Miracle-dz/UniFAR-FTUs huggingface dataset:
Distribution of Aeromonas phenospecies and genospecies among strains isolated from water, foods or from human clinical samples

Summary A total of 332 Aeromonas spp. originating from drinking water (n = 75), fresh water (n = 57), chicken and ground beef (107), human faecal samples in association with travelling (n = 49), human faecal samples not associated with travelling (n = 38), and six strains from human blood cultures were studied by phenotypic methods and by using analysis of ribopatterns as a molecular method for the identification of the 13 known hybridization groups (HGs). Also included were the reference strains of each HG. A. hydrophila HG 1, A. caviae HG 4 and A. veronii biotype sobria HG 8/10 were the most important genospecies identified in human faecal samples. A. hydrophila HG 2 and A. media HG 5B predominated in drinking water and A. hydrophila HG 2 and HGS, A. media HG 5A and HG 5B predominated in fresh water. In drinking water only one isolate was A. hydrophila HG 1 and two isolates were A. caviae HG 4. Clinically important Aeromonas spp. HG 1 (A. hydrophila), HG 4 (A. caviae) and HG 8/10 (A. veronii biotype sobria) were common in chicken and ground beef. In contrast to the drinking water samples, HG 5A was common in chicken and ground beef samples. Atypical, unidentified isolates were most often found in fresh water samples (12/57 strains). Although water has been suspected of being an important source of human aeromonas infections, clinically important HGs were found to be in the minority among Aeromonas spp. identified in drinking water or fresh water. The distribution of Aeromonas spp. HGs among drinking water, chicken and ground beef samples was also different, suggesting that contamination of meat or chicken may not originate from water.
Broadcasting on Large Scale Heterogeneous Platforms under the Bounded Multi-Port Model

We consider the classical problem of broadcasting a large message at an optimal rate in a large scale distributed network under the multi-port communication model. In this context, we are interested in both building an overlay network and providing an explicit algorithm for scheduling the communications. From an optimization point of view, we aim both at maximizing the throughput (i.e., the rate at which nodes receive the message) and minimizing the degree of the participating nodes, i.e., the number of TCP connections they must handle simultaneously. The main novelties of our approach are the introduction of this degree constraint and the classification of the set of participating nodes into two parts: open nodes that stay in the open-Internet and “guarded” nodes that lie behind firewalls or NATs. Two guarded nodes cannot communicate directly, but rather need to use an open node as a gateway for transmitting a message. In the case without guarded nodes, we prove that it is possible to reach the optimal throughput, at the price of a quasi-optimal (up to a small additive increase) degree of the participating nodes. In presence of guarded nodes, our main contributions are a closed form formula for the optimal cyclic throughput and the proof that the optimal solution may require arbitrarily large degrees. In the acyclic case, we propose an algorithm that reaches the optimal throughput with low degree. Then, we prove a worst case ratio between the optimal acyclic and cyclic throughput and show through simulations that this ratio is on average very close to 1, what makes acyclic solutions efficient both in terms of throughput maximization and degree minimization.
Quality improvement and cost savings after implementation of the Leapfrog intensive care unit physician staffing standard at a community teaching hospital

