Miracle-dz/UniFAR-FTUs huggingface dataset:
A low-complexity packet classification algorithm for multiple description video streaming over IEEE802.11E networks

The robust transmission of video sequences over wireless LANs presents several challenging problems concerning the presence of packet losses, delays, and bandwidth limitations. Their effect on the visual quality of the sequence reconstructed by the end user can be mitigated by adopting a wireless architecture that is able to support different levels of quality-of-service (QoS), like the IEEE 802.11e standard, and by compressing the video sequence to be transmitted using a robust source coder, like a multiple description coding (MDC) scheme. This paper presents a MDC-based video streaming architecture that tries to adaptively optimize the performance of both solutions by assigning the RTP video packets produced by the MDC encoder to the different QoS classes of IEEE 802.11e. Simulation results show that the performance is significantly improved with respect to a non-adaptive solution.
Non-response bias in estimates of HIV prevalence due to the mobility of absentees in national population-based surveys: a study of nine national surveys

Objectives: To measure the bias in national estimates of HIV prevalence in population-based surveys caused by mobility and refusal to test. Methods: Data from nine demographic and health surveys and AIDS indicator surveys were used. Non-responders were divided into three groups: (i) “refusals” who were interviewed but not tested; (ii) “refusals” who were present in the household but not interviewed or tested; and (iii) “absentees” who were absent from the household. Correction for HIV status was made for the non-responders using multiple imputation methods with logistic regression models based on a common set of household-level and individual-level sociodemographic and behavioural factors for those tested and stratified by mobility status. Results: The non-response groups were corrected to have higher risks of HIV than those who participated in the HIV tests, although these were only detected to be statistically significant in some of the countries. In Lesotho, the corrected prevalence for the absent household members was significantly higher than for those who were present in the household. However, the adjusted prevalences differed by less than a percentage point from the prevalences observed among those who were tested, so the overall effects of non-response on national estimates of HIV prevalence are minimal. Conclusions: The results indicate that the mobility of absentees does not substantially bias estimates of HIV prevalence from population-based surveys. None the less, if levels of non-response are high or if non-responders differ greatly from those who participate in HIV testing with respect to HIV status, non-response could still bias national estimates of HIV prevalence.
Analyzing Relatedness by Toponym Co‐Occurrences on Web Pages

This research proposes a method for capturing “relatedness between geographical entities” based on the co‐occurrences of their names on web pages. The basic assumption is that a higher count of co‐occurrences of two geographical places implies a stronger relatedness between them. The spatial structure of China at the provincial level is explored from the co‐occurrences of two provincial units in one document, extracted by a web information retrieval engine. Analysis on the co‐occurrences and topological distances between all pairs of provinces indicates that: (1) spatially close provinces generally have similar co‐occurrence patterns; (2) the frequency of co‐occurrences exhibits a power law distance decay effect with the exponent of 0.2; and (3) the co‐occurrence matrix can be used to capture the similarity/linkage between neighboring provinces and fed into a regionalization method to examine the spatial organization of China. The proposed method provides a promising approach to extracting valuable geographical information from massive web pages.
Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity

The present study was performed to gain insight into the role of p53 on the cytotoxicity of tubulin-binding agents (TBA) on cancer cells. Drug sensitivity, cell cycle distribution and drug-induced apoptosis were compared in 2 lines derived from the mammary adenocarcinoma MCF-7: the MN-1 cell line containing wild-type p53 (wt-p53) and the MDD2 line, containing a dominant negative variant of the p53 protein (mut-p53). The MDD2 cell line was significantly more resistant to the cytotoxic effects of vinblastine and paclitaxel than the MN1 cell line. MN1 cells, but not MDD2 cells, displayed wt-p53 protein accumulation as well as p21/WAF1 and cyclin G1 induction after exposure to TBA. Both cell lines arrested at G2/M after drug treatment. However exposure of MN1 cells to TBA resulted in a stronger variation in mitochondrial membrane potential, associated with cleavage of PARP, and more apoptosis, as measured by annexin V expression. After exposure to vinblastine, Raf 1 kinase activity was reduced in MDD2 cells but not in MN1 cells. Addition of flavopiridol to vinblastine- and paclitaxel-treated cells reversed the MDD2-resistant phenotype by inducing G1 cell cycle arrest and inhibiting endoreduplication. We conclude that the p53 status of cancer cells influences their sensitivity to TBA cytotoxicity. This effect is likely to involve differences in the apoptotic cascade. © 2001 Cancer Research Campaign http://www.bjcancer. com
A novel transcriptional element in circular DNA monomers of the duck hepatitis B virus

