Miracle-dz/UniFAR-FTUs huggingface dataset:
Out of order floating point coprocessor for RISC V ISA

Floating point operations are important and essential part of many scientific and engineering applications. Floating point coprocessor (FPU) performs operations like addition, subtraction, division, square root, multiplication, fused multiply and accumulate and compare. Floating point operations are part of ARM, MIPS, and RISC-V etc. instruction sets. The FPU can be a part of hardware or be implemented in software. This paper details an architectural exploration for floating point coprocessor enabled with RISC-V [1] floating point instructions. The Floating unit that has been designed with RISC-V floating point instructions is fully compatible with IEEE 754-2008 standard as well. The floating point coprocessor is capable of handling both single and double precision floating point data operands in out-of-order for execution and in-order commit. The front end of the floating point processor accepts three data operands, rounding mode and associated Opcode fields for decoding. Each floating point operation is tagged with an instruction token for in-order completion and commit. The output of the floating point unit is tagged with either single or double precision results along with floating point exceptions, if any, based on the RISC-V instruction set. The coprocessor for floating point integrates with integer pipeline. The proposed architecture for floating point coprocessor with out-of-order execution, in-order commit and completion/retire has been synthesized, tested and verified on Xilinx Virtex 6 xc6vlx550t-2ff1759 FPGA. A system frequency of 240MHz for single precision floating point and 180 MHz double precision floating point operations has been observed on FPGA.
Rethinking the Validity of Interviews for Employment Decision Making: Implications of Recent Developments in Meta-Analysis

(Book Chapter) Oh, I. -S. , Postlethwaite, B. E. , & Schmidt, F. L. (2013). Rethinking the validity of interviews for employment decision making: Implications of recent developments in meta-analysis (Chapter 12, pp. 297-329). In D. J. Svyantek & K. Mahoney (Eds.), Received wisdom, kernels of truth, and boundary conditions in organizational studies. Charlotte, NC: Information Age Publishing.
Multisystemic Treatment of Antisocial Behavior in Children and Adolescents

Part I: Introduction. Empirical, Conceptual, and Philosophical Bases of MST. Clinical Foundations of MST: Nine Treatment Principles, Home-Based Model of Service Delivery, and Guidelines for Clinical Supervision Part II: Clinical Procedures Assessment of Family Functioning. Family Interventions. Changing Relations with Peers. Promoting Academic and Social Competence in School Settings. When and How to Conduct Individually Oriented Interventions. Family Linkages with Community Supports Part III: Outcomes and Policy. Outcomes of MST: Findings from Controlled Evaluations Epilogue: Policy Implications of the Effectiveness of MST.
Abdominal imaging with a modular combination of spin and gradient echoes

MR‐CAT (combined acquisition technique), a modular hybrid imaging concept, was introduced recently. In this article it is demonstrated that the CAT principles can be applied to form a versatile combination of spin and gradient echoes for abdominal imaging. This CAT approach, which essentially integrates RARE and EPI modules in a sequential fashion, was used to implement a set of segmented and single‐shot RARE/EPI‐CAT imaging techniques. CAT was used in in vivo studies to perform high‐resolution abdominal imaging in five healthy subjects. The results demonstrate the feasibility of abdominal imaging using the proposed CAT approach and the potential of this technique to reduce imaging time while preserving image quality. Magn Reson Med 47:425–432, 2002. © 2002 Wiley‐Liss, Inc.
Activation of TRPV1 by the Satiety Factor Oleoylethanolamide*

