Miracle-dz/UniFAR-FTUs huggingface dataset:
Protein Expression of PTEN, Insulin-Like Growth Factor I Receptor (IGF-IR), and Lethal Prostate Cancer: A Prospective Study

Background: Loss of PTEN has been shown to be associated with aggressive behavior of prostate cancer. It is less clear that loss of PTEN also increases the risk of cancer mortality. We investigated the association between PTEN expression and prostate cancer mortality and the potential effect modification by IGF-IR, a direct activator of the phosphoinositide-3-kinase (PI3K) pathway. Methods: Protein expression in tumor was evaluated using tumor tissues obtained from 805 participants of the Physicians' Health and the Health Professionals Follow-up studies who were diagnosed with prostate cancer and underwent radical prostatectomy. Proportional hazard models were used to assess PTEN expression and its interaction with IGF-IR, in relation to lethal prostate cancer (cancer-specific death or distant metastases). Results: Low PTEN expression was associated with an increased risk of lethal prostate cancer [HR, 1.7; 95% confidence interval (CI), 0.98–3.2; Ptrend = 0.04]. The association was attenuated after adjustment for Gleason grade, tumor stage, and prostate-specific antigen (PSA) at diagnosis. A significant negative interaction between PTEN and IGF-IR was found (Pinteraction = 0.03). Either reduction in PTEN or increase in IGF-IR expression was sufficient to worsen prognosis. Models including PTEN and IGF-IR expression offer additional predicting power to prostate cancer survival, compared to those only including demographic and clinical factors. Conclusions: Low PTEN protein expression significantly increases the risk of lethal prostate cancer, particularly when the IGF-IR expression remains at normal level. Impact: PTEN and IGF-IR expression in tumor are promising candidates for independent prognostic factors to predict lethal prostate cancer. Cancer Epidemiol Biomarkers Prev; 22(11); 1984–93. ©2013 AACR.
The Impact of Technology on Creativity in Design: An Enhancement?

Technology may be considered as an interface between individuals and the products they create, but we have to determine whether the use of new systems effectively enhance individuals' creative activities. In this paper, we present a new angle of reflection that we illustrate in the field of creative design, since it is a constant challenge for designers to introduce creativity in the projects they work on. The approach we propose is centred on designers' cognitive processes. We argue that both the development of new CAD (computer-aided design) systems and their assessment should be conducted on the basis of a deep understanding of designers' cognitive processes. In accordance with this view, we present three empirical studies that were conducted in order to analyse the impact of new design support systems on designers' cognitive processes. Therefore, the results we present contribute to further our knowledge of whether new CAD technologies effectively facilitate designers' activities and enhance their creativity.
Neural Correlates of Recency Judgment

The prefrontal cortex plays a critical role in recollecting the temporal context of past events. The present study used event-related functional magnetic resonance imaging (fMRI) and explored the neural correlates of temporal-order retrieval during a recency judgment paradigm. In this paradigm, after study of a list of words presented sequentially, subjects were presented with two of the studied words simultaneously and were asked which of the two words was studied more recently. Two types of such retrieval trials with varied (high and low) levels of demand for temporal-order retrieval were intermixed and compared using event-related fMRI. The intraparadigm comparison of high versus low demand trials revealed brain regions with activation that was modulated on the basis of demand for temporal-order retrieval. Multiple lateral prefrontal regions including the middle and inferior lateral prefrontal cortex were prominently activated. Activation was also observed in the anterior prefrontal cortex and the medial temporal cortex, regions well documented to be related to memory retrieval in general. The modulation of brain activity in these regions suggests a detailed pathway that is engaged during recency judgment.
On the performance of complexity-optimized bilayer lengthened LDPC codes for relay channels

In this paper, we design an extended class of complexity-optimized bilayer lengthened low-density parity-check (LDPC) codes by considering upper check nodes with different degrees. We show that by implementing a low complexity relay decoder, our designed codes outperform the rate-optimized codes in a wide range of Eb/N0's.
BDD Ordering Heuristics for Classical Planning

