Miracle-dz/UniFAR-FTUs huggingface dataset:
Trends in Ectopic Pregnancy Mortality in the United States: 1980–2007

OBJECTIVE: To estimate trends in ectopic pregnancy mortality and examine characteristics of recently hospitalized women who died as a result of ectopic pregnancy in the United States. METHODS: We used 1980–2007 national birth and death certificate data to calculate ectopic pregnancy mortality ratios (deaths per 100,000 live births) overall and stratified by maternal age and race. We performed nonparametric tests for trend to assess changes in ectopic pregnancy mortality over time and calculated projected mortality ratios for 2013–2017. Ectopic pregnancy deaths among hospitalized women were identified from 1998–2007 Nationwide Inpatient Sample data. RESULTS: Between 1980 and 2007, 876 deaths were attributed to ectopic pregnancy. The ectopic pregnancy mortality ratio declined by 56.6%, from 1.15 to 0.50 deaths per 100,000 live births between 1980–1984 and 2003–2007; at the current average annual rate of decline, this ratio will further decrease by 28.5% to 0.36 ectopic pregnancy deaths per 100,000 live births by 2013–2017. The ectopic pregnancy mortality ratio was 6.8 times higher for African Americans than whites and 3.5 times higher for women older than 35 years than those younger than 25 years during 2003–2007. Of the 76 deaths among women hospitalized between 1998 and 2007, 70.5% were tubal pregnancies; salpingectomy was performed in 80.6% of cases. Excessive hemorrhage, shock, or renal failure accompanied 67.4% of ectopic pregnancy deaths among hospitalized women. CONCLUSION: Despite a significant decline in ectopic pregnancy mortality since the 1980s, age disparities, and especially racial disparities, persist. Strategies to ensure timely diagnosis and management of ectopic pregnancies can further reduce related mortality and age and race mortality gaps.
Novel role of sorting nexin 5 in renal D1 dopamine receptor trafficking and function: implications for hypertension

The D1 dopamine receptor (D1R) is widely expressed in the kidney and plays a crucial role in blood pressure regulation. Although much is known about D1R desensitization, especially through G‐protein‐coupled receptor kinase 4 (GRK4), comparatively little is known about other aspects of D1R trafficking and the proteins involved in the process. We now report the discovery of a dynamic interaction between sorting nexin 5 (SNX5), a component of the mammalian retromer, and D1R in human renal epithelial cells. We show that internalization of agonist‐activated D1R is regulated by both SNX5 and GRK4, and that SNX5 is critical to the recycling of the receptor to the plasma membrane. SNX5 depletion increases agonist‐activated D1R phosphorylation (>50% at basal condition), prevents D1R internalization and cAMP response, and delays receptor recycling compared to mock siRNA‐transfected controls. Moreover, renal restricted subcapsular infusion of Snx5‐specific siRNA (vs. mock siRNA) decreases sodium excretion (Δ= –0.2±0.005 mEq/mg creatinine) and further elevates the systolic blood pressure (Δ=48±5 mm Hg) in spontaneously hypertensive rats, indicating that SNX5 depletion impairs renal D1R function. These studies demonstrate an essential role for SNX5 in regulating D1R function, which may have important diagnostic, prognostic, and therapeutic implications in the management of essential hypertension. —Villar, V. A. M. , Armando, I. , Sanada, H. , Frazer, L. C. , Russo, C. M. , Notario, P. M. , Lee, H. , Comisky, L. , Russell, H. A. , Yang, Y. , Jurgens, J. A. , Jose, P. A. , Jones, J. E. Novel role of sorting nexin 5 in renal D1 dopamine receptor trafficking and function: implications for hypertension. FASEB J. 27, 1808–1819 (2013). www.fasebj. org
The role of microtubule-associated protein 1B in axonal growth and neuronal migration in the central nervous system

In this review, we discuss the role of microtubule-associated protein 1B (MAP1B) and its phosphorylation in axonal development and regeneration in the central nervous system. MAP1B exhibits similar functions during axonal development and regeneration. MAP1B and phosphorylated MAP1B in neurons and axons maintain a dynamic balance between cytoskeletal components, and regulate the stability and interaction of microtubules and actin to promote axonal growth, neural connectivity and regeneration in the central nervous system.
The Meaning Maintenance Model: On the Coherence of Social Motivations

