Miracle-dz/UniFAR-FTUs huggingface dataset:
Examining the Influence of Perceptions of a Supervisor's Leadership Style on Levels of Psychological Ownership among Entry Level Professionals.

Patrick Pauken, Advisor The purpose of this study was to explore the relationship between the perceived leadership behaviors of upper-level student affairs officers and levels of psychological ownership among entry-level employees working in student services roles in higher education in the United States. Specifically, this study identified whether there are leadership behaviors, as measured by the Multifactor Leadership Questionnaire (Bass & Avolio, 2004), that relate to higher feelings of psychological ownership as measured by the Psychological Ownership Questionnaire (Avey & Avolio, 2007) among entry-level professionals. The relationships between institution type and leadership style and psychological ownership were also assessed. Both the MLQ and POQ are valid and reliable instruments (Avey, Avolio, Corssley, & Luthans, 2009; Bass & Avolio, 2004); however, the responses of the participants in this study did not align with the models as proposed by the developers of the instruments. Based on the results of exploratory factor analysis, the models were modified. The new modified models reflected the overarching theoretical constructs of the original models. Significant results were found in the relationship between participants’ perceptions of leadership as measured in the MLQ and their feeling of psychological ownership as measured in the POQ. Additionally, there were several combinations of MLQ predictor variables which resulted in higher levels of psychological ownership, including Inspirational Motivation, Intellectual Stimulation, Management-by-Exception Active, Individual Consideration, and Laissez faire. Surprisingly, neither perceptions of leadership nor feelings of psychological ownership were influenced by the type of institution were participants were employed.
Using Learning Styles and Preferences to Incorporate Emerging E-Learning Tools in Teaching

Emerging e-learning tools have the potential to enrich academic environments. However, there is a need to understand the requirements, expectations, and learning styles of the end users before incorporating new tools into courses. This paper presents details of a user study to analyze learning styles and tools preferences of the end users and to explore significant relationships among them. The study outcomes highlight several significant relationships and reveal the tools preferences of various learner types. In contrast with existing studies, our study report balanced or unbiased academic performances across all learner types.
Interaction of Baseline Characteristics With The Hazard of Encainide, Flecainide, and Moricizine Therapy in Patients With Myocardial Infarction: A Possible Explanation for Increased Mortality in the Cardiac Arrhythmia Suppression Trial (CAST)

BackgroundThe Cardiac Arrhythmia Suppression Trial (CAST) was designed to test the hypothesis that suppression of ventricular ectopy with antiarrhythmic drugs after a myocardial infarction reduces the incidence of sudden arrhythmic death. Patients in whom ventricular ectopy could be suppressed with encainide, flecainide, or moricizine were randomly assigned to receive either active drug or placebo. The encainide and flecainide arms of the study were discontinued in 1989 (CAST-I) and the moricizine arm in 1991 (CAST-II) because of excess mortality. To explore the mechanisms of these adverse outcomes, we examined the interaction of baseline characteristics with the hazard of therapy with encainide, flecainide, or moricizine compared with their respective placebos. Methods and ResultsCAST-I comprised 755 patients assigned to flecainide or encainide and 743 patients assigned to placebo, whereas in CAST-II, 502 patients received moricizine and 491 patients received placebo. Clinical and laboratory baseline variables of patients receiving active drug and those receiving placebo were similar. In CAST-I patients, there was a significant interaction of active therapy with both all-cause death/cardiac arrest and arrhythmic death/cardiac arrest for non-Q-wave myocardial infarction (total mortality hazard ratios, 1.8 versus 7.9 for Q-wave versus non–Q-wave infarction, P = .03). Ventricular premature depolarization (VPD) frequency ≥ 50/h and heart rate ≥ 74 beats per minute each interacted significantly with total mortality/cardiac arrest only. In the sicker CAST-II patients (ejection fraction ≤ 40%), only diuretic use at baseline interacted significantly with moricizine use for both all-cause death/cardiac arrest and arrhythmic death/cardiac arrest (total mortality hazard ratios, 1.9 versus 0.7 for diuretic use versus no use, P = .01). ConclusionsAlthough active treatment in CAST- I was associated with greater mortality than placebo with respect to almost all baseline variables, the therapeutic hazard was more than expected in patients with non–Q-wave myocardial infarction and (for total mortality) frequent premature VPDs and higher heart rates, suggesting that the adverse effect of encainide or flecainide therapy is greater when ischemic and electrical instability are present. The relative hazard of therapy with moricizine in the sicker CAST-II population was greater in those using diuretics. Thus, although these drugs have the common ability to suppress ventricular ectopy after myocardial infarction, their detrimental effects on survival may be mediated by different mechanisms in different populations, emphasizing the complex, poorly understood hazards associated with antiarrhythmic drug treatment.
Labour Market Frictions, Monetary Policy and Durable Goods

