Miracle-dz/UniFAR-FTUs huggingface dataset:
Is there evidence for neuropsychological and neurobehavioral phenotypes among adults without FXTAS who carry the FMR1 premutation? A review of current literature

Abstract: Carriers of expanded, but unmethylated, premutation alleles of the fragile X mental retardation gene are at risk for a late-onset tremor/ataxia syndrome, mostly affecting men over age 50. However, the general neuropsychological and neurobehavioral impact of carrying a premutation allele in younger adults not affected by the tremor/ataxia syndrome remains unclear. Past studies have utilized varying study designs resulting in inconsistent conclusions. To better understand the current evidence of the influence of the premutation on such traits in adult carriers, we reviewed the literature and identified 16 studies that met conservative inclusion criteria, including molecular measures of the fragile X mental retardation gene CGG triplet repeat length and standard measures of neurobehavioral and neurocognitive phenotypes. A review of these studies is presented to assess the evidence for possible premutation-associated neuropsychological deficits among adult men and women who do not meet diagnostic criteria of the tremor/ataxia syndrome. Results of these studies, and possible reasons for inconsistent conclusions, are discussed. The primary conclusion from this review is the need for further research using a standard protocol in a large multisite project to ensure the necessary sample size.
Muscle-based tissue engineering for the musculoskeletal system

A simple, rapid, efficient and inexpensive process for on-site recycling of wastewater with minimal odor wherein the solid wastes generated by the water treatment process are dewatering on-site by solar energy to water content levels below those required for disposal. All operations, including solar dewatering, are accomplished in a compact unit which may be mobile. The solar dewatering unit includes a drying pan over which a solar collector window arrangement is disposed. In the process, wastewater, a water purifying composition and an oxidizing agent are additively mixed together in a first reactor settling tank and the resulting composition is neutralized to a pH of between 7.5-9.4. The added water purifying composition is then allowed to precipitate wherein it binds to and precipitates heavy metals as well as other impurities. The precipitated purifying composition forms a non-hazardous sludge at the bottom of the tank. The resulting supernatant is pumped through a filter to yield recycled wastewater suitable for disposal or reuse. The remaining sludge is pumped to a third tank where it is accumulated and thickened. Once a sufficient amount of sludge is accumulated, the sludge is pumped to a solar dewatering unit where the sludge is dried to a water content level below 50% water which is suitable for landfill disposal.
Determinants of Flow-Mediated Outward Remodeling in Female Rodents: Respective Roles of Age, Estrogens, and Timing

Objective—Flow (shear stress)-mediated outward remodeling (FMR) of resistance arteries is a key adaptive process allowing collateral growth after arterial occlusion but declining with age. 17-&bgr;-estradiol (E2) has a key role in this process through activation of estrogen receptor &agr; (ER&agr;). Thus, we investigated the impact of age and timing for estrogen efficacy on FMR. Approach and Results—Female rats, 3 to 18 months old, were submitted to surgery to increase blood flow locally in 1 mesenteric artery in vivo. High-flow and normal-flow arteries were collected 2 weeks later for in vitro analysis. Diameter increased by 27% in high-flow arteries compared with normal-flow arteries in 3-month-old rats. The amplitude of remodeling declined with age (12% in 18-month-old rats) in parallel with E2 blood level and E2 substitution failed restoring remodeling in 18-month-old rats. Ovariectomy of 3-, 9-, and 12-month-old rats abolished FMR, which was restored by immediate E2 replacement. Nevertheless, this effect of E2 was absent 9 months after ovariectomy. In this latter group, ER&agr; and endothelial nitric oxide synthase expression were reduced by half compared with age-matched rats recently ovariectomized. FMR did not occur in ER&agr;−/− mice, whereas it was decreased by 50% in ER&agr;+/− mice, emphasizing the importance of gene dosage in high-flow remodeling. Conclusions—E2 deprivation, rather than age, leads to decline in FMR, which can be prevented by early exogenous E2. However, delayed E2 replacement was ineffective on FMR, underlining the importance of timing of this estrogen action.
Sensorimotor Integration in Dyslexic Children under Different Sensory Stimulations

