Miracle-dz/UniFAR-FTUs huggingface dataset:
Selective disruption of the recognition of facial expressions of anger

Appetitive aggression occurs in the context of resource/dominance disputes in a wide variety of species. Hence, the possibility arises that a specific neural system may have evolved to detect and coordinate responses to this specific form of challenge or threat. The dopamine system has been implicated in the processing of signals of aggression in social-agonistic encounters in several species. Here we report that dopaminergic antagonism in healthy male volunteers, following acute administration of the dopamine D2-class receptor antagonist sulpiride, leads to a selective disruption in the recognition of facial expressions of anger (signals of appetitive aggression in humans), but leaves intact recognition of other emotions and the matching of unfamiliar faces.
A comparative study of microbial diversity and community structure in marine sediments using poly(A) tailing and reverse transcription-PCR

To obtain a better understanding of metabolically active microbial communities, we tested a molecular ecological approach using poly(A) tailing of environmental 16S rRNA, followed by full-length complementary DNA (cDNA) synthesis and sequencing to eliminate potential biases caused by mismatching of polymerase chain reaction (PCR) primer sequences. The RNA pool tested was extracted from marine sediments of the Yonaguni Knoll IV hydrothermal field in the southern Okinawa Trough. The sequences obtained using the poly(A) tailing method were compared statistically and phylogenetically with those obtained using conventional reverse transcription-PCR (RT-PCR) with published domain-specific primers. Both methods indicated that Deltaproteobacteria are predominant in sediment (>85% of the total sequence read). The poly(A) tailing method indicated that Desulfobacterales were the predominant Deltaproteobacteria, while most of the sequences in libraries constructed using RT-PCR were derived from Desulfuromonadales. This discrepancy may have been due to low coverage of Desulfobacterales by the primers used. A comparison of library diversity indices indicated that the poly(A) tailing method retrieves more phylogenetically diverse sequences from the environment. The four archaeal 16S rRNA sequences that were obtained using the poly(A) tailing method formed deeply branching lineages that were related to Candidatus “Parvarchaeum” and the ancient archaeal group. These results clearly demonstrate that poly(A) tailing followed by cDNA sequencing is a powerful and less biased molecular ecological approach for the study of metabolically active microbial communities.
Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

SUMMARY Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to therapy. We first discovered that abnormal myelin hypercitrullination, even in normal-appearing white matter, by peptidylarginine deiminases (PADs) correlates strongly with disease severity and might have an important role in MS progression. Hypercitrullination is known to promote focal demyelination through reduced myelin compaction. Here we report that 2-chloroacetamidine (2CA), a small-molecule, PAD active-site inhibitor, dramatically attenuates disease at any stage in independent neurodegenerative as well as autoimmune MS mouse models. 2CA reduced PAD activity and protein citrullination to pre-disease status. In the autoimmune models, disease induction uniformly induced spontaneous hypercitrullination with citrulline+ epitopes targeted frequently. 2CA rapidly suppressed T cell autoreactivity, clearing brain and spinal cord infiltrates, through selective removal of newly activated T cells. 2CA essentially prevented disease when administered before disease onset or before autoimmune induction, making hypercitrullination, and specifically PAD enzymes, a therapeutic target in MS models and thus possibly in MS.
Three‐dimensional FEM derived elastic Green's functions for the coseismic deformation of the 2005 Mw 8.7 Nias‐Simeulue, Sumatra earthquake

Using finite element models (FEMs), we examine the sensitivity of surface displacements to the location of fault slip, topography, and three‐dimensional variations in elastic moduli in the context of a 2‐D infinite thrust fault. We then evaluate the impact of these factors and fault geometry on surface displacements and estimates of the distribution of coseismic slip associated with the 2005 Mw 8.7 Nias‐Simeulue, Sumatra earthquake. Topographic effects can be significant near the trench, where bathymetric gradients are highest and the fault is closest to the free surface. Variations in Young's modulus can significantly alter predicted deformation. Surface displacements are relatively insensitive to perturbations in Poisson's ratio for shear sources, but may play a stronger role when the source has a dilatational component. If we generate synthetic displacements using a heterogeneous elastic model and then use an elastic half‐space or layered earth model to estimate the slip distribution and fault geometry, we find systematic residuals of surface displacements and different slip patterns compared to the input fault slip model. The coseismic slip distributions of the 2005 earthquake derived from the same fault geometry and different material models show that the rupture areas are narrower in all tested heterogeneous elastic models compared to that obtained using half‐space models. This difference can be understood by the tendency to infer additional sources in elastic half‐space models to account for effects that are intrinsically due to the presence of rheological gradients. Although the fit to surface observations in our preferred 3‐D FEM model is similar to that from a simple half‐space model, the resulting slip distribution may be a more accurate reflection the true fault slip behavior.
Extreme temperature events alter demographic rates, relative fitness, and community structure

