Miracle-dz/UniFAR-FTUs huggingface dataset:
Importance Destination Loyalty: The Case Monumen Tugu Pahlawan in Surabaya, East Java

The focus of the research is to examine and analyze the factors of the importance of destination loyalty in historical places. It can be said that historical places have their uniqueness or characteristics as an identity and value that must be preserved. Method: This research uses a quantitative method where SEM-PLS is used to test and analyze the collected data in the form of respondents' answers in the questionnaire. The number of respondents was 210, who had characteristics of educational background, age, gender, and social media used so that this could describe the level of respondents' understanding of knowledge and love of historical places. Results showed that the three antecedents are tourist satisfaction, patriotism, and gender, which motivate someone to intend and re-visit a monument and influence destination loyalty. It can be clearly illustrated that respondents have a strong emotional bond with the historical value of destination loyalty. Novelty: gender has an important meaning and can be a moderating variable. Originality: historical value in the form of the results of the struggle of Surabaya youth against the colonialists, which is then realized in a destination.
RPE-normalized RNFL attenuation coefficient maps derived from volumetric OCT imaging for glaucoma assessment.

PURPOSE We present spatial retinal nerve fiber layer (RNFL) attenuation coefficient maps for healthy and glaucomatous eyes based on optical coherence tomography (OCT) measurements. Quantitative analyses of differences between healthy and glaucomatous eyes were performed. METHODS Peripapillary volumetric images of 10 healthy and 8 glaucomatous eyes were acquired by a Spectralis OCT system. Per A-line, the attenuation coefficient of the RNFL was determined based on a method that uses the retinal pigment epithelium as a reference layer. The attenuation coefficient describes the attenuation of light in tissue due to scattering and absorption. En-face maps were constructed and visually inspected. Differences between healthy and glaucomatous eyes were analyzed (Mann-Whitney U test), both globally (average values) and spatially (concentric and per segment). RESULTS RNFL attenuation coefficient maps of healthy eyes showed relatively high and uniform values. For glaucomatous eyes, the attenuation coefficients were much lower and showed local defects. Normal and glaucomatous average RNFL attenuation coefficients were highly significantly different (P < 0.0001) and fully separable. The RNFL attenuation coefficient decreased with increasing optic nerve head distance for both groups, with highly significant differences for all distances (P < 0.001). The angular dependency showed high superio- and inferiotemporal and low nasal values, with most significant differences superio- and inferiotemporally. CONCLUSIONS Maps of RNFL attenuation coefficients provide a novel way of assessing the health of the RNFL and are relatively insensitive to imaging artifacts affecting signal intensity. The highly significant difference between normal and glaucomatous eyes suggests using RNFL attenuation coefficient maps as a new clinical tool for diagnosing and monitoring glaucoma.
Textbook of Tinnitus

The Spectrum of Neuro-AIDS Disorders presents, in 36 chapters, the relevant basic knowledge on human immunodeficiency virus (HIV) infection and the nervous system. The editors succeeded in acquiring the services of very well-known specialists in the field for every chapter, guaranteeing a deep understanding of the topics with respect to clinical problems and research results. For physicians who want comprehensive information, as well as for students and informed laymen, the book is easily readable. The prose is easily understandable, although on a high scientific level. The quality of the figures, tables, and illustrations is very good, and they all help to underline and explain the text. Another advantage is that the book addresses aspects that have rarely been the focus of interest (eg, neuro-AIDS disorders, gender and antiretroviral combination treatment, and neuro-AIDS disorders and ethnicity). The main sections 1 through 6 describe every topic of interest in the field, such as disorders primarily provoked by HIV infection, pathophysiological aspects, neuroimaging, comorbidities, neuro-AIDS disorders in special populations, and special health care issues. Everybody who has a diagnostic or therapeutic problem regarding neuro-AIDS disorders in clinical practice will find it helpful to read the corresponding chapter in the book. Additionally, the references in every chapter are excellent, so much so that the reader has the opportunity to broaden his or her knowledge. Thus, the book is highly useful and should be in every university library. Prose Illustrations Science Usefulness
Dental pulp stem cells and their characterization.

