Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of the System Specification on the Optimal Selection of Clocked Storage Elements

This paper represents a departure from the conventional methods of design and analysis of clocked storage elements that rely on minimizing a fixed energy-delay metric. Instead it establishes a systematic comparison in the energy-delay design space based on the parameters of the surrounding blocks. We define the composite energy-efficient characteristic over all storage element topologies and identify the most efficient storage element depending on its position on the composite characteristic relative to other topologies within a pipeline stage. Thus, we show that an optimal design could use a mixed variety of clocked storage elements (CSEs) depending on their placement in the pipeline and critical path. Since a well-designed system has hardware intensities balanced for a given cycle, a CSE choice will be made depending on the pipeline and path intensities. We show that a meaningful comparison can be carried out only by acknowledging that the optimal design and choice of the clocked storage elements depends heavily on the application, and by analyzing the energy and delay of the clocked storage elements in context of this application. The analysis in the energy-delay space allows us to understand some intuitive design choices in a quantitative way and to identify the optimal storage element topologies for an arbitrary system specification
Antiedematogenic Evaluation of Copaifera langsdorffii Leaves Hydroethanolic Extract and Its Major Compounds

Inflammatory disorders affect many people worldwide, and medicinal plants are used to ameliorate these health problems. This paper reports the antiedematogenic and analgesic evaluation of Copaifera langsdorffii Desf. leaves hydroethanolic extract (Cop) and two of its isolated compounds: quercetin-3-O-α-l-rhamnopyranosyl (quercitrin) and kaempferol-3-O-α-l-rhamnopyranosyl (afzelin). For that, the following experimental protocols were undertaken locomotor performance, writhing induced by acetic acid, antinociceptivity induced by formalin, hot plate latency, paw oedema induced by carrageenan and dextran, and cell migration induced by lipopolysaccharide (LPS), as well as the measurement of nitric oxide (NO), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 10 (IL-10) in macrophages. Neither the extract nor the isolated compounds displayed analgesic activity. The obtained results showed that C. langsdorffii extract possesses antiedematogenic properties acting on peripheral sites, whereas quercitrin and afzelin are not involved. Moreover, these properties are not associated with cell migration inhibition, TNF-α, IL-6, or IL-10 regulation.
American Journal of Epidemiology Original Contribution Overview of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) brought together 10 cohorts to conduct a prospective study of the association between vitamin D status, measured as serum concentrations of 25-hydroxyvitamin D (25(OH)D), and the development of 7 rarer cancer sites: endometrial, esophageal, gastric, kidney, non-Hodgkin lymphoma, ovarian, and pancreatic cancers. The cohorts come from 3 continents, with participants from a wide range of latitude who are racially diverse. Across each cancer site, there was no evidence of a protective association between higher concentrations of 25-hydroxyvitamin D (>75 nmol/L) and cancer outcome. An increased risk at very high levels (100 nmol/L) was noted for pancreatic cancer, confirming previous reports. The articles included in this issue detail the overall design and governance of the project, correlates of vitamin D status, and results from the cancer site-specific investigations. The Vitamin D Pooling Project realizes a major goal of consortium efforts, namely, to rigorously test hypotheses for rarer cancer outcomes that may not be adequately addressed in any one prospective cohort study. The results of this study have application for the planning and conduct of intervention trials, especially in determining potential risks. Adequate vitamin D concentrations are necessary for bone health and prevention of rickets. The widespread prevalence of low concentrations of vitamin D has triggered great clinical, research, and public health interest in determining the amount of vitamin D required for optimal health. The interest in vitamin D as a cancer preventive agent arises from its biologic role in proliferation and apoptosis along with the presence of vitamin D in most tissues. The main source of circulating vitamin D is conversion of 7-dehydrocholesterol in the skin to cholecalciferol (D 3) upon exposure to ultraviolet B radiation (1). Dietary sources, even with fortification of food, remain a minor contributor to vitamin D status. With the recognition of widespread prevalence of deficient or insufficient vitamin D concentrations, some have advocated increasing vitamin D through supplements. In May 2009, a committee was appointed by the Food and Nutrition Board, Institute of Medicine of the National Academies, to evaluate and update the dietary reference intake for vitamin D, as well as calcium (2). The Committee is charged with evaluating evidence of both the adequacy of current dietary vitamin D intake recommendations , including optimal dose and …
SALT observations of the chromospheric activity of transiting planet hosts: mass-loss and star–planet interactions

