Miracle-dz/UniFAR-FTUs huggingface dataset:
Characteristics and Outcomes of Women Veterans Undergoing Cardiac Catheterization in the Veterans Affairs Healthcare System: Insights from the VA CART Program

Background—The number of women veterans is increasing, yet little is known about their cardiovascular risk factors, coronary anatomy, cardiac treatments, and outcomes after cardiac catheterization. Prior studies have shown that nonveteran women have more risk factors, receive less aggressive treatment, and have worse outcomes, despite having less obstructive coronary artery disease than men. Whether these differences exist among women veterans in the veterans affairs healthcare system is unknown. Methods and Results—Data on 85 936 veterans (3181 women) undergoing initial cardiac catheterization between October 1, 2007, and September 30, 2012, were examined using the national veterans affairs Clinical Assessment Reporting and Tracking (CART) Program. Sex differences in demographics, indications, coronary anatomy, cardiac treatments, and outcomes were analyzed. Women veterans were younger (56.9 versus 63.0 years, P<0.0001) with fewer traditional cardiovascular risk factors, but with more obesity, depression, and posttraumatic stress disorder than men. Women had lower rates of obstructive coronary artery disease than men (22.6% versus 53.3%). Rates of procedural complications were similar in both genders. Adjusted outcomes at 1 year showed women had lower mortality (hazard ratio, 0.74; confidence interval, 0.60–0.92) and less all-cause rehospitalization (hazard ratio, 0.87; confidence interval, 0.82–0.93), but no difference in rates of unplanned percutaneous coronary intervention. Conclusions—Women veterans undergoing catheterization are younger, have more obesity, depression, and posttraumatic stress disorder, less obstructive coronary artery disease, and similar long-term outcomes, compared with men. These findings suggest a significant portion of women veterans may have chest pain not attributable to obstructive coronary artery disease. Further research into possible causes, such as endothelial dysfunction or concurrent psychological comorbidities, is needed.
Resting Metabolic Rate and Body Composition of Achondroplastic Dwarfs

Indirect calorimetry was used to measure resting metabolic rates (RMR), and densitometry and anthropometry were used to measure body fat and fat-free masses of 32 adults with very short stature. Twenty-seven of them were achondroplastic dwarfs. Their results were compared to those obtained from 103 lean and obese adults with normal heights. All 32 dwarfs had distinctly greater RMR per kg fat-free mass by densitometry than adults with average stature. However, there was a wide variation in the RMR among dwarfs, which was independent of leanness or obesity. In spite of increased RMR, obesity among dysplastic adult dwarfs was twice as prevalent as among average-height adults. Increased abdominal:hip ratios were prevalent among dwarfs, but these ratios do not reflect body fat. Body mass indices were worthless, and skinfold thicknesses and other anthropometric measurements were of very limited value in predicting the body fat of dwarfs. Although our new and specific equations for estimating RMR and body composition give reasonable values, we recommend that the caloric requirements and body compositional variables be measured if nutritional therapy is needed to induce weight loss or gain in Little People.
Efficient Exponentiation of a Primitive Root in GF(2^m)

In this paper, exponentiation of a primitive root in GF(2/sup m/) is considered. Signed digit (SD) number representation is used to efficiently represent the exponent and the corresponding algorithms and structures for exponentiation are developed. For primitive multiplications required in exponentiations, extended bidirectional linear feedback shift registers are proposed and used for the cases where the exponent is represented as a binary or a radix-4 SD number. Comparisons are made with other methods on the bases of space, time, and possible power consumption. Since the proposed structures can effectively reduce power and area when implemented in VLSI, they are especially suitable for battery powered portable devices.
Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth

Background Monocyte recruitment leads to accumulation of macrophage foam cells and contributes to atherosclerotic lesion growth. Recent studies have reported that lesion‐resident macrophages can proliferate and represent a major cellular component during lesion development. This study was designed to assess whether the rate of macrophage proliferation changes during well‐established stages of lesion growth and to characterize other populations of proliferating cells within these lesions. Methods and Results Using murine models of atherosclerosis (Apoe −/− and LDLr −/− mice) and human coronary artery lesions, in situ proliferation of lesion‐resident cells at different stages of growth was assessed by staining for Ki67 and bromodeoxyuridine (BrdU). In early lesions, close to half of all actively growing macrophages were proliferating in situ. BrdU pulse labeling allowed for accurate identification of in situ proliferating macrophages compared to those derived from monocyte recruitment. Local macrophage proliferation declined as lesions advanced. Interestingly, intimal inflammatory cell infiltrates containing proliferating T lymphocytes were identified during the active phase of lesion growth and correlated with apoptotic cell death. Inflammatory cell infiltrates were completely resolved in advanced lesions and replaced with the necrotic core. Conclusions Our findings indicate that atherosclerotic lesions contain locally proliferating macrophages primarily during early and intermediate stages of lesion growth. Furthermore, T‐lymphocyte‐enriched inflammatory cell infiltrates represent a novel subset of proliferating cells within the atherosclerotic lesion that correlate with apoptosis and precede the necrotic core. These findings have novel implications in understanding the pathogenesis of atherosclerosis and may implicate proliferating T lymphocytes as a contributing factor to lesion progression and stability.
Influence of Fragrances on Human Psychophysiological Activity: With Special Reference to Human Electroencephalographic Response

The influence of fragrances such as perfumes and room fresheners on the psychophysiological activities of humans has been known for a long time, and its significance is gradually increasing in the medicinal and cosmetic industries. A fragrance consists of volatile chemicals with a molecular weight of less than 300 Da that humans perceive through the olfactory system. In humans, about 300 active olfactory receptor genes are devoted to detecting thousands of different fragrance molecules through a large family of olfactory receptors of a diverse protein sequence. The sense of smell plays an important role in the physiological effects of mood, stress, and working capacity. Electrophysiological studies have revealed that various fragrances affected spontaneous brain activities and cognitive functions, which are measured by an electroencephalograph (EEG). The EEG is a good temporal measure of responses in the central nervous system and it provides information about the physiological state of the brain both in health and disease. The EEG power spectrum is classified into different frequency bands such as delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–13 Hz), beta (13–30 Hz) and gamma (30–50 Hz), and each band is correlated with different features of brain states. A quantitative EEG uses computer software to provide the topographic mapping of the brain activity in frontal, temporal, parietal and occipital brain regions. It is well known that decreases of alpha and beta activities and increases of delta and theta activities are associated with brain pathology and general cognitive decline. In the last few decades, many scientific studies were conducted to investigate the effect of inhalation of aroma on human brain functions. The studies have suggested a significant role for olfactory stimulation in the alteration of cognition, mood, and social behavior. This review aims to evaluate the available literature regarding the influence of fragrances on the psychophysiological activities of humans with special reference to EEG changes.
ESKIMO - energy savings using semantic knowledge of inconsequential memory occupancy for DRAM subsystem

Dynamic Random Access Memory (DRAM) is used as the bulk of the main memory in most computing systems and its energy and power consumption has become a first-class design consideration for modern systems. We propose ESKIMO, a scheme where when the program or operating systems memory manager allocates or frees up a memory region, this information is used by the architecture to optimize the working of the DRAM system, particularly to save energy and power. In this work we attempt to have the architecture work hand in hand with information about allocated and freed space provided by the program. We discuss multiple ways to use this information to reduce the energy and power consumption of the memory and present results of this optimization. We evaluate the energy and power benefits of our technique using a publicly available, hardware-validated, DRAM simulator, DRAMsim [1]. Our current studies show very promising results with energy savings on average of 39%.
A high resolution spectral atlas of brown dwarfs

