Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute fluoxetine modulates emotional processing in young adult volunteers

Background Fluoxetine is generally regarded as the first-line pharmacological treatment for young people, as it is believed to show a more favourable benefit:risk ratio than other antidepressants. However, the mechanisms through which fluoxetine influences symptoms in youth have been little investigated. This study examined whether acute administration of fluoxetine in a sample of young healthy adults altered the processing of affective information, including positive, sad and anger cues. Method A total of 35 male and female volunteers aged between 18 and 21 years old were randomized to receive a single 20 mg dose of fluoxetine or placebo. At 6 h after administration, participants completed a facial expression recognition task, an emotion-potentiated startle task, an attentional dot-probe task and the Rapid Serial Visual Presentation. Subjective ratings of mood, anxiety and side effects were also taken pre- and post-fluoxetine/placebo administration. Results Relative to placebo-treated participants, participants receiving fluoxetine were less accurate at identifying anger and sadness and did not show the emotion-potentiated startle effect. There were no overall significant effects of fluoxetine on subjective ratings of mood. Conclusions Fluoxetine can modulate emotional processing after a single dose in young adults. This pattern of effects suggests a potential cognitive mechanism for the greater benefit:risk ratio of fluoxetine in adolescent patients.
Frequency of Val1016Ile mutation in the voltage‐gated sodium channel gene of Aedes aegypti Brazilian populations

One of the major insect pyrethroid resistance mechanisms affects its target site, the voltage‐gated sodium channel (Nav). In Aedes aegypti, the Val1016Ile substitution of the AaNav gene is associated to resistance in several Latin American countries. Genotyping of susceptible and resistant mosquitoes from seven Brazilian localities detected the 1016Ile mutation in five populations with a higher frequency of this substitution in resistant specimens in all cases. Furthermore, analysis of nine additional field populations revealed that five also presented the 1016Ile mutation. Our data suggest a recent dissemination and involvement of this substitution with pyrethroid resistance in Brazil.
Epstein–Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5

MicroRNAs (miRNAs) have been implicated in sequence-specific cleavage, translational repression or deadenylation of specific target mRNAs resulting in post-transcriptional gene silencing. Epstein–Barr virus (EBV) encodes 23 miRNAs of unknown function. Here we show that the EBV-encoded miRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. MiR-BART2 guides cleavage within the 3′-untranslated region (3′UTR) of BALF5 by virtue of its complete complementarity to its target. Induction of the lytic viral replication cycle results in a reduction of the level of miR-BART2 with a strong concomitant decrease of cleavage of the BALF5 3′UTR. Expression of miR-BART2 down-regulates the activity of a luciferase reporter gene containing the BALF5 3′UTR. Forced expression of miR-BART2 during lytic replication resulted in a 40–50% reduction of the level of BALF5 protein and a 20% reduction of the amount of virus released from EBV-infected cells. Our results are compatible with the notion that EBV-miR-BART2 inhibits transition from latent to lytic viral replication.
Cardio Vascular Diabetology Open Access Original Investigation Continuous Glucose Monitoring with Humalog Mix 25 versus Humalog Mix 50, Twice Daily: a Comparative Pilot Study -results from the Jikei-evaluation of Insulin Lispro Mixture on Pharmacodynamics and Glycemic Variance (j-evolve) Study

