Miracle-dz/UniFAR-FTUs huggingface dataset:
Aspects hydrogéologiques du Yucatan (Mexique)

Rasgos hidrogeologicos del Yucatan (Mexico). Los karsts sumergidos son numerosos e importantes en la peninsula del Yucatan (Mexico). Las exploraciones espeleonâuticas, los datos hidrologicos y fisico-quimicos de las cavidades litorales y submarinas han permitido comprender los principales rasgos hidrogeologicos de este tipo de karst. Este articulo trata del funcionamiento hidrogeologico de estos karsts litorales particulares, de la influencia de las mareas sobre las circu-laciones kârsticas, de la salinisacion de las aguas continentales y dela evalua-cion de las reservas de agua dulce. Igualmente, se propone una quantificacion de la ablacion kârstica. Estas distintas caracteristkas del karst de Yucatan se comparan con otros karsts litorales (Isla de Lifou y de Nullarbor). Palabras-claves : karst litoral, cavidades submarinas, cenotes, hidrogeologia, ablacion kârstica, Yucatan, Mexico.
Regulation of Melanosome Movement in the Cell Cycle by Reversible Association with Myosin V

Previously, we have shown that melanosomes of Xenopus laevis melanophores are transported along both microtubules and actin filaments in a coordinated manner, and that myosin V is bound to purified melanosomes (Rogers, S., and V.I. Gelfand. 1998. Curr. Biol. 8:161–164). In the present study, we have demonstrated that myosin V is the actin-based motor responsible for melanosome transport. To examine whether myosin V was regulated in a cell cycle-dependent manner, purified melanosomes were treated with interphase- or metaphase-arrested Xenopus egg extracts and assayed for in vitro motility along Nitella actin filaments. Motility of organelles treated with mitotic extract was found to decrease dramatically, as compared with untreated or interphase extract-treated melanosomes. This mitotic inhibition of motility correlated with the dissociation of myosin V from melanosomes, but the activity of soluble motor remained unaffected. Furthermore, we find that myosin V heavy chain is highly phosphorylated in metaphase extracts versus interphase extracts. We conclude that organelle transport by myosin V is controlled by a cell cycle-regulated association of this motor to organelles, and that this binding is likely regulated by phosphorylation of myosin V during mitosis.
Haemoglobin oxygen saturation is a determinant of cerebral artery blood flow velocity in children with sickle cell anaemia

Steady‐state haemoglobin (Hb) desaturation is a common finding in sickle cell anaemia (Hb SS) that could predispose to stroke by limiting oxygen delivery to the brain. To determine its association with the risk of overt stroke, we examined the relationship between daytime Hb saturation measured by pulse oximetry (SpO2) and cerebral artery blood flow velocity measured by transcranial Doppler ultrasonography (TCD), an established risk factor for overt stroke in Hb SS. We studied 181 children using multivariate models to control for known determinants of TCD velocity, including age, haematocrit, and a measure of stenosis. We found that SpO2 correlated significantly and inversely with TCD velocity in both the right and left middle cerebral arteries. Hb desaturation was associated with increased cerebral artery blood flow velocities and increased odds of abnormal TCD velocities, hence increased risk of stroke. About 5% of the variation in TCD velocity could be ascribed to Hb saturation while controlling for other determinants of TCD velocity. In conclusion, Hb saturation is a determinant of TCD velocity and a risk factor for stroke in children with Hb SS.
Time-Clustering-Based Place Prediction for Wireless Subscribers

