Miracle-dz/UniFAR-FTUs huggingface dataset:
Generalizability of career orientations: A comparative study in Switzerland and Great Britain

This study examined the generalizability of types of career orientation. Exploratory latent class analyses were used to examine whether structurally the same career orientations can be found across a large sample of Swiss German (N=737), Swiss French (N=319), and British (N=1,002) employees. The finding showed that the generalizability of career orientations was not supported across the two countries and not even between the German- and French-speaking parts of Switzerland. At least four career orientations were found in all samples. Country-specific inspection of these four career orientations showed that they differed in terms of their combinations of specific components (boundaryless, protean, advancement, and time orientation). Mixtures of types of career orientations exist and make it difficult to identify fully the same type of career orientation across different cultural contexts. Explanations for differences in career orientation are discussed focusing on the cultural and economic context of Switzerland and Great Britain. Implications for organizational career management practices as well as theory of the career orientation concept are discussed.
Collaborative relationships and dialogic conversations: ideas for a relationally responsive practice.

The author presents a set of philosophical assumptions that provide a different language for thinking about and responding to the persistent questions: "How can our therapy practices have relevance for people's everyday lives in our fast changing world, what is this relevance, and who determines it? " "Why do some shapes of relationships and forms of talk engage while others alienate? Why do some invite possibilities and ways forward not imagined before and others imprison us? " The author then translates the assumptions to inform a therapist's philosophical stance: a way of being. Next, she discusses the distinguishing features of the stance and how it facilitates collaborative relationships and dialogic conversations that offer fertile means to creative ends for therapists and their clients.
Shame and guilt in neurosis.

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Antioxidant and Nutritional Activity Studies of Green Leafy Vegetables

An investigation was carried out with nine green leafy vegetables (GLV’s) with their popular varieties most commonly grown in India to determine their biochemical composition. Among leafy vegetables ascorbic acid was found maximum in Chenopod cultivar Bathua Local (60.6 mg/100 g fw.) followed by Pusa Bathua -1 (23.0 mg/100g fw.) and spinach cultivar PS-1 (51 mg/100 g fw.). Significantly high level of total carotenoids was recorded in amaranth cultivar Pusa Lal Chaulai (69.4 mg/100 g fw.) & Pusa Kiran (59.0 mg/100g fw.), however Basella cultivar Local Red and Local Green recorded low value of total carotenoids (10.2 mg/100 g). High value of CUPRAC was recorded in chenopod cultivar Bathua Local (32.7 μ moltrolax/g) and Pusa Bathua-1 (23.0 μ moltrolax/g), while FRAP was maximum in Swiss Chard Local (4.2 μ mol ascorbic acid/ g f.w). Poly phenols content of GLV’s ranged from 1134 μg gallic acid equivalent (GAE)/ g of amaranth cultivar Pusa LalChaulai to 154 μg GAE/ g in case of palak cultivar Pusa Bharati. On overall basis the antioxidant capacity of leafy vegetables were in order of amaranth > chenopod > spinach > palak > fenugreek > sarson sag.
Red Galaxy Growth and the Halo Occupation Distribution

We have traced the past 7 Gyr of red galaxy stellar mass growth within dark matter halos. We have determined the halo occupation distribution, which describes how galaxies reside within dark matter halos, using the observed luminosity function and clustering of 40,696 0.2 < z < 1.0 red galaxies in Boötes. Half of ≃1011.9 h−1 M☉ halos host a red central galaxy, and this fraction increases with increasing halo mass. We do not observe any evolution of the relationship between red galaxy stellar mass and host halo mass, although we expect both galaxy stellar masses and halo masses to evolve over cosmic time. We find that the stellar mass contained within the red population has doubled since z = 1, with the stellar mass within red satellite galaxies tripling over this redshift range. In cluster mass halos (>1014 h−1 M☉) most of the stellar mass resides within satellite galaxies and the intracluster light, with a minority of the stellar mass residing within central galaxies. The stellar masses of the most luminous red central galaxies are proportional to halo mass to the power of ≃0.35. We thus conclude that halo mergers do not always lead to rapid growth of central galaxies. While very massive halos often double in mass over the past 7 Gyr, the stellar masses of their central galaxies typically grow by only ≃30%.
Combination Treatment with Erlotinib and Pertuzumab against Human Tumor Xenografts Is Superior to Monotherapy

