Miracle-dz/UniFAR-FTUs huggingface dataset:
Inventario de sexismo ambivalente: adaptación, validación y relación con variables psicosociales.

El objetivo de este estudio fue adaptar y validar para nuestra zona el Inventario de Sexismo Ambivalente ASI (Glick & Fiske, 1996). Este inventario esta constituido por 22 items distribuidos en dos dimensiones: sexismo hostil y sexismo benevolo. La muestra quedo constituida por 220 participantes de ambos sexos, todos ellos estudiantes de las carreras de psicologia, periodismo, economia e ingenieria. El ASI muestra ser confiable y valido, y nos informa de una alta correlacion con una serie de variables sociodemograficas y psicosociales. Respecto del perfil de sexismo, los hombres muestran mayores indices de sexismo tanto benevolo como hostil que las mujeres, aunque los niveles para estas –sobre todo en el de tipo benevolo- son bastante elevados. Se discuten estos resultados a la luz de las teorias sobre prejuicio y estereotipos de genero.
A Hypergraph model for clustering scale-free network

Many complex networks possess the scale-free property, which makes the task of detecting communities from these networks difficult. The application of traditional clustering algorithms on these networks has not yielded a great deal of success. In this paper we present a method of detecting community structure based on hypergraph model to address this problem. The hypergraph model maps the relationship in the original data into a hypergraph. A hyperedge represents a relationship among subsets of data and the weight of the hyperedge reflects the strength of this affinity. We assign the density of a hyperedge to its weight. We present and illustrate the results of experiments on the Enron data set. The experiments demonstrate that our approach is applicable and effective.
Granulomatous Skin Lesions in Moray Eels Caused by a Novel Mycobacterium Species Related toMycobacterium triplex

ABSTRACT An outbreak of granulomatous dermatitis was investigated in a captive population of moray eels. The affected eels had florid skin nodules concentrated around the head and trunk. Histopathological examination revealed extensive granulomatous inflammation within the dermis and subcutaneous fascial plane between the fat and axial musculature. Acid-fast rods were detected within the smallest lesions, which were presumably the ones that had developed earliest. Eventually, after several months of incubation at room temperature, a very slowly growing acid-fast organism was isolated. Sequencing of the 16S rRNA gene identified it as a Mycobacterium species closely related (0.59% divergence) to M. triplex, an SAV mycobacterium. Intradermal inoculation of healthy green moray eels with this organism reliably reproduced the lesion. Experimentally induced granulomatous dermatitis appeared within 2 weeks of inoculation and slowly but progressively expanded during the 2 months of the experiment. Live organisms were recovered from these lesions at all time points, fulfilling Koch's postulates for this bacterium. In a retrospective study of tissues collected between 1993 and 1999 from five spontaneous disease cases, acid-fast rods were consistently found within lesions, and a nested PCR for the rRNA gene also demonstrated the presence of mycobacteria within affected tissues.
Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials.

