Miracle-dz/UniFAR-FTUs huggingface dataset:
A TAM-based model for e-government: a case for Turkey

E-government initiatives are extensively used around the world. In recent years, e-government applications have been widely used in Turkey to provide public services in electronic environment. Much of previous research on e-government adoption mainly concentrates on technology adoption in volitional environments and technology adoption in mandatory environments is lacking in previous literature. Thus, this study develops a technology acceptance model (TAM)-based model for a mandatory system in Turkish public institutions. The success of the theoretical model is tested on Sgb.Net system, the use of which is mandatory in Turkish public institutions. The constructs of the model are mandatory use, management support, training support, attitude, perceived usefulness, perceived ease of use and use. Empirical results reveal that the theoretical model can be used to measure mandatory technology use in e-government in Turkey and other countries.
Computed diffusion-weighted MR imaging may improve tumor detection.

PURPOSE To describe computed diffusion weighted (DW) magnetic resonance (MR) imaging as a method for obtaining high-b-value images from DW MR imaging performed at lower b values and to investigate the feasibility of the technique to improve lesion detection in oncologic cases. MATERIALS AND METHODS The study was approved by the institutional and research committee, and written informed consent was obtained from all patients. DW MR imaging was performed on a CuSO(4) phantom at 1.5 T with a range of b values and compared with computed DW MR imaging images synthesized from lower b values (0 and 600 sec/mm(2)). The signal-to-noise ratio (SNR) was compared, and agreement between the SNR of computed DW MR imaging and theoretical estimation assessed. Computed DW MR imaging was evaluated in 10 oncologic patients who underwent whole-body DW MR imaging with b values of 0 and 900 sec/mm(2). Computed DW MR images at computed b values of 1500 and 2000 sec/mm(2) were generated. The image quality and background suppression of acquired and computed images were rated by a radiologist using a four-point scale. The diagnostic performance for malignant lesion detection using these images was evaluated and compared by using the McNemar Test. RESULTS The SNR of computed DW MR imaging of the phantom conformed closely to theoretical predictions. Computed DW MR imaging resulted in a higher SNR compared with acquired DW MR imaging, especially at b values greater than 840 sec/mm(2). In patients, images with a computed b value of 2000 sec/mm(2) produced good image quality and high background suppression (mean scores of 2.8 and 4.0, respectively). Evaluation of images with a computed b value of 2000 sec/mm(2) resulted in higher overall diagnostic sensitivity (96.0%) and specificity (96.6%) compared with images with an acquired b value of 900 sec/mm(2) (sensitivity, 89.4%; specificity, 87.5%; P < .01). CONCLUSION Computed DW MR imaging in the body allows higher-b-value images to be obtained with a good SNR. Clinical computed DW MR imaging is feasible and may improve disease detection. SUPPLEMENTAL MATERIAL http://radiology.rsna. org/lookup/suppl/doi:10.1148/radiol.11101919/-/DC1.
The Edit Distance Transducer in Action: The University of Cambridge English-German System at WMT16

This paper presents the University of Cambridge submission to WMT16. Motivated by the complementary nature of syntactical machine translation and neural machine translation (NMT), we exploit the synergies of Hiero and NMT in different combination schemes. Starting out with a simple neural lattice rescoring approach, we show that the Hiero lattices are often too narrow for NMT ensembles. Therefore, instead of a hard restriction of the NMT search space to the lattice, we propose to loosely couple NMT and Hiero by composition with a modified version of the edit distance transducer. The loose combination outperforms lattice rescoring, especially when using multiple NMT systems in an ensemble.
The relationship between computer games and quality of life in adolescents

