Miracle-dz/UniFAR-FTUs huggingface dataset:
Multidrug-resistant Cancer Cells Facilitate E1-independent Adenoviral Replication

Resistance to chemotherapy is responsible for a failure of current treatment regimens in cancer patients. We have reported previously that the Y-box protein YB-1 regulates expression of the P-glycoprotein gene mdr1, which plays a major role in the development of a multidrug resistant-tumor phenotype. YB-1 predicts drug resistance and patient outcome in breast cancer. Thus, YB-1 is a promising target for new therapeutic approaches to defeat multidrug resistance. In drug-resistant cancer cells and in adenovirus-infected cells YB-1 is found in the nucleus. Nuclear accumulation of YB-1 in adenovirus-infected cells is a function of the E1 region, and we have shown that YB-1 facilitates adenovirus replication. Here we report that E1A-deleted or mutant adenovirus vectors, such as Ad312 and Ad520, replicate efficiently in multidrug-resistant (MDR) cancer cells and induce an adenovirus cytopathic effect resulting in host cell lysis. Thus, replication-defective adenoviruses are a previously unrecognized vector system for a selective elimination of MDR cancer cells. Our work forms the basis for the development of novel oncolytic adenovirus vectors for the treatment of MDR malignant diseases in the clinical setting.
A Diploid-Triploid (60,XX/90,XXY) Intersex in a Holstein Heifer

The diploid/triploid (60,XX/90,XXY) condition in Bos taurus is very rare and only three cases have been published previously. The present animal exhibited an aplastic vulva, penis and clitoris agenesis, a male-like urethra located in a pseudoprepuce opening between the mammary complexes and a well developed M. rectipeninus. A normal (60,XX) female karyotype was detected in lymphocyte cultures whereas uterus and tendon cells revealed a 60,XX/90,XXY mixoploidy. Quantification of X and Y chromosome-specific sequences using RT-PCR revealed extraordinary high Y chromosome equivalents in the sample recovered from the male-like transformed vestibulum vaginae suggesting a causative relationship. The pathogenesis of the missing clitoris and penis, which is contrasted by the concomitant presence of a well developed M. rectipeninus, remains difficult to explain. A chimeric origin is suggested despite the fact that microsatellite analysis of the animal’s blood cells displayed no un- usual allele accumulation.
Composite Adaptive Fuzzy Output Feedback Control Design for Uncertain Nonlinear Strict-Feedback Systems With Input Saturation

In this paper, a composite adaptive fuzzy output-feedback control approach is proposed for a class of single-input and single-output strict-feedback nonlinear systems with unmeasured states and input saturation. Fuzzy logic systems are utilized to approximate the unknown nonlinear functions, and a fuzzy state observer is designed to estimate the unmeasured states. By utilizing the designed fuzzy state observer, a serial-parallel estimation model is established. Based on adaptive backstepping dynamic surface control technique and utilizing the prediction error between the system states observer model and the serial-parallel estimation model, a new fuzzy controller with the composite parameters adaptive laws are developed. It is proved that all the signals of the closed-loop system are bounded and the system output can follow the given bounded reference signal. A numerical example and simulation comparisons with previous control methods are provided to show the effectiveness of the proposed approach.
An evaluation of SimRank and Personalized PageRank to build a recommender system for the Web of Data

The Web of Data is the natural evolution of the World Wide Web from a set of interlinked documents to a set of interlinked entities. It is a graph of information resources interconnected by semantic relations, thereby yielding the name Linked Data. The proliferation of Linked Data is for sure an opportunity to create a new family of data-intensive applications such as recommender systems. In particular, since content-based recommender systems base on the notion of similarity between items, the selection of the right graph-based similarity metric is of paramount importance to build an effective recommendation engine. In this paper, we review two existing metrics, SimRank and PageRank, and investigate their suitability and performance for computing similarity between resources in RDF graphs and investigate their usage to feed a content-based recommender system. Finally, we conduct experimental evaluations on a dataset for musical artists and bands recommendations thus comparing our results with two other content-based baselines measuring their performance with precision and recall, catalog coverage, items distribution and novelty metrics.
Regional homogeneity changes in early and advanced Parkinson ’ s disease : a resting state functional magnetic resonance imaging study

