Miracle-dz/UniFAR-FTUs huggingface dataset:
Approaches to minimize overhang angles of SLM parts

Purpose For geometries exhibiting overhanging surfaces, support structures are needed to dissipate process heat and to minimize geometrical distortions attributed to internal stresses. The use of support structures is often time- and cost-consuming. For this reason, this study aims to propose an approach which minimizes the use of such structures. Design/methodology/approach For minimizing the use of support structures, process parameters in combination with a contour-like exposure strategy are developed to realize support-less overhanging structures of less than 35°. These parameters are implemented in a shell-core strategy, which follows the idea of applying different processing strategies to the critical (overhanging) shell and the uncritical core of the part. Thereby, the core is processed with standard parameters, aiming a dense material. On the critical shell, optimized processing parameters are applied, reaching good results in terms of surface quality, especially at extreme overhang situations. Findings The results show that the selective laser melting (SLM) technology is able to realize support-less overhanging surfaces by choosing suitable scan strategies and process parameters. Particularly good results are always obtained when the exposure direction of the shell is parallel to the contour of the sample. Originality/value The validity of the results is demonstrated through the successful reproduction of the build strategy on two commercial SLM machines, reaching support-free builds of surfaces with an angle to the horizontal of less than or equal to 30°.
Nurses' knowledge and skill retention following cardiopulmonary resuscitation training: a review of the literature.

AIM This paper reports a literature review examining factors that enhance retention of knowledge and skills during and after resuscitation training, in order to identify educational strategies that will optimize survival for victims of cardiopulmonary arrest. BACKGROUND Poor knowledge and skill retention following cardiopulmonary resuscitation training for nursing and medical staff has been documented over the past 20 years. Cardiopulmonary resuscitation training is mandatory for nursing staff and is important as nurses often discover the victims of in-hospital cardiac arrest. Many different methods of improving this retention have been devised and evaluated. However, the content and style of this training lack standardization. METHOD A literature review was undertaken using the Cumulative Index to Nursing and Allied Health Literature, MEDLINE and British Nursing Index databases and the keywords 'cardiopulmonary resuscitation', 'basic life support', 'advanced life support' and 'training'. Papers published between 1992 and 2002 were obtained and their reference lists scrutinized to identify secondary references, of these the ones published within the same 10-year period were also included. Those published in the English language that identified strategies to enhance the acquisition or retention of Cardiopulmonary resuscitation skills and knowledge were included in the review. RESULTS One hundred and five primary and 157 secondary references were identified. Of these, 24 met the criteria and were included in the final literature sample. Four studies were found pertaining to cardiac arrest simulation, three to peer tuition, four to video self-instruction, three to the use of different resuscitation guidelines, three to computer-based learning programmes, two to voice-activated manikins, two to automated external defibrillators, one to self-instruction, one to gaming and the one to the use of action cards. CONCLUSIONS Resuscitation training should be based on in-hospital scenarios and current evidence-based guidelines, including recognition of sick patients, and should be taught using simulations of a variety of cardiac arrest scenarios. This will ensure that the training reflects the potential situations that nurses may face in practice. Nurses in clinical areas, who rarely see cardiac arrests, should receive automated external defibrillation training and have access to defibrillators to prevent delays in resuscitation. Staff should be formally assessed using a manikin with a feedback mechanism or an expert instructor to ensure that chest compressions and ventilations are adequate at the time of training. Remedial training must be provided as often as required. Resuscitation training equipment should be made available at ward/unit level to allow self-study and practice to prevent deterioration between updates. Video self-instruction has been shown to improve competence in resuscitation. An in-hospital scenario-based video should be devised and tested to assess the efficacy of this medium in resuscitation training for nurses.
SPECTRAL VARIATIONS OF THE SKY: CONSTRAINTS ON ALTERNATE UNIVERSES

The fine tuning of parameters required to reproduce our present day universe suggests that our universe may simply be a region within an eternally inflating super-region. Many other regions beyond our observable universe would exist with each such region governed by a different set of physical parameters. Collision between these regions, if they occur, should leave signatures of anisotropy in the cosmic microwave background (CMB) but have not been seen. We analyze the spectral properties of masked, foreground-cleaned maps between 100 and 545 GHz constructed from the Planck data set. Four distinct ∼2°–4° regions associated with CMB cold spots show anomalously strong 143 GHz emission but no correspondingly strong emission at either 100 or 217 GHz. The signal to noise of this 143 GHz residual emission is at the ≳6σ level which reduces to 3.2–5. 4σ after subtraction of remaining synchrotron/free–free foregrounds. We assess different mechanisms for this residual emission and conclude that although there is a 30% probability that noise fluctuations may cause foregrounds to fall within 3σ of the excess, there is less than a 0.5% probability that foregrounds can explain all the excess. A plausible explanation is that the collision of our universe with an alternate universe whose baryon to photon ratio is a factor of ∼4500 larger than ours, could produce enhanced hydrogen Paschen-series emission at the epoch of recombination. Future spectral mapping and deeper observations at 100 and 217 GHz are needed to mitigate systematics arising from unknown Galactic foregrounds and to confirm this unusual hypothesis.
Degranulation, membrane addition, and shape change during chemotactic factor-induced aggregation of human neutrophils

