Miracle-dz/UniFAR-FTUs huggingface dataset:
Erlotinib at a Dose of 25 mg Daily for Non-small Cell Lung Cancers with EGFR Mutations

Purpose: The tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib are effective in non-small cell lung cancers (NSCLCs) with epidermal growth factor receptor (EGFR) gene mutations. The usual clinical dose of gefitinib (250 mg/d) is only one third of its maximum tolerated dose, whereas the dose of erlotinib (150 mg/d) is at its maximum tolerated dose. In NSCLC cell lines, both TKIs have similar micromolar inhibitory concentrations. We explored whether erlotinib at 25 mg/d (trough serum concentration similar to gefitinib 250 mg/d) would be efficacious in EGFR-mutated NSCLC. Methods: To study the inhibitory concentrations of gefitinib and erlotinib, we exposed EGFR-mutated cell lines (HCC827, H3255, PC-9, and H1975) to increasing concentrations of these TKIs. Further on, we performed a retrospective evaluation of seven patients with advanced EGFR-mutated (exon 19 deletions and L858R) NSCLC that were given erlotinib at 25 mg/d as their first EGFR TKI. Results: Gefitinib and erlotinib generated similar inhibitory curves across our panel of EGFR-mutated NSCLC cell lines with overlapping mean 50% inhibitory concentration 95% confidence intervals for HCC827, PC-9, and H1975. Both drugs also displayed a high degree of correlation in mean 50% inhibitory concentration (Pearson's r = 0.99, p = 0.0417). Of the seven patients, five patients (71.5%) had partial responses to erlotinib 25 mg/d. Median progression-free survival was 17 months (95% confidence interval, 6–35 months). Toxicities were minimal, with only two (28.5%) patients having a rash and none experiencing (0%) diarrhea. Conclusions: In NSCLC cell lines, gefitinib and erlotinib have similar inhibitory profiles. In patients with NSCLC and EGFR-activating mutations, a dose of erlotinib 25 mg/d (equivalent to gefitinib 250 mg/d) leads to impressive response rates and progression-free survival similar to the growing experience with the approved doses of gefitinib (250 mg/d) and erlotinib (150 mg/d). Identifying prospectively the lowest and clinically active dose ranges of erlotinib and gefitinib will help further to personalize care for patients with tumors harboring EGFR mutations.
Cord blood transplantation for adults

Allogeneic haematopoietic stem cell transplant has become an import tool for the treatment of high risk and advanced haematological diseases. However, allogeneic transplantation has been limited by the availability of suitable related and unrelated donors. The positive results with umbilical cord blood as an alternative source of haematopoietic stem cells for transplantation in the paediatric setting encouraged studies in adult patients. In adults, however, the progress of cord blood transplantation has been slower, in part limited by the limitation of cell dose. We review here the current state of the art on cord blood transplantation for adults, and discuss some of the newer strategies being pursued in order to improve its safety and efficacy.
The evolution of carbon and oxygen in the bulge and disk of the Milky Way

Context. The evolution of C and O abundances in the Milky Way can impose strong constraints on stellar nucleosynthesis and help in understanding the formation and evolution of our Galaxy. Aims. The aim of this paper is to review the measured C and O abundances in the disk and bulge of the Galaxy and compare the results to predictions of Galactic chemical evolution models. Methods. We adopt two successful chemical evolution models for the bulge and the disk, respectively. They assume the same nucleosynthesis prescriptions but different histories of star formation. Results. The data show a clear distinction between the trend of [C/O] in the thick and thin Galactic disks, while the thick disk and bulge trends are indistinguishable with a large (>0.5 dex) increase in the [C/O] ratio in the range from -0.1 to +0.4 dex for [O/H]. In our models we consider yields from massive stars with and without the inclusion of metallicity-dependent stellar winds. The observed increase in the [C/O] with metallicity in the bulge and thick disk lies between the predictions utilizing mass-loss rates of Maeder and Meynet & Maeder. A model without metallicity-dependent yields completely fails to match the observations. Thus, the relative increase in carbon abundance at high metallicity appears to come from metallicity-dependent stellar winds in massive stars. These results also explain the steep decline of the [O/Fe] ratio with [Fe/H] in the Galactic bulge, while the [Mg/Fe] ratio is enhanced at all [Fe/H]. Conclusions. We conclude that data and models are consistent with a rapid bulge and thick disk formation timescales, and with metallicity-dependent yields for C and O. The observed too high [C/O] ratios at low metallicity in the bulge may stem from an unaccounted source of carbon: very fast rotating metal poor stars, or metal-poor binary systems whose envelopes were stripped by Roche lobe overflow.
Air Bag Safety: Media Coverage, Popular Conceptions, and Public Policy