Background: Prior studies have shown that implementation of the Leapfrog intensive care unit physician staffing standard of dedicated intensivists providing 24-hr intensive care unit coverage reduces length of stay and in-hospital mortality. A theoretical model of the cost-effectiveness of intensive care unit physician staffing patterns has also been published, but no study has examined the actual cost vs. cost savings of such a program. Objective: To determine whether improved outcomes in specific quality measures would result in an overall cost savings in patient care Design: Retrospective, 1 yr before-after cohort study Setting: A 15-bed mixed medical-surgical community intensive care unit Patients: A total of 2,181 patients: 1,113 patients preimplementation and 1,068 patients postimplementation. Intervention: Leapfrog intensive care unit physician staffing standard Measurements: Intensive care unit and hospital length of stay, rates for ventilator-associated pneumonia and central venous access device infection, and cost of care. Results: Following institution of the intensive care unit physician staffing, the mean intensive care unit length of stay decreased significantly from 3.5±8.9 days to 2.7±4.7 days, (p < .002). The frequency of ventilator-associated pneumonia fell from 8.1% to 1.3% (p < .0002) after intervention. Ventilator-associated pneumonia rate per 100 ventilator days decreased from 1.03 to 0.38 (p < .0002). After intervention, the frequency of the central venous access device infection events fell from 9.4% to 1.1% (p < .0002). Central venous access device infection rate per 1000 line days decreased from 8.49 to 1.69. The net savings for the hospital were $744,001. The 1-yr institutional return on investment from intensive care unit physician staffing was 105%. Conclusions: Implementation of the Leapfrog intensive care unit physician staffing standard significantly reduced intensive care unit length of stay and lowered the prevalence of ventilator-associated pneumonia and central venous access device infection. A cost analysis yielded a 1-yr institutional return on investment of 105%. Our study confirms that implementation of the Leapfrog intensive care unit physician staffing model in the community hospital setting improves quality measures and is economically feasible.
The Fatal Conceit: The Errors of Socialism

Hayek gives the main arguments for the free-market case and presents his manifesto on the "errors of socialism. " Hayek argues that socialism has, from its origins, been mistaken on factual, and even on logical, grounds and that its repeated failures in the many different practical applications of socialist ideas that this century has witnessed were the direct outcome of these errors. He labels as the "fatal conceit" the idea that "man is able to shape the world around him according to his wishes. " "The achievement of "The Fatal Conceit" is that it freshly shows why socialism must be refuted rather than merely dismissed--then refutes it again. "--David R. Henderson, "Fortune. " "Fascinating. The energy and precision with which Mr. Hayek sweeps away his opposition is impressive. "--Edward H. Crane, "Wall Street Journal" F. A. Hayek is considered a pioneer in monetary theory, the preeminent proponent of the libertarian philosophy, and the ideological mentor of the Reagan and Thatcher "revolutions. "
Early childhood intervention and early adolescent social and emotional competence: second-generation evaluation evidence from the Chicago Longitudinal Study

Background: To explore whether social or emotional outcomes for high-risk early adolescent youth that attended an established preventive intervention called the Chicago Child–Parent Center Preschool Program (CPC) are moderated by individual, family and program variations. Purpose: Two questions are addressed: (1) Do the effects of CPC preschool participation on early adolescent social and emotional competency vary by sex of child, family risk status, parent education and family structure? (2) Do estimated effects on early adolescent social and emotional competency vary by program length in the preschool and school-age components of the program? Programme description: Located in or close to elementary schools in the Chicago public school system, the CPC program provides educational and family-support services to children between the ages of 3 and 9 (preschool to 2nd or 3rd grade). Within a structure of comprehensive services similar to Head Start, the intervention emphasises the acquisition of basic skills in language arts and math through relatively structured but diverse learning experiences that include teacher-directed, whole-class instruction, small-group and individualised activities, and frequent field trips. Sample: Data for this investigation were drawn from the Chicago Longitudinal Study (CLS). The CLS follows a cohort of 1539 disadvantaged, minority children (93% African-American, 7% Latino or Other) who were born in 1980 and attended kindergarten programs within the Chicago Public School System in 1985/86. Out of the full sample of 1539, a subset of 989 children (64% of the sample) received preschool services from one of Chicago's 20 Child–Parent Center (CPC) programs. An additional set of 550 children (36% of the sample) did not attend CPC preschool and serve as a non-CPC comparison group. The study sample are 1378 primarily African-American youth who participated in the CLS and had scores for two or more identifiable social and emotional competency indicators by age 15. Design and methods: Follow-up of a non-randomised alternative intervention matched-group cohort at age 15 years. Differential effects were estimated using multiple regression. Program interaction terms (e.g., program × sex or program × parent high school graduate) were added to the basic regression model specification that already included the main effects of each variable included in the interaction. Results: Some 12% (or 11 of 92) of the interaction terms for social and emotional outcomes by age 15 were significant at the 0.01 or 0.05 level. The most frequently detected differential effects were for family risk level (high or low) and sex of child. Conclusions: Most children appear to benefit equally from participation in the CPC program. The prediction from ecological theory that children experiencing a large number of environmental risk factors (e.g., high family risk status and low parental education levels) are more likely to benefit from program participation was supported.
Globalizing Media Ethics? An Assessment of Universal Ethics Among International Political Journalists

