Miracle-dz/UniFAR-FTUs huggingface dataset:
The Atlantic Slave Trade: A Census.

Curtin combines modern research and statistical methods with his broad knowledge of the field to present the first book-length quantitative analysis of the Atlantic slave trade. Its basic evidence suggests revision of currently held opinions concerning the place of the slave trade in the economies of the Old World nations and their American colonies. Curtin s work will not only be the starting point for all future research on the slave trade and comparative slavery, but will become an indispensable reference for anyone interested in Afro-American studies. "Journal of American History" Curtin has produced a stimulating monograph, the product of immaculate scholarship, against which all past and future studies will have to be judged. "Journal of American Studies" Professor Curtin s new book is up to his customary standard of performance: within the limits he set for himself, The Atlantic Slave Trade could hardly be a better or more important book. "American Historical Review" "
Linking Socioeconomic Status to the Academic Achievement of Mexican American Youth Through Parent Involvement in Education

This study uses data from 1,609 Mexican American students and their parents who participated in the National Educational Longitudinal Study to examine (a) the influence of multiple socioeconomic components on youth’s academic achievement, and (b) whether these effects were mediated by parent involvement in education. Results show that the factor with the strongest direct relationship to youth’s test scores was maternal occupation, followed by family income. Maternal education level was also predictive of youth’s academic achievement, whereas fathers’ education and occupation were not predictive of academic achievement. Parent involvement in education mediated the influence of both family income and maternal education on youth’s academic achievement. Pathways between socioeconomic status, parent involvement, and youth’s academic achievement suggest that Mexican American parents’ abilities to invest economic, social, and human capital in their children’s education leads to higher academic achievement among youth. Further, it appears that mothers and fathers play distinct roles in these processes. The article discusses implications of study findings for future research and interventions to improve academic achievement among Mexican American youth.
Functions of Class V Myosins in Neurons*

This minireview focuses on recent studies implicating class V myosins in organelle and macromolecule transport within neurons. These studies reveal that class V myosins play important roles in a wide range of fundamental processes occurring within neurons, including the transport into dendritic spines of organelles that support synaptic plasticity, the establishment of neuronal shape, the specification of polarized cargo transport, and the subcellular localization of mRNA.
Evaluation of paxillin expression in patients with oral squamous cell carcinoma: An immunohistochemical study

Background: Oral squamous cell carcinoma (OSCC) is the tenth most common cancer in the world. The diagnosis of OSCC remains problematic, especially in advanced-stage tumors. Aims: The present study was conducted to understand the pattern of expression of paxillin in varying grades of carcinomas and also to ascertain whether its expression has an association with increasing grades. Methods: A total of ninety formalin-fixed paraffin-embedded tissues of OSCC were included in the study comprising thirty cases of each of well-differentiated squamous cell carcinomas, moderately differentiated squamous cell carcinomas (MDSCCs) and poorly differentiated squamous cell carcinomas (PDSCCs). The tissue sections were subjected to immunohistochemical staining of paxillin using super polymer-sensitive polymer 3,3’ diaminobenzidine detection kit. All the three groups were analyzed on various parameters including staining intensity, location and percentage of staining. SPSS 19.0 was used to analyze the data. Results: Paxillin stain positivity was observed in 95.5% of the cases. Predominant intense paxillin staining was demonstrated in 17 (56.6%) cases of well-differentiated squamous cell carcinoma, 28 (93.3%) cases of moderately differentiated squamous squamous cell carcinoma and 15 (50%) cases of PDSCC. A predominant cytoplasmic staining was observed in 21 (70%) cases of PDSCC and cytoplasmic plus membrane staining in 14 (46.6%) cases of MDSCC. Conclusion: The present study provides evidence that paxillin may be involved in the development and progression of OSCC. Thus, paxillin could be considered a useful biomarker for patient management and prognosis.
BRIEF REPORT Testing Prospective Memory: Does the Value of a Borrowed Item Help People Remember To Get It Back?

