Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinicopathological Characteristics and Prognosis of Non-Small Cell Lung Cancer Patients Associated with a Family History of Lung Cancer

Introduction: Clinicopathological characteristics and prognosis of non-small cell lung cancer (NSCLC) patients with a family history of lung cancer (FHLC) have not been well established. Methods: Clinical records of patients with NSCLC treated at our institute from 1982 to 2010 were reviewed with special reference to family history of lung cancer and clinicopathological factors including patient's outcome. Univariate analyses of the factors between the groups of FHLC and non-FHLC were performed using unpaired two-tailed t tests or the chi-square test. The Cox proportional hazards model was used to evaluate the hazard ratio of death. Results: Of the 1013 NSCLC patients, 124 (12.2%) had a FHLC of whom 119 (96%) were the first-degree relatives. The frequency of early stages of lung cancer was high in both groups of FHLC and non-FHLC patients. Patients with FHLC had a significantly higher frequency of early pathological stages and a prepomderance of adenocarcinoma, and a hazard ratio of death of 0.870 (95% confidence interval: 0.599-1.263, p value: 0.465) compared with the non-FHLC patients. Conclusions: NSCLC patients with FHLC could be characterized by early pathological stages and preponderance of adenocarcinoma, however they were not at a decreased hazard ratio of death. These findings emphasize the importance of early detection of lung cancer and employment of less invasive therapeutic interventions.
Searching for Planets in the Hyades. IV. Differential Abundance Analysis of Hyades Dwarfs

We present a differential abundance analysis of Hyades F–K dwarfs in search for evidence of stellar enrichment from accreted hydrogen-deficient disk material. Metallicities and relative abundance ratios of several species have been determined. We derive a cluster mean [Fe/H] = 0.13 ± 0.01. Two stars show abundances ∼0.2 dex larger than the cluster mean. In addition, one star, which was added by a recent study as a cluster member, shows significantly lower abundances than the cluster mean. These three stars have questionable membership characteristics. The remaining stars in the survey have an rms of 0.04 dex in the differential [Fe/H] values. The Hyades cluster members have apparently not been significantly chemically enriched. The abundance ratios of Si, Ti, Na, Mg, Ca, and Zn with respect to Fe are in their solar proportions.
Sensitivity analysis of rare-event splitting applied to cascading blackout models

Splitting is a technique that can be used to improve the efficiency in simulating rare events. The basic idea is to create separate copies (splits) of the simulation whenever it gets close to the rare event. To implement splitting, several decisions must be made - for example, choosing a level function, choosing the number of simulation runs for each level, etc. This paper analyzes the sensitivity of the variance of the rare-event estimator to several parameters used within the splitting framework. We specifically consider a two-level fixed-effort variation of splitting for which analytic results can be derived. Results are applied to a simple model of cascading blackouts. The results illustrate that a good choice for the locations of levels may be more important than a good choice for the importance function for these types of problems.
LIKWID: A Lightweight Performance-Oriented Tool Suite for x86 Multicore Environments

Exploiting the performance of today's processors requires intimate knowledge of the microarchitecture as well as an awareness of the ever-growing complexity in thread and cache topology. LIKWID is a set of command-line utilities that addresses four key problems: Probing the thread and cache topology of a shared-memory node, enforcing thread-core affinity on a program, measuring performance counter metrics, and toggling hardware prefetchers. An API for using the performance counting features from user code is also included. We clearly state the differences to the widely used PAPI interface. To demonstrate the capabilities of the tool set we show the influence of thread pinning on performance using the well-known OpenMP STREAM triad benchmark, and use the affinity and hardware counter tools to study the performance of a stencil code specifically optimized to utilize shared caches on multicore chips.
Fibroblast-adapted human CMV vaccines elicit predominantly conventional CD8 T cell responses in humans

