Miracle-dz/UniFAR-FTUs huggingface dataset:
Different Representations of Potential and Selected Motor Plans by Distinct Parietal Areas

Traditional theories have considered decision making as a separate neural process occurring before action planning. However, recent neurophysiological studies of spatial target selection have suggested that decision making and motor planning may be performed in an integrated manner. It was proposed that multiple potential plans are concurrently formed and the ultimately selected action simultaneously emerges within the same circuits (Shadlen and Newsome, 2001; Cisek and Kalaska, 2010). In the present study, we recorded from the parietal reach region (PRR) and dorsal area 5 (area 5d) in the posterior parietal cortex (PPC) while monkeys performed a nonspatial effector (saccade vs reach) choice task. The results show that PRR encodes potential and selected reach plans whereas area 5d encodes only selected reach plans, suggesting a serial visuomotor cortical circuitry for nonspatial effector decisions. Thus, there appears to be a different flow of processing for decisions and planning for spatial target selection, which is more integrated, and nonspatial effector decisions between eye and limb movements, which are more serial.
Job satisfaction of sport and physical activity instructors in Spain according to gender and age

The purpose of this study was to assess the extent to which sport and physical activity instructors are satisfied with their working conditions and performance, and how levels of job satisfaction varied across different genders and ages of sport and physical activity instructors. Sport and physical activity instructors (N=600) (ultimately N=545; males=356, females=189), from Spain formed the target group for the survey. Key results indicate that sport and physical activity instructors experienced job satisfaction due to their relationship with their colleagues, the feeling that their occupation was valued by their peers, the job itself, the level of autonomy and the level of their performance. However, they experienced dissatisfaction with the lack of training and promotional opportunities, the financial remuneration, the environmental conditions and lack of personal safety. A major finding was that sport and physical activity instructors who experienced higher levels of job satisfaction were males aged 45 years or older. Despite the fact that the results revealed that sport and physical activity instructors were generally satisfied with their jobs, further research needs to examine ways to increase job satisfaction by reducing negative elements.
NBS1 Heterozygosity and Cancer Risk

Biallelic mutations in the NBS1 gene are responsible for the Nijmegen breakage syndrome (NBS), a rare autosomal recessive disorder characterized by chromosome instability and hypersensitivity to ionising radiation (IR). Epidemiological data evidence that the NBS1 gene can be considered a susceptibility factor for cancer development, as demonstrated by the fact that almost 40% of NBS patients have developed a malignancy before the age of 21. Interestingly, also NBS1 heterozygotes, which are clinically asymptomatic, display an elevated risk to develop some types of malignant tumours, especially breast, prostate and colorectal cancers, lymphoblastic leukaemia, and non-Hodgkin’s lymphoma (NHL). So far, nine mutations in the NBS1 gene have been found, at the heterozygous state, in cancer patients. Among them, the 657del5, the I171V and the R215W mutations are the most frequently described. The pathogenicity of these mutations is presumably connected with their occurrence in the highly conserved BRCT tandem domains of the NBS1 protein, which are present in a large superfamily of proteins, and are recognized as major mediators of processes related to cell-cycle checkpoint and DNA repair. This review will focus on the current state-of-knowledge regarding the correlation between carriers of NBS1 gene mutations and the proneness to the development of malignant tumours.
Ultraluminous X-Ray Sources in External Galaxies

We investigate models for the class of ultraluminous nonnuclear X-ray sources (i.e., ultraluminous compact X-ray sources [ULXs]) seen in a number of galaxies and probably associated with star-forming regions. Models in which the X-ray emission is assumed to be isotropic run into several difficulties. In particular, the formation of sufficient numbers of the required ultramassive black hole X-ray binaries is problematic, and the likely transient behavior of the resulting systems is not in good accord with observation. The assumption of mild X-ray beaming suggests instead that ULXs may represent a short-lived but extremely common stage in the evolution of a wide class of X-ray binaries. The best candidate for this is the phase of thermal-timescale mass transfer that is inevitable in many intermediate- and high-mass X-ray binaries. This in turn suggests a link with the Galactic microquasars. The short lifetimes of high-mass X-ray binaries would explain the association of ULXs with episodes of star formation. These considerations still allow the possibility that individual ULXs may contain extremely massive black holes.
Syndrome of Inappropriate Anti-Diuretic Hormone Secondary to Non-Cirrhotic Primary Hepatocellular Carcinoma

