Miracle-dz/UniFAR-FTUs huggingface dataset:
Revisiting hand-crafted feature for action recognition: a set of improved dense trajectories

We propose a feature for action recognition called Trajectory-Set (TS), on top of the improved Dense Trajectory (iDT). The TS feature encodes only trajectories around densely sampled interest points, without any appearance features. Experimental results on the UCF50, UCF101, and HMDB51 action datasets demonstrate that TS is comparable to state-of-the-arts, and outperforms many other methods; for HMDB the accuracy of 85.4%, compared to the best accuracy of 80.2% obtained by a deep method. Our code is available on-line at this https URL .
A new synthetic matrix metalloproteinase inhibitor reduces human mesenchymal stem cell adipogenesis

Development of adipose tissue requires the differentiation of less specialized cells, such as human mesenchymal stem cells (hMSCs), into adipocytes. Since matrix metalloproteinases (MMPs) play critical roles in the cell differentiation process, we conducted investigations to determine if a novel mercaptosulfonamide-based MMP inhibitor (MMPI), YHJ-7-52, could affect hMSC adipogenic differentiation and lipid accumulation. Enzyme inhibition assays, adipogenic differentiation experiments, and quantitative PCR methods were employed to characterize this inhibitor and determine its effect upon adipogenesis. YHJ-7-52 reduced lipid accumulation in differentiated cells by comparable amounts as a potent hydroxamate MMPI, GM6001. However, YHJ-7-82, a non-inhibitory structural analog of YHJ-7-52, in which the zinc-binding thiol group is replaced by a hydroxyl group, had no effect on adipogenesis. The two MMPIs (YHJ-7-52 and GM6001) were also as effective in reducing lipid accumulation in differentiated cells as T0070907, an antagonist of peroxisome-proliferator activated receptor gamma (PPAR-gamma), at a similar concentration. PPAR-gamma is a typical adipogenic marker and a key regulatory protein for the transition of preadiopocyte to adipocyte. Moreover, MMP inhibition was able to suppress lipid accumulation in cells co-treated with Troglitazone, a PPAR-gamma agonist. Our results indicate that MMP inhibitors may be used as molecular tools for adipogenesis and obesity treatment research.
Covariant theory of particle-vibrational coupling and its effect on the single-particle spectrum

The relativistic mean field (RMF) approach describing the motion of independent particles in effective meson fields is extended by a microscopic theory of particle vibrational coupling. It leads to an energy dependence of the relativistic mass operator in the Dyson equation for the single-particle propagator. This equation is solved in the shell-model of Dirac states. As a result of the dynamics of particle-vibrational coupling we observe a noticeable increase of the level density near the Fermi surface. The shifts of the single-particle levels in the odd nuclei surrounding {sup 208}Pb and the corresponding distributions of the single-particle strength are discussed and compared with experimental data.
Analysis of the length of survival and duration of hospital stay of patients with pertrochanteric femoral fracture (AO 31A1-A3).

BACKGROUND Surgery is the method of choice in patients with pertrochanteric femoral fractures. The aim of the study was to analyse the length of survival and duration of hospital stay of patients versus operative technique and selected prognostic factors, i.e.: changes in hemoglobin (Hg) levels, hematocrit (Ht), as well as age and gender. MATERIAL AND METHODS The subjects of this study were 403 patients with pertrochanteric femoral fractures who were operated on in the period 2005-2008. Information on age, gender, the type of fracture and laboratory parameters was acquired from patient case histories. Dates of death were obtained from the Statistical Office. We analysed the survival rate using Kaplan-Meier's method with Cox's F test and performed a multidimensional dependency analysis of survival (Cox regression model) with Spearman's rank correlation coefficient, and we also used the above-mentioned tests to conduct a regression analysis of the duration of hospitalization. RESULTS 255 patients (63%) underwent DHS fixation, while 108 (27%) were treated with Gamma nails, and 40 (10%) with angled condylar plates. The operative technique and gender were not significantly associated with the predicted length of survival. Factors with an inversely proportional effect on the predicted length of survival comprised age, the difference between admission and postoperative haemoglobin (Hg) levels and the number of pRBC units transfused as a consequence of that difference. The duration of postoperative hospital stay was not significantly related to either the type of implant or gender. The duration of hospital stay was determined by the age of the patient and hemoglobin level on admission. CONCLUSIONS 1. Significant prognostic factors predicting the survival time of patients with pertrochanteric femoral fractures comprise: age, a decrease in Hg levels, and the number of pRBC units transfused during the treatment. 2. The duration of hospital stay depends ultimately on patient age and Hg level on admission. 3. The operative technique and gender have no significant prognostic value regarding the length of survival and duration of hospital stay.
Modeling Temporal Progression of Emotional Status in Mental Health Forum: A Recurrent Neural Net Approach

