Miracle-dz/UniFAR-FTUs huggingface dataset:
Organizational/occupational commitment and organizational/occupational turnover intentions: A happy marriage?

Purpose – The purpose of this paper is to draw meaningful relationship between two foci of commitment (i.e. affective organizational and affective occupational) and two types of turnover intentions (i.e. organizational and occupational turnover intention). Design/methodology/approach – Using random sampling approach, the authors collected data from both academic and support staff of a Dutch university. An online questionnaire was developed and sent through electronic mail to 752 of the total employees. A total of 153 employees responded; yielding approximately 21 percent response rate. Findings – The results revealed that affective organizational commitment and affective occupational commitment were positively related to each other. Affective organizational commitment was negatively related to organizational turnover intention and this relationship was buffered by affective occupational commitment. Affective occupational commitment was negatively related both to occupational and organizational turnover in.
Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors

Purpose: PARP is essential for recognition and repair of DNA damage. In preclinical models, PARP inhibitors modulate topoisomerase I inhibitor–mediated DNA damage. This phase I study determined the MTD, dose-limiting toxicities (DLT), pharmacokinetics (PK), and pharmacodynamics (PD) of veliparib, an orally bioavailable PARP1/2 inhibitor, in combination with irinotecan. Experimental Design: Patients with advanced solid tumors were treated with 100 mg/m2 irinotecan on days 1 and 8 of a 21-day cycle. Twice-daily oral dosing of veliparib (10–50 mg) occurred on days 3 to 14 (cycle 1) and days −1 to 14 (subsequent cycles) followed by a 6-day rest. PK studies were conducted with both agents alone and in combination. Paired tumor biopsies were obtained after irinotecan alone and veliparib/irinotecan to evaluate PARP1/2 inhibition and explore DNA damage signals (nuclear γ-H2AX and pNBS1). Results: Thirty-five patients were treated. DLTs included fatigue, diarrhea, febrile neutropenia, and neutropenia. The MTD was 100 mg/m2 irinotecan (days 1 and 8) combined with veliparib 40 mg twice daily (days −1–14) on a 21-day cycle. Of 31 response-evaluable patients, there were six (19%) partial responses. Veliparib exhibited linear PK, and there were no apparent PK interactions between veliparib and irinotecan. At all dose levels, veliparib reduced tumor poly(ADP-ribose) (PAR) content in the presence of irinotecan. Several samples showed increases in γ-H2AX and pNBS1 after veliparib/irinotecan compared with irinotecan alone. Conclusions: Veliparib can be safely combined with irinotecan at doses that inhibit PARP catalytic activity. Preliminary antitumor activity justifies further evaluation of the combination. Clin Cancer Res; 22(13); 3227–37. ©2016 AACR.
Characterisation of a mouse model of chronic cerebral hypoperfusion and its application to investigating the impact of hypoperfusion on the development of Alzheimer’s disease

