Miracle-dz/UniFAR-FTUs huggingface dataset:
Context‐awareness in the deregulated electric energy market: an agent‐based approach

Multiagent systems are commonly used for simulation of new paradigms of energy distribution. Especially when considering Smart Grids, the autonomicity deployed by goal‐driven agents implies the need for being aware of multiple aspects connected to the energy distribution context. With ‘context’, we refer to the outside world variables such as weather, stock market trends, location of the users, government actions, and so on; therefore, an architecture highly context‐aware is needed. We propose a model in which every important factor concerning the electric energy distribution is presented by modeling context‐aware agents able to identify the impact of these factors. Moreover, some tests have been performed regarding the web service integration in which agents contracting energy will automatically retrieve data to be used in adaptive and collaborative aspects; an explicative example is represented by the retrieval of weather forecasting that provides input on ongoing demand and data for the predicted availability (in case of photovoltaic or wind powered environments). Copyright © 2013 John Wiley & Sons, Ltd.
Joint Parsing and Disfluency Detection in Linear Time

We introduce a novel method to jointly parse and detect disfluencies in spoken utterances. Our model can use arbitrary features for parsing sentences and adapt itself with out-ofdomain data. We show that our method, based on transition-based parsing, performs at a high level of accuracy for both the parsing and disfluency detection tasks. Additionally, our method is the fastest for the joint task, running in linear time.
Something You do for Love: The Question of Money and Foster Care

wives or health visitors in those regions where babies are placed on a regular basis. Adoption agencies, clearly, need to take the initiative in making health authorities aware of the needs of adoptive parents. Other than the special classes held at the Norfolk and Norwich Hospital we know of only one other similar scheme. This has been run for many years by Noreen Harper, a parentcraft Sister at the Queen Mother's Hospital, Glasgow. We believe that the pioneering efforts of these two groups offer a useful model for others to follow and develop when helping first-time adopters prepare for the arrival of their baby.
Cytogenetic characterization of putative human myeloblastic leukemia cell lines (ML-1, -2, and -3): origin of the cells.

Cytogenetic studies were performed on ML cell lines (ML-1, -2, and -3), as well as on the leukemic cells of a patient from whom the ML cells were derived. The ML-1 cell line showed numerical and structural cytogenetic changes, i.e., -Y, 1p-, 6q-, 11q-, +12, +13q+, 14q-, and 17q-. The ML-2 cell line had two copies of the 13q+, whereas the ML-3 cells contained three clones, i.e., 47,X,-Y,1p-,6q-,11q-,+12,+13q+, 48,X,-Y,1p-,6q-,+6q-,11q-,+12,+13q+, and 49,X,-Y,1p-,6q-,+6q-, 11q-,+12,+13q+,+13q+. The neoplastic cells, when the patient was diagnosed as having T-cell malignant lymphoma (Stage IV), had the 11q- and 13q+. The leukemic cells in a subsequent acute myeloid leukemia phase of this patient contained structural (1p- and 6q-) and numerical (+12, -Y and +2D-group chromosomes: two 13q+) changes in addition to the 11q-. These findings suggest that the acute myeloid leukemic cells of this patient probably originated from the neoplastic cells of the preceding T-cell lymphoma, and that the chromosome changes originally seen in the lymphoma cells were preserved in the established ML cell lines, though the cells of these lines had myeloid characteristics.
Pose Space Deformation: A Unified Approach to Shape Interpolation and Skeleton-Driven Deformation

Pose space deformation generalizes and improves upon both shape interpolation and common skeleton-driven deformation techniques. This deformation approach proceeds from the observation that several types of deformation can be uniformly represented as mappings from a pose space, defined by either an underlying skeleton or a more abstract system of parameters, to displacements in the object local coordinate frames. Once this uniform representation is identified, previously disparate deformation types can be accomplished within a single unified approach. The advantages of this algorithm include improved expressive power and direct manipulation of the desired shapes yet the performance associated with traditional shape interpolation is achievable. Appropriate applications include animation of facial and body deformation for entertainment, telepresence, computer gaming, and other applications where direct sculpting of deformations is desired or where real-time synthesis of a deforming model is required.
Interpersonal psychotherapy for depression in Parkinson's disease

