Miracle-dz/UniFAR-FTUs huggingface dataset:
Fluoroscopic Caudal Epidural Injections in Managing Post Lumbar Surgery Syndrome: Two-Year Results of a Randomized, Double-Blind, Active-Control Trial

Study Design: A randomized, active control, double-blind trial. Objective: To evaluate the effectiveness of fluoroscopically directed caudal epidural injections with or without steroids in managing chronic low back and lower extremity pain secondary to post lumbar surgery syndrome. Summary of Background Data: There is a paucity of evidence concerning caudal epidural injections for managing chronic persistent low back pain with or without lower extremity pain caused by post lumbar surgery syndrome. Methods: This active control randomized study included 140 patients with 70 patients in each group. Group I received 0.5% lidocaine, 10 mL; Group II received 9 mL of 0.5% lidocaine mixed with 1 mL of 6 mg of nonparticulate betamethasone. The multiple outcome measures included the numeric rating scale, the Oswestry Disability Index 2.0, employment status, and opioid intake with assessments at 3, 6, 12, 18, and 24 months posttreatment. Primary outcome was defined as at least 50% improvement in pain and Oswestry Disability Index scores. Patients with a positive response to the first 2 procedures with at least 3 weeks of relief were considered to be successful. All others were considered as failures. Results: Overall in Group I, 53% and 47% of the patients and in Group II, 59% and 58% of the patients, showed significant improvement with reduction in pain scores and disability index at 12 months and 24 months. In contrast, in the successful groups, significant pain relief and improvement in function were observed in 70% and 62% of Group I at one and 2 years; in 75% and 69% of Group II at one and 2 years. The results in the successful group showed that at the end of the first year patients experienced approximately 38 weeks of relief and at the end of 2 years Group I had 62 weeks and Group II had 68 weeks of relief. Overall total relief for 2 years was 48 weeks in Group I and 54 weeks in Group II. The average procedures in the successful groups were at 4 in one year and 6 at the end of 2 years. Conclusion: Caudal epidural injections of local anesthetic with or without steroid might be effective in patients with chronic persistent low back and/or lower extremity pain in patients with post lumbar surgery syndrome.
On the Effective Configuration of Planning Domain Models

The development of domain-independent planners within the AI Planning community is leading to "off the shelf" technology that can be used in a wide range of applications. Moreover, it allows a modular approach - in which planners and domain knowledge are modules of larger software applications - that facilitates substitutions or improvements of individual modules without changing the rest of the system. This approach also supports the use of reformulation and configuration techniques, which transform how a model is represented in order to improve the efficiency of plan generation. In this paper, we investigate how the performance of planners is affected by domain model configuration. We introduce a fully automated method for this configuration task, and show in an extensive experimental analysis with six planners and seven domains that this process (which can, in principle, be combined with other forms of reformulation and configuration) can have a remarkable impact on performance across planners. Furthermore, studying the obtained domain model configurations can provide useful information to effectively engineer planning domain models.
Goal Achievement: The Role of Intentions

The intention-to-behavior process is analyzed with respect to implementation intentions. These intentions link an intended goal-directed behavior to an anticipated situational context. The reported experimental evidence suggests that implementation intentions create a heightened accessibility of the mental representation of the specified situational cues and induce direct (automatic) control of the intended behavior through these cues. The formation of implementation intentions promotes goal achievement through both of these processes because they eliminate classic problems associated with the control of goal-directed action. Similarities and differences to other theoretical approaches on intentions, planning, and action control are discussed.
A R2R3-type MYB gene, OsMYB2, is involved in salt, cold, and dehydration tolerance in rice

