Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient policies for carrying Web traffic over flow-switched networks

To efficiently transfer diverse traffic over high-speed links, modern integrated networks require more efficient packet-switching techniques that can capitalize on the advances in switch hardware. Several promising approaches attempt to improve the performance by creating dedicated "shortcut" connections for long-lived traffic flows, at the expense of the network overhead for establishing and maintaining these shortcuts. The network can balance these cost-performance tradeoffs through three tunable parameters: the granularity of flow end-point addresses, the timeout for grouping related packets into flows, and the trigger for migrating a long-lived flow to a shortcut connection. Drawing on a continuous one-week trace of Internet traffic, we evaluate the processor and switch overheads for transferring HTTP server traffic through a flow-switched network. In contrast to previous work, we focus on the full probability distributions of flow sizes and cost-performance metrics to highlight the subtle influence of the HTTP protocol and user behavior on the performance of flow switching. We find that moderate levels of aggregation and triggering yield significant reductions in overhead with a negligible reduction in performance. The traffic characterization results further suggest schemes for limiting shortcut overhead by temporarily delaying the creation of shortcuts during peak load and by aggregating related packets that share a portion of their routes through the network.
Fast Approximate Discovery of Inclusion Dependencies

: Inclusion dependencies (INDs) are relevant to several data management tasks, such as foreign key detection and data integration, and their discovery is a core concern of data proﬁling. However, n -ary IND discovery is computationally expensive, so that existing algorithms often perform poorly on complex datasets. To this end, we present F ���� , the ﬁrst approximate IND discovery algorithm. F ���� combines probabilistic and exact data structures to approximate the INDs in relational datasets. In fact, F ���� guarantees to ﬁnd all INDs and only with a low probability false positives might occur due to the approximation. This little inaccuracy comes in favor of signiﬁcantly increased performance, though. In our evaluation, we show that F ���� scales to very large datasets and outperforms the state-of-the-art algorithm by a factor of up to six in terms of runtime without reporting any false positives. This shows that F ���� strikes a good balance between e � ciency and correctness.
Four Sub-Saturns with Dissimilar Densities: Windows into Planetary Cores and Envelopes

We present results from a Keck/HIRES radial velocity campaign to study four sub-Saturn-sized planets, K2-27b, K2-32b, K2-39b, and K2-108b, with the goal of understanding their masses, orbits, and heavy-element enrichment. The planets have similar sizes ( = 4.5–5.5 ), but have dissimilar masses ( = 16–60 ), implying a diversity in their core and envelope masses. K2-32b is the least massive ( ) and orbits in close proximity to two sub-Neptunes near a 3:2:1 period commensurability. K2-27b and K2-39b are significantly more massive at and , respectively, and show no signs of additional planets. K2-108b is the most massive at , implying a large reservoir of heavy elements of about ≈50 . Sub-Saturns as a population have a large diversity in planet mass at a given size. They exhibit remarkably little correlation between mass and size; sub-Saturns range from ≈6–60 , regardless of size. We find a strong correlation between planet mass and host star metallicity, suggesting that metal-rich disks form more massive planet cores. The most massive sub-Saturns tend to lack detected companions and have moderately eccentric orbits, perhaps as a result of a previous epoch of dynamical instability. Finally, we observe only a weak correlation between the planet envelope fraction and present-day equilibrium temperature, suggesting that photo-evaporation does not play a dominant role in determining the amount of gas sub-Saturns accrete from their protoplanetary disks.
An Assessment of Swash Excursion Predictors using Field Observations

