Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of the DSM–5 Alternative Model Personality Disorder Diagnoses in Turkey, Part 1: LEAD Validity and Reliability of the Personality Functioning Ratings

ABSTRACT This study addresses longitudinal, expert, all data (LEAD) validity and reliability of the personality functioning ratings in Turkey, which are essential in assessing Criterion A for the entire DSM–5 alternative model for personality disorders (AMPD) diagnoses. A total of 120 consenting patients recruited at a university psychiatry clinic were rated by individual clinicians with respect to DSM–III–R and AMPD criteria. Subsequently, a LEAD panel consisting of 3 senior clinicians convened to reach a consensus personality disorder diagnosis for each participant. Blind personality functioning ratings of a subgroup of 20 participants by the same set of 4 clinicians were obtained for test–retest reliability investigation. Concordance between the LEAD and AMPD diagnoses was as good as that between the LEAD and DSM–III–R diagnoses (kappas = .68). The personality functioning scores correlated strongly (r > .50) with the sum of specific DSM–III–R diagnoses. Reliability estimates pertaining to the personality functioning scores and resultant AMPD Criterion A decisions were mostly in the good range. In conclusion, DSM–5 alternative model-oriented personality functioning ratings yield total or composite scores that are evidently valid and reliable tools to diagnose general personality disorder and to estimate its global severity.
Analysis of early death in newly diagnosed acute promyelocytic leukemia patients

Abstract The aim of this study was to identify risk factors for early death (ED) in acute promyelocitic leukemia (APL) patients. Clinical records of 49 APL patients who suffered ED were divided into 4 groups: death before treatment or within the first 3 days (immediate death; iED group), death during treatment at least 3 days after commencement (ED after treatment), low/intermediate risk, and high-risk groups. White blood cell (WBC) count, high-risk cases, prothrombin time (PT) prolongation, international society on thrombosis and hemostasis (ISTH) scores (P < .05), bleeding (P = .05), and death due to severe hemorrhage (P = .010) were higher in iED group than ED after treatment. And the time from onset to initial hospitalization or death was significantly shorter (P < .05) in iED patients. LDH level (P = .002), PT prolongation (P = .014), and incidence of grades 3 or 4 bleeding (P = .049) were higher in high-risk group than in ED and low/intermediate-risk groups, while the times from onset to the initial hospitalization or death were lower for ED patients in high-risk group (P = .037). We found that different types of EDs have different clinical features. A high WBC count contributes to the occurrence of more ED, which is usually not associated with delay of diagnosis and hospitalization. Current therapeutic strategies to reduce the incidence of ED in these cases are not adequate and will benefit from focused research attention.
Fenofibrate prevents skeletal muscle loss in mice with lung cancer

Significance The cancer anorexia cachexia syndrome (CACS) is a condition characterized by skeletal muscle degradation with no effective treatment. CACS is particularly prevalent in patients with nonsmall cell lung cancer, where it reduces quality of life and increases mortality. Using an inducible lung cancer model, we characterize the changes in intermediary metabolism that occur during CACS in mice. We identify a unique serum metabolite profile consisting of low ketones and increased glucocorticoid levels. Hypoketonemia is associated with reduced expression of hepatic peroxisome proliferator-activated receptor-α (PPARα) targets that regulate fatty acid oxidation and ketogenesis. Replacing ketone production using the PPARα agonist, fenofibrate, reduced glucocorticoid levels, prevented skeletal muscle wasting, and minimized weight loss. These exciting results provide important preclinical data toward a therapeutic strategy. The cancer anorexia cachexia syndrome is a systemic metabolic disorder characterized by the catabolism of stored nutrients in skeletal muscle and adipose tissue that is particularly prevalent in nonsmall cell lung cancer (NSCLC). Loss of skeletal muscle results in functional impairments and increased mortality. The aim of the present study was to characterize the changes in systemic metabolism in a genetically engineered mouse model of NSCLC. We show that a portion of these animals develop loss of skeletal muscle, loss of adipose tissue, and increased inflammatory markers mirroring the human cachexia syndrome. Using noncachexic and fasted animals as controls, we report a unique cachexia metabolite phenotype that includes the loss of peroxisome proliferator-activated receptor-α (PPARα) -dependent ketone production by the liver. In this setting, glucocorticoid levels rise and correlate with skeletal muscle degradation and hepatic markers of gluconeogenesis. Restoring ketone production using the PPARα agonist, fenofibrate, prevents the loss of skeletal muscle mass and body weight. These results demonstrate how targeting hepatic metabolism can prevent muscle wasting in lung cancer, and provide evidence for a therapeutic strategy.
The Abrogation of Phosphorylation Plays a Relevant Role in the CCR5 Signalosome Formation with Natural Antibodies to CCR5

