Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Group Drumming on Social-Emotional Behavior in Low-Income Children

Low-income youth experience social-emotional problems linked to chronic stress that are exacerbated by lack of access to care. Drumming is a non-verbal, universal activity that builds upon a collectivistic aspect of diverse cultures and does not bear the stigma of therapy. A pretest-post-test non-equivalent control group design was used to assess the effects of 12 weeks of school counselor-led drumming on social-emotional behavior in two fifth-grade intervention classrooms versus two standard education control classrooms. The weekly intervention integrated rhythmic and group counseling activities to build skills, such as emotion management, focus and listening. The Teacher's Report Form was used to assess each of 101 participants (n = 54 experimental, n = 47 control, 90% Latino, 53.5% female, mean age 10.5 years, range 10–12 years). There was 100% retention. ANOVA testing showed that intervention classrooms improved significantly compared to the control group in broad-band scales (total problems (P < .01), internalizing problems (P < .02)), narrow-band syndrome scales (withdrawn/depression (P < .02), attention problems (P < .01), inattention subscale (P < .001)), Diagnostic and Statistical Manual of Mental Disorders-oriented scales (anxiety problems (P < .01), attention deficit/hyperactivity problems (P < .01), inattention subscale (P < .001), oppositional defiant problems (P < .03)), and other scales (post-traumatic stress problems (P < .01), sluggish cognitive tempo (P < .001)). Participation in group drumming led to significant improvements in multiple domains of social-emotional behavior. This sustainable intervention can foster positive youth development and increase student-counselor interaction. These findings underscore the potential value of the arts as a therapeutic tool.
Combined bronchoalveolar lavage and transbronchial lung biopsy: safety and yield in ventilated patients

The aim of this study was to evaluate the safety and diagnostic yield of bedside bronchoalveolar lavage (BAL) combined with fibrescopic transbronchial lung biopsy (TBLB) in determining the aetiology of pulmonary infiltrates in mechanically ventilated patients. The records of 38 mechanically ventilated patients who underwent BAL/TBLB to investigate unexplained pulmonary infiltrates were retrospectively reviewed. Patients were divided into two groups: immunocompetent (group 1: n=22; group 1a: n=11, late acute respiratory distress syndrome (ARDS); group 1b: n=11, no ARDS) and immunocompromised (group 2, n=16). The procedure allowed a diagnosis in 28 patients (74%), inducing therapeutic modification in 24 (63%) and confirmation of clinical diagnosis in four (11%). In groups 1a, 1b and 2, diagnosis was obtained in 11 out of 11 (fibroproliferation), seven out of 11 and 10 out of 16 patients, and therapy changed in 11 out of 11 (administration of steroids), six out of 11 and seven out of 16 patients, respectively. Pneumothorax occurred in nine patients (four of group 1a), bleeding in four (<35 mL), and transient hypotension in two. No fatalities were procedure-related. Combined bronchoalveolar lavage/transbronchial lung biopsy is of diagnostic and therapeutic value in mechanically ventilated patients with unexplained pulmonary infiltrates, excluding those with late acute respiratory distress syndrome. Although complications are to be expected, the benefits of the procedure appear to exceed the risks in patients in whom a histological diagnosis is deemed necessary.
A Novel Form of Rotavirus NSP2 and Phosphorylation-Dependent NSP2-NSP5 Interactions Are Associated with Viroplasm Assembly

