Miracle-dz/UniFAR-FTUs huggingface dataset:
CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models

Hematologically derived tumors make up ∼10% of all newly diagnosed cancer cases in the United States. Of these, the non-Hodgkin lymphoma (NHL) designation describes a diverse group of cancers that collectively rank among the top 10 most commonly diagnosed cancers worldwide. Although long-term survival trends are improving, there remains a significant unmet clinical need for treatments to help patients with relapsed or refractory disease, one cause of which is drug efflux through upregulation of xenobiotic pumps, such as MDR1. CD22 is a clinically validated target for the treatment of NHL, but no anti-CD22 agents have yet been approved for this indication. Recent approval of an anti-CD22 antibody–drug conjugate (ADC) for the treatment of relapsed/refractory ALL supports the rationale for targeting this protein. An opportunity exists for a next-generation anti-CD22 antibody–drug conjugate (ADC) to address unmet medical needs in the relapsed/refractory NHL population. We describe a site-specifically conjugated antibody–drug conjugate, made using aldehyde tag technology, targeted against CD22 and bearing a noncleavable maytansine payload that is resistant to MDR1-mediated efflux. The construct was efficacious against CD22+ NHL xenografts and could be repeatedly dosed in cynomolgus monkeys at 60 mg/kg with no observed significantly adverse effects. Exposure to total ADC at these doses (as assessed by AUC0-inf) indicated that the exposure needed to achieve efficacy was below tolerable limits. Together, the data suggest that this drug has the potential to be used effectively in patients with CD22+ tumors that have developed MDR1-related resistance to prior therapies. Mol Cancer Ther; 17(1); 161–8. ©2017 AACR.
Teachers and computers : Teachers' computer usage and the relationship between computers and the role of the teacher, as described in international research

This doctoral dissertation includes two main works and a comprehensive summary:Jedeskog, G. 1996: Larare vid datorn. Sju hogstadielarares undervisning med datorer 1984-1994. (Teachers at Computers. Seven upper compulsory school teachers´ teaching with computers in 1984-1994.) SkapandeVetande, Linkopings universitet. ISBN 91-7871-664-0. (in Swedish)Jedeskog, G. 2000: Ny i kl@ssen. Forhallandet mellan lararroll och datoranvandning beskrivet i internationell forskning. (New in Cl@ss. The relationship between computers and the role of the teacher, as described ininternational research.) ISBN 91-646-1473-5. (in Swedish)The comprehensive summary is written in English: Teachers and Computers, Uppsala University, Department of Educatiom 48 pp. ISBN 91-506-1439-8.The first work was presented and defended in 1996. The second work, New in Cl@ss, is summarised here:For about fifteen years now, there have been computers in the schools meant for instructional use. The focus of this study is to describe and analyse how the relationship between computers and the role of the teacher has been treated in international scholarly literature, 1988-1998. The empirical study has two aims:To outline and analyse the contents of the texts with regard to what is happening to the role of the teacher, i.e.the work and deeds of the teacher, in a time when computers and IT are being introduced and used, or not used,in teaching.To outline and analyse, using the selected texts, how the research field of computers and the role of the teacheris now being moulded.The analysis of the texts is based on three theoretical platforms; House's innovation theory, the actors-networktheory and a micropolitical perspective. In these theories the importance of power, participation and conflict isemphasised.Results show that three variants of the role of the teacher in connection with computer usage stand out: theteacher as a link between the pupil and the computer, as a technician and delegating routine work to thecomputer.The role of the computer can be observed as a rival, as an 'alarm clock', as a mediator of contacts, as anobstacle to contacts and as a replacement for the school.An analysis of the research area shows that it is possible to distinguish four categories of texts; texts with noreference to earlier research and texts with references to research on processes of innovation and reform, onknowledge and learning and on relationship between school and society.
Probabilistic CFG with Latent Annotations

