Miracle-dz/UniFAR-FTUs huggingface dataset:
Albumin synthesis in premature neonates is stimulated by parenterally administered amino acids during the first days of life.

BACKGROUND We recently showed that parenteral administration of amino acids to premature infants immediately after birth is safe and results in a positive nitrogen balance and increased whole-body protein synthesis. However, we did not determine organ-specific effects; albumin, produced by the liver, is an important protein, but its concentration is often low in premature neonates during the first few days after birth. OBJECTIVE The objective of the study was to test the hypothesis that the fractional and absolute albumin synthesis rates would increase with the administration of amino acids after birth, even at low nonprotein energy intake. DESIGN Premature infants (<1500 g birth weight), who were on ventilation, received from birth onward either glucose only (control group, n = 7) or glucose and 2.4 g amino acid kg(-1) d(-1) (intervention group, n = 8). On postnatal day 2, all infants received a primed continuous infusion of [1-(13)C]leucine, and mass spectrometry techniques were used to determine the incorporation of the leucine into albumin. Results are expressed as medians and 25th and 75th percentiles. RESULTS Albumin fractional synthesis rates in the intervention group were significantly higher than those in the control group [22.9% (17.6-28.0%)/d and 12.6% (11.0-19.4%)/d, respectively; P = 0.029]. Likewise, the albumin absolute synthesis rates in the intervention group were significantly higher than those in the control group [228 (187-289) mg kg(-1) d(-1) and 168 (118-203) mg kg(-1) d(-1), respectively; P = 0.030]. CONCLUSION Amino acid administration increases albumin synthesis rates in premature neonates even at a low energy intake.
Introducing a new component of the metabolic syndrome: low cholesterol absorption.

BACKGROUND Weight reduction is the recommended treatment of obese type 2 diabetes, but the effects of weight reduction on cholesterol metabolism are poorly understood. OBJECTIVE We investigated glucose, cholesterol, and lipoprotein metabolism at baseline and 2 y after weight reduction in obese patients with type 2 diabetes consuming an isoenergetic diet. DESIGN Sixteen subjects were randomly chosen to consume a very-low-energy or low-energy diet for 3 mo, after which they consumed a weight-maintenance diet for up to 2 y. Cholesterol absorption and metabolism, LDL and HDL kinetics, and variables of glucose metabolism were studied at baseline and 2 y. RESULTS Baseline serum sex hormone binding globulin (SHBG) was significantly related to cholesterol absorption efficiency, and serum glucose and insulin concentrations were associated with cholesterol synthesis. After 2 y, body weight was reduced by 6 +/- 1 kg (P < 0.01), body mass index by 6% (P < 0.05), and blood glucose by 14% (P < 0.01); the ratio of serum SHBG to insulin increased by 66% (P < 0.05). Serum and VLDL, LDL, and HDL triacylglycerol were significantly reduced by 13-24%. Despite unchanged serum concentrations of cholesterol, cholesterol absorption efficiency and the ratio of serum plant sterols to cholesterol-indicators of cholesterol absorption-increased by 28% (P < 0.01) and 20-31% (P < 0. 05 for both), respectively; the fractional removal of LDL apolipoprotein B decreased. Fecal excretion of cholesterol as neutral sterols decreased significantly by 11%. Changes in body weight were significantly negatively correlated with changes in ratios of cholesterol to serum plant sterols and cholestanol. CONCLUSIONS Baseline cholesterol absorption and synthesis were related to respective serum SHBG, glucose, and insulin values. Weight reduction increased cholesterol absorption and improved variables of glucose metabolism. These results suggest that low cholesterol absorption and high synthesis may be part of the insulin resistance syndrome.
TREATMENT OF RLS AND PLMS DISORDER IN ADULTS: PRACTICE PARAMETERS