The standard two-sector monetary business cycle model suffers from an important deficiency. Since durable good prices are more flexible than non-durable good prices, optimising households build up the stock of durable goods at low cost after a monetary contraction. Consequently, sectoral outputs move in opposite directions. This paper finds that labour market frictions help to understand the so-called sectoral “comovement puzzle”. Our benchmark model with staggered Right-to-Manage wage bargaining closely matches the empirical elasticities of output, employment and hours per worker across sectors. The model with Nash bargaining, in contrast, predicts that firms adjust employment exclusively along the extensive margin.
The Topography of White Mater Peri-Ventricular Hyperintensities on Brain Magnetic Resonance Imagings (MRI) Among Cameroonians

Background: Peri-Ventricular Hyperintensity (PVH) refers to bright signal adjacent to lateral ventricles on T2 weighted (T2W) and Fluid Attenuated Inversion Recovery (FLAIR) brain MR images. It is a qualitative evaluation of white mater lesions. Aim: Evaluating the incidence and topographic distribution of cerebral periventricular hyperintensities among Cameroonians using FLAIR and T2W brain MR images. Materials and methods: Prospective study of patients who came for brain MRI from June 2009 to Febuary 2010. Patients were scanned after data documentation with AIRIS 11 0.3 Tesla imager starting from medullo-cervical cord junction. Axial T2W and FLAIR images were acquired using 6-8mm slice tissue thickness and 0.5-1 mm intersection gap. Images were evaluated qualitatively into absent, type 1-3 PVH. Type 1-peri-ventricular frontal capping, rimming or thin smooth halo. Type 2-PVH extends into deep white mater. Type 3-PVH extends into sub-cortical white mater. Inclusion criteria included reportable quality images. Results were analysed with Computer statistical package SPSS 13 Results: Ninety seven patients with 60 (61.86%), males and 37 (38.14%) females were studied. Age range was 0- 89 with mean of 44.5. 75.26% of all cases, 70% of all males and 83.78% of all females had absent PVH. 24.74% (n=24, M: F=3:1) of studied population had PVH, shared into 33.33% type 1 PVH, 58.33% type 2 and 8.33% type 3. Peaks of type 2 PVH in males and females were 60-69 and 70-79 respectively. The commonest association of type 2 PVH in males and females were CVD (62%) and cerebral atrophy (50%) respectively. Conclusion: The incidence rate of PVH among Cameroonians without population bias is 24.74% with male earlier onset and predominance. PVH is common and severer among elderly (50 years and above). The predominant type of PVH in both sexes is type 2 with commonest association in males being CVD but cerebral atrophy in females.
The Value of Online Algorithms to Predict T-Cell Ligands Created by Genetic Variants

