Miracle-dz/UniFAR-FTUs huggingface dataset:
Proposed re‐dating of the European ice core chronology by seven years prior to the 7th century AD

Progress in the study of past climate change requires integration of historical documentation, tree‐ring data and ice‐core chemistry. Larsen et al. (2008) re‐evaluate volcanic acid signals in the Dye‐3, GRIP and NGRIP ice cores and identify large eruptions at 529 ± 2 and 533–534 ± 2; the latter claimed to cause the ‘dry fog’ of 536–537 and environmental consequences to 550; this conflicts with previous suggestions of a two stage environmental event; one in 536, the second c.540. Understanding the full range of natural hazards requires critical evaluation of the happenings in the mid‐6th century. This paper will show that 4 spaced tree‐ring responses to extreme environmental conditions in the 6th century can be used to re‐locate 4 key ice‐acid dates. Moving the ice‐core chronology forward 7 years places two large volcanoes in 536 and 541 explaining the extended duration of the 536–550 effects and anchoring the ice chronology.
Different Anthocyanin Profiles of the Skin and the Pulp of Yan73 (Muscat Hamburg × Alicante Bouschet) Grape Berries

Yan73 is a “teinturier” red wine variety cultivated in China and used in winemaking to strengthen red wine color. Here, the anthocyanin profile in both the skin and pulp of this grape variety was analyzed by HPLC-MS. The results showed that 18 anthocyanins were detected in both the skin and the pulp, and pelargonidin-3-O-glucoside, an anthocyanin compound hardly detected in most other Vitis vinifera berries, was found. However, the contents of individual anthocyanins in the skin and the pulp were significantly different. Compared with the skin, the pulp exhibited much lower ratio of 3’,5’-substituted to 3’-substituted anthocyanins and much higher ratio of methoxylation of anthocyanin B-ring to non methoxylation, and with regard to the aromatic acylated and aliphatic acylated anthocyanins, both their contents in the skin are higher than in the pulp. The findings will provide some new insight for the tissue-specific expression and regulation of the genes involving in anthocyanin biosynthesis in grape berries.
Cardiovascular Disease and Cognitive Decline in Postmenopausal Women: Results From the Women's Health Initiative Memory Study

Background Data on cardiovascular diseases (CVD) and cognitive decline are conflicting. Our objective was to investigate if CVD is associated with an increased risk for cognitive decline and to examine whether hypertension, diabetes, or adiposity modify the effect of CVD on cognitive functioning. Methods and Results Prospective follow‐up of 6455 cognitively intact, postmenopausal women aged 65 to 79 years old enrolled in the Women's Health Initiative Memory Study (WHIMS). CVD was determined by self‐report. For cognitive decline, we assessed the incidence of mild cognitive impairment (MCI) or probable dementia (PD) via modified mini‐mental state examination (3 MS) score, neurocognitive, and neuropsychiatric examinations. The median follow‐up was 8.4 years. Women with CVD tended to be at increased risk for cognitive decline compared with those free of CVD (hazard ratio [HR], 1.29; 95% CI: 1.00, 1.67). Women with myocardial infarction or other vascular disease were at highest risk (HR, 2.10; 95% CI: 1.40, 3.15 or HR, 1.97; 95% CI: 1.34, 2.87). Angina pectoris was moderately associated with cognitive decline (HR 1.45; 95% CI: 1.05, 2.01) whereas no significant relationships were found for atrial fibrillation or heart failure. Hypertension and diabetes increased the risk for cognitive decline in women without CVD. Diabetes tended to elevate the risk for MCI/PD in women with CVD. No significant trend was seen for adiposity. Conclusions CVD is associated with cognitive decline in elderly postmenopausal women. Hypertension and diabetes, but not adiposity, are associated with a higher risk for cognitive decline. More research is warranted on the potential of CVD prevention for preserving cognitive functioning.
The site of action and active form of local anesthetics. I. Theory and pH experiments with tertiary compounds.