This paper defines a generative probabilistic model of parse trees, which we call PCFG-LA. This model is an extension of PCFG in which non-terminal symbols are augmented with latent variables. Fine-grained CFG rules are automatically induced from a parsed corpus by training a PCFG-LA model using an EM-algorithm. Because exact parsing with a PCFG-LA is NP-hard, several approximations are described and empirically compared. In experiments using the Penn WSJ corpus, our automatically trained model gave a performance of 86.6% (F1, sentences ≤ 40 words), which is comparable to that of an unlexicalized PCFG parser created using extensive manual feature selection.
Development of a New Serological Test for Serotyping Haemophilus parasuis Isolates and Determination of Their Prevalence in North America

ABSTRACT Haemophilus parasuis causes polyserositis in swine. Fifteen serovars have been characterized by immunodiffusion test, but many field strains are not typeable. Isolates (n = 300) of H. parasuis from animals in North America were serotyped by a new indirect hemagglutination test. The test was rapid and effective for serotyping of H. parasuis, and serovars 4, 5, 13, and 7 were the most prevalent serotypes.
Functional role of the basal ganglia in the planning and execution of actions

Recent studies of functional brain imaging have shown the involvement of the basal ganglia in executive processes such as planning and set‐shifting. However, the specific contributions of the striatum in those processes remain unknown. This study aimed to test the hypothesis that the caudate nucleus is primarily involved in the preparation of a novel action and not in set‐shifting per se.
Effect of the Nutrient intakes on Psychosocial Stress

This research was designed to see the relationship among nutrient intake, food intake frequency and psychosocial stress in ordinary life. The subjects were 190 males and 263 females of university students in urban areas. There were significant correlations between nutrient intake and stress value, and between food intake frequency and stress value. In male, the more they consumed energy, protein and carbohydrate, the higher they had stress in several categories. But in female the results were reversed. Their stress values were lower when they have consumed protein source food frequently. And in general, stress values of female were higher than those of male. From these results, we conclude that nutrient intake tends to be decresed with increase stress in less stressful condition, but to be increased in more stressful condition.
Antimicrobial susceptibility patterns of enterobacteriaceae isolated from HIV-infected patients in Kinshasa

Introduction People infected by Human Immunodeficiency Virus (HIV) are susceptible to develop severe bacterial infections. We set out to determine the frequency and the sensitivity to antibiotics of enterobaceriaceae isolated from urine and feces of HIV-infected persons. Methods Urine and feces samples were collected from HIV-infected patients of the Centre de Traitement Ambulatoire de Kabinda (CTA/Kabinda, Kinshasa) and analyzed at the Reference National Laboratory for HIV/AIDS and Sexually Transmitted Infections. The isolated enterobacteriaceae strains were identified by conventional microbiological methods. Antibiotic sensitivity pattern was carried out by disc diffusion method. Results The following bacteria pathogens were isolated: Escherichia coli, Klebsiella, Enterobacter, Proteus, and Providencia. Most species were sensitive to cefotaxim, ceftriaxon, and gentamicin and resistant to chloramphenicol, cotrimoxazole, tetracycline, and norfloxacin. Conclusion The results of the present study show that the most frequently bacteria isolated were Esherichia coli and cefotaxim, ceftriaxon, and gentamicin were the most active antibiotics.
On dance and difference: bodies, movement and experience in Khoesān trance-dancing – perceptions of a ‘raver’

Book synopsis: How do people learn and experience their culture? How do people make a living? What does it mean to be in a family? How do we make sense of peoples’ beliefs and ritual practices? In exploring questions such as these, this cultural anthropology reader focuses on contemporary global concerns and includes a significant number of articles by authors from outside the United States. A dynamic development in the fourth edition is the inclusion of “Anthropology and Public Debate” sections, in which opposing anthropological arguments on current hot topics are featured. In addition, “Doing Fieldwork” essays consider the nature and dilemmas of fieldwork, the changing status of the field, the nature of anthropological learning in the field, and ethical issues and dilemmas.
A Scalable Tree-Based Approach for Joint Object and Pose Recognition