Cytomegalovirus (CMV)-based vaccines have shown remarkable efficacy in the rhesus macaque model of acquired immune deficiency syndrome, enabling 50% of vaccinated monkeys to clear a subsequent virulent simian immunodeficiency virus challenge. The protective vaccine elicited unconventional CD8 T cell responses that were entirely restricted by MHC II or the nonclassical MHC I molecule, MHC-E. These unconventional responses were only elicited by a fibroblast-adapted rhesus CMV vector with limited tissue tropism; a repaired vector with normal tropism elicited conventional responses. Testing whether these unusual protective CD8 T responses could be elicited in humans requires vaccinating human subjects with a fibroblast-adapted mutant of human CMV (HCMV). In this study, we describe the CD8 T cell responses of human subjects vaccinated with two fibroblast-adapted HCMV vaccines. Most responses were identified as conventional classically MHC I restricted, and we found no evidence for MHC II or HLA-E restriction. These results indicate that fibroblast adaptation alone is unlikely to explain the unconventional responses observed in macaques.
Liquid crystalline cellulose-based nematogels

An ordered network of cellulose nanofibers infiltrated with a liquid crystal forms an electrically tunable nematogel. Physical properties of composite materials can be pre-engineered by controlling their structure and composition at the mesoscale. However, approaches to achieving this are limited and rarely scalable. We introduce a new breed of self-assembled nematogels formed by an orientationally ordered network of thin cellulose nanofibers infiltrated with a thermotropic nematic fluid. The interplay between orientational ordering within the nematic network and that of the small-molecule liquid crystal around it yields a composite with highly tunable optical properties. By means of combining experimental characterization and modeling, we demonstrate submillisecond electric switching of transparency and facile responses of the composite to temperature changes. Finally, we discuss a host of potential technological uses of these self-assembled nematogel composites, ranging from smart and privacy windows to novel flexible displays.
A double white dwarf with a paradoxical origin

We present Hubble Space Telescope UV spectra of the 4.6-h-period double white dwarf SDSS J125733.63+542850.5. Combined with Sloan Digital Sky Survey optical data, these reveal that the massive white dwarf (secondary) has an effective temperature T2 = 13 030 ± 70 ± 150 K and a surface gravity log g2 = 8.73 ± 0.05 ± 0.05 (statistical and systematic uncertainties, respectively), leading to a mass of M2 = 1.06 M⊙. The temperature of the extremely low-mass white dwarf (primary) is substantially lower at T1 = 6400 ± 37 ± 50 K, while its surface gravity is poorly constrained by the data. The relative flux contribution of the two white dwarfs across the spectrum provides a radius ratio of R1/R2 ≃ 4.2, which, together with evolutionary models, allows us to calculate the cooling ages. The secondary massive white dwarf has a cooling age of ∼1 Gyr, while that of the primary low-mass white dwarf is likely to be much longer, possibly ≳5 Gyr, depending on its mass and the strength of chemical diffusion. These results unexpectedly suggest that the low-mass white dwarf formed long before the massive white dwarf, a puzzling discovery which poses a paradox for binary evolution.
Brentuximab vedotin for treatment of relapsed or refractory malignant lymphoma: results of a systematic review and meta-analysis of prospective studies

Background Recently, brentuximab vedotin has become a promising therapeutic approach for CD30-positive hematological malignancies, but its role in other relapsed or refractory malignant lymphoma needs to be proven. Brentuximab vedotin was demonstrated effective, but no study has summarized the concrete effect of brentuximab vedotin in malignant lymphoma. To truly know the role of brentuximab vedotin, we performed a systematic review of the literature and a meta-analysis of all known prospective trials, to assess the value of brentuximab vedotin for patients with relapsed and refractory malignant lymphoma. Methods and materials This was a systematic review of publications indexed in the PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and ISI Web of Knowledge performed on February 10, 2015. Six studies, including 302 patients were identified. Meta-analyses were carried out to calculate the objective response rate (ORR), complete response rate (CRR), and partial response rate (PRR) of brentuximab vedotin for malignant lymphoma. Results In patients with malignant lymphoma, ORR was 0.61, CRR was 0.38, and PRR was 0.51. High heterogeneity between studies was observed, and funnel plots were not symmetrical, which means that publication bias existed. Brentuximab vedotin was generally well-tolerated by patients reported in the included studies; adverse effects also occurred, but they were considered manageable. Conclusion Our analysis revealed a promising benefit of brentuximab vedotin in the treatment of relapsed and refractory malignant lymphoma. Larger sample of randomized controlled clinical trials are needed in the future.
The Performance and Robustness of Interest-Rate Rules in Models of the Euro Area

