Miracle-dz/UniFAR-FTUs huggingface dataset:
Obesity prevalence and associated risk factors in outdoor living domestic horses and ponies

Reasons for performing study. The prevalence of obesity in companion animals, including horses and ponies has risen drastically in recent years and risk factors have been little investigated. Horses are unique amongst companion animals in that many are outdoor-living and forage independently on pasture; they also have a dual utility and companionship role. The body condition of wild and free-living equines is known to vary seasonally, yet previous estimates of the prevalence of obesity and associated risk factors in domestic animals do not consider this. Most previous studies were conducted during the summer months when pasture quality is greater and obesity prevalence is likely to be highest. In addition, many previous estimates do not use validated body condition scoring methods and rely on owner reporting. Objectives. To examine the prevalence and risk factors predictive of equine obesity at both the end of winter and the end of summer, in a domestic population of leisure horses with daily access to pasture. Using validated body condition scoring methods and a single, trained observer. Methods. Body condition and belly girth measurements were taken at the end of winter and during the summer in a population of leisure horses (n = 96) with outdoor pasture access for ≥6 h per day. Risk factor information was obtained by two owner questionnaires and analysed statistically using a mixed effects logistic regression model. The dependent variable was obese (BCS ≥ 7/9) or non-obese (BCS < 7/9). Risk factors associated with seasonal change in belly girth were also explored using a mixed effects linear regression model. Results. Obesity prevalence rose significantly from 27.08% at the end of winter to 35.41% during summer (p < 0.001). Breed was the risk factor most strongly associated with obesity (p < 0.001). Supplementary feed was not a strong predictor and there was no association with low intensity structured exercise. As winter BCS increased, the percentage seasonal change in belly girth decreased. Conclusions. Obesity prevalence differed between winter and summer in domestic equines. Supplementary feed and low intensity structured exercise in equines living outdoors for ≥6 h per day had limited or no effect on obesity levels. Seasonal variation in body condition was lower in obese equines. Potential relevance. It is important to consider season when studying equine obesity and obesity-associated disorders. Risk factor analysis suggests preventative measures may need to be breed specific. The metabolic implications of a lessened seasonal change in body condition in obese animals, warrants investigation.
Medical yoga: Another way of being in the world—A phenomenological study from the perspective of persons suffering from stress-related symptoms

The prevalence of stress-related illness has grown in recent years. Many of these patients seek help in primary health care. Yoga can reduce stress and thus complements pharmacological therapy in medical practice. To our knowledge, no studies have investigated patients’ experiences of yoga treatment in a primary health care setting or, specifically, the experiences of yoga when suffering from stress-related illness. Thus, the aim of the present study was to explore the meaning of participating in medical yoga as a complementary treatment for stress-related symptoms and diagnosis in a primary health care setting. This study has a descriptive phenomenological design and took place at a primary health care centre in Sweden during 2011. Five women and one man (43–51 years) participated. They were recruited from the intervention group (n=18) in a randomized control trial, in which they had participated in a medical yoga group in addition to standard care for 12 weeks. Data were collected by means of qualitative interviews, and a phenomenological data analysis was conducted. The essential meaning of the medical yoga experience was that the medical yoga was not an endpoint of recovery but the start of a process towards an increased sense of wholeness. It was described as a way of alleviating suffering, and it provided the participants with a tool for dealing with their stress and current situation on a practical level. It led to greater self-awareness and self-esteem, which in turn had an implicit impact on their lifeworld. In phenomenological terms, this can be summarized as Another way of being in the world, encompassing a perception of deepened identity. From a philosophical perspective, due to using the body in a new way (yoga), the participants had learnt to see things differently, which enriched and recast their perception of themselves and their lives.
Stem and Root Nodulation in Aeschynomene spp

