Miracle-dz/UniFAR-FTUs huggingface dataset:
Cytoarchitecture, fiber connections, and some histochemical aspects of the interpeduncular nucleus in the rat

The organization of afferent and efferent connections of the interpeduncular nucleus (IP) has been examined in correlation with its subnuclear parcellation by using anterograde and retrograde tracing techniques. Based on Nissl, myelin, and acetylcholinesterase staining five paired and three unpaired IP subnuclei are distinguished. The unpaired division includes the rostral subnucleus (IP‐R), the apical subnucleus (IP‐A), and the central subnucleus (IP‐C). The subnuclei represented bilaterally are the paramedian dorsal medial (IP‐DM) and intermediate subnuclei (IP‐I) and the laterally placed rostral lateral (IP‐RL), dorsal lateral (IP‐DL), and lateral subnuclei (IP‐L). Immunohistochemical techniques showed cell bodies and fibers and terminals immunoreactive for substance P, leuenkephalin, metenkephalin, or serotonin to be differentially distributed over the different IP subnuclei. Substance P‐positive perikarya were found in IP‐R, enkephalin neurons in IP‐R, IP‐A, and the caudodorsal part of IP‐C, and serotonin‐containing cell bodies in IP‐A and the caudal part of IP‐L.
Detecting and Solving Hyperbolic Quadratic Eigenvalue Problems

Hyperbolic quadratic matrix polynomials $Q(\lambda) = \lambda^2 A + \lambda B + C$ are an important class of Hermitian matrix polynomials with real eigenvalues, among which the overdamped quadratics are those with nonpositive eigenvalues. Neither the definition of overdamped nor any of the standard characterizations provides an efficient way to test if a given $Q$ has this property. We show that a quadratically convergent matrix iteration based on cyclic reduction, previously studied by Guo and Lancaster, provides necessary and sufficient conditions for $Q$ to be overdamped. For weakly overdamped $Q$ the iteration is shown to be generically linearly convergent with constant at worst $1/2$, which implies that the convergence of the iteration is reasonably fast in almost all cases of practical interest. We show that the matrix iteration can be implemented in such a way that when overdamping is detected a scalar $\mu<0$ is provided that lies in the gap between the $n$ largest and $n$ smallest eigenvalues of the $n \times n$ quadratic eigenvalue problem (QEP) $Q(\lambda)x = 0$. Once such a $\mu$ is known, the QEP can be solved by linearizing to a definite pencil that can be reduced, using already available Cholesky factorizations, to a standard Hermitian eigenproblem. By incorporating an initial preprocessing stage that shifts a hyperbolic $Q$ so that it is overdamped, we obtain an efficient algorithm that identifies and solves a hyperbolic or overdamped QEP maintaining symmetry throughout and guaranteeing real computed eigenvalues.
Prevalence of Mental Health Problems and Associated Risk Factors among Rural-to-Urban Migrant Children in Guangzhou, China

Rural-to-urban migration, which has achieved a huge scale during China’s economic reform, is a potential risk factor for the mental health of migrant children. To test this hypothesis, this study assessed the mental health status of rural-to-urban migrant children. Guided by Andersen’s behavioral model, the study explored the risk factors associated with mental health. The study recruited 1182 fifth/sixth-grade children from four private and four public primary schools in Guangzhou in 2014 in a descriptive cross-sectional design. Mental health status was measured by the strengths and difficulties questionnaire. Predisposing characteristics including demographics (e.g., age, gender), social structure (e.g., education, occupation) and health beliefs (health attitude) were recorded. Enabling characteristics including family and community resources and the need for health services were analyzed to explore the risk factors. The results indicate that more rural-to-urban migrant children were classified in the abnormal (21.0%) or borderline (18.8%) categories based on the total difficulties scores, the proportions of which were much higher than those of local children (9.8% abnormal, 13.8% borderline). Factors associated with a greater likelihood of mental health problems included single-parent families, seeking health information actively, family income cannot meet basic needs and poor perceived health status. Compared with the local children, the rural-to-urban migrant children had relatively poor mental health, hence monitoring and supporting mental health for rural-urban migrant children is critical.
The asymptotic variance of departures in critically loaded queues

