Miracle-dz/UniFAR-FTUs huggingface dataset:
An Ultrasound System for Local Hyperthermia Using Scanned Focused Transducers

A computer simulation of tissue heating is used to examine the heating pattern produced by a focused ultrasound transducer scanned over the tumor. It is shown that, a large area transducer is required to give preferential heating at depth and the heating pattern is not given by the path of the focal volume. The effect of varying the heating pattern with time by pulsing or scanning is investigated using an estimate of thermal dose which takes into account the. nonlinear dependence of heat damage on temperature, and it is found that temperature fluctuations tend to reduce the therapeutic ratio and so should be avoided. The implications of these results on the design of ultrasound heating systems are discussed.
Implant retention in a rabbit model of fracture-related infection

Aims Fracture-related infection (FRI) is commonly classified based on the time of onset of symptoms. Early infections (< two weeks) are treated with debridement, antibiotics, and implant retention (DAIR). For late infections (> ten weeks), guidelines recommend implant removal due to tolerant biofilms. For delayed infections (two to ten weeks), recommendations are unclear. In this study we compared infection clearance and bone healing in early and delayed FRI treated with DAIR in a rabbit model. Methods Staphylococcus aureus was inoculated into a humeral osteotomy in 17 rabbits after plate osteosynthesis. Infection developed for one week (early group, n = 6) or four weeks (delayed group, n = 6) before DAIR (systemic antibiotics: two weeks, nafcillin + rifampin; four weeks, levofloxacin + rifampin). A control group (n = 5) received revision surgery after four weeks without antibiotics. Bacteriology of humerus, soft-tissue, and implants was performed seven weeks after revision surgery. Bone healing was assessed using a modified radiological union scale in tibial fractures (mRUST). Results Greater bacterial burden in the early group compared to the delayed and control groups at revision surgery indicates a retraction of the infection from one to four weeks. Infection was cleared in all animals in the early and delayed groups at euthanasia, but not in the control group. Osteotomies healed in the early group, but bone healing was significantly compromised in the delayed and control groups. Conclusion The duration of the infection from one to four weeks does not impact the success of infection clearance in this model. Bone healing, however, is impaired as the duration of the infection increases. Cite this article: Bone Joint Res 2024;13(3):127–135.
Power and performance of read-write aware Hybrid Caches with non-volatile memories

Caches made of non-volatile memory technologies, such as Magnetic RAM (MRAM) and Phase-change RAM (PRAM), offer dramatically different power-performance characteristics when compared with SRAM-based caches, particularly in the areas of static/dynamic power consumption, read and write access latency and cell density. In this paper, we propose to take advantage of the best characteristics that each technology has to offer through the use of read-write aware Hybrid Cache Architecture (RWHCA) designs, where a single level of cache can be partitioned into read and write regions, each of a different memory technology with disparate read and write characteristics. We explore the potential of hardware support for intra-cache data movement within RWHCA caches. Utilizing a full-system simulator that has been validated against real hardware, we demonstrate that a RWHCA design with a conservative setup can provide a geometric mean 55% power reduction and yet 5% IPC improvement over a baseline SRAM cache design across a collection of 30 workloads. Furthermore, a 2-layer 3D cache stack (3DRWHCA) of high density memory technology with the same chip footprint still gives 10% power reduction and boost performance by 16% IPC improvement over the baseline.
Journal of Neuroengineering and Rehabilitation Open Access Advances in Wearable Technology and Applications in Physical Medicine and Rehabilitation the Potential Impact of Wearable Technology on Physical Medicine and Rehabilitation

