Miracle-dz/UniFAR-FTUs huggingface dataset:
Disruption factor of asphalt mixtures

Typically, aggregate gradation is selected to meet Superpave mix design specification; however, many Superpave mixtures have exhibited deficient field performance. The porosity of the dominant aggregate size range (DASR), which is the primary structural network of aggregates, has been extensively validated as a tool to evaluate coarse aggregate structure of laboratory and field asphalt mixtures. Mixtures identified by the system as having poor or marginal gradations resulted in poor rutting resistance. This study focused on how asphalt mixture performance is affected by changes in interstitial component (IC), which is the material between DASR particles. Laboratory testing clearly showed that IC characteristics may have a significant effect on rutting and cracking performance of mixtures. The disruption factor (DF) was developed to evaluate the potential of IC aggregates to disrupt the DASR structure. DF satisfactorily distinguished poor performing mixtures; therefore, it may eventually be used in combination with DASR porosity as a design parameter for rutting and cracking resistant asphalt mixtures.
Defining Seropositivity Thresholds for Use in Trachoma Elimination Studies

Background Efforts are underway to eliminate trachoma as a public health problem by 2020. Programmatic guidelines are based on clinical signs that correlate poorly with Chlamydia trachomatis (Ct) infection in post-treatment and low-endemicity settings. Age-specific seroprevalence of anti Ct Pgp3 antibodies has been proposed as an alternative indicator of the need for intervention. To standardise the use of these tools, it is necessary to develop an analytical approach that performs reproducibly both within and between studies. Methodology Dried blood spots were collected in 2014 from children aged 1–9 years in Laos (n = 952) and Uganda (n = 2700) and from people aged 1–90 years in The Gambia (n = 1868). Anti-Pgp3 antibodies were detected by ELISA. A number of visual and statistical analytical approaches for defining serological status were compared. Principal Findings Seroprevalence was estimated at 11.3% (Laos), 13.4% (Uganda) and 29.3% (The Gambia) by visual inspection of the inflection point. The expectation-maximisation algorithm estimated seroprevalence at 10.4% (Laos), 24.3% (Uganda) and 29.3% (The Gambia). Finite mixture model estimates were 15.6% (Laos), 17.1% (Uganda) and 26.2% (The Gambia). Receiver operating characteristic (ROC) curve analysis using a threshold calibrated against external reference specimens estimated the seroprevalence at 6.7% (Laos), 6.8% (Uganda) and 20.9% (The Gambia) when the threshold was set to optimise Youden’s J index. The ROC curve analysis was found to estimate seroprevalence at lower levels than estimates based on thresholds established using internal reference data. Thresholds defined using internal reference threshold methods did not vary substantially between population samples. Conclusions Internally calibrated approaches to threshold specification are reproducible and consistent and thus have advantages over methods that require external calibrators. We propose that future serological analyses in trachoma use a finite mixture model or expectation-maximisation algorithm as a means of setting the threshold for ELISA data. This will facilitate standardisation and harmonisation between studies and eliminate the need to establish and maintain a global calibration standard.
A Perceived Benefits and Barriers Scale for Strenuous Physical Activity in College Students

Purpose. Due to relatively low physical activity among college students, a standardized, reliable, and valid scale of perceived benefits and barriers for this population is critical. The purpose of this study was to develop a new scale, the Physical Activity Benefits and Barriers Scale, and determine whether the scale was appropriate for college students. Methods. An exploratory factor analysis of 26 benefit and 24 barrier items of physical activity was administered to 493 college students, followed by an examination of the relationship between the newly derived factors and physical activity, as well as test-retest reliability. Results. Twenty-eight items loaded on 10 factors that accounted for 60% of the variance, and 9 of the 10 factors were moderately associated with strenuous physical activity. Discussion. Psychometric properties were acceptable on this new scale, with the low motivation factor accounting for the highest amount of the variance in strenuous physical activity.
Effect of postoperative systemic therapy on pulmonary adenocarcinoma with unexpected pleural spread detected during thoracotomy or thoracoscopy

