Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnostic accuracy of the gamma-glutamyl transpeptidase to platelet ratio (GPR) using transient elastography as a reference

We read with great interest the letter from Stockdale et al 1 in which they concluded that the gamma-glutamyl transpeptidase to platelet ratio (GPR) and aspartate transaminase (AST)-to-platelet ratio index (APRI) would not be ideal for the diagnosis of liver fibrosis in patients with HIV–HBV coinfection from West Africa. In a relatively small cohort of HIV–HBV coinfected subjects (n=100) from Ghana, the authors reported poor sensitivity (57%–67%) and specificity (63%–79%) of GRP and APRI in diagnosing advanced fibrosis (≥F3) and cirrhosis (F4). These findings are interesting, but should be interpreted with caution with regards to the internal validity of using transient elastography as the reference, the study population itself and the cut-offs generated as a result. The GPR was originally developed for the assessment of liver fibrosis in HBV mono-infected individuals in a West African setting.2 It has been recently applied to patients predominately treated for HIV–HBV coinfection by a French team, reporting good diagnostic performance to diagnose cirrhosis (sensitivity 77%, specificity 87%). 3 In both studies, the accuracy of GPR was assessed …
Persistence versus Escape: Aspergillus terreus and Aspergillus fumigatus Employ Different Strategies during Interactions with Macrophages

Invasive bronchopulmonary aspergillosis (IBPA) is a life-threatening disease in immunocompromised patients. Although Aspergillus terreus is frequently found in the environment, A. fumigatus is by far the main cause of IBPA. However, once A. terreus establishes infection in the host, disease is as fatal as A. fumigatus infections. Thus, we hypothesized that the initial steps of disease establishment might be fundamentally different between these two species. Since alveolar macrophages represent one of the first phagocytes facing inhaled conidia, we compared the interaction of A. terreus and A. fumigatus conidia with alveolar macrophages. A. terreus conidia were phagocytosed more rapidly than A. fumigatus conidia, possibly due to higher exposure of β-1,3-glucan and galactomannan on the surface. In agreement, blocking of dectin-1 and mannose receptors significantly reduced phagocytosis of A. terreus, but had only a moderate effect on phagocytosis of A. fumigatus. Once phagocytosed, and in contrast to A. fumigatus, A. terreus did not inhibit acidification of phagolysosomes, but remained viable without signs of germination both in vitro and in immunocompetent mice. The inability of A. terreus to germinate and pierce macrophages resulted in significantly lower cytotoxicity compared to A. fumigatus. Blocking phagolysosome acidification by the v-ATPase inhibitor bafilomycin increased A. terreus germination rates and cytotoxicity. Recombinant expression of the A. nidulans wA naphthopyrone synthase, a homologue of A. fumigatus PksP, inhibited phagolysosome acidification and resulted in increased germination, macrophage damage and virulence in corticosteroid-treated mice. In summary, we show that A. terreus and A. fumigatus have evolved significantly different strategies to survive the attack of host immune cells. While A. fumigatus prevents phagocytosis and phagolysosome acidification and escapes from macrophages by germination, A. terreus is rapidly phagocytosed, but conidia show long-term persistence in macrophages even in immunocompetent hosts.
Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera

Diarrheal diseases are a major cause of morbidity and mortality worldwide. In many cases, antibiotic therapy is either ineffective or not recommended due to concerns about emergence of resistance. The pathogenesis of several of the most prevalent infections, including cholera and enteroxigenic Escherichia coli, is dominated by enterotoxins produced by lumen-dwelling pathogens before clearance by intestinal defenses. Toxins gain access to the host through critical host receptors, making these receptors attractive targets for alternative antimicrobial strategies that do not rely on conventional antibiotics. Here, we developed a new nanotechnology strategy as a countermeasure against cholera, one of the most important and prevalent toxin-mediated enteric infections. The key host receptor for cholera toxin, monosialotetrahexosylganglioside (GM1), was coated onto the surface of polymeric nanoparticles. The resulting GM1-polymer hybrid nanoparticles were shown to function as toxin decoys by selectively and stably binding cholera toxin, and neutralizing its actions on epithelial cells in vitro and in vivo. Furthermore, the GM1-coated nanoparticle decoys attenuated epithelial 3’,5’-cyclic adenosine monophosphate production and fluid responses to infection with live Vibrio cholera in cell culture and a murine infection model. Together, these studies illustrate that the new nanotechnology-based platform can be employed as a non-traditional antimicrobial strategy for the management of enteric infections with enterotoxin-producing pathogens.
Rosetta: A Realistic High-Level Synthesis Benchmark Suite for Software Programmable FPGAs

