Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationships between Body Fat Distribution, Epicardial Fat and Obstructive Sleep Apnea in Obese Patients with and without Metabolic Syndrome

Background Obstructive sleep apnea (OSA) and metabolic syndrome, both closely related to obesity, often coexist in affected individuals; however, body mass index is not an accurate indicator of body fat and thus is not a good predictor of OSA and other comorbidities. The aim of this study was to investigate whether the occurrence of OSA could be associated with an altered body fat distribution and a more evident cardio metabolic risk independently from obesity and metabolic syndrome. Methods and Results 171 consecutive patients (58 men and 113 women) were included in the study and underwent overnight polysomnography. Anthropometric data, blood pressure, lipid profile, glycaemic parameters were recorded. Body composition by DXA, two-dimensional echocardiography and carotid intima/media thickness measurement were performed. 67 patients (39.2%) had no OSA and 104 (60.8%) had OSA. The percentage of patients with metabolic syndrome was significantly higher among OSA patients (65.4%) that were older, heavier and showed a bigger and fatter heart compared to the control group. Upper body fat deposition index , the ratio between upper body fat (head, arms and trunk fat in kilograms) and lower body fat (legs fat in kilograms), was significantly increased in the OSA patients and significantly related to epicardial fat thickness. In patients with metabolic syndrome, multivariate regression analyses showed that upper body fat deposition index and epicardial fat showed the best association with OSA. Conclusion The occurrence of OSA in obese people is more closely related to cardiac adiposity and to abnormal fat distribution rather than to the absolute amount of adipose tissue. In patients with metabolic syndrome the severity of OSA is associated with increase in left ventricular mass and carotid intima/media thickness.
Modifying sense of place in a federal company town: Sunflower Village, Kansas, 1942 to 1959

The federal government built Sunflower Village, Kansas, to house employees of the Sunflower Ordnance Plant and their families during World War II. The community existed in this fashion until 1959 when a private real-estate developer bought the land and buildings. The Village evolved out of many perspectives in urban planning including those of federal ownership, ‘Garden City’ communities, and private company towns. This study examines a modified, or unique, development of sense of place that evolved here due to these varied urban forms and despite evidence of mobility and a short residence. Landscape analysis, archival searches and personal interviews also reveal a distinct difference in the experiences of youth and adults that resulted in varying processes of attachment within the community.
Dashed hopes, dashed selves? A sociometer perspective on self-esteem change across the transition to secondary school

The transition from primary to secondary school challenges children's psychological well-being. A cross-transitional longitudinal study (N = 306; mean age = 12.2 years) examined why some children's self-esteem decreases across the transition whereas other children's self-esteem does not. Children's expected social acceptance in secondary school was measured before the transition; their actually perceived social acceptance was measured after the transition. Self-esteem and Big Five personality traits were measured both pre- and posttransition. Self-esteem changed as a function of the discrepancy between children's expected and actually perceived social acceptance. Furthermore, neuroticism magnified self-esteem decreases when children's ‘hopes were dashed'—when they experienced disappointing levels of social acceptance. These findings provide longitudinal support for sociometer theory across the critical transition to secondary school.
Racially Biased Policing: Determinants of Citizen Perceptions

The current controversy surrounding racial profiling in America has focused renewed attention on the larger issue of racial bias by the police. Yet little is known about the extent of police racial bias and even less about public perceptions of the problem. This article analyzes recent national survey data on citizens' views of, and reported personal experiences with, several forms of police bias—including differential treatment of individuals and neighborhoods, police prejudice, and racial profiling. We find that attitudes toward the prevalence and acceptability of these practices are largely shaped by citizens' race, personal experiences with police discrimination, and exposure to news media reporting on incidents of police misconduct. The findings lend support to the group-position theory of race relations.
Immunological Monitoring to Rationally Guide AAV Gene Therapy

