Miracle-dz/UniFAR-FTUs huggingface dataset:
The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control

The fission yeast mutant dis3-54 is defective in mitosis and fails in chromosome disjunction. Its phenotype is similar to that of dis2-11, a mutant with a mutation in the type 1 protein phosphatase gene. We cloned the dis3+ gene by transformation. Nucleotide sequencing predicts a coding region of 970 amino acids interrupted by a 164-bp intron at the 65th codon. The predicted dis3+ protein shares a weak but significant similarity with the budding yeast SSD1 or SRK1 gene product, the gene for which is a suppressor for the absence of a protein phosphatase SIT4 gene or the BCY1 regulatory subunit of cyclic AMP-dependent protein kinase. Anti-dis3 antibodies recognized the 110-kDa dis3+ gene product, which is part of a 250- to 350-kDa oligomer and is enriched in the nucleus. The cellular localization of the dis3+ protein is reminiscent of that of the dis2+ protein, but these two proteins do not form a complex. A type 1 protein phosphatase activity in the dis3-54 mutant extracts is apparently not affected. The dis3+ gene is essential for growth; gene disruptant cells do not germinate and fail in cell division. Increased dis3+ gene dosage reverses the Ts+ phenotype of a cdc25 wee1 strain, as does increased type 1 protein phosphatase gene dosage. Double mutant dis3 dis2 is lethal even at the permissive temperature, suggesting that the dis2+ and dis3+ genes may be functionally overlapped. The role of the dis3+ gene product in mitosis is unknown, but this gene product may be directly or indirectly involved in the regulation of mitosis.
Poverty and inequality in the UK: 2007

This Briefing Note provides an update on trends in living standards, income inequality and poverty. It uses the same approach to measuring income and poverty as the government employs in its Households Below Average Income (HBAI) publication. The analysis is based on the latest HBAI figures (published on 27 March 2007), providing information about incomes up to the year 2005-06. The measure of income used is net household weekly income, which has been adjusted to take account of family size ('equivalised'). The income amounts provided below are expressed as the equivalent for a couple with no children, and all changes given are in real terms (i.e. after adjusting for inflation). For the first time in recent years, data are available for the whole of the United Kingdom, not just Great Britain, but data for Northern Ireland are only available from 2002-03. Some comparisons over time are provided for Great Britain only, but others will compare statistics for GB before 2002-03 with those for the UK afterwards. PLEASE NOTE: On 23 April 2007, the Department for Work and Pensions announced that an error had occurred when producing the latest Households Below Average Income publication. This Briefing Note was based on the same dataset and therefore suffers from similar errors. In response to revisions announced by the DWP in May 2007, we have now updated our findings in a revised press release and have produced a revised summary.
Forecasting Exchange Rates of Major Currencies with Long Maturity Forward Rates

This paper shows that error correction models assuming that long-maturity forward rates are stationary outperform the random walk in out of sample forecasting at forecasting horizons mostly above one year, for US dollar exchange rates against nine industrial countries’ currencies, using the 1990-2006 period for evaluating the out of sample forecasts. The improvement in forecast accuracy of our models is economically significant for most of the exchange rate series, and statistically significant according to a bootstrap test. Our results are robust to the specification of the error correction model and to the underlying data frequency.
[Influences of genetic and environmental factors on smoking related behaviors among male twin adults in China].

OBJECTIVE To analyze the influences of genetic and environmental factors on smoking behavior, smoking cessation and onset age of smoking less than 20 years in male twin adults. METHODS A face-to-face questionnaire was conducted to collect data from 6 458 pair male twins aged ≥25 years registered in 9 provinces(municipality)in China. The heritability of three smoking related behaviors were calculated by using structural equation models. RESULTS The ACE models were the best models of the three dimensions of smoking, i.e. smoking behavior, smoking cessation and onset age of smoking less than 20 years for male twins, and the corresponding heritability of these behaviors were 0.26(0.19-0.34), 0.27(0.19-0.37)and 0.05(0.00-0.14), respectively. When adjusted for area and age, the heritability of these three behaviors were 0.26(0.19-0.34), 0.31(0.00-0.74)and 0.05(0.00-0.14), respectively. CONCLUSIONS All the three smoking related behaviors were affected by genetic factors, but environment factors had more effect on them. For smoking cessation, the heritability was highest, but the influence of environmental factors was lowest. Meanwhile, for onset age of smoking, the influence of environmental factors was highest.
Further improvement of an efficient password based remote user authentication scheme using smart cards

Recently, Ku-Chen proposed an improvement to Chien et al.'s scheme to prevent from some weaknesses. However, the improved scheme is not only still susceptible to parallel session attack, but also insecure for changing the user's password in password change phase. Accordingly, the current paper presents an enhancement to resolve such problems. As a result, the proposed scheme enables users to change their passwords freely and securely without the help of a remote server, while also providing secure mutual authentication.
Alamethicin: a peptide model for voltage gating and protein-membrane interactions.

