Miracle-dz/UniFAR-FTUs huggingface dataset:
Detecting Faint Galaxies by Stacking at 24 μm

We stack Spitzer 24 μm images for ~7000 galaxies with 0.1 ≤ z < 1 in the Chandra Deep Field South to probe the thermal dust emission in low-luminosity galaxies over this redshift range. Through stacking, we can detect mean 24 μm fluxes that are more than an order of magnitude below the individual detection limit. We find that the correlations for low- and moderate-luminosity galaxies between the average LIR/LUV and rest-frame B-band luminosity, and between the star formation rate (SFR) and LIR/LUV, are similar to those in the local universe. This verifies that oft-used assumption in deep UV/optical surveys that the dust obscuration-SFR relation for galaxies with SFR ≤ 20 M☉ yr-1 varies little with epoch. We have used this relation to derive the cosmic IR luminosity density from z = 1 to z = 0.1. The results also demonstrate directly that little of the bolometric luminosity of the galaxy population arises from the faint end of the luminosity function, indicating a relatively flat faint-end slope of the IR luminosity function with a power-law index of 1.2 ± 0.3.
Self-control and need satisfaction in primetime: Television, social media, and friends can enhance regulatory resources via perceived autonomy and competence.

The relationship between self-control and media use is complicated. Loss of self-control capacity has been linked to generally higher levels of media use, which might represent self-regulatory failure, but could also be attempts at replenishing self-control. Indeed, self-determination theory proposes that satisfying intrinsic psychological needs (autonomy, competence, and relatedness), for example via media use, aids the recovery of self-control. In this 2-wave survey (N = 395), we examined the interplay of users’ self-control capacity and their perceived satisfaction of autonomy, competence, and relatedness needs via media use and alternative leisure activities. Satisfaction of intrinsic needs during leisure activities increased self-control capacity at the end of the evening. Feelings of autonomy and competence during TV and social media use, and competence during socializing, positively contributed to greater self-control. However, respondents with less self-control capacity before primetime experienced less intrinsic need satisfaction while engaged with TV, social media, reading, sports, and socializing, diminishing self-control at bedtime.
Creating safe atmospheres? Children’s experiences of grandparents’ affective and spatial responses to domestic violence

ABSTRACT While grandparenting literature has primarily discussed intergenerational relations in families with ‘normal’ everyday problems, such as childcare, it has largely neglected more troublesome issues, such as domestic violence. Based on interviews with ten children and teens, this article explores grandchildren’s experiences of how their grandparents have responded when they were being exposed to violence in the intermediate generation. These responses have affective-spatial aspects as the grandparents contributed to what we call ‘safe atmospheres’. Grandparents’ homes often provided a sense of safety, and grandparents at times contributed to a safe atmosphere in their grandchildren’s homes and helped to create safety and comfort in non-domestic places. Some grandparents, however, could be unsupportive and fail to contribute to safe atmospheres. Although physical space is important to create safety, in order to create a safe atmosphere, it has to correspond to a relational movement where grandparents side with their grandchildren.
Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants

Molecular modeling has been employed in the search for lead compounds of chemotherapy to fight cancer. In this study, pharmacophore models have been generated and validated for use in virtual screening protocols for eight known anticancer drug targets, including tyrosine kinase, protein kinase B β, cyclin-dependent kinase, protein farnesyltransferase, human protein kinase, glycogen synthase kinase, and indoleamine 2,3-dioxygenase 1. Pharmacophore models were validated through receiver operating characteristic and Güner–Henry scoring methods, indicating that several of the models generated could be useful for the identification of potential anticancer agents from natural product databases. The validated pharmacophore models were used as three-dimensional search queries for virtual screening of the newly developed AfroCancer database (~400 compounds from African medicinal plants), along with the Naturally Occurring Plant-based Anticancer Compound-Activity-Target dataset (comprising ~1,500 published naturally occurring plant-based compounds from around the world). Additionally, an in silico assessment of toxicity of the two datasets was carried out by the use of 88 toxicity end points predicted by the Lhasa’s expert knowledge-based system (Derek), showing that only an insignificant proportion of the promising anticancer agents would be likely showing high toxicity profiles. A diversity study of the two datasets, carried out using the analysis of principal components from the most important physicochemical properties often used to access drug-likeness of compound datasets, showed that the two datasets do not occupy the same chemical space.
Modeling Bottom-Up Visual Attention Using Dihedral Group D4

