Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of M1 and M2 Macrophages in Prostate Cancer in relation to Extracapsular Tumor Extension and Biochemical Recurrence after Radical Prostatectomy

Introduction. The aim of our work was to investigate the causal connection between M1 and M2 macrophage phenotypes occurrence and prostate cancer, their correlation with tumor extension (ECE), and biochemical recurrence (BR). Patient and Methods. Clinical and pathological data were prospectively gathered from 93 patients treated with radical prostatectomy. Correlations of commonly used variables were evaluated with uni- and multivariate analysis. The relationship between M1 and M2 occurrence and BR was also assessed with Kaplan-Meier survival analysis. Results. Above all in 63.4% there was a M2 prevalence. M1 occurred more frequently in OC disease, while M2 was more represented in ECE. At univariate analysis biopsy and pathologic GS and M2 were statistically correlated with ECE. Only pathologic GS and M2 confirmed to be correlated with ECE. According to macrophage density BCR free survival curves presented a statistically significant difference. When we stratified our population for M1 and M2,we did not find any statistical difference among curves. At univariate analysis GS, pTNM, and positive margins resulted to be significant predictors of BCR, while M1 and M2 did not achieve the statistical significance. At multivariate analysis, only GS and pathologic stage were independent predictors of BR. Conclusion. In our study patients with higher density of M count were associated with poor prognosis; M2 phenotype was significantly associated with ECE.
Exploring career experiences of Swedish professional handball players: Consolidating first-hand information into an empirical career model

The study was aimed at developing the empirical career model of Swedish professional handball players by means of exploring their career experiences in athletic and non-athletic developments through the lens of the holistic athletic career model. Eighteen Swedish professional handball players (nine men and nine women), who had recently terminated or were finishing their careers took part in semi-structured interviews about their careers from the beginning to the end with an interest in both athletic and non-athletic developments. Thematic analysis initially focused on identifying the handball career structure (i.e. stages and sub-stages). Then, the interviews were analysed inductively to identify shared themes in the players’ experiences relevant to each career stage. These themes were incorporated in the relevant stages, and the empirical career model of Swedish professional handball players (further – the empirical model) was finalised. The empirical model describes careers of Swedish handball players as having four athletic stages – initiation, development (with three sub-stages), mastery (with four sub-stages), and discontinuation – complemented by players’ psychological, psychosocial, academic/vocational, and financial developments. Each stage is also aligned with age markers and contains themes describing players’ career experiences from the holistic perspective. The empirical model contributes to contextualised career research and serves as a basis for developing career-long psychological support services in Swedish handball including player/coach/parent education organised by the Swedish Handball Federation.
Aeromagnetic Map Constrains Jurassic–Early Cretaceous Synrift, Break Up, and Rotational Seafloor Spreading History in the Gulf of Mexico

We present a reduced-to-pole, total magnetic intensity map derived from merged aeromagnetic surveys in and around the Gulf of Mexico. Most of the deep central Gulf crust has a magnetic pattern of orthogonally intersecting features similar to, and interpreted as, fracture zones and ridge segments of oceanic crust formed by seafloor spreading. This spreading or drift phase occurred after the primary synrift phase of continental stretching across the greater Gulf of Mexico region, and thus the ocean crust rests within a broader zone of stretched continental crust with Yucatán, western Florida, the southern USA, and eastern Mexico forming the surrounding continental margins. We identify three regional magnetic anomaly trends that can be used to constrain the Gulf of Mexico’s Late Jurassic through earliest Cretaceous spreading history. A central magnetic anomaly trend is interpreted to accord with the later increments and cessation of seafloor spreading, for which a stage pole of rotation is estimated. Two flanking magnetic anomaly trends to the north and south of the central one, respectively, occur just basinward from the inferred depositional limits of autochthonous Callovian-Early Oxfordian salt. These anomalies appear to define the landward limits of oceanic crust in the northern and southern Gulf, and probably lie in crust that is medial or Late Oxfordian in CO PY RIG HT 20 16 G CS SE PM
Weighted-damped Approximate Message Passing for compressed sensing

Approximate Message Passing (AMP) simplified from Loopy Belief Propagation (LBP), is an important algorithm for sparse signal reconstruction in Compressed Sensing (CS). To improve the performance of current AMP algorithms, a weighted-damped AMP algorithm (WDAMP) is derived from a weighted version of BP that adopt probability damping technique. Simulation results show that WDAMP outperforms normal AMP for both 1-D and 2-D signal reconstruction. For 1-D signal reconstruction, probability damping brings most of the improvement. For 2-D signal reconstruction, weighting technique makes the major contribution. In summary, WDAMP outperforms conventional AMP.
Corpus Callosum Length by Gestational Age as Evaluated by Fetal MR Imaging

