Miracle-dz/UniFAR-FTUs huggingface dataset:
Heritability of refractive error and familial aggregation of myopia in an elderly American population.

PURPOSE To determine the heritability of refractive error and the familial aggregation of myopia in an older population. METHODS Seven hundred fifty-nine siblings (mean age, 73.4 years) in 241 families were recruited from the Salisbury Eye Evaluation (SEE) Study in eastern Maryland. Refractive error was determined by noncycloplegic subjective refraction (if presenting distance visual acuity was < or =20/40) or lensometry (if best corrected visual acuity was >20/40 with spectacles). Participants were considered plano (refractive error of zero) if uncorrected visual acuity was >20/40. Preoperative refraction from medical records was used for pseudophakic subjects. Heritability of refractive error was calculated with multivariate linear regression and was estimated as twice the residual between-sibling correlation after adjusting for age, gender, and race. Logistic regression models were used to estimate the odds ratio (OR) of myopia, given a myopic sibling relative to having a nonmyopic sibling. RESULTS The estimated heritability of refractive error was 61% (95% confidence interval [CI]: 34%-88%) in this population. The age-, race-, and sex-adjusted ORs of myopia were 2.65 (95% CI: 1.67-4.19), 2.25 (95% CI: 1.31-3.87), 3.00 (95% CI: 1.56-5.79), and 2.98 (95% CI: 1.51-5.87) for myopia thresholds of -0.50, -1.00, -1.50, and -2.00 D, respectively. Neither race nor gender was significantly associated with an increased risk of myopia. CONCLUSIONS Refractive error and myopia are highly heritable in this elderly population.
Durable graph pattern queries on historical graphs

In this paper, we focus on labeled graphs that evolve over time. Given a sequence of graph snapshots representing the state of the graph at different time instants, we seek to find the most durable matches of an input graph pattern query, that is, the matches that exist for the longest period of time. The straightforward way to address this problem is by running a state-of-the-art graph pattern algorithm at each snapshot and aggregating the results. However, for large networks this approach is computationally expensive, since all matches have to be generated at each snapshot, including those appearing only once. We propose a new approach that uses a compact representation of the sequence of graph snapshots, appropriate time indexes to prune the search space and a threshold on the duration of the pattern to determine the search order. We also present experimental results using real datasets that illustrate the efficiency and effectiveness of our approach.
Applicability of Brown and Levinson’s Politeness Theory to a Non-Western Culture

To examine applicability of Brown and Levinson’s politeness theory to facework in a non-Western culture, we conducted a questionnaire survey of native Japanese speakers. A rank order of influences on facework behavior was investigated among the five factors: (a) intrinsic factor (Ri; that is, effects caused by difference in settings), (b) contextual factor (Rc; that is, effects caused by difference in types of interlocutor’s contradictory attitudes), (c) power factor (P; that is, effects caused by age difference with the interlocutor), (d) distance factor (D; that is, effects caused by difference in familiarity with the interlocutor), and (e) gender factor (G; that is, whether the participant is male or female). Results revealed that factors related to the intrinsic content of the situation (Ri) and the interlocutor’s attitudes (Rc) had stronger influences than those of the inter- and intrapersonal factors of P, D, and G. Based on these findings, we conclude that Brown and Levinson’s formula is applicable to a non-Western culture, Japan.
Estradiol and GPER Activation Differentially Affect Cell Proliferation but Not GPER Expression in the Hippocampus of Adult Female Rats

