Miracle-dz/UniFAR-FTUs huggingface dataset:
Some informational aspects of visual perception.

xThe ideas of information theory are at present stimulating many different areas of psychological inquiry. In providing techniques for quantifying situations which have hitherto been difficult or impossible to quantify, they suggest new and more precise ways of conceptualizing these situations (see Miller [12] for a general discussion and bibliography). Events ordered in time are particularly amenable to informational analysis; thus language sequences are being extensively studied, and other sequences, such as those of music, plainly invite research. In this paper I shall indicate some of the ways in which the concepts and techniques of information theory may clarify our understanding of visual perception. When we begin to consider perception as an information-handling process, it quickly becomes clear that much of the information received by any higher organism is redundant. Sensory events are highly interdependent in both space and time: if we know at a given moment the states of a limited number of receptors (i.e., whether they are firing or not firing), we can make better-than-chance inferences with respect to the prior and subsequent states of these receptors, and also with respect to the present, prior, and subsequent states of other receptors. The preceding statement, taken in its broadest im1 The experimental work for this study was performed as part of the United States Air Force Human Resources Research and Development Program. The opinions and conclusions contained in this report are those of the author. They are not to be construed as reflecting the views or indorsement of the Department of the Air Force. plications, is precisely equivalent to an assertion that the world as we know it is lawful. In the present discussion, however, we shall restrict our attention to special types of lawfulness which may exist in space at a fixed time, and which seem particularly relevant to processes of visual perception.
Catecholamine-induced myocardial fibrosis and oxidative stress is attenuated by Terminalia arjuna (Roxb.).

OBJECTIVES Myocardial fibrosis and oxidative stress accompany a number of cardiac disorders such as hypertrophic cardiomyopathy, hypertensive heart disease and cardiac failure. Stem bark of Terminalia arjuna has been advocated for cardiac ailments. The present study evaluated the effects of T. arjuna bark extract on myocardial fibrosis and oxidative stress induced by chronic beta-adrenoceptor stimulation. METHODS Aqueous extract of T. arjuna bark was evaluated at 63, 125 and 250 mg/kg given orally for antifibrotic and antioxidant effects in rats given the selective beta-adrenoceptor agonist isoprenaline (5 mg/kg s.c.) for 28 days. Captopril (50 mg/kg per day, given orally), an inhibitor of angiotensin-converting enzyme used as a standard cardioprotective drug, was used as a positive control. KEY FINDINGS Isoprenaline caused fibrosis, increased oxidative stress and cardiac hypertrophy (increased heart weight : body weight ratio and cardiomyocyte diameter). The T. arjuna bark extract and captopril significantly prevented the isoprenaline-induced increase in oxidative stress and decline in endogenous antioxidant level. Both also prevented fibrosis but not the increase in heart weight : body weight ratio. CONCLUSIONS T. arjuna protects against myocardial changes induced by chronic beta-adrenoceptor stimulation.
Python PSS/E simulation to test efficacy of proposed PMU based WAMS and potential WAMPAC applications

A PSS/E 32 model of a real section of the Northern Ireland electrical grid was dynamically controlled with Python 2.5. In this manner data from a proposed wide area monitoring system was simulated. The area is of interest as it is a weakly coupled distribution grid with significant distributed generation. The data was used to create an optimization and protection metric that reflected reactive power flow, voltage profile, thermal overload and voltage excursions. Step changes in the metric were introduced upon the operation of special protection systems and voltage excursions. A wide variety of grid conditions were simulated while tap changer positions and switched capacitor banks were iterated through; with the most desirable state returning the lowest optimization and protection metric. The optimized metric was compared against the metric generated from the standard system state returned by PSS/E. Various grid scenarios were explored involving an intact network and compromised networks (line loss) under summer maximum, summer minimum and winter maximum conditions. In each instance the output from the installed distributed generation is varied between 0 MW and 80 MW (120% of installed capacity). It is shown that in grid models the triggering of special protection systems is delayed by between 1 MW and 6 MW (1.5% to 9% of capacity), with 3.5 MW being the average. The optimization and protection metric gives a quantitative value for system health and demonstrates the potential efficacy of wide area monitoring for protection and control.
Why We Hate Politics

* Preface and Acknowledgements * Chapter 1 Political Disenchantment * Chapter 2 Politics, Participation and Politicisation * Chapter 3 The Domestic Sources of Depoliticisation * Chapter 4 The Global Sources of Depoliticisation * Chapter 5 Conclusion: Why Do We Hate Politics? * Bibliography * Index
Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes

During the CD4−CD8− (DN) stage of T-cell development, RAG-dependent DNA breaks and V(D)J recombination occur at three T-cell receptor (TCR) loci: TCRβ, TCRγ and TCRδ. During this stage, abnormal trans-rearrangements also take place between TCR loci, occurring at increased frequency in absence of the DNA damage response mediator ataxia telangiectasia mutated (ATM). Here, we use this model of physiologic trans-rearrangement to study factors that predispose to rearrangement and the role of ATM in preventing chromosomal translocations. The frequency of DN thymocytes with DNA damage foci at multiple TCR loci simultaneously is increased 2- to 3-fold in the absence of ATM. However, trans-rearrangement is increased 10 000- to 100 000-fold, indicating that ATM function extends beyond timely resolution of DNA breaks. RAG-mediated synaptic complex formation occurs between recombination signal sequences with unequal 12 and 23 base spacer sequences (12/23 rule). TCR trans-rearrangements violate this rule, as we observed similar frequencies of 12/23 and aberrant 12/12 or 23/23 recombination products. This suggests that trans-rearrangements are not the result of trans-synaptic complex formation, but they are instead because of unstable cis synaptic complexes that form simultaneously at distinct TCR loci. Thus, ATM suppresses trans-rearrangement primarily through stabilization of DNA breaks at TCR loci.
Novel and conventional biomarkers for prediction of incident cardiovascular events in the community.

CONTEXT Prior studies have demonstrated conflicting results regarding how much information novel biomarkers add to cardiovascular risk assessment. OBJECTIVE To evaluate the utility of contemporary biomarkers for predicting cardiovascular risk when added to conventional risk factors. DESIGN, SETTING, AND PARTICIPANTS Cohort study of 5067 participants (mean age, 58 years; 60% women) without cardiovascular disease from Malmö, Sweden, who attended a baseline examination between 1991 and 1994. Participants underwent measurement of C-reactive protein (CRP), cystatin C, lipoprotein-associated phospholipase 2, midregional proadrenomedullin (MR-proADM), midregional proatrial natriuretic peptide, and N-terminal pro-B-type natriuretic peptide (N-BNP) and underwent follow-up until 2006 using the Swedish national hospital discharge and cause-of-death registers and the Stroke in Malmö register for first cardiovascular events (myocardial infarction, stroke, coronary death). MAIN OUTCOME MEASURES Incident cardiovascular and coronary events. RESULTS During median follow-up of 12.8 years, there were 418 cardiovascular and 230 coronary events. Models with conventional risk factors had C statistics of 0.758 (95% confidence interval [CI], 0.734 to 0.781) and 0.760 (0.730 to 0.789) for cardiovascular and coronary events, respectively. Biomarkers retained in backward-elimination models were CRP and N-BNP for cardiovascular events and MR-proADM and N-BNP for coronary events, which increased the C statistic by 0.007 (P = .04) and 0.009 (P = .08), respectively. The proportion of participants reclassified was modest (8% for cardiovascular risk, 5% for coronary risk). Net reclassification improvement was nonsignificant for cardiovascular events (0.0%; 95% CI, -4.3% to 4.3%) and coronary events (4.7%; 95% CI, -0.76% to 10.1%). Greater improvements were observed in analyses restricted to intermediate-risk individuals (cardiovascular events: 7.4%; 95% CI, 0.7% to 14.1%; P = .03; coronary events: 14.6%; 95% CI, 5.0% to 24.2%; P = .003). However, correct reclassification was almost entirely confined to down-classification of individuals without events rather than up-classification of those with events. CONCLUSIONS Selected biomarkers may be used to predict future cardiovascular events, but the gains over conventional risk factors are minimal. Risk classification improved in intermediate-risk individuals, mainly through the identification of those unlikely to develop events.
Job satisfaction and retirement age intentions in Finland: Self-employed versus salary earners

Purpose - The purpose of this paper is to analyse the effect of job satisfaction on the intended retirement age of self-employed and organisationally-employed white-collar professionals. The analysis also examines potential boundary conditions imposed by other domains of life for the applicability of this relationship. Design/methodology/approach - The study employs ordered probit regressions to analyse primary survey data comprising 1,262 Finnish white-collar professionals. Findings - The econometric results suggest that job satisfaction is a significant determinant of the intention to retire later and thus prolong a career. The analysis does not find a difference in the effect of job satisfaction between salary earners and self-employed individuals. However, the analysis finds that other domains of life influence how job satisfaction affects retirement-age intentions, and that these influences differ between self-employed and salaried respondents. Practical implications - The findings imply that developing measures to improve the job satisfaction of (highly educated) older workers is an alternative to the widely debated regulatory approach of prolonging working careers by increasing the statutory retirement age. The principal limitation is the focus on white-collar professionals in a single country. Originality/value - This is the first empirical comparison of the effect of job satisfaction on the intended retirement age between salary earners and self-employed individuals. It is also the first examination of the effect of job satisfaction on retirement intentions or behaviour that accounts for the effects of other domains of life satisfaction.
A decentralized control strategy for multiple distributed generation in islanded mode

