Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiple pathways of T-T interaction in the generation of cytotoxic T lymphocytes to alloantigens

The interaction of T helper (Th) cells with syngeneic and allogeneic cytotoxic T lymphocyte precursors (CTL.P) has been investigated. Unprimed and mixed lymphocyte culture-primed peripheral T cells were used as a source of Th. Thymocytes, which depend upon exogenous Th cells for activation, were used as a source of cytotoxic precursors. Data is presented that demonstrates that at least two pathways of T-T interaction can lead to the activation of cytotoxic lymphocytes. The first is an allogeneic effect, in which Th cells recognize and respond to alloantigens expressed on CTL.P. The second is the interaction of Th cells with syngeneic CTL.P, in which both cell types are thought to respond to alloantigens on stimulator cells. The latter interaction can be shown to be restricted by H-2-linked determinants when primed Th cells are used and allogeneic effects against thymocytes are minimized. Restricted interactions between unprimed Th cells and thymocyte CTL.P have never been observed. Mechanisms that may explain the difference between the interaction of unprimed and primed Th cells with CTL.P are discussed.
Beliefs Regarding the Impact of Accent Within Speech-Language Pathology Practice Areas

With the demographic shifts in the United States, it is increasingly the case that speech-language pathologists (SLPs) come from different language backgrounds from those of their clients and have nonnative accents in their languages of service. An anonymous web-based survey was completed by students and clinic directors in SLP training programs in New York State regarding their beliefs about the appropriate scope of practice of SLPs with accents in English and other languages. Responses were received from 28 directors and 530 students. Perceived appropriateness of service by accented clinicians depended on particular disorders serviced and degree of accent, with phonologically based services believed by the greatest number of respondents to require more native-like speech than other areas. Further efforts must be made to research effects of SLPs’ accents on service delivery and plan strategies, if needed, for successful service provision in SLPs’ diverse areas of practice when mismatches in language backgrounds occur.
Accurate Tempo Estimation Based on Recurrent Neural Networks and Resonating Comb Filters

In this paper we present a new tempo estimation algorithm which uses a bank of resonating comb filters to determine the dominant periodicity of a musical excerpt. Unlike existing (comb filter based) approaches, we do not use handcrafted features derived from the audio signal, but rather let a recurrent neural network learn an intermediate beat-level representation of the signal and use this information as input to the comb filter bank. While most approaches apply complex post-processing to the output of the comb filter bank like tracking multiple time scales, processing different accent bands, modelling metrical relations, categorising the excerpts into slow / fast or any other advanced processing, we achieve state-of-the-art performance on nine of ten datasets by simply reporting the highest resonator’s histogram peak.
0 Energy Modelling of Software for a Hardware Multi-threaded Embedded Microprocessor

This paper examines a hardware multi-threaded microprocessor and discusses the impact such an architecture has on existing software energy modelling techniques. A framework is constructed for analysing the energy behaviour of the XMOS XS1-L multi-threaded processor and a variation on existing software energy models is proposed, based on analysis of collected energy data. It is shown that by combining execution statistics with sufficient data on the processor’s thread activity and instruction execution costs, a multi-threaded software energy model used with Instruction Set Simulation can yield an average error margin of less than 7%.
Music Training, Cognition, and Personality

Although most studies that examined associations between music training and cognitive abilities had correlational designs, the prevailing bias is that music training causes improvements in cognition. It is also possible, however, that high-functioning children are more likely than other children to take music lessons, and that they also differ in personality. We asked whether individual differences in cognition and personality predict who takes music lessons and for how long. The participants were 118 adults (Study 1) and 167 10- to 12-year-old children (Study 2). We collected demographic information and measured cognitive ability and the Big Five personality dimensions. As in previous research, cognitive ability was associated with musical involvement even when demographic variables were controlled statistically. Novel findings indicated that personality was associated with musical involvement when demographics and cognitive ability were held constant, and that openness-to-experience was the personality dimension with the best predictive power. These findings reveal that: (1) individual differences influence who takes music lessons and for how long, (2) personality variables are at least as good as cognitive variables at predicting music training, and (3) future correlational studies of links between music training and non-musical ability should account for individual differences in personality.
Understanding Ethics in Practice: An Ethnomethodological Approach to the Study of Business Ethics

