Miracle-dz/UniFAR-FTUs huggingface dataset:
Combined antibiotic (metronidazole) and mechanical treatment effects on the subgingival bacterial flora of sites with recurrent periodontal disease.

5 patients in maintenance, 1-3 years after periodontal therapy who showed sites with reinfected pockets and bleeding despite regular recall visits were selected. Darkfield microscopy from 3 sites in each patient showed an average of 41% spirochetes and 21% motile rods. Probing depths ranged from 7 to 9 mm and loss of clinical attachment from 6 to 13 mm in these sites. The patients were given 3 times 250 mg/day of metronidazole (Flagyl) for 10 days. Darkfield microscopy and microbiological cultures of the subgingival plaque were performed twice prior to the study, at the end of the medication and after 3 weeks, 3 and 6 months. The plaque and gingival indices, probing depth and loss of clinical attachment were recorded. During the medication and at 3 and 6 months, the teeth were scaled and root planed. The samples were obtained with 3 paper points and cultured anaerobically in the glove box on non-selective and selective media and representative bacterial colonies identified by aerobic growth, gram stain and rapid biochemical tests. Presumptive pathogenic micro-organisms including Bacteroides were identified. The % of spirochetes, motile rods and non-motile bacteria were enumerated by darkfield microscopy. The clinical results show that administration of metronidazole and repeated root planing significantly decreased gingival inflammation, probing depth and loss of clinical attachment in reinfected sites. After treatment, these sites harbored significantly less spirochetes and more non-motile bacteria, while motile rods tended to return to baseline levels with time. The combined antibiotic and mechanical therapy resulted in a statistically significant decrease of gram-negative rods, Fusobacteria and Bacteroides gingivalis over 6 months. (ABSTRACT TRUNCATED AT 250 WORDS)
Communication Relationship Satisfaction and Organizational Commitment

This exploratory study examines the relationship between communication relationship satisfaction (CRS) and organizational commitment. CRS was measured by organizational communication relationship (OCR) instrument developed by the International Communication Association (ICA). Organizational commitment was measured by Porter, Steers, Mowday and Boulian's (1974) scale. Data were obtained from 122 white-collar employees in an engineering company through a paper-and-pencil questionnaire. A factor analysis of the ICA-OCR instrument indicated 4 factors but only 2 (top management and supervisor relationships) were considered appropriate for the study. Our results indicate that top management relationships relate more closely to organizational commitment than either the global CRS or supervisor relationship. The implication of our findings for managers and directions for future research are indicated.
Lightning Surge Response Of Transmission Towers

A sensitivity study of HV and EHV lightning performance shows that surge response characteristics of towers and lines are as important as the footing response. Tower travel time has a very large sensitivity for taller double-circuit lines. Existing methods for analysis of tower and line response have considerable uncertainty. This uncertainty is resolved by extensions to travelling- wave analysis combined with experimental verification. New equations for tower surge impedance and tower travel time are proposed to deal with the most common situation of a midspan stroke to the skywire.
Alternative Schools Serving Students With and Without Disabilities: What Are the Current Issues and Challenges?

Abstract The University of Minnesota's Alternative School Research Project, a directed research study funded by the U.S. Department of Education's Office of Special Education Programs, is in the process of conducting research on alternative schools across the country. Special emphasis is given to studying the extent to which and how students with disabilities are being served. Information in this article is a synthesis of data gathered during the 1 st year of this study and is drawn from interviews with state directors of special education, material on alternative education compiled from each state, and other relevant research and literature on alternative education. Critical issues and challenges for alternative educators and administrators are identified and discussed. Issues focus on governance and policies guiding the operation of alternative schools, the purpose of alternative schools, student needs and implications for service, staffing and instruction, maintaining high expectations and high standards, and measuring outcomes and effectiveness. The article contains a list of questions that can be used to help educators identify and address key issues in their alternative settings in order to promote successful school experiences for students with and without disabilities.
Small-World Internet Topologies: Possible Causes and Implications on Scalability of End-System Multicast

Recent work has shown the prevalence of small-world phenomena [28] in many networks. Small-world graphs exhibit a high degree of clustering, yet have typically short path lengths between arbitrary vertices. Internet AS-level graphs have been shown to exhibit small-world behaviors [9]. In this paper, we show that both Internet AS-level and routerlevel graphs exhibit small-world behavior. We attribute such behavior to two possible causes–namely the high variability of vertex degree distributions (which were found to follow approximately a power law [15]) and the preference of vertices to have local connections. We show that both factors contribute with different relative degrees to the small-world behavior of AS-level and router-level topologies. Our findings underscore the inefficacy of the Barabasi-Albert model [6] in explaining the growth process of the Internet, and provide a basis for more promising approaches to the development of Internet topology generators. We present such a generator and show the resemblance of the synthetic graphs it generates to real Internet AS-level and router-level graphs. Using these graphs, we have examined how small-world behaviors affect the scalability of end-system multicast. Our findings indicate that lower variability of vertex degree and stronger preference for local connectivity in small-world graphs results in slower network neighborhood expansion, and in longer average path length between two arbitrary vertices, which in turn results in better scaling of end system multicast.
Macaque Parieto-Insular Vestibular Cortex: Responses to Self-Motion and Optic Flow

