Miracle-dz/UniFAR-FTUs huggingface dataset:
Characteristics of Women Who Have Had Cosmetic Breast Implants That Could Be Associated with Increased Suicide Risk: A Systematic Review, Proposing a Suicide Prevention Model

Literature indicates an increased risk of suicide among women who have had cosmetic breast implants. An explanatory model for this association has not been established. Some studies conclude that women with cosmetic breast implants demonstrate some characteristics that are associated with increased suicide risk while others support that the breast augmentation protects from suicide. A systematic review including data collection from January 1961 up to February 2014 was conducted. The results were incorporated to pre-existing suicide risk models of the general population. A modified suicide risk model was created for the female cosmetic augmentation mammaplasty candidate. A 2-3 times increased suicide risk among women that undergo cosmetic breast augmentation has been identified. Breast augmentation patients show some characteristics that are associated with increased suicide risk. The majority of women reported high postoperative satisfaction. Recent research indicates that the Autoimmune syndrome induced by adjuvants and fibromyalgia syndrome are associated with silicone implantation. A thorough surgical, medical and psycho-social (psychiatric, family, reproductive, and occupational) history should be included in the preoperative assessment of women seeking to undergo cosmetic breast augmentation. Breast augmentation surgery can stimulate a systematic stress response and increase the risk of suicide. Each risk factor of suicide has poor predictive value when considered independently and can result in prediction errors. A clinical management model has been proposed considering the overlapping risk factors of women that undergo cosmetic breast augmentation with suicide.
Multi-Fractal Spectral Analysis of the 1987 Stock Market Crash

The multifractal model of asset returns captures the volatility persistence of many financial time series. Its multifractal spectrum computed from wavelet modulus maxima lines provides the spectrum of irregularities in the distribution of market returns over time and thereby of the kind of uncertainty or randomness in a particular market. Changes in this multifractal spectrum display distinctive patterns around substantial market crashes or drawdowns. In other words, the kinds of singularities and the kinds of irregularity change in a distinct fashion in the periods immediately preceding and following major market drawdowns. This paper focuses on these identifiable multifractal spectral patterns surrounding the stock market crash of 1987. Although we are not able to find a uniquely identifiable irregularity pattern within the same market preceding different crashes at different times, we do find the same uniquely identifiable pattern in various stock markets experiencing the same crash at the same time. Moreover, our results suggest that all such crashes are preceded by a gradual increase in the weighted average of the values of the Lipschitz regularity exponents, under low dispersion of the multifractal spectrum. At a crash, this weighted average irregularity value drops to a much lower value, while the dispersion of the spectrum of Lipschitz exponents jumps up to a much higher level after the crash. Our most striking result, therefore, is that the multifractal spectra of stock market returns are not stationary. Also, while the stock market returns show a global Hurst exponent of slight persistence 0.5
Why Do Students Bully? An Analysis of Motives Behind Violence in Schools

Research on school bullying and violence has always been working with taxonomies of bullying to categorize aggressive acts. Researchers distinguish between direct and indirect or between physical, verbal, and relational bullying. Cyberbullying is categorized either by type of action or by type of medium. In this article, we propose another kind of categorization: the taxonomy of reasons. A questionnaire was developed that asks for the five dimensions “instrumental,” “power,” “sadism,” “ideology,” and “revenge. ” It was tested with middle-school children in Germany. While bullies claim that their reasons were mostly revenge, victims mostly insinuate sadism and power. Both groups claim that ideology and instrumental violence play a little role. Confirmatory Factor Analyses (CFA) show that at least four of the theoretically proposed dimensions make sense (except instrumentality). A qualitative analysis of open answers shows that for future questionnaires, the taxonomy should include additional dimensions, such as peer pressure and lack of self-control.
Inhibition of the Fc receptor-mediated oxidative burst in macrophages by the Yersinia pseudotuberculosis tyrosine phosphatase

