Miracle-dz/UniFAR-FTUs huggingface dataset:
Corticospinal System Development Depends on Motor Experience

Early motor experiences have been shown to be important for the development of motor skills in humans and animals. However, little is known about the role of motor experience in motor system development. In this study, we address the question of whether early motor experience is important in shaping the development of the corticospinal (CS) tract. We prevented limb use by the intramuscular injection of botulinum toxin A into selected forelimb muscles to produce muscle paralysis during the period of development of CS connection specificity, which is between postnatal weeks 3 and 7. CS terminations were examined using an anterograde tracer. Preventing normal forelimb use during CS axon development produced defective development of CS terminations at week 8 and in maturity. There were reductions in the topographic distribution of axon terminals, in terminal and preterminal branching, and in varicosity density. This suggests that limb use is needed to refine CS terminals into topographically specific clusters of dense terminal branches and varicosities. To determine correlated effects on motor behavior, cats were tested in a prehension task, to reach and grasp a piece of food from a narrow food well, when the neuromuscular blockade dissipated (by week 10) and in maturity (week 16). Preventing normal limb use also produced a prehension deficit later in development and in maturity, in which there was a loss of the supination component of grasping. This component of prehension in the cat depends on CS projections from the paw representation of rostral motor cortex to the cervical enlargement. Our findings show that motor experiences are necessary for normal development of CS terminations and function.
Correlation between Myocardial Dysfunction and Perfusion Impairment in Diabetic Rats with Velocity Vector Imaging and Myocardial Contrast Echocardiography

The purpose of this study was to investigate whether myocardial systolic dysfunction and perfusion impairment occur in diabetic rats, and to assess their relationship using velocity vector imaging (VVI) and myocardial contrast echocardiography (MCE). Forty‐six rats were randomly divided into either control or the diabetes mellitus (DM) groups. DM was induced by intraperitoneal administration of streptozotocin. Twelve weeks later, 39 survival rats underwent VVI and MCE in short‐axis view at the middle level of the left ventricle, both at rest and after dipyridamole stress. VVI‐derived contractile parameters included peak systolic velocity (Vs), circumferential strain (εc), strain rate (SRc), and their reserves. MCE‐derived perfusion parameters consisted of myocardial blood flow (MBF) and myocardial flow reserve (MFR). At rest, SRc in the DM group was significantly lower than in the control group, Vs, εc, and MBF did not differ significantly between groups. After dipyridamole stress, all VVI parameters and their reserves in the DM group were significantly lower than those in the control group, MBF and MFR were substantially lower than those in the control group, too. Meanwhile, significant correlations between VVI parameter reserves and MFR were observed in the DM group. Both myocardial systolic function and perfusion were impaired in DM rats. Decreased MFR could be an important contributor to the reduction in myocardial contractile reserve.
Prevalence of Scoliosis in Neurofibromatosis

Experience in a comprehensive, multispecialty neurofibromatesis clinic leads the authors to suggest that the association of spinal deformity with neurofibromatosis is less frequent than usually assumed. Previously reported statistics may be partly attributed to preselection of patients seen by spinal surgeons, and to the predominant referral of patients having severe manifestations of neurofibromatosis. A diagnosis of neurofibromatosis 1, based on National Institutes of Health criteria, is confirmed for two hundred twenty patients at the clinic. Twenty-three of these patients have structural scoliosis. Nine patients have idiopathic type curves, eight have dystrophic scoliosis, four have dystrophic kyphoscoliosis, and two have dystrophic lordoscotiosis. The authors believe that 10% is representative of the true prevalence of spinal deformity in an otherwise unselected cross section of neurofibromatosis patients.
Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis

Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was performed on 202 PTB patients and 204 healthy individuals. Genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The results indicated that neither miRNA-499 rs3746444 nor miRNA-146a rs2910164 are associated with the risk of PTB in a sample of Iranian population. Larger studies with different ethnicities are required to validate our findings.
Relationship of Productivity to Species Richness in the Xinjiang Temperate Grassland

