Miracle-dz/UniFAR-FTUs huggingface dataset:
Retinal transplants restore visual responses: trans‐synaptic tracing from visually responsive sites labels transplant neurons

This study aimed to test the hypothesis that visual responses in the superior colliculus (SC) originate from synaptic connections between fetal retinal transplants and degenerating host retinas. Sheets of embryonic day 19 rat retina expressing human placental alkaline phosphatase were transplanted to the subretinal space of 3‐ to 4‐week‐old S334ter‐line‐3 rats with fast retinal degeneration. Several months later, visual responses were recorded from the SC. Attenuated pseudorabies virus that is specifically transferred between neurons at synapses (strains PRV‐152, expressing green fluorescent protein (GFP) or BaBlu, expressing Escherichia coliβ‐galactosidase) was injected into the visually responsive site of the SC. After survival times of 1–2 days, the virus was detected in the retina by immunohistochemistry in combination with different retinal cell markers, such as protein kinase C, recoverin, calcium‐calmodulin‐dependent protein kinase II and glutamine synthetase. Transplanted rats had a mean response threshold of −3.1 log cd/m2 in a small area of the SC corresponding to the location of the graft in the retina. By 30 h after injection into this SC area, the virus traced back to host ganglion cells overlying the transplant and in close proximity to the transplant. By 2 days after injection, extensive virus label was found in the host retina and many cells in the transplant were also labeled. Virus‐labeled cells in the transplant were double labeled for neuronal and glial cell markers. This study provides anatomical evidence that synaptic connections between fetal retinal transplants and host retinas contribute to the visual responses in the SC.
School Effects on Pupil Progress: Research Findings and Policy Implications.

RUTTER, MICHAEL. School Effects on Pupil Progress: Research Findings and Policy Implications. CHILD DEVELOPMENT, 1983, 54, 1-29. Some of the differences in conclusions on whether schooling influences pupil progress have stemmed from the use of difference concepts of school "effects. " These are reviewed in terms of the proportion of the variance accounted for, the reduction of inequality, and the raising of standards. It is argued that multiple indicators of school effectiveness are required; these should include scholastic attainment, classroom behavior, absenteeism, attitudes to learning, continuation in education, employment, and social functioning. The methodological issues inherent in the determination of school effects in raising standards are reviewed, with an emphasis on the need to control for variations in intake and to determine whether the differences among schools in pupil outcome are attributable to measured features of the schools themselves. It is concluded that there are important school effects that probably represent causal influences. The school features that might be responsible for beneficial effects on pupil progress are reviewed in terms of resources and physical plant, size of school and class, organizational structure, composition of student body, degree of academic emphasis, classroom management, discipline and pupil conditions, pupil participation and responsibility, and staff organization. The policy implications that stem from the research findings are considered.
An empirical evaluation of test case filtering techniques based on exercising complex information flows

Some software defects trigger failures only when certain complex information flows occur within the software. Profiling and analyzing such flows therefore provides a potentially important basis for filtering test cases. We report the results of an empirical evaluation of several test case filtering techniques that are based on exercising complex information flows. Both coverage-based and profile-distribution-based filtering techniques are considered. They are compared to filtering techniques based on exercising basic blocks, branches, function calls, and def-use pairs, with respect to their effectiveness for revealing defects.
Insecticidal properties of genetically engineered baculoviruses expressing an insect juvenile hormone esterase gene