We consider the asymptotic variance of the departure counting process D(t) of the GI/G/1 queue; D(t) denotes the number of departures up to time t. We focus on the case where the system load ϱ equals 1, and prove that the asymptotic variance rate satisfies lim t→∞varD(t) / t = λ(1–2/π)(c a 2 + c s 2), where λ is the arrival rate, and c a 2 and c s 2 are squared coefficients of variation of the interarrival and service times, respectively. As a consequence, the departures variability has a remarkable singularity in the case in which ϱ equals 1, in line with the BRAVO (balancing reduces asymptotic variance of outputs) effect which was previously encountered in finite-capacity birth-death queues. Under certain technical conditions, our result generalizes to multiserver queues, as well as to queues with more general arrival and service patterns. For the M/M/1 queue, we present an explicit expression of the variance of D(t) for any t.
Assessing cost-effectiveness in the management of multiple sclerosis

Multiple sclerosis (MS) is one of the most common causes of neurological disability in young and middle-aged adults, with current prevalence rates estimated to be 30 per 100,000 populations. Women are approximately twice as susceptible as males, but males are more likely to have progressive disease. The onset of the disease normally occurs between 20 and 40 years of age, with a peak incidence during the late twenties and early thirties, resulting in many years of disability for a large proportion of patients, many of whom require wheelchairs and some nursing home or hospital care. The aim of this study is to update a previous review which considered the cost-effectiveness of disease-modifying drugs (DMDs), such as interferons and glatiramer acetate, with more up to date therapies, such as mitaxantrone hydrochloride and natalizumab in the treatment of MS. The development and availability of new agents has been accompanied by an increased optimism that treatment regimens for MS would be more effective; that the number, severity and duration of relapses would diminish; that disease progression would be delayed; and that disability accumulation would be reduced. However, doubts have been expressed about the effectiveness of these treatments, which has only served to compound the problems associated with endeavors to estimate the relative cost-effectiveness of such interventions.
Modelling correlation as a stochastic process

Although market observations show that correlation between stocks, interest rates, e. g. , is not deterministic, correlation is usually modelled as a fixed number. This article provides a new approach of modelling correlation as a stochastic process which has applications in many fields. We will show an example from financial markets where the stochasticity of correlation is a fundamental source of risk: the quanto.
Thymosin beta 4 expression in normal skin, colon mucosa and in tumor infiltrating mast cells

Mast cells (MCs) are metachromatic cells that originate from multipotential hemopoietic stem cells in the bone marrow. Two distinct populations of MCs have been characterized: mucosal MCs are tryptase-positive while mast cells in skin contain tryptase and chymase. We now show that a sub-population of MCs is highly immunoreactive for thymosin β4, as revealed by immunohistochemical analyses of normal skin, normal colon mucosa and salivary gland tumors. Four consecutive serial sections from each case were immunostained for thymosin β4 (Tβ4), chymase, tryptase and stained for toluidine blue. In skin biopsies, MCs showed a comparable immunoreactivity for Tβ4, chymase and tryptase. In normal colon mucosa the vast majority of mucosal MCs expressed a strong cytoplasmic immunoreactivity for tryptase and for Tβ4, in the absence of chymase reactivity. A robust expression of Tβ4 was detected in tumor-infiltrating and peritumoral mast cells in salivary gland tumors and breast ductal infiltrating carcinomas. Tumorinfiltrating MCs also showed a strong immunoreactivity for chymase and tryptase. In this paper, we first demonstrate that normal dermal and mucosal mast cells exhibit strong expression of thymosin β4, which could be considered a new marker for the identification of mast cells in skin biopsies as well as in human tumors. The possible relationship between the degree of Tβ4 expression in tumor-infiltrating mast cells and tumor behaviour warrants further consideration in future investigations.
Modified Daily Undulating Periodization Model Produces Greater Performance Than a Traditional Configuration in Powerlifters

