Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative Efficacy of the Lederle/Takeda acellular pertussis component DTP (DTaP) vaccine and Lederle whole-cell component DTP vaccine in German children after household exposure. Pertussis Vaccine Study Group.

BACKGROUND A household contact substudy was performed as part of a prospective, cohort pertussis vaccine efficacy trial in Germany. DESIGN Infants received four doses of either the Lederle/Takeda acellular pertussis component diphtheria-tetanus toxoids (DTP) vaccine (DTaP) or Lederle whole-cell component DTP vaccine at 3, 4.5, 6, and 15 to 18 months of age (Wyeth-Lederle Vaccines and Pediatrics, Pearl River, NY). An open control group received three doses of diphtheria and tetanus toxoids vaccine (DT) at 3, 4.5, and 15 to 18 months of age. Vaccine efficacy rates were calculated using a number of principal and ancillary case definitions for primary, secondary, and noncases by analyzing secondary attack rates in study infants after exposure to pertussis in the household using 7- to 28- and 7- to 42-day postexposure observation periods and the inclusion and the exclusion of noncases who received macrolide antibiotics or trimethoprim-sulfamethoxazole during the exposure period. RESULTS During a 3.5-year study period, 10271 infants (DTP or DTaP, n = 8532; DT, n = 1739) were enrolled and actively followed along with all household members for cough illnesses. Depending on the case definition, 160 to 519 household exposures to pertussis were identified. In general, secondary attack rates in DT recipients were low and this was primarily because of the frequent use of antimicrobial prophylaxis. Using the principal case definitions and the exclusion of noncases who received macrolide antibiotics or trimethoprim-sulfamethoxazole during the exposure period and the 7- to 42-day observation period, the efficacy of DTP against cough illness of greater than or equal to 7 days duration caused by Bordetella pertussis was 84% (95% confidence interval [CI] = 65-93) and that of DTaP was 58% (95% CI = 30-75). Using similar criteria, the efficacy against typical pertussis (greater than or equal to 21 days of cough with either paroxysms, whoop, or posttussive vomiting) was 94% (95% CI = 77-99) and 86% (95% CI = 62-95) for DTP and DTaP, respectively. The efficacy against any cough illness (with or without) laboratory confirmation was 54% (95% CI = 32-69) and 38% (95% CI = 13-56) for DTP and DTaP, respectively. CONCLUSION This household contact substudy within our cohort study, with active investigator-generated surveillance, was a severe test of vaccine efficacy. Both vaccines (DTP and DTaP) are better at preventing typical pertussis than mild illness. When case definitions similar to those in other recent trials are used, the Lederle/Takeda vaccine has an efficacy similar to other multicomponent DTaP vaccines.
What the Science of Morality Doesn’t Say About Morality

In this article I ask what recent moral psychology and neuroscience can and can’t claim to have discovered about morality. I argue that the object of study of much recent work is not morality but a particular kind of individual moral judgment. But this is a small and peculiar sample of morality. There are many things that are moral yet not moral judgments. There are also many things that are moral judgments yet not of that particular kind. If moral things are various and diverse, then empirical research about one kind of individual moral judgment doesn’t warrant theoretical conclusions about morality in general. If that kind of individual moral judgment is a peculiar and rare thing, then it is not obvious what it tells us about other moral things. What is more, it is not obvious what its theoretical importance is to begin with—that is, why we should care about it at all. In light of these arguments, I call for a pluralism of methods and objects of inquiry in the scientific investigation of morality, so that it transcends its problematic overemphasis on a particular kind of individual moral judgment.
Reduced Inhibition of Dentate Granule Cells in a Model of Temporal Lobe Epilepsy

