Miracle-dz/UniFAR-FTUs huggingface dataset:
Fomin-Zelevinsky mutation and tilting modules over Calabi-Yau algebras

We say that an algebra $\Lambda$ over a commutative noetherian ring $R$ is Calabi-Yau of dimension $d$ ($d$-CY) if the shift functor $[d]$ gives a Serre functor on the bounded derived category of the finite length $\Lambda$-modules. We show that when $R$ is $d$-dimensional local Gorenstein the $d$-CY algebras are exactly the symmetric $R$-orders of global dimension $d$. We give a complete description of all tilting modules of projective dimension at most one for 2-CY algebras, and show that they are in bijection with elements of affine Weyl groups, preserving various natural partial orders. We show that there is a close connection between tilting theory for 3-CY algebras and the Fomin-Zelevinsky mutation of quivers (or matrices). We prove a conjecture of Van den Bergh on derived equivalence of noncommutative crepant resolutions.
Music and movement share a dynamic structure that supports universal expressions of emotion

Music moves us. Its kinetic power is the foundation of human behaviors as diverse as dance, romance, lullabies, and the military march. Despite its significance, the music-movement relationship is poorly understood. We present an empirical method for testing whether music and movement share a common structure that affords equivalent and universal emotional expressions. Our method uses a computer program that can generate matching examples of music and movement from a single set of features: rate, jitter (regularity of rate), direction, step size, and dissonance/visual spikiness. We applied our method in two experiments, one in the United States and another in an isolated tribal village in Cambodia. These experiments revealed three things: (i) each emotion was represented by a unique combination of features, (ii) each combination expressed the same emotion in both music and movement, and (iii) this common structure between music and movement was evident within and across cultures.
Anesthesia in children with a cold.

PURPOSE OF REVIEW Common colds are infections of mostly viral origin that frequently occur in childhood. The overall anesthetic risk in children with respiratory tract infections is increased because of the increased incidence of perioperative respiratory adverse events (PRAEs). Although the morbidity and mortality of PRAE are low when managed by experienced anesthesiologists, careful preoperative assessment and perioperative anesthetic care are indispensable. RECENT FINDINGS This review summarizes recent studies to give a brief overview and background information with regard to the pathophysiological mechanisms of upper respiratory tract infections, risk factors for PRAE in children with a cold, management of anesthesia and prevention and treatment of frequently observed adverse events as well as a proposal for a decision algorithm. SUMMARY Children with a cold can be safely anesthetized under certain circumstances; however, anesthesia in children with symptomatic infections with wheezing, purulent secretion, fever and reduced general condition should be postponed for at least 2 weeks. Anesthetic treatment options for children with infection of the upper airway with a runny nose and cough include preoperative inhalational therapy with salbutamol, avoidance of endotracheal intubation whenever possible, use of a face mask or laryngeal mask, intravenous induction with propofol and avoidance of desflurane. Prevention, early recognition and immediate treatment of complications by an experienced anesthesiologist are crucial.
Sleeve lobectomy or pneumonectomy : optimal management strategy using decision analysis techniques

Modelling A decision tree model was used, with sleeve lobectomy and pneumonectomy as the options at the decision node. The model assumed that isolated local recurrences after sleeve lobectomy could be treated in a variety of ways, including reresection (completion pneumonectomy), whereas isolated local recurrences after pneumonectomy could not be treated by further resection. It was assumed that other recurrences were treated with either chemotherapy alone, or with a combination of chemotherapy and radiation therapy. It was also assumed that survival after recurrence was related to the type of recurrence and whether re-resection could be performed for an isolated local recurrence.
Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension

Background—The CYP4A11 arachidonic acid monooxygenase oxidizes endogenous arachidonic acid (AA) to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite with renovascular and tubular functions. Mice with targeted disruption of Cyp4a14, a murine homologue of CYP4A11, have severe hypertension. We combined molecular and biochemical approaches to identify a functional variant of the CYP4A11 20-HETE synthase and determine its association with hypertensive status in 2 independent human populations. Methods and Results—A thymidine-to-cytosine polymorphism at nucleotide 8590 resulted in a phenylalanine-to-serine substitution at amino acid 434. Expression of cDNA with serine 434 resulted in a protein with a significantly reduced AA and lauric acid metabolizing activity. In a population of 512 whites from Tennessee, the age, body mass index, and gender-adjusted OR of having hypertension attributable to the 8590C variant was 2.31 (95% CI 1.41 to 3.78) compared with the reference 8590TT genotype. In subjects from the Framingham Heart Study, the adjusted ORs of hypertension associated with the 8590C variant were 1.23 (CI 0.94 to 1.59; n=1538) in all subjects and 1.33 (CI 1.01 to 1.77; n=1331) when subjects with diabetes were excluded. No association of the variant with hypertension was detected in a population of 120 blacks. Conclusions—We identified a variant of the human CYP4A11 (T8590C) that encodes for a monooxygenase with reduced 20-HETE synthase activity. The association of the T8590C variant with hypertension supports its role as a polygenic determinant of blood pressure control in humans, and results obtained from the large population database suggest that the relevance of the variant may vary according to hypertension comorbidity.
Comparative study of doramectin and fipronil in the treatment of equine chorioptic mange

In equids, chorioptic mange is a common dermatitis for which there are no licensed medications in the uk. Doramectin and fipronil are licensed for the control of ectoparasites in other species and were evaluated for the treatment of 17 cases of chorioptic mange in 13 equids. Equids were included if clinical findings were indicative of chorioptic mange, chorioptes mites were positively identified and concurrent disease that could affect response to disease was not evident. A random number table was used to allocate subjects to receive doramectin (group D, eight animals) or fipronil (group F, nine animals). Each of the horses in group D were given 0·3 mg/kg doramectin (Dectomax; Pfizer) on two occasions 14 days apart by subcutaneous injection. All limbs of the horses in group F were sprayed with fipronil 0·25 per cent solution (Frontline; Merial) to the level of the stifles and elbows. Both groups were examined on the day of treatment and 14 and 28 days later to assess the behavioural signs of pruritus and the severity of the dermatological lesions. Acetate tape impressions were collected from the distal limbs and the degree of mite infestation was assessed. By day 28 there were no behavioural signs of chorioptic mange in any of the animals, and there were significant reductions in the numbers of mites in both groups. However, there were no significant reductions in the mean lesion score in either group. There was no significant difference between the effectiveness of the two treatments.
Down-regulation of Polysialic Acid Is Required for Efficient Myelin Formation*

Oligodendrocyte precursor cells modify the neural cell adhesion molecule (NCAM) by the attachment of polysialic acid (PSA). Upon further differentiation into mature myelinating oligodendrocytes, however, oligodendrocyte precursor cells down-regulate PSA synthesis. In order to address the question of whether this down-regulation is a necessary prerequisite for the myelination process, transgenic mice expressing the polysialyltransferase ST8SiaIV under the control of the proteolipid protein promoter were generated. In these mice, postnatal down-regulation of PSA in oligodendrocytes was abolished. Most NCAM-120, the characteristic NCAM isoform in oligodendrocytes, carried PSA in the transgenic mice at all stages of postnatal development. Polysialylated NCAM-120 partially co-localized with myelin basic protein and was present in purified myelin. The permanent expression of PSA-NCAM in oligodendrocytes led to a reduced myelin content in the forebrains of transgenic mice during the period of active myelination and in the adult animal. In situ hybridizations indicated a significant decrease in the number of mature oligodendrocytes in the forebrain. Thus, down-regulation of PSA during oligodendrocyte differentiation is a prerequisite for efficient myelination by mature oligodendrocytes. Furthermore, myelin of transgenic mice exhibited structural abnormalities like redundant myelin and axonal degeneration, indicating that the down-regulation of PSA is also necessary for myelin maintenance.
Cognitive Profile for Children with ADHD by Using WISC-IV : Subtype Differences ?

