Miracle-dz/UniFAR-FTUs huggingface dataset:
NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia

NPM1 mutations, causing aberrant cytoplasmic expression of nucleophosmin, are the most frequent genetic alteration in acute myeloid leukemia with a normal karyotype. This study confirms in a large series of patients that NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities. Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ acute myeloid leukemia) represents one-third of adult AML (50–60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, pathological and clinical features. We confirm in 2562 patients with acute myeloid leukemia our previous observation that NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities. Taken together, these findings make NPMc+ acute myeloid leukemia a good candidate for inclusion in the upcoming World Health Organization classification.
Comparison of EEG signal preprocessing methods for SSVEP recognition

This study was carried out to select EEG signal preprocessing methods to effectively detect and classify Steady State Visually Evoked Potentials (SSVEP). Algorithms, such as: Common Average Reference, Independent Component Analysis (in the task of electrooculography artifacts removing and SSVEP enhancement) and combinations of them were implemented and tested. The best classification accuracy improvement was obtained for CAR and ICA-SSVEP preprocessing methods. Experiments showed high usefulness of these methods in the context of SSVEP detection.
The Effects of Exercising in Different Natural Environments on Psycho-Physiological Outcomes in Post-Menopausal Women: A Simulation Study

The current study examined potential psycho-physiological benefits from exercising in simulated natural environments among a sample of post-menopausal women using a laboratory based protocol. Participants cycled on a stationary exercise bike for 15 min while facing either a blank wall (Control) or while watching one of three videos: Urban (Grey), Countryside (Green), Coast (Blue). Blood pressure, heart rate and affective responses were measured pre-post. Heart rate, affect, perceived exertion and time perception were also measured at 5, 10 and 15 min during exercise. Experience evaluation was measured at the end. Replicating most earlier findings, affective, but not physiological, outcomes were more positive for exercise in the simulated Green and, for the first time, Blue environment, compared to Control. Moreover, only the simulated Blue environment was associated with shorter perceived exercise duration than Control and participants were most willing to repeat exercise in the Blue setting. The current research extended earlier work by exploring the effects of “blue exercise” and by using a demographic with relatively low average levels of physical activity. That this sample of postmenopausal women were most willing to repeat a bout of exercise in a simulated Blue environment may be important for physical activity promotion in this cohort.
Progressive oxidation of cytoskeletal proteins and accumulation of denatured hemoglobin in stored red cells

Red blood cell (RBC) membrane proteins undergo progressive pathological alterations during storage. In conditions of increased cellular stress, the cytoskeleton also sustains certain modifications. The hemoglobin (Hb) content and oxidative status of the RBC cytoskeletons as a function of the storage period remain unclear. The possible Hb content and oxidative alterations occurring in the cytoskeletons in the course of storage were monitored in six units, by means of electrophoresis, immunoblotting and protein carbonylation assays. A proportion of the ghost‐bound Hb consists of non‐reducible crosslinkings of probably oxidized(denatured Hb or hemichromes.The defective Hb‐membrane association was strongly affected by the prolonged storage. A progressive accumulation of Hb monomers, multimers and high molecular weight aggregates to corresponding cytoskeletons were also evident. The oxidative index of the cytoskeletal proteins was found increased, signalizing oxidative modifications in spectrin and possibly other cytoskeletal proteins. The reported data corroborate the evidence for oxidative damage in membrane proteins with emphasis to the cytoskeletal components. They partially address the pathophysiological mechanisms underlying the RBC storage lesion, add some new insight in the field of RBC storage as a hemoglobin‐ and cytoskeleton‐associated pathology and suggest the possible use of antioxidants in the units intended for transfusion.
Photovoice: Exploring the Role of Teacher’s Question for University Students’ Fluency in Speaking Class

Abstract. Speaking skill is essential in language learning and teaching process because the goal of learning a foreign language is to be able to communicate using the target language. Fluency is one of the leading criteria that the students should accomplish in speaking skill. However, most of EFL students tend to be more nervous if they speak English, and this will impact their fluency. The objective of the research is to investigate how questioning gives an impact for students’ fluency in academic speaking class. The researchers used narrative inquiry to collect and process the data using Photovoice. The participants of this research were 12 university students. The finding shows that the use of questioning can develop students’ speaking fluency in academic speaking class. As the implication, teachers can give questions followed with feedback to enhance the students’ fluency. Keywords : fluency, speaking skill, questioning, photovoice.
On the Aubry–Mather theory for symbolic dynamics

