Miracle-dz/UniFAR-FTUs huggingface dataset:
Bidirectional Expansion For Keyword Search on Graph Databases

Relational, XML and HTML data can be represented as graphs with entities as nodes and relationships as edges. Text is associated with nodes and possibly edges. Keyword search on such graphs has received much attention lately. A central problem in this scenario is to efficiently extract from the data graph a small number of the "best" answer trees. A Backward Expanding search, starting at nodes matching keywords and working up toward confluent roots, is commonly used for predominantly text-driven queries. But it can perform poorly if some keywords match many nodes, or some node has very large degree.In this paper we propose a new search algorithm, Bidirectional Search, which improves on Backward Expanding search by allowing forward search from potential roots towards leaves. To exploit this flexibility, we devise a novel search frontier prioritization technique based on spreading activation. We present a performance study on real data, establishing that Bidirectional Search significantly outperforms Backward Expanding search.
Phase Ib Study of Glasdegib, a Hedgehog Pathway Inhibitor, in Combination with Standard Chemotherapy in Patients with AML or High-Risk MDS

Purpose: This open-label, multicenter, dose-finding, phase Ib study (NCT01546038) evaluated the safety, pharmacokinetics, pharmacodynamics, and clinical activity of the novel Hedgehog pathway Smoothened inhibitor glasdegib (PF-04449913) in patients (N = 52) with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). Experimental Design: Glasdegib 100 or 200 mg was administered orally, once daily in 28-day cycles, in combination with low-dose cytarabine (arm A) or decitabine (arm B) to newly diagnosed patients considered not suitable for standard induction chemotherapy, and in combination with cytarabine/daunorubicin (arm C) to fit patients. The study followed a standard 3+3 dose-escalation design. The primary endpoint was dose-limiting toxicity (DLT). Ten additional patients were enrolled in expansion cohorts of arms A (n = 23) and C (n = 22) to confirm the recommended phase II dose (RP2D). Results: No DLTs were observed in arms A and B; 1 DLT (grade 4 neuropathy) occurred in arm C. The most common treatment-related nonhematologic adverse events were mostly grades 1 and 2 in all arms. Muscle spasms, dysgeusia, and alopecia were generally mild. Overall, 16 patients (31%) achieved a complete remission (CR)/CR with incomplete blood count recovery. Note that 100 mg daily was selected as the RP2D for glasdegib in combination with standard chemotherapies in the absence of an estimated MTD in this setting. Conclusions: Treatment with glasdegib in combination with standard chemotherapy was generally well-tolerated and consistent with prior findings, warranting further evaluation of glasdegib-based combinations in patients with AML or high-risk MDS. Clin Cancer Res; 24(10); 2294–303. ©2018 AACR.
Cardiolipin synthase A colocalizes with cardiolipin and osmosensing transporter ProP at the poles of Escherichia coli cells

Osmosensing by transporter ProP is modulated by its cardiolipin (CL)‐dependent concentration at the poles of Escherichia coli cells. Other contributors to this phenomenon were sought with the BACterial Two‐Hybrid System (BACTH). The BACTH‐tagged variants T18‐ProP and T25‐ProP retained ProP function and localization. Their interaction confirmed the ProP homo‐dimerization previously established by protein crosslinking. YdhP, YjbJ and ClsA were prominent among the putative ProP interactors identified by the BACTH system. The functions of YdhP and YjbJ are unknown, although YjbJ is an abundant, osmotically induced, soluble protein. ClsA (CL Synthase A) had been shown to determine ProP localization by mediating CL synthesis. Unlike a deletion of clsA, deletion of ydhP or yjbJ had no effect on ProP localization or function. All three proteins were concentrated at the cell poles, but only ClsA localization was CL‐dependent. ClsA was shown to be N‐terminally processed and membrane‐anchored, with dual, cytoplasmic, catalytic domains. Active site amino acid replacements (H224A plus H404A) inactivated ClsA and compromised ProP localization. YdhP and YjbJ may be ClsA effectors, and interactions of YdhP, YjbJ and ClsA with ProP may reflect their colocalization at the cell poles. Targeted CL synthesis may contribute to the polar localization of CL, ClsA and ProP.
Guillain‐Barré syndrome in France: a nationwide epidemiological analysis based on hospital discharge data (2008–2013)