In this paper, we examine the performance and robustness of optimized interest-rate rules in four models of the euro area that differ considerably in terms of size, degree of aggregation, relevance of forward-looking behavioral elements, and adherence to microfoundations. Our findings are broadly consistent with results documented for models of the U.S. economy: backward-looking models require relatively more aggressive policies with, at most, moderate inertia; rules that are optimized for such models tend to perform reasonably well in forward-looking models, while the reverse is not necessarily true; and, hence, the operating characteristics of robust rules (i.e., rules that perform satisfactorily in all models) are heavily weighted towards those required by backward-looking models.
Prevention of Cerebral Infarction in the Monkey by Omental Transposition to the Brain

The intact omentum of 13 monkeys was lengthened, placed subcutaneously, and laid on the left cerebral hemisphere prior to occluding the left middle cerebral artery. Two of these 13 monkeys developed left cerebral infarct and a right hemiparesis. Nine other monkeyshad their left middle cerebral artery occluded without omental protection. All of these 9 developed a left cerebral infarct and 8 of them a right hemiparesis. Intact omentum may prevent a cerebral infarction when placed on the brain prior to MCA occlusion.
Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI

Angiogenesis plays a major role in tumor growth and metastasis, with tumor perfusion regarded as a marker for angiogenesis. To evaluate antiangiogenic treatment response in vivo, we investigated arterial spin labeling (ASL) magnetic resonance imaging (MRI) to measure tumor perfusion quantitatively. Chronic and 24‐h acute treatment responses to bevacizumab were assessed by ASL and dynamic‐contrast‐enhanced (DCE) MRI in the A498 xenograft mouse model. After the MRI, tumor vasculature was assessed by CD34 staining. After 39 days of chronic treatment, tumor perfusion decreased to 44.8 ± 16.1 mL/100 g/min (P < 0.05), compared to 92.6 ± 42.9 mL/100 g/min in the control group. In the acute treatment study, tumor perfusion in the treated group decreased from 107.2 ± 32.7 to 73.7 ± 27.8 mL/100 g/min (P < 0.01; two‐way analysis of variance), as well as compared with control group post dosing. A significant reduction in vessel density and vessel size was observed after the chronic treatment, while only vessel size was reduced 24 h after acute treatment. The tumor perfusion correlated with vessel size (r = 0.66; P < 0.005) after chronic, but not after acute treatment. The results from DCE‐MRI also detected a significant change between treated and control groups in both chronic and acute treatment studies, but not between 0 and 24 h in the acute treatment group. These results indicate that tumor perfusion measured by MRI can detect early vascular responses to antiangiogenic treatment. With its noninvasive and quantitative nature, ASL MRI would be valuable for longitudinal assessment of tumor perfusion and in translation from animal models to human.
Twisted endoscopy and reducibility of induced representations for $p$-adic groups

1. Introduction. This is the first in a series of papers in which we study the reducibility of representations induced from discrete series representations of the Levi factors ofmaximal parabolic subgroups of p-adic groups on the unitary axis. The problem is equivalent to determining certain local Langlands L-functions which are of arithmetic significance by themselves. One of the main aims of this paper is to interpret our results in the direction of the parametrization problem by means of the theory of twisted endoscopy for which our method seems to be very suitable. When the representation is supercuspidal, we also study the reducibility of the induced representations off the unitary axis. Let F be a p-adic field of characteristic zero. Fix a positive integer n > 1 and let G be either of the groups SP2n, S02n or S02n+l. In all three cases there is a conjugacy class of maximal parabolic subgroups which has GL,, as its Levi factor. Let P MN be the standard parabolic subgroup ofG in this conjugacy class. Then M GL,,. Let tr be a discrete series representation of M GLn(F) and, given s C, let I(s, tr) be the representation of G G(F) induced from tr (R) Idet( )ls. Let I(tr) I(0, tr).
Comparative in vitro activities of piperacillin-tazobactam and ticarcillin-clavulanate