Exploring the possibility of enhancing the properties of baculoviruses as biological control agents of insect pests, we tested the effect of expressing an insect gene (jhe) encoding juvenile hormone esterase. Juvenile hormone esterase inactivates juvenile hormone, which regulates the outcome of an insect molt. A cDNA encoding the juvenile hormone esterase of Heliothis virescens was inserted into the genome of Autographa californica nuclear polyhedrosis virus such that the gene was expressed under the control of a strong, modified viral promoter. This virus, however, naturally encodes an ecdysteroid UDP-glucosyltransferase which inactivates ecdysone, the hormone which initiates molting. Since ecdysteroid UDP-glucosyltransferase could mask the effects of jhe expression by blocking molting entirely, jhe-expressing viruses in which the ecdysteroid UDP-glucosyltransferase gene was deleted or disrupted were constructed. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of proteins from infected cells revealed several intracellular proteins and two major secreted proteins which reacted with antibodies to authentic juvenile hormone esterase. Western blot analysis coupled with tunicamycin treatment indicated that differential glycosylation was responsible for the multiple products. Hemolymph of recombinant virus-infected fourth-instar Trichoplusia ni larvae contained levels of juvenile hormone esterase activity 40-fold higher than maximal levels found in uninfected larvae. However, little or no difference in developmental characteristics, weight gain, or time of mortality was observed between insects infected with the jhe-expressing viruses and control viruses.
Costs Associated with Malaria in Pregnancy in the Brazilian Amazon, a Low Endemic Area Where Plasmodium vivax Predominates

Background Information on costs associated with malaria in pregnancy (MiP) in low transmission areas where Plasmodium vivax predominates is so far missing. This study estimates health system and patient costs of MiP in the Brazilian Amazon. Methods/Principal Findings Between January 2011 and March 2012 patient costs for the treatment of MiP were collected through an exit survey at a tertiary referral hospital and at a primary health care centre in the Manaus metropolitan area, Amazonas state. Pregnant and post-partum women diagnosed with malaria were interviewed after an outpatient consultation or at discharge after admission. Seventy-three interviews were included in the analysis. Ninety-six percent of episodes were due to P. vivax and 4% to Plasmodium falciparum. In 2010, the total median costs from the patient perspective were estimated at US $45.91 and US $216.29 for an outpatient consultation and an admission, respectively. When multiple P. vivax infections during the same pregnancy were considered, patient costs increased up to US $335.85, representing the costs of an admission plus an outpatient consultation. Provider direct and overhead cost data were obtained from several sources. The provider cost associated with an outpatient case, which includes several consultations at the tertiary hospital was US $103.51 for a P. vivax malaria episode and US $83.59 for a P. falciparum malaria episode. The cost of an inpatient day and average admission of 3 days was US $118.51 and US $355.53, respectively. Total provider costs for the diagnosis and treatment of all malaria cases reported in pregnant women in Manaus in 2010 (N = 364) were US $17,038.50, of which 92.4% (US$ 15,741.14) due to P. vivax infection. Conclusion Despite being an area of low risk malaria transmission, MiP is responsible for a significant economic burden in Manaus. Especially when multiple infections are considered, costs associated with P. vivax are higher than costs associated with P. falciparum. The information generated may help health policy decisions for the current control and future elimination of malaria in the area.
Service‐learning and the development of empathy in US college students

Purpose – The purpose of this study is to evaluate the influence of a service‐learning experience on the personal development of college students, particularly focusing on the expression of empathy.Design/methodology/approach – Reflective writing papers were evaluated using a rubric with definitions for three types of understanding, as defined by Wiggins and McTighe in 2005, perspective, empathy, and self‐knowledge. The results were analyzed using Fisher's exact test to determine if there were significant differences in the expression of these types of understanding between the service‐learning group and the group that did not do service‐learning.Findings – Students involved in the service‐learning assignment were significantly (p < 0.05) more likely to express empathy in their reflective writing than the students who did not participate in service‐learning. There were no significant differences between the groups in the other two types of understanding.Research limitations/implications – This was a small.
Spending in the American States

The book then discusses Mao, Chu Teh and P'eng Te-huai. The reader must feel compelled to ask, "disproportionate compared to what,? " and how do we know or can we know that the confrontations were traumatic given the state of biographical art on China. ' Pye's analysis depends upon the acceptance of his view of China. If one is compelled to deny or modify those views, what remains may be innovative ideas about psychological constraints in politics, perhaps the necessity to re-think or define assumptions, but not an explanation of Chinese politics.
Tail autotomy and subsequent regeneration alter the mechanics of locomotion in lizards