Patients turn to Online Health Communities not only for information on specific conditions but also for emotional support. Previous research has indicated that the progression of emotional status can be studied through the linguistic patterns of an individual’s posts. We analyze a real-world dataset from the Mental Health section of HealthBoards.com. Estimated from the word usages in their posts, we find that the emotional progress across patients vary widely. We study the problem of predicting a patient’s emotional status in the future from her past posts and we propose a Recurrent Neural Network (RNN) based architecture to address it. We find that the future emotional status can be predicted with reasonable accuracy given her historical posts and participation features. Our evaluation results demonstrate the efficacy of our proposed architecture, by outperforming state-of-the-art approaches with over 0.13 reduction in Mean Absolute Error.
Lumbar Spinal Canal Stenosis Classification Criteria: A New Tool

Study Design Case-control study. Purpose To design a new tool for classifying lumbar spinal canal stenosis (CLSCS). Overview of Literature Grading of patients with lumbar spinal canal stenosis (LSCS) is controversial. Methods The Oswestry disability index (ODI) and the neurogenic claudication outcome score (NCOS) were recorded. Four parameters, which indicate the severity of LSCS disease, including Hufschmidt-grade, grading of magnetic resonance imaging, self-paced walking test, and stenosis ratio (SR) were employed. For the SR, quartile analysis was applied for classifying LSCS and the Hufschmidt-grade was modified into a 4-grade score. An initial score was assigned to each metric based on the severity of LSCS. Using the inverse-variance weighting method, the relative weights of these domains and their categories were determined. The score for all of the cases was obtained based on their weight by summing up the points of the four variables. Quartile analysis was used and a CLSCS score was proposed. Finally, intra- and interobserver reliability, and validity were assessed. Results A total of 357 patients were studied. The final CLSCS score for each case ranged from 4 to 16.5. Based on the quartile analysis, using the new criteria set, the CLSCS score was divided into four categories: CLSCS<7 (grade 0); 7≤CLSCS<10 (grade 1); 10≤CLSCS<13 (grade 2); and 13≤CLSCS≤16.5 (grade 3). The kappa values of for the CLSCS score indicated a perfect agreement. The CLSCS was correlated with the ODI and NCOS. All patients with grade 3 CLSCS were observed in the surgical group. Conclusions The CLSCS score can be helpful for classifying LSCS patients and in the decision-making process.
The Role of Opioid Prescription in Incident Opioid Abuse and Dependence Among Individuals With Chronic Noncancer Pain: The Role of Opioid Prescription

Objective:Increasing rates of opioid use disorders (OUDs) (abuse and dependence) among patients prescribed opioids are a significant public health concern. We investigated the association between exposure to prescription opioids and incident OUDs among individuals with a new episode of a chronic noncancer pain (CNCP) condition. Methods:We utilized claims data from the HealthCore Database for 2000 to 2005. The dataset included all individuals aged 18 and over with a new CNCP episode (no diagnosis in the prior 6 mo), and no opioid use or OUD in the prior 6 months (n=568,640). We constructed a single multinomial variable describing prescription on opioid days supply (none, acute, and chronic) and average daily dose (none, low dose, medium dose, and high dose), and examined the association between this variable and an incident OUD diagnosis. Results:Patients with CNCP prescribed opioids had significantly higher rates of OUDs compared with those not prescribed opioids. Effects varied by average daily dose and days supply: low dose, acute (odds ratio [OR]=3.03; 95% confidence interval [CI], 2.32, 3.95); low dose, chronic (OR=14.92; 95% CI, 10.38, 21.46); medium dose, acute (OR=2.80; 95% CI, 2.12, 3.71); medium dose, chronic (OR=28.69; 95% CI, 20.02, 41.13); high dose, acute (OR=3.10; 95% CI, 1.67, 5.77); and high dose, chronic (OR=122.45; 95% CI, 72.79, 205.99). Conclusions:Among individuals with a new CNCP episode, prescription opioid exposure was a strong risk factor for incident OUDs; magnitudes of effects were large. Duration of opioid therapy was more important than daily dose in determining OUD risk.
Bayesian 3D modeling from images using multiple depth maps

This paper addresses the problem of reconstructing the geometry and color of a Lambertian scene, given some fully calibrated images acquired with wide baselines. In order to completely model the input data, we propose to represent the scene as a set of colored depth maps, one per input image. We formulate the problem as a Bayesian MAP problem which leads to an energy minimization method. Hidden visibility variables are used to deal with occlusion, reflections and outliers. The main contributions of this work are: a prior for the visibility variables that treats the geometric occlusions; and a prior for the multiple depth maps model that smoothes and merges the depth maps while enabling discontinuities. Real world examples showing the efficiency and limitations of the approach are presented.
Reliability of a Novel CBCT-Based 3D Classification System for Maxillary Canine Impactions in Orthodontics: The KPG Index

