Miracle-dz/UniFAR-FTUs huggingface dataset:
Hydroclimate of the Last Glacial Maximum and deglaciation in southern Australia's arid margin interpreted from speleothem records (23–15 ka)

Abstract. Terrestrial data spanning the Last Glacial Maximum (LGM) and deglaciation from the southern Australian region are sparse and limited to discontinuous sedimentological and geomorphological records with relatively large chronological uncertainties. This dearth of records has hindered a critical assessment of the role of the Southern Hemisphere mid-latitude westerly winds on the region's climate during this time period. In this study, two precisely dated speleothem records for Mairs Cave, Flinders Ranges, are presented, providing for the first time a detailed terrestrial hydroclimatic record for the southern Australian drylands during 23–15 ka. Recharge to Mairs Cave is interpreted from the speleothem record by the activation of growth, physical flood layering, and δ18O and δ13C minima. Periods of lowered recharge are indicated by 18O and 13C enrichment, primarily affecting δ18O, argued to be driven by evaporation of shallow soil/epikarst water in this water-limited environment. A hydrological driver is supported by calcite fabric changes. These include the presence of laminae, visible organic colloids, and occasional dissolution features, related to recharge, as well as the presence of sediment bands representing cave floor flooding. A shift to slower-growing, more compact calcite and an absence of lamination is interpreted to represent reduced recharge. The Mairs Cave record indicates that the Flinders Ranges were relatively wet during the LGM and early deglaciation, particularly over the interval 18.9–15.8 ka. This wetter phase ended abruptly with a shift to drier conditions at 15.8 ka. These findings are in agreement with the geomorphic archives for this region, as well as the timing of events in records from the broader Australasian region. The recharge phases identified in the Mairs Cave record are correlated with, but antiphase to, the position of the westerly winds interpreted from marine core MD03-2611, located 550 km south of Mairs Cave in the Murray Canyons region. The implication is that the mid-latitude westerlies are located further south during the period of enhanced recharge in the Mairs Cave record (18.9–16 ka) and conversely are located further north when greater aridity is interpreted in the speleothem record. A further comparison with speleothem records from the northern Australasian region reveals that the availability of tropical moisture is the most likely explanation driving enhanced recharge, with further amplification of recharge occurring during the early half of Heinrich Stadial 1 (HS1), possibly influenced by a more southerly displaced Intertropical Convergence Zone (ITCZ). A rapid transition to aridity at 15.8 ka is consistent with a retraction of this tropical moisture source.
Adeno-associated virus encoding green fluorescent protein as a label for retinal pigment epithelium.

PURPOSE To determine whether transduction with adeno-associated virus encoding green fluorescent protein (AAV-GFP) is useful for labeling transplanted retinal pigment epithelial cells (RPE). METHODS Transduction was performed by infection of confluent or subconfluent cultured feline RPE or by subretinal injection. Cells transduced in vitro were analyzed to determine label stability over time and label conservation with cell division. RPE transduced in vivo were harvested at 5 weeks for transplantation or immunohistochemical detection. Two cats received subretinal injections of harvested cells and were killed at 3 or 7 days. RESULTS In vitro transduction of confluent RPE resulted in stable GFP fluorescence for at least 3 months. There was a marked decline in fluorescence after cell division. Nonconfluent transduced cells conserved label after cell division but showed a marked decline in the number of cells, due to cell death. In vivo transduction resulted in a high level of labeling, allowing labeled cells to be harvested and transplanted. Transplanted cells were detected immunohistochemically. Photoreceptor labeling was detected over areas containing a high density of transplanted, labeled RPE derived from cells transduced in vivo. Possible light toxicity to transduced RPE was observed. CONCLUSIONS AAV-GFP-labeling of confluent cultured RPE and RPE in situ can be used to identify transplanted RPE, with some reservations. Cell division may cause dilution of the label, and release of cell contents into the subretinal space may cause label transfer to photoreceptors. Exposure to light of transduced cells should be limited.
Electoral rules, forms of government, and political budget cycles in transition countries