The relationship between the value of an item borrowed from a patient for a prospective memory task and the number of cues required by the patient for requesting its return was analyzed in 63 consecutive patients referred for clinical neuropsychological evaluation. The correlation was negligible (? = -.001). Number of cues needed was better predicted by score on the Mini-Mental State Exam (r = -.541, p < .001) than by subject's age, sex, or education, or the value of the item taken.
Dendritic morphologies of retinal ganglion cells projecting to the nucleus of the optic tract in the rabbit

Focal injections of Rhodamine‐latex microspheres or Fast Blue were made in the nucleus of the optic tract (NOT) of four rabbits. After survival times of 8–10 days, both dyes were retrogradely transported to medium to large sized ganglion cell somas in the retinas contralateral, but not ipsilateral, to the injected NOT. Most labelled cells were located in or near the visual streak, but a significant percentage were also found in the midperiphery of both the inferior and superior retina. One hundred fifteen labelled cells in four living supervised retinas were impaled under visual control and successfully injected with Lucifer Yellow. The dendritic arborizations of 60 of these were drawn from photographic montages for morphological identification and analysis. Nearly all the injected ganglion cells had large, relatively dense dendritic trees that stratified narrowly in the proximal inner plexiform layer. The dendritic field size and dendritic density of these cells varied with eccentricity, but at all eccentricities their anatomical characteristics closely resembled those of intracellularly stained On directionally selective ganglion cells. In three of the four experiments, a small percentage of ganglion cells were also labelled in the visual streak that had bistratified morphologies resembling those of On‐Off directionally selective ganglion cells.
G6PD deficiency and absence of α‐thalassemia increase the risk for cerebral vasculopathy in children with sickle cell anemia

The aim of this study was to test the association between hematological/genetic factors and cerebral vasculopathy in children with sickle cell anemia (SCA). A group with cerebral vasculopathy (VASC) was composed of children who had stroke (n = 6), silent infarct (n = 11), or an abnormal transcranial Doppler (n = 5). Eighty‐four patients had neither positive history of stroke or silent infarct, nor abnormal transcranial Doppler (NORM group). An intermediate group (COND; n = 15) was composed of SCA children with a conditional transcranial Doppler. Biological analyses were performed on samples obtained at steady state and before the beginning of any chronic treatment. The comparisons of the three groups demonstrated a protective effect of α‐thalassemia against cerebral vasculopathy through its effects on hemoglobin and reticulocyte levels. Moreover, we observed higher frequency of G6PD deficiency in the VASC group compared with the other groups. Our study confirms the key role of α‐thalassemia and G6PD status in the pathophysiology of cerebral vasculopathy in SCA children.
Ultrasonography is not reliable in diagnosing liver cirrhosis in clinical practice.

BACKGROUND The diagnosis of liver cirrhosis is important in the evaluation and management of patients. Liver biopsy is the gold standard but it is invasive. Ultrasonography is a non-invasive and useful modality in assessing the liver for certain conditions but its sensitivity and specificity in diagnosing cirrhosis is unknown locally. AIM To assess the accuracy of ultrasonography in diagnosing compensated liver cirrhosis in daily clinical practice outside the context of clinical trials. METHODS All the liver biopsies were identified from the Pathology Logbook retrospectively from January 1998 to March 2001. Only patients who had both liver biopsy and ultrasonography with no clinical evidence of cirrhosis were included. Patients with incomplete data, hepatoma or liver secondaries were excluded. Ultrasonographic diagnosis of cirrhosis was based on nodularity or irregularity of the liver surface, small liver size, coarse echotexture and increase attenuation by using the 3.5 to 5 MHz transducers. RESULTS A total of 151 liver biopsies were performed during this period. Eighty-eight patients who had both ultrasound and liver biopsy were analysed. Seventeen patients had ultrasonographic diagnosis of cirrhosis but only six cases were proven by a liver biopsy. On the other hand, 10/16 cases of biopsy-proven cirrhosis were "missed" by ultrasound. Thus, the sensitivity of ultrasonography in diagnosing cirrhosis was 37.5% and the specificity was 84.7%. The positive and negative predictive values were 35.3% and 85.9% respectively. CONCLUSION Low frequency ultrasonography is not a sensitive test for the diagnosis of liver cirrhosis in daily clinical practice.
[Non verbal communication abilities in severe traumatic brain injury].

OBJECTIVE Discursive abilities of severe brain injured patient are always impaired: loss of flexibility, lack of cohesion and coherence, often more elliptic. We know few about nonverbal competencies during discourse. The objective is to verify nonverbal abilities of these patients by pragmatic analysis. METHODS Four men were examined more than 7 years after severe traumatic brain injury. Nonverbal Prutting and Kirchner Pragmatic Protocol (1987) were done allowing to a qualitative and quantitative measurement of paralinguistic behaviour: prosody and quality of speech, facial expression, posture, gaze, gesture. Two conditions were recorded: dual (descriptive discourse) and group (conversational discourse). Associated impairments such as cognitive and dysexecutive functioning were also investigated. RESULTS/DISCUSSION Impoverishment (loss of ability) or impaired inadequacity was observed in all patients. Paralinguistic competences of conversational discourse was worse than descriptive one. Facial expression, gaze functioning, referential gesture were more often impaired. Maladjustment could be interpretated in reference with dysexecutive syndrome. CONCLUSION In spite of the lack of information about the range of normal pragmatic behaviour, it seems that brain injured patients have shown poor nonverbal abilities during discourse. Rehabilitation training of communication skills would integrate this fact in order to improve interactivity and social relationship.
Towards a “Sample-In, Answer-Out” Point-of-Care Platform for Nucleic Acid Extraction and Amplification: Using an HPV E6/E7 mRNA Model System

