Miracle-dz/UniFAR-FTUs huggingface dataset:
Lobbying as Investment under Uncertainty

We consider a market which is protected against entry through legislation. While one lobby aims at opening the market so that prices decrease, the other lobby wants to maintain the status quo. The decision whether to open the market or not is made by a legislature that convenes every period and can be influenced through bribes. We analyze the strategic timing of lobbying, which is similar to investment decisions under uncertainty: For the deregulation lobby, is it better to attack the status quo today, or rather to wait? Similarly, how much should the incumbent lobby spend in order to defend the status quo against an attack, if one occurs? We derive the equilibrium of this game, and find the associated “attack threshold”. The main results are that the attack threshold is considerably lower than in a comparable one period game, and that the expenditure level necessary to change the status quo is low in comparison to the prize; this provides a possible solution for Tullock’s (1989) “rent seeking paradox”.
Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants

Homologues of the yeast ubiquitin ligase-associated protein SGT1 are required for disease resistance in plants mediated by nucleotide-binding site/leucine-rich repeat (NBS-LRR) proteins. Here, by silencing SGT1 in Nicotiana benthamiana, we extend these findings and demonstrate that SGT1 has an unexpectedly general role in disease resistance. It is required for resistance responses mediated by NBS-LRR and other R proteins in which pathogen-derived elicitors are recognized either inside or outside the host plant cell. A requirement also exists for SGT1 in nonhost resistance in which all known members of a host species are resistant against every characterized isolate of a pathogen. Our findings show that silencing SGT1 affects diverse types of disease resistance in plants and support the idea that R protein-mediated and nonhost resistance may involve similar mechanisms.
Anonymous or Not? Understanding the Factors Affecting Personal Mobile Data Disclosure

The wide adoption of mobile devices and social media platforms have dramatically increased the collection and sharing of personal information. More and more frequently, users are called to make decisions concerning the disclosure of their personal information. In this study, we investigate the factors affecting users’ choices toward the disclosure of their personal data, including not only their demographic and self-reported individual characteristics, but also their social interactions and their mobility patterns inferred from months of mobile phone data activity. We report the findings of a field study conducted with a community of 63 subjects provided with (i) a smart-phone and (ii) a Personal Data Store (PDS) enabling them to control the disclosure of their data. We monitor the sharing behavior of our participants through the PDS and evaluate the contribution of different factors affecting their disclosing choices of location and social interaction data. Our analysis shows that social interaction inferred by mobile phones is an important factor revealing willingness to share, regardless of the data type. In addition, we provide further insights on the individual traits relevant to the prediction of sharing behavior.
Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3

The endothelial cell (EC)–derived tissue inhibitor of metalloproteinase-2 (TIMP-2) and pericyte-derived TIMP-3 are shown to coregulate human capillary tube stabilization following EC–pericyte interactions through a combined ability to block EC tube morphogenesis and regression in three-dimensional collagen matrices. EC–pericyte interactions strongly induce TIMP-3 expression by pericytes, whereas ECs produce TIMP-2 in EC–pericyte cocultures. Using small interfering RNA technology, the suppression of EC TIMP-2 and pericyte TIMP-3 expression leads to capillary tube regression in these cocultures in a matrix metalloproteinase-1 (MMP-1)–, MMP-10–, and ADAM-15 (a disintegrin and metalloproteinase-15)–dependent manner. Furthermore, we show that EC tube morphogenesis (lumen formation and invasion) is primarily controlled by the TIMP-2 and -3 target membrane type (MT) 1 MMP. Additional targets of these inhibitors include MT2-MMP and ADAM-15, which also regulate EC invasion. Mutagenesis experiments reveal that TIMP-3 requires its proteinase inhibitory function to induce tube stabilization. Overall, these data reveal a novel role for both TIMP-2 and -3 in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.
Molecular and Genetic Characterization of Propionicin F, a Bacteriocin from Propionibacterium freudenreichii

ABSTRACT This work describes the purification and characterization of propionicin F, the first bacteriocin isolated from Propionibacterium freudenreichii. The bacteriocin has a bactericidal activity and is only active against strains of P. freudenreichii. Propionicin F appears to be formed through a processing pathway new to bacteriocins. The mass of the purified bacteriocin was determined by mass spectrometry, and the N-terminal amino acid sequence was determined by Edman degradation. Sequencing of pcfA, the bacteriocin structural gene, revealed that propionicin F corresponds to a 43-amino-acid peptide in the central part of a 255-amino-acid open reading frame, suggesting that mature propionicin F is excised from the probacteriocin by N- and C-terminal proteolytic modifications. DNA sequencing and Northern blot hybridizations revealed that pcfA is cotranscribed with genes encoding a putative proline peptidase and a protein from the radical S-adenosylmethionine family. A gene encoding an ABC transporter was also identified in close proximity to the bacteriocin structural gene. The potential role of these genes in propionicin F maturation and secretion is discussed.
Efficient assembly of full-length infectious clone of Brazilian IBDV isolate by homologous recombination in yeast

