Miracle-dz/UniFAR-FTUs huggingface dataset:
The Giant Submarine Alika Debris Slide, Mauna Loa, Hawaii

probably represent multiple subsidence events before, during, and after the debris avalanches. Lower slopes of the slide contain distinctive lobate-terraced deposits that are interpreted as having been emplaced more slowly, prior to the debris avalanches. Estimated thicknesses of 50-200 m suggest volumes of 200--600 km 3 for the two lobes. The combined volume of the entire slide and slump terrane is probably 1500-2000 km 3. The slide deposits predate a 13-ka coral reef and probably postdate the block-faulted Ninole Basalt, roughly dated as a few hundred thousand years old. The Alika slide, or a similar deposit recognized on GLORIA images further north along the Hawaiian Ridge, probably triggered a giant wave that washed 325 m high on Lanai at about 100 ka. Slumping on Mauna Loa has been most intense adjacent to the large arcuate bend in its southwest rift zone, as the rift zone migrated westward away from the growing Kilauea volcano. Slumping events were probably triggered by seismic activity accompanying dike injection along the rift zone. Such massive slumps, landslides, and distal submarine turbidity flows appear to be widespread on the flanks of Hawaiian volcanoes.
State Policy Mood

Recently, we introduced and validated annual state-level estimates of the public’s policy mood and party identification from 1956 to 2010 and self-identified political ideology from 1976 to 2010. In this issue, Berry, Ringquist, Fording, and Hanson (BRFH) compare our measure of policy mood with a measure they created, and they conclude that their measure is “the best available indicator of state policy mood for researchers doing pooled cross-sectional time-series analysis. ” In this article, we show that BRFH’s skepticism of our measure and confidence in their measure result from a failure to fully consider over-time dynamics. When we consider over-time variation, the Enns and Koch measure of policy mood continues to perform well. By contrast, some concerning patterns emerge with the BRFH measure. In addition to further validating the Enns and Koch measure, this article speaks to similarities in opinion change across states and offers initial evidence of an over-time relationship between state policy mood and state spending priorities.
‘Football Fitness’: constraining and enabling possibilities for the management of leisure time for women

ABSTRACT The aim of the article is to identify constraining and enabling aspects for the management of leisure time for women participating in ‘Football Fitness’, a new ‘sport for all programme’ carried out in associative sport clubs in Denmark. The article is based on six focus group interviews with white, middle-class female participants (N = 32, aged 27–56). An analysis combining Hochschild’s conceptualization of the second and third shift [1989. The Second Shift. New York: Avon] with Elias and Dunning’s perspective on leisure as part of the spare-time spectrum and leisure sport as a quest for excitement [1986. Quest for Excitement. Sport and Leisure in the Civilizing Process. New York: Basil Blackwell] demonstrates that leisure sport participation must be understood in relation to both spare time, family life, and work life, as these spheres are interrelated. According to the women, both doing and planning housework are constraining for their leisure sport participation. On the other hand, Football Fitness is enabling in the sense that the women experience it as something pleasurable and a ‘free space’.
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood–Brain Barrier Integrity

