Miracle-dz/UniFAR-FTUs huggingface dataset:
Conjunctive Queries for EL with Composition of Roles

EL is a rather expressive description logic (DL) that still adm its polynomial time inferencing for many reasoning tasks. Conj unctive queries are an important means for expressive querying of DL knowledge b ases. We address the problem of computing conjunctive query entailmen t for EL knowledge bases. As it turns out, querying unrestricted EL is actually undecidable, but we identify restrictions under which query answering be comes decidable and even tractable. We give precise characterisations of schem a, query, and combined complexity. To the best of our knowledge, the presented algo rithm is the first to answer conjunctive queries in a DL that admits complex role i nclusion axioms.
River response to large‐dam removal in a Mediterranean hydroclimatic setting: Carmel River, California, USA

Dam removal provides a valuable opportunity to measure the fluvial response to changes in both sediment supply and the processes that shape channel morphology. We present the first study of river response to the removal of a large (32‐m‐high) dam in a Mediterranean hydroclimatic setting, on the Carmel River, coastal California, USA. This before‐after/control‐impact study measured changes in channel topography, grain size, and salmonid spawning habitat throughout dam removal and subsequent major floods. During dam removal, the river course was re‐routed in order to leave most of the impounded sediment sequestered in the former reservoir and thus prevent major channel and floodplain aggradation downstream. However, a substantial sediment pulse occurred in response to base‐level fall, knickpoint migration, and channel avulsion through sediment in the former reservoir above the newly re‐routed channel. The sediment pulse advanced ~3.5 km in the first wet season after dam removal, resulting in decreased riverbed grain size downstream of the dam site. In the second wet season after dam removal, high flows (including a 30‐year flood and two 10‐year floods) transported sediment > 30 km downstream, filling pools and reducing cross‐channel relief. Deposition of gravel in the second wet season after dam removal enhanced salmonid spawning habitat downstream of the dam site. We infer that in dam removals where most reservoir sediment remains impounded and where high flows follow soon after dam removal, flow sequencing becomes a more important driver of geomorphic and fish‐habitat change than the dam removal alone. © 2018 John Wiley & Sons, Ltd.
An index of coastal thermal effects of El Niño Southern Oscillation on the Peruvian Upwelling Ecosystem

The Peruvian Upwelling Ecosystem (PUE) is one of the most productive ecosystem in the world in terms of productivity and fish catches, partly because its geographical location is affected by remote physical processes, such as the interannual climate variability of the Equatorial Pacific Ocean (EPO), whose dominant signal is El Niño Southern Oscillation (ENSO). In order to assess the thermal effects of ENSO off Peru, a Peruvian Coastal Thermal Index (PCTI) was developed representing 87.7% of the total variation of the Sea Surface Temperature (SST) anomalies of the PUE. Between 1982 and 2014, the PCTI detected 12 warm periods and 16 cold periods in the PUE. PCTI had a linear trend component, a low frequency component and a noise component, with 1.5%, 94.5% and 4% contributions to the total variance, respectively. Wavelet analysis of PCTI showed significant peaks of variability between the years 1996 and 1999 between periods of 0.4 and 6 years. A regime shift in variance of PCTI was detected in 1999, with a lower variance between 1999 and 2014 than between 1982 and 1998, which agreed with the start of a cold phase of the Pacific Decadal Oscillation. The decrease of variance of the PCTI could be linked to an increase of the local winds associated with a higher intensity of the average state of South Pacific Anticyclone. This atmospheric change might have strengthened the coastal upwelling and counteracted the intensity of warm periods in the PUE. Finally, the comparison of different indexes allowed to detect four periods where neutral conditions occurred in the EPO while warm periods occurred in the PUE (1993, 2008, 2012 and 2014); and 1 period where a warm episode occurred in the EPO (2004–2005) while a neutral condition occurred in the PUE.
> Replace This Line with Your Paper Identification Number (double-click Here to Edit) < Single-chip Wavelength Conversion Using a Photocurrent-driven Eam Integrated with a Widely Tunable Sampled-grating Dbr Laser