Recent studies have suggested the existence of election-year economics in fiscal policy in transition countries. This study asks whether such electoral cycles in aggregate measures (overall expenditures, revenues and balance) and spending composition (broad vs. targeted outlays) differ among countries with different political systems. This question is motivated by a sharp division between majoritarianpresidential systems in Central Asia and Eastern Europe, and proportional-parliamentary systems in the Baltics, Central and Southeastern Europe. Further, in the absence of context-sensitive theories, the paper asks whether observed outcomes in the transition process conform to the theoretical priors developed for conditions in stable democracies. Finally, the paper attempts to normatively establish whether either of the alternative combinations yields more optimal policy outcomes. The results suggest that the differences indeed exist, primarily on the revenue side and in the composition of expenditures. These results differ markedly from those for stable democracies, especially in the case of composition of spending. Normatively, presidentialism yields suboptimal outcomes in comparison to parliamentarianism, likely due to inefficient system of constitutionally intended checks and balances.
Wheat Transcription Factor TaAREB3 Participates in Drought and Freezing Tolerances in Arabidopsis

AREB (ABA response element binding) proteins in plants play direct regulatory roles in response to multiple stresses, but their functions in wheat (Triticum aestivum L.) are not clear. In the present study, TaAREB3, a new member of the AREB transcription factor family, was isolated from wheat. Sequence analysis showed that the TaAREB3 protein is composed of three parts, a conserved N-terminal, a variable M region, and a conserved C-terminal with a bZIP domain. It belongs to the group A subfamily of bZIP transcription factors. TaAREB3 was constitutively expressed in stems, leaves, florets, anthers, pistils, seeds, and most highly, in roots. TaAREB3 gene expression was induced with abscisic acid (ABA) and low temperature stress, and its protein was localized in the nucleus when transiently expressed in tobacco epidermal cells and stably expressed in transgenic Arabidopsis. TaAREB3 protein has transcriptional activation activity, and can bind to the ABRE cis-element in vitro. Overexpression of TaAREB3 in Arabidopsis not only enhanced ABA sensitivity, but also strengthened drought and freezing tolerances. TaAREB3 also activated RD29A, RD29B, COR15A, and COR47 by binding to their promoter regions in transgenic Arabidopsis. These results demonstrated that TaAREB3 plays an important role in drought and freezing tolerances in Arabidopsis.
Entropy rigidity of Hilbert and Riemannian metrics

In this paper we provide two new characterizations of real hyperbolic $n$-space using the Poincare exponent of a discrete group and the volume growth entropy. The first characterization is in the space of Hilbert metrics and generalizes a result of Crampon. The second is in the space of Riemannian metrics with Ricci curvature bounded below and generalizes a result of Ledrappier and Wang.
Using a Multi-Trait Approach to Manipulate Plant Functional Diversity in a Biodiversity-Ecosystem Function Experiment

A frequent pattern emerging from biodiversity-ecosystem function studies is that functional group richness enhances ecosystem functions such as primary productivity. However, the manipulation of functional group richness goes along with major disadvantages like the transformation of functional trait data into categories or the exclusion of functional differences between organisms in the same group. In a mesocosm study we manipulated plant functional diversity based on the multi-trait Functional Diversity (FD)-approach of Petchey and Gaston by using database data of seven functional traits and information on the origin of the species in terms of being native or exotic. Along a gradient ranging from low to high FD we planted 40 randomly selected eight-species mixtures under controlled conditions. We found a significant positive linear correlation of FD with aboveground productivity and a negative correlation with invasibility of the plant communities. Based on community-weighted mean calculations for each functional trait, we figured out that the traits N-fixation and species origin, i.e. being native or exotic, played the most important role for community productivity. Our results suggest that the identification of the impact of functional trait diversity and the relative contributions of relevant traits is essential for a mechanistic understanding of the role of biodiversity for ecosystem functions such as aboveground biomass production and resistance against invasion.
On explicit algebraic stress models for complex turbulent flows

