Miracle-dz/UniFAR-FTUs huggingface dataset:
Astrocytic Deformity and Globular Structures Are Characteristic of the Brains of Patients with Aceruloplasminemia

Aceruloplasminemia is an interesting disease, the study of which helps elucidate how iron-induced oxidative stress is involved in neuronal cell death. In order to study the neuropathological characteristics associated with oxidative stress, we scrutinized the brains of 5 patients with aceruloplasminemia histopathologically and immunohistochemically. The pathological findings were essentially similar in all patients. In the frontal cortices, iron deposition and neuronal cell loss were trivial, but in the basal ganglia (especially in the caudate nucleus and putamen), severe iron overload and extensive neuronal loss were noted. Iron deposition was more prominent in the astrocytes than in the neurons in both regions. 4-hydroxynonenal (HNE), one of the most physiologically active lipid peroxides, was strongly detected on neurons and astrocytes by immunostaining. Markedly deformed astrocytes were observed in the striatum. These astrocytes were similar to Alzheimer type 1 astrocytes. Globular structures were seen in proportion to the degree of iron deposition. They clearly reacted with anti-glial fibrillary acidic protein (GFAP) and anti-S-100 antibodies and contained glial fibril-like filaments, but showed no or only faint immunoreactivity to antibodies for neuronal marker proteins, such as neurofilament and synaptophysin. Therefore, the globular structures presumably originated from astrocytes. The structures also reacted positively to anti-HNE and anti-ubiquitin antibodies. We conclude that astrocytic deformities and globular structures are characteristic neuropathological features of aceruloplasminemia and are closely linked to iron overload and subsequent oxidative stress.
Physiological Characterization of Vestibular Efferent Brainstem Neurons Using a Transgenic Mouse Model

The functional role of efferent innervation of the vestibular end-organs in the inner ear remains elusive. This study provides the first physiological characterization of the cholinergic vestibular efferent (VE) neurons in the brainstem by utilizing a transgenic mouse model, expressing eGFP under a choline-acetyltransferase (ChAT)-locus spanning promoter in combination with targeted patch clamp recordings. The intrinsic electrical properties of the eGFP-positive VE neurons were compared to the properties of the lateral olivocochlear (LOC) brainstem neurons, which gives rise to efferent innervation of the cochlea. Both VE and the LOC neurons were marked by their negative resting membrane potential <−75 mV and their passive responses in the hyperpolarizing range. In contrast, the response properties of VE and LOC neurons differed significantly in the depolarizing range. When injected with positive currents, VE neurons fired action potentials faithfully to the onset of depolarization followed by sparse firing with long inter-spike intervals. This response gave rise to a low response gain. The LOC neurons, conversely, responded with a characteristic delayed tonic firing upon depolarizing stimuli, giving rise to higher response gain than the VE neurons. Depolarization triggered large TEA insensitive outward currents with fast inactivation kinetics, indicating A-type potassium currents, in both the inner ear-projecting neuronal types. Immunohistochemistry confirmed expression of Kv4.3 and 4.2 ion channel subunits in both the VE and LOC neurons. The difference in spiking responses to depolarization is related to a two-fold impact of these transient outward currents on somatic integration in the LOC neurons compared to in VE neurons. It is speculated that the physiological properties of the VE neurons might be compatible with a wide-spread control over motion and gravity sensation in the inner ear, providing likewise feed-back amplification of abrupt and strong phasic signals from the semi-circular canals and of tonic signals from the gravito-sensitive macular organs.
Overlapping Probabilities of Top Ranking Gene Lists, Hypergeometric Distribution, and Stringency of Gene Selection Criterion