CONTENTS PERSPECTIVES AND OVERVIEW 1 41 ENERGETIC REQUIREMENTS FOR ION TRANSPORT. 1 43 GENERAL FEATURES AND SEQUENCE OF ALAMETHICIN . 1 45 CHANNEL ACTIVITY OF ALAMETHlCIN . 1 46 Macroscopic Conductances in Planar Bilayers . 1 46 Single Channel Conductance Measurements . 1 47 Conductance Measurements in Vesicles . 147 The Activity of Alamethicin Analogues . 1 49 STRUCTURE AND DYNAMICS OF ALAMETHICIN . 150 Crystal Structure . 150 Structure Derived from Spectroscopic Studies 1 52 Membrane Binding and Aggregation of Alamethicin . 154 MODELS FOR THE ALAMETHICIN CHANNEL . 156 Structure of the Ion Channel . 156 Models for Voltage-Dependent Gating . , . : . 1 57 Additional Mechanisms and Structural Considerations . 1 60 FUTURE DIRECTIONS 161
The relationships among environmental management, firm value and other firm attributes: evidence from Chinese manufacturing industry

Many studies have investigated the relationships among environmental management, financial performance and other firm attributes. Their results are inconsistent and contested. Most of the empirical studies to date are in the context of developed countries rather than developing countries. This study fills this gap by providing an empirical examination of the relationships among environmental management, firm value and other firm attributes in the Chinese context. In addition, this study is the first study of Chinese firms to use panel data analysis methods in the examination of the impact of environmental management on firm value. The results of panel data analysis show that environmental management has no significant impact on firm value. Pearson tests show that prior financial performance does not affect the level of environmental management. Rather, firm size is shown to be positively correlated with the level of environmental management.
Assessing the bank profitability in the MENA region: A comparative analysis between conventional and Islamic bank

Purpose - – Which of the banking stream is relatively more profitable in Middle Eastern and North Africa (MENA) region? Design/methodology/approach - – The empirical study covers a sample of 15 conventional and 15 Islamic banks for the period 2002-2009.The authors estimate models using the generalized method of moments in system, of Blundell and Bond (1998). They exploit an up-to-date econometric technique which takes into consideration the issue of endogeneity of regressors to evaluate the comparative profitability of Islamic and conventional banks in the MENA region. Findings - – Empirical analysis results show that the determinants’ significance varies between Islamic and conventional banks. Profitability seems to be quite persistent in the MENA region reflecting a higher degree of government intervention and may signal barriers to competition. Originality/value - – The main interest is to develop a comprehensive model that integrates macroeconomic, industry-specific and bank-specific determinants. The paper makes comparison of the performance between two different banking systems in the MENA region. The authors consider a variable crisis to gain additional insights into the impacts of the financial crisis on MENA banking sector.
Market orientation and performance in the public sector: the role of organizational commitment

Abstract Increased calls for transparency and accountability in government organizations underscores the need for a market orientation even in the public sector. The degree of market orientation and its effect on performance and on organizational commitment in government departments in three Australian states is considered. Results provide empirical support for a direct relationship between market orientation and performance and evidence of the mediating role of organizational commitment. Implications are drawn and directions for future research are discussed.
Some results on relocation policies

In this paper, we derive general results concerning optimal relocation policy under some assumptions. We consider a firm that is located in a specific location, producing at a certain level of efficiency. With time, the firm can decide to change its location to a new and more efficient site, paying relocation costs. Moreover, we assume that these new sites become available according to a Poisson process, and that the levels of efficiency improvement inherent to each one of these sites are random variables. With this framework, we characterise certain parameters of the optimal relocation policy. In particular, we characterise the expected relocation time and we prove that it depends on the distribution of the level of efficiency improvement only through an expected value. Therefore, the optimal policy shows a kind of robustness in terms of the stochastic assumptions of the problem, which has a major impact in the application of relocation policies. In addition, we also characterise the optimal relocation time. Impacts on the final results driven by the characteristics of the firm's original location site, the market environment and the way in which risk is modelled are studied numerically. The overall results are in line with economic intuition.
Reluctant Entrepreneurs: The Extent Achievements and Significance of Worker Takeovers in Europe

