Miracle-dz/UniFAR-FTUs huggingface dataset:
Allocation of time in communities of practice: A strategy to enhance continuing professional teachers’ development of high schools teachers’

Abstract The paper investigates allocation of time as strategy established by communities of practice to enhance continuing professional teachers’ development in selected high schools. Having sufficient time by teachers to collaborate together and learn is essential to enhancing their professional development. The study adopted qualitative research approach and case study research design. Findings revealed that time allocated for communities of practice are limited which do not enable teachers to have opportunity to learn as a team. The study concluded that teachers do not have sufficient time to engage in collaborative learning activities. It is recommended that teachers should spend adequate time for learning activities in communities of practice. Regular and fixed time should be allocated for communities of practice such that teachers will have enough time to collaborate. Teachers should meet at least once in a week for a minimum of 1 hour in schools for communities of practice.
Camera egomotion estimation in the ADAS context

Camera-based Advanced Driver Assistance Systems (ADAS) have concentrated many research efforts in the last decades. Proposals based on monocular cameras require the knowledge of the camera pose with respect to the environment, in order to reach an efficient and robust performance. A common assumption in such systems is considering the road as planar, and the camera pose with respect to it as approximately known. However, in real situations, the camera pose varies along time due to the vehicle movement, the road slope, and irregularities on the road surface. Thus, the changes in the camera position and orientation (i.e., the egomotion) are critical information that must be estimated at every frame to avoid poor performances. This work focuses on egomotion estimation from a monocular camera under the ADAS context. We review and compare egomotion methods with simulated and real ADAS-like sequences. Basing on the results of our experiments, we show which of the considered nonlinear and linear algorithms have the best performance in this domain.
An Integrated Specification Logic for Cyber-Physical Systems

Cyber-physical systems denote a new modeling paradigm that promotes a holistic view on complex systems. These systems have been studied before from various particular perspectives using paradigms like ubiquitous and distributed computing or embedded and hybrid systems. In modeling cyber-physical systems one has to consider the interaction between physics, computation and communication (networking), and a formal framework to studythis systems has to be invented. In this paper we develop a formal approach called Hilbertean formal methods to provide a denotational semantics for cyber-physical systems. We combine denotational semantics with an algebraic model for physical processes to model physical causality and observability.
Influence of cortisol on zinc metabolism in morbidly obese women.

Introduction: The accumulation of visceral fat affects the metabolism of hormones and some nutrients, but these mechanisms remain unclear. Objective: To assess the influence of cortisol on the metabolism of zinc in morbidly obese women. Method: Cross-sectional, case-control study involving 80 women aged between 20 and 59 years. The participants were divided into two groups: experimental (morbidly obese, n = 40) and control (normal weight, n = 40). Zinc concentrations were determined by atomic absorption spectroscopy and serum and urinary cortisol by chemiluminescence method. Results: Zinc intake was significantly different between groups. Mean plasma zinc was lower in obese compared to control group. Mean values for erythrocyte zinc were 44.52 ± 7.84 μg/gHb and 40.17 ± 6.71 μg/gHb for obese and control groups, respectively. Urinary excretion of this mineral was higher in obese compared to control subjects (p 0.05). The correlation analysis between cortisol and zinc was not significant (p > 0.05). Conclusions: Obese patients have hypozincemia and high erythrocyte zinc levels. The correlation between zinc parameters and cortisol concentration showed no influence of this hormone on zinc metabolism.
Monetary Policy Shocks and Portfolio Choice

The paper shows that monetary policy shocks exert a substantial effect on the size and composition of capital flows and the trade balance for the United States, with a 100 basis point easing raising net capital inflows and lowering the trade balance by 1% of GDP, and explaining about 20-25% of their time variation. Monetary policy easing causes positive returns to both equities and bonds. Yet such a monetary policy easing shock also induces a shift in portfolio composition out of equities and into bonds, implying a negative conditional correlation between flows in equities and bonds. Moreover, such shocks induce a negative conditional correlation between equity flows and equity returns, but a positive conditional correlation between bond flows and bond returns. The findings thus provide evidence for the presence of a portfolio rebalancing motive behind investment decisions in equities, but the dominance of what is akin to a return chasing motive for bonds, conditional on monetary policy shocks. The results also shed light on the puzzle of the strongly time-varying equity-bond return correlations found in the literature.
The MVA Pre-empt resume priority approximation