Federal regulation of air bags has followed an uncertain course in recent years; air bags have been perceived as a panacea but are now considered potential killers. The authors examine the interplay of media coverage, lay perceptions of risk, and public policy in the context of air bag regulation. They review communications research on media presentations of health and safety risks and the relationship of these findings to social psychological research on the determinants of perceived risk. Two original studies provide corroborating evidence that national print media depict air bags as riskier than warranted by objective data (Study 1) and that measurable indicators of this bias, when systematically manipulated, influence readers' attitudes toward disconnection of air bags as well as damage awards in a hypothetical tort suit against a car manufacturer (Study 2). Implications of media risk communication for safety regulation are discussed.
FENNEL: streaming graph partitioning for massive scale graphs

Balanced graph partitioning in the streaming setting is a key problem to enable scalable and efficient computations on massive graph data such as web graphs, knowledge graphs, and graphs arising in the context of online social networks. Two families of heuristics for graph partitioning in the streaming setting are in wide use: place the newly arrived vertex in the cluster with the largest number of neighbors or in the cluster with the least number of non-neighbors. In this work, we introduce a framework which unifies the two seemingly orthogonal heuristics and allows us to quantify the interpolation between them. More generally, the framework enables a well principled design of scalable, streaming graph partitioning algorithms that are amenable to distributed implementations. We derive a novel one-pass, streaming graph partitioning algorithm and show that it yields significant performance improvements over previous approaches using an extensive set of real-world and synthetic graphs. Surprisingly, despite the fact that our algorithm is a one-pass streaming algorithm, we found its performance to be in many cases comparable to the de-facto standard offline software METIS and in some cases even superiror. For instance, for the Twitter graph with more than 1.4 billion of edges, our method partitions the graph in about 40 minutes achieving a balanced partition that cuts as few as 6.8% of edges, whereas it took more than 81/2 hours by METIS to produce a balanced partition that cuts 11.98% of edges. We also demonstrate the performance gains by using our graph partitioner while solving standard PageRank computation in a graph processing platform with respect to the communication cost and runtime.
SIMPLIcity: Semantics-Sensitive Integrated Matching for Picture LIbraries

We present here SIMPLIcity (semantics-sensitive integrated matching for picture libraries), an image retrieval system, which uses semantics classification methods, a wavelet-based approach for feature extraction, and integrated region matching based upon image segmentation. An image is represented by a set of regions, roughly corresponding to objects, which are characterized by color, texture, shape, and location. The system classifies images into semantic categories. Potentially, the categorization enhances retrieval by permitting semantically-adaptive searching methods and narrowing down the searching range in a database. A measure for the overall similarity between images is developed using a region-matching scheme that integrates properties of all the regions in the images. The application of SIMPLIcity to several databases has demonstrated that our system performs significantly better and faster than existing ones. The system is fairly robust to image alterations.
Dissociable regulation of instrumental action within mouse prefrontal cortex