This study explores whether a specific cognitive profile for children with ADHD can be obtained through the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) and whether this profile is capable of differentiating between ADHD clinical subtypes. A control group of 47 children was selected, together with a clinical group of 86 children diagnosed with ADHD and divided into 2 subgroups, according to their clinical characteristics. The clinical group was characterized by a GAI > CPI with respect to the control group. The clinical subgroups did not score significantly lower in any index, but they did in the difference between the working memory index and the processing speed index. For those diagnosed with inattentive ADHD, this distance was positive; for those diagnosed with ADHD combined group, it was negative. These findings contribute empirical evidence to the hypothesis that there is a characteristic ADHD cognitive profile, with a potential ability of differentiating between ADHD clinical subtypes.
Platelet Rich Concentrate Promotes Early Cellular Proliferation and Multiple Lineage Differentiation of Human Mesenchymal Stromal Cells In Vitro

Platelet rich concentrate (PRC) is a natural adjuvant that aids in human mesenchymal stromal cell (hMSC) proliferation in vitro; however, its role requires further exploration. This study was conducted to determine the optimal concentration of PRC required for achieving the maximal proliferation, and the need for activating the platelets to achieve this effect, and if PRC could independently induce early differentiation of hMSC. The gene expression of markers for osteocytes (ALP, RUNX2), chondrocytes (SOX9, COL2A1), and adipocytes (PPAR-γ) was determined at each time point in hMSC treated with 15% activated and nonactivated PRC since maximal proliferative effect was achieved at this concentration. The isolated PRC had approximately fourfold higher platelet count than whole blood. There was no significant difference in hMSC proliferation between the activated and nonactivated PRC. Only RUNX2 and SOX9 genes were upregulated throughout the 8 days. However, protein expression study showed formation of oil globules from day 4, significant increase in ALP at days 6 and 8 (P ≤ 0.05), and increased glycosaminoglycan levels at all time points (P < 0.05), suggesting the early differentiation of hMSC into osteogenic and adipogenic lineages. This study demonstrates that the use of PRC increased hMSC proliferation and induced early differentiation of hMSC into multiple mesenchymal lineages, without preactivation or addition of differentiation medium.
ByteSlice: Pushing the Envelop of Main Memory Data Processing with a New Storage Layout

Scan and lookup are two core operations in main memory column stores. A scan operation scans a column and returns a result bit vector that indicates which records satisfy a filter. Once a column scan is completed, the result bit vector is converted into a list of record numbers, which is then used to look up values from other columns of interest for a query. Recently there are several in-memory data layout proposals that aim to improve the performance of in-memory data processing. However, these solutions all stand at either end of a trade-off --- each is either good in lookup performance or good in scan performance, but not both. In this paper we present ByteSlice, a new main memory storage layout that supports both highly efficient scans and lookups. ByteSlice is a byte-level columnar layout that fully leverages SIMD data-parallelism. Micro-benchmark experiments show that ByteSlice achieves a data scan speed at less than 0.5 processor cycle per column value --- a new limit of main memory data scan, without sacrificing lookup performance. Our experiments on TPC-H data and real data show that ByteSlice offers significant performance improvement over all state-of-the-art approaches.
Evolution of lactase persistence: an example of human niche construction

Niche construction is the process by which organisms construct important components of their local environment in ways that introduce novel selection pressures. Lactase persistence is one of the clearest examples of niche construction in humans. Lactase is the enzyme responsible for the digestion of the milk sugar lactose and its production decreases after the weaning phase in most mammals, including most humans. Some humans, however, continue to produce lactase throughout adulthood, a trait known as lactase persistence. In European populations, a single mutation (−13910*T) explains the distribution of the phenotype, whereas several mutations are associated with it in Africa and the Middle East. Current estimates for the age of lactase persistence-associated alleles bracket those for the origins of animal domestication and the culturally transmitted practice of dairying. We report new data on the distribution of −13910*T and summarize genetic studies on the diversity of lactase persistence worldwide. We review relevant archaeological data and describe three simulation studies that have shed light on the evolution of this trait in Europe. These studies illustrate how genetic and archaeological information can be integrated to bring new insights to the origins and spread of lactase persistence. Finally, we discuss possible improvements to these models.
Parakeet: a continuous speech recognition system for mobile touch-screen devices

