Miracle-dz/UniFAR-FTUs huggingface dataset:
A chronology of human understanding of the nitrogen cycle†

Nitrogen over the ages! It was discovered in the eighteenth century. The following century, its importance in agriculture was documented and the basic components of its cycle were elucidated. In the twentieth century, a process to provide an inexhaustible supply of reactive N (Nr; all N species except N2) for agricultural, industrial and military uses was invented. This discovery and the extensive burning of fossil fuels meant that by the beginning of the twenty-first century, anthropogenic sources of newly created Nr were two to three times that of natural terrestrial sources. This caused a fundamental change in the nitrogen cycle; for the first time, there was the potential for enough food to sustain growing populations and changing dietary patterns. However, most Nr created by humans is lost to the environment, resulting in a cascade of negative earth systems impacts—including enhanced acid rain, smog, eutrophication, greenhouse effect and stratospheric ozone depletion, with associated impacts on human and ecosystem health. The impacts continue and will be magnified, as Nr is lost to the environment at an even greater rate. Thus, the challenge for the current century is how to optimize the uses of N while minimizing the negative impacts.
Job strain and the risk of disability pension due to musculoskeletal disorders, depression or coronary heart disease: a prospective cohort study of 69 842 employees

Objectives Observational studies suggest that high job strain is a risk factor for retirement on health grounds, but few studies have analysed specific diagnoses. We examined job strain's association with all-cause and cause-specific disability pensions. Methods Survey responses to questions about job strain from 48 598 (response rate, 68%) public sector employees in Finland from 2000 to 2002 were used to determine work unit- and occupation-based scores. These job strain scores were assigned to all the 69 842 employees in the same work units or occupations. All participants were linked to the disability pension register of the Finnish Centre of Pensions with no loss to follow-up. Cox proportional hazard models were used to calculate HRs and their 95% CIs for disability pensions adjusted by demographic, work unit characteristics and baseline health in analyses stratified by sex and socioeconomic position. Results During a mean follow-up of 4.6 years, 2572 participants (4%) were granted a disability pension. A one-unit increase in job strain was associated with a 1.3- to 2.4-fold risk of requiring a disability pension due to musculoskeletal diseases in men, women and manual workers, depending on the measure of job strain (work unit or occupation based). The risk of disability pension due to cardiovascular diseases was increased in men with high job strain but not in women nor in any socioeconomic group. No consistent pattern was found for disability pension due to depression. Conclusion High job strain is a risk factor for disability pension due to musculoskeletal diseases.
Butyrylated starch affects colorectal cancer markers beneficially and dose-dependently in genotoxin-treated rats

Population studies suggest that greater dietary fiber intake may lower colorectal cancer (CRC) risk, possibly through the colonic bacterial fermentative production of butyrate. Butyrylated starch delivers butyrate to the colon of humans with potential to reduce CRC risk but high doses may exacerbate risk through promoting epithelial proliferation. Here we report the effects of increasing dietary butyrylated high amylose maize starch (HAMSB) on azoxymethane (AOM) induced distal colonic DNA damage, cell proliferation, mucus layer thickness and apoptosis in rats. Five groups of 15 rats were fed AIN-93G based diets containing 0–40% HAMSB for 4 weeks then injected with (AOM) and killed 6 hours later. Large bowel total SCFA, acetate and butyrate pools and hepatic portal venous plasma total SCFA, acetate and butyrate concentrations were higher with greater HAMSB intake. Distal colonic epithelial apoptotic index and colonic mucus thickness increased, while DNA single strand breaks decreased dose-dependently with greater HAMSB intake. Colonocyte proliferation rates were unaffected by diet. These data suggest that increasing large bowel butyrate may reduce the risk of CRC in a dose dependent manner by enhancing apoptotic surveillance in the colonic epithelium for damaged cells without promoting the risk of tumorigenesis through increased cell proliferation.
Consumer preferences for micronutrient strategies in China. A comparison between folic acid supplementation and folate biofortification