The in vitro activities of ticarcillin, piperacillin, clavulanic acid, tazobactam, ticarcillin-clavulanate, and piperacillin-tazobactam against 819 bacterial isolates were compared. The two beta-lactamase inhibitors, clavulanic acid and tazobactam, had little useful antibacterial activity but enhanced the activities of the penicillins against beta-lactamase-producing strains of Haemophilus influenzae, Branhamella catarrhalis, and methicillin-susceptible Staphylococcus aureus; all strains were susceptible to both combinations. Both enzyme inhibitors also enhanced the activities of the penicillins against most strains of Escherichia coli, Klebsiella spp. , Citrobacter diversus, Proteus spp. , Providencia spp. , and Bacteroides spp. and against occasional strains of Citrobacter freundii, Enterobacter spp. , and Serratia marcescens. Clavulanic acid frequently enhanced the activity of ticarcillin against Xanthomonas maltophilia, and tazobactam frequently enhanced the activity of piperacillin against Morganella morganii. Enhancement was observed primarily with strains relatively resistant to the penicillins. In general, clavulanic acid was more effective than tazobactam in enhancing penicillin activity against Klebsiella spp. , C. diversus, X. maltophilia, and Bacteroides spp. , whereas tazobactam was more effective against Escherichia coli and Proteeae. There was little or no enhancement of activity against Enterococcus faecalis, Aeromonas hydrophila, Pseudomonas aeruginosa, Pseudomonas cepacia, or Acinetobacter anitratus. Clavulanic acid occasionally antagonized the activity of ticarcillin against ticarcillin-susceptible members of the family Enterobacteriaceae, but those strains were still considered susceptible to the combination. Tazobactam never antagonized the activity of piperacillin. In a direct comparison of the activities of ticarcillin-clavulanate and piperacillin-tazobactam, the two were equally active against H. influenzae, B. catarrhalis, and S. aureus; the latter was more active against E. faecalis. For relatively susceptible strains of members of the family Enterobacteriaceae, neither combination was predictably more active than the other, but relatively resistant strains were generally more susceptible to piperacillin-tazobactam. Piperacillin-tazobactam was more active than ticarcillin-clavulanate against A. hydrophila, P. aeruginosa, and P. cepacia, similar in activity against A. anitratus, and less active against X. maltophilia and Bacteroides spp.
Conservative management versus surgery for small vestibular schwannomas

Conclusion A high rate of deterioration in hearing function and the loss of patient compliance during conservative management should be taken into account when considering hearing preservation strategies for patients with vestibular schwannoma (VS). Objective To compare conservative management with surgery for solitary small VS. Material and methods Among 693 patients followed up for VS between 1991 and 2002, 114 (16%) intracanalicular VSs (stage 1) and 302 (44%) VSs measuring <15 mm in the cerebellopontine angle (stage 2) were included in this study. Initially, surgery was performed in 305 (73%) cases (50 stage 1, 255 stage 2) and 111 (27%) were managed conservatively (64 stage 1, 54 stage 2) by means of annual MRI scans and audiometry. Conservative management was chosen in patients aged >60 years and in those who refused surgery. In this subgroup, the mean follow-up period was 33 months (range 6–111 months). Results In the conservative management group, 47% of VSs showed significant growth, 47% were stable and 6% showed regression. Seventeen patients (15%) were operated on secondarily for tumour growth and 1 (1%) was irradiated for tumour growth and because surgery was contraindicated. Deterioration of hearing function by ≥1 class was observed in 56% of cases, 34% of patients were initially in hearing class D and only 10% showed stable hearing function. Of the conservative management group, 17% were lost during follow-up. After surgery, grade 1 or 2 facial function was obtained in 86% of cases. Following hearing preservation attempts (n=137), 54% of patients were in hearing classes A–C.
An experimental study on the fuel reduction potential of heavy duty vehicle platooning