ABSTRACT We present a UVES/VLT high resolution atlas of three L dwarfs and one T dwarf system, spectral classes at which most of theobjects are brown dwarfs. Our atlas covers the optical region from H up to the near infrared at 1m. We present spectral details ofultra-cool atmospheres at very high resolution (R ˘33000) and compare the spectra to model calculations. Our comparison showsthat molecular features from VO and CaH, and atomic features from Cs and Rb are reasonably well ﬁt by current models. On theother hand, features due to TiO, CrH, and water, and atomic Na and K reveal large discrepancies between model calculations and ourobservations. Key words. Line: identiﬁcation – Stars: low-mass, brown dwarfs – Stars: atmospheres 1. Introduction The analysis of brown dwarfs has seen tremendous progresssince their ﬁrst detection more than ten years ago. Since then,the stellar spectral sequence was augmented by spectral classesL and T at its cool end. L and T objects must certainly be coolerthan those classiﬁed as spectral type M, but the reasons for thespectral evolution through the L- and T-classes turned out to bemore complex than in the hotter objects (see e.g., Kirkpatrick2005). The formation of molecules sets in at temperatures typ-ical for spectral classes K and M, and their opacities begin tocause strong deviations from blackbody spectra. Furthermore,the condensation of dust clouds becomes important at the transi-tion from M to L and dominates the appearance of spectral classL objects. At the L to T transition, the atmospheric e ects of thedust grains weaken, but this transition is still poorly understood(Burrows et al. 2006). Objects of spectral class T are always brown dwarfs accord-ing to standard evolutionary models (Chabrier & Bara e 2000). Depending on age, however, objects of spectral classes M or Lmay be either brown dwarfs or hydrogen-burning stars. Youngbrown dwarfs can be found in the same temperature range asold low-mass stars, hence it is not possible to determine browndwarf status from the spectral type (taken as proxy for e ectivetemperature) alone (Basri 2000; Chabrier et al. 2005). As brown dwarfs are deﬁned by mass, there is no obviousatmospheric feature that determines brown dwarf status by justlooking at an object’s spectrum. While the Li-test (e.g., Basri2000) is a useful tool in young objects, it is not suitable for themajority of old (ﬁeld) objects. Age can as well be determined in
The underestimated role of temperature–oxygen relationship in large‐scale studies on size‐to‐temperature response

Abstract The observation that ectotherm size decreases with increasing temperature (temperature‐size rule; TSR) has been widely supported. This phenomenon intrigues researchers because neither its adaptive role nor the conditions under which it is realized are well defined. In light of recent theoretical and empirical studies, oxygen availability is an important candidate for understanding the adaptive role behind TSR. However, this hypothesis is still undervalued in TSR studies at the geographical level. We reanalyzed previously published data about the TSR pattern in diatoms sampled from Icelandic geothermal streams, which concluded that diatoms were an exception to the TSR. Our goal was to incorporate oxygen as a factor in the analysis and to examine whether this approach would change the results. Specifically, we expected that the strength of size response to cold temperatures would be different than the strength of response to hot temperatures, where the oxygen limitation is strongest. By conducting a regression analysis for size response at the community level, we found that diatoms from cold, well‐oxygenated streams showed no size‐to‐temperature response, those from intermediate temperature and oxygen conditions showed reverse TSR, and diatoms from warm, poorly oxygenated streams showed significant TSR. We also distinguished the roles of oxygen and nutrition in TSR. Oxygen is a driving factor, while nutrition is an important factor that should be controlled for. Our results show that if the geographical or global patterns of TSR are to be understood, oxygen should be included in the studies. This argument is important especially for predicting the size response of ectotherms facing climate warming.
The effect of platelet-rich plasma on posterolateral lumbar fusion in a rat model.