IMPORTANCE Preclinical studies have shown that neurotrophic growth factors (NTFs) extend the survival of motor neurons in amyotrophic lateral sclerosis (ALS) and that the combined delivery of these neurotrophic factors has a strong synergistic effect. We have developed a culture-based method for inducing mesenchymal stem cells (MSCs) to secrete neurotrophic factors. These MSC-NTF cells have been shown to be protective in several animal models of neurodegenerative diseases. OBJECTIVE To determine the safety and possible clinical efficacy of autologous MSC-NTF cells transplantation in patients with ALS. DESIGN, SETTING, AND PARTICIPANTS In these open-label proof-of-concept studies, patients with ALS were enrolled between June 2011 and October 2014 at the Hadassah Medical Center in Jerusalem, Israel. All patients were followed up for 3 months before transplantation and 6 months after transplantation. In the phase 1/2 part of the trial, 6 patients with early-stage ALS were injected intramuscularly (IM) and 6 patients with more advanced disease were transplanted intrathecally (IT). In the second stage, a phase 2a dose-escalating study, 14 patients with early-stage ALS received a combined IM and IT transplantation of autologous MSC-NTF cells. INTERVENTIONS Patients were administered a single dose of MSC-NTF cells. MAIN OUTCOMES AND MEASURES The primary end points of the studies were safety and tolerability of this cell therapy. Secondary end points included the effects of the treatment on various clinical parameters, such as the ALS Functional Rating Scale-Revised score and the respiratory function. RESULTS Among the 12 patients in the phase 1/2 trial and the 14 patients in the phase 2a trial aged 20 and 75 years, the treatment was found to be safe and well tolerated over the study follow-up period. Most of the adverse effects were mild and transient, not including any treatment-related serious adverse event. The rate of progression of the forced vital capacity and of the ALS Functional Rating Scale-Revised score in the IT (or IT+IM)-treated patients was reduced (from -5.1% to -1.2%/month percentage predicted forced vital capacity, P < .04 and from -1.2 to 0.6 ALS Functional Rating Scale-Revised points/month, P = .052) during the 6 months following MSC-NTF cell transplantation vs the pretreatment period. Of these patients, 13 (87%) were defined as responders to either ALS Functional Rating Scale-Revised or forced vital capacity, having at least 25% improvement at 6 months after treatment in the slope of progression. CONCLUSIONS AND RELEVANCE The results suggest that IT and IM administration of MSC-NTF cells in patients with ALS is safe and provide indications of possible clinical benefits, to be confirmed in upcoming clinical trials. TRIAL REGISTRATION clinicaltrials.gov Identifiers: NCT01051882 and NCT01777646.
Global Proteomic Analysis of Two Tick-Borne Emerging Zoonotic Agents: Anaplasma Phagocytophilum and Ehrlichia Chaffeensis

Anaplasma phagocytophilum and Ehrlichia chaffeensis are obligatory intracellular α-proteobacteria that infect human leukocytes and cause potentially fatal emerging zoonoses. In the present study, we determined global protein expression profiles of these bacteria cultured in the human promyelocytic leukemia cell line, HL-60. Mass spectrometric (MS) analyses identified a total of 1,212 A. phagocytophilum and 1,021 E. chaffeensis proteins, representing 89.3 and 92.3% of the predicted bacterial proteomes, respectively. Nearly all bacterial proteins (≥99%) with known functions were expressed, whereas only approximately 80% of “hypothetical” proteins were detected in infected human cells. Quantitative MS/MS analyses indicated that highly expressed proteins in both bacteria included chaperones, enzymes involved in biosynthesis and metabolism, and outer membrane proteins, such as A. phagocytophilum P44 and E. chaffeensis P28/OMP-1. Among 113 A. phagocytophilum p44 paralogous genes, 110 of them were expressed and 88 of them were encoded by pseudogenes. In addition, bacterial infection of HL-60 cells up-regulated the expression of human proteins involved mostly in cytoskeleton components, vesicular trafficking, cell signaling, and energy metabolism, but down-regulated some pattern recognition receptors involved in innate immunity. Our proteomics data represent a comprehensive analysis of A. phagocytophilum and E. chaffeensis proteomes, and provide a quantitative view of human host protein expression profiles regulated by bacterial infection. The availability of these proteomic data will provide new insights into biology and pathogenesis of these obligatory intracellular pathogens.
Factors of Vulnerability to Human Trafficking and Prospects for Reintegration of Former Victims. Evidence from the Philippines

