Miracle-dz/UniFAR-FTUs huggingface dataset:
Time-space tradeoff lower bounds for integer multiplication and graphs of arithmetic functions

We prove exponential size lower bounds for nondeterministic and randomized read-k BPs as well as a time-space tradeoff lower bound for unrestricted, deterministic multi-way BPs computing the middle bit of integer multiplication. The lower bound for randomized read-k BPs is superpolynomial as long as the error probability is superpolynomially small. For polynomially small error, we have a polynomial upper bound on the size of approximating read once BPs for this function. The lower bounds follow from a more general result for the graphs of universal hash classes that is applicable to the graphs of arithmetic functions such as integer multiplication, convolution, and finite field multiplication.
Achievable Communication Rates in Ad hoc Wireless Networks Using Local Node Cooperation

We consider two strategies for communication in ad hoc networks with local node cooperation. Groups of adjacent nodes transmit and relay information simultaneously in order to increase the throughput. For the proposed schemes we derive achievability bounds on the communication rates and demonstrate sizable gains over the corresponding time division multiple access based strategies. The obtained bounds closely follow recently derived information theoretic upper bounds on communication rates. Additionally we address the impact of traffic localization on the achievable rates and the receiver complexity.
Contribution of Spectral Shapes to Tone Perception

Tones in tonal languages are defined based on the characteristics of their fundamental frequencies. However, it has been shown that fundamental frequencies alone do not lead to good tone identification, either by human or machines. This paper reports a study based on tone perception experiments in which participants identified Thai tones from recorded mono-syllabic, bi-syllabic, and trisyllabic stimuli as well as their modified counterparts. Stimuli were modified in various aspects so that effects of fundamental frequency, syllable energy envelope, and spectral shape to tone perception could be studied. Results indicate that spectral shape, especially in the vicinity of the first formant, contributes significantly to the participants’ ability to correctly identify tones and the contribution is greater with more syllables in the stimuli.
Relationships between Serum Luteinizing Hormone Level, Endometrial Thickness and Body Mass Index in Polycystic Ovary Syndrome Patients with and without Endometrial Hyperplasia

Background The endometrial hyperplasia measured by ultrasound in polycystic ovary syndrome (PCOS) women is strongly related to pathologic endometrial thickness, but there is no consensus on the relation between serum luteinizing hormone (LH) and either of these factors: pathologic endometrial hyperplasia and body mass index (BMI). Materials and Methods In this observational cross-sectional study, three hundred fifty infertile PCOS women were involved in this research. An endometrial biopsy was taken by using a pipelle instrument, regardless of menstrual cycle’s day and all samples were reported by the same pathologist. Basal serum LH level was compared between two subgroups (hyperplasia and non-hyperplasia). The intended population was divided into three groups according to BMI and basal serum LH, later on the comparison was made in three groups. Chi-square test was applied to compare nominal variables between groups. Mann-Whitney U, and one way ANOVA tests were used to compare means on the basis of the result of normality test. Results The frequency of endometrial hyperplasia was 2.6%. Endometrial thickness in the patients with endometrial hyperplasia was significantly higher than that of a normal endometrium (10.78 ± 3.70 vs. 7.90 ± 2.86 respectively, P=0.020). There was no relation between endometrial hyperplasia and serum LH (P=0.600). The ANOVA test showed serum LH levels were not the same among three BMI groups (P=0.007). Post hoc test was also performed. It showed that the LH level in normal BMI group was significantly higher than those of other groups (P=0.005 and P=0.004), but there was no statistical difference between overweight and obese groups (P=0.8). We found no relationship between BMI and endometrial thickness in PCOS patients (P=0.6). Conclusion Sonographic endometrial stripe thickness is predictive for endometrial hyperplasia in PCOS women. We could not find out any relationship between serum LH level and BMI with endometrial thickness in PCOS patients. However, our study confirmed a diverse relationship between serum LH level and BMI in PCOS patients.
Clustered Multi-Task Learning: A Convex Formulation