AIMS Our aims were to isolate dental pulp stem cells, to cultivate them in various media and to investigate their basic biological properties and phenotype. METHODS 16 lines of dental pulp stem cells (DPSCs) were isolated from an impacted third molar. After enzymatic dissociation of dental pulp, DPSCs were cultivated in modified cultivation media for mesenchymal adult progenitor cells containing 2 % or 10 % fetal calf serum (FCS), or in modified 2 % FCS cultivation media supplemented with ITS. Cell viability and other biological properties were examined periodically using a Vi-Cell analyzer and Z2-Counter. DNA analysis and phenotyping were done using flow cytometry. RESULTS We were able to cultivate DPSCs in all tested cultivation media over 40 population doublings. Our results showed that DPSCs cultivated in medium supplemented with ITS had shorter average population doubling time (24.5, 15.55-35.12 hours) than DPSCs cultivated in 2 % FCS (55.43, 21.57-187.14 hours) or 10 % FCS (42.56, 11.86 - 101.3 hours). Cell diameter was not affected and varied from 15 to 16 microm. DPSCs viability in the 9(th) passage was over 90 %. Our phenotypical analysis was highly positivity for CD29, CD44, CD90 and HLA I, and negative for CD34, CD45, CD71, HLA II. DPSC lines cultivated in all media showed no signs of degeneration or spontaneous differentiation during the expansion process. CONCLUSIONS We showed that ITS supplement in the cultivation media greatly increased the proliferative activity of DPSCs. Other DPSC biological properties and phenotype were not affected.
Videogames and open feedback systems to enhance probabilistic reasoning and engagement

This study analyzed the relationship between probabilistic reasoning, feedback type, and engagement across four sessions of an DGBL educational practice with a feedback system. Results show that engagement and probabilistic reasoning varied longitudinally during the intervention. In addition, the teacher’s feedback was found to be of an open-ended type. Significant correlations were established between probabilistic reasoning and feedback, as well as between engagement and probabilistic reasoning in one of the sessions. Implications for teaching and designing DGBL sequences are presented.
Stress distribution on dentin-cement-post interface varying root canal and glass fiber post diameters. A three-dimensional finite element analysis based on micro-CT data

Objective The aim of the present study was to analyze the influence of root canal and glass fiber post diameters on the biomechanical behavior of the dentin/cement/post interface of a root-filled tooth using 3D finite element analysis. Material and Methods Six models were built using micro-CT imaging data and SolidWorks 2007 software, varying the root canal (C) and the glass fiber post (P) diameters: C1P1-C=1 mm and P=1 mm; C2P1-C=2 mm and P=1 mm; C2P2-C=2 mm and P=2 mm; C3P1-C=3 mm and P=1 mm; C3P2-C=3 mm and P=2 mm; and C3P3-C=3 mm and P=3 mm. The numerical analysis was conducted with ANSYS Workbench 10.0. An oblique force (180 N at 45º) was applied to the palatal surface of the central incisor. The periodontal ligament surface was constrained on the three axes (x=y=z=0). Maximum principal stress (σmax) values were evaluated for the root dentin, cement layer, and glass fiber post. Results: The most evident stress was observed in the glass fiber post at C3P1 (323 MPa), and the maximum stress in the cement layer occurred at C1P1 (43.2 MPa). The stress on the root dentin was almost constant in all models with a peak in tension at C2P1 (64.5 MPa). Conclusion The greatest discrepancy between root canal and post diameters is favorable for stress concentration at the post surface. The dentin remaining after the various root canal preparations did not increase the stress levels on the root.
Chua's Singularities: Great MIRACLE in Circuit Theory