Dyslexic children, besides difficulties in mastering literacy, also show poor postural control that might be related to how sensory cues coming from different sensory channels are integrated into proper motor activity. Therefore, the aim of this study was to examine the relationship between sensory information and body sway, with visual and somatosensory information manipulated independent and concurrently, in dyslexic children. Thirty dyslexic and 30 non-dyslexic children were asked to stand as still as possible inside of a moving room either with eyes closed or open and either lightly touching a moveable surface or not for 60 seconds under five experimental conditions: (1) no vision and no touch; (2) moving room; (3) moving bar; (4) moving room and stationary touch; and (5) stationary room and moving bar. Body sway magnitude and the relationship between room/bar movement and body sway were examined. Results showed that dyslexic children swayed more than non-dyslexic children in all sensory condition. Moreover, in those trials with conflicting vision and touch manipulation, dyslexic children swayed less coherent with the stimulus manipulation compared to non-dyslexic children. Finally, dyslexic children showed higher body sway variability and applied higher force while touching the bar compared to non-dyslexic children. Based upon these results, we can suggest that dyslexic children are able to use visual and somatosensory information to control their posture and use the same underlying neural control processes as non-dyslexic children. However, dyslexic children show poorer performance and more variability while relating visual and somatosensory information and motor action even during a task that does not require an active cognitive and motor involvement. Further, in sensory conflict conditions, dyslexic children showed less coherent and more variable body sway. These results suggest that dyslexic children have difficulties in multisensory integration because they may suffer from integrating sensory cues coming from multiple sources.
Learning mixtures of arbitrary gaussians

Mixtures of gaussian (or normal) distributions arise in a variety of application areas. Many techniques have been proposed for the task of finding the component gaussians given samples from the mixture, such as the EM algorithm, a local-search heuristic from Dempster, Laird and Rubin~(1977). However, such heuristics are known to require time exponential in the dimension (i.e., number of variables) in the worst case, even when the number of components is $2$. This paper presents the first algorithm that provably learns the component gaussians in time that is polynomial in the dimension. The gaussians may have arbitrary shape provided they satisfy a “nondegeneracy” condition, which requires their high-probability regions to be not “too close” together.
Neurobiological Findings in Youth with Borderline Personality Disorder

Abstract This review summarizes recent neurobiological research into youth with borderline personality disorder (BPD) to better delineate the biological factors involved in the development of this disorder. Psychobiological studies when BPD first becomes manifest are of particular interest, because there are fewer confounding factors (e.g., duration of illness, drug abuse, medication, other therapeutic interventions) at this time. This article focuses on recent findings in the field of neuroimaging, neuropsychology, neuroendocrinology, genetics, and pain perception, and it aims to integrate these findings in a developmental psychopathology model of BPD. In studies of clinical samples of adults with BPD, structural imaging studies revealed abnormalities predominantly in the frontolimbic areas. Disturbances in emotional information processing—particularly involving negative stimuli—may mediate affective dysregulation as a core feature of BPD. Genetic studies could reveal that the stability of BPD traits in youth is largely influenced by a combination of genetic and non-shared environmental factors. Hyporesponsiveness to a laboratory stressor indicates an enduring alteration of the hypothalamic–pituitary–adrenal axis. Findings of a higher pain threshold indicate that pain processing is already disturbed during the early stages of BPD, which could contribute to the initiation or maintenance of self-injurious behavior. All biological factors, together with environmental risk factors, may contribute to the core symptoms of BPD: severe emotional and behavioral dysregulation. Further research should investigate the development of BPD in youth by using longitudinal designs to determine whether the neurobiological factors are a cause, an effect, or an epiphenomenon of BPD.
Directional histogram model for three-dimensional shape similarity

