Miracle-dz/UniFAR-FTUs huggingface dataset:
LKB1 Regulates Neuronal Migration and Neuronal Differentiation in the Developing Neocortex through Centrosomal Positioning

The cerebral cortex is formed through the coordination of highly organized cellular processes such as neuronal migration and neuronal maturation. Polarity establishment of neurons and polarized regulation of the neuronal cytoskeleton are essential for these events. Here we find that LKB1, the closest homolog of the Caenorhabditis elegans polarity protein Par4, is expressed in the developing neocortex. Knock-down of LKB1 in migrating immature neurons impairs neuronal migration, with alteration of the centrosomal positioning and with uncoupling between the centrosome and nucleus. Furthermore, impairment of LKB1 in differentiating neurons within the cortical plate induces malpositioning of the centrosome at the basal side of the nucleus, instead of the normal apical positioning. This is accompanied with the disruption of axonal and dendritic polarity, resulting in reversed orientation of differentiating neurons. Moreover, LKB1 specifies axon and dendrites identity in vitro. Together, these observations indicate that LKB1 plays a critical role in neuronal migration and neuronal differentiation. Furthermore, we propose that proper neuronal migration and differentiation are intimately coupled to the precise control of the centrosomal positioning/movement directed by LKB1.
The MyD116 African Swine Fever Virus Homologue Interacts with the Catalytic Subunit of Protein Phosphatase 1 and Activates Its Phosphatase Activity

ABSTRACT The DP71L protein of African swine fever virus (ASFV) shares sequence similarity with the herpes simplex virus ICP34.5 protein over a C-terminal domain. We showed that the catalytic subunit of protein phosphatase 1 (PP1) interacts specifically with the ASFV DP71L protein in a yeast two-hybrid screen. The chimeric full-length DP71L protein, from ASFV strain Badajoz 71 (BA71V), fused to glutathione S-transferase (DP71L-GST) was expressed in Escherichia coli and shown to bind specifically to the PP1-α catalytic subunit expressed as a histidine fusion protein (6×His-PP1α) in E. coli. The functional effects of this interaction were investigated by measuring the levels of PP1 and PP2A in ASFV-infected Vero cells. This showed that infection with wild-type ASFV strain BA71V activated PP1 between two- and threefold over that of mock-infected cells. This activation did not occur in cells infected with the BA71V isolate in which the DP71L gene had been deleted, suggesting that expression of DP71L leads to PP1 activation. In contrast, no effect was observed on the activity of PP2A following ASFV infection. We showed that infection of cells with wild-type BA71V virus resulted in decreased phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF-2α). ICP34.5 recruits PP1 to dephosphorylate the α subunit of eukaryotic translational initiation factor 2 (also known as eIF-2α); possibly the ASFV DP71L protein has a similar function.
Comorbidity and Suicidality in Patients Diagnosed with Panic Disorder/Agoraphobia and Major Depression.

BACKGROUND Comorbidity of anxiety and depression (both current and lifetime) is associated with greater chronicity and an increased risk of suicidality. We wished to ascertain which symptom clusters had the strongest association with suicidality. Our aims were (1) to examine the presence of current comorbidity and suicidality in patients diagnosed with panic disorder/agoraphobia (PD/A) and major depression (MD), and their relationship with duration of psychiatric treatment and frequency of hospital admission; and (2) to examine which coexisting symptoms were most strongly predictive of suicidality in sub-groups and the overall group. SUBJECTS AND METHODS The study sample comprised 100 patients with PD/A and MD. The following assessment instruments were applied: the Panic and Agoraphobia Scale, the Beck Anxiety Inventory, the Beck Depression Inventory-II, the Beck Scale for Suicide Ideation, the Obsessive-Compulsive Inventory-Revised, the Liebowitz Social Anxiety Scale and the Whiteley Index of Hypochondriasis. RESULTS High rates of current comorbidity were seen in both groups. Patients with MD had significantly higher suicidality scores, but were also older, with a longer duration of psychiatric treatment and more frequent hospitalizations. In the overall group, psychiatric comorbidity was correlated with duration of psychiatric treatment and frequency of hospitalizations (with the exception of hypochondriasis which was not correlated with frequency of hospitalization). In both sub-groups and the overall group, suicidality was correlated with scores for all examined comorbidity (with the exception of hypochondriasis in the PD/A group): however, after multiple regression only obsessive-compulsive symptomatology predicted suicidality in all sub-groups and the overall group, as well as depression in the overall group. Depression supposed as dependent variable and obsessive-compulsive symptomatology as a mediator explained around 37% of the variance in suicidal ideation. CONCLUSION Patients with PD/A or MD show high rates of current comorbidity. The effect of depression on suicidality was significant, but a non-trivial impact was also mediated by obsessive-compulsive symptomatology.
IMS at the CoNLL 2017 UD Shared Task: CRFs and Perceptrons Meet Neural Networks

