Miracle-dz/UniFAR-FTUs huggingface dataset:
Multimodal Video-to-Near-Scene Annotation

Traditional video annotation approaches focus on annotating keyframes/shots or whole videos with semantic keywords. However, the extraction processes of keyframes/shots might lack semantic meanings, and it is hard to use a few keywords to describe the content of a long video with multiple topics. In this work, near-scenes, which contain similar concepts, topics, or semantic meanings, are designed for better video content understanding and annotation. We propose a novel framework of hierarchical video-to-near-scene annotation not only to preserve but also to purify the semantic meanings of near-scenes. To detect near-scenes, a pattern-based prefix tree is first constructed to fast retrieve near-duplicate videos. Then, the videos containing similar near-duplicate segments and similar keywords are clustered with consideration of multimodal features including visual and textual features. To enhance the precision of near-scene detection, a pattern-to-intensity-mark (PIM) method is proposed to perform precise frame-level near-duplicate segment alignment. For each near-scene, a video-to-concept distribution model is designed to analyze the representativeness of keywords and discriminations of clusters by the proposed potential term frequency and inverse document frequency and entropy. Tags are ranked according to video-to-concept distribution scores, and the tags with the highest scores are propagated to near-scenes detected. Extensive experiments demonstrate that the proposed PIM outperforms state-of-the-art approaches compared in terms of quality segments and quality frames for near-scene detection. Furthermore, the proposed framework of hierarchical video-to-near-scene annotation can achieve high quality of near-scene annotation in terms of mean average precision.
Post-basic nursing students' access to and attitudes toward the use of information technology in practice: a descriptive analysis.

BACKGROUND Nurses are exposed to the changing demands in technology as they execute their patient-related duties in the workplace. Integration of Information Technology (IT) in healthcare systems improves the quality of care provided. Nursing students with prior exposure to computers tend to have a positive influence IT. METHODOLOGY A descriptive study design using a quantitative approach and structured questionnaire was used to measure the nurses' attitudes towards computer usage. A census of 45 post-basic first year nursing management students were participated in this study. RESULTS The students demonstrated a positive attitude towards the use of a computer. But access to and use of a computer and IT was limited and nurses in clinics had no access to IT. A lack of computer skills was identified as a factor that hinders access to IT. CONCLUSION Nursing students agreed that computer literacy should be included in the curriculum to allow them to become independent computer users. The Department of Health should have IT in all health-care facilities and also train all health-care workers to use IT. IMPLICATIONS FOR NURSE MANAGERS With the positive attitudes expressed by the students, nurse managers need to create a conducive environment to ensure such a positive attitude continues to excel.
How Do People Change Their Diet?

The present study explored how people change their diet over the course of their lifespan and what factors facilitate this process. Twenty participants’ narratives were analysed using Interpretative Phenomenological Analysis. The participants’ narratives indicated that diet changes can occur either with or without the individual’s active involvement. We labelled these the active path and the passive path. Four themes emerged denoting the mechanisms of change: accumulation of evidence; trigger to action; imposed change; and seamless change. These results indicate that dietary changes may not be as infrequent and difficult as often assumed and highlight an array of new mechanisms which could be explored further to promote behaviour change.
Magnetic Resonance Imaging Determination of Normal Pituitary Gland Dimensions in Zaria, Northwest Nigerian Population

Objectives: To determine the dimensions of normal pituitary gland using T1-weighted magnetic resonance images (MRI) and to determine their relationship with age and sex. Materials and Methods: Cranial MRI scans of 100 individuals with clinically normal pituitary function (58 males and 42 females) and in the age range 14-82 years were reviewed in order to obtain volumetric measurements of the pituitary gland. The height, width, and depth of the pituitary were obtained from mid-sagittal and coronal planes, while the volume was calculated from these measured parameters. The data obtained were stratified based on age and sex for analysis. Statistical tests applied included Student′s t-test and Pearson correlation. A minimum level of statistical significance was set at P < 0.05. Results: The mean pituitary volumes were 334.1 ± 145.8 mm 3 and 328.1 ± 129.2 mm 3 while the mean pituitary heights were 6.45 ± 1.7 mm and 6.46 ± 1.57 mm in males and females, respectively. Although there was no statistically significant difference between pituitary height and pituitary volume in both sexes, they correlated negatively with increasing age (r = −202, P = 0.04 and r = −410, P = 0.000, respectively). Both parameters were highest in pubertal subjects and declined steadily with age, with a second peak occurring only for pituitary height in the sixth decade. The mean pituitary widths (9.08 ± 2.59 mm and 9.21 ± 1.86 mm) and depths (10.59 ± 1.71 mm and 10.49 ± 1.57 mm) in males and females, respectively, did not show remarkable changes with age and sex in the individuals studied. Conclusion: With this study, we have provided reference values in Nigerian population for the dimensions of normal pituitary gland, in order to facilitate assessment and diagnosis in patients with abnormalities of the hypothalamic-pituitary axis.
Isolation of an intertypic recombinant human adenovirus (candidate type 56) from the pharyngeal swab of a patient with pharyngoconjunctival fever.

