Miracle-dz/UniFAR-FTUs huggingface dataset:
Hybrid Pulling/Pushing for I/O-Efficient Distributed and Iterative Graph Computing

Billion-node graphs are rapidly growing in size in many applications such as online social networks. Most graph algorithms generate a large number of messages during iterative computations. Vertex-centric distributed systems usually store graph data and message data on disk to improve scalability. Currently, these distributed systems with disk-resident data take a push-based approach to handle messages. This works well if few messages reside on disk. Otherwise, it is I/O-inefficient due to expensive random writes. By contrast, the existing memory-resident pull-based approach individually pulls messages for each vertex on demand. Although it can be used to avoid disk operations regarding messages, expensive I/O costs are incurred by random and frequent access to vertices. This paper proposes a hybrid solution to support switching between push and pull adaptively, to obtain optimal performance for distributed systems with disk-resident data in different scenarios. We first employ a new block-centric technique (b-pull) to improve the I/O-performance of pulling messages, although the iterative computation is vertex-centric. I/O costs of data accesses are shifted from the receiver side where messages are written/read by push to the sender side where graph data are read by b-pull. Graph data are organized by clustering vertices and edges to achieve high I/O-efficiency in b-pull. Second, we design a seamless switching mechanism and a prominent performance prediction method to guarantee efficiency when switching between push and b-pull. We conduct extensive performance studies to confirm the effectiveness of our proposals over existing up-to-date solutions using a broad spectrum of real-world graphs.
Kernel Cross-Correlator

Cross-correlator plays a significant role in many visual perception tasks, such as object detection and tracking. Beyond the linear cross-correlator, this paper proposes a kernel cross-correlator (KCC) that breaks traditional limitations. First, by introducing the kernel trick, the KCC extends the linear cross-correlation to non-linear space, which is more robust to signal noises and distortions. Second, the connection to the existing works shows that KCC provides a unified solution for correlation filters. Third, KCC is applicable to any kernel function and is not limited to circulant structure on training data, thus it is able to predict affine transformations with customized properties. Last, by leveraging the fast Fourier transform (FFT), KCC eliminates direct calculation of kernel vectors, thus achieves better performance yet still with a reasonable computational cost. Comprehensive experiments on visual tracking and human activity recognition using wearable devices demonstrate its robustness, flexibility, and efficiency. The source codes of both experiments are released at https://github.com/wang-chen/KCC.
An Accelerated Method for Derivative-Free Smooth Stochastic Convex Optimization

We consider an unconstrained problem of minimizing a smooth convex function which is only available through noisy observations of its values, the noise consisting of two parts. Similar to stochastic optimization problems, the first part is of stochastic nature. The second part is additive noise of unknown nature, but bounded in absolute value. In the two-point feedback setting, i.e. when pairs of function values are available, we propose an accelerated derivative-free algorithm together with its complexity analysis. The complexity bound of our derivative-free algorithm is only by a factor of $\sqrt{n}$ larger than the bound for accelerated gradient-based algorithms, where $n$ is the dimension of the decision variable. We also propose a non-accelerated derivative-free algorithm with a complexity bound similar to the stochastic-gradient-based algorithm, that is, our bound does not have any dimension-dependent factor except logarithmic. Notably, if the difference between the starting point and the solution is a sparse vector, for both our algorithms, we obtain a better complexity bound if the algorithm uses an $1$-norm proximal setup, rather than the Euclidean proximal setup, which is a standard choice for unconstrained problems
Role of Magnesium in Vitamin D Activation and Function

Abstract Nutrients usually act in a coordinated manner in the body. Intestinal absorption and subsequent metabolism of a particular nutrient, to a certain extent, is dependent on the availability of other nutrients. Magnesium and vitamin D are 2 essential nutrients that are necessary for the physiologic functions of various organs. Magnesium assists in the activation of vitamin D, which helps regulate calcium and phosphate homeostasis to influence the growth and maintenance of bones. All of the enzymes that metabolize vitamin D seem to require magnesium, which acts as a cofactor in the enzymatic reactions in the liver and kidneys. Deficiency in either of these nutrients is reported to be associated with various disorders, such as skeletal deformities, cardiovascular diseases, and metabolic syndrome. It is therefore essential to ensure that the recommended amount of magnesium is consumed to obtain the optimal benefits of vitamin D.
Single Image Super-Resolution via Cascaded Multi-Scale Cross Network

