Miracle-dz/UniFAR-FTUs huggingface dataset:
Practice-Based Evidence for a Brief Time-Intensive Multi-Modal Therapy Guided by Group-Analytic Principles and Method

Group analysts are increasingly being called upon to provide effectiveness evidence, which may be critical to the development of group analysis as a therapeutic intervention in National Health Service provision of psychotherapies. This article describes a practice-based outcomes research initiative conducted in a time-limited group-analytic programme. The research was manageable and informative for profiling patients before therapy, recording benefits during therapy, and measuring outcomes at the end of the programme. Results suggest that the therapeutic programme is effective in terms of yielding decreased symptoms and improved mental health, but longer follow-up is needed to measure benefits in interpersonal functioning. The research was conducted by clinicians in collaboration with academic researchers and demonstrates the benefits of a positive clinician-researcher relationship. Carrying out the research has helped the clinicians to address the national agenda of evidence-based practice and accountability.
Effect of Oxygenation on Xylose Fermentation by Pichia stipitis

The effect of oxygen limitation on xylose fermentation by Pichia stipitis (CBS 6054) was investigated in continuous culture. The maximum specific ethanol productivity (0.20 g of ethanol g dry weight−1 h−1) and ethanol yield (0.48 g/g) was reached at an oxygen transfer rate below 1 mmol/liter per h. In the studied range of oxygenation, the xylose reductase (EC 1.1.1.21) and xylitol dehydrogenase (EC 1.1.1.9) activities were constant as well as the ratio between the NADPH and NADH activities of xylose reductase. No xylitol production was found. The pyruvate decarboxylase (EC 4.1.1.1) activity increased and the malate dehydrogenase (EC 1.1.1.37) activity decreased with decreasing oxygenation. With decreasing oxygenation, the intracellular intermediary metabolites sedoheptulose 7-phosphate, glucose 6-phosphate, fructose 1,6-diphosphate, and malate accumulated slightly while pyruvate decreased. The ratio of the xylose uptake rate under aerobic conditions, in contrast to that under anaerobic assay conditions, increased with increasing oxygenation in the culture. The results are discussed in relation to the energy level in the cell, the redox balance, and the mitochondrial function.
Using Choice with Game Play to Increase Language Skills and Interactive Behaviors in Children with Autism

Children with autism often exhibit significant language delays and extremely disruptive behaviors when confronted with task situations or other interactions in which they would rather not partake. The developmental literature suggests that language skills may be increased by engaging in play interactions, but children with autism are unlikely to engage in interactive toy and game play. Providing choice opportunities may increase responding and adaptive behaviors in children with autism. Therefore, this investigation was conducted to assess the effects of choice during language intervention on disruptive behavior, social play/ pragmatic behaviors, and language development. Participants exhibited problem behaviors, a lack of engagement in interactive play, and delayed acquisition of grammatical morphemes. Within a reversal (ABAB) design, Choice and No Choice conditions were compared in a naturalistic language intervention procedure using play. Results indicated that when choice is permitted during language intervention within a play context, disruptive behaviors are considerably reduced, and levels of appropriate social play/pragmatic skills increase, thereby reducing interventionist redirection. Moreover, the children participating in the study showed generalization of the targeted language structures only to their home environments following intervention in the choice condition. Findings and directions for future research are discussed with regard to the importance of providing choice for children with autism.
Single Nucleotide Polymorphisms of Gemcitabine Metabolic Genes and Pancreatic Cancer Survival and Drug Toxicity

Purpose: To show whether single nucleotide polymorphisms (SNP) of drug metabolic genes were associated with toxicity of 2′,2′-difluoro 2′-deoxycytidine (gemcitabine)–based chemoradiotherapy and overall survival (OS) of patients with pancreatic cancer. Experimental Design: We evaluated 17 SNPs of the CDA, dCK, DCTD, RRM1, hCNT1, hCNT2, hCNT3, and hENT1 genes in 154 patients with potentially resectable pancreatic adenocarcinoma who were enrolled in clinical trials at The University of Texas M.D. Anderson Cancer Center (Houston, TX) from February 1999 to January 2006, with follow-up until April 2009. Patients received neoadjuvant concurrent gemcitabine and radiation therapy with or without gemcitabine-cisplatin induction therapy. The association of genotypes with toxicity or OS was tested, respectively, by logistic regression and Cox regression analysis. Results: None of the 17 SNPs, individually, had a significant association with OS. A combined genotype effect of CDA A-76C, dCK C-1205T, DCTD T-47C, hCNT3 C-69T, hENT1 T-549C, and hENT1 C913T on OS was observed. Patients carrying 0 to 1 (n = 43), 2 to 3 (n = 77), or 4 to 6 (n = 30) variant alleles had median survival time of 31.5, 21.4, and 17.5 months, respectively. The hazard ratio of dying was 1.71 (95% confidence interval, 1.06-2.76) and 3.16 (95% confidence interval, 1.77-5.63) for patients carrying two to three or four to six at-risk genotypes (P = 0.028 and P < 0.001), respectively, after adjusting for clinical predictors. CDA C111T, dCK C-1205T, dCK A9846G, and hCNT3 A25G, individually and jointly, had a significant association with neutropenia toxicity. Conclusions: These observations suggest that polymorphic variations of drug metabolic genes were associated with toxicity of gemcitabine-based therapy and OS of patients with resectable pancreatic cancer. Clin Cancer Res; 16(1); 320–29
A Review of Relation Extraction

