Miracle-dz/UniFAR-FTUs huggingface dataset:
THE EFFECTS OF TOPIRAMATE ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED PLACE CONDITIONINGAND BEHAVIORAL SENSITIZATION IN MICE

Introduction: Topiramate is a newly anti-convulsant drug, which acts as NMDA glutamate receptor antagonist as well as the GABAB receptor agonist. It is used for physical dependence to opioids as well as cocaine, nicotine, alcohol and ecstasy dependence. In the present study attempts were made to further identification of the effects of topiramate on the acquisition and expression of morphine-induced conditioned place preference and behavioural sensitisation in mice. Methods: Male Swiss-Webster mice were used. Conditioned place preference and locomotion were assessed by an un-biased place conditioning paradigm and open filed methods. In a pilot study, the effects of morphine and topiramate on place conditioning paradigm as well as locomotion were assessed in morphine-nave animals for evaluation of effective and ineffective doses of the drugs. Different doses of topiramate were injected to the animals 30 min before each morphine injections (acquisition) or 30 min before the experiments were beginning on the test day. Results: Administration of different doses of morphine (0.5, 5 and 50 mg/kg) induced locomotor activity in the animals. In addition, morphine (1, 10 and 20 mg/kg) administration also induced place preference. On the other hand, administration of different doses of topiramate (20, 80 and 120 mg/kg) neither induced place preference nor altered animals’ activity. Topiramate administration (20 and 80 mg/kg) and (80 and 120 mg/kg) reduced the acquisition and expression of morphine-induced place preference, respectively. In addition, topiramate (20, 80 and 120 mg/kg) reduced the acquisition of morphine-induced behavioral sensitization where as the drug in dose 80 mg/kg enhanced the expression of morphine-induced behavioral sensitization. Conclusion: It can be concluded that topirmate administration interacts with the euphoric and locomotor properties of morphine and this can be considered in therapeutic usage of the drug.
Voracity and Growth Reconsidered

This article investigates economic performance when enforceable property rights are missing and subsistence needs matter. It shows that if per capita income is sufficiently high, a windfall gain in productivity triggers behavior that leads to higher growth (the normal reaction). The same shock can produce voracious behavior and lower growth when faced by poor economic agents, in particular when their productivity is low and their society is largely fractionalized. This leads to a re-assessment of the voracity effect. Economic and social performance depends no longer on character traits (the assumed curvature of the utility function) as assumed in the earlier literature. Instead, the initial degree of development, the state of technology, and the make up of society are decisive. An extension towards a two-sector economy shows that conditions for an active informal sector of low productivity are much less restrictive than originally thought.
Agricultural trade reform and poverty in Thailand: a general equilibrium analysis.

A general equilibrium modeling approach is used to estimate the effects within Thailand of unilateral and global trade liberalization, including effects on poverty incidence. It is concluded that across the board trade liberalization is poverty-reducing within Thailand, whether other countries participate in the liberalization or not. This poverty reduction occurs among both farm and non-farm households and this qualitative outcome is not dependent on the particular poverty line used in the analysis. Liberalization in agricultural products alone raises poverty incidence among farm households, while reducing it slightly among non-farm households.
No Evidence of Dehydration with Moderate Daily Coffee Intake: A Counterbalanced Cross-Over Study in a Free-Living Population

