Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Carbon nanotubes (CNTs) possess unique mechanical, physical, electrical and absorbability properties coupled with their nanometer dimensional scale that renders them extremely valuable for applications in many fields including nanotechnology and chromatographic separation. The aim of this review is to provide an updated overview about the applications of CNTs in chiral and achiral separations of pharmaceuticals, biologics and chemicals. Chiral single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) have been directly applied for the enantioseparation of pharmaceuticals and biologicals by using them as stationary or pseudostationary phases in chromatographic separation techniques such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and gas chromatography (GC). Achiral MWCNTs have been used for achiral separations as efficient sorbent objects in solid-phase extraction techniques of biochemicals and drugs. Achiral SWCNTs have been applied in achiral separation of biological samples. Achiral SWCNTs and MWCNTs have been also successfully used to separate achiral mixtures of pharmaceuticals and chemicals. Collectively, functionalized CNTs have been indirectly applied in separation science by enhancing the enantioseparation of different chiral selectors whereas non-functionalized CNTs have shown efficient capabilities for chiral separations by using techniques such as encapsulation or immobilization in polymer monolithic columns.
Probabilistic Theories of Causality

This chapter provides an overview of a range of probabilistic theories of causality, including those of Reichenbach, Good and Suppes, and the contemporary causal net approach. It discusses two key problems for probabilistic accounts: counterexamples to these theories and their failure to account for the relationship between causality and mechanisms. It is argued that to overcome the problems, an epistemic theory of causality is required.
Effect of Location Accuracy and Shadowing on the Probability of Non-Interfering Concurrent Transmissions in Cognitive Ad Hoc Networks

Cognitive radio ad hoc systems can coexist with a primary network in a scanning-free region, which can be dimensioned by location awareness. This coexistence of networks improves system throughput and increases the efficiency of radio spectrum utilization. However, the location accuracy of real positioning systems affects the right dimensioning of the concurrent transmission region. Moreover, an ad hoc connection may not be able to coexist with the primary link due to the shadowing effect. In this paper we investigate the impact of location accuracy on the concurrent transmission probability and analyze the reliability of concurrent transmissions when shadowing is taken into account. A new analytical model is proposed, which allows to estimate the resulting secure region when the localization uncertainty range is known. Computer simulations show the dependency between the location accuracy and the performance of the proposed topology, as well as the reliability of the resulting secure region.
HOUSING WEALTH REALLOCATION BETWEEN SUBPRIME AND PRIME BORROWERS DURING RECESSIONS

The Survey of Consumer Finances (SCF) indicates that, unlike subprime borrowers, prime borrowers are more likely to own investment homes during recessions than during recoveries. Drawing on this empirical fact, we present and estimate a dynamic stochastic general equilibrium (DSGE) model that distinguishes between borrowers through their credit access. We find that the relative ease of credit access among borrowers explains the divergence in investment homeownership seen in the data. This divergence is amplified when subprime borrowers are subject to lax credit conditions prior to a financial shock or when the nominal interest rate is constrained at the zero lower bound (ZLB). An expansionary monetary policy helps bridge this gap across borrowers.
Spot on for liars! How public scrutiny influences ethical behavior

We examine whether people are more honest in public than in private. In a laboratory experiment, we have subjects roll dice and report outcomes either in public or in private. Higher reports yield more money and lies cannot be detected. We also elicit subjects’ ethical mindsets and their expectations about others’ reports. We find that outcome-minded subjects lie less in public to conform with their expectations about others’ reports. Ironically, these expectations are false. Rule-minded subjects, in turn, do not respond to public scrutiny. These findings challenge the common faith in public scrutiny to promote ethical behavior. While public scrutiny eventually increases honesty, this effect is contingent on people’s mindsets and expectations.
Reconstructing Software High-Level Architecture by Clustering Weighted Directed Class Graph

Software architecture reconstruction plays an important role in software reuse, evolution and maintenance. Clustering is a promising technique for software architecture reconstruction. However, the representation of software, which serves as clustering input, and the clustering algorithm need to be improved in real applications. The representation should contain appropriate and adequate information of software. Furthermore, the clustering algorithm should be adapted to the particular demands of software architecture reconstruction well. In this paper, we first extract Weighted Directed Class Graph (WDCG) to represent object-oriented software. WDCG is a structural and quantitative representation of software, which contains not only the static information of software source code but also the dynamic information of software execution. Then we propose a WDCG-based Clustering Algorithm (WDCG-CA) to reconstruct high-level software architecture. WDCG-CA makes full use of the structural and quantitative information of WDCG, and avoids wrong compositions and arbitrary partitions successfully in the process of reconstructing software architecture. We introduce four metrics to evaluate the performance of WDCG-CA. The results of the comparative experiments show that WDCG-CA outperforms the comparative approaches in most cases in terms of the four metrics.
Temporal changes of soil physic-chemical properties at different soil depths during larch afforestation by multivariate analysis of covariance