The meaning maintenance model (MMM) proposes that people have a needfor meaning; that is, a need to perceive events through a prism of mental representations of expected relations that organizes their perceptions of the world. When people's sense of meaning is threatened, they reaffirm alternative representations as a way to regain meaning-a process termedfluid compensation. According to the model, people can reaffirm meaning in domains that are differentfrom the domain in which the threat occurred. Evidenceforfluid compensation can be observed following a variety of psychological threats, including most especially threats to the self, such as self-esteem threats, feelings of uncertainty, interpersonal rejection, and mortality salience. People respond to these diverse threats in highly similar ways, which suggests that a range of psychological motivations are expressions of a singular impulse to generate and maintain a sense of meaning.
A Metamodel Independent Approach to Difference Representation

It is of critical relevance that designers are able to comprehend the various kinds of design-level modifications that a system undergoes throughout its entire lifecycle. In this respect, an interesting and useful operation between subsequent system versions is the model difference calculation and representation. In this paper, a metamodel independent approach to the representation of model differences which is agnostic of the calculation method is presented. Given two models which conform to a metamodel, their difference is conforming to another metamodel derived from the former by an automated transformation. Difference models are first-class entities which induce transformations able to apply the modifications they specify. Finally, difference models can be composed sequentially and in parallel giving place to more complex modifications.
Frog skeletal muscle thick filaments are three-stranded

A procedure has been developed for isolating and negatively staining vertebrate skeletal muscle thick filaments that preserves the arrangement of the myosin crossbridges. Electron micrographs of these filaments showed a clear periodicity associated with crossbridges with an axial repeat of 42.9 nm. Optical diffraction patterns of these images showed clear layer lines and were qualitatively similar to published x-ray diffraction patterns, except that the 1/14.3-nm meridional reflection was somewhat weaker. Computer image analysis of negatively stained images of these filaments has enabled the number of strands to be established unequivocally. Both reconstructed images from layer line data and analysis of the phases of the inner maxima of the first layer line are consistent only with a three-stranded structure and cannot be reconciled with either two- or four-stranded models.
Root biomass, turnover and net primary productivity of a coffee agroforestry system in Costa Rica: effects of soil depth, shade trees, distance to row and coffee age.

BACKGROUND AND AIMS In Costa Rica, coffee (Coffea arabica) plants are often grown in agroforests. However, it is not known if shade-inducing trees reduce coffee plant biomass through root competition, and hence alter overall net primary productivity (NPP). We estimated biomass and NPP at the stand level, taking into account deep roots and the position of plants with regard to trees. METHODS Stem growth and root biomass, turnover and decomposition were measured in mixed coffee/tree (Erythrina poeppigiana) plantations. Growth ring width and number at the stem base were estimated along with stem basal area on a range of plant sizes. Root biomass and fine root density were measured in trenches to a depth of 4 m. To take into account the below-ground heterogeneity of the agroforestry system, fine root turnover was measured by sequential soil coring (to a depth of 30 cm) over 1 year and at different locations (in full sun or under trees and in rows/inter-rows). Allometric relationships were used to calculate NPP of perennial components, which was then scaled up to the stand level. KEY RESULTS Annual ring width at the stem base increased up to 2·5 mm yr-1 with plant age (over a 44-year period). Nearly all (92 %) coffee root biomass was located in the top 1·5 m, and only 8 % from 1·5 m to a depth of 4 m. Perennial woody root biomass was 16 t ha-1 and NPP of perennial roots was 1·3 t ha-1 yr-1 Fine root biomass (0-30 cm) was two-fold higher in the row compared with between rows. Fine root biomass was 2·29 t ha-1 (12 % of total root biomass) and NPP of fine roots was 2·96 t ha-1 yr-1 (69 % of total root NPP). Fine root turnover was 1·3 yr-1 and lifespan was 0·8 years. CONCLUSIONS Coffee root systems comprised 49 % of the total plant biomass; such a high ratio is possibly a consequence of shoot pruning. There was no significant effect of trees on coffee fine root biomass, suggesting that coffee root systems are very competitive in the topsoil.
Determination of Host Fish Suitability for Unio terminalis delicatus (Bivalvia:Unionidae) From Gölbaşı Lake in Turkey

