Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of vitamin B12 deficiency in healthy Indian school‐going adolescents from rural and urban localities and its relationship with various anthropometric indices: a cross‐sectional study

BACKGROUND Micronutrient deficiency is a global health burden, especially among developing countries. The present cross-sectional study aimed to determine the prevalence of vitamin B12 deficiency in healthy Indian school-going adolescents, based on area of residence, sex and body mass index (BMI). Furthermore, the relationship of serum B12 concentration with dietary vitamin B12 intake and anthropometric indices was assessed among adolescents from rural and urban India. METHODS A total of 2403 school-going adolescents (11-17 years) from National Capital Region and rural areas of Haryana, India were selected. Serum B12 concentrations were estimated using an electrochemiluminescence immunoassay. Dietary assessments were conducted on 65% of total participants (n = 1556) by two 24-h diet recalls. RESULTS The prevalence of vitamin B12 deficiency in the total study population was 32.4% (rural: 43.9% versus urban: 30.1%, P < 0.001; male: 34.4% versus female: 31.0%, P < 0.05; normal weight: 28.1%, versus overweight: 39.8%, versus obese: 51.2%, P < 0.001). More than half (51.2%) of obese adolescents were vitamin B12 deficient. On multiple linear regression analysis, serum B12 in rural adolescents was associated with age (β = -0.12, P < 0.05). Among urban adolescents, serum B12 was associated with BMI (β = -0.08, P < 0.05) and adjusted dietary vitamin B12 intake (β = 0.14, P < 0.001). Serum vitamin B12 levels were found to be lower in rural females (β = -0.12, P = 0.030) and urban males (β: 0.11, P < 0.001) compared to their respective contemporaries. CONCLUSIONS Vitamin B12 deficiency was higher among rural school-going adolescents. Boys had a higher B12 deficiency than girls. Inverse associations of serum B12 with adiposity indices were observed. Serum B12 levels were positively associated with dietary vitamin B12 intake.
Towards Understanding Generalization via Analytical Learning Theory

This paper introduces a novel measure-theoretic theory for machine learning that does not require statistical assumptions. Based on this theory, a new regularization method in deep learning is derived and shown to outperform previous methods in CIFAR-10, CIFAR-100, and SVHN. Moreover, the proposed theory provides a theoretical basis for a family of practically successful regularization methods in deep learning. We discuss several consequences of our results on one-shot learning, representation learning, deep learning, and curriculum learning. Unlike statistical learning theory, the proposed learning theory analyzes each problem instance individually via measure theory, rather than a set of problem instances via statistics. As a result, it provides different types of results and insights when compared to statistical learning theory.
Significance of cytogenetic abnormalities in patients with polycythemia vera

Abstract We analyzed 133 patients with polycythemia vera (PV) who were followed at our institution (median 7.5 years) and had adequate cytogenetics information. The 5-, 10- and 15-year survival rates were 93%, 79% and 64%, respectively, with a median projected overall survival of 24 years. Nineteen patients (14%) had abnormal cytogenetics at any time during the disease course (no survival difference). Sixteen patients (12%) underwent disease transformation during follow-up, after a median of 8.5 years, to myelofibrosis (n = 11), acute myeloid leukemia (n = 4) or myelodysplastic syndrome (n = 1); eight had cytogenetic abnormalities. Among 133 patients, 39 were newly diagnosed: 33 with normal and six with abnormal cytogenetics (no survival difference); nine underwent disease transformation (six with normal and three with abnormal cytogenetics at diagnosis). In keeping with other smaller series, the presence of chromosomal abnormalities may have had a role in disease transformation in patients with PV; survival was not affected likely due to short follow-up.
Clinical Impact of ITCA 650, a Novel Drug-Device GLP-1 Receptor Agonist, in Uncontrolled Type 2 Diabetes and Very High Baseline HbA1c: The FREEDOM-1 HBL (High Baseline) Study