Allogeneic stem cell transplantation can be a curative treatment for hematological malignancies. After HLA-matched allogeneic stem cell transplantation, beneficial anti-tumor immunity as well as detrimental side-effects can develop due to donor-derived T-cells recognizing polymorphic peptides that are presented by HLA on patient cells. Polymorphic peptides on patient cells that are recognized by specific T-cells are called minor histocompatibility antigens (MiHA), while the respective peptides in donor cells are allelic variants. MiHA can be identified by reverse strategies in which large sets of peptides are screened for T-cell recognition. In these strategies, selection of peptides by prediction algorithms may be relevant to increase the efficiency of MiHA discovery. We investigated the value of online prediction algorithms for MiHA discovery and determined the in silico characteristics of 68 autosomal HLA class I-restricted MiHA that have been identified as natural ligands by forward strategies in which T-cells from in vivo immune responses after allogeneic stem cell transplantation are used to identify the antigen. Our analysis showed that HLA class I binding was accurately predicted for 87% of MiHA of which a relatively large proportion of peptides had strong binding affinity (56%). Weak binding affinity was also predicted for a considerable number of antigens (31%) and the remaining 13% of MiHA were not predicted as HLA class I binding peptides. Besides prediction for HLA class I binding, none of the other online algorithms significantly contributed to MiHA characterization. Furthermore, we demonstrated that the majority of MiHA do not differ from their allelic variants in in silico characteristics, suggesting that allelic variants can potentially be processed and presented on the cell surface. In conclusion, our analyses revealed the in silico characteristics of 68 HLA class I-restricted MiHA and explored the value of online algorithms to predict T-cell ligands that are created by genetic variants.
Effects of Goal Framing and Emotions on Perceived Threat and Willingness to Sacrifice for Climate Change

This study explores discrete emotions (guilt, fear, hope) as mediators for effects of goal framing on perceived threat of climate change and willingness to sacrifice. To reconcile conflicting evidence, the study introduces and tests the distinction between gain-positive frames (positive consequences of engaging in climate protection), gain-negative frames (avoiding negative consequences when engaging in climate protection), and loss frames (negative consequences of not engaging in climate protection). Results show that gain-negative frames increase perceived threat and willingness to sacrifice, while loss frames increase them through guilt and fear. Hope is increased by a gain-positive frame but subsequently lowers both outcomes.
Pengaruh Skill Representasi Matematis Terhadap Hasil Belajar Siswa Menggunakan Model Discovery Learning

Most of the students assume that physics is one of the difficulties and boring subjects because a lot of formulas and concepts of physics that should be memorized. Therefore, this research aims to determine the effect of mathematical representation skill of learning outcomes using Discovery Learning model with Newton's Laws of Motion as the main topic. This research was conducted at SMA Negeri 2 Pringsewu in the second semester of academic year 2016/2017. The samples were 35 students in class X MIPA 1. The learning design was One Shot Case Study Design. Based on the results of simple linear regression test showed that there was a linear effect positive and significant correlation between skill to the mathematical representation of student learning outcomes using Discovery Learning model.Banyak siswa yang menganggap bahwa fisika merupakan salah satu mata pelajaran yang sulit dan membosankan karena banyak rumus dan konsep fisika yang harus dihapal. Oleh karena itu, penelitian ini dilakukan untuk mengetahui pengaruh skill representasi matematis terhadap hasil belajar siswa menggunakan model pembelajaran Discovery Learning pada materi pokok Hukum Newton tentang Gerak. Penelitian ini dilakukan di SMA Negeri 2 Pringsewu semester genap tahun ajaran 2016/2017. Sampel penelitian adalah kelas X MIPA 1 berjumlah 35 siswa, dengan desain penelitian One Shot Case Study Design. Berdasarkan hasil uji regresi linear sederhana ditunjukkan bahwa terdapat pengaruh linear yang positif dan signifikan antara skill representasi matematis tehadap hasil belajar siswa menggunakan model Discovery Learning.
The impact of due diligence in seasoned equity offerings

A series of deregulatory reforms have promoted accelerated equity issuance at the expense of adequate time for underwriter due diligence. These reforms have gained wide acceptance, raising doubts about the value of due diligence investigations for today’s large seasoned issuers. However, recent high-profile corporate scandals indicate that due diligence matters. We hypothesize that low quality issuers prefer accelerated offers and that high quality issuers, in contrast, signal their quality by allowing more time for underwriters to perform due diligence. We provide support for this hypothesis using a battery of tests that examine stock valuation and earnings quality around equity offers. JEL Classification: G14, G24, G32
Therapeutic response and side effects of repeated radioligand therapy with 177Lu-PSMA-DKFZ-617 of castrate-resistant metastatic prostate cancer