1Hyogo Prefectural Institute of Public Health and Consumer Sciences, Hyogo 652-0032; 2Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 162-8640; 3Okafuji Pediatric Clinic, Himeji 671-1116; 5Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; and 4Department of Microbiology, BGC Trust Medical College, Chandanaish, Chittagong, Bangladesh
Crowding and Preselection Revisited

This paper considers the related algorithms, crowding and preselection, as potential multimodal function optimizers. It examines the ability of the two algorithms to preserve diversity, especially multimodal diversity. Crowding is analyzed in terms of the number of replacement errors it makes. Di(cid:11)erent strategies for reducing or eliminating error are proposed and examined. Finally,a variation of preselection is presented which approximates crowding, virtually eliminates replacement error, and restores selection pressure
Effects of nanoparticle zinc oxide on emotional behavior and trace elements homeostasis in rat brain

Over recent years, nanotoxicology and the potential effects on human body have grown in significance, the potential influences of nanosized materials on the central nervous system have received more attention. The aim of this study was to determine whether zinc oxide (ZnO) nanoparticles (NPs) exposure cause alterations in emotional behavior and trace elements homeostasis in rat brain. Rats were treated by intraperitoneal injection of ZnO NPs (20–30 nm) at a dose of 25 mg/kg body weight. Sub-acute ZnO NPs treatment induced no significant increase in the zinc content in the homogenate brain. Statistically significant decreases in iron and calcium concentrations were found in rat brain tissue compared to control. However, sodium and potassium contents remained unchanged. Also, there were no significant changes in the body weight and the coefficient of brain. In the present study, the anxiety-related behavior was evaluated using the plus-maze test. ZnO NPs treatment modulates slightly the exploratory behaviors of rats. However, no significant differences were observed in the anxious index between ZnO NP-treated rats and the control group (p > 0.05). Interestingly, our results demonstrated minimal effects of ZnO NPs on emotional behavior of animals, but there was a possible alteration in trace elements homeostasis in rat brain.
Stressful Life Events and the Metabolic Syndrome

OBJECTIVE Stress may play a role in the pathogenesis of the metabolic syndrome. However, the scant evidence available is not population-based, restricting the external validity of the findings. Our aim was to test associations between stressful life events, their accumulation, and the metabolic syndrome in a large population-based cohort. We also tested associations between stress and the individual components related to the metabolic syndrome. RESEARCH DESIGN AND METHODS This was a population-based, random sample of 3,407 women and men aged 18–78 years residing in Western Finland. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III and International Diabetes Federation criteria. The severity of 15 stressful life events pertaining to finance, work, social relationships, health, and housing was self-rated. RESULTS In comparison with subjects not reporting any extremely stressful life events, those reporting work- or finance-related events had an increased odds for having the metabolic syndrome. The risk was further increased according to accumulation of stressful finance-related events and to having at least three stressful life events in any of the life domains assessed. Accumulation of stressful life events was associated with insulin resistance, obesity, and triglycerides. The associations were not confounded by sex, age, lifestyle, or family history of diabetes. CONCLUSIONS Life events perceived as stressful, particularly those related to finance and work, may be a signal for poor metabolic health.
SNF1-Related Protein Kinases Type 2 Are Involved in Plant Responses to Cadmium Stress1[C][W]

Cadmium ions are notorious environmental pollutants. To adapt to cadmium-induced deleterious effects plants have developed sophisticated defense mechanisms. However, the signaling pathways underlying the plant response to cadmium are still elusive. Our data demonstrate that SnRK2s (for SNF1-related protein kinase2) are transiently activated during cadmium exposure and are involved in the regulation of plant response to this stress. Analysis of tobacco (Nicotiana tabacum) Osmotic Stress-Activated Protein Kinase activity in tobacco Bright Yellow 2 cells indicates that reactive oxygen species (ROS) and nitric oxide, produced mainly via an l-arginine-dependent process, contribute to the kinase activation in response to cadmium. SnRK2.4 is the closest homolog of tobacco Osmotic Stress-Activated Protein Kinase in Arabidopsis (Arabidopsis thaliana). Comparative analysis of seedling growth of snrk2.4 knockout mutants versus wild-type Arabidopsis suggests that SnRK2.4 is involved in the inhibition of root growth triggered by cadmium; the mutants were more tolerant to the stress. Measurements of the level of three major species of phytochelatins (PCs) in roots of plants exposed to Cd2+ showed a similar (PC2, PC4) or lower (PC3) concentration in snrk2.4 mutants in comparison to wild-type plants. These results indicate that the enhanced tolerance of the mutants does not result from a difference in the PCs level. Additionally, we have analyzed ROS accumulation in roots subjected to Cd2+ treatment. Our data show significantly lower Cd2+-induced ROS accumulation in the mutants’ roots. Concluding, the obtained results indicate that SnRK2s play a role in the regulation of plant tolerance to cadmium, most probably by controlling ROS accumulation triggered by cadmium ions.
Musculoskeletal Atrophy in an Experimental Model of Knee Osteoarthritis: The Effects of Exercise Training and Low-Level Laser Therapy