Nodulation ability of 15 Rhizobium strains isolated from root and stem nodules of tropical Aeschynomene species was studied on 20 different Aeschynomene species and four other legumes—Arachis hypogaea, Stylosanthes guianensis, Macroptilium atropurpureum, and Sesbania rostrata. The results of this investigation showed that Aeschynomene species could be divided into three groups according to the cross-inoculation group concept.
Focus on Technique: Two-Stage Implant-Based Breast Reconstruction

Background: Acellular dermal matrix has become a frequent adjunct to traditional expander-based breast reconstruction. Its putative advantages include improved positioning of the prosthesis, better definition of the inframammary fold, amelioration of potential contracture, and overall enhancement of cosmesis. Concomitantly, there may be an increased risk of seroma, infection, and reconstructive failure. Methods: A thorough review of the techniques and outcomes of two-stage acellular dermis–assisted breast reconstruction was performed. Results: Key technical aspects of two-stage acellular dermal matrix–based reconstruction are presented. Indications, techniques of handling and inset, and select strategies to avoid and manage common complications are discussed. Evidence-based outcomes are reviewed. Conclusions: Acellular dermal matrix–based two-stage reconstruction continues to evolve as a viable option in breast reconstruction. Future studies will better delineate the risks and benefits of the technique.
Role of MicroRNA 126 in screening, diagnosis, and prognosis of diabetic patients in Egypt

MicroRNAs (miRNAs), family of non‐coding small RNAs, play a vital role in the regulation of blood glucose level. We aimed to investigate the relation of serum miRNA‐126 expression with impaired glucose tolerance as well as type 2 diabetes mellitus (T2DM) patients with and without complications. One hundred healthy controls, eighty‐six patients with IGT, and one hundred patients with T2DM were recruited in this study. Serum miRNA‐126 expression was assessed by quantitative real‐time polymerase chain reaction. We found a significant decrease of serum miRNA‐126 expression between IGT patients as well as diabetic patients when both compared with controls and between diabetic patients compared to IGT patients. A significant decrease of serum miRNA‐126 expression was detected in diabetic patients with complications compared to those without evident complications especially those with diabetic macrovascular complications and diabetic retinopathy. Serum microRNA‐126 expression could be a good marker for diagnosis of IGT and T2DM as well as for monitoring the outcomes of such disease. © 2016 IUBMB Life, 68(6):452–458, 2016
Curing schizophrenia by program rewriting in Esterel

Synchronous languages such as Esterel can execute a series of statements in a single "instant" of time. If this series spans a loop iteration then it is possible that a computation local to the loop will have several distinct results during that "instant", which is referred to as schizophrenia. This makes the compilation of synchronous languages into more traditional computation models (such as C code or sequential logic) difficult. In a previous work (2004), we suggested to deal with schizophrenia through preprocessing in the Esterel language extended with a non-instantaneous jump statement. We now advocate for and experimented with such a program transformation, establishing the correctness, the completeness and the efficiency of our approach.
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer.

BACKGROUND Fluoropyrimidine-based chemotherapy plus the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab is standard first-line treatment for metastatic colorectal cancer. We studied the effect of adding the anti-epidermal growth factor receptor (EGFR) antibody cetuximab to a combination of capecitabine, oxaliplatin, and bevacizumab for metastatic colorectal cancer. METHODS We randomly assigned 755 patients with previously untreated metastatic colorectal cancer to capecitabine, oxaliplatin, and bevacizumab (CB regimen, 378 patients) or the same regimen plus weekly cetuximab (CBC regimen, 377 patients). The primary end point was progression-free survival. The mutation status of the KRAS gene was evaluated as a predictor of outcome. RESULTS The median progression-free survival was 10.7 months in the CB group and 9.4 in the CBC group (P=0.01). Quality-of-life scores were lower in the CBC group. The overall survival and response rates did not differ significantly in the two groups. Treated patients in the CBC group had more grade 3 or 4 adverse events, which were attributed to cetuximab-related adverse cutaneous effects. Patients treated with cetuximab who had tumors bearing a mutated KRAS gene had significantly decreased progression-free survival as compared with cetuximab-treated patients with wild-type-KRAS tumors or patients with mutated-KRAS tumors in the CB group. CONCLUSIONS The addition of cetuximab to capecitabine, oxaliplatin, and bevacizumab resulted in significantly shorter progression-free survival and inferior quality of life. Mutation status of the KRAS gene was a predictor of outcome in the cetuximab group. (ClinicalTrials.gov number, NCT00208546.)
Spaces, Trees, and Colors

