Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluating Bayesian spatial methods for modelling species distributions with clumped and restricted occurrence data

1. Statistical approaches for inferring the spatial distribution of taxa (Species Distribution Models, SDMs) commonly rely on available occurrence data, which is often non-randomly distributed and geographically restricted. Although available SDM methods address some of these problems, the errors could be more directly and accurately modelled using a spatially-explicit approach. Software to implement spatial autocorrelation terms into SDMs are now widely available, but whether such approaches for inferring SDMs are an improvement over existing methodologies is unknown. 2. Here, within a simulated environment using 1000 generated species’ ranges, we compared the performance of two commonly used non-spatial SDM methods (Maximum Entropy Modelling, MAXENT and Boosted Regression Trees, BRT) to a spatially-explicit Bayesian SDM method (Integrated Laplace Approximation, INLA), when the underlying data exhibit varying combinations of clumping and geographic restriction. Finally, we tested whether any recommended methodological settings for all methods were further impacted by spatially non-random patterns in these data. 3. Spatially-explicit INLA was the most consistently accurate method, being most or equal most accurate in 5 out of 8 data sampling scenarios. Within high-coverage sample datasets, all methods performed fairly similarly, but when sampling points were randomly spread BRT had a 1-3% greater accuracy over the other methods and when samples were clumped, spatial-INLA had a 4%-8% better in AUC score. Alternatively, when sampling points were restricted to a small section of the true range, all methods were on average 10-12% less accurate, with higher variation among the methods. None of the recommended settings for the different methods were found to be sensitive to clumping or restriction of data, except the complexity of the INLA spatial term. 4. INLA-based modelling approaches can be successfully used to account for spatial autocorrelation in an SDM context and, by taking account of random effects, produce outputs that can better elucidate the role of covariates in predicting species occurrence. Given that it is often unclear what the drivers are behind data clumping in an empirical occurrence dataset, or indeed how geographically restricted these data are, spatially-explicit INLA-based SDMs may be the better choice when modelling the spatial distribution of target species.
Value of color Doppler ultrasonography in the evaluation of orbital vascular flow in end-stage renal disease patients undergoing hemodialysis

Purpose: To evaluate choroidal and retinal vascular flow dynamics by means of color Doppler ultrasonography in patients with end-stage renal disease undergoing hemodialysis and to compare these findings with healthy controls. Material and Methods: Color Doppler ultrasonography and spectral analysis of nasal and temporal posterior ciliary and central retinal artery flow of both eyes were performed in 20 patients (40 eyes) and 22 controls (44 eyes) to assess peak systolic flow velocity, end-diastolic flow velocity, and resistive indices (RI). Patients with hypertension, diabetes mellitus, and any cardiac pathology were not included in the study. A general ophthalmologic examination was performed in all patients and controls. Results: The average peak-systolic and end-diastolic blood flow velocities of nasal (12.88±4.91/6.88±3.26) and temporal (15.22±9.59/6.41±3.97) posterior ciliary artery and central retinal artery (14.94±8.38/6.7±4.13) in patients were significantly higher than the corresponding values of the controls. The RI values of nasal (0.52±0.10) and temporal (0.58±0.12) posterior ciliary artery and central retinal artery (0.55±0.11) in patients with end-stage renal disease undergoing hemodialysis were significantly lower than in the controls. Conclusion: Choroidal and retinal blood flow velocities are higher and RI values for all three vessels lower in patients with end-stage renal disease undergoing hemodialysis compared to healthy controls. These alterations may be related to either increased choroidal blood flow or vasoconstriction of the proximal vessels.
Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement

Although MMP-28 is involved in numerous important physiologic and pathologic conditions, the mechanisms of action of this secreted proteinase is not well understood. We now have demonstrated that furin serves as an intermolecular chaperone for MMP-28 secretion by interacting with the propeptide domain of MMP-28. Employing COS-1 cells transfected with MMP-28 cDNA, protein levels of MMP-28 were quite low in conditioned media as compared to cell lysates. Coexpression of MMP-28 with furin cDNA resulted in markedly enhanced MMP-28 secretion. Contrary to expectation, cleavage of MMP-28 at the furin consensus sequence did not occur and proteolytic inactive furin was equally effective in enhancing MMP-28 secretion. Furin and MMP-28 coimmunoprecipitated and were partially coimmunolocalized in the cytoplasm of transfected cells. Cotransfection with furin cDNA also enhanced MMP-28 induced cell migration. In conclusion, our data provide a novel mechanism for MMP-28 function in cells in which furin serves as an intermolecular chaperone.
Comparing the national economic burden of five chronic conditions.