Animals can undergo significant weight change for a variety of reasons. Autotomy, the voluntary shedding of an appendage in response to a predator stimulus, provides an effective model for measuring the effects of rapid weight change on locomotor behavior and the responses to more gradual weight gain, particularly in lizards capable of both autotomizing and regenerating their tail. Although the general effects of autotomy on locomotor performance are commonly explored, we investigated changes in locomotor mechanics associated with tail loss and long-term regeneration for the first time by measuring morphology, 3D kinematics and ground reaction forces (GRFs) in the leopard gecko Eublepharis macularius. Tail autotomy resulted in a 13% anterior shift in the center of mass (CoM), which only partially recovered after full regeneration of the tail. Although no changes in body or forelimb kinematics were evident, decreases in hindlimb joint angles signify a more sprawled posture following autotomy. Changes in hindlimb GRFs resulted in an increase in weight-specific propulsive force, without a corresponding change in locomotor speed. Hindlimb kinematics and GRFs following autotomy recovered to pre-autotomy values as the tail regenerated. These results suggest an active locomotor response to tail loss that demonstrates the causal relationships between variations in morphology, kinematics and force.
Riffle shuffles with biased cuts

The well-known Gilbert-Shannon-Reeds model for riffle shuffles assumes that the cards are initially cut 'about in half' and then riffled together. We analyze a natural variant where the initial cut is biased. Extending results of Fulman (1998), we show a sharp cutoff in separation and L-infinity distances. This analysis is possible due to the close connection between shuffling and quasisymmetric functions along with some complex analysis of a generating function.
Aprotinin pretreatment diminishes postischemic myocardial contractile dysfunction in dogs.

UNLABELLED We evaluated the effect of aprotinin, administered before the onset of acute regional myocardial ischemia, on reversible contractile dysfunction induced by ischemia and reperfusion in pentobarbital-anesthetized dogs. Animals were randomized to receive either aprotinin 30,000 kallikrein inactivator units (KIU)/kg and 7000 KIU x kg(-1) x hr(-1) (n = 8) or equivalent volumes of 0.9% sodium chloride (n = 7) IV 60 min before a 15-min interruption of circumflex coronary artery blood flow and then reperfusion. There were no intra- or intergroup differences in hemodynamic variables or regional myocardial mechanics (sonomicrometry) before onset of ischemia. Immediately before reperfusion, systolic dysfunction characterized by significantly decreased percent systolic shortening was present in the circumflex coronary artery area of both study groups. After reestablishment of perfusion, aprotinin animals had preserved percent systolic shortening whereas saline animals exhibited regional systolic dysfunction. Regional myocardial contractility as assessed by the slope Mw of the preload recruitable stroke work relation was preserved during reperfusion in animals who received aprotinin but depressed in the control group. We conclude that functional recovery from myocardial ischemia-reperfusion injury at normothermia is improved by IV administration of aprotinin before the onset of acute regional myocardial ischemia in physiologically intact dogs. IMPLICATIONS Administration of clinically relevant doses of aprotinin IV before the onset of regional myocardial ischemia, in contrast to control conditions, preserved regional systolic function and contractility at baseline values after reestablishment of myocardial perfusion in dogs.
Walking the Walk and Talking the Talk

The first aim of this study was to investigate the unique contributions (beyond objective qualifications) of verbal and nonverbal interviewing skills to recruiters’ assessments of applicants. The second aim was to examine whether applicant gender moderates these relationships. Using a sample of 311 recruiter-applicant dyads, we found that interviewing skills explained assessments beyond objective qualifications. Further, nonverbal skills were more strongly related to interview assessments than were verbal skills. Finally, we predicted that rational verbal skills would be more important for females than for males and that nonverbal skills would have a greater impact for males than for females. The former proposition was not supported; the latter was marginally supported.
Vision restoration therapy after brain damage: Subjective improvements of activities of daily life and their relationship to visual field enlargements

