Miracle-dz/UniFAR-FTUs huggingface dataset:
Contemporary Identities of Creativity and Creative Work

Creative workers have been celebrated internationally for their flexibility in new labour markets centred on culture, creativity and, most recently, innovation. This book draws on research with novice and established workers in a range of specialisations to explore the new meanings, aspirations and difficulties associated with a contemporary creative identification. The book investigates the difficulties and attraction of creative work as a personalised, affect-laden project, perpetually open and oriented to possibility, uncertain in its trajectory or rewards. Employing a cross- disciplinary methodology and analytic approach the book investigates the new cultural meanings in play around creative working and a creative career. It shows how classic ideals of Design and the creative arts, re-interpreted and promoted within contemporary art schools, validate the lived experience of precarious working in the global sectors of the creative and cultural industries, yet also contribute to its conflicts. 'Contemporary identities of creativity and creative work' presents a distinctive study and original findings which make it essential reading for social scientists, including social psychologists, with an interest in cultural and media studies, creativity, identity and identification and contemporary work.
Characterizing polynomial Ramsey quantifiers

Abstract Ramsey quantifiers are a natural object of study not only for logic and computer science but also for the formal semantics of natural language. Restricting attention to finite models leads to the natural question whether all Ramsey quantifiers are either polynomial-time computable or NP-hard, and whether we can give a natural characterization of the polynomial-time computable quantifiers. In this paper, we first show that there exist intermediate Ramsey quantifiers and then we prove a dichotomy result for a large and natural class of Ramsey quantifiers, based on a reasonable and widely believed complexity assumption. We show that the polynomial-time computable quantifiers in this class are exactly the constant-log-bounded Ramsey quantifiers.
The effects of carbamazepine and valproic acid on the erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children.

Some epileptic drugs may change antioxidant enzyme activities in humans and experimental animals. Recent studies suggest that membrane lipid peroxidation may be causally involved in some forms of epilepsy, and the differences are reported in free radical scavenging enzyme levels. GSHpX, SOD, GSH are important parameters of antioxidant defence mechanisms. This study was undertaken to evaluate the effects of valproic acid and carbamazepine (CBZ) therapy on erythrocyte glutathione (GSH), glutathione peroxidase (GSHpX), superoxide dismutase (SOD) and lipid peroxidation. During the treatment with VPA or CBZ, the erythrocyte GSHpX and GSH levels of epileptic children were significantly changed as compared to those of health control subjects. The mean levels of serum lipid peroxidation and erythrocyte superoxide dismutase were not statistically different from controls. The methods used for investigation of glutathione peroxidase, superoxide dismutase, glutathione and serum lipid peroxidation were all based on spectrophotometric measurement.
Performance Comparisons of a Content-Addressable Storage Network System and Other Typical IP-SAN Based Storage Systems

Content-Addressable Storage (CAS) is a model of storage facility used for keeping immutable digital content records with peculiar advantages. This paper presents a prototype of CAS Area Network system compliant to the OSD (Object-based Storage Device) T-10 standard. The experimental results demonstrate the performance of the model is comparable to and better than that of regular storage systems. The directions about bottleneck and optimization of the real system accord with the conclusions deduced by our performance evaluation model.
Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II‐defined cohort of patients with progressive multiple sclerosis: results of a 24‐month double‐blind placebo‐controlled clinical trial and 5 years of follow‐up treatment