The deep convolutional neural networks have achieved significant improvements in accuracy and speed for single image super-resolution. However, as the depth of network grows, the information flow is weakened and the training becomes harder and harder. On the other hand, most of the models adopt a single-stream structure with which integrating complementary contextual information under different receptive fields is difficult. To improve information flow and to capture sufficient knowledge for reconstructing the high-frequency details, we propose a cascaded multi-scale cross network (CMSC) in which a sequence of subnetworks is cascaded to infer high resolution features in a coarse-to-fine manner. In each cascaded subnetwork, we stack multiple multi-scale cross (MSC) modules to fuse complementary multi-scale information in an efficient way as well as to improve information flow across the layers. Meanwhile, by introducing residual-features learning in each stage, the relative information between high-resolution and low-resolution features is fully utilized to further boost reconstruction performance. We train the proposed network with cascaded-supervision and then assemble the intermediate predictions of the cascade to achieve high quality image reconstruction. Extensive quantitative and qualitative evaluations on benchmark datasets illustrate the superiority of our proposed method over state-of-the-art super-resolution methods.
Measurements of dermal uptake of nicotine directly from air and clothing

In this preliminary study, we have investigated whether dermal uptake of nicotine directly from air or indirectly from clothing can be a meaningful exposure pathway. Two participants wearing only shorts and a third participant wearing clean cotton clothes were exposed to environmental tobacco smoke (ETS), generated by mechanically "smoking" cigarettes, for three hours in a chamber while breathing clean air from head-enveloping hoods. The average nicotine concentration (420 μg/m3 ) was comparable to the highest levels reported for smoking sections of pubs. Urine samples were collected immediately before exposure and 60 hour post-exposure for bare-skinned participants. For the clothed participant, post-exposure urine samples were collected for 24 hour. This participant then entered the chamber for another three-hour exposure wearing a hood and clothes, including a shirt that had been exposed for five days to elevated nicotine levels. The urine samples were analyzed for nicotine and two metabolites-cotinine and 3OH-cotinine. Peak urinary cotinine and 3OH-cotinine concentrations for the bare-skinned participants were comparable to levels measured among non-smokers in hospitality environments before smoking bans. The amount of dermally absorbed nicotine for each bare-skinned participant was conservatively estimated at 570 μg, but may have been larger. For the participant wearing clean clothes, uptake was ~20 μg, and while wearing a shirt previously exposed to nicotine, uptake was ~80 μg. This study demonstrates meaningful dermal uptake of nicotine directly from air or from nicotine-exposed clothes. The findings are especially relevant for children in homes with smoking or vaping.
Balancing privacy concerns in the adoption of Location-Based Services: an empirical analysis

Location-Based Services (LBSs) bring unprecedented mobility and personalisation value to nomadic customers and hence have great commercial potential. However, the commercial potential of LBS is obscured by consumer's privacy concerns whereby the LBS provider can misuse confidential personal information and in extreme circumstances jeopardise an individual's social life or finances. Drawing on the privacy calculus theoretical perspective, we study both pull-based and push-based LBS to provide a comprehensive view of LBS adoption. The results reveal that consumer's privacy concerns influence their intention to adopt directly in case of push-based LBS and indirectly through performance expectancy in case of pull-based LBS.
Pre‐diabetes and serum sex steroid hormones among US men

