Miracle-dz/UniFAR-FTUs huggingface dataset:
Pediatric penetrating thoracic trauma: A five-year experience

Penetrating thoracic trauma is managed nonoperatively in 85% of adult patients. We hypothesized that similar trauma in children would lead to proportionately more vital tissue damage and a higher rate of operative intervention. The pediatric penetrating thoracic trauma experience of a level one trauma center was analyzed over a five-year period. Data reviewed included circumstances of injury, Pediatric Trauma Score (PTS), interventions performed, and outcome. Of 61 children with thoracic trauma, 13 had penetrating injuries. Of these 13, seven were unintentional (five from firearms); the rest were caused by assaults. Seven patients (54%) underwent thoracotomy or laparotomy. All five patients with a PTS <8 underwent surgical intervention, whereas only two of the eight patients with a PTS >8 needed surgery (P <0.05). There was one death. We reached the following conclusions: 1) Children with penetrating thoracic trauma are more likely to require surgical intervention than adults. 2) Penetrating thoracic trauma in children should elicit a thorough search for operative lesions. 3) About half these injuries are unintentional, and thus potentially preventable.
[Epidemiological analysis of suicide in Brazil from 1980 to 2006].

OBJECTIVE The objective of this study was to carry out an epidemiological analysis of the suicide rates found in Brazilian regions and state capitals between 1980 and 2006. METHOD Data on mortality rates due to suicide were collected from the Departamento de Informática do Sistema Unico de Saúde (Information Technology Department of the Brazilian Public Health System--DATASUS). RESULTS A total of 158,952 suicide cases were registered between 1980 and 2006, excluding those cases in which the individual was less than 10 years old (n = 68). In the period under study, the total suicide rate in Brazil increased from 4.4 to 5.7 deaths per 100,000 inhabitants (29.5%). Higher average rates were found in the South (9.3) and Central-West (6.1) regions. Men were more likely to commit suicide. The highest suicide rates were found in the 70-years or above age range while the highest increases were found in the 20 to 59 year age bracket. The most dominant social-demographic characteristics of the persons who committed suicide in the period under study were low educational level and singlehood. The most common methods of suicide were hanging, fire arms and poisoning. CONCLUSION Although in Brazil the rate increased 29.5% in 26 years, the national rate is still considered to be low when compared to worldwide suicide rates (average of 4.9 per 100,000 inhabitants). Suicide rates in Brazilian regions vary broadly, ranging from 2.7 to 9.3.
Eliminating summer fallow reduces winter wheat yields, but not necessarily system profitability

Summer fallow is commonly used to stabilize winter wheat (Triticum aestivum L.) production in the Central Great Plains, but summer fallow results in soil degradation, limits farm productivity and profitability, and stores soil water inefficiently. The objectives of this study were to quantify the production and economic consequences of replacing summer fallow with spring-planted crops on the subsequent winter wheat crop. A summer fallow treatment and five spring crop treatments [spring canola (Brassica napus L.), oat (Avena sativa L.) + pea (Pisum sativum L.) for forage, proso millet (Panicum miliaceum L.), dry bean (Phaseolus vulgaris L.), and corn (Zea mays L.)] were no-till seeded into sunflower (Helianthus annuus L.) residue in a randomized complete block design with five replications during 1999, 2000, and 2001. Winter wheat was planted in the fall following the spring crops. Five N fertilizer treatments (0, 22, 45, 67, and 90 kg N ha -1 ) were randomly assigned to each previous spring crop treatment in a split-plot treatment arrangement. The 3-yr mean wheat grain yield after summer fallow was 29% greater than following oat + pea for forage and 86% greater than following corn. The 3-yr mean annualized net return for the spring crop and subsequent winter wheat crop was $4.20, -$6.91, -$7.55, -$29.66, -$81.17, and -$94.88 ha -1 for oat + pea for forage, proso millet, summer fallow, dry bean, corn, and spring canola, respectively. Systems involving oat + pea for forage and proso millet are economically competitive with systems using summer fallow.
A life changing experience - a rural perspective on living with physical disability