In the work [Chua, 1992], a deep intuition of its author gave rise to the choice of singularities corresponding to Chua's circuit. Therefore, it is the only one probably exhibiting three saddle points named Chua's singularities in this paper. One of the singularities is a saddle in forward time (dt > 0) of integration, whereas the other two are saddles in backward time (dt < 0) of integration. In the following, the term Chua's Chaos denotes chaos related to Chua's singularities. These singularities are the source of all special surfaces that are the subject of this contribution. We named the surface to which all other surfaces are bound as the Double-Arm Stable Manifold (DASM). The beauty and multifunctionality of this surface represents the unfathomable Intelligence in the sense of [Tolle, 2003]. The presence of the DASM in the state space is a sufficient condition for the generation of Chua's chaos or corresponding periodic windows. Since Chua's singularities are not limited by circuit morphology or the order of state equations, the research on Chua's chaos seems to be still very promising.
Trajectory and Predictors of Alliance in Cognitive Behavioral Therapy for Youth Anxiety

Multilevel growth analysis was used to establish the shape of change (mean growth trajectory) for youth- and therapist-rated alliance in cognitive behavioral therapy (CBT) for anxious youth and to identify between-youth predictors of alliance trajectory. Youth (N = 69; ages 7–17; 52.2% female) and their parents participated in an empirically supported CBT protocol. Therapists rated alliance each session and youth every four sessions. Data were fit to four growth models: linear, quadratic, a dual slope, and a novel “alliance rupture” model. Two-level models were estimated to examine the effect of youth age, sex, pretreatment symptom severity, diagnostic comorbidity, early treatment factors (use of Selective Serotonin Reuptake Inhibitors), and coping styles (engagement, disengagement, and involuntary coping). A dual slope model fit therapist data best, whereas youth data did not evidence systematic growth. Two-level growth models identified that pretreatment anxiety severity predicted higher initial alliance levels. Depressive symptoms predicted less linear growth and engagement coping predicted greater growth during exposure sessions. No variables predicted preexposure growth. In the therapist model, 22% of initial alliance, 50% of preexposure growth, and 75% of postexposure growth were accounted for by between youth variables (mood disorder, anxiety and depression symptoms, engagement and involuntary coping). Therapist-reported alliance ratings may grow over the course of manual-based CBT, even during exposure-focused sessions. Pretreatment youth factors and coping style may influence the absolute value and linear trajectory of alliance during CBT. Findings about alliance-influencing factors can help set expectations for, and enhance training in, empirically supported treatments.
Evaluating the performance of the lee-carter method for forecasting mortality

Lee and Carter (LC) published a new statistical method for forecasting mortality in 1992. This paper examines its actual and hypothetical forecast errors, and compares them with Social Security forecast errors. Hypothetical historical projections suggest that LC tended to underproject gains, but by less than did Social Security. True e0 was within the ex ante 95% probability interval 97% of the time overall, but intervals were too broad up to 40 years and too narrow after 50 years. Projections to 1998 made after 1945 always contain errors of less than two years. Hypothetical projections for France, Sweden, Japan, and Canada would have done well. Changing age patterns of mortality decline over the century pose problems for the method.
Visual dysfunction among styrene-exposed workers.

OBJECTIVES The present study was undertaken to examine the relation between visual functions and occupational exposure to styrene. METHODS A total of 128 workers (85% of the total population), from three glass-reinforced plastics plants in Canada, agreed to participate in the study. Environmental and biological measures were made on the day(s) prior to the assessment of near visual acuity (National Optical Visual Chart), chromatic discrimination (Lanthony D-15 desaturated panel), and near contrast sensitivity (Vistech 6000). The analyses were performed on 81 workers with near visual acuity of at least 1 min of arc at 0.5 m. RESULTS The subjects were relatively young [29 (SD 8) years], with little seniority [5 (SD 4) years]. Styrene exposure for 8 h ranged from 6 to 937 (first quartile 21 mg.m-3, third quartile 303 mg.m-3), depending on the job site. The end-shift concentrations of urinary mandelic acid ranged from nondetectable to 1.90 mmol.mmol creatinine-1. Significant positive relations were found between the internal and external styrene exposure measurements and color vision loss adjusted for age, alcohol consumption, and seniority in a multiple regression analysis. The multiple regression analysis is also showed that the end-shift concentration of urinary mandelic acid was inversely related to contrast sensitivity at 6 and 12 cycles.degree-1. Logistic multiple regression models indicated that the end-shift concentration of urinary mandelic acid was related to the prevalences of blurred vision, tearing, and eye irritation. CONCLUSIONS These findings suggest that there is a positive relation between styrene exposure and early color and contrast vision dysfunction.
Surgical treatment of pituitary neuroendocrine tumors with coexisting intracranial lesions: A case series and review of the literature

