Miracle-dz/UniFAR-FTUs huggingface dataset:
Sagging and swelling of the midbrain suggest spontaneous intracranial hypotension rather than a malformation.

Sir, In a recent Brain review article, Barkovich et al. (2009) proposed a new classification for midbrain–hindbrain malformations that takes into account a vast amount of neuroimaging data, as well as results of research in developmental biology and molecular genetics. Based on these findings, the authors also envisage the existence of some malformation that is still not completely understood and for which the pathogenetic mechanism is inferred from biological and genetic studies in animal models. This is the case in a malformation secondary to early anteroposterior transformation at the diencephalic–mesencephalic junction, resulting in shortening and thickening of the midbrain with midline mesencephalic cleft (labelled in the article: Group 1, A.1.c. Gain of diencephalon and loss of midbrain). This malformation is shown in Fig. 4. The magnetic resonance images presented in the figure, however, are identical to those observed in a subgroup of the most severe cases of spontaneous intracranial hypotension, reported in the literature and examined with diffusion studies by our group (Savoiardo et al. , 2007). Spontaneous intracranial hypotension, usually due to …
The relation between anxiety and depressive symptoms in normal subjects and patients with anxiety and/or mood disorders.

OBJECTIVE We investigated the associations between anxiety and depressive symptoms in normal subjects and patients with mood and/or anxiety disorders, using the Japaneses version of Spielberger's STAI and the Zung SDS. METHODS The subjects for the present study were 60 normal subjects, 15 patients with anxiety disorders and, 12 patients with mood disorders meeting the DSM-IV diagnostic criteria. Informed consent was obtained from all subjects. RESULTS 1) Both the mean total state-anxiety (S-anxiety) and trait-anxiety (T-anxiety) scores were significantly higher in patients with anxiety disorders and mood disorders than in normal subjects. 2) The mean total SDS score was significantly higher in patients with anxiety disorders and mood disorders than in normal subjects. 3) In normal subjects, there were significant positive correlations between the total T- and S-anxiety scores and total SDS scores. 4) In patients with anxiety disorders, there were significant positive correlations between the total T- and S-anxiety scores and total SDS scores. 5) In patients with mood disorders, there were nonsignificant positive correlations between the total T- and S-anxiety scores and total SDS scores. CONCLUSION Our results might provide support for the existence of common underlying mechanisms to anxiety and depression.
Nonparametric Second-order Theory of Error Propagation on Motion Groups

Error propagation on the Euclidean motion group arises in a number of areas such as in dead reckoning errors in mobile robot navigation and joint errors that accumulate from the base to the distal end of kinematic chains such as manipulators and biological macromolecules. We address error propagation in rigid-body poses in a coordinate-free way. In this paper we show how errors propagated by convolution on the Euclidean motion group, SE133, can be approximated to second order using the theory of Lie algebras and Lie groups. We then show how errors that are small (but not so small that linearization is valid) can be propagated by a recursive formula derived here. This formula takes into account errors to second order, whereas prior efforts only considered the first-order case. Our formulation is non-parametric in the sense that it will work for probability density functions of any form (not only Gaussians). Numerical tests demonstrate the accuracy of this second-order theory in the context of a manipulator arm and a flexible needle with bevel tip.
Changes in the Material Characteristics of Maize Straw during the Pretreatment Process of Methanation

Pretreatment technology is important to the direct methanation of straw. This study used fresh water, four bacterium agents (stem rot agent, “result” microbe decomposition agent, straw pretreatment composite bacterium agent, and complex microorganism agent), biogas slurry, and two chemical reagents (sodium hydroxide and urea) as pretreatment promoters. Different treatments were performed, and the changes in the straw pH value, temperature, total solid (TS), volatile solid (VS), and carbon-nitrogen ratio (C/N ratio) under different pretreatment conditions were analyzed. The results showed that chemical promoters were more efficient than biological promoters in straw maturity. Pretreatment using sodium hydroxide induced the highest degree of straw maturity. However, its C/N ratio had to be reduced during fermentation. In contrast, the C/N ratio of the urea-pretreated straw was low and was easy to regulate when used as anaerobic digestion material. The biogas slurry pretreatment was followed by pretreatments using four different bacterium agents, among which the effect of the complex microorganism agent (BA4) was more efficient than the others. The current study is significant to the direct and efficient methanation of straw.
Blood product transfusions are associated with an increase in serum (1-3)-beta-d-glucan in infants during the initial hospitalization in neonatal intensive care unit (NICU)

