Miracle-dz/UniFAR-FTUs huggingface dataset:
A Delay from Diagnosis to Treatment Is Associated with a Decreased Overall Survival for Patients with Endometrial Cancer

Objectives While Caucasian women are more likely to be diagnosed with endometrial cancer compared to African-American women, the rate of mortality is higher for African Americans. The cause of this disparity is unknown. We analyzed the time interval from diagnosis of endometrial cancer to treatment as it pertains to race and socioeconomic factors and its possible impact on survival. Methods This was a retrospective, single institution chart review using a cancer registry database. We identified 889 patients who were diagnosed with endometrial cancer between January 2005 and June 2012. Clinicopathologic characteristics, demographics, insurance status, distance from medical center, body mass index (BMI), dates of diagnosis, and treatment were obtained from the medical records. Survival and association was determined by a one-way ANOVA test. Results At the time of the study, 699 patients were alive and 190 dead. The average age was noted to be 62 years (24–91 years). Stages I–IV disease accounted for 69, 6, 15, and 10%, respectively. White race accounted for 64%, African Americans 24%, and Hispanics 7% of our study population. Majority of patients were privately insured (n = 441) followed by Medicare (n = 375). The mean interval time from diagnosis to treatment was 47.5 days (0–363). A statistically significant difference was noted for this time interval with regard to both race and insurance status: white and African Americans (42.6 vs. 57.3 days, p = 0.048), privately insured and Medicare (38.4 vs. 54.1 days, p < 0.001). There was a significant association with increased risk of death with a longer delay (43.3 vs. 64.8 days, p < 0.001). No statistically significance was noted for distance from medical center or BMI. Conclusion A significant increase in interval of time from diagnosis to treatment of endometrial cancer was seen in both race and insurance status. A longer interval from diagnosis to treatment was associated mortality. The causes of these delays are likely multifactorial but deem further investigation given these data.
RoboBrain: Large-Scale Knowledge Engine for Robots

In this paper we introduce a knowledge engine, which learns and shares knowledge representations, for robots to carry out a variety of tasks. Building such an engine brings with it the challenge of dealing with multiple data modalities including symbols, natural language, haptic senses, robot trajectories, visual features and many others. The \textit{knowledge} stored in the engine comes from multiple sources including physical interactions that robots have while performing tasks (perception, planning and control), knowledge bases from the Internet and learned representations from several robotics research groups. We discuss various technical aspects and associated challenges such as modeling the correctness of knowledge, inferring latent information and formulating different robotic tasks as queries to the knowledge engine. We describe the system architecture and how it supports different mechanisms for users and robots to interact with the engine. Finally, we demonstrate its use in three important research areas: grounding natural language, perception, and planning, which are the key building blocks for many robotic tasks. This knowledge engine is a collaborative effort and we call it RoboBrain.
Disruption of Striated Preferentially Expressed Gene Locus Leads to Dilated Cardiomyopathy in Mice

Background— The striated preferentially expressed gene (Speg) generates 4 different isoforms through alternative promoter use and tissue-specific splicing. Depending on the cell type, Speg isoforms may serve as markers of striated or smooth muscle differentiation. Methods and Results— To elucidate function of Speg gene isoforms, we disrupted the Speg gene locus in mice by replacing common exons 8, 9, and 10 with a lacZ gene. &bgr;-Galactosidase activity was detected in cardiomyocytes of the developing heart starting at day 11.5 days post coitum (dpc). &bgr;-Galactosidase activity in other cell types, including vascular smooth muscle cells, did not begin until 18.5 dpc. In the developing heart, protein expression of only Speg&agr; and Speg&bgr; isoforms was present in cardiomyocytes. Homozygous Speg mutant hearts began to enlarge by 16.5 dpc, and by 18.5 dpc, they demonstrated dilation of right and left atria and ventricles. These cardiac abnormalities in the absence of Speg were associated with a cellular hypertrophic response, myofibril degeneration, and a marked decrease in cardiac function. Moreover, Speg mutant mice exhibited significant neonatal mortality, with increased death occurring by 2 days after birth. Conclusions— These findings demonstrate that mutation of the Speg locus leads to cardiac dysfunction and a phenotype consistent with a dilated cardiomyopathy.
The quantification of contacts with impact during professional rugby matches