The exposure to CCR5 (CC chemokine receptor 5) specific natural antibodies in vitro produces a Class B β-arrestin2-dependent CCR5 retention with the aid of ERK1, due to the formation of a CCR5 signalosome, which remains stable for at least 48 h. Considering that β-arrestins and MAPKs are receptive to environmental signals, their signal complexes could be one of the key junction for GPCRs internalization related signal transduction. Here, we demonstrate that, in T cells, the phosphorylation status of either CCR5 receptor or ERK1 protein is necessary to drive the internalized receptor into the early endosomes, forming the CCR5 signalosome. In particular, our data show that β-arrestin2/ERK1 complex is a relevant transducer in the CCR5 signaling pathway. Understanding the mechanism of CCR5 regulation is essential for many inflammatory disorders, tumorigenesis and viral infection such as HIV.
A Voltage Driven Traveling-Wave Model for the Simulation of an Integrated Three-Section MOPA Under Static and Modulated Operation

We present a voltage driven traveling-wave model for the simulation of an integrated three-section master oscillator power amplifier. The model considers the applied voltage to each active section as an input parameter and calculates the longitudinal profiles of the local current and carrier densities. The model reproduces the experimental evidence of either a positive current when the section is acting as an amplifier or a negative current when it is acting as a photodiode in the photovoltaic mode. We validate the model by comparing with experimental results obtained both, under static operation for a variety of biasing conditions and under direct modulation.
Psychological and psychosocial interventions for negative symptoms in psychosis: Systematic review and meta-analysis

Background Negative symptoms observed in patients with psychotic disorders undermine quality of life and functioning. Antipsychotic medications have a limited impact. Psychological and psychosocial interventions, with medication, are recommended. However, evidence for the effectiveness of specific non-biological interventions warrants detailed examination. Aims To conduct a meta-analytic and systematic review of the literature on the effectiveness of non-biological treatments for negative symptoms in psychotic disorders. Method We searched for randomised controlled studies of psychological and psychosocial interventions in psychotic disorders that reported outcome on negative symptoms. Standardised mean differences (SMDs) in values of negative symptoms at the end of treatment were calculated across study domains as the main outcome measure. Results A total of 95 studies met our criteria and 72 had complete quantitative data. Compared with treatment as usual cognitive–behavioural therapy (pooled SMD −0.34, 95% CI −0.55 to −0.12), skills-based training (pooled SMD −0.44, 95% CI −0.77 to −0.10), exercise (pooled SMD −0.36, 95% CI −0.71 to −0.01), and music treatments (pooled SMD −0.58, 95% CI −0.82 to −0.33) provide significant benefit. Integrated treatment models are effective for early psychosis (SMD −0.38, 95% CI −0.53 to −0.22) as long as the patients remain in treatment. Overall quality of evidence was moderate with a high level of heterogeneity. Conclusions Specific psychological and psychosocial interventions have utility in ameliorating negative symptoms in psychosis and should be included in the treatment of negative symptoms. However, more effective treatments for negative symptoms need to be developed.
An Analysis of the Microstructure and Mechanical Properties of Rapidly Solidified Al-1Fe-1Ni-5Mg Alloy

