Miracle-dz/UniFAR-FTUs huggingface dataset:
Examination of Protein Quantity and Protein Distribution across the Day on Ad Libitum Carbohydrate and Fat Intake in Overweight Women

Abstract Background: The effects of meal-specific protein quantity and protein distribution throughout the day on daily food intake are relatively unknown. Objectives: The aims were to test 1) whether the consumption of higher-protein (HP) compared with normal-protein (NP) meals consumed at each eating occasion reduce free-living, daily carbohydrate and fat intakes in overweight women during energy balance conditions and 2) whether the distribution of protein consumed throughout the day affects food intake outcomes. Methods: Seventeen women [mean ± SEM age: 33 ± 1 y; body mass index (in kg/m2): 27.8 ± 0.1] completed the following tightly controlled, crossover design study. Participants were provided with and randomly consumed three 6-d eucaloric diets containing NP or HP (15% or 25% of energy as protein, respectively). The protein content within the NP diet used an even distribution pattern (EVEN; 21 ± 1 g protein/meal) throughout the day, whereas the protein contents within the HP diets used either EVEN (35 ± 1 g protein/meal) or an uneven distribution pattern (UNEVEN; 19 ± 1 g protein/breakfast, 26 ± 1 g protein/lunch, 63 g protein/dinner). On day 7 of each diet, the participants were asked to consume the diet-specific absolute protein quantity (in grams) at each eating occasion but were provided with a surplus of carbohydrate- and fat-rich foods to consume, ad libitum, during each eating occasion. Results: Eating more protein (HP compared with NP) or evenly distributing protein throughout the day (HP-EVEN compared with HP-UNEVEN) did not reduce the consumption of ad libitum fat- and carbohydrate-rich foods throughout the day (NP-EVEN: 2850 ± 240 kcal/d; HP-EVEN: 2910 ± 240 kcal/d; HP-UNEVEN: 3160 ± 200 kcal/d). Despite the lack of differences in daily energy intake, the breakfast meal within the HP-EVEN diet led to lower ad libitum carbohydrate and fat intakes than the breakfast meals in the NP-EVEN and HP-UNEVEN diet conditions (P < 0.05). Conclusion: Providing 30 g protein/meal at each eating occasion throughout the day did not influence free-living, daily intake of highly palatable, carbohydrate- and fat-rich foods in overweight women. This trial was registered at clinicaltrials.gov as NCT02614729.
Association between Plasma Nonesterified Fatty Acids Species and Adipose Tissue Fatty Acid Composition

Fatty acid composition of adipose tissue (AT) is an established long-term biomarker for fatty acid (FA) intake and status, but AT samples are not easily available. Nonesterified FA composition in plasma (pNEFA) may be a good indicator of AT FA composition, because pNEFA are mainly generated by AT lipolysis. We investigated the correlation of 42 pNEFA and subcutaneous as well as visceral AT FA in 27 non-diabetic women with a median BMI of 36 kg/m2 (Q0.25: 25 kg/m2; Q0.75: 49 kg/m2). Close correlations of pNEFA and AT FA were found for odd-chain FA (15∶0 r = 0.838 and 0.862 for subcutaneous and visceral AT, respectively) and omega-3 FA (22∶6 r = 0.719/0.535), while no significant or low correlations were found for other FA including 18∶1 (r = 0.384/0.325) and 20∶4 (r = 0.386/0.266). Close correlations of pNEFA and AT FA were found for essential fatty acids, like 18∶2 (r = 0.541/0.610) and 20∶5 (r = 0.561/0.543). The lower correlation for some pNEFA species with AT FA indicates that the variation of most pNEFA is significantly affected by other FA sources and flux of FA to tissue, in addition to release from AT. A relevant influence of BMI on the level of correlation was shown for saturated FA. NEFA analysis in fasted plasma can serve as a virtual AT biopsy for some FA, and as a biomarker for intake of dairy products and sea fish.
Neutralizing antibodies during treatment of secondary progressive MS with interferon β-1b