In this paper, we propose a novel shape representation we call directional histogram model (DHM). It captures the shape variation of an object and is invariant to scaling and rigid transforms. The DHM is computed by first extracting a directional distribution of thickness histogram signatures, which are translation invariant. We show how the extraction of the thickness histogram distribution can be accelerated using conventional graphics hardware. Orientation invariance is achieved by computing the spherical harmonic transform of this distribution. Extensive experiments show that the DHM is capable of high discrimination power and is robust to noise.
Genital Herpes: Review of the Epidemic and Potential Use of Type-Specific Serology

SUMMARY Prevention of genital herpes simplex virus (HSV) infections is desirable from both a public health standpoint and the patient’s perspective. A key factor in the spread of genital herpes infections is the high proportion of undiagnosed infections. Persons with subclinical or unrecognized infections are best diagnosed by accurate, type-specific antibody tests. Unfortunately, these tests are only now becoming widely available. The use of current, conventional (non-type-specific) serologic tests for diagnosis of herpes infections has resulted in confusion and misdiagnosis of patients. This review provides recent information on the epidemiology of genital herpes infections, describes the importance of subclinical herpes infection and shedding, summarizes the status of HSV type-specific serologic assays being developed, and provides indications for using such assays.
Excitation function of the quasifree contribution in the 2H(7Li, alpha alpha )n reaction at E0=28-48 MeV.

The $^{2}\mathrm{H}$${(}^{7}$Li, \ensuremath{\alpha}\ensuremath{\alpha})n reaction was studied in a kinematically complete experiment at energies between 28 and 48 MeV. Coincidence spectra show the contribution from the quasifree p${+}^{7}$Li\ensuremath{\rightarrow}\ensuremath{\alpha}+\ensuremath{\alpha} reaction. The excitation function of the quasifree reaction cross section at small neutron momenta was extracted and compared with the behavior of the free reaction cross section.
Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1

Combinational drug therapy is one of the most promising strategies in modern anticancer research. Traditional Chinese medicine (TCM) formulas represent a wealth of complex combinations proven successful over centuries of clinical application. One such formula used to treat a variety of diseases, including cancer, contains two herbs, whose main active components are Halofuginone (HF) and Artemisinin (ATS). Here we studied the anticancer synergism of HF and ATS in various cancer cell lines and in a xenograft nude mice model. We found that the HF-ATS combination arrested more cells at the G1/G0 phase than either one alone, with the concomitant increased levels of CDK2 inhibitors, p21Cip1 and p27Kip1. By knocking down p21Cip1 and p27Kip1 separately or simultaneously in HCT116 cells and MCF-7 cells, we found that p21Cip1 was required for HF induced G1/G0 arrest, whereas p21Cip1 and p27Kip1 were both required for ATS or HF-ATS combination-mediated cell cycle arrest. Moreover, HF-ATS combination synergistically inhibited tumor growth in xenograft nude mice, and this was associated with the increased levels of p21Cip1 and p27Kip1. Collectively, these data indicate that the upregulation of p21Cip1 and p27Kip1 contributes to the synergistic anticancer effect of the HF-ATS combination.
Computability of finite-time reachable sets for hybrid systems

In this paper we consider the computability of the evolution of hybrid systems, or equivalently, the computability of finite-time reachable sets. We use the framework of type-two computability theory and computable analysis, which gives a theory of computation for points, sets and maps by Turing machines, and is related to computable approximation. We show that, under suitable hypotheses, the system evolution may be lower or upper semicomputable, but cannot be both in the presence of grazing contact with the guard sets.
Cu HyBrID laser kinetics: optimization of HBr partial pressure and buffer-gas flow rate

