Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-range Reasoning for Machine Comprehension

We propose MRU (Multi-Range Reasoning Units), a new fast compositional encoder for machine comprehension (MC). Our proposed MRU encoders are characterized by multi-ranged gating, executing a series of parameterized contract-and-expand layers for learning gating vectors that benefit from long and short-term dependencies. The aims of our approach are as follows: (1) learning representations that are concurrently aware of long and short-term context, (2) modeling relationships between intra-document blocks and (3) fast and efficient sequence encoding. We show that our proposed encoder demonstrates promising results both as a standalone encoder and as well as a complementary building block. We conduct extensive experiments on three challenging MC datasets, namely RACE, SearchQA and NarrativeQA, achieving highly competitive performance on all. On the RACE benchmark, our model outperforms DFN (Dynamic Fusion Networks) by 1.5%-6% without using any recurrent or convolution layers. Similarly, we achieve competitive performance relative to AMANDA on the SearchQA benchmark and BiDAF on the NarrativeQA benchmark without using any LSTM/GRU layers. Finally, incorporating MRU encoders with standard BiLSTM architectures further improves performance, achieving state-of-the-art results.
Predictive value from pediatrician plusoptix screening: impact of refraction and binocular alignment.

BACKGROUND The positive predictive value (PPV) of conventional preschool acuity screening is about 50% whereas previous Polaroid photoscreening with experienced interpretation can achieve PPV greater than 85%. The Plusoptix photoscreener has immediate computer interpretation and a CPT code available to pediatricians. METHODS Two Plusoptix SO9 were used in two pediatric group practices with previously validated refractive criteria and new manufacturer's binocular alignment criteria. CPT billing was monitored. Referred patients had prior gold-standard AAPOS examinations. RESULTS 12% of 675 photoscreened preschoolers were referred. Of the 39 with AAPOS gold-standard exams, the PPV from strabismus referrals was 17%, while 26 of 27 refractive referrals had true amblyopia risk factors (PPV 96%). Screening CPT code 99174 reimbursement rose from zero to half of insurers in 15 months. CONCLUSION Plusoptix photoscreening is valid after adjusting the binocular alignment criteria. Such photoscreening should be employed by pediatric practices to detect and ultimately to reduce amblyopia vision impairment in children.
SRTM DEM Correction in Vegetated Mountain Areas through the Integration of Spaceborne LiDAR, Airborne LiDAR, and Optical Imagery

The Shuttle Radar Topography Mission (SRTM) digital elevation model (DEM) is one of the most complete and frequently used global-scale DEM products in various applications. However, previous studies have shown that the SRTM DEM is systematically higher than the actual land surface in vegetated mountain areas. The objective of this study is to propose a procedure to calibrate the SRTM DEM over large vegetated mountain areas. Firstly, we developed methods to estimate canopy cover from aerial imagery and tree height from multi-source datasets (i.e., field observations, airborne light detection and ranging (LiDAR) data, Geoscience Laser Altimeter System (GLAS) data, Landsat TM imagery, climate surfaces, and topographic data). Then, the airborne LiDAR derived DEM, covering ~5% of the study area, was used to evaluate the accuracy of the SRTM DEM. Finally, a regression model of the SRTM DEM error depending on tree height, canopy cover, and terrain slope was developed to calibrate the SRTM DEM. Our results show that the proposed procedure can significantly improve the accuracy of the SRTM DEM over vegetated mountain areas. The mean difference between the SRTM DEM and the LiDAR DEM decreased from 12.15 m to −0.82 m, and the standard deviation dropped by 2 m.
Large-vessel involvement in granulomatosis with polyangiitis successfully treated with rituximab: A case report and literature review