Background: Term of doing computer games among teenagers is growing rapidly. This popular phenomenon can cause physical and psychosocial issues in them. Therefore, this study examined the relationship between computer games and quality of life domains in adolescents aging 12-15 years. Materials and Methods: In a cross-sectional study using the 2-stage stratified cluster sampling method, 444 male and female students in Borkhar were selected. The data collection tool consisted of 1) World Health Organization Quality Of Life – BREF questionnaire and 2) personal information questionnaire. The data were analyzed by Pearson correlation, Spearman correlation, chi-square, independent t-tests and analysis of covariance. Findings: The total mean score of quality of life in students was 67.11±13.34. The results showed a significant relationship between the age of starting to play games and the overall quality of life score and its fourdomains (range r=–0.13 to –0.18). The mean of overall quality of life score in computer game users was 68.27±13.03 while it was 64.81±13.69 among those who did not play computer games and the difference was significant (P=0.01). There were significant differences in environmental and mental health domains between the two groups (P<0.05). However, there was no significant relationship between BMI with the time spent and the type of computer games. Conclusion: Playing computer games for a short time under parental supervision can have positive effects on quality of life in adolescents. However, spending long hours for playing computer games may have negative long-term effects.
The use of patient-specific measurement instruments in the process of goal-setting: a systematic review of available instruments and their feasibility

Objective: The aim of this study was to identify the currently available patient-specific measurement instruments used in the process of goal-setting and to assess their feasibility. Methods: After a systematic search in PubMed, EMBASE, CINAHL, PsychINFO and REHABDATA, patient-specific instruments were included, structured in a goal-setting practice framework and subjected to a qualitative thematic analysis of feasibility. Results: A total of 25 patient-specific instruments were identified and 11 were included. These instruments can be used for goal negotiation, goal-setting and evaluation. Each instrument has its own strengths and weaknesses during the different phases of the goal-setting process. Objective feasibility data were revealed for all instruments such as administration time, instruction, training and availability. Subjective feasibility could only be analysed for the Canadian Occupational Performance Measure, Goal Attainment Scaling, Self-Identified Goal Assessment and Talking Mats. Relevant themes were that Canadian Occupational Performance Measure and Goal Attainment Scaling were time consuming and difficult for patients with cognitive problems, but they facilitated goal-setting in a client-centred approach. Talking Mats was especially feasible for patients with cognitive and communication impairments. Conclusions: A total of 11 instruments were identified, and although some had strong points, there is no single good instrument that can be recommended specifically. Applying a combination of the strengths of the available instruments within a goal-setting framework can improve goal setting and tailor it to individual patients.
The 5-year relative survival rate of stomach cancer in the USA, Europe and Japan.

In order to compare survival rates in Japan with those in the USA and European countries, we abstracted the 5-year relative survival rate from several data sources. Survival rates of cancer diagnosed in 1995–99 in the USA were abstracted from 18 cancer registries in the Surveillance, Epidemiology and End Results (SEER) data (1). Survival rates of cancer diagnosed in 1995–99 in the UK and Norway were obtained from three cancer registries (Norway, the UK: Northern Ireland, the UK: Scotland and the UK: Wales) in the European Network of Cancer Registries data (2), and the rate of cancer diagnosed in 2000–02 in Japan was reported from six cancer registries (Miyagi, Yamagata, Niigata, Fukui, Osaka and Nagasaki) in the monitoring of cancer incidence in Japan (MCIJ) project (3). Here, we compared the survival rate of stomach cancer coded as C16 (ICD10). Figure 1 shows the 5-year relative survival rate of stomach cancer by age category for males; Fig. 2 shows these data for females. The 5-year relative survival rates for males across all age groups were about the same as those for females. The rates for both sexes slightly decrease as the patients age. Males and females showed different trends. The survival rates declined constantly according to age for males, while the survival rates for females remain at the same level until the age group 65–74 years, then fell rapidly after the age 75 years. The survival rate in Japan was clearly higher than those in the other countries for both sexes; the rates ranged from 50% to 70%. The other countries showed a similar trend; the rates ranged from 10% to 30%. The high survival rate for Japanese patients could be related to the organized stomach cancer screening and abundant experience in treatment according to the high incidence rate in the country.
Subunit Vaccination of Mice against New World Cutaneous Leishmaniasis: Comparison of Three Proteins Expressed in Amastigotes and Six Adjuvants

