Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Low-Dose Human Interferon-alpha on Shipping Fever of Thoroughbred Racehorses

To assess the effect of human interferon-alpha (IFNα) on shipping fever of Thoroughbred racehorses subjected to long-distance transportation, an IFNα preparation was orally administered to 48 horses three times (once daily, 3 successive days) before transportation (IFNα group). In the control group (25 horses), maltose was administered in the same way. These treatments induced no abnormal findings in Thoroughbred racehorses before transportation. Immediately after transportation, significant increases in rectal temperature were observed in both treatment groups, whereas the rectal temperature of the IFNα group tended to be lower than that of the control group. Although WBC, Fbg, and SAA immediately after transportation were significantly increased due to transportation in both groups, the extent of the increases in the IFNα group was significantly smaller than in the control group. Long-distance transportation had a relatively profound impact on Thoroughbred racehorses, which was mitigated by IFNα treatment.
Design and performance analysis of Fuzzy LQR; Fuzzy PID and LQR controller for active suspension system using 3 Degree of Freedom quarter car model

The aim of this research work is to design three types of active controller for active suspension system. A 3 Degree of Freedom (DOF) quarter car model is used to analyze and compare the performance characteristics of the active system with the uncontrolled system or passive suspension system. Suspension system plays an essential role in isolating vehicle body from road shocks and vibrations. The goal of suspension system is to improve ride comfort; road handling and stability of vehicles. The objective is to determine control strategy to deliver better performance with respect to seat velocity; suspension deflection; sprung mass displacement; sprung mass velocity; peak overshoot; settling time etc. The three controllers designed are LQR based fuzzy controller; Fuzzy PID controller and Linear Quadratic Controller (LQR). In this work; MATLAB/SIMULINK software is used for simulation purpose and simulation result shows that active suspension system exhibits better result than passive suspension system. Also the result of comparison shows that Fuzzy LQR controller based active suspension system gives better result and stability as compared to other active controllers and passive model.
Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys

The D2 dopamine (DA) receptor agonist, quinpirole, was characterized in young adult monkeys, young reserpine-treated monkeys and aged monkeys to assess the contribution of DA to age-related loss of prefrontal cortical (PFC) cognitive function. Monkeys were tested on a delayed response memory task that depends on the PFC, and a fine motor task that taps the functions of the motor cortex. In young adult monkeys, low quinpirole doses impaired performance of the PFC and fine motor tasks, while higher doses improved memory performance and induced dyskinesias and “hallucinatory-like” behaviors. The pattern of the quinpirole response in reserpine-treated monkeys suggested that the impairments in delayed response and fine motor performance resulted from drug actions at D2 autoreceptors, while the improvement in delayed response performance, dyskinesias and “hallucinatory-like” behaviors resulted from actions at postsynaptic receptors. In aged monkeys, low doses of quinpirole continued to impair fine motor performance, but lost their ability to impair delayed response performance. The magnitude of cognitive improvement and the incidence of “hallucinatory- like” behaviors were also reduced in the aged animals, suggesting some loss of postsynaptic D2 receptor function. The pattern of results is consistent with the greater loss of DA from the PFC than from motor areas in aged monkey brain (Goldman-Rakic and Brown, 1981; Wenk et al., 1989), and indicates that DA depletion contributes significantly to age- related cognitive decline.
Achievement in Large-Scale National Numeracy Assessment: An Ecological Study of Motivation and Student, Home, and School Predictors

With the rise of large-scale academic assessment programs around the world, there is a need to better understand the factors predicting students’ achievement in these assessment exercises. This investigation into national numeracy assessment drew on ecological and transactional conceptualizing involving student, student/home, and school factors. Student factors comprised mathematics ability, gender, and year group. Student/home factors comprised mathematics tutoring, mathematics competition participation, computer support for mathematics, and practice mathematics tests. School factors included school-average mathematics ability, school-average practice mathematics tests and competition participation, and socioeducational status. These educational ecology factors were modeled as predictors of mathematics motivation. In turn, educational ecology factors and mathematics motivation were modeled as predictors of numeracy achievement. Data were drawn from N = 12,736 Australian elementary (Years 3 and 5) and secondary (Years 7 and 9) school students from 231 schools participating in a national numeracy assessment exercise. Multilevel structural equation modeling revealed that student and student/home factors (Level 1) and school factors (Level 2) explained significant variance in student- and school-level mathematics motivation. In turn, these factors explained significant variance in student- and school-level numeracy achievement. Findings hold implications for the nature, breadth, and depth of efforts aimed at improving mathematics motivation and numeracy achievement in large-scale assessment programs.
Open Wilson lines and chiral condensates in thermal holographic QCD