The frequency and magnitude of extreme events are predicted to increase under future climate change. Despite recent advancements, we still lack a detailed understanding of how changes in the frequency and amplitude of extreme climate events are linked to the temporal and spatial structure of natural communities. To answer this question, we used a combination of laboratory experiments, field experiments, and analysis of multi‐year field observations to reveal the effects of extreme high temperature events on the demographic rates and relative dominance of three co‐occurrence aphid species which differ in their transmission efficiency of different agricultural pathogens. We then linked the geographical shift in their relative dominance to frequent extreme high temperatures through a meta‐analysis. We found that both frequency and amplitude of extreme high temperatures altered demographic rates of species. However, these effects were species‐specific. Increasing the frequency and amplitude of extreme temperature events altered which species had the highest fitness. Importantly, this change in relative fitness of species was consistent with significant changes in the relative dominance of species in natural communities in a 1 year long field heating experiment and 6 year long field survey of natural populations. Finally, at a global spatial scale, we found the same relationship between relative abundance of species and frequency of extreme temperatures. Together, our results indicate that changes in frequency and amplitude of extreme high temperatures can alter the temporal and spatial structure of natural communities, and that these changes are driven by asymmetric effects of high temperatures on the demographic rates and fitness of species. They also highlight the importance of understanding how extreme events affect the life‐history of species for predicting the impacts of climate change at the individual and community level, and emphasize the importance of using a broad range of approaches when studying climate change.
Gender-related effects of prefrontal cortex connectivity: a resting-state functional optical tomography study

The prefrontal cortex (PFC) is thought to play an important role in “higher” brain functions such as personality and emotion that may associated with several gender-related mental disorders. In this study, the gender effects of functional connectivity, cortical lateralization and significantly differences in the PFC were investigated by using resting-state functional optical tomography (fOT) measurement. A total of forty subjects including twenty healthy male and twenty healthy female adults were recruited for this study. In the results, the hemoglobin responses are higher in the male group. Additionally, male group exhibited the stronger connectivity in the PFC regions. In the result of lateralization, leftward dominant was observed in the male group but bilateral dominance in the female group. Finally, the 11 channels of the inferior PFC regions (corresponding to the region of Brodmann area 45) are significant different with spectrum analysis. Our findings suggest that the resting-state fOT method can provide high potential to apply to clinical neuroscience for several gender-related mental disorders diagnosis.
Default Mode Network in the Effects of Δ9-Tetrahydrocannabinol (THC) on Human Executive Function

Evidence is increasing for involvement of the endocannabinoid system in cognitive functions including attention and executive function, as well as in psychiatric disorders characterized by cognitive deficits, such as schizophrenia. Executive function appears to be associated with both modulation of active networks and inhibition of activity in the default mode network. In the present study, we examined the role of the endocannabinoid system in executive function, focusing on both the associated brain network and the default mode network. A pharmacological functional magnetic resonance imaging (fMRI) study was conducted with a placebo-controlled, cross-over design, investigating effects of the endocannabinoid agonist Δ9-tetrahydrocannabinol (THC) on executive function in 20 healthy volunteers, using a continuous performance task with identical pairs. Task performance was impaired after THC administration, reflected in both an increase in false alarms and a reduction in detected targets. This was associated with reduced deactivation in a set of brain regions linked to the default mode network, including posterior cingulate cortex and angular gyrus. Less deactivation was significantly correlated with lower performance after THC. Regions that were activated by the continuous performance task, notably bilateral prefrontal and parietal cortex, did not show effects of THC. These findings suggest an important role for the endocannabinoid system in both default mode modulation and executive function. This may be relevant for psychiatric disorders associated with executive function deficits, such as schizophrenia and ADHD.
Propagation of centromeric chromatin requires exit from mitosis

Centromeres direct chromosomal inheritance by nucleating assembly of the kinetochore, a large multiprotein complex required for microtubule attachment during mitosis. Centromere identity in humans is epigenetically determined, with no DNA sequence either necessary or sufficient. A prime candidate for the epigenetic mark is assembly into centromeric chromatin of centromere protein A (CENP-A), a histone H3 variant found only at functional centromeres. A new covalent fluorescent pulse-chase labeling approach using SNAP tagging has now been developed and is used to demonstrate that CENP-A bound to a mature centromere is quantitatively and equally partitioned to sister centromeres generated during S phase, thereby remaining stably associated through multiple cell divisions. Loading of nascent CENP-A on the megabase domains of replicated centromere DNA is shown to require passage through mitosis but not microtubule attachment. Very surprisingly, assembly and stabilization of new CENP-A–containing nucleosomes is restricted exclusively to the subsequent G1 phase, demonstrating direct coupling between progression through mitosis and assembly/maturation of the next generation of centromeres.
Multiple Independent Genetic Factors at NOS1AP Modulate the QT Interval in a Multi-Ethnic Population