ABSTRACT Passarella, M. ; De Muro, S. ; Ruju, A. , and Coco, G. , 2018. An assessment of swash excursion predictors using field observations. In: Shim, J.-S. ; Chun, I. , and Lim, H.S. (eds.), Proceedings from the International Coastal Symposium (ICS) 2018 (Busan, Republic of Korea). Journal of Coastal Research, Special Issue No. 85, pp. 1036–1040. Coconut Creek (Florida), ISSN 0749-0208. Accurate predictions of swash excursion are fundamental for improving the understanding of swash zone dynamics and for coastal management and hazard applications. Researchers have provided several formulas for predicting the swash excursion on sandy beaches. However, the problem of the universality of these formulas is still open. In fact, it is not clear whether the existing formulations are applicable to a wide range of beaches and wave conditions. This study verifies 13 existing swash (total, incident and infragravity) formulations using 13 published experiments (636 swash measurements). The experiments were carried out on beaches worldwide (dissipative intermediate and reflective) under a wide range of wave conditions (including extreme events). Results show that formulas behave differently with under and over prediction. However, some trends can be recognized, which are indeed critical for coastal hazards and management applications: generally, for large swash events (swash >1.5 m) large scatter are found for all formulas. During extreme conditions (swash>2.5 m) total and incident swash are strongly underestimated, while infragravity swash varies for each formula. The maximum errors and the root mean square errors can exceed 2.5 m and 1 m, respectively.
On the Optimality of Planar and Geometric Approximation Schemes

We show for several planar and geometric problems that the best known approximation schemes are essentially optimal with respect to the dependence on epsi. For example, we show that the 2<sup>O(1/epsi)</sup>ldrn time approximation schemes for planar maximum independent set and for TSP on a metric defined bv a planar graph are essentially optimal: if there is a delta>0 such that any of these problems admits a 2<sup>O((1/epsi)</sup> <sup>1-delta</sup> <sup>)</sup>n<sup>O(1)</sup> time PTAS, then the exponential tune hypothesis (ETH) fails. It is known that maximum independent set on unit disk graphs and the planar logic problems MPSAT. TMIN, TMAX admit n<sup>O(1/epsi)</sup> time approximation schemes. We show that they are optimal in the sense that if there is a delta>0 such that any of these problems admits a 2<sup>(1/epsi)</sup> <sup>O(1)</sup> n<sup>O((1/epsi)</sup> <sup>1-delta</sup> <sup>)</sup> time PTAS, then ETH fails.
Identification and Characterization of T5-Like Bacteriophages Representing Two Novel Subgroups from Food Products

During recent years, interest in the use of bacteriophages as biocontrol agents against foodborne pathogens has increased, particularly for members of the family Enterobacteriaceae, with pathogenic Escherichia coli, Shigella, and Salmonella strains among them. Here, we report the isolation and characterisation of 12 novel T5-like bacteriophages from confiscated food samples. All bacterophages effectively lysed E. coli K-12 strains and were able to infect pathogenic E. coli strains representing enterohaemorrhagic (EHEC), enteropathogenic (EPEC), enterotoxigenic (ETEC), and enteroinvasive (EIEC) pathotypes, Shigella dysenteriae, S. sonnei strains, as well as multidrug-resistant (MDR) E. coli and multiple strains representing different Salmonella enterica serovars. All the bacteriophages exhibited Siphoviridae morphology. Whole genome sequencing of the novel T5-like bacteriophages showed that they represent two distinct groups, with the genome-based grouping correlating to the different host spectra. As these bacteriophages are of food origin, their stability and lack of any virulence genes, as well as their broad and mutually complementary host spectrum makes these new T5-like bacteriophages valuable candidates for use as biocontrol agents against foodborne pathogenic enterobacteria.
Pose estimation for category specific multiview object localization

We propose an approach to overcome the two main challenges of 3D multiview object detection and localization: The variation of object features due to changes in the viewpoint and the variation in the size and aspect ratio of the object. Our approach proceeds in three steps. Given an initial bounding box of fixed size, we first refine its aspect ratio and size. We can then predict the viewing angle, under the hypothesis that the bounding box actually contains an object instance. Finally, a classifier tuned to this particular viewpoint checks the existence of an instance. As a result, we can find the object instances and estimate their poses, without having to search over all window sizes and potential orientations. We train and evaluate our method on a new object database specifically tailored for this task, containing real-world objects imaged over a wide range of smoothly varying viewpoints and significant lighting changes. We show that the successive estimations of the bounding box and the viewpoint lead to better localization results.
Flavopiridol Induces Gj Arrest with Inhibition of Cyclin-dependent Kinase ( CDK ) 2 and CDK 4 in Human Breast Carcinoma Cells