In many solid tumors, overexpression of human epidermal growth factor receptors (e.g., HER1/EGFR and HER2) correlates with poor prognosis. Erlotinib (Tarceva) is a potent HER1/EGFR tyrosine kinase inhibitor. Pertuzumab (Omnitarg), a novel HER2-specific, recombinant, humanized monoclonal antibody, prevents heterodimerization of HER2 with other HERs. Both mechanisms disrupt signaling pathways, resulting in tumor growth inhibition. We evaluated whether inhibition of both mechanisms is superior to monotherapy in tumor cell lines expressing different HER levels. Human non–small cell lung cancer (NSCLC) cells (Calu-3: HER1/EGFR 0+, HER2 3+; QG56: HER1/EGFR 2-3+, HER2 0+) and breast cancer cells (KPL-4: HER1/EGFR 2-3+, HER2 3+) were implanted into BALB/c nu/nu mice and severe combined immunodeficient beige mice, respectively. Tumor-bearing mice (n = 12 or 15 per group) were treated with vehicle (Captisol or buffer), erlotinib (orally, 50 mg/kg/d), pertuzumab (i.p. 6 mg/kg/wk with a 2-fold loading dose), or erlotinib and pertuzumab for 20 (QG56), 27 (KPL-4), or 49 (Calu-3) days. Drug monotherapy had antitumor activity in all models. Tumor volume treatment-to-control ratios (TCR) with erlotinib were 0.36 (Calu-3), 0.79 (QG56), and 0.51 (KPL-4). Pertuzumab TCR values were 0.42, 0.51, and 0.64 in Calu-3, QG56, and KPL-4 models, respectively. Combination treatment resulted in additive (QG56: TCR 0.39; KPL-4: TCR 0.38) or greater than additive (Calu-3: TCR 0.12) antitumor activity. Serum tumor markers for NSCLC (Cyfra 21.1) and breast cancer (soluble HER2) were markedly inhibited by combination treatment (80-97% in Calu-3 and QG56; 92% in KPL-4), correlating with decreased tumor volume. Overall, erlotinib and pertuzumab are active against various human xenograft models, independently of HER1/EGFR or HER2 expression. A combination of these HER-targeted agents resulted in additive or greater than additive antitumor activity.
A violência escolar no contexto de privação de liberdade

A violencia no contexto escolar e um fenomeno que apresenta um forte incremento, atraindo crescentemente a atencao dos pesquisadores da area. Entretanto, as escolas instaladas nas unidades de privacao de liberdade nao tem merecido o mesmo interesse, apesar de sua reconhecida importância no direcionamento dos seus alunos, especialmente quando sao adolescentes, para formas nao delituosas de viver. Este artigo focaliza a violencia dirigida ao professor por seus alunos adolescentes, em sala de aula, no contexto de unidades de privacao de liberdade. A pesquisa objetivou compreender a percepcao dos professores acerca do fenomeno, discutindo as especificidades das relacoes de ensino-aprendizagem, marcadas pelas caracteristicas de uma escola inserida no sistema socioeducativo. Para a obtencao dos dados, foi utilizado um questionario com questoes estruturadas e semiestruturadas, que permitiu constatar que, para os professores, as manifestacoes de violencia se dao, em grande parte, de formas sutis, e sao percebidas como capazes de afetar diretamente a atuacao dos mesmos em sala de aula.
Visual Psychophysics and Physiological Optics Cone Dystrophy With ‘ ‘ Supernormal ’ ’ Rod ERG : Psychophysical Testing Shows Comparable Rod and Cone Temporal Sensitivity Losses With No Gain in Rod Function