Soil physic-chemical properties differ at different depths; however, differences in afforestation-induced temporal changes at different soil depths are seldom reported. By examining 19 parameters, the temporal changes and their interactions with soil depth in a large chronosequence dataset (159 plots; 636 profiles; 2544 samples) of larch plantations were checked by multivariate analysis of covariance (MANCOVA). No linear temporal changes were found in 9 parameters (N, K, N:P, available forms of N, P, K and ratios of N: available N, P: available P and K: available K), while marked linear changes were found in the rest 10 parameters. Four of them showed divergent temporal changes between surface and deep soils. At surface soils, changing rates were 262.1 g·kg−1·year−1 for SOM, 438.9 mg·g−1·year−1 for C:P, 5.3 mg·g−1·year−1 for C:K, and −3.23 mg·cm−3·year−1 for bulk density, while contrary tendencies were found in deeper soils. These divergences resulted in much moderated or no changes in the overall 80-cm soil profile. The other six parameters showed significant temporal changes for overall 0–80-cm soil profile (P: −4.10 mg·kg−1·year−1; pH: −0.0061 unit·year−1; C:N: 167.1 mg·g−1·year−1; K:P: 371.5 mg·g−1 year−1; N:K: −0.242 mg·g−1·year−1; EC: 0.169 μS·cm−1·year−1), but without significant differences at different soil depths (P > 0.05). Our findings highlight the importance of deep soils in studying physic-chemical changes of soil properties, and the temporal changes occurred in both surface and deep soils should be fully considered for forest management and soil nutrient balance.
Architecture driven k-way partitioning for multichip modules

A new k-way partitioning approach for multichip modules (MCM) is described. We apply an analytical technique combined with a problem-specific multi-way ratio cut method. Our method considers fired MCM pad positions on the substrate border and assigns the cells to regularly arranged chips on the substrate. For the first time, k-way partitioning results of benchmark circuits with up to 100,000 cells are presented. They show an excellent solution quality in terms of cut nets as well as a low maximum and average number of required chip-level pads for each chip. The average improvement of the number of cut nets compared to a recently published eigenvector-tabu-search approach is about 25%. <<ETX>>
Usability versus Actability: A Conceptual Comparative Analysis

Actability has been proposed as an important information system quality ‘metric’ – a concept that builds on usability to take the social context of human-computer interaction into account. Our objective here has been explicitly to compare usability with actability, and in doing so we have identified both similarities and differences between the two concepts. Actability seems to be narrower in the sense that it focuses on the use of information technology specifically within the context of doing business. However, within that context, it applies a broader perspective on the meaning and purpose of using.
Persistence of replication-competent HIV in both memory and naive CD4 T cell subsets in patients on prolonged and effective HAART

Objective: To investigate the phenotypic features of infected lymphocytes in patients on prolonged and effective highly active antiretroviral therapy (HAART). Design: We examined highly purified subsets of memory and naive CD4 T lymphocytes for the presence of replication-competent virus. Methods: In 11 highly selected HAART-treated patients, we isolated highly purified CD45RO CD45RA CD4 T cells using a magnetic bead-based procedure. In some patients, a subsequent cell separation according to CD62L expression was performed. We quantified total viral DNA in freshly isolated T-cell subsets. To verify whether the virus was replication-competent, HIV RNA was measured in supernatants following cell activation. Results: HIV DNA was detectable in the CD45RO and CD45RA CD4 T-cell subsets in 100% and 90% of the patients tested, respectively. In central memory CD45ROCD62L, effector memory CD45RO+CD62L−, truly naive CD45RACD62L, and CD45RA+CD62L− CD4 T cells, HIV DNA was found in 100%, 55%, 88%, and 50% of the patients tested respectively. HIV DNA was significantly higher in the CD45RO fraction than in the CD45RA subset and in the CD45ROCD62L fraction than in the three other CD45RA/ROCD62L+/− subsets. Detectable HIV RNA was found in the culture supernatants of CD45RO and CD45RA CD4 T-cell subsets in 80% and 66% of the patients tested respectively, and in CD45ROCD62L, CD45RO+CD62L−, CD45RACD62L, and CD45RA+CD62L− CD4 T cells in 100%, 100%, 100% and 50% of the patients tested respectively. Conclusions: In patients on prolonged and effective HAART, the pool of infected CD4 T lymphocytes consists predominantly of memory cells but also contains naive cells.
Joint design of block source codes and modulation signal sets