— Tunable photocurrent-driven wavelength converters using widely tunable sampled grating distributed Bragg reflector lasers, electroabsorption modulators, semiconductor optical amplifiers, and an optically pre-amplified receiver have been fabricated and tested. Dynamic wavelength conversion has been achieved over 40 nm with optical bandwidths up to 10 GHz.
Snowflake Melting Simulation Using Smoothed Particle Hydrodynamics

Motivated by the need to understand the microphysics and improve the remote sensing of the melting layer of precipitation, we have developed a numerical 3‐D model for the melting of single snowflakes. The model uses the smoothed particle hydrodynamics method and is forced by surface tension that controls the flow of meltwater on the ice surface. Heat transfer from the environment to the snowflake is simulated with a Monte Carlo scheme. In model experiments with snowflakes of various sizes and densities, we observed that the meltwater tends to initially gather in concave regions of the snowflake surface. These liquid water regions merge as they grow, and as meltwater is added, they form a shell of liquid around an ice core. This eventually develops into a water drop. The observed features during melting are consistent with experimental findings from earlier research, which suggests that the model is adequate for exploring the physics of snowflake melting. The principal remaining uncertainties arise from the omission of aerodynamic forces from the model. The results suggest that the degree of riming has a significant influence on the melting process: During initial melting, liquid water is apparent on the surface of unrimed or lightly rimed particles, while rime provides a porous structure that can absorb a relatively large amount of meltwater. Riming also strengthens the connections between different parts of the snowflake, making rimed snowflakes less prone to breakup during melting, while unrimed ones break up rather easily.
Incorporating user inputs in motion planning for a smart wheelchair

We describe the development and assessment of a computer controlled wheelchair equipped with a suite of sensors and a novel interface, called the SMARTCHAIR. The main focus of this paper is a shared control framework which allows the human operator to interact with the chair while it is performing an autonomous task. At the highest level, the autonomous system is able to plan paths using high level deliberative navigation behaviors depending on destinations or waypoints commanded by the user. The user is able to locally modify or override previously commanded autonomous behaviors or plans. This is possible because of our hierarchical control strategy that combines three independent sources of control inputs: deliberative plans obtained from maps and user commands, reactive behaviors generated by stimuli from the environment, and user-initiated commands that might arise during the execution of a plan or behavior. The framework we describe ensures the user's safety while allowing the user to be in complete control of a potentially autonomous system.
SPACER: server for predicting allosteric communication and effects of regulation

The SPACER server provides an interactive framework for exploring allosteric communication in proteins with different sizes, degrees of oligomerization and function. SPACER uses recently developed theoretical concepts based on the thermodynamic view of allostery. It proposes easily tractable and meaningful measures that allow users to analyze the effect of ligand binding on the intrinsic protein dynamics. The server shows potential allosteric sites and allows users to explore communication between the regulatory and functional sites. It is possible to explore, for instance, potential effector binding sites in a given structure as targets for allosteric drugs. As input, the server only requires a single structure. The server is freely available at http://allostery.bii. a-star.edu. sg/.
Serotonin modulates photic responses in the hamster suprachiasmatic nuclei

The aim of the present study was to examine the effects of serotonin agonists on three elements of the photic response in the hamster suprachiasmatic nuclei (SCN). Both serotonin and the selective 5-HT1A agonist 8-OH-DPAT inhibited field potentials recorded in the SCN in response to optic nerve stimulation in the hypothalamic slice preparation. The effects of both drugs were dose related over a concentration range of 1–50 microM, and, in both cases, a maximal inhibition of approximately 60% was achieved at a concentration of 25– 50 microM. Systemic administration of 8-OH-DPAT inhibited light- stimulated Fos expression in the SCN. A regionally selective pattern of inhibition was observed, with decreases restricted predominately to the ventral and dorsal borders of the SCN. Finally, systemic administration of 8-OH-DPAT was found to dose-dependently attenuate light-induced phase shifts of the free-running activity rhythm. The effects of 8-OH- DPAT on light-induced phase advances were dose dependent. Injection of 8-OH-DPAT at a dose of 0.5 mg/kg caused 57% inhibition of light-induced phase advances, while a dose of 5 mg/kg inhibited the phase advance by 82%. Injection of 0.05 mg/kg 8-OH-DPAT did not significantly inhibit light-induced phase advances. Injection of 5 mg/kg 8-OH-DPAT alone did not significantly alter the phase of the activity rhythm. Similarly, injection of 5 mg/kg 8-OH-DPAT 30 min prior to light stimulation at CT14 completely inhibited light-induced phase delays, while this dose of the drug did not alter the phase of the activity rhythm when administered alone. (ABSTRACT TRUNCATED AT 250 WORDS)
Heterogeneous Beliefs, Wealth Distribution, and Asset Markets with Risk of Default †

