Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of screening methods for anthracnose fruit rot resistance in chilli (Capsicum spp.)

Anthracnose fruit rot caused by Colletotrichum spp. is a serious production constraint causing severe marketable yield loss in chilli. Field evaluation of chilli accessions for resistance to Colletotrichum spp. depends on various factors affecting disease expression such as edaphic conditions, temperature, rainfall, humidity and other variables that are difficult to control, therefore considered less accurate. Also, high chances of cross contamination with different Colletotrichum species leads to inconclusive assays for specific pathogen species and isolate. To identify a stable and reliable screening method, various chilli accessions were subjected to in vitro pin-prick and non-wounding spray methods using a specific pathogen isolates. When chilli accessions were screened against C. gloeosporioides isolate ‘IHRCg-1’, the in vitro pin- prick method showed positive correlation with the non- wounding spray method, except in the accession PBC80. The change in bioassay influenced the disease reaction pattern in the accession PBC 80, probably the pin pricks break the basal cuticle defense mechanism that was retained in spray inoculation method indicating varied resistance pattern. However, in the accession PBC 81 stable resistance pattern was observed against isolates of both species viz., C. truncatum ‘IIHR Ct-1’ and C. gloeosporioides ‘IIHR Cg-1’ and in the accession PBC 80 against C. truncatum ‘IIHR Ct-1’ in both the inoculation methods that depicted the expression of resistance genes during both methods of inoculation. Based on disease development pattern, the red ripe chilli expressed a variant reaction to infection by C. truncatum and C. gloeosporioides. The peak anthracnose infection at 10 DAI and 14 DAI is an accurate duration to record ‘IIHR Cg-1’ and ‘IIHR Ct-1’ infection, respectively on chilli ripe fruit for assaying the resistance.
Abnormal cardiovascular sympathetic and parasympathetic responses to physical and emotional stimuli in depersonalization disorder

Background Depersonalization disorder (DPD) is characterized by a subjective sense of unreality, disembodiment, emotional numbing and reduced psychogenic (sudomotor) sympathoexcitation. Aims Three related experiments utilized escalating physical and emotional challenges in 14 DPD participants and 16 controls aimed to elucidate (i) whether the cardiovascular sympathetic (SNS) and parasympathetic (PNS) nervous systems are implicated in DPD pathophysiology and (ii) if possible, to determine whether the blunted sympathoexcitation in DPD is peripherally or centrally mediated. Method Participants completed the Beck Anxiety Inventory (BAI), Dissociative Experience Scale (DES), and Cambridge Depersonalization Scale (CDS). Study I recorded heart rate (HR) and blood pressure (BP) during 5 min supine baseline, 3 min sustained handgrip (HG), 3 min cold pressor (CP) and 5 min 60° head-up tilt (HUT). In study II, HR, BP, and heart rate variability (HRV) were recorded during 5 min simultaneous 60° HUT and continuous presentation of unpleasant images (5 s per image). Study III examined HR and BP orienting responses (ORs) to simultaneous 60° HUT and pseudorandom presentation of unpleasant, neutral and pleasant images (5 s per image 3 min 25 s). OR data was grouped by image valence post hoc. Results DPD BAI (p = 0.0004), DES (p = 0.0002), and CDS (p ≤ 0.0001) scores were higher than controls. The DPD group produced diminished diastolic BP (DBP) (p = 0.045) increases to HG. Other indices were comparable between groups. DPD participants produced diminished systolic BP (SBP) (p = 0.003) and DBP (p = 0.002) increases, but greater (p = 0.004) HR increases to CP. In study II, DPD high frequency HRV (HF-HRV)—indicating parasympathetic vagal activity–was reduced (p = 0.029). In study III, DPD DBP was higher throughout the 5 s duration of HUT/pseudorandom unpleasant image presentation (1 s, p = 0.002, 2 s p = 0.033, 3 s p = 0.001, 4 s p = 0.009, 5 s p = 0.029). Conclusions Study I's BP pressor data supports previous findings of suppressed sympathoexcitation in DPD. The greater HR increases to CP, decreased HF-HRV in study II, and increased DBP during unpleasant ORs in study III implicates the SNS and PNS in DPD pathophysiology. These studies suggest the cardiovascular autonomic dysregulation in DPD is likely to be centrally-mediated.
A multi-ion permeation mechanism in neuronal background chloride channels

