Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimal timing of a PETTLEP mental imagery intervention on a dart throwing task

Research supports the use of mental imagery (MI) to increase performance on subsequent motor tasks. Elite athletes, coaches, and sport psychologists agree that MI is effective in positively influencing performance. Recent neuroscience research has established that there is functional equivalence in brain structures when using MI to imagine executing a task and physically executing the same task. To maximize functional equivalence in a MI intervention, Holmes and Collins (2001) introduced the PETTLEP model of MI. Despite overwhelming evidence for the effectiveness of PETTLEP MI, little is known about the optimal time-of-day to practice MI to influence subsequent performance to the highest degree. This study assesses the best time-of-day to use PETTLEP MI to maximize performance in a dart throwing task. Participants for this study included (n=30) undergraduate students that received a one session PETTLEP MI intervention immediately prior to the task (preparatory MI) or 12 hours prior to the task, including 8 hours of nighttime sleep. Data was collected by totaling scores on the dart throwing task based on accuracy and consistency. Baseline scores were compared to post-intervention test scores. The results of a repeated-measures analysis of variance (ANOVA) for dart throwing performance indicated no significant improvement in accuracy (p >.05) or consistency (p >.05) following the PETTLEP MI intervention. Further analysis revealed no significant dart throwing improvement for accuracy (p >.05) or consistency (p >.05) based on the timing of PETTLEP MI intervention, indicating no difference in the change from pre-test to post-test between preparatory and consolidation PETTLEP MI groups. These findings suggest that a single session PETTLEP MI intervention for dart throwing is not sufficient to see performance improvements. Although significant results were not found, future PETTLEP MI interventions should consider the use of additional PETTLEP training sessions, the inclusion of skilled performers doing a task they are familiar with, and assessing sleep characteristics, as participants in the current study were found to be poor and disordered sleepers.
New Algorithmic Approaches for Computing Optimal Network Paths with Several Types of QoS Constraints

The problem of efficiently delivering data within networks is very important nowadays, especially in the context of the large volumes of data which are being produced each year and of the increased data access needs of the users. Efficient data delivery strategies must satisfy several types of Quality of Service (QoS) constraints which are imposed by the data consumers. One possibility of achieving this goal (particularly in the case of in-order data transfers) is to choose a satisfactory network delivery path. In this paper we present novel algorithmic approaches for computing optimal network paths which satisfy several types of (QoS) constraints.
DBpedia spotlight: shedding light on the web of documents

Interlinking text documents with Linked Open Data enables the Web of Data to be used as background knowledge within document-oriented applications such as search and faceted browsing. As a step towards interconnecting the Web of Documents with the Web of Data, we developed DBpedia Spotlight, a system for automatically annotating text documents with DBpedia URIs. DBpedia Spotlight allows users to configure the annotations to their specific needs through the DBpedia Ontology and quality measures such as prominence, topical pertinence, contextual ambiguity and disambiguation confidence. We compare our approach with the state of the art in disambiguation, and evaluate our results in light of three baselines and six publicly available annotation systems, demonstrating the competitiveness of our system. DBpedia Spotlight is shared as open source and deployed as a Web Service freely available for public use.
Distinct Neurochemical and Functional Properties of GAD67-Containing 5-HT Neurons in the Rat Dorsal Raphe Nucleus

