Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Public Concern for Information Privacy on the Adoption of Health Information Exchanges (HIEs) by Healthcare Entities

ABSTRACT The implementation of Health Information Exchanges (HIEs) by healthcare organizations may not achieve the desired outcomes as consumers may request that their health information remains unshared because of information privacy concerns. Drawing on the insights of concern for information privacy (CFIP) literature, this work extends the application of CFIP to the HIE domain. This study attempts to develop and test a model centered on the four dimensions of CFIP construct (collection, errors, unauthorized access, and secondary use) and their antecedents to predict consumers’ opt-in behavioral intention toward HIE in the presence of the perceived health status’ effects. We conducted an online survey in the United States using 826 samples. The results demonstrate that the perceived health information sensitivity and computer anxiety meaningfully contribute to information privacy concerns and CFIP construct significantly impedes consumers’ opt-in decision to HIEs. Interestingly, contrary to our expectation, perceived poor health status considerably attenuates the negative effects exerted by CFIP on opt-in intention. The model proposed by this study can be used as a useful conceptual tool by both further studies and practitioners to examine the complex nature of patients’ reactions to information privacy threats associated with the use of HIE technology in the healthcare industry.
Species Differences in the Pharmacokinetic Parameters of Cytochrome P450 Probe Substrates between Experimental Animals, such as Mice, Rats, Dogs, Monkeys, and Microminipigs, and Humans

To clarify species differences in the pharmacokinetic parameters of cytochrome P450 (CYP) activities between humans and experimental animals, we assessed several CYP activities in mice, rats, dogs, monkeys, and microminipigs, using the simultaneous administration of typical human CYP substrates, such as caffeine (human CYP1A2 substrate), losartan (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), and midazolam (CYP3A), to these animals. The intrinsic clearance (CLint) of these 5 substrates was also examined using the liver microsomes of humans and the experimental animals. The high bioavailabilities (BAs) and low CLint values of caffeine in the experimental animals were similar to those in humans. Mice and monkeys had lower BAs and higher CLint values of losartan than those in humans. Mice, rats, and monkeys had lower BAs and higher CLint values of omeprazole than those in humans. The lowest BAs of dextromethorphan were observed in monkeys and microminipigs, and only the CLint in dogs was similar to that in humans. The BA of midazolam in microminipigs only was similar to that in humans, while the CLint values in the other animals were similar to that in humans. These results indicated that in vitro and in vivo experimental data obtained using multiple animals including microminipigs are useful for predicting human pharmacokinetics.
Porphyromonas gingivalis induced periodontitis exacerbates progression of non‐alcoholic steatohepatitis in rats

Non‐alcoholic steatohepatitis (NASH) is a chronic liver disease that can develop into hepatocirrhosis and hepatic carcinoma. In recent years, epidemiological and animal studies have reported that Porphyromonas gingivalis (P. gingivalis), a known periodontopathic bacteria, is closely related to NASH. However, previous studies could not demonstrate a direct relationship between periodontitis, P. gingivalis infection, and NASH. The purpose of the present study was to examine the impact of P. gingivalis‐associated periodontitis on the onset and progression of NASH. Forty‐two male Wistar rats were used in this study. Rats were fed a high‐fat diet (HFD) for 12 weeks in order to induce fatty liver. At 4 weeks from the start of feeding, the animals were performed ligature placement around the maxillary first molar tooth in order to induce experimental periodontitis, and then a P. gingivalis slurry was applied around the ligature twice in a week for 8 weeks (HFD/Pg(+) group). Controls were given the slurry without P. gingivalis after ligature placement using the same protocol (HFD/Pg(−) group). Significant increases in alveolar bone resorption and inflammation in periodontal tissue around the molar tooth in the HFD/Pg(+) group were observed when compared with the HFD/Pg(−) group. Moreover, histological images showing NASH characterized by perivenular lipid deposition including big fatty drops, ballooning degeneration, and focal necrosis with inflammatory cells were confirmed in the liver of rats in the HFD/Pg(+) group. Significant increases in alanine aminotransaminase, aspartate aminotransferase, and C‐reactive protein levels were observed in the HFD/Pg(+) group. Furthermore, endotoxin levels in serum in the HFD/Pg(+) group were significantly higher than those in the HFD/Pg(−) group. The present study demonstrated that experimental periodontitis induced by P. gingivalis led to the progression of NASH in rats with fatty liver. Increased levels of endotoxin derived from P. gingivalis infection appear to play a considerable role in the progression of NASH.
Low-Latency Human Action Recognition with Weighted Multi-Region Convolutional Neural Network