Objective: To evaluate glycemic variability associated with two different premixed insulin analogue formulations when used in a twice-daily regimen. Patients and Methods: Subjects comprised type 2 diabetic patients aged 20-79 years, treated with twice daily premixed insulin or insulin analogue formulations. All subjects were hospitalized for 6 days and randomized to receive either Humalog Mix 25 (Mix 25) or Humalog Mix 50 (Mix 50). They were then crossed over to the other arm between day 3 and day 4 of the study. Continuous glucose monitoring (CGM) was performed on all subjects to examine the differences in glycemic variability. Results: Eleven type 2 diabetic patients were enrolled. No significant difference was found in 24-hour mean glucose values and their SDs, pre-meal glucose values, increases from pre-meal to peak glucose values, or time to peak glucose levels between either group. However, the mean glucose values observed during 0-8 hrs were significantly lower with Mix 25 compared to Mix 50 (128 vs. 147 mg/dL; p = 0.024). Conclusions: The twice-daily Mix 25 regimen provided superior overnight glycemic control compared to the Mix 50 regimen in Japanese patients with type 2 diabetes. However, both twice-daily regimens with either Mix 25 or Mix 50 provided inadequate post-lunch glycemic control. Introduction Results from the Diabetes Control Complications Trial (DCCT) [1] and the Kumamoto Study [2] demonstrated that in both type 1 and type 2 diabetes, intensive insulin therapy combining regular-and intermediate-acting insulin formulations, provides a significantly greater improvement in HbA1c values and reduces the onset and progression of diabetes-associated microangiopathy to a
A Physics-Based Statistical RTN Model for the Low Frequency Noise in MOSFETs

In this paper, we develop a statistical model for random telegraph noise (RTN) related low-frequency noise (LFN). With our proposed model, one can calculate the expected value and the variability of the noise as a function of bias and device parameters. We clarify why the variability of RTN/LFN does not follow a 1/√area dependence. The model explains the effect of the halo implanted regions on the LFN statistics and the large variability of long channel devices found under certain bias conditions, which can be as large as that of short channel devices. We show that the LFN of n-channel and p-channel MOSFETs can be described by the same mechanism. From our results, we derive that the trap density of the p-channel device is a strongly varying function of the Fermi level, whereas for the n-channel the trap density can be considered constant. We validate the model through numerous experimental results from different CMOS nodes, down to 40 nm. We also demonstrate that the noise, and its variability, found in our measurements can be modeled using reasonable physical quantities.
Haptic Perception with a Robotic Hand

We have developed an 8 d.o. f. robot hand which has been tested with three computational models of haptic perception. Two of the models are based on the tensor p roduct of different proprioceptive and sensory signals and a self-organizing map (SOM), and one use s a novel self-organizing neural network, the T-MPSOM. The computational models have been trained and tested with a set of objects consisting of hard spheres, blocks and cylinders. The first computation l model, which is based on the tensor product, was able to discriminate between all the test objec ts. The second and third models could also discriminate between the test objects, but in addition they w re capable of shape categorization.
A jeu de taquin theory for increasing tableaux, with applications to K-theoretic Schubert calculus

We introduce a theory of jeu de taquin for increasing tableaux, extending fundamental work of Schutzenberger (1977) for standard Young tableaux. We apply this to give a new combinatorial rule for the K-theory Schubert calculus of Grassmannians via K-theoretic jeu de taquin, providing an alternative to the rules of Buch and others. This rule naturally generalizes to give a conjectural root-system uniform rule for any minuscule flag variety G/P, extending recent work of Thomas and Yong. We also present analogues of results of Fomin, Haiman, Schensted and Schutzenberger.
A new relaying scheme for cheap wireless relay nodes

Wireless networks consist of senders, receivers, and intermediate nodes collaborating (more or less) to establish the communication paths. Most of the researches in the domain of wireless network have focused on routing based approaches. In such an approach, wireless network is reduced to a dynamic graph, and a minimum cost routing mechanism is applied. These approaches have led to several routing mechanisms as OLSR and AODV. However, the fundamental nature of wireless network is the broadcast. In the wireless network, all the tuned receivers potentially receive every transmission. This basic property is not well captured by graph-based approaches where packets follow a single path from sender to receiver. In this paper we propose a relaying scheme for wireless multi-hop networks. It is based on collaboration of intermediate relays at network layer to forward useful side information in place of forwarding packets. In our scheme we assume that the nodes are not able to benefit from any interference cancellation mechanism. The channels from sender to relay nodes and from sender to receiver are logically separated through a temporal scheduling. This model is realistic for many practical scenarios in the context of wireless networks. We show in this paper the information theoretic bounds and show that they are achievable using practical codes. The proposed coding scheme is simulated in realistic scenarios. The obtained results show a remarkable improvement in throughput, relay load and reliability compared to network using classical routing approach.
Electrical Characterization of Some Native Insulators on Germanium