The Infectious Bursal Disease Virus (IBDV) causes immunosuppression in young chickens. Advances in molecular virology and vaccines for IBDV have been achieved by viral reverse genetics (VRG). VRG for IBDV has undergone changes over time, however all strategies used to generate particles of IBDV involves multiple rounds of amplification and need of in vitro ligation and restriction sites. The aim of this research was to build the world’s first VRG for IBDV by yeast-based homologous recombination; a more efficient, robust and simple process than cloning by in vitro ligation. The wild type IBDV (Wt-IBDV-Br) was isolated in Brazil and had its genome cloned in pJG-CMV-HDR vector by yeast-based homologous recombination. The clones were transfected into chicken embryo fibroblasts and the recovered virus (IC-IBDV-Br) showed genetic stability and similar phenotype to Wt-IBDV-Br, which were observed by nucleotide sequence, focus size/morphology and replication kinetics, respectively. Thus, IBDV reverse genetics by yeast-based homologous recombination provides tools to IBDV understanding and vaccines/viral vectors development.
Adverse health effects of high-effort/low-reward conditions.

In addition to the person-environment fit model (J. R. French, R. D. Caplan, & R. V. Harrison, 1982) and the demand-control model (R. A. Karasek & T. Theorell, 1990), a third theoretical concept is proposed to assess adverse health effects of stressful experience at work: the effort-reward imbalance model. The focus of this model is on reciprocity of exchange in occupational life where high-cost/low-gain conditions are considered particularly stressful. Variables measuring low reward in terms of low status control (e.g., lack of promotion prospects, job insecurity) in association with high extrinsic (e.g., work pressure) or intrinsic (personal coping pattern, e.g., high need for control) effort independently predict new cardiovascular events in a prospective study on blue-collar men. Furthermore, these variables partly explain prevalence of cardiovascular risk factors (hypertension, atherogenic lipids) in 2 independent studies. Studying adverse health effects of high-effort/low-reward conditions seems well justified, especially in view of recent developments of the labor market.
Similarity-Based Methods for Word Sense Disambiguation

We compare four similarity-based estimation methods against back-off and maximum-likelihood estimation methods on a pseudo-word sense disambiguation task in which we controlled for both unigram and bigram frequency. The similarity-based methods perform up to 40% better on this particular task. We also conclude that events that occur only once in the training set have major impact on similarity-based estimates.
Inferential language models for information retrieval

Language modeling (LM) has been widely used in IR in recent years. An important operation in LM is smoothing of the document language model. However, the current smoothing techniques merely redistribute a portion of term probability according to their frequency of occurrences only in the whole document collection. No relationships between terms are considered and no inference is involved. In this article, we propose several inferential language models capable of inference using term relationships. The inference operation is carried out through a semantic smoothing either on the document model or query model, resulting in document or query expansion. The proposed models implement some of the logical inference capabilities proposed in the previous studies on logical models, but with necessary simplifications in order to make them tractable. They are a good compromise between inference power and efficiency. The models have been tested on several TREC collections, both in English and Chinese. It is shown that the integration of term relationships into the language modeling framework can consistently improve the retrieval effectiveness compared with the traditional language models. This study shows that language modeling is a suitable framework to implement basic inference operations in IR effectively.
Robotic-Assisted Versus Laparoscopic Colectomy: Cost and Clinical Outcomes

Background and Objectives: Laparoscopic colectomies, with and without robotic assistance, are performed to treat both benign and malignant colonic disease. This study compared clinical and economic outcomes for laparoscopic colectomy procedures with and without robotic assistance. Methods: Patients aged ≥18 years having primary inpatient laparoscopic colectomy procedures (cecectomy, right hemicolectomy, left hemicolectomy, and sigmoidectomy) identified by International Classification of Diseases, Ninth Edition procedure codes performed between 2009 and the second quarter of 2011 from the Premier Hospital Database were studied. Patients were matched to a control cohort using propensity scores for disease, comorbidities, and hospital characteristics and were matched 1:1 for specific colectomy procedure. The outcomes of interest were hospital cost of laparoscopic robotic-assisted colectomy compared with traditional laparoscopic colectomy, surgery time, adverse events, and length of stay. Results: Of 25 758 laparoscopic colectomies identified, 98% were performed without robotic assistance and 2% were performed with robotic assistance. After matching, 1066 patients remained, 533 in each group. Lengths of stay were not significantly different between the matched cohorts, nor were rates of major, minor, and/or surgical complications. Inpatient procedures with robotic assistance were significantly more costly than those without robotic assistance ($17 445 vs $15 448, P = .001). Operative times were significantly longer for robotic-assisted procedures (4.37 hours vs 3.34 hours, P < .001). Conclusion: Segmental colectomies can be performed safely by either laparoscopic or robotic-assisted methods. Increased per-case hospital costs for robotic-assisted procedures and prolonged operative times suggest that further investigation is warranted when considering robotic technology for routine laparoscopic colectomies.
Effectiveness of psychotherapy for severe somatoform disorder: meta-analysis.

