Miracle-dz/UniFAR-FTUs huggingface dataset:
Do autumn leaf colours serve as a reproductive insurance against sucking herbivores

Although autumn leaf colours of deciduous trees have been shown to protect against photo-oxidative damage, they are sometimes seen as signals to pests and predators. Here I modify the coevolution hypothesis of autumn leaf colours. I suggest that much of the within-population variation in autumn leaf colours can be explained by differences in the allocation of resources to sexual reproduction. According to the novel hypothesis, reproductively active woody plants produce early and intense autumn leaf colours in order to protect seeds and other reproductive tissues from pests that lay eggs in the autumn. If many seeds mature at times of leaf senescence or during the next summer, a woody plant will reallocate plenty of nitrogen to seeds. If sucking insects reproduce on such hosts, their flightless offspring will suffer poor-quality food after the ripening of seeds. Before this, however, insects will probably concentrate around the ripening seeds to forage on nitrogen-rich veins. This will decline the quality and quantity of developing seeds. If, on the other hand, insects are able to recognize reproductively active plants while laying eggs in the autumn, both the insects and the plants benefit. The flightless offspring of insects feeds on plants that supply sufficiently nitrogen for longer than reproducing plants do, while these optimise their reproduction by avoiding pests, which also contributes to the abundance of specialist pests. Hence, I suppose that while physiological factors are the origin of autumnal colour changes of deciduous leaves, the visible cue utilized by insects has evolved several times to an honest signal that reveals the unsuitability of the potential host in the near future. The reproductive insurance hypothesis may help us to understand why bright autumn leaf colours are rare among herbaceous plants, and why plants at high altitudes and latitudes are often brightly coloured in autumn.
Bubbles in the ocean and their significance in ocean acoustics

Gas bubbles in water are among the most efficient sources of sound in nature when they oscillate as monopoles and as such provide the mechanism of sound generation for a diverse range of sources from underwater physical and biological processes. These include most of the natural and some of the introduced sources of sound in the ocean and other water masses. Bubbles also have a high scattering cross section and substantially affect the propagation of underwater sound and enhance the detectability of objects containing bubbles. The underwater sound measured from natural bubbles can be inverted to make estimates of wind speed and rain fall integrated over an area of the water surface and can also provide insight into transfer of gases across the air sea interface. This paper will discuss why bubbles are so effective in these respects, how they are responsible for most of the ambient noise in the ocean through many different sources, and how they are important in extracting information about processes within the ocean and in the vicinity of the ocean surface. BUBBLES AS SOURCES OF SOUND IN THE OCEAN The source strength of sound radiated from movement of a fluid interface that forms the boundary between a contrast in density or sound speed or both (such as air and water) is proportional to (Cato, 1991)
Evidence for the Involvement of Electrical, Calcium and ROS Signaling in the Systemic Regulation of Non-Photochemical Quenching and Photosynthesis

In contrast to the function of reactive oxygen species, calcium, hormones and small RNAs in systemic signaling, systemic electrical signaling in plants is poorly studied and understood. Pulse amplitude-modulated Chl fluorescence imaging and surface electrical potential measurements accompanied by pharmacological treatments were employed to study stimuli-induced electrical signals in leaves from a broad range of plant species and in Arabidopsis thaliana mutants. Here we report that rapid electrical signals in response to a local heat stimulus regulate systemic changes in non-photochemical quenching (NPQ) and PSII quantum efficiency. Both stimuli-induced systemic changes in NPQ and photosynthetic capacity as well as electrical signaling depended on calcium channel activity. Use of an Arabidopsis respiratory burst oxidase homolog D (RBOHD) mutant (rbohD) as well as an RBOH inhibitor further suggested a cross-talk between ROS and electrical signaling. Our results suggest that higher plants evolved a complex rapid long-distance calcium-dependent electrical systemic signaling in response to local stimuli that regulates and optimizes the balance between PSII quantum efficiency and excess energy dissipation in the form of heat by means of NPQ.
Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy

Somatic variants are a recognized cause of epilepsy‐associated focal malformations of cortical development (MCD). We hypothesized that somatic variants may underlie a wider range of focal epilepsy, including nonlesional focal epilepsy (NLFE). Through genetic analysis of brain tissue, we evaluated the role of somatic variation in focal epilepsy with and without MCD.
Effects of hypoxic training on physiological exercise intensity and recognition of exercise intensity in young men