Flavopiridol (L86-8275), a JV-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G, or G2 and is a potent cyclin-dependent kinase (CDK) 1 inhibitor. In this study, we used MCF-7 breast carcinoma cells that are wild type for p53 and pRb positive and contain CDK4-cycIin Dl and MDA-MB-468 breast carcinoma cells that are mutant p53, pRb negative, and lack CDK4-cyclin Dl to investigate the G, arrest produced by Flavopiridol. Recombinant CDK4-cyclin Dl was inhibited potently by Flavopiridol (Kitfp, 65 nM), competitive with respect to ATP. Surprisingly, CDK4 immunoprecipitates derived from Flavopiridol-treated MCF-7 cells (3 h, 300 nM Flavopiridol) had an approximately 3-fold increased kinase activity compared with untreated cells. Cyclin D and CDK4 levels were not different at 3 h, but cyclin D levels and CDK4 kinase activity decreased thereafter. The phosphorylation state of pRb was shifted from hypercoincident to hypocoincident with the development of G, arrest. Asynchronous MDA-MB-468 cells were inhibited in cell cycle progression at both G, and G2 by Flavopiridol. Flavopiridol inhibited the in vitro kinase activity of CDK2 using an immune complex kinase assay (ICSO, 100 nM at 400 fiM ATP). Immunoprecipitated CDK2 kinase activity from either MCF-7 or MDA-MB-468 cells exposed to Flavopiridol (300 nM) for increasing time showed an initial increased activity (approximate ly 1.5-fold at 3 h) compared with untreated cells, followed by a loss of kinase activity to immeasurable levels by 24 h. This increased immunoprecipitated kinase activity was dependent on the Flavopiridol concentra tion added to intact cells and was associated with a reduction of CDK2 tyrosine phosphorylation. Cyclin E and A levels were not altered to the same extent as cyclin D, and neither CDK4 nor CDK2 levels were changed in response to Flavopiridol. Inhibition of the CDK4 and/or CDK2 kinase activity by Flavopiridol can therefore account for the G! arrest observed after exposure to Flavopiridol.
Disentangling the effects of historic vs. contemporary landscape structure on population genetic divergence

Increasing habitat fragmentation poses an immediate threat to population viability, as gene flow patterns are changed in these altered landscapes. Patterns of genetic divergence can potentially reveal the impact of these shifts in landscape connectivity. However, divergence patterns not only carry the signature of altered contemporary landscapes, but also historical ones. When considered separately, both recent and historical landscape structure appear to significantly affect connectivity among 51 wood frog (Rana sylvatica) populations. However, by controlling for correlations among landscape structure from multiple time periods, we show that patterns of genetic divergence reflect recent landscape structure as opposed to landscape structure prior to European settlement of the region (before 1850s). At the same time, within‐population genetic diversities remain high and a genetic signature of population bottlenecks is lacking. Together, these results suggest that metapopulation processes – not drift‐induced divergence associated with strong demographic bottlenecks following habitat loss – underlie the strikingly rapid consequences of temporally shifting landscape structure on these amphibians. We discuss the implications of these results in the context of understanding the role of population demography in the adaptive variation observed in wood frog populations.
Cardiac vagal response to water ingestion in normal human subjects.

In healthy young subjects there is direct evidence for sympathetic vasoconstrictor activation after drinking water, but this is not accompanied by an increase in arterial blood pressure. A marked pressor response to water ingestion has, however, been observed in elderly subjects and in patients with autonomic failure. We examined the effect of water ingestion on haemodynamic variables and heart rate variability (HRV) markers of cardiac vagal control in ten healthy young subjects and four cardiac transplant recipients with confirmed persistent cardiac vagal denervation. In a random order crossover protocol, changes in heart rate, blood pressure and measures of high frequency (HF) HRV were compared over time following the ingestion of 500 ml and 20 ml (control) of tap water. In healthy subjects, after drinking 500 ml of water the heart rate fell from 67.6+/-2.0 (mean+/-S.E.M.) to 60.7+/-2.4 beats/min (P<0.01), and the bradycardic response peaked between 20 and 25 min. There were no significant changes in arterial blood pressure. Over the same time course, water ingestion caused increases in measurements of HF HRV: root-mean-square of successive RR interval differences (RMSSD) increased by 13+/-2.7 ms after 500 ml versus 2+/-3.1 ms after 20 ml (P<0.05); HF power increased by 686+/-400 versus -63+/-322 (P<0.01). In transplant recipients water ingestion was followed by a pressor response (range 13 to 29 mmHg). These results provide evidence that water ingestion in normal subjects is followed by an increase in cardiac vagal control that may counteract the pressor effects of sympathetic activation. We suggest that in the elderly, in transplant recipients and in autonomic failure, loss of this buffering mechanism explains the pressor response to drinking water.
N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion

Iron is critical for cellular proliferation and its depletion leads to a suppression of both DNA synthesis and global translation. These observations suggest that iron depletion may trigger a cellular “stress response”. A canonical response of cells to stress is the formation of stress granules, which are dynamic cytoplasmic aggregates containing stalled pre-initiation complexes that function as mRNA triage centers. By differentially prioritizing mRNA translation, stress granules allow for the continued and selective translation of stress response proteins. Although the multi-subunit eukaryotic initiation factor 3 (eIF3) is required for translation initiation, its largest subunit, eIF3a, may not be essential for this activity. Instead, eIF3a is a vital constituent of stress granules and appears to act, in part, by differentially regulating specific mRNAs during iron depletion. Considering this, we investigated eIF3a’s role in modulating iron-regulated genes/proteins that are critically involved in proliferation and metastasis. In this study, eIF3a was down-regulated and recruited into stress granules by iron depletion as well as by the classical stress-inducers, hypoxia and tunicamycin. Iron depletion also increased expression of the metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), and a known downstream repressed target of eIF3a, namely the cyclin-dependent kinase inhibitor, p27kip1. To determine if eIF3a regulates NDRG1 expression, eIF3a was inducibly over-expressed or ablated. Importantly, eIF3a positively regulated NDRG1 expression and negatively regulated p27kip1 expression during iron depletion. This activity of eIF3a could be due to its recruitment to stress granules and/or its ability to differentially regulate mRNA translation during cellular stress. Additionally, eIF3a positively regulated proliferation, but negatively regulated cell motility and invasion, which may be due to the eIF3a-dependent changes in expression of NDRG1 and p27kip1 observed under these conditions.
Role of Protein A in the Evasion of Host Adaptive Immune Responses by Staphylococcus aureus

ABSTRACT Heritable defects in human B cell/antibody development are not associated with increased susceptibility to Staphylococcus aureus infection. Protein A (SpA), a surface molecule of S. aureus, binds the Fcγ domain of immunoglobulin (Ig) and cross-links the Fab domain of VH3-type B cell receptors (IgM). Here we generated S. aureus spa variants harboring amino acid substitutions at four key residues in each of the five Ig-binding domains of SpA. Wild-type S. aureus required SpA binding to Ig to resist phagocytosis and SpA-mediated B cell receptor cross-linking to block antibody development in mice. The spaKKAA mutant, which cannot bind Ig or IgM, was phagocytosed and elicited B cell responses to key virulence antigens that protected animals against lethal S. aureus challenge. The immune evasive attributes of S. aureus SpA were abolished in µMT mice lacking mature B cells and antibodies. Thus, while wild-type S. aureus escapes host immune surveillance, the spaKKAA variant elicits adaptive responses that protect against recurrent infection. IMPORTANCE Staphylococcus aureus causes recurrent skin and bloodstream infections without eliciting immunity. Heritable defects in neutrophil and T cell function, but not B cell or antibody development, are associated with increased incidence of S. aureus infection, and efforts to develop antibody-based S. aureus vaccines have thus far been unsuccessful. We show here that the Fcγ and VH3-type Fab binding activities of staphylococcal protein A (SpA) are essential for S. aureus escape from host immune surveillance in mice. The virulence attributes of SpA in mice required mature B cells and immunoglobulin. These results suggest that antibodies and B cells play a key role in the pathogenesis of staphylococcal infections and provide insights into the development of a vaccine against S. aureus. Staphylococcus aureus causes recurrent skin and bloodstream infections without eliciting immunity. Heritable defects in neutrophil and T cell function, but not B cell or antibody development, are associated with increased incidence of S. aureus infection, and efforts to develop antibody-based S. aureus vaccines have thus far been unsuccessful. We show here that the Fcγ and VH3-type Fab binding activities of staphylococcal protein A (SpA) are essential for S. aureus escape from host immune surveillance in mice. The virulence attributes of SpA in mice required mature B cells and immunoglobulin. These results suggest that antibodies and B cells play a key role in the pathogenesis of staphylococcal infections and provide insights into the development of a vaccine against S. aureus.
Matrix metalloproteinase‐7 and matrix metalloproteinase‐25 in oral tongue squamous cell carcinoma