MBP8298 is a synthetic peptide with a sequence corresponding to amino acid residues 82–98 of human myelin basic protein (DENPVVHFFKNIVTPRT). It represents the immunodominant target for both B cells and T cells in multiple sclerosis (MS) patients with HLA haplotype DR2. Its administration in accordance with the principle of high dose tolerance results in long‐term suppression of anti‐myelin basic protein (MBP) autoantibody levels in the cerebrospinal fluid (CSF) of a large fraction of progressive MS patients. MBP8298 was evaluated in a 24‐month placebo‐controlled double‐blinded Phase II clinical trial in 32 patients with progressive MS. The objective was to assess the clinical efficacy of 500 mg of MBP8298 administered intravenously every 6 months, as measured by changes in Expanded Disability Status Scale (EDSS) scores. Contingency analysis for all patients at 24 months showed no significant difference between MBP8298 and placebo‐treatments (n = 32, P = 0.29). Contingency analysis in an HLA Class II defined subgroup showed a statistically significant benefit of MBP8298 treatment compared with placebo in patients with HLA haplotypes DR2 and/or DR4 (n = 20, P = 0.01). Long‐term follow‐up treatment and assessment of patients in this responder group showed a median time to progression of 78 months for MBP8298 treated patients compared with 18 months for placebo‐treatment (Kaplan–Meier analysis, P = 0.004; relative rate of progression = 0.23). Anti‐MBP autoantibody levels in the CSF of most MBP8298 treated patients were suppressed, but antibody suppression was not predictive of clinical benefit. Anti‐MBP autoantibodies that reappeared in the CSF of one patient at 36 months, whilst under treatment with MBP8298, were not reactive with the MBP8298 peptide in vitro. The identification of a responder subgroup (62.5% of the patients in this study) enables a more efficient design of a large confirmatory clinical trial of MBP8298. The probability that patients with other less common HLA‐DR haplotypes will respond to this treatment should not be ignored.
Handbook of Personality: Theory and Research

Part 1. Introduction. N.B. Barenbaum, D.G. Winter, History of Modern Personality Theory and Research. Part 2. Theoretical Perspectives. D.M. Buss, Human Nature and Individual Differences: Evolution of Human Personality. D. Westen, G.O. Gabbard, K.M. Ortigo, Psychoanalytic Approaches to Personality. O.P. John, L.P. Naumann, C.J. Soto, Paradigm Shift to the Integrative Big Five Trait Taxonomy: History, Measurement, and Conceptual Issues. R.R. McCrae, P.T. Costa, Jr., The Five-Factor Theory of Personality. E.T. Higgins, A.A. Scholer, When Is Personality Revealed? A Motivated Cognition Approach. W. Mischel, Y. Shoda, Toward a Unifying Theory of Personality: Integrating Dispositions and Processing Dynamics within the Cognitive-Affective Processing System. D.P. McAdams, Personal Narratives and the Life Story. Part 3. Biological Bases. L.A. Clark, D. Watson, Temperament: An Organizing Paradigm for Trait Psychology. R.F. Krueger, W. Johnson, Behavioral Genetics and Personality: A New Look at the Integration of Nature and Nurture. T. Canli, Toward a "Molecular Psychology" of Personality. T.A. R. Weinstein, J.P. Capitanio, S.D. Gosling, Personality in Animals. Part 4. Developmental Approaches. E.M. Pomerantz, R.A. Thompson, Parents' Role in Children's Personality Development: The Psychological Resource Principle. B.W. Roberts, D. Wood, A. Caspi, The Development of Personality Traits in Adulthood. C.D. Ryff, Challenges and Opportunities at the Interface of Aging, Personality, and Well-Being. Part 5. Self and Social Processes. R.W. Robins, J.L. Tracy, K.H. Trzesniewski, Naturalizing the Self. W.B. Swann, Jr., J.K. Bosson, Identity Negotiation: A Theory of Self and Social Interaction. M.T. Gailliot, N.L. Mead, R.F. Baumeister, Self-Regulation. D.L. Paulhus, P.D. Trapnell, Self-Presentation of Personality: An Agency-Communion Framework. R.C. Fraley, P.R. Shaver, Attachment Theory and Its Place in Contemporary Personality Theory and Research. V. Benet-Martinez, S. Oishi, Culture and Personality. D.C. Funder, Personality, Situations, and Person-Situation Interactions. Part 6. Cognitive and Motivational Processes. J.F. Kihlstrom, The Psychological Unconscious. O.C. Schultheiss, Implicit Motives. R.A. Emmons, J.L. Barrett, S.A. Schnitker, Personality and the Capacity for Religious and Spiritual Experience. R.M. Ryan, E.L. Deci, Self-Determination Theory and the Role of Basic Psychological Needs in Personality and the Organization of Behavior. D.K. Simonton, Creativity and Genius. Part 7. Emotion, Adjustment, and Health. J.J. Gross, Emotion and Emotion Regulation: Personality Processes and Individual Differences. C.S. Carver, M.F. Scheier, D. Fulford, Self-regulatory Processes, Stress, and Coping. T.A. Widiger, G.T. Smith, Personality and Psychopathology. S.E. Hampson, H.S. Friedman, Personality and Health: A Lifespan Perspective. R.E. Lucas, E. Diener, Personality and Subjective Well-Being.
BIOAVAILABILITY OF LIQUID METHIONINE HYDROXY ANALOGUE-FREE ACID RELATIVE TO DL-METHIONINE IN BROILERS