Circular RNAs (circRNAs) are highly expressed in the CNS and regulate physiological and pathophysiological processes. However, the potential role of circRNAs in stroke remains largely unknown. Here, we show that the circRNA DLGAP4 (circDLGAP4) functions as an endogenous microRNA-143 (miR-143) sponge to inhibit miR-143 activity, resulting in the inhibition of homologous to the E6-AP C-terminal domain E3 ubiquitin protein ligase 1 expression. circDLGAP4 levels were significantly decreased in the plasma of acute ischemic stroke patients (13 females and 13 males) and in a mouse stroke model. Upregulation of circDLGAP4 expression significantly attenuated neurological deficits and decreased infarct areas and blood–brain barrier damage in the transient middle cerebral artery occlusion mouse stroke model. Endothelial-mesenchymal transition contributes to blood–brain barrier disruption and circDLGAP4 overexpression significantly inhibited endothelial-mesenchymal transition by regulating tight junction protein and mesenchymal cell marker expression. Together, the results of our study are illustrative of the involvement of circDLGAP4 and its coupling mechanism in cerebral ischemia, providing translational evidence that circDLGAP4 serves as a novel therapeutic target for acute cerebrovascular protection. SIGNIFICANCE STATEMENT Circular RNAs (circRNAs) are involved in the regulation of physiological and pathophysiological processes. However, whether circRNAs are involved in ischemic injury, particularly cerebrovascular disorders, remains largely unknown. Here, we demonstrate a critical role for circular RNA DLGAP4 (circDLGAP4), a novel circular RNA originally identified as a sponge for microRNA-143 (miR-143), in ischemic stroke outcomes. Overexpression of circDLGAP4 significantly attenuated neurological deficits and decreased infarct areas and blood–brain barrier damage in the transient middle cerebral artery occlusion mouse stroke model. To our knowledge, this is the first report describing the efficacy of circRNA injection in an ischemic stroke model. Our investigation suggests that circDLGAP4 may serve as a novel therapeutic target for acute ischemic injury.
Independent Vesicle Pools Underlie Different Modes of Release during Neuronal Development

Mature presynaptic terminals release neurotransmitter both in response to activity and spontaneously. We found that axons of rat hippocampal neurons initially show very high levels of exclusively spontaneous release, which progressively switches over to the mature phenotype during synapse formation. These two modes of vesicle cycling derive from distinct pools throughout development and the initiation of activity-dependent release was independent of postsynaptic contacts, suggesting it is an autonomous presynaptic event.
The influence of lunar phases on the occurrence of myocardial infarction: fact or myth? The MONICA/KORA Myocardial Infarction Registry

Aims: The potential influence of lunar phases on the occurrence of myocardial infarction is still controversial. The purpose of the present study was to investigate the association of the lunar cycle on the occurrence of fatal and non-fatal myocardial infarction based on a myocardial infarction registry. Methods and results: We studied 15,985 patients consecutively hospitalised with an acute myocardial infarction (AMI) between 1 January 1985 and 31 December 2007 with a known date of symptom onset who were recruited from a population-based myocardial infarction registry. The exact hour of AMI onset was known for 9813 events. Poisson regression analysis was performed to examine the relation between the lunar cycle and the occurrence of AMI. There was no association between new moon, full moon, waning moon and waxing moon and the occurrence of AMI. However, we observed that the three days after a new moon may be significantly protective for the occurrence of AMI, rate ratio (RR) 0.94 (95% CI 0.91–0.98), and the day before a new moon had a slightly negative effect (RR 1.06, 95% CI 1.00–1.12). Stratified analysis did not reveal any susceptible subgroups. Conclusion: The moon phases did not show any apparent association with AMI occurrence. However, there might be a ‘cardioprotective’ time three days after a new moon.
Control as a Motivation for Underpricing: A Comparison of Dual- and Single-Class Ipos

We find that dual-class firms experience less underpricing, higher post-IPO institutional ownership, and less frequent control events than single-class firms. Each finding is consistent with the "reduced monitoring hypothesis" of Brennan and Franks (1997), which explains underpricing as a mechanism by which insiders create dispersion in the post-IPO ownership structure. By separating cash flow and voting rights, dual-class managers can raise capital without sacrificing control. Having ensured voting control, dual-class issuers have no incentive to underprice to limit large shareholders' post-IPO monitoring. Although dual-class firms achieve a lower underpricing cost relative to single-class firms, they trade at lower pricing multiples.
On the mechanism of G protein beta gamma subunit activation of the muscarinic K+ channel in guinea pig atrial cell membrane. Comparison with the ATP-sensitive K+ channel

