Miracle-dz/UniFAR-FTUs huggingface dataset:
Journal of Basic and Clinical Pharmacy Antihepatotoxic Effect of Marrubium Vulgare and Withania Somnifera Extracts on Carbon Tetrachloride-induced Hepatotoxicity in Rats

Marrubium vulgare and Withania somnifera are used in folk medicine of several countries. Many researches showed that they are used for the treatment of variety of diseases due to their antioxidant effects. The present aim of this study was to evaluate the antihepatotoxic and antioxidant activities of the both extracts against carbon tetrachloride (CCl 4)-induced hepatic damage in rats. Both extracts were given orally in a dose of 500 mg/kg/day for 4 weeks along with CCl 4 started at the 7th week of induction of hepatotoxicity. The antihepatotoxic activity was assessed by measuring aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), glutathione peroxidase (GPx), glutathione reduct-ase (GR), glutathione-S-transferase (GST), reduced glutathione (GSH), tissue content and malondialdehyde (MDA) as well as histopathological examination. Both extracts showed a significant antihepatotoxic effect by reducing significantly the levels of AST, ALT and LDH. However, ALP levels were decreased non-significantly. Regarding the antioxidant activity, they exhibited significant effects by increasing the GPx, GR and GST activities with increased GSH tissue contents and decreased production of MDA level. Furthermore, both extracts alleviated histopathological changes in rats' liver treated with CCl 4. M. vulgare and W. somnifera protect the rats' liver against CCl 4-induced hepatotoxicity. This effect may be attributed, at least in part, to the antioxidant activities of these extracts.
Economic analysis of intercropping okra with legumes

A field study was carried out in a vegetable research field of the National Horticultural Research Institute, Ibadan, Nigeria during the late raining season of 2015 to determine the appropriate okra/legume-based cropping system that will increase crop yield and farmer’s income. The experiment was arranged in a randomized complete block design (RCBD) with three (3) replicates. The treatments comprised intercropping okra with groundnut or cowpea planted at varying spacings (60 cm x 30 cm, 60 cm x 40 cm, 60 cm x 50 cm and 60 cm x 60cm). Okra was planted at a spacing of 60 cm x 40 cm, the plot size was 3 m x 2.4 m (7.4 m). Data collected was subjected to analysis of variance (ANOVA) and significant means were separated using the least significant difference (LSD) test at the 5% probability level. Economic analysis of the cropping mixture was carried out using gross margin analysis, monetary advantage index and benefit to cost ratio analysis. Results revealed that the land equivalent ratio (LER) of 1.62 was recorded in okra/groundnut at 60 cm x 40 cm and LER of 1.74 was observed in okra/cowpea at 60 cm x 30 cm. Okra/cowpea intercropping system spaced at 60 cm x 30 cm was the most remunerative (N859,192/ha), followed by okra/cowpea spaced at 60 cm x 50 cm (N744,212/ha) while okra/cowpea spaced at 60 cm x 60 cm was the least remunerative. The highest gross margin of N2,188,961/ha was obtained in okra/groundnut spaced at 60 cm x 40 cm. The least return was obtained in okra/groundnut spaced at 60 cm x 60 cm (N700,103/ha). The economic analysis revealed that okra/cowpea spaced at 60 cm x 30 cm produced the highest gross margin of N859,192/ha and monetary advantage index of N450,447/ha while okra/groundnut spaced at 60 cm x 40 cm gave the highest gross margin of N2,188,961/ha and monetary advantage index of N924,642/ha.
WiCop: Engineering WiFi Temporal White-Spaces for Safe Operations of Wireless Body Area Networks in Medical Applications