MYB-type transcription factors play a diverse role in plant development and response to abiotic stress. This study isolated a rice R2R3-type MYB gene, OsMYB2, and functionally characterized its role in tolerance to abiotic stress by generating transgenic rice plants with overexpressing and RNA interference OsMYB2. Expression of OsMYB2 was up-regulated by salt, cold, and dehydration stress. OsMYB2 was localized in the nucleus with transactivation activity. No difference in growth and development between the OsMYB2-overexpressing and wild-type plants was observed under normal growth conditions, but the OsMYB2-overexpressing plants were more tolerant to salt, cold, and dehydration stresses and more sensitive to abscisic acid than wild-type plants. The OsMYB2-overexpressing plants accumulated greater amounts of soluble sugars and proline than wild-type plants under salt stress. Overexpression of OsMYB2 enhanced up-regulation of genes encoding proline synthase and transporters. The OsMYB2-overexpressing plants accumulated less amounts of H2O2 and malondialdehyde. The enhanced activities of antioxidant enzymes, including peroxidase, superoxide dismutase, and catalase, may underlie the lower H2O2 contents in OsMYB2-overexpressing plants. There was greater up-regulation of stress-related genes, including OsLEA3, OsRab16A, and OsDREB2A, in the OsMYB2-overexpressing plants. Microarray analysis showed that expression of numerous genes involving diverse functions in stress response was altered in the OsMYB2-overexpressing plants. These findings suggest that OsMYB2 encodes a stress-responsive MYB transcription factor that plays a regulatory role in tolerance of rice to salt, cold, and dehydration stress.
Hsp90 Interactions and Acylation Target the G Protein Gα12 but Not Gα13 to Lipid Rafts*

The heterotrimeric G proteins, G12and G13, are closely related in their sequences, signaling partners, and cellular effects such as oncogenic transformation and cytoskeletal reorganization. Yet G12 and G13can act through different pathways, bind different proteins, and show opposing actions on some effectors. We investigated the compartmentalization of G12 and G13 at the membrane because other G proteins reside in lipid rafts, membrane microdomains enriched in cholesterol and sphingolipids. Lipid rafts were isolated after cold, nonionic detergent extraction of cells and gradient centrifugation. Gα12 was in the lipid raft fractions, whereas Gα13 was not associated with lipid rafts. Mutation of Cys-11 on Gα12, which prevents its palmitoylation, partially shifted Gα12 from the lipid rafts. Geldanamycin treatment, which specifically inhibits Hsp90, caused a partial loss of wild-type Gα12 and a complete loss of the Cys-11 mutant from the lipid rafts and the appearance of a higher molecular weight form of Gα12 in the soluble fractions. These results indicate that acylation and Hsp90 interactions localized Gα12 to lipid rafts. Hsp90 may act as both a scaffold and chaperone to maintain a functional Gα12 only in discrete membrane domains and thereby explain some of the nonoverlapping functions of G12 and G13 and control of these potent cell regulators.
Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells

The development of Imatinib mesylate (IM), which targets the oncogenic BCR-ABL fusion protein, has greatly improved the outcome of Chronic Myeloid Leukemia (CML) patients. However, BCR-ABL–positive progenitors can be detected in CML patients in complete cytogenetic response. Several evidence suggests that CML stem cells are intrinsically resistant to Tyrosine Kinase Inhibitors (TKI), and therefore they represent the most likely candidate responsible for disease relapse. In this work, we investigated the microRNA (miRNA) expression profile of different subpopulations of CML Leukemic Stem Cells (LSCs): Lin-CD34+CD38- and Lin-CD34-CD38- cells. These cell fractions have been previously shown to be endowed with TKI intrinsic resistance. Our analysis identified 33 common deregulated miRNAs in CML LSCs. Among those, 8 miRNAs were deregulated in CML independently from BCR-ABL kinase activity and therefore are likely to be involved in the BCR-ABL-independent resistance to TKI that characterizes CML LSCs. In particular, the up-regulation of miR-29a-3p and miR-660-5p observed in CML LSCs, led to the down-regulation of their respective targets TET2 and EPAS1 and conferred TKI-resistance to CML LSCs in vitro. On the other hand, miR-494-3p down-regulation in CML LSCs, leading to c-MYC up-regulation, was able to decrease TKI-induced apoptosis. These results demonstrate that aberrant miRNA expression in CML LSCs could contribute to the intrinsic TKI-resistance observed in these cell populations, and support the development of novel therapies aimed at targeting aberrantly regulated miRNAs or their targets in order to effectively eradicate CML LSCs.
Variable parathyroid hormone(1-84)/carboxylterminal PTH ratios detected by 4 novel parathyroid hormone assays.