The aim of this study was to evaluate both intra- and interoperator reliability of a radiological three-dimensional classification system (KPG index) for the assessment of degree of difficulty for orthodontic treatment of maxillary canine impactions. Cone beam computed tomography (CBCT) scans of fifty impacted canines, obtained using three different scanners (NewTom, Kodak, and Planmeca), were classified using the KPG index by three independent orthodontists. Measurements were repeated one month later. Based on these two sessions, several recommendations on KPG Index scoring were elaborated. After a joint calibration session, these recommendations were explained to nine orthodontists and the two measurement sessions were repeated. There was a moderate intrarater agreement in the precalibration measurement sessions. After the calibration session, both intra- and interrater agreement were almost perfect. Indexes assessed with Kodak Dental Imaging 3D module software showed a better reliability in z-axis values, whereas indexes assessed with Planmeca Romexis software showed a better reliability in x- and y-axis values. No differences were found between the CBCT scanners used. Taken together, these findings indicate that the application of the instructions elaborated during this study improved KPG index reliability, which was nevertheless variously influenced by the use of different software for images evaluation.
Chinese-Japanese Cross Language Information Retrieval: A Han Character Based Approach

In this paper, we investigate cross language information retrieval (CLIR) for Chinese and Japanese texts utilizing the Han characters -- common ideographs used in writing Chinese, Japanese and Korean (CJK) languages. The Unicode encoding scheme, which encodes the superset of Han characters, is used as a common encoding platform to deal with the multilingual collection in a uniform manner. We discuss the importance of Han character semantics in document indexing and retrieval of the ideographic languages. We also analyse the baseline results of the cross language information retrieval using the common Han characters appeared in both Chinese and Japanese texts.
Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats

Objective. To investigate the effects of static magnetic field (SMF) on cutaneous wound healing of Streptozotocin- (STZ-) induced diabetic rats. Methods. 20 STZ-induced diabetic rats were randomly divided into two groups (10 in each group): diabetic rats with SMF exposure group which were exposed to SMF by gluing one magnetic disk of 230 mT intensity and diabetic rats with sham SMF exposure group (sham group). 10 normal Wistar rats were used as the control group. One open circular wound with 2 cm diameter in the dorsum was generated on both normal and diabetic rats and then covered with sterile gauzes. Wound healing was evaluated by wound area reduction rate, mean time to wound closure, and wound tensile strength. Results. The wound area reduction rate in diabetic rats in comparison with the control group was significantly decreased (P < 0.01). Compared with sham magnet group, diabetic rats under 230 mT SMF exposure demonstrated significantly accelerated wound area reduction rate on postoperative days 7, 14, and 21 and decreased gross time to wound closure (P < 0.05), as well as dramatically higher wound tissue strength (P < 0.05) on 21st day. Conclusion. 230 mT SMF promoted the healing of skin wound in diabetic rats and may provide a non-invasive therapeutic tool for impaired wound healing of diabetic patients.
Interactive Genetic Algorithms for Use as Creativity Enhancement Tools

It is proposed that creativity can be enhanced through the use of interactive genetic algorithms (IGAs). Divergent and convergent thinking are important processes in creativity that we simulate through two separate IGA populations developed by different means. The convergent process hones in on specific designs, while the divergent process explore design possibilities in a fashion beyond pure mutation techniques typically used to introduce population diversity. This study uses Monte Carlo simulation to explore the effect of merging two populations developed by the divergent and convergent methods. The results suggest that population diversity benefits from these population combinations while not adversely affecting the ability of the user to find a goal design. This IGA has also been developed in Adobe Flash so that it can be deployed on the internet to conduct validation and studies of creativity.
1 WHY STUDY PROTEOMICS IN STEM CELLS AND DEVELOPMENT ?

Genomics methodologies have advanced to the extent that it is now possible to interrogate the gene expression in a single cell but proteomics has traditionally lagged behind and required much greater cellular input and was not quantitative. Coupling protein with gene expression data is essential for understanding how cell behavior is regulated. Advances primarily in mass spectrometry have, however, greatly improved the sensitivity of proteomics methods over the last decade and the outcome of proteomic analyses can now also be quantified. Nevertheless, it is still difficult to obtain sufficient tissue from staged mammalian embryos to combine proteomic and genomic analyses. Recent developments in pluripotent stem cell biology have in part addressed this issue by providing surrogate scalable cell systems in which early developmental events can be modeled. Here we present an overview of current proteomics methodologies and the kind of information this can provide on the biology of human and mouse pluripotent stem cells.
Efficacy of Fluon Conditioning for Capturing Cerambycid Beetles in Different Trap Designs and Persistence on Panel Traps Over Time