Symbolic search using binary decision diagrams (BDDs) can often save large amounts of memory due to its concise representation of state sets. A decisive factor for this method's success is the chosen variable ordering. Generally speaking, it is plausible that dependent variables should be brought close together in order to reduce BDD sizes. In planning, variable dependencies are typically captured by means of causal graphs, and in preceding work these were taken as the basis for finding BDD variable orderings. Starting from the observation that the two concepts of "dependency" are actually quite different, we introduce a framework for assessing the strength of variable ordering heuristics in sub-classes of planning. It turns out that, even for extremely simple planning tasks, causal graph based variable orders may be exponentially worse than optimal. Experimental results on a wide range of variable ordering variants corroborate our theoretical findings. Furthermore, we show that dynamic reordering is much more effective at reducing BDD size, but it is not cost-effective due to a prohibitive runtime overhead. We exhibit the potential of middle-ground techniques, running dynamic reordering until simple stopping criteria hold.
Ownership Concentration and Firm Value: A Study from the Indian Corporate Sector

This paper contributes to understanding corporate governance issues in emerging economies by examining how blockholders influence firm value. Using a much disaggregated and uniform database from the Indian corporate sector for the year 2001, we examine the interaction between ownership structure and firm value in the following ways. Unlike most existing research, which studies the aggregate level of ownership, we include a wider set of mechanisms, such as identity and ownership concentration of outside blockholders controlling at least 5 percent of total equity of the firm. We analyze the role played by these shareholders with substantial voting power in situations when equity holding is less compared to the more concentrated holdings of promoters. We also attempt to see if these investors coordinate among themselves to constrain insiders from expropriating corporate resources. We find a significant curvilinear relationship between firm value and the fraction of voting rights owned by insiders. The curve slopes downward until insider ownership reaches approximately between 45 percent and 63 percent, then slopes upward. Empirical results on ownership concentration by minority blockholders do not support the monitoring hypothesis of these investors. Furthermore, the coordinated behavior of the largest two minority blockholders has an increasing (decreasing) impact on firm value when the collective control is located in the lower (higher) range. The coordination problem worsens if the largest two are private corporate bodies.
Double-blind, placebo-controlled study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder.

OBJECTIVE To evaluate the efficacy and safety of 30, 50, and 70 mg/day lisdexamfetamine dimesylate compared with placebo in adults with attention-deficit/hyperactivity disorder (ADHD). METHOD Following a 7- to 28-day washout, 420 adults aged 18 to 55 years with moderate to severe ADHD (DSM-IV-TR criteria) were treated with 30, 50, or 70 mg/day lisdexamfetamine or placebo, respectively, for 4 weeks (N = 119, 117, 122, and 62, respectively). The 50- and 70- mg/day groups underwent forced-dose titration. The primary efficacy measure was the clinician-determined ADHD Rating Scale (ADHD-RS) total score. The study was conducted from May 2006 to November 2006. RESULTS Treatment groups were well matched at baseline, including in ADHD-RS scores. At endpoint, changes in ADHD-RS scores were significantly greater for each lisdexamfetamine dose than for placebo (placebo = -8.2, 30 mg/day lisdexamfetamine = -16.2, 50 mg/day lisdexamfetamine = -17.4, 70 mg/day lisdexamfetamine = -18.6; all p < .0001 vs. placebo), with no differences between doses. Significant differences relative to placebo were observed in each lisdexamfetamine group, beginning at week 1 and for each week throughout. The percentage of subjects who improved (Clinical Global Impressions-Improvement scale rating < or = 2) was significantly greater for each lisdexamfetamine dose than for placebo at each week and at endpoint (placebo = 29%, 30 mg/day lisdexamfetamine = 57%, 50 mg/day lisdexamfetamine = 62%, 70 mg/day lisdexamfetamine = 61%; all p < .01). Adverse events were generally mild and included dry mouth, decreased appetite, and insomnia. CONCLUSION All 3 lisdexamfetamine doses were significantly more effective than placebo in the treatment of adults with ADHD, with improvements noted within 1 week. Lisdexamfetamine was generally well tolerated by these patients.
Myosin Va Increases the Efficiency of Neurofilament Transport by Decreasing the Duration of Long-Term Pauses

