Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy and safety of oral tranexamic acid in total knee arthroplasty

Background: Tranexamic acid (TXA) is an antifibrinolytic drug widely used as a blood-sparing technique in total knee arthroplasty (TKA), and it is usually administrated by intravenous or intraarticular injection. Recently, the oral form of TXA has been applied in TKA patients. However, there is no final consensus regarding the effectiveness and safety of oral TXA. The purpose of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to evaluate the efficacy and safety of oral TXA versus control for blood loss after TKA. Methods: We searched PubMed, Embase, Medline, Web of Science, and Cochrane Library databases for relevant studies through August 2017. The mean difference (MD) of total blood loss, hemoglobin (Hb) drop, hematocrit (Hct), drain output, and risk difference (RD) of transfusion rate and thromboembolic complications in the TXA and control groups were pooled throughout the study. The outcomes were pooled by Stata 12.0. Results: A total of 5 RCTs (608 patients) were included in this study. All the included studies were randomized and the quality of included studies was relatively high. The pooled results indicated that the oral TXA group had significantly less Hb drop (standardized mean difference [SMD], −0.936; 95% confidence intervals [CI], −1.118,−0.754), Hct drop (SMD, −0.693; 95% CI, −1.113, −0.274), and drain output (SMD, −0.793; 95% CI, −0.959, −0.628) than the control group. No statistically significant differences were found in transfusion rate and the incidence of thromboembolic complications between the 2 groups. Total blood loss could not be evaluated for the insufficient date. Conclusions: Our meta-analysis suggested that the administration of oral TXA provided significantly better results with respect to Hb drop, Hct drop, and drain output without increasing the transfusion rate and the risk of thromboembolic complications after TKA. Nevertheless, our current study with some limitations such as the small sample size only provided limited quality of evidence, confirmation from further meta-analysis with large-scale, well-designed RCTs is required.
Rapid Determination of Oxygen Saturation and Vascularity for Cancer Detection

A rapid heuristic ratiometric analysis for estimating tissue hemoglobin concentration and oxygen saturation from measured tissue diffuse reflectance spectra is presented. The analysis was validated in tissue-mimicking phantoms and applied to clinical measurements in head and neck, cervical and breast tissues. The analysis works in two steps. First, a linear equation that translates the ratio of the diffuse reflectance at 584 nm and 545 nm to estimate the tissue hemoglobin concentration using a Monte Carlo-based lookup table was developed. This equation is independent of tissue scattering and oxygen saturation. Second, the oxygen saturation was estimated using non-linear logistic equations that translate the ratio of the diffuse reflectance spectra at 539 nm to 545 nm into the tissue oxygen saturation. Correlations coefficients of 0.89 (0.86), 0.77 (0.71) and 0.69 (0.43) were obtained for the tissue hemoglobin concentration (oxygen saturation) values extracted using the full spectral Monte Carlo and the ratiometric analysis, for clinical measurements in head and neck, breast and cervical tissues, respectively. The ratiometric analysis was more than 4000 times faster than the inverse Monte Carlo analysis for estimating tissue hemoglobin concentration and oxygen saturation in simulated phantom experiments. In addition, the discriminatory power of the two analyses was similar. These results show the potential of such empirical tools to rapidly estimate tissue hemoglobin in real-time spectral imaging applications.
Frontalis Muscle Asymmetry and Lateral Landmarks