Objective: To investigate the relationship between neutralizing antibodies (NAB) and disease progression, relapses, and MR measures of MS. Methods: Sequential serum samples from all 718 patients of the European Study Group in Interferon β-1b in Secondary Progressive MS were analyzed to investigate relations between NAB and disease progression, relapses, and MR measures. Results: This study showed no attenuating effect of NAB development on progression in disability. The effects of NAB on relapse rate showed substantial variation, depending on the statistical approach and definition of positivity, though analyses comparing low- and high-NAB+ periods with NAB− periods suggested a titer-related effect. MR T2 lesion volume changes from baseline were significantly higher for NAB+ patients but remained lower than for placebo patients. A substantial proportion of NAB+ patients became NAB−. No untoward effect of NAB development on safety was observed. Conclusion: These results support the conclusion that even though high NAB titers appear to have impact on treatment efficacy with respect to relapses, treatment decisions should be based primarily on clinical grounds.
Slowing Down Mobilities: Passengering on an Inter-war Ocean Liner

Abstract This article contributes to recent work on the figure of the passenger and ‘passengering’ in mobilities research. It does so by considering the experiences of one passenger over two journeys on an ocean liner undertaken in 1930. The article ‘follows’ the passenger over the course of the two journeys in order to open up the processuality of passengering. The article makes two core contributions. First, it demonstrates the need to lend attention to the specific socialities and materialities of mobile modalities that work on and form the passenger. It is shown how specific assemblages come together at sea to create atmospheres that shape the experiences of long-distance travel over water. Second, by following the passenger over the course of journeying, it demonstrates the emergence of the passenger in relation to shifting affective atmospheres, not as a static figure but one of becoming passenger, as a shifting set of subjectivities, and, in turn, shows the value of ‘following’ a journey within mobilities research.
Innovative antifibrotic therapies in systemic sclerosis

Purpose of reviewFibrosis is a key feature of systemic sclerosis (SSc) and arises from excessive release of collagens by pathologically activated fibroblasts. Affecting the skin and many internal organs, fibrosis represents a major cause for the high morbidity and mortality in SSc. So far, effective therapies to treat fibrosis in SSc and other fibrotic diseases are not available in clinical routine. Nevertheless, promising antifibrotic agents are emerging from translational studies with some having already entered clinical trials. Recent findingsIn this review, we focus on recent advances in the development of antifibrotic treatment strategies in SSc. We have selected for targeted therapeutic approaches that have proven high efficacy and tolerability in preclinical fibrosis models of SSc and/or are already in clinical evaluation. Applying these criteria, we discuss a large repertory of candidate antifibrotic therapies that block inflammatory pathways, inhibit profibrotic growth factors, modulate epigenetic signaling, and interfere with morphogenic pathways. SummaryMany antifibrotic candidate therapies have proven efficacy and tolerability in preclinical models of SSc. So far, early clinical studies have tested only few of these agents. Besides discovering novel molecular treatment strategies, SSc research will now have to translate its findings into clinical practice.
Detection of Helicobacter pylori in stomach tissue by use of a monoclonal antibody

Monoclonal antibodies were produced against an acid glycine extract of Helicobacter pylori ATCC 43504T. One of these appeared to be specific for H. pylori; it recognized all H. pylori isolates by an indirect immunofluorescence assay (IIF) but it did not cross-react with the other strains tested, including different species of the genera Helicobacter, Campylobacter, and Wolinella. Different strains of members of the families Enterobacteriaceae and Pseudomonadaceae or other gram-negative bacteria tested also gave negative reactions. Indirect immunofluorescence assay of antral biopsy specimens identified 54 of 56 infected patients (96.4%), and it may be able to detect nonviable organisms after antibiotic therapy.
Circulating Irisin Levels Are Positively Associated with Metabolic Risk Factors in Sedentary Subjects

