Miracle-dz/UniFAR-FTUs huggingface dataset:
Personality and Self-Perceptions of Creativity across Domains

The current study evaluated the structure of a revised (shortened) version of the Creativity Domain Questionnaire (CDQ), examined its relationship with five personality factors, and analyzed potential differences in creativity domains based upon gender and occupational status. One hundred eighty-two students and 60 warehouse employees completed the Revised Creativity Domain Questionnaire (CDQ-R) and the Big Five Factor Markers. Consistent with an exploratory factor analysis of pilot data, a subsequent confirmatory factor analysis of these data supported a four-factor structure for the CDQ-R. Correlations between these four creativity domains and the Big Five personality factors generally were consistent with theoretical expectations. Effects for gender also were consistent with theory. Women perceived themselves as more creative in the Arts general domain while men perceived themselves significantly more creative in Math/Science. There were no effects for occupational status. Creativity takes place in diverse contexts, and we cannot expect the personalities of people who create in different domains to be the same, or to differ in the same ways from comparison subjects. (Helson, 1996, p. 303)
Remembering what we do, not what we view: The plasticity of everyday cognitive maps

When we examine a town map or view the town from a height we obtain survey knowledge, knowledge of the spatial configuration. When we navigate through the town we acquire procedural knowledge, knowledge about how our route connects different locations in the town. Three experiments investigated whether everyday cognitive maps formed after repeated navigation are primarily configurational or procedural when both configurational and procedural information on the routes travelled are available. If such maps are procedural then arguably they can be markedly inaccurate and lead to incorrect direction giving. The three experiments focussed on direction and location errors associated with constructing cognitive maps of routes from a town to a nearby university. Experiment 1 (N = 157), carried out when only one route was available, found that the distribution of the relative locations of the start and end points of the route from a frequentlynavigate-group's maps was markedly bimodal, including a large subset of .
Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules.

The cystine knot three-dimensional structure is found in many extracellular molecules and is conserved among divergent species. The identification of proteins with a cystine knot structure is difficult by commonly used pairwise alignments because the sequence homology among these proteins is low. Taking advantage of complete genome sequences in diverse organisms, we used a complementary approach of pattern searches and pairwise alignments to screen the predicted protein sequences of five model species (human, fly, worm, slime mold, and yeast) and retrieved proteins with low sequence homology but containing a typical cystine knot signature. Sequence comparison between proteins known to have a cystine knot three-dimensional structure (transforming growth factor-beta, glycoprotein hormone, and platelet-derived growth factor subfamily members) identified new crucial amino acid residues (two hydrophilic amino acid residues flanking cysteine 5 of the cystine knot). In addition to the well known members of the cystine knot superfamily, novel subfamilies of proteins (mucins, norrie disease protein, von Willebrand factor, bone morphogenetic protein antagonists, and slit-like proteins) were identified as putative cystine knot-containing proteins. Phylogenetic analysis revealed the ancient evolution of these proteins and the relationship between hormones [e.g. transforming growth factor-beta (TGFbeta)] and extracellular matrix proteins (e.g. mucins). They are absent in the unicellular yeast genome but present in nematode, fly, and higher species, indicating that the cystine knot structure evolved in extracellular signaling molecules of multicellular organisms. All data retrieved by this study can be viewed at http://hormone.stanford. edu/.
Extensive SEU Impact Analysis of a PIC Microprocessor for Selective Hardening

In order to increase the robustness of a circuit against SEUs, fault injection is commonly used to locate weak areas. autonomous emulation is a very powerful tool to locate these areas by executing huge fault injection campaigns. In this work, fault injection has been extensively applied to a PIC18 microprocessor, while executing three different workloads. A 80 million fault campaign has been performed, and results show that a failure rate lower than 1% can be obtained by hardening a 24% of the circuit flip-flops, for the given applications.
Improving Educational Outcomes of Hispanic Students in a Professional Degree Program

In an attempt to reduce the educational achievement gap of Hispanic students in a professional degree program, two courses grounded in the Keller method were implemented at a pharmacy school. The Keller method is characterized by breaking course content into modules, then allowing students to test and repeatedly remediate and retest until competency is achieved. Outcomes from this intervention-based cohort study suggest that the Keller method is effective in reducing the educational achievement gap of Hispanic students in a professional degree program.
Managing Global Virtual Teams: an Exploration of Operation and Performance

As Global Virtual Teams (GVTs) operate across diverse geographies, time-zones, and cultures, they present particular problems for project management in that their characteristics may negatively affect team performance. While a significant body of research exists on project management and GVTs, previous studies have not fully elaborated on the collective impact that GVT characteristics, such as temporal distance and geographical distance, etc., have on operation and performance. This paper develops a conceptual model from existing research and generates hypotheses to explore the impact of GVT characteristics on team operations and performance. The model is then applied in a broad survey of software developers participating in GVTs. Significantly; the study found that different GVT characteristics contribute to (i) GVT operational problems and (ii) negatively impact team performance. These findings have important implications for research and GVT practitioners’ ability to operate such teams and ensure desired project outcomes.
How music touches: Musical parameters and listeners’ audio-tactile metaphorical mappings