An important update in the recommendation about the use of rotigotine for the treatment of signs and symptoms associated with moderate-to-severe primary restless legs syndrome (RLS) is included in a letter to the editor that was published after the American Academy of Sleep Medicine (AASM) Board of Directors approved the practice parameters. This letter to the editor is an essential supplement to the practice parameters document:
Self-Verification as a Mediator of Mothers’ Self-Fulfilling Effects on Adolescents’ Educational Attainment

This research examined whether self-verification acts as a general mediational process of self-fulfilling prophecies. The authors tested this hypothesis by examining whether self-verification processes mediated self-fulfilling prophecy effects within a different context and with a different belief and a different outcome than has been used in prior research. Results of longitudinal data obtained from mothers and their adolescents (N = 332) indicated that mothers’ beliefs about their adolescents’ educational outcomes had a significant indirect effect on adolescents’ academic attainment through adolescents’ educational aspirations. This effect, observed over a 6-year span, provided evidence that mothers’ self-fulfilling effects occurred, in part, because mothers’ false beliefs influenced their adolescents’ own educational aspirations, which adolescents then self-verified through their educational attainment. The theoretical and applied implications of these findings are discussed.
Recognizing Eating from Body-Worn Sensors

Automated dietary monitoring solutions that can find when, what, and how much individuals consume are needed for many applications such as providing feedback to individuals with chronic disease. Advances in body-worn sensors have led to systems with high accuracy for finding meals and even which foods are consumed in each bite. However, most tests are done in controlled lab settings with restricted meal choices, little background noise, and subjects focused on eating. For these systems to be adopted by users it is critical that they work well in realistic situations and be able to handle confounding factors such as background noise, shared meals, and multi-tasking. Work in realistic environments usually has lower accuracy, but has challenges in determining ground truth. Most critically, there has been a significant gap between lab and free-living environments. This is compounded by data usually being collected for different individuals in each setting, making it difficult to determine how the accuracy gap can be closed. We present a multi-modality study on eating recognition, using body-worn motion (head, wrists) and audio (earbud microphone) sensors for 12 participants (6 from the lab study, 6 new to test generalizability). In contrast to the lab, where audio alone has the highest accuracy, we find now that a combination of sensing modalities (audio, motion) is needed; yet sensor placement (head vs. wrist) is not critical. We further find that lab data does generalize to other participants, but while personal free-living data improves accuracy, more data from others can actually lead to worse performance.
Rolling Nagoya Mouse Strain (PROD-rol/rol) with Classic Piebald Mutation

ABSTRACT Ataxic rolling Nagoya (PROD-rol/rol) mice, which carry a mutation in the α1 subunit of the Cav2.1 channel (Cacna1a) gene, were discovered in 1969. They show white spots on agouti coat and have a mutation in the piebald spotting (s) locus. However, mutation analysis of the s locus encoding the endothelin receptor type B (Ednrb) gene in PROD-rol/rol mice had not been performed. Here, we examined the genomic and mRNA sequences of the Ednrb gene in PROD-rol/rol and wild-type rolling Nagoya (PROD-s/s) and studied the expression patterns of Ednrb and Cacna1a genes in these mice in comparison with C57BL/6J mice. Polymerase chain reaction analyses revealed two silent nucleotide substitutions in the coding region and insertion of a retroposon-like element in intron 1 of the Ednrb gene. Expression analyses demonstrated similar localizations and levels of Ednrb and Cacna1a expression in the colon between PROD-rol/rol and PROD-s/s mice, but the expression levels of both genes were diminished compared with C57BL/6J mice. Microsatellite genotyping showed that at least particular regions of chromosome 14 proximal to the Ednrb locus of the PROD strain were derived from Japanese fancy piebald mice. These results indicated that PROD-rol/rol mice have two mutant genes, Ednrb and Cacna1a. As no PROD strain had an intact Ednrb gene, using congenic rolling mice would better serve to examine rolling Nagoya-type Cav2.1 channel dysfunctions.
IDENTIFICATION OF A COMPLETE 160 μm FLUX-LIMITED SAMPLE OF INFRARED GALAXIES IN THE ISO LOCKMAN HOLE 1 deg2 DEEP FIELDS: SOURCE PROPERTIES AND EVIDENCE FOR STRONG EVOLUTION IN THE FIR LUMINOSITY FUNCTION FOR ULIRGs