Neutrophils stimulated by the chemotactic factor formyl-methionyl- leucyl-phenyl-alanine (FMLP) undergo a transient change in surface properties that permits the cells to adhere more readily to surfaces and to each other. This transient change can be monitored by light scattering as stimulated neutrophils form aggregates while stirred in a platelet aggregometer. Maximum change in light scattering occurs within 1 min and correlates with an increase in the percentage of cells that are in aggregates of four or more cells and a decrease in the percentage of single cells. With time (3-5 min), small aggregates disappear and single cells reappear. The transient change in adhesiveness is accompanied by a persistent change in cell shape; the cells become polarized and protrude ruffles from one sector of the cell surface. During aggregation the cells adhere to one another with smooth sides together and ruffles pointed outward. During disaggregation the cells dissociate laterally with the simultaneous internalization of membrane in the region opposite the ruffles. Particle bound to the surface by charge (thorotrast, cationized ferritin) are concentrated and internalized in this region. The change in cell shape from round to ruffled occurs within seconds, suggesting that membrane is added to the cell surface from an intracellular store. We therefore quantified surface membrane by electron microscopy morphometry and measured a 25% increase within 10 s of adding FMLP. The source of new membrane appeared to be the specific granule membrane since the kinetics of granule discharge (between 30% and 50% of all release occurs in the first 10 s) correlate with the appearance of new membrane. Furthermore, the amount of membrane that appears at the cell surface at 10 s correlates with that lost from intracellular granules in that time. Chemotaxin-induced aggregation thus begins with granule discharge and membrane addition followed by protrusion of ruffles. Adherence is maximal at 60 s and the gradual loss of adhesiveness that follows is associated with uropod formation and enhanced endocytic activity.
Integration of Motor Proteins – Towards an ATP Fueled Soft Actuator

We present a soft bio-machine constructed from biological motors (actin/myosin). We have found that chemically cross-linked polymer-actin complex gel filaments can move on myosin coated surfaces with a velocity as high as that of native F-actin, by coupling to ATP hydrolysis. Additionally, it is shown that the velocity of polymer-actin complex gel depends on the species of polycations binding to the F-actins. Since the design of functional actuators of well-defined size and morphology is important, the structural behavior of polymer-actin complexes has been investigated. Our results show that the morphology and growth size of polymer-actin complex can be controlled by changes in the electrostatic interactions between F-actins and polycations. Our results indicate that bio actuators with desired shapes can be created by using a polymer-actin complex.
Securing the Internet of Things: A proposed framework

These days Internet of Things (Internet of things) has transformed into a serious ponder that has made progress in the practically every field we can imagine. The following research paper gives a review of Internet of things, its empowering innovations, developing applications and security issues in the remote advancements. There are colossal number of uses of Internet of things in practically every part of life i.e. medicinal services, coordinations and production network administration, shrewd environment and social application and so forth along these lines security is an essential worry of remote systems thus it is one of the principle issues in Internet of things. The following paper gives an outline of the many security worries in an Internet of things framework, dangers related to it, difficulties and techniques to avoid such security issues.
Documents and Dependencies: an Exploration of Vector Space Models for Semantic Composition

In most previous research on distributional semantics, Vector Space Models (VSMs) of words are built either from topical information (e.g., documents in which a word is present), or from syntactic/semantic types of words (e.g., dependency parse links of a word in sentences), but not both. In this paper, we explore the utility of combining these two representations to build VSM for the task of semantic composition of adjective-noun phrases. Through extensive experiments on benchmark datasets, we find that even though a type-based VSM is effective for semantic composition, it is often outperformed by a VSM built using a combination of topic- and type-based statistics. We also introduce a new evaluation task wherein we predict the composed vector representation of a phrase from the brain activity of a human subject reading that phrase. We exploit a large syntactically parsed corpus of 16 billion tokens to build our VSMs, with vectors for both phrases and words, and make them publicly available.
Cantú syndrome: Report of nine new cases and expansion of the clinical phenotype