In response to recent scholarship on the need for universal professional values, a call that has intensified in the post-9/11 world, this article reports how journalists in Asia and the Middle East conceptualize universal professional values and the possible impact of a universal ethics code. In general, the journalists interviewed for this study were suspicious of a Western-imposed set of values or a code. However, they agreed on a core set of values, ones that de-emphasized truth telling in relation to respect and the need to maintain a community. They also emphasized that different political systems make the implementation of a universal code problematic. However, there was great agreement on the need for such discussion within the profession and on the commonalities such discussion reveals.
Naturalness or Biodiversity: Negotiating the Dilemma of Intervention in Swedish Protected Area Management

Whether and how to intervene in nature to maintain or restore values is a contested issue among scholars within ecological restoration, protected area management and environmental ethics, but also among the practitioners and public officials who shape how nature is actually managed. This article analyses how the issue of intervention is debated in the case of protected forest area management in Sweden, a country with a traditionally strong preservationist discourse centred on maintaining areas as ‘untouched’ as possible. The analysis shows how this traditional view is challenged by a more interventionist discourse centred on adaptive management for biodiversity, but also how there are still attempts to reaffirm a preservationist discourse and practice. The implications of this as-yet-unsettled debate are discussed, concluding by pointing to a need to examine critically not only the older preservationist discourse and ‘naturalness', but also the ascendant interventionist discourse and ‘biodiversity'.
HIGHLIGHTED TOPIC Regulation of Protein Metabolism in Exercise and Recovery Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women

Mette Hansen, Mads Kongsgaard, Lars Holm, Dorthe Skovgaard, S. Peter Magnusson, Klaus Qvortrup, Jytte O. Larsen, Per Aagaard, Morten Dahl, Annette Serup, Jan Frystyk, Allan Flyvbjerg, Henning Langberg, and Michael Kjaer Institute of Sports Medicine, Bispebjerg Hospital, and Faculty of Health Sciences, University of Copenhagen, Copenhagen; The Medical Research Laboratories, Clinical Institute and Medical Department M (Diabetes and Endocrinology), Aarhus University Hospital, Aarhus; Department of Medical Anatomy, Faculty of Health Sciences and Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark; and Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark
Postnatal Development of Intrinsic and Synaptic Properties Transforms Signaling in the Layer 5 Excitatory Neural Network of the Visual Cortex

Information flow in neocortical circuits is regulated by two key parameters: intrinsic neuronal properties and the short-term activity-dependent plasticity of synaptic transmission. Using multineuronal whole-cell voltage recordings, we characterized the postnatal maturation of the electrophysiological properties and short-term plasticity of excitatory synaptic transmission between pairs of layer 5 (L5) pyramidal neurons (n = 158) in acute slices of rat visual cortex over the first postnatal month. We found that the intrinsic and synaptic properties of L5 pyramidal neurons develop in parallel. Before postnatal day 15 (P15), intrinsic electrophysiological properties were tuned to low-frequency operation, characterized by high apparent input resistance, a long membrane time constant, and prolonged somatic action potentials. Unitary excitatory synaptic potentials were of large amplitude (P11–P15; median, 514 μV), but showed pronounced use-dependent depression during prolonged regular and physiologically relevant presynaptic action potential firing patterns. In contrast, in mature animals we observed a developmental decline of the peak amplitude of unitary EPSPs (P25–P29; median, 175 μV) paralleled by a decrease in apparent input resistance, membrane time constant, and somatic action potential duration. Notably, synaptic signaling of complex action potential firing patterns was also transformed, with P25–P29 connections faithfully signaling action potential trains at frequencies up to 40 Hz (1st to 50th action potential ratio, 0.91 ± 0.12). Postnatal refinement of intrinsic properties and short-term plasticity therefore transforms the capacity of the L5 excitatory neural network of the visual cortex to generate and process patterns of action potential firing and contribute to network activity.
A PROSPECTIVE MULTICENTER STUDY OF CHILDHOOD ENCEPHALITIS IN GREECE

