Miracle-dz/UniFAR-FTUs huggingface dataset:
Antiviral Flavonoid‐Type C‐Glycosides from the Flowers of Trollius chinensis

Two new flavonoid‐type C‐glycosides, trollisin I (=(1S)‐1,5‐anhydro‐1‐[2‐(3,4‐dihydroxyphenyl)‐5‐hydroxy‐7‐methoxy‐4‐oxo‐4H‐[1]benzopyran‐8‐yl]‐2‐O‐(2‐methylbutanoyl)‐D‐glucitol; 1) and its 2‐O‐benzoyl congener trollisin II (2), were isolated from Trollius chinensis Bunge, together with the two known compounds 2″‐O‐(2′′′‐methylbutanoyl)isoswertisin (3) and vitexin galactoside (4). All compounds were identified by HR‐ESI‐MS and in‐depth NMR‐spectroscopic analyses. In antiviral assays, compound 3 was found to be moderately active towards influenza virus A.
Bicycle Helmet Size, Adjustment, and Stability

Objectives: One of the main requirements of a protective bicycle helmet is to provide and maintain adequate coverage to the head. A poorly fitting or fastened helmet may be displaced during normal use or even ejected during a crash. The aims of the current study were to identify factors that influence the size of helmet worn, identify factors that influence helmet position and adjustment, and examine the effects of helmet size worn and adjustment on helmet stability. Methods: Recreational and commuter cyclists in Sydney were surveyed to determine how helmet size and/or adjustment affected helmet stability in the real world. Anthropometric characteristics of the head were measured and, to assess helmet stability, a test analogous to the requirements of the Australian bicycle helmet standard was undertaken. Results: Two hundred sixty-seven cyclists were recruited across all age groups and 91% wore an AS/NZS 2063–compliant helmet. The main ethnic group was Europeans (71%) followed by Asians (18%). The circumferences of the cyclists’ heads matched well the circumference of the relevant ISO headform for the chosen helmet size, but the head shapes differed with respect to ISO headforms. Age and gender were associated with wearing an incorrectly sized helmet and helmet adjustment. Older males (>55 years) were most likely to wear an incorrectly sized helmet. Adult males in the 35–54 year age group were most likely to wear a correctly adjusted helmet. Using quasistatic helmet stability tests, it was found that the correctness of adjustment, rather than size, head dimensions, or shape, significantly affected helmet stability in all test directions. Conclusions: Bicycle helmets worn by recreational and commuter cyclists are often the wrong size and are often worn and adjusted incorrectly, especially in children and young people. Cyclists need to be encouraged to adjust their helmets correctly. Current headforms used in standards testing may not be representative of cyclists’ head shapes. This may create challenges to helmet suppliers if on one hand they optimize the helmet to meet tests on ISO-related headforms while on the other seeking to offer greater range of sizes.
Schizophrenia is not associated with the ERBB3 gene in a Han Chinese population sample: Results from case-control and family-based studies

ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3), encoding a receptor of neuregulin-1 (NRG1), has been considered a functional candidate gene for schizophrenia susceptibility. In order to investigate a relationship between ERBB3 gene and schizophrenia in the Chinese population, case-control and family-based studies were carried out in 470 cases matched by controls, and in 532 family trios. Our results failed to show any evidence of significant association between the ERBB3 rs2292238 polymorphism and schizophrenia.
Avatar realism and social interaction quality in virtual reality

In this paper, we describe an experimental method to investigate the effects of reduced social information and behavioral channels in immersive virtual environments with full-body avatar embodiment. We compared physical-based and verbal-based social interactions in real world (RW) and virtual reality (VR). Participants were represented by abstract avatars that did not display gaze, facial expressions or social cues from appearance. Our results show significant differences in terms of presence and physical performance. However, differences in effectiveness in the verbal task were not present. Participants appear to efficiently compensate for missing social and behavioral cues by shifting their attentions to other behavioral channels.
Integration of Vietnamese Refugees into the Norwegian Labor Market: The Impact of War Trauma 1

One hundred forty-five Vietnamese boat refugees were interviewed on arrival and after three years in Norway. The integration into the labor market was poor and the rate of unemployment was relatively high (16%). Eighty-two (63%) were members of the labor force, the rest being students (n=41) or housewives (n=6). Both loss of social status in Vietnam in 1975 and experiences of war trauma were independently related to labor force participation, when age, sex and mental health were controlled for. The risk of unemployment was increased among men and among refugees with low formal education and with no accompanying spouse. The results indicate that war trauma may have an impact on career choice and integration into the labor market which is independent of mental health. Future immigration policies should probably improve the refugees’ opportunities to establish intraethnic social networks to facilitate job finding and entrepreneurship.
Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.

