Miracle-dz/UniFAR-FTUs huggingface dataset:
Pengaruh Persepsi Kegunaan, Persepsi Kemudahan, dan Keberhasilan Diri Atas Penggunaan Komputer Terhadap Minat Pemanfaatan Aplikasi SIMDA Keuangan (Studi Kasus pada Pemerintah Daerah Kabupaten Mojokerto)

Penelitian ini bertujuan untuk menguji faktor-faktor yang memengaruhi minat pemanfaatan aplikasi SIMDA Keuangan oleh pegawai di lingkup Pemerintah Daerah Kabupaten Mojokerto dengan menggunakan model kombinasi TAM dan Teori Kognitif Sosial yang dikembangkan oleh Li et al (2011). Penelitian ini berhasil membuktikan secara empiris bahwa minat pemanfaatan aplikasi SIMDA dipengaruhi oleh persepsi kegunaan dan persepsi kemudahan yang merupakan bagian dari model TAM serta dipengaruhi oleh keberhasilan diri atas penggunaan komputer yang merupakan bagian dari Teori Kognitif Sosial. Persepsi kegunaan memiliki pengaruh paling dominan terhadap minat pemanfaatan aplikasi SIMDA Keuangan karena pegawai merasa lebih cepat dan efektif dalam menyelesaikan pekerjaannya menggunakan aplikasi tersebut. Implikasi penelitian ini adalah mendukung Peraturan Pemerintah Nomor 56 Tahun 2005 yang mewajibkan pemerintah daerah untuk menyelenggarakan sistem informasikeuangan daerah yang baik di setiap daerah guna mendukung pengelolaan dan pelaporankeuangan yang baik sesuai Peraturan Pemerintah Nomor 60 Tahun 2008 pasal 2 ayat (1). Kata kunci: Technology Acceptance Model (TAM), teori kognitif sosial, persepsi kegunaan,persepsi kemudahan, keberhasilan atas penggunaan komputer, minat, SIMDA.
Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial

Abstract Background First- and second-generation smallpox vaccines are contraindicated in individuals infected with human immunodeficiency virus (HIV). A new smallpox vaccine is needed to protect this population in the context of biodefense preparedness. The focus of this study was to compare the safety and immunogenicity of a replication-deficient, highly attenuated smallpox vaccine modified vaccinia Ankara (MVA) in HIV-infected and healthy subjects. Methods An open-label, controlled Phase II trial was conducted at 36 centers in the United States and Puerto Rico for HIV-infected and healthy subjects. Subjects received 2 doses of MVA administered 4 weeks apart. Safety was evaluated by assessment of adverse events, focused physical exams, electrocardiogram recordings, and safety laboratories. Immune responses were assessed using enzyme-linked immunosorbent assay (ELISA) and a plaque reduction neutralization test (PRNT). Results Five hundred seventy-nine subjects were vaccinated at least once and had data available for analysis. Rates of ELISA seropositivity were comparably high in vaccinia-naive healthy and HIV-infected subjects, whereas PRNT seropositivity rates were higher in healthy compared with HIV-infected subjects. Modified vaccinia Ankara was safe and well tolerated with no adverse impact on viral load or CD4 counts. There were no cases of myo-/pericarditis reported. Conclusions Modified vaccinia Ankara was safe and immunogenic in subjects infected with HIV and represents a promising smallpox vaccine candidate for use in immunocompromised populations.
Parent-Child Physical and Pretense Play: Links to Children's Social Competence.

Connections were examined between parent-child pretense and physical play and children's (median age = 5 years) social competence. Children's emotion knowledge and self-efficacy were assessed as possible mediators linking parent-child play behavior and children's social competence. The pattern of associations observed suggest that mutually responsive parent-child interaction during both pretense and physical play is associated with children's social competence. In addition, parent child joint pretense play is linked to children's social competence. Children's emo tion knowledge was positively associated with children's social competence, whereas children's self-efficacy was negatively associated with social competence. Tests for mediation revealed that parent-child mutual compliance during play accounted for unique variance in children's peer competence, whereas children's emotion knowledge did not account for a significant portion of the variance.
Corynebacterium parvum and cyclophosphamide as combination treatment for a murine mammary adenocarcinoma.

