Miracle-dz/UniFAR-FTUs huggingface dataset:
CREATING CONTEXT – ENTREPRENEURIAL OPPORTUNITIES IN A CONSUMER MARKET SETTING

This paper focuses on entrepreneurial opportunities in a consumer market setting. The purpose is to explore how the corporate branding process influences emerging entrepreneurial opportunities. The empirical results show the importance of symbols and images influencing emerging opportunities, rather than isolated product innovations. Here the importance of examining all the people involved in the entrepreneurial process, rather than just focusing on the entrepreneur or the entrepreneurial organization, is emphasized. The case illustrates the intensity and the devotion invested in the creation of a context that holds the Nav products. In this process the interplay between identity and image is described in a corporate branding perspective. I show how, by whom, and where, the creation of context becomes distinct. Introducing the creation of context to entrepreneurship theories change the opportunity discussion from a situation where organizational aspects are primarily focused on, to a situation also emphasizing the consumer market side of entrepreneurial opportunities. The theoretical results illustrate how branding theory and marketing/entrepreneurship interface theories shift the interest from organization aspects to market related aspects of the entrepreneurial process. The overall conclusions are that branding aspects of the entrepreneurial process are becoming more challenging in a society and on a market generally characterized by fragmentation.
Resilience, panarchy and customary structures in Afghanistan

‘Fragile’ and ‘failed state’ discourse leads to a reductionist portrayal of failure that can obscure the presence of patterns of resilience. This paper examines the role of resilience theory, and one of its derivations, ‘panarchy’, in relation to the restorative agency of communities, simultaneous fragmentation and positive adaptation across multiple connected systems in Afghanistan. The results suggest that the resilience of Afghan communities to conflict and violence has depended on the durability of both their positive and negative adaptive strategies in providing a range of public services to fill in the void left by government. While customary structures have been sources of order and solidarity at the local level, they have also fomented destabilisation and frustrated the extension of the neoliberal governmentality and the securitisation agendas. Customary affiliations have adapted in multiple and overlapping ways, demonstrating a high level of community resilience in the face of widespread disruption brought about by conflict.
In-hospital and mid-term clinical outcomes after percutaneous coronary intervention with the use of sirolimus- or paclitaxel-eluting stents.

BACKGROUND Drug-eluting stents improved the outcome after percutaneous coronary intervention (PCI), however, there may be significant differences in their safety and efficacy. AIM To compare the in-hospital and mid-term clinical outcomes of stenting with sirolimus-eluting stents (SES) versus paclitaxel-eluting stents (PES) for the treatment of coronary artery lesions in our routine practice. METHODS This study was performed on 1311 consecutive patients treated exclusively either with SES or PES in our hospital between March 2003 and March 2007. Patients with acute myocardial infarction (MI) within the preceding 48 hours were excluded. The data were recorded in our computerised database, and analysed with appropriate statistical methods. RESULTS The frequency of angulated segments and proximal segment tortuosity was higher in the PES group (p = 0.001 and p < 0.001, respectively), while ostial and left anterior descending artery lesions were more frequently treated with SES (p < 0.001 and p = 0.022, respectively). The rate of in-hospital non-Q wave MI was higher in the SES vs. PES group (2.2 vs. 0.7%, p = 0.039). In multivariate analysis, the relationship between type of stent and in-hospital non-Q-wave MI became less significant (p = 0.083). During follow-up, 5 patients in the SES vs. 3 in the PES group died (0.7% in each group, p = 0.749). The frequency of major adverse cardiac events (MACE) and target vessel revascularisation (TVR) in the SES vs. PES group was similar (5.5 vs. 3.3%, p = 0.138, and 2.9 vs. 1.6%, p = 0.213, respectively). In multivariate analysis, reference vessel diameter was an independent predictor of both TVR (HR = 0.170, 95% CL 0.034-0.837, p = 0.029) and MACE (HR = 0.333, 95% CL 0.120-0.925, p = 0.035). CONCLUSION During mid-term follow-up, sirolimus-eluting stents and paclitaxel-eluting stents demonstrate similar clinical outcomes.
Research area selection in academic departments

