Miracle-dz/UniFAR-FTUs huggingface dataset:
Crystal structure of methyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate

The title compound, C12H11NO3, is essentially planar, with the mean plane of the acetate side chain [–C—C(=O)—O—C] being inclined to the mean plane of the indole ring system by 12.49 (7)°. The five- and six-membered rings of the indole group are almost coplanar, making a dihedral angle of 1.76 (8)°. The conformation about the C=C bond is E and there is an intramolecular C—H⋯O hydrogen bond present. In the crystal, molecules are linked by pairs of C—H⋯O hydrogen bonds forming inversion dimers, with an R 2 2(16) ring motif. The dimers are linked by a second pair of C—H⋯O hydrogen bonds, enclosing R 2 2(16) ring motifs, forming ribbons lying parallel to (-114). The ribbons are linked via C—H⋯π interactions, forming a three-dimensional structure.
A herbivore that manipulates plant defence

Phytopathogens and herbivores induce plant defences. Whereas there is evidence that some pathogens suppress these defences by interfering with signalling pathways involved in the defence, such evidence is scarce for herbivores. We found that the invasive spider mite Tetranychus evansi suppresses the induction of the salicylic acid and jasmonic acid signalling routes involved in induced plant defences in tomato. This was reflected in the levels of inducible defence compounds, such as proteinase inhibitors, which in mite-infested plants were reduced to even lower levels than the constitutive levels in herbivore-free plants. Additionally, the spider mite suppressed the release of inducible volatiles, which are implicated in plant defence. Consequently, the mites performed much better on previously attacked plants than on non-attacked plants. These findings provide a new perspective on plant–herbivore interactions, plant protection and plant resistance to invasive species.
Aberrant LncRNA Expression Profile in a Contusion Spinal Cord Injury Mouse Model

Long noncoding RNAs (LncRNAs) play a crucial role in cell growth, development, and various diseases related to the central nervous system. However, LncRNA differential expression profiles in spinal cord injury are yet to be reported. In this study, we profiled the expression pattern of LncRNAs using a microarray method in a contusion spinal cord injury (SCI) mouse model. Compared with a spinal cord without injury, few changes in LncRNA expression levels were noted 1 day after injury. The differential changes in LncRNA expression peaked 1 week after SCI and subsequently declined until 3 weeks after injury. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the reliability of the microarray, demonstrating that the results were reliable. Gene ontology (GO) analysis indicated that differentially expressed mRNAs were involved in transport, cell adhesion, ion transport, and metabolic processes, among others. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that the neuroactive ligand-receptor interaction, the PI3K-Akt signaling pathway, and focal adhesions were potentially implicated in SCI pathology. We constructed a dynamic LncRNA-mRNA network containing 264 LncRNAs and 949 mRNAs to elucidate the interactions between the LncRNAs and mRNAs. Overall, the results from this study indicate for the first time that LncRNAs are differentially expressed in a contusion SCI mouse model.
To Measure or not to Measure UX: An Interview Study

The fundamental problem of defining what UX is (or is not) has a significant influence on another challenging question: to measure or not to measure UX constructs. The answer of most, if not all, UX researchers and practitioners, would probably be “It depends! ” As we were motivated to find out “depending on what”, we conducted semi-structured interviews with eleven UX professionals where a set of questions in relation to UX measurement were explored. Participants expressed scepticism as well as ambivalence towards UX measures and shared anecdotes related to such measures in different contexts. To improve the interplay between UX evaluation and system development, a clear definition of UX, combining various data types, and robust education in UX concepts are deemed essential. Author Keywords
Entering a New Era of Body Indices: The Feasibility of a Body Shape Index and Body Roundness Index to Identify Cardiovascular Health Status

