Miracle-dz/UniFAR-FTUs huggingface dataset:
A molecular pathological study of four cases of ciliated muconodular papillary tumors of the lung

Ciliated muconodular papillary tumors (CMPTs) are a recently categorized benign or low‐grade malignant neoplasm that develops in the peripheral lung. Only about 40 cases have been reported to date, and the clinicopathological characteristics have yet to be defined in detail. Here, we present four cases of CMPTs with a focus on their immunohistochemical profiles and driver gene mutations. These tumors were a papillary proliferation of a mixture of ciliated, mucous, and basal cells located in the peripheral lung. Ciliated, mucous and basal cells were positive for TTF‐1 when using the clone SPT24, but negative for HNF‐4α. Basal cells were positive for p40. Mucous cells in some tumors were positive for MUC5AC and MUC6. The Ki‐67 index was less than 5%, and strong expression of p53 was not detected. Three of the four tumors had a BRAF (V600E) driver mutation, an EGFR (del E746‐T751/S752V) driver mutation, or driver mutations in both EGFR (E709G) and KRAS (G12V). These mutation types are rare for any histological type of lung cancer. The present results confirmed that CMPT is a neoplasm with immunohistochemical features and driver gene mutations that are distinct from those of common lung tumors.
Training and performance characteristics among Norwegian

This study quantified changes in training volume, organization, and physical capacity among Norwegian rowers winning international medals between 1970 and 2001. Twenty-eight athletes were identified (27 alive). Results of physiological testing and performance history were available for all athletes. Twenty-one of 27 athletes responded to a detailed questionnaire regarding their training during their internationally competitive years. Maximal oxygen uptake (VO2max) increased 12% (6.5 0.4 vs. 5.8 0.2Lmin ) from the 1970s to the 1990s. Similarly, 6-min ergometer rowing performance increased almost 10%. Three major changes in training characteristics were identified: (1) training at a low blood lactate (o2mM) increased from 30 to 50 hmonth 1 and race pace and supra-maximal intensity training ( 8–14mM lactate) decreased from 23 to 7 hmonth ; (2) training volume increased by 20%, from 924 to 1128 h yr ; (3) altitude training was used as a pre-competition peaking strategy, but it is now integrated into the winter preparation program as periodic 2–3-week altitude camps. The training organization trends are consistent with data collected on athletes from other sports, suggesting a ‘‘polarized’’ pattern of training organization where a high volume of low intensity training is balanced against regular application of training bouts utilizing 90%–95% of VO2max.
Comparative phylogeography of two seastars and their ectosymbionts within the Coral Triangle

Repeated exposure and flooding of the Sunda and Sahul shelves during Pleistocene sea‐level fluctuations is thought to have contributed to the isolation and diversification of sea‐basin populations within the Coral Triangle. This hypothesis has been tested in numerous phylogeographical studies, recovering an assortment of genetic patterns that the authors have generally attributed to differences in larval dispersal capability or adult habitat specificity. This study compares phylogeographical patterns from mitochondrial COI sequences among two co‐distributed seastars that differ in their adult habitat and dispersal ability, and two seastar ectosymbionts that differ in their degree of host specificity. Of these, only the seastar Linckia laevigata displayed a classical pattern of Indian‐Pacific divergence, but with only moderate genetic structure (ΦCT = 0.067). In contrast, the seastar Protoreaster nodosus exhibited strong structure (ΦCT = 0.23) between Teluk Cenderawasih and the remainder of Indonesia, a pattern of regional structure that was echoed in L. laevigata (ΦCT = 0.03) as well as its obligate gastropod parasite Thyca crystallina (ΦCT = 0.04). The generalist commensal shrimp, Periclimenes soror showed little genetic structuring across the Coral Triangle. Despite species‐specific phylogeographical patterns, all four species showed departures from neutrality that are consistent with massive range expansions onto the continental shelves as the sea levels rose, and that date within the Pleistocene epoch. Our results suggest that habitat differences may affect the manner in which species responded to Pleistocene sea‐level fluctuations, shaping contemporary patterns of genetic structure and diversity.
Genetic Analysis of Philippine Native Pigs ( Sus scrofa L . ) Using Microsatellite Loci