Suitable host fishes were identified for Unio terminalis delicatus (Unionidae) from Golbasi lake. It was observed the glochidial infestation for the suitable host fishes in the laboratory conditional. In this study, five different fish specieses ( Anguilla anguilla, Clarius gariepinus, Barbus luteus, Orechromis niloticus, Cyprinus carpio ) were used as host fish in order to U. terminalis delicatus . It was placed in each aquarium eighteen fish and three mussels. Fishes, which are used as host were held in five aquariums of 140 liters capacity with no substrate. All the aquarium were sampled every other day for up to 45 days. The presence of glochidia in the gills and fins of the fish was studied in a stereomicroscope. The following stage, mussel-fish-host relationships were established. In the aquarium in which C. carpio was placed, the conglutinates were found to differ both in quantity and in structural form. Although the larvae of U. terminalis delicatus released successfully on three fishes species: B. luteus , C. carpio and O. niloticus , they weren't prefer to A. Anguilla and C . gariepinus as host fish. These observations show that of three prefable host, C. carpio is the best option to for host fish selectivity U. terminalis delicatus
Intracerebral functional connectivity-guided neurofeedback as a putative rehabilitative intervention for ameliorating auditory-related dysfunctions

Electroencephalography (EEG) constitutes one of the most eligible candidates for neurofeedback applications, principally due to its excellent temporal resolution best reflecting the natural dynamics of brain processes. In addition, EEG is easy to use and provides the opportunity for mobile applications. In the present opinion article, we pinpoint the advantages of using intracerebral functional connectivity (IFC) instead of quantitative scalp EEG for interventional applications. In fact, due to the convergence of multiple signals originating from different spatial locations and electrophysiological interactions, miscellaneous scalp signals are too unspecific for therapeutic neurofeedback applications. Otherwise, IFC opens novel perspectives for influencing brain activity in specific dysfunctional small- and large-scale neuronal networks with a reasonable spatial resolution. In the present article, we propose concrete interventional IFC applications that may be used to ameliorate auditory-related dysfunctions such as developmental dyslexia.
Analysis of physico-chemical and bacteriological quality of drinking water in Mafikeng, South Africa.

Mafikeng, the capital of the North West Province, receives water from two sources, namely the Molopo eye and the Modimola dam. Once treated, the potable water is mixed and supplied to the city via distribution systems. This study was designed to assess the quality of drinking water in Mafikeng and also to determine whether the water from the two sources has an impact on the mixed water quality. Physico-chemical parameters and bacteriological quality (faecal coliforms (FCs), total coliforms (TCs), heterotrophic bacteria and Peudomonas spp. ) was monitored at three drinking water sites weekly for 4 months. The results revealed that the physico-chemical quality of the water was generally acceptable. The pH ranged from 5.7 ± 0.18 to 8.6 ± 0.14, the temperature ranged from 18.3 ± 0.69 to 25.1 ± 0.69 °C and the total dissolved solids (TDS) ranged from 159.9 ± 22.44 to 364.4 ± 12.44 mg/l. These values are within the target water quality range for drinking water as prescribed by WHO, Department of Water Affairs and SANS 241. What is of concern was the microbial quality of the water. FCs, TCs, heterotrophic bacteria and Pseudomonas spp. were present in some of the treated water samples. The most significant finding of this study is that all drinking water samples were positive for Pseudomonas spp. (>100/100 ml).
Decisional Annotations

This chapter deals with an annotation-based decisional system. The decisional system we present is based on multidimensional databases, which are composed of facts and dimensions. The expertise of decision-makers is modelled, shared and stored through annotations. These annotations allow decision-makers to carry on active analysis and to collaborate with other decision-makers on a common analysis.
Principal determinants of species and functional diversity of carabid beetle assemblages during succession at post-industrial sites

