Miracle-dz/UniFAR-FTUs huggingface dataset:
Modelling the [Fe II] λ1.644 μm outflow and comparison with H2 and H+ kinematics in the inner 200 pc of NGC 1068

We map the kinematics of the inner (200 pc) narrow-line region (NLR) of the Seyfert 2 galaxy NGC 1068 using the instrument NIFS and adaptative optics at the Gemini North Telescope. Channel maps and position-velocity diagrams are presented at a spatial resolution of $\sim$ 10 pc and spectral resolution $\sim$ 5300 in the emission lines [Fe II] {\lambda} 1.644 {\mu}m, H$_2$ {\lambda} 2.122 {\mu}m and Br{\gamma}. The [Fe II] emission line provides a better coverage of the NLR outflow than the previously used [O III] {\lambda} 5007 emission line, extending beyond the area of the bi-polar cone observed in Br{\gamma} and [O III]. This is mainly due to the contribution of the redshifted channels to the NE of the nucleus, supporting its origin in a partial ionized zone with additional contribution from shocks of the outflowing gas with the galactic disc. We modeled the kinematics and geometry of the [Fe II] emitting gas finding good agreement with the data for outflow models with conical and lemniscate (or hourglass) geometry. We calculate a mass outflow rate $1.9^{+1.9}_{-0.7}$ M$_{\odot}~$yr$^{-1}$ but a power for the outflow of only 0.08% L$_{Bol}$. The molecular (H$_2$) gas kinematics is completely distinct from that of [Fe II] and Br{\gamma}, showing radial expansion in an off-centered $\sim$ 100 pc radius ring in the galaxy plane. The expansion velocity decelerates from $\sim$ 200 km/s in the inner border of the ring to approximately zero at the outer border where our previous studies found a 10 Myr stellar population.
Kin discrimination via odour in the cooperatively breeding banded mongoose

Kin discrimination is often beneficial for group-living animals as it aids in inbreeding avoidance and providing nepotistic help. In mammals, the use of olfactory cues in kin discrimination is widespread and may occur through learning the scents of individuals that are likely to be relatives, or by assessing genetic relatedness directly through assessing odour similarity (phenotype matching). We use scent presentations to investigate these possibilities in a wild population of the banded mongoose Mungos mungo, a cooperative breeder in which inbreeding risk is high and females breed communally, disrupting behavioural cues to kinship. We find that adults show heightened behavioural responses to unfamiliar (extra-group) scents than to familiar (within-group) scents. Interestingly, we found that responses to familiar odours, but not unfamiliar odours, varied with relatedness. This suggests that banded mongooses are either able to use an effective behavioural rule to identify likely relatives from within their group, or that phenotype matching is used in the context of within-group kin recognition but not extra-group kin recognition. In other cooperative breeders, familiarity is used within the group and phenotype matching may be used to identify unfamiliar kin. However, for the banded mongoose this pattern may be reversed, most likely due to their unusual breeding system which disrupts within-group behavioural cues to kinship.
Effect of bioactive modified nonwoven systems on the development of house dust mites Dermatophagoides farinae (Acari: Pyroglyphidae) in laboratory assay

Limiting the exposure to house dust mite allergens requires integrated approaches and suitable design, and bio-modified textile materials may be used as an element of the complex anti-dust mite protection. The aim of this work was to study the effects of nonwoven systems modified with triclosan on the development of Dermatophagoides farinae house dust mites in laboratory assay. Two four-layer nonwoven polypropylene systems were designed: A – two inner meltblown nonwovens and two outer spun-bonded nonwovens and B – an inner spun-bonded nonwoven, an inner needle-felt nonwoven, an inner meltblown nonwoven, and an outer spun-bonded nonwoven. Bioactive microspheres consisting of poly(L-lactide) (95 wt%) and triclosan (5 wt%) were used. Both systems were modified using dispersion with 2.5 wt% and 10 wt% of microspheres, which corresponds to the content of 0.26 wt% and 1.22 wt% of triclosan in nonwoven samples. The culture tests were performed for modified and unmodified nonwoven samples and the control sample. The anti-dust mite properties were assessed based on the mortality of mites. All modified nonwoven systems showed a strong suppressive effect on the tested Dermatophagoides farinae, compared to the control sample. A higher mortality was observed for nonwoven system B. It was found that a nearly five-fold increase in the triclosan concentration does not lead to a substantial increase in the decline rate of mite populations.
Elevated nucleus accumbens structural connectivity associated with proneness to hypomania: a reward hypersensitivity perspective