Using a nationally representative sample of 23,230 U.S. residents, we examine patterns of economic burden across five chronic conditions: mood disorders, diabetes, heart disease, asthma, and hypertension. Almost half of U.S. health care costs in 1996 were borne by persons with one or more of these five conditions; of that spending amount, only about one-quarter was spent on treating the conditions themselves and the remainder on coexistent illnesses. Each condition demonstrated substantial economic burden but also unique characteristics and patterns of service use driving those costs. The findings highlight the differing challenges involved in understanding needs and improving care across particular chronic conditions.
Electrical structure beneath the northern MELT line on the East Pacific Rise at 15°45′S

The electrical structure of the upper mantle beneath the East Pacific Rise (EPR) at 15°45′S is imaged by inverting seafloor magnetotelluric data obtained during the Mantle ELectromagnetic and Tomography (MELT) experiment. The electrical conductivity model shows no evidence for a conductive region immediately beneath the ridge, in contrast to the model previously obtained beneath the EPR at 17°S. This observation can be explained by differences in current melt production along the ridge, consistent with other observations. The mantle to the east of the ridge at 60 –100 km depth is anisotropic, with higher conductivity in the spreading direction compared to the along‐strike direction, similar to the 17°S region. The high conductivity in the spreading direction can be explained by a hydrated mantle with strain‐induced lattice preferred orientation of olivine or by partial melt preferentially connected in the spreading direction.
Psychological Motives and Online Games Addiction: ATest of Flow Theory and Humanistic Needs Theory for Taiwanese Adolescents

Obviously, the negative impact of online games has received much attention as well as having become a popular research topic. This research explored, from flow theory and humanistic needs theory, the psychological motivations of Taiwanese adolescents who are addicted to online games. The purpose of Study 1 was to investigate the relationship between players' flow state and their online games addiction. The results indicated that flow state was negatively correlated with addictive inclination and it was not a significant predictor for players' subsequent additive inclination. Findings also revealed that the addicts' flow state was significantly lower than the nonaddicts. Thus, flow state might not be the key psychological mechanism of players' addiction. In Study 2, the results showed that the psychological needs of players of online games were close to the two-factor theory which depicts satisfaction and dissatisfaction dimensions. Addicted players' need-gratification was similar to the feature of dissatisfactory factor. That is, the absence of playing online games is more likely to generate sense of dissatisfaction; the addicts' compulsive use of online games seems to stem from the relief of dissatisfaction rather than the pursuit of satisfaction. In contrast, online games tend to provide the nonaddicts with a sense of satisfaction rather than a sense of dissatisfaction.
Consumers' satisfaction with primary health services in the city of Jeddah, Saudi Arabia.

OBJECTIVE To study consumers' satisfaction and socio-demographic correlates of satisfaction with services provided by Primary Health Care Centres in the city of Jeddah. METHODS Study subjects included the consumers visiting the Primary Health Care Centres during the study period. Four Primary Health Care Centres were randomly selected from Jeddah according to the geographical location. Seventy five subjects were selected systematically where every tenth Saudi aged 15 years or above was chosen. Data was collected via a self administered pilot tested questionnaire which included socio-demographic characteristics, as well as the overall and differential satisfaction with the different services and facilities in the selected Primary Health Care Centres rated on a scale of 1 - 5 points, the higher the score the higher the satisfaction. RESULTS Male subjects constituted 60% of the visitors. More than half of the subjects were young 15-29 years of age, about 58% were married, 50% completed intermediate/secondary school, more than two fifths of the subjects were employees and more than three quarters have a monthly income of 6000 Saudi Riyals or less. The summary satisfaction score was 3.76 points and the overall satisfaction with the services provided was 2.45 points out of a maximum of 5 points. The highest satisfaction was for dental clinic (3.44 points) and the lowest for co- operation of the receptionist (1.95 point). Unskilled laborers showed the highest summary and overall satisfaction (4.31 and 2.71 points) and students showed the lowest satisfaction scores (3.54 and 1.89 points). Other socio-demographic variables were not significantly related to summary and overall satisfaction scores. CONCLUSION Measuring satisfaction by asking one summary question tends to give a significantly higher satisfaction score compared to satisfaction score taking in consideration of all services offered. Certain service components need corrective intervention measures to make them more satisfactory to consumers.
Brucella species release a specific, protease-sensitive, inhibitor of TNF-alpha expression, active on human macrophage-like cells.