Several studies demonstrate a link between diabetes and sex steroid hormones, but the link with pre‐diabetes remains elusive. In this study, we hypothesize that pre‐diabetes, which is characterised by having impaired fasting glucose and/or impaired glucose tolerance and/or impaired HbA1C, may influence circulating sex steroid hormone concentrations in men. Thus, we investigated whether serum sex steroid hormone concentrations differ between men with and without pre‐diabetes. We analyzed data for 1139 men who were aged 20+ years when they participated in the Third National Health and Nutrition Examination Survey. We calculated adjusted geometric mean serum concentrations of total and estimated free testosterone, androstanediol glucuronide, total and estimated free estradiol, and sex hormone‐binding globulin (SHBG) in men with and without pre‐diabetes. Logistic regression was used to calculate adjusted odds ratios (OR) of lower concentrations of androgens and SHBG, and higher concentrations of estradiol by prediabetes status. Adjusting for age and race/ethnicity, total testosterone concentration was lower among men with (geometric mean: 4.68 ng/mL) than without (5.36 ng/mL, p = 0.01) pre‐diabetes. SHBG concentration was also lower in men with (31.67 nmol/L) than without (36.16 nmol/L; p = 0.01) pre‐diabetes. Concentrations of the other hormones did not differ between men with and without pre‐diabetes. After adjusting for demographic and lifestyle factors, pre‐diabetic men had a higher odds of lower testosterone (OR: 2.58; 95% CI: 1.54–4.29), higher free estradiol level (OR: 1.59; 95% CI: 1.14–2.22), and lower SHBG level (OR: 2.27; 95% CI: 1.32–3.92) compared to men without pre‐diabetes. These associations were attenuated after adjusting for adiposity (testosterone OR: 1.76; 95% CI 0.95–3.27, free estradiol OR: 1.29, 95% CI: 0.88–1.88, SHBG OR: 1.71; 95% CI 0.88–3.30). Our findings suggest that men with pre‐diabetes have lower circulating total testosterone and SHBG and higher free estradiol levels.
Neurosurgical management of multiple intracranial Nocardia and Enterococcus abscesses in an immunocompetent patient

Abstract Nocardia farcinica and Enterococcus faecium are both rare causes of cerebral abscess. The former is associated with high morbidity and mortality. We describe a neurosurgical approach to the management of multiple intracranial abscesses of dual microbial pathology in an immunocompetent patient to achieve a good outcome.
Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients　- Meta-Analysis.

BACKGROUND Atrial fibrillation (AF) is the most common arrhythmia in the ageing population in East Asia. Silent cerebral infarction (SCI) is defined as cerebral infarction in the absence of corresponding clinical symptoms, and is a highly prevalent and morbid condition in AF. SCI is increasingly being recognized as a risk factor for future stroke, which can lead to cognitive decline or dementia. The latter is an increasingly common health problem in East Asia.Methods and Results:We conducted a meta-analysis to compare the association of AF and SCI between East Asian and non-Asian patients. AF was associated with SCI in patients with no symptomatic stroke history (relative risk [RR], 2.24; 95% CI: 1.26-3.99, I2=83%; P=0.006) although the prevalence varied widely between studies (P for heterogeneity<0.001). In non-Asian patients, the prevalence of SCI in AF is higher than that in controls (RR, 1.85; 95% CI: 1.65-2.08, I2=17%; P<0.001). There was no significant racial difference between Asian and non-Asian studies (P=0.53). CONCLUSIONS In East Asia, AF was significantly associated with SCI and no racial difference was seen between East Asian and non-Asian patients. The present findings offer clinicians new insights into the association between AF and SCI.
Stochastic Hyperparameter Optimization through Hypernetworks

Machine learning models are usually tuned by nesting optimization of model weights inside the optimization of hyperparameters. We give a method to collapse this nested optimization into joint stochastic optimization of both weights and hyperparameters. Our method trains a neural network to output approximately optimal weights as a function of hyperparameters. We show that our method converges to locally optimal weights and hyperparameters for sufficiently large hypernets. We compare this method to standard hyperparameter optimization strategies and demonstrate its effectiveness for tuning thousands of hyperparameters.
The validity of new memory complaints in the elderly.

