Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimality of the recursive data exchange protocol

Multiple parties observe correlated data generated independently and identically (in time) from a known joint distribution. Parties communicate with each other interactively to enable each party to recover the data observed by all the other parties and attain omniscience. We characterize the asymptotic growth of the number of bits of interactive communication required by the parties to attain omniscience up to the second-order term. For the converse, we provide a single-shot lower bound for the required number of bits of communication, which yields the asymptotic result as a special case. It is shown that the knowledge of the distribution can be used to modify the recently proposed recursive data exchange protocol to render it optimal up to the second-order term. As a corollary, we provide a precise characterization of the reduction in communication for omniscience due to interaction.
A receiver for LTE Rel-11 and beyond supporting non-contiguous carrier aggregation

Carrier aggregation (CA) is introduced in 3GPP LTE Rel-10 [1] to meet the demand for further increased bitrates. While LTE Rel-10 supports simultaneous reception of two carriers either in contiguous intra-band or in inter-band CA configuration, the upcoming LTE Rel-11 will add support for non-contiguous (NC) carriers within bands. Supporting NC CA in handsets is a demanding challenge for several reasons. Foremost, the total bandwidth spanned by the carriers may be several times the bandwidth of the individual carriers, possibly spanning an entire band with interfering signals between desired carriers. Furthermore, the distance between TX and RX carriers will vary and worse, may be much smaller than the fixed duplex distance for LTE Rel-8 and W-CDMA single carrier operation [2-5].
Neural Mechanisms Underlying the Cost of Task Switching: An ERP Study

Background When switching from one task to a new one, reaction times are prolonged. This phenomenon is called switch cost (SC). Researchers have recently used several kinds of task-switching paradigms to uncover neural mechanisms underlying the SC. Task-set reconfiguration and passive dissipation of a previously relevant task-set have been reported to contribute to the cost of task switching. Methodology/Principal Findings An unpredictable cued task-switching paradigm was used, during which subjects were instructed to switch between a color and an orientation discrimination task. Electroencephalography (EEG) and behavioral measures were recorded in 14 subjects. Response-stimulus interval (RSI) and cue-stimulus interval (CSI) were manipulated with short and long intervals, respectively. Switch trials delayed reaction times (RTs) and increased error rates compared with repeat trials. The SC of RTs was smaller in the long CSI condition. For cue-locked waveforms, switch trials generated a larger parietal positive event-related potential (ERP), and a larger slow parietal positivity compared with repeat trials in the short and long CSI condition. Neural SC of cue-related ERP positivity was smaller in the long RSI condition. For stimulus-locked waveforms, a larger switch-related central negative ERP component was observed, and the neural SC of the ERP negativity was smaller in the long CSI. Results of standardized low resolution electromagnetic tomography (sLORETA) for both ERP positivity and negativity showed that switch trials evoked larger activation than repeat trials in dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex (PPC). Conclusions/Significance The results provide evidence that both RSI and CSI modulate the neural activities in the process of task-switching, but that these have a differential role during task-set reconfiguration and passive dissipation of a previously relevant task-set.
Interferon-gamma release assays improve the diagnosis of tuberculosis and nontuberculous mycobacterial disease in children in a country with a low incidence of tuberculosis.