Patient: Male, 71 Final Diagnosis: SIADH Symptoms: Cachexia • confusion Medication: — Clinical Procedure: Percutaneous liver biopsy Specialty: Oncology Objective: Rare disease Background: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is usually seen in pulmonary malignancies, central nervous system disorders, and secondary to medications. SIADH has very rarely been encountered in primary hepatocellular carcinoma. Two cases were reported in Japan and 1 case in Spain after extensive investigation of the medical records. Case Report: We report a case of a 71-year-old man who presented with confusion, cachexia, and abdominal symptoms in the form of vomiting and abdominal discomfort. On the initial work-up, SIADH diagnosis was made. After an extensive work-up, the reason for SIADH turned out to be a newly diagnosed hepatocellular carcinoma. The precipitating factor for the cancer was not identified by history or by work-up. No metastasis was identified. Liver functions were preserved but patient was severely malnourished. Conclusions: SIADH can occur as a para-malignant feature of the malignancy. In our case, it was related to the hepatocellular carcinoma, which is a malignancy very rare to cause SIADH.
The appearance of accountability: communication technologies and power asymmetries in humanitarian aid and disaster recovery

New communication technologies are celebrated for their potential to improve the accountability of humanitarian agencies. The response to Typhoon Haiyan in 2013 represents the most systematic implementation of ‘accountability to affected people’ initiatives. Drawing on a year-long ethnography of the Haiyan recovery and 139 interviews with humanitarian workers and affected people, the article reveals a narrow interpretation of accountability as feedback which is increasingly captured through mobile phones. We observe that the digitized collection of feedback is not fed back to disaster-affected communities, but is directed to donors as evidence of ‘impact’. Rather than improving accountability to affected people, digitized feedback mechanisms sustained humanitarianism’s power asymmetries.
Efficacy and safety of rivaroxaban compared with warfarin in patients with peripheral artery disease and non-valvular atrial fibrillation: insights from ROCKET AF.

AIMS Vascular disease is included in a risk scoring system to predict stroke in patients with non-valvular atrial fibrillation (AF). This post hoc analysis of ROCKET AF aimed to determine the absolute rates of stroke and bleeding, and the relative effectiveness and safety of rivaroxaban vs. warfarin in patients with and without peripheral artery disease (PAD). Peripheral artery disease was defined on the case-report form as the presences of intermittent claudication, amputation for arterial insufficiency, vascular reconstruction, bypass surgery, or percutaneous intervention to the extremities, or previously documented abdominal aortic aneurysm. METHODS AND RESULTS ROCKET AF was a double-blind, double-dummy, randomized-controlled trial comparing rivaroxaban and warfarin for the prevention of stroke or systemic embolism. A total of 839 (5.9%) patients in ROCKET AF had PAD. Patients with and without PAD had similar rates of stroke or systemic embolism [HR: 1.04, 95% CI (0.72, 1.50), P = 0.84] and major or non-major clinically relevant (NMCR) bleeding [HR: 1.11, 95% CI (0.96, 1.28), P = 0.17], respectively. The efficacy of rivaroxaban when compared with warfarin for the prevention of stroke or systemic embolism was similar in patients with PAD (HR: 1.19, 95% CI: 0.63-2.22) and without PAD (HR: 0.86, 95% CI: 0.73-1.02; interaction P = 0.34). There was a significant interaction for major or NMCR bleeding in patients with PAD treated with rivaroxaban compared with warfarin (HR: 1.40, 95% CI: 1.06-1.86) compared with those without PAD (HR: 1.03, 95% CI: 0.95-1.11; interaction P = 0.037). CONCLUSION Patients with PAD in ROCKET AF did not have a statistically significant higher risk of stroke or systemic embolism than patients without PAD, and there were similar efficacy outcomes in patients treated with rivaroxaban and warfarin. In PAD patients, there was a higher risk of major bleeding or NMCR bleeding with rivaroxaban when compared with warfarin (interaction P = 0.037). Further investigation is warranted to validate this subgroup analysis and determine the optimal treatment in this high-risk cohort of AF patients with PAD.
Primary Human Meningiomas Regulation of DNA Synthesis and Growth of Cells Derived from Updated