Recent successes with adeno-associated virus (AAV)-based gene therapies fuel the hope for new treatments for hereditary diseases. Pre-existing as well as therapy-induced immune responses against both AAV and the encoded transgenes have been described and may impact on safety and efficacy of gene therapy approaches. Consequently, monitoring of vector- and transgene-specific immunity is mandated and may rationally guide clinical development. Next to the humoral immune response, the cellular response is central in our understanding of the host reaction in gene therapy. But in contrast to the monitoring of antibodies, which has matured over many decades, sensitive and robust monitoring of T cells is a relatively new development. To make cellular immune assessments fit for purpose, investigators need to know, control and report the critical assay variables that influence the results. In addition, the quality of immune assays needs to be continuously adjusted to allow for exploratory hypothesis generation in early stages and confirmatory hypothesis validation in later stages of clinical development. The concept of immune assay harmonization which includes use of field-wide benchmarks, harmonization guidelines, and external quality control can support the context-specific evolution of immune assays. Multi-center studies pose particular challenges to sample logistics and quality control of sample specimens. Cooperative groups need to define if immune assessments should be performed in one central facility, in peripheral labs or including a combination of both. Finally, engineered reference samples that contain a defined number of antigen-specific T cells may become broadly applicable tools to control assay performance over time or across institutions.
Inhibition of Monocarboxylate Transporter 2 Induces Senescence-Associated Mitochondrial Dysfunction and Suppresses Progression of Colorectal Malignancies In Vivo

Senescence, an inherent tumor suppressive mechanism, is a critical determinant for chemotherapy. In the present study, we show that the monocarboxylate transporter 2 (MCT2) protein was tumor-selectively expressed in human colorectal malignancies and knockdown of MCT2 induces mitochondrial dysfunction, cell-cycle arrest, and senescence without additional cellular stress in colorectal cancer cell lines. Moreover, the reactive oxygen species (ROS) scavenger, N-acetylcysteine, blocked MCT2 knockdown-induced growth arrest and cellular senescence, indicating a pivotal role of ROS in this pathway. Dramatic induction of mitochondrial superoxide generation and decrease in ATP production was observed, indicating that mitochondrial dysfunction is the major mechanism underlying MCT2 knockdown-induced ROS generation. Senescence-associated DNA damage was also evident from the increase in promyelocytic leukemia bodies, γH2AX foci, and SAHF. Conversely, overexpression of MCT2 prevented doxorubicin-induced ROS accumulation (P = 0.0002) and cell growth inhibition (P = 0.001). MCT2 knockdown suppressed KRAS mutant colorectal tumor growth in vivo. In addition, MCT2 knockdown and cytostatic drug combination further enhanced the antitumor effect. These findings support the use of MCT2 as a promising target for inhibition of colorectal cancer. Mol Cancer Ther; 11(11); 2342–51. ©2012 AACR.
Intermittent Hypoglycemia Impairs Glucose Counterregulation

IDDM patients who maintain strict glycemic control have impaired counterregulatory hormone and symptomatic responses to hypoglycemia. To test the hypothesis that intermittent exposure to hypoglycemia plays an etiological role in these defective responses, we produced 4 consecutive daily episodes of hypoglycemia in 10 healthy, nondiabetic volunteers by using the insulin clamp technique. Fasting (5.3 ± 0.1 vs. 5.4 ± 0.1 mM) and nadir (2.3 ± 0.1 vs. 2.4 ± 0.1 mM) glucose levels achieved during insulin infusion did not differ on study days 1 and 4. In contrast, the glucose levels required to stimulate an increase in EPI (2.8 vs. 3.1 mM), glucagon (2.8 vs. 3.2 mM), cortisol (2.4 vs. 2.9 mM), GH (2.6 vs. 3.0 mM), and autonomic hypoglycemic symptoms (2.2 vs. 2.5 mM) were all significantly lower on study day 4 versus study day 1 (P < 0.005–0.05). Basal levels of EPI and cortisol, but not glucagon, GH, or NE also were reduced on the final study day. We conclude that intermittent hypoglycemia can result in attenuation of the hormonal and symptomatic responses to insulin-induced hypoglycemia and may contribute to the defective counterregulatory responses in patients with well-controlled IDDM.
Role of Display Rule Demands and Affective Traits in Emotional Exhaustion among Customer Services