Evaluation of the behavioral ‘costs’, such as effort expenditure relative to the benefits of obtaining reward, is a major determinant of goal‐directed action. Neuroimaging evidence suggests that the human medial orbitofrontal cortex (mOFC) is involved in this calculation and thereby guides goal‐directed and choice behavior, but this region’s functional significance in rodents is unknown despite extensive work characterizing the role of the lateral OFC in cue‐related response inhibition processes. We first tested mice with mOFC lesions in an instrumental reversal task lacking discrete cues signaling reinforcement; here, animals were required to shift responding based on the location of the reinforced aperture within the chamber. Mice with mOFC lesions acquired the reversal but failed to inhibit responding on the previously reinforced aperture, while mice with prelimbic prefrontal cortex lesions were unaffected. When tested on a progressive ratio schedule of reinforcement, mice with prelimbic cortical lesions were unable to maintain responding, resulting in declining response levels. Mice with mOFC lesions, by contrast, escalated responding. Neither lesion affected sensitivity to satiety‐specific outcome devaluation or non‐reinforcement (i.e. extinction), and neither had effects when placed after animals were trained on a progressive ratio response schedule. Lesions of the ventral hippocampus, which projects to the mOFC, resulted in similar response patterns, while lateral OFC and dorsal hippocampus lesions resulted in response acquisition, though not inhibition, deficits in an instrumental reversal. Our findings thus selectively implicate the rodent mOFC in braking reinforced goal‐directed action when reinforcement requires the acquisition of novel response contingencies.
Effect of Marine-Derived Ice-Binding Proteins on the Cryopreservation of Marine Microalgae

Ice-binding protein (IBPs) protect cells from cryo-injury during cryopreservation by inhibiting ice recrystallization (IR), which is a main cause of cell death. In the present study, we employed two IBPs, one, designated LeIBP from Arctic yeast, and the other, designated FfIBP from Antarctic sea ice bacterium, in the cryopreservation of three economically valuable marine microalgae, Isochrysis galbana, Pavlova viridis, and Chlamydomonas coccoides. Both of the IBPs showed IR inhibition in f/2 medium containing 10% DMSO, indicating that they retain their function in freezing media. Microalgal cells were frozen in 10% DMSO with or without IBP. Post-thaw viability exhibited that the supplementation of IBPs increased the viability of all cryopreserved cells. LeIBP was effective in P. viridis and C. coccoides, while FfIBP was in I. galbana. The cryopreservative effect was more drastic with P. viridis when 0.05 mg/mL LeIBP was used. These results clearly demonstrate that IBPs could improve the viability of cryopreserved microalgal cells.
‘You have to let go to hold on’: a rock climber's reflective process through resonance

Resonance is a process that empowers people to design their life in a way that allows them to feel the way they want to feel. In this holistic process, individuals identify how they want to feel, prepare to experience these feelings, recognize obstacles that prevent them, and reconnect with desired feelings when they are disengaged from the process. Reflection, a conscious and intentional exploration process leading to a better understanding of complex ideas, is an inherent constituent of resonance. It allows individuals to enhance their self‐awareness, which they use to design their resonance process and life. This article illustrates an athlete's reflective process and how it was fuelled by the facilitator of the resonance‐based intervention in which he took part. It also outlines many realizations and the personal progress that resulted from the athlete's experience with resonance.
The short- and long-term effects of secondary schools upon students’ academic success and development

This paper presents the results of a study investigating the short- and long-term effects of secondary schools upon student academic success and development. A questionnaire was administered to a randomly selected sample of 15% of Cypriot students who graduated in June 2004 and June 2005 from secondary schools. A good response rate (i.e., 66%) was obtained. For each criterion of measuring school effects, separate multilevel analysis was conducted. The results provide evidence for statistically significant school effects on students’ success at the university entrance exams and on their academic success and development. Suggestions for further research are provided, and policy implications are finally drawn.
Strobovideolaryngoscopy: Results and Clinical Value

Strobovideolaryngoscopy is a valuable addition to the diagnostic armamentarium because it allows the otolaryngologist to perform a detailed physical examination of the vibratory margin of the vocal fold. From 1985 through 1989, we performed 1,876 strobovideolaryngoscopy procedures, the majority on professional voice users. Previously, we reported findings on our first 486 strobovideolaryngoscopy procedures. Stroboscopic information influenced diagnosis or treatment in approximately one third. The present study was undertaken to determine whether additional experience had altered the clinical usefulness of the procedure. Diagnoses were noted before and after stroboscopy prospectively for 377 strobovideolaryngoscopy procedures performed during the calendar year 1989. In 53% of the procedures, strobovideolaryngoscopy resulted in no change in diagnosis. In 29%, preprocedure impressions were confirmed and additional diagnoses were made. In 18%, preprocedure diagnoses were found to be incorrect. The procedure has proven very helpful in caring for voice patients, modifying diagnoses in 47%, and confirming uncertain diagnoses in many of the other patients studied.
Preferential release of high amounts of interleukin-8 by myeloid blasts showing monocytic differentiation.