Unitary current/voltage relationships of background Cl channels of rat hippocampal neurons were determined for varied gradients and absolute concentrations of NaCl. The channels revealed permeabilities for both Cl and Na ions. A hyperlinear increase of unitary conductance, observed for a symmetrical increase of salt concentration from 300 and 600 mM, indicated a multi-ion permeation mechanism. A variety of kinetic models of permeation were tested against the experimental current/voltage relationships. Models involving a pore occupied by mixed complexes of up to five ions were necessary to reproduce all measurements. A minimal model included four equilibrium states and four rate-limiting transitions, such that the empty pore accepts first an anion and then can acquire one or two cation/anion pairs. Three transport cycles are formed: a slow anion cycle (between the empty and single-anion states), a slow cation cycle (between the one- and three-ion states), and a fast anion cycle (between the three- and five-ion states). Thus, permeant anions are required for cation permeation, and several bound anions and cations promote a high rate of anion permeation. The optimized free- energy and electrical charge parameters yielded a self-consistent molecular interpretation, which can account for the particular order in which the pore accepts ions from the solutions. Although the model describes the mixed anion/cation permeability of the channel observed at elevated concentrations, it predicts a high selectivity for Cl anion at physiological ionic conditions.
Patients’ Experiences of Daily Living with a Pacemaker

The purpose of this study was to examine patients’ experiences of daily living with a pacemaker. A total of 13 pacemaker patients (seven women) aged 22-82 (mean = 59.2) years were interviewed. The informants had had a pacemaker from 0.5 to 33 (mean 13.1) years. The grounded theory method was the basis for collection and analysis of the data. The results of the analysis of the semi-structured interviews showed that variations in ‘perceived social participation’ and ‘emotional state’, the two core categories, were related to four qualitatively different ways of experiencing daily living after pacemaker implantation.
Pretanned leather shavings in a supplement mixture for steers: II. Digesta kinetics, ruminal fermentation, and grazing behavior in steers grazing dormant wheatgrass pasture.

Twelve ruminally cannulated steers (Angus x Holstein; average initial BW = 533 +/- 3.28 kg) were randomly allotted to one of three treatments (four steers/treatment) to evaluate the use of pretanned leather shavings as a component of a protein supplement for steers grazing dormant intermediate wheatgrass (Thinopyrum intermedium Host). Steers were allotted to one of three treatments: 1) no supplement (control); 2) supplementation intraruminally at 0700 with soybean meal at . 2% of BW (as-fed basis); 3) supplementation intraruminally with soybean meal and pretanned leather shavings (17:8 ratio, respectively) at . 16% of BW (as-fed basis). Supplements were formulated so that intakes were isonitrogenous and were placed intraruminally once daily (0700). Sampling periods were conducted February 3 to 16 and February 17 to March 5, 1995. In situ organic matter disappearance of the soybean meal supplement was greater (P > .05) than that of the leather shavings supplement at all incubation times (1, 3, 6, 9, 12, 24, and 48 h). Data suggested that pretanned leather shavings within the leather shavings supplement were only 25% degradable within the rumen. Forage OM intake (control = 12.7, soybean meal = 12.7, and leather shavings = 13.4 g/kg of BW), grazing time, and grazing efficiency were not altered (P > .10) by supplementation or type of supplement provided but did increase between the February and March samplings. Total intake was increased (P = .09) with supplementation and reflected the addition of the protein supplements. Particulate and fluid passage estimates were unaffected (P > .10) by the supplements; however, gastrointestinal fill increased (P = .01) between the February and March samplings. Ruminal pH was lower (P = .04) and ruminal NH3 N concentration was greater (P = .02) for supplemented steers than for control steers, and supplementation treatments did not differ (P > .10). Total VFA concentrations were increased (P = .01) by supplementation but were not affected by type of supplement provided (P > .10). Ruminal molar proportions of acetate and propionate and the ratio of these two VFA did not differ (P > .10) between supplementation types. Nonetheless, supplementation increased molar proportions of butyrate (P = .04), valerate (P = .02), and isovalerate (P = .05), and leather shavings supplementation increased (P = .10) isobutyrate proportions over those in steers supplemented with soybean meal. Combining pretanned leather shavings with soybean meal seemed to have no deleterious effects on forage intake, digesta passage, grazing behavior, or ruminal fermentation and seemed to provide effects similar to those of soybean meal alone.
Land-use practices influence nutrient concentrations of southwestern Ontario streams