Background The Body Mass Index (BMI) and Waist Circumference (WC) are well-used anthropometric predictors for cardiovascular diseases (CVD), but their validity is regularly questioned. Recently, A Body Shape Index (ABSI) and Body Roundness Index (BRI) were introduced as alternative anthropometric indices that may better reflect health status. Objective This study assessed the capacity of ABSI and BRI in identifying cardiovascular diseases and cardiovascular disease risk factors and determined whether they are superior to BMI and WC. Design and Methods 4627 Participants (54±12 years) of the Nijmegen Exercise Study completed an online questionnaire concerning CVD health status (defined as history of CVD or CVD risk factors) and anthropometric characteristics. Quintiles of ABSI, BRI, BMI, and WC were used regarding CVD prevalence. Odds ratios (OR), adjusted for age, sex, and smoking, were calculated per anthropometric index. Results 1332 participants (27.7%) reported presence of CVD or CVD risk factors. The prevalence of CVD increased across quintiles for BMI, ABSI, BRI, and WC. Comparing the lowest with the highest quintile, adjusted OR (95% CI) for CVD were significantly different for BRI 3.2 (1.4–7.2), BMI 2.4 (1.9–3.1), and WC 3.0 (1.6–5.6). The adjusted OR (95% CI) for CVD risk factors was for BRI 2.5 (2.0–3.3), BMI 3.3 (1.6–6.8), and WC 2.0 (1.6–2.5). No association was observed for ABSI in both groups. Conclusions BRI, BMI, and WC are able to determine CVD presence, while ABSI is not capable. Nevertheless, the capacity of BRI as a novel body index to identify CVD was not superior compared to established anthropometric indices like BMI and WC.
The Differential Role of Extracellular Signal-Regulated Kinases and p38 Mitogen-Activated Protein Kinase in Eosinophil Functions1

The activation of eosinophils by cytokines is a major event in the pathogenesis of allergic diseases. We have investigated the activation of mitogen-activated protein (MAP) kinases and their functional relevance in eosinophil differentiation, survival, degranulation, and cytokine production. IL-5 induced phosphorylation and activation of extracellular signal-regulated kinases (ERK) and p38 MAP kinases in eosinophils. PD98059, a MAP/ERK kinase inhibitor, blocked phosphorylation of ERK1/2 in a dose-dependent manner. SB202190, a p38 inhibitor, blocked p38-dependent phosphorylation of activating transcription factor-2. To study the importance of the MAP kinases on eosinophil differentiation, we cultured mouse bone marrow cells with IL-3 and IL-5 in the presence of the inhibitors. SB202190 dramatically inhibited eosinophil differentiation by 71%. PD98059 was less potent and reduced eosinophil differentiation by 28%. Both inhibitors marginally inhibited eosinophil survival only at the highest doses. Prolonged incubation of eosinophils with IL-5 induced significant eosinophil-derived neurotoxin release. Both PD98059 and SB202190 nearly completely inhibited (87% and 100% inhibition, respectively) IL-5-stimulated eosinophil-derived neurotoxin release in a dose-dependent manner. Next, we examined the effect of the MAP kinase inhibitors on eosinophil production of the cytokine macrophage-inflammatory protein (MIP)-1α. PD98059 blocked C5a- but not ionomycin-induced MIP-1α production (59% inhibition at 50 μM concentration). In contrast, SB202190 nearly completely inhibited (99%) C5a-induced MIP-1α production. Further, it blocked ionomycin-stimulated production by 66%. Our results suggest that both p38 and ERK1/2 MAP kinases play an important role in eosinophil differentiation, cytokine production, and degranulation. The p38 MAP kinase plays a greater role than ERK1/2 in eosinophil differentiation and cytokine production.
Designing High Performance Enterprise Wi-Fi Networks

Use of mobile computing devices such as laptops, PDAs, and Wi-Fi enabled phones is increasing in the workplace. As the usage of corporate 802.11 wireless networks (WLANs) grows, network performance is becoming a significant concern. We have built DenseAP, a novel system for improving the performance of enterprise WLANs using a dense deployment of access points (APs). In sharp contrast with wired networks, one cannot increase the capacity of a WLAN by simply deploying more equipment (APs). To increase capacity, the APs must be assigned appropriate channels and the clients must make intelligent decisions about which AP to associate with. Furthermore, the decisions about channel assignment, and associations must be based on a global view of the entire WLAN, rather than the local viewpoint of an individual client or AP. Given the diversity of Wi-Fi devices in use today, another constraint on the design of DenseAP is that it must not require any modification to Wi-Fi clients. In this paper, we show how the DenseAP system addresses these challenges, and provides significant improvements in performance over existing WLANs.
Statistical reform in information retrieval?

