Miracle-dz/UniFAR-FTUs huggingface dataset:
Security implications of electronic commerce: a survey of consumers and businesses

Examines the general requirement for security technologies in order to provide a basis for trust in the e‐commerce environment. The discussion is supported by the findings from two surveys, conducted by the authors, among general Internet users (i.e. potential target consumers) and commercial businesses. These surveys considered both the attitudes to e‐commerce in general and opinions relating to the associated security requirements. Attempts were also made to assess the respondent’s knowledge of the existing security safeguards that may be applied. The survey results suggest that, while there is significant concern among Internet‐based consumers regarding the security of their purchasing activities, these are outweighed by the merits offered by the medium. The results also suggested a lack of awareness or understanding of the security technologies that are available and it is concluded that overcoming this problem would help to establish a wider foundation of trust in the new technology.
Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors

Background Peptidylarginine deiminase (PAD) catalyzes the conversion of arginine residues to citrulline residues, termed citrullination. Recent studies have suggested that PAD isoform 2 (PADI2) plays an important role in tumors, although its tumorigenic effect and mechanism are largely unknown. Materials and methods Immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) were used to investigate the expression level of PADI2 in various tumor tissues and patient blood samples, respectively. MNK-45 and Bel-7402 tumor cell lines originating from gastric and liver tumors, respectively, were treated with anti-PADI2 siRNA, and the subsequent cell proliferation, apoptosis and migration were observed. Polymerase chain reaction (PCR) arrays, including Cancer PathwayFinder, Oncogenes and Tumor Suppressor Genes, p53 Signaling Pathway, Signal Transduction Pathway and Tumor Metastasis PCR arrays, were used to investigate the tumorigenic pathway of PADI2 in the siRNA-treated tumor cells. This analysis was verified by real-time PCR. Results Immunohistochemistry detected significantly increased expression of PADI2 in invasive breast ductal carcinoma, cervical squamous cell carcinoma, colon adenocarcinoma, liver hepatocellular carcinoma, lung cancer, ovarian serous papillary adenocarcinoma and papillary thyroid carcinoma samples. ELISA detected a twofold increase in PADI2 expression in the blood of 48.3% of patients with liver cancer, 38% of patients with cervical carcinoma and 32% of patients with gastric carcinoma. Increased apoptosis and decreased cell proliferation and migration were observed in the anti-PADI2 siRNA-treated MNK-45 cells, and increased cell proliferation and migration and decreased apoptosis were observed in the treated Bel-7402 cells with suppressed PADI2 expression. PCR arrays and real-time PCR detected significantly decreased CXCR2 and EPO expression in the MNK-45 cells and Bel-7402 cells, respectively, with the anti-PADI2 siRNA treatments. Conclusion PADI2 expression is increased in many types of tumor tissues and patient blood samples. PADI2 may advance abnormal cell behavior in gastric cancers by mediating CXCR2, a well-known gene that stimulates cell proliferation and invasion. However, PADI2 might have deleterious effects on tumor growth and metastasis in liver tumor cells by regulating the expression of EPO, a gene with controversial functions in tumor growth. The results suggest that the effect of PADI2 on tumorigenesis is multifactorial, depending on the tumor type.
Maternal caffeine intake during pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study

Objectives To study the association between maternal caffeine intake during pregnancy and the child’s weight gain and overweight risk up to 8 years. Design Prospective nationwide pregnancy cohort. Setting The Norwegian Mother and Child Cohort Study. Participants A total of 50 943 mothers recruited from 2002 to 2008 and their children, after singleton pregnancies, with information about average caffeine intake assessed at mid-pregnancy. Outcome measure Child’s body size information at 11 age points from 6 weeks to 8 years. We defined excess growth in infancy as a WHO weight gain z-score of >0.67 from birth to age 1 year, and overweight according to the International Obesity Task Force. We used a growth model to assess individual growth trajectories. Results Compared with pregnant women with low caffeine intake (<50 mg/day, 46%), women with average (50–199 mg/day, 44%), high (≥200–299 mg/day, 7%) and very high (≥300 mg/day, 3%) caffeine intakes had an increased risk of their child experiencing excess growth in infancy, after adjustment for confounders (OR=1.15, 95% CI 1.09 to 1.22, OR=1.30, 95% CI 1.16 to 1.45, OR=1.66, 95% CI 1.42 to 1.93, respectively). In utero exposure to any caffeine was associated with higher risk of overweight at age 3 years and 5 years, while the association persisted at 8 years, only for very high exposures. Any caffeine intake was associated with increased body mass index from infancy to childhood. Children prenatally exposed to caffeine intake >200 mg/day had consistently higher weight. Very high caffeine exposures were associated with higher weight gain velocity from infancy to age 8 years. Conclusion Any caffeine consumption during pregnancy is associated with a higher risk of excess infant growth and of childhood overweight, mainly at preschool ages. Maternal caffeine intake may modify the overall weight growth trajectory of the child from birth to 8 years. This study adds supporting evidence for the current advice to reduce caffeine intake during pregnancy.
Risk analysis and Black Swans: two strategies for de-blackening