Abstract The Reward Hypersensitivity Model of bipolar disorder argues that hypersensitivity to reward-relevant cues characterizes risk for hypo/mania. This hypersensitivity leads to increased goal-directed motivation during reward-relevant life events that, in the extreme, is reflected in hypo/manic symptoms. In line with this perspective, individuals with bipolar disorder display elevated activation in a cortico-striatal reward circuit including the nucleus accumbens (NAcc) and medial orbitofrontal cortex (mOFC). To date, however, research on reward-related neural circuitry underlying bipolar symptoms focuses on syndromal bipolar disorder (bipolar I, bipolar II), and typically examines neural regions in isolation of each other. Accordingly, this study examines the relationship between subsyndromal hypo/mania proneness and structural connectivity between the NAcc and both the mOFC and amygdala in a medication-free sample. Fifty-four community participants completed diffusion-weighted imaging and a self-report measure of bipolar risk (hypo/mania proneness). As predicted, elevated structural connectivity between the NAcc and both the mOFC and amygdala were associated with elevated hypo/mania proneness. This relationship was specific to NAcc-centered reward connectivity, as there was no relationship between hypo/mania proneness and either whole-brain or cortico-amygdala connectivity. Results suggest that reward-relevant tractography from cortical (mOFC) and subcortical (amygdala) regions amplify NAcc-centered reward processing in bipolar risk.
Non-Gaussian Velocity Distributions in Solar Flares from Extreme Ultraviolet Lines: A Possible Diagnostic of Ion Acceleration

In a solar flare, a large fraction of the magnetic energy released is converted rapidly to the kinetic energy of non-thermal particles and bulk plasma motion. This will likely result in non-equilibrium particle distributions and turbulent plasma conditions. We investigate this by analyzing the profiles of high temperature extreme ultraviolet emission lines from a major flare (SOL2014-03-29T17:44) observed by the EUV Imaging Spectrometer (EIS) on Hinode. We find that in many locations the line profiles are non-Gaussian, consistent with a kappa distribution of emitting ions with properties that vary in space and time. At the flare footpoints, close to sites of hard X-ray emission from non-thermal electrons, the κ index for the Fe xvi 262.976 Å line at 3 MK takes values of 3–5. In the corona, close to a low-energy HXR source, the Fe xxiii 263.760 Å line at 15 MK shows κ values of typically 4–7. The observed trends in the κ parameter show that we are most likely detecting the properties of the ion population rather than any instrumental effects. We calculate that a non-thermal ion population could exist if locally accelerated on timescales ≤0.1 s. However, observations of net redshifts in the lines also imply the presence of plasma downflows, which could lead to bulk turbulence, with increased non-Gaussianity in cooler regions. Both interpretations have important implications for theories of solar flare particle acceleration.
Functional impairment matters in the screening and diagnosis of gaming disorder

This commentary responds to Aarseth et al.’s (in press) criticisms that the ICD-11 Gaming Disorder proposal would result in “moral panics around the harm of video gaming” and “the treatment of abundant false-positive cases. ” The ICD-11 Gaming Disorder avoids potential “overpathologizing” with its explicit reference to functional impairment caused by gaming and therefore improves upon a number of flawed previous approaches to identifying cases with suspected gaming-related harms. We contend that moral panics are more likely to occur and be exacerbated by misinformation and lack of understanding, rather than proceed from having a clear diagnostic system.
Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder

Abstract Recent emotion dysregulation models of generalized anxiety disorder (GAD) propose chronic worry in GAD functions as a maladaptive attempt to regulate anxiety related to uncertain or unpredictable outcomes. Emotion acceptance is an adaptive emotion regulation strategy increasingly incorporated into newer cognitive behavioral therapy (CBT) approaches to GAD to counter chronic worry. The current study explores the mechanisms of emotion acceptance as an alternate emotion regulation strategy to worry or emotion suppression using functional magnetic resonance imaging. Twenty-one female participants diagnosed with GAD followed counterbalanced instructions to regulate responses to personally relevant worry statements by engaging in either emotion acceptance, worry or emotion suppression. Emotion acceptance resulted in lower ratings of distress than worry and was associated with increased dorsal anterior cingulate cortex (dACC) activation and increased ventrolateral prefrontal cortex (VLPFC)-amygdala functional connectivity. In contrast, worry showed significantly greater distress ratings than acceptance or suppression and was associated with increased precuneus, VLPFC, amygdala and hippocampal activation. Suppression did not significantly differ from acceptance in distress ratings or amygdala recruitment, but resulted in significantly greater insula and VLPFC activation and decreased VLPFC-amygdala functional connectivity. Emotion acceptance closely aligned with activation and connectivity patterns reported in studies of contextual extinction learning and mindful awareness.
New Trends in the Therapeutic Approach to Metastatic Colorectal Cancer

Important developments in chemotherapy for metastatic colorectal cancer over the last years are reviewed, with an emphasis on the most recently published data from clinical trials. The systematic review of current literature was conducted involving Pubmed Central® research and full articles were obtained and analyzed when appropriate. Fluorouracil still constitutes the backbone of metastatic colorectal cancer treatment; fluorouracil combination plus either irinotecan (FOLFIRI), oxaliplatin (FOLFOX) or capecitabine (CAPOX or XELOX) are chemotherapy protocols established as treatments producing similar outcomes. Actual treatment involves these chemotherapy protocols in combination with new molecular targeted drugs: bevacizumab and aflibercept (anti-vascular endothelial growth factor monoclonal antibody) and cetuximab and panitumumab (anti-epidermal growth factor receptor monoclonal antibody for patients with wild type KRAS) which confer significant survival benefits in select patients as first- or second-line therapies. The factors affecting the decisions for one treatment over other are related to the patient and toxicity drug. Finally, metastatic colorectal cancer patients progressing after all standard therapies (maintaining a good ECOG performance status) could be candidates for further therapies such as regorafenib and TAS-102. Regarding the future, promising therapies are under development for the metastatic colorectal cancer treatment and several agents are currently being evaluated in different clinical trials.
Is it time to leave behind the Revised Hierarchical Model of bilingual language processing after fifteen years of service

The Revised Hierarchical Model (RHM) of bilingual language processing dominates current thinking on bilingual language processing. Recently, basic tenets of the model have been called into question. First, there is little evidence for separate lexicons. Second, there is little evidence for language selective access. Third, the inclusion of excitatory connections between translation equivalents at the lexical level is likely to impede word recognition. Fourth, the connections between L2 words and their meanings are stronger than proposed in RHM. And finally, there is good evidence to make a distinction between language-dependent and language-independent semantic features. It is argued that the Revised Hierarchical Model cannot easily be adapted to incorporate these challenges and that a more fruitful way forward is to start from existing computational models of monolingual language processing and see how they can be adapted for bilingual input and output, as has been done in the Bilingual Interactive Activation model.
Relative validity and reproducibility of a French dietary history questionnaire.