Suppression of host-cell-mediated immunity is a hallmark feature of Yersinia pseudotuberculosis infection. To better understand this process, the interaction of Y. pseudotuberculosis with macrophages and the effect of the virulence plasmid-encoded Yersinia tyrosine phosphatase (YopH) on the oxidative burst was analyzed in a chemiluminescence assay. An oxidative burst was generated upon infection of macrophages with a plasmid-cured strain of Y. pseudotuberculosis opsonized with immunoglobulin G antibody. Infection with plasmid-containing Y. pseudotuberculosis inhibited the oxidative burst triggered by secondary infection with opsonized bacteria. The tyrosine phosphatase activity of YopH was necessary for this inhibition. These results indicate that YopH inhibits Fc receptor-mediated signal transduction in macrophages in a global fashion. In addition, bacterial protein synthesis was not required for macrophage inhibition, suggesting that YopH export and translocation are controlled at the posttranslational level.
International Entrepreneurial Orientation: Conceptual Considerations, Research Themes, Measurement Issues, and Future Research Directions

The amount of research conducted on the topic of international entrepreneurial orientation (IEO) has grown exponentially in recent years, thus inviting an analysis of the scholarly conversations taking place. This paper is a review and commentary on how the construct of entrepreneurial orientation (EO) has been leveraged within the international entrepreneurship literature. The possible distinctiveness of the EO and IEO constructs are considered, and the major themes of IEO research are summarized. Several measurement–related issues particularly pertinent to the assessment of EO as a generalizable/universalistic phenomenon are considered. The paper concludes with the identification of research foci whose pursuit promises to advance IEO knowledge along productive paths.
The self-adjusting file instrumentation results in less debris extrusion apically when compared to WaveOne and ProTaper NEXT

Aim: The present ex vivo study aimed to evaluate the debris extrusion after instrumenting the root canals by three different files systems. Materials and Methods: Sixty extracted human mandibular premolars with single canals were selected and randomly divided into three groups (n = 20) for instrumentation with three different files. Group 1: WaveOne (primary) single reciprocating file (WO; Dentsply Maillefer, Ballaigues, Switzerland) (25/08), Group 2: Self-adjusting file (SAF; ReDent-Nova, Ra’anana, Israel) (1.5 mm), and Group 3: ProTaper NEXT X1 and X2 (PTN; Dentsply Tulsa Dental, Tulsa, OK) (25/06). Debris extruding by instrumentation were collected into pre-weighed Eppendorf tubes. These tubes were then stored in an incubator at 70°C for 5 days. The tubes were then weighed to obtain the final weight, with the extruded debris. Statistical analysis for the debris extruded apically was performed using one-way analysis of variance and post hoc Tukey's test. Results: The statistical analysis showed a significant difference between all the three groups tested (P < 0.01). The following post hoc Tukey's test confirmed that Group 2 (SAF) exhibited significantly least (P < 0.01) debris extrusion between the three groups tested. Conclusions: The SAF resulted in significantly less extrusion of debris when compared to reciprocating WO and rotary PTN.
Psychological contract breach, organizational justice and emotional well-being

Purpose – Psychological contract breach, which represents instances when organizations fail to fulfil their side of the employment bargain, has been associated with salient concepts in strategic human resources management. The purpose of this paper is to investigate moderated mediated relationships involving breach, organizational (procedural and interactional) justice and emotional well-being. Design/methodology/approach – The study draws upon quantitative data collected by means of a questionnaire that was administered to 620 full-time technical and shop-floor employees in an automobile-parts company in Malta. The questionnaire included psychometrically validated scales on breach, justice and well-being. Findings – Breach partially mediated the relationship between justice and well-being while justice levels did not differentiate this mediating effect except for interactional justice. Finally, the interaction between procedural and interactional justice failed to explain the mediating role of breach ove.
A membrane-tethered transcription factor defines a branch of the heat stress response in Arabidopsis thaliana