Granulomatosis with polyangiitis (GPA) is primary necrotizing vasculitis, which predominantly affects small to medium vessels. Herein, we describe a case of a 60-year-old female with GPA who developed inflammatory wall thickening localized in the aortic arch, upper abdominal aorta, and pulmonary artery. The wall thickening in the large vessels and other GPA lesions such as lung nodules and orbital mass had failed to respond to high-dose glucocorticoids combined with cyclophosphamide; however, all were successfully treated with rituximab. Our literature review identified 24 cases of large-vessel involvement associated with GPA. Luminal stenosis, occlusion, or wall thickening were observed in 8, periaortitis in 11, and aneurysms in 5 cases. The most commonly affected vessel was the abdominal aorta (12 cases), followed by the thoracic aorta (6 cases), subclavian artery (4 cases), and internal carotid artery (4 cases). Glucocorticoids were used in 23 cases, 20 of which received combination therapy with cyclophosphamide. Surgical or endovascular therapies were performed in 10 cases with aneurysmal dilatation. This is the first case showing the potential efficacy of rituximab for refractory large-vessel involvement associated with GPA.
The Palatal Interpterygoid Vacuities of Temnospondyls and the Implications for the Associated Eye‐ and Jaw Musculature

A diagnostic feature of temnospondyls is the presence of an open palate with large interpterygoid vacuities, unlike the closed palate of most other early tetrapods, in which the vacuities are either slit‐like or completely absent. Attachment sites on neurocranium and palatal bones in temnospondyls allow the reconstruction of a powerful m. retractor bulbi and a large, sheet‐like m. levator bulbi that formed the elastic floor of the orbit. This muscle arrangement indicates that temnospondyls were able to retract the eyeballs through the interpterygoid vacuities into the buccal cavity, like extant frogs and salamanders. In contrast, attachment sites on palate and neurocranium suggest a rather sauropsid‐like arrangement of these muscles in stem‐tetrapods and stem‐amniotes. However, the anteriorly enlarged, huge interpterygoid vacuities of long‐snouted stereospondyls suggest that eye retraction was not the only function of the vacuities here, since the eye‐muscles filled only the posterior part of the vacuities. We propose an association of the vacuities in temnospondyls with a long, preorbital part of the m. adductor mandibulae internus (AMIa). The trochlea‐like, anterior edge of the adductor chamber suggests that a tendon of the AMIa was redirected in an anteromedial direction in the preorbital skull and dorsal to the pterygoids. This tendon then unfolded into a wide aponeurosis bearing the flattened AMIa that filled almost the complete interpterygoid vacuities anterior to the orbits. Our muscle reconstructions permit comprehensive insights to the comparative soft tissue anatomy of early tetrapods and provide the basis for a biomechanic analysis of biting performances in the future. Anat Rec, 300:1240–1269, 2017. © 2017 Wiley Periodicals, Inc.
A Real-Time Facial Expression Recognition System for Online Games

Multiplayer online games (MOGs) have become increasingly popular because of the opportunity they provide for collaboration, communication, and interaction. However, compared with ordinary human communication, MOG still has several limitations, especially in communication using facial expressions. Although detailed facial animation has already been achieved in a number of MOGs, players have to use text commands to control the expressions of avatars. In this paper, we propose an automatic expression recognition system that can be integrated into an MOG to control the facial expressions of avatars. To meet the specific requirements of such a system, a number of algorithms are studied, improved, and extended. In particular, Viola and Jones face-detection method is extended to detect small-scale key facial components; and fixed facial landmarks are used to reduce the computational load with little performance degradation in the recognition accuracy.
Image formation in confocal scanning microscopes

Abstract A scanning microscope may be used in a confocal mode of operation, which results in image formation characteristics very different from those in conventional microscopy. The resolution is improved and the depth of field decreased, both of which properties are particularly useful for applications in microbiology. Image formation in conventional and scanning microscopy is compared and contrasted, with emphasis on the Fourier imaging approach. The effects of aberrations on the transfer function are discussed. Inhalt BUdentstehung in konfokaIen Rastermikroskopen. Ein Rastermikroskop kann in konfokalem Betrieb benutzt werden, die Bildentstehung dabei unterscheidet sich sehr von der Bildentstehung bei der konventionellen Mikroskopie. Die Auflosung wird verbessert und die Feldtiefe vergroBert, beide Eigenschaften sind fiir die Mikrobiologie besonders niitzlich. Die Fourier Formalismen der Bildentstehung fUr das konventionelle und das Rastermikroskop werden einander gegeniibergestellt. Diskutiert wird der EinHuB von Aberrationen auf die tJbertragungsfunktion.
Alterations of lymph nodes evaluation after colon cancer resection: patient and tumor heterogeneity should be taken into consideration