Objective: Previous work has shown regional homogeneity (ReHo) differences in Parkinson’s disease (PD) patients. So looking in more detail at differences between early and late stages is valuable. The aim of our study was to investigate brain activity of early and advanced PD in the resting state by using a ReHo approach. Methods: Functional magnetic resonance images were acquired in 35 patients with PD at in early stage and advanced stage, as well as in 17 ageand sex-matched normal controls (NC). Results: In PD patients compared with NC, we observed decreased ReHo in motor cortex and increased ReHo in the right cuneus and frontal eye field. In early stage of PD, decreased ReHo was located in bilateral posterior insular cortex, dorsolateral prefrontal cortex, angular gyrus, supramarginal gyrus, left precuneus, right superior temporal gyrus, and right cerebellar posterior lobe, in addition to motor cortex; and increased ReHo in the left cerebellar anterior lobe. During disease evolution, decreased ReHo was found in more brain areas, including right cerebellar posterior lobe, bilateral orbitofrontal cortex, gyrus rectus and left middle and inferior temporal gyrus; and increased ReHo in bilateral middle occipital gyrus, insular cortex, cingulate gyrus, superior temporal gyrus, and right middle temporal gyrus and thalamus. Whereas no changes were observed in bilateral motor cortex. Conclusion: Our results indicate that neuronal activity decrease in motor cortex with no marked variation during disease progression in a resting state, and decreased cognitive function may be associated with worsening motor symptoms in PD.
Genetic correlation in relation to differences in dosage of a stressor

We exposed the strains of Chlamydomonas isolated from an outbred laboratory population to a range of concentrations of salt (NaCl) up to an extirpative level that the base population could not tolerate. The genetic variance of yield increased with stress over the first half of this range before collapsing to nearly zero. The genetic correlation decreased with environmental distance, whether measured as a difference in dosage or as an environmental variance. This result is consistent with previous studies and provides a basis for interpreting adaptation to a deteriorating environment and the process of evolutionary rescue.
Incidences of Unfavorable Events in the Management of Low-Risk Papillary Microcarcinoma of the Thyroid by Active Surveillance Versus Immediate Surgery

Background: The incidence of papillary microcarcinoma (PMC) of the thyroid is rapidly increasing globally, making the management of PMC an important clinical issue. Excellent oncological outcomes of active surveillance for low-risk PMC have been reported previously. Here, unfavorable events following active surveillance and surgical treatment for PMC were studied. Methods: From February 2005 to August 2013, 2153 patients were diagnosed with low-risk PMC. Of these, 1179 patients chose active surveillance and 974 patients chose immediate surgery. The oncological outcomes and the incidences of unfavorable events of these groups were analyzed. Results: In the active surveillance group, 94 patients underwent surgery for various reasons; tumor enlargement and the appearance of novel lymph node metastases were the reasons in 27 (2.3%) and six patients (0.5%), respectively. One of the patients with conversion to surgery had nodal recurrence, and five patients in the immediate surgery group had a recurrence in a cervical node or unresected thyroid lobe. All of these recurrences were successfully treated. None of the patients had distant metastases, and none died of the disease. The immediate surgery group had significantly higher incidences of transient vocal cord paralysis (VCP), transient hypoparathyroidism, and permanent hypoparathyroidism than the active-surveillance group did (4.1% vs. 0.6%, p < 0.0001; 16.7% vs. 2.8%, p < 0.0001; and 1.6% vs. 0.08%, p < 0.0001, respectively). Permanent VCP occurred only in two patients (0.2%) in the immediate surgery group. The proportion of patients on L-thyroxine for supplemental or thyrotropin (TSH)-suppressive purposes was significantly larger in the immediate surgery group than in the active surveillance group (66.1% vs. 20.7%, p < 0.0001). The immediate surgery group had significantly higher incidences of postsurgical hematoma and surgical scar in the neck compared with the active surveillance group (0.5% vs. 0%, p < 0.05; and 8.0% vs. 100%, p < 0.0001, respectively). Conclusions: The oncological outcomes of the immediate surgery and active surveillance groups were similarly excellent, but the incidences of unfavorable events were definitely higher in the immediate surgery group. Thus, active surveillance is now recommended as the best choice for patients with low-risk PMC.
A new representation for protein secondary structure prediction based on frequent patterns