In this paper, first, we briefly describe the dihedral group D 4 that serves as the basis for calculating saliency in our proposed model. Second, our saliency model makes two major changes in a latest state-of-the-art model known as group-based asymmetry. First, based on the properties of the dihedral group D 4 , we simplify the asymmetry calculations associated with the measurement of saliency. This results is an algorithm that reduces the number of calculations by at least half that makes it the fastest among the six best algorithms used in this research article. Second, in order to maximize the information across different chromatic and multi-resolution features, the color image space is de-correlated. We evaluate our algorithm against 10 state-of-the-art saliency models. Our results show that by using optimal parameters for a given dataset, our proposed model can outperform the best saliency algorithm in the literature. However, as the differences among the (few) best saliency models are small, we would like to suggest that our proposed model is among the best and the fastest among the best. Finally, as a part of future work, we suggest that our proposed approach on saliency can be extended to include three-dimensional image data.
Feedback Inhibition of Ammonium Uptake by a Phospho-Dependent Allosteric Mechanism in Arabidopsis[W]

The acquisition of nutrients requires tight regulation to ensure optimal supply while preventing accumulation to toxic levels. Ammonium transporter/methylamine permease/rhesus (AMT/Mep/Rh) transporters are responsible for ammonium acquisition in bacteria, fungi, and plants. The ammonium transporter AMT1;1 from Arabidopsis thaliana uses a novel regulatory mechanism requiring the productive interaction between a trimer of subunits for function. Allosteric regulation is mediated by a cytosolic C-terminal trans-activation domain, which carries a conserved Thr (T460) in a critical position in the hinge region of the C terminus. When expressed in yeast, mutation of T460 leads to inactivation of the trimeric complex. This study shows that phosphorylation of T460 is triggered by ammonium in a time- and concentration-dependent manner. Neither Gln nor l-methionine sulfoximine–induced ammonium accumulation were effective in inducing phosphorylation, suggesting that roots use either the ammonium transporter itself or another extracellular sensor to measure ammonium concentrations in the rhizosphere. Phosphorylation of T460 in response to an increase in external ammonium correlates with inhibition of ammonium uptake into Arabidopsis roots. Thus, phosphorylation appears to function in a feedback loop restricting ammonium uptake. This novel autoregulatory mechanism is capable of tuning uptake capacity over a wide range of supply levels using an extracellular sensory system, potentially mediated by a transceptor (i.e., transporter and receptor).
Implementing evidence‐based practices in an emergency department: contradictions exposed when prioritising a flow culture

Background An emergency department is typically a place of high activity where practitioners care for unanticipated presentations, which yields a flow culture so that actions that secure available beds are prioritised by the practitioners. Objectives How does the flow culture in an emergency department influence nurses’ use of a research‐based clinical guideline and a nutrition screening routine. Methods Ethnographic fieldwork was carried out over three months. The first author followed nurses, medical secretaries and doctors in the emergency department. Data were also collected by means of semi‐structured interviews. An activity system analysis, as described in the Cultural Historical Activity Theory, was conducted to identify various contradictions that could exist between different parts of the activity system. Results The main contradiction identified was that guidelines and screening routines provided a flow stop. Four associated contradictions were identified: insufficient time to implement guidelines; guilty conscience due to perceived nonadherence to evidence‐based practices; newcomers having different priorities; and conflicting views of what constituted being a professional. Conclusion We found that research‐supported guidelines and screening routines were not used if they were perceived to stop the patient flow, suggesting that the practice was not fully evidence based.
Local circuit neurons of macaque monkey striate cortex: II. Neurons of laminae 5B and 6

This study investigates the intrinsic organization of axons and dendrites of aspinous, local circuit neurons of the macaque monkey visual striate cortex. These investigations use Golgi Rapid preparations of cortical tissue from monkeys aged 3 weeks postnatal to adult. We have earlier (Lund, '87) described local circuit neurons found within laminae 5A and 4C; this present account is of neurons found in the infragranular laminae 5B and 6. Since the majority of such neurons are GABAergic and therefore believed to be inhibitory, their role in laminae 5B and 6, the principal sources of efferent projections to subcortical regions, is of considerable importance. We find laminae 5B and 6 to have in common at least one general class of local circuit neuron–the “basket” neuron. However, a major difference is seen in the axonal projections to the superficial layers made by these and other local circuit neurons in the two laminae; lamina 5B has local circuit neurons with principal rising axon projections to lamina 2/3A, areas whereas lamina 6 has local circuit neurons with principal rising axon projections to divisions of 4C, 4A, and 3B. These local circuit neuron axon projections mimic the different patterns of apical dendritic and recurrent axon projections of pyramidal neurons lying within laminae 5B and 6, which are linked together by both dendritic and axonal arbors of local circuit neurons in their neuropils extending between the two laminae. The border zone between 5B and 6 is a specialized region with its own variety of horizontally oriented local circuit neurons, and it also serves as a special focus for pericellular axon arrays from a particular variety of local circuit neuron lying within lamina 6. These pericellular axon “baskets” surround the somata and initial dendritic segments of the largest pyramidal neurons of layer 6, which are known to project both to cortical area MT (V5) and to the superior colliculus (Fries et al., '85). Many of the local circuit neurons of layer 5B send axon trunks into the white matter, and we therefore, suspect them of providing efferent projections. The axons of lamina 6 local circuit neurons have not been found to make such clear‐cut contributions to the white matter.
On orbit‐reflexive operators