BACKGROUND Diagnosis of childhood tuberculosis (TB) is challenging. The widely used tuberculin skin test (TST) may produce -positive results because of cross-reactivity with nontuberculous mycobacteria or bacille Calmette-Guerin vaccination, resulting in unnecessary treatment. Two recently developed interferon- gamma release assays (IGRAs) show good diagnostic accuracy for active TB in adults; pediatric data are limited, particularly in areas with a low incidence of TB. We assessed the diagnostic accuracy of IGRAs for TB in children in an area with a low incidence of TB. METHODS In a hospital-based study, the diagnostic accuracy of the TST and 2 IGRAs (T SPOT-TB [T-SPOT; Oxford Immunotec] and QuantiFERON-TB Gold In-Tube [QFT-IT; Cellestis]) were assessed in a cohort of 73 children (median age, 39 months); 28 children with bacteriologically confirmed TB were compared with children without TB (23 with bacteriologically confirmed nontuberculous mycobacterial lymphadenitis and 22 with other nonmycobacterial respiratory tract infections). RESULTS The specificity for TB of QFT-IT was 100% (95% confidence interval [CI], 91%-100%), and the specificity of T-SPOT was 98% (95% CI, 87%-100%), both of which were considerably higher than the specificity of TST (58%; 95% CI, 42%-73%). The specificity of the TST was 10.5% (95% CI, 1%-33%) in children with nontuberculous mycobacterial lymphadenitis and was 100% (95% CI, 83%-100%) in children with other nonmycobacterial respiratory tract infections. The sensitivity of both QFT-IT and T-SPOT was 93% (95% CI, 77%-99%), and the sensitivity of the TST was 100% (95% CI, 88%-100%). Agreement between the IGRAs was 95.6% ( kappa =0.91); 6.8% of the IGRAs showed indeterminate results. CONCLUSIONS Both IGRAs showed high diagnostic value in bacteriologically confirmed childhood TB. Their advantage in this study, when performed in addition to the TST, was the ability to distinguish -positive TST results caused by nontuberculous mycobacterial disease, thereby reducing overdiagnosis of TB and guiding clinical management.
A spectral estimation technique to improve the efficiency of FDTD method for narrow-band microwave circuits

With the advances in computer technology, the finite-difference time-domain (FDTD) method is becoming increasingly popular in the analysis of microwave circuits. A major drawback of the conventional Yee FDTD implementation is the enormous time and memory required to characterize the resonant behavior of narrow-band circuits. In this paper, we introduce a technique which effectively employs a combination of Prony's extrapolation and adaptive sampling of the temporal data to reduce the number of FDTD iterations for resonant circuits. The new technique is applied to the characterization of a multilayered coplanar waveguide filter element. <<ETX>>
Repeat treatment of rheumatoid arthritis patients with a murine anti-intercellular adhesion molecule 1 monoclonal antibody.

OBJECTIVE To assess the safety and efficacy of a second course of treatment with a murine monoclonal antibody (MAb) to intercellular adhesion molecule 1 (ICAM-1; CD54) in active rheumatoid arthritis (RA). METHODS In an open-label study, 8 patients who had previously received a course of anti-ICAM-1 MAb received a second course. RESULTS The second course of therapy was associated with adverse effects suggestive of immune complex formation. Such adverse effects were not seen during the initial course of therapy. Clinical efficacy associated with the second course of therapy was less than that observed in the first course. CONCLUSION Repeated courses of therapy with a murine MAb to ICAM-1 would probably not be a useful therapeutic strategy in patients with RA, probably because of its immunogenicity.
Trends in Firewall Configuration Errors: Measuring the Holes in Swiss Cheese

The first quantitative evaluation of the quality of corporate firewall configurations appeared in 2004, based on Check Point Firewall-1 rule sets. In general, that survey indicated that corporate firewalls often enforced poorly written rule sets. This article revisits the first survey. In addition to being larger, the current study includes configurations from two major vendors. It also introduces a firewall complexity. The study's findings validate the 2004 study's main observations: firewalls are (still) poorly configured, and a rule -set's complexity is (still) positively correlated with the number of detected configuration errors. However, unlike the 2004 study, the current study doesn't suggest that later software versions have fewer errors.
Historical Evolution of Second-Line Therapy in Non-Small Cell Lung Cancer

Innovative therapeutic agents have significantly improved outcome with an acceptable safety profile in a substantial proportion of non-small cell lung cancer (NSCLC) patients, who depend on oncogenic molecular alterations for their malignant phenotype. Despite the survival improvement achieved with first-line chemotherapy, about 30% of patients do not obtain a tumor response. Moreover, those patients, initially sensitive to treatment, acquire resistance and develop tumor progression after a median of about 5 months. Approximately 60% of the patients progressing from first-line chemotherapy receive further systemic treatment in the second-line setting. Moreover, new options have emerged in the second-line armamentarium for the treatment of patients with NSCLC, including immune checkpoint inhibitors and antiangiogenic agents. The current review provides an overview on the clinical studies that gained the approval of chemotherapy agents (docetaxel and pemetrexed) and epidermal growth factor receptor gene–tyrosine kinase inhibitors as second-line treatment options for NSCLC patients, not carrying molecular alterations.
Identification key of the Rissooidea (Mollusca: Gastropoda) from Bulgaria with a description of six new species and one new genus