The parieto-insular vestibular cortex (PIVC) is thought to contain an important representation of vestibular information. Here we describe responses of macaque PIVC neurons to three-dimensional (3D) vestibular and optic flow stimulation. We found robust vestibular responses to both translational and rotational stimuli in the retroinsular (Ri) and adjacent secondary somatosensory (S2) cortices. PIVC neurons did not respond to optic flow stimulation, and vestibular responses were similar in darkness and during visual fixation. Cells in the upper bank and tip of the lateral sulcus (Ri and S2) responded to sinusoidal vestibular stimuli with modulation at the first harmonic frequency and were directionally tuned. Cells in the lower bank of the lateral sulcus (mostly Ri) often modulated at the second harmonic frequency and showed either bimodal spatial tuning or no tuning at all. All directions of 3D motion were represented in PIVC, with direction preferences distributed approximately uniformly for translation, but showing a preference for roll rotation. Spatiotemporal profiles of responses to translation revealed that half of PIVC cells followed the linear velocity profile of the stimulus, one-quarter carried signals related to linear acceleration (in the form of two peaks of direction selectivity separated in time), and a few neurons followed the derivative of linear acceleration (jerk). In contrast, mainly velocity-coding cells were found in response to rotation. Thus, PIVC comprises a large functional region in macaque areas Ri and S2, with robust responses to 3D rotation and translation, but is unlikely to play a significant role in visual/vestibular integration for self-motion perception.
The European venture capital landscape: an EIF perspective. Volume I: The impact of EIF on the VC ecosystem

In the past 20 years, the European Investment Fund (EIF, the Fund) has been the leading public provider of risk capital, and in particular of venture capital (VC), to young and innovative European startups. VC is an essential source for startups to achieve growth and create value through innovation, and although it should not be seen as a substitute to traditional banking finance (since it serves only a specific and restricted class of firms), research has shown that the innovativeness, productivity and development of the overall economy reap the returns of a thriving venture capital ecosystem. EIF's established reputation in the European VC market is substantiated by its significant role in European investment and fundraising activity. In this paper we estimate that the investment activity backed by EIF represented 41% of total investments in Europe in 2014 (29% in 2007). The share directly attributable to EIF amounts to 10% (5% in 2007), hinting to the significant leverage that characterises EIF-backed investments. Moreover we estimate that fundraising volumes backed by EIF in 2014 amount to 45% of the overall volumes collected by European VC investors (36% in 2007), against a share directly attributable to EIF totalling 12% (5% in 2007).
Protein‐based virtual screening of chemical databases. II. Are homology models of g‐protein coupled receptors suitable targets?

The aim of the current study is to investigate whether homology models of G‐Protein‐Coupled Receptors (GPCRs) that are based on bovine rhodopsin are reliable enough to be used for virtual screening of chemical databases. Starting from the recently described 2.8 Å‐resolution X‐ray structure of bovine rhodopsin, homology models of an “antagonist‐bound” form of three human GPCRs (dopamine D3 receptor, muscarinic M1 receptor, vasopressin V1a receptor) were constructed. The homology models were used to screen three‐dimensional databases using three different docking programs (Dock, FlexX, Gold) in combination with seven scoring functions (ChemScore, Dock, FlexX, Fresno, Gold, Pmf, Score). Rhodopsin‐based homology models turned out to be suitable, indeed, for virtual screening since known antagonists seeded in the test databases could be distinguished from randomly chosen molecules. However, such models are not accurate enough for retrieving known agonists. To generate receptor models better suited for agonist screening, we developed a new knowledge‐ and pharmacophore‐based modeling procedure that might partly simulate the conformational changes occurring in the active site during receptor activation. Receptor coordinates generated by this new procedure are now suitable for agonist screening. We thus propose two alternative strategies for the virtual screening of GPCR ligands, relying on a different set of receptor coordinates (antagonist‐bound and agonist‐bound states). Proteins 2003;50:5–25. © 2002 Wiley‐Liss, Inc.
Strategy, strategists and fantasy: a dialogic constructionist perspective