1 Genomic Informatics Center, Hankyong National University Anseong 456-749, Republic of Korea; 2 Department of Animal Life and Environmental Science, Hankyong National University, Anseong 456-749, Republic of Korea; 3 Department of Animal Science, College of Life Sciences, Pusan National University, Miryang 627-702, Republic of Korea; 4 Animal Breeding/Genetics and Physiology Division, Animal and Dairy Sciences Cluster, University of the Philippines, Los Baños 4031, College, Laguna 4031, Philippines; 5 Swine Science and Technology Center, Gyeongnam National University of Science and Technology, Jinju, Republic of Korea; 6 Bureau of Animal Industry, National Swine and Poultry Research and Development Center, Tiaong, Quezon, Philippines
Providing UMTS connectivity to PlanetLab nodes

Planetlab is widely recognized as being one of the most important Internet-scale testbeds. However, while allowing experimentations involving hundreds of hosts spread all over the world, PlanetLab still suffers of a few significant limitations. One of these limitations is the lack of heterogeneity, in particular in terms of access technologies. In this paper we describe the efforts we made, in the context of the OneLab European project, in order to mitigate this problem. In particular, we describe how we managed to integrate UMTS connectivity into a PlanetLab-based testbed. We illustrate the technical challenges we had to face, the final result we obtained, and present a case study meant to show the utility of having UMTS connectivity available in Planetlab.
Working memory, age and education: A lifespan fMRI study

Ageing is associated with grey matter atrophy and changes in task-related neural activations. This study investigated the effects of age and education on neural activation during a spatial working memory task in 189 participants aged between 20–80 years old, whilst controlling for grey matter density. Age was related to linear decreases in neural activation in task activated areas, and this effect was no longer significant when adjusting for education or accuracy. Age was also related to cubic increases in neural activation in non-task related areas, such as the temporal gyrus, cuneus and cerebellum when adjusting for accuracy and education. These findings support previous lifespan datasets indicating linear age-related decreases in task activation, but non-linear increases in non-task related areas during episodic memory tasks. The findings also support past studies indicating education offers a form of cognitive reserve through providing a form of neural compensation and highlights the need to consider education in ageing studies.
LTG at SemEval-2016 Task 11: Complex Word Identification with Classifier Ensembles

We present the description of the LTG entry in the SemEval-2016 Complex Word Identification (CWI) task, which aimed to develop systems for identifying complex words in English sentences. Our entry focused on the use of contextual language model features and the application of ensemble classification methods. Both of our systems achieved good performance, ranking in 2nd and 3rd place overall in terms of F-Score.
Trade Spill-Overs of Fiscal Policy in the European Union: A Panel Analysis

We explore the international spillovers from fiscal policy shocks via trade in Europe. A fiscal expansion stimulates domestic activity, which leads to more foreign exports and, hence, higher foreign output. To quantify this, we combine a panel VAR model in government spending, net taxes and GDP with a panel trade model. On average, a public spending increase equal to 1% of GDP implies 2.3% more foreign exports over the first two years. The corresponding figure for an equal-size net tax reduction is 0.6%. Both estimates are statistically significant. As far as the effect on foreign activity is concerned, a 1% of GDP spending increase (net tax reduction) in Germany on average raises GDP of trading partners by 0.23% (0.06%) over the first two years. These figures are likely to form lower bounds for the actual effects and suggest that it may be worthwhile to further investigate the benefits from coordinated fiscal expansions (contractions) in response to European-wide cyclical downturns (upswings).
Uniform measure density condition and game regularity for tug-of-war games