It is often suggested that coffee causes dehydration and its consumption should be avoided or significantly reduced to maintain fluid balance. The aim of this study was to directly compare the effects of coffee consumption against water ingestion across a range of validated hydration assessment techniques. In a counterbalanced cross-over design, 50 male coffee drinkers (habitually consuming 3–6 cups per day) participated in two trials, each lasting three consecutive days. In addition to controlled physical activity, food and fluid intake, participants consumed either 4×200 mL of coffee containing 4 mg/kg caffeine (C) or water (W). Total body water (TBW) was calculated pre- and post-trial via ingestion of Deuterium Oxide. Urinary and haematological hydration markers were recorded daily in addition to nude body mass measurement (BM). Plasma was analysed for caffeine to confirm compliance. There were no significant changes in TBW from beginning to end of either trial and no differences between trials (51.5±1.4 vs. 51.4±1.3 kg, for C and W, respectively). No differences were observed between trials across any haematological markers or in 24 h urine volume (2409±660 vs. 2428±669 mL, for C and W, respectively), USG, osmolality or creatinine. Mean urinary Na+ excretion was higher in C than W (p = 0.02). No significant differences in BM were found between conditions, although a small progressive daily fall was observed within both trials (0.4±0.5 kg; p<0.05). Our data show that there were no significant differences across a wide range of haematological and urinary markers of hydration status between trials. These data suggest that coffee, when consumed in moderation by caffeine habituated males provides similar hydrating qualities to water.
China and ASEAN-5 bilateral trade relationship

This paper examines the China-ASEAN bilateral trade relationship, using the Gravity model where the per capita income difference is included in the specification for testing the hypothesis. The empirical results based on Bounds test proposed by Pesaran et al. (2001) reveal that the transportation cost and real GDP are statistically significant determinants of bilateral trade. The trade distance remains an important deterrent to China-ASEAN trade, and higher economy size of a country has positive and significant influence on bilateral trade flows. The significant positive sign of the per capita GDP difference (PGDPdiff) variable suggests that Linder Hypothesis does not hold for the entire region.
Mutational analyses of the ATP 6 V 1 B 1 and ATP 6 V 0 A 4 genes in patients with primary distal renal tubular acidosis

Background. Mutations in the ATP6V1B1 and the ATP6V0A4 genes cause primary autosomal-recessive distal renal tubular acidosis (dRTA). Large deletions of either gene in patients with dRTA have not been described. Methods. The ATP6V1B1 and ATP6V0A4 genes were directly sequenced in 11 Japanese patients with primary dRTA from nine unrelated kindreds. Large heterozygous deletions were analyzed by quantitative real-time polymerase chain reaction (PCR). The clinical features of the 11 patients were also investigated. Results. Novel mutations in the ATP6V1B1 gene were identified in two kindreds, including frameshift, in-frame insertion and nonsense mutations. Large deletions in the ATP6V0A4 gene were identified in two kindreds. Exon 15 of ATP6V0A4 was not amplified in one patient, with a long PCR confirming compound heterozygous deletions of 3.7and 6.9-kb nucleotides, including all of exon 15. Direct DNA sequencing revealed a heterozygous frameshift mutation in ATP6V0A4 in another patient, with quantitative real-time PCR indicating that all exons up to exon 8 were deleted in one allele. Clinical investigation showed that four of the six patients with available clinical data presented with hyperammonemia at onset. Conclusions. To our knowledge, these dRTA patients are the first to show large deletions involving one or more entire exons of the ATP6V0A4 gene. Quantitative PCR amplification may be useful in detecting heterozygous large deletions. These results expand the spectrum of mutations in the ATP6V0A4 and ATP6V1B1 genes associated with primary dRTA and provide insight into possible structure–function relationships.
Leakage Current and Discharge Phenomenon of Outdoor Insulators

This paper descirbes leakage current characters and discharge phenomenon of outdoor insulators both in the lab and in the field. The results are hoped to be used for online monitoring of the contamination levels. The following contents are introduced in the paper: leakage current monitoring systems, relationships between leakage current and discharge phenomenon, flashover prediction methods and its applications in the field. The leakage current monitoring system is introduced firstly. Then the relationships between leakage current and discharge phenomenon for both suspension insulators and post insulators are presented based on the laboratory tests. A new parameter (I * ) that accounted for maximum leakage current (Ih) and different insulator shapes is introduced to estimate the flashover voltage for different kinds of pollutant layers when they are saturated with moisture. Meanwhile, the relationships between relative humdity (RH) and maximum leakage curren, altitude and maximum leakage current are investigated. With these results a flashover prediction method is developed. Ih measured in different relative humidity is converted to I * for the same contaminate layer when it is saturated with moisture. Then the flashover voltage is estimated by I * . Furthermore, an online leakage current monitoring results are analyzed. The relationships between leakage current characters in the field and ambient relative humidity are analyzed. The results show that although there are some differences between the leakage current in the field and in the lab because of some especially serve atmospheric conditions, the relationships are similar. Meanwhile, leakage current waveforms in different weather conditions are investigated. The waveforms of leakage current in the field are similar with those in the lab. The leakage current waveform that accounted for strong arc is found in the field. Finally, the contamination level of the field insulator is evaluated. The results corresponds well with the local condition.
UWB interference to narrowband receivers