Modern high-level synthesis (HLS) tools greatly reduce the turn-around time of designing and implementing complex FPGA-based accelerators. They also expose various optimization opportunities, which cannot be easily explored at the register-transfer level. With the increasing adoption of the HLS design methodology and continued advances of synthesis optimization, there is a growing need for realistic benchmarks to (1) facilitate comparisons between tools, (2) evaluate and stress-test new synthesis techniques, and (3) establish meaningful performance baselines to track progress of the HLS technology. While several HLS benchmark suites already exist, they are primarily comprised of small textbook-style function kernels, instead of complete and complex applications. To address this limitation, we introduce Rosetta, a realistic benchmark suite for software programmable FPGAs. Designs in Rosetta are fully-developed applications. They are associated with realistic performance constraints, and optimized with advanced features of modern HLS tools. We believe that Rosetta is not only useful for the HLS research community, but can also serve as a set of design tutorials for non-expert HLS users. In this paper we describe the characteristics of our benchmarks and the optimization techniques applied to them. We further report experimental results on an embedded FPGA device as well as a cloud FPGA platform.
The impact of different styles of ‘ leadership ’ and levels of ‘ organisational innovation ’ on ‘ organisational performance ’ : a case of hospitality industry in Thailand

-In the rapidly changing business environment, organisations call for managers capable of adopting innovative knowledge to participate in the digital era. In this research, a total of 419 completed questionnaires were received from managers of hotels in Thailand,exploring the relationship between the demographics of respondents, leadership styles, organisational innovation, and organisational performance. The findings indicate that leadership styles and organisational innovation are associated with organisational performance. In addition, results show that the association between leadership styles and organisational performance is mediated by the organisational innovation. Recommendations for future research and implementation are also discussed. Key-Words: Human Resource Management, Leadership Styles, Organisational Innovation,Organisational Learning, Organisational Performance, Personal Development
Deadline-aware task scheduling for solar-powered nonvolatile sensor nodes with global energy migration

Solar-powered sensor nodes with energy storages are widely used today and promising in the coming trillion sensor era, as they do not require manual battery charging or replacement. The changeable and limited solar power supply seriously affects the deadline miss rates (DMRs) of tasks on these nodes and therefore energy-driven task scheduling is necessary. However, current algorithms focus on the single period (or the current task queue) for high energy utilization and suffer from bad long term DMR. To get better long term DMR, we propose a long term deadline-aware scheduling algorithm with energy migration strategies for distributed super capacitors. Experimental results show that the proposed algorithm reduces the DMR by 27.8% and brings less than 3% of the total energy consumption.
A counterexample to the birational Torelli problem for Calabi–Yau threefolds

The Grassmannian Gr (2,5) is embedded in P9 via the Plücker embedding. The intersection of two general PGL(10) ‐translates of Gr (2,5) is a Calabi–Yau threefold X , and the intersection of the projective duals of the two translates is another Calabi–Yau threefold Y , deformation equivalent to X . Applying results of Kuznetsov and Jiang–Leung–Xie shows that X and Y are derived equivalent, which by a result of Addington implies that their third cohomology groups are isomorphic as polarised Hodge structures. We show that X and Y provide counterexamples to a certain ‘birational’ Torelli statement for Calabi–Yau threefolds, namely, they are deformation equivalent, derived equivalent, and have isomorphic Hodge structures, but they are not birational.
A cancer specific hypermethylation signature of the TERT promoter predicts biochemical relapse in prostate cancer: a retrospective cohort study