The problem of designing block source codes and modulation signal sets that are both energy and bandwidth constrained is considered. For the class of linear estimator-based decoders, necessary conditions for optimality for the encoder, decoder and modulation signal set are derived. An algorithm that iteratively solves these necessary conditions to converge to a locally optimum solution has been developed. By studying the performance of the previous class of digital communication systems in the limit of infinite encoding rates, it is demonstrated that the MSE of a bandwidth and energy constrained digital system is bounded from below by that of a block pulse amplitude modulation system. This bound is readily computable in terms of the eigenvalues of the source and channel covariance matrices. The results indicate that for a correlated source, a sufficiently noisy channel and specific source block sizes and bandwidths, the digital system performance coincides with the optimum performance theoretically attainable. Further, significant performance improvements over the standard VQ-based system are demonstrated when the channel is noisy. >
Neurological Evidence Linguistic Processes Precede Perceptual Simulation in Conceptual Processing

There is increasing evidence from response time experiments that language statistics and perceptual simulations both play a role in conceptual processing. In an EEG experiment we compared neural activity in cortical regions commonly associated with linguistic processing and visual perceptual processing to determine to what extent symbolic and embodied accounts of cognition applied. Participants were asked to determine the semantic relationship of word pairs (e.g., sky – ground) or to determine their iconic relationship (i.e., if the presentation of the pair matched their expected physical relationship). A linguistic bias was found toward the semantic judgment task and a perceptual bias was found toward the iconicity judgment task. More importantly, conceptual processing involved activation in brain regions associated with both linguistic and perceptual processes. When comparing the relative activation of linguistic cortical regions with perceptual cortical regions, the effect sizes for linguistic cortical regions were larger than those for the perceptual cortical regions early in a trial with the reverse being true later in a trial. These results map upon findings from other experimental literature and provide further evidence that processing of concept words relies both on language statistics and on perceptual simulations, whereby linguistic processes precede perceptual simulation processes.
Anatomical, biochemical, and photosynthetic responses to recent allopolyploidy in Glycine dolichocarpa (Fabaceae).

PREMISE OF THE STUDY Previous studies have shown that polyploidy has pronounced effects on photosynthesis. Most of these studies have focused on synthetic or recently formed autopolyploids, and comparatively little is known about the integrated effects of natural allopolyploidy, which involves hybridity and genome doubling and often incorporates multiple genotypes through recurrent origins and lineage recombination. METHODS Glycine dolichocarpa (designated T2) is a natural allotetraploid with multiple origins. We quantified 21 anatomical, biochemical, and physiological phenotypes relating to photosynthesis in T2 and its diploid progenitors, G. tomentella (D3) and G. syndetika (D4). To assess how direction of cross affects these phenotypes, we included three T2 accessions having D3-like plastids (T2(D3)) and two accessions having D4-like plastids (T2(D4)). KEY RESULTS T2 accessions were transgressive (more extreme than any diploid accession) for 17 of 21 phenotypes, and species means differed significantly in T2 vs. both progenitors for four of 21 phenotypes (higher for guard cell length, electron transport capacity [J(max)] per palisade cell, and J(max) per mesophyll cell; lower for palisade cells per unit leaf area). Within T2, four of 21 parameters differed significantly between T2(D3) and T2(D4) (palisade cell volume; chloroplast number and volume per unit leaf area; and J(max) per unit leaf area). CONCLUSIONS T2 is characterized by transgressive photosynthesis-related phenotypes (including an ca. 2-fold increase in J(max) per cell), as well as by significant intraspecies variation correlating with plastid type. These data indicate prominent roles for both nucleotypic effects and cytoplasmic factors in photosynthetic responses to allopolyploidy.
Towards a better understanding of the physical properties of lining materials for paintings: Interim results

Abstract This paper reports on a preliminary investigation into the biaxial properties of a selection of traditional and modern materials which could be used in the lining of paintings on canvas. It describes their load response to high levels of moisture and their load‐extension behaviour when under biaxial restraint. All the woven lining materials tested were found to be anisotropic and to have load‐extension curves with characteristic features: non‐linear load‐extension, hysterisis and creep. The role of crimp in determining mechanical properties and anisotropy of these materials is discussed. Preliminary observations on the application of these findings to practice are given.
The Concurrent Language Aldwych