Explicit algebraic stress models that are valid for three-dimensional turbulent flows in non-inertial frames are systematically derived from a hierarchy of second-order closure models. This represents a generalization of the model derived by Pope (1975) who based his analysis on the Launder, Reece & Rodi model restricted to two-dimensional turbulent flows in an inertial frame. The relationship between the new models and traditional algebraic stress models – as well as anisotropic eddy viscosity models – is theoretically established. A need for regularization is demonstrated in an effort to explain why traditional algebraic stress models have failed in complex flows. It is also shown that these explicit algebraic stress models can shed new light on what second-order closure models predict for the equilibrium states of homogeneous turbulent flows and can serve as a useful alternative in practical computations.
Pregnancy status and fetal prion genetics determine PrPSc accumulation in placentomes of scrapie-infected sheep

Ovine scrapie is a fatal neurodegenerative disorder that may be transmitted through exposure to infected uterine and placental tissues. Susceptibility to scrapie is primarily controlled by polymorphisms in the prion protein (PrP) gene. Scrapie in the U.S. Suffolk breed and in many breeds in Europe occurs in sheep homozygous for glutamine (171QQ), but rarely in sheep heterozygous for glutamine and arginine (171QR) or homozygous for arginine (171RR) at codon 171 of the PrP gene. This study demonstrated that accumulation of PrPSc in uterine-placental epithelial cells in the placentome was determined by fetal PrP genotype and the pregnancy status of scrapie-infected ewes. PrPSc was detected in 171QQ placentomes of infected ewes, but not in placentomes of infected ewes pregnant with 171QR conceptuses or in the non-pregnant uterus of infected ewes. The distribution of PrPSc plaques in placentomes was temporally associated with stage of gestation. There was a tendency toward increased size and number of placentomal PrPSc plaques from the endometrial stalk (maternal side) to chorionic plate (fetal side). These results indicate that accumulation of PrPSc is eliminated or reduced to undetectable levels in reproductive and placental tissues if infected ewes are not pregnant or conceive conceptuses with a resistant PrP genotype.
The role of thrombin in proliferative vitreoretinopathy.

PURPOSE To determine the role of thrombin in the development of proliferative vitreoretinopathy (PVR). METHODS Vitreous was collected from patients undergoing a vitrectomy (macular holes and puckers, n = 11 [controls]; retinal detachment without PVR development following vitrectomy, n = 15 [RRD1]; retinal detachment with PVR development within 6 months after vitrectomy, n = 11 [RRD2]; and established PVR, n = 14 [PVR]). Thrombin activity in vitreous was determined using a thrombin-specific chromogenic substrate. ARPE-19 cells were stimulated with 8× diluted vitreous samples in the presence and absence of hirudin. The samples were analyzed at t = 0 and t = 24 hours for the presence of 27 cytokines/chemokines and growth factors using a multiplex approach. In comparable studies, ARPE-19 cells were stimulated for 2 hours, and mRNA expression levels for CCL2, CXCL8, GMCSF, IL6, and PDGFB were determined by real-time quantitative (RQ)-PCR. RESULTS Thrombin activity was significantly (P < 0.05) higher in vitreous of the PVR group compared to the other groups. Proliferative vitreoretinopathy vitreous stimulated the production of chemokine (C-C motif) ligand (CCL)2, chemokine (C-X-C motif) ligand (CXCL)8, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, and platelet-derived growth factor (PDGF)-BB by ARPE-19 to significantly (P < 0.05) higher levels than vitreous from the RRD1 and RRD2 groups. These effects of PVR vitreous were significantly (P < 0.05) reduced by hirudin. These data were confirmed by mRNA studies. CONCLUSIONS Thrombin activity is increased in vitreous of patients with established PVR and is involved in the activation of proinflammatory and profibrotic pathways in RPE cells. Inhibition of thrombin activity may therefore represent a potential treatment option for proliferative vitreoretinopathy.
Towards Measuring the Agility of Software Business