Abstract Introduction: Serum (1-3)-beta-d-glucan (BDG) assay has been proposed as an adjunct for the rapid diagnosis of invasive fungal infection (IFI). However, false-positive results have been reported following transfusion of blood products in adults. Aims: To assess the relationship between blood product transfusion and elevated BDG in neonates. Method: Retrospective study including neonates ≤32 weeks, with no fungal colonization or infection, in whom BDG assay was performed for suspicion of IFI. Patients were classified in Transfusion (n = 78) and No Transfusion (n = 55) groups depending on whether or not they were transfused. Clinical, biochemical and microbiological characteristics were recorded. A BDG assay >80 pg/mL was considered as positive. Statistical analyses: bivariate and multivariate logistic regression. Results (median, IQR): One hundred and thirty-three infants were included (gestational age 28.4 weeks, 26.9–30; birth weight 1000 g, 847–1300). BDG was higher in the Transfusion group (170 pg/mL, 65–317) than in the No Transfusion group (57 pg/mL, 34–108; p < 0.001). False-positive BDG assay results were associated with red blood cells (RBC) and fresh frozen plasma (FFP) transfusions. Conclusion: BDG is increased after RBC and FFP transfusions in neonates, leading to overdiagnosis of IFI. Fungal colonization status in peripheral sites and central cultures could help to reduce the risk of misdiagnosis.
Characterization of the Histoplasma capsulatum-Induced Granuloma1

Rising rates of Histoplasma capsulatum infection are an emerging problem among the rapidly growing population of immune-compromised individuals. Although there is a growing understanding of systemic immunity against Histoplasma, little is known about the local granulomatous response, which is an important component in the control of infection. The focus of this article is the characterization of Histoplasma-induced granulomas. Five days after i.p. infection, infected macrophage appear in the liver and lung; however, no granulomas are apparent. Two days later, well-formed sarcoid granulomas are abundant in the lung and liver of infected mice, which contain all visible Histoplasma. Granulomas are dominated by macrophage and lymphocytes. Most of the Histoplasma and most of the apoptotic cells are found in the center of the lesions. We isolated liver granulomas at multiple time points after infection and analyzed the cellular composition, TCR gene usage, and cytokine production of granuloma-infiltrating cells. The lesions contain both CD4+ and CD8+ T cell subsets, and T cells are the primary source of IFN-γ and IL-17. The main source of local TNF-α is macrophage. Chemokines are produced by both infiltrating macrophage and lymphocytes. Dendritic cells are present in granulomas; however, T cell expansion seems to occur systemically because TCR usage is very heterogeneous even at the level of individual lesions. This study is the first direct examination of host cellular responses in the Histoplasma-induced granuloma representing the specific interface between host and pathogen. Our studies will allow further analysis of key elements of host Histoplasma interactions at the site of chronic infection.
Combination of Anti-VEGF and Laser Photocoagulation for Diabetic Macular Edema: A Review

Diabetic macular edema (DME) is the most common cause of vision loss in diabetic patients. Thirty years ago, the Early Treatment Diabetic Retinopathy Study (ETDRS) demonstrated that focal/grid laser photocoagulation reduces moderate vision loss from DME by 50% or more; thus, macular photocoagulation became the gold standard treatment for DME. However, with the development of anti-VEGF drugs (bevacizumab, ranibizumab, and aflibercept), better outcomes were obtained in terms of visual acuity gain and decrease in macular thickness in some studies when antiangiogenic drugs were administered in monotherapy. Macular laser therapy may still play an important role as an adjuvant treatment because it is able to improve macular thickness outcomes and reduce the number of injections needed. Here, we review some of the clinical trials that have assessed the efficacy of macular laser treatment, either as part of the treatment protocol or as rescue therapy.
The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies

Only a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with the least amount of information about sequence variation of entire mitochondrial DNAs. In this study, a comprehensive overview of all available complete mitochondrial DNA (mtDNA) genomes of the four pan-American haplogroups A2, B2, C1, and D1 is provided by revising the information scattered throughout GenBank and the literature, and adding 14 novel mtDNA sequences. The phylogenies of haplogroups A2, B2, C1, and D1 reveal a large number of sub-haplogroups but suggest that the ancestral Beringian population(s) contributed only six (successful) founder haplotypes to these haplogroups. The derived clades are overall starlike with coalescence times ranging from 18,000 to 21,000 years (with one exception) using the conventional calibration. The average of about 19,000 years somewhat contrasts with the corresponding lower age of about 13,500 years that was recently proposed by employing a different calibration and estimation approach. Our estimate indicates a human entry and spread of the pan-American haplogroups into the Americas right after the peak of the Last Glacial Maximum and comfortably agrees with the undisputed ages of the earliest Paleoindians in South America. In addition, the phylogenetic approach also indicates that the pathogenic status proposed for various mtDNA mutations, which actually define branches of Native American haplogroups, was based on insufficient grounds.
Simulation And Experimental Results Of The Hot Metal Gas Forming Technology For High Strength Steel And Stainless Steel Tubes Forming

Simulation is a key topic within the development of the H_ot M_etal G_as F_orming (HMGF) technology. In this work, tube bulge tests and tubes forming processes using dies were simulated at high temperatures by means of FEM. The tube deformations calculated by the numerical simulations were compared to the results from experiments carried out at different heating conditions and using different input pressure curves. Flow curves for several stainless and high strength steels were experimentally determined in order to be used for the simulation code. Ferritic stainless steel 1.4512 showed very high formability capabilities at high temperatures. During tube bulge tests of the ferritic steel a maximum expansion of tube diameter up to 55% was reached by using a pressure of only 14 bars.
Capitals, ethnic identity and educational qualifications

Cultural capital analysis, or class analysis more generally, exacerbates rather than resolves the anomaly of why non-white ethnic minorities in Britain are over-represented in higher education. Some of these groups have a disproportionate lower, socio-economic profile and yet at least some of these groups are more likely to pursue and achieve entry into higher education than whites, especially, their white working-class peers. They also suffer additional disadvantages such as racism and cultural marginality. Bourdieu's concept of cultural capital is designed to explain why members of a disadvantaged class achieve less educational success than an advantaged class. It is not helpful in explaining why some disadvantaged groups do better than one would have predicted on the basis of a class (and/or racism) analysis. On the other hand, US sociological studies which deploy the concept of social capital in combination with ethnicity to explain the trajectories of ‘second generation’ migrants seem promising. This conclusion is offered on the basis of a brief literature review and a suggestion that the ‘motor’ of the British South Asian and Chinese overcoming of disadvantage lies in migrant parents getting their children to internalize high educational ambitions and to enforce appropriate behaviour.
Exact, Fast and Scalable Parallel DBSCAN for Commodity Platforms

DBSCAN is one of the most popular density-based clustering algorithm capable of identifying arbitrary shaped clusters and noise. It is computationally expensive for large data sets. In this paper, we present a grid-based DBSCAN algorithm, GridDBSCAN, which is significantly faster than the state-of-the-art sequential DBSCAN. The efficiency of GridDBSCAN is achieved by reducing the number of neighborhood queries using spatial locality information, without compromising the quality of clusters. We also propose scalable parallel implementations of GridDBSCAN to leverage a multicore commodity cluster. Clustering results of GridDBSCAN and its parallel implementations are exactly the same as that of classical DBSCAN. The performance of proposed algorithms, both sequential and parallel, is benchmarked against the state-of-the-art algorithms by experimenting on various real datasets. Experimental results show considerable performance improvements achieved by GridDBSCAN and its parallel implementations.
Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines

Purpose We compared fractional anisotropy and radial diffusivity measurements between pediatric canines affected with mucopolysaccharidosis I and pediatric control canines. We hypothesized that lower fractional anisotropy and higher radial diffusivity values, consistent with dysmyelination, would be present in the mucopolysaccharidosis I cohort. Methods Six canine brains, three affected with mucopolysaccharidosis I and three unaffected, were euthanized at 7 weeks and imaged using a 7T small-animal magnetic resonance imaging system. Average fractional anisotropy and radial diffusivity values were calculated for four white-matter regions based on 100 regions of interest per region per specimen. A 95% confidence interval was calculated for each mean value. Results No difference was seen in fractional anisotropy or radial diffusivity values between mucopolysaccharidosis affected and unaffected brains in any region. In particular, the 95% confidence intervals for mucopolysaccharidosis affected and unaffected canines frequently overlapped for both fractional anisotropy and radial diffusivity measurements. In addition, in some brain regions a large range of fractional anisotropy and radial diffusivity values were seen within the same cohort. Conclusion The fractional anisotropy and radial diffusivity values of white matter did not differ between pediatric mucopolysaccharidosis affected canines and pediatric control canines. Possible explanations include: (a) a lack of white matter tissue differences between mucopolysaccharidosis affected and unaffected brains at early disease stages; (b) diffusion tensor imaging does not detect any existing differences; (c) inflammatory processes such as astrogliosis produce changes that offset the decreased fractional anisotropy values and increased radial diffusivity values that are expected in dysmyelination; and (d) our sample size was insufficient to detect differences. Further studies correlating diffusion tensor imaging findings to histology are warranted.
Improving Germination in Windmillgrass Ecotypes

Abstract Hooded windmillgrass (Chloris cucullata Bisch.) and shortspike windmillgrass (C. subdolichostachya Muell.) are native perennial grasses with potential for planting on highly erodible sites and on sites where introduced species are not desired. However, in both species, seeds are dormant resulting in poor germination. The objectives of this study were to evaluate effects of lemma and palea removal and caryopsis scarification on seed germination of 8 outstanding ecotypes selected in previous studies for survival and growth characteristics. Seed treatments were 1) whole seed, 2) naked caryopsis, 3) scarified naked caryopsis (30 s), 4) scarified naked caryopsis (50 s), and 5) scarified naked caryopsis (60 s). Germination conditions were 12 h dark 20°C and 12 h light 30°C. Seed lot viability varied from 55% to 62% for shortspike windmillgrass ecotypes and from 71% to 78% for hooded windmillgrass ecotypes. Initial germination index (MIR10) of naked caryopsis for shortspike windmillgrass ecotypes ranged from 16.3 to 21.6, compared to range from 0.2 to 0.6 to whole seed; whereas hooded windmillgrass ecotypes MIR10 ranged from 30.6 to 33.0 to naked caryopsis, compared to range from 5.8 to 8.0 to whole seed. The greatest total germination (P < 0.05) was obtained with naked caryopsis for all ecotypes and the scarification treatments did not have a positive effect on this parameter. As scarification time increased the total germination decreased. Lemma and palea removal improved (P < 0.05) total germination for all studied ecotypes.
Functional specificity of the nematode Hox gene mab-5

Hox genes encode evolutionarily conserved transcription factors involved in morphological specification along the anteroposterior body axis of animals. The two most striking features of Hox genes are colinearity and the strong sequence conservation. Among all animals studied so far, the nematode Caenorhabditis elegans contains one of the most divergent Hox clusters. The core cluster contains only four members, which in part deviate from the colinearity rule. In addition, orthologous and paralogous nematode Hox sequences diverged substantially. Given these nematode-specific features, we asked how these Hox proteins evolved and how they provide functional specificity. We investigated the role of MAB-5 during ray formation and established an in vivo assay using Cel-mab-5 regulatory elements to express orthologous, paralogous and chimeric cDNAs in a Cel-mab-5 mutant background. We show that the MAB-5 ortholog from Pristionchus pacificus, but not the C. elegans paralogous Hox proteins can rescue Cel-mab-5. Experiments with chimeric, truncated and mutagenized Hox proteins suggest the specificity to be conferred by the N-terminal arm and helix I, but not helix II of the homeodomain.
Potential-induced degradation in photovoltaic modules: a critical review

