Miracle-dz/UniFAR-FTUs huggingface dataset:
Validity and variability of xBRS: instantaneous cardiac baroreflex sensitivity

Spontaneous oscillations of blood pressure (BP) and interbeat interval (IBI) may reveal important information on the underlying baroreflex control and regulation of BP. We evaluated the method of continuously measured instantaneous baroreflex sensitivity by cross correlation (xBRS) validating its mean value against the gold standard of phenylephrine (Phe) and nitroprusside (SNP) bolus injections, and focusing on its spontaneous changes quantified as variability around the mean. For this purpose, we analyzed data from an earlier study of eight healthy males (aged 25–46 years) who had received Phe and SNP in conditions of baseline and autonomic blocking agents: atropine, propranolol, and clonidine. Average xBRS corresponds well to Phe/SNP‐BRS, with xBRS levels ranging from 1.2 (atropine) to 102 msec/mmHg (subject asleep under clonidine). Time shifts from BP‐ to IBI‐signal increased from ≤1 sec (maximum correlations within the current heartbeat) to 3–5 sec (under atropine). Plotted on a logarithmic vertical scale, xBRS values show 40% variability (defined as SD/mean) over the whole range in the various conditions, except twice when the subjects had fallen asleep and it dropped to 20%. The xBRS oscillates at frequencies of 0.1 Hz and lower, dominant between 0.02–0.05 Hz. Although xBRS is the result of IBI/BP‐changes, no linear coherence was found in the cross‐spectra of the xBRS‐signal and IBI or BP. We speculate that the level of variability in the xBRS‐signal may act as a probe into the central nervous condition, as evidenced in the two subjects who fell asleep with high xBRS and only 20% of relative variation.
Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China

Esophageal cancer incidence and mortality rates in Linxian, China are among the highest in the world. We examined risk factors for esophageal squamous cell carcinoma (ESCC), gastric cardia cancer (GCC), and gastric noncardia cancer (GNCC) in a population‐based, prospective study of 29,584 adults who participated in the Linxian General Population Trial. All study participants completed a baseline questionnaire that included questions on demographic characteristics, personal and family history of disease, and lifestyle factors. After 15 years of follow‐up, a total of 3,410 incident upper gastrointestinal cancers were identified, including 1,958 ESCC, 1,089 GCC and 363 GNCC. Cox proportional hazard models were used to estimate risks. Increased age and a positive family history of esophageal cancer (including ESCC or GCC) were significantly associated with risk at all 3 cancer sites. Additional risk factors for ESCC included being born in Linxian, increased height, cigarette smoking and pipe smoking; for GCC, male gender, consumption of moldy breads and pipe smoking; and for GNCC, male gender and cigarette smoking. Protective factors for ESCC included formal education, water piped into the home, increased consumption of meat, eggs and fresh fruits and increased BMI; for GCC, formal education, water piped into the home, increased consumption of eggs and fresh fruits and alcohol consumption; and for GNCC, increased weight and BMI. General socioeconomic status (SES) is a common denominator in many of these factors and improving SES is a promising approach for reducing the tremendous burden of upper gastrointestinal cancers in Linxian.
Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation

Background: AA amyloidosis develops in patients with chronic inflammatory diseases. The AA amyloid proteins are proteolytic fragments obtained from serum amyloid A (SAA). Previous studies have provided evidence that endosomes or lysosomes might be involved in the processing of SAA, and contribute to the pathology of AA amyloidosis. Objective: To investigate the anatomical distribution of cathepsin (Cath) B and CathL in AA amyloidosis and their ability to process SAA and AA amyloid proteins. Methods and results: CathB and CathL were found immunohistochemically in every patient with AA amyloidosis and displayed a spatial relationship with amyloid in all the cases studied. Both degraded SAA and AA amyloid proteins in vitro. With the help of mass spectrometry 27 fragments were identified after incubation of SAA with CathB, nine of which resembled AA amyloid proteins, and seven fragments after incubation with CathL. CathL did not generate AA amyloid-like peptides. When native human AA amyloid proteins were used as a substrate 26 fragments were identified after incubation with CathB and 18 after incubation with CathL. Conclusion: The two most abundant and ubiquitously expressed lysosomal proteases can cleave SAA and AA amyloid proteins. CathB generates nine AA amyloid-like proteins by its carboxypeptidase activity, whereas CathL may prevent the formation of AA amyloid proteins by endoproteolytic activity within the N-terminal region of SAA. This is particularly interesting, because AA amyloidosis is a systemic disease affecting many organs and tissue types, almost all of which express CathB and CathL.
Understanding intermediate layers using linear classifier probes

