Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between deep bite and the periodontal status of anterior teeth

To analyze the relationship between deep bite and periodontal status. A cross-sectional study of 52 normal bite subjects and 52 deep bite subjects using patients’ dental records from Teaching hospital Faculty of Dentistry Universitas Indonesia. Statistical analysis was conducted with the Mann-Whitney U test. There were statistically significant differences (p>0.05) in the mean values of pocket depth, gingival recession, loss of attachment, and gingival bleeding between normal bite and deep bite groups. There were associations between deep bite and the increase in pocket depth, gingival recession, loss of attachment, and gingival bleeding. Whilst in deep bite patients, the maxillary palatogingival and the mandibular lingual gingival tissues showed the highest levels of damage. Clinical article (J Int Dent Med Res 2018; 11(3): 1028-1031)
Analysis of Gene Expression Using Gene Sets Discriminates Cancer Patients with and without Late Radiation Toxicity

Background Radiation is an effective anti-cancer therapy but leads to severe late radiation toxicity in 5%–10% of patients. Assuming that genetic susceptibility impacts this risk, we hypothesized that the cellular response of normal tissue to X-rays could discriminate patients with and without late radiation toxicity. Methods and Findings Prostate carcinoma patients without evidence of cancer 2 y after curative radiotherapy were recruited in the study. Blood samples of 21 patients with severe late complications from radiation and 17 patients without symptoms were collected. Stimulated peripheral lymphocytes were mock-irradiated or irradiated with 2-Gy X-rays. The 24-h radiation response was analyzed by gene expression profiling and used for classification. Classification was performed either on the expression of separate genes or, to augment the classification power, on gene sets consisting of genes grouped together based on function or cellular colocalization. X-ray irradiation altered the expression of radio-responsive genes in both groups. This response was variable across individuals, and the expression of the most significant radio-responsive genes was unlinked to radiation toxicity. The classifier based on the radiation response of separate genes correctly classified 63% of the patients. The classifier based on affected gene sets improved correct classification to 86%, although on the individual level only 21/38 (55%) patients were classified with high certainty. The majority of the discriminative genes and gene sets belonged to the ubiquitin, apoptosis, and stress signaling networks. The apoptotic response appeared more pronounced in patients that did not develop toxicity. In an independent set of 12 patients, the toxicity status of eight was predicted correctly by the gene set classifier. Conclusions Gene expression profiling succeeded to some extent in discriminating groups of patients with and without severe late radiotherapy toxicity. Moreover, the discriminative power was enhanced by assessment of functionally or structurally related gene sets. While prediction of individual response requires improvement, this study is a step forward in predicting susceptibility to late radiation toxicity.
Real Options in Management and Organizational Strategy: A Review of Decision‐Making and Performance Implications

This paper contributes to the debate on the role of real options theory in business strategy and organizational decision-making. It analyses and critiques the decision-making and performance implications of real options within the management theories of the (multinational) firm, reviews and categorizes the organizational, strategic and operational facets of real options management in large business settings. It also presents the views of scholars and practitioners regarding the incorporation and validity of real options in strategy, international management and business processes. The focus is particularly on the decision-making and performance attributes of the real options logic concerning strategic investments, governance modes and multinational operations management. These attributes are examined from both strategic and operating perspectives of decision-making in organizations, also with an overview of the empirical evidence on real options decision-making and performance.
Relapsed High-Risk Medulloblastoma: Stable Disease after Two Years of Treatment with Somatostatin Analog - Case Report

Cerebellar medulloblastoma in adults is an uncommon disease. Therefore, most information comes from the pediatric population, and the treatment for relapses is based on series and case reports. The expression of somatostatin receptors has been identified in most medulloblastoma patients, and preclinical experience has shown a promissory response to somatostatin analogs. This report presents a female patient with a high-risk left cerebellar medulloblastoma diagnosed at age 16 years old who was treated with complete resection, cranial-spinal radiotherapy, and chemotherapy. She presented again at 18 years of age with a sustained progression of her tumor, despite radiosurgery and another line of chemotherapy. Octreotide scintigraphy at that time showed a moderate to high expression of somatostatin receptors; thus, the patient was started on monthly octreotide. She is now 20 and has achieved stable disease over more than two years of active treatment without any drug-related toxicity. Somatostatin analogs could be considered as a treatment option in selected cases of medulloblastoma. Review of the literature is presented for this unusual response.
TH 4 B-2 Accurate Characteristic Impedance Measureanent on Silicon

This paper presents a new method that accurately determines the characteristic impedance of planar transmission lines printed on lossy dielectrics even when contact-pad capacitance and conductance are large. We demonstrate the method on a coplanar waveguide fabricated on fused silica and a microstrip line fabricated on a highly conductive silicon substrate.
The Effect of the Mandatory Application of IFRS on the Value Relevance of Accounting Data: Some Evidence from Greece

