Miracle-dz/UniFAR-FTUs huggingface dataset:
Western psychotherapeutic practice: Engaging Aboriginal people in culturally appropriate and respectful ways

Until recently the majority of psychologists in Australia have been confronted by the lack of information relating to culturally appropriate methods of engagement and therapy with Aboriginal clients. Findings from a qualitative study undertaken in Western Australia indicated that Aboriginal conceptualisations of mental health appear more holistic and contain elements that are both cultural and spiritual. The extent of these differences in conceptualisations from Western psychiatry and psychology are so vast that the mental health interventions need to be reconsidered. Extending from an Aboriginal mental health model are traditional treatments that endeavour to address the cultural and spiritual components of the mental illness. Findings from the study indicated that these treatments appeared to be hierarchically organised, depending on cause, severity, type of practitioner required and treatment. The findings also indicated that Aboriginal people generally seek traditional interpretations and treatment of.
Phosphorylation of Nucleoside-Metallacarborane and Carborane Conjugates by Nucleoside Kinases

A library of purine and pyrimidine nucleosides modified with carborane or metallacarborane boron clusters at different locations, consisting of new molecules as well as already described compounds, was prepared. The compounds were tested as substrates for human deoxynucleoside kinases. Some conjugates, with modification attached to N3 of thymidine via a linker containing the triazole moiety, were efficiently phosphorylated by cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2. Higher phosphorylation levels were observed with thymidine kinase 1, the phosphorylation of nucleosides modified with metallacarboranes was observed for the first time.
Teaching and Research on International Relations and Area Studies

*Extracts from the text of the Inaugural Speech delivered to the Seventh Rajasthan Political Science Conference, Beawar (Rajasthan, India), on 25 February 1978. **Dr Rajan is at present Professor of International Organization and Head of the Centre for International Politics and Organization at the School. He was Director of the School during the years 1965-71. When, soon after its establishment some years ago, the Indian Council for Social Science Research (ICSSR) spelt out the scope of its activities, I was surprised to find International Relations being bracketed with Political Science; there was no reference to Area Studies either in the fields to be
Religious Devoutness Construed as Pathology: the Myth of 'Religious Mania'

Contemporary Eurocentric norms and values continue to be superimposed onto various deviant religious convictions and expressions occurring both transculturally and transhistorically. Value judgments as to what constitutes acceptable forms of emotional expression and worship are often made under the insidious neutral guise of science, which is dominated by narrow, restrictive Western concepts of normality. Western-trained social scientists must be more sensitive to the historical and ethno- graphic records and the caveats of imposing moral proscriptions onto unfamiliar or exotic symbol systems.
Design and analysis of fMRI studies with neurologically impaired patients

Functional neuroimaging can be used to characterize two types of abnormality in patients with neurological deficits: abnormal functional segregation and abnormal functional integration. In this paper we consider the factors that influence the experimental design, analysis, and interpretation of such studies. With respect to experimental design, we emphasize that: 1) task selection is constrained to tasks the patient is able to perform correctly, and 2) the most sensitive designs entail presenting stimuli of the same type close together. In terms of data preprocessing, prior to statistical analysis, we note that structural pathology may call for constraints on nonlinear transformations, used by spatial normalization, to prevent distortion of intact tissue. This means that one may have to increase spatial smoothing to reduce the impact of inaccurate normalization. Important issues in statistical modeling concern the first level of analysis (estimation of activation within subject), which has to distinguish correct from incorrect responses. At the second level (between subjects), inference should be based on between‐subjects variance. Provided that these and other constraints are met, deficits in functional segregation are indicated when activation in one or a set of regions is higher or lower in patients relative to control subjects. In contrast, deficits in functional integration are implied when the influence of one brain region on another is stronger or weaker in patients relative to control subjects. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.
Dracula as action researcher

Abstract Over the last few years the teacher education program at the University of Alberta, Edmonton, has been undergoing a series of changes. Committed to providing a closer linkage between university course work and school practicum placements, the program has increasingly emphasized the interpretation of student-teacher experiences in relation to their own personal backgrounds and university course work. Framed as ‘reflective practice’, journal writing and personal reflective papers are examples of course work that is taking on greater importance in the teacher education program. For the students and course instructors ‘reflective practice’ raises some challenging questions. How authentic is ‘reflective practice’? What are the ethical issues raised by course instructors asking students to reflect on their practice in schools? Does the university, with its potential power to ‘pass or fail’ student teachers, have a legitimate right to ask students to become partners with course instructors in reflective.
The value systems of deaf and hearing adolescents

