Miracle-dz/UniFAR-FTUs huggingface dataset:
Reproducibility and validity of an FFQ developed for the Korea National Health and Nutrition Examination Survey (KNHANES)

Abstract Objective We aimed to evaluate the reproducibility and validity of the newly developed FFQ for the Korean National Health and Nutrition Examination Survey (KNHANES) and to estimate the measure’s calibration factors. Design The 109-item FFQ was administered twice, approximately 9 months apart. We also collected four seasonal 3 d dietary records (DR) as a reference method. Correlation coefficients and joint classification were computed to compare intakes of energy, thirteen nutrients and eleven food groups between the two FFQ to evaluate reproducibility. For validity, de-attenuated and energy-adjusted correlation, joint classification and Bland–Altman statistics were calculated for energy and nutrients between the first FFQ and the DR. To calibrate the FFQ, we performed a linear regression analysis in which the DR were the dependent variables and FFQ, age and sex were the independent variables. Setting Seoul metropolitan area, Republic of Korea. Subjects A total of 126 adults aged 20–65 years. Results The average correlation coefficients measuring reproducibility were 0·54 for nutrients and 0·57 for food groups. The mean correlation coefficient measuring validity was 0·40 for all nutrients between the first FFQ and the DR. On average, 75 % of the participants were classified into the same or adjacent quartiles, while 5 % of the participants were grossly misclassified. The mean energy and nutrient intakes estimated by the calibrated FFQ were similar to the means estimated by the DR. Conclusions The newly developed FFQ for assessing dietary intake in the KNHANES has acceptable reproducibility and modest validity compared with a 12 d DR collected over a 9-month period.
Comparison of blind intubation through supraglottic devices and direct laryngoscopy by novices: a simulation manikin study

Objective This study aimed to compare intubation performance between blind intubation through supraglottic airway devices and direct laryngoscopy by novices under manikin simulation. We hypothesized that the intubation time by novices using supraglottic airway devices was superior to that with the Macintosh laryngoscope (MCL). Methods A prospective, randomized crossover study was conducted with 95 participants, to evaluate i-gel, air-Q, LMA Fastrach, and MCL devices. Primary outcomes were the intubation time and the success rate for intubation. Results The i-gel showed the shortest insertion and tube passing time among the four devices; the i-gel and air-Q also showed the shortest total intubation time (all P<0.0083; i-gel vs. air-Q, P=0.03). The i-gel and MCL showed the highest cumulative success rate (all P<0.0083; i-gel vs. MCL, P=0.12). Conclusion Blind intubation through the i-gel showed almost equal intubation performance compared to direct laryngoscopy.
Surgical Division of Labial Adhesions in Vulvar Lichen Sclerosus and Lichen Planus

Objective Vulvar lichen sclerosus (LS) and lichen planus (LP) may cause persistent symptomatic labial adhesions. In the scant literature on this topic, there is no agreement about which operation is suitable, or the role of suppressive medical therapy. We report on simple perineotomy in the context of careful preoperative and postoperative medical suppressions. Materials and Methods Thirty-five patients were identified within a referral vulvar practice, with symptomatic labial adhesions due to LS or LP. After sharp dissection of adhesions and injection of anesthesia, patients doubled the frequency of their preoperative therapy and underwent close surveillance until complete healing had occurred. Suppression of the inflammatory process was continued indefinitely with regular review. Results Mean age was 57 years. Of the patients, 27 had LS and 8 had LP. Of the 35 patients, 28 (80%) had dyspareunia or apareunia. Mean symptom duration was 9 years. Of the 35 patients, 21 had posterior fusion, 11 had anterior fusion, and 3 had both anterior and posterior fusions. Of the 35 patients, 17 had mild fusion, 11 had moderate fusion, and 7 had severe introital stenosis. At the 3-month review, 31 of the 35 patients had no refusion. Mean duration of follow-up was 2 years (range = 3 months to 7.5 years). Of the 35 patients, 29 had no late refusion during this time. Of the 18 patients with dyspareunia, 8 had no pain, and 9 had less pain. Of the 10 patients with apareunia, 1 could have sex without pain, and 6 could have sex but with pain. Conclusion Simple perineotomy is adequate to treat persistent labial adhesions, provided that the inflammatory process is carefully suppressed.
Epithelial–Mesenchymal Transition in Ovarian Carcinoma