Spatio-temporal contexts are crucial in understanding human actions in videos. Recent state-of-the-art Convolutional Neural Network (ConvNet) based action recognition systems frequently involve 3D spatio-temporal ConvNet filters, chunking videos into fixed length clips and Long Short Term Memory (LSTM) networks. Such architectures are designed to take advantage of both short term and long term temporal contexts, but also requires the accumulation of a predefined number of video frames (e.g., to construct video clips for 3D ConvNet filters, to generate enough inputs for LSTMs). For applications that require low-latency online predictions of fast-changing action scenes, a new action recognition system is proposed in this paper. Termed "Weighted Multi-Region Convolutional Neural Network" (WMR ConvNet), the proposed system is LSTM-free, and is based on 2D ConvNet that does not require the accumulation of video frames for 3D ConvNet filtering. Unlike early 2D ConvNets that are based purely on RGB frames and optical flow frames, the WMR ConvNet is designed to simultaneously capture multiple spatial and short term temporal cues (e.g., human poses, occurrences of objects in the background) with both the primary region (foreground) and secondary regions (mostly background). On both the UCF101 and HMDB51 datasets, the proposed WMR ConvNet achieves the state-of-the-art performance among competing low-latency algorithms. Furthermore, WMR ConvNet even outperforms the 3D ConvNet based C3D algorithm that requires video frame accumulation. In an ablation study with the optical flow ConvNet stream removed, the ablated WMR ConvNet nevertheless outperforms competing algorithms.
Mixed Bundling in Retail DVD Sales: Facts and Theories

Many DVD titles are sold in retail stores in bundles, typically a bundle of two different titles with common characteristics: same lead actor/actress, same director, same genre, etc. This suggests that consumer valuations are positively correlated across the bundle components, which in turn runs counter to the received wisdom that bundling is most profitable when valuations are negatively correlated. In this paper, we propose a solution to this puzzle, one that is based on the observation that DVDs are sequentially released durable goods. At the time the second title is released, it is likely that high-valuation buyers will have bought the first one. For this reason, even though ex-ante valuations are positively correlated, ex-post -- that is, at the time the second title is released -- valuations are negatively correlated. We provide sufficient conditions such that mixed bundling increases revenues and the revenue increase is greater the more positively correlated valuations are. We also provide empirical confirmation of this prediction as well as an independent estimate from a calibrated analytical model.
De novo and inherited private variants in MAP1B in periventricular nodular heterotopia

Periventricular nodular heterotopia (PVNH) is a malformation of cortical development commonly associated with epilepsy. We exome sequenced 202 individuals with sporadic PVNH to identify novel genetic risk loci. We first performed a trio-based analysis and identified 219 de novo variants. Although no novel genes were implicated in this initial analysis, PVNH cases were found overall to have a significant excess of nonsynonymous de novo variants in intolerant genes (p = 3.27x10-7), suggesting a role for rare new alleles in genes yet to be associated with the condition. Using a gene-level collapsing analysis comparing cases and controls, we identified a genome-wide significant signal driven by four ultra-rare loss-of-function heterozygous variants in MAP1B, including one de novo variant. In at least one instance, the MAP1B variant was inherited from a parent with previously undiagnosed PVNH. The PVNH was frontally predominant and associated with perisylvian polymicrogyria. These results implicate MAP1B in PVNH. More broadly, our findings suggest that detrimental mutations likely arising in immediately preceding generations with incomplete penetrance may also be responsible for some apparently sporadic diseases.
Aggression in Humans Correlates With Cerebrospinal