Neural network models have a reputation for being black boxes. We propose to monitor the features at every layer of a model and measure how suitable they are for classification. We use linear classifiers, which we refer to as "probes", trained entirely independently of the model itself. This helps us better understand the roles and dynamics of the intermediate layers. We demonstrate how this can be used to develop a better intuition about models and to diagnose potential problems. We apply this technique to the popular models Inception v3 and Resnet-50. Among other things, we observe experimentally that the linear separability of features increase monotonically along the depth of the model.
Someone’s Going to Hear about This

The purpose of this study was to examine how the nature of dissenttriggering events influenced to whom employees chose to express dissent. This was accomplished by asking respondents to report the frequency with which they expressed upward dissent to managers and supervisors, lateral dissent to coworkers, and displaced dissent to people external to their organizations (i.e., family and nonwork friends) in response to different dissent-triggering events. Structural equation models were employed. Results revealed that employeeswere more likely to express dissent to supervisors and coworkers about issues related to their coworkers and about organizational functions such as decision making and organizational change than they were to express dissent about ethical practices and preventing harm to employees. Employees did not appear to differentiate the amount of dissent they expressed to people outside of their organizations as a function of dissent-triggering events.
Executive function in treatment-resistant depression before and after electroconvulsive therapy

Abstract Objectives: The aim of this study was to examine executive functions (EF) in patients with treatment-resistant depression (TRD) before and after bitemporal electroconvulsive therapy (ECT) and to evaluate possible associations between the depression severity and executive tasks performances. Methods: Patients (n = 29), treated with bitemporal ECT, underwent assessment at three time points: baseline, immediately after ECT course and 1 month later. The Stockings of Cambridge (SOC, CANTAB) was used to assess EF: (1) number of problems solved in minimum moves (SOC-P), (2) initial thinking time (SOC-I) and (3) subsequent thinking time (SOC-T). Results: The scores on the Hamilton Depression Rating Scale and the Clinical Global Impression scale were significantly reduced over time, with no negative effects on the EF. Among SOC subtests, only SOC-I improved over time, which was significantly correlated with the depressive symptoms reduction. SOC-T and SOC-P remained unchanged and did not correlate with mood. Interestingly, the patients with more lifetime psychiatric hospitalisations and more ECT applications were more likely to drop-out and to have longer SOC-T while performing the test. Conclusions: Our results support the view that ECT does not produce long-lasting EF deficits, nor exacerbates the pre-existing ones. The improvement of the EF performances during and after the ECT-induced alleviation of mood symptoms in TRD is based mostly on the reduction of time needed to plan the problem solution.
Spontaneous counterfactual thoughts and causal explanations

We report two Experiments to compare counterfactual thoughts about how an outcome could have been different and causal explanations about why the outcome occurred. Experiment 1 showed that people generate counterfactual thoughts more often about controllable than uncontrollable events, whereas they generate causal explanations more often about unexpected than expected events. Counterfactual thoughts focus on specific factors, whereas causal explanations focus on both general and specific factors. Experiment 2 showed that in their spontaneous counterfactual thoughts, people focus on normal events just as often as exceptional events, unlike in directed counterfactual thoughts. The findings are consistent with the suggestion that counterfactual thoughts tend to focus on how a specific unwanted outcome could have been prevented, whereas causal explanations tend to provide more general causal information that enables future understanding, prediction, and intervention in a wide range of situations.
Simplified user scheduling and mode selection algorithm for multiuser MIMO systems with limited-feedback CSIT linear precoding

In this paper we propose a simplified user scheduling algorithm for the downlink of multiuser multiple antenna systems with limited feedback channel state information available at the transmitter (CSIT) and block diagonalization (BD) precoding. In similar work, the perfect CSIT for all users is generally assumed, but it is normally not available. Optimal user scheduling involves exhaustive search, which becomes very complex for realistic numbers of users and transmit antennas. We employ existing vector quantization algorithms to obtain quantized feedback of CSIT. A simplified heuristic user scheduling metric is proposed, which is shown to achieve performance close to that of the exhaustive search method. Further simplification of the greedy scheduling algorithm is obtained with an intermediate user grouping technique. A user-side single antenna/mode selection technique in conjunction with the proposed user scheduling algorithm is also proposed. The proposed algorithm is of low complexity, but provides performance close to a highly complex exhaustive search.
For Polanyian Economic Geographies

Karl Polanyi has been an influential but also somewhat elusive figure in economic geography. Best known for his evocative notion of social embeddedness, it is perhaps fitting that Polanyi's presence has been more metaphorical than substantive. The paper asks what a more engaged Polanyian economic geography might look like. Focusing on methodological affinities, a response is developed in terms of a commitment to the substantivist (as opposed to formal) analysis of actually existing economic formations, together with a more purposive embrace of institutionalism, holism, and comparativism.
CMOS Voltage and Current Reference Circuits consisting of Subthreshold MOSFETs – Micropower Circuit Components for Power-Aware LSI Applications –