We investigated the axonal transport of neurofilaments in cultured neurons from two different strains of dilute lethal mice, which lack myosin Va. To analyze the motile behavior, we tracked the movement of green fluorescent protein (GFP)-tagged neurofilaments through naturally occurring gaps in the axonal neurofilament array of cultured superior cervical ganglion neurons from DLS/LeJ dilute lethal mice. Compared with wild-type controls, we observed no statistically significant difference in velocity or frequency of movement. To analyze the pausing behavior, we used a fluorescence photoactivation pulse–escape technique to measure the rate of departure of PAGFP (photoactivatable GFP)-tagged neurofilaments from photoactivated axonal segments in cultured dorsal root ganglion neurons from DLS/LeJ and dl20J dilute lethal mice. Compared with wild-type controls, we observed a 48% increase in the mean time for neurofilaments to depart the activated regions in neurons from DLS/LeJ mice (p < 0.001) and a 169% increase in neurons from dl20J mice (p < 0.0001). These data indicate that neurofilaments pause for more prolonged periods in the absence of myosin Va. We hypothesize that myosin Va is a short-range motor for neurofilaments and that it can function to enhance the efficiency of neurofilament transport in axons by delivering neurofilaments to their microtubule tracks, thereby reducing the duration of prolonged off-track pauses.
The Estate Tax and After-Tax Investment Returns

This paper explores the effect of estate and gift taxes on the after-tax rate of return earned by savers. The estate tax affects only a small fraction of households -- taxable decedents represented only 1.4 percent of all deaths in 1995 -- but the affected households account for a substantial fraction of household net worth. The estate tax can be viewed as a tax on capital income, with the effective rate depending on the statutory tax rate as well as the potential taxpayer's mortality risk. Because mortality rates rise with age, the effective estate tax burden is therefore greater for older than for younger individuals. The estate tax adds approximately 0.3 percentage points to the average tax burden on capital income for households headed by individuals between the ages of 50 and 59. For households headed by individuals between the ages of 70 and 79, however, the estate tax increases the tax burden on capital income by approximately 3 percentage points. The effects are even larger for older households. The paper also explores the fraction of the net worth held by households that are subject to the estate tax that could be transferred to the next generation with a program a per donee exemption from gift tax. While roughly one quarter of potentially taxable assets could be transferred in this way, actual levels of inter vivos giving are much lower than the levels that would one would expect if households were taking full advantage of this tax avoidance strategy.
Financial Asset Pricing Theory

Financial Asset Pricing Theory offers a comprehensive overview of the classic and the current research in theoretical asset pricing. Asset pricing is developed around the concept of a state-price deflator which relates the price of any asset to its future (risky) dividends and thus incorporates how to adjust for both time and risk in asset valuation. The willingness of any utility-maximizing investor to shift consumption over time defines a state-price deflator which provides a link between optimal consumption and asset prices that leads to the Consumption-based Capital Asset Pricing Model (CCAPM). A simple version of the CCAPM cannot explain various stylized asset pricing facts, but these asset pricing 'puzzles' can be resolved by a number of recent extensions involving habit formation, recursive utility, multiple consumption goods, and long-run consumption risks. Other valuation techniques and modelling approaches (such as factor models, term structure models, risk-neutral valuation, and option pricing models) are explained and related to state-price deflators. The book will serve as a textbook for an advanced course in theoretical financial economics in a PhD or a quantitative Master of Science program. It will also be a useful reference book for researchers and finance professionals. The presentation in the book balances formal mathematical modelling and economic intuition and understanding. Both discrete-time and continuous-time models are covered. The necessary concepts and techniques concerning stochastic processes are carefully explained in a separate chapter so that only limited previous exposure to dynamic finance models is required.
The Inflation Target Five Years On