Weekly i.p. injections of killed Corynebacterium parvum and of cyclophosphamide (given on different days) strongly inhibited growth of a transplantable murine mammary adenocarcinoma. A significant portion (40 to 80%) of animals could be made tumor free by means of combined therapy. No tumor-free survivors were obtained with C. parvum alone, and tumor-free mice were obtained with cyclophosphamide alone only at the expense of a high incidence of deaths due to drug toxicity. No evidence of tumor rejection immunity was detected in the tumor-free survivors from the combined treatment protocols, suggesting that this therapeutic regimen is not associated with tumor rejection immunity.
Peroxisome proliferator-activated receptor-γ ligands as investigational modulators of angiogenesis

PPAR-γ ligands constitute important insulin sensitizers that have already been approved for the treatment of human metabolic disorders. They also exert pleiotropic effects on cell proliferation and cancer and are now being explored in preclinical studies. Angiogenesis constitutes a multifaceted process that is implicated in tumor development and other benign disease states that are associated with diabetes. Recent data have further extended the crucial role of PPAR-γ ligands as potential angiogenesis modulators, in vitro and in vivo. This review summarizes the latest knowledge of the role of PPAR-γ ligands in angiogenesis that are related to both malignant and non-malignant disease states. Taking into careful consideration the data so far, PPAR-γ could be considered as a therapeutic target for diverse disease states in which excessive angiogenesis is implicated, including cancer and diabetes complications.
Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures

There is controversy concerning the diabetes impact on bone quality, notorious in type 2 diabetic postmenopausal women. One pointed cause might be uncontrolled glycemia. In this study, the effect of chronic hyperglycemia in bone turnover, morphology, and biomechanics was evaluated in female Wistar rats in the presence/absence of estrogens (ovariectomy). Animals (n = 28) were divided into sham, ovariectomized (OVX), hyperglycemic (streptozotocin 40 mg/kg, single-dose i.p.-STZ), and hyperglycemic-ovariectomized (STZ + OVX) animals. Blood biomarkers were estimated 60 days postovariectomy. Body weight, vertebral microarchitecture (L4-histomorphometry), femur biomechanical properties (bending tests), tibia ultrastructure (scanning electron microscopy), and femur and urinary calcium (atomic absorption) were also evaluated. The increased PINP/CTX ratio of hyperglycemic animals and the similar ratio between STZ + OVX and healthy animals contrasting with the lower ratio of OVX (in line with its histomorphometric data) suggest a tendency for improved bone formation in hyperglycemic-ovariectomized animals. The increased tibia medullar canal, which contrasts with the unaffected cortical thickness of both hyperglycemic groups while that of OVX decreased, was associated to the increased stiffness and strength of STZ + OVX bones compared to those of OVX, in line with the observed ultrastructure. Concluding, chronic hyperglycemia in ovariectomized female rats causes bone morphological changes that translate positively in the ultrastructure and mechanical properties of cortical bones.
Correlations in hot dense helium

Hot dense helium is studied with first-principle computer simulations. By combining path integral Monte Carlo and density functional molecular dynamics, a large temperature and density interval ranging from 1000 to 1 000 000 K and 0.4 to 5.4 g cm−3 becomes accessible to first-principle simulations and the changes in the structure of dense hot fluids can be investigated. The focus of this paper is on pair correlation functions between nuclei, between electrons, and between electrons and nuclei. The density and temperature dependence of these correlation functions is analyzed in order to describe the structure of the dense fluid helium at extreme conditions.
Parallelizing irregular algorithms: a pattern language

Outside of the high-performance computing domain, many applications are irregular in the sense that opportunities to exploit parallelism change throughout the computation, due to the use of complex, pointer-based data structures such as lists and graphs. However, the parallel programming community has relatively little experience in parallelizing irregular applications, and we presently lack a deep understanding of the structure of parallelism and locality in the algorithms that underlie these applications. In this context, irregular algorithms pose a challenging problem to current parallelization methods and techniques. In recent years, the Galois project has proposed an approach for parallelizing irregular algorithms and applications that is based on a small set of simple abstractions. In this paper, we describe the Galois approach by means of a pattern language for parallel programming, thereby highlighting the key features of this approach, and elucidating more generally the concurrency patterns in irregular algorithms.
Plasmacellular differentiation in extranodal marginal zone B cell lymphomas of the ocular adnexa: an analysis of the neoplastic plasma cell phenotype and its prognostic significance in 136 cases