Experiments on Al-1Fe-1Ni-5Mg alloy were performed to determine the effect of rapid solidification (RS) on the material strengthening, which result from the refining of the grain size and intermetallic compounds. Additionally, an enhancement of the material strengthening due to magnesium addition was also observed. RS procedure was performed using spray deposition of the molten alloy on the rotating water-cooled copper roll. As a result, highly refined structure of rapidly solidified flakes was obtained. Using common powder metallurgy (PM) techniques, i.e. cold pressing, vacuum degassing and hot extrusion, as received RS-flakes were consolidated to the bulk PM materials. For comparison purposes, the conventionally cast and hot extruded Al-1Fe-1Ni-5Mg alloy was studied as well. RS process combined with hot pressing and extrusion procedure was found to be very effective method for the manufacture of fine grained material and effective refinement of intermetallic compounds. However some inhomogenity of particles distribution was observed, which was ascribed to varied cooling rate dependent on the particular spray-drop size. Mechanical properties of as-extruded material were examined using compression test at 293K – 873K. High strength and ductility of as-extruded RS material with respect to conventionally produced alloy were observed. However, the effect of enhanced mechanical properties of RS material is observed only at low deformation temperatures. It was found that increasing deformation temperature above 400K results in negligible hardening of RS samples if compared to conventionally produced material.
Watson for Oncology and breast cancer treatment recommendations: agreement with an expert multidisciplinary tumor board

Background Breast cancer oncologists are challenged to personalize care with rapidly changing scientific evidence, drug approvals, and treatment guidelines. Artificial intelligence (AI) clinical decision-support systems (CDSSs) have the potential to help address this challenge. We report here the results of examining the level of agreement (concordance) between treatment recommendations made by the AI CDSS Watson for Oncology (WFO) and a multidisciplinary tumor board for breast cancer. Patients and methods Treatment recommendations were provided for 638 breast cancers between 2014 and 2016 at the Manipal Comprehensive Cancer Center, Bengaluru, India. WFO provided treatment recommendations for the identical cases in 2016. A blinded second review was carried out by the center's tumor board in 2016 for all cases in which there was not agreement, to account for treatments and guidelines not available before 2016. Treatment recommendations were considered concordant if the tumor board recommendations were designated 'recommended' or 'for consideration' by WFO. Results Treatment concordance between WFO and the multidisciplinary tumor board occurred in 93% of breast cancer cases. Subgroup analysis found that patients with stage I or IV disease were less likely to be concordant than patients with stage II or III disease. Increasing age was found to have a major impact on concordance. Concordance declined significantly (P ≤ 0.02; P < 0.001) in all age groups compared with patients <45 years of age, except for the age group 55-64 years. Receptor status was not found to affect concordance. Conclusion Treatment recommendations made by WFO and the tumor board were highly concordant for breast cancer cases examined. Breast cancer stage and patient age had significant influence on concordance, while receptor status alone did not. This study demonstrates that the AI clinical decision-support system WFO may be a helpful tool for breast cancer treatment decision making, especially at centers where expert breast cancer resources are limited.
Current and prospective sights in mechanism of deoxynivalenol‐induced emesis for future scientific study and clinical treatment