Introduction A physically active life-style plays an independent role in the protection against type 2 diabetes and cardiovascular diseases. Irisin, a novel exercise-induced myokine, activates thermogenesis in rodents through increasing beige fat cells abundance within white fat. We aimed to investigate circulating irisin levels in association with the degree of physical activity and various metabolic parameters in humans. Methods Circulating irisin levels (ELISA) and metabolic parameters were analyzed in 428 subjects (195 men/233 women). Participants were classified according to their self-reported physical activity and to their area of residence. Results Circulating irisin levels were higher in active than in sedentary subjects (p= 0.006). Rural inhabitants showed higher circulating irisin levels than urban subjects (p < 0.0001). The increase in irisin levels related to an active lifestyle was only observed in rural citizens (p = 0.014). Among sedentary participants, irisin levels were positively associated with metabolic risk factors (BMI, fasting insulin, HOMA and fasting triglycerides). The area of residence (β= - 0.592, p= < 0.0001) contributed independently to circulating irisin levels variance after controlling for age, gender, BMI, HOMAIR, triglycerides and physical activity. Conclusions In sedentary participants, circulating irisin levels were positively associated with parameters related to an increased cardiometabolic risk. The present study confirmed that an active lifestyle increases circulating irisin levels, but only among subjects living in a rural environment. Area of residence might be a determinant of irisin levels.
Evaluation of the Quality of Semen and Sexual Function in Men with Inflammatory Bowel Disease

Background: Data on fertility rates and medication safety in men with inflammatory bowel disease (IBD) are limited. The aim of this study was to evaluate whether there is a seminal alteration in patients with IBD and, if so, to evaluate the mechanisms that may play a role according to what has been described in the literature. Its secondary aim was to evaluate the impact on male sexual function of IBD. Methods: Multicenter, cross-sectional, case series study comparing men with IBD and control subjects. Semen analysis was performed according to the recommendations of World Health Organization. The impact on male sexual function was evaluated with the International Index of Erectile Function questionnaire. Results: On multivariate analysis, patients with Crohn's disease had lower sperm concentrations compared with those with ulcerative colitis (median [interquartile range], 34.5 [19.2–48] versus 70 [34.5–127.5], P = 0.02) and lower seminal zinc levels (mean ± SD, 1475 ± 235 &mgr;mol/L versus 2221 ± 1123 &mgr;mol/L, P = 0.04). Patients with Crohn's disease on anti–tumor necrosis factor treatment had better progressive motility (mean ± SD, 56.7 ± 17.7 versus 35.1 ± 22.1, P = 0.01) and sperm morphology (14.4 ± 7.1 versus 7.6 ± 4.9, P = 0.04) than those who were not on anti–tumor necrosis factor. Regarding sexual function, no significant differences were found across patients with IBD and control subjects. Conclusions: Men with Crohn's disease showed a trend toward poorer semen quality than those with ulcerative colitis. Treatment with anti–tumor necrosis factor drugs does not seem to be associated with poor sperm quality. In patients in clinical remission, male sexual function is not affected by IBD.
When Excuses Don't Work: the Persistent Injustice Effect Among Black Managers

In this paper, we examine the underlying dynamics of the differences between blacks' and whites' responses to social accounts-explanations or excuses for negative actions and events. Across four studies we found that when black respondents observed unjust behaviors toward a hypothetical black victim, social accounts had a weak impact on perceptions of injustice, confirming the presence of what we call the persistent injustice effect. We also found that social accounts have a weaker impact on perceptions of injustice than on disapproval of the harm-doer and posit that the persistent injustice effect results from a combination of in-group identification with the victim and the respondent's personal experiences with injustice. These two factors, we theorize, combine to create greater empathy for the victim.
Leisure, coping and health: the role of social, family, school and peer relationship factors

The relationship between social, family, peer and school factors and leisure engagement within a transactional model of stress and health was investigated in 655 young adults. Results show that the family environment, encouragement from parents and teachers, relationships with peers and socioeconomic factors in childhood predict adult attitudes to and engagement in leisure. In turn, leisure attitude and engagement are related to psychological distress, optimism, perceived control and social support. It is argued that the development of patterns of leisure attitudes and engagement in childhood need to be understood in predicting and changing adult leisure behaviours relevant to health and illness.
Personal contact, individuation, and the better-than-average effect.