BACKGROUND Our purpose was to examine platelet-rich plasma (PRP) for its effect on bone formation and to follow the immunohistochemical changes in calcitonin gene-related peptide (CGRP) in dorsal root ganglion neurons innervating the discs as a possible index of nociceptive nerve transmission in a rat model. METHODS A total of seventy rats were used. Ten constituted a non-punctured disc sham group, while another ten rats constituted a group that underwent puncture of the L4-L5 discs. Forty rats were in experimental groups in which the L4-L5 discs were punctured; posterolateral lumbar arthrodesis was performed with PRP (the PRP group) or without the use of PRP (the normal arthrodesis group), with twenty rats in each group. The remaining ten rats were used as blood donors. Four and eight weeks after surgery, microcomputed tomography examinations were done to evaluate the amount of bone and the L4-L5 spines were harvested to evaluate bone union, followed by resection of dorsal root ganglion neurons. The percentages of Fluoro-Gold-labeled and CGRP-immunoreactive neurons were calculated. RESULTS The platelet count and the concentration of growth factors in PRP were higher than those in blood (p < 0.05). The bone volumes observed in the PRP group were significantly greater than those of the normal arthrodesis group at four and eight weeks (p < 0.05). Three (30%; 95% confidence interval [CI], 6% to 65%) of ten rats in the normal arthrodesis group and eight (80%; 95% CI, 44% to 98%) of ten rats in the PRP group were considered to have bone fusion four weeks after surgery (p < 0.05). At eight weeks, seven (70%; 95% CI, 34% to 94%) of ten rats in the normal arthrodesis group and nine (90%; 95% CI, 55% to 99%) of ten rats in the PRP group were considered to have bone fusion (p = 0.27). The proportion of CGRP-immunoreactive neurons was significantly greater in the punctured group than in the other groups. There were no significant differences between the normal arthrodesis group and the PRP group. CONCLUSIONS PRP appears to promote bone formation in rats and has a tendency to shorten the period of bone union in this rat model of posterolateral lumbar arthrodesis, but it did not influence the proportion of CGRP-immunoreactive neurons, a likely indicator of inflammatory pain originating from the degenerative intervertebral disc. CLINICAL RELEVANCE The ability of PRP in this model suggests that it may be able to shorten the period of union and lead to an early return to social activities after treatment.
DNA barcoding in surveys of small mammal communities: a field study in Suriname

The performance of DNA barcoding as a tool for fast taxonomic verification in ecological assessment projects of small mammals was evaluated during a collecting trip to a lowland tropical rainforest site in Suriname. We also compared the performance of tissue sampling onto FTA CloneSaver cards vs. liquid nitrogen preservation. DNA barcodes from CloneSaver cards were recovered from 85% of specimens, but DNA degradation was apparent, because only 36% of sequence reads were long (over 600 bp). In contrast, cryopreserved tissue delivered 99% barcode recovery (97% > 600 bp). High humidity, oversampling or tissue type may explain the poor performance of CloneSaver cards. Comparison of taxonomic assignments made in the field and from barcode results revealed inconsistencies in just 3.4% of cases and most of the discrepancies were due to field misidentifications (3%) rather than sampling/analytical error (0.5%). This result reinforces the utility of DNA barcoding as a tool for verification of taxonomic identifications in ecological surveys, which is especially important when the collection of voucher specimens is not possible.
Association between angiotensin converting enzyme gene polymorphism and coronary artery disease in individuals of the South-Eastern Anatolian population.

OBJECTIVE The deletion (D) allele of the angiotensin-converting enzyme (ACE) gene has been proposed as a genetic marker of the risk of coronary artery disease (CAD). In this study we aimed to determine the relevance of ACE gene polymorphism for coronary artery disease in the South-Eastern Anatolian population. METHODS Angiotensin converting enzyme genotypes were determined in 133 CAD patients who underwent coronary angiography. Severity of CAD was subgrouped according to the number of stenotic vessels on coronary angiography. The control group was selected from 154 healthy volunteers. Angiotensin converting enzyme genotypes were determined by agarose gel sizing after polymerase chain reaction (PCR) amplification. RESULTS Frequency of ACE DD genotype did not differ between patients with CAD and control subjects. However the ACE II genotype in CAD group was significantly less frequent than in control group (p=0.02). The relative risks were 0.9 (95% CI=0.56-1.43) for the DD genotypes, and 2.2 (95% CI=1.09 - 4.11) for the II genotype. In the 2-vessel CAD subgroups, the II genotypes were significantly different from control group. CONCLUSION Our study did not confirm the possibility that the ACE DD genotypes may be associated with predisposition to CAD in this certain population but there is a relationship between the least frequencies of the II genotype and CAD. The II genotype seems to be an independent protective factor for CAD in the South-Eastern Anatolian population.
Long non-coding RNAs in Colorectal Cancer: Progression and Future Directions