Human activities have transformed the landscape and altered geochemical pathways through intensive land uses such as agriculture and urbanization. This study quantified the individual and cumulative influence of land-use drivers on nutrient concentrations for 29 Ontario tributaries flowing to Lake Erie and Lake Huron. For each watershed, measures of agriculture, urbanization and population served by municipal sewage treatment plants were quantified at multiple spatial scales; stream-water nutrients (nitrogen, N, and phosphorus, P) were sampled on 10 occasions between May and November 2012, and were also compiled from government records for concurrent (2012) and prior (2007, 2008, 2011) years. Application of ordinary least squares regression analysis showed that in 2012, concentrations of N and P (total as well as dissolved forms) were primarily driven by sewage treatment and urban activity, with agricultural activity as a secondary influence on variability. Evaluation of model predictive performance under scenarios of varying climate (wet, dry and ‘normal’ conditions) and spatial coverage (i.e. broader than the original sampling sites) showed that stream nitrogen concentrations could be predicted, on average, 36–85% of the time; phosphorus forms were, however, not successfully predicted, likely due to differences in sampling frequency relative to runoff events. The finding that both urban and agricultural land-use activities influence nutrient concentrations in Canadian tributaries to lakes Erie and Huron underscores the need to reduce both point and non-point inputs in order to mitigate eutrophication of downstream lakes.
Molecular changes in invasive front of oral cancer

Treatment planning for oral squamous cell carcinoma (OSCC) is based on the clinical TNM (Tumor, Node and Metastasis) classification. This system operates on the assumption that small tumours without clinical spread have a better prognosis than larger tumours with metastases. However, it is a well-known fact that some tumours with the same clinical staging show different growth patterns and clinical behaviour. This makes the prognosis for patients with OSCC difficult to predict on the basis of clinical staging alone. Although many histopathological characteristics of OSCC have been identified as prognostic factors, none is believed to be completely infallible. Therefore, a great need exists for more reliable prognostic markers, which will assist in treatment decisions. It is now well documented that several molecular events of significance for tumour spread, such as gain and loss of adhesion molecules, secretion of proteolytic enzymes, increased cell proliferation and initiation of angiogenesis occur at the tumour–host interface or invasive front, where the deepest and presumably most aggressive cells reside. This review describes the various molecular events and interactions, which take place in the invasive front of the OSCC, and elucidates their role as prognostic markers.
Effects of Chronic ACTH Excess on Human Adrenal Cortex