Pituitary neuroendocrine tumors (PitNETs) are a diverse group of benign neoplasms that account for a significant proportion of intracranial tumors (13%). The coexistence of PitNET with other intracranial lesions, such as meningiomas and intracranial aneurysms, has been constantly reported in the literature; yet, the pathophysiological mechanisms remain unknown, and the appropriate management is controversial. This study aims to describe the clinical characteristics, surgical treatment, and outcomes of patients with PitNET with coexisting intracranial lesions in a single healthcare center. A retrospective analysis was conducted on 12 patients who underwent surgical treatment for PitNET and another intracranial lesion at our single tertiary referral center over 15 years from January 2008 to May 2023. Among these coexisting lesions, aneurysms were the most commonly found (41.67%), followed by meningiomas (33.33%). Surgical intervention for both lesions was performed in a single-stage procedure for most cases (75%), employing transcranial, endoscopic endonasal, and combined approaches. We found low preoperative Karnofsky Performance Scale scores in three patients, with significant differences in functional outcomes. These findings contribute to the limited knowledge about PitNET coexisting with other intracranial lesions and emphasize the importance of patient-tailored, multidisciplinary management in these unusual scenarios.
Atrial Infarction of the Heart

Six cases of atrial infarction associated with ventricular infarction are presented. All cases were diagnosed during life and were confirmed by autopsy. A clinical diagnosis of atrial infarction should be suspected in patients with ventricular myocardial infarction having any form of atrial arrhythmia. Frequent electrocardiograms should be obtained, especially if sinus rhythm has just been re-established after episodes of supraventricular tachycardia or atrial fibrillation. The major electrocardiographic criteria for the diagnosis of atrial infarction are as follows: elevation of the P-Ta segment of over 0.5 mm. in V5; and V6 with reciprocal depression of the same segment in V1 and V2; elevation of the P-Ta segment of over 0.5 mm. in lead I and its depression in leads II or III; depression of the P-Ta segment of more than 1.5 mm. in precordial leads and 1.2 mm. in leads I, II, and III in the presence of any form of atrial arrhythmia. The minor electrocardiographic criteria in making the diagnosis of atrial infarction are as follows: abnormal P waves: M-shaped, W-shaped, irregular or notched; depression of the P-Ta segment of small amplitude without elevation of this segment in other leads cannot be regarded by itself as positive evidence of atrial infarction. A diagnosis of atrial infarction can sometimes be made when the presence of ventricular myocardial infarction cannot be definitely established by electrocardiogram. The treatment of atrial infarction is similar to that of ventricular infarction. Attention should be directed to the control of atrial arrhythmias and to the prevention of mural thrombi.
pH-Dependent Conformational Changes in Proteins and Their Effect on Experimental pKas: The Case of Nitrophorin 4

The acid-base behavior of amino acids is an important subject of study due to their prominent role in enzyme catalysis, substrate binding and protein structure. Due to interactions with the protein environment, their pKas can be shifted from their solution values and, if a protein has two stable conformations, it is possible for a residue to have different “microscopic”, conformation-dependent pKa values. In those cases, interpretation of experimental measurements of the pKa is complicated by the coupling between pH, protonation state and protein conformation. We explored these issues using Nitrophorin 4 (NP4), a protein that releases NO in a pH sensitive manner. At pH 5.5 NP4 is in a closed conformation where NO is tightly bound, while at pH 7.5 Asp30 becomes deprotonated, causing the conformation to change to an open state from which NO can easily escape. Using constant pH molecular dynamics we found two distinct microscopic Asp30 pKas: 8.5 in the closed structure and 4.3 in the open structure. Using a four-state model, we then related the obtained microscopic values to the experimentally observed “apparent” pKa, obtaining a value of 6.5, in excellent agreement with experimental data. This value must be interpreted as the pH at which the closed to open population transition takes place. More generally, our results show that it is possible to relate microscopic structure dependent pKa values to experimentally observed ensemble dependent apparent pKas and that the insight gained in the relatively simple case of NP4 can be useful in several more complex cases involving a pH dependent transition, of great biochemical interest.
Comparison of Attachments in Real-World and Virtual-World Relationships

