Miracle-dz/UniFAR-FTUs huggingface dataset:
Mate guarding in the Seychelles warbler is energetically costly and adjusted to paternity risk

Males may increase their fitness through extra–pair copulations (copulations outside the pair bond) that result in extra–pair fertilizations, but also risk lost paternity when they leave their own mate unguarded. The fitness costs of cuckoldry for Seychelles warblers (Acrocephalus sechellensis) are considerable because warblers have a single–egg clutch and, given the short breeding season, no time for a successful replacement clutch. Neighbouring males are the primary threat to a male's genetic paternity. Males minimize their loss of paternity by guarding their mates to prevent them from having extra–pair copulations during their fertile period. Here, I provide experimental evidence that mate–guarding behaviour is energetically costly and that the expression of this trade–off is adjusted to paternity risk (local male density). Free–living males that were induced to reduce mate guarding spent significantly more time foraging and gained significantly better body condition than control males. The larger the reduction in mate guarding, the more pronounced was the increase in foraging and body condition (accounting for food availability). An experimental increase in paternity risk resulted in an increase in mate–guarding intensity and a decrease in foraging and body condition, and vice versa. This is examined using both cross–sectional and longitudinal data. This study on the Seychelles warbler offers experimental evidence that mate guarding is energetically costly and adjusted to paternity risk.
Isobaric Tags for Relative and Absolute Quantitation (iTRAQ)-Based Comparative Proteome Analysis of the Response of Ramie under Drought Stress

In this study, we conducted the first isobaric tags for relative and absolute quantitation (isobaric tags for relative and absolute quantitation (iTRAQ))-based comparative proteomic analysis of ramie plantlets after 0 (minor drought stress), 24 (moderate drought stress), and 72 h (severe drought stress) of treatment with 15% (w/v) poly (ethylene glycol)6000 (PEG6000) to simulate drought stress. In our study, the association analysis of proteins and transcript expression revealed 1244 and 968 associated proteins identified in leaves and roots, respectively. L1, L2, and L3 are leaf samples which were harvested at 0, 24, and 72 h after being treated with 15% PEG6000, respectively. Among those treatment groups, a total of 118, 216, and 433 unique proteins were identified as differentially expressed during L1 vs. L2, L2 vs. L3, and L1 vs. L3, respectively. R1, R2, and R3 are root samples which were harvested at 0, 24, and 72 h after being treated with 15% PEG6000, respectively. Among those treatment groups，a total of 124, 27, and 240 unique proteins were identified as differentially expressed during R1 vs. R2, R2 vs. R3, and R1 vs. R3, respectively. Bioinformatics analysis indicated that glycolysis/gluconeogenesis was significantly upregulated in roots in response to drought stress. This enhancement may result in more glycolytically generated adenosine triphosphate (ATP) in roots to adapt to adverse environmental conditions. To obtain complementary information related to iTRAQ data, the mRNA levels of 12 proteins related to glycolysis/gluconeogenesis in leaves and 7 in roots were further analyzed by qPCR. Most of their expression levels were higher in R3 than R1 and R2, suggesting that these compounds may promote drought tolerance by modulating the production of available energy.
Position statement Ankyloglossia and breastfeeding

Ankyloglossia (‘tongue-tie’) is a relatively common congenital anomaly characterized by an abnormally short lingual frenulum, which may restrict tongue tip mobility. There is considerable controversy regarding its diagnosis, clinical significance and management, and there is wide variation in practice in this regard. Most infants with ankyloglossia are asymptomatic and do not exhibit feeding problems. Based on available evidence, frenotomy cannot be recommended for all infants with ankyloglossia. There may be an association between ankyloglossia and significant breastfeeding difficulties in some infants. This subset of infants may benefit from frenotomy (the surgical division of the lingual frenulum). When an association between significant tongue-tie and major breastfeeding problems is clearly identified and surgical intervention is deemed to be necessary, frenotomy should be performed by a clinician experienced with the procedure and using appropriate analgesia. More definitive recommendations regarding the management of tongue-tie in infants await clear diagnostic criteria and appropriately designed trials.
Reinforcement learning in the presence of rare events