Abstract This article uses data concerning the popularity of value items among deaf and hearing adolescents to consider the extent of marginalization of d/Deaf people. The popularity of values in a sample of deaf adolescents and in a large sample of hearing adolescents is investigated using logistic regression and multilevel modelling. In this way it is possible to show where the value systems of deaf adolescents differ from each other, where they resemble hearing adolescents closely, where they resemble a minority of hearing adolescents and where they are significantly different from the value systems of the hearing adolescents. Marginalization is not so extensive as to cut off the deaf youngsters from widespread tendencies in adolescence and prevent them showing gender differences found among hearing adolescents. At the same time the deaf participants cannot be regarded as absorbed into the adolescent population with any deaf identity diffused. The evidence from this study supports the need to recognize a unique difference in deaf people. However, deaf adolescents cannot avoid dealings with the dominant language. Medical services in liaison with social services offer strategies and resources for dealing with the dominant language. In this way services can represent acknowledgement of the difference between d/Deaf people and hearing people instead of attempts at denial and assimilation.
Clinical and radiographic findings, treatment, and outcome in cattle with osteochondrosis: 29 cases (1986-1996).

OBJECTIVE To summarize the radiographic and clinical findings, treatment, and outcome in cattle with osteochondrosis diagnosed radiographically. DESIGN Retrospective case series. SAMPLE POPULATION 29 cattle with radiographic evidence of osteochondrosis. PROCEDURES Medical records were reviewed, and owners or referring veterinarians were contacted for outcome assessment. Data were analyzed for potential interactions between osteochondrosis classification (osteochondritis dessicans vs subchondral cyst-like lesions), clinical and radiographic findings, treatment, and outcome, using Fisher's exact test and descriptive statistics. RESULTS Osteochondrosis was associated with young, male, purebred cattle, clinical evidence of lameness, and radiographic evidence of concurrent degenerative joint disease. Osteochondritis dissecans and subchondral cyst-like lesions had similar clinical findings and outcomes but varied significantly in their radiographic distribution among joints. Osteochondrosis often manifests clinically as a unilateral condition, but bilateral lesions were often found (88%) when limbs were radiographically examined. Cattle managed conservatively tended to be culled (within 6 months of diagnosis because of lameness) more often than those managed surgically, despite the lack of treatment bias. CLINICAL IMPLICATIONS Osteochondrosis in cattle is often associated with lameness or degenerative joint disease. Conservative management does not result in a favorable clinical prognosis for long-term, lameness-free survival, and more studies need to be completed to evaluate the efficacy of surgical treatment of osteochondrosis in cattle.
Scalable I/O - A Well-Architected Way to Do Scalable, Secure and Virtualized I/O

Today in both virtualized and non-virtualized systems the entire I/O functionality is based on device drivers. They are central to any system structure; both anecdotal and informed evidence indicates device drivers as a major source of trouble in the classical OS and a source of scaling and performance issues in virtual I/O, due to "trusted intermediary" required for the shared I/O. We propose an architecture which virtualizes the entire I/O subsystem rather than each I/O device, and provides device-independent I/O at higher level of abstraction than the traditional I/O interfaces. In our suggested architecture the system robustness is increased by isolating drivers; efficient and scalable virtualization becomes possible by a complete separation of the I/O and compute function and introducing a protection model that does not require a trusted intermediary for I/O.
Measurement of myocardial blood flow velocity reserve with myocardial contrast echocardiography in patients with suspected coronary artery disease: comparison with quantitative gated Technetium 99m sestamibi single photon emission computed tomography.

BACKGROUND The ability of high and low mechanical index (MI) imaging methods during myocardial contrast echocardiography (MCE) to assess the physiologic significance of coronary stenoses were compared with technetium 99m sestamibi single photon emission computed tomography (SPECT) in patients. METHODS Intermittent ultraharmonic imaging (high MI) and power modulation angio (low MI) were performed during continuous infusions of the echo-enhancing contrast agent, Optison, at rest and after dipyridamole stress in 39 patients. Technetium 99m sestamibi SPECT was performed simultaneously. Images from the 3 apical windows were divided into 6 walls. Myocardial blood flow (MBF) velocity and MBF velocity reserve were quantified from pulsing interval versus acoustic intensity MCE curves in each wall using postprocessed images. RESULTS Approximately 25% of the myocardial walls could not be analyzed from MCE because of artifacts. MBF velocity and MBF derived from both MCE methods increased significantly after dipyridamole in healthy patients (n = 143 and 129 walls for high and low MI, respectively), compared with those with either reversible (n = 11 and 10 walls for high and low MI, respectively) or fixed defects (n = 18 and 14 walls for high and low MI, respectively) on SPECT. Consequently, MBF velocity and MBF reserve were significantly greater for patients with normal perfusion. Receiver operator characteristic curves obtained for MBF velocity reserve provided a sensitivity and specificity of 82% and 87%, respectively, for high MI; versus 64% and 96%, respectively, for low MI imaging after uninterpretable images were excluded from analysis. CONCLUSIONS Both high and low MI MCE imaging techniques can be used to determine the presence of perfusion defects as identified by technetium 99m sestamibi SPECT. Low MI imaging methods have a number of drawbacks that limit its sensitivity compared with high MI techniques.
Prejudice Toward Contemporary Outgroups as a Generalized Attitude