Many applications in information extraction, natural language understanding, information retrieval require an understanding of the semantic relations between entities. We present a comprehensive review of various aspects of the entity relation extraction task. Some of the most important supervised and semi-supervised classiﬁcation approaches to the relation extraction task are covered in sufﬁcient detail along with critical analyses. We also discuss extensions to higher-order relations. Evaluation methodologies for both supervised and semi-supervised meth-ods are described along with pointers to the commonly used performance evaluation datasets. Finally, we also give short descriptions of two important applications of relation extraction, namely question answering and biotext mining.
Differential expression of circular RNAs in human umbilical cord mesenchymal stem cells treated with icariin

Human umbilical cord mesenchymal stem cells (hUMSCs) belong to a multipotent stem cell population. Transplantation of icariin (ICA)-treated hUMSCs have better tissue repairing function in chronic liver injury. This study was to investigate whether the tissue-repairing effects and migration of hUMSCs after ICA treatment were regulated by circular RNAs (circRNAs). ICA was used to treat hUMSCs in vitro for 1 week and the expression profiles of circRNAs were generated using RNA sequencing. Differentially expressed circRNAs in hUMSCs after ICA intervention were screened. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis were carried out to predict the potential function of dysregulated circRNAs. There were 52 differentially expressed circRNAs (32 circRNAs up-regulated and 20 circRNAs down-regulated) with fold change ≥2.0 before and after ICA treatment. ADP-ribosylation factors were associated with the dysregulated circRNAs among Gene Ontology analysis. Kyoto Encyclopedia of Genes and Genomes analysis showed that only endocytosis pathway was associated with up-regulated circRNAs, whereas 4 pathways including homologous recombination, RNA transport, axon guidance, and proteoglycans in cancer were related to down-regulated circRNAs. Fifty-two differentially expressed circRNAs and 238 predicted microRNAs were included in circRNAs-microRNAs network. The mechanism of ICA inducing hUMSCs migration may be through regulating circRNAs expression which affects ADP-ribosylation factors protein signal pathways.
Semicircular canals in Anolis lizards: ecomorphological convergence and ecomorph affinities of fossil species

Anolis lizards are a model system for the study of adaptive radiation and convergent evolution. Greater Antillean anoles have repeatedly evolved six similar forms or ecomorphs: crown-giant, grass-bush, twig, trunk, trunk-crown, and trunk-ground. Members of each ecomorph category possess a specific set of morphological, ecological and behavioural characteristics which have been acquired convergently. Here we test whether the semicircular canal system – the organ of balance – is also convergent among ecomorphs, reflecting the shared sensory requirements of their ecological niches. As semicircular canal shape has been shown to reflect different locomotor strategies, we hypothesised that each Anolis ecomorph would have a unique canal morphology. Using 3D semilandmarks and geometric morphometrics, semicircular canal shape was characterised in 41 Anolis species from the Greater Antilles and the relationship between canal shape and ecomorph grouping, phylogenetic history, size, and perch characteristics was assessed. Further, canal morphology of modern species was used to predict the ecomorph affinity of five fossil anoles from the Miocene of the Dominican Republic. Our study recovered ecomorph as the single-most important covariate of canal morphology in modern taxa; although phylogenetic history and size also showed a small, yet significant correlation with shape. Surprisingly, perch characteristics were not found to be significant covariates of canal shape, even though they are important habitat variables. Using posterior probabilities, we found that the fossil anoles have different semicircular canals shapes to modern ecomorph groupings implying extinct anoles may have been interacting with their Miocene environment in different ways to modern Anolis species.
Networks of Intergovernmental Organizations and Convergence in Domestic Economic Policies