ZigBee and other wireless technologies operating in the (2.4GHz) ISM band are being applied in Wireless Body Area Networks (WBAN) for many medical applications. However, these low duty cycle, low power, and low data rate medical WBANs suffer from WiFi co-channel interferences. WiFi interference can lead to longer latency and higher packet losses in WBANs, which can be particularly harmful to safety-critical applications with stringent temporal requirements. Existing solutions to WiFi-WBAN coexistence either require modifications to WiFi or WBAN devices, or have limited applicability. In this paper, by exploiting the Clear Channel Assessment (CCA) mechanisms in WiFi devices, we propose a novel policing framework, WiCop, that can effectively control the temporal white-spaces between WiFi transmissions. Specifically, the WiCop Fake-PHY-Header policing strategy uses a fake WiFi PHY preamble-header broadcast to mute other WiFi interferers for the duration of WBAN active interval, while the WiCop DSSS-Nulling policing strategy uses repeated WiFi PHY preamble (with its spectrum side lobe nulled by a band-pass filter) to mute other WiFi interferers throughout the duration of WBAN active interval. The resulted WiFi temporal white-spaces can be utilized for delivering low duty cycle WBAN traffic. We have implemented and validated WiCop on SORA, a software defined radio platform. Experiments show that with the assistance of the proposed WiCop policing schemes, the packet reception rate of a ZigBee-based WBAN can increase by up to 43.8% in presence of a busy WiFi interferer.
A 2D kinetic triangulation with near-quadratic topological changes

A triangulation of a set <i>S</i> of points in the plane is a subdivision of the convex hull of <i>S</i> into triangles whose vertices are points of <i>S</i>. Given a set <i>S</i> of <i>n</i> points in ℝ<sup>3</sup>, each moving independently, we wish to maintain a triangulation of S. The triangulation needs to be updated periodically as the points in <i>S</i> move, so the goal is to maintain a triangulation with small number of topological events, each being the insertion or deletion of an edge. We propose a kinetic data structure (KDS) that processes n<sup>2</sup> 2<sup>O(√log n•log log n )</sup> topological events, with high probability, if the trajectories of input points are algebraic curves of fixed degree. Each topological event can be processed in <i>O</i>(log <i>n</i>) time. This is the first known KDS for maintaining a triangulation that processes near-quadratic number of topological events, and almost matches the Ω(<i>n</i><sup>2</sup>) lower bound, [1]. The number of topological events can be reduced to nk • 2<sup>O(√log k•log log n )</sup> if only <i>K</i> of the points are moving.
Clusters of suicides and suicide attempts: detection, proximity and correlates

Background. A suicide cluster is defined as a higher number of observed cases occurring in space and/or time than would typically be expected. Previous research has largely focused on identifying clusters of suicides, while there has been comparatively limited research on clusters of suicide attempts. We sought to identify clusters of both types of behaviour, and having done that, identify the factors that distinguish suicide attempts inside a cluster from those that were outside a cluster. Methods. We used data from Western Australia from 2000 to 2011. We defined suicide attempts as admissions to hospital for deliberate self-harm and suicides as deaths due to deliberate self-harm. Using an analytic strategy that accounted for the repetition of attempted suicide within a cluster, we performed spatial-temporal analysis using Poisson discrete scan statistics to detect clusters of suicide attempts and clusters of suicides. Logistic regression was then used to compare clustered attempts with non-clustered attempts to identify risk factors for an attempt being in a cluster. Results. We detected 350 (1%) suicide attempts occurring within seven spatial-temporal clusters and 12 (0.6%) suicides occurring within two spatial-temporal clusters. Both of the suicide clusters were located within a larger but later suicide attempt cluster. In multivariate analysis, suicide attempts by individuals who lived in areas of low socioeconomic status had higher odds of being in a cluster than those living in areas of high socioeconomic status [odds ratio (OR) = 29.1, 95% confidence interval (CI) = 6.3–135.5]. A one percentage-point increase in the proportion of people who had changed address in the last year was associated with a 60% increase in the odds of the attempt being within a cluster (OR = 1.60, 95% CI = 1.29–1.98) and a one percentage-point increase in the proportion of Indigenous people in the area was associated with a 7% increase in the suicide being within a cluster (OR = 1.07, 95% CI = 1.00–1.13). Age, sex, marital status, employment status, method of harm, remoteness, percentage of people in rented accommodation and percentage of unmarried people were not associated with the odds of being in a suicide attempt cluster. Conclusions. Early identification of and responding to suicide clusters may reduce the likelihood of subsequent clusters forming. The mechanisms, however, that underlie clusters forming is poorly understood.
Host-selective toxins produced by the plant pathogenic fungus Alternaria alternata.