When the same set of genes appear in two top ranking gene lists in two different studies, it is often of interest to estimate the probability for this being a chance event. This overlapping probability is well known to follow the hypergeometric distribution. Usually, the lengths of top-ranking gene lists are assumed to be fixed, by using a pre-set criterion on, e.g., p-value for the t-test. We investigate how overlapping probability changes with the gene selection criterion, or simply, with the length of the top-ranking gene lists. It is concluded that overlapping probability is indeed a function of the gene list length, and its statistical significance should be quoted in the context of gene selection criterion
Ubiquitin Carboxy-Terminal Hydrolase-L1 as a Serum Neurotrauma Biomarker for Exposure to Occupational Low-Level Blast

Repeated exposure to low-level blast is a characteristic of a few select occupations and there is concern that such occupational exposures present risk for traumatic brain injury. These occupations include specialized military and law enforcement units that employ controlled detonation of explosive charges for the purpose of tactical entry into secured structures. The concern for negative effects from blast exposure is based on rates of operator self-reported headache, sleep disturbance, working memory impairment, and other concussion-like symptoms. A challenge in research on this topic has been the need for improved assessment tools to empirically evaluate the risk associated with repeated exposure to blast overpressure levels commonly considered to be too low in magnitude to cause acute injury. Evaluation of serum-based neurotrauma biomarkers provides an objective measure that is logistically feasible for use in field training environments. Among candidate biomarkers, ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) has some empirical support and was evaluated in this study. We used daily blood draws to examine acute change in UCH-L1 among 108 healthy military personnel who were exposed to repeated low-level blast across a 2-week period. These research volunteers also wore pressure sensors to record blast exposures, wrist actigraphs to monitor sleep patterns, and completed daily behavioral assessments of symptomology, postural stability, and neurocognitive function. UCH-L1 levels were elevated as a function of participating in the 2-week training with explosives, but the correlation of UCH-L1 elevation and blast magnitude was weak and inconsistent. Also, UCH-L1 elevations did not correlate with deficits in behavioral measures. These results provide some support for including UCH-L1 as a measure of central nervous system effects from exposure to low-level blast. However, the weak relation observed suggests that additional indicators of blast effect are needed.
Diversity in Resource Consumption Patterns and Robustness of Costing Systems to Errors

Practitioners and academics hypothesize that when there is high diversity in resource consumption patterns, costing systems are more sensitive to errors. Given that firms' resources to enhance costing accuracy are typically constrained, it is argued that costing system refinement efforts should be focused on such cases, where they are likely to be most effective. However, little guidance is available on how to identify those situations where costing system refinement efforts (such as introducing an activity-based costing system) are likely to pay off most in terms of increased accuracy. Further, to our knowledge, the existing guidance provided by this high diversity rule of thumb has never been empirically tested. Using a simulation method, we address these issues in this paper. Specifically, we model various aspects, and degrees, of diversity in the resource consumption patterns to be reflected by the costing system and find that more diversity in resource consumption patterns only leads to increased costing system sensitivity to errors for some of the aspects of diversity studied. We also identify situations in which allocating costing system refinement resources to cases characterized by high diversity in resource consumption patterns is detrimental to improved accuracy.
Ginger compress therapy for adults with osteoarthritis

therkleson t. (2010) Ginger compress therapy for adults with osteoarthritis. Journal of Advanced Nursing66(10), 2225–2233. Aim This paper is a report of a study to explicate the phenomenon of ginger compresses for people with osteoarthritis. Background Osteoarthritis is claimed to be the leading cause of musculoskeletal pain and disability in Western society. Management ideally combines non-pharmacological strategies, including complementary therapies and pain-relieving medication. Ginger has been applied externally for over a thousand years in China to manage arthritis symptoms. Method Husserlian phenomenological methodology was used and the data were collected in 2007. Ten purposively selected adults who had suffered osteoarthritis for at least a year kept daily diaries and made drawings, and follow-up interviews and telephone conversations were conducted. Findings Seven themes were identified in the data: (1) Meditative-like stillness and relaxation of thoughts; (2) Constant penetrating warmth throughout the body; (3) Positive change in outlook; (4) Increased energy and interest in the world; (5) Deeply relaxed state that progressed to a gradual shift in pain and increased interest in others; (6) Increased suppleness within the body and (7) More comfortable, flexible joint mobility. The essential experience of ginger compresses exposed the unique qualities of heat, stimulation, anti-inflammation and analgesia. Conclusion Nurses could consider this therapy as part of a holistic treatment for people with osteoarthritis symptoms. Controlled research is needed with larger numbers of older people to explore further the effects of the ginger compress therapy.
Learning to Collaborate in a Computer-mediated Setting: Observing a Model Beats Learning from Being Scripted