Abstract Objective Despite public health efforts, folate deficiency is still largely prevalent in poor, rural populations and continues to cause a large burden of disease. The present paper determines and compares consumer preferences for two folate strategies: folic acid supplementation v. folate biofortification, i.e. the enhancement of the folate content in staple crops. Design Experimental auctions with non-repeated information rounds are applied to rice in order to obtain willingness-to-pay for folate products. Thereby, GM or non-GM folate-biofortified rice (FBR) is auctioned together with rice that is supplemented with free folic acid pills (FAR). Setting Shanxi Province (China) as a high-risk region of folate deficiency. Subjects One hundred and twenty-six women of childbearing age, divided into a school (n 60) and market sample (n 66). Results Despite differences according to the targeted sample, a general preference for folate biofortification is observed, regardless of the applied breeding technology. Premiums vary between 33·9 % (GM FBR), 36·5 % (non-GM FBR) and 19·0 % (FAR). Zero bidding behaviour as well as the product choice question, respectively, support and validate these findings. The targeted sample, the timing of the auction, the intention to consume GM food and the responsibility for rice purchases are considered key determinants of product choice. A novel ex-post negative valuation procedure shows low consistency in zero bidding. Conclusions While the low attractiveness of FAR provides an additional argument for the limited effectiveness of past folic acid supplementation programmes, the positive reactions towards GM FBR further support its potential as a possible complementary micronutrient intervention.
Variable-Mass Particle Filter for Road-Constrained Vehicle Tracking

The paper studies the road-constrained vehicle tracking problem employing the multiple-model particle filtering framework. It introduces an approach which enables for a more efficient particle use within the multimodel structure of the tracker; rather than allocating the particles to the various modes of operation using fixed mode probabilities, it proposes to allocate the particles freely according to user-defined application-specific criteria. For compensating for the arbitrary allocation of the particles, the particles are assigned with masses which scale appropriately their weights. Simulation results demonstrate the improved particle efficiency of the new variable-mass approach when contrasted with the standard variable-structure multiple model particle filter in a vehicle tracking application.
Comparison of heat and pressure treatments of skim milk, fortified with whey protein concentrate, for set yogurt preparation: effects on milk proteins and gel structure

Heat (85 °C for 20 min) and pressure (600 MPa for 15 min) treatments were applied to skim milk fortified by addition of whey protein concentrate. Both treatments caused > 90% denaturation of β-lactoglobulin. During heat treatment this denaturation took place in the presence of intact casein micelles; during pressure treatment it occurred while the micelles were in a highly dissociated state. As a result micelle structure and the distribution of β-lactoglobulin were different in the two milks. Electron microscopy and immunolabelling techniques were used to examine the milks after processing and during their transition to yogurt gels. The disruption of micelles by high pressure caused a significant change in the appearance of the milk which was quantified by measurement of the colour values L*, a* and b*. Heat treatment also affected these characteristics. Casein micelles are dynamic structures, influenced by changes to their environment. This was clearly demonstrated by the transition from the clusters of small irregularly shaped micelle fragments present in cold pressure-treated milk to round, separate and compact micelles formed on warming the milk to 43 °C. The effect of this transition was observed as significant changes in the colour indicators. During yogurt gel formation, further changes in micelle structure, occurring in both pressure and heat-treated samples, resulted in a convergence of colour values. However, the microstructure of the gels and their rheological properties were very different. Pressure-treated milk yogurt had a much higher storage modulus but yielded more readily to large deformation than the heated milk yogurt. These changes in micelle structure during processing and yogurt preparation are discussed in terms of a recently published micelle model.
Simvastatin Does Not Affect Vitamin D Status, but Low Vitamin D Levels Are Associated with Dyslipidemia: Results from a Randomised, Controlled Trial