The identification of new biomarkers to differentiate between indolent and aggressive prostate tumors is an important unmet need. We examined the role of THOR (TERT Hypermethylated Oncological Region) as a diagnostic and prognostic biomarker in prostate cancer (PCa). We analyzed THOR in common cancers using genome-wide methylation arrays. Methylation status of the whole TERT gene in benign and malignant prostate samples was determined by MeDIP-Seq. The prognostic role of THOR in PCa was assessed by pyrosequencing on discovery and validation cohorts from patients who underwent radical prostatectomy with long-term follow-up data. Most cancers (n = 3056) including PCa (n = 300) exhibited hypermethylation of THOR. THOR was the only region within the TERT gene that is differentially methylated between normal and malignant prostate tissue (p < 0.0001). Also, THOR was significantly hypermethylated in PCa when compared to paired benign tissues (n = 164, p < 0.0001). THOR hypermethylation correlated with Gleason scores and was associated with tumor invasiveness (p = 0.0147). Five years biochemical progression free survival (BPFS) for PCa patients in the discovery cohort was 87% (95% CI 73–100) and 65% (95% CI 52–78) for THOR non-hypermethylated and hypermethylated cancers respectively (p = 0.01). Similar differences in BPFS were noted in the validation cohort (p = 0.03). Importantly, THOR was able to predict outcome in the challenging (Gleason 6 and 7 (3 + 4)) PCa (p = 0.007). For this group, THOR was an independent risk factor for BPFS with a hazard-ratio of 3.685 (p = 0.0247). Finally, THOR hypermethylation more than doubled the risk of recurrence across all PSA levels (OR 2.5, p = 0.02).
Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

BACKGROUND At least 75% of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these factors in the absence of the other with the risk of head and neck cancer is needed to elucidate mechanisms of head and neck carcinogenesis and to assess the efficacy of interventions aimed at controlling either risk factor. METHODS We examined the extent to which head and neck cancer is associated with cigarette smoking among never drinkers and with alcohol drinking among never users of tobacco. We pooled individual-level data from 15 case-control studies that included 10,244 head and neck cancer case subjects and 15,227 control subjects, of whom 1072 case subjects and 5775 control subjects were never users of tobacco and 1598 case subjects and 4051 control subjects were never drinkers of alcohol. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models. All statistical tests were two-sided. RESULTS Among never drinkers, cigarette smoking was associated with an increased risk of head and neck cancer (OR for ever versus never smoking = 2.13, 95% CI = 1.52 to 2.98), and there were clear dose-response relationships for the frequency, duration, and number of pack-years of cigarette smoking. Approximately 24% (95% CI = 16% to 31%) of head and neck cancer cases among nondrinkers in this study would have been prevented if these individuals had not smoked cigarettes. Among never users of tobacco, alcohol consumption was associated with an increased risk of head and neck cancer only when alcohol was consumed at high frequency (OR for three or more drinks per day versus never drinking = 2.04, 95% CI = 1.29 to 3.21). The association with high-frequency alcohol intake was limited to cancers of the oropharynx/hypopharynx and larynx. CONCLUSIONS Our results represent the most precise estimates available of the independent association of each of the two main risk factors of head and neck cancer, and they exemplify the strengths of large-scale consortia in cancer epidemiology.
Moisture in untreated, acetylated, and furfurylated Norway spruce monitored during drying below fiber saturation using time domain NMR.