Cerebrospinal fluid levels of the major central metabolites of serotonin (5HT), norepinephrine (NE), and dopamine (DA)-5-hydroxyindoleacetic acid (5H IAA), 3-methoxy-4-hydroxy-phenylglycol (M H PG), and homovanillic acid (HVA), respectively-were studied in a group of 26 age-similar military men with no history of major psychiatric illness, but with various personality disorders and difficulties adjusting to military life. Independently scored history of aggressive behavior showed a significant negative correlation with SHIAA (r = -0.78) and a significant positive correlation with MHPG (r = 0.64). The hypothesis that biological and genetic factors contribute to some forms of aggressive behavior in man is supported by family and twin studies (Hutchings and Mednick, 1975; Robins, 1966), increased criminality in adoptees with criminal biolog- ical fathers (Mednick and Hutchings, 1978), and XYY chromosomal studies (Baker, 1972). A number of animal studies suggest a role for biogenic amines in aggressive behavior (Eichelman, 1973; Eichelman and Thoa, 1973; West, 1977). Direct evalua- tion of brain amine function in man can be approached by assessment of amine metabolites in the cerebrospinal fluid (CSF). In this study we examine the major central metabolites of serotonin (5HT), norepinephrine (NE), and dopamine (DA)- 5-hydroxyindoleactic acid (SHIAA), 3-methoxy-4-hydroxy-phenylglycol (MHPG), and homovanillic acid (HVA), respectively-in the CSF of 26 men with varied life histories of aggressive, violent, and impulsive behavior. The significance of neuro- transmitter metabolites in CSF for human psychiatric and behavioral studies has been extensively reviewed by Goodwin et al. (1977). '
Library Not Found - The Disconnect between Gaming Research and Development

Video games clearly have great educational potential, both for formal and informal learning, and this avenue is being thoroughly investigated in the psychology and education literature. However, there appears to be a disconnect between social science academic research and the game development sector, in that research and development practices rarely inform each other. This paper presents a two-part analysis of this communicative disconnect based on investigations carried out within the H2020 Gaming Horizons project. The first part regards a literature review that identified the main topics of focus in the social sciences literature on games, as well as the chief recommendations authors express. The second part examines 73 interviews with 30 developers, 14 researchers, 13 players, 12 educators, and 4 policy makers, investigating how they perceived games and gaming. The study highlights several factors contributing to the disconnect: different priorities and dissemination practices; the lag between innovation in the games market and research advancements; low accessibility of academic research; and disproportionate academic focus on serious games compared to entertainment games. The authors suggest closer contact between researchers and developers might be sought by diversifying academic dissemination channels, promoting conferences involving both groups, and developing research partnerships with entertainment game companies.
Rac1 muscle knockout exacerbates the detrimental effect of high‐fat diet on insulin‐stimulated muscle glucose uptake independently of Akt

The actin cytoskeleton regulating GTPase, Rac1, is a novel player in insulin-stimulated glucose uptake in muscle in vivo. High‐fat diet (HFD) exacerbates muscle insulin resistance in Rac1 muscle knockout (mKO) mice. Muscle Rac1 KO protects against HFD‐induced insulin resistance in fat tissue indicating tissue cross‐talk. A fatty diet markedly reduces insulin clearance in mice.
The Effects of Structured Transfer Pathways in Community Colleges

Most of the students who set out to earn degrees in community colleges never do. Interventions that simplify the complex organizational structures of these schools are promising solutions to this problem. This article is the first to provide rigorous evidence of the effects of structured transfer programs, one such intervention. Leveraging the phased rollout of transfer programs in California, I find large effects of the policy on degrees earned in treated departments. In the first 2 years, this growth was not coupled with growth in total degrees granted or in transfers, but in the third year, there is evidence of increased transfer. The analyses also show that the policy could affect equity; departments that offer transfer degrees became more popular and there is suggestive evidence that the highest achieving student groups enrolled in these classes at higher rates.
Mining Temporal Information to Improve Duplication Detection on Bug Reports