Studies have shown depression to affect up to 50% of individuals diagnosed with Parkinson’s disease (PD) and to have a negative impact on the progression of the illness. However, there is a dearth of research on psychosocial interventions for the treatment of depression in this population. To date, the utility of interpersonal psychotherapy (IPT), an evidence-based treatment for depression with demonstrated effectiveness in medical populations, has not been examined for this population. This case series was conducted to examine the feasibility and effectiveness of interpersonal psychotherapy (IPT) for depression in individuals with Parkinson’s disease (PD). Three PD patients with Major Depressive Disorder or Dysthymia participated in the study along with a caregiver. Patients received 6 to 15 sessions of IPT primarily focused on resolving the interpersonal problem area of role transition. Caregivers attended 1 to 2 sessions which provided psychoeducation and garnered necessary supports to help patients accomplish their treatment goals. Two of the patients experienced improvement in depressive symptoms, particularly in mood, interest and motivation in activities, with gains maintained at 1month follow-up. There was some evidence of reductions in caregiver burden as a result of the intervention, though no significant change in caregiver depressive symptoms was noted. Results of this case series suggest that IPT may be a feasible and effective option for the treatment of PD depression. Larger, controlled trials are needed to replicate these results and to further evaluate the efficacy of this intervention.
Interleukin‐8 levels and activity in delayed‐healing human thermal wounds

There are numerous causes for slow or delayed wound healing. Because slowly healing wounds are often inflamed, we quantitated the inflammatory chemokine, interleukin‐8, produced by slowly healing human burn wounds and compared this to interleukin‐8 from healed wounds and normal intact skin. Interleukin‐8 levels were increased significantly in unhealed wounds (19.7 ng/ml) compared to healed wounds (7.7 ng/ml) or normal skin (5.7 ng/ml). Interleukin‐8 in these ranges was added to adult human keratinocytes and fibroblasts. Interleukin‐8 significantly decreased keratinocyte replication but had no effect on fibroblast replication. The rate or final degree of fibroblast populated collagen lattice contraction was inhibited at interleukin‐8 concentrations between 10 and 30 ng/ml, but not altered at concentrations below 10 ng/ml and above 100 ng/ml. The concurrent application of indomethacin at 10 μg/ml reversed this interleukin‐8 induced inhibition. Interleukin‐8 inhibited myosin ATPase activity, apparently by reducing the phosphorylation of nonmuscle myosin light chain. We conclude that elevated levels of interleukin‐8 may be found during delayed healing, and these elevated interleukin‐8 levels may directly contribute to retarded wound closure.
Once more with feeling: Genes, mind and culture

Darwin, Sex and Status argues that a human sociobiology that mistakes evolutionary theory for theories of psychology and culture is wrong, as are psychologies that could never have evolved or social sciences that posit impossible psychologies. Status develops theories of human self-awareness, cognition, and cultural capacity that are compatible with evolutionary theory. Recurring themes include: the importance of sexual selection in human evolution; our species' preoccupation with self-esteem and relative standing; the individual as an active strategist, regularly revising culturally provided information; and awareness as an impressionmanagement device. Culture is a somewhat structured information pool that itself evolves, often in ways that reduce the genetic fitness of its participants.
Introductions and Questions: Rhetorical Strategies That Elicit Response in Online Communities

Conversation is a critical element to the success of online communities, both for the communities as a whole and the individual members. Yet conversations often fail: Forty percent of potential thread-starting messages in Usenet groups receive no response. When this happens, those who are trying to get information, support, or discussion from a group receive no benefit from their efforts. This paper presents a multi-method series of studies into community responsiveness to two rhetorical strategies: self-disclosing introductions and making requests. Introductions signal legitimacy and commitment, and requests reduce community effort by making clear what is needed. An analysis of a longitudinal sample of 40,931 messages from 99 Usenet groups shows that introductions referencing lurking and a personal connection to the topic of discussion increase the likelihood of getting a reply. So does making requests. Machine learning detects introductions and requests automatically within the text. A pair of experiments in which introductions and requests are added or removed from previously posted messages and reposted to Usenet groups shows that intro-ductions referencing the group history cause an increase in reply counts, but requests do not. The research will inform the design of an automatic intervention triggered at the time messages are written that makes suggestions for strengthening rhetorical strategies when the community is unlikely to respond.
A Spinal Cord Injured Animal Model of Lower Urinary Tract Function: Observations Using Direct Bladder and Pelvic Plexus Stimulation With Model Microstimulators