BACKGROUND Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction. METHODS In a multicenter trial, we randomly assigned 204 patients with acute myocardial infarction to receive an intracoronary infusion of progenitor cells derived from bone marrow (BMC) or placebo medium into the infarct artery 3 to 7 days after successful reperfusion therapy. RESULTS At 4 months, the absolute improvement in the global left ventricular ejection fraction (LVEF) was significantly greater in the BMC group than in the placebo group (mean [+/-SD] increase, 5.5+/-7.3% vs. 3.0+/-6.5%; P=0.01). Patients with a baseline LVEF at or below the median value of 48.9% derived the most benefit (absolute improvement in LVEF, 5.0%; 95% confidence interval, 2.0 to 8.1). At 1 year, intracoronary infusion of BMC was associated with a reduction in the prespecified combined clinical end point of death, recurrence of myocardial infarction, and any revascularization procedure (P=0.01). CONCLUSIONS Intracoronary administration of BMC is associated with improved recovery of left ventricular contractile function in patients with acute myocardial infarction. Large-scale studies are warranted to examine the potential effects of progenitor-cell administration on morbidity and mortality.
Effort, co‐operation and co‐ordination in an open source software project: GNOME

Abstract This paper presents results from research into open source projects from a software engineering perspective. The research methodology employed relies on public data retrieved from the CVS repository of the GNOME project and relevant discussion groups. This methodology is described, and results concerning the special characteristics of open source software development are given. These data are used for a first approach to estimating the total effort to be expended.
A New EWMA Chart Based on Weighted Loss Function for Monitoring the Process Mean and Variance

With the weighted loss function, a new single Exponential Weighted Moving Average (EWMA) chart (WLE chart hereafter for short) is proposed to detect both mean and variance shifts simultaneously. It includes the EWMA control chart based on the semicircle statistic and weighted‐loss‐function control chart as special cases. Numerical studies show that the WLE chart is superior to the weighted‐loss‐function Cumulative Sum (CUSUM) chart when the mean and standard deviation shifts are both small, and offers at least comparable detection ability with the WLC chart in other cases. Compared with the Shiryaev–Roberts chart, the WLE chart has a better or comparable performance except for small and moderate mean shifts. Furthermore, an equivalent form of the WLE chart is developed to diagnose the source and direction of a process change. Copyright © 2014 John Wiley & Sons, Ltd.
Variational Analysis in Semi-Infinite and Infinite Programming, I: Stability of Linear Inequality Systems of Feasible Solutions

This paper concerns applications of advanced techniques of variational analysis and generalized differentiation to parametric problems of semi-infinite and infinite programming, where decision variables run over finite-dimensional and infinite-dimensional spaces, respectively. Part I is primarily devoted to the study of robust Lipschitzian stability of feasible solutions maps for such problems described by parameterized systems of infinitely many linear inequalities in Banach spaces of decision variables indexed by an arbitrary set $T$. The parameter space of admissible perturbations under consideration is formed by all bounded functions on $T$ equipped with the standard supremum norm. Unless the index set $T$ is finite, this space is intrinsically infinite-dimensional (nonreflexive and nonseparable) of the $l_\infty$ type. By using advanced tools of variational analysis and exploiting specific features of linear infinite systems, we establish complete characterizations of robust Lipschitzian stability entirely via their initial data with computing the exact bound of Lipschitzian moduli. A crucial part of our analysis addresses the precise computation of the coderivative of the feasible set mapping and its norm. The results obtained are new in both semi-infinite and infinite frameworks.
Better to Give and to Compete? Prosocial and Competitive Motives as Interactive Predictors of Citizenship Behavior