We studied three potential causal mechanisms through which network dynamics of intergovernmental organizations (IGO) might cause convergence in domestic economic policies. First, IGO networks facilitate policy learning by providing relevant information. Second, they encourage policy emulation by creating a sense of affinity among countries that are closely connected by IGO networks. Finally, some powerful IGOs ‘‘coerce’’ their member states to adopt certain policies. We used causal modeling to test the relationships between different types of IGOs (and the causal mechanisms to which they mostly correspond) and policy convergence. The findings demonstrate the important roles played by salient IGOs such as the WTO, the EU, and the OECD, with each of them having a strong converging effect on their member states’ domestic economic policies. More interestingly, we find that the cumulative effects of multiple layers of even the weakest types of IGOs have strong causal effects on states’ domestic policies. Indeed, the shared memberships in IGOs with economic functions and with the minimal level of institutional capacity are not only statistically associated with, but also have converging causal effects on, countries’ domestic policies. This supports the information-driven policy learning mechanism. The emulation mechanism in which IGO networks create a sense of affinity and therefore facilitate policy diffusion and convergence, on the other hand, is not supported by empirical analysis.
School effectiveness and student achievement, consistent across subjects? : evidence from Dutch elementary and secondary education

This article presents a comparison between elementary and secondary schools in the Netherlands with respect to the consistency of achievement scores across subjects both at the individual level and the school level. The analyses showed less consistency at the student level within schools. Although findings with respect to the school level were less conclusive, the consistency appeared to be lower in secondary education when controlling for prior achievement and curriculum track.
A Four-year Review of Delayed Initial Treatment of Patients with Congenital Talipes equinovarus in a General Hospital

Congenital Talipes Equinovarus (CTEV), or club foot, is a common congenital orthopaedic abnormality of the foot, which is easily diagnosed but difficult to treat perfectly. Controversy in terms of its etiology, classification and management continues to exist. Delayed initial treatment in patients with clubfoot has a strong correlation with a poor outcome. The purpose of this study was to review the factors that influence the outcome in patients who get delayed initial treatment at Hasan Sadikin General Hospital so that poor outcome can be prevented. We reviewed the medical records of 15 patients (23 feet) during the period from January 2009 to December 2013 and analysed various factors including gender, age at time of first treatment, type of disorder, the level of success of non-surgical therapy, parent education level, family income and accessibility to health care centre. CTEV was more common in girls in our patients who were in the 6–12 months age group. The most common type of CTEV was the flexible type. Treatment with serial casting produced good results in most patients. The majority of parents' educational level was junior high school and had 2–5 million/month income. The accessibility of patients to health care centre was difficult.
Student Engagement at a Large Suburban Community College: Gender and Race Differences

Previous research shows that there are individual differences in academic achievement associated with gender and race. Research also suggests that student engagement is an important determinant of student outcomes/achievement. The present study explored student engagement at an extra-large community college. It specifically investigated possible individual differences in student engagement and explored how it maps on to student achievement. As predicted, the results indicate that there are gender and race differences in student engagement—females show greater engagement than males, and African-American students show greater engagement than students of other races. The results are discussed in the context of student achievement as indicated by students’ self-reported GPAs.
A Multifrequency Passive Sensing Tag With On-Chip Temperature Sensor and Off-Chip Sensor Interface Using EPC HF and UHF RFID Technology

State-of-the-art passive RFID tags are limited in terms of functionality and operating range due to the limited power that can be converted from the electromagnetic field. This is why state-of-the-art wireless sensor systems are mostly battery-based if a high operating range is required. The proposed ultralow-power on-chip sensor unit and off-chip sensor interface which provides enough energy to supply various sensors with a power consumption up to the milliwatt range make it possible to remotely power the proposed RFID tag and use it as wireless sensor node. Equipping sensor nodes with RFID functionality not only enables identification and logistic applications but also an easy integration of the sensing tag into existing RFID systems. Exploiting the different characteristics of HF and UHF RFID systems, namely the large operating range in UHF and the high available power in HF, increases the flexibility and applicability of wireless sensor nodes. This paper presents a remotely powered multifrequency sensing tag according to the EPC HF and EPC Class 1 Gen 2 UHF standard developed in a 0.13-μm low-cost CMOS process. Input powers of -10.3 or -7.9 dBm at a frequency of 900 MHz are necessary to operate the sensing tag with activated on-chip sensor unit or off-chip sensor interface, respectively.
Instrumental Variables and GMM: Estimation and Testing

We discuss instrumental variables (IV) estimation in the broader context of the generalized method of moments (GMM), and describe an extended IV estimation routine that provides GMM estimates as well as additional diagnostic tests. Stand-alone test procedures for heteroskedasticity, overidentification, and endogeneity in the IV context are also described.
P53 expression in synchronous colorectal cancer.