A detailed investigation into the dependence of the densities of the principal plasma species in the laser discharge on the buffer-gas operating parameters is reported. Simple expressions for the densities of the Cu, Br, and H species are derived by considering their major mechanisms for production and loss. These predict that the atomic Cu and Br densities are proportional to the HBr mass flow rate, whereas the density of H species (i.e., H and H/sub 2/) is proportional to the added HBr partial pressure. The theory agrees well with "Hook" method measurements of Cu density in a 25-mm bore diameter device; the Cu density increases approximately in proportion to the HBr mass flow rate, whereas it depends only weakly on the HBr partial pressure. Measurements of the fraction of Cu atoms excited by the discharge pulse, the rate of regrowth of the ground-state Cu density during the inter-pulse period, and the pre-pulse plasma impedance, are also explained in accordance with the theory. The results show that the plasma conditions for maximum laser output, which are remarkably similar to those of other "halogen enhanced" Cu lasers, can be achieved more directly by adjusting the overall buffer flow rate with the partial pressure of the added HBr fixed at 1-2 mbar. The theory is also useful for predicting optimum buffer-gas conditions for a wide range of Cu HyBrID laser dimensions and operating conditions.
Coalitional Games for Distributed Collaborative Spectrum Sensing in Cognitive Radio Networks

Collaborative spectrum sensing among secondary users (SUs) in cognitive networks is shown to yield a significant performance improvement. However, there exists an inherent trade off between the gains in terms of probability of detection of the primary user (PU) and the costs in terms of false alarm probability. In this paper, we study the impact of this trade off on the topology and the dynamics of a network of SUs seeking to reduce the interference on the PU through collaborative sensing. Moreover, while existing literature mainly focused on centralized solutions for collaborative sensing, we propose distributed collaboration strategies through game theory. We model the problem as a non-transferable coalitional game, and propose a distributed algorithm for coalition formation through simple merge and split rules. Through the proposed algorithm, SUs can autonomously collaborate and self-organize into disjoint independent coalitions, while maximizing their detection probability taking into account the cooperation costs (in terms of false alarm). We study the stability of the resulting network structure, and show that a maximum number of SUs per formed coalition exists for the proposed utility model. Simulation results show that the proposed algorithm allows a reduction of up to 86.6% of the average missing probability per SU (probability of missing the detection of the PU) relative to the non-cooperative case, while maintaining a certain false alarm level. In addition, through simulations, we compare the performance of the proposed distributed solution with respect to an optimal centralized solution that minimizes the average missing probability per SU. Finally, the results also show how the proposed algorithm autonomously adapts the network topology to environmental changes such as mobility.
Chat Detection in an Intelligent Assistant: Combining Task-oriented and Non-task-oriented Spoken Dialogue Systems

Recently emerged intelligent assistants on smartphones and home electronics (e.g., Siri and Alexa) can be seen as novel hybrids of domain-specific task-oriented spoken dialogue systems and open-domain non-task-oriented ones. To realize such hybrid dialogue systems, this paper investigates determining whether or not a user is going to have a chat with the system. To address the lack of benchmark datasets for this task, we construct a new dataset consisting of 15,160 utterances collected from the real log data of a commercial intelligent assistant (and will release the dataset to facilitate future research activity). In addition, we investigate using tweets and Web search queries for handling open-domain user utterances, which characterize the task of chat detection. Experimental experiments demonstrated that, while simple supervised methods are effective, the use of the tweets and search queries further improves the F_1-score from 86.21 to 87.53.
Monitoring the Production of Polymer Nanocomposites by Melt Compounding with On-line Rheometry

Abstract Polymer nanocomposites are often prepared by melt compounding due to the suitability of the latter to industrial scale production. Even though monitoring the production process for quality control and/or optimization purposes is generally done off-line, the possibility of using on-line oscillatory rheometry has many inherent advantages. This work illustrates the use of a prototype rheometer to monitor the production of polymer nanocomposites by making measurements at specific locations along the extruder axis. The device is presented and its operation is explained. Examples of its use to characterize polypropylene and polyamide matrix nanocomposites with organoclays and carbon nanotubes are discussed, thus demonstrating the usefulness of the device.
Tolerability of Saxagliptin in Patients with Inadequately Controlled Type 2 Diabetes: Results from 6 Phase III Studies