Deoxynivalenol (DON), one of trichothecene mycotoxins produced by the fungus Fusarium, is commonly detected in cereal foods and in secondary food production across the world. Lower concentrations of DON induce a dose‐related feed refusal (anorexia), whereas it acts as a potent emetic agent at higher levels. DON‐induced emesis in humans and livestock can be observed and recorded in both undeveloped and developed regions such as Lixian, Guide and Huangzhong in China and Illinois in the USA. Some studies with different animal models (pigs and minks) suggested that DON could change expressions of 5‐hydroxytryptamine, peptide YY, neuropeptide Y2 receptor and nucleobindin‐2/nesfatin‐1 in plasma and different areas of the brain. Some selective antagonist of 5‐hydroxytryptamine 3 receptors can inhibit DON‐induced emetic response. Otherwise, the Ca2+ homeostasis and MAPK pathway could be potential directions in future studies. Dolasetron, dantrolene and JNJ‐31020028 can be used in clinical treatment but they have potential toxic effects. (−)Epicatechin, ginger phytochemicals and isoflavone can be tested in in vitro and in vivo for their usage as food additives for reducing the emesis. The present review summarizes and discusses some information from previous and recent prominent publications with the aim to provide some comprehensive and helpful data for understanding the mechanism of DON‐induced emesis. Copyright © 2017 John Wiley & Sons, Ltd.
Growth of gas bubbles in the foam extrusion process

In comparison to other kinds of crosslinked thermoset foam, recyclable polyolefin foam is an environmentally friendly material, but it increases the degree of foaming in the foam extrusion process. In order to overcome this shortcoming, the effect of material and process variables on the degree of foaming and the growth behavior of the gas bubbles was studied by using polyolefins, such as polypropylene (PP), low density polyethylene (LDPE), and high density polyethylene (HDPE). These materials were foamed in extrusion process with a blowing agent consisting of sodium bicarbonate and citric acid. A higher degree of foaming was obtained with a low temperature of cooling water and high melt temperature. The take-up speed did not influence the degree of foaming. It was also observed from cell morphologies that the size of the gas bubbles was reduced with increased take-up speed and decreased melt temperature, but the size of the gas bubbles was nearly invariant as the temperature of the cooling water increased. In addition, the effects of the molecular weight, the molecular structure, the melt viscosity, and the melt tension on the degree of foaming and the growth of the gas bubbles were investigated. It was revealed that the degree of foaming and the size of the gas bubbles were directly related to the melt tension of the polymer melt, regardless of the structure and the molecular weight of the polymer resin and the temperature of the polymer melt. This implies that the ability to sustain the cell in the melt state is a critical foaming parameter in the extrusion process. © 2000 John Wiley & Sons, Inc. Adv Polym Techn 19: 97–112, 2000
Phonological similarity effects in Cantonese word recognition

Two lexical decision experiments in Cantonese are described in which the recognition of spoken target words as a function of phonological similarity to a preceding prime is investigated. Phonological similarity in first syllables produced inhibition, while similarity in second syllables led to facilitation. Differences between syllables in tonal and segmental structure had generally similar effects.
Early Functional Outcomes of Periacetabular Osteotomy After Failed Hip Arthroscopic Surgery for Symptomatic Acetabular Dysplasia