In plants, heat stress responses are controlled by heat stress transcription factors that are conserved among all eukaryotes and can be constitutively expressed or induced by heat. Heat-inducible transcription factors that are distinct from the “classical” heat stress transcription factors have also been reported to contribute to heat tolerance. Here, we show that bZIP28, a gene encoding a putative membrane-tethered transcription factor, is up-regulated in response to heat and that a bZIP28 null mutant has a striking heat-sensitive phenotype. The heat-inducible expression of genes that encode BiP2, an endoplasmic reticulum (ER) chaperone, and HSP26.5-P, a small heat shock protein, is attenuated in the bZIP28 null mutant. An estradiol-inducible bZIP28 transgene induces a variety of heat and ER stress-inducible genes. Moreover, heat stress appears to induce the proteolytic release of the predicted transcription factor domain of bZIP28 from the ER membrane, thereby causing its redistribution to the nucleus. These findings indicate that bZIP28 is an essential component of a membrane-tethered transcription factor–based signaling pathway that contributes to heat tolerance.
Cytomegalovirus (CMV)-encoded UL144 (truncated tumor necrosis factor receptor) and outcome of congenital CMV infection.

BACKGROUND Cytomegalovirus (CMV) is the most common congenital infection in humans. The effect of viral strains on the outcome of congenital CMV is debated. We evaluated whether UL144 polymorphisms in amniotic fluid from CMV-infected Italian women were associated with terminations of pregnancy, subsequent disease in their offspring, or viral load. METHODS The study was nested within a prenatal CMV program. We sequenced the UL144 gene from 66 amniotic-fluid samples, without knowledge of pregnancy outcome. We performed data analyses on 56 samples for which all information was available. RESULTS Genotype C was associated with termination of pregnancy (P=.03). Genotype B was associated with fewer terminations of pregnancy (P=.003). A possible association was found between genotype C and symptomatic disease in newborns (odds ratio, 8.81 [95% confidence interval, 0.48-164.02]; P=.05). There was no association between specific genotype and the viral load in amniotic fluid. Symptomatic newborns who had the most common UL144 genotype (B) were more likely to have higher viral loads than were asymptomatic infants (P=.003). CONCLUSIONS UL144 polymorphisms may be associated with the outcome of congenital CMV infection. Larger studies should be conducted to confirm this association, before genotype analysis can be used, along with other factors, in considering terminations of pregnancy.
Modulating the metabolism by trimetazidine enhances myoblast differentiation and promotes myogenesis in cachectic tumor-bearing c26 mice

Trimetazidine (TMZ) is a metabolic reprogramming agent able to partially inhibit mitochondrial free fatty acid β-oxidation while enhancing glucose oxidation. Here we have found that the metabolic shift driven by TMZ enhances the myogenic potential of skeletal muscle progenitor cells leading to MyoD, Myogenin, Desmin and the slow isoforms of troponin C and I over-expression. Moreover, similarly to exercise, TMZ stimulates the phosphorylation of the AMP-activated protein kinase (AMPK) and up-regulates the peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC1α), both of which are known to enhance the mitochondrial biogenesis necessary for myoblast differentiation. TMZ also induces autophagy which is required during myoblast differentiation and promotes myoblast alignment which allows cell fusion and myofiber formation. Finally, we found that intraperitoneally administered TMZ (5mg/kg) is able to stimulate myogenesis in vivo both in a mice model of cancer cachexia (C26 mice) and upon cardiotoxin damage. Collectively, our work demonstrates that TMZ enhances myoblast differentiation and promotes myogenesis, which might contribute recovering stem cell blunted regenerative capacity and counteracting muscle wasting, thanks to the formation of new myofibers; TMZ is already in use in humans as an anti-anginal drug and its repositioning might impact significantly on aging and regeneration-impaired disorders, including cancer cachexia, as well as have implications in regenerative medicine.
Association of pharyngitis with oral antibiotic use for the treatment of acne: a cross-sectional and prospective cohort study.

