Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Tempo on the Timing of Simple Musical Rhythms

We investigated whether and how the timing of musical rhythms changes with tempo. Twelve skilled pianists played a monophonic eight-bar melody in 21 different rhythmic versions at four different tempi. Within bars, the rhythms represented two isochronous patterns and all possible ordered pairs and triplets of different note values with ratios from the set {3, 2, 1}. The three-note rhythms also occurred in each of two meters (3/4 and 6/8). Significant deviations from the notated interval ratios were observed in performances of most rhythms, even at the slowest tempo. The observed ratios of the two-note rhythms changed little with tempo. By contrast, those of the three-note rhythms showed increasing assimilation of the two longer intervals as tempo increased, while the relative duration of the short interval was barely affected by tempo. These results replicate previous findings of Fraisse (1956), obtained in a nonmetrical and non-musical context. At fast tempi, the distinction between three different interval durations seems difficult to maintain.
Endogenous Mortality, Human Capital and Endogenous Growth

We consider growth and welfare effects of lifetime-uncertainty in an economy with human capital-led endogenous growth. We argue that lifetime uncertainty reduces private incentives to invest in both physical and human capital. Using an overlapping generations framework with finite-lived households we analyze the relevance of government expenditure on health and education to counter such growth-reducing forces. We focus on three different models that differ with respect to the mode of financing of education: (i) both private and public spending, (ii) only public spending, and (iii) only private spending. Results show that models (i) and (iii) outperform model (ii) with respect to long-term growth rates of per capita income, welfare levels and other important macroeconomic indicators. Theoretical predictions of model rankings for these macroeconomic indicators are also supported by observed stylized facts.
Excitotoxic Lesions of the Amygdala Fail to Produce Impairment in Visual Learning for Auditory Secondary Reinforcement But Interfere with Reinforcer Devaluation Effects in Rhesus Monkeys

Aspiration lesions of the amygdala were found previously to produce a severe impairment in visual discrimination learning for auditory secondary reinforcement in rhesus monkeys (Gaffan and Harrison, 1987). To determine whether excitotoxic amygdala lesions would also produce this effect, we trained four naive rhesus monkeys on the same task. The monkeys were required to learn 40 new visual discrimination problems per session in a situation in which visual choices were guided by an auditory secondary reinforcer that had been previously associated with food reward. Bilateral excitotoxic lesions of the amygdala had no effect on the rate of learning visual discrimination problems for auditory secondary reinforcement. We also tested the amygdalectomized monkeys on a reinforcer devaluation task and compared their performance with a group of three normal monkeys. The monkeys first learned to discriminate 60 pairs of objects, baited with two different food rewards. Each of the food rewards was then devalued by selective satiation in two separate experimental sessions. Normal controls tended to avoid displacing objects that covered the devalued food to a significantly greater degree than did the amygdalectomized monkeys, indicating that the excitotoxic amygdala damage interfered with reinforcer devaluation effects. Our results are consistent with the idea that the amygdala is necessary for learning the association between stimuli and the value of particular food rewards; however, the amygdala is not necessary for maintaining the value of secondary reinforcers, once they have been learned.
An efficient nonlinear model-predictive eco-cruise control for electric vehicles

A nonlinear problem formulation of an energy-saving model-predictive eco-cruise controller for electric vehicles is presented. With regard to the intended application in real-world tests, the model has to include the specific properties of a serial electric vehicle such as energy-recovery and a discontinuous accelerator input giving rise to a binary control variable. These specific features and the nonlinearity of the system dynamics make it a challenging task to formulate the optimisation problem in a way that allows a fast computation in real-time application. The challenges are addressed by using a model of the vehicle dynamics that is formulated in terms of the vehicle position instead of time and by considering the kinetic energy instead of the velocity. Furthermore, various constraints on the input and state variables are introduced for a realistic representation of the vehicle characteristics. A special focus is put on the treatment of a binary input variable in the optimisation. Here, in order to avoid a mixed-integer formulation of the problem, a continuous variable is introduced which is forced to take only discrete values by a penalty term. Finally, first simulation results underline the feasibility of this control approach.
Numerical modelling of gamma radiation from galaxy clusters