This study aimed to examine the effects of hypoxic training on physiological exercise intensity and recognition of exercise intensity in young men. The participants included 9 healthy young males (23.2 ± 6.5 years old, 176.2 ±6.7 cm, 74.3 ±16.4 kg). VO2 was measured during running with subjective exercise intensities of “somewhat hard” for 3 min and “fairly light” for 3 min. After the measurements, the participants answered the question “what percentage of your maximal effort was performed during both running exercises. ” The exercise intensity recognition for the “fairly light” and “somewhat hard” intensities and the physiological exercise intensity measured by relative VO2 (%) and relative heart rate (HR, %) were then evaluated. The hypoxic training was performed 3 times a week for 4 weeks in a normobaric hypoxic chamber (oxygen concentration, 15.4% and altitude, 2500 m). The participants ran at an exercise intensity of 60% VO2max for 40 min after a 5 min warm-up and then performed a 5 min cool-down. After training, they sat on a chair in the same room for 30 min. VO2max and HRmax changed significantly after the training. At “fairly light” intensity, the physiological measures were significantly higher than recognition of exercise intensity, with relative VO2 (%) increasing after training. In conclusion, hypoxia training causes an increase in VO2max and physiological exercise intensity during running at a “fairly light” intensity.
Utilizing Animal Models of Infantile Spasms

Infantile spasms are a devastating epileptic encephalopathy characterized by early life spasms and later seizures. Clinical outcomes of infantile spasms are poor and therapeutic options are limited with significant adverse effects. Therefore, new strategies to treat infantile spasms are of the utmost importance. Animals models of infantile spasms are a critical component of developing new therapies. Here, we review current chronic animal models of infantile spasms and consider future advances that may help improve patient care, as well as our scientific understanding of this debilitating disease.
Nutlin‐3a as a novel anticancer agent for adrenocortical carcinoma with CTNNB1 mutation

Adrenocortical carcinoma (ACC) is a rare malignancy, and CTNNB1 is frequently mutated in ACC. Our study aims to screen for effective agents with antineoplastic activity against ACC with CTNNB1 mutation. In‐silico screening of the Genomics of Drug Sensitivity in Cancer (GDSC) database was conducted. Drug sensitivity in cells with CTNNB1 mutation was analyzed and further in vitro and in vivo studies were performed using the compound. Only one compound, Nutlin‐3a, an MDM2 inhibitor, was significantly sensitive in 18 cancer cells with CTNNB1 mutation. Further analysis of the 18 cells revealed no significant efficacy between cells with both CTNNB1 and TP53 mutations indicating concomitant TP53 mutation did not impact on drug efficacy. We verified that Nutlin‐3a inhibited cellular proliferation in ACC cell line NCI‐H295R which harbored CTNNB1 mutation but not in SW13 cells which did not. Nutlin‐3a induced cell apoptosis and G1 cell‐cycle arrest in NCI‐H295R cells. Nutlin‐3a also decreased cellular migration and inhibited epithelial‐to‐mesenchymal transition (EMT) process in terms of EMT index. Nutlin‐3a resulted in decreased β‐catenin level independent of p53 level in NCI‐H295R but not SW13 cells. We also evaluated the effect of Nutlin‐3a on hormonal secretion of NCI‐H295R cells and found it resulted in decreased levels of cortisol, androgen, and progesterone. Nutlin‐3a treatment inhibited ACC tumor growth with no observed toxicity in mice in vivo. Our study has revealed that Nutlin‐3a potently inhibits ACC with CTNNB1 mutation. How p53/MDM2 axis coordinates with Wnt/beta‐Catenin signaling in ACC warrants further study.
Protecting Activity and Free Radical Scavenging Activity of Anthocyanins from Red Sorghum ( Sorghumbicolor ) Bran

