Miracle-dz/UniFAR-FTUs huggingface dataset:
A risk‐ranking methodology for prioritizing historic, potentially contaminated mine sites in British Columbia

The Crown Land Restoration Branch (CLRB) of the British Columbia Ministry of Agriculture and Lands is responsible for managing thousands of historic and abandoned mine sites on provincial lands (referred to as Crown Contaminated Sites). For most of these sites, there is limited information available regarding the extent of potential contamination or potential human health and ecological risks. Given the large number of sites, the CLRB sought a system for prioritizing investigation and management efforts among them. We developed a Risk‐Ranking Methodology (RRM) to meet this objective, which was implemented in 2007/2008 with an emphasis on historic mine sites because of the significant number of sites and related potential risk. The RRM uses a risk‐based Preliminary Site Investigation to gather key information about the sites. The information for each site is analyzed and summarized according to several attributes aimed at characterizing potential health and ecological risks. The summary information includes, but is not limited to, generic comparisons of exposure with effects levels (screening quotients) for human and ecological exposure pathways. The summary information (more than 25 attributes) is then used in a workshop setting to evaluate relative rankings among sites, and also to identify subsequent management actions for each site. Application of the RRM in 2007/2008 was considered successful, because there was confidence in the process, the content and the outputs. A key challenge was keeping the number of attributes to a manageable level. Ranking was based on discussion and consensus, which was a feasible approach given the relatively small number of sites that need to be ranked each year, and facilitated transparency in the ranking process. We do not rule out the future possibility of developing a quantitative function to capture trade‐offs among attributes. Integr Environ Assess Manag 2010; 6:145–154. © 2009 SETAC
Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes

The antitumor agent bryostatin 1 and the tumor-promoting phorbol esters function as structural mimetics of the second lipid messenger diacylglycerol (DAG) by binding to the C1 domain of DAG receptors. However, bryostatin 1 and the phorbol esters often differ in their cellular actions. In mouse skin, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is a potent tumor promoter, whereas bryostatin 1 lacks this activity and antagonizes the tumor-promoting effects of TPA. Although protein kinase C mediates many of the effects of DAG on skin, the exact mechanisms responsible for the biology of bryostatin 1 and TPA in the epidermis have not been elucidated. We recently reported that the novel DAG receptor RasGRP1 is expressed in mouse keratinocytes and mediates TPA-induced Ras activation. This finding prompted us to examine the regulation of RasGRP1 by bryostatin 1. We found that whereas TPA induced translocation of RasGRP1 to both the plasma and internal membranes of the keratinocytes, bryostatin 1 recruited RasGRP1 only to internal membranes and the nuclear envelope. In addition, TPA led to a concentration-dependent down-regulation of RasGRP1, whereas bryostatin 1 failed to induce full RasGRP1 down-regulation. Interestingly, bryostatin 1 was less effective than TPA at activating Ras. The results presented here suggest the possibility that a differential modulation of RasGRP1 by bryostatin 1 compared with TPA could participate in the disparate responses of the epidermal cells to both DAG analogues. This result may have implications in the understanding of the antitumor effects of bryostatin 1 in the skin. [Mol Cancer Ther 2006;5(3):602–10]
Accurate Semantic Class Classifier for Coreference Resolution

There have been considerable attempts to incorporate semantic knowledge into coreference resolution systems: different knowledge sources such as WordNet and Wikipedia have been used to boost the performance. In this paper, we propose new ways to extract WordNet feature. This feature, along with other features such as named entity feature, can be used to build an accurate semantic class (SC) classifier. In addition, we analyze the SC classification errors and propose to use relaxed SC agreement features. The proposed accurate SC classifier and the relaxation of SC agreement features on ACE2 coreference evaluation can boost our baseline system by 10.4% and 9.7% using MUC score and anaphor accuracy respectively.
The Collateral Channel: How Real Estate Shocks Affect Corporate Investment