New investigations of freshwater habitats in mountainous regions and caves revealed six new species of the Rissooidea in Bulgaria. The new species are described here and photos of the holotypes are provided. In addition we added photos of the type localities. An identification key of the genera of the Rissooidea of Bulgaria gives an overview of the diversity of this group. The following species are described as new: Strandzhia bythinellopenia sp. n. , gen. n. , Grossuana slavyanica n. sp. , G. derventica n. sp. , Radomaniola strandzhica n. sp. , Bythiospeum devetakium n. sp. , Bythinella rilaensis n. sp.
Early Response to Highly Active Antiretroviral Therapy in HIV-1-Infected Kenyan Children

Objectives:To describe the early response to World Health Organization (WHO)-recommended nonnucleoside reverse transcriptase inhibitor (NNRTI)-based first-line highly active antiretroviral therapy (HAART) in HIV-1-infected Kenyan children unexposed to nevirapine. Design:Observational prospective cohort. Methods:HIV-1 RNA level, CD4 lymphocyte count, weight for age z score, and height for age z score were measured before the initiation of HAART and every 3 to 6 months thereafter. Children received no nutritional supplements. Results:Sixty-seven HIV-1-infected children were followed for a median of 9 months between August 2004 and November 2005. Forty-seven (70%) used zidovudine, lamivudine (3TC), and an NNRTI (nevirapine or efavirenz), whereas 25% used stavudine (d4T), 3TC, and an NNRTI. Nevirapine was used as the NNRTI by 46 (69%) children, and individual antiretroviral drug formulations were used by 63 (94%), with only 4 (6%) using a fixed-dose combination of d4T, 3TC, and nevirapine (Triomune; Cipla, Mumbai, India). In 52 children, the median height for age z score and weight for age z score rose from −2.54 to −2.17 (P < 0.001) and from −2.30 to −1.67 (P = 0.001), respectively, after 6 months of HAART. Hospitalization rates were significantly reduced after 6 months of HAART (17% vs. 58%; P < 0.001). The median absolute CD4 count increased from 326 to 536 cells/μL (P < 0.001), the median CD4 lymphocyte percentage rose from 5.8% before treatment to 15.4% (P < 0.001), and the median viral load fell from 5.9 to 2.2 log10 copies/mL after 6 months of HAART (P < 0.001). Among 43 infants, 47% and 67% achieved viral suppression to less than 100 copies/mL and 400 copies/mL, respectively, after 6 months of HAART. Conclusion:Good early clinical and virologic response to NNRTI-based HAART was observed in HIV-1-infected Kenyan children with advanced HIV-1 disease.
Epidemiology of drug-resistant tuberculosis in Chongqing, China: A retrospective observational study from 2010 to 2017

China is one of the top 30 countries with high multidrug-resistant tuberculosis (MDR-TB) and rifampin-resistant tuberculosis (RR-TB) burden. Chongqing is a southwest city of China with a large rural population. A retrospective observational study has been performed based on routine tuberculosis (TB) surveillance data in Chongqing from 2010 to 2017. The MDR/RR-TB notification rate increased from 0.03 cases per 100,000 population in 2010 to 2.09 cases per 100,000 population in 2017. The extensively drug-resistant TB (XDR-TB) notification rate has increased to 0.09 cases per 100,000 population in 2017. There was a decreasing detection gap between the number of notified MDR/RR-TB cases and the estimate number of MDR/RR-TB cases among all notified TB cases. The treatment success rate of MDR/RR-TB was 50.66% in this period. The rate of MDR/RR-TB in new TB cases was 6.23%, and this rate in previously treated TB cases was 32.7%. Despite the progress achieved, the prevalence of MDR/RR-TB was still high facing challenges including detection gaps, the regional disparity, and the high risk for MDR/RR-TB in elderly people and farmers. Sustained government financing and policy support should be guaranteed in the future.
Influence of isoflavone intake and equol-producing intestinal flora on prostate cancer risk.