ZELENKA JIŘI, HEGER JAROSLAV, MACHANDER VLASTISLAV, WILTAFSKY MARKUS, LESTAK MARTIN: Bioavailability of liquid methionine hydroxy analogue-free acid relative to DL-methionine in broilers. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013, LXI, No. 5, pp. 1513– 1520 An experiment with broiler chickens was conducted to compare the relative bioavailability of liquid methionine hydroxy analogue free acid (MHA-FA) with that of DL-methionine (DLM) during fattening to 35 days of age. Ross 308 male chicks were allotted to 9 treatments, each consisting of six replicates of 140 birds/pen. Four graded levels (0.04, 0.08, 0.16, and 0.28 %) of MHA-FA or DLM products (weight/ weight comparison) were added to a maize-wheat-soyabean meal basal diet defi cient in sulphur amino acids. The criteria of response were body weight, feed conversion ratio, carcass yield and breast meat yield. Signifi cant responses to graded levels of both methionine sources were observed in all response criteria. Using a multi-exponential model describing the dose-response relationships, the bioavailability estimates of MHA-FA relative to DLM on a weight-to-weight basis were 68, 70, 54 and 59 % for body weight, feed conversion, carcass yield and breast meat yield, respectively. If MHA-FA was compared with DLM on equimolar basis its bioavailability was 77.7, 79.0, 59.3 and 64.6 for body weight, feed conversion, carcass yield and breast meat yield, respectively. The bioavailability of MHA-FA for carcass yield and breast meat yield was signifi cantly (P < 0.05) lower than that of DLM on a weight-to-weight and on equimolar basis. DLM, MHA-FA, chicken, weight gain, feed conversion, carcass yield, breast meat yield
Peroxisomal proteomic approach for protein profiling in blue mussels (Mytilus edulis) exposed to crude oil

Abstract Peroxisomal proteomic protein profiles of exposure to marine pollution have been recently introduced in biomonitoring experiments. However, laboratory experiments to study the independent effect of common pollutants are needed to define a minimal protein expression signature (PES) of exposure to a specific pollutant. The aim of this study was to obtain PESs in blue mussels (Mytilus edulis) exposed to two different crude oil mixtures for future application in biomonitoring areas affected by oil spills. In the study, peroxisome-enriched fractions from digestive gland of M. edulis (L., 1758) were analysed by two-dimensional fluorescence difference electrophoresis (DIGE) and mass spectrometry (MS) after 3 weeks of exposure to crude oil mixtures: crude oil or crude oil spiked with alkylated phenols (AP) and extra polycyclic aromatic hydrocarbons (PAH) in a laboratory flow-through system. A minimal PES composed by 13 protein spots and unique PESs of exposure to the two different mixtures were identified. A total of 22 spots from the two-dimensional maps that had shown a significant increase or decrease in abundance in each of the exposed groups exposed were analysed. The hierarchical clustering analysis succeeded in discriminating the exposed groups from the control groups based on the unique PES. The PESs obtained were consistent with protein patterns obtained in previous field experiments. The results suggest that the protein profiles obtained by peroxisomal proteomics could be used to assess oil exposure in marine pollution assessments.
Long-Term Inhibition of Xanthine Oxidase by Febuxostat Does Not Decrease Blood Pressure in Deoxycorticosterone Acetate (DOCA)-Salt Hypertensive Rats

