Miracle-dz/UniFAR-FTUs huggingface dataset:
The cognitive profile

This handbook describes the development of a psychometric assessment tool, and how a group of staff adapted it to make a meaningful advisory tool for people with dementia and their families. It has been written by the Cog-Pro Development Group, which consists of many of the staff involved in the development of the Cog-Pro. [from Dementia Voice website www.dementia-voice.org. uk/Publications.htm] Accessed 05/07/06
Buffering acculturative stress and facilitating cultural adaptation: nostalgia as a psychological resource

Immigration and migration, albeit a steady force throughout human history, are reaching unprecedented proportions. There were 191 million immigrants in 2005, projected to reach 350 million by the year 2025 (United Nations, 2002, 2006). Adding to this statistic are the short-term migrants: assorted sojourners or expatriates, approximately one million international students each year (Open Doors, 1996/1997), and 874 million tourists in 2005, projected to reach 1.6 billion by 2020 (United Nations World Tourism Organization, 2006, 2008). Our focus in this chapter is on immigrants, although our discussion is also relevant to migrants— especially sojourners, expatriates, and international students. We first discuss the negative experiences or stressors facing immigrants as they strive to adjust in their host country (also referred to as recipient society or society of settlement). We proceed with a consideration of a crucial psychological consequence of these stressors: acculturative stress. Next, we introduce the construct of nostalgia, elaborate on its properties and triggers, and highlight its functions as a psychological resource. In the ensuing section, we offer and develop the central claim of this chapter. Specifically, we emphasize the role of nostalgia as a coping strategy for alleviating acculturative stress and for contributing to successful acculturation patterns (e.g., integration).
Individual Improvisation in Information Systems Development

Improvisation is rapidly becoming an important issue for both scholars and practitioners. Organizations that operate in turbulent environments must learn to swiftly adapt and respond to such instability, especially in areas as innovation and new product development. In such contexts, traditional top-down, carefully-planned approaches to innovative projects may represent an obstacle to effectively dealing with environment uncertainty. Prior research on improvisation has focused considerable attention on the centrality of improvisation in individual and group outcomes, while less emphasis has been placed on how individual attitude toward improvisation is formed. In an attempt to fill this gap, we will theoretically analyze the antecedents of individual attitude toward improvisation, by looking at the information systems development (ISD) domain. In particular, the outcome of this chapter is the development of theoretical propositions which could be empirically tested in future research.
StereoBrush: interactive 2D to 3D conversion using discontinuous warps

We introduce a novel workflow for stereoscopic 2D to 3D conversion in which the user "paints" depth onto a 2D image via sparse scribbles, instantaneously receiving intuitive 3D feedback. This workflow is enabled by the introduction of a discontinuous warping technique that creates stereoscopic pairs from sparse, possibly erroneous user input. Our method assumes a piecewise continuous depth representation, preserving visual continuity in most areas, while creating sharp depth discontinuities at important object boundaries. As opposed to prior work that relies strictly on a per pixel depth map, our scribbles are processed as soft constraints in a global solve and operate entirely on image domain disparity, allowing for relaxed input requirements. This formulation also allows us to simultaneously compute a disparity-and-content-aware stretching of background areas to automatically fill disoccluded regions with valid stereo information. We tightly integrate all steps of stereo content conversion into a single optimization framework, which can then be solved on a GPU at interactive rates. The instant feedback received while painting depth allows even untrained users to quickly create compelling 3D scenes from single-view footage.
A pilot examination of the genome-wide DNA methylation signatures of subjects entering and exiting short-term alcohol dependence treatment programs