This paper presents the IMS contribution to the CoNLL 2017 Shared Task. In the preprocessing step we employed a CRF POS/morphological tagger and a neural tagger predicting supertags. On some languages, we also applied word segmentation with the CRF tagger and sentence segmentation with a perceptron-based parser. For parsing we took an ensemble approach by blending multiple instances of three parsers with very different architectures. Our system achieved the third place overall and the second place for the surprise languages.
Exploring international clinical education in US-based programs: identifying common practices and modifying an existing conceptual model of international service-learning

Abstract Background: Increasingly physical therapist students complete part of their clinical training outside of their home country. This trend is understudied. The purposes of this study were to: (1) explore, in depth, various international clinical education (ICE) programs; and (2) determine whether the Conceptual Model of Optimal International Service-Learning (ISL) could be applied or adapted to represent ICE. Methods: Qualitative content analysis was used to analyze ICE programs and consider modification of an existing ISL conceptual model for ICE. Fifteen faculty in the United States currently involved in ICE were interviewed. The interview transcriptions were systematically analyzed by two researchers. Results: Three models of ICE practices emerged: (1) a traditional clinical education model where local clinical instructors (CIs) focus on the development of clinical skills; (2) a global health model where US-based CIs provide the supervision in the international setting, and learning outcomes emphasized global health and cultural competency; and (3) an ICE/ISL hybrid where US-based CIs supervise the students, and the foci includes community service. Additionally the data supported revising the ISL model’s essential core conditions, components and consequence for ICE. Conclusions: The ICE conceptual model may provide a useful framework for future ICE program development and research.
Hearts transplanted after circulatory death in children: Analysis of the International Society for Heart and Lung Transplantation registry

We aimed to describe worldwide DCD HT experience in children using the International Society for Heart and Lung Transplantation Registry. The Registry was queried for primary HT performed in children (2005‐2014). Kaplan‐Meier analysis was used to assess survival for recipients grouped by DCD or DBD hearts. Recipient characteristics were compared between DCD and DBD and between survivors and non‐survivors of DCD HT. Among 3877 pediatric HT performed, 21 (0.5%) were DCD. DCD 1‐year survival was 61% vs 91% DBD, P < . 01. DCD recipients were more often supported by ECMO pre‐HT (24% vs 6%, P < .001) and more often receiving inhaled nitric oxide (10% vs 0.6%, P < .001) compared to DBD. Older DCD recipients had significantly lower 1‐year survival of 57% vs 93% for DBD, P < . 01. Survival for infant DCD recipients was not statistically different to DBD recipients (survival 62% at 1 year and 62% at 5 years for DCD vs 85% at 1 year and 77% at 5 years for DBD, P = .15). Recipients of DCD HT who died were more often supported by ECMO pre‐HT (56% non‐survivors vs 0% survivors, P = .004) and receiving mechanical ventilation (44% vs 0%, P = .012). DCD HT is uncommon in children. DCD‐independent factors in recipients may have contributed to worse survival as DCD recipients who died were more often supported by ECMO and mechanical ventilation. More research is needed to identify donor factors and recipient factors that contribute to mortality after DCD HT.
Testing the Keynesian Proposition of Twin Deficits in the Presence of Trade Liberalisation: Evidence from Sri Lanka after War: the case of a bridge too far?