Objectives. Statin drugs act as inhibitors of the 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) reductase enzyme early in the mevalonate pathway, thereby reducing the endogenous cholesterol synthesis. In recent studies, it has been suggested from epidemiological data that statins also may improve vitamin D status, as measured by increased plasma 25-hydroxyvitamin D (25OHD) levels. We now report the results from a randomised controlled trial on effects of simvastatin on plasma 25OHD levels. Design and Methods. We randomised 82 healthy postmenopausal women to one year of treatment with either simvastatin 40 mg/d or placebo and performed measurement at baseline and after 26 and 52 weeks of treatment. The study was completed by 77 subjects. Results. Compared with placebo, plasma levels of cholesterol and low-density lipoproteins decreased in response to treatment with simvastatin, but our study showed no effect of simvastatin on vitamin D status. However, plasma levels of triglycerides were inversely associated with tertiles of plasma 25OHD levels and changes in plasma triglycerides levels correlated inversely with seasonal changes in vitamin D status. Conclusion. Our data do not support a pharmacological effect of statins on vitamin D status, but do suggest that vitamin D may influence plasma lipid profile and thus be of importance to cardiovascular health.
Theoretical Comparisons of Positive-Unlabeled Learning against Positive-Negative Learning

In PU learning, a binary classifier is trained from positive (P) and unlabeled (U) data without negative (N) data. Although N data is missing, it sometimes outperforms PN learning (i.e., ordinary supervised learning). Hitherto, neither theoretical nor experimental analysis has been given to explain this phenomenon. In this paper, we theoretically compare PU (and NU) learning against PN learning based on the upper bounds on estimation errors. We find simple conditions when PU and NU learning are likely to outperform PN learning, and we prove that, in terms of the upper bounds, either PU or NU learning (depending on the class-prior probability and the sizes of P and N data) given infinite U data will improve on PN learning. Our theoretical findings well agree with the experimental results on artificial and benchmark data even when the experimental setup does not match the theoretical assumptions exactly.
Multi-modal Dimensional Emotion Recognition using Recurrent Neural Networks

Emotion recognition has been an active research area with both wide applications and big challenges. This paper presents our effort for the Audio/Visual Emotion Challenge (AVEC2015), whose goal is to explore utilizing audio, visual and physiological signals to continuously predict the value of the emotion dimensions (arousal and valence). Our system applies the Recurrent Neural Networks (RNN) to model temporal information. We explore various aspects to improve the prediction performance including: the dominant modalities for arousal and valence prediction, duration of features, novel loss functions, directions of Long Short Term Memory (LSTM), multi-task learning, different structures for early feature fusion and late fusion. Best settings are chosen according to the performance on the development set. Competitive experimental results compared with the baseline show the effectiveness of the proposed methods.
Impact of Surface Roughness on AMSR-E Sea Ice Products

This paper examines the sensitivity of Advanced Microwave Scanning Radiometer (AMSR-E) brightness temperatures (Tbs) to surface roughness by a using radiative transfer model to simulate AMSR-E Tbs as a function of incidence angle at which the surface is viewed. The simulated Tbs are then used to examine the influence that surface roughness has on two operational sea ice algorithms, namely: (1) the National Aeronautics and Space Administration Team (NT) algorithm and (2) the enhanced NT algorithm, as well as the impact of roughness on the AMSR-E snow depth algorithm. Surface snow and ice data collected during the AMSR-Ice03 field campaign held in March 2003 near Barrow, AK, were used to force the radiative transfer model, and resultant modeled Tbs are compared with airborne passive microwave observations from the Polarimetric Scanning Radiometer. Results indicate that passive microwave Tbs are very sensitive even to small variations in incidence angle, which can cause either an over- or underestimation of the true amount of sea ice in the pixel area viewed. For example, this paper showed that if the sea ice areas modeled in this paper were assumed to be completely smooth, sea ice concentrations were underestimated by nearly 14% using the NT sea ice algorithm and by 7% using the enhanced NT algorithm. A comparison of polarization ratios (PRs) at 10.7, 18.7, and 37 GHz indicates that each channel responds to different degrees of surface roughness and suggests that the PR at 10.7 GHz can be useful for identifying locations of heavily ridged or rubbled ice. Using the PR at 10.7 GHz to derive an "effective" viewing angle, which is used as a proxy for surface roughness, resulted in more accurate retrievals of sea ice concentration for both algorithms. The AMSR-E snow depth algorithm was found to be extremely sensitive to instrument calibration and sensor viewing angle, and it is concluded that more work is needed to investigate the sensitivity of the gradient ratio at 37 and 18.7 GHz to these factors to improve snow depth retrievals from spaceborne passive microwave sensors
Pulmonary Complications in Cirrhotic Candidates for Liver Transplantation