The fatty acid oleoylethanolamide (OEA) is a satiety factor that excites peripheral vagal sensory nerves, but the mechanism by which this occurs and the molecular targets of OEA are unclear. In this study the ability of OEA to modulate the capsaicin receptor (TRPV1) was explored. OEA alone did not activate TRPV1 expressed in Xenopus oocytes under control conditions, but produced a differential modulation of agonist-evoked responses. OEA enhanced proton-gated TRPV1 currents, inhibited anandamide-evoked currents and had no effect on capsaicin-evoked responses. Following stimulation of protein kinase C (PKC), OEA alone directly activated TRPV1 channel with an EC50 of ∼2 μm at room temperature. This effect was due to direct phosphorylation of TRPV1 because no responses to OEA were observed with mutant channels lacking critical PKC phosphorylation sites, S502A/S800A. In sensory neurons, OEA-induced Ca2+ rises that were selective for capsaicin-sensitive cells, inhibited by the TRPV1 blocker, capsazepine, and occurred in a PKC-dependent manner. Further, after PKC stimulation, OEA activated TRPV1 channels in cell-free patches suggesting a direct mode of action. Thus, TRPV1 represents a potential target for OEA and may contribute to the excitatory action of OEA on sensory nerves.
Speculative Urbanism and the Making of the Next World City

This article explores the process of making Bangalore, India into a ‘world city’ by focusing on specific world-city projects, the parastatal government agencies managing them, the explosive IT industry as the putative engine behind this world-city making, and the inter-urban dynamics across world cities such as Dubai and Singapore. Most of these activities are linked to the highly remunerative challenge of transforming rural economies into urban real estate. Land speculation and active dispossession of those working and living in the rural periphery, on land upon which the new world-city projects are being built, is the main business of government today in Bangalore. This article suggests that this temporary ‘state of exception’, with both its attendant suspensions of civil and human rights as well as their institutionalization into government practices, reflects a shift into new forms of ‘speculative’ government, economy, urbanism and citizenship.
A fatal neuromuscular disease in an adult patient after poliomyelitis in early childhood: Consideration of the pathology of post‐polio syndrome

Post‐polio syndrome (PPS) characterized by new neuromuscular problems can appear many years after acute poliomyelitis in polio survivors. We report a 77‐year‐old man with antecedent poliomyelitis who newly developed neuromuscular disease with a clinical course of 27 years, the final 10 years of which were characterized by apparent progression, thus raising doubt as to the clinical diagnosis of amyotrophic lateral sclerosis (ALS) following PPS. Pathologically, plaque‐like, old poliomyelitis lesions were found almost exclusively in the lumbosacral cord, showing complete neuronal loss and glial scars in the anterior horns. Although less severe, neuronal loss and gliosis were also evident outside the old lesions, including the intermediate zone. Moreover, symmetrical degeneration of the corticospinal tracts, as evidenced by CD68 immunostaining, was a feature of the white matter of the lower spinal cord. In the motor cortex, loss of Betz cells was also confirmed. Synaptophysin immunostaining of the lumbosacral cord also revealed decreased expression outside the old lesions, excluding the posterior horn. Interestingly, decreased expression of synaptophysin was also evident in the cervical anterior horns, where no old lesions were observed. No Bunina bodies, TDP‐43 inclusions, or Golgi fragmentation were found. Neurogenic atrophy was evident in the iliopsoas and scalenus muscles, and inclusion body myositis‐like changes were also observed in these muscles and the tongue. Was it possible to have diagnosed this patient as having ALS? We consider that the features in this case may have represented the pathology of long‐standing and/or fatal PPS itself, and not ALS.
What is the effect of yoga compared to a physical education class on stress reactivity for sixth-grade students?

ed by Stephanie Marraffa, a student in the Health and Exercise Science Teaching Program at The College of New Jersey in Ewing, NJ. What Was the Question? This study was interested in the physiological responses of children to stressful stimuli or stress reactivity. As the authors noted, stress reactivity in children has been related to important health factors such as hypertension, future blood pressure status, levels of adiposity, and the ability to regulate emotions. While controlled studies have shown improved levels of stress in children who practice yoga, few studies have examined yoga within the context of school, and none have utilized physiological measures to gauge stress reactivity.
Comparison of Lateral Locking Plate and Antiglide Plate for Fixation of Distal Fibular Fractures in Osteoporotic Bone: A Biomechanical Study