Recognizing possibly thousands of objects is a crucial capability for an autonomous agent to understand and interact with everyday environments. Practical object recognition comes in multiple forms: Is this a coffee mug (category recognition). Is this Alice's coffee mug? (instance recognition). Is the mug with the handle facing left or right? (pose recognition). We present a scalable framework, Object-Pose Tree, which efficiently organizes data into a semantically structured tree. The tree structure enables both scalable training and testing, allowing us to solve recognition over thousands of object poses in near real-time. Moreover, by simultaneously optimizing all three tasks, our approach outperforms standard nearest neighbor and 1-vs-all classifications, with large improvements on pose recognition. We evaluate the proposed technique on a dataset of 300 household objects collected using a Kinect-style 3D camera. Experiments demonstrate that our system achieves robust and efficient object category, instance, and pose recognition on challenging everyday objects.
In vivo activation and functions of the protease factor XII

Summary Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. The biochemistry of the contact system in vitro is well understood; however, its in vivo functions are just beginning to emerge. The current review concentrates on activators and functions of the FXII-driven contact system in vivo. Elucidating its physiologic activities offers the exciting opportunity to develop strategies for the safe interference with both thrombotic and inflammatory diseases.
What Contributes to Talent Development in Eminent Women?

Abstract The lives of ten eminent Australian women across seven talent domains were explored for factors that contributed to the development of their talent. Nine themes and related sub-themes emerged that were linked to the Model of Adult Female Talent Development (MAFTD) developed by Noble, Subotnik & Arnold (1996, 1999). Results provided support for this MAFTD as an appropriate representation or framework of talent development for gifted females. In addition, these themes expand and elucidate elements of this MAFTD thereby adding a depth of knowledge based on the lives of eminent Australian women. This is the first study to investigate the talent development of Australian women from a feminist perspective.
Enablers and barriers experienced by grandparents who become primary caregivers of grandchildren: An occupational perspective

Aim: The aim of this review was to identify current issues affecting grandparents who are raising their grandchildren in Australia. Method: The study systematically reviewed twelve studies that evaluated supports for grandparents. The Checklist Analysis of Research for Systematic Review and the Quantitative and Qualitative Checklist were used to evaluate the studies. Findings: Five support issues affecting grandparent-headed families were evidenced in the literature as being of priority. These include stress, intergenerational conflict, community support, legal and financial aspects, policies and service frameworks. Conclusions: The paucity of research implies that further funding for large-scale research is required. Implications for informal primary carers of grandchildren are that the lack of legal status and the sustained burden of care will continue to negatively impact upon the grandparents’ well-being. Recommendation: Further research to identify priorities and develop intervention strategies supported by policy development is required to enhance the health and well-being of grandparent carers and their grandchildren.
Bacterial oxidation of the polycyclic aromatic hydrocarbons acenaphthene and acenaphthylene

A Beijerinckia sp. and a mutant strain, Beijerinckia sp. strain B8/36, were shown to cooxidize the polycyclic aromatic hydrocarbons acenaphthene and acenaphthylene. Both organisms oxidized acenaphthene to the same spectrum of metabolites, which included 1-acenaphthenol, 1-acenaphthenone, 1,2-acenaphthenediol, acenaphthenequinone, and a compound that was tentatively identified as 1,2-dihydroxyacenaphthylene. In contrast, acenaphthylene was oxidized to acenaphthenequinone and the compound tentatively identified as 1,2-dihydroxyacenaphthylene by the wild-type strain of Beijerinckia. Both of these products were also formed when the organism was incubated with synthetic cis-1,2-acenaphthenediol. A metabolite identified as cis-1,2-acenaphthenediol was formed from acenaphthylene by the mutant Beijerinckia sp. strain B8/36. Cell extracts prepared from the wild-type Beijerinckia strain contain a constitutive pyridine nucleotide-dependent dehydrogenase which can oxidize 1-acenaphthenol and 9-fluorenol. The results indicate that although acenaphthene and acenaphthylene are both oxidized to acenaphthenequinone, the pathways leading to the formation of this end product are different.
Impact on ART initiation of point-of-care CD4 testing at HIV diagnosis among HIV-positive youth in Khayelitsha, South Africa