\Vc have studied the effects of insulin, epidermal growth factor (EGF), fibroblast growth factor (FGF), platelet-derived growth factor, and steroid hormones (estradiol, progesterone, and cortisol) on human meningioma cell proliferation and DNA synthesis in a serum-free culture system. The growth factors, particularly EGF and FGF, increased DNA synthesis in a dose-dependent manner as measured by |3H)thymidine incorporation, and they stimulated submaximal cell proliferation. No individual factor or combination of factors was able to successfully reproduce the effects of 10% fetal calf serum (FCS) on cell growth, although a combination of platelet-derived growth factor (5 units/ml) and EGF (10 ng/ml) synergistically stimulated DNA synthesis to near maximal levels. In addition, serum dependency was observed in studies involving the mitogenic effects of insulin, EGF, or FGF. Both EGF and FGF (10 ng/ml) maximally stimulated cell growth in the presence of 5% FCS. The effects of steroid hormones on cell proliferation, individually or in combination with growth factors or charcoal-treated FCS, were also evaluated. Estradiol (100 n\D significantly increased cell number over control values only in the presence of charcoal-treated FCS; no effects of progesterone or cortisol on cell proliferation were observed. In conclusion, both EGF and FGF stimulated cell proliferation and DNA synthesis in human meningioma cultures in a serum-free system, whereas steroid hormones were without effect. It appears that additional serum components are required for both estradiol-stimulated growth and for maximal proliferation of human meningioma cells under serum-free
Improving the Academic Performance of Non-Native English-Speaking Students: The Contribution of Pre-Sessional English Language Programmes.

There is an established, if weak, inverse relationship between levels of English language proficiency and academic performance in higher education. In response, higher education institutions (HEIs) insist upon minimum entry requirements concerning language for international applicants. Many HEIs now also offer pre-sessional English courses to bring applicants up to the designated language requirement. This paper revisits the research into language proficiency and academic performance using data on all full-time students (17,925) attending a major UK HEI in the academic year 2011–2012, 4,342 of whom were non-native English speakers. The findings confirm that while higher International English Language Testing System (IELTS) marks at entry translate into higher grade point averages (GPAs), students who undertake pre-sessional courses do notably worse in GPA terms than students who arrive with acceptable (for the course) IELTS scores. These findings suggest HEIs (and, by extension, international students) could benefit from a review regarding the appropriateness of current pre-sessional English language proficiency programmes.
The challenges to discussing emotionally loaded stories in Finnish teacher education

Abstract It has been increasingly acknowledged that emotions are a significant dimension in teachers’ work and professional development, and an inseparable part of reflection promoted in the research-based teacher education. However, at the same time the difficulty of prompting student-teachers to reflect on their emotions in teacher education has been recognised. This article focuses on this difficulty by examining how emotionally loaded stories about teachers’ work were dealt with by soon-to-graduate Finnish student-teachers attending peer group mentoring sessions. We illustrate this group-level phenomenon (the challenge of discussing emotionally loaded stories) through the examples provided by one of the participants, Hannele (pseudonym). Our results revealed that emotionally loaded stories in this peer group were often responded to with laughter and humour or via masking or silencing. Participants seemed to avoid deeper emotional reflection on uncertainty related to oneself and to the teaching profession, therefore maintaining an image of a proper (student) teacher. Our results have implications for both peer group mentoring and pre-service teacher education.
Effect of Sucrose Concentration on Sucrose-Dependent Adhesion and Glucosyltransferase Expression of S. mutans in Children with Severe Early-Childhood Caries (S-ECC)