The paper presents the development of a “proof-of-principle” hands-free and self-contained diagnostic platform for detection of human papillomavirus (HPV) E6/E7 mRNA in clinical specimens. The automated platform performs chip-based sample preconcentration, nucleic acid extraction, amplification, and real-time fluorescent detection with minimal user interfacing. It consists of two modular prototypes, one for sample preparation and one for amplification and detection; however, a common interface is available to facilitate later integration into one single module. Nucleic acid extracts (n = 28) from cervical cytology specimens extracted on the sample preparation chip were tested using the PreTect HPV-Proofer and achieved an overall detection rate for HPV across all dilutions of 50%–85.7%. A subset of 6 clinical samples extracted on the sample preparation chip module was chosen for complete validation on the NASBA chip module. For 4 of the samples, a 100% amplification for HPV 16 or 33 was obtained at the 1 : 10 dilution for microfluidic channels that filled correctly. The modules of a “sample-in, answer-out” diagnostic platform have been demonstrated from clinical sample input through sample preparation, amplification and final detection.
Radiation‐Induced Meningioma: A Distinct Molecular Genetic Pattern?

Radiation-induced meningiomas arise after low-dose irradiation treatment of certain medical conditions and are recognized as clinically separate from sporadic meningioma. These tumors are often aggressive or malignant, they are likely to be multiple, and they have a high recurrence rate following treatment compared with sporadic meningiomas. To understand the molecular mechanism by which radiation-induced meningioma (RIM) arise, we compared genetic changes in 7 RIM and 8 sporadic meningioma (SM) samples. The presence of mutations in the 17 exons of the neurofibromatosis type 2 (NF2) gene, which has been shown to be inactivated in sporadic meningiomas, was analyzed in RIM and SM using single-strand conformation polymorphism (SSCP) and DNA sequencing. In contrast to SM, which showed NF2 mutations in 50% of specimens, no mutations were found in RIM. In addition, Western blot analysis of schwannomin/merlin protein, the NF2 gene product, demonstrated protein levels comparable to normal brain in 4/4 RIM tumor samples analyzed. Loss of heterozygosity (LOH) of genomic regions, which were reported for SM, was also analyzed in all cases of RIM using 22 polymorphic DNA markers. Allele losses were found on chromosomes 1p (4/7), 9p (2/7), 19q (2/7), 22q (2/7), and 18q (1/7). From these observations we conclude that unlike sporadic meningiomas, NF2 gene inactivation and chromosome 22q deletions are far less frequent in RIM, and their role in meningioma development following low dose irradiation is less significant. Other chromosomal lesions, especially loss of 1p, possibly induced by irradiation, may be more important in the development of these tumors.
Looking for a Possible Framework to Teach Contemporary Art in Primary School

Traditionally, the learning of arts in the Estonian primary school has meant completion of practical assignments given by the teacher. The new national curriculum for basic school adopted in 2010 sets out new requirements for art education where the emphasis, in addition to practical assignments, is on discussion and understanding of art. The teacher must introduce pupils to both art history and contemporary art. As a result, primary teachers would likely serve their pupils more effectively if they reconsidered their current understandings of art education and update their teaching correspondingly. The action research method seeks to answer the following question: how should one change the art education process in primary school so that in addition to practical activities pupils would have opportunities to talk about and understand contemporary art? The article discusses a framework for modernising art education in primary school. Research shows that primary school learners are open to innovation and thus discussion of contemporary art can become a natural part of primary school art classes. The balance between creating and responding is a key to planning the art education processes today.
Recovery from Cycling Exercise: Effects of Carbohydrate and Protein Beverages

