Miracle-dz/UniFAR-FTUs huggingface dataset:
Does Monitoring Event Changes Improve Comprehension?

During narrative comprehension, reading times increase for changes in time, space, characters, goals, and causation. This study examined the extent to which instructional manipulations modify dimension monitoring during reading and whether this affects comprehension. Sixty-seven participants read three narratives (pretest). Half of the participants (the experimental group) were then instructed to simultaneously monitor changes in time, space, characters, goals, and causation. All participants then read three more narratives (post-test). After reading all texts, participants retold each story and answered comprehension questions. At post-test, the reading times for participants in the experimental group increased for changes in time, space, goals, and causation. Participants in the experimental group remembered more story information containing dimension changes compared with a control group (no instructional manipulation). However, participants in experimental and control groups did not differ in terms of overall memory or performance on comprehension questions. The results indicate that monitoring multiple dimensions simultaneously increases memory for those dimension changes but does not affect overall comprehension.
Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation

Abstract Curcumin is a promising wound healing agent but its clinical application is limited due to hydrophobicity and lack of stability. In this article, we report the results of a study on wound healing efficacy of curcumin conjugated to hyaluronic acid (HA) which is a natural polysaccharide known to influence the healing process. Studies on proliferation, antioxidant activity and scratch wound healing carried out in human keratinocyte cells revealed that HA-conjugated curcumin treatment enhanced cell proliferation, decreased oxidative damage induced by H2O2 and also improved migration of cells in scratch wounds as compared to treatment with native curcumin. HA conjugated curcumin exhibited bactericidal activity in dark and phototoxicity when irradiated with blue light against antibiotic resistant bacteria. Furthermore, wound healing efficacy studied in diabetic mice demonstrated that topical application of the conjugate on wounds led to better healing as compared to treatment with HA-free curcumin and HA alone. These results suggest that HA conjugation is a promising formulation of curcumin for enhancing its healing efficacy.
Crk-Associated Substrate Tyrosine Phosphorylation Sites Are Critical for Invasion and Metastasis of Src-Transformed Cells

Crk-associated substrate (CAS, p130Cas) is a major tyrosine phosphorylated protein in cells transformed by v-crk and v-src oncogenes. We recently reported that reexpression of CAS in CAS-deficient mouse embryo fibroblasts transformed by oncogenic Src promoted an invasive phenotype associated with enhanced cell migration through Matrigel, organization of actin into large podosome ring and belt structures, activation of matrix metalloproteinase-2, and elevated tyrosine phosphorylation of the focal adhesion proteins FAK and paxillin. We have now extended these studies to examine the mechanism by which CAS achieves these changes and to evaluate the potential role for CAS in promoting in vivo tumor growth and metastasis. Whereas the presence or absence of CAS did not alter the primary growth of subcutaneous-injected Src-transformed mouse embryo fibroblasts, CAS expression was required to promote lung metastasis following removal of the primary tumor. The substrate domain YxxP tyrosines, the major sites of CAS phosphorylation by Src that mediate interactions with Crk, were found to be critical for promoting both invasive and metastatic properties of the cells. The ability of CAS to promote Matrigel invasion, formation of large podosome structures, and tyrosine phosphorylation of Src substrates, including FAK, paxillin, and cortactin, was also strictly dependent on the YxxP tyrosines. In contrast, matrix metalloproteinase-2 activation was most dependent on the CAS SH3 domain, whereas the substrate domain YxxP sites also contributed to this property. Thus multiple CAS-mediated signaling events are implicated in promoting invasive and metastatic properties of Src-transformed cells.
Suppression of Sialyl Lewis X Expression and E-selectin-mediated Cell Adhesion in Cultured Human Lymphoid Cells by Transfection of Antisense cDNA of an α1→3 Fucosyltransferase (Fuc-T VII)*

