Miracle-dz/UniFAR-FTUs huggingface dataset:
SampleAhead: Online Classifier-Sampler Communication for Learning from Synthesized Data

State-of-the-art techniques of artificial intelligence, in particular deep learning, are mostly data-driven. However, collecting and manually labeling a large scale dataset is both difficult and expensive. A promising alternative is to introduce synthesized training data, so that the dataset size can be significantly enlarged with little human labor. But, this raises an important problem in active vision: given an {\bf infinite} data space, how to effectively sample a {\bf finite} subset to train a visual classifier? This paper presents an approach for learning from synthesized data effectively. The motivation is straightforward -- increasing the probability of seeing difficult training data. We introduce a module named {\bf SampleAhead} to formulate the learning process into an online communication between a {\em classifier} and a {\em sampler}, and update them iteratively. In each round, we adjust the sampling distribution according to the classification results, and train the classifier using the data sampled from the updated distribution. Experiments are performed by introducing synthesized images rendered from ShapeNet models to assist PASCAL3D+ classification. Our approach enjoys higher classification accuracy, especially in the scenario of a limited number of training samples. This demonstrates its efficiency in exploring the infinite data space.
An Anatomically Resolved Mouse Brain Proteome Reveals Parkinson Disease-relevant Pathways *

Here, we present a mouse brain protein atlas that covers 17 surgically distinct neuroanatomical regions of the adult mouse brain, each less than 1 mm3 in size. The protein expression levels are determined for 6,500 to 7,500 gene protein products from each region and over 12,000 gene protein products for the entire brain, documenting the physiological repertoire of mouse brain proteins in an anatomically resolved and comprehensive manner. We explored the utility of our spatially defined protein profiling methods in a mouse model of Parkinson's disease. We compared the proteome from a vulnerable region (substantia nigra pars compacta) of wild type and parkinsonian mice with that of an adjacent, less vulnerable, region (ventral tegmental area) and identified several proteins that exhibited both spatiotemporal- and genotype-restricted changes. We validated the most robustly altered proteins using an alternative profiling method and found that these modifications may highlight potential new pathways for future studies. This proteomic atlas is a valuable resource that offers a practical framework for investigating the molecular intricacies of normal brain function as well as regional vulnerability in neurological diseases. All of the mouse regional proteome profiling data are published on line at http://mbpa.bprc. ac.cn/.
Pancreatic Ascites and Pleural Effusion

Pancreatic ascites or internal pancreatic fistulae and pancreatic pleural effusion are rare complications of pancreatitis. This can occur in the clinical setting of an acute pancreatitis and more commonly as a complication of chronic pancreatitis1. This is an uncommon clinical condition; often the patients are sick and nutritionally compromised. Pancreatic ascites was first reported in the literature in 1953 when Smith described two cases of ascites associated with chronic pancreatitis2.
Target localization for post‐prostatectomy patients using CT and ultrasound image guidance

We conducted a study comparing B‐mode acquisition and targeting (BAT) ultrasound alignments based on CT data in the postoperative setting. CT scans were obtained with a Primatom CT‐on‐rails on nine patients. Two CT scans were obtained each week, while setup error was minimized by BAT ultrasounds. For the first three patients, a direct comparison was performed. For the next six patients, a template based on the shifts from the week 1 CT during treatment was used for subsequent setup. Comparison of isocenter shifts between the BAT ultrasound and CT was made by the difference, absolute difference, and improvement (using CT alignments as the reference technique). A total of 90 image comparisons were made. The average interfraction motion was 3.2 mm in the lateral, 3.0 mm in the longitudinal, and 5.1 mm in the AP direction. The results suggest that the CT‐based ultrasound templates can improve the localization of the prostate bed when the initial displacements are greater than 4 mm. For initial displacements smaller than 4 mm, the technique neither improved nor worsened target localization. However, ultrasound alignments performed without the use of a template deteriorated patient positioning for two out of three patients, demonstrating that the use of a CT template was beneficial even at small initial displacements. PACS numbers: 87.53. ‐j, 87.53. Kn, 87.53. Xd
Fabrication and characterization of Polymer laminate composites reinforced with bi-woven carbon fibers