MOTIVATION A new representation for protein secondary structure prediction based on frequent amino acid patterns is described and evaluated. We discuss in detail how to identify frequent patterns in a protein sequence database using a level-wise search technique, how to define a set of features from those patterns and how to use those features in the prediction of the secondary structure of a protein sequence using support vector machines (SVMs). RESULTS Three different sets of features based on frequent patterns are evaluated in a blind testing setup using 150 targets from the EVA contest and compared to predictions of PSI-PRED, PHD and PROFsec. Despite being trained on only 940 proteins, a simple SVM classifier based on this new representation yields results comparable to PSI-PRED and PROFsec. Finally, we show that the method contributes significant information to consensus predictions. AVAILABILITY The method is available from the authors upon request.
HyperSentry: enabling stealthy in-context measurement of hypervisor integrity

This paper presents HyperSentry, a novel framework to enable integrity measurement of a running hypervisor (or any other highest privileged software layer on a system). Unlike existing solutions for protecting privileged software, HyperSentry does not introduce a higher privileged software layer below the integrity measurement target, which could start another race with malicious attackers in obtaining the highest privilege in the system. Instead, HyperSentry introduces a software component that is properly isolated from the hypervisor to enable stealthy and in-context measurement of the runtime integrity of the hypervisor. While stealthiness is necessary to ensure that a compromised hypervisor does not have a chance to hide the attack traces upon detecting an up-coming measurement, in-context measurement is necessary to retrieve all the needed inputs for a successful integrity measurement. HyperSentry uses an out-of-band channel (e.g., Intelligent Platform Management Interface (IPMI), which is commonly available on server platforms) to trigger the stealthy measurement, and adopts the System Management Mode (SMM) to protect its base code and critical data. A key contribution of HyperSentry is the set of novel techniques that overcome SMM's limitation, providing an integrity measurement agent with (1) the same contextual information available to the hypervisor, (2) completely protected execution, and (3) attestation to its output. To evaluate HyperSentry, we implement a prototype of the framework along with an integrity measurement agent for the Xen hypervisor. Our experimental evaluation shows that HyperSentry is a low-overhead practical solution for real world systems.
Structural and optical characterization of the formation of β-FeSi2 nanocrystallites in an n-type (100) Si matrix

Ion-beam synthesized (IBS) samples, prepared with a low dose of iron ions and subjected to rapid thermal annealing (RTA) were studied. The samples were characterized with cross-sectional transmission electron microscopy (XTEM), including high-resolution electron microscopy (HREM) and far infrared transmittance (FIRT) spectroscopy. The formation of β-FeSi2 nanocrystallites, with various shapes and sizes, in the Si matrix was revealed. The optical constants dispersions of the samples were obtained from the reflectance (R) and transmittance (T) spectra, taken between 0.38 and 1.2 eV. From these dispersions, the energy band diagram of the interface β-FeSi2/Si was determined, and compared to those reported by other authors.
Understanding Passenger Patterns in Public Transit Through Smart Card and Socioeconomic Data: A case study in Rennes, France

Data collected by Automated Fare Collection (AFC) systems are a valuable resource for studying the travel habits of large city inhabitants. In this paper, we present an approach to mining the temporal behavior of the passengers in a public transportation system in order to extract relevant and easily interpretable clusters. Such classification can be useful for several applications. It may help transport operators better know the demand of their customers and propose targeted incentives, services, and tools accordingly. From a city perspective, this may also help redesign and improve existing transportation policies. To achieve this objective, an additional step of analysis is required and the clustering results need to be contextualized. The spatial location of the different types of passengers is then of great interest. We propose a first step in this direction through a rough estimation of the regular passengers' 'residence' location and the analysis of socioeconomic information available at a fine-grained spatial level. The approach is applied on a real dataset from the metropolitan area of Rennes (France) with four weeks of smart card data containing trips made by both bus and subway.
Bradykinin Induces Interleukin‐6 Expression in Astrocytes Through Activation of Nuclear Factor‐κB