BACKGROUND A self-administered dietary history questionnaire, especially developed for use in a large French prospective cohort study, was tested for accuracy of food intake measurement by comparing it to the average of 9-12 24-hour recalls. This questionnaire was structured according to the French meal pattern. An important feature of the questionnaire was the separation into a quantification part and qualification part. The first part quantifies consumption by frequency and portion sizes per food group or food item. The second part provides more detailed qualitative information on separate items within one food group. The total number of food items in the questionnaire was 238. METHODS The questionnaire was administered twice to 119 study subjects, with an interval of approximately one year (1990-1991). During that year, 24-hour recalls were carried out monthly. Reproducibility and relative validity of the questionnaire were assessed. RESULTS The correlation coefficients for reproducibility ranged from 0.40 to 0.74 for foods and from 0.54 to 0.75 for nutrients. The correlation coefficients for relative validity ranged from 0.10 to 0.71 for foods and from 0.29 to 0.81 for nutrients (adjustment for total energy and attenuation for nutrients). Percentage of subjects classified in the same or adjacent quintile by questionnaire as well as by 24-hour recall was on average 76% for foods and 72% for nutrients. CONCLUSIONS These data indicate that this questionnaire can be used to classify study subjects according to their food or nutrient intake over a one-year period, within a known degree of precision.
Reply to Comment on ‘The case for in situ resource utilisation for oxygen production on Mars by non-equilibrium plasmas’

Herein, it is argued that Mars has nearly ideal conditions for CO2 decomposition by non-equilibrium plasmas. It is shown that the pressure and temperature ranges in the CO2 Martian atmosphere favour the vibrational excitation and subsequent up-pumping of the asymmetric stretching mode, which is believed to be a key factor for an efficient plasma dissociation, at the expense of the excitation of the other modes. Therefore, gas discharges operating at atmospheric pressure on Mars are extremely strong candidates to produce O2 efficiently from the locally available resources.
Resting-state hemodynamics are spatiotemporally coupled to synchronized and symmetric neural activity in excitatory neurons

Significance Resting-state functional connectivity mapping exploits correlations in the functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) signal across the brain. However, results are difficult to interpret without an understanding of the neural correlates of these hemodynamic fluctuations. This work uses mice in which neural activity and brain hemodynamics can be mapped simultaneously. We show that resting-state hemodynamics can be predicted from spontaneous neural activity and correspond to a series of driven increases in local blood volume, coupled with spontaneous, bilaterally symmetric fluctuations in excitatory neural activity. This result provides reassurance that resting-state functional connectivity has neural origins. The network-like spontaneous neural activity visualized here represents an underexplored feature of neural activity in the awake brain. Brain hemodynamics serve as a proxy for neural activity in a range of noninvasive neuroimaging techniques including functional magnetic resonance imaging (fMRI). In resting-state fMRI, hemodynamic fluctuations have been found to exhibit patterns of bilateral synchrony, with correlated regions inferred to have functional connectivity. However, the relationship between resting-state hemodynamics and underlying neural activity has not been well established, making the neural underpinnings of functional connectivity networks unclear. In this study, neural activity and hemodynamics were recorded simultaneously over the bilateral cortex of awake and anesthetized Thy1-GCaMP mice using wide-field optical mapping. Neural activity was visualized via selective expression of the calcium-sensitive fluorophore GCaMP in layer 2/3 and 5 excitatory neurons. Characteristic patterns of resting-state hemodynamics were accompanied by more rapidly changing bilateral patterns of resting-state neural activity. Spatiotemporal hemodynamics could be modeled by convolving this neural activity with hemodynamic response functions derived through both deconvolution and gamma-variate fitting. Simultaneous imaging and electrophysiology confirmed that Thy1-GCaMP signals are well-predicted by multiunit activity. Neurovascular coupling between resting-state neural activity and hemodynamics was robust and fast in awake animals, whereas coupling in urethane-anesthetized animals was slower, and in some cases included lower-frequency (<0.04 Hz) hemodynamic fluctuations that were not well-predicted by local Thy1-GCaMP recordings. These results support that resting-state hemodynamics in the awake and anesthetized brain are coupled to underlying patterns of excitatory neural activity. The patterns of bilaterally-symmetric spontaneous neural activity revealed by wide-field Thy1-GCaMP imaging may depict the neural foundation of functional connectivity networks detected in resting-state fMRI.
Completing the Banking Union with a European Deposit Insurance Scheme: Who is Afraid of Cross-Subsidisation?