There is increasing interest in natural food colorants like carotenoids and anthocyanins with functional properties. Red sorghum bran is known as a rich source for anthocyanins. The anthocyanin contents extracted from red sorghum bran were evaluated by biochemical analysis. Among the three solvent system used, the acidified methanol extract showed a highest anthocyanin content (4.7 mg/g of sorghum bran) followed by methanol (1.95 mg/g) and acetone (1 mg/g). Similarly, the highest total flavonoids (143 mg/g) and total phenolic contents (0.93 mg/g) were obtained in acidified methanol extracts than methanol and acetone extracts. To study the health benefits of anthocyanin from red sorghum bran, the total antioxidant activity was evaluated by biochemical and molecular methods. The highest antioxidant activity was observed in acidified methanol extracts of anthocyanin in dose-dependent manner. The antioxidant activity of the red sorghum bran was directly related to the total anthocyanin found in red sorghum bran.
Bone Mineral Density Measurements, Bone Markers and Serum Vitamin D Concentrations in Men with Chronic Non-Cirrhotic Untreated Hepatitis C

Introduction The high prevalence of chronic hepatitis C (CHC) and its consequent cirrhosis has been associated with bone fragility. Whether CHC may cause bone and mineral abnormalities in the absence of hepatocellular dysfunction is still unknown. In this study we aimed to determine the prevalence of osteoporotic vertebral fractures and low BMD measurements in men with non-cirrhotic CHC. Risk factors for low BMD and fractures were also investigated. Methods Morphometric vertebral fractures and BMD measurements were performed in 60 non-cirrhotic untreated men with CHC and 59 healthy controls, matched for age and gender, weight and current smoking. Serum CTx, calcium, phosphate, intact PTH, alkaline phosphatase and vitamin D (25OHD) concentrations were measured in all participants. Clinical risk factors for low BMD and fractures were evaluated by a structured questionnaire as well as details regarding HCV infection. Results Trochanter and total femur BMD were significantly lower in CHC patients as compared to healthy men (p = 0.04). In men 50 years and older, the prevalence of osteoporosis was significantly higher among CHC patients (p = 0.01). Lower levels of physical activities and more often report of prolonged immobilization were observed among CHC patients (p<0.05). Liver inflammation and fibrosis, viral load and genotype did not correlate with BMD measurements. Bone markers and 25OHD concentrations were similar in both groups. Only a few vertebral fractures were observed. Conclusions Our results demonstrate that non-cirrhotic untreated CHC patients have lower BMD at the femur as compared to healthy men in spite of the absence of significant bone and mineral abnormalities.
Application of mesenchymal stem cells to enhance non-union bone fracture healing.

ECM components include a number of osteoinductive and osteoconductive factors, which are involved in bone fracture healing. In this study, a combination of adipose derived mesenchymal stem cells (Ad-MSCs), cancellous bone graft (CBG), and chitosan hydrogel (CHI) was applied to the non-union bone fracture and healing effects were evaluated for the first time. After creation of animal models with non-union fracture in rats, they were randomly classified into seven groups. Radiography at 0, 2, 4, and 8 weeks after surgery, indicated the positive effects of Ad-MSCs + CBG + CHI and Ad-MSCs + CBG in treatment of bone fractures as early as 2 weeks after the surgery. These data were confirmed with both biomechanical and histological studies. Gene expression analyses of Vegf and Bmp2 showed a positive effect of Ad-MSCs on vascularization and osteogenic differentiation in all groups receiving Ad-MSCs, as shown by real-time PCR. Immunofluorescence analysis and RT-PCR results indicated existence of human Ad-MSCs in the fractured region 8 weeks post-surgery. In conclusion, we suggest that application of Ad-MSCs, CBG, and CHI, could be a suitable combination for osteoinduction and osteoconduction to improve non-union bone fracture healing. Further investigations are required to determine the exact mechanisms involved in this process before moving to clinical studies. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 301-311, 2019.
Omega-3 Fatty Acid Supplementation Improves Heart Rate Variability in Obese Children