Abstract : Bradykinin, a mediator of inflammation, is produced in the brain during trauma and stroke. It is thought to open the blood‐brain barrier, although the mechanism is unclear. We have investigated, therefore, the effect of bradykinin on the expression of interleukin‐6 (IL‐6), a putative modulator of the blood‐brain barrier, in astrocytes. IL‐6 gene transcription was evaluated by transient transfection of the human IL‐6 promoter linked to the luciferase gene. In murine astrocytes, bradykinin stimulated IL‐6 secretion and gene transcription. The effect of bradykinin was blocked by KN‐93, an inhibitor of Ca2+/calmodulin‐dependent protein kinases, and by bisindolyl‐maleimide I, an inhibitor of protein kinase C, suggesting the involvement of these protein kinases. Mutations in the multiple response element and the binding site for nuclear factor‐κB (NF‐κB), but not in other known elements of the IL‐6 promoter, interfered with induction of IL‐6 transcription. The involvement of NF‐κB was supported further by the binding that overexpression of nmIκBα, a stable inhibitor of NF‐κB, inhibited the induction of IL‐6 by bradykinin. Bradykinin activated NF‐κB in primary astrocytes as shown by increased DNA binding of NF‐κB. These data demonstrate that bradykinin stimulates IL‐6 expression through activation of NF‐κB, which may explain several inflammatory effects of bradykinin.
The Relationship Between Tennis Serve Velocity and Select Performance Measures.

The purpose of this study was to determine if there was a relationship between tennis serve speed and isometric mid-thigh pull (IMTP) kinetic variables; countermovement jump height (CMJ Height), shoulder internal and external rotation strength and anthropometric measures in elite adolescent tennis players. Twenty-one elite junior tennis players from the Tennis Australia National Academy were recruited for this study (male, n = 12, female, n = 9). Correlations between the performance variables and peak tennis serve speed were calculated using a Pearson's product-moment correlation coefficient. A significant positive correlation was found between peak serve speed and body height (r = 0.80, p < 0.01), IMTP peak force (r = 0.87, p < 0.01), CMJ Height (r = 0.77, p = < 0.01) and impulse at 300ms (r = 0.71, p = < 0.01). A significant, strong correlation was found between peak serve speed and impulse at 100ms (r = 0.58, p = < 0.01), impulse at 200ms (r = 0.64, p = < 0.01), internal rotation <90 (r = 0.63, p = < 0.01) and external rotation <90 (r = 0.63, p = < 0.01). Due to the significant positive correlations between IMTP variables, CMJ Height and peak serve speed, strength and conditioning coaches with access to a force plate should consider using the isometric mid-thigh pull in order to athletically profile athletes in regards to their strength, power and injury risk.
Structural modelling of global capital asset pricing

The causality patterns in confirmatory factor analysis models for global capital asset pricing have not been extensively studied before. The bulk of factor analytic research concerning asset returns focuses on specific topics, such as the number of relevant factors and their connection to observable economic variables. Most empirical studies of capital assest pricing use securities from a single country. In this study we present evidence on a global arbitrage pricing model, with factors attributable to geographical continents. We demonstrate that the Scandinavian stock markets are interconnected to global return mechanisms in a causal model. We also show that, during the study period, the factorial structure is changing, a possible reason being the integration of the European markets.
Expression of skeletal muscle sodium channel (Nav1.4) or connexin32 prevents reperfusion arrhythmias in murine heart.

AIMS acute myocardial ischaemia induces a decrease in resting membrane potential [which leads to reduction of action potential (AP) V(max)] and intracellular acidification (which closes gap junctions). Both contribute to conduction slowing. We hypothesized that ventricular expression of the skeletal muscle Na(+) channel, Nav1.4 (which activates fully at low membrane potentials), or connexin32 (Cx32, which is less pH-sensitive than connexin43) would support conduction and be antiarrhythmic. We tested this hypothesis in a murine model of ischaemia and reperfusion arrhythmias. METHODS AND RESULTS empty adenovirus (Sham) or adenoviral constructs expressing either SkM1 (gene encoding Nav1.4) or Cx32 genes were injected into the left ventricular wall. Four days later, ventricular tachycardia (VT) occurred during reperfusion following a 5 min coronary occlusion. In Nav1.4- and Cx32-expressing mice, VT incidence and duration were lower than in Sham (P < 0.05). In vitro multisite microelectrode mapping was performed in the superfused right ventricular wall. To simulate ischaemic conditions, [K(+)] in solution was increased to 10 mmol/L and/or pH was decreased to 6.0. Western blots revealed Cx32 and Nav1.4 expression in both ventricles. Nav1.4 APs showed higher V(max) and conduction velocity (CV) than Shams at normal and elevated [K(+)]. Exposure of tissue to acid solution reduced intracellular pH to 6.4. There was no difference in CV between Sham and Cx32 groups in control solution. Acid solution slowed CV in Sham (P < 0.05) but not in Cx32. CONCLUSION Nav1.4 or Cx32 expression preserved normal conduction in murine hearts and decreased the incidence of reperfusion VT.
Enhanced oxidation–dissolution theory of electropolishing

