Miracle-dz/UniFAR-FTUs huggingface dataset:
Report on Guantanamo Detainees: A Profile of 517 Detainees through Analysis of Department of Defense Data

The media and public fascination with who is detained at Guantanamo and why has been fueled in large measure by the refusal of the Government, on the grounds of national security, to provide much information about the individuals and the charges against them. The information available to date has been anecdotal and erratic, drawn largely from interviews with the few detainees who have been released or from statements or court filings by their attorneys in the pending habeas corpus proceedings that the Government has not declared "classified. " This Report is the first effort to provide a more detailed picture of who the Guantanamo detainees are, how they ended up there, and the purported bases for their enemy combatant designation. The data in this Report is based almost entirely upon the United States Government's own documents. This Report provides a window into the Government's success detaining only those that the President has called "the worst of the worst. " Among the findings of the Report: 1. Fifty-five percent (55%) of the detainees are not determined to have committed any hostile acts against the United States or its coalition allies. 2. Only 8% of the detainees were characterized as al Qaeda fighters. Of the remaining detainees, 40% have no definitive connection with al Qaeda at all and 18% are have no definitive affiliation with either al Qaeda or the Taliban. 3. The Government has detained numerous persons based on mere affiliations with a large number of groups that, in fact, are not on the Department of Homeland Security terrorist watchlist. Moreover, the nexus between such a detainee and such organizations varies considerably. Eight percent are detained because they are deemed "fighters for;" 30% considered "members of;" a large majority - 60% - are detained merely because they are "associated with" a group or groups the Government asserts are terrorist organizations. For 2% of the prisoners, a nexus to any terrorist group is not identified by the Government. 4. Only 5% of the detainees were captured by United States forces. 86% of the detainees were arrested by either Pakistan or the Northern Alliance and turned over to United States custody. This 86% of the detainees captured by Pakistan or the Northern Alliance were handed over to the United States at a time in which the United States offered large bounties for capture of suspected enemies. 5. Finally, the population of persons deemed not to be enemy combatants - mostly Uighers - are in fact accused of more serious allegations than a great many persons still deemed to be enemy combatants.
TOPOLOGICAL CLASSIFICATION OF BLACK HOLES: GENERIC MAXWELL SET AND CREASE SET OF A HORIZON

The crease set of an event horizon or a Cauchy horizon is an important object which determines the qualitative properties of the horizon. In particular, it determines the possible topologies of the spatial sections of the horizon. By Fermat's principle in geometric optics, we relate the crease set and the Maxwell set of a smooth function in the context of singularity theory. We thereby give a classification of generic topological structures of the Maxwell sets and the generic topologies of the spatial section of the horizon.
Finance Applications of Game Theory

Traditional finance theory based on the assumptions of symmetric information and perfect and competitive markets has provided many important insights. These include the Modigliani and Miller Theorems, the CAPM, the Efficient Markets Hypothesis and continuous time finance. However, many empirical phenomena are difficult to reconcile with this traditional framework. Game theoretic techniques have allowed insights into a number of these. Many puzzles remain. This paper argues that recent advances in game theory concerned with higher order beliefs, informational cascades and heterogeneous prior beliefs have the potential to provide insights into some of these remaining puzzles.
Activation of Broca's area by syntactic processing under conditions of concurrent articulation

Regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) when 11 subjects made plausibility judgments about written sentences that varied in their syntactic complexity. While making their judgments, subjects uttered the word “double” aloud at a rate of one utterance per second to inhibit their ability to rehearse the sentences. Blood flow increased in Broca's area when subjects made judgments about the more complex sentences. This result replicates and extends previous findings that blood flow increases in this region when subjects process complex syntax under no interference conditions. The results of this experiment provide strong evidence that the increase in blood flow seen in Broca's area in association with processing syntactically complex structures is not due to subvocal rehearsal of those structures, but rather results from processing syntactic forms themselves. Hum. Brain Mapping 9:65–71, 2000. © 2000 Wiley‐Liss, Inc.
Greed as a Source of Polarization

Political contributions appear to be subject to an obvious public goods problem. Free riding might be expected to lead to polarization of contributions. We show that it is not true in general. In fact, in the most obvious model, with arbitrary number of candidates, we get a median contributor theorem. We then show how some polarization can be revived by adding some spending from campaign contributions on private consumption by the agent. We then use the model to analyze effects of campaign finance reforms including crackdowns on spending not directly on advertising.
Organizational Motivation and Interorganizational Systems Adoption Process: Empirical Evaluation in the Australian Automotive Industry