Objectives: The purpose of this study was to compare the biomechanical properties of posterolateral antiglide plating and lateral locked plating for fixation of displaced short oblique fractures of the fibula in osteoporotic bone. Methods: Short oblique fractures of the distal fibula at the level of the syndesmosis were simulated with a fibular osteotomy and ligamentous sectioning in 18 paired fresh frozen ankles. The fractures were fixed with either a lateral locking plate with an independent lag screw or a posterolateral antiglide plate with a lag screw through the plate. The specimens were tested under a torsional load to failure. The torque to failure, angular rotation at failure, and construct stiffness of the two groups were compared. Results: The torque to failure and construct stiffness were significantly greater on the side with the posterolateral antiglide plate than on the side with the the lateral locking plate (P = 0.01 and 0.005, respectively). Conclusions: The posterolateral antiglide plate demonstrated improved biomechanical stability as compared to the lateral locking plate in osteoporotic bone. In situations where fixation needs to be optimized, use of an antiglide plate may be favored over a lateral locking plate construct.
The Blackwell companion to social movements

32.03 MB Free download The Blackwell Companion to Social Movements book PDF, FB2, EPUB and MOBI. Read online The Blackwell Companion to Social Movements which classified as Other that has 776 pages that contain constructive material with lovely reading experience. Reading online The Blackwell Companion to Social Movements book will be provide using wonderful book reader and it's might gives you some access to identifying the book content before you download the book.
On Applications of a Generalized Hyperbolic Measure of Entropy

After generalization of Shannon's entropy measure by Renyi in 1961, many generalized versions of Shannon measure were proposed by different authors. Shannon measure can be obtained from these generalized measures asymptotically. A natural question arises in the parametric generalization of Shannon's entropy measure. What is the role of the parameter(s) from application point of view? In the present communication, super additivity and fast scalability of generalized hyperbolic measure (Bhatia and Singh, 2013) of probabilistic entropy as compared to some classical measures of entropy has been shown. Application of a generalized hyperbolic measure of probabilistic entropy in certain situations has been discussed. Also, application of generalized hyperbolic measure of fuzzy entropy in multi attribute decision making have been presented where the parameter affects the preference order. i i i i i p p E Inf p P H       
Single paracostal approach to thoracic duct and cisterna chyli: experimental study and case series.

OBJECTIVE To-determine the feasibility of a single paracostal abdominal approach for thoracic duct ligation (TDL) and cisterna chyli ablation (CCA) in dogs with chylothorax. STUDY DESIGN Observational study and prospective case series. ANIMALS Normal dogs (n = 5) and dogs with chylothorax (n = 8). METHODS A single paracostal approach with transdiaphragmatic extension for TDL and CCA was developed experimentally (n = 5) and used in 8 clinical cases with subtotal pericardectomy (SPE) performed in 4 dogs. Surgery time, complications, hospitalization time, outcome, and follow-up of clinical cases were recorded. RESULTS Exposure of relevant anatomy was excellent; vital lymphatic staining facilitated identification of lymphatic structures. In clinical cases, mean surgery time for TDL + CCA was 136 minutes. Mean hospitalization time was 3.1 days. Seven of 8 cases survived, with 1 dog dying of heart failure shortly after discharge. One dog required a second (left) paracostal approach to ligate 2 more lymphatic vessels. On follow-up (median, 7 months; range, 2-20 months), there was complete resolution of chylothorax in 6 dogs. CONCLUSIONS A single paracostal approach provides excellent exposure of cisterna chyli, caudal thoracic duct, and intestinal lymphatics. This approach eliminates the need for repositioning during combined TDL + CCA procedures and avoids an intercostal thoracotomy.
Life Situations, Emotions, and Extrasystoles

