = 0 can fit the measured local mass function of the massive black holes in galaxies quite well, provided the radiative efficiency ∼0.1 and a suitable power-law index for the Eddington ratio distribution are adopted. In our calculations of the black hole evolution, the duty cycle of AGN should be less than unity, which requires the quasar life timescale τQ ≳ 5 × 108 years.
Response Latencies in Naming Objects

After some preliminary analysis of what is involved in naming objects, in which the possible role of classificatory systems in the memory store is discussed, it is shown experimentally that there are consistent differences between the times taken to respond to presented objects by uttering their names, variations between the performances of different individuals being outweighed by variations due to the different objects. Moreover, there is a high consistency between different individuals as to the ordering of objects in respect of their naming latencies. It is further shown that a high correlation exists between the time taken to name an object and the frequency with which its name occurs in the language as a whole, as estimated in the Thorndike-Lorge Word List. Some implications of these findings are discussed, especially with reference to possible mechanisms by which presented objects are visually identified, and the appropriate names retrieved from the “word-store. ”