This paper examines the long-run and short-run relationships between the current account deficit, budget deficit, savings and investment gap and trade openness in Sri Lanka using the autoregressive distributive lagged (ARDL) approach. The time series properties of the variables, in the presence of endogenous structural breaks, was previously analysed using Perron’s (1997) additive outlier (AO) and innovational outlier (IO) models. The empirical analysis supports the Keynesian view that a link exists between the current account, budget deficit and savings and investment gap. We found that trade openness has a positive effect on the current account deficit, but is statistically insignificant, and offer some strategies to stabilise the budget deficit and current account deficits in Sri Lanka.
Motivation and good language learners

It almost goes without saying that good language learners are motivated. Common sense and everyday experience suggest that the high achievers of this world have motivation, a word which derives from the Latin verb movere meaning to move. Thus, simply defined, we might say that motivation concerns what moves a person to make certain choices, to engage in action, and to persist in action. The need for personal motivation is a message that resonates across so many stories of major and minor human endeavor, whether in the single-minded dedication of an athlete pursuing an Olympic dream, the drive and ambition of a young executive aiming for the top of the corporate ladder, or the willpower and self-discipline of someone determined to lose weight or to give up smoking. Without motivation, success will be hard to come by, and the case of learning a second or foreign language is little different. Motivation is listed by Rubin (1975) among the three essential variables on which good language learning depends. As Corder (1967, p. 164) famously put it forty years ago, “Let us say that, given motivation, it is inevitable that a human being will learn a second language if he is exposed to the language data. ” Yet however commonsensical this general observation might be, the pursuit of its empirical verification has exercised language acquisition scholars for decades and generated an enormous amount of research.
APOE genotype and early β-amyloid accumulation in older adults without dementia

Objective: To clarify associations between APOE ε4 allele and age on longitudinal rates of β-amyloid (Aβ) accumulation within Aβ+ and Aβ− older individuals without dementia. Methods: We analyzed 595 older adults without dementia classified cross-sectionally as Aβ− (n = 325) and Aβ+ (n = 270) using longitudinal florbetapir PET. The influence of age and APOE genotype on longitudinal accumulation of Aβ was examined with linear mixed models. Results: APOE ε4 and older age were associated with higher risk of being classified as Aβ+ at baseline. The annual rate of Aβ accumulation was significantly greater than zero for Aβ− ε3 (0.0021 ± 0.0007 standardized uptake value ratio [SUVR] units) and Aβ− ε4 (0.0044 ± 0.0010 SUVR units), as well as Aβ+ ε3 (0.0141 ± 0.0019 SUVR units) and Aβ+ ε4 (0.0126 ± 0.0018 SUVR units). Aβ accumulation was significantly faster in Aβ− ε4 compared to Aβ− ε3 and Aβ− ε2. Rates of Aβ accumulation did not differ significantly between Aβ+ APOE groups. Older age was associated with higher rates of Aβ accumulation in the Aβ− group. Conclusions: APOE ε4 carriage and older age were predictors of longitudinal Aβ accumulation within the Aβ− group but not the Aβ+ group. APOE ε2 carriage was protective against longitudinal Aβ accumulation within the Aβ− group. APOE genotype in conjunction with chronologic age may aid in participant selection for primary prevention trials aimed at halting Aβ accumulation before abnormal levels are reached.
European Conference on Information Systems ( ECIS ) 5-15-2012 ORGANIZATIONAL ADOPTION OF INNOVATION : IDENTIFYING FACTORS THAT INFLUENCE RFID ADOPTION IN THE HEALTHCARE INDUSTRY