The topic of disability permeates medical literature. Yet, while disability as a medical condition is a focus of research and discussion, this research and discussion occurs often in neglectful ignorance of the total life experience of the individual person. This research is grounded in interpretive phenomenology. The philosophical grounding for the study draws on the works of Heidegger and Merleau-Ponty. The methodological structure of the research used van Manen’s (1990) hermeneutic phenomenology to guide a deeper understanding of the human experiences surrounding physical disability. Nine men and women living in different rural communities participated in a series of audiotaped, in-depth, unstructured interviews. The study suggests that living with disability encompasses a complex multidimensional phenomenon to be found within the context of a person’s life. Defined by physical and social barriers, living with disability denotes an interaction between impairment, activity limitation, and restricted participation. Four themes emerged that explicate the experience: (1) The Everyday Life of the Body; (2) Valuing a Rural Life; (3) Relationships in Life; and (4) Relating Time to Life. Disability was understood as a life-changing experience that entails complex time-consuming and energy-depleting processes and is defined by personal, family and social development. For the participants in this study, the lived experience of disability can be characterised by the expression: “life is not the same”. The understanding of the essential nature of this lived experience that emerged from this study has implications for health practice. The practice of disability intervention, based solely on impairment, may be inadequate to facilitate optimal health outcomes for rural people. Instead, physiotherapists can assist these people in discernment of priorities, maintaining existing relationships, advocation of rights, and finding the balance to encounter physical and societal adversity. Thus, the study suggests that health professionals need a broad conceptualisation of what constitutes legitimate knowledge for practice and a recognition that disability is an ongoing journey rather than a final destination.
Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress

Cells are often exposed to physical or chemical stresses that can damage the structures of essential biomolecules. Stress-induced cellular damage can become deleterious if not managed appropriately. Rapid and adaptive responses to stresses are therefore crucial for cell survival. In eukaryotic cells, different stresses trigger post-translational modification of proteins with the small ubiquitin-like modifier SUMO. However, the specific regulatory roles of sumoylation in each stress response are not well understood. Here, we examined the sumoylation events that occur in budding yeast after exposure to hyperosmotic stress. We discovered by proteomic and biochemical analyses that hyperosmotic stress incurs the rapid and transient sumoylation of Cyc8 and Tup1, which together form a conserved transcription corepressor complex that regulates hundreds of genes. Gene expression and cell biological analyses revealed that sumoylation of each protein directs distinct outcomes. In particular, we discovered that Cyc8 sumoylation prevents the persistence of hyperosmotic stress-induced Cyc8-Tup1 inclusions, which involves a glutamine-rich prion domain in Cyc8. We propose that sumoylation protects against persistent inclusion formation during hyperosmotic stress, allowing optimal transcriptional function of the Cyc8-Tup1 complex.
Optimisation of full-custom logic cells using response surface methodology

The authors demonstrate the significant advantages of response surface methodology for the optimisation of pass-transistor logic circuits with a large number of design variables. It is shown how the "curse of dimensionality" in this type of optimisation problem can be effectively dealt with by using methods from the set of techniques referred to as "design of experiments".
– induced photochemical internalisation of bleomycin in patients with solid malignancies : A first-inman phase I dose escalation clinical trial

1 Academic Unit of Oral and Maxillofacial Surgery, UCL Eastman Dental Institute, London, UK 2 UCL Department of Surgery, London, UK 3 Department of Radiation Biology, Oslo University Hospital, Oslo, Norway 4 PCI Biotech AS, Lysaker, Norway 5 Cancer Clinical Trials Unit, University College London Hospitals, London, UK 6 Head and Neck Unit, University College London Hospitals, London, UK 7 UCL Cancer Institute, London, UK
Parents' perceptions of their infants' participation in randomized controlled trials.