Objective: The burgeoning of online social networks raises questions about the quality and value of these interpersonal relationships. The present study employed an established measure of attachment security to compare the nature of individuals’ attachments in virtual-world relationships with those in real-world relationships and also examined the relative strength of attachments in the two types of relationships. Method: Participants were 125 volunteers recruited online who had established relationships in Second Life, a popular virtual world. Participants consented and completed all measures anonymously online. Results: The findings indicate that equally strong attachments are formed in virtual- and real-world relationships; there is modest correspondence in the quality of attachment in the two types of relationship; the strength of attachments in the virtual world is influenced by capacity to immerse oneself in fantasy; duration of the relationship is correlated with strength of attachment in both worlds; and emotional well-being relates to strength of attachment in real-world relationships and lower attachment anxiety in virtual-world relationships. Conclusions: The value of attachment relationships in virtual worlds calls for further investigation. Moreover, consistent with the growing employment of telemedicine, the potential for clinical interventions in virtual worlds merits consideration.
Parent perceptions of school-based support for students with traumatic brain injuries

Primary objective: To determine whether parents believe schools provided necessary support to their children who sustained traumatic brain injuries. Research design: Interview, to determine parent perceptions. Methods and procedure: Sixty-six primary caregivers of school-age children who experienced a TBI within the previous 2 years were interviewed regarding what types of special support were needed by and provided for their children during the 3 months immediately following school re-entry. They then rated how difficult it was to obtain support or services from the school and how satisfied they were with the support or services. Main outcomes and results: The majority of participants did not perceive the need for school-based services, even when the injury was severe. Almost all students whose parents perceived a need for an adjusted schedule were granted that accommodation, but few students received school-based counselling or behavioural support. Conclusions: Results indicated that participants perceived relatively few school-based supports, particularly given the actual academic, behavioural and social challenges experienced by children who have sustained a TBI. Schools and hospitals must take steps to ensure appropriate post-head injury support services.
The contribution of pharmaceutically active compounds from healthcare facilities to a receiving sewage treatment plant in Canada

Concentrations and percent loadings of pharmaceutically active compounds (PhACs) and other emerging contaminants released from healthcare facilities (2 hospitals and a long‐term care facility) to a sewage treatment plant (STP) in a large urban sewershed were evaluated. An additional hospital outside the sewershed was also monitored. Fourteen of the 24 steroids/hormones and 88 of the 117 PhACs and emerging contaminants were detected at least once. Commonly used substances, including cotinine, caffeine and its metabolite 1,7‐dimethylxanthine, ibuprofen and naproxen (analgesics), venlafaxine (antidepressant), and N,N‐diethyl‐meta‐toluamide (insect repellant), were detected in all samples at all sites. Concentrations detected in the large specialty hospital outside the sewershed were similar to those within the sewershed. Cytotoxic drugs (tamoxifen and cyclophosphamide) and x‐ray contrast media (iopamidol and diatrizoic acid) were infrequently detected in hospital effluents. Analysis for antibiotics indicated that azithromycin, clarithromycin, ciprofloxacin, erythromycin, ofloxacin, and sulfamethoxazole were consistently detected in hospital wastewaters, as was triclosan (antibacterial agent). Fifteen compounds individually contributed greater than 1% to the total PhAC and emerging contaminant load to the STP from the 2 hospitals in the sewershed, and 9 compounds in the STP effluent exceeded ecotoxicological criteria. The present survey demonstrates that point source discharges from healthcare facilities in this sewershed make a small contribution to the overall PhAC and emerging contaminant loading compared with the total concentrations entering the receiving STP. Environ Toxicol Chem 2016;35:850–862. © 2015 SETAC