Miracle-dz/UniFAR-FTUs huggingface dataset:
Direct Modification and Activation of a Nuclear Receptor–PIP2 Complex by the Inositol Lipid Kinase IPMK

The transcriptional activity of a nuclear receptor is regulated by the phosphorylation status of a bound lipid. Targeting the Lipid Ligand to Regulate Transcription Steroidogenic factor 1 (SF-1) is a nuclear receptor that transcriptionally activates genes involved in sexual development and reproduction. Blind et al. found that phosphatidylinositol 4,5-bisphosphate (PIP2) bound to SF-1 was phosphorylated by inositol polyphosphate multikinase (IPMK) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). Conversely, the lipid phosphatase PTEN dephosphorylated the SF-1–PIP3 complex. The transcriptional activity of SF-1 was decreased in cells after inhibiting IPMK and increased in cells overexpressing PTEN. Thus, phosphorylation of its associated lipid, rather than the nuclear receptor itself, activates SF-1 and identifies another signaling role for nuclear phosphoinositides. Phosphatidylinositol 4,5-bisphosphate (PIP2) is best known as a plasma membrane–bound regulatory lipid. Although PIP2 and phosphoinositide-modifying enzymes coexist in the nucleus, their nuclear roles remain unclear. We showed that inositol polyphosphate multikinase (IPMK), which functions both as an inositol kinase and as a phosphoinositide 3-kinase (PI3K), interacts with the nuclear receptor steroidogenic factor 1 (SF-1) and phosphorylates its bound ligand, PIP2. In vitro studies showed that PIP2 was not phosphorylated by IPMK if PIP2 was displaced or blocked from binding to the large hydrophobic pocket of SF-1 and that the ability to phosphorylate PIP2 bound to SF-1 was specific to IPMK and did not occur with type 1 p110 PI3Ks. IPMK-generated SF-1–PIP3 (phosphatidylinositol 3,4,5-trisphosphate) was dephosphorylated by the lipid phosphatase PTEN. Consistent with the in vitro activities of IPMK and PTEN on SF-1–PIPn, SF-1 transcriptional activity was reduced by silencing IPMK or overexpressing PTEN. This ability of lipid kinases and phosphatases to directly remodel and alter the activity of a non–membrane protein–lipid complex establishes a previously unappreciated pathway for promoting lipid-mediated signaling in the nucleus.
Percutaneous coronary intervention in the elderly with ST-segment elevation myocardial infarction

As a result of increased life expectancy, octogenarians constitute an increasing proportion of patients admitted to hospital for ST-segment elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention is currently the treatment of choice for octogenarians presenting with STEMI. The recent literature on this topic has yielded controversial results, even though advances in drug-eluting stents and new types of antithrombotic agents are improving the management of STEMI and postoperative care. In this paper, we review the current status of percutaneous coronary intervention in the elderly with STEMI, including the reasons for their high mortality and morbidity, predictors of mortality, and strategies to improve outcomes.
Fast optimization of large antenna arrays on dielectric layers using surrogate Macro-Basis-Function representations

A fast full-wave simulation for the synthesis of printed antenna arrays is presented. The technique relies on a fast simulation scheme, exploiting the Macro Basis Functions (MBF) technique, to quickly analyze arrays. Mutual coupling (MC) is taken into account by exploiting the embedded element patterns in the synthesis process. The technique is hybridized with an iterative convex optimization to effectively optimize antenna excitation and locations in a double-step optimization routine. The synthesized arrays will therefore fulfill all requirements. The performance of the method is validated for arrays of printed bowtie antennas.
Automated analysis of eclipsing binary light curves – II. Statistical analysis of OGLE LMC eclipsing binaries