Abstract Background: Microstimulators are new devices that should be considered for managementof lower urinary tract problems following spinal cord injury (SCI) such as urinary retention. These devices are small(less than 25 mm by 5 mm) with the electrodes located on the ends of the stimulator. However, it is notknown whether the small electrodeson these devices would be effective in stimulating the plexus of nervesthat innervate thebladder. The aim of the present study was to provide preliminary observations with modelmicrostimulators (M-Micro) for inducing bladder contractions in an SCI animal model. Bladder wall andpelvic plexus stimulation sites were compared. Additional investigations evaluated parameters such asstimulation polarity, frequency, and period as well as bladder filling volume. Methods: In an initial survival surgery, bilateral M-Micros were implanted on the bladderwall and the pelvic plexus along the urethra in 3 female cats. A second survival surgerywas conducted 3 to 5 weeks laterto produce a Tl 0 SCI. Studies are reportedfollowing the second survival surgery. These studies included the effects of stimulation and bladder filling. Results: The postmortem location of the implanted pelvic plexus M-Micro was previouslydescribed asnear the bladder neck. Therefore, the pelvic plexus location is described in this reportas “pelvic plexus(bladder neck)”stimulation. The observations showed effective stimulation with pelvic plexus (bladder neck)stimulation andvoiding in some cases. Stimulation was limited byside effects of increased abdominalpressure and leg movement. Other factors also affected the response to stimulation, includingthe initial bladder volume and stimulating parameters. Fluoroscopy showed that when stimulation did not inducevoiding the striated urethral sphincter was closed. Conclusions: This case series of 3 SCI animals showed that the small electrodes on the M-Micro could beused to stimulate the bladder with contractions and voidingin some cases. The pelvic plexus (bladder neck)location for the M-Micro may be a better location than higher on the bladder wall. Limiting side effects ofstimulation included legmovement and increased abdominal pressure. Additional important factors included the stimulation parameters, initial bladder volume, and the function of the skeletal urethral sphincter.
Incorporating Side Information into Recurrent Neural Network Language Models

Recurrent neural network language models (RNNLM) have recently demonstrated vast potential in modelling long-term dependencies for NLP problems, ranging from speech recognition to machine translation. In this work, we propose methods for conditioning RNNLMs on external side information, e.g., metadata such as keywords, description, document title or topic headline. Our experiments show consistent improvements of RNNLMs using side information over the baselines for two different datasets and genres in two languages. Interestingly, we found that side information in a foreign language can be highly beneﬁcial in modelling texts in another language, serving as a form of cross-lingual language modelling.
Novel Expression System for Large-Scale Production and Purification of Recombinant Class IIa Bacteriocins and Its Application to Piscicolin 126

ABSTRACT Piscicolin 126 is a class IIa bacteriocin isolated from Carnobacterium piscicola JG126 that exhibits strong activity against Listeria monocytogenes. The gene encoding mature piscicolin 126 (m-pisA) was cloned into an Escherichia coli expression system and expressed as a thioredoxin-piscicolin 126 fusion protein that was purified by affinity chromatography. Purified recombinant piscicolin 126 was obtained after CNBr cleavage of the fusion protein followed by reversed-phase chromatography. Recombinant piscicolin 126 contained a single disulfide bond and had a mass identical to that of native piscicolin 126. This novel bacteriocin expression system generated approximately 26 mg of purified bacteriocin from 1 liter of E. coli culture. The purified recombinant piscicolin 126 acted by disruption of the bacterial cell membrane.
Analysis of Function After Intra-articular Fracture of the Os Calcis