ABSTRACT Rotavirus (RV) replication occurs in cytoplasmic inclusions called viroplasms whose formation requires the interactions of RV proteins NSP2 and NSP5; however, the specific role(s) of NSP2 in viroplasm assembly remains largely unknown. To study viroplasm formation in the context of infection, we characterized two new monoclonal antibodies (MAbs) specific for NSP2. These MAbs show high-affinity binding to NSP2 and differentially recognize distinct pools of NSP2 in RV-infected cells; a previously unrecognized cytoplasmically dispersed NSP2 (dNSP2) is detected by an N-terminal binding MAb, and previously known viroplasmic NSP2 (vNSP2) is detected by a C-terminal binding MAb. Kinetic experiments in RV-infected cells demonstrate that dNSP2 is associated with NSP5 in nascent viroplasms that lack vNSP2. As viroplasms mature, dNSP2 remains in viroplasms, and the amount of diffuse cytoplasmic dNSP2 increases. vNSP2 is detected in increasing amounts later in infection in the maturing viroplasm, suggesting a conversion of dNSP2 into vNSP2. Immunoprecipitation experiments and reciprocal Western blot analysis confirm that there are two different forms of NSP2 that assemble in complexes with NSP5, VP1, VP2, and tubulin. dNSP2 associates with hypophosphorylated NSP5 and acetylated tubulin, which is correlated with stabilized microtubules, while vNSP2 associates with hyperphosphorylated NSP5. Mass spectroscopy analysis of NSP2 complexes immunoprecipitated from RV-infected cell lysates show both forms of NSP2 are phosphorylated, with a greater proportion of vNSP2 being phosphorylated compared to dNSP2. Together, these data suggest that dNSP2 interacts with viral proteins, including hypophosphorylated NSP5, to initiate viroplasm formation, while viroplasm maturation includes phosphorylation of NSP5 and vNSP2.
Secure attachment, self-esteem, and optimism as predictors of positive body image in women

Secure Attachment, Self-esteem, and Optimism as Predictors of Positive Body Image in Women. (August 2008) Erin Leverenz Sandoval, B.A., Southwestern University; M.S., Texas A & M University Chair of Advisory Committee: Dr. Michael Duffy This correlational cross-sectional study investigated body image from a positive psychology viewpoint by examining variables that were predicted to contribute to positive body image in women and testing a model describing the relationships among the variables. Negative body image has been correlated with many psychological problems in the literature, but less research has examined positive body image. Some questions addressed include: Is there a relationship between secure attachment and positive body image? Do self-esteem and optimism act as intervening variables in the predicted relationship between secure attachment and positive body image? To address these questions, data from 97 women were used in a structural equation modeling (SEM) analysis. Some of the hypotheses were supported, although the overall model was not. Secure attachment was found to be positively correlated with and predictive of self-esteem and optimism as hypothesized and in line with previous findings. Also as hypothesized, self-esteem and optimism were found to be moderately correlated. Self-esteem and optimism were not significantly related to body image in the SEM analysis and therefore the overall proposed model was not supported. In this
The Contribution of FDI Flows to Domestic Investment in Capacity, and Vice Versa

This chapter provides an empirical analysis of interactions between FDI flows and domestic investment in capacity. As a motivation for the empirical analysis, I provide highlights of a new theory of FDI. The theory captures unique feature: hands-on management standards, that enable investors to react in real time to ongoing changes in the economic environment, which surrounds investors. Equipped with superior managerial skills, foreign direct investors are able to outbid portfolio investors for the top productivity firms in a domestic specialized industry, in which they have some comparative advantage in the source country. Consequently, FDI investors make investment in the domestic firm's capacity, which is both larger in size, and of higher " quality " (that is, in terms of rates of returns), than domestic investors, or foreign portfolio investors. Gains to the host country from FDI stem from the informational value of FDI, over and above the traditional capital-flow gains. The predictions of the theory are consistent with evidence from panel data: larger FDI coefficients in the domestic investment and output growth regressions relative to the portfolio equity flow and international loan coefficients, reflect a more significant role for FDI in the domestic investment process than other types of capital inflows. Likewise, domestic investment in
The Perceived Effectiveness of Persuasive Messages: Questions of Structure, Referent, and Bias

To gain a sense of the persuasive efficacy of a message prior to implementation of a campaign, researchers often gather judgments of perceived effectiveness (PE). At present, they do so without much knowledge of the conceptual meaning or empirical properties of PE. In the spirit of construct explication, we report a study intended to address a series of questions about PE. Using student (N = 155) and community samples (N = 100), we found the following: (a) PE is a two-dimensional judgment involving global evaluations of message impact and specific judgments of message attributes, but it may be reducible to a single second-order factor, (b) most individuals reported using more than one referent (i.e., person or group) when making PE judgments, but the choice of referents varies by message and judge, and (c) judgments of PE are biased upward as a function of the number of referents chosen. Suggestions are offered for enhancing the validity of PE judgments in formative campaign research.
Inhomogeneous broadening by nuclear spin fields: A new limit for optical transitions in solids.