Guillain‐Barré syndrome (GBS) is potentially life threatening and typically occurs after an infection. No detailed information is available concerning the epidemiological characteristics of GBS in France. We estimated age‐ and sex‐specific incidence rates (IRs) based on a French nationwide hospital discharge database. All patients hospitalized for GBS between 2008 and 2013 were identified by International Classification of Diseases‐10 code G61.0 as principal diagnosis. Patients previously hospitalized for GBS in 2006 and 2007 were excluded. Sensitivity analyses were performed by considering alternative case definitions, based on more restrictive sets of codes. A total of 9,391 patients were identified, leading to an overall crude IR of 2.42 per 100,000 person‐years (world standardized IR = 2.00). IRs increased with age, reaching a peak in the 70–79‐year age group. IR was 46% higher in men than in women, and 44% higher in winter than in summer. In children, the highest IR was observed at the age of 2 years. These patterns were not modified by the use of alternative case definitions. This French nationwide study showed similar GBS epidemiological patterns in adults to those reported in other countries. We also report a childhood incidence peak around the age of 2 years, as previously observed in Latin American and Chinese populations.
Large Scale Simulation of Dendritic Growth in Pure Undercooled Melt by Phase-field Model

In this study we presented a double-grid method for efficient computation of complex dendritic pattern evolving in a large scale solidifying system of pure undercooled melt. The method, which is based on the large difference in phase-field diffusivity and thermal diffusivity in pure material, enables us to use a large time step. The phase field was calculated adaptively only on the grids within the interfacial region and also the thermal field was calculated only within the thermal boundary layer. The computation showed that the complex dendritic patterns with well-developed tertiary arms can be obtained even in a personal computer with a moderate memory space. The computational efficiency of this method, the competitive growth and coarsening of the secondary arms and the tertiary branching from secondary arms were discussed.
Sizing of IPM Generator for a Single Point Absorber Type Wave Energy Converter

In this paper, a wave energy converter (WEC) is designed for a wave climate condition and its interior permanent magnet (IPM) generator is dimensioned for minimum life cycle cost (LCC). The single point absorber movement is simulated and the harnessed annual energy is determined to be 325 MWh. Possible IPM generator sizes are investigated using finite element calculations. Tradeoffs between the generator cost and the annual energy efficiency is performed in order to find the best economical solution. For the economical evaluation, the net present value method is utilized in order to obtain the LCC of the electric generation system of the WEC. Increasing the axial length of the machine 1.6 times results in the lowest LCC, with a $2.5\%$ efficiency increase, which means an increment of approximately 1000 € in the investment cost. Despite the higher investment cost, the LCC of the WEC generator decreases from 8070 € to 6450 €, due to the lower losses.
Extremism, religion and psychiatric morbidity in a population-based sample of young men

Background There is growing risk from terrorism following radicalisation of young men. It is unclear whether psychopathology is associated. Aims To investigate the population distribution of extremist views among UK men. Method Cross-sectional study of 3679 men, 18–34 years, in Great Britain. Multivariate analyses of attitudes, psychiatric morbidity, ethnicity and religion. Results Pro-British men were more likely to be White, UK born, not religious; anti-British were Muslim, religious, of Pakistani origin, from deprived areas. Pro- and anti-British views were linearly associated with violence (adjusted odds ratio (OR) = 1.51, 95% CI 1.38–1.64, P<0.001, adjusted OR = 1.33, 95% CI 1.13–1.58, P<0.001, respectively) and negatively with depression (adjusted OR = 0.72, 95% CI 0.61–0.85, P<0.001, adjusted OR = 0.64, 95% CI 0.48–0.86, P = 0.003, respectively). Conclusions Men at risk of depression may experience protection from strong cultural or religious identity. Antisocial behaviour increases with extremism. Religion is protective but may determine targets of violence following radicalisation.
Stress and suicidal ideation among adolescents having academic difficulty