This book is about people who became entrepreneurs, as one of them put it, "not by choice but by necessity" - as a way of preserving their livelihoods and workplaces. It is about how, across Europe, many hundreds of companies, and many thousands of jobs, have been preserved by groups of workers who had the initiative and determination to take over failing and bankrupt enterprises, usually when no one else was prepared to. It is, more than anything, a book about change: how moribund organizations have been transformed and industrial capacity preserved and reconstructed; how new ways of working (and new roles for trade unionists) have developed; how established social and political ideas have been re-evaluated; how new networks and economic formations have emerged; and how men and women have surprised themselves by what they have become and have achieved. This international study reveals a striking mismatch between the achievements of entreprises taken over by their employees and their popular reputation for failure and mismanagement. Drawing on original research as well as work undertaken in the course of a policy study for the European Commission, the data and case studies from six countries provide a comprehensive picture of the circumstances under which Worker Take-Overs are attempted, how many there have been, the problems they face, how they tackle them, and how they perform - both commercially and as democratic organizations.
Evaluating a Hospital Nursing Internship

What is the value of formal internship programs for new nursing graduates? Are internships worth the resources they require? How does a nursing administrator answer these questions? A three-year study of one internship program at a university hospital provides some direction in developing or deciding to develop a formal nursing internship. The authors compare the role transition experienced by the interns to role transition for nurses in a traditional hospital orientation program. Their conclusions suggest new evaluation criteria and areas for further study.
Building the health news agenda in local newspapers: Lessons for health-care managers

Abstract Health news is a significant source of health information for many Americans, and recent research has explored how health news is produced from the theoretical perspective of agenda building. In addition, work in public health and mass communication has focused on the significance of the health literacy concept as a tool for journalists and as a rubric for evaluating media messages. However, little is known about health news agenda building or health literacy in relation to local newspapers. This study explores the health news agenda-building process from the perspective of both newspaper journalists and administrators from local public health organizations in one Midwestern state through online and telephone surveys. Results show that public health professionals and journalists offer significantly different definitions of health literacy and interpretations of what should constitute the health news agenda.
Geographies of International Trade: Theory, Borders, and Regions

As old as civilization itself, international trade is fundamentally important to the economic well-being of nations and their regions. As with any other economic activity, international trade has a geography. Despite this geographic nature of international trade, it is a relatively unexplored topic by economic geographers. This is not to say that economic geographers do not investigate international economic activity, only that they do not study the more general processes of international trade. In this paper, I review three facets of international trade that imply the importance of geography undertaken by economists and geographers: theory, borders, and regions. Recent theoretical research implicates the importance of geography as an integral component of trade theory; the political geography of trade (borders) is shown to have differential effects in different regions; and the formation of regional trading blocs reveals that geography is still important for understanding international relationships. All three of these facets are fundamentally geographical. It is argued here that the discipline of economic geography must broaden its scope in order to apply a geographical imagination to the understanding of international trade.
Valuegenesis - Ten Years Later : A Study of Two Generations

Author Faculty (Discipline) Theology Document Type Book Publication Date 2004 Publication Details This book was originally published as: Gillespie, V. B. , Donahue, M. J., Gane, A. B. , & Boyatt, C. E. (2004). Valuegenesis ten years later : a study of two generations. Riverside, CA: Hancock Center Publication. ISBN: 9780974853109 Abstract What are the "big things" we've learned in our research of Adventist youth? What's the good news? What's the flip side? How important is the family in a student's quest for a spiritual life? Ten Years Later: A Study of Two Generations, answers these questions, and many more. A must read for youth pastors, educators, or parents who wants to have a positive impact on students and their journey of faith. [from publisher's website] Comments Due to copyright restrictions this book is unavailable for download. Staff and Students of Avondale may access the book from Avondale Library (234.20835 G41) The book may be accessed from the publisher here. Recommended Citation Gillespie, V. B. , Donahue, M. J., Gane, A. B. , & Boyatt, C. E. (2004). Valuegenesis ten years later : A study of two generations. Riverside, CA: Hancock Center.  Link to Full Text
Ethical judgement, locus of control, and whistleblowing intention: a case study of mainland Chinese MBA students

The purpose of this study is to investigate the ethics of whistleblowing in Chinese society. A framework is suggested to explain whistleblowing behaviour in terms of the individual’s locus of control and subjective judgement regarding the intention of whistleblowing. Hypotheses derived from these speculations are tested with data from Chinese MBA students (n = 254). Statistical analysis largely supports the hypotheses, and the implications of the findings are discussed.
Self-reported Alcohol Use and Depressive Symptoms After Liver Transplantation