In an attempt to determine the active form and the site of action of tertiary amine local anesthetics, the blocking potency of two lidocaine derivatives, 6211 ( pKa 6.3) and 6603 (pKa 9.8), was compared when they were applied either outside or inside the squid axon membrane at different pH values. Changes in external pH between 7.0 and 9.0 and in internal pH between 7.0 and 8.0 had no effect on the action potential with control experiments. When applied externally, 6211 exhibited the same blocking effect at external pH 7.0 and 9.0. When applied internally, however, it blocked more strongly at internal pH 7.0 than at pH 8.0. When applied externally, 6603 blocked more strongly at external pH 9.0 than at 7.0, whereas, when applied internally, it showed the same blocking potency at internal pH 7.0 and 8.0. The logarithm of the dose needed to block the action potential by 50% (ED50) was plotted as a function of pH on the well documented assumption that only the uncharged form is freely permeable through the nerve membrane. If one assumes that the active form of local anesthetics is either 1) internally or externally present uncharged form, 2) externally present charged form, or 3) internally present charged form, only the theoretical ED50-pH curves for the internally present charged form perfectly fit the experimental results. The blocking potency was also plotted against concentrations of the above three possible active forms, and the resultant dose-response curves are compatible with the concept of the internally present charged form being active. In support of this, the blocking potency of 6211 or 6603 applied externally at a constant pH was decreased by an increase in the pH of internal medium. The blocking potency of 6211 or 6603 applied internally at the constant pH was not affected by external pH change. On the assumption that the cytoplasm pH partially or completely follows the external pH change, depending on various experimental conditions such as the fiber diameter and the availability of diffusion barrier, most of the existing data in the literature concerning the effect of pH change on the local anesthetic potency can be accounted for by the present model. it is concluded that the tertiary amine local anesthetics penetrate the nerve membrane in uncharged forms and block the action potential from inside the membrane in charged forms.
Characteristic Face: A Key Indicator for Direct Diagnosis of 22q11.2 Deletions in Chinese Velocardiofacial Syndrome Patients

Velocardiofacial syndrome (VCFS) is a disease in human with an expansive phenotypic spectrum and diverse genetic mechanisms mainly associated with copy number variations (CNVs) on 22q11.2 or other chromosomes. However, the correlations between CNVs and phenotypes remain ambiguous. This study aims to analyze the types and sizes of CNVs in VCFS patients, to define whether correlations exist between CNVs and clinical manifestations in Chinese VCFS patients. In total, 55 clinically suspected Chinese VCFS patients and 100 normal controls were detected by multiplex ligation-dependent probe amplification (MLPA). The data from MLPA and all the detailed clinical features of the objects were documented and analyzed. A total of 44 patients (80.0%) were diagnosed with CNVs on 22q11.2. Among them, 43 (78.2%) presented with 22q11.2 heterozygous deletions, of whom 40 (93.0%) had typical 3-Mb deletion, and 3 (7.0%) exhibited proximal 1.5-Mb deletion; no patient was found with atypical deletion on 22q11.2. One patient (1.8%) presented with a 3-Mb duplication mapping to the typical 3-Mb region on 22q11.2, while none of the chromosomal abnormalities in the MLPA kit were found in the other 11 patients and 100 normal controls. All the 43 patients with 22q11.2 deletions displayed characteristic face and palatal anomalies; 37 of them (86.0%) had cognitive or behavioral disorders, and 23 (53.5%) suffered from immune deficiencies; 10 patients (23.3%) manifested congenital heart diseases. Interestingly, all patients with the characteristic face had 22q11.2 heterozygous deletions, but no difference in phenotypic spectrum was observed between 3-Mb and 1.5-Mb deletions. Our data suggest that the characteristic face can be used as a key indicator for direct diagnosis of 22q11.2 deletions in Chinese VCFS patients.
Interleukin-32 induces the differentiation of monocytes into macrophage-like cells

