Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of cigarette filters on the risk of developing oral leukoplakia in a Kenyan population.

OBJECTIVE To determine the influence of cigarette filters and the effect of smoking Kiraiku (home processed, hand rolled tobacco) on the risk of developing oral leukoplakia among cigarette smokers. DESIGN Case control using population-based study groups in a Kenyan rural community. MATERIALS AND METHODS 85 cases and 141 controls identified in a cross-section house-to-house screening of subjects aged 15 years and over and matched for sex, age (+/- 3 years) and cluster origin were compared for their use of filter and non-filter cigarettes as well as their history of smoking Kiraiku. RESULTS The relative risk (RR) of oral leukoplakia was 9.1 (95% confidence intervals (CI) = 4.1-20.2) in smokers of filter cigarettes and 9.8 (95% CI = 2.3-47.0) in smokers of non-filter cigarettes. The RR in the latter compared to the former was 1.1 and was not statistically significant. Regarding the influence of smoking Kiraiku, the RR of this lesion was 29.3 in smokers of both Kiraiku and filter cigarettes and 17.3 in smokers of both Kiraiku and non-filter cigarettes. CONCLUSIONS There was no statistically significant difference between the influence of filter and non-filter cigarettes on the risk of developing oral leukoplakia. The effect of Kiraiku on the risk of this lesion was stronger in filter than in non-filter cigarettes. However, the confounding effect of tobacco dose response parameters could not be ruled out.
Mathematical Modelling of Metabolic Regulation in Aging

The underlying cellular mechanisms that characterize aging are complex and multifaceted. However, it is emerging that aging could be regulated by two distinct metabolic hubs. These hubs are the pathway defined by the mammalian target of rapamycin (mTOR) and that defined by the NAD+-dependent deacetylase enzyme, SIRT1. Recent experimental evidence suggests that there is crosstalk between these two important pathways; however, the mechanisms underpinning their interaction(s) remains poorly understood. In this review, we propose using computational modelling in tandem with experimentation to delineate the mechanism(s). We briefly discuss the main modelling frameworks that could be used to disentangle this relationship and present a reduced reaction pathway that could be modelled. We conclude by outlining the limitations of computational modelling and by discussing opportunities for future progress in this area.
ECTOPIC PANCREATIC TISSUE IN THE STOMACH: CASE REPORT

Introduction: Ectopic pancreas is a rare developmental anomaly. It is a presence of pancreatic tissue without anatomic or vascular continuity with the normally developed pancreas. The most common heterotopic site is the stomach commonly involving antrum and prepyloric region on the greater curvature or posterior wall. Ectopic pancreas is diagnosed by endoscopic ultrasound, gastroscopy and biopsy, CT scan and MRI of the abdomen, a definitive diagnosis is verified by histopathological examination. Treatment is surgical. Case report: A 56-year-old woman presented with epigastric pain, nausea and fatigue. Esophagogastroduodenoscopy showed submucosal mass in the prepyloric region, biopsy was performed. Histopathological findings described normal gastric mucosa. Endoscopic ultrasonography and CT of the abdomen showed submucosal tumor, 18 mm in diameter, located in the prepyloric region. Surgical treatment was indicated. Gastrotomy with total extraction of tumor was performed. Histopathology findings showed ectopic pancreatic tissue in the submucosal and muscular layer of the stomach. Postoperatively patient fully recovered, and in the 2 year folow-up did not develop any symptoms related to gastrointestinal tract. Conclusion: Although presentation of ectopic pancreatic tissue in stomach is a very rare condition, it should be considered during gastroitestinal diagnostic in patients with nonspecific gastrointestinal symptomatology. In most of cases, for this patients, surgery is curative and definitive solution.
Fifty Years of Artificial Reverberation

The first artificial reverberation algorithms were proposed in the early 1960s, and new, improved algorithms are published regularly. These algorithms have been widely used in music production since the 1970s, and now find applications in new fields, such as game audio. This overview article provides a unified review of the various approaches to digital artificial reverberation. The three main categories have been delay networks, convolution-based algorithms, and physical room models. Delay-network and convolution techniques have been competing in popularity in the music technology field, and are often employed to produce a desired perceptual or artistic effect. In applications including virtual reality, predictive acoustic modeling, and computer-aided design of acoustic spaces, accuracy is desired, and physical models have been mainly used, although, due to their computational complexity, they are currently mainly used for simplified geometries or to generate reverberation impulse responses for use with a convolution method. With the increase of computing power, all these approaches will be available in real time. A recent trend in audio technology is the emulation of analog artificial reverberation units, such as spring reverberators, using signal processing algorithms. As a case study we present an improved parametric model for a spring reverberation unit.
Class-Wide Curricular Modification to Improve the Behavior of Students with Emotional or Behavioral Disorders