We report the presence of two elements, pet and net, that are required for proper transcription of the duck hepatitis B virus (DHBV). These regions were previously identified by using plasmid clones of the virus in transient expression assays (M. Huang and J. Summers, J. Virol. 68:1564-1572, 1994). In this study, we further analyzed these regions by using in vitro-synthesized circular DHBV DNA monomers to mimic the authentic transcriptional template. We observed that pet was required for pregenome transcription from circular viral monomers, and in the absence of pet-dependent transcription, expression of the viral envelope genes was increased. We found that deletion of net in circularized DNA monomers led to the production of abnormally long transcripts due to a failure to form 3' ends during transcription. In addition, we report the presence of a net-like region in the mammalian hepadnavirus woodchuck hepatitis virus. These results are consistent with a model that net is a region involved in transcription termination and that in DHBV, pet is required for transcription complexes to read through this region during the first pass through net.
Applications of self-regulated learning across diverse disciplines: A tribute to Barry J. Zimmerman.

Through its research-to-practice focus, this book honors the professional contributions of Professor Barry J. Zimmerman as illustrated by the recent selfregulation applications of a highly respected group of national and international scholars. This book will serve as a valuable resource for those interested in empowering and enabling learners to successfully manage and self-direct their lives, education, and careers. In particular, K-12 educators, college instructors, coaches, musicians, health care providers, and researchers will gain invaluable insight into the nature of self-regulation as well as how they can readily apply self-regulation principles into their teaching, instruction, or mentoring. Emergent trends in education and psychology circles, such as linking self-regulated learning assessment and interventions as well as the use of technology to enhance student learning and self-regulation, are additional themes addressed in the book. The kaleidoscope of self-regulation issues addressed in this book along with the wide range of promising intervention applications should also prove to be particularly appealing to graduate students as they pursue their future research activities and seek to optimize their individual growth and development.
Species and ecological diversity within the Cladosporium cladosporioides complex (Davidiellaceae, Capnodiales)

The genus Cladosporium is one of the largest genera of dematiaceous hyphomycetes, and is characterised by a coronate scar structure, conidia in acropetal chains and Davidiella teleomorphs. Based on morphology and DNA phylogeny, the species complexes of C. herbarum and C. sphaerospermum have been resolved, resulting in the elucidation of numerous new taxa. In the present study, more than 200 isolates belonging to the C. cladosporioides complex were examined and phylogenetically analysed on the basis of DNA sequences of the nuclear ribosomal RNA gene operon, including the internal transcribed spacer regions ITS1 and ITS2, the 5.8S nrDNA, as well as partial actin and translation elongation factor 1-α gene sequences. For the saprobic, widely distributed species Cladosporium cladosporioides, both a neotype and epitype are designated in order to specify a well established circumscription and concept of this species. Cladosporium tenuissimum and C. oxysporum, two saprobes abundant in the tropics, are epitypified and shown to be allied to, but distinct from C. cladosporioides. Twenty-two species are newly described on the basis of phylogenetic characters and cryptic morphological differences. The most important phenotypic characters for distinguishing species within the C. cladosporioides complex, which represents a monophyletic subclade within the genus, are shape, width, length, septation and surface ornamentation of conidia and conidiophores; length and branching patterns of conidial chains and hyphal shape, width and arrangement. Many of the treated species, e.g., C. acalyphae, C. angustisporum, C. australiense, C. basiinflatum, C. chalastosporoides, C. colocasiae, C. cucumerinum, C. exasperatum, C. exile, C. flabelliforme, C. gamsianum, and C. globisporum are currently known only from specific hosts, or have a restricted geographical distribution. A key to all species recognised within the C. cladosporioides complex is provided.
Projections of Incidence, Prevalence and Mortality from Melanoma in Spain