We consider the task of reinforcement learning in an environment in which rare significant events occur independently of the actions selected by the controlling agent. If these events are sampled according to their natural probability of occurring, convergence of conventional reinforcement learning algorithms is likely to be slow, and the learning algorithms may exhibit high variance. In this work, we assume that we have access to a simulator, in which the rare event probabilities can be artificially altered. Then, importance sampling can be used to learn with this simulation data. We introduce algorithms for policy evaluation, using both tabular and function approximation representations of the value function. We prove that in both cases, the reinforcement learning algorithms converge. In the tabular case, we also analyze the bias and variance of our approach compared to TD-learning. We evaluate empirically the performance of the algorithm on random Markov Decision Processes, as well as on a large network planning task.
Fast procedure for constructing an accurate dynamic average-value model of synchronous machine-rectifier systems

The analytical derivation of the average-value models (AVMs) for synchronous-machine-fed rectifier systems depends on many factors and is challenging in general. Various models presented in the literature rely on a single operating mode and a dc filter configuration. A recently proposed parametric approach utilizes a detailed simulation as a basis to establish an AVM that uses a proper full-order qd generator model. This paper presents a procedure to extract the appropriate nonlinear algebraic functions to represent the rectifier averaged behavior. In contrast to existing methods, the proposed procedure does not require significant analytical derivations and/or computational resources and results in a highly accurate dynamic AVM. The proposed methodology is validated with the results of detailed simulation and hardware experiment, and is shown to be very accurate in predicting the large-signal time-domain transients as well as the small-signal frequency-domain characteristics.
Transduction of an HLA-DP4–restricted NY-ESO-1–specific TCR into Primary Human CD4+ Lymphocytes

cDNAs encoding functional T cell receptor (TCR) α and β chains from a CD4+ T cell line (SG6) generated by repeated stimulation of a melanoma patient's peripheral blood mononuclear cells with HLA-DP4–restricted, NY-ESO-1–specific peptide p161-180 were cloned using a 5′rapid amplification of cDNA end method. Three different TCR α chains and 7 TCR β chains were found among the 84 α and 162 β cDNA clones tested. By screening different combination of the α/β chains using RNA electroporation, TRAV9-1 (Vα22.1) and TRBV20-1 (Vβ2) were found to be the functional pair in line SG6. Antibody blocking experiments confirmed that the specificity of TRAV9-1/TRBV20-1 mRNA-transfected T cells were CD4 dependent and HLA-DP4 restricted. A retroviral vector expressing both TRAV9-1 and TRBV20-1 was constructed and used for transduction of OKT3-stimulated peripheral blood lymphocytes from melanoma patients. TCR-transduced CD4 T cells were capable of recognizing peptide-pulsed antigen-presenting cells (Epstein-Barr virus transformed B-cells, dendritic cells, and peripheral blood mononuclear cells), and protein-pulsed dendritic cells. Transduced cells were also capable of proliferation upon peptide stimulation and recognized peptide concentrations that were recognized by the parental line (0.2 μM). In contrast to SG6, which could not recognize human tumors, TCR-transduced CD4 T cells could specifically recognize NY-ESO-1/HLA-DP4–expressing melanoma cells. Major histocompatibility complex class II TCR-transduced CD4 T cells provides an alternative source of tumor antigen-specific T cells for adoptive immunotherapy of cancer patients.
Size Matters - 'Over'investments in a Relational Contracting Setting

The corporate finance literature documents that managers tend to overinvest into physical assets. A number of theoretical contributions have aimed to explain this stylized fact, most of them focussing on a fundamental agency problem between shareholders and managers. The present paper shows that overinvestments are not necessarily the (negative) consequence of agency problems between shareholders and managers, but instead might be a second-best optimal response if the scope of court-enforceable contracts is limited. In such an environment a firm has to rely on relational contracts in order to manage the agency relationship with its workforce. The paper shows that investments into physical productive assets enhance the enforceability of relational contracts and hence investments optimally are “too high”.
Toxicity of metabolites produced by the "Alternaria".