With his book The Black Swan: The Impact of the Highly Improbable, Nassim N. Taleb brought the Black Swan metaphor to the center of risk analysis debates. His main thesis is that the course of the world is determined by the sudden coming of a small number of high impact events whose occurrences are detectable only through hindsight. When relying on prediction, risk analysis is doomed to fail. The standard route of refutation and rehabilitation of predictive practices has been to oppose Taleb’s worldview. In this article, we develop an alternative route of refutation in which we separate Taleb’s claim of unpredictability from his worldview. Moreover, in our justification of the possibilities of predicting in a Black Swan world, we favor an extension of the Black Swan domain so that it includes unknown knowns in addition to unknown unknowns. The article advocates for a bridging of perspectives in which predicting not only involves the sphere of knowledge, but also the sphere of imagination, bringing the risk communication to the fore. Related to the analysis of extraordinary high-impact events, the merits of an imaginative perspective on prediction is illustrated by the terrorist attacks in Norway on July 22 2011, and some key challenges for further developing such a perspective within risk analysis are sketched.
Acute effects of calcium supplements on blood pressure and blood coagulation: secondary analysis of a randomised controlled trial in post-menopausal women

Abstract Recent evidence suggests that Ca supplements increase the risk of cardiovascular events, but the mechanism(s) by which this occurs is uncertain. In a study primarily assessing the effects of various Ca supplements on blood Ca levels, we also investigated the effects of Ca supplements on blood pressure and their acute effects on blood coagulation. We randomised 100 post-menopausal women to 1 g/d of Ca or a placebo containing no Ca. Blood pressure was measured at baseline and every 2 h up to 8 h after their first dose and after 3 months of supplementation. Blood coagulation was measured by thromboelastography (TEG) in a subgroup of participants (n 40) up to 8 h only. Blood pressure declined over 8 h in both the groups, consistent with its normal diurnal rhythm. The reduction in systolic blood pressure was smaller in the Ca group compared with the control group by >5 mmHg between 2 and 6 h (P≤0·02), and the reduction in diastolic blood pressure was smaller at 2 h (between-groups difference 4·5 mmHg, P=0·004). Blood coagulability, assessed by TEG, increased from baseline over 8 h in the calcium citrate and control groups. At 4 h, the increase in the coagulation index was greater in the calcium citrate group compared with the control group (P=0·03), which appeared to be due to a greater reduction in the time to clot initiation. These data suggest that Ca supplements may acutely influence blood pressure and blood coagulation. Further investigation of this possibility is required.
Fast View Synthesis with Deep Stereo Vision

Novel view synthesis is an important problem in computer vision and graphics. Over the years a large number of solutions have been put forward to solve the problem. However, the large-baseline novel view synthesis problem is far from being "solved". Recent works have attempted to use Convolutional Neural Networks (CNNs) to solve view synthesis tasks. Due to the difficulty of learning scene geometry and interpreting camera motion, CNNs are often unable to generate realistic novel views. In this paper, we present a novel view synthesis approach based on stereo-vision and CNNs that decomposes the problem into two sub-tasks: view dependent geometry estimation and texture inpainting. Both tasks are structured prediction problems that could be effectively learned with CNNs. Experiments on the KITTI Odometry dataset show that our approach is more accurate and significantly faster than the current state-of-the-art. The code and supplementary material will be publicly available. Results could be found here this https URL
Effect of Environmental Enrichment on the Behavior and Welfare of Japanese Broilers at a Commercial Farm

The effect of hay bales and perches as environmental enrichment material was investigated on the behavior, heterophil/lymphocyte (H/L) ratio, footpad dermatitis (FPD), and productivity of Japanese broilers in a commercial farm. About 21,500 birds were allocated to 4 houses: male versus female×control versus treatment house. We observed maintenance behavior, the utilization of hay bales and perches, and the H/L ratio of birds at 3, 5, and 8 weeks of age. FPD was scored and productivity was calculated at about 60 days after hatching. Compared to birds in the control houses, birds in the treatment houses invested more time in stand-resting and moving behaviors (P<0.01, for each behavior) and less time feeding, drinking, and sit-resting (P<0.01, for each behavior). Females used the hay bales and perches more than the males (P<0.1 and P<0.01, respectively). The activity and utilization of hay bales and perches decreased with age (P<0.01, for each behavior, respectively). The H/L ratio of birds in the treatment houses was lower than that in the control houses (P<0.01). The prevalence of FPD was milder in the treatment houses compared to the control houses for females (P<0.01), but not for males. In conclusion, hay bales and perches represent effective enrichment materials, allowing broilers to express normal behavior, alleviating stress in the younger and lighter birds of both sexes, and reducing FPD in female birds using the hay bales and perches more than males.
Effects of hydrogen peroxide on diazepam and xylazine sedation in chicks