We investigate the spatial and spectral properties of non-thermal emission from clusters of galaxies at γ-ray energies. We estimate the radiation flux between 10 keV and 10 TeV due to inverse-Compton (IC) emission, π 0 -decay and non-thermal bremsstrahlung (NTB) from cosmic ray (CR) ions and electrons accelerated at cosmic shocks as well as secondary e = generated in inelastic p-p collisions. We identify two main region of production of non-thermal radiation, namely the core (also bright in the thermal X-ray range) and the outskirts region where accretion shocks occur. We find that IC emission from shock-accelerated CR electrons dominate the emission at the outer regions of galaxy clusters, provided that at least a fraction of a per cent of the shock ram pressure is converted into CR electrons. A clear detection of this component and of its spatial distribution will allow us to probe the cosmic accretion shocks directly. In the cluster core, γ-ray emission above 100 MeV is dominated by the π 0 -decay mechanism. At lower energies, IC emission from secondary e ′ takes over. However, IC emission from shock-accelerated electrons projected on to the cluster core will not be negligible. We emphasize the importance of separating the aforementioned emission components for a correct interpretation of the experimental data and outline a strategy for that purpose. Failure to addresses this issue will produce unsound estimates of the intracluster magnetic field strength and CR ion content. According to our estimate future spaceborne and ground-based γ-ray facilities should be able to measure the whole non-thermal spectrum both in the cluster core and at its outskirts. The importance of such measurements in advancing our understanding of non-thermal processes in the intracluster medium is discussed.
Constraints on Off-Axis Gamma-Ray Burst Jets in Type Ibc Supernovae from Late-Time Radio Observations

It has been suggested that the peculiar properties of the luminous Type Ic supernova SN 1998bw and its low-energy gamma-ray burst GRB 980425 may be understood if they originated in a standard gamma-ray burst explosion viewed far from the axis of the relativistic jet. In this scenario, strong radio emission is predicted from the jet on a timescale 1-10 yr after the explosion as it decelerates and spreads into our line of sight. To test this hypothesis, we have carried out late-time radio observations of SN 1998bw at t = 5.6 yr, yielding upper limits that are consistent with the continued fading of the supernova. We find these limits to be consistent with an off-axis jet only if the progenitor mass-loss rate is ≲ 4 × 10-7 M☉ yr-1 (for a wind velocity vw = 1000 km s-1) or the fraction of the shock energy in magnetic fields is ϵB ≲ 10-3. These values are low relative to those inferred for cosmological gamma-ray bursts. We combine the SN 1998bw measurements with existing observations for a sample of 15 local Type Ibc supernovae to estimate that at most 6% produce collimated, relativistic outflows.
Entropy-Enthalpy Compensation May Be a Useful Interpretation Tool for Complex Systems Like Protein-DNA Complexes: An Appeal to Experimentalists

In various chemical systems enthalpy-entropy compensation (EEC) is a well-known rule of behavior, although the physical roots of it are still not completely understood. It has been frequently questioned whether EEC is a truly physical phenomenon or a coincidence due to trivial mathematical connections between statistical-mechanical parameters - or even simpler: A phantom effect resulting from the misinterpretation of experimental data. Here, we review EEC from a new standpoint using the notion of correlation which is essential for the method of factor analysis, but is not conventional in physics and chemistry. We conclude that the EEC may be rationalized in terms of hidden (not directly measurable with the help of the current experimental set-up) but physically real factors, implying a Carnot-cycle model in which a micro-phase transition (MPT) plays a crucial role. Examples of such MPTs underlying physically valid EEC should be typically cooperative processes in supramolecular aggregates, like changes of structured water at hydrophobic surfaces, conformational transitions upon ligand-biopolymer binding, and so on, so forth. The MPT notion could help rationalize the occurrence of EEC in connection with hydration and folding of proteins,enzymatic reactions, functioning of molecular motors, DNA de- and rehybridization, as well as similar phenomena.
Semiclassical string solutions on 1/2 BPS geometries