The development of miniature sensors that can be unobtrusively attached to the body or can be part of clothing items, such as sensing elements embedded in the fabric of garments, have opened countless possibilities of monitoring patients in the field over extended periods of time. This is of particular relevance to the practice of physical medicine and rehabilitation. Wearable technology addresses a major question in the management of patients undergoing rehabilitation, i.e. have clinical interventions a significant impact on the real life of patients? Wearable technology allows clinicians to gather data where it matters the most to answer this question, i.e. the home and community settings. Direct observations concerning the impact of clinical interventions on mobility, level of independence, and quality of life can be performed by means of wearable systems. Researchers have focused on three main areas of work to develop tools of clinical interest: 1)the design and implementation of sensors that are minimally obtrusive and reliably record movement or physiological signals, 2)the development of systems that unobtrusively gather data from multiple wearable sensors and deliver this information to clinicians in the way that is most appropriate for each application, and 3)the design and implementation of algorithms to extract clinically relevant information from data recorded using wearable technology. Journal of NeuroEngineering and Rehabilitation has devoted a series of articles to this topic with the objective of offering a description of the state of the art in this research field and pointing to emerging applications that are relevant to the clinical practice in physical medicine and rehabilitation. Understanding the impact of clinical interventions on the real life of individuals is an essential component of physical medicine and rehabilitation. While assessments performed in the clinical setting have value, it is difficult to perform thorough, costly evaluations of impairment and functional limitation within the time constraints and limited resources available in outpatient units of rehabilitation hospitals. Furthermore, it is often questioned whether assessments performed in the clinical setting are truly representative of how a given clinical intervention affects the real life of patients. While this observation has fostered a great deal of interest for the development and validation of outcome measures that largely rely on the use of questionnaires [1], researchers and clinicians have looked at recent advances in wearable technology intrigued by the possibility offered by this technology of gathering sensor data in the field [2,3]. Likely to be complementary to …
Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins.

OBJECTIVE To determine whether hypoxia and hypoxia-inducible factor (HIF) proteins regulate expression of β-1,3-glucuronyltransferase 1 (GlcAT-1), a key enzyme in glycosaminoglycan synthesis in nucleus pulposus cells. METHODS Real-time reverse transcriptase-polymerase chain reaction and Western blotting were used to measure GlcAT-1 expression. Transfections were performed to determine the effect of HIF-1α and HIF-2α on GlcAT-1 promoter activity. RESULTS Under hypoxic conditions there was an increase in GlcAT-1 expression; a significant increase in promoter activity was seen both in nucleus pulposus cells and in N1511 chondrocytes. We investigated whether HIF controlled GlcAT-1 expression. Suppression of HIF-1α and HIF-2α induced GlcAT-1 promoter activity and expression only in nucleus pulposus cells. Transfection with CA-HIF-1α as well as with CA-HIF-2α suppressed GlcAT-1 promoter activity only in nucleus pulposus cells, suggesting a cell type-specific regulation. Site-directed mutagenesis and deletion constructs were used to further confirm the suppressive effect of HIFs on GlcAT-1 promoter function in nucleus pulposus cells. Although it was evident that interaction of HIF with hypoxia-responsive elements resulted in suppression of basal promoter activity, it was not necessary for transcriptional suppression. This result suggested both a direct and an indirect mode of regulation, possibly through recruitment of a HIF-dependent repressor. Finally, we showed that hypoxic expression of GlcAT-1 was also partially dependent on MAPK signaling. CONCLUSION These studies demonstrate that hypoxia regulates GlcAT-1 expression through a signaling network comprising both activator and suppressor molecules, and that this regulation is unique to nucleus pulposus cells.
Interval Type-2 Fuzzy Sets are Generalization of Interval-Valued Fuzzy Sets: Toward a Wider View on Their Relationship

In this paper, we will present a wider view on the relationship between interval-valued fuzzy sets and interval type-2 fuzzy sets, where we will show that interval-valued fuzzy sets are a particular case of the interval type-2 fuzzy sets. For this reason, both concepts should be treated in a different way. In addition, the view presented in this paper will allow a more general perspective of interval type-2 fuzzy sets, which will allow representing concepts that could not be presented by interval-valued fuzzy sets.
[Helicopter emergency medical services for patients with cerebral stroke].