OBJECTIVE To determine the validity of new subjective memory complaints (MCs) from individuals who previously, when without dementia, denied having MCs. DESIGN Prospective cohort. SETTING Longitudinal, community-based study of aging and dementia. PATIENTS One hundred thirty-three community-dwelling elderly individuals who were part of a registry for the study of conditions related to aging in North Manhattan, NY. Patients were selected if they were initially without dementia and had completed at least 2 successive annual clinical and neuropsychological evaluations and provided their own medical history. MAIN OUTCOME MEASURES Performance on memory tests--the Buschke Selective Reminding Test and a visual memory task--and global performance on a neuropsychological test battery and clinical evaluation, by which questionable dementia or dementia was diagnosed according to a well-defined paradigm. RESULTS Fifty-three subjects with MCs at the initial evaluation performed no worse on the memory test than the 80 subjects who denied MCs initially. There was a weak association between MCs and the diagnosis of questionable dementia at baseline (P = .04), but this was nonsignificant after adjusting for age and education. At 1-year follow-up, 21 of the 80 without baseline MCs now reported MCs. At the follow-up evaluation, these 21 subjects performed significantly worse on the memory tests, were 5 times more likely to have significant cognitive impairment, and had shown significantly greater decline over the preceding year on several of the cognitive measures than the 59 who continued to deny MCs. CONCLUSION New MCs from individuals, who when without dementia recently denied MCs, may suggest the presence of significant impairment of memory or cognition.
Use of acetazolamide in lithium-induced nephrogenic diabetes insipidus: a case report

Summary Lithium-induced nephrogenic diabetes insipidus (Li-NDI) is a rare and difficult-to-treat condition. A study in mice and two recent papers describe the use of acetazolamide in Li-NDI in 7 patients (a case report and a 6 patient series). We describe the case of a 63-year-old woman with bipolar disorder treated with lithium and no previous history of diabetes insipidus. She was hospitalized due to a bowel obstruction and developed severe dehydration after surgery when she was water deprived. After desmopressin administration and unsuccessful thiazide and amiloride treatment, acetazolamide was administrated to control polyuria and hydroelectrolytic disorders without significant side effects. To our knowledge, this is the third publication on acetazolamide use in Li-NDI patients. Learning points: Treatment of lithium-induced nephrogenic diabetes insipidus might be challenging. Vasopressin, amiloride and thiazide diuretics have been used in lithium-induced nephrogenic diabetes insipidus treatment. Acetazolamide might be an option to treat lithium-induced nephrogenic diabetes insipidus patients who fail to respond to standard treatment. The use of acetazolamide in lithium-induced nephrogenic diabetes insipidus must be monitored, including its effects on glomerular filtration rate.
Achilles and patellar tendinopathy display opposite changes in elastic properties: A shear wave elastography study

To compare tendon elastic and structural properties of healthy individuals with those with Achilles or patellar tendinopathy. Sixty‐seven participants (22 Achilles tendinopathy, 17 patellar tendinopathy, and 28 healthy controls) were recruited between March 2015 and March 2016. Shear wave velocity (SWV), an index of tissue elastic modulus, and tendon thickness were measured bilaterally at mid‐tendon and insertional regions of Achilles and patellar tendons by an examiner blinded to group. Analysis of covariance, adjusted for age, body mass index, and sex was used to compare differences in tendon thickness and SWV between the two tendinopathy groups (relative to controls) and regions. Tendon thickness was included as a covariate for analysis of SWV. Compared to controls, participants with Achilles tendinopathy had lower SWV at the distal insertion (Mean difference MD; 95% CI: −1.56; −2.49 to −0.62 m/s; P < .001) and greater thickness at the mid‐tendon (MD 0.19; 0.05‐0.33 cm; P = .007). Compared to controls, participants with patellar tendinopathy had higher SWV at both regions (MD 1.25; 0.40‐2.10 m/s; P = .005) and greater thickness proximally (MD 0.17; 0.06‐0.29 cm; P = .003). Compared to controls, participants with Achilles and patellar tendinopathy displayed lower Achilles tendon elastic modulus and higher patellar tendon elastic modulus, respectively. More research is needed to explore whether maturation, aging, or chronic load underlie these findings and whether current management programs for Achilles and patellar tendinopathy need to be tailored to the tendon.
In Search of a Gold Standard Patient-Reported Outcome Measure for Use in Chemotherapy- Induced Peripheral Neuropathy Clinical Trials