Patients with visual field deficits following stroke or neurotrauma can use vision restoration therapy (VRT) to increase their visual field size by about 5° of visual angle.1However, little is known about whether such visual field enlargements are relevant to visually guided activities of daily life. Specifically, we wish to know (1) if VRT affects activities of daily life (ADL) measures, and (2) to what extent any subjective changes correlate with quantitative measures of visual field enlargements. A retrospective analysis was carried out with data of 69 patients that had been interviewed after 6 months of VRT. Patient testimonials were analyzed post hoc and correlated with demographic status and pre/post VRT changes as measured by perimetric testing. As previously described, VRT significantly increased detection ability and most patients (88%) reported subjective benefits in ADL. A correlation analysis of quantitative parameters of visual field enlargements with subjective patient testimonials was perfo.
Deconstructing honeybee vitellogenin: novel 40 kDa fragment assigned to its N terminus

SUMMARY Vitellogenin, an egg-yolk protein precursor common to oviparous animals, is found abundantly in honeybee workers – a caste of helpers that do not usually lay eggs. Instead, honeybee vitellogenin (180 kDa) participates in processes other than reproduction: it influences hormone signaling, food-related behavior, immunity, stress resistance and longevity. The molecular basis of these functions is largely unknown. Here, we establish and compare the molecular properties of vitellogenin from honeybee hemolymph (blood) and abdominal fat body, two compartments that are linked to vitellogenin functions. Our results reveal a novel 40 kDa vitellogenin fragment in abdominal fat body tissue, the main site for vitellogenin synthesis and storage. Using MALDI-TOF combined with MS/MS mass-spectroscopy, we assign the 40 kDa fragment to the N terminus of vitellogenin, whereas a previously observed 150 kDa fragment corresponded to the remainder of the protein. We show that both protein units are N glycosylated and phosphorylated. Focusing on the novel 40 kDa fragment, we present a homology model based on the structure of lamprey lipovitellin that includes a conserved β-barrel-like shape, with a lipophilic cavity in the interior and two insect-specific loops that have not been described before. Our data indicate that the honeybee fat body vitellogenin experiences cleavage unlike hemolymph vitellogenin, a pattern that can suggest a tissue-specific role. Our experiments advance the molecular understanding of vitellogenin, of which the multiple physiological and behavioral effects in honeybees are well established.
Automatic generation of bid phrases for online advertising

One of the most prevalent online advertising methods is textual advertising. To produce a textual ad, an advertiser must craft a short creative (the text of the ad) linking to a landing page, which describes the product or service being promoted. Furthermore, the advertiser must associate the creative to a set of manually chosen bid phrases representing those Web search queries that should trigger the ad. For efficiency, given a landing page, the bid phrases are often chosen first, and then for each bid phrase the creative is produced using a template. Nevertheless, an ad campaign (e.g., for a large retailer) might involve thousands of landing pages and tens or hundreds of thousands of bid phrases, hence the entire process is very laborious. Our study aims towards the automatic construction of online ad campaigns: given a landing page, we propose several algorithmic methods to generate bid phrases suitable for the given input. Such phrases must be both relevant (that is, reflect the content of the page) and well-formed (that is, likely to be used as queries to a Web search engine). To this end, we use a two phase approach. First, candidate bid phrases are generated by a number of methods, including a (mono-lingual) translation model capable of generating phrases contained within the text of the input as well as previously "unseen" phrases. Second, the candidates are ranked in a probabilistic framework using both the translation model, which favors relevant phrases, as well as a bid phrase language model, which favors well-formed phrases. Empirical evaluation based on a real-life corpus of advertiser-created landing pages and associated bid phrases confirms the value of our approach, which successfully re-generates many of the human-crafted bid phrases and performs significantly better than a pure text extraction method.
Surgical Outcome of Soft Tissue Sarcomas of the Adductor Compartment