In multi-task learning several related tasks are considered simultaneously, with the hope that by an appropriate sharing of information across tasks, each task may benefit from the others. In the context of learning linear functions for supervised classification or regression, this can be achieved by including a priori information about the weight vectors associated with the tasks, and how they are expected to be related to each other. In this paper, we assume that tasks are clustered into groups, which are unknown beforehand, and that tasks within a group have similar weight vectors. We design a new spectral norm that encodes this a priori assumption, without the prior knowledge of the partition of tasks into groups, resulting in a new convex optimization formulation for multi-task learning. We show in simulations on synthetic examples and on the IEDB MHC-I binding dataset, that our approach outperforms well-known convex methods for multi-task learning, as well as related non-convex methods dedicated to the same problem.
Optimization of the Changing Phase Fluid in a Carnot Type Engine for the Recovery of a Given Waste Heat Source

A Carnot type engine with a changing phase during the heating and the cooling is modeled with its thermal contact with the heat source. In a first optimization, the optimal high temperature of the cycle is determined to maximize the power output. The temperature and the mass flow rate of the heat source are given. This does not take into account the converter internal fluid and its mass flow rate. It is an exogenous optimization of the converter. In a second optimization, the endogenous optimization, the isothermal heating corresponds only to the vaporization of the selected fluid. The maximization of the power output gives the optimal vaporization temperature of the cycled fluid. Using these two optima allows connecting the temperature of the heat source to the working fluid used. For a given temperature level, mass flow rate and composition of the waste heat to recover, an optimal fluid and its temperature of vaporization are deduced. The optimal conditions size also the internal mass flow rate and the compression ratio (pump size). The optimum corresponds to the maximum of the power output and must be combined with the environmental fluid impact and the technological constraints.
Spontaneous primary intraventricular hemorrhage in adults: clinical data, etiology and outcome.

AIM Primary intraventricular hemorrhage (PIVH), bleeding in the ventricular system without a recognizable parenchymal component, is a rare neurological disorder. The purpose of this study was to identify clinical features, risk factors, etiology and outcome of patients with PIVH. MATERIAL AND METHODS We retrospectively reviewed the clinical data, complementary examinations, outcome and computed tomography (CT) IVH score of 24 patients in our hospital from 2004 to 2008. We identified 24 patients with the inclusion criteria of non-traumatic PIVH. Their mean age was 60.6+/-17.4 years (range 38-79). Fourteen patients were male and 10 were female. RESULTS The major symptoms included headache (n=24), loss of consciousness (n=6), confusion and disorientation (n=14), nausea/vomiting (n=10). Angiography revealed vascular malformations in five patients (21%). Other possible causative factors were hypertension in 12 patients (50%) and clotting disorder in one. The aetiology remained unknown in six patients. Most PIVH patients had associated hydrocephalus (58%) and 37% of the patients required ventricular drainage. In-hospital mortality was high (41%) and a FOUR score <or=10, GCS <or=8 and early hydrocephalus were independent predictors of mortality. CONCLUSION Hypertension is the most common associated risk factor for PIVH followed by vascular malformation. Spontaneous resorption and rebleeding may be seen. The neurological status of the patients and an early developing hydrocephalus are the most important risk factors.
Treatment of tuberculosis and optimal dosing schedules