Agile development methods have been employed across the software industry. However, it is not always clear if the used methods actually help the software firms in being more agile and if agility has a positive influence in the software firm performance. Studying these questions may turn out impossible since good measurements for assessing the overall agility of software firms do not yet exist. A need is therefore detected to measure the differences in agility between firms and finding the means to evaluate the differences in agility in reliable manner. This article examines how to measure the agility of a software firm and reports initial steps in the process of developing measurement instruments. The measurement instrument is tested against data collected from Finnish software firms and purified for further analyses.
MAPPINGS IN STRICTLY CONVEX BANACH SPACES

In this paper, we present some common fixed point results for a commuting pair of mappings, including a quasi-nonexpansive single valued mapping and a generalized nonexpansive multivalued mapping in strictly convex Banach spaces, as well as for a pointwise asymptotically nonexpansive mapping and a generalized nonexpansive multivalued mapping in uniformly convex Banach spaces. The results we obtain extend and improve some known results due to Garcia-Falset et al. (2011), Kirk and Massa (1990), Espinola et al. (2011), Kaewcharoen and Panyanak (2011) as well as that of Abkar and Eslamian (2010).
Nondestructive Determination of Soluble Solids in Tomatoes using Near Infrared Spectroscopy

A nondestructive optical method for determining the soluble solids content of fresh whole tomatoes was investigated. The method, based upon near infrared spectrophotometric techniques, could predict the soluble solids content of tomatoes (r 5 0.92, SEC 5 0.277Brix). Tomatoes from more than 30 popular fresh market cultivars at stages of maturity from mature green to ripe red fruit were studied.
Influence of intraoperative course on visual outcome after an RPE-choroid translocation.

PURPOSE In a previous study, preoperative variables were correlated with postoperative visual outcome after the translocation of a free RPE-choroid graft. The present study was conducted to investigate whether the intraoperative course was an independent factor influencing visual outcome in these patients. METHODS This was a prospective interventional case series of 48 patients with exudative AMD treated with an RPE-choroid translocation. Preoperative and postoperative evaluation included ETDRS visual acuity (VA) and fixation testing by a masked examiner. Four critical surgical steps were evaluated, and the intraoperative course was graded from 0 (uncomplicated surgery) to 5 (most complicated surgery). The relationship between intraoperative course adjusted for preoperative delay/lesion composition and visual outcome at 3 months and 1 year after surgery was analyzed with multivariate analysis. RESULTS The mean VA (logMAR) improved slightly from 0.99 before surgery to 1.00, 0.94, 0.89, and 0.91 after 3, 6, 9, and 12 months, respectively. Foveal fixation on the graft was present in 34 (71%) of the eyes at 1 year after surgery. The intraoperative course was statistically significantly associated with the DeltaVA (logMAR) at 3 months (P = 0.037) and at 1 year after surgery (P = 0.020) and if measured as gain or loss of > or =2 ETDRS-lines (odds ratio [OR] 1.8, 95% confidence interval [CI] 1.7 to 2.8, P = 0.027) and > or =3 ETDRS lines (OR, 2.2, 95% CI 1.9-3.5, P = 0.003); better surgery was associated with visual gain whereas eventful surgery was associated with visual loss. CONCLUSIONS The intraoperative course adjusted for preoperative variables had a statistically significant influence on postoperative visual outcomes in patients treated with a free RPE-choroid translocation. Refining the surgery could improve results.
On a novel solid lubricant technique: A study on the tribological characteristics under dry slide condition

The purpose of this study is to investigate the friction and wear behavior of novel electrostatic micro-solid lubricant (EMSL) bonded molybdenum disulfide (MoS2) coatings on cemented carbide tools under dry slide condition. Pin-on-disc tribological tests between titanium alloy Ti–6Al–4 V and uncoated/coated cemented tungsten carbide–cobalt alloy (WC–Co) were carried out over a range of experimental domain of sliding speeds and normal loads. Specimen wear rate and friction coefficient were investigated. Tribological tests demonstrate that EMSL bonded MoS2 coatings provide excellent anti-friction and reasonable wear performances. The mechanism of enhanced friction and wear behavior with the MoS2 coatings is discussed. This study explores the feasibility of using EMSL coatings onto tribological components and opens a new way to implement bonded MoS2 solid lubricant coatings as a new candidate for tribological operations.
New Developments in Vision Research Selected Antimicrobial Activity of Topical Ophthalmic Anesthetics