Trafficking of persons is a serious and very complex issue, although too often neglected, in many developing countries, including the Philippines. We make a first attempt to produce empirical research from the angle of development economists to assess the risk factors for entering into trafficking and evaluate the prospects of reintegration of trafficked victims. We have interviewed young women resident in shelters in the Cebu area and the sample consists of girls 14 years and above living in 12 shelters in the Cebu area. We find that trafficked victims have on average lower levels of education than the non-trafficked girls. Trafficking victims are also more likely to come from larger families. 20 percent of the girls came from households where the mother was absent during the last year she lived with her family. Therefore, as expected, income appears as a main factor of vulnerability. Any policy oriented to create safety nets for families at risk, empowering women, and create better labor opportunities for girls is likely to reduce to probabilities of entering into trafficking. In terms of family dynamics, trafficking victims come from families with relatively more inter-personal conflicts. There is also more prevalence of physical violence in houses where trafficked victims lived. The violent home environment of these vulnerable girls needs to be kept in mind when designing reintegration programs. Using techniques that elicit the expectations that the girls had when leaving their household and then comparing them with what actually happened, we observe that trafficked girls underestimate the cost of leaving the household (in terms of likelihood to get pregnant, ill, use drugs) and overestimate the benefits (in terms of likelihood to marry a foreign man and being able to send back money to the family). Moreover, we also find that friends are the most prevalent mode of recruitment of trafficking while the role of formal recruiters is less important. In our sample, only 27 percent of the girls obtained their job via a recruiter. Information campaigns to explain the danger of the jobs offered could contribute to stopping the trafficking phenomenon. Finally, important insights emerged by looking at inter-temporal preferences and risk preferences of our respondents, where these preferences were elicited using the tools of experimental economics. Former victims of trafficking exhibited a relatively high degree of impatience compared to other girls. On the other hand, both groups were extremely risk averse. These results suggests that an important role should be given, when designing reintegration programs for vulnerable girls – and especially former victims of trafficking – in working on the formation of their expectation, inter-temporal preferences and risk preferences.
Tumor‐antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus

The immunohistochemical distribution and concentrations of tumor‐antigen 4 (TA‐4) in tissues and serum were determined in patients with benign and malignant diseases, including 27 patients with squamous cell carcinoma (SCC; 15 in the lung and 12 in the esophagus). Tumor‐antigen 4 immunoreactivity was present in the cytoplasm of many SCC tissues, especially in the hyperparakeratotic region, and in the cytoplasm of differentiated squamous cells of the intermediate layer of normal epithelia of various organs, but not in those of other types of lung cancers or benign pulmonary diseases. Consistent with the results of immunostaining, the TA‐4 concentrations in SCC tissues of the lung, esophagus, and normal squamous epithelia were much higher than in those of lung cancer other than SCC, benign pulmonary diseases, normal lung, and submandibular gland tissues. The TA‐4 concentration in SCC tissue tended to increase with increasing grades of differentiation. Serum TA‐4 was elevated in 15 of 27 patients with SCC but in no patients with other types of lung cancer or benign diseases. These results indicate that TA‐4 is an antigen related to the differentiation of squamous cells and that tumor cells of SCC can release a large amount of TA‐4 into circulation whereas normal squamous epithelia cannot.
Estimation of the parameters for a complex repairable system with preventive and corrective maintenance

Estimation of reliability and maintainability parameters is essential to modeling repairable systems and determining maintenance policies. However, this estimation becomes more difficult when system failure times are neither identically nor independently distributed. This is due to the aging of repairable systems under imperfect maintenance. In this paper, reliability and maintainability RAM parameters are estimated in the maximum likelihood sense based on historical RAM data and using the virtual age model of Kijima Type I and Type II. A Weibull distribution for the first system failure is assumed. Kijima Type I and II imperfect corrective and preventive maintenance are also considered. Using the maximum-likelihood approach, four parameters of this repairable system are estimated. The proposed method is illustrated with simulated data.
In Vivo and In Vitro Characterization of Mesothelial Lipid Inclusions

The nature of intracytoplasmic lipid inclusions found in cultured rabbit and rat peritoneal mesothelial cells was examined by ultrastructural and biochemical techniques. Transmission electron microscopy also demonstrated extracellular release of these lipid bodies. Differential fixation with tannic acid revealed 2 types of inclusions, lamellated (lamellar bodies) and nonlamellated (homogeneous). The lamellar bodies were found near or in the Golgi apparatus and on the cell surface where occasionally they were observed in exocytotic pouches. The homogeneous inclusions were the predominant species being found primarily intracellularly. Lipid bodies obtained from the culture media over the cells displayed on electron microscopy the same morphological characteristics as those seen intracellularly. Exposure of confluent cultures of mesothelial cells to the vital lipid stain Nile Red caused the appearance of intensely fluorescent droplets in or on the cells at wave lengths consistent with staining for phosphatidylcholine-rich vesicles. Incubation of the cells with r4C)-choline an d subsequent analysis of phospholipid formation revealed high rates of r4C)-phosphatidylcholine addition to both intra and extracellular lipid pools. Taken together, mesothelial cells exhibit lipid bodies similar in ultrastructure to the surfactant containing organelles of Type II pneumocytes.
End-to-End BER Performance of Cooperative MIMO Transmission with Antenna Selection in Rayleigh Fading