Many of today's applications such as cellular network management, prediction and control of the spread of biological and mobile viruses, etc., depend on the modeling and prediction of human locations. However, having widespread wireless localization technology, such as pervasive cell-tower/GPS location estimation available for only the last few years, many factors that impact human mobility patterns remain underresearched. Furthermore, many industries including telecom providers are still in need of low-cost and simple location/place prediction methods that can be implemented on a large scale. In this paper, we focus on “temporal factors” and demonstrate that they significantly impact randomness, size, and probability distribution of people's movements. We also use this information to make simple and inexpensive prediction models for subscribers' visited places. We monitored individuals for a month and divided days and hours into segments for each user to obtain probability distribution of their places for each segment of time intervals and observed major improvement in future “time-based” predictions of their location compared to when temporal factors were not considered. In addition to quantifying the improvement in place prediction, we show that significant improvements can actually be achieved through an intuitive division of time intervals with no added computational complexity.
Expression of estrogen‐receptor related receptors in amphioxus and zebrafish: implications for the evolution of posterior brain segmentation at the invertebrate‐to‐vertebrate transition

Summary The evolutionary origin of vertebrate hindbrain segmentation is unclear since the amphioxus, the closest living invertebrate relative to the vertebrates, possesses a hindbrain homolog that displays no gross morphological segmentation. Three of the estrogen‐receptor related (ERR) receptors are segmentally expressed in the zebrafish hindbrain, suggesting that their common ancestor was expressed in a similar, reiterated manner. We have also cloned and determined the developmental expression of the single homolog of the vertebrate ERR genes in the amphioxus (AmphiERR). This gene is also expressed in a segmented manner in a region considered homologous to the vertebrate hindbrain. In contrast to the expression of amphioxus islet (a LIM‐homeobox gene that also labels motoneurons), AmphiERR expression persists longer in the hindbrain homolog and does not later extend to additional posterior cells. In addition, AmphiERR and one of its vertebrate homologs (ERRα) are expressed in the developing somitic musculature of amphioxus and zebrafish, respectively. Altogether, our results are consistent with fine structural evidence suggesting that the amphioxus hindbrain is segmented, and indicate that chordate ERR gene expression is a marker for both hindbrain and muscle segmentation. Furthermore, our data support an evolution model of chordate brain segmentation: originally, the program for anterior segmentation in the protochordate ancestors of the vertebrates resided in the developing axial mesoderm which imposed reiterated patterning on the adjacent neural tube; during early vertebrate evolution, this segmentation program was transferred to and controlled by the neural tube.
Generalizing Pooling Functions in Convolutional Neural Networks: Mixed, Gated, and Tree

We seek to improve deep neural networks by generalizing the pooling operations that play a central role in current architectures. We pursue a careful exploration of approaches to allow pooling to learn and to adapt to complex and variable patterns. The two primary directions lie in (1) learning a pooling function via (two strategies of) combining of max and average pooling, and (2) learning a pooling function in the form of a tree-structured fusion of pooling filters that are themselves learned. In our experiments every generalized pooling operation we explore improves performance when used in place of average or max pooling. We experimentally demonstrate that the proposed pooling operations provide a boost in invariance properties relative to conventional pooling and set the state of the art on several widely adopted benchmark datasets; they are also easy to implement, and can be applied within various deep neural network architectures. These benefits come with only a light increase in computational overhead during training and a very modest increase in the number of model parameters.
Comparing the strategies and outputs of designers using Algorithm of Inventive Problem Solving, Axiomatic Design, or Environment-Based Design

This paper presents the results of a study designed to compare the processes followed by practitioners of three design methods: the algorithm of inventive problem solving, axiomatic design, and environment-based design. Prior literature has postulated the complementary nature of these design methods, and in some cases, has provided case studies of their mutual application on a design problem. However, prior studies have not focused on the detailed activities used in each method to examine the similarities and differences in the outputs of the activities. In this study, a series of three one-day and three three-day design exercises were conducted simultaneously by three international research groups, each focusing on one method. The objectives of this study were to examine the early stages of the design process that deal with macro activities: problem analysis, problem synthesis, and design evaluation and decision making. Several micro design activities were conducted within these, depending on the design method: clarification of requirements, gathering information on existing technologies, initial conceptualization of an assembly of technologies, the identification of system contradictions/coupling, and the solution of contradictions. The objectives of this comparative study were to establish, from observations of practitioners --rather than from a theoretical point of view --the differences and complementarities between the design methods. The problems presented to designers covered a range of design tasks that spanned multiple disciplines, multiple levels of openendedness/specificity of the task, and various levels of inventiveness required. The comparison showed the complementary nature of the design methods, highlighted their respective strengths, and suggested the outlines of an integrated method based on the main benefit of each.
Joining Hands: Exploiting Monolingual Treebanks for Parsing of Code-mixing Data