Purpose - The purpose of this paper is to contribute a constructionist perspective to debates in the strategy literature about the ways in which managers conduct strategy work. The authors build on observations that fantasy plays a central role in strategy work and aim to focus on the ways in which fantasies of self and other operate in the identity work of participants in the process of developing strategy. Design/methodology/approach - The study presents an inductive approach based on extended participant observation in two different organizations. Each engagement lasted about three years and the analysis is based on data gathered in meetings, workshops, focus groups, interviews and other informal settings. Findings - The paper presents four different types of fantasy, which were observed in the data set. These fantasies are labeled: helpful pairing; the arms race; the eternal optimist and the merchant of doom. It is also suggested that there are three useful dimensions that might be used to unpack the ways in which fantasies operate. These are role playing and role taking; temporal place and associated value; the relationship between fantasy and evidence. Research limitations/implications - The authors propose that future research on strategy should entail an understanding of the role of fantasy in what people say and do. Originality/value - The paper offers four types of fantasy construction as a contribution to the extant literature and three analytical dimensions which can be used to consider the ways in which fantasy operates in the identity work of strategists.
Assessment of borderline pathology using the Inventory of Interpersonal Problems Circumplex Scales (IIP-C): A comparison of clinical samples.

We examined the interpersonal functioning of 74 outpatients at a university-based community clinic in a naturalistic study. Twenty-three individuals diagnosed with borderline pathology (BP) were compared with a non-BP clinical control group (n = 51). Based on previous research, we hypothesized that individuals with BP would report significantly greater overall interpersonal distress as well as greater problems associated with non-assertive, overly accommodating, self-sacrificing and intrusive/needy relational behaviours. We found that individuals with BP reported greater interpersonal distress in regard to overly accommodating, self-sacrificing and intrusive/needy relational behaviours. A trend was observed in regard to differences in overall interpersonal distress. Evaluation of the group-level circumplex profiles confirmed group homogeneity in interpersonal problem endorsement, supporting the aggregate descriptions of interpersonal style as representative of individuals within each group. The clinical utility of our results, specifically in regard to psychotherapy process and outcome as well as therapeutic alliance, will be discussed. Copyright © 2007 John Wiley & Sons, Ltd.
Hypercalcemic Disorders in Children

Hypercalcemia is defined as a serum calcium concentration that is greater than two standard deviations above the normal mean, which in children may vary with age and sex, reflecting changes in the normal physiology at each developmental stage. Hypercalcemic disorders in children may present with hypotonia, poor feeding, vomiting, constipation, abdominal pain, lethargy, polyuria, dehydration, failure to thrive, and seizures. In severe cases renal failure, pancreatitis and reduced consciousness may also occur and older children and adolescents may present with psychiatric symptoms. The causes of hypercalcemia in children can be classified as parathyroid hormone (PTH)‐dependent or PTH‐independent, and may be congenital or acquired. PTH‐independent hypercalcemia, ie, hypercalcemia associated with a suppressed PTH, is commoner in children than PTH‐dependent hypercalcemia. Acquired causes of PTH‐independent hypercalcemia in children include hypervitaminosis; granulomatous disorders, and endocrinopathies. Congenital syndromes associated with PTH‐independent hypercalcemia include idiopathic infantile hypercalcemia (IIH), William's syndrome, and inborn errors of metabolism. PTH‐dependent hypercalcemia is usually caused by parathyroid tumors, which may give rise to primary hyperparathyroidism (PHPT) or tertiary hyperparathyroidism, which usually arises in association with chronic renal failure and in the treatment of hypophosphatemic rickets. Acquired causes of PTH‐dependent hypercalcemia in neonates include maternal hypocalcemia and extracorporeal membrane oxygenation. PHPT usually occurs as an isolated nonsyndromic and nonhereditary endocrinopathy, but may also occur as a hereditary hypercalcemic disorder such as familial hypocalciuric hypercalcemia, neonatal severe primary hyperparathyroidism, and familial isolated primary hyperparathyroidism, and less commonly, as part of inherited complex syndromic disorders such as multiple endocrine neoplasia (MEN). Advances in identifying the genetic causes have resulted in increased understanding of the underlying biological pathways and improvements in diagnosis. The management of symptomatic hypercalcemia includes interventions such as fluids, antiresorptive medications, and parathyroid surgery. This article presents a clinical, biochemical, and genetic approach to investigating the causes of pediatric hypercalcemia. © 2017 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.
Synaptic Basis of Cortical Persistent Activity: the Importance of NMDA Receptors to Working Memory