Sucrose, extracellular polysaccharide, and glucosyltransferases (GTFs) are key factors in sucrose-dependent adhesion and play important roles in the process of severe early-childhood caries (S-ECC). However, whether sucrose concentration regulates gtf expression, extracellular polysaccharide synthesis, and sucrose-dependent adhesion is related to the different genotypes of S. mutans isolated from ECC in children and still needs to be investigated. In this study, 52 strains of S. mutans were isolated from children with S-ECC and caries-free (CF) children. Water-insoluble glucan (WIG) synthesis was detected by the anthrone method, adhesion capacity by the turbidimetric method, and expression of gtf by RT-PCR in an in vitro model containing 1%–20% sucrose. The genotypes of S. mutans were analyzed by AP-PCR. The results showed that WIG synthesis, adhesion capacity, and gtf expression increased significantly when the sucrose concentration was from 1% to 10%. WIG synthesis and gtfB as well as gtfC expression of the 1% and 5% groups were significantly lower than those of the 10% and 20% groups (p < 0.05). There were no significant differences between the 10% and 20% groups. The fingerprints of S. mutans detected from individuals in the S-ECC group exhibited a significant difference in diversity compared with those from CF individuals (p < 0.05). Further, the expression of gtfB and gtfC in the S-ECC group was significantly different among the 1- to 5-genotype groups (p < 0.05). It can be concluded that sucrose-dependent adhesion might be related to the diversity of genotypes of S. mutans, and the 10% sucrose level can be seen as a “turning point” and essential factor for the prevention of S-ECC.
Intention = Choice + Commitment

This paper provides a logical analysis of the concept of intention as composed of two more basic concepts, choice (or goal) and commitment. By making explicit the conditions under which an agent can drop her goals, i.e., by specifying how the agent is committed to her goals, the formalism provides analyses for Bratman's three characteristic functional roles played by intentions [Bratman, 1986], and shows how agents can avoid intending all the foreseen side-effects of what they actually intend. Finally, the analysis shows how intentions can be adopted relative to a background of relevant beliefs and other intentions or goals. By relativizing one agent's intentions in terms of beliefs about another agent's intentions (or beliefs), we derive a preliminary account of interpersonal commitments.
A Conceptual Model of Unified Theory of Acceptance and Use of Technology (UTAUT) Modification with Management Effectiveness and Program Effectiveness in Context of Telecentre

Limited access to telecommunication infrastructures has left communities in remote and rural areas in most of the developing countries at disadvantage positions in t erms of accessibility to ICTs. Telecentre projects are implemented in an attempt to curtail this anomaly by providing IT fac ilities in shared manner. This paper attempts to pu t forward a conceptual Model of UTAUT Modification with Management effectiveness and Program effectiveness constructs towards user acceptance of Telecentre. The paper's approach is base on literat ure review on the basis that, the incorporation of these constructs into UTAUT model in context of Telecentre demand attention. Th e constructs are proposed as antecedent factors of user acceptance of this useful tool of bridging digital divide. Consequentl y, the proposed model is set forward as the basis f or future empirical study in this area.
Opportunities and Challenges in Crowdsourced Wardriving