AIM Parathyroidhormone (PTH) measurement is important in the evaluation of bone disease in patients with chronic renal failure. Large carboxyl-terminal PTH fragments (C-PTH) cross-react with second-generation PTH assays, lead to an overestimation of biologically active PTH, and are evaluated by a combination of second- and third-generation PTH assays. The aim of our study was to examine whether the use of 4 different PTH assays of putatively same specificity leads to comparable results detecting C-PTH fragments. SUBJECTS AND METHODS In 70 chronic dialysis patients, total PTH and PTH(1-84) were measured in parallel by 4 novel PTH assays (Nichols Advantage Intact PTH and Bio-Intact PTH Chemiluminescence Assay, Nichols Institute Diagnostics, USA, DUO Total and CAP PTH IRMA, Scantibodies Laboratory, USA). The C-PTH concentration was quantitated by subtracting PTH(1-84) from total PTH. Consecutively, the PTH(1-84)/C-PTH ratio was calculated. RESULTS Nichols Intact PTH and DUO Total PTH assays were highly correlated (r = 0.985), as well as Nichols Bio-Intact and DUO CAP assays (r = 0.984). However, total PTH values measured by the Nichols assay were 30% higher (median (range): 185 (9.9 - 2,332) versus 130 (2.3 - 1,271.1) pg/ml, p < 0.01). PTH(1-84) values, measured by the Nichols Bio-Intact PTH assay were 8% higher compared to the Scantibodies CAP assay (median (range): 79.6 (7.5 - 1,060.9) versus 73.7 (4.4 - 918.9) pg/ml, p = NS). Thirty-six patients had a ratio < 1 measured by the Nichols assays, whereas only 8 patients showed the same ratio when measured by the Scantibodies assays. In 28 patients (40%), contradictory PTH(1-84)/C-PTH ratios were found, showing a ratio < 1 when measured by the Nichols assays, but > 1 when the Scantibodies assays were used. CONCLUSION In conclusion, our results suggest that the PTH(1-84)/C-PTH ratio cannot be equally used as a predictor of bone turnover when different PTH assays are used. Depending on those assays, differences in total PTH values mathematically lead to varying amounts of C-PTH fragments resulting in variable, even contradictory PTH(1-84)/C-PTH ratios.
Effects of the Asynchronous Web-Based Course: Preservice Teachers' Achievement, Metacognition, and Attitudes towards the Course

This present study aimed to investigate the effects of the asynchronous web-based "General Teaching Methods" course conducted based on direct or indirect instructional methods on pre-service teachers' achievement, metacognition, and attitudes towards web-based course. Two groups, a total of 63 third grade elementary science and mathematics education pre-service teachers, attended to one of the aforementioned web-based courses. The results indicated that the group exposed to the web-based indirect instruction significantly outperformed the group exposed to the web-based direct instruction in the final exam but not in the midterm exam and in the metacognitive questionnaire. On the other hand, the group exposed to the web-based direct instruction had significantly higher attitudes towards web-based course than the one exposed to the web-based indirect instruction.
In-group favoritism and statistical reasoning in social inference : implications for formation and maintenance of group stereotypes

The effects of group categorization on statistical inference processes and the consequent effects on group stereotyping were examined in 3 experiments. In Experiments 1 and 2, male and female Ss made data-based judgments about gender and leadership ability. In Experiment 3, Ss were randomly categorized into groups and then made data-based judgments about the groups'relative intelligence. Results from all 3 studies indicated significant effects of group categorization on Ss' judgments and on their strategies of data integration and logical inference
Alexithymia and fear of pain independently predict heat pain intensity ratings among undergraduate university students.