Objective: The incidence and mortality rates for cutaneous melanoma (CM) have increased markedly in the last few years. As such, the aim of this study was to forecast their progression in Spain up until 2022. Design: A prospective epidemiological study using the Miamod technique. The primary data source was the mortality statistics released by the National Statistics Institute. Study selection: The MIAMOD method was used. Data extraction: Cases of death due to general and melanoma-related mortality in Spain between 1998 and 2007. Results: In men, the incidence is expected to increase from 11.85 (adjusted: 8.52) to 14.79 (adjusted: 9.43) per 100,000 inhabitants over the period 1998-2022. Similarly, the mortality is expected to increase slightly from 5.84 (adjusted: 4.12) to 7.19 (adjusted: 4.49) per 100,000 inhabitants, and the prevalence from 73.72 (adjusted: 52.31) to 95.46 (adjusted: 60.02) per 100,000 inhabitants over the same period. In women, the incidence is expected to increase from 3.79 (adjusted: 3.04) to 6.46 (adjusted: 4.21) per 100,000 inhabitants between 1998 and 2022, although this increase is not statistically significant. The mortality is expected to increase from 1.67 (adjusted: 1.24) to 2.98 (adjusted: 1.86) per 100,000 inhabitants, and the prevalence from 50.04 (adjusted: 44.54) to 84.81 per (adjusted: 56.18) 100,000 inhabitants over the same period. Conclusions: Primary and secondary prevention programs for this disease must be maintained.
Software validation via scalable path-sensitive value flow analysis

In this paper, we present a new algorithm for tracking the flow of values through a program. Our algorithm represents a substantial improvement over the state of the art. Previously described value flow analyses that are control-flow sensitive do not scale well, nor do they eliminate value flow information from infeasible execution paths (i.e., they are path-insensitive). Our algorithm scales to large programs, and it is path-sensitive.The efficiency of our algorithm arises from three insights: The value flow problem can be "bit-vectorized" by tracking the flow of one value at a time; dataflow facts from different execution paths with the same value flow information can be merged; and information about complex aliasing that affects value flow can be plugged in from a different analysis.We have incorporated our analysis in ESP, a software validation tool. We have used ESP to validate the Windows operating system kernel (a million lines of code) against an important security property. This experience suggests that our algorithm scales to large programs, and is accurate enough to trace the flow of values in real code.
High Performance VMM-Bypass I/O in Virtual Machines

Currently, I/O device virtualization models in virtual machine (VM) environments require involvement of a virtual machine monitor (VMM) and/or a privileged VM for each I/O operation, which may turn out to be a performance bottleneck for systems with high I/O demands, especially those equipped with modern high speed interconnects such as InfiniBand. In this paper, we propose a new device virtualization model called VMM-bypass I/O, which extends the idea of OS-bypass originated from user-level communication. Essentially, VMM-bypass allows time-critical I/O operations to be carried out directly in guest VMs without involvement of the VMM and/or a privileged VM. By exploiting the intelligence found in modern high speed network interfaces, VMM-bypass can significantly improve I/O and communication performance for VMs without sacrificing safety or isolation. To demonstrate the idea of VMM-bypass, we have developed a prototype called Xen-IB, which offers InfiniBand virtualization support in the Xen 3.0 VM environment. Xen-IB runs with current InfiniBand hardware and does not require modifications to existing user-level applications or kernel-level drivers that use InfiniBand. Our performance measurements show that Xen-IB is able to achieve nearly the same raw performance as the original InfiniBand driver running in a non-virtualized environment.
The ArcB Leucine Zipper Domain Is Required for Proper ArcB Signaling