Cantú syndrome, a rare disorder of congenital hypertrichosis, characteristic facial anomalies, cardiomegaly, and osteochondrodysplasia was first described in 1982 by Cantú. Twenty‐three cases of Cantú syndrome have been reported to date. The pathogenesis of this rare autosomal dominant condition is unknown. We describe 10 patients with Cantú syndrome (9 new cases and the long‐term follow‐up of a 10th case reported by Robertson in 1999) comparing the phenotype with that of the previously reported cases. We describe how the distinctive facial appearance evolves with time and report several new findings including recurrent infections with low immunoglobulin levels and gastric bleeding in some of our patients. The cardiac manifestations include patent ductus arteriosus, septal hypertrophy, pulmonary hypertension, and pericardial effusions. They may follow a benign course, but of the 10 cases we report, 4 patients required surgical closure of the patent ductus arteriosus and 1 patient a pericardectomy. Long‐term follow‐up of these patients has shown reassuring neuro‐developmental outcome and the emergence of a behavior phenotype including obsessive traits and anxiety. © 2011 Wiley‐Liss, Inc.
Evidence for involvement of metalloendoproteases in a step in sea urchin gamete fusion

Membrane fusion events are required in three steps in sea urchin fertilization: the acrosome reaction in sperm, fusion of the plasma membrane of acrosome-reacted sperm with the plasma membrane of the egg, and exocytosis of the contents of the egg cortical granules. We recently reported the involvement of a Zn2+-dependent metalloendoprotease in the acrosome reaction (Farach, H. C., D. I. Mundy, W. J. Strittmatter, and W. J. Lennarz. 1987. J. Biol. Chem. 262:5483-5487). In the current study, we investigated the possible involvement of metalloendoproteases in the two other fusion events of fertilization. The use of inhibitors of metalloendoproteases provided evidence that at least one of the fusion events subsequent to the acrosome reaction requires such enzymes. These inhibitors did not block the binding of sperm to egg or the process of cortical granule exocytosis. However, sperm-egg fusion, assayed by the ability of the bound sperm to establish cytoplasmic continuity with the egg, was inhibited by metalloendoprotease substrate. Thus, in addition to the acrosome reaction, an event in the gamete fusion process requires a metalloendoprotease.
Solvated docking: introducing water into the modelling of biomolecular complexes

MOTIVATION Interfacial water, which plays an important role in mediating biomolecular interactions, has been neglected in the modelling of biomolecular complexes. METHODS We present a solvated docking approach that explicitly accounts for the presence of water in protein-protein complexes. Our solvated docking protocol is based on the concept of the first encounter complex in which a water layer is present in-between the molecules. It mimics the pathway from this initial complex towards the final assembly in which most waters have been expelled from the interface. Docking is performed from solvated biomolecules and waters are removed in a biased Monte Carlo procedure based on water-mediated contact propensities obtained from an analysis of high-resolution crystal structures. RESULTS We demonstrate the feasibility of this approach for protein-protein complexes representing both 'wet' and 'dry' interfaces. Solvated docking leads to improvements both in quality and scoring. Water molecules are recovered that closely match the ones in the crystal structures. AVAILABILTY Solvated docking will be made available in the future release of HADDOCK version 2.0 (http://www.nmr.chem.uu.nl/haddock).
Population-based Study of Kawasaki Disease Shock Syndrome in Taiwan

By using a National Health Insurance database, we investigated the occurrence of Kawasaki disease (KD) shock syndrome in Taiwan. KD shock syndrome occurred most frequently in winter, and the incidence was 1.45 per 100 patients with KD. Compared with KD patients without shock, KD shock syndrome patients were older, more likely to develop coronary lesions (15.9% vs. 7.0%) and had longer hospitalization duration.
The Silkworm Mutant lemon (lemon lethal) Is a Potential Insect Model for Human Sepiapterin Reductase Deficiency*

Tetrahydrobiopterin (BH4) is an essential cofactor for aromatic acid hydroxylases, which control the levels of monoamine neurotransmitters. BH4 deficiency has been associated with many neuropsychological disorders. An inherited defect in BH4 biosynthesis is caused by the deficiency of sepiapterin reductase (SPR), which catalyzes the biosynthesis of BH4 from guanosine triphosphate at the terminal step. The human SPR gene has been mapped at the PARK3 locus, which is related to the onset of Parkinson disease. In this study, we report that mutant strains, lemon (lem) and its lethal allele lemon lethal (lem1) with yellow body coloration, of the silkworm Bombyx mori could be used as the first insect model for human SPR deficiency diseases. We demonstrated that mutations in the SPR gene (BmSpr) were responsible for the irregular body coloration of lem and leml. Moreover, biochemical analysis revealed that SPR activity in leml larvae was almost completely diminished, resulting in a lethal phenotype that the larvae cannot feed and that die immediately after the first ecdysis. Oral administration of BH4 and dopamine to leml larvae effectively increased their survival rates and feeding abilities. Our data demonstrate that BmSPR plays a crucial role in the generation of BH4, and monoamine neurotransmitters in silkworms and the lem (leml) mutant strains will be an invaluable resource to address many questions regarding SPR and BH4 deficiencies.
On-the-fly attestation of reconfigurable hardware