Despite the rapid expansion of antiretroviral therapy (ART) programmes in developing countries, pre‐treatment losses from care remain a challenge to improving access to treatment. Youth and adolescents have been identified as a particularly vulnerable group, at greater risk of loss from both pre‐ART and ART care. Point‐of‐care (POC) CD4 testing has shown promising results in improving linkage to ART care. In Khayelitsha township, South Africa, POC CD4 testing was implemented at a clinic designated for youth aged 12–25 years. We assessed whether there was an associated reduction in attrition between HIV testing, assessment for eligibility and ART initiation.
Has the Behavior of Inflation and Long-Term Inflation Expectations Changed?

From 1975 to 1980, inflation in core (nonfood and nonenergy) consumer prices rose sharply as crude oil prices more than tripled. Yet, as crude oil prices quadrupled from late 2001 to 2007, core consumer price inflation remained essentially flat. Some observers have attributed the stability of consumer price inflation in the more recent episode to the influence of long-term inflation expectations. While inflation expectations rose significantly in the second half of the 1970s, they remained largely unchanged from 2001 through 2007. The increased stability of inflation and long-term expectations raises the possibility that the behavior of both variables has fundamentally changed. ; Recent discussion has focused on two possible forms of change: the influence of long-run expectations on inflation and the anchoring of inflation and expectations. A third possible source of change is smaller shocks to inflation, expectations, and other macroeconomic variables. Any of these changes in the behavior of inflation and long-term inflation expectations could have important implications for monetary policy. ; Clark and Nakata find some evidence that the dynamics of inflation and long-term inflation expectations have changed modestly. In particular, compared to 20 or more years ago, inflation and expectations appear to be slightly better anchored: Unexpected increases in inflation die out slightly faster and produce less of an increase in long-term expectations. However, the reduced volatility of inflation and expectations is largely due to smaller shocks.
Rationality and the Reflective Mind

Preface CHAPTER I: Dual-Process Theory and the Great Rationality Debate The Great Rationality Debate Individual Differences in the Great Rationality Debate Dual Process Theory: The Current State of Play Properties of Type 1 and Type 2 Processing Dual-Process Theory and Human Goals: Implications for the Rationality Debate The Rest of This Book: Complications in Dual Process Theory and Their Implications for the Concepts of Rationality and Intelligence CHAPTER II: Differentiating the Algorithmic Mind and the Reflective Mind Unpacking Type 2 Functioning Using Individual Differences Cognitive Ability and Thinking Dispositions Partition the Algorithmic and the Reflective Mind Intelligence Tests and Critical Thinking Tests Partition the Algorithmic from the Reflective Mind Thinking Dispositions as Independent Predictors of Rational Thought CHAPTER III: The Key Functions of the Reflective Mind and the Algorithmic Mind that Support Human Rationality So-Called "Executive Functioning" Measures Tap the Algorithmic Mind and Not the Reflective Mind CHAPTER IV: The Tri-Process Model and Serial Associative Cognition The Cognitive Miser and Focal Bias Converging Evidence in the Dual Process Literature CHAPTER V: The Master Rationality Motive and the Origins of the Nonautonomous Mind Metarepresentation and Higher-Order Preferences What Motivates the Search for Rational Integration? The Master Rationality Motive as a Psychological Construct Evolutionary Origins of the Master Rational Motive and Type 2 Processing CHAPTER VI: A Taxonomy of Rational Thinking Problems (with Richard F. West) Dual-Process Theory and Knowledge Structures The Preliminary Taxonomy Heuristics and Biases Tasks in Terms of the Taxonomy Multiply-Determined Problems of Rational Thought Missing Input from the Autonomous Mind CHAPTER VII: Intelligence as a Predictor of Performance on Heuristics and Biases Tasks (with Richard F. West) Intelligence and Classic Heuristics and Biases Effects Belief Bias and Myside Bias Why Thinking Biases Do and Do Not Associate with Cognitive Ability Cognitive Decoupling, Mindware Gaps, and Override Detection in Heuristics and Biases Tasks CHAPTER VIII: Rationality and Intelligence: Empirical and Theoretical Relationships and Implications for the Great Rationality Debate Intelligence and Rationality Associations in Terms of the Taxonomy Summary of the Relationships Individual Differences, the Reflective Mind, and the Great Rationality Debate Skepticism About Mindware-Caused Irrationalities CHAPTER IX: The Social Implications of Separating the Concepts of Intelligence and Rationality Broad Versus Narrow Concepts of Intelligence Intelligence Imperialism Intelligence Misidentified as Adaptation and the Deification of Intelligence Strategies for Cutting Intelligence Down to Size Society's Selection Mechanisms CHAPTER X: The Assessment of Rational Thought (with Richard F. West and Maggie E. Toplak) A Framework for the Assessment of Rational Thinking Operationalizing the Components of Rational Thought The Future of Research on Individual Differences in Rational Thought References Figures and Tables
Pension Funds' Performance in Strongly Regulated Industries in Central Europe: Evidence from Poland and Hungary