We measured the chromospheric activity of the four hot Jupiter hosts WASP-43, WASP-51/HAT-P-30, WASP-72 & WASP-103 to search for anomalous values caused by the close-in companions. The Mount Wilson Ca II H&K S -index was calculated for each star using observations taken with the Robert Stobie Spectrograph at the Southern African Large Telescope. The activity level of WASP-43 is anomalously high relative to its age and falls among the highest values of all known main sequence stars. We found marginal evidence that the activity of WASP-103 is also higher than expected from the system age. We suggest that for WASP-43 and WASP-103 star-planet interactions (SPI) may enhance the Ca II H&K core emission. The activity levels of WASP-51/HAT-P-30 and WASP-72 are anomalously low, with the latter falling below the basal envelope for both main sequence and evolved stars. This can be attributed to circumstellar absorption due to planetary mass loss, though absorption in the ISM may contribute. A quarter of known short period planet hosts exhibit anomalously low activity levels, including systems with hot Jupiters and low mass companions. Since SPI can elevate and absorption can suppress the observed chromospheric activity of stars with close-in planets, their Ca II H&K activity levels are an unreliable age indicator. Systems where the activity is depressed by absorption from planetary mass loss are key targets for examining planet compositions through transmission spectroscopy.
Genetic and physical map of plasmid NR1: comparison with other IncFII antibiotic resistance plasmids.

Plasmids are circular extrachromosomal genetic elements that are ubiquitous among the bacterial genera and are also found in some eucaryotic organisms (17, 39, 82, 95). Plasmids encode a number of specialized functions that are generally nonessential for their bacterial hosts. However, these plasmid-encoded functions provide their host cells with versatility and adaptability for growth and survival under a variety of conditions. Plasmids and the transposable elements that they often contain may also have played an integral role in the evolution of bacterial species by promoting the distribution and exchange of genetic information (5). The various plasmid-mediated functions include genetic transfer, bacteriocin production and resistance, production of and resistance to antibiotics, resistance to heavy metals and deoxyribonucleic acid (DNA) damaging agents, metabolism of carbohydrates and hydrocarbons, toxin production, virulence and colonization factors, hemolysin production, and tumorigenicity and nitrogen fixation in plants. In addition, plasmids encode genes and functions that make them capable of autonomous replication. In combination with their dispensable nature, this has made them attractive as model systems for the study of DNA replication and its coordination with cell growth and division. Recently, plasmids have also become indispensable components of the methods of modern molecular biology research. The three major classes of plasmids that have been characterized most extensively include plasmid F, colicinogenic (Col) plasmids, and drug resistance (R) plasmids (17, 39, 82, 95, 139). The F plasmid is the classic fertility factor that is capable of promoting its own transfer, the transfer of other plasmids, and the transfer of the host bacterial chromosome during bacterial conjugation. Col plasmids mediate the production of colicins, which are toxins that kill certain species of bacteria. Col plasmids also confer resistance to their bacterial hosts for the particular colicin that they specify. R
Lazy Occlusion Grid Culling