In this paper, we endeavor to make two specific contributions to research on the adoption of innovations. First, we propose a typology of innovations and suggest that theory-driven adoption research should strive to match innovation types with theories that have related explanatory emphases. We propose this overarching framework for innovation adoption research because different innovations have different characteristics, and thus, it seems unlikely that a single theoretical explanation can be developed to describe the adoption and diffusion of all types of innovations. Second, we develop a model that identifies the factors that influence the adoption of one particular type of innovation: RFID. Our research model is built upon the Technology – Organization – Environment (TOE) theoretical framework, and is tested using PLS on a dataset of US firms (N = 168). We also highlight an interesting empirical result that indicates that while researchers have generally argued that dissatisfaction with existing information systems drives adoption of new systems, in some cases it is satisfaction that drives the adoption of new systems.
The Emotional Lexicon and Its Correlates Following Traumatic Brain Injury

Traumatic brain injury (TBI) can often influence the way subjects process and cope with their emotional life. In spite of the huge amount of studies investigating facial emotion recognition in subjects with traumatic brain injury, none of them has examined if their emotional lexicon, i.e. the ability to express emotions through words, may be affected. In this case-control study, we investigated the emotional lexicon of a group of 16 severe TBI subjects, comparing their performances with an healthy control group. A set of 25 visual stimuli (10 single picture images, 5 cartoon story pictures and 10 video clips) were selected. All the stimuli were chosen for their high emotional content by ten blind judges. The participants were asked to describe the stimuli, focusing on their emotional content. To get a better understanding of the correlates of emotional lexicon, all the participants were administered with the backward version of the Digit Span test, the Ekman and Friesen 60 Faces, the 20-Item Toronto Alexithymia Scale and the Empathy Quotient. Results pointed out a significant difference between TBI subjects and healthy controls only for cartoon story and video clip description. Conversely, TBI subjects performed similarly to controls when asked to describe the single picture images. A significant correlation was found in TBI subjects between the results of the Digit Span and number of emotional words, while no correlation was detected between emotional terms and the three scales used to assess TBI subjects’ emotional profile. These outcomes highlight that, for more complex stimuli, difficulties in emotional lexicon may depend on factors other than empathy, alexythimia or emotion recognition. These difficulties seem to be related to reduced working memory capacity, which prevent the subjects from correctly processing the emotional content of stimuli.
Social Dominance Theory

Social dominance theory is a multi-level theory of how societies maintain group-based dominance. Nearly all stable societies can be considered group-based dominance hierarchies, in which one social group – often an ethnic, religious, national, or racial one – holds disproportionate power and enjoys special privileges, and at least one other group has relatively little political power or ease in its way of life. As examples, consider the relationship between contemporary Western European nations and their immigrant groups and Roma, between the ruling elites of South America and their indigenous peoples, or between Jewish Israelis and Palestinians. In all cases, the economic, educational, and health outcomes are superior for members of the dominant groups from what they are for members of the subordinate groups. Moreover, societies recognize the legal rights of dominants and portray their ways of living as virtuous and characteristic of the whole society, whereas subordinates receive little social recognition and are even stigmatized. Group dominance societies also feature an intersecting kind of group oppression, namely sexism, men holding disproportionate power and freedoms compared with women, and heterosexism being privileged over other kinds of sexuality. Social dominance theory describes how processes at different levels of social organization, from cultural ideologies and institutional discrimination to gender roles and the psychology of prejudice, work together to produce stable group-based inequality. Keywords: force; oppression; social justice; legitimizing myths; group dominance; violence
Transplanted Endothelial Progenitor Cells Improve Ischemia Muscle Regeneration in Mice by Diffusion Tensor MR Imaging

Endothelial progenitor cells (EPCs) play an important role in repairing ischemia tissues. Diffusion tensor imaging (DTI) was applied to detect the architectural organization of skeletal muscle. This study investigated the feasibility and accuracy of using the DTI to evaluate effectiveness of EPCs treatment. Mouse bone marrow-derived EPCs were isolated, cultured, characterized, and transplanted to hindlimb ischemia mice model. DTI was performed on the hindlimb at postischemia time points. The edema regions of diffusion restriction (high signal in diffusion weighted imaging) were decreased in the ischemic muscle of EPCs treated mice after 14 days compared with the controls. These results from DTI show the lower apparent diffusion coefficient and eigenvalues (λ1, λ2, and λ3) and the higher fractional anisotropy and fiber counts of ischemic muscle on 7 and 14 days after EPCs treatment compared to the controls. There was a significant correlation between fiber counts calculated by DTI and survival fibers evaluated by histological section (r = 0.873, P < 0.01). Our study demonstrated that the time frame for muscle fiber regeneration after EPCs transplantation was significantly shortened in vivo. DTI could be a useful tool for noninvasive evaluation of muscle tissue damage and repair in animal models and patient with ischemic diseases.
Counseling adults in transition : linking Schlossberg's theory with practice in a diverse world