The paper treats the topic of long range planning in an applied research oriented university unit. The advantages and disadvantages of the relevance of planning in an academic frame are considered, and the need for a formal long-term consideration of the development of an academic research unit is presented. Endogenous and exogenous attributes of future desirable fields of research are determined. The desired attributes are translated into selection criteria and quantitative indicators. A compensatory type methodology for decision-making is applied in order to rank potential areas of research. An example of the application of the proposed methodology for selecting directions of development for an applied chemistry academic unit (Casali Institute of Applied Chemistry, The Hebrew University of Jerusalem) is presented and the results are discussed.
Disease-related factors associated with health-related quality of life in people with nonadvanced HIV disease assessed using an Italian version of the MOS-HIV Health Survey.

OBJECTIVE This study was intended to present evidence for the reliability and validity of an Italian version of the MOS-HIV Health Survey and to identify important disease-related factors associated with health-related quality of life (HRQoL) in people with nonadvanced HIV. DESIGN In this cross-sectional study, HRQoL was measured using an Italian version of the MOS-HIV Health Survey questionnaire in 213 HIV-infected people without previous opportunistic infections or neoplasms attending an outpatient clinic in a university hospital. Distribution of scores, reliability, and validity were calculated, and presence and frequency of HIV-related symptoms were recorded and transformed into a score. The relation of HRQoL values to sociodemographic, epidemiologic, and clinical data was assessed. RESULTS The level of internal consistency of the Italian version of the MOS-HIV Health Survey was high (Cronbach's alpha, 0.80-0.93), and items demonstrated acceptable discrimination across scales. At linear regression analysis, all domains of HRQoL correlated with symptom score (r2 range, 0.07-0.41), but only the pain and physical-functioning scores showed a significant correlation with CD4 cell count. A weighted sum of single domains of HRQoL, TOTQoL, is also strongly correlated with symptom score (r2 = 0.57; p < .0001) but not with CD4 cell count (r2 = 0.01; p = .1). Using multivariate analysis, only symptom score (p < .0001) and total number of daily pills (p = .03) showed significant association with HRQoL. The same results were observed when analysis was performed only on people with CD4 levels <200/microl. CONCLUSIONS This study presents the first evidence for the reliability and validity of a HRQoL instrument in Italian for people with HIV. Results also suggest a strong impact of symptoms on all measured dimensions of health status. The number of pills required to be taken daily is the only other significant factor associated with a lower HRQoL, whereas no relations were found with CD4 cell count or Karnofsky performance status values. To improve HRQoL in persons with nonadvanced HIV disease, symptom control could be a crucial element of medical treatment.
Balancing Environmental Flows Needs and Water Supply Reliability

This paper describes an approach to the integration of environmental flows recommendations into water resources planning, and demonstrates its application to a case study in the Jiaojiang Basin, Taizhou, Zhejiang Province, the People's Republic of China. In this approach, environmental flows recommendations were provided to the process as a preferred regime, and also as one or more sub-optimal regimes. A risk assessment approach was used to derive the sub-optimal regimes from the preferred regime. The environmental flows rules were then incorporated into a wider water resources model which allowed testing of any number of development scenarios. The model-predicted daily time series' of river flows were passed through a sophisticated form of spells analysis to evaluate the degree of compliance with a specified environmental flows regime. This degree of compliance was balanced against the predicted security of supply to water users. This integrated approach allowed for a greater appreciation of environmental concerns by planners. It also provided an opportunity to the scientists who undertook the environmental flows assessment to contribute to the process of making rational trade-offs between risks to the environment and gains in security of supply.
An emerging role for class I bHLH E2-2 proteins in EMT regulation and tumor progression