In the first paper of this series, we presented EBAS – Eclipsing Binary Automated Solver, a new fully automated algorithm to analyse the light curves of eclipsing binaries, based on the EBOP code. Here, we apply the new algorithm to the whole sample of 2580 binaries found in the Optical Gravitational Lensing Experiment (OGLE) Large Magellanic Cloud (LMC) photometric survey and derive the orbital elements for 1931 systems. To obtain the statistical properties of the short-period binaries of the LMC, we construct a well-defined subsample of 938 eclipsing binaries with main-sequence B-type primaries. Correcting for observational selection effects, we derive the distributions of the fractional radii of the two components and their sum, the brightness ratios and the periods of the short-period binaries. Somewhat surprisingly, the results are consistent with a flat distribution in log P between 2 and 10 d. We also estimate the total number of binaries in the LMC with the same characteristics, and not only the eclipsing binaries, to be about 5000. This figure leads us to suggest that (0.7 ± 0.4) per cent of the main-sequence B-type stars in the LMC are found in binaries with periods shorter than 10 d. This frequency is substantially smaller than the fraction of binaries found by small Galactic radial-velocity surveys of B stars. On the other hand, the binary frequency found by Hubble Space Telescope (HST) photometric searches within the late main-sequence stars of 47 Tuc is only slightly higher and still consistent with the frequency we deduced for the B stars in the LMC.
Non-conformal examples of AdS-CFT

Asymptotically anti-de Sitter spacetimes with Poincareinvariance along the boundary can describe, via the AdS-CFT correspondence, either relevant deformations of a conformal field theory or non-conformal vacuum states. I consider examples of both types constructed within the framework of five-dimensional gauged supergravity. I explain the proof and motivation of a gravitational `c -theorem' which is independent of dimension. I show how one class of examples can be elevated to ten-dimensional geometries involving distributions of parallel D3-branes. For these cases some peculiar properties of two-point functions emerge, and I close with speculations on their physical origin.
Sport Psychology - Past, Present and Future: The Perceptions of Swedish Sport Psychology Students

Interest in sport psychology has accelerated in the last 15-20 years, partly due to the increased realization that the winning edge in many sports is not just physical superiority, but rather a combination of psychological, physiological and technical factors. Health oriented issues such as the importance of physical activity in relation to well being and quality of life (Buckworth & Dishman, 2002) and applied issues such as the development of professional philosophy as a basis for successful sport psychology delivery (Poczwardowski, Sherman & Ravizza, 2004) have also contributed to the rising interest in the field. In order to describe the current and future developments in sport psychology, Swedish students answered questions administered by the author.
Detection of Y chromosome material in a 46,XX male with SRY translocation: novel application of cell‐free fetal DNA testing

The patient was a 41-year-old Caucasian primigravida who was referred at 18weeks of gestation for elevated risk of trisomy 21 (1:56) on sequential integrated serum screen. She also had cell-free fetal DNA (cffDNA) screening in the first trimester indicating normal representation of chromosomes 13, 18, and 21 and presence of Y chromosome material, consistent with a male fetus. Patient’s medical and family history were noncontributory. The pregnancy was conceived via intrauterine insemination secondary to male factor infertility in her 43year-old partner. The partner’s family history includes a nephew with autism. The partner had declined peripheral karyotyping during the initial infertility work-up. The patient had previously had a universal carrier screen (Counsyl) which identified no mutations in any of the genes tested. After detailed genetic counseling regarding the discordant aneuploidy screening results between sequential integrated screen and cffDNA, the patient elected to proceed with detailed anatomical survey and diagnostic amniocentesis. On the ultrasound, a phenotypic male fetus with an isolated echogenic intracardiac focus was seen. Results of the amniocentesis revealed 46,XX (normal female, with 15 cells counted), which now created a second discrepant result between the visualized anatomy on ultrasound and prior cffDNA testing. A follow-up ultrasound was performed to reassess fetal anatomy following the results of the amniocentesis, which again confirmed non-ambiguous male genitalia in the fetus. The patient’s testing results are summarized in Table 1. Sample mix-up and mislabeling were excluded on internal quality control from both the maternal–fetal medicine office and laboratory. An analysis of 15 additional cell colonies confirmed 46,XX karyotype in all cells analyzed. A fluorescence in situ hybridization probe for the SRY gene and X chromosome centromeric control probe DXZ1 were used to analyze ten metaphase cells. Results indicated that the SRY region was present on the distal short arm of one of the X chromosomes [46,XX.ishder(X)t(X;Y)(p22.3;p11.3)(SRY+,DXZ1+)]. The couple declined parental peripheral blood chromosome analysis with SRY analysis. Additional fetal microarray analysis was also offered and declined.
Security Operations Centers for Information Security Incident Management