Citation: Stockman A, Henning GB, Michaelides M, et al. Cone dystrophy with ‘‘supernormal’’ rod ERG: psychophysical testing shows comparable rod and cone temporal sensitivity losses with no gain in rod function. Invest Ophthalmol Vis Sci. 2014;55:832–840. DOI:10.1167/iovs. 13-12919 PURPOSE. We report a psychophysical investigation of 5 observers with the retinal disorder ‘‘cone dystrophy with supernormal rod ERG,’’ caused by mutations in the gene KCNV2 that encodes a voltage-gated potassium channel found in rod and cone photoreceptors. We compared losses for rodand for cone-mediated vision to further investigate the disorder and to assess whether the supernormal ERG is associated with any visual benefit.
Pleasure, arousal, and dominance: Exploring affective determinants of recreation satisfaction

This study explored the application of affective indicators in understanding recreation satisfaction among hunters, using A. Mehrabian and J.A. Russell's (1974) pleasure, arousal and dominance (P‐A‐D) model. Factor analysis was performed to examine the dimensional structure of affective response to a recreation engagement. Regression models examined the relationship between affect and conventional measures of recreation satisfaction. The results showed that affect did not factor into a 3‐dimensional structure suggested by the P‐A‐D model. Rather, a 1‐dimensional structure emerged. Affect explained moderate amounts of variance in four measures of satisfaction. Measures of satisfaction were also regressed on separate P‐A‐D dimensions. The pleasure dimension was the most important predictor of overall satisfaction with a hunting trip and a summated satisfaction measure. The dominance dimension was most important for satisfaction with chance to bag game. The arousal dimension consistently was lowest in predic.
Accelerated Maturation in Prefabricated Flaps by Transforming Growth Factor‐&bgr;: An Experimental Study in the Rabbit

&NA; We evaluated whether application of transforming growth factor‐&bgr; (TGF‐&bgr;) during the first operation could shorten the interval required before creating a neovascularized flap in rabbits. Central ear vessels were transferred under the skin. After different time intervals, the flaps were raised as an island flap. In the group receiving TGF‐&bgr;, flap survival was 94% of initial length, whereas the control group reached 49% of initial length 3 days later. Five days later, flap survival was 98% in the TGF‐&bgr; group and the control group reached 78%. Histological examination revealed prominent angioneogenesis surrounding implanted vessels in the rabbits receiving TGF‐&bgr;. This suggests that TGF‐&bgr; may accelerate flap maturation. Iwasawa M. Accelerated maturation in prefabricated flaps by transforming growth factor‐&bgr;: an experimental study in the rabbit. Ann Plast Surg 1993;31:72‐75
How a supportive partner may increase relationship satisfaction

ABSTRACT The way in which satisfaction with a romantic relationship may be affected by how supportive a partner is and how constructively they deal with conflict in that relationship was examined in young adults. Both greater support and less conflict were found to be independently associated with relationship satisfaction, implying that both are necessary for a satisfactory relationship. While support did not mitigate the possible effects of conflict on satisfaction, it may lead to more constructive conflict which in turn may enhance satisfaction. Support seen as being available as well as support that was received were independently associated with relationship satisfaction. Of the different forms of available support measured, only support reflecting being cared for was independently associated with relationship satisfaction. These results suggest that encouraging couples to be emotionally supportive to each other may improve the effectiveness of relationship counselling as well as relationship enhancement and problem prevention programmes.
Fertilizer Use in the United States

FERTITTTZER practice in the United States is highly variable. The most intensive use is found on the narrow belt of sandy land which follows the Atlantic coast line from Massachusetts south to the Florida Peninsula. Truck crops, small fruits, early potatoes, sweet potatoes, and many other crops are here grown in an intensive way, quite generally with the aid of chemical rather than of animal fertilizers. Inland, we find very heavy use of fertilizers in the Atlantic cotton states, but a much smaller use in the cotton states lying farther west. Fertilizer use in the Corn Belt is increasing, in general its extension being coincident with the development of winter wheat production. West of the Mississippi, however, there is as yet too small a fertilizer use to be significant. Data are presented in the following table. For convenience, the total amount of fertilizer used is estimated
Microtexture inpainting through Gaussian conditional simulation