Business ethics is an eclectic blend of intellectual traditions that seeks to exam ine the question of “what should I do in my business relationships. ” This paper attempts to widen this discussion by proposing an alternative view of the nature of ethical behaviour: ethical behaviour as a situated social accomplishment. From an ethnomethodological perspective, norms and rules have the status of interpretive aids which are used to negotiate an acceptable meaning for a situation; norms and rules are constituted by, and in part constitute, the situations in which they occur. While most work in business ethics has tended to reify ethical practices, this paper stresses the contingent and situational nature of ethical decision making. In addition to presenting an ethnomethodological perspective, this paper discusses the methodological ramifications of this perspective through an examination of three ethnographic studies of situated rule usage. For any worthwhile study of society must be philosophical in character and any worthwhile philosophy nzust be concerned with the nature of human society. – Peter Wirch (1958: 3)
Sub-state nationalism in Spain: primers and triggers of identity politics in Catalonia and the Basque Country

This article builds on recent attempts to explain divergent uses of sub-state nationalism to push for policies of assimilation or multiculturalism and drive popular support for independence. It analyses the dynamics of discourses and policies in Spain before, during and after peak times of identity politics to provide a more nuanced understanding of the conditions leading to the activation of identity-driven policies. Substantive ethnographic evidence is presented to explain recent alterations to national discourses of identity, surprising reversals of immigration policies, and the modulation of Catalan and Basque independence movements. The main finding is that both identity discourses and resulting policies depend on the affinity for identity politics at the sub-state level, and this affinity is in large part primed by the popular perception of how secure sub-state national identity is against the ‘official’ state narrative.
Myocardial volume and organization are changed by failure of addition of secondary heart field myocardium to the cardiac outflow tract

Cardiac neural crest ablation results in primary myocardial dysfunction and failure of the secondary heart field to add the definitive myocardium to the cardiac outflow tract. The current study was undertaken to understand the changes in myocardial characteristics in the heart tube, including volume, proliferation, and cell size when the myocardium from the secondary heart field fails to be added to the primary heart tube. We used magnetic resonance and confocal microscopy to determine that the volume of myocardium in the looped heart was dramatically reduced and the compact layer of myocardium was thinner after neural crest ablation, especially in the outflow tract and ventricular regions. Proliferation measured by 5‐bromo‐2′‐deoxyuridine incorporation was elevated at only one stage during looping, cell death was normal and myocardial cell size was increased. Taken together, these results indicate that there are fewer myocytes in the heart. By incubation day 8 when the heart would have normally completed septation, the anterior (ventral) wall of the right ventricle and right ventricular outflow tract was significantly thinner in the neural crest‐ablated embryos than normal, but the thickness of the compact myocardium was normal in all other regions of the heart. The decreased volume and number of myocardial cells in the heart tube after neural crest ablation most likely reflects the amount of myocardium added by the secondary heart field. Development Dynamics 228:152–160, 2003. © 2003 Wiley‐Liss, Inc.
Opportunity costs calculation in agent-based vehicle routing and scheduling

In this paper we consider a real-time, dynamic pickup and delivery problem with timewindows where orders should be assigned to one of a set of competing transportation companies. Our approach decomposes the problem into a multi-agent structure where vehicle agents are responsible for the routing and scheduling decisions and the assignment of orders to vehicles is done by using a second-price auction. Therefore the system performance will be heavily dependent on the pricing strategy of the vehicle agents. We propose a pricing strategy for vehicle agents based on dynamic programming where not only the direct cost of a job insertion is taken into account, but also its impact on future opportunities. We also propose a waiting strategy based on the same opportunity valuation. Simulation is used to evaluate the benefit of pricing opportunities compared to simple pricing strategies in different market settings. Numerical results show that the proposed approach provides high quality solutions, in terms of profits, capacity utilization and delivery reliability.
The I Don't Know Option in the Vocabulary Size Test.