BACKGROUND: Oral antihyperglycemic drugs used to treat type 2 diabetes mellitus (T2DM) vary in safety and tolerability. Treatment-related hypoglycemia and weight gain can exacerbate underlying disease. OBJECTIVES: To evaluate the tolerability of saxagliptin using data from phase III clinical trials. METHODS: Six 24-week randomized studies in 4,214 patients with T2DM were assessed. Saxagliptin 2.5 mg or 5 mg was compared with placebo in 2 trials of monotherapy in treatment-naïve patients and in 3 trials of add-on therapy to metformin, glyburide, or a thiazolidinedione; initial combination therapy with saxagliptin 5 mg plus metformin was compared with metformin monotherapy in treatment-naïve patients. Data from the monotherapy and add-on studies were pooled; data from the initial combination study were analyzed separately. No statistical analyses of between-group comparisons across studies were conducted for these safety analyses because of multiplicity of end points and relative lack of statistical power and because small differences not reaching statistical significance have the potential to be clinically relevant. RESULTS: In the pooled analysis, incidence rates for adverse events (AEs) with saxagliptin 2.5 mg, 5 mg, and placebo were 72.0% (635/882), 72.2% (637/882), and 70.6% (564/799), respectively; rates for serious AEs (SAEs) were 3.5% (31/882), 3.4% (30/882), and 3.4% (27/799); rates of discontinuation due to AEs were 2.2% (19/882), 3.3% (29/882), and 1.8% (14/799). AEs reported in ≥ 2% of patients receiving saxagliptin and occurring ≥ 1% more frequently with saxagliptin than with placebo were sinusitis, gastroenteritis, abdominal pain, and vomiting. In the initial combination study, AE incidence rates with saxagliptin 5 mg plus metformin and metformin monotherapy were 55.3% (177/320) and 58.5% (192/328), respectively; incidence rates for SAEs were 2.5% (8/320) and 2.4% (8/328); and rates of discontinuation due to AEs were 2.5% (8/320) and 3.4% (11/328). CONCLUSIONS: Saxagliptin 2.5 mg or 5 mg was generally well tolerated as monotherapy, add-on combination therapy with other oral antihyperglycemic drugs, and initial combination with metformin.
Angiotensin II Activates Collagen I Gene Through a Mechanism Involving the MAP/ER Kinase Pathway

Vascular remodeling and rearrangement of the extracellular matrix formation are among the major adaptive mechanisms to chronic increase in blood pressure. In previous studies we have found that angiotensin II (Ang II) participates in the hypertension-associated aortic and renal vascular fibrosis by stimulating collagen type I formation. The purpose of the present study was to gain insight into the molecular events that lead from the Ang II receptor to collagen I gene activation. To this end, we used a novel strain of transgenic mice harboring the luciferase gene under the control of the collagen I-&agr;2 chain promoter [procol&agr;2(I)]. Ang II produced an early (1 hour) 2- to 3-fold stimulation of procol&agr;2(I) activity in freshly isolated aortas and renal cortical slices (P <0.01) followed by similar increase in procol&agr;2(I) mRNA aortic levels. This effect of Ang II was inhibited by AT1-receptor antagonism (candesartan) and blockade of the MAPK/ERK cascade (PD98059); in contrast, inhibition of the P38 kinase pathway (SB202190) and blockade of the release of the transcription factor NF&kgr;B (PDTC) did not have any effect in the Ang II–induced activation of the collagen I gene. In addition, Ang II induced a rapid (5 minutes) increase of the MAPK/ERK activity that was accompanied by increased expression (3-fold) of the c-fos proto-oncogene. This increase of c-fos mRNA expression was blocked by PD98059; in addition, curcumin, a blocker of the transcriptional factor AP-1, canceled the effect of Ang II on the collagen I gene. Decorin, a scavenger of the active form of transforming growth factor-&bgr; (TGF-&bgr;), canceled the Ang II effect on collagen I gene, whereas inhibition of the MAPK/ERK pathway had no effect on the TGF-&bgr;–induced activation of procol&agr;2(I). These data indicate that the cellular events after AT1 receptor stimulation and leading to activation of collagen I gene expression require activation of both the MAPK/ERK and TGF-&bgr; signaling pathways.