Background and Aims The determination of the prevalence of cardiopulmonary complications at a liver transplant center in Iran. Methods Ninety-nine patients (61 male and 38 female) with a mean age of 36.5 (15-66) years with proven cirrhosis were enrolled in this study. Patients with primary cardiac disease, current smokers, those with sepsis, hepatocellular carcinoma, recently ruptured esophageal varices and chronic pulmonary or renal diseases were excluded from the study. Sixty-nine patients had ascites. Forty-four patients had grade C Child-Pugh classification. All patients were evaluated for respiratory function by chest X-ray (CXR), room air arterial blood gas, simultaneous pulse oximetry, cardiac echocardiography and spirometry. Results Sixty-one patients (66.1%) had a widened alveolar-arterial O2 difference ( > 20 mmHg); 14 (14.1%) had hypoxemia; 6 (6.1%) had mean pulmonary arterial pressure (MPAP) = 25-40 mmHg; 12 (12.1%) had tricuspid regurgitation; pleural effusion and lung restriction were detected in 4 (4%) and 50 (50.5%), respectively. P(A-a)O2 was negatively associated with pulmonary hypertension (P < 0.03) and tricuspid regurgitation (P < 0.005). Portal hypertension and portal vein thrombosis were detected in 91 and 8 patients, respectively. Conclusions A widened alveolar-arterial oxygen difference was common in our patients, but hypoxemia occurred in 14% of patients. Portopulmonary hypertension was preponderant in those patients of male gender.
The Accuracy of Trigger Tools to Detect Preventable Adverse Events in Primary Care: A Systematic Review

Purpose: To understand the ability of trigger tools to detect preventable adverse events (pAEs) in the primary care outpatient setting using the Institute for Healthcare Improvement's (IHI) Outpatient Adverse Event Trigger Tool (IHI Tool). Methods: The OVID MEDLINE and OVID MEDLINE In-process and non-Indexed citations databases were queried using controlled vocabulary and Medical Subject Headings related to the concepts “primary care” and “adverse events. ” Included articles were conducted in the outpatient setting, used at least 1 of the triggers identified in the IHI Tool, and identified pAEs of any type. Articles were selected for inclusion based first on assessment of titles then abstracts by 2 trained reviewers independently, followed by full text review by 2 authors. Results: Our search identified 6435 unique articles, and we included 15 in our review. The most common studied trigger was laboratory abnormalities. The most common pAEs were medication errors followed by unplanned hospitalizations. The effectiveness of triggers in identifying AEs varied widely. Conclusion: There is insufficient data on the IHI Tool and its use to identify pAEs in the general real-world outpatient setting. Health care providers of the primary care setting may benefit from better trigger tools and other methods to help them detect pAEs. More research is needed to further evaluate the effectiveness of trigger tools to reduce barriers of cost and time and improve patient safety.
Utilization of animal fat waste as carbon source by carotenogenic yeasts – a screening study

Abstract Red yeast strains are ubiquitous microorganisms which accumulate substantial amounts of lipids and lipid-soluble metabolites. Red yeasts utilize many waste substrates of different origin. In this work red yeasts strains (Rhodotorula, Sporobolomyces, Cystofilobasidium) were used for screening of growth and metabolic activity. As a carbon source waste animal fat and its hydrolysis products were used. Hydrolysis of animal fat was tested in alkaline as well as acidic conditions. As the substrate glucose (control), glycerol, crude animal fat, acid fat hydrolyzate and hydrolysate: glucose 1:2 were used. Screening of growth and metabolic activity of red yeasts was performed by flow cytometry. Extracellular lipase production was monitored as adaptation mechanism. Carotenoids, ergosterol and ubiquinone were quantified by HPLC/PDA/MS/ESI and the biomass was evaluated gravimetrically. All tested strains utilized fat hydrolysate and produced red coloured biomass. Cultivation in media containing non-hydrolysed fat led to strain specific induction of extracellular lipase. Amount of lipid metabolites produced by individual strains was depended on glycerol content in medium. The highest increase of lipase production was observed in Cystofilobasidium macerans and Sporobolomyces shibatanus. Valorisation of animal fat can lead to production of unsaturated fatty acids, single cell oils, carotenoid pigments, sterols and enriched red yeast biomass.
Assessing the Prevalence of Trauma Exposure in Epidemiological Surveys