Alcoholism has a profound impact on millions of people throughout the world. However, the ability to determine if a patient needs treatment is hindered by reliance on self-reporting and the clinician’s capability to monitor the patient’s response to treatment is challenged by the lack of reliable biomarkers. Using a genome-wide approach, we have previously shown that chronic alcohol use is associated with methylation changes in DNA from human cell lines. In this pilot study, we now examine DNA methylation in peripheral mononuclear cell DNA gathered from subjects as they enter and leave short-term alcohol treatment. When compared with abstinent controls, subjects with heavy alcohol use show widespread changes in DNA methylation that have a tendency to reverse with abstinence. Pathway analysis demonstrates that these changes map to gene networks involved in apoptosis. There is no significant overlap of the alcohol signature with the methylation signature previously derived for smoking. We conclude that DNA methylation may have future clinical utility in assessing acute alcohol use status and monitoring treatment response.
Early Developmental Low-Dose Methylmercury Exposure Alters Learning and Memory in Periadolescent but Not Young Adult Rats

Few studies have assessed the effects of developmental methylmercury (MeHg) exposure on learning and memory at different ages. The possibility of the amelioration or worsening of the effects has not been sufficiently investigated. This study aimed to assess whether low-dose MeHg exposure in utero and during suckling induces differential disturbances in learning and memory of periadolescent and young adult rats. Four experimental groups of pregnant Sprague-Dawley rats were orally exposed to MeHg or vehicle from gestational day 5 to weaning: (1) control (vehicle), (2) 250 μg/kg/day MeHg, (3) 500 μg/kg/day MeHg, and (4) vehicle, and treated on the test day with MK-801 (0.15 mg/kg i.p.), an antagonist of the N-methyl D-aspartate receptor. The effects were evaluated in male offspring through the open field test, object recognition test, Morris water maze, and conditioned taste aversion. For each test and stage assessed, different groups of animals were used. MeHg exposure, in a dose-dependent manner, disrupted exploratory behaviour, recognition memory, spatial learning, and acquisition of aversive memories in periadolescent rats, but alterations were not observed in littermates tested in young adulthood. These results suggest that developmental low-dose exposure to MeHg induces age-dependent detrimental effects. The relevance of decreasing exposure to MeHg in humans remains to be determined.
A NEW MULTI-DIMENSIONAL GENERAL RELATIVISTIC NEUTRINO HYDRODYNAMICS CODE OF CORE-COLLAPSE SUPERNOVAE. III. GRAVITATIONAL WAVE SIGNALS FROM SUPERNOVA EXPLOSION MODELS

We present a detailed theoretical analysis of the gravitational wave (GW) signal of the post-bounce evolution of core-collapse supernovae (SNe), employing for the first time relativistic, two-dimensional explosion models with multi-group, three-flavor neutrino transport based on the ray-by-ray-plus approximation. The waveforms reflect the accelerated mass motions associated with the characteristic evolutionary stages that were also identified in previous works: a quasi-periodic modulation by prompt post-shock convection is followed by a phase of relative quiescence before growing amplitudes signal violent hydrodynamical activity due to convection and the standing accretion shock instability during the accretion period of the stalled shock. Finally, a high-frequency, low-amplitude variation from proto-neutron star (PNS) convection below the neutrinosphere appears superimposed on the low-frequency trend associated with the aspherical expansion of the SN shock after the onset of the explosion. Relativistic effects in combination with detailed neutrino transport are shown to be essential for quantitative predictions of the GW frequency evolution and energy spectrum, because they determine the structure of the PNS surface layer and its characteristic g-mode frequency. Burst-like high-frequency activity phases, correlated with sudden luminosity increase and spectral hardening of electron (anti-)neutrino emission for some 10 ms, are discovered as new features after the onset of the explosion. They correspond to intermittent episodes of anisotropic accretion by the PNS in the case of fallback SNe. We find stronger signals for more massive progenitors with large accretion rates. The typical frequencies are higher for massive PNSs, though the time-integrated spectrum also strongly depends on the model dynamics.
Quantitative Assessment of Chronic Thalamic Stroke

SUMMARY: The procedure presented quantitatively assesses thalamic lesions in the chronic phase of an ischemic episode. The structural MR images of 19 patients with ischemia in the thalamus were assessed by radiologic inspection. An independent rater allocated the damage to the thalamic nuclei. The assessments showed 89% accordance with the radiologic inspection (P < .001). This procedure ranks the extent of the damage to thalamic nuclei and accounts for postacute rearrangement of the neural tissue.
Effects of Epicardial and Endocardial Cardiac Resynchronization Therapy on Coronary Flow: Insights From Wave Intensity Analysis

