Miracle-dz/UniFAR-FTUs huggingface dataset:
Segmental Diffusion Properties of the Corticospinal Tract and Motor Outcome in Hemiparetic Children With Perinatal Stroke

Perinatal stroke injures developing motor systems, resulting in hemiparetic cerebral palsy. Diffusion tensor imaging can explore structural connectivity. We used diffusion tensor imaging to assess corticospinal tract diffusion in hemiparetic children with perinatal stroke. Twenty-eight children (6-18 years) with unilateral stroke underwent diffusion tensor imaging. Four corticospinal tract assessments included full tract, partial tract, minitract and region of interest. Diffusion characteristics (fractional anisotropy, mean, axial, and radial diffusivity) were calculated. Ratios (lesioned/nonlesioned) were compared across segments and to validated long-term motor outcomes (Pediatric Stroke Outcome Measure, Assisting Hand Assessment, Melbourne Assessment). Fractional anisotropy and radial diffusivity ratios decreased as tract size decreased, while mean diffusivity showed consistent symmetry. Poor motor outcomes were associated with lower fractional anisotropy in all segments and radial diffusivity correlated with both Assisting Hand Assessment and Melbourne Assessment. Diffusion imaging of segmented corticospinal tracts is feasible in hemiparetic children with perinatal stroke. Correlations with disability support clinical relevance and utility in model development for personalized rehabilitation.
Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma

Background Understanding of immune mechanisms underpinning asthma has emerged from studies in adults. It is increasingly recognised, both immunologically and in the development of novel therapies, that adult responses cannot be used accurately to predict those of children. Methods Using a well-defined paediatric cohort of severe therapy-resistant asthma (STRA) patients, we investigated cytokine profiles in the airway by analysis of bronchoalveolar lavage fluid. The in vitro capacity of peripheral blood mononuclear cells (PBMCs) for cytokine production was also assessed following polyclonal T cell activation in culture, in the absence or presence of dexamethasone and 1α,25-dihydroxyvitamin D3. Results Children with both moderate and STRA had significantly diminished levels of anti-inflammatory interleukin (IL)-10 in airway lavage samples when compared with non-asthmatic controls (p<0.001). Their PBMCs also demonstrated significantly impaired capacity to secrete IL-10 in culture (p<0.001). Dexamethasone regulated the balance between PBMC IL-10 and IL-13 production, increasing IL-10 secretion (p<0.001) and decreasing IL-13 (p<0.001) but unexpectedly enhanced IL-17A production in all groups—most strikingly in the STRA cohort (p<0.001). The inclusion of the active form of vitamin D, 1α,25-dihydroxyvitamin D3, in culture enhanced dexamethasone-induced IL-10 (p<0.05) without marked effects on IL-13 or IL-17A production. Furthermore, systemic vitamin D status directly correlated with airway IL-10 (r=0.6, p<0.01). Conclusions These findings demonstrate reduced peripheral and local IL-10 synthesis in paediatric asthma, and support therapeutic augmentation of low circulating vitamin D in severe, difficult-to-treat asthma, in order to correct impaired IL-10 levels. Conversely, steroids enhanced IL-17A levels, and therefore any steroid-sparing properties of vitamin D may have additional benefit in STRA.
The theory and practice of signal strength-based location estimation

Location estimation enables many innovative applications and is an exciting area of research. With the growing use of wireless technology in enterprise networks, it is an interesting technical challenge to develop techniques for indoor location estimation that leverage the deployed wireless infrastructure. Elegant, cost-effective techniques would present a compelling business proposition. In this paper, we summarize various approaches researchers have studied for the problem of indoor location estimation, concentrating on signal-strength based techniques directed towards 802.11 wireless networks. We also summarize an interesting insight into the best possible accuracy achievable by any technique due to limits imposed by the physical behavior of the radio signal. We identify that the issues driving research work in this area will not only be location accuracy, but other factors like deployment ease, management simplicity, adaptability, and cost of ownership and maintenance. We conclude with some open research problems in this area
Mirror, mirror on the wall: identifying processes of classroom assessment