At present information security (IS) incidents have become not only more numerous and diverse but also more damaging and disruptive. Preventive controls based on the IS risk assessment results decrease the majority but not all the IS incidents. Therefore, an IS incident management system is necessary for rapidly detecting IS incidents, minimizing loss and destruction, mitigating the vulnerabilities that were exploited and restoring the Internet of Things infrastructure (IoTI), including its IT services. These systems can be implemented on the basis of a Security Operations Center (SOC). Based on the related works a survey of the existing SOCs, their mission and main functions is given. The SOCs' classification as well as the key indicators of IS incidents in IoTI are proposed. Some serious first-generation SOCs' limitations are defined. This analysis leads to the main area of further research launched by the author.
Differential and coherent decorrelating multiuser receivers for space-time-coded CDMA systems

Previously, we proposed a differential space-code modulation (DSCM) scheme that integrates the strength of differential space-time coding and spreading to achieve interference suppression and resistance to time-varying channel fading in single-user environments. In this paper, we consider the problem of multiuser receiver design for code-division multiple-access (CDMA) systems that utilize DSCM for transmission. In particular, we propose two differential receivers for such systems. These differential receivers do not require the channel state information (CSI) for detection and, still, are resistant to multiuser interference (MUI) and time-varying channel fading. We also propose a coherent receiver that requires only the CSI of the desired user for detection. The coherent receiver yields improved performance over the differential receivers when reliable channel estimates are available (e.g., in slowly fading channels). The proposed differential/coherent receivers are decorrelative schemes that decouple the detection of different users. Both long and short spreading codes can be employed in these schemes. Numerical examples are presented to demonstrate the effectiveness of the proposed receivers.
Service discovery and access in vehicle-to-roadside multi-channel VANETs

A wide portfolio of safety and non-safety services will be provided to drivers and passengers on top of Vehicular Ad Hoc Networks (VANETs). Non-safety services are announced by providers, e.g., road-side units (RSUs), on a channel that is different from the one where the services are delivered. The dependable and timely delivery of the advertisement messages is crucial for vehicles to promptly discover and access the announced services in challenging vehicle-to-roadside scenarios, characterized by intermittent and shortlived connectivity. In this paper, we present an analytical framework that models the service advertisement and access mechanisms in multichannel vehicular networks. The model accounts for dual-radio devices, and computes the mean service discovery time and the service channel utilization by considering the disruption periods due to the switching of the RSU from the advertising channel (where announcements are transmitted) to the advertised channel (where services are exchanged), under different channel and mobility conditions. It provides quick insights on parameter settings to allow providers to improve service provisioning.
Crack-seal patterns: records of uncorrelated stress release variations in crustal rocks

Abstract Statistical properties of crack-seal veins are investigated with a view to assessing stress release fluctuations in crustal rocks. Crack-seal patterns correspond to sets of successive parallel fractures that are assumed to have propagated by a subcritical crack mechanism in the presence of a reactive fluid. They represent a time-sequence record of an aseismic and anelastic process of rock deformation. The statistical characteristics of several crack-seal patterns containing several hundreds of successive cracks have been studied. Samples were collected in three different areas, gold-bearing quartz veins from Abitibi in Canada, serpentine veins from the San Andreas system in California and calcite veins from the Apennine Mountains in Italy. Digitized pictures acquired from thin sections allow accurate measurement of crack-seal growth increments. All the samples show the same statistical behaviour regardless of their geological origin. The crack-seal statistical properties are described by an exponential distribution with a characteristic length scale and do not show any spatial correlation. They differ from other fracture patterns, such as earthquake data, which exhibit power-law correlations (Gutenberg-Richter relationship). Crack-seal series represent a natural fossil record of stress release variations (less than 50 bars) in the crust that show a characteristic length scale, associated with the resistance of rock to effective tension, and no correlation in time.
An improved hybrid genetic algorithm for the generalized assignment problem

