Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of rate-dependent tensile properties of polypropylene fibres used in thermally bonded nonwovens

The stress–strain behaviour of polypropylene fibres is evaluated for various tensile strain rates. Fibre samples are extracted from a thermally bonded nonwoven and fixed in a low-load tensile test machine. A methodology is introduced to implement a constant true strain rate at high strain tests for conventional tensile test machines. The obtained results indicate that polypropylene fibres show a highly viscous behaviour, especially during the initial stage of load application. No significant difference in a tensile behaviour of fibres was observed for loading regimes with a constant true strain rate and a constant engineering strain rate.
Probing exciton propagation and quenching in carbon nanotubes with near‐field optical microscopy

We report on near‐field optical imaging of single‐walled carbon nanotubes (SWNTs), observing photoluminescence (PL) quenching at nanotube ends and defects. The extension of reduced PL reflects the exciton diffusion length of about 100 nm, which can be directly visualized with our technique. Additionally, we model the complete imaging process, including exciton diffusion and tip‐induced rate enhancement, for a deeper understanding of the experimental data and the determination of, e.g. diffusion length and tip enhancement from near‐field PL images.
Interaction of Plasma Homocysteine and Thyroid Hormone Concentrations in the Pathogenesis of the Slow Coronary Flow Phenomenon

Background and Objective: The slow coronary flow (SCF) phenomenon is an angiographic observation and a well-recognized clinical entity characterized by delayed opacification of vessels in a normal coronary angiogram due to reasons yet unclear. Thyroid hormones exert significant effects on plasma homocysteine (Hcy) levels and microvascular resistance. Recently, several investigators have consistently reported that elevation of the plasma Hcy level can severely disturb vascular endothelial function and play a role in the pathogenesis of SCF. Accordingly, we investigated the levels of plasma Hcy and thyroid hormones and their relationship in patients with SCF. Method: Forty-four patients with angiographically proven SCF (Group I) (mean age 55.5 ± 10.4 years, 26 males) and 44 cases with normal coronary flow (NCF) pattern (Group II) (mean age 53.9 ± 11 years, 22 males) with similar risk profiles were enrolled in the study. Coronary flow patterns of the cases were determined by the thrombolysis in myocardial infarction (TIMI) frame count method. The coronary TIMI frame counts were calculated separately for each coronary artery and their average was determined as the mean TIMI frame count for each subject. Serum levels of free tri-iodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH) and Hcy were measured. Patients with thyroid disease or on medications with a potential to affect thyroid functions were excluded. Results: There were no statistically significant differences between the groups concerning the demographic characteristics and major cardiovascular risk factors. Mean TIMI frame counts of SCF and NCF groups were 45.9 ± 12 and 23.3 ± 3.7, respectively. fT4 (ng/dl) and TSH (µIU/ml) levels of the two groups were similar (p > 0.05). The level of fT3, the active metabolite of the thyroid hormone family, was dramatically reduced in the SCF group when compared to the NCF group (2.3 ± 0.2 vs. 3.0 ± 0.3, p = 0.0001, respectively). Plasma Hcy levels of patients with SCF were found to be significantly higher than controls (12.2 ± 4.9 vs. 8.5 ± 2.9, p = 0.0001, respectively). Correlation analysis showed a significant negative correlation between the plasma fT3 and Hcy levels and the mean TIMI frame counts (r = –0.31, p = 0.003 vs. r = –0.66, p = 0.0001). Moreover, there was a significant positive correlation between the plasma Hcy levels and the mean TIMI frame counts (r = 0.58, p = 0.0001). Also, fT3 was the only significant determinant of the variance of Hcy in multiple regression analysis (r = –0.30, p = 0.005). Conclusion: fT3 levels were decreased and plasma Hcy levels were increased significantly in patients with SCF as compared to controls. This finding suggests that thyroid hormones and/or (? ) a possible disturbance in their metabolism may be responsible for the elevated levels of plasma Hcy in patients with SCF and may play a role in the pathogenesis of the SCF phenomenon.
Named Entity Translation with Web Mining and Transliteration