The interrelatedness of attitudes toward homosexuals, Blacks, women, and old people was studied, as well as attitude differences on demographic variables. Three hundred and nine White undergraduates responded to the Homosexual Attitude Scale, The Attitudes Toward Women Scale, Multifactor Racial Attitude Inventory, and two attitudes toward old people scales. Nine of the ten possible intercorrelations were significant beyond the . 01 levels. Prejudice toward quite distinct outgroups appears to be a generalized attitude. Attitude differences were found on the demographic variables of sex, political party, and religion. Women expressed more tolerant attitudes than men toward all four outgroups studied. Republicans were more prejudiced toward homosexuals and women than were Democrats or Independents. Participants who identified themselves as Christians were less supportive of equality between the sexes than were Catholics, Protestants, or those with no religion Christians were also more prejudiced toward homosexuals than were Catholics or those with no religion.
T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation

T cell activation by nonself peptide–major histocompatibility complex (MHC) antigenic complexes can be blocked by particular sequence variants in a process termed T cell receptor antagonism. The inhibition mechanism is not understood, although such variants are encountered in viral infections and may aid immune evasion. Here, we study the effect of antagonist peptides on immunological synapse formation by T cells. This cellular communication process features early integrin engagement and T cell motility arrest, referred to as the “stop signal. ” We find that synapses formed on membranes presenting antagonist–agonist complexes display reduced MHC density, which leads to reduced T cell proliferation that is not overcome by the costimulatory ligands CD48 and B7-1. Most T cells fail to arrest and crawl slowly with a dense ICAM-1 crescent at the leading edge. Similar aberrant patterns of LFA-1/ICAM-1 engagement in live T–B couples correlate with reduced calcium flux and IL-2 secretion. Hence, antagonist peptides selectively disable MHC clustering and the stop signal, whereas LFA-1 valency up-regulation occurs normally.
A Two-Phase Gaming Model for Resource Pricing in Elastic Cloud Environments

With the development of cloud computing, many organizations are deploying their IT infrastructures through cloud platforms so as to provide services for more and more users. Therefore, resource pricing mechanism becomes a key component in these open cloud platforms. In this paper, we propose a gaming theory based cloud resource pricing model, in which a cooperative gaming model is applied to optimize the resource benefits and noncooperative gaming model is used to balance the user’s costs and provider’s benefits. Theoretical analysis is presented to validate the correctness of the proposed gaming model, and extensive experiments are conducted to investigate the effectiveness of the proposed resource pricing mechanism. The results indicate that our resource pricing mechanism outperforms many existing approaches in terms of resource profits and response time, especially when the cloud system is in presence of intensive workloads.
Henri Bergson’s contribution to the invention of a psychology in duration

This article uses the philosophical concepts of Henri Bergson (namely duration, intelligence, and intuition), in order to problematize ways of thinking about psychology, and how psychology produces knowledge. From this perspective, we discuss psychology as a scientific discipline and examine the differences between science and philosophy. In so doing, we deepen the understanding of the concepts of duration, time, and space, in relation to the logics of spatialized time which influence analysis in Human Sciences. We also discuss differences between ways of apprehending knowledge through intelligence and intuition, causing a change in the perspective from which we approach our objects of investigation. Finally, we propose a view of psychology in terms of duration.
A Comparison of Terrain Indices toward Their Ability in Assisting Surface Water Mapping from Sentinel-1 Data

The Sentinel-1 mission provides frequent coverage of global land areas and is hence able to monitor surface water dynamics at a fine spatial resolution better than any other Synthetic Aperture Radar (SAR) mission before. However, SAR data acquired by Sentinel-1 also suffer from terrain effects when being used for mapping surface water, just as other SAR data do. Terrain indices derived from Digital Elevation Models (DEMs) are easy but effective approaches to reduce this kind of interference, considering the close relationship between surface water movement and topography. This study compares two popular terrain indices, namely the Multi-resolution Valley Bottom Flatness (MrVBF) and the Height Above Nearest Drainage (HAND), toward their performance on assisting surface water mapping using Sentinel-1 SAR data. Four study sites with different terrain characteristics were selected to cover a very wide range of topographic conditions. For two of these sites that are floodplain dominated, both normal and flooded scenarios were examined. MrVBF and HAND values for the whole study areas, as well as statistics of these values within water areas were compared. The sensitivity of applying different thresholds for MrVBF and HAND to mask out terrain effect was investigated by adopting quantity disagreement and allocation disagreement as the accuracy indicators. It was found that both indices help improve water mapping, reducing the total disagreement by as much as 1.6%. The HAND index performs slightly better in most of the study cases, with less sensitivity to thresholding. MrVBF classifies low-lying areas with more details, which sometimes makes it more effective in eliminating false water bodies in rugged terrain. It is therefore recommended to use HAND for large scale or global scale water mapping. However, for water detection in complex terrain areas, MrVBF also performs very well.
Association of body mass index with some fertility markers among male partners of infertile couples