EMT is a complex process whereby cells lose cell-cell interactions and other epithelial properties whilst acquiring a migratory and mesenchymal phenotype. EMT is presently recognized as an important even for tumour invasion and metastasis. Functional Ecadherin loss is a hallmark of EMT and required for tumour invasion in the majority of carcinomas. Transcriptional downregulation is one of the major mechanisms for Ecadherin suppression in carcinomas. In the last decade several E-cadherin repressors, belonging to different transcriptional families, have been identified that, importantly, also act as potent EMT inducers. One of the last additions to EMT regulators are the class I bHLH factors E2-2 (also known as TCF4). However, the hierarchical and functional interrelations between the different EMT inducers are still poorly understood. Here, we comment on the new and so far unrecognized function of E2-2 factors in EMT and discuss on the potential interactions among various EMT inducers. Emerging evidence supporting the participation of TCF4 in human malignancies is also discussed. Thus, increasing understanding of EMT and its regulators is providing meaningful insights into the present knowledge on tumour progression.
Regulation of Banking and Banks Governance: When Liquidity Drives Financial Behavior

This paper presents a dynamic approach to liquidity based on uncertainty as conceptualised by Knight, developed in a theory of long-term expectations by Keynes, and applied to banking by Minsky. This perspective reveals that banks perform maturity transformation and create monetary liabilities by overcoming uncertainty about the future based on generally accepted conventions of safety. When uncertainty returns to the forefront, acceptance of private money is compromised and a liquidity crisis may ensue. On this basis, the paper illustrates how banking should be regulated ex-ante and supported ex-post by central banks in order to reduce financial instability. Regulation and the safety net should be complemented by corporate governance committing bank managers to long-term horizons. Rules on managerial remuneration are insufficient for this purpose. Insulating bankers from market pressure for high- risk, high-returns strategies should be allowed too.
Noncontiguous fractures of the femoral neck, femoral shaft, and distal femur.

BACKGROUND Multifocal fractures of the femur are uncommon injuries and present unique management challenges. Combined ipsilateral fractures of the femoral shaft and femoral neck or the femoral shaft and distal femur have been described. The combination of noncontiguous ipsilateral femoral neck, femoral shaft, and distal femoral articular injuries, however, has not been described. The purposes of this report are to document the incidence and characteristics of this injury and to present a treatment rationale. METHODS This was a retrospective study conducted at a Level I trauma center. RESULTS Over a 5-year period, 1639 adult patients with femur fractures were definitively managed at the authors' institution. Five male and two female patients (average age, 43.3 years) sustained ipsilateral, noncontiguous fractures of the femoral neck, femoral shaft, and distal femoral articular surface (0.43%). All femoral neck fractures were vertically oriented. All distal femoral injuries were unicondylar. A variety of fixation methods were used, dependent on individual fracture characteristics. The femoral neck fractures were prioritized in all cases. Stabilization of the distal femoral articular surface was then performed before diaphyseal fixation in patients with sagittally oriented condylar fractures. Patients were followed for an average of 19.3 months. All fractures healed without the need for secondary procedures. CONCLUSION This injury constellation is rare. Open reduction and internal fixation of the displaced femoral neck fracture should be the primary focus of orthopedic management, followed by stable reduction and fixation of displaced distal femoral articular injuries. The diaphyseal fracture should be treated with a technique that does not jeopardize either the proximal or the distal fractures. Patients who are critically ill can be managed in a similar sequence over the course of several days, depending on their overall condition.
Classification With Ant Colony Optimization

Ant colony optimization (ACO) can be applied to the data mining field to extract rule-based classifiers. The aim of this paper is twofold. On the one hand, we provide an overview of previous ant-based approaches to the classification task and compare them with state-of-the-art classification techniques, such as C4.5, RIPPER, and support vector machines in a benchmark study. On the other hand, a new ant-based classification technique is proposed, named AntMiner+. The key differences between the proposed AntMiner+ and previous AntMiner versions are the usage of the better performing MAX-MIN ant system, a clearly defined and augmented environment for the ants to walk through, with the inclusion of the class variable to handle multiclass problems, and the ability to include interval rules in the rule list. Furthermore, the commonly encountered problem in ACO of setting system parameters is dealt with in an automated, dynamic manner. Our benchmarking experiments show an AntMiner+ accuracy that is superior to that obtained by the other AntMiner versions, and competitive or better than the results achieved by the compared classification techniques.
Cell Factors Stimulate Human Immunodeficiency Virus Type 1 Reverse Transcription In Vitro