IR revolves around evaluation. Therefore, IR researchers should employ sound evaluation practices. Nowadays many of us know that statistical significance testing is not enough, but not all of us know exactly what to do about it. This paper provides suggestions on how to report effect sizes and confidence intervals along with p-values, in the context of comparing IR systems using test collections. Hopefully, these practices will make IR papers more informative, and help researchers form more reliable conclusions that "add up. " Finally, I pose a specific question for the IR community: should IR journal editors and SIGIR PC chairs require (rather than encourage) reporting of effect sizes and confidence intervals.
Interpolation for data structures

Interpolation based automatic abstraction is a powerful and robust technique for the automated analysis of hardware and software systems. Its use has however been limited to control-dominated applications because of a lack of algorithms for computing interpolants for data structures used in software programs. We present efficient procedures to construct interpolants for the theories of arrays, sets, and multisets using the reduction approach for obtaining decision procedures for complex data structures. The approach taken is that of reducing the theories of such data structures to the theories of equality and linear arithmetic for which efficient interpolating decision procedures exist. This enables interpolation based techniques to be applied to proving properties of programs that manipulate these data structures.
Using a Partial Sum Method and GPS Tracking Data to Identify Area Restricted Search by Artisanal Fishers at Moored Fish Aggregating Devices in the Commonwealth of Dominica

Foragers must often travel from a central place to exploit aggregations of prey. These patches can be identified behaviorally when a forager shifts from travel to area restricted search, identified by a decrease in speed and an increase in sinuosity of movement. Faster, more directed movement is associated with travel. Differentiating foraging behavior at patches from travel to patches is important for a variety of research questions and has now been made easier by the advent of small, GPS devices that can track forager movement with high resolution. In the summer and fall of 2012, movement data were collected from GPS devices placed on foraging trips originating in the artisanal fishing village of Desa Ikan (pseudonym), on the east coast of the Caribbean island nation of the Commonwealth Dominica. Moored FADs are human-made structures anchored to the ocean floor with fish attraction material on or near the surface designed to effectively create a resource patch. The ultimate goal of the research is to understand how property rights are emerging after the introduction of fish aggregating device (FAD) technology at the site in 1999. This paper reports on research to identify area-restricted search foraging behavior at FAD patches. For 22 foraging trips simultaneous behavioral observations were made to ground-truth the GPS movement data. Using a cumulative sum method, area restricted search was identified as negative deviations from the mean travel speed and the method was able to correctly identify FAD patches in every case.
Aesthetic Evaluation of the Nasolabial Region in Children with Unilateral Cleft Lip and Palate Comparing Expert versus Nonexperience Health Professionals

Esthetic evaluation of cleft lip and palate rehabilitation outcomes may assist in the determination of new surgical interventions and aid in reevaluation of treatment protocols. Our objective was to compare esthetics assessments of the nasolabial region in children with a unilateral cleft lip and palate between healthcare professionals who were experienced in the treatment of cleft lip and palate and those who were inexperienced. The study group included 55 patients between 6 and 12 years of age who had already undergone primary reconstructive surgery for unilateral cleft lip. Standardized digital photographs were obtained, and the esthetic features of the nose, lip, and nasolabial region were evaluated. We used only cropped photographic images in the assessments of healthcare professionals with and without experience in cleft lip and palate. Interrater analysis revealed highly reliable assessments made by both the experienced and inexperienced professionals. There was no statistically significant difference in the esthetic attractiveness of the lip and nose between the experienced and inexperienced professionals. Compared with the inexperienced professionals, the experienced professional evaluators showed higher satisfaction with the esthetic appearance of the nasolabial region; however, no difference was observed in the analysis of the lip or nose alone.
Depth Artifacts Caused by Spatial Interlacing in Stereoscopic 3D Displays