The development of ultra-low power LSIs is a promising area of research in microelectronics. Such LSIs would be suitable for use in power-aware LSI applications such as portable mobile devices, implantable medical devices, and smart sensor networks [1]. These devices have to operate with ultra-low power, i.e., a few microwatts or less, because they will probably be placed under conditions where they have to get the necessary energy from poor energy sources such as microbatteries or energy scavenging devices [2]. As a step toward such LSIs, we first need to develop voltage and current reference circuits that can operate with an ultra-low current, several tens of nanoamperes or less, i.e., sub-microwatt operation. To achieve such low-power operation, the circuits have to be operated in the subthreshold region, i.e., a region at which the gate-source voltage of MOSFETs is lower than the threshold voltage [3; 4]. Voltage and current reference circuits are important building blocks for analog, digital, and mixed-signal circuit systems in microelectronics, because the performance of these circuits is determined mainly by their bias voltages and currents. The circuits generate a constant reference voltage and current for various other components such as operational amplifiers, comparators, AD/DA converters, oscillators, and PLLs. For this purpose, bandgap reference circuits with CMOS-based vertical bipolar transistors are conventionally used in CMOS LSIs [5; 6]. However, they need resistors with a high resistance of several hundred megaohms to achieve low-current, subthreshold operation. Such a high resistance needs a large area to be implemented, and this makes conventional bandgap references unsuitable for use in ultra-low power LSIs. Therefore, modified voltage and current reference circuits for lowpower LSIs have been reported (see [7]-[12], [14]-[17]). However, these circuits have various problems. For example, their power dissipations are still large, their output voltages and currents are sensitive to supply voltage and temperature variations, and they have complex circuits with many MOSFETs; these problems are inconvenient for practical use in ultra-low power LSIs. Moreover, the effect of process variations on the reference signal has not been discussed in detail. To solve these problems, I and my colleagues reported new voltage and current reference circuits [13; 18] that can operate with sub-microwatt power dissipation and with low sensitivity to temperature and supply voltage. Our circuits consist of subthreshold MOSFET circuits and use no resistors.
Bullying and Victimization in Adolescence: Concurrent and Stable Roles and Psychological Health Symptoms

From an initial sample of 1,278 Italian students, the authors selected 537 on the basis of their responses to a self-report bully and victim questionnaire. Participants' ages ranged from 13 to 20 years (M = 15.12 years, SD = 1.08 years). The authors compared the concurrent psychological symptoms of 4 participant groups (bullies, victims, bully/victims [i.e., bullies who were also victims of bullying], and uninvolved students). Of participants, 157 were in the bullies group, 140 were in the victims group, 81 were in the bully/victims group, and 159 were in the uninvolved students group. The results show that bullies reported a higher level of externalizing problems, victims reported more internalizing symptoms, and bully/victims reported both a higher level of externalizing problems and more internalizing symptoms. The authors divided the sample into 8 groups on the basis of the students' recollection of their earlier school experiences and of their present role. The authors classified the participants as stable versus late bullies, victims, bully/victims, or uninvolved students. The authors compared each stable group with its corresponding late group and found that stable victims and stable bully/victims reported higher degrees of anxiety, depression, and withdrawal than did the other groups. The authors focus their discussion on the role of chronic peer difficulties in relation to adolescents' symptoms and well-being.
Reactive oxygen species are signalling molecules for skeletal muscle adaptation

Increased reactive oxygen species (ROS) production is crucial to the remodelling that occurs in skeletal muscle in response to both exercise training and prolonged periods of disuse. This review discusses the redox‐sensitive signalling pathways that are responsible for this ROS‐induced skeletal muscle adaptation. We begin with a discussion of the sites of ROS production in skeletal muscle fibres. This is followed by an overview of the putative redox‐sensitive signalling pathways that promote skeletal muscle adaptation. Specifically, this discussion highlights redox‐sensitive kinases, phosphatases and the transcription factor nuclear factor‐κB. We also discuss the evidence that connects redox signalling to skeletal muscle adaptation in response to increased muscular activity (i.e. exercise training) and during prolonged periods of muscular inactivity (i.e. immobilization). In an effort to stimulate further research, we conclude with a discussion of unanswered questions about redox signalling in skeletal muscle.
The Influence of Parenting Style on Adolescent Competence and Substance Use