Interorganizational systems (IOS) play a critical role in todayâ€™s e-commerce environment. These systems are introduced by different organizations following different adoption processes. Existing literature on IOS adoption, however, does not explain the variations in the IOS adoption processes initiated by different organizations. A theory of IOS adoption known as IOS Motivation Model (IMM) has recently been developed by the authors that explains the differences in IOS adoption processes in terms of differences in organizationsâ€™ adoption motivations for any given IOS project. This paper reports an application of the model in the Australian automotive industry. The findings provide support for the model and are useful for IT managers.
THE RETENTION OF S35-LABELLED BOVINE SERUM ALBUMIN IN NORMAL AND IMMUNIZED RABBIT LIVER TISSUE

The S35-label of S35-BSA was detected in the liver tissue of rabbits to the extent of 0.02 per cent (10 µg or ≃ 1014 molecules) of the injected material at 140 days after injection. The rate of loss of antigen at the termination of the experiment was of such an order that significant amounts would be expected to persist for at least several years. Data are reported which extend the retention data previously reported on S35-labelled hemocyanin. They indicate that amounts of the order of 0.05 per cent (25 µg.) of antigen material persist at 330 days after injection. All of the radioactivity of material retained in the liver tissue 6 weeks after injection was immunologically related to the original S35-BSA antigen. Preliminary studies are reported which indicate that the retained antigen is bound to ribonucleic acid. A new method is described for the isolation of p-azophenylsulfonate bovine serum albumin from tissue extracts by means of a Dowex 2 adsorbent.
Local ensemble Kalman filtering in the presence of model bias

We modify the local ensemble Kalman filter (LEKF) to incorporate the effect of forecast model bias. The method is based on augmentation of the atmospheric state by estimates of the model bias, and we consider different ways of modeling (i.e. parameterizing) the model bias.We evaluate the effectiveness of the proposed augmented state ensemble Kalman filter through numerical experiments incorporating various model biases into the model of Lorenz and Emanuel. Our results highlight the critical role played by the selection of a good parameterization model for representing the form of the possible bias in the forecast model. In particular, we find that forecasts can be greatly improved provided that a good model parameterizing the model bias is used to augment the state in the Kalman filter.
B/RG/AN8285/APN19307: "Computational Intelligence, Creativity, and Cognition: A

AESTHETICS AND INTERACTIVE ART Many, perhaps most, questions about the aesthetics of interactive art are still open. For instance, a number of artists have said that the properties of the visual or musical product, or art object, are irrelevant. What matters is the nature of the interaction itself. But is that a reasonable position? If so, just what sort of interaction is to be valued here? A number of different criteria have been suggested, some of which are opposites. Does interactive art raise any questions about the identity of the "artist" which aren’t raised by other (non-interactive) examples of computer art? Perhaps the fundamentally new technologies involved demand a radically new aesthetic? If so, to what extent should that reflect specific properties of the technology as such? Or perhaps we can/should rely, to some extent at least, on familiar principles of aesthetics to evaluate interactive art?
Investigating time-efficiency of forward masking paradigms for estimating basilar membrane input-output characteristics

It is well known that pure-tone audiometry does not sufficiently describe individual hearing loss (HL) and that additional measures beyond pure-tone sensitivity might improve the diagnostics of hearing deficits. Specifically, forward masking experiments to estimate basilar-membrane (BM) input-output (I/O) function have been proposed. However, such measures are very time consuming. The present study investigated possible modifications of the temporal masking curve (TMC) paradigm to improve time and measurement efficiency. In experiment 1, estimates of knee point (KP) and compression ratio (CR) of individual BM I/Os were derived without considering the corresponding individual “off-frequency” TMC. While accurate estimation of KPs was possible, it is difficult to ensure that the tested dynamic range is sufficient. Therefore, in experiment 2, a TMC-based paradigm, referred to as the “gap method”, was tested. In contrast to the standard TMC paradigm, the maker level was kept fixed and the “gap threshold” was obtained, such that the masker just masks a low-level (12 dB sensation level) signal. It is argued that this modification allows for better control of the tested stimulus level range, which appears to be the main drawback of the conventional TMC method. The results from the present study were consistent with the literature when estimating KP levels, but showed some limitations regarding the estimation of the CR values. Perspectives and limitations of both approaches are discussed.
Evaluating LRRK2 Genetic Variants with Unclear Pathogenicity