OBJECTIVE ITCA 650 is a subdermal osmotic mini-pump that continuously delivers exenatide subcutaneously for 3–6 months. The efficacy, safety, and tolerability of ITCA 650 added to diet and exercise alone or combined with metformin, sulfonylurea, or thiazolidinedione monotherapy or a combination of these drugs was evaluated in poorly controlled patients with type 2 diabetes (T2D) who were ineligible for participation in a placebo-controlled study (FREEDOM-1) because of severe hyperglycemia (HbA1c >10% [86 mmol/mol]). RESEARCH DESIGN AND METHODS This 39-week, open-label, phase 3 trial enrolled patients aged 18–80 years with HbA1c >10% to ≤12% (86–108 mmol/mol) and BMI 25–45 kg/m2. Patients received ITCA 650 20 μg/day for 13 weeks, then 60 μg/day for 26 weeks. The primary end point was change in HbA1c at week 39. RESULTS Sixty patients were enrolled. At baseline, mean HbA1c was 10.8% (94.7 mmol/mol) and mean (± SD) duration of diabetes was 8.6 (± 5.3) years. At week 39, there was a mean reduction in HbA1c of −2.8% (−30.3 mmol/mol; P < 0.001 vs. baseline) and in body weight of −1.2 kg (P = 0.105), and 25% of patients achieved HbA1c <7% (53 mmol/mol). A reduction in HbA1c of ≥1% (≥10.9 mmol/mol) occurred in 90% of patients. The most common adverse events were nausea, vomiting, diarrhea, and headache. Gastrointestinal adverse events were generally transient and subsided over time; only 4 patients (6.7%) discontinued for gastrointestinal events. CONCLUSIONS Treatment with ITCA 650, the first injection-free glucagon-like peptide 1 receptor agonist, resulted in significant improvements in glycemic control in poorly controlled long-standing T2D patients with a high baseline HbA1c >10%.
A Dichotomy for Regular Expression Membership Testing

We study regular expression membership testing: Given a regular expression of size m and a string of size n, decide whether the string is in the language described by the regular expression. Its classic O(nm) algorithm is one of the big success stories of the 70s, which allowed pattern matching to develop into the standard tool that it is today.Many special cases of pattern matching have been studied that can be solved faster than in quadratic time. However, a systematic study of tractable cases was made possible only recently, with the first conditional lower bounds reported by Backurs and Indyk [FOCS16]. Restricted to any type of homogeneous regular expressions of depth 2 or 3, they either presented a near-linear time algorithm or a quadratic conditional lower bound, with one exception known as the Word Break problem.In this paper we complete their work as follows:&#x2022; We present two almost-linear time algorithms that generalize all known almost-linear time algorithms for special cases of regular expression membership testing. &#x2022; We classify all types, except for the Word Break problem, into almost-linear time or quadratic time assuming the Strong Exponential Time Hypothesis. This extends the classification from depth 2 and 3 to any constant depth. &#x2022; For the Word Break problem we give an improved O(nm1/3 + m) algorithm. Surprisingly, we also prove a matching conditional lower bound for combinatorial algorithms. This establishes Word Break as the only intermediate problem.In total, we prove matching upper and lower bounds for any type of bounded-depth homogeneous regular expressions, which yields a full dichotomy for regular expression member-ship testing.
ON THE CONNECTION BETWEEN MICROBURSTS AND NONLINEAR ELECTRONIC STRUCTURES IN PLANETARY RADIATION BELTS

Using a dynamical-system approach, we have investigated the efficiency of large-amplitude whistler waves for causing microburst precipitation in planetary radiation belts by modeling the microburst energy and particle fluxes produced as a result of nonlinear wave–particle interactions. We show that wave parameters, consistent with large-amplitude oblique whistlers, can commonly generate microbursts of electrons with hundreds of keV-energies as a result of Landau trapping. Relativistic microbursts (>1 MeV) can also be generated by a similar mechanism, but require waves with large propagation angles θ kB > 50 ° ? > and phase-speeds v Φ ≥ c / 9 ? > . Using our result for precipitating density and energy fluxes, we argue that holes in the distribution function of electrons near the magnetic mirror point can result in the generation of double layers and electron solitary holes consistent in scales (of the order of Debye lengths) to nonlinear structures observed in the radiation belts by the Van Allen Probes. Our results indicate a relationship between nonlinear electrostatic and electromagnetic structures in the dynamics of planetary radiation belts and their role in the cyclical production of energetic electrons ( E ≥ 100 ? > keV) on kinetic timescales, which is much faster than previously inferred.
Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