Chronic ACTH excess leads to chronic cortisol excess, without escape phenomenon, resulting in Cushing’s syndrome. Excess adrenal androgens also occur: in females, they will overcompensate the gonadotrophic loss, inducing high testosterone; in males, they will not compensate it, inducing low testosterone. Chronic ACTH excess leads to chronic adrenal mineralocorticoid excess and low aldosterone levels: after an acute rise, aldosterone plasma levels resume low values after a few days when ACTH is prolonged. Two other mineralocorticoids in man, cortisol and 11 deoxycorticosterone (DOC), at the zona fasciculata, will not escape the long-term effect of chronic ACTH excess and their secretion rates will remain elevated in parallel. Over all, the concomitant rise in cortisol and 11 DOC will more than compensate the loss of aldosterone, and eventually create a state of chronic mineralocorticoid excess, best evidenced by the accompanying suppression of the renin plasma levels, a further contribution to the suppression of aldosterone secretion. Prolonged in vivo stimulation with ACTH leads to an increase in total adrenal protein and RNA synthesis. Cell proliferation is indicated by an increase in total DNA the resulting adrenocortical hyperplasia participates in the amplified response of the chronically stimulated gland, and the weight of each gland can be greatly increased. The growth-stimulatory effect of ACTH in vivo most likely proceeds through the activation of a local and complex network of autocrine growth factors and their own receptors; a number of compounds, including non-ACTH proopiomelanocortin peptides such as γ3-MSH, have been shown to exert some adrenocortical growth effect.
Biomarkers in the Diagnosis of Endometrial Precancers. Molecular Characteristics, Candidate Immunohistochemical Markers, and Promising Results of Three-Marker Panel: Current Status and Future Directions

Simple Summary Endometrial carcinoma is a common type of cancer in women, ranking as the most frequent gynecological cancer and the fourth most common overall. Its occurrence has been rising steadily, becoming a serious health concern. Detecting its immediate precursors, known as precancers, is crucial for saving lives. In recent years, research into the genetic makeup of endometrial carcinoma and its precancers has progressed, especially focusing on the most common subtype called endometrioid. New biomarkers have been discovered that could help in identifying precancers, potentially improving diagnosis and treatment. This review summarizes these recent discoveries and their significance in diagnosing precancers of endometrial carcinoma. Abstract Endometrial carcinoma stands as the most prevalent gynecological cancer and the fourth most common cancer affecting women. The incidence of endometrial cancer has been steadily increasing over the past decade, posing a significant threat to public health. The early detection of its precancers remains a critical and evolving concern to reduce mortality associated with endometrial carcinoma. In the last decade, our understanding of endometrial carcinoma and its precancers has advanced through systematic investigations into the molecular genetics of endometrial carcinoma and its precancers. In this review, we focus on advances in precancers associated with the endometrioid subtype, by far the most common histologic variant of endometrial adenocarcinoma. Recent investigations have led to the identification of new biomarkers, and the proposed incorporation of these biomarkers or biomarker panels into the diagnostic framework of endometrial carcinoma precancers. Here, we review these recent advances and their relevance to the histopathologic diagnosis of endometrial carcinoma precancers.
Murine B cell differentiation lineages

Subpopulations of mouse B cells express different amounts of two antigens (BLA-1 and BLA-2) recognized by rat monoclonal antibodies (53- 10.1 and 30-E2). Two-color immunofluorescence analysis on the fluorescence-activated cell sorter (FACS) shows that the 53-10.1 monoclonal antibody reacts with a similar proportion of splenic B cells from normal and CBA/N (xid) mice, whereas 30-E2 reacts with most CBA/N B cells but with only a fraction of normal B cells. Data from three- and four-color immunofluorescence analyses with xid, athymic (nude), and normal mice suggest that the order in which these antigens are lost during B cell differentiation distinguishes two B cell lineages: immature B cells express both antigens, intermediate-stage B cells of one or the other lineage express only BLA-1 or only BLA-2, respectively, and mature resting B cells express neither. CBA/N mice lack one of the putative intermediate populations (BLA-1+,2-); thus, this population apparently gives rise to the predominant mature B cell population, which is present in normal adult spleen and lymph node but is missing in CBA/N. The other putative intermediate population (BLA-1- ,2+) is decreased by two- to threefold in spleens from nude mice compared with strain-matched controls. Both BLA-1 and BLA-2 antigens rapidly reappear after specific (antigen) or nonspecific (lipopolysaccharide) B cell activation. IgM plaque-forming cells (PFC) derived from such activated cells continue to express both antigens while IgG PFC express only BLA-1.
WORKING PAPER NO . 11-2 A DYNAMIC MODEL OF UNSECURED CREDIT

