Miracle-dz/UniFAR-FTUs huggingface dataset:
Differentiating Pancreatic Ductal Adenocarcinoma from Pancreatic Serous Cystadenoma, Mucinous Cystadenoma, and a Pseudocyst with Detailed Analysis of Cystic Features on CT Scans: a Preliminary Study

Objective To determine whether or not detailed cystic feature analysis on CT scans can assist in the differential diagnosis of pancreatic ductal adenocarcinoma (PDAC) from serous cystadenoma (SCN), mucinous cystadenoma (MCN), and a pseudocyst. Materials and Methods This study received Institutional Review Board approval and informed patient consent was waived. Electronic radiology and pathology databases were searched to identify patients with PDAC (n = 19), SCN (n = 26), MCN (n = 20) and a pseudocyst (n = 23) who underwent pancreatic CT imaging. The number, size, location, and contents of cysts, and the contour of the lesions were reviewed, in addition to the wall thickness, enhancement patterns, and other signs of pancreatic and peripancreatic involvement. Diagnosis was based on lesion resection (n = 82) or on a combination of cytological findings, biochemical markers, and tumor markers (n = 6). Fisher's exact test was used to analyze the results. Results A combination of the CT findings including irregular contour, multiple cysts, mural nodes, and localized thickening, had a relatively high sensitivity (74%) and specificity (75%) for differentiating PDAC from SCN, MCN, and pseudocysts (p < 0.05). Other CT findings such as location, greatest dimension, or the presence of calcification were not significantly different. Conclusion The CT findings for PDAC are non-specific, but perhaps helpful for differentiation. PDAC should be included in the general differential diagnosis of pancreatic cystic neoplasms.
Impact des activités synaptiques endogènes sur l'excitabilité cellulaire et le traitement sensoriel cortical : apports de l'état isoélectrique

Le cerveau genere spontanement des activites electriques enregistrables a toutes les echelles spatiales, de l'electroencephalogramme (EEG) jusqu'a la membrane neuronale. La frequence et l'amplitude de ces activites varient en fonction des etats de vigilance. Afin de comprendre comment cette activite synaptique endogene sculpte a chaque instant l'integration des evenements exogenes, j'ai mis au point une nouvelle strategie experimentale in vivo visant a comparer les reponses neuronales a divers stimuli, en presence et en absence d'activite endogene. J'ai genere, chez le rat, une activite de type eveil ou sommeil puis, j'ai induit un etat isoelectrique durant lequel toute activite spontanee etait supprimee. J'ai montre que la suppression de l'activite synaptique dans les neurones du cortex somatosensoriel induisait une diminution de sensibilite neuronale et un accroissement de la regularite des reponses. La persistance d'une excitabilite neuronale dans cet etat de coma profond m'a conduit a poursuivre mes recherches avec le service de reanimation neurologique afin d'explorer, chez des patients places dans un tel coma, la reactivite corticale a des stimulations sensorielles. J'ai demontre chez l'homme et l'animal la persistance de potentiels evoques sensoriels dans l'EEG et les neurones corticaux. Ces reponses apparaissaient plus tardivement, avec une amplitude plus importante et une plus grande fiabilite d'un essai a l'autre. Ainsi, il apparait que l'activite synaptique spontanee, qui caracterise le fonctionnement " normal " du cerveau, a essentiellement comme effet d'augmenter la sensibilite des neurones ainsi que la variabilite statistique des reponses a l'environnement.
Please Scroll down for Article the Effect of Emotion-focused Orientation at Retrieval on Emotional Memory in Young and Older Adults

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Cell-to-cell variability and robustness in S-phase duration from genome replication kinetics

Abstract Genome replication, a key process for a cell, relies on stochastic initiation by replication origins, causing a variability of replication timing from cell to cell. While stochastic models of eukaryotic replication are widely available, the link between the key parameters and overall replication timing has not been addressed systematically. We use a combined analytical and computational approach to calculate how positions and strength of many origins lead to a given cell-to-cell variability of total duration of the replication of a large region, a chromosome or the entire genome. Specifically, the total replication timing can be framed as an extreme-value problem, since it is due to the last region that replicates in each cell. Our calculations identify two regimes based on the spread between characteristic completion times of all inter-origin regions of a genome. For widely different completion times, timing is set by the single specific region that is typically the last to replicate in all cells. Conversely, when the completion time of all regions are comparable, an extreme-value estimate shows that the cell-to-cell variability of genome replication timing has universal properties. Comparison with available data shows that the replication program of three yeast species falls in this extreme-value regime.
Regeneration of Lesioned Corticospinal Tract Fibers in the Adult Rat Induced by a Recombinant, Humanized IN-1 Antibody Fragment