Background The available evidence on the role of obesity and body mass index (BMI) on male infertility has been controversial or inconclusive to some extent. Objectives The aim of this study was to investigate the role of BMI on some male-fertility laboratory indicators both among infertile and fertile men in an Iranian population. Methods and materials A total of 159 male patients who had lived as a partner in an infertile couple for at least 1 year, after regular reproductive activity in their married life, and who sought infertility consultation, were investigated. BMI was assessed, and a morning blood sample was taken assessing serum levels of testosterone, sex hormone-binding globulin, prolactin, luteinizing hormone (LH), follicle-stimulating hormone, and estradiol. Semen-analysis parameters were also measured. Results In this study, it was found that the likelihood of oligospermia was increased at higher BMI values. Obese men were found to be 3.5 times more likely to have oligospermia than those with normal BMI. BMI was not found to be associated with mean numeric values of the semen-analysis parameters, including sperm count, sperm morphology, and sperm motility. BMI was not significantly correlated with some hormone levels, such as LH, prolactin, and LH/follicle-stimulating hormone ratio. However, a statistically significant association was observed between BMI and estradiol (P < 0.01), sex hormone-binding globulin (P < 0.001), and also the testosterone/estradiol ratio (P < 0.001). A different pattern of associations in this study was observed when the associations between BMI and sexual hormone levels were compared between fertile and subfertile/infertile men. Conclusion The association explored between BMI and some sexual hormones and semen characteristics, as well as different patterns of this association between fertile and subfertile/infertile men, will be of help to broaden our understanding of the effect of obesity on some male reproductive physiologic characteristics among fertile and infertile men.
Huntingtin toxicity is ameliorated by BAG1 through modulation of its aggregation, degradation and subcellular distribution

Huntington s disease (HD) is a fatal neurodegenerative disorder resulting from an expansion of a polyglutamine stretch in a ubiquitously expressed protein called huntingtin. Intraneuronal inclusion body formation and the accumulation of mutant huntingtin N-terminal fragments in the nucleus are the pathological hallmarks of the disease. It is thought that nuclear localization of mutant huntingtin leads to toxicity, while inclusion body formation exerts a beneficial function of sequestering the toxic fragment.We evaluated the effect of the co-chaperone BAG1 on mutant huntingtin toxicity and investigated its mechanism of action. BAG1 is a multifunctional protein, delivering chaperone-recognized substrates to the proteasome for degradation. It is essential for proper CNS development, it stimulates neuronal differentiation and protects from a variety of apoptotic insults. Here, we show that BAG1 reduces inclusion body formation and accelerates the degradation of mutant huntingtin in a proteasome- and Hsp70-dependant manner. Moreover, it inhibits translocation of mutant huntingtin into the nucleus. This effect can be overcome by overexpression of Siah-1, an E3-ligase negatively regulated by BAG1 and known to be involved in nuclear import of mutant huntingtin. In addition, we observed that BAG1 leads to decreased cellular levels of Siah1. Finally, BAG1 protects from mutant huntingtin induced cell death in vivo and in vitro. In a Drosophila HD model BAG1 significantly ameliorates photoreceptor cell loss and leads to decreased levels of mutant huntingtin fragment. In summary, we present BAG1 as a novel therapeutic tool modulating key steps in huntingtin toxicity in vitro and ameliorating huntingtin toxicity in vivo.
Selecting Pedagogical Protocols Using SOM

During the first courses of the Computer Engineering undergraduate Program at the University of Buenos Aires, the number of human tutors in Programming Area is usually not enough: the students/tutors ratio is very high and there is a great heterogeneity in the acquired knowledge and background of students. The main idea behind this paper is to describe a system that could emulate a human tutor. Thus, the tutor will be able to provide student with a high level of flexibility for the selection of the most adequate tutorial type. This could be a feasible solution to the stated problem. But a tutorial system should not only emulate the human tutor but also it should be designed from an epistemological perspective concerning what teaching Programming really means. This is specially important in an Engineering course due to the required profile and identity of the future engineer. The stated solution implements a series of artificial neural networks to determine if there is a relationship between the given initial population of students learning preferences and the different tutoring types. A series of experiences were carried out in order to validate the current model.