Brucella species can establish themselves and cause disease in humans, but the mechanisms by which brucellae evade the antibacterial defenses of their host remain largely unknown. We have previously reported that, unlike Escherichia coli K12, intracellular pathogens from the genus Brucella survive and multiply within U937-derived phagocytes, and live Brucella organisms failed to induce TNF-alpha release upon infection. Moreover, exogenously added TNF-alpha restricted intracellular growth of Brucella species. Herein, we demonstrate that Brucella-infected U937 cells are activated to express IL-1 beta and IL-6 at both the mRNA and protein levels, while they cannot accumulate TNF-alpha mRNA. When physically separated from macrophages, live brucellae impaired TNF-alpha production in E. coli-infected cells. Moreover, in agonist-activated macrophages, supernatants from Brucella cultures promoted an inhibition of the induction of both TNF-alpha expression and release, without affecting IL-1 beta or IL-6 induction. These phenomena, observed whatever the Brucella strain assayed, show that brucellae release some high m.w. factor(s) that specifically inhibits TNF-alpha expression in activated human macrophages. The proteic nature of the factor(s) was demonstrated by its heat and protease sensitiveness, and this could explain why U937-derived macrophages did release TNF-alpha when infected with chloramphenicol-treated brucellae. We also found that the Brucella factor(s) specifically acts on human macrophagic cells, but not on murine macrophage-like cells. Our findings provide direct evidence that a secreted Brucella virulence factor(s) inhibiting TNF-alpha expression might contribute to the evasion of Brucella organisms from human antimicrobial defenses.
Conditional Knockout of NMDA Receptors in Dopamine Neurons Prevents Nicotine-Conditioned Place Preference

Nicotine from smoking tobacco produces one of the most common forms of addictive behavior and has major societal and health consequences. It is known that nicotine triggers tobacco addiction by activating nicotine acetylcholine receptors (nAChRs) in the midbrain dopaminergic reward system, primarily via the ventral tegmental area. Heterogeneity of cell populations in the region has made it difficult for pharmacology-based analyses to precisely assess the functional significance of glutamatergic inputs to dopamine neurons in nicotine addiction. By generating dopamine neuron-specific NR1 knockout mice using cre/loxP-mediated method, we demonstrate that genetic inactivation of the NMDA receptors in ventral tegmental area dopamine neurons selectively prevents nicotine-conditioned place preference. Interestingly, the mutant mice exhibit normal performances in the conditioned place aversion induced by aversive air puffs. Therefore, this selective effect on addictive drug-induced reinforcement behavior suggests that NMDA receptors in the dopamine neurons are critical for the development of nicotine addiction.
Base Station Density Bounded by Maximum Outage Probability in Massive MIMO System

The base station (BS) density influences the coverage performance of cellular communication system. In massive multiple input multiple output (MIMO) system, each BS is equipped with large scale antenna array. The stochastic geometric model is employed because of its analytical tractability. This paper demonstrates that BS density has to be below a certain bound in order to satisfy the coverage requirement in massive MIMO system. Closed-form expression for the BS density bounded by maximum outage probability is derived using Lambert W function. Moreover, the expression for the upper bound of successful area spectral efficiency (ASE) is also derived. Our study claims that increasing BS density will lead to the deterioration of coverage performance in massive MIMO system.
FDI and Growth : a Causal Relationship

The paper examines the causal relationship between FDI and economic growth by using an innovative econometric methodology to study the direction of causality between the two variables. We apply our methodology, based on the Toda-Yamamoto test for causality, to time-series data covering the period 1969-2000 for three developing countries, namely Chile, Malaysia and Thailand, all of them major recipients of FDI with a different history of macroeconomic episodes, policy regimes and growth patterns. Our empirical findings clearly suggest that it is GDP that causes FDI in the case of Chile and not vice versa, while for both Malaysia and Thailand, there is a strong evidence of a bi-directional causality between the two variables. The robustness of the above findings is confirmed by the use of a bootstrap test employed to test the validity of our results.
Well-Typed Languages are Sound

Type soundness is an important property of modern programming languages. In this paper we explore the idea that "well-typed languages are sound": the idea that the appropriate typing discipline over language specifications guarantees that the language is type sound. We instantiate this idea for a certain class of languages defined using small step operational semantics by ensuring the progress and preservation theorems. Our first contribution is a syntactic discipline for organizing and restricting language specifications so that they automatically satisfy the progress theorem. This discipline is not novel but makes explicit the way expert language designers have been organizing a certain class of languages for long time. We give a formal account of this discipline by representing language specifications as (higher-order) logic programs and by giving a meta type system over that collection of formulas. Our second contribution is a methodology and meta type system for guaranteeing that languages satisfy the preservation theorem. Ultimately, we proved that language specifications that conform to our meta type systems are guaranteed to be type sound. We have implemented these ideas in the TypeSoundnessCertifier, a tool that takes language specifications in the form of logic programs and type checks them according to our meta type systems. For those languages that pass our type checker, our tool automatically produces a proof of type soundness that can be machine-checked by the Abella proof assistant. For those languages that fail our type checker, the tool pinpoints the design mistakes that hinder type soundness. We have applied the TypeSoundnessCertifier to a large number of programming languages, including those with recursive types, polymorphism, letrec, exceptions, lists and other common types and operators.
Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA-Mutant Breast Cancer

