Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of midpalatal suture ossification using cone-beam computed tomography

Background and Objective The degree of ossification of the midpalatal suture is an important factor in the selection of treatment procedure, especially in young individuals. Considering the discrepancies in the results of studies on the exact time of the closure of this suture, the present study was undertaken to evaluate ossification and morphology of the suture with the use of CBCT. Methods In the present cross-sectional study, the CBCT images of the maxilla in 144 Iranian subjects (72 males, 72 females) with an age range of 10 to 70 years, referring to a private radiology center in Sari, Iran, were evaluated. The CBCT images were evaluated in the axial cross-sectional slice at 1 mm intervals to determine morphology and the maturation stage of the suture and its degree of ossification. The six developmental stages that were observed were as follows: stage A, a direct line without disturbances; stage B, a scalloped appearance in the suture; stage C, two parallel lines with a scalloped appearance that were connected at some points; stage CD, the anterior portion was similar to stage C, and the posterior region was similar to stage D; stage D, ossification only in the palatine bone; stage E, complete ossification of the suture. The degree of ossification of the suture was calculated with the use of the ratio of the length of the ossified segment to the entire length of the suture. Data were analyzed with Spearman’s correlation test, Chi-squared test, t-test, ANOVA, Mann-Whitney U, and Kruskal-Wallis test. Intra-observer agreement was calculated with the use of weighted kappa coefficient. Data were analyzed with SPSS 17. Results There was a strong correlation between the age groups and the developmental stages of the midpalatal suture in both genders (r=0.681, p<0.001). The ossification process occurred in the posterior to anterior direction in 98% of the cases. There was a significant relationship between aging and the degree of ossification (p<0.001); however, the difference was not significant between the two genders (p=0.193). Conclusion Although the rate of suture closure increased with aging, age was not a reliable factor alone to determine the developmental stage of the suture. Use of CBCT is necessary in all the patients to determine the degree of ossification and morphology of the midpalatal suture.
[The personality].

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Real-time principal component pursuit

Robust principal component analysis (RPCA) deals with the decomposition of a matrix into a low-rank matrix and a sparse matrix. Such a decomposition finds, for example, applications in video surveillance or face recognition. One effective way to solve RPCA problems is to use a convex optimization method known as principal component pursuit (PCP). The corresponding algorithms have, however, prohibitive computational complexity for certain applications that require real-time processing. In this paper we propose a variety of methods that significantly reduce the computational complexity. Furthermore, we perform a systematic analysis of the performance/complexity tradeoffs underlying PCP. For synthetic data, we show that our methods result in a speedup of more than 365 times compared to a reference C implementation at only a small loss in terms of recovery error. To demonstrate the effectiveness of our approach, we consider foreground/background separation for video surveillance, where our methods enable real-time processing of a 640×480 color video stream at 12 frames per second (fps) using a quad-core CPU.
So far so good? A qualitative case study exploring the implementation of consultation in schools

This paper describes a small‐scale research project carried out one year after the implementation of a consultation model of service delivery within an Educational Psychology Service. Following a series of interviews held with special needs co‐ordinators, a hierarchy of development was identified, and conditions pertaining to this development isolated. Through identifying optimum conditions for the development of consultation, a number of specific recommendations are made, aimed at ensuring that all schools gain maximum benefit from this way of working.
Developmental toxicity evaluation of isopropanol by gavage in rats and rabbits.