The present paper evaluate slaminatedcarbonbi-wove fibers Reinforced with vinyl ester composites. Vinyl ester was used as a matrix to prepare composites by in situ polymerization technique. Four planar layers were made simultaneously by keeping one over the other and each layer made sure to be weighed off by 15% which was maintained in all layers with different orientations. Pre-assumed Layer-1 is (50/50)50%,0o; Layer-2 is (35/35/30) 35% 0o, 35% +45o,30%,0;Layer-3is (25/50/25) 25% 0o, 50%+45o,25-45o; and Layer-4is (25/25/25/25) (25% 0o, 25% +45o,25% -45o,25% 90o.The composite was prepared with the help of hand layup technique. Test ready specimens were tested with the help of shearing machine in accordance with ASTM Standards . It was observed that vinyl ester made good interface with parent fiber material. Flexural strength and Tensile strength have improved up to 3rd layer and decreased afterwards whereas Flexural modulus and Tensile modulus have linearly increased up to 4 th layer. Thermal stability and Glass transition temperature have also been found to be satisfactory for all the laminated layers. Chemical resistance was good for the entire chemicals except sodium hydroxide.
Ethnobotanical, Ethnopharmacological, and Phytochemical Studies of Myrtus communis Linn: A Popular Herb in Unani System of Medicine

Myrtus communis L (Myrtaceae) is one of the popular drugs being used in the Unani system of phytomedicine since ancient Greece period. From time immemorial, different parts of this plant and essential oil have been used for a variety of purposes such as cosmetics (hair fall control), flavoring of food and drinks as well as extensive therapeutic purposes. Ethnobotanical information revealed that M communis L has been a folkloric repute for the treatment of several diseases like gastric ulcer, diarrhea, dysentery, cancer, rheumatism, hemorrhage, deep sinuses, leucorrhoea, hemorrhoid, inflammation, dyspepsia, anxiety, insomnia, diabetes, hypertension, pulmonary disorders, and skin diseases. Moreover, ethnopharmacological studies revealed that the plant is endowed with extensive pharmacological activities, including antimicrobial, antidiarrheal, antidiabetic, antispasmodic, vasodilator, antiulcer, antioxidant, anticancer, anxiolytic, sedative-hypnotic, and anti-inflammatory activities, among others. The plant has been known to contain phenolic acids, tannins, flavonoids, glycosides, and terpenes. The myrtle oil was also found to be rich in a variety of bioactive monoterpenes and sesquiterpenes with their derivatives. Most of these studies validate the aforementioned traditional claims of this medicinal plant. Further studies are needed to unravel other pharmacological activities of this plant in the long run.
Risks Associated With Anesthesia Services During Colonoscopy.

BACKGROUND & AIMS We aimed to quantify the difference in complications from colonoscopy with vs without anesthesia services. METHODS We conducted a prospective cohort study and analyzed administrative claims data from Truven Health Analytics MarketScan Research Databases from 2008 through 2011. We identified 3,168,228 colonoscopy procedures in men and women, aged 40-64 years old. Colonoscopy complications were measured within 30 days, including colonic (ie, perforation, hemorrhage, abdominal pain), anesthesia-associated (ie, pneumonia, infection, complications secondary to anesthesia), and cardiopulmonary outcomes (ie, hypotension, myocardial infarction, stroke), adjusted for age, sex, polypectomy status, Charlson comorbidity score, region, and calendar year. RESULTS Nationwide, 34.4% of colonoscopies were conducted with anesthesia services. Rates of use varied significantly by region (53% in the Northeast vs 8% in the West; P < .0001). Use of anesthesia service was associated with a 13% increase in the risk of any complication within 30 days (95% confidence interval [CI], 1.12-1.14), and was associated specifically with an increased risk of perforation (odds ratio [OR], 1.07; 95% CI, 1.00-1.15), hemorrhage (OR, 1.28; 95% CI, 1.27-1.30), abdominal pain (OR, 1.07; 95% CI, 1.05-1.08), complications secondary to anesthesia (OR, 1.15; 95% CI, 1.05-1.28), and stroke (OR, 1.04; 95% CI, 1.00-1.08). For most outcomes, there were no differences in risk with anesthesia services by polypectomy status. However, the risk of perforation associated with anesthesia services was increased only in patients with a polypectomy (OR, 1.26; 95% CI, 1.09-1.52). In the Northeast, use of anesthesia services was associated with a 12% increase in risk of any complication; among colonoscopies performed in the West, use of anesthesia services was associated with a 60% increase in risk. CONCLUSIONS The overall risk of complications after colonoscopy increases when individuals receive anesthesia services. The widespread adoption of anesthesia services with colonoscopy should be considered within the context of all potential risks.
Genotyping Natural Killer Immune Checkpoints to Discover Biomarkers of Response