Though the relationship of touch and sound is central to music performance, and audio-tactile metaphors are pertinent to musical discourse, few empirical studies have investigated systematically how musical parameters such as pitch height, loudness, timbre and their interactions affect auditory–tactile metaphorical mappings. In this study, 40 participants (20 musically trained) rated the appropriateness of six dichotomous tactile metaphors (sharp–blunt, smooth–rough, soft–hard, light–heavy, warm–cold and wet–dry) to 20 sounds varying in pitch height, loudness, instrumental timbre (violin vs. flute) and vibrato. Results (repeated measures MANOVA) suggest that tactile metaphors are strongly associated with all musical variables examined. For instance, higher pitches were rated as significantly sharper, rougher, harder, colder, drier and lighter than lower pitches. We consider several complementary accounts of the findings: psychophysical analogies between tactile and auditory sensory processing; experiential analogies, based on correlations between tactile and auditory qualities of sound sources in daily experience; and analogies based on abstract semantic dimensions, particularly potency and activity.
Operationalising children's rights: lessons from research

This article considers ways in which the implementation of children's rights can be measured in law, policy and practice. It identifies best practice and lessons to be learnt when undertaking the process of auditing the implementation of children's rights. It draws on the author's experience of four different research projects whose task was to measure the extent to which children's rights were being protected and promoted. The article highlights the value of rights‐based research, which attempts to operationalise children's rights by measuring their practical implementation with regard to international standards including the Convention on the Rights of the Child (CRC). It sets out the lessons to be learnt from such research, including how to develop appropriate and effective benchmarks, how to maximise existing standards to this end, and how to apply them in line with the general principles of the CRC.
The Pseudomonas syringae type III‐secreted protein HopPtoD2 possesses protein tyrosine phosphatase activity and suppresses programmed cell death in plants

The bacterial plant pathogen Pseudomonas syringae possesses a type III protein secretion system that delivers many virulence proteins into plant cells. A subset of these proteins (called Avr proteins) is recognized by the plant's innate immune system and triggers defences. One defence‐associated response is the hypersensitive response (HR), a programmed cell death (PCD) of plant tissue. We have previously identified HopPtoD2 as a type III secreted protein from P. s. pv. tomato DC3000. Sequence analysis revealed that an N‐terminal domain shared homology with AvrPphD and a C‐terminal domain was similar to protein tyrosine phosphatases (PTPs). We demonstrated that purified HopPtoD2 possessed PTP activity and this activity required a conserved catalytic Cys residue (Cys378). Interestingly, HopPtoD2 was capable of suppressing the HR elicited by an avirulent P. syringae strain on Nicotiana benthamiana. HopPtoD2 derivatives that lacked Cys378 no longer suppressed the HR indicating that HR suppression required PTP activity. A constitutively active MAPK kinase, called NtMEK2DD, is capable of eliciting an HR‐like cell death when transiently expressed in tobacco. When NtMEK2DD and HopPtoD2 were co‐delivered into plant cells, the HR was suppressed indicating that HopPtoD2 acts downstream of NtMEK2DD. DC3000 hopPtoD2 mutants were slightly reduced in their ability to multiply in planta and displayed an enhanced ability to elicit an HR. The identification of HopPtoD2 as a PTP and a PCD suppressor suggests that the inactivation of MAPK pathways is a virulence strategy utilized by bacterial plant pathogens.
Reaching Time Estimation for “Super-Twisting” Second Order Sliding Mode Controller via Lyapunov Function Designing

A method of a Lyapunov functions design based on resolving of the first-order partial differential equation of a special type is presented. A successful resolution of this equation guaranties a finite-time convergence for the corresponding dynamics given by an ordinary differential equation with a discontinuous right-hand side. It is also provides an analytical formula for an upper bound of the corresponding reaching time. The suggested method is applied to the problem of a stability analysis and a reaching time estimation of the, so-called, ldquosuper-twistingrdquo controller. The estimation accuracy is confirmed by numerical example.
The effects of music relaxation and muscle relaxation techniques on sleep quality and emotional measures among individuals with posttraumatic stress disorder