Preliminary characterization of two native insulators on germanium is reported. A technique for preparing oxide by a room temperature chemical technique (wet chemical oxidation) is described. Compositional data based on IR transmission and ellipsometry, as well as characteristics of MOS capacitors based on this film are given. Also, compositional and electrical characterization of nitrided atmospheric pressure oxides are reported here. These films have very low fixed charge and interface state densities, and show excellent potential for use as gate insulators in a germanium MOS technology.
Chandelier and Interfascicular Neurons in the Adult Mouse Piriform Cortex

The structure of two neuron types native to the adult mouse piriform cortex (PC) is described. The first cell, termed an interfascicular neuron (IFN), lies between the axon fascicles of layer I. The IFN axon divides dichotomously and daughter fibrils run horizontally in the domain of layer Ia. The frequent apposition of the IFN axon to distal dendrites of the underlying pyramidal cells suggests an en passage synaptic interaction with them. A second neuron observed in layer II, or less frequently in layer III, matched in most respects the structure of the chandelier cell (CC) described elsewhere in the neo- and archi-cortex. In the PC, chandelier cells (PC-CC) display the following peculiarities. First, the PC-CC axonal field distributes in the neuropil of layers II and III and candlesticks are in close apposition to the initial axonal segment of the pyramidal cell, although somatic interactions cannot be rule out. Second, the PC-CC ascending dendrites pierce layer I, receiving short collaterals and boutons en passage from the olfactory axons therein. The possible role of IFN's and PC-CC and their interactions with the adjacent cells is discussed in the broad context of the cellular organization of the PC.
Laparoscopic vs. small incision cholecystectomy: Implications for pulmonary function and pain. A randomized clinical trial

Background: Upper abdominal surgery, including laparoscopic cholecystectomy (LC), is associated with post‐operative pulmonary dysfunction. LC has, by consensus, become the treatment of choice for symptomatic cholecystolithiasis. The small‐incision cholecystectomy (SIC), a procedure which does not require a pneumoperitoneum threatens to be lost to clinical practice even though there is evidence of equality. We hypothesized that the SIC technique should be equal and might even be superior to the LC when considering post‐operative pulmonary function due to the short incision length.
Long-Term Results after Treatment of Basal Cell Carcinoma of the Eyelid in Southwestern Finland

Purpose Basal cell carcinoma (BCC) is the most common skin cancer of the eyelid, showing an increasing incidence in the white population. The authors studied the clinical characteristics and the treatment results of BCC of the eyelid in southwestern Finland during 1977–1997. Methods The authors reviewed the case records of 191 patients with BCC of the eyelids treated at the Turku University Eye Clinic during 1977–1997. The mean follow-up period after the treatment was 8.6±5.2 years. Results The 191 patients had altogether 194 BCC tumors of the eyelid with the mean diameter of the tumor being smaller than 10 mm in 77.3% of cases. Of the 194 BCC tumors of the eyelid 16.0% showed recurrence, and the recurrence rate of all surgically treated tumors was 13.7%. In this study 61 patients (31.9%) developed other malignancies than the BCC of the eyelid including 28 patients (14.7 %) with carcinoma in other locations than skin. Conclusions Incompletely removed BCCs of the eyelid showed only 18.9% recurrence rate during the follow-up time. On the other hand, BCCs of the eyelid should not be underestimated because of the rather high total recurrence rate. The frequency of 31.9% of other malignancies than BCC of the eyelid is remarkably high and requires special attention from the ophthalmologist taking care of the patient with BCC of the eyelid.
Open Energy Market Strategies in Microgrids: A Stackelberg Game Approach Based on a Hybrid Multiobjective Evolutionary Algorithm