In a recent issue of Language Testing, Rea-Dickins and Gardner (2000) reported on their work in classroom-based assessment, and provided examples of different ways in which information from learner assessments was used by teachers working with learners for whom English is an additional/second language (EAL). The research reported here is also concerned with classroom assessment in an EAL school context. As in the previous article, it is presented from the perspective that issues of classroom assessment and, in particular, formative assessment require further detailed analysis. Using data from teacher interviews, classroom observations, video and audio recordings of learners, and lesson transcripts, the starting point for this investigation is the concept of the assessment cycle. Taking a grounded approach, it traces different stages in the teacher assessment process and presents a working model for the analysis of teacher decision making in relation to assessment practices. At the same time, it identifies classroom assessment as a multifaceted phenomenon with distinct identities linked to learning, teaching and bureaucratic functions.
Examining the Structures That Impact English Language Learners’ Agency in Urban High Schools: Resources and Roadblocks in the Classroom

This qualitative study focused on the classroom experiences of 14 English Language Learners (ELL) students in urban high schools. The authors argue that specific structures within classrooms and schools affect ELL students’ agency, or their ability to access and appropriate resources to meet their learning and social needs. Using a narrative inquiry methodological framework, the authors found that these structures included resources, such as space, and time, and a schema of caring, which were created by teachers’ practices. They also included roadblocks, such as poor instructional practices, a lack of empathy of students’ experiences, and diminished access to the curriculum.
Priming Bush (vs. Obama) increases liking of American brands: The role of intersubjectively important values

Past research has shown that exposure to cultural symbols can influence personal preferences. The present research extends this finding by showing that cultural symbols acquire their cultural significance in part through their associations with intersubjectively important values—values that are perceived to be prevalent in the culture. In addition, cultural symbols can influence personal preferences through the activation of perceived normative preferences. In Study 1, perceived liking of Bush among Americans was linked to the perceived popularity of intersubjectively important values in the USA. In Study 2, both priming Bush and personal endorsement of intersubjectively important values increased Americans' liking of iconic brands (brands that symbolize American culture). Furthermore, perceived normative preferences for iconic brands fully mediated this effect.
Integrating Scenario–Based and Component Reading Skill Measures to Understand the Reading Behavior of Struggling Readers

In recent years, researchers, educators, and policy makers have called for a new generation of reading comprehension assessments (e.g., Partnership for 21st Century Skills, 2008). Advocates of this movement argue for a deeper type of reading assessment, one that captures students’ ability to not only understand single texts in isolation but also to engage in purposeful, multisource integration of sources. While this shift in how we define and measure reading comprehension is laudable, assessments must also measure the fundamental reading skills that may impede higher–level comprehension processes. This article presents data from two assessments that were designed to work in tandem to provide a more complete picture of reading comprehension. Middle school students were given a component skills battery which measured core reading skills such as word recognition, decoding, vocabulary, and morphology, as well a second assessment designed to measure reading comprehension. Reading comprehension was measured using a scenario–based assessment approach, which required students to read a range of sources to fulfill a particular reading goal. The results indicate that students, including struggling readers, were able to read, understand, and problem solve in complex learning environments, but students’ ability to do so was often tempered by their basic reading skills. We argue that including a measure of component skills alongside a measure of higher–level comprehension is beneficial in interpreting student performance. Accordingly, we present the results on the scenario–based measure as a function of reading component skills and argue for the value of using this approach for struggling readers.
The relationship between values and leadership styles of nonprofit leaders