Obese children and adolescents are at high risk of developing cardiovascular diseases later in life. We hypothesized that cardiovascular prophylaxis with omega-3 fatty acids could benefit them. In our study, 20 children and adolescents (mean body mass index percentile: 99.1; mean age: 11.0 years) underwent two ambulatory 24 h Holter electrocardiography (ECG) recordings (before and after at least 3 months of omega-3 fatty acid supplementation). Time domain heart rate variability (HRV) and heart rate (HR) were examined for these patients. As a control, we used 24 h Holter ECG recordings of 94 nonobese children and adolescents. Time domain HRV parameters, which are indicators of vagal stimulation, were significantly lower in obese patients than in healthy controls, but HR was higher (standard deviation of the normal-to-normal [SDNN] interbeat intervals: −34.02%; root mean square of successive differences [RMSSD] between normal heartbeats: −40.66%; percentage of consecutive RR intervals [pNN50]: −60.24%; HR: +13.37%). After omega-3 fatty acid supplementation, time domain HRV parameters and HR of obese patients were similar to the values of healthy controls (SDNN interbeat intervals: −21.73%; RMSSD: −19.56%; pNN50: −25.59%; HR: +3.94%). Therefore, omega-3 fatty acid supplementation may be used for cardiovascular prophylaxis in obese children and adolescents.
Two-photon absorption in layered transition metal dichalcogenides

Two-dimensional (2D) layered transition metal dichalcogenides (TMDCs) exhibit unique nonlinear optical (NLO) features and have becoming intriguing and promising candidate materials for photonic and optoelectronic devices with high performance and unique functions. Owing to layered geometry and the thickness-dependent bandgap, we studied the ultrafast NLO properties of a range of TMDCs. TMDCs with high-quality layered nanosheets were prepared through chemical vapor deposition (CVD) technique and vapor-phase growth method. Saturable absorption, two photon absorption (TPA) and two photon pumped frequency up-converted luminescence were observed from these 2D nanostructures. The exciting results open up the door to 2D photonic devices, such as passive mode-lockers, Q-switchers, optical limiters, light emitters, etc.
Mediterranean diet and cognitive decline

Abstract Objective: To investigate the possible role of diet in age-related cognitive decline (ARCD) and cognitive impairment of both degenerative (Alzheimer's disease, AD) and vascular (vascular dementia, VaD) origin. Design: Literature review. Results: In an elderly population of southern Italy with a typical Mediterranean diet, high energy intake of monounsaturated fatty acids (MUFA) appeared to be associated with a high level of protection against ARCD. In addition, dietary fat and energy in the elderly seem to be risk factors, while fish consumption and cereals are found to reduce the prevalence of AD in European and North American countries. Finally, the relative risk of dementia (AD and VaD) was lower in the subjects of a French cohort who drank three or four glasses of red wine each day compared with total abstainers. Conclusion: Essential components of the Mediterranean diet – MUFA, cereals and wine – seem to be protective against cognitive decline. As such, dietary antioxidants and supplements, specific macronutrients of the Mediterranean diet, oestrogens and anti-inflammatory drugs may act synergistically with other protective factors, opening up new therapeutic interventions for cognitive decline.
Effect of sex, menstrual cycle phase, and monophasic oral contraceptive pill use on local and central arterial stiffness in young adults.

Arterial stiffness is associated with increased cardiovascular disease risk. Previous sex-based investigations of local and central stiffness report inconsistent findings and have not controlled for menstrual cycle phase in women. There is also evidence that sex hormones influence the vasculature, but their impact on arterial stiffness across a natural menstrual (NAT) or oral contraceptive pill (OCP) cycle has been understudied. This study sought to 1) examine potential sex differences in local and central stiffness, 2) compare stiffness profiles between NAT and OCP cycles, and 3) investigate the relationship between duration of OCP use and arterial stiffness. Sex hormone concentrations, β-stiffness index (local stiffness), and carotid-femoral pulse wave velocity [cfPWV (central stiffness)] were assessed in 53 healthy adults (22 ± 3 yr old, 20 men, 15 NAT women, and 18 OCP women). All participants were tested three times: men on the same day and time 1 wk apart, NAT women in menstrual, midfollicular and luteal phases of the menstrual cycle, and OCP women in placebo, early active and late active pill phases. β-Stiffness was higher in men than NAT and OCP women ( P < 0.001), whereas cfPWV was similar between groups ( P = 0.09). β-Stiffness and cfPWV did not differ across or between NAT and OCP cycles ( P > 0.05 for both) and were not associated with duration of OCP use (β-stiffness: r = 0.003, P = 0.99; cfPWV: r = -0.26, P = 0.30). The apparent sex differences in local, but not central, stiffness highlight the importance of assessing both indexes in comparisons between men and women. Furthermore, fluctuating sex hormone levels do not appear to influence β-stiffness or cfPWV. Therefore, these stiffness indexes may need to be assessed during only one cycle phase in women in future investigations. NEW & NOTEWORTHY We observed higher local, but not central, arterial stiffness in men than women. We also demonstrated that there are no differences in arterial stiffness between naturally cycling women and women who use monophasic oral contraceptive pills, and that the duration of oral contraceptive pill use does not influence arterial stiffness.
Characteristics of Electrical Signals in Poplar and Responses in Photosynthesis1