Using a low-strain, isotopically pure crystal of YLiF 4 , we have measured extremely narrow inhomogeneous linewidths (as low as 40 MHz) for the optical transitions of Er 3+ impurities. Inhomogeneous broadening due to strains and other defects is so low that a new mechanism limits the inhomogeneous linewidth: local magnetic fields due to fluorine nuclear spins
Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy

Purpose: We previously showed that gene expression of synaptic vesicle protein 2A (SV2A), the binding site for the antiepileptic drug levetiracetam, is reduced during epileptogenesis in the rat. Since absence of SV2A has been associated with increased epileptogenicity, changes in expression of SV2A could have consequences for the progression of epilepsy. Therefore we investigated hippocampal SV2A protein expression of temporal lobe epilepsy (TLE) patients and in rats during epileptogenesis and in the chronic epileptic phase.
REGULARITY AND STABILITY OF EQUILIBRIA IN AN OVERLAPPING GENERATIONS GROWTH MODEL

In an exogenous-growth economy with overlapping generations, the Cobb–Douglas production, any positive life-cycle productivity, and time-separable constant elasticity of substitution (CES) utility, we analyze local stability of a balanced growth equilibrium (BGE) with respect to changes in consumption endowments, which could be interpreted as a transfer policy. We show that generically, in the space of parameters, equilibria around a BGE are locally unique and are locally differentiable functions of endowments, with derivatives given by kernels. Furthermore, those equilibria are stable in the sense that the effects of temporary changes decay exponentially toward ±∞.
Healing rates for challenging rotator cuff tears utilizing an acellular human dermal reinforcement graft

Purpose: This study presents a retrospective case series of the clinical and structural outcomes (1.5 T MRI) of arthroscopic rotator cuff repair with acellular human dermal graft reinforcement performed by a single surgeon in patients with large, massive, and previously repaired rotator cuff tears. Materials and Methods: Fourteen patients with mean anterior to posterior tear size 3.87 ± 0.99 cm (median 4 cm, range 2.5–6 cm) were enrolled in the study and were evaluated for structural integrity using a high-field (1.5 T) MRI at an average of 16.8 months after surgery. The Constant-Murley scores, the Flexilevel Scale of Shoulder Function (Flex SF), scapular plane abduction, and strength were analyzed. Results: MRI results showed that the rotator cuff repair was intact in 85.7% (12/14) of the patients studied. Two patients had a Sugaya Type IV recurrent tear (2 of 14; 14.3%), which were both less than 1 cm. The Constant score increased from a preoperative mean of 49.72 (range 13–74) to a postoperative mean of 81.07 (range 45–92) (P value = 0.009). Flexilevel Scale of Shoulder Function (Flex SF) Score normalized to a 100-point scale improved from a preoperative mean of 53.69 to a postoperative mean of 79.71 (P value = 0.003). The Pain Score improved from a preoperative mean of 7.73 to a postoperative mean of 13.57 (P value = 0.008). Scapular plane abduction improved from a preoperative mean of 113.64° to a postoperative mean of 166.43° (P value = 0.010). The strength subset score improved from a preoperative mean of 1.73 kg to a postoperative mean of 7.52 kg (P value = 0.006). Conclusions: This study presents a safe and effective technique that may help improve the healing rates of large, massive, and revision rotator cuff tears with the use of an acellular human dermal allograft. This technique demonstrated favorable structural healing rates and statistically improved functional outcomes in the near term. Level of Evidence: 4. Retrospective case series.
Responses of terrestrial ecosystems and carbon budgets to current and future environmental variability