We investigate various aspects of a proposal by Aharony and Kutasov [O. Aharony and D. Kutasov, Phys. Rev. D 78, 026005 (2008). ] for the gravity dual of an open Wilson line in the Sakai-Sugimoto model or its noncompact version. In particular, we use their proposal to determine the effect of finite temperature, as well as background electric and magnetic fields, on the chiral symmetry breaking order parameter. We also generalize their prescription to more complicated worldsheets and identify the operators dual to such worldsheets.
Mental imagery and fiction

Abstract Fictions evoke imagery, and their value consists partly in that achievement. This paper offers analysis of this neglected topic. Section 2 identifies relevant philosophical background. Section 3 offers a working definition of imagery. Section 4 identifies empirical work on visual imagery. Sections 5 and 6 criticize imagery essentialism, through the lens of genuine fictional narratives. This outcome, though, is not wholly critical. The expressed spirit of imagery essentialism is to encourage philosophers to ‘put the image back into the imagination’. The weakened conclusion is that while an image is not essential to imagining, it should be returned to our theories of imagination.
Equation of State and Opacities for Hydrogen Atmospheres of Neutron Stars with Strong Magnetic Fields

We present an equation of state and radiative opacities for a strongly magnetized hydrogen plasma at magnetic fields B, temperatures T, and densities ρ typical for atmospheres of isolated neutron stars. The first- and second-order thermodynamic functions, monochromatic radiative opacities, and Rosseland mean opacities are calculated and tabulated, taking account of partial ionization, for 8 × 1011 G ≤ B ≤ 3 × 1013 G, 2 × 105 K ≤ T ≤ 107 K, and a wide range of ρ. We show that bound-bound and bound-free transitions give an important contribution to the opacities at T ≲ (1-5) × 106 K in the considered range of B in the outer neutron star atmosphere layers, which may substantially modify the X-ray spectrum of a typical magnetized neutron star. In addition, we reevaluate opacities due to free-free transitions, taking into account the motion of both interacting particles, electron and proton, in a strong magnetic field. Compared to the previous neutron star atmosphere models, the free-free absorption is strongly suppressed at photon frequencies below the proton cyclotron frequency. The latter result holds for any field strength, which prompts a revision of existing theoretical models of X-ray spectra of magnetar atmospheres.
A New Milky Way Dwarf Galaxy in Ursa Major

In this Letter, we report the discovery of a new dwarf satellite to the Milky Way, located at (α2000, δ2000) = (158.°72, 51.°92) in the constellation of Ursa Major. This object was detected as an overdensity of red, resolved stars in Sloan Digital Sky Survey data. The color-magnitude diagram of the Ursa Major dwarf looks remarkably similar to that of Sextans, the lowest surface brightness Milky Way companion known, but with approximately an order of magnitude fewer stars. Deeper follow-up imaging confirms that this object has an old and metal-poor stellar population and is ~100 kpc away. We roughly estimate MV = -6.75 and r1/2 = 250 pc for this dwarf. Its luminosity is several times fainter than the faintest known Milky Way dwarf. However, its physical size is typical for dwarf spheroidal galaxies. Even though its absolute magnitude and size are presently quite uncertain, Ursa Major is likely the lowest luminosity and lowest surface brightness galaxy yet known.
Rasch analysis of the Locomotor Capabilities Index-5 in people with lower limb amputation