A technical challenge is designing a controller to control multiple distributed generation (DG) and its local loads by voltage-sourced converter (VSC) to operate in an islanded mode under the load parameters uncertainty, and unbalanced and transient conditions. Model predictive control (MPC) for the autonomous operation of multiple DG is proposed. The MPC is designed for multiple inputs and multiple outputs (MIMO) systems, and takes into consideration constraints, and nonlinearities. In this paper, the MPC-based voltage controller is combined with a fast current controller using a discrete time sliding mode controller (DSMC) for limiting the inverter currents under overload condition. The proposed control strategy provides fast tracking, robustness, fast transient recovery, less distortion, and minimal overshoots in voltage and current under 1) the short circuit conditions, 2) load transients and 3) unbalanced loads. Various scenarios including the reference signal tracking and robustness against the load perturbations are considered.
Social comparison orientation: a new perspective on those who do and those who don’t compare with others.

Social comparison as an individual difference characteristic Social comparison – how we use others to make sense of ourselves and our social world – is a focal human concern. Indeed, scholars have long recognized the importance of social comparison for human adaptation and survival. As Suls and Wheeler (2000) have noted, theorizing and research on social comparison can be traced to some of the classic contributions to western philosophy and to pivotal work in social psychology and sociology, including work on the self, adaptation level, reference groups, and social influence. In many respects, it is a fundamental human social interaction process. Nevertheless, it was not until Festinger's (1954) classic paper that the term social comparison was proposed. According to Festinger, “There exists, in the human organism, a drive to evaluate his opinions and abilities. ” (p. 117) Although they generally do not like the term “drive,” most social psychologists would probably agree that the desire to learn about the self through comparison with others is a universal characteristic of humans. As P. Gilbert, Price, and Allan (1995) noted, social comparison is phylogenetically very old, biologically very powerful, and is recognizable in many species. Indeed, it has been suggested that the process of social comparison has an evolutionary basis, and stems from the need to assess one's power and strength compared to that of one's competitors. In the course of evolution, this tendency to compare oneself with others has undoubtedly increased as humans came to live in larger groups.
Soluble P-Selectin in Human Plasma: Effect of Anticoagulant Matrix and its Levels in Patients With Cardiovascular Disorders

P-Selectin represents a cell surface glycoprotein that is constitutively present in the Weibel-Palade bodies of endothelial cells and in the α-granules of platelets. In inflam mation and thrombogenic conditions, plasmatic P-selectin lev els are markedly elevated, indicating the leakage of this marker from these sites. In this study, a quantitative sandwich enzyme- linked immunosorbent assay (ELISA) utilizing a monoclonal soluble P-selectin (sP-selectin) antibody was employed to as sess this marker in blood samples collected in various antico agulants such as heparin, hirudin, sodium citrate (3.2% and 3.8%), and ethylenediaminetetraacetic acid (EDTA). The soluble P-selectin levels ranged from 26 ng/mL to 44 ng/mL. Sodium citrate (3.8%) was used to collect platelet-poor plasma (PPP) from patients with heparin-induced thrombocytopenia (HIT), coronary angioplasty (CA), or coronary atherectomy (CAT). In comparison with the control group (∼ 30 ng/mL), all of these patient groups showed a marked elevation of sP- selectin levels (HIT = 96 ng/mL [n = 18], CA = 46 ng/mL [n = 6] and CAT = 60 ng/mL [n = 10]). In platelet-rich plasma (PRP) preparations using various anticoagulants, the sP-selectin levels were markedly higher, ranging from 87 ng/ mL to 117 ng/mL (n = 10). In patients recruited into a clinical trial (the argatroban [ARG] 911 Study), in which argatroban was used as an alternate anticoagulant in patients with HIT, a 25% to 35% decrease in sP-selectin levels was observed after 72 hours of argatroban treatment. In addition, the relative ratio between levels in PRP and PPP in these patients differed, sug gesting that the anticoagulant matrix influences the sP-selectin levels. These data clearly suggest that the anticoagulant matrix and blood collection procedures may significantly influence the plasmatic P-selectin levels. Furthermore, in different clinical conditions, elevation of this marker may reflect endogenous platelet activation; however, optimal anticoagulant for blood collection is important for proper diagnostic valida tion.
Predicting physical activity energy expenditure in manual wheelchair users.