The serotonergic (5-HTergic) system arising from the dorsal raphe nucleus (DRN) is implicated in various physiological and behavioral processes, including stress responses. The DRN is comprised of several subnuclei, serving specific functions with distinct afferent and efferent connections. Furthermore, subsets of 5-HTergic neurons are known to coexpress other transmitters, including GABA, glutamate, or neuropeptides, thereby generating further heterogeneity. However, despite the growing evidence for functional variations among DRN subnuclei, relatively little is known about how they map onto neurochemical diversity of 5-HTergic neurons. In the present study, we characterized functional properties of GAD67-expressing 5-HTergic neurons (5-HT/GAD67 neurons) in the rat DRN, and compared with those of neurons expressing 5-HTergic molecules (5-HT neurons) or GAD67 alone. While 5-HT/GAD67 neurons were absent in the dorsomedial (DRD) or ventromedial (DRV) parts of the DRN, they were selectively distributed in the lateral wing of the DRN (DRL), constituting 12% of the total DRL neurons. They expressed plasmalemmal GABA transporter 1, but lacked vesicular inhibitory amino acid transporter. By using whole-cell patch-clamp recording, we found that 5-HT/GAD67 neurons had lower input resistance and firing frequency than 5-HT neurons. As revealed by c-Fos immunohistochemistry, neurons in the DRL, particularly 5-HT/GAD67 neurons, showed higher responsiveness to exposure to an open field arena than those in the DRD and DRV. By contrast, exposure to contextual fear conditioning stress showed no such regional differences. These findings indicate that 5-HT/GAD67 neurons constitute a unique neuronal population with distinctive neurochemical and electrophysiological properties and high responsiveness to innocuous stressor.
Defining changeability: Reconciling flexibility, adaptability, scalability, modifiability, and robustness for maintaining system lifecycle value

Designing and maintaining systems in a dynamic contemporary environment requires a rethinking of how systems provide value to stakeholders over time. Developing either changeable or classically robust systems are approaches to promoting value sustainment. But ambiguity in definitions across system domains has resulted in an inability to specify, design, and verify to ilities that promote value sustainment. In order to develop domain‐neutral constructs for improved system design, the definitions of flexibility, adaptability, scalability, modifiability, and robustness are shown to relate to the core concept of “changeability,” described by three aspects: change agents, change effects, and change mechanisms. In terms of system form or function parameter changes, flexibility and adaptability reflect the location of the change agent—system boundary external or internal respectively. Scalability, modifiability, and robustness relate to change effects, which are quantified differences in system parameters before and after a change has occurred. The extent of changeability is determined using a tradespace network formulation, counting the number of possible and decision‐maker acceptable change mechanisms available to a system, quantified as the filtered outdegree. Designing changeable systems allows for the possibility of maintaining value delivery over a system lifecycle, in spite of changes in contexts, thereby achieving value robustness. © 2008 Wiley Periodicals, Inc. Syst Eng
Temporal lobe interictal epileptic discharges affect cerebral activity in “default mode” brain regions

A cerebral network comprising precuneus, medial frontal, and temporoparietal cortices is less active both during goal‐directed behavior and states of reduced consciousness than during conscious rest. We tested the hypothesis that the interictal epileptic discharges affect activity in these brain regions in patients with temporal lobe epilepsy who have complex partial seizures. At the group level, using electroencephalography‐correlated functional magnetic resonance imaging in 19 consecutive patients with focal epilepsy, we found common decreases of resting state activity in 9 patients with temporal lobe epilepsy (TLE) but not in 10 patients with extra‐TLE. We infer that the functional consequences of TLE interictal epileptic discharges are different from those in extra‐TLE and affect ongoing brain function. Activity increases were detected in the ipsilateral hippocampus in patients with TLE, and in subthalamic, bilateral superior temporal and medial frontal brain regions in patients with extra‐TLE, possibly indicating effects of different interictal epileptic discharge propagation. Hum Brain Mapp 2006. © 2006 Wiley‐Liss, Inc.
A phase 2 study evaluating the efficacy and safety of a novel, proprietary, nano-formulated, lower dose oral diclofenac.