This paper presents a novel approach to improve the named entity translation by combining a transliteration approach with web mining, using web information as a source to complement transliteration, and using transliteration information to guide and enhance web mining. A Maximum Entropy model is employed to rank translation candidates by combining pronunciation similarity and bilingual contextual co-occurrence. Experimental results show that our approach effectively improves the precision and recall of the named entity translation by a large margin.
A comparative study on DC flashover characteristics of iced insulators with various electrial test methods

In this paper, the DC flashover characteristics of iced insulator strings were explored in the multi-functional artificial climate chamber through four methods, namely, the average flashover voltage method, the minimum flashover voltage method, the maximum withstand method and the 50% withstand method, with the typical DC porcelain insulator strings and composite insulators. The results indicated that the average flashover voltage and the minimum flashover voltage obtained respectively by the average flashover voltage method and the minimum flashover voltage method were in normal distribution; the 50% flashover voltages gained by the two test methods mentioned above were about 8.0%~9.8% and 3.8%~5.9% higher than that gained by the 50% withstand method respectively, which justified the feasibility of employing the U-curve method and the average flashover voltage method to study the flashover characteristics of iced insulators and their affecting factors.
Decrease in Dengue virus-2 infection and reduction of cytokine/chemokine production by Uncaria guianensis in human hepatocyte cell line Huh-7

ABSTRACT BACKGROUND Dengue fever may present hemorrhages and cavitary effusions as result of exacerbated immune responses. We investigated hydro-alcoholic extracts from leaves (UGL) and bark (UGB) of the medicinal species Uncaria guinanensis with respect to antiviral effects in Dengue virus (DENV) infection and in immunological parameters associated with in vivo physiopathological features. METHODS Chemical profiles from UGB or UGL were compared in thin layer chromatography and 1H nuclear magnetic resonance using flavonoid compounds and a pentacyclic oxindole alkaloid-enriched fraction as references. DENV-2-infected hepatocytes (Huh-7) were treated with extracts. Cell viability, DENV antigens and immunological factors were detected by enzyme-linked immunosorbent assay (ELISA) or flow cytometry. FINDINGS The UGL mainly differed from UGB by selectively containing the flavonoid kaempferitrin. UGB and UGL improved hepatocyte viability. Both extracts reduced intracellular viral antigen and inhibited the secretion of viral non-structural protein (NS1), which is indicative of viral replication. Reduction in secretion of macrophage migration inhibitory factor was achieved by UGB, of interleukin-6 by UGL, and of interleukin-8 by both UGB and UGL. MAIN CONCLUSIONS The U. guianensis extracts presented, antiviral and immunomodulatory effects for DENV and possibly a hepatocyte-protective activity. Further studies may be performed to consider these products as potential candidates for the development of an herbal product for the future treatment of dengue.
High Expression of PRL-3 Promotes Cancer Cell Motility and Liver Metastasis in Human Colorectal Cancer

Purpose: Overexpression of PRL-3 has been implicated in colorectal cancer metastases. We investigated the significance of PRL-3 expression in the progression and development of colorectal cancer. Experimental Design: We transfected PRL-3-specific small interfering RNA into human colon cancer DLD-1 cells and analyzed its effect on proliferation, motility, and hepatic colonization. Using an in situ hybridization method, we examined the levels of PRL-3 expression in both primary (177 cases) and metastatic (92 cases) human colorectal cancers and elucidated the relationships with clinicopathological parameters including the incidence of metachronous liver and/or lung metastasis after curative surgery for primary tumor. Results: Transient down-regulation of PRL-3 expression in DLD-1 cells abrogated motility (in vitro) and hepatic colonization (in vivo), but no effect on the proliferation of these cells was observed. In human primary colorectal cancers, the frequency of up-regulated PRL-3 expression in cases with liver (84.4%) or lung (88.9%) metastasis was statistically higher than that in cases without either type of metastasis (liver, 35.9%; lung, 42.3%). In metastatic colorectal cancer lesions, high expression of PRL-3 was frequently detected (liver, 91.3%; lung, 100%). Interestingly, metachronous metastasis was observed more frequently in the cases with high PRL-3 expression (P < 0.0001). Conclusions: These results indicate that PRL-3 expression in colorectal cancers may contribute to the establishment of liver metastasis, particularly at the step in which cancer cells leave the circulation to extravasate into the liver tissue. In addition, PRL-3 is expected to be a promising biomarker for identifying colorectal cancer patients at high risk for distant metastases.
Treatment-Seeking for Tuberculosis-Suggestive Symptoms: A Reflection on the Role of Human Agency in the Context of Universal Health Coverage in Malawi