PURPOSE This study aimed to assess the influence of anatomical placement of an accelerometer on physical activity energy expenditure prediction in manual wheelchair users. METHODS Ten accelerometer units (ActiGraph GT3X+) were attached to a multiaxis shaker table and subjected to a sinusoidal oscillation procedure to assess mechanical validity and reliability. Fifteen manual wheelchair users (mean ± SD: age, 36 ± 11 yr; body mass, 70 ± 12 kg) then completed five activities, including desk work and wheelchair propulsion (2, 4, 6, and 8 km·h). Expired gases were collected throughout. GT3X+ accelerometers were worn on the right wrist, upper arm, and waist. The relations between physical activity counts and metabolic rate were subsequently assessed, and bias ± 95% limits of agreement was calculated. RESULTS During mechanical testing, coefficients of variation ranged from 0.2% to 4.7% (intraunit) and 0.9% to 5.2% (interunit) in all axes. During human exercise testing, physical activity counts at each anatomical location was significantly (P < 0.01) correlated with metabolic rate (wrist, r = 0.93; upper arm, r = 0.87; waist, r = 0.73). The SEE for each correlation were 3.34, 4.38, and 6.07 kJ·min for the wrist, upper arm, and waist, respectively. The absolute bias ± 95% limits of agreement values were 0.0 ± 6.5 kJ·min, 0.0 ± 8.5 kJ·min, and 0.0 ± 11.8 kJ·min for the wrist, upper arm, and waist, respectively. CONCLUSIONS The ActiGraph GT3X+ is a reliable tool for determining mechanical movements within the physiological range of human movement. Of the three anatomical locations considered, a wrist-mounted accelerometer explains more of the variance and results in the lowest random error when predicting physical activity energy expenditure in manual wheelchair users.
Increased Escherichia coli Phagocytosis in Neutrophils That Have Transmigrated across a Cultured Intestinal Epithelium

ABSTRACT The functionality of polymorphonuclear leukocytes (PMNs) once they migrate into the digestive lumen is still ill defined. More specifically, phagocytic function and bactericidal action of PMNs after transepithelial migration have not received much attention. The aim of the present study is to compare PMN behavior before and after transepithelial migration, in particular (i) phagocytosis and bactericidal activity; (ii) expression of surface molecules, particularly those involved in phagocytosis; and (iii) apoptosis. Cultured human intestinal epithelial T84 cell monolayers were used. The effect of transepithelial migration on phagocytosis was evaluated by immunofluorescence and electron microscopy and by flow cytometric assessment of the engulfment of a strain of Escherichia coli transfected with the green fluorescent protein. Superoxide production by PMNs was investigated by luminol-mediated chemiluminescence. Expression of various surface molecules on PMNs was evaluated by flow cytometry, while PMN apoptosis was assayed by morphologic changes and DNA fragmentation. E. coliphagocytosis by the PMNs was markedly increased after transepithelial migration without modification of superoxide production. CD11b/CD18 and CD47 expression was increased upon PMN transmigration, whereas CD16 expression was decreased and CD29, CD46, CD49e, CD49f, CD55, CD59, CD61, CD95 levels remained unchanged. Apoptosis in transmigrated PMNs was slightly advanced and was observed after 12 h compared to 16 h for nontransmigrated PMNs. In conclusion, the phagocytic capacity of the PMNs is augmented after transepithelial migration, with a dramatic increase in the level of CD11b/CD18 and preservation of the superoxide production. These results suggest a higher bactericidal activity of the PMNs once they have translocated into the digestive lumen.
The Nationalization of Special Elections for the U.S. House of Representatives

AbstractScholars and political commentators have argued that special elections to the U.S. House of Representatives are national contests, serving as a referendum on the president's party and a predictor of future election outcomes (Sigelman 1981; Smith and Burnnell 2010). But the empirical record is mixed, with one leading study demonstrating that candidate and district characteristics alone explain special election outcomes (Gaddie, Bullock, and Buchanan 1999). We investigate this disagreement by comparing special election and open-seat results using new data for the period 1995–2014. We find that while candidate characteristics affect special election outcomes, presidential approval is predictive of special election outcomes as well. Furthermore, we find that the effect of presidential approval on special election outcomes has increased in magnitude from 1995 to 2014, with the 2002 midterm representing an important juncture in the nationalization of special elections. We conclude that special elections.
Valuing Credit Derivatives

redit derivatives are potentially one of the most important new types of financial products introduced during the past decade. Many investors C have portfolios with values that are highly sensitive to shifts in the spread between risky and riskless yields, and credit derivatives offer these investors an important new tool for managing and hedging their exposure to this type of risk. In this article, we develop a simple framework for valuing derivatives on credit spreads. It captures the major empirical properties of observed credit spreads in that in allows for spreads to be stationary and meanreverting. We then use this framework to derive simple closed-form solutions for the prices of call and put options on the credit spread. These closed-form solutions have a number of interesting implications for the pricing and hedging properties of credit derivatives. We show that calls and puts on the credit spread can have prices below their intrinsic value. We also show that credit spread calls can have negative convexity, and that the delta of the call can be higher for out-of-the-money and at-the-money calls than for in-the-money calls. In addition, we show that the deltas of both calls and puts converge to zero as the time until expiration increases, which implies that long-term credit derivatives may have little abdity to hedge against current shifts in credit spreads.