Predicting the clinical course of early‐stage oral tongue squamous cell carcinoma (SCC) is challenging. As matrix metalloproteinases (MMPs) are enzymes associated with invasion, metastasis, and poor survival in many cancers, we examined MMP‐7 and MMP‐25 in oral tongue SCC.
Sex-specific associations of moderate and vigorous physical activity with physical fitness in adolescents

Abstract The present study examined the sex-specific associations of moderate and vigorous physical activity (VPA) with physical fitness in 300 Japanese adolescents aged 12–14 years. Participants were asked to wear an accelerometer to evaluate physical activity (PA) levels of various intensities (i.e. moderate PA (MPA), 3–5.9 metabolic equivalents (METs); VPA, ≥6 METs; moderate to vigorous PA (MVPA), ≥3 METs). Eight fitness items were assessed (grip strength, bent-leg sit-up, sit-and-reach, side step, 50 m sprint, standing long jump, handball throw, and distance running) as part of the Japanese standardised fitness test. A fitness composite score was calculated using Japanese fitness norms, and participants were categorised according to their score from category A (most fit) to category E (least fit), with participants in categories D and E defined as having low fitness. It was found that for boys, accumulating more than 80.7 min/day of MVPA may reduce the probability of low fitness (odds ratio (ORs) [95% confidence interval (CI)] = 0.17 [0.06–0.47], p = . 001). For girls, accumulating only 8.4 min of VPA could reduce the likelihood of exhibiting low fitness (ORs [95% CI] = 0.23 [0.05–0.89], p = .032). These results reveal that there are sex-specific differences in the relationship between PA and physical fitness in adolescents, suggesting that sex-specific PA recommendation may be needed to improve physical fitness in adolescents.
A Contingent Resource-Based View of Proactive Corporate Environmental Strategy

We integrate perspectives from the literature on contingency, dynamic capabilities, and the natural resource-based view of the firm to propose how dimensions of the general competitive environment of a business will influence the development of a dynamic, proactive corporate strategy for managing the business–natural environment interface. We also explain how certain characteristics of the general business environment—uncertainty, complexity, and munificence—moderate the relationship between the dynamic capability of a proactive environmental strategy and competitive advantage. We conclude with a discussion of implications for research and practice.
Asymmetric Deep Supervised Hashing

Hashing has been widely used for large-scale approximate nearest neighbor search because of its storage and search efficiency. Recent work has found that deep supervised hashing can significantly outperform non-deep supervised hashing in many applications. However, most existing deep supervised hashing methods adopt a symmetric strategy to learn one deep hash function for both query points and database (retrieval) points. The training of these symmetric deep supervised hashing methods is typically time-consuming, which makes them hard to effectively utilize the supervised information for cases with large-scale database. In this paper, we propose a novel deep supervised hashing method, called asymmetric deep supervised hashing (ADSH), for large-scale nearest neighbor search. ADSH treats the query points and database points in an asymmetric way. More specifically, ADSH learns a deep hash function only for query points, while the hash codes for database points are directly learned. The training of ADSH is much more efficient than that of traditional symmetric deep supervised hashing methods. Experiments show that ADSH can achieve state-of-the-art performance in real applications.