Abstract Zourdos, MC, Jo, E, Khamoui, AV, Lee, S-R, Park, B-S, Ormsbee, MJ, Panton, LB, Contreras, RJ, and Kim, J-S. Modified daily undulating periodization model produces greater performance than a traditional configuration in powerlifters. J Strength Cond Res 30(3): 784–791, 2016—The primary aim of this study was to compare 2 daily undulating periodization (DUP) models on one-repetition maximum (1RM) strength in the squat, bench press, deadlift, total volume (TV) lifted, and temporal hormone response. Eighteen male, college-aged (21.1 ± 1.9 years) powerlifters participated in this study and were assigned to one of 2 groups: (a) traditional DUP training with a weekly training order: hypertrophy-specific, strength-specific, and power-specific training (HSP, n = 9) or (b) modified DUP training with a weekly training order: hypertrophy-specific, power-specific, and strength-specific training (HPS, n = 9). Both groups trained 3 nonconsecutive days per week for 6 weeks and performed the squat, bench press, and deadlift exercises. During hypertrophy and power sessions, subjects performed a fixed number of sets and repetitions but performed repetitions until failure at a given percentage during strength sessions to compare TV. Testosterone and cortisol were measured at pretesting and posttesting and before each strength-specific day. Hypertrophy, power, and strength produced greater TV in squat and bench press (p ⩽ 0.05) than HSP, but not for deadlift (p > 0.05). For squat and deadlift, there was no difference between groups for 1RM (p > 0.05); however, HPS exhibited greater increases in 1RM bench press than HSP (p ⩽ 0.05). Effect sizes (ES) showed meaningful differences (ES > 0.50) in favor of HPS for squat and bench press 1RM. Testosterone decreased (p ⩽ 0.05) at weeks 5 and 6 and cortisol decline at weeks 3 and 4. However, neither hormone was different at posttesting compared with pretesting (p > 0.05). Our findings suggest that an HPS configuration of DUP has enhanced performance benefits compared with HSP.
CONVULSIVE SYNDROME IN RABBITS INJECTED WITH FAT EMULSION AND HEPARIN

Functionally hepatectomized rabbits showed convulsions and coma within 2 hours after the intravenous injection of fat emulsion and heparin. Intravenous injection of the detergent triton prevented this syndrome, if given before the fat emulsion and heparin, and reversed it if given subsequently. Extremely high plasma non-esterified fatty acid levels were noted in rabbits showing the convulsive syndrome, but not in animals that received the detergent. The mechanism of the convulsions probably includes the toxicity of high amounts of non-esterified fatty acids.
On a theory of media processing systems behavior, with applications

In this article we provide a model for the dynamic behavior of media processing chains of tasks communicating via bounded buffers. The aim is to find the overall behavior of a chain from which performance parameters (such as start time and response time of individual tasks, chain end-to-end response time, number of context switches and resource utilization) follow. This behavior is characterized in terms of the elementary actions of the tasks that make up the chain. From this we derive corollaries that give design guidelines, supporting the goal of improving chain end-to-end response time and the optimization of resources, which is achieved by minimizing context-switching overhead and buffer sizes
Altering Metabolic Profiles of Drugs by Precision Deuteration: Reducing Mechanism-Based Inhibition of CYP2D6 by Paroxetine

Selective deuterium substitution as a means of ameliorating clinically relevant pharmacokinetic drug interactions is demonstrated in this study. Carbon-deuterium bonds are more stable than corresponding carbon-hydrogen bonds. Using a precision deuteration platform, the two hydrogen atoms at the methylenedioxy carbon of paroxetine were substituted with deuterium. The new chemical entity, CTP-347 [(3S,4R)-3-((2,2-dideuterobenzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine], demonstrated similar selectivity for the serotonin receptor, as well as similar neurotransmitter uptake inhibition in an in vitro rat synaptosome model, as unmodified paroxetine. However, human liver microsomes cleared CTP-347 faster than paroxetine as a result of decreased inactivation of CYP2D6. In phase 1 studies, CTP-347 was metabolized more rapidly in humans and exhibited a lower pharmacokinetic accumulation index than paroxetine. These alterations in the metabolism profile resulted in significantly reduced drug-drug interactions between CTP-347 and two other CYP2D6-metabolized drugs: tamoxifen (in vitro) and dextromethorphan (in humans). Our results show that precision deuteration can improve the metabolism profiles of existing pharmacotherapies without affecting their intrinsic pharmacologies.
Lower bound of the number of the Rayleigh resonances for arbitrary body