Immune checkpoints have been a focus of immunotherapy in the recent decade. Killer cell immunoglobulin-like receptors (KIR) and their cognate human leukocyte antigen (HLA) class I ligands have evolved as checkpoints to ensure self-tolerance of natural killer cells. Both KIR and HLA genetic profiles are potential biomarkers of immunotherapy outcome. Clin Cancer Res; 24(1); 3–5. ©2017 AACR. See related article by Erbe et al., p. 189
Does gated beam delivery impact delivery accuracy on an Elekta linac?

Abstract In this study, we evaluated the performance of an Elekta linac in the delivery of gated radiotherapy. Delivery accuracy was examined with an emphasis on the impact of using short gating windows (low monitor unit beam‐on segments) or long beam hold times. The performance was assessed using a 20cm by 20cm open field with the radiation delivered using a range of beam‐on and beam‐off time periods. Gated delivery measurements were also performed for two SBRT plans delivered using volumetric modulated arc therapy (VMAT). Tests included both free‐breathing based gating (covering a variety of gating windows) and simulated breath‐hold based gating. An IBA MatriXX 2D ion chamber array was used for data collection, and the gating accuracy at low MU was evaluated using gamma passing rates. For the 20 cm by 20 cm open field, the measurements generally showed close agreement between the gated and non‐gated beam deliveries. Discrepancies, however, began to appear with a 5‐to‐1 ratio of the beam‐off to beam‐on times. The discrepancies observed for these tight gating windows can be attributed to the small number of monitor units delivered during each beam‐on segment. Dose distribution analysis from the delivery of the two SBRT plans showed gamma passing rates (± 1%, 2%/1 mm) in the range of 95% to 100% for gating windows of 25%, 38%, 50%, 63%, 75%, and 83%. Using a simulated sinusoidal breathing signal with a 4 second period, the gamma passing rate of free‐breathing gating and breath‐hold gating deliveries were measured in the range of 95.7% to 100%. In conclusion, the results demonstrate that Elekta linacs can accurately deliver respiratory gated treatments for both free‐breathing and breath‐hold patients. Some caution should be exercised with the use of very tight gating windows.
An Improved DC Solid State Transformer Based on Switched Capacitor and Multiple-Phase-Shift Shoot-Through Modulation for Integration of LVDC Energy Storage System and MVDC Distribution Grid

This paper proposes an improved dc transformer (NDCT hereinafter) based on switched capacitor with reduced switches for the integration of low-voltage dc energy storage systems and medium-voltage dc power distribution grid. The topology, phase-shift (PS) shoot-through and multiple PS modulations, and voltage, current, and power characterizations, as well as commutation characterization and control strategy, are proposed and analyzed comprehensively. Compared with the traditional schemes, the proposed NDCT not only can enhance reliability and flexibility but can increase voltage adjustment and power transfer capabilities as well. Moreover, the current ripple performance and soft-switching performance are improved, and the number and capacity of switches are reduced, thereby increasing the efficiency and cost of the system. Finally, an NDCT prototype is built. Experimental results verify the correctness and effectively of the proposed solution.
Causative mutations and premature cardiovascular disease in patients with heterozygous familial hypercholesterolaemia