Axons in the CNS of higher vertebrates generally fail to regenerate after injury. This lack of regeneration is crucially influenced by neurite growth inhibitory protein constituents of CNS myelin. We have shown previously that a monoclonal antibody (mAb IN-1) capable of binding and neutralizing Nogo-A, a myelin-associated inhibitor of neurite growth, can induce long-distance axonal regeneration and increased structural plasticity with improved functional recovery in rat models of CNS injury. In this paper we demonstrate that a partially humanized, recombinant Fab fragment (rIN-1 Fab) derived from the original mAb IN-1, was able to promote long-distance regeneration of injured axons in the spinal cord of adult rats. When infused into a spinal cord injury site, regrowth of corticospinal fibers in 11 of 18 animals was observed after a survival time of 2 weeks. Regenerating fibers grew for >9 mm beyond the lesion site and arborized profusely in the distal cord. Regenerated fibers formed terminal arbors with varicosities in the spinal cord gray matter, strongly resembling synaptic points of contact to neurons in the spinal cord distal to the lesion. In animals that had received a bovine serum albumin solution or a recombinant IN-1 fragment that had been mutated in the antigen binding site (mutIN-1 Fab), no significant growth beyond normal lesion-induced sprouting was observed. Neutralization of endogenous nerve growth inhibitors represents a novel use of recombinant antibody technology with potential therapeutic applications after traumatic CNS lesions.
Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

Thrombospondin (TSP) forms specific complexes with transforming growth factor-beta (TGF-beta) in the alpha granule releasate of platelets and these TSP-TGF-beta complexes inhibit the growth of bovine aortic endothelial cells (BAE). In these studies, we report that TSP stripped of associated TGF-beta (sTSP) retained growth inhibitory activity which was partially reversed by a neutralizing antibody specific for TGF- beta. Since BAE cells secrete latent TGF-beta, we determined whether sTSP activates the latent TGF-beta secreted by BAE cells. Cells were cultured with or without sTSP and then the conditioned medium was tested for the ability to support TGF-beta-dependent normal rat kidney (NRK) colony formation in soft agar. Medium conditioned with sTSP showed a dose- and time-dependent ability to stimulate BAE-secreted TGF- beta activity, reaching maximal activation by 1-2 h with 0.4 micrograms/ml (0.9 nM) sTSP. The sTSP-mediated stimulation of TGF-beta activity is not dependent on serum factors and is not a general property of extracellular matrix molecules. The sTSP-mediated stimulation of TGF-beta activity was blocked by a mAb specific for sTSP and by neutralizing antibodies to TGF-beta. Activation of BAE cell secreted latent TGF-beta by sTSP can occur in the absence of cells and apparently does not require interactions with cell surface molecules, since in conditioned medium removed from cells and then incubated with sTSP, activation occurs with kinetics and at levels similar to what is seen when sTSP is incubated in the presence of cells. Serine proteases such as plasmin are not involved in sTSP-mediated activation of TGF- beta. Factors that regulate the conversion of latent to active TGF-beta are keys to controlling TGF-beta activity. These data suggest that TSP is a potent physiologic regulator of TGF-beta activation.
The State of Organizational Reform in European Firms: Evidence from a Comparative Overview of Ten EU Countries

Based on some recent surveys, the paper is intended to offer an overview of the diffusion of organisational change in European firms and their effects in terms of performance and impact on employment. Taking into account the differences in national industrial relation systems in which the changes have taken place, contrasted "national" trajectories are exhibited. Three "models" of diffusion are thus highlighted. The main conclusion of the paper is that - in spite of positive effects in terms of performance - the process of organizational change in the European firms is still timid and carried on under strict managerial control.
Research on Robustness Recognition Algorithms in Augmented Reality

In order to solve the issues of robustness recognition in ARToolkit system, this paper focuses on two main factors: illumination and motion. Firstly, a self-adaptive illumination algorithm is proposed based on the analysis of previous work. By establishing relationship between illumination and grayscale threshold, the algorithm can dynamically adjust the grayscale threshold, thus effectively improve the robustness recognition in ARToolkit applications. Secondly, the method of optical flow tracking algorithm is proposed, which can maintain the robustness of recognition when the object is moving. Consequently, the ideal experimental results show that algorithms are effective and feasible.
Regulation of Serotonin Biosynthesis by the G Proteins Gαo and Gαq Controls Serotonin Signaling in Caenorhabditis elegans