The relationship between species richness (SR) and aboveground net primary productivity (ANPP) is still a central and debated issue in community ecology. Previous studies have often emphasized the relationship of alpha diversity (number of species identity) to the mean ANPP with respect to the SR-ANPP relationship while neglecting the contribution of beta diversity (dissimilarity in species composition) to the mean ANPP and to the stability of ANPP (coefficient of ANPP: CV of ANPP). In this study, we used alpha and beta diversity, mean ANPP and the CV of ANPP collected from 159 sites and belonging to three vegetation types in the Xinjiang temperate grassland to first examine their trends along climatic factors and among different vegetation types and then test the relationship among alpha (beta) diversity and mean ANPP and the CV of ANPP. Our results showed that in the Xinjiang temperate grasslands, alpha diversity was positively and linearly correlated with MAP but unimodally correlated with MAT. Meanwhile, beta diversity was unimodally correlated with MAP but linearly correlated with MAT. Relative to desert steppe, meadow steppe and typical steppe had the highest alpha and beta diversity, respectively. Except for ANPP exhibiting a quadratic relationship with MAP, no significant relationship was found among ANPP, the CV of ANPP and climatic factors. ANPP and the CV of ANPP also exhibited no apparent patterns in variation among different vegetation types. Our results further showed that mean ANPP was closely associated with alpha diversity. Both linear and unimodal relationships were detected between alpha diversity and mean ANPP, but their particular form was texture-dependent. Meanwhile, the CV of ANPP was positively correlated with beta diversity. Our results indicated that in addition to incorporating alpha diversity and mean ANPP, incorporating beta diversity and the CV of ANPP could expand our understanding of the SR-ANPP relationship.
Hypertension knowledge among patients from an urban clinic.

OBJECTIVE To determine levels and correlates of hypertension knowledge. DESIGN Cross-sectional telephone survey. SETTING Urban, public hospital clinic. PARTICIPANTS 296 adults with hypertension. MAIN OUTCOME MEASURE Hypertension knowledge was assessed through a 10-item test; respondents received one point for each correct answer. RESULTS Eighty-nine percent of respondents were Black, 79% were female, 75% had a monthly income < $1000, and 62% had completed high school. Items with the lowest percentage of correct responses included knowing that hypertension does not cause cancer (41.9% correct), a blood pressure of 130/80 mm Hg is normal (59.8% correct), hypertension lasts a lifetime (60.5% correct), and renal failure is a complication of hypertension (76.4% correct). Overall, 39% answered 9 or 10 questions correctly. Low hypertension knowledge (< or = 7 questions correct) was associated with age > or = 60 years, having less than a high school education, and reporting a first hypertension diagnosis within 9 years before being surveyed. CONCLUSIONS Hypertension knowledge deficits in specific content areas and among certain subgroups were present in this urban population. Educational programs focusing on newly diagnosed hypertensive patients and aimed at filling targeted knowledge deficits may be a cost-effective approach to increase hypertension knowledge in similar populations.
Rosaceae Fruit Development, Ripening and Post-harvest: An Epigenetic Perspective

Rosaceae is a family with an extraordinary spectrum of fruit types, including fleshy peach, apple, and strawberry that provide unique contributions to a healthy diet for consumers, and represent an excellent model for studying fruit patterning and development. In recent years, many efforts have been made to unravel regulatory mechanism underlying the hormonal, transcriptomic, proteomic and metabolomic changes occurring during Rosaceae fruit development. More recently, several studies on fleshy (tomato) and dry (Arabidopsis) fruit model have contributed to a better understanding of epigenetic mechanisms underlying important heritable crop traits, such as ripening and stress response. In this context and summing up the results obtained so far, this review aims to collect the available information on epigenetic mechanisms that may provide an additional level in gene transcription regulation, thus influencing and driving the entire Rosaceae fruit developmental process. The whole body of information suggests that Rosaceae fruit could become also a model for studying the epigenetic basis of economically important phenotypes, allowing for their more efficient exploitation in plant breeding.
Efficient MRF Energy Minimization via Adaptive Diminishing Smoothing

We consider the linear programming relaxation of an energy minimization problem for Markov Random Fields. The dual objective of this problem can be treated as a concave and unconstrained, but non-smooth function. The idea of smoothing the objective prior to optimization was recently proposed in a series of papers. Some of them suggested the idea to decrease the amount of smoothing (so called temperature) while getting closer to the optimum. However, no theoretical substantiation was provided. We propose an adaptive smoothing diminishing algorithm based on the duality gap between relaxed primal and dual objectives and demonstrate the efficiency of our approach with a smoothed version of Sequential Tree-Reweighted Message Passing (TRW-S) algorithm. The strategy is applicable to other algorithms as well, avoids adhoc tuning of the smoothing during iterations, and provably guarantees convergence to the optimum.
Ageing Technologically: Exploring the Motivating Operations of Technology Use by Older Adults