Purpose: Phosphatidylinositol 3-kinase (PI3K) inhibitors are being developed for the treatment of estrogen receptor α (ER)–positive breast cancer in combination with antiestrogens. Understanding the temporal response and pharmacodynamic effects of PI3K inhibition in ER+ breast cancer will provide a rationale for treatment scheduling to maximize therapeutic index. Experimental Design: Antiestrogen-sensitive and antiestrogen-resistant ER+ human breast cancer cell lines and mice bearing PIK3CA-mutant xenografts were treated with the antiestrogen fulvestrant, the PI3K inhibitor GDC-0941 (pictilisib; varied doses/schedules that provided similar amounts of drug each week), or combinations. Cell viability, signaling pathway inhibition, proliferation, apoptosis, tumor volume, and GDC-0941 concentrations in plasma and tumors were temporally measured. Results: Treatment with the combination of fulvestrant and GDC-0941, regardless of dose/schedule, was significantly more effective than that with single-agent treatments in fulvestrant-resistant tumors. Short-term, complete PI3K inhibition blocked cell growth in vitro more effectively than chronic, incomplete inhibition. Longer-term PI3K inhibition hypersensitized cells to growth factor signaling upon drug withdrawal. Different schedules of GDC-0941 elicited similar tumor responses. While weekly high-dose GDC-0941 with fulvestrant continuously suppressed PI3K signaling for 72 hours, inducing a bolus of apoptosis and inhibiting proliferation, PI3K reactivation upon GDC-0941 washout induced a proliferative burst. Fulvestrant with daily low-dose GDC-0941 metronomically suppressed PI3K for 6 to 9 hours/day, repeatedly inducing small amounts of apoptosis and temporarily inhibiting proliferation, followed by proliferative rebound compared with fulvestrant alone. Conclusions: Continuous and metronomic PI3K inhibition elicits robust anticancer effects in ER+, PIK3CA-mutant breast cancer. Clinical exploration of alternate treatment schedules of PI3K inhibitors with antiestrogens is warranted. Clin Cancer Res; 22(9); 2250–60. ©2016 AACR. See related commentary by Toska and Baselga, p. 2099
The relationship between adult attachment and trauma

Prior research has suggested a complex relationship between childhood interpersonal traumas perpetrated by attachment figures and the experience of trauma in adulthood. Very little is known, however, about how various forms of childhood interpersonal abuse and neglect affect trauma sequelae and adult romantic attachment in women during the childbearing years. Using a sample of postpartum women (N = 104), this study examined the associations between a history of attachment-related traumas (operationalized as childhood interpersonal abuse and neglect) and complex trauma sequelae believed to be unique to victims of interpersonal traumas; the possible role that adult romantic attachment anxiety and avoidance (i.e., insecurity-security) may have in understanding these associations was also investigated. This study also examined the associations between secure base scripts, or cognitive structures thought to underlie internal working models of attachment established early in life, and attachment-related traumas, the adult romantic attachment dimensions of anxiety and avoidance, and complex trauma outcomes. Results of this study indicated that attachment-related traumas were associated with adult romantic attachment anxiety and avoidance and complex trauma outcomes, and that adult romantic attachment insecurity-security may be an important mechanism by which early attachment-related traumas influence later complex trauma outcomes. In addition, while results indicated a significant relationship between the two types of secure base scripts, findings revealed no relationship between secure base scriptedness and attachment-related traumas or adult romantic attachment insecurity-security. Finally, both types of secure base scriptedness were related to a self-report measure of trauma-related cognitions. Implications of study findings are discussed in light of previous literature and attachment and trauma theories. Adult Attachment and Trauma v Table of
Operator algebra in logarithmic conformal field theory

For some time now, conformal field theories in two dimensions have been studied as integrable systems. Much of the success of these studies is related to the existence of an operator algebra of the theory. In this paper, some of the extensions of this machinery to the logarithmic case are studied and used. More precisely, from M\"obius symmetry constraints, the generic three- and four-point functions of logarithmic quasiprimary fields are calculated in closed form for arbitrary Jordan rank. As an example, $c=0$ disordered systems with nondegenerate vacua are studied. With the aid of two-, three-, and four-point functions, the operator algebra is obtained and associativity of the algebra studied.
Striatal inhomogeneities and basal ganglia function

It has always been something of a mystery as to why different diseases of the basal ganglia may produce completely opposite effects on movement. Thus, defective dopaminergic inhibitory input into the striatum in Parkinson’s disease causes an akinetic-rigid syndrome, while destruction of the striatum in Huntington’s disease usually causes chorea. This theoretic paradox may be resolved by more detailed examination of the exact sites of striatal damage in the two opposing conditions (1). C. D. Marsden