To analyze mechanisms that modulate serotonin signaling, we investigated how Caenorhabditis elegans regulates the function of serotonergic motor neurons that stimulate egg-laying behavior. Egg laying is inhibited by the G protein Gαo and activated by the G protein Gαq. We found that Gαo and Gαq act directly in the serotonergic HSN motor neurons to control egg laying. There, the G proteins had opposing effects on transcription of the tryptophan hydroxylase gene tph-1, which encodes the rate-limiting enzyme for serotonin biosynthesis. Antiserotonin staining confirmed that Gαo and Gαq antagonistically affect serotonin levels. Altering tph-1 gene dosage showed that small changes in tph-1 expression were sufficient to affect egg-laying behavior. Epistasis experiments showed that signaling through the G proteins has additional tph-1-independent effects. Our results indicate that (1) serotonin signaling is regulated by modulating serotonin biosynthesis and (2) Gαo and Gαq act in the same neurons to have opposing effects on behavior, in part, by antagonistically regulating transcription of specific genes. Gαo and Gαq have opposing effects on many behaviors in addition to egg laying and may generally act, as they do in the egg-laying system, to integrate multiple signals and consequently set levels of transcription of genes that affect neurotransmitter release.
Housing Demand during the Boom: The Role of Expectations and Credit Constraints

I use a life-cycle model of housing demand to infer expectations about house prices and home equity requirements for the housing boom of the 2000s from observed household choices. Expectations and credit constraints are separately identified from the intensive and extensive margins of housing demand. The main results are that (1) expected price growth was close to average long-run growth, (2) home equity requirements were lax initially, but tightened after the bust, and (3) subjective uncertainty about future price growth was large. Given the option to default on mortgage debt, greater price uncertainty leads to higher optimal household leverage.
What Language Does Your Internal Working Model of Attachment Speak?

Nonnative English speakers are a growing population in the United States and United Kingdom, yet nothing is known about how second-language interviewing affects the assessment (or classification) of internal working models (IWM) of attachment. We suggest that these assessments may be subject to deleterious effects when conducted in an individual’s second language, because they (and the IWM structure itself) are linguistically bound, emotionally laden, and complicated by cultural loading. In this review, research regarding how the language of assessment broadly affects language production, interview content, emotional expression, and interviewee behavior is reviewed. We close with areas for future research and a table of existing attachment assessments by language in an effort to spur cross-cultural and bilingual research in this area. This review can therefore serve as a resource for clinicians wishing to assess attachment with linguistically diverse clients and researchers wishing to address the basic question of this review—how is the assessment of IWMs affected when conducted in an individual’s nonnative tongue?
Nber Working Paper Series the Labor Market Consequences of Financial Crises with or without Inflation: Jobless and Wageless Recoveries the Labor Market Consequences of Financial Crises with or without Inflation: Jobless and Wageless Recoveries

We are grateful to Victor Elias, Gaston Gelos and Ernesto Talvi for very valuable comments. The views expressed herein are those of the authors and do not necessarily reflect the views of the National Bureau of Economic Research. NBER working papers are circulated for discussion and comment purposes. They have not been peer-reviewed or been subject to the review by the NBER Board of Directors that accompanies official NBER publications. ABSTRACT This paper offers empirical evidence showing that, relative to "normal" recessions, financial crises hit the labor market by either enhancing the degree of joblessness and/or by further depressing the real wage – a situation that the paper labels "wageless recovery. " This holds for a sample of both advanced and emerging-market economies recession episodes, using credit market data prior to the recession episode as instrumental variable for financial crises. Results also indicate that inflation determines the type of recovery: low inflation is associated with jobless recovery, while high inflation is associated with wageless recovery. The paper shows that these outcomes are consistent with a simple model in which collateral requirements are higher (lower), the larger is the share of labor costs (physical capital expenditure) involved in a loan contract. This is motivated by the conjecture that if a loan becomes delinquent, physical capital is easier to confiscate than human capital. Evidence from advanced economies supports the model. An implication of these findings is that a spike of inflation during financial crisis may help to reduce jobless recoveries, but at the expense of sharply lower real wages. Only relaxing credit constraint might help both unemployment and wages.
Compensation Consultants and CEO Pay

The study examines the practice of employing multiple compensation consultants. Examining data of a sample of UK companies over the period 2003–2006 we find that CEOs receive higher equity-based pay when firms employ more than one compensation consultant. An increase in the number of compensation consultants is also associated with an increase in CEO equity-based pay, whereas no decline in CEO pay takes place when firms reduce the number of pay consultants. We also observe that the market shares of compensation consultant are positively related to CEO equity-based pay.
Evaluation of quality of life according to asthma control and asthma severity in children and adolescents