The emergence of microsources holds promise to reduce the carbon emissions and exploit more renewables in order to meet the worldwide growing electrical energy demands. However, there exist several challenges, such as optimizing the tradeoff between the use of renewable and nonrenewable energy sources, to leverage affordable electric power while minimizing carbon emissions. Game theoretic approaches have been widely used in various scientific domains and have recently also increasingly been used in smart grids, whereby evolutionary paradigms have been widely deployed as a popular heuristic search method to solve and optimize complex real-life scientific problems. A promising approach is the development of such evolutionary algorithms and game theoretic approaches in the context of open energy markets. In this paper, we develop an analytic model of a multileader and multifollower Stackelberg game approach and propose a bi-level hybrid multiobjective evolutionary algorithm to find optimal strategies that maximize the profit of utilities, and minimize carbon emissions in an open energy market among interconnected microsources.
Phase II study of bryostatin 1 and vincristine for aggressive non‐Hodgkin lymphoma relapsing after an autologous stem cell transplant

Bryostatin 1, isolated from a marine bryozoan, enhances the efficacy of cytotoxic agents through modulation of the protein kinase C pathway and is active in combination with vincristine for diffuse large B‐cell lymphoma. Further, the apoptotic frequency of peripheral blood T lymphocytes as determined by flow cytometry may predict which patients will respond to this combination. We tested the efficacy and safety of bryostatin 1 50 μg/m2 given over 24 hr and vincristine 1.4 mg/m2 on days 1 and 15 every 28 days in aggressive B‐cell non‐Hodgkin lymphoma (NHL) relapsing after autologous stem cell transplantation. End points included tumor response, toxicity, and survival. Responses were correlated with an increase in apoptotic frequency of CD5+ cells by flow cytometry using annexin V staining. Fourteen patients were enrolled with 13 being evaluable for a response. The overall response rate was 31% with two patients achieving a complete response. The most common toxicities were Grade 3 lymphopenia (seven patients), Grade 3 to 4 neutropenia (two patients), and Grade 3 hypophosphatemia (two patients). Median progression‐free and overall survivals for all patients were 5.7 and 21.4 months, respectively. One patient demonstrated an increase in T‐cell apoptotic frequency, also achieving a complete response. Bryostatin 1 and vincristine have efficacy in select patients with aggressive NHL. Future investigations of agents targeting the protein kinase C pathway may benefit from early response assessment using flow cytometry to evaluate T‐cell apoptosis. Am. J. Hematol. , 2009. © 2009 Wiley‐Liss, Inc.
Angiogenesis factor pattern differs in acute lymphoblastic leukemia and chronic lymphocytic leukemia

Abstract Angiogenesis is an important event in the survival and progression of solid tumors. The angiogenic status and the exact role of the angiogenic cytokines in lymphoid leukemia has not been fully elucidated. We have investigated the profile of the systemic components of angiogenic regulation in B-lineage acute lymphoblastic leukemia (B-ALL) and B-chronic lymphocytic leukemia (B-CLL), namely vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-α), endostatin and matrix metalloproteinase-9 (MMP-9) using enzyme-linked immunosorbent assay (ELISA). In B-ALL patients, sVEGF, and MMP-9 were significantly lower than control levels at diagnosis (p < 0.001) and increased to near control levels in remission (p > 0.05). Both serum TNF-α and endostatin levels showed no significant difference at diagnosis (p > 0.05) and in remission (p > 0.05) compared to control levels. VEGF, TNF-α, MMP-9 and endostatin levels were not significantly correlated with peripheral white cell count or bone marrow blast cell count, but were positively correlated with platelet count. In B-CLL patients, serum VEGF, MMP-9 and TNF-α were significantly higher (p < 0.001 = 0.009, 0.007, respectively) and decreased to near control levels in remission (p > 0.05 for all). Serum endostatin levels showed no significant difference at diagnosis and in remission compared to control levels (p > 0.05). A significant positive correlation between VEGF, TNF-α, MMP-9 and peripheral white cell counts, bone marrow lymphocytic count and platelets count were found. In conclusion, our data suggest that the driving forces of angiogenic factors (VEGF, TNF-α and MMP-9) in adult B-ALL appears different from that in B-CLL patients.
Overview of the Author Identification Task at PAN-2017: Style Breach Detection and Author Clustering