The U.S. nonprofit sector is in need of reforms to restore public trust after several highly publicized scandals resulting from mismanagement and leadership failures undermined the reputation of the sector. Selecting transformational leaders who can bring positive, values-based change to the nonprofit industry represents a significant challenge and an opportunity. Understanding the relationship between values and leadership styles of nonprofit leaders can assure nonprofit boards that transformational leaders have strong values systems and can also assist nonprofit boards in the leadership assessment and selection process. The goal of this quantitative, correlational research study was to measure the relationship between the leadership styles (transformational, transactional, and laissez-faire) and values (personal, social, morality-based, and competency-based) of nonprofit leaders in Essex County, Massachusetts. One hundred forty-three survey responses were collected from a population of 988 nonprofit leaders. The data were subjected to statistical analysis through descriptive statistics and regression analysis to determine the relationship between leadership style indices and values scores. The results suggest a moderate, yet significant positive correlation between transformational leadership style indices and values scores for all four types of values. A significant correlation exists between transactional leadership style indices and values scores, with the exception of personal and morality-based values. Additionally, the results suggest a low, yet significant negative correlation between laissez-faire leadership style indices and all four types of values. A low percentage of the proportion of the total variation in leadership style indices can be explained by the variation in the values scores of the respondents.
Baerveldt shunt surgery versus combined Baerveldt shunt and phacoemulsification: a prospective comparative study

Aim To examine the efficacy and safety of Baerveldt tube (BT) implantation compared with combined phacoemulsification and Baerveldt tube (PBT) implantation in patients with refractory glaucoma. Methods Seventy-six eyes of 76 patients were enrolled, 38 pseudophakic eyes underwent BT implantation alone and 38 phakic eyes underwent the BT implantation combined with phacoemulsification. Groups were matched for preoperative intraocular pressure (IOP) and number of glaucoma medications. Preoperative and postoperative measures recorded included patient demographics, visual acuity (VA), IOP, number of antiglaucoma medications and all complications. Patients were followed up for a minimum of 36 months. Failure was defined as: inadequate IOP control (IOP≤5 mm Hg/>21 mm Hg/<20% reduction from baseline, reoperation for glaucoma, loss of light perception vision, or removal of the implant). Results There was a significant difference in failure rates between groups at 36 months (PBT 37% vs BT 15%, P=0.02). There was no significant difference for PBT versus BT in preoperative baseline ocular characteristics. At 36 months: median IOP=14 mm Hg vs 12 mm Hg, P=0.04; mean number of antiglaucomatous medications=1.7 vs 1.3, P=0.61; median VA=0.8 vs 0.7, P=0.44. Postoperative complication rates were similar in both groups (n=5 vs 5; 13% vs 13%). Conclusions Failure rates were significantly greater in the PBT group at 3 years. Median IOP was also significantly higher in the PBT group. These results suggest that combining phacoemulsification with aqueous shunt surgery may have a negative effect on long-term shunt bleb survival.
Macrosteatotic and nonmacrosteatotic grafts respond differently to intermittent hepatic inflow occlusion: Comparison of recipient survival