ABSTRACT Research has returned mixed results concerning the relationship between prosocial motivation and citizenship behavior. Building from research suggesting that mixed motives might explain these equivocal findings, we conducted two field studies examining the interaction between prosocial and competitive motives and two types of citizenship behavior. Prosocial motivation, but not competitive motivation, was positively related to citizenship behavior directed at others, though this relationship was weakened when prosocial motives were accompanied by competitive motives. Prosocial motives compensated for weak competitive motives to predict citizenship behavior directed toward the organization. Our studies expand research on prosocial and competitive motivation, mixed-motives, and citizenship behavior. Further, they carry personnel implications given that many organizations seek to hire employees high on both competitive and prosocial motivation.
Invited Talk: Fun with Software Developers and Biometrics

The use of low-cost, widely available, biometric sensors has skyrocketed over the past few years, enabling anyone to measure how their physiological signals change as they go about their daily lives. We use these sensors to understand software development activities, however, their use is not straightforward, nor is it easy. In this paper, we introduce some common sensors, along with some difficulties we encountered in using them in our experiments as well as how we worked past them. We call on everyone in our community to share best practices in sensor application and analysis in order to enable our field to grow as quickly as possible while producing robust, reliable results.
Monitoring Consumer Satisfaction With Inpatient Service Delivery: The Inpatient Evaluation of Service Questionnaire

Objective: To report on the development, testing and psychometric properties of a brief consumer satisfaction measure for use with psychiatric inpatients. Method: Focus group discussions with inpatients were used to develop a pool of items related to satisfaction with hospital stay. A second cohort of 72 inpatients was invited to rate the 51 items that emerged for importance in contributing to satisfaction. Mean importance scores highlighted 20 items that were subsequently framed into neutrally worded statements. A draft questionnaire comprising these statements was introduced, on a trial basis, in a range of inpatient facilities. Results: Factor analysis of 356 completed questionnaires yielded three factors comprising a staff-patient alliance; doctor/treatment issues; and an environmental component. Psychometric properties include good response variability and high internal consistency. Conclusions: The Inpatient Evaluation of Service Questionnaire addresses many of the shortcomings of existing satisfaction measures. It was developed through extensive consumer involvement, it is simply worded, easy to score and appears to perform well with acute and rehabilitation inpatients.
Immunopathology and Infectious Diseases Central Nervous System Fibrosis Is Associated with Fibrocyte-Like Infiltrates

Fibrotic wall formation is essential for limiting pathogen dissemination during brain abscess development. However, little is known about the regulation of fibrotic processes in the central nervous system (CNS). Most CNS injury responses are associated with hypertrophy of resident astrocytes, a process termed reactive gliosis. Studies of fibrosis outside the CNS have identified two bone marrow–derived cell types, fibrocytes and alternatively activated M2 macrophages, as key mediators of fibrosis. The current study used bone marrow chimeras generated from green fluorescent protein transgenic mice to evaluate the appearance of these cell types and whether bone marrow– derived cells were capable of acquiring fibrotic characteristics during brain abscess development. Immunofluorescence staining revealed partial overlap between green fluorescent protein, -smooth muscle actin, and procollagen, suggesting that a population of cells forming the brain abscess capsule originate from a bone marrow precursor. In addition, the influx of fibrocyte-like cells into brain abscesses immediately preceded the onset of fibrotic encapsulation. Fibrotic wall formation was also associated with increased numbers of alternatively activated M2 microglia and macrophages. To our knowledge, this is the first study demonstrating that bone marrow–derived infiltrates are capable of expressing fibrotic molecules during CNS inflammation. (Am J Pathol 2011, 179:2952–2962; DOI: 10.1016/j.ajpath.2011.08.036)
Metalloproteinase-mediated Regulation of L-selectin Levels on Leucocytes (*)