s Coltman R, Spain A, Tsenkina Y, Smith J, Fowler JH, Ihara M, Kalaria RN, Daumas S, Kelly P, Deary IJ, Wood E, McCulloch J, Horsburg h K. (2009). Chronic cerebral hypoperfusion causes myelin damage and is associate d with a selective impairment in working memory. International Conference on Alzheimer’s Disease. Vienna, Austria, July Coltman, R. , Kalaria, R. , Ihara, M. , Deary, I.J., McCulloch, J., Fowler, J., Horsburgh, K. (2009) Varying severities of chronic hypoperfusion on the development of Alzheimer’s disease pathology Research into Ageing Grantholders' Conference . Birmingham, UK, September Coltman, R. , Spain, A. , Fowler, J., Ihara, M. , Kala ria, R. , Daumas, S. , Wood, E. , Kelly, P., Deary, I. J., McCulloch, J., Horsburgh, K. (2008). White matter integrity is compromised in response to chronic cerebral hypoper fusion and may impact on cognition in ageing. Research into Ageing Grantholders' Conference . Birmingham, UK, September Horsburgh, K. , Bastin, M. E. , Jansen, M. A. , Merrif ield, G. D. , Coltman, R. B. , Spain, A. , Tsenkina, Y. , Scullion, G. , Scott, F. , M arshall, I. , Wardlaw, J., Wood, E. , Deary, I. J., McCulloch, J., Holland, P. R. (2010). In vivo evaluation of diffusion tensor and magnetization transfer imaging in a mous e model of selective white matter pathology. Society for Neuroscience. San Diego, USA. November. Scullion, G. , Fowler, J. H. , Karali, K. , Coltman, R . , Green, G. , Smith, C. , Horsburgh, K. (2010). Increased accumulation of amyloid in whi te matter in Alzheimer’s disease brains and transgenic models. 13 International Conference on Alzheimer’s Disease and related diseases. Honolulu, USA, July. Scullion, G. , Coltman, R. , Fowler, J. H. , Horsburgh , K. (2010). The influence of chronic cerebral hypoperfusion on Alzheimer’s disea se-like pathology in 3xTg mice. 13 International Conference on Alzheimer’s Disease an d related diseases. Honolulu, USA, July.
The Ontogeny of Taste Perception and Preference Throughout Childhood

The study of the ontogeny of human taste perception has been the focus of scientific investigations for more than a century (as summarized in Table 36.1). From this knowledge base, we now know that humans are born with a well-developed peripheral taste system—a taste system that, by the last trimester of pregnancy, is capable of conveying information to the central nervous system. This information is made available to brain structures critical for organizing a variety of consummatory (e.g., intake) and reflex-like (e.g., facial expressions) behaviors; (see Ganchrow and Mennella, 2003, for an earlier review). Clearly, taste plays an important role in determining whether a foreign substance should be accepted or rejected, and informs the gastrointestinal system about the quality and quantity of the impending rush of nutrients (Egan and Margolskee, 2008; Sclafani, 2007). Although the taste system involves innate responses, these responses change and mature throughout childhood, as will be described in this chapter (e.g., Cowart, 1981; Mennella et al., 2010b; Stein et al., 1994). The sense of taste has taken on great interest in recent years because it is a major determinant of the food acceptance patterns of children (Birch 1998). Thus, our accumulating knowledge about taste plays an important role in understanding the basis for food choices in children. Although the modernization and industrialization of the food supply have produced many benefits, diets rich in sugars and salt and low in fruits and vegetables have become increasingly commonplace, thereby producing unanticipated consequences. For example, excessive intake
Genetic variability and phylogeny of the high‐risk HPV‐31, ‐33, ‐35, ‐52, and ‐58 in central Brazil

More than 100 HPV types have been described, 13 of which are classified as high‐risk due to their association with the development of cervical cancer. The intratype genomic diversity of HPV‐16 and ‐18 has been studied extensively, while little data have been generated for other less common high‐risk types. The present study explores the nucleotide variability and phylogeny of the high‐risk HPV‐31, ‐33, ‐35, ‐52, and ‐58, in samples from Central Brazil. For this purpose, the LCR and the E6 and L1 genes were sequenced. Several variants of these HPV types were detected, some of which have been detected in other parts of the world. Furthermore, new variants of all types examined were characterized in a total of 13 new variants. Based on the E6 and L1 sequences, variants were described comprising conservative and non‐conservative amino acid changes. For phylogenetic tree construction, samples characterized in this study were compared to others described and submitted to GenBank previously. The phylogenetic analysis of HPV‐31, ‐33, ‐35, and ‐58 isolates did not reveal ethnic or geographical clustering as observed previously for HPV‐16 and ‐18. HPV‐35 analysis showed a dichotomic branching characteristic of viral subtypes. Interestingly, four clusters relative to the analysis of HPV‐52 isolates were identified, two of which could be classified as Asian and European branches. The genomic characterization of HPV variants is crucial for understanding the intrinsic geographical relatedness and biological differences of these viruses and contributes further to studies on their infectivity and pathogenicity. J. Med. Virol. 81:685–692, 2009 © 2009 Wiley‐Liss, Inc.
A new direct torque control strategy for the minimization of common-mode emissions