Let T be a bounded linear Banach space operator such that ∑n=1∞1/||Tn||<∞ . Then T is orbit‐reflexive. In particular, every Banach space operator with a spectral radius different from 1 is orbit‐reflexive. Better estimates are obtained for operators in Hilbert spaces. We also present a simple example of a nonorbit‐reflexive Hilbert space operator and an example of a reflexive but nonorbit‐reflexive operator (acting on ℓ1).
Representations of black people in the Slovenian translations of Karl May’s novels: A case study

The article discusses how black people were portrayed in the Slovenian translations of the novels Winnetou, Old Surehand and Der Schatz im Silbersee, which have all been translated into Slovenian several times; the analysis thus reveals how translation strategies have changed over the decades. The comparison shows that the strategies in translations published in the 1930s were somewhat different from those in the post-World War II period, when the Slovenian territory was part of socialist Yugoslavia; because of the unacceptability of racist views during the socialist period, some racist passages of the original texts were censored in the translations. A substantial amount of neutralization of pejorative racial terminology occurred in both pre- and post-War translations, and translators in both eras also used similar strategies for translating black people’s sociolect. The interventions in the translations have somewhat affected how the translated works can be interpreted.
Two responses of a uniformly stratified flow over a sloping bottom to a spatially varying downwelling favorable wind

The work was motivated by studies of Austin and Lentz (2002) and Pedlosky (2007). The above mentioned works considered two different responses of the stratified flow to a downwelling favorable wind forcing. The first study investigated a time dependent flow with a formation of a constantly expanding relatively well mixed region near the shore and the second considered a steady flow that arises when an offshore varying wind is applied. In my thesis I use ROMS to determine which type of response will take place based on the wind amplitude near the coast. It was demonstrated that if the value of the wind is much smaller than the critical value (determined by the stratification, the rotation rate and the horizontal diffusivity) then the flow is steady (the bbl case) and similar to the one investigated by Pedlosky. If the wind is of the order, or larger than, the critical value then the response is time dependent (the pool case) and similar to the one described by Austin and Lentz. The resulting flow structure of each response was also investigated. I examined the sensitivity of the bbl response to variations in the background vertical diffusivity, the initial stratification and the bottom slope. It was shown that a higher background vertical diffusivity, a higher stratification and a shallower bottom slope correspond to thinner (vertically) and narrower (horizontally) bbl. For the pool case the time dependent structure was also examined, using a number of idealized models. It was shown that the rate of the pool region expansion is a complex function of the local wind stress amplitude and the local depth. Thesis Supervisor: Joseph Pedlosky Title: Scientist Emeritus
Situational Judgment Tests and Transformational Leadership: An Examination of the Decisions, Leadership, and Experience in Undergraduate Leadership Development

Leadership, and Experience in Undergraduate Leadership Development Abstract We examined a large multi-year undergraduate leadership development program (LDP) across seven universities and used an integrated framework of transformational leadership and situational judgment tests (SJTs) during a critical and formative period of leadership development. This study was the first to show a significant relationship between experience and transformational leadership style in students in an undergraduate LDP using SJTs. The results showed that greater experience was positively related to increased transformational leadership style and that high overall decision scores were indicated in all groups of students with varying leadership styles and varying experience levels and decision abilities. The study findings and implications are discussed, along with recommendations for leadership educators to develop decision quality in LDPs.
Contract Performance in Offshore Systems Development: Role of Control Mechanisms

Although control theory has often been invoked to explain the coordination between client and vendor for information systems development (ISD), insights into its moderating effects for explicating ISD contract performance, especially in the offshore context, is rather limited. Such insights would enable better understanding of variables that have complementary or substitutive effects on performance. Further, the control literature talks about different control modes (e.g., formal and informal control modes classified as behavior, outcome, clan, and self-control modes) without adequately distinguishing among the different control mechanisms enacting each of the control modes. In this research, by explicitly classifying the distinctions that exist within each of the control modes, we uncover the key role played by mechanistic governance in outsourced ISD. Grounding our arguments in the information requirement for performance evaluation, the study theorizes the moderating influence of mechanistic governance on the relationships of contract specificity and relational governance with ISD quality and cost performance. We test the theorized model in a field study comprising 160 offshore ISD projects executed by Indian vendors. Our results establish the significant complementary role of mechanistic governance on the relationships of contract specificity with both cost and quality performance variables. Further, mechanistic governance substitutes the impact of relational governance on cost performance. Thus, the study theoretically as well as empirically establishes the need for conceptualizing mechanistic governance as a viable and significant governance mechanism for offshore ISD contracts. The study also teases out the distinctions between the two prime contract types in vogue for managing offshore ISD contracts, namely, fixed price and time and materials contracts. The study thus contributes not only to control theory but also to the stream of literature examining offshore ISD contracts. Further, the study provides insights to managers on having well-specified contracts and acknowledging the role of mechanistic governance for better performance.
Optimised operating range of modular multilevel converters for AC/AC conversion with failed modules