Using time domain-nuclear magnetic resonance spectroscopy, the moisture content (MC) in Norway spruce [ Picea abies (L.) Karst. ] sapwood, subjected to three different treatments (untreated, acetylated, and furfurylated), was studied during drying at 40°C at MCs below fiber saturation. Spin-spin relaxation time distributions were derived from Carr-Purcell-Meiboom-Gill relaxation curves using mulitexponential fitting (CONTIN). After conditioning for 6 wk at 100% RH, the modified wood samples had a MC of about 15%, whereas the MC of the untreated samples was about 30%. Two water populations with different relaxation times were found in all three sample types at this point: 1.1 ms and 0.15 ms (untreated), 0.5 ms and 0.15 ms (furfurylated), and 1.2 - 3.5 ms and 0.1 ms (acetylated). As the MC decreased, the relaxation time of the most slowly relaxing population decreased, whereas it remained more or less constant for the other population. For both the untreated and the furfurylated samples, the two populations merged at 5 - 10% MC, and relaxation times were identical for the two treatments at low MC. The two populations did not merge for the acetylated samples. These results indicate that while acetylation changed the interaction between water and the wood cell wall, furfurylation seemed to mostly affect the amount of water present within the cell wall at the beginning of the drying experiment.
Three-year safety and efficacy of treating all-comers with newer-generation Resolute Integrity or PROMUS Element stents in the randomised DUTCH PEERS (TWENTE II) trial.

AIMS The aim of this report was to assess the three-year safety and efficacy of implanting newer-generation Resolute Integrity zotarolimus-eluting stents (ZES) versus PROMUS Element everolimus-eluting stents (EES) in all-comers. METHODS AND RESULTS In the randomised, multicentre, investigator-initiated DUTCH PEERS trial, a total of 1,811 all-comers were 1:1 randomly assigned to treatment with ZES versus EES. A total of 1,293 patients (72%) were treated for complex lesions and 455 patients (25%) were treated for multiple lesions. The primary endpoint target vessel failure (TVF) is a composite of cardiac death, target vessel-related myocardial infarction or target vessel revascularisation. Adverse clinical events were independently adjudicated. Three-year follow-up data were obtained in 1,807 patients (99.8%, four withdrawals). Both the ZES and EES groups showed favourable outcomes with a similar incidence of TVF (10.7% vs. 10.3%; pLog-rank=0.77) and the individual components thereof: cardiac death (3.2% vs. 3.1%; pLog-rank=0.87), target vessel-related myocardial infarction (2.8% vs. 2.2%; pLog-rank=0.44) and target vessel revascularisation (6.0% vs. 6.2%; pLog-rank=0.87). In addition, the incidence of definite or probable stent thrombosis was similar for patients treated with ZES versus EES (1.4% vs. 1.1%; pLog-rank=0.66). CONCLUSIONS The safety and efficacy of treating all-comers with newer-generation Resolute Integrity and PROMUS Element stents was found to be extended up to three years.
Application of High-Energy Laser coupled with Gamma – Lonizing Irradiations as New Sterilizing Technique

The present investigations introduce for first time new trend of coupling of two sterilizing sources, high energy Nd-Laser and Gamma – irradiations which has oxidative nature by additional to its thermal effects. The investigated samples will be examined before and after radiations to confirm its internal structure (XRD, microstructure (SEM, AFM, Raman-Spectra) and killing ratio for polluted bacteria. Furthermore some selected biological tests will be checked to be sure from toxicity ratio after radiations. Also many of investigational parameters will be tested such as strength of irradiation dose and irradiation dosage time to achieve maximum healthy sterilizing ratio per minimum time to validate application and wide scale application of this promising sterilizing technique.
Preload, Coefficient of Friction, and Thread Friction in an Implant-Abutment-Screw Complex.

PURPOSE To examine the screw preload, coefficient of friction (COF), and tightening torque needed to overcome the thread friction of an implant-abutment-screw complex. MATERIALS AND METHODS In a customized load frame, 25 new implant-abutment-screw complexes including uncoated titanium alloy screws were torqued and untorqued 10 times each, applying 25 Ncm. RESULTS Mean preload values decreased significantly from 209.8 N to 129.5 N according to the number of repetitions. The overall COF increased correspondingly. There was no comparable trend for the thread friction component. CONCLUSION These results suggest that the application of a used implant-abutment-screw complex may be unfavorable for obtaining optimal screw preload.
New Generation of Resistant Sugar Beet Varieties for Advanced Integrated Management of Cercospora Leaf Spot in Central Europe