This paper presents a new direct torque control (DTC) algorithm for induction machine drives capable of reducing the common-mode conducted emissions of the drive. It is based on the application of only odd or only even voltage vectors in each sector in which the stator flux lies. In the work, after an overview of the generation of common-mode emissions of inverter fed drives and the most employed techniques for their minimization, a simplified equivalent circuit of the common-mode path has been identified to be used in numerical simulation on the basis of experimental measurements. Then, the new DTC technique has been described and applied to an induction machine drive, both in numerical simulation and experimentally on a suitably developed test setup. Finally, results are presented and compared to those obtained with the classic DTC technique. It has been shown that this methodology is able to reduce the common-mode voltage repetition rate, and therefore the resulting common-mode currents in comparison with the classic DTC in a frequency range of about tens of kilohertz. Finally the analysis of the impact of both control techniques in terms of the current absorbed by the grid has been performed.
Investigating the Relationship Between β‐Blocker and Antidepressant Use Through Linkage of the Administrative Databases of Saskatchewan Health

The main objectives of this research were to confirm previous reports of an increased risk of antidepressant use subsequent to propranolol therapy, and to determine whether this higher relative risk (RR) is indicative of depressive symptoms as a side‐effect of the drug's use. ‘New’ users of β‐blockers, other antihypertensives or diuretics in two separate years were identified from records of Saskatchewan Health. Incidence of concurrent antidepressants prescribing was determined in the year after initiating therapy with a cohort drug. Medical claims were examined to identify physician services and diagnoses associated with cohort drug and antidepressant prescriptions. Risk of concurrent antidepressant use in new propanolol users aged 20–39 years was approximately double that of new diuretic users [RR 2.2 (1.5–3.3) in 1984 and 2.0 (1.1–3.5) in 1990/91]. When cases with a diagnosis of migraine headache were excluded, the risk of concurrent propranolol/antidepressant use was age‐ and sex‐dependent, but not consistent for the two study years. It was concluded that although the risk of concurrent antidepressant use was greater in younger propranolol users, the risk cannot be solely attributed to depressive side‐effects of the drug. The purposes of this paper were to present the methods employed in linking the databases of Saskatchewan Health, describe the results of the analysis, and to highlight the methodologic problems that arose. © 1997 by John Wiley & Sons, Ltd.
Linking Work Design to Mass Customization: A Sociotechnical Systems Perspective

Mass customization has gained increasing importance in recent years due to its ability to provide customized products efficiently and effectively, and manufacturing companies are continuously searching for ways to develop their mass-customization ability. Despite extensive literature focusing on mass customization, few studies have systematically examined the impact of work-design practices on a company's mass-customization ability. Using the Sociotechnical Systems theory as a foundation, we link work-design practices with mass-customization ability, specifically identifying ten work-design practices and examining their impact on mass-customization ability using survey data and empirical research methods. The results support our hypothesized links and suggest that work-design practices that manage both the technical and the social dimensions for achieving organization success have significant impact on a company's ability to achieve mass customization.
In pursuit of the ideal masculine body : a phenomenological-hermeneutic approach

A phenomenological-hermeneutic approach was used to research men's experience with attempting to achieve an 'ideal' masculine body. The current North American 'ideal' male body, media and cultural influences, a continuum of exercise and dieting behaviors, steroid use, addictions, eating disorders, and personality traits associated with bodybuilders and individuals with eating disorders were presented as factors that may provide insight into this phenomenon. Eight male research participants were interviewed in regards to their experiences with attempting to achieve an 'ideal' masculine body. A dramaturgical life story approach to interviewing was used. A follow-up interview was conducted to allow each research participant to comment on the emerging themes shared by the researcher. The nine themes that emerged from the participants' stories are: (1) I am not good enough, (2) judging genetics, (3) spiraling into obsession, (4) extreme commitment, (5) join the club, (6) no one understands me, (7) control, (8) it's all an optical illusion, and (9) overcoming the obsession. The results of this thesis combined with the literature suggest the following three conclusions. First, men who attempt to achieve an ideal masculine body may be vulnerable to external messages about their bodies. Second, pre-existing personality traits and/or mental health issues may contribute to this vulnerability. Third, some men may attempt to deal with complex mental health issues by taking their 'frustrations' and 'aggression' out in the gym, rather than by seeking counselling. The implications for helping professionals are discussed. The limitations of this approach are acknowledged and directions for future research are suggested.
High SNR analysis of the MIMO interference channel