SUMMARY: Although suspected corpus callosum abnormality is a common indication for fetal MR imaging, biometric data specific to MR imaging are sparse. We sought to characterize growth in corpus callosum length by EGA with fetal MR imaging. Corpus callosum segments were assessed and overall corpus callosum length was measured and plotted against the EGA for 68 anatomically normal fetal brains ranging in EGA from 18.5 to 37.7 weeks, and linear and polynomial regression models were calculated. The body of the corpus callosum was identified in all fetuses, followed in frequency by the splenium (91.2%), genu (85.3%), and rostrum (32.4%). Measurements of corpus callosum length by MR imaging were in agreement with values established by sonography. A second-degree polynomial function was the best fit for callosal length by EGA. Understanding this normal growth pattern may enhance detection of subtle growth abnormalities.
10 year follow up study of mortality among users of hostels for homeless people in Copenhagen

Abstract Objectives To investigate mortality among users of hostels for homeless people in Copenhagen, and to identify predictors of death such as conditions during upbringing, mental illness, and misuse of alcohol and drugs. Design Register based follow up study. Setting Two hostels for homeless people in Copenhagen, Denmark Participants 579 people who stayed in one hostel in Copenhagen in 1991, and a representative sample of 185 people who stayed in the original hostel and one other in Copenhagen. Main outcome measure Cause specific mortality. Results The age and sex standardised mortality ratio for both sexes was 3.8 (95% confidence interval 3.5 to 4.1); 2.8 (2.6 to 3.1) for men and 5.6 (4.3 to 6.9) for women. The age and sex standardised mortality ratio for suicide for both sexes was 6.0 (3.9 to 8.1), for death from natural causes 2.6 (2.3 to 2.9), for unintentional injuries 14.6 (11.4 to 17.8), and for unknown cause of death 62.9 (52.7 to 73.2). Mortality was comparatively higher in the younger age groups. It was also significantly higher among homeless people who had stayed in a hostel more than once and stayed fewer than 11 days, compared with the rest of the study group. Risk factors for early death were premature death of the father and misuse of alcohol and sedatives. Conclusion Homeless people staying in hostels, particularly young women, are more likely to die early than the general population. Other predictors of early death include adverse experiences in childhood, such as death of the father, and misuse of alcohol and sedatives.
Feasibility and Conceptualization of an e-Mental Health Treatment for Depression in Older Adults: Mixed-Methods Study

Background Depression is one of the most common mental disorders in older adults. Unfortunately, it often goes unrecognized in the older population. Objective The aim of this study was to identify how Web-based apps can recognize and help treat depression in older adults. Methods Focus groups were conducted with mental health care experts. A Web-based survey of 56 older adults suffering from depression was conducted. Qualitative interviews were conducted with 2 individuals. Results Results of the focus groups highlighted that there is a need for a collaborative care platform for depression in old age. Findings from the Web-based study showed that younger participants (aged 50 to 64 years) used electronic media more often than older participants (aged 65 years and older). The interviews pointed in a comparable direction. Conclusions Overall, an e-mental (electronic mental) health treatment for depression in older adults would be well accepted. Web-based care platforms should be developed, evaluated, and in case of evidence for their effectiveness, integrated into the everyday clinic.
Differentially Private Data Releasing for Smooth Queries with Synthetic Database Output

We consider accurately answering smooth queries while preserving differential privacy. A query is said to be $K$-smooth if it is specified by a function defined on $[-1,1]^d$ whose partial derivatives up to order $K$ are all bounded. We develop an $\epsilon$-differentially private mechanism for the class of $K$-smooth queries. The major advantage of the algorithm is that it outputs a synthetic database. In real applications, a synthetic database output is appealing. Our mechanism achieves an accuracy of $O (n^{-\frac{K}{2d+K}}/\epsilon )$, and runs in polynomial time. We also generalize the mechanism to preserve $(\epsilon, \delta)$-differential privacy with slightly improved accuracy. Extensive experiments on benchmark datasets demonstrate that the mechanisms have good accuracy and are efficient.
Call-Stack Coverage for GUI Test Suite Reduction

Graphical user interfaces (GUIs) are used as front ends to most of today's software applications. The event-driven nature of GUIs presents new challenges for testing. One important challenge is test suite reduction. Conventional reduction techniques/tools based on static analysis are not easily applicable due to the increased use of multilanguage GUI implementations, callbacks for event handlers, virtual function calls, reflection, and multithreading. Moreover, many existing techniques ignore code in libraries and fail to consider the context in which event handlers execute. Consequently, they yield GUI test suites with seriously impaired fault-detection abilities. This paper presents a reduction technique based on the call-stack coverage criterion. Call stacks may be collected for any executing program with very little overhead. Empirical studies in this paper compare reduction based on call-stack coverage to reduction based on line, method, and event coverage, including variations that control for the size and optional consideration of library methods. These studies show that call-stack-based reduction provides unique trade-offs between the reduction in test suite size and the loss of fault detection effectiveness, which may be valuable in practice. Additionally, an analysis of the relationship between coverage requirements and fault-revealing test cases is presented.
Testing for a Unit Root in the Asymmetric Nonlinear Smooth Transition Framework