In an earlier study we had tested if observing a model collaboration or following a collaboration script could improve students' subsequent collaboration in a computer-mediated setting and promote their knowledge of what makes good collaboration. Both model and script showed positive effects. The current study was designed to further probe the effects of model and script by comparing them to conditions (model-plus, script-plus) in which the learning was further supported by providing elaboration support (instructional prompts and guided self-explanation). 40 dyads were tested, 8 in each of the following conditions: model plus elaboration, model, script plus elaboration, script, control. Observing a model collaboration with elaboration support yielded the best results over all other conditions on several measures of the quality of collaborative process and on outcome variables. Model without elaboration was second best. The results for the script conditions were mixed; on some variables even below those of the control condition.
Intergenerational Equity and the Discount Rate for Cost-Benefit Analysis

For two independent principles of intergenerational equity, the implied discount rate equals the growth rate of real per-capital income, say 2%, thus falling right into the range suggested by the U.S. Office of Management and Budget. To prove this, we develop a simple tool to evaluate small policy changes affecting several generations, by reducing the dynamic problem to a static one. A necessary condition is time-invariance, which is statisfied by any common solution concept in an overlapping generations model with exogenous growth. This tool is applied to derive the discount rate for cost-benefit analysis under two different utilitarian welfare functions : classical and relative. It is only with relative utilitarianism that the discount rate is well-defined for a heterogeneous society, is corroborated by an independent principle equation values of human lives, and equals the growth rate of real per-capital income.
Understanding the role of prior product knowledge to information search

Purpose – Existing literature offers conflicting evidence on how prior product knowledge influences amount of information search. A majority of these studies are based on variants of cost benefit frameworks where consumers engage in search until the benefits from information search exceed search costs. The purpose of this paper is to develop an expectancy theory‐based framework to model consumers' information search and its antecedents, including motivation to search as an intervening construct.Design/methodology/approach – The framework is tested using data from real consumers engaged in their actual purchase decisions, in an emerging market context, using longitudinal survey research design. The data are analysed using structural equation modeling to test the hypothesized model. The model shows an acceptable fit with X2 (271, 487)=640.252, p < 0.00 and 0.95 CFI.Findings – Results indicate that the relationship between prior product knowledge to information search is mediated by motivation to search. Pri.
Intention, Emotion, and Action: A Neural Theory Based on Semantic Pointers

We propose a unified theory of intentions as neural processes that integrate representations of states of affairs, actions, and emotional evaluation. We show how this theory provides answers to philosophical questions about the concept of intention, psychological questions about human behavior, computational questions about the relations between belief and action, and neuroscientific questions about how the brain produces actions. Our theory of intention ties together biologically plausible mechanisms for belief, planning, and motor control. The computational feasibility of these mechanisms is shown by a model that simulates psychologically important cases of intention.
Sandpile-based model for capturing magnitude distributions and spatiotemporal clustering and separation in regional earthquakes