Objective: Estimates of the prevalence of exposure to potentially traumatic events (PTEs) in population surveys have increased over time. There is limited empirical evidence on the impact of changes in measurement practices on these estimates. The present study examined the effect of increasing the number of events assessed on the prevalence of exposure longitudinally. Methods: Data were ultilized from the 1997 and 2007 Australian National Surveys of Mental Health and Wellbeing. The 1997 survey assessed exposure using 11 items from the Composite International Diagnostic Interview (CIDI), version 2.1. The 2007 survey utilized 29 items from the World Mental Health CIDI. Prevalence rates of exposure to matched events among age-matched samples from both surveys were compared to determine whether differences in the estimates obtained were due to respondents having been asked about an increased number of event types in the latter survey. Results: The effect of increasing the number of event types in the CIDI from 11 to 29 was to increase the overall population prevalence of exposure to PTEs by 18%. The difference between estimates was more pronounced in women than in men. The cross-cohort analyses revealed that these differences were not indicative of an increase in trauma exposure over time; but rather the endorsement of new events that were not listed in the earlier survey. Conclusions: The findings underscore the importance of using comprehensive assessments in the measurement of exposure to PTEs. Previous epidemiological surveys may have underestimated the prevalence of traumatic and other stressful life events, particularly among women.
Tropical Cyclonic Rainfall in China: Changing Properties, Seasonality, and Causes

Using daily rainfall data from 1936 stations across China, this study investigated tropical cyclonic rainfall (TCR) changes during 1960–2014. The possible reasons behind TCR changes were examined using tracks and frequency of tropical cyclones (TCs) in both space and time. The highest annual TCR occur in coastal regions of east and southeast China (>500 mm/year). At monthly scale, August TCR can reach 150–250 mm in coastal regions. From the contribution viewpoint, TCR accounts for more than 40% of the monthly total rainfall and extreme rainfall events along the southeast coast of China. The contributions of TCR to the monthly rainfall amount decrease rapidly from coast to inland and are even faster for contributions of TCR to extreme rainfall. The distance inland from the shoreline with 250 km has been identified as the threshold, within that these contributions abruptly increase with decreasing distance from shoreline, and vice versa. In terms of extreme rainfall regimes, logistic and Poisson regressive techniques were used to identify the connections between TC‐induced extreme rainfall and El Niño–Southern Oscillation. Both these two regressions reveal that TC‐induced extreme rainfall tends to occur with higher frequency and magnitude in southeastern China (east and northeast coast of China) during La Niña (El Niño) years (El Niño). These consistent relations and remarkable spatial patterns can help to predict the occurrence of TC‐induced extreme rainfall events across eastern China.
Product customisation and manufacturing strategy

Reviews literature from manufacturing strategy, flexibility, agile manufacturing, and aspects of industrial marketing and highlights fragmented and inadequate treatment of fundamental issues relating to product customisation. Through synthesis of the literature and the analysis of four case studies – in the manufacture of fork‐lift trucks, electro‐mechanical devices, small telecommunications systems and stationery products respectively – presents a novel model of the customisation process. Identifies typologies of customisation problem‐solving situations and custom‐build option types. Demonstrates the importance of the relationship between the degree of design activity and volume of manufacture, and of the distinction between products that are custom‐built from options, and those that involve some custom‐designed elements. Proposes a range of potential roles for customised products to support management decision making in the selection of appropriate business activities.