Several authorship analysis tasks require the decomposition of a multi-authored text into its authorial components. In this regard two basic prerequisites need to be addressed: (1) style breach detection, i.e., the segmenting of a text into stylistically homogeneous parts, and (2) author clustering, i.e., the grouping of paragraph-length texts by authorship. In the current edition of PAN we focus on these two unsupervised authorship analysis tasks and provide both benchmark data and an evaluation framework to compare different approaches. We received three submissions for the style breach detection task and six submissions for the author clustering task; we analyze the submissions with different baselines while highlighting their strengths and weaknesses.
Entanglement-assisted capacity of a quantum channel and the reverse Shannon theorem

The entanglement-assisted classical capacity of a noisy quantum channel (C/sub E/) is the amount of information per channel use that can be sent over the channel in the limit of many uses of the channel, assuming that the sender and receiver have access to the resource of shared quantum entanglement, which may be used up by the communication protocol. We show that the capacity C/sub E/ is given by an expression parallel to that for the capacity of a purely classical channel: i.e., the maximum, over channel inputs /spl rho/, of the entropy of the channel input plus the entropy of the channel output minus their joint entropy, the latter being defined as the entropy of an entangled purification of /spl rho/ after half of it has passed through the channel. We calculate entanglement-assisted capacities for two interesting quantum channels, the qubit amplitude damping channel and the bosonic channel with amplification/attenuation and Gaussian noise. We discuss how many independent parameters are required to completely characterize the asymptotic behavior of a general quantum channel, alone or in the presence of ancillary resources such as prior entanglement. In the classical analog of entanglement-assisted communication - communication over a discrete memoryless channel (DMC) between parties who share prior random information - we show that one parameter is sufficient, i.e., that in the presence of prior shared random information, all DMCs of equal capacity can simulate one another with unit asymptotic efficiency.
What does expert opinion in guidelines mean? a meta-epidemiological study

Guidelines often use the term expert opinion (EO) to qualify recommendations. We sought to identify the rationale and evidence type in EO recommendations. We searched multiple databases and websites for contemporary guidelines published in the last decade that used the term EO. We identified 1106 references, of which 69 guidelines were included (2390 recommendations, of which 907 were qualified as EO). A rationale for using EO designation was not provided in most (91%) recommendations. The most commonly cited evidence type was extrapolated from studies that did not answer guideline question (40% from randomised trials, 38% from observational studies and 2% from case reports or series). Evidence extrapolated from populations that were different from those addressed in the guideline was found in 2.5% of EO recommendations. We judged 5.6% of EO recommendations as ones that could have been potentially labelled as good practice statements. None of the EO recommendations were explicitly described as being solely dependent on the clinical experience of the panel. The use of EO as a level of evidence in guidelines remains common. A rationale for such use is not explicitly provided in most instances. Most of the time, evidence labelled as EO was indirect evidence and occasionally was very low-quality evidence derived from case series. We posit that the explicit description of evidence type, as opposed to using the label EO, may add clarity and transparency and may ultimately improve uptake of recommendations.
Structural studies of tri-functional human GART

Human purine de novo synthesis pathway contains several multi-functional enzymes, one of which, tri-functional GART, contains three enzymatic activities in a single polypeptide chain. We have solved structures of two domains bearing separate catalytic functions: glycinamide ribonucleotide synthetase and aminoimidazole ribonucleotide synthetase. Structures are compared with those of homologous enzymes from prokaryotes and analyzed in terms of the catalytic mechanism. We also report small angle X-ray scattering models for the full-length protein. These models are consistent with the enzyme forming a dimer through the middle domain. The protein has an approximate seesaw geometry where terminal enzyme units display high mobility owing to flexible linker segments. This resilient seesaw shape may facilitate internal substrate/product transfer or forwarding to other enzymes in the pathway.