The presence of toxin-producing fungi in foodstuffs and other agricultural commodities is well established (1-3). The Alternaria, Aspergilli, Fusaria and Penicillia have been repeatedly implicated as the principal coinhabitants of products in which toxicity has been demonstrated (4,5). Numerous compounds have been isolated that can explain the toxicity of the Aspergilli, Fusaria, and Penicillia. Among the more important of these are the aflatoxins, patulin, penicillic acid, and sterigmatocystin, because of their carcinogenic potential; the ochratoxins, citrinin, cyclopiazonic acid, and the estrogenic zearalenone because of a variety of high toxicities and their frequent appearance in moldy foodstuffs. By comparison, toxic components of the Alternaria have been studied to only a small extent. The Alternaria are found on wheat, barley, oats, sorghum, corn, and peanuts (4,6,7). Animal feeds and silage that contain these crops, as well as alfalfa and grass hay are also good sources (4). The Alternaria are plant pathogens and thus can contaminate food through field infection as well as through storage. Black spot of Japanese pear, brown
Double-Switch Single-Transformer Cell Voltage Equalizer Using a Half-Bridge Inverter and a Voltage Multiplier for Series-Connected Supercapacitors

Cell voltage equalizers are necessary to ensure years of operation for series-connected supercapacitors (SCs) by eliminating cell voltage imbalance. Conventional equalizers require numerous switches and/or magnetic components; hence, the circuit complexity and size tend to increase. In this paper, a double-switch single-transformer equalizer, which is based on the combination of a half-bridge inverter and a voltage multiplier, is proposed. The operation of the proposed equalizer is analyzed in detail, and a dc equivalent circuit is mathematically derived. Experimental equalization tests were performed for eight SCs connected in series under a voltage-imbalanced condition. The energy of the series-connected SCs was preferentially redistributed to SCs with low voltages, and eventually, the voltage imbalance was eliminated, demonstrating the equalization performance. Simulation-based equalizations using the derived dc equivalent circuit were also performed under the same condition as the experiments. The experimental and simulation results were in good agreement, indicating that the derived dc equivalent circuit can adequately express real equalization profiles.
Detection in the stochastic block model with multiple clusters: proof of the achievability conjectures, acyclic BP, and the information-computation gap

In a paper that initiated the modern study of the stochastic block model, Decelle et al., backed by Mossel et al., made the following conjecture: Denote by $k$ the number of balanced communities, $a/n$ the probability of connecting inside communities and $b/n$ across, and set $\mathrm{SNR}=(a-b)^2/(k(a+(k-1)b)$; for any $k \geq 2$, it is possible to detect communities efficiently whenever $\mathrm{SNR}>1$ (the KS threshold), whereas for $k\geq 4$, it is possible to detect communities information-theoretically for some $\mathrm{SNR}<1$. Massouli\'e, Mossel et al.\ and Bordenave et al.\ succeeded in proving that the KS threshold is efficiently achievable for $k=2$, while Mossel et al.\ proved that it cannot be crossed information-theoretically for $k=2$. The above conjecture remained open for $k \geq 3$. This paper proves this conjecture, further extending the efficient detection to non-symmetrical SBMs with a generalized notion of detection and KS threshold. For the efficient part, a linearized acyclic belief propagation (ABP) algorithm is developed and proved to detect communities for any $k$ down to the KS threshold in time $O(n \log n)$. Achieving this requires showing optimality of ABP in the presence of cycles, a challenge for message passing algorithms. The paper further connects ABP to a power iteration method with a nonbacktracking operator of generalized order, formalizing the interplay between message passing and spectral methods. For the information-theoretic (IT) part, a non-efficient algorithm sampling a typical clustering is shown to break down the KS threshold at $k=4$. The emerging gap is shown to be large in some cases; if $a=0$, the KS threshold reads $b \gtrsim k^2$ whereas the IT bound reads $b \gtrsim k \ln(k)$, making the SBM a good study-case for information-computation gaps.
Hype or Help? A Longitudinal Field Study of Virtual World Use for Team Collaboration