Pathogen-specific responses are characterized by preferred profiles of peptide+class I MHC (pMHCI) glycoprotein-specific T-cell receptor (TCR) Variable (V)-region use. How TCRV-region bias impacts TCRαβ heterodimer selection and resultant diversity is unclear. The DbPA224–specific TCR repertoire in influenza A virus-infected C57BL/6J (B6) mice exhibits a preferred TCRV-region bias toward the TRBV29 gene segment and an optimal complementarity determining region (CDR3) β-length of 6 aa. Despite these restrictions, DbPA224-specific BV29+ T cells use a wide array of unique CDR3β sequences. Structural characterization of a single, TRBV29+DbPA224-specific TCRαβ-pMHCI complex demonstrated that CDR3α amino acid side chains made specific peptide interactions, but the CDR3β main chain exclusively contacted peptides. Thus, length but not amino acid sequence was key for recognition and flexibility in Vβ-region use. In support of this hypothesis, retrovirus expression of the DbPA224-specific TCRVα-chain was used to constrain pairing within a naive/immune epitope-specific repertoire. The retrogenic TCRVα paired with a diversity of CDR3βs in the context of a preferred TCRVβ spectrum. Overall, these data provide an explanation for the combination of TCRV region bias and diversity within selected repertoires, even as they maintain exquisite pMHCI specificity.
Serum Potassium Levels and Short-Term Outcomes in Patients With ST-Segment Elevation Myocardial Infarction

Current guidelines recommend maintaining serum potassium levels between 4.0 and 5.0 mEq/L (1 mEq/L = mmol/L) in patients with acute myocardial infarction. However, these guidelines are based on studies conducted before the β blocker and reperfusion era. We retrospectively analyzed 6613 patients diagnosed with ST-segment elevation myocardial infarction (STEMI) who presented without renal insufficiency. Patients were categorized into 5 groups according to mean serum potassium levels: <3.5, 3.5 to <4.0, 4.0 to <4.5, 4.5 to <5.0, and ≥5.0 mEq/L. Patients with potassium levels of 4.0 to <4.5 mEq/L had the lowest predefined event rates, which were 6.4% for 7-day malignant arrhythmia, 3.7% for 7-day mortality, and 5.3% for 30-day mortality. Compared with the reference group (4.0 to <4.5 mEq/L), multivariate regression analysis revealed significantly higher 30-day mortality risk in patients with potassium level of 4.5 to <5.0 (hazard ratio [HR]: 1.52, 95% confidence interval [CI]: 1.17-1.98; P = .002) and even higher risk in patients with potassium level of ≥5.0 mEq/L (HR: 1.80, 95% CI: 1.22-2.66; P = .002). The lowest 30-day mortality was observed in patients with STEMI having potassium levels between 4.0 and 4.5 mEq/L, and a level >4.5 mEq/L significantly increased mortality risk.
Lack of Diagnostic Pluripotentiality in Patients at Clinical High Risk for Psychosis: Specificity of Comorbidity Persistence and Search for Pluripotential Subgroups

More than 20 years after the clinical high risk syndrome for psychosis (CHR) was first articulated, it remains controversial whether the CHR syndrome predicts onset of psychosis with diagnostic specificity or predicts pluripotential diagnostic outcomes. Recently, analyses of observational studies, however, have suggested that the CHR syndrome is not pluripotential for emergent diagnostic outcomes. The present report conducted additional analyses in previously reported samples to determine (1) whether comorbid disorders were more likely to persist in CHR patients compared to a comparison group of patients who responded to CHR recruitment efforts but did not meet criteria, termed help-seeking comparison subjects (HSC); and (2) whether clinically defined pluripotential CHR subgroups could be identified. All data were derived from 2 multisite studies in which DSM-IV structured diagnostic interviews were conducted at baseline and at 6-month intervals. Across samples we observed persistence of any nonpsychotic disorder in 80/147 CHR cases (54.4%) and in 48/84 HSC cases (57.1%, n.s.). Findings with persistence of anxiety, depressive, and bipolar disorders considered separately were similar. Efforts to discover pluripotential CHR subgroups were unsuccessful. These findings add additional support to the view that the CHR syndrome is not pluripotential for predicting various diagnostic outcomes but rather is specific for predicting emergent psychosis.
The Influence of the Coarse Wool Treatment on Fiber Structure and Physico-Mechanical Parameters