Tuberculosis (TB) is highly infectious and one of the leading killers globally. Several studies from sub-Saharan Africa highlight health systems challenges that affect ability to cope with existing disease burden, including TB, although most of these employ survey-type approaches. Consequently, few address community or patient perspectives and experiences. At the same time, understanding of the mechanisms by which the health systems challenges translate into seeking or avoidance of formal health care remains limited. This paper applies the notion of human agency to examine the ways people who have symptoms suggestive of TB respond to and deal with the symptoms vis-à-vis major challenges inherent within health delivery systems. Empirical data were drawn from a qualitative study exploring the ways in which notions of masculinity affect engagement with care, including men’s well-documented tendency to delay in seeking care for TB symptoms. The study was carried out in three high-density locales of urban Blantyre, Malawi. Data were collected in March 2011 –March 2012 using focus group discussions, of which eight (mixed sex = two; female only = three; male only = three) were with 74 ordinary community members, and two (both mixed sex) were with 20 health workers; and in-depth interviews with 20 TB patients (female = 14) and 20 un-investigated chronic coughers (female = eight). The research process employed a modified version of grounded theory. Data were coded using a coding scheme that was initially generated from the study aims and subsequently progressively amended to incorporate concepts emerging during the analysis. Coded data were retrieved, re-read, and broken down and reconnected iteratively to generate themes. A myriad of problems were described for health systems at the primary health care level, centring largely on shortages of resources (human, equipment, and drugs) and unprofessional conduct by health care providers. Participants consistently pointed out how the problems could drive patients from promptly reporting symptoms at primary healthcare centres. The accounts suggest that in responding to illness symptoms including those suggestive of TB, patients navigate their options taking into cognisance past and current experiences with formal health systems. Understanding and factoring in the mediating role of such ‘agency’ is critical when implementing efforts to promote timely response to TB-suggestive symptoms.
[11C]arachidonic acid incorporation measurement in human brain: Optimization for clinical use

Arachidonic acid (AA) is involved in signal transduction, neuroinflammation, and production of eicosanoid metabolites. The AA brain incorporation coefficient (K*) is quantifiable in vivo using [11C]AA positron emission tomography, although repeatability remains undetermined. We evaluated K* estimates obtained with population‐based metabolite correction (PBMC) and image‐derived input function (IDIF) in comparison to arterial blood‐based estimates, and compared repeatability. Eleven healthy volunteers underwent a [11C]AA scan; five repeated the scan 6 weeks later, simulating a pre‐ and post‐treatment study design. For all scans, arterial blood was sampled to measure [11C]AA plasma radioactivity. Plasma [11C]AA parent fraction was measured in 5 scans. K* was quantified using both blood data and IDIF, corrected for [11C]AA parent fraction using both PBMC (from published values) and individually measured values (when available). K* repeatability was calculated in the test‐retest subset. K* estimates based on blood and individual metabolites were highly correlated with estimates using PBMC with arterial input function (r = 0.943) or IDIF (r = 0.918) in the subset with measured metabolites. In the total dataset, using PBMC, IDIF‐based estimates were moderately correlated with arterial input function‐based estimates (r = 0.712). PBMC and IDIF‐based K* estimates were ∼6.4% to ∼11.9% higher, on average, than blood‐based estimates. Average K* test‐retest absolute percent difference values obtained using blood data or IDIF, assuming PBMC for both, were between 6.7% and 13.9%, comparable to other radiotracers. Our results support the possibility of simplified [11C]AA data acquisition through eliminating arterial blood sampling and metabolite analysis, while retaining comparable repeatability and validity.
Single Intraperitoneal Injection of Monocrotaline as a Novel Large Animal Model of Chronic Pulmonary Hypertension in Tibet Minipigs