The rate region achievable by two transmitter-receiver pairs who wish to communicate over a Gaussian interference channel has been the subject of intense study over the last decades. Recently, the high SNR capacity region of this channel has been completely characterized in a work by Etkin, Tse and Wang (2007). In this paper, we study the effect of adding random fading into the picture, as well as multiple antennas at the transmitters and the receivers. Under the fast fading assumption, we recover a result of the same type as that obtained in the above mentioned paper. Under the slow fading assumption, we obtain an upper bound on the maximally achievable diversity order for a given target rate pair, which we conjecture to be tight.
Divergent selection maintains adaptive differentiation despite high gene flow between sympatric rainbow smelt ecotypes (Osmerus mordax Mitchill)

In this study, we investigate the relative role of historical factors and evolutionary forces in promoting population differentiation in a new case of sympatric dwarf and normal ecotypes of the rainbow smelt (Osmerus mordax Mitchill) in Lac Saint‐Jean (Québec, Canada). Our first objective was to test the hypothesis that the evolution of sympatric smelt ecotypes in Lac Saint‐Jean has been contingent upon the secondary contact between two evolutionary lineages in postglacial times. Secondly, the QST method was applied to test the null hypothesis that the extent of phenotypic differences relative to that of neutral marker variation would be similar in comparisons involving populations within and among ecotypes. Thirdly, we applied a quantitative‐genetic method as an exploratory assessment as to whether the amount of gene flow observed between populations could affect divergence in adaptive traits under specific conditions. This study revealed a unique situation of dwarf and normal smelt ecotypes that are, respectively, characterized by selmiparous and iteroparous life histories and the occurrence in each of two genetically distinct populations that synchronously use the same spawning habitat in two tributaries. Historical contingency has apparently played little role in the origin of these populations. In contrast, an important role of divergent natural selection in driving their phenotypic divergence was suggested. While divergent selection has apparently been strong enough to maintain phenotypic differentiation in the face of migration, this study suggests that gene flow has been sufficiently important to modulate the extent of adaptive differentiation being achieved between ecotypes, unless the extent of stabilizing selection acting on smelt ecotypes is much more pronounced than usually reported in natural populations.
Hypo- and Hyperglycemia Impair Endothelial Cell Actin Alignment and Nitric Oxide Synthase Activation in Response to Shear Stress

Uncontrolled blood glucose in people with diabetes correlates with endothelial cell dysfunction, which contributes to accelerated atherosclerosis and subsequent myocardial infarction, stroke, and peripheral vascular disease. In vitro, both low and high glucose induce endothelial cell dysfunction; however the effect of altered glucose on endothelial cell fluid flow response has not been studied. This is critical to understanding diabetic cardiovascular disease, since endothelial cell cytoskeletal alignment and nitric oxide release in response to shear stress from flowing blood are atheroprotective. In this study, porcine aortic endothelial cells were cultured in 1, 5.55, and 33 mM D-glucose medium (low, normal, and high glucose) and exposed to 20 dynes/cm2 shear stress for up to 24 hours in a parallel plate flow chamber. Actin alignment and endothelial nitric oxide synthase phosphorylation increased with shear stress for cells in normal glucose, but not cells in low and high glucose. Both low and high glucose elevated protein kinase C (PKC) levels; however PKC blockade only restored actin alignment in high glucose cells. Cells in low glucose instead released vascular endothelial growth factor (VEGF), which translocated β-catenin away from the cell membrane and disabled the mechanosensory complex. Blocking VEGF in low glucose restored cell actin alignment in response to shear stress. These data suggest that low and high glucose alter endothelial cell alignment and nitric oxide production in response to shear stress through different mechanisms.
Why is it difficult to search for two colors at once? How eye movements can reveal the nature of representations during multi-target visual search