The mechanism of G protein beta gamma subunit (G beta gamma)-induced activation of the muscarinic K+ channel (KACh) in the guinea pig atrial cell membrane was examined using the inside-out patch clamp technique. G beta gamma and GTP-gamma S-bound alpha subunits (G alpha *'s) of pertussis toxin (PT)-sensitive G proteins were purified from bovine brain. Either in the presence or absence of Mg2+, G beta gamma activated the KACh channel in a concentration-dependent fashion. 10 nM G beta gamma almost fully activated the channel in 132 of 134 patches (98.5%). The G beta gamma-induced maximal channel activity was equivalent to or sometimes larger than the GTP-gamma S-induced one. Half-maximal activation occurred at approximately 6 nM G beta gamma. Detergent (CHAPS) and boiled G beta gamma preparation could not activate the KACh channel. G beta gamma suspended by Lubrol PX instead of CHAPS also activated the channel. Even when G beta gamma was pretreated in Mg(2+)-free EDTA internal solution containing GDP analogues (24-48 h) to inactivate possibly contaminating G i alpha *'s, the G beta gamma activated the channel. Furthermore, G beta gamma preincubated with excessive GDP-bound G o alpha did not activate the channel. These results indicate that G beta gamma itself, but neither the detergent CHAPS nor contaminating G i alpha *, activates the KACh channel. Three different kinds of G i alpha * at 10 pM-10 nM could weakly activate the KACh channel. However, they were effective only in 40 of 124 patches (32.2%) and their maximal channel activation was approximately 20% of that induced by GTP-gamma S or G beta gamma. Thus, G i alpha * activation of the KACh channel may not be significant. On the other hand, G i alpha *'s effectively activated the ATP-sensitive K+ channel (KATP) in the ventricular cell membrane when the KATP channel was maintained phosphorylated by the internal solution containing 100 microM Mg.ATP. G beta gamma inhibited adenosine or mACh receptor-mediated, intracellular GTP-induced activation of the KATP channel. G i alpha *'s also activated the phosphorylated KATP channel in the atrial cell membrane, but did not affect the background KACh channel. G beta gamma subsequently applied to the same patch caused prominent KACh channel activation. The above results may indicate two distinct regulatory systems of cardiac K+ channels by PT-sensitive G proteins: G i alpha activation of the KATP channel and G beta gamma activation of the KACh channel.
Contact-based navigation for an autonomous flying robot

Autonomous navigation in obstacle-dense indoor environments is very challenging for flying robots due to the high risk of collisions, which may lead to mechanical damage of the platform and eventual failure of the mission. While conventional approaches in autonomous navigation favor obstacle avoidance strategies, recent work showed that collision-robust flying robots could hit obstacles without breaking and even self-recover after a crash to the ground. This approach is particularly interesting for autonomous navigation in complex environments where collisions are unavoidable, or for reducing the sensing and control complexity involved in obstacle avoidance. This paper aims at showing that collision-robust platforms can go a step further and exploit contacts with the environment to achieve useful navigation tasks based on the sense of touch. This approach is typically useful when weight restrictions prevent the use of heavier sensors, or as a low-level detection mechanism supplementing other sensing modalities. In this paper, a solution based on force and inertial sensors used to detect obstacles all around the robot is presented. Eight miniature force sensors, weighting 0.9g each, are integrated in the structure of a collision-robust flying platform without affecting its robustness. A proof-of-concept experiment demonstrates the use of contact sensing for exploring autonomously a room in 3D, showing significant advantages compared to a previous strategy. To our knowledge this is the first fully autonomous flying robot using touch sensors as only exteroceptive sensors.
Renal Dysfunction, CHADS2 Score, and Adherence to the Anticoagulant Treatment in Nonvalvular Atrial Fibrillation

We investigated the risk of stroke associated with renal dysfunction and the impact of warfarin therapies in Chinese patients with nonvalvular atrial fibrillation (NVAF). Information was collected on age, sex, height, weight, type of atrial fibrillation, and serum creatinine within the previous 6 months, together with the variables needed to calculate the CHADS2 score. For patients not taking warfarin, reasons why not were recorded. Three thousand seventeen eligible patients with NVAF, mean (1 standard deviation [SD]) age of 67.7 (13.0) years, from 50 Chinese hospitals were included from May 2012 to October 2012, with a mean (1SD) CHADS2 score of 2.0 (1.5). Of these, 58.3% were male and 86.2% were at high risk of stroke with a CHADS2 score ≥1. Only 42.6% were on warfarin, and 22.5% of the patients had moderate or severe renal impairment (estimated glomerular filtration rate < 60 mL/min/1.73 m2). After adjustment for the CHADS2 score, renal dysfunction remained moderately but significantly associated with the risk of stroke/TIA (odds ratio = 1.005, 95% confidence interval: 1.002-1.009, P = .002). There was, however, no significant difference in anticoagulant usage between patients with or without impaired renal dysfunction. The most common anticoagulant concerns were the low proportion of patients with regular international normalized ratio monitoring (43.0%) and the risk of bleeding (33.3%). Renal impairment was common and independently associated with the risk of cerebrovascular embolism in Chinese patients with NVAF but not independently related to underuse of anticoagulant treatment.
Error monitoring in musicians

