Miracle-dz/UniFAR-FTUs huggingface dataset:
Urinary incontinence—pharmacotherapy options

Abstract The impact of incontinence is felt by millions of people worldwide, with tremendous decrement in quality of life and enormous cost reaching billions of dollars. Urinary incontinence is defined as ‘involuntary leakage of urine’ and is categorized into two main types: urgency urinary incontinence (UUI) and stress urinary incontinence (SUI). Behavioral modifications and pharmacologic therapies, primarily antimuscarinic agents, are the mainstay of treatment for UUI. These drugs are moderately efficacious but have troublesome side-effects, the combination resulting in poor compliance and persistence with therapy. There are several agents on the market today, each with some variation in pharmacologic properties. Whether these translate into meaningful differences in clinical efficacy and tolerability remains a matter of debate. Treatment of SUI has seen little success with pharmacologic therapy. In Europe, duloxetine is approved for treatment of SUI with marginal success rates; this drug, although available in the United States for treatment of depression, is not approved for SUI. The search for newer and better pharmacologic options and novel therapies is on-going, fueled primarily by the high prevalence of bothersome incontinence and the tremendous number of health care dollars spent on current therapy. This review addresses pharmacologic options for treatment of urinary incontinence.
Solvability by radicals is in polynomial time

Every high school student knows how to express the roots of a quadratic equation in terms of radicals; what is less well-known is that this solution was found by the Babylonians a millenia and a half before Christ [Ne]. Three thousand years elapsed before European mathematicians determined how to express the roots of cubic and quartic equations in terms of radicals, and there they stopped, for their techniques did not extend. Lagrange published a treatise which discussed why the methods that worked for polynomials of degree less than five did not work for quintic polynomials [Lag], They require double exponential time. Through the years other mathematicians developed alternate algorithms all of which, however, remained exponential. A major impasse was the problem of factoring polynomials, for until the recent breakthrough of Lenstra, Lenstra, and Lovász [L3], all earlier algorithms had exponential running time. Their algorithm, which factors polynomials over the rationals in polynomial time, gave rise to a hope that some of the classical questions of Galois theory might have polynomial time solutions. Galois transformed the question of solvability by radicals from a problem concerning fields to a problem about groups. What we do is to change the inquiry into several problems concerning the solvability of certain primitive groups.
Joint categorization of queries and clips for web-based video search

Building a video search engine on the Web is a very challenging problem. Compared with web page search, video search has its unique characteristics (such as high volume of data for each video, existence of multi-modal information including meta-data, visual content, audio, closed caption, etc). In this paper, we investigate some promising approaches to boosting the search relevance of a large scale video search engine on the Web. The contribution of our work is three-fold. (1) We developed a specialized video categorization framework which combines multiple classifiers based on different modalities. (2) By learning users' querying history and clicking log, we proposed an automatic query profile generation technique and applied the profile to query categorization. (3) A highly scalable system was developed, which integrates the online query categorization and offline video categorization. Naive Bayes with mixture of multinomials, Maximum Entropy, and Support Vector Machine categorization methods and the profile learn-ing technique were evaluated on a large scale set of video data on the Web. The evaluation of the developed system and user study has indicated that the joint categorization of queries and video data boosts the video search relevance and user search experience. The high efficiency of our approaches is also demonstrated by the good responsiveness of the system for the video search engine on the Web.
Local, Private, Efficient Protocols for Succinct Histograms

We give efficient protocols and matching accuracy lower bounds for frequency estimation in the local model for differential privacy. In this model, individual users randomize their data themselves, sending differentially private reports to an untrusted server that aggregates them. We study protocols that produce a succinct histogram representation of the data. A succinct histogram is a list of the most frequent items in the data (often called "heavy hitters") along with estimates of their frequencies; the frequency of all other items is implicitly estimated as 0. If there are n users whose items come from a universe of size d, our protocols run in time polynomial in n and log(d). With high probability, they estimate the accuracy of every item up to error O(√{log(d)/(ε2n)}). Moreover, we show that this much error is necessary, regardless of computational efficiency, and even for the simple setting where only one item appears with significant frequency in the data set. Previous protocols (Mishra and Sandler, 2006; Hsu, Khanna and Roth, 2012) for this task either ran in time Ω(d) or had much worse error (about √[6]{log(d)/(ε2n)}), and the only known lower bound on error was Ω(1/√{n}). We also adapt a result of McGregor et al (2010) to the local setting. In a model with public coins, we show that each user need only send 1 bit to the server. For all known local protocols (including ours), the transformation preserves computational efficiency.
Gastrointestinal symptoms and weight loss in cancer patients receiving chemotherapy