This paper studies the in-band interference of timehopping spread spectrum (TH-SS) UWB signals to narrow band receivers. Based on the analysis of general power spectral density (PSD) of TH-SS UWB signal, the interference of UWB signal can be partitioned into two parts: (1) additive white Gaussian noise interference (2) jamming tone interference. Following this framework, a novel analytical symbol error rate (SER) evaluation method of BPSK signal due to UWB interferences is proposed. It has been found out that as the number of inband jamming tones increases, the UWB interference effect tends to be closer to the effect of equivalent Gaussian noise.
The impact of 'computer-supported collaborative inquiry' for science learning in secondary education

The present dissertation starts with a general overview of the research issues and the main concepts that are presented in Chapters 2 to 6. After a general introduction, the main research objectives challenged in this dissertation are outlined. The introduction concludes with an overview of the methodological approaches applied in each study and gives an overview of the different chapters included in this dissertation.
Eosinophilic fasciitis (Shulman disease): new insights into the therapeutic management from a series of 34 patients.

OBJECTIVE To analyse therapeutic management of eosinophilic fasciitis (EF). METHODS We reviewed 34 adult patients with biopsy-proven EF. Analyses focused on the therapeutic management, including treatment modalities, responses and associated or predictive factors. RESULTS Thirty-four patients were included with a diagnosis age of 53 (15) years. They were featured by cutaneous manifestations (88%) including morphoea (41%), myalgia (86%) and hypereosinophilia (85%). Thirty-two patients (94%) were eligible for treatment evaluation and all received CSs as a first-line therapy. Fifteen patients (47%) received methylprednisolone pulses (MPPs) at treatment initiation and 14 patients (44%) received an immunosuppressive drug (ISD), usually MTX (86%), as a second-line therapy. Complete remission was achieved for 69% of patients, remission with disability 19% and failure 12%. A poor outcome was associated with a diagnosis time delay of >6 months [odds ratio (OR) = 14.7] and the lack of MPPs (OR = 12.9). CONCLUSION Our study reports new insights into the therapeutic management of EF: (i) CS treatment remains the standard therapy for EF, taken alone or in association with an ISD; (ii) MPPs at initiation of treatment are associated with a better outcome and a lower need of ISD use; (iii) an ISD, usually MTX, might be useful as a second-line therapy, mainly in patients with morphoea-like lesions. Naturally, these practical conclusions should be confirmed by a prospective and multicentre study.
Intergenerational Transmission of Reflective Functioning

The present study investigated whether, and to what extent, reflective functioning (RF) during preadolescence is associated with maternal attachment security and RF, and with the child’s attachment security. Thirty-nine mother–preadolescent child dyads from a non-clinical population participated in the study. Maternal and child RF were assessed by applying the Reflective Functioning Scale to the Adult Attachment Interview (AAI) and to the Child Attachment Interview transcripts. Children of mothers who showed a secure attachment model regarding the relationship with their parents during childhood reported higher levels of RF than the children of mothers who were classified as insecure on the AAI. Child RF was positively associated with maternal “Coherence of the Mind” on the AAI and negatively associated with maternal derogation of attachment. A strong, significant association was also found between child attachment security and child RF. Children who were rated as being more emotionally open, more able to balance positive and negative descriptions of their parents, more prone to support their assertions through examples, and more able to positively resolve conflicts with their parents showed higher RF. On the contrary, children who resorted to a higher extent to idealization and dismissal toward their parents showed a lesser degree of RF. Notably, a very strong association was found between the score on the “Overall coherence” subscale and the child’s ability to mentalize mixed-ambivalent mental states in the context of their family relationships. As expected, child and maternal RF resulted significantly positively correlated with each other. In particular, only maternal RF (and not maternal attachment security) predicted child RF, and only maternal ability to mentalize mixed-ambivalent mental states predicted the corresponding ability in the children.
The Relations Between Personality and Language Use