ABSTRACT After fusion of the human immunodeficiency virus type 1 (HIV-1) envelope with the host cell membrane, the HIV-1 core enters the cell cytoplasm. Core components are then restructured to form the reverse transcription complex (RTC); the biochemical details of this process are currently unclear. To investigate early RTC formation, we characterized the endogenous reverse transcription activity of virions, which was less efficient than reverse transcription during cell infection and suggested a requirement for a cell factor. The addition of detergent to virions released reverse transcriptase and capsid, and reverse transcription products became susceptible to the action of exogenous nucleases, indicating virion disruption. Disruption was coincident with the loss of the endogenous reverse transcription activity of virions, particularly late reverse transcription products. Consistent with this observation, the use of a modified “spin thru” method, which uses brief detergent exposure, also disrupted virions. The addition of lysates made from mammalian cell lines (Jurkat, HEK293T, and NIH 3T3 cells) to virions delipidated by detergent stimulated late reverse transcription efficiency. A complex with reverse transcription activity that was slower sedimenting than virions on a velocity gradient was greatly stimulated to generate full-length reverse transcription products and was associated with only relatively small amounts of capsid. These experiments suggest that cell factors are required for efficient reverse transcription of HIV-1.
Mortality Differentials by Marital Status: An International Comparison

Although the greater longevity of married people as compared with unmarried persons has been demonstrated repeatedly, there have been very few studies of a comparative nature. We use log-linear rate models to analyze marital-status-specific death rates for a large number of developed countries. The results indicate that divorced persons, especially divorced men, have the highest death rates among the unmarried groups of the respective genders; the excess mortality of unmarried persons relative to the married has been generally increasing over the past two to three decades; and divorced and widowed persons in their twenties and thirties have particularly high risks of dying, relative to married persons of the same age. In addition, the analysis suggests that a selection process is operating with regard to single and divorced persons: the smaller the proportion of persons who never marry or who are divorced, the higher the resulting death rates.
Differences in DNA Binding Characteristics of the Androgen and Glucocorticoid Receptors Can Determine Hormone-specific Responses*

The basis for specificity of gene regulation by steroid hormone receptors remains an important problem in the study of steroid hormone action. One possible mechanism for steroid specificity is the difference in DNA binding characteristics of the receptors, although they share a high homology in their DNA-binding domains. Indeed, the androgen-specific expression of, for example, the probasin (PB) gene can be explained by the presence of an androgen response element (ARE) in its promoter (PB-ARE-2), specifically recognized by the androgen and not by the glucocorticoid receptor. Three residues in the DNA-binding domain of the AR were identified as main determinants for its high affinity for the PB-ARE-2. In addition, the direct repeat nature of this ARE seems to prohibit high affinity binding by the glucocorticoid receptor. This is confirmed by the fact that several imperfect direct repeats of the 5′-TGTTCT-3′ core recognition sequence are recognized by the androgen receptor and not by the glucocorticoid receptor. Up to now, only differences between the androgen and glucocorticoid receptor in the transcription activation functions were invoked to explain the specificity of their genomic actions. In the present study, we describe the influence of the DNA-binding domain on the specificity of androgen action. The novelty of our working hypothesis resides in the demonstration of the capacity of the AR-DNA-binding domain to recognize elements with a direct repeat structure.
Tanzania's Equilibrium Real Exchange Rate