Due to the vast amount of bug reports in many large-scale open source projects, detecting duplicate reports has received much attention in recent years. Textual information and different kinds of categorical information have been leveraged in many detection methods. Although past studies have shown the influence of the temporal information in the submission interval of duplicate bug reports, only few methods consider the temporal information in its plain interval form. In this paper, we propose a temporal model to improve the detection performance by considering the submission time and the version information. We discuss the effectiveness by implementing it based on a prestigious BM25Fext-based method. Empirical experiments have been conducted on a dataset collected from the Eclipse open source project. Compared with the baseline BM25Fext-based method, the proposed scheme can obtain performance improvement consistently.
Prevalence and Risk of Vertebral Fractures in Primary Hyperparathyroidism: A Nested Case‐Control Study

Prevalence of vertebral fractures (VFx) in primary hyperparathyroidism (PHPT) remains uncertain. We aimed to estimate the prevalence of VFx, investigate potential risk factors associated with VFx, and whether bone mineral density (BMD) differs between PHPT and osteoporotic patients with VFx. Through the Danish National Patient Register, we identified patients diagnosed with PHPT from 2005 to 2015. The diagnosis was verified by reviewing biochemical findings, and X‐ray reports were reviewed by two investigators. Osteoporotic patients with VFx were identified from our outpatient clinic and matched on age and sex with PHPT patients with VFx. We identified 792 PHPT patients among whom spine X‐ray was available from 588 patients. VFx were present in 122 (21%) patients and were equally frequent among sexes (77% females). Fractured patients were older (70 versus 63 years) and had lower heights (163 versus 166 cm) compared with nonfractured patients (p all < 0.02). After stratification by age groups, the prevalence of VFx differed significantly between sexes (p < 0.01). Ionized calcium and parathyroid hormone did not differ between groups. BMD at total hip and forearm were lower in fractured compared with nonfractured patients (p < 0.03 for both) after adjusting for age, sex, and body mass index (BMI). Compared with osteoporotic patients with VFx (n = 108), BMD at the lumbar spine was higher in PHPT patients with VFx (n = 108) (p < 0.01). This did not change by excluding patients with lumbar VFx (p < 0.01). The severity of PHPT assessed by biochemistry does not seem to be associated with risk of VFx. Compared with osteoporosis, VFx seems to occur at a higher BMD in PHPT. © 2018 American Society for Bone and Mineral Research.
More About When I’s Meet: The Intergroup Ramifications of I-Sharing, Part II

Previous research on I-sharing (the belief that one has shared the same, in-the-moment subjective experience with another person) revealed its promise for improving intergroup relations. We expand on this research by (a) pursuing the mechanism underlying I-sharing’s effects; (b) asking whether I-sharing promotes positive, behavioral intergroup outcomes; and (c) asking whether the effects of I-sharing generalize to the outgroup at large. Study 1 rules out the possibility that I-sharing promotes liking for an outgroup member via a process of subtyping. Study 2 shows that I-sharing promotes liking for an outgroup member because it promotes a general feeling of subjective connection to the I-sharer. Study 3 provides evidence that I-sharing promotes helping across intergroup lines, and Study 4 shows that I-sharing with one outgroup member reduces infrahumanization of the outgroup more generally. These four studies contribute to our growing understanding of the unique impact that I-sharing has on intergroup outcomes.
Delinquent girls' descriptions of prior, current, and future selves and the relationship of self descriptions to prior adversities and current illegal and prosocial behavior

DELINQUENT GIRLS’ DESCRIPTIONS OF PRIOR, CURRENT, AND FUTURE SELVES AND THE RELATIONSHIP OF SELF DESCRIPTIONS TO PRIOR ADVERSITIES AND CURRENT ILLEGAL AND PROSOCIAL BEHAVIOR By Marva V. Goodson Delinquent girls have recently grabbed the attention of researchers due to their larger proportional representation of youth under supervision in juvenile courts. Among other influences, delinquency is commonly examined as the result of family dysfunction, negative peer relations, and low academic commitment. However, this approach provides limited insight into the internal struggles of girls who are deeply enmeshed in the juvenile justice system. Literature examining the self perceptions of delinquent girls, as they tackle physical and emotional development during adolescence, is limited. Specifically, little is known about the way in which self perception changes among girls as they desist from criminality and transition into adulthood. The current study explores retrospective perceptions of prior self, current self, and the attainability of positive future self of a sample of 27 girls deeply enmeshed in the juvenile justice system. Self perceptions are examined under the theoretical framework of McAdam’s (1985) Narrative Identity Theory. Identifiers of self perception, gained from the qualitative interviews, are examined in relation to delinquency, adversity, and prosocial behaviors. Findings suggest that girls are increasingly positive about their self perceptions over time and different types of adversity have varying impacts on girls’ perceived attainability of a positive future self. Copyright by Marva V. Goodson 2014
Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses

Significance Excitatory synapses convert presynaptic action potentials into chemical signals that are sensed by postsynaptic glutamate receptors. To eavesdrop on synaptic transmission, genetically encoded fluorescent sensors for glutamate have been developed. However, even the best available sensors lag behind the very fast glutamate dynamics in the synaptic cleft. Here, we report the development of an ultrafast genetically encoded glutamate sensor, iGluu, which allowed us to image glutamate clearance and synaptic depression during 100-Hz spike trains. We found that only boutons showing paired-pulse facilitation were able to rapidly recover from depression. Thus, presynaptic boutons act as frequency-specific filters to transmit select features of the spike train to specific postsynaptic cells. Glutamatergic synapses display a rich repertoire of plasticity mechanisms on many different time scales, involving dynamic changes in the efficacy of transmitter release as well as changes in the number and function of postsynaptic glutamate receptors. The genetically encoded glutamate sensor iGluSnFR enables visualization of glutamate release from presynaptic terminals at frequencies up to ∼10 Hz. However, to resolve glutamate dynamics during high-frequency bursts, faster indicators are required. Here, we report the development of fast (iGluf) and ultrafast (iGluu) variants with comparable brightness but increased Kd for glutamate (137 μM and 600 μM, respectively). Compared with iGluSnFR, iGluu has a sixfold faster dissociation rate in vitro and fivefold faster kinetics in synapses. Fitting a three-state model to kinetic data, we identify the large conformational change after glutamate binding as the rate-limiting step. In rat hippocampal slice culture stimulated at 100 Hz, we find that iGluu is sufficiently fast to resolve individual glutamate release events, revealing that glutamate is rapidly cleared from the synaptic cleft. Depression of iGluu responses during 100-Hz trains correlates with depression of postsynaptic EPSPs, indicating that depression during high-frequency stimulation is purely presynaptic in origin. At individual boutons, the recovery from depression could be predicted from the amount of glutamate released on the second pulse (paired pulse facilitation/depression), demonstrating differential frequency-dependent filtering of spike trains at Schaffer collateral boutons.
Simultaneity and Temporal Order Judgments Are Coded Differently and Change With Age: An Event-Related Potential Study

Multisensory integration is required for a number of daily living tasks where the inability to accurately identify simultaneity and temporality of multisensory events results in errors in judgment leading to poor decision-making and dangerous behavior. Previously, our lab discovered that older adults exhibited impaired timing of audiovisual events, particularly when making temporal order judgments (TOJs). Simultaneity judgments (SJs), however, were preserved across the lifespan. Here, we investigate the difference between the TOJ and SJ tasks in younger and older adults to assess neural processing differences between these two tasks and across the lifespan. Event-related potentials (ERPs) were studied to determine between-task and between-age differences. Results revealed task specific differences in perceiving simultaneity and temporal order, suggesting that each task may be subserved via different neural mechanisms. Here, auditory N1 and visual P1 ERP amplitudes confirmed that unisensory processing of audiovisual stimuli did not differ between the two tasks within both younger and older groups, indicating that performance differences between tasks arise either from multisensory integration or higher-level decision-making. Compared to younger adults, older adults showed a sustained higher auditory N1 ERP amplitude response across SOAs, suggestive of broader response properties from an extended temporal binding window. Our work provides compelling evidence that different neural mechanisms subserve the SJ and TOJ tasks and that simultaneity and temporal order perception are coded differently and change with age.