We present Lazy Occlusion Grid Culling, a new image-based occlusion culling technique for rendering of very large scenes which can be of general type. It is based on a low-resolution grid that is updated in a lazy manner and that allows fast decisions if an object is occluded or visible together with a hierarchical scene-representation to cull large parts of the scene at once. It is hardware-accelerateable and it works efficiently even on systems where pixel-based occlusion testing is implemented in software. Lazy Occlusion Grid Culling Heinrich Hey Robert F. Tobler Vienna University of Technology {hey,rft}@cg.tuwien. ac.at Abstract. We present Lazy Occlusion Grid Culling, a new image-based occlusion culling technique for rendering of very large scenes which can be of general type. It is based on a low-resolution grid that is updated in a lazy manner and that allows fast decisions if an object is occluded or visible together We present Lazy Occlusion Grid Culling, a new image-based occlusion culling technique for rendering of very large scenes which can be of general type. It is based on a low-resolution grid that is updated in a lazy manner and that allows fast decisions if an object is occluded or visible together with a hierarchical scene-representation to cull large parts of the scene at once. It is hardware-accelerateable and it works efficiently even on systems where pixel-based occlusion testing is implemented in software.
Quantification of the age-pigment lipofuscin in brains of known-age, pond-reared prawns Penaeus japonicus (Crustacea, decapoda).

A quantitative study of the lipofuscin content was carried out by image analysis in brains of known-age, pond-reared Penaeus japonicus (Crustacea, Decapoda) with the aim of assessing the applicability of the lipofuscin technique as an estimator of the physiological age in penaeids. With this purpose, three distinct measurements of lipofuscin levels (% area fraction, granule density and mean granule size) were recorded in ten sections of the olfactory lobe cell mass (OLCM) per animal. The image analysis was based on the autofluorescence emitted by the pigment, which accentuates the contrast between the lipofuscin granules and the background tissue. The concentration of lipofuscin increased significantly with age and was independent of sex. The relationship between age and lipofuscin concentration (area fraction and granule density) was best described by a seasonalized von Bertalanffy function, since the accumulation rate of the pigment dramatically slowed down in fall-winter, probably as a result of reduced seasonal metabolism. The present results confirm the potential of the lipofuscin method in the estimation of physiological age in penaeids and suggest that the application of this methodology can be useful in studies of age structure in wild populations and in the assessment of natural resources. J. Exp. Zool. 286:120-130, 2000.
Active Learning by Learning

Pool-based active learning is an important technique that helps reduce labeling efforts within a pool of unlabeled instances. Currently, most pool-based active learning strategies are constructed based on some human-designed philosophy; that is, they reflect what human beings assume to be “good labeling questions. ” However, while such human-designed philosophies can be useful on specific data sets, it is often difficult to establish the theoretical connection of those philosophies to the true learning performance of interest. In addition, given that a single human-designed philosophy is unlikely to work on all scenarios, choosing and blending those strategies under different scenarios is an important but challenging practical task. This paper tackles this task by letting the machines adaptively “learn” from the performance of a set of given strategies on a particular data set. More specifically, we design a learning algorithm that connects active learning with the well-known multi-armed bandit problem. Further, we postulate that, given an appropriate choice for the multi-armed bandit learner, it is possible to estimate the performance of different strategies on the fly. Extensive empirical studies of the resulting ALBL algorithm confirm that it performs better than state-of-the-art strategies and a leading blending algorithm for active learning, all of which are based on human-designed philosophy.
IL‐25 prevents and cures fulminant hepatitis in mice through a myeloid‐derived suppressor cell‐dependent mechanism