ABSTRACT OBJECTIVE: To evaluate quality of life according to the level of asthma control and degree of asthma severity in children and adolescents. METHODS: We selected children and adolescents with asthma (7-17 years of age) from the Pediatric Pulmonology Outpatient Clinic of the State University of Campinas Hospital de Clínicas, located in the city of Campinas, Brazil. Asthma control and asthma severity were assessed by the Asthma Control Test and by the questionnaire based on the Global Initiative for Asthma, respectively. The patients also completed the Paediatric Asthma Quality of Life Questionnaire (PAQLQ), validated for use in Brazil, in order to evaluate their quality of life. RESULTS: The mean age of the patients was 11.22 ± 2.91 years, with a median of 11.20 (7.00-17.60) years. We selected 100 patients, of whom 27, 33, and 40 were classified as having controlled asthma (CA), partially controlled asthma (PCA), and uncontrolled asthma (UA), respectively. As for asthma severity, 34, 19, and 47 were classified as having mild asthma (MiA), moderate asthma (MoA), and severe asthma (SA), respectively. The CA and the PCA groups, when compared with the NCA group, showed higher values for the overall PAQLQ score and all PAQLQ domains (activity limitation, symptoms, and emotional function; p < 0.001 for all). The MiA group showed higher scores for all of the PAQLQ components than did the MoA and SA groups. CONCLUSIONS: Quality of life appears to be directly related to asthma control and asthma severity in children and adolescents, being better when asthma is well controlled and asthma severity is lower.
Unwanted Sexual Contact: Students With Autism and Other Disabilities at Greater Risk

The limited literature on sexual assault and unwanted sexual contact indicates that students with disabilities, and specifically students with Autism Spectrum Disorder (ASD), are an at risk population. This study uses data from a multi-institution climate assessment to examine the prevalence of unwanted sexual contact. Findings indicate that students with non-ASD disabilities and students with ASD were twice as likely to report unwanted sexual contact, than their nondisabled peers were. Women students with ASD are particularly at risk. Implications for postsecondary institutions, recommendations for student affairs professionals, and areas for future research are discussed.
Epilepsy research: a window onto function and dysfunction of the human brain

As one of the most common neurological disorders, epilepsy has devastating behavioral, social, and occupational consequences and is associated with accumulating brain damage and neurological deficits. Epilepsy comprises a large number of syndromes, which vary greatly respect to their etiology and clinical features, but share the characteristic clinical hallmark of epilepsy recurrent spontaneous seizures. Research aimed at understanding the genetic, molecular, and cellular basis of epilepsy has to integrate various research approaches and techniques ranging from clinical expertise, functional analyses of the system and cellular levels, both in human subjects and rodent models of epilepsy, to human and mouse genetics. This knowledge may then be developed into novel treatment options with better control of seizures andlor fewer side effects. In addition, the study of epilepsy has frequently shed light on basic mechanisms underlying the function and dysfunction of the human brain.
A Time-Frequency CORRelation-Based Blind Source Separation Method for Time-Delayed Mixtures

We propose a time-frequency (TF) blind source separation (BSS) method suited to attenuated and delayed (AD) mixtures, inspired from a method that we previously developed for linear instantaneous mixtures. This approach only requires each of the uncorrelated sources to occur alone in a tiny TF zone, i.e. it sets very limited constraints on the source sparsity and overlap, unlike various previously reported TF-BSS methods. Our approach is based on time-frequency correlation (hence its name AD-TIFCORR). It consists in identifying the columns of the (filtered permuted) mixing matrix in TF zones where it detects that a single source occurs. We thus identify columns of scale coefficients and time shifts. This method is especially suited to non-stationary sources
Creating a Digital Ecosystem: Service-Oriented Architectures with Distributed Evolutionary Computing

We start with a discussion of the relevant literature, including Nature Inspired Computing as a framework in which to understand this work, and the process of biomimicry to be used in mimicking the necessary biological processes to create Digital Ecosystems. We then consider the relevant theoretical ecology in creating the digital counterpart of a biological ecosystem, including the topological structure of ecosystems, and evolutionary processes within distributed environments. This leads to a discussion of the relevant fields from computer science for the creation of Digital Ecosystems, including evolutionary computing, Multi-Agent Systems, and Service-Oriented Architectures. We then define Ecosystem-Oriented Architectures for the creation of Digital Ecosystems, imbibed with the properties of self-organisation and scalability from biological ecosystems, including a novel form of distributed evolutionary computing.
The attentional blink is attenuated for objects of expertise

ABSTRACT Perceptual expertise with a specific domain of stimuli has been shown to afford numerous benefits to information processing performance. Previous work has suggested that face perception, a domain of perceptual expertise for many, is less susceptible to one of the most robust examples of information processing limits, namely the attentional blink. Here we extend this finding to non-face objects of expertise, supporting an expertise-related account of this benefit. Further, the attenuation of the attentional blink phenomenon was correlated with expertise at an individual level, whereby greater expertise with cars yielded a smaller attentional blink for these stimuli. These results support previous work suggesting that extensive experience with a class of objects, such as in the case of perceptual experts, can reduce the consequence of inherent limitations in human information processing. Possible mechanistic accounts of how experience may circumvent processing limitations are discussed.