Miracle-dz/UniFAR-FTUs huggingface dataset:
Irigaray and Lyotard: Birth, Infancy, and Metaphysics

This paper examines the ways in which Luce Irigaray and Jean‐François Lyotard critique western metaphysics by drawing on notions of birth and infancy. It shows how both thinkers position birth as an event of beginning that can be reaffirmed in every act of initiation and recommencement. Irigaray's reading of Diotima's speech from Plato's Symposium is positioned as a key text for this project alongside a number of essays by Lyotard in which he explores the potency of infancy as the condition of philosophy itself. Despite this potency, however, Lyotard suggests that metaphysics is haunted by a melancholia that is inseparable from the limits of thought. I argue that Irigaray is able both to explain why western metaphysics is constitutively melancholic and to offer a shift in perspective that means we are not inevitably condemned to melancholia. The paper concludes that while Lyotard's account of infancy challenges the terms of western metaphysics from within, Irigaray's reassessment of our beginnings in birth offers the possibility of an alternative metaphysical horizon.
Abide with me: religious group identification among older adults promotes health and well-being by maintaining multiple group memberships

Objectives: Aging is associated with deterioration in health and well-being, but previous research suggests that this can be attenuated by maintaining group memberships and the valued social identities associated with them. In this regard, religious identification may be especially beneficial in helping individuals withstand the challenges of aging, partly because religious identity serves as a basis for a wider social network of other group memberships. This paper aims to examine relationships between religion (identification and group membership) and well-being among older adults. The contribution of having and maintaining multiple group memberships in mediating these relationships is assessed, and also compared to patterns associated with other group memberships (social and exercise). Method: Study 1 (N = 42) surveyed older adults living in residential care homes in Canada, who completed measures of religious identity, other group memberships, and depression. Study 2 (N = 7021) longitudinally assessed older adults in the UK on similar measures, but with the addition of perceived physical health. Results: In Study 1, religious identification was associated with fewer depressive symptoms, and membership in multiple groups mediated that relationship. However, no relationships between social or exercise groups and mental health were evident. Study 2 replicated these patterns, but additionally, maintaining multiple group memberships over time partially mediated the relationship between religious group membership and physical health. Conclusion: Together these findings suggest that religious social networks are an especially valuable source of social capital among older adults, supporting well-being directly and by promoting additional group memberships (including those that are non-religious).
Impact of Amino Acid Mutations in PB2, PB1-F2, and NS1 on the Replication and Pathogenicity of Pandemic (H1N1) 2009 Influenza Viruses

ABSTRACT Here, we assessed the effects of PB1-F2 and NS1 mutations known to increase the pathogenicity of influenza viruses on the replication and pathogenicity in mice of pandemic (H1N1) 2009 influenza viruses. We also characterized viruses possessing a PB1-F2 mutation that was recently identified in pandemic (H1N1) 2009 influenza virus isolates, with and without simultaneous mutations in PB2 and NS1. Our results suggest that some NS1 mutations and the newly identified PB1-F2 mutation have the potential to increase the replication and/or pathogenicity of pandemic (H1N1) 2009 influenza viruses.
The baryonic mass-velocity relation: clues to feedback processes during structure formation and the cosmic baryon inventory

We show that a global relation between baryonic mass and virial velocity can be constructed from the scale of dwarf galaxies up to that of rich galaxy clusters. The slope of this relation is close to that expected if dark matter haloes form in the standard hierarchical cosmogony and capture a universal baryon fraction, once the details of halo structure and the adiabatic contraction of haloes due to cooling gas are taken into account. The scatter and deficiency of baryons within low-mass haloes (V vir < 50 km s -1 ) are consistent with the expected suppression of gas accretion by photoevaporation due to the cosmic UV background at high redshift. The data are not consistent with significant gas removal from strong supernovae winds unless the velocities of galaxies measured from their gas kinematics are significantly lower than the true halo velocities for objects with V vir < 100 km s -1 . Thus models such as A cold dark matter (ACDM) with a steep mass function of haloes may find it difficult to reproduce the baryonic mass-velocity relation presented here whilst at the same time reproducing the flat luminosity/H I function of galaxies. Galaxies hold about 10 per cent of the baryons in the Universe, which is close to the collapsed mass fraction expected within hierarchical models on these scales, suggesting a high efficiency for galaxy formation. Most of the baryons are expected to be evenly distributed between diffuse intergalactic gas in low-density environments and the intragalactic medium within galaxy groups.
The evaluation and steering of English academy schools through inspection and examinations: national visions and local practices