A Mean Value Analysis (MVA) approximation is presented for computing the average performance measures of closed multiclass queueing networks containing non pre-emptive Head Of Line (HOL) and Pre-empt Resume (PR) priority centers. The approximation has the same storage and computational requirements as MVA thus allowing computationally efficient solutions of large priority queueing networks. The accuracy of the MVA PR approximation is systematically investigated and presented in terms of error contour diagrams. The contour diagrams reveal that the approximation can compute the average performance measures of priority networks to within an accuracy of 5 percent for a large range of network parameter values. Accuracy of the method is also compared to Sevcik's shadow approximation and another MVA approximation recently proposed by Chandy and Lakshmi.
The British General Election of 2010: The Results Analysed

The 2010 election was fought against the backdrop of both economic recession and political scandal. Yet although the incumbent Labour government was clearly rejected by the voters, the principal opposition party, the Conservatives made only a modest advance. Fewer voters backed one or other the two largest parties than ever before. Meanwhile, for only the second time since 1945, no one party secured an overall majority. In this paper we analyse the constituency level election results in order to identify possible explanations of the parties’ performances and to account for the outcome in seats.
LP 400-22, a Very Low Mass and High-Velocity White Dwarf

We report the identification of LP 400-22 (WD 2234+222) as a very low mass and high-velocity white dwarf. The ultraviolet GALEX and optical photometric colors and a spectral line analysis of LP 400-22 show this star to have an effective temperature of 11,080 ± 140 K and a surface gravity of log g = 6.32 ± 0.08. Therefore, this is a helium-core white dwarf with a mass of 0.17 M☉. The tangential velocity of this white dwarf is 414 ± 43 km s-1, making it one of the fastest moving white dwarfs known. We discuss probable evolutionary scenarios for this remarkable object.
Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases

The central event in protein misfolding disorders (PMDs) is the accumulation of a misfolded form of a naturally expressed protein. Despite the diversity of clinical symptoms associated with different PMDs, many similarities in their mechanism suggest that distinct pathologies may cross talk at the molecular level. The main goal of this study was to analyze the interaction of the protein misfolding processes implicated in Alzheimer's and prion diseases. For this purpose, we inoculated prions in an Alzheimer's transgenic mouse model that develop typical amyloid plaques and followed the progression of pathological changes over time. Our findings show a dramatic acceleration and exacerbation of both pathologies. The onset of prion disease symptoms in transgenic mice appeared significantly faster with a concomitant increase on the level of misfolded prion protein in the brain. A striking increase in amyloid plaque deposition was observed in prion-infected mice compared with their noninoculated counterparts. Histological and biochemical studies showed the association of the two misfolded proteins in the brain and in vitro experiments showed that protein misfolding can be enhanced by a cross-seeding mechanism. These results suggest a profound interaction between Alzheimer's and prion pathologies, indicating that one protein misfolding process may be an important risk factor for the development of a second one. Our findings may have important implications to understand the origin and progression of PMDs.
μ-Opioid Receptors within Subregions of the Striatum Mediate Pair Bond Formation through Parallel Yet Distinct Reward Mechanisms

The prairie vole is a socially monogamous rodent that is an excellent animal model for studies of the neurobiology of social attachment. Such studies have demonstrated that activation of reward circuitry during social interactions facilitates pair bond formation. Within this circuitry, μ-opioid receptors (MORs) modulate naturally rewarding behavior in an anatomically segregated manner; MORs located throughout the striatum (dorsal striatum, NAc core, and the entire NAc shell) are implicated in general motivational processes, whereas those located specifically within the dorsomedial NAc shell mediate positive hedonics (and are referred to as a “hedonic hotspot”). The purpose of the present study was to determine whether MORs within these distinct subregions differentially mediate pair bond formation. We first used receptor autoradiography to compare MOR binding densities between these regions. MOR binding was significantly higher in the NAc core and dorsomedial NAc shell compared with the ventral NAc shell. We next used partner preference testing to determine whether MORs within these subregions differentially mediate pair bonding. Blockade of MORs using 1 or 3 μg of H-d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2 within the dorsal striatum decreased mating during the cohabitation period and inhibited partner preference formation. In contrast, blockade of MORs within dorsomedial NAc shell inhibited partner preference formation without effecting mating behavior, whereas other regions were not involved. Thus, MORs within the dorsal striatum mediate partner preference formation via impairment of mating, whereas those in the dorsomedial NAc shell appear to mediate pair bond formation through the positive hedonics associated with mating.
Surgical Outcomes for Primary Rhegmatogenous Retinal Detachments in Patients with Pseudophakia after Phacoemulsification