Aim: To determine (a) the expression of plasma cell related antigens in extranodal marginal zone B cell lymphomas (EMZL) of the ocular adnexa; and (b) the prognostic value of plasmacellular differentiation in these tumours. Methods: A consecutive case series of 136 ocular adnexal EMZL obtained from three ocular pathology centres over 20 years was analysed retrospectively. An extensive immunohistochemical panel, including the plasma cell related antigens VS38c, CD38, CD138, multiple myeloma oncogene-1-protein (MUM1/IRF4), and CREB binding protein (CBP) was performed. EMZL were defined as “plasmacellular differentiated” on the basis of morphological features, evidence of cytoplasmic immunoglobulin, negativity for BSAP/PAX5, and expression of at least one of the investigated plasma cell related antigens. Controls included normal or hyperplastic lymphatic tissues. Detailed clinical data were collected for most patients, and compared with the results of immunohistochemistry. The end points considered for statistical analysis were development of local tumour recurrence, development of systemic disease, and lymphoma related death. Results: 57 (42%) of the 136 ocular adnexal EMZL showed a plasmacellular differentiation; 45 of these plasmacytoid cases were primary tumours. In contrast with most admixed normal plasma cells, which displayed co-expression of MUM1/IRF4, Vs38c, CD38, CD138, and CBP, the plasmacellular differentiated EMZL tumour cells demonstrated co-expression of all five plasma cell related antigens in only six of 57 (11%) plasmacellular differentiated ocular adnexal EMZL. The most commonly expressed plasma cell related antigen was MUM1/IRF4, immunoreactivity being seen in 56/57 (98%) plasmacellular differentiated EMZL examined. Although the association of plasmacellular differentiation in primary ocular adnexal EMZL and disseminated disease was statistically significant on univariate analysis (p = 0.042), this was weaker on multivariate analysis. Conclusion: Plasmacellular differentiated tumour cells in EMZL demonstrate an aberrant immune profile for plasma cell related antigens when compared with normal plasma cells. On multivariate analysis, plasmacellular differentiation in ocular adnexal EMZL was not significantly associated with local recurrence, the development of systemic disease, or with lymphoma related death.
Prevalence of latent, neuropathogenic equine herpesvirus-1 in the Thoroughbred broodmare population of central Kentucky.

REASON FOR PERFORMING STUDY An emerging problem of equine herpesvirus-1 (EHV-1) infection in horses in the USA is a high-mortality myeloencephalopathy that commonly occurs where large numbers of horses are stabled. EHV-1 isolates recovered from recent neurological outbreaks represent a mutant virus strain that possesses enhanced neuropathogenicity. A central question of EHV-1 myeloencephalopathy is the latency carriage rate for these mutants of EHV-1 in USA horse populations. OBJECTIVE To estimate the prevalence of neuropathogenic strains of EHV-1 as latent infections in the Thoroughbred broodmare population of central Kentucky. METHODS Submandibular lymph nodes (SMLN) were collected during post mortem examination of 132 Thoroughbred broodmares. Total DNA purified from SMLN tissue was tested for the presence of latent EHV-1 DNA by an ultrasensitive magnetic bead-based, sequence-capture, nested PCR method. Differentiation of active from latent infections by EHV-1 was achieved by detection of transcripts of EHV-1 glycoprotein B by reverse transcription PCR. RESULTS Latent EHV-1 DNA was detected in the SMLN tissues of 71 (54%) of the 132 mares submitted for necropsy. Thirteen (18%) of the 71 latently infected horses harboured the neuropathogenic biovar of EHV-1. Of the 13 horses latently infected with an ORF30 mutant strain of EHV-1, 11 also carried a latent, wild-type strain of the virus in their SMLN tissues. CONCLUSIONS Neuropathogenic strains of EHV-1 have established a significant presence in the Thoroughbred broodmare population of central Kentucky as latently infected carrier horses. The data also indicate that a highly sensitive DNA detection method is required to identify many instances of EHV-1 latency. POTENTIAL RELEVANCE The presence of a relatively large biological reservoir of latent, neuropathogenic EHV-1 has the potential for posing emerging equine health and economic threats to the future prosperity of the USA horse industry.
The Task of Integration: A Modest Proposal