In this paper, we propose efficient and less resource-intensive strategies for parsing of code-mixed data. These strategies are not constrained by in-domain annotations, rather they leverage pre-existing monolingual annotated resources for training. We show that these methods can produce significantly better results as compared to an informed baseline. Due to lack of an evaluation set for code-mixed structures, we also present a data set of 450 Hindi and English code-mixed tweets of Hindi multilingual speakers for evaluation.
Waking EEG Spectral Power and Coherence Differences Between High and Low Hypnotizable Subjects

Abstract EEG spectral power and coherence were analyzed under waking baseline condition in 19 high (HH) and 12 low (LH) hypnotizable subjects. In HH subjects, the theta1 and theta2 spectral power was higher than in LH. The major new finding of this study is that coherence between distributed brain regions was sharply elevated in HH subjects within the theta and alpha frequency bands. In contrast, spectral power and coherence of beta2 and gamma1 bands were higher in LH subjects as compared to HH subjects. However, the long distance coherence between frontal and posterior areas within beta-gamma frequency ranges was higher in HH subjects. It might be supposed that HH subjects are engaged in imaginal mental activity whereas LH ones are mainly engaged in linguistic activity. The neurophysiological basis of the obtained EEG differences is discussed.
ACL Reconstruction Preserving the ACL Remnant Achieves Good Clinical Outcomes and Can Reduce Subsequent Graft Rupture

Background: Although anterior cruciate ligament (ACL) reconstruction techniques that preserve remnant tissues have been described, complete preservation may be difficult, with little known about its clinical advantages. Purpose: To compare clinical outcomes in patients undergoing ACL reconstruction with and without ACL remnant preservation. Study Design: Case-control study. Methods: Of 372 patients who underwent surgical treatment of an ACL injury between September 2006 and July 2010, 154 had no remaining identifiable ligament tissue and were excluded from this study. Attempts were made to preserve the ACL remnant as much as possible in the remaining 218 patients. These patients were divided into 2 groups: those in whom the remnant was preserved (group 1, n = 85) and those in whom the remnant was not preserved (group 2, n = 98). Patients were followed for at least 24 months. Outcomes, including graft rupture, were compared in the 2 groups. Results: Time from injury to surgery was significantly shorter (7.3 ± 16.3 vs 16.0 ± 30.3 months; P < .05) and the preinjury Tegner activity was significantly higher (7.6 ± 1.4 vs 7.1 ± 1.2; P < .05; 95% confidence interval, 1.2-13.7) in group 1 than in group 2. The postoperative negative ratio of the pivot-shift test was similar in the 2 groups (87% vs 81%). Anterior stability of the knee, as measured by a KT-2000 arthrometer, was significantly better in group 1 than in group 2 (1.0 ± 0.8 vs 1.3 ± 1.0 mm; P < .05). ACL graft rupture occurred in 1 patient (1.1%) in group 1 and in 7 patients (7.1%) in group 2 (P < .05). Regression analysis showed that preservation of the remnant decreased the likelihood of graft rupture (odds ratio, 11.2; 95% confidence interval, 1.2-101.7). Conclusion: These findings confirmed that preserving the remnant tissue of the ACL may facilitate recovery of function and decrease graft rupture after primary reconstruction.
Exploring neonicotinoid effects on Drosophila: insights into olfactory memory, neurotransmission, and synaptic connectivity