We show that a uniform measure density condition implies game regularity for all $2<p<\infty$ in a stochastic game called 'tug-of-war with noise'. The proof utilizes suitable choices of strategies combined with estimates for the associated stopping times and density estimates for the sum of independent and identically distributed random vectors.
LONG-TERM CHANGES OF ZOOBENTHOS BIOMASS IN THE BARENTS SEA

Long-term variability of marine ecosystems has recently become one of the most topical hydrobiological study subjects. Such an interest in the problem can be explained by the lack of strict interpretation of global climatic fluctuations and other related phenomena. It is still not clear what the causes of the local and global ecosystem fluctuations are and whether the influence of the natural factors on biota prevails over the influence of the human factors. Marine macrozoobenthos indicates and integrates long-term environmental changes very well. Most benthic organisms are slow moving and their life cycles are long in comparison to e.g. pelagic organisms. The temperature dependence of the Barents Sea zoobenthos was shown by many researches (Galkin, 1998), but human influence on bottom fauna was considered only as a hypothesis (Denisenko & Denisenko, 1998). The aim of our study was to reveal the long-term temperature and fishery dependence of zoobenthos biomass in the Barents Sea.
Socio-Demographic Predictors of Loneliness Across the Adult Life Span in Portugal

Loneliness, a complex phenomenon, is experienced differently by people under diverse conditions. The factors influencing loneliness are numerous and may vary between cultures. The purpose of this study was to show socio-demographic factors contributing to loneliness in Portugal. The sample consisted of 3,144 participants with a mean age of 46.90 (SD = 22.56) and a range between 15 and 92 years. Loneliness was evaluated with the Revised UCLA Loneliness Scale (Russell, Peplau, & Cutrona, 1980). Age and marital status were significant predictors of loneliness. Loneliness increased with age, and divorced or windowed participants reported higher loneliness than single or married people. As expected, gender did not significantly contribute to loneliness. This work identified vulnerable people who are experiencing a perceived dissatisfaction with their social interactions that needs special attention. These vulnerable groups include the old, divorced and widowed. In particular, policy makers and other experts who work with old persons should promote interventions according to their needs.
Effect of imidacloprid foliar treatment and banana leaf age on Pentalonia nigronervosa (Hemiptera, Aphididae) survival

Abstract Pentalonia nigronervosa, the banana aphid, is the vector of Banana bunchy top virus to banana. This virus is the etiological agent of banana bunchy top disease, a limiting factor in many banana growing regions, including Hawaii, United States. Laboratory bioassays on banana plants were conducted to evaluate the efficacy of imidacloprid (Provado®), to control P. nigronervosa by comparing insect mortality at four different insecticide concentrations (120,60,24, and 12 ppm) over 1 month, and compared effects on the aphids on new emerging, and old leaf material. We found significant differences between treatments and time after treatment. Aphids survived poorly on newer plant growth, regardless of presence or absence of imidacloprid, or time after treatment. Examining the insecticidal effect on old leaves only, we found that the three highest concentration treatments resulted in high mortality over the 4‐week‐long period of testing. Our results confirm that imidacloprid foliar application on bananas results in effective control of aphids and does not become systemic within the plant. From these results, it is likely that management of banana aphid using imidacloprid under field conditions will be effective on old leaves and new leaves that are sprayed, but leaves emerging after sprays will not be completely protected from aphids. Regular scouting for aphids should be implemented in support of imidacloprid applications.
Seasonal dynamics and virus translocation of Grapevine leafroll-associated virus 3 in grapevine cultivars