Image inpainting consists in filling missing regions of an image by inferring from the surrounding content. In the case of texture images, inpainting can be formulated in terms of conditional simulation of a stochastic texture model. Many texture synthesis methods thus have been adapted to texture inpainting, but these methods do not offer theoretical guarantees since the conditional sampling is in general only approximate. Here we show that in the case of Gaussian textures, inpainting can be addressed with perfect conditional simulation relying on kriging estimation. We thus obtain a microtexture inpainting algorithm that is able to fill holes of any shape and size in an efficient manner while respecting exactly a stochastic model.
Bilingualism and bilingual education and their relationship to citizenship from a comparative German-Australian perspective

In this paper, the acceptance of bilingualism and the role of bilingual education are studied in Australia and Germany. The differences between these countries with respect to immigration and multiculturalism/multilingualism policies allows the study of the underlying reasons with regard to the handling of bilingualism. While in Germany a contrast between teaching of migrant and minority languages and foreign languages is obvious, the development of LOTE in Australia overcomes this distinction but not the reluctance towards bilingual education. It is then asked what is the meaning of bilingualism with regard to citizenship, which is based on the concept of the nation state in both countries, though in Australia at least concepts of a multicultural state are discussed. The connections of bilingualism/bilingual education and citizenship are also considered with regard to both countries within the context of political developments.
Planning and control in stochastic domains with imperfect information

Partially observable Markov decision processes (POMDPs) can be used to model complex control problems that include both action outcome uncertainty and imperfect observability. A control problem within the POMDP framework is expressed as a dynamic optimization problem with a value function that combines costs or rewards from multiple steps. Although the POMDP framework is more expressive than other simpler frameworks, like Markov decision processes (MDP), its associated optimization methods are more demanding computationally and only very small problems can be solved exactly in practice. The thesis focuses on two possible approaches that can he used to solve larger problems: approximation methods and exploitation of additional problem structure. First, a number of new efficient approximation methods and improvements of existing algorithms are proposed. These include (1) the fast informed bound method based on approximate dynamic programming updates that lead to piecewise linear and convex value functions with a constant number of linear vectors, (2) a grid-based point interpolation method that supports variable grids, (3) an incremental version of the linear vector method that updates value function derivatives, as well as (4) various heuristics for selecting grid-points. The new and existing methods are experimentally tested and compared on a set of three infinite discounted horizon problems of different complexity. The experimental results show that methods that preserve the shape of the value function over updates, such as the newly designed incremental linear vector and fast informed bound methods, tend to outperform other methods on the control performance test. Second, the thesis presents a number of techniques for exploiting additional structure in the model of complex control problems. These are studied as applied to a medical therapy planning problem--the management of patients with chronic ischemic heart disease. The new extensions proposed include factored and hierarchically structured models that combine the advantages of the POMDP and MDP frameworks and cut down the size and complexity of the information state space.
Neural Stem Cells as a Novel Platform for Tumor-Specific Delivery of Therapeutic Antibodies