Purpose. To review outcomes and complications of 25 consecutive patients with soft tissue sarcomas in the adductor compartment. Methods. Records of 11 men and 14 women aged 20 to 83 (mean, 56) years who underwent resection for soft tissue sarcomas in the adductor compartment were reviewed. Two of the patients had undergone inadequate resection of the tumour elsewhere. No patient had metastases. 20 and 2 patients underwent neo-adjuvant and postoperative radiotherapy, respectively. The interval between radiotherapy and surgery was at least 3 weeks. No neo-adjuvant chemotherapy was given. 24 patients underwent limb salvage surgery and one had external hemipelvectomy. 21 patients had direct wound closure; in 4 a microsurgical free flap was used. Results. The overall survival rate was 81% and 72% at 3 and 5 years, respectively, and remained unchanged until the end of follow-up. Four patients died from pulmonary metastases and one died from liver metastases. One patient had local recurrence, and 7 (26%) developed major complications. Five patients underwent revision surgery. Conclusion. Good survival and local control rates can be achieved in patients with soft tissue sarcomas in the adductor compartment using limb salvage and radiotherapy.
Speleothem evidence for temporal–spatial variation in the East Asian Summer Monsoon since the Medieval Warm Period

Published annual‐to‐decadal‐resolution stalagmite δ18O records since AD 900 from six caves (Dongge, Furong, Heshang, Buddha, Shihua and Wanxiang) in China were analyzed to detect temporal and spatial variability of the East Asian Summer Monsoon strength, which strongly affects wet/dry conditions in eastern China. The empirical mode decomposition method was used to obtain trends of the six cave records. After the base trend was determined, δ18O anomalies of each record were computed by subtracting the base trend. Mean δ18O anomaly values of the detrended time series for each cave record were calculated for four periods: (i) Medieval Warm Period (MWP; AD 900–1250): (ii) Little Ice Age phase 1 (LIA‐1; AD 1250–1550); (iii) Little Ice Age phase 2 (LIA‐2; AD 1550–1850); and (iv) modern period (MD; AD 1850–2000). From these anomalies, the temporal and spatial variability of wet/dry conditions has been identified. Positive values of the mean δ18O anomalies indicating drier conditions appeared in the lower Yangtze River Drainage Area and Southeast Coast Area during MD‐1, LIA‐1 and MWP, whereas negative values existed in north, south and Yangtze areas of eastern China during LIA‐2. The results agree with the dryness/wetness index reconstructed by Chinese historic records in general. These results illustrate that wet and dry conditions in different regions of eastern China could be opposite under monsoon influence, so that no single speleothem δ18O record could represent the monsoonal climate in this vast region. Climatic patterns in the monsoonal region can be either a combination of warm/wet and cold/dry or a combination of cold/wet and warm/dry on annual‐to‐centennial scales. A 128‐year periodic cycle exists in all six cave records, whereas 64‐year (possibly a harmonic of 128‐year periodicity) and 42‐year periodicities appear in Shihua, Heshang and Dongge records. These cycles may reflect the influence of solar activity on the East Asian Summer Monsoon. Copyright © 2012 John Wiley & Sons, Ltd.
A cross-curricular approach to ‘learning to learn’ languages: government policy and school practice

This article connects two fields of research: ‘learning to learn’ and school-based teacher development. The context is a cross-curricular project between English and modern languages teachers. Carried out in two London schools, the study aimed to encourage students to transfer common language learning strategies across the two subjects. Findings from interviews with teachers and students highlight the gap between the government's ‘learning to learn’ agenda and the realities of implementing it. A distinction is drawn between providing school-based opportunities for teachers to share generic ‘good practice’ in relation to initiatives such as Assessment for Learning and those where the actual content of lessons crosses subject boundaries. Recent government guidelines appear to mask inherent tensions in the aims and pedagogical approaches of the two languages – tensions exacerbated by the current preoccupation with performance measures. It is suggested that the differences are unlikely to be resolved without a supportive school culture that provides adequate release time for teachers to engage in extensive cross-curricular dialogue.