The antisense cDNA approach was used to identify the endogenous fucosyltransferase species responsible for synthesis of the sialyl Lewis X (NeuAcα2→3 Galβ1→4[Fucα1→3]GlcNAcβ1→R) determinant in human lymphoid cells. The cultured human adult T-cell leukemia cell line, ED40515-N, expressed the message of α1→3 fucosyltransferase (Fuc-T) IV and VII, with a low level of the Fuc-T III and VI message, and manifested the sialyl Lewis X as well as Lewis X (Galβ1→4 [Fucα1→3]GlcNAcβ1→R) determinant at the cell surface. Transfection of this cell line with the pRc/CMV vector containing an antisense human Fuc-T VII construct (pRc/CMV/5′FT7AS) resulted in a significant decrease of endogenous Fuc-T VII message and a marked reduction in the cell surface expression of sialyl Lewis X determinant as well as a reduction in the enzymatic activity of α1→3 fucosyltransferase against sialylated type 2 chain substrate. This was accompanied by diminution of cell adhesive activity toward E-selectin on interleukin-1β-treated endothelial cells. These results indicated that the synthesis of the sialyl Lewis X determinants that were functionally active as E-selectin ligands was mainly mediated by Fuc-T VII in these lymphoid cells. On the other hand, the message of Fuc-T IV showed no significant change in the transfectant clones, and the surface expression of the Lewis X antigen as well as the enzymatic activity of α1→3 fucosyltransferase against non-sialylated type 2 chain substrate was well preserved. The clear contrast between the diminished expression of sialyl Lewis X and the conserved manifestation of Lewis X in the transfectant clones suggested that the synthesis of sialyl Lewis X and that of Lewis X are independently regulated by different fucosyltransferases in human lymphoid cells. Fuc-T VII must be involved in the synthesis of sialyl Lewis X, while the synthesis of Lewis X is mediated by an enzyme other than Fuc-T VII, most probably Fuc-T IV.
The Joys and Dangers of Solidarity in Palestine: Prosthetic Engagement in an Age of Reparations

When I come back from Palestine, I probably will have nightmares and constantly feel guilty for not being here, but I can channel that into more work. Coming here is one of the better things I’ve ever done. So when I sound crazy, or if the Israeli military should break with their racist tendency not to injure white people, please pin the reason squarely on the fact that I am in the midst of a genocide that I am also indirectly supporting, and for which my government is largely responsible. —Rachel Corrie, International Solidarity Movement activist (in Stohlman and Aladin 2003, 174)1
The Rise of Vertical Specialization Trade

Manufacturing and vertical specialization (VS) trade, trade in goods that incorporate imported inputs, has grown rapidly since the 1960s. I argue that declining trade costs are an important explanation for these facts. I present a three stage vertical specialization trade model, with raw materials, manufactured parts and final goods sectors. In the simulated model, falling trade costs explain much of the observed growth in overall and VS trade. Manufacturing trade grows twice as fast as overall trade. Raw materials trade was more important in the 1960s when trade costs were high, since their production is more strongly linked to endowments than manufacturing. Therefore, materials will be traded even when trade costs are high. Trade costs have fallen more for manufactured goods over the last 40 years, leading to a rapid expansion of manufactured parts trade relative to materials.
Correlates of Varying Vocal Fold Adduction Deficiencies in Perception and Production: Methodological and Practical Considerations

In this study the voice characteristics of normal male and female speakers are compared to those of two groups of patients with unilateral vocal fold paralysis. In order to enhance phonation, the patients in the first group compensate for the adduction deficiency which results from paralysis. The patients in the second group do not use compensatory strategies. Sustained vowels [i:, a:, u:] were produced by the speakers and scored for roughness, breathiness and hoarseness (RBH) by 8 raters. Although interrater agreement for RBH scores is only moderate on average, these percepts make consistent distinctions between the three speaker groups. Consistent but different distinctions are made between the three speaker groups for male and female speakers. The results show that male and female speakers should not be pooled in experimental studies of the pathological voice. Our results also indicate that female patients with a compensated unilateral vocal fold paralysis cannot be clinically evaluated solely on the basis of perception, because their voices cannot be distinguished from normal, healthy female speakers, despite their physiological impairment. The group distinctions made on the basis of RBH scores are supported by differences in the acoustic parameters which are derived by automatic analysis of the sustained vowels. Despite identical group distinctions for RBH scores and acoustic parameters, the acoustic basis of the percepts is not straightforward. Different acoustic predictors of the percepts were found for male compared to female speakers. Additionally, interrater differences point towards the presence of perceptual trading relations.
No Place like Home: Making the Case for Home Healthcare

In this article, I outline the benefits and advantages provided by home healthcare over more traditional forms of institutional healthcare. These benefits include greater comfort, flexibility, and independence, providing the opportunity for individually tailored care in familiar surroundings in which the prospects of recovery are enhanced. At the same time, however, I caution against the risk that home healthcare alleviates the pressures upon healthcare providers by placing an undue burden of care onto an informal network of family and friends.
Adult Learners in a Research University: Negotiating Undergraduate Student Identity

Adult undergraduate student identities at research extensive universities were uniquely coconstructed, shaped by this selective and competitive youth-oriented cultural context. Drawing upon social constructivist theory, this study explored this coconstruction through positional and relational adult student identities. Positional identities were coconstructed through negotiating academic acceptance in meeting demanding academic challenges and through facing otherness as a mature adult. These adults also viewed their positional identity based in an evolving sense of agency to academically succeed through goal oriented efforts, as well as through their adult maturity and life experiences. These adults articulated relational identities predominantly based in faculty’s tacit or explicit academic acceptance of them in one of four types of relationships. This study suggests that the adult undergraduate student identity is multi-layered, multi-sourced, evolving, and at times, paradoxical in beliefs of self, position, relationships, and learning contexts within the research extensive university setting.
Privacy Preserving for Continuous Query in Location Based Services