To err is human, and hence even professional musicians make errors occasionally during their performances. This paper summarizes recent work investigating error monitoring in musicians, i.e., the processes and their neural correlates associated with the monitoring of ongoing actions and the detection of deviations from intended sounds. Electroencephalography (EEG) studies reported an early component of the event-related potential (ERP) occurring before the onsets of pitch errors. This component, which can be altered in musicians with focal dystonia, likely reflects processes of error detection and/or error compensation, i.e., attempts to cancel the undesired sensory consequence (a wrong tone) a musician is about to perceive. Thus, auditory feedback seems not to be a prerequisite for error detection, consistent with previous behavioral results. In contrast, when auditory feedback is externally manipulated and thus unexpected, motor performance can be severely distorted, although not all feedback alterations result in performance impairments. Recent studies investigating the neural correlates of feedback processing showed that unexpected feedback elicits an ERP component after note onsets, which shows larger amplitudes during music performance than during mere perception of the same musical sequences. Hence, these results stress the role of motor actions for the processing of auditory information. Furthermore, recent methodological advances like the combination of 3D motion capture techniques with EEG will be discussed. Such combinations of different measures can potentially help to disentangle the roles of different feedback types such as proprioceptive and auditory feedback, and in general to derive at a better understanding of the complex interactions between the motor and auditory domain during error monitoring. Finally, outstanding questions and future directions in this context will be discussed.
Peer Monitoring, Eigentümerstruktur und die Stabilität von Banken: Eine empirische Analyse für den deutschen genossenschaftlichen Bankensektor

Eine Gruppe vglw. kleiner Banken mit homogenem Geschaftsmodell ist theoretisch fahig, systemische Risiken freizusetzen. Ein Praventionsmechanismus kann hierbei Marktdisziplinierung sein, der dann irrelevant erscheint, wenn Kreditinstitute nicht auf allgemeinen Interbankenmarkten aktiv sind. Dieses Papier analysiert empirisch inwiefern die genossen-schaftlichen Primarbanken einer Disziplinierung im Rahmen ihres geschlossenen Interbankenmarktes ausgesetzt sind und dessen Effekte auf die Verbundstabilitat unter Berucksichtigung der genossenschaftlichen Eigentumerstruktur. Hierfur werden ein Paneldatensatz von 1.011 deutschen Genossenschaftsbanken uber den Zeitraum 2004-2013 und u.a. dynamische Paneldatenmodelle verwendet. Es sind drei wesentliche Ergebnisse herauszustellen: (i) die genossenschaftlichen Zentralbanken uben aktiv Peer Monitoring aus, welches (ii) sich marginal stabilisierend auf den Verbund auswirkt. Daruber hinaus spielen (iii) die genossenschaftlichen Spezifika eine Rolle bei der Transmission von Stabilitat und Instabilitat, der nicht eindeutig uber Ertragsdiversifikation begegnet werden kann.
Metabolic syndrome in patients enrolled in a clinical trial of aripiprazole in the maintenance treatment of bipolar I disorder: a post hoc analysis of a randomized, double-blind, placebo-controlled trial.