Estradiol increases cell proliferation in the dentate gyrus of the female rodent but it is not known whether the G protein-coupled estrogen receptor (GPER), a membrane receptor, is involved in this process, nor whether there are regional differences in estradiol’s effects on cell proliferation. Thus, we investigated whether estradiol exerts its effects on cell proliferation in the dorsal and ventral dentate gyrus through GPER, using the GPER agonist, G1, and antagonist, G15. Ovariectomized adult female rats received a single injection of either: 17β-estradiol (10 μg), G1 (0.1, 5, 10 μg), G15 (40 μg), G15 and estradiol, or vehicle (oil, DMSO, or oil+DMSO). After 30 min, animals received an injection of bromodeoxyuridine (BrdU) and were perfused 24 h later. Acute treatment with estradiol increased, while the GPER agonist G1 (5 μg) decreased, the number of BrdU+ cells in the dentate gyrus relative to controls. The GPER antagonist, G15 increased the number of BrdU+ cells relative to control in the dorsal region and decreased the number of BrdU+ cells in the ventral region. However, G15 treatment in conjunction with estradiol partially eliminated the estradiol-induced increase in cell proliferation in the dorsal dentate gyrus. Furthermore, G1 decreased the expression of GPER in the dentate gyrus but not the CA1 and CA3 regions of the hippocampus. In summary, we found that activation of GPER decreased cell proliferation and GPER expression in the dentate gyrus of young female rats, presenting a potential and novel estrogen-independent role for this receptor in the adult hippocampus.
Identification of Virulence Genes Linked with Diarrhea Due to Atypical Enteropathogenic Escherichia coli by DNA Microarray Analysis and PCR

ABSTRACT The role of atypical enteropathogenic Escherichia coli (EPEC) in childhood diarrhea is controversial. The aim of the present study was to search for genes linked with diarrhea in atypical EPEC strains from a case-control study among Norwegian children. Using DNA microarray analysis, genomic DNAs from strains isolated from children with (n = 37) and without (n = 20) diarrhea were hybridized against 242 different oligonucleotide probes specific for 182 virulence genes or markers from all known E. coli pathotypes. PCR was performed to test the strains for seven putative virulence genes not included in the microarray panel. The OI-122 gene efa1/lifA was the gene with the strongest statistical association with diarrhea (P = 0.0008). Other OI-122 genes (set/ent, nleB, and nleE) and genes with other locations (lpfA, paa, ehxA, and ureD) were also associated with diarrheal disease. The phylogenetic marker gene yjaA was negatively associated with diarrhea (P = 0.0004). Atypical EPEC strains could be classified in two main virulence groups based on their content of OI-122, lpfA, and yjaA genes. Among children with diarrhea, atypical EPEC isolates belonging to virulence group I (OI-122 and lpfA positive, yjaA negative) were the most common, while the majority of isolates from healthy children were classified as virulence group II strains (OI-122 negative, lpfA and yjaA positive; P < 0.001). In conclusion, using DNA microarray analysis to determine the virulence gene profile of atypical EPEC isolates, several genes were found to be significantly associated with diarrhea. Based on their composition of virulence genes, the majority of strains could be classified in two virulence groups, of which one was seen mainly in children with diarrhea.
A review of knowledge management strategies – issues, contexts and benefits for the construction industry

In the last few years, knowledge management has become one of the hot topics discussed by scholars and industry practitioners. There is also an increasing awareness that to survive and maintain sustained competitive advantage in an uncertain and global market place, organisations need to give due consideration strategies that lead to effective knowledge management initiatives and outcomes. Despite the increasing in adoption of knowledge management concepts and initiatives in other industrial sectors, the construction industry has, arguably, been slow to adopt effective knowledge management practices and strategies; hence many construction organisations are yet to fully exploit the potential benefits of knowledge management concepts and initiatives. The main objectives this paper are, inter alia, to identify the importance and benefits of formal and informal knowledge management approaches in construction organisations and to critically appraise some of the strategies of knowledge management being adopted by organisations from which lessons learned are discussed for the benefits of the construction industry. The paper concludes that there are many knowledge management strategies currently being adopted and used by organisations and each having its own strengths, weaknesses, benefits and potentials. It also concludes that there is no one knowledge management strategy that is likely to lead to successful outcomes in all organisations, but there are certain issues worthy of consideration in developing a knowledge management strategy that offers potential for success. The realisation of this success will, however, depend on a host of factors, including organisational capabilities. This latter conclusion leads to important recommendations for the attention or industry, organisations and the academic community. These are also documented in the paper.
A PAC Bound for Approximate Support Vector Machines