To gain a complete understanding of a player’s total physiological stress exposure the measure of contact with impact in match situations must be addressed. The goal of this study was to quantify the contact stress players were exposed to in a rugby match. 7 Matches in a professional provincial rugby competition were analyzed to determine the frequency of the contact situations for each player. There were 386 (range 306 – 535) impact contacts per match. The forwards were involved in 68% impact contacts with 257 per match (range 199 – 389). The backline players were involved in 125 (range 93 - 148) impact contacts per match. The most frequently occurring impact contact for the whole team was contact with the ground, 108 impacts per match (range 70 – 133) followed by the scrum impact, 81 impacts per match (47 – 100). Lineout contact impacts were the least frequently observed with 2 per match (range 1 – 4). 80% of the impact contacts were recorded at a higher frequency when the team lost as opposed to when they won. These findings have the potential to influence how players are prepared for matches and managed over a season.
Generation of One-Sided Random Dynamical Systems by Stochastic Differential Equations

Let $Z$ be an $R^m$-valued semimartingale with stationary increments which is realized as a helix over a filtered metric dynamical system $S$. Consider a stochastic differential equation with Lipschitz coefficients which is driven by $Z$. We show that its solution semiflow $\phi$ has a version for which $\varphi(t,\omega)=\phi(0,t,\omega)$ is a cocycle and therefore ($S$,$\varphi$) is a random dynamical system. Our results generalize previous results which required $Z$ to be continuous. We also address the case of local Lipschitz coefficients with possible blow-up in finite time. Our abstract perfection theorems are designed to cover also potential applications to infinite dimensional equations.
The orbital modulation in the radio emission of Cygnus X-1

We present model light curves which have been created in order to explain the orbital modulation observed in the radio emission of Cyg X-1. We invoke variable absorption by the stellar wind as the black hole jet orbits around the OB companion star and find that a very simple model is able to reproduce the amplitudes and frequency dependence of the observed light curves.
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase

The pim-1 kinase is a true oncogene that has been implicated in the development of leukemias, lymphomas, and prostate cancer, and is the target of drug development programs. We have used experimental approaches to identify a selective, cell-permeable, small-molecule inhibitor of the pim-1 kinase to foster basic and translational studies of the enzyme. We used an ELISA-based kinase assay to screen a diversity library of potential kinase inhibitors. The flavonol quercetagetin (3,3′,4′,5,6,7-hydroxyflavone) was identified as a moderately potent, ATP-competitive inhibitor (IC50, 0.34 μmol/L). Resolution of the crystal structure of PIM1 in complex with quercetagetin or two other flavonoids revealed a spectrum of binding poses and hydrogen-bonding patterns in spite of strong similarity of the ligands. Quercetagetin was a highly selective inhibitor of PIM1 compared with PIM2 and seven other serine-threonine kinases. Quercetagetin was able to inhibit PIM1 activity in intact RWPE2 prostate cancer cells in a dose-dependent manner (ED50, 5.5 μmol/L). RWPE2 cells treated with quercetagetin showed pronounced growth inhibition at inhibitor concentrations that blocked PIM1 kinase activity. Furthermore, the ability of quercetagetin to inhibit the growth of other prostate epithelial cell lines varied in proportion to their levels of PIM1 protein. Quercetagetin can function as a moderately potent and selective, cell-permeable inhibitor of the pim-1 kinase, and may be useful for proof-of-concept studies to support the development of clinically useful PIM1 inhibitors. [Mol Cancer Ther 2007;6(1):163–72]
An Open Architecture to Support Social and Health Services in a Smart TV Environment