The aim of this study was to perform a Rasch analysis on the 5-level ordinal scale version of the Locomotor Capabilities Index (LCI-5), in order to investigate rating scale quality and conduct reliability and validity assessments. A questionnaire was mailed to 144 subjects who had undergone lower limb amputation (LLA) in the previous five years and completed a rehabilitation and prosthetic training programme. A total of 123 persons (85%) responded to the questionnaire, a self-report assessment of prosthetic capability and performance which included the LCI-5, the Mobility Section of the Prosthesis Evaluation Questionnaire (PEQ-MS) and other variables associated to prosthetic wear and use. Following Rasch analysis and expert review, the LCI-5 response categories level 1 (‘yes, if someone helps me’) and 2 (‘yes, if someone is near me’) were combined into a single category and 4 items were deleted (due to misfitting). The remaining 10 items fitted the Rasch model (LCI10-4) and demonstrated good reliability (person separation reliability = 0.94, item separation reliability = 0.98) and internal construct validity. Moreover, the good correlation with the PEQ-MS (rs = 0.77) and with prosthetic wear and use (rs range 0.34 – 0.51) supported the convergent validity of the scale. In conclusion, Rasch analysis provided the rationale for improving the measurement qualities of the LCI-5, refining its rating scale (through category diagnostics), identifying those items most useful for measuring the intended construct (as per the indexes of unidimensionality and internal construct validity) and showing that one can place high confidence in the consistency of both the person-ability and item-difficulty estimates obtained (reliability).
Interpretation Biases in Clinical Paranoia

Interpretation biases matching the concerns of a psychopathology have been implicated in the etiology of psychological disorders, but little research has investigated their presence in psychosis. Here we investigated negative, and specifically paranoia-relevant, interpretation biases in patients with schizophrenia, with (n = 32) and without (n = 29) paranoid symptoms and matched healthy controls (n = 29). Results revealed negatively biased interpretations of emotional ambiguity in both patient groups compared to controls—paranoid patients showing the stronger biases on material permitting paranoid interpretations than on other types of ambiguous material—but mixed evidence that this content-specific effect applied uniquely to the paranoid patient group. These data support models of psychopathology, including psychosis, which implicate cognitive biases in the formation and maintenance of core symptoms. We conclude that biased interpretation specifically related to paranoia deserves further detailed empirical investigation as a possible causal and maintaining factor for psychosis symptoms.
Paleoecological Perspectives on Fire Ecology: Revisiting the Fire-Regime Concept~!2009-09-02~!2009-11-09~!2010-03-05~!

Fire is well recognized as a key Earth system process, but its causes and influences vary greatly across spatial and temporal scales. The controls of fire are often portrayed as a set of superimposed triangles, with processes ranging from oxygen to weather to climate, combustion to fuel to vegetation, and local to landscape to regional drivers over broadening spatial and lengthening temporal scale. Most ecological studies and fire management plans consider the effects of fire-weather and fuels on local to sub-regional scales and time frames of years to decades. Fire reconstructions developed from high-resolution tree-ring records and lake-sediment data that span centuries to millennia offer unique insights about fire's role that cannot otherwise be obtained. Such records help disclose the historical range of variability in fire activity over the duration of a vegetation type; the role of large-scale changes of climate, such as seasonal changes in summer insolation; the consequences of major reorganizations in vegetation; and the influence of prehistoric human activity in different ecological settings. This paleoecological perspective suggests that fire-regime definitions, which focus on the characteristic frequency, size and intensity of fire and particular fuel types, should be reconceptualized to better include the controls of fire regimes over the duration of a particular biome. We suggest that approaches currently used to analyze fire regimes across multiple spatial scales should be employed to examine fire occurrence across multiple temporal scales. Such cross-scale patterns would better reveal the full variability of particular fire regimes and their controls, and provide relevant information for the types of fire regimes likely to occur in the future with projected climate and land-use change.
Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi

Invasive aspergillosis is a life-threatening mycosis caused by the pathogenic fungus Aspergillus. The predominant causal species is Aspergillus fumigatus, and azole drugs are the treatment of choice. Azole drugs approved for clinical use include itraconazole, voriconazole, posaconazole, and the recently added isavuconazole. However, epidemiological research has indicated that the prevalence of azole-resistant A. fumigatus isolates has increased significantly over the last decade. What is worse is that azole-resistant strains are likely to have emerged not only in response to long-term drug treatment but also because of exposure to azole fungicides in the environment. Resistance mechanisms include amino acid substitutions in the target Cyp51A protein, tandem repeat sequence insertions at the cyp51A promoter, and overexpression of the ABC transporter Cdr1B. Environmental azole-resistant strains harboring the association of a tandem repeat sequence and punctual mutation of the Cyp51A gene (TR34/L98H and TR46/Y121F/T289A) have become widely disseminated across the world within a short time period. The epidemiological data also suggests that the number of Aspergillus spp. other than A. fumigatus isolated has risen. Some non-fumigatus species intrinsically show low susceptibility to azole drugs, imposing the need for accurate identification, and drug susceptibility testing in most clinical cases. Currently, our knowledge of azole resistance mechanisms in non-fumigatus Aspergillus species such as A. flavus, A. niger, A. tubingensis, A. terreus, A. fischeri, A. lentulus, A. udagawae, and A. calidoustus is limited. In this review, we present recent advances in our understanding of azole resistance mechanisms particularly in A. fumigatus. We then provide an overview of the genome sequences of non-fumigatus species, focusing on the proteins related to azole resistance mechanisms.
Using frustration in the design of adaptive videogames

In efforts to attract a wider audience, videogames are beginning to incorporate adaptive gameplay mechanics. Unlike the more traditional videogame, adaptive games can cater the gaming experience to the individual user and not just a particular group of users as with the former. Affective videogames, games that respond to the user's emotional state, may hold the key to creating such gameplay mechanics. In this paper we discus how the emotion frustration may be used in the design of adaptive videogames and the ongoing research into its detection and measurement.
The Investment Model of Commitment Processes

The investment model of commitment processes is rooted in interdependence theory and emerged from the broader scientific zeitgeist of the 1960s and 1970s that sought to understand seemingly irrational persistence in social behavior. The investment model was developed originally to move social psychology beyond focusing only on positive affect in predicting persistence in a close interpersonal relationship. As originally tested, the investment model holds that commitment to a target is influenced by three independent factors: satisfaction level, quality of alternatives, and investment size. Commitment, in turn, is posited to mediate the effects of these three bases of dependence on behavior, including persistence. Commitment is presumed to bring about persistence by influencing a host of relationship maintenance phenomena. The investment model has proven to be remarkably generalizable across a range of commitment targets, including commitment toward both interpersonal (e.g., abusive relationships, friendships) and non-interpersonal (e.g., job, sports participation, support for public policies) targets. Empirical support for the investment model is presented as well as a review of recent applications of the model and a proposed extension of it.
The Effects of Female Shell Size on Reproductive Potential of the Egg Capsule in Rapa Whelk Rapana venosa in Three Regions of Different Salinities

We investigated the effects of shell height on reproductive potential of the female Rapana venosa in three regions of different salinities (the coastal zone of the Gwangyang Bay (S-1); the upper reaches (S-3); lower reaches (S-2) of the Seomjin River). The number of egg capsules, egg capsule height, and fecundity associated with reproductive potential of larger female rapa whelks were higher than those of smaller individuals in all three regions. Correlation analyses showed that there is a significant positive correlation between egg capsule and female shell height. Mean of shell heights, egg capsule heights, the number of egg capsules in an egg mass, and fecundity in an egg capsule produced from female individuals inhabiting S-1 region were markedly higher than those inhabiting S-2 and S-3 regions. In particular, the fecundity of the rapa whelk increased with the salinity and shell height. Although large rapa whelks produced a large number of egg capsules at S-1 region, those at S-3 habitat laid less egg capsules with smaller size. If these rapa whelks were put into S-2 region, the number of egg capsules produced by a female at S-2 region was slightly larger than those produced by a female at S-3 region. This provides a clear evidence that the number of the egg capsules can be controlled by the salinity. In the coastal zone of the Gwangyang Bay and the upper reaches of Seomjin River, the fecundity of this species was estimated to be approximately 182,000-1,302,000 eggs/ind. /yr.
Synthesis and Antimicrobial Evaluation of Some Novel Bis-α,β-Unsaturated Ketones, Nicotinonitrile, 1,2-Dihydropyridine-3-carbonitrile, Fused Thieno[2,3-b]pyridine and Pyrazolo[3,4-b]pyridine Derivatives