Background The increase in global coronary flow seen with conventional biventricular pacing is mediated by an increase in the dominant backward expansion wave (BEW). Little is known about the determinants of flow in the left‐sided epicardial coronary arteries beyond this or the effect of endocardial pacing stimulation on coronary physiology. Methods and Results Eleven patients with a chronically implanted biventricular pacemaker underwent an acute hemodynamic and electrophysiological study. Five of 11 patients also took part in a left ventricular endocardial pacing protocol at the same time. Conventional biventricular pacing, delivered epicardially from the coronary sinus, resulted in a 9% increase in flow (average peak velocity) in the left anterior descending artery (LAD), mediated by a 13% increase in the area under the BEW (P=0.004). Endocardial pacing resulted in a 27% increase in LAD flow, mediated by a 112% increase in the area under the forward compression wave (FCW) and a 43% increase in the area under the BEW (P=0.048 and P=0.036, respectively). There were no significant changes in circumflex parameters. Conventional biventricular pacing resulted in homogenization of timing of coronary flow compared with baseline (mean difference in time to peak in the LAD versus circumflex artery: FCW 39 ms [baseline] versus 3 ms [conventional biventricular pacing], P=0.008; BEW 47 ms [baseline] versus 8 ms [conventional biventricular pacing], P=0.004). Conclusions Epicardial and endocardial pacing result in increased coronary flow in the left anterior descending artery and homogenization of the timing of waves that determine flow in the LAD and the circumflex artery. The increase in both the FCW and the BEW with endocardial pacing may be the result of a more physiological activation pattern than that of epicardial pacing, which resulted in an increase of only the BEW.
Assessment of Toluene/Biphenyl Dioxygenase Gene Diversity in Benzene-Polluted Soils: Links between Benzene Biodegradation and Genes Similar to Those Encoding Isopropylbenzene Dioxygenases

ABSTRACT The PCR-single-strand conformation polymorphism (SSCP) technique was used to assess the diversity and distribution of Rieske nonheme iron oxygenases of the toluene/biphenyl subfamily in soil DNA and bacterial isolates recovered from sites contaminated with benzene, toluene, ethylbenzene, and xylenes (BTEX). The central cores of genes encoding the catalytic α subunits were targeted, since they are responsible for the substrate specificities of these enzymes. SSCP functional genotype fingerprinting revealed a substantial diversity of oxygenase genes in three differently BTEX-contaminated soil samples, and sequence analysis indicated that in both the soil DNA and the bacterial isolates, genes for oxygenases related to the isopropylbenzene (cumene) dioxygenase branch of the toluene/biphenyl oxygenase subfamily were predominant among the detectable genotypes. The peptide sequences of the two most abundant α subunit sequence types differed by only five amino acids (residues 258, 286, 288, 289, and 321 according to numbering in cumene dioxygenase α subunit CumA1 of Pseudomonas fluorescens IP01). However, a strong correlation between sequence type and substrate utilization pattern was observed in isolates harboring these genes. Two of these residues were located at positions contributing, according to the resolved crystal structure of cumene dioxygenase from Pseudomonas fluorescens IP01, to the inner surface of the substrate-binding pocket. Isolates containing an α subunit with isoleucine and leucine at positions 288 and 321, respectively, were capable of degrading benzene and toluene, whereas isolates containing two methionine substitutions were found to be incapable of degrading toluene, indicating that the more bulky methionine residues significantly narrowed the available space within the substrate-binding pocket.
Does mirtazapine have a more rapid onset than SSRIs?