Mutations in the leucine-rich repeat kinase 2 (LRRK2) have been known to be a major genetic component affecting Parkinson's disease (PD). However, the pathogenicity of many of the LRRK2 variants is unclear because they have been detected in single patients or also in patients and controls. Here, we selected 5 exonic variants (L1165P, T1410M, M1646T, L2063X, and Y2189C) from each of the protein domain of LRRK2 and analysed their possible association with pathogenicity using in vitro functional assays. Point mutations representing each of these variants were incorporated into the LRRK2 gene, and functional aspects such as the percentage of cell survival upon application of stress and kinase activity were measured. Our results showed that all 5 variants had a significantly negative effect on the survival of cells, in both presence and absence of stress, as compared to the wild-type. In addition, there was also a slight increase in kinase activity in most of the variants in comparison to the wild-type. A negative correlation between cell survival and kinase activity was observed. These data suggest that most of the variants despite being located in different domains of LRRK2 appear to exert a potential pathogenic effect possibly through an increased kinase activity, supporting a gain of function mechanism.
Efficient design of oversampled NPR GDFT filter banks

We present a flexible, efficient design technique for the prototype filter of an oversampled near perfect reconstruction (NPR) generalized discrete Fourier transform (GDFT) filter bank. Such filter banks have several desirable properties for subband processing systems that are sensitive to aliasing; e.g., subband adaptive filters. Our design criteria for the prototype filter are explicit bounds on the aliased components in the subbands, the aliased components in the output, and the distortion induced by the filter bank. It is shown that the design of an optimal prototype filter can be transformed into a convex optimization problem that can be efficiently solved. Our design technique provides an efficient and effective tool for exploring many of the inherent trade-offs in the design of the prototype filter, including the trade-off between aliasing in the subbands and the distortion induced by the filter bank. In our examples we calculate several of these trade-offs and demonstrate that our method can generate filters with significantly better performance than filters obtained using current design methods.
A mechanism for the juvenile-to-adult transition in fishes

The conventional view (Hoar, 1970; Liley, 1970; Harvey and Hoar, 1979) of the sequence of events which, in fish, leads to first gonadal maturation and subsequent spawning, starts with "environmental stimuli" which the brain and pineal gland process and pass on to the hypothalamus, which passes its information to the pituitary; gonadotropic hormones are then synthesized and released which leads to the maturation and release of gametes, given suitable environmental conditions (including a mate). Other more elaborate schemes allow for feedback loops (Kuo and Nash, 1975), but share with the linear sequence outlined above the feature that they invariably start with "environmental" or "external" stimuli. The conventional view of the link between growth and reproduction in fish is that of a "reproductive drain", i.e., the notion that fish, once they have reached sexual maturity, have a slower growth because the "energy" previously available for growth is, in mature fish, redirected toward the production of gonadal material (Jones, 1976; Lagler et ai., 1977). It is argued here that these conventional views can be replaced by a single hypothesis with the help of which a number of otherwise irreconcilable observations on the growth and reproduction of fish can be explained. b) a medium time scale (weeks to months) during which gonadal maturation takes place, as triggered by environmental stimuli; and c) a long time scale, in which the age and the size at which a fish becomes sexually mature for the first time are determined.
Estimating the General Equilibrium Benefits of Large Policy Changes: The Clean Air Act Revisited

This paper reports the first comprehensive approach for measuring the general equilibrium willingness to pay for large changes in air quality. It is based on a well defined locational equilibrium model. The approach allows estimation of households' indirect utility function and the underlying distribution of household types. With these estimates it is possible to compute a new locational equilibrium and the resulting housing prices in response to exogenous changes in air quality. This permits construction of welfare measures which properly take into consideration the adjustments of households in equilibrium to non-marginal changes in air quality. These types of measures are outside the scope of more traditional approaches. The empirical approach of this paper provides, for the first time, an internally consistent framework for estimation and applied general equilibrium welfare analysis. We compute the general equilibrium willingness to pay for the changes in air quality between 1990 and 1995. We implement our empirical framework using data from Southern California, an area which has experienced dramatic improvements in air quality during the past 20 years. Our findings are by and large supportive for our approach and suggest that accounting for general equilibrium effects in applied welfare can be especially important.
Survivin co-ordinates formation of follicular T-cells acting in synergy with Bcl-6

Follicular T helper (Tfh) cells are recognized by the expression of CXCR5 and the transcriptional regulator Bcl-6. Tfh cells control B cell maturation and antibody production, and if deregulated, may lead to autoimmunity. Here, we study the role of the proto-oncogene survivin in the formation of Tfh cells. We show that blood Tfh cells of patients with the autoimmune condition rheumatoid arthritis, have intracellular expression of survivin. Survivin was co-localized with Bcl-6 in the nuclei of CXCR5+CD4 lymphocytes and was immunoprecipitated with the Bcl-6 responsive element of the target genes. Inhibition of survivin in arthritic mice led to the reduction of CXCR5+ Tfh cells and to low production of autoantibodies. Exposure to survivin activated STAT3 and induced enrichment of PD-1+Bcl-6+ subset within Tfh cells. Collectively, our study demonstrates that survivin belongs to the Tfh cell phenotype and ensures their optimal function by regulating transcriptional activity of Bcl-6.
The relationship between blood lead levels and periodontal bone loss in the United States, 1988-1994.