Background and Objectives: Academically typically achieving adolescents were compared with students having academic difficulty on stress and suicidal ideas. Materials and Methods: In a cross-sectional study, 75 academically typically achieving adolescents were compared with 105 students with academic difficulty and 52 students with specific learning disability (SLD). Academic functioning was assessed using teacher's screening instrument, intelligence quotient, and National Institute of Mental Health and Neurosciences index for SLD. Stress and suicidal ideas were assessed using general health questionnaire, suicide risk-11, and Mooney Problem Checklist (MPC). Appropriate statistical methods were applied. Results: Three groups were comparable on age, gender, mother's working status, being only child, nuclear family, self-reported academic decline, and type of school. About half of adolescents reported psychological problems on General Health Questionnaire (mean score >3 in all the groups). Academically typically achieving adolescents showed higher stressors in peer relationships, planning for future and suicidal ideation compared to adolescents with academic difficulty. Adolescents face stress regarding worry about examinations, family not understanding what child has to do in school, unfair tests, too much work in some subjects, afraid of failure in school work, not spending enough time in studies, parental expectations, wanting to be more popular, worried about a family member, planning for the future, and fear of the future. Significant positive correlation was seen between General Health Questionnaire scores and all four subscales of MPC. Suicidal ideas showed a negative correlation with MPC. Interpretations and Conclusions: Adolescents experience considerable stress in multiple areas irrespective of their academic ability and performance. Hence, assessment and management of stress among adolescents must extend beyond academic difficulties.
Reinforcing rubber with carbon nanotubes

We suggest a new reinforcing mechanism for carbon nanotube (CNT)/rubber compounds, based on a comparison of CNT reinforcement of natural rubber (NR) with that by carbon black (CB). The mechanical properties of the NR/CNT compounds were significantly higher, but the amount of bound rubber, an indication of the level of filler-rubber interaction, was lower than with CB. Moreover, the CNT-filled compounds showed a greater degree of strain-softening (Payne effect) and stress-softening (Mullins effect) and higher permanent set than the CB-filled compounds, indicating weaker bonding. In scanning electron microscope studies on cryogenically-fractured surfaces, the CNT bundles were seen to protrude out of the surface when the sample was stretched and slid back in when the deformation was removed. We infer that interfacial interactions between CNT and NR are weak in comparison with the relatively strong adhesion between rubber and CB, as indicated by the high amount of bound rubber in that case. Thus, reinforcement by CNTs is attributed to their large aspect ratio and physical entanglement with rubber molecules, rather than to strong interfacial interaction. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Role‐play virtual worlds for teaching object‐oriented design: the ViRPlay development experience

The use of game technology for building virtual learning environments is intended to improve the motivation and engagement of the student, borrowing such properties from their entertaining counterparts. Nevertheless, wrapping pedagogical contents in a virtual environment is no simple achievement, and requires a rigorous process of designing and validating the metaphors and mechanics included in the virtual learning system. In this paper we describe such design process exemplified in the construction of consecutive versions of ViRPlay, a 3D role play virtual environment for teaching object‐oriented design. We show how main mechanics were transferred from experiments in the real world and how such mechanics were evolved based on empirical evaluations. Copyright © 2011 John Wiley & Sons, Ltd.
TYPLEX® Chelate, a novel feed additive, inhibits Campylobacter jejuni biofilm formation and cecal colonization in broiler chickens