Fulminant hepatitis (FH) is a disease characterized by massive destruction of hepatocytes with severe impairment of liver function. The pathogenesis of FH is not fully understood, but hyperactivity of T cells and macrophages with excessive production of cytokines are important hallmarks of the condition. In this study, we investigated the role of interleukin (IL)−25 in FH. IL‐25 expression was evaluated in patients with FH and in livers of mice with FH induced by D‐galactosamine (D‐Gal) and lipopolysaccharide (LPS). Mice were treated with IL‐25 before D‐Gal/LPS‐induced FH and before or after concanavalin A (ConA)‐induced FH. Mononuclear cells were isolated from livers of mice treated with or without IL‐25 and analyzed for GR1+CD11b+ cells. CFSE‐labeled T cells were cocultured with GR1+CD11b+ cells and their proliferation was evaluated by flow cytometry. Mice were also treated with a depleting anti‐GR1 antibody before IL‐25 and D‐Gal/LPS administration. IL‐25 was constitutively expressed in mouse and human liver and down‐regulated during FH. IL‐25 prevented D‐Gal/LPS‐induced FH and this effect was associated with increased infiltration of the liver with cells coexpressing GR1 and CD11b. In vitro studies showed that GR1+CD11b+ cells isolated from mice given IL‐25 inhibited T‐cell proliferation. Consistently, in vivo depletion of GR1+ cells abrogated the protective effect of IL‐25 in experimental D‐Gal/LPS‐induced FH. IL‐25 was both preventive and therapeutic in ConA‐induced FH. Conclusions: IL‐25 expression is markedly reduced during human and experimental FH. IL‐25 promotes liver accumulation of GR1+CD11b+cells with immunoregulatory properties. (Hepatology 2013;58:1436–1450)
Wavelet analysis of shoreline change on the Outer Banks of North Carolina: An example of complexity in the marine sciences

The horizontal, shore-perpendicular change in shoreline position along the Outer Banks of North Carolina is found to be a self-affine signal. We measure shoreline change by determining the horizontal change in position of the 0.8-m contour sampled from shore-perpendicular profiles spaced at 20-m intervals along the coast. The profiles are obtained from two light detection and ranging surveys performed in September 1997 and September 1998. For six selected sections of coast, wavelet analysis of the shoreline change signal indicates the signal is self-affine with a scaling exponent that varies from 1.2 to 2.1. This self-affine behavior indicates that the shoreline change signal is nonstationary with long-range persistence. A stochastic diffusion model of sediment transport replicates the observed self-affine behavior observed south of Cape Hatteras (scaling exponent between 1.2 and 1.6) whereas a random walk model replicates the signal observed north of Cape Hatteras (scaling exponent ≈2.0). Because of the finite nature of the data set, there are limits in space and time to the power law behavior of the system. Characteristics of such systems can be described by upper-truncated power laws, which yield the upper limits of power law behavior. Applying an upper-truncated power law to the data for one section of coast, we find an upper limit of 7 km for the maximum continuous alongshore distance eroding or accreting. For the same section of coast, we find upper limits of 25 m for the maximum shore-perpendicular erosion and 11 m for the maximum shore-perpendicular accretion during the study period.
Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome

Chronic Fatigue Syndrome (CFS) is defined as greater than 6 months of persistent fatigue that is experienced physically and cognitively. The cognitive symptoms are generally thought to be a mild cognitive impairment, but individuals with CFS subjectively describe them as “brain fog. ” The impairment is not fully understood and often is described as slow thinking, difficulty focusing, confusion, lack of concentration, forgetfulness, or a haziness in thought processes. Causes of “brain fog” and mild cognitive impairment have been investigated. Possible physiological correlates may be due to the effects of chronic orthostatic intolerance (OI) in the form of the Postural Tachycardia Syndrome (POTS) and decreases in cerebral blood flow (CBF). In addition, fMRI studies suggest that individuals with CFS may require increased cortical and subcortical brain activation to complete difficult mental tasks. Furthermore, neurocognitive testing in CFS has demonstrated deficits in speed and efficiency of information processing, attention, concentration, and working memory. The cognitive impairments are then perceived as an exaggerated mental fatigue. As a whole, this is experienced by those with CFS as “brain fog” and may be viewed as the interaction of physiological, cognitive, and perceptual factors. Thus, the cognitive symptoms of CFS may be due to altered CBF activation and regulation that are exacerbated by a stressor, such as orthostasis or a difficult mental task, resulting in the decreased ability to readily process information, which is then perceived as fatiguing and experienced as “brain fog. ” Future research looks to further explore these interactions, how they produce cognitive impairments, and explain the perception of “brain fog” from a mechanistic standpoint.
THE TERMINOLOGY OF FOOD TEXTURE