Patients and models of temporal lobe epilepsy have fewer inhibitory interneurons in the dentate gyrus than controls, but it is unclear whether granule cell inhibition is reduced. We report the loss of GABAergic inhibition of granule cells in the temporal dentate gyrus of pilocarpine-induced epileptic rats. In situhybridization for GAD65 mRNA and immunocytochemistry for parvalbumin and somatostatin confirmed the loss of inhibitory interneurons. In epileptic rats, granule cells had prolonged EPSPs, and they discharged more action potentials than controls. Although the conductances of evoked IPSPs recorded in normal ACSF were not significantly reduced and paired-pulse responses showed enhanced inhibition of granule cells from epileptic rats, more direct measures of granule cell inhibition revealed significant deficiencies. In granule cells from epileptic rats, evoked monosynaptic IPSP conductances were <40% of controls, and the frequency of GABAA receptor-mediated spontaneous and miniature IPSCs (mIPSCs) was <50% of controls. Within 3–7 d after pilocarpine-induced status epilepticus, miniature IPSC frequency had decreased, and it remained low, without functional evidence of compensatory synaptogenesis by GABAergic axons in chronically epileptic rats. Both parvalbumin- and somatostatin-immunoreactive interneuron numbers and the frequency of both fast- and slow-rising GABAA receptor-mediated mIPSCs were reduced, suggesting that loss of inhibitory synaptic input to granule cells occurred at both proximal/somatic and distal/dendritic sites. Reduced granule cell inhibition in the temporal dentate gyrus preceded the onset of spontaneous recurrent seizures by days to weeks, so it may contribute, but is insufficient, to cause epilepsy.
Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

Objectives Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) appear before disease onset and are associated with bone destruction. We aimed to dissect the role of ACPAs in osteoclast (OC) activation and to identify key cellular mediators in this process. Methods Polyclonal ACPA were isolated from the synovial fluid (SF) and peripheral blood of patients with RA. Monoclonal ACPAs were isolated from single SF B-cells of patients with RA. OCs were developed from blood cell precursors with or without ACPAs. We analysed expression of citrullinated targets and peptidylarginine deiminases (PAD) enzymes by immunohistochemistry and cell supernatants by cytometric bead array. The effect of an anti-interleukin (IL)-8 neutralising antibody and a pan-PAD inhibitor was tested in the OC cultures. Monoclonal ACPAs were injected into mice and bone structure was analysed by micro-CT before and after CXCR1/2 blocking with reparixin. Results Protein citrullination by PADs is essential for OC differentiation. Polyclonal ACPAs enhance OC differentiation through a PAD-dependent IL-8-mediated autocrine loop that is completely abolished by IL-8 neutralisation. Some, but not all, human monoclonal ACPAs derived from single SF B-cells of patients with RA and exhibiting distinct epitope specificities promote OC differentiation in cell cultures. Transfer of the monoclonal ACPAs into mice induced bone loss that was completely reversed by the IL-8 antagonist reparixin. Conclusions We provide novel insights into the key role of citrullination and PAD enzymes during OC differentiation and ACPA-induced OC activation. Our findings suggest that IL8-dependent OC activation may constitute an early event in the initiation of the joint specific inflammation in ACPA-positive RA.
The Implementation and Maintenance of a Behavioral Safety Process in a Petroleum Refinery

A values-centered and team-based behavioral safety process was implemented in a petroleum oil refinery. Employee teams defined the refinery's safety values and related practices, which were used to guide the process design and implementation. The process included (a) a safety assessment; (b) the clarification of safety-related values and related practices; (c) process design and executive overview; (d) safety-observation training; (e) feedback, recognition, and celebration; and (f) process maintenance. Data that span 20 years are presented to show the long-term impact on recordable incidents, lost-time cases, and direct costs of injuries. The implementation was associated with an 81% decrease in recordable incidents, a 79% decrease in lost-time cases, and a 97% savings in annual workers' compensation costs over an eight-year period. An interview with the vice president of the refinery is presented to highlight the process's influence on the refinery's safety culture.
The history and culture of the newsroom in Germany