This paper presents a novel method to perform on-the-fly attestation of hardware structures loaded to reconfigurable devices. Given that a loadable hardware structure to a reconfigurable device is described by a binary bitstream, the hash value of this bitstream can be calculated to validate the hardware structure. To optimize this attestation, the hash value computation is implemented in hardware on the FPGA itself. To guarantee the integrity of the existing computation architecture, the proposed hardware module also enforces region delimitation. With the region delimitation, only the regions intended to be reconfigured can be modified. Implementation results suggest that this bitstream attestation can be performed without imposing an extra delay to the reconfigurable process and at an area cost of less that 10% of a Virtex II Pro 30 FPGA device.
Serum Uric Acid as a Predictor for Development of Diabetic Nephropathy in Type 1 Diabetes

OBJECTIVE Experimental and clinical studies have suggested that uric acid may contribute to the development of hypertension and kidney disease. Whether uric acid has a causal role in the development of diabetic nephropathy is not known. The objective of the present study is to evaluate uric acid as a predictor of persistent micro- and macroalbuminuria. RESEARCH DESIGN AND METHODS This prospective observational follow-up study consisted of an inception cohort of 277 patients followed from onset of type 1 diabetes. Of these, 270 patients had blood samples taken at baseline. In seven cases, uric acid could not be determined; therefore, 263 patients (156 men) were available for analysis. Uric acid was measured 3 years after onset of diabetes and before any patient developed microalbuminuria. RESULTS During a median follow-up of 18.1 years (range 1.0–21.8), 23 of 263 patients developed persistent macroalbuminuria (urinary albumin excretion rate >300 mg/24 h in at least two of three consecutive samples). In patients with uric acid levels in the highest quartile (>249 μmol/l), the cumulative incidence of persistent macroalbumnuria was 22.3% (95% CI 10.3–34.3) compared with 9.5% (3.8–15.2) in patients with uric acid in the three lower quartiles (log-rank test, P = 0.006). In a Cox proportional hazards model with sex and age as fixed covariates, uric acid was associated with subsequent development of persistent macroalbuminuria (hazard ratio 2.37 [95% CI 1.04–5.37] per 100 μmol/l increase in uric acid level; P = 0.04). Adjustment for confounders did not change the estimate significantly. CONCLUSIONS Uric acid level soon after onset of type 1 diabetes is independently associated with risk for later development of diabetic nephropathy.
Genetics Selection Evolution Accuracy of Breeding Values of 'unrelated' Individuals Predicted by Dense Snp Genotyping

Background: Recent developments in SNP discovery and high throughput genotyping technology have made the use of high-density SNP markers to predict breeding values feasible. This involves estimation of the SNP effects in a training data set, and use of these estimates to evaluate the breeding values of other 'evaluation' individuals. Simulation studies have shown that these predictions of breeding values can be accurate, when training and evaluation individuals are (closely) related. However, many general applications of genomic selection require the prediction of breeding values of 'unrelated' individuals, i.e. individuals from the same population, but not particularly closely related to the training individuals.
Non-collision conditions in multi-agent robots formation using local potential functions

An analysis of the convergence and non-collision conditions of a formation control strategy for multi-agent robots based on local potential functions is presented. The goal is to coordinate a group of agents, considered as points in plane, to achieve a particular formation. The control law is designed using local attractive forces only where every agent knows the position of another two agents reducing the requirements of the control law implementation. The control law guarantees the convergence to the desired formation but does not avoid inter-agent collisions. A set of necessary and sufficient non- collision conditions based on the explicit solution of the closed- loop system is derived. The conditions allow to conclude from the initial conditions whether or not the agents will collide. The formal proof is presented for the case of three agents. The result is extended to the case of formations of three unicycles.
Evaluation of BILBO reference parsing in digital humanities via a comparison of different tools

Automatic bibliographic reference annotation involves the tokenization and identification of reference fields. Recent methods use machine learning techniques such as Conditional Random Fields to tackle this problem. On the other hand, the state of the art methods always learn and evaluate their systems with a well structured data having simple format such as bibliography at the end of scientific articles. And that is a reason why the parsing of new reference different from a regular format does not work well. In our previous work, we have established a standard for the tokenization and feature selection with a less formulaic data such as notes. In this paper, we evaluate our system BILBO with other popular online reference parsing tools on a new data from totally different source. BILBO is constructed with our own corpora extracted and annotated from real world data, digital humanities articles of Revues.org site (90% in French) of OpenEdition. The robustness of BILBO system allows a language independent tagging result. We expect that this first attempt of evaluation will motivate the development of other efficient techniques for the scattered and less formulaic bibliographic references.