ABSTRACT A mixture of well-defined recombinant antigens together with an adjuvant that preferentially stimulates specific gamma interferon (IFN-γ)-secreting helper type 1 CD4+ T cells (Th1 cells) presents a rational option for a vaccine against leishmaniasis. The potential of this approach was investigated in murine infections withLeishmania mexicana, which are characterized by the absence of a parasite-specific Th1 response and uncontrolled parasite proliferation. A mixture of three antigens (glycoprotein 63, cysteine proteinases, and a membrane-bound acid phosphatase), which are all expressed in amastigotes, the mammalian stage of the parasite, were used for the immunization of C57BL/6 mice in combination with six adjuvants (interleukin 12 [IL-12], Detox, 4′-monophosphoryl lipid A, QS-21, Mycobacterium bovis BCG, and Corynebacterium parvum). All six vaccine formulations containing the mixture of recombinant antigens were protective against challenge infections with promastigotes, the insect stage of the parasite, in that mice controlled and healed infections but developed transient and, in certain cases, accentuated disease. The most effective adjuvants were IL-12 followed by Detox. Further studies using these two adjuvants showed that a similar protective effect was observed with a mixture of the corresponding native proteins, and mice which had controlled the infection showed a preponderance of IFN-γ-secreting CD4+T cells in the lymph nodes draining the lesion. Using the recombinant proteins individually, it is shown that the relatively abundant cysteine proteinases and glycoprotein 63, but not the acid phosphatase, are able to elicit a protective response. The results are discussed in comparison to previous studies with subunit vaccines and with respect to cell biological aspects of antigen presentation inLeishmania-infected macrophages.
Sociocultural factors predicting subjective experience of emotion:a collective level analysis

A research synthesis was conducted with six studies which correlated self-ratings of emotion (affect balance or pleasantness-unplesantness and emotional intensity) with the nations' socio-economic, ecological and cultural characteristics (Individualism, Masculinity, Uncertainty Avoidance and Power Distance national scores in Hofstede's dimensions). The meta-analysis shows that power distance and uncertainty avoidance has an homogenous significant and medium effect size with unpleasantness of emotional experience. Cultural masculinity shows a medium-low homogeneous effect size on emotional unpleasantness. Individualism shows a non homogenous positive association with emotional pleasantness. Multivariate analyses show that power distance was related to lower social desirability and intensity of positive and negative emotions. Results support the assumption that high power distance cultures deemphasize emotional experience by normative means. Uncertainty avoidance shows a positive association with emotional intensity. Hume's assumption that climatic effects on the subjective experience of emotions disappear when social and cultural factors are taken into account was supported.
An Extended 3-D Radiosity–Graphics Combined Model for Studying Thermal-Emission Directionality of Crop Canopy

Radiosity-graphics combined model (RGM) has been proposed to calculate the radiation regime and bidirectional reflectance distribution function of complex 3D scene, which is limited in visible and near-infrared wavelength (0.3-3 mum) region. In this paper, RGM is extended to thermal region (named as TRGM) based on thermal-radiosity theory and thermal-emission directionality of vegetation canopy. The TRGM has been implemented on Microsoft Windows platform, and a parameterization scheme for crop canopies is introduced in this paper. It is then evaluated by comparing with two row-crop directional thermal emission models and one thermal radiative-transfer model. Field experiment data has been used to validate the TRGM for row structural wheat and maize canopies. The root mean square error of directional brightness temperature (DBT) is smaller than 1.0degC for the wheat canopy and 0.5degC for the maize canopy while the canopy DBTs vary more than 4degC. Model sensitivity analyses have also been conducted to illustrate influences of component temperature distribution, component emissivity, incident atmospheric radiation, and canopy structure on the crop canopy DBT.
Redox properties of protein disulfide isomerase (dsba) from escherichia coli