After emigration from the bone marrow to the peripheral blood, monocytes enter tissues and differentiate into macrophages, the prototype scavenger of the immune system. By ingesting and killing microorganisms and removing cellular debris, macrophages also process antigens as a first step in mounting a specific immune response. IL-32 is a cytokine inducing proinflammatory cytokines and chemokines via p38-MAPK and NF-κB. In the present study, we demonstrate that IL-32 induces differentiation of human blood monocytes as well as THP-1 leukemic cells into macrophage-like cells with functional phagocytic activity for live bacteria. Muramyl dipepide (MDP), the ligand for the intracellular nuclear oligomerization domain (NOD) 2 receptor, has no effect on differentiation alone but augments the monocyte-to-macrophage differentiation by IL-32. Unexpectedly, IL-32 reversed GM-CSF/IL-4-induced dendritic cell differentiation to macrophage-like cells. Whereas the induction of TNFα, IL-1β, and IL-6 by IL-32 is mediated by p38-MAPK, IL-32-induced monocyte-to-macrophage differentiation is mediated through nonapoptotic, caspase-3-dependent mechanisms. Thus, IL-32 not only contributes to host responses through the induction of proinflammatory cytokines but also directly affects specific immunity by differentiating monocytes into macrophage-like cells.
Petrology of spinel granulites from Araku, Eastern Ghats, India, and a petrogenetic grid for sapphirine-free rocks in the system FMAS

Spinel-quartz-cordierite and spinel-quartz are found as relic prograde assemblages in Fe-rich granulites from the Araku area, Eastern Ghats belt, India. Subsequent reactions produced orthopyroxene + sillimanite in the former association and garnet + sillimanite in the latter. The first reaction is univariant in the FMAS system, but is trivariant in the present case because of the presence of Zn and Fe3+ in spinel. The second reaction also has high variance because of Zn and Fe3+, but also because of the presence of Ca in garnet. Thermobarometry shows that the metamorphic conditions were approximately 950° C and 8.5 kbar and the fo2 was near the NNO buffer. In Fe-rich bulk compositions and low-P-high-T conditions of metamorphism, two of the univariant reactions around the invariant point [Sa], namely (Sa, Hy) and (Sa, Cd), change topology due to reverse partitioning of Fe-Mg between coexisting garnet and spinel. An alternative partial petrogenetic grid in the system FMAS is constructed for such conditions and is applied satisfactorily to several sapphirine-free spinel granulites. It is shown that bulk composition (XFe and Zn) exerts greater control on the stability of spinel + quartz than fo2. The effect of the presence of Zn and Fe3+ in spinel on the proposed grid is evaluated. Reaction textures in the Araku spinel granulites can be explained from the petrogenetic grid as due to near-isobaric cooling.
Stable solutions of a scalar conservation law for particle-size segregation in dense granular avalanches

Dense, dry granular avalanches are very efficient at sorting the larger particles towards the free surface of the flow, and finer grains towards the base, through the combined processes of kinetic sieving and squeeze expulsion. This generates an inversely graded particle-size distribution, which is fundamental to a variety of pattern formation mechanisms, as well as subtle size-mobility feedback effects, leading to the formation of coarse-grained lateral levees that create channels in geophysical flows, enhancing their run-out. In this paper we investigate some of the properties of a recent model [Gray, J. M. N. T. & Thornton, A. R. (2005) A theory for particle size segregation in shallow granular free-surface flows. Proc. R. Soc. 461, 1447–1473]; [Thornton, A. R. , Gray, J. M. N. T. & Hogg, A. J. (2006) A three-phase mixture theory for particle size segregation in shallow granular free-surface flows. J. Fluid. Mech. 550, 1–25] for the segregation of particles of two sizes but the same density in a shear flow typical of shallow avalanches. The model is a scalar conservation law in space and time, for the volume fraction of smaller particles, with non-constant coefficients depending on depth within the avalanche. It is proved that for steady flow from an inlet, complete segregation occurs beyond a certain finite distance down the slope, no matter what the mixture at the inlet. In time-dependent flow, dynamic shock waves can develop; they are interfaces separating different mixes of particles. Shock waves are shown to be stable if and only if there is a greater concentration of large particles above the interface than below. Constructions with shocks and rarefaction waves are demonstrated on a pair of physically relevant initial boundary value problems, in which a region of all small particles is penetrated from the inlet by either a uniform mixture of particles or by a layer of small particles over a layer of large particles. In both cases, and under a linear shear flow, solutions are constructed for all time and shown to have similar structure for all choices of parameters.
Capturing Word Choice Patterns with LDA for Fake Review Detection in Sentiment Analysis