To gain an understanding of the role of electrical signaling in trees, poplar (Populus trichocarpa, Populus tremula × P. tremuloides) shoots were stimulated by chilling as well as flaming. Two kinds of signal propagation were detected by microelectrode measurements (aphid technique) in the phloem of leaf veins: (1) basipetal, short-distance signaling that led to rapid membrane hyperpolarization caused by K+-efflux within the leaf lamina; and (2) acropetal, long-distance signaling that triggered depolarization of the membrane potential in the leaf phloem. In the latter, the depolarizing signals travel across the stem from the manipulated leaves to adjacent leaves where the net CO2 uptake rate is temporarily depressed toward compensation. With regard to photosystem II, both heat-induced long-distance and short-distance signaling were investigated using two-dimensional “imaging” analysis of chlorophyll fluorescence. Both types of signaling significantly reduced the quantum yield of electron transport through photosystem II. Imaging analysis revealed that the signal that causes yield reduction spreads through the leaf lamina. Coldblocking of the stem proved that the electrical signal transmission via the phloem becomes disrupted, causing the leaf gas exchange to remain unaffected. Calcium-deficient trees showed a marked contrast inasmuch as the amplitude of the electrical signal was distinctly reduced, concomitant with the absence of a significant response in leaf gas exchange upon flame wounding. In summary, the above results led us to conclude that calcium as well as potassium is involved in the propagation of phloem-transmitted electrical signals that evoke specific responses in the photosynthesis of leaves.
Starburst and AGN activity in ultraluminous infrared galaxies

We examine the power source of 41 local Ultraluminous Infrared Galaxies (ULIRGs) using archival infrared (IR) and optical photometry. We fit the observed Spectral Energy Distributions (SEDs) with starburst and AGN components; each component being drawn from a family of templates. We find all of the sample require a starburst, whereas only half require an AGN. In 90% of the sample the starburst provides over half the IR emission, with a mean fractional luminosity of 82%. When combined with other galaxy samples we find that starburst and AGN luminosities correlate over 6 decades in IR luminosity suggesting that a common factor governs both luminosities, plausibly the gas masses in the nuclear regions. We find no trend for increasing fractional AGN luminosity with increasing total luminosity, contrary to previous claims. We find that the mid-IR F7.7/C7.7 line-continuum ratio is no indication of the starburst luminosity, or the fractional AGN luminosity, and therefore that F7.7/C7.7 is not a reliable diagnostic of the power source in ULIRGs. The radio flux correlates with the starburst luminosity, but shows no correlation with the AGN luminosity, in line with previous results. We propose that the scatter in this correlation is due to a skewed starburst IMF and/or relic relativistic electrons from a previous starburst, rather than contamination from an obscured AGN. We show that most ULIRGs undergo multiple starbursts during their lifetime, and by inference that mergers between more than two galaxies may be common amongst ULIRGs. Our results support the evolutionary model for ULIRGs proposed by Farrah et al (2001), where they can follow many different evolutionary paths of starburst and AGN activity in transforming merging spiral galaxies into elliptical galaxies, but that most do not go through an optical QSO phase. The lower level of AGN activity in our local sample than in z � 1 HLIRGs implies that the two samples are distinct populations. We postulate that different galaxy formation processes at high-z are responsible for this difference.
Market Microstructure, Banks' Behaviour, and Interbank Spreads

We present an empirical analysis of the European electronic interbank market of overnight lending (e-MID) during the years 1999–2009. The main goal of the paper is to explain the observed changes of the cross-sectional dispersion of lending/borrowing conditions before, during and after the 2007–2008 subprime crisis. Unlike previous contributions, that focused on banks’ dependent and macro information as explanatory variables, we address the role of banks’ behaviour and market microstructure as determinants of the credit spreads.