Delay-period activity of prefrontal cortical cells, the neural hallmark of working memory, is generally assumed to be sustained by reverberating synaptic excitation in the prefrontal cortical circuit. Previous model studies of working memory emphasized the high efficacy of recurrent synapses, but did not investigate the role of temporal synaptic dynamics. In this theoretical work, I show that biophysical properties of cortical synaptic transmission are important to the generation and stabilization of a network persistent state. This is especially the case when negative feedback mechanisms (such as spike-frequency adaptation, feedback shunting inhibition, and short-term depression of recurrent excitatory synapses) are included so that the neural firing rates are controlled within a physiological range (10–50 Hz), in spite of the exuberant recurrent excitation. Moreover, it is found that, to achieve a stable persistent state, recurrent excitatory synapses must be dominated by a slow component. If neuronal firings are asynchronous, the synaptic decay time constant needs to be comparable to that of the negative feedback; whereas in the case of partially synchronous dynamics, it needs to be comparable to a typical interspike interval (or oscillation period). Slow synaptic current kinetics also leads to the saturation of synaptic drive at high firing frequencies that contributes to rate control in a persistent state. For these reasons the slow NMDA receptor-mediated synaptic transmission is likely required for sustaining persistent network activity at low firing rates. This result suggests a critical role of the NMDA receptor channels in normal working memory function of the prefrontal cortex.
Isotopic Compositions of Cometary Matter Returned by Stardust

Hydrogen, carbon, nitrogen, and oxygen isotopic compositions are heterogeneous among comet 81P/Wild 2 particle fragments; however, extreme isotopic anomalies are rare, indicating that the comet is not a pristine aggregate of presolar materials. Nonterrestrial nitrogen and neon isotope ratios suggest that indigenous organic matter and highly volatile materials were successfully collected. Except for a single 17O-enriched circumstellar stardust grain, silicate and oxide minerals have oxygen isotopic compositions consistent with solar system origin. One refractory grain is 16O-enriched, like refractory inclusions in meteorites, suggesting that Wild 2 contains material formed at high temperature in the inner solar system and transported to the Kuiper belt before comet accretion.
Detecting and classifying delay Data Exceptions on communication networks using rule based algorithms

Network performance monitoring is essential for managing a network efficiently and for ensuring reliable operation of the network. Monitored network performance changes reflect events in the network, such as faults, significant changes in usage patterns or planned alterations. Network managers are interested in how and when the performance of a network changes; however it is inefficient to analyse all the data resulting from the monitoring operation manually. In this paper a rule based algorithm to automate detection of the changes in one of the network performance parameters, namely delay, is presented and described in detail. The nature of the delay pattern in a commercial communication network was the key issue in developing this algorithm. The approach was tested with monitored delay data generated from three different networks and showed good results. Also, the algorithm was tested with sets of delay data which have been already input to a previously developed detector based on a different approach, and the results between the two detectors are compared. In addition to a noticeable improvement in detection performance, the new approach provides more generality and independency of the source of the delay data, making the approach generally applicable to other networks. Copyright © 2004 John Wiley & Sons, Ltd.
Estimating disparity and occlusions in stereo video sequences

We propose an algorithm for estimating disparity and occlusion in stereo video sequences. The algorithm defines a prior on sequences of disparity maps using a 3D Markov random field, and approximately computes the MAP estimate for the disparity sequence using loopy belief propagation. In contrast to previous work on temporal stereo, the algorithm (i) correctly models half-occlusions - scene points visible in one camera but not the other - and (ii) enforces the so-called "monotonicity constraint" on the boundary of half-occluded regions. The algorithm is also able to exploit temporal coherence more appropriately than many previous approaches to temporal stereo, by employing additional states in the Markov random field. These additional states permit rudimentary motion estimation to be performed as part of the belief propagation, thus improving the quality of temporal inference. Parameters of the algorithm are learned from the ground truth disparities of a real stereo sequence. Qualitative results are shown on real sequences, including comparisons with competing approaches, and the performance of the algorithm is assessed quantitatively using the ground truth data.
The joint adequacy of AGC and primary frequency response in single balancing authority systems

Summary form only given. This paper generalizes previous work on automatic generation control (AGC) gain in a single balancing authority system. In previous work, a control performance standard 1 (CPS1)-compliant AGC gain for a single balancing authority interconnection was proposed, assuming that frequency response can be decoupled from AGC dynamics by widening governor dead bands. However, current practices suggest that widening dead bands may not be a wise course to take as it may deteriorate primary frequency response. This paper formulates sufficient conditions for the adequacy of the joint operation of AGC control and primary frequency response to be consistent with frequency response adequacy. Historical data and a simulation of ERCOT are presented to show numerical results.
Image-embodied Knowledge Representation Learning

Entity images could provide significant visual information for knowledge representation learning. Most conventional methods learn knowledge representations merely from structured triples, ignoring rich visual information extracted from entity images. In this paper, we propose a novel Image-embodied Knowledge Representation Learning model (IKRL), where knowledge representations are learned with both triple facts and images. More specifically, we first construct representations for all images of an entity with a neural image encoder. These image representations are then integrated into an aggregated image-based representation via an attention-based method. We evaluate our IKRL models on knowledge graph completion and triple classification. Experimental results demonstrate that our models outperform all baselines on both tasks, which indicates the significance of visual information for knowledge representations and the capability of our models in learning knowledge representations with images.