BACKGROUND Alexithymia is a disturbance in awareness and cognitive processing of affect that is associated with over-reporting of physical symptoms, including pain. The relationship between alexithymia and other psychological constructs that are often associated with pain has yet to be evaluated. OBJECTIVES The present study examined the importance of alexithymia in the pain experience in relation to other integral psychological components of Turk's diathesis-stress model of chronic pain and disability, including fear of pain, anxiety sensitivity, pain avoidance and pain catastrophizing. METHODS Heat pain stimuli, using a magnitude estimation procedure, and five questionnaires (Anxiety Sensitivity Index, Fear of Pain Questionnaire III, Pain Catastrophizing Scale, avoidance subscale of the Pain Anxiety Symptoms Scale-20 and Toronto Alexithymia Scale-20) were administered to 67 undergraduate students (44 women) with a mean (+/- SD) age of 20.39+/-3.77 years. RESULTS Multiple linear regression analysis revealed that sex, fear of pain and alexithymia were the only significant predictors of average heat pain intensity (F[6, 60]=5.43; R2=0.35; P=0.008), accounting for 6.8%, 20.0% and 9.6% of unique variance, respectively. Moreover, the difficulty identifying feelings and difficulty describing feelings subscales, but not the externally oriented thinking subscale of the Toronto Alexithymia Scale-20 significantly predicted average heat pain intensity. CONCLUSIONS Individuals with higher levels of alexithymia or increased fear of pain reported higher average pain intensity ratings. The relationship between alexithymia and pain intensity was unrelated to other psychological constructs usually associated with pain. These findings suggest that difficulties with emotion regulation, either through reduced emotional awareness via alexithymia or heightened emotional awareness via fear of pain, may negatively impact the pain experience.
Nocturnal periodic breathing during acclimatization at very high altitude at Mount Muztagh Ata (7,546 m).

RATIONALE Quantitative data on ventilation during acclimatization at very high altitude are scant. Therefore, we monitored nocturnal ventilation and oxygen saturation in mountaineers ascending Mt. Muztagh Ata (7,546 m). OBJECTIVES To investigate whether periodic breathing persists during prolonged stay at very high altitude. METHODS A total of 34 mountaineers (median age, 46 yr; 7 women) climbed from 3,750 m within 19-20 days to the summit at 7,546 m. During ascent, repeated nocturnal recordings of calibrated respiratory inductive plethysmography, pulse oximetry, and scores of acute mountain sickness were obtained. MEASUREMENTS AND MAIN RESULTS Nocturnal oxygen saturation decreased, whereas minute ventilation and the number of periodic breathing cycles increased with increasing altitude. At the highest camp (6,850 m), median nocturnal oxygen saturation, minute ventilation, and the number of periodic breathing cycles were 64%, 11.3 L/min, and 132.3 cycles/h. Repeated recordings within 5-8 days at 4,497 m and 5,533 m, respectively, revealed increased oxygen saturation, but no decrease in periodic breathing. The number of periodic breathing cycles was positively correlated with days of acclimatization, even when controlled for altitude, oxygen saturation, and other potential confounders, whereas symptoms of acute mountain sickness had no independent effect on periodic breathing. CONCLUSIONS Our field study provides novel data on nocturnal oxygen saturation, breathing patterns, and ventilation at very high altitude. It demonstrates that periodic breathing increases during acclimatization over 2 weeks at altitudes greater than 3,730 m, despite improved oxygen saturation consistent with a progressive increase in loop gain of the respiratory control system. Clinical trial registered with www.clinicaltrials. gov (NCT00514826).
Multiple-sink placement strategies in wireless sensor networks

Multiple sinks are deployed in large-scale wireless sensor networks (WSNs) to minimize transmission delay and energy consumption and also to extend the network life time. Since the data collected by sensor nodes are forwarded to the sink, therefore proper placement of sinks has a great impact on the performance of the WSNs. This paper introduces two sink placement strategies and discusses their advantages and disadvantages in comparison with an existing strategy. The two strategies are compared with the Geographic Sink Placement (GSP) [3] strategy which is used as a benchmark. Both GSP and proposed two strategies are implemented and evaluated in a simulation environment. Performances of these strategies are analyzed and analysis results are presented in this paper. It has been observed that the proposed strategies exhibit better performances with respect to energy usage and lifetime in comparison with GSP.
War and children's aggressive and prosocial behaviour