This article examines the issue of integration and proposes a typology of four different kinds of integration: interdisciplinary, intradisciplinary, faith-praxis, and experiential integration. The elaboration of the nature of each type of integration includes specific implications for Christians. The proposal is intended to clarify the integration discussion and stimulate dialogue on these important issues.
RASSF1A Promoter Hypermethylation Is a Strong Biomarker of Poor Survival in Patients with Salivary Adenoid Cystic Carcinoma in a Chinese Population

In addition to the clinicopathological parameters, molecular biomarkers are becoming increasingly important in the prognostic evaluation of cancer patients. This study aimed to determine the molecular alterations in the RAS association domain family protein1A gene (RASSF1A) in salivary adenoid cystic carcinoma (ACC) and to evaluate the potential of such alterations as prognostic markers. One hundred and sixty-seven ACC tumor tissues and 50 samples of matched normal salivary gland tissues from the same patients were analyzed for RASSF1A promoter methylation status by bisulfite sequencing PCR (BSP) and/or methylation-specific PCR (MSP). Fifty ACC tumor tissues and matched normal salivary gland tissues were analyzed for loss of heterozygosity (LOH) by examining two microsatellite markers (D3S1478, D3S1621) at 3p21. RASSF1A gene mutations were detected by direct sequencing of all six exons in 50 tumor and normal tissue specimens. Over-all, RASSF1A promoter hypermethylation was detected in 35.3% (59/167) of ACC tissues and was associated with histologically solid tumor pattern (P = 0.002) and advanced TNM stage (P = 0.014). RASSF1A LOH was observed in 18.0% (9/50) of cases, and no somatic mutation of RASSF1A was detected in any cases. RASSF1A promoter methylation was associated with the poor over-all survival (Log-rank test, P <0.001) and disease-free survival (Log-rank test, P <0.001) and identified as an independent predicator of over-all patient survival (P = 0.009) and disease-free survival (P <0.001). It was concluded that RASSF1A methylation is involved in the development, differentiation and progression of ACC and is a strong independent biomarker of poor survival in ACC patients in a Chinese population.
The modality-switch effect: visually and aurally presented prime sentences activate our senses

Verifying different sensory modality properties for concepts results in a processing cost known as the modality-switch effect. It has been argued that this cognitive cost is the result of a perceptual simulation. This paper extends this argument and reports an experiment investigating whether the effect is the result of an activation of sensory information which can also be triggered by perceptual linguistically described stimuli. Participants were first exposed to a prime sentence describing a light or a sound’s perceptual property (e.g., “The light is flickering”, “The sound is echoing”), then required to perform a property-verification task on a target sentence (e.g., “Butter is yellowish”, “Leaves rustle”). The content modalities of the prime and target sentences could be compatible (i.e., in the same modality: e.g., visual–visual) or not (i.e., in different modalities). Crucially, we manipulated the stimuli’s presentation modality such that half of the participants was faced with written sentences while the other half was faced with aurally presented sentences. Results show a cost when two different modalities alternate, compared to when the same modality is repeated with both visual and aural stimuli presentations. This result supports the embodied and grounded cognition view which claims that conceptual knowledge is grounded into the perceptual system. Specifically, this evidence suggests that sensory modalities can be pre-activated through the simulation of either read or listened linguistic stimuli describing visual or acoustic perceptual properties.
Pharmacokinetic and pharmacodynamic evaluation of ramelteon: an insomnia therapy