Intermittent tuberculosis treatment regimens have been developed to facilitate treatment supervision. Their efficacy has been substantiated by clinical trials and tuberculosis control programmes, notwithstanding the lack of head-to-head comparison between daily and intermittent regimens. Recently, there has been opposing evidence from observational studies, pharmacokinetic-pharmacodynamic studies and animal models that intermittent treatment increases the risk of relapse, treatment failure or acquired rifamycin resistance, especially among HIV-infected patients. Systematic reviews have been conflicting. PubMed, Ovid MEDLINE and EMBASE were systematically searched for publications in English to evaluate the evidence about dosing schedules and treatment efficacy. Levels of evidence and grades of recommendation were assigned largely according to clinical evidence with reference to the Scottish Intercollegiate Guidelines Network guideline development handbook. A total of 32 articles were included after excluding 331 ineligible articles, 42 non-analytical studies, 22 narrative reviews or expert opinions and 44 articles embedded in systematic reviews. These included 9 systematic reviews, 8 controlled studies, 9 pharmacokinetic-pharmacodynamic studies, 5 mouse studies and 1 article about guinea pig experiments. Findings suggest high levels of evidence for using daily dosing schedules, especially during the initial phase in the presence of cavitation, isoniazid resistance and advanced HIV co-infection, to reduce the risk of treatment failure, recurrence and acquired drug resistance including acquired rifamycin resistance. This review justifies the use of daily schedules in standard tuberculosis treatment regimens (particularly in the initial phase), corroborates prevailing understanding of pharmacokinetics-pharmacodynamics and mycobacterial persisters, and supports exploration of rifapentine-containing regimens in higher dosages and frequency.
Generation of analytical fragility curves for Ghanaian non-ductile reinforced concrete frame buildings

This study is on seismic safety evaluation of non-ductile reinforced concrete (RC) frame buildings in Ghana. Generic 3-, 4- and 6-storey non-ductile RC buildings were characterised for assessment. The generic buildings were designed according to British Standard (BS) 8110. The fragility curve parameters were generated using inelastic time history analyses for seismic demand and inelastic pushover analyses for structural capacity of the buildings. As a result of lack of real time histories in Ghana, 3 suites of 100 synthetic time history records each were generated in order to generate lower and upper bounds for inelastic dynamic response. Parameters of collapse fragility curves with 50% probability of exceedance were established for the generic non-ductile Ghanaian frame buildings using short duration near-fault like records. All the curves represent the probability of exceeding the collapse limit state as a function of the peak ground acceleration (PGA) and spectral acceleration at the fundamental mode period of the generic buildings. Using the data from the nonlinear dynamic analysis of the generic buildings under all 300 synthetic time histories, a pair of three sets of fragility curves was developed. Results obtained showed that the generic non-ductile 3 to 6 storey RC frame buildings subjected to near-fault like ground motions may record high probabilities of collapse, if they are situated in 0.25 to 0.35 g PGA seismic zones.
Reducing Intimate and Paying Partner Violence Against Women Who Exchange Sex in Mongolia

Women who exchange sex for money or other goods, that is, female sex workers, are at increased risk of experiencing physical and sexual violence from both paying and intimate partners. Exposure to violence can be exacerbated by alcohol use and HIV/STI risk. The purpose of this study is to examine the efficacy of a HIV/STI risk reduction and enhanced HIV/STI risk reduction intervention at decreasing paying and intimate partner violence against Mongolian women who exchange sex and engage in harmful alcohol use. Women are recruited and randomized to either (a) four sessions of a relationship-based HIV/STI risk reduction intervention (n = 49), (b) the same HIV/STI risk reduction intervention plus two additional motivational interviewing sessions (n = 58), or (c) a four session control condition focused on wellness promotion (n = 59). All the respondents complete assessments at baseline (preintervention) as well as at immediate posttest, 3 and 6 months postintervention. A multilevel logistic model finds that women who participated in the HIV/STI risk reduction group (OR = 0.14, p < .00), HIV/STI risk reduction and motivational interview group (OR = 0.46, p = .02), and wellness (OR = 0.20, p < .00) group reduced their exposure to physical and sexual violence in the past 90 days. No significant differences in effects are observed between conditions. This study demonstrates the efficacy of a relationship-based HIV/STI risk reduction intervention, a relationship-based HIV/STI risk reduction intervention combined with motivational interviewing, and a wellness promotion intervention in reducing intimate and paying partner violence against women who exchange sex in Mongolia. The findings have significant implications for the impact of minimal intervention and the potential role of peer networks and social support in reducing women’s experiences of violence in resource poor settings.
Iron Supplementation in Suckling Piglets: How to Correct Iron Deficiency Anemia without Affecting Plasma Hepcidin Levels