Despite the adequacy of nodal evaluation was gradually improved for colon cancer (CC), rare attention has been paid for the effect of patient and tumor heterogeneity on nodal evaluation. We identified 109902 CC patients in stage I-III from Surveillance, Epidemiology, and End-Results (SEER) database during 2004-2013. The lymph nodes evaluations were separately assessed in different patient- and tumor-related features, including gender, age, T stage, histology, tumor differentiation, tumor size and tumor location. The 5-year cancer specific survival (CSS) was calculated with Kaplan-Meier method, log-rank tests were used to compare the differences of CSS in patients with ≥12 and <12 lymph nodes examined. Here, we identified features including gender, age, T stage, tumor differentiation, tumor size and location were independently associated with the median number of lymph node, the rate of ≥12 lymph nodes and the rate of node positivity of CC patients. We then divided CC patients into 29 subgroups according to different patient- and tumor-related features. The median number of lymph node presented a large variance from 12 to 24, the rate of ≥12 lymph nodes increased from 53.2% to 91.2% under the combined effect of patient and tumor heterogeneity. Furthermore, the positive association between increased lymph nodes count and improved survival couldn't be observed in 8261 CC patients with the effect of this heterogeneity. In conclusion, the tumor and patient heterogeneity lead to large alterations of nodal evaluation; we should pay more attention to this effect in clinical practice.
A Randomized, Multicenter, Double-Blind, Study to Evaluate the Safety and Efficacy of Estradiol Vaginal Cream 0.003% in Postmenopausal Women with Vaginal Dryness as the Most Bothersome Symptom

Abstract Background: Vulvovaginal atrophy (VVA) is characterized by vaginal/vulvar dryness, irritation, dyspareunia, or dysuria. The objective of this study was to examine the efficacy and safety of a very low-dose estradiol vaginal cream (0.003%) applied twice per week in postmenopausal women with VVA-related vaginal dryness. Materials and Methods: In this phase 3, randomized, double-blind, placebo-controlled, multicenter study, postmenopausal women with moderate–severe vaginal dryness as the most bothersome VVA symptom were randomized (1:1) to estradiol cream 0.003% (15 μg estradiol; 0.5 g cream) or placebo (0.5 g cream). Treatments were applied vaginally once daily for 2 weeks followed by two applications/week for 10 weeks. Coprimary outcomes were changes in severity of vaginal dryness, percentage of vaginal superficial and parabasal cells, and vaginal pH at final assessment. Additional outcomes comprised changes in severity of other VVA signs and symptoms. Adverse events (AEs) were assessed. Results: Of the 576 randomized participants, most were white and had an average age of 59 years. At final assessment, estradiol reduced vaginal dryness severity, decreased vaginal pH, increased superficial cell percentage, and decreased parabasal cell percentage versus placebo (p ≤ 0.05, all). Estradiol also reduced vaginal dryness severity at Weeks 4–12 and dyspareunia at Week 8 versus placebo (p ≤ 0.05, all). Improvements in vaginal/vulvar irritation/itching severity and dysuria were similar between estradiol and placebo. Estradiol had comparable rates of treatment-emergent AEs to placebo. No deaths occurred. Conclusions: Very low-dose estradiol vaginal cream (0.003%) dosed twice weekly is an effective and well-tolerated treatment for VVA symptoms and dryness associated with menopause.
Immigration and the Maintenance of Local Species Diversity