Purpose: To investigate frontalis muscle asymmetry and characterize its lateral interdigitation with the orbicularis oculi muscle. Methods: After making a mid-coronal incision and bluntly dissecting to the orbital rim, the frontalis muscle was exposed, marked, and photographed. The right and left muscle bellies were analyzed and compared in both pixels and cm2 ratios generated with NIH ImageJ software. A ratio of ≥1.5 was considered significantly asymmetric. The lateral interdigitation of the frontalis and orbicularis oculi muscles was measured from the supraorbital notch with a metric ruler. Data were analyzed using 2-sample t tests, paired t tests, log scales, and nonparametric tests were performed for sensitivity analyses. A p value of ⩽0.05 was considered statistically significant. Results: Fifty-eight hemifaces of 29 Caucasian cadavers were studied for muscle belly asymmetry. Thirty-six hemifaces of 18 Caucasian cadavers (9 males) were dissected for lateral landmarks and average age of these specimens was 73 years (range: 35–91 years). Significant asymmetry in muscle belly area was found in 6/29 (20%) specimens, with the right muscle belly larger in all 6 specimens. On average, the right muscle belly area was 1.23 times that of the left (p = <0.001). The average frontalis-orbicularis interdigitation occurred 3.4 cm lateral to the supraorbital notch. Conclusions: Significant frontalis muscle belly asymmetry exists in 20% of Caucasians cadavers. The right muscle belly was larger on average and in all cases of significant asymmetry. The frontalis muscle interdigitates with the orbicularis oculi on average 3.4 cm lateral to the supraorbital notch.
Mode II Critical Stress Intensity Factor of Medium-Density Fiberboard Measured by Asymmetric Four-Point Bending Tests and Analyses of Kink Crack Formation

Using medium-density fiberboard specimens, asymmetric four-point bending tests were conducted to obtain the Mode II critical stress intensity factor for this in-plane system. Because the medium-density fiberboard is in-plane quasi-isotropic about its board plane, the crack propagates obliquely with respect to the initial crack direction under the asymmetric four-point loading condition. A finite element analysis is required to obtain the Mode II stress intensity factor. The analysis herein was conducted to take into account the kink crack formation. In addition, a three-point bend end-notched flexure test was also conducted, and the results obtained by the experiments and numerical calculations were compared. When the initial crack’s length-to-specimen’s depth ratio ranged from 0.85 to 0.95 and when the additional crack length was taken into account, the Mode II critical stress intensity factor KIIc was appropriately obtained by the asymmetric four-point bending test.
Bone Age Determination of Epiphyseal Union Around Wrist Joint and its Correlation with Chronological Age: A Radiological Study in a Jordanian Population

Age determination is one of the most important parameters for human identification. Radiographic changes during epiphyseal union provide an important means to estimate the age of adolescent and young adult skeletons. This study aims to investigate the relationship between stage of epiphyseal union at the wrist joint and chronological age in a Jordanian population. The study was carried out in a total of 101 antero-posterior radiographs of healthy subjects (45 girls and 56 boys) aging from 12 to 22 years. The obtained results from the radiographs enrolled in the current study revealed that the complete union of lower end of radius is seen at 20-21 years. The complete union of lower end of ulna is seen at 20-21 years. Females were consistently developing epiphyseal union at a younger age than their male counterparts, with a two years difference. The results suggested that the ages of epiphyseal union are found to vary greatly all over the world indicating the need for separate standards of ages of epiphyseal union for separate regions.
IMMUMNOLOGICAL EFFECTS OF AN ECHINACEA PURPUREA EXTRACT IN PATIENTS WITH BREAST CANCER

Summary Echinacea extracts have been applied for immunostimulation for many years. The clinical application though is based mainly on delivered practical experiences rather than on the results of clinical studies. Since the cell-mediated immune response is controlled by a variety of soluble cytokines, the measurement of these substances may be a means for determining the cellular immunological potential. The current report focuses on the measurement of ex vivo cytokine production of patients treated orally with an aqueous extract from Echinacea purpurea in order to evaluate the alteration of immunological parameters during the treatment. 115 patients aged between 32 and 73 years, were entered into the study after a curative treatment of breast cancer. These patients were randomised in three groups: Group I: no therapy (n=35), Group II: therapy with 8 ml Echinacea extract daily for 3 weeks (n=43) and Group III: therapy with 24 ml Echinacea extract daily for 3 weeks (n=37). From all patients heparinized blood was taken at days 0, 14 and 21. For cell culture the blood was stimulated with PHA at 10 µg/ml or PWM at 5 µg/ml for 2 days. In the supernatants the levels of the cytokines IL1-alpha IL6, IFN-gamma and TNF-alpha were determined by ELISA. Plasma levels of soluble cytokine receptors for IL2 and TNF were determined by ELISA. Measurement of the ex vivo leukocyte cytokine production in the blood cell cultures of the patients of Group II revealed a slight, yet not significant increase of IFN-gamma between day 1 and day 21 in comparison to the control group without treatment. In the blood cell cultures of the patients treated with 24 ml Echinacea extract daily a significant increase of IL1-alpha, IFN- TNF-alpha TNFp55 receptor could be observed between day 1 and day 21. From these results it can be concluded that orally applied Echinacea seems to have a dose- dependent immunostimulatory effect on monocytes and lymphocytes.
The associations of body composition and anthropometric measures with carotid intima-media thickness in obese and non-obese schoolchildren: A possible predictor for cardiovascular diseases