What is the impact of real estate prices on corporate investment? In the presence of financing frictions, firms use pledgeable assets as collateral to finance new projects. Through this collateral channel, shocks to the value of real estate can have a large impact on aggregate investment. Over the 1993-2007 period, the representative U.S. corporation invests 6 cents out of each additional dollar of collateral. To compute this sensitivity, we use local variations in real estate prices as shocks to the collateral value of firms that own real estate. We address the endogeneity of local real estate prices using the interaction of interest rates and local constraints on land supply as an instrument. We address the endogeneity of the decision to own land (1) by controlling for observable determinants of ownership and (2) by looking at the investment behavior of firms before and after they acquire land. The sensitivity of investment to collateral value is stronger the more likely a firm is to be credit constrained.
Arc Statistics in Cosmological Models with Dark Energy

We investigate how the probability of the formation of giant arcs in galaxy clusters is expected to change in cos- mological models dominated by dark energy with an equation of state p = wρc 2 compared to cosmological-constant or open models. To do so, we use a simple analytic model for arc cross sections based on the Navarro-Frenk-White density profile which we demonstrate reproduces essential features of numerically determined arc cross sections. Since analytic lens models are known to be inadequate for accurate absolute quantifications of arc probabilities, we use them only for studying changes rel- ative to cosmological-constant models. Our main results are (1) the order of magnitude difference between the arc probabilities in low density, spatially flat and open CDM models found numerically is reproduced by our analytic model, and (2) dark-energy cosmologies with w> −1 increase the arc optical depth by at most a factor of two and are thus unlikely to reconcile arc statistics with spatially flat cosmological models with low matter density.
Thalamic projections to the hippocampal and entorhinal areas in the cat

The thalamic projections to the hippocampal formation and to the subicular and entorhinal areas in the cat have been studied with retrograde transport of horseradish peroxidase (HRP) or wheat germ agglutinin conjugated to HRP (WGA‐HRP) and anterograde transport of WGA‐HRP. Retrograde transport tracers injected in various parts of these cortices resulted in labeled cells in the midline, anterior, and lateral dorsal nuclei. Injections into the hippocampal formation or the subiculum led to retrograde labeling of cells in the reuniens nucleus of the ipsilateral thalamus throughout its rostrocaudal extent, whereas the restricted injections into the dentate gyrus and the inferior region of the hippocampus led to no labeling. Following an injection into the pre‐ and parasubiculum, a large number of labeled cells were seen not only in the reuniens nucleus but in other midline nuclei. In addition, a substantial number of labeled cells were also detected in the anterior and lateral dorsal nuclei, particularly in the anterodorsal nucleus, which contained densely arranged labeled cells throughout almost the entire rostrocaudal extent. An injection into the medial entorhinal area labeled a number of cells in the anterior nuclei and in the reuniens nucleus, particularly its dorsal part. Injections into various subdivisions of the lateral entorhinal area yielded different patterns of distribution of labeled cells in the thalamic nuclei. An injection into the ventromedial division (VMEA) led to abundant labeling of cells in the paraventricular and reuniens nuclei. After an injection into the ventral division (VLEA), numerous labeled cells were detected in the reuniens nucleus and a lesser number in the paraventricular nucleus at anterior levels. When an injection was made into the dorsal division (DLEA), a large number of labeled cells were detected in the reuniens nucleus, and less numerous labeled cells were found in the central medial nucleus. There appears to be a topographic arrangement of cortical projections of the reuniens nucleus. The pre‐ and parasubiculum receive projections from the most medial part of the reuniens nucleus near the midline, and the DLEA receives projections from the medial part of the nucleus. The cells projecting to the VLEA and MEA are distributed in the central part of the reuniens nucleus, and those to the VMEA are distributed in the lateral part. Anterograde experiments were also performed; injections of WGA‐HRP into the reuniens nucleus resulted in terminal labeling in the superficial layers of the subicular area and the neighboring hippocampus and in the entorhinal area.
Solving trigonometric moment problems for fast transient imaging