The article analyses the redefinition and distribution of powers between central governance and local actors in English independent state-funded schooling. Earlier research on governance confirms the importance of the local and the school level in reshaping national-level reforms and steering policies. The research draws on data from interviews with national-level policymakers and an ethnographic school case study, thereby yielding contrasting views and perceptions of governance at the national level, and the day-to-day reality at the local level. The empirical analysis gives mixed results in that the national visions of innovative local practices seem not to be manifest at the local level. Despite the legal and financial freedoms granted to academy schools, the case academy is constrained by the national policy of steering by evaluation, namely inspection and testing, and the managerial practices of the sponsor. The article concludes that the real effect of academies is still under construction and meanwhile their space for action is strongly restricted by the tools of evaluation. As a more theoretical conclusion the analysis suggests that future analysis should concentrate more on action rather than structures and on evaluation as an embedded practice.
Atrial Electrical and Structural Changes Associated with Longstanding Hypertension in Humans: Implications for the Substrate for Atrial Fibrillation

Atrial Remodeling in Human Hypertension Introduction: Hypertension (HT) is the most common modifiable risk factor for atrial fibrillation (AF), yet little is known of the atrial effects of chronic HT in humans. We aimed to characterize the electrophysiologic (EP) and electroanatomic (EA) remodeling of the right atrium (RA) in patients with chronically treated systemic HT and left ventricular hypertrophy (LVH) without a history of AF.
Information "bridging" in a global organization

This paper describes an interview study investigating the collaborative information-seeking and sharing practices of a global software testing team. A site located in Europe was used as a temporal bridge to help in managing time zome differences between the US, China and India, All sites utilized this bridge for critical, synchronous information seeking. Interviews suggest that bridging can be a taxing job and that the success of the bridging arragement depended upon an intricate balance of temporal, infrastructure and cultural factors.
Dialoguing the Latina Experience in Higher Education

In this article, the authors discuss experiences and processes in their professional development as Latina academics. They frame their dialogue chronologically around the following themes: family background, graduate school, experiences with colleagues, participation in academia, interactions with students, and situations that inspire and motivate. By sharing their perspectives on issues linked to their status as women of color, the authors construct meaning and identify potential strategies for recruitment and success of minority students and academics.
Engaged universities, Community Based research Organizations and third Sector Science in a global System

Over the past three decades, since the civil rights era of the late 1960s and 70s, public science funding has shifted to support for military and industrial purposes and the health sciences. Most universities are now heavily subsidized through private sources, shifting the emphasis in research away from civic society engagement. Engaged scholarship and research conducted by, with and for communities are approaches that together have the potential to reinstate an emphasis on public scholarship that addresses structural inequities and social, health and cultural disparities. This paper argues that among various approaches to engaged social science, Action Research, endorsed by four generations of anthropologists in the United States, Canada and Latin America has the greatest potential to create knowledge that can be used to address social injustices at the local, national and international levels. Subsuming Action Research conducted by university centers, community based research organizations and other com.
Root Surface Caries Prevalence In Dakshina Kannada Population

Most epidemiological surveys of dental caries in adults have concentrated on assessing coronal carious lesions. Failure to assess and record the presence of root surface caries would understate the prevalence of caries in any population. [1] An increase in the pattern of the prevalence of root surface caries in a population is due to an increase in the age. This pattern is associated with people retaining the dentition for a longer period of time which has led to the teeth especially the root surfaces to get exposed either physiologically or pathologically. [2 – 14] Root surface caries a preventable disease is prevalent and debilitating among the adult population. [2] Various preventive methods employed which are population based may not be effective equally. [15, 16] Intensive root surface caries preventive measures which are office based are more effective in nature but accessibility to such measures may be impossible due to cost factors especially in the rural areas. There is an increased necessity to understand and identify the risk factors and high risk individuals to steer them towards root caries preventive measures. This study gives a description of the prevalence of root surface caries in the Dakshina Kannada, Karnataka, Indian population relating the experience to factors such as gender, age, diet, brushing habits, gingival recession, diabetes, tooth attacked and surface involved.
Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.