We present Parakeet, a system for continuous speech recognition on mobile touch-screen devices. The design of Parakeet was guided by computational experiments and validated by a user study. Participants had an average text entry rate of 18 words-per-minute (WPM) while seated indoors and 13 WPM while walking outdoors. In an expert pilot study, we found that speech recognition has the potential to be a highly competitive mobile text entry method, particularly in an actual mobile setting where users are walking around while entering text.
Priming and Multiple Memory Systems: Perceptual Mechanisms of Implicit Memory

Research examining the relation between explicit and implicit forms of memory has generated a great deal of evidence concerning the issue of multiple memory systems. This article focuses on an extensively studied implicit memory phenomenon, known as direct or repetition priming, and examines the hypothesis that priming effects on various tasks reflect the operation of a perceptual representation system (PRS)a class of cortically based subsystems that operate at a presemantic level and support non conscious expressions of memory. Three PRS subsystems are examined: visual word form, structural description, and auditory word form. Pertinent cognitive, neuropsychological, and neurobiological evidence is reviewed, alternative classificatory schemes are discussed, and important conceptual and terminological issues are considered.
A compilation method for ML-style polymorphic record calculi

Polymorphic record calculi have recently attracted much attention as a typed foundation for object-oriented programming. This is based on the fact that a function that selects a field l of a record can be given a polymorphic type that enables it to be applied to various records containing a field l. Recent studies have established techniques to develop an ML-style type inference algorithm for such a polymorphic type system. There seems to be, however, no established method to compile an ML-style polymorphic record calculus into efficient code. The purpose of this paper is to present one such method. We define a polymorphic record calculus as an extension of Damas and Miler's proof system for ML. For this calculus, we define an implementation calculus where records are represented as arrays of (references to) values and field selection is performed by direct indexing. To represent polymorphic field selection, the implementation calculus contains an abstraction mechanism over indexes. We then develop an algorithm to translate the polymorphic record calculus into the implementation calculus by refining a type inference algorithm; it simultaneously computes a principal type scheme in the polymorphic record calculus and a correct implementation term in the implementation calculus. The type inference is shown to be sound and complete in the sense of Damas-Milner's algorithm for ML. Moreover, the polymorphic type system is shown to be sound with respect to an operational semantics of the translated terms in the implementation calculus.
Stability Ball Sitting Elevates Peak Arm Ergometry Oxygen Consumption and Heart Rate

This study compared sitting on a stability ball (B) to sitting on a chair (C) during arm ergometry to determine the impact on peak VO2, peak heart rate (HR), and exercise intensity prescription. Open-circuit spirometer, blood pressure, and HR were monitored during rest and continuous graded exercise test to exhaustion using an arm ergometer. Twenty-seven apparently healthy adults exercised twice, once at B and the other trial C (order randomized), with 60 minutes of rest between trials. ANOVA for repeated measures (α < 0.05) and paired t testing using Holm’s-sequential Bonferroni were used to analyze results for 30 W, 45 W, Penultimate, and Peak stages of exercise. VO2 was significantly higher (8% to 12%, P < 0.001) for all stages of exercise for B compared to C. HR was significantly higher (P < 0.001) only at the Penultimate and Peak levels (3% and 2%, respectively) for B compared to C; all other sub-maximal HRs were not significantly different. There were no significant main effects or interactions (P≥ 0.138) when VO2 and HR were expressed as percentage of maximum. Compared to chair sitting, the stability ball has a greater absolute metabolic response with little impact on HR. Prescribing exercise with absolute MET levels should consider this; however, intensity as a percentage of maximum may not be affected by the stability ball.
Evaluation of nonmemory cognitive parameters in psychiatric patients’ pre- and post-electroconvulsive therapy: An observational study