Document retrieval is one of the best-established information retrieval activities since the ’60s, pervading all search engines. Its aim is to obtain, from a collection of text documents, those most relevant to a pattern query. Current technology is mostly oriented to “natural language” text collections, where inverted indexes are the preferred solution. As successful as this paradigm has been, it fails to properly handle various East Asian languages and other scenarios where the “natural language” assumptions do not hold. Inthis survey, we cover the recent research in extending the document retrieval techniques to a broader class of sequence collections, which has applications in bioinformatics, data and web mining, chemoinformatics, software engineering, multimedia information retrieval, and many other fields. We focus on the algorithmic aspects of the techniques, uncovering a rich world of relations between document retrieval challenges and fundamental problems on trees, strings, range queries, discrete geometry, and other areas.
Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line

Functional interactions between catecholamines and cannabinoid transmission systems could explain the influence of Δ9‐tetrahydrocannabinol on several central activities. Hence, the presence of cannabinoid CB1 receptors in tyrosine hydroxylase (TH) containing cells has been suggested, providing clue for a direct control of catecholamines synthesis. In the present study, we evidenced the constitutive expression of functional cannabinoid CB1 receptors in N1E‐115 neuroblastoma and reported on the use of this model to examine the influence of diverse cannabinoid ligands on TH expression. Exposure of the cells to the high‐affinity agonist HU 210 (5 h) resulted in a significant decrease in TH content (pEC50: 6.40). In contrast, no change was observed after a similar treatment with the structurally unrelated agonist CP 55,940. Besides, the use of a luciferase reporter assay revealed that these two agonists showed opposite influences on TH gene promoter activity. Thus, in cells expressing pTH‐luc constructs, inhibition and induction of luciferase activity were respectively observed with HU 210 (pEC50: 8.95) and CP 55,940 (pEC50: 9.09). Pharmacological characterisation revealed that these reciprocal responses were both related to the specific activation of cannabinoid CB1 receptor, suggesting an agonist‐dependent modulation of distinct signalling pathways. While these data points out the possible pharmacological manipulation of TH expression by cannabinoid ligands, such approach should take into account the existence of agonist selective trafficking of cannabinoid CB1 receptor signalling.
Depletion of B‐Cells With Rituximab Improves Endothelial Function and Reduces Inflammation Among Individuals With Rheumatoid Arthritis

Background Individuals with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease, partly due to systemic inflammation and endothelial dysfunction. B‐cells play an important pathogenic role in the inflammatory process that drives RA disease activity. Rituximab, a chimeric murine/human monoclonal antibody that depletes B‐cells, is an effective therapy for RA. The purpose of this study was to determine whether B‐cell depletion with rituximab reduces systemic inflammation and improves macrovascular (brachial artery flow‐mediated dilation, FMD) and microvascular (reactive hyperemia) endothelial function in RA patients. Methods and Results RA patients received a single course of rituximab (1000 mg IV infusion at baseline and on day 15). FMD, reactive hyperemia, inflammatory markers, and clinical assessments were performed at baseline, week 12, and week 24. Twenty patients (95% female, median age 54 years) completed the study. Following treatment, FMD improved from a baseline of 4.5±0.4% to 6.4±0.6% at 12 weeks (mean±SE; P<0.0001), followed by a decline at week 24; a similar pattern was observed for hyperemic velocity. Significant decreases in RA disease scores, high‐sensitivity C‐reactive protein, erythrocyte sedimentation rate, and circulating CD19+ B‐cells were sustained through week 24. Cholesterol and triglycerides became significantly although modestly elevated during the study. Conclusions Depletion of B‐cells with rituximab improved macrovascular and microvascular endothelial function and reduced systemic inflammation, despite modest elevation in lipids. Given these results, rituximab should be evaluated in the future for its possible role in reducing excess cardiovascular risk in RA. Clinical Trial Registration URL http://ClinicalTrials.gov. Unique identifier: NCT00844714.
Note: This Copy Is for Your Personal, Non-commercial Use Only. to Order Presentation-ready Copies for Distribution to Your Colleagues or Clients, Contact Us at Www.rsna.org/rsnarights. Improving Communication of Diagnostic Radiology Findings through Structured Reporting 1 Materials and Methods