Background Familial hypercholesterolemia is a common autosomal dominant disease, caused by mutations leading to elevated low-density lipoprotein (LDL) cholesterol and, if untreated, to premature cardiovascular disease. Methods Patients (young adults with a family history of hypercholesterolaemia or premature cardiovascular disease) with LDL cholesterol concentration ≥4.9 mmol/l, after excluding Familial Combined Hyperlipidaemia, were evaluated for causative mutations, Dutch Lipid Clinic Network score calculation and non-invasive ultrasound examination of carotid arteries. Results Of the 263 patients, 210 were heterozygotes for LDL receptor (LDLR) mutations, four had APOB gene mutations, one PCSK9 gene mutation, while 48 had no evidence of mutations. Among 194 unrelated index cases 149 had mutations (77%). Among patients with LDLR mutations (n = 145), there were five compound heterozygotes, 75 patients with null mutations and 65 with missense mutations. As many as 178 patients underwent a follow-up and treatment (statin ± ezetimibe), achieving a mean reduction of 49% in LDL cholesterol, with 21% of patients reaching the LDL goal of 2.6 mmol/l. In a multivariate analysis, carotid plaques, at ultrasound examination, were associated with the presence of genetic mutation (p = 0.001), LDL cholesterol (p < 0.001), Dutch Lipid Clinic Network score (p < 0.001), independently of age, gender, smoking habits and systolic blood pressure. The presence of carotid plaque (p = 0.017), LDL cholesterol (p < 0.003), Dutch Lipid Clinic Network score (p < 0.001) were independently associated with premature cardiovascular disease. Conclusions We identified patients with causative mutations in 82% of the cases under study. In addition to LDL cholesterol and Dutch Lipid Clinic Network score, carotid plaques in ultrasound evaluation provide direct evidence of premature vascular disease and are associated with high risk for cardiovascular events.
Evaluating the Joint Toxicity of Two Benzophenone-Type UV Filters on the Green Alga Chlamydomonas reinhardtii with Response Surface Methodology

The widespread occurrence of benzophenone-type ultraviolet (UV) filter has raised the public concerns over the ecotoxicological effects of these chemicals. The present study assessed the joint toxicity of two representative benzophenones, benzophenone-1 (BP-1) and benzophenone-3 (BP-3), on the green alga Chlamydomonas reinhardtii using response surface methodologies (RSM). Specific growth rate and photosynthetic pigments were used as endpoints to evaluate the toxic effects. Generally, exposure to the combined BP-1 and BP-3 negatively affected cell growth and pigments production, with higher inhibitions at higher exposure concentrations. The simultaneous reduction in growth rate and pigments contents indicated that BP-1 and BP-3 regulated the growth of the tested alga by affecting the photosynthesis process. Results also showed that second order polynomial regression models fitted well with experimental results for all endpoints. The obtained regression models further indicated that the effects of the combination stemmed significantly from the linear concentration of BP-1 and BP-3. The overall results demonstrated that RSM could be a useful tool in ecotoxicological studies.
Random Access Preamble Design and Detection for Mobile Satellite Communication Systems

Reasonable design and effective detection of the random access preamble has become a challenging task due to the unique characteristics of mobile satellite communications. To tackle this challenge, we first design a universal long sequence structure by concatenating multiple short Zadoff–Chu sequences that are insensitive to carrier frequency offset (CFO), and then propose the new principles of parameter selection for short sequences to ensure the minimum utilization of root sequence and the independence of the cyclic shift offset on the beam radius. To further reduce the detection complexity and improve the multi-user access performance, a fast timing detection approach is also presented by leveraging the piecewise cumulative detection and the multi-peaks joint estimation to obtain an accurate timing advance for each access user. Simulation results and complexity analysis validate the effectiveness of the new preamble in a typical satellite communication environment, and reveal that the proposed timing detection can achieve the robustness to CFO and offer outstanding performance improvements especially in multi-user scenarios while having a notably reduced computational complexity.
Attenuated Human Parainfluenza Virus Type 1 Expressing Ebola Virus Glycoprotein GP Administered Intranasally Is Immunogenic in African Green Monkeys