Statistics from the 2011 UK Census revealed that one sixth of the population were over the age of 65, which is the highest recorded ratio in any census history. Although there are discrepancies in the physical, mental and social wellbeing of the older adult population, huge strains have been placed upon the National Health Service, care system and subject population. Previous scholarship has revealed that technology use in various formats can reduce these pressures, however, published work on older adults and technology often focusses on attitudes and intentions rather than motivations of actual use. This thesis addresses this gap in the literature by examining the Motivating Operations (MOs) on post-purchase technology use of older adults. By adopting a radical behaviourist perspective, the present research attempts to introduce the Applied Behaviour Analysis (ABA) term, Motivating Operation, to consumer behaviour by incorporating the proposed MOs into the already established Behavioural Perspective Model (BPM). This approach encourages the measurement of actual technology use as an operant behaviour alongside the MOs, as independent variables, impacting upon the rate-of-response. Consequently, a longitudinal quantitative and qualitative empirical strategy has been devised to produce a rich and complex set of data to explain older adult technology use. Overall, by using principles of behaviourism to interpret the technology use of older adults within a post-purchase environment, this thesis intends to break the dominant trend within technology acceptance and adoption literature of relying on either the Technology Acceptance Model (TAM) or Diffusion of Innovation (DIT) to explain behaviours related to technology use. Alternatively, it produces an imaginative but logical analysis of the subject behaviour, which is not in contention with previous models but intends to enhance and expand the consumer behaviour, technology acceptance and adoption literature.
Obstacle-avoiding rectilinear Steiner tree construction

In todaypsilas VLSI designs, there can be many blockages in a routing region. The obstacle-avoiding rectilinear Steiner minimum tree (OARSMT) problem has become an important problem in the physical design stage of VLSI circuits. This problem has attracted a lot of attentions in research and several approaches have been proposed to solve this problem effectively. In this paper, we will present a heuristic maze routing based approach to solve this OARSMT problem. It is commonly believed that maze routing based approaches can only handle small scale problems and there is a lack of an effective multi-terminal variant to handle multi-pin nets in practice. We will show in this paper that maze routing based approaches can also handle large scale OARSMT problems effectively. Our approach is based on the searching process as in maze routing and can handle multi-pin nets very well in both solution quality, running time and memory space usage. We have compared our results with those of the previous works and can show that we can out-perform the best previous results on this problem [15] by giving an OARSMT with 2.01% less wire length on average and can make a 27.04% improvement in wire length in comparison with a lower bound of the optimal solution on average, while the running times are all very short and comparable to those in [15]. Besides, due to the flexibility of maze routing, we can handle different kinds of obstacles with different convex or concave rectilinear shapes directly without a need to partition each blockage into a set of rectangular sub-blockages, which will increase the size of the problem.
Beyond cognition and affect: sensing the unconscious

In the past decade, research on human–computer interaction has embraced psychophysiological user interfaces that enhance awareness of computers about conscious cognitive and affective states of users and increase their adaptive capabilities. Still, human experience is not limited to the levels of cognition and affect but extends further into the realm of universal instincts and innate behaviours that form the collective unconscious. Patterns of instinctual traits shape archetypes that represent images of the unconscious. This study investigated whether seven various archetypal experiences of users lead to recognisable patterns of physiological responses. More specifically, the potential of predicting the archetypal experiences by a computer from physiological data collected with wearable sensors was evaluated. The subjects were stimulated to feel the archetypal experiences and conscious emotions by means of film clips. The physiological data included measurements of cardiovascular and electrodermal activities. Statistical analysis indicated a significant relationship between the archetypes portrayed in the videos and the physiological responses. Data mining methods enabled us to create between-subject prediction models that were capable of classifying four archetypes with an accuracy of up to 57.1%. Further analysis suggested that classification performance could be improved up to 70.3% in the case of seven archetypes by using within-subject models.
Molecular Systems Biology Peer Review Process File Constant Rate of P53 Tetramerization in Response to Dna Damage Controls the P53 Response Transaction Report

(Note: With the exception of the correction of typographical or spelling errors that could be a source of ambiguity, letters and reports are not edited. The original formatting of letters and referee reports may not be reflected in this compilation.) Thank you again for submitting your work to Molecular Systems Biology. We have now heard back from the three referees who agreed to evaluate your manuscript. As you will see from the reports below, the referees acknowledge that you address a potentially interesting topic. However, they raise a series of concerns, which should be carefully addressed in a revision of the manuscript. Overall, the referees think that as it stands, the study seems somewhat preliminary and point out that further experiments are required to robustly support the main conclusions. Without repeating all the points listed below, among the more fundamental issues are the following:-Additional experimental evidence is required to demonstrate more convincingly that only p53 tetramerization leads to the formation of active YFP, while p53 dimerization does not. -The potential effect of the split YFP in driving tetramerization needs to be excluded (point #2 of reviewer #2). -The role of ARC in controlling the tetramerization of p53 should be examined in further detail. Reviewer #3 includes constructive suggestions in this regard. If you feel you can satisfactorily deal with these points and those listed by the referees, you may wish to submit a revised version of your manuscript. Please attach a covering letter giving details of the way in which you have handled each of the points raised by the referees. A revised manuscript will be once again subject to review and you probably understand that we can give you no guarantee at this stage that the eventual outcome will be favorable.
The Mediating Effect of Self-Control on Parenting and Delinquency: A Gendered Approach With a Multinational Sample