Fractures of the os calcis with intra-articular involvement can cause difficulty in treatment and can result in abnormal function throughout the ankle-foot complex. We evaluated the function of the ankle-foot complex and the overall gait pattern after fracture of the os calcis, and we compared the results of surgical and nonsurgical treatment. Those in whom the geometry of the os calcis and joint was restored by reconstructive surgery had better compensation of gait and a better clinical-functional score. Complex disturbances in gait were found in the group of patients that did not undergo open reduction or internal fixation.
High-Content Screening for Compounds That Affect mtDNA-Encoded Protein Levels in Eukaryotic Cells

Compounds that interfere with the synthesis of either mitochondrial DNA or mtDNA-encoded proteins reduce the levels of 13 proteins essential for oxidative phosphorylation, leading to a decrease in mitochondrial adenosine triphosphate (ATP) production. Toxicity caused by these compounds is seldom identified in 24- to 72-h cytotoxicity assays due to the low turnover rates of both mtDNA and mtDNA-encoded proteins. To address this problem, the authors developed a 96-well format, high-content screening (HCS) assay that measures, in eukaryotic cells, the level of Complex IV–subunit 1, an mtDNA-encoded protein synthesized on mitochondrial ribosomes, and the level of Complex V–α subunit, a nuclear DNA-encoded protein synthesized on cytosolic ribosomes. The effect of several antibiotics and antiretrovirals on these 2 proteins was assessed, in transformed human liver epithelial cells, 6 days after compound treatment. The results confirmed effects of drugs known to reduce mtDNA-encoded protein levels and also revealed novel information showing that several fluoroquinolones and a macrolide, josamycin, impaired expression of mtDNA-encoded proteins. The HCS assay was robust with an average Z′ factor of 0.62. The assay enables large-scale screening of compounds to identify those that potentially affect mtDNA-encoded protein levels and can be implemented within a screening paradigm to minimize compound attrition.
Successful Comparison of US Food and Drug Administration Sentinel Analysis Tools to Traditional Approaches in Quantifying a Known Drug‐Adverse Event Association

The US Food and Drug Administration's Sentinel system has developed the capability to conduct active safety surveillance of marketed medical products in a large network of electronic healthcare databases. We assessed the extent to which the newly developed, semiautomated Sentinel Propensity Score Matching (PSM) tool could produce the same results as a customized protocol‐driven assessment, which found an adjusted hazard ratio (HR) of 3.04 (95% confidence interval [CI], 2.81–3.27) comparing angioedema in patients initiating angiotensin‐converting enzyme (ACE) inhibitors vs. beta‐blockers. Using data from 13 Data Partners between 1 January 2008, and 30 September 2013, the PSM tool identified 2,211,215 eligible ACE inhibitor and 1,673,682 eligible beta‐blocker initiators. The tool produced an HR of 3.14 (95% CI, 2.86–3.44). This comparison provides initial evidence that Sentinel analytic tools can produce findings similar to those produced by a highly customized protocol‐driven assessment.
Safety and preliminary efficacy of deep transcranial magnetic stimulation in MS-related fatigue

Objective: To conduct a randomized, sham-controlled phase I/IIa study to evaluate the safety and preliminary efficacy of deep brain H-coil repetitive transcranial magnetic stimulation (rTMS) over the prefrontal cortex (PFC) and the primary motor cortex (MC) in patients with MS with fatigue or depression (NCT01106365). Methods: Thirty-three patients with MS were recruited to undergo 18 consecutive rTMS sessions over 6 weeks, followed by follow-up (FU) assessments over 6 weeks. Patients were randomized to receive high-frequency stimulation of the left PFC, MC, or sham stimulation. Primary end point was the safety of stimulation. Preliminary efficacy was assessed based on changes in Fatigue Severity Scale (FSS) and Beck Depression Inventory scores. Randomization allowed only analysis of preliminary efficacy for fatigue. Results: No serious adverse events were observed. Five patients terminated participation during treatment due to mild side effects. Treatment resulted in a significant median FSS decrease of 1.0 point (95%CI [0.45,1.65]), which was sustained during FU. Conclusions: H-coil rTMS is safe and well tolerated in patients with MS. The observed sustained reduction in fatigue after subthreshold MC stimulation warrants further investigation. ClinicalTrials.gov identifier: NCT01106365. Classification of evidence: This study provides Class III evidence that rTMS of the prefrontal or primary MC is not associated with serious adverse effects, although this study is underpowered to state this with any precision.
Broad, Intense Anti-Human Immunodeficiency Virus (HIV) Ex Vivo CD8+ Responses in HIV Type 1-Infected Patients: Comparison with Anti-Epstein-Barr Virus Responses and Changes during Antiretroviral Therapy