Cancer patients receiving chemotherapy have a high risk of malnutrition secondary to the disease and treatment, and 40–80 % of cancer patients suffer from different degrees of malnutrition, depending on tumour subtype, location, staging and treatment strategy. Malnutrition in cancer patients affects the patient's overall condition, and it increases the number of complications, the adverse effects of chemotherapy and reduces the quality of life. The aim of the present study was to evaluate weight-loss prevalence depending on the tumour site and the gastrointestinal (GI) symptoms of oncology patients receiving chemotherapy. We included 191 cancer patients receiving chemotherapy. Files of all patients were reviewed to identify symptoms that might potentially influence weight loss. The nutritional status of all patients was also determined. The cancer sites in the patients were as follows: breast (31·9 %); non-colorectal GI (18·3 %); colorectal (10·4 %); lung (5·8 %); haematological (13·1 %); others (20·5 %). Of these patients, 58 % experienced some degree of weight loss, and its prevalence was higher among the non-colorectal GI and lung cancer patients. Common symptoms included nausea (59·6 %), anorexia (46 %) and constipation (31·9 %). A higher proportion of patients with ≥ 5 % weight loss experienced anorexia, nausea and vomiting (OR 9·5, 2·15 and 6·1, respectively). In conclusion, these results indicate that GI symptoms can influence weight loss in cancer patients, and they should be included in early nutritional evaluations.
Longer and Less Overlapping Food Webs in Anthropogenically Disturbed Marine Ecosystems: Confirmations from the Past

The human exploitation of marine resources is characterised by the preferential removal of the largest species. Although this is expected to modify the structure of food webs, we have a relatively poor understanding of the potential consequences of such alteration. Here, we take advantage of a collection of ancient consumer tissues, using stable isotope analysis and SIBER to assess changes in the structure of coastal marine food webs in the South-western Atlantic through the second half of the Holocene as a result of the sequential exploitation of marine resources by hunter-gatherers, western sealers and modern fishermen. Samples were collected from shell middens and museums. Shells of both modern and archaeological intertidal herbivorous molluscs were used to reconstruct changes in the stable isotopic baseline, while modern and archaeological bones of the South American sea lion Otaria flavescens, South American fur seal Arctocephalus australis and Magellanic penguin Spheniscus magellanicus were used to analyse changes in the structure of the community of top predators. We found that ancient food webs were shorter, more redundant and more overlapping than current ones, both in northern-central Patagonia and southern Patagonia. These surprising results may be best explained by the huge impact of western sealing on pinnipeds during the fur trade period, rather than the impact of fishing on fish populations. As a consequence, the populations of pinnipeds at the end of the sealing period were likely well below the ecosystem's carrying capacity, which resulted in a release of intraspecific competition and a shift towards larger and higher trophic level prey. This in turn led to longer and less overlapping food webs.
A hybrid current control for a controlled rectifier

A current controller must satisfy the contradictory requirements of having a fast dynamic response in transient and a low harmonic content in steady state, characteristics that are found in linear and hysteresis controllers, respectively. Predictive current controllers partly satisfy these requirements but at expenses of complexity. The present work proposes an alternative approach for modifying the linear controller in order to have a faster response. This consists of the One Cycle Control (OCC) current controller modified by the use of a lead-lag compensator. An additional feature of this controller is that it can be implemented with DSP. Besides mathematical analysis, simulation and experimental results are presented to validate the proposed controller.
Asymptotic solutions of diffusion models for risk reserves

We study a family of diffusion models for risk reserves which account for the investment income earned and for the inflation experienced on claim amounts. After we defined the process of the conditional probability of ruin over finite time and imposed the appropriate boundary conditions, classical results from the theory of diffusion processes turn the stochastic differential equation to a special class of initial and boundary value problems defined by a linear diffusion equation. Armed with asymptotic analysis and perturbation theory, we obtain the asymptotic solutions of the diffusion models (possibly degenerate) governing the conditional probability of ruin over a finite time in terms of interest rate.
Systemic Effects of Ulna Loading in Male Rats During Functional Adaptation