Timed-pregnant CD (Sprague-Dawley) rats, 25/group, were dosed orally with aqueous isopropanol (IPA; CAS No. 67-63-0) solutions at 0, 400, 800, or 1200 mg/kg/day, once daily on Gestational Days (GD) 6 through 15 at a dosing volume of 5 ml/kg. Artificially inseminated New Zealand white rabbits, 15/group, were dosed orally with IPA at 0, 120, 240, or 480 mg/kg/day once daily on GD 6 through 18 at 2 ml/kg. Maternal body weights, clinical observations, and food consumption were recorded throughout gestation for both species. At scheduled euthanization for both species (GD 20, rats; GD 30, rabbits), fetuses were weighed, sexed, and examined for external, visceral (including craniofacial) and skeletal alterations. For both species, the pregnancy rate was high and equivalent across all groups; no dams or does aborted, delivered early, or were removed from study. In rats, two dams (8%) died at 1200 mg/kg/day and one dam (4%) died at 800 mg/kg/day. Maternal body weights and weight gain were equivalent across all groups, except for statistically significantly reduced gestational weight gain (GD 0-20; 89.9% of control value), associated with statistically significantly reduced gravid uterine weight at 1200 mg/kg/day (89.2% of control value). There were no treatment-related clinical signs or effects on maternal food consumption. All gestational parameters evaluated were equivalent across groups, including pre- and postimplantation loss, fetal sex ratios, and litter size. Twenty-two to 25 litters were examined per group. Fetal body weights per litter were statistically significantly reduced at the two highest doses (97.3 (n.s.), 94.7, and 94.3% of controls at 800 mg/kg/day and 92.1, 91.9, and 95.4% of controls at 1200 mg/kg/day for all fetuses and males and females separately). No evidence of increased teratogenicity was observed at any dose tested in rats. In rabbits, four does (26.7%) died at 480 mg/kg/day. Maternal body weights were statistically significantly reduced during treatment (GD 6-18) at 480 mg/kg/day (45.4% of control value) with a nonsignificant reduction in gestational weight change (GD 0-30; 77.3% of control value) at this dose. Profound clinical signs of toxicity and statistically significantly reduced maternal food consumption were observed at 480 mg/kg/day. All gestational parameters were equivalent across all doses administered. Thirteen to 15 litters were evaluated per group except for the 480 mg/kg/day group with 11 litters (due to maternal deaths). There were no treatment-related effects on pre- or postimplantation loss, fetal sex ratio, litter size, or fetal body weight/litter. Moreover, no evidence was found of increased teratogenicity at any dose tested in rabbits. Therefore, IPA was not teratogenic to CD rats or to NZW rabbits. The NOAELS for both maternal and developmental toxicity were 400 mg/kg/day in rats, and were 240 and 480 mg/kg/day, respectively, in rabbits.
Understanding the Process of Constructing Scales Inventories in the Process Modelling Domain

Empirical research strategies are undisputedly of paramount importance to rigorous and relevant IS research. Employed practices of empirical research in Information Systems, however, are still considered to be problematic. One related problem in this context is the lack of rigorously developed and tested empirical scales inventories that could be used in empirical studies of artefacts relevant to Information Systems. This paper reports on the process of developing research tools for usage in empirical studies of Information Systems artefacts. We use the domain of business process modelling as an example of a relevant IS research domain and report on the development of an scales inventory to measure the various perceptions that individuals may have towards acceptance and continuance of process modelling languages. We describe a multi-stage development approach for scales creation that incorporates feedback from both expert and user perspectives. Our research in progress results in a pre-validated scales inventory that can be used to assist in further empirical studies that study phenomena associated with the business process modelling domain.
Problems and progress: survey on fat points in P2

This paper surveys certain problems involving numerical characters for ideals I(Z) defining fat points subschemes $Z=m_1p_1+. +m_np_n$ for general points $p_i\in {\bf P}^2$. It also presents some new results, and includes a suite of MACAULAY 2 scripts for computing actual or conjectured values of (or bounds on) these characters. One such script, for example, is findres, which implements an algorithm due to Fitchett, Harbourne and Holay for computing the syzygy modules in a minimal free resolution of the ideal I(Z) for any such Z with n<=8; since findres does not rely on a Gr\"obner basis calculation, it is very fast and can handle very large multiplicities.
The environmental dependence of radio-loud AGN activity and star formation in the 2dFGRS