The redox properties of periplasmic protein disulfide isomerase (DsbA) from Escherichia coli were analyzed by measuring the equilibrium constant of the oxidation of reduced DsbA by oxidized glutathione. The experiments are based on the finding that the intrinsic tryptophan fluorescence of DsbA increases about threefold upon reduction of the enzyme, which can be explained by the catalytic disulfide bridge quenching the fluorescence of a neighboring tryptophan residue. From the specific fluorescence of DsbA equilibrated in the presence of different ratios of reduced and oxidized glutathione at pH 7, an equilibrium constant of 1.2 × 10−4 M was determined, corresponding to a standard redox potential (E'0) of DsbA of ‐0.089 V. Thus, DsbA is a significantly stronger oxidant than cytoplasmic thioredoxins and its redox properties are similar to those of eukaryotic protein disulfide isomerase. The equilibrium constants for the DsbA/glutathione equilibrium were found to be strongly dependent on pH and varied from 2.5 × 10−3 M to 3.9 × 10−5 M between pH 4 and 8.5. The redox state‐dependent fluorescence properties of DsbA should allow detailed physicochemical studies of the enzyme as well as the quantitative determination of the oxidized protein by fluorescence titration with dithiothreitol and open the possibility to observe bacterial protein disulfide isomerase “at work” during catalysis of oxidative protein folding.
Effects of Maternal diabetes on Embryogenesis

Through the use of the in vitro technique of mammalian whole embryo culture, the factors and mechanisms responsible for the increased incidence of congenital malformations among infants of diabetic mothers have been investigated. During early stages of embryogenesis, serum from streptozotocin-induced diabetic rats, hyperglycemia, hypoglycemia, hyperketonemia (beta-hydroxybutyrate), and low molecular weight somatomedin inhibitors are teratogenic or growth inhibitory, or both. Furthermore, combinations of these factors interact to increase the risk of a malformation occurring. In contrast, other factors, such as hyperinsulinemia and excess leucine, palmitic acid, and acetoacetate, have little or no teratogenic potential. Mechanisms of action of the factors are varied and may include alterations of arachidonic acid metabolism (hyperglycemia), glycolysis (hypoglycemia), DNA synthesis (beta-hydroxybutyrate), and embryonic nutrition (somatomedin inhibitors). The results demonstrate that the origin of the diabetic embryopathy is multifactorial, that many of the congenital defects are induced early in gestation before the diabetic woman may realize she is pregnant, and that insulin therapy reduces the risk.
Autonomous regulation of the insect gut by circadian genes acting downstream of juvenile hormone signaling

In temperate regions, the shortening day length informs many insect species to prepare for winter by inducing diapause. The adult diapause of the linden bug, Pyrrhocoris apterus, involves a reproductive arrest accompanied by energy storage, reduction of metabolic needs, and preparation to withstand low temperatures. By contrast, nondiapause animals direct nutrient energy to muscle activity and reproduction. The photoperiod-dependent switch from diapause to reproduction is systemically transmitted throughout the organism by juvenile hormone (JH). Here, we show that, at the organ-autonomous level of the insect gut, the decision between reproduction and diapause relies on an interaction between JH signaling and circadian clock genes acting independently of the daily cycle. The JH receptor Methoprene-tolerant and the circadian proteins Clock and Cycle are all required in the gut to activate the Par domain protein 1 gene during reproduction and to simultaneously suppress a mammalian-type cryptochrome 2 gene that promotes the diapause program. A nonperiodic, organ-autonomous feedback between Par domain protein 1 and Cryptochrome 2 then orchestrates expression of downstream genes that mark the diapause vs. reproductive states of the gut. These results show that hormonal signaling through Methoprene-tolerant and circadian proteins controls gut-specific gene activity that is independent of circadian oscillations but differs between reproductive and diapausing animals.
The 25 October 2010 Mentawai tsunami earthquake (Mw 7.8) and the tsunami hazard presented by shallow megathrust ruptures