Transient images help to analyze light transport in scenes. Besides two spatial dimensions, they are resolved in time of flight. Cost-efficient approaches for their capture use amplitude modulated continuous wave lidar systems but typically take more than a minute of capture time. We propose new techniques for measurement and reconstruction of transient images, which drastically reduce this capture time. To this end, we pose the problem of reconstruction as a trigonometric moment problem. A vast body of mathematical literature provides powerful solutions to such problems. In particular, the maximum entropy spectral estimate and the Pisarenko estimate provide two closed-form solutions for reconstruction using continuous densities or sparse distributions, respectively. Both methods can separate m distinct returns using measurements at m modulation frequencies. For m = 3 our experiments with measured data confirm this. Our GPU-accelerated implementation can reconstruct more than 100000 frames of a transient image per second. Additionally, we propose modifications of the capture routine to achieve the required sinusoidal modulation without increasing the capture time. This allows us to capture up to 18.6 transient images per second, leading to transient video. An important byproduct is a method for removal of multipath interference in range imaging.
ANALYSIS OF PROGNOSTIC FACTORS IN PATIENTS WITH GASTRIC VARICES AFTER ENDOSCOPIC TREATMENT

Background: The prognostic factors, including gastric variceal bleeding itself, in patients with gastric varices (GV) after endoscopic treatment remain unclear. The aim of this study was to analyze prognostic factors in patients with GV after endoscopic treatment as well as to evaluate safety and efficacy of our endoscopic treatment.
Prevalence of Chagas Disease in Latin-American Migrants Living in Europe: A Systematic Review and Meta-analysis

Background Few studies have assessed the burden of Chagas disease in non-endemic countries and most of them are based on prevalence estimates from Latin American (LA) countries that likely differ from the prevalence in migrants living in Europe. The aim of this study was to systematically review the existing data informing current understanding of the prevalence of Chagas disease in LA migrants living in European countries. Methods We conducted a systematic review and meta-analysis of studies reporting prevalence of Chagas disease in European countries belonging to the European Union (EU) before 2004 in accordance with the MOOSE guidelines and based on the database sources MEDLINE and Global Health. No restrictions were placed on study date, study design or language of publication. The pooled prevalence was estimated using random effect models based on DerSimonian & Laird method. Results We identified 18 studies conducted in five European countries. The random effect pooled prevalence was 4.2% (95%CI:2.2-6.7%); and the heterogeneity of Chagas disease prevalence among studies was high (I2 = 97%,p<0.001). Migrants from Bolivia had the highest prevalence of Chagas disease (18.1%, 95%CI:13.9–22.7%). Conclusions Prevalence of Chagas in LA migrants living in Europe is high, particularly in migrants from Bolivia and Paraguay. Data are highly heterogeneous dependent upon country of origin and within studies of migrants from the same country of origin. Country-specific prevalence differs from the estimates available from LA countries. Our meta-analysis provides prevalence estimates of Chagas disease that should be used to estimate the burden of disease in European countries.
Versatile Stimulation Back-End With Programmable Exponential Current Pulse Shapes for a Retinal Visual Prosthesis.

This paper reports on the design, implementation, and test of a stimulation back-end, for an implantable retinal prosthesis. In addition to traditional rectangular pulse shapes, the circuit features biphasic stimulation pulses with both rising and falling exponential shapes, whose time constants are digitally programmable. A class-B second generation current conveyor is used as a wide-swing, high-output-resistance stimulation current driver, delivering stimulation current pulses of up to $\pm 96~\mu{\rm A}$ to the target tissue. Duration of the generated current pulses is programmable within the range of $100~\mu{\rm s}$ to 3 ms. Current-mode digital-to-analog converters (DACs) are used to program the amplitudes of the stimulation pulses. Fabricated using the IBM 130 nm process, the circuit consumes $1.5\times 1.5~{\rm mm}^{2}$ of silicon area. According to the measurements, the DACs exhibit DNL and INL of 0.23 LSB and 0.364 LSB, respectively. Experimental results indicate that the stimuli generator meets expected requirements when connected to electrode-tissue impedance of as high as 25 k $\Omega$ . Maximum power consumption of the proposed design is 3.4 mW when delivering biphasic rectangular pulses to the target load. A charge pump block is in charge of the upconversion of the standard 1.2-V supply voltage to $\pm 3.3{\rm V}$ .
Brassinosteroids: A Promising Option in Deciphering Remedial Strategies for Abiotic Stress Tolerance in Rice