BACKGROUND Safety concerns associated with nonsteroidal anti-inflammatory drugs (NSAIDs) have prompted the development of new formulations that minimize adverse events (AEs) and maintain efficacy. OBJECTIVES To determine the analgesic efficacy and safety of an investigational, proprietary, nano-formulated, oral diclofenac (nano-formulated diclofenac) compared with placebo in subjects with acute dental pain. METHODS A Phase 2, multisite, randomized, double-blind, single-dose, parallel-group, active- and placebo-controlled study was carried out in 202 subjects (18-50 years old) who had extraction of ≥2 third molars (≥1 had to be a fully or partially impacted mandibular third molar) and experienced moderate to severe pain intensity ≤6 hours postsurgery (NCT00985439). Subjects received nano-formulated diclofenac 35 mg or 18 mg, celecoxib 400 mg, or placebo. The primary efficacy variable was the sum of total pain relief (TOTPAR) over 0-12 hours (TOTPAR-12) after Time 0. Secondary end points included TOTPAR over 0-4 hours (TOTPAR-4), TOTPAR over 0-8 hours (TOTPAR-8), and time to onset of analgesia. RESULTS Mean ± standard deviation TOTPAR-12 for nano-formulated diclofenac 35 mg and 18 mg, celecoxib, and placebo were 16.81 ± 12.76, 17.76 ± 13.76, 14.61 ± 15.05, and 5.65 ± 11.53, respectively (P < 0.001, nano-formulated diclofenac compared with placebo). Similar improvements were observed for TOTPAR-4, TOTPAR-8, mean time to first perceptible pain relief (P < 0.001), and peak relief (P < 0.05). Celecoxib treatment was not statistically different than placebo for these latter two parameters. Treatment-emergent AEs were similar across all treatment groups. CONCLUSIONS Lower dose, nano-formulated diclofenac demonstrated good overall efficacy, prompt pain relief, and was well tolerated. These data suggest lower dose nano-formulated NSAIDs could be effective for acute pain and may potentially improve safety and tolerability as a result of using a lower overall dose.
HUBUNGAN ANTARA DEPRESI DAN PROKRASTINASI AKADEMIK

Depresi merupakan reaksi yang muncul akibat stress dalam peristiwa hidup seseorang (Qonitatin, Widyawati, & Asih, 2011). Prokrastinasi akademik merupakan penundaan pengerjaan tugas secara irasional (Steel, 2007). Penelitian ini bertujuan untuk melihat hubungan antara depresi dan prokrastinasi akademik. Selain itu, dilihat juga pengaruh Temporal Motivation Theory (TMT) dalam menjelaskan hubungan kedua variabel. Subjek penelitian ini adalah mahasiswa Fakultas Psikologi Universitas Surabaya angkatan 2012. Metode pengambilan data menggunakan angket skala depresi yang diadaptasi dari Beck Depression Inventory (BDI-II), alat ukur prokrastinasi yaitu Irrational Procrastination Scale (IPS) dan alat ukur Steel Procrastinastion Scale (SPS). Hasilnya menunjukkan bahwa terdapat korelasi positif antara depresi dan prokrastinasi akademik (r=0.362, p=0.000). Hal ini menunjukkan bahwa semakin tinggi tingkat depresi seseorang semakin tinggi pula tingkat prokrastinasi akademik yang dilakukan. Selain itu, dari ketiga aspek TMT, impulsiveness yang memiliki pengaruh dalam menjelaskan hubungan antara depresi dan prokrastinasi akademik.
folding stability and specificity ? Do conformational biases of simple helical junctions influence RNA Material Supplemental

Structured RNAs must fold into their native structures and discriminate against a large number of alternative ones, an especially difficult task given the limited information content of RNA’s nucleotide alphabet. The simplest motifs within structured RNAs are two helices joined by nonhelical junctions. To uncover the fundamental behavior of these motifs and to elucidate the underlying physical forces and challenges faced by structured RNAs, we computationally and experimentally studied a tethered duplex model system composed of two helices joined by flexible singleor double-stranded polyethylene glycol tethers, whose lengths correspond to those typically observed in junctions from structured RNAs. To dissect the thermodynamic properties of these simple motifs, we computationally probed how junction topology, electrostatics, and tertiary contact location influenced folding stability. Small-angle X-ray scattering was used to assess our predictions. Singleor double-stranded junctions, independent of sequence, greatly reduce the space of allowed helical conformations and influencing the preferred location and orientation of their adjoining helices. A double-stranded junction guides the helices along a hinge-like pathway. In contrast, a single-stranded junction samples a broader set of conformations and has different preferences than the double-stranded junction. In turn, these preferences determine the stability and distinct specificities of tertiary structure formation. These sequence-independent effects suggest that properties as simple as a junction’s topology can generally define the accessible conformational space, thereby stabilizing desired structures and assisting in discriminating against misfolded structures. Thus, junction topology provides a fundamental strategy for transcending the limitations imposed by the low information content of RNA primary sequence.
“I couldn’t change the past; the answer wasn’t there”: A case study on the subjective construction of psychotherapeutic change of a patient with a Borderline Personality Disorder diagnosis and her therapist