Identification of the colorectal adenoma-carcinoma sequence with its corresponding genetic and epigenetic alterations has significantly increased our knowledge of the etiopathogenesis of colorectal cancer (CRC). However, the molecular mechanisms of colorectal carcinogenesis and metastasis haven't been clearly elucidated. Long non-coding ribonucleic acids (lncRNAs) are key participants of gene regulations rather than “noises”. Accumulative studies have implicated that the aberrant expressions of lncRNAs are tightly corelated to CRC screening, diagnosis, prognosis and therapeutic outcomes. Our review focuses on recent findings on the involvement of lncRNAs in CRC oncogenesis and the lncRNA-based clinical implications in patients with CRC.
Identification of Deep Levels Associated with Extended and Point Defects in GeSn Epitaxial Layers using DLTS

Deep levels associated with extended and point defects in MOS capacitors fabricated on unintentionally doped GeSn epitaxial layers on Ge-on-Si substrates have been studied by Deep Level Transient Spectroscopy (DLTS). A 9nm layer of Al2O3 is deposited as high-k gate dielectric by Molecular Beam Epitaxy. The trap kinetics and origin of defect states is discussed. Also, it is shown that the dislocation cores in relaxed p-Ge are associated with bandlike donor-like states in the lower half of the band gap, and act as carrier trapping and recombination centers. In addition, slow and fast oxide interface traps are observed.
A preliminary evaluation of the hardware acceleration of the cray gemini interconnect for PGAS languages and comparison with MPI

The Gemini interconnect on the Cray XE6 platform provides for lightweight remote direct memory access (RDMA) between nodes, which is useful for implementing partitioned global address space languages like UPC and Co-Array Fortran. In this paper, we perform a study of Gemini performance using a set of communication microbenchmarks and compare the performance of one-sided communication in PGAS languages with two-sided MPI. Our results demonstrate the performance benefits of the PGAS model on Gemini hardware, showing in what circumstances and by how much one-sided communication outperforms two-sided in terms of messaging rate, aggregate bandwidth, and computation and communication overlap capability. For example, for 8-byte and 2KB messages the one-sided messaging rate is 5 and 10 times greater respectively than the two-sided one. The study also reveals important information about how to optimize one-sided Gemini communication.
Recovering Traceability Links between Code and Documentation

Software system documentation is almost always expressed informally in natural language and free text. Examples include requirement specifications, design documents, manual pages, system development journals, error logs, and related maintenance reports. We propose a method based on information retrieval to recover traceability links between source code and free text documents. A premise of our work is that programmers use meaningful names for program items, such as functions, variables, types, classes, and methods. We believe that the application-domain knowledge that programmers process when writing the code is often captured by the mnemonics for identifiers; therefore, the analysis of these mnemonics can help to associate high-level concepts with program concepts and vice-versa. We apply both a probabilistic and a vector space information retrieval model in two case studies to trace C++ source code onto manual pages and Java code to functional requirements. We compare the results of applying the two models, discuss the benefits and limitations, and describe directions for improvements.
Speech analysis of sung-speech and lyric recognition in monophonic singing

Lyric recognition in singing is challenging because of a number of problems, including a lack of singing databases, superposed musical instruments and different spectral variations. First of all, we investigated the difference of spectral variations among read speech, spontaneous speech and sung speech and we found that sung speech recognition was the most difficult. Next, we consider Japanese lyric recognition in monophonic singing that contains no musical instruments. To express singing well, we use an n-gram language model with a lyrics corpus, singing-adapted acoustic models, and plural pronunciation lexicons for vowel-lengthening. We also compare GMM-HMM and DNN-HMM acoustic models. We obtained a remarkable improvement on lyric recognition in comparison with the baseline system for spontaneous speech recognition.