Today journalistic production takes place within “editorial offices” or “newsrooms”. But such newsrooms did not exist when newspapers first emerged. This paper describes, based primarily on the evidence of building structure and architectural floor plans, when and why special newsrooms were created in Germany and how they developed. At first these rooms were small, and journalists often resided there too. From the late nineteenth century editorial offices became differentiated and, in the German case typically became separate rooms reflecting newspapers' different editorial subjects and sections, thereby fostering their journalistic autonomy. Only recently can changes towards alternative structures and open-plan offices be observed. Meanwhile the production of internet news returns to an organization that does not require a newsroom. This paper argues that newsroom structure has influenced journalism in Germany, which did not change its production routines much after World War II when the American journalism style was declared to be the standard.
Verbal and Nonverbal Behavior in Single-Sex and Mixed-Sex Groups: Are Traditional Sex Roles Changing?

The study examines the degree to which traditional sex differences in behavioral interaction in groups obtain even in a sample of very bright, career-oriented men and women who are similar in respect to a variety of personality attributes and personal aspirations. 21 experimental groups were studied, 7 all-male, 6 all-female, and 8 mixed-sex groups. Groups were composed of 5 or 6 members. Each group had 40 min. to discuss an ethical dilemma and come to a consensus decision. The data indicated that, while rates of interaction departed from traditional sex-role stereotypes, with females dominating the mixed groups verbally, interaction styles and nonverbal postures remained sex-role stereotypic. Males devoted a greater proportion of their interaction to task behavior, i.e., giving opinions, suggestions, and information, and the females to reactions, i.e., agreements and disagreements. Males exceeded females in displays of nonverbal postures associated with dominance. Most behavioral measures were not affected by the sex composition of the group. Implications of these findings for work settings are discussed.
Image Quality Assessment for Fake Biometric Detection: Application to Iris, Fingerprint, and Face Recognition

To ensure the actual presence of a real legitimate trait in contrast to a fake self-manufactured synthetic or reconstructed sample is a significant problem in biometric authentication, which requires the development of new and efficient protection measures. In this paper, we present a novel software-based fake detection method that can be used in multiple biometric systems to detect different types of fraudulent access attempts. The objective of the proposed system is to enhance the security of biometric recognition frameworks, by adding liveness assessment in a fast, user-friendly, and non-intrusive manner, through the use of image quality assessment. The proposed approach presents a very low degree of complexity, which makes it suitable for real-time applications, using 25 general image quality features extracted from one image (i.e., the same acquired for authentication purposes) to distinguish between legitimate and impostor samples. The experimental results, obtained on publicly available data sets of fingerprint, iris, and 2D face, show that the proposed method is highly competitive compared with other state-of-the-art approaches and that the analysis of the general image quality of real biometric samples reveals highly valuable information that may be very efficiently used to discriminate them from fake traits.
Children in permanent foster care in Sweden

The Swedish child welfare system has no permanency planning as we know it from, for example, the United States and Great Britain. Regardless of whether the child is placed in foster care with or without the parents’ consent, the law requires semi-annual reviews and there is no time limit set on reunion. Nevertheless, there are foster children who remain in the foster home throughout the whole of childhood, on terms similar to permanent foster care or adoption. This paper concerns a selection of findings from a research project entitled ‘Is there a difference in being a foster child? ’. Foster children aged 10–11 were interviewed three times and the children’s perspective was focused on, complemented by the perspective of their foster parent(s). When interviewed about their relationship to their natural family as well as to the foster family, and about having a sense of family belonging and expectations for the future, 11 of the 22 children perceived their stay in the foster home as permanent and regarded themselves as belonging only to the foster family, although all of the children had contact with their birth parents. The study concerns the children’s views as well as those of the foster parents. The perception of permanency in the absence of a legal option of permanency is discussed.
Women Matter in Newsrooms: How Power and Critical Mass Relate to the Coverage of the HPV Vaccine

This study explored how female journalists affect news content when holding positions of power, reaching a critical mass in the newsroom, and covering an issue that appeals to them. The study compared a male-dominated news organization's coverage of the human papilloma virus (HPV) vaccine with coverage by a more gender-balanced organization in terms of news executives and reporters. It also explored whether content produced by female reporters from both organizations differed. The more gender-balanced organization covered the vaccine more frequently and more prominently, and used more diverse themes than its counterpart. The content created by female reporters at different outlets also diverged.
Endophthalmitis after filtering surgery with mitomycin.