Purpose To evaluate the clinical features and surgical outcomes for primary rhegmatogenous retinal detachments (RDs) in patients with pseudophakia after phacoemulsification. Methods The medical records of patients with pseudophakia after phacoemulsification and intraocular lens implantation who had undergone surgery for primary rhegmatogenous RDs with a minimum duration of follow-up of 12 months were reviewed retrospectively. Results A total of 104 patients were enrolled in this study and 106 eyes were analyzed. Post-operative retinal attachment was achieved in 87 of the eyes (82.1%) and the final visual acuities (logarithm of the minimum angle of resolution) were improved to 0.65 ± 0.49 from the baseline measurement of 1.51 ± 1.14 (p < 0.001). Re-operations were performed in 24 of the eyes (22.6%) and there were no visible retinal breaks in 30 of the eyes (28.3%). The failure to identify a retinal break during surgery was associated with a lower rate of retinal reattachment, worse final visual acuity, and a higher rate of re-operation (p = 0.002, p = 0.02, and p = 0.002, respectively). The location of the identified retinal break was more common in the superotemporal quadrant than in the other quadrants. Conclusions The inability to identify a retinal break during surgery was associated with a poor final outcome. Other factors were less important for the functional and anatomic success in patients with pseudophakic RDs.
Trapped Torsional Vibrations in Elastic Plates

It was observed that torsional vibrations can be trapped in elastic plates with circular regions of slightly thicker steps or with smooth convex contoured surfaces. An electromagnetic acoustic transducer (EMAT) was used to generate oscillatory surface traction. The resonant frequencies and Q-values were measured. It was found that these trapped torsional modes have Q-values exceeding 100,000 with pure in-plane motion, which is of practical importance for acoustic sensor applications. In this paper, a set of approximate two-dimensional equations is developed to study vibrations in axisymmetrically contoured or stepped elastic plates. By assuming circumferentially independent motion, the first-order equations are decoupled into four groups, with torsional modes uncoupled from flexural and extensional modes. Analytical solutions for torsional modes are obtained for stepped and linearly contoured circular plates. It is found that the first-order torsional modes can be trapped in an infinite plate with a stepped or contoured region if critical conditions for the geometrical parameters are met. The analytical results are compared to experiments and finite element analyses with good agreements
Improving Network Intrusion Detection by Means of Domain-Aware Genetic Programming

One of the central areas in network intrusion detection is how to build effective systems that are able to distinguish normal from intrusive traffic. In this paper we explore the use of Genetic Programming (GP) for such a purpose. Although GP has already been studied for this task, the inner features of network intrusion detection have been systematically ignored. To avoid the blind use of GP shown in previous research, we guide the search by means of a fitness function based on recent advances on IDS evaluation. For the experimental work we use a well-known dataset (i.e. KDD-99) that has become a standard to compare research although its drawbacks. Results clearly show that an intelligent use of GP achieves systems that are comparable (and even better in realistic conditions) to top state-of-the-art proposals in terms of effectiveness, improving them in efficiency and simplicity.
Application of radiosurgical techniques to produce a primate model of brain lesions

Behavioral analysis of subjects with discrete brain lesions provides important information about the mechanisms of various brain functions. However, it is generally difficult to experimentally produce discrete lesions in deep brain structures. Here we show that a radiosurgical technique, which is used as an alternative treatment for brain tumors and vascular malformations, is applicable to create non-invasive lesions in experimental animals for the research in systems neuroscience. We delivered highly focused radiation (130–150 Gy at ISO center) to the frontal eye field (FEF) of macaque monkeys using a clinical linear accelerator (LINAC). The effects of irradiation were assessed by analyzing oculomotor performance along with magnetic resonance (MR) images before and up to 8 months following irradiation. In parallel with tissue edema indicated by MR images, deficits in saccadic and smooth pursuit eye movements were observed during several days following irradiation. Although initial signs of oculomotor deficits disappeared within a month, damage to the tissue and impaired eye movements gradually developed during the course of the subsequent 6 months. Postmortem histological examinations showed necrosis and hemorrhages within a large area of the white matter and, to a lesser extent, in the adjacent gray matter, which was centered at the irradiated target. These results indicated that the LINAC system was useful for making brain lesions in experimental animals, while the suitable radiation parameters to generate more focused lesions need to be further explored. We propose the use of a radiosurgical technique for establishing animal models of brain lesions, and discuss the possible uses of this technique for functional neurosurgical treatments in humans.
Performance analysis and comparison of ZF and MRT based downlink massive MIMO systems

In this paper the performances of zero-forcing (ZF) and maximum ratio transmission (MRT) are analyzed and compared in a downlink massive multiple-input multiple-output system. The system employs a large number of base station antennas serving multiple user terminals within the same cell. The achievable sum rate and the required downlink transmit power using each of the precoding schemes are derived, analyzed and compared under the same conditions and assumptions. Simulation results are found to coincide with the theoretical results, and show that ZF performs better than MRT under the same conditions.
An emerging role for adenosine and its receptors in bone homeostasis