The aim of the study was to establish an optimized protocol of iron dextran administration to pig neonates, which better meets the iron demand for erythropoiesis. Here, we monitored development of red blood cell indices, plasma iron parameters during a 28-day period after birth (till the weaning), following intramuscular administration of different concentrations of iron dextran to suckling piglets. To better assess the iron status we developed a novel mass spectrometry assay to quantify pig plasma levels of the iron-regulatory peptide hormone hepcidin-25. This hormone is predominantly secreted by the liver and acts as a negative regulator of iron absorption and reutilization. The routinely used protocol with high amount of iron resulted in the recovery of piglets from iron deficiency but also in strongly elevated plasma hepcidin-25 levels. A similar protocol with reduced amounts of iron improved hematological status of piglets to the same level while plasma hepcidin-25 levels remained low. These data show that plasma hepcidin-25 levels can guide optimal dosing of iron treatment and pave the way for mixed supplementation of piglets starting with intramuscular injection of iron dextran followed by dietary supplementation, which could be efficient under condition of very low plasma hepcidin-25 level.
Growth response of conifer trees from high-altitude region of western himalaya

Tree-ring width index chronologies of some species (Abies pindrow and Picea smithiana) of Western Hima-laya are sensitive to the moisture availability and amount of soil moisture of the region. The first prin-cipal component among the site chronologies explain-ing 61.2 of the common variance is strongly correlated with Palmer Drought Severity Index dur-ing summer season (May-July). Whereas increased temperature of the region had significant adverse effect on tree growth. The moisture availability, espe-cially in the growing season is found more conducive in developing the annual tree-ring width compared to rainfall during the season. Moreover, the increasing temperature and vapour pressure during November and December of the previous year might play an important role for early snow melt over region, which maintains enough soil moisture favouring trees growth during subsequent growing season of the trees as well as in physiological processes.
The Three-Dimensional Structure of the Flagellar Rotor from a Clockwise-Locked Mutant of Salmonella enterica Serovar Typhimurium

ABSTRACT Three-dimensional reconstructions from electron cryomicrographs of the rotor of the flagellar motor reveal that the symmetry of individual M rings varies from 24-fold to 26-fold while that of the C rings, containing the two motor/switch proteins FliM and FliN, varies from 32-fold to 36-fold, with no apparent correlation between the symmetries of the two rings. Results from other studies provided evidence that, in addition to the transmembrane protein FliF, at least some part of the third motor/switch protein, FliG, contributes to a thickening on the face of the M ring, but there was no evidence as to whether or not any portion of FliG also contributes to the C ring. Of the four morphological features in the cross section of the C ring, the feature closest to the M ring is not present with the rotational symmetry of the rest of the C ring, but instead it has the symmetry of the M ring. We suggest that this inner feature arises from a domain of FliG. We present a hypothetical docking in which the C-terminal motor domain of FliG lies in the C ring, where it can interact intimately with FliM.
Homeostatic T cell proliferation in a T cell-dendritic cell coculture system

Naïve T cells do not proliferate in normal individuals in the absence of antigen stimulation, but they proliferate spontaneously when T cells are severely depleted. We show here that coculture of syngeneic dendritic cells (DC) with naïve T cells expressing a single T cell receptor also results in T cell proliferation in the absence of foreign antigen. As in lymphopenic mice, where T cell proliferation depends upon DC, this response in the coculture system requires interaction of the T cells' T cell receptor with self-peptide–MHCs on DC. This in vitro proliferation also requires soluble factors, including IL-15 secreted by DC, and can be inhibited potently by cell–cell contact with CD4+CD25+ regulatory T cells. The coculture system described may illuminate mechanisms that maintain stable numbers of T cells in normal individuals.
Bounds on the number of hidden neurons in multilayer perceptrons

Fundamental issues concerning the capability of multilayer perceptrons with one hidden layer are investigated. The studies are focused on realizations of functions which map from a finite subset of E(n) into E(d). Real-valued and binary-valued functions are considered. In particular, a least upper bound is derived for the number of hidden neurons needed to realize an arbitrary function which maps from a finite subset of E(n ) into E(d). A nontrivial lower bound is also obtained for realizations of injective functions. This result can be applied in studies of pattern recognition and database retrieval. An upper bound is given for realizing binary-valued functions that are related to pattern-classification problems.
Pulmonary capillary wedge pressure during exercise and long-term mortality in patients with suspected heart failure with preserved ejection fraction.