In this study we tested the effect of the mandatory adoption of IFRS upon the value relevance of earnings and book values using data from the Athens Stock Exchange that covered a period of two years before and two years after the mandatory adoption of IFRS. Greece is a code-law country with strong tax conformity, bank orientation and conservative accounting rules which have a negative effect on the value relevance of financial statements. As IFRS adoption promotes fair value accounting and weakens the link between taxation and accounting rules we expect earnings and book value to become more value relevant ceteris paribus. We report that the adoption of IFRS positively affected the value relevance of consolidated net income and book value although it had no effect on their unconsolidated counterparts and that consolidated accounting numbers are by far more value relevant than unconsolidated ones in both periods and, unexpectedly, this superiority is more pronounced after IFRS adoption. We also report that disaggregating net income increases the explanatory power of the earnings – book value capitalization (EBVC) model. Finally, we report that although the overall explanatory power of the model increases, the incremental explanatory power of both net income and financial income decreases. These last findings question the expected benefits of specific IFRS rules concerning the measurement of these income components. Nevertheless, assuming that the total impact of IFRS adoption is captured by the overall explanatory power of the models which actually increased, we conclude that mandating IFRS may prove beneficial even in an unfavorable context.
Feasibility of Computed Diffusion Weighted Imaging and Optimization of b-value in Cervical Cancer

Purpose: To evaluate the feasibility of computed diffusion weighted imaging (DWI) in cervical cancer and investigate the optimal b-value using computed DWI. Methods: The present retrospective study involved 85 patients with cervical cancer in the International Federation of Gynecology and Obstetrics (FIGO) stage IB, IIA or IIB. DWI was obtained with b-values of 0, 100, 500 and 1000 s/mm2. Computed DWI with b-values of 800, 1000, 1300, 1600 and 2000 s/mm2 (cDWI800, cDWI1000, cDWI1300, cDWI1600, cDWI2000) were generated from all measured DWI (mDWI) data. Qualitatively, computed DWI was evaluated in terms of tumor conspicuity, signal suppression of the fat in the imaged area and total image quality by two radiologists independently with reference to mDWI with b-value of 1000 s/mm2. The b-value at which the signal of the endocervical canal was suppressed was recorded. Quantitatively, the signal intensities of tumor, myometrium, endocervical canal, endometrium, and gluteal subcutaneous fat were measured and represented as contrast ratios (CR). Results: Regarding tumor conspicuity and total image quality, significantly higher scores were obtained at cDWI1300 and cDWI1600 compared to the others (post-hoc comparison, P < 0.001), except for the total image quality between cDWI1000 and cDWI1600 in one reader. Signal suppression of the fat was the worst at cDWI2000. The signal intensity of the endocervical canal was suppressed in 24/27 cases on cDWI1600 and in 26/27 cases on cDWI2000. The CRs of tumor to myometrium, cervix, and endometrium increased with higher b-values, while the CRs of tumor to fat decreased and were statistically significant (post-hoc comparison, P < 0.001). Conclusion: Computed DWI with the b-values of 1300 and 1600 would be suitable for the evaluation of cervical cancer due to good tumor conspicuity.
Quantification of Cardiac Ventricular Repolarization and its Spatial Dispersion through the Surface Electrocardiogram

2 Assistant Researcher, National Scientific and Technological Research Council (CONICET) Associate Professor,National University of San Juan (UNSJ) Department of Medical Technology, School of Engineering, National University of San Juan Address for reprints: Dr. Ing. Pedro David Arini Instituto Argentino de Matemática, CONICET Saavedra 15 3o Piso (1083) Ciudad Autónoma de Buenos Aires, Argentina Phone number: (011) 4954-6781 extension 118 Fax: (011) 4954-6782 e-mail: pedroarini@yahoo.com. ar pedro.arini@conicet.gov. ar SUMMARY
Maximum intrinsic rate of population increase in sharks, rays, and chimaeras: the importance of survival to maturity

The maximum intrinsic rate of population increase rmax is a commonly estimated demographic parameter used in assessments of extinction risk. In teleosts, rmax can be calculated using an estimate of spawners per spawner, but for chondrichthyans, most studies have used annual reproductive output b instead. This is problematic as it effectively assumes all juveniles survive to maturity. Here, we propose an updated rmax equation that uses a simple mortality estimator which also accounts for survival to maturity: the reciprocal of average lifespan. For 94 chondrichthyans, we now estimate that rmax values are on average 10% lower than previously published. Our updated rmax estimates are lower than previously published for species that mature later relative to maximum age and those with high annual fecundity. The most extreme discrepancies in rmax values occur in species with low age at maturity and low annual reproductive output. Our results indicate that chondrichthyans that mature relatively later in life, and to a lesser extent those that are highly fecund, are less resilient to fishing than previously thought.
Establishing Smoke-Free Homes in the Indigenous Populations of Australia, New Zealand, Canada and the United States: A Systematic Literature Review