Location-based services (LBSs) have become a popular and important way to provide real-time information and guidance. The abuse of mobile users' location data, which may violate their sensitive and private personal information, is one of the major challenges faced by LBS. On the other hand, the query launched by mobile users should not be linked to them even if they are required to expose their location information to attain some services. However, many location based systems (e.g., mobile social networks, store finders) are lacking of users' private preserving consideration. In this paper, we focuse-focus on the issues related to query linking privacy. Particularly, we aim to preserve mobile users' privacy in location based mobile systems where their location information may be available, furthermore, while facing attacks, the sensitive data of a specific mobile user launching the query should not be disclosed to an adversary. We present a new query linking privacy preserving algorithm (V-DCA) for continuous LBS by taking the user's velocity and acceleration similarity into consideration. The consecutive generated cloaked sets are used to create the new cloaked region, which decreases the complexity of the algorithm while fulfilling the privacy requirement. The simulation results show that V-DCA can preserve mobile user's privacy as well as provide better Quality of Service (QoS).
Are daughters of alcoholics more likely to marry alcoholics?

This study evaluates the relationship between having an alcoholic (i.e., alcohol-dependent) parent and the presence of a spouse with a similar diagnosis. Data relating to 708 men and 708 women, the parents of the questionnaire respondents, revealed that even after controlling for the increased rate of alcohol-dependent spouses among alcoholics, assortative mating appears to be associated with positive family histories of alcoholism. Within this sample, nonalcoholic daughters of alcoholics were more than twice as likely to marry an alcoholic as nonalcoholic daughters of nonalcoholics, irrespective of the alcoholic parent's gender. In contrast, in the same sample daughters of alcoholics did not demonstrate a higher rate for having a spouse with another of the more common psychiatric syndromes, a major depressive episode. In this sample, sons of alcoholics did not demonstrate an increased rate for marrying an alcoholic when compared to sons of nonalcoholics.
Mindfulness as psychological dimension: Concepts and applications

Mindfulness has been discovered as a psychologically relevant dimension within the last 25 to 30 years. As mindfulness-based psychological interventions are increasingly perceived as being beneficial, they are more and more integrated into different areas of applied psychology, ranging from health care to staff development. However, the theoretical foundations of the mindfulness construct are ambiguous and require further clarification of operational definitions. The article reviews several developments in this area, takes a critical look at existing operational definitions, their translation into mindfulness self-report scales and their validity. It then provides an outlook on emerging developments and critical aspects, discussing the usefulness of separating mindfulness from outcomes resulting from mindfulness. Finally, suggestions are offered as to how this area could be developed to realise the potential many see in integrating mindfulness-based interventions into applied psychology.
Obligatory Adaptation of Saccade Gains Oculomotor and Stimulus Procedures

We tested the hypothesis that saccade gains adapt to minimize error between the visual target and the saccade endpoint of every saccade we make even when the errors on sequential saccades are not directionally consistent. We utilized a state-space model that estimated the degree to which saccade gains were modified by the magnitude and direction of errors made on the previous trial. Importantly, to show that learning did not depend on the accumulation of directionally consistent errors, we fit the model to saccades made to targets that were displaced in a random direction during the saccade, thereby inducing errors with directions that were not sequentially the same. Saccade gains clearly adapted on a trial-by-trial basis despite that the perturbations were random, and the average amount of learning per trial was of similar magnitude as that found in a constant displacement of the target. These results indicate that saccade adaptation is a rapid and obligatory process that does not require conscious awareness. Saccades are ballistic eye movements that shift the point of gaze to a new location that is the goal of visual exploration. They are highly accurate despite being too rapid (ϳ20 ms for small saccades) to be influenced by visual feedback (retinal processing time: ϳ20 –30 ms). Therefore the trajectory of the saccade is programmed prior to its initiation. Within the oculomotor system, the motor programs issued given the position of the visual target on the retina remain accurate in the face of fatigue, injury and aging. Such plasticity emerges through motor learning mechanisms that continually adapt the system to new sensorimotor transformations. Saccade adaptation, as it is called, can be studied in the laboratory by slightly displacing the visual target while the sac-cade is in flight. Following the saccade, the system perceives an error or mismatch between the position of gaze and the visual target. This error induces new motor learning. Since people are effectively blind while a saccade is in flight, subjects are unaware of the shift but nevertheless do adapt the gain of saccades to match the displaced target over time (McLaughlin 1967). Subjects are presented with blocks of trials where the target is consistently displaced and adaptation follows a characteristic profile depending on whether the target was displaced to a greater (forward-stepped) or lesser (back-stepped) eccentricity. The gain changes slowly and exponentially, reaching its maximum by 30 – 60 trials Straube et al. 1997) for …
Brambuk living cultural centre