Abstract We propose a new model of ergodic optimization for expanding dynamical systems: the holonomic setting. In fact, we introduce an extension of the standard model used in this theory. The formulation we consider here is quite natural if one wants a meaning for possible variations of a real trajectory under the forward shift. In other contexts (for twist maps, for instance), this property appears in a crucial way. A version of the Aubry–Mather theory for symbolic dynamics is introduced. We are mainly interested here in problems related to the properties of maximizing probabilities for the two-sided shift. Under the transitive hypothesis, we show the existence of sub-actions for Hölder potentials also in the holonomic setting. We analyze then connections between calibrated sub-actions and the Mañé potential. A representation formula for calibrated sub-actions is presented, which drives us naturally to a classification theorem for these sub-actions. We also investigate properties of the support of maximizing probabilities.
High-Performance Multi-Level Routing

Shortest-path computation is a frequent task in practice. Owing to ever-growing real-world graphs, there is a constant need for faster algo- rithms. In the course of time, a large number of techniques to heuristically speed up Dijkstra's shortest-path algorithm have been devised. This work re- views the multi-level technique to answer shortest-path queries exactly (24, 9), which makes use of a hierarchical decomposition of the input graph and pre- computation of supplementary information. We develop this preprocessing to the maximum and introduce several ideas to enhance this approach consider- ably, by reorganizing the precomputed data in partial graphs and optimizing them individually. To answer a given query, certain partial graphs are combined to a search graph, which can be explored by a simple and fast procedure. The concept behind the construction of the search graph is such that query times depend mainly on the number of partial graphs included. This is confirmed by ex- periments with different road graphs, each containing several million vertices, and time, distance, and unit metrics. Our query algorithm computes the dis- tance between any pair of vertices in no more than 40 µs, however, a lengthy preprocessing is required to achieve this query performance.
Salience effect on the processing of idioms in L1: Evidence from Malay Simpulan Bahasa

Experimental investigations into figurative language processing have received little attention for languages other than English and several major European languages. Research on the Malay language, in particular, has been very limited. This study thus aimed to investigate the figurative language processing of familiar Malay idioms by L1 native speakers. Familiarity or salience is hypothesised as having a dominating effect in the processing of idiom meaning. This means, regardless of context or other possible factors, salience is said to determine processing advantage. A total of 24 participants completed a timed lexical-decision task after listening to idiomatic stimuli. Eight highly familiar idioms embedded in neutral sentences were used as auditory stimuli, and were paired visually together with either their figurative or literal meaning as target words. Results revealed a similar processing speed for responses to both literal and idiomatic meanings. Hence, it was concluded that the salience levels of both meanings are balanced in line with the Graded Salience Hypothesis.
Predicting an observer's task using multi-fixation pattern analysis

Since Yarbus's seminal work in 1965, vision scientists have argued that people's eye movement patterns differ depending upon their task. This suggests that we may be able to infer a person's task (or mental state) from their eye movements alone. Recently, this was attempted by Greene et al. [2012] in a Yarbus-like replication study; however, they were unable to successfully predict the task given to their observer. We reanalyze their data, and show that by using more powerful algorithms it is possible to predict the observer's task. We also used our algorithms to infer the image being viewed by an observer and their identity. More generally, we show how off-the-shelf algorithms from machine learning can be used to make inferences from an observer's eye movements, using an approach we call Multi-Fixation Pattern Analysis (MFPA).
Lines of School-University Partnership: Perception, Sensation and Meshwork Reshaping Of Pre-Service Teachers’ Experiences

School-university partnerships are complex, entangled and layered. As renewal of initial teacher education is at the forefront, understanding how we approach partnerships is imperative. This paper draws on reflective narratives of a school leader and initial teacher education staff involved in setting up a school-university partnership program. We identify the use of ‘meshworks’, that is complex and layered weaving of ideas or lines (Ingold, 2011; 2015; 2017) – specifically the lines of ‘partnership’, ‘partnership understanding’, ‘involvement’, ‘supporting pre-service teachers’, ‘noticing of pre-service teachers’, and ‘impact’. The analysis of the findings illuminate benefits from co-design and vision, while demonstrating how a call to action from Australian Institute for Teaching and School Leadership (AITSL) can illuminate how working closely together can support the development of pre-service teachers. We conclude by suggesting that future teacher quality is dependent upon the strength of the intersections of these school-university partnerships.
INFLUENCE OF PERSON-ORGANISATION-FIT ON WORK ENGAGEMENT THROUGH ENHANCED JOB SATISFACTION: TEST OF SOCIAL IDENTITY THEORY