A smoke-free home can have multiple benefits by reducing exposure to secondhand smoke (SHS), supporting quit attempts among active smokers, and discouraging adolescents from taking up smoking. The aim of this review was to summarize the literature on the establishment of smoke-free homes in Indigenous populations and identify the supporting influences and barriers, using the Social Cognitive Theory lens. A search of the Medline, CINAHL, Cochrane Collaboration and PyscINFO databases and manual searches of relevant peer-reviewed literature was completed, focusing on Indigenous populations in developed economies of North America and Oceania. Of 2567 articles identified, 15 studies were included. Ten studies included Indigenous participants only, and of these just three focused entirely on SHS in the home. Knowledge of the harms associated with SHS was the most common theme represented in all the studies. This knowledge fueled parents’ motivation to protect their children from SHS by establishing smoke-free homes. Individuals who approached implementation with confidence, coupled with clear communication about smoke-free home rules were more successful. Barriers included challenges for families with multiple smokers living in the same dwelling. There is limited research regarding managing smoking behaviors in the home among Indigenous populations, even though this approach is a successful catalyst for smoking prevention and cessation. Research to understand the influences that support the establishment of smoke-free homes is required for better-informed intervention studies.
Evolutionary Approach to Test Generation for Functional BIST

In the paper, an evolutionary approach to test generation for functional BIST is considered. The aim of the proposed scheme is to minimize the test data volume by allowing the device's microprogram to test its logic, providing an observation structure to the system, and generating appropriate test data for the given architecture. Two methods of deriving a deterministic test set at functional level are suggested. The first method is based on the classical genetic algorithm with binary and arithmetic crossover and mutation operators. The second one uses genetic programming, where test is represented as a sequence of microoperations. In the latter case, we apply two-point crossover based on exchanging test subsequences and mutation implemented as random replacement of microoperations or operands. Experimental data of the program realization showing the efficiency of the proposed methods are presented.
Lysosomal membrane dynamics: structure and interorganellar movement of a major lysosomal membrane glycoprotein

The biochemistry and intracellular transit of an integral membrane glycoprotein of chicken fibroblast lysosomes were studied with monoclonal antibody techniques. The glycoprotein had an apparent molecular weight of 95,000-105,000. Structural analysis involving metabolic labeling with [35S]methionine and cleavage with glycosidases revealed the presence of numerous oligosaccharide chains N-linked to a core polypeptide of apparent molecular weight 48,000. A primary localization of the glycoprotein to lysosomes was demonstrated by the coincidence of antibody binding sites with regions of acridine orange uptake, electron immunocytochemical labeling on the inner surface of lysosome-like vacuolar membranes, and preferential association of the glycoprotein with lysosome-enriched subcellular fractions from Percoll gradients. In addition, small quantities of the glycoprotein were detected on endocytic vesicle and plasma membranes. To study the intracellular pathway of the glycoprotein, we used a monoclonal antibody whose binding to the glycoprotein at the cell surface had no effect on the number or subcellular distribution of antigen molecules. Incubation of chicken fibroblasts with monoclonal antibody at 37 degrees C led to the rapid uptake and subsequent delivery of antibody to lysosomes, where antibody was degraded. This process continued undiminished for many hours on cells continuously exposed to the antibody and was not blocked by the addition of cycloheximide. The rate at which antigen sites were replenished in the plasma membrane of cells prelabeled with antibody (t1/2 = 2 min) was essentially equivalent to the rate of internalization of antibody bound to cell surfaces. These results suggest that there is a continuous and rapid exchange of this glycoprotein between plasma membrane and the membranes of endosomes and/or lysosomes.
The Multifaceted Functions of CXCL10 in Cardiovascular Disease

C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family. Its members are responsible for leukocyte trafficking and act on tissue cells, like endothelial and vascular smooth muscle cells. CXCL10 is secreted by leukocytes and tissue cells and functions as a chemoattractant, mainly for lymphocytes. After binding to its receptor CXCR3, CXCL10 evokes a range of inflammatory responses: key features in cardiovascular disease (CVD). The role of CXCL10 in CVD has been extensively described, for example for atherosclerosis, aneurysm formation, and myocardial infarction. However, there seems to be a discrepancy between experimental and clinical settings. This discrepancy occurs from differences in biological actions between species (e.g. mice and human), which is dependent on CXCL10 signaling via different CXCR3 isoforms or CXCR3-independent signaling. This makes translation from experimental to clinical settings challenging. Furthermore, the overall consensus on the actions of CXCL10 in specific CVD models is not yet reached. The purpose of this review is to describe the functions of CXCL10 in different CVDs in both experimental and clinical settings and to highlight and discuss the possible discrepancies and translational difficulties. Furthermore, CXCL10 as a possible biomarker in CVD will be discussed.
Postharvest Application of Chitosan and Low Temperature Storage Affect Respiration Rate and Quality of Plum Fruits