We study the system of linear elasticity in an exterior domain in R with Neumann boundary conditions. We prove an optimal lower bound for the asymptotic distribution of the resonances near the real axis due to the existence of Rayleigh waves. To this end we construct real quasimodes as the eigenvalues of an elliptic first order ΨDO on the boundary. In case of a convex boundary, we prove that the resonance states are asymptotically close to the quasimode states and we use this to find explicitly the leading term of the resonance states (the Rayleigh waves) on the boundary.
Elevated Circulating Osteoprotegerin and Renal Dysfunction Predict 15-Year Cardiovascular and All-Cause Mortality: A Prospective Study of Elderly Women

Background Data on the predictive role of estimated glomerular filtration rate (eGFR) and osteoprotegerin (OPG) for cardiovascular (CVD) and all-cause mortality risk have been presented by our group and others. We now present data on the interactions between OPG with stage I to III chronic kidney disease (CKD) for all-cause and CVD mortality. Methods and Results The setting was a 15-year study of 1,292 women over 70 years of age initially randomized to a 5-year controlled trial of 1.2 g of calcium daily. Serum OPG and creatinine levels with complete mortality records obtained from the Western Australian Data Linkage System were available. Interactions were detected between OPG levels and eGFR for both CVD and all-cause mortality (P < 0.05). Compared to participants with eGFR ≥60ml/min/1.73m2 and low OPG, participants with eGFR of <60ml/min/1.73m2 and elevated OPG had a 61% and 75% increased risk of all-cause and CVD mortality respectively (multivariate-adjusted HR, 1.61; 95% CI, 1.27-2.05; P < 0.001 and HR, 1.75; 95% CI, 1.22-2.55; P = 0.003). This relationship with mortality was independent of decline in renal function (P<0.05). Specific causes of death in individuals with elevated OPG and stage III CKD highlighted an excess of coronary heart disease, renal failure and chronic obstructive pulmonary disease deaths (P < 0.05). Conclusion The association between elevated OPG levels with CVD and all-cause mortality was more evident in elderly women with poorer renal function. Assessment of OPG in the context of renal function may be important in studies investigating its relationship with all-cause and CVD mortality.
Management of rheumatoid arthritis in People’s Republic of China – focus on tocilizumab and patient considerations

The prevalence of rheumatoid arthritis (RA) is 0.19%–0.41% in Chinese population. RA exerts profound influence on health-related quality of life (HRQoL), which imposed huge burdens on patients physically, mentally, and economically. As a developing country, People’s Republic of China faces enormous challenges in management of RA. Conventional-synthesized disease-modifying antirheumatic drugs (csDMARDs) remain the most selective therapeutic options for RA in People’s Republic of China owing to their affordable price and fair efficacy as well as tolerability. Unfortunately, there are substantial RA patients who are poor responders to csDMARDs, even to subsequently combined therapy with tumor necrosis factor antagonist (anti-TNF). Tocilizumab (TCZ) has been approved as a subsequent-line biological agent in patients with moderate-to-severe RA worldwide including People’s Republic of China. TCZ is the first biological agent approved for the treatment of RA inhibiting interlukin-6 (IL-6) by blocking both membrane-bound and soluble IL-6 receptors. Open-label studies in real-life practice and strictly controlled clinical trials demonstrated its high efficacy and safety profile in treatment of patients with RA who have inadequate responses to csDMARDs and anti-TNF. HRQoL of RA patients was improved in various measurements. TCZ was associated with 1.2 times the risk of adverse events, such as infections, dyslipidemia, and hepatic transaminases elevation, compared with pooled placebo. A relatively long half-life allowing for monthly intravenous administration and a newly developed subcutaneous injection make TCZ more acceptable. However, data are not enough so far comparing TCZ to anti-TNF. Lack of evidence in Chinese patients and high cost of TCZ limit its prescription in People’s Republic of China being a developing country. Further clinical trials and post-marketing surveillance may offer a comprehensive assessment of patient satisfaction and acceptability, which may help us define the optimal role for TCZ in therapeutic strategy.
On Search Based Software Evolution