BACKGROUND The age-adjusted incidence rate of prostate cancer (PCa) has been reported to be lower among Asians than Western populations. A traditional Japanese meal, high in soybean products or isoflavones, may be associated with a decreased risk of PCa. Equol, which is converted from daidzein by human intestinal flora, is biologically more active than any other isoflavone aglycone. MATERIALS AND METHODS We reviewed not only recent epidemiological studies on association of isoflavones with PCa risk, but also recent research on human intestinal bacteria responsible for converting daidzein into equol. Studies were systematically searched from the database published within the last 5 years of from 2008-2012. RESULTS Five out of 6 articles showed significant association of isoflavones with a decreased risk of PCa, and two of them consistently showed that equol-producers carry a significantly reduced risk of PCa. Furthermore, 5 human intestinal bacteria that can convert daidzein into equol were identified in the last 5 years. CONCLUSIONS If equol can reduce risk of PCa, a possible strategy for reducing the risk of PCa may be to increase the proportion of equol-producers by changing the intestinal flora to carrying an equol-producing bacterium with dietary alteration or probiotic technology.
Stent Placement for Treating IVC Stenosis Following “Left at Right” Adult Liver Transplantation

We read with great interest the paper by Chan et al (1) reporting ‘‘left at right’’ adult liver transplantation (LAR-LT): the feasibility of heterotopic implantation of left liver (LL) graft. The authors reported that this newprocedure enables the anastomosis of portal vein, hepatic vein, hepatic artery and biliary duct to be performed smoothly without any tension. We applied this procedure for the consecutive three recipients using LL graft plus caudate lobe (CL). Actually, every anastomosiswas easy to perform; however, all of them needed to undergo stent placement for the stenosis of the inferior vena cava (IVC) cranial to the anastomosis of hepatic vein. Case: Sixty-four-year-old male underwent LAR-LT for hepatitis B with hepatocellular carcinoma (HCC). His graft recipient weight ratio (GRWR) was 0.74, and the model for end-stage liver disease (MELD) score was 11. On postoperative day (POD) 11, the ascetic fluid volume increased up to more than 2500 mL, and a Doppler ultrasound examination revealed flat waveforms and slightly low flow velocities in hepatic vein. A CT scan showed compression and stretch of the IVC by the regenerated grafted liver parenchyma (Figure 1A and B). The hepatic venograph showed no evidence of stenosis, but IVC stenosis was visualized cranial to the anastomosis of hepatic vein by venacavography and there was a pressure gradient of 13 mmHg (Figure 1C). A 30-mm-diameter, 5-cm-long Cook-Z stent
Existence and Regularity of the Solution of a Time Dependent Hartree-Fock Equation Coupled with a Classical Nuclear Dynamics

We study an Helium atom (composed of one nucleus and two electrons) submitted to a general time dependent electric field, modeled by the Hartree-Fock equation, whose solution is the wave function of the electrons, coupled with the classical Newtonian dynamics, for the position of the nucleus. We prove a result of existence and regularity for the Cauchy problem, where the main ingredients are a preliminary study of the regularity in a nonlinear Schrodinger equation with semi-group techniques and a Schauder fixed point theorem.
Remodeling of motor nerve terminals in demyelinating axons of periaxin‐null mice