Despite increasing organizational interest and investment in virtual worlds (VWs), there is a lack of research on the benefits of VWs. When and how does the use of VW systems engender better organizational outcomes than traditional collaborative technologies? This paper investigates the value of VWs for team collaboration. Team collaboration is particularly relevant in studying VWs given the rich interactive nature of VWs and an increasing organizational reliance on virtual teamwork. To understand the value of VW use for team collaboration, we examine the relationship between a team’s disposition toward IT, their general disposition (personality) and VW use in influencing team cohesion and performance. We conducted a field study that compares two collaborative technology systems – one that is based on a traditional desktop metaphor and one that is grounded in the principles of a virtual world. We tracked the use of the systems for one year. We analyzed data at the team level and the results generally support our model, with agreeableness, conscientiousness, extraversion, openness, and computer self-efficacy interacting with time and technology type to positively influence team technology use. We also found that the use of the virtual world system positively influenced the relationship between technology use and team cohesion, which, in turn, predicts team performance. The model explains 57 percent, 21 percent, and 24 percent of the variance in team technology use, team cohesion, and team performance, respectively. IT,
Continuous venovenous hemofiltration with citrate-based replacement fluid: efficacy, safety, and impact on nutrition.

BACKGROUND Citrate-based continuous venovenous hemofiltration (CVVH) replacement fluids provide effective and simple regional anticoagulation. However, concern over toxicity has limited citrate use, especially at the high filtration rates advocated for better outcomes. We used volumes of 72 L/d in patients at high risk for bleeding and investigated the treatment's efficacy, safety, and clinical results, especially with regard to nutrition supplementation. METHODS A standard replacement solution (trisodium citrate, 13.3 mmol/L) was infused at up to 3 L/h in predilution CVVH, and ultrafiltration was increased further for net fluid removal. Calcium was repleted centrally. We retrospectively evaluated metabolic control, citrate toxicity, circuit patency, hemorrhagic complications, hemodynamics, vasopressor use, nutrition, renal recovery, and mortality. RESULTS Seventy-six patients with 766 CVVH patient-days were analyzed. Mean replacement fluid rate was 31 mL/kg/h (35 mmol/h of citrate), with hemofiltration of 35 mL/kg/h (67 +/- 11 L/d). No significant bleeding, citrate toxicity, or hypocalcemia was observed, and 74% required additional alkali therapy. Dialyzer patency was 58% at 48 hours. Control of fluid, electrolytes, and azotemia was excellent (serum creatinine level, 1.7 mg/dL [150 micromol/L]; blood urea nitrogen, 42 mg/dL [15 mmol/L]). Fluid removal permitted protein (1.7 g/kg/d) and calorie (30 kcal/kg/d) nutrition in high fluid volumes. Vasopressor use and central pressures decreased significantly. Cumulative 28-day intensive care unit survival was 58%, and 41% of these patients had renal recovery in the intensive care unit. Thirty percent of the entire cohort survived the hospitalization, and 53% of these patients recovered renal function. CONCLUSION CVVH with 3 L/h of citrate-based replacement fluid is a safe, efficient, and simple technique in patients at high risk for bleeding. It allows superb control of uremia and fluid balance and thereby permits aggressive nutritional support.
Pilot Study of Association of Bacteria on Breast Implants with Capsular Contracture

ABSTRACT Capsular contracture is the most common and frustrating complication in women who have undergone breast implantation. Its cause and, accordingly, treatment and prevention remain to be elucidated fully. The aim of this prospective observational pilot study was to test the hypothesis that the presence of bacteria on breast implants is associated with capsular contracture. We prospectively studied consecutive patients who underwent breast implant removal for reasons other than overt infection at the Mayo Clinic from February through September 2008. Removed breast implants were processed using a vortexing/sonication procedure and then subjected to semiquantitative culture. Twenty-seven of the 45 implants collected were removed due to significant capsular contracture, among which 9 (33%) had ≥20 CFU bacteria/10 ml sonicate fluid; 18 were removed for reasons other than significant capsular contracture, among which 1 (5%) had ≥20 CFU/10 ml sonicate fluid (P = 0.034). Propionibacterium species, coagulase-negative staphylococci, and Corynebacterium species were the microorganisms isolated. The results of this study demonstrate that there is a significant association between capsular contracture and the presence of bacteria on the implant. The role of these bacteria in the pathogenesis of capsular contracture deserves further study.
Evaluation of the aetiological spectrum of obstructive jaundice.