Grapevine leafroll-associated virus 3 (GLRaV-3) is associated with grapevine leafroll disease, one of the most economically important viral diseases of grapevines. This disease impacts on both vine health and grape quality; reduction in yield, brix and wine colour are among its detrimental effects. Many methods, including serological and molecular procedures, have been developed for the detection of GLRaV-3; however, there is no PCR-based assay available to quantify virus populations within plant tissues. A real-time RT-PCR assay with TaqMan probe was developed for speciﬁc and reliable quantitative detection of GLRaV-3 in infected tissues. The designed primers and probes target the conserved sequence in the RNA-depen-dent RNA polymerase (RdRp) domain of the viral genome to prevent ampliﬁcation of most subgenomic and defective RNAs. This protocol was used to examine the seasonal dynamics and translocation of GLRaV-3 in ﬁeld-grown grapevines. The results showed that the virus spread quickly from trunks to new growing shoots and leaves early in the growing season, and most samples still harboured detectable virus during late summer and autumn. The seasonal progress of one GLRaV-3 isolate was compared in four grapevine cultivars (Chardonnay, Cabernet Sauvignon, Italia and Thompson Seedless). Within cultivars there was little variability in the distribution and translocation of GLRaV-3, except for in Thompson Seedless. This quantitative detection assay will be a valuable tool for GLRaV-3 diagnosis, disease monitoring and population ecology studies.
Post-Newtonian corrections to the gravitational-wave memory for quasicircular, inspiralling compact binaries

The Christodoulou memory is a nonlinear contribution to the gravitational-wave field that is sourced by the gravitational-wave stress-energy tensor. For quasicircular, inspiralling binaries, the Christodoulou memory produces a growing, nonoscillatory change in the gravitational-wave 'plus' polarization, resulting in the permanent displacement of a pair of freely-falling test masses after the wave has passed. In addition to its nonoscillatory behavior, the Christodoulou memory is interesting because even though it originates from 2.5 post-Newtonian (PN) order multipole interactions, it affects the waveform at leading (Newtonian/quadrupole) order. The memory is also potentially detectable in binary black-hole mergers. While the oscillatory pieces of the gravitational-wave polarizations for quasicircular, inspiralling compact binaries have been computed to 3PN order, the memory contribution to the polarizations has only been calculated to leading order (the next-to-leading order 0.5PN term has previously been shown to vanish). Here the calculation of the memory for quasicircular, inspiralling binaries is extended to 3PN order. While the angular dependence of the memory remains qualitatively unchanged, the PN correction terms tend to reduce the memory's magnitude. Explicit expressions are given for the memory contributions to the plus polarization and the spin-weighted spherical-harmonic modes of the metric and curvature perturbations. Combined with the recent resultsmore » of Blanchet et al.[Classical Quantum Gravity 25, 165003 (2008)], this completes the waveform polarizations to 3PN order. This paper also discusses: (i) the difficulties in extracting the memory from numerical relativity simulations, (ii) other nonoscillatory effects that enter the waveform polarizations at high PN orders, and (iii) issues concerning the observability of the memory in gravitational-wave detectors. « less
Hydrogen sulfide plasma passivation of gallium arsenide

Improvement in the electrical properties of the GaAs surface has been accomplished using a room‐temperature hydrogen sulfide plasma. The surface has then been protected by a 300 °C plasma enhanced chemical vapor deposition (PECVD) SiO2 film. This treatment is highly reproducible due to computer control of process parameters and long‐lasting due to the SiO2 cap. Improved C‐V characteristics were observed, showing interface trap densities in the high 1011 cm−2 eV−1 range. Photoluminescence (PL) measurements on the sulfided samples showed increased intensity over the untreated samples.
Platelet-to-lymphocyte ratio: A new inflammatory marker for the diagnosis of preterm premature rupture of membranes