Introduction: Possibility of cognitive side effects has made electroconvulsive therapy (ECT) questionable. Variable deficits have been debated in memory cognition. Pattern of changes in nonmemory cognition pre- and post-ECT is not clear. Methodology: Forty patients undergoing ECT were studied on nonmemory cognitive parameters before ECT, after a course of ECT, and after 4 weeks of last. ECT. Results: Nonmemory cognition improved during the course of ECT and over 4 weeks of ECT. Conclusions: ECT does not affect the nonmemory cognition adversely.
Neural correlates of the behavioral-autonomic interaction response to potentially threatening stimuli

Subjective assessment of emotional valence is typically associated with both brain activity and autonomic arousal. Accurately assessing emotional salience is particularly important when perceiving threat. We sought to characterize the neural correlates of the interaction between behavioral and autonomic responses to potentially threatening visual and auditory stimuli. Twenty-five healthy male subjects underwent fMRI scanning whilst skin conductance responses (SCR) were recorded. One hundred and eighty pictures, sentences, and sounds were assessed as “harmless” or “threatening. ” Individuals' stimulus-locked, phasic SCRs and trial-by-trial behavioral assessments were entered as regressors into a flexible factorial design to establish their separate autonomic and behavioral neural correlates, and convolved to examine psycho-autonomic interaction (PAI) effects. Across all stimuli, “threatening,” compared with “harmless” behavioral assessments were associated with mainly frontal and precuneus activation with specific within-modality activations including bilateral parahippocampal gyri (pictures), bilateral anterior cingulate cortex (ACC) and frontal pole (sentences), and right Heschl's gyrus and bilateral temporal gyri (sounds). Across stimulus modalities SCRs were associated with activation of parieto-occipito-thalamic regions, an activation pattern which was largely replicated within-modality. In contrast, PAI analyses revealed modality-specific activations including right fusiform/parahippocampal gyrus (pictures), right insula (sentences), and mid-cingulate gyrus (sounds). Phasic SCR activity was positively correlated with an individual's propensity to assess stimuli as “threatening. ” SCRs may modulate cognitive assessments on a “harmless–threatening” dimension, thereby modulating affective tone and hence behavior.
Guiding the Herd: The Effect of Reference Groups in Crowdfunding Decision Making

Despite their popularity, crowdfunding platforms are experiencing negative headlines as fully funded projects continue to fail delivering the products on time. Current literature postulates that funders make decisions by following the decisions of the crowd, and this herd behavior leads to less than optimal decisions. One explanation of the negative externalities of such behavior is the misfit between the information provided by the crowd and the information needed by funders. Especially in patronage crowdfunding, funders are investors and buyers at the same time. This duality coupled with the lack of supervision of projects creates unique challenges. In addition to opportunism uncertainty, funders face competence uncertainty. This study provides evidence that social information gathered from reference groups decrease these uncertainties. Further investigation showed that different reference groups provide different types of social information and product complexity plays a role in the uncertainties experienced and the importance given to different reference groups.
Putting the Fear Back Again (and Within Individuals): Revisiting the Role of Fear in Persuasion

ABSTRACT The overwhelming majority of fear appeal research came from the between-individuals approach and yielded consistent evidence for a linear fear–persuasion relationship. A recent review suggested that the within-individuals approach might be more appropriate. Studies that measured fear at multiple time points have consistently revealed a curvilinear association between fear and persuasion predicted by the drive model. A Web-based experiment (N = 454) using tobacco warning labels was conducted to replicate the inverted-U shape curvilinear relationship between fear and persuasion, and to revisit the role of fear in fear appeal theories. Results showed that the inverted-U fear curve positively predicted persuasion and reduced maladaptive responses, and that the linear trajectory of fear positively predicted maladaptive responses and failure of persuasion.