An association between bone disease and bone lead has been reported. Studies have suggested that lead stored in bone may adversely affect bone mineral metabolism and blood lead (PbB) levels. However, the relationship between PbB levels and bone loss attributed to periodontal disease has never been reported. In this study we examined the relationship between clinical parameters that characterize bone loss due to periodontal disease and PbB levels in the U.S. population. We used data from the Third National Health and Nutritional Examination Survey (NHANES III), 1988-1994, for the analyses. A total of 10,033 participants 20-69 years of age who completed a periodontal examination and had whole blood tested for lead were examined. Four types of periodontal disease measures were used to indicate oral bone loss: periodontal pocket depth, attachment loss extent, attachment loss severity, and the presence of dental furcations. We found that dental furcations were the best periodontal bone loss indicator for PbB levels (p = 0.005) in a multivariate linear regression model adjusting for sex, age, race/ethnicity, educational attainment, poverty status, smoking, and age of home. Furthermore, after additional modeling, we found a smoking and dental furcation interaction (p = 0.034). Subsequent stratified analyses indicated that current and past smoking is an effect modifier for dental furcations on PbB levels. These findings indicate that increased PbB levels may be associated with advanced periodontal bone loss, particularly among people with a history of smoking.
Randomised controlled trial of mesalazine in IBS

Objective Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS. Design We conducted a phase 3, multicentre, tertiary setting, randomised, double-blind, placebo-controlled trial in patients with Rome III confirmed IBS. Patients were randomly assigned to either mesalazine, 800 mg, or placebo, three times daily for 12 weeks, and were followed for additional 12 weeks. The primary efficacy endpoint was satisfactory relief of abdominal pain/discomfort for at least half of the weeks of the treatment period. The key secondary endpoint was satisfactory relief of overall IBS symptoms. Supportive analyses were also performed classifying as responders patients with a percentage of affirmative answers of at least 75% or >75% of time. Results A total of 185 patients with IBS were enrolled from 21 centres. For the primary endpoint, the responder patients were 68.6% in the mesalazine group versus 67.4% in the placebo group (p=0.870; 95% CI −12.8 to 15.1). In explorative analyses, with the 75% rule or >75% rule, the percentage of responders was greater in the mesalazine group with a difference over placebo of 11.6% (p=0.115; 95% CI −2.7% to 26.0%) and 5.9% (p=0.404; 95% CI −7.8% to 19.4%), respectively, although these differences were not significant. For the key secondary endpoint, overall symptoms improved in the mesalazine group and reached a significant difference of 15.1% versus placebo (p=0.032; 95% CI 1.5% to 28.7%) with the >75% rule. Conclusions Mesalazine treatment was not superior than placebo on the study primary endpoint. However, a subgroup of patients with IBS showed a sustained therapy response and benefits from a mesalazine therapy. Trial registration number ClincialTrials.gov number, NCT00626288.
Sphingosine Kinase Type 1 Induces G12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors*

Sphingosine 1-phosphate (S1P) is the ligand for a family of specific G protein-coupled receptors (GPCRs) that regulate a wide variety of important cellular functions, including growth, survival, cytoskeletal rearrangements, and cell motility. However, whether it also has an intracellular function is still a matter of great debate. Overexpression of sphingosine kinase type 1, which generated S1P, induced extensive stress fibers and impaired formation of the Src-focal adhesion kinase signaling complex, with consequent aberrant focal adhesion turnover, leading to inhibition of cell locomotion. We have dissected biological responses dependent on intracellular S1P from those that are receptor-mediated by specifically blocking signaling of Gαq, Gαi, Gα12/13, and Gβγ subunits, the G proteins that S1P receptors (S1PRs) couple to and signal through. We found that intracellular S1P signaled “inside out” through its cell-surface receptors linked to G12/13-mediated stress fiber formation, important for cell motility. Remarkably, cell growth stimulation and suppression of apoptosis by endogenous S1P were independent of GPCRs and inside-out signaling. Using fibroblasts from embryonic mice devoid of functional S1PRs, we also demonstrated that, in contrast to exogenous S1P, intracellular S1P formed by overexpression of sphingosine kinase type 1 promoted growth and survival independent of its GPCRs. Hence, exogenous and intracellularly generated S1Ps affect cell growth and survival by divergent pathways. Our results demonstrate a receptor-independent intracellular function of S1P, reminiscent of its action in yeast cells that lack S1PRs.