We study asset markets and wealth dynamics in the economy with heterogeneous beliefs and risk of default. Agents can trade a full set of Arrow securities but are allowed to default on their delivery promises. Financial markets rationally subject agents to the endogenous "no-default" borrowing limits. Because of the rich menu of financial assets traded in the market speculation opportunities are plentiful. Financial wealth is volatile and the endogenous borrowing limits are always active. Variance of the asset returns is amplified. The asset trading volume is substantial and volatile.
A prospective evaluation of the effect of salpingectomy on endometrial receptivity in cases of women with communicating hydrosalpinges.

BACKGROUND We aimed to assess whether salpingectomy in women with communicating hydrosalpinges influenced endometrial receptivity. METHODS The inclusion criteria were: women with communicating hydrosalpinges, absence of other confounding infertility factors and aged <40 years. Patients were scheduled for laparoscopy during the putative window of implantation (cycle days 19-21). In patients in whom salpingectomy was decided upon due to the severity of tubal disease (n = 10), an intra-operative endometrial biopsy was performed. Post-treatment endometrial sampling was done between day 19-21 of the fourth consecutive cycle. Pre-treatment and post-treatment samples were assessed by both conventional histologic criteria and alpha(v)beta3 integrin immunostaining, where histological score (HSCORE) was used for quantification. RESULTS Despite normal histological maturation assessed by conventional criteria, 8/10 hydrosalpinx cases yielded an epithelial HSCORE of <0.7, which was below the accepted threshold. Following salpingectomy, luminal endometrial epithelium demonstrated a significantly increased alpha(v)beta3 integrin expression (Wilcoxon's signed rank test, P = 0.017). Although the mean HSCORE for glandular epithelia improved, it failed to reach statistical significance. Ultrasound visible hydrosalpinges (n = 5) and non-visible cases (n = 5) were also compared. However, neither the pre-treatment integrin expression, nor the postoperative improvement were significantly different between these groups. CONCLUSIONS We conclude that the surgical treatment of communicating hydrosalpinges may improve endometrial receptivity as assessed by alpha(v)beta3 integrin expression. Women with hydrosalpinges may undergo endometrial evaluation by the molecular markers of implantation, such as alpha(v)beta3 integrin. This evaluation may be decisive in determining the optimal management of cases, and may also be used to assess the efficacy of the treatment. The expression of the implantation markers should be correlated with implantation and clinical pregnancy rates in IVF-embryo transfer programs.
Bacterial and viral etiology of severe infection in children less than three months old in the highlands of Papua New Guinea.

OBJECTIVE Determine the bacterial and viral etiology of severe infection in young Papua New Guinean infants as part of a multicenter study in four developing countries aimed at improving case management guidelines. METHODS Between March, 1991, and April, 1993, children aged <3 months were recruited at the outpatient department of Goroka Base Hospital, Papua New Guinea (PNG). Children with pre-defined inclusion criteria were enrolled, a history was taken and clinical examination was performed. Blood and urine were collected from children with signs suggestive of severe disease together with eye, umbilical and pernasal swabs as appropriate. Nasopharyngeal aspirates (NPAs) were collected from children with and without signs of severe disease for identification of viruses and Chlamydia trachomatis by direct fluorescent antibody staining. RESULTS 3280 infants were triaged and 2168 enrolled, among whom 968 had signs suggestive of severe disease. Group A Streptococcus (Streptococcus pyogenes) and Staphylococcus aureus were the most important bacterial pathogens isolated from children < 1 month old with severe infections, and Streptococcus pneumoniae, S. pyogenes and Staphylococcus aureus were most important in older children. Of 292 eye swabs 19 (7%) grew Neisseria gonorrhoeae. Of 116 umbilical swabs 51 (44%) grew S. pyogenes and 45 (39%) grew Staphylococcus aureus. Respiratory syncytial virus was the most important viral cause of acute lower respiratory infection. CONCLUSIONS S. pyogenes, S. pneumoniae and Staphylococcus aureus are important causes of severe infection in young children in the PNG highlands. It is necessary to improve access to clean water, promote hand-washing in the hospital and at home and investigate further the use of maternal immunization for the prevention of severe disease in young infants.
Present Glaciers and Their Dynamics in the Arid Parts of the Altai Mountains