ObjectiveThe aim of this study was to evaluate the effects of an exercise training protocol and low-level laser therapy (and the association of both treatments) on musculoskeletal atrophy using an experimental model of knee osteoarthritis (OA). DesignFifty male Wistar rats were randomly divided into five groups: control group, knee OA control group, OA plus exercise training group, OA plus low-level laser therapy group, and OA plus exercise training associated with low-level laser therapy group. The exercise training and the laser irradiation started 4 wks after the surgery, 3 days per week for 8 wks. The exercise was performed at a speed of 16 m/min, 3 days per week, 50 mins per day, for 8 wks. Laser irradiation was applied at two points of the left knee joint (medial and lateral), for 24 sessions. ResultsThe results showed that both trained groups (irradiated or not) presented a significant increase in the muscle cross-sectional area and a decrease in muscle fiber density compared with the knee OA control group. Moreover, both trained and laser-irradiated groups demonstrated decreased muscle-specific ring-finger protein 1 and atrogin-1 immunoexpression. ConclusionsThese results suggest that exercise training and low-level laser therapy were effective in preventing musculoskeletal alterations related to atrophy caused by the degenerative process induced by knee OA.
Quality of drug label information on QT interval prolongation.

BACKGROUND Information regarding QT-prolongation in the drug label may vary between products. This could lead to suboptimal risk minimization strategies. OBJECTIVE To systematically assess the variation in the extent and content of information on QT prolongation in the summary of product characteristics (SPC) of recently approved medicinal products. METHODS Drug labels of products centrally approved in Europe between 2006 and 2012 were screened. Of drugs including the term 'QT' in the SPC, the message on QT-prolongation ('no prolongation'/'unclear drug-QT association'/'possibly QT-prolongation'/'QT-prolongation') and the advice on cautionary measures pertaining to QT-prolongation in the label were examined, as well as their association. RESULTS Of the 175 screened products, 44 contained information on QT in the SPC ('no QT-prolongation': 23%, 'unclear drug-QT association': 43%, 'possibly QT-prolongation': 16%, 'QT-prolongation': 18%). 62% contained advices to act with caution in patients with additional risk factors for QT-prolongation. Products that more likely to have QT-prolonging properties according to the SPC provided more information on QT-prolongation in the SPC ('no prolongation': 10% and for the category 'QT-prolongation': 100%). CONCLUSIONS The extent and content of information on QT-prolongation varies considerably between SPCs, and in almost half of the drugs a clear message on QT-prolongation was lacking in the SPC.
Efficient Graph-based Image Matching for Recognition and Retrieval

(cid:151)Graphs can be used for effective representation of images for recognition and retrieval purposes. The problem is often to (cid:2)nd a proper structure that can ef(cid:2)ciently describe an image and can be matched in reasonably low computational expense. The standard solutions to the graph matching problem are computationally expensive since the search space involves all permutations of the nodesets. We compare two graphical representations called the Nearest-Neighbor Graphs and the Collocation Trees, for the goodness of (cid:2)t and the computational expense involved in matching. Various schemes to index the graphical structures have also been discussed.
Growth failure.

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Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is familial in 10% of cases. We have identified a missense mutation in the gene encoding fused in sarcoma (FUS) in a British kindred, linked to ALS6. In a survey of 197 familial ALS index cases, we identified two further missense mutations in eight families. Postmortem analysis of three cases with FUS mutations showed FUS-immunoreactive cytoplasmic inclusions and predominantly lower motor neuron degeneration. Cellular expression studies revealed aberrant localization of mutant FUS protein. FUS is involved in the regulation of transcription and RNA splicing and transport, and it has functional homology to another ALS gene, TARDBP, which suggests that a common mechanism may underlie motor neuron degeneration.
TRPC6 Contributes to the Ca2+ Leak of Human Erythrocytes