The occurrence of cardiac arrhythmias in asso- ciation with emotional stress is a common clinical observation (2,6,8,13,14). To explore the validity of the inference that such extrasystoles occur as part of the organism's reaction to life situations, a sys- tematic study was made of 12 unselected patients displaying extrasystoles. In most of these patients palpitation was the presenting complaint; in a few it was an incidental finding. In 5 of the subjects other arrhythmias occurred as well. In all instances a detailed history was obtained; a complete physical examination and indicated laboratory precedures were performed to determine the presence and nature of any functional or structural heart disease or other abnormality. A series of interviews was conducted over varying lengths of time up to one year and totalling up to forty hours, during which a life history and personality study were obtained. An evaluation was also made of the current life situation and the emotional responses thereto. As the patient was followed de- tailed inquiries were made into the circumstances of each episode of arrhythmia. Among these, such factors as exercise, infection, tobacco, alcohol, and coffee were carefully noted as well as attitudes, feeling states, and life situations. Every effort was made to distinguish the influence of the former group of factors from that of the latter group. In addition to the day to day observations of these subjects, attempts were made to determine under what controlled circumstances arrhythmias might occur. The subjects were taken to a quiet room where they lay on a comfortable bed and where extraneous disturbing factors were kept at a minimum. Frequent intermittent recordings were made from a direct-writing electrocardiogram, while the patients were interviewed by a physician —usually over a period of about an hour. At times the interview was directed towards topics to which the patient was known to be sensitive or events which had previously been associated with the
Euclidean Distance Matrices: Essential theory, algorithms, and applications

Euclidean distance matrices (EDMs) are matrices of the squared distances between points. The definition is deceivingly simple; thanks to their many useful properties, they have found applications in psychometrics, crystallography, machine learning, wireless sensor networks, acoustics, and more. Despite the usefulness of EDMs, they seem to be insufficiently known in the signal processing community. Our goal is to rectify this mishap in a concise tutorial. We review the fundamental properties of EDMs, such as rank or (non)definiteness, and show how the various EDM properties can be used to design algorithms for completing and denoising distance data. Along the way, we demonstrate applications to microphone position calibration, ultrasound tomography, room reconstruction from echoes, and phase retrieval. By spelling out the essential algorithms, we hope to fast-track the readers in applying EDMs to their own problems. The code for all of the described algorithms and to generate the figures in the article is available online at http://lcav.epfl. ch/ivan.dokmanic. Finally, we suggest directions for further research.
Reviving Hedonism about Well-Being: Refuting the Argument from False Pleasures and 
Restricting the Relevance of Intuitive 'Evidence'

Throughout the vast majority of its history, hedonism about well-being has been perennially unpopular (Feldman 2004). The arguments in this essay take steps towards reviving the plausibility of hedonism about well-being. The main argument currently used to refute hedonism about well-being, the Argument from False Pleasures, is shown to lack sufficient evidence to be compelling. The main evidence provided for the Argument from False Pleasures comes in the form of two thought experiments, the Experience Machine (Nozick 1974) and the Deceived Businessman (Kagan 1998). These thought experiments typically produce strong intuitive responses, which are used to directly support the Argument from False Pleasures. This essay investigates how theories of well-being are currently evaluated by moral philosophers, with a specific focus on the place our intuitions have in the process. Indeed, the major role that moral intuitions play in evaluating theories of well-being, despite their sometimes dubious epistemic credentials, leads to an in-depth enquiry into their inner workings and potential for containing normatively significant information. The investigation, which draws on the work of Woodward and Allman (2007), concludes that intuitions about unrealistic thought experiments should not play an important role in evaluating theories of well-being. Rather, they should only act as a warning sign, highlighting moral propositions for further analysis. Based on these findings, a new method for assessing theories of well-being is suggested and applied to a specific internalist account of hedonism about well-being to show how the Deceived Businessman and Experience Machine thought experiments lack normative significance, leaving the Argument from False Pleasures without sufficient evidence to be compelling. Indeed, this essay concludes that the Argument from False Pleasures should no longer be thought to provide any good reason to believe that hedonism about well-being is implausible. This result is only one step on the road to reviving hedonism about well-being, but it is a very important one.
Nitrate Sensing and Metabolism Inhibit Biofilm Formation in the Opportunistic Pathogen Burkholderia pseudomallei by Reducing the Intracellular Concentration of c-di-GMP