Objective: Preterm premature rupture of membranes (PPROM) is closely related with maternal and fetal complications. Therefore, early diagnosis is extremely important to provide maternal and fetal well-being. Many inflammatory markers have been evaluated for their ability to diagnose membrane rupture at early stages. We aimed to investigate the relationship between the platelet-to-lymphocyte ratio (PLR) and preterm premature membrane rupture. Material and Methods: In this study, 121 pregnant women with PPROM and 96 age-matched pregnant women with spontaneous preterm labor who were admitted to our hospital between January 2014 and December 2015 were enrolled. Demographic data, complete blood cell count results, and neonatal outcomes were recorded. Results: The neutrophil and platelet counts were higher in the PPROM group (9948.4±3393.2 vs. 7466.1±1698.5/mm3 and 244.5±60 vs. 210.6±64.8/mm3, respectively, p<0.001). The PLR and neutrophil-to-lymphocyte ratios (NLR) were both significantly higher in the PPROM group (p<0.001). Correlation analysis revealed that the PLR was positively correlated with the NLR (r=0.10, p=0.031). The ability of the PLR to diagnose preterm premature rupture of membranes was evaluated using an ROC curve. The sensitivity and specificity of the PLR was 57.8% and 73.7%, respectively, at a threshold >117.14 (p<0.001). Conclusion: The PLR might be a cost effective, easy to use, and practical marker for the early diagnosis of PPROM, which can help to determine the appropriate waiting time for delivery and provide maternal and fetal well-being.
A MOSUM procedure for the estimation of multiple random change points

In this work, we investigate statistical properties of change point estimators based on moving sum statistics. We extend results for testing in a classical situation with multiple deterministic change points by allowing for random exogenous change points that arise in Hidden Markov or regime switching models among others. To this end, we consider a multiple mean change model with possible time series errors and prove that the number and location of change points are estimated consistently by this procedure. Additionally, we derive rates of convergence for the estimation of the location of the change points and show that these rates are strict by deriving the limit distribution of properly scaled estimators. Because the small sample behavior depends crucially on how the asymptotic (long-run) variance of the error sequence is estimated, we propose to use moving sum type estimators for the (long-run) variance and derive their asymptotic properties. While they do not estimate the variance consistently at every point in time, they can still be used to consistently estimate the number and location of the changes. In fact, this inconsistency can even lead to more precise estimators for the change points. Finally, some simulations illustrate the behavior of the estimators in small samples showing that its performance is very good compared to existing methods.
Biotin Attachment Domain-Containing Proteins Irreversibly Inhibit Acetyl CoA Carboxylase1[OPEN]

Biotin attachment domain-containing proteins contribute to irreversible inhibition of ACCase under normal growth conditions and under conditions of fatty acid oversupply in Arabidopsis thaliana. The first committed step in fatty acid synthesis is mediated by acetyl-CoA carboxylase (ACCase), a biotin-dependent enzyme that carboxylates acetyl-CoA to produce malonyl-CoA. ACCase can be feedback regulated by short-term or long-term exposure to fatty acids in the form of Tween 80 (predominantly containing oleic acid), which results in reversible or irreversible ACCase inhibition, respectively. Biotin attachment domain-containing (BADC) proteins are inactive analogs of biotin carboxyl transfer proteins that lack biotin, and their incorporation into ACCase down-regulates its activity by displacing active (biotin-containing) biotin carboxyltransferase protein subunits. Arabidopsis (Arabidopsis thaliana) lines containing T-DNA insertions in BADC1, BADC2, and BADC3 were used to generate badc1 badc2 and badc1 badc3 double mutants. The badc1 badc3 mutant exhibited normal growth and development; however, ACCase activity was 26% higher in badc1 badc3 and its seeds contained 30.1% more fatty acids and 32.6% more triacylgycerol relative to wild-type plants. To assess whether BADC contributes to the irreversible phase of ACCase inhibition, cell suspension cultures were generated from the leaves of badc1 badc3 and wild-type plants and treated with 10 mm Tween 80. Reversible ACCase inhibition was similar in badc1 badc3 and wild-type cultures after 2 d of Tween 80 treatment, but irreversible inhibition was reduced by 50% in badc1 badc3 relative to wild-type plants following 4 d of Tween 80 treatment. In this study, we present evidence for two important homeostatic roles for BADC proteins in down-regulating ACCase activity: by acting during normal growth and development and by contributing to its long-term irreversible feedback inhibition resulting from the oversupply of fatty acids.