We assess the significance of high-frequency variability of environmental parameters (sunlight, precipitation, temperature) for the structure and function of terrestrial ecosystems under current and future climate. We examine the influence of hourly, daily, and monthly variance using the Ecosystem Demography model version 2 in conjunction with the long-term record of carbon fluxes measured at Harvard Forest. We find that fluctuations of sunlight and precipitation are strongly and nonlinearly coupled to ecosystem function, with effects that accumulate through annual and decadal timescales. Increasing variability in sunlight and precipitation leads to lower rates of carbon sequestration and favors broad-leaved deciduous trees over conifers. Temperature variability has only minor impacts by comparison. We also find that projected changes in sunlight and precipitation variability have important implications for carbon storage and ecosystem structure and composition. Based on Intergovernmental Panel on Climate Change model estimates for changes in high-frequency meteorological variability over the next 100 years, we expect that terrestrial ecosystems will be affected by changes in variability almost as much as by changes in mean climate. We conclude that terrestrial ecosystems are highly sensitive to high-frequency meteorological variability, and that accurate knowledge of the statistics of this variability is essential for realistic predictions of ecosystem structure and functioning.
Therapeutic effects, tolerability and safety of a multi-strain probiotic in Iranian adults with irritable bowel syndrome and bloating.

BACKGROUND Irritable bowel syndrome (IBS) is a common disorder in Iran with challenging treatment. Although trials have suggested that probiotics alleviate the complaints of patients with minimal side effects, they have not been investigated in Iranian adults. METHODS In a randomized double-blind study, 108 eligible IBS patients (Rome III Criteria) aged 20 - 70 years who referred consecutively to a clinical center in Tehran with abdominal bloating from 2010 to 2012 received a combination probiotics or placebo twice daily for 4 weeks. The objective was to evaluate the efficacy and safety of a multi-strain probiotics combination. One week prior to and throughout the treatment, the participants recorded their abdominal symptoms on a daily basis, using visual analogue scale and reported satisfactory relief of general symptoms at the end of each week. Adverse events were evaluated by self-reporting and physical examination. Continuous variables were analyzed by independent t-test and chi-square was used for binomials. RESULTS The baseline characteristics were balanced (60% female, mean age 36.7 ± 11.5). A total of 97 (51 intervention, 46 control) completed the treatment. Intention to treat analysis was done on 108 allocated subjects. 85% of the probiotic group reported satisfactory relief of general symptoms compared with 47% in the control group (P < 0.01). A reduction in abdominal bloating and pain with probiotic was superior to placebo [-13.0 vs. -3.7 (P < 0.01), -8.2 vs. -2.1 (P = 0.02), respectively]. No severe adverse drug reaction was seen in either group. CONCLUSIONS A 4-week period of treatment with the combination probiotics twice daily was safe, well tolerated, and effective in our patients. Further investigation is recommended for other subgroups of IBS. Trial Registration: IRCT.ir IRCT2012071010230N1.
The Galvanic Skin Response Inhibition Threshold: A Preliminary Study with an Australian Sample*

Galvanic skin response (G.S.R.) inhibition thresholds, giving an index of barbiturate tolerance, were determined for 20 depressive and 10 normal subjects. Barbiturate tolerance was found to effectively differentiate neurotic from psychotic depressives, and both these groups from normal controls. Neurotic depressives generally exhibited high G.S. R. inhibition thresholds relative to normals, while psychotic depressives exhibited low thresholds relative to normals. These results are discussed in terms of previous research on the sedation threshold. The G.S. R. inhibition threshold was found in some groups, to be systematically influenced by manifest anxiety. However, neither depressive severity nor age influenced barbiturate tolerance. Some potential clinical and experimental uses of the G.S. R. inhibition threshold are discussed.
Effects of incisor extraction on jaw and tongue motor representations within face sensorimotor cortex of adult rats

Loss of teeth is associated with changes in somatosensory inputs and altered patterns of mastication, but it is unclear whether tooth loss is associated with changes in motor representations within face sensorimotor cortex of rats. We used intracortical microstimulation (ICMS) and recordings of cortically evoked muscle electromyographic (EMG) activities to test whether changes occur in the ICMS‐defined motor representations of the left and right jaw muscles [masseter, anterior digastric (LAD, RAD)] and tongue muscle [genioglossus (GG)] within the cytoarchitectonically defined face primary motor cortex (face‐M1) and adjacent face primary somatosensory cortex (face‐S1) 1 week following extraction of the right mandibular incisor in anesthetized (ketamine‐HCl) adult male Sprague‐Dawley rats. Under local and general anesthesia, an “extraction” group (n = 8) received mucoalveolar bone surgery and extraction of the mandibular right incisor. A “sham‐extraction” group (n = 6) received surgery with no extraction. A “naive” group (n = 6) had neither surgery nor extraction. Data were compared by using mixed‐model repeated‐measures ANOVA. Dental extraction was associated with a significantly increased number of sites within face‐M1 and face‐S1 from which ICMS evoked RAD EMG activities, a lateral shift of the RAD and LAD centers of gravity within face‐M1, shorter onset latencies of ICMS‐evoked GG activities within face‐M1 and face‐S1, and an increased number of sites within face‐M1 from which ICMS simultaneously evoked RAD and GG activities. Our novel findings suggest that dental extraction may be associated with significant neuroplastic changes within the rat's face‐M1 and adjacent face‐S1 that may be related to the animal's ability to adapt to the altered oral state. J. Comp. Neurol. 518:1030–1045, 2010. © 2009 Wiley‐Liss, Inc.
The Dermoscopic Features in Infantile Hemangioma