We have identified a complete, flux-limited (S160>120 mJy) sample of 160 μm selected sources from Spitzer observations of the 1 deg2 Infrared Space Observatory (ISO) Deep Field region in the Lockman Hole (LH). Ground-based UV, optical, and near-infrared (NIR) photometry and optical spectroscopy have been used to determine colors, redshifts, and masses for the complete sample of 40 galaxies. Spitzer-IRAC+MIPS photometry, supplemented by ISOPHOT data at 90 μm and 170 μm, has been used to calculate accurate total infrared luminosities, LIR(8–1000 μm), and to determine the IR luminosity function (LF) of luminous infrared galaxies (LIRGs). The maximum observed redshift is z ∼ 0.80 and the maximum total infrared luminosity is log (LIR/L☉) = 12.74. Over the luminosity range log (LIR/L☉) = 10–12, the LF for LIRGs in the LH Deep Field is similar to that found previously for local sources at similar infrared luminosities. The mean host galaxy mass, log (M/M☉) = 10.7, and dominance of H ii-region spectral types, is also similar to what has been found for local LIRGs, suggesting that intense starbursts likely power the bulk of the infrared luminosity for sources in this range of LIR. However for the most luminous sources, log (LIR/L☉)>12.0, we find evidence for strong evolution in the LF ∝(1 + z)6±1, assuming pure number density evolution. These ultraluminous infrared galaxies (ULIRGs) have a larger mean host mass, log (M/M☉) = 11.0, and exhibit disturbed morphologies consistent with strong interactions/mergers, and they are also more likely to be characterized by starburst–active galactic nucleus (AGN) composite or AGN spectral types.
FOCUSR: Feature Oriented Correspondence Using Spectral Regularization--A Method for Precise Surface Matching

Existing methods for surface matching are limited by the tradeoff between precision and computational efficiency. Here, we present an improved algorithm for dense vertex-to-vertex correspondence that uses direct matching of features defined on a surface and improves it by using spectral correspondence as a regularization. This algorithm has the speed of both feature matching and spectral matching while exhibiting greatly improved precision (distance errors of 1.4 percent). The method, FOCUSR, incorporates implicitly such additional features to calculate the correspondence and relies on the smoothness of the lowest-frequency harmonics of a graph Laplacian to spatially regularize the features. In its simplest form, FOCUSR is an improved spectral correspondence method that nonrigidly deforms spectral embeddings. We provide here a full realization of spectral correspondence where virtually any feature can be used as an additional information using weights on graph edges, but also on graph nodes and as extra embedded coordinates. As an example, the full power of FOCUSR is demonstrated in a real-case scenario with the challenging task of brain surface matching across several individuals. Our results show that combining features and regularizing them in a spectral embedding greatly improves the matching precision (to a submillimeter level) while performing at much greater speed than existing methods.
Acute Myocardial Infarction.

Acute myocardial infarction is being recognized as a spectrum of clinical subsets. This appreciation has been brought about to a large degree by the development of several new tools that can be applied clinically to aid in evaluation of patients with acute infarction, and in some cases to provide shortand long-term prognostic information. In the realm of noninvasive methods, several tests utilizing radiopharmaceuticals and scintillation cameras have emerged and are rapidly becoming reliable diagnostic parameters in patients with coronary disease and infarction. Technetium 99m (stannous) pyrophosphate (TcPYP) scintigraphy, one of the first of these techniques to find clinical use, has been shown to be an accurate indicator of acute transmural myocardial infarction and provides added sensitivity and specificity to the diagnosis. Increased diagnostic accuracy, the dimension of visible localization and the potential for infarct sizing promise physicians better understanding of
Expected loss analysis for authentication in constrained channels