Application of edible coating as a way of prolonging the shelf-life of perishable fruits and vegetables is promising. Two plum cultivars (Stanley and Giant) were treated with 1% Chitosan and then stored at 0-1C and relative humidity of 90±5% for 40 days. Changes in weight loss, respiration rate, fruit firmness, soluble solid content, titrable acidity, pH, ascorbic acid as well as decay rate were periodically recorded. The results indicated that Chitosan coating was effective in reducing weight loss, respiration rate as well as decay rate. A parallel trend in weight loss and decay rate was observed for both cultivars. Comparing the two cultivars, ‘Giant’ exhibited higher weight loss and respiration rate. Weight loss was mitigated through Chitosan application due to its positive effect in reducing respiration. In addition, Chitosan coating resulted in the retainment of a higher content of titrable acid, pH as well as firmness in either cultivar. However, total soluble solids and ascorbic acid contents were not significantly affected by the coating. The results finally indicated that Chitosan treatment is an effective strategy for maintaining organoleptic characteristics and as well for the prolonging of postharvest
Macroeconomic Conditions, Growth Opportunities and the Cross-Section of Credit Risk

This paper develops a dynamic trade-off model of optimal capital structure that takes into ac- count the fact that most firms have both invested assets and growth opportunities. These two sources of value react quite differently to business cycle risk. In particular, growth options are more sensitive to regime changes than invested assets. "Growth firms" are, therefore, endoge- nously more likely to default in recession, when doing so is expensive. This in turn raises their costs of debt. The model quantitatively matches average stylized facts regarding credit spreads, leverage, default and investment clustering. Importantly, it also makes predictions about the cross-section of all these features.
THE AWAKE ELECTRON SPECTROMETER

The AWAKE experiment at CERN aims to use a proton driven plasma wakefield to accelerate electrons from 10–20 MeV up to GeV energies in a 10 m plasma cell. We present the design of the magnetic spectrometer which will measure the electron energy distribution. Results from the calibration of the spectrometer’s scintillator and optical system are presented, along with a study of the backgrounds generated by the 400 GeV SPS proton beam.
Social support as a mediator between social identity and college student’s stress

This study aims to find social support as a mediator of social identity against student stress. This study uses a stage cluster random sampling technique, the subject of this study amounted to 375 students scattered on 7 faculties at Yogyakarta State University. The result of the research shows that the social identity level of students is high, social support is high and stress level is classified. The path analysis a proved significant with the value of 0.036 <0.05, on path analysis proved significant with a value of 0.016 <0.05, in path analysis proved significant with a value of 0.000 <0.05, and path analysis was proved significant with value 0.000 <0.05. Mediation analysis is evident and includes partial mediation.
Contributionofmacrophage secretoryproducts tourovirulenceof

Contributionofmacrophage secretoryproducts tourovirulenceof Pseudomonasaeruginosa Rahul Mittal, Sudhir Aggarwal, Saroj Sharma, Sanjay Chhibber & Kusum Harjai Division of Infectious Diseases, Children’s Hospital Los Angeles, Los Angeles, CA, USA; Department of Microbiology, Panjab University, Chandigarh, India; and Department of Physiology, University of Tennessee Health Sciences Center, Memphis, TN, USA
on ‘ Diet and cancer ’ Obesity and cancer

The prevalence of obesity, defined as a BMI of ‡ 30.0 kg/m, has increased substantially over previous decades to about 20% in industrialized countries, and a further increase is expected in the future. Epidemiological studies have shown that obesity is a risk factor for: postmenopausal breast cancer; cancers of the endometrium, colon and kidney; malignant adenomas of the oesophagus. Obese subjects have an approximately 1.5–3.5-fold increased risk of developing these cancers compared with normal-weight subjects, and it has been estimated that between 15 and 45% of these cancers can be attributed to overweight (BMI 25.0–29.9 kg/m) and obesity in Europe. More recent studies suggest that obesity may also increase the risk of other types of cancer, including pancreatic, hepatic and gallbladder cancer. The underlying mechanisms for the increased cancer risk as a result of obesity are unclear and may vary by cancer site and also depend on the distribution of body fat. Thus, abdominal obesity as defined by waist circumference or waist :hip ratio has been shown to be more strongly related to certain cancer types than obesity as defined by BMI. Possible mechanisms that relate obesity to cancer risk include insulin resistance and resultant chronic hyperinsulinaemia, increased production of insulin-like growth factors or increased bioavailability of steroid hormones. Recent research also suggests that adipose tissue-derived hormones and cytokines (adipokines), such as leptin, adiponectin and inflammatory markers, may reflect mechanisms linked to tumourigenesis.