BACKGROUND In myeloid blasts, the expression and release of the multifunctional chemokine IL-8 could be expected to be differentiation-associated. METHODS We investigated the profile of interleukin-8 (IL-8) expression and release by leukemic cells obtained at diagnosis from 42 untreated adult patients with acute myeloid leukemia of various FAB subtypes (2 M0, 7 M1, 6 M2, 6 M3, 10 M4 and 11 M5). IL-8 transcripts were evaluated by Northern blot and densitometric analysis. IL-8 release by myeloid blasts was evaluated by a specific ELISA either in sera at diagnosis or in supernatants (SN) obtained from cultured leukemic cells. RESULTS In basal conditions, Northern blot analysis revealed detectable IL-8 transcripts in 15/29 cases, eleven of which were classified as M4-M5 and 4 as FAB M0-M3. Densitometric analysis of IL-8 transcript bands showed higher expression in M4-M5 than in M0-M3 cases (mean values +/- SD: 16.5 +/- 21 and 0.77 +/- 1.36 densitometric units, respectively; p = 0.012). Higher IL-8 serum levels were observed in leukemic patients as opposed to normal controls (mean values +/- SD: 0.53 +/- 0.75 vs 0.003 +/- 0.014 ng/mL, respectively; p = 0.006). Furthermore, a trend (though not of statistical significance) towards higher IL-8 serum values was observed in M4-M5 as opposed to M0-M3 subtypes. After 24 hours of culture, the majority of myeloid blasts (95%) spontaneously released detectable amounts of IL-8 into SN. However, M4-M5 released substantially higher amounts of IL-8 than M0-M3 blasts (mean +/- SD: 68 +/- 46 and 8.5 +/- 12 ng/mL, respectively; p < 0.001). This difference between M0-M3 and M4-M5 blasts was already observed after 6 hours of culture and increased over 72 hours. CONCLUSIONS Our findings confirm and further support the preferential release of high levels of IL-8 by myeloid blasts showing monocytic differentiation.
Coping with Children with ADHD: Coping Styles of Mothers with Children with ADHD or Challenging Behaviours

Parents of children with Attention Deficit Hyperactivity Disorder (ADHD) can experience significant levels of stress in their parenting roles, however, little is known about the specific coping strategies used by these parents. This pilot study Investigated the coping strategies used by mothers of children with ADHD. A 34 item questionnaire was developed to identify maternal coping strategies. A cohort of 38 mothers of children with ADHD and a control group of 30 mothers of children without ADHD or any other disability/illness completed the questionnaire. Factor analysis of responses produced three factors: Aggressive/Confrontive Coping, Rational Coping, and Indirect Coping. These factors are similar to coping dimensions proposed by Folkman and Lazarus. Comparisons between the two groups of mothers revealed that mothers of children with ADHD used significantly more Indirect Coping.
Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study