In this research, the influence of slendering on coarse wool fiber which then improved by m-TGase treatment was studied. The coarse wool fiber was first treated by reducing agent then it was stretched at different conditions over various periods of times and temperatures and finally steam set. The wool fibers were then tested for some mechanical and physical properties. To overcome tenacity loss of the fibers as a result of slendering treatment, after-treatment with microbial trans-glutaminases was examined. The results show that the fineness of the fiber was improved about 17% but the tenacity decreased about 15%. XRD analysis show that the degree of crystallinity related to stretching ratio and this increasing of stretching alters the degree of crystallinity. SEM shows that the cuticle of the treated samples causes excessive damage and the reducing agent can affect on wool surface. Furthermore, alkaline solubility was increased by reduction treatment, but m-TGase can compensate a little. The fiber yellowness was significantly decreased after slendering.
Expression of MAGE‐A and NY‐ESO‐1 cancer/testis antigens is enriched in triple‐negative invasive breast cancers

A better understanding of the expression of cancer/testis antigens (CTAs) in breast cancer might enable the identification of new immunotherapy options, especially for triple‐negative (TN) tumours, which lack expression of the conventional therapeutic targets oestrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. The aim of this study was to quantify the expression of MAGE‐A and NY‐ESO‐1 CTAs in breast cancer, and relate this to known clinicopathological parameters.
Mechanism of Oxidative Stress in Neurodegeneration

Biological tissues require oxygen to meet their energetic demands. However, the consumption of oxygen also results in the generation of free radicals that may have damaging effects on cells. The brain is particularly vulnerable to the effects of reactive oxygen species due to its high demand for oxygen, and its abundance of highly peroxidisable substrates. Oxidative stress is caused by an imbalance in the redox state of the cell, either by overproduction of reactive oxygen species, or by dysfunction of the antioxidant systems. Oxidative stress has been detected in a range of neurodegenerative disease, and emerging evidence from in vitro and in vivo disease models suggests that oxidative stress may play a role in disease pathogenesis. However, the promise of antioxidants as novel therapies for neurodegenerative diseases has not been borne out in clinical studies. In this review, we critically assess the hypothesis that oxidative stress is a crucial player in common neurodegenerative disease and discuss the source of free radicals in such diseases. Furthermore, we examine the issues surrounding the failure to translate this hypothesis into an effective clinical treatment.
Steer‐PROP: a GRASE‐PROPELLER sequence with interecho steering gradient pulses

This study demonstrates a novel PROPELLER (periodically rotated overlapping parallel lines with enhanced reconstruction) pulse sequence, termed Steer‐PROP, based on gradient and spin echo (GRASE), to reduce the imaging times and address phase errors inherent to GRASE. The study also illustrates the feasibility of using Steer‐PROP as an alternative to single‐shot echo planar imaging (SS‐EPI) to produce distortion‐free diffusion images in all imaging planes.
Particle swarm optimization based resource block allocation algorithm for downlink LTE systems

The problem of resource block allocation for downlink Long Term Evolution (LTE) systems is addressed. To maximize system throughput and fulfill quality of service (QoS) requirements among users and modulation and coding scheme (MCS) selection constraint brought by LTE, a Particle Swarm Optimization (PSO) based resource block allocation algorithm is designed. That is, we propose a coding scheme to map solutions onto particles, and find an operation to discretize the position and velocity of particles and then establish a fitness function after handling constraints through penalty function. Simulations show that the proposed algorithm outperforms in the achievement of high system throughput with QoS guarantee when resource is enough and plays a worthwhile tradeoff between QoS and throughput in overloaded systems.
Rapid visuomotor feedback gains are tuned to the task dynamics