The effects of different carbohydrate-protein (CHO + Pro) beverages were compared during recovery from cycling exercise. Twelve male cyclists (VO2peak: 65 ± 7 mL/kg/min) completed ~1 h of high-intensity intervals (EX1). Immediately and 120 min following EX1, subjects consumed one of three calorically-similar beverages (285–300 kcal) in a cross-over design: carbohydrate-only (CHO; 75 g per beverage), high-carbohydrate/low-protein (HCLP; 45 g CHO, 25 g Pro, 0.5 g fat), or low-carbohydrate/high-protein (LCHP; 8 g CHO, 55 g Pro, 4 g fat). After 4 h of recovery, subjects performed subsequent exercise (EX2; 20 min at 70% VO2peak + 20 km time-trial). Beverages were also consumed following EX2. Blood glucose levels (30 min after beverage ingestion) differed across all treatments (CHO > HCLP > LCHP; p < 0.05), and serum insulin was higher following CHO and HCLP ingestion versus LCHP. Peak quadriceps force, serum creatine kinase, muscle soreness, and fatigue/energy ratings measured pre- and post-exercise were not different between treatments. EX2 performance was not significantly different between CHO (48.5 ± 1.5 min), HCLP (48.8 ± 2.1 min) and LCHP (50.3 ± 2.7 min). Beverages containing similar caloric content but different proportions of carbohydrate/protein provided similar effects on muscle recovery and subsequent exercise performance in well-trained cyclists.
Presenilins and Calcium Signaling—Systems Biology to the Rescue

New results support function of presenilins as endoplasmic reticulum calcium leak channels. Mutations in presenilins result in familial Alzheimer’s disease (FAD). Presenilins encode a catalytic subunit of the γ-secretase complex, and FAD mutations in presenilins alter γ-secretase activity. Many FAD mutations in presenilins also affect intracellular calcium signaling. To explain these results, it was proposed that presenilins also function as endoplasmic reticulum (ER) calcium leak channels and that this function is disrupted by FAD mutations. Although this hypothesis has been controversial, new research supports the calcium leak channel hypothesis. One group reported the presence of putative ion-conduction pore in the high-resolution crystal structure of bacterial presenilin homolog PSH1. Another group identified an essential role for presenilins in mediating ER calcium leak in a cell-based screen for calcium homeostasis modulators. These results should enable the field to move forward and to focus on exploring connections between FAD mutations in presenilins, changes in γ-secretase and ER Ca2+ leak functions, and development of the disease.
Factors to Consider for Optimal Span of Control in Community Supervision Evidence-Based Practice Environments

In the face of budgetary constraints, legislative discussions in Iowa have focused on fiscal savings through an increased probation/parole supervisor to officer ratio, resulting in a reduced number of supervisory staff. Ramifications of this change, given the concurrent implementation of evidence-based practices (EBP), are unknown, given the lack of existing research on rubric for span of control decisions within community corrections agencies. Interviews with stakeholders in both Iowa and a national convenience sample led to a development of factors that should be considered in the future, including an agency’s level of task complexity, the workforce skill level, and the work environment, such as the dynamic nature of assigned tasks. Participants perceived high span of control ratios in a typical community corrections environment would challenge the initial implementation of an effective EBP approach. Policy and practical implications are discussed.
Response-Selection-Related Parietal Activation during Number Comparison

Neuroimaging studies of number comparison have consistently found activation in the intraparietal sulcus (IPS). Recently, it has been suggested that activations in the IPS vary with the distance between the numbers being compared. In number comparison, the smaller the distance between a number and the reference the longer the reaction time (RT). Activations in the right or left IPS, however, have also been related to attentional and intentional selection. It is possible, therefore, that activity in this region is a reflection of the more basic stimulus and response-selection processes associated with changes in RT. This fMRI experiment investigated the effect of numerical distance independently from RT. In addition, activations during number comparison of single-digit and double-digit stimuli were compared. During number comparison blocks, subjects had to indicate whether digits were greater or smaller than a reference (5 or 65). In control blocks, they were asked to perform a perceptual task (vertical line present/absent) on either numerical or nonnumerical stimuli. Number comparison versus rest yielded a large bilateral parietal-posterior frontal network. However, no areas showed more activation during number comparison than during the control tasks. Furthermore, no areas were more active during comparison of numbers separated by a small distance than comparisons of those separated by a large distance or vice versa. A left-lateralized parietal-posterior frontal network varied significantly with RT. Our findings suggest that magnitude and numerical-distance-related IPS activations might be difficult to separate from fundamental stimulus and response-selection processes associated with RT changes. As is the case with other parameters, such as space, magnitude may be represented in the context of response selection in the parietal cortex. In this respect, the representation of magnitude in the human IPS may be similar to the representation of magnitude in other nonhuman primates.