OBJECTIVE To prospectively evaluate the association between antibiotics used to treat acne and pharyngitis. DESIGN Cross-sectional and 9-month prospective cohort. SETTING Urban university setting. PARTICIPANTS University students. INTERVENTION Participants were asked to fill out a survey form, were swabbed for culture, and had a visual examination for acne. MAIN OUTCOME MEASURE Report of pharyngitis. RESULTS In the cross-sectional study, 10 of the 15 students receiving oral antibiotics for acne reported an episode of pharyngitis in the previous 30 days, whereas 47 of the 130 students not receiving oral antibiotics, but who had acne, reported an episode of pharyngitis in the prior month. The unadjusted odds ratio (OR) (95% CI) associating current oral antibiotic use in acne patients with a self-reported episode of pharyngitis was 3.53 (95% CI, 1.14-10.95). In the cohort study, there were 358 female and 218 male participants; 36 (6.2%) received oral antibiotics for acne during the study, and 96 (16.6%) received topical antibiotics for acne. Using mixed model logistic regression, the OR was 4.34 (95% CI, 1.51-12.47) associating oral antibiotic use with pharyngitis. Less than 1% of participants were colonized by group A streptococcus, which was not associated with pharyngitis. CONCLUSIONS Our studies show that that the odds of reporting pharyngitis is more than 3 times baseline in patients receiving oral antibiotics for acne vs those who are not receiving oral antibiotics. The true clinical importance of these findings needs to be evaluated further by prospective studies, but this finding is not associated with group A streptococcus.
Towards aesthetics: a photo quality assessment and photo selection system

Automatic photo quality assessment and selection systems are helpful for managing the large mount of consumer photos. In this paper, we present such a system based on evaluating the aesthetic quality of consumer photos. The proposed system focuses on photos with faces, which constitute an important part of consumer photo albums. The system has three contributions: 1) We propose an aesthetics-based photo assessment algorithm, by considering different aesthetics-related factors, including the technical characteristics of the photo and the specific features related to faces; 2) Based on the aesthetic measurement, we propose a cropping-based photo editing algorithm, which differs from prior works by eliminating unimportant faces before optimizing photo composition; 3) We also incorporate the aesthetic evaluation with other metrics to select quintessential photos for a large collection of photos. The entire system is delivered by a web interface, which allows users to submit images or albums, and returns promising results for photo evaluation, editing recommendation, and photo selection.
Fractional flow reserve as the reference standard for myocardial perfusion studies: fool's gold?

The evidence for the use of cardiovascular magnetic resonance (CMR) as a first-line diagnostic tool in patients with suspected coronary artery disease (CAD) has been solidified by the recent publication of large clinical studies and meta-analyses.1–3 Most of this evidence has been gathered against anatomical angiographic endpoints, despite the well-known fact that luminal stenosis correlates poorly with haemodynamic significance, particularly for coronary stenoses between 30 and 80% of luminal diameter.4,5 Multiple factors, such as entrance effects, friction, and turbulence, can contribute to coronary blood flow resistance and the loss of pressure across a stenosis, and therefore the haemodynamic significance of lesions can be underappreciated by two-dimensional angiographic images, particularly in the setting of eccentric or irregular stenoses.6 In clinical practice, coronary angiography is therefore often complemented by non-invasive imaging tests to determine the functional significance of a borderline stenosis and guide patient management. Recent clinical practice guidelines for revascularization recommend a combination of anatomical and ischaemia testing for most clinical scenarios.7 Invasive pressure-wire-derived fractional flow reserve (FFR) has become a popular alternative for the functional assessment of coronary stenosis that can be performed in the catheter laboratory. FFR is calculated as the ratio of maximal blood flow in a stenotic artery relative to maximal flow in the same artery in the theoretic absence of any stenosis.8–11 In recent years, …
Compressive Properties of a Synthetic Bone Substitute for Vertebral Cancellous Bone

Transpedicular screw fixation in spinal fractures, degenerative changes, or deformities is a well-established procedure. However, important rate of fixation failure due to screw bending, loosening, or pullout are still reported particularly in weak bone stock in osteoporosis. To overcome the problem, mechanism of failure has to be fully investigated in vitro. Post-mortem human subjects are less accessible and animal cadavers comprise limitations due to different geometry and mechanical properties. Therefore, the development of a synthetic model mimicking the realistic human vertebra is highly demanded. A bone surrogate, composed of Polyurethane (PU) foam analogous to cancellous bone porous structure, was tested for 3 different densities in this study. The mechanical properties were investigated under uniaxial compression test by minimizing the end artifacts on specimens. The results indicated that PU foam of 0.32 g.cm density has comparable mechanical properties to human cancellous bone in terms of young’s modulus and yield strength. Therefore, the obtained information can be considered as primary step for developing a realistic cancellous bone of human vertebral body. Further evaluations are also recommended for other density groups. Keywords—Cancellous bone, Pedicle screw, Polyurethane foam, Synthetic bone
Credit Constraints, Job Mobility, and Entrepreneurship: Evidence from a Property Reform in China