Ovarian cancer is the most lethal gynecologic malignancy, with the majority of patients dying within 5 years of diagnosis. This poor survival of patients diagnosed with this malignancy is attributed to diagnosis at advanced stage, when the tumor has metastasized, and to chemotherapy resistance, either primary or developing along tumor progression. However, ovarian carcinomas, constituting the vast majority of ovarian cancers, additionally have unique biology, one aspect of which is the ability to co-express epithelial and mesenchymal determinants. epithelial–mesenchymal transition (EMT), a physiological process by which mesenchymal cells are formed and migrate to target organs during embryogenesis, is involved in cancer cell invasion and metastasis. However, these changes do not fully occur in ovarian carcinoma, and are even reversed in tumor cells present in malignant peritoneal and pleural effusions. This review summarizes current knowledge in this area, including the characteristics of EMT related to adhesion, transcriptional regulation and chemoresistance, and their clinical relevance, as well as the recently observed regulation of EMT by microRNA.
An Analysis of Bicycle Route Choice Preferences Using a Web-Based Survey to Examine Bicycle Facilities

In the U.S., the rise in motorized vehicle travel has contributed to serious societal, environmental, economic, and public health problems. These problems have increased the interest in encouraging non-motorized modes of travel (walking and bicycling). The current study contributes toward this objective by identifying and evaluating the importance of attributes influencing bicyclists’ route choice preferences. Specifically, the paper examines a comprehensive set of attributes that influence bicycle route choice, including: (1) bicyclists’ characteristics, (2) on-street parking, (3) bicycle facility type and amenities, (4) roadway physical characteristics, (5) roadway functional characteristics, and (6) roadway operational characteristics. The data used in the analysis is drawn from a web-based stated preference survey of Texas bicyclists. The results of the study emphasize the importance of a comprehensive evaluation of both route-related attributes and bicyclists’ demographics in bicycle route choice decisions. The empirical models indicate that travel time is the most important attribute for commuters in choosing their routes. Traffic volume, speed limit, on-street parking characteristics, bicycle route continuity, number of stop signs, red lights, and cross streets, and roadway terrain also impact bicyclists’ route choice.
Query Strategies for Evading Convex-Inducing Classifiers

Classifiers are often used to detect miscreant activities. We study how an adversary can systematically query a classifier to elicit information that allows the attacker to evade detection while incurring a near-minimal cost of modifying their intended malfeasance. We generalize the theory of Lowd and Meek (2005) to the family of convex-inducing classifiers that partition their feature space into two sets, one of which is convex. We present query algorithms for this family that construct undetected instances of approximately minimal cost using only polynomially-many queries in the dimension of the space and in the level of approximation. Our results demonstrate that nearoptimal evasion can be accomplished for this family without reverse engineering the classifier's decision boundary. We also consider general lp costs and show that near-optimal evasion on the family of convex-inducing classifiers is generally efficient for both positive and negative convexity for all levels of approximation if p = 1.
TECHNICAL NOTE - Decentralized Inventory Sharing with Asymmetric Information

We study the information asymmetry issues in a decentralized inventory-sharing system consisting of a manufacturer and two independent retailers, who privately hold demand information, noncooperatively place their orders, but cooperatively share inventories with each other. We find that although the manufacturer needs retailers' mean demand and standard deviation for her wholesale price decision, each retailer only needs to know the other retailer's demand standard deviation for his order quantity decision. However, an incentive compatibility analysis shows that retailers have incentives to share their demand information untruthfully. Although a truth-inducing scheme can be developed for a system with symmetric retailers who share information between themselves, no such scheme can be developed to ensure truth-telling to the manufacturer. Further, we develop a coordination mechanism (CIS) for the decentralized inventory-sharing system, considering information asymmetry. We show that CIS coordinates the manufacturer-retailers system and leads to an all-win situation under complete information. More importantly, CIS minimizes the value of information such that each party can obtain expected profits very close to their first-best profits even under asymmetric information and hence indirectly solves the information asymmetry problem. To our knowledge, this work is the first to study decentralized inventory sharing and its coordination considering asymmetric information.
Mapping Lower Austin Chalk Secondary Porosity Using Modern 3-D Seismic and Well Log Methods in Zavala County, Texas