OBJECTIVE To explore parents' perceptions of their infants' participation in randomized control trials (RCTs) and the implications of the RCT for their infant and themselves. DESIGN A qualitative study using semistructured interviews. SETTING Participants were identified from neonatal intensive care unit (NICU) clinical registers and from responses to an advertisement put on the website of United Kingdom special care baby charity, BLISS. Interviews were conducted with parents face-to-face in their homes or over the telephone. PARTICIPANTS Sixteen parents of 12 infants born prematurely or with complications at full term and who had participated in one of three RCTs while receiving intensive care in one of seven NICUs. METHODS Interviews were audio-taped or digitally recorded, transcribed verbatim, and analyzed using systematic thematic analysis using WinMax qualitative software. RESULTS Five main themes emerged from the data. The themes were parents' immediate reactions to being approached about RCT enrollment, interactions between parents and clinicians upon the approach of enrollment and during the RCT, making the decision to enroll their infants, implications of the RCT for parents, and effects of the RCT on the infants. CONCLUSIONS Clinicians should be encouraged to approach parents about enrollment of their infants in clinical research given that parents reported mostly positive experiences related to this participation. However, appropriate measures should be taken to ensure that the individual needs of parents are being met throughout the entire research process from enrollment to follow-up.
Relations among Perceived Self-Efficacy, Self-Esteem, and School Achievement

The present research explored empirically the factorial dimensions of self-efficacy and self-esteem and associations among self-esteem, self-efficacy, and scholastic achievement as measured in 151 subjects (M age=13.4 yr.). Five factors emerged from factorial analysis: two factors reflected the self-esteem feelings (and were, respectively, named as self-referential self-esteem and comparative self-esteem). The remaining three factors reflected the self-efficacy beliefs in the three different scholastic domains considered, linguistic-literary, logical-mathematical, and technical-practical All self-efficacy scores were significantly correlated with scholastic achievement while no associations between self-esteem scores and scholastic performance were found. Nevertheless, self-efficacy and self-esteem dimensions shared some common aspects. In particular, each different self-esteem factor showed different magnitudes of association with domain-specific self-efficacy beliefs.
Arterial Hypertrophy in the Fetal and Neonatal Spontaneously Hypertensive Rat

Large artery dimensions in prenatal and postnatal nonnotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were evaluated to determine whether increased medial thickness is evident during early development. Microscopic cross-sections from perfuskm-fixed aortas and carotid arteries of fetal (22-day gestation) and neonatal (5 -day-old) animals were examined for numbers of laminae, luminal diameter and area, and medial thickness and area. SHR had a smaller mean body weight, and luminal diameters were the same in both strains. However, medial thickness and the numbers of laminae were significantly greater in SHR at both stages. Normalized ratios of medial thickness/luminal diameter and medial area/luminal area were also greater in SHR, indicating a disproportionate size of the arterial wall relative to the luminal space. Medial area/body weight ratios were also larger for SHR, suggesting the presence of greater medial mass per unit of body weight The data support the view that the increased mass of the hypertensive arterial system is established in SHR as early as the fetal stage.
Emotional distress as a key construct in the personal model of diabetes management : associations of fatigue, diabetes-specific distress, and depressive symptomatology with quality of life in type 2 diabetes mellitus.

EMOTIONAL DISTRESS AS A KEY CONSTRUCT IN THE PERSONAL MODEL OF DIABETES MANAGEMENT: ASSOCIATIONS OF FATIGUE, DIABETES-SPECIFIC DISTRESS, AND DEPRESSIVE SYMPTOMATOLOGY WITH QUALITY OF LIFE IN TYPE 2 DIABETES MELLITUS Chelsea L. Rothschild May 14,2010 The importance of maximizing self-management and quality of life is welldocumented in the diabetes literature. Although maintaining self-care is known to be important for individuals with type 2 diabetes, this is often difficult to maintain over time. Emotional distress has also been shown to impact self-care behaviors in adults with type 2 diabetes. Glasgow et al (1997) introduced a model of key variables influencing diabetes self-management. This study examined specific emotional Personal Model constructs of diabetes management. Independent and converging lines of research have implicated several potentially overlapping constructs that may reflect emotional distress in persons living with diabetes including: fatigue, distress, and global depression that is specific to the demands of diabetes. These emotional distress constructs have all been linked to self-management behavior and quality of life in chronic disease. This study sought to explain the associations between these emotional constructs and their impact on self-management and quality of life. Questionnaire and medical chart review data were collected from adults (N=151) with type 2 diabetes at an outpatient diabetes clinic. Depressive symptomatology, diabetes-specific distress, and fatigue were found to be
Terrestrial aftermath of the Moon-forming impact