Rice is an important staple crop as it feeds about a half of the earth’s population. It is known to be sensitive to a range of abiotic stresses which result in significant decline in crop productivity. Recently, the use of phytohormones for abiotic stress amelioration has generated considerable interest. Plants adapt to various environmental stresses by undergoing series of changes at physiological and molecular levels which are cooperatively modulated by various phytohormones. Brassinosteroids (BRs) are a class of naturally occurring steroidal phytohormones, best known for their role in plant growth and development. For the past two decades, greater emphasis on studies related to BRs biosynthesis, distribution and signaling has resulted in better understanding of BRs function. Recent advances in the use of contemporary genetic, biochemical and proteomic tools, with a vast array of accessible biological resources has led to an extensive exploration of the key regulatory components in BR signaling networks, thus making it one of the most well-studied hormonal pathways in plants. The present review highlights the advancements of knowledge in BR research and links it with its growing potential in abiotic stress management for important crop like rice.
How Do Tax Progressivity and Household Heterogeneity Affect Laffer Curves?

How much additional tax revenue can the government generate by increasing the level of labor income taxes? In this paper, we argue that the degree of tax progressivity is a quantitatively important determinant of the answer to this question. To make this point, we develop a large scale overlapping generations model with single and married households facing idiosyncratic income risk, extensive and intensive margins of labor supply, as well as endogenous accumulation of human capital through labor market experience. We calibrate the model to U.S. macro, micro, and tax data and characterize the labor income tax Laffer curve for various degrees of tax progressivity. We find that the peak of the U.S. Laffer curve is attained at an average labor income tax rate of 58 % . This peak (the maximal tax revenues the government can raise) increases by 7 % if the current progressive tax code is replaced with a flat labor income tax. Replacing the current U.S. tax system with one that has Denmark' s progressivity would lower the peak by 8 % . We show that modeling the extensive margin of labor supply and endogenous human capital accumulation is crucial for these findings. With joint taxation of married couples (as in the U.S.), higher tax progressivity leads to significantly lower labor force participation of married women and substantially higher labor force participation of single women, an effect that is especially pronounced when future wages of females depend positively on past labor market experience.
Breast Cancer by Age at Diagnosis in the Gharbiah, Egypt, Population-Based Registry Compared to the United States Surveillance, Epidemiology, and End Results Program, 2004–2008

Objective. Although breast cancers (BCs) in young women often display more aggressive features, younger women are generally not screened for early detection. It is important to understand the characteristics of young onset breast cancer to increase awareness in this population. This analysis includes all ages, with emphasis placed on younger onset BC in Egypt as compared to the United States. Methods. BC cases in the Gharbiah cancer registry (GCR), Egypt, were compared to those in the Surveillance, Epidemiology, and End Results (SEER) database. This analysis included 3,819 cases from the GCR and 273,019 from SEER diagnosed 2004–2008. Results. GCR cases were diagnosed at later stages, with <5% diagnosed at Stage I and 12% diagnosed at Stage IV. 48% of all SEER cases were diagnosed at Stage I, dropping to 30% among those ≤40. Significant differences in age, tumor grade, hormone receptor status, histology, and stage exist between GCR and SEER BCs. After adjustment, GCR cases were nearly 45 times more likely to be diagnosed at stage III and 16 times more likely to be diagnosed at stage IV than SEER cases. Conclusions. Future research should examine ways to increase literacy about early detection and prompt therapy in young cases.
Effects of pH on nitrite-induced formation of reactive nitrogen oxide species and their scavenging by phenolic antioxidants in human oral cavity