OBJECTIVES The aim of this cross-sectional study was to analyze transport by helicopter emergency medical services (HEMS) in cases of ischemic cerebral stroke in Poland in 2011 and 2012. We assessed the role of the HEMS in reducing prehospital times and analyzed changes in patients' status during transport. MATERIAL AND METHODS Retrospective study of all missions flown by the Polish HEMS to attend stroke patients over the 2-year period. The following data were collected for each mission and patient: time from activation of the HEMS until arrival at the scene, time spent at the scene; and scores on the National Advisory Committee for Aeronautics scale, the Revised Trauma Scale (ETR), and the Glasgow Coma Scale (ECG) at the scene and on transfer of the patient to the hospital or ambulance. RESULTS A total of 1191 patients were analyzed. The mean (SD) ETR and ECG scores on the scene were 11.1 (1.36) and 11.8 (3.39), respectively. After HEMS transport the means were 11.0 (1.5) and 11.7 (3.5). In-flight transport did not affect the patient's condition, but more time spent at the scene was associated with significantly lower scores on the scales. CONCLUSION Helicopter transport of these patients is safe and ensures their transfer to the nearest hospital or ambulance within the treatment time window. Time spent on care at the scene of the emergency should probably be as short as possible.
A Petri Net Model for FDDI

A Petri Net Model for FDDI N. Sergent Fiber Distributed Data Interface (FDDI) is a high speed local area network operating at 100Mbps using a fiber optic ring transmission medium. The purpose of this paper is to build a Petri net model for the FDDI media access control (MAC) protocol. This model is hierarchically integrated into the Petri net model of the two-phase commitment (2PC) algorithm. By simulating the composed Petri net model we evaluate the latency of the 2PC algorithm. The FDDI model is validated by comparing the data obtained from performance measures and the numerical results derived from simulation.
Strategies to Mitigate Age-Related Bias in Machine Learning: Scoping Review.

BACKGROUND Research suggests that digital ageism, that is, age-related bias, is present in the development and deployment of machine learning (ML) models. Despite the recognition of the importance of this problem, there is a lack of research that specifically examines the strategies used to mitigate age-related bias in ML models and the effectiveness of these strategies. OBJECTIVE To address this gap, we conducted a scoping review of mitigation strategies to reduce age-related bias in ML. METHODS We followed a scoping review methodology framework developed by Arksey and O'Malley. The search was developed in conjunction with an information specialist and conducted in 6 electronic databases (IEEE Xplore, Scopus, Web of Science, CINAHL, EMBASE, and the ACM digital library), as well as 2 additional gray literature databases (OpenGrey and Grey Literature Report). RESULTS We identified 8 publications that attempted to mitigate age-related bias in ML approaches. Age-related bias was introduced primarily due to a lack of representation of older adults in the data. Efforts to mitigate bias were categorized into one of three approaches: (1) creating a more balanced data set, (2) augmenting and supplementing their data, and (3) modifying the algorithm directly to achieve a more balanced result. CONCLUSIONS Identifying and mitigating related biases in ML models is critical to fostering fairness, equity, inclusion, and social benefits. Our analysis underscores the ongoing need for rigorous research and the development of effective mitigation approaches to address digital ageism, ensuring that ML systems are used in a way that upholds the interests of all individuals. TRIAL REGISTRATION Open Science Framework AMG5P; https://osf.io/amg5p.
Looking forward to a general theory on population aging.

The main theories on population aging based on recent data on human longevity, life expectancy, morbidity changes, disability trends, and mortality decrease are presented and discussed within their own geographic, cultural, socioeconomic, and medical contexts. The complex interactions between all these components do not facilitate trend forecasting of aging population (healthy aging versus disability pandemic). In the context of population aging, four elements were introduced with their implications: 1) an increase in the survival rates of sick persons, which would explain the expansion of morbidity, 2) a control of the progression of chronic diseases, which would explain a subtle equilibrium between the decrease in mortality and the increase in disability, 3) an improvement of the health status and health behaviors of new cohorts of elderly people, which would explain the compression of morbidity, and eventually 4) an emergence of very old and frail populations, which would explain a new expansion of morbidity. Obviously, all these elements coexist today, and future trend scenarios-expansion or compression of disability-depend on their respective weights leading to the need of elaborating "a general theory on population aging. " This theory has to be based on a world harmonization of functional decline measurements and a periodic "International Aging Survey" to monitor global aging through a sample of carefully selected countries.
The Protective Effects of Astaxanthin on the OVA-Induced Asthma Mice Model