Establishing fracture distribution and porosity trends is key to successful well design in a majority of unconventional plays. The Austin Chalk has historically been referred to as an unpredictable producer due to high fracture concentration and lateral variation in stratigraphy, however recent drilling activity targeting the lower Austin Chalk has been very successful. The Upper Cretaceous Austin Chalk (AC) and underlying Eagle Ford (EF) units are considered by many to act as a single hydrocarbon system, with communication between these two units largely through expulsion or dewatering fractures, extensional faults or along the AC/EF unconformity. Total porosity for the Eagle Ford is composed of a primary matrix component and secondary fracture porosity. For the Austin Chalk, the secondary porosity includes both dissolution and fracture components which complicate wireline and seismic interpretation. The current study interprets 40 square miles of modern 3D seismic data for horizons and faults using amplitude, coherence, curvature and ant tracking seismic attributes. Post stack acoustic impedance (AI) inversion is applied to the time migrated seismic volume with control from two wells; this input data is similar to that available to independent operators active in the area. Wireline acoustic impedance plotted against sonic and neutron-density porosity respectively, reveals strong correlations that allow calibration of seismic AI into primary, secondary and total porosity from which time slices and surface maps are created. Relationships are identified between porosity and geological features of interest, such as faulted and brittle zones, that may prove useful in guiding future well development in the lower Austin Chalk. Acknowledgements I would like to thank my advisor, Dr. Christopher Liner, for his advice, guidance and continued support during my time at the University of Arkansas. I would also like to thank my other committee members, Dr. Thomas (Mac) McGilvery and Robert Liner, for their insight and suggestions. I am also grateful to the Department of Geoscience of the University of Arkansas for giving me the opportunity to pursue a Master’s degree as well as financial support as a teaching assistant. I would like to thank Stephens Production Company for their donation of the data used in this investigation, Schlumberger for their donation of Petrel and Techlog, and CGG for use of HampsonRussell. To my parents, thank you for helping me be where I am today.
Regulation of Tenascin-C, a Vascular Smooth Muscle Cell Survival Factor that Interacts with the αvβ3 Integrin to Promote Epidermal Growth Factor Receptor Phosphorylation and Growth

Tenascin-C (TN-C) is induced in pulmonary vascular disease, where it colocalizes with proliferating smooth muscle cells (SMCs) and epidermal growth factor (EGF). Furthermore, cultured SMCs require TN-C for EGF-dependent growth on type I collagen. In this study, we explore the regulation and function of TN-C in SMCs. We show that a matix metalloproteinase (MMP) inhibitor (GM6001) suppresses SMC TN-C expression on native collagen, whereas denatured collagen promotes TN-C expression in a β3 integrin– dependent manner, independent of MMPs. Floating type I collagen gel also suppresses SMC MMP activity and TN-C protein synthesis and induces apoptosis, in the presence of EGF. Addition of exogenous TN-C to SMCs on floating collagen, or to SMCs treated with GM6001, restores the EGF growth response and “rescues” cells from apoptosis. The mechanism by which TN-C facilitates EGF-dependent survival and growth was then investigated. We show that TN-C interactions with αvβ3 integrins modify SMC shape, and EGF- dependent growth. These features are associated with redistribution of filamentous actin to focal adhesion complexes, which colocalize with clusters of EGF-Rs, tyrosine-phosphorylated proteins, and increased activation of EGF-Rs after addition of EGF. Cross-linking SMC β3 integrins replicates the effect of TN-C on EGF-R clustering and tyrosine phosphorylation. Together, these studies represent a functional paradigm for ECM-dependent cell survival whereby MMPs upregulate TN-C by generating β3 integrin ligands in type I collagen. In turn, αvβ3 interactions with TN-C alter SMC shape and increase EGF-R clustering and EGF-dependent growth. Conversely, suppression of MMPs downregulates TN-C and induces apoptosis.
Rosetta mission results pre-perihelion Special feature GIADA : shining a light on the monitoring of the comet dust production from the nucleus of 67 P / Churyumov-Gerasimenko