Myelin formation around axons increases nerve conduction velocity and influences both the structure and function of the myelinated axon. In the peripheral nervous system, demyelinating forms of hereditary Charcot‐Marie‐Tooth (CMT) diseases cause reduced nerve conduction velocity initially and ultimately axonal degeneration. Several mouse models of CMT diseases have been generated, allowing the study of the consequences of disrupting Schwann cell function on peripheral nerve fibers. Nevertheless, the effect of demyelination at the level of the neuromuscular synapse has been largely overlooked. Here we show that in mice lacking functional Periaxin (Prx) genes, a model of a recessive type of CMT disease known as CMT4F, neuromuscular junctions (NMJs) develop profound morphological changes in the preterminal region of motor axons. These changes include extensive preterminal branches that originate in demyelinated regions of the nerve fiber and axonal swellings associated with residually‐myelinated regions of the fiber. Using intracellular recording from muscle fibers we detected asynchronous failure of action potential transmission at high but not low stimulation frequencies, a phenomenon consistent with branch point failure. Taken together, our morphological and electrophysiological findings suggest that preterminal branching due to segmental demyelination near the neuromuscular synapse in Periaxin KO mice may underlie some characteristics of disabilities, including coordination deficits, present in this mouse model of CMT disease. These results reveal the importance of studying how demyelinating diseases might influence NMJ function and contribute to clinical disability. © 2008 Wiley‐Liss, Inc.
Quantification of the High Level of Endogeneity and of Structural Regime Shifts in Commodity Markets

We propose a “reflexivity” index that quantifies the relative importance of short-term endogeneity for several commodity futures markets (corn, oil, soybean, sugar, and wheat) and a benchmark equity futures market (E-mini S&P 500), from mid-2000s to October 2012. Our reflexivity index is defined as the average ratio of the number of price moves that are due to endogenous interactions to the total number of all price changes, which also include exogenous events. It is obtained by calibrating the Hawkes self-excited conditional Poisson model on time series of price changes. The Hawkes model accounts simultaneously for the co-existence and interplay between the exogenous impact of news and the endogenous mechanism by which past price changes may influence future price changes. Our robustness tests show that our index provides a ‘pure’ measure of endogeneity that is independent of the rate of activity, order size, volume or volatility. We find an overall increase of the reflexivity index since the mid-2000s to October 2012, which implies that at least 60–70 percent of commodity price changes are now due to self-generated activities rather than novel information, compared to 20–30 percent earlier. While our reflexivity index is defined on short-time windows (10–30 min) and thus does not capture long-term memory, we discover striking coincidence between its dynamics and that of the price hikes and abrupt falls that developed since 2006 and culminated in early 2009.
Total parathyroidectomy in a large cohort of cases with hyperparathyroidism associated with multiple endocrine neoplasia type 1: experience from a single academic center

Most cases of sporadic primary hyperparathyroidism present disturbances in a single parathyroid gland and the surgery of choice is adenomectomy. Conversely, hyperparathyroidism associated with multiple endocrine neoplasia type 1 (hyperparathyroidism/multiple endocrine neoplasia type 1) is an asynchronic, asymmetrical multiglandular disease and it is surgically approached by either subtotal parathyroidectomy or total parathyroidectomy followed by parathyroid auto-implant to the forearm. In skilful hands, the efficacy of both approaches is similar and both should be complemented by prophylactic thymectomy. In a single academic center, 83 cases of hyperparathyroidism/multiple endocrine neoplasia type 1 were operated on from 1987 to 2010 and our first surgical choice was total parathyroidectomy followed by parathyroid auto-implant to the non-dominant forearm and, since 1997, associated transcervical thymectomy to prevent thymic carcinoid. Overall, 40% of patients were given calcium replacement (mean intake 1.6 g/day) during the first months after surgery, and this fell to 28% in patients with longer follow-up. These findings indicate that several months may be needed in order to achieve a proper secretion by the parathyroid auto-implant. Hyperparathyroidism recurrence was observed in up to 15% of cases several years after the initial surgery. Thus, long-term follow-up is recommended for such cases. We conclude that, despite a tendency to subtotal parathyroidectomy worldwide, total parathyroidectomy followed by parathyroid auto-implant is a valid surgical option to treat hyperparathyroidism/multiple endocrine neoplasia type 1. Larger comparative systematic studies are needed to define the best surgical approach to hyperparathyroidism/multiple endocrine neoplasia type 1.