This study extends Social Identity Theory by examining the link between Person-Organisation fit (POF) and Work Engagement (WE) through enhanced Job Satisfaction (JS) and testing it in a non-US environment. The study was conducted on a large sample (527) of Turkish blue and white-collar employees from business units of 15 independent companies; 10 different industry types. Data was analysed with Structural Equation Modelling. It was found that POF was positively related to WE, and secondly Job Satisfaction (JS) was (positively) related to WE. Results also showed that job satisfaction acted as a mediator between POF and WE and it mediated as high as 70 % of the effect of POFs. This study supports the research stream that JS was a predictor of work engagement. The results confirmed the applicability of Social Identity Theory in a Turkish context and advocates that employees who fit to organisation more are more likely to have job satisfaction and repay this to the organisation through higher levels of engagement.
Multiobjective Virtual Machine Placement in Cloud Environment

In this paper, the virtual machine placement problem is formulated as a multi-objective optimization problem. The objectives are maximizing profit, maximizing load balancing and minimizing recourse wastage. Results of Genetic algorithms, Non-dominated Sorting Genetic Algorithm and Non-dominated Sorting Genetic Algorithm-II are compared with common solution representation, penalty and benefit values. All the three algorithms reported good solutions whereas GA and NSGA are subjected to premature convergence and duplicate solutions. NSGA-II gives good and diversified range of solutions.
Alteration of Pituitary Tumor Transforming Gene-1 Regulates Trophoblast Invasion via the Integrin/Rho-Family Signaling Pathway

Trophoblast invasion ability is an important factor in early implantation and placental development. Recently, pituitary tumor transforming gene 1 (PTTG1) was shown to be involved in invasion and proliferation of cancer. However, the role of PTTG1 in trophoblast invasion remains unknown. Thus, in this study we analyzed PTTG1 expression in trophoblasts and its effect on trophoblast invasion activity and determined the mechanism through which PTTG1 regulates trophoblast invasion. Trophoblast proliferation and invasion abilities, regardless of PTTG1 expression, were analyzed by quantitative real-time polymerase chain reaction, fluorescence-activated cell sorting analysis, invasion assay, western blot, and zymography after treatment with small interfering RNA against PTTG1 (siPTTG1). Additionally, integrin/Rho-family signaling in trophoblasts by PTTG1 alteration was analyzed. Furthermore, the effect of PTTG1 on trophoblast invasion was evaluated by microRNA (miRNA) mimic and inhibitor treatment. Trophoblast invasion was significantly reduced through decreased matrix metalloproteinase (MMP)-2 and MMP-9 expression when PTTG1 expression was inhibited by siPTTG1 (p < 0.05). Furthermore, knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased (p < 0.05). Treatment of miRNA-186-5p mimic and inhibitor controlled trophoblast invasion ability by altering PTTG1 and MMP expression. PTTG1 can control trophoblast invasion ability via regulation of MMP expression through integrin/Rho-family signaling. In addition, PTTG1 expression and its function were regulated by miRNA-186-5p. These results help in understanding the mechanism through which PTTG1 regulates trophoblast invasion and thereby implantation and placental development.
Accelerometry-Based Home Monitoring for Detection of Nocturnal Hypermotor Seizures Based on Novelty Detection

Nocturnal home monitoring of epileptic children is often not feasible due to the cumbersome manner of seizure monitoring with the standard method of video/EEG-monitoring. We propose a method for hypermotor seizure detection based on accelerometers attached to the extremities. From the acceleration signals, multiple temporal, frequency, and wavelet-based features are extracted. After determining the features with the highest discriminative power, we classify movement events in epileptic and nonepileptic movements. This classification is only based on a nonparametric estimate of the probability density function of normal movements. Such approach allows us to build patient-specific models to classify movement data without the need for seizure data that are rarely available. If, in the test phase, the probability of a data point (event) is lower than a threshold, this event is considered to be an epileptic seizure; otherwise, it is considered as a normal nocturnal movement event. The mean performance over seven patients gives a sensitivity of 95.24% and a positive predictive value of 60.04%. However, there is a noticeable interpatient difference.
Influence of GaN cap on robustness of AlGaN/GaN HEMTs

DC-Step-Stress-Tests of GaN HEMTs have been performed on wafers with and without GaN-cap. The tests consist of a step ramping of drain-source voltage VDS by 5V every two hours at off-state. The irreversible evolution of leakage current starting at a certain drain voltage has been taken as a criterion for the onset of device degradation. It has been stated that there is a stability limit for VDS depending on the epitaxial design. It has been found that wafers with GaN cap show much higher critical voltages as compared to non-capped epitaxial designs. Electroluminescence measurements have been performed to localize defects after DC-Step-Stress-Tests up to 80V for wafer without GaN cap and 120V for wafer with GaN cap.
MARKET ORIENTATION VS OTHER BUSINESS APPROACHES , AND THEIR RELATIONSHIP WITH PROFITABILITY