Abstract Background: Qualitative research has provided knowledge about the subjective experiences of therapists and patients regarding the psychotherapy process and its results. Only few studies have attempted to integrate both perspectives, considering the influence of a patient’s characteristics and diagnosis in the construction of this experience. Aim: To identify aspects of psychotherapy that contribute to therapeutic change based on the experience of a patient and her therapist, and to construct an integrated comprehension of the change process of a patient with Borderline Personality Disorder. Method: A single case was used to carry out a qualitative analysis of follow-up interviews of the participants of a long-term psychotherapy. Two qualitative approaches were combined into a model entitled “Discovery-Oriented Biographical Analysis” to reconstruct an integrated narrative. Results: This method yielded an integrated narrative organized into four “chapters” that reflect the subjective construction of both the patient’s and the therapist’s experience of psychotherapy in terms of meaning. Discussion: The understanding of psychotherapy as a multilevel process, in which different themes occur and develop simultaneously, is discussed. From this perspective, psychotherapy can be characterized as a process that involves the recovery of trust in others through corrective emotional experiences and the construction of a shared implicit relational knowledge. Clinical or methodological significance of this article: Research on the subjective experiences of psychotherapy must consider both patient and therapist as privileged but always complementary witnesses of their interaction. In addition, it should be noted that the experience of studying this biographical reconstruction generates a space where research and practice converge. The analysis of participants’ narratives provides fascinating windows into their perceptions of psychotherapy and the process of change (Safran, 2013); here, the researcher is not merely a advantaged observer or a good summarizer: He/she has the chance to imbue the psychotherapy with a new meaning by connecting it with a common set of knowledge and a body of socially shared experience.
Le management et la mesure de la performance environnementale

Cette these se propose d'etudier la problematique de la mesure et du management de la performance environnementale au travers de quatre articles. Dans un premier temps, une etude descriptive et longitudinale des indicateurs mobilises par la litterature pour mesurer la performance environnementale met en evidence son aspect multidimensionnel. Par la suite, une meta-analyse de 52 etudes empiriques confirme la relation positive entre la performance environnementale et financiere et plus particulierement lorsqu'elle est mesuree par des indicateurs organisationnels. Puis, une analyse de contenu des rapports annuels de 2005 a 2010 des 55 plus grandes entreprises industrielles francaises souligne l'utilisation croissante de systemes de management environnemental pour gerer cette problematique environnementale. Pour finir, une etude de cas realisee au sein d'une entreprise dont la strategie environnementale est consideree comme proactive montre comment la performance environnementale est managee de maniere interactive et pas uniquement mesuree.
Neural Differences between Covert and Overt Attention Studied using EEG with Simultaneous Remote Eye Tracking

Research on neural mechanisms of attention has generally instructed subjects to direct attention covertly while maintaining a fixed gaze. This study combined simultaneous eye tracking and electroencephalogram (EEG) to measure neural attention responses during exogenous cueing in overt attention shifts (with saccadic eye movements to a target) and compared these with covert attention shifts (responding manually while maintaining central fixation). EEG analysis of the period preceding the saccade latency showed similar occipital response amplitudes for overt and covert shifts, although response latencies differed. However, a frontal positivity was greater during covert attention shifts, possibly reflecting saccade inhibition to maintain fixation. The results show that combined EEG and eye tracking can be successfully used to study natural overt shifts of attention (applicable to non-verbal infants) and that requiring inhibition of saccades can lead to additional frontal responses. Such data can be used to refine current neural models of attention that have been mainly based on covert shifts.
Keratocyte phenotype is enhanced in the absence of attachment to the substratum