ABSTRACT Reducing Campylobacter spp. carriage in poultry is challenging, but essential to control this major cause of human bacterial gastroenteritis worldwide. Although much is known about the mechanisms and route of Campylobacter spp. colonization in poultry, the literature is scarce on antibiotic‐free solutions to combat Campylobacter spp. colonization in poultry. In vitro and in vivo studies were conducted to investigate the role of TYPLEX® Chelate (ferric tyrosine), a novel feed additive, in inhibiting Campylobacter jejuni (C. jejuni) biofilm formation and reducing C. jejuni and Escherichia coli (E. coli) colonization in broiler chickens at market age. In an in vitro study, the inhibitory effect on C. jejuni biofilm formation using a plastic bead assay was investigated. The results demonstrated that TYPLEX® Chelate significantly reduces biofilm formation. In an in vivo study, 800 broilers (one d old) were randomly allocated to 4 dietary treatments in a randomized block design, each having 10 replicate pens with 20 birds per pen. At d 21, all birds were challenged with C. jejuni via seeded litter. At d 42, cecal samples were collected and tested for volatile fatty acid (VFA) concentrations and C. jejuni and E. coli counts. The results showed that TYPLEX® Chelate reduced the carriage of C. jejuni and E. coli in poultry by 2 and 1 log10 per gram cecal sample, respectively, and increased cecal VFA concentrations. These findings support TYPLEX® Chelate as a novel non‐antibiotic feed additive that may help produce poultry with a lower public health risk of Campylobacteriosis.
Twisting-Rate-Controlled 125 μm Cladding Randomly Coupled Single-Mode 12-Core Fiber

A multicore fiber design with more than 10 coupled cores is investigated numerically and experimentally. It is revealed that a randomly coupled 12-core structure with a square lattice core arrangement can be realized within a 125 μm cladding by employing fiber twisting of more than a few π rad/m. A 125 μm-clad twisting-rate-controlled 12-core fiber is then fabricated and a relative core density of 12 compared with conventional single-mode fiber is achieved while maintaining a low spatial mode dispersion characteristic of 8.4 ps/√km at 1550 nm. Finally, we experimentally evaluated the performance of 12 spatial channels by conducting a 24 × 24 MIMO transmission experiment.
Improving Docker Registry Design Based on Production Workload Analysis

Containers offer an efficient way to run workloads as independent microservices that can be developed, tested and deployed in an agile manner. To facilitate this process, container frameworks offer a registry service that enables users to publish and version container images and share them with others. The registry service plays a critical role in the startup time of containers since many container starts entail the retrieval of container images from a registry. To support research efforts on optimizing the registry service, large-scale and realistic traces are required. In this paper, we perform a comprehensive characterization of a large-scale registry workload based on traces that we collected over the course of 75 days from five IBM data centers hosting production-level registries. We present a trace replayer to perform our analysis and infer a number of crucial insights about container workloads, such as request type distribution, access patterns, and response times. Based on these insights, we derive design implications for the registry and demonstrate their ability to improve performance. Both the traces and the replayer are open-sourced to facilitate further research.
Atomic Norm Denoising-Based Joint Channel Estimation and Faulty Antenna Detection for Massive MIMO

We consider joint channel estimation and faulty antenna detection for massive multiple-input multiple-output systems operating in time-division duplexing mode. For systems with faulty antennas, we show that the impact of faulty antennas on uplink data transmission does not vanish even with unlimited number of antennas. However, the signal detection performance can be improved with a priori knowledge on the indices of faulty antennas. This motivates us to propose the approach for simultaneous channel estimation and faulty antenna detection. By exploiting the fact that the degrees of freedom of the physical channel matrix are smaller than the number of free parameters, the channel estimation and faulty antenna detection can be formulated as an extended atomic norm denoising problem and solved efficiently via the alternating direction method of multipliers. Furthermore, we improve the computational efficiency by proposing a fast algorithm and show that it is a good approximation of the corresponding extended atomic norm minimization method. Numerical simulations are provided to compare the performances of the proposed algorithms with several existing approaches and demonstrate the performance gains of detecting the indices of faulty antennas.
Investigating the effects of using nanomaterials on moisture damage of HMA