Much of the Earth's mantle was melted in the Moon-forming impact. Gases that were not partially soluble in the melt, such as water and CO2, formed a thick, deep atmosphere surrounding the post-impact Earth. This atmosphere was opaque to thermal radiation, allowing heat to escape to space only at the runaway greenhouse threshold of approximately 100 W m−2. The duration of this runaway greenhouse stage was limited to approximately 10 Myr by the internal energy and tidal heating, ending with a partially crystalline uppermost mantle and a solid deep mantle. At this point, the crust was able to cool efficiently and solidified at the surface. After the condensation of the water ocean, approximately 100 bar of CO2 remained in the atmosphere, creating a solar-heated greenhouse, while the surface cooled to approximately 500 K. Almost all this CO2 had to be sequestered by subduction into the mantle by 3.8 Ga, when the geological record indicates the presence of life and hence a habitable environment. The deep CO2 sequestration into the mantle could be explained by a rapid subduction of the old oceanic crust, such that the top of the crust would remain cold and retain its CO2. Kinematically, these episodes would be required to have both fast subduction (and hence seafloor spreading) and old crust. Hadean oceanic crust that formed from hot mantle would have been thicker than modern crust, and therefore only old crust underlain by cool mantle lithosphere could subduct. Once subduction started, the basaltic crust would turn into dense eclogite, increasing the rate of subduction. The rapid subduction would stop when the young partially frozen crust from the rapidly spreading ridge entered the subduction zone.
Towards Extremely Scalable Nonlinear Domain Decomposition Methods for Elliptic Partial Differential Equation

The solution of nonlinear problems, e.g., in material science requires fast and highly scalable parallel solvers. FETI-DP (Finite Element Tearing and Interconnecting) domain decomposition methods are parallel solution methods for implicit problems discretized by finite elements. Recently, nonlinear versions of the well-known FETI-DP methods for linear problems have been introduced. In these methods, the nonlinear problem is decomposed before linearization. This approach can be viewed as a strategy to further localize computational work and to extend the parallel scalability of FETI-DP methods towards extreme-scale supercomputers. Here, a recent nonlinear FETI-DP method is combined with an approach that allows an inexact solution of the FETI-DP coarse problem. We combine the nonlinear FETI-DP domain decomposition method with an AMG (Algebraic Multigrid) method and thus obtain a hybrid nonlinear domain decomposition/multigrid method. We consider scalar nonlinear problems as well as nonlinear hyperelasticity problems in two and three space dimensions. For the first time weak parallel scalability can be shown for a FETI-DP domain decomposition method beyond 100 000 cores. We can show weak parallel scalability for up to 262 144 cores on the Mira BlueGene/Q supercomputer for our new implementation. Our analysis then reveals that scalability beyond 262 144 cores depends critically on, both, the efficient construction and solution of the coarse problem. Indeed, for the current implementation it was not expected that the construction of the coarse problem is a limiting factor.
Statistical analysis of survey-based event history data with application to modeling of unemployment duration

4 Tiivistelmä . 5 Sammanfattning . 7 List of original publications . 10
Developmental expression of maf-1 messenger ribonucleic acids in rat kidney by in situ hybridization histochemistry.