AIMS In patients with suspected heart failure with preserved ejection fraction (HFpEF), invasive exercise testing may be considered when measurements at rest are inconclusive. However, the prognostic impact of invasive exercise testing is uncertain, so far. METHODS AND RESULTS We retrospectively analysed mortality in 355 patients [mean age 61.2 ± 11.3 years, 235 (66.2%) women] with unexplained dyspnoea and suspected HFpEF. During an invasive haemodynamic stress test pulmonary capillary wedge pressure (PCWP) at rest and the PCWP response to exercise, expressed as the ratio of PCWP at peak exercise to workload normalized to body weight [PCWL (mmHg/W/kg)], were recorded. Both PCWP at rest and PCWL were significant and independent predictors of long-term mortality. Adding PCWL to PCWP at rest improved reclassification of patients into survivors or non-survivors with a net reclassification improvement (NRI) of 0.56 (95% CI: 0.29-0.83; P < 0.001). Ten-year mortality was 6.6% in subjects with low PCWP at rest (≤ 12 mmHg) and low PCWL (≤ 25.5 mmHg/W/kg); 28.2% in patients with low PCWP and high PCWL and 35.2% in those with high PCWP and high PCWL. Compared with patients with low PCWP and low PCWL, the adjusted hazard ratio for mortality was 2.37 (95% CI: 1.09-5.17; P = 0.029) for the low-PCWP/high-PCWL group and 4.75 (95% CI: 1.90-11.84; P < 0.001) for patients with high PCWP/high PCWL. CONCLUSION In patients with suspected HFpEF, invasive exercise testing substantially improves prediction of long-term mortality. An excessive rise of PCWP during exercise despite normal PCWP at rest is associated with increased mortality and may be considered as early HFpEF.
Predictors of Early Cardiac Morbidity and Mortality After Ischemic Stroke

Background and Purpose— In the first 3 months after acute ischemic stroke, 2% to 6% of patients die from cardiac causes. This may reflect preexisting cardiac disease, cardiac dysfunction related to the acute neurohumoral and autonomic stress response to stroke, or both. Delineation of a high-risk group could facilitate prevention strategies. We aimed to describe the temporal profile of cardiac risk after stroke and develop a predictive model of serious cardiac adverse events (SCAEs) using baseline variables. Methods— We used data from the one trial in the Virtual International Stroke Trials Archive that matched prespecified criteria. Survival analysis was used to describe the temporal profile of cardiac events after stroke. Prognostic determinants were assessed with multivariable logistic regression, and a risk score was derived from the key predictor variables. Results— Of 846 ischemic stroke patients, 35 (4.1%) died from cardiac causes and 161 (19.0%) suffered at least one SCAE. The hazard of cardiac death was highest (0.001/d) in the second week. Hazard of a first SCAE peaked at 0.02/d between day 2 and 3. The 5 factors most predictive of SCAEs were a history of heart failure (OR 3.33 [2.28, 4.89], P<0.001), diabetes (OR 2.11 [1.39, 3.21], P<0.001), baseline creatinine >115&mgr;mol/L (OR 1.77 [1.16, 2.70], P=0.008), severe stroke (OR 1.98 [1.34,2.91], P=0.001), and a long QTc or ventricular extrasystoles on ECG (OR 1.93 [1.31, 2.85], P=0.001). Risk of SCAEs ranged from 6.3% (no predictors) to 62.2% (≥4 predictors). Conclusion— Serious cardiac events are common in the acute period after stroke. Patients at highest risk are identifiable and may benefit from more aggressive strategies to improve survival.