This research is based on multiyear in-situ observations, analysis of satellite and aerial imagery, meteorological data, and mass balance index calculations. Presently, 659 glaciers cover a total area of 322.1 km2. We identified four favorable, two neutral, and five unfavorable longer intervals of glacier development since 1940. A decelerating of glacial retreat took place in the 1960s and in the late 1980s/early 1990s. The strong decline in glacial mass between 1995 and 2009 resulted in a fast reduction of the glacial area (0.9% year−1 on the northern slope of Tavan Bogd, 1.5% year−1 at Mongun-Taiga), mostly due to the degradation of small glaciers; after 2009, the glacial loss slowed down. Large valley glaciers behaved asynchronously until recently, when their retreat accelerated rapidly reaching in some cases over 40 m∙year−1. Degradation of the accumulation zone and separation of the debris-covered parts of the glaciers are characteristic for the glacial retreat in the region of research. The time of reaction of the fronts of four valley glaciers of Mongun-Taiga and the northern slope of Tavan Bogd on climatic fluctuations is estimated between 11 and 20 years. Over the next decade, high rates of glacial degradation are expected.
The Human Microbiome and I-Cubed: A Modern Medical Paradigm

Background: Over the past decade, there has been recognition of the importance of the human microbiome. Beyond improved microbial cataloguing through high- throughput genetic sequencing, we have learned that human beings are superorganisms integrating the identity, function and immunity of resident bacterial, while prepared throughout own innate and adaptive immune systems, to deal with invading organisms. Hypothesis: In keeping with the dynamic relation of infection, immunity and inflammation contained in I-Cubed, illness arises when protective immunity becomes the source of autoimmunity, conditioned by environmental and genetic factors. Results: This paradigm explains the etiopathogenesis of diverse medical (type 1 diabetes, spondyloarthropathy), neurologic (Lyme neuroborreliosis), and neuropsychiatric disorders (PANDAS, and autism spectrum disorders). Conclusion: Successful treatments employing immune-modulatory therapy may be employed. Public health officials will be called upon to guide the public’s understanding and mitigate the risk of disorders that result from the interplay of the human microbiome and I-Cubed.
ANTEROVENTRAL WALL OF THE THIRD VENTRICLE AND DORSAL LAMINA TERMINALIS: HEADQUARTERS FOR CONTROL OF BODY FLUID HOMEOSTASIS?

1. The subfornical organ, median preoptic nucleus and the organum vasculosum of the lamina terminalis (OVLT) are a series of structures situated in the anterior wall of the third ventricle and form the lamina terminalis. The OVLT and ventral part of the median preoptic nucleus are part of a region known as the anteroventral third ventricle region.
Enhanced Development of Azoxymethane-Induced Colonic Preneoplastic Lesions in Hypertensive Rats