OBJECTIVE We reviewed cases of primary colorectal adenocarcinoma to document synchronous colon and rectum adenocarcinoma (SCRC). METHODS In a retrospective setting, 764 cases underwent surgical resection for primary colorectal adenocarcinoma and referred to the Department of Surgical Pathology, Uludag University, Medical Faculty for diagnoses between 1997 and 2006, were reviewed. Tumor site, depth of invasion, coexistence of adenoma, distance between these multiple primary tumors, degree of p53 expression, and p53 expression pattern indicating polyclonal or monoclonal origins were noted in order to establish a possible effect on prognosis. RESULTS There were 28 cases with SCRC of colon and rectum. Nine cases were female, 19 cases were male (female to male ratio was 1:2). Most of the cases were within the 5th and the 6th decades. There were statistically significant relationships between p53 expression and differentiation status (p=0.001), and invasion depth (p=0.03). Forty of 62 colorectal carcinomas showed immunohistochemical positivity for p53. Six cases showed a discordant pattern of p53 mutation among individual lesions indicating polyclonal origin. CONCLUSION Synchronous colon and rectum adenocarcinoma is not rare. The incidence is 3.6% in our series. We believe that further studies with larger series are needed for p53 to prove useful in predicting prognosis of SCRCs and assessing the polyclonal origin of SCRC at a genetic level.
Numerical Investigation of Pressure Load over Spillway Chutes with Vertical Curvatures

For flow conduits with mild slope and considerably large vertical curvatures the hydrostatic distribution of the pressure may be used for design proposes. However, for the spillway chutes actual pressure load over the steep slope beds with small vertical curvatures may differ from the hydrostatic pressure values. The differences in pressure load on curved bed chutes are mainly because of the centrifugal forces. In present work a two dimensional Finite Volume flow solver, which utilizes the Volume of Fluid technique, is devised to investigate the division of the numerically computed pressure from the hydrostatic assumptions using some measurements for laboratory test cases reported in the literature.
A Modified Integrated Genetic Model for Risk Prediction in Younger Patients with Acute Myeloid Leukemia

Background Although cytogenetics-based prognostication systems are well described in acute myeloid leukemia (AML), overall survival (OS) remains highly variable within risk groups. An integrated genetic prognostic (IGP) model using cytogenetics plus mutations in nine genes was recently proposed for patients ≤60 years to improve classification. This model has not been validated in clinical practice. Methods and Findings We retrospectively studied 197 patients with newly diagnosed de novo AML. We compared OS curves among the mutational profiles defined by the IGP model. The IGP model assigned patients with intermediate cytogenetics as having favorable, intermediate or unfavorable mutational profiles. The IGP model reassigned 50 of 137 patients with intermediate cytogenetics to favorable or unfavorable mutational profiles. Median OS was 2.8 years among 14 patients with intermediate cytogenetics and favorable mutational profiles (mutant NPM1 and mutant IDH1 or IDH2) and 1.3 years among patients with intermediate mutational profiles. Among patients with intermediate cytogenetics labeled as having unfavorable mutational profiles, median OS was 0.8 years among 24 patients with FLT3-ITD positive AML and high-risk genetic changes (trisomy 8, TET2 and/or DNMT3A) and 1.7 years among 12 patients with FLT3-ITD negative AML and high-risk mutations (TET2, ASXL1 and/or PHF6). OS for patients with intermediate cytogenetics and favorable mutational profiles was similar to OS for patients with favorable cytogenetics (p = 0.697) and different from patients with intermediate cytogenetics and intermediate mutational profiles (p = 0.028). OS among patients with FLT3-ITD positive AML and high-risk genetic changes was similar to patients with unfavorable cytogenetics (p = 0.793) and different from patients with intermediate IGP profile (p = 0.022). Patients with FLT3-ITD negative AML and high-risk mutations, defined as ‘unfavorable’ in the IGP model, had OS similar to patients with intermediate IGP profile (p = 0.919). Conclusions The IGP model was not completely validated in our cohort. However, mutations in six out of the nine genes can be used to characterize survival (NPMI, IDH1, IDH2, FLT3-ITD, TET2, DNMT3A) and allow for more robust prognostication in the patients who are re-categorized by the IGP model. These mutations should be incorporated into clinical testing for younger patients outside of clinical trials, in order to guide therapy.
Motivational and neural systems of religion

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Pretending Not to See or Hear, Refusing to Signify: The Farce and Tragedy of Geocentric Public Affairs Scholarship

This article opens with an inventory of how popular culture passion plays are homologous to the stampeding disenfranchisement everywhere of working classes and the emasculation of professional codes of ethics under siege by neoliberal initiatives and gambits.The article then examines a recent example of contemporary,“deconstructive” scholarly analysis and inventory of presidential “Orwellian doublespeak. ” The preoccupation among contemporary critical scholarship with “discourse analysis” and language gambits is criticized for displacing interrogation of real-event anomalies, as with the porous account given by the 9/11 Commission for what happened that fateful day. The article concludes by explaining how critical scholarship consistently falls short of unmasking Master Signifiers.