We examined the effects of class-wide curricular modification on the engagement and challenging behaviors of students enrolled in a self-contained science class. Participants were six students between the ages of 13 and 14, all with labels of severe emotional disturbance in addition to a variety of other diagnoses. Class-wide curricular modifications consisted of providing opportunities for choice making and ensuring that activities were of high interest to students. Findings showed that the curricular modifications resulted in increased levels of engagement and decreased levels of problem behaviors. Results are discussed in the context of system-level behavior support within the school setting.
Characterization of a binding protein for leukemia inhibitory factor localized in extracellular matrix

Leukemia Inhibitory Factor (LIF) interacts with two classes of high affinity binding sites on rat UMR cells cultured in monolayer. One class of binding sites was found to be localized in the extracellular matrix (ECM) after removal of cells from the culture dish. The interaction of LIF with ECM-localized binding sites is not dependent upon either glycosylation of LIF or the presence of extracellular glycosyaminoglycans. Chemical cross-linking studies demonstrate that LIF interacts with a 200-kD cell-associated protein and a 140-kD ECM- localized protein. A 140-kD protein could also be specifically precipitated from solubilised metabolically radiolabeled UMR ECM by antibodies directed against LIF by virtue of its ability to form a stable complex with unlabeled LIF. In addition, soluble LIF associated with this ECM-localized protein is biologically active in terms of inhibition of ES cell differentiation. The properties of ECM-localized 140-kD species are very similar to those of the secreted form of the LIF receptor suggesting that the ECM localization of LIF and LIF signal transduction may be closely coupled.
Structural features of the focal adhesion kinase–paxillin complex give insight into the dynamics of focal adhesion assembly

The C‐terminal region of focal adhesion kinase (FAK) consists of a right‐turn, elongated, four‐helix bundle termed the focal adhesion targeting (FAT) domain. The structure of this domain is maintained by hydrophobic interactions, and this domain is also the proposed binding site for the focal adhesion protein paxillin. Paxillin contains five well‐conserved LD motifs, which have been implicated in the binding of many focal adhesion proteins. In this study we determined that LD4 binds specifically to only a single site between the H2 and H3 helices of the FAT domain and that the C‐terminal end of LD4 is oriented toward the H2‐H3 loop. Comparisons of chemical‐shift perturbations in NMR spectra of the FAT domain in complex with the binding region of paxillin and the FAT domain bound to both the LD2 and LD4 motifs allowed us to construct a model of FAK–paxillin binding and suggest a possible mechanism of focal adhesion disassembly.
Activation of complement by serum-resistant Neisseria gonorrhoeae. Assembly of the membrane attack complex without subsequent cell death

Interaction of the human complement system in normal human serum (NHS) with serum-resistant and -sensitive Neisseria gonorrhoeae was evaluated to better understand the mechanism of serum-resistance. Complement activity (CH50) was depleted from NHS in a dose-dependent fashion by both serum-resistant and -sensitive N. gonorrhoeae. No detectable CH50 remained in NHS incubated with 10(9) colony-forming units (CFU)/ml serum of either resistant or sensitive strains. When smaller numbers of bacteria were incubated with NHS, lesser, yet comparable, amounts of CH50 were depleted by both resistant and sensitive strains. Hemolytic C2 activity was diminished by 33% in the case of resistant N. gonorrhoeae (10(8) CFU/ml serum) and by 48% in the case of a sensitive strain. No detectable decreases in hemolytic C4 or C7 activities were found with either sensitive or resistant strains at this concentration. Both resistant and sensitive strains activated C1s in NHS. Resistant strains specifically activated 19-21% of radiolabeled C1s in NHS, whereas sensitive strains activated 18-32%. Both resistant and sensitive strains also activated C5 in NHS. In binding assays using radiolabeled C5 and C9 in NHS, resistant and sensitive strains bound comparable amounts of C5 and C9. The number of bound C5 and C9 molecules varied according to the number of bacteria or amount of serum used in the assay. The ratio of C9/C5 bound to a sensitive strain was 6.8, and to a resistant strain was 8.2, suggesting that C5 and C9 were incorporated into membrane attack complexes (MAC). Electron microscopic examination of resistant and sensitive strains incubated with NHS revealed that MAC is bound to the surfaces of the resistant strain as well as the sensitive strain.
Relations of Personality Traits and Attachment Styles with Different Aspects of Sexuality in Men and Women