The Arc two-component system modulates the expression of numerous genes in response to respiratory growth conditions. This system comprises ArcA as the response regulator and ArcB as the sensor kinase. ArcB is a tripartite histidine kinase whose activity is regulated by the oxidation of two cytosol-located redox-active cysteine residues that participate in intermolecular disulfide bond formation. Here, we report that the ArcB protein segment covering residues 70–121, fulfills the molecular characteristics of a leucine zipper containing coiled coil structure. Also, mutational analyses of this segment reveal three different phenotypical effects to be distributed along the coiled coil structure of ArcB, demonstrating that this motif is essential for proper ArcB signaling.
Prognostic value of the Glasgow prognostic score in colorectal cancer: a meta-analysis of 9,839 patients

Purpose The aim of this study was to perform a systematic review and meta-analysis to evaluate the value of the Glasgow prognostic score (GPS) or modified Glasgow prognostic score (mGPS) in patients with colorectal cancer (CRC). Methods A comprehensive medical literature search was performed using the online databases PubMed, Embase, Web of Science, and the Cochrane Library. After extracting basic characteristics and prognostic data from the included studies, overall survival (OS) and cancer-specific survival (CSS) were pooled as primary outcomes. Subgroup analyses were performed according to therapeutic strategies, models, cutoff values, regions, tumor, node, metastasis stages, sample size, and ages. Results Forty-three independent cohorts from 41 studies with 9,839 CRC patients were included in the present study. Correlation between GPS or mGPS and OS was analyzed in 32 cohorts of 7,714 patients, and 23 independent cohorts of 5,375 patients focused on the correlation between GPS or mGPS and CSS. The overall outcomes showed that patients with elevated GPS or mGPS were associated with poor OS (HR: 2.20, 95% CI: 1.88–2.57, P<0.001). Elevated GPS or mGPS also resulted in worse CSS (HR: 1.86, 95% CI: 1.59–2.17, P<0.001). The results of the subgroup analyses confirmed the overall outcomes. Conclusion GPS or mGPS is an accurate prognostic predictor in patients with CRC. Patients with elevated pretreatment GPS or mGPS have a poor prognosis. Subgroup analyses confirmed the overall outcomes. Pretreatment GPS is a useful biomarker in the management of CRC.
Being on PAR: Outcomes of a Pilot Trial to Improve Mental Health and Wellbeing in the Workplace With the Promoting Adult Resilience (PAR) Program

Abstract There is an urgent need to find strategies to promote positive mental health in the workplace. The current study presents outcomes of a pilot trial of the Promoting Adult Resilience (PAR) program, an innovative mental health promotion program, which is conducted in the workplace over 11 weekly sessions. The PAR program is a strengths-based resilience-building program that integrates interpersonal and cognitive–behaviour therapy (CBT) perspectives. Pre-, post- and follow-up measures on 20 PAR participants from a resource-sector company were compared with a non-intervention-matched comparison group. At follow-up, the PAR group had maintained significant post-test improvements in coping self-efficacy and lower levels of stress and depression, and reported greater work-life fit than the comparison group. The program appeared to be ecologically valid and treatment integrity was maintained. Process evaluations of PAR program showed that skills were rated highly and widely used in everyday life at both post and follow-up measurement times.
In silico alchemy: A tutorial for alchemical free-energy perturbation calculations with NAMD

This tutorial explains how NAMD and related tools can be used to setup and perform alchemical free-energy simulations within the free-energy perturbation (FEP) theory. The force-field independent, “zero-sum” transformation of ethane into ethane is used as an introductory, prototypical example. FEP is then used to compute the free energy of charging a naked Lennard-Jones particle into a sodium ion. Next, the variation in solvation free energy upon mutation of a tyrosine residue into alanine is examined in the Ala–Tyr–Ala tripeptide. Last, the concept of standard binding free energy is illustrated in the simple case of a potassium ion binding an ionophore, 18–crown–6. Prior knowledge of NAMD and standard molecular dynamics simulations is assumed.
Assessing the Value of Interorganizational Systems to Support Business Transactions