OBJECTIVE To identify the incidence, causative organisms, and clinical outcomes of eyes with bleb-associated endophthalmitis after glaucoma filtering procedures with adjunctive mitomycin. METHODS Retrospective analysis of 773 consecutive eyes that underwent glaucoma filtering surgery at the Bascom Palmer Eye Institute, Miami, Fla. The course of 609 eyes from 485 patients with a minimum of 3 months of follow-up were reviewed. RESULTS Mean follow-up was 16.0 +/- 11.5 months (range, 3-48 months). Of the 609 eyes, 13 (2.1%) developed bleb-associated endophthalmitis an average of 18.5 +/- 13.2 months after surgery (range, 1-45 months). The incidence of bleb-associated endophthalmitis was significantly greater after inferior trabeculectomy (7.8% per patient-year) than after superior trabeculectomy (1.3% per patient-year) by Kaplan-Meier estimates (P = .02, log rank test). The cumulative incidence was 13% for inferior limbal blebs and 1.6% for superior limbal blebs. Nine (69.2%) of the 13 eyes were culture positive. Streptococcus sanguis and Haemophilus influenzae (6/13 [46.2%]) were the most frequent causative organisms. The mean increase in intraocular pressure after endophthalmitis treatment was 1.2 mm Hg, with a mean decrease in visual acuity of 1.42 logMAR units. Eight (61.5%) of the 13 eyes had a final acuity of 20/400 or better. CONCLUSIONS The incidence of bleb-associated endophthalmitis after guarded filtering surgery performed with adjunctive mitomycin is higher than the reported rate in eyes undergoing filtering surgery without the use of antifibrotic agents (0.2%-1.5%). Inferior limbal trabeculectomy carries the highest risk of infection. Eyes with mitomycin blebs maintained excellent filtration capacity. However, after treatment of the infection, the visual outcomes were generally poor.
Democracy and Elections in Africa

Democracy and Elections in Africa. By Steffan Lindberg. Baltimore: Johns Hopkins University Press, 2006. 240p. $55.00 cloth, $24.95 paper. This book is an original, important, and in many ways impressive study that will make a contribution to both electoral and Africanist scholarship. The author's central argument is that repetitive elections (three or more) increase the democratic qualities of regimes and broaden and deepen civil liberties in societies. This argument is carefully placed within democratic theory and rigorously tested by a dense and generally sophisticated empirical analysis, although I have criticisms regarding the tightness of the theory and two variables used in the empirical analysis.
What teachers don't know and why they aren't learning it: addressing the need for content and pedagogy in teacher education

This article discusses the lingering problem of poor and inappropriate preparation of professional teachers of reading and learning disabilities – why it exists and what we can do about it. Because most students classified as having learning disabilities experience primary difficulties with language-based learning, teachers must know how to teach the forms and processes of language on which literacy depends, but most teacher preparation programs fail to teach this content at a level that supports teachers' implementation of effective instruction. The evidence suggests that teachers may cling to unproductive philosophies of teaching not only because science-based instruction is neglected in many teacher training programs, but also because the requisite insights are elusive and the content is difficult for many to grasp, even with some exposure. While ideologies can be blamed for much resistance to explicit, systematic methodologies, we must ask why they develop in the first place. Although there is a substantial body of research on the relationship between teacher knowledge, practice, and student outcomes in reading on which to build reform in teacher training and mentoring, more thought should be given to how prospective teachers are taught. First, the disciplinary knowledge base required to teach students with reading and related difficulties must be unambiguously explained in the standards by which teachers are educated and evaluated, and then programs must be set up to build teachers' insight as well as their knowledge of basic reading psychology, language structure, and pedagogy. Those who teach teachers in university settings or who provide professional development must be included in a supportive educational process, as wars of ideology are having only limited positive effects.
Creative holism: a critical systems approach to complex problem situations