Prostate-specific membrane antigen (PSMA) is highly expressed on prostate epithelial cells and strongly up-regulated in prostate cancer (PC), making it an optimal target for the treatment of metastasized PC. Radioligand therapy (RLT) with 177Lu-PSMA-DKFZ-617 (Lu-PSMA) is a targeted therapy for metastatic PC. In this study, we retrospectively analyzed the side effects and the response rate of 24 hormone and/or chemorefractory PC patients with a mean age of 75.2 years (range: 64–82) with distant metastases and progressive disease according to the PSA level, who were treated with Lu-PSMA. Median PSA was 522 ng/ml (range: 17–2360). Forty-six cycles of Lu-PSMA were performed. Of the 24 patients, 22 received two cycles. Eight weeks after the first cycle of Lu-PSMA therapy 79.1% experienced a decline in PSA level. Eight weeks after the second cycle of Lu-PSMA therapy 68.2% experienced a decline in PSA relative to the baseline value. Apart from two cases of grade 3 anemia, there was no relevant hemato- or nephrotoxicity (grade 3 or 4). These results confirmed that Lu-PSMA is a safe treatment option for metastatic PC patients and has a low toxicity profile. A positive response to therapy in terms of decline in PSA occurs in about 70% of patients.
SS1 (NAL1)- and SS2-Mediated Genetic Networks Underlying Source-Sink and Yield Traits in Rice (Oryza sativa L.)

Source leaf/sink capacity (SS) traits are important determinants of grain yield (GY) of rice. To understand the genetic basis of the SS relationship in rice, five SS and GY traits of rice were genetically dissected using two reciprocal introgression populations. Seventy-three QTL affecting the SS and GY traits were identified, most of which were detected in one of the parental genetic backgrounds (GBs). Two major QTL at bins 4.7 (SS1) and 3.12 (SS2) were associated consistently with all measured SS and yield traits in both GBs across two contrasting environments. Strong interactions between SS1/SS2 and the detected QTL led us to the discovery of genetic networks affecting the SS and GY traits. The SS1 acted as a regulator controlling two groups of downstream QTL affecting the source leaf width and grain number per panicle (GNP). SS2 functioned as a regulator positively regulating different groups of downstream QTL affecting the source leaf length, GNP, grain weight, and GY. Map-based cloning of SS1 indicates that SS1 is NAL1 involved in polar auxin/IAA transport. Different alleles at NAL1 were apparently able to qualitatively and/or quantitatively control the IAA transport from the apical meristem to different plant tissues and thus regulate those downstream loci/pathways controlling different SS traits of rice. There was a functional allele and a non-functional mutation in the parents at each of the QTL downstream of SS1 or SS2, which were detectable only in the presence of the functional allele of SS1 or SS2. Our results provided direct evidence that SS and yield traits in rice are controlled by complex signaling pathways and suggest further improvement of rice yield potential with enhanced and balanced SS relationships can be achieved by accurately manipulating allelic combinations at loci in the SS1 and SS2 mediated pathways.
Statistical Inference of Selection and Divergence from a Time-Dependent Poisson Random Field Model

We apply a recently developed time-dependent Poisson random field model to aligned DNA sequences from two related biological species to estimate selection coefficients and divergence time. We use Markov chain Monte Carlo methods to estimate species divergence time and selection coefficients for each locus. The model assumes that the selective effects of non-synonymous mutations are normally distributed across genetic loci but constant within loci, and synonymous mutations are selectively neutral. In contrast with previous models, we do not assume that the individual species are at population equilibrium after divergence. Using a data set of 91 genes in two Drosophila species, D. melanogaster and D. simulans, we estimate the species divergence time (or 1.68 million years, assuming the haploid effective population size years) and a mean selection coefficient per generation . Although the average selection coefficient is positive, the magnitude of the selection is quite small. Results from numerical simulations are also presented as an accuracy check for the time-dependent model.
HINKEL kinesin, ANP MAPKKKs and MKK6/ANQ MAPKK, which phosphorylates and activates MPK4 MAPK, constitute a pathway that is required for cytokinesis in Arabidopsis thaliana