Purpose: To compare the content, clarity, and clinical usefulness of conventional (ie, free-form) and structured radiology reports of body computed tomographic (CT) scans, as evaluated by referring physicians, attending radiologists, and radiology fellows at a tertiary care cancer center. The institutional review board approved the study as a quality improvement initiative; no written consent was required. Three radiologists, three radiology fellows, three surgeons, and two medical oncologists evaluated 330 randomly selected conventional and structured radiology reports of body CT scans. For nonradiologists, reports were randomly selected from patients with diagnoses relevant to the physician's area of specialization. Each physician read 15 reports in each format and rated both the content and clarity of each report from 1 (very dissatisfi ed or very confusing) to 10 (very satisfi ed or very clear). By using a previously published radiology report grading scale, physicians graded each report's effectiveness in advancing the patient's position on the clinical spectrum. Mixed-effects models were used to test differences between report types.
Current Perspectives on Therapy Dog Welfare in Animal-Assisted Interventions

Simple Summary In animal-assisted interventions (AAIs) animals are used as adjuncts to therapy to positively affect human health. The practice of implementing dogs into therapeutic environments is emerging and as a result, there has been a growing scientific interest on human health outcomes over the past decades. Research efforts into the canine perspective of AAIs have been scarce. Accordingly, there is little consensus on the impact of such interventions on the animals involved. This paper aimed to contribute to the limited body of knowledge by reviewing available studies on therapy dogs’ welfare during AAIs. Moreover, discussion of theoretical and methodological issues, implications for practice and suggestions for future research are provided. Abstract Research into the effects of animal-assisted interventions (AAIs) has primarily addressed human health outcomes. In contrast, only few publications deal with the therapy dog experience of AAIs. This paper provides an overview on potential welfare threats that therapy dogs may encounter and presents the results of a review of available studies on welfare indicators for therapy dogs during AAIs. Previous investigations used physiological and behavioral welfare indicators and dog handler surveys to identify work-related stress. Research outcomes are discussed in the light of strengths and weaknesses of the methods used. Study results suggest that frequency and duration of AAI sessions, novelty of the environment, controllability, age and familiarity of recipients modulate animal welfare indicators. However, this review reveals that currently, clear conclusions on how the well-being of dogs is influenced by the performance in AAIs are lacking due to the heterogeneity of programs, recipient and session characteristics, small dog sample sizes and methodological limitations. This paper further aimed to identify unresolved difficulties in previous research to pave the way for future investigations supporting the applicability of scientific findings in practice.
Preserving Distances in Very Faulty Graphs