Background: Persistent acetabular dysplasia is a common reason for the failure of hip arthroscopic surgery; however, the effect of prior hip arthroscopic surgery on functional outcomes after subsequent periacetabular osteotomy (PAO) is unknown. Hypothesis/Purpose: The purpose of this study was to (1) compare demographic and radiological findings in patients who had and had not undergone previous hip arthroscopic surgery before PAO for symptomatic acetabular dysplasia and (2) compare the short-term, hip-specific patient-reported outcomes in these same patient populations. It was hypothesized that prior hip arthroscopic surgery is associated with worse early functional outcomes in PAO. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective cohort study design was utilized. Patients undergoing PAO were enrolled from a single-center, prospective hip preservation registry from March 2011 to April 2015. Patients with a minimum of 1-year clinical follow-up with preoperative and postoperative outcome scores undergoing PAO were eligible for inclusion (n = 93 patients; mean clinical follow-up, 24 months [range, 11-58 months]). The study group consisted of patients undergoing PAO for symptomatic hip dysplasia after prior hip arthroscopic surgery (PREVSCOPE group; 22 patients, 25 hips). Patients undergoing PAO without prior hip arthroscopic surgery (PAOALONE group; 71 patients, 85 hips) were included as a comparison group. Demographic and radiological variables were recorded. Postoperative functional outcome scores (modified Harris Hip Score [mHHS], Hip Outcome Score [HOS], and International Hip Outcome Tool [iHOT-33]) were recorded at 6 months and annually postoperatively. Results: There were no demographic differences between the 2 groups at baseline. Acetabular version, femoral version, Tönnis grade, preoperative lateral center edge angle, and intraoperative procedures were not different between the 2 groups. At 1-year follow-up from the last hip surgical procedure, the mean (±SD) mHHS (73 ± 14 vs 86 ± 14, respectively; P < .001), HOS–Activities of Daily Living (84 ± 12 vs 93 ± 11, respectively; P = .007), HOS-Sport (62 ± 25 vs 85 ± 18, respectively; P < .001), and iHOT-33 (62 ± 21 vs 79 ± 20, respectively; P = .004) were decreased in the PREVSCOPE group versus the PAOALONE group. At last follow-up (mean, 18 months from the last hip surgical procedure), the mHHS and HOS-Sport were lower in the PREVSCOPE group versus the PAOALONE group. There was no difference in complication or reoperation rates between the 2 groups. Conclusion: Failed hip arthroscopic surgery before PAO for symptomatic hip dysplasia is associated with lower hip-specific functional outcomes within the first 1 year of follow-up despite similar baseline demographic and radiological characteristics. These differences persisted in certain outcome scores (mHHS, HOS-Sport) at last follow-up but were less pronounced than at 1 year.
Effects of reducing dietary methionine, linoleic acid, choline and increasing energy on performance and eggshell quality in aged laying hens.

An experiment was conducted to determine whether egg quality during the late stage of egg production can be improved by using diets that are effective in reducing egg size. The experiment was conducted in completely randomized design with six treatment groups and four replicates each with ten hens from 94 to 106 wk of age. Three 28-d periods used for different dietary factors including: 1) Control (C); 2) Control with low (0.24%) methionine (LM); 3) Control with low (0.42%) linoleic acid (LLA); 4) Control with high (3000Kcal/kg) energy (HE); 5) Control with low (0.2, 0.42%, no supplement) methionine, linoleic acid, choline and high energy (3000Kcal/kg) (LMLLA-LCH-HE) and 6) Control with low (no supplement) choline (LCH). The data were analyzed using the General Linear Model procedure of SAS software (1992). Overall feed intake was significantly (P<0.05) lower for the hens fed HE diets compared to the control. Overall egg weight and albumin weight was significantly (P<0.05) lower for the hens fed LM and LM-LLA-LCH-HE compared to the control. Overall egg mass, egg production and eggshell thickness was not affected by treatments. The results indicate that certain manipulations of methionine, choline, linoleic acid, energy or the combination of these nutrients have the potential to reduce egg weight without affecting egg mass, egg production and eggshell thickness during the latter stage of the egg production cycle.
Development of Poly(propylene) Surface Topography During Corona Treatment

Atomic force microscopy (AFM), contact-angle measurements, and X-ray photoelectron spectroscopy (XPS or ESCA) were used to characterize biaxially oriented poly(propylene) (PP) films modified by exposure to a corona discharge. Surface analysis was performed on PP films modified at various corona energies to explore the changes in surface topography, wettability, and oxidation state resulting from the corona treatment. Even at low corona energies, water-soluble low-molecular-weight oxidized materials (LMWOM) are formed. These LMWOM products agglomerate into small topographical mounds that are visible in the AFM images. For the detection of LMWOM on corona-treated surfaces, AFM appears to be at least as sensitive as contact-angle measurements or ESCA. A major advantage of AFM relative to the other surface analytical techniques used to confirm the presence of the LMWOM is that no washing of the surface with water is required in conjunction with the AFM analysis.