The article examines the production of tourist space in relation to Brambuk, an Aboriginal cultural centre in Victoria, Australia. In doing so, it draws on Tim Edensor’s discussion of heterogeneous and enclavic spaces, and the narratives of staff and visitors at the cultural centre. The article demonstrates the positive outcomes of heterogeneous space and the limitations of enclavic space for indigenous people seeking to represent themselves within the tourist domain. This exploration produces critical commentary about a range of subjects, including Aboriginal involvement in cultural tourism and visitor responses to Aboriginal cultural centres, both of which are underresearched fields of inquiry. In addition, the significance of indigenous ownership to the representation of Aboriginality in the tourist domain is noted.
Transients in Low-Voltage Supply Networks

For nearly 28000 transients, appearing at 40 measuring places during a total measuring time of about 3400 h on low-voltage supply networks in industrial and nonindustrial areas, time-domain parameters were determined. Of about one-third of the transient disturbances, a Fourier transform yielded frequency-domain data. After a description of the automated measuring system (AMS), results of measurements are presented. A statistical evaluation of several time-and frequency-domain transient parameters proved to be possible. In additional analyses, parameters are derived which are of interest in electro-magnetic-disturbance calculations and conducted-susceptibility tests.
Children's Test Anxiety and Family Interaction Patterns

The relationship between family interaction and children's test and trait anxiety was studied among 152 parent couples, and their children (aged 11-12 years). The results reveal a relationship between children's test and trait anxiety and the following patterns of perceived family interaction: communication, encouragement of personal growth, and system maintenance. Discrepancies between family members' perceptions (father and mother, father and child) were also found. Anxiety levels were linked more to children's perceptions of family variables than to parents' reports. Children's scores for four of the five family variables were lower than those of their parents.
The Effect of Stimulus Intensity and Carrier Frequency on Auditory Middle- and Long-Latency Evoked Potentials Using a Steady-State-Response Approach.

PURPOSE The purpose of this study was to measure magnitude changes of auditory steady-state responses (ASSRs) and respective transient middle- and long-latency responses as a function of stimulus intensity and carrier frequency. The literature lacks clear consensus, including relationship to loudness. METHOD A cohort of 48 adults with normal hearing was examined from a companion study (Tlumak, Durrant, & Delgado, 2015) on effects of aging. ASSRs were elicited by repeated tone-burst stimuli presented at rates of 40 and 0.75 Hz at 3 frequencies and 5 levels of stimulus intensity. The design also permitted scrutiny of any gender bias to the results. RESULTS Similar to derived transient response findings, ASSR magnitude (harmonic sum) systematically increased with intensity. Input-output function only at 0.75 Hz approximated a log-log linear function. However, slopes fell well below that of doubling of loudness per 10 dB SPL. Results failed to demonstrate significance as a function of carrier frequency and gender for both repetition rates. CONCLUSION Effects of stimulus intensity, carrier frequency, and gender on ASSRs were similar to those of their transient counterparts. Findings remain disappointing for objective loudness estimation. Results suggest only a clear linkage to the long-latency response and the 0.75-Hz magnitude but require careful consideration of limitations/underlying mechanisms when measuring loudness-related effects.
'War, Guns and Cool, Tough Things': Interrogating single-sex classes as a strategy for engaging boys in English

In this paper an investigation is undertaken into the impact and effects, on both boys and girls, of implementing single-sex classes--but particularly as a strategy for engaging boys in the English classroom at one particular Catholic coeducational school in Perth, Western Australia. Semi-structured interviews with seven English teachers at this school, where the strategy was implemented, were used both to analyse teachers' perceptions of single-sex classes in the coeducational context and to gain some insight into their pedagogical approaches. The study found that particular assumptions and knowledges about gender informed specific pedagogical approaches adopted by the teachers in single-sex English classes. These assumptions and knowledges and the way they informed the pedagogical practices of the teachers, even in the same school, varied radically. It is concluded that single-sex classes as a strategy per se do not necessarily produce enhanced social and educational outcomes for students. Rather, as indicated in the research, there needs to be more attention directed to the particular effects of pedagogy and the normalising assumptions about gender that inform the implementation of curriculum in both single-sex and coeducational classes.