Background The prevalence of alcohol use among Finnish liver transplant recipients has not been studied before. Methods We used self-report questionnaires and correlations between alcohol use liver biochemistry and depressive symptoms at the only transplant unit of the country, during a 6-month period in 2013. Results The final study population consisted of 207 recipients. After verbal consent, participants filled in Alcohol Use Disorder Identification Test C and Beck Depression Inventory-II. Twenty percent of patients had been transplanted because of alcoholic liver disease. Of the patients, 43% reported alcohol use any time after liver transplantation (LT) and 28% during the past 1 month. Nearly all of those who received LT during childhood reported alcohol use more often and more drinks per occasion. Statistically significant risk factors for harmful drinking were male sex, age younger than 18 years at transplantation, and years from transplantation. Neither cause nor the depression scores reached statistical significance. Alcohol users had statistically significant higher liver biochemistry markers. Conclusion Our results revealed a 43% overall use of alcohol after LT and 28% use of alcohol within the last month and low depression scores. Among participants with alcohol liver disease origin, 39% and 34% any time and during the past 1 month, respectively, reported relapse. The alcohol consumption revealed in this study is similar to that of the general alcohol consumption tradition in Finland. Young males transplanted during their childhood were at most risk for harmful drinking.
The changing roles of production and operations managers in Britain from the 1970s to the 1990s

This article examines the careers and changing roles of British production and operations managers through three surveys covering the last quarter of the twentieth century. Careers are examined in terms of both their organisational context and the subjective experiences of those who have chosen this field, during a period of great turbulence for manufacturing due to growing global competition. The persistent features of such roles and responsibilities are contrasted with the changes in focus and demands. The managers' sources of satisfaction and frustration are outlined as are their perceptions of their situation in relation to managers in other areas. The article concludes by considering what has changed and what needs to change, in order for manufacturing to gain maximum benefit from the contribution of these managers.
Interest-Rate Volatility, Basis Risk and Heteroscedasticity in Hedging Mortgages

This paper investigates the validity of the OLS regression to estimate the hedge ratio for mortgages (GNMA) and provides alternative methodologies. In particular, this paper is concerned with the variance structure (conditional and unconditional heteroscedasticities) and the misspecification (nonlinearities) of the simple linear regression model for direct as well as cross-hedging. Using data on spot prices of GNMA and futures prices of GNMAs and T-bills for the period September 1979 to January 1985, we show that there exists significant heteroscedasticity particularly for cross-hedging, and nonlinearity between cash and futures prices for direct as well as cross-hedging. Alternative hedge ratio estimates are provided using the Box-Cox transformation model and an autoregressive conditional heteroscedastic (ARCH) Model. Copyright American Real Estate and Urban Economics Association.
The relationship between the real exchange rate and balance of payments: empirical evidence for China from cointegration and causality testing

This article examines the relationship between the renminbi real exchange rate and China's foreign exchange reserves using cointegration and Granger causality testing. The main findings are that in the long run foreign exchange reserves Granger cause the real exchange rate. Meanwhile, in the short run there is unidirectional Granger causality running from foreign exchange reserves to the real exchange rate.
Evidence of Capacity Constraints in Insurance Markets

This article provides empirical support for the primary predictions of capacity constraint theories of property-casualty insurance cycles. The primary implications concern industry capacity and the difference between the price of insurance and noncapital costs, referred to here as the price-payment margin (PPM). Capacity constraint theories predict that low capacity will lead to higher PPMs and that capacity growth will follow PPM increases as insurers rebuild capacity. Price-payment margin and capacity series are constructed using industry time series for 1949-90. The estimation finds that PPM growth varies inversely with capacity at the beginning of the period and also inversely with changes in capacity. In addition, declines in capacity are associated with PPM growth next period, while increases in capacity generally have no significant effect on next period's PPM growth. Furthermore, current capacity growth is positively correlated with last period's PPM growth.
Intellectual capital‐in‐action and value creation: A case study of knowledge transformations in an innovation project

Purpose – This paper investigates the inter‐relationships between different components of intellectual capital (IC) and value creation.Design/methodology/approach – A single in‐depth case‐study of an innovation project within an Australian financial services firm (“TransactCo”) is conducted.Findings – The actual IC inter‐relationships and transformations that occurred were different to those originally envisaged by organisational participants, and reflected choices about IC deployment and transformation. Considering IC‐in‐action, inter‐relationships between different IC elements and value creation were found to be pluralistic and temporally contingent.Research limitations/implications – The limitations of the paper are as follows: the use of a single case study design limits its generalisability; the empirical analyses was conducted at a project‐level and may not be transferable to other levels of analyses; and a narrow conception of value was utilised, grounded in economic value and shareholder value ter.