This paper proposes a simple testing procedure to detect the presence of nonlinear but global stationary logistic smooth transition autoregressive processes. This testing procedure nests the one developed by Kapetanios et al. (2003) that accommodates specifically the alternative of a global stationary ESTAR process. The present work makes a threefold contribution to the literature. First, it derives the limiting nonstandard distribution of the proposed test. Second, the paper finds via Monte Carlo simulations that under the alternative of a globally stationary LSTAR process, this new test has better power than a standard Dickey-Fuller test. Third, an empirical application of the test to real exchange data in OECD countries rejects the null of a unit root more often than a simple Dickey-Fuller. This finding provides more evidence in favor of nonlinear PPP mean-reversion.
The Experience of Posttraumatic Growth for People With Spinal Cord Injury

The purpose of this qualitative study was to explore the characteristics of posttraumatic growth for people with spinal cord injury. In this study, we intentionally selected people exhibiting evidence of posttraumatic growth to capture distinctive characteristics of the phenomenon. A thematic analysis was used to examine the narratives of life experiences before and after spinal cord injury. The three most salient themes of posttraumatic growth were identified: experience of meaningful family relationships, experience of meaningful engagement, and appreciation of life. Further investigation into the experience of posttraumatic growth is necessary in the future for a better understanding of the phenomena.
Interpersonal Realizations of Pedagogic Discourse in Indonesian EFL Classrooms

This paper describes the lexicogrammatical realizations of interpersonal meaning in English as a Foreign Language (EFL) classrooms in Indonesian university context. The realizational grammatical patterns are presented using MOOD system in systemic functional linguistics (SFL). The data of this study were three EFL classrooms taken from three English departments in Indonesian universities in Semarang City. Data analyses were done by transcribing the lectures and then divided them into clauses from which the lexicogrammatical realizations of pedagogic MOOD were identified and classified based on MOOD System as suggested by Halliday & Matthiessen in SFL perspectives. The results of the study show that interpersonally, the clauses used in the EFL classrooms are predominated by declarative clause, interrogative clause, and imperative clause. The predominance of declarative clause is influenced by the teacher-centered teaching method used in the classrooms. This method poses lecturer as an expert and students as novice. In this situation, lecturer dominates in giving information about the learning materials. Besides, interrogative clause is also used by lecturer to know the students’ understanding of the learning materials. Finally, imperative clause is also used to ask students to do something relating to the understanding of the learning materials.
Addendum: “The Dynamics of M15: Observations of the Velocity Dispersion Profile and Fokker-Planck Models” (ApJ, 481, 267 [1997])

It has recently come to our attention that there are axis scale errors in three of the figures of Dull et al. (1997, hereafter D97). D97 presented Fokker-Planck models for the collapsed-core globular cluster M15 that include a dense, centrally concentrated population of neutron stars and massive white dwarfs, but do not include a central black hole. In this Addendum, we present corrected versions of Figures 9, 10, and 12, and an expanded version of Figure 6. This latter figure, which shows the full run of the velocity dispersion profile, indicates that the D97 model predictions are in good agreement with the moderately rising HST-STIS velocity dispersion profile for M15 reported by Gerssen et al. (2002, astro-ph/0209315). Thus, a central black hole is not required to fit the new STIS velocity measurements, provided that there is a sufficient population of neutron stars and massive white dwarfs. This conclusion is consistent with the findings of Gerssen et al. (2002, astro-ph/0210158), based on a reapplication of their Jeans equation analysis using the corrected mass-to-light profile (Figure 12) for the D97 models.
Brand Management and Business Performance in Mexican Small Business

Brand management is a relatively new topic in marketing literature and it is considered by several researchers, academics and professionals, as one of the most important business strategies that allow not only a significant growth of the business performance of small enterprises, but also their continuity in the market where they participate. Similarly, brand management has also been analyzed and discussed at the core of enterprises and there are relatively few investigations that focus on small enterprises, and there are even less researches carried out in developing countries. For these reasons, the main goal of this empirical research is the analysis and discussion of the effects of brand management on the level of business performance in small enterprises, by using a sample of 300 small firms and by implementing a model of structural equations of second order, that can provide a deeper understanding of the current relation between brand management and business performance. The results obtained show that brand management has a positive and significant in the level of business performance in small enterprises.
Rendering stiffer walls: a hybrid haptic system using continuous and discrete time feedback