Xanthine oxidase and its products, uric acid and ROS, have been implicated in the pathogenesis of cardiovascular disease, such as hypertension. We have previously reported that allopurinol inhibition of XO does not alter the progression of deoxycorticosterone acetate (DOCA)-salt hypertension in rats. However other researchers have observed a reduction in blood pressure after allopurinol treatment in the same model. To resolve this controversy, in this study we used the newer and more effective XO inhibitor febuxostat, and hypothesized that a more complete XO blockade might impair hypertension development and its end-organ consequences. We used DOCA-salt hypertensive rats and administered vehicle (salt water) or febuxostat (orally, 5 mg/kg/day in salt water) in a short-term “reversal” experiment (2 weeks of treatment 3 weeks after DOCA-salt beginning) and a long-term “prevention” experiment (treatment throughout 4 weeks of DOCA-salt). We confirmed XO inhibition by febuxostat by measuring circulating and tissue levels of XO metabolites. We found an overall increase in hypoxanthine (XO substrate) and decrease in uric acid (XO product) levels following febuxostat treatment. However, despite a trend for reduced blood pressure in the last week of long-term febuxostat treatment, no statistically significant difference in hemodynamic parameters was observed in either study. Additionally, no change was observed in relative heart and kidney weight. Aortic media/lumen ratio was minimally improved by long-term febuxostat treatment. Additionally, febuxostat incubation in vitro did not modify contraction of aorta or vena cava to norepinephrine, angiotensin II or endothelin-1. We conclude that XO inhibition is insufficient to attenuate hypertension in the rat DOCA-salt model, although beneficial vascular effects are possible.
Using Aspirin to Prevent Colorectal Cancer : An Evidence Based Practice

Correspondence: Haneyah Alnabali, RN. , MSN. Madinah Cardiac Center Saudi Arabia Email: haneyahalnabali@yahoo.com Introduction Colorectal cancer (CRC) is the third most common cancer in the United States, and it is the third leading cause of cancer-related deaths when men and women are considered discretely, while it is the second leading cause when both sexes are combined. Unfortunately, CRC was expected to cause about 50,830 deaths during 2013 in U.S.[1].
A major anti-myoglobin idiotype. Influence of H-2-linked Ir genes on idiotype expression

A rabbit antiidiotypic antiserum raised against an A.SW IgG1K monoclonal anti-sperm whale myoglobin (Mb) antibody, HAL19, and extensively absorbed with normal mouse immunoglobulin and MOPC 21 (IgG1K), was found to detect a common or major anti-Mb idiotype expressed by some but not all anti-Mb monoclonal antibodies, regardless of immunoglobulin G (IgG) subclass, and by 40-50% of the anti-Mb antibodies in immune serum from five high responder strains of mice representing five different Igh allotypes. It did not inhibit antibodies to three unrelated protein antigens. The fraction of antibodies expressing this idiotype, denoted IdHAL19, was regulated by H-2-linked genes that correlated exactly in four independent haplotypes and an F1 with the known Mb immune response (Ir) genes and may be identical to these. Whereas less than 50% of antibodies from high responder mice were inhibitable by anti-IdHAL19, greater than 80% of antibodies from low responder mice, tested at comparable final antibody concentration, were inhibitable. This result was true for both low responder haplotypes, H-2b (B10) and H-2k (B10.BR). The idiotype was found to be present on antibodies that bound to native Mb but not fragments 1-55 or 132-153 of Mb or a denatured form, S-methyl Mb. This specificity for native Mb paralleled that of the monoclonal idiotype HAL19 itself. Therefore, the production of antibodies specific for native in contrast to denatured Mb was studied in H-2-congenic high and low responder strains. Strikingly, low responders produced antibodies that reacted almost exclusively with the native conformation, whereas a larger proportion of antibodies from high responder mice also reacted with the denatured form, S-methyl Mb. Bypassing of the Ir gene defect by immunization with Mb attached to a carrier, F gamma G, resulted in low responder antisera resembling higher responder sera in both idiotype expression and conformational specificity. The simplest explanation of these results is that H-2-linked Ir genes control antibody fine specificity, which is reflected in the idiotypes of the variable regions expressed. We suggest that low responder mice produce a more limited repertoire of antibodies consisting primarily of IdHAL19- positive antibodies specific for the native conformation of Mb. High responder mice produce a greater diversity of antibodies to Mb, so that the IdHAL19-positive, conformation-specific population represents a smaller proportion of the total. Similarly, the use of carrier-specific helper T cells in low responder mice results in a greater diversity of antibodies, which dilutes out the IdHAL19 subset. (ABSTRACT TRUNCATED AT 400 WORDS)
Apparent Amnesia : interidentity memory functioning in dissociative identity disdorder