We consider the generalized assignment problem in which the objective is to find a minimum cost assignment of a set of jobs to a set of agents subject to resource constraints. The presented new approach is based on a previously published, successful hybrid genetic algorithm and includes as new features two alternative initialization heuristics, a modified selection and replacement scheme for handling infeasible solutions more appropriately, and a heuristic mutation operator. Tests are performed on standard test instances from the literature and on newly created, larger and more difficult instances. The presented genetic algorithm with its two initialization variants is compared to the previous genetic algorithm and to the commercial general purpose branch-and-cut system CPLEX. Results indicate that CPLEX is able to solve relatively large instances of the general assignment problem to provable optimality. For the largest and most difficult instances, however, the proposed genetic algorithm yields on average the best results in shortest time.
Trust dynamics: how trust is influenced by direct experiences and by trust itself

In this paper we will examine two main aspects of trust dynamics: a) How direct experiences involving trust, with their successes or failures, influence the future trust of an agent about similar facts. We challenge the trivial idea that always success increases trust while failure decreases it. Of course, this primitive view cannot be avoided till Trust is modeled just as a simple index, a dimension, a number; for example reduced to mere subjective probability. We claim that a cognitive attribution process is needed in order to update trust on the basis of an 'interpretation' of the outcome of A's reliance on B and of B's performance (failure or success). b) How the fact that A trusts B and relies on it in situation Ω can actually (objectively) influence B's trustworthiness in the /Spl Omega/ situation. Either trust is a selffulfilling prophecy that modifies the subjective probability of the predicted event; or it is a self-defeating strategy by negatively influencing the events. These phenomena are very crucial in human societies (states, market, groups), but also in computer mediated Organizations, Interactions (EC), Cooperation (CSCW) and even in Multi-Agent Systems with autonomous agents. We present a formal model of these dynamic nontrivial aspects.
Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis.

OBJECTIVES To examine the relationship between patient-reported depression and adherence to therapy with interferon beta-1b (IFN beta-1b) and to test the hypothesis that treatment of depression is associated with improved adherence. DESIGN Patients with multiple sclerosis were followed up 6 months after initiating therapy with IFN beta-1b. SETTING A university outpatient multiple sclerosis center, an academic group practice, and a health maintenance organization. PATIENTS Eighty-five patients with clinically evident multiple sclerosis taking IFN beta-1b. MAIN OUTCOME MEASURE Follow-up questionnaire. RESULTS Thirty-five (41%) of the 85 patients reported new or increased depression within 6 months of initiating therapy with IFN beta-1b. Patients experiencing symptoms of depression were more likely to discontinue therapy. Among the patients reporting new or increased depression, 86% who received psychotherapy or antidepressant medication and 38% of the patients who received no therapy for depression continued the IFN beta-1b therapy (P = .003). Although psychotherapy was used as a treatment option more frequently in university and academic group practice-based multiple sclerosis clinics than in the health maintenance organization (P = .02), the treatment adherence patterns were similar across sites. CONCLUSIONS These findings support previous findings that patients report increased depression after initiating therapy with IFN beta-1b. Although the source of this depression is unclear, these findings suggest that treating patient-reported depression increases adherence to treatment.
Differential Neural Responses during Performance of Matching and Nonmatching to Sample Tasks at Two Delay Intervals