Potential-induced degradation (PID) has received considerable attention in recent years due to its detrimental impact on photovoltaic (PV) module performance under field conditions. Both crystalline silicon (c-Si) and thin-film PV modules are susceptible to PID. While extensive studies have already been conducted in this area, the understanding of the PID phenomena is still incomplete and it remains a major problem in the PV industry. Herein, a critical review of the available literature is given to serve as a one-stop source for understanding the current status of PID research. This paper also aims to provide an overview of future research paths to address PID-related issues. This paper consists of three parts. In the first part, the modelling of leakage current paths in the module package is discussed. The PID mechanisms in both c-Si and thin-film PV modules are also comprehensively reviewed. The second part summarizes various test methods to evaluate PV modules for PID. The last part focuses on studies related to PID in the omnipresent p-type c-Si PV modules. The dependence of temperature, humidity and voltage on the progression of PID is examined. Preventive measures against PID at the cell, module and system levels are illustrated. Moreover, PID recovery in standard p-type c-Si PV modules is also studied. Most of the findings from p-type c-Si PV modules are also applicable to other PV module technologies.
Sentiment analysis on conversational texts

This paper describes ongoing work related to the analysis of spoken utterance transcripts and estimating the speaker’s attitude towards the whole dialogue on the basis of their opinions expressed by utterances. Using the standard technology used in sentiment analysis, we report promising results which can be linked to the conversational participants’ self-evaluation of their experience of the interaction.
Regulation of competence development in Haemophilus influenzae.

Development of competence for DNA uptake by the bacterium Haemophilus influenzae is tightly regulated, and expression of the cell's complement of competence genes is absolutely dependent on the cAMP-CRP complex. A second regulator of competence may maximize competence under starvation conditions. Several investigators have recently identified a consensus sequence (competence regulatory element, CRE) in the promoter regions of some competence genes and have proposed that this may be a binding site for Sxy (TfoX), a putative positive regulator of competence. However, a scoring method that reliably ranks candidate binding sites according to affinity for the cognate binding protein predicts that the cAMP-CRP complex will bind CRE sequences with high affinity. Moreover, the predicted Sxy protein lacks recognizable DNA-binding motifs and has not been shown to bind DNA. No other consensus sequences (putative binding sites) were identified in the promoter regions of competence genes. These observations suggest that the proposed competence-specific regulatory elements are in fact CRP-binding sites, and highlight the central role of cAMP-an established bacterial mediator of the response to nutritional stress-in competence regulation. Minor sequence elements uniquely conserved in the set of CRE sequences are predicted to reduce CRP affinity, and a model is suggested in which a secondary regulator of competence genes may interact with CRP under certain conditions to stabilize the initiation complex.
Surgical Techniques of Laparoscopic Inguinal Hernia Repair in Childhood: A Critical Appraisal

Laparoscopic inguinal hernia repair started over two decades ago. It has been gaining ground as a mode of treatment for inguinal hernia in children. Several surgical techniques have emerged since its inception. The aim of this article is to review the role of laparoscopy in inguinal hernia repair in children, the various emerging laparoscopic surgical techniques, and their current trend in pediatric surgical practice. In this study, extensive review and analysis of recent articles on laparoscopic inguinal hernia repair in children revealed that laparoscopy plays a great role in the treatment of inguinal hernia in children. There were several emerging laparoscopic techniques, with trends toward extracorporeal suturing and knotting technique and single-port access technique as well. The recent advance is toward the use of tissue adhesives in laparoscopic inguinal hernia repair in children.