Instability in conventional haptic rendering destroys the perception of rigid objects in virtual environments. Inherent limitations in the conventional haptic loop restrict the maximum stiffness that can be rendered. In this paper we present a method to render virtual walls that are much stiffer than those achieved by conventional techniques. By removing the conventional digital haptic loop and replacing it with a part-continuous and part-discrete time hybrid haptic loop, we were able to render stiffer walls. The control loop is implemented as a combinational logic circuit on an field-programmable gate array. We compared the performance of the conventional haptic loop and our hybrid haptic loop on the same haptic device, and present mathematical analysis to show the limit of stability of our device. Our hybrid method removes the computer-intensive haptic loop from the CPU—this can free a significant amount of resources that can be used for other purposes such as graphical rendering and physics modeling. It is our hope that, in the future, similar designs will lead to a haptics processing unit (HPU).
Comparison of Short-Term Clinical Outcomes of Hook Plate and Continuous Loop Double Endobutton Fixations in Acute Acromioclavicular Joint Dislocation.

Background This study was conducted to evaluate the clinical outcomes of the acromioclavicular joint (ACJ) fixation with hook plate (HP) and continuous loop double endobutton fixation (CLDE) in the treatment of acute ACJ dislocation. Methods This retrospective study was conducted on eight patients with HP and nine patients with CLDE fixations for acute ACJ dislocations. The subjects were evaluated by various criteria, including disabilities of the Arm, Shoulder, and Hand (DASH), American Shoulder and Elbow Surgeons Standardized Shoulder Assessment (ASES), University of California, Los Angeles (UCLA) shoulder rating scale, Shoulder Constant score, Simple Shoulder Test (SST), and coracoclavicular (CC) distance. Results The differences between the mean scores of the visual analog scale for pain, DASH, ASES, UCLA shoulder rating scale, and Shoulder Constant, and SST were statistically significant in favor of the CLDE group. Mean difference of CC distance was 8.6±0.9 mm in the HP group; however, it was 11.6±1.2 mm in the CLDE group. The operation time was shorter in the HP fixation, compared to that in the CLDE fixation (51±13.3 versus 105±9.7 min; P<0.001 and P=0.008). There were six concomitant subacromial erosions and osteoarthritis in the ACJ of the HP group. Conclusion The CLDE fixation was reported with better clinical outcomes than HP fixation; however, it was a technically demanding procedure. The HP maintained the CC distance better than CLDE with a technically easy application. The HP requires a second surgery for the removal and development of subacromial erosion and osteoarthritis of the ACJ that can be regarded as major concerns.
Spiky strings and giant magnons on S5

Recently, classical solutions for strings moving in AdS5 × S5 have played an important role in understanding the AdS/CFT correspondence. A large set of them were shown to follow from an ansatz that reduces the solution of the string equations of motion to the study of a well-known integrable 1-d system known as the Neumann-Rosochatius (NR) system. However, other simple solutions such as spiky strings or giant magnons in S5 were not included in the NR ansatz. We show that, when considered in the conformal gauge, these solutions can be also accomodated by a version of the NR-system. This allows us to describe in detail a giant magnon solution with two additional angular momenta and show that it can be interpreted as a superposition of two magnons moving with the same speed. In addition, we consider the spin chain side and describe the corresponding state as that of two bound states in the infinite SU(3) spin chain. We construct the Bethe ansatz wave function for such bound state.
On the origin of the Fibonacci Sequence

Herein we investigate the historical origins of the Fibonacci numbers. After emphasising the importance of these numbers, we examine a standard conjecture concerning their origin only to demonstrate that it is not supported by historical chronology. Based on more recent findings, we propose instead an alternative conjecture through a close examination of the historical and historical/mathematical circumstances surrounding Leonardo Fibonacci and relate these circumstances to themes in medieval and ancient history. Cultural implications and historical threads of our conjecture are also examined in this light.
Gender differences in writing complex sentences: A case study of Indonesian EFL students

This study investigated the Indonesian EFL students' proficiency in writing complex sentences and explored the gender differences in their writing products. Thirty-eight (38) high school students – 19 males and 19 females – were instructed to write a narrative account of the silent movie, The Pear Film, immediately after watching it. The result of the study revealed that the students' production of sentence complexity exhibited a sequential degree of difficulty from simple sentence (1 T-unit) to more complex sentences (2 T-units or 3 T-units). Female students had higher frequencies in producing T-units, and they also exhibited a more powerful imagination and creativity in building complex sentences. However, the males outnumbered the females in the production of lexical variety. This indicated that longer sentences are not always directly related to the breadth of vocabulary knowledge.