Host-selective toxins (HSTs) produced by fungal plant pathogens are generally low-molecular-weight secondary metabolites with a diverse range of structures that function as effectors controlling pathogenicity or virulence in certain plant-pathogen interactions. There are now seven known diseases caused by Alternaria alternata in which HSTs are responsible for fungal pathogenesis. The pathogens have been defined as pathotypes of A. alternata because of morphological similarity but pathological differences. Chemical structures of HSTs from six pathotypes have been determined. The role of A. alternata HSTs in pathogenesis has been studied extensively, and discovery of the release of HSTs from germinating conidia prior to penetration aids in understanding the early participation of HSTs to induce susceptibility of host cells by suppressing their defence reactions. Many attempts have been made to find the target sites of A. alternata HSTs, and four cellular components, plasma membrane, mitochondrion, chloroplast and a metabolically important enzyme, have been identified as the primary sites of each HST action, leading to elucidation of the molecular mechanisms of HST sensitivity in host plants. Studies of the molecular genetics of HST production have identified supernumerary chromosomes encoding HST gene clusters and have provided new insights into the evolution of A. alternata pathotypes.
THE NUMBER OF GOLDBACH REPRESENTATIONS OF AN INTEGER

Let Λ be the von Mangoldt function and R ( n )= (cid:2) h + k = n Λ( h )Λ( k ) be the counting function for the Goldbach numbers. Let N ≥ 2 and assume that the Riemann Hypothesis holds. We prove that N where ρ = 1 / 2+ iγ runs over the non-trivial zeros of the Riemann zeta-function ζ ( s ). This improves a recent result by Bhowmik and Schlage-Puchta.
Single Directional SMO Algorithm for Least Squares Support Vector Machines

Working set selection is a major step in decomposition methods for training least squares support vector machines (LS-SVMs). In this paper, a new technique for the selection of working set in sequential minimal optimization- (SMO-) type decomposition methods is proposed. By the new method, we can select a single direction to achieve the convergence of the optimality condition. A simple asymptotic convergence proof for the new algorithm is given. Experimental comparisons demonstrate that the classification accuracy of the new method is not largely different from the existing methods, but the training speed is faster than existing ones.
Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils

A new connective tissue protein, which we call fibrillin, has been isolated from the medium of human fibroblast cell cultures. Electrophoresis of the disulfide bond-reduced protein gave a single band with an estimated molecular mass of 350,000 D. This 350-kD protein appeared to possess intrachain disulfide bonds. It could be stained with periodic acid-Schiff reagent, and after metabolic labeling, it contained [3H]glucosamine. It could not be labeled with [35S]sulfate. It was resistant to digestion by bacterial collagenase. Using mAbs specific for fibrillin, we demonstrated its widespread distribution in the connective tissue matrices of skin, lung, kidney, vasculature, cartilage, tendon, muscle, cornea, and ciliary zonule. Electron microscopic immunolocalization with colloidal gold conjugates specified its location to a class of extracellular structural elements described as microfibrils. These microfibrils possessed a characteristic appearance and averaged 10 nm in diameter. Microfibrils around the amorphous cores of the elastic fiber system as well as bundles of microfibrils without elastin cores were labeled equally well with antibody. Immunolocalization suggested that fibrillin is arrayed periodically along the individual microfibril and that individual microfibrils may be aligned within bundles. The periodicity of the epitope appeared to match the interstitial collagen band periodicity. In contrast, type VI collagen, which has been proposed as a possible microfibrillar component, was immunolocalized with a specific mAb to small diameter microfilaments that interweave among the large, banded collagen fibers; it was not associated with the system of microfibrils identified by the presence of fibrillin.
Reassessing Google Flu Trends Data for Detection of Seasonal and Pandemic Influenza: A Comparative Epidemiological Study at Three Geographic Scales