The current interest in food texture terminology and previous attempts to develop a system of definitions are noted. A systematicand comprehensive glossary of food texture termsis presented as a basis for discussion with the objective of achieving in due course a generally-agreed terminology. "What's in a name? that which we call a rose By any other name would smell as sweet". "'When I use a word', Humpty Dumpty said in a rather scornful tone, 'it means just what I choose it to mean - neither more nor less"'.
Low physical activity and obesity: causes of chronic disease or simply predictors?

BACKGROUND AND PURPOSE Many studies have shown associations between risk of morbidity and mortality with both obesity and low physical activity (PA), but association does not imply causality. Moreover, there is an inverse relationship between PA and obesity; therefore, controlling for one of these factors when investigating the risk associated with the other is essential. The purpose of this review is to determine whether low PA and obesity actually cause metabolic dysfunction and chronic disease, especially type 2 diabetes (T2D), rather than simply operating as predictors or markers. METHODS The case for causality is strengthened if the following two conditions are satisfied: first, that significant associations between obesity or low PA and risk persist after controlling appropriately; and second, that the physiological mechanisms by which obesity or low PA may exert a causal effect are clearly established. The studies examined include those that have used cardiorespiratory (CR) fitness as a surrogate measure for PA, thus also providing evidence for low CR fitness as an independent risk factor in its own right. RESULTS AND CONCLUSIONS Low PA and poor CR fitness are independent predictors of mortality related to type 2 diabetes and chronic disease in general. Together with well-demonstrated mechanisms, there is strong evidence that low PA and low CR fitness are direct, independent causes of metabolic dysfunction and type 2 diabetes. Despite some reports to the contrary, there is evidence that both general and visceral obesity are predictors of mortality and morbidity after controlling for PA. However, in the absence of established mechanisms, evidence is insufficient to conclude that either general or visceral obesity is a direct, independent cause of metabolic dysfunction or type 2 diabetes.
Activator of G-Protein Signaling 3–Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection

Many intracellular pathogens cause disease by subverting macrophage innate immune defense mechanisms. Intracellular pathogens actively avoid delivery to or directly target lysosomes, the major intracellular degradative organelle. In this article, we demonstrate that activator of G-protein signaling 3 (AGS3), an LPS-inducible protein in macrophages, affects both lysosomal biogenesis and activity. AGS3 binds the Gi family of G proteins via its G-protein regulatory (GoLoco) motif, stabilizing the Gα subunit in its GDP-bound conformation. Elevated AGS3 levels in macrophages limited the activity of the mammalian target of rapamycin pathway, a sensor of cellular nutritional status. This triggered the nuclear translocation of transcription factor EB, a known activator of lysosomal gene transcription. In contrast, AGS3-deficient macrophages had increased mammalian target of rapamycin activity, reduced transcription factor EB activity, and a lower lysosomal mass. High levels of AGS3 in macrophages enhanced their resistance to infection by Burkholderia cenocepacia J2315, Mycobacterium tuberculosis, and methicillin-resistant Staphylococcus aureus, whereas AGS3-deficient macrophages were more susceptible. We conclude that LPS priming increases AGS3 levels, which enhances lysosomal function and increases the capacity of macrophages to eliminate intracellular pathogens.
Towards Conceptual Indexing of the Blogosphere through Wikipedia Topic Hierarchy

This paper studies the issue of conceptually indexing the blogosphere through the whole hierarchy of Wikipedia entries. About 300,000 Wikipedia entries are used for representing a hierarchy of topics. Based on the results of judging whether each blog feed is relevant to a given Wikipedia entry, this paper proposes how to judge whether there exist blog feeds to be linked from the given entry. In our experimental evaluation, we achieved over 90% precision in this task.