Objective: To design, implement, and test a solution to provide social and health services for the elderly at home based on smart TV technologies and access to all services. Methods: The architecture proposed is based on an open software platform and standard personal computing hardware. This provides great flexibility to develop new applications over the underlying infrastructure or to integrate new devices, for instance to monitor a broad range of vital signs in those cases where home monitoring is required. Results: An actual system as a proof-of-concept was designed, implemented, and deployed. Applications range from social network clients to vital signs monitoring; from interactive TV contests to conventional online care applications such as medication reminders or telemedicine. Conclusion: In both cases, the results have been very positive, confirming the initial perception of the TV as a convenient, easy-to-use technology to provide social and health care. The TV set is a much more familiar computing interface for most senior users, and as a consequence, smart TVs become a most convenient solution for the design and implementation of applications and services targeted to this user group. Significance: This proposal has been tested in real setting with 62 senior people at their homes. Users included both individuals with experience using computers and others reluctant to them.
The Benefits of Cross-Racial Engagement on the College Satisfaction of Student-Athletes

Using nationally representative data from the 2010 NCAA Growth, Opportunities, Aspirations and Learning of Students in college (GOALS) survey, this study examines whether student-athletes’ cross-racial interactions correlate with their college satisfaction. Our findings suggest a small but statistically significant correlation between cross-racial interactions and satisfaction, but this relationship was partial mediated by the student-athlete perceptions of team inclusiveness culture. Findings and implications are discussed.
Analisis Kesulitan Belajar Mahasiswa pada Mata Kuliah Mekanika

Penelitian ini bertujuan untuk mengungkap hal-hal yang dianggap sebagai kesulitan belajar pada materi Mekanika. Penelitian ini merupakan penelitian deskriptif kualitatif yang berupaya untuk mendeskripsikan jenis-jenis kesulitan mahasiswa dalam menyelesaikan persoalan mekanika. Subjek dalam penelitian ini adalah mahasiswa semester tiga Pendidikan IPA IKIP Veteran Jawa Tengah yang mengambil mata kuliah Mekanika. Dalam penelitian ini, peneliti mengumpulkan informasi melalui tes diagnostik dan wawancara dengan mahasiswa. Instrumen yang digunakan dalam penelitian ini adalah tes diagnostik dan pedoman wawancara. Letak kesulitan belajar mahasiswa dilihat berdasarkan kesalahan yang dibuat dalam menyelesaikan tes diagnostik. Hasil analisis menunjukkan bahwa kesulitan belajar dalam mempelajari mekanika terletak pada kemampuan matematis dasar yaitu diferensial dan integral. Dengan demikian, pengajar perlu mengembangkan strategi pembelajaran sehingga kemampuan berpikir mahasiswa dalam memecahkan masalah semakin meningkat.
Dissipative instability of the MHD tangential discontinuity in magnetized plasmas with anisotropic viscosity and thermal conductivity

The stability of the MHD tangential discontinuity is studied in compressible plasmas in the presence of anisotropic viscosity and thermal conductivity. The general dispersion equation is derived, and solutions to this dispersion equation and stability criteria are obtained for the limiting cases of incompressible and cold plasmas. In these two limiting cases the effect of thermal conductivity vanishes, and the solutions are only influenced by viscosity. The stability criteria for viscous plasmas are compared with those for ideal plasmas, where stability is determined by the Kelvin—Helmholtz velocity VKH as a threshold for the difference in the equilibrium velocities. Viscosity turns out to have a destabilizing influence when the viscosity coefficient takes different values at the two sides of the discontinuity. Viscosity lowers the threshold velocity V below the ideal Kelvin—Helmholtz velocity VKH, so that there is a range of velocities between V and VKH where the overstability is of a dissipative nature.
Assessment of the MERS-CoV epidemic situation in the Middle East region