Most spatially interlacing stereoscopic 3D displays display odd and even rows of an image to either the left or the right eye of the viewer. The visual system then fuses the interlaced image into a single percept. This row-based interlacing creates a small vertical disparity between the images; however, interlacing may also induce horizontal disparities, thus generating depth artifacts. Whether people perceive the depth artifacts and, if so, what is the magnitude of the artifacts are unknown. In this study, we hypothesized and tested if people perceive interlaced edges on different depth levels. We tested oblique edge orientations ranging from 2 degrees to 32 degrees and pixel sizes ranging from 16 to 79 arcsec of visual angle in a depth probe experiment. Five participants viewed the visual stimuli through a stereoscope under three viewing conditions: noninterlaced, interlaced, and row averaged (i.e., where even and odd rows are averaged). Our results indicated that people perceive depth artifacts when viewing interlaced stereoscopic images and that these depth artifacts increase with pixel size and decrease with edge orientation angle. A pixel size of 32 arcsec of visual angle still evoked depth percepts, whereas 16 arcsec did not. Row-averaging images effectively eliminated these depth artifacts. These findings have implications for display design, content production, image quality studies, and stereoscopic games and software.
Activation of Lymphocytes Induced by Bronchial Epithelial Cells with Prolonged RSV Infection

Respiratory syncytial virus (RSV) preferentially infects airway epithelial cells,which might be responsible for susceptibility to asthma; however, the underlying mechanism is not clear. This study determined the activation of lymphocytes and drift of helper T (Th) subsets induced by RSV-infected human bronchial epithelial cells (HBECs) in vitro. HBECs had prolonged infection with RSV, and lymphocytes isolated from human peripheral blood were co-cultured with RSV-infected HBECs. Four groups were established, as follows: lymphocytes (group L); lymphocytes infected with RSV (group RL); co-culture of lymphocytes with non-infected HBECs (group HL); and co-culture of lymphocytes with infected HBECs (group HRL). After co-culture with HBECs for 24 hours, lymphocytes were collected and the following were determined in the 4 groups: cell cycle status; apoptosis rate; and concentrations of IL-4, IFN-γ, and IL-17 in the supernatants. Cell cycle analysis for lymphocytes showed a significant increase in S phase cells, a decrease in G1 phase cells, and a higher apoptosis rate in group HRL compared with the other three groups. In group HRL, the levels of IL-4, IFN-γ, and IL-17 in supernatants were also higher than the other three groups. For further study, lymphocytes were individually treated with supernatants from non-infected and RSV-infected HBECs for 24 h. We showed that supernatants from RSV-infected HBECs induced the differentiation of Th2 and Th17 subsets, and suppressed the differentiation of Treg subsets. Our results showed that HBECs with prolonged RSV infection can induce lymphocyte proliferation and apoptosis, and enhance the release of cytokines by lymphocytes. Moreover, subset drift might be caused by RSV-infected HBECs.
Enhanced Odor Discrimination and Impaired Olfactory Memory by Spatially Controlled Switch of AMPA Receptors

Genetic perturbations of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In this study, we investigated the role of Ca2+-permeable AMPARs in olfactory behavior. AMPAR modification was obtained by depletion of the GluR-B subunit or expression of unedited GluR-B(Q), both leading to increased Ca2+ permeability of AMPARs. Mice with this functional AMPAR switch, specifically in forebrain, showed enhanced olfactory discrimination and more rapid learning in a go/no-go operant conditioning task. Olfactory memory, however, was dramatically impaired. GluR-B depletion in forebrain was ectopically variable (“mosaic”) among individuals and strongly correlated with decreased olfactory memory in hippocampus and cortex. Accordingly, memory was rescued by transgenic GluR-B expression restricted to piriform cortex and hippocampus, while enhanced odor discrimination was independent of both GluR-B variability and transgenic GluR-B expression. Thus, correlated differences in behavior and levels of GluR-B expression allowed a mechanistic and spatial dissection of olfactory learning, discrimination, and memory capabilities.
Comparison of ropivacaine 0.1% and 0.2% with bupivacaine 0.2% for single‐shot caudal anaesthesia in children