Dissociative identity disorder (DID) is characterized by the presence of two or more distinct identities or personality states that recurrently take control of the individual s behavior. Between 95 and 100 % of DID patients report experiences of blank spells for periods of time when other identities are in control of their behavior. In this thesis, the fundamental question of whether objective evidence for the reported interidentity amnesia in DID can be found under rigorous experimental conditions was addressed. The thesis provides a systematic exploration of interidentity amnesia in DID for both neutral as well as trauma-related information on a variety of different encoding and retrieval tasks. In order to provide an unequivocal measure of memory performance, much attention was given to the use of tasks on which simulation of amnesia-symptoms is expected to be very difficult. Also, a control group instructed to simulate DID was included. The conclusion that can be drawn is that, the patients results did not indicate amnesia but transfer of information between the identities tested. How can the discrepancy between patient s reports of interidentity amnesia and the lack of objective test results be reconciled? The DID patients experience of amnesia may result from a faulty cognitive evaluation of a recollection after intact memory retrieval. Because patients are convinced of having different identities, they construct an image of their memories being compartmentalized in their separate identities. This distortion may lead them not to use some retrieved memories, that they are convinced belong to other identities. Deciding not to use correctly retrieved information then lies at the basis of their amnesia-like behaviors. These behaviors may thus reflect the patient s appraisal of retrieved memories as ego-dystonic or ego-syntonic rather than a memory encoding and/or retrieval impairment.
Can Breast Self-Examination Continue to Be Touted Justifiably as an Optional Practice?

In 2003, the revised American Cancer Society guidelines recommended that breast self-examination (BSE) be optional. Of 822 women diagnosed with breast cancer in our hospital from 1994 to 2004, sixty four (7.7%) were 40 years of age or younger. Forty four (68.7%) of these young women discovered their breast cancers on BSE, 17 (18%) by mammography, and 3 (4.7%) by clinical breast examination by medical professionals. Of 758 women over 40 years of age diagnosed with breast cancer, 382 (49%) discovered their cancer by mammography, 278 (39%) by BSE, and 98 (14%) by a clinical breast examination. Lymph node metastases in the older women was one-half that in the younger women (21% versus 42%), and a higher percentage of younger women presented with more advanced disease. In response to increasing breast cancer in young women under 41 years of age, encouragement of proper breast self-examination is warranted and should be advocated.
Voltage Dependence of Cardiac Delayed Rectifier Block by Methanesulfonamide Class III Antiarrhythmic Agents

Summary Voltage-clamp experiments were performed on isolated guinea pig ventricular myocytes to examine the voltage dependence of delayed rectifier block by methanesulfonamide channel blockers. Voltage-dependent channel block, in which block decreases as membrane potential is made more positive, could contribute to the phenomenon of reverse use dependence, in which the magnitude of the drug-induced prolongation in action potential duration (APD) is inversely proportional to stimulation rate. To determine whether such a voltage dependence exists, concentration-response curves were generated for dofetilide, E-4031, sematilide, and D,L-sotolal at test potentials ranging from 0 to 60 mV. All agents blocked current in a manner consistent with selective blockade of the rapidly activating component of delayed rectifier current, IKr. The rank order of potency was E-4031 = dofetilide > sematilide > sotalol. Block of tail currents by this class of compounds was more potent after test potentials to +60 mV than after those =≤ 0–10 mV. These data are inconsistent with voltage-dependent channel block being a contributing factor to reverse use-dependence and suggest that other mechanisms must be responsible for this phenomenon.