We study semiclassical string solutions on the 1/2 BPS geometry of type-IIB string theory characterized by concentric rings on the boundary plane. We consider both folded rotating strings carrying nonzero R-charge and circular pulsating strings. We find that unlike rotating strings, as far as circular pulsating strings are concerned, the dynamics remains qualitatively unchanged when the concentric rings replace AdS5 × S5. Using the gravity dual we have also studied the Wilson loop of the corresponding gauge theory. The result is qualitatively the same as that in AdS5 × S5 in the global coordinates where the corresponding gauge theory is defined on S3 × R. We show that there is a correction to 1/L leading order behavior of the potential between external objects.
Calibration and accuracy testiing of mobile phone cameras

This paper examines the potential of mobile phones to be used as a front-end sensor for photogrammetric procedures and applications. For this purpose we are currently calibrating various mobile phones over our indoor 3D testfield, using self-calibration. Using the same testfield we are performing accuracy tests in order to evaluate the metric performance. This paper reports about first experiences in calibration and accuracy validation of mobile phone cameras.
Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma

Although the colorectal adenoma-to-carcinoma sequence represents a classical cancer progression model, the evolution of the mutational landscape underlying this model is not fully understood. In this study, we analyzed eight synchronous pairs of colorectal high-grade adenomas and carcinomas, four microsatellite-unstable (MSU) and four -stable (MSS) pairs, using whole-exome sequencing. In the MSU adenoma-carcinoma pairs, we observed no subclonal mutations in adenomas that became fixed in paired carcinomas, suggesting a ‘parallel’ evolution of synchronous adenoma-to-carcinoma, rather than a ‘stepwise’ evolution. The abundance of indel (in MSU and MSS pairs) and microsatellite instability (in MSU pairs) was noted in the later adenoma- or carcinoma-specific mutations, indicating that the mutational processes and functional constraints operative in early and late colorectal carcinogenesis are different. All MSU cases exhibited clonal, truncating mutations in ACVR2A, TGFBR2, and DNA mismatch repair genes, but none were present in APC or KRAS. In three MSS pairs, both APC and KRAS mutations were identified as both early and clonal events, often accompanying clonal copy number changes. An MSS case uniquely exhibited clonal ERBB2 amplification, followed by APC and TP53 mutations as carcinoma-specific events. Along with the previously unrecognized clonal origins of synchronous colorectal adenoma-carcinoma pairs, our study revealed that the preferred sequence of mutational events during colorectal carcinogenesis can be context-dependent.
Nonredundant Roles of Src-Family Kinases and Syk in the Initiation of B-Cell Antigen Receptor Signaling

When a BCR on a mature B cell is engaged by its ligand, the cell becomes activated, and the Ab-mediated immune response can be triggered. The initiation of BCR signaling is orchestrated by kinases of the Src and Syk families. However, the proximal BCR-induced phosphorylation remains incompletely understood. According to a model of sequential activation of kinases, Syk acts downstream of Src family kinases (SFKs). In addition, signaling independent of SFKs and initiated by Syk has been proposed. Both hypotheses lack sufficient evidence from relevant B cell models, mainly because of the redundancy of Src family members and the importance of BCR signaling for B cell development. We addressed this issue by analyzing controlled BCR triggering ex vivo on primary murine B cells and on murine and chicken B cell lines. Chemical and Csk-based genetic inhibitor treatments revealed that SFKs are required for signal initiation and Syk activation. In addition, ligand and anti-BCR Ab–induced signaling differ in their sensitivity to the inhibition of SFKs.
Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways

Background Gene expression alterations have previously been associated with type 2 diabetes, however whether these changes are primary causes or secondary effects of type 2 diabetes is not known. As healthy first degree relatives of people with type 2 diabetes have an increased risk of developing type 2 diabetes, they provide a good model in the search for primary causes of the disease. Methods/Principal Findings We determined gene expression profiles in skeletal muscle biopsies from Caucasian males with type 2 diabetes, healthy first degree relatives, and healthy controls. Gene expression was measured using Affymetrix Human Genome U133 Plus 2.0 Arrays covering the entire human genome. These arrays have not previously been used for this type of study. We show for the first time that genes involved in insulin signaling are significantly upregulated in first degree relatives and significantly downregulated in people with type 2 diabetes. On the individual gene level, 11 genes showed altered expression levels in first degree relatives compared to controls, among others KIF1B and GDF8 (myostatin). LDHB was found to have a decreased expression in both groups compared to controls. Conclusions/Significance We hypothesize that increased expression of insulin signaling molecules in first degree relatives of people with type 2 diabetes, work in concert with increased levels of insulin as a compensatory mechanism, counter-acting otherwise reduced insulin signaling activity, protecting these individuals from severe insulin resistance. This compensation is lost in people with type 2 diabetes where expression of insulin signaling molecules is reduced.
Changes in excitability and accommodation of human motor axons following brief periods of ischaemia.

1. The mechanism of post‐ischaemic ectopic impulse generation in nerve is not known, and previous measurements of excitability changes in human motor axons have appeared to conflict. We have used automatic threshold tracking and different stimulus‐response combinations to follow the effects on excitability of brief (5‐10 min) periods of ischaemia, too short to induce motor fasciculations. Excitability changes have been compared at different sites in axons innervating hand, arm and foot muscles. 2. Threshold was determined as the percutaneous stimulus current required to excite a single motor unit, or to evoke a constant multiunit response, after rectifying and integrating the electromyogram (EMG). Three different waveforms of stimulus current were compared: short (less than or equal to 2 ms) pulses, long (100‐200 ms) pulses to measure rheobase, and 100 ms current ramps. We also measured accommodation by recording the effects of subthreshold depolarizing currents on excitability. 3. Ischaemic and post‐ischaemic excitability changes were greatest in the proximal parts of the longest motor axons, and greater if the sphygmomanometer cuff was inflated over, rather than proximal to, the stimulating site. 4. Using integrated EMG responses from abductor digiti minimi, the ulnar nerve stimulated above the elbow became rapidly much less excitable after ischaemia when tested with short pulses, but more excitable when tested with current ramps. The rheobase rose briefly, but then fell, often below resting level, always staying below the pulse and ramp thresholds. 5. The latency of the response to a rheobasic stimulus altered in parallel with the threshold to short current pulses, and increased dramatically after ischaemia. This latency increase was associated with a prolonged phase of ‘negative accommodation’, i.e. the continued increase in excitability to a maintained subthreshold depolarizing current. 6. Changes in excitability and accommodation similar to those occurring after ischaemia were recorded following high frequency trains of stimuli. They were attributed primarily to hyperpolarization by the electrogenic sodium pump, since comparable changes could be induced by passing a steady hyperpolarizing current through the stimulating electrode. 7. Threshold and latency recordings from single motor units during and after ischaemia resembled in most respects the multiunit responses, but single unit rheobase did not show a post‐ischaemic fall below the resting level. Repetitive firing contributed to the low multiunit thresholds recorded with long current pulses during the post‐ischaemic period. 8. We conclude that human motor nerves become simultaneously both more and less excitable than normal after 10 min of ischaemia, depending on the choice of stimulus and response. (ABSTRACT TRUNCATED AT 400 WORDS)
Predictability of UK Stock Returns by Using Debt Ratios