Cercospora leaf spot (CLS) epidemics in sugar beet have been increasing in recent years causing higher use of fungicides. Concomitantly, the availability of effective fungicides is at risk because of resistance development in the fungus, the lack of new active ingredients as well as restrictive approval practices. A key option for an integrated management of CLS is cultivation of resistant varieties. Because of the yield penalty in resistant varieties, acceptance in commercial practice so far has been low. The aim of our study was to characterize recent sugar beet varieties registered in Germany in terms of resistance and tolerance to CLS and their value for integrated pest management. The genetic basis of CLS resistance in varieties is protected by intellectual property rights even after variety registration and not open to the public due to economic competition. To gain reliable data for cultivation, varieties have to be tested for their resistance traits under field conditions at varying levels of infection with Cercospora beticola. In collaboration with variety related stakeholders, 15 sugar beet varieties were tested in 49 field trials in Germany from 2014 to 2016 for their yield response to CLS. The trials were set up in a split-plot design with and without infection (i.e., with and without fungicide). The classification of varietal reaction to CLS is based on symptomatic leaf area (susceptibility) and the resulting relative yield loss (tolerance). Since the relation between both parameters varied among varieties, it was used as an additional parameter to describe tolerance. On this basis, three groups of varieties were identified. They can be characterized as a susceptible, a resistant and a presumably tolerant cluster. A comparison of the data with an older dataset originating from 2009 to 2011 revealed that yield performance of recent varieties with resistance to C. beticola caught up with susceptible varieties due to breeding progress. They showed no yield penalty in the absence of the disease and better economic performance than susceptible varieties. It is assumed that these varieties will allow a substantial reduction of fungicide use for an advanced integrated pest management under central European conditions.
Variational approach to the volume viscosity of fluids

The variational principle of Hamilton is applied to develop an analytical formulation to describe the volume viscosity in fluids. The procedure described here differs from those used in the past in that a dissipative process is represented by the chemical affinity and progress variable (sometimes called “order parameter”) of a reacting species. These state variables appear in the variational integral in two places: first, in the expression for the internal energy, and second, in a subsidiary condition accounting for the conservation of the reacting species. As a result of the variational procedure, two dissipative terms appear in the Navier-Stokes equation. The first is the traditional volume viscosity term, proportional to the dilatational component of velocity; the second term is proportional to the material time derivative of the pressure gradient. Values of the respective volume viscosity coefficients are determined by applying the resulting volume-viscous Navier-Stokes equation to the case of acousti.
The Bilateral Filter for Point Clouds

Point sets obtained by 3D scanners are often corrupted with noise, that can have several causes, such as a tangential acquisition direction, changing environmental lights or a reflective object material. It is thus crucial to design efficient tools to remove noise from the acquired data without removing important information such as sharp edges or shape details. To do so, Fleish-man et al. introduced a bilateral filter for meshes adapted from the bilateral filter for gray level images. This anisotropic filter denoises a point with respect to its neighbors by considering not only the distance from the neighbors to the point but also the distance along a normal direction. This simple fact allows for a much better preservation of sharp edges. In this paper, we analyze a parallel implementation of the bilateral filter adapted for point clouds. Source Code The ANSI C++ source code permitting to reproduce results from the on-line demo is available on the web page of the article 1 .
Mechanical properties of Silk fibroin-microcrystalline cellulose composite films

Silk fibroin–microcrystalline cellulose (cellulose whisker) composite films with varied compositions were prepared by casting mixed aqueous solution/suspensions of the two components. Silk fibroin was dissolved in 10M LiSCN followed by dialysis; a cellulose whisker suspension was prepared by sulfuric acid hydrolysis of tunicate cellulose. Macroscopically homogeneous films were obtained at all mixing ratios. While the Young's modulus of the composite films showed a linear, additive dependence on the mixing ratio, the tensile strength and ultimate strain showed a maximum at a 70–80% cellulose content, reaching five times those of fibroin-alone or cellulose-alone films. At the same mixing ratio, infrared spectra of the composite films showed a shift of the amide I peak from 1654 to 1625 cm−1, indicating the conformational change of fibroin from a random coil to a β structure (silk II) at the whisker–matrix interface. This change seems to be induced by contact of fibroin molecules with a highly ordered surface of cellulose whisker. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 3425–3429, 2002