Abstract This paper provides new evidence on the impact of private property rights and employer-provided housing on entrepreneurship. I find an increase in self-employment following a reform in urban China that allowed state employees who were renting state-owned housing the opportunity to buy their homes at subsidized prices. I develop a model of job choice to test two mechanisms that might explain how the reform increased entrepreneurship. I find evidence that the reform reduced labor mobility costs and alleviated credit constraints by allowing households to capitalize on the value of the real estate.
Individual Creativity and Group Ability to Utilize Individual Creative Resources: A Multilevel Model

The performance of 94 groups on 13 different open-ended tasks was studied. At the individual-team-member level, domain knowledge and performance-relevant behavioral measures of the three components of Amabile's (1983, 1996) theory of individual creativity related in predicted ways to individual differences. Support was found for new “cross-level” processes, labeled “team creativity-relevant processes. ” At the group level, these processes moderated the relationship between aggregated individual creativity and group creativity.
Collective bargaining in Germany: before 1933 and after 1945

COLLECTIVE BARGAINING HAS an old tradition in Germany, interrupted only by National Socialism. This method was developed through organizations of labor and employers ("Sozialpartner") rather than planned legislation. ' As early as 1873, printers' unions and the association of employers in the printing business agreed (1) that union men should be employed by members of the association only on the conditions stipulated by the two organized groups (Tarifvertrag),2 and that (2) members of unions should be given preference in employment. From the beginning German employers predominantly bargained on a multi-unit basis (regional or industry wide),' while labor bargained through craft unions combining people of similar skill and occupational background. Three unions competed in each field of occupation: the free (socialist) union, the Christian union, and the Hirsch Dunker (liberal) union.4 Therefore, it was necessary for associations of employers to bargain with each craft union operating in any field in which one of the member firms was interested. , Bargaining between associations was favored because the opinion prevailed that public interest can best be protected by collective action on both sides and the danger of exploitation of individuals excluded.6 The contents of all collective agreements may be divided into two principal parts: In Part I the two organizations made promises to each other, for ex-
Taste masking of diclofenac sodium using microencapsulation

This study addresses how to mask the undesirable taste of diclofenac sodium (DS) without interfering with an adequate rate of drug release. DS microcapsules were successfully prepared using a system of ethylcellulose (EC)- toluene - petroleum ether. The system was optimized by the construction of the phase diagram and determination of the amount of EC precipitated under different solvent:non-solvent ratios to determine the most appropriate conditions for preparing good microcapsules. Microcrystalline cellulose (Avicel) and lactose were mixed with DS powder and converted into spherical cores by the wet agglomeration technique which facilitated coacervation and formation of thin and uniform microcapsule walls. Diethylphthalate (DEP) and Polyethyleneglycol 600 (PEG) in different concentrations (20 or 40% w/w) were used as plasticizers to impart better elasticity to the microcapsules. The microcapsules were evaluated for DS released against crushed commercial DS enteric coated tablet (Voltaren). The prepared microcapsules were taste evaluated by a taste panel of 10 volunteers. The results revealed that the optimum solvent:non-solvent ratio required for microcapsule formation was 1:2. Microcapsules containing PEG 20% or DEP 40% showed a faster rate of DS release compared to that obtained from other microcapsules and crushed commercial enteric coated tablets (Voltaren). The palatability and the taste of DS were significantly improved by microencapsulation. The extent of taste masking was influenced by the microcapsule core:wall ratio, the presence of additives within the core, the type and concentration of plasticizer and initial core size.