Combining a dual-hop relaying with multi-input multi-output (MIMO) transmission is a natural way to overcome the channel impairments. The antenna selection is a simple but efficient MIMO method since it enjoys the full diversity with moderate channel state information (CSI) from the receiver and no complicated spatial coding. For amplify-and-forward (AF) MIMO relaying with best antenna selection, we derive the probability density function (PDF) of the received signal-to-noise ratio (SNR) and provide a BER equation when using M-ary PSK in Rayleigh fading channels.
What can the corporate world learn from the cellarer

Purpose – Benedictine abbeys are highly stable organisations that have existed for almost 1,500 years. The extant literature ascribes this stability in part to the notion of Benedictine governance, which centres on the Rule of St Benedict (RB). An integral part of Benedictine governance is the cellarer, who plays a role comparable to that of a chief financial officer (CFO) in a traditional corporation. Unlike corporations, however, in which the CFO has emerged into a more important role over the past few decades, the cellarer has been an official position in Benedictine abbeys since the introduction of the RB in the sixth century. The present paper aims to explore the cellarer's role and assesses which parts of it could be reasonably transferred to the corporate world. Design/methodology/approach – Informed by organisational role theory, the authors conducted a single case study in an Austrian Benedictine abbey. The authors used group discussions and semi-structured interviews as the main research instrum.
The mechanism of water absorption by roots II. The role of hydrostatic pressure gradients across the cortex

Using methods described in Part I differences of pressure were applied between the external medium and the xylem elements of tomato root systems. The pressure permeability coefficient kp (the water flux per unit pressure difference), and the osmotic permeability coefficient k0 (the water flux per unit difference of osmotic potential between the external medium and the xylem elements) were compared under similar conditions of applied pressure. Also k0 was measured in the presence and absence of pressure gradients. The most striking effect of applying a pressure gradient was an increase in k0, 2 atm commonly causing a five-fold increase. Thus diffusion of water across the cortex was greatly facilitated by a pressure gradient. In addition it was found that under similar pressure conditions kp was consistently greater than k0, kp/k0 being about 1·3 with an applied pressure difference of 2 atm. This indicated a mass flow of about a quarter of the total flux under these conditions. This dual nature of the water movement was confirmed by the action of cyanide and anaerobic conditions which caused a greater reduction in k0 than kp showing that the diffusional pathway was more sensitive to decreased metabolism than the mass flow pathway. The effect of pressure gradients on diffusional water movement and the possible location of the mass flow pathway are briefly discussed as are their implications with reference to transpirational tensions and the uptake of solutes from the soil.
Adaptación española del Ahtlete Burnout Questionnaire(ABQ) para la medida del burnout en futbolistas

Spanish version of Athlete Burnout Questionnaire (ABQ) for the measurement of burnout in soccer players. The Athlete Burnout Questionnaire (ABQ) is a 15-item questionnaire that comprises three subscales: emotional/physical exhaustion, reduced sense of accomplishment, and sport devaluation. In a preliminary work, the ABQ was translated into Spanish and administered to 140 male soccer players. In the present study, we include alternative statements for weaker items. A 21-item version was administered to a sample of 326 soccer players of both sexes aged 14-23 years old. Using item and factor analyses, the questionnaire was shortened to 15 items. Then, the data was submitted to confirmatory factor analysis to corroborate the usual three-factor structure. Overall fit of the model was acceptable with a value of . 97 for CFI, . 96 for NNFI, . 93 for GFI, . 059 RMSEA, and . 061 for RMR.
Effect of Metformin on Cancer Risk and Treatment Outcome of Prostate Cancer: A Meta-Analysis of Epidemiological Observational Studies