ABSTRACT Fluon PTFE is a fluoropolymer dispersion applied as a surface conditioner to cross-vane panel traps to enhance trap efficiency for cerambycid beetles. We describe the results of three experiments to further optimize cerambycid traps of different designs and to test the effect of Fluon over time. We tested Fluon with Lindgren funnel and panel traps fitted with either wet or dry collection cups on catches of cerambycid beetles and how the effect of Fluon on panel traps persisted. Fluon-treated funnel traps with wet collection cups captured ≈6× more beetles than the untreated funnel traps with wet collection cups. Untreated funnel traps with dry collection cups did not capture any beetles; however, Fluon-treated funnel traps with dry collection cups captured an average of four beetles per trap. Fluon-treated panel traps with wet collection cups captured ≈9× more beetles than untreated panel traps with wet collection cups. Fluon-treated panel traps with dry collection cups captured ≈11× more beetles than untreated panel traps with dry collection cups. The effect of Fluon on capturing cerambycid beetles did not decline after use in one or two field seasons. There was no significant difference in the number of beetles captured in freshly treated panel traps compared with traps that had been used for 1 or 2 yr. Fluon-treated traps captured nine species that were not captured in untreated traps. Conditioning both Lindgren funnel and panel traps with Fluon enhances the efficacy and sensitivity of traps deployed to detect exotic cerambycid species, or for monitoring threatened species at low population densities.
Feasibility of reconstructed ancestral H5N1 influenza viruses for cross-clade protective vaccine development

Since the reemergence of highly pathogenic H5N1 influenza viruses in humans in 2003, these viruses have spread throughout avian species in Asia, Europe, and Africa. Their sustained circulation has resulted in the evolution of phylogenetically diverse lineages. Viruses from these lineages show considerable antigenic variation, which has confounded vaccine planning efforts. We reconstructed ancestral protein sequences at several nodes of the hemagglutinin (HA) and neuraminidase (NA) gene phylogenies that represent ancestors to diverse H5N1 virus clades. By using the same methods that have been used to generate currently licensed inactivated H5N1 vaccines, we were able to produce a panel of replication competent influenza viruses containing synthesized HA and NA genes representing the reconstructed ancestral proteins. We identified two of these viruses that showed promising in vitro cross-reactivity with clade 1, 2.1, 2.2, 2.3. 4, and 4 viruses. To confirm that vaccine antigens derived from these viruses were able to elicit functional antibodies following immunization, we created whole-virus vaccines and compared their protective efficacy versus that of antigens from positive control, naturally occurring, and broadly reactive H5N1 viruses. The ancestral viruses’ vaccines provided robust protection against morbidity and mortality in ferrets challenged with H5N1 strains from clades 1, 2.1, and 2.2 in a manner similar to those based on the control strains. These findings provide proof of principle that viable, computationally derived vaccine seed viruses can be constructed within the context of currently licensed vaccine platforms. Such technologies should be explored to enhance the cross reactivity and availability of H5N1 influenza vaccines.
A Case Report of the Symptom-Relieving Action of an Anterior Flat Plane Bite Plate for Temporomandibular Disorder

Splint therapy is a widely used modality for temporomandibular disorders (TMDs). However, questions remain regarding the mechanism of symptom relief. Recently, a relation between TMD and a discrepancy between the habitual occlusal position (HOP) and the anterior flat plane bite plate-induced occlusal position (BPOP) has been reported. Therefore, to understand the mechanism of the symptom relief associated with the use of a bite plate, the changes in both the HOP and BPOP values were observed during anterior bite plate treatment in a patient with TMD. Case presentation Anterior bite plate treatment was started in a patient complaining of arthralgia. A discrepancy between the HOP and BPOP values was recorded three days after the first visit; this discrepancy disappeared on day 6, and the disappearance was maintained between days 6 and 12. The disappearance was associated with a decrease in the severity of the patient’s symptoms; however, the discrepancy reappeared after 15 days, coinciding with the complete disappearance of the patient’s symptoms. Therefore, the effect of the bite plate on the resolution of the discrepancy between the HOP and BPOP values was interpreted as being unsustainable and occlusal equilibration for the BPOP was performed at 17 days. Thereafter, neither a discrepancy in the HOP and BPOP values nor any symptoms of TMD (right temporomandibular joint pain or limited jaw opening) reoccurred during a two-year follow-up period. Conclusion Within the limitations of the present study, the symptom-relieving action of an anterior flat plane bite plate on the resolution of occlusal discrepancy appeared to be temporary. This outcome supports previously reported conclusions that the effectiveness of stabilization splint therapy for reducing symptoms in patients with pain dysfunction syndrome does not differ significantly from that of other conservative therapies or of no treatment at all.