We study the terms of credit in a competitive market in which sellers (lenders) are willing to repeatedly nance the purchases of buyers (borrowers) by engaging in a credit relationship. The key frictions are: (i) the lender is unable to observe the borrowers ability to repay a loan; (ii) the borrower cannot commit to any long-term contract; (iii) it is costly for the lender to contact a borrower and to walk away from a contract; and (iv) transactions within each credit relationship are not publicly observable. The lenders optimal contract has two key properties: delayed settlement and debt forgiveness. Asymmetric information gives rise to the property of delayed settlement, which is a contingency in which the lender allows the borrower to defer the repayment of his loan in exchange for more favorable terms of credit within the relationship. This property, together with the borrowerslack of commitment, gives rise to debt forgiveness. When the borrowers participation constraint binds, the lender needs to forgivepart of the borrowers debt to keep him in the relationship. Finally, we study the impact of the changes in the initial cost of lending on the terms of credit. Keywords: Unsecured Loans; Dynamic Contracting; Delayed Settlement; Debt Forgiveness; Initial Cost of Lending. JEL Classi cation Numbers: D8, E4, G2.
Examining social inclusion and social capital among adult learners in blended and online learning environments

New learning spaces and learning formats affected the learning and education of adults. In this respect, digitalisation is believed to reduce social exclusion. Moreover, adult education, social inclusion and social capital are positively related among adults. Therefore, this questionnaire study examines how adults who are engaged in online and blended learning perceived change in social inclusion and social capital. We conceptualised social inclusion as social participation and social connectedness, and social capital as bonding and bridging ties. In the case of blended adult learners, our results show positive perceptions of social inclusion and social capital. Those perceptions are less positive among the online adult learners. In both cases, non-natives experience a higher increase in social inclusion and social capital than natives. Hence, online and blended learning holds advantages for adults particularly non-natives: it enhances social inclusion and social capital. (DIPF/Orig.)
Impulsive synchronization on complex networks of nonlinear dynamical systems

This paper is concerned with applying the impulsive control scheme to generalized synchronization (GS) of complex networks of nonlinear dynamical systems. The auxiliary-system approach is utilized to show that complex dynamical networks consisting of nonidentical systems can reach generalized synchronization under impulsive control. Then the relations between the GS error and the topological parameter are examined for scale-free networks, which reveals that an increase in the topological parameter causes a decrease in the GS error. Also, the relations between the GS speed and the adding of random edges are investigated for small-world networks, which shows that increasing the probability of adding random edges can accelerate GS. Moreover, the effect of node dynamics on the GS speed is studied for both small-world and scale-free networks.
Measuring influence on Twitter

There are currently over 175 million Twitter accounts worldwide, making Twitter one of the most popular and most observed Social Media platform. But Twitter is not so much a social network where the exchange of personal information is facilitated -- in fact, recent surveys state that it's not very social at all with a large amount of inactive accounts and a low motivation of engaging in dialogues [1]. Twitter has rather evolved into a pool of constantly updating information streams consisting of links, short status updates, and eyewitness news. Among the millions of users, a small percentage is what is called the group of influencers or alpha users. They have a large, active audience that consumes and multiplies the content published by the influencer. Thus, an influencer's content -- whether it is plain text or links -- is distributed in a number of micro-networks and receives attention from a large amount of users even though they might not even be direct followers of the influencer. The further the content is spread, the further the influence of the user reaches. There are various tools that enable performance measurement on Social Media. Some only sum up numbers such as the amount of followers or mentions gained on Twitter; others interpret the numbers and rate the performance using a specific algorithm. An example for the latter is Klout, a popular service that will be looked at more closely, focusing on the question of how Klout calculates its scores which serve as a means of measuring success of Twitter usage. The research purpose of this paper is to determine a grounded approach for measuring social networking potential of individual Twitter users.