The current study evaluates guessing behaviors in a vocabulary size test (VST) and examines whether including an I don't know in a VST may have an impact on the results of the test. One-hundred-fifty first-year students at a university in China took part in the study. They were randomly assigned to three groups. Each group took a different version of the VST: the original VST, the VST with an I don't know option, and the VST with an I don't know option and a penalty instruction. After the VST, a reading comprehension test (used as a distraction) and a meaning recall task were administered to all participants. Comparing the results of the VST and the recall task, it was found that guessing behaviors can be influenced by factors such as vocabulary frequency level, partial knowledge, and the multiple-choice options. Results also indicate that the I don't know option not only reduced the number of guesses but also discouraged partial knowledge. Whether to include the I don't know option and the penalty instruction depends on how the test is to be used.
“Institutional Work” for What? Problems and Prospects of Institutional Theory

The problems and prospects currently facing Institutional Theory are addressed by scrutinizing recent proposals for focusing upon ‘institutional work’ in a way of that promises to overcome some limitations of its “old,” “neo,” and “entrepreneurialist” incarnations. Current proposals to pay closer attention to ‘institutional work’ are seen to reproduce the dualism of individual (agency) /institution (structure) as they invite a further flip-flop between these poles, To escape this cycle, a start can be made by incorporating into Institutional Theory a critically reflexive appreciation of the ‘individual’ as an institution. Such a move is consistent with a contemporary interest in bridging institutional and critical scholarly traditions. In constructing this bridge, the challenge is to advance scholarship in a direction that, being collaborative rather than predatory, does not obfuscate or domesticate the emancipatory intent of critical analysis.
Clinical efficacy of percutaneous renal revascularization with stent placement in atherosclerotic renovascular disease.

OBJECTIVE To evaluate the clinical efficacy of percutaneous renal revascularization with stenting to control hypertension and preserve/restore renal function in patients with atherosclerotic renovascular disease. METHODS From May/1999 to October/2003, 46 patients with atherosclerotic renal artery stenosis (ARAS) underwent revascularization with stenting. The indication for the procedure was hypertension control and/or renal function preservation/restoration. Clinical characteristics: age range: 33-84 years (median = 58.5 +/-10.7), males: 26 (56.5%), 4 (10%) patients with diabetes mellitus, 21 (46%) patients with coronary artery disease, creatinine <2.0mg/dl: 39 (64%), 6 patients (14%) with congestive heart failure, 20 (43%) patients with ostial stenosis and 15 (33%) patients with bilateral stenosis. Hypertension control was evaluated by the number of drugs used before the procedure and at follow-up (FU) and by blood pressure (BP) measurement. RESULTS The minimum follow-up was 7 months (range of 7-52, median: 23, mean: 24.2 +/- 15.2). There were no major complications. No patient experience any cardiovascular event. There was only one non-cadiac death (2%) and one technical failure in the treatment(2%). There was no serious complication in the procedure. None of the patients presented cardiovascular events. The renal function improved or stabilized in 32 patients (82%) and worsened in 4 (10%). The BP control improved in 19/44 (43,8%) patients and worsened / stabilized in 6 patients (14%). CONCLUSION Angioplasty with renal artery stenting for ARAS showed to be an effective treatment strategy to restore and preserve renal function and to control blood pressure.
A Macro Role for Microglia in Poststroke Depression

cant changes over time or differences between groups. Because most dietary calcium intake in Finland is from dairy products, it as expected that participants’ diets were also adequate in protein. Because individuals with cognitive impairment (MiniMental State Examination (MMSE) score <21) were excluded, and the mean MMSE score of the participants was high at baseline (28.3 1.5), it was not expected that the exercise intervention would improve the scores significantly. At 24 months, the mean MMSE score was 28.2 1.7, with no significant differences between groups. Because the study did not aim to improve cognition specifically, more-sophisticated methods of assessing cognition were not used. Information on polypharmacy and drugs possibly increasing the risk of falls was obtained through questionnaires at every measurement point. These variables did not differ significantly between the groups at any time point.
Managing Categorization and Social Withdrawal in Japan: Rehabilitation Process in a Private Support Group for Hikikomorians

Abstract: Social withdrawal among Japanese youth has been noticed since the latter-half of the 1990s. It is called Hikikomori in Japan. Though some clinicians in the mental health field have referred to social backgrounds of this problem, only a few sociological studies have been conducted. I have conducted participant observation in a private support group and recorded the rehabilitation processes of people with Hikikomori for two years. My study has two aspects. First, it is a short ethnography concerning the features of the group efforts. Second, it is intended to interpret relations between the features and rehabilitation processes. The first feature is the group dynamics arising from friendly and competitive relationships among the people with Hikikomori—called Hikikomorians. The second feature is “managing categorization”. It is a tendency to be vague about categories that indicate their social status accompanied with some roles. This tendency could be observed in various aspects of the group activities, for example, concerning diseases’ names, schedules, definition of space and so on. Managing categorization allows Hikikomorians to easily participate in and experience social activities. They are people who do not have social categories to explain themselves easily in social settings and do not have the self-confidence to perform some roles. Under social pressures, however, they tend to maintain a behavioral principle that is based on categories. Managing categorization therefore functions to provisionally release their attitudes and allow them to attempt trial and error based situations more easily. Finally, I also indicate some difficulties of managing categorization.
Understanding personalisation: Implications for social work