Knowing the physical location of a mobile device is crucial for a number of context-aware applications. This information is usually obtained using the Global Positioning System (GPS), or by calculating the position based on proximity of WiFi access points with known location (where the position of the access points is stored in a database at a central server). To date, most of the research regarding the creation of such a database has investigated datasets collected both artificially and over short periods of time (e.g., during a one-day drive around a city). In contrast, most in-use databases are collected by mobile devices automatically, and are maintained by large mobile OS providers. As a result, the research community has a poor understanding of the challenges in creating and using large-scale WiFi localization databases. We address this situation using the deployment of over 800 mobile devices to real users over a 1.5 year period. Each device periodically records WiFi scans and its GPS coordinates, reporting the collected data to us. We identify a number of challenges in using such data to build a WiFi localization database (e.g., mobility of access points), and introduce techniques to mitigate them. We also explore the level of coverage needed to accurately estimate a user's location, showing that only a small subset of the database is needed to achieve high accuracy.
Automatically recommending code reviewers based on their expertise: An empirical comparison

Code reviews are an essential part of quality assurance in Free, Libre, and Open Source Software (FLOSS) projects. However, finding a suitable reviewer can be difficult, and delayed or forgotten reviews are the consequence. Automating reviewer selection with suitable algorithms can mitigate this problem. We compare empirically six algorithms based on modification expertise and two algorithms based on review expertise on four major FLOSS projects. Our results indicate that the algorithms based on review expertise yield better recommendations than those based on modification expertise. The algorithm Weighted Review Count (WRC) recommends at least one out of five reviewers correctly in 69 % to 75 % of all cases, which is one of the best results achieved in the comparison.
LIKELIHOOD ANALYSIS OF ONGOING GENE FLOW AND HISTORICAL ASSOCIATION

Abstract We develop a Monte Carlo–based likelihood method for estimating migration rates and population divergence times from data at unlinked loci at which mutation rates are sufficiently low that, in the recent past, the effects of mutation can be ignored. The method is applicable to restriction fragment length polymorphisms (RFLPs) and single nucleotide polymorphisms (SNPs) sampled from a subdivided population. The method produces joint maximum-likelihood estimates of the migration rate and the time of population divergence, both scaled by population size, and provides a framework in which to test either for no ongoing gene flow or for population divergence in the distant past. We show the method performs well and provides reasonably accurate estimates of parameters even when the assumptions under which those estimates are obtained are not completely satisfied. Furthermore, we show that, provided that the number of polymorphic loci is sufficiently large, there is some power to distinguish between ongoing gene flow and historical association as causes of genetic similarity between pairs of populations. Corresponding Editor: E. Zouros
New daters’ acute physiological responses to a standardized stressor : do nonadaptive hormone responses forecast romantic breakups?

The quality and longevity of any romantic relationship depends in large part on the manner in which individuals respond to stressful situations (Karney & Bradbury, 1995). Research on the link between stress and relationship outcomes has focused almost exclusively on marital relationships. With this in mind, the current study explored associations between general stress responses (i.e., reactivity and recovery) to a psychosocial stressor and nonmarital breakup status. Data were collected as part of a larger 9-month longitudinal study investigating the mental and physical health outcomes associated with relationship transitions (e.g., breakups). Participants underwent a standardized stress protocol (i.e., The Trier Social Stress Test; Kirschbaum, Pirke, & Hellhammer, 1993) that incorporates motivated performance tasks, uncontrollability, and social-evaluative threat—all of which are key components to reliably eliciting a stress response (Dickerson & Kemeny, 2004). Physiological reactivity and recovery were assessed using samples of salivary cortisol, a stress hormone of the hypothalamic-pituitary-adrenal (HPA) axis—one of the body’s primary stress response systems. Results from multilevel modeling indicated that cortisol trajectories among those whose relationships persisted versus those whose relationships ended were not significantly different from one another. Additionally, individuals who displayed nonadaptive hormone responses to a novel setting and a standardized stressor (i.e., took longer to recover, demonstrated greater increases in total cortisol output) were no more likely to report experiencing a breakup than were individuals who displayed adaptive responses to the same settings. Findings are discussed with regard to identifying factors that may be related to patterns of physiological function and nonmarital relationship outcomes.