Abstract. We propose a cellular automata model for earthquake occurrences patterned after the sandpile model of self-organized criticality (SOC). By incorporating a single parameter describing the probability to target the most susceptible site, the model successfully reproduces the statistical signatures of seismicity. The energy distributions closely follow power-law probability density functions (PDFs) with a scaling exponent of around −1. 6, consistent with the expectations of the Gutenberg–Richter (GR) law, for a wide range of the targeted triggering probability values. Additionally, for targeted triggering probabilities within the range 0.004–0.007, we observe spatiotemporal distributions that show bimodal behavior, which is not observed previously for the original sandpile. For this critical range of values for the probability, model statistics show remarkable comparison with long-period empirical data from earthquakes from different seismogenic regions. The proposed model has key advantages, the foremost of which is the fact that it simultaneously captures the energy, space, and time statistics of earthquakes by just introducing a single parameter, while introducing minimal parameters in the simple rules of the sandpile. We believe that the critical targeting probability parameterizes the memory that is inherently present in earthquake-generating regions.
Adipose tissue‐derived stem cells (ADSCs) transplantation promotes regeneration of expanded skin using a tissue expansion model

Transplantation of adipose tissue‐derived stem cells (ADSCs) is a promising method that has been used in regenerative medicine because it has shown the capacity to accelerate wound healing. However, roles of ADSCs transplantation in expanded‐skin regeneration have remained unknown. To clarify the roles, a tissue expansion model was used in this study. The study comprised three groups of 13 rats in each group: the ADSCs group, the fibroblast (FB) group, and the control group. The skin regeneration in the ADSCs group was enhanced, as evidenced by increased cell proliferation and a higher hydroxyproline content and degree of neovascularization, all with p < 0.05, when compared with both the FB group and the control group. Consistent with enhanced cell proliferation and neovascularization, the regenerated skin in the ADSCs group was much thicker, which further reduced the retraction ratio of the expanded skin. Four weeks after operation, 5'‐bromo‐2'‐deoxyuridine‐labeled ADSCs appeared in subcutaneous tissue, vascular vessels, and hair follicles. The up‐regulation of protein expression, such as epidermal growth factor and vascular endothelial growth factor, primarily emerged in the ADSC group, with the up‐regulated basic fibroblast growth factor appearing in the FB group. Collectively, these results suggest that the transplantation of ADSCs could enhance the regeneration of expanded skin by participating in skin structures and up‐regulating the secretion of epidermal growth factor and vascular endothelial growth factor.
Discrepancies in Clinic and Ambulatory Blood Pressure in Korean Chronic Kidney Disease Patients

Blood pressure (BP) control is considered the most important treatment for preventing chronic kidney disease (CKD) progression and associated cardiovascular complications. However, clinic BP is insufficient to diagnose hypertension (HT) and to monitor overall BP control because it does not correlate well with ambulatory blood pressure monitoring (ABPM). We enrolled 387 hypertensive CKD patients (stages G1–G4, 58.4% male with median age 61 years) from 3 hospitals in Korea. HT of clinic BP and ABPM was classified as ≥ 140/90 and ≥ 130/80 mmHg, respectively. Clinic BP control rate was 60.2%. The median 24-hour systolic blood pressures (SBPs) of CKD G3b and CKD G4 were significantly higher than those of CKD G1–2 and CKD G3a. However, the median 24-hour SBPs were not different between CKD G1–2 and CKD G3a or between CKD G3b and CKD G4. Of all patients, 5.7%, 38.0%. 42.3%, and 14.0% were extreme-dippers, dippers, non-dippers, and reverse-dippers, respectively. Non-/reverse-dippers independently correlated with higher Ca × P product, higher intact parathyroid hormone (iPTH), and lower albumin. Normal BP was 33.3%, and sustained, masked, and white-coat HT were 29.7%, 26.9%, and 10.1%, respectively. White-coat HT independently correlated with age ≥ 61 years and masked HT independently correlated with CKD G3b/G4. In conclusion, ABPM revealed a high prevalence of non-/reverse-dippers and sustained/masked HT in Korean CKD patients. Clinicians should try to obtain a CKD patient's ABPM, especially among those who are older or who have advanced CKD as well as those with abnormal Ca × P product, iPTH, and albumin.
Team Dynamics: A Social Network Perspective