representations of guns, knives and bombs. Further, the experiment encouraged color selectivity, but also contained a difficult shape manipulation. Thus, the reduction in selectivity may be a reflection of the objects containing features across two different dimensions, but it is difficult to disentangle the effects each dimension has on this reduction. The current study utilizes a similar paradigm but maintains tight control over the features and dimensions used. The purpose of the current investigation is to examine how multiple targets that vary across a single feature dimension are represented to guide
NEW ETHICAL CHALLENGES OF DISEASES IN THE GLOBALIZATION AGE

The appearance and worldwide circulation in the past few years of some new infectious (pathogenic) agents (such as coronaviruses, SARS) or other more virulent variants of already known viruses (influenza viruses H1N1 or H5N1, XDR tuberculosis) have raised concerns and determined a shift of attitude not only in the medical specialists but also at political level. The inefficiency or lack of some therapeutic or prophylactic methods with immediate application, the unpredictability that characterizes the spreading of these diseases, their severity (often unjustifiably exaggerated by the mass media) have nourished fears among the population, leading to the enforcement of quarantine measures to limit the disease, measures which have sometimes been less focused or not strong enough. In most cases, the idea of global security has prevailed over the right to free circulation, private ownership, or equal chances on the economic market. It is difficult to achieve a perfectly ethical division of resources allocated to fight infectious diseases in the current practice, but we must not overlook the fact that this has and will largely involve the socio-economically disadvantaged classes, while trying to limit the diseases strictly to a regional level only through administrative measures has proven, most often, to be a utopia. A stronger cooperation between healthcare specialists, on the one hand, and political factors and players in the pharmaceutical industry, on the other, may lead to a better management of these situations.
Analysis of the Core Genome and Pan-Genome of Autotrophic Acetogenic Bacteria

Acetogens are obligate anaerobic bacteria capable of reducing carbon dioxide (CO2) to multicarbon compounds coupled to the oxidation of inorganic substrates, such as hydrogen (H2) or carbon monoxide (CO), via the Wood-Ljungdahl pathway. Owing to the metabolic capability of CO2 fixation, much attention has been focused on understanding the unique pathways associated with acetogens, particularly their metabolic coupling of CO2 fixation to energy conservation. Most known acetogens are phylogenetically and metabolically diverse bacteria present in 23 different bacterial genera. With the increased volume of available genome information, acetogenic bacterial genomes can be analyzed by comparative genome analysis. Even with the genetic diversity that exists among acetogens, the Wood-Ljungdahl pathway, a central metabolic pathway, and cofactor biosynthetic pathways are highly conserved for autotrophic growth. Additionally, comparative genome analysis revealed that most genes in the acetogen-specific core genome were associated with the Wood-Ljungdahl pathway. The conserved enzymes and those predicted as missing can provide insight into biological differences between acetogens and allow for the discovery of promising candidates for industrial applications.
Critical Psychology: Contributions to an Historical Science of the Subject

Preface Acknowledgments Contributors 1. Critical psychology: an overview Charles W. Tolman 2. Critical psychology: historical background and task Wolfgang Maiers 3. Societal and individual life processes Klaus Holzkamp 4. Experience of self and scientific objectivity Klaus Holzkamp 5. Psychoanalysis and Marxist psychology Klaus Holzkamp 6. Emotion, cognition, and action potence Ute Holzkamp-Osterkamp 7. Action potence, education, and psychotherapy Ute Holzkamp-Osterkamp 8. Personality: self-actualization in social vacuums? Ute Holzkamp-Osterkamp 9. The concept of attitude Morus Markard 10. Client interests and possibilities in psychotherapy Ole Dreier 11. Play and Ontogenesis Karl-Heinz Brawn 12. Functions of the private sphere in social movements Frigga Haug Bibliography Index.