Abstract Although ecological succession is one of the principal focuses of recent restoration ecology research, it is still unclear which factors drive this process and positively influence species richness and functional diversity. In this study we sought to elucidate how species traits and functional diversity change during forest succession, and to identify important factors that determine the species in the observed assemblages. We analyzed species richness and functional diversity of ground beetle assemblages in relation to succession on post-industrial localities after habitat deterioration caused by spoil deposition. We selected ground beetles as they are known to be sensitive to landscape changes (with a large range of responses), and their taxonomy and ecology are generally well-known. Ground beetles were sampled on the spoil heaps during the last 30 years when spontaneous succession occurred. To calculate functional diversity, we used traits related to habitat and trophic niche, i.e. food specialization, wing morphology, trophic level, and bio-indication value. Ground beetle species were found to be distributed non-randomly in the assemblages in the late phase of succession. Ordination analyses revealed that the ground beetle assemblage was significantly associated with the proportion of forested area. Environmental heterogeneity generated assemblages that contained over-dispersed species traits. Our findings indicated that environmental conditions at late successional stages supported less mobile carnivorous species. Overall, we conclude that the decline in species richness and functional diversity in the middle of the studied succession gradient indicated that the assemblages of open habitats had been replaced by species typical of forest ecosystems.
Sertindole in the treatment of psychosis in schizophrenia: efficacy and safety

Evidence from clinical trials supports the claim that sertindole is a potent antipsychotic drug at a dose of 12–24 mg/day. Its action against positive symptoms is as potent as that of the traditional antipsychotic haloperidol. Its action against negative; symptoms is significantly different from that of placebo and quantitatively larger than that of haloperidol. Its most distinctive characteristic is a reduction in motor side effects over a whole range of comparable drug and comparator doses. More work is needed to determine whether sertindole's actions against negative symptoms influence the primary or the secondary negative system, There are insufficient data at present to compare sertindole with the highly efficacious drug clozapine or the other new antipsychotic olanzapine.
Transformations in the water relations in the Wieczno Południowe lake catchment (Chełmno Lakeland, Poland)

Abstract The research involved a detailed analysis of transformations in water relations in the Wieczno Południowe (Wieczno South) lake drainage basin in central Poland, in the physical geographical region of the Chełmno Lakeland. Significant changes were identified in the water relations in the catchment, which were caused by a number of anthropogenic factors. The most significant factors include land development works, changes in land use (a decrease in wetland area in favour of arable land), and the extraction of water from Lake Wieczno South (for irrigation purposes) and the creation of a weir construction on its outflow. It has been shown that in recent years the drainage basin’s water resources have been affected by climate fluctuations manifested as an increase in sums of evaporation. As a result of the deterioration of water relations in the catchment, the hydrological type of some lakes (Płużnica, Wieczno North and Wieczno South) have changed, which unexpectedly resulted in an improvement of their water quality. Taking into account the forecasts for further climate change, this factor will probably have a decisive influence on the water relations of the studied area in the coming years.
The effect of intravenous thrombolytic therapy on left ventricular function: a report on tissue-type plasminogen activator and streptokinase from the Thrombolysis in Myocardial Infarction (TIMI Phase I) trial.

In Phase I of the NHLBI trial of Thrombolysis in Myocardial Infarction (TIMI), 290 patients admitted within 7 hr after onset of acute infarction were randomly assigned to intravenous treatment with either streptokinase (SK) or recombinant tissue-type plasminogen activator (rt-PA). Left ventricular function was measured from contrast ventriculograms in 145 patients with both pretreatment and predischarge studies analyzable. Regional wall motion in the infarct site was measured by the centerline method and expressed in units of standard deviations (SDs) from the mean motion in 52 normal subjects. Patients treated with rt-PA (n = 77) achieved a significantly higher reperfusion rate after 90 min of treatment. Perfusion of the infarct-related artery improved from visual grade 0 or 1 (total occlusion or penetration without perfusion) to grade 2 or 3 (partial or full reperfusion) in 62% receiving rt-PA vs 31% receiving SK (n = 68) (p less than .001). However, the ejection fraction did not change significantly from before treatment to before discharge in either treatment group (+0.7 +/- 6.7% vs +1.0 +/- 8.3%, respectively). A small but significant increase in regional wall motion was observed in each of the two groups (+0.4 +/- 0.8 vs +0.3 +/- 0.8 SD/chord, respectively; each p less than .001 compared with baseline). This was countered by declines in the hyperkinesis of the noninfarct region (-0.3 +/- 1.0 SD/chord [p = .01] compared with baseline and -0.2 +/- 1.0 SD/chord [p = .23], respectively). Analysis of the combined groups revealed that the ejection fraction increased only in patients who achieved reperfusion by 90 min after onset of therapy or who had subtotal occlusions initially. There was greater recovery of left ventricular function in patients who achieved reperfusion earlier vs later than 4 hr after symptom onset and in patients with vs without some collateral circulation to the infarct-related artery.
Schatten-$p$ Quasi-Norm Regularized Matrix Optimization via Iterative Reweighted Singular Value Minimization