The goal of influenza-like illness (ILI) surveillance is to determine the timing, location and magnitude of outbreaks by monitoring the frequency and progression of clinical case incidence. Advances in computational and information technology have allowed for automated collection of higher volumes of electronic data and more timely analyses than previously possible. Novel surveillance systems, including those based on internet search query data like Google Flu Trends (GFT), are being used as surrogates for clinically-based reporting of influenza-like-illness (ILI). We investigated the reliability of GFT during the last decade (2003 to 2013), and compared weekly public health surveillance with search query data to characterize the timing and intensity of seasonal and pandemic influenza at the national (United States), regional (Mid-Atlantic) and local (New York City) levels. We identified substantial flaws in the original and updated GFT models at all three geographic scales, including completely missing the first wave of the 2009 influenza A/H1N1 pandemic, and greatly overestimating the intensity of the A/H3N2 epidemic during the 2012/2013 season. These results were obtained for both the original (2008) and the updated (2009) GFT algorithms. The performance of both models was problematic, perhaps because of changes in internet search behavior and differences in the seasonality, geographical heterogeneity and age-distribution of the epidemics between the periods of GFT model-fitting and prospective use. We conclude that GFT data may not provide reliable surveillance for seasonal or pandemic influenza and should be interpreted with caution until the algorithm can be improved and evaluated. Current internet search query data are no substitute for timely local clinical and laboratory surveillance, or national surveillance based on local data collection. New generation surveillance systems such as GFT should incorporate the use of near-real time electronic health data and computational methods for continued model-fitting and ongoing evaluation and improvement.
The Role Of Nonhomologous End-Joining Components in Telomere Metabolism in Kluyveromyces lactis

The relationship between telomeres and nonhomologous end-joining (NHEJ) is paradoxical, as NHEJ proteins are part of the telomere cap, which serves to differentiate telomeres from DNA double-strand breaks. We explored these contradictory functions for NHEJ proteins by investigating their role in Kluyveromyces lactis telomere metabolism. The ter1-4LBsr allele of the TER1 gene resulted in the introduction of sequence altered telomeric repeats and subsequent telomere–telomere fusions (T–TFs). In this background, Lig4 and Ku80 were necessary for T–TFs to form. Nej1, essential for NHEJ at internal positions, was not. Hence, T–TF formation was mediated by an unusual NHEJ mechanism. Rad50 and mre11 strains exhibited stable short telomeres, suggesting that Rad50 and Mre11 were required for telomerase recruitment. Introduction of the ter1-4LBsr allele into these strains failed to result in telomere elongation as normally observed with the ter1-4LBsr allele. Thus, the role of Rad50 and Mre11 in the formation of T–TFs was unclear. Furthermore, rad50 and mre11 mutants had highly increased subtelomeric recombination rates, while ku80 and lig4 mutants displayed moderate increases. Ku80 mutant strains also contained extended single-stranded 3′ telomeric overhangs. We concluded that NHEJ proteins have multiple roles at telomeres, mediating fusions of mutant telomeres and ensuring end protection of normal telomeres.
Never go to sleep on undrained pus: a retrospective review of surgery for intraparenchymal cerebral abscess

Cerebral abscess is an emergency requiring urgent drainage via craniotomy or burrhole aspiration. We examine whether initial method of drainage affects outcome and important characteristics in patients with cerebral abscess. This is a retrospective analysis of 62 patients operated on in our unit with a loculated infected cerebral collection in the years 2003–2007 inclusive. Full statistical analysis was performed using data appropriate tests. Burrhole and craniotomy groups were evenly matched with no difference in any demographic factors. Surgical method made no difference to rate of re-operation (p = 0.276), antibiotic duration (p = 0.648), discharge GCS (p = 0.509), length of stay (p = 0.647) or GOS (p = 0.968). There was a trend to worsened outcome with delay to surgery (p = 0.132) with delayed patients requiring longer hospital stays (p ≤ 0.005). Patients requiring a longer antibiotic duration had worse outcomes (p ≤ 0.005). Surgical method did not have a significant effect on outcome, so burrhole aspiration with its advantages in terms of speed and scale of surgery should be strongly considered. Delay had an adverse affect, so operation should be as expeditious as possible whenever the differential diagnosis includes abscess, diagnosis of which may be aided by advanced magnetic resonance imaging techniques.
Characterization of electrochemical activity of a strain ISO2‐3 phylogenetically related to Aeromonas sp. isolated from a glucose‐fed microbial fuel cell