BACKGROUND A single study utilizing a cross-sectional analysis of scores on the Hamilton Rating Scale for Depression (HAM-D) suggested that mirtazapine has a more rapid onset than selective serotonin reuptake inhibitors (SSRIs). Analysis based on the HAM-D may favor drugs with sleep-producing effects. The purpose of the present study was to determine if a review of all studies comparing an SSRI with mirtazapine, utilizing persistent improvement as the dependent variable, would suggest that mirtazapine had a more rapid onset than SSRIs. METHOD All double-blind studies comparing mirtazapine with SSRIs were analyzed. Included in the analysis to determine speed of onset were 298 patients taking mirtazapine and 285 taking an SSRI. Pattern analysis, which has been described and used by other researchers, was employed to study speed of onset. RESULTS At the end of each of the 3 studies, the total number of responders for each of the drugs did not differ. However, the proportion of responders with onset of persistent improvement in week 1 was greater for mirtazapine (13%, 38/298) than for the SSRIs (6%, 18/285; chi2 = 6.95, df = 1, p = .008). CONCLUSION These data support the possibility that mirtazapine may have a more rapid onset than SSRIs. This observation should be considered preliminary because of the retrospective nature of the analysis and the absence of a placebo group.
Inhibition of angiogenesis by oral ingestion of powdered shark cartilage in a rat model.

INTRODUCTION kawa et al., 1990). However, the links between oral ingestion of cartilage and its anti-angiogenic and anti-tumour properties have yet to be convincingly The oral consumption of dried powdered shark demonstrated. cartilage has been widely promoted as a natural Clinical trials of powdered shark cartilage as an health remedy for the treatment of cancer (Wilson, anti-cancer agent have been initiated in Mexico and 1994; Lane and Comac, 1992, 1996). It is proposed to the United States but the results have yet to be pubact by preventing the angiogenesis required by solid lished. In this study we have examined whether the tumours to grow larger than 2 –3 mm (Folkman, oral ingestion of powdered shark cartilage by rats 1995). has any effect on the angiogenesis induced in mesenThere is some evidence for the presence of antiteric windows by mast cell stimulation. angiogenic factors in shark cartilage. Implantation of polymer pellets containing a shark cartilage extract alongside tumours in rabbit corneas inhibited tuMATERIALS AND METHODS mour neovascularization (Lee and Langer, 1983). Injection of a suspension of shark cartilage reduced angiogenesis in tumours implanted in mice (Cataldi Shark cartilage. Dried powdered samples of cartiand Osbourne, 1995) and anti-angiogenic factors lage from two commercial batches (designated A and could be partially purified from shark cartilage (OiB) manufactured principally from blue shark were supplied by McFarlane Laboratories Ltd. (Auckland, 1 Supported by the New Zealand Foundation of Science, Research New Zealand). and Technology, the New Zealand Lottery Grants Board and the Induced angiogenesis. A modification of the rat Wellington Medical Research Foundation. We thank Mr. John Croft mesenteric-window assay (Norrby et al., 1990) was of McFarlane Laboratories (NZ) Ltd. for providing samples of shark used. Sprague– Dawley rats (6 weeks old, equal numcartilage. 2 To whom correspondence should be addressed. bers of male and female) were assigned to one of
Market Size, Trade, and Productivity

We develop a monopolistically competitive model of trade with firm heterogeneity—in terms of productivity differences—and endogenous differences in the “toughness” of competition across markets—in terms of the number and average productivity of competing firms. We analyse how these features vary across markets of different size that are not perfectly integrated through trade; we then study the effects of different trade liberalization policies. In our model, market size and trade affect the toughness of competition, which then feeds back into the selection of heterogeneous producers and exporters in that market. Aggregate productivity and average mark-ups thus respond to both the size of a market and the extent of its integration through trade (larger, more integrated markets exhibit higher productivity and lower mark-ups). Our model remains highly tractable, even when extended to a general framework with multiple asymmetric countries integrated to different extents through asymmetric trade costs. We believe this provides a useful modelling framework that is particularly well suited to the analysis of trade and regional integration policy scenarios in an environment with heterogeneous firms and endogenous mark-ups.
Have a little faith: measuring the impact of illness on positive and negative aspects of faith

The importance of faith and its associations with health are well documented. As part of the Patient Reported Outcomes Measurement Information System, items tapping positive and negative impact of illness (PII and NII) were developed across four content domains: Coping/Stress Response, Self‐Concept, Social Connection/Isolation, and Meaning and Spirituality. Faith items were included within the concept of meaning and spirituality.
Planck intermediate results - XXVIII. Interstellar gas and dust in the Chamaeleon clouds as seen by Fermi LAT and Planck