Background Occasionally, malignant pleural disease is only detected unexpectedly during surgery in patients with pulmonary adenocarcinoma. Previous studies mostly focused on the role of main tumor resection on patient's outcome, barely addressing the position of postoperative systemic therapy. Methods The medical records of 5321 non-small cell lung cancer patients who underwent thoracic surgery between January 1990 and December 2012 were reviewed. Pulmonary adenocarcinoma patients with unexpected pleural spread noted during surgery were included. The clinical and postoperative treatment variables were assessed for correlation with overall survival. Results In 134 patients identified, main tumor resection was performed in 87 (64.9%) patients, while 89 (66.4%) and 57 (42.5%) patients received postoperative chemotherapy and epidermal growth factor receptor- tyrosine kinase inhibitor (EGFR -TKI) therapy, respectively. Overall, the 5-year survival rate was 30.2% and median survival time was 29.3 months. Multivariate analysis showed main tumor resection and EGFR-TKI therapy were associated with better survival. Mutational status of EGFR was available in 57 patients and 43 (75.4%) had activating mutations. Resection of the main tumor conferred a better outcome in patients without EGFR mutation or with unknown EGFR mutation status and had not been treated with EGFR-TKI therapy (P = 0.003), but not in those with activating EGFR mutation and had been treated with EGFR-TKI (P = 0.857). Conclusions In pulmonary adenocarcinoma patients with unexpected pleural spread detected during surgery, main tumor resection and EGFR-TKI therapy correlated with better survival. Identifying EGFR mutation status before surgery can provide useful information for clinical decision during surgery.
Compositional chroma estimation using powered Euclidean distance

Chroma features are a popular tool in musical signal processing and information retrieval tasks, providing a compact representation of the tonal content of a piece of music. A variety of approaches to chroma estimation have been proposed, most of which rely on the summation of related frequency partials. However, frequency partials may be incorrectly assigned due to the log/linear relationship of frequency and pitch. Variations of chroma employing overtone suppression strategies are found in the literature. We propose a compositional model of chroma, which considers a coarse modelling of the effects of overtones in the expected chroma vectors of single notes. Synthetic chord recognition experiments indicate the usefulness of the proposed approach.
A genome-wide association study of corneal astigmatism: The CREAM Consortium

Purpose To identify genes and genetic markers associated with corneal astigmatism. Methods A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) and 8 Asian ancestry (n=9,120) cohorts was performed by the Consortium for Refractive Error and Myopia. Cases were defined as having >0.75 diopters of corneal astigmatism. Subsequent gene-based and gene-set analyses of the meta-analyzed results of European ancestry cohorts were performed using VEGAS2 and MAGMA software. Additionally, estimates of single nucleotide polymorphism (SNP)-based heritability for corneal and refractive astigmatism and the spherical equivalent were calculated for Europeans using LD score regression. Results The meta-analysis of all cohorts identified a genome-wide significant locus near the platelet-derived growth factor receptor alpha (PDGFRA) gene: top SNP: rs7673984, odds ratio=1.12 (95% CI:1.08–1.16), p=5.55×10−9. No other genome-wide significant loci were identified in the combined analysis or European/Asian ancestry-specific analyses. Gene-based analysis identified three novel candidate genes for corneal astigmatism in Europeans—claudin-7 (CLDN7), acid phosphatase 2, lysosomal (ACP2), and TNF alpha-induced protein 8 like 3 (TNFAIP8L3). Conclusions In addition to replicating a previously identified genome-wide significant locus for corneal astigmatism near the PDGFRA gene, gene-based analysis identified three novel candidate genes, CLDN7, ACP2, and TNFAIP8L3, that warrant further investigation to understand their role in the pathogenesis of corneal astigmatism. The much lower number of genetic variants and genes demonstrating an association with corneal astigmatism compared to published spherical equivalent GWAS analyses suggest a greater influence of rare genetic variants, non-additive genetic effects, or environmental factors in the development of astigmatism.
Effects of liver cirrhosis on portal vein embolization prior to right hepatectomy in patients with primary liver cancer

Preoperative portal vein embolization (PVE) induces compensatory hyperplasia of the future liver remnants (FLR), thus increasing resectability in the non-cirrhotic patients with primary liver cancer (PLC). However, it is unclear if it is similar in patients with liver cirrhosis. Therefore, the present study investigated the PVE value prior to liver resection in patients with PLC, and the liver cirrhotic effects on the compensatory hypertrophy of FLRs following PVE. In the present study, 21 patients with PLC who successfully underwent hepatic resection subsequent to PVE, were retrospectively examined. The patients were divided into a non-cirrhosis group and a cirrhosis group according to the absence or presence of cirrhosis, respectively. The FLR volume between the two groups of patients was compared. There was a significant difference in the FLR volume for all patients prior to, and 4–6 weeks following, PVE (P<0.001). PVE induced significant compensatory hypertrophy in the FLRs whether in the non-cirrhosis group (P=0.002) or cirrhosis group (P<0.001). However, no significant difference was identified between the two groups with respect to FLR volume enlargement 4–6 weeks following PVE (P=0.373). In conclusion, PVE prior to hepatectomy may promote FLR compensatory hypertrophy and an increase in the resectability of PLC tumors. No significant effects of liver cirrhosis were identified on liver lobe hyperplasia following PVE.
Association of 4-hydroxynonenal with classical adipokines and insulin resistance in a Chinese non-diabetic obese population.

BACKGROUND The prevalence of obesity is increasing worldwide. Oxidative stress plays an etiological role in a variety of obesity-related metabolic disorders. 4-hydroxynonenal (4-HNE) is the most abundant and reactive aldehydic product derived from the peroxidation of n-6 polyunsaturated fatty acids with diverse biological effects that are not well detailed. Obesity is associated with decreased plasma adiponectin concentrations and increased production of lipid peroxidation products, including 4-HNE, in adipose tissue. There may be some association between the level of adipokines and 4-HNE. MATERIAL AND METHODS To analyze the associations between 4-HNE and classical adipokines, namely, adiponectin and leptin in a Chinese population, the plasma 4-HNE, adiponectin and leptin levels of 160 non-diabetic obese (NDO) patients and 160 healthy subjects were determined by ELISA, and their associations with adiposity, glucose, lipid profiles, insulin secretion and insulin sensitivity were studied. RESULTS Plasma 4-HNE levels were significantly increased in patients with NDO compared with healthy controls (p < 0.01). 4-HNE was negatively correlated with adiponectin and positively correlated with leptin. The plasma levels of 4-HNE were significantly correlated to several parameters involved in body mass index (BMI) and insulin resistance (IR). The 4-HNE levels were positively correlated with BMI and negatively correlated with insulin sensitivity. CONCLUSION We conclude that 4-HNE is associated with the secretion of adiponectin and leptin and is correlated with IR in NDO humans. These findings indicate a pro-inflammatory role of 4-HNE in NDO patients, which supports the potential role of 4-HNE in the development of obesity-related disorders.
Probing changes of dust properties along a chain of solar-type prestellar and protostellar cores in Taurus with NIKA

The characterization of dust properties in the interstellar medium (ISM) is key for star formation. Mass estimates are crucial to determine gravitational collapse conditions for the birth of new stellar objects in molecular clouds. However, most of these estimates rely on dust models that need further observational constraints from clouds to prestellar and protostellar cores. We present results of a study of dust emissivity changes based on mm-continuum data obtained with the NIKA camera at the IRAM-30m telescope. Observing dust emission at 1.15 mm and 2 mm allows us to constrain the dust emissivity index ($\beta$) in the Rayleigh-Jeans tail of the dust spectral energy distribution (SED) far from its peak emission, where the contribution of other parameters (i.e. dust temperature) is important. Focusing on the Taurus molecular cloud, a low-mass star-forming regions in the Gould Belt, we analyze the emission properties of several distinct objects in the B213 filament: three prestellar cores, two Class-0/I protostellar cores and one Class-II object. By means of the ratio of the two NIKA channel-maps, we show that in the Rayleigh-Jeans approximation the dust emissivity index varies among the objects. For one prestellar and two protostellar cores, we produce a robust study using Herschel data to constrain the dust temperature of the sources. By using the Abel transform inversion technique we get accurate radial $\beta$ profiles. We find systematic spatial variations of $\beta$ in the protostellar cores that is not observed in the prestellar core. While in the former case $\beta$ decreases toward the center, in the latter it remains constant. Moreover, $\beta$ appears anticorrelated with the dust temperature. We discuss the implication of these results in terms of dust grain evolution between pre- and protostellar cores.
Arsenic Exposure from Drinking Water and Urinary Metabolomics: Associations and Long-Term Reproducibility in Bangladesh Adults

Background: Chronic exposure to inorganic arsenic from drinking water has been associated with a host of cancer and noncancer diseases. The application of metabolomics in epidemiologic studies may allow researchers to identify biomarkers associated with arsenic exposure and its health effects. Objective: Our goal was to evaluate the long-term reproducibility of urinary metabolites and associations between reproducible metabolites and arsenic exposure. Methods: We studied samples and data from 112 nonsmoking participants (58 men and 54 women) who were free of any major chronic diseases and who were enrolled in the Health Effects of Arsenic Longitudinal Study (HEALS), a large prospective cohort study in Bangladesh. Using a global gas chromatography–mass spectrometry platform, we measured metabolites in their urine samples, which were collected at baseline and again 2 y apart, and estimated intraclass correlation coefficients (ICCs). Linear regression was used to assess the association between arsenic exposure at baseline and metabolite levels in baseline urine samples. Results: We identified 2,519 molecular features that were present in all 224 urine samples from the 112 participants, of which 301 had an ICC of ≥0.60. Of the 301 molecular features, water arsenic was significantly related to 31 molecular features and urinary arsenic was significantly related to 74 molecular features after adjusting for multiple comparisons. Six metabolites with a confirmed identity were identified from the 82 molecular features that were significantly associated with either water arsenic or urinary arsenic after adjustment for multiple comparisons. Conclusions: Our study identified urinary metabolites with long-term reproducibility that were associated with arsenic exposure. The data established the feasibility of using metabolomics in future larger studies. https://doi.org/10.1289/EHP1992
Repeated Slamming of Sandwich Composite Panels on Water

Wave slamming was simulated by repeatedly slamming rectangular sandwich composite specimens mounted on a rigid wedge with constant deadrise angle onto the body of calm water at various energy levels. Under single slamming, peak pressures and strains on the specimens were consistently found near the keel, whereas the maximum damage was localized near the chine. Significant reduction in strength was observed resulting from a single slam even at a moderate slamming energy level that left no apparent/visible damage to the test panel. Similarly, a substantial reduction in strength was observed under repeated slamming at various energy levels. The results were corroborated with acoustic emission observations that indicated a substantial reduction in AE activity in slammed specimens. A methodology was developed for the quantitative assessment of remaining strength and damage accumulation in slammed specimens using AE technique. Face yielding and core crushing were found to be the dominant modes of failure.
Performance of toxicity probability interval based designs in contrast to the continual reassessment method

Toxicity probability interval designs have received increasing attention as a dose‐finding method in recent years. In this study, we compared the two‐stage, likelihood‐based continual reassessment method (CRM), modified toxicity probability interval (mTPI), and the Bayesian optimal interval design (BOIN) in order to evaluate each method's performance in dose selection for phase I trials. We use several summary measures to compare the performance of these methods, including percentage of correct selection (PCS) of the true maximum tolerable dose (MTD), allocation of patients to doses at and around the true MTD, and an accuracy index. This index is an efficiency measure that describes the entire distribution of MTD selection and patient allocation by taking into account the distance between the true probability of toxicity at each dose level and the target toxicity rate. The simulation study considered a broad range of toxicity curves and various sample sizes. When considering PCS, we found that CRM outperformed the two competing methods in most scenarios, followed by BOIN, then mTPI. We observed a similar trend when considering the accuracy index for dose allocation, where CRM most often outperformed both mTPI and BOIN. These trends were more pronounced with increasing number of dose levels. Copyright © 2016 John Wiley & Sons, Ltd.
Implicit parameters: dynamic scoping with static types

This paper introduces a language feature, called implicit parameters, that provides dynamically scoped variables within a statically-typed Hindley-Milner framework. Implicit parameters are lexically distinct from regular identifiers, and are bound by a special with construct whose scope is dynamic, rather than static as with let. Implicit parameters are treated by the type system as parameters that are not explicitly declared, but are inferred from their use. We present implicit parameters within a small call-by-name λ-calculus. We give a type system, a type inference algorithm, and several semantics. We also explore implicit parameters in the wider settings of call-by-need languages with overloading, and call-by-value languages with effects. As a witness to the former, we have implemented implicit parameters as an extension of Haskell within the Hugs interpreter, which we use to present several motivating examples.
Characteristics of Surface Acoustic Waves in (100) AlN/64oYX-LiNbO3 Structures

A-axis-oriented AlN films are deposited on the 64oYXLiNbO3 substrate by the RF magnetron sputtering method. The crystalline structure of the AlN films is determined and confirmed by X-ray diffraction. Phase velocity, coupling coefficient, and temperature coefficient of frequency (TCF) of surface acoustic waves (SAWs) in the (100) AlN/64oYXLiNbO3 structures with different thicknesses of AlN films are measured. Simulation results show good agreement with measurement data. The research results illustrate that the increase of the thickness of AlN films will increase the SAW velocity, decrease the coupling coefficient, and decrease the absolute value of TCF. SAW characteristics in the (100) AlN/64oYX-LiNbO3 structures with different electrical interfaces are investigated numerically. The effects of the polarity of the 64oYX-LiNbO3 substrate on SAW characteristics will be also discussed.
Comparison of GeneFinder human papillomavirus (HPV) Liquid Beads Microarray PCR Kit and Hybrid Capture 2 Assay for Detection of HPV Infection

Along with advances in methodological technologies, various assays for detecting high‐risk human papillomavirus (HR HPV) have been introduced. The GeneFinder HPV liquid beads microarray PCR kit is one of the recently developed. Our aim was to compare the performance of GeneFinder to Hybrid Capture 2 for detection of HR HPV.
Evaluation of romiplostim for the treatment of secondary failure of platelet recovery among allogeneic hematopoietic stem cell transplant patients

Secondary failure of platelet recovery (SFPR) is a serious complication observed in approximately 20% of allogeneic hematopoietic stem cell transplant (HSCT) recipients. Although the standard therapeutic approach has been frequent platelet transfusions, romiplostim, a thrombopoietin receptor agonist, may have utility in treating SFPR. The primary objective of this single-center retrospective analysis was to assess effectiveness of romiplostim for SFPR and to evaluate patient factors which may influence clinical outcomes. The primary outcome measure of response was defined as achievement of platelet count ≥ 50 × 109/L without transfusions for ≥ 7 consecutive days. During the study period, 93 patients underwent HSCT and 13 (13.9%) received romiplostim for SFPR. Seven patients (53.8%) responded to romiplostim, requiring a median of three doses (range 1–6) to achieve independence from platelet transfusions. Disease relapse occurred in 38.5% of all patients, two responders and three nonresponders. Median survival post-HSCT was 753 days among responders and 266 days among nonresponders (p = 0.0375). No serious adverse events were reported, and rates of graft-versus-host disease did not increase following administration of romiplostim. Thrombopoietin receptor agonists including romiplostim offer a treatment option for persistent thrombocytopenia following HSCT. Positive clinical response to romiplostim post-HSCT is associated with improved outcomes.