Functional skeletal adaptation is thought to be a local phenomenon controlled by osteoctyes. However, the nervous system also may have regulatory effects on adaptation. The aim of this study was to determine the effects of loading of a single bone on adaptation of other appendicular long bones and whether these responses were neuronally regulated. Young male Sprague‐Dawley rats were used. The right ulna was loaded to induce a modeling response. In other rats, a second regimen was used to induce bone fatigue with a mixed modeling/remodeling response; a proportion of rats from each group received brachial plexus anesthesia to induce temporary neuronal blocking during bone loading. Sham groups were included. Left and right long bones (ulna, humerus, tibia, and femur) from each rat were examined histologically 10 days after loading. In fatigue‐ and sham‐loaded animals, blood plasma concentrations of TNF‐α, RANKL, OPG, and TRAP5b were determined. We found that loading the right ulna induced an increase in bone formation in distant long bones that were not loaded and that this effect was neuronally regulated. Distant effects were most evident in the rats that received loading without bone fatigue. In the fatigue‐loaded animals, neuronal blocking induced a significant decrease in plasma TRAP5b at 10 days. Histologically, bone resorption was increased in both loaded and contralateral ulnas in fatigue‐loaded rats and was not significantly blocked by brachial plexus anesthesia. In young, growing male rats we conclude that ulna loading induced increased bone formation in multiple bones. Systemic adaptation effects were, at least in part, neuronally regulated. © 2010 American Society for Bone and Mineral Research.
On the error distance of extended Reed-Solomon codes

It is well known that the main problem of decoding the extended Reed-Solomon codes is computing the error distance of a word. Using some algebraic constructions, we are able to determine the error distance of words whose degrees are $k+1$ and $k+2$ to the extended Reed-Solomon codes. As a corollary, we can simply get the results of Zhang-Fu-Liao on the deep hole problem of Reed-Solomon codes.
Model for Deposition Build-up in Biomass Boilers

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Valences of Ti, Cr, and V in Apollo 17 high‐Ti and very low‐Ti basalts and implications for their formation

To assess the variability of redox states among mare basalt source regions, investigation of the valence of Ti, Cr, and V and the coordination environment of Ti in pyroxene and olivine in lunar rocks via XANES (X‐ray absorption near‐edge structure) spectroscopy has been extended to Apollo 17 basalts: two high‐Ti (70017 and 74275) hand samples, and three very low‐Ti (70006,371, 70007,289B, and 70007,296) basalt fragments from the Apollo 17 deep drill core. Valences of Ti in pyroxene of both suites range from 3.6 to 4, or from 40% to 0% Ti3+, averaging 15–20% Ti3+. Assuming Ti3+ is more compatible in pyroxene than Ti4+, then even lower Ti3+ proportions are indicated for the parental melts. The VLT pyroxene exhibits a slightly wider range of V valences (2.57–2.96) than the high‐Ti pyroxene (2.65–2.86) and a much wider range of Cr valences (2.32–2.80 versus 2.68–2.86); Cr is generally reduced in VLT pyroxene compared to high‐Ti pyroxene. Valences of Ti and Cr in VLT pyroxene become less reduced with increasing FeO contents, possibly indicating change in oxygen fugacity during crystallization. Olivine in all samples has very low (<20%) proportions of Ti3+, with no Ti3+ and higher proportions of Ti in tetrahedral coordination in the VLTs than in the high‐Ti basalts. Olivine in 74275, including that in a dunite clast, has much higher proportions of Cr2+ than the pyroxene in that sample, consistent with previous studies indicating that the olivine grains in this sample are xenocrysts and possibly indicating oxidation just prior to pyroxene crystallization. Results for this sample, the VLTs, and previously studied Apollo 14 and 15 basalts all indicate that mare magmas were in reducing environments at depth, as recorded in early crystallization products, and that later, presumably shallower environments, were relatively oxidizing; single, characteristic fO2s of formation cannot be assigned to these samples. A process likely to account for this feature seen in multiple samples is loss by degassing of a reducing, H‐rich vapor (probably H2) during ascent and/or eruption, causing oxidation of the residual melt, recorded in relatively late‐crystallized pyroxene.
Topological trends of internet content providers

The Internet is constantly changing, and its hierarchy was recently shown to become flatter. Recent studies of inter-domain traffic showed that large content providers drive this change by bypassing tier-1 networks and reaching closer to their users, enabling them to save transit costs and reduce reliance of transit networks as new services are being deployed, and traffic shaping is becoming increasingly popular. In this paper we take a first look at the evolving connectivity of large content provider networks, from a topological point of view of the autonomous systems (AS) graph. We perform a 5-year longitudinal study of the topological trends of large content providers, by analyzing several large content providers and comparing these trends to those observed for large tier-1 networks. We study trends in the connectivity of the networks, neighbor diversity and geographical spread, their hierarchy, the adoption of IXPs as a convenient method for peering, and their centrality. Our observations indicate that content providers gradually increase and diversify their connectivity, enabling them to improve their centrality in the Internet, while tier-1 networks lose dominance over time.
Mechanotransduction and flow across the endothelial glycocalyx