Encephalitis is associated with significant childhood morbidity and mortality worldwide, however not much is known about the contemporary epidemiology and outcome. In this prospective multicenter pediatric encephalitis study conducted in Greece for 3 years, 42 cases were diagnosed and the presumptively or definitely causative pathogen was identified in 24 (57.1%). Leading pathogens included herpes viruses (10 patients), enteroviruses (6), and Streptococcus pneumoniae (2). No fatalities were observed; however, deficits remained in 5 of 42 (11.9%) children.
Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis

Mnt is a Max‐interacting transcriptional repressor that has been hypothesized to function as a Myc antagonist. To investigate Mnt function we deleted the Mnt gene in mice. Since mice lacking Mnt were born severely runted and typically died within several days of birth, mouse embryo fibroblasts (MEFs) derived from these mice and conditional Mnt knockout mice were used in this study. In the absence of Mnt, MEFs prematurely entered the S phase of the cell cycle and proliferated more rapidly than Mnt+/+ MEFs. Defective cell cycle control in the absence of Mnt is linked to upregulation of Cdk4 and cyclin E and the Cdk4 gene appears to be a direct target of Mnt–Myc antagonism. Like MEFs that overexpress Myc, Mnt−/− MEFs were prone to apoptosis, efficiently escaped senescence and could be transformed with oncogenic Ras alone. Consistent with Mnt functioning as a tumor suppressor, conditional inactivation of Mnt in breast epithelium led to adenocarinomas. These results demonstrate a unique negative regulatory role for Mnt in governing key Myc functions associated with cell proliferation and tumorigenesis.
Mucosal Healing in Ulcerative Colitis--When Zero is Better.

BACKGROUND AND AIMS Extensive evidence has underlined the importance of mucosal healing as a treatment aim for ulcerative colitis (UC). We aimed to assess differences in the incidence of clinical relapse at 12 months between UC patients with Mayo endoscopic scores (MES) 0 and 1. METHODS This retrospective study included consecutive patients in corticosteroid-free remission between 2008 and 2013 and with follow-up of at least 1 year, with MES 0 or 1 in complete colonoscopy. Clinical relapse was defined as need for induction treatment, treatment escalation, hospitalization or surgery. A p value <0.05 was considered statistically significant. RESULTS The study included 138 patients, 72 (52.2%) female, with mean age of 49 (±14) years. Inflammatory activity was classified as MES 0 in 61 (44.2%) patients and MES 1 in 77 (55.8%) patients. Clinical relapse during follow-up was significantly more frequent in patients with MES 1 than MES 0 (27.3 vs 11.5%, p = 0.022), and in the multivariate analysis MES 1 was the only factor significantly associated with an increased risk of relapse (odds ratio 2.89, 95% confidence interval 1.14-7.36, p = 0.026). This association was encountered in the subgroup of patients with left-sided/extensive colitis (29.7 vs 11.1%, p = 0.049), but not proctitis (25.0 vs 12.0%, p = 0.202). CONCLUSIONS In patients with UC in corticosteroid-free remission, particularly those with left-sided colitis or extensive colitis, MES 1 was significantly associated with a 3-fold increased risk of relapse compared with endoscopic MES 0. Our results support the use of endoscopic MES 0 as the most suitable treatment endpoint to define mucosal healing in patients with UC.
Accounting and popular culture: framing a research agenda