Extremes of electrocardiographic QT interval are associated with increased risk for sudden cardiac death (SCD); thus, identification and characterization of genetic variants that modulate QT interval may elucidate the underlying etiology of SCD. Previous studies have revealed an association between a common genetic variant in NOS1AP and QT interval in populations of European ancestry, but this finding has not been extended to other ethnic populations. We sought to characterize the effects of NOS1AP genetic variants on QT interval in the multi-ethnic population-based Dallas Heart Study (DHS, n = 3,072). The SNP most strongly associated with QT interval in previous samples of European ancestry, rs16847548, was the most strongly associated in White (P = 0.005) and Black (P = 3.6×10−5) participants, with the same direction of effect in Hispanics (P = 0.17), and further showed a significant SNP × sex-interaction (P = 0.03). A second SNP, rs16856785, uncorrelated with rs16847548, was also associated with QT interval in Blacks (P = 0.01), with qualitatively similar results in Whites and Hispanics. In a previously genotyped cohort of 14,107 White individuals drawn from the combined Atherosclerotic Risk in Communities (ARIC) and Cardiovascular Health Study (CHS) cohorts, we validated both the second locus at rs16856785 (P = 7.63×10−8), as well as the sex-interaction with rs16847548 (P = 8.68×10−6). These data extend the association of genetic variants in NOS1AP with QT interval to a Black population, with similar trends, though not statistically significant at P<0.05, in Hispanics. In addition, we identify a strong sex-interaction and the presence of a second independent site within NOS1AP associated with the QT interval. These results highlight the consistent and complex role of NOS1AP genetic variants in modulating QT interval.
Stress preservation in German loan words

It has been a well known fact from the very beginning of generative phonology that morphologically complex forms often inherit characteristics of related, morphologically less complex forms (Chomsky & Halle 1968) . Take for example the contrast in stress pattern of the English words Tatamagouchi and originality, both consisting of the same number of (light) syllables preceding main stress. 1 Secondary stress falls on the first syl lable of the underived
Positivity Can Cue Familiarity

Given that familiarity is closely associated with positivity, the authors sought evidence for the idea that positivity would increase perceived familiarity. In Experiment 1, smiling and thus positively perceived novel faces were significantly more likely to be incorrectly judged as familiar than novel faces with neutral expressions. In Experiment 2, subliminal association with positive affect (a positively valenced prime) led to false recognition of novel words as familiar. In Experiment 3, validity judgments, known to be influenced by familiarity, were more likely to occur if participants were in happy mood states than neutral mood states. Despite their different paradigms and approaches, the results of these three studies converge on the idea that, at least under certain circumstances, the experience of positivity itself can signal familiarity, perhaps because the experience of familiarity is typically positive.
Reflecting on the efficacy of SODA and cognitive mapping for problem analysis in information requirements determination

Information requirements determination (IRD) is arguably one of the most challenging and important tasks of information systems development (ISD). This paper reports on an action research study which involved the use of a soft management science/operational research approach, namely Strategic Options Development and Analysis (SODA) and its accompanying technique, cognitive mapping, applied to the IRD task. A central aspect of the study is a set of reflections on the efficacy of SODA and cognitive mapping in helping to overcome the critical challenges of IRD. The authors believe that several significant lessons of importance for IRD have been illustrated and established. Furthermore the authors believe to have demonstrated that SODA and cognitive mapping embody a useful problem structuring and IRD process and technique that have key elements which would contribute to the work of today’s business analysts.
Localizing Recent Adaptive Evolution in the Human Genome

Identifying genomic locations that have experienced selective sweeps is an important first step toward understanding the molecular basis of adaptive evolution. Using statistical methods that account for the confounding effects of population demography, recombination rate variation, and single-nucleotide polymorphism ascertainment, while also providing fine-scale estimates of the position of the selected site, we analyzed a genomic dataset of 1.2 million human single-nucleotide polymorphisms genotyped in African-American, European-American, and Chinese samples. We identify 101 regions of the human genome with very strong evidence (p < 10−5) of a recent selective sweep and where our estimate of the position of the selective sweep falls within 100 kb of a known gene. Within these regions, genes of biological interest include genes in pigmentation pathways, components of the dystrophin protein complex, clusters of olfactory receptors, genes involved in nervous system development and function, immune system genes, and heat shock genes. We also observe consistent evidence of selective sweeps in centromeric regions. In general, we find that recent adaptation is strikingly pervasive in the human genome, with as much as 10% of the genome affected by linkage to a selective sweep.
Surgical Ablation of Refractory Ventricular Tachycardia in Patients With Nonischemic Cardiomyopathy