Margaret M. Reynolds, Kerryl E. Greenwood-Quaintance, Robin Patel, and Jose S. Pulido 1 Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA 2 Department of Laboratory Medicine, Mayo Clinic, Rochester, MN, USA 3 Department of Infectious Disease, Mayo Clinic, Rochester, MN, USA 4 Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA 5 VRS Foundation Board Member, Mayo Clinic, Rochester, MN, USA
A loop-counting method for covariate-corrected low-rank biclustering of gene-expression and genome-wide association study data

A common goal in data-analysis is to sift through a large data-matrix and detect any significant submatrices (i.e., biclusters) that have a low numerical rank. We present a simple algorithm for tackling this biclustering problem. Our algorithm accumulates information about 2-by-2 submatrices (i.e., ‘loops’) within the data-matrix, and focuses on rows and columns of the data-matrix that participate in an abundance of low-rank loops. We demonstrate, through analysis and numerical-experiments, that this loop-counting method performs well in a variety of scenarios, outperforming simple spectral methods in many situations of interest. Another important feature of our method is that it can easily be modified to account for aspects of experimental design which commonly arise in practice. For example, our algorithm can be modified to correct for controls, categorical- and continuous-covariates, as well as sparsity within the data. We demonstrate these practical features with two examples; the first drawn from gene-expression analysis and the second drawn from a much larger genome-wide-association-study (GWAS).
Environmental Exposure and Genetic Predisposition as Risk Factors for Asthma in China

Asthma is the most common chronic pulmonary disease worldwide and places a considerable economic burden on society. China is the world's largest developing country and has the largest population. China has undergone dramatic changes in the past few decades. The traditional lifestyle and living environment have changed in ways that directly affect the prevalence of asthma. The prevalence of asthma is lower in Chinese children and adults than in developed countries, but the prevalence has been on the rise during the past 30 years. The prevalence significantly varies among different parts of China. Polymorphisms of multiple genes, outdoor air pollution caused by PM2.5, PM10, SO2, NO2, environmental tobacco smoke, and coal, indoor pollution, and inhaled allergens, such as house dust mites, pollen, and cockroach particles, are risk factors for asthma.
Effect of oseltamivir treatment on anticoagulation: a cross-over study in warfarinized patients.

AIM To investigate whether oseltamivir enhances the anticoagulant effect of warfarin and to evaluate any pharmacokinetic (PK) interaction between the agents. METHODS Twenty volunteers (mean age 62 years) receiving daily warfarin and with INR values of 2.0-3.5 during the previous 2 weeks were randomized to concomitant oseltamivir 75 mg twice daily for 4.5 days or warfarin alone in a two-way cross-over design with a 4-8 day wash-out. Anticoagulant effects were assessed by calculating overall [AUEC(0,96 h)] and observed maximum effect (E(max) ) increase from baseline in INR, decrease from baseline in factor VIIa, and change in vitamin K₁ concentrations. Plasma pharmacokinetics of (R)- and (S)-warfarin and oseltamivir were also assessed. RESULTS For both treatments, changes in INR and factor VIIa during treatment were small; for net AUEC(0,96 h), least square mean values were -9.53 (oseltamivir + warfarin) and -1.69 h (warfarin alone) for INR (difference -7.84 h, 90% CI -18.86, 3.17 h), and 1.56 and 0.54 kIU l⁻¹ h, respectively, for factor VIIa (difference, 1.01 kIU l⁻¹ h; 90% CI -1.18, 3.21). Differences between the treatments in E(max) increase from baseline for INR, decrease from baseline for factor VIIa and change from baseline in vitamin K₁ concentration were not statistically significant. Oseltamivir did not alter warfarin pharmacokinetics. Oseltamivir was well tolerated in this study with no clinically significant adverse safety findings. CONCLUSION Concomitant administration of oseltamivir for 4.5 days to volunteers on daily warfarin had little or no effect on warfarin pharmacokinetics and no effect on pharmacodynamics.