Background Laboratory studies have shown the anti-tumor effect of metformin on prostate cancer. However, recent epidemiological studies have yielded inconclusive results. Methods We searched PubMed database from the inception to May 30 2014 for studies which assessed the effect of metformin use on cancer risk of prostate cancer, biochemical recurrence (BCR) and all-cause mortality of patients with prostate cancer. The pooled results and 95% confidence intervals (CIs) were estimated by random-effect model. Results Twenty-one studies were eligible according to the inclusion criteria. Based on the pooled results of available observational studies, metformin use was significantly associated with a decreased cancer risk (14 datasets, 963991 male subjects, odds ratio: 0.91, 95% CI: 0.85–0.97) and BCR (6 datasets, 2953 patients, hazard ratio: 0.81, 95% CI: 0.68–0.98) of prostate cancer. However, the association of metformin use with all-cause mortality of patients with prostate cancer was not significant (5 datasets, 9241 patients, hazard ratio: 0.86, 95% CI: 0.64–1.14). Conclusion Results suggest that metformin use appears to be associated with a significant reduction in the cancer risk and BCR of prostate cancer, but not in all-cause mortality of patients with prostate cancer.
The father's roles in the recovery of young Chinese suffering from anorexia nervosa in two Chinese cities, Hong Kong and Shenzhen

The fathers' role in assisting the recovery of young Chinese diagnosed with anorexia nervosa has seldom been documented in Chinese contexts, namely Hong Kong and Shenzhen. In this article the author argues for the importance of engaging the absent Chinese father in helping in this context, describing the process of family treatment and highlighting the treatment principles and skills in achieving the goal of helping, illustrating it with two clinical cases from two Chinese cities, Hong Kong and Shenzhen. Practitioner points Engaging the absent father in treatment to join hands with his spouse is crucial to assist a young Chinese person with anorexia nervosa to recover. Translation of the young person's symptoms as a developmental challenge is clinically useful to achieve the goal of paternal engagement. Increased paternal involvement to mediate mother–daughter conflicts, raising the father's self-confidence and improved marital relationships are clinically useful
Residues within the Conserved Helicase Motifs of UL9, the Origin-binding Protein of Herpes Simplex Virus-1, Are Essential for Helicase Activity but Not for Dimerization or Origin Binding Activity*

UL9, an essential gene for herpes simplex virus type 1 (HSV-1) DNA replication, exhibits helicase and origin DNA binding activities. It has been hypothesized that UL9 binds and unwinds the HSV-1 origin of replication, creating a replication bubble and promoting the assembly of the viral replication machinery; however, direct confirmation of this hypothesis has not been possible. Based on the presence of conserved helicase motifs, UL9 has been classified as a superfamily II helicase. Mutations in conserved residues of the helicase motifs I—VI of UL9 have been isolated, and most of them fail to complement a UL9 null virus in vivo (Martinez R., Shao L., and Weller S. (1992)J. Virol. 66, 6735–6746). In addition, mutants in motifs I, II, and VI were found to be transdominant (Malik, A. K., and Weller, S. K. (1996) J. Virol. 70, 7859–7866). Here we present the characterization of the biochemical properties of the UL9 helicase motif mutants. We report that mutations in motifs I–IV and VI affect the ATPase activity, and all but the motif III mutation completely abolish the helicase activity. In addition, mutations in these motifs do not interfere with UL9 dimerization or the ability of UL9 to bind the HSV-1 origin of replication. Based on the similarity of the helicase motif sequences between UL9 and UvrB, another superfamily II member with helicase-like activity, we were able to map the UL9mutations on the structure of the UvrB protein and provide an explanation for the observed phenotypes. Our results indicate that the helicase function of UL9 is indispensable for viral replication, supporting the hypothesis that UL9 is essential for unwinding the HSV-1 origin of replication in vivo. Furthermore, the data presented provide insights into the mechanism of transdominance of the UL9 helicase motif mutants.