Visual short-term memory in humans and animals is frequently assessed using delayed matching to sample (DMTS) and delayed nonmatching to sample (DNMTS) tasks across variable delay intervals. Although these tasks depend on certain common mechanisms, there are behavioral differences between them, and neuroimaging provides a means of assessing explicitly whether this is underpinned by differences at a neural level. Findings of delay-dependent deficits, after lesions in humans and animals, suggest that the neural implementation of these tasks may also critically depend on the delay interval. In this study we determined whether there were differential neural responses associated with DMTS and DNMTS tasks at two different delay intervals using functional magnetic resonance imaging. Ten healthy volunteers were studied under four test conditions: DMTS and DNMTS at 5 and 15 sec delay. The main effect of DMTS compared with DNMTS across both delay intervals was associated with significant activation in bilateral head of caudate and medial orbitofrontal cortex. By contrast, DNMTS compared with DMTS was associated with significant activation in mediodorsal thalamus, bilateral lateral orbitofrontal cortex, and left premotor cortex. The main effect of short compared with long delay, across both tasks, was associated with significantly greater activity in occipital and parietal cortices. By contrast, long compared with short delay was associated with significantly greater activity in temporal and ventrolateral frontal cortices. We conclude that DMTS and DNMTS are not equivalent and furthermore that the precise neural implementation of these tasks is a dynamic function of delay interval.
Diseases of Passion Flower (Passiflora spp.)

There may be many factors contributing to reduction in longevity and productivity in passion fruit plants, especially diseases of viral, bacterial or fungal etiologies, among which passion fruit woodiness, bacterial spot, root and collar rot, fusarium wilt, anthracnose and scab are the most important. The incidence of woody fruits in young plants totally compromises the productivity and quality of fruits. Fusariosis, root and collar rot have swept out entire crops, leading to irreversible wilt and consequent death of plants. Bacteriosis, anthracnose and scab cause severe losses under favorable environmental conditions and the absence of preventive control. The permanent incidence of diseases in some areas may turn the crop unprofitable, causing its periodical migration to new areas. This review will cover the main passion fruit diseases, their symptoms, etiology, epidemiology and management.
Agenda Building In Media Coverage of Food Research

Concern has been raised about the rising influence of public relations on scientific news coverage and the potential role of institutional sources in shaping news reports. This study uses quantitative content analysis and qualitative interviews to explore the influence of public relations activities on newspaper coverage of “superfoods” and, in particular, to explore the transparency of reporting of the sources of research funding. Superfoods were chosen as a case study because the term is applied to a wide range of foods with potential health benefits (e.g. foods high in antioxidants). Furthermore, foods labelled as “superfoods” have seen sharp increases in sales, suggesting a potential commercial incentive for such labelling. Analysis of a sample of news articles reporting superfoods revealed a considerable influence for media releases in shaping the content of reports, while less than a third of reports discussing research studies funded by organisations with a commercial interest in the findings mentioned the funding sources. Qualitative interviews confirmed the role of press offices in promoting research, particularly from scientific conferences, and suggest that scientific societies are applying less stringent criteria to studies selected for publication than in the past.
Antitubercular and Phytochemical Investigation of Methanol Extracts of Medicinal Plants Used by the Samburu Community in Kenya

Purpose: To determine the potential benefits of nine medicinal plants used by the Samburu community for the treatment of tuberculosis. Methods: The extract was tested against four strains of Mycobacteria namely; Mycobacterium tuberculosis (Mtb), M. Kansasii (Mk), M. fortuitum (Mf), and M. smegmatis (Ms) using BACTEC MGIT 960 system. The crude extracts were also analyzed for the presence of phytochemical constituents. Results: Both the extracts of Scadoxus multiflorus and Acacia nilotica showed strong antimycobacterial activity against the four tuberculosis-causing strains. Eurphobia scarlatina was the most active against both the slow (Mtb and Mk) and the fast (Mf and Ms) growers with Zero GUs at 0.5mg/ml. Phytochemical screening indicated presence or absence of tannins, saponins and flavonoids, terpenoids, cardiac glycosides and alkaloids in the extracts. Conclusion: The data suggest that some of the methanol extracts could be a rich source of antituberculosis agents. The results further show that there is some merit in the use of some of the plants studied in alternative medical practice. Pharmacological and toxicological studies of the active plants are still under investigation. Keywords: Medicinal plants, Methanol extract, Antituberculosis, Samburu.