The opportunistic pathogen Burkholderia pseudomallei is a saprophytic bacterium and the causative agent of melioidosis, an emerging infectious disease associated with high morbidity and mortality. Although melioidosis is most prevalent during the rainy season in endemic areas, domestic gardens and farms can also serve as a reservoir for B. pseudomallei during the dry season, in part due to irrigation and fertilizer use. In the environment, B. pseudomallei forms biofilms and persists in soil near plant root zones. Biofilms are dynamic bacterial communities whose formation is regulated by extracellular cues and corresponding changes in the nearly universal secondary messenger cyclic dimeric GMP. Recent studies suggest B. pseudomallei loads are increased by irrigation and the addition of nitrate-rich fertilizers, whereby such nutrient imbalances may be linked to the transmission epidemiology of this important pathogen. We hypothesized that exogenous nitrate inhibits B. pseudomallei biofilms by reducing the intracellular concentration of c-di-GMP. Bioinformatics analyses revealed B. pseudomallei 1026b has the coding capacity for nitrate sensing, metabolism, and transport distributed on both chromosomes. Using a sequence-defined library of B. pseudomallei 1026b transposon insertion mutants, we characterized the role of denitrification genes in biofilm formation in response to nitrate. Our results indicate that the denitrification pathway is implicated in B. pseudomallei biofilm growth dynamics and biofilm formation is inhibited by exogenous addition of sodium nitrate. Genomics analysis identified transposon insertional mutants in a predicted two-component system (narX/narL), a nitrate reductase (narGH), and a nitrate transporter (narK-1) required to sense nitrate and alter biofilm formation. Additionally, the results presented here show that exogenous nitrate reduces intracellular levels of the bacterial second messenger c-di-GMP. These results implicate the role of nitrate sensing in the regulation of a c-di-GMP phosphodiesterase and the corresponding effects on c-di-GMP levels and biofilm formation in B. pseudomallei 1026b.
2‐methoxyestradiol blocks cell‐cycle progression at G2/M phase and inhibits growth of human prostate cancer cells

2‐Methoxyestradiol (2‐ME), an endogenous metabolite of 17β‐estradiol, is present in human blood and urine. Here we show for the first time that 2‐ME significantly inhibited the growth of normal prostate epithelial cells and androgen‐dependent LNCaP and androgen‐independent DU145 prostate cancer cells. This growth inhibition was accompanied by a twofold increase in the G2/M population, with a concomitant decrease in the G1 population, as shown by cell‐cycle analysis. 2‐ME treatment affected the cell‐cycle progression of prostate cancer cells specifically by blocking cells in the G2 phase. Immunoblot analysis of the key cell‐cycle regulatory proteins in the G2/M phase showed a 14‐fold increase in the expression of p21 and an eightfold increase in the expression of p34 cell division cycle 2 (cdc2). We also found an accumulation of phosphorylated cdc2 after 2‐ME treatment. Furthermore, Wee 1 kinase was detectable after 2‐ME treatment. 2‐ME treatment also led to an increase in the activity of caspase‐3, followed by apoptosis, as shown by terminal deoxynucleotidyl transferase–mediated deoxyuridine 5‐triphosphate–biotin nick end‐labeling and fluorescein isothiocyanate–poly(ADP‐ribose) polymerase assay. Estrogen receptor levels did not change after treatment with 2‐ME. Examination of the signaling pathways that mediate 2‐ME–induced apoptosis showed reduction in the level of p53 expression and its DNA‐binding activity. Given the fact that p53 mutations are common in patients with metastatic prostate cancer, our finding that 2‐ME–mediated growth inhibition of human prostate cancer cells occurred in a p53‐independent manner has considerable clinical significance. These findings, combined with the limited toxicity of 2‐ME, may have significant implications for alternative treatment of advanced prostate cancer. © 2001 Wiley‐Liss, Inc.
Cultural Congruence, Strength, and Type: Relationships to Effectiveness

Organizational effectiveness was studied, based on questionnaire responses by 3,406 administrators, faculty department heads, and trustees from 334 colleges and universities. The extent to which four cultures (clan, adhocracy, hierarchy, or market cultures) were dominant on campus was examined. (ERIC ED 627, 52 PP, MF $.97, PC $7.14).