Intermittent hepatic inflow occlusion (IHIO) during liver graft procurement is known to confer protection against graft ischemia/reperfusion injury and thus may benefit the recipient's outcome. We evaluated whether the protective effect of IHIO differs with the presence of macrosteatosis (MaS) and with an increase or decrease in the cumulative occlusion time. The subgroup of 188 recipients who received grafts with MaS was divided into 3 groups according to the number of total IHIO rounds during graft procurement: no IHIO, n = 70; 1 to 2 rounds of IHIO, n = 50; and ≥3 rounds of IHIO, n = 68. Likewise, the subgroup of 200 recipients who received grafts without MaS was divided into 3 groups: no IHIO, n = 108; 1 to 2 rounds of IHIO, n = 40; and ≥3 rounds of IHIO, n = 52. The Cox model was applied to evaluate the association between the number of total IHIO rounds and recipient survival separately in the subgroup of MaS recipients and the subgroup of non‐MaS recipients. Analyzed covariables included the etiology, Milan criteria, transfusion, immunosuppression, and others. In the subgroup of MaS recipients, 1 to 2 rounds of IHIO were favorably associated with recipient survival [hazard ratio (HR), 0.29; 95% confidence interval (CI), 0.10‐0.80; P = 0.03 after Bonferroni correction], whereas ≥3 rounds of IHIO were not associated with recipient survival (HR, 0.56; 95% CI, 0.25‐1.23). In the subgroup of non‐MaS recipients, neither 1 to 2 rounds of IHIO (HR, 0.69; 95% CI, 0.30‐1.61) nor ≥3 rounds of IHIO (HR, 0.91; 95% CI, 0.42‐1.96) were associated with recipient survival. In conclusion, 1 to 2 rounds of IHIO may be used for the procurement of MaS grafts with potential benefit for recipient survival, whereas IHIO has a limited impact on recipient survival regardless of the cumulative occlusion time when it is used for non‐MaS grafts. Liver Transpl 21:644–651, 2015. © 2015 AASLD.
Satisfiability Thresholds for k-CNF Formula with Bounded Variable Intersections

We determine the thresholds for the number of variables, number of clauses, number of clause intersection pairs and the maximum clause degree of a k-CNF formula that guarantees satisfiability under the assumption that every two clauses share at most $\alpha$ variables. More formally, we call these formulas $\alpha$-intersecting and define, for example, a threshold $\mu_i(k,\alpha)$ for the number of clause intersection pairs $i$, such that every $\alpha$-intersecting k-CNF formula in which at most $\mu_i(k,\alpha)$ pairs of clauses share a variable is satisfiable and there exists an unsatisfiable $\alpha$-intersecting k-CNF formula with $\mu_m(k,\alpha)$ such intersections. We provide a lower bound for these thresholds based on the Lovasz Local Lemma and a nearly matching upper bound by constructing an unsatisfiable k-CNF to show that $\mu_i(k,\alpha) = \tilde{\Theta}(2^{k(2+1/\alpha)})$. Similar thresholds are determined for the number of variables ($\mu_n = \tilde{\Theta}(2^{k/\alpha})$) and the number of clauses ($\mu_m = \tilde{\Theta}(2^{k(1+\frac{1}{\alpha})})$) (see [Scheder08] for an earlier but independent report on this threshold). Our upper bound construction gives a family of unsatisfiable formula that achieve all four thresholds simultaneously.
‘Just do a little more’: examining expertise in high performance sport from a sociocultural learning perspective

Research suggests that extensive training is necessary for the development of sporting expertise. Research also suggests that extensive training can lead to overuse injuries. The aims of this paper are to: (1) expand the concept of expertise in high performance sport, and (2) contribute to the discussion of how high performance athletes move towards expert performance in sustainable ways. To achieve these aims, data from retrospective interviews with four Olympians from four different sports are presented. As a way of extending traditional approaches, a pedagogical framework focusing on dispositional learning is employed to examine athletic development. The notion of threshold concepts is used as a specific analytic tool for thinking about how athletes come to make sense of their sporting environments. Interpretations of the data provide insights into the nature of thresholds in high performance sport, factors that facilitate threshold crossing, and factors that may prevent athletes from making advances, all of which have implications for practitioners interested in developing expertise.
Coming of (Old) Age in the Digital Age: ICT Usage and Non-Usage among Older Adults

Most developed countries are in the midst of two significant societal trends: the first is an aging population; the second is the uptake of Information and Communication Technologies (ICT) by large segments of society. But research shows a strong association between age and the so-called digital divide: older adults are less likely to use ICT when compared to other age groups. If we consider the social affordances of the Internet and the online migration of several public and private services, the lack of access or of digital literacy might be increasing age-related inequality. Consequently, we studied adoption, usage, and non-usage of ICT (mobile phones, computers, and the Internet) by Portuguese older adults. For that, we surveyed a random stratified sample of 500 individuals over 64 years of age living in Lisbon. Of this sample, 77% owned a mobile phone, 13% used computers, and 10% used the Internet. The main reasons for non-usage were functional and attitudinal, rather than physical or associated with age. But usage of mobile phones and computers was predicted by age and education, whereas the usage of the Internet was only predicted by education. We followed up the survey with 10 qualitative interviews, using a mixed methods strategy. The qualitative data showed a general positive perception of ICT as well as the importance of family and intergenerational relationships for technology adoption and use.
Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Methods to assess visceral hypersensitivity in irritable bowel syndrome.