Purpose Keratocytes, mesenchymal cells populating the corneal stroma, secrete the unique transparent connective tissue of the cornea as well as opaque scar tissue after injury. Previous studies identified factors mediating keratocyte phenotype in vitro, particularly the expression of the keratan sulfate proteoglycans, which are essential for vision. Whereas earlier work emphasized effects of cytokines, the current study examines the effects of substratum attachment on keratocyte phenotype. Methods Primary keratocytes from collagenase digestion of bovine corneas were cultured on tissue-culture plastic or on poly (2-hydroxyethylmethacrylate)(polyHEMA)-coated, non-adhesive surfaces. Secreted proteoglycans from culture media and cell-associated proteins were characterized using western blotting or isotopic labeling. Gene expression was characterized with quantitative reverse-transcriptase polymerase chain reaction (qRT–PCR). Secreted matrix was examined with immunostaining. Results We observed that virtually all primary keratocytes participate in the formation of spheroidal aggregates, remaining viable for at least four weeks in vitro. Spheroid keratocytes secrete more keratan sulfate and keratocan than attached cells in the same culture medium. In spheroids, keratocytes accumulate substantial matrix in intercellular spaces, including keratan sulfate, lumican, keratocan, and collagens V and VI. The unattached cells undergo limited cell division and do not differentiate into myofibroblasts in response to transforming growth factor β (TGFβ), which is based on the expression of extra domain A (EDA) fibronectin and α-smooth muscle actin. Similarly, the platelet derived growth factor, a cytokine initiating the fibroblastic phenotype in attached keratocytes, had a limited effect on the spheroid-associated keratocytes. Ascorbate-2-phosphate was the only agent stimulating keratan sulfate secretion in the spheroid keratocytes. Conclusions These results provide a new paradigm for understanding signals that regulate extracellular matrix secretion. For primary keratocytes, the alteration of the cellular environment in terms of cell-cell and cell-matrix interactions mediates and can override signals from soluble cytokines in influencing matrix expression and also in adopting other aspects of the fibroblastic and myofibroblastic phenotypes found in healing wounds.
Radioimmunoassay of inhibin: serum responses to unilateral and bilateral orchidectomy.

An overnight double antibody RIA using a rabbit antiserum to porcine inhibin alpha-chain [Tyr30] (1-30) NH2 [pI alpha(1-30)], radioiodinated pI alpha(1-30), and a preprecipitated second antibody complex has been developed to measure inhibin concentrations in sera and other biological fluids. The assay is accurate, precise (intraassay coefficient of variation, 4.8%), sensitive (25 pM; 2.5 fmol/tube), and specific for inhibin. The synthetic reference standard pI alpha(1-30) produced a displacement curve that paralleled intact male ovine and bovine sera, crude bovine follicular fluid, and a partially purified porcine follicular fluid reference preparation (WHO/NIH 86/690). Bilateral castration of prepubertal and postpubertal ram lambs resulted in a rapid decrease in serum inhibin concentrations and a subsequent increase in serum FSH. Inhibin levels were high in prepubertal lambs (approximately 375 pM), but these levels were not sustained near the time of puberty (approximately 180 pM). Intensive sampling by jugular venipuncture after castration indicated a 50% drop in circulating inhibin levels within 2 h of testes removal with chronic castrate levels (approximately 75 pM) achieved by 6 h postcastration. A rapid fall in circulating levels of inhibin was also observed after unilateral castration, but these values stabilized within hours to levels intermediate (i.e. approximately 200 pM) to those of intact and bilateral castrate rams. Hemicastrates exhibited a more subtle rise in serum FSH after testis removal, with FSH and inhibin levels of prepubertal hemicastrates returning to mature intact ram values by 15 weeks of age. Serum inhibin levels remained low and FSH levels high at 14 days in unilateral castrate postpubertal rams. Inhibin immunoreactivity increased abruptly in castrate ewes and rams injected iv with 5 ml bovine follicular fluid. Serum inhibin reached 300 pM immediately after bovine follicular fluid injection, and castrate FSH levels decreased 30% to a nadir 8 h later. These physiological findings provide support for the validity and utility of this inhibin RIA and further suggest that the Sertoli cells (not the germ cells) are the likely source of the FSH release-inhibiting factor from the testis.