Mervyn King is the Deputy Governor of the Bank of England and a co-founder of the LSE Financial Markets Group. On Wednesday 29 October 1997 he gave a public lecture at the LSE to mark the 10th anniversary of the Financial Markets Group and the 5th annivesay of the Bank of England Inflation Target. This Special Paper is the Transcript of that lecture.
Effects of first and second language on segmentation of non-native speech*

Do Slovak–German bilinguals apply native Slovak phonological and lexical knowledge when segmenting German speech? When Slovaks listen to their native language, segmentation is impaired when fixed-stress cues are absent (Hanulíková, McQueen & Mitterer, 2010), and, following the Possible-Word Constraint (PWC; Norris, McQueen, Cutler & Butterfield, 1997), lexical candidates are disfavored if segmentation leads to vowelless residues, unless those residues are existing Slovak words. In the present study, fixed-stress cues on German target words were again absent. Nevertheless, in support of the PWC, both German and Slovak listeners recognized German words (e.g., Rose “rose”) faster in syllable contexts (suckrose) than in single-consonant contexts (krose, trose). But only the Slovak listeners recognized, for example, Rose faster in krose than in trose (k is a Slovak word, t is not). It appears that non-native listeners can suppress native stress segmentation procedures, but that they suffer from prevailing interference from native lexical knowledge.
An Econometric Model of Tourist Demand

Abstract Tourism today includes a wide array of economic and social activities on an international scale and covers all social classes. It is directly related with the development of every modern society and aims at meeting human needs in a developed culture so as to create the conditions for advancing understanding and kinship among the different peoples in order to achieve a better future for mankind. The tourism sector does not constitute a specific sector in an economy, but includes goods and services from various sectors. The present study focuses on foreign tourism due to its primary influence on changes made in the social and economic structure of the tourist-host country. This study employs an econometric model of tourist demand in a developed tourist market such as that in Greece which aims to improve its tourist product.
Communication Privacy Management in College Athletics: Exploring Privacy Dilemmas in the Athletic/Academic Advisor Student-Athlete Interpersonal Relationship

The purpose of the present study was to explore how athletic/academic advisors communicatively managed privacy boundaries with college student-athletes. The researcher interviewed 37 athletic/academic advisors to address one central research question: What type of dilemmas do athletic/academic advisors experience when managing the privacy boundary surrounding student-athletes’ private information? Athletic/academic advisors who were interviewed represented 21 different institutions of four different NCAA division levels (i.e., I, IAA, II, and III), and more than 10 separate NCAA athletic conferences. Findings indicated that athletic/academic advisors experienced different types of dilemmas which revolved around private information student-athletes disclosed regarding academic, athletic, and personal issues. This research presents specific dilemmas advisors experienced. Practical applications as well as directions for future research are also discussed.
GENERAL ELK BOW SEASONS