In this inaugural paper, we shall provide an overview of the endothelial surface layer or glycocalyx in several roles: as a transport barrier, as a porous hydrodynamic interface in the motion of red and white cells in microvessels, and as a mechanotransducer of fluid shearing stresses to the actin cortical cytoskeleton of the endothelial cell. These functions will be examined from a new perspective, the quasiperiodic ultrastructural model proposed in Squire et al. [Squire, J. M. , Chew, M. , Nneji, G. , Neal, C. , Barry, J. & Michel, C. (2001) J. Struct. Biol. 136, 239–255] for the 3D organization of the endothelial surface layer and its linkage to the submembranous scaffold. We shall show that the core proteins in the bush-like structures comprising the matrix have a flexural rigidity, EI, that is sufficiently stiff to serve as a molecular filter for plasma proteins and as an exquisitely designed transducer of fluid shearing stresses. However, EI is inadequate to prevent the buckling of these protein structures during the intermittent motion of red cells or the penetration of white cell microvilli. In these cellular interactions, the viscous draining resistance of the matrix is essential for preventing adhesive molecular interactions between proteins in the endothelial membrane and circulating cellular components.
Molecular epidemiology of noroviruses detected in seasonal outbreaks of acute nonbacterial gastroenteritis in Osaka City, Japan, from 1996–1997 to 2008–2009

In seasons from 1996–1997 through 2008–2009, noroviruses (NoVs) were detected in 505 outbreaks (71%) of nonbacterial gastroenteritis in Osaka City, Japan using molecular diagnosis with reverse transcription (RT)‐PCR or real‐time RT‐PCR. The occurrences of NoV‐associated outbreaks were related with the cold season during November–March (85.3%), and occasionally small epidemics of NoVs occurring during April–June were observed. Oyster‐associated outbreaks were dominant transmission modes (25–61.1%) before the 2003–2004 season, and decreased (5–20.5%) from the 2003–2004 season, although outbreaks attributable to food‐borne transmission (except for oysters) and person‐to‐person contact increased from the 2003–2004 season. The NoV strains were characterized into genotypes based on sequence analysis of partial capsid regions. Genotyping analyses identified at least 30 genotypes (12 in genogroup I [GI] and 18 in genogroup II [GII]) of NoV. The most common genotype was GII.4 (44.6%), followed in order by GII.3, GII.6, GII.2, and GII.5. The number of GII.4 NoVs increased greatly from the 2003–2004 season, eventually comprising a large share among the NoV‐ associated outbreaks (97.4%) of the 2006–2007 season. Occasional increased prevalence of genotypes other than GII.4 was observed during this study period. This study showed the appearance, spread, and disappearance of various genotypes and the change of NoV epidemic in a limited geographic region. Continuous NoV molecular surveillance is important for understanding NoV infections and for improving measures for their control and prevention. J. Med. Virol. 82:2097–2105, 2010. © 2010 Wiley‐Liss, Inc.
Compressed Scaling of Abstract Numerosity Representations in Adult Humans and Monkeys

There is general agreement that nonverbal animals and humans endowed with language possess an evolutionary precursor system for representing and comparing numerical values. However, whether nonverbal numerical representations in human and nonhuman primates are quantitatively similar and whether linear or logarithmic coding underlies such magnitude judgments in both species remain elusive. To resolve these issues, we tested the numerical discrimination performance of human subjects and two rhesus monkeys (Macaca mulatta) in an identical delayed match-to-numerosity task for a broad range of numerosities from 1 to 30. The results demonstrate a noisy nonverbal estimation system obeying Weber's Law in both species. With average Weber fractions in the range of 0.51 and 0.60, nonverbal numerosity discriminations in humans and monkeys showed similar precision. Moreover, the detailed analysis of the performance distributions exhibited nonlinearly compressed numerosity representations in both primate species. However, the difference between linear and logarithmic scaling was less pronounced in humans. This may indicate a gradual transformation of a logarithmic to linear magnitude scale in human adults as the result of a cultural transformation process during the course of mathematical education.
Use of palmitoylethanolamide in the entrapment neuropathy of the median in the wrist.

AIM Carpal tunnel syndrome (CTS) is a medical condition in which the median nerve is compressed, leading to discomfort and pain. Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, able to modulate inflammatory cell reactivity and pain. This study deals with the capability of PEA to normalize the electroneurographic alterations associated with moderate CTS. METHODS Patients displaying moderate CTS were enrolled and daily PEA (600 mg or 1 200 mg/die) was administered for 30 days. Control group received no treatment. RESULTS PEA treatment significantly improved the CTS-induced reduction of median nerve latency time (P<0.0004); PEA effect was dose-dependent. Tinel's sign presence and symptoms of discomfort were also reduced. CONCLUSION Although further studies are needed to better characterize PEA effect, the present report represents the first evidence on the improvement of distal motor latency elicited by PEA in patients with moderate CTS. The data support the hypothesis of protection against inflammatory and neuropathic pain by PEA.