The present study examined the impact of gender, display rule demands, and affective personality traits on emotional exhaustion in a sample of 232 Pakistani customer services representatives of cellular companies and banks. Emotion Work Requirements Scale (Best, Downey, and Jones, 1997) was used to measure display rule demands; emotional exhaustion was measured using Erickson and Ritter's (2001) Emotional Exhaustion Scale; while affectivity was measured through Positive and Negative Affect Schedule (Watson, Clark, and Tellegen, 1988) and Emotional Intelligence Scale (Wong and Law, 2002). Analysis revealed that women employees were significantly higher on emotional exhaustion and hiding negative emotions as compared to their men counterparts. The final hierarchical regression model demonstrated that display rule demands, i.e. hiding negative emotions, negative affectivity, and emotional intelligence were positive predictors of emotional exhaustion whereas positive affectivity turned out to be a negative predictor of emotional exhaustion. Furthermore, Sobel test (Sobel, 1982) indicated that negative affectivity fully mediated the relation between display rule demands of hiding negative emotions and emotional exhaustion. Limitations and suggestions for future studies have been discussed.
Role of Tonically Active Neurons in Primate Caudate in Reward-Oriented Saccadic Eye Movement

Recent studies have suggested that the basal ganglia are essential for reward-oriented behavior. A popular proposal is that the interaction between sensorimotor and reward-related signals occurs in the striatal projection neurons. However, the role of interneurons remains unclear. Using the one-direction-rewarded version of the memory-guided saccade task (1DR), we examined the activity of tonically active neurons (TANs), presumed cholinergic interneurons, in the caudate. Many TANs (73/155, 47.1%) responded, usually with a pause, to a visual cue that indicated both the saccade goal and the presence or absence of reward. For most TANs (44/73, 60.3%), the response was spatially selective (contralateral dominant), but was not modulated by the reward significance. TANs are thus distinct from caudate projection neurons, which have responses to the cue that are both spatially selective and reward contingent, and from midbrain dopamine neurons, which have cue responses that are spatially nonselective and reward contingent. TANs were nonetheless sensitive to the reward schedule: in the all-directions-rewarded version (ADR) compared with 1DR, the cue responses of TANs were smaller, less frequent, and less spatially selective. In 1DR, it would first be detected that reward is not given regularly, and this process would then promote discrimination of individual stimuli in relation to reward. We propose that TANs would contribute to the detection of the context that requires discrimination, whereas dopamine neurons would contribute to the stimulus discrimination. These features of TANs might be explained by their cytoarchitecture, namely, as large aspiny neurons.
In-Class Versus Online Video Lectures

Previous findings suggest some advantages to using an online format to deliver declarative knowledge and to using class time for active learning and discussion. During 4 weeks of an introductory psychology course, students were assigned on alternate weeks to attend one of two lecture formats: in-class lecture or online video lecture with an in-class active learning session. No advantage was found for either format on the basis of quiz scores. Students appreciated the convenience of online lectures but preferred in-class lectures because of the increased ease of maintaining attention in the more structured environment. Attendance, as well as access of online content, decreased during the course of the study, suggesting that hybrid courses may lead to decreases in overall student effort.
Effects of attentional load and ageing on word-stem and word-fragment implicit memory tasks

The joint effects of reduced attention and age on repetition priming in implicit memory tests of word-fragment completion (WFC) and word-stem completion (WSC) were investigated. An attention load during the study phase reduced the extent of repetition priming in the WSC condition but not in WFC. This finding provides support for the view that WSC and WFC involve different processes. However, there was no evidence of an age effect on either of these two types of implicit tasks. The data also revealed an overall significant effect of age and reduced attention on explicit cued recall tasks.
Ineffectiveness of burst suppression therapy in mitigating perioperative cerebrovascular dysfunction. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.