The nearby Chamaeleon clouds have been observed in γ rays by the Fermi Large Area Telescope (LAT) and in thermal dust emission by Planck and IRAS. Cosmic rays and large dust grains, if smoothly mixed with gas, can jointly serve with the H i and 12CO radio data to (i) map the hydrogen column densities, NH, in the different gas phases, in particular at the dark neutral medium (DNM) transition between the H i-bright and CO-bright media; (ii) constrain the CO-to-H2 conversion factor, XCO; and (iii) probe the dust properties per gas nucleon in each phase and map their spatial variations across the clouds. We have separated clouds at local, intermediate, and Galactic velocities in H i and 12CO line emission to model in parallel the γ-ray intensity recorded between 0.4 and 100 GeV; the dust optical depth at 353 GHz, τ353; the thermal radiance of the large grains; and an estimate of the dust extinction, AVQ, empirically corrected for the starlight intensity. The dust and γ-ray models have been coupled to account for the DNM gas. The consistent γ-ray emissivity spectra recorded in the different phases confirm that the GeV–TeV cosmic rays probed by the LAT uniformly permeate all gas phases up to the 12CO cores. The dust and cosmic rays both reveal large amounts of DNM gas, with comparable spatial distributions and twice as much mass as in the CO-bright clouds. We give constraints on the H i-DNM-CO transitions for five separate clouds. CO-dark H2 dominates the molecular columns up to AV ≃ 0.9 and its mass often exceeds the one-third of the molecular mass expected by theory. The corrected AVQ extinction largely provides the best fit to the total gas traced by the γ rays. Nevertheless, we find evidence for a marked rise in AVQ/NH with increasing NH and molecular fraction, and with decreasing dust temperature. The rise in τ353/NH is even steeper. We observe variations of lesser amplitude and orderliness for the specific power of the grains, except for a coherent decline by half in the CO cores. This combined information suggests grain evolution. We provide average values for the dust properties per gas nucleon in the different phases. The γ rays and dust radiance yield consistent XCO estimates near 0.7 × 1020 cm-2 K-1 km-1 s. The AVQ and τ353 tracers yield biased values because of the large rise in grain opacity in the CO clouds. These results clarify a recurrent disparity in the γ-ray versus dust calibration of XCO, but they confirm the factor of 2 difference found between the XCO estimates in nearby clouds and in the neighbouring spiral arms.
Interactions of the Vitamin D Receptor with the Corepressor Hairless

Atrichia with papular lesions (APL) and hereditary vitamin D-resistant rickets have a similar congenital hair loss disorder caused by mutations in hairless (HR) and vitamin D receptor (VDR) genes, respectively. HR is a VDR corepressor, and it has been hypothesized that VDR·HR suppress gene expression during specific phases of the hair cycle. In this study, we examined the corepressor activity of HR mutants (E583V, C622G, N970S, V1056M, D1012N, V1136D, and Q1176X) previously described as the molecular cause of APL as well as HR variants (P69S, C397Y, A576V, E591G, R620Q, T1022A) due to non-synonymous polymorphisms in the HR gene. We found that the corepressor activities of all but one of the pathogenic HR mutants were completely abolished. HR mutant E583V exhibited normal corepressor activity, suggesting that it may not be pathogenic. In co-immunoprecipitation assays, all of the pathogenic HR mutants bound VDR but exhibited reduced binding to histone deacetylase 1 (HDAC1), suggesting that the impaired corepressor activity is due in part to defective interactions with HDACs. The HR variants exhibited two classes of corepressor activity, those with normal activity (C397Y, E591G, R620Q) and those with partially reduced activity (P69S, A576V, T1022A). All of the variants interacted with VDR and HDAC1 with the exception of P69S, which was degraded. When coexpressed with VDR, all of the HR pathogenic mutants and variants increased the level of VDR protein, demonstrating that this function of HR was not impaired by these mutations. This study of HR mutations provides evidence for the molecular basis of APL.