ABSTRACT The ex vivo antiviral CD8+ repertoires of 34 human immunodeficiency virus (HIV)-seropositive patients with various CD4+ T-cell counts and virus loads were analyzed by gamma interferon enzyme-linked immunospot assay, using peptides derived from HIV type 1 and Epstein-Barr virus (EBV). Most patients recognized many HIV peptides, with markedly high frequencies, in association with all the HLA class I molecules tested. We found no correlation between the intensity of anti-HIV CD8+ responses and the CD4+ counts or virus load. In contrast, the polyclonality of anti-HIV CD8+ responses was positively correlated with the CD4+ counts. The anti-EBV responses were significantly less intense than the anti-HIV responses and were positively correlated with the CD4+ counts. Longitudinal follow-up of several patients revealed the remarkable stability of the anti-HIV and anti-EBV CD8+ responses in two patients with stable CD4+ counts, while both antiviral responses decreased in two patients with obvious progression toward disease. Last, highly active antiretroviral therapy induced marked decreases in the number of anti-HIV CD8+ T cells, while the anti-EBV responses increased. These findings emphasize the magnitude of the ex vivo HIV-specific CD8+ responses at all stages of HIV infection and suggest that the CD8+ hyperlymphocytosis commonly observed in HIV infection is driven mainly by virus replication, through intense, continuous activation of HIV-specific CD8+ T cells until ultimate progression toward disease. Nevertheless, highly polyclonal anti-HIV CD8+responses may be associated with a better clinical status. Our data also suggest that a decrease of anti-EBV CD8+ responses may occur with depletion of CD4+ T cells, but this could be restored by highly active antiretroviral treatment.
Hypertension as a predictive marker for bevacizumab in metastatic breast cancer: results from a retrospective matched-pair analysis.

BACKGROUND Several phase-III studies have shown improvements in terms of progression-free survival (PFS) with bevacizumab when added to chemotherapy in advanced breast cancer. However, the extent of improvement varied and none of the trials showed benefit in terms of overall survival (OS). PATIENTS AND METHODS All patients with metastatic breast cancer treated with bevacizumab at our Institution between 2005 and 2011 were retrospectively analyzed. A control group was matched according to the following variables: receptor status, treatment line, type of chemotherapy, presence of visceral disease and age. RESULTS All 212 patients were evaluable for toxicity, and 198 for response; 430 controls allowed a complete matching for 85 bevacizumab-treated patients. The addition of bevacizumab to chemotherapy significantly prolonged PFS (9.3 vs. 7.6 months, hazard ratio [HR]=0.70, 95% confidence interval [CI]=0.51-0.97, p=0.031) and OS (28.9 vs. 22.6 months, HR=0.67, 95% CI=0.45-0.99, p=0.043). Clinical benefit rate (overall response rate + stable disease for at least six months) was significantly better in the bevacizumab group (75% vs. 59%, p=0.002), while ORR did not differ significantly (48% vs. 35%, p=0.21). Patients developing hypertension during treatment had a more favourable outcome (PFS 13.7 vs. 6.6 months, HR=0.34, 95% CI=0.23-0.49 p<0.001; 2-year OS 78% vs. 30%, HR=0.20, 95% CI=0.12-0.35, p<0.001). CONCLUSION Bevacizumab in addition to chemotherapy prolonged PFS and OS in a non-selected, partly intensively pre-treated breast cancer population. Hypertension induced by bevacizumab predicted therapy efficacy.