Neonicotinoid insecticides, the fastest-growing class in recent decades, interfere with cholinergic neurotransmission by binding to the nicotinic acetylcholine receptor. This disruption affects both targeted and non-targeted insects, impairing cognitive functions such as olfaction and related behaviors, with a particular emphasis on olfactory memory due to its ecological impact. Despite the persistent presence of these chemicals in the environment, significant research gaps remain in understanding the intricate interplay between cognitive function, development, neuronal activity, and neonicotinoid-induced toxicity. This study focuses on the fruit fly Drosophila melanogaster, chosen for its genetic tractability, well-characterized neural circuitry, and remarkable parallels with bees in neurotransmitter systems and brain structures. Our aim is to establish the fruit fly as a valuable model organism for studying the effects of neonicotinoids on behavior and neuronal circuitry, with particular attention to olfactory memory and associated brain circuitries. To achieve this aim, we conducted experiments to investigate the effects of short-term exposure to sublethal doses of the neonicotinoid imidacloprid, mimicking realistic environmental insecticide exposure, on the formation of odor memories. Additionally, we evaluated synaptic contacts and cholinergic neurotransmission within the mushroom body, the primary memory network of insects. Our results showed significant impairments in odor memory formation in flies exposed to imidacloprid, with exposure during the adult stage showing more pronounced effects than exposure during the larval stage. Additionally, functional studies revealed a decrease in synaptic contacts within the intrinsic olfactory projection neurons and the mushroom body. Furthermore, another experiment showed an odor-dependent reduction in cholinergic neurotransmission within this network. In summary, employing Drosophila as a model organism provides a robust framework for investigating neonicotinoid effects and understanding their diverse impacts on insect physiology and behavior. Our study initiates the establishment of the fruit fly as a pivotal model for exploring neonicotinoid influences, shedding light on their effects on olfactory memory, neuronal integrity, and synaptic transmission.
Seroprevalence Survey of American Trypanosomiasis in Central Valley of Toluca

American trypanosomiasis is a growing health issue in the Americas. México is an endemic country, where some locations such as in the State of México are considered highly prevalent. In the valley of Toluca city, the capital of the State of Mexico, there exists an apparent high prevalence in dogs. The absence of triatomine vectors suggests that dogs may not be infected. Therefore, we conducted a directed survey to domiciliated and nondomiciliated dogs to reassess dogs' T. cruzi seroprevalence status. HAI and ELISA serologic tests were applied to 124 and 167 serums of domiciliated and nondomiciliated dogs in the target city. Risk factors were estimated, but the results did not show any evidence to assess them. No domiciliated dogs tested positive to both tests, whereas only one non-domiciliated dog resulted positive. This animal may have acquired the infection in an endemic area and then migrated to Toluca. Research results indicate that T. cruzi infection is not actively transmitted among dogs, and it is pointed out that dogs are the main sentinel animal population to evaluate a possible expansion of the territory affected by Chagas' disease.
Normal Forms and Tensor Ranks of Pure States of Four Qubits

We examine the SLOCC classification of the (non-normalized) pure states of four qubits obtained by F. Verstraete et al. The rigorous proofs of their basic results are provided and necessary corrections implemented. We use Invariant Theory to solve the problem of equivalence of pure states under SLOCC transformations of determinant 1 and qubit permutations. As a byproduct, we produce a new set of generators for the invariants of the Weyl group of type F_4. We complete the determination of the tensor ranks of 4-qubit pure states initiated by J.-L. Brylinski. As a result we obtain a simple algorithm for computing these ranks. We obtain also a very simple classification of pure states of rank at most 3.
Incidence of Neonatal Birth Injuries and Related Factors in Kashan, Iran