PURPOSE The CD20 antigen is expressed on more than 90% of B-cell lymphomas. It is appealing for targeted therapy, because it does not shed or modulate. A chimeric monoclonal antibody more effectively mediates host effector functions and is itself less immunogenic than are murine antibodies. PATIENTS AND METHODS This was a multiinstitutional trial of the chimeric anti-CD20 antibody, IDEC-C2B8. Patients with relapsed low grade or follicular lymphoma received an outpatient treatment course of IDEC-C2B8 375 mg/m2 intravenously weekly for four doses. RESULTS From 31 centers, 166 patients were entered. Of this intent-to-treat group, 48% responded. With a median follow-up duration of 11.8 months, the projected median time to progression for responders is 13.0 months. Serum antibody levels were sustained longer after the fourth infusion than after the first, and were higher in responders and in patients with lower tumor burden. The majority of adverse events occurred during the first infusion and were grade 1 or 2; fever and chills were the most common events. Only 12% of patients had grade 3 and 3% grade 4 toxicities. A human antichimeric antibody was detected in only one patient. CONCLUSION The response rate of 48% with IDEC-C2B8 is comparable to results with single-agent cytotoxic chemotherapy. Toxicity was mild. Attention needs to be paid to the rate of antibody infusion, with titration according to toxicity. Further investigation of this agent is warranted, including its use in conjunction with standard chemotherapy.
Towards proper name generation: a corpus analysis

We introduce a corpus for the study of proper name generation. The corpus consists of proper name references to people in webpages, extracted from the Wikilinks corpus. In our analyses, we aim to identify the different ways, in terms of length and form, in which a proper names are produced throughout a text.
PathSim

Similarity search is a primitive operation in database and Web search engines. With the advent of large-scale heterogeneous information networks that consist of multi-typed, interconnected objects, such as the bibliographic networks and social media networks, it is important to study similarity search in such networks. Intuitively, two objects are similar if they are linked by many paths in the network. However, most existing similarity measures are defined for homogeneous networks. Different semantic meanings behind paths are not taken into consideration. Thus they cannot be directly applied to heterogeneous networks. In this paper, we study similarity search that is defined among the same type of objects in heterogeneous networks. Moreover, by considering different linkage paths in a network, one could derive various similarity semantics. Therefore, we introduce the concept of meta path-based similarity, where a meta path is a path consisting of a sequence of relations defined between different object types (i.e., structural paths at the meta level). No matter whether a user would like to explicitly specify a path combination given sufficient domain knowledge, or choose the best path by experimental trials, or simply provide training examples to learn it, meta path forms a common base for a network-based similarity search engine. In particular, under the meta path framework we define a novel similarity measure called PathSim that is able to find peer objects in the network (e.g., find authors in the similar field and with similar reputation), which turns out to be more meaningful in many scenarios compared with random-walk based similarity measures. In order to support fast online query processing for PathSim queries, we develop an efficient solution that partially materializes short meta paths and then concatenates them online to compute top-k results. Experiments on real data sets demonstrate the effectiveness and efficiency of our proposed paradigm.
Absence of Gamma-Interferon-Inducible Lysosomal Thiol Reductase (GILT) Is Associated with Poor Disease-Free Survival in Breast Cancer Patients

Tumor immunosurveillance is known to be of critical importance in controlling tumorigenesis and progression in various cancers. The role of gamma-interferon-inducible lysosomal thiol reductase (GILT) in tumor immunosurveillance has recently been studied in several malignant diseases, but its role in breast cancer remains to be elucidated. In the present study, we found GILT as a significant different expressed gene by cDNA microarray analysis. To further determine the role of GILT in breast cancer, we examined GILT expression in breast cancers as well as noncancerous breast tissues by immunohistochemistry and real-time PCR, and assessed its association with clinicopathologic characteristics and patient outcome. The absence of GILT expression increased significantly from 2.02% (2/99) in noncancerous breast tissues to 15.6% (34/218) in breast cancer tissues (P<0.001). In accordance with its proliferation inhibiting function, GILT expression was inversely correlated with Ki67 index (P<0.05). In addition, absence of GILT was positively correlated with adverse characteristics of breast cancers, such as histological type, tumor size, lymph nodes status, and pTNM stage (P<0.05). Consistently, breast cancers with reduced GILT expression had poorer disease-free survival (P<0.005). Moreover, significantly decreased expression of GILT was found in both primary and metastatic breast cancer cells, in contrast to normal epithelial cells. These findings indicate that GILT may act as a tumor suppressor in breast cancer, in line with its previously suggested role in anti-tumor immunity. Thus, GILT has the potential to be a novel independent prognostic factor in breast cancer and further studies are needed to illustrate the underlying mechanism of this relationship.
Inhibition of the MAP3 kinase Tpl2 protects rodent and human -cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4 Elodie Varin, Anne Wojtusciszyn, Christophe Broca, Dany Muller, Magali Ravier, F Ceppo, Eric Renard, J-F Tanti, Stéphane Dalle
Victim-offender mediation in Canada