Context. During the period between 15 September 2014 and 4 February 2015, the Rosetta spacecraft accomplished the circular orbit phase around the nucleus of comet 67P/Churyumov-Gerasimenko (67P). The Grain Impact Analyzer and Dust Accumulator (GIADA) onboard Rosetta monitored the 67P coma dust environment for the entire period. Aims. We aim to describe the dust spatial distribution in the coma of comet 67P by means of in situ measurements. We determine dynamical and physical properties of cometary dust particles to support the study of the production process and dust environment modification. Methods. We analyzed GIADA data with respect to the observation geometry and heliocentric distance to describe the coma dust spatial distribution of 67P, to monitor its activity, and to retrieve information on active areas present on its nucleus. We combined GIADA detection information with calibration activity to distinguish different types of particles that populate the coma of 67P: compact particles and fluffy porous aggregates. By means of particle dynamical parameters measured by GIADA, we studied the dust acceleration region. Results. GIADA was able to distinguish different types of particles populating the coma of 67P: compact particles and fluffy porous aggregates. Most of the compact particle detections occurred at latitudes and longitudes where the spacecraft was in view of the comet’s neck region of the nucleus, the so-called Hapi region. This resulted in an oscillation of the compact particle abundance with respect to the spacecraft position and a global increase as the comet moved from 3.36 to 2.43 AU heliocentric distance. The speed of these particles, having masses from 10−10 to 10−7 kg, ranged from 0.3 to 12.2 m s−1. The variation of particle mass and speed distribution with respect to the distance from the nucleus gave indications of the dust acceleration region. The influence of solar radiation pressure on micron and submicron particles was studied. The integrated dust mass flux collected from the Sun direction, that is, particles reflected by solar radiation pressure, was three times higher than the flux coming directly from the comet nucleus. The awakening 67P comet shows a strong dust flux anisotropy, confirming what was suggested by on-ground dust coma observations performed in 2008.
A COMPARISON OF THREE APPROACHES FOR ATTRIBUTING HOSPITALIZATIONS TO SPECIFIC DISEASES IN COST ANALYSES

Objectives: Calculations of healthcare costs rarely disclose the specific approach used to allocate the cost of hospitalizations by diagnosis. However, the type of approach used can have a major impact on the findings in the case of significant comorbidities. The present analyses compared three approaches for attributing Medicare DRG reimbursements (which were used as surrogates for average costs) for hospitalization by diagnosis. Methods: Medical resource utilization data from the National Hospital Discharge Survey were analyzed using each of three allocation approaches: a) attributing 100% of the cost of hospitalization to the disease when it was the first-listed diagnosis; b) attributing a portion of the cost of hospitalization to the disease, depending on its position in the list of diagnoses and the relevance of any comorbidities; and c) an incremental analysis of cost based upon the hospitalization experiences of an age and gender matched cohort. These three approaches were applied to the cost of hospitalization for chronic obstructive pulmonary disease (COPD). Results: The first approach projected 206,098 hospitalizations at $3,449 per hospitalization for a projected U.S. annual total of $711 million. The second approach projected 681,547 hospitalizations at $3,205 per hospitalization for a projected U.S. annual total of $2.2 billion. The third approach also projected 681,547 hospitalizations, but at $2,361 per hospitalization, for a projected U.S. annual total of $1.6 billion. Conclusions: Expanding from the example on COPD, the limitations of each approach are described and their applications to other conditions are presented.
The GRIM2005 Study of Migraine Consultation in France II. Psychological Factors Associated with Treatment Response to Acute Headache Therapy and Satisfaction in Migraine