The 49th Annual Meeting of the International Society for the Systems Sciences had, as its theme, ‘the potential impacts of systemics on society’. As my contribution to this, I want to discuss why I think a critical systems approach called ‘creative holism’ can help managers address complex problem situations. As is frequently stated, managers today face increasing complexity, change and diversity. Furthermore, the solutions they are offered to help them cope in this situation rarely seem to work. In this paper, it is argued that those solutions fail because they are not holistic or creative enough. The benefits to be gained from holism and creativity (in a systemic sense) are outlined, and a practical approach, ‘creative holism’, is specified which aims to better equip managers to deal with complex problem situations. If the argument is right then systemics has the potential to have both a significant and a beneficial impact upon society in the years to come. Copyright © 2006 John Wiley & Sons, Ltd.
Informal Factors in Career Achievement

Study of 226 careers in a managerial hierarchy revealed no formal pattern of selection and promotion in terms of age at entry, rate of advancement, occupational experience, or type of educational training. But informal processes of selection appeared to function significantly through the use of such criteria as religion, ethnic composition, political belief, and participation in accepted organizations.
The Political Aspect of Reform: Teacher Resistance as Good Sense

This article provides a careful reading of what we refer to as the school change literature. Focusing on some of the prominent scholars within this tradition -- Havelock, Huberman, Miles, Sarason, Fullan, Hargreaves, and Rosenholtz -- we use empirical evidence from a case study of site-based decision making to argue that the emphasis within this tradition on promoting teacher engagement in reform endeavors obscures the political insights of those teachers who resist reform. Whether school change researchers recommend expert assistance or the development of collaborative school cultures as a way to achieve successful reform, the potential good sense embodied in teachers' resistance to innovation efforts tends to be discounted. Considering the possibility that the acts of resistant teachers reflect good sense, our study indicates that the school change literature overlooks the preconditions for reform: the fundamental restructuring of teachers' work. Given the long history of teacher resistance to reform, and their continuing concern about issues of time and authority, we suggest that current reform proposals focus on these issues not only to alter the class and gender bias embedded in the construction of teachers' work, but also to avoid the push-pull cycle where outsiders push for reforms and teachers resist, leaving schools fundamentally unchanged.
The benefits of empathy: When empathy may sustain cooperation in social dilemmas

Cooperation in social dilemmas is often challenged by negative noise, or unintended errors, such that the actual behavior is less cooperative than intended—for example, arriving later than intended for a meeting due to an unusual traffic jam. The present research was inspired by the notion that doing a little more for one's interaction partner, which may be movitvated by empathetic feelings, can effectively reduce the detrimental effects of “negative noise,” or unintended incidents of noncooperation. Consistent with hypotheses, negative noise exhibited detrimental effects on cooperation, but such effects were absent when empathy-motivated cooperation was present. We conclude that empathy has broad benefits for social interaction, in that it can be an effective tool for coping with misinterpreted behaviors, thereby maintaining or enhancing cooperation. Copyright © 2009 John Wiley & Sons, Ltd.
Student Involmement in University Governance: A Need for Negotiated Educational Aims?

The paper argues for the need toincrease student participation in universitygovernance, especially in relation tohigh-level decision-making concerning the aimsand mission of tertiary institutions. The paperexamines the arguments in favour of, andagainst, student participation in universitygovernance. It also provides an overview ofthe findings of recent empirical studies on thetopic. The need for a process of negotiation inthe setting of higher education aims isemphasised and several suggestions are offeredregarding ways of increasing studentinvolvement in the aims-setting process.