Miracle-dz/UniFAR-FTUs huggingface dataset:
Crafting Theory to Satisfy the Requirements of Interpretation

Just as Lee, Briggs, and Dennis [8] showed that positivism's conception of "explanation" leads to requirements for positivist theory to satisfy, we show that a hermeneutical conception of "interpretation" leads to requirements for interpretive theory to satisfy. We refer to the hermeneutical philosopher Ricoeur's model of the text, by which "the methodology of text-interpretation [serves] as a paradigm for interpretation in general" [12, p. 91]. Much as the meaning of a text is interpreted, the meaning of a person's action is interpreted, where in both cases, the object of interpretation is an existing understanding. It exists in the form of not only the understanding originating with the author of a text or the person engaging in an action, but also the understanding that the observing interpretive researcher comes to hold -- the interpretation. Explicit recognition of understanding in such forms leads to requirements that can strengthen interpretive theorizing.
Investigating biofilm production, coagulase and hemolytic activity in Candida species isolated from denture stomatitis patients.

OBJECTIVE Oral candidiasis, in the form of Candida-associated denture stomatitis, represents a common disease in a large percentage of denture wearers, and Candida albicans remains the most commonly isolated species. In this study, we aimed to evaluate biofilm production, coagulase and hemolytic activity of Candida species isolated from denture stomatitis patients. MATERIALS AND METHODS This study included 70 patients (31 female, 39 male). Forty-eight of the patients were found to have a positive culture. A total of 48 Candida isolates representing five species, C. albicans (n=17), C. glabrata (n=10), C. krusei (n=9), C. kefyr (n=7) and C. parapsilosis (n=5), were tested. Their coagulase activities were evaluated by a classical tube coagulase test with rabbit plasma. A blood plate assay on 3% enriched sheep blood Sabouraud-dextrose agar (SDA) was used to determine their in vitro hemolytic activities. Biofilm production was determined by a visual tube method. RESULTS Twenty-one Candida isolates exhibited coagulase activity, and the coagulase activities of the C. albicans (64.7%) isolates were higher than other species. C. albicans, C. glabrata, C. kefyr and C. krusei species demonstrated beta hemolysis. C. parapsilosis strains failed to demonstrate any hemolytic activities. Fifteen (88.0%) of the C. albicans strains were biofilm positive. Six (35.2%) of these strains were strongly positive, 8 (47.0%) C. albicans strains were moderately positive and 1 (5.8%) C. albicans strain was weakly positive. Sixteen (51.6%) of the non-albicans Candida strains were biofilm positive while 15 (48.3%) did not produce biofilms. CONCLUSION The results of this present study indicate coagulase, hemolytic activity and biofilm production by Candida spp. isolated from patients with denture stomatitis. Investigations of these virulence factors might be helpful in gaining information about the possible virulence of oral Candida species related to denture stomatitis.
Diabetic kidney disease: world wide difference of prevalence and risk factors

Diabetic kidney disease – which is defined by elevated urine albumin excretion or reduced glomerular filtration rate (GFR) or both – is a serious complication that occurs in 20% to 40% of all diabetics. In this review we try to highlight the prevalence of diabetic nephropathy which is not uncommon complication of diabetes all over the world. The prevalence of diabetes worldwide has extended epidemic magnitudes and is expected to affect more than 350 million people by the year 2035. There is marked racial/ethnic besides international difference in the epidemiology of diabetic kidney disease which could be explained by the differences in economic viability and governmental infrastructures. Approximately one-third of diabetic patients showed microalbuminuria after 15 years of disease duration and less than half develop real nephropathy. Diabetic kidney disease (DKD) is more frequent in African-Americans, Asian-Americans, and Native Americans. Progressive kidney disease is more frequent in Caucasians patients with type 1 than type 2 diabetes mellitus (DM), although its overall prevalence in the diabetic population is higher in patients with type 2 DM while this type of DM is more prevalent. Hyperglycemia is well known risk factor for in addition to other risk factors like male sex, obesity, hypertension, chronic inflammation, resistance to insulin, hypovitaminosis D, and dyslipidemia and some genetic loci and polymorphisms in specific genes. Management of its modifiable risk factors might help in reducing its incidence in the nearby future.
Pluribus Unum : Framing , Matching , and Form Emergence in U . S . Television Broadcasting , 1940 – 1960 Fabrizio Perretti