Nitrite-induced transformation of 3-amino-4-monomethylamino-2′,7′-difluorofluorecein (DAF-FM) to the triazol form (DAF-FMT) was studied using bacterial fraction of mixed whole saliva. The transformation at pH 7 was inhibited by SCN−, suggesting that nitrosative stresses were small in the oral cavity at the pH value as SCN− was a normal component of saliva. DAF-FMT formation was much faster at pH 5.2 than 7 and ONSCN generated by the reaction of HNO2 with SCN− mainly contributed to its formation at pH 5.2. Coffee and phenolic antioxidants inhibited the DAF-FMT formation less effectively at pH 5.2 than pH 7. The less effectiveness was discussed to be due to slow scavenging of ONSCN, which contributed mainly to the formation of DAF-FMT at pH 5.2, by coffee and phenolics. Since nitrite-induced formation of ONSCN should become faster as the pH decreases, it was suggested that nitrosative stresses to oral tissues became serious under acidic conditions.
Thrombocytosis in the Setting of Isomerism and a Functionally Univentricular Heart

Introduction Bodily isomerism, also known as heterotaxy, is a unique entity in which there is mirror imagery in various organ systems. Those with isomerism will often have congenital malformations of the heart requiring functionally univentricular palliation. Anecdotally, thrombocytosis has been noted with higher frequency in patients with isomerism. This study aimed to determine the prevalence of thrombocytosis at different stages and identify independent predictors of thrombocytosis. Methods We identified patients with isomerism and a functionally univentricular heart who received care at our institution between January 1998 and January 2014. Clinical data regarding these patients was collected via chart review. Platelet counts were collected before initial surgical palliation, the day prior to second surgical palliation, and the day prior to the third surgical palliation. Platelet counts from the first postoperative day following all three surgical palliations was also collected. Mean platelet counts were compared between consecutive stages as well as to the initial platelet count. The frequency of thrombocytosis was also calculated at each point with a binomial logistic regression conducted to determine independent risk factors of thrombocytosis at each time point. Results A total of 57 patients were included in the analysis. The mean platelet count before initial surgical palliation was 349.21 x 109/L and decreased with age. Thrombocytosis was noted in 15.8% prior to initial surgical palliation and 23.6% prior to second surgical palliation. Thrombocytosis was no longer noted after second surgical palliation. No independent risk factors for thrombocytosis were identified. Conclusion Thrombocytosis is not infrequent during the first year of life in those with isomerism. It is important to be vigilant of platelet counts in this population as thrombocytosis may lead to increased thromboembolic events, particularly in the setting of a Blalock-Taussig shunt. Thrombocytosis nearly always resolves after the second surgical palliation.
Acceleration of Wound Healing Process Using Lactoferrin by Stimulating Proliferation of Fibroblasts in Wistar Rats (Rattus Novergicus): In Vivo Method

Wound is disruptions in the uniformity of body tissue structure, including the outermost layer from the skin to the internal organs, parts of fat, muscles, bones, and others. To address this issue, lactoferrin is a bioactive compound with promising benefits, playing a crucial role in wound healing by enhancing fibroblasts migration and proliferation, as well as collagen synthesis. Moreover, when used in wound therapy, lactoferrin induces a decrease in pro-inflammatory cytokines production by macrophages with an increase in the expression of VEGF and FGF-2. This study aimed to determine the role of lactoferrin in accelerating in vivo incision wound healing in Wistar rats and to prove the correlation between fibroblasts and collagen. This study adopted a laboratory experimental design using a post-test only control group with 28 samples. The samples were divided into the control, and three experimental groups, each treated with two drops of Lactoferrin (Shaner Whey Protein) at 20 mg/ml, 40 mg/ml, and 80 mg/ml. Each sample was observed for an increase in fibroblasts proliferation and density of collagen fibers. Lactoferrin concentration of 80 mg/ml had the most effect on increasing the number of fibroblasts and collagen with a significant value > 0.05, using a posthoc test. Lactoferrin concentration of 80mg/ml showed the most significant results, showing a significant acceleration in wound healing process.