Posttraumatic stress disorder (PTSD), an anxiety disorder with lifetime prevalence of 7.8%, is characterized by symptoms that develop following exposure to traumatic life events and that cause an immediate experience of intense fear, helplessness or horror. PTSD is marked by recurrent nightmares typified by the recall of intrusive experiences and by extended disturbance throughout sleep. Individuals with PTSD respond poorly to drug treatments for insomnia. The disadvantages of drug treatment for insomnia underline the importance of non-pharmacological alternatives. Thus, the present study had three aims: first, to compare the efficiency of two relaxation techniques (muscular relaxation and progressive music relaxation) in alleviating insomnia among individuals with PTSD using both objective and subjective measures of sleep quality; second, to examine whether these two techniques have different effects on psychological indicators of PTSD, such as depression and anxiety; and finally, to examine how initial PTSD symptom severity and baseline emotional measures are related to the efficiency of these two relaxation methods. Thirteen PTSD patients with no other major psychiatric or neurological disorders participated in the study. The study comprised one seven-day running-in, no-treatment period, followed by two seven-day experimental periods. The treatments constituted either music relaxation or muscle relaxation techniques at desired bedtime. These treatments were randomly assigned. During each of these three experimental periods, subjects' sleep was continuously monitored with a wrist actigraph (Ambulatory Monitoring, Inc.), and subjects were asked to fill out several questionnaires concerned with a wide spectrum of issues, such as sleep, depression, and anxiety. Analyses revealed a significant increase in objective and subjective sleep efficiency and a significant reduction in depression level following music relaxation. Moreover, following music relaxation, a highly significant negative correlation was found between improvement in objective sleep efficiency and reduction in depression scale. The study's findings provide evidence that music relaxation at bedtime can be used as treatment for insomnia among individuals with PTSD.
Focal Brain Lesions to Critical Locations Cause Widespread Disruption of the Modular Organization of the Brain

Although it is generally assumed that brain damage predominantly affects only the function of the damaged region, here we show that focal damage to critical locations causes disruption of network organization throughout the brain. Using resting state fMRI, we assessed whole-brain network structure in patients with focal brain lesions. Only damage to those brain regions important for communication between subnetworks (e.g., “connectors”)—but not to those brain regions important for communication within sub-networks (e.g., “hubs”)—led to decreases in modularity, a measure of the integrity of network organization. Critically, this network dysfunction extended into the structurally intact hemisphere. Thus, focal brain damage can have a widespread, nonlocal impact on brain network organization when there is damage to regions important for the communication between networks. These findings fundamentally revise our understanding of the remote effects of focal brain damage and may explain numerous puzzling cases of functional deficits that are observed following brain injury.
MMPI-2 Variables in Attention and Memory Test Performance.

Attention span (Digit Span), verbal list learning, and memory test performance (Wechsler Memory Scale—Revised; WMS-R) were examined in relation to Minnesota Multiphasic Personality Inventory—2 (MMPI-2) measures of depression, anxiety, and psychotic thinking in male patients with closed-head injury (« = 48) and with psychiatric disorder (n = 80). In both samples, MMPI-2 scores were significantly related to Attention Span but independent of List Learning performance. MMPI-2 scores correlated with factor scores derived from the Logical Memory and Visual Reproduction subtests of the WMS-R. The results of a hierarchical regression analysis, which examined the relative effects of neurologic and emotional status, support the view that MMPI-2 scores are relevant to the interpretation of performance on neuropsychological tests of attention and memory. The potential influence of emotional factors on cognitive functioning has been a continuing area of concern in neuropsychological assessment. It is widely recognized that problems such as anxiety, depression, and psychotic thinking can adversely affect neuropsychological test performance and cognitive efficiency in daily living (Burt, Zembar, & Niederehe, 1995; Rabins, Pearlson, & Strauss, 1993). The Minnesota Multiphasic Personality Inventory—2 (MMPI-2), which is the most widely used measure of psychopathology in neuropsychological and general medical settings, ostensibly measures these and other emotional factors. Several investigators reported Halstead-Reitan Battery scores to be independent of MMPI scores, supporting the view that standardized test batteries may be fairly resilient to the effects of psychological disturbance (Calsyn, Louks, & Johnson, 1982; Gass, 1991; Heaton, Baade, & Johnson, 1978; Heaton & Crowley, 1981; Reitan & Wolfson, 1993). However, little is known regarding the MMPI-2 and the manner in which its scores may be related to performance on other widely used neuropsychological tests. In the present study, it was hypothesized that scores on MMPI-2 scales related to depression (D and DEP), anxiety (Ft, ANX, FRS, and OBS), and psychotic thinking (Sc and BIZ) would show a negative association with performance on measures of attention, retentive memory, and acquisition of verbal list material. In addition, this study examined the relative importance of closed-head injury and emotional factors as measured by the MMPI-2 in interpreting cognitive test performance.
Creating a Culture of Self-Care