Research in which people compare themselves with an average peer has consistently shown that people evaluate themselves more favorably than they evaluate others. Seven studies were conducted to demonstrate that the magnitude of this better-than-average effect depends on the level of abstraction in the comparison. These studies showed that people were less biased when they compared themselves with an individuated target than when they compared themselves with a nonindividuated target, namely, the average college student. The better-than-average effect was reduced more when the observer had personal contact with the comparison target than when no personal contact was established. Differences in the magnitude of the better-than-average effect could not be attributed to the contemporaneous nature of the target's presentation, communication from the target, perceptual vividness, implied evaluation, or perceptions of similarity
Transcriptome Profiling of Testis during Sexual Maturation Stages in Eriocheir sinensis Using Illumina Sequencing

The testis is a highly specialized tissue that plays dual roles in ensuring fertility by producing spermatozoa and hormones. Spermatogenesis is a complex process, resulting in the production of mature sperm from primordial germ cells. Significant structural and biochemical changes take place in the seminiferous epithelium of the adult testis during spermatogenesis. The gene expression pattern of testis in Chinese mitten crab (Eriocheir sinensis) has not been extensively studied, and limited genetic research has been performed on this species. The advent of high-throughput sequencing technologies enables the generation of genomic resources within a short period of time and at minimal cost. In the present study, we performed de novo transcriptome sequencing to produce a comprehensive transcript dataset for testis of E. sinensis. In two runs, we produced 25,698,778 sequencing reads corresponding with 2.31 Gb total nucleotides. These reads were assembled into 342,753 contigs or 141,861 scaffold sequences, which identified 96,311 unigenes. Based on similarity searches with known proteins, 39,995 unigenes were annotated based on having a Blast hit in the non-redundant database or ESTscan results with a cut-off E-value above 10−5. This is the first report of a mitten crab transcriptome using high-throughput sequencing technology, and all these testes transcripts can help us understand the molecular mechanisms involved in spermatogenesis and testis maturation.
Do discriminatory attitudes to older workers at work affect their retirement intentions

Purpose - The purpose of this paper is to investigate whether employers’ attitudes towards older workers, especially regarding promotions, really affect their retirement intentions, distinguishing between men and women. Design/methodology/approach - First, the author uses the 1992 wave of the Health and Retirement Study to estimate, through a Fields decomposition, the relative contribution of the feeling of an older worker to be discriminated against regarding promotions; and to explain the self-reported probability to work full time after 62, decomposing by gender. Second, using the two first waves of HRS, the author removes any bias due to time-constant unobserved heterogeneity, to test whether the individual feeling of being passed over for promotion may be misreported, owing to a strong preference for leisure. Finally, the author examines the effect of a change in this variable over time on the intentions to exit early. Findings - The Fields decomposition shows that feeling passed over for promotion plays a non-negligible role to predict retirement plans but only for women. In addition, using panel data allows a misreporting bias to be exhibited that may lead to underestimating of the negative effect of discriminatory practices towards older workers on their retirement plans. Lastly, an increase between 1992 and 1994 in the age-discrimination towards older workers encouraged women to leave their job early, while it had no effect on retirement plans of men. Practical implications - Empirical results put forward the idea that retirement intentions may differ across gender, owing to the different nature of the employer-employee relation. While for men, this relation is characterized by delayed-payment arrangements signed ex ante with the employer, as already shown by Adams, it is not true for women. Consequently, the age-based preference of employers for promotion, leading to a lower probability of promotion for older workers, is treated by men as a consequence of ex ante arrangements and does not affect their retirement plans. However, women can attribute such attitudes of their employer to a kind of blatant discrimination, reducing therefore their attachment to their job. Originality/value - The paper presents a longitudinal approach towards the determinants of retirement intentions that allows the unobserved heterogeneity constant over time to be removed and to estimate to what extent the feeling of being passed over for promotion may be attributed, for each gender, to some arrangements signed ex ante with the employer.
Exchange Rate Exposure and Firm Valuation: New Evidence for Market Efficiency