By combining the 2-degree Field Galaxy Redshift Survey with the NRAO VLA Sky Survey at 1.4 GHz, the environments of radio-loud active galactic nuclei (AGN) in the nearby Universe are investigated using both local projected galaxy densities and a friends-of-friends group-finding algorithm. Radio-loud AGN are preferentially located in galaxy groups and poor-to-moderate richness galaxy clusters. The AGN fraction appears to depend more strongly on the large-scale environment (group, cluster, etc.) in which a galaxy is located than on its more local environment, except at the lowest galaxy surface densities where practically no radio-loud AGN are found. The ratio of absorption-line to emission-line AGN changes dramatically with environment, with essentially all radio-loud AGN in rich environments showing no emission lines. This result could be connected with the lack of cool gas in cluster galaxies, and may have important consequences for analyses of optically selected AGN, which are invariably selected on emission-line properties. The local galaxy surface density of the absorption-line AGN is strongly correlated with radio luminosity, implying that the radio luminosities may be significantly boosted in dense environments due to confinement by the hot intracluster gas. The environments of a radio-selected sample of star-forming galaxies are also investigated to provide an independent test of optical studies. In line with those studies, the fraction of star-forming galaxies is found to decrease strongly with increasing local galaxy surface density; this correlation extends across the whole range of galaxy surface densities, with no evidence for the density threshold found in some optical studies.
Investigation of the Cross-Ratios Method for Point-of-Gaze Estimation

The cross-ratios method for point-of-gaze (PoG) estimation uses the invariance property of cross-ratios in projective transformations. The inherent causes of the subject-dependent PoG estimation bias exhibited by this method have not been well characterized in the literature. Using a model of the eye and the components of a system (camera, light sources) that estimates PoG, a theoretical framework for the cross-ratios method is developed. The analysis of the cross-ratios method within this framework shows that the subject-dependent estimation bias is caused mainly by: 1) the angular deviation of the visual axis from the optic axis and 2) the fact that the virtual image of the pupil center is not coplanar with the virtual images of the light sources that illuminate the eye (corneal reflections). The theoretical framework provides a closed-form analytical expression that predicts the estimation bias as a function of subject-specific eye parameters. The theoretical framework also provides a clear physical interpretation for an existing empirically derived two-step procedure that compensates for the estimation bias and shows that the first step of this procedure is equivalent to moving the corneal reflections to a new plane that minimizes the distance from this plane to the virtual image of the pupil center.
Spatial and temporal frequency tuning in striate cortex: functional uniformity and specializations related to receptive field eccentricity

In light of anatomical evidence suggesting differential connection patterns in central vs. peripheral representations of cortical areas, we investigated the extent to which the response properties of cells in the primary visual area (V1) of the marmoset change as a function of eccentricity. Responses to combinations of the spatial and temporal frequencies of visual stimuli were quantified for neurons with receptive fields ranging from 3° to 70° eccentricity. Optimal spatial frequencies and stimulus speeds reflected the expectation that the responses of cells throughout V1 are essentially uniform, once scaled according to the cortical magnification factor. In addition, temporal frequency tuning was similar throughout V1. However, spatial frequency tuning curves depended both on the cell’s optimal spatial frequency and on the receptive field eccentricity: cells with peripheral receptive fields showed narrower bandwidths than cells with central receptive fields that were sensitive to the same optimal spatial frequency. Although most V1 cells had separable spatial and temporal frequency tuning, the proportion of neurons displaying significant spatiotemporal interactions increased in the representation of far peripheral vision (> 50°). In addition, of the fewer than 5% of V1 cells that showed robust (spatial frequency independent) selectivity to stimulus speed, most were concentrated in the representation of the far periphery. Spatiotemporal interactions in the responses of many cells in the peripheral representation of V1 reduced the ambiguity of responses to high‐speed (> 30°/s) signals. These results support the notion of a relative specialization for motion processing in the far peripheral representations of cortical areas, including V1.
Have early postoperative complications from laparoscopic rectal cancer surgery improved over the past 20 years?