Preservers and additive spanners are sparse (hence cheap to store) subgraphs that preserve the distances between given pairs of nodes exactly or with some small additive error, respectively. Since real-world networks are prone to failures, it makes sense to study fault-tolerant versions of the above structures. This turns out to be a surprisingly difficult task. For every small but arbitrary set of edge or vertex failures, the preservers and spanners need to contain replacement paths around the faulted set. Unfortunately, the complexity of the interaction between replacement paths blows up significantly, even from 1 to 2 faults, and the structure of optimal preservers and spanners is poorly understood. In particular, no nontrivial bounds for preservers and additive spanners are known when the number of faults is bigger than 2. Even the answer to the following innocent question is completely unknown: what is the worst-case size of a preserver for a single pair of nodes in the presence of f edge faults? There are no super-linear lower bounds, nor subquadratic upper bounds for f>2. In this paper we make substantial progress on this and other fundamental questions: - We present the first truly sub-quadratic size fault-tolerant single-pair preserver in unweighted (possibly directed) graphs: for any n node graph and any fixed number f of faults, O~(fn^{2-1/2^f}) size suffices. Our result also generalizes to the single-source (all targets) case, and can be used to build new fault-tolerant additive spanners (for all pairs). - The size of the above single-pair preserver grows to O(n^2) for increasing f. We show that this is necessary even in undirected unweighted graphs, and even if you allow for a small additive error: If you aim at size O(n^{2-eps}) for \eps>0, then the additive error has to be \Omega(eps f). This surprisingly matches known upper bounds in the literature. - For weighted graphs, we provide matching upper and lower bounds for the single pair case. Namely, the size of the preserver is Theta(n^2) for f > 1 in both directed and undirected graphs, while for f=1 the size is Theta(n) in undirected graphs. For directed graphs, we have a superlinear upper bound and a matching lower bound. Most of our lower bounds extend to the distance oracle setting, where rather than a subgraph we ask for any compact data structure.
How to Compute under AC 0 Leakage without Secure Hardware

We study the problem of computing securely in the presence of leakage on the computation’s internals. Our main result is a general compiler that compiles any algorithm P , viewed as a boolean circuit, into a functionally equivalent algorithm P (cid:2) . The compiled P (cid:2) can then be run repeatedly on adversarially chosen inputs in the presence of leakage on its internals: In each execution of P (cid:2) , an AC 0 adversary can (adaptively) choose any leakage function that can be computed in AC 0 and has bounded output length, apply it to the values on P (cid:2) ’s internal wires in that execution, and view its output. We show that no such leakage adversary can learn more than P ’s input-output behavior. In particular, the internals of P are protected. Security does not rely on any secure hardware, and is proved under a computational intractability assumption regarding the hardness of computing inner products for AC 0 circuits with pre-processing. This new assumption has connections to long-standing open problems in complexity theory.
Chemical Composition and in Vitro Evaluation of the Antioxidant and Antimicrobial Activities of Eucalyptus gillii Essential Oil and Extracts

In this study, essential oil and various extracts (hexane, petroleum ether, acetone, ethanol, methanol and water) of Eucalyptus gilii were screened for their chemical composition, antimicrobial and antioxidant activities. The essential oil chemical composition was analyzed by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detection (GC-FID), respectively. Thirty four compounds were identified, corresponding to 99.5% of the total essential oil. Tannins [104.9–251.3 g catechin equivalent (CE)/Kg dry mass], flavonoids [3.3–34.3 g quercetin equivalent (QE)/Kg dry mass], phenolics [4.7–216.6 g gallic acid equivalent (GAE)/Kg dry mass] and anthocyannins [1.2–45.3 mg cyanidin-3-glucoside equivalent (C3GE)/Kg dry mass] of various extracts were investigated. Free radical scavenging capacity of all samples was determinedt. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, the IC50 of essential oil was 163.5 ± 10.7 mg/L and in the 2,2'-azinobis-3-ethylbenzothiazoline-6-sulphonate (ABTS) assay, it was 94.7 ± 7.1 mg/L. Among the various extracts, the water extract showed the best result (IC50 = 11.4 ± 0.6 mg/L) in the DPPH assay which was comparable to vitamin C (IC50 = 4.4 ± 0.2 mg/L). The antimicrobial activities were evaluated against different bacterial and fungal strains. Gram positive bacteria were found to be more sensitive to the essential oil and extracts than Gram negative ones. Anthocyanins seem to have a major effect on the growth of Bacillus subtilis (R2 = 0.79). A significant antifungal activity was observed against the yeast and fungi. Correlations between chemical composition and antioxidant activities were studied and R2 values were about 0.96 for the effect of phenolics on the DPPH assay.