Abstract: Dermoscopy is useful for evaluating the precise vascular structure. We recently applied dermoscopy to infantile hemangiomas without proliferation and showed polymorphous vascular structures. We now demonstrate two typical dermoscopic figures of proliferative infantile hemangiomas. One was a superficial hemangioma which showed polymorphous vascular structure without obvious red linear vessels and red dilated vessels. The other was a thicker hemangioma with a deeper component. This hemangioma had polymorphous vascular structures with red linear and red dilated vessels. These observations indicates the usefulness of dermoscopy for subclassifying infantile hemangioma.
Rolling Rigid Objects

Simulating the dynamics of rigid bodies plays an important role in virtual reality applications such as virtual assembly planning and ergonomy studies but also in the (cid:12)eld of computer animation. In order to decrease the complexity of the object representations and to increase the accuracy of the simulation algorithms one goal is to deal with objects with curved surfaces directly instead of approximating them by polyhedra. One important aspect of the dynamic behaviour of objects with curved surfaces is the rolling process. In this paper we develop the dynamics equations that describe the rolling motion of arbitrarily shaped rigid objects that are in a one-or two-point contact with an arbitrary surface. As a method to keep track of the pairs of closest points we use techniques from di(cid:11)erential geometry.
Nanostructured CMOS Wireless Ultra-Wideband Label-Free PCR-Free DNA Analysis SoC

A fully integrated 54-channel wireless fast-scan cyclic voltammetry DNA analysis SoC is presented. The microsystem includes 546 3D nanostructured and 54 2D gold DNA sensing microelectrodes as well as 54 pH sensors. Each channel consists of a chopper-stabilized current conveyer with dynamic element matching. It is utilized as the amperometric readout circuit with a linear resolution from 8.6 pA to 350 nA. The on-chip programmable waveform generator provides a wide range of user-controlled rate and amplitude parameters with a maximum scan range of 1.2 V, and scan rate ranging between 0.1 mV/sec to 300 V/sec. A digital ultra-wideband transmitter based on a delay line architecture provides wireless data communication with data rates of up to 50 Mb/sec while consuming 400 μW. The 3 mm × 3 mm prototype fabricated in a 0.13 μm standard CMOS technology has been validated in prostate cancer synthetic DNA detection with 10 aM label-free PCR-free detection limit. Each channel occupies an area of only 0.06 mm2 and consumes 42 μW of power from a 1.2 V supply.
Quaternary structure of hemoglobin in solution

Many important proteins perform their physiological functions under allosteric control, whereby the binding of a ligand at a specific site influences the binding affinity at a different site. Allosteric regulation usually involves a switch in protein conformation upon ligand binding. The energies of the corresponding structures are comparable, and, therefore, the possibility that a structure determined by x-ray diffraction in the crystalline state is influenced by its intermolecular contacts, and thus differs from the solution structure, cannot be excluded. Here, we demonstrate that the quaternary structure of tetrameric human normal adult carbonmonoxy-hemoglobin can readily be determined in solution at near-physiological conditions of pH, ionic strength, and temperature by NMR measurement of 15N-1H residual dipolar couplings in weakly oriented samples. The structure is found to be a dynamic intermediate between two previously solved crystal structures, known as the R and R2 states. Exchange broadening at the subunit interface points to a rapid equilibrium between different structures that presumably include the crystallographically observed states.