The usefulness of user-generated online reviews is hampered by fake reviews, often produced by clandestinely sponsored reviewers. Detecting fake reviews is a difficult task even for laypeople, and this has also been the case for previous automatic detection approaches, which have only had a limited success. Earlier studies showed that people who tell lies or write deceptive reviews tend to select words unnaturally. We propose a novel approach to detecting fake reviews by applying a topic modeling method based on Latent Dirichlet Allocation (LDA). A unique contribution of this paper is to explicate some latent aspects of fake and truthful reviews by means of "topics" that are not necessarily subject areas but related to the word choice patterns reflecting behavioral and linguistic characteristics of the fake review writers. We constructed a labeled dataset based on Yelp and demonstrated that the proposed approach helps identifying unique aspects of fake and truthful reviews, which has a potential to improving the performance of the fake review detection task. The experimental result shows that our proposed method yields better performance than that of state-of-the-art methods for small size categories in our dataset.
Vascular proliferations of the breast

Vascular proliferations of the breast are uncommon but potentially diagnostically challenging lesions. Clinically apparent processes are more likely to be malignant; however, a range of benign entities which must be differentiated from angiosarcoma also exists. This review discusses first, breast lesions of apparent vascular origin, then benign and histologically bland perilobular, cavernous and capillary haemangiomas. Subsequently, more diagnostically challenging, atypical haemangiomas, papillary endothelial hyperplasia, angiomatosis and angiolymphoid hyperplasia with eosinophilia (epithelioid haemangioma) are considered. In addition, lesions with low‐grade malignant potential such as haemangiopericytomas and epithelioid haemangioendotheliomas may rarely present in the breast. However, primary angiosarcomas and radiation‐associated vascular lesions are reviewed in depth, as these entities are of greatest clinical and pathological significance.
PRODUCTION OF THE AFRICAN CATFISH (CLARIAS GARIEPINUS) I. GROWTH, MORTALITY AND YIELD SOUTH OF THE ZAMBEZI

SUMMARY Clarias gariepinus were sampled from eight water bodies in southern Africa between 1973 and 1975. Aging results indicate a similar growth pattern for most areas with a near linear age-length relationship. Between year growth compensation was found to be present in Lakes Kyle and Mcllwaine in Zimbabwe, and to a lesser extent in Hardap Dam, South West Africa, but not present in Lake Kariba, Zimbabwe. The fishable biomass of catfish from Lake Kyle is estimated between 0,61 to 1,14 kg ha−1. Fishable biomass for all species is in the range 12,1 to 22,7 kg ha−1. The instantaneous growth rate was found to be between 0,20 and 0,25 for fully recruited age groups. The fishing mortality appears to be in the range of 0,4 for Lakes Kyle and Kariba and 0,5 for Lake McIlwaine. All of these levels are above the yield per recruit F0, 1 levels of 0,27, 0,28 and 0,24 respectively which would normally indicate that each of these stocks is being overexploited. However, this does not appear to be the case in these trop.
Modulated wave packets and envelope solitary structures in complex plasmas

A theoretical study is presented of the nonlinear amplitude modulation of waves propagating in unmagnetized plasmas contaminated by charged dust particles. Distinct well-known dusty plasma modes are explicitly considered, namely, the dust-acoustic wave, the dust-ion acoustic wave, and transverse dust-lattice waves. Using a multiple-scale technique, a nonlinear Schrodinger-type equation is derived, describing the evolution of the wave amplitude. A stability analysis reveals the possibility for modulational instability to occur, possibly leading to the formation of different types of envelope-localized excitations (solitary waves), under conditions which depend on the wave dispersion laws and intrinsic dusty plasma parameters.
Comparison of Population-Based Association Study Methods Correcting for Population Stratification