Cytokinesis is regulated to ensure the precise partitioning of cytoplasm and duplicated chromosomes to daughter cells. The NACK-PQR pathway, which includes NACK1 kinesin-like protein (KLP) and a mitogen-activated protein kinase (MAPK) cascade, plays a key role in cytokinesis in tobacco cells. Although HINKEL/AtNACK1 (HIK) KLP, ANP MAP kinase kinase kinases (MAPKKKs) and MKK6/ ANQ MAP kinase kinase (MAPKK) have been identified independently as regulators of cytokinesis in Arabidopsis thaliana, the involvement of HIK, ANPs and MKK6/ANQ in a regulatory cascade remains to be demonstrated. Here we provide details of the protein kinase pathway that controls cytokinesis in A. thaliana. Analysis of the subcellular distribution of six MAPKKs of A. thaliana that had been fused to green fluorescent protein revealed that only MKK6/ANQ protein was concentrated at the equatorial plane of the phragmoplast, at the site of localization of HIK. Expression of MKK6/ANQ in yeast cells replaced the growth-control function of the MAPKK encoded by yeast PBS2, provided that both ANP1 MAPKKK and HIK [or TETRASPORE/AtNACK2 (TES)] KLP were coexpressed, suggesting that ANP1 activates MKK6/ANQ in the presence of HIK (or TES). Coexpression of HIK and ANP3 (another member of the ANP MAPKKK family) weakly activated MKK6/ANQ but that of TES and ANP3 did not. MKK6/ANQ phosphorylated MPK4 MAPK in vitro to activate the latter kinase. Thus cytokinesis in A. thaliana is controlled by a pathway that consists of ANP MAPKKKs that can be activated by HIK and MKK6/ANQ MAPKK, with MPK4 MAPK being a probable target of MKK6/ANQ.
Veteran adjustment to civilian life: a research portfolio

s, which may have also excluded some of the relevant literature and led to a publication bias. Excluding unpublished or grey literature has the potential to reduce the validity of the findings, as there is a risk that the systematic review only examines positively biased, clinically relevant or significant results and therefore may wrongly assume that this is an accurate representation of the whole evidence base (Blackhall &
A digital architecture for support vector machines: theory, algorithm, and FPGA implementation

In this paper, we propose a digital architecture for support vector machine (SVM) learning and discuss its implementation on a field programmable gate array (FPGA). We analyze briefly the quantization effects on the performance of the SVM in classification problems to show its robustness, in the feedforward phase, respect to fixed-point math implementations; then, we address the problem of SVM learning. The architecture described here makes use of a new algorithm for SVM learning which is less sensitive to quantization errors respect to the solution appeared so far in the literature. The algorithm is composed of two parts: the first one exploits a recurrent network for finding the parameters of the SVM; the second one uses a bisection process for computing the threshold. The architecture implementing the algorithm is described in detail and mapped on a real current-generation FPGA (Xilinx Virtex II). Its effectiveness is then tested on a channel equalization problem, where real-time performances are of paramount importance.
The COPD assessment test and St George’s Respiratory Questionnaire: are they equivalent in subjects with COPD?

Background The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is a short questionnaire that has facilitated health status measurements in subjects with COPD. However, it remains controversial as to whether the CAT can be used as a suitable substitute for the St George’s Respiratory Questionnaire (SGRQ). This study investigated the reliability and score distributions of the CAT and SGRQ and evaluated which factors contributed to health status for each questionnaire. Methods A total of 109 consecutive subjects with stable COPD from a single center were enrolled in this study. Each subject completed pulmonary function tests, exercise tests, and the following self-administered questionnaires: the Baseline Dyspnea Index, the Hospital Anxiety and Depression Scale, the CAT, and SGRQ. Results Internal consistencies of CAT and SGRQ total scores were both excellent (Cronbach’s α coefficients =0.890 and 0.933). Statistically significant correlations were observed between CAT and SGRQ total scores (R=0.668, P<0.001). Correlations of CAT scores with parameters related to pulmonary function, dyspnea, exercise performance, and psychological factors were inferior to correlations with those parameters with SGRQ total scores. Both multiple regression analyses and principal component analyses revealed that there were slight differences between SGRQ total scores and CAT scores. Conclusion The CAT is similar to SGRQ in terms of discriminating health status. However, we demonstrated that what is assessed by the CAT may differ slightly from what is measured by SGRQ.