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, characterized by recurrent abdominal pain or discomfort in combination with disturbed bowel habits in the absence of identifiable organic cause. Visceral hypersensitivity has emerged as a key hypothesis in explaining the painful symptoms in IBS and has been proposed as a "biological hallmark" for the condition. Current techniques of assessing visceral perception include the computerized barostat using rectal distensions, registering responses induced by sensory stimuli including the flexor reflex and cerebral evoked potentials, as well as brain imaging modalities such as functional magnetic resonance imaging and positron emission tomography. These methods have provided further insight into alterations in pain processing in IBS, although the most optimal method and condition remain to be established. In an attempt to give an overview of these methods, a literature search in the electronic databases PubMed and MEDLINE was executed using the search terms "assessment of visceral pain/visceral nociception/visceral hypersensitivity" and "irritable bowel syndrome. " Both original articles and review articles were considered for data extraction. This review aims to discuss currently used modalities in assessing visceral perception, along with advantages and limitations, and aims also to define future directions for methodological aspects in visceral pain research. Although novel paradigms such as brain imaging and neurophysiological recordings have been introduced in the study of visceral pain, confirmative studies are warranted to establish their robustness and clinical relevance. Therefore, subjective verbal reporting following rectal distension currently remains the best-validated technique in assessing visceral perception in IBS.
LPS-Induced Systemic Inflammation Does Not Alter Atherosclerotic Plaque Area or Inflammation in APOE3*LEIDEN Mice in the Early Phase Up to 15 Days

Background and Aims: Observational studies show a peak incidence in cardiovascular events during and early after clinical conditions associated with substantial systemic inflammation, such as pneumonia. The acuteness of this increased risk suggests rapid plaque destabilization and associated intraplaque inflammation. We evaluated whether lipopolysaccharides (LPS)-evoked acute systemic inflammation would induce such detrimental vascular changes in murine aortas with manifest atherosclerotic lesions. Methods and Results: ApoE3*Leiden mice were fed a high cholesterol diet for 20 weeks to establish atherosclerosis. Thereafter, mice received a single intraperitoneal injection with LPS to induce systemic inflammation, or saline for control. Mice were sacrificed 2 or 15 days post-LPS injection (n = 17) or post-saline injection (n = 13). Serum amyloid A, a sensitive marker of systemic inflammation, increased 250-fold in LPS-treated mice. Aortic root plaques were assessed for total plaque area, plaque severity, and inflammatory cell content. No significant differences in total surface area of atherosclerotic plaque were found between control and LPS groups sacrificed after 2 days (resp. 0.409 ± 0.228 × 105 &mgr;m2 vs. 0.285 ± 0.169 × 105 &mgr;m2) (P = 0.31), and 15 days (resp. 0.950 ± 0.938 × 105 &mgr;m2 vs. 0.612 ± 0.413 × 105 &mgr;m2) (P = 0.80). Furthermore, plaque type and number of lesions were unaltered and intraplaque density of macrophages and lymphocytes were comparable in both the groups. Conclusions: Intraperitoneal LPS injection in ApoE3*Leiden mice triggers a profound systemic inflammatory response, but does not increase atherosclerotic plaque area or inflammatory cell density. This model of LPS-induced inflammation in atherosclerosis-prone mice argues against intraplaque alterations as an explanation for acute inflammation-induced cardiovascular event risk.