We derive bounds on the expected loss for authentication protocols in channels which are constrained due to noisy conditions and communication costs. This is motivated by a number of authentication protocols, where at least some part of the authentication is performed during a phase, lasting n rounds, with no error correction. This requires assigning an acceptable threshold for the number of detected errors and taking into account the cost of incorrect authentication and of communication. This paper describes a framework enabling an expected loss analysis for all the protocols in this family. Computationally simple methods to obtain nearly optimal values for the threshold, as well as for the number of rounds are suggested and upper bounds on the expected loss, holding uniformly, are given. These bounds are tight, as shown by a matching lower bound. Finally, a method to adaptively select both the number of rounds and the threshold is proposed for a certain class of protocols.
Comparison of reports of missed nursing care: Registered Nurses vs. practical nurses in hospitals

BACKGROUND Missed nursing care is an error of omission defined as standard, required nursing care that is not completed or is seriously delayed. Study findings from around the world show that missed nursing care is a global concern. PURPOSE The purpose of this study was to compare reports of missed nursing care by two types of nurses - registered nurses and practical nurses - in acute care hospitals in Iceland. Former studies in the USA indicate a variance in reports of missed nursing care by staff with different roles. METHODS This was a cross-sectional descriptive study using the MISSCARE Survey-Icelandic questionnaire for data collection. The questionnaire asks about the amount of missed nursing care on the unit for 24 nursing elements (Part A) and 17 reasons of care being missed (Part B). Participants were nursing staff from medical, surgical and intensive care units in all hospitals in Iceland. FINDINGS A t-test for independent groups showed a significant difference for the overall missed nursing care score (Part A) between registered nurses (M = 2.09, SD = 0.51) and practical nurses (M = 1.82, SD = 0.59) [t(541) = 5.703, p < 0.001]. A comparison of the overall mean score for reasons of missed nursing care (Part B) between registered nurses (M = 2.32, SD = 0.38) and practical nurses (M = 2.21, SD = 0.62) indicated a significant difference in their reporting [t(299) = 2.210, p = 0.028]. In spite of the overall significant difference in ratings of the elements and reasons for missed nursing care by registered nurses and practical nurses, a pattern is evident in the ranking of the elements of nursing care being missed and reasons. CONCLUSIONS The findings of this study point to the need to acknowledge certain aspects of missed nursing care and the different roles within nursing. They indicate a need to improve open, sincere and structured communication and mutual respect and trust within healthcare teams in Icelandic hospitals.
Traditional Biomolecular Structure Determination by NMR Spectroscopy Allows for Major Errors

One of the major goals of structural genomics projects is to determine the three-dimensional structure of representative members of as many different fold families as possible. Comparative modeling is expected to fill the remaining gaps by providing structural models of homologs of the experimentally determined proteins. However, for such an approach to be successful it is essential that the quality of the experimentally determined structures is adequate. In an attempt to build a homology model for the protein dynein light chain 2A (DLC2A) we found two potential templates, both experimentally determined nuclear magnetic resonance (NMR) structures originating from structural genomics efforts. Despite their high sequence identity (96%), the folds of the two structures are markedly different. This urged us to perform in-depth analyses of both structure ensembles and the deposited experimental data, the results of which clearly identify one of the two models as largely incorrect. Next, we analyzed the quality of a large set of recent NMR-derived structure ensembles originating from both structural genomics projects and individual structure determination groups. Unfortunately, a visual inspection of structures exhibiting lower quality scores than DLC2A reveals that the seriously flawed DLC2A structure is not an isolated incident. Overall, our results illustrate that the quality of NMR structures cannot be reliably evaluated using only traditional experimental input data and overall quality indicators as a reference and clearly demonstrate the urgent need for a tight integration of more sophisticated structure validation tools in NMR structure determination projects. In contrast to common methodologies where structures are typically evaluated as a whole, such tools should preferentially operate on a per-residue basis.
Local sublattice symmetry breaking for graphene with a centrosymmetric deformation