This paper investigates the impact and appropriateness of establishing a fully mutualized European deposit insurance scheme (EDIS) using a unique supervisory micro-level data set on euro area banks’ covered deposits and their other liabilities. We find that an ex-ante funded deposit insurance fund (DIF) with a target size of 0.8% of euro area covered deposits would be sufficient to cover losses even in a severe banking crisis. We then derive risk-based contributions to the DIF based on the different bank- and country-specific factors, showing that they can take into account the relative riskiness of banks and banking systems to tackle moral hazard. We also find that smaller and larger banks would not excessively contribute to EDIS relative to the amount of covered deposits in their balance sheet. Finally, we show that there would be no unwarranted systematic cross-subsidization within EDIS in the sense of some banking systems systematically contributing less than they would benefit from the DIF.
Atmospheric brown clouds reach the Tibetan Plateau by crossing the Himalayas

Abstract. The Himalayas and the Tibetan Plateau region (HTP), despite being a remote and sparsely populated area, is regularly exposed to polluted air masses with significant amounts of aerosols including black carbon. These dark, light-absorbing particles are known to exert a great melting potential on mountain cryospheric reservoirs through albedo reduction and radiative forcing. This study combines ground-based and satellite remote sensing data to identify a severe aerosol pollution episode observed simultaneously in central Tibet and on the southern side of the Himalayas during 13–19 March 2009 (pre-monsoon). Trajectory calculations based on the high-resolution numerical weather prediction model COSMO are used to locate the source regions and study the mechanisms of pollution transport in the complex topography of the HTP. We detail how polluted air masses from an atmospheric brown cloud (ABC) over South Asia reach the Tibetan Plateau within a few days. Lifting and advection of polluted air masses over the great mountain range is enabled by a combination of synoptic-scale and local meteorological processes. During the days prior to the event, winds over the Indo-Gangetic Plain (IGP) are generally weak at lower levels, allowing for accumulation of pollutants and thus the formation of ABCs. The subsequent passing of synoptic-scale troughs leads to southwesterly flow in the middle troposphere over northern and central India, carrying the polluted air masses across the Himalayas. As the IGP is known to be a hotspot of ABCs, the cross-Himalayan transport of polluted air masses may have serious implications for the cryosphere in the HTP and impact climate on regional to global scales. Since the current study focuses on one particularly strong pollution episode, quantifying the frequency and magnitude of similar events in a climatological study is required to assess the total impact.
Role of intrauterine tubo-peritoneal insemination and intrauterine insemination in the treatment of infertility

Background: Infertility management has become more substantial and relevant with an increase in the number of infertile patients as well as advances in the science of reproduction. The objective of our study was to assess the role of intrauterine tuboperitoneal insemination (IUTPI) and intrauterine insemination (IUI) in the treatment of infertile patients. Methods: 236 infertile patients, 118 in each group attending the infertility clinic, after applying both inclusion and exclusion criteria were enrolled in the present study. Patients in each study group were given clomiphene citrate for ovarian stimulation followed by injection hCG for triggering ovulation. Insemination with washed husband’s sperm was performed about 36-40 hours after hCG administration, using 10ml of inseminate in IUTPI and 0.5ml inseminate in IUI. The patient was then called after 2 weeks for urine pregnancy test (UPT) which, if positive was considered as clinical pregnancy. Results: Out of the total 236 cases, 42 cases had a positive outcome. Out of these 42 positive cases, 27 were from IUTPI group whereas 15 from IUI group. The pregnancy rate was 22.88% in IUTPI and 12.71% in IUI (p=0.039), which was a statistically significant difference. Endometrial thickness, preovulatory follicle number and prewash sperm motility significantly affected positive outcome in IUTPI. Factors like patient’s age, BMI<25, bilateral patent tubes and decreased duration of infertility also positively affected the treatment outcome. Conclusions: Our study found IUTPI to have better pregnancy rate compared to IUI. IUTPI may become a first line option for treatment of infertile patients.