BACKGROUND Cerebral injury is among the most common and disabling complications of open heart surgery. Attempts to provide neuroprotection have yielded conflicting results. We assessed the potential of propofol-induced burst suppression during open heart surgery to provide cerebral protection as determined by postoperative neuropsychologic function. METHODS Two hundred twenty-five patients undergoing valve surgery were randomized to receive either sufentanil or sufentanil plus propofol titrated to electroencephalographic burst suppression. Blinded investigators performed neurologic and neuropsychologic testing at baseline, postoperative day (POD) 1 (neurologic testing only), PODs 5-7, and PODs 50-70. Neuropsychologic tests were compared with the results of 40 nonsurgical patients matched for age and education. RESULTS Electroencephalographic burst suppression was successfully achieved in all 109 propofol patients. However, these patients sustained at least as many adverse neurologic outcomes as the 116 controls: POD 1, 40% versus 25%, P = 0.06; PODs 5-7, -18% versus 8%, P = 0.07; PODs 50-70, -6% versus 6%, P = 0.80. No differences in the incidence of neuropsychologic deficits were detected, with 91% of the propofol patients versus 92% of the control patients being impaired at PODs 5-7, decreasing to 52 and 47%, respectively, by PODs 50-70. No significant differences in the severity of neuropsychologic dysfunction, depression, or anxiety were noted. CONCLUSIONS Electroencephalographic burst suppression surgery with propofol during cardiac valve replacement did not significantly reduce the incidence or severity of neurologic or neuropsychologic dysfunction. The authors' results suggest that neither cerebral metabolic suppression nor reduction in cerebral blood flow reliably provide neuroprotection during open heart surgery. Other therapeutic approaches must be evaluated to address this important medical problem.
Genetic polymorphisms and response to 5-fluorouracil, doxorubicin and cyclophosphamide chemotherapy in breast cancer patients

Clinical resistance to chemotherapy is one of the major problems in breast cancer treatment. In this study we analyzed possible impact of 22 polymorphic variants on the treatment response in 324 breast cancer patients. Selected genes were involved in FAC chemotherapy drugs transport (ABCB1, ABCC2, ABCG2, SLC22A16), metabolism (CYP1B1, CYP2C19, GSTT1, GSTM1, GSTP1, TYMS, MTHFR, DPYD), drug-induced damage repair (ERCC1, ERCC2, XRCC1) and involved in regulation of DNA damage response and cell cycle control (ATM, TP53). Apart from preexisting metastases three polymorphic variants were independent prognostic high risk factors of lack of response to FAC chemotherapy. Our results showed that the response to treatment depended of the variability in genes engaged in drugs’ transport (ABCC2 c.-24C>T, ABCB1 p.Ser893Ala/Thr) and in DNA repair machinery (ERCC2 p.Lys751Gln). Furthermore, the growing number of high-risk genotypes was reflected in gradual increase in risk of the non-responsiveness to treatment- from OR 2.68 for presence of two genotypes to OR 9.93 for carriers of all three negative genotypes in the group of all patients. Similar gene-dosage effect was observed in the subgroup of TNBCs. Also, TFFS significantly shortened with the increasing number of high-risk genotypes, with median of 54.4 months for carriers of one variant, to 51.5 and 34.9 months for the carriers of two and three genotypes, respectively. Our results demonstrate that results of cancer treatment are the effect of many clinical and genetic factors. It seems that multifactorial polymorphic models could be a potentially useful tool in personalization of cancer therapies. The novelty in our model is the over representation of triple negative breast cancer (TNBC) patients among the carriers of all unfavorable polymorphic variants. This finding contributes to the elucidation of the mechanisms of drug resistance in this subgroup of breast cancer patients.
Extensions of the parametric families of divergences used in statistical inference

t = 1 with nonzero second derivative at the point t = 1. Using this method we introduce several extensions of the LeCam, power, ´ a and Matusita divergences. The extended families are shown to connect smoothly these divergences with the Kullback divergence or they connect various pairs of these particular divergences themselves. We investigate also the metric properties of divergences from these extended families.
Fundamental Limits of Caching With Secure Delivery