Vehicle platooning has become important for the vehicle industry. Yet conclusive results with respect to the fuel reduction possibilities of platooning remain unclear. The focus in this study is the fuel reduction that heavy duty vehicle platooning enables and the analysis with respect to the influence of a commercial adaptive cruise control on the fuel consumption. Experimental results show that by using preview information of the road ahead from the lead vehicle, the adaptive cruise controller can reduce the fuel consumption. A study is undertaken for various masses of the lead vehicle. The results show that the best choice with respect to a heavier or lighter lead vehicle depends on the desired time gap. A maximum fuel reduction of 4.7–7.7% depending on the time gap, at a set speed of 70 km/h, can be obtained with two identical trucks. If the lead vehicle is 10 t lighter a corresponding 3.8–7.4% fuel reduction can be obtained depending on the time gap. Similarly if the lead vehicle is 10 t heavier a 4.3–6.9% fuel reduction can be obtained. All results indicate that a maximum fuel reduction can be achieved at a short relative distance, due to both air drag reduction and suitable control.
A tale of two mice: A trans-Holocene record of Peromyscus nesodytes and Peromyscus maniculatus at Daisy Cave, San Miguel Island, California

Rats and mice are among the most successful mammals on earth, with some of these species thriving in and around human settlements or areas disturbed by human activities. Here, we present morphological, taphonomic, and chronological data on two mice (Peromyscus nesodytes [extinct] and P. maniculatus [extant]) from a trans-Holocene sequence at Daisy Cave, San Miguel Island, California. We explore the colonization history of each species, species abundance through time, taphonomic history, and the causes and timing of the extinction of P. nesodytes. P. maniculatus were probably introduced by humans to San Miguel Island ~11,000 years ago, 1000 years earlier than previous estimates, and P. nesodytes does not occur in Daisy Cave deposits after ~8000 years ago, some 7000 years earlier than reported at adjacent Cave of the Chimneys. Island P. maniculatus form a distinct morphological group from all other North American subspecies. These data highlight the importance of morphological analyses of archaeological and subfossil rodent specimens for understanding the evolution and natural history of island endemic species and their interactions with humans.
Elevated Serum Levels of NSE and S-100β Correlate with Increased Risk of Acute Cerebral Infarction in Asian Populations

Background We investigated the clinical value of serum levels of neuron-specific enolase (NSE) and human soluble protein-100β (S-100β) in acute cerebral infarction (ACI) patients. Material/Methods A literature search of electronic databases identified relevant case-control studies that examined the correlations between NSE and S-100β serum levels, and ACI. The retrieved studies were screened based on our strict inclusion and exclusion criteria, and high-quality studies were subsequently selected for meta-analysis. STATA software (Version 12.0, Stata Corporation, College Station, TX, USA) was utilized for statistical analysis. Results A total of 13 case-control studies, containing 911 ACI patients and 686 healthy controls, were enrolled in this meta-analysis. The results of the meta-analysis showed that serum levels of NSE and S-100β in ACI patients were significantly higher than the control group. Subgroup analysis based on ethnicity revealed that the serum levels of NSE and S-100β in ACI patients were significantly higher than the control group in Asian population. In Caucasian population, the serum levels of NSE in case group was significantly higher than the control group, but no significant differences in serum levels of S-100β were observed between ACI patients and the control group. Conclusions Based on our results, we conclude that serum levels of NSE and S-100β strongly correlate with ACI in Asian population, and may be important clinical markers for diagnosis and treatment of ACI.