Writing software is a difficult and expensive task. Its automation is hence very valuable. Search algorithms have been successfully used to tackle many software engineering problems. Unfortunately, for some problems the traditional techniques have been of only limited scope, and search algorithms have not been used yet. We hence propose a novel framework that is based on a co-evolution of programs and test cases to tackle these difficult problems.This framework can be used to tackle software engineering tasks such as Automatic Refinement, Fault Correction,Improving Non-functional Criteria and Reverse Engineering.While the programs evolve to accomplish one of these tasks, test cases are co-evolved at the the same time to find new faults in the evolving programs.
Fertility preservation in patients with early epithelial ovarian cancer.

OBJECTIVE To assess the role of fertility preservation in the treatment of patients with early epithelial ovarian cancer (EOC). METHODS We retrospectively analyzed the medical records of 21 patients with early EOC from January 1995 to December 2006. All eligible patients with a strong desire to preserve fertility were younger than 35 years and underwent fertility-sparing surgery with or without adjuvant chemotherapy. RESULTS Twenty-one eligible patients with a median age of 26.7 years (range, 20 to 33 years) were identified, and the mean follow-up period was 43 months (range, 5 to 86 months). Only one patient with stage IC recurred 34 months after the first operation. A total of five patients were able to become pregnant at least once after the first fertility preserving treatment, with or without adjuvant chemotherapy. All five patients succeeded in full-term vaginal delivery with healthy infants. No patients died of their disease. CONCLUSION Fertility preserving treatment in patients with early EOC can be considered as a proper treatment strategy in patients with early EOC, who have the strong desire for fertility preservation.
Mitochondrial Reactive Oxygen Species Trigger Calcium Increases During Hypoxia in Pulmonary Arterial Myocytes

Abstract— We hypothesized that mitochondria function as the O2 sensors underlying hypoxic pulmonary vasoconstriction by releasing reactive oxygen species (ROS) from complex III of the electron transport chain (ETC). We have previously found that antioxidants or inhibition of the proximal region of the ETC attenuates hypoxic pulmonary vasoconstriction in rat lungs and blocks hypoxia-induced contraction of isolated pulmonary arterial (PA) myocytes. To determine whether the hypoxia-induced increases in mitochondrial ROS act to trigger calcium increases, we measured changes in cytosolic calcium ([Ca2+]i) using fura 2-AM (fluorescence at 340/380 nm) during perfusion with hypoxic media (Po2 12 mm Hg). Hypoxia caused an increase in fura 2 fluorescence, indicating an increase in [Ca2+]i. In superfused PA myocytes, diphenyleneiodonium, rotenone, and myxothiazol, which inhibit the proximal region of the ETC, attenuated hypoxia-induced calcium increases. Antimycin A and cyanide, which inhibit the distal region of the ETC, failed to abolish hypoxia-induced [Ca2+]i increases. To test whether mitochondrial H2O2 is required to trigger [Ca2+]i increases, catalase was overexpressed in PA myocytes with the use of a recombinant adenovirus. Catalase overexpression attenuated hypoxia-induced increases in [Ca2+]i, suggesting that H2O2 acts upstream from calcium increases during hypoxia. These results support the conclusion that mitochondria function as O2 sensors during hypoxia and demonstrate that ROS generated in the proximal region of the ETC act as second messengers to trigger calcium increases in PA myocytes during acute hypoxia.
Two Takeovers in Wild Hamadryas Baboons

Hamadryas baboons exhibit a multi-level social structure in which several onemale units, each consisting of a ‘leader’ male and one or more females, comprise a ‘band’ and two or more bands comprise a troop. Cohesion of each one-male unit is maintained by aggressive herding by its leader male [1]. Here I describe the consequences of 2 takeovers in a band of wild hamadryas baboons. I report evidence of infant mortality following takeovers, changes in female reproductive condition within 2 weeks after takeovers, and the reacquisition of a female by a deposed leader male, none of which has been previously reported for wild hamadryas baboons.