Background Increased carotid intima-media thickness is one of the predictors of future cardiovascular diseases. However, it is still unknown which body composition parameter or anthropometric measure is the best predictor for carotid intima-media thickness change among children and young adolescents. Objective To investigate the associations of body composition and anthropometric measures with carotid intima-media thickness among a group of obese and normal bodyweight schoolchildren. Methods A total of 125 schoolchildren (10–15 years) were recruited from four public schools in Amman, Jordan. Of them, 60 (29 boys and 31 girls) were normal bodyweight students and 65 (35 boys and 30 girls) were obese students. Anthropometric measures, fat mass and fat-free mass were determined. Carotid intima-media thickness of the common artery was measured using high-resolution B-mode ultrasound. Results Compared to normal bodyweight students, obese participants exhibited greater carotid intima-media thickness (mm) (0.45 ± 0.10 vs. 0.38 ± 0.08, p = 0.002) and fat-free mass (kg) (48.01 ± 11.39 vs. 32.65 ±7.65, p < 0.001). Pearson’s correlation coefficient and linear regression analysis revealed significant associations (p≤0.05) between mean carotid intima-media thickness and body mass index, waist circumference, hip circumference, waist-to-hip ratio, fat mass and fat-free mass. Stepwise linear regression analysis revealed that waist circumference was the only measure that was statistically significant (p ≤ 0.05) with mean carotid intima-media thickness (r2 = 0.129, p = 0.002). Conclusions Obesity is related to greater carotid intima-media thickness and other cardiovascular risk factors among schoolchildren. Waist circumference is more sensitive in predicting increased carotid intima-media thickness than other body composition or anthropometric measures. Waist circumference measurement in the analysis of future studies assessing the cardiovascular risk among obese children is warranted.
Relationships between the evaporative stress index and winter wheat and spring barley yield anomalies in the Czech Republic

There is a growing demand for timely, spatially distributed information regarding crop condition and water use to inform agricultural decision making and yield forecasting efforts. Thermal infrared remote sensing of land-surface temperature has proven valuable for mapping evapotranspiration (ET) and crop stress from field to global scales using energy balance models. This is because canopy temperature is strongly regulated by the transpiration flux, which is reduced under stress conditions. This study investigates the utility of an evaporative stress index (ESI), computed using the thermal-based Atmosphere–Land Exchange Inverse (ALEXI) surface energy balance model, for explaining yield variability over the Czech Republic for the period 2002−2014. ESI timeseries, representing standardized anomalies in the actual-to-reference ET ratio and an indicator of vegetation health, are compared with yield data collected for winter wheat and spring barley crops in 32 agricultural districts, comprising a range of climatic conditions within the Czech Republic. Correlations between ESI and yield anomalies vary with climatic region, with strongest correlations identified in the more drought-prone South Moravian districts and weaker relationships in the wetter highlands regions. In most regions, correlations with spring barley yield anomalies exceeded performance for winter wheat. For both crops, correlations peaked during the 1 to 2 mo period prior to the nominal harvest date. These results provide guidance for effective integration of remotely sensed moisture stress indicators within operational yield forecasting systems.
Meaning in Life as Comprehension, Purpose, and Mattering: Toward Integration and New Research Questions