The authors of this study provided basic descriptive data on the correlation between personality tests and Korean language use. Native Korean-speaking students (N = 80) at Pusan National University completed 2 personality tests, the Myers-Briggs Type Indicator (MBTI; I. B. Myers, M. H. McCaulley, N. L. Quenk, & A. L. Hammer, 1998) and the 5-Factor Inventory (O. P. John, E. M. Donahue, & R. L. Kentle, 1991). They completed a stream-of-consciousness essay, which the authors analyzed using the Korean version of Linguistic Inquiry and Word Count (KLIWC; C. H. Lee, J. Shim, & A. Yoon, 2005). Personality traits were significantly correlated with linguistic variables. Furthermore, the observed correlations between the two types of variables in Korean were consistent with the results of previous LIWC studies conducted in English. The authors discuss language use as a marker of personality.
It’s only a matter of confidence! A comparison of relationship management between Japanese‐ and UK non‐Japanese‐owned vehicle manufacturers

Attempts to answer the question: why are Japanese firms better at managing long‐term supplier relationships? Discusses the results from a three‐year research project that focuses on the way in which Japanese transplants and UK non‐Japanese‐owned vehicle manufacturers manage their relationships. The research attempts to define the concept of trust, by using existing academic models. Using the existing literature examines how Japanese and non‐Japanese‐owned (UK) manufacturers work with their first tier suppliers. The research is primarily qualitative due to the small sample size of non‐Japanese‐owned and Japanese vehicle manufacturers; however, the research does examine five vehicle manufacturers and 19 relationships. Concludes with the development of a conceptual model for mutually advantageous business relationships, which is an attempt to produce a workable inventory of trust for use by both customers and suppliers.
Relation of hospital volume to colostomy rates and survival for patients with rectal cancer.

BACKGROUND Postoperative mortality after some types of cancer surgery is inversely related to the number of operations performed at a hospital (i.e., hospital volume). This study assessed the association of hospital volume with colostomy rates and survival for patients with rectal cancer in a large representative cohort identified from the California Cancer Registry. METHODS We identified 7257 patients diagnosed from January 1, 1994, through December 31, 1997, with stage I-III rectal cancer who underwent surgical resection. Registry data were linked to hospital discharge abstracts and ZIP-code-level data from the 1990 U.S. Census. Associations of hospital volume with permanent colostomy and 30-day mortality were assessed with the Mantel-Haenszel trend test and logistic regression. Overall survival was examined with the Kaplan-Meier method and a multivariable Cox proportional hazards model. Multivariable analyses adjusted for demographic and clinical variables and patient clustering within hospitals. All tests of statistical significance were two-sided. RESULTS In unadjusted analyses across decreasing quartiles of hospital volume, we observed statistically significant increases in colostomy rates (29.5%, 31.8%, 35.2%, and 36.6%; P<.001) and in 30-day postoperative mortality (1.6%, 1.6%, 2.9%, and 4.8%; P<.001) and a decrease in 2-year survival (83.7%, 83.2%, 80.9%, and 76.6%; P<.001). The adjusted risks of permanent colostomy (odds ratio [OR] = 1.37, 95% confidence interval [CI] = 1.10 to 1.70), 30-day mortality (OR = 2.64, 95% CI = 1.41 to 4.93), and 2-year mortality (hazard ratio = 1.28, 95% CI = 1.15 to 1.44) were greater for patients at hospitals in the lowest volume quartile than for patients at hospitals in the highest volume quartile. Stratification by tumor stage and comorbidity index did not appreciably affect the results. Adjusted colostomy rates varied statistically significantly (P<.001) among individual hospitals independent of volume. CONCLUSIONS Rectal cancer patients who underwent surgery at high-volume hospitals were less likely to have a permanent colostomy and had better survival rates than those treated in low-volume hospitals. Identifying processes of care that contribute to these differences may improve patients' outcomes in all hospitals.
Peripheral Glutamate Receptors Are Required for Hyperalgesia Induced by Capsaicin