We study a class of algorithms that speed up the training process of support vector machines (SVMs) by returning an approximate SVM. We focus on algorithms that reduce the size of the optimization problem by extracting from the original training dataset a small number of representatives and using these representatives to train an approximate SVM. The main contribution of this paper is a PAC-style generalization bound for the resulting approximate SVM, which provides a learning theoretic justification for using the approximate SVM in practice. The proved bound also generalizes and includes as a special case the generalization bound for the exact SVM, which denotes the SVM given by the original training dataset in this paper. Keyword: Support Vector Machines, Approximate Solutions, Generalization Bounds, Algorithmic Stability
Probabilistic Arabic part of speech tagger with unknown words handling

Part Of Speech (POS) tagger is an essential preprocessing step in many natural language applications. In this paper, we investigate the best configuration of trigram Hidden Markov Model (HMM) Arabic POS tagger when small tagged corpus is available. With small training data, unknown word POS guessing is the main problem. This problem becomes more serious in languages which have huge size of vocabulary and rich and complex morphology like Arabic. In order to handle this problem in Arabic POS tagger, we have studied the effect of integrating a lexicon based morphological analyzer to improve the performance of the tagger. Moreover, in this work, several lexical models have been empirically defined, implemented and evaluated. These models are based essentially on the internal structure and the formation process of Arabic words. Furthermore, several combinations of these models have been presented. The POS tagger has been trained with a training corpus of 29300 words and it uses a tagset of 24 different POS tags. Our system achieves state-of-the-art overall accuracy in Arabic part of speech tagging and outperforms other Arabic taggers in unknown word POS tagging accuracy.
Rapid on-line detection and grading of wooden breast myopathy in chicken fillets by near-infrared spectroscopy

The main objective of this work was to develop a method for rapid and non-destructive detection and grading of wooden breast (WB) syndrome in chicken breast fillets. Near-infrared (NIR) spectroscopy was chosen as detection method, and an industrial NIR scanner was applied and tested for large scale on-line detection of the syndrome. Two approaches were evaluated for discrimination of WB fillets: 1) Linear discriminant analysis based on NIR spectra only, and 2) a regression model for protein was made based on NIR spectra and the estimated concentrations of protein were used for discrimination. A sample set of 197 fillets was used for training and calibration. A test set was recorded under industrial conditions and contained spectra from 79 fillets. The classification methods obtained 99.5–100% correct classification of the calibration set and 100% correct classification of the test set. The NIR scanner was then installed in a commercial chicken processing plant and could detect incidence rates of WB in large batches of fillets. Examples of incidence are shown for three broiler flocks where a high number of fillets (9063, 6330 and 10483) were effectively measured. Prevalence of WB of 0.1%, 6.6% and 8.5% were estimated for these flocks based on the complete sample volumes. Such an on-line system can be used to alleviate the challenges WB represents to the poultry meat industry. It enables automatic quality sorting of chicken fillets to different product categories. Manual laborious grading can be avoided. Incidences of WB from different farms and flocks can be tracked and information can be used to understand and point out main causes for WB in the chicken production. This knowledge can be used to improve the production procedures and reduce today’s extensive occurrence of WB.
Recommendations for Creating Better Concept Definitions in the Organizational, Behavioral, and Social Sciences