Summary This article analyses the centrality of the policy of personalisation within adult social care in the UK, with a particular focus on the implications for social work. It starts by considering the genesis of policy and continues by identifying different ways in which personalisation can be understood and hence analysed. Findings The article suggests that the dominant theme in the rhetoric of both government and the disability movement associates personalisation with the concept of social citizenship – whereby previously disadvantaged people will be enabled to enjoy the full benefits of society, which had previously been denied to them. By way of contrast, the article suggests that personalisation can also be analysed in relation to the critical perspective of neo-liberalism, postulating the idea that the policy is primarily concerned with the importation of consumerist ideals into social care. The article then considers the administrative dimensions of personalisation, focusing on the potential of the policy to achieve particular financial benefits and arguing that this is taking precedence over other interpretations. Applications The article concludes by considering the implications of the analysis for the practice of social work. It identifies the implications of the citizenship and neo-liberal perspectives, but concludes that imperatives of budgetary reduction are limiting the opportunities for social workers to practise within the context of personalisation. Consequently, while there is little prospect of substantial social work involvement in the context of statutory services, there may be opportunities for practitioners to engage with the issues in the context of smaller, often user-led organisations.
Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor

Pandemics pose a more significant threat to pregnant women than to the nonpregnant population and may have a detrimental effect on the well being of the fetus. We have developed an animal model to evaluate the consequences of a viral infection characterized by lack of fetal transmission. The experiments described in this work show that viral infection of the placenta can elicit a fetal inflammatory response that, in turn, can cause organ damage and potentially downstream developmental deficiencies. Furthermore, we demonstrate that viral infection of the placenta may sensitize the pregnant mother to bacterial products and promote preterm labor. It is critical to take into consideration the fact that during pregnancy it is not only the maternal immune system responding, but also the fetal/placental unit. Our results further support the immunological role of the placenta and the fetus affecting the global response of the mother to microbial infections. This is relevant for making decisions associated with treatment and prevention during pandemics.
Analysis of BPEL Data Dependencies

BPEL is a de-facto standard language for Web service orchestration. It is a challenge to test BPEL processes automatically because of the complex features of the language. The current formal semantics proposed for BPEL can be categorized under three branches: process algebra, Petri- nets, and automata. Our goal is to automate the generation and execution of test cases for composed Web services. Model checking is an effective technique for automated test generation, and most mature model checkers such as SPIN and NuSMV use automata as the underlying formal model. Hence, we follow the automata branch. Unfortunately, the current automata based approaches omit the BPEL data dependencies. In order to address this shortcoming, we demonstrate how to model BPEL data dependencies in our proposed Web service automata.
Windscape and tortuosity shape the flight costs of northern gannets

When animals move across a landscape, they alternate between active searching phases in areas with high prey density and commuting phases towards and in-between profitable feeding patches. Such active searching movements are more sinuous than travelling movements, and supposedly more costly in energy. Here we provide an empirical validation of this long-lasting assumption. To this end, we evaluated simultaneously energy expenditure and trajectory in northern gannets (Morus bassanus) using GPS loggers, dive recorders and three-dimensional accelerometers. Three behavioural states were determined from GPS data: foraging, when birds actively searched for prey (high tortuosity, medium speed); travelling, when birds were commuting (straight trajectory, high speed); and resting (straight trajectory, low speed). Overall dynamic body acceleration, calculated from acceleration data, was used as a proxy for energy expenditure during flight. The impact of windscape characteristics (wind force and direction) upon flight costs was also tested. Energy expenditure of northern gannets was higher during sinuous foraging flight than during more rectilinear travelling flight, demonstrating that turns are indeed costly. Yet wind force and direction also strongly shaped flight energy expenditure; within any behavioural state it was less costly to fly with the wind than against it, and less costly to fly with strong winds. Despite the major flight costs of wind action, birds did not fully optimize their flight track relative to wind direction, probably because of prey distributions relative to the coastline and wind predictability. Our study illustrates how both tortuosity and windscape shape the foraging costs of marine predators such as northern gannets.