BACKGROUND Jaundice is a common problem in medical and surgical gastroenterological practice. The surgical jaundice can be caused by the obstruction of the bile duct as with gall stones, strictures, malignancy, such as cholangiocarcinoma (in which the jaundice is persistent and progressive), periampullary carcinoma, carcinoma gall bladder and carcinoma head of pancreas. The objective of this descriptive study was to evaluate the Etiological spectrum of obstructive jaundice. METHODS A prospective, descriptive study was carried out at Surgical Unit-II Holy family Hospital, Rawalpindi, from mid of May 2006 till March 2007. Sixty patients, who presented in the surgical OPD of Holy family Hospital, were included in the study. Thorough history and physical examination was followed by biochemical tests and various investigations like USG abdomen, ERCP, CT-Scan, & MRCP and histopathology. The data was analyzed using SPSS ver 14.0. RESULTS Of the 60 patients; 40 (66.66%) were male and 20 (33.33%) were female, their mean age being 49.50 years. Malignant obstructive jaundice was seen in 34 (56.66%) patients while 26 (43.33%) had benign etiology. Amongst the commonest symptom; clay coloured stools (75%) was more frequent in patients with malignant disease whereas abdominal pain (51.66%) was most common in benign conditions. Commonest malignancy was Carcinoma (Ca) of the head of pancreas 18/60 (30%) followed by Ca gall bladder 8/60 (13.33%), cholangiocarcinoma 7/60 (11.66%), and periampullary carcinoma 1/60 (1.66%). Choledocholithiasis 21/60 (35%) was the commonest benign cause followed by stricture of common bile duct 3/60 (5%) and acute pancreatitis 2/60 (3.33%). CONCLUSION Obstructive jaundice is common amongst females and the cause is mostly malignant. Ca head of pancreas is the commonest malignancy while Choledocholithiasis is the commonest benign cause. USG, ERCP and CT-Scan are important diagnostic modalities for evaluation of patient with obstructive jaundice with ERCP having the additional advantage of being therapeutic as well.
Performance of two-way amplify-and-forward relay networks over asymmetric channels

This paper considers a two-way amplify-and-forward (AF) relay network, where two users communicate with each other through an intermediate relay over asymmetric Nakagami-m channels. The average bit-error rate (BER) performance is analyzed for the relay under average power scaling (APS) and instantaneous power scaling (IPS) constraints. We demonstrate that this network operating in two time slots not only improves spectrum efficiency, but also achieves the same BER performance as that working in four time slots under the same total and individual power constraints. Both analytical and simulation results show that a user will have a lower error probability of detecting the other user's signals if this user has a worse channel condition with the relay. In addition, IPS achieves better performance than APS but costs higher computing load for the relay.
Treatment of neurolept-induced tardive dyskinesia

Tardive dyskinesia (TDK) includes orobuccolingual movements and “piano-playing” movements of the limbs. It is a movement disorder of delayed onset that can occur in the setting of neuroleptic treatment as well as in other diseases and following treatment with other drugs. The specific pathophysiology resulting in TDK is still not completely understood but possible mechanisms include postsynaptic dopamine receptor hypersensitivity, abnormalities of striatal gamma-aminobutyric acid (GABA) neurons, and degeneration of striatal cholinergic interneurons. More recently, the theory of synaptic plasticity has been proposed. Considering these proposed mechanisms of disease, therapeutic interventions have attempted to manipulate dopamine, GABA, acetylcholine, norepinephrine and serotonin pathways and receptors. The data for the effectiveness of each class of drugs and the side effects were considered in turn.