Background: Birth injuries are defined as the impairment of neonatal body function due to adverse events that occur at birth and can be avoidable or inevitable. Despite exact prenatal care, birth trauma usually occurs, particularly in long and difficult labor or fetal malpresentations. Objectives: This study aimed to investigate the incidence of birth injuries and their related factors in Kashan, Iran, during 2012-2013. Patients and Methods: In this cross-sectional study, all live-born neonates in the hospitals of Kashan City were assessed prospectively by a checklist included demographic variables (maternal age, weight, and nationality), reproductive and labor variables (prenatal care, parity, gestational age, premature rupture of membrane (PROM), fetal heart rate (FHR) pattern, duration of PROM, induction of labor, fundal pressure, shoulder dystocia, fetal presentation, duration of second stage, type of delivery, and delivery attendance), and neonatal variables (sex, birth weight, height, head circumference, Apgar score, and neonatal trauma). Birth trauma was diagnosed based on pediatrician or resident examination and in some cases confirmed by paraclinic methods. Statistical analyses were performed by chi-square, student’s t-test, and multiple logistic regression analyses using SPSS version 17. P ≤ 0.05 was considered statistically significant. Results: In this study, the incidence of birth trauma was 2.2%. Incidence of trauma was 3.6% in vaginal deliveries and 1.2% in cesarean sections (P < 0.0001). The most common trauma was cephalohematoma (57.2%) and then asphyxia (16.8%). In multiple logistic regression analyses, decreased fetal heart rate (FHR), fundal pressure, shoulder dystocia, vaginal delivery, male sex, neonatal weight, delivery by resident, induction of labor, and delivery in a teaching hospital were predictors of birth trauma. Conclusions: Overall, incidence of birth trauma in Kashan City was lower in comparison with most studies. Considering existing risk factors, further monitoring on labor, and delivery management in teaching hospitals are recommended to prevent birth injuries. In addition, careful supervision on students and residents' training should be applied in teaching hospitals.
Identification and decentralized adaptive control using dynamical neural networks with application to robotic manipulators

Efficient implementation of a neural network-based strategy for the online adaptive control of complex dynamical systems characterized by an interconnection of several subsystems (possibly nonlinear) centers on the rapidity of the convergence of the training scheme used for learning the system dynamics. For illustration, in order to achieve a satisfactory control of a multijointed robotic manipulator during the execution of high speed trajectory tracking tasks, the highly nonlinear and coupled dynamics together with the variations in the parameters necessitate a fast updating of the control actions. For facilitating this requirement, a multilayer neural network structure that includes dynamical nodes in the hidden layer is proposed, and a supervised learning scheme that employs a simple distributed updating rule is used for the online identification and decentralized adaptive control. Important characteristic features of the resulting control scheme are discussed and a quantitative evaluation of its performance in the above illustrative example is given.
iNOS‐dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis

Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas. MFH has been proposed to be a lesion accompanied with inflammatory responses. During chronic inflammation, reactive nitrogen and oxygen species generated from inflammatory cells are considered to participate in carcinogenesis by causing DNA damage. 8‐nitroguanine is a mutagenic nitrative DNA lesion formed during chronic inflammation. We examined whether nitrative DNA damage is related to the prognosis of MFH patients. We performed immunohistochemical analyses to examine the distribution of DNA damage and the expression of inflammation‐related molecules including inducible nitric oxide synthase (iNOS), nuclear factor‐κB (NF‐κB), and cyclooxygenase‐2 (COX‐2) in clinical specimens from 25 patients with MFH. We also analyzed the correlation of DNA damage or the expression of these genes with the prognosis of MFH patients. Immunohistochemical staining revealed that the formation of 8‐nitroguanine and 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine (8‐oxodG), an oxidative DNA lesion, occurred to a much greater extent in MFH tissue specimens from deceased patients than in live patients. iNOS, NF‐κB and COX‐2 were colocalized with 8‐nitroguanine in MFH tissues. It is noteworthy that the statistical analysis using the Kaplan‐Meier method demonstrated strong 8‐nitroguanine staining to be associated with a poor prognosis. In conclusion, 8‐nitroguanine appears to participate in not only the initiation and promotion of MFH, but also in the progression of MFH, and could therefore be used as a promising biomarker to evaluate the prognosis of cancer patients. (Cancer Sci 2007; 98: 163–168)