We calculate the local density of states (LDOS) for an infinite graphene sheet with a single centrosymmetric out-of-plane deformation, in order to investigate measurable strain signatures on graphene. We focus on the regime of small deformations and show that the strain-induced pseudomagnetic field induces an imbalance of the LDOS between the two triangular graphene sublattices in the region of the deformation. Real-space imaging reveals a characteristic sixfold symmetry pattern where the sublattice symmetry is broken within each fold, consistent with experimental and tight-binding observations. The open geometry we study allows us to make use of the usual continuum model of graphene and to obtain results independent of boundary conditions. We provide an analytic perturbative expression for the contrast between the LDOS of each sublattice, showing a scaling law as a function of the amplitude and width of the deformation. We confirm our results by a numerically exact iterative scattering matrix method.
Maternal perception of the onset of lactation is a valid, public health indicator of lactogenesis stage II.

Test weighing is the "gold standard" for documenting lactogenesis stage II. However, this method is impractical for use in population studies. Maternal perception of the timing of the onset of lactation may be a useful proxy for lactogenesis stage II. This study seeks to validate maternal perception of the onset of lactation as a marker of lactogenesis stage II. Women (n = 60) were recruited after cesarean delivery. Beginning at 24 h postpartum (pp), the onset of lactation was assessed 3 times daily by both test weighing and maternal perception. Delayed onset of lactation was defined as follows: 1) milk transfer < 9.2 g/feeding at 60 h pp and 2) maternal perception >/= 72 h pp. Misclassification analyses were conducted. Multivariate logistic regression, bivariate analyses and Cox survival analyses were used to evaluate the determinants and consequences of delayed onset of lactation, using both definitions. The sensitivity and specificity of delayed maternal perception as an indicator of delayed lactogenesis were 71.4 and 79.3%, respectively. Four risk factors for low milk transfer were significant (P: < 0.05) or nearly significant (P: </= 0.08) predictors of delayed perception of the onset of lactation. The effects of low milk transfer and delayed maternal perception on breast-feeding duration were similarly modified by intended breast-feeding duration. The magnitude and directionality of the ss coefficients for the milk transfer and perception variables were consistent. On the basis of these results, we conclude that maternal perception of the onset of lactation is a valid public health indicator of lactogenesis stage II.
Efficacy of Picroriza kurrooa Benth in experimentally induced hepato-toxicity in cross-bred calves.

Alcoholic extract of roots of picrorhiza kurrooa Benth was screened for its photochemical & hepato protective activity by metabolic (biochemical) profile for hepato-protective activity by invasive blood sampling in calves. The mean extractability percentage obtained was 40.5. Phytochemical study revealed that the presence of reducing sugar, glycosides & saponins. The level of SGOT (AST), SGPT (ALT), alkaline phosphates, bilirubin increased significantly while the level of protein, albumin, globulin and glucose decreased significantly and moderate but not significant increase in cholesterol level in serum in calves treated with CC14 (thrice a week for two weeks, intra ruminally) were observed. The bio-chemical alterations might be due to damage of liver cells and impairment in its functions. The animals treated with alcoholic extract 10 & 15 mg/kg Body wt. For 14 days by oral route afforded a significant protection against biochemical alterations induced by carbon tetrachloride. Thus the efficient protection of calves to varying degree, by the alcoholic extract of Picrorhiza kurrooa Benth given with carbon tetrachloride was observed from the clinical & biochemical investigations.
Development of microstructure and texture in pure shear deformed salt

Texture development in extruded rock salt has been studied by neutron diffraction. Pure shear deformation yields texture components near the ideal FCC metal copper, S, brass, Goss and cube positions. The Goss and Cube components are strengthened by dynamic and static recrystallization with cube being most stable. Comparison of the experimental textures with simulations based on different models shows that the low temperature high strain deformation texture can be qualitatively well explained by the Taylor model using slip on (110) , (100) and (111) systems with equal critical resolved shear stresses. Relaxation with increasing temperature introduces the cube and Goss component, which may represent the nuclei for recrystallization.