Objective The purpose of this study was to establish an animal model of chronic pulmonary hypertension with a single-dose intraperitoneal injection of monocrotaline (MCT) in young Tibet minipigs, so as to enable both invasive and noninvasive measurements and hence facilitate future studies. Methods Twenty-four minipigs (8-week-old) were randomized to receive single-dose injection of 12.0 mg/kg MCT (MCT group, n = 12) or placebo (control group, n = 12 each). On day 42, all animals were evaluated for pulmonary hypertension with conventional transthoracic echocardiography, right heart catheterization (RHC), and pathological changes. Findings of these studies were compared between the two groups. Results At echocardiography, the MCT group showed significantly higher pulmonary arterial mean pressure (PAMP) compared with the controls (P<0.001). The pulmonary valve curve showed v-shaped signals with reduction of a-waves in minipigs treated with MCT. In addition, the MCT group had longer pulmonary artery pre-ejection phases, and shorter acceleration time and ejection time. RHC revealed higher mean pulmonary arterial pressure (mPAP) in the MCT group than in the control group (P<0.01). A significant and positive correlation between the mPAP values and the PAMP values (R = 0.974, P<0.0001), and a negative correlation between the mPAP and ejection time (R = 0.680, P<0.0001) was noted. Pathology demonstrated evidence of pulmonary vascular remodeling and higer index of right ventricular hypertrophy in MCT-treated minipigs. Conclusion A chronic pulmonary hypertension model can be successfully established in young minipigs at six weeks after MCT injection. These minipig models exhibited features of pulmonary arterial hypertension that can be evaluated by both invasive (RHC) and noninvasive (echocardiography) measurements, and may be used as an easy and stable tool for future studies on pulmonary hypertension.
Phenotype of Cloned Mice: Development, Behavior, and Physiology

Cloning technology has potential to be a valuable tool in basic research, clinical medicine, and agriculture. However, it is critical to determine the consequences of this technique in resulting offspring before widespread use of the technology. Mammalian cloning using somatic cells was first demonstrated in sheep in 1997 and since then has been extended to a number of other species. We examined development, behavior, physiology, and longevity in B6C3F1 female mice cloned from adult cumulus cells. Control mice were naturally fertilized embryos subjected to the same in vitro manipulation and culture conditions as clone embryos. Clones attained developmental milestones similar to controls. Activity level, motor ability and coordination, and learning and memory skills of cloned mice were comparable with controls. Interestingly, clones gained more body weight than controls during adulthood. Increased body weight was attributable to higher body fat and was associated with hyperleptinemia and hyperinsulinemia indicating that cloned mice are obese. Cloned mice were not hyperphagic as adults and had hypersensitive leptin and melanocortin signaling systems. Longevity of cloned mice was comparable with that reported by the National Institute on Aging and the causes of death were typical for this strain of mouse. These studies represent the first comprehensive set of data to characterize cloned mice and provide critical information about the long-term effects of somatic cell cloning.
Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence

To examine the relationship between macrophage tropism and neurovirulence, macaques were inoculated with two recombinant hybrid viruses derived from the parent viruses SIVmac239, a lymphocyte-tropic, non-neurovirulent clone, and SIV/17E-Br, a macrophage-tropic, neurovirulent virus strain. The first recombinant, SIV/17E-Cl, contained the portion of the env gene that encodes the surface glycoprotein and a short segment of the transmembrane glycoprotein of SIV/17E-Br in the backbone of SIVmac239. Unlike SIVmac239, SIV/17E-Cl replicated productively in macrophages, demonstrating that sequences in the surface portion of env determine macrophage tropism. None of five macaques inoculated with SIV/17E-Cl developed simian immunodeficiency virus (SIV) encephalitis. The second recombinant, SIV/17E-Fr, which contained the entire env and nef genes and the 3' long terminal repeat of SIV/17E-Br in the SIVmac239 backbone, was also macrophage tropic. Six of nine macaques inoculated with SIV/17E-Fr developed SIV encephalitis ranging from mild to moderate in severity, indicating a significant (P = 0.031) difference in the neurovirulence of the two recombinants. In both groups of macaques, CD4+ cell counts declined gradually during infection and there was no significant difference in the rate of the decline between the two groups of macaques. This study demonstrated that macrophage tropism alone is not sufficient for the development of neurological disease. In addition, it showed that while sequences in the surface portion of the envelope gene determine macrophage tropism, additional sequences derived from the transmembrane portion of envelope and/or nef confer neurovirulence.
Real-time 3D walking pattern generation for a biped robot with telescopic legs