Metabolic syndrome is associated with an increased risk of colorectal cancer. This study investigated the impact of hypertension, a component of metabolic syndrome, on azoxymethane (AOM)-induced colorectal carcinogenesis using SHRSP/Izm (SHRSP) non-diabetic/hypertensive rats and SHRSP.Z-Leprfa/IzmDmcr (SHRSP-ZF) diabetic/hypertensive rats. Male 6-week-old SHRSP, SHRSP-ZF, and control non-diabetic/normotensive Wister Kyoto/Izm (WKY) rats were given 2 weekly intraperitoneal injections of AOM (20 mg/kg body weight). Two weeks after the last injection of AOM, the SHRSP and SHRSP-ZF rats became hypertensive compared to the control WKY rats. Serum levels of angiotensin-II, the active product of the renin-angiotensin system, were elevated in both SHRSP and SHRSP-ZF rats, but only the SHRSP-ZF rats developed insulin resistance, dyslipidemia, and hyperleptinemia and exhibited an increase in adipose tissue. The development of AOM-induced colonic preneoplastic lesions and aberrant crypts foci, was significantly accelerated in both SHRSP and SHRSP-ZF hypertensive rats, compared to WKY normotensive rats. Furthermore, induction of oxidative stress and exacerbation of inflammation were observed in the colonic mucosa and systemically in SHRSP and SHRSP-ZF rats. Our findings suggest that hypertension plays a role in the early stage of colorectal carcinogenesis by inducing oxidative stress and chronic inflammation, which might be associated with activation of the renin-angiotensin system.
Glucose‐responsive insulin‐producing cells from stem cells

Recent success with immunosuppression following islet cell transplantation offers hope that a cell transplantation treatment for type 1 (juvenile) diabetes may be possible if sufficient quantities of safe and effective cells can be produced. For the treatment of type 1 diabetes, the two therapeutically essential functions are the ability to monitor blood glucose levels and the production of corresponding and sufficient levels of mature insulin to maintain glycemic control. Stem cells can replicate themselves and produce cells that take on more specialized functions. If a source of stem cells capable of yielding glucose‐responsive insulin‐producing (GRIP) cells can be identified, then transplantation‐based treatment for type 1 diabetes may become widely available. Currently, stem cells from embryonic and adult sources are being investigated for their ability to proliferate and differentiate into cells with GRIP function. Human embryonic pluripotent stem cells, commonly referred to as embryonic stem (ES) cells and embryonic germ (EG) cells, have received significant attention owing to their broad capacity to differentiate and ability to proliferate well in culture. Their application to diabetes research is of particular promise, as it has been demonstrated that mouse ES cells are capable of producing cells able to normalize glucose levels of diabetic mice, and human ES cells can differentiate into cells capable of insulin production. Cells with GRIP function have also been derived from stem cells residing in adult organisms, here referred to as endogenous stem cell sources. Independent of source, stem cells capable of producing cells with GRIP function may provide a widely available cell transplantation treatment for type 1 diabetes. Copyright © 2002 John Wiley & Sons, Ltd.
Breast Cancer Patients with Progesterone Receptor PR-A-Rich Tumors Have Poorer Disease-Free Survival Rates

Purpose: No study has yet analyzed whether changes in relative expression levels of progesterone receptor (PR) isoforms A and B in human breast tumors have significance in predicting clinical outcome. Human PRs are ligand-activated nuclear transcription factors that mediate progesterone action. Their presence in breast tumors is used to predict functional estrogen receptors (ERs) and, therefore, also to predict the likelihood of response to endocrine therapies and disease prognosis. The two PR isoforms, PR-A and PR-B, possess different in vitro and in vivo activities, suggesting that in tumors, the ratio of their expression may control hormone responsiveness. In general, PR-B are strong transcriptional activators, whereas PR-A can act as dominant repressors of PR-B and ER. Thus their balance may affect tamoxifen response in breast cancers. Experimental Design: To determine whether differential expression of the PR isoforms is associated with clinical outcome and hormonal responsiveness, PR-A and PR-B were measured by immunoblot analysis of cell lysates from 297 axillary node-positive breast tumors. Results: Expression of the two isoforms correlated with each other, as well as with ER. Additional analyses revealed that patients with PR-positive tumors but high PR-A:PR-B ratios, which were often caused by high PR-A levels, were 2.76 times more likely to relapse than patients with lower ratios, indicating resistance to tamoxifen. Conclusions: This study suggests that knowledge of the PR-A:PR-B ratio may identify a subgroup of ER-positive/PR-positive patients with node-positive breast cancer that benefit poorly from endocrine therapy.