Transient receptor potential vanilloid1 (TRPV1) and glutamate receptors (GluRs) are located in small diameter primary afferent neurons (nociceptors), and it was speculated that glutamate released in the peripheral tissue in response to activation of TRPV1 might activate nociceptors retrogradely. But, it was not clear which types of GluRs are functioning in the nociceptive sensory transmission. In the present study, we examined the c-Fos expression in spinal cord dorsal horn following injection of drugs associated with glutamate receptors with/without capsaicin into the hindpaw. The subcutaneous injection of capsaicin or glutamate remarkably evoked c-Fos expression in ipsilateral sides of spinal cord dorsal horn. This capsaicin evoked increase of c-Fos expression was significantly prevented by concomitant administration of MK801, CNQX, and CPCCOEt. On the other hand, there were not any significant changes in coinjection of capsaicin and MCCG or MSOP. These results reveal that the activation of iGluRs and group I mGluR in peripheral afferent nerves play an important role in mechanisms whereby capsaicin evokes/maintains nociceptive responses.
Differential Patterns of Infection and Disease with P. falciparum and P. vivax in Young Papua New Guinean Children

Background Where P. vivax and P. falciparum occur in the same population, the peak burden of P. vivax infection and illness is often concentrated in younger age groups. Experiences from malaria therapy patients indicate that immunity is acquired faster to P. vivax than to P. falciparum challenge. There is however little prospective data on the comparative risk of infection and disease from both species in young children living in co-endemic areas. Methodology/Principal Findings A cohort of 264 Papua New Guinean children aged 1-3 years (at enrolment) were actively followed-up for Plasmodium infection and febrile illness for 16 months. Infection status was determined by light microscopy and PCR every 8 weeks and at each febrile episode. A generalised estimating equation (GEE) approach was used to analyse both prevalence of infection and incidence of clinical episodes. A more pronounced rise in prevalence of P. falciparum compared to P. vivax infection was evident with increasing age. Although the overall incidence of clinical episodes was comparable (P. falciparum: 2.56, P. vivax 2.46 episodes / child / yr), P. falciparum and P. vivax infectious episodes showed strong but opposing age trends: P. falciparum incidence increased until the age of 30 months with little change thereafter, but incidence of P. vivax decreased significantly with age throughout the entire age range. For P. falciparum, both prevalence and incidence of P. falciparum showed marked seasonality, whereas only P. vivax incidence but not prevalence decreased in the dry season. Conclusions/Significance Under high, perennial exposure, children in PNG begin acquiring significant clinical immunity, characterized by an increasing ability to control parasite densities below the pyrogenic threshold to P. vivax, but not to P. falciparum, in the 2nd and 3rd year of life. The ability to relapse from long-lasting liver-stages restricts the seasonal variation in prevalence of P. vivax infections.
Differential susceptibility to rearing experience: the case of childcare.

BACKGROUND Inconsistencies regarding developmental effects of non-maternal childcare may be caused by neglecting the possibility that children are differentially susceptible towards such experiences. METHOD Interactions between difficult/negative child temperament and childcare type, quantity, and quality on teacher-rated behavior problems and social competence at 54 months and in kindergarten were investigated via multiple regression using data from the NICHD Study of Early Child Care. RESULTS Childcare quality interacted with infant negativity in predicting behavior problems and social competence, whereas effects of quantity and type were independent of child temperament. Consistent with Belsky's (1997) differential susceptibility hypothesis, children with difficult temperaments as infants exhibited both more behavior problems when faced with low quality care and fewer when experiencing high quality care than children with easy temperaments. CONCLUSIONS Negatively-emotional infants appear to be more affected by the quality of care they experience - both negatively and positively - than other young children.