The appearance of a novel coronavirus named Middle East (ME) Respiratory Syndrome Coronavirus (MERS-CoV) has raised global public health concerns regarding the current situation and its future evolution. Here we propose an integrative maximum likelihood analysis of both cluster data in the ME region and importations in Europe to assess transmission scenario and incidence of sporadic infections. Our approach is based on a spatial-transmission model integrating mobility data worldwide and allows for variations in the zoonotic/environmental transmission and underascertainment. Maximum likelihood estimates for the ME region indicate the occurrence of a subcritical epidemic (R=0.50, 95% confidence interval (CI) 0.30-0.77) associated with a 0.28 (95% CI 0.12-0.85) daily rate of sporadic introductions. Infections in the region appear to be mainly dominated by zoonotic/environmental transmissions, with possible underascertainment (95% CI of estimated to observed sporadic cases in the range 1.03-7.32). No time evolution of the situation emerges. Analyses of flight passenger data from the region indicate areas at high risk of importation. While dismissing an immediate threat for global health security, this analysis provides a baseline scenario for future reference and updates, suggests reinforced surveillance to limit underascertainment, and calls for increased alertness in high-risk areas worldwide.
Be Conservative: Enhancing Failure Diagnosis with Proactive Logging

When systems fail in the field, logged error or warning messages are frequently the only evidence available for assessing and diagnosing the underlying cause. Consequently, the efficacy of such logging--how often and how well error causes can be determined via postmortem log messages--is a matter of significant practical importance. However, there is little empirical data about how well existing logging practices work and how they can yet be improved. We describe a comprehensive study characterizing the efficacy of logging practices across five large and widely used software systems. Across 250 randomly sampled reported failures, we first identify that more than half of the failures could not be diagnosed well using existing log data. Surprisingly, we find that majority of these unreported failures are manifested via a common set of generic error patterns (e.g., system call return errors) that, if logged, can significantly ease the diagnosis of these unreported failure cases. We further mechanize this knowledge in a tool called Errlog, that proactively adds appropriate logging statements into source code while adding only 1.4% performance overhead. A controlled user study suggests that Errlog can reduce diagnosis time by 60.7%.
Phase II Trial of the O6-Alkylguanine DNA Alkyltransferase Inhibitor O6-Benzylguanine and 1,3-Bis(2-Chloroethyl)-1-Nitrosourea in Advanced Melanoma

Purpose: 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) induces DNA damage via a chloroethyl adduct at the O6 position of guanine, which can be repaired by O6-alkylguanine DNA alkyltransferase (AGT) expressed in melanoma. We postulated that the addition of O6 benzylguanine (O6BG), a potent inactivator of AGT, would improve the clinical response to BCNU in melanoma. Experimental Design: Patients had measurable disease, adequate organ function, and a corrected Diffusing capacity of the lung for carbon monoxide (DLCO) of ≥70% predicted. They were accrued into two cohorts based on prior chemotherapy. O6BG (120 mg/m2) was administered i.v. followed by BCNU (40 mg/m2) on an outpatient basis. Peripheral blood mononuclear cells (PBMC) were collected pre- and 18 hours post-O6BG to analyze AGT depletion. Treatment was every 6 weeks, and clinical response was assessed after every two cycles. Results: Forty-two patients were enrolled, 22 of these patients were chemotherapy-naïve. In the chemotherapy-naïve cohort, there was a patient with a complete response (CR), 4 with stable disease (SD), 13 with progressive disease (PD), and 4 nonevaluable patients; the median time to progression was 80 days and the median survival was 211 days. In the prior-chemotherapy cohort, there were no responses, 3 SD, 15 PD, and 2 nonevaluable patients; median time to progression was 54 days and median survival was 120 days. AGT was depleted from PBMC in the 15 patients tested. Grades 3 to 4 myelosuppression was seen in 57% of patients; toxicities were similar between the two cohorts. Conclusions:O6BG/BCNU was successfully administered on an outpatient basis and depleted AGT from PBMC. However, significant myelosuppression was observed and the clinical outcome was not improved. Alternative mechanisms of resistance to melanoma cell death need to be investigated.
The relationship between the serum levels of ferritin and the radiological brain injury indices in patients with spontaneous intracerebral hemorrhage