Abstract: In interorganizational settings, the use of information systems (IS) and networks is often not formally evaluated, and decisions are made by “gut feeling” rather than based on rational evidence. Since benefits depend not only on internal contingencies but also on the decisions and loyalty of business partners, issues of trust and the risk of becoming locked in with a disloyal partner become crucial. The Internet and Web-based technologies, by facilitating system development and the deployment of interorganizational systems (lOSt may help change this picture. In times when IT use is becoming more and more important for firms to remain competitive and efficient, system costs and benefits have to be carefully balanced in order to build systems that are perceived as beneficial even in cases where risk aversion makes this difficult. This paper examines applications that support interfirm business transactions, in particular those that involve buying processes. A conceptual model for the evaluation of investments is introduced that takes into account the perspectives of the initiator and the prospective participants. The model is applied to a system developed by the lawrence livermore National laboratory (llNl) to link it with suppliers and support purchasing processes.
Modifying Ligand-Induced and Constitutive Signaling of the Human 5-HT4 Receptor

G protein–coupled receptors (GPCRs) signal through a limited number of G-protein pathways and play crucial roles in many biological processes. Studies of their in vivo functions have been hampered by the molecular and functional diversity of GPCRs and the paucity of ligands with specific signaling effects. To better compare the effects of activating different G-protein signaling pathways through ligand-induced or constitutive signaling, we developed a new series of RASSLs (receptors activated solely by synthetic ligands) that activate different G-protein signaling pathways. These RASSLs are based on the human 5-HT4b receptor, a GPCR with high constitutive Gs signaling and strong ligand-induced G-protein activation of the Gs and Gs/q pathways. The first receptor in this series, 5-HT4-D100A or Rs1 (RASSL serotonin 1), is not activated by its endogenous agonist, serotonin, but is selectively activated by the small synthetic molecules GR113808, GR125487, and RO110-0235. All agonists potently induced Gs signaling, but only a few (e.g., zacopride) also induced signaling via the Gq pathway. Zacopride-induced Gq signaling was enhanced by replacing the C-terminus of Rs1 with the C-terminus of the human 5-HT2C receptor. Additional point mutations (D66A and D66N) blocked constitutive Gs signaling and lowered ligand-induced Gq signaling. Replacing the third intracellular loop of Rs1 with that of human 5-HT1A conferred ligand-mediated Gi signaling. This Gi-coupled RASSL, Rs1.3, exhibited no measurable signaling to the Gs or Gq pathway. These findings show that the signaling repertoire of Rs1 can be expanded and controlled by receptor engineering and drug selection.
Mindfulness-based treatment approaches : clinician's guide to evidence base and applications

Eastern spiritual traditions have long maintained that mindfulness meditation can improve well-being. More recently, mindfulness-based treatment approaches have been successfully utilized to treat anxiety, depressive relapse, eating disorders, psychosis, and borderline personality disorder. This book discusses the conceptual foundation, implementation, and evidence base for the four best-researched mindfulness treatments: mindfulness-based stress reduction (MBSR), mindfulness-based cognitive therapy (MBCT), dialectical behavior therapy (DBT) and acceptance and commitment therapy (ACT). All chapters were written by researchers with extensive clinical experience. Each chapter includes the conceptual rationale for using a mindfulness-based treatment and a review of the relevant evidence base. A detailed case study illustrates how the intervention is implemented in 'real life', exploring the clinical and practical issues that may arise and how they can be managed. This book will be of use to clinicians and researchers interested in understanding and implementing mindfulness based treatments. It offers a comprehensive introduction to the best-researched mindfulness-based treatments. It covers wide range of problems & disorders (anxiety, depression, eating, psychosis, personality disorders, stress, pain, relationship problems, etc). It discusses a wide range of populations (children, adolescents, older adults, couples). It includes wide range of settings (outpatient, inpatient, medical, mental health, workplace). It also includes clinically rich, illustrative case study in every chapter. International perspectives are represented (authors from US, Canada, Britain, Sweden).