Explaining the maintenance of high local species diversity in communities governed by competition for space has been a long‐standing problem in ecology. We present a simple theoretical model to explore the influence of immigration from an external source on local coexistence, species abundance patterns, and ecosystem processes in plant communities. The model is built after classical metapopulation models but is applied to competition for space between individuals and includes immigration by a propagule rain and an extinction threshold for rare species. Our model shows that immigration can have a huge effect on local species diversity in competitive communities where competition for space would lead to the exclusion of all but one species if the community were closed. Local species richness is expected to increase strongly when immigration intensity increases beyond the threshold required for the successful establishment of one or a few individuals. Community structure and species relative abundances are also expected to change markedly with immigration intensity. Increasing immigration causes total space occupation by the community to increase but primary productivity on average to either decrease or stay constant with increasing diversity, depending on the relation between immigration and local reproduction rates. These results stress the need for a regional perspective to understand the processes that determine species diversity, species abundance patterns, and ecosystem functioning in local communities.
Effects of telmisartan on fat distribution: a meta-analysis of randomized controlled trials

Abstract Objectives: Several meta-analyses have confirmed the positive metabolic effects of telmisartan, an angiotensin II receptor blocker that can also act as a partial peroxisome proliferator-activated receptor-γ agonist, compared to those of other angiotensin II receptor blockers. These effects include decreased fasting glucose, glycosylated hemoglobin, interleukin-6, and tumor necrosis factor-α levels. However, no systemic analysis of telmisartan’s effects on body fat distribution has been performed. We performed a meta-analysis of randomized controlled telmisartan trials to investigate its effects on body weight, fat distribution, and visceral adipose reduction. Research design and methods: A literature search was performed using Embase, MEDLINE, and the Cochrane Library between January 1966 and November 2013. Randomized controlled trials in English and meeting the following criterion were included: random assignment of hypertensive participants with overweight/obesity, metabolic syndrome, or glucose intolerance to telmisartan or control therapy group. Results: Of 651 potentially relevant reports, 15 satisfied the inclusion criterion. While visceral fat area was significantly lower in the telmisartan group than in the control group (weighted mean difference = −18.13 cm2, 95% C.I. = −27.16 to −9.11, Pχ2 = 0.19, I2 = 41%), subcutaneous fat area was similar (weighted mean difference =2.94 cm2, 95% C.I. = −13.01 to 18.89, Pχ2 = 0.30, I2 = 17%). Total cholesterol levels were significantly different between the groups (standardized mean difference = −0.24, 95% C.I. = −0.45 to −0.03, Pχ2 = 0.0002, I2 = 67%). Limitations: Limitations include: (1) limited number of studies, especially those evaluating fat distribution; (2) different imaging modalities to assess visceral fat area (V.F.A.) and subcutaneous fat area (S.F.A.); (3) observed heterogeneity. Conclusion: The findings suggest that telmisartan affected fat distribution, inducing visceral fat reduction, and thus could be useful in hypertensive patients with obesity/overweight, metabolic syndrome, or glucose intolerance.
Towards a Query Translation Disambiguation Approach using Possibility Theory

We propose in this paper a combined method for Cross-Language Information Retrieval (CLIR) using statistical and lexical resources. On the one hand, we extracted a bilingual French to English dictionary from aligned texts of the Europarl collection. On the other hand, we built a co-occurrence graph structure and used the BabelNet lexical network to process the disambiguation of translation candidates for ambiguous words. We compared our new possibilistic approach with circuit-based one and studied the impact of query expansion by adopting the pseudo-relevance feedback (PRF) technique. Our experiments are performed using the standard CLEF-2003 collection. The results show the positive impact of PRF on the query translation process. Besides, the possibilistic approach using the co-occurrence graph outperforms the overall circuit-based runs.
Whole-Body Vibrations Associated With Alpine Skiing: A Risk Factor for Low Back Pain?