Here, we test whether rapid visuomotor feedback responses are selectively tuned to the task dynamics. The responses do not exhibit gain scaling, but they do vary with the level and stability of task dynamics. Moreover, these feedback gains are independently tuned to perturbations to the left and right, depending on these dynamics. Our results demonstrate that the sensorimotor control system regulates the feedback gain as part of the adaptation process, tuning them appropriately to the environment.
Estimating Sex Using Metric Analysis of the Scapula by Postmortem Computed Tomography

Postmortem computed tomography (CT) has been extensively used in the last decade for identification purposes and in various anthropologic studies. Postmortem CT measurements of scapulae, analyzed using logistic discriminant function developed in this study, showed 94.5% accuracy in estimating sex. Data analyzed using the Dabbs and Moore‐Jansen (2010) discriminant function and the discriminant function generated in this study provided nearly identical results with disagreement in only one case. Height and weight were not statically significant in sex prediction. The results of this study show that data obtained from volume rendered postmortem CT images can be considered reliable and treated as a practical option to standard anthropological methods, especially in mass fatalities as a rapid triage tool for sex determination.
A Self-Test on Wafer Level for a MEM Gyroscope Readout Based on $\Delta \Sigma$ Modulation

This paper presents the implementation of a self-test for a gyroscope readout based on electro-mechanical <inline-formula> <tex-math notation="LaTeX">$\Delta \Sigma$ </tex-math></inline-formula> modulation. Commonly, sensor element and readout ASIC are fabricated on separate wafers. Therefore, the ability to separately characterize the sensor element and the ASIC before packaging is desirable in order to reduce unnecessary expense. For the proposed self-test, a charge integrator with collocated detection and feedback is configured to generate an additional feedback path, which is used to operate a purely electrical <inline-formula> <tex-math notation="LaTeX">$\Delta \Sigma$ </tex-math></inline-formula> modulator on wafer level. The self-test is performed in two steps. First, an automatic compensation controller configures the collocated force-feedback and thereby verifies its functionality. In a second step, an offset is added to the settled value of the controller to generate a negative feedback path to the input of the readout interface. The resulting purely electrical <inline-formula> <tex-math notation="LaTeX">$\Delta \Sigma$ </tex-math></inline-formula> modulator is utilized to validate the functionality of every single circuit component of the later operated electro-mechanical <inline-formula> <tex-math notation="LaTeX">$\Delta \Sigma$ </tex-math></inline-formula> modulator. The proposed self-test makes use of the already available hardware and therefore avoids an additional hardware overhead. Numerical simulations are performed to verify the proposed compensation controller concept as well as the self-test itself. The simulation results of the self-test are confirmed by measurements.
Association study of KIBRA gene with memory performance in a Japanese population

Abstract Objectives. Papassotiropoulos et al. (Science 314: p 475) discovered that a single nucleotide polymorphism (SNP) of the KIBRA gene (rs17070145) was associated with delayed recall performance in Caucasians. KIBRA is highly expressed in the brain and kidneys, and is reported to be involved in synaptic plasticity. Therefore, we first tried to replicate the association between the SNP and memory performance in a Japanese subjects. Methods. We examined the association between the SNP and memory performance measured by the Wechsler Memory Scale-Revised (WMS-R) in 187 healthy Japanese people. Results. The T allele carriers had significantly better verbal memory, attention/concentration and delayed recall performance than the C/C carriers (corrected P = 0.044, 0.047 and 0.0084, respectively). Furthermore, the C/T carriers and the T/T carriers had better delayed recall performance than the C/C carriers (post hoc P = 0.0017 and 0.0096). Conclusions. This data suggest that the C/C genotype might have an impact on memory performance in Asian populations as well as in Caucasian populations. Further investigation to clarify the association of the KIBRA gene with memory in other ethnic groups is warranted.