Despite the importance of establishing good, clear concept definitions in organizational research, the field lacks a comprehensive source that explains how to effectively develop and articulate a concept’s domain. Thus, the purpose of this article is to explain why clear conceptual definitions are essential for scientific progress and provide a concrete set of steps that researchers can follow to improve their conceptual definitions. First, we define what is meant by a concept, describe the functions served by concepts in scientific endeavors, and identify problems associated with a lack of conceptual clarity. Then we explain why it is so difficult to adequately define concepts. Next, we provide a series of recommendations for scholars in the organizational, behavioral, and social sciences who are either trying to define a new concept or revise the definition of one that already exists in the field. Following this, we provide some examples that generally meet the criteria for a good conceptual definition. We conclude with a set of questions that authors, reviewers, and editors can use as a guide for evaluating concept definitions.
Evaluation of JC and Cytomegalo Viruses in Glioblastoma Tissue

Glioblastoma multiforme (GBM) is the most aggressive of the gliomas, a collection of tumors arising from glia in the central nervous system. Possible associations between the human cytomegalovirus (HCMV) and the JC virus with GBM are now attracting interest. Our present aim was to investigate the prevalence of the two viruses in Iranian patients from Kerman’s cities in the south of Iran. In addition, the expression rates of pp65, large T antigen and p53 proteins were assessed and their relation with GBM evaluated using reverse transcription real time PCR (rReal Time PCR). A total of 199 patients with GBM cancer were enrolled, with mean±SD ages of 50.0±19.5 and 50.7±19.6 years for males and females, respectively. The P53 rate was dramatically low suggesting an aetiological role,. Large T antigen expression was found in JC positive samples, while the PP65 antigen was observed in patients positive for CMV and JC. HCMV products and JC virus with oncogenic potential may induce the development of various tumors including glioblastomas. The JC virus produces an early gene product, T-antigen, which has the ability to associate with and functionally inactivate well-studied tumor suppressor proteins including p53 and pRB.
One-stage management of infected sternotomy wounds using bilateral pectoralis major myocutaneous advancement flap.

OBJECTIVE To assess the results of single-stage treatment of infected sternotomy wounds using bilateral pectorals major myocutaneous advancement flaps. METHODS Between January 2000 and July 2007, 1972 heart surgeries with median transesternal thoracotomy were performed. Thirteen (0.65%) patients presented wound infections and dehiscence after sternotomy. To treat those patients we adopted exclusively single-stage management, drainage, early intervention and immediate wounds closure using bilateral pectoralis major myocutaneous advancement flaps to the medium line of the sternum. Two patients with superficial wounds infection and other two who underwent torsion adjustment of the steel wire were not included in this study. RESULTS There was one death in the 30-day postoperative period. There was no intraoperative death. Four patients needed additional surgical intervention to drain residual seroma or local infection. There was total resolution of the sternal infection in 12 patients. CONCLUSION The authors recommend the single-stage early management of sternotomy infected wounds with debridement, drainage and immediate closure of the wound using bilateral pectoralis major myocutaneous advancement flaps to the medium line of the sternum. The procedure is effective and may contribute to decrease the morbidity.
Family Oversight and the Quality of Nursing Home Care for Residents With Advanced Dementia

Background:The quality of nursing home (NH) care for residents with advanced dementia has been described as suboptimal. One relatively understudied factor in the provision of NH care is the role of private oversight and monitoring by family members and friends. Objective:To examine the association between private oversight and the quality of end-of-life care for NH residents with advanced dementia. Research Design:This study employed longitudinal data on 323 NH residents with advanced dementia living in 22 Boston area facilities. Using bivariate and multivariate methods, we analyzed the association between visit time by the resident's health care proxy (HCP) and measures of quality of end-of-life care. Results:The relationship between visit time and quality was nonlinear. Residents who were visited 1 to 7 h/wk had less pain, fewer pressure ulcers, less dyspnea, and fewer hospital transfers compared with residents who had no visits or who were visited >7 h/wk. After adjusting for covariates, residents who were visited >7 h/wk had more pressure ulcers, more pain, greater dyspnea, fewer do-not-hospitalize orders, and lower HCP satisfaction with care compared with residents who were visited 1 to 7 h/wk. Conclusions:Several measures of quality of NH care for end-stage dementia exhibit a nonlinear relationship with the degree of HCP oversight, such that no visiting or very high levels of visiting are associated with worse quality. Future research will need to address whether families with greater oversight tend to make decisions that promote worse quality of care, or whether worse quality of care promotes greater family oversight.
A theory-based intervention to reduce alcohol drinking in excess of guideline limits among undergraduate students.