Recent research holds that new organizational forms emerge from the identity of candidate organizations that enter a domain. In this study we argue that emergence of a new form, which is ultimately based on validation by external audiences, depends on two mechanisms: identity framing, i.e., how audiences perceive and frame the identity of an emerging organizational domain, and identity matching, i.e., the match between the identity of the domain and the identity of candidates. Accordingly, form emergence is best characterized as contextual rather than as an inherent attribute of the categories of candidate organizations. Using data on the U.S. commercial television industry from 1940 to 1960, we explore how entry rates of TV stations were affected by audiences’ expectations about the identity of the nascent domain and by the densities of organizations with different origins. We find evidence that focused expectations expressed through public discourse about media, and the number of stations coming from radio broadcasting increased entry rates. We reconcile our findings with existing theory on the emergence of organizational forms by pointing to the joint relevance of domain-related and candidate-related identities.
Mitochondrial DNA variation, phylogeography and population structure of the Asian elephant

We report the first genetic analysis of free-ranging Asian elephants (Elephas maximus). We sampled 118 elephants from Sri Lanka, Bhutan/North India, and Laos/Vietnam by extracting DNA from dung, PCR amplifying and sequencing 630 nucleotides of mitochondrial DNA, including part of the variable left domain of the control region. Comparison with African elephant (Loxodonta africana) sequences indicated a relatively slow molecular clock in the Proboscidea with a sequence divergence of ≈1%/Myr. Genetic diversity within Asian elephants was low, suggesting a small long-term effective population size. Seventeen haplotypes were identified within Asian elephants, which clustered into two well-differentiated assemblages with an estimated Pliocene divergence of 2.5–3.5 million years ago. The two assemblages showed incomplete geographical partitioning, suggesting allopatric divergence and secondary admixture. On the mainland, little genetic differentiation was observed between elephant populations of Bhutan and India or Laos and Vietnam. A significant difference in haplotype frequencies but relatively weak subdivision was observed between the regions Bhutan–India and Laos–Vietnam. Significant genetic differentiation was observed between the mainland and Sri Lanka, and between northern, mid-latitude and southern regions in Sri Lanka.
Evaluating historical drought characteristics simulated in CORDEX East Asia against observations

This study aims to understand how well regional climate models (RCMs) reproduce the observed characteristics of droughts based on the standardized precipitation evapotranspiration index (SPEI) over East Asia. While RCMs from CORDEX East Asia have been evaluated in terms of the mean and extreme values of precipitation and air temperature in the literature, their performance based on drought characteristics has not been revealed. Therefore, we investigate the temporal characteristics, such as the trend and stationarity, and other drought measures, such as the drought frequency, duration, severity and spatial extent, to determine how well these factors are captured and how they vary among the different models, including four RCMs, their ensemble mean and a driving general circulation model (GCM). The results are compared to a 26‐year observational dataset (1980 to 2005) from APHRODITE. Based on our analyses of the results, the specific findings are as follows. First, based on Mann–Kendall (MK) trend tests, the SPEI shows decreasing trends over the northern part of the domain and no trends in other regions, and these tendencies are captured by a limited number of RCMs. Notably, these trends were not captured by the ensemble mean of RCMs. Second, based on the Phillips–Perron stationarity test, stationarity is dominant in most regions based on both the observations and the RCMs. Third, the frequency decreases with increasing duration in all regions. This tendency is generally captured in the models to varying extents. Fourth, the drought severity decreases with increasing duration in all cases, as expected. However, the drought severity diverges markedly among the RCMs. Finally, estimates of the spatial extent using the RCMs are generally accurate in wet regions but inaccurate in dry regions. Furthermore, the spatial extents of the droughts diverge among the RCMs, and the models fail to accurately capture drought events with large spatial scales.
Booms and Busts in Latin America: The Role of External Factors