maf is a family of oncogenes, originally identified from the avian oncogenic retrovirus AS42, which encodes a nuclear bZip transcription factor protein. It has been reported that maf family genes have critical roles in embryological development and cellular differentiation. In this study, the distribution of maf-1 genes, the rat homologues of mafB, was examined in rat kidneys at the embryonic stages from 13 days, gestation (E13) through E21 and then 1, 2, 4, and 8 weeks after birth by in situ hybridization with (35)S-labeled antisense riboprobes. The cellular localization was determined using double in situ hybridization. Expression of maf-1 mRNA appeared weakly on E15 and was restricted to glomerular visceral epithelial cells during the pre- and postnatal stages until 2 weeks after birth and then gradually diminished. Double in situ hybridization demonstrated that maf-1 mRNA-positive cells in glomerulus also expressed Pod-1 gene, suggesting that maf-1 mRNA was expressed in the podocyte. These findings suggest that the expression of maf-1 gene may be involved in embryological development and/or differentiation of the kidney.
INFERENTIAL UNCERTAINTY IN DEEP NEURAL NETWORKS THROUGH SAMPLING

As deep neural networks (DNNs) are applied to increasingly challenging problems, they will need to be able to represent their own uncertainty. Modelling uncertainty is one of the key features of Bayesian methods. Bayesian DNNs that use dropout-based variational distributions and scale to complex tasks have recently been proposed. We evaluate Bayesian DNNs trained with Bernoulli or Gaussian multiplicative masking of either the units (dropout) or the weights (dropconnect). We compare these Bayesian DNNs ability to represent their uncertainty about their outputs through sampling during inference. We tested the calibration of these Bayesian fully connected and convolutional DNNs on two visual inference tasks (MNIST and CIFAR-10). By adding different levels of Gaussian noise to the test images in z-score space, we assessed how these DNNs represented their uncertainty about regions of input space not covered by the training set. These Bayesian DNNs represented their own uncertainty more accurately than traditional DNNs with a softmax output. We find that sampling of weights, whether Gaussian or Bernoulli, led to more accurate representation of uncertainty compared to sampling of units. However, sampling units using either Gaussian or Bernoulli dropout led to increased convolutional neural network (CNN) classification accuracy. Based on these findings we use both Bernoulli dropout and Gaussian dropconnect concurrently, which approximates the use of a spike-andslab variational distribution. We find that networks with spike-and-slab sampling combine the advantages of the other methods: they classify with high accuracy and robustly represent the uncertainty of their classifications for all tested architectures.
Ability of Massachusetts-type infectious bronchitis virus to increase colibacillosis susceptibility incommercial broilers: A comparison between vaccine and virulent field virus

The abilities of Massachusetts-type vaccine virus and virulent infectious bronchitis (IB) field virus to increase colibacillosis susceptibility were compared. In four experiments, 29-day-old female commercial broilers housed in isolators, were infected intratracheally and oculonasally with IB vaccine strains (HI20 and H52) or virulent IB field strains (D387 and M41) (4.8 or 6.8 log10 median embryo infective dose, per broiler). Five days later, Escherichia coli 506 strain was given intratracheally (5.6 to 8.8 log10 colony forming units/broiler). The incidence of nasal discharge at 3 and 5 days after IB virus infection was used to assess the clinical effect of the IB infection, while mortality, body weight uniformity and E. coli lesions at 7 days following E. coli inoculation were used as parameters for colibacillosis. Nasal discharge was observed in 61/117 (5%), 26/119 (22%), 35/119 (29%) and 115/120 (96%) of broilers infected with H120, H52, D387 and M41 virus, respectively. Apart from H52 and D387, differences between IBV strains were significant. IB vaccine and virulent IB viruses did not generally differ significantly in their ability to induce colibacillosis susceptibility. Mean colibacillosis lesion scores of H52-infected birds even significantly exceeded those of birds infected with the other IB viruses. The ability of H120 virus to induce colibacillosis susceptibility tended to be the weakest. The practical consequences of these findings are discussed.