To advance meaning in life (MIL) research, it is crucial to integrate it with the broader meaning literature, which includes important additional concepts (e.g., meaning frameworks) and principles (e.g., terror management). A tripartite view, which conceptualizes MIL as consisting of 3 subconstructs—comprehension, purpose, and mattering—may facilitate such integration. Here, we outline how a tripartite view may relate to key concepts from within MIL research (e.g., MIL judgments and feelings) and within the broader meaning research (e.g., meaning frameworks, meaning making). On the basis of this framework, we review the broader meaning literature to derive a theoretical context within which to understand and conduct further research on comprehension, purpose, and mattering. We highlight how future research may examine the interrelationships among the 3 MIL subconstructs, MIL judgments and feelings, and meaning frameworks.
Evolutionary History of Bacteriophages in the Genus Paraburkholderia

The genus Paraburkholderia encompasses mostly environmental isolates with diverse predicted lifestyles. Genome analyses have shown that bacteriophages form a considerable portion of some Paraburkholderia genomes. Here, we analyzed the evolutionary history of prophages across all Paraburkholderia spp. Specifically, we investigated to what extent the presence of prophages and their distribution affect the diversity/diversification of Paraburkholderia spp. , as well as to what extent phages coevolved with their respective hosts. Particular attention was given to the presence of CRISPR-Cas arrays as a reflection of past interactions with phages. We thus analyzed 36 genomes of Paraburkholderia spp. , including those of 11 new strains, next to those of three Burkholderia species. Most genomes were found to contain at least one full prophage sequence. The highest number was found in Paraburkholderia sp. strain MF2-27; the nine prophages found amount to up to 4% of its genome. Among all prophages, potential moron genes (e.g., DNA adenine methylase) were found that might be advantageous for host cell fitness. Co-phylogenetic analyses indicated the existence of complex evolutionary scenarios between the different Paraburkholderia hosts and their prophages, including short-term co-speciation, duplication, host-switching and phage loss events. Analysis of the CRISPR-Cas systems showed a record of diverse, potentially recent, phage infections. We conclude that, overall, different phages have interacted in diverse ways with their Paraburkholderia hosts over evolutionary time.
Health care practitioners’ perceptions of psychogenic nonepileptic seizures: A systematic review of qualitative and quantitative studies

A recent systematic synthesis of qualitative research demonstrated that patients with psychogenic nonepileptic seizures (PNES) often experience unsatisfactory encounters with health care practitioners (HCPs). It is important to understand such interactions from the perspective of those responsible for delivering care. This systematic review aimed to examine the attitudes and perceptions of HCPs toward PNES. A systematic search of 3 databases (Web of Science, PubMed, and CINAHL) was conducted in November 2017. Studies from around the world published after 1997 using qualitative or quantitative methodologies were reviewed. An interpretative stance was taken to analyze the data utilizing a grounded theory approach. The quality of studies included was assessed using the Mixed Methods Appraisal Tool. Overall, 30 separate studies capturing the views of at least 3900 professionals were included. Five concepts emerged from the analysis: (1) HCPs’ responses demonstrated uncertainty about many aspects of PNES, including diagnosis and treatment; (2) HCPs understood PNES in dualistic terms, perceiving the condition as largely associated with psychological factors; (3) Patients with PNES were considered challenging and frustrating; (4) HCPs held mixed or contested views about who is responsible for treating patients with PNES; and (5) PNES was viewed as less severe or disabling than epilepsy and associated with a greater degree of volition. Although some HCPs have an excellent understanding of PNES, the views of many give rise to concern. The number of qualitative studies that directly ask HCPs about their perceptions of PNES is limited. Moreover, some professional groups (ie, mental health specialists) are underrepresented in current research. This study reveals a demand for additional training. However, effort is needed also to change the attitudes of some practitioners toward PNES.
Aperture-Radiated Electromagnetic Field Synthesis in Complex Environments via Narrow-Waisted Gabor-Discretized Gaussian Beams