Purpose: To test a reduced version—CIPN15—of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Chemotherapy-Induced Peripheral Neuropathy scale (QLQ-CIPN20) to establish a possible gold-standard patient-reported outcome measure for chemotherapy-induced peripheral neuropathy (CIPN). Methods: Using a prospective, longitudinal, case–control design, patients (n = 121) receiving neurotoxic chemotherapy completed the CIPN15 at baseline and 12 weeks and underwent objective neurological assessment using the 5-item Total Neuropathy Score-Clinical (TNSc). Healthy controls (n = 30) completed the CIPN15 once. Structural validity was evaluated using factor analysis. Because a stable factor structure was not found, a sum score was used to evaluate measures of the CIPN15’s psychometric properties—reliability, validity, sensitivity, and responsiveness—as follows: internal consistency via Cronbach’s α and item–item correlations; test–retest reliability via correlation between 2 CIPN15 scores from each patient; concurrent validity via correlation between CIPN15 and 5-item TNSc scores; contrasting group validity via comparison of CIPN15 scores from patients and healthy controls; sensitivity via descriptive statistics (means, standard deviation, ranges); and responsiveness via Cohen’s d effect size. Results: Most patients received single agent oxaliplatin (33.7%), paclitaxel (21.2%), or more than 1 neurotoxic drug concurrently (29.8%). Factor analysis revealed no stable factor structure. Cronbach’s α for the CIPN15 sum score was 0.91 (confidence interval [CI] = 0.89-0.93). Test–retest reliability was demonstrated based on strong correlations between the 2 scores obtained at the 12-week time point (r = 0.86; CI = 0.80-0.90). The CIPN15 and 5-item TNSc items reflecting symptoms (not signs) were moderately correlated (r range 0.57-0.72): concurrent validity. Statistically significant differences were found between patient and healthy control CIPN15 mean scores (P < .0001): contrasting group validity. All items encompassed the full score range but the CIPN15 linearly converted sum score did not: sensitivity. The CIPN15 was responsive based on a Cohen’s d of 0.52 (CI = 0.25-0.79). Conclusion: The sum-scored CIPN15 is reliable, valid, sensitive, and responsive when used to assess taxane- and platinum-induced CIPN.
Differential short-term memorisation for vocal and instrumental rhythms

This study explores differential processing of vocal and instrumental rhythms in short-term memory with three decision (same/different judgments) and one reproduction experiment. In the first experiment, memory performance declined for delayed versus immediate recall, with accuracy for the two rhythms being affected differently: Musicians performed better than non-musicians on clapstick but not on vocal rhythms, and musicians were better on vocal rhythms in the same than in the different condition. Results for the second experiment showed that concurrent sub-vocal articulation and finger-tapping differentially affected the two rhythms and same/different decisions, but produced no evidence for articulatory loop involvement in delayed decision tasks. In a third experiment, which tested rhythm reproduction, concurrent sub-vocal articulation decreased memory performance, with a stronger deleterious effect on the reproduction of vocal than of clapstick rhythms. This suggests that the articulatory loop may only be involved in delayed reproduction not in decision tasks. The fourth experiment tested whether differences between filled and empty rhythms (continuous vs. discontinuous sounds) can explain the different memorisation of vocal and clapstick rhythms. Though significant differences were found for empty and filled instrumental rhythms, the differences between vocal and clapstick can only be explained by considering additional voice specific features.
Effectiveness of a Psychoeducative Intervention in a Summer Camp for Children With Type 1 Diabetes Mellitus

Purpose The purpose of this study was to evaluate the effectiveness of a psychoeducative intervention implemented in a summer camp for children with type 1 diabetes. Methods A prospective cohort study was conducted comparing 2 groups of children with type 1 diabetes. The intervention group (n = 34) received interventions that addressed knowledge, behaviors, skills, and psychological factors during a summer camp. The control group (n = 23) received the usual education and care. Evaluated measurements were glycosylated hemoglobin (A1C), diabetes knowledge, anxiety, psychological adaptation, and use of health care services. Results No significant changes in A1C annual average, body mass index (BMI), diabetes knowledge, anxiety, medical visits, or hospital admissions were observed after the intervention in comparison with before intervention. Only the adaptation to the school environment improved significantly. The control group significantly increased BMI and A1C. Conclusions No relevant variations in diabetes knowledge, anxiety, psychological adaptation, or use of health care services were found after the psychoeducative intervention implemented in the summer camp. Future studies with random allocation of subjects are necessary to confirm the intervention’s effectiveness.