The objective of this analysis was to identify variables associated with treatment response in subjects with migraine. Data were collected from a sample of 10 000 subjects. A battery of questionnaires assessing clinical and psychological variables was completed. Migraine diagnosis was attributed using an algorithm based on the IHS criteria and treatment response using the ANAES criteria. We identified 1534 subjects, of whom 1443 were treated. For 54.2%, at least one ANAES criterion for treatment response was unfulfilled. Non-response was associated with female gender, high HIT-6 impact scores and high HAD psychological distress scores. The strongest associations with non-response were identified for four psychological variables: elevated scores on the CSQ catastrophization subscale and the ‘Consequences’ and ‘Acceptance’ dimensions of the Brief COPE, and low scores on the ‘Positive Reinterpretation’ Brief COPE dimension. In conclusion, many individuals with migraine respond inadequately to treatment. Behavioural interventions aimed at modifying coping strategies may improve outcome.
Association Between Socioeconomic Status and Functional Impairment 3 Months After Ischemic Stroke: The Berlin Stroke Register

Background and Purpose— We aimed to analyze the association between patient socioeconomic status and functional impairment 3 months after ischemic stroke and to identify factors that influence this association. Methods— Data were obtained from the Berlin Stroke Register, a network of 14 stroke units in Berlin. Ischemic stroke patients consecutively admitted to 1 of the hospitals in the Berlin Stroke Register between June 2010 and September 2011, were followedup 3 months after the index event by postal or telephone interview. We used multivariable logistic regression to examine the association between highest education as marker of socioeconomic status and functional impairment after stroke defined by Barthel Index categories. We adjusted for age, sex, prestroke dependency, stroke severity, functional deficit after stroke onset, and comorbidities as possible confounding factors. Results— A total of 1688 ischemic stroke patients who were alive at 3 months and completed the questionnaire were included in the analysis; 40% of the patients were female and 50% of the patients were 70 years or older. Age, prestroke dependency, stroke severity, and the absence of comorbidities were significantly associated with good functional outcome at 3 months. In multivariable analysis, a higher probability of good outcome was observed in patients with college or university degree (odds ratio, 2.18; 95% confidence interval, 1.39–3.42) compared with patients with no completed education. Conclusion— Patients with lower education have considerably lower rates of good functional outcome after stroke that cannot be fully explained by variations in the patients’ clinical and demographic characteristics.
Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UK

OBJECTIVE To study the epidemiology of pyridoxine dependent seizures and other forms of pyridoxine responsive seizures. DESIGN Monthly notifications to the British Paediatric Surveillance Unit over two years. Questionnaire follow up. SETTING UK and the Republic of Ireland. PATIENTS Children aged 15 years or younger whose seizures respond to pyridoxine. INTERVENTIONS None. MAIN OUTCOME MEASURES Numbers of children with definite, probable, and possible pyridoxine dependent seizures or other seizures responsive to pyridoxine. RESULTS Point prevalence and birth incidence: 1/687 000 and 1/783 000, respectively (definite and probable cases); 1/317 000 and 1/157 000, respectively (all types of pyridoxine responsiveness). NOTIFICATIONS Pyridoxine dependency: 14 definite, 9 probable, and 10 possible cases; neonatal seizures not meeting case definitions: 7; infantile spasms: 5. Eight of 18 families of definite/probable cases had 2 affected siblings. Just over a third had atypical presentations and just under a third had features and/or initial diagnoses of birth asphyxia and neonatal hypoxic ischaemic encephalopathy. CONCLUSIONS Pyridoxine dependency is rare. Atypical presentations are relatively frequent. A trial of pyridoxine is justified in all cases of early onset intractable seizures or status epilepticus, whatever the suspected cause. Key messages Almost a third of neonatal cases of pyridoxine dependency present with apparent birth asphyxia and/or suspected hypoxic−ischaemic encephalopathy All children with early onset (younger than 3 years old) intractable seizures or status should receive a trial of pyridoxine, whatever the suspected cause