This paper analyzes the relevance of external factors in average quarterly GDP growth for 1990-2006 in the seven largest Latin American countries (LAC7). Modeling the relationship between LAC7 GDP and several external factors, it is found that those factors account for a significant share of variance in LAC7 GDP growth, and that external shocks produce significant responses. Likewise, a significant share of recent LAC7 growth performance can be explained by an external factor “tailwind. ” Also evaluated is the impact of deterioration in external financial conditions. Finally, the relevance of these findings for policy evaluation is emphasized. Growth performance, the strength or weakness of macroeconomic fundamentals and the impact of domestic macro and micro policies on growth can only be properly appraised by first filtering out the effects of external factors.
A fast approach for the path planning of telerobotic manipulators

A fast procedure for the robust path planning of telerobotic manipulators is presented. The approach is based on solving a linear system of equations taking into account a null space vector for obstacle avoidance, and an original scheme for the appropriate perturbation of the pseudoinverse matrix. This method allows the simultaneous pursuit of both obstacle avoidance and singularities prevention on-line in a sensor based environment. <<ETX>>
Direct Phenotypical and Functional Dysregulation of Primary Human B Cells by Human Immunodeficiency Virus (HIV) Type 1 In Vitro

Background Human immunodeficiency virus type 1 (HIV-1) induces a general dysregulation of immune system. Dysregulation of B cell compartment is generally thought to be induced by HIV-related immune activation and lymphopenia. However, a direct influence of HIV-1 particles on B cells was recently proposed as the third pathway of B cells dysregulation. Methods/Principal Findings We evaluated the direct and specific consequences of HIV-1 contact on activation, survival, proliferation and phenotype of primary B cells in vitro. Moreover, we examined expression of activation-induced cytidine deaminase (AID) mRNA that is responsible for class switch recombination (CSR) and somatic hypermutation (SHM). Here, we report that changes observed in cellular proliferation, phenotypes and activation of B cells could be caused by direct contact between HIV-1 particles and primary B cells in vitro. Finally, direct HIV-1-derived B cells activation led to the increase of AID mRNA expression and its subsequent CSR function was detected in vitro. Conclusion/Significance We showed that HIV-1 could directly induce primary B cells dysregulation triggering phenotypical and functional abilities of B cells in vitro that could explain in some extent early B-cell abnormalities in HIV disease.
Morphological, Photosynthetic, and Physiological Responses of Rapeseed Leaf to Different Combinations of Red and Blue Lights at the Rosette Stage

Rapeseed (Brassica napus L.) is sensitive to light quality. The factory production of rapeseed seedlings for vegetable use and for transplanting in the field requires an investigation of the responses of rapeseed to light quality. This study evaluated the responses of the leaf of rapeseed (cv. “Zhongshuang 11”) to different ratios of red-photonflux (RPF) and blue-photonflux (BPF) from light emitting diodes (LEDs). The treatments were set as monochromatic lights, including 100R:0B% and 0R:100B%, and compound lights (CLs), including 75R:25B%, 50R:50B%, and 25R:75B%. The total photonflux in all of the treatments was set as 550 μmolm−2s−1. With an increase of BPF, the rapeseed leaves changed from wrinkled blades and down-rolled margins to flat blades and slightly up-rolled margins, and the compact degree of palisade tissue increased. One layer of the cells of palisade tissue was present under 100R:0B%, whereas two layers were present under the other treatments. Compared to 100R:0B%, 0R:100B% enhanced the indexes of leaf thickness, leaf mass per area (LMA), stomatal density, chlorophyll (Chl) content per weight and photosynthetic capacity (Pmax), and the CLs with high BPF ratios enhanced these indexes. However, the 100R:0B% and CLs with high RPF ratios enhanced the net photosynthetic rate (Pn). The leaves under the CLs showed growth vigor, whereas the leaves under 100R:0B% or 0R:100B% were stressed with a low Fv/Fm (photosynthetic maximum quantum yield) and a high content of O2. - and H2O2. The top second leaves under 100R:0B% or 0R:100B% showed stress resistance responses with a high activity of antioxidase, but the top third leaves showed irreversible damage and inactivity of antioxidase. Our results showed that the rapeseed leaves grown under 0R:100B% or CLs with a high BPF ratio showed higher ability to utilize high photonflux, while the leaves grown under 100R:0B% or CLs with a low BPF ratio showed higher efficiency in utilizing low photonflux. Under different R:B photonflux ratios, red and blue lights may play mutual roles in Pn. When the blue light dominated, the Pn showed a B-preference. When the red light dominated, the Pn showed an R-preference. Furthermore, CLs were suitable for the Pn of rapeseed seedlings.
Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization

Thrombin activates endothelial cell signaling by cleaving the protease-activated receptor-1 (PAR1). However, the function of the apparently nonsignaling receptor PAR3 also expressed in endothelial cells is unknown. We demonstrate here the crucial role of PAR3 in potentiating the responsiveness of PAR1 to thrombin. We tested the hypothesis that PAR1/PAR3 heterodimerization and its effect in modifying G protein selectivity was responsible for PAR3 regulation of PAR1 sensitivity. Using bioluminescent resonance energy transfer-2, we showed that PAR1 had comparable dimerization affinity for PAR3 as for itself. We observed increased Gα13 coupling between the PAR1/3 heterodimer compared with the PAR1/1 homodimer. Moreover, knockdown of PAR3 moderated the PAR1-activated increase in endothelial permeability. These results demonstrate a role of PAR3 in allosterically regulating PAR1 signaling governing increased endothelial permeability. Because PAR3 is a critical determinant of PAR1 function, targeting of PAR3 may mitigate the effects of PAR1 in activating endothelial responses such as vascular inflammation.
Intermittent antiretroviral therapy in patients with controlled HIV infection.

BACKGROUND To assess the safety of a drug-sparing treatment regimen in patients with high CD4 cell counts and controlled HIV replication under antiretroviral therapy. METHODS An open-label, non-inferiority study involving 403 adults with CD4 cell counts of 450 x 10(6) cells/l or greater and plasma HIV-1-RNA levels less than 200 copies/ml, randomly assigned to switch to an 8-week off, 8-week on regimen or to continue their antiretroviral regimen. The primary endpoint was the proportion of patients reaching a confirmed CD4 cell count less than 300 x 10(6) cells/l. RESULTS Over 96 weeks, the proportion of patients meeting this endpoint was non-inferior in the intermittent group (3.6 versus 1.5%, upper bound of the 95% confidence interval of the difference 5.6%). No AIDS-defining event and two non-HIV-related deaths (intermittent arm) were recorded. The median decrease from baseline in the CD4 cell count was greater in the intermittent arm (-155 versus -8 x 10(6) cells/l, P < 0.0001). Minor HIV-related events, mainly lymphadenopathy and mucosal candidiasis, were more frequent in the intermittent group (14 versus 7%, P = 0.04) as were thrombocytopenia. The incidence of grade 3-4 non-HIV-related events and laboratory abnormalities were not statistically different between the groups. At week 96, the proportion of patients with plasma HIV-1-RNA levels less than 400 copies/ml were 81 and 90% in the intermittent (8 weeks after treatment resumption) and continuous groups (P = 0.02), respectively, with similar patterns of HIV resistance genotypes. CONCLUSION Despite some limitations, an 8-week off and on intermittent treatment regimen appeared clinically safe over 96 weeks while sparing half of the drug exposure.
Simultaneous measurement of adenosine triphosphate release and aggregation potentiates human platelet aggregation responses for some subjects, including persons with Quebec platelet disorder