In this paper we study general Schatten-$p$ quasi-norm (SPQN) regularized matrix minimization problems. In particular, we first introduce a class of first-order stationary points for them, and show that the first-order stationary points introduced in [11] for an SPQN regularized $vector$ minimization problem are equivalent to those of an SPQN regularized $matrix$ minimization reformulation. We also show that any local minimizer of the SPQN regularized matrix minimization problems must be a first-order stationary point. Moreover, we derive lower bounds for nonzero singular values of the first-order stationary points and hence also of the local minimizers of the SPQN regularized matrix minimization problems. The iterative reweighted singular value minimization (IRSVM) methods are then proposed to solve these problems, whose subproblems are shown to have a closed-form solution. In contrast to the analogous methods for the SPQN regularized $vector$ minimization problems, the convergence analysis of these methods is significantly more challenging. We develop a novel approach to establishing the convergence of these methods, which makes use of the expression of a specific solution of their subproblems and avoids the intricate issue of finding the explicit expression for the Clarke subdifferential of the objective of their subproblems. In particular, we show that any accumulation point of the sequence generated by the IRSVM methods is a first-order stationary point of the problems. Our computational results demonstrate that the IRSVM methods generally outperform some recently developed state-of-the-art methods in terms of solution quality and/or speed.
Prevalence and Risk Factors of Acute Lower Gastrointestinal Bleeding in Crohn Disease

AbstractAcute lower gastrointestinal bleeding (ALGIB) is a rare but potentially life-threatening complication of Crohn disease (CD). Thus far, few studies of ALGIB in the context of CD have been published, most of which were case reports with limited value. We aimed to explore the prevalence of ALGIB in CD patients, evaluate risk factors for hemorrhagic CD and its recurrence, and analyze clinical data of the death cases.A total of 1374 CD patients registered from January 2007 to June 2013 were examined. Medical records of 73 patients with ALGIB and 146 matched as controls were reviewed and analyzed retrospectively. Logistic regression and Cox proportional hazards analyses were performed to identify risk factors for ALGIB and the cumulative probability of rebleeding. Kaplan–Meier curves with log-rank tests were used to demonstrate the cumulative survival rates of rebleeding.The prevalence of ALGIB was 5.31% (73/1374) in this study. In the univariate analysis, possible risk factors for ALGIB were duration of CD (odds ratio [OR] 0.60, 95% confidence interval [CI] 0.33–1.09, P = 0.095), perianal disease (OR 1.96, 95% CI 0.92–4.20, P = 0.082), left colon involvement (OR 2.16, 95% CI 1.10–4.24, P = 0.025), azathioprine use ≥1 year (OR 0.46, 95% CI 0.23–0.90, P = 0.023), and previous hemorrhage history (OR 11.86, 95% CI 5.38–26.12, P < 0.0001). In the multivariate analysis, left colon involvement (OR 2.26, 95% CI 1.04–4.91, P = 0.039), azathioprine use ≥1 year (OR 0.44, 95% CI 0.20–0.99, P = 0.044), and previous hemorrhage history (OR 13.04, 95% CI 5.66–30.04, P < 0.0001) remained independent influencing factors. Older age (HR 0.23, 95% CI 0.07–0.77, P = 0.018), surgical treatment (HR 0.17, 95% CI 0.06–0.50, P < 0.001), and having bleeding episodes >3 months ago (HR 0.24, 95% CI 0.07–0.82, P = 0.022) resulted to be predictors associated with rebleeding after discharge. Patients who died often suffered severe concomitant diseases, and the overall mortality rate was 8.22% (6/73). We speculated that a special hemorrhagic phenotype of CD that was predisposed to rebleeding may exist. Further studies are warranted to investigate the pathogenesis and discover the optimum treatments of choice.