In the past few years, several studies have been conducted focusing on the use of nanomaterials as additives in asphalt mixtures. Nevertheless, the effects of these additives on the moisture susceptibility of asphalt mixtures have not been studied. In this study, the effects of using nano-CaCO3 as an antistrip additive on moisture susceptibility of asphalt mixtures have been assessed using the surface free energy (SFE) method and modified Lottman test. Hot mix asphalt (HMA) samples were made with asphalt binders containing 0, 2, 4 and 6% of nano-CaCO3 and two sources of aggregate, namely limestone and granite. One, three and five freeze–thaw cycles were applied to HMA samples in a modified Lottman test to explore the effect of nanomaterials, clearly. The results of the modified Lottman test show that the wet/dry ratio values of indirect tensile strength (ITS) for mixtures containing nanomaterials were higher than those of control samples. In addition, the results of the SFE method indicate that nano-CaCO3 increases the wettability of the asphalt binder on the aggregate and promotes the adhesion between the asphalt binder and aggregate. Adding nanomaterials leads to the decrease of the acid component of SFE and increases the basic component of SFE of the asphalt binder that leads to an increase of adhesion between the asphalt binder and sensitive aggregate against moisture damage.
Behavioral and Cellular Level Changes in the Aging Somatosensory System

A study of the peripheral sensory system of young and aged Blk6 mice obtained from the National Institutes on Aging mouse colony is described. Behavioral assays showed male and female aged mice had decreased sensitivity to thermal stimuli. The receptor for the growth factor artemin (Artn), GFRα3, and the ion channel TRPV1, which is expressed by 95–99% of GFRα3‐positive primary sensory neurons, was also decreased. Calcium imaging of isolated dorsal root ganglia neurons grown with nerve growth factor was used to test the in vitro effects of Artn on TRPV1 activation by capsaicin in young and old neurons. Artn potentiated initial TRPV1 responses to capsaicin in young and old neurons, but the percent of capsaicin responders following repeated exposure to capsaicin increased only in young neurons. The lack of change in aged neurons suggests that differences in TRPV1 responses occur with aging in the somatosensory system.
Secure and privacy preserving average consensus

Due to the wide application of consensus algorithms, its privacy and security problems have attracted significant attention. In this paper, we consider the average consensus scheme threatened by a set of cooperating malicious and curious attackers, who intend to not only estimate the initial states of other benign agents but also disturb the consensus (perturb the final consensus value or prevent consensus) via injecting malicious signal to the consensus process. A privacy-preserving average consensus algorithm equipped with an attack detector is designed for each benign agent. We show that the privacy of initial states of all benign agents are guaranteed under mild conditions. To characterize the maximum disturbance the adversaries can introduce to the system, we calculate the reachable set of all possible system states under stealthy attacks, i.e., attacks the do not trigger an alarm. Numerical examples are given to validate the theoretical results.
Microvesicle Cargo and Function Changes upon Induction of Cellular Transformation*

Extracellular vesicles (EVs), including exosomes and microvesicles (MVs), have emerged as a major form of intercellular communication, playing important roles in several physiological processes and diseases, including cancer. EVs generated by cancer cells contain a variety of proteins and RNA species that can be transferred between cancer cells as well as between cancer and non-transformed (normal) cells, thereby impacting a number of aspects of cancer progression. Here we show how oncogenic transformation influences the biogenesis and function of EVs using a mouse embryonic fibroblast (MEF) cell line that can be induced to express an oncogenic form of diffuse B cell lymphoma (Dbl). Although MEFs induced to express onco-Dbl generated a similar amount of MVs as uninduced control cells, we found that MVs isolated from onco-Dbl-transformed cells contain a unique signaling protein, the ubiquitously expressed non-receptor tyrosine kinase focal adhesion kinase. The addition of MVs isolated from MEFs expressing onco-Dbl to cultures of fibroblasts strongly promoted their survival and induced their ability to grow under anchorage-independent conditions, outcomes that could be reversed by knocking down focal adhesion kinase and depleting it from the MVs or by inhibiting its kinase activity using a specific inhibitor. We then showed the same to be true for MVs isolated from aggressive MDAMB231 breast cancer cells. Together, these findings demonstrate that the induction of oncogenic transformation gives rise to MVs, which uniquely contain a signaling protein kinase that helps propagate the transformed phenotype and thus may offer a specific diagnostic marker of malignant disease.