The aim of this study was to investigate whether, and how, extreme environmental influence, such as a war situation, can affect the development of children's aggressive and prosocial behaviour. A combined longitudinal–cross‐sectional design was used in the study. Subjects were preschool children whose behaviour was rated on the Children's Aggressive and Prosocial Behaviour Rating Scale (Žužul, Keresteš and Vlahović‐štetić, 1990) by their teachers. At the beginning of 1991 (before the war in Croatia started) the behaviour of two groups of children (one five years old and one six years old) was assessed. One year later, the younger group was assessed again. Another group of five‐year‐old children was also included and rated at the same time. Data were analysed according to age, sex and the time of measurements. The analyses of longitudinal data and cross‐sectional comparisons support the conclusion that the war had a strong impact on the development of prosocial behaviour. In this period, children's prosocial behaviour had increased, while aggressive behaviour had not changed. Results are discussed in terms of developmental changes and the effects of war on children's behaviour.
Do Foreign Firms Really Pay Higher Wages? Evidence from Different Estimators

We contribute to the literature on Foreign Direct Investment and labour markets by examining wage differentials between domestic and foreign firms, drawing on a large Portuguese matched employer-employee panel. Using OLS, the foreign-firm premium is large and significantly positive but falls substantially when firm and worker controls are added. Moreover, the premium also does not vary monotonically with foreign control, it increases along the wage distribution and it is generally insignificant when using propensity score matching. Finally, using differences-in-differences, we find lower wage growth for workers in domestic firms that are acquired by foreign investors, a result that holds when combining differences-in-differences and propensity score matching. Overall, our evidence suggests that the commonly-documented OLS premium cannot be interpreted as a causal impact.
Facilitators of Organizational Learning in Design.

Purpose – The purpose of this paper is to determine the influence of organizational factors such as leadership commitment, incentives and interaction on learning outcomes defined as performance improvement and organizational climate.Design/methodology/approach – Different aspects of knowledge acquisition, sharing and utilization were examined, related to outcomes. Design professionals in Vietnam construction firms were surveyed. The sample was 339 designers.Findings – The impact of leadership commitment was significantly related to both performance and organizational climate. Incentives were only positively correlated with performance and staff interaction was only positive with organizational climate. The paper is supportive of many conceptual studies in the literature. The results show that each of these factors has a different role and impact on the organizational learning process and outcome.Research limitations/implications – The limitations of this study are that the sample comes from only one indus.
Interactive Lighting Design with Hierarchical Light Representation

Lighting design plays a crucial role in indoor lighting design, computer cinematograph and many other applications. Computer‐assisted lighting design aims to find a lighting configuration that best approximates the illumination effect specified by designers. In this paper, we present an automatic approach for lighting design, in which discrete and continuous optimization of the lighting configuration, including the number, intensity, and position of lights, are achieved. Our lighting design algorithm consists of two major steps. The first step estimates an initial lighting configuration by light sampling and clustering. The initial light clusters are then recursively merged to form a light hierarchy. The second step optimizes the lighting configuration by alternatively selecting a light cut on the light hierarchy to determine the number of representative lights and optimizing the lighting parameters using the simplex method. To speed up the optimization computation, only illumination at scene vertices that are important to rendering are sampled and taken into account in the optimization. Using the proposed approach, we develop a lighting design system that can compute appropriate lighting configurations to generate the illumination effects iteratively painted and modified by a designer interactively.
From Intentions to Behavior: Implementation Intention, Commitment, and Conscientiousness

Implementation intentions are said to transfer control over goal-directed behavior to situational cues, thereby automating initiation of the behavior (Gollwitzer, 1999). Alternatively, implementation intentions may be effective because they create commitment to the intended behavior. In an empirical study, implementation intentions regarding a simple task (rating TV newscasts) varied in their specificity. In addition, explicit commitment to the task was manipulated, and chronic conscientiousness was assessed. Consistent with the commitment hypothesis, general and specific implementation intentions were equally effective in raising level of task performance, and they were no more effective than asking for an explicit commitment to carry out the task. Also, individuals high in conscientiousness were more likely than individuals low on this trait to enact their intentions. jasp_485 1356.1372