Background Recombinant monoclonal antibodies have emerged as important tools for cancer therapy. Despite the promise shown by antibody-based therapies, the large molecular size of antibodies limits their ability to efficiently penetrate solid tumors and precludes efficient crossing of the blood-brain-barrier into the central nervous system (CNS). Consequently, poorly vascularized solid tumors and CNS metastases cannot be effectively treated by intravenously-injected antibodies. The inherent tumor-tropic properties of human neural stem cells (NSCs) can potentially be harnessed to overcome these obstacles and significantly improve cancer immunotherapy. Intravenously-delivered NSCs preferentially migrate to primary and metastatic tumor sites within and outside the CNS. Therefore, we hypothesized that NSCs could serve as an ideal cellular delivery platform for targeting antibodies to malignant tumors. Methods and Findings As proof-of-concept, we selected Herceptin™ (trastuzumab), a monoclonal antibody widely used to treat HER2-overexpressing breast cancer. HER2 overexpression in breast cancer is highly correlated with CNS metastases, which are inaccessible to trastuzumab therapy. Therefore, NSC-mediated delivery of trastuzumab may improve its therapeutic efficacy. Here we report, for the first time, that human NSCs can be genetically modified to secrete anti-HER2 immunoglobulin molecules. These NSC-secreted antibodies assemble properly, possess tumor cell-binding affinity and specificity, and can effectively inhibit the proliferation of HER2-overexpressing breast cancer cells in vitro. We also demonstrate that immunoglobulin-secreting NSCs exhibit preferential tropism to tumor cells in vivo, and can deliver antibodies to human breast cancer xenografts in mice. Conclusions Taken together, these results suggest that NSCs modified to secrete HER2-targeting antibodies constitute a promising novel platform for targeted cancer immunotherapy. Specifically, this NSC-mediated antibody delivery system has the potential to significantly improve clinical outcome for patients with HER2-overexpressing breast cancer.
Neuromuscular Consequences of an Extreme Mountain Ultra-Marathon

We investigated the physiological consequences of one of the most extreme exercises realized by humans in race conditions: a 166-km mountain ultra-marathon (MUM) with 9500 m of positive and negative elevation change. For this purpose, (i) the fatigue induced by the MUM and (ii) the recovery processes over two weeks were assessed. Evaluation of neuromuscular function (NMF) and blood markers of muscle damage and inflammation were performed before and immediately following (n = 22), and 2, 5, 9 and 16 days after the MUM (n = 11) in experienced ultra-marathon runners. Large maximal voluntary contraction decreases occurred after MUM (−35% [95% CI: −28 to −42%] and −39% [95% CI: −32 to −46%] for KE and PF, respectively), with alteration of maximal voluntary activation, mainly for KE (−19% [95% CI: −7 to −32%]). Significant modifications in markers of muscle damage and inflammation were observed after the MUM as suggested by the large changes in creatine kinase (from 144±94 to 13,633±12,626 UI L−1), myoglobin (from 32±22 to 1,432±1,209 µg L−1), and C-Reactive Protein (from <2.0 to 37.7±26.5 mg L−1). Moderate to large reductions in maximal compound muscle action potential amplitude, high-frequency doublet force, and low frequency fatigue (index of excitation-contraction coupling alteration) were also observed for both muscle groups. Sixteen days after MUM, NMF had returned to initial values, with most of the recovery process occurring within 9 days of the race. These findings suggest that the large alterations in NMF after an ultra-marathon race are multi-factorial, including failure of excitation-contraction coupling, which has never been described after prolonged running. It is also concluded that as early as two weeks after such an extreme running exercise, maximal force capacities have returned to baseline.
Educational Advising for Student Retention: An Institutional Perspective

The quality of educational advisement may be as basic to the achievement of student and college goals as is the quality of teaching. Noel argues that educational advising is teaching and that advising should enhance the rational processes of thinking, reasoning, and deciding. ' There are arguments for conducting educational advising at the highest level; however, the most compelling reasons for competent educational advisement is its relation to institutional holding power. What conclusions may be drawn from available literature and research reports regarding the relationship between educational advising and student retention?
The Effect of Scoring Criteria Specificity on Peer and Self-assessment

The value of peer and self-assessments is commonly diminished by scoring range restriction by the raters. This investigation studied the effect of different levels of scoring criteria specificity and written feedback requests on the distribution of scores, the correlation between peer and self-assessments and the quantity and nature of written feedback. Increasing the number of criteria decreased the mean scores and increased the standard deviations of the peer and self-assessments, providing a wider range of scores and increasing the sensitivity of the instrument. Correlation between peer and self-assessment was improved with more specific criteria, depending on the statistic used. However, analysis revealed that the more specific written feedback requests elicited more peer feedback. Educators should consider the effects of criteria specificity and written feedback solicitation on rater behaviour when designing these instruments.