Na uzorcima od 297 ispitanika muskog i 316 ženskog spola u dobi od 17 do 36 godina ispitan je odnos dimenzija petofaktorskog modela licnosti i stilova privrženosti (sigurna, odbijajuca, preokupirajuca i bojažljiva) s razlicitim aspektima seksualnosti (socioseksualnost, seksualna privlacnost, seksualna ekskluzivnost, spolna orijentacija, erotofilija, seksualna orijentacija, seksualna indiskrecija i seksualna suzdržanost) koji su zasiceni dvama faktorima visega reda nazvanima seksualni nagon i seksualna odanost. Rezultati pokazuju da se stilovi privrženosti ne mogu svesti na siroke dimenzije petofaktorskog modela, vec se radi o dvije domene koje se relativno malo preklapaju. Nadalje, crte licnosti bolje nego stilovi privrženosti prediciraju razlicite aspekte seksualnosti i kod muskaraca i kod žena. Također, crte licnosti i kod žena i kod muskaraca bolje prediciraju one aspekte seksualnosti koji se odnose na seksualni nagon nego one koji se odnose na seksualnu odanost. Pritom je posebno znacajna uloga ekstraverzije, koja je najsnažniji prediktor gotovo svih aspekata seksualnog nagona kod oba spola. Kada se pak radi o stilovima privrženosti, dobiveni rezultati pokazuju da niža odbijajuca privrženost najkonzistentnije predicira razlicite aspekte seksualnosti, a narocito seksualne odanosti kod oba spola. Sigurna privrženost pozitivan je prediktor erotofilije i seksualnog nagona, ali samo kod muskaraca, dok su preokupirajuca i bojažljiva privrženost slabo i nekonzistento povezane s razlicitim aspektima seksualnosti. Između žena i muskaraca nisu dobivene sustavne razlike u stilovima privrženosti kao prediktorima razlicitih aspekata seksualnosti. Kada se radi o crtama licnosti, otvorenost je važniji prediktor razlicitih aspekata seksualnosti kod muskaraca nego kod žena, dok kod žena važniju ulogu ima savjesnost, pogotovo pri predikciji nekih aspekata seksualne odanosti. Rezultati multidimenzionalnog skaliranja, kojim je analiziran odnos između svih ispitanih varijabli pokazuju da se temeljne osobine licnosti, stilovi privrženosti i dimenzije seksualnosti u euklidskom prostoru raspoređuju uzduž dvije dimenzije koje se mogu interpretirati u kontekstu interpersonalnih obilježja pojedinca.
Aging assessment of kraft paper insulation through methanol in oil measurement

Aging of transformer paper insulation is commonly investigated through indirect measurements conducted in the oil, e.g. furanic compounds. In addition to the conventional indicators, recent investigations showed that alcohols like methanol and ethanol in oil could be used as paper aging indicators. This paper focuses on the applicability of these new paper aging indicators in a novel, gas-to-liquid (GTL) technology based transformer oil through an accelerated laboratory aging experiment. The experiment was conducted at 120 °C for up to 280 days. A conventional mineral oil was also tested as a reference. Kraft paper aged in both oil types showed similar reductions in degree of polymerization (DP) and tensile strength (TS). Amount of methanol in oil is higher than that of 2-FAL in oil when DP is over 375, confirming the promise of using methanol as an early paper aging indicator. Both the new paper aging indicator, methanol and the conventional paper aging indicator, 2-FAL are applicable for the GTL oil without any modifications. In addition, oil only aging experiments showed that oil does produce methanol but it is negligible compared with oil paper aging experiment; however the amount of ethanol measured in the present oil paper aging experiment is believed to be originated from oil oxidation rather than from paper aging.
Pharmacological effects of Zataria multiflora Boiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects

Zataria multiflora Boiss (Z. multiflora) belongs to the Lamiaceae family is used traditionally for culinary and medicinal purposes. Different pharmacological effects have been described for the plant including; bronchodilation, vasodilation, and effect on lung inflammation. The plant is also used as a remedy against cough in the traditional medicine. In this article, ‘pharmacological effects of Z. multiflora and its constituents focusing on their anti‐inflammatory, antioxidant, and immunomodulatory properties were reviewed’ by searching various databases until ‘June’ 2016. The anti‐inflammatory effects of the plant such as decreased total white blood cell, neutrophils, and eosinophils counts were demonstrated. The sprotective effects of Z. multiflora on serum levels of phospholipase A2 and total protein were showed. In addition, constituents of the plant, such as flavonoids and carvacrol, also showed anti‐inflammatory effects. Z. multiflora also reduced oxidative stress by scavenging free radicals and can be used in the therapy of oxidative damage. Decreased level of malondialdehyde and protective effects of Z. multiflora on serum levels of nitric oxide were also shown. Improvement of the serum levels of IgE, reduction in pro‐inflammatory cytokine (IL‐4, TGF‐β, and IL‐17), and increased anti‐inflammatory cytokines (IFN‐γ and FOXP3) were shown for Z. multiflora and its constituents, carvacrol and thymol. These results indicated that carvacrol and thymol could be used for treatment of inflammatory diseases as new anti‐inflammatory agents. Therefore, Z. multiflora showed anti‐inflammatory, antioxidant, and immunomodulatory effects which could be used for treatment of inflammatory and immune dysregulation diseases or disorders associated with increased oxidative stress.
Proximity to Industrial Food Animal Production and Asthma Exacerbations in Pennsylvania, 2005–2012

The research on industrial food animal production (IFAP) and asthma exacerbations in the United States has relied on small sample sizes and/or self-reported outcomes. We assessed associations of proximity to large-scale and densely stocked swine and dairy/veal IFAP with three types of asthma exacerbations: hospitalizations, emergency encounters, and oral corticosteroid (OCS) medication orders from Geisinger Clinic in Pennsylvania. We used a diagnosis code (International Classification of Diseases, 9th Revision, Clinical Modification code 493.x) and medication orders from electronic health records to identify these exacerbations among asthma patients (n = 35,269) from 2005–2012. We compared residential proximity to swine or dairy/veal IFAP (dichotomized as <3 miles (4.8 km) or ≥3 miles) among asthma patients with and without exacerbations and estimated odds ratios using multilevel logistic regression. In adjusted models, proximity to IFAP was associated (odds ratio (95% confidence interval)) with OCS orders (1.11 (1.04–1.19)) and hospitalizations (1.29 (1.15–1.46)), but not emergency encounters (1.12 (0.91–1.37)). This study contributes to growing evidence that IFAP may impact health, in this case clinically-documented asthma exacerbations. No prior study has evaluated the association of IFAP and clinically-documented asthma exacerbations in the United States.
Consistent supersymmetric Kaluza-Klein truncations with massive modes

We construct consistent Kaluza-Klein reductions of D = 11 supergravity to four dimensions using an arbitrary seven-dimensional Sasaki-Einstein manifold. At the level of bosonic fields, we extend the known reduction, which leads to minimal N = 2 gauged supergravity, to also include a multiplet of massive fields, containing the breathing mode of the Sasaki-Einstein space, and still consistent with N = 2 supersymmetry. In the context of flux compactifications, the Sasaki-Einstein reductions are generalizations of type IIA SU(3)-structure reductions which include both metric and form-field flux and lead to a massive universal tensor multiplet. We carry out a similar analysis for an arbitrary weak G2 manifold leading to an N = 1 supergravity with massive fields. The straightforward extension of our results to the case of the seven-sphere would imply that there is a four-dimensional Lagrangian with N = 8 supersymmetry containing both massless and massive spin two fields. We use our results to construct solutions of M-theory with non-relativistic conformal symmetry.
Preoperative Radiation Therapy Followed by Reexcision May Improve Local Control and Progression-Free Survival in Unplanned Excisions of Soft Tissue Sarcomas of the Extremity and Chest-Wall