Leucocyte (L)-selectin can be proteolytically cleaved in the membrane proximal extracellular region to yield a soluble fragment that contains the functional lectin and epidermal growth factor domains. A variety of stimuli are known to stimulate L-selectin shedding including chemoattractants, phorbol esters, and L-selectin cross-linking; however, the enzymes that regulate L-selectin expression are not characterized. In this study we have used phorbol ester to stimulate endoproteolytic release of L-selectin and identified a major role for a cell surface metalloproteinase (L-selectin sheddase) in this process. The hydroxamic acid-based inhibitor of zinc-dependent matrix metalloproteinases Ro 31-9790 completely prevented shedding of cell surface L-selectin from leucocytes in mouse, rat, and man. L-selectin was susceptible to cleavage by known matrix metalloproteinases. Recombinant human fibroblast collagenase (MMP1) reduced the number of L-selectin-positive lymphocytes to a similar extent as phorbol ester activation, and stromelysin (MMP3) had a partial effect on L-selectin expression. Gelatinases A (MMP2) and B (MMP9) were without effect. Lymphocytes did not express fibroblast collagenase or stromelysin at the cell surface, and tissue inhibitor of metalloproteinases (TIMP) did not affect L-selectin levels. L-selectin sheddase was not detected in media harvested from phorbol ester-stimulated lymphocytes and was only able to cleave L-selectin in the cis but not the trans configuration. These results suggest that endoproteolytic release of L-selectin from the leucocyte surface is mediated by a metalloproteinase (L-selectin sheddase), which is distinguishable from known matrix metalloproteinases. Understanding the regulation of L-selectin sheddase will be critical for controlling leucocyte migration from the blood.
Emission-Line Properties of 3CR Radio Galaxies. III. Origins and Implications of the Velocity Fields

We present the results of an analysis of the large-scale velocity fields of the ionized gas associated with powerful radio galaxies. Long-slit spectra of 52 objects provide a sample of resolved velocities that span a wide range of redshifts and radio and emission-line luminosities. Line widths reaching 1000 km s-1 and resolved velocity fields with amplitudes of up 1500 km s-1 are found on scales from 10 to 100 kpc in the environments of radio galaxies at redshifts greater than 0.5. The global velocities and FWHM are of comparable amplitudes in the FR II sources, while the FR I sources have FWHM values that are larger than their resolved velocity fields. We find evidence for systematically larger line widths and velocity field amplitudes at z > 0.6. Several of the largest amplitude systems contain two galaxies with small projected separations. All of the greater than 1000 km s-1 systems occur in objects at z > 0.6 and all have comparable radio and [O II] sizes. There is a weak correlation of off-nuclear line widths and velocity field with the ratio of the radio and emission-line sizes, but it is of low statistical significance and there is a very large dispersion. The change in properties at redshifts above z ∼ 0.6 could reflect a difference in environments of the host galaxies, with the hosts inhabiting higher density regions with increasing redshift (e.g., Hill & Lilly). The mass of ionized gas and the apparent enclosed dynamical mass are correlated and both increase steeply with redshift and/or radio power. The origin of the velocities remains uncertain. The data do not require jet-gas interactions to explain the kinematics and superficially are slightly more consistent with gravitational origins for the bulk of the kinematics. If the line width reflects the underlying gravitational potential, the observed FWHM traces the velocity dispersion of the host galaxy or its surrounding group or cluster. The highest velocities seen then point to interesting environments for intermediate- and high-redshift radio galaxies. Turbulent interactions with the expanding radio source as the origin of the kinematics are certainly not ruled out. In the jet interaction scenario, the maximum velocities seen in the nebula can be used to constrain the density of the preshock gas to be roughly ne > 0.6 cm-3.
Structural Determinants of Conformationally Selective, Prion-binding Aptamers*[boxs]

We have recently described the isolation of 2′-fluoropyrimidine-substituted RNA aptamers that bind selectively to disease-associated β-sheet-rich forms of the prion protein, PrP, from a number of mammalian species. These aptamers inhibit the accumulation of protease-resistant forms of PrP in a prion-seeded, in vitro conversion assay. Here we identify the minimal portions of two of these aptamers that retain binding specificity. We determine their secondary structures by a combination of modeling and solution probing. Finally, we identify an internal site for biotinylation of a minimized, synthetic aptamer and use the resultant reagent in the detection of abnormal forms of PrP in vitro.
Clustering mixed numerical and low quality categorical data: significance metrics on a yeast example