Population stratification can cause spurious associations in population–based association studies. Several statistical methods have been proposed to reduce the impact of population stratification on population–based association studies. We simulated a set of stratified populations based on the real haplotype data from the HapMap ENCODE project, and compared the relative power, type I error rates, accuracy and positive prediction value of four prevailing population–based association study methods: traditional case-control tests, structured association (SA), genomic control (GC) and principal components analysis (PCA) under various population stratification levels. Additionally, we evaluated the effects of sample sizes and frequencies of disease susceptible allele on the performance of the four analytical methods in the presence of population stratification. We found that the performance of PCA was very stable under various scenarios. Our comparison results suggest that SA and PCA have comparable performance, if sufficient ancestral informative markers are used in SA analysis. GC appeared to be strongly conservative in significantly stratified populations. It may be better to apply GC in the stratified populations with low stratification level. Our study intends to provide a practical guideline for researchers to select proper study methods and make appropriate inference of the results in population-based association studies.
Associations of housing mobility interventions for children in high-poverty neighborhoods with subsequent mental disorders during adolescence.

IMPORTANCE Youth in high-poverty neighborhoods have high rates of emotional problems. Understanding neighborhood influences on mental health is crucial for designing neighborhood-level interventions. OBJECTIVE To perform an exploratory analysis of associations between housing mobility interventions for children in high-poverty neighborhoods and subsequent mental disorders during adolescence. DESIGN, SETTING, AND PARTICIPANTS The Moving to Opportunity Demonstration from 1994 to 1998 randomized 4604 volunteer public housing families with 3689 children in high-poverty neighborhoods into 1 of 2 housing mobility intervention groups (a low-poverty voucher group vs a traditional voucher group) or a control group. The low-poverty voucher group (n=1430) received vouchers to move to low-poverty neighborhoods with enhanced mobility counseling. The traditional voucher group (n=1081) received geographically unrestricted vouchers. Controls (n=1178) received no intervention. Follow-up evaluation was performed 10 to 15 years later (June 2008-April 2010) with participants aged 13 to 19 years (0-8 years at randomization). Response rates were 86.9% to 92.9%. MAIN OUTCOMES AND MEASURES Presence of mental disorders from the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) within the past 12 months, including major depressive disorder, panic disorder, posttraumatic stress disorder (PTSD), oppositional-defiant disorder, intermittent explosive disorder, and conduct disorder, as assessed post hoc with a validated diagnostic interview. RESULTS Of the 3689 adolescents randomized, 2872 were interviewed (1407 boys and 1465 girls). Compared with the control group, boys in the low-poverty voucher group had significantly increased rates of major depression (7.1% vs 3.5%; odds ratio (OR), 2.2 [95% CI, 1.2-3.9]), PTSD (6.2% vs 1.9%; OR, 3.4 [95% CI, 1.6-7.4]), and conduct disorder (6.4% vs 2.1%; OR, 3.1 [95% CI, 1.7-5.8]). Boys in the traditional voucher group had increased rates of PTSD compared with the control group (4.9% vs 1.9%, OR, 2.7 [95% CI, 1.2-5.8]). However, compared with the control group, girls in the traditional voucher group had decreased rates of major depression (6.5% vs 10.9%; OR, 0.6 [95% CI, 0.3-0.9]) and conduct disorder (0.3% vs 2.9%; OR, 0.1 [95% CI, 0.0-0.4]). CONCLUSIONS AND RELEVANCE Interventions to encourage moving out of high-poverty neighborhoods were associated with increased rates of depression, PTSD, and conduct disorder among boys and reduced rates of depression and conduct disorder among girls. Better understanding of interactions among individual, family, and neighborhood risk factors is needed to guide future public housing policy changes.
Is mutation an appropriate tool for testing experiments? [software testing]

The empirical assessment of test techniques plays an important role in software testing research. One common practice is to instrument faults, either manually or by using mutation operators. The latter allows the systematic, repeatable seeding of large numbers of faults; however, we do not know whether empirical results obtained this way lead to valid, representative conclusions. This paper investigates this important question based on a number of programs with comprehensive pools of test cases and known faults. It is concluded that, based on the data available thus far, the use of mutation operators is yielding trustworthy results (generated mutants are similar to real faults). Mutants appear however to be different from hand-seeded faults that seem to be harder to detect than real faults.