The microbial communities associated with electrodes in closed and open circuit microbial fuel cells (MFCs) fed with glucose were analyzed by 16S rRNA approach and compared. The comparison revealed that bacteria affiliated with the Aeromonas sp. within the Gammaproteobacteria constituted the major population in the closed circuit MFC (harvesting electricity) and considered to play important roles in current generation. We, therefore, attempted to isolate the dominant bacteria from the anode biofilm, successfully isolated a Fe (III)‐reducing bacterium phylogenetically related to Aeromonas sp. and designated as strain ISO2‐3. The isolated strain ISO2‐3 could grow and concomitantly produce current (max. 0.24 A/m2) via oxidation of glucose or hydrogen with an electrode serving as the sole electron acceptor. The strain could ferment glucose, but generate less electrical current. Cyclic voltammetry supported the strain ISO2‐3 was electrically active and likely to transfer electrons to the electrode though membrane‐associated compounds (most likely c‐type cytochrome). This mechanism requires intimate contact with the anode surface. Scanning electron microscopy revealed that the strain ISO2‐3 developed multiplayer biofilms on the anode surface and also produced anchor‐like filamentous appendages (most likely pili) that may promote long‐range electron transport across the thick biofilm. Biotechnol. Bioeng. 2009; 104: 901–910. © 2009 Wiley Periodicals, Inc.
Widespread Distribution in Pathogenic Bacteria of Di-Iron Proteins That Repair Oxidative and Nitrosative Damage to Iron-Sulfur Centers

ABSTRACT Expression of two genes of unknown function, Staphylococcus aureus scdA and Neisseria gonorrhoeae dnrN, is induced by exposure to oxidative or nitrosative stress. We show that DnrN and ScdA are di-iron proteins that protect their hosts from damage caused by exposure to nitric oxide and to hydrogen peroxide. Loss of FNR-dependent activation of aniA expression and NsrR-dependent repression of norB and dnrN expression on exposure to NO was restored in the gonococcal parent strain but not in a dnrN mutant, suggesting that DnrN is necessary for the repair of NO damage to the gonococcal transcription factors, FNR and NsrR. Restoration of aconitase activity destroyed by exposure of S. aureus to NO or H2O2 required a functional scdA gene. Electron paramagnetic resonance spectra of recombinant ScdA purified from Escherichia coli confirmed the presence of a di-iron center. The recombinant scdA plasmid, but not recombinant plasmids encoding the complete Escherichia coli sufABCDSE or iscRSUAhscBAfdx operons, complemented repair defects of an E. coli ytfE mutant. Analysis of the protein sequence database revealed the importance of the two proteins based on the widespread distribution of highly conserved homologues in both gram-positive and gram-negative bacteria that are human pathogens. We provide in vivo and in vitro evidence that Fe-S clusters damaged by exposure to NO and H2O2 can be repaired by this new protein family, for which we propose the name repair of iron centers, or RIC, proteins.
Streaming Lower Bounds for Approximating MAX-CUT

We consider the problem of estimating the value of max cut in a graph in the streaming model of computation. At one extreme, there is a trivial 2-approximation for this problem that uses only O(log n) space, namely, count the number of edges and output half of this value as the estimate for max cut value. On the other extreme, if one allows O(n) space, then a near-optimal solution to the max cut value can be obtained by storing an O(n)-size sparsifier that essentially preserves the max cut. An intriguing question is if poly-logarithmic space suffices to obtain a non-trivial approximation to the max-cut value (that is, beating the factor 2). It was recently shown that the problem of estimating the size of a maximum matching in a graph admits a non-trivial approximation in poly-logarithmic space. Our main result is that any streaming algorithm that breaks the 2-approximation barrier requires [EQUATION] space even if the edges of the input graph are presented in random order. Our result is obtained by exhibiting a distribution over graphs which are either bipartite or 1/2-far from being bipartite, and establishing that [EQUATION] space is necessary to differentiate between these two cases. Thus as a direct corollary we obtain that [EQUATION] space is also necessary to test if a graph is bipartite or 1/2-far from being bipartite. We also show that for any e > 0, any streaming algorithm that obtains a (1 + e)-approximation to the max cut value when edges arrive in adversarial order requires n1−O(e) space, implying that Ω(n) space is necessary to obtain an arbitrarily good approximation to the max cut value.