Prior research on the sensitivity of firms to exchange rates has documented a puzzling result: while firm stock returns are only weakly related to contemporaneo us changes in exchange rates, they are related to lagged exchange rate changes. This result is consistent with market inefficiency since the stock market appears to respond to exchange rate changes with a delay when the predictable effects of dollar movements are confirmed in financial statements (Bartov and Bodnar, 1995). We re-examine these results for samples of net exporters and net importers, where net importers (exporters) are firms with a strong positive (negative) correlation between abnormal returns and contemporaneous exchange rate changes over the previous 20 quarters. In contrast with prior results, we find a strong relation between abnormal returns and contemporaneous exchange rate changes. We show that our result is due primarily to subsets of firms and sample periods not examined earlier; specifically, the relation is strongest for net importers (the international firms examined by others are more likely to be net exporters) and more recent years. Although we confirm the lagged relation observed by others, we document many conflicting aspects of this relationship, and hence are reluctant to interpret it as market inefficiency.
Compliance issues related to the selection of antibiotic suspensions for children

Objective. To evaluate the palatability, cost and other compliance issues as variables in the selection of antibiotic suspensions for children. Methods. Eighty-six physicians and health care personnel randomly sampled amoxicillin (used as a standard for comparison) and 11 other antibiotics, evaluating them in categories of appearance, smell, texture, taste and aftertaste. Overall scoring was then adjusted for cost, duration of therapy and dosing intervals. Results. Overall taste (palatability) ranking of antibiotics, highest to lowest, was as follows: loracarbef, cefdinir, cefixime, azithromycin, ciprofloxacin, trimethoprim-sulfamethoxazole, clarithromycin, trimethoprim, amoxicillin/clavulanate, cefpodoxime and cefuroxime. Overall rating of antibiotics was greatly influenced by other compliance variables, in order of their impact: cost; duration of therapy (5 vs. 10 days); and dosing intervals. Cost was not judged to be a major factor by most participants unless antibiotic expense was >$50.00 for treatment of otitis media in our hypothetical 2-year-old, 13-kg child. Taking all variables into consideration, final ranking from highest to lowest was azithromycin, cefdinir, loracarbef, cefixime, amoxicillin, trimethoprim-sulfamethoxazole, cefpodoxime, trimethoprim, clarithromycin, ciprofloxacin, cefuroxime and amoxicillin/clavulanate. Conclusions. Variables related to compliance for families filling antibiotic prescriptions and children taking these products are important in the selection of antimicrobial therapy. Because final assessment is likely to vary considerably among health care personnel, decisions must be made on an individual basis.
An Examination of How Academic Advancement of U.S. Journalism Students Relates to Their Degree Motivations, Values, and Technology Use

The newsroom is a powerful influence in a journalist’s identity formation. Research has yet to verify the socializing impact of academia. This research utilized the quantitative survey method applying it to undergraduate journalism students (n = 798) to assess how academic status relates to students’ degree motivations, life values, and technology use. The results show advancement is related to variations in perceptions of some degree motivations, which include perceiving journalism as a path to write and fame, but life values were not significantly different. The implication of this study suggests that academia may not have much impact on certain perceptions and behaviors.
Learning a concept-based document similarity measure

Document similarity measures are crucial components of many text-analysis tasks, including information retrieval, document classification, and document clustering. Conventional measures are brittle: They estimate the surface overlap between documents based on the words they mention and ignore deeper semantic connections. We propose a new measure that assesses similarity at both the lexical and semantic levels, and learns from human judgments how to combine them by using machine-learning techniques. Experiments show that the new measure produces values for documents that are more consistent with people's judgments than people are with each other. We also use it to classify and cluster large document sets covering different genres and topics, and find that it improves both classification and clustering performance. © 2012 Wiley Periodicals, Inc.