This paper presents an analysis of pension funds' performance in Poland and Hungary, two Central European countries characterized by strong regulation of their private pension fund industries. Thus, the paper extends the literature, which has so far mostly focused on the performance of pension fund industries facing no or limited regulation. We find that the performance of pension funds in the two studied countries differs. While we do not find convincing evidence of outperformance by Polish pension funds, we find strong evidence of underperformance by Hungarian pension funds. The results are robust to time variation. The paper considers possible explanations for these findings. The results of the paper should be of interest to policymakers seeking to achieve optimal performance of pension systems and to academics researching the area of pension funds.
Benefits of Physical Activity on Depression and Functional Quality of Life During Treatment for Breast Cancer: Psychosocial Mechanisms.

of a thesis at the University of Miami. Women who are post surgery for breast cancer (BCa) experience distressing side effects that negatively influence Quality of Life (QoL). Physical activity (PA) following a BCa diagnosis is associated with decreased mortality, reduced recurrence, increased functional capacity, less fatigue, and may improve depression and QoL. Furthermore, evidence suggests that a combined PA and psychotherapy intervention may reduce physically and emotionally distressing side effects associated with diagnosis and treatment. The purpose of the study is to examine relationships among PA, fatigue, clinician-rated depression, depressed mood, and QoL in women after undergoing surgery for BCa and to assess the continuity of these relationships as they move through adjuvant treatment. In addition, the study investigates whether fatigue is an underlying psychosocial mechanism accounting for the effects of PA on study outcomes. Finally, given prior evidence that participation in a Cognitive-Behavioral Stress Management (CBSM) intervention was associated with reduced fatigue, the study assesses whether women who were physically active showed less fatigue above and beyond the effects of CBSM. Women (N=240) with non-metastatic stage 0-III BCa were recruited 2-10 weeks post-surgery and randomized to either a CBSM intervention group or a psycho-educational control group. Physical activity, fatigue, functional QoL, rated depression, and depressed mood were assessed at the baseline and 3-month post intervention time points. Structural equation modeling was used to test hypotheses. At baseline, results revealed that greater PA was associated with less fatigue-related daily interference (FRDI), and that less FRDI was associated with greater functional QoL, lower rated depression, and less depressed mood. Furthermore, lower FRDI was a pathway by which greater PA was associated with greater functional QoL, less rated depression, and less depressed mood. These relationships were similar at the 3-month post intervention time point and when difference scores were used in the model. Finally, PA contributed significantly to the change in FRDI above and beyond the effects of participation in CBSM. A combined PA and CBSM intervention may be effective in reducing FRDI, and improving depressive symptoms and QoL for women after surgery for BCa and during adjuvant treatment, and should be investigated in future studies.