Four victim-offender mediation programs in Canada were evaluated. Victims and offenders who participated in mediation were significantly more likely to be satisfied than similar victims and offenders who were referred to mediation but did not participate. Victims of crime were less fearful of being revictimized by the offender after participating in a mediation than those victims in the comparison group. Broader use of this emerging area of social work practice in North America and Europe should be considered, along with more rigorous studies.
The nature of the schwa/zero alternation in French clitics: experimental and non-experimental evidence

This article examines the phonological status of schwa in clitics, in particular whether or not schwa should be included in their lexical representation. Several distributional and experimental arguments pointing to the lexical status of clitic schwas are reviewed and are shown to be inconclusive, due to the existence of additional data that suggest a different interpretation not involving underlying schwas. The discussion includes experimental results that fail to show residual lip rounding in the vicinity of an omitted schwa at clitic boundaries, contra Barnes and Kavitskaya's (2002) previous claim. In the absence of evidence to the contrary, the non-contrastive nature of clitic schwas militates against their underlying status.
Photosynthetic pigments estimate diet quality in forage and feces of elk (Cervus elaphus)

Understanding the nutritional dynamics of herbivores living in highly seasonal landscapes remains a central challenge in foraging ecology with few tools available for describing variation in selection for dormant versus growing vegetation. Here, we tested whether the concentrations of photosynthetic pigments (chlorophylls and carotenoids) in forage and feces of elk (Cervus elaphus L., 1785) were correlated with other commonly used indices of forage quality (digestibility, energy content, neutral detergent fiber (NDF), and nitrogen content) and diet quality (fecal nitrogen, fecal NDF, and botanical composition of the diet). Photosynthetic pigment concentrations were strongly correlated with nitrogen content, gross energy, digestibility, and NDF of elk forages, particularly in spring. Winter and spring variation in fecal pigments and fecal nitrogen was explained with nearly identical linear models estimating the effects of season, sex, and day-of-spring, although models of fecal pigments were consistently a.
Learning: The Experiences of Adults Who Work Full-Time While Attending Graduate School Part-Time

The experiences of students who are working full-time and going to graduate school part-time were the focus of this phenomenological investigation. Data analysis showed that these individuals, who reported high job involvement and strong career planning, were often stymied when they attempted to apply new ideas to the workplace. Those with strong social and family support reported feeling less stress than did those who did not, and preferred learning experiences in which they were active learners. Results from this exploratory study show that when individual characteristics, the academic environment, and the workplace environment are in alignment, individuals are most supported in becoming all they can be.
A novel endonuclease IV post-PCR genotyping system

Here we describe a novel endonuclease IV (Endo IV) based assay utilizing a substrate that mimics the abasic lesions that normally occur in double-stranded DNA. The three component substrate is characterized by single-stranded DNA target, an oligonucleotide probe, separated from a helper oligonucleotide by a one base gap. The oligonucleotide probe contains a non-fluorescent quencher at the 5′ end and fluorophore attached to the 3′ end through a special rigid linker. Fluorescence of the oligonucleotide probe is efficiently quenched by the interaction of terminal dye and quencher when not hybridized. Upon hybridization of the oligonucleotide probe and helper probe to their complementary target, the phosphodiester linkage between the rigid linker and the 3′ end of the probe is efficiently cleaved, generating a fluorescent signal. In this study, the use of the Endo IV assay as a post-PCR amplification detection system is demonstrated. High sensitivity and specificity are illustrated using single nucleotide polymorphism detection.
Urban Park Restoration and the "Museumification" of Nature

Ecological restoration is becoming an increasingly popular means of managing urban natural areas for human and environmental values. But although urban ecological restorations can foster unique, positive relationships between people and nature, the scope of these interactions is often restricted to particular activities and experiences, especially in city park settings. Drawing on personal experiences and research on urban park restorations in Chicago and San Francisco, I explore the phenomenon of this “museumification” in terms of its revision of landscape and land use history, how it presents nature through restoration design and implementation, and its potential impacts on the nature experiences of park users, particularly children. I conclude that although museum-type restorations might be necessary in some cases, alternative models for the management of urban natural areas may provide a better balance between goals of achieving authenticity in ecological restorations and authenticity of nature experiences.