We present the M-BILCOM algorithm for clustering mixed numerical and categorical data sets, in which the categorical attribute values (CAs) are not certain to be correct and have associated confidence values (CVs) from 0.0 to 1.0 to represent their certainty of correctness. M-BILCOM performs bi-level clustering of mixed data sets resembling a Bayesian process. We have applied M-BILCOM to yeast data sets in which the CAs were perturbed randomly and CVs were assigned indicating the confidence of correctness of the CAs. On such mixed data sets M-BILCOM outperforms other clustering algorithms, such as AutoClass. We have applied M-BILCOM to real numerical data sets from gene expression studies on yeast, incorporating CAs representing Gene Ontology annotations on the genes and CVs representing Gene Ontology Evidence Codes on the CAs. We apply novel significance metrics to the CAs in resulting clusters, to extract the most significant CAs based on their frequencies and their CVs in the cluster. For genomic data sets, we use the most significant CAs in a cluster to predict gene function.
Urbanism and Tolerance: A Test of Some Hypotheses Drawn from Wirth and Stouffer

Teaff, Joseph, M. Powell Lawton, Lucille Nahemow and Diane Carlson 1978 "Impact of age integration on the well-being of elderly tenants in public housing. " Journal of Gerontology 33:126-33. U.S. Bureau of the Census 1960 Census of Population and Housing. Washington, D.C.: U.S. Government Printing Office. 1962 Census of Governments. Washington, D.C.: U.S. Government Printing Office. 1963 Census of Business and Manufacturing. Washington, D.C.: U.S. Government Printing Office. 1970 Census of Population and Housing. Washington, D.C.: U.S. Government Printing Office. 1977a Census of Governments. Washington, D.C.: U.S. Government Printing Office. 1977b Census of Business and Manufacturing. Washington, D.C.: U.S. Government Printing Office. 1980 Census of Population and Housing. Washington, D.C.: U.S. Government Printing Office. Ward, Russell, Mark LaGory and Susan Sherman 1985 "Neighborhood and network age concentration: Does age homogeneity matter for older people? Social Psychological Quarterly, forthcoming.
Alveolar extracellular 20S proteasome in patients with acute respiratory distress syndrome.

RATIONALE Repair mechanisms resulting in alveolar protein degradation in acute respiratory distress syndrome (ARDS) are largely unknown. OBJECTIVES To test whether the 20S proteasome is present and functional in the alveolar space in patients with ARDS. METHODS Proteasome antigenic concentration in bronchoalveolar lavage (BAL) supernatants was measured by ELISA in patients with ARDS (n = 64), acute lung injury (ALI) (n = 8), sarcoidosis (n = 13), and in healthy subjects (n = 8). Cleavage of specific fluorogenic substrates (+/-epoxomicin), I(125) albumin degradation rate, and gel filtration were used to quantify and characterize proteasomal activity. The presence of proteasomes was confirmed independently by electron microscopic techniques. MEASUREMENTS AND MAIN RESULTS Proteasome concentrations in patients with ARDS were markedly increased (1,069 +/- 1,194 ng/ml) in comparison to healthy subjects (60.8 +/- 49.8; P < 0.001), ALI (154 +/- 43; P = 0.006), and sarcoidosis (97.6 +/- 42.2; P = 0.037). All fluorogenic substrates were hydrolyzed (Suc-LLVY-AMC, 3.6 +/- 8.8 pkat/mg; BZ-VGR-AMC, 1.8 +/- 3.1; Suc-LLE-AMC, 1 +/- 1.7) by BAL supernatants of patients with ARDS, with inhibition by epoxomicin (P = 0.0001), and the majority of proteolytic activity was detected in BAL supernatant. Maximum hydrolyzing activity occurred at 660 kD and 20S proteasome was seen microscopically after purification and being released by pneumocytes type II. Proteasomal activity and albumin degradation rate in patients with ARDS were approximately 17-fold lower than in healthy subjects. Proteasomal activity in normal BAL was inhibited by BAL aliquots from patients with ARDS but not by denatured BAL, and returned to normal by purification. CONCLUSIONS For the first time, we identified extracellular, biologically active 20S proteasome in the alveolar space of patients with ARDS in concentrations much higher than in normal subjects or in those with ALI.