Abstract This review deals with the utility, scope, performance, and range of validity of the discretized Gabor-based, quasi-ray, narrow-waisted (NW) Gaussian beam (GB) algorithm for the analysis and synthesis of high frequency time-harmonic as well as short-pulse transient electromagnetic wavefields in the presence of complex propagation and scattering environments. Restricting attention here primarily to two-dimensional (2-D) fields and physical configurations, applications include phased and focused truncated plane-aperture-generated illumination of layered dielectrics, moderately rough air-soil interfaces, and buried objects in rough-surface-bounded halfspaces in forward scattering scenarios, as well as rough interface profile reconstruction and buried-target imaging from sparse data in inverse scattering scenarios. The role of the Gabor-based NW-GB algorithm as a computationally efficient physically incisive analytic forward solver in these applications is emphasized. Current status is reviewed and assessed in detail, with brief discussion of plans for future extensions, and of recently developed alternative methodologies.
Isolation and identification of molds and yeasts in medombae, a rice wine starter culture from Kompong Cham Province, Cambodia

Royal University of Agriculture, Phnom Penh, Cambodia Institute of Food Science and Technology, College of Agriculture, University of the Philippines Los Baños, College, Laguna – 4031, Philippines The National Institute of Molecular Biology and Biotechnology (BIOTECH), University of the Philippines Los Baños, College, Laguna – 4031, Philippines Institute of Human Nutrition and Food, College of Human Ecology, University of the Philippines Los Baños, College, Laguna – 4031, Philippines
“That British Sound”: Talk of Nationalness in Global Capitalism

This article proposes the concept of “nationalness” to account for the persistent circulation of national labels as a tool of distinction. We argue that the concept expands on the traditional conception of nation as country of origin to include cultural notions of sensuous and aesthetic qualities that are semiotically tied to national “essence. ” Nationalness connects products to nations not only through indexicality but also iconicity. It is made possible through “rhematization,” the process of appropriating signs whose interpretants are taken to be iconic. Talk of nationalness enables consumers to make sense of national labels in today’s world where the both ends of capitalism—manufacturing and consumption—are thoroughly global. Instead of confining our analytical focus to top-down national branding projects, we examine how consumers invoke the idea of a nation to describe their uses of industrial products. Our case study is the popular concept of “British sound” circulated among audiophiles. Drawing on online discussions of an internet community, the article shows that audiophiles refer to Britishness as a key mechanism to distinguish their consumption experiences from mass market consumption. We further show how the label “British sound” can be used to describe the experiences of consumer products that are no longer manufactured in Britain.
Identification of Polycomb Group Protein EZH2-Mediated DNA Mismatch Repair Gene MSH2 in Human Uterine Fibroids

Uterine fibroids (UFs) are benign smooth muscle neoplasms affecting up to 70% of reproductive age women. Treatment of symptomatic UFs places a significant economic burden on the US health-care system. Several specific genetic abnormalities have been described as etiologic factors of UFs, suggesting that a low DNA damage repair capacity may be involved in the formation of UF. In this study, we used human fibroid and adjacent myometrial tissues, as well as an in vitro cell culture model, to evaluate the expression of MutS homolog 2 (MSH2), which encodes a protein belongs to the mismatch repair system. In addition, we deciphered the mechanism by which polycomb repressive complex 2 protein, EZH2, deregulates MSH2 in UFs. The RNA expression analysis demonstrated the deregulation of MSH2 expression in UF tissues in comparison to its adjacent myometrium. Notably, protein levels of MSH2 were upregulated in 90% of fibroid tissues (9 of 10) as compared to matched adjacent myometrial tissues. Human fibroid primary cells treated with 3-deazaneplanocin A (DZNep), chemical inhibitor of EZH2, exhibited a significant increase in MSH2 expression (P < .05). Overexpression of EZH2 using an adenoviral vector approach significantly downregulated the expression of MSH2 (P < .05). Chromatin immunoprecipitation assay demonstrated that enrichment of H3K27me3 in promoter regions of MSH2 was significantly decreased in DZNep-treated fibroid cells as compared to vehicle control. These data suggest that EZH2-H3K27me3 regulatory mechanism dynamically changes the expression levels of DNA mismatch repair gene MSH2, through epigenetic mark H3K27me3. MSH2 may be considered as a marker for early detection of UFs.