Bone is continually being remodeled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodeling but other mechanisms, hitherto unknown, may also be involved. Importantly, our understanding of these currently unknown mechanisms may lead to important new therapies for bone disease. It is accepted that purinergic signaling is involved in bone, and our knowledge of this area has increased significantly over the last 15 years, although most of the published work has studied the role of ATP and other signaling molecules via the P2 family of purinergic receptors. During the last few years, however, there has been increased interest within the bone field in the role of P1 receptors where adenosine is the primary signaling molecule. This review will bring together the current information available in relation to this expanding area of research.
Automatic Database Clustering Using Data Mining

Because of data proliferation, efficient access methods and data storage techniques have become increasingly critical to maintain an acceptable query response time. One way to improve query response time is to reduce the number of disk I/Os by partitioning the database vertically (attribute clustering) and/or horizontally (record clustering). A clustering is optimized for a given set of queries. However in dynamic systems the queries change with time, the clustering in place becomes obsolete, and the database needs to be re-clustered dynamically. In this paper we discuss an efficient algorithm for attribute clustering that dynamically and automatically generate attribute clusters based on closed item sets mined from the attributes sets found in the queries running against the database
Adaptive Intrusion Response to Minimize Risk over Multiple Network Attacks

A new risk-minimizing security model is presented for distributed network intrusion detection with automated responses. The scheme is based on collective risk assessment of multiple attacks on a network. We propose a new adaptive alarm/defense framework in protecting network resources. We have tested the adaptive security framework on a small Linux cluster at USC. The desired security functions are distributed to routers, switches, firewalls, and hosts. Adaptive response strategies are suggested based on the alarm confidence, attack frequency, assessed risks, and estimated response costs. Dynamic security is achieved by frequent policy update against changing attack patterns or varying network conditions. Measured false alarms and detection rate are used in the armed response decision process. This paper reports the theoretical framework and experimental results obtained. Lessons learned from this network security project are presented.
Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines

The Scutellaria species (Lamiaceae) is used as a source of flavonoids to treat a variety of diseases in traditional medicine. In spite of many reports about the cytotoxic and antitumor effects of some species of this genus, anticancer researches on one of the Iranian species S. litwinowii have not yet been conducted. The cytotoxic properties of total methanol extract of S. litwinowii and its fractions were investigated on different cancer cell lines including AGS, HeLa, MCF-7, PC12 and NIH 3T3. Meanwhile, the role of apoptosis in this toxicity was explored. The cells were cultured in DMEM medium and incubated with different concentrations of herb plant extracts. Cell viability was quantitated by MTT assay. Apoptotic cells were determined using propidium iodide staining of DNA fragmentation by flow cytometry (sub-G1 peak). Scutellaria litwinowii inhibited the growth of malignant cells in a dose-dependent manner. Among solvent fractions of S. litwinowii, the methylene chloride fraction was found to be more toxic compared to other fractions. The IC50 values of this fraction against AGS, HeLa, MCF-7 and PC12 cell lines after 24 h were determined, 121.2 ± 3.1, 40.9 ± 2.5, 115.9 ± 3.5 and 64.5 ± 3.4 μg/ml, respectively. Scutellaria litwinowii induced a sub-G1 peak in the flow cytometry histogram of treated cells compared to control cells indicating that apoptotic cell death is involved in S. litwinowii toxicity. Scutellaria litwinowii exerts cytotoxic and proapototic effects in a variety of malignant cell lines and could be considered as a potential chemotherapeutic agent in cancer treatment.
Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex

The mammalian cerebral cortex comprises six layers of neurons. Cortical progenitors in the ventricular zone generate neurons specific to each layer through successive cell divisions. Neurons of layer VI are generated at an early stage, whereas later-born neurons occupy progressively upper layers. The underlying molecular mechanisms of neurogenesis, however, are relatively unknown. In this study, we devised a system where the Notch pathway was activated spatiotemporally in the cortex by in vivo electroporation and Cre-mediated DNA recombination. Electroporation at E13.5 transferred DNA to early progenitors that gave rise to neurons of both low and upper layers. Forced expression of a constitutively active form of Notch (caNotch) at E13.5 inhibited progenitors from generating neurons and kept progenitors as proliferating radial glial cells. After subsequent transfection at E15.5 of a Cre expression vector to remove caNotch, double-transfected cells, in which caNotch was excised, migrated into the cortical plate and differentiated into neurons specific to upper layers. Bromodeoxyuridine-labeling experiments showed that the neurons were born after Cre transfection. These results indicate that cortical progenitors that had been temporarily subjected to Notch activation at an early stage generated neurons at later stages, but that the generation of low-layer neurons was skipped. Moreover, the double-transfected cells gave rise to upper-layer neurons, even after their transplantation into the E13.5 brain, indicating that the developmental state of progenitors is not halted by caNotch activity.