ABSTRACT Oxidative stress may cause various neuronal dysfunctions and modulate responses to many centrally acting drugs. This study examines the effects of oxidative stress produced by hydrogen peroxide (H2O2) on sedation induced by diazepam or xylazine as assessed in 7-14 day-old chicks. Day-old chicks were provided with either plane tap water (control group) or H2O2 in tap water as 0.5% v/v drinking solution for two weeks in order to produce oxidative stress. Spectrophotometric methods were used to determine glutathione and malondialdehyde concentrations in plasma and whole brain. Drug-induced sedation in the chicks was assessed by monitoring the occurrence of signs of sedation manifested as drooping of the head, closed eyelids, reduced motility or immotility, decreased distress calls, and recumbency. The latency to onset of sedation and its duration were also recorded. H2O2 treatment for two weeks significantly decreased glutathione and increased malondialdehyde concentrations in plasma and whole brain of the chicks on days 7, 10 and 14 as compared with respective age-matched control groups. H2O2 decreased the median effective doses of diazepam and xylazine for the induction of sedation in chicks by 46% and 63%, respectively. Injection of diazepam at 2.5, 5 and 10 mg/kg, i.m. or xylazine at 2, 4 and 8 mg/kg, i.m. induced sedation in both control and H2O2-treated chicks in a dose dependent manner, manifested by the above given signs of sedation. H2O2 significantly decreased the latency to onset of sedation in chicks treated with diazepam at 5 and 10 mg/kg, increased the duration of sedation and prolonged the total recovery time in comparison with respective non-stressed control chicks. A similar trend occurred with xylazine in the H2O2-treated chicks, though the differences from control counterparts did not attain the statistical significance, except for the recovery time of the lowest dose of the drug. The data suggest that H2O2-induced oxidative stress sensitizes the chicks to the depressant action of the sedatives diazepam and xylazine. Further studies are needed to examine the potential role of oxidative stress in modulating the actions of therapeutic agents on the brain.
The Rise of Exporting by U.S. Firms

Although a great deal of ink has been spilled over the consequences of globalization, we do not yet fully understand the causes of increased worldwide trade. Using confidential microdata from the U.S. Census, we document widespread entry into countries abroad by U.S. firms from 1987 to 2006. We show that this extensive margin growth is unlikely to have been due to significant declines in entry costs. We instead find evidence of large roles for the development of the internet, trade agreements, and foreign income growth in driving these trends.
Asset Market Participation, Monetary Policy Rules, and the Great Inflation

Abstract This paper argues that limited asset market participation is crucial in explaining U.S. macroeconomic performance and monetary policy before the 1980s and their changes thereafter. In an otherwise conventional sticky-price model, standard aggregate demand logic is inverted at low enough asset market participation: interest rate increases become expansionary, and passive monetary policy ensures equilibrium determinacy and maximizes welfare. This suggests that Federal Reserve policy in the pre-Volcker era was better than conventional wisdom implies. We provide empirical evidence consistent with this hypothesis and study the relative merits of changes in structure and shocks for reproducing the conquest of the Great Inflation and the Great Moderation.
Attentional dysfunction and recovery in concussion: effects on the P300m and contingent magnetic variation

ABSTRACT Primary objective: To examine the effect of concussion on indices of attention using magnetoencephalography. Methods and procedures: Thirteen patients were recruited from the emergency department and scanned within 3–6 days of injury. Five returned for follow-up scans one and three months post-injury. Thirteen healthy controls also completed testing. During MEG acquisition, participants performed the Attention Network Test (ANT). Cognitive evoked responses to this task include a cue-evoked P300m, a contingent magnetic variation (CMV) and a target-evoked P300m. The Rivermead Postconcussion Symptom Questionnaire and Sport Concussion Assessment Tool (SCAT3) were administered in all sessions. Results: Patients suffering from concussion had slower response times and benefitted more from spatial cues than did controls. Global activation for all three evoked responses was lower for patients than controls. In a small sample of patients who returned for follow-up, the CMV and target P300m improved with recovery. Conclusions: MEG-evoked responses to the ANT reveal neurophysiological evidence of attentional dysfunction within days of injury. A pattern of improvement was also observed over the course of three months for the P300m, while behavioural performance did not change significantly. Further development of this method may yield a useful adjunct to neurological examination for concussion diagnosis and monitoring.
‘ New insights into the molecular regulation of trace element metabolism ’ Intestinal and placental zinc transport pathways