Aldwych is proposed as the foundation of a general purpose language for parallel applications. It works on a rule-based principle, and has aspects variously of concurrent functional, logic and object-oriented languages, yet it forms an integrated whole. It is intended to be applicable both for small-scale parallel programming, and for large-scale open systems.
The Differences in Health Care Utilization between Medical Aid and Health Insurance: A Longitudinal Study Using Propensity Score Matching

Study Objectives Health care utilization has progressively increased, especially among Medical Aid beneficiaries in South Korea. The Medical Aid classifies beneficiaries into two categories, type 1 and 2, on the basis of being incapable (those under 18 or over 65 years of age, or disabled) or capable of working, respectively. Medical Aid has a high possibility for health care utilization due to high coverage level. In South Korea, the national health insurance (NHI) achieved very short time to establish coverage for the entire Korean population. However there there remaine a number of problems to be solved. Therefore, the objective of this study was to investigate the differences in health care utilization between Medical Aid beneficiaries and Health Insurance beneficiaries. Methods & Design Data were collected from the Korean Welfare Panel Study from 2008 to 2012 using propensity score matching. Of the 2,316 research subjects, 579 had Medical Aid and 1,737 had health insurance. We also analyzed three dependent variables: days spent in the hospital, number of outpatient visits, and hospitalizations per year. Analysis of variance and longitudinal data analysis were used. Results The number of outpatient visits was 1.431 times higher (p<0.0001) in Medical Aid beneficiaries, the number of hospitalizations per year was 1.604 times higher (p<0.0001) in Medical Aid beneficiaries, and the number of days spent in the hospital per year was 1.282 times higher (p<0.268) for Medical Aid beneficiaries than in individuals with Health Insurance. Medical Aid patients had a 0.874 times lower frequency of having an unmet needs due to economic barrier (95% confidence interval: 0.662-1.156). Conclusions Health insurance coverage has an impact on health care utilization. More health care utilization among Medical Aid beneficiaries appears to have a high possibility of a moral hazard risk under the Health Insurance program. Therefore, the moral hazard for Medical Aid beneficiaries should be avoided.
A Physics-Based Integrated Model of a Spark Ignition Engine and a Three-Way Catalyst

This article proposes an integrated model of a spark ignition engine, the exhaust system, and a three-way catalyst. The model can calculate instantaneous fuel consumption, as well as CO, NO, and HC tailpipe emissions under transient driving conditions. Where practical, this model is based on physical principles to improve its portability and reduce the calibration required. The model is calibrated using fully warm, steady state engine maps and the results of a single transient test of the engine and exhaust system. It is then validated over the New European Drive Cycle and cold start Extra Urban Drive Cycle. Tradeoffs between model accuracy and model complexity are then examined by progressively reducing the order of the proposed model. The accuracy of some lower-order model formulations is shown to be acceptable, suggesting that such a model may be sufficiently fast and accurate for use in dynamic optimization.
The Cost Implications of Less Tight Versus Tight Control of Hypertension in Pregnancy (CHIPS Trial)

The CHIPS randomized controlled trial (Control of Hypertension in Pregnancy Study) found no difference in the primary perinatal or secondary maternal outcomes between planned “less tight” (target diastolic 100 mm Hg) and “tight” (target diastolic 85 mm Hg) blood pressure management strategies among women with chronic or gestational hypertension. This study examined which of these management strategies is more or less costly from a third-party payer perspective. A total of 981 women with singleton pregnancies and nonsevere, nonproteinuric chronic or gestational hypertension were randomized at 14 to 33 weeks to less tight or tight control. Resources used were collected from 94 centers in 15 countries and costed as if the trial took place in each of 3 Canadian provinces as a cost-sensitivity analysis. Eleven hospital ward and 24 health service costs were obtained from a similar trial and provincial government health insurance schedules of medical benefits. The mean total cost per woman–infant dyad was higher in less tight versus tight control, but the difference in mean total cost (DM) was not statistically significant in any province: Ontario ($30 191.62 versus $24 469.06; DM $5723, 95% confidence interval, −$296 to $12 272; P=0.0725); British Columbia ($30 593.69 versus $24 776.51; DM $5817; 95% confidence interval, −$385 to $12 349; P=0.0725); or Alberta ($31 510.72 versus $25 510.49; DM $6000.23; 95% confidence interval, −$154 to $12 781; P=0.0637). Tight control may benefit women without increasing risk to neonates (as shown in the main CHIPS trial), without additional (and possibly lower) cost to the healthcare system. Clinical Trial Registration—URL: http://www.clinicaltrials. gov. Unique identifier: NCT01192412.