Marketing theory has traditionally contrasted a market orientation to internally oriented approaches stressing productive efficiency, or selling and promoting. This study examines the comparative effect of these three different emphases on profit performance. The results indicate that analysis of customer needs has a positive association with profitability. Internally oriented approaches do not have a positive association with profitability.
X-ray emission from T Tauri stars and the role of accretion: inferences from the XMM-Newton extended survey of the Taurus molecular cloud

Context. T Tau stars display di erent X-ray properties depending on whether they are accreting (classical T Tau stars; CTTS) or not (weak-line T Tau stars; WTTS). X-ray properties may provide insight into the accretion process between disk and stellar surface. Aims. We use data from the XMM-Newton Extended Survey of the Taurus Molecular Cloud (XEST) to study di erences in X-ray properties between CTTS and WTTS. Methods. XEST data are used to perform correlation and regression analysis between X-ray parameters and stellar properties. Results. We confirm the existence of a X-ray luminosity (LX) vs. mass (M) relation, LX/ M 1:69 0:11 , but this relation is a consequence of X-ray saturation and a mass vs. bolometric luminosity (L ) relation for the TTS with an average age of 2.4 Myr. X-ray saturation indicates LX= constL , although the constant is di erent for the two subsamples: const= 10 3:73 0:05 for CTTS and const= 10 3:39 0:06 for WTTS. Given a similar L distribution of both samples, the X-ray luminosity function also reflects a real X-ray deficiency in CTTS, by a factor of 2 compared to WTTS. The average electron temperatures Tav are correlated with LX in WTTS but not in CTTS; CTTS sources are on average hotter than WTTS sources. At best marginal dependencies are found between X-ray properties and mass accretion rates or age. Conclusions. The most fundamental properties are the two saturation laws, indicating suppressed LX for CTTS. We speculate that some of the accreting material in CTTS is cooling active regions to temperatures that may not significantly emit in the X-ray band, and if they do, high-resolution spectroscopy may be required to identify lines formed in such plasma, while CCD cameras do not detect these components. The similarity of the LX vs. Tav dependencies in WTTS and main-sequence stars as well as their similar X-ray saturation laws suggests similar physical processes for the hot plasma, i.e., heating and radiation of a magnetic corona.
Morphology control via dual solvent crystallization for high-mobility functionalized pentacene-blend thin film transistors

We present an approach to improving the performance of solution processed organic semiconductor transistors based on a dual solvent system. We here apply this to a blend containing the π-conjugated small molecule 6,13 bis(triisopropylsilylethynyl) pentacene (TIPS-pentacene) and polystyrene, which acts as an inert binder. Using a semiconductor-binder solution of two solvents, where the main solvent is a better solvent of the small molecule and second solvent is a better solvent of the polymer, crystal morphologies can be altered and transistor mobilities increased by almost an order of magnitude. In this way, air-ambient and solution-processed transistors with linear and saturation mobilities higher than 1 cm2 V−1s−1 have been fabricated. We discuss how the solubility properties of the formulation components can be used to identify solvent candidates that promote an efficient self-assembly of the small molecule.
Performance of Residual Carrier Array-Feed Combining in Correlated Noise

An array feed combining system for the recovery of signal-to-noise ratio (SNR) lass due to antenna reflector deformation has been implemented and is currently being evaluated on the Jet Propulsion Laboratory's 34-meter DSS-13 antenna. In th& system, the defocused signal field captured by a focal plane array feed is recovered using real-time signal-processing and signal-combining techniques. The current signal-processing and signal-combining algorithms are optimum under the assumption that the white Gaussian noise processes in the received signals from different array elements are mutually uncorrelated. Experimental data at DSS 13 indicate that these noise processes are indeed mutually correlated. The main result of this article is an analytical derivation of the actual SNR performance of the current suboptimal signal-combining algorithm in this correlated-noise environment. The analysis here shows that the combined signal SNR can either be improved or degraded depending on the relation between the array signal and noise correlation coet_cient phases. Further performance improvement will require the development of signal-combining methods that take into account the correlated noises. We consider the problem of finding a trellis for a linear block code that minimizes one or more measures of trellis complexity for a fixed permutation o[ the code. We examine constraints on trellises, including relationships between the minimal trellis of a code and that of the dual code. We identify the primitive structures that can appear in a minimal trellis and relate this to those for the minimal trellis of the dual code.
The Collatz conjecture. A case study in mathematical problem solving

In previous papers (see Van Bendegem [1993], [1996], [1998], [2000], [2004], [2005], and jointly with Van Kerkhove [2005]) we have proposed the idea that, if we look at what mathematicians do in their daily work, one will find that conceiving and writing down proofs does not fully capture their activity. In other words, it is of course true that mathematicians spend lots of time proving theorems, but at the same time they also spend lots of time preparing the ground, if you like, to construct a proof.