Alpine skiing, both recreational and competitive, is associated with high rates of injury. Numerous studies have shown that occupational exposure to whole-body vibrations is strongly related to lower back pain and some suggest that, in particular, vibrations of lower frequencies could lead to overuse injuries of the back in connection with alpine ski racing. However, it is not yet known which forms of skiing involve stronger vibrations and whether these exceed safety thresholds set by existing standards and directives. Therefore, this study was designed to examine whole-body vibrations connected with different types of skiing and the associated potential risk of developing low back pain. Eight highly skilled ski instructors, all former competitive ski racers and equipped with five accelerometers and a Global Satellite Navigation System to measure vibrations and speed, respectively, performed six different forms of skiing: straight running, plowing, snow-plow swinging, basic swinging, short swinging, and carved turns. To estimate exposure to periodic, random and transient vibrations the power spectrum density (PSD) and standard ISO 2631-1:1997 parameters [i.e., the weighted root-mean-square acceleration (RMS), crest factor, maximum transient vibration value and the fourth-power vibration dose value (VDV)] were calculated. Ground reaction forces were estimated from data provided by accelerometers attached to the pelvis. The major novel findings were that all of the forms of skiing tested produced whole-body vibrations, with highest PSD values of 1.5–8 Hz. Intensified PSD between 8.5 and 35 Hz was observed only when skidding was involved. The RMS values for 10 min of short swinging or carved turns, as well as all 10-min equivalent VDV values exceeded the limits set by European Directive 2002/44/EC for health and safety. Thus, whole-body vibrations, particularly in connection with high ground reaction forces, contribute to a high risk for low back pain among active alpine skiers.
Mechanism Investigation of Rifampicin-Induced Liver Injury Using Comparative Toxicoproteomics in Mice

Tuberculosis is one of the top causes of death among curable infectious diseases; it is an airborne infectious disease that killed 1.1 million people worldwide in 2010. Anti-tuberculosis drug-induced liver injury is the primary cause of drug-induced liver injury (DILI). Rifampicin is one of the most common anti-tuberculosis therapies and has well-known hepatotoxicity. To understand the mechanism of rifampicin-induced liver injury, we performed a global proteomic analysis of liver proteins by LC-MS/MS in a mouse model after the oral administration of 177 and 442.5 mg/kg rifampicin (LD10 and LD25) for 14 days. Based on the biochemical parameters in the plasma after rifampicin treatment, the hepatotoxic effect of rifampicin in the mouse liver was defined as a mixed liver injury. In the present study, we identified 1101 proteins and quantified 1038 proteins. A total of 29 and 40 proteins were up-regulated and 27 and 118 proteins were down-regulated in response to 177 and 442.5 mg/kg rifampicin, respectively. Furthermore, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses to characterize the mechanism of rifampicin-induced hepatotoxicity. In the molecular function category, glutathione transferase activity was up-regulated and proteins related to arachidonic acid metabolism were down-regulated. In the KEGG pathway enrichment-based clustering analysis, the peroxisome proliferator-activated receptor-γ (PPARγ) signaling pathway, cytochrome P450, glutathione metabolism, chemical carcinogenesis, and related proteins increased dose-dependently in rifampicin-treated livers. Taken together, this study showed in-depth molecular mechanism of rifampicin-induced liver injury by comparative toxicoproteomics approach.
The social image of drinking – mass media campaigns may inadvertently increase binge drinking

Abstract Mass media campaigns that promote responsible drinking are rarely tested for their usefulness in reducing heavy alcohol consumption. Existing campaigns that appeal to responsible drinking while simultaneously displaying young people in social drinking situations may even have paradoxical effects. To examine such possible effects, we drew on a real-world media campaign, which we systematically modified on the basis of recent prototype research. We pilot tested questionnaires (using n = 41 participants), developed two different sets of posters in the style of an existing campaign (n = 39) and investigated their effectiveness (n = 102). In the main study, young men were randomly assigned to one of three conditions: sociable or unsociable binge drinker prototype condition or a control group. Outcome variables were intention, behavioural willingness, attitude, subjective norm, self-efficacy, prototype evaluation and prototype similarity with respect to binge drinking. Binge drinking as a habit was included to control for the fact that habitual drinking in social situations is hard to overcome and poses a particular challenge to interventions. The manipulation check showed that the experimental variation (sociable vs. unsociable drinker prototype condition) was successful. Results of the main study showed that the sociable drinker prototype condition resulted in a higher willingness and – for those with less of a habit – a higher intention to binge drink the next weekend. The unsociable drinker prototype condition had no effects. The results imply that the social components of mass media campaigns might inadvertently exacerbate binge drinking in young men. We therefore advocate against campaigns including aspects of alcohol consumption that might be positively associated with drinker prototype perception. Finally, we provide suggestions for future research.