The purpose of this study is to examine the ability of debt ratios in predicting company performance and stock returns in the long run. The U.K. companies included in the FTSE-350 index for the past ten years constitute our sample. We rank the companies according to the degree of leverage that they have. Then we examine the predictive ability of the debt burden for shareholder wealth by investigating the cumulative abnormal returns and buy and hold returns in the long-run for a holding period of three years. The results show that companies with moderately low leverage yield buy and hold abnormal returns of up to 20% in three years.
Prevalence and Genetic Analysis of Bitter Taste Perception for Phenylthiocarbamide (PTC) Among Some Muslim Populations of Uttar Pradesh, India

Abstract Background The ability to taste Phenylthiocarbamide (PTC), a bitter organic compound, described as a bimodal autosomal trait is widely used to know the heritable trait in both genetic and anthropological studies. The present study was carried out to analyze the prevalence of PTC taste sensitivity and to determine the gene frequencies among some Muslim populations of Uttar Pradesh, India. This study has some physiological relevance to highlight the adaptability of endogamous groups to behavioral traits in the same place. Methods Unrelated, healthy individuals of both sexes (Male-403, Female-418) belonging to different populations of Uttar Pradesh, India were randomly selected with the age range of 16-45 years observed for phenylthiocarbamide to taste sensitivity. PTC tasting ability was measured by using a serial dilution method of Harris and Kalmus. Results The phenotypic frequency of tasters was higher as compared to non-tasters, and the same is statistically significant (χ2= 11.92, df = 5, P = 0.036). There were more females among tasters (67.94%) than males (64.76%). This observation was statistically significant (χ2 = 14.79, df = 5, P = 0.011). Conclusion The frequency of PTC tasters is greater than non-tasters and the females have lower non-taster pheno-types as compared to males. This type of study will provide background information about genetic structure of population and serves as useful interaction of genetics, food preferences and dietary patterns.
Impact of Westernized Diet on Gut Microbiota in Children on Leyte Island

Urbanization has changed life styles of the children in some towns and cities on Leyte island in the Philippines. To evaluate the impact of modernization in dietary habits on gut microbiota, we compared fecal microbiota of 7 to 9-year-old children from rural Baybay city (n = 24) and urban Ormoc city (n = 19), and assessed the correlation between bacterial composition and diet. A dietary survey indicated that Ormoc children consumed fast food frequently and more meat and confectionary than Baybay children, suggesting modernization/westernization of dietary habits. Fat intake accounted for 27.2% of the total energy intake in Ormoc children; this was remarkably higher than in their Baybay counterparts (18.1%) and close to the upper limit (30%) recommended by the World Health Organization. Their fecal microbiota were analyzed by high-throughput 16S rRNA gene sequencing in conjunction with a dataset from five other Asian countries. Their microbiota were classified into two enterotype-like clusters with the other countries’ children, each defined by high abundance of either Prevotellaceae (P-type) or Bacteroidaceae (BB-type), respectively. Baybay and Ormoc children mainly harbored P-type and BB-type, respectively. Redundancy analysis showed that P-type favored carbohydrates whereas BB-type preferred fats. Fat intake correlated positively with the Firmicutes-to-Bacteroidetes (F/B) ratio and negatively with the relative abundance of the family Prevotellaceae/genus Prevotella. A species-level analysis suggested that dietary fat positively correlated with an Oscillibacter species as well as a series of Bacteroides/Parabacteroides species, whereas dietary carbohydrate positively correlated with Dialister succinatiphilus known as succinate-utilizing bacteria and some succinate-producing species of family Prevotellaceae, Veillonellaceae, and Erysipelotrichaceae. We also found that a Succinivibrio species was overrepresented in the P-type community, suggesting the syntroph via hydrogen and succinate. Predicted metagenomics suggests that BB-type microbiota is well nourished and metabolically more active with simple sugars, amino acids, and lipids, while P-type community is more involved in digestion of complex carbohydrates. Overweight and obese children living in Ormoc, who consumed a high-fat diet, harbored microbiota with higher F/B ratio and low abundance of Prevotella. The altered gut microbiota may be a sign of a modern diet-associated obesity among children in developing areas.