Evaluation of Some Fibrinolytic Factors for Assessment of Lower Extremity Arterial Disease ( LEAD ) in Diabetic Patients

This study was carried out in the Clinical Pathology and Internal Medicine Departments, Faculty of Medicine, Zagazig University Hospitals. The study included 57 subjects classified into 3 groups. Group I: It included 13 apparently healthy subjects. Group II: It included 22 insulin-dependent diabetic patients. They were sub-classified into 15 NON Lower Extremity Arterial Disease (LEAD) and 7 LEAD. Group III: It included 22 noninsulin-dependent diabetic patients. They were sub-classified into 15 NON LEAD and 7 LEAD. All patients and control subjects were subjected to the followings: 1Full history taking. 2-Complete clinical examination 3Complete blood picture (CBC). 4-Prothrombin time (PT) and Partial thromboplastin (PTT). 5-C reactive protein (CRP). 6-Liver and kidney functions tests fasting and two hours postprandial serum glucose.7-Lipid profile (total cholesterol, triglycerides, HDLcholesterol). 8Specific laboratory investigations: Glycosylated hemoglobin (HbA1c). Assay of fibrinogen. Assay of tissue plasminogen activator (t-PA). The results revealed the following: There was no significant difference between all studied groups as regard age of subjects and duration of clinical diabetes. There was a significant increase in BMI in group III compared to groups I and II but no significant difference was found between group II and group I. t-PA was significantly increased in group II compared to group I but significantly decreased in group III compared to groups I and II. There was a significant increase in HbA1c in group II and group III compared to group I with no significant difference was found between group II and group III. There was a significant increase in fibrinogen in groups II and III compared to group I with no significant difference was found between group II and group III. There was a significant increase in CRP in in groups II and III compared to group I. CRP was also significantly increased in group III compared to group II. There was a significant decrease in the levels of cholesterol In groups II and III compared to group I and significantly lower in group II compared to group III. The level of triglyceride was significantly higher In groups II and III compared to group I, also triglyceride in group III was significantly higher compared to group II. The level of HDL-cholesterol was significantly higher in group II compared to group I and significantly lower in group III compared to groups I and II. There was no significant difference between NON LEAD and LEAD in group II as regards t-PA but in the group III, t-PA was significantly higher in LEAD compared to NON LEAD. There was statistically positive correlation between t-PA and age and diabetic duration in total, NON LEAD and LEAD group II. There were statistically positive correlations between t-PA and age in total, NON LEAD and LEAD group III. There was a statistically positive correlation between t-PA and HbA1c in total group III. There were statistically positive correlation between t-PA and diabetic duration in total, NON LEAD and LEAD group III. [Mahmoud A. Ashour; Hisham Mohamed Omar; Ola Aly Hussein and Nanis A. Salah. Evaluation of Some Fibrinolytic Factors for Assessment of Lower Extremity Arterial Disease (LEAD) in Diabetic Patients. Life Sci J 2012;9(4):5376-5387] (ISSN:1097-8135). http://www.lifesciencesite. com. 798