OBJECTIVES Undergraduate students frequently exceed guideline limits for alcohol intake in a single session and are highly susceptible to associated health, social, and economic problems. Psychological theory suggests that interventions aimed at reducing alcohol consumption should target both motivational and volitional phases of action to be effective. This study reports an integrated theory-based intervention aimed at reducing undergraduates' alcohol consumption in excess of guideline limits. DESIGN The study adopted a 2 (motivation: mental simulation vs. no mental simulation) × 2 (volitional: implementation intention vs. no implementation intention) randomized controlled design presented in an online format. METHODS Undergraduate students (N= 238; females, n= 133, M age = 20.11, SD= 2.09; males, n= 105, M age = 20.38, SD= 1.35) completed baseline psychological measures and self-reported alcohol consumption as units consumed and heavy episodic drinking occasions followed by the intervention manipulation (if any). One month later participants completed follow-up measures of the psychological variables and alcohol consumption. RESULTS Significant reductions in alcohol consumption were observed at follow-up. Participants receiving a mental simulation intervention reported significantly fewer units of alcohol consumed and heavy episodic drinking occasions. Among participants with high baseline alcohol consumption, participants in the combined mental simulation and implementation intention intervention group consumed significantly fewer units than other groups. CONCLUSION Results support the use of these theory-based strategies to reduce alcohol drinking in excess of guideline limits among undergraduates. There was preliminary support for the interaction between the two strategies among heavier drinkers. Targeting both motivational and implemental phases of action poses a high probability for success in changing alcohol-related behaviour in this population.
Subject Relationships within Serial Verb Constructions in Numbami and Jabem

This paper outlines the evidence for verb serialization in Numbami, an Austronesian language of Papua New Guinea, noting parallels with Jabem. The paper then focusses on subject relationships within serial verb constructions in Numbami and Jabem. These two languages allow not only the same subject and switch-subject serialization, but also verbal-subject serialization. In addition, Jabem allows a fourth possibility: ambient-subject serialization.
Disability and Living with HIV: Baseline from a Cohort of People on Long Term ART in South Africa

Background Through access to life saving antiretroviral treatment (ART) in southern Africa, HIV has been reconceptualised as a chronic disease. This comes with new challenges of HIV-related co-morbidities and disabilities. We still lack an understanding of the types and scope of disabilities experienced by people on long term ART and how this impacts health, adherence, and livelihood. This paper describes the results of a cohort study examining the new health- and disability-related needs of the millions of people on ART in the region. Methods Data was collected from a cohort of people who had been on ART for six months or longer in a semi-urban public health care setting in South Africa. 1042 adults (18 and older) participated in the cross-sectional study which investigated disabilities/activity limitations, health, ART adherence, depression symptoms, and livelihood. We analysed the associations between these constructs using descriptive statistics, and bivariate and multivariate analyses. Results A large number of participants (35.5%) obtained a weighted score of two or more on the WHODAS 2.0 indicating possible activity limitations. A positive relationship was found between activity limitations and depression symptoms, adherence, and worse health outcomes, while none was found for BMI or CD4 count. These associations varied by type of activity limitations and, in some cases, by gender. Conclusion Activity limitations are potentially experienced by a large portion of people on ART in southern Africa which impacts health and ART adherence negatively. These results highlight the importance of better understanding the new health-related needs of people who are on long term ART, as well as the nuances of the disability they experience. This is urgently needed in order to enable HIV-endemic countries to better prepare for the new health-related needs of the millions of people on ART in southern Africa.