Beatys Butte, Beulah, Biggs, Catherine Creek, Columbia Basin, E Fort Rock (that portion east of Hwy 97), Fossil, Grizzly, Hood, Imnaha, Juniper, Lookout Mt, Malheur Rvr, Maupin, Murderers Cr, Northside, Owhyee, Paulina, Pine Cr, Ritter portion of the Heppner Unit (that part of 48 south and east of N Fork John Day Rvr.), Silvies, Steens Mt, S Sumpter (see page 73), Wagontire, White Rvr, and Whitehorse units EXCEPTIONS: ■ Ochoco and Sled Springs units are closed to deer and elk bowhunting unless the hunter has a controlled elk bow tag for the respective unit. ■ Steens Mt Unit is closed to deer and elk bowhunting unless the hunter has a controlled deer bow tag for the respective unit. ■ Columbia Basin Unit is closed to all bowhunting beginning at Vinson at the intersection of Hwy 74 and Butter Creek Rd, west on Hwy 74 to Sandhollow Rd, north on Sandhollow Rd to Baseline Rd, west half mile to Sandhollow Rd, north on Sandhollow Rd to Hwy 207, north and east on Hwy 207 to Butter Creek Junction, south on Butter Creek Rd to Hwy 74 at Vinson. Desolation, W Fort Rock (that portion west of Hwy 97), Heppner north and west of N John Day Rvr, Interstate, Keating, Keno, Klamath Falls, Maury, Metolius, Minam, Upper Deschutes, Silver Lake, Snake Rvr, Sprague, Starkey, N Sumpter (see page 73), Ukiah, and Warner units. EXCEPTIONS: ■ Starkey Experimental Forest except by controlled elk bow tag. ■ Maury and Warner units are closed to deer and elk bowhunting unless the hunter has a controlled deer bow tag for the respective unit. ■ Chesnimnus Unit is closed to deer and elk bowhunting unless the hunter has a controlled elk bow tag for the unit.
Contrasting Patterns of Transposable Element Insertions in Drosophila Heat-Shock Promoters

The proximal promoter regions of heat-shock genes harbor a remarkable number of P transposable element (TE) insertions relative to both positive and negative control proximal promoter regions in natural populations of Drosophila melanogaster. We have screened the sequenced genomes of 12 species of Drosophila to test whether this pattern is unique to these populations. In the 12 species' genomes, transposable element insertions are no more abundant in promoter regions of single-copy heat-shock genes than in promoters with similar or dissimilar architecture. Also, insertions appear randomly distributed across the promoter region, whereas insertions clustered near the transcription start site in promoters of single-copy heat-shock genes in D. melanogaster natural populations. Hsp70 promoters exhibit more TE insertions per promoter than all other genesets in the 12 species, similarly to in natural populations of D. melanogaster. Insertions in the Hsp70 promoter region, however, cluster away from the transcription start site in the 12 species, but near it in natural populations of D. melanogaster. These results suggest that D. melanogaster heat-shock promoters are unique in terms of their interaction with transposable elements, and confirm that Hsp70 promoters are distinctive in TE insertions across Drosophila.
Solvency Analysis and Prediction in Property–Casualty Insurance: Incorporating Economic and Market Predictors

type="main" xml:lang="en"> This article extends the insolvency prediction literature by incorporating macroeconomic conditions and state-specific factors. The models achieve greater generalizability and predictive accuracy than earlier research while giving fewer false positives. At the firm level, we find insurers with less diversified business, sufficient cash flow, high return on equity, lower leverage, fewer failed Insurance Regulatory Information System ratio tests, and membership in a larger group are less likely to become insolvent. Our findings support the argument that insolvency likelihood increases for insurers domiciled in states with stricter solvency supervision and/or states with less favorable insurance market conditions, and during soft markets; insolvency risk is negatively related to the slope of the yield curve. Our findings also imply that insurers respond efficiently to changes in such market factors as market return, inflation, and catastrophic losses.
What's That Smell? An Ecological Approach to Understanding Preferences for Familiar Odors

How do odor preferences arise? Following Palmer and Schloss's (2010, PNAS, 107, 8877–8882) ecological valence theory of color preferences, we propose that preference for an odor is determined by preferences for all objects and/or entities associated with that odor. The present results showed that preferences for familiar odors were strongly predicted by average preferences for all things associated with the odors (eg people liked the apple odor which was associated with mostly positive things, such as apples, soap, and candy, but disliked the fish odor, which was associated with mostly negative things, such as dead fish, trash, and vomit). The odor WAVEs (weighted affective valence estimates) performed significantly better than one based on preference for only the namesake object (eg predicting preference for the apple odor based on preference for apples). These results suggest that preferences for familiar odors are based on a summary statistic, coding the valence of previous odor-related experiences. We discuss how this account of odor preferences is consistent with the idea that odor preferences exist to guide organisms to approach beneficial objects and situations and avoid harmful ones.