We compared analgesic efficacy and degree of motor block induced by ropivacaine 0.1% (R 0.1) and 0.2% (R 0.2) vs. bupivacaine 0.2% (B 0.2) after caudal anaesthesia in children. Total and free plasma concentrations were measured after caudal injection. Duration of caudal analgesia (median/range) was significantly shorter in group R 0.1 (1.7 h/0.2–6 h) than in group R 0.2 (4.5 h/1.7–6 h) or group B 0.2 (4 h/1–6 h) (P < 0.05). Motor block in the first 2 h postoperatively was significantly less for both ropivacaine groups compared with bupivacaine (P < 0.05). Peak plasma concentrations after ropivacaine 0.2% were higher and protein binding lower than after bupivacaine 0.2% (P < 0.05). We conclude that caudal analgesia with ropivacaine 0.1% is less effective and of shorter duration than that of ropivacaine 0.2%, whereas ropivacaine 0.2% provides pain relief similar to bupivacaine 0.2%. Motor block in the early postoperative period is less with ropivacaine than with bupivacaine.
Bacterial Colony from Two-Dimensional Division to Three-Dimensional Development

On agar surface, bacterial daughter cells form a 4-cell array after the first two rounds of division, and this phenomenon has been previously attributed to a balancing of interactions among the daughter bacteria and the underneath agar. We studied further the organization and development of colony after additional generations. By confocal laser scanning microscopy and real-time imaging, we observed that bacterial cells were able to self-organize and resulted in a near circular micro-colony consisting of monolayer cells. After continuous dividing, bacteria transited from two-dimensional expansion into three-dimensional growth and formed two to multi-layers in the center but retained a monolayer in the outer ring of the circular colony. The transverse width of this outer ring appeared to be approximately constant once the micro-colony reached a certain age. This observation supports the notion that balanced interplays of the forces involved lead to a gross morphology as the bacteria divide into offspring on agar surface. In this case, the result is due to a balance between the expansion force of the dividing bacteria, the non-covalent force among bacterial offspring and that between bacteria and substratum.
Effects of inhaled cigarette smoke on the myo-articular system of female rats with collagen-induced arthritis

Rheumatoid arthritis (RA) imposes substantial costs on society, due to both the costs of treatment and the increase in work-related deficiencies; it also accelerates mortality.1 Studies have shown that cigarettes are a factor in the development of RA and also in the worsening of an already present condition, potentially modifying the gravity of RA.2,3 However, the importance of tobacco on the overall effects of RA remains unknown.2 It was shown that the prevalence of RA in Caucasian women with a genetic predisposition and who smoked was greater than in those with a genetic predisposition but did not smoke.4 In addition, RA, either isolated from or associated with smoking, leads to a compromised musculoskeletal system. If this condition is not controlled and is combined with a sedentary lifestyle, a compromised musculoskeletal system can cause a series of complications that culminate in a decrease in functionality and quality of life that is associated with increased rates of morbidity and mortality relative to the healthy population.5 Thus, the objective of this study was to analyze the effects of cigarette smoke on the myo-articular system of rats with induced arthritis.
An overview of turbo codes and their applications

More than ten years after their introduction, turbo Codes are now a mature technology that has been rapidly adopted for application in many commercial transmissions systems. This paper provides an overview of the basic concepts employed in convolutional and block turbo codes, and review the major evolutions in the field with an emphasis on practical issues such as implementation complexity and high-rate circuit architectures. We address the use of these technologies in existing standards and also discuss future potential applications for this error-control coding technology