Psychologists are vulnerable to the effects of distress, which if left unchecked may lead to burnout, vicarious traumatization, and impaired professional competence. Smith and Moss (2009) provide a convincing call to action for the profession of psychology to give adequate attention to these important issues. This commentary adds to their excellent review and provides specific recommendations for individual psychologists for those who train graduate students, and for professional associations. A rationale is provided for the recommendations made and further guidance is provided for creating a culture of self-care in the profession of psychology. The importance of this approach as an ethical imperative is presented and strategies and recommendations are provided.
Early-life antibiotic use is associated with wheezing among children with high atopic risk: a prospective European study

Abstract Background: Little is known about the relationship between antibiotic use and asthma in the children with a higher risk of allergic sensitization. We examine the association between the use of specific therapeutic antibiotics in the first year of life and development of wheezing by 36 months among children with a higher risk of allergic sensitization. Methods: A multi-center prospective cohort study was conducted among children at high risk for allergic sensitization. A validated questionnaire was used to prospectively collect information on antibiotic use and potential risk factors for wheezing from parents or guardians of 606 children from three European countries at 6, 12, 24 and 36 months of age. Multivariate linear and logistic regression models were used to adjust for potential confounders and effect modifiers and to estimate the association of antibiotic use with the development of early childhood wheezing. Results: Of the antibiotics assessed, only macrolide use in the first year of life was associated with increasing risk for wheezing by 36 months, after adjusting for gender, socioeconomic status, breast feeding >6 months, tobacco smoke exposure, family history of asthma, and respiratory infection (RR = 1.09; 95% CI 1.05–1.13). To avoid a bias by indication, we analyzed children with and without respiratory infection separately. Similar associations were observed for macrolides use in children who had no respiratory infection. Conclusions: In European children with a familial risk for allergic sensitization, we found a positive association between macrolide use in the first year of life and wheezing until 36 months old which was independent of the effect of respiratory infection.
T-817MA, but Not Haloperidol and Risperidone, Restores Parvalbumin-Positive γ-Aminobutyric Acid Neurons in the Prefrontal Cortex and Hippocampus of Rats Transiently Exposed to MK-801 at the Neonatal Period

The number of parvalbumin (PV)-positive γ-aminobutyric acid (GABA) neurons is decreased in the brain of rats transiently exposed to MK-801, an N-methyl-D-aspartate (NMDA) receptor blocker, in the neonatal stage (Uehara et al. (2012)). T-817MA [1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate] is a neuroprotective agent synthesized for the treatment of psychiatric disorders characterized by cognitive disturbances, such as dementia. We herein sought to determine whether T-817MA, haloperidol (HPD), or risperidone (RPD) would ameliorate the decrease in the number of PV-positive GABA neurons in the medial prefrontal cortex (mPFC) and hippocampus of the model animals. Rats were treated with MK-801 (0.2 mg/kg/day) or vehicle on postnatal days (PD) 7–10, and the number of PV-positive neurons in the mPFC and hippocampus were measured on PDs 63. T-817MA (20 mg/kg), HPD (1 mg/kg), or RPD (1 mg/kg) were administered during PDs 49–62. Fourteen-day administration of T-817MA reversed the decrease in the number of PV-positive neurons in the above brain regions of rats given MK-801, whereas HPD and RPD were ineffective. These results indicate that T-817MA provides a novel pharmacologic strategy to enhance cognitive function in patients with schizophrenia.
Saccharomyces cerevisiae C-Type Cyclin Ume3p/Srb11p Is Required for Efficient Induction and Execution of Meiotic Development

ABSTRACT The yeast C-type cyclin Ume3p/Srb11p and its cyclin-dependent kinase partner Ume5p/Srb10p repress the transcription of several genes required for meiotic recombination or meiosis I nuclear division. To relieve this repression, Srb11p is destroyed early in meiosis, prior to the first meiotic division. This report identifies two roles for Srb11p in regulating meiotic development. First, SRB11 is required for the normal exit from the mitotic cell cycle prior to meiotic induction. Specifically, mutants lacking SRB11 (srb11Δ) uncouple bud growth from chromosome segregation, producing small buds with nuclei. The bud growth defect is most likely due to the failure of srb11Δ mutants to reestablish polarized actin fibers at the bud tip following exposure to sporulation medium. Second, Srb11p is required for the efficient execution of meiosis I. srb11Δ mutants either exhibited a delay in performing meiosis I and meiosis II or skipped meiosis I entirely. This meiotic defect is not due to the activation of the recombination or spindle assembly checkpoint pathways. However, the expression of several meiotic genes is delayed and reduced in the mutant strains. These results suggest a positive role for Srb10-Srb11p in regulating the transcription program. This model is supported by the finding that overexpression of the meiotic inducer IME2 partially restored the ability of srb11 mutants to perform meiosis I. In conclusion, these findings indicate that Srb11p is required for both entry into and execution of the meiotic program, thus describing multiple roles for a C-type cyclin in the regulation of a developmental pathway.