Research has consistently revealed that team cohesion is positively related to team performance under certain conditions. In response to the need for understanding this relationship more fully, and because of the promising new insights that can be garnered with the use of social network analysis (SNA), this study employs SNA as a tool to explore a case study of the structural cohesiveness of two women’s collegiate basketball teams. Members of the two teams completed online roster-based surveys related to different types of structural cohesion levels at four points during the season. This case study revealed that the higher performing team showed improved structural cohesion in the efficacy network over the four phases, and highlighted the movement of key players in the different networks (friendship, trust, advice, and efficacy) over time. These patterns demonstrate the potential for SNA to function as a diagnostic tool for organizations and researchers to generate testable hypotheses even in instances wh.
Full DOF tracking of a hand interacting with an object by modeling occlusions and physical constraints

Due to occlusions, the estimation of the full pose of a human hand interacting with an object is much more challenging than pose recovery of a hand observed in isolation. In this work we formulate an optimization problem whose solution is the 26-DOF hand pose together with the pose and model parameters of the manipulated object. Optimization seeks for the joint hand-object model that (a) best explains the incompleteness of observations resulting from occlusions due to hand-object interaction and (b) is physically plausible in the sense that the hand does not share the same physical space with the object. The proposed method is the first that solves efficiently the continuous, full-DOF, joint hand-object tracking problem based solely on markerless multicamera input. Additionally, it is the first to demonstrate how hand-object interaction can be exploited as a context that facilitates hand pose estimation, instead of being considered as a complicating factor. Extensive quantitative and qualitative experiments with simulated and real world image sequences as well as a comparative evaluation with a state-of-the-art method for pose estimation of isolated hands, support the above findings.
Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages

Src family kinases (SFKs) are non-receptor tyrosine kinases that have been implicated as regulators of the inflammatory response. In this study, the role of SFK activation in the inflammatory response of macrophages to encephalomyocarditis virus (EMCV) infection was examined. Virus infection of macrophages stimulates the expression of cyclooxygenase-2 (COX-2), interleukin (IL)-1β and inducible nitric oxide synthase (iNOS). Inhibition of SFK attenuates EMCV-induced COX-2 expression and prostaglandin E2 production, iNOS expression and subsequent nitric oxide production, and IL-1β expression. EMCV-induced COX-2 expression requires the activation of nuclear factor-κB and the mitogen-activated protein kinase p38. Consistent with these previous findings, inhibition of SFKs attenuated the phosphorylation of p38 in response to EMCV infection, suggesting that SFKs may act upstream of p38. These findings provide evidence that SFK activation plays an active role in the regulation of inflammatory gene expression by virus-infected macrophages.
Sleep Duration and Irregular Bedtime Are Associated with Increased Behavioral Problems among Japanese Preschool-Age Children

127 Received February 7, 2011; revision accepted for publication May 16, 2011. doi: 10.1620/tjem.224. 127 Correspondence: Yoko Komada, Ph.D., Department of Somnology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan. e-mail: ykoma@tokyo-med.ac. jp Short Sleep Duration and Irregular Bedtime Are Associated with Increased Behavioral Problems among Japanese Preschool-Age Children
Processability approach to Arabic l2 teaching and syllabus design

This study aims to identify the relationship between the developmental hierarchy in the acquisition of Arabic as a second language (Arabic L2) and formal classroom instruction. It provides a general presentation of the current debate on the influence of formal instruction in the acquisition of L2. Special attention is given to the subset of Processability Theory (PT) known as Teachability Theory, and its implications for teaching methods of L2 in general and Arabic L2 in particular. This study also provides descriptive information on teaching objectives and materials used by the participants to study Arabic L2. This information is presented in order to establish an explanation for the connection between the formal teaching of Arabic L2 and the processability hierarchy. Participants were nine students studying Arabic as a second language at the Australian National University (three Beginners, three Intermediates, and three Advanced). Interviews were conducted over a period of two teaching semesters during the year 2005. Both implicational and distributional analyses were conducted. The results of these analyses show that teachers and curriculum developers should consider the PT's predicted developmental stages for Arabic L2 structures when developing teaching materials and syllabus.