Human erythrocytes express cation channels which contribute to the background leak of Ca2+, Na+ and K+. Excessive activation of these channels upon energy depletion, osmotic shock, Cl- depletion, or oxidative stress triggers suicidal death of erythrocytes (eryptosis), characterized by cell-shrinkage and exposure of phosphatidylserine at the cell surface. Eryptotic cells are supposed to be cleared from circulating blood. The present study aimed to identify the cation channels. RT-PCR revealed mRNA encoding the non-selective cation channel TRPC6 in erythroid progenitor cells. Western blotting indicated expression of TRPC6 protein in erythrocytes from man and wildtype mice but not from TRPC6-/- mice. According to flow-cytometry, Ca2+ entry into human ghosts prepared by hemolysis in EGTA-buffered solution containing the Ca2+ indicator Fluo3/AM was inhibited by the reducing agent dithiothreitol and the erythrocyte cation channel blockers ethylisopropylamiloride and amiloride. Loading of the ghosts with antibodies against TRPC6 or TRPC3/6/7 but neither with antibodies against TRPM2 or TRPC3 nor antibodies pre-adsorbed with the immunizing peptides inhibited ghost Ca2+ entry. Moreover, free Ca2+ concentration, cell-shrinkage, and phospholipid scrambling were significantly lower in Cl--depleted TRPC6-/- erythrocytes than in wildtype mouse erythrocytes. In conclusion, human and mouse erythrocytes express TRPC6 cation channels which participate in cation leak and Ca2+-induced suicidal death.
Haptics in minimally invasive surgery – a review

This article gives an overview of research performed in the field of haptic information feedback during minimally invasive surgery (MIS). Literature has been consulted from 1985 to present. The studies show that currently, haptic information feedback is rare, but promising, in MIS. Surgeons benefit from additional feedback about force information. When it comes to grasping forces and perceiving slip, little is known about the advantages additional haptic information can give to prevent tissue trauma during manipulation. Improvement of haptic perception through augmented haptic information feedback in MIS might be promising.
Molecular and Cellular Pathobiology Integrin-Free Tetraspanin CD 151 Can Inhibit Tumor Cell Motility uponClustering and Is aClinical Indicator of Prostate Cancer Progression

Normal physiology relies on the organization of transmembrane proteins by molecular scaffolds, such as tetraspanins. Oncogenesis frequently involves changes in their organization or expression. The tetraspanin CD151 is thought to contribute to cancer progression through direct interaction with the laminin-binding integrins a3b1 anda6b1.However, this interaction cannot explain the ability ofCD151 to controlmigration in the absence of these integrins or on non-laminin substrates. We demonstrate that CD151 can regulate tumor cell migration without direct integrin binding and that integrin-free CD151 (CD151) correlates clinically with tumor progression and metastasis. Clustering CD151 through its integrin-binding domain promotes accumulation in areas of cell–cell contact, leading to enhanced adhesion and inhibition of tumor cell motility in vitro and in vivo. CD151 clustering is a strong regulator ofmotility even in the absence ofa3 expression but requires PKCa, suggesting that CD151 can control migration independent of its integrin associations. The histologic detection of CD151 in prostate cancer correlates with poor patient outcome. When CD151 is present, patients are more likely to recur after radical prostatectomy and progression to metastatic disease is accelerated. Multivariable analysis identifies CD151 as an independent predictor of survival.Moreover, thedetectionof CD151 can stratify survival amongpatientswith elevated prostate-specific antigen levels. Cumulatively, these studies demonstrate that a subpopulation of CD151 exists on the surface of tumor cells that can regulate migration independent of its integrin partner. The clinical correlation of CD151 with prostate cancer progression suggests that itmay contribute to the disease and predict cancer progression. Cancer Res; 74(1); 173–87. 2013 AACR.
Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics.

Most protein kinases phosphorylate multiple substrates, each of which induces different and sometimes opposing functions. Determining the role of phosphorylation of each substrate following a specific stimulus is challenging but is essential to elucidate the role of that substrate in the signaling event. Here we describe a rational approach to identify inhibitors of delta protein kinase C (δPKC), each inhibiting the phosphorylation of only one of δPKC's substrates. δPKC regulates many signaling events and we hypothesized that a docking inhibitor of a given substrate to δPKC should selectively abrogate the phosphorylation of only that substrate, without affecting the phosphorylation of the other δPKC substrates. Here we report the development of selective inhibitors of three δPKC substrates (in vitro Kd ≈3 nm); two greatly reduced ischemia-induced cardiac injury with an IC50 of ≈200 nm and the third had no effect, indicating that its respective substrate phosphorylation by δPKC has no role in the response to cardiac ischemia and reperfusion. The three inhibitors are highly specific; even at 1 μm, the phosphorylation of other δPKC protein substrates was unaffected. The rationale we describe is likely applicable for the development of other substrate-specific inhibitors as well.