Summary Platelet aggregometry and dense granule adenosine triphosphate (ATP) release assays are helpful to diagnose platelet disorders. Some laboratories simultaneously measure aggregation and ATP release using Chronolume®, a commercial reagent containing D-luciferin, firefly luciferase and magnesium. Chronolume® can potentiate sub-maximal aggregation responses, normalising canine platelet disorder findings. We investigated if Chronolume® potentiates human platelet aggregation responses after observing discrepancies suspicious of potentiation. Among patients simultaneously tested by light transmission aggregometry (LTA) on two instruments, 18/43 (42%), including 14/24 (58%) with platelet disorders, showed full secondary aggregation with one or more agonists only in tests with Chronolume®. As subjects with Quebec platelet disorder (QPD) did not show the expected absent secondary aggregation responses to epinephrine in tests with Chronolu-me®, the reason for the discrepancy was investigated using samples from 10 QPD subjects. Like sub-threshold ADP (0.75 μM), Chronolume® significantly increased QPD LTA responses to epinephrine (p<0.0001) and it increased both initial and secondary aggregation responses, leading to dense granule release. This potentiation was not restricted to QPD and it was mimicked adding 1–2 mM magnesium, but not D-luciferin or firefly luciferase, to LTA assays. Chronolume® potentiated the ADP aggregation responses of QPD subjects with a reduced response. Furthermore, it increased whole blood aggregation responses of healthy control samples to multiple agonists, tested at concentrations used for the diagnosis of platelet disorders (p values <0.05). Laboratories should be aware that measuring ATP release with Chronolume® can potentiate LTA and whole blood aggregation responses, which alters findings for some human platelet disorders, including QPD.
The effects of habitat preference, environmental heterogeneity, and inter-individual variation on fitness

ii Preface . iv Table of contents . vi List of tables. xi List of figures . xii Acknowledgments . xiii Dedication . xv Chapter 1: General introduction . 1 1.1 Overview . 1 1.2 Background . 2 1.3 Habitat preference and its effects on individual fitness . 3 1.4 Separating habitat quality and inter-individual variation. 5 1.5 Study system: the song sparrows of Mandarte Island . 6 1.6 Thesis chapters . 8 Chapter 2: Distinguishing individual quality from habitat preference and quality in a territorial passerine . 10 2.
Prognosis and risk factors for idiopathic membranous nephropathy with nephrotic syndrome in Japan.

BACKGROUND Idiopathic membranous nephropathy (IMN) is a representative form of refractory nephrotic syndrome in Japan. Although IMN is thought to run a more benign course in Japanese than in the Caucasian population, risk factors and appropriate treatment are controversial issues. METHODS The research group supported by a grant for "Progressive Renal Disease" from the Ministry of Health, Labor and Welfare, Japan, carried out a national survey of patients with IMN and nephrotic syndrome. Of 1066 nephrotic patients with histopathologically proven IMN registered from 1975 to 1993 in 85 institutions, 949 patients were studied. RESULTS The overall renal survival rates were 95.8%, 90.3%, 81.1%, and 60.5% at 5, 10, 15, and 20 years after diagnosis, respectively. When clinical and histopathologic features at onset of nephrotic syndrome were evaluated by multivariate analysis, male gender, old age (> or =60 years), high serum creatinine concentration (> or =1.5 mg/dL), and the development of tubulointerstitial lesions (> or =20% of the biopsy sample area) were significant predictors of progression to end-stage renal disease (ESRD). The renal survival rate in patients on steroid therapy was significantly higher than in patients on supportive therapy alone. Patients achieving a remission showed a significant reduction of risk for progression. CONCLUSION IMN is a disease with a comparatively good prognosis in Japan even when it is associated with nephrotic syndrome. Steroid therapy, which has not been recommended for IMN in most review articles, seems to be useful at least for Japanese patients. In particular, a remission from heavy proteinuria likely results in a favorable outcome.
Long Live Love. The implementation of a school-based sex-education program in the Netherlands

Implementation of health education programs is often inadequately considered or not considered at all in planning, developing and evaluating interventions. With the focus being predominantly on the adoption stage, little is known about the factors influencing the implementation and continuation stages of the diffusion process. This study contributes to the understanding of factors that promote or impede each stage of the diffusion process in the school setting using the sex education program Long Live Love (LLL) as an example. A survey integrating different diffusion-related concepts was completed by 130 teachers. Results showed that teacher curriculum-related beliefs were associated with all stages in the diffusion process. Although adoption of LLL was predominantly related to teacher curriculum-related beliefs, implementation completeness and fidelity and continued use of LLL were also enhanced by contextual factors, namely teacher training and interactive context variables (school policy, governing body support and student response), respectively. The results of this study can be used to optimize the adoption, implementation and continuation of school-based (sexual) health promotion programs.