The 25 October 2010 Mentawai, Indonesia earthquake (Mw 7.8) ruptured the shallow portion of the subduction zone seaward of the Mentawai islands, off‐shore of Sumatra, generating 3 to 9 m tsunami run‐up along southwestern coasts of the Pagai Islands that took at least 431 lives. Analyses of teleseismic P, SH and Rayleigh waves for finite‐fault source rupture characteristics indicate ∼90 s rupture duration with a low rupture velocity of ∼1.5 km/s on the 10° dipping megathrust, with total slip of 2–4 m over an ∼100 km long source region. The seismic moment‐scaled energy release is 1.4 × 10−6, lower than 2.4 × 10−6 found for the 17 July 2006 Java tsunami earthquake (Mw 7.8). The Mentawai event ruptured up‐dip of the slip region of the 12 September 2007 Kepulauan earthquake (Mw 7.9), and together with the 4 January 1907 (M 7.6) tsunami earthquake located seaward of Simeulue Island to the northwest along the arc, demonstrates the significant tsunami generation potential for shallow megathrust ruptures in regions up‐dip of great underthrusting events in Indonesia and elsewhere.
BL-7010 Demonstrates Specific Binding to Gliadin and Reduces Gluten-Associated Pathology in a Chronic Mouse Model of Gliadin Sensitivity

Celiac disease (CD) is an autoimmune disorder in individuals that carry DQ2 or DQ8 MHC class II haplotypes, triggered by the ingestion of gluten. There is no current treatment other than a gluten-free diet (GFD). We have previously shown that the BL-7010 copolymer poly(hydroxyethyl methacrylate-co-styrene sulfonate) (P(HEMA-co-SS)) binds with higher efficiency to gliadin than to other proteins present in the small intestine, ameliorating gliadin-induced pathology in the HLA-HCD4/DQ8 model of gluten sensitivity. The aim of this study was to investigate the efficiency of two batches of BL-7010 to interact with gliadin, essential vitamins and digestive enzymes not previously tested, and to assess the ability of the copolymer to reduce gluten-associated pathology using the NOD-DQ8 mouse model, which exhibits more significant small intestinal damage when challenged with gluten than HCD4/DQ8 mice. In addition, the safety and systemic exposure of BL-7010 was evaluated in vivo (in rats) and in vitro (genetic toxicity studies). In vitro binding data showed that BL-7010 interacted with high affinity with gliadin and that BL-7010 had no interaction with the tested vitamins and digestive enzymes. BL-7010 was effective at preventing gluten-induced decreases in villus-to-crypt ratios, intraepithelial lymphocytosis and alterations in paracellular permeability and putative anion transporter-1 mRNA expression in the small intestine. In rats, BL-7010 was well-tolerated and safe following 14 days of daily repeated administration of 3000 mg/kg. BL-7010 did not exhibit any mutagenic effect in the genetic toxicity studies. Using complementary animal models and chronic gluten exposure the results demonstrate that administration of BL-7010 is effective and safe and that it is able to decrease pathology associated with gliadin sensitization warranting the progression to Phase I trials in humans.
Use of internal and external sources of knowledge and innovation in the Canadian wine industry

Using a sample of 146 Canadian wine-producing firms, I analyze the link between knowledge sources and innovation by examining the way in which different strategies influence a firm's capacity for innovation. I then examine which innovation strategies are more strongly linked to innovation and the extent to which there are differences amongst wine-producing regions in Canada. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd. Resume La recherche a ete conduite sur un echantillon de 146 entreprises canadiennes de l'industrie viticole. J'analyse le lien entre l'utilisation de sources de connaissance et l'innovation en examinant la maniere dont differentes strategies influencent la capacite d'innovation des entreprises viticoles. Par la suite, j'examine les strategies d'innovation qui sont les plus fortement associees a l'innovation et les differences au sein des regions viticoles canadiennes. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.