This study aims to clarify the relationships between parenting techniques, low self-control, and juvenile delinquency in Gottfredson and Hirschi’s general theory of crime while controlling for alternative explanations of delinquency. We relied on a sample of 35,511 adolescent students from 31 countries from the International Self-Report Delinquency 2 Study. Results indicate that parenting exhibits a direct effect on adolescents’ violence perpetration and property offending, and that while self-control weakens the strength of this relationship, it fails to fully mediate it. Males reported lower levels of self-control, exposure to poorer parenting techniques, and higher rates of violence perpetration and property offending. The relationship between parenting, self-control, and juvenile delinquency was similar for females and males. These results provide evidence that parenting has important implications for adolescents’ involvement in delinquency above and beyond its influence on their level of self-control.
Mode of Action of Gabapentin in Chronic Neuropathic Pain Syndromes

Summary Gabapentin (GBP, CAS 60142-96-3) has anticonvulsant and antinociceptive properties; the latter relate especially to chronic neuropathic pain. The mode of action of GBP, possibly different in epilepsy and chronic pain syndromes, is only poorly understood. This minireview s aimed at compiling the different mechanisms by which GBP may diminish the nociceptive transmission in the dorsal horn of the spinal cord.
Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway

Summary The inhibition of phosphatidic acid phosphatase (PAP) activity by propanolol indicates that diacylglycerol (DAG) is required for the formation of transport carriers at the Golgi and for retrograde trafficking to the ER. Here we report that the PAP2 family member lipid phosphate phosphatase 3 (LPP3, also known as PAP2b) localizes in compartments of the secretory pathway from ER export sites to the Golgi complex. The depletion of human LPP3: (i) reduces the number of tubules generated from the ER–Golgi intermediate compartment and the Golgi, with those formed from the Golgi being longer in LPP3-silenced cells than in control cells; (ii) impairs the Rab6-dependent retrograde transport of Shiga toxin subunit B from the Golgi to the ER, but not the anterograde transport of VSV-G or ssDsRed; and (iii) induces a high accumulation of Golgi-associated membrane buds. LPP3 depletion also reduces levels of de novo synthesized DAG and the Golgi-associated DAG contents. Remarkably, overexpression of a catalytically inactive form of LPP3 mimics the effects of LPP3 knockdown on Rab6-dependent retrograde transport. We conclude that LPP3 participates in the formation of retrograde transport carriers at the ER–Golgi interface, where it transitorily cycles, and during its route to the plasma membrane.
Diagnostic accuracy of rim and segmental MRI enhancement of colorectal hepatic metastasis after administration of mangafodipir trisodium.

OBJECTIVE The purpose of this study was to determine the diagnostic accuracy of rim and segmental MRI enhancement of hepatic metastasis of colorectal cancer after administration of mangafodipir trisodium (MnDPDP). SUBJECTS AND METHODS Sixty-one patients with a potentially resectable hepatic metastasis of colorectal cancer consecutively underwent breath-hold T1-weighted MRI in the axial and coronal planes 30 minutes and 24 hours after administration of MnDPDP. For each lesion, the presence or absence of rim enhancement and segmental enhancement 30 minutes and 24 hours after contrast administration was recorded. These features were evaluated separately for lesions 10 mm in diameter or larger and lesions smaller than 10 mm. The nature of each lesion was determined at histopathologic examination (n = 29) and on follow-up imaging (n = 32). RESULTS Two hundred thirty lesions were identified at MRI: 210 lesions were metastatic, and 20 were benign. Rim enhancement was observed around 22 of 210 (10%) of the metastatic lesions at 30 minutes and 199 of 210 (95%) of metastatic lesions at 24 hours. Rim enhancement at 24 hours had 94.8% (95% CI, 91.8-97.8%) sensitivity, 90.0% (68.3-98.8%) specificity, 99.0% (97.6-100%) positive predictive value, 62.1% (42.3-79.3%) negative predictive value, and 94.3% (91.4-97.3%) diagnostic accuracy for metastasis. Segmental enhancement was infrequently seen (34/210; 16%) at 24 hours but had 100% (89.7-100%) positive predictive value for metastasis. CONCLUSION Rim and segmental enhancement at MRI 24 hours after MnDPDP administration enabled accurate characterization of hepatic colorectal metastasis. These features may aid in preoperative mapping of hepatic tumor burden and disease distribution in patients with colorectal cancer.