Introduction: Ramelteon, a selective melatonin receptor agonist, is the first member of a novel class of hypnotics. It is approved for the treatment of insomnia characterized by sleep onset difficulties in the US and Japan, but not in Europe. Areas covered: The main clinical properties as well as safety issues of ramelteon are described. Relevant publications reporting ramelteon characteristics and its use in insomnia disorder were identified using PubMed and SciFinder databases up to January 2015. Additional information was collected from the US clinical trials database and from Takeda website. Expert opinion: Despite its high prevalence and economic burden, insomnia disorder remains mostly untreated. Ramelteon has demonstrated sleep-promoting effects in clinical trials and clinical practice, and it is not associated with the adverse effects typical of other class of hypnotics. Its efficacy appears to be relatively modest compared to current insomnia therapeutics, and its use seems restricted to patients with sleep onset difficulties. Assessment of ramelteon effects on sleep quality and maintenance, daytime function and of improvements in comorbid insomnia conditions deserves further studies. The potential application of ramelteon in other pathological conditions could open the way to novel therapeutic approaches as well as to new market opportunities.
Dilemmas of an Economic Theorist

The paper discusses four dilemmas encountered by an economic theorist. The dilemma of absurd conclusions: should we abandon a model if it produces absurd conclusions or should we regard a model as a very limited set of assumptions that will inevitably fail in some contexts? The dilemma of responding to evidence: should our models be judged according to experimental results? The dilemma of modelless regularities: should models provide the hypothesis for testing or are they simply exercises in logic that have no use in identifying regularities? The dilemma of relevance: do economists have the right to offer advice or to make statements that are intended to influence the real world?
Frequent Directions for Matrix Sketching with Provable Bounds: A Generalized Approach

ABSTRACT We consider the task of matrix sketching, which is obtaining a significantly smaller representation of matrix A while retaining most of its information (or in other words, approximates A well). In particular, we investigate a recent approach called Frequent Directions (FD) initially proposed by Liberty [5] in 2013, which has drawn wide attention due to its elegancy, nice theoretical guarantees and outstanding performance in practice. Two follow-up papers [3] and [2] in 2014 further refined the theoretical bounds as well as improved the practical performance. In this report, we summarize the three papers and propose a Generalized Frequent Directions (GFD) algorithm for matrix sketching, which captures all the previous FD algorithms as special cases without losing any of the theoretical bounds. Furthermore, we implemented our GFD algorithm and show experimental results on synthetic and real-world datasets from [2]. Specifically, we explored a class of GFD algorithms called Monotonic GFDs (mGFDs) and experimentally show that they have less approximation errors and are at least one order of magnitude faster than previous best algorithms. We will make the code and data publicly available to promote peer research.
Dosimetric comparison of Acuros™ BV with AAPM TG43 dose calculation formalism in breast interstitial high-dose-rate brachytherapy with the use of metal catheters

Purpose Radiotherapy for breast cancer includes different techniques and methods. The purpose of this study is to compare dosimetric calculations using TG-43 dose formalism and Varian Acuros™ BV (GBBS) dose calculation algorithm for interstitial implant of breast using metal catheters in high-dose-rate (HDR) brachytherapy, using 192Ir. Material and methods Twenty patients who were considered for breast conservative surgery (BCS), underwent lumpectomy and axillary dissection. These patients received perioperative interstitial HDR brachytherapy as upfront boost using rigid metal implants. Whole breast irradiation was delivered TG-43 after a gap of two weeks. Standard brachytherapy dose calculation was done by dosimetry. This does not take into account tissue heterogeneity, attenuation and scatter in the metal applicator, and effects of patient boundary. Acuros™ BV is a Grid Based Boltzmann Solver code (GBBS), which takes into consideration all the above, was used to compute dosimetry and the two systems were compared. Results Comparison of GBBS and TG-43 formalism on interstitial metal catheters shows difference in dose prescribed to CTV and other OARs. While the estimated dose to CTV was only marginally different with the two systems, there is a significant difference in estimated doses of starting from 4 to 53% in the mean value of all parameters analyzed. Conclusions TG-43 algorithm seems to significantly overestimate the dose to various volumes of interest; GBBS based dose calculation algorithm has impact on CTV, heart, ipsilateral lung, heart, contralateral breast, skin, and ribs of the ipsilateral breast side; the prescription changes occurred due to effect of metal catheters, inhomogeneities, and scatter conditions.