Objective(s): Preclinical studies show that iron plays a key role in mediating neuronal injury. This study was performed in order to identify the relationship between the serum level of ferritin and severity of the brain injury which occur after an Intracerebral hemorrhage (ICH). Materials and Methods: This was a cross sectional descriptive - analytic study, which was conducted on those patients who had suffered from an ICH and had attended Poursina Hospital. The Serum levels of ferritin were measured at admittance. A Cranial CT scan was performed at admission and also 72 hr afterward. Hematoma and edema surrounding the hematoma volumes were also measured at entrance and 72 hr afterward. Data analysis was carried out by a descriptive - analytic statistics approach and calculated later on by the Spss-20 software. Results: In this investigation, 63 patients were studied, from which 34 (54%) were male and 29 (46%) female. The average age of the patients was 69.7± 11.9 (Min 43 and Max 94 years old). A significant relationship was observed between the level of ferritin and the edema volume surrounding the hematoma at first and next 72 hr after the patients were admitted. Conclusion: These results delineated the effective role of iron on the edema volume elevation. More studies are essentially urged to ascertain the clinical evaluation of the curing effect of iron chelators in those patients who suffer from ICH.
An Information Theoretic Perspective on the Differential Fault Analysis against AES

Differential Fault Analysis against AES has been actively studied these years. Based on similar assumptions of the fault injection, different DFA attacks against AES have been proposed. However, it is difficult to understand how different attack results are obtained for the same fault injection. It is also difficult to understand the relationship between similar assumptions of fault injection and the corresponding attack results. This paper reviews the previous DFA attacks against AES based on the information theory, and gives a general and easy understanding of DFA attacks against AES. We apply the similar analysis on DFA attacks on AES-192 and AES-256, and we propose the attack procedures to reach the theoretical minimal number of fault injections.
ERP implementations and their impact upon management accountants

This paper considers the impact of ERP implementations upon the role of management accountants, upon management accounting in general, and upon business processes. It does so in the context of the perceived success of the ERP implementation. A postal questionnaire was circulated to almost 700 management accountants working in large UK-based organisations. It finds that under successful ERP implementations, management accountants have time for other, less mundane activities and their role becomes more enriching. In contrast, when the implementation is unsuccessful, the role of the management accountant increases: the ERP system deficiencies require increased activity on their part without any noticeable reduction in the tasks they traditionally perform.
Variations in Mean Stomach Content Weights of Walleye Pollock, Theragra chalcogramma, in the Eastern Bering Sea

Variations in mean stomach contentweights (as-percentage of body weight) of walleye pollock, Theraqra chalcosramma, collected in the eastern Bering Sea from 1981 to 1987 were analyzed. The, results of a one-way analysis of variance (ANOVA) showed that bottom depth and prey type explained the highest proportions of the total variation in stomach content weights (5.7% and 4.6.% respectively), followed by season and year with 3.8% and 2.8%. of the total variation, respectively. Time of day and predator length were not important factors. , They explained only 1% and 0.04% of the total variation, respectively. In general, the mean stomach content weights were low in the continental slope area and high in the continental shelf area. , Because this phenomenon does not reflect the abundance of zooplankton, and because the percentage of empty stomachs increases as the bottom depth increases, it is suggested that undetected regurgitation played an important role in the variation of the stomach content weights. Walleye pollock that ate both fish and invertebrates had significantly higher stomach content weights than those that ate only invertebrates. Prey type or size, therefore, is probably one of the determinant-s of the gastric evacuation rate. Abstract Introduction Methods Data Collection Data Analysis Results General Description Depth Effect Prey Type Effect Interannual Variations Discussion Prey Type Effect Depth Effect . Acknowledgments. Citations Appendix iii Introduction Methods Data Collection Data Analysis Results General Description Depth Effect Prey Type Effect Interannual Variations Discussion Prey Type Effect Depth Effect . Acknowledgments. Citations Appendix iii