Meltran V, a new biped robot with telescopic legs, is introduced. For 3D walking control of the robot we analyze the dynamics of a three-dimensional inverted pendulum in which motion is constrained to move along an arbitrarily defined plane. From this analysis we obtain simple linear dynamics, the three-dimensional linear inverted pendulum mode (3D-LIPM). Using a real-time control method based on 3D-LIPM, the Meltran V robot successfully demonstrated 3D dynamic walking without the use of any prepared trajectories.
Vitamin D as an adjuvant in melanoma therapy.

, so the only reliable therapy is proper surgical excision when the disease is localized to the skin.Therefore, the management of meta-static melanoma represents a significant challenge for both clinicians and patients, and there is an urgent need to clarify the mechanisms responsible for resistance to therapy against metastatic melanoma . These challenges undoubtedly will be addressed by basic and clinical melanoma researchers for years to come. However, to help patients with these devastating diseases we need immediate, nontoxic and economical adjuvant strategies for improvement of patient survival, with rela -tively limited side effects. These require-ments can be met by the application of natural products and their derivatives in an educated fashion, to not only restrict mel -anoma growth and progression but also to restore the body’s homeostatic capabilities to control tumor behavior
Humeral fracture in a Japanese Black calf repaired by closed approach and two methods of external skeletal fixation

A healthy 71-day-old female Japanese Black calf was evaluated for fracture of the left humerus. The left humeral fracture was treated by closed repair and unilateral external skeletal fixation (ESF) with an epoxy putty fixator. The calf was active, and eight days after surgery slipped and fell, resulting in breakage of the ESF. The calf underwent repair by transfixation pinning and casting (TPC), which is an alternative to the ESF method. The TPC was removed 37 days after the first surgery, and the calf could bear weight on the left forelimb while walking. This case suggests that recovery after closed repair with TPC for a humeral fracture in an active calf can be successfully managed on the farm.
Equivalence of Topological Form for Curvilinear Geometric Objects

Given a curvilinear geometric object in R3, made up of properly-joined parametric patches defined in terms of control points, it is of interest to know under what conditions the object will retain its original topological form when the control points are perturbed. For example, the patches might be triangular BΘzier surface patches, and the geometric object may represent the boundary of a solid in a solid-modeling application. In this paper we give sufficient conditions guaranteeing that topological form is preserved by an ambient isotopy. The main conditions to be satisfied are that the original object should be continuously perturbed in a way that introduces no self-intersections of any patch, and such that the patches remain properly joined. The patches need only have C0 continuity along the boundaries joining adjacent patches. The results apply directly to most surface modeling schemes, and they are of interest in several areas of application.
Individual differences in the influence of phonological characteristics on expressive vocabulary development by young children

The current study attempts to differentiate effects of phonotactic probability (i.e. the likelihood of occurrence of a sound sequence), neighbourhood density (i.e. the number of phonologically similar words), word frequency, and word length on expressive vocabulary development by young children. Naturalistic conversational samples for three children (age 1;4–3;1) were obtained from CHILDES. In a backward regression analysis, phonotactic probability, neighbourhood density, word frequency, and word length were entered as possible predictors of ages of first production of words for each child. Results showed that the factors affecting first production of words varied across children and across word types. Specifically, word length affected ages of first production for all three children, whereas the other three variables affected only one child each. The implications of these findings for models of expressive vocabulary development are discussed.