Purpose - The objective of this paper is to recognize the richness in exploring the inter-linkages between accounting and popular culture. Such an investigation should reap returns in not only furthering an understanding of accounting, but also the ways and means in which notions of accountability and audit permeate our everyday lives. In addition, it attempts to capture the significant transformative influence of accounting, and calculative practices more generally, in the actual shaping of the contours of the cultural context. Finally, it briefly introduces the six papers in this AAAJ special issue. Design/methodology/approach - The paper draws on literature from the fields of both accounting and cultural studies to set out a theoretically informed framework for the future examination of the myriad ways in which accounting is entwined with the popular. Findings - The paper argues a case for the study of accounting within the domain of popular culture, proposes two theoretical lenses from which to examine the inter-linkages between these two disciplines, and presents a diverse range of research possibilities for further scholarly inquiry in the field. Originality/value - Traditionally regarded as trivial and unworthy of academic attention, research into the regular rituals that pervade the everyday is now a legitimate field of scholarly inquiry among social and cultural theorists. Accounting researchers, however, have remained relatively aloof from this general trend, preferring to seek solace in the sphere of the corporation rather than the coffee shop. This paper is novel in that it attempts to broaden the scope of accounting scholarship into the new domain of popular culture.
Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Hepcidin regulates serum iron levels, and its dosage is used in differential diagnostic of iron-related pathologies. We used the data collected in the HEPMEN (named after HEPcidin during MENses) study to investigate the joint dynamics of serum hepcidin and iron during the menstrual cycle in healthy women. Ninety menstruating women were recruited after a screening visit. Six fasting blood samples for determination of iron-status variables were taken in the morning throughout the cycle, starting on the second day of the period. Non-linear mixed effect models were used to describe the evolution of iron and hepcidin. Demographic and medical covariates were tested for their effect on model parameters. Parameter estimation was performed using the SAEM algorithm implemented in the Monolix software. A general pattern was observed for both hepcidin and iron, consisting of an initial decrease during menstruation, followed by a rebound and stabilising during the second half of the cycle. We developed a joint model including a menstruation-induced decrease of both molecules at the beginning of the menses and a rebound effect after menses. Iron stimulated the release of hepcidin. Several covariates, including contraception, amount of blood loss and ferritin, were found to influence the parameters. The joint model of iron and hepcidin was able to describe the fluctuations induced by blood loss from menstruation in healthy non-menopausal women and the subsequent regulation. The HEPMEN study showed fluctuations of iron-status variables during the menstrual cycle, which should be considered when using hepcidin measurements for diagnostic purposes in women of child-bearing potential.
Self-reported attention deficit and hyperactivity disorder symptoms among university students in Eldoret, Kenya.

OBJECTIVE To determine the prevalence of self-reported attention deficit and hyperactivity disorder (ADHD) symptoms among university students in Eldoret, Kenya. DESIGN A cross-sectional descriptive study of all students who gave consent to participate in the study. SETTING Moi University's Town Campus, comprising the Schools of Medicine, Dentistry and Public Health. SUBJECTS Four hundred and fifty eight undergraduate students, with a mean age of 23.7 years (17-46, S.D. 4.1), of whom 236 (51.5%) were male. MAIN OUTCOME MEASURES Presence of ADHD symptoms as measured by the adult ADHD self-report scale (ASRS versus 1.1). RESULTS The prevalence rate of self-reported ADHD symptoms was 21.8%. This was significantly associated with belonging to a younger age-group (17-20 years) compared to the older age-groups (p<0.05). The prevalence was higher among females (25.2%) than among males (18.6%), but this was not statistically significant. There was no significant association between a positive ASRS screen and course of study. Using a modification of ASRS full symptom checklist to approximate a DSM IV TR ADHD diagnosis yielded a prevalence of ADHD symptoms of 9.2% in this cohort. CONCLUSION The prevalence rate of ADHD symptoms among university students in Eldoret, Kenya is significantly higher than that reported in other studies. Further studies are needed to generate more information about this condition in the low-income countries, especially in college and university populations.