Abstract Electropolishing is the electrolytic metal finishing process currently widely used in several high tech applications such as cardiovascular and orthopaedic body implants, pharmaceutical and semiconductor installations, superconductive niobium cavities, among others. The process provides a very clean, smooth, Beilby layer free, corrosion resistant surface. Currently, almost any metal, alloy and intermetallic compound can be electropolished, but in spite of that, we still do not have a single commonly accepted electropolishing theory. To make it even more complicated, the electropolishing process is constantly modified by addition of other physical agents and/or forces such as a magnetic field – magnetoelectropolishing, ultrasounds, or by changing the existing process parameters such as switching from direct to pulse current. The existing electropolishing theories differ in many ways from each other but possess one common ingredient, namely the viscous layer. The aim of this work is to show that the viscous layer is not an indispensible prerequisite to achieve a satisfactory electropolishing finish in every metal–electrolyte system. A supplement to the most broadly accepted electropolishing solid film theory by Hoar, namely the enhanced oxidation–dissolution equilibrium theory, is proposed.
Influence of attitudes, impulsivity, and parental styles in adolescents’ externalizing behavior

Diverse works have associated externalizing problem behavior with impulsivity, parental styles, and attitudes toward violence. The aim of this study is to analyze the association between these variables and externalizing behavior. A cross-sectional correlational design was used with a sample of 252 adolescents, aged between 12 and 15 years, from the general population. The results obtained indicate a significant association of externalization with high impulsivity, ingrained attitudes toward violence, and inconsistent parental styles, as well as gender and age differences. These results are discussed in relation with the influence of gender stereotypes and their implications in the development of attitudes toward violence.
Extensional rheology of coating suspensions in relation with misting in film coaters

Coating suspensions are submitted to very high strain rates in the transfer nip of film coaters, which leads under certain conditions to misting. The extensional viscosity of coating suspensions is mainly responsible for this major runnability issue. An orifice flowmeter was used for measuring the extensional properties of complex rheology fluids such as coating suspensions. The principle of this flowmeter is based on the relationship between pressure drop and the flow rate of fluid passing through a small orifice. The flowmeter was firstly calibrated in terms of a dimensionless Euler number as a function of the Reynolds number with Newtonian fluids. The corresponding curve was then used to determine the apparent extensional viscosity of coating suspensions. Results of extensional properties of paper coating suspensions are presented and compared to shear viscosity. The Trouton ratio (ratio of extensional to shear viscosity) for some coating suspensions was shown to exceed considerably the theoretical value of 3 expected for Newtonian fluids. The runnability of four coating suspensions was assessed using a pilot coater in terms of the transfer ratio and the coat weight. Results showed that a pronounced strain hardening reduces considerably the amount of misting but the drop size becomes smaller.
Lymphoproliferative Disorders

CIRCULATING VILLOUS LYMPHOCYTES THE LINR BETWEEN 266 INFECTIONS COMPLICATING TREATMENT OF LYMPHOlD MALIGNANCIES WITH FLUDARABUIE. Imelda Bates, George Bedu-Addo', David, Bevan, Tim D.P.Busuttil, RC.CbastyJ. kCopplestone,M.D.Hamon,A.G. Prentice. Demfnrd Hospital,Plymwtb,PU SDH. Rutherford. St George's Hospital, London; Komfo Anokye Teaching Hospital, Kumasi, Ghana 264 RBACTIVE MALARIAL SPLRNOMEGALY AND SPLENIC LWHOMA?