The only textbook explicitly designed to address counseling with adults who are coping with individual, relationship, and work transitions, this volume integrates the basic tenets of adult development with therapeutic practice. It is based on Schlossberg's theory of transitions, a new process and content model that offers effective techniques for helping adults to understand and successfully navigate normal life transitions. This revised edition addresses contemporary societal ills that exacerbate adult life transitions, such as a tumultuous economy, increased unemployment, bankruptcies, and foreclosures, and focuses on our increasing racial and cultural diversity. The volume also expands its consideration of spiritual and social justice issues and provides a more integrated and holistic approach to adult transitional counseling. Key Features of the New Edition: Based on Schlossberg's technique, a new model for counseling adults in transition Offers practical new strategies and exercises for use in transitional counseling Addresses unemployment and coping in an uncertain social/economic context Focuses on loss and resilience, diversity, culture, social justice, and spirituality Contains new sections on transitioning to adulthood, living arrangements including diverse family structures, mobility, siblings, in-laws, and retirement Introduces new concepts such as collectivist coping, hardiness, mindfulness, and transcendence
Aluminum-activated root malate and citrate exudation is independent of NIP1;2-facilitated root-cell-wall aluminum removal in Arabidopsis

ABSTRACT In Arabidopsis, aluminum (Al) exclusion from the root is mainly facilitated by Al-activated root malate and citrate exudation through the ALMT1 malate transporter and the MATE citrate transporter, respectively. However, the nature of an internal Al tolerance mechanism remains largely unknown. In a recent study, we showed that NIP1;2 facilitates Al-malate transport from the root cell wall into the root symplasm and subsequent root-to-shoot translocation and thus NIP1;2 plays key roles in Al detoxification and internal tolerance in Arabidopsis. We discovered that the NIP1;2-mediated Al removal from the root cell wall requires a functional ALMT1-mediated malate exudation system, which allows the formation of an Al-malate complex in the root cell wall. Thus, a coordinated function between the exclusion and the internal resistance mechanisms, linked by the ALMT1-mediated root malate exudation and the NIP1;2-mediated Al uptake system, is critical for Al resistance in Arabidopsis.
Origins and Development of Morality

Origins and Development of Morality Morality is a central aspect of social life and has been at the core of psychological theories for more than a century. The scientific study of morality poses enduring questions about how individual psychological needs for autonomy and attachment to groups and society can be met while also ensuring the integrity, dignity, and fair treatment of others. Drawing on philosophy, biology, anthropology, and sociology, developmental scientists have addressed these questions by studying the origins and acquisition of morality as well as the sources and nature of change. We provide a brief review of the theories that provided the foundation for research over the past half-century and then reflect on the controversies and misconceptions that still exist. We review current psychological research on the developmental roots of morality, morality and mental state knowledge, and moral judgments and reasoning. We also examine the various contexts, ranging from the family and peer groups to society, in which moral development occurs. The rich and growing literature on children's moral judgments has demonstrated that children's concepts of harm, resource allocation, fair and equal treatment of others, social inequities, and rights each develop from a very focused and narrow form in early childhood to their application to broader situational and cultural contexts. As they grow older, children become able to weigh and coordinate competing concerns in different contexts as they apply their moral judgments and emotions to social situations. We conclude with implications and directions for research. Throughout the chapter, we demonstrate how the study of morality has shed light on fundamental topics in developmental science, contributed novel methods, and discovered new knowledge about child development. Keywords: equality; discrimination; fairness; family relationships; intergroup attitudes; justice; moral emotions; moral judgments; moral neuroscience; morality; peer interactions; prejudice; rights; theory of mind