Tanzania's real effective exchange rate (REER) has depreciated sharply since end-2000, reversing the appreciation that took place in the second half of the 1990s. Single-country and panel data estimates, and the external sustainability approach, suggest that Tanzania's REER is currently modestly undervalued relative to its estimated equilibrium level. Looking forward, a modest trend appreciation of the equilibrium REER is expected, consistent with continued high GDP growth and an expected recovery in terms of trade. In addition, capital inflows to Tanzania could be significantly higher than currently expected, to take advantage of Tanzania's natural resources and strong policy framework. If so, these inflows would contribute to an additional appreciation by as much as 20 percent of the equilibrium REER.
Molecular dynamics studies of native and substituted cyclodextrins in different media: 1. Charge derivation and force field performances.

Molecular dynamics simulations describing the solvation process of native and modified cyclodextrins (per-substituted α-, β-, and γ-cyclodextrins, as well as an amino-acid derived β-cyclodextrin) have been performed. A homogeneous force field, namely "q4md-CD", has been built from the development of a new force field topology database and from a combination of the GLYCAM04 and Amber99SB force fields to correctly describe the geometrical, structural, dynamical and hydrogen bonding aspects of heterogeneous cyclodextrin based systems. These include native, organo- and peptidic-linked cyclodextrins. q4md-CD features: (i) geometrical parameters from Amber99SB to describe the protein parts, (ii) geometrical parameters from GLYCAM04 for the carbohydrate and organic parts when available or those of Amber99SB otherwise, (iii) partial atomic charges, embedded in force field libraries for the carbohydrate and organic fragments, were derived using the R.E. D. tools according to the "Amber" strategy and (iv) scaling factors of 1.2 and 2.0 were imposed for the 1-4 electrostatic and 1-4 van der Waals interactions, respectively. Results given by q4md-CD on native cyclodextrins have been compared to those obtained with reference to force fields like GLYCAM04, GLYCAM06 and Amber99SB as well as with experimental data. This work not only gives a global view of the performances of the aforementioned force fields towards a correct description of solvated cyclodextrins, but also extends the capabilities of current force fields by addressing some issues concerning hydrogen bonding and opens new possibilities towards studies of glycoconjugates by molecular dynamics.
A New Approach to Markov-Switching GARCH Models

The use of Markov-switching models to capture the volatility dynamics of financial time series has grown considerably during past years, in part because they give rise to a plausible interpretation of nonlinearities. Nevertheless, GARCH-type models remain ubiquitous in order to allow for nonlinearities associated with time-varying volatility. Existing methods of combining the two approaches are unsatisfactory, as they either suffer from severe estimation difficulties or else their dynamic properties are not well understood. In this article we present a new Markov-switching GARCH model that overcomes both of these problems. Dynamic properties are derived and their implications for the volatility process discussed. We argue that the disaggregation of the variance process offered by the new model is more plausible than in the existing variants. The approach is illustrated with several exchange rate return series. The results suggest that a promising volatility model is an independent switching GARCH process with a possibly skewed conditional mixture density. Copyright 2004, Oxford University Press.
Statistical Properties of Two Teststhat Use Multilocus Data Sets to Detect Population Expansions

We describe two methods for detecting population expansions based on variation at unlinked microsatellite loci. The tests were first used in a study of human demographic history that showed evidence for a Paleolithic human population expansion in Africa. Here, we provide a simple recipe for applying the tests to other data sets and describe the power of the tests as a function of the sample size, number of loci, mutation rate, diploid population size N0, and time since expansion. An important property of the tests is that as long as the population doubles at least once every 0.1N0 generations, where N0 now represents the pre-expansion population size, and the overall factor of expansion is sufficiently large, the signal of growth will be nearly identical to one generated by a sudden and massive expansion. This greatly simplifies the mathematical modeling necessary to evaluate the test results but also means that many patterns of growth will be indistinguishable using the tests. A second conclusion from our analysis is that the tests show different sensitivities to specific deviations from the biological and demographic models. Hence, more information can be garnered from the two tests taken together than from either alone.