ABSTRACT The recent 2014-2016 Ebola virus (EBOV) outbreak prompted increased efforts to develop vaccines against EBOV disease. We describe the development and preclinical evaluation of an attenuated recombinant human parainfluenza virus type 1 (rHPIV1) expressing the membrane-anchored form of EBOV glycoprotein GP, as an intranasal (i.n.) EBOV vaccine. GP was codon optimized and expressed either as a full-length protein or as an engineered chimeric form in which its transmembrane and cytoplasmic tail (TMCT) domains were replaced with those of the HPIV1 F protein in an effort to enhance packaging into the vector particle and immunogenicity. GP was inserted either preceding the N gene (pre-N) or between the N and P genes (N-P) of rHPIV1 bearing a stabilized attenuating mutation in the P/C gene (CΔ170). The constructs grew to high titers and efficiently and stably expressed GP. Viruses were attenuated, replicating at low titers over several days, in the respiratory tract of African green monkeys (AGMs). Two doses of candidates expressing GP from the pre-N position elicited higher GP neutralizing serum antibody titers than the N-P viruses, and unmodified GP induced higher levels than its TMCT counterpart. Unmodified EBOV GP was packaged into the HPIV1 particle, and the TMCT modification did not increase packaging or immunogenicity but rather reduced the stability of GP expression during in vivo replication. In conclusion, we identified an attenuated and immunogenic i.n. vaccine candidate expressing GP from the pre-N position. It is expected to be well tolerated in humans and is available for clinical evaluation. IMPORTANCE EBOV hemorrhagic fever is one of the most lethal viral infections and lacks a licensed vaccine. Contact of fluids from infected individuals, including droplets or aerosols, with mucosal surfaces is an important route of EBOV spread during a natural outbreak, and aerosols also might be exploited for intentional virus spread. Therefore, vaccines that protect against mucosal as well as systemic inoculation are needed. We evaluated a version of human parainfluenza virus type 1 (HPIV1) bearing a stabilized attenuating mutation in the P/C gene (CΔ170) as an intranasal vaccine vector to express the EBOV glycoprotein GP. We evaluated expression from two different genome positions (pre-N and N-P) and investigated the use of vector packaging signals. African green monkeys immunized with two doses of the vector expressing GP from the pre-N position developed high titers of GP neutralizing serum antibodies. The attenuated vaccine candidate is expected to be safe and immunogenic and is available for clinical development.
Some heavy metals concentration in water, muscles and gills of tilapia niloticus as biological indicator of Manzala Lake pollution.

Environmental pollution is a worldwide problem, heavy metals belonging to the most important pollutants. The progress of industries has led to increased emission of pollutants into ecosystems. Manzala Lake is one of the most important aqua systems, which receives disposal of industrial chemicals from many drains (such as Bahr ElBakar) and agricultural pollutions (from Bahr Hadose). In addition, it was contaminated by Cairo and Delta sewage drainage system [1]. Metals tend to accumulate in water and move up through the food chain. So, studies to ascertain the level of heavy metals in environment and determine potentially hazardous levels for human are necessary. It is well known that this metal easily accumulates in fish tissues such as bones, gills, kidneys, liver, and scales [2]. Heavy metal ions do not degrade into harmless end products and will be toxic to many life forms [3]. Due to their toxicity and accumulation in biota, determination the levels of heavy metals in commercial fish species have received considerable attention in different countries [4]. There has been an increasing interest in the utilization of fishes as bio-indicators of the integrity of aquatic environmental systems in recent years [5]. Fish lie at the top of the aquatic food chain and may concentrate large amounts of some metals from the water. Heavy metals enter the body of fish through the skin or gills via the dissolved phase and through the digestive tract via the food [6-8]. Because waters generally have low heavy metals levels, even when high concentrations are found on the bottom, food is a significant source of these elements for fish [9,10]. The concentration of heavy metal were found to be higher in the liver, kidneys and gills than in the gonad and muscle tissues in some fish species [12,13] and the concentrations in the tissue of freshwater fish vary considerably among different studies. Therefore, the aim of the present study was to investigate the bioaccumulation levels of the heavy metals: Lead (Pb), Cadmium (Cd), Iron (Fe ), Copper (Cu), and Zinc (Zn), and their accumulation in the muscle tissues and gills of the commercially important and common, eatable fishes (Tilapia niloticus) that are found in Manzala lake.