Laparoscopic rectal cancer surgery has been increasingly used since 1991 following the publication of the first case series. Since then, several studies have confirmed that laparoscopic surgery for rectal cancer is challenging with associated morbidity and mortality. The aim of this study was to determine if the rates of early postoperative complications in laparoscopic rectal cancer surgery have improved over the past 20 years.
The Discovery of America

I propose a new scenario for the discovery of America. By analogy with other successful animal invasions, one may assume that the discovery of the New World triggered a human population explosion. The invading hunters attained their highest population density along a front that swept from Canada to the Gulf of Mexico in 350 years, and on to the tip of South America in roughly 1000 years. A sharp drop in human population soon followed as major prey animals declined to extinction. Possible values for the model include an average frontal depth of 160 kilometers, an average population density of 0.4 person per square kilometer on the front and of 0.04 person per square kilometer behind the front, and an average rate of frontal advance of 16 kilometers per year. For the first two centuries the maximum rate of growth may have equaled the historic maximum of 3.4 percent annually. During the episode of faunal extinctions, the population of North America need not have exceeded 600,000 people at any one time. The model generates a population sufficiently large to overkill a biomass of Pleistocene large animals averaging 9 metric tons per square kilometer (50 animal units per section) or 2.3 x 108 metric tons in the hemisphere. It requires that on the front one person in four destroy one animal unit (450 kilograms) per week, or 26 percent of the biomass of an average section in 1 year in any one region. Extinction would occur within a decade. There was insufficient time for the fauna to learn defensive behaviors, or for more than a few kill sites to be buried and preserved for the archeologist. Should the model survive future findings, it will mean that the extinction chronology of the Pleistocene megafauna can be used to map the spread of Homo sapiens throughout the New World.
Cultural sexism in the UK airline industry

Purpose – The purpose of this paper is to examine cultural sexism in the UK aviation industry through the experiences women commercial pilots have encountered with their male colleagues and management.Design/methodology/approach – Interviews were carried out with 20 women commercial airline pilots: 17 women were currently airline pilots, or were previously airline pilots and resigned and three women were flying instructors. There were nine different UK airlines for which the women airline pilots worked.Findings – Women pilots face cultural sexism where their male colleagues expect them to be different based on their assumptions about women in general but expect their female colleagues to adapt to the current social and cultural system in the UK industry.Research limitations/implications – Further research is needed to explore ways to combat cultural sexism. Limitations include a focus on UK airlines only, plus the methodology relied upon women who were open to discussing their experiences rather than a ra.
Helicobacter pylori Membrane Vesicles Stimulate Innate Pro- and Anti-Inflammatory Responses and Induce Apoptosis in Jurkat T Cells

ABSTRACT Persistent Helicobacter pylori infection induces chronic inflammation in the human gastric mucosa, which is associated with development of peptic ulceration, gastric atrophy, and gastric adenocarcinoma. It has been postulated that secretion of immunomodulatory molecules by H. pylori facilitates bacterial persistence, and membrane vesicles (MV), which have the potential to cross the gastric epithelial barrier, may mediate delivery of these molecules to host immune cells. However, bacterial MV effects on human immune cells remain largely uncharacterized to date. In the present study, we investigated the immunomodulatory effects of H. pylori MV with and without the vacuolating cytotoxin, VacA, which inhibits human T cell activity. We show a high degree of variability in the toxin content of vesicles between two H. pylori strains (SS1 and 60190). Vesicles from the more toxigenic 60190 strain contain more VacA (s1i1 type) than vesicles from the SS1 strain (s2i2 VacA), but engineering the SS1 strain to produce s1i1 VacA did not increase the toxin content of its vesicles. Vesicles from all strains tested, including a 60190 isogenic mutant null for VacA, strongly induced interleukin-10 (IL-10) and IL-6 production by human peripheral blood mononuclear cells independently of the infection status of the donor. Finally, we show that H. pylori MV induce T cell apoptosis and that this is enhanced by, but not completely dependent on, the carriage of VacA. Together, these findings suggest a role for H. pylori MV in the stimulation of innate pro- and anti-inflammatory responses and in the suppression of T cell immunity.
A Large Image Database for Color Constancy Research