Mammalian members of the cation diffusion facilitator (CDF) and zrt-, irt-like protein (ZIP) families of Zn transporters, initially identified in Saccharomyces cerevisiae and Arabidopsis thalania, have been cloned during the last 8 years and have been classified as families SLC30 and SLC39 respectively. The cloning of human Zn transporters ZnT-like transporter 1 (hZTL1)/ZnT5 (SLC30A5) and hZIP4 (SLC39A4) were major advances in the understanding of the molecular mechanisms of dietary Zn absorption. Both transporters are localised at the enterocyte apical membrane and are, therefore, potentially of fundamental importance in dietary Zn uptake. hZTL1 mediates Zn uptake when expressed in Xenopus laevis oocytes and hZIP4 is mutated in most cases of the inherited Zn deficiency disease acrodermatitis enteropathica. Localisation of hZTL1/ZnT5 at the apical membrane of the placental syncytiotrophoblast indicates a fundamental role in the transfer of Zn to the foetus. Observations in rodent models indicate that in the intestine increased Zn availability increases expression of Slc30 Zn transporters. Human intestinal Caco-2 cells show a similar response to increasing the Zn concentration of the nutrient medium in relation to the expression of mRNA corresponding to several Zn transporters and that of ZnT1 (SLC30A1) and hZTL1/ZnT5 proteins. In the human placental cell line JAR, however, expression at the mRNA level of a number of Zn transporters is not modified by Zn availability, whilst ZnT1 and hZTL1/ZnT5 proteins are reduced under Zn-supplemented conditions. These differences between Caco-2 and JAR cells in Zn transporter gene responses to Zn supply may reflect the different extracellular Zn concentrations encountered by the corresponding cell types in vitro.
Take It or Leave It

This study employs a cross-sectional design to explore sociology majors’ attitudes toward research methods. Survey data from a convenience sample of students enrolled in 16 departments are used to compare the attitudes of students who have and have not completed a research methods course. Despite consistent anecdotal claims that students harbor disdain or anxiety about research methods, the results indicate that students’ attitudes are lukewarm, at worst. Completion of a research methods course is associated with more positive affect toward research methods and feelings of greater cognitive competence in research methods knowledge and skills. The results also indicate that completion of a research methods course is not associated with being more interested in research methods or feeling the subject is less difficult.
Analyzing and Characterizing User Intent in Information-seeking Conversations

Understanding and characterizing how people interact in information-seeking conversations is crucial in developing conversational search systems. In this paper, we introduce a new dataset designed for this purpose and use it to analyze information-seeking conversations by user intent distribution, co-occurrence, and flow patterns. The MSDialog dataset is a labeled dialog dataset of question answering (QA) interactions between information seekers and providers from an online forum on Microsoft products. The dataset contains more than 2,000 multi-turn QA dialogs with 10,000 utterances that are annotated with user intent on the utterance level. Annotations were done using crowdsourcing. With MSDialog, we find some highly recurring patterns in user intent during an information-seeking process. They could be useful for designing conversational search systems. We will make our dataset freely available to encourage exploration of information-seeking conversation models.
Mediators and moderators of long-term effects of violent video games on aggressive behavior: practice, thinking, and action.

IMPORTANCE Although several longitudinal studies have demonstrated an effect of violent video game play on later aggressive behavior, little is known about the psychological mediators and moderators of the effect. OBJECTIVE To determine whether cognitive and/or emotional variables mediate the effect of violent video game play on aggression and whether the effect is moderated by age, sex, prior aggressiveness, or parental monitoring. DESIGN, SETTING, AND PARTICIPANTS Three-year longitudinal panel study. A total of 3034 children and adolescents from 6 primary and 6 secondary schools in Singapore (73% male) were surveyed annually. Children were eligible for inclusion if they attended one of the 12 selected schools, 3 of which were boys' schools. At the beginning of the study, participants were in third, fourth, seventh, and eighth grades, with a mean (SD) age of 11.2 (2.1) years (range, 8-17 years). Study participation was 99% in year 1. MAIN OUTCOMES AND MEASURES The final outcome measure was aggressive behavior, with aggressive cognitions (normative beliefs about aggression, hostile attribution bias, aggressive fantasizing) and empathy as potential mediators. RESULTS Longitudinal latent growth curve modeling demonstrated that the effects of violent video game play are mediated primarily by aggressive cognitions. This effect is not moderated by sex, prior aggressiveness, or parental monitoring and is only slightly moderated by age, as younger children had a larger increase in initial aggressive cognition related to initial violent game play at the beginning of the study than older children. Model fit was excellent for all models. CONCLUSIONS AND RELEVANCE Given that more than 90% of youths play video games, understanding the psychological mechanisms by which they can influence behaviors is important for parents and pediatricians and for designing interventions to enhance or mitigate the effects.