An overview of the Family Socialization and Developmental Competence longitudinal program of research (FSP) is followed by a presentation of the hypotheses and findings pertaining to family patterns as determinants of adolescent competence, and of types of adolescent substance users. Data include clusters derived from comprehensive ratings of parents and their children completed independently within- and across-time periods at ages 4, 9, and 15 years. At Time 3 (T3), the sample included 139 adolescents and their parents from a predominantly affluent, well-educated, Caucasian population. Parenting types were identified that differ on the bases of commitment and balance of demandingness and responsiveness. Authoritative parents who are highly demanding and highly responsive were remarkably successful in protecting their adolescents from problem drug use, and in generating competence. Authoritative upbringing, although sufficient, is not a necessary condition to produce competent children. Casual recreational drug use was not associated with pathological attributes, either precursive or concurrent, although nonusers showed an increment in competence from Time 2 (T2) to Time 3 (T3).
National Cultures, Values and Lifestyles Influencing Consumers' Perception towards Sexual Imagery in Alcohol Advertising: An Exploratory Study in the UK, Germany and Italy

This exploratory study examines consumers' perception towards sexual imagery in alcohol advertising across national cultures and among men and women with different demographic and psychographic make-up in those cultures. This study addresses a very important gap found in the literature, namely the influence of consumers' psychographic characteristics as values and lifestyles on their overall perception towards sexual imagery in advertising. The study was conducted among consumers aged between 18 and 35 in the United Kingdom, Germany and Italy. Results indicate that Italians overall have higher acceptance levels towards sexual imagery portrayed in advertisements as compared to German and British consumers. Furthermore, varying levels of sexual imagery are much more appealing to men than women in all three countries. Consumers' values and lifestyles also played an important role in their overall perception. Moral values in particular are an indicator of acceptance levels of sexual content.
Pre-service teachers’ assessment literacy and its implementation into practice

This research study was conducted to address pre-service physics teachers’ assessment literacy and its implementation into practice. The research was both quantitative and qualitative in nature. For the quantitative aspect of the study, the researchers determined the participants’ assessment literacy after their enrolment with the assessment course. Intentions of the qualitative part were to validate the results drawn from the quantitative research and to examine the participants’ assessment literacy in the practical realm. Data were collected by using a valid and reliable instrument developed by the first author, a questionnaire and the participants’ project assignment including implementation of assessment. According to the quantitative results, the pre-service physics teachers’ assessment literacy was quite high. Findings obtained from the qualitative analyses were compatible with the quantitative results. However, the study revealed gaps between assessment literacy in theory and practice. This study suggests that teacher education programmes should highlight theories of assessment as well as types of evaluation, stress validity and reliability of assessment enabling students to engage in both traditional and performance-based assessment methods, and provide opportunities for students to reflect, practice, and revise these methods.
Associations of Body Mass Index and Gestational Weight Gain with Term Pregnancy Outcomes

Introduction: Obesity is one of the greatest health problems in the world. The World Health Organization (WHO) defined obesity as a disease in which the excess of adipose tissue accumulates in such a degree that is endangers health. Obesity is a very complex multifactor disease that is developed under the influence of genetic and metabolic factors, environment, social and cultural environment as well as bad habits. The causes of obesity can be numerous. The most common source of obesity is the development of energetic imbalance. Material and methods: A retrospective study of medical records in the Department of Obstetrics and Gynecology, University Clinical Hospital in Mostar was conducted. It included 1300 pregnant women and their children that were delivered in the time period from January 1st 2015 to December 31st 2015. It was conducted a retrospective study which involved 1300 pregnant women who gave births in the Department of Obstetrics and Gynecology of University Clinical Hospital in Mostar in the period from January 1st 2015 to December 31st 2015 and their newborns. Results: The difference in age of pregnant women with different body mass index was not statistically relevant. The average age of pregnant women with normal body mass was 29.52 ± 5.48, overweight pregnant women 30.30 ± 5.138, and obese pregnant women 30.00 ± 5.103 (F = 2.730; p = 0.066). The youngest was 24, and the oldest was 49 years old. The average gestational age at delivery was 39.23 ± 1.556 (min 28; max. 42 weeks of gestation). The majority of pregnant women; 660 of them (50.8 %), were overweight in the early stages of their pregnancy, there were 322 (24.8 %) obese women, and there were 318 (24.5 %) normal weight women. At the end of the pregnancy, the highest number was that of obese pregnant women 925 (71.2 %), while 328 (25.2 %) pregnant women were overweight, and only 47 (3.6 %) pregnant women had normal weight. Conclusion: Nutritive status and weight gain of a mother during pregnancy are an important indication of her health and of the foetus growth. Overweightness and obesity of a mother before pregnancy and during pregnancy has a negative influence on the health of the mother and infant. Moreover, it is linked with risk and a negative pregnancy outcome. BMI was associated with an increased risk of adverse perinatal outcome.