We present a study on various statistics relevant to research on color constancy. Many of these analyses could not have been done before simply because a large database for color constancy was not available. Our image database consists of approximately 11,000 images in which the RGB color of the ambient illuminant in each scene is measured. To build such a large database we used a novel set-up consisting of a digital video camera with a neutral gray sphere attached to the camera so that the sphere always appears in the field of view. Using a gray sphere instead of the standard gray card facilitates measurement of the variation in illumination as a function of incident angle. The study focuses on the analysis of the distribution of various illuminants in the natural scenes and the correlation between the rg-chromaticity of colors recorded by the camera and the rg-chromaticity of the ambient illuminant. We also investigate the possibility of improving the performance of the naive Gray World algorithm by considering a sequence of consecutive frames instead of a single image. The set of images is publicly available and can also be used as a database for testing color constancy algorithms.
Intolerance and discrimination

This article traces the origins of tolerance as a pragmatic policy of absolute monarchy through its transformation into an indispensable tool for the establishment of religious pluralism in a democratic polity. The author distinguishes between mere toleration of outsiders, who are nevertheless considered inferior, and toleration based on mutual recognition and mutual acceptance of divergent worldviews. This latter kind of tolerance allows religions and democracy to coexist in a pluralistic environment and paves the way to reconciliation between multiculturalism and equality.
Peripheral blood circulating cytokeratin-19 mRNA-positive cells after the completion of adjuvant chemotherapy in patients with operable breast cancer.

BACKGROUND The purpose of this study was to evaluate the prognostic significance of the molecular detection of cytokeratin 19 (CK-19) mRNA-positive cells in the peripheral blood of women with operable breast cancer after the completion of adjuvant chemotherapy. PATIENTS AND METHODS Blood from 161 patients with stage I and II breast cancer, obtained after the completion of adjuvant chemotherapy, was tested by nested RT-PCR for CK-19 mRNA detection. Using univariate and multivariate analyses possible interactions with other prognostic factors and association of CK-19 mRNA detection with risk of relapse, disease-free interval (DFI) and overall survival were investigated. RESULTS After completion of adjuvant chemotherapy, 27.3% of patients had peripheral blood CK-19 mRNA-positive cells; there was no association of this finding with any other prognostic factors or the type of chemotherapy regimen used. For patients with less than four involved axillary lymph nodes the risk of relapse was 3.81 [95% confidence interval (CI) 1.06-13.71] times higher, and the DFI was significantly reduced (P = 0.028) if CK-19 mRNA-positive cells were detectable in the blood after the completion of adjuvant chemotherapy. In contrast, for patients with four or more involved lymph nodes, the presence of CK-19 mRNA-positive cells after adjuvant chemotherapy did not significantly affect the risk of relapse or DFI. Furthermore, the risk of relapse was higher (hazards ratio 3.70; 95% CI 1.09-13.89) and the DFI was reduced (P = 0.022) for patients with detectable CK-19 mRNA-positive cells following adjuvant cyclophosphamide, methotrexate and 5-fluorouracil (CMF) as compared with epirubicin, cyclophosphamide and 5-fluorouracil (FEC) or sequential taxotere-epirubicin and cyclophosphamide (T/EC) chemotherapy. CONCLUSIONS The detection of CK-19 mRNA-positive cells in the peripheral blood after adjuvant chemotherapy may be of clinical relevance for patients with early breast cancer and less than four involved axillary lymph nodes.