Background. The management for unplanned excision (UE) of soft tissue sarcomas (STS) has not been established. In this study, we compare outcomes of UE versus planned excision (PE) and determine an optimal treatment for UE in STS. Methods. From 2000 to 2014 a review was performed on all patients treated with localized STS. Clinical outcomes including local recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) were evaluated using the Kaplan-Meier estimate. Univariate (UVA) and multivariate (MVA) analyses were performed to determine prognostic variables. For MVA, Cox proportional hazards model was used. Results. 245 patients were included in the analysis. 14% underwent UE. Median follow-up was 2.8 years. The LR rate was 8.6%. The LR rate in UE was 35% versus 4.2% in PE patients (p < 0.0001). 2-year PFS in UE versus PE patients was 4.2 years and 9.3 years, respectively (p = 0.08). Preoperative radiation (RT) (p = 0.01) and use of any RT for UE (p = 0.003) led to improved PFS. On MVA, preoperative RT (p = 0.04) and performance status (p = 0.01) led to improved PFS. Conclusions. UEs led to decreased LC and PFS versus PE in patients with STS. The use of preoperative RT followed by reexcision improved LC and PFS in patients who had UE of their STS.
Canine Babesiosis in Northwestern India: Molecular Detection and Assessment of Risk Factors

In the current study, a total of 214 blood samples from dogs in and around Ludhiana, Punjab (India), suspected for canine babesiosis were examined with conventional and molecular assays. Examination of Giemsa-stained peripheral thin blood smears revealed an overall prevalence of 7.47% (16/214) for canine babesiosis encompassing 0.93% (2/214) of large Babesia and 6.54% (14/214) of Babesia gibsoni. However, molecular diagnosis revealed 15.42% (33/214) samples positive for B. gibsoni infection as evident by the presence of 671 bp amplicon. The results of multivariate analysis showed that the prevalence of B. gibsoni was associated with various risk factors, namely, age (P < 0.001; OR: 0.398; CI 95%: 0.080–1.799), sex (P = 0.022; OR: 0.849; CI 95%: 0.403–1.791), breed of host (P = 0.371; OR: 3.345; CI 95%: 1.045–10.710), and season (P = 0.230; OR: 2.143; CI 95%: 0.788–5.830). The prevalence of B. gibsoni was higher in summer as compared to winter season and in younger dogs, while breed and sex of the host were not significantly associated with the occurrence of the disease.
Methodology for determining doses to in-field, out-of-field and partially in-field organs for late effects studies in photon radiotherapy

An important but little examined aspect of radiation dosimetry studies involving organs outside the treatment field is how to assess dose to organs that are partially within a treatment field; this question is particularly important for studies intended to measure total absorbed dose in order to predict the risk of radiogenic late effects, such as second cancers. The purpose of this investigation was therefore to establish a method to categorize organs as in-field, out-of-field or partially in-field that would be applicable to both conventional and modern radiotherapy techniques. In this study, we defined guidelines to categorize the organs based on isodose inclusion criteria, developed methods to assess doses to partially in-field organs, and then tested the methods by applying them to a case of intensity-modulated radiotherapy for hepatocellular carcinoma based on actual patient data. For partially in-field organs, we recommend performing a sensitivity test to determine whether potential inaccuracies in low-dose regions of the DVH (from the treatment planning system) have a substantial effect on the mean organ dose, i.e. >5%. In such cases, we suggest supplementing calculated DVH data with measured dosimetric data using a volume-weighting technique to determine the mean dose.
Variable response of cholinesterase activities following human exposure to different types of organophosphates

We investigated the red blood cell (RBC) acetylcholinesterase (AChE) activities and butyrylcholinesterase (BChE) activities at presentation to the emergency department (ED) and at 24 h after presentation following poisoning by dichlorvos, fenitrothion, or ethyl p-nitrophenol thio-benzene phosphonate (EPN). Although the patients from different groups had similar characteristics at presentation such as time interval from ingestion to presentation to the ED and the amount of organophosphate ingested, the dichlorvos group had significantly lower BChE levels than the fenitrothion group and lower RBC cholinesterase activity than the EPN group. Patients poisoned with EPN or dichlorvos had significantly higher inhibition of BChE activities from baseline than RBC AChE activities at presentation. Twenty four hours after administration of pralidoxime, RBC AChE activities had increased in patients in the dichlorvos and EPN groups, while RBC AChE activities had slightly decreased in the fenitrothion group. BChE activities increased significantly in the dichlorvos group but decreased in the EPN group. The recovery patterns of RBC AChE and BChE activities did not match in any particular individual. This study showed that the patterns of inhibition and recovery of the activities of two cholinesterases after treatment are highly variable according to the organophosphate and in different individuals.