Caching is emerging as a vital tool for alleviating the severe capacity crunch in modern content-centric wireless networks. The main idea behind caching is to store parts of the popular content in end-users' memory and leverage the locally stored content to reduce peak data rates. By jointly designing content placement and delivery mechanisms, recent works have shown order-wise reduction in transmission rates in contrast to traditional methods. In this paper, we consider the secure caching problem with the additional goal of minimizing information leakage to an external wiretapper. The fundamental cache memory versus transmission rate tradeoff for the secure caching problem is characterized. Rather surprisingly, these results show that security can be introduced at a negligible cost, particularly for large number of files and users. It is also shown that the rate achieved by the proposed caching scheme with secure delivery is within a constant multiplicative factor from the information-theoretic optimal rate for almost all parameter values of practical interest.
Modeling the Relationships among Organizational Commitment and Its Outcome and Antecedents Using Career Stage as a Moderator

This study proposed a theoretical model for examining the process of turnover intentions and organizational commitment (OC) using career stage as a moderator. In the model, turnover intentions are influenced directly by OC and procedural justice, while procedural justice and leader-member exchange (LMX) influence turnover intentions indirectly through the mediation of OC. The relationships of the proposed model are moderated by a career stage moderator, which combines age and employee tenure. The moderating effects were simultaneously examined using data from staff in Taiwanese hospitals. The influences of OC and procedural justice on turnover intentions are found to be similar for the initial and mature stage groups, while the influence of procedural justice on OC is stronger for the initial stage group than the mature stage group. Finally, LMX exerts a stronger influence on OC for the mature stage group than for the initial stage group. The implications of the above findings are discussed.
Phase problem in the B-site ordering of La2CoMnO6: impact on structure and magnetism.

Epitaxial double perovskite La2CoMnO6 (LCMO) films were grown by metalorganic aerosol deposition on SrTiO3(111) substrates. A high Curie temperature, TC = 226 K, and large magnetization close to saturation, MS(5 K) = 5. 8μB/f.u. , indicate a 97% degree of B-site (Co,Mn) ordering within the film. The Co/Mn ordering was directly imaged at the atomic scale by scanning transmission electron microscopy with energy-dispersive X-ray spectroscopy (STEM-EDX). Local electron-energy-loss spectroscopy (EELS) measurements reveal that the B-sites are predominantly occupied by Co(2+) and Mn(4+) ions in quantitative agreement with magnetic data. Relatively small values of the (1/2 1/2 1/2) superstructure peak intensity, obtained by X-ray diffraction (XRD), point out the existence of ordered domains with an arbitrary phase relationship across the domain boundary. The size of these domains is estimated to be in the range 35-170 nm according to TEM observations and modelling the magnetization data. These observations provide important information towards the complexity of the cation ordering phenomenon and its implications on magnetism in double perovskites, and similar materials.
Sex differences in two fundamental cognitive domains: Empathizing and systemizing in children and adults.

Prior research indicates that, on average, females are superior at tasks concerned with the social cognitive domain, whereas males are superior at tasks concerned with physical cognitive domains. The empathizing-systemizing (E-S) theory explains these differences by proposing two independent cognitive drives: empathizing and systemizing. The present study explores sex differences and the relationship between these cognitive domains. Participants were 267 elementary school children (mean age = 9.8) and 102 university students (mean age = 20.7) who performed two tasks: the Eyes test and the intuitive physics test. Results showed that females scored higher than males on the Eyes test in both participant groups, whereas no marked sex differences appeared in the intuitive physics test. Distributions of cognitive styles, derived from performance differences in the two tasks, showed marked sex differences, and correlations between performances in the two tasks were near zero in both groups, were consistent with .
From trust to accountability: Negotiating media performance in the Netherlands, 1987—2007

Over the past decade media and journalistic performance in many liberal democracies has come under criticism, increasingly leading to a waning trust among politicians and the public. Based on a triangulation of methods this article attempts to obtain a better understanding of the themes and underlying discourse in this critique and how media and journalists responded to the subsequent pressures on their performance in terms of accountability and responsiveness over a period of 20 years in the Netherlands.