Background— The surgical approach for the treatment of ventricular tachycardia (VT) has been largely replaced by percutaneous, catheter-based techniques. However, some VT circuits, particularly in patients with nonischemic cardiomyopathy, remain inaccessible to percutaneous ablation. Surgical therapy of these VTs is an alternative approach; however, its methodology has not been well defined. The purpose of this study was to evaluate the efficacy of preoperative electroanatomic and electrophysiological characterization of the VT substrate and circuit to guide surgical ablation. Methods and Results— Eight patients with recurrent sustained VT refractory to antiarrhythmic drugs underwent endocardial and/or epicardial ablation procedures. Electroanatomic mapping was performed, and the VT substrate and circuit(s) were defined using voltage, activation, entrainment, and pace mapping. All 8 patients underwent detailed endocardial mapping; 6 patients also underwent epicardial mapping. Radiofrequency ablation was performed with the use of an open-irrigation catheter. After the unsuccessful percutaneous approach, surgical cryoablation was applied to the sites previously identified and targeted during the percutaneous procedure. There were no significant perioperative complications. During a mean follow-up period of 23±6 months (range, 15 to 34 months), 6 patients had significant reduction in VT burden as evident by a reduced number of implantable cardioverter-defibrillator shocks after ablation (6.6 to 0.6 shocks per patient; P=0.026). Two patients died, one of progressive heart failure and one of sepsis. Conclusions— VT circuits inaccessible to percutaneous ablation techniques are rare but can be encountered in patients with nonischemic cardiomyopathy. These VTs can be successfully targeted by surgical cryoablation guided by preoperative electroanatomic and electrophysiological mapping.
The Basal Ganglia and Cortex Implement Optimal Decision Making Between Alternative Actions

Neurophysiological studies have identified a number of brain regions critically involved in solving the problem of action selection or decision making. In the case of highly practiced tasks, these regions include cortical areas hypothesized to integrate evidence supporting alternative actions and the basal ganglia, hypothesized to act as a central switch in gating behavioral requests. However, despite our relatively detailed knowledge of basal ganglia biology and its connectivity with the cortex and numerical simulation studies demonstrating selective function, no formal theoretical framework exists that supplies an algorithmic description of these circuits. This article shows how many aspects of the anatomy and physiology of the circuit involving the cortex and basal ganglia are exactly those required to implement the computation defined by an asymptotically optimal statistical test for decision making: the multihypothesis sequential probability ratio test (MSPRT). The resulting model of basal ganglia provides a new framework for understanding the computation in the basal ganglia during decision making in highly practiced tasks. The predictions of the theory concerning the properties of particular neuronal populations are validated in existing experimental data. Further, we show that this neurobiologically grounded implementation of MSPRT outperforms other candidates for neural decision making, that it is structurally and parametrically robust, and that it can accommodate cortical mechanisms for decision making in a way that complements those in basal ganglia.
BOD and DO modeling for Tigris River at Baghdad city portion using QUAL2K model

This study was conducted within Baghdad portion of Tigris River, which is significant due to the presence of various drains joining the river. Water samples have been collected from Tigris River along different points between Alfahama to Al-Zafarania and were analyzed for various water quality parameters during low flow season (November). The study involves application of QUAL2K model to simulate and predict the dissolved oxygen (DO) and biochemical oxygen demand (BOD5) profiles of Tigris River in a stretch of 49.97 kilometer. Remote sensing &GIS technique (ERDAS 9.2 & Global Mapper 11) used in this study as supported software to provide some QUAL2K input data related to the river geometric parameter. The simulation results were verified and showed that the predicted values were in agreement with the measured values. Model output showed that DO in the entire river was within limit of not less than 4 mg/L. For CBOD, the entire river may be divided into three reaches; first one is extended from AlFahama (0 km) to Alkadhmiah (9 km) and have CBOD concentration of 2 mg/L and the second reach has CBOD range (2–4) mg/L in which begins from Alkadhmiah and extend to near Aldora refinery. The third reach extends from Aldora refinery to Al-Zafaraniah (49.97) in the south before river confluence with Diyala River which has CBOD concentrations of more than 4 mg/L. The most polluted zone in the river located downstream of Aldora refinery and extend to the last segment due to the industrial discharge of pollutants to the river. Two strategies were suggested to control the level of CBOD in the river. First strategy suggest that the CBOD of the discharged effluent from industries should not exceed at least 50 mg/L to keep the CBOD of the entire river within limits of not more than 4 mg/L. While the second strategy does not give significant results in which the level of CBOD increase even with reduction in the pollution load (point source).