AC/AC modular multilevel topologies, such as Modular Multilevel Matrix Converter, Hexverter, and Modular Multilevel Converter in back-to-back configuration can be still operated when one or more modules failed, even if no extra module was added for redundancy. This paper proposes two novel approaches for the operation of these converter topologies with a reduced number of modules in wind energy systems. For each topology, the remaining operating areas for different scenarios of failed modules are presented, and the influence on the annual energy production is discussed.
Venture‐Capital Syndication: Improved Venture Selection vs. The Value‐Added Hypothesis

Syndication arises when venture capitalists jointly invest in projects. We model and test two possible reasons for syndication: project selection, as an additional venture capitalist provides an informative second opinion; and complementary management skills of additional venture capitalists. The central question is whether venture capitalists are engaged primarily in selection or in managerial value added. These alternatives imply contrasting predictions about comparative returns to syndicated and standalone investments. Our empirical analysis, using Canadian data, finds that syndicated investments have higher returns, favoring the value-added interpretation. We also discuss risk sharing and project scale as possible reasons for syndication. Copyright (c) 2002 Massachusetts Institute of Technology.
Serum Neuregulin-1β as a Biomarker of Cardiovascular Fitness

PURPOSE: Neuregulins (NRG) are growth factors that bind to receptors of the erbB family, and are known to mediate a number of processes involved in diverse tissues. Neuregulin-1beta is expressed in skeletal muscle and is activated by exercise. We hypothesized that NRG-1beta might circulate in the bloodstream and increase as a consequence of physical activity. A study was conducted in healthy subjects to determine if NRG-1beta is immunodetectable in human serum, and if so whether levels relate acutely or chronically to exercise. METHODS: Nine healthy men underwent three bouts of exercise of varying degrees of intensity on a bicycle ergometer over a period of three weeks. Cardio-respiratory fitness was determined by measurement of maximal oxygen uptake (VO(2)max). Serum was sampled prior to and immediately after each session (up to 30 minutes post) and serum NRG-1beta was quantified utilizing an indirect sandwich ELISA assay developed in our lab. RESULTS: Across subjects, mean serum NRG-1beta levels ranged from 32 ng/mL to 473 ng/mL. Individual subjects showed relatively stable levels during the study period that did not change acutely after exercise. Serum NRG-1beta demonstrated a positive correlation with VO(2)max (r2=0.49, p =.044). CONCLUSIONS: These preliminary observations suggest that at least in healthy men, serum NRG-1beta is an indicator of cardio-respiratory fitness and does not change acutely with exercise.
Distinct, parallel pathways link the medial mammillary bodies to the anterior thalamus in macaque monkeys

Mammillary body neurons projecting to the thalamus were identified by injecting retrograde tracers into the medial thalamus of macaque monkeys. The source of the thalamic projections from the medial mammillary nucleus showed strikingly different patterns of organization depending on the site of the injection within the two anterior thalamic nuclei, anterior medialis and anterior ventralis. These data reveal at least two distinct modes by which the primate medial mammillary bodies can regulate anterior thalamic function. Projections to the thalamic nucleus anterior medialis arise mainly from the pars lateralis of the medial mammillary nucleus. A particularly dense source is the dorsal cap in the posterior half of the pars lateralis, a subregion that has not previously been distinguished. In contrast, neurons spread evenly across the medial mammillary nucleus gave rise to projections more laterally in the anterior thalamic nuclei. A third pattern of medial mammillary neurons appeared to provide the source of projections to the rostral midline thalamic nuclei. In contrast, the labeled cells in the lateral mammillary nucleus were evenly spread across that nucleus, irrespective of injection site. In addition to the established projection to anterior dorsalis, the lateral mammillary nucleus appears to project lightly to a number of other thalamic nuclei, including lateralis dorsalis, anterior medialis, anterior ventralis, and the rostral midline nuclei, e.g. nucleus reuniens. These anatomical findings not only reveal novel ways of grouping the neurons within the medial mammillary nucleus, but also indicate that the mammillothalamic connections support cognition in multiple ways.