OBJECTIVE To compare the effects of maintenance treatment with aripiprazole or placebo on the incidence of metabolic syndrome in bipolar disorder. METHOD Patients with DSM-IV bipolar I disorder were stabilized on aripiprazole therapy for 6-18 weeks prior to double-blind random assignment to aripiprazole or placebo for 26 weeks. The rate of metabolic syndrome in each group was calculated at maintenance phase baseline (randomization) and endpoint for evaluable patients using a last-observation-carried-forward (LOCF) approach. Metabolic syndrome was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. The study was conducted from March 2000 to June 2003 at 76 centers in Argentina, Mexico, and the United States. RESULTS At entry into the maintenance phase, 45/125 patients (36.0%) overall met criteria for metabolic syndrome. Mean changes in the 5 components of metabolic syndrome (waist circumference, triglyceride levels, high-density lipoprotein cholesterol level, blood pressure, and glucose level) from baseline to week 26 were small except for a meaningful reduction in triglycerides (placebo -18.9 mg/dL; aripiprazole -11.5 mg/dL). By the end of the maintenance phase (endpoint, LOCF), 5/18 placebo-treated patients (27.8%) and 4/14 aripiprazole-treated patients (28.6%) no longer met metabolic syndrome criteria. The proportion of patients with metabolic syndrome was similar in the placebo and aripiprazole groups at both baseline and week 26. There were no significant changes in any of the individual components of metabolic syndrome between aripiprazole- and placebo-treated patients during maintenance phase treatment. CONCLUSIONS The prevalence of metabolic syndrome in patients with bipolar disorder is higher than that commonly reported in the general population. The effect of 26 weeks of treatment with aripiprazole on the incidence of metabolic syndrome and its components was similar to placebo. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00036348.
Expression library immunization to discover and improve vaccine antigens

Summary: Genetic immunization is a novel method for vaccination in which DNA is delivered into the host to drive both cellular and humoral immune responses against its protein product. While genetic immunization can be potent, it requires that one have, in hand, a gene that encodes a protective protein antigen. Therefore, for many diseases, one cannot make a genetic vaccine because no protective antigen is known or no gene for this antigen is available. This lack of candidate antigens and their genes is a considerable bottleneck in developing new vaccines against old infectious agents, new emerging pathogens, and bioweapons. To address this limitation, we developed expression library immunization (ELI) as a high‐throughput technology to discover vaccine candidate genes at will, by using the immune system to screen the entire genome of a pathogen for vaccine candidate. To date, ELI has discovered new vaccine candidates from a diverse set of bacterial, fungal, and parasitic pathogens. In addition, the process of applying ELI to the genome of pathogens allows one to genetically re‐engineer these antigens to convert immunoevasive pathogen proteins into immunostimulatory vaccine antigens. Therefore, ELI is a potent technology to discover new vaccines and also generate genomic vaccines with amplified, multivalent immunostimulatory capacities.
Dissecting gamma frequency activity during human memory processing

Gamma frequency activity (30-150 Hz) is induced in cognitive tasks and is thought to reflect underlying neural processes. Gamma frequency activity can be recorded directly from the human brain using intracranial electrodes implanted in patients undergoing treatment for drug-resistant epilepsy. Previous studies have independently explored narrowband oscillations in the local field potential and broadband power increases. It is not clear, however, which processes contribute to human brain gamma frequency activity, or their dynamics and roles during memory processing. Here a large dataset of intracranial recordings obtained during encoding of words from 101 patients was used to detect, characterize and compare induced gamma frequency activity events. Individual bursts of gamma frequency activity were isolated in the time-frequency domain to determine their spectral features, including peak frequency, amplitude, frequency span, and duration. We found two distinct types of gamma frequency activity events that showed either narrowband or broadband frequency spans revealing characteristic spectral properties. Narrowband events, the predominant type, were induced by word presentations following an initial induction of broadband events, which were temporally separated and selectively correlated with evoked response potentials, suggesting that they reflect different neural activities and play different roles during memory encoding. The two gamma frequency activity types were differentially modulated during encoding of subsequently recalled and forgotten words. In conclusion, we found evidence for two distinct activity types induced in the gamma frequency range during cognitive processing. Separating these two gamma frequency activity components contributes to the current understanding of electrophysiological biomarkers, and may prove useful for emerging neurotechnologies targeting, mapping and modulating distinct neurophysiological processes in normal and epileptogenic brain.