The title compounds were prepared by reaction of 1,1′-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)diethanone (1) with different aromatic aldehydes 2a–c, namely Furfural (2a), 4-chlorobenzaldehyde (2b) and 4-methoxybenzaldhyde (2c) to yield the corresponding α,β-unsaturated ketones 3a–c. Compound 3 was reacted with malononitrile, 2-cyanoacetamide or 2-cyanothioacetamide yielded the corresponding bis[2-amino-6-(aryl)nicotinonitrile] 4a–c, bis[6-(2-aryl)-2-oxo-1,2-dihydropyridine-3-carbonitrile] 5a–c or bis[6-(2-aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile] 6a,b, respectively. The reaction of compound 6a with each of 2-chloro-N-(4-bromophenyl) acetamide (7a), chloroacetamide (7b) in ethanolic sodium ethoxide solution at room temperature to give the corresponding 4,4′-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)bis-6-(2-furyl)thieno[2,3-b]pyridine-2-carboxamide] derivatives 9a,b. While compound 6a reacted with hydrazine hydrate yielded the 4,4′-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)bis[6-(2-furyl)-1H-pyrazolo[3,4-b]pyridin-3-amine] 11. The structures of the products were elucidated based on their spectral properties, elemental analyses and, wherever possible, by alternate synthesis. Antimicrobial evaluation of the products was carried out.
CRP-Cyclic AMP Dependent Inhibition of the Xylene-Responsive σ54-Promoter Pu in Escherichia coli

The expression of σ54-dependent Pseudomonas putida Pu promoter is activated by XylR activator when cells are exposed to a variety of aromatic inducers. In this study, the transcriptional activation of the P. putida Pu promoter was recreated in the heterologous host Escherichia coli. Here we show that the cAMP receptor protein (CRP), a well-known carbon utilization regulator, had an inhibitory effect on the expression of Pu promoter in a cAMP-dependent manner. The inhibitory effect was not activator specific. In vivo KMnO4 and DMS footprinting analysis indicated that CRP-cAMP poised the RNA polymerase at Pu promoter, inhibiting the isomerization step of the transcription initiation even in the presence of an activator. Therefore, the presence of PTS-sugar, which eliminates cAMP, could activate the poised RNA polymerase at Pu promoter to transcribe. Moreover, the activation region 1 (AR1) of CRP, which interacts directly with the αCTD (C-terminal domain of α-subunit) of RNA polymerase, was found essential for the CRP-mediated inhibition at Pu promoter. A model for the above observations is discussed.
Exploring psychological wellbeing in acting training: an Australian interview study*

Student actors in professional training are potentially vulnerable to difficulties with their psychological wellbeing, but there has been little research to date investigating the positive and negative impacts of this unique environment and training process. The current study uses contemporary psychological theory and qualitative methodology to explore the perceptions of both acting students and their trainers. Seven acting students and eight trainers from two institutions were interviewed in-depth and the data analysed using thematic analysis. The findings were clustered into three domains of experience: the conservatoire (environmental/cultural factors), acting training (process factors) and student qualities (individual factors). Influences on students’ psychological wellbeing included: complex personal relationships, intense workload, chronic uncertainty, perfectionism, personal strengths, mental health difficulties, identity destabilisation, growth and feeling exposed. An important unresolved question arose: when is acting training dangerous? Practical implications included: building mental health literacy, increasing students’ feelings of competence, fostering students’ ability to tolerate stress and uncertainty and employing a specialist clinician. There is vast scope for future research, particularly in clarifying the wellbeing challenges in training and identifying appropriate, evidence-based interventions for use in this unique environment.