Although astaxanthin has a variety of biological activities such as anti-oxidant effects, inhibitory effects on skin deterioration and anti-inflammatory effects, its effect on asthma has not been studied. In this paper, the inhibitory effect of astaxanthin on airway inflammation in a mouse model of ovalbumin (OVA)-induced asthma was investigated. We evaluated the number of total cells, Th1/2 mediated inflammatory cytokines in bronchoalveolar lavage fluid (BALF) and airway hyperresponsiveness as well as histological structure. The level of total IgE, IgG1, IgG2a, OVA-specific IgG1, and OVA-specific IgG2a were also examined. The oral administration of 50 mg/mL astaxanthin inhibited the respiratory system resistance, elastance, newtonian resistance, tissue damping, and tissue elastance. Also, astaxanthin suppressed the total cell number, IL-4, and IL-5, and increased the IFN-γ in the BALF. In the sera, total IgE, IgG1, and OVA-specific IgG1 were reduced by astaxanthin exposure and IgG2a and OVA-specific IgG2a were enhanced via oral administration of astaxanthin. Infiltration of inflammatory cells in the lung, production of mucus, lung fibrosis, and expression of caspase-1 or caspase-3 were suppressed in OVA-induced asthmatic animal treated with astaxanthin. These results suggest that astaxanthin may have therapeutic potential for treating asthma via inhibiting Th2-mediated cytokine and enhancing Th1-mediated cytokine.
Nitrogen assimilation and transpiration: key processes conditioning responsiveness of wheat to elevated [CO2] and temperature.

Although climate scenarios have predicted an increase in [CO(2)] and temperature conditions, to date few experiments have focused on the interaction of [CO(2)] and temperature effects in wheat development. Recent evidence suggests that photosynthetic acclimation is linked to the photorespiration and N assimilation inhibition of plants exposed to elevated CO(2). The main goal of this study was to analyze the effect of interacting [CO(2)] and temperature on leaf photorespiration, C/N metabolism and N transport in wheat plants exposed to elevated [CO(2)] and temperature conditions. For this purpose, wheat plants were exposed to elevated [CO(2)] (400 vs 700 µmol mol(-1)) and temperature (ambient vs ambient + 4°C) in CO(2) gradient greenhouses during the entire life cycle. Although at the agronomic level, elevated temperature had no effect on plant biomass, physiological analyses revealed that combined elevated [CO(2)] and temperature negatively affected photosynthetic performance. The limited energy levels resulting from the reduced respiratory and photorespiration rates of such plants were apparently inadequate to sustain nitrate reductase activity. Inhibited N assimilation was associated with a strong reduction in amino acid content, conditioned leaf soluble protein content and constrained leaf N status. Therefore, the plant response to elevated [CO(2)] and elevated temperature resulted in photosynthetic acclimation. The reduction in transpiration rates induced limitations in nutrient transport in leaves of plants exposed to elevated [CO(2)] and temperature, led to mineral depletion and therefore contributed to the inhibition of photosynthetic activity.
Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct

The oviduct is an important organ in reproduction where fertilization occurs, and through which the fertilized eggs are carried to the uterus in mammals. This organ is highly polarized, where the epithelium forms longitudinal folds along the ovary-uterus axis, and the epithelial multicilia beat towards the uterus to transport the ovulated ova. Here, we analyzed the postnatal development of mouse oviduct and report that multilevel polarities of the oviduct are regulated by a planar cell polarity (PCP) gene, Celsr1. In the epithelium, Celsr1 is concentrated in the specific cellular boundaries perpendicular to the ovary-uterus axis from postnatal day 2. We found a new feature of cellular polarity in the oviduct – the apical surface of epithelial cells is elongated along the ovary-uterus axis. In Celsr1-deficient mice, the ciliary motion is not orchestrated along the ovary-uterus axis and the transport ability of beating cilia is impaired. Epithelial cells show less elongation and randomized orientation, and epithelial folds show randomized directionality and ectopic branches in the mutant. Our mosaic analysis suggests that the geometry of epithelial cells is primarily regulated by Celsr1 and as a consequence the epithelial folds are aligned. Taken together, we reveal the characteristics of the multilevel polarity formation processes in the mouse oviduct epithelium and suggest a novel function of the PCP pathway for proper tissue morphogenesis.
A 76.2–89.1 GHz Phase-Locked Loop With 15.6% Tuning Range in 90 nm CMOS for W-Band Applications

In this letter, a wide tuning range W-band phase-locked loop (PLL) in 90 nm CMOS is presented. A novel frequency tripling topology with a single cross-coupled pair and a dual tank is proposed for the voltage-controlled oscillator (VCO) to achieve wide tuning characteristics under low power consumption. The locking range of the PLL at the fundamental tone is 25.4-29.7 GHz, and an excellent tuning range at the third harmonic frequency up to 12.9 GHz (from 76.2 to 89.1 GHz, 15.6%) is obtained. Under a 1.2 V supply voltage (Pdiss = 62.4 mW), the measured closed-loop phase noise of the PLL is -83.5 dBc/Hz at 78.34 GHz. To the best of our knowledge, the achieved turning range is the highest currently reported for the PLLs operating in a similar frequency range in CMOS technology.
Stokes‐Einstein relation in liquid iron‐nickel alloy up to 300 GPa

Molecular dynamic simulations were applied to investigate the Stokes‐Einstein relation (SER) and the Rosenfeld entropy scaling law (ESL) in liquid Fe0.9Ni0. 1 over a sufficiently broad range of temperatures (0.70 < T/Tm < 1.85; Tm is melting temperature) and pressures (from 50 GPa to 300 GPa). Our results suggest that the SER and ESL hold well in the normal liquid region and break down in the supercooled region under high‐pressure conditions, and the deviation becomes larger with decreasing temperature. In other words, the SER can be used to calculate the viscosity of liquid Earth's outer core from the self‐diffusion coefficients of iron/nickel and the ESL can be used to predict the viscosity and diffusion coefficients of liquid Earth's outer core form its structural properties. In addition, the pressure dependence of effective diameters cannot be ignored in the course of using the SER. Moreover, ESL provides a useful, structure‐based probe for the validity of SER, while the ratio of the self‐diffusion coefficients of the components cannot be used as a probe for the validity of SER.
GEOPHYSICAL INVESTIGATION ON THE FRACTURE DISTRIBUTION OF IWO-OLUPONA AREA SOUTH-WESTERN NIGERIA USING VLF-EM TECHNIQUES

This work uses Very Low Frequency Electromagnetic (VLF-EM) method to investigate the subsurface structure on a proposed Housing estate in Iwo, South-Western Nigeria with coordinates 7° 36’ 36.3” N and Longitude ≈ 4° 12’ 06.6” E. The average VLF frequency employed during the field work is 20.8 kHz with average signal strength of 17dBm and the measuring interval of 20m. The data obtained by the VLF-EM method were analysed by 2Dline Plotting. Raw real, R (In phase) and the imagining, I (quadrature) components were measured on the field. The Raw Real and filtered real data were plotted against stations on the same graph using excel, the graphs obtained are sinusoidal in shape with the peak indicating a conductive zones, resulting from weak geologic materials that may be due to fracture, joints, crack, and the trough indicates a non-conductive zones, associated with competent material which may be attributed to fresh basement material or resistive geological formation. Keywords: Fracture, conductive zone, weak zone, structural displacement, frequency