Background It has been suggested that working memory deficits is a core feature of symptomatology of schizophrenia, which can be detected in patients and their unaffected relatives. The impairment of working memory has been found related to the abnormal activity of human brain regions in many functional magnetic resonance imaging (fMRI) studies. This study investigated how brain region activation was altered in schizophrenia and how it was inherited independently from performance deficits. Method The authors used fMRI method during N-back task to assess working memory related cortical activation in four groups (N = 20 in each group, matching task performance, age, gender and education): schizophrenic patients, their unaffected biological parents, young healthy controls for the patients and older healthy controls for their parents. Results Compared to healthy controls, patients showed an exaggerated response in the right dorsolateral prefrontal cortex (brodmann area [BA] 46) and bilateral ventrolateral prefrontal cortex, and had reduced activation in bilateral dorsolateral prefrontal cortex (BA 9). In the conjunction analysis, the effect of genetic risk (parents versus older control) shared significantly overlapped activation with effect of disease (patients versus young control) in the right middle frontal gyrus (BA 46) and left inferior parietal gyrus (BA 40). Conclusions Physiological inefficiency of dorsal prefrontal cortex and compensation involvement of ventral prefrontal cortex in working memory function may one physiological characteristics of schizophrenia. And relatively inefficient activation in dorsolateral prefrontal cortex probably can be a promising intermediate phenotype for schizophrenia.
Effects of Damaging the Endocardial Surface on the Mechanical Performance of Isolated Cardiac Muscle

The mechanical properties of mammalian ventricular cardiac muscle have been studied in the presence and in the absence of an intact endocardial surface. Isotonic and isometric twitch contractions were obtained from papillary muscles of the right ventricle of cat at 29° and 37° C, at different extracellular calcium concentrations ([Ca2+]o), and at different initial muscle lengths. The endocardial surface was damaged by gentle abrasion of the muscle surface with a plastic blade or by brief immersion for 1 second with 1 % Triton X-100. Although there was no evidence of damage to myocardial cells, damaging the endocardial surface resulted in an immediate and irreversible abbreviation of the twitch contractions with, except at the highest [Ca2+]. , a decrease in peak isometric twitch tension. These changes induced 1) an asymmetrical shift of the tension-[Ca2+] relation towards increasing [Ca2+] but with no effect at the highest [Ca2+]o, and 2) a rightward and downward shift of the length-tension relation. Both shifts were significantly more pronounced at 37° C than at 29° C; they were not accompanied by significant changes in Vmax. The asymmetrical shift of the tension-[Ca2+]o relation suggests that the endocardium-mediated chain of events may be mediated by changes in the sensitivity of the contractile proteins to Ca2+. This hypothesis is also supported by the similar pattern of changes (i.e., modulation of the onset of early tension decline) induced by decreasing length at each [Ca2+]. and by the removal of a functional endocardium. Accordingly, the endocardium may help to control the performance of the heart by modulating peak contractile performance and relaxation of the underlying myocardium.
A systematic review of the evidence on the effect of the built and physical environment on mental health

This paper assesses the strength of the evidence on the impact of the physical environment on mental health and well‐being. Using a systematic review methodology, quantitative and qualitative evaluative studies of the effect of the physical environment on child and adult mental health published in English between January 1990 and September 2005 were sought from citation databases. The physical environment was defined in terms of built or natural elements of residential or neighbourhood environments; mental health was defined in terms of psychological symptoms and diagnoses. A total of 99 papers were identified. The strength of the evidence varied and was strongest for the effects of urban birth (on risk of schizophrenia), rural residence (on risk of suicide for males), neighbourhood violence, housing and neighbourhood regeneration, and neighbourhood disorder. The strength of the evidence for an effect of poor housing on mental health was weaker. There was a lack of robust research, and of longitudinal research in many areas, and some aspects of the environment have been very little studied to date. The lack of evidence of environmental effects in some domains does not necessarily mean that there are no effects: rather, that they have not yet been studied or studied meaningfully.
The Use of Temporary Skilled Migration in Australian Organisations

Purpose – The spread of economic global integration in the last 50 years has resulted in the recent emergence of global labour markets. Ageing populations and skill shortages have placed significant pressure upon Australia's economic sustainability and survival in a global economy. The global race for talent has seen the emergence of skilled migration as a key element in Australia's strategy to address major human capital trends and issues and to source pools of talent considered highly skilled or in demand. This paper seeks to address these issues.Design/methodology/approach – This paper draws together research on skilled migration in the Australian context and the factors that explain use of Australia's 457 visa scheme by organisations for attracting and recruiting talent. Data from a survey of members of the Australian Human Resources Institute (n=1,045) is analysed using logistic regression.Findings – The results show that larger, goods producing, organisations with skills shortages are more likely to.