BACKGROUND Patients with severe somatoform disorder (in secondary and tertiary care) typically experience functional impairment associated with physical symptoms and mental distress. Although psychotherapy is the preferred treatment, its effectiveness remains to be demonstrated. AIMS To examine the effectiveness of psychotherapy for severe somatoform disorder in secondary and tertiary care compared with treatment as usual (TAU) but not waiting-list conditions. METHOD Main inclusion criteria were presence of a somatoform disorder according to established diagnostic criteria and receiving psychotherapy for somatoform disorder in secondary and tertiary care. Both randomised and non-randomised trials were included. The evaluated outcome domains were physical symptoms, psychological symptoms (depression, anxiety, anger, general symptoms) and functional impairment (health, life satisfaction, interpersonal problems, maladaptive cognitions and behaviour). RESULTS Ten randomised and six non-randomised trials were included, comprising 890 patients receiving psychotherapy and 548 patients receiving TAU. Psychotherapy was more effective than TAU for physical symptoms (d = 0.80 v. d = 0.31, P<0.05) and functional impairment (d = 0.45 v. d = 0.15, P<0.01), but not for psychological symptoms (d = 0.75 v. d = 0.51, P = 0.21). These effects were maintained at follow-up. CONCLUSIONS Overall findings suggest that psychotherapy is effective in severe somatoform disorder. Future randomised controlled studies should examine specific interventions and mechanisms of change.
Robust Control and Model Uncertainty

where Q is a set of measures over c and x, and d is a discount rate. Gilboa and Schmeidler’s theory leaves open how to specify the set Q in particular applications. Criteria like (1) also appear as objective functions in robust-control theory. Robust-control theory specifies Q by taking a single “approximating model” and statistically perturbing it; Q is typically parameterized only implicitly, through a positive penalty variable u. This paper describes how to transform that “penalty problem” into a closely related “constraint problem” like (1). These two formulations differ in subtle ways but are connected via the Lagrange multiplier theorem. The implicit preference orderings differ but imply the same decisions. Both preferences are recursive, and therefore both are time-consistent. However, time consistency for the constraint specification requires that we introduce a new endogenous state variable to restrict how probability distortions are reconsidered at future dates. To facilitate comparisons to Anderson et al. (2000) and Zengjing Chen and Larry G. Epstein (2000), we cast our discussion within continuous-time diffusion models. I. A Benchmark Resource-Allocation Problem
Understanding how pharmacokinetic and pharmacodynamic differences of basal analog insulins influence clinical practice

Abstract This article reviews pharmacokinetic (PK) and pharmacodynamic (PD) concepts relating to the pharmacology of basal insulin analogs. Understanding the pharmacology of currently available long-acting basal insulins and the techniques used to assess PK and PD parameters (e.g. the euglycemic clamp method) is important when considering the efficacy and safety of these agents, and can help in understanding the rationale for specific dosing strategies when tailoring therapy for a specific patient. Basal insulins such as insulin glargine 100 units (U)/mL and insulin detemir show improved PK/PD characteristics compared with the intermediate-acting NPH insulin, with a longer duration of action, a more consistent glucose-lowering effect and less prominent concentration peaks. However, more recently developed basal insulins (insulin glargine 300 U/mL, and insulin degludec 100 U/mL and 200 U/mL) have PK/PD profiles closer to the physiologic profile of endogenous basal insulin owing to a more evenly distributed, predictable and prolonged time–action profile that exceeds 24 hours and improved within-patient variability in glucose-lowering effect. The clinical implications and relevance of these PK/PD profiles is explored, including the potential effect of PK/PD parameters on glycemic control and hypoglycemia, and the timing of dosing. The improved PK/PD properties of newer longer-acting basal insulins may translate into clinical benefits for patients with type 1 and type 2 diabetes, such as more consistent insulin levels in the blood over 24 hours, lower intra-patient variability, a reduced risk of nocturnal hypoglycemia, and more flexibility in dosing time, all of which are important to consider when choosing a basal insulin regimen.
Embedding NSM FRP Plates for Improved IC Debonding Resistance

The use of near surface mounted (NSM) fiber reinforced polymer (FRP) strips for strengthening reinforced concrete structures shows great promise as the strains at intermediate crack (IC) debonding are generally much greater than for externally bonded FRP strips. In this research, the NSM technique is taken a step further by embedding the NSM strip, i.e., is by providing cover to the strip. It is shown that embedment can increase the IC debonding resistance by up to three times. Importantly, embedment allows: substantially larger strains at IC debonding and, hence, greater ductility; the use of larger cross sections of FRP plate; and, through providing cover to the NSM, may be the first step in enhancing the fire resistance. In this paper, 20 new pull tests are described from which mathematical expressions are developed for the effect of embedment on both the IC debonding resistance and its associated local bond stress–slip (τ–δ) relationship.
2013 7th International Conference on Pervasive Computing Technologies for Healthcare and Workshops Designing for Positive Health Affect Decoupling Negative Emotion and Health Monitoring Technologies

Through various health-focused technology proj ects, we discovered that the emotional response to technology was related to uptake and sustained use of health monitoring technologies. In this paper we present a case study of how we synthesized constructs of social cognitive theory, technology as experience, and diabetes management guidelines as a framework for making design recommendations for blood glucose monitoring technology that address the emotional response of users. We suggest applying this theoretical lens for design may help attend to emotional responses of users in an effort to decouple strong negative emotions that are paired to health monitoring technologies that provide a single value health result.
Neurite Outgrowth in PC12 Cells

Nerve growth factor (NGF)-induced neurite outgrowth from rat PC12 cells was coincident with elevated (≥2-fold) levels of endogenous ubiquitin (Ub) protein conjugates, elevated rates of formation of 125I-labeled Ub∼E1 (Ub-activating enzyme) thiol esters and 125I-labeled Ub∼E2 (Ub carrier protein) thiol esters in vitro, and enhanced capacity to synthesize 125I-labeled Ub-protein conjugates de novo. Activities of at least four E2s were increased in NGF-treated cells, including E2(14K), a component of the N-end rule pathway. Ubiquitylation of 125 I-labeled β-lactoglobulin was up to 4-fold greater in supernatants from NGF-treated cellsversus untreated cells and was selectively inhibited by the dipeptide Leu-Ala, an inhibitor of Ub isopeptide ligase (E3). However, Ub-dependent proteolysis of 125I-labeled β-lactoglobulin was not increased in supernatants from NGF-treated cells, suggesting that neurite outgrowth is promoted by enhanced rates of synthesis (rather than degradation) of Ub-protein conjugates. Consistent with this observation, neurite outgrowth was induced by proteasome inhibitors (lactacystin and clasto-lactacystin β-lactone) and was associated with elevated levels of ubiquitylated protein and stabilization of the Ub-dependent substrate, p53. Lactacystin-induced neurite outgrowth was blocked by the dipeptide Leu-Ala (2 mm) but not by His-Ala. These data 1) demonstrate that the enhanced pool of ubiquitylated protein observed during neuritogenesis in PC12 cells reflects coordinated up-regulation of Ub-conjugating activity, 2) suggest that Ub-dependent proteolysis is a negative regulator of neurite outgrowth in vitro, and 3) support a role for E2(14K)/E3-mediated protein ubiquitylation in PC12 cell neurite outgrowth.
Second order averaging methods for oscillatory control of underactuated mechanical systems

This paper considers the stabilization of underactuated mechanical systems via high-amplitude, high-frequency actuation. Using higher order averaging techniques, we extend previous work to the case where symmetric products of order higher than one are necessary for controllability. We first introduce a second order averaged mechanical system model that incorporates higher order terms. Using this result, we obtain trajectory tracking in the average by feeding back an error signal that is constant over whole periods of the oscillatory actuation. A simulation demonstrates the method.
Whither pathogenetic treatments for diabetic polyneuropathy?

Diabetic distal symmetric polyneuropathy (DSPN) occurs in around one‐third of patients with diabetes and is associated with significant morbidity and increased mortality. Diagnosis and clinical assessment of DSPN remain a challenge, not only for the physician in clinical practice but also for clinical trials. Optimal diabetes control is generally considered an essential first step in the prevention and management of DSPN. However, glycaemic control alone may be insufficient to prevent the development or progression of DSPN, especially in type 2 diabetes. Near‐normoglycaemia is also difficult to achieve in a significant proportion of patients. Although considerable advances have been made in symptomatic pain management, these have not addressed the problem of sensory deficits and have no impact on the underlying pathogenesis of DSPN. There remains a lack of treatment options that effectively target the natural history of the disease. Several pathogenetic treatment approaches have been investigated, but evidence from clinical trials is limited with a number of treatments having shown disappointing results. However, some pathogenetic therapies have shown clinically relevant improvements in neuropathic endpoints in